NIH_SPENDING_CATS: Immunization;Microbiome

ORG_CITY: SYRACUSE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Project Narrative: The microbiome is composed of complex communities of bacteria that dynamically interact the each other and with their host. Secretion of IgA antibodies helps maintain intestinal homeostasis and promotes healthy microbial communities that are associated with positive health outcomes in humans. The goal of this proposal is to define the bacterial properties and gene-level mechanisms that promote IgA production throughout the body.

PI_NAMEs: WILMORE, JOEL R (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Affect;Antibodies;Antibody Response;Bacteria;Bone Marrow;commensal bacteria;Communities;Complex;Diabetes Mellitus;Disease;Equilibrium;Frequencies;Genes;Goals;Health;Human;Humoral Immunities;Hypersensitivity;Immunoglobulin A;Individual;Inflammatory Bowel Diseases;Integration Host Factors;intestinal homeostasis;Lamina Propria;Link;microbial community;microbiome;Modeling;Mucous Membrane;novel therapeutics;Obesity;Outcome;Plasma Cells;Production;programs;Property;Research;response;Sepsis;Serum;Site;Specificity;System;vaccine delivery;Vision

PROJECT_TITLE: Mechanisms of commensal bacteria induced humoral immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cachexia;Cancer;Lung;Lung Cancer

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Cancer cachexia (CC) is a wasting syndrome characterized by anorexia, weight loss, and muscle and fat loss, which can be caused by cancer itself and often worsened by chemotherapy; current interventions for preventing or treating CC are suboptimal. 5’-adenosine monophosphate-activated protein kinase (AMPK), an intracellular energy sensor, plays a central role in skeletal muscle physiology by regulating mitochondria and it also shows anti-inflammatory effects; however, the function of AMPK in CC and its potential therapeutic role in preventing muscle wasting and weakness is unknown. The proposed study will characterize the role of AMPK in cancer- and chemotherapy-induced muscle wasting and dysfunction in vivo and in vitro and evaluate the potential for promoting AMPK activation as a therapeutic target for these conditions.

PI_NAMEs: KERR, HAIMING LIU (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Adenosine Monophosphate;Adult;Affect;Agonist;Animals;Anorexia;Antiinflammatory Effect;Attenuated;Autophagocytosis;Biogenesis;Body Composition;Body Weight;Body Weight decreased;Cachexia;Cancer Cachexia;Cancer Etiology;Cancer Model;Cancer Patient;cancer therapy;cancer type;cell type;chemotherapeutic agent;chemotherapy;Cisplatin;Coculture Techniques;Colon Carcinoma;Complex;cytokine;Desire for food;Development;Drug usage;Eating;experimental study;Fasting;Fatigue;Fatty acid glycerol esters;FDA approved;Fiber;Functional disorder;Genetic;Goals;grasp;Head and Neck Cancer;Hydrogen Peroxide;Impairment;Implant;improved;In Vitro;in vivo;Inflammation;Inflammatory;interest;Interleukin-1 beta;Interleukin-6;Intervention;Investigation;Kinetics;Lewis Lung Carcinoma;Lewis lung carcinoma cell;life span;Longevity;Lung;Magnetic Resonance Imaging;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of testis;Malignant neoplasm of urinary bladder;Malignant Neoplasms;MAP Kinase Gene;Measurement;Measures;Mediating;Medical Care Costs;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Modification;Molecular;Mus;Muscle;Muscle Fibers;muscle form;Muscle function;muscle physiology;Muscle Weakness;Muscular Atrophy;Muscular Dystrophies;Myopathy;Neuromuscular Junction;NF-kappa B;novel;novel therapeutics;Outcome;Oxidative Stress;Palpable;Pathologic;Pathway interactions;Patients;pharmacologic;Physical Function;Platinum;Play;prevent;Production;Protein Kinase;protein kinase inhibitor;protein kinase modulator;Quality of life;Reactive Oxygen Species;Regulation;Relaxation;Reporting;Research;Research Design;Research Personnel;Respiration;response;Ribonucleotides;Rodent Model;Role;sensor;side effect;Signal Pathway;Signal Transduction;SIRT1 gene;Skeletal Muscle;Small Interfering RNA;Spectrum Analysis;Stains;Syndrome;Testing;Therapeutic;therapeutic target;TNF gene;Transgenic Mice;Treadmill Tests;tumor;Wasting Syndrome;Wild Type Mouse

PROJECT_TITLE: The Role of AMPK in Regulating Muscle Mass and Function in Cancer Cachexia

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: TUCSON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative/ Public Health Relevance Inflammatory bowel diseases (IBD) are complex, multifactorial disorders characterized by impaired host- microbiome interactions that lead to chronic and relapsing intestinal inflammation with incompletely understood etiology For the first time, we demonstrate that poly-ADP-ribosylation (PARylation), a post-translational protein modification known to profoundly affect cellular functions in other systems, plays active role in the gut epithelial cell biology, host-microbiome interactions, and mucosal inflammatory responses. We seek to determine the interplay between commensal microbiota and mucosal PARylation, work that may lead to novel approaches to IBD care.

PI_NAMEs: GHISHAN, FAYEZ KHALAF;KIELA, PAWEL R (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Adenosine Diphosphate Ribose;ADP ribosylation;Affect;Amino Acids;anti aging;bacterial community;Biology;candidate identification;Caring;Cell Compartmentation;Cell Physiology;Cellular biology;Chronic;Clinical;Coenzyme A;cofactor;Colitis;Colon;Colonic inflammation;commensal bacteria;commensal microbes;comparative;Complex;Data;design;Disease;Disease Progression;DNA Repair Enzymes;efficacy evaluation;Energy Metabolism;Epithelial Cells;Epithelium;Etiology;FDA approved;fecal transplantation;gastrointestinal;gastrointestinal epithelium;Genetic Transcription;Germ-Free;gut inflammation;gut microbiota;Gut Mucosa;Homeostasis;host microbiome;Human;Hyperactivity;Immune response;Immune system;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;inhibitor;Injury;Knock-out;large bowel Crohn's disease;Maintenance;Marketing;Mediating;Metabolic;Microbe;microbial community;microbial composition;microbiome alteration;microbiome composition;microbiota;Mind;Modeling;Mucositis;Mucous Membrane;murine colitis;Mus;nicotinamide-beta-riboside;novel;novel strategies;Onset of illness;oral supplementation;Outcome;Pathogenesis;Patients;pharmacologic;Play;Poly(ADP-ribose) Polymerases;Polymerase;Post-Translational Protein Processing;Predisposition;protein function;Proteins;public health relevance;Recovery;Regulatory T-Lymphocyte;Relapse;Research;Risk;Role;Sirtuins;Supplementation;System;targeted treatment;Testing;Time;Work

PROJECT_TITLE: PARP1 and PARylation as novel effectors of gut inflammation

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Cost Effectiveness Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: Newark

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Tuberculosis is a leading cause of death due to an infectious disease. Most cases occur in low and middle income countries where access to diagnostics such as culture may be limited to a few reference centers. FEND for TB will identify and assess inexpensive tests that are available at the point of care where the patients first are evaluated; once validated, these tests will enable more rapid identification and treatment of TB.

PI_NAMEs: ALLAND, DAVID ;DORMAN, SUSAN E;ELLNER, JERROLD J. (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Acceleration;Address;Adult;Age;Algorithms;Bacille Calmette-Guerin vaccination;Biological Assay;Caring;Cause of Death;Characteristics;Child;Childhood;China;clinical diagnostics;Clinical Research;clinical research site;Clinical Sciences;Collaborations;Communicable Diseases;comorbidity;cost;Cost Analysis;cost effectiveness;Costs and Benefits;Country;Data;design;Detection;Diabetes Mellitus;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic algorithm;diagnostic strategy;diagnostic technologies;Diagnostic tests;Diagnostics Research;Drug resistance;Drug resistance in tuberculosis;economic evaluation;Economics;Enrollment;Ensure;Evaluation;experience;Exposure to;Feedback;field study;Foundations;Funding;Genus Mycobacterium;Good Clinical Practice;good laboratory practice;Health;Health Benefit;Health system;HIV Infections;improved;India;innovation;interest;Laboratories;Leadership;low and middle-income countries;Lung;Malnutrition;mathematical model;Modeling;Multidrug-Resistant Tuberculosis;Mycobacterium tuberculosis;novel;novel diagnostics;Outcome;participant enrollment;Patients;Performance;Peru;Pharmaceutical Preparations;point of care;Policies;Population;Predisposition;programs;prospective;Pulmonary Tuberculosis;Readiness;recruit;Reference Standards;Research;Research Design;Research Personnel;Resistance;response;sample collection;Site;South Africa;Specific qualifier value;Specimen;Sputum;statistics;Technology;Testing;transmission process;Triage;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;tuberculosis treatment;Uganda;United States National Institutes of Health;Work

PROJECT_TITLE: FEND for TB


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Services;Immunization;Infectious Diseases;Influenza;Kidney Disease;Pneumonia and Influenza;Prevention;Primary Health Care;Vaccine Related

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE/RELEVANCE Individuals with CKD are most in need of vaccine protection, yet their uptake of influenza vaccination is suboptimal. Through this project, the candidate will establish effective strategies to improve the uptake of influenza vaccination among individuals with CKD, and obtain necessary skill sets and experiences to make a successful transition to an independent researcher.

PI_NAMEs: ISHIGAMI, JUNICHI  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Address;Adherence;Adoption;Adult;Affect;aged;Agreement;Anemia;Awareness;Behavior;Behavioral;Belief;budget impact;Cardiovascular Diseases;career;Caring;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;Chronic Kidney Failure;Chronic Kidney Insufficiency;Clinic;Clinical;cohort;Communicable Diseases;comorbidity;comparative cost effectiveness;Consolidated Framework for Implementation Research;cost effective;cost effectiveness;cost-effectiveness evaluation;COVID-19;Data;Decision Making;design;Development;disorder prevention;Doctor of Philosophy;Education;Epidemiology;ethnic diversity;evidence base;experience;Exposure to;feasibility testing;Five-Year Plans;Foundations;Funding;Funding Mechanisms;Goals;Health Care Costs;health related quality of life;Healthy People 2020;high risk;high risk population;Hospitalization;human old age (65+);Immunization;Immunization Programs;implementation cost;implementation research;implementation strategy;improved;incremental cost-effectiveness;Individual;Infectious Disease Epidemiology;Influenza;Influenza vaccination;influenza virus vaccine;Information Systems;Intervention;Kidney;Knowledge;Longitudinal cohort;Mentored Research Scientist Development Award;Mentors;Mentorship;Modeling;mortality risk;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;Patients;Perception;Persons;Physicians;Pneumonia;Population;Program Development;programs;Provider;provider-level barriers;Public Health;Public Health Schools;Questionnaires;Recommendation;Reporting;Research;Research Personnel;Research Proposals;Resources;skills;Surveys;Testing;theories;Trust;United States;United States National Institutes of Health;Universities;uptake;Vaccination;vaccine acceptance;vaccine delivery;vaccine safety;Vaccines

PROJECT_TITLE: Implementation research to improve the uptake of influenza vaccination in CKD


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Contraception/Reproduction;Dementia;Estrogen;Genetics;Human Genome;Menopause;Neurodegenerative;Neurosciences;Women's Health Research

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: NARRATIVE Women represent two-thirds of Alzheimer's disease (AD) cases in the US and the drivers of this health inequality remain inexplicable. What is clear, is that both menopause and DNA damage affect gene expression within pathways that influence tissue aging and metabolism, and hence likely AD. The impact of menopause on DNA damage and epigenetic responses has not been scrutinized in the context of AD. We will identify menopause- related impacts on AD-related networks, identifying druggable pathways or targets that may lead to sex-specific strategies for treating AD and identify potential biomarkers.

PI_NAMEs: VOLMAR, CLAUDE-HENRY ;WAHLESTEDT, CLAES ROBERT (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: 3xTg-AD mouse;4-vinylcyclohexene diepoxide;Acceleration;AD transgenic mice;Affect;Age;aged;Aging;aging biomarker;aging mechanism;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's Disease Pathway;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer’s disease biomarker;Astrocytes;behavior test;Behavioral;biobank;Biological;Biological Markers;Blood;Brain;brain cell;Brain region;case control;Chromatin;chromatin remodeling;Cleavage Under Targets and Release Using Nuclease;Clinical Research;cognitive control;cohort;Coupled;Data;Defect;Dementia;design;Detection;digital;Disease;DNA analysis;DNA Damage;DNA Methylation;DNA Repair;DNA Single Strand Break;druggable target;Energy Metabolism;epigenetic drug;Epigenetic Process;Estrogens;Exhibits;Female;Florida;Functional disorder;Future;Gene Expression;Genes;Genetic Markers;Genetic Transcription;Genome;glucose metabolism;glucose tolerance;Gonadal Steroid Hormones;health inequalities;High Prevalence;Histone Acetylation;histone modification;Homeostasis;Hormonal;Human;Impaired cognition;Individual;Inflammation;Inflammatory Response;Injections;Insulin Resistance;Learning;Link;London;Lymphocyte;male;Maps;Mediating;Memory;Memory impairment;Memory Loss;men;Menopause;Metabolic;Metabolism;Methods;Microglia;mild cognitive impairment;mind/body;Modeling;Modification;Molecular;mouse model;Mus;Mutation;nano-string;Nerve Degeneration;network models;Neurons;neuropathology;novel;novel marker;Nucleotides;ovarian failure;Ovariectomy;Pathologic;Pathway Analysis;Pathway interactions;Perimenopause;Peripheral;Pharmaceutical Preparations;Play;Postmenopause;potential biomarker;presenilin-1;prevent;Process;Progesterone;Proteins;Public Domains;Quantitative Reverse Transcriptase PCR;repair enzyme;Reporting;reproductive;Research;Resolution;response;Role;sex;Sex Differences;sexual dimorphism;Single Strand Break Repair;spatiotemporal;Study models;Testing;Therapeutic;timeline;Tissues;transcriptome;transcriptomics;Wild Type Mouse;Woman;women patients;Work

PROJECT_TITLE: The Role of Menopause-Driven DNA Damage and Epigenetic Dysregulation in Alzheimer s Disease


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: The goal of this proposal is to identify the contributions of social and dietary factors to kidney stone risk in racially and ethnically diverse populations. If successful, the proposed research will provide insight into the reasons for rising kidney stone prevalence in racial and ethnic minority groups and help develop more effective strategies for secondary prevention. The proposed research corresponds to NIDDK’s scientific goals to identify and characterize factors that affect human health in diverse populations; and to analyze the links between biology, behavior, and the environment, including social determinants of health and structural factors, that contribute to disease heterogeneity and health disparities.

PI_NAMEs: CRIVELLI, JOSEPH JAMES (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: Adopted;Adult;Affect;Behavior;Biology;Biometry;Black Populations;Black race;Body mass index;Calcium Oxalate;career development;Chronic;Chronic Disease;clinical center;Clinical Investigator;Clinical Sciences;Clinical Trials;cohort;Cohort Analysis;Cohort Studies;Consumption;Coronary Artery Risk Development in Young Adults Study;DASH diet;Data;data harmonization;Development;Diabetes Mellitus;Diet;Diet Modification;dietary;Dietary Assessment;Dietary Factors;Dietary Practices;Dietetics;Disadvantaged;Disease;disease heterogeneity;disorder prevention;disorder risk;Disparity population;Economics;Education;efficacy testing;Enrollment;Environment;Environmental Risk Factor;Epidemiology;ethnic diversity;ethnic minority;ethnic minority population;Ethnic Origin;Event;experience;Family Study;follow-up;Foundations;Funding;Future;Goals;good diet;Grant;Health;Health Care Costs;health disparity;health inequalities;healthy lifestyle;Heart;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;Hour;Human;Hypertension;improved;Incidence;Income;Individual;insight;Institution;Jackson Heart Study;Kidney Calculi;Life Style;Link;Low Prevalence;Measures;Medical;Mentored Patient-Oriented Research Career Development Award;Mentors;modifiable risk;Modification;Multi-Ethnic Study of Atherosclerosis;National Institute of Diabetes and Digestive and Kidney Diseases;Not Hispanic or Latino;nutrition;Nutritional Study;Observational Study;Outcome;Participant;patient oriented;Patients;Pattern;Population;Population Heterogeneity;Prevalence;prevent;Prevention;Preventive care;primary outcome;Productivity;prospective;Public Health;Quality of life;Race;racial diversity;racial minority;racial minority population;Randomized;Recording of previous events;Reporting;Research;Research Personnel;Resources;Risk;Risk Factors;Science;Secondary Prevention;sex;social;social factors;social health determinants;social influence;Standardization;structural determinants;systemic barrier;Testing;Time;Training;Training Programs;Translational Research;Urinary Calculi;Urine;western diet;Work

PROJECT_TITLE: Social and Dietary Determinants of Kidney Stone Risk

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Autoimmune Disease;Cannabinoid Research;Endocannabinoid System Research;Lupus;Therapeutic Cannabinoid Research

ORG_CITY: GREENVILLE

ORG_NAME: ZYLO THERAPEUTICS, INC.

ORG_STATE: SC

PHR: Narrative Approximately 500,000 people in the U.S. suffer from cutaneous lupus lesions (CLE),with a significant impact on quality of life.4 Yet, there is no cure, the treatment options are limited, and no new drug has been FDA-approved for over 50 years.84 There is compelling preliminary data to support anandamide (AEA) as a promising drug candidate for CLE including in vitro work using tissue from human CLE patients and two in vivo murine studies demonstrating that AEA loaded into a novel topical silica-derived particle delivery system (AEA-ZP) significantly reduces the size and severity of lupus lesions as compared to controls, including unencapsulated AEA. The goal of this Phase I proposal is: (1) confirm efficacy of AEA-ZP in a newly developed murine model of lupus and assess preliminary toxicity; (2) identify biomarker profiles that may predict response to treatment with AEA-ZP; and (3) produce AEA-ZP prototypes with higher load factors and conduct stability testing.

PI_NAMEs: DRAGANSKI, ANDREW R (contact);WERTH, VICTORIA P

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: Acceleration;Adaptive Immune System;Affect;Age;Alopecia;anandamide;Anxiety;Apoptosis;Autoimmune Responses;Binding;Biological Availability;biomarker identification;Blood;cannabinoid receptor;Cells;Cellular Stress;chemokine;child bearing;Cicatrix;clinical development;CNR2 gene;Coconut Oil;Color;comorbidity;comparison control;Complex;Cutaneous;cytokine;Data;Dermatitis;Dermatology;Development;Dose;drug candidate;efficacy evaluation;efficacy study;Encapsulated;Endocannabinoids;Environmental Risk Factor;Face;fatty acid amide hydrolase;fatty acid metabolism;FDA approved;Female;Formulation;Foundations;Genetic;Goals;Histologic;Human;human tissue;immune function;Immune response;immunoregulation;In Vitro;in vivo;Inflammation;Inflammatory;Innate Immune Response;intense pain;Interferons;Knockout Mice;Lesion;Letters;Leukocytes;Lupus;lupus cutaneous;Lupus Erythematosus;Lymphocyte;Macrophage;Maintenance;Manuscripts;Mediator;Mental Depression;Methods;mouse model;Mus;novel;novel therapeutics;Nuclear;Organ;Pain;particle;Pathogenesis;Pathway interactions;patient population;Patients;Penetration;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Phase;pre-clinical;predicting response;Preparation;prototype;Pruritus;Quality of life;receptor expression;recruit;safety study;sensory input;Series;Severities;Silicon Dioxide;Skin;skin barrier;skin lesion;Skin Tissue;specific biomarkers;stability testing;Stratum corneum;Subgroup;System;Therapeutic;Tissues;Topical application;Toxic effect;treatment response;Ultraviolet B Radiation;Up-Regulation;Work

PROJECT_TITLE: Development of an endocannabinoid microparticle formulation for the topical treatment of cutaneous manifestations of lupus erythematosus.


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

ORG_CITY: HOUSTON

ORG_NAME: TEXAS HEART INSTITUTE

ORG_STATE: TX

PHR: Recent definitive clinical trials like CANTOS, LoDoCo2, and COLCOT, have proven the inflammatory hypothesis underlying atherosclerotic disease. They have also shown that targeting residual inflammatory risk, even in those patients currently on best standards of care, can have significant benefits in clinical outcomes. We are proposing a novel, first-in- class approach to target the early signaling events that lead to systemic inflammation in atherosclerosis, as a means to address residual inflammatory risk.

PI_NAMEs: BIEDIGER, RONALD J;WOODSIDE, DARREN G (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Acute;Address;adhesion receptor;Adhesions;analog;antagonist;Anti-Inflammatory Agents;arm;Arterial Fatty Streak;assay development;Atherosclerosis;atherosclerotic plaque rupture;atherothrombosis;Award;B-Cell Antigen Receptor;Biological Assay;Biological Products;Cardiac;Cardiovascular Diseases;cardiovascular disorder prevention;Cardiovascular system;Caring;Cause of Death;CCL2 gene;Cell surface;Cells;Cholesterol;Clinical;Clinical Trials;Colchicine;cytokine;Cytoplasmic Tail;design;Development;Disclosure;Disease;Dose;drug development;drug discovery;Drug Kinetics;Event;Fc Receptor;Funding Opportunities;Future;Genetic Transcription;Goals;Grant;Heart Diseases;Immune response;Immune system;improved;In Vitro;in vivo;Inflammation;Inflammatory;Integrin beta Chains;Integrin Inhibition;Integrins;interest;Interleukin-1 beta;invention;Lead;lead series;Legal patent;Leukocyte Trafficking;Leukocytes;Link;Lipids;literature survey;Macrophage;Mediating;Modeling;molecular dynamics;molecular modeling;monocyte;mortality;mouse model;Mus;Myocardial Ischemia;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;Outcome Study;Pathway interactions;patient population;Patients;Permeability;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase;Phosphotransferases;Play;prevent;Production;Program Development;programs;Property;Protein Tyrosine Kinase;Publishing;Receptor Signaling;Regulation;Residual state;response;Risk;Role;Route;Safety;screening;Secondary Prevention;Seminal;Signal Transduction;Site;small molecule;Source;Specificity;Stroke;Structure;Structure-Activity Relationship;SYK gene;systemic inflammatory response;Testing;Thrombosis;timeline;TNF gene;Toxic effect;Toxicity Tests;transmission process;United States;Up-Regulation;Validation;vascular inflammation;virtual;Work

PROJECT_TITLE: Targeting Integrin Signaling in Atherosclerosis


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: WASHINGTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Relevance As a result of population aging, many lower-income countries such as Nepal face a rapidly growing burden of dementia. This proposal represents a collaboration between the Institute for Social and Environmental Research in Nepal and the University of Michigan to develop a program of research capacity building and a population-based study to investigate the scope and primary determinants of dementia in Nepal. Findings from this program are expected to have substantial relevance for a better understanding of dementia risks and associated chronic health conditions in Nepal and other lower-income countries around the world.

PI_NAMEs: GHIMIRE, DIRGHA J;MENDES DE LEON, CARLOS F. (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Address;Adult;Affect;Age;age related;age related chronic disease;aged;Aging;aging population;aging related;Alzheimer's disease related dementia;Alzheimer's disease risk;caregiving;Chronic;Clinical;cognitive testing;cohort;Cohort Studies;Collaborations;complex data;Conflict (Psychology);Country;Data;Data Collection;Dementia;dementia burden;dementia risk;design;Development;disability;Economic Factors;Educational workshop;Eligibility Determination;Enrollment;Environment;experience;Exposure to;Face;Family;Family Study;follow-up;Foundations;Future;General Population;Health;Household;Impaired cognition;Incidence;Income;Infrastructure;International;Interview;Investigation;Labor Migrations;late life;Long-Term Effects;longitudinal analysis;Longitudinal cohort study;Longitudinal Studies;low and middle-income countries;low income country;Methods;Michigan;Modeling;Nepal;Nerve Degeneration;novel;older adult;Outcome;Participant;Policies;Politics;Population;population based;Population Research;Population Study;population survey;Prevalence;Prevention;Prevention strategy;Program Sustainability;programs;Research;Research Activity;Research Personnel;Resources;Risk;Risk Factors;Role;Sampling;Series;social;social factors;social relationships;Statistical Data Interpretation;Statistical Methods;Surveys;Testing;Training;Universities;virtual;Work

PROJECT_TITLE: International Labor Migration, Armed Conflict and Dementia Risk in Nepal: A Population Study


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Patient Safety;Pediatric;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Our proposed prospective research, focusing on examining the effectiveness of both a telehealth platform and an innovative treatment approach for parents and primary caregivers as well as frontline healthcare providers who are currently experiencing unprecedented levels of perceived stress during the COVID-19 pandemic, is expected to provide support to these highly vulnerable groups based in the Bronx who normally encounter significant barriers to basic care. If successful, the study has the potential to offset several of the negative social determinants of health typically encountered by members of these vulnerable communities. As such, the clinical implications of our proposed research are potentially profound.

PI_NAMEs: ALPERT, JONATHAN EDWARD (contact);GABBAY, VILMA

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Address;Adherence;Age;Anxiety;anxiety symptoms;arm;Autoimmune;barrier to care;Caregivers;Caring;Case Manager;Cellular Phone;Cessation of life;Child;Child Mental Health;Clinic;Clinical;clinical infrastructure;cohort;community intervention;Community Psychiatry;comorbidity;Complex;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;dashboard;Data;design;digital platform;Disadvantaged;Distress;effectiveness evaluation;efficacy evaluation;Emotional;Enrollment;ethnic minority population;evidence base;experience;Face;Family;Financial Hardship;follow-up;Food;Health;health care availability;health disparity populations;Health Insurance Portability and Accountability Act;Health Personnel;Health Resources;Health system;Housing;improved;Infrastructure;innovation;Institutional Review Boards;Intervention;Machine Learning;maltreatment;Measures;Mediating;Medical;Medical center;member;mentalization;Minority;Modeling;mood symptom;Moods;Mothers;multimodality;New York City;online care;Outcome;Outcome Measure;outcome prediction;pandemic disease;pandemic stress;Parenting Education;parenting intervention;Parents;Participant;Patients;Pattern;perceived stress;Pilot Projects;Population;Poverty;primary caregiver;primary outcome;Procedures;programs;prospective;psychologic;psychological distress;Psychological Stress;Psychopathology;racial minority population;Randomized, Controlled Trials;relative effectiveness;Research;response;Risk;Sample Size;School-Age Population;Schools;Security;smartphone application;Social Distance;social health determinants;Stress;Substance Use Disorder;substance use treatment;Surveys;Technology;telehealth;Testing;Therapeutic;Trauma;Underserved Population;United States National Institutes of Health;vulnerable community;Vulnerable Populations;Work

PROJECT_TITLE: A Multimodal Parent-focused Intervention for Vulnerable Populations in the Bronx

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-W(56)R]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Infectious Diseases;Malaria;Neurosciences;Rare Diseases;Vector-Borne Diseases

PHR: NARRATIVE This project will study the role of pipecolic acid in the etiology of cerebral malaria coma, a condition that contributes to worldwide morbidity and mortality and secondly, determine how it is produced by the malaria parasite. This research will contribute to fundamental knowledge underlying the loss of consciousness associated with cerebral malaria and potentially identify novel malaria metabolic pathways that could serve as a target of future antimalarial development.

PI_NAMEs: DAILY, JOHANNA PATRICIA (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Affect;African;Amino Acids;Animal Model;Animals;Anti-malarials;biological adaptation to stress;Biological Markers;biological systems;Biology;Blood;blood-brain barrier crossing;Brain;Central Nervous System;Cerebral Malaria;Cerebrospinal Fluid;Child;Childhood;Clinical;Cohort Studies;Collaborations;Coma;Complication;Conscious;Development;Disease;Encephalopathies;enzyme pathway;Erythrocytes;Etiology;Extracellular Matrix;Future;gamma-Aminobutyric Acid;Goals;Health;Human;hypnotic;improved;In Vitro;in vivo;Individual;Infection;Intervention;Kidney Failure;knock-down;Knock-out;Knowledge;Lysine;Lysine Degradation Pathway;Malaria;Mammalian Cell;Measures;Metabolic;Metabolic Pathway;Metabolism;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Neurologic;Neurologic Effect;neuroregulation;Neurosciences;novel;Outcome;Oxidative Stress;Parasitemia;Parasites;Pathway interactions;Patients;Pipecolic Acids;Plasma;Plasmodium;Plasmodium falciparum;Plasmodium falciparum genome;Play;Production;Public Health;Rattus;Reactive Oxygen Species;receptor;Research;Rodent;Rodent Model;Role;saccharopine;Saccharopine Dehydrogenases;Survivors;System;Testing;Time;Unconscious State;Wakefulness

PROJECT_TITLE: Defining the mechanism of coma in cerebral malaria

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Clinical Research;Lung;Neurosciences

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE The severe acute respiratory syndrome and the long-term respiratory sequalae experienced by many coronavirus-19 patients have heightened the importance of breathing, bringing us closer to those suffering from respiratory diseases such as persistent dyspnea (constant breathing discomfort). When the primary treatment option (pulmonary rehabilitation) does not alleviate the symptoms of dyspnea, brain-targeted treatment alternatives resort to opioids and benzodiazepines which produce dependence, suppress ventilatory drive and contribute to hypercapnic respiratory failure. A better understanding of the cortical and subcortical mechanisms that modulate respiratory-related afferents to shape the subjective sensations of dyspnea will inform both, treatments that reduce dyspnea without reducing ventilatory drive and mechanisms underlying cortical control of respiration.

PI_NAMEs: HERRERO RUBIO, JOSE LUIS (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Affective;Air;alternative treatment;analog;Animals;Anterior;Area;Asphyxia;Asthma;Awareness;Benzodiazepines;Brain;Brain region;Brain Stem;Breathing;Cardiac;Caring;Chronic;Chronic Obstructive Pulmonary Disease;chronic pain;cingulate cortex;Clinical;Complex;Conscious;Coronavirus;Coupled;Coupling;COVID-19;COVID-19 pandemic;Dependence;Descriptor;design;Detection;Dimensions;Disease;Distress;Dyspnea;effective therapy;Electric Stimulation;Electrical Stimulation of the Brain;Electroencephalography;Electrophysiology (science);Epilepsy;Esthesia;Etiology;experience;experimental study;feature detection;Feeling;Foundations;Frequencies;Fright;functional magnetic resonance imaging/electroencephalography;Future;General Population;Heart Diseases;Human;Hypercapnic respiratory failure;Implanted Electrodes;improved;Interstitial Lung Diseases;Intervention;Link;Lung;Lung Diseases;machine learning method;mechanical load;Medical;meetings;Methods;Modeling;Monitor;neural;neuromuscular;Neuromuscular Diseases;neuronal circuitry;Neurons;Opioid;Pain;Palliative Care;Participant;Pathology;Patients;Perception;Persons;Pharmaceutical Preparations;Physiology;Population;Prevalence;pulmonary rehabilitation;Resolution;Resort;Respiration;respiratory;Respiratory Disease;Respiratory Mechanics;Respiratory physiology;Respiratory Signs and Symptoms;Rodent;scaffold;Sensory;Severe Acute Respiratory Syndrome;Shapes;Signal Transduction;Site;Sleep Stages;Source;Structure;Symptoms;Syndrome;targeted treatment;Therapeutic Intervention;Time;tool;Visual;Water;Work;Work of Breathing

PROJECT_TITLE: Characterizing the Sensory and Affective Neural Components of Persistent Dyspnea

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Heart Disease;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: NARRATIVE Aging is a major risk factor for breast cancer and due to the aging of the U.S. population, the number of breast cancer survivors is expected to increase dramatically. Chemotherapy is a highly effective treatment for breast cancer but is associated with cardiovascular toxicity which may accelerate cardiovascular aging setting the stage for premature cardiovascular disease. The proposed research aims to build the evidence base for optimizing exercise prescription for cardiovascular disease prevention in breast cancer survivors by investigating two novel and innovative exercise regimens.

PI_NAMEs: CHRISTOU, DEMETRA  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;Acute;Address;Adherence;Aerobic Exercise;Age;age related;Age Years;Aging;Apoptosis;Attention;Biological Markers;Blood;brachial artery;breast cancer diagnosis;Breast Cancer Risk Factor;Breast Cancer survivor;Breast Cancer Treatment;Cardiac;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular system;Cessation of life;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;Clinical Trials;Compensation;Coronary Arteriosclerosis;Data;design;Development;Diagnosis;Echocardiography;effective therapy;Endothelial Cells;Endothelium;equilibration disorder;Equilibrium;evidence base;Exercise;exercise intervention;exercise prescription;exercise regimen;Exercise Therapy;exercise training;fall risk;Fatigue;Foundations;frailty;Functional disorder;Future;Harvest;Heart failure;heart function;human old age (65+);improved;Injury;innovation;insight;Interval training;Intervention;Limb structure;Lower Extremity;Malignant Breast Neoplasm;Mediating;minimally invasive;Muscle Weakness;Myocardial;Non-Insulin-Dependent Diabetes Mellitus;Nonmetastatic;novel;older adult;Participant;Pathway interactions;Patients;Peripheral Nervous System Diseases;Pilot Projects;Population;premature;prevent;Randomized;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;Recommendation;Research;Resolution;Risk;side effect;success;Supervision;Techniques;Time;Toxic effect;Training;treatment as usual;Treatment-Related Cancer;Ultrasonography;Upper Extremity;Woman;Women's trial;Work

PROJECT_TITLE: High Intensity Interval Training: Optimizing Exercise Therapy to Mitigate Cardiovascular Disease Risk Following Breast Cancer Chemotherapy

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Pulmonary infections like tuberculosis are more severe and occur more frequently in the elderly, so we propose studies in adults across an age continuum, with and without pulmonary tuberculosis. We anticipate that active tuberculosis may serve as a novel model of premature aging, and will serve for understanding the basis for the increase in lung oxidative stress and inflammation. Our findings will provide the foundation for the development of intervention(s) at defined younger ages to significantly mitigate aging-associated health decline.

PI_NAMEs: RESTREPO, BLANCA I (contact);TURNER, JOANNE

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Adult;Affect;Age;age acceleration;age effect;age group;age related;age related decline;Aging;aging process;aging related;Anti-Inflammatory Agents;Autoimmune Diseases;Biological;Biological Markers;Blood;Body System;Brain;Cells;chemokine;Clinical;cohort;Communities;Containment;Cross-Sectional Studies;cytokine;Defect;Diabetes Mellitus;Diagnosis;Elderly;Enrollment;Event;Exposure to;Failure;Foundations;functional decline;Functional disorder;Future;Genetic;Goals;Growth;Health;Health system;healthspan;High Prevalence;high risk;Hispanic;HIV;Homeostasis;Human;human old age (65+);Immune;immune function;Immune System Diseases;Immunologics;Impairment;in vivo;Individual;Infection;Inflammation;Intervention;Joints;Lead;Longitudinal Studies;Lung;Lung infections;Measures;Metabolic;Metabolic dysfunction;Metabolism;Mexico;Mitochondria;Modeling;Molecular;Monitor;monocyte;Morbidity - disease rate;mortality;Mus;Mycobacterium tuberculosis;Non-Insulin-Dependent Diabetes Mellitus;novel;older patient;Organ failure;Outcome;oxidation;Oxidative Stress;Oxidative Stress Induction;Oxidative Stress Pathway;Participant;pathogen;Pathway interactions;Patients;Persons;Phenotype;Plasma;Premature aging syndrome;prevent;Proteins;Pulmonary Tuberculosis;research clinical testing;Research Personnel;resilience;response;restoration;Role;Sampling;Site;Skeletal Muscle;Specimen;synergism;Testing;Texas;therapy development;Time;Tuberculosis;tuberculosis treatment;Waste Management

PROJECT_TITLE: Immune and metabolic dysfunction during aging in human cohorts


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: MEMPHIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Project Narrative Disruption of cerebellar development is associated with a broad spectrum of neurological disorders, ranging from ataxia to autism, and common pregnancy complications, such as preterm birth and intrauterine growth restriction. By identifying the mechanisms that regulate the development and scaling of neuronal populations in the cerebellum, our studies will provide a foundation for understanding cerebellar disorders and the development of regeneration therapies for the human cerebellum, which is frequently affected by both genetic and non-genetic factors.

PI_NAMEs: CHIZHIKOV, VIKTOR  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Affect;Ataxia;autism spectrum disorder;beta catenin;Brain;Brain Diseases;Candidate Disease Gene;Cell Fate Control;Cell Lineage;Cell secretion;cell type;Cells;Central Nervous System;Cerebellar Cortex;Cerebellar Diseases;Cerebellum;Cerebrospinal Fluid;cognitive function;conditional knockout;Cytoplasmic Granules;Cytoskeleton;Data;Data Set;Dependence;design;Development;developmental disease;Electroporation;Embryo;Equilibrium;Fetal Growth Retardation;Foundations;gain of function;Generations;Genes;Genetic;granule cell;Human;in utero;in vivo;inhibitor;insight;Interneurons;Intrinsic factor;Lip structure;loss of function;Malignant Neoplasms;Maps;Mediating;migration;Mitogens;Molecular;Motor;Mus;mutant;nerve stem cell;Nervous System Disorder;neural;neural circuit;Neurofibromatosis 2;Neurofibromin 2;Neuroglia;Neurons;non-genetic;novel;Output;overexpression;Pathogenesis;Pathway interactions;Phenotype;Phosphorylation Site;Population;Pregnancy Complications;Premature Birth;prevent;Process;Production;progenitor;Proliferating;prospective;Proteins;Purkinje Cells;regenerative therapy;Regulation;response;restraint;RNA analysis;Role;SHH gene;smoothened signaling pathway;Spinocerebellar Ataxias;stem cell expansion;stem cell fate;stem cell migration;stem cell proliferation;stem cells;System;Testing;Time;transcriptome sequencing;ubiquitin ligase;Ventricular;white matter

PROJECT_TITLE: Nf2-dependent regulation of neuronal scaling in the developing cerebellum

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ORG_CITY: WORCESTER

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Infections associated with metallic implants occur in 1-4% of primary total joint replacement and up to 30% of revisions. Current prophylactic local delivery of high-dose antibiotics is known for cytotoxicity and could risk the development of bacterial drug resistance while prolonged systemic antibiotic treatments are often ineffective in eradicating established infections. The proposed prophylactic metallic implant surface coating is designed to discourage bacterial colonization on implants while substantially improving the efficacy of a minimal safe dose of systemic antibiotic injection in rooting out implant associated infections. Page 5

PI_NAMEs: SONG, JIE  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Adsorption;Alkynes;Alloys;Antibiotic Prophylaxis;Antibiotic Therapy;Antibiotics;Azides;Bacteria;Bacterial Counts;Bacterial Drug Resistance;Binding;bioluminescence imaging;bone;Bone Marrow;Bone Matrix;Cell Proliferation;Chemicals;clinical translation;clinically relevant;combat;Complete Blood Count;copolymer;Copper;cortical bone;cycloaddition;cytotoxicity;Debridement;density;design;Development;Dose;efficacy evaluation;Electron Microscopy;Engineering;Environment;Femur;Frequencies;Histology;Implant;implant associated infection;implant coating;improved;In Vitro;in vivo;Infection;infection rate;Injections;Invaded;Length;manufacturing process;Measurement;metallicity;Metals;Methicillin;Methicillin Resistance;methicillin resistant Staphylococcus aureus;methicillin susceptible Staphylococcus aureus;Microbial Biofilms;Modeling;Modification;Molecular Weight;Monitor;Mus;Nature;Operative Surgical Procedures;Organ;Orthopedics;Osteogenesis;Outcome;Pathology;polymerization;Polymers;polymethacrylate;Predisposition;prevent;prophylactic;Prophylactic treatment;Proteins;Protocols documentation;Rattus;Recurrence;Regimen;Replacement Arthroplasty;Resistance;Risk;Roentgen Rays;Safety;side effect;Spectrum Analysis;Staphylococcus aureus;Staphylococcus epidermidis;Sterilization;Stromal Cells;success;Surface;surface coating;Testing;Torsion;Vancomycin;Water

PROJECT_TITLE: Synergistic anti-fouling coating and minimal systemic antibiotic injections for combating periprosthetic infections

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Clinical Research;Genetics;Kidney Disease;Organ Transplantation;Prevention;Rare Diseases;Transplantation

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Relevance: The pathogenesis of Nephrotic Syndrome (NS) is not completely known, and the role of HLA in disease pathogenesis has not been probed with state of the art next generation sequencing. Our studies will define the precise roles of genetic variations in HLA genes in the development and clinical course of NS in a multiethnic cohort of patients with primary, secondary and post-transplant NS. Data generated from the study will provide new insights into the risk factors and underlying mechanisms of NS, provide insight into the molecular basis for variability in the clinical response to therapy and disease recurrence following kidney transplantation, permit tailored treatment (precision medicine), and identify novel therapeutic targets for future clinical trials in NS.

PI_NAMEs: GBADEGESIN, RASHEED ADEBAYO (contact);JACKSON, ANNETTE MARIE

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: adaptive immunity;Adrenal Cortex Hormones;Alleles;Allografting;B-Lymphocytes;Blood specimen;Cardiovascular system;Child;Childhood;Clinical;Clinical Research;Clinical Trials;Code;cohort;Cohort Studies;Data;Defect;design;Development;Dialysis procedure;Disease;Disease remission;disorder risk;End stage renal failure;Enrollment;Ethnic Origin;experimental study;Failure;Functional disorder;Future;Gene Expression;Genes;Genetic;Genetic Transcription;Genetic Variation;genome sequencing;genome wide association study;Genotype;Haplotypes;healthcare burden;Histocompatibility Antigens Class I;HLA Antigens;IGA Glomerulonephritis;Immune;in silico;individualized medicine;Infection;insight;Kidney;kidney allograft;kidney biopsy;Kidney Diseases;Kidney Transplantation;Life;Link;Mediating;Membranous Glomerulonephritis;MHC Class II Genes;Midwestern United States;Modeling;Molecular;multi-ethnic;Nephrology;Nephrotic Syndrome;new therapeutic target;next generation sequencing;novel;Pathogenesis;Pathway interactions;Patients;Pattern;Peptides;peripheral blood;post-transplant;precision medicine;primary nephrotic syndrome;protein expression;Recurrence;Recurrent disease;Relapse;Renal glomerular disease;Resolution;response;Risk;Risk Factors;risk variant;Role;Secondary to;Steroid Resistance;Steroids;Stratification;Testing;Therapeutic Trials;Thromboembolism;Transplantation;treatment response;Untranslated RNA;Variant;whole genome

PROJECT_TITLE: Defining the Landscape of HLA Risk Alleles in Primary Nephrotic Syndrome and Post Kidney Transplant Recurrence


ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Life-threatening and incurable autoimmune syndromes affect millions of Americans and are often associated with exaggerated B lymphocyte activation and differentiation, and generation of self-reactive antibodies, which cause pain and damage in various parts of the body. In this application, we propose to investigate a novel role for an unconventional myosin family protein in regulating B cell homeostasis and antibody production. Insights from our study will reveal novel molecular mechanisms that control B cell function to prevent autoimmunity.

PI_NAMEs: GUPTA, NEETU  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Affect;American;anti-IgM;Antibodies;Antibody Formation;Antibody Response;Antigens;Autoantibodies;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;B cell differentiation;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Biochemical;Biological Assay;Body part;Body System;Cell Count;Cell Differentiation process;Cell Physiology;Cell Survival;Cells;Data;Development;Event;experimental study;fluorescence imaging;gain of function;Gene Expression;Gene Expression Profiling;Generations;Genetic;genetic regulatory protein;Genetic Transcription;Goals;Health;high resolution imaging;Homeostasis;humoral immunity deficiency;Hypergammaglobulinemia;Immunity;Immunologics;Immunoprecipitation;In Vitro;innovation;insight;Interleukin-6;Investigation;Life;Link;loss of function;Lymphocyte Activation;Mature B-Lymphocyte;Mediating;Messenger RNA;Mitochondria;Molecular;Molecular Abnormality;mRNA Decay;mRNA Stability;mRNA Transcript Degradation;Multiprotein Complexes;Mus;mutant;Myosin ATPase;novel;overexpression;Pain;pathogenic autoantibodies;Patients;Personal Satisfaction;Phenotype;plasma cell differentiation;Plasma Cells;Post-Transcriptional Regulation;posttranscriptional;prevent;Process;Production;Proliferating;Protein Family;Proteins;Publishing;Quality of life;Receptor Signaling;Regulation;Reporting;Research;response;RNA;Role;Scaffolding Protein;Self Tolerance;Signal Transduction;single-cell RNA sequencing;Site;Splenocyte;Splenomegaly;Surface;Syndrome;Testing;Tissue-Specific Gene Expression;Transcript;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Mice

PROJECT_TITLE: Novel unconventional myosins in B cell homeostasis

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Depression;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine;Serious Mental Illness

ORG_CITY: Los Angeles

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: NARRATIVE Our proposed global deep learning initiative unites international experts in artificial intelligence (AI), deep learning, psychiatry, and neuroimaging to discover brain signatures that predict which patients with major depressive disorder (MDD) will respond best to repetitive transcranial magnetic stimulation (rTMS). This first globally coordinated AI analysis of MDD brain data will help discover and understand biosignatures of MDD treatment response, in diverse cohorts worldwide.

PI_NAMEs: GOYA-MALDONADO, ROBERTO ;THOMPSON, PAUL M (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: 3-Dimensional;Address;Adverse effects;alternative treatment;anti-depressive agents;Artificial Intelligence;artificial intelligence method;artificial intelligence model;Australia;biobank;Biological Markers;biosignature;Brain;brain based;Brain Diseases;Brain imaging;brain magnetic resonance imaging;Brain Mapping;Brain region;China;Chinese;Classification;Clinical;Clinical assessments;Clinical Data;clinical predictors;Code;cohort;combat;convolutional neural network;Data;data exchange;data harmonization;Data Set;deep learning;deep learning model;depressive symptoms;Diagnosis;Diagnostic;Diffusion;disability;Disease;Disease remission;diverse data;Double-Blind Method;Electroconvulsive Therapy;Ensure;Ethics;experience;feature extraction;Functional Magnetic Resonance Imaging;Germany;Goals;Graph;Hamilton Rating Scale for Depression;Hybrids;imaging modality;improved;Individual;innovation;interest;International;Intervention;Learning;Legal;Magnetic Resonance Imaging;Major Depressive Disorder;Maps;Measures;Mental Depression;Methods;Modeling;Montgomery and Asberg depression rating scale;Morbidity - disease rate;MRI Scans;Multimodal Imaging;multimodal neuroimaging;multimodality;neuroimaging;neuromechanism;Neurosciences;novel;Outcome;outcome prediction;Participant;Patients;Pattern;Performance;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Population;precision medicine;predicting response;Prediction of Response to Therapy;Predictive Factor;predictive modeling;predictive signature;Privacy;Procedures;Psychiatry;Psychotherapy;Randomized, Controlled Trials;Recovery;repetitive transcranial magnetic stimulation;Research;Research Personnel;response;Sampling;Scanning;Screening procedure;Severities;Structure;Surface;Symptoms;Testing;tool;Training;transfer learning;treatment duration;treatment effect;Treatment outcome;Treatment Protocols;treatment response;treatment-resistant depression;United States National Institutes of Health;web site;Work

PROJECT_TITLE: Global Deep Learning Initiative to Understand Outcomes in Major Depression

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Depression;Mental Health;Neurodegenerative;Palliative Care

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE: By reducing stress in caregivers of persons with ADRD, the proposed work has the potential to drastically improve emotional well-being and physical health in not only caregivers, but also the people they care for. MASC teaches meditation, self-compassion and behavioral management skills without the burden associated with traditional in person or virtual meditation-based interventions. As such, there is tremendous opportunity for scalability and improved care for ADRD caregivers across USA.

PI_NAMEs: RITCHIE, CHRISTINE S (contact);VRANCEANU, ANA-MARIA

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Adherence;Adult;Aggressive behavior;Agitation;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease related dementia;Anxiety;anxiety symptoms;Behavior;behavior change;Behavioral;Behavioral Sciences;Benchmarking;Bypass;care giving burden;care recipients;caregiver stress;Caregivers;Caring;Clinical Trials;clinically relevant;community center;community partners;comparison control;Compassion;Complex;Data;dementia care;Dementia caregivers;depressive symptoms;design;Dissemination and Implementation;Distress;Education;Educational process of instructing;Effectiveness;effectiveness trial;emotion regulation;emotional distress;Empathy;Enrollment;Ensure;ethnic minority;evidence base;experience;Feasibility Studies;feasibility testing;Focus Groups;follow-up;Fostering;Funding;Geography;Goals;Guilt;Health;Health education;Home;Hybrids;improved;Individual;Intervention;Interview;Language;Loneliness;loved ones;Massachusetts;Meditation;Mental Depression;mindfulness;Modality;Modeling;Morbidity - disease rate;mortality;Outcome;Patient Self-Report;Patients;Perception;Personal Satisfaction;Persons;physical conditioning;Positioning Attribute;Procedures;programs;psychologic;Public Health;racial minority;Randomized;recruit;Regimen;Reporting;Research;Risk;Sampling;Science;secondary outcome;Self Efficacy;self-compassion;Services;Signal Transduction;Single-Blind Study;skills;Social support;Stress;stress management;stress reduction;Structure;Support Groups;therapy development;Time;United States National Institutes of Health;uptake;video delivery;virtual;virtual delivery;web platform;Well in self;Work

PROJECT_TITLE: The Mindful and Self-Compassionate Care Program (MASC): Reducing Stress for Caregivers of Persons with Dementia


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Asthma;Clinical Research;Endocrine Disruptors;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: NARRATIVE This study will determine if common chemicals in our environment affect adolescent lung health, including lung function and inflammation. These chemicals can also affect hormones like testosterone and estrogen therefore, we will determine if they affect male and female lung health differently.

PI_NAMEs: SATHYANARAYANA, SHEELA  (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Academy;Address;Adolescence;Adolescent;Adolescent Development;Affect;Age;Airway Disease;airway inflammation;Albuterol;Allergic;androgenic;anogenital distance;Asthma;Attenuated;Behavioral;Biological;biological sex;Biology;Chemical Exposure;Chemicals;Childhood;clinical predictors;cohort;Data;Development;diagnostic tool;Disproportionately impacts women;early childhood;Economic Burden;Endocrine disruption;Endocrine Disruptors;Environment;estrogen disruption;estrogenic;Estrogens;Exhalation;Exposure to;externalizing behavior;Female;Forced expiratory volume function;Gonadal Steroid Hormones;health management;Homeostasis;Hormonal;Hormones;improved;infancy;Infant;Infant Development;Inflammation;injured airway;insight;Longitudinal Studies;lung health;male;Measures;Mediating;Mediator;Medicine;Modification;Morbidity - disease rate;Nitric Oxide;novel;Outcome;Pathway interactions;Phase;Phenols;phthalates;Play;Policies;Positioning Attribute;predictive tools;Pregnancy;prenatal;prenatal exposure;Preventive care;Production;programs;pulmonary function;Pulmonary Inflammation;Questionnaires;reproductive;Research;respiratory health;Risk;Role;Serum;sex;sex as a biological variable;Sex Differences;sex disparity;sexual dimorphism;Site;Spirometry;Steroid biosynthesis;steroid hormone;Steroids;Testing;Testosterone;Time;United States National Institutes of Health;urinary;Urine;Visit;Vital capacity;Wheezing

PROJECT_TITLE: TIDES III: Endocrine Disruption, Hormones, and Sex Differences in Adolescent Airway Health

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative In this proposal we will investigate the stepwise cellular and genetic changes that control central nervous system development, regeneration and aging using a unique long-lived invertebrate model organism, Botryllus schlosseri, that reproduces both sexually as chordates and asexually as invertebrates and undergoes weekly degeneration and regeneration of its CNS during its adult life. Focusing on Botryllus brain cells we will characterize the genes and programs involved in the development of sexually produced larval brains, and asexually produced adult brains, isolate neural stem cells, and determine the difference between brain development and regeneration. Additional comparisons between the neural stem cells of young (< 6 months) and old (> 7 years) Botryllus colonies, will shed light on the process of neurodegeneration and neural stem cell aging.

PI_NAMEs: VOSKOBOYNIK, AYELET  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Adult;adult neurogenesis;adult stem cell;Affect;Age;age related;age related neurodegeneration;aged;Aging;aging brain;Alzheimer's Disease;Amyloid beta-Protein Precursor;Animals;Anti-sense RNA;asexual;Atlases;Behavioral;Biological Assay;Biological Metamorphosis;Biological Models;Brain;brain cell;Candidate Disease Gene;Cell Aging;Cell Count;Cell Lineage;Cell Separation;Cell Transplantation;Cells;Central Nervous System;Chordata;circadian;circadian pacemaker;Clinical Trials;Clonal Expansion;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;complement C2a;Dementia;design;Development;differential expression;Disease;DNA;DNA Sequence Alteration;Early Onset Alzheimer Disease;Elements;Epigenetic Process;Exhibits;Failure;fitness;Frequencies;Gene Expression;Generations;Genes;Genetic Variation;Genome;Genotype;germline stem cells;Homologous Gene;Human;indexing;Individual;Invertebrates;Larva;Life;life history;life span;Link;Mediating;model organism;Molecular;Morphology;Mutation;Natural regeneration;Nerve Degeneration;nerve stem cell;Nervous System;nervous system development;Neurodegenerative Disorders;neuron regeneration;Neurons;Organ;Organism;Pathogenesis;Pathway interactions;Pattern;Phenotype;Population;preclinical trial;presenilin-1;Process;progenitor;programs;prospective;Publishing;Regenerative Medicine;reproductive;Research;response;Role;Sampling;Secondary to;self organization;self renewing cell;self-renewal;Senile dementia;sensory stimulus;Sexual Reproduction;single-cell RNA sequencing;stem cell aging;stem cell expansion;stem cell population;stem cell self renewal;stem cells;Stimulus;Study models;Testing;Time;tissue regeneration;Tissues;trait;transcriptome;transcriptomics;Transplantation;Urochordata;Vertebrates

PROJECT_TITLE: Evolutionary Conserved Mechanisms that Control Central Nervous System Development Regeneration and Degeneration

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative Mutations increase in male gametes as men get older, leading to older fathers being more likely to have children with a genetic disease and creating a reproductive concern for older men. Our studies elucidate involved mechanisms with a long term goal of reducing risk of genetic disease in children born to older fathers through intervention.

PI_NAMEs: KRAIG, ELLEN  (contact)

PROGRAM_OFFICER_NAME: WANG, FEI

PROJECT_TERMS: Address;Age;age effect;age related;Aging;Animals;autism spectrum disorder;Automobile Driving;Base Excision Repairs;Biological;Birth;Birth Rate;Cell division;cell type;Cells;Child;Child Health;Chromatin;chromatin protein;Chromosomes;Chronic;cytotoxic;Data;Diagnosis;DNA Damage;DNA Repair;DNA sequencing;driving force;Embryonic Development;endonuclease;Enzymes;Epidemic;Fathers;Fertility;Frequencies;Generations;Genes;Genetic;Genetic Diseases;genome integrity;Genotype;Germ Cells;Germ Lines;Germ-Line Mutation;Goals;Heterozygote;human old age (65+);Immunofluorescence Microscopy;Immunoprecipitation;in vivo;Infertility;inhibitor;innovation;insight;Intervention;Knock-out;Knockout Mice;Label;Life;Link;male;Mass Spectrum Analysis;MDM2 gene;Mediating;Meiosis;men;Methodology;Methods;middle age;Modeling;multicatalytic endopeptidase complex;Mus;Mutagenesis;mutant;Mutation;National Institute of Child Health and Human Development;novel;old mice;older men;overexpression;Paint;Paternal Age;Phosphorylation;Physiology;Play;Population;postmitotic;preservation;Proteins;Recurrence;repaired;Reproduction;reproductive;reproductive senescence;Research;Risk;Risk Factors;Risk Reduction;Role;senescence;Signal Transduction;Site;sperm cell;Spermatids;Spermatocytes;Spermatogenic Cell;stem cell aging;Testing;TP53 gene;Transcription Coactivator;transcription factor;Transgenic Mice;Transgenic Organisms;Tumor Suppressor Proteins;Ubiquitination;young adult;young man

PROJECT_TITLE: The Paternal Age Effect - Enhanced Germ Cell Mutagenesis Modulated by the TRP53/APE1/MDM2 Tumor Suppressor Axis


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Microbiome;Nutrition;Pancreatic Cancer;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative Gastrointestinal toxicity often limits the amount of radiation that can be given to cancer patients. Our studies will determine how fasting protects small intestinal epithelial cells from high dose radiation therapy (RT) with the ultimate goal of mitigating deleterious side effects associated with RT so that dose escalation regimens can be employed for efficient tumor cell killing.

PI_NAMEs: PIWNICA-WORMS, HELEN M (contact);RAI, KUNAL

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Animals;Automobile Driving;Bacteria;beta-Hydroxybutyrate;Cancer Patient;cell killing;Cell Separation;Cells;ChIP-seq;Chromatin;Clinical;Coenzyme A;Data;Dose;Enhancers;Epigenetic Process;epigenome;epigenomics;Epithelial Cells;experimental study;Fasting;gastrointestinal;Gene Expression;Genes;Genetic Transcription;Goals;gut microbiome;HDAC4 gene;Histone H3;Histone H4;improved;insight;intestinal crypt;intestinal homeostasis;Intestines;Ionizing radiation;ketogenesis;Ketone Bodies;Knock-out;Lysine;Malignant neoplasm of pancreas;Mediating;Metabolic;microbial;microbiome alteration;mimetics;mouse model;Mus;neoplastic cell;Normal tissue morphology;novel;Organ;Outcome;pancreas radiation therapy;Patients;preservation;Probiotics;Production;programs;promoter;protective effect;Quality of life;Radiation;Radiation Dose Unit;Radiation induced damage;Radiation Protection;Radiation therapy;Radiation Toxicity;radioprotected;Reaction;Regimen;repaired;Resolution;response;side effect;single cell analysis;Small Intestinal Goblet Cell;Small Intestines;stem cells;Testing;Toxic effect;transcriptome sequencing

PROJECT_TITLE: Mechanisms of fasting-induced radioprotection of small intestinal epithelial cells

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Calcium pyrophosphate deposition disease (CPDD) is a common and painful form of arthritis with no specific or effective therapies. Genetic abnormalities in a protein called osteoprotegerin were recently discovered to cause familial forms of CPDD. In this proposal, we characterize a novel animal model carrying this mutation and explore the mechanisms through which osteoprotegerin mutations cause CPDD with the ultimate goal of developing new therapies for this disease.

PI_NAMEs: MBALAVIELE, GABRIEL ;ROSENTHAL, ANN K (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Adult;Affect;Age;age related;Alkaline Phosphatase;American;Amino Acids;Animal Model;Arthritis;articular cartilage;Back;bone;bone mass;Calcium Pyrophosphate;Calcium pyrophosphate deposition disease;Cartilage;Chondrocytes;Clinical;Code;Conditioned Culture Media;CRISPR/Cas technology;Crystal Formation;Data;Development;Diphosphates;Disease;drug development;Early identification;early onset;effective therapy;Elderly;Exhibits;extracellular;Feedback;genetic manipulation;Genetically Engineered Mouse;Goals;Human;In Vitro;in vivo Model;Individual;Induced Mutation;Injury;innovation;joint injury;Joints;kindred;Knock-in Mouse;loss of function;Mediating;Molecular;Molecular Abnormality;mouse model;Mus;mutant;Mutation;new therapeutic target;NF-kappa B;novel;novel therapeutics;older patient;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteopenia;Pain;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Phenotype;phosphoric diester hydrolase;Population;Pre-Clinical Model;preclinical study;premature;prevent;Process;Production;Proteins;Public Health;Publishing;pyrophosphatase;receptor;receptor binding;Receptor Inhibition;Recombinants;Reporting;Risk Factors;Role;Source;stem;subchondral bone;Tail;Terminator Codon;theories;Therapeutically Targetable;Tissues;TNFRSF11B gene;TRANCE protein;Translations;Tumor necrosis factor receptor 11b;Work

PROJECT_TITLE: Molecular pathways of calcium pyrophosphate deposition disease

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Machine Learning and Artificial Intelligence;Pediatric;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Bicuspid aortic valve repair is an evolving surgical treatment for aortic regurgitation that preserves native valve tissue and circumvents risks and quality of life concerns associated with conventional aortic valve replacement in young adults. The proposed research develops new multimodal four-dimensional (three dimensional + time) image analysis technology that automatically identifies the patient-specific valve defects that cause aortic regurgitation and enables the surgeon to pre-operatively visualize the motion of the bicuspid aortic valve in order to plan a valve repair surgery. This technology could potentially reduce variability in bicuspid aortic valve repair planning across institutions and increase utilization of repair as an alternative to valve replacement in young adults.

PI_NAMEs: POUCH, ALISON MARIE (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: 3-Dimensional;4D Imaging;Address;Algorithms;alternative treatment;Anatomic Models;Anatomy;Angiography;Anticoagulation;Aorta;Aortic Valve Insufficiency;aortic valve replacement;Artificial Heart;automated algorithm;automated assessment;automated segmentation;bicuspid aortic valve;Bioprosthesis device;Cessation of life;Characteristics;clinical imaging;comorbidity;Competence;Complex;Computer Assisted;congenital heart abnormality;Control Groups;conventional therapy;dashboard;Data;Defect;design;Detection;Devices;diagnostic tool;emerging adult;Engineering;Evaluation;Four-dimensional;Geometry;Goals;Heart;Heart failure;Heart Valve Diseases;Heart Valves;Hemorrhage;Image;Image Analysis;image visualization;imaging modality;in silico;innovation;Institution;interactive visualization;Intervention;Intuition;Knowledge;machine learning algorithm;machine learning method;Manuals;Maryland;Measurement;Mechanics;Methods;Modality;Modeling;Morphology;Motion;multi-atlas segmentation;multidisciplinary;Multimodal Imaging;multimodality;Operative Surgical Procedures;Outcome;Patients;Pennsylvania;Phenotype;Physiological;premature;preservation;prevent;Procedures;Progressive Disease;Quality of life;reconstruction;repair model;repair strategy;repaired;Reproducibility;Research;Resolution;Risk;risk stratification;Standardization;Statistical Models;statistics;Surgeon;System;Technology;temporal measurement;Testing;Time;Tissues;tool;touchscreen;Transesophageal Echocardiography;two-dimensional;Universities;valve replacement;Variant;Visualization;Work;X-Ray Computed Tomography;young adult

PROJECT_TITLE: 4D Multimodal Image-Based Modeling for Bicuspid Aortic Valve Repair Surgery

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Obesity is a major public health problem that increases the risk for type 2 diabetes, cardiovascular disease, and certain forms of cancer. The studies proposed in this application are designed to understand the role of peroxisomal metabolism of branched chain fatty acids in activating brown fat-mediated thermogenesis, a potential strategy to treat obesity.

PI_NAMEs: LODHI, IRFAN J (contact);SEMENKOVICH, CLAY F.

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Adipocytes;Adipose tissue;Animals;ATP Synthesis Pathway;Biochemical;branched chain fatty acid;Branched-Chain Amino Acids;Brown Fat;Cardiovascular Diseases;Catabolism;Cell Culture Techniques;Coenzyme A;Consumption;CRISPR/Cas technology;design;diet-induced obesity;Dietary Intervention;energy balance;Energy Metabolism;Enzymes;Fatty acid glycerol esters;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Fatty-acid synthase;Futile Cycling;gain of function;Gene Expression;Genes;Glucose;Impairment;in vivo;innovation;Insulin Resistance;Knock-out;Knockout Mice;Label;lipid biosynthesis;lipid metabolism;loss of function;LoxP-flanked allele;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Metabolism;Mitochondria;Mitochondrial Membrane Protein;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;Norepinephrine;novel;novel therapeutic intervention;Obesity;Organelles;overexpression;oxidation;Oxygen Consumption;Pathway interactions;peroxisome;Physiological;Process;Production;Proteins;Public Health;Regulation;Respiration;response;Risk;Role;sensor;Site;Stimulus;synthetic protein;Temperature;Testing;Thermogenesis;uncoupling protein 1;Up-Regulation;Valine;Work

PROJECT_TITLE: BCFA Metabolism and the Regulation of Energy Balance

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: Amherst

ORG_NAME: FRONTIER SCI & TECHNOLOGY RSCH FDN, INC

PHR: Project Narrative Women living with HIV (WLWH) have a higher risk for acquisition, persistence, and progression of cervical human papillomavirus (HPV) to precancerous lesions, which, in the absence of effective screening and treatment services, can progress to invasive cancer at five-to-six times higher rates than in women without HIV. The overall goal of the HIV/Cervical Cancer Prevention `CASCADE' Clinical Trials Network is to conduct pragmatic clinical trials evaluating the effectiveness of clinically proven interventions to optimize the cervical cancer screening, management, and pre-cancer treatment cascade for WLWH. The CASCADE Coordinating Center will (i) provide overall network coordination and facilitate scientific review of network clinical trial concepts and protocols, (ii) provide centralized support for data management for network clinical trials, and (iii) conduct independent risk-appropriate auditing of network clinical trials.

PI_NAMEs: SIMINSKI, SUZANNE M. (contact)

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;antiretroviral therapy;Area;base;Biometry;cancer invasiveness;cancer prevention;cascade genetic testing;Cervical;cervical cancer prevention;Cervical Cancer Screening;Clinical effectiveness;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;cost;cost effective;Data;Data Analyses;data management;Data Reporting;design;Detection;Division of Cancer Prevention;effectiveness evaluation;Effectiveness of Interventions;effectiveness/implementation design;Emergency Situation;Environment;Goals;health disparity;Health Services Accessibility;high risk;HIV;HPV positive;Human Papillomavirus;implementation strategy;improved;Incidence;Informatics;Information Technology;Infrastructure;innovation;Intervention;Leadership;Lesion;low and middle-income countries;Malignant neoplasm of cervix uteri;Measurement;Methodology;multidisciplinary;operation;Phase;Positioning Attribute;Pragmatic clinical trial;premalignant;prevention clinical trial;programs;protocol development;Protocols documentation;Recurrence;Research;Resource-limited setting;Resources;Risk;scale up;screening;screening services;Site;Specific qualifier value;support network;treatment services;United States;uptake;virtual;Woman;women's prevention;women's treatment

PROJECT_TITLE: CASCADE Coordinating Center


ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

PHR: RELEVANCE TO PUBLIC HEALTH Inflammatory responses to stroke cause secondary neuronal damage, therefore dampening inflammation may lead to improved outcomes after stroke. The CD200- CD200R signaling axis has an important inhibitory role in post-stroke inflammation. This proposal will study the effects of CD200-CD200R signaling on peripheral immune cell mobilization, and will potentially identify new effective therapeutic targets for stroke.

PI_NAMEs: LIU, FUDONG  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Adult;Affect;aged;Aging;Area;Astrocytes;behavioral outcome;Binding;Blood;Bone Marrow;Brain;brain cell;brain endothelial cell;Brain Ischemia;cadherin 5;Calcium;CD 200;Cells;Central Nervous System Diseases;Cerebral endothelium;Chimera organism;comparison intervention;conditional knockout;Coupling;cytokine;Data;Disease;Elderly;Endothelium;enolase;excitotoxicity;Failure;Female;Flow Cytometry;Glial Fibrillary Acidic Protein;Glycoproteins;Green Fluorescent Proteins;Immune;immune activation;Immune response;Immunologic Receptors;improved outcome;in vivo;Infarction;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Injury;Interruption;Ischemic Brain Injury;Ischemic Stroke;knock-down;Knock-out;Knockout Mice;Leucocytic infiltrate;Leukocytes;Lifting;Ligands;LoxP-flanked allele;Lymphocyte;Macrophage;male;Mediating;Membrane;Microglia;Middle Cerebral Artery Occlusion;migration;mouse model;Mouse Protein;Mus;Myeloid Cells;neuroinflammation;Neurons;neutrophil;Organ;Outcome;overexpression;Oxidative Stress;Pathway interactions;Peripheral;Play;post stroke;pre-clinical;prevent;Process;promoter;Public Health;receptor;Research;Rest;Role;Signal Transduction;Stroke;stroke outcome;stroke patient;stroke therapy;Testing;therapeutic target;therapeutically effective;Time;tissue injury;Transfection;Transgenic Mice;Translating;Transplantation;Up-Regulation;Virus

PROJECT_TITLE: CD200 signaling mediates the interactions of neurons and endothelia with circulating leukocytes in stroke

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Complementary and Integrative Health;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;Dietary Supplements;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Maternal Health;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Pregnancy;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: NUTRITION

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Fetal alcohol spectrum disorders (FASD) affect 2-5% of the United States general population and up to 31% in some communities in South Africa; yet there is little known about the nutritional, genetic, or nutrigenetic risk factors that contribute to the susceptibility of an FASD diagnosis. This application proposes utilizing existing dysmorphology, neurobehavioral, biological (circulating nutrient concentrations) and genetic data from a population-based cohort to determine the independent maternal nutritional and nutrigenetic contributions to the susceptibility and severity of physical dysmorphology and neurodevelopmental abilities that constitute traits of FASD. This application will contribute an innovative understanding to the susceptibility of children regarding multiple physical and developmental traits associated with FASD and provide insight into future candidate gene studies and possible nutritional interventions to remediate the adverse effects of prenatal alcohol exposure in children and adults.

PI_NAMEs: HASKEN, JULIE  (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: Adult;Adverse effects;adverse outcome;Affect;alcohol consumption during pregnancy;Alcohol dependence;alcohol exposure;Alcohols;Alleles;alpha-Linolenic Acid;Animal Model;Animals;Area;bead chip;Betaine;Biological;Birth;Calcium;Candidate Disease Gene;candidate identification;Carbon;Central Nervous System;Child;Choline;cohort;Communities;Complex;Copper;Coupled;craniofacial;Custom;Data;Data Analyses;Data Set;design;Development;Developmental Delay Disorders;Diagnosis;Diet;dietary;Dietary intake;Dietary Intervention;dimethylglycine;Disease;Docosahexaenoic Acids;docosapentaenoic acid;Dysmorphology;Educational workshop;Eicosapentaenoic Acid;Environment;Equation;Ethanol Metabolism;Etiology;experience;Face;Fatty Acids;Fellowship;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Development;Folic Acid;Frequencies;frontier;Future;gene interaction;General Population;Genes;Genetic;genetic epidemiology;Genetic Polymorphism;Genetic Predisposition to Disease;genetic risk factor;genome wide association study;Genomics;Genotype;Goals;Growth;Growth and Development function;Homocysteine;Individual;individual variation;Infant;innovation;insight;Instruction;Intervention;Iron;Leadership;Longitudinal cohort;Measurement;Mediating;Metabolism;Methods;micronutrient deficiency;Micronutrients;Modeling;mother nutrition;Mothers;multi-ethnic;multidisciplinary;neurobehavioral;Neurocognitive;Neurocognitive Deficit;Neurological outcome;novel;Nutrient;nutrition related genetics;Nutritional;nutritional genomics;Nutritional status;offspring;Omega-3 Fatty Acids;Outcome;Pathway interactions;Phenotype;phenotypic data;Plasma;polygenic risk score;Population;population based;post intervention;Postdoctoral Fellow;postnatal;precision nutrition;Predisposition;Pregnancy;Pregnant Women;prenatal;Prevalence;Prevention strategy;protective allele;Province;recruit;Regulator Genes;remediation;Research;Research Personnel;Resources;Risk;Risk Factors;risk variant;saliva sample;Sampling;Severities;Single Nucleotide Polymorphism;skeletal;skills;South Africa;Standardization;Statistical Data Interpretation;Techniques;Testing;theories;Training;trait;United States;Variant;virtual;Vitamin B6;Zinc

PROJECT_TITLE: Physical and Neurocognitive Outcomes Among Children with Fetal Alcohol Spectrum Disorder Outcomes (FASD): The Contribution of Maternal Nutrition and Nutrigenetic Risk Factors


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

PHR: RELEVANCE The goal of this grant is to uncover the molecular mechanisms that mediate pathogenesis downstream of a large number of genes strongly implicated in Autism Spectrum Disorders (ASD). A leading hypothesis in the field is that ASD genes converge on common pathways, however the molecular details of this remains unknown. As such, a better understanding of the fundamental mechanisms shared between ASD genes, and how pathogenic variants alter these pathways could be expected to paradigm shifting. We anticipate this work will yield novel insights into how human genetic mutations are associated with ASD and whether there are common downstream perturbations between different ASD genes.

PI_NAMEs: SODERLING, SCOTT H (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Animals;Anxiety;autism spectrum disorder;Axon;Behavior;behavioral outcome;Biological;Biology;Biotin;Brain;Brain Diseases;Buffers;burden of illness;cell type;Cells;Chimeric Proteins;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Compensation;Complex;Coupled;Data;Development;Disease;disorder risk;DNA Sequence Alteration;driver mutation;Engineering;epigenome;Etiology;Exhibits;Face;Functional disorder;Future;Gene Expression;gene interaction;Genes;Genetic;Genetic Diseases;Genome engineering;Genotype;Goals;Grant;Human;Human Genetics;in vitro Assay;in vivo;in vivo evaluation;Injections;innovation;insight;Knowledge;Label;Maps;Measures;Mediating;Methods;Modeling;Molecular;Molecular Analysis;Mus;Mutation;Neurons;new technology;novel;novel strategies;Outcome;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Phenotype;prediction algorithm;protein complex;protein protein interaction;protein structure prediction;Proteins;Proteome;Proteomics;Publishing;repetitive behavior;response;risk variant;segregation;single cell analysis;single cell sequencing;single-cell RNA sequencing;Structure;Subcellular structure;success;Synapses;Synaptic plasticity;Synaptic Transmission;Testing;Tissues;Ultrasonics;Variant;Viral;vocalization;Work

PROJECT_TITLE: Molecular Analysis of Developmental Brain Disorders Associated with Synaptic Pathology


NIH_SPENDING_CATS: Aging;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH This research will provide empirical evidence on how racism and intersecting systems of oppression manifest at the individual and neighborhood levels to create structural adversity that, over the life-course, become psychologically and physiologically embedded and perpetuate racialized disparities in health. Specifically, we will innovatively utilize a racially and socioeconomically diverse cohort of midlife adults followed over the course of 30+ years beginning in childhood/early adolescence that will provide a broad array of social, psychosocial, and structural determinants of health captured repeatedly across the lifespan. This will be the first study to comprehensively determine the impact of structural adversity on stress regulation, accelerated aging, and mental health outcomes and will do so by linking these cohort data with (1) new survey and biospecimen data, (2) aggregated Census data to capture neighborhood ethnic-racial inequality, and (3) contextualized data from in-depth interviews eliciting narratives that will also capture the generational context of structural adversity, stress incurred, and ways of contending with racialized experiences.

PI_NAMEs: KOBOR, MICHAEL ;LEWIS, CRYSTAL FULLER;PAHL, KERSTIN  (contact)

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: accelerated epigenetic aging;Adult;Adverse event;Age;age acceleration;Anxiety;Area;Biological;biological adaptation to stress;Biological Markers;biopsychosocial;Black American;Black race;Buffers;Censuses;Child;Childhood;Chronic;Chronic stress;cohort;Cohort Studies;Communities;Complement;COVID-19 pandemic;Data;Development;Discrimination;disparities in morbidity;Disparity;DNA Methylation;early adolescence;Ecosystem;emerging adulthood;Epigenetic age;epigenetic aging;epigenetic clock;Epigenetic Process;ethnic difference;Ethnic Origin;experience;Exposure to;Generations;Goals;grandparent;Health;health disparity;health goals;Health Status;Hydrocortisone;Immune system;Individual;Individual Differences;Inequality;inequitable distribution;innovation;Institution;Intervention;Interview;Latinx;Life Cycle Stages;Life Expectancy;Life Experience;life span;Link;Longitudinal cohort;Measures;Mediating;Mental Depression;Mental Health;Methods;middle age;Modification;Neighborhoods;Outcome;Parents;Pathologic;Patient Self-Report;Personal Satisfaction;Persons;phenomenological models;physical conditioning;Physiological;Policies;post-traumatic stress;protective factors;psychologic;psychological distress;psychosocial;public health research;Race;racial difference;racial discrimination;racial disparity;racial diversity;racial health disparity;racism;rate of aging;Regulation;Research;Research Methodology;resilience;Risk;Salivary;Sampling;Signal Transduction;social;Social Conditions;social determinants;Social Environment;social stigma;social structure;Social support;socioeconomic disadvantage;socioeconomic disparity;socioeconomics;Stress;stressor;structural health determinants;Structural Racism;Surveys;System;Systems Theory;Testing;tool;traumatic stress;United States;Validation;Variant;young adult

PROJECT_TITLE: Structural Adversity and Life-Course Social Determinants of Stress Regulation and Epigenetic Aging in Midlife Adults


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Coronaviruses;Mental Health;Neurosciences

ORG_CITY: HANOVER

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: NARRATIVE (Relevance)  This project will produce infrastructural research resources that will greatly facilitate progress in functional brain imaging research on a wide range of topics in clinical neuroscience, brain aging, and basic cognitive neuroscience. It will enrich future research by embedding new data into a standardized hyperalignment framework, which provides more detailed information about the functional architecture of individual brains and affords analysis and data sharing at the spatial scale for fine-grained information.

PI_NAMEs: GOBBINI, MARIA I;HAXBY, JAMES V (contact)

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: affective neuroscience;Aging;aging brain;Algorithms;Alzheimer's Disease;Anatomy;Architecture;Atlases;behavior prediction;Brain;Brain imaging;Clinical;cognitive neuroscience;cognitive testing;Communities;Computer software;connectome;Consumption;cortex mapping;cost effective;Data;Data Aggregation;data platform;Data Set;data sharing;Databases;experimental analysis;flexibility;Functional Magnetic Resonance Imaging;Generations;Grain;High-dimensional Modeling;Hour;Human;Individual;Individual Differences;information model;Infrastructure;Inosine Dialdehyde;Maps;Modeling;Molecular Conformation;movie;neuroimaging;Neurosciences;open source;Participant;Personality Tests;Population;Population Analysis;preservation;Principal Investigator;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;response;Rest;Sampling;Scanning;Software Tools;Space Models;Standardization;Structure;Surface;System;Time;tool;Work

PROJECT_TITLE: Infrastructure for hyperaligning fMRI data and estimating functional topographies

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This project will uncover the distinct neuronal pathways through which dopamine drives both action-outcome and habit learning. Given that substance use disorders and other psychiatric diseases are characterized by ill-informed decisions that lack consideration of future consequences, resulting from disrupted action-outcome learning and maladaptive habits, in the longer term this work could lead to novel targets for treating pathological decision making.

PI_NAMEs: WASSUM, KATE M (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Address;Amygdaloid structure;Anxiety;autism spectrum disorder;Basic Science;Behavior;Behavior assessment;Behavior Control;Brain;Cell Nucleus;cell type;Cognitive;comparative;Coupled;Data;Decision Making;Desire for food;Disease;Dissection;Dopamine;dopaminergic neuron;Emotional;Equilibrium;Evaluation;Event;Exposure to;flexibility;Foundations;Fright;Functional disorder;Future;Goals;habit learning;Habits;innovation;Investigation;Knowledge;Lateral;Learning;learning outcome;Lesion;Mediating;Memory;Mental Depression;Mental disorders;Midbrain structure;Modeling;Modernization;Monitor;Motivation;Neurobehavioral Manifestations;Neuromodulator;neuronal circuitry;Neurons;Neurosciences;neurotransmission;novel;Obesity;Obsessive-Compulsive Disorder;Operant Conditioning;Optics;optogenetics;Outcome;Pathologic;Pathway interactions;Policies;prospective;Psychological reinforcement;response;Rewards;Role;Schizophrenia;sensor;Signal Transduction;Substance Use Disorder;success;System;Testing;theories;tool;Ventral Tegmental Area;Work

PROJECT_TITLE: Do dopamine neurons mediate both goal-directed and habit learning via distinct projections to basolateral versus central amygdala?

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Asthma;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: MISCELLANEOUS

PHR: Project Narrative Socioeconomic and racial-ethnic inequalities in obesity are well documented in the literature and it is suggested that these disparities are due, to some extent, to inequalities in the built and natural environments and housing quality. We propose to use the redevelopment of a public housing project as a natural experiment to examine the short-term impact of construction- related disruptions to the built and natural environment on residents’ BMI and related health outcomes.

PI_NAMEs: SHIER, VICTORIA  (contact)

PROGRAM_OFFICER_NAME: BERRIGAN, DAVID

PROJECT_TERMS: Address;Air;Air Pollution;Alcohol consumption;Asthma;asthma exacerbation;authority;Body mass index;Body Weight;built environment;Cardiovascular system;Cities;cohort;Cohort Studies;Color;Communities;Control Groups;cost;Data;Data Collection;Deterioration;Development;Diet;Disparity;Environment;ethnic disparity;experience;Experimental Designs;Food Access;Funding;Future;Goals;Green space;Health;health assessment;Health behavior;Health behavior and outcomes;health disparity;Health Food;Health Status;healthy lifestyle;Heterogeneity;Home;Housing;Hypertension;improved;Income;Inequality;Jogging;Life Cycle Stages;Lighting;Link;Literature;Los Angeles;Low income;Malignant Neoplasms;Mental Health;minority communities;Minority Groups;Modeling;mortality;Natural experiment;Neighborhoods;Noise;noise pollution;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;Ownership;Pattern;Phase;Physical activity;Positioning Attribute;Public Housing;Race;randomized, controlled study;recruit;Reduce health disparities;Research;Risk;Role;Safety;Services;Site;Sleep;Smoking;sociodemographics;socioeconomics;Stress;Stroke;Subgroup;Surveys;Time;timeline;Urban Community;walkability

PROJECT_TITLE: Redeveloping Low-Income Communities Of Color: Impacts On Residents' Obesity And Related Health Behaviors