NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Converging lines of evidence indicate that chromatin organization is dynamic during development, plays a key role in orchestrating the transcriptional programs that are necessary for lineage specification, and is critical for correct brain development and function. In this pilot project, we aim to utilize a human stem cell model of CTCF- related disorder (CRD), a rare neurodevelopmental disorder caused by mutations in the chromatin organizer CTCF, to study the role of this understudied protein in neural differentiation and brain development. This research promises to shed light on the molecular mechanisms underlying neurodevelopmental disorders that stem from dysfunctional chromatin organization, such as CRD, and offer potential insights into novel therapeutic targets.

PI_NAMEs: WATSON, LAUREN ASHLEY  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Apoptosis;Applications Grants;Architecture;autism spectrum disorder;autism symptoms;behavioral impairment;Binding;Brain;Categories;CCCTC-binding factor;Cellular Assay;Chromatin;Chromatin Loop;chromosome conformation capture;cohesin;combinatorial;Complex;Coupled;Craniofacial Abnormalities;Data;de novo mutation;Defect;Development;Developmental Delay Disorders;developmental disease;Developmental Gene;diagnostic tool;Disease;DNA Binding;domain mapping;Down's Syndrome;Epigenetic Process;epigenomics;Etiology;Foundations;Functional disorder;Funding;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;genome-wide;Genomics;human model;human pluripotent stem cell;human stem cells;Impaired cognition;Individual;insight;Intellectual functioning disability;interdisciplinary approach;Knowledge;Link;Malignant Neoplasms;Maps;Mediating;Missense Mutation;Molecular;Mus;Mutation;nerve stem cell;Nervous System Disorder;neural;neurodevelopment;Neurodevelopmental Disorder;Neuronal Differentiation;Neurons;new therapeutic target;novel diagnostics;Nuclear;Nuclear Lamina;Organoids;Outcomes Research;Pathogenesis;Pilot Projects;Play;Positioning Attribute;Process;programs;Proteins;Regulation;Research;Research Project Grants;Resolution;risk variant;Role;severe intellectual disability;Shapes;spatiotemporal;Specific qualifier value;Specificity;stem;stem cell differentiation;stem cell model;stem cell proliferation;Structure;targeted treatment;Techniques;three-dimensional modeling;Transcriptional Regulation;Zinc Fingers

PROJECT_TITLE: Analysis of CTCF Function in Neurodevelopment

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-8 (01)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: RENTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: PROVIDENCE HEALTH & SERVICES - OREGON

ORG_STATE: WA

PHR: Project Narrative High concentrations of the cytokine TGFβ in the tumor microenvironment contribute to cancer progression by facilitating tumor proliferation and metastasis while simultaneously inhibiting the function and differentiation of immune cells. Detecting and quantifying TGFβ in vivo would be a valuable diagnostic tool for clinicians as they assess treatment options and monitor patient responses to immunotherapy. The proposed 64Cu-Fc:TβRII PET radiotracer has the potential to fulfill this clinical unmet need.

PI_NAMEs: YOUNG, KRISTINA H (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Acetic Acids;Animals;Anti-Inflammatory Agents;Antibodies;Antiinflammatory Effect;Binding;Biological;cancer imaging;Cancer Prognosis;Cells;Chelating Agents;chemotherapy;Chemotherapy and/or radiation;Clinical;cohort;Copper;Copper Chelation;CXCR3 gene;cytokine;Cytotoxic Chemotherapy;design;Detection;diagnostic tool;dosage;Dose;efficacy evaluation;Elements;Enzyme-Linked Immunosorbent Assay;Evaluation;Event;experimental study;extracellular;Extracellular Domain;Extracellular Space;Fc Immunoglobulins;Flow Cytometry;Genetic Transcription;Growth Factor;Human;IgG2;Image;imaging modality;Immune;Immune response;Immune system;Immunocompetent;ImmunoPET;immunoregulation;Immunosuppression;Immunotherapy;improved outcome;in vivo;in vivo imaging;in vivo monitoring;Incubated;Inflammatory;Label;Ligands;Link;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;Membrane;Methods;Modeling;Monitor;Mus;Neoplasm Metastasis;Noise;non-invasive imaging;novel;Pathway interactions;Patient Monitoring;patient response;Positron-Emission Tomography;preclinical efficacy;prevent;Production;Proliferating;protein purification;Quantitative Reverse Transcriptase PCR;radiation response;Radiation therapy;Radioactive;Radioimmunoconjugate;Radiolabeled;radiotracer;receptor;Recombinant Proteins;Research;Role;scaffold;Signal Transduction;Solubility;Standardization;Staphylococcal protein A-sepharose;Testing;Time;Titrations;tool;treatment strategy;triazacyclononane;tumor;tumor microenvironment;tumor progression;tumor-immune system interactions;uptake;Validation

PROJECT_TITLE: Develop a PET radiotracer suitable for in vivo imaging of TGFβ

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-X (M2)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: RICHMOND

ORG_NAME: VA VETERANS ADMINISTRATION HOSPITAL

ORG_STATE: VA

PHR: Neurogenic osteoporosis is a common complication of spinal cord injury (SCI) that is associated with low impact bone fractures. It is concerning that more than 46,000 Veterans affected with SCI and are at risk of osteoporosis and possible low impact fractures. About fifty percent of all individuals with SCI will develop low impact fracture in their life time. The management of osteoporosis-related fractures can impose substantial economic burden on the health care system, the individual and the families. Previous studies did not succeed in reversing the process of bone loss after SCI. In the present pilot study, we will evaluate the effect of Neuromuscular Electrical Stimulation Resistance Training in combination with oral Vitamin D supplementation, on bone quality in Veterans with chronic SCI, using a randomized experimental design.

PI_NAMEs: IFON, DORA E. (contact)

PROJECT_TERMS: Address;Adherence;Affect;Age Years;Alkaline Phosphatase;Analysis of Variance;Androgens;Attenuated;attenuation;Biological Assay;Biological Markers;Blood specimen;bone;Bone Density;bone health;bone loss;bone quality;Bone remodeling;Bone Resorption;bone turnover;Calcium;Chronic;Clinical;Collagen Type I;comorbidity;Complication;Consensus;crosslink;Cyclophosphamide;Data;demineralization;Deterioration;Disease;Distal;Dose;Dual-Energy X-Ray Absorptiometry;Economic Burden;Electric Stimulation;Enrollment;Evaluation;Exclusion;Exercise;experience;Experimental Designs;Family;Fatty acid glycerol esters;Femur;Fracture;Healthcare Systems;Home;Hydroxyproline;improved;Individual;Injury;Intervention;Intramuscular;kinematics;Life;Limb structure;Link;long bone;Magnesium;Magnetic Resonance Imaging;Measurement;Measures;mechanical load;Medical;Medical Research;Microscopic;Motor;Movement;Muscle;muscle hypertrophy;N-terminal;neuromuscular stimulation;Oral;Osteogenesis;Osteoporosis;osteoporosis with pathological fracture;Paralysed;Participant;Persons;Pharmacologic Substance;Physical activity;Pilot Projects;post intervention;Probability;Process;Procollagen;Property;Protocols documentation;PTH gene;Quality of life;Randomized;rehabilitation paradigm;Rehabilitation therapy;Replacement Therapy;resistance exercise;Risk;Role;Serum;Skeletal Muscle;Spinal cord injury;Structure;substantia spongiosa;Supplementation;Surface;telehealth;tibia;Time;Training;trial design;Veterans;Vitamin D;Vitamin D supplementation;Work

PROJECT_TITLE: Effects of Electrical Stimulation and Vitamin D supplementation on Bone Health Following Spinal Cord Injury.

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Networking and Information Technology R&D (NITRD)

ORG_DEPT: PHARMACOLOGY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Therapeutic nucleic acids have emerged as a novel approach to treat human diseases that are resistant to treatment by traditional small molecule drugs. Molecular simulations can assist in the design and optimization of therapeutic nucleic acids by providing insights into and generating hypotheses about the atomic details of their mechanisms. We propose to improve the accuracy of computational models of therapeutic nucleic acids by enabling the efficient generation of accurate force field parameters for a wide range of covalently modified RNA residues—including glycol nucleic acid analogs that are important for the function of gene silencing small interfering RNAs—and to apply these in molecular simulations aimed at understanding how RNA modifications impact the ability of these compounds to recognize their target genes.

PI_NAMEs: CAVENDER, CHAPIN E (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;Amber;Base Pairing;Behavior;Benchmarking;Biological;biophysical analysis;career;Chemicals;cheminformatics;Chemistry;computational chemistry;Computer Assisted;Computer Models;computer studies;Data Set;Dependence;design;Disease;Disease Resistance;Drug Design;drug discovery;Exhibits;functional group;gene function;Gene Silencing;Generations;Genes;Glean;Glycols;Guide RNA;human disease;improved;Infrastructure;insight;intermolecular interaction;Isomerism;Kinetics;Knowledge;Laboratories;Language;Leadership;Measurement;melting;Messenger RNA;Methods;MicroRNAs;Modeling;Modification;Molecular;Molecular Conformation;molecular dynamics;novel strategies;Nuclear Energy;nucleic acid analog;nucleic acid-based therapeutics;Nucleic Acids;nucleobase;Nucleotides;Oligonucleotides;open source;Pathway interactions;Perception;Pharmaceutical Preparations;pharmacologic;Phenotype;Physics;Positioning Attribute;Potential Energy;Process;Productivity;Property;Proteins;quantum;quantum chemistry;Quantum Mechanics;rational design;Reproducibility;Research;Research Personnel;RNA;RNA Interference;Role;Running;Sampling;Scanning;simulation;skills;Small Interfering RNA;small molecule;software development;software infrastructure;Specific qualifier value;Specificity;Spectrum Analysis;success;Temperature;Therapeutic;therapeutic RNA;therapeutic siRNA;therapeutic target;tool;Torsion;Toxic effect;Training;training data;Translational Repression;ultraviolet;Vertebral column;Work

PROJECT_TITLE: Developing a nucleic acid force field with direct chemical perception for computational modeling of nucleic acid therapeutics


ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

PHR: Women Veterans who use VA healthcare face elevated risks of poor pregnancy outcomes compared to civilians due to higher rates of chronic medical and mental health conditions. Proactive planning and optimization of health prior to pregnancy can mitigate these risks; however, nearly 40% of pregnancies among Veterans are unplanned. Although national guidelines recommended routine assessment of women’s childbearing goals followed by tailored contraceptive and preconception counseling in primary care, these reproductive planning services are delivered infrequently in VA. This study is a multicenter pragmatic randomized controlled trial of “MyPath,” a novel web-based patient-facing decision support tool. MyPath is designed to be used by women Veterans prior to clinic visits to increase patient-centered reproductive planning discussions and facilitate high-quality decisions. If effective, this innovative, scalable intervention will improve delivery of guideline-recommended services as well as reproductive health outcomes in Veterans nationally.

PI_NAMEs: CALLEGARI, LISA SUSANNE (contact)

PROJECT_TERMS: Acceleration;Address;Adherence;adverse outcome;Age;aged;Appointment;automated text message;Behavior;Centers for Disease Control and Prevention (U.S.);child bearing;Chronic;Clinic;Clinic Visits;Clinical;cluster trial;Communication;comorbidity;comparison control;Conceptions;Conflict (Psychology);Contraceptive Agents;Contraceptive methods;Contraceptive Usage;cost;Counseling;Data;Data Collection;Decision Making;design;Economics;effective intervention;effectiveness evaluation;empowerment;Ensure;Evaluation;evidence base;Face;Family;Fertility;follow-up;future implementation;Goals;Guidelines;Health;Health behavior;Health Care Costs;Healthcare;Hybrids;implementation barriers;implementation facilitators;implementation process;improved;indexing;innovation;Intervention;intervention cost;Interview;Knowledge;Link;Low Birth Weight Infant;maternal depression;maternal outcome;Measures;Medical;Mental Health;Methodology;Methods;neonatal outcome;novel;Online Systems;Outcome;Outcome Assessment;patient oriented;patient-clinician communication;Patients;Personal Satisfaction;physical conditioning;Pilot Projects;pilot test;pragmatic randomized trial;preference;Pregnancy;Pregnancy Outcome;Premature Birth;Primary Care;primary care practice;primary care provider;primary care setting;primary care visit;primary outcome;Process;process evaluation;programs;Provider;Qualitative Methods;Randomized, Controlled Trials;Recommendation;Reporting;reproductive;Reproductive Behavior;Reproductive Health;Research;Research Design;research to practice;Risk;risk mitigation;secondary outcome;Self Efficacy;Services;shared decision making;Site;Social Well-Being;support tools;Surveys;Technology;Telephone;Testing;tool;Translational Research;treatment as usual;unintended pregnancy;urgent care provider;Veterans;Visit;web-based intervention;whole health;Woman;Women's Health;Women's Health Services;women's outcomes;Workload

PROJECT_TITLE: MyPath: A Patient-Centered Web-Based Intervention to Improve Reproductive Planning for Women Veterans

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Lung;Lung Cancer

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: PROJECT NARRATIVE Lung cancer remains the leading cause of death from cancer worldwide and current manual or robotic bronchoscopes provide limited or no direct sensor feedback. Hence, there is a need for safe, advanced sensing methods to monitor tissue-tool contact as well as tool position and shape during navigation, diagnosis, and therapy tasks. This supplement research will fulfill this clinical and technological need and will ultimately improve procedural safety, biopsy accuracy, and diagnostic yield of bronchoscopy by developing miniaturized soft optical sensors that can be integrated on the soft robotic bronchoscope developed in the parent grant. 1

PI_NAMEs: RUSSO, SHEILA  (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Academia;academic preparation;Academic Training;analog;Anatomy;Biological;biomaterial compatibility;Biopsy;Biopsy Specimen;Boston;Breast Cancer Patient;Bronchoscopes;Bronchoscopy;cancer diagnosis;cancer therapy;career;Cause of Death;Cessation of life;Clinical;clinical application;cohort;Colon Carcinoma;community building;Contusions;cost;cost effective;Cues;Dedications;design;Development;Diagnosis;Diagnostic;Diameter;doctoral student;Early Diagnosis;Educational workshop;Electromagnetics;Engineering;Environment;Event;Family suidae;Feedback;Forcep;Goals;Health;Hemorrhage;Hispanic;Human;Immune;improved;In Vitro;Industry;innovation;insight;Intervention;Lasers;Latino;Leadership;Location;Lung;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Manuals;manufacture;Measures;Mechanics;Medical;meetings;Mentors;Mentorship;Methods;Miniaturization;miniaturize;Monitor;multimodality;Needles;novel;operation;Operative Surgical Procedures;optical sensor;Optics;parent grant;Perforation;Peripheral;Persons;Positioning Attribute;Procedures;professor;Program Development;recruit;Research;Resolution;risk minimization;Robot;Robotics;Safety;sensor;sensor technology;Sensory;sensory feedback;Shapes;Structure;student mentoring;Students;Surface;Survival Rate;Systems Integration;Talents;Techniques;Technology;Testing;Therapeutic;Time;tissue trauma;Tissues;tool;Tube;Underrepresented Populations;Universities;Validation;Vision;Visual;visual feedback;Work

PROJECT_TITLE: Extending Reach, Accuracy, and Therapeutic Capabilities: A Soft Robot for Peripheral Early-Stage Lung Cancer


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;HIV/AIDS;Infectious Diseases;Mental Health;Mental Illness;Microbiome;Neurosciences

ORG_CITY: MIAMI

ORG_DEPT: MISCELLANEOUS

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative This randomized controlled trial will be the first to examine the efficacy of an evidence-based Cognitive- Behavioral Therapy for Adherence and Depression (CBT-AD) treatment for altering microbiome-gut-brain (MGB) axis pathways in depressed people with HIV (PWH) receiving effective anti-retroviral therapy. Leveraging an evidence-based CBT-AD treatment as an experimental probe will advance our basic understanding of the MGB axis pathways whereby decreasing depression potentiates alterations in key neurobehavioral substates relevant to depression in PWH. Examining MGB axis moderators and mediators using multi-level, high dimensional data will support efforts to identify subgroups of individuals who may be most responsive to CBT-AD as well as inform the development of a new generation of pharmacologic and behavioral treatments for depression targeting the MGB axis in PWH.

PI_NAMEs: CARRICO, ADAM WAYNE (contact);PAUL, ROBERT HARRIS

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Acute;acute infection;Amino Acids;antiretroviral therapy;Behavior Therapy;Behavioral;Brain;Catabolism;Central Nervous System;Clinical Research;Cognitive Therapy;Communication;Counseling;Depressed mood;depressive symptoms;Development;dysbiosis;efficacy evaluation;eligible participant;Enrollment;Epidemic;evidence base;Evidence based treatment;experience;Experimental Models;follow up assessment;Functional Magnetic Resonance Imaging;Gastrointestinal tract structure;Gene Expression;Generations;Genetic Transcription;Goals;gut dysbiosis;gut microbiome;gut-brain axis;HIV;HIV Infections;Immune;Immune system;Immunologic Markers;Immunologics;improved;Individual;Inflammatory;inhibitor;innovation;Integrase;Interoception;Leukocytes;Link;Measures;Mediator;Mental Depression;microbial;microbial products;microbiome;microbiome alteration;Modernization;multidimensional data;Negative Valence;neural;neural network;neurobehavioral;Neuroimmune;neuropsychiatric disorder;Neurosecretory Systems;Notification;Outcome;Participant;Pathogenesis;Pathway interactions;Peripheral;Persons;Pharmacological Treatment;Primary Care Physician;primary outcome;Psychoneuroimmunology;Psychosocial Assessment and Care;Psychosocial Factor;Randomized;Randomized, Controlled Trials;Regimen;Research;response;Rest;Rewards;Risk;Running;Serotonin;Signal Pathway;Signal Transduction;stem;Subgroup;System;therapy adherence;treatment research;Tryptophan;Unipolar Depression;Up-Regulation;Vagus nerve structure;Viral Load result;Waiting Lists

PROJECT_TITLE: Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Kidney Disease;Pediatric;Precision Medicine;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: LAY NARRATIVE MCD, FSGS, MN, and IgAN are rare glomerular diseases of the kidney that cause serious illness including kidney failure and high mortality, generating enormous individual and societal burden. CureGN has assembled nephrologists, researchers with expertise in different scientific disciplines, and patients in a consortium that maintains and analyzes a large, longitudinal observational data and biosamples like blood, urine and images of kidney biopsies. This initiative has developed a critical infrastructure that will advance our ability to study, classify, characterize, diagnose, and treat primary glomerular diseases of the kidney.

PI_NAMEs: DEREBAIL, VIMAL KUMAR;FALK, RONALD J (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Acceleration;Achievement;actionable mutation;Address;Adult;Advocacy;Affect;Ancillary Study;APOL1 gene;biobank;Biocompatible Materials;Biology;biopharmaceutical industry;Biopsy;Blood;career development;Child;Childhood;Classification;Clinic;Clinical;clinical center;Clinical Data;Clinical Research;cohort;Collaborations;Collection;Communication;Communities;community engagement;Consultations;Data;Data Collection;data collection methodology;Data Coordinating Center;Databases;Development;Diagnosis;digital pathology;Discipline;Disease;Disease remission;Educational workshop;Electronic Health Record;Emerging Technologies;Enrollment;Ensure;Epigenetic Process;Etiology;Focal and Segmental Glomerulosclerosis;follow-up;Formalin;Fostering;Funding;Funding Agency;Future;Genetic;genome sequencing;Goals;Grant;Health Technology;Heterogeneity;high risk;high standard;IGA Glomerulonephritis;Immunologics;improved;Individual;Industry;industry partner;Infrastructure;innovation;International;Investigation;kidney biopsy;Kidney Diseases;Kidney Failure;kidney imaging;Knowledge;Longitudinal, observational study;Medical Record Linkage;Membranous Glomerulonephritis;metabolomics;Methods;mHealth;Michigan;Mission;mobile application;Modernization;Morbidity - disease rate;mortality;multidisciplinary;multimodal data;Natural History;Nephrology;next generation;North Carolina;novel;observational cohort study;Observational Study;Outcome;Output;outreach;pandemic disease;Paraffin Embedding;Participant;participant retention;Pathogenesis;Pathology;patient advocacy group;Patient Care;patient engagement;Patient Outcomes Assessments;Patient Participation;Patients;Pattern;Pennsylvania;personalized care;Persons;Phase;Pilot Projects;Population;precision medicine;predict clinical outcome;Procedures;Process;Productivity;Professional Organizations;Prognosis;programs;prospective;Protocols documentation;Publications;Publishing;recruit;Renal glomerular disease;repository;Research;Research Personnel;risk variant;Role;sample collection;Sample Size;Science;Scientist;Services;Site;social;social health determinants;Standardization;Statistical Data Interpretation;Structure;Time;Tissue Embedding;tool;Training;transcriptome sequencing;Translational Research;treatment response;treatment strategy;Universities;Urine;Visit;whole genome;Work;working group

PROJECT_TITLE: CureGN-3: UNCPCC

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-6 (M1)]


ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

ORG_STATE: PA

PHR: Intervertebral disc degeneration is strongly implicated as a cause of low back pain. Current therapies address symptoms but do not restore native disc structure or function. Delivery of mesenchymal stem cells (MSCs) represents a highly translational therapeutic strategy; however MSC performance in vivo is limited due to low oxygen and nutrition. The overall objective of this project is establish the long term efficacy of an optimized MSC and hydrogel therapy for restoring disc structure and mechanical function, and alleviating symptoms, using a preclinical large animal model of disc degeneration.

PI_NAMEs: MAUCK, ROBERT L (contact)

PROJECT_TERMS: Accounting;active duty;Acute;Address;Adopted;Adult;Animal Model;Autologous;Award;Biochemical;Biomechanics;Biophysics;Bone Marrow;Cell Separation;Cell Therapy;Cells;Characteristics;Clinical;clinical application;clinical translation;Clinical Trials;clinically relevant;Custom;Dependence;Development;Diagnosis;disability;disc regeneration;donor stem cell;Exhibits;Exposure to;Extracellular Matrix;Functional Regeneration;Future;Goat;Harvest;Human;Human Characteristics;Hydrogels;Hypoxia;imaging biomarker;Implant;implantation;In Vitro;in vivo;Incidence;Injectable;Injections;Intervertebral disc structure;intervertebral disk degeneration;long term recovery;Low Back Pain;Mechanics;Mesenchymal Stem Cells;minimally invasive;Modeling;molecular marker;Molecular Profiling;monolayer;N-Cadherin;nucleus pulposus;Nutrient;nutrition;Operative Surgical Procedures;Outcome Measure;Oxygen;Pain;Pain Measurement;pain symptom;Patients;Performance;Phenotype;Physiological;Positioning Attribute;pre-clinical;preclinical efficacy;preconditioning;predictive signature;prevent;Production;Property;reduce symptoms;regeneration potential;regenerative;response;screening;service member;Signal Transduction;Source;Spinal Fusion;stem cell differentiation;stem cell survival;stem cell therapy;Stimulus;Stress;Structure;Surgical Replantation;Symptoms;Techniques;Therapeutic;Therapeutic Intervention;Time;Tissues;transcriptome;translational therapeutics;Veterans

PROJECT_TITLE: Bioactive injectable implants for functional intervertebral disc regeneration

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Immunization;Immunotherapy;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: HENNEPIN HEALTHCARE RESEARCH INSTITUTE

ORG_STATE: MN

PHR: PROJECT NARRATIVE Malaria, which is caused by Plasmodium parasites, remains a major global health problem with over 600,000 deaths annually worldwide. Our incomplete understanding of the mechanisms underlying the slow acquisition of immunity to malaria has hindered efforts to prevent and treat it. This project investigates the effects of an immune-modulatory therapy on the T cell, B cell, and antibody responses to Plasmodium infection and vaccination.

PI_NAMEs: BURRACK, KRISTINA STOERMER (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: acquired immunity;Adjuvant;Adoptive Transfer;Anti-malarial drug resistance;Antibodies;Antibody Formation;Antibody Response;Area;Attenuated;B cell differentiation;B-Lymphocytes;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Differentiation process;Cell Physiology;Cells;Cellular Immunity;Cessation of life;Clinical;Clinical Trials;Complex;conditional knockout;Country;cytokine;Data;design;Disease;Effector Cell;efficacy testing;experience;Exposure to;Flow Cytometry;Frequencies;Generations;Genetic;global health;Helper-Inducer T-Lymphocyte;Hepatocyte;Histology;Human;Humoral Immunities;Immune response;Immunity;immunomodulatory strategy;immunomodulatory therapies;Impairment;improved;Infection;Inflammation;Inflammatory Response;Insecticide Resistance;Interleukin-10;Interleukin-15;Knock-out;Knockout Mice;Knowledge;Liver;Location;Maintenance;Malaria;malaria infection;Malaria Vaccines;Mediating;Memory;Memory B-Lymphocyte;memory CD4 T lymphocyte;MHC Class II Genes;Modeling;Molecular;mouse model;Mus;Natural Killer Cells;novel;novel therapeutic intervention;Parasites;Pathologic;Pathway interactions;Peptide/MHC Complex;Persons;Phenotype;Plasmodium;Plasmodium berghei;Plasmodium vaccine;Predisposition;prevent;Process;Production;rational design;Reagent;response;Role;single-cell RNA sequencing;Sporozoite vaccine;Sporozoites;Structure of germinal center of lymph node;T cell response;T-Lymphocyte;Testing;therapy development;tissue resident memory T cell;transmission process;Vaccination;vaccination strategy;Vaccine Adjuvant;vaccine development;vaccine efficacy;vaccine immunogenicity;Vaccines;Work

PROJECT_TITLE: Enhancing T and B cell responses to Plasmodium infection and vaccination via IL-15

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The regulation of the inflammatory response is critical in normal physiological processes but also in acute and chronic inflammatory diseases. We are proposing to test and molecularly dissect the contribution of a repressive regulatory factor, which responds to heme, a molecule essential for life and a major component of blood and muscle tissue in macrophages, a cell type of the innate immune system. We will determine its role using cellular and animal models of inflammation which will provide a better understanding of the inflammatory response, and will support the designing of more rational and effective therapies.

PI_NAMEs: NAGY, LASZLO  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: 3-Dimensional;Acute;Affect;Animal Model;Architecture;ATAC-seq;BACH1 gene;Binding;Biological Assay;Blood;Bone Marrow Transplantation;BTB/POZ Domain;Catabolism;Cell Differentiation process;Cell model;cell type;Cells;Cellular Metabolic Process;Chemicals;ChIP-seq;Chromatin;chromatin remodeling;Chromatin Structure;chronic inflammatory disease;Complex;cytotoxic;Data;design;Development;DNA Binding;effective therapy;EGR2 gene;Enhancers;Ensure;epigenome;epigenomics;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic;Genetic Transcription;genome-wide;Genomic Segment;Genomics;Heme;heme a;Heterogeneity;Homeostasis;Homologous Gene;IL4 gene;Image;Immune;Immunohistochemistry;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Injury;Innate Immune System;innovative technologies;insight;intercellular communication;Kinetics;Knockout Mice;Life;Link;Macrophage;Mediator;Messenger RNA;Metabolic;Modality;Modeling;Molecular;Molecular Biology;mouse model;multiple omics;Muscle;muscle regeneration;Myelogenous;Myeloid Cells;novel;Pathway interactions;Phenotype;Physiological Processes;Play;Positioning Attribute;PPARG gene;promoter;Property;Proteomics;Protocols documentation;regeneration model;regenerative;regenerative tissue;Regulation;Repression;Resolution;RNA;RNA Polymerase II;Role;segregation;Shapes;Signal Transduction;single molecule;Site;Specific qualifier value;Stimulus;Testing;tissue repair;Tissues;tool;transcription factor;Transcription Repressor;Transcriptional Activation;transcriptomics;Work

PROJECT_TITLE: BACH1 as a novel pioneer repressor in macrophages: impact on homeostasis and inflammation

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Kidney Disease;Patient Safety;Prevention;Transplantation

ORG_CITY: Portland

ORG_NAME: ARONORA, INC.

ORG_STATE: OR

PHR: Project Narrative There is a critical unmet medical need for safe blood thinning drugs that do not cause bleeding. This unmet need is especially important in kidney failure patients who require chronic vascular access to perform life- saving kidney replacement therapy via vascular access sites that are highly prone to blood clots and occlusion. The proposed research addresses this critical need by continuing the clinical development of a unique drug candidate, AB023 (xisomab 3G3), which has been shown in primate studies and early human trials to potently inhibit blood clot formation without bleeding side-effects, and therefore has the potential to safely prevent vascular access clotting and failure.

PI_NAMEs: LORENTZ, CHRISTINA U (contact);TUCKER, ERIK IAN

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: Achievement;Acute;Addendum;Address;Adverse event;African American;Agreement;American Society of Hematology;Anticoagulants;Anticoagulation;Arteriovenous fistula;arteriovenous graft;Authorization documentation;Award;Binding;Biotechnology;Black race;Blood;Blood coagulation;Blood Vessels;C-reactive protein;Cardiovascular system;Catheters;Chemistry;Chronic;Clinical;Clinical Data;clinical development;Clinical Trials;Coagulation Process;Complex;Complication;Contact Inhibition;Data;Development;Dialysis procedure;Dose;Double-Blind Method;drug candidate;Drug Kinetics;Drug toxicity;efficacy outcomes;efficacy study;efficacy trial;End stage renal failure;Evaluation;Event;Exposure to;Factor XI;Factor XII;Factor XII Deficiency;Failure;Feedback;Female;Fibrinolytic Agents;Freeze Drying;Goals;Guidelines;health care disparity;Hemodialysis;Hemorrhage;Hemostatic Agents;Human;Hyperplasia;Implant;Incidence;Industry;Infection;Inflammation;Inflammatory;inhibitor;innovation;Interruption;Intervention;Kidney Failure;Lead;Legal patent;Life;Longevity;male;Marketing;Measures;Medical;meetings;Morbidity - disease rate;mortality;neutralizing antibody;No-Observed-Adverse-Effect Level;novel strategies;Outcome;Outcome Measure;Pathway interactions;patient population;Patients;Pharmaceutical Preparations;Pharmacodynamics;Pharmacologic Substance;Pharmacology;Phase;Phase II Clinical Trials;placebo controlled study;Placebos;Plasma;Population;preclinical safety;prevent;Primates;Procedures;product development;Prosthesis;Randomized;Rattus;Recommendation;Recovery;Regimen;Renal Replacement Therapy;Research;Risk;Safety;safety study;Secure;Serum;side effect;Site;Small Business Innovation Research Grant;Sprague-Dawley Rats;Stenosis;success;System;targeted treatment;Therapeutic;Therapeutic antibodies;Thrombin;Thrombosis;thrombotic;Thrombus;Toxic effect;treatment duration;Venous

PROJECT_TITLE: Contact Pathway Inhibitor to Prevent Vascular Access Failure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(10)B]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Data Science;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Narrative To help children with language delays and disorders, we need to understand the basic facts about language learning. The CHILDES project does this by allowing rapid searching for developmental patterns across a large database of transcripts from children learning language. We also provide tools for automatic speech recognition and automatic annotation of phonological and grammatical patterns.

PI_NAMEs: MACWHINNEY, BRIAN  (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: analytical method;automated speech recognition;Charge;Child;Child Language;comparison group;Computer Analysis;Computer Assisted;computerized tools;Data;Data Analyses;data exchange system;data format;Data Science;Data Set;Databases;Dependence;Development;Educational workshop;Empirical Research;Genetic Transcription;Home;improved;innovation;Internet;Language;Language Delays;Language Development;Language Disorders;Learning;Linguistics;Link;Manuals;Measures;media use;Metadata;Methodology;Methods;Morphology;Online Systems;open data;Pattern;Phase;phonology;programs;Published Comment;Publishing;Pythons;Research;Research Personnel;Series;sound;Structure;symposium;syntax;System;Techniques;tool;Transcript;United States National Institutes of Health;web platform;web services;word learning;Work

PROJECT_TITLE: Computational analysis of child language transcript data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-H (02)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Eczema / Atopic Dermatitis;Health Services;Machine Learning and Artificial Intelligence;Pediatric

ORG_DEPT: DERMATOLOGY

PHR: PROJECT NARRATIVE Atopic dermatitis, or eczema, is the most common chronic skin disease in children and the leading cause of skin disease burden worldwide. While highly efficacious, targeted systemic therapies have recently emerged for the treatment of moderate-to-severe atopic dermatitis, there remain critical gaps in our knowledge about their long-term effectiveness and safety in pediatric populations. This project seeks to set the stage for comparative effectiveness research in pediatric atopic dermatitis by developing and testing the tools needed to conduct future pragmatic trials and multi-center observational studies in routine care settings, with the ultimate goal of optimizing treatment selection for young patients and their families.

PI_NAMEs: WAN, JOY  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: 18 year old;Adolescent;Adverse effects;Affect;Atopic Dermatitis;Black Box;burden of illness;Cardiovascular system;Cessation of life;Child;Childhood;Chronic;Classification;Clinical Pathways;Clinical Research;Code;cohort;comparative effectiveness;Comparative Effectiveness Research;comparative safety;compare effectiveness;computable phenotypes;Data;Data Element;data modeling;Decision Making;design;Diagnostic;Disease;disorder control;Drug Prescriptions;Eczema;Effectiveness;effectiveness evaluation;electronic health data;Electronic Health Record;Emotional;Ensure;Event;evidence base;Family;Future;Goals;Growth;Head;Health system;immunomodulatory therapies;immunoregulation;Individual;Infection;inhibitor;Janus kinase;kinase inhibitor;Knowledge;Laboratories;Machine Learning;Malignant Neoplasms;Manuals;Methods;Methotrexate;Monoclonal Antibodies;Morbidity - disease rate;novel;Observational Study;older adult;optimal treatments;Oral;Outcomes Research;Patient-Focused Outcomes;Patients;pediatric patients;Pharmaceutical Preparations;Population;pragmatic trial;Provider;randomized trial;Research;research study;routine care;Safety;Selection for Treatments;skin disorder;social;structured data;Systemic Therapy;Testing;Therapeutic;tool;Topical Corticosteroids;treatment and outcome;treatment group;treatment optimization;trial design;venous thromboembolism

PROJECT_TITLE: Systemic Treatments and Outcomes for Pediatric Atopic Dermatitis: Setting the Stage for Comparative Effectiveness Research

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Hematology;Prevention

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE This proposal promotes public health because although many men and women will experience venous thromboembolism as they age, existing treatment strategies do not incorporate their experiences, goals and values and carry important risks. Understanding older adults’ priorities for venous thromboembolism decision- making, examining the real-world outcomes of older adults with venous thromboembolism, and creating an aging-centered estimate of bleeding risk on long-term anticoagulation are all essential to develop a decision aid that facilitates individualized treatment decision-making. Thus, this project is consistent with the National Institute on Aging’s mission to develop and advance knowledge to improve the prevention, diagnosis, and treatment of common diseases and conditions of aging in vulnerable patient populations.

PI_NAMEs: PARKS, ANNA L (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adult;Affect;Age;Aging;aging related;aging related disease;Anticoagulants;Anticoagulation;Award;Benefits and Risks;Caregivers;Caring;Characteristics;Clinical;clinical practice;clinical risk;Clinical Trials;Clinical Trials Design;Cognition;cohort;common treatment;Communication;Data;Data Set;Data Sources;Decision Aid;Decision Making;design;Development;Diagnosis;Disabling;Disease;Dose;effectiveness testing;Elderly;Ensure;Event;evidence base;Exclusion;experience;Focus Groups;Foundations;Frail Elderly;frailty;Functional impairment;Future;Geriatrics;Goals;Grant;Guidelines;Health;Hematological Disease;Hematology;Hemorrhage;Heterogeneity;high risk;human old age (65+);improved;individualized medicine;insight;Intervention;Interview;Knowledge;Life;Life Expectancy;men;Mentors;Mentorship;Methods;Mission;Modeling;Morbidity - disease rate;mortality;multidisciplinary;National Institute on Aging;neglect;Non-Malignant;older adult;older patient;Outcome;Outcome Measure;outcome prediction;patient oriented;Patient Outcomes Assessments;patient population;Patient-Focused Outcomes;Patients;Personal Satisfaction;personalized decision;Population;population based;Population Database;practice setting;prevent;Prevention;Public Health;Qualitative Methods;Quality of Care;Quality of life;Recommendation;Recurrence;Research;Research Methodology;Research Personnel;Risk;Risk Estimate;risk prediction model;Shapes;skills;Structure;Syndrome;Testing;thrombolysis;Training;treatment strategy;United States Department of Veterans Affairs;Universities;user centered design;Utah;venous thromboembolism;Vertebral column;Woman;Work

PROJECT_TITLE: Advancing patient-centered decision making in older adults with venous thromboembolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-6 (M1)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Bipolar Disorder;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project narrative. Bipolar Disorder, defined by a history of mania/ hypomania (periods of elevated mood and energy), and characterized by heightened sensitivity to rewards and higher than normal levels of often risky, approach-oriented decision-making and behavior, is common, with harmful effects on health, but current treatments often do not work and can have unpleasant or intolerable side effects; therefore, better treatments are needed. Our overarching hypothesis is that mania/hypomania results from abnormally high activity and high levels of dopamine release in the brain reward network (RNet) but abnormally low (or no change in) levels of activity and dopamine release in the brain central executive network (CEN). We will test this hypothesis with multimodal neuroimaging studies measuring activity and dopamine release in the RNet and CEN; and relationships among these measures and indices of approach-oriented behavior, and mania/hypomania, to help develop new treatments that specifically target the RNet and/or the CEN, have fewer side effects, and more effectively reduce mania/hypomania and the likelihood of its recurrence in people with Bipolar Disorder.

PI_NAMEs: NARENDRAN, RAJESH ;PHILLIPS, MARY LOUISE (contact);SARPAL, DEEPAK K

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Adult;Age;Amphetamines;Behavior;Binding;Bipolar Disorder;Brain;Characteristics;Corpus striatum structure;Decision Making;Development;Disabling;Dopamine;Dorsal;Etiology;Expectancy;experience;Female;Functional Magnetic Resonance Imaging;Future;Gender;Goals;Health;high reward;hypomania;Image;Impaired health;indexing;Left;Link;Manic;Measures;Midbrain structure;Moods;multimodal neuroimaging;neural network;neurobiological mechanism;neuromelanin;Noise;Oral;Outcome;pars compacta;Participant;Persons;Positron-Emission Tomography;Predisposition;Prefrontal Cortex;Probability;Proxy;Psychoses;psychosocial;psychotic;Raclopride;receptor;Recording of previous events;recruit;Recurrence;Relapse;reward expectancy;Rewards;Severities;side effect;Substantia nigra structure;Symptoms;targeted treatment;Testing;Time;Ventral Striatum;Ventral Tegmental Area;Work

PROJECT_TITLE: Linking mania/hypomania with abnormal reward expectancy- and approach-related neural network activity and dopamine release

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Services;Mental Health;Primary Health Care

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: NARRATIVE The goal of the Ensuring Quality in Psychological Support and Mental Health Helping Skill–Service User version (EQUIP-SU) project is to develop a quality assessment tool that can be completed by people with lived experience of mental health conditions to rate the services they receive. Using a co-creation approach, the quality assessment tool will be developed with people with lived experience (the demand side of mental health services) and health system managers and policy makers (the supply side of mental health services). Successful development of a quality assessment tool will enable people using mental health services to provide feedback to managers and policy makers to improve decision making for strengthening mental health care.

PI_NAMEs: KOHRT, BRANDON ALAN (contact)

PROGRAM_OFFICER_NAME: CUBILLOS, LEONARDO

PROJECT_TERMS: Address;Advocacy;Assessment tool;beneficiary;career;Caregivers;Caring;Client satisfaction;Clinical;clinical encounter;Communication;community setting;Competence;Consumption;Country;Data;data visualization;Decision Making;design;Development;education resources;Educational Materials;Educational workshop;Ensure;Evaluation;evidence base;experience;Feedback;Fostering;Funding;global health;Goals;health care delivery;Health care facility;Health Care Rationing;health care service;health equity;health management;health service use;Health Services Research;Health system;Healthcare Systems;human centered design;implementation strategy;improved;Infrastructure;Intention;International;Intervention;Interview;Lead;Liberia;Lived experience;low and middle-income countries;Management Information Systems;Measurement;member;Mental Health;mental health center;Mental Health Services;Mentors;Nepal;Outpatients;Patient Education;Patients;peer networks;Persons;Pharmaceutical Preparations;pilot test;Policy Maker;Population;Primary Care;primary care setting;Process;programs;Provider;provider behavior;psychologic;psychosocial;Quality Indicator;Quality of Care;Records;Registries;Research;Research Personnel;research study;Resource-limited setting;Resources;Risk;satisfaction;screening;Series;service delivery;service providers;service utilization;Services;Side;Site;skills;Specialist;Standardization;suicidal risk;Surveys;Testing;Theory of Change;tool;tool development;Training;Treatment outcome;UNICEF;Universities;USAID;Washington;webinar;Work;World Health Organization

PROJECT_TITLE: Ensuring Quality in Psychological and Mental Health Services - Service User Quality Assessment EQUIP-SU

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (04)]


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Serum biomarker measurements have been widely used as diagnostic/prognostic indicators, but many markers are not sufficiently sensitive and/or specific to accurately identify the disease state. This project aims to build a machine perception nanosensor array platform technology to detect whole disease fingerprints from patient biofluids. The sensor technology will be optimized and validated for pancreatic cancer to improve diagnoses and biomarker discovery processes.

PI_NAMEs: KIM, MIJIN  (contact)

PROGRAM_OFFICER_NAME: MULVANEY, SHAWN PATRICK

PROJECT_TERMS: Acceleration;Algorithms;artificial neural network;Award;Binding;Biological Markers;biomarker discovery;biomarker identification;CA-19-9 Antigen;Cancer Detection;Cancer Etiology;Carbon Nanotubes;Cessation of life;Classification;Clinical;Collection;Color;Data;Data Set;Detection;Diagnosis;Diagnostic;Disease;Disease Progression;Distant;DNA;DNA Library;Drops;Early Diagnosis;Early identification;Event;experimental study;Fingerprint;high risk;Immunoassay;improved;improved outcome;Individual;innovation;large datasets;Libraries;Machine Learning;machine learning algorithm;machine learning model;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Mentors;model development;Modeling;Molecular;molecular marker;mortality;nanosensors;Neoplasm Metastasis;Outcome;Pancreas;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;Patients;Perception;potential biomarker;Principal Component Analysis;Process;process optimization;prognostic indicator;Property;prospective;protein biomarkers;Proteins;Proteomics;random forest;Recurrence;response;Sampling;screening;Sensitivity and Specificity;sensor;sensor technology;Serum;Serum Markers;Site;Source;Specificity;support vector machine;Survival Rate;Technology;technology platform;temporal measurement;Testing;Training;United States;validation studies;Variant;Work

PROJECT_TITLE: Machine Perception Nanosensor Array Platform to Capture Whole Disease Fingerprints of Early Stage Pancreatic Cancer

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Patient Safety;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: Project Narrative The proposed work will address key knowledge gaps about the clinical, geriatric, and ethical dimensions of need for hospitalized incarcerated older adults. We will leverage a unique dataset from a 5-state hospital network, spanning 25 years and thousands of hospital admissions, to define prevalence and trends in factors such as age, delirium, and advance directive completion. We will also conduct interviews to characterize the experience of hospitalization for an incarcerated older adult from multiple vantage points: patient, family, correctional officer, and bedside nurse. Finally, we will evaluate prevalence and contents of state and federal policies pertinent to the hospital care of older adults.

PI_NAMEs: DEMARTINO, ERIN S (contact)

PROJECT_TERMS: Acute;acute care;Adult;advanced directive;Adverse event;Advisory Committees;Affect;Age;aged;Aging;Alzheimer's disease related dementia;Area;Award;Behavior;Bioethics;Cardiovascular Diseases;career development;Caring;Characteristics;Chronic;Clinic;Clinical;Clinical Data;Communities;comorbidity;Complex;Constitution;Correctional Institutions;cost;court;COVID-19;Critical Care;Data;Data Set;Decision Making;Delirium;Dementia;Democracy;Development;Development Plans;Dimensions;early onset;Education;Elderly;end of life care;Epidemiology;Ethicists;Ethics;Ethics Consultation;Ethnic Origin;Ethnic Population;expectation;experience;Face;Family;Family member;federal policy;Funding;Geriatrics;Goals;Health;health care availability;Health Policy;Health Services Accessibility;Health Status;Healthcare;High Prevalence;hospital care;hospital readmission;hospital utilization;Hospitalization;Hospitals;Housing;Imprisonment;improved;Incidence;Individual;insight;Instruction;Internal Medicine;International;Intervention;Interview;Knowledge;leadership development;lens;Life;Litigation;Lung;Malignant Neoplasms;marginalization;Medical;medical vulnerability;Medicine;Mentors;Mentorship;Methodology;Methods;Misinformation;mortality;multiple chronic conditions;Needs Assessment;Nurses;older adult;Onset of illness;Outcome;Patient Care;Patient Rights;Patient Transfer;Patients;pediatric trauma;peer;Persons;Policies;Policy Analysis;Policy Research;Population;Positioning Attribute;Prevalence;prison population;Prisons;Privacy;privacy protection;programs;Publications;Qualitative Methods;Race;racial minority population;Recording of previous events;Records;recruit;Regulation;Research;research and development;Research Ethics;Research Methodology;Research Personnel;Resources;Risk;Scholarship;social stigma;State Hospitals;statistics;Statutes and Laws;Structure;surrogate decision making;System;Testing;Time;Time trend;Training;Training Programs;Translating;trend;Triage;Uncertainty;United States;violence exposure;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Assessing Needs and Advancing Dignity-Conserving Care for Hospitalized, Incarcerated Older Adults: Clinical Data, Patient Experience, and Policy Evaluation


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Glioblastoma (GBM) is a uniformly fatal cancer, partially due to a highly immunosuppressive microenvironment caused by the adenosine (ADO) metabolism and signaling pathway. We will determine if antibodies or small molecules inhibiting CD39 and CD73 ectonucleotidases, adenosine receptor, or novel oncolytic herpes simplex virus (oHSV) vectors expressing adenosine degrading enzymes (ADEs), or a combination can inhibit the ADO pathway in a novel panel of mouse and human glioblastoma stem-like cells (GSCs) and immune cells in vitro. Finally, we hypothesize that the combination of intratumoral oHSV expressing an ADE plus systemic inhibitors of the ADO pathway will synergistically improve GBM treatment efficacy in vivo.

PI_NAMEs: MARTUZA, ROBERT L (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: 3-Dimensional;adaptive immune response;adaptive immunity;Adenosine;adenosine deaminase;Adenosine Kinase;ADORA2A gene;angiogenesis;Angiogenesis Inhibitors;Antibodies;Binding;Brain;Brain Neoplasms;Cell Line;Cell membrane;Cells;Clinic;Coculture Techniques;complement C2a;Cytotoxic T-Lymphocytes;Development;ecto-nucleotidase;Enzymes;Exhibits;extracellular;Extracellular Space;Genetic Engineering;Glioblastoma;HSV vector;Human;Hypoxia;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immunocompetent;Immunologic Stimulation;Immunosuppression;Immunotherapeutic agent;immunotherapeutic virotherapy;improved;In Vitro;in vivo;Individual;inhibitor;Innate Immune Response;Interleukin-12;Laboratories;Light;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Metabolism;Mus;Natural Immunity;Natural Killer Cells;neoplastic cell;Normal tissue morphology;novel;Nucleoside Transporter;Oncolytic;oncolytic herpes simplex virus;Oncolytic viruses;Pathway interactions;Patients;Purinergic P1 Receptors;Radiation therapy;receptor;Regulatory T-Lymphocyte;Series;Signal Pathway;Signal Transduction;Simplexvirus;small molecule;Source;stem-like cell;stemness;success;Systemic Therapy;temozolomide;Testing;Therapeutic Trials;trait;Translations;Treatment Efficacy;tumor;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions

PROJECT_TITLE: Oncolytic HSV Immunovirotherapy for brain tumors

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: During stroke, cancer, and other traumatic situations, many cells undergo necrosis and apoptosis after injury; the swift removal of these cells prevents tissue injury, inflammatory responses, and auto-immune responses, clears the wounded area, and promotes tissue repair. Necrosis is closely associated with neurodegeneration. Understanding the mechanisms controlling the recognition and engulfment of necrotic neurons will have important therapeutic implications in fighting chronic inflammatory and auto-immune diseases, and in treating neurodegenerative diseases and stroke.

PI_NAMEs: ZHOU, ZHENG  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Alzheimer's Disease;Animals;Apoptosis;Apoptotic;ATP-Binding Cassette Transporters;Autoimmune Diseases;Autoimmune Responses;Axon;Caenorhabditis elegans;Cell membrane;Cell Separation;cell suicide;Cells;chronic inflammatory disease;Cytoplasm;Development;dominant genetic mutation;Eating;Endoplasmic Reticulum;Event;Evolution;Excision;fighting;Genes;Genetic Screening;Goals;graduate student;Homeostasis;Homologous Gene;Human;Induced Mutation;Inflammatory Response;Injury;Ion Channel Protein;Learning;Life;lipid transfer protein;Lipids;Malignant Neoplasms;Mediating;Microglia;model organism;Molecular;mutant;Necrosis;Nematoda;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;Outcome;Pathway interactions;Phagocytes;Phagocytosis;Phosphatidylserines;phospholipid scramblase;Physiological;Prealbumin;prevent;Process;Protein Family;Proteins;Recovery;repaired;response;Role;Signal Transduction;Stroke;Surface;Synapses;Therapeutic;tissue injury;tissue repair;Touch sensation;Translating;Wounded area

PROJECT_TITLE: How are necrotic neurons recognized by their phagocytes


NIH_SPENDING_CATS: Antimicrobial Resistance;Genetics;Infectious Diseases;Malaria;Natural Products;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE This research addresses the critical issue of artemisinin resistance in Plasmodium falciparum parasites, which has emerged in east Africa, and which threatens antimalarial treatment and control efforts across sub-Saharan Africa. Our project leverages recent discoveries from genetic crosses to define the multigenic basis of artemisinin resistance and identify genetic markers of resistance to quinine, an alternative first-line drug for severe malaria. We will also assess the resistance risks of currently used partner drugs and identify which of the candidate therapeutics currently in clinical trials have the lowest risk of succumbing to parasite resistance.

PI_NAMEs: FIDOCK, DAVID A (contact)

PROJECT_TERMS: Acute;Address;Africa;Africa South of the Sahara;African;Animal Model;Anti-malarials;Appearance;Artemisinins;artesunate;asexual;Asian;base editing;benflumetol;Binding;Biological Assay;Blood;Cambodian;Chloroquine resistance;Chromosomes;Clinical;Clinical Trials;Coculture Techniques;Combined Modality Therapy;Complex;coronin protein;cost;Country;CRISPR/Cas technology;Data;Death Rate;Development;DNA biosynthesis;Doctor of Philosophy;Drug usage;drug-sensitive;Engineering;experimental study;Falciparum Malaria;first-in-human;fitness;Future;Genes;Genetic;Genetic Crosses;Genetic Determinism;Genetic Markers;Genome;Geographic Locations;Goals;Human;improved;In Vitro;in vivo;innovation;insight;Intravenous;knock-down;Knowledge;Malaria;Maps;Measures;Mediating;Mediator;Metabolic Clearance Rate;molecular marker;Morbidity - disease rate;mortality;Multi-Drug Resistance;mutant;Mutation;novel;Parasite resistance;Parasites;Parents;Patients;Pharmaceutical Preparations;Plasmodium falciparum;Point Mutation;Population;Predisposition;pressure;Proliferating;Protein Isoforms;pyronaridine;Quinine;Recombinants;Refractory;Reporting;Research;Resistance;resistant Plasmodium falciparum;resistant strain;Risk;Role;Southeastern Asia;Study models;Testing;Therapeutic;therapeutic candidate;therapy resistant;Time;Transcriptional Regulation;Treatment Failure;Uganda

PROJECT_TITLE: Defining the complex genetic basis of Plasmodium falciparum resistance to artemisinin and quinine and identifying resistance-refractory therapeutics

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Obesity;Prevention;Social Determinants of Health

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: PROJECT NARRATIVE Neglect of the Jackson, MS, water system has led to widespread water contamination in recent decades and potential downstream health effects. Many toxicants present in a contaminated water supply can contribute to cardiovascular risk via high blood pressure, diabetes, and obesity. We use innovative methods to quantify water exposures over 20 years for participants in the Jackson Heart Study and test their association with key cardiovascular and metabolic outcomes to inform policy interventions to reduce the impact of the water crisis on cardiovascular health.

PI_NAMEs: CARSON, APRIL P (contact);NAYOR, MATTHEW G.;NIGRA, ANNE E;SHAH, RAVI

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Acids;Address;Adult;African American;Air Pollution;Arsenic;Biochemical;Bioinformatics;Blood;Blood Pressure;Body mass index;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Chemicals;Chronic;Clinical;cohort;Communities;Consent;contaminated water;coronary calcium scoring;County;Data;Death Rate;design;Deterioration;Development;Diabetes Mellitus;Disease Outcome;disease phenotype;Disinfectants;Disinfection;Environmental Exposure;Epidemiology;epidemiology study;Ethnic Origin;experience;Exposure to;fasting plasma glucose;Fatty acid glycerol esters;Funding;Furuncles;Future;Geographic Locations;Health;health disparity;Heart failure;Hepatic;high risk;Hypertension;Immune response;improved;Individual;Inductively Coupled Plasma Mass Spectrometry;Inequity;Infrastructure;innovation;Insulin Resistance;Intervention;Jackson Heart Study;Lead;Link;Maintenance;marginalized community;Mass Fragmentography;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolism;metabolomics;Metals;Methods;minority communities;Mississippi;Molecular;Monitor;National Heart, Lung, and Blood Institute;National Institute on Minority Health and Health Disparities;neglect;novel;Obesity;Outcome;Participant;Phenotype;Plastics;Policies;policy implication;Poly-fluoroalkyl substances;Population;Preparation;Prevention;prospective;Prospective, cohort study;Race;Radioisotopes;Records;Research Personnel;Resources;response;Risk;Risk Factors;Seasons;social determinants;sociodemographics;socioeconomics;Source;Stroke;System;Techniques;Testing;Time;toxicant;Toxicant exposure;Translating;Triglycerides;Trihalomethanes;United States National Institutes of Health;Visceral;Water;Water Pollutants;water quality;Water Supply;water testing

PROJECT_TITLE: Water Contaminants and Cardiovascular Risk:  the Jackson Heart Study

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE The scale and scope of scientific collaborations in the Human Islet Research Network (HIRN) bring together extraordinary resources to solve complex problems in type 1 diabetes (T1D). To capitalize on this initiative, extensive efforts are required to coordinate, communicate, and catalyze research effectively. This proposal to renew the Human Islet Research Enhancement Center (HIREC) provides the infrastructure and environment needed to accelerate progress and success in HIRN, transforming discoveries into strategies that prevent and/or treat T1D.

PI_NAMEs: KADDIS, JOHN S. (contact);NILAND, JOYCE CAROL

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: Acceleration;Address;advanced disease;Algorithms;Area;Award;Beta Cell;big biomedical data;Bioinformatics;Biometry;career development;Cities;Collaborations;collaborative environment;Communication;Communities;community engagement;Complex;Computational Biology;Country;Data;data centers;data reuse;Data Science;data sharing;Databases;Decision Making;Development;Diabetes Mellitus;diabetes pathogenesis;Dimensions;Disease;Education;effectiveness measure;Emerging Technologies;empowerment;Engineering;Environment;experience;FAIR principles;Feedback;Funding;Future;Goals;Human;improved;Information Networks;Infrastructure;innovation;Institution;Insulin-Dependent Diabetes Mellitus;interest;Internet;Investments;islet;knowledgebase;Learning;Manuals;Measures;meetings;Metabolism;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Occupations;operation;outreach;Pancreas;Pathogenesis;Persons;Positioning Attribute;preservation;prevent;Prevention strategy;Principal Investigator;Productivity;programs;Qualifying;Research;Research Institute;Research Personnel;research study;Resource Sharing;Resources;Sampling;satisfaction;Science;Scientist;Semantics;Services;software development;success;Surveys;System;Technology;tool;training opportunity;treatment strategy;Trust;user-friendly;Videoconferencing

PROJECT_TITLE: Renewal of the Human Islet Research Enhancement Center (HIREC) for the Type-1-Diabetes-Focused Human Islet Research Network (HIRN).

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-9 (M1)]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: The overall goal of this project is to translate a laboratory-based apparatus and method into a stand-alone BreEStim device and to validate its clinical efficacy and safety for neuropathic pain management in people after spinal cord injury (SCI) in a single-center randomized controlled clinical trial. At the completion of this project, we will be able to provide evidence that the BreEStim device is safe and effective for chronic neuropathic pain management in patients after spinal cord injury.

PI_NAMEs: LI, SHENG  (contact)

PROGRAM_OFFICER_NAME: HUDAK, ERIC MICHAEL

PROJECT_TERMS: Absence of pain sensation;Agreement;Air Movements;Analgesics;Breathing;Cephalic;Certification;chronic neuropathic pain;Clinical;clinical efficacy;cohort;commercialization;community advisory board;Cutaneous;desensitization;design;Device Designs;Device or Instrument Development;Devices;Dose;effective intervention;Effectiveness;efficacy evaluation;efficacy trial;Electric Stimulation;Electromagnetics;Ethics;experience;Feedback;follow-up;Future;Goals;Health;heart rate variability;improved;Individual;industry partner;Inhalation;innovation;Institutional Review Boards;Intervention;Laboratories;Letters;Marketing;Measurement;Medical;Medical Device;Methods;Multi-Institutional Clinical Trial;Multicenter Trials;neuroregulation;Nonpharmacologic Therapy;novel;Outcome;Pain management;pain patient;painful neuropathy;Pathway interactions;Patients;Performance;Peripheral;Peripheral Nerves;Persons;Phase;Process;product development;prototype;Quality of life;Randomized;Randomized Controlled Clinical Trials;Regulatory Pathway;Rehabilitation Outcome;Research;research clinical testing;Safety;satisfaction;sensor;Series;Signal Transduction;Source;Spinal cord injury;Stimulus;System;Techniques;Technology;Testing;Texas;Time;Translating;Translations;trial design;Universities;Update;usability;Validation;Visit;Weight;Work

PROJECT_TITLE: An innovative device for management of neuropathic pain after spinal cord injury

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The proposed research will project will assess the usability, acceptability, and feasibility of remote monitoring technologies for supporting aging-in-place for rural low-income, African-Americans and their care partners. Study findings will contribute notably to the further development of innovative, connected, multi-sensor remote monitoring systems that can facilitate the activities of daily living of African Americans living with ADRD. Combining this technological support system with other services may increase the likelihood that African Americans living with ADRD can age-in-place while reducing caregiver burden.

PI_NAMEs: OWENS, OTIS LASHAUN (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Activities of Daily Living;Address;Affect;African American;African American population;aging in place;Alzheimer's Disease;Alzheimer's disease related dementia;Attitude;Behavior;Businesses;career development;Caregiver Burden;Caring;Chronic Disease;college;commercialization;Communication;Communities;Community Healthcare;Computer software;cost;Data;Data Analytics;Dementia;Dependence;Development;Development Plans;Diabetes Mellitus;digital technology;Disparity;Doctor of Philosophy;Effectiveness;Entrepreneurship;Environment;evidence base;experience;falls;Family;Family member;Friends;Funding;Goals;Grant;Growth;Health;health care availability;Health care facility;Health Personnel;Healthcare;healthy aging;Home;Hour;Hypertension;Immersion;Incidence;Income;Individual;Industry;innovation;Institutionalized Persons;instrumental activity of daily living;Intervention;K-Series Research Career Programs;Knowledge;Life Experience;Long-Term Care;Long-Term Care for Elderly;Low income;Medicaid;medical specialties;Medication Management;Mental Health;Mentors;mid-career faculty;Monitor;older adult;Oregon;Outcome;Persons;Pharmaceutical Preparations;physical conditioning;Population;Poverty;Prevalence;pro-aging;programs;Readiness;remote monitoring;remote sensor;remote technology;Research;Research Methodology;Research Personnel;Research Project Grants;Research Support;Risk Factors;Rural;rural African American;rural residence;rural setting;Science;sensor;Services;skills;Small Business Innovation Research Grant;Social Work;socioeconomics;South Carolina;stem;Structural Racism;success;Support System;System;Target Populations;Technology;Time;Training;Training Activity;Training Programs;translational approach;translational research program;translational scientist;trend;Universities;usability;Visualization

PROJECT_TITLE: Home-based Digital Technologies: A Translational Approach to Support Aging-in-Place for Rural African-Americans with Alzheimer’s Disease and their Care Partners

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Estrogen;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Women's Health Research

ORG_CITY: BRYN MAWR

ORG_NAME: BRYN MAWR COLLEGE

PHR: Project Narrative Women are twice as likely to suffer from stress-related psychiatric disorders, such as post-traumatic stress disorder (PTSD) and depression, however, the neurobiological basis underlying this sex difference is unknown. The proposed research could provide evidence demonstrating how the neuropeptides orexins contribute to sex differences in stress and cognition and the mechanism behind sex differences in the orexin system. This project will have immediate implications for treatment, as orexin antagonists are currently used to treat insomnia; given the broad effects of orexins, targeting orexins may treat a broad range of psychiatric symptoms in a sex-specific manner.

PI_NAMEs: GRAFE, LAURA  (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Adult;Animals;antagonist;Area;Arousal;associated symptom;Autopsy;Behavior;Binding;Biological;biological adaptation to stress;Biological Assay;Brain;Clinical;Cognition;Cognitive;Cognitive deficits;cognitive function;Coupled;Data;Disparity;Dose;Eating;Emotional;Enzyme-Linked Immunosorbent Assay;Estrogen Receptors;Estrogens;Exhibits;FDA approved;Female;Fiber;flexibility;Future;Gonadal Hormones;GPER gene;Guidelines;habituation;hypocretin;Immunofluorescence Immunologic;Impaired cognition;Impairment;improved;Individual Differences;individualized medicine;Lead;male;Measures;Mediating;Memory;men;Mental Depression;Mental disorders;Mus;neural;Neurobiology;Neurons;Neuropeptides;orexin B receptor;Patients;Performance;Photometry;Plasma;Population;Post-Traumatic Stress Disorders;Proestrus;psychiatric symptom;Rattus;RBM5 gene;receptor;Receptor Activation;receptor binding;Reporting;Research;response;sensor;severe mental illness;sex;Sex Differences;Signal Transduction;Sleep disturbances;Sleeplessness;Stress;stress related disorder;System;Testing;Time;Woman;women versus men;Work

PROJECT_TITLE: Investigating the mechanism by which orexins contribute to sex differences in cognitive flexibility after stress

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pain Research

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Myofascial pain syndrome (MPS), characterized by the presence of painful myofascial “trigger points”, is one of the most common forms of acute and chronic musculoskeletal pain, affecting 10-15% of patients seen in general medical clinics and as many as 85% of individuals at some point in their lifetime. Despite its clinical significance, the subjective nature of current diagnostic methods, together with the lack of objective markers of MPS, has hinders the precision of MPS diagnosis and treatment. This work aims to develop PET and MRI methods to identify novel imaging biomarkers of myofascial damage and the resultant inflammatory mediators that can diagnose and characterize MTrPs and the sources of pain in MPS.

PI_NAMEs: GOLD, GARRY E (contact);KOGAN, FELIKS

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: Acute;addiction;Affect;Age;Anatomy;Anesthetics;Area Under Curve;Assessment tool;Attention;Back;Beds;Bilateral;Biological Markers;Blood Vessels;Cervical spine;chronic musculoskeletal pain;Clinic;Clinical;Clinical assessments;clinical care;Clinical Research;clinical translation;Clinical Treatment;clinically significant;Complex;Contralateral;density;Development;Diagnosis;Diagnostic Imaging;Diagnostic Procedure;diagnostic tool;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Fascia;Fibrosis;fluorodeoxyglucose positron emission tomography;Functional disorder;Generations;Image;imaging approach;imaging biomarker;Imaging Techniques;improved;Individual;Inflammation Mediators;Inflammatory;Injections;Injury;innovation;Local Anesthetics;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Medical;Metabolic;Metabolism;Methods;Minor;Modeling;Motion;Muscle;Muscle Contraction;Muscle Fibers;Myofascial Pain Syndromes;Myofascial Trigger Point;Nature;Neurogenic Inflammation;Nodule;novel;novel imaging technique;novel marker;opioid abuse;opioid use;Pain;Pain management;Painless;Palpable;Patient Care;Patients;PF4 Gene;Phase;Positron-Emission Tomography;Prevalence;Process;Protocols documentation;randomized, clinical trials;Receiver Operating Characteristics;Research;rhomboid;Scanning;scapula;Sensitivity and Specificity;sex;Side;Single-Blind Study;Site;Skeletal Muscle;soft tissue;Source;Structure;Syndrome;Techniques;theories;Time;Tissues;tool;Tracer;trapezius muscle;treatment group;treatment response;ultrasound;uptake;Variant;Work

PROJECT_TITLE: Imaging of pain sources in myofascial pain syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 SH (14)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Lead Poisoning;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative. Exposure to metals/metalloids like arsenic, lead, and cadmium may be major risk factors for the development of Alzheimer’s Disease and Related Dementias. The goal of this project is to use advanced mouse models, which better capture genetic risk for Alzheimer’s, to understand how metals/metalloids may cause the disease and provide new strategies for early detection of at risk individuals.

PI_NAMEs: BAKULSKI, KELLY ;COLACINO, JUSTIN ADAM (contact);KACZOROWSKI, CATHERINE COOK;ZHOU, XIANG

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: Address;Adult;Age;Aging;aging brain;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;Arsenic;Behavior;Behavioral;Bioinformatics;Biological;Biological Markers;Biology;Blood;Blood specimen;Brain;Brain Mapping;Brain region;Cadmium;Data;data resource;Data Science;design;Development;Disease;Early Diagnosis;Environmental Health;Environmental Risk Factor;Epidemiology;epidemiology study;Epigenetic Process;epigenomics;Exposure to;Genes;Genetic;Genetic Predisposition to Disease;Genetic Risk;Goals;Human;human model;Impaired cognition;imprint;in vivo;Inbred Strains Mice;Individual;Intervention;late life;Lead;lead exposure;Lead levels;Life;Link;Maps;Measures;metabolomics;Metal exposure;Metals;Modeling;modifiable risk;Molecular;Molecular Profiling;mouse model;Mouse Strains;multiple omics;Mus;National Institute of Environmental Health Sciences;neuropathology;old mice;Outcome;Pathologic;Pathology;Pathway interactions;Patients;Perinatal;Perinatal Exposure;Phenotype;Population;Predisposition;prevent;Prevention;Research;Resolution;Resources;Risk;Risk Factors;Sampling;sex;Symptoms;Testing;Tissues;tool;toxic metal;toxicant;Toxicology;transcriptomics;Translating;Variant;Work

PROJECT_TITLE: The impact of metals and polygenic risk on multiomics, brain aging, and ADRD outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-P (M3)]


NIH_SPENDING_CATS: Hematology;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Transplantation

ORG_CITY: CAMDEN

ORG_NAME: CORIELL INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NJ

PHR: Narrative Clinically, the limited number of HSC in cord blood significantly affects its application for transplantation. The proposal aims to develop and optimize a new method that can expand cord blood HSC in culture and improve the outcome of clinical transplantations.

PI_NAMEs: HUANG, JIAN  (contact);KLEIN, PETER S

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Address;Adult;Affect;Agonist;Biological;Biological Assay;Biological Specimen Banks;Blood;Bone Marrow;Bone marrow failure;Cells;Chemicals;Clinical;clinical application;Clofibrate;Cord Blood Hematopoietic stem cells;Cryopreservation;cytokine;Disease;Dose;Dysmyelopoietic Syndromes;Energy Metabolism;Engraftment;etomoxir;experimental study;Exposure to;Failure;fatty acid oxidation;Fatty Acids;Fenofibrate;Fibrates;FRAP1 gene;Gemfibrozil;Genetic;Goals;graft failure;graft vs host disease;Hematological Disease;Hematopoietic Neoplasms;hematopoietic stem cell expansion;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;high throughput screening;high-throughput drug screening;Human;Hypertriglyceridemia;Immune;Impairment;improved;improved outcome;in vivo;inhibitor;knock-down;Knock-out;Libraries;Life;lipid metabolism;Maintenance;member;Methods;Molecular;Molecular Target;Mus;Myeloproliferative disease;National Heart, Lung, and Blood Institute;novel strategies;novel therapeutics;Pathway interactions;Peroxisome Proliferator-Activated Receptors;Pharmaceutical Preparations;pharmacologic;Play;Population;PPAR alpha;Procedures;Protocols documentation;reconstitution;Recovery;Registries;Resources;response;Risk;Role;self-renewal;Serum;Sirolimus;small molecule;stem cell function;success;Testing;Therapeutic;Therapeutic Uses;Transplantation;Umbilical Cord Blood;uptake

PROJECT_TITLE: Expand human umbilical cord blood hematopoietic stem cells with  PPAR-a agonists

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-K (M1)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stroke

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Discrimination in healthcare settings disproportionately affects aging Black adults and may exacerbate disparities in cardiovascular and cognitive health. This project aims to first quantify the impact of healthcare discrimination on cardiovascular conditions like stroke and myocardial infarction among Black adults aged 50 and older, then subsequently evaluate its impact on cognitive health. The research seeks to inform interventions and policies that can enhance equitable healthcare delivery, aligning with NIA's mission to improve the health of older adults.

PI_NAMEs: GREEN, MICHAEL D. (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Address;Adult;Adverse effects;Affect;age related;aged;Aging;aging population;Area;Award;Black Populations;Black race;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cognitive;Complex;Data;Data Analyses;design;Development;Discrimination;Disparity;Education;Epidemiologic Methods;Equitable healthcare;Equity;Evidence based intervention;experience;Exposure to;Fostering;Future;Goals;Health;Health and Retirement Study;health care delivery;health care settings;health data;health disparity;health equity;Health Personnel;Health system;Healthcare;Healthcare Systems;high risk;human old age (65+);implicit bias;improved;Incidence;Individual;insight;Intervention;Life Cycle Stages;Location;longitudinal analysis;Measures;Medical;Methods;middle age;Minority;Mission;Modernization;Morbidity - disease rate;mortality;multilevel analysis;Myocardial Infarction;National Institute on Aging;older adult;Outcome;outcome disparities;Patient-Focused Outcomes;Patients;perceived discrimination;Personal Satisfaction;Phase;Physicians;Policies;Population;Postdoctoral Fellow;pre-doctoral;Prevalence;Preventive care;programs;Provider;Public Health;Public Health Schools;racial difference;racial discrimination;racial health disparity;Reporting;Research;Research Personnel;Research Support;Risk;Risk Management;Role;Scientist;Shapes;skills;social stressor;Stroke;stroke incidence;stroke risk;stroke-like outcome;Structure;Surveys;System;systematic review;Time;Training;United States;Universities;Vulnerable Populations;Work

PROJECT_TITLE: Assessing the Impact of Discrimination in Healthcare on the Cardiovascular and Cognitive Health of Aging Black Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-J (M1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_CITY: TROY

ORG_DEPT: BIOLOGY

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

PHR: Project Narrative  Rensselaer Alzheimer’s Fellows to Accelerate Entrepreneurship in Life Sciences (RAFAELs) program will provide crucial training in commercialization of ADRD research, providing new courses and experiential learning in the practical aspects of advancing discoveries from early-stage startups and academic research to real-world applications.  By offering educational modules, guiding students in startup development and industrial internship, the program equips participants with the entrepreneurial skills and knowledge needed to navigate complex healthcare ecosystems in ADRD in both the short and long term.  In the short term, the Rensselaer Alzheimer’s Fellows to Accelerate Entrepreneurship in Life Sciences (RAFAELs) program enhances the potential for emerging discoveries to move from the classroom or laboratory into incubation and acceleration settings, ultimately strengthening their position for future commercial success while directly contributing to the application of knowledge to enhance health and reduce illness and disability in ADRD.

PI_NAMEs: DORDICK, JONATHAN S.;ORZECHOWSKI, BRETT ;WANG, CHUNYU  (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: Academia;Acceleration;Active Learning;Acute;Alzheimer's Disease;Alzheimer's disease related dementia;Artificial Intelligence;Award;Biological Sciences;Biology;Biotechnology;Businesses;career;Career Exploration;certificate program;Clinical Trials;commercialization;Committee Members;Complex;cost;Data Science;Dedications;Development;disability;doctoral student;drug discovery;Ecosystem;Education;Education Projects;empowerment;Engineering;Entrepreneurship;Failure;falls;Fellowship;Fostering;Funding;Future;Generations;graduate student;Health;Healthcare;Home;ideation;Incubated;Industrialization;Industry;industry partner;Infrastructure;innovation;insight;Intellectual Property;Interdisciplinary Study;Internships;Investments;Knowledge;Laboratories;Learning;Learning Module;Marketing;medical schools;Mentors;National Institute of General Medical Sciences;New York City;Participant;Pathway interactions;Positioning Attribute;pre-doctoral;precision medicine;Privatization;Process;programs;prototype;real world application;recruit;Research;Research Personnel;Role;Rotation;Science;Secure;skills;Student recruitment;Students;success;Technology Transfer;tool;Training;Training Programs;Translational Research;Translations

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-I (M2)]


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE  The development of well-trained, clinical researchers in neuroscience will foster better clinical trials design and thereby hasten the introduction of improved regimens for therapy and prevention of neurological disorders. The Clinical Trial Methodology Course in Neurological Disorders (CTMC) teaches best practices in trial development to groups of early-career physicians, psychologists, nurses, and biostatisticians. The CTMC brings rigor, new energy, and new highlights to a valuable program in the mentoring of tomorrow’s academic research leaders with a focus on diversity, equity, and inclusion for recruitment of faculty and participants.

PI_NAMEs: GUTMANN, LAURIE ;QUIGG, MARK S (contact)

PROGRAM_OFFICER_NAME: TSOU, AMY YUNG

PROJECT_TERMS: Address;Applications Grants;Area;Biometry;Budgets;career;career development;Caregivers;Clinical;clinical biomarkers;Clinical Investigator;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;community engagement;Data Analyses;design;Development;Direct Costs;Education;Educational Activities;Educational process of instructing;equity, diversity, and inclusion;Ethics;experience;Faculty;faculty mentor;Faculty Recruitment;Fellowship;forging;Fostering;Foundations;Funding;Future;Generations;Goals;Grant;Healthcare Systems;improved;Infrastructure;innovation;Institution;Investigation;Knowledge;Leadership;Location;Medical;meetings;Mentors;Mentorship;Methodology;neglect;Nervous System Disorder;Neurologic;Neurosciences;novel therapeutics;Nurses;Nursing Faculty;Participant;Patient Care;Patient Recruitments;Patients;peer coaching;Performance;Physicians;Prevention;programs;protocol development;Psychologist;recruit;Regimen;Research;Research Design;research in practice;Research Personnel;Risk;Scientist;Secure;source localization;success;Techniques;tool;Training;Training Programs;Translating;translational neuroscience;Translational Research;trial design;Underrepresented Populations;underserved community;Underserved Population;United States National Institutes of Health;Work

PROJECT_TITLE: Clinical Trials Methodology Course in Neurological Disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-F (25)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Neurosciences;Pain Research;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Our goal is to develop and assess the clinical potential of quantitative imaging biomarkers of masticatory myofascial pain syndrome. The proposed biomarkers are myofiber diameter, sarcolemma permeability and sarcomere length scale from the Random Permeable Barrier Model (RPBM) that we have developed for analysis of diffusion tensor imaging data of the muscle with varying diffusion times. We plan to further develop the data acquisition and analysis methods for the masticatory muscles, test the diagnostic performance for myofascial pain, and apply it to assessment of treatment response in masticatory myofascial pain syndrome.

PI_NAMEs: FIEREMANS, ELS ;KIM, SUNGHEON GENE  (contact);NOVIKOV, DMITRY S;REEVE, GWENDOLYN

PROGRAM_OFFICER_NAME: TUTTLE, ALEXANDER H

PROJECT_TERMS: American;analog;Anatomy;Animal Model;Anti-Inflammatory Agents;Architecture;Area;Back;Behavior Therapy;Biological Markers;biophysical properties;Biopsy;botulinum neurotoxin injection;Botulinum Toxin Type A;Botulinum Toxins;candidate marker;Clinical;clinical translation;Clinical Trials;Contracts;Data;data acquisition;Data Analyses;Development;Diagnosis;Diagnostic;Diagnostic tests;Diameter;Diffusion;Diffusion Magnetic Resonance Imaging;Excision;Fatty acid glycerol esters;Fiber;Goals;Heterogeneity;Human;Image;imaging biomarker;imaging modality;imaging probe;improved;innovation;interest;Jaw;Length;Local anesthesia;Magnetic Resonance Imaging;Maps;Masticatory muscles;masticatory myalgia;Measures;Methods;Modeling;Monte Carlo Method;Morphologic artifacts;Motion;MRI Scans;Muscle;Muscle Fibers;Musculoskeletal;Myofascial Pain Syndromes;Myofascial Trigger Point;Noise;novel therapeutics;Pain;Pain Measurement;pain relief;Parameter Estimation;Patients;Pelvis;Performance;Perfusion;Permeability;Pharmaceutical Preparations;Phase;Physical therapy;Placebos;Population;Prediction of Response to Therapy;Prevalence;Protocols documentation;Psychological Stress;quantitative imaging;reconstruction;Reproducibility;research clinical testing;Resolution;Sarcolemma;Sarcomeres;Scanning;Shoulder;Signal Transduction;Site;Skeletal Muscle;Slice;Sodium Chloride;Structure;Surface;Testing;theories;Time;Tissues;tool;Trauma;treatment response;trigger point;Visual;Visualization;volunteer;Water;water diffusion

PROJECT_TITLE: Development and Clinical Translation of RPBM for Quantitative Assessment of Myofascial Pain


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Lung;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Patient Safety;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: Newton

ORG_NAME: BIOSENSICS, LLC

ORG_STATE: MA

PHR: A significant portion of opioid fatalities occur at home, with many unwitnessed overdoses proving fatal. There is a pressing need for a device that can identify respiratory disturbances from opioid overdoses and promptly alert nearby individuals and first responders. To bridge this gap, we propose to develop ODAlert, a groundbreaking wearable device designed to sense the cessation of breathing due to opioid overdose, triggering an audio alarm that alerts nearby individuals and also contacting first responders, thus enabling timely intervention and increasing the odds of saving lives from opioid overdose.

PI_NAMEs: NAJAFI, BIJAN ;VAZIRI, ASHKAN  (contact)

PROGRAM_OFFICER_NAME: ANGELONE, LEONARDO MARIA

PROJECT_TERMS: Abdomen;Accelerometer;Address;Adherence;Adult;Adverse event;Agreement;Algorithm Design;Algorithms;Anxiety;Auditory;Awareness;battery life;biomaterial compatibility;Breathing;Caring;Clinical;clinical practice;Clinical Research;cloud platform;Collaborations;college;commercialization;Companions;Consent;Dangerousness;Data;Death Rate;design;Detection;Development;Device Designs;Devices;Documentation;Drug user;effective intervention;efficacy study;Emergency response;Emergency Situation;empowerment;Ensure;experience;Feedback;first responder;Fostering;Funding;Guidelines;Harm Reduction;Health;Healthcare;Home;Hypoxia;improved;Individual;Injections;innovation;Institutional Review Boards;Intention;Interruption;Intervention;Interview;Life;Location;Marketing;Measures;Medicine;meetings;Microprocessor;mobile application;Modeling;Monitor;mortality;Naloxone;naloxone dispensing;National Institute of Drug Abuse;Notification;Opioid;opioid epidemic;opioid overdose;opioid use disorder;Outcome;Overdose;Participant;Patients;Pattern;Performance;Phase;phase 2 study;Pilot Projects;Policies;primary outcome;Privacy;programs;Protocols documentation;Public Health;Randomized;Reaction;Readiness;Recommendation;Research;Research Design;respiratory;response;Safety;screening;secondary outcome;Secure;Security;Self Management;Sensitivity and Specificity;sensor;Signal Transduction;Skin;smartphone application;success;support network;Surveys;System;technological innovation;Technology;Testing;Time;tool;United States;Validation;validation studies;Ventilatory Depression;virtual;wearable device;wearable health device;Weight

PROJECT_TITLE: ODAlert: Wearable Device for Automatic Detection of Opioid-Induced Respiratory Arrest


ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Impaired renal microcirculation caused by urinary tract obstruction is a significant cause of childhood kidney injury. The concept that neonatal obstructive vasculopathy is associated with ET-induced activation of vascular smooth muscle TRPC3 channels is a new paradigm for understanding the pathophysiology of this important disease. The outcome of the studies proposed in this application may lead to diagnostic and therapeutic targets to prevent renal loss in newborns with urinary tract obstruction.

PI_NAMEs: ADEBIYI, ADEBOWALE  (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Anabolism;Animals;Atrophic;Big Endothelin;Biological Assay;Biological Markers;Blood capillaries;Blood Vessels;Calcium;Childhood;Chronic Kidney Failure;cohort;Data;Development;Diagnostic;diagnostic biomarker;Diglycerides;Disease;EDN1 gene;Electrophysiology (science);Endothelin;Endothelin Receptor;Endothelin-1;Endothelin-2;Endothelin-3;Endothelin-converting enzyme 1;epithelial to mesenchymal transition;Event;extracellular;Family suidae;Fibrosis;Functional disorder;Glomerular Filtration Rate;hemodynamics;Histologic;Homeostasis;hypoperfusion;Image;Impairment;improved;Infant;Inflammation;inhibitor;Injury to Kidney;innovation;Intensive Care;interest;Intervention;Ion Channel;Kidney;Kidney Diseases;Kidney Failure;kidney vascular structure;Knock-out;Left;Link;Mediating;Microcirculation;multiphoton microscopy;Myography;NADPH Oxidase;Neonatal;neonate;Newborn Infant;novel;Obstruction;Outcome Study;patch clamp;Pathway interactions;Peptide Hydrolases;Perfusion;Perinatal;pharmacologic;Physiological;Pilot Projects;porcine model;pre-clinical;Pre-Clinical Model;pressure;prevent;Process;Production;protein expression;Protein Isoforms;Proteolytic Processing;Rat Strains;Rattus;Reactive Inhibition;Reactive Oxygen Species;real-time images;receptor;Receptor Activation;receptor operated channel;Regional Blood Flow;Renal function;Renal Replacement Therapy;Research;Signal Transduction;Smooth Muscle Myocytes;Techniques;Testing;therapeutic target;Time Study;TRPC3 ion channel;Tubular formation;Ureteral obstruction;urinary;urinary tract obstruction;Urine;Vascular Diseases;Vascular resistance;Vascular Smooth Muscle;vasoconstriction;Vasodilation;Weaning

PROJECT_TITLE: Vascular ion channels and microcirculation in neonatal urinary tract obstruction

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]