NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Alzheimer’s disease (AD) is the result of cellular and network dysfunction at a variety of levels. A key cellular regulator of brain function, astrocytes, are involved in maintenance of synaptic function, neuroinflammation, and the regulation of blood flow to meet the demands of neuronal activity. Astrocytes are intimately connected to other astrocytes, neurons and the vasculature, and communicate through calcium signaling that can be observed through imaging in the brain of living mouse models of AD throughout their lifespan during the progression of AD pathology.

PI_NAMEs: BACSKAI, BRIAN J (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: abeta oligomer;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;Amyloidosis;APP-PS1;Astrocytes;awake;Blood - brain barrier anatomy;Blood capillaries;Blood flow;Blood Vessels;blood-brain barrier function;Brain;Calcium;Calcium Signaling;Cause of Death;Cells;Central Nervous System;Cerebrovascular Circulation;Chronic;Communication;Complex;Dementia;Deposition;Deterioration;Development;Disease;Etiology;Evolution;Excision;experimental study;functional decline;Functional disorder;Glutamates;Health;Health Benefit;Health protection;Homeostasis;Human;Hyperemia;Image;Imaging Device;Impaired cognition;improved;in vivo;in vivo calcium imaging;in vivo imaging;Individual;Induced Neurons;interstitial;life span;Maintenance;Mediating;Metabolic;Molecular;mouse model;multiphoton imaging;multiphoton microscopy;Mus;Nerve Degeneration;network dysfunction;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;neuroinflammation;Neurologic;Neuronal Dysfunction;Neurons;neurovascular;neurovascular coupling;neurovascular unit;new therapeutic target;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Osmosis;Pathogenesis;Pathologic;pharmacologic;Photic Stimulation;Play;Potassium;Preparation;prevent;Process;Regulation;Reporter;restoration;Role;Senile Plaques;Sleep;sleep health;Synapses;synaptic function;Synaptic Transmission;System;targeted treatment;Testing;Therapeutic;therapeutic target;tool;United States;Visual Cortex;Wakefulness;Waste Products

PROJECT_TITLE: Astrocytes as governing pathological drivers of neurovascular dysfunction in AD

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Digestive Diseases;Intellectual and Developmental Disabilities (IDD);Mental Health;Microbiome;Neurosciences;Pain Research;Pediatric

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PHR: Project Narrative: Autism spectrum disorders (ASD) are highly prevalent neurodevelopmental disorders (1 in 44 children) characterized by impairments in social communication and interactions, restricted/repetitive behaviors and abnormal responses to sensory stimuli. Chronic disturbances in gastrointestinal function are often observed in individuals with ASD and are thought to contribute to social impairments and anxiety, yet the underlying disruptions to gastrointestinal-neural circuits in ASD are not known. The goal of this proposal is to characterize the development and function of dorsal root ganglia sensory neurons that innervate the gastrointestinal tract in mouse models for ASD, with the ultimate goal of developing novel treatment strategies to alleviate symptoms associated with peripheral sensory neuron abnormalities and improve ASD phenotypes.

PI_NAMEs: OREFICE, LAUREN LYNN (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Afferent Neurons;Anatomy;Anxiety;anxiety-like behavior;associated symptom;autism spectrum disorder;autism symptoms;Axon;Biological Assay;Brain;Brain Stem;Cells;Central Nervous System;Child;Chronic;Colon;Colorectal;Conscious;Data;Development;developmental disease;DNA Sequence Alteration;dysbiosis;Electrophysiology (science);Environment;Environmental Risk Factor;Esthesia;Etiology;Exhibits;Functional disorder;gastrointestinal;gastrointestinal function;Gastrointestinal Motility;gastrointestinal system;Gastrointestinal tract structure;Gene Mutation;Genes;Genetic;Goals;gut dysbiosis;gut microbiome;Histology;Impairment;improved;In Vitro;in vivo;individuals with autism spectrum disorder;Lead;Lifestyle-related condition;Light;Limb structure;Link;Measures;mechanical force;Mechanics;Methyl-CpG-Binding Protein 2;microbial;microbiome alteration;Modality;model of autism spectrum disorder;motility disorder;mouse genetics;mouse model;Mus;neural circuit;Neurodevelopmental Disorder;Neuronal Dysfunction;Neurons;neurotransmission;Nodose Ganglion;novel;Pain;pain behavior;pain signal;Pathology;Pathway interactions;Patients;Peripheral;Permeability;Phenotype;Population;Prevalence;Process;Property;Rectum;reduce symptoms;Reflex action;repetitive behavior;Reporting;response;Role;Sensory;sensory stimulus;Severities;Signal Transduction;Site;Skin;social;social anxiety;Social Behavior;social communication;social deficits;Social Interaction;Spinal;Spinal Cord;Spinal Ganglia;Stereotyped Behavior;stereotypy;stressor;Stretching;Tactile;Testing;Touch sensation;treatment strategy;Unconscious State;Vagus nerve structure;Viscera;Visceral pain;Withdrawal;Work

PROJECT_TITLE: Development, Function, and Dysfunction of Gastrointestinal Tract-Innervating Dorsal Root Ganglia Neurons in Autism Spectrum Disorder

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Human cancers, including malignant gliomas, activate molecular processes that protect the ends of chromosomes, called telomeres, over the course of many cycles of cell division. We recently discovered that genetic mutations in the SMARCAL1 gene play a critical role in pathological telomere maintenance in a subset of adult glioblastoma patients. The proposed studies will define the mechanistic role of SMARCAL1 in glioblastoma telomere maintenance and will investigate novel strategies for glioblastoma therapy using cell- based and mouse models of brain tumors.

PI_NAMEs: WAITKUS, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Actins;Adult;Adult Glioblastoma;aggressive therapy;Architecture;Astrocytes;Astrocytoma;ATRX gene;Brain Neoplasms;cancer cell;Cancer cell line;cancer type;Cell Cycle;Cell Line;Cell Maintenance;Cell Proliferation;Cells;Cessation of life;Childhood Glioma;Chromatin;Chromosomes;Data;design;DNA;DNA biosynthesis;DNA Damage;DNA replication fork;DNA Sequence;DNA Sequence Alteration;Enzymes;Epigenetic Process;extrachromosomal DNA;Genes;Genetic Engineering;genetically modified cells;Glioblastoma;Glioma;glioma cell line;Growth;Hela Cells;helicase;Histones;homologous recombination;Human;knock-down;Lead;Length;loss of function;loss of function mutation;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;Modeling;Molecular;Molecular Chaperones;mouse model;mutant;Mutation;novel;novel strategies;Osteosarcoma;Pathologic;Pathway interactions;Patients;permissiveness;Phenotype;Play;Process;promoter;Proteins;Publishing;Recurrence;replication stress;Reverse Transcription;RNA;RNA Interference;Role;Sarcoma;Site;Stress;Structure;synthetic lethal interaction;Telomerase;telomere;Telomere Maintenance;Telomere Pathway;Testing;Therapeutic;therapeutic target;TP53 gene;Tumorigenicity;United States;virtual;Xenograft procedure

PROJECT_TITLE: The role of SMARCAL1 in glioma telomere maintenance.


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Neurosciences;Sarcopenia

ORG_CITY: WINSTON-SALEM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Denervation is strongly implicated in the onset and progressive decline of skeletal muscle mass, composition, and function, termed sarcopenia. By using optogenetics, sophisticated imaging techniques and gene expression analysis, this study will define the mechanisms by which impaired central autonomic network regulation of the peripheral SNS leads to skeletal muscle sympathetic and motor denervation and loss in mass and strength to inform a new approach to attenuate or reverse sarcopenia.

PI_NAMEs: DELBONO, OSVALDO  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acceleration;Adrenergic Receptor;Affect;Age;age related decline;Aging;Attenuated;Axon;Cell Nucleus;Chronic;Collection;Data;delivery vehicle;demethylation;Denervation;design;Development;disability;Disease;extracellular;Failure;G-Protein-Coupled Receptors;Gene Expression;Gene Expression Profiling;Gene Silencing;Genes;Halorhodopsins;Health;Hindlimb;Homeobox;human old age (65+);Imaging Techniques;Impairment;improved;innovation;Intervention;Label;light gated;Measures;Mediating;Methylation;Molecular;Molecular Target;Monitor;Motor;motor control;Motor Neurons;Mus;Muscle;Muscle Fibers;muscle form;Muscle function;Muscular Atrophy;muscular structure;nerve supply;Neurodegenerative Disorders;Neuromuscular Junction;Neurons;Neurotransmitters;Norepinephrine;novel strategies;old mice;older adult;optogenetics;Patch-Clamp Techniques;pathological aging;Peripheral;physiologic stressor;Physiological;Pontine structure;postsynaptic;presynaptic;protein expression;Proteins;Publishing;Quality of life;Reaction;Recombinant adeno-associated virus (rAAV);Regulation;remediation;retrograde transport;Role;sarcopenia;side effect;Signal Transduction;Skeletal Muscle;Spinal Cord;Sympathetic Nervous System;Sympathomimetics;Synaptic Vesicles;Testing;Time;Tissues;tool;Transcript;transcription factor;transcriptome sequencing;transmission process;TRPV1 gene;vector;vesicular release;voltage;Wasting Syndrome

PROJECT_TITLE: Role of Central Autonomic Relays in Aging Sarcopenia

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: DENTON

ORG_NAME: TEXAS WOMAN'S UNIVERSITY

ORG_STATE: TX

PHR: Black pregnant women are more likely to experience racial discrimination and depressive symptoms and have higher risk for vitamin D deficiency and preterm birth (< 37 completed weeks gestation) compared with White women. Identifying the genomic inflammatory pathways that relate racial discrimination, depressive symptoms and vitamin D deficiency with preterm birth may lead to early identification of risk for preterm birth for Black women, and development of interventions to reduce preterm birth disparities among these women.

PI_NAMEs: WOO, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: MARTIN, IMAN

PROJECT_TERMS: 37 weeks gestation;Acceleration;Alleles;Anti-Inflammatory Agents;Binding;Bioinformatics;Biological;Biological Assay;Birth;Black American;Black Populations;Black race;black women;Blood;Cell Nucleus;Cells;cohort;Competence;cytokine;Data;Dendritic Cells;depressive symptoms;differential expression;Dihydroxycholecalciferols;disparities in women;DNA;Early identification;effective intervention;experience;Foundations;Freezing;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;genome-wide;genomic signature;Genomics;Genotype;Gestational Age;Goals;high risk;IL8 gene;Immune;immune function;Immune system;Immunomodulators;immunoregulation;improved;Individual;Infant;Inflammation;Inflammatory;inflammatory marker;insight;Interferons;Interleukin-1 beta;Interleukin-10;Interleukin-4;Interleukin-6;K-Series Research Career Programs;Laboratories;Leadership;Learning;Link;liquid chromatography mass spectrometry;Lymphocyte;Maternal-Fetal Exchange;Measures;Mediating;Mentors;Mentorship;monocyte;Mononuclear;neonatal morbidity;Not Hispanic or Latino;Outcome;Parents;participant enrollment;Pathway interactions;Peripheral;Peripheral Blood Mononuclear Cell;Plasma;Postpartum Depression;Postpartum Women;predictive marker;Pregnancy;pregnant;Pregnant Women;Premature Birth;Psychosocial Factor;Questionnaires;racial discrimination;Research;Research Personnel;Risk;RNA;Role;Sampling;skills;Solid;Supervision;systemic inflammatory response;Term Birth;therapy development;Time;Tissue-Specific Gene Expression;TNF gene;Training;Training Support;transcription factor;Transcription Factor AP-1;Transcriptional Activation;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Variant;Vitamin D;Vitamin D Deficiency;Vitamin D-Binding Protein;Vitamin D3 Receptor;White Women;Woman

PROJECT_TITLE: Genomic signatures of inflammation: Pathways of racial discrimination, depressive symptoms, Vitamin D status with preterm birth among Black women


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Disability Research;Genetics;Heart Disease;Infant Mortality;Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: NARRATIVE This proposal creates the largest, best-characterized adult cohort of d-transposition of the great arteries to date in order to explore the structural and functional brain MRI features associated with adult executive function and the potential modulating effects of common genetic variants in neuroresilience and hypoxia genes. Successful completion of this study would be relevant to patients with many types of congenital heart diseases and increase our understanding of prenatal versus adaptive changes associated with altered executive function and may help identify potential pathways for protective versus modifying therapeutic interventions.

PI_NAMEs: GRANT, PATRICIA ELLEN (contact);GURVITZ, MICHELLE

PROGRAM_OFFICER_NAME: SCHWARTZ, BRYANNA NICOLE

PROJECT_TERMS: Address;Adult;Affect;Alleles;Apolipoprotein E;Birth;Boston;Brain;brain magnetic resonance imaging;Cardiac;Cardiovascular system;Caring;Child;Cognitive;cohort;Complex;congenital heart abnormality;d-transposition of the great arteries;Data;Development;Diffusion;disability;Equilibrium;Executive Dysfunction;executive function;Functional Magnetic Resonance Imaging;Future;Genes;genetic testing;genetic variant;Genotype;Goals;Hematocrit procedure;high risk;Hypoxia;Image Analysis;Impairment;improved;improved outcome;in utero;Independent Living;Individual;infancy;Intervention;Knowledge;late life;Life;Live Birth;Magnetic Resonance Imaging;Measures;Medical;Mental Health;Methods;multimodality;Neurocognitive;Neurodevelopmental Disability;Neuropsychology;novel;operation;Operative Surgical Procedures;Organizational Change;Outcome;Patients;Pattern;Peripheral;Phenotype;postnatal;prenatal;prenatal therapy;protective pathway;resilience;response;Rest;Risk;Role;Services;Testing;Therapeutic Intervention;Time;United States;Variant

PROJECT_TITLE: Exploring the relationship between advanced multimodal brain MRI phenotypes, genes and cognitive outcome in adults with CHD

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Data Science;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Radiation Oncology

ORG_CITY: SAN DIEGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: SAN DIEGO STATE UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Americans over age 65 are the largest group of patients and survivors of cancer in the U.S. and are also the most likely to experience sub-optimal treatment outcomes. Assessment of these factors, as part of a clinical exam, can help reduce risk. However, assessment and documentation of age-related risk is not well- coordinated, putting older adults at greater risk, especially diverse older patients such as those with limited English proficiency. The proposed project seeks to examine medical record and multi-level factors that can improve assessment of age-related risk and documentation with a broader goal of improving treatment planning and care for diverse older adults with cancer.

PI_NAMEs: SCHIAFFINO, MELODY K (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Address;Adult;Affect;age effect;age related;Aging;algorithm development;Algorithms;American;Award;Bioinformatics;Biometry;cancer care;Cancer Center;cancer health disparity;cancer risk;Cancer Survivor;cancer therapy;cancer type;care coordination;care delivery;care fragmentation;career;career development;Caring;Cities;Classification;Client satisfaction;Clinic;Clinical;Clinical assessments;clinical decision-making;clinical examination;clinical implementation;clinical practice;Clinical Trials;Communication;Comprehensive Cancer Center;Data;Data Science;Data Set;Decision Making;Dedications;demographics;design;Development;Diagnosis;Disease;Disparity;diverse data;Doctor of Philosophy;Documentation;Education;Elderly;Electronic Health Record;English Language;Ensure;Epidemiology;Equity;evidence base;experience;Face;Faculty;Future;Geriatric Assessment;Geriatrics;Gerontology;Goals;health disparity;health equity;Health Services Research;Health Status;Health system;human old age (65+);implementation science;improved;information gathering;Interview;K-Series Research Career Programs;Knowledge;Language;Limited English Proficiency;Location;Machine Learning;Malignant Neoplasms;medical examination;Medical Records;medical specialties;Medicine;member;Mentors;Methods;Minority;Natural Language Processing;older adult;older patient;Oncologist;Oncology;oncology program;Outcome;patient health information;patient-clinician communication;Patient-Focused Outcomes;Patients;Pattern;Persons;predictive modeling;Prevalence;Process;professor;Provider;Quality of Care;Radiation;Radiation Oncology;Research;Research Personnel;Risk;Risk Assessment;Risk Factors;Risk Reduction;routine practice;Scientist;screening;Series;shared decision making;skills;Specific qualifier value;Survivors;Symptom Burden;symptom treatment;System;tenure track;Testing;Time;tool;Training;Translational Research;Treatment outcome;treatment planning;Treatment-related toxicity;Uncertainty;Universities;unstructured clinical data;unstructured data;Variant

PROJECT_TITLE: Improving age-related risk assessment and documentation for diverse older adults with cancer

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MADISON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE  The development of novel, effective pharmaceutical compounds is a major public health concern in  light of the rise of antibiotic resistance, the resilience of many types of cancers, and other key health  issues. Addition of fluorine to biologically active molecules, such as drug candidates, can increase the  effectiveness of these molecules by increasing their potency, enabling them to be more easily  absorbed, and modulating how our bodies metabolize them. This research entails the invention of a  novel, mild method for the installment of fluorine to key building blocks and the study of the mechanism  of this chemistry.

PI_NAMEs: LACKER, CAITLIN REBECCA (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Copper as a Photocatalyst: Applications in Decarboxylative Fluorination


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Dry eye disease is a multifactorial disease of the ocular surface characterized by impaired tear film homeostasis accompanied by ocular symptoms that affects approximately 6.8% of adults in the USA, with a global prevalence as high as 50%. Despite this significant disease burden, there are currently just four FDA- approved therapies for dry eye disease, each targeting only the inflammatory pathway and having limited efficacy. The proposed research will advance novel dry eye disease therapeutics that promote tear fluid secretion by targeting ion transport proteins on epithelial cells lining the ocular surface.

PI_NAMEs: PASRICHA, NEEL DAVE (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: absorption;Adult;Affect;animal model development;Animals;Apical;Award;burden of illness;Calcium;career development;Caring;Carrier Proteins;Cauterize;Cell Culture Techniques;cell injury;Cell Line;Chloride Channels;Clinical Research;Clinical Trials;conjunctiva;Cornea;corneal epithelium;cost;Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;Data;drug candidate;drug development;drug discovery;drug efficacy;Dry Eye Syndromes;Duct (organ) structure;Educational workshop;electrical potential;Electrophysiology (science);Epithelial Cells;epithelial Na+ channel;Epithelium;experience;Experimental Animal Model;Experimental Models;Eye;Eye diseases;eye dryness;FDA approved;Film;Fluids and Secretions;Goals;high throughput screening;Homeostasis;Human;human data;human subject;Impairment;in vivo;in vivo evaluation;Inflammatory;inhibitor;Ion Transport;Ions;Knowledge;lacrimal;Learning;Liquid substance;mathematical model;Measurement;Measures;Membrane;Mentors;Methods;Modeling;mouse model;Mus;novel;novel diagnostics;novel therapeutic intervention;ocular surface;ocular surface disease;Ophthalmologist;Ophthalmology;Osmolar Concentration;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Phase II Clinical Trials;Phenolsulfonphthalein;Potassium Channel;Prevalence;programs;Research;Research Personnel;Residencies;Rewards;Role;Scientific Advances and Accomplishments;Signal Transduction;skills;small molecule;Societies;Stratified Epithelium;Surrogate Markers;Symptoms;targeted treatment;Testing;Therapeutic;tool development;Training;Translating;Translational Research;Triazines;Work

PROJECT_TITLE: Human Ocular Surface Electrophysiology


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DALLAS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Alterations in the balance of inhibitory and excitatory neurons are thought to underlie diverse neurological disorders including those involving spinal cord such as pain, itch, touch, and sense of limb position. PTF1A and its downstream target PRDM13 are essential regulators of this balance in multiple regions of the nervous system including spinal cord, cerebellum, and retina. Regulatory mechanisms identified here may influence strategies for manipulating the fate of stem cells for regenerative purposes, and are likely to provide fundamental principles of gene regulation common to developing systems.

PI_NAMEs: JOHNSON, JANE E (contact)

PROGRAM_OFFICER_NAME: KOSTER, MARANKE IRENE

PROJECT_TERMS: Address;Adult;Affect;Alleles;Appearance;ASCL1 gene;Behavior;Behavioral;BHLH Protein;Binding;Binding Sites;Biochemical;Biological Assay;Birth;cell type;Cells;Cerebellum;ChIP-seq;Chromatin;chromatin modification;Defect;Development;Disease;Dorsal;Ectopic Expression;Embryo;Engineering;Enhancers;Ensure;Enzymes;Epigenetic Process;Equilibrium;excitatory neuron;experimental study;Future;gain of function;Gene Expression Regulation;gene repression;Genes;Genetic;Genetic Transcription;Genomic Segment;Genomics;Germ Cells;Helix-Turn-Helix Motifs;histone modification;Human;Hypersensitivity;in vivo;inhibitory neuron;Knockout Mice;Limb structure;Link;loss of function;Methyltransferase;Modeling;Molecular;Mus;mutant;Mutant Strains Mice;Mutation;nerve stem cell;Nervous System;Nervous System Disorder;Neural tube;Neurodegenerative Disorders;neurodevelopment;Neurological Models;neuronal circuitry;Neurons;Nucleic Acid Regulatory Sequences;Pain;Phenotype;Population;Positioning Attribute;Process;progenitor;Proprioception;Pruritus;recruit;regenerative cell;Reporter;Repression;response;Retina;Site;somatosensory;Specific qualifier value;Spinal Cord;stem cell fate;stem cells;System;Testing;tissue regeneration;Touch sensation;Transcription Coactivator;transcription factor;Transcription Repressor;transcriptome sequencing

PROJECT_TITLE: Transcription Factor Control of Neuronal Diversity

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: ES

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: LEXINGTON

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Outcomes and results from the proposed activities and research of the UK-SRC will provide important technology tools and insights for primary stakeholders for improving Superfund site risk assessment and management, specifically related to the class of compounds known as halogenated organics. In addition, the proposed research has implications for novel dietary and exercise recommendations and policy recommendations for the economically disadvantaged populations of Kentucky.

PI_NAMEs: PENNELL, KELLY G (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: Acceleration;Address;Aging;Appalachian Region;Awareness;Binding;Biochemical;Biological;Biological Markers;Biological Models;Biological Monitoring;Biomedical Research;Biomimetics;chemical stability;Chemicals;chronic inflammatory disease;Communication;Communities;community engaged research;community engagement;community intervention;community involvement;Complex;Consumption;Data;Data Analyses;data management;detection method;Diet;dietary;Diffusion;Disease;Disease Outcome;disorder prevention;disorder risk;Economically Deprived Population;Engineering;Environment;environmental chemical;environmental chemistry;Environmental Engineering technology;Environmental Health;Environmental Pollutants;Environmental Science;Evaluation;Exercise;experience;exposure pathway;Exposure to;Fiber;Fostering;Funding;Future;Goals;graphene;halogenation;Hazardous Substances;Health;healthy lifestyle;Human;human old age (65+);improved;Industry;innovation;insight;Intake;interdisciplinary approach;Interdisciplinary Study;Intervention;Iron;Kentucky;Life;Life Style;lifestyle intervention;Link;lipidomics;Membrane;Metabolic;metabolomics;Metals;Methods;Molecular;Nanostructures;National Institute of Environmental Health Sciences;next generation;novel;Nutrient;nutrition;organic contaminant;Outcome;Oxides;Pathway interactions;Physical activity;Physiological;Plants;Policy Maker;policy recommendation;pollutant;Polychlorinated Biphenyls;polyphenol;Predisposition;Pregnancy;prevent;Prevention;Prevention strategy;Primary Prevention;Problem Sets;programs;Recommendation;remediation;Research;Research Project Grants;Resources;Risk;Risk Assessment;Risk Management;Science;Scientist;Services;Site;Social isolation;Superfund;superfund chemical;superfund site;System;Techniques;Technology;Tetrachloroethylene;tool;Toxic effect;Toxicant exposure;Training;Translational Research;Trichloroethylene;Universities;vulnerable community;Vulnerable Populations

PROJECT_TITLE: Nutrition and Superfund Chemical Toxicity


PHR: PROJECT NARRATIVE The Administrative Core of the UK-SRC will continue to promote problem-based, solution-oriented research to reduce exposure and/or negative health impacts associated with exposure to a subclass of persistent halogenated chemicals (e.g. PCBs, TCE, and PFAS). This will be accomplished by using an innovative transdisciplinary research approach that brings together biomedical and environmental scientists, engineers, and trainees using an integrative administrative structure that links together individual projects and cores. The Administrative Core will ensure the continued relevance of the proposed research through bi-directional communication with the SRP and SRP staff, academia, the general public and relevant federal and state communities of practice (e.g. EPA, ATSDR, KYDEP) as well as communities of impact in Appalachia.

PI_NAMEs: HENNIG, BERNHARD  (contact)

PROJECT_TERMS: Academia;Address;Advisory Committees;Analytical Chemistry;Animal Model;Animals;Appalachian Region;arm;Biological Monitoring;Biomedical Research;Chemicals;clinical center;Clinical Sciences;Communication;Communities;community engagement;Community of Practice;Complex;Coupled;crosslink;Data;Data Analyses;data integration;data management;Databases;Dedications;design;Detection;Development;disorder risk;Educational workshop;Engineering;Ensure;Environment;Environmental Engineering technology;Environmental Exposure;Environmental Health;Environmental Science;Evaluation;Event;Exercise;experience;Exposure to;Funding;General Population;Goals;Government Agencies;Grant;halogenation;Health;healthy lifestyle;Human;Human Resources;improved;Individual;Industry;Information Dissemination;Infrastructure;innovation;Internships;Intervention;investigator-initiated translational research;Kentucky;Leadership;life span;Life Style;Link;Maintenance;materials science;meetings;member;Mentorship;multidisciplinary;National Institute of Environmental Health Sciences;novel;nutrition;Physical activity;pollutant;Poly-fluoroalkyl substances;Polychlorinated Biphenyls;Positioning Attribute;prevent;Prevention;Process;process improvement;Productivity;programs;remediation;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Risk;Role;Science;Scientist;Structure;Superfund;superfund chemical;Targeted Research;Technology;technology development;Technology Transfer;Testing;Toxic effect;Toxicity Tests;Training;Training Activity;Translating;Translational Research;Translations;United States National Institutes of Health;Universities;Water;webinar

PROJECT_TITLE: Administration Core


NIH_SPENDING_CATS: Bioengineering;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE Exposure to environmental chemicals increases the risk of many non-communicable human diseases. The UK- SRC serves our stakeholders and the broader objectives of the Superfund Research Program by conducting studies to understand mechanisms linking exposure to environmental chemicals with human disease risk, lifestyle based approaches to mitigate these risks and strategies for improved sensing and remediation of toxic environmental chemicals. This core component provides UK-SRC investigators with measurements of these environmental chemicals, their metabolites and degradation products and other biological molecules of relevance to human health.

PI_NAMEs: MORRIS, ANDREW J (contact)

PROJECT_TERMS: Address;Amendment;Analytical Chemistry;analytical method;Basic Science;Biological;Biological Markers;Biological Monitoring;Biological Process;Businesses;Cardiovascular Diseases;cardiovascular disorder risk;Chemicals;Clinical;Clinical Management;clinical translation;Cohort Studies;Collaborations;Communities;computerized data processing;Consent;Coupled;Data Analyses;Data Analytics;data management;Data Reporting;Data Science;Data Storage and Retrieval;Detection;Development;Diet;Diet and Nutrition;Disease;disorder risk;Doctor of Philosophy;Ensure;environmental chemical;environmental chemical exposure;Environmental Engineering technology;Environmental Exposure;Environmental Health;environmental intervention;Environmental Pollutants;Environmental Science;Equipment;Evaluation;Exercise;experience;Exposure to;Funding;Gas Chromatography;Goals;Grant;Health;High Pressure Liquid Chromatography;Human;human disease;Human Resources;improved;In Vitro;Institutional Review Boards;instrument;instrumentation;interest;Intervention;Investigation;Laboratories;laboratory facility;Lead;Life Style;Link;lipidomics;Liquid Chromatography;Literature;Malignant Neoplasms;Management Information Systems;mass spectrometer;Mass Spectrum Analysis;Measurement;Medical center;metabolomics;Methods;National Institute of Environmental Health Sciences;nutrition;offspring;operation;Outcome;pollutant;population health;Pre-Clinical Model;preclinical study;Preparation;Procedures;programs;Protocols documentation;Publications;quality assurance;Quality Control;Reaction;remediation;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resolution;Risk;risk mitigation;Role;Sampling;Schedule;Service provision;Services;Soil;Source;stressor;Superfund;superfund chemical;Support System;System;Technology;Testing;Toxic effect;Toxic Environmental Substances;United States Department of Veterans Affairs;United States National Institutes of Health;Veterans Health Administration;Vulnerable Populations;Water;water sampling;Work

PROJECT_TITLE: Biomonitoring and Environmental Analytical Chemistry Core


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: WILMINGTON

ORG_NAME: NEMOURS CHILDREN'S HOSPITAL, DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE This project seeks to develop and evaluate a comprehensive group model of well child care for mothers in treatment for opioid use disorder and their children. The healthcare model proposed in this application seeks to positively impact key healthcare and health outcomes by addressing critical gaps in parenting knowledge, behaviors, and engagement in care. This line of research will have broad applicability to communities and health care systems affected by high rates of maternal opioid use disorder; if implemented at scale this model has potential to substantially impact early childhood outcomes, serving as a critical role in mitigating the intergenerational impact of the opioid crisis.

PI_NAMEs: GOYAL, NEERA  (contact);SHORT, VANESSA L

PROGRAM_OFFICER_NAME: CHEW, EMILY

PROJECT_TITLE: Group well child care intervention for infants of mothers in treatment for opioid use disorder

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Obesity and Type 2 diabetes have reached epidemic proportions. We will investigate the molecular mechanisms by which glycogen serves a role as a master regulator of metabolism in physiological and pathological states.

PI_NAMEs: SALTIEL, ALAN R. (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Adipocytes;Adipose tissue;Adrenergic Agents;Adrenergic Agonists;Apoptosis;Attention;CASP6 gene;Cells;cohort;cold stress;Complex;conditional knockout;Cues;Cyclic AMP-Dependent Protein Kinases;Diabetes Mellitus;dietary;Disease;energy balance;Energy Metabolism;Ensure;Epidemic;Expenditure;experimental study;Fasting;Fatty acid glycerol esters;Fatty Acids;fatty liver disease;Feedback;feeding;Gene Expression;gene induction;Generations;Genes;Glucose;glucose metabolism;Glucosephosphates;Glycogen;Glycogen (Starch) Synthase;glycogen metabolism;Glycogenolysis Inhibition;Health;Heart Diseases;Hepatic;Hepatocyte;High Fat Diet;Homeostasis;In Vitro;in vivo;Inflammation;Injections;innovation;insight;Insulin;Investigation;Knock-out;Knockout Mice;lipid biosynthesis;lipid metabolism;Lipids;Liver;Mediating;Metabolic;Metabolic stress;Metabolism;Mitochondria;Molecular;mouse model;Mus;Muscle;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;obese patients;Obesity;Obesity Epidemic;overexpression;Overnutrition;oxidation;p38 Mitogen Activated Protein Kinase;Pathologic;Pathway interactions;Patients;Phosphoric Monoester Hydrolases;Phosphorylases;Physiological;Play;Process;protein activation;Reactive Oxygen Species;Regulation;Repression;response;restoration;Role;Scaffolding Protein;sensor;Signal Transduction;Specificity;Stress;subcutaneous;Testing;Thermogenesis;Tissues;TSC1/2 gene;Uncertainty;Up-Regulation

PROJECT_TITLE: Regulation of glycogen in health and disease

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD);Nutrition

PHR: PROJECT NARRATIVE The Data Management and Analysis Core (DMAC) of the University of Kentucky Superfund Research Center (UK-SRC) provides an integral new resource by functioning as a nexus for interactions across projects and cores. It systematically integrates data assets through the entire lifecycle of the grant and facilitates interaction of investigators and trainees to assist them in conducting research that addresses Superfund mandates. The DMAC will foster data sharing within and beyond UK-SRC, including researchers, as well as community stakeholders, and governmental agencies committed to protecting public health from the adverse effects of hazardous chemicals.

PROJECT_TERMS: Academy;Acceleration;Address;Adverse effects;Animals;application programming interface;Awareness;Basic Science;biomedical informatics;Biometry;Chemicals;Collaborations;Common Data Element;Communities;community engagement;Complex;Computational Science;Consensus;Data;Data Analyses;data archive;Data Coordinating Center;data dashboard;data dictionary;data ecosystem;data integration;data management;data quality;data resource;Data Science;Data Scientist;Data Set;data sharing;data standards;data tools;Deposition;design;Development;Discipline;Documentation;E-learning;Educational workshop;Electronics;Ensure;Environment;Environmental Health;Environmental Science;experience;experimental study;Formulation;Fostering;Goals;Grant;Hazardous Chemicals;Hazardous Substances;improved;Information Resources;Infrastructure;innovation;Interdisciplinary Study;interoperability;investigator-initiated translational research;Kentucky;Knowledge;Knowledge Discovery;Life Cycle Stages;meetings;member;Metadata;Methods;National Institute of Environmental Health Sciences;nutrition;Online Systems;Ontology;Outcome;Planet Earth;Population;Problem Solving;Process;programs;Protocols documentation;Public Health;quality assurance;Quality Control;Registries;remediation;repository;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Risk;Science;Scientist;Secure;Series;Site;Superfund;superfund chemical;symposium;Technology;Terminology;Testing;tool;Toxic effect;Training;training data;training opportunity;training project;Translational Research;Universities;Validation;webinar;Work

PROJECT_TITLE: Data Management and Analysis Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Lung Cancer;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Tobacco use and secondhand smoke exposure (SHSe) represent critical health disparities in low- and middle-income countries (LMICs); Armenia (AM) and Georgia (GE) represent the 11th and 6th highest smoking rates in men globally (51.5% and 55.5%, respectively), but have low rates of smoking in women (1.8% and 7.8%) and few smoke-free homes (SFHs; 38.6%), which can reduce SHSe and tobacco use rates. This proposal builds on our ongoing collaborations with national public health organizations in AM and GE and advancements in local public health infrastructure; we aim to adapt our team’s evidence-based SFH intervention for homes in AM and GE, develop capacity to deliver the intervention via local community partners and the national quitlines, and test the intervention in a hybrid effectiveness-implementation RCT. This work will advance our long-term goals of building the knowledge base informing strategies to reduce global tobacco-related disparities, as well as the implementation and scale-out of evidence-based interventions in LMICs.

PI_NAMEs: BERG, CARLA J (contact);KEGLER, MICHELLE C

PROGRAM_OFFICER_NAME: JALLOW, FATOU

PROJECT_TERMS: Address;Adoption;Adult;American;Armenia;Back;Behavioral;brief intervention;Cancer Control;cancer prevention;Centers for Disease Control and Prevention (U.S.);Child;Chronic Disease;cigarette smoke;Collaborations;Communities;community engaged approach;community organizations;community partners;community setting;cost effective;cost effectiveness;Country;Data;design;disorder prevention;Disparity;Effectiveness;effectiveness evaluation;effectiveness-implementation RCT;effectiveness/implementation hybrid;Ensure;environmental tobacco smoke exposure;evidence base;Evidence based intervention;Focus Groups;follow up assessment;follow-up;Funding;global health;Goals;Health;health disparity;health organization;Home;Household;Human Resources;Imagery;Individual;Infrastructure;innovation;Intervention;intervention delivery;intervention refinement;Interview;knowledge base;low and middle-income countries;Low income;Maintenance;member;men;Methods;Modeling;Motivation;National Cancer Institute;non-smoker;non-smoking;Participant;Patient Recruitments;Population;Primary Care;primary outcome;process evaluation;Professional counselor;programs;Public Health;quitline;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Research;Resource-limited setting;scale up;Schools;Science;secondary outcome;Self Efficacy;Smoke;Smoke-free home;smoke-free policy;Smoker;Smoking;Smoking Behavior;smoking cessation;smoking prevalence;Source;System;Testing;theories;Tobacco;Tobacco use;Training;Translating;United States National Institutes of Health;Universities;web site;Woman;Work

PROJECT_TITLE: Implementing a Scalable Smoke-free Home Intervention in Armenia and Georgia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-J(02)M]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Physical Activity;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE  The Community Engagement Core (CEC) works to achieve public health benefits within communities and  supports the UK-SRC by encouraging Superfund Research Program (SRP) stakeholders to protect their health  from exposure to environmental contaminants by consuming a healthy diet and increasing physical activity to  reduce the bodily amount and toxicity of hazardous substances (mandate #4). The proposed CEC prevention/  intervention activities are community-driven, solution-oriented programs that translate the science of the UK-  SRC and addresses the needs of SRP stakeholders with concerns regarding exposure to hazardous  substances. The CEC programs achieve this by providing community residents with the opportunity to improve  nutrition, increase physical activity and enhance environmental health literacy among community residents.

PI_NAMEs: BREWER, DAWN  (contact)

PROJECT_TERMS: Address;Adopted;Affect;Age;Air Pollution;Area;Back;Behavior;behavior change;Biological;Chemicals;Chronic Disease;Coal Mining;Communication;Communities;community center;community collaboration;community engagement;community led intervention;community partners;Consumption;Country;County;design;Development;Drug Metabolic Detoxication;Education;environmental change;Environmental Hazards;Environmental Health;Environmental Pollutants;Environmental Pollution;Evaluation;evidence base;experience;Exposure to;Family;farmers markets;Focus Groups;Fostering;Goals;good diet;Hazardous Substances;Health;Health behavior;Health behavior change;Health Benefit;health knowledge;health literacy;healthy lifestyle;Home;improved;Individual;innovation;Intervention;Interview;Journals;Kentucky;Kidney;Knowledge;Lead;life span;Life Style;Liver;meetings;Methods;Modeling;Needs Assessment;novel;nutrition;older adult;Outcome;Peer Review;Physical activity;Physiological;Plants;Policies;pollutant;Poly-fluoroalkyl substances;Polychlorinated Biphenyls;Population;Population Growth;Populations at Risk;Predisposition;prevent;Prevention;Prevention strategy;programs;Public Health;rapid growth;Recommendation;Reporting;Research;Research Activity;Research Project Summaries;Resources;Risk;Risk Reduction;Science;Scientist;Services;Site;social;Solvents;Superfund;superfund chemical;superfund site;Surveys;symposium;System;tool;tool development;Toxic effect;Translating;United States;Universities;vulnerable community;walking program;Water Pollution;Work;Youth

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Nutrition

PHR: PROJECT NARRATIVE The focus of University of Kentucky Superfund Research Center (UK-SRC) is committed to developing an in- depth understanding of environmental health associated with exposure to organic pollutants as well as the development of protective technologies to aid in reduction of such exposure incidents. The proposed interdisiplinary training activites of the UK-SRC will be led and coordinated by the Research Experience and Training Coordination Core to successfully train skilled individuals who will positively impact our environmental health and the overall health of our nation.

PI_NAMEs: HILT, JAMES ZACH (contact)

PROJECT_TERMS: Address;Affect;Bioinformatics;career;career development;Clinical;clinical center;Clinical Sciences;Collaborations;Communication;Communities;community engagement;Complex;Creativeness;Data Analyses;Data Collection;data management;Data Science;data sharing;design;Development;Discipline;Disparate;Doctor of Philosophy;Education;Educational workshop;empowerment;Environmental Engineering technology;Environmental Health;Environmental Science;experience;Exposure to;flexibility;Funding;Goals;Government;Grant;halogenation;Health;Individual;Industrialization;Industry;innovation;interdisciplinary approach;Interdisciplinary Study;interest;Kentucky;Knowledge;laboratory experience;Laboratory Research;Leadership;Life Style;Location;Medical Ethics;meetings;Mentors;Methods;Mind;Modeling;Modernization;multidisciplinary;next generation;novel;nutrition;Outcome;outreach;Policies;pollutant;Positioning Attribute;Postdoctoral Fellow;Problem Solving;Productivity;programs;Public Health;Recording of previous events;recruit;remediation;Reporting;Research;Research Project Grants;Resources;responsible research conduct;Science, Technology, Engineering and Mathematics;Scientist;Series;Signal Recognition Particle;skills;skills training;Social Impacts;Source;STEM field;student training;Students;success;Superfund;superfund chemical;superfund site;Technology;Thinking;Toxic effect;Toxicology;Training;Training Activity;Training and Education;training opportunity;Training Programs;Translational Research;Universities;Water;webinar;Writing


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The aim of this proposal is to investigate a mechanism used by macrophages to label and detect target cells including cancer cells, pathogenic cells in inflammatory conditions, fibroblasts in fibrotic diseases and peritoneal adhesions, persistently infected cells, smooth muscle cells in atherosclerosis, and in cells reaching the end of their lifespan. We found that activated macrophages secrete a soluble form of calreticulin (CRT) that binds to asialoglycans thereby forming an ‘eat me’ signal on the surface of cancer cells or the other cells listed above that are then recognized and removed by phagocytosis. We will investigate the biochemical pathways leading to CRT secretion from macrophages and to asialoglycan exposure on the surface of target cells, and examine the scenarios in which this mechanism is utilized and may have therapeutic implications.

PI_NAMEs: WEISSMAN, IRVING L. (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Adhesions;Affect;Aging;Agonist;American Society of Clinical Oncology;Apoptotic;Asialoglycoproteins;Atherosclerosis;BCL2 gene;Binding;Binding Sites;Biochemical;Biochemical Pathway;Blocking Antibodies;Blood;Bone Marrow;C-terminal;calreticulin;cancer cell;cancer type;CD47 gene;Cell Communication;Cell Membrane Proteins;Cell secretion;Cell surface;Cells;Cellular biology;Clinical;Clinical Trials;Degenerative Disorder;Development;Disease;Disease remission;disorder prevention;Eating;Enzymes;Event;Excision;Exposure to;Extracellular Space;Fibroblasts;Generations;Glycoproteins;Hematopoietic stem cells;Heterogeneity;Homeostasis;Human;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Invaded;Investigation;KDEL Motif;Knowledge;Label;Lesion;leukemic stem cell;Life;life span;Ligands;lysyl-aspartyl-glutamyl-leucine;Macrophage;Macrophage Activation;Malignant Neoplasms;Mediating;Membrane;Molecular Chaperones;Multipotent Stem Cells;Mus;Neoplasms;neoplastic cell;Neuraminidase;neutrophil;new therapeutic target;Non-Malignant;nonalcoholic steatohepatitis;Normal tissue morphology;novel;overexpression;Pathogenicity;Pathologic;Pathway interactions;Peritoneal;Phagocytes;Phagocytosis;Phase;prevent;Process;Proteins;Proteolytic Processing;Proteomics;Publishing;receptor;Reporting;Research;Rest;Role;Sialic Acids;Sialoglycoproteins;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;Sterility;Surface;Systemic Scleroderma;Testing;Therapeutic;therapeutic development;Tissues;TLR3 gene;Toll-like receptors;Translating

PROJECT_TITLE: Programmed Cell Removal (PrCR) by Macrophages: recognition and phagocytosis of target cells

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Endocrine Disruptors;Liver Disease;Microbiome;Natural Products;Nutrition;Prevention

PHR: PROJECT NARRATIVE This project explores connections between two major public health concerns that are highly relevant to Superfund Research Program (SRP) stakeholders and the SRP: widespread contamination of the environment by a class of long-lasting toxic chemical contaminants known as PCBs and PFAS. These contaminants have been linked to a leading U.S. health challenge, cardiovascular diseases, and also linked to the liver and gut. The project addresses specifically SRP Mandate 4 by testing dietary interventions that may disrupt disease processes by stabilizing the gut bacteria and liver and reducing cardiovascular risks initiated by exposure to pollutants, particularly in people who reside near Superfund or other hazardous waste sites where PCBs and other pollutants are prevalent.

PI_NAMEs: ZAYTSEVA, YEKATERINA  (contact)

PROJECT_TERMS: Acceleration;Acute;Address;Amines;animal data;Animal Model;Antibiotics;Atherosclerosis;atherosclerosis risk;Binding;biobank;Biological;Biological Markers;Blood Vessels;Body System;Cardiometabolic Disease;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cause of Death;Ceramides;chemical stability;Chemicals;choline deficient diet;Chronic;chronic inflammatory disease;Data;Data Set;Development;Diet;Dietary Fiber;Dietary Intervention;Dioxins;Disease;disorder risk;Down-Regulation;Endothelium;Environment;Environmental Engineering technology;Environmental Exposure;Environmental Science;Enzymes;Epigallocatechin Gallate;Event;experimental study;exposed human population;Exposure to;Fiber;Functional disorder;Future;Gene Expression;Genes;Goals;Green tea;gut bacteria;gut microbiota;halogenation;Hazardous Waste Sites;Health;Hepatic;Hepatocyte;Human;In Vitro;in vivo;Inflammation;Inflammatory;Insulin Resistance;Inulin;Life Cycle Stages;Link;lipid metabolism;Lipids;Liver;Liver Dysfunction;liver injury;Low Density Lipoprotein Receptor;Macrophage;Mediating;Metabolic;Metabolic dysfunction;metabolic profile;Metabolism;metabolomics;Methionine;Modeling;Molecular;Mus;NF-kappa B;Nutrient;nutrition;Organ;Outcome;oxidation;Oxidation-Reduction;Oxides;Pathology;Peripheral;Permeability;persistent organic pollutants;Persons;Plants;Plasma;Poison;pollutant;Poly-fluoroalkyl substances;Polychlorinated Biphenyls;polyphenol;Population;Pre-Clinical Model;prebiotics;prevent;Process;Production;programs;Public Health;Reporting;Research;response;Risk;Sampling;Signal Pathway;Signal Transduction;Sphingolipids;stable isotope;Stains;Superfund;superfund chemical;systemic inflammatory response;Technology;Testing;Toxic effect;toxicant;transcriptomics;United States;Vascular Endothelial Cell;vascular inflammation;Volatile Fatty Acids

PROJECT_TITLE: Superfund Chemicals, Nutrition, and Multi-Organ Cardiovascular Risk


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: BOISE

ORG_NAME: BOISE STATE UNIVERSITY

ORG_STATE: ID

PHR: PROJECT NARRATIVE STATEMENT Research described in this application will validate tools for determining chain flipping rate constants in AHL quorum signal synthase enzymes. This information is critical to achieve selectivity in quorum sensing inhibition. Small molecules that selectively modulate quorum sensing will provide valuable leads for developing novel antivirulent compounds in antibacterial therapy.

PI_NAMEs: NAGARAJAN, RAJESH  (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Active Sites;Acyl Carrier Protein;Address;Affinity;Anti-Bacterial Agents;antimicrobial;Bacteria;Bacterial Infections;Binding;Binding Proteins;Biological Assay;Biological Models;Bromides;Carrier Proteins;Cells;Chemicals;Core Protein;Coupling;crosslink;Cysteine;Data;design;Development;Docking;Electrostatics;Enzymes;Fluorescence;fluorophore;Genetic Code;Gram-Negative Bacteria;high throughput screening;homoserine lactone;in vivo;inhibitor;Investigation;Kinetics;Label;Laboratories;Literature;Measures;Mediating;Medicine;Methods;Microbial Biofilms;Molecular;Multi-Drug Resistance;mutant;Mutation;novel;Physiological;Positioning Attribute;Preparation;prevent;Process;Production;Proteins;quorum sensing;Reaction;Reporting;Research;S-Adenosylhomocysteine;S-Adenosylmethionine;screening;Signal Transduction;single molecule;Site;small molecule;small molecule inhibitor;Specificity;Sulfhydryl Compounds;Titrations;tool;Toxin;Tryptophan;Virulence

PROJECT_TITLE: Chemical tools to investigate chain-flipping in quorum signal synthases

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Once a T cell reaches a site of infection, the cell must decide how long to reside there before returning to circulation. This “stay or go” decision shapes the immediate response to infection, as well the type of memory response that is established. Here, we will address how T cells are drawn out of inflamed tissues, as well as track the fate of the cells that have left these tissues.

PI_NAMEs: SCHWAB, SUSAN RUTH (contact)

PROGRAM_OFFICER_NAME: LEITNER, WOLFGANG W

PROJECT_TERMS: Address;Animals;cell motility;Cell Physiology;cell type;Cells;Chronic;Circulation;clinically relevant;Communities;Cues;CXCR4 gene;Disease;disease model;draining lymph node;Endothelium;Enterobacteria phage P1 Cre recombinase;exhaustion;Flow Cytometry;Gene Expression;Gene Targeting;Genes;genetic manipulation;Grant;Height;Image;Immune;Immune response;Immunology;In Vitro;Individual;inducible Cre;Infection;Inflammation;Inflammatory;Inflammatory Infiltrate;inhibitor;Injections;Inorganic Phosphate Transporter;interest;irritation;Left;Light;Lipids;Location;Lymph;lymph nodes;Lymphatic;Memory;Modeling;monocyte;mouse model;Mus;novel;Organ;Oxazolone;Periodicals;Phase;Play;prevent;receptor;Regulation;Reporter;Reporting;Reproducibility;response;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Site;Skin;Specificity;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;Staphylococcus aureus;Staphylococcus aureus infection;T cell regulation;T cell response;T-Cell Development;T-Lymphocyte;Testing;Thymus Gland;Time;tissue resident memory T cell;Tissues;tool;Vaccine Design;vaccine strategy;Visualization

PROJECT_TITLE: Regulation of T cell exit from non-lymphoid tissues

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Endocrine Disruptors;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Pregnancy;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE Obesity and diabetes are at epidemic levels, and the toxicity of environmental contaminants during perinatal development could be a significant contributor to these trends. The proposed studies will offer innovative new insights to understanding the role of exercise in mitigating the health impacts of in utero contaminant exposures. Project 2 clearly addresses three of the Superfund Research Program primary objectives: Mandate 1, “advanced techniques for detection, assessment and evaluation of the effect of hazardous substances on human health”, Mandate 2, “methods to assess the risks to human health presented by hazardous substances”, and Mandate 4, “methods to reduce the amount and toxicity of hazardous substances.”

PI_NAMEs: PEARSON, KEVIN JOSEPH (contact)

PROJECT_TERMS: Address;adipocyte differentiation;Adipocytes;Adolescent;Adult;Agonist;Aryl Hydrocarbon Receptor;Behavior Therapy;Biochemical;biological adaptation to stress;biomarker identification;blood glucose regulation;Body Composition;Cell Separation;Cells;Child;cohort;Collaborations;cost effective;dechlorination;detection method;Development;Diabetes Mellitus;diabetes risk;diphenyl;Discipline of Nursing;disorder risk;Endocrine Disruptors;Environmental Exposure;Environmental Impact;Environmental Pollutants;Epidemic;Erythroid;Evaluation;Exercise;exercise intervention;Exposure to;Fatty acid glycerol esters;Female;fetal;Funding;Future;Gender;Glucose Clamp;Glucose Intolerance;glucose uptake;Goals;halogenation;Hazardous Substances;Health;Home;Human;Human Development;Human Milk;Hyperinsulinism;impaired glucose tolerance;Impairment;improved;in utero;in vivo;Infant;innovation;insight;Insulin Resistance;insulin sensitivity;insulin signaling;Intervention;Kentucky;Knockout Mice;Life Style;lipid biosynthesis;Liver;male;Measures;Mesenchymal Stem Cells;Metabolic;Methods;Modeling;Molecular;mouse model;Mus;Muscle Cells;Neonatal;neonate;Nuclear;nutrition;Obesity;obesity development;obesity in children;obesity risk;obesogen;offspring;offspring obesity;Outcome;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;perfluorooctane sulfonate;perfluorooctanoic acid;Perinatal;perinatal development;Perinatal Exposure;Phenotype;Placenta;Play;pollutant;Poly-fluoroalkyl substances;Polychlorinated Biphenyls;postnatal;Predisposition;Pregnancy;prenatal exposure;Process;programs;Research;Risk Assessment;Role;Running;Sampling;sedentary;Serum;specific biomarkers;Superfund;superfund chemical;Testing;Thinness;Time;Tissues;Toxic effect;transcription factor;trend;Umbilical cord structure;Universities;Work

PROJECT_TITLE: Postnatal Complications and Interventions against Halogenated Organics during Pregnancy


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Knowledge about the dispersal of Plasmodium falciparum parasites is essential for the design of effective interventions to to control malaria. The proposed work leverages new genomic methods to conduct a comparative analysis of approaches to study spatial movement of parasites and transmission chains in low and high transmission settings, where different methods may be necessary. The proposed award will support the development of a research platform that employs translational genomics to improve our understanding of parasite biology, inform interventions for malaria control and elimination, and supports the career development of both the investigator and his trainees.

PI_NAMEs: JULIANO, JONATHAN J (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Address;Africa;Africa South of the Sahara;Award;Biological Assay;Biology;career;career development;Clinic;Clinical Sciences;college;Communicable Diseases;Communities;comparative;Complementarity Determining Regions;Complex;cost effective;Country;Cross-Sectional Studies;deep sequencing;Democratic Republic of the Congo;design;Detection;Development;Disease;Doctor of Philosophy;doctoral student;Educational process of instructing;effective intervention;Elements;Ensure;Environment;Equity;Evolution;Exclusion;experience;Faculty;Fellowship Program;Fostering;Funding;Genes;Genetic;Genetic Markers;Genetic Variation;Genome;genome sequencing;genomic tools;Genomics;Genotype;Geography;Gills;Goals;Hot Spot;Household;improved;induced pluripotent stem cell;Infection;Instruction;International;Intervention;Knowledge;Leadership;learning strategy;Location;London;Malaria;malaria infection;malaria transmission;medical schools;member;Mentors;Mentorship;Methodology;Methods;Mid-Career Clinical Scientist Award (K24);migration;Modeling;Molecular;Movement;Multigene Family;next generation sequencing;North Carolina;Parasites;Pathogenesis;patient oriented research;Pattern;Persons;Plasmodium falciparum;Population;Positioning Attribute;Postbaccalaureate;professor;programs;Public Health;Publishing;recruit;Research;Research Personnel;Resistance;Resolution;Resources;Risk Factors;Rural;rural area;Sampling;Schools;Site;skills;Structure;Students;targeted sequencing;Technology;Time;tool;Training;Translating;translational genomics;Translational Research;transmission process;United States National Institutes of Health;Universities;urban setting;Urbanicity;whole genome;Work;Zanzibar

PROJECT_TITLE: Mentoring in Translational Malaria Genomics

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


PHR: PROJECT NARRATIVE The persistence of toxic pollutants at Superfund sites poses a major environmental public health problem and a serious need for environmental solutions to reduce risk. Our research is expected to lead to cost-effective technologies for remediation of chemicals, such as TCE, PCE and PCBs, to nontoxic and biodegradable intermediates and for superfast sorption of PFAS compounds with responsive polymer materials. Our approaches to develop new polymer membrane and 2D-based materials to detoxify water and low energy consuming adsorption/desorption technologies should lead to an advanced technology solution in the field of remediation science and engineering from Superfund sites to water utility companies.

PI_NAMEs: BHATTACHARYYA, DIBAKAR  (contact)

PROJECT_TERMS: Adsorption;Advanced Development;Aftercare;Area;Attention;Biomedical Research;Carbon;Carbon Tetrachloride;Catalysis;Catalytic Domain;Chemicals;Chloroform;Collaborations;contaminated water;cost;cost effective;design;Detection;Development;drinking water;Drug Metabolic Detoxication;Energy consumption;Engineering;Environment;Environmental Health;Fiber;food science;Funding;Gel;global environment;Goals;graphene;ground water;halogenation;Hazardous Waste Sites;Health;Heating;Human;Hydrogels;Individual;Industrialization;International;Iron;Kentucky;magnetic field;Magnetism;magnetite ferrosoferric oxide;materials science;Membrane;metallicity;Metals;Methods;microbial;nanocomposite;nanoparticle;nanoscale;nanosized;Nanostructures;Natural regeneration;novel;nutrition;Nutritional Science;Oxidants;Oxides;particle;pollutant;Poly-fluoroalkyl substances;Polychlorinated Biphenyls;Polymers;prevent;Property;Public Health;reaction rate;remediation;Research;Risk;Risk Reduction;Science;sensor;Site;Soil;Solvents;Source;Sulfate;Superfund;superfund chemical;superfund site;Surface;System;Techniques;Technology;Temperature;Tetrachloroethylene;Toxic effect;Toxicant exposure;Trichloroethylene;Water;water sampling

PROJECT_TITLE: Responsive Membranes and Advanced Materials for Sensing and Remediation of Halo-organics


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE Past drug screens identified small molecules that selectively inhibited only T cell function as potential treatment for autoimmune diseases. Our data establish these molecules target Exportin-1 (XPO1), and our aims use organic synthesis and chemical biology to understand and optimize a novel profile of XPO1 partial antagonist for use in autoimmune diseases.

PI_NAMEs: ADAMS, DREW JAMES (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Address;Adrenal Cortex Hormones;Affect;Affinity;Animal Model;antagonist;Autoimmune Diseases;Binding;Binding Proteins;Biochemical;Biological Assay;Biology;cancer cell;Cancer Patient;Cancer Relapse;cancer therapy;Cell Death;Cell Death Induction;Cell Physiology;Cell Survival;cell type;Cellular Assay;cellular targeting;Centromere;Centrosome;Chromatin;Client;Cyclosporine;Cysteine;Cytoplasm;cytotoxic;Cytotoxic Chemotherapy;cytotoxicity;Data;Disease;Dissociation;Dose;drug discovery;Drug Screening;Drug Targeting;exportin 1 protein;FDA approved;forging;Genetic Transcription;Genome;genomic locus;Graft Rejection;graft vs host disease;high throughput screening;Human;Immune;immune modulating agents;Immune response;Immunology;Immunosuppression;Impairment;In Vitro;in vivo;Inflammatory Response;inhibitor;kidney dysfunction;Label;Ligands;Mediating;Modeling;mouse model;Multiple Myeloma;Natural Products;novel;Nuclear;Nuclear Export;nuclear factors of activated T-cells;Oncology;Organic Chemicals;Organic Synthesis;Pancytopenia;Pathologic;Patients;Pharmaceutical Chemistry;Pharmacology;Phenotype;Play;Pre-Clinical Model;prevent;Prior Therapy;Process;protein protein interaction;Proteins;Pulmonary Fibrosis;refractory cancer;Regimen;Relapse;Research Personnel;Rheumatoid Arthritis;Role;screening;side effect;Signal Transduction;Site;small molecule;Structure;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Tissue Transplantation;Tissues;Transcription Factor AP-1;Work;X-Ray Crystallography

PROJECT_TITLE: Selective Inhibitors of T Cell Activation Target Exportin-1 at Cys528 to Suppress Pathological T Cell Activation

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Endocrine Disruptors;Foodborne Illness;Health Effects of Indoor Air Pollution;Nutrition;Prevention

PHR: PROJECT NARRATIVE The overarching goal of this project is to advance fate and transport research to identify and reduce exposure risks associated with trichloroethene (TCE), tetrachloroethene (PCE), and PFAS. Field study results verify and calibrate new models that predict contaminant mass flux associated with damaged subsurface piping networks, which serve as preferential pathways for contaminants to be transported throughout communities. Evidence- based practices serve as a framework to promote environmental health literacy, so that community stakeholders, representatives from regulatory agencies, and industry groups can provide information to develop solutions that will ensure Superfund mandates are addressed and public health is protected.

PROJECT_TERMS: Address;aged;Aging;Air;Analytical Chemistry;base;Biological Monitoring;Biomedical Research;Calibration;California;Communication;Communities;community engagement;Computer Models;contaminant transport;Coupled;Data;Data Analyses;data interoperability;data management;data modeling;Deterioration;drinking;drinking water;engineering design;Ensure;Environment;Environmental Engineering technology;Environmental Exposure;Environmental Hazards;Environmental Health;Environmental Pollutants;Environmental Science;epidemiology study;Equation;Ethylenes;Evidence based practice;field study;Foundations;Fracture;Gases;Goals;ground water;Hazardous Waste;Health;health literacy;hookah;Human;Individual;indoor air;Indoor Air Quality;Industry;informant;Infrastructure;Inhalation Exposure;Interview;Joints;Kentucky;Knowledge;mass flux;Measurement;Measures;Membrane;Modeling;North Carolina;novel;nutrition;Outcome;Outcome Study;Pathway interactions;Policies;Poly-fluoroalkyl substances;Polymers;predictive modeling;pressure;prevent;Public Health;Regulation;Reporting;Research;research facility;Research Project Grants;Risk;Risk Management;Risk Reduction;Route;Sampling;Science;sensor;sensor technology;Services;Site;stakeholder perspectives;Superfund;superfund chemical;superfund site;Surveys;System;Techniques;Temperature;Testing;Tetrachloroethylene;Time;tool;Toxic effect;Transcend;Translational Research;Transport Process;Trichloroethylene;Uncertainty;United States;vapor intrusion;ventilation;Volatilization;Water;water quality;Water Supply

PROJECT_TITLE: Fate and Transport of Contaminants in Aging Piping Systems


NIH_SPENDING_CATS: Infectious Diseases;Lung

ORG_CITY: ORLANDO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: There is intense interest in identifying innate immune mechanisms, such as Complement, that are involved in controlling viruses, particularly those which establish persistent or prolonged infections. Our work on C’ resistance during persistent infections will have strong potential to inform future therapeutics, given: 1) the long-standing clinical impact of prolonged respiratory infections, 2) that polymorphisms in C’ genes can correlate with severity of viral infections (39, 42) and 3) that new clinical trials are underway with drugs that modulate C’ responses. .

PI_NAMEs: PARKS, GRIFFITH D. (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Acute;acute infection;Air;Binding;Biochemical;Biological Assay;Cell Culture Techniques;Cell Line;Cell Survival;Cells;chronic infection;Clinical;Clinical Trials;Complement;Complement Factor H;Complement Inactivators;conditioning;Cytolysis;Data;Drug Modulation;Engineering;Environment;Epithelial Cells;Fibrinogen;Future;gene complementation;Genetic Polymorphism;Genome;Goals;Human;In Vitro;Infection;Inflammation;inhibitor;innate immune mechanisms;innate immune pathways;Innate Immune System;interest;Liquid substance;Lung;Lung infections;Mediating;Mumps virus;parainfluenza virus;Paramyxovirus;pathogen;Pathway interactions;Population;Production;Proteomics;prototype;recruit;Resistance;respiratory;respiratory infection virus;Respiratory System;Respiratory Tract Infections;response;RNA Virus Infections;Role;Rubulavirus;Rubulavirus Infections;Severities;sulfated glycoprotein 2;Surface;Testing;Therapeutic;Time;Trachea;transcriptomics;Variant;Viral;Viral Respiratory Tract Infection;Virion;Virus;Virus Diseases;Virus Replication;Vitronectin;Work

PROJECT_TITLE: Complement Resistance Acquired During Acute to Persistent Rubulavirus Infection

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


ORG_CITY: STONY BROOK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: NARRATIVE This proposed program leverages the wealth of molecular tools and experimental approaches that we have developed along the years to study cell-to-cell transport of plant viruses and roles of protein ubiquitylation/deubiquitylation in plant-pathogen interactions to research a new (and, so far, completely unresearched) level of regulation of intercellular transport through plasmodesmata by reversible action of ubiquitin writers and erasers of the plant cell.

PI_NAMEs: CITOVSKY, VITALY H (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Address;Agrobacterium;Bacteria;Biology;Carrier Proteins;cell motility;Cells;epigenetic regulation;Gene Expression Regulation;Genes;Genetic Transformation;Goals;histone modification;innovation;intercellular connection;Knowledge;Laboratories;Life Cycle Stages;macromolecule;Mammals;Molecular;Movement;Nanotubes;Nucleic Acids;pathogen;Pathway interactions;Plant Model;plant virus movement protein;Plant Viruses;Plants;Plasmodesmata;programs;Proteins;Regulation;Research;response;Role;tool;Transport Process;Ubiquitin;ubiquitin isopeptidase;ubiquitin-protein ligase;Viral

PROJECT_TITLE: Writers and Erasers of Ubiquitin Moieties in Control of Cell-to-Cell Transport in Plants

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Contraception/Reproduction;Infertility;Regenerative Medicine;Women's Health Research

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Narrative Congenital and acquired structural uterine defects are the cause of combined miscarriage and uterine factor infertility in around 25% women. This study will explore the use of bioengineered implants to repair structural and functional uterine defects in a primate model.

PI_NAMEs: ATALA, ANTHONY  (contact);WILLIAMS, JAMES KOUDY

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TITLE: Bioengineered Tissues For Uterine Reconstruction

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza

ORG_CITY: ATLANTA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative The overarching goal of this application is to develop a single “pan-respiratory” mRNA-encoded Cas13 drug for treating viral respiratory infections, but with a focus on the three most impactful respiratory viruses in circulation, RSV, influenza and SARS-CoV-2. Multiple Cas13 nucleases will be evaluated, and mechanisms of action investigated; efficacy will be demonstrated with all three pathogens in rodent infection, co-infection and transmission models. Overall, we feel this approach and RNA-based platform have the potential to alter the paradigm for how viral infections are treated.

PI_NAMEs: SANTANGELO, PHILIP J (contact);ZURLA, CHIARA

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Address;Animal Model;Anti-viral Agents;antiviral drug development;Binding;Biotechnology;Circulation;Clustered Regularly Interspaced Short Palindromic Repeats;co-infection;Communicable Diseases;compare effectiveness;Conserved Sequence;Containment;COVID-19 pandemic;Doctor of Philosophy;Dose;Down-Regulation;drug development;drug efficacy;Enzymes;fluorescence imaging;Formulation;functional outcomes;Gene Transduction Agent;genomic RNA;Goals;Hamsters;Human;improved;In Vitro;in vitro Assay;in vivo;Individual;Infection;Influenza;Influenza A virus;Influenza B Virus;Innate Immune Response;innovation;lung basal segment;Messenger RNA;Modeling;mortality;mouse model;mRNA delivery;Mucous Membrane;Mus;Nature;Nebulizer;neutralizing antibody;nuclease;Organ;pathogen;Pathogenesis;Pharmaceutical Preparations;Predisposition;Publications;Qualifying;Resistance;resistance mutation;respiratory;respiratory pathogen;Respiratory System;respiratory virus;Ribonucleases;RNA;RNA Degradation;Rodent;Safety;SARS coronavirus;SARS-CoV-2 transmission;Seasons;Severe Acute Respiratory Syndrome;small molecule;success;Surface;Time;transcriptome sequencing;transmission process;ultra high resolution;Universities;vaccine efficacy;Vaccines;Variant;Viral;Viral Respiratory Tract Infection;viral RNA;Virus;Virus Diseases;Work

PROJECT_TITLE: mRNA-encoded Cas13 as a pan-respiratory antiviral

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(82)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Complementary and Integrative Health;Neurosciences

ORG_CITY: Boston

ORG_DEPT: BIOLOGY

ORG_NAME: TUFTS UNIVERSITY MEDFORD

PHR: NARRATIVE Rhythm perception is a core part of music processing and is central to music’s positive effect on a variety of neurological disorders, including Parkinson’s disease and dyslexia. Musical rhythm perception involves auditory-motor interactions which are not well understood at the circuit level. Our goal is to leverage the extensive knowledge of auditory and motor circuits in songbirds and behavioral methods for studying rhythm perception to investigate the contributions of motor regions to auditory rhythm processing.

PI_NAMEs: KAO, MIMI HSIAO FENG (contact);PATEL, ANIRUDDH D

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TITLE: Investigating Auditory-Motor Interactions During Rhythm Perception in a Small Animal Model


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Reward seeking is normally suppressed in inappropriate conditions, whereas opioid use and seeking often occur despite negative health and societal consequences. Activity in paraventricular thalamic neurons that project to the nucleus accumbens provides top-down inhibitory control over natural reward seeking, but the influence of opioid use on activity in this pathway is unknown. Here we determine the influence of opioid use on activity and plasticity in projection-specific paraventricular thalamic neurons and neuronal ensembles, and further determine the function of this pathway for suppression and expression of opioid-seeking behaviors.

PI_NAMEs: OTIS, JAMES M (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: addiction;Behavior;Behavioral;Behavioral Assay;Behavioral Paradigm;Biological Assay;Brain;Calcium;Conflict (Psychology);Consumption;Cues;Data;Drug usage;Electrophysiology (science);experience;experimental study;Extinction;feeding;Feeding behaviors;Fright;frontier;Head;Health;Heroin;heroin use;Image;in vivo calcium imaging;insight;Knowledge;Laboratories;Literature;Maintenance;Measures;Motivation;mu opioid receptors;Mus;Nature;Neurobiology;neuronal circuitry;Neurons;neurophysiology;novel;Nucleus Accumbens;Opioid;opioid use;opioid use disorder;optogenetics;patch clamp;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Publications;Relapse;relapse prediction;Research;Rest;restraint;reward anticipation;Rewards;Saline;Satiation;Self Administration;Slice;Stimulus;Structure of paraventricular nucleus of thalamus;Synapses;System;Testing;Thalamic structure;two-photon

PROJECT_TITLE: Thalamostriatal Circuitry in Opioid Seeking

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Patient Safety

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Program Director/Principal Investigator (Last, First, Middle): Crosby, Gregory J. Narrative Delirium is the most common complication of surgery and anesthesia in older patients and is associated with serious morbidity, including accelerated decline to dementia. Using biomarkers in plasma as well as MR imaging of cerebral volume, this proposal will investigate occult cerebral neurodegeneration pathology characteristic of Alzheimer’s disease and related disorders as a risk factor for postoperative delirium, and whether surgery- induced inflammation and delirium lead to neural injury that accelerates neurodegeneration and cognitive decline. By elucidating mechanisms of and plasma biomarkers for postoperative delirium, this work will help improve risk prediction and the cognitive outcomes of vulnerable older surgical patients. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

PI_NAMEs: CROSBY, GREGORY  (contact);CULLEY, DEBORAH J

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acceleration;Acute;Address;Age;Age Years;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloidosis;Anesthesia procedures;axon injury;Biological Markers;blood-based biomarker;Brain;brain magnetic resonance imaging;CD14 gene;cerebral atrophy;Cerebrum;Characteristics;Clinical;Cognition;Cognitive;Confusion;cost;Data;Delirium;Dementia;Development;Diagnosis;Distress;Future;Glial Fibrillary Acidic Protein;human old age (65+);Immune response;Impaired cognition;Impairment;improved;improved outcome;Inflammation;Inflammatory Response;Injury;innovation;late life;Lead;Light;Magnetic Resonance Imaging;Measures;monocyte;Morbidity - disease rate;Nerve Degeneration;nerve injury;neural;Neurobehavioral Manifestations;Neurobiology;Neurodegenerative Disorders;neurofilament;neuroinflammation;Neuropathogenesis;neuropathology;novel;Observational Study;older patient;Older Population;Operative Surgical Procedures;Outcome;Pathogenicity;Pathology;Patients;Perioperative Care;Plan B;Plasma;Positron-Emission Tomography;postoperative delirium;Postoperative Period;Predisposition;Prevalence;primary outcome;Principal Investigator;Procedures;programs;prospective;Proteome;Proxy;Recovery of Function;Research;Risk Assessment;Risk Factors;risk prediction;secondary outcome;Severities;Spinal Puncture;Spine surgery;Surgical complication;surgical risk;Symptoms;Syndrome;systemic inflammatory response;tau Proteins;Tauopathies;Testing;Time;transcriptome;UCHL1 gene;Validation;Work

PROJECT_TITLE: Preoperative Occult Neurodegeneration and Postoperative Delirium

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Clinical Research;Diabetes;Prevention

ORG_NAME: ADVENTHEALTH ORLANDO

PHR: PROJECT NARRATIVE Shiftwork is now recognized as a risk factor for type 2 diabetes, yet the mechanisms underlying these associations are poorly understood. Herein, we will test the hypothesis that real-world nightshift work impairs whole-body metabolic flexibility across the 24h day-night cycle, and that this will be associated with disrupted skeletal muscle clocks. To test this hypothesis, we will conduct rigorously controlled in-patient studies to assess and compare whole-body metabolic flexibility using innovative 24h metabolic chamber protocols, as well as skeletal muscle clock function by comparing diurnal shifts in skeletal muscle clock genes, in dayshift versus nightshift workers.

PI_NAMEs: ERICKSON, MELISSA  (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: Address;Affect;ARNTL gene;Biopsy;blood glucose regulation;burden of illness;Cell Culture Techniques;Chronic;Chronobiology;circadian;circadian biology;Circadian Dysregulation;circadian pacemaker;Clinical;clinical investigation;Clinical Research;cohort;Collaborations;Collection;Data;Dedications;Defect;design;Development;diabetes risk;Discipline of Nursing;Exercise;exercise intervention;experience;experimental study;Fasting;fatty acid oxidation;feeding;flexibility;Functional disorder;Funding;Future;Genes;Glucose;Glucose Intolerance;glucose metabolism;Human;impaired glucose tolerance;Impairment;In Vitro;Individual;innovation;Inpatients;Institution;Insulin Resistance;Intervention;K-Series Research Career Programs;Knowledge;Learning;Link;Mentors;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Methodology;Molecular;molecular clock;Muscle Fibers;muscle progenitor cell;Non-Insulin-Dependent Diabetes Mellitus;Nurses;Organelles;Outcome;oxidation;Participant;Persons;Phenotype;Positioning Attribute;Pre-Clinical Model;Prediabetes syndrome;prevent;Productivity;Protocols documentation;Public Health;recruit;Research;Research Institute;response;Risk Factors;Role;Scientist;Series;shift work;simulation;Skeletal Muscle;Sleep;Small Interfering RNA;Source;Standardization;System;Techniques;Testing;Training;Translational Research;United States National Institutes of Health;Work

PROJECT_TITLE: Impact of Shiftwork on Metabolic Flexibility and Skeletal Muscle Clocks

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative The IUSM Graduate Division has committed significant resources and focused effort in order to increase the diversity of our applicant pool and enrolled students. The central mission of IMSD at IUSM Training Program will be to provide graduate students with a holistic training experience that enriches their technical, operational and professional skills. The specific goals of the program include to increase the number of students that obtain independent fellowships, increase PhD completion rates, decrease time-to-degree, and provide transferable curricular content.

PI_NAMEs: HURLEY, THOMAS D. (contact);YEH, ELIZABETH S

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Biomedical Research;Indiana;medical schools;Training Programs;Universities

PROJECT_TITLE: IMSD at Indiana University School of Medicine through Inclusive Biomedical Research Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Brain Disorders;Fragile X Syndrome;Genetics;Human Genome;Huntington's Disease;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: Public health relevance Genome instability is a hallmark a wide range of disease-states including cancer and neurologic conditions. Over two dozen neurodegenerative, musculoskeletal, and neurological disorders are caused by triplet repeat expansions, the mechanisms of which are not well understood. The studies proposed here will provide a deeper understanding of the crosstalk between DNA repair pathways and the impact of this crosstalk on repeat expansion and will also yield novel mechanistic insights into the function of enzymes that modulate repeat expansion, and will thus have wide-ranging biomedical implications.

PI_NAMEs: PLUCIENNIK, ANNA  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Age of Onset;Animal Disease Models;Attenuated;Biochemical;CAG repeat;causal variant;Cell Extracts;Cell model;Cell Physiology;CGG repeat expansion;Chromosomal Rearrangement;Closure by clamp;cofactor;Data;Deoxyribonucleases;Dependence;Disease;Dissection;DNA;DNA Damage;DNA Interstrand Cross-Link Repair;DNA Interstrand Crosslinking;DNA Repair;DNA Repair Pathway;DNA replication fork;DNA Sequence;DNA Structure;Elements;environmental agent;Enzymes;Equilibrium;Evaluation;Excision;Fragile X Syndrome;Friedreich Ataxia;Gene Expression Regulation;gene repair;Genetic;Genetic Recombination;Genetic study;Genome;Genome Stability;genome wide association study;Genomic Instability;Human;human disease;Human Genome;Huntington Disease;insight;interest;Ionic Strengths;Knock-out;Length;Maintenance;Malignant Neoplasms;Mediating;Metabolism;Mismatch Repair;Mismatch Repair Gene Inactivation;MLH1 gene;Molecular;Molecular Conformation;MSH2 gene;MSH3 gene;Musculoskeletal Diseases;Mutation;Myotonic Dystrophy;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;novel;nuclease;Onset of illness;Pathway interactions;Patients;Physiological;Play;PMS1 gene;PMS2 gene;prevent;Prevention;Process;Production;Proliferating Cell Nuclear Antigen;protein protein interaction;protein purification;Proteins;Proteomics;public health relevance;repair function;repaired;Replication Error;response;Role;Sequence Homologs;Slide;structural determinants;Structure;System;Trinucleotide Repeats;Work

PROJECT_TITLE: Crosstalk between DNA repair pathways in repeat instability

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Patient Safety;Physical Rehabilitation;Rehabilitation

PHR: Older adults with Alzheimer’s Disease and related dementias are increasingly likely to be discharged to a skilled nursing facility after hospitalization for a serious injury or illness. Transitions from one health care setting to another are a precarious time for cognitively impaired patients who are at risk of inappropriate hospital readmissions and medication errors, among other potential adverse outcomes. By investigating the characteristics, health care utilization, and health outcomes of cognitively impaired patients who experience multiple transitions from home to hospital to a skilled nursing facility to home, we can design interventions that improve the quality of care and health outcomes for these patients.

PI_NAMEs: CARNAHAN, JENNIFER LYNN (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Accident and Emergency department;acute care;Admission activity;adverse outcome;Age;Aging;Alzheimer's disease patient;Alzheimer's disease related dementia;Ambulatory Care;Attention;Back;billing data;career development;Caregivers;Caring;Characteristics;Clinic Visits;Complex;Computerized Medical Record;Data;Data Set;Dementia;Development Plans;Diagnosis;Economics;Event;experience;follow-up;functional decline;Funding;Future;Gender;Goals;Health;Health and Retirement Study;health care service utilization;health care settings;Health Policy;Healthcare;high risk;Home;home based service;Home Care Services;hospital readmission;Hospitalization;Hospitals;Impaired cognition;improved;Income;Indiana;Individual;Injury;insight;Intervention;Intervention Trial;Interview;Length of Stay;Link;Measures;Medical;Medicare/Medicaid;Medication Errors;Modeling;older adult;Outcome;Outpatients;Patient Discharge;patient home care;Patient Readmission;Patient-Focused Outcomes;Patients;Persons;Physical Function;Population Heterogeneity;posthospitalization care;prevent;primary outcome;Quality of Care;readmission risk;Rehabilitation therapy;Research;Research Methodology;Research Personnel;Risk;Scholarship;secondary outcome;Severities;Skilled Nursing Facilities;social;Social isolation;support network;therapy design;Time;Training;United States Centers for Medicare and Medicaid Services;Visit;Work

PROJECT_TITLE: The Coming Home After Rehabilitation and Transition from a Skilled nursing facility with Dementia Study (The CHARTS-D Study)

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Host innate immune response plays a crucial role in combating infections. This study will elucidate new antibacterial functions of two interferon stimulated genes, OAS1 and OASL. The discovery of OAS proteins' role in antibacterial host defense will have a broader implication for human infectious diseases and the development of new treatments against antibiotic-resistant bacterial infections. In addition, our findings may provide a link between OAS1 polymorphisms and human infectious and autoimmune diseases.

PI_NAMEs: RATHINAM, VIJAY ;SARKAR, SAUMENDRA N (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: 2019-nCoV;Address;Anti-Bacterial Agents;antimicrobial;Autoimmune Diseases;Bacteria;Bacterial Antibiotic Resistance;Bacterial Genes;Bacterial Infections;Binding Proteins;Biochemical;Biological;cell type;Cells;Communicable Diseases;cytokine;Data;design;Development;experimental study;Family;Francisella tularensis;Gene Family;Genes;Genetic Polymorphism;genome wide association study;Goals;guanylate;Homologous Gene;Host Defense;Human;Immune;Impairment;In Vitro;in vivo;Infection;Inflammatory;innate immune function;Innate Immune Response;innovation;insight;Interferon Type I;Interferons;IRF1 gene;Knock-in Mouse;Knowledge;Length;Ligase;Link;Listeria monocytogenes;Macrophage;Mediating;Mediator;member;Modeling;Molecular;mouse model;Mus;Natural Immunity;novel therapeutic intervention;oligoadenylate;Orthologous Gene;Play;Population;Predisposition;Production;Protein Family;Protein Isoforms;Protein Synthesis Inhibition;Proteins;Publishing;Regulation;response;Ribonucleases;RNA Degradation;Role;Signal Transduction;Testing;transcription factor;Transferase;Translations;Up-Regulation;Viral;Viral Physiology;Virus Diseases

PROJECT_TITLE: New roles of IFN-inducible OAS proteins in innate immune defense against bacterial infections


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Valley Fever

ORG_CITY: FLAGSTAFF

ORG_DEPT: MISCELLANEOUS

ORG_NAME: NORTHERN ARIZONA UNIVERSITY

ORG_STATE: AZ

PHR: The incidence of coccidioidomycosis (Valley Fever), caused by the highly infectious soil fungi Coccidioides posadasii and C. immitis, has been rapidly growing for decades with current statistics estimating 150,000 new cases annually in the United States. Serological diagnosis is the most common method, typically detecting the presence of antibodies (four tests on the market) or antigens (one test on the market), and both types of diagnostic tests are based on intellectual property owned by companies and thus no commercial provider of antigens or antibodies is available. Advanced diagnostic development approaches can help improve our ability to detect and diagnose infection and we propose to use both well-validated methodologies and innovative novel approaches to improve Valley Fever diagnostics.

PI_NAMEs: BARKER, BRIDGET MARIE (contact);CATANZARO, DONALD G;WANG, JOSEPH

PROJECT_TERMS: accurate diagnosis;Affinity;Animals;Anti-Bacterial Agents;anti-fungal agents;Antibodies;antibody test;antigen diagnostic;antigen test;Antigens;Area;bacterial community;bioelectronics;Bioinformatics;Biological;Biological Assay;Biological Markers;biomarker identification;biomarker validation;Biosensor;Blood;candidate selection;Centers for Disease Control and Prevention (U.S.);Central America;Clinical;Clinical Trials;Coccidioides;Coccidioides immitis;Coccidioides posadasii;Coccidioidomycosis;community acquired pneumonia;cost;Coupled;Data;Data Analyses;Dependence;desert fever;design;Detection;detection limit;Development;Diagnosis;Diagnostic;diagnostic assay;diagnostic development;Diagnostic tests;diagnostic tool;Disease;effective therapy;Engineering;Escherichia coli;Evaluation;experimental study;Filtration;fungus;Future;Gene Proteins;Genes;genomic data;Genomics;Goals;Harvest;Health Care Costs;Human;Hydrocortisone;Imagery;Immune response;imprint;improved;in silico;In Vitro;in vivo;Incidence;Industry;Infection;innovation;Intellectual Property;interdisciplinary approach;Laboratories;Length of Stay;manufacture;Marketing;Methodology;Methods;model organism;Molecular;Mus;Mycoses;novel;novel diagnostics;novel strategies;Outcome Study;pathogenic fungus;Patient-Focused Outcomes;Patients;Performance;peripheral blood;Phase;Polymers;Process;Protein Secretion;Proteins;Provider;radiological imaging;rapid diagnosis;Rapid diagnostics;rational design;reagent testing;Recombinant Proteins;Recombinants;Reporting;Reproducibility;Research;Resource-limited setting;Sampling;screening;sensor;Serodiagnoses;Serum;Soil;South America;Southwestern United States;Specificity;statistics;Structure of parenchyma of lung;Symptoms;synthetic antibodies;synthetic biology;System;Techniques;Testing;time use;Transcript;transcriptome sequencing;United States;Up-Regulation;Validation

PROJECT_TITLE: Rational design of a novel rapid diagnostic tool for coccidioidomycosis

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]