NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Opioids;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Alcohol use disorder (AUD) affects approximately 14.1 million people in the United States. Despite the prevalence of this disorder, we lack a thorough understanding of its underlying neurobiological mechanisms. Here, we propose to use a multi-faceted mechanistic investigation to being to unravel the role of extended amygdala neuromodulatory action in AUD.

PI_NAMEs: KASH, THOMAS L.;MCELLIGOTT, ZOE ANASTASIA (contact)

PROJECT_TERMS: activity marker;Address;Adrenergic Receptor;Affect;Affective;Agonist;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol response;alcohol use disorder;Alcohols;Amygdaloid structure;Anabolism;Anatomy;anxiety-like behavior;Area;Behavior;Behavior assessment;Biosensor;Brain;Brain imaging;Brain region;Chronic;Collaborations;Consumption;Coping Behavior;Coupled;CRISPR/Cas technology;Disease;Dopamine;Dynorphins;Electrophysiology (science);Evaluation;Exposure to;Female;Fiber;Functional Magnetic Resonance Imaging;Funding;gamma-Aminobutyric Acid;genetic manipulation;Glutamates;Goals;Grant;Heavy Drinking;in vivo;Individual;individual variation;insight;Investigation;kappa opioid receptors;Knock-out;Laboratory Finding;male;Modality;Modeling;Molecular;multidrug abuse;Mus;negative affect;neurobiological mechanism;Neurons;neuroregulation;nonhuman primate;noradrenergic;Norepinephrine;norepinephrine system;novel;Outcome;Outcome Measure;Output;Pathway Analysis;Persons;pharmacologic;Photometry;Physiology;Play;Prevalence;Property;Receptor Signaling;Regulation;Research Project Grants;response;Role;Sex Differences;Signal Pathway;Signal Transduction;Slice;Stress;Stress and Coping;Structure;Structure of terminal stria nuclei of preoptic region;System;Testing;United States;Ventral Tegmental Area;Withdrawal;Work

PROJECT_TITLE: 5/8 INIA Stress and Chronic Alcohol Interactions: Probing brain circuits that regulate alcohol stress interactions


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Congenital Structural Anomalies;Infectious Diseases;Microbiome;Neurosciences;Pediatric;Rare Diseases;Spina Bifida;Urologic Diseases

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Urinary tract infections (UTIs), a frequent problem in children with spina bifida, are notoriously difficult to diagnose in this population. The goal of this research is to first develop a method to identify which children with spina bifida are at high risk for a UTI, and then develop a more accurate way to diagnose UTIs in this population. The results of this research will lead to more appropriate antibiotic use, thus tempering the rising rate of UTIs with antibiotic-resistant organisms seen in children with spina bifida.

PI_NAMEs: FORSTER, CATHERINE S (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: 16S ribosomal RNA sequencing;accurate diagnosis;Address;Adult;Algorithms;anti-microbial peptide;Antibiotic Resistance;Antibiotic Therapy;Antibiotic-resistant organism;Antibiotics;Area;Award;Bacteriuria;Bioinformatics;Biological Markers;biomarker identification;Bladder;Bladder Diseases;Bladder Injury;candidate marker;career;career development;Caring;Cessation of life;Characteristics;Child;Child Health;Childhood;Chronic;Clinical;Clinical Research;clinical training;cohort;Complement;cytokine;Data;Dedications;design;Development;Development Plans;Diagnosis;diagnostic algorithm;Diagnostic Procedure;Diagnostic tests;Environment;Escherichia coli;Evaluation;evidence base;experience;Funding;Genetic;Genetic Models;Goals;Health;Health Care Costs;High Prevalence;high risk;high risk population;Hospitals;Immune response;improved;infection risk;Inflammation;innovation;Institution;International;Knowledge;LCN2 gene;Literature;Measures;Medicine;Mentors;Mentorship;Methods;microbial;microbiome;Mission;Modeling;mouse genetics;mouse model;multi-drug resistant pathogen;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Neurogenic Bladder;nonpathogenic Escherichia coli;novel;Operative Surgical Procedures;Organism;Outcome;Patients;Pediatric cohort;Pediatric Hospitals;pediatric patients;pediatrician;Persons;Population;preservation;Probability;prospective;Protocols documentation;Publishing;recruit;Renal function;Reporting;Research;Research Personnel;Research Training;Resistance;Resources;Risk;Sampling;skills;Spinal Dysraphism;Study models;Symptoms;Testing;Training;Translating;Universities;urinary;Urinary tract;Urinary tract infection;Urine;Urodynamics;urologic;Uropathogenic E. coli;Urothelium;Work

PROJECT_TITLE: The association between the urine microbiome, the host immune response and urinary symptoms in children with spina bifida

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Estrogen;Liver Disease;Neurosciences;Women's Health Research

ORG_CITY: FORT WORTH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE The sex differences related to the physiological mechanisms that cause fluid retention associated with cirrhosis are unknown. Animal models of cirrhosis will be used to determine the physiological and cellular mechanisms that produce sex differences in vasopressin release and fluid retention associated and differences in gene expression in vasopressin neurons among males and females using spatial transcriptomics to bridge this gap in our understanding and eventually to identify new therapeutic targets.

PI_NAMEs: NGUYEN, DIANNA HUYEN-TRAM (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Acute;Animal Model;antagonist;Arginine;bile duct;Body Fluids;Body Water;Brain-Derived Neurotrophic Factor;Cardiovascular system;Central Nervous System;Chronic Disease;Circulation;Cirrhosis;Clinical;clinical practice;Congestive Heart Failure;cost;Data;defined contribution;Development;dilutional hyponatremia;Electrolyte Disorder;ESR1 gene;Estrogen Receptor 2;Estrogen Receptors;experimental study;Female;Fluid Balance;Fostering;Fulvestrant;Functional disorder;Gene Expression;Goals;GPER gene;Heart failure;Hormones;Hospitals;Hyponatremia;Hypothalamic structure;Infusion procedures;Injury;insight;Kidney;Knowledge;Ligation;Liquid substance;Literature;Liver Cirrhosis;Liver Failure;magnocellular;male;Modeling;mortality;Neurons;new therapeutic target;novel;novel therapeutic intervention;older patient;Osmoregulation;Outcome;Oxytocin;paraventricular nucleus;Pathogenesis;patient population;Patients;Peripheral;Physiological;Posterior Pituitary Hormones;Prognosis;Rattus;Regulation;Research;Resources;Risk Factors;Role;sex;Sex Differences;sexual dimorphism;Signal Transduction;Sodium;Spinal cord injury;Subarachnoid Hemorrhage;supraoptic nucleus;Surrogate Markers;System;Testing;Therapeutic;transcriptomics;Trauma;United States;V2 Receptors;Vasopressins;Water

PROJECT_TITLE: Role of Estrogen Receptors and Neurohypophyseal Gene Expression in Vasopressin Release in a Model of Dilutional Hyponatremia


ADMINISTERING_IC: MH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: NARRATIVE Preexposure prophylaxis (PrEP) is an effective tool to reduce new HIV infections, however, it is underutilized, especially in the South and among heavily impacted groups, such as racial and ethnic minorities. This application focuses on the development and evaluation of a multifaceted strategy to improve PrEP implementation among individuals incarcerated at the Dallas County Jail. By using data from electronic health records and patients’ health histories to identify candidates for PrEP, engaging them in informed decision- making about PrEP, and providing navigation to PrEP care upon community re-entry, this project has potential to improve PrEP use and reduce HIV infections in this vulnerable population.

PI_NAMEs: KRAKOWER, DOUGLAS SCOTT;NIJHAWAN, ANK ELISABETH (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: acquired factor;Administrator;Affect;AIDS prevention;Area;Back;Black Populations;candidate identification;Caring;Clinical;clinical care;Collaborations;Communities;community organizations;community reentry;County;Criminal Justice;Data;Data Reporting;Decision Making;Development;Diagnosis;effectiveness/implementation hybrid;effectiveness/implementation study;electronic health data;Electronic Health Record;Epidemic;ethnic minority;Evaluation;evidence base;experience;Exploration, Preparation, Implementation, and Sustainment;Feedback;Future;Goals;Health;Health system;high risk;HIV;HIV Infections;HIV/STD;Hospitals;Human immunodeficiency virus test;implementation evaluation;implementation outcomes;implementation process;implementation science;implementation strategy;Imprisonment;improved;Incidence;Individual;innovation;Interruption;Intervention;Interview;Jail;Latinx population;Link;Location;Measures;medically underserved;Methods;Minority Groups;Modeling;novel strategies;Outcome;patient oriented;Patients;Penetration;Persons;Population;Populations at Risk;pre-exposure prophylaxis;Predictive Analytics;Prevention;Primary Care;Prisons;Process;programs;Provider;Public Health;Qualitative Research;racial minority;Recording of previous events;Research Design;Resources;response;Risk Factors;Role;Rural;safety net;Series;shared decision making;System;Testing;Time;tool;United States;virtual;Vulnerable Populations;Work

PROJECT_TITLE: Hybrid implementation-effectiveness study to optimize HIV testing and PrEP in a southern jail (HOTSPOT)

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Data Science;Digestive Diseases;Genetics;Human Genome;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Ovarian Cancer;Precision Medicine;Rare Diseases;Stomach Cancer;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Project Narrative I will study how the interplay between clonal evolution and phenotypic plasticity impacts patient response to therapy and metastasis in cancer. I propose a novel causal inference statistical framework designed to identify causal determinants of drug resistance and metastasis from multi-omic single cell datasets in lung, ovarian and gastric cancer.

PI_NAMEs: SALEHI, SOHRAB  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Affect;anti-cancer research;Biological Assay;cancer cell;cancer type;career;causal model;Cell Communication;Cells;chemotherapy;Clinical;Clonal Evolution;Computer software;computerized tools;Computing Methodologies;Data;Data Set;Death Rate;design;Detection;Development;Disease;Disease Resistance;Disseminated Malignant Neoplasm;driver mutation;Drug resistance;drug resistance development;Ensure;Epigenetic Process;epigenome;Event;experimental study;Gastric Adenocarcinoma;Gene Expression;Genetic;Genome;genome sequencing;Genomics;Goals;Graph;Hand;high dimensionality;Human;improved;Intervention;Invaded;Lead;Learning;Link;Literature;lymph nodes;Machine Learning;machine learning method;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;malignant stomach neoplasm;Measures;Mentors;Mentorship;Metastatic Neoplasm to the Lung;Methods;Modality;Modeling;Morbidity - disease rate;multimodal data;multimodality;Multiomic Data;multiple omics;Neoplasm Metastasis;neoplastic cell;Normal tissue morphology;novel;Organ;Outcome;patient derived xenograft model;patient response;Patients;personalized medicine;pharmacologic;Phase;Phenotype;Population;Process;programs;Property;Recurrence;Resistance;Sampling;Serous;Shapes;single cell ATAC-seq;single-cell RNA sequencing;Site;small cell lung carcinoma;Somatic Mutation;Statistical Models;statistics;Structure;Techniques;tenure track;Testing;Therapeutic;therapy resistant;Training Programs;transcriptome;translational impact;translational study;Treatment Failure;treatment response;Tropism;tumor;tumor heterogeneity;tumor microenvironment;tumor progression

PROJECT_TITLE: Causal determinants of drug resistance and metastasis in cancer with multimodal single cell data


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative The goals of our research are to 1) elucidate the mechanistic link between skin microbiota and local immune dysregulation in rosacea skin and 2) elucidate potential systemic immune dysregulation in rosacea patients. Unlike prior studies, we aim to employ multi-omics data integration to 1) explain the complex relationship of the microbial environment and the host immune response in the skin, and 2) characterize the systemic immune dysregulation that can explain the systemic disease burden in rosacea patients. We anticipate that our findings will lead to the development of novel preventative and therapeutic targets and shift the way we study and manage rosacea toward early detection and prevention of systemic co-morbidities.

PI_NAMEs: MCGEE, JEAN SUH (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Advanced Development;Affect;Atherosclerosis;Bioinformatics;Biological Assay;Biological Response Modifiers;Biometry;Blood;Blood Vessels;burden of illness;cardiovascular risk factor;career;career development;cathelicidin;cathelicidin antimicrobial peptide;Cells;Circulation;Clinical Trials;commensal microbes;Communication;comorbidity;Complex;Computational Biology;Core Facility;Country;cytokine;Data;data integration;Development;Disease;dysbiosis;Early Diagnosis;Educational workshop;Environment;Epidemiology;Epithelium;Etiology;Exclusion;experience;Expression Profiling;Genetic Transcription;Goals;Grant;Health;Homeostasis;host microbiota;Human Subject Research;IL17 gene;Immune;immune activation;Immune response;improved;Inflammatory;Inflammatory Bowel Diseases;Innate Immune Response;Innate Immune System;insight;Institution;interleukin-22;Investigation;Israel;Kininogenase;Link;Mediating;Medical center;medical schools;Mentors;metagenomic sequencing;Microbe;microbial;microbiome;microbiota;Molecular;multidisciplinary;Multiomic Data;multiple omics;new therapeutic target;novel;Outcome;Pathogenesis;Pathway interactions;Patients;Peptides;personalized strategies;Persons;Physicians;Prevention;Principal Investigator;programs;protein expression;Proteome;Proteomics;Protocols documentation;Psoriasis;Public Health Schools;recruit;Regulator Genes;Research;research and development;response;Role;Rosacea;rRNA Genes;Scientist;Serine Protease;Serum;Shotguns;Signal Pathway;Signal Transduction;Skin;skin disorder;skin microbiome;skin microbiota;Stimulus;Systemic disease;Teaching Hospitals;Testing;Therapeutic;therapeutic target;TLR1 gene;TLR2 gene;TNF gene;Training;Transcriptional Activation;transcriptome;transcriptome sequencing;transcriptomics;United States;Whole Blood;Writing

PROJECT_TITLE: Multi-omic Studies of Local and Systemic Immune Dysregulation in Rosacea

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Sleep Research

ORG_CITY: CHICAGO

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: PROJECT NARRATIVE This project will provide recommendations to health care providers, as well as adolescents and their parents to improve efficacy of circadian-based treatment strategies aimed to help youngsters fall asleep early, increase school-night sleep duration, and improve morning alertness. Enhancing these outcomes will likely improve learning capacity and problem-solving, as well as reduce the risk of depressed mood, obesity, automobile accidents, alcohol or drug use, and other risk-taking behavior.

PI_NAMEs: CROWLEY MCWILLIAM, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: actigraphy;Adolescence;Adolescent;Adult;age group;aged;Alcohol consumption;Alcohols;alertness;Attenuated;automobile accident;awake;Beds;Behavior;Behavioral;Characteristics;Child;Chronic;circadian;Circadian desynchrony;circadian pacemaker;Circadian Rhythms;cognitive performance;conduct problem;cost effective;Darkness;Data;Depressed mood;Dose;Drowsiness;Drug usage;Effectiveness;Exposure to;falls;Feeling suicidal;Goals;Health Personnel;Household;Impairment;improved;Laboratories;Learning;Left;Light;Lighting;Measures;Melatonin;Moods;Nicotine;Obesity;Outcome;Outcome Measure;Parents;Participant;Performance;Phase;Phase response curves;Phototherapy;Pilot Projects;prevent;Problem Solving;Protocols documentation;Puberty;Randomized;Recommendation;Regimen;response;Risk;Risk Reduction;Risk Taking;Satiation;Schedule;Schools;secondary outcome;Side;Sleep;sleep behavior;sleep onset;substance use;sunglasses;System;Teenagers;Testing;Time;treatment guidelines;treatment strategy;Work;Wrist;Youth

PROJECT_TITLE: Adolescent circadian misalignment: Mechanistic studies of sleep and light

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Fluorescent proteins are broadly used reporters of gene expression, protein localization, and cellular activity in health and disease. However, the brightness of fluorescent proteins and biosensors decreases with prolonged illumination, limiting their utility for long-term imaging. The authors of this proposal propose extending the duration of biological imaging by developing fluorescent proteins and biosensors with improved photostability.

PI_NAMEs: ST-PIERRE, FRANCOIS  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Address;Adopted;Agar;Aging;Attention;Benchmarking;Biological;Biological Assay;Biomedical Research;Biophysics;Biosensor;Bulla;Calcium;Cell Cycle;Cell Death;Cell Physiology;Cell Shape;cell type;Cells;cellular imaging;chromophore;cofactor;college;Color;Coupling;Cytometry;Dedications;design;Detection;Development;Disease;Electrophysiology (science);Embryo;Engineering;Equipment;experimental study;Flow Cytometry;Fluorescence;Fluorescence-Activated Cell Sorting;Fluorescent Probes;fluorophore;Functional disorder;Gene Expression;Gene Proteins;Genetic Engineering;Health;high throughput screening;Image;Imaging Device;imaging modality;imaging probe;improved;Individual;interest;invention;Jellyfish;Label;Laboratories;Lasers;Learning;Light;Lighting;Mammalian Cell;Marine Invertebrates;Medicine;Membrane;metagenome;Metagenomics;Methods;Microscopy;millisecond;Mining;Modeling;monomer;Morphology;Mutagenesis;neuroimaging;Neurons;new technology;novel;Nuclear;nucleic acid localization;Optics;Pattern;Photobleaching;Photons;Procedures;Productivity;Property;Protein Engineering;Proteins;Protocols documentation;Rapid screening;Reagent;Recovery;red fluorescent protein;Reporter;Reporter Genes;Reporting;Research Proposals;Resolution;Resource Sharing;Sampling;Science;screening;Signal Transduction;single molecule;Site-Directed Mutagenesis;Specificity;Structure;Syncope;System;Techniques;Technology;temporal measurement;Tissue imaging;transcriptome;transcriptomics;two-photon;Variant;voltage

PROJECT_TITLE: Engineering photostable fluorescent proteins and biosensors using transcriptomic mining and massive-throughput single-cell screening

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Mental Health;Mental Illness;Pediatric

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: Narrative The National Institute of Mental Health has described a critical shortage of child and adolescent psychiatrists who pursue research as a major part of their career. We are determined to improve the yield of researchers for our field by developing the Research Education in Child and Adolescent Psychiatry (RE-CAP) research track within the largest child and adolescent psychiatry residency program in the United States, while also enriching neuroscience and research education for the full training program.

PI_NAMEs: FITZGERALD, KATE DIMOND;VEENSTRA-VANDERWEELE, JEREMY  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Academy;Address;Adolescent;Adolescent Psychiatry;Area;bench to bedside;career;Child;Child Psychiatry;Clinic;Clinical;Clinical Research;clinical training;cohort;Communities;Country;developmental neurobiology;Doctor of Philosophy;Education Projects;education research;Eligibility Determination;Epidemiology;experience;Exposure to;Feeds;Fellowship;flexibility;Flowers;Fostering;Funding;Genetic;Goals;Grant;Growth;Hospitals;improved;Institution;interest;K-Series Research Career Programs;Lesbian Gay Bisexual Transgender Queer;Link;Longitudinal cohort;medical schools;Medicine;Mentors;Mentorship;National Institute of Mental Health;Neurosciences;New York;Pathway interactions;personalized approach;Physicians;Post Graduate Year;Postdoctoral Fellow;Presbyterian Church;programs;Psychiatrist;Psychiatry;Publishing;recruit;Research;Research Personnel;Research Training;Residencies;Scientist;Structure;success;Time;Training;Training Programs;Translating;translational pipeline;Translational Research;Underrepresented Minority;United States;Universities;Woman;Youth

PROJECT_TITLE: Research Education in Child and Adolescent Psychiatry Residency


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: SURGERY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Narrative  Neonates with congenital cardiac diseases undergoing surgery requiring cardiopulmonary bypass using deep hypothermic circulatory arrest (DHCA) are at high risk for impaired neurodevelopmental progression due to time-related ischemia and exposure to toxic levels of brain metabolites. We will use 1H magnetic resonance spectroscopy to determine the real time metabolic changes occurring in the brain during DHCA and, importantly, during the alternative clinical strategy of antegrade cerebral perfusion (ACP) that provides oxygenated blood to the brain. The proposed studies will document continuous time-related changes in brain metabolites and correlate altered levels of these metabolites with alterations in cognitive development following DHCA and ACP bypass procedures.

PI_NAMEs: HANLEY, FRANK  (contact);SPIELMAN, DANIEL M

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Affect;Anatomy;Animals;Benchmarking;Birth;Blood;Blood specimen;Brain;Brain imaging;Brain Injuries;brain metabolism;Bypass;Cardiac Surgery procedures;Cardiopulmonary Bypass;cell injury;Cerebral cortex;Cerebrum;Clinical;clinical practice;cognitive development;cognitive testing;Comparative Study;congenital heart abnormality;Data;design;Diffusion Magnetic Resonance Imaging;Energy Metabolism;Exposure to;Glucose;heart defect;high risk;Histologic;insight;Ischemia;Kidney;Learning;Length;Life;Liver;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measurement;Measures;Memory;Metabolic;Metabolic Marker;Metabolic stress;Methodology;Modeling;natural hypothermia;neonate;Nervous System Trauma;Neurocognitive;Neurocognitive Deficit;Neurodevelopmental Impairment;Operative Surgical Procedures;Outcome;Patients;Perfusion;Phase;porcine model;preclinical study;predictive marker;preservation;prevent;Procedures;Protons;Pump;Recovery;Risk;Safety;success;Temperature;Time;time use;Tissue Harvesting;Tissues;United States

PROJECT_TITLE: Neurometabolic Outcomes of Different Cardiopulmonary Bypass Strategies

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Asthma;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Effects of Indoor Air Pollution;Immunization;Infectious Diseases;Lung;Pediatric;Prevention;Vaccine Related

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative This project will examine how asthma and its treatment with steroids affects the antibody response to COVID-19 infection and vaccination. We will measure antibody levels in the blood as well as from the surface of the nose and lungs. The information obtained by this study will be helpful in developing better vaccines to prevent COVID-19 infection and whether children with asthma are at higher risk for reduced antibody responses and highlight the importance of treatment with anti-COVID medicines when they are exposed to the virus at home or school.

PI_NAMEs: SUN, JIE ;TEAGUE, WILLIAM GERALD (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: 2019-nCoV;adaptive immune response;adaptive immunity;Adolescent;Adrenal Cortex Hormones;Affect;airway inflammation;Allergens;Antibodies;Antibody Response;Asthma;Attenuated;B-Lymphocytes;Biological Markers;Blood;booster vaccine;Bronchoalveolar Lavage;Bronchoscopy;Child;Childhood Asthma;co-infection;COVID-19;COVID-19 complications;COVID-19 prevention;COVID-19 vaccination;cytokine;Development;Dose;experience;Exposure to;Goals;high risk;Home;Hospitalization;Hospitalized Child;Immune;Immunization;Immunologist;Infection;Inflammation;Investigation;K-18 conjugate;Knowledge;Linear Models;Liquid substance;Lung;Lung Lavage Fluid;Measures;Mediating;Medicine;Modeling;Morbidity - disease rate;mortality;mouse model;Mucosal Immune Responses;Mucosal Immunity;Mucous Membrane;Mus;Nasal Lavage Fluid;neutralizing antibody;Nose;novel;pandemic disease;pathogenic virus;Pattern;Population;Populations at Risk;prevent;Pyroglyphidae;receptor binding;Reporting;Research Personnel;Respiration Disorders;respiratory;Respiratory Mucosa;respiratory virus;response;Risk;RNA vaccination;RNA vaccine;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 variant;Schools;Seasons;Steroids;Surface;surveillance study;T cell response;T-Lymphocyte;Transgenic Mice;Transgenic Organisms;Vaccination;vaccine immunogenicity;vaccine response;Vaccines;Variant;variants of concern;Viral;Viral Respiratory Tract Infection;Virus;Wheezing

PROJECT_TITLE: Determinants of Convalescent and Vaccine-induced Mucosal Specific Immunity to SARS-CoV-2 and Variants of Concern in Children with Asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Neurosciences;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The most common and most aggressive adult primary brain tumor is glioblastoma (GBM). In this study, we seek to develop tumor-derived cell-free DNA present in the circulation as a non-invasive biomarker to diagnose GBM and detect recurrent disease. The non-invasive assessment of GBM has the potential to directly affect patient care by enabling the optimization of clinical management prior to or instead of risk-associated invasive diagnostic procedures.

PI_NAMEs: UNDERHILL, HUNTER REEVE (contact)

PROGRAM_OFFICER_NAME: GANGULY, ANIRUDDHA

PROJECT_TERMS: Adult;Affect;Animal Model;Apoptosis;Appearance;Attenuated;Biological Markers;Brain;Brain Neoplasms;Catalogs;Cell Fraction;cell free DNA;Cells;Central Nervous System;Circulation;Clinical;Clinical Management;Custom;Data;design;Detection;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Procedure;Disease;DNA;DNA Markers;Excision;Frequencies;Gene Frequency;Genes;Genetic Heterogeneity;genetic variant;Genetic Variation;Genotype;Glioblastoma;Glioma;Goals;Histologic;Human;Image;improved;Knowledge;Length;Lesion;Malignant - descriptor;Malignant Neoplasms;Methods;Modeling;Molecular Profiling;Monitor;Neoplasm Metastasis;Neurologic Deficit;Newly Diagnosed;next generation sequencing;Noise;Operative Surgical Procedures;Patient Care;Patients;Perfusion;personalized biomarkers;Plasma;Plasma Cells;Point Mutation;Positioning Attribute;Primary Brain Neoplasms;Procedures;profiles in patients;promoter;Radiation necrosis;Rattus;Recurrence;Recurrent disease;Risk;Sampling;Solid Neoplasm;Somatic Mutation;Source;Specificity;Stable Disease;stem-like cell;Stroke;success;Testing;Time;Tissue Sample;Translating;Translations;treatment effect;treatment response;tumor;tumor DNA;Tumor Tissue;Tumor-Derived;Variant;variant detection;Work;Xenograft procedure

PROJECT_TITLE: Circulating Cell-Free DNA as a Personalized Biomarker to Diagnose and Monitor Glioblastoma

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prevention;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE We propose to conduct a series of large-scale genetic association studies to identify genetic risk factors for mammographic density and breast cancer. The proposed research will highlight underlying biological mechanisms and identify novel targets for breast cancer risk prediction and prevention.

PI_NAMEs: LINDSTROEM, SARA  (contact)

PROGRAM_OFFICER_NAME: NELSON, STEFANIE A

PROJECT_TERMS: Adipose tissue;Age;Age at Menarche;Alcohol consumption;Area;biobank;Biological;Biological Markers;Body mass index;Breast Cancer Risk Factor;breast density;Breast Feeding;cancer risk;cancer subtypes;cell type;Collaborations;Data;density;Environmental Risk Factor;Epithelium;Estradiol;European ancestry;Fatty acid glycerol esters;First Births;follow-up;gene environment interaction;Gene Expression;Genes;Genetic;genetic architecture;genetic association;genetic predictors;genetic risk factor;genetic variant;genome wide association study;genome-wide;genomic locus;Germ Lines;Heritability;Heterogeneity;Hormones;instrument;Knowledge;Link;Malignant Breast Neoplasm;Mammary Gland Parenchyma;Mammographic Density;Mendelian randomization;menopausal hormone therapy;novel;Outcome;parity;Pathway interactions;Phenotype;Population;predictive modeling;Prevention;Prevention strategy;Proxy;Research;Resources;response;Risk Factors;risk prediction;Scanning;secondary analysis;Series;SHBG gene;Surrogate Endpoint;Testosterone;Tissue-Specific Gene Expression;Tissues;tool;transcriptome;Woman;Work

PROJECT_TITLE: Integration of genetic, gene expression and environmental data to inform biological basis of mammographic density

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Diabetes;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Tuberculosis (TB) disease causes chronic inflammation and requires at least 6-months of treatment. In this proposal, we will characterize the impact of TB on stress hyperglycemia and risk of diabetes mellitus after TB treatment ends. Our results will improve understanding of how inflammation and diabetes interact to impact both TB treatment and metabolic health outcomes for patients with TB disease.

PI_NAMEs: MAGEE, MATTHEW JAMES (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Address;adipokines;Adipose tissue;Anthropometry;Anti-Inflammatory Agents;Biological Markers;Biopsy;Caring;Cause of Death;Cessation of life;Chronic;Clinical;clinical care;cohort;Collaborations;Communicable Diseases;Country;Data;Diabetes Mellitus;diabetes risk;Diagnosis;Disease;Endocrinology;Enrollment;Epidemic;Epidemiology;euglycemia;Event;evidence base;fasting glucose;Future;Glucose;Glucose Intolerance;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;Health;high risk;Homeostasis;Human;Hyperglycemia;Hypertrophy;Immune;immune activation;Immunology;improved;Incidence;Individual;Infection;Inflammation;Inflammatory;Insulin;Insulin Resistance;Integration Host Factors;Intervention Studies;Lipids;low and middle-income countries;Lung Diseases;Measures;Metabolic;Metabolic Diseases;Metabolism;Modeling;mouse model;multidisciplinary;novel marker;Obesity;Operative Surgical Procedures;Outcome;Participant;participant enrollment;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Physiological;Plasma;prevent;prospective;Public Health;Pulmonary Tuberculosis;Recommendation;Regulation;Relapse;Reporting;Research;Research Personnel;Resolution;Retrospective Studies;Risk;Risk Reduction;Sputum;Stress;stress management;Subcutaneous Tissue;T-Cell Activation;theories;Time;tissue biomarkers;Tissues;Trauma;treatment guidelines;Treatment outcome;treatment risk;Tuberculosis;Tuberculosis diagnosis;tuberculosis treatment;Uncertainty;United States National Institutes of Health;Work

PROJECT_TITLE: Immunometabolic impact of stress hyperglycemia on tuberculosis treatment outcomes and risk of diabetes mellitus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-A(02)M]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_CITY: WALTHAM

ORG_DEPT: BIOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative Changes in neurotransmitter identity represent a novel and potent form of homeostatic plasticity that exists in parallel to the multitude of synaptic strength-based plasticity mechanisms used to maintain the balance of activity within circuits. We have found that the set-point of adult sleep in Drosophila is determined by cells that exhibit transmitter plasticity. In this proposal we will uncover the basic mechanisms of this understudied form of plasticity and determine its role in setting the sleep homeostat.

PI_NAMEs: GRIFFITH, LESLIE C (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TITLE: Neurotransmitter Plasticity and Regulation of Behavior

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Rehabilitation;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: RELEVANCE The proposed study seeks to quantify the early age-related changes on brain MRI after unilateral ischemic stroke and how they relate to post-stroke cognition. A more complete understanding of white matter microstructural properties as they relate to cognition early after stroke represents a crucial step towards identifying responsible mechanisms and designing targeted treatments to treat and/or prevent post-stroke cognitive impairment.

PI_NAMEs: INGO, CARSON J (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acceleration;Acute;acute stroke;Admission activity;Affect;Age;age related;age related changes;aged;Alzheimer's Disease;Alzheimer's disease related dementia;Anisotropy;Anterior;Atrophic;Axon;Beck depression inventory;Black race;Blood Glucose;Blood Pressure;Blood Vessels;Body mass index;brain magnetic resonance imaging;Chronic;Clinical;Cognition;Cognitive;cognitive function;cognitive recovery;cognitive testing;Contralateral;Corpus Callosum;Data;Dementia;demographics;design;Diffusion;Diffusion Magnetic Resonance Imaging;Family;Female;Fiber;follow-up;General Population;Geometry;health care disparity;health disparity populations;Heterogeneity;Image;Impaired cognition;Impairment;Individual;Infarction;Ischemic Stroke;Knowledge;Laboratories;Lesion;Lifelong disability;Lipids;Location;Magnetic Resonance Imaging;Measures;middle age;mild cognitive impairment;Modeling;Morphology;nerve injury;neural;neural repair;Neurobehavioral Manifestations;neuroimaging marker;Neurologic;new therapeutic target;Older Population;Outcome;Participant;Patient Admission;Patients;Pattern;Persons;Population;post stroke;post stroke cognitive impairment;predictive modeling;prevent;Prognosis;prognostic;prognostic value;prognostication;Property;Race;racial population;Recovery;Risk;Severities;sex;Smoking;Stroke;stroke cognitive outcome;stroke incidence;stroke outcome;stroke patient;stroke recovery;stroke risk;Structure;Subgroup;Testing;Therapeutic Intervention;Time;Tissues;treatment strategy;United States;United States National Institutes of Health;Vascular Cognitive Impairment;vascular risk factor;white matter;White Matter Hyperintensity;Woman;Work

PROJECT_TITLE: Post-stroke normal appearing white matter diffusion properties and cognitive trajectories across age

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Hyaluronan is a key component of organs and may play a role in wound healing; however, the role of hyaluronan in the failing heart is not known. By understanding the role hyaluronan plays in cardiac scar formation and chronic fibrosis, we can expose novel therapeutic approaches to optimize these adaptations and minimize disease risk. This project will employ several innovative ideas and techniques to study impact of hyaluronan on fibroblast function and ventricular remodeling.

PI_NAMEs: LITTLE, DANIELLE T (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Acute;Acute myocardial infarction;acute wound;Adenoviruses;Advocate;Atomic Force Microscopy;Biomechanics;Cardiac;Cardiac Myocytes;cell type;Cells;Chronic;Chronic Phase;Cicatrix;Collaborations;Collagen;Data;Deposition;Development;Disease;disorder risk;Echocardiography;Elements;Embryo;Enterobacteria phage P1 Cre recombinase;Environment;Enzymes;Event;Extracellular Matrix;Family;Fellowship;Fibroblasts;Fibrosis;Future;gain of function;Goals;HAS2 gene;Health;Heart;Heart failure;heart function;histological stains;Hour;Hyaluronan;Hyaluronidase;Immune;In Vitro;in vivo evaluation;Infarction;Inflammatory;innovation;insight;Intervention;Ischemia;Knowledge;Laboratory Research;Lipids;Literature;loss of function;Metabolism;Molecular Weight;Mus;Muscle Cells;Mutant Strains Mice;Myocardial Infarction;Myocardium;novel;novel therapeutic intervention;Organ;Pathology;Phase;Play;prevent;Process;Production;Proliferating;Proteins;Regulation;Research;Role;Rupture;Scientist;Shapes;Techniques;Therapeutic;Tissues;tool;Training;Translating;Ventricular;Ventricular Function;Ventricular Remodeling;wound healing

PROJECT_TITLE: Dynamic Role of Hyaluronan in Ventricular Remodeling


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Estrogen;Neurodegenerative;Neurosciences;Nutrition

PHR: Project Narrative This study will test whether supplementation of equol, a metabolite of soy isoflavone, will slow cognitive decline and the progression of arterial stiffness and white matter structure of the brain in older adults without dementia as an early phase trial. This trial aligns with an NIA strategic goal of developing interventions to address Alzheimer’s disease and age-related dementias.

PI_NAMEs: SEKIKAWA, AKIRA  (contact)

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: Academy;Address;Affect;age related;Age-associated memory impairment;aged;Alzheimer's Disease;Alzheimer's disease related dementia;American;Amyloid beta-42;Amyloid beta-Protein;arterial stiffness;Biological;Biological Markers;Blood;Brain;brain volume;Carotid Atherosclerotic Disease;cerebrovascular;Cerebrovascular Circulation;Cognition;Cognitive;cognitive benefits;cognitive function;Collagen;comparison control;Control Groups;cost;Cross-Sectional Studies;crosslink;daidzein;Data;Dementia;design;Diet;early phase trial;Elastases;Elderly;equol;Goals;gut microbiome;Health;Hypertension;imaging study;Impaired cognition;improved;Individual;inhibitor;Intervention;Investigation;Isoflavones;Japan;Japanese;Knowledge;Lead;Lesion;Link;Measures;Medicine;microbiome;middle age;mild cognitive impairment;Nutrient;Observational Study;older adult;Outcome;Participant;Pathology;phase III trial;Phenotype;Placebos;Plasma;pre-clinical;Precision Health;preclinical study;prevent;primary outcome;Property;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Risk Factors;Risk Reduction;Role;Sampling;secondary outcome;Serum;Signal Transduction;Site;Smooth Muscle Myocytes;soy;soy protein isolate;Structure;Subgroup;Supplementation;tau-1;Testing;Therapeutic;therapeutic target;Time;trend;trial design;Vascular calcification;Vascular Smooth Muscle;Venous;white matter;Woman

PROJECT_TITLE: Arterial Stiffness, Cognition, and Equol (ACE)


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Rehabilitation

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: The central goal of this proposal is to understand the neural systems subserving the decision to use the left or right hand – a simple choice that is central to our daily functions. Here we focus on parietal mechanisms of limb selection. The work may inform rehabilitation approaches for patients with neurological disorders including stroke and traumatic brain injuries in whom limb use is affected.

PI_NAMEs: MOOSHAGIAN, ERIC F (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Affect;Animals;arm;arm movement;Attention;Behavior;Bilateral;Biomechanics;Brain;Code;Communication;Contralateral;Corpus Callosum;daily functioning;Decision Making;Dimensions;Experimental Designs;Eye;Face;Fiber;Foundations;Future;Goals;Hand;Hand functions;Handedness;insight;Ipsilateral;Left;Lidocaine;Light;Limb structure;Macaca;Maps;Measures;Mediating;Mediation;Monkeys;Motion;Motor;motor behavior;motor control;Movement;neglect;Nervous System Disorder;neural;Neurons;nonhuman primate;Parietal;Parietal Lobe;Patients;Physiological;Physiology;Positioning Attribute;preference;Preparation;Rehabilitation therapy;Research;response;Role;Saccades;Signal Transduction;Stimulus;Stroke;System;Telephone;Testing;Time;Training;Traumatic Brain Injury;visual motor;Work

PROJECT_TITLE: Neural basis of limb selection in unimanual reaching

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: NARRATIVE Axons (the long cellular connections among nerve cells) typically fail to regrow when severed, leading to paralysis after spinal cord injury. We have discovered a series of compounds that promote the growth of axons in the brain and spinal cord. The goal of this proposal is to improve the properties of these compounds to generate candidate drugs that can be tested in clinical trials of injured patients.

PI_NAMEs: AL-ALI, HASSAN  (contact);BIXBY, JOHN L;LEMMON, VANCE P

PROGRAM_OFFICER_NAME: CYWIN, CHARLES L

PROJECT_TERMS: absorption;Address;Adult;analog;Animal Model;Animal Testing;Axon;axon growth;axon injury;axon regeneration;Biological Assay;Bladder;Brain;Breathing;Cells;Central Nervous System;central nervous system injury;Chemicals;Chemistry;Chronic;Clinical;clinical candidate;Clinical Trials;Complex;cost;Development;drug candidate;drug development;Drug Kinetics;Drug Targeting;Economic Burden;Effectiveness;Failure;Family;Generations;Goals;Growth;Health Insurance;Healthcare;Healthcare Systems;Heart;improved;In Vitro;in vivo;in vivo evaluation;Individual;inhibitor therapy;injured;Injury;Intellectual Property;International;Intestines;Investigation;kinase inhibitor;Lead;lead candidate;lead optimization;Legal patent;Machine Learning;Metabolism;Modeling;Motivation;Mus;Natural regeneration;neuron loss;Neurons;novel;novel therapeutic intervention;painful neuropathy;Paralysed;Patients;Persons;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Phenotype;Phosphotransferases;preclinical development;Property;Protocols documentation;psychologic;Rattus;Regenerative capacity;Reproducibility;Research;Risk;screening;Series;Sexual Dysfunction;small molecule;Source;Spinal Cord;Spinal cord injury;Structure-Activity Relationship;Synthesis Chemistry;Testing;Therapeutic;therapeutic candidate;Thinking;Toxic effect;Toxicology;translational potential;United States National Institutes of Health;Work

PROJECT_TITLE: Developing a kinase inhibitor drug to treat spinal cord injury


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Drug Abuse (NIDA only);Emergency Care;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Telehealth

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative The COVID-19 public health emergency exposed societal vulnerabilities and racial/ethnic health disparities in access and quality of healthcare for patients with a substance use disorder (SUD). This study will examine the effects of changes to addiction treatment practices on outcomes at the patient, organizational, and community levels, with a focus on Black/African American and Latinx clients. The findings from this study will inform public health responses to reduce health disparities in vulnerable communities.

PI_NAMEs: NEIGHBORS, CHARLES J (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: access disparities;addiction;African American;Ambulatory Care;Black race;Calendar;Caring;Characteristics;Client;Clinic;Clinical;clinical practice;Communities;community-level factor;Counseling;COVID-19;COVID-19 impact;Data;design;Disparity;Distal;Dose;Drug Screening;drug use screening;eHealth;Emergency department visit;ethnic health disparity;Ethnic Origin;flexibility;Gender;Government;group counseling;Group Meetings;health care disparity;health care quality;Health Personnel;Home;Hospitalization;improved;Individual;Latinx;Latinx population;Measures;Medicaid;Medical;medical specialties;Medication Management;Methadone;methadone treatment;Methods;Modeling;New York;novel therapeutic intervention;opioid use disorder;Outcome;Outpatients;Overdose;Patient Care;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Policies;programs;Provider;psychosocial;Public Health;public health emergency;Qualitative Methods;Quality of Care;Race;racial health disparity;Reduce health disparities;Registries;Relaxation;Research;Resources;response;screening;Self Administration;Shock;social;Social Distance;Substance Use Disorder;System;Technology;telehealth;Telemedicine;Testing;Time;treatment organization;Treatment outcome;treatment services;Variant;vulnerable community

PROJECT_TITLE: Addictions treatment organizational response to COVID-19: impact on disparities in quality of care

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Digestive Diseases;Genetics;Liver Disease;Neurosciences;Nutrition;Sleep Research

PHR: Project Narrative: A major function of the circadian system is to align feeding and metabolic cycles to optimize nutrient storage and utilization across the light/dark cycle, though how the clock senses changes in nutrient availability to maintain metabolic homeostasis throughout the day is not well-understood. The major goals of our proposed studies are (i) to dissect the mechanisms underlying the role of the clock at the level of liver and brain in maintaining energy constancy during fasting/sleep, and (ii) to dissect the molecular basis for nutrient sensing by the clock that underlies the physiologic adaptation to healthful calorie restriction. Results from the proposed studies will elucidate how the clock sustains the vital provision of energy to brain during sleep and how calorie restriction acts through the clock to improve health.

PI_NAMEs: BASS, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: Ablation;Acetylation;ARNTL gene;Behavioral;Bioenergetics;Body Temperature;Brain;Caloric Restriction;Cell Respiration;Cells;circadian;circadian pacemaker;Communication;CRISPR/Cas technology;Darkness;Deacetylase;Deacetylation;detection of nutrient;Diet;Disinhibition;Epigenetic Process;Exhibits;Fasting;feeding;gain of function;Genetic;genetic approach;genetic manipulation;Genetic Transcription;Goals;Health;Health Benefit;Hepatic;Homeostasis;Hypothalamic structure;improved;innovation;Knock-in Mouse;Lactobacillus brevis;Light;Link;Liver;loss of function;Maintenance;Mammals;Medial Dorsal Nucleus;Metabolic;Metabolic Pathway;Metabolism;mimetics;Mitochondria;Molecular;Mus;Mutant Strains Mice;NADH;NADH oxidase;neural circuit;Neurons;Neurosecretory Systems;Nicotinamide adenine dinucleotide;Nutrient;Nutrient availability;Output;Oxidation-Reduction;Pacemakers;Pathway interactions;Periodicity;Peripheral;Physiological Adaptation;Post-Translational Protein Processing;programs;Protocols documentation;Publishing;Reaction;Resistance;Respiration;response;Role;Signal Transduction;SIRT1 gene;Sleep;sleep regulation;Sleep Wake Cycle;suprachiasmatic nucleus;System;Testing;Thermogenesis;Tissues;tool;Water

PROJECT_TITLE: Circadian SCN-Liver Axis in the Neuroendocrine Response to Calorie Restriction

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative for R01 application by Hayakawa  Extracellular mitochondria transfer in gray and white matter for ameliorating sensorimotor and  cognitive deficits after stroke  Mitochondria are important for maintaining energy homeostasis in mammalian cells, but it is now increasingly recognized that mitochondria may be surprisingly release and transfer from cell to cell. Is it possible that this mitochondrial transfer may represent a novel non-autonomous mechanism to supply energy and promote neuron-oligodendrocyte-vascular recovery after stroke? Here, we propose that post-translational modification by O-GlcNAc amplifies extracellular mitochondrial functionality and efficient mitochondrial transfer that can accelerate the blood-brain barrier repair, remyelination and improve neuroplasticity. Therefore, these mechanisms should boost sensorimotor recovery and ameliorate post-stroke dementia after focal ischemia.

PI_NAMEs: HAYAKAWA, KAZUHIDE  (contact)

PROJECT_TERMS: Acceleration;Aging;Allografting;angiogenesis;Animals;Astrocytes;behavioral outcome;Blood - brain barrier anatomy;Blood Vessels;brain endothelial cell;Cell Survival;Cells;Central Nervous System;Cerebral endothelium;Cerebral Ischemia;Cognitive;Cognitive deficits;cognitive function;cognitive recovery;cognitive testing;Collaborations;Confocal Microscopy;CRISPR/Cas technology;Cyclic ADP-Ribose;Data;Dementia;deprivation;Electrophysiology (science);Elements;Endothelial Cells;Endothelium;Energy Supply;Etiology;experimental study;extracellular;Female;functional improvement;gain of function;Glucose;glycation;Golgi Apparatus;gray matter;Homeostasis;Human;improved;In Vitro;in vivo;in vivo imaging;Infarction;inhibitor;Integrins;Ischemia;Knowledge;Label;loss of function;male;Mammalian Cell;Maps;Mass Spectrum Analysis;Mediating;Metabolism;Methods;Mitochondria;Mitochondrial Proteins;Modification;Molecular;Mus;neural growth;neurogenesis;Neurologic;neurological recovery;Neuronal Plasticity;Neurons;neuroprotection;neurovascular;neutralizing antibody;novel;novel strategies;novel therapeutic intervention;oligodendrocyte progenitor;Oligodendroglia;Oligonucleotides;optical imaging;Outcome;Oxygen;PARK7 gene;Pathway interactions;Pattern;PECAM1 gene;pharmacologic;Plasmids;Play;post stroke;post stroke dementia;Post-Translational Protein Processing;potential biomarker;precursor cell;prevent;Process;Property;Proteins;Publishing;Rattus;Recombinants;Recovery;Recovery of Function;remyelination;repaired;response;Role;Sensorimotor functions;Signal Induction;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Site-Directed Mutagenesis;Small Interfering RNA;spatiotemporal;Specific qualifier value;Stroke;Testing;Therapeutic;Tissues;tool;trafficking;transcriptome;Western Blotting;white matter

PROJECT_TITLE: Extracellular Mitochondria Transfer in Gray and White Matter for Ameliorating Sensorimotor and Cognitive Deficits After Stroke

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Sepsis

ORG_CITY: FARMINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative The proposed research seeks to understand the molecular mechanisms of caspase-4/-5/-11 noncanonical inflammasomes activation. Non-canonical inflammasomes are large multiprotein complexes that play key roles in the innate immune surveillance of infections and danger, and have been shown to play pivotal roles in various inflammatory and infectious diseases, including sepsis. Completion of the research will produce critical insights into the non-canonical inflammasome signaling, and open a new avenue for developing therapeutic strategies against sepsis and other noncanonical inflammasome-related diseases.

PI_NAMEs: RUAN, JIANBIN  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Adult;Bacterial Infections;Binding;Biochemical;Biological Process;biophysical properties;C-terminal;CASP1 gene;Caspase;Catalytic Domain;Cause of Death;Cell Death;Cell membrane;Child;Communicable Diseases;Complex;Cryoelectron Microscopy;design;Disease;drug development;Electron Microscopy;Elements;Endotoxins;experience;experimental study;Filament;Future;Goals;Gram-Negative Bacteria;Hospitalization;Human;Immunologic Surveillance;improved;In Vitro;in vivo;Infection;Inflammasome;Inflammatory;inflammatory marker;insight;Intervention;Knowledge;Ligand Binding;Ligands;Lipids;Lipopolysaccharides;Mass Spectrum Analysis;Membrane;microbial;Modeling;Molecular;Multiprotein Complexes;Mus;Mutagenesis;N-terminal;Neonatal Mortality;novel strategies;novel therapeutic intervention;oxidized phosphatidyl choline;Patients;Phase;Phospholipids;Play;Process;programs;receptor;reconstitution;recruit;Research;Resolution;Role;sensor;Sepsis;septic patients;Sequence Alignment;Signal Pathway;Signal Transduction;Site;Structure;Testing;Therapeutic;trial design;Variant;VDAC1 gene;X-Ray Crystallography

PROJECT_TITLE: Structural and mechanistic elucidation of non-canonical inflammasome signaling

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Precision Medicine;Rehabilitation;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative Alcohol use disorder (AUD) is a serious public health problem, and current treatments do not address alcohol withdrawal symptoms (AW) and related stress pathophysiology that are associated with high relapse risk and treatment failure in AUD. The proposed research will enroll the more severe subgroup of AUD+AW and test the efficacy of Prazosin in a 12-week randomized controlled trial for improving alcohol use outcomes, other psychological and physical health functioning and patient related outcomes. Positive findings will support the use of Prazosin to reduce heavy drinking outcomes and improve functioning among individuals with AUD and alcohol withdrawal and related stress pathophysiology.

PI_NAMEs: FIELLIN, DAVID ;SINHA, RAJITA  (contact)

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: Accident and Emergency department;addiction;Address;Adrenal Glands;Adrenergic Antagonists;Advertising;Aftercare;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol relapse;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholism;Ambulatory Care;Anxiety;anxiety symptoms;associated symptom;Blood Pressure;Brain;Characteristics;Chronic;chronic alcohol ingestion;Clinical Research;Consult;craving;Data;depressive symptoms;Development;Distress;Dose;Double-Blind Method;drinking;Drug Metabolic Detoxication;Drug Prescriptions;efficacy testing;Enrollment;Enzymes;FDA approved;follow up assessment;follow-up;Functional disorder;functional improvement;Gender;Glucuronides;Goals;Health Care Costs;Heavy Drinking;Hospitals;Human;Hypothalamic structure;improved;Individual;Laboratory Research;Liver;Medical;men;Mental Depression;Mental Health;mood symptom;Neurobiology;noradrenergic;Outcome;Patient Self-Report;patient subsets;Patients;Peripheral;Pharmaceutical Preparations;Phase;physical conditioning;Placebo Control;Placebo Effect;Placebos;Post-Traumatic Stress Disorders;Prazosin;precision medicine;Prevalence;prognostic indicator;Public Health;randomized, clinical trials;Randomized, Controlled Trials;Recording of previous events;recruit;Relapse;relapse risk;Reporting;Research;response;Risk;Role;secondary outcome;Self Assessment;Services;Site;Stress;stress reduction;Subgroup;Surgeon;symptom treatment;Symptoms;Testing;Time;Titrations;Trauma;treatment effect;Treatment Failure;Treatment outcome;Withdrawal Symptom;Woman

PROJECT_TITLE: Prazosin Treatment for Alcohol Use Disorder with Alcohol Withdrawal Symptoms

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Emergency Care;Mental Health;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury;Women's Health Research

ORG_CITY: Columbus

ORG_DEPT: PSYCHOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Public health relevance: Pediatric traumatic brain injury is a major public health problem, affecting lifelong neurobehavioral outcomes and risk for neurological disorders. Understanding the unique contributions of mast cells, long-term microglia sculpting of neural circuits, and biological sex to the pediatric brain’s response to injury could lead to unique, targeted interventions after the common and devastating experience of early life TBI.

PI_NAMEs: LENZ, KATHRYN M. (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: 10 year old;4 year old;Acute;Adolescent;Adult;Affect;age group;Alcohol abuse;Anxiety;Astrocytes;Attention deficit hyperactivity disorder;behavior change;Behavioral;behavioral health;behavioral outcome;biological sex;Blood - brain barrier anatomy;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;brain cell;cell type;Cells;Child;Childhood;Chronic;Cognitive deficits;comparison group;CSF1R gene;Data;Development;Drug abuse;early childhood;early experience;Elderly;Elements;Emergency department visit;Environment;experience;experimental study;FDA approved;Female;first responder;fluid percussion injury;Future;Gene Expression;Genes;Gliosis;Hippocampus;Histology;Hormones;Human;Hypothalamic structure;Immune;improved;Inflammation;Inflammatory;Inflammatory Response;inhibitor;injured;Injury;Intervention;Knowledge;Lateral;Learning;Life;male;mast cell;Mediating;Mediator;Mental Depression;Mental disorders;Microglia;Modeling;Moods;nano-string;Nervous System Disorder;neural circuit;neurobehavioral;neurodevelopment;Neuroimmune;neuroinflammation;Neurological outcome;Neurons;neuropathology;novel;novel therapeutics;Outcome;Patients;Pattern;pediatric emergency;pediatric traumatic brain injury;pharmacologic;Phase;postnatal;preclinical study;Public Health;public health relevance;Rattus;response;response to brain injury;response to injury;Risk;Risk Taking;Rodent;Role;sex;Sex Differences;Shapes;Signal Transduction;social;Social Behavior;social deficits;Social Functioning;social stress;Source;Stress;Stress and Coping;Substance abuse problem;Synapses;Testing;Time;Toddler;transcriptome sequencing;transcriptomics;Traumatic Brain Injury;treatment strategy;Vascular Permeabilities;verbal;Withdrawal;Work

PROJECT_TITLE: Sex differences in neuroimmune function and developmental vulnerability to early life traumatic brain injury


NIH_SPENDING_CATS: Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Clinical Research;Electronic Nicotine Delivery Systems;Emphysema;Health Effects of Indoor Air Pollution;Lung;Prevention;Pulmonary Fibrosis;Tobacco;Tobacco Smoke and Health

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: This study will address major gaps in knowledge regarding the respiratory health risks of e- cigarette use, which is increasingly common in young adults. It will test robust biological hypotheses regarding e-cigarettes and subclinical lung disease using innovative imaging measures developed and applied by the investigative team; moreover, it will examine the role of metal exposure, an established pulmonary toxin, in e-cigarette-related lung injury. The results will be suitable to help inform public health campaigns and regulatory decisions regarding e- cigarettes.

PI_NAMEs: OELSNER, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Acute;Address;Adolescent and Young Adult;Adult;aerosolized;Age;Allergens;Ancillary Study;Animal Model;Area;Arsenic;attenuation;Biological;Blood;Blood flow;Blood Vessels;Carbon Monoxide;Cardiopulmonary;Cardiovascular Diseases;Chromium;Chronic Obstructive Pulmonary Disease;Clinical;clinical predictors;Cobalt;cohort;Cotinine;Development;Devices;Diffusion;e-cigarette aerosols;Electronic cigarette;electronic cigarette use;electronic cigarette user;endothelial dysfunction;Endothelium;falls;follow-up;former smoker;Functional Magnetic Resonance Imaging;General Population;Health;Health Campaign;Hospitalization;Image;improved;Inhalation;innovation;interstitial;Interstitial Lung Diseases;Knowledge;Lead;Link;low dose computed tomography;Lung;Lung Capacity;Lung Diseases;lung injury;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measurement;Measures;Mediation;Metal exposure;Metals;Modification;mortality;Multi-Ethnic Study of Atherosclerosis;Multimodal Imaging;never smoker;New York City;Nickel;Occupational Asthma;Parents;Participant;pre-clinical;primary outcome;Public Health;Pulmonary Emphysema;Pulmonary Fibrosis;pulmonary function;quantitative imaging;recruit;Regulation;respiratory;respiratory health;Risk;Risk Factors;Role;Science;Smoker;Spirometry;Structure;System;Testing;Tetrahydrocannabinol;Thick;Tobacco smoke;Toxin;urinary;Urine;vape pens;vaper;vaping associated lung injury;ventilation;X-Ray Computed Tomography;young adult

PROJECT_TITLE: Metal Exposure and Subclinical Lung Disease in Adult E-cigarette Users

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MORGANTOWN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE Visual impairment is a terrifying prospect. Our long-term goal is to eliminate or reduce this health burden by understanding the biological mechanisms that underlie vision in health and disease. With this goal in mind, we propose to create a Center of Excellence in visual sciences at West Virginia University to strengthen the scientific community focused on understanding processes essential to optimal visual health.

PI_NAMEs: RAMAMURTHY, VISVANATHAN  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Achievement;Address;Advisory Committees;Affect;Appalachian Region;Award;Behavior;Biochemistry;Biological;Biology;Biomedical Engineering;Brain;career;cell type;Centers of Research Excellence;Clinical;Collaborations;Communities;comorbidity;Complex;Core Facility;Coupled;Dedications;Development;Disease;Effectiveness;effectiveness evaluation;Electroretinography;Ensure;Environment;Esthesia;Evaluation;Extramural Activities;Faculty;Faculty Recruitment;Feedback;formative assessment;Funding;Goals;Grant;Health;Health Sciences;Imaging technology;Incidence;Infrastructure;Institution;instrumentation;interdisciplinary approach;Investigation;Light;Mediating;meetings;member;Mentors;Microscope;Morphology;Motor;multidisciplinary;National Institute of General Medical Sciences;Network Infrastructure;Neurosciences;novel strategies;Ophthalmology;Opsin;Optical Coherence Tomography;Outcome;Patients;Pilot Projects;Population;Positioning Attribute;Prevention approach;Process;Productivity;professor;Program Effectiveness;programs;recruit;Research;Research Infrastructure;Research Personnel;Research Support;response;Rest;Retina;Retinal Ganglion Cells;Review Committee;Scientist;senior faculty;Sensory;single-molecule FRET;Specific qualifier value;Strategic Planning;Structure;success;symposium;Synaptic Transmission;System;Talents;Technology;tenure track;Time;tool;trafficking;Translating;Transmission Electron Microscopy;ultra high resolution;United States National Institutes of Health;Universities;Vesicle;Vision;vision science;Visual;Visual disability;Visual impairment;visual information;Visual System;West Virginia;Work

PROJECT_TITLE: Visual Sciences Center of Biomedical Research Excellence


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Eye Disease and Disorders of Vision

PROJECT_TERMS: Advisory Committees;Affect;Award;Budgets;career development;Centers of Research Excellence;Communities;Counseling;Data;Development;Educational process of instructing;Effectiveness;Environment;Evaluation;Event;experience;Extramural Activities;faculty mentor;Familiarity;Feedback;Funding;Goals;Graduate Education;Grant;Growth;Health Sciences;holistic approach;Human Resources;Infrastructure;Institution;Interdisciplinary Study;Intervention;Investigation;Investments;Laboratories;Lead;meetings;Mentors;Modification;Morphology;National Institute of General Medical Sciences;next generation;Peer Review;Process;Productivity;programs;recruit;Research;Research Personnel;Resource Sharing;Resources;Review Committee;Science;Scientist;senior faculty;Services;Study Section;success;summer research;symposium;synergism;Technology;Time;undergraduate student;United States National Institutes of Health;Update;Vision;vision science;Visual disability;Visual System

PROJECT_TITLE: VS-CoBRE Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Disability Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

PI_NAMEs: GATESMAN-AMMER, AMANDA SUSANNE (contact)

PROJECT_TERMS: Adult;Affect;Age;age related;Age related macular degeneration;aging population;American;Basic Science;Behavior;Biological Assay;Biology;Biophysics;Blindness;Centers of Research Excellence;Child;Chronic;Communities;Complex;cone-rod dystrophy;Contract Services;Core Facility;data acquisition;Data Analyses;design;Development;Diabetic Retinopathy;disability;Disease;Dissection;Electron Microscope;Electroporation;Ensure;Environment;Equipment;experience;Experimental Designs;Extramural Activities;Eye;Eye diseases;Fees;fluorescence imaging;Funding;Genetic;Glaucoma;Goals;Health;histological specimens;Hour;imaging modality;imaging system;improved;Infrastructure;Injections;Institution;instrumentation;Investments;Journals;Lead;Life;Mediating;member;Methods;microscopic imaging;Molecular;Morphology;multidisciplinary;new technology;novel therapeutic intervention;Ocular Pathology;operation;Persons;Postdoctoral Fellow;Preparation;Prevalence;Principal Investigator;Process;Productivity;programs;Publications;quality assurance;Quality of life;recruit;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Retinitis Pigmentosa;Sampling;Services;single-molecule FRET;Slide;Structure;Students;subretinal injection;success;superresolution imaging;superresolution microscopy;Syndrome;System;Technology;therapeutic development;tool;Training;Translational Research;Transmission Electron Microscopy;transmission process;ultrasound;Universities;Vision;Vision research;vision science;Vision Tests;Visual;Visual Acuity;Visual impairment;visual processing;Wages;West Virginia

PROJECT_TITLE: Visual Function & Morphology Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: ROBICHAUX, MICHAEL  (contact)

PROJECT_TERMS: adenovirus mediated delivery;Anabolism;appendage;base;Binding;Biochemical;Biological Assay;Biology;Body Regions;Cell membrane;Cells;Cellular biology;Centers of Research Excellence;Centrioles;Cilia;ciliopathy;Color;Communities;Complement;CRISPR/Cas technology;Data;Disease;Distal;Docking;early onset;Electron Microscopy;Endoplasmic Reticulum;Environment;Event;experimental study;Fluorescence;Fluorescence Microscopy;Fostering;G-Protein-Coupled Receptors;Genetic;Genetic Models;Golgi Apparatus;Homeostasis;imaging approach;Imaging Device;interest;kinetosome;Knock-in;Knock-in Mouse;Light;Link;Location;Maps;Mediating;Membrane;Mentors;Messenger RNA;Methods;Microscopy;Molecular;molecular pathology;molecular scale;mouse genetics;mouse model;Movement;Mus;Mutation;nanoscale;Neurons;novel;Pathogenicity;Pathway interactions;Photons;photoreceptor cell inner segment;Photoreceptors;Phototransduction;programs;protein protein interaction;Proteins;Research;Retina;Retinal Diseases;retinal neuron;Retinal Pigments;retinal rods;Retinitis Pigmentosa;Rhodopsin;Ribosomes;Rod;Role;Rough endoplasmic reticulum;Sensory;Site;Structure;superresolution microscopy;System;Techniques;Testing;Thinness;Time;trafficking;Translations;ultra high resolution;Viral Vector;Vision;Vision research;vision science;Visual Signal Transduction Pathway

PROJECT_TITLE: Molecular -Scale Mapping of Rhodopsin Trafficking in Mammalian Rod Photoreceptors


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Services;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Radiation Oncology;Rare Diseases;Rehabilitation

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: RELEVANCE Survival rates for many childhood and adolescent cancers have improved at a remarkable pace over the past five decades. The CCSS cohort has been the source of some of the most significant publications to date addressing the long-term mortality, morbidity and quality of life of survivors of childhood cancer. Understanding the risk for late effects of childhood cancer and its therapy provides the basis for health screening recommendations and interventions that can mitigate long-term health problems in this high-risk population.

PI_NAMEs: ARMSTRONG, GREGORY  (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Address;Adolescent;Age;age acceleration;age related;Aging;Behavior;biobank;Biological;Cancer Survivor;Cancer Survivorship;care costs;career;Caring;Cessation of life;Child;Childhood;childhood cancer survivor;Childhood Cancer Survivor Study;clinical care;cloud based;cohort;Cohort Studies;Communities;comorbidity;Data;data access;Data Analyses;Data Collection;Data Reporting;data sharing;data tools;Diagnosis;Disease susceptibility;DNA sequencing;Early Diagnosis;Ecosystem;Eligibility Determination;Ensure;Evaluation;exome;follow-up;Functional disorder;functional outcomes;Funding;Future;Genetic;genetic analysis;genetic information;Genetic Predisposition to Disease;genome sequencing;Genotype;Germ Lines;Goals;Grant;Guidelines;Health;health related quality of life;Health Services Research;Healthcare;Healthcare Systems;high risk population;Home;Immunotherapy;improved;Infrastructure;innovation;Institution;International;Intervention;Intervention Trial;Investigation;Investigator-Initiated Research;K-Series Research Career Programs;Knowledge;Late Effects;Level of Evidence;Life;life span;Life Style;Longterm Follow-up;Malignant Childhood Neoplasm;Malignant Neoplasms;Manuscripts;member;Modeling;Molecular;Morbidity - disease rate;mortality;multidisciplinary;Neurocognitive;novel therapeutics;Online Systems;Outcome;Participant;Patient Outcomes Assessments;Patients;Pediatric Oncology Group;Performance;Phenotype;Physiological;Population;Positioning Attribute;premature;Prevention;Productivity;proton beam;Provider;Publications;Publishing;Quality of life;Radiation;randomized trial;Recommendation;recruit;Research;Research Infrastructure;Research Personnel;Research Support;Resources;Risk;Role;sample collection;Sampling;screening;screening guidelines;shared database;sharing platform;Siblings;SNP array;Source;Strategic Planning;Surveys;Survival Rate;Survivors;survivorship;Update;Visualization;Vulnerable Populations;whole genome;working group

PROJECT_TITLE: Childhood Cancer Survivorship Study


NIH_SPENDING_CATS: Microbiome

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: The proposed research is high.y re.evant to pub.ic hea.th because it wi.. great.y advance mechanistic understanding of how FMOs promote host defense against infection in vivo. Moreover, the reagents, assays, new mode. organisms, and know.edge gained through this deve.opmenta. project wi.. open new avenues of research into innate immunity and FMO function and he.p create a path forward for the rationa. design of host- directed therapeutics against bacteria. infections and microbiota dysbiosis. The proposed research is re.evant to the part of the NAH’s mission that pertains to deve.oping fundamenta. know.edge that wi.. he.p to reduce the burden of human disease.

PI_NAMEs: IRAZOQUI, JAVIER ELBIO (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Address;Aging;Bacteria;Bacterial Infections;Biological Assay;Body Weight;Brain;Caenorhabditis;Communication;Data;Defect;design;Disease;dysbiosis;Eating;Enzymes;flavin-containing monooxygenase;Future;Genes;Genetic;Genomics;gut-brain axis;Hepatic;High Fat Diet;Homeostasis;Homo;Host Defense;Host Defense Mechanism;host-microbe interactions;Human;human disease;improved;in vivo;Infection;Ink;innovation;intestinal epithelium;Intestines;Label;Mediating;Mediator;Membrane Transport Proteins;Methods;microbiota;Mission;Mixed Function Oxygenases;Mus;Natural Immunity;Nervous System;Neurons;novel;Organism;Outcome;overexpression;oxidation;Pathway interactions;Pattern;Peptides;peroxidation;PPAR alpha;prevent;protective effect;Reactive Oxygen Species;Reagent;Research;Research Support;Resistance;Site;Source;Stress;Testing;Therapeutic;therapeutic target;Tissues;Work;Xenobiotics

PROJECT_TITLE: FLAVIN-CONTAINING MONO-OXYGENASES AS NOVEL INNATE IMMUNITY EFFECTORS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-M(90)]


NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Despite RAS proteins being frequently mutated in human cancers (~25%), efforts to develop targeted therapies against RAS proteins have been largely unsuccessful until recently (06/21) when FDA approved the first drug to shut down the activity of a cysteine-containing oncogenic mutant of RAS that is prevalent in patients with advanced non-small cell lung cancer. This is the first in a rapidly expanding set of related inhibitors under development, which take advantage of the reactivity of cysteine (C12 in the case of KRAS G12C) to permanently attach drugs to target proteins. We propose studies to investigate the underlying mechanism of RAS inactivation by these inhibitors and how oxidation modulated by the tumor environment may impact the response to treatment by taking a comprehensive bench-to-bedside approach based on novel approaches and high-end technologies.

PI_NAMEs: CAMPBELL, SHARON L (contact);FURDUI, CRISTINA MARIA;POOLE, LESLIE B

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: 3-Dimensional;Acceleration;Acrylamides;Address;adduct;Affect;Affinity;Baptist Church;bench to bedside;Binding;Biochemical;Biological;Biological Assay;Cancer cell line;Cell Culture Techniques;cell growth;Cell Line;Cell membrane;Cells;Chemicals;Chronic;Clinical;clinical development;clinical efficacy;Clinical Trials;cold temperature;Complex;Comprehensive Cancer Center;Computer Analysis;Computer Models;covalent bond;Crystallography;Cysteine;Data;Development;dosage;Drug Design;drug discovery;Environment;Exhibits;experimental study;FDA approved;Fluorescence;Foundations;Frequencies;Future;Gene Frequency;Genetic;Goals;Guanine Nucleotides;Human;Hydrogen Peroxide;improved;In Situ;In Vitro;inhibitor;Kinetics;Knowledge;KRAS oncogenesis;KRAS2 gene;KRASG12D;Ligands;Ligation;Location;lung cancer cell;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Medicine;Methods;Modeling;Modification;Molecular Conformation;molecular dynamics;mutant;Mutate;Mutation;next generation sequencing;Non-Small-Cell Lung Carcinoma;novel strategies;Nucleotides;Oncogenic;Operative Surgical Procedures;Organoids;Output;Oxidants;oxidation;Oxidation-Reduction;Pathologic;Patient Care;Patients;Pharmaceutical Preparations;Physiological;Positioning Attribute;preclinical efficacy;Predisposition;prevent;Production;Property;Protein Isoforms;Proteins;Publications;RAS genes;ras Proteins;Reaction;Recombinant Proteins;resistance mechanism;response;Sampling;scaffold;Series;Signal Transduction;Site;Smoking;spatiotemporal;Specimen;Spectrum Analysis;Sulfinic Acids;System;targeted treatment;Technology;Testing;Therapeutic;therapy development;therapy resistant;thioether;Time;Tissues;Treatment Efficacy;treatment response;tumor;Tumor Tissue;tumorigenesis;Work

PROJECT_TITLE: KRAS G12C: Kinetic and Redox Characterization of Covalent Inhibition

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: NEWARK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS THE STATE UNIV OF NJ NEWARK

ORG_STATE: NJ

PHR: Narrative Because its volume is reduced in most psychiatric disorders (Goodkind et al. 2015; Downar et al. 2016), the insula has emerged as a promising target for therapeutic interventions, particularly those involving transcranial or deep brain stimulation. However, progress in this field has been hindered by the lack of high- resolution physiological data about insula signaling. The experiments we propose will shed light on the coding properties and role of insula neurons, thereby facilitating the development of novel therapies.

PI_NAMEs: PARE, DENIS  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Acceleration;Address;Affect;Anterior;Area;Automobile Driving;Behavioral;cell type;Cells;Cephalic;Code;Cognitive;Computers;Data;Deep Brain Stimulation;Development;Emotions;Event;expectation;experimental study;Frequencies;Functional Magnetic Resonance Imaging;Human;Impairment;insight;Insula of Reil;Interoception;Learning;Light;light intensity;Mediating;Mental disorders;Methods;Neurons;novel;novel therapeutics;Opsin;optogenetics;Outcome;Phase;Physiological;Process;Property;Psychological reinforcement;Rattus;recruit;Resolution;Resources;response;Rewards;Role;Signal Transduction;Site;Stimulus;Synapses;targeted treatment;Techniques;Testing;Therapeutic Intervention;therapeutic target;Time

PROJECT_TITLE: SIGNALING OF SALIENCE AND PREDICTION ERRORS BY THE INSULA

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences

PI_NAMEs: BERGERON, SADIE A (contact)

PROJECT_TERMS: Ablation;Adult;Affect;Auditory system;Axon;axon guidance;Behavior;behavior test;Behavioral;behavioral response;Bioinformatics;Biological Models;Brain;cell type;Cells;Centers of Research Excellence;Clinical;comorbidity;comparative;Complex;Core Facility;Data;Defect;Development;diagnostic strategy;Disease;Electroretinography;Embryo;Ephrins;Etiology;experimental study;Eye;Eye Movements;Functional disorder;Gene Expression;Gene Expression Profiling;gene network;Genes;Genetic;Genetic Models;Genetic Predisposition to Disease;Genetic Transcription;genome wide association study;Genomics;glutamatergic signaling;Glutamates;Goals;Homeobox;Human;human disease;Human Genome;in vivo;insight;Interneurons;Knock-out;Knowledge;Link;Measures;Mediating;Mentors;Microscopy;Modeling;Molecular;Molecular Genetics;Morphology;Motor;mRNA Expression;Mus;mutant;Mutate;Nervous System;neural circuit;Neural Pathways;Neuroanatomy;neurodevelopment;Neurodevelopmental Disorder;neuromechanism;Neuronal Differentiation;Neurons;Neurophysiology - biologic function;neurotransmission;novel;Orthologous Gene;Patients;Pharmacology;Phenotype;Play;Positioning Attribute;Presynaptic Terminals;Prevention strategy;programs;protein expression;Reporting;Research;Research Project Grants;response;Retinal Ganglion Cells;Rodent;Role;Saccades;Schizophrenia;Sensory;sensory system;Specific qualifier value;Structure;superior colliculus Corpora quadrigemina;Symptoms;synaptogenesis;Techniques;Tectum Mesencephali;Testing;Time;transcription factor;Vertebrates;Vision;vision development;vision science;Visual;visual processing;visual stimulus;Visual System;visual tracking;Work;Zebrafish

PROJECT_TITLE: Investigating Novel Transcriptional Mechanisms for Visual Neural Circuit Development and Function using Zebrafish


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

PI_NAMEs: PALKO, JOEL R (contact)

PROJECT_TERMS: Advanced Development;Affect;Animal Model;anterior chamber;arteriole;Award;Axon;Axonal Transport;Biomechanics;Blindness;Blood flow;Blood Vessels;Cannulations;career;Cell Death;Centers of Research Excellence;Cessation of life;Chemicals;Collagen;Connective Tissue;crosslink;Data;Development;Diagnosis;Disease;effective therapy;Environment;Event;Eye;Family suidae;Foundations;Functional disorder;Funding;genipin;Glaucoma;Goals;Hour;Hypoxia;imaging system;Imaging Techniques;Impairment;improved;in vivo;Individual;innovation;insight;Ischemia;Label;Manipulative Therapies;Measurement;Measures;mechanical properties;Mechanics;Mediating;Mentors;Mentorship;Methodology;Microbubbles;Modeling;modifiable risk;multidisciplinary;novel;novel strategies;ocular imaging;ophthalmic artery;Optic Disk;Optic Nerve;Optical Methods;Papillary;Penetration;Perfusion;perineural;Persons;Physicians;Physiologic Intraocular Pressure;pre-clinical;Predisposition;pressure;prevent;programs;Rattus;Rattus norvegicus;Research;response;retinal ganglion cell degeneration;Retinal Ganglion Cells;Risk Factors;Rodent Model;Role;Scientist;Sclera;System;Systemic blood pressure;Techniques;Technology;Testing;Therapeutic;therapeutic evaluation;Thick;Tissues;treatment strategy;Ultrasonography;ultrasound;vision science;Visualization

PROJECT_TITLE: Influence of Ocular Biomechanics on Optic Nerve Head Perfusion


ADMINISTERING_IC: OD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: EDINBURG

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

ORG_STATE: TX

PHR: The overarching objective of this project is to establish in the US, for the first time, the technologies required to genetically engineer laboratory opossums (which are born at the developmental stage of a 6-week human embryo) for the purpose of answering critical biomedical questions that cannot be answered by research with other laboratory animals. One of the first genetically engineered opossums will be deficient in a gene (Pten) believed, when deficient, to predispose to Autism Spectrum Disorder (ASD). Key outcomes of the project will be to enable establishment of a new animal model for research on ASD, and to make gene editing technology accessible to investigators from other US institutions for novel research with genetically engineered laboratory opossums.

PI_NAMEs: VANDEBERG, JOHN L (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Address;animal breeding;Animal Model;Animals;Area;Auditory;autism spectrum disorder;Behavior;Behavioral;Biomedical Research;Breeding;Characteristics;Collaborations;comparative;Comparative Biology;comparative genomics;Copulation;cost;CRISPR/Cas technology;Development;Developmental Process;Didelphidae;DNA analysis;Ear;Egg Shell;Embryo;Embryology;Experimental Models;experimental study;external ear auricle;Female;Future;gene editing technology;Gene Modified;gene-editing approach;Generations;Genes;Genetic Engineering;Genetically Modified Animals;Genome;Genomic DNA;genomic locus;Genotype;Germ Lines;Grant;Heterozygote;Homozygote;Hour;Human;human disease;Implant;in vivo;Inbred Strain;induced pluripotent stem cell;innovation;Institution;Japanese;Japanese Population;KDM1A gene;Knock-out;knockout gene;Laboratories;Laboratory Animals;Letters;Literature;Mammals;Marsupialia;Medicine;Methods;model of autism spectrum disorder;Modeling;Monodelphis;Monodelphis Domestica;Monophenol Monooxygenase;mosaic;Mus;Natural regeneration;neurodevelopment;Neurodevelopmental Disorder;next generation sequencing;novel;Outcome;Penetration;Preparation;Procedures;Process;programs;Protocols documentation;PTEN gene;reproductive;Research;Research Personnel;Research Project Grants;Resistance;Resources;Rodent;Rodent Model;Role;Science;Siblings;Snake Venoms;success;T-Lymphocyte Subsets;Technology;Time;transmission process;Weaning;Work

PROJECT_TITLE: Creation of Knockout Laboratory Opossums

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: WEBB, BRADLEY A (contact)

PROJECT_TERMS: Amino Acids;Arginine;autosome;Basic Amino Acid Transport Systems;Biological Assay;Blindness;Buffers;Candidate Disease Gene;Cell Line;Cell membrane;cell type;Cells;Centers of Research Excellence;Chimera organism;Data;detection of nutrient;Development;Disease;Electroretinography;Endosomes;Environment;Epithelial Cells;Family;Fluorescent in Situ Hybridization;Functional disorder;gain of function;gene therapy;Genes;Health;Human;In Vitro;Inner Nuclear Layer;insight;Kinetics;Knock-out;Knockout Mice;Knowledge;Link;Literature;loss of function;Lysosomes;Mediating;member;Mendelian disorder;Mentors;Metabolic;Metabolism;mouse model;Mus;mutant;Mutation;Needs Assessment;Neurons;novel;novel therapeutic intervention;Orphan;Outcome;Outcome Study;Pathogenesis;Pathology;Phenotype;Photoreceptors;Play;prevent;programs;Recombinant Proteins;Regulation;Reporting;Research;response;Retina;Retinitis Pigmentosa;RNA;Role;sensor;Serum;Signal Transduction;Site;solute;Starvation;Structure;Structure of retinal pigment epithelium;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Thinness;Tissue Sample;transcriptomics;vector;Vision;vision science;Zebrafish

PROJECT_TITLE: Retinal amino acid transport in health and disease


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PUBLIC HEALTH RELEVANCE/ PROJECT NARRATIVE The next and exciting phase of HIV prevention worldwide will involve the use of long‐acting injectable agents: cabotegravir has been approved as a shot every 8 weeks for PrEP (with the WHO expanding its use in July 2022 worldwide) and lenacapavir is being evaluated as an injection every 6 months to prevent HIV in order to make pre‐exposure prophylaxis (PrEP) easier and more widely available. Our laboratory has been studying the use of small hair samples and urine metrics to monitor for PrEP exposure for many years and this application will monitor cabotegravir and lenacapavir exposure in hair samples in important long‐acting PrEP demonstration projects in East Africa, Botswana with breastfeeding mothers, and with lenacapavir in two major trials. Our goal with this application is to minimize failures or “breakthroughs” on these new PrEP agents and find easy‐to‐ collect‐and‐store methods of evaluating exposure and optimizing the success of long‐acting PrEP.

PI_NAMEs: GANDHI, MONICA  (contact)

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;adjudication;Africa;Age;AIDS prevention;Anti-Retroviral Agents;Antibodies;antibody test;antiretroviral therapy;Behavior;Biological;Biological Assay;Biology;Blood;Body mass index;Botswana;Breast Feeding;Breastfed infant;Capsid;Clinical Trials;Collection;Communities;Community Health;Dose;Drug Exposure;Drug Kinetics;Dryness;Exposure to;Failure;FDA approved;Future;Goals;Grant;Hair;HIV;Human Milk;Individual;Infant;Infrastructure;inhibitor;Injectable;Injections;insight;Integrase Inhibitors;Intervention;Intramuscular;Investigation;Kenya;Knowledge;Laboratories;Longitudinal Studies;low income country;Measures;Medicine;men;Methods;Modality;Modeling;Monitor;Mothers;Mutation;next generation;novel;open label;Oral;Outcome;Outcome Assessment;Paper;Participant;perinatal period;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Plasma;Play;point of care;Population;Population Heterogeneity;Postpartum Period;Postpartum Women;pre-exposure prophylaxis;Pregnancy;prevent;Prevention;Prevention strategy;Productivity;public health intervention;public health relevance;Publishing;Research;Resistance;Risk;Risk Assessment;Role;Sampling;Sapphire;Scalp structure;seroconversion;sex;Spottings;Subcutaneous Injections;success;Tail;Tenofovir;Testing;Therapeutic;Time;time interval;tool;Uganda;Urine;Visit;Woman

PROJECT_TITLE: “Hair Lengthening”: Using Hair Levels to Interpret Long-Acting PrEP Studies.

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Nutrition;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: NARRATIVE Eosinophilic gastrointestinal diseases (EGIDs) of the upper GI tract are predominantly food-triggered chronic eosinophilic disorders with significant impact on quality of life and predictive, non-invasive diagnostic testing and treatments are sorely lacking. This proposal aims to expand and deepen our knowledge of two types of immune cells, namely eosinophils and specialized T cells, in EGID pathogenesis in a cohort of well- characterized EGID patients. The knowledge gained will ultimately impact patient care by improving diagnostics, providing biomarkers for monitoring disease activity and identifying potential targets for novel therapeutics.

PI_NAMEs: KUANG, FEI LI  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Adrenal Cortex Hormones;Affect;Allergic;Allergic Disease;Area;Automobile Driving;Award;Biological Markers;Biological Products;Blood;career development;Career Mobility;Caring;Cell surface;cell type;Cells;Characteristics;Chronic;Cicatrix;Clinical;Clinical Research;cohort;cytokine;Data;Dedications;Deglutition;Diagnosis;Diagnostic;Diagnostic tests;Diet;dietary;Disease;Disease remission;Disparate;Disseminated eosinophilic collagen disease;duodenitis;Elemental Diets;environmental allergy;eosinophil;Eosinophilia;eosinophilic asthma;Eosinophilic Esophagitis;Eosinophilic Gastritis;Eosinophilic Gastrointestinal Disease;eosinophilic inflammation;Esophagus;Evaluation;Flow Cytometry;Food;food antigen;Food Hypersensitivity;Gastrointestinal Diseases;Gastrointestinal tract structure;Genes;Human;Hypersensitivity;IgE;IL17 gene;IL5 gene;Immune;Immune response;Immunology;Immunophenotyping;improved;Inflammation;Inflammatory;innovation;interest;Interferon Type II;Interleukin-13;Interleukin-5;K-Series Research Career Programs;Knowledge;Lymphocyte;Mediating;medical schools;memory CD4 T lymphocyte;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Molecular;Monitor;Morbidity - disease rate;new therapeutic target;noninvasive diagnosis;novel;Outcome Measure;Pathogenesis;Pathogenicity;Pathway interactions;Patient Care;Patient Outcomes Assessments;Patients;Physicians;Play;Process;Production;professor;Publishing;Quality of life;recruit;Research;Resolution;response;rhinoconjunctivitis;RNA;RNA purification;Role;Sampling;Scientist;single-cell RNA sequencing;Specificity;Steroids;Symptoms;T-cell receptor repertoire;T-Lymphocyte;Technology;Testing;Th2 Cells;Tissue-Specific Gene Expression;Tissues;Training;Transcript;transcriptome sequencing;treatment effect;treatment response;Universities;Upper digestive tract structure

PROJECT_TITLE: Deciphering the roles of eosinophils and T lymphocytes in EGID


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Pediatric;Prevention;Substance Misuse;Tobacco

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE This K01 Mentored Research Scientist Career Development Award aims to understand how young adults’ (age 18-25) social media use affects their nicotine vaping and to identify intervention targets that mitigate social media’s impact on vaping. A two-arm randomized controlled trial (incentivized reduction in social media use vs. social media use as usual) will examine potential mechanisms of relationships between social media use and vaping behavior; focus groups will explore intervention strategies for reducing young adults’ social media use and vaping and improving their mental health. Results will inform a future digital intervention targeting social media use and vaping, and may have regulatory implications for controlling the spread of vaping-related content on social media.

PI_NAMEs: VOGEL, ERIN ALYSSA (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: 2 arm randomized control trial;Address;Affect;Age;Behavior;behavioral health;California;Cellular Phone;Data;Development;digital;digital health;digital intervention;digital tool;Distress;effective intervention;electronic cigarette use;experience;experimental study;Exposure to;Focus Groups;follow-up;Frequencies;Future;Generations;Goals;Health;Health behavior;improved;Incentives;Intervention;K-Series Research Career Programs;Learning;Link;Measurement;Measures;media use;Mediator;Mental Health;Mentors;Mentorship;Methodology;Nicotine;Participant;Patient Self-Report;Personal Satisfaction;Persons;Prevalence;programs;Randomized;Reporting;Research;Research Personnel;Risk;Risk Behaviors;Risk Factors;Scientist;social;social media;Statistical Models;Stress;Symptoms;Testing;therapy development;Time;Tobacco use;Training;Universities;vaping;vaping nicotine;young adult

PROJECT_TITLE: Identifying and Addressing the Effects of Social Media Use on Young Adults' E-Cigarette Use: A Solutions-Oriented Approach

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]