ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PHR: A limiting barrier in developing effective treatments for Alzheimer’s disease (AD) is the lack of understanding of  how Abeta and tau cooperate to trigger and exacerbate this disease. We recently uncovered more than one  hundred genes capable of modifying the synergistic damage caused by Abeta and tau in a fruit fly model of AD  and we plan to interrogate them molecularly and genetically to selectively identify the most robust and promising  targets. Therefore, this research is relevant to public health because it has the potential to identify new genes  and molecular pathways that could block, delay, or prevent this devastating disorder.

PI_NAMEs: RINCON-LIMAS, DIEGO E (contact)

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: Address;Aging;Alzheimer's Disease;Alzheimer's disease model;Amyloid;Amyloid beta-42;Autophagocytosis;Behavioral;Behavioral Assay;Binding;Biological Assay;Brain Diseases;C9ORF72;candidate validation;Cell Cycle;Cellular Metabolic Process;Chromatin;Collection;Complex;Cytoskeletal Proteins;Data;Data Set;deletion analysis;Dementia;Deposition;design;Development;Dipeptides;Disease;Disease Progression;Drosophila genus;effective therapy;Elderly;Enhancers;Ensure;extracellular;Eye;flexibility;fly;Foundations;gene discovery;Genes;Genetic;Genetic Screening;Genetic Transcription;Goals;Homeostasis;Homologous Gene;Human;hyperphosphorylated tau;Impaired cognition;Label;Link;loss of function;Mediating;Memory Loss;MJD1 protein;Molecular;Names;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuron loss;Neurons;neuropathology;neuroprotection;neurotoxic;novel;Ontology;Other Genetics;Pathogenesis;Pathologic;Pathology;Pathway interactions;Pattern;Peptides;Phenotype;Phosphorylation;Phosphotransferases;Play;Post-Translational Protein Processing;prevent;Property;protein TDP-43;Proteins;Proteolysis;Public Health;Reporting;Research;Ribosomes;RNA Interference;RNA interference screen;RNA Splicing;Role;Senile Plaques;System;tau interaction;tau mutation;tau Proteins;Testing;Therapeutic;Thioflavin S;Time;tool;Toxic effect;Ubiquitination;Work

PROJECT_TITLE: Harnessing new targets and mechanisms mediating AD pathogenesis

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Eye Disease and Disorders of Vision;Genetics;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: DERMATOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Narrative Uveal melanoma (UM) is the most common eye cancer with a 50% mortality due to metastasis to the liver. No effective treatments for metastatic disease exist. Our proposed studies aim to expand on our discovery of the key drivers of this disease with the goal to identify molecular targets for new treatment approach for UM patients.

PI_NAMEs: CHEN, XU  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Automobile Driving;Binding;BRAF gene;Cell membrane;Cell Proliferation;ChIP-seq;clinical efficacy;Clinical Trials;Combined Modality Therapy;Complication;Coupled;CRISPR/Cas technology;Cutaneous Melanoma;Data;design;Diglycerides;Disease;effective therapy;Enhancers;Epigenetic Process;experience;experimental study;Feedback;Future;Generations;Genetic;Genetic Engineering;Genetic Transcription;Genetically Engineered Mouse;GNAQ gene;Goals;Guanine Nucleotide Exchange Factors;immune checkpoint blockade;improved;inhibitor;innovation;knock-down;Knock-in Mouse;Knock-out;Knockout Mice;Link;Liver;malignant neoplasm of eye;Malignant Neoplasms;MAP kinase activator;MAP Kinase Gene;Mediating;MEK inhibition;MEKs;Melanoma;Melanoma patient;Metastatic Neoplasm to the Liver;Metastatic to;Mitogen-Activated Protein Kinases;Molecular;Molecular Biology;Molecular Genetics;molecular pathology;Molecular Target;mortality;mouse model;mutant;Mutation;Neoplasm Metastasis;new therapeutic target;NF1 gene;novel;novel therapeutic intervention;Oncogenic;Output;overexpression;Pathway interactions;Patients;pharmacologic;Phospholipase;Phospholipase C;phosphoproteomics;Phosphorylation;Phosphotransferases;pre-clinical;prevent;Proliferating;Protein Inhibition;Protein Kinase C;protein kinase D;Reagent;receptor;Regulation;Research Personnel;Resistance;response;Signal Pathway;Signal Transduction;Somatic Mutation;success;System;targeted treatment;Testing;therapeutic target;tool;Toxic effect;transcription factor;transcriptome sequencing;Treatment Efficacy;Up-Regulation;Uveal Melanoma;Xenograft Model

PROJECT_TITLE: RasGRP3 and Protein Kinase D as therapeutic targets for Uveal Melanoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: RALEIGH

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: Project Narrative The vertebrate left-right (LR) body axis specifies the proper anatomical position and morphology of multiple organs; thus, abnormal LR asymmetry, known as heterotaxy (HTX), can cause catastrophic syndromes of laterality-related birth defects. In the proposed project, we test the idea that the asymmetry of a specific organ, the stomach, is shaped by LR asymmetries in cellular metabolism. As such, this research may help resolve previously unexplained causes of human laterality defects involving mutations in metabolism genes or environmental disruptions of maternal and/or embryonic metabolic homeostasis.

PI_NAMEs: NASCONE-YODER, NANETTE M (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Alcohol consumption;Amphibia;Anatomy;Binding Sites;Biological Assay;Body System;Candidate Disease Gene;Cell Physiology;Cells;cocaine use;Complex;Congenital Abnormality;Data;Defect;Development;Embryo;Enzymes;epidemiology study;epithelial to mesenchymal transition;Epithelium;Event;gain of function;Gene Expression;gene function;Gene Order;Genes;Genus Hippocampus;Glucose;Glycolysis;Goals;Handedness;Homeostasis;Human;Individual;inhibitor;knock-down;Left;Life;loss of function;malformation;mass spectrometric imaging;maternal diabetes;Mediating;Mesenchymal;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;Molecular;Morphogenesis;Morphology;Mutation;novel;Organ;Organogenesis;pharmacologic;Phenotype;Positioning Attribute;Publishing;Rana;Reagent;Regulation;Research;Respiration;Role;Shapes;Side;Situs Inversus;Smoking;Specific qualifier value;Stomach;Syndrome;Testing;Thinness;Transcript;transcription factor;transcriptome sequencing;transcriptomic profiling;Vertebrates;Work;Xenopus;Xenopus laevis

PROJECT_TITLE: Fueling left-right asymmetry: the role of glycolysis in stomach curvature

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: Lung cancer is the leading cause of cancer death among Veterans, and Black men have the highest rate of lung cancer diagnoses and deaths of any group in the US. Lung cancer screening with yearly chest scans can prevent lung cancer deaths, but only 10% of eligible Veterans have been screened, with lower rates among Black people than white people. Outside the VA, trained community peers are effective to increase cancer screening rates among minority populations. In this pilot project we will develop a Veteran Peer Specialist-led program to support and empower Black Veterans to engage in lung cancer screening. The Peer-led program will be designed with input from Black Veterans and will include community outreach, group education, and one-on-one support personalized to the needs of individual Black Veterans. We will pilot test this program in the VA Boston Healthcare System in partnership with local community organizations that serve Black Veterans. This pilot work will allow us to refine the Peer-led program and to plan a subsequent multi-site study.

PI_NAMEs: WIENER, RENDA SOYLEMEZ (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;Age;Awareness;behavior change;black lung;black men;Black Populations;Black race;black women;Boston;cancer diagnosis;Cancer Etiology;Cessation of life;Chest;Clinical;Communities;community based research;community engagement;community intervention;community organizations;Community Outreach;community partners;cost;Data;data warehouse;design;Disparity;disparity reduction;Distress;Education;effectiveness evaluation;effectiveness/implementation hybrid;Eligibility Determination;empowerment;Enrollment;Ensure;Equity;Ethnic Origin;expectation;Feasibility Studies;Geography;Goals;Health;health disparity;health equity;Healthcare Systems;Homogeneously Staining Region;implementation/effectiveness;improved;Incidence;innovation;Intervention;Interview;Knowledge;Lead;Lived experience;lung cancer screening;Malignant neoplasm of lung;Manuals;marginalized population;Medical Care Team;Methodology;Minority Groups;mortality;novel;Outcome;outreach program;Pamphlets;Participant;peer;peer coaching;peer support;Periodicals;Persons;Pilot Projects;pilot test;Positioning Attribute;precision oncology;President's Cancer Panel;prevent;primary outcome;Procedures;Process;programs;Provider;Recommendation;Research;research and development;residence;Role;Scanning;Screening for cancer;screening program;Self Efficacy;Services;Site;Smoking;smoking cessation;social cognitive theory;social health determinants;social stigma;Social support;Specialist;Stigmatization;Strategic Planning;Structural Racism;Suggestion;Surveys;Testing;Tobacco;Training;Trust;Underserved Population;uptake;Veterans;virtual;Vulnerable Populations;Work;X-Ray Computed Tomography

PROJECT_TITLE: Co-Design and Pilot Testing of Peer-led Community Outreach to Improve Equity, Veteran-Centeredness and Uptake of Lung Cancer Screening

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: Every day, Veterans across the Veterans Health Administration (VHA) are discharged home with vascular access devices for delivery of outpatient parenteral antimicrobial therapy (OPAT). Although OPAT is a vital part of Veteran care, we know very little about how it is managed or the challenges Veterans and their caregivers experience. Because adverse events are possible, this information is critical to identify gaps in care and develop strategies for Veterans to receive safe, effective therapy. This study engages Veterans, caregivers and clinical care providers using multiple methods including semi-structured interviews, surveys, video reflexive ethnography, and photo elicitation to gain a deeper understanding of the challenges encountered related to the delivery and administration of at-home OPAT. We will also engage these stakeholders in a collaborative co-design process to develop interventions for improving OPAT care and management at home. Importantly, this work will inform OPAT related policy and practice within VHA.

PI_NAMEs: HARROD, MOLLY  (contact);KREIN, SARAH

PROJECT_TERMS: acceptability and feasibility;active method;Address;Adverse event;Allergic Reaction;Ambulatory Monitoring;Antibiotics;antimicrobial;Area;Blood Vessels;care coordination;care delivery;care providers;Caregivers;Caring;Catheters;Clinical;clinical care;Collaborations;Communicable Diseases;Communication Barriers;Confusion;Contract Services;Contracts;Data Analyses;design;Devices;Education;effective therapy;Elements;Emergency department visit;Engineering;Ensure;Ethnography;Event;experience;Face;Foundations;Goals;Guidelines;Health Care Costs;Health Professional;Home;Home environment;Home Infusion Therapy;hospital readmission;Hospitals;improved;Industry;Infection;informal caregiver;informant;Infusion procedures;innovation;Inpatients;Intervention;Interview;Intravenous;Knowledge;Laboratories;Learning;Medical center;medication compliance;member;Methodology;Methods;Monitor;Needles;nephrotoxicity;novel;Nursing Services;Outcome;Outcome Measure;Outpatients;Patient Discharge;patient home care;Patient Monitoring;patient safety;Patients;Pharmaceutical Preparations;Pharmacy facility;Physicians;Policies;Process;programs;Protocols documentation;Provider;Research;Resources;Role;Safety;Sampling;Site;Structure;Surveys;System;Task Performances;therapy design;Training;Treatment Effectiveness;United States;user centered design;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Ensuring Safe and Effective Delivery of Outpatient Parenteral Antimicrobial Therapy for Veterans

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ORG_CITY: BALTIMORE

ORG_NAME: BALTIMORE VA MEDICAL CENTER

ORG_STATE: MD

PHR: Falls are a major health concern in older Veterans. Evidence suggests that abnormalities, related to disuse, in muscles of the hips may have a major role in fall risk. This application will use novel methods of exercise to address improving the muscles of the hips as a means of reducing falls. If successful, this application will provide new practical methods to improve balance and reduce falls by improving the hip muscles in older Veterans.

PI_NAMEs: ADDISON, ODESSA  (contact)

PROJECT_TERMS: Address;Adipose tissue;Age;Area;Balance training;Caring;Cessation of life;Clinical Treatment;cost;cost effective;Data;Educational Intervention;Electrodes;Equation;Equilibrium;Exercise;exercise training;Exhibits;Fall prevention;fall risk;falls;Fascia lata structure;Fatty acid glycerol esters;follow-up;functional outcomes;Future;Gait;Health;Hip region structure;Hospitalization;Impairment;improved;Incidence;Infiltration;Injury;Intervention;intervention program;Intramuscular;Isometric Exercise;Lower Extremity;Mechanics;Methods;Mission;multimodality;Muscle;Muscle Contraction;muscle form;Muscle function;muscle strength;Muscular Atrophy;neuromuscular stimulation;novel;older adult;patient oriented;patient safety;performance tests;Physical Performance;Prevention program;primary outcome;programs;Publishing;Randomized, Controlled Trials;Recommendation;recruit;Rehabilitation therapy;Research;response;Role;Step Tests;Surface;Testing;Time;tool;Training;Translational Research;Trauma;Veterans;Work;X-Ray Computed Tomography

PROJECT_TITLE: Reducing Fall Risk with the use of Neuromuscular Electrical Stimulation to Maximize the Hip Abductor Muscles in Older Veterans

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


NIH_SPENDING_CATS: Biotechnology;Cancer;Skin Cancer

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: This research project will provide insight into how a newly identified metastasis pathway, previously implicated only in blood cell trafficking, could be exploited to inhibit melanoma progression. Our studies will validate, in pre-clinical melanoma models, the potential therapeutic utility of commercially available pathway inhibitors used in other disease settings, for blocking cancer metastasis. Results from this project will yield the first in- depth target characterization in clinical tumor biospecimens and pave the way for the development of more potent and cancer-selective therapeutics targeting this cellular trafficking pathway.

PI_NAMEs: BARTHEL, STEVEN RUSSELL;SCHATTON, TOBIAS  (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Adhesions;Adhesives;antagonist;Antibodies;Autoimmune;Autoimmunity;Biological Assay;Blocking Antibodies;Blood Cells;cancer cell;cancer immunotherapeutics;CD44 gene;Cell Adhesion;Cell Lineage;Cells;cellular targeting;Cessation of life;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;CRISPR/Cas technology;crosslink;Data;Dermatopathology;Development;Disease;Disseminated Malignant Neoplasm;efficacy evaluation;Endothelial Cells;Endothelium;Epitopes;FDA approved;Frequencies;Genes;Glycobiology;Glycoproteins;glycosylation;Growth;Hematopoietic;hemodynamics;Home;Homing;Human;human model;humanized antibody;Immune;immune-related adverse events;improved;in vivo;in vivo imaging;Inflammation;Inflammatory;inhibitor;innovation;insight;Integrin Inhibition;Integrins;Intercellular adhesion molecule 1;Intercellular Adhesion Molecules;ITGAM gene;ITGAX gene;ITGB2 gene;Knock-out;Knockout Mice;Lectin;leukocyte homing;Leukocyte Trafficking;Leukocyte Trafficking Induction;Leukocytes;Ligands;luminescence;Macrophage;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mediator;Melanoma;Melanoma Cell;Melanoma patient;Metastatic Melanoma;Metastatic Neoplasm to Lymph Nodes;migration;Migration Assay;Modality;Modeling;Molecular Conformation;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;New Agents;new therapeutic target;Non-Malignant;novel;novel therapeutics;Outcome;Pathway interactions;Patient imaging;Patient-Focused Outcomes;Patients;Peripheral;pharmacologic;Polysaccharides;Positive Lymph Node;pre-clinical;Predisposition;Primary Neoplasm;Process;Prognosis;Reagent;Regulation;Research Project Grants;RNA Interference;Role;Sentinel Lymph Node;Solid Neoplasm;System;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Time;Tissues;tool;Toxic effect;trafficking;translational study;Treatment Efficacy;Treatment outcome;tumor;Tumor Cell Line;tumor progression;tumor xenograft;tumorigenesis;Variant;Vascular Endothelium;Vertebral column

PROJECT_TITLE: Functional analysis of a novelintegrin-dependent metastasis pathway in melanoma

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Kidney Disease

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Altered circadian rhythms and impaired mineral balance, including excess circulating phosphate (Pi) and fibroblast growth factor (FGF)-23, are two hallmarks of progressive Chronic Kidney Disease (CKD). FGF23 and Pi are associated with faster CKD progression and mortality. This project proposes to test the disruption of the kidney circadian clock as a mechanism mediating FGF23 and Pi adverse effects on kidney function, thus providing potential therapeutic targets for individuals with CKD.

PI_NAMEs: MARTIN, ALINE C (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Acceleration;Acute;Adverse effects;adverse outcome;Affect;American;Animals;arm;ARNTL gene;Blood Pressure;bone;Cardiovascular system;Cells;Cessation of life;ChIP-seq;Chronic;Chronic Kidney Failure;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clinical;Data;Development;Diet;dietary;Disease;Disease Progression;Enterobacteria phage P1 Cre recombinase;Epidemic;Equilibrium;Event;Familial hypophosphatemic bone disease;Feedback;fibroblast growth factor 23;Fibroblast Growth Factor Receptor 1;Fibroblast Growth Factor Receptors;Gene Expression;Gene Targeting;Genes;Genetic;genetic approach;Genetic Transcription;Goals;Growth;Homeostasis;Human;Impairment;improved;in vivo;Individual;Inflammation;Inflammatory;inhibitor;innovation;inorganic phosphate;Kidney;kidney cell;Kidney Diseases;Knock-in;Knowledge;life span;Link;Luciferases;Mediating;Metabolism;Minerals;Modeling;Molecular;molecular clock;Molecular Target;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Outcome;overexpression;Pathology;Pathway interactions;Patients;Periodicity;pharmacologic;prevent;Process;Productivity;Proteins;Public Health;Regimen;Regulation;Renal function;Reporter;Resources;response;Role;Serum;Signal Transduction;skills;Slice;Supplementation;Testing;Therapeutic;therapeutic target;Transcriptional Regulation;transcriptome sequencing;Universities;Wild Type Mouse

PROJECT_TITLE: Role of FGF23 and Phosphate in Chronic Kidney Disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: U54 CENTER NARRATIVE Despite rapid advances in new anti-cancer therapeutics, for many solid cancers complete remission is still rare. In many cases, tumors eventually develop resistance to treatments. One of the major barriers to effective therapeutics is likely to be potentiated by highly transcriptionally plastic cancer stem cells. In this U54 Northwestern University Center for Chromatin Nanoimaging in Cancer, we will develop, optimize, test, and deploy new nanoimaging technologies, integrated with state-of-the-art molecular and computational methods, to address some of the long-standing questions related to the origin of cancer stem cells and their ability to adapt to chemotherapies. Addressing these fundamental knowledge and technology gaps may help identify new therapeutic strategies that prevent tumor resistance to therapeutics and relapse after treatment.

PI_NAMEs: BACKMAN, VADIM  (contact);MATEI, DANIELA E;ZHANG, HAO F

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;Address;Aftercare;anti-cancer research;anti-cancer therapeutic;Biological Assay;Cancer Biology;cancer cell;cancer stem cell;Cell Nucleus;Cell Physiology;Cells;cellular imaging;chemotherapy;Chromatin;Chromatin Structure;Complex;Computing Methodologies;Cytotoxic Chemotherapy;Data;data modeling;Data Set;Development;Diameter;Disease remission;Disparate;DNA;Electron Microscopy;electron tomography;Epigenetic Process;epigenomics;Event;Feedback;follow-up;Fostering;frontier;Future;Genes;Genetic;Genetic Transcription;Genome Mappings;Genomics;Growth;Heterogeneity;Image;imaging capabilities;imaging platform;Imaging Techniques;Imaging technology;insight;Knowledge;Label;Length;Link;live cell microscopy;Malignant Neoplasms;Methods;Microscopy;Mission;Molecular;Molecular Conformation;molecular imaging;molecular modeling;molecular scale;Molecular Target;nanoimaging;nanoscale;Nanoscopy;nanosensors;new technology;novel therapeutic intervention;novel therapeutics;Oncology;Optics;Pathway interactions;Pattern;Physics;Play;Population;pressure;prevent;Process;programs;quantitative imaging;Relapse;Research;Resistance;Resistance development;Resolution;Role;Scanning;Series;single cell genomics;single molecule;Solid;spatiotemporal;stem;stem cell biology;Stem Cell Research;stressor;Techniques;Technology;technology development;temporal measurement;Testing;Therapeutic;therapeutically effective;therapy resistant;three dimensional structure;Time;transcriptional reprogramming;Translating;Transmission Electron Microscopy;tumor;tumor progression;ultra high resolution;Universities;Vision;Visualization

PROJECT_TITLE: Northwestern University Center for Chromatin NanoImaging in Cancer (NU-CCNIC)


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: BACKMAN, VADIM  (contact)

PROJECT_TERMS: Administrator;Advocate;anti-cancer research;Award;Back;Beds;Biomedical Engineering;Biomedical Research;Cancer Biology;Cancer Center;cancer imaging;Cancer Patient;cancer stem cell;cancer therapy;Chromatin;Collaborations;Communication;Communities;Comprehensive Cancer Center;data quality;data sharing;Decision Making;design;Development;diversity and equity;diversity and inclusion;Educational workshop;Engineering;Ensure;Equity;equity, diversity, and inclusion;Evaluation;Event;experience;Fostering;Funding;Goals;graduate school;Human Resources;Image;Imaging Techniques;improved;Infrastructure;innovation;Knowledge;Leadership;Malignant Neoplasms;medical schools;meetings;member;minority health;Mission;Modeling;molecular modeling;Monitor;nanoimaging;Patients;Process;Program Evaluation;programs;Publications;Quality Control;Recommendation;Records;recruit;Reporting;Reproducibility;Research;research data dissemination;Research Personnel;Research Project Grants;Resource Allocation;Resource Sharing;Resources;Schedule;Schools;Site Visit;Specialist;synergism;Techniques;technology development;technology research and development;Testing;Training;Underrepresented Minority;Universities;Validation;Veterans;web site;Work

PROJECT_TITLE: Administration and Coordination Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Hematology;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Defects in B cell development are major causes of immunological diseases. By investigating where and how B cells migrate and position within bone marrow we may develop new therapeutic strategies against devastating immunodeficiencies, malignancies, and autoimmune diseases.

PI_NAMEs: PEREIRA, JOAO  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Address;Attention;attenuation;Autoimmune Diseases;B-Cell Development;B-Lymphocytes;Bacterial Infections;Behavior;Binding;Blood-Borne Pathogens;Bone Marrow;Cell Compartmentation;cell growth;Cell Lineage;Cell Maintenance;cell motility;Cell Shape;Cells;chemokine;cytokine;Defect;Development;DNA Double Strand Break;Dose;Down-Regulation;Emergency Situation;Ensure;experimental study;Goals;Grant;Hematopoiesis;Hematopoietic;Hematopoietic Cell Production;Hematopoietic stem cells;Home;Homeostasis;Homing;Hour;IL7 gene;Immune System Diseases;immunodeficiency;in vivo;Infection;Inflammation;Inflammatory;Left;leptin receptor;Ligands;Listeria monocytogenes;Lymphatic Endothelial Cells;Lymphocyte;Lymphoid;Lymphoid Cell;Lymphopenia;Lymphopoiesis;lymphotoxin beta receptor;Malignant Neoplasms;Mature B-Lymphocyte;Mediating;Mesenchymal Stem Cells;Molecular;Molecular Analysis;Myelogenous;Myeloid Cells;Myelopoiesis;Natural Immunity;novel;novel therapeutic intervention;Output;Pathway interactions;Peripheral;Play;Positioning Attribute;Preleukemia;prevent;Process;Production;Quality Control;receptor;Receptor Signaling;Research;response;Reticular Cell;Role;secondary lymphoid organ;Signal Transduction;stem cell delivery;stem cell survival;stem cells;Stromal Cell-Derived Factor 1;Stromal Cells;Systemic infection;systemic inflammatory response;T memory cell;tertiary lymphoid organ;Testing;TNFRSF1A gene;trafficking;Tumor Necrosis Factor-Beta;Virus Diseases;Visualization

PROJECT_TITLE: Cellular and molecular analysis of B lymphocyte development and selection

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: ZHANG, HAO F (contact)

PROJECT_TERMS: 3-Dimensional;Address;anti-cancer research;Beds;Behavior;Budgets;Cancer Biology;cancer cell;cancer stem cell;Cell Nucleus;Cell Physiology;Cells;cellular imaging;Chemoresistance;chemotherapy;Chromatin;chromatin remodeling;Chromatin Structure;Clustered Regularly Interspaced Short Palindromic Repeats;Color;Communities;Computer Models;Crowding;Data;data platform;Development;Diameter;DNA;Electron Microscopy;Ensure;Epigenetic Process;Etiology;Family;Feedback;Gene Expression;Genes;Genetic Transcription;Genome Mappings;genome sequencing;genomic locus;Genomics;Goals;Heterogeneity;histone modification;Image;imaging capabilities;imaging platform;improved;Label;light intensity;Link;Location;Longterm Follow-up;Malignant Neoplasms;Messenger RNA;meter;Methods;microscopic imaging;Microscopy;Modality;Modeling;Modification;Molecular;Molecular Analysis;Molecular Computations;Molecular Conformation;molecular dynamics;molecular imaging;molecular modeling;molecular scale;Molecular Target;nano;nanoassembly;nanoimaging;nanoscale;nanosensors;new technology;next generation;novel;Nucleosomes;Optics;Pattern;Phenotype;Photons;Physics;Polymers;Population;predictive modeling;Preparation;Process;Quantum Dots;Reaction;Regulator Genes;Research;Research Personnel;Resistance;Resolution;response;role model;Sampling;Scanning;sensor technology;single molecule;spatiotemporal;spectroscopic imaging;statistics;stem;success;Techniques;Technology;technology development;Testing;theories;Therapeutic;three dimensional structure;Time;Tissues;transcriptional reprogramming;Transmission Electron Microscopy;ultra high resolution;Universities;Visualization;Work

PROJECT_TITLE: Technology Development Unit


ADMINISTERING_IC: HG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: SALSBURY COVE

ORG_NAME: MOUNT DESERT ISLAND BIOLOGICAL LAB

ORG_STATE: ME

PHR: PROJECT NARRATIVE The goal of our two-week short course, Reproducible and FAIR Bioinformatics Analysis of Omics Data, is to provide a unique cross-training, experiential, educational opportunity for biomedical research scientists-in- training to begin to develop core competency in bioinformatics and biostatistical analyses of large data sets.

PI_NAMEs: HAMPTON, THOMAS H;STANTON, BRUCE A. (contact)

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Active Learning;Address;Advisory Committees;Big Data;Bioinformatics;Biological;Biomedical Research;biomedical scientist;Biometry;Cancer Education Grant Program;career;Competence;Data;Data Analyses;data reuse;design;Education;Educational Curriculum;Educational process of instructing;Ensure;Environment;Ethics;Euclidean Space;Evaluation;Exercise;expectation;experience;Experimental Designs;experimental study;Faculty;FAIR principles;Feedback;follow-up;Frustration;Goals;graduate student;Guidelines;High Performance Computing;improved;instructor;interest;job market;Laboratories;large datasets;Learning;Learning Skill;Linear Models;Long-Term Effects;Longterm Follow-up;Machine Learning;Maps;Measurement;Measures;Metagenomics;microbiome;Modernization;next generation;Occupations;open source;Outcome;Participant;Postdoctoral Fellow;Principal Component Analysis;Principal Investigator;Process;programs;Reporting;Reproducibility;Research;Research Personnel;response;responsible research conduct;Scientist;Secure;single-cell RNA sequencing;skills;Students;Surveys;Techniques;Testing;Training;Training and Education;transcriptome sequencing;United States National Institutes of Health;Visualization

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM(O1)-G]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Women's Health Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative Up to 97% of gender-diverse individuals assigned female at birth have gender-related voice problems, yet there are currently no evidence-based treatments for voice masculinization. Gender-affirming hormone therapy with exogenous testosterone is the default treatment, yet we still do not know how and when it works, nor in whom. The project will allow for evidence-based guidance about when and how communication will be impacted by testosterone therapy.

PI_NAMEs: STEPP, CARA E. (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Adult;Age;Anatomy;assigned female at birth;base;Birth;Caring;Characteristics;clinical care;Clinical Trials;common treatment;Communication;Data;design;Disparity;Evaluation;evidence base;Evidence based treatment;expectation;experience;flexibility;Frequencies;Future;Gender;gender affirmation;gender affirming hormone therapy;gender diverse;Gender Identity;Goals;Health;Height;high risk;Individual;individual response;individualized medicine;Intervention;Knowledge;Laryngoscopy;Larynx;Left;Length;Magnetic Resonance Imaging;Masculine;Measures;Medical;Mental Health;Modeling;Modification;Observational Study;Outcome;Outcome Measure;Participant;Patients;Perception;physical conditioning;Physiological;Population;Populations at Risk;Puberty;Reporting;Research;Risk;Safety;Salivary;satisfaction;sex assigned;Speech;Speech Acoustics;targeted treatment;Testing;Testosterone;theories;therapeutic target;Thick;treatment response;Underserved Population;Violence;vocal cord;Voice;Voice Disorders;Weight;Work

PROJECT_TITLE: Effects of exogenous testosterone therapy on communication in gender diverse speakers


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Ovarian Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

PI_NAMEs: MATEI, DANIELA E (contact)

PROJECT_TERMS: 3-Dimensional;Address;ATAC-seq;Automobile Driving;Back;Beds;Biological;cancer cell;Cancer Model;cancer stem cell;Cell Differentiation process;Cells;Chemoresistance;chemotherapy;ChIP-seq;Chromatin;Chromatin Structure;Complex;Computer Analysis;Computer Models;conventional therapy;Coupled;Coupling;Data;Disease;Environment;Epigenetic Process;epigenome;epigenomics;Event;Feedback;Frequencies;frontier;Gene Expression;Genetic Transcription;Genome Mappings;genome-wide;genomic profiles;Genomics;Goals;Hi-C;high resolution imaging;histone modification;Image;Imaging Device;imaging modality;imaging platform;Imaging Techniques;Imaging technology;in vivo;inhibitor;innovation;Knowledge;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;Modality;Modeling;Modification;Molecular;Molecular Analysis;Molecular Computations;Molecular Conformation;nanoimaging;nanoscale;Outcome;Pathway interactions;Pattern;Phenotype;physical property;Platinum;Pluripotent Stem Cells;Population;pressure;programs;Property;Recurrence;refractory cancer;Relapse;Repression;Research;Resistance;Resolution;Resources;Science;self-renewal;single cell mRNA sequencing;Source;stem cell therapy;stem cells;stemness;stressor;superresolution imaging;targeted agent;Technology;technology development;technology research and development;Testing;Theoretical model;Tissues;transcription factor;transcriptional reprogramming;transcriptome;transcriptomics;tumor;tumor initiation;tumor microenvironment;tumor progression;tumorigenic;Universities;Work

PROJECT_TITLE: Research Test-Bed Unit


ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

PHR: PROJECT NARRATIVE Type 2 diabetes (T2D) is a complex disorder that places substantial burden on the medical and public health systems. Pancreatic islet dysfunction and failure is central to type 2 diabetes. In this project, we apply innovative genomic profiling and (epi)genome editing technologies to determine the genetic programming and cellular control of human islet metabolic and endoplasmic reticulum (ER) stress responses, which are fundamentally linked to islet dysfunction and T2D pathogenesis.

PI_NAMEs: STITZEL, MICHAEL LEE (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Acceleration;Alleles;Apoptosis;ATAC-seq;Beta Cell;Binding;biological adaptation to stress;Biological Assay;Cell Line;Cell Proliferation;Cell Survival;cellular resilience;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Compensation;Complement;Complex;Computer Analysis;CRISPR/Cas technology;Custom;cytokine;Data;Diabetes Mellitus;diabetes pathogenesis;diabetes risk;diabetogenic;Disease;endoplasm;Endoplasmic Reticulum;endoplasmic reticulum stress;epigenomics;Etiology;Exposure to;Failure;Functional disorder;Funding;Gene Expression;Genes;Genetic;genetic manipulation;Genetic Programming;Genetic Risk;Genetic Transcription;genetic variant;Genetic Variation;genome editing;genome wide association study;genome-wide;genomic locus;genomic profiling;Genotype;Glucose;Guide RNA;Health system;Human;Human Genetics;in vivo;Individual;Inflammatory;innovation;insight;Insulin;Insulin Resistance;islet;Islets of Langerhans;Knowledge;Link;Location;loss of function;Measures;Medical;Metabolic;Metabolic stress;Molecular;new therapeutic target;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;overexpression;Palmitates;Pathogenesis;Pathway interactions;Peripheral;Physiological Processes;Predisposition;prevent;Proteins;Public Health;Quantitative Trait Loci;Regulation;Regulatory Element;Reporter;Repression;Research;Resistance;response;Risk;RNA library;Single Nucleotide Polymorphism;single-cell RNA sequencing;Stress;stressor;Technology;Testing;Thapsigargin;Tissues;trait;transcription factor;Transcriptional Regulation;transcriptome sequencing;Tunicamycin;Untranslated RNA;Variant

PROJECT_TITLE: Genetic programming of human islet metabolic and endoplasmic reticulum (ER) stress responses in diabetes

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Persons with urinary stone disease have an increased risk of fracture yet no guidelines exist to help providers screen or manage these persons for osteoporosis. The underlying cause of skeletal fragility in urinary stone disease is poorly understood. This project proposes to identify persons with urinary stone disease at highest risk of fracture and to understand the skeletal status in persons with urinary stone disease so that early diagnosis and treatment can be instituted to prevent fracture.

PI_NAMEs: GANESAN, CALYANI  (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: Alkalies;Award;Biological Markers;bisphosphonate;bone;bone health;bone imaging;Bone Resorption;bone strength;Calcium;calcium metabolism;Caring;Citrates;Clinic;Clinical;Clinical Investigator;clinically significant;cohort;Collection;comorbidity;Cross-Sectional Studies;Data;Data Set;Dedications;density;Detection;Development;Diagnosis;Disease;Early Diagnosis;Early treatment;Equilibrium;Excretory function;Exhibits;experience;Forteo;Fracture;fracture risk;Funding;Grant;Guidelines;Healthcare Systems;high risk;Hour;Hydroxyproline;Hypogonadism;imaging modality;Imaging Techniques;improved;Kidney Calculi;Knowledge;Measurement;Measures;Mentored Patient-Oriented Research Career Development Award;Mentorship;Monitor;novel;Osteocalcin;Osteogenesis;Osteoporosis;Osteoporotic;Patient Care;patient oriented research;Patient Recruitments;Patients;Peripheral;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Postmenopause;prevent;prospective;Provider;Quality of Care;recruit;Recurrence;Recurrent disease;Research;Research Infrastructure;Research Personnel;Resolution;Risk Factors;Scientist;screening;screening guidelines;Serum;Signal Transduction;skeletal;skill acquisition;skills;Statistical Methods;Thick;Time;Training;treatment guidelines;United States Department of Veterans Affairs;Universities;Urinary Calculi;Urine;Veterans Health Administration;Work;X-Ray Computed Tomography

PROJECT_TITLE: Bone Health in Patients with Urinary Stone Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative This project aims to examine serotonin projections and signaling that regulates food intake by targeting the neural circuits connecting zona incerta and paraventricular thalamus, two brain areas are recently confirmed to be important in the feeding control. Therefore, the proposed studies in this application will help understand the role of the central serotonin system in the regulation of food intake and the involvement of dysfunctional serotonin signaling in overeating and obesity. The results from this project will shed light on a new target in the pharmacological treatment of obesity and eating disorders.

PI_NAMEs: ZHANG, XIAOBING  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;adeno-associated viral vector;Agonist;Animal Behavior;antagonist;Area;Attenuated;Axon;Behavioral Assay;behavioral study;Brain;brain control;brain dysfunction;Brain region;Brain Stem;Chronic;Complex;Data;Depressed mood;Diet;dopaminergic neuron;Dorsal;Eating;Eating Disorders;Electrophysiology (science);experimental study;Fatty acid glycerol esters;feeding;Feeding behaviors;Food;Food deprivation (experimental);Food Intake Regulation;FOS gene;gamma-Aminobutyric Acid;Genetic;Glutamates;Human;Hyperphagia;Hypothalamic structure;immunocytochemistry;immunoreactivity;inducible Cre;Instinct;Label;Measures;Medial;Mediating;Metabolic;motivated behavior;Motivation;Mus;nerve supply;neural;neural circuit;Neural Pathways;Neurons;neurotransmission;novel;Obesity;obesity treatment;optogenetics;patch clamp;Pathway interactions;pharmacologic;Pharmacological Treatment;Physiological;Play;postsynaptic;postsynaptic neurons;presynaptic;raphe nuclei;Regulation;Reporting;response;Rewards;Role;Satiation;Serotonergic System;Serotonin;serotonin receptor;Signal Transduction;Slice;sugar;System;Testing;Thalamic structure;tool;Tracer;Transgenic Mice;transmission process;Weight Gain;Work;zona incerta

PROJECT_TITLE: Serotonin Signaling in Zona Incerta and Paraventricular Thalamus Regulate Feeding Behavior

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cardiovascular;Heart Disease;Lymphatic Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Understanding the regenerative response of the nervous system in models that naturally regenerate is integral to the development of potential therapies for traumatic brain injury and stroke. The proposed studies in the zebrafish seek to investigate the mechanisms through which meningeal lymphatics contribute to adult neurogenesis and regeneration of the nervous system by regulating the immune response and composition of cerebral spinal fluid. Through these studies we will gain novel insights into the mechanisms that underpin the relationship between the lymphatic system and promoting the regenerative response of the central nervous system.

PI_NAMEs: HARRISON, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Ablation;Acute;Address;Adult;adult neurogenesis;American;Animals;Behavior;Biology;Body System;Brain;brain dysfunction;Brain Injuries;Cardiac;cardiac regeneration;cell behavior;Cells;Central Nervous System;Cerebrospinal Fluid;chemokine;Child;Cicatrix;Clinical;Clinical Trials;Cognition;Collaborations;Comprehension;defined contribution;Development;disability;Fluid Balance;Genetic;Goals;healing;Health;Heart;Heart Injuries;Homeostasis;Human;Image;Imaging Techniques;Immune;Immune response;immunoregulation;Impairment;improved;improved outcome;in vivo;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Injury;insight;Investigation;Knowledge;Lead;Leucocytic infiltrate;Lymphangiogenesis;Lymphatic;lymphatic development;Lymphatic System;lymphatic vasculature;lymphatic vessel;Lymphocyte;Mammals;Mass Spectrum Analysis;Mediating;Meningeal lymphatic system;Modeling;Molecular;Motility;Natural regeneration;Nerve Regeneration;Nervous System;neurogenesis;neuron regeneration;Neurons;neurotropic;new technology;novel;Outcome;Pathway interactions;Patient-Focused Outcomes;Pharmaceutical Preparations;Physical therapy;Play;Population;Positioning Attribute;prevent;programs;Publishing;regenerative;regenerative repair;Regenerative response;Rehabilitation therapy;repaired;Research;response;response to brain injury;response to injury;Role;Signal Pathway;Signal Transduction;Skin;Skin Tissue;Specific qualifier value;Speech;Stroke;Symptoms;System;Systems Development;TBI Patients;TBI treatment;Techniques;Testing;time use;Tissue Model;tissue regeneration;tissue repair;Tissues;tool;trafficking;transcriptomics;Transgenic Organisms;Traumatic Brain Injury;Traumatic injury;United States;Vascular Endothelial Growth Factor C;Vertebrates;Vision;Visualization;wasting;Work;young adult;Zebrafish;zebrafish development

PROJECT_TITLE: Lymphatic Support of Neurogenesis and regeneration


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE Advances in diabetes technology such as continuous glucose monitors (CGM) have the potential improve health outcomes for youth with type 1 diabetes, but adolescents are the least likely to use CGM, are at relatively high risk for underutilizing or discontinuing this technology, and access is challenged by significant health disparities. This project proposes to pilot an intervention incorporating behavioral strategies to optimize CGM use and reduce related psychosocial barriers. The findings of this pilot work will initiate a trajectory of research responsive to the needs of young adolescents, including youth from historically underrepresented racial and ethnic backgrounds and youth with public insurance, related to new diabetes technologies with significant potential to improve health outcomes and clinical diabetes education and care.

PI_NAMEs: STREISAND, RANDI  (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: acceptability and feasibility;access disparities;Acute;Address;Adherence;Adolescence;Adolescent;adolescent health;African American;Age;age group;Attention;Behavior Therapy;Behavioral;Black race;Caring;Certification;Chronic;Clinical;Communication;Complex;Conflict (Psychology);Continuous Glucose Monitor;cost;dashboard;Data;design;Deterioration;Development;Devices;diabetes distress;diabetes education;Diabetes Mellitus;diabetes self-management;Diagnosis;Disease;Distress;Education;Educational process of instructing;Educational Technology;efficacy evaluation;eligible participant;Ensure;ethnic minority;Ethnic Origin;expectation;experience;Family;family support;follow-up;Glucose;glycemic control;Goals;group intervention;Health;health disparity;Health Personnel;high risk;Hispanic;Household;Hyperglycemia;Hypoglycemia;improved;Income;innovation;Insulin;Insulin-Dependent Diabetes Mellitus;Insurance;Intervention;Interview;Joints;Knowledge;Low income;Measures;Medical;Motivation;Not Hispanic or Latino;novel;Outcome;Outcome Assessment;parent-adolescent communication;Parents;Participant;peer;peer support;Personal Satisfaction;Pilot Projects;pilot trial;Population Heterogeneity;Positioning Attribute;primary outcome;Problem Solving;Process;psychosocial;public health insurance;Race;racial minority;Randomized;randomized trial;randomized, clinical trials;Recommendation;recruit;Reduce health disparities;Regimen;Reporting;Research;Resources;response;Risk;routine care;satisfaction;secondary outcome;Site;skills;Social support;Source;Specialist;standard care;Structure;Technology;Telemedicine;Time;uptake;Work;Youth

PROJECT_TITLE: Optimizing Technology Uptake and Use in Hard to Reach Adolescents with Type 1 Diabetes

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Orphan Drug;Patient Safety;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative  Follow-up imaging for glioblastoma patients is challenging to interpret due to subjectivity in evaluating disease state and overlap between treatment effects and tumor progression. More objective follow-up criteria are vital for sensitive and accurate monitoring of glioblastoma patients after initial treatment to ensure proactive management of disease and accurate characterization of tumor recurrence. This research proposal will develop user-friendly quantitative software for lesion segmentation and disease-state assessment, providing unbiased metrics for post-treatment patient monitoring and guidance of management decisions in clinical and research settings.

PI_NAMEs: RAMESH, KARTHIK  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: 3-Dimensional;Address;Adjuvant Chemotherapy;Adopted;Adoption;Affect;Aftercare;aggressive therapy;Algorithms;automated image analysis;automated segmentation;Brain;Brain Neoplasms;Caring;chemoradiation;Classification;Clinical;Clinical Data;clinical decision-making;Clinical Trials;cohort;Collaborations;Complex;Computer software;Control Groups;convolutional neural network;Data;Data Set;Databases;deep learning;Dependence;Diagnosis;Disease;disease classification;Disease Management;Disease Progression;Dose;efficacy evaluation;Ensure;Environment;Evaluation;Excision;Face;follow-up;Future;Glioblastoma;Goals;High Performance Computing;Image;Image Analysis;Imaging Device;imaging modality;implementation framework;improved;Information Systems;Interobserver Variability;Intervention;Intuition;Language;Lesion;Longterm Follow-up;machine learning algorithm;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;Manuals;Measurement;Medical Imaging;Methods;Monitor;multidisciplinary;network architecture;Newly Diagnosed;novel therapeutics;Operative Surgical Procedures;Patient Care;Patient imaging;Patient Monitoring;Patient-Focused Outcomes;Patients;personalized medicine;Pharmaceutical Preparations;Phase;Physicians;Play;prediction algorithm;predictive tools;Progression-Free Survivals;quantitative imaging;Radiation Oncologist;Radiation therapy;Radiology Specialty;Reader;Recurrence;recurrent neural network;Recurrent tumor;Reporting;Research;Research Proposals;Resources;response;Role;Scanning;segmentation algorithm;Slice;standard of care;Standardization;Structure;success;System;Testing;tool;Training;treatment effect;treatment strategy;tumor;tumor progression;Tumor Volume;two-dimensional;United States;Universities;user-friendly;Validation

PROJECT_TITLE: Automated imaging analysis tools to guide clinical decision making in brain tumor patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-Y(20)L]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Prevention;Women's Health Research

PHR: Narrative We will develop an ultrafast and very high resolution system for tomographic ultrasound and photoacoustic imaging. This system can enhance the sensitivity of breast lesion detection and will be used to reduce benign biopsies through the methods developed here.

PI_NAMEs: FERRARA, KATHERINE W (contact);POPLACK, STEVEN

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: 3-Dimensional;absorption;Address;Algorithms;angiogenesis;Benign;Biopsy;Blood;Blood flow;Breast;Breast Cancer Detection;Breast Cancer Model;Breast Cancer Risk Factor;breast imaging;breast lesion;Breast Magnetic Resonance Imaging;breast scanner;Clinical;Clutterings;Complement;contrast enhanced;contrast imaging;Contrast Media;convolutional neural network;cost;Data;Data Science;Data Set;Dedications;design;Detection;Development;Diagnostic Factor;Diagnostic Imaging;Engineering;Fatty acid glycerol esters;Floor;Frequencies;Functional Imaging;Goals;Hemoglobin;Human body;human study;Hypoxia;Image;imaging modality;imaging system;improved;Individual;interest;intravenous injection;Lasers;Lesion;Literature;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Gland Parenchyma;Mammary Neoplasms;Maps;Methods;Modeling;Morphology;Motor;mouse model;Mus;Noise;Optics;optoacoustic tomography;Partner in relationship;Patient imaging;Performance;photoacoustic imaging;Population;Predictive Value;premalignant;Prognostic Factor;Radiation;real-time images;Real-Time Systems;Recommendation;Reporting;Resolution;Risk;Rodent Model;Rotation;Scanning;screening;Sensitivity and Specificity;Signal Transduction;Site;Specificity;Speed;standard of care;structural imaging;System;Techniques;Technology;technology development;technology validation;Testing;Time;Tissues;tomography;Transducers;transmission process;tumor;Ultrasonic Tomography;Ultrasonography;ultrasound;Update;vector;Visualization;volunteer;Woman

PROJECT_TITLE: Quantitative volumetric ultrasonic and photoacoustic tomography

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Machine Learning and Artificial Intelligence

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Project Narrative  The rapid rise in antibiotic resistance coupled with a dwindling antibacterial pipeline, particularly for Gram- negative pathogens, has collectively contributed to multi-drug resistant infections being deemed one of the biggest threats to global health. While recent advances have led to an understanding of the physicochemical traits guiding compound entry in Gram-negative bacteria, promiscuous compound efflux still remains poorly understood and is detrimental to antibacterial activity. This proposal seeks to define features necessary for compound recognition and expulsion by efflux pumps in E. coli and to codify these physicochemical properties into actionable guidelines for engineering efflux liabilities out of antibacterial candidates.

PI_NAMEs: ULRICH, REBECCA  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Bacterial Infections;Basic Science;Biological Assay;Cells;chemical property;Classification;Clinical;Collection;combat;Coupled;Data Set;design;design and construction;Development;drug candidate;Drug Kinetics;drug resistant bacteria;efficacy evaluation;efficacy study;efflux pump;Engineering;Escherichia coli;Evaluation;Excision;FDA approved;global health;Gram-Negative Bacteria;Guidelines;improved;In Vitro;in vivo;Infection;Informatics;inhibitor;innovation;insight;Libraries;Measures;Membrane;Modeling;Modification;mouse model;Multi-Drug Resistance;Mus;natural product inspired;Nitrogen;novel;Outcome;pathogen;Pathogenicity;Predisposition;prevent;Property;Quinolones;random forest;Research;Resistance;Running;Shapes;Side;small molecule;Testing;Therapeutic;tool;Toxic effect;trait;Validation;Work

PROJECT_TITLE: Exploring the physicochemical properties governing compound efflux in Gram-negative bacteria


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: BERKELEY

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: In the classical view of chronic or excess glucocorticoid exposure, glucocorticoids convey their signals through an intracellular glucocorticoid receptor that acts with various coregulator proteins to modulate the transcription of specific target genes, which induce insulin resistance, a risk of type 2 diabetes. Here, we will examine a novel model in which glucocorticoid receptor coregulator, Ehmt2, specifically activates genes that promote insulin sensitivity to limit the insulin resistance caused by the glucocorticoid receptor acting with other coregulators. The knowledge gained from this revolutionary model will provide novel  therapeutic insights into treating type 2 diabetes.

PI_NAMEs: WANG, JEN-CHYWAN  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Adipose tissue;Affect;Attenuated;Binding;Chronic;Complex;Docking;Equilibrium;experimental study;Extracellular Signal Regulated Kinases;Family;gene repression;Genes;genetic corepressor;Genetic Transcription;Genomics;Glucocorticoid Receptor;glucocorticoid-induced orphan receptor;Glucocorticoids;Glucose;Glucose Clamp;glucose production;Hepatic;hepatic gluconeogenesis;Hyperinsulinism;insight;insulin regulation;Insulin Resistance;insulin sensitivity;insulin signaling;knock-down;Knowledge;Liver;Lysine;MAPK3 gene;Metabolic;Metabolic Diseases;Mitogen-Activated Protein Kinases;Modeling;Mus;Mutation;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;overexpression;Peripheral;Phenotype;Phosphoric Monoester Hydrolases;Proteins;recruit;Regulation;resistance gene;Response Elements;Risk;Role;Signal Transduction;Site;Skeletal Muscle;Stress;Testing;Tissues;Transcription Coactivator;transcription factor;Transcriptional Activation;transcriptome sequencing

PROJECT_TITLE: Glucocorticoid Receptor Coregulators and Insulin Sensitivity

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer;Neurosciences;Skin Cancer

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Cellular shape change is a fundamental characteristic of cells, key to development, physiology, and pathology. The morphogen netrin promotes neuronal development and cancer progression, yet we know little about how cells interpret netrin into shape changes. Our work exploits developing neurons and migrating melanoma cells as model systems to examine how netrin alters cellular shape during development and metastasis.

PI_NAMEs: GUPTON, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TITLE: Coordinated Cytoskeletal Dynamics and Membrane Remodeling in Cellular Shape Change

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Vaccine Related

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE HIV infection can be treated and to some extent prevented with effective medications, but this alone has not resulted in sufficient progress worldwide to expect an end to the HIV epidemic. In addition, persons who are infected with HIV, even if they are receiving effective medication treatment, continue to have health consequences that likely persist for life; in many cases, they remain at risk for other infectious complications as well. The Case CTU plans to contribute to research to improve the options to deliver HIV treatment, to find an effective and universal HIV vaccine, to achieve long-term control of HIV in infected persons, and to understand lethal infectious complications such as tuberculosis and hepatitis.

PI_NAMEs: JACOBSON, JEFFREY M. (contact)

PROGRAM_OFFICER_NAME: SMITH, BARIATU

PROJECT_TERMS: Address;Adult;Africa;African;AIDS clinical trial group;AIDS prevention;Anti-Retroviral Agents;antiretroviral therapy;Area;Basic Science;Biopsy;Cerebrospinal Fluid;Clinical;clinical center;clinical infrastructure;Clinical Management;Clinical Research;clinical research site;clinical trial analysis;Clinical Trials;Clinical Trials Cooperative Group;Clinical Trials Unit;Collaborations;Databases;determinants of treatment resistance;Development;Disease;Doctor of Philosophy;Enrollment;Epidemic;Evaluation;expectation;experience;Faculty;Funding;Grant;Health;Hepatitis;Hepatitis C Therapy;high risk;HIV;HIV Antibodies;HIV Infections;HIV prevention trial;HIV vaccine;HIV Vaccine Trials Network;HIV/TB;Immune response;Immunization;Immunocompetence;Immunologic Monitoring;Immunology;Immunotherapy;improved;Inflammation;Infrastructure;interest;International;Joints;Laboratories;Leadership;Leukapheresis;Life;Link;Logistics;lymph nodes;member;Metabolic;Monitor;Monitoring Clinical Trials;National Institute of Allergy and Infectious Disease;notch protein;novel;Organ;outreach program;participant enrollment;Pathogenesis;Performance;Persons;PET/CT scan;Pharmaceutical Preparations;Phase;Population;Positioning Attribute;Predisposition;prevent;Prevention;Prevention Research;Productivity;Protocols documentation;recruit;Research;Research Personnel;Risk;Role;Site;Special Population;targeted treatment;Tissue Sample;Translational Research;translational research program;treatment trial;Tuberculosis;Uganda;United States National Institutes of Health;Universities;vaccination strategy;vaccine response;vaccine trial;volunteer

PROJECT_TITLE: Case Clinical Trials Unit


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention

PHR: PROJECT NARRATIVE The New York City – Newark metropolitan area is the area of the U.S. most affected with over 130,000 people living with HIV and over 2000 newly diagnosed with HIV each year. The WCM-NJMS CTU will conduct studies of HIV treatment and HIV prevention to advance the field. WCM-NJMS CTU investigators are key leaders in the field who are shaping the research agendas of the DAIDS networks.

PI_NAMEs: GULICK, ROY M. (contact)

PROGRAM_OFFICER_NAME: MEANS, DAVID MICHAEL

PROJECT_TERMS: Address;Affect;African American population;AIDS prevention;American;Anti-Retroviral Agents;Area;Back;Clinical Investigator;Clinical Research;clinical research site;Clinical Trials Network;Clinical Trials Unit;Collaborations;Communication;Communities;community advisory board;community engagement;community research;comorbidity;Core Facility;cost;County;data quality;Disease;Enrollment;Epidemic;ethnic diversity;experience;Geography;Grant;Health;Hepatitis;HIV;HIV Infections;HIV prevention trial;HIV Seroprevalence;HIV/AIDS;Home;Infrastructure;Island;Joints;Laboratories;Leadership;Long Island;medical schools;Medicine;Mentors;metropolitan;National Institute of Allergy and Infectious Disease;Neighborhoods;Neurologic;New Jersey;New York City;Newly Diagnosed;next generation;Participant;participant enrollment;Patients;Performance;Persons;Pharmaceutical Preparations;Population Heterogeneity;pre-exposure prophylaxis;Prevention Research;Prevention strategy;Prevention trial;primary care clinic;Procedures;Productivity;quality assurance;racial diversity;Records;Research;Research Personnel;Research Subjects;Research Support;Risk;Scientific Advances and Accomplishments;Seroprevalences;Shapes;Site;synergism;Therapeutic;Training;treatment strategy;treatment trial;Tuberculosis;United States;Woman;Work

PROJECT_TITLE: Weill Cornell Medicine - Rutgers New Jersey Medical School Clinical Trials Unit


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: NARRATIVE To identify new therapeutic targets against MRSA, we will study the trafficking of surface proteins, which are essential for S. aureus colonization and disease pathogenesis. Our proposal will reveal the mechanisms of septal membrane assembly, regulated cleavage of YSIRKxxxGxxS precursors at septal membranes and precursor activation of SecYEG translocons for their secretion into the cross-wall compartment. Our studies are expected to provide insights into the mechanisms of surface protein secretion and assembly in other drug- resistant bacteria, including vancomycin-resistant enterococci, penicillin-resistant pneumococci and antibiotic- resistant Clostridium difficile.

PI_NAMEs: MISSIAKAS, DOMINIQUE M. (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Antibiotic Resistance;Binding;C-terminal;catalyst;Cell Cycle;Cell Cycle Completion;Cell division;Cell Separation;Cell Wall;Cells;Communities;Complex;Defect;Deposition;Diglycerides;Disease;drug resistant bacteria;Escherichia coli;Exhibits;extracellular;Genus staphylococcus;Glycolipids;Gram-Positive Bacteria;Hospitals;In Vitro;in vivo;Infection;insight;Link;Lipids;lipoteichoic acid;Measures;Membrane;membrane assembly;Membrane Proteins;methicillin resistant Staphylococcus aureus;Modeling;mortality;mutant;Mutation;new therapeutic target;Pathogenesis;Pathway interactions;Penicillin Resistance;Peptide Signal Sequences;Peptides;Peptidoglycan;Phosphatidylglycerols;polyglycerol;polypeptide;Process;Property;Protein Precursors;Protein Secretion;Regulation;Reporting;resistant Clostridioides difficile;Role;Signal Transduction;Site;SLEB1 gene;sortase;Sorting;Staphylococcus aureus;Streptococcus pneumoniae;Structure;Surface;temperature sensitive mutant;Testing;trafficking;Vancomycin resistant enterococcus;Variant;Virulence

PROJECT_TITLE: Surface Proteins of Gram-Positive Bacteria

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


FUNDING_MECHANISM: OTHERS

ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: My research can revolutionize how VA patients with amputations connect their external prosthetic device to their residual limb, helping them to maximize their functional recovery and their quality of life. <<My work ranges from basic bench-top science, to trials with translational animal models, and to FDA monitored clinical trials with the goal of bringing safe, FDA approved percutaneous osseointegrated (OI) devices to this deserving patient population. The concept of OI is based on the ability of human bone cells to attach to a metal surface. OI has been used for decades to anchor dental prosthetic devices. More recently, a common paradigm in orthopaedics with hip, knee, and shoulder arthroplasties, uses OI to anchor an endoprosthesis surgically implanted into the bone and within the body. My research takes me outside this paradigm. I engineer percutaneous OI devices, which require a load-bearing metal post to be connected to the OI endoprosthesis, passing permanently through the skin to be connected to the distal componentry outside of the body.

PI_NAMEs: BACHUS, KENT N. (contact)

PROJECT_TERMS: Adoption;Amputation;Amputees;Animal Model;Animals;Articular Range of Motion;Award;battlefield injury;Biomechanics;Body Weight;bone;bone cell;Cadaver;career;Caring;Climacteric;Clinical;Clinical Trials;combat;Commercial grade;Coupled;daily functioning;Data;Dental;Dental Prosthesis;Dermatitis;design;Device or Instrument Development;Devices;Distal;Docking;Effectiveness;Engineering;European;Event;experience;Fatigue;FDA approved;Feasibility Studies;Femur;Fracture Fixation;Freezing;Friction;functional improvement;functional loss;Gender;Goals;Handedness;Healthcare Systems;Heterotopic Ossification;Hip region structure;Human;humerus;Hyperhidrosis disorder;Implant;Infection prevention;instrumentation;Knee;Label;Left;Length;limb amputation;limb loss;manufacture;Measures;Mechanics;Metals;Modification;Monitoring Clinical Trials;Morphology;morphometry;Motion;Multi-Institutional Clinical Trial;multidisciplinary;muscle reinnervation;novel;Operative Surgical Procedures;Orthopedics;Osseointegration;Pain;patient oriented;patient population;Patients;Population;Porosity;Positioning Attribute;pre-clinical;preclinical development;Prevalence;professor;Property;Prosthesis;Quality of life;Recording of previous events;Recovery of Function;Replacement Arthroplasty;Reporting;Research;residual limb;Residual state;Safety;Science;Scientist;Series;Shoulder;Skin;soft tissue;stem;Stomas;Surface;System;Technology;Testing;Titanium;Trauma;United States;Upper Extremity;Veterans;Weight-Bearing state;Woman;Work

PROJECT_TITLE: RR&D Research Career Scientist Award Application

STUDY_SECTION_NAME: Research Career Scientist[RRD7]


NIH_SPENDING_CATS: Genetics

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE The first steps in gene expression – those encompassing the synthesis of RNA – touch every process in the cell and can be compromised in disease, including disease arising from defects in the RNA synthesis machinery itself. The proposed studies in model organisms such as Baker’s yeast, fission yeast, and Drosophila allow a deep understanding of how and where gene expression begins in eukaryotes involving factors conserved across eukaryotes, including humans. In parallel, experiments illuminate questions universal to eukaryotic cells: how the machinery for RNA synthesis navigates the genome and how connections between RNA synthesis and transcript processing and chromatin remodeling come about.

PI_NAMEs: KAPLAN, CRAIG  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Active Sites;Amino Acids;Biochemical;Biological Assay;Biology;Cell Physiology;Cells;Chemicals;Chromatin;chromatin remodeling;Complex;Coupling;Defect;Disease;DNA;Drosophila genus;Enzymes;Eukaryota;Eukaryotic Cell;Event;experimental study;Fission Yeast;Gene Expression;Genetic;Genetic Transcription;Genome;genome-wide analysis;Human;Individual;insight;Link;model organism;Modeling;Modification;Mutation;mutation screening;novel;Polymerase;Positioning Attribute;Process;promoter;Proteins;RNA;RNA chemical synthesis;RNA Polymerase II;RNA Processing;RNA Splicing;Role;Running;Saccharomyces cerevisiae;Syndrome;System;Testing;Touch sensation;Transcript;Transcription Initiation Site;transcriptome;Work

PROJECT_TITLE: Mechanisms of RNA Polymerase II transcription

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_CITY: HANOVER

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Narrative The extent to which cancer tissue is completely removed during surgery of intracranial tumors is an important prognostic indicator of local recurrence and overall patient survival; however, current and new approaches designed to guide resection have major shortcomings. To solve this problem, we are advancing a new strategy for surgical guidance that aims to use injected optical contrast agents to reproduce the diagnostic information provided by pre-operative contrast-enhanced MRI images. Contrast-enhanced MRI imaging is the standard reference for diagnosis, surgical navigation and post-treatment monitoring of intracranial tumors; and thus, transferring this important information into the visual surgical field will be a major development to help surgeons maximize tumor clearing.

PI_NAMEs: DAVIS, SCOTT C (contact);ROBERTS, DAVID W

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;Aftercare;alternative treatment;analog;Anatomy;Animal Model;Animals;Behavior;Biodistribution;Brain;Brain Neoplasms;brain tumor resection;candidate identification;Caring;Characteristics;Clinical;clinical imaging;Clinical Management;clinical translation;Compensation;contrast enhanced;Contrast Media;Couples;Craniotomy;Custom;Data;Data Sources;design;Development;Devices;Diagnosis;Diagnostic;Dose;Drug Kinetics;Evaluation;Excision;experience;Family suidae;Fluorescence;fluorescence-guided surgery;Fluorescent Dyes;follow-up;Gadolinium;Glioma;Head;Human;Human Biology;Image;image registration;improved;improved outcome;Incubated;Intracranial Neoplasms;Investigation;Kinetics;Label;Lead;lead candidate;Literature;Magnetic Resonance Imaging;Malignant Neoplasms;Managed Care;Microscope;Modality;Modeling;Modernization;Molecular;Molecular Abnormality;Monitor;Monitoring for Recurrence;neoplastic cell;neurosurgery;Normal tissue morphology;novel;novel strategies;Operative Surgical Procedures;optical imaging;Optics;Patient-Focused Outcomes;Patients;Play;PPIX;Preparation;Procedures;prognostic indicator;Progression-Free Survivals;Protocols documentation;Recurrence;Reference Standards;Resolution;Role;Signal Transduction;standard of care;Structure;Surgeon;Surgical Instruments;targeted agent;Time;Tissues;tomography;tool;tumor;tumor heterogeneity;Tumor Tissue;tumor xenograft;ultrasound;Update;uptake;Vision;Visual;Visual Fields;whole body imaging;Xenograft Model

PROJECT_TITLE: Optical Analogs to MRI Contrast Agents for Surgical Guidance of Brain Tumor Resection

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: The proposed CDA-2 will provide Dr. Kornblith with the training, expertise, and hands-on experience necessary to advance research on cognitive rehabilitation for aging Veterans with traumatic brain injury (TBI), and increase access to such treatment. Using technology to deliver effective treatment for cognitive problems associated with TBI to Veterans at home may result in improved daily functioning and increased access to health care for the growing population of aging Veterans with history of TBI. The successful completion of this project may also increase older Veterans’ ability to participate in research through increased understanding of the effect of in-home research opportunities on recruitment and retention. Additionally, the evidence gathered from this study may be used in future research studying home-based cognitive rehabilitation treatments for Veterans using telehealth technology.

PI_NAMEs: KORNBLITH, ERICA S (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;affective disturbance;Age;Aging;Area;Attention;attentional control;Award;Caregiver support;Characteristics;Chronic;chronic pain;Clinic;Clinical;Clinical Trials;Cognition;Cognitive;cognitive benefits;cognitive function;cognitive performance;cognitive rehabilitation;cognitive training;Cohort Studies;Collection;comparative efficacy;Complex;daily functioning;Data;Dementia;depressive symptoms;Dropout;Educational Intervention;effective therapy;emotion regulation;Emotional;emotional functioning;Enrollment;Equipment and supply inventories;evidence base;Evidence based program;executive function;experience;Face;Family;Feedback;Functional disorder;Functional impairment;functional outcomes;Future;General Population;Goals;Health;health care availability;health goals;Health Services Accessibility;Health Technology;Healthcare;High Prevalence;Home;human old age (65+);Improve Access;improved;Informal Social Control;innovation;Intervention;Manuals;Measures;Mental Depression;Mentors;Methods;military veteran;mindfulness;Moods;neurobehavioral;Neurocognitive;normal aging;older adult;Outcome;Outcome Measure;Participant;Patient Self-Report;Persons;Phase;Pilot Projects;Population;Post-Traumatic Stress Disorders;Prevalence;programs;Protocols documentation;psychoeducation;Randomized;randomized trial;Recording of previous events;recruit;rehabilitation research;Rehabilitation therapy;Reporting;Research;research study;response;Risk;rural area;Sample Size;Selection Criteria;sex;Standardization;Symptoms;TBI Patients;Technology;telehealth;Telemental;Testing;tool;Training;Transportation;Traumatic Brain Injury;urban area;Veterans;Veterans Health Administration;Videoconferencing;Work

PROJECT_TITLE: Rehabilitation of Executive Function in Aging Veterans with History of TBI

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


NIH_SPENDING_CATS: Cancer

ORG_CITY: BOSTON

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: PROJECT NARRATIVE  KRAS is one of the most prevalent and vicious cancer proteins, yet no drugs are available to inhibit its pathologic activity in human cancers. We have discovered that an all-hydrocarbon “stapled” peptide modeled after the KRAS-interacting helix of SOS1, a natural KRAS agonist, can inhibit oncogenic KRAS signaling by competitive dissociation of the SOS1/KRAS complex and, unexpectedly, by directly and independently blocking KRAS nucleotide association by an unknown mechanism. By combining the synergistic and interdisciplinary expertise of the Engen and Walensky laboratories, we aim to achieve new insight into the structure-function mechanisms of KRAS modulation by the SOS1 protein and SOS1- derived stapled peptides, and thereby advance a novel therapeutic approach for disarming KRAS in human cancer.

PI_NAMEs: WALENSKY, LOREN DAVID;WALES, THOMAS EDWARD (contact)

PROGRAM_OFFICER_NAME: AMIN, ANOWARUL

PROJECT_TERMS: Agonist;Alanine;alpha helix;analytical method;Benchmarking;Binding;Binding Sites;Biochemical;Biology;cancer cell;Catalytic Domain;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Chemicals;Clinical;clinical translation;Colon Carcinoma;Complex;Deuterium;Dissociation;efficacy testing;Endocytosis;enhancing factor;Epitopes;Extracellular Signal Regulated Kinases;Family;Frequencies;gain of function;Gene Amplification;Generations;Goals;GTP Binding;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Homologous Gene;Human;human model;Hydrocarbons;Hydrogen;Impairment;in vivo;in vivo evaluation;inhibitor;innovation;insight;KRAS oncogenesis;KRAS2 gene;Laboratories;Lead;Libraries;Link;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of thyroid;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;mimicry;Modality;Modeling;Molecular Conformation;Monitor;Motility;mouse model;Mutagenesis;mutant;Mutation;nanomolar;next generation;novel;novel therapeutic intervention;Nucleotides;Oncogenic;Pathologic;Pathway interactions;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Protein Conformation;Protein Family;Proteins;Proto-Oncogenes;prototype;RAS inhibition;ras Proteins;Regulation;Reporting;Research;Scanning;Signal Transduction;small molecule;Specificity;stapled peptide;Structure;synergism;targeted treatment;Testing;Therapeutic;therapeutic target;translational approach;tumor;uptake;Variant;Work

PROJECT_TITLE: Conformational Regulation and Therapeutic Targeting of Oncogenic KRAS


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Depression;Genetics;Human Genome;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE PUBLIC HEALTH RELEVANCE STATEMENT: Psychiatric disorders including major depressive disorder (MDD) are widespread, yet they are difficult to diagnose and treat due to a lack of available biomarkers. The discovery of biomarkers whereby those at high risk for psychiatric disorders can be identified would lead to optimized patient care, improved patient outcomes, and more efficient allocation of resources. As such, the proposed research aiming to identify epigenetic signals from brain tissue samples associated with psychiatric disorders, especially MDD, and their correlation to epigenetic signals from peripheral tissues is expected to provide a novel approach that can inform the prevention of MDD. Further, it is likely to also facilitate the development of treatments for patients who experience MDD.

PI_NAMEs: SHINOZAKI, GEN  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Age;Amygdaloid structure;Archives;Autopsy;Biological Markers;biomarker discovery;Blood;Brain;brain cell;Brain Diseases;Brain region;brain tissue;cell type;Cells;cohort;Collaborations;Collection;Communities;Complex;Data;Data Set;Databases;Depressed mood;Development;Diagnosis;Disease;DNA;DNA Databases;DNA Methylation;Environment;Epigenetic Process;epigenome;epigenomics;Excision;experience;Fluorescence-Activated Cell Sorting;Functional disorder;Future;genome-wide;genome-wide analysis;Genomic Segment;Goals;high risk;Hippocampus;histone modification;Human;human tissue;improved;Individual;innovation;interest;Iowa;large datasets;Major Depressive Disorder;Measures;Mental disorders;Methylation;methylation pattern;MicroRNAs;Modification;Neuroglia;Neurons;neuropathology;neurosurgery;Neurosurgical Procedures;novel;novel strategies;Outcome;Pathogenesis;Pathology;Patient Care;Patient-Focused Outcomes;Patients;Peripheral;Prefrontal Cortex;Prevention;Process;prospective;public health relevance;Regional Disease;Research;Research Personnel;research study;Resected;Resource Allocation;Resources;Saliva;Sample Size;Sampling;sex;Signal Transduction;specific biomarkers;stressor;Swab;Testing;therapy development;Time;Tissue Sample;Tissues;trend;Work

PROJECT_TITLE: Identification of Epigenetics Correlates between Brain and Peripheral Tissues

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Prevention

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: This research grant is designed to determine whether chronic treatment with mirabegron, a β3 adrenergic receptor agonist approved for treatment of over active bladder, improves metabolic homeostasis in prediabetic, obese, research participants. We will also investigate the underlying mechanisms for improved β-cell function and insulin sensitivity by mirabegron treatment, which we recently demonstrated. There is a tremendous need for new approaches to fight the obesity and type 2 diabetes epidemic, and this research is thus highly relevant to human health.

PI_NAMEs: KERN, PHILIP A (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: Adipocytes;adipokines;Adipose tissue;Adrenergic Agonists;Adrenergic Receptor;adult obesity;Affect;Agonist;Anti-diabetic Drugs;Beta Cell;bile acid metabolism;Biochemical;blood glucose regulation;Body Weight decreased;Brown Fat;Cell Physiology;cell type;Cells;Chronic;clinically relevant;combat;Conditioned Culture Media;Consumption;design;Development;Diabetes Mellitus;diabetic;Epidemic;exosome;Fatty acid glycerol esters;FDA approved;Fiber;Fibrosis;fighting;functional improvement;Gene Expression;Glucose;glucose metabolism;glucose tolerance;glucose uptake;Glycosylated hemoglobin A;Health;Homeostasis;Human;human study;improved;In Vitro;Inflammation;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;interest;Lipids;Lipolysis;Mammals;Measures;Mediating;Metabolic;Metabolic syndrome;Methods;MicroRNAs;mRNA Expression;Mus;Muscle;Muscle Cells;Muscle function;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Obesity;obesity treatment;older adult;oral glucose tolerance;Organ;Overactive Bladder;Participant;Peripheral;Pharmaceutical Preparations;pharmacologic;Physiological;Plasma;Play;Prediabetes syndrome;prevent;Property;Proteins;randomized placebo controlled trial;Research;Research Project Grants;response;Rodent;Role;Skeletal Muscle;Smooth Muscle;Structure of beta Cell of islet;subcutaneous;Therapeutic;Thinness;Tissues;transcriptome sequencing;uncoupling protein 1;Volatile Fatty Acids

PROJECT_TITLE: Mechanisms for activation of beige adipose tissue in humans

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Narrative: The proposed research is relevant to the public health because it interrogates the mechanisms underlying neural developmental deficits with key pathogenic roles in Huntington’s disease. More specifically, it will define what processes adversely influence the elaboration of interneurons, how their reductions impact the maturation of relevant brain circuits, and whether these deficits yield neuronal species more susceptible to stressors. Accordingly, this research would uncover mechanistic cascades that will provide the substrate for the development of therapeutic paradigms aimed at modifying disease progression, which is relevant to the goals of NIH’s overall strategic mission.

PI_NAMEs: MOLERO, ALDRIN ENRIQUE (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Acute;Adult;American;Automobile Driving;biological adaptation to stress;Biological Assay;Biological Markers;Biosensor;Brain;causal variant;Cell Cycle;Cell Cycle Arrest;Cells;Cellular Stress;Cognitive;comorbidity;Complement;Corpus striatum structure;critical period;Data;Development;Disease;disease model;Disease Progression;DNA Damage;effective therapy;Electrophysiology (science);Equilibrium;Event;excitotoxicity;Exhibits;Exposure to;Gene Expression;Gene Modified;Generations;Genetic;genetic approach;Genotoxic Stress;genotoxicity;Goals;Huntington Disease;Huntington gene;Impairment;In Vitro;in vivo;Inherited;innovation;Interneurons;Length;Life;loss of function;Maps;Mediating;Methodology;Methods;Microscopy;middle age;migration;Mission;Modeling;Molecular;Molecular Profiling;motor deficit;mouse model;mutant;Mutation;Nervous System Disorder;neural;Neurodegenerative Disorders;neurodevelopment;Neurons;novel;novel therapeutic intervention;Onset of illness;optogenetics;Output;patch clamp;Pathogenesis;Pathogenicity;Pathway interactions;Phase;Play;polyglutamine;precursor cell;Predisposition;Process;Production;progenitor;Proliferating;Proteins;Public Health;Radial;Reporter;Research;response;Risk;Role;Slice;Slide;Stress;Stress and Coping;stressor;System;Techniques;therapeutic development;Therapeutic Intervention;Therapeutic Research;Time;United States National Institutes of Health;Work

PROJECT_TITLE: The Pathogenic Role of Interneurons in Huntington's Disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: AUGUSTA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Project narrative  Liver cancer, especially hepatocellular carcinoma (HCC), is the fastest growing cancer in US with no effective treatment. We are conducting research to identify HCC-specific T cell receptor (TCR) that can be used to engineer human T cell to become highly effective TCR-Ts to kill tumor cells without causing significant toxicity to normal cells. This proposal allows us to gather sufficient data to apply for clinical trials and eventually leads to new immunotherapy for hepatocellular carcinoma.

PI_NAMEs: HE, YUKAI  (contact)

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: Address;Adjuvant Therapy;Adult;Affinity;Allogenic;Antigens;antitumor effect;Autologous;Autologous Dendritic Cells;Avidity;Binding;Cancer Etiology;CD8 Antigens;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cessation of life;Cetuximab;Chimeric Proteins;clinical trial readiness;Clinical Trials;Clone Cells;Cross Reactions;cross reactivity;cytotoxicity;Data;Dendritic Cells;Disease;effective therapy;Engineering;Epidermal Growth Factor Receptor;Epitopes;Excision;FDA approved;Future;Goals;Haplotypes;Health;hepatocellular carcinoma cell line;Hepatocyte;HepG2;HLA-A2 Antigen;Human;Human Engineering;Hybridomas;Immunization;Immunotherapy;In Vitro;in vivo;Incidence;Interleukin-15;Lesion;Libraries;Light;Liver;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant Neoplasms;man;Memory;Methods;Mus;neoplasm immunotherapy;neoplastic cell;Normal Cell;Normal tissue morphology;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;patient derived xenograft model;Patients;Peptides;Pharmaceutical Preparations;Physiologic pulse;PIK3CG gene;Primary carcinoma of the liver cells;Process;Protocols documentation;Recurrence;Research;response;Safety;safety study;Scanning;Signal Transduction;single cell sequencing;Specificity;stem;stemness;success;System;T-Cell Activation;T-Cell Proliferation;T-Cell Receptor;T-Cell Receptor Genes;T-cell receptor repertoire;T-Lymphocyte;Testing;Tissues;Toxic effect;Transgenic Organisms;tumor;Tumor Tissue;vaccination strategy;Vaccines;Xenograft Model;α-Fetoproteins

PROJECT_TITLE: TCR engineering of human T cells for immunotherapy of hepatocellular carcinoma

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ORG_CITY: PHILADELPHIA

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Solitary Fibrous Tumors (SFTs) are an understudied tumor with an unclear pathogenesis, about a fifth of cases become malignant and unresponsive to treatments. There are no known recurring mutations in SFTs other than an intra-chromosomal inversion that leads to a gene fusion between NAB2 and STAT6, which produces a chimeric protein with an unknown function. Understanding the role the NAB2-STAT6 fusion protein plays in gene expression will lead to greater understanding of SFTs development and progression to malignancy, and may elucidate therapeutic targets for the treatment of SFTs.

PI_NAMEs: HILL, CONNOR MACKENZIE (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Address;Affect;American;Antibodies;ATAC-seq;Benign;Binding;Cell Line;Cell Nucleus;Cell Proliferation;Cells;Chimeric Proteins;ChIP-seq;Chromatin;Chromosome inversion;Cleavage Under Targets and Release Using Nuclease;Complex;CRISPR/Cas technology;cytokine;Data;Data Correlations;Data Set;Development;Diagnostic;differential expression;Distal;Enhancers;EP300 gene;Fibroblasts;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Fusion;Gene set enrichment analysis;Genes;genetic corepressor;Genetic Transcription;Genomics;Growth;Histones;HL-60 Cells;HL60;Individual;inducible gene expression;Lung;Malignant - descriptor;Malignant Neoplasms;Measurement;Measures;Mesenchymal;Mesenchymal Cell Neoplasm;Micro Array Data;Modeling;Molecular;Multiprotein Complexes;Mutation;novel diagnostics;novel therapeutics;Nuclear;Oncogene Deregulation;Oncogenes;Oncogenic;Pathogenesis;Play;Positioning Attribute;Process;programs;Proliferating;Proteins;rare cancer;recruit;Recurrence;Repression;Resources;response;RNA;RNA analysis;RNA Polymerase II;Role;Solitary Fibrous Tumor;Stains;STAT6 gene;STAT6 Transcription Factor;System;Testing;therapeutic target;Time;Transactivation;Transcription Coactivator;transcription factor;transcriptome sequencing;tumor;Tumor Suppressor Genes;tumorigenesis;Work

PROJECT_TITLE: The molecular function of the oncogenic NAB2-STAT6 fusion protein


NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Inflammatory Bowel Disease

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: RELEVANCE (See instructions): The studies proposed will be highly significant in several fundamental ways: (a) they will address the  specificity of CNBP for IL12 family expression; (b) they will advance understanding of how CNBP exerts  cell type specific control on TH1 and TH17 immunity; (c) they will provide increased understanding of how  long-non-coding RNAs impact immune gene expression and the inflammatory response in cells and  animals.

PI_NAMEs: FITZGERALD, KATHERINE A. (contact)

PROGRAM_OFFICER_NAME: LEITNER, WOLFGANG W

PROJECT_TERMS: Animals;Award;Binding;Binding Proteins;Binding Sites;Biochemical;Biology;Breeding;Candida albicans;Cell Lineage;Cell Nucleus;cell type;Cells;ChIP-seq;Complement;Complex;Confocal Microscopy;CRISPR/Cas technology;Cytosol;dextran sulfate sodium induced colitis;DNA;DNA Binding;EMSA;Epitopes;experimental study;Family;Funding;Gene Expression;Gene Expression Regulation;Gene Family;Genes;Genetic Transcription;Genome;Goals;Grant;Human;Immune;Immune response;Immunity;in vivo;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Innate Immune Response;insight;Instruction;Interleukin-12;interleukin-23;Interphase Cell;ITGAX gene;Knockout Mice;Link;LoxP-flanked allele;Luciferases;Macrophage;Maps;Modeling;Molecular;Mus;mutant;Mutation;Myeloid Cells;Natural Immunity;novel;Nuclear;Nuclear Translocation;nucleic acid binding protein;Nucleic Acid Regulatory Sequences;Phase;Process;promoter;Proteins;Regulation;Reporter Genes;response;Role;Site;Specificity;Testing;Toxoplasma gondii;Untranslated RNA;Work

PROJECT_TITLE: Gene Regulation in Innate Immunity

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: PROVIDENCE PORTLAND MEDICAL CENTER

ORG_STATE: OR

PHR: Macrophage suppression of T cell responses in the tumor immune environment represents an important problem limiting cure of residual disease following radiation therapy. We use high quality preclinical models of radiation therapy and immunotherapy to understand the mechanisms of success and failure in myeloid suppression of the T cell control of tumors. This is combined with analysis of clinical samples to explore how a novel mechanistic interaction between immune cells determines immune mediated tumor control.

PI_NAMEs: GOUGH, MICHAEL JAMES (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Adjuvant;Anti-Inflammatory Agents;Apoptotic;Bioinformatics;Biological;Biological Assay;cancer cell;cancer type;Cell Maturation;Cells;Cessation of life;checkpoint therapy;chemotherapy;Chemotherapy and/or radiation;Clinical;Collection;Cross Presentation;Cytotoxic Chemotherapy;Data;Data Set;Dendritic Cells;Dose;Environment;environmental enrichment for laboratory animals;Exposure to;extranuclear DNA;Failure;Fractionation;Gene Expression Profile;Genes;Genetic Transcription;Heat shock proteins;HMGB1 gene;Immune;immune function;Immunity;immunogenic;Immunologic Adjuvants;Immunotherapy;improved;improved outcome;In Vitro;in vivo;Inflammatory;Interferons;Intervention;IRF3 gene;Knock-out;Link;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Myelogenous;Myeloid Cells;Necrosis;NF-kappa B;novel;Outcome;Pancreas;pancreatic cancer model;Pathologic;Pathology;patient population;patient response;patient subsets;Patient-Focused Outcomes;Patients;Pre-Clinical Model;prevent;Process;Radiation therapy;Regulation;Research Design;Residual Neoplasm;response;RNA;Sampling;sensor;Signal Transduction;Stimulator of Interferon Genes;success;T cell response;T-Lymphocyte;Testing;Therapeutic;Toll-like receptors;Transcriptional Regulation;Treatment Failure;tumor;Tumor Biology;Tumor Immunity;Tumor-associated macrophages

PROJECT_TITLE: Rewiring the myeloid cell response to adjuvants to improve tumor control

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative The purpose of our studies is to identify novel therapeutic vulnerabilities for a common type of aggressive lymphoma (diffuse large B-cell lymphoma) by understanding the role of lymphoma associated fibroblasts that are part of the tumor microenvironment. We will determine the mechanisms that fibroblasts utilize to sustain lymphoma cell grow and to decrease the lymphoma immune response. If successful, these studies will launch the development of specific and likely low-toxicity treatments that could benefit patients with incurable lymphomas.

PI_NAMEs: CERCHIETTI, LEANDRO C (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Apoptosis;B-Cell Lymphomas;Biochemical;Biological;Biology;biomechanical test;Biomechanics;cancer cell;cancer infiltrating T cells;Cells;Coculture Techniques;Data;Dependence;Development;Engraftment;Event;Extracellular Matrix;Fibroblasts;Generations;Genetic;Genetic Transcription;Genotype;Goals;Growth;heat-shock factor 1;human disease;Immune;Immune Evasion;Immune response;Immunity;Immuno-Chemotherapy;Immunosuppression;implantation;In Vitro;insight;Knockout Mice;large cell Diffuse non-Hodgkin's lymphoma;Lead;Lymphoma;Lymphoma cell;Lymphomagenesis;Malignant Neoplasms;mechanical properties;Mediating;Mesenchymal;Molecular;molecular subtypes;mouse model;Mus;Mutation;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Pathogenesis;Pathway interactions;Patients;permissiveness;Phenotype;Population;pre-clinical;Privatization;Process;prognostic value;programs;Proliferating;Regulatory T-Lymphocyte;Research;Role;Solid Neoplasm;Spontaneous Remission;Stromal Neoplasm;supportive environment;Testing;Therapeutic;trait;transcription factor;transcriptomics;Translating;Treatment-related toxicity;tumor;tumor eradication;tumor growth;tumor microenvironment;tumorigenesis

PROJECT_TITLE: Role of the stromal microenvironment in B-cell lymphoma progression and immune escape


ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: PROJECT NARRATIVE Ribonucleic acids (RNAs) serve as a bridge between the DNA code and proteins. Identifying what RNAs are enzymatically modified will enable new research addressing issues such as cardiovascular disease and cancer that are affected by abnormalities in modification patterns.

PI_NAMEs: LIMBACH, PATRICK A (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;Affect;Anticodon;Bar Codes;Biological;Biological Assay;Biological Process;Cardiovascular Diseases;Catalogs;cell growth regulation;Cell Line;cell type;Cells;Cellular Stress;Censuses;Code;Comparative Study;Complex;Complex Mixtures;data acquisition;density;Development;Digestion;Discipline;Disease;Disease Progression;DNA;Effectiveness;Exclusion;Fibroblasts;Fractionation;Funding;Gene Expression;Generations;Goals;high throughput technology;Human;human disease;Human Pathology;human tissue;Individual;innovation;insight;Investigation;Knowledge;Laboratories;Life;Liquid Chromatography;Location;Maintenance;Malignant Neoplasms;Maps;Mass Spectrum Analysis;melanocyte;Melanoma;Metabolic;Metastatic Melanoma;Methods;Modification;next generation sequencing;novel;Nucleosides;Nucleotides;Oligonucleotides;Pattern;Physiological;Population;Positioning Attribute;posttranscriptional;Preparation;Process;Progress Reports;Protein Biosynthesis;Proteins;proteostasis;Regulation;Research;Research Personnel;Resolution;Ribonucleosides;RNA;Role;Sampling;stem;success;tandem mass spectrometry;Techniques;Time;Tissues;Transcript;Transfer RNA;Variant;Work

PROJECT_TITLE: Mass Spectrometry of Modified RNAs

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]