NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Contraception/Reproduction;Maternal Health;Pediatric;Prevention;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed research directly addresses a long-acknowledged scientific gap: the absence of rigorously conceptualized and evaluated psychometric instruments to measure women’s desires, feelings, and preferences around a potential future pregnancy. The novel, validated Desire to Avoid Pregnancy (DAP) scale represents a leap forward in measurement that will generate new knowledge with its application in newly available longitudinal, population-based surveys, which we will use to investigate the role of pregnancy intentions on the causal pathway to unintended pregnancy, short IPIs, and adverse maternal and birth outcomes. The insights gained and development of innovative extensions of the DAP instrument will facilitate the use of rigorous, meaningful measures in future research, and guide us to public health and clinical interventions that can more successfully prevent unintended pregnancy and short interpregnancy intervals and mitigate their health effects.

PI_NAMEs: ROCCA, CORINNE H. (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Accounting;Address;Adopted;Adoption;Adverse effects;adverse maternal outcomes;Affect;Affective;aged;avoid pregnancy;Behavior;Birth;Birth Intervals;Birth Order;Child;child bearing;Childbirth;Clinical;clinical care;Code;Cognitive;Communities;contextual factors;Contraceptive Usage;Couples;Data;Development;effective intervention;Equation;Ethnic Origin;evidence base;Feeling;Future;Goals;Grouping;Health;improved;innovation;insight;instrument;Intention;Intervention;Investigation;Knowledge;Lead;Left;longitudinal analysis;Longitudinal Studies;Longitudinal Surveys;Low Birth Weight Infant;Maternal and Child Health;Maternal Health;Measurement;Measures;Mediating;Mediation;Methodology;Methods;Modeling;Nature;neonatal health;neonatal outcome;novel;Outcome;Pathway interactions;person centered;Personal Satisfaction;Physiological;population based;preference;Pregnancy;Pregnancy Interval;Premature Birth;prepregnancy;preservation;prevent;prospective;Psychometrics;Public Health;public health research;Race;reproductive;Research;Research Design;Research Personnel;Research Project Summaries;response;Risk;Risk Factors;Role;Science;Shapes;Social Environment;social factors;Standardization;Surveys;theories;therapy development;Time;tool;Uncertainty;unintended pregnancy;United States;US State;Woman;Women's Group

PROJECT_TITLE: Advancing Innovative Measurement of Pregnancy Preferences with Longitudinal Data

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Genetics;Osteoarthritis

ORG_CITY: STRATFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED

ORG_STATE: NJ

PHR: Project Narrative  The objective of this project is to investigate cellular and molecular mechanisms that regulate synovial joint development. In particular, this study provides novel insights into mechanisms underlying joint progenitor cell function and cavitation. Understanding dynamics of hyaluronic acid (HA) metabolism regulating joint formation during embryonic development will provide novel insights into creation of superior therapeutic tools to treat degenerative joint conditions such as osteoarthritis (OA) in a clinically-relevant manner (i.e., HA injection).

PI_NAMEs: KIM, MINWOOK  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Ablation;Adult;Anatomy;Appearance;articular cartilage;Back;Biochemical;Biochemistry;Biological Assay;Biological Process;Biology;Biomedical Engineering;capsule;career;cartilage regeneration;cartilaginous;CD44 gene;Cell Adhesion Molecules;Cell Line;Cell Separation;Cell surface;Cells;clinically relevant;Complement;Cytoskeletal Modeling;Data;Degenerative polyarthritis;Development;Developmental Biology;Digit structure;Disease;Embryo;Embryonic Development;Engineering;Enzymes;Extracellular Matrix;fetal;Gene Modified;Genes;Germ Cells;growth differentiation factor 5;Growth Factor;HAS2 gene;Homeostasis;Hyaluronan;Hyaluronic Acid;Hyaluronidase;Immobilization;Impairment;In Situ Hybridization;In Vitro;Individual;Inflammatory;infrared spectroscopy;Injections;insight;Integral Membrane Protein;Joint by Site;joint formation;joint function;Joints;Knee;Knee joint;Lead;Ligaments;Limb structure;Link;Liquid substance;LoxP-flanked allele;Lubricants;lubricin;Maintenance;MAP2K1 gene;Mentored Research Scientist Development Award;Mentors;Mesenchymal;Metabolism;Molecular;Molecular Biology;Molecular Genetics;Molecular Weight;morphogens;Morphology;Motion;mouse model;Movement;Mus;mutant;novel;novel therapeutics;Pathway interactions;Phenotype;physical separation;Platelet-Derived Growth Factor beta Receptor;Play;Process;Property;prospective;protective pathway;Quality of life;rational design;receptor;Recombinants;repaired;Research;response;Role;Shapes;Shoulder;Signal Pathway;Signal Transduction;Site;skeletal;skills;Spectroscopy, Fourier Transform Infrared;stem cell function;Stress Fibers;Structure;sugar;Surface;Synovial Fluid;Synovial joint;System;Testing;Therapeutic;therapy design;Time;Tissues;Toll-like receptors;tool;Training;trait;transcriptome sequencing

PROJECT_TITLE: Cellular and molecular mechanisms regulating synovial joint development

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

ORG_STATE: CA

PHR: PROJECT NARRATIVE The goal of this research is to identify neurobehavioral makers of cigarette smoking initiation and tobacco use escalation among users of Electronic Nicotine Delivery Systems (ENDS). Findings are expected to advance mechanistic understanding, more accurate prediction, and more effective prevention of the typical escalation in tobacco products use among vulnerable YA ENDS users, including a five-fold risk of transition to cigarette smoking. Results are also expected to inform regulatory policy on ENDS, particularly flavored ENDS products, and to improve YA responsiveness to public health campaign communications.

PI_NAMEs: LIU, JIAYING  (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: abuse liability;addiction;Address;Adult;aerosolized;Awareness;Back;Behavior;Behavior assessment;Behavioral;Brain;career development;cigarette smoke;cigarette smoking;cognitive control;Communication;Competence;Cotinine;craving;Crossover Design;cue reactivity;Cues;Data;Dependence;design;Desire for food;Development;efficacy evaluation;Electronic Mail;Electronic Nicotine Delivery Systems;Emotions;Epidemic;Evaluation;executive function;Exhalation;experience;Food;Functional Magnetic Resonance Imaging;Goals;Grant;Health Campaign;high risk population;improved;incentive salience;indexing;Intervention;Link;Liquid substance;Maintenance;Marketing;Measures;Mediating;Nature;negative affect;neural;neurobehavioral;Neurocognitive;neuroimaging;Neurosciences;Neurosciences Research;never smoking;Nicotine;Nicotine Dependence;nicotine use;non-smoking;novel;Outcome;outcome prediction;Participant;Patient Self-Report;Persons;Policies;predictive marker;Predisposition;Prevention;primary outcome;Process;Psychological reinforcement;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;Regulation;Reporting;Research;Research Personnel;research study;Research Training;resilience;response;Rewards;Risk;Risk Assessment;Risk Factors;Risk Marker;risk prediction;Safety;Services;Severities;Smoke;Smoker;Smoking;smoking initiation;Stimulus;substance use;success;Surveys;System;Testing;timeline;Tobacco;tobacco control;tobacco prevention;tobacco products;tobacco regulatory science;Tobacco use;Training;Translating;Urine;vaper;vaping;Visit;Visual;Vulnerable Populations;Writing;young adult

PROJECT_TITLE: Neuroimaging approaches to improve prediction of smoking initiation and nicotine use escalation among young adult electronic nicotine delivery systems users


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Overall Project Narrative Recent technological advances in neuroscience have presented new approaches for vision researchers, in addition to challenges in terms of available access and expertise. The Harvard Vision Core plays a central role in vision research in the Harvard community by providing services, equipment, and training to over 20 vision research laboratories. The Core also brings vision scientists together by providing a collaborative environment for research and for training the next generation of vision scientists, and, in this way, the Vision Core at Harvard Medical School accelerates the pace of our understanding and treatment of dysfunctions of the visual system.

PI_NAMEs: LIVINGSTONE, MARGARET S (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TITLE: CORE GRANT FOR VISION RESEARCH


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PROJECT_TERMS: Address;Administrator;Advisory Committees;Basic Science;Boston;Collaborations;Communication;Communities;Core Grant;Ensure;experience;fabrication;Funding;Future;Glues;Goals;Grant;Individual;Institution;instrumentation;Laboratories;medical schools;meetings;operation;Pediatric Hospitals;Performance;Principal Investigator;Productivity;programs;Recording of previous events;Reporting;Research Personnel;Resources;Scientist;Services;Structure;success;support network;technology development;Time;Translational Research;Universities;Viral;Vision;Vision research;vision science

PROJECT_TITLE: Administrative Module


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project narrative The normal cell of origin (COO) from which a tumor arises is central to the treatment of blood cancers but does not factor into the standard of care for lung adenocarcinoma, a leading cause of world cancer death. We will explore a novel approach to map COOs in lung cancer, where COOs are not precisely known, by using the patterns of passenger mutations in their genome. This work may provide a new way to identify COOs for individual tumor samples and build a much needed bridge between human lung cancer biology and mouse models of this disease.

PI_NAMEs: IMIELINSKI, MARCIN  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Address;Affect;Alleles;Alveolar;alveolar type II cell;Atlases;Basal Cell;Benign;benign state;blood treatment;Cancer Biology;cancer cell;Cancer Etiology;cancer subtypes;cancer type;Carcinoma;cell type;Cells;Cessation of life;Chromatin;Classification;Clinical;clinically significant;cohort;Data;Development;disease model;Disseminated Malignant Neoplasm;Distal;DNA sequencing;driver mutation;Epigenetic Process;Epithelium;Event;Gene Expression Profile;Gene Proteins;Genetic;Genetic Transcription;Genetically Engineered Mouse;Genome;genome sequencing;genome-wide;Genomics;Genotype;Goblet Cells;Hematologic Neoplasms;Hematopoietic Neoplasms;Histologic;Histology;Human;Individual;insertion/deletion mutation;insight;Knowledge;Link;Lung;Lung Adenocarcinoma;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Mediating;Modeling;Morphology;mouse model;mutant;Mutation;mutational status;Neuroendocrine Cell;never smoker;Normal Cell;novel;novel strategies;Outcome;Patients;Pattern;Pharmaceutical Preparations;Prognosis;Research;response;Sampling;Signal Transduction;single cell ATAC-seq;single cell sequencing;Single Nucleotide Polymorphism;single-cell RNA sequencing;Somatic Mutation;Sorting;standard of care;STK11 gene;Stress;Study models;surfactant;targeted sequencing;Tattooing;Testing;Therapeutic;Tissues;tumor;Tumor Biology;tumor progression;Untranslated RNA;whole genome;Woman;Work

PROJECT_TITLE: Cell-of-Origin Footprints of Passenger Mutations in Human Lung Cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Bioengineering;Data Science;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: KREIMAN, GABRIEL  (contact)

PROJECT_TERMS: Acceleration;algorithm development;Area;Brain;cluster computing;Code;Communities;Computer Models;Computer Vision Systems;Core Grant;Dedications;Development;Educational workshop;Ensure;Face;Feedback;Funding;High Performance Computing;Infrastructure;interest;Machine Learning;machine learning model;Methods;model development;Modeling;Neurosciences;Neurosciences Research;next generation;pragmatic implementation;Process;Programming Languages;programs;repository;Research;Research Personnel;Resources;Source;Specialist;Testing;theories;tool;Training;Training and Education;Vision;Vision research;vision science;Visual Fields;visual neuroscience;Visual Perception;visual stimulus

PROJECT_TITLE: Computational Module


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

PROJECT_TITLE: Neuroengineering and Fabrication Module


PI_NAMEs: HE, ZHIGANG  (contact)

PROJECT_TERMS: Brain;Communities;Core Grant;Custom;design;Electrophysiology (science);experience;gain of function;Generations;Genetic;genetic manipulation;Goals;Image;Laboratories;loss of function;Maintenance;Maps;Methods;Modification;Molecular;Molecular Biology;neural circuit;Neurosciences;Neurosciences Research;optogenetics;Primates;Productivity;repository;Research Personnel;Resources;Retina;Rodent;Services;Standardization;Technology;Time;tool;vector;Viral;Viral Vector;Virus;Vision;Vision research;Visual System;Work

PROJECT_TITLE: Viral Module


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;HIV/AIDS;Infectious Diseases;Liver Disease;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Liver disease is a top cause of morbidity and mortality in people living with HIV, with emerging data indicating high risk for non-alcoholic fatty liver disease (NAFLD) development. The goal of this proposal is to develop a novel artificial intelligence-based approach for rapid and high-quality clinical chemical exchange saturation transfer (CEST), a molecular MRI technique used to assess metabolic brain dysfunction. CEST imaging as well as other MRI metrics of neuroinflammation, and their associations with blood markers and cognitive performance will help us to better understand and monitor potential interventions.

PI_NAMEs: UDDIN, MD NASIR  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, KHOA DINH DANG

PROJECT_TERMS: Acceleration;Affect;antiretroviral therapy;Artificial Intelligence;Biological Markers;biomarker performance;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood-brain barrier permeabilization;Brain;Brain Diseases;brain dysfunction;brain health;Brain Injuries;Chemicals;Clinical;Cognitive;cognitive function;cognitive performance;Data;deep learning model;deep neural network;Development;Diabetes Mellitus;Disease;Disease Progression;Functional disorder;Goals;gut microbiome;Health;high risk;HIV;HIV Infections;HIV Seropositivity;Hyperlipidemia;Hypertension;Image;Individual;Intervention;Knowledge;Life;Liver;Liver diseases;Magnetic Resonance Imaging;Measures;Mediating;Metabolic;Metabolic dysfunction;Metabolic syndrome;Methods;Microcirculation;Molecular;Monitor;Morbidity - disease rate;mortality;multimodality;neuroimaging;neuroinflammation;non-alcoholic fatty liver disease;novel;Older Population;Pathology;Persons;Population;Process;reconstruction;Research;Risk Factors;Techniques;Testing

PROJECT_TITLE: Impact of NAFLD on Metabolic Brain Function via CEST MRI in HIV-Positive Individuals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-P (55)]


NIH_SPENDING_CATS: Hematology;Kidney Disease

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE Innovative and transformational training schemes that motivate the next generation of scientists are needed to increase the numbers of highly trained PhD investigators and MD physician-researchers in kidney, urology, or non-malignant hematology (KUH) research. The University of Alabama at Birmingham KUH Undergraduate Research Experience (UAB KURE) program builds confidence and understanding in hands-on research skills and knowledge of physiological systems as well as enhances critical thinking, communication, and leadership skills in a thriving KUH research environment at UAB. The mission of the UAB KURE program is to inspire, motivate, and develop future KUH researchers from diverse backgrounds (racial/ethnic, rural/urban hometowns, scientific experience, undergraduate institutions) through an immersive short-term KUH research and professional development experiences.

PI_NAMEs: POLLOCK, JENNIFER S (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Academy;Address;Alabama;Area;Biomedical Research;Breathing;career;career development;career networking;Clinical;cohort;Communication;Communities;Critical Thinking;Development;disability;disadvantaged background;Doctor of Philosophy;Education Projects;Educational workshop;Environment;Ethnic Origin;Evaluation;experience;Exposure to;Faculty;faculty mentor;Feedback;Focus Groups;Foundations;Functional disorder;Future;graduate school;graduate student;hands on research;Hematology;Influentials;innovation;insight;Institution;interest;Kidney;Knowledge;Leadership;medical schools;Mentors;Mentorship;Mission;next generation;Non-Malignant;peer;peer coaching;Personal Satisfaction;Physicians;Physiological;Physiology;Postdoctoral Fellow;programs;Race;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Training;role model;Rural;Scheme;Scientist;skills;summer research;Surveys;System;Training;Training Programs;undergraduate research experience;undergraduate student;Universities;Urology;Woman

PROJECT_TITLE: UAB KUH KURE

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

ORG_STATE: IL

PHR: Veterans with cancer are at high risk of developing both cachexia, a muscle wasting disorder due to chronic disease, and age-related sarcopenia. However, current tools for diagnosing muscle wasting are inadequate or have not been thoroughly tested in the cancer population. In this study, we will determine the utility of D3- Creatine, an emerging biomarker of muscle wasting, using pre-clinical models of cancer and aging.

PI_NAMEs: LIEBER, RICHARD L. (contact)

PROJECT_TERMS: Address;Affect;Age;age related;age related chronic disease;aged;Aging;Analysis of Variance;animal old age;Animals;Area;Biological Assay;Biological Markers;Body Composition;Body mass index;Body Weight;Cachexia;cancer biomarkers;Cancer Cachexia;cancer clinical trial;Cancer Model;Cancer Patient;cancer therapy;Chronic Disease;Classification;Clinical;Clinical Research;Clinical Trials;cofactor;cognitive function;Creatine;Data;design;Development;Diagnosis;disability;Dryness;Euthanasia;Fatigue;Flexor;Functional disorder;functional outcomes;Future;Gait speed;Goals;Grant;hamstring;Hand Strength;Health;high risk;Hour;human disease;Image;imaging modality;Imaging Techniques;Implant;implantation;Individual;Inflammation;Intraperitoneal Injections;Label;lean body mass;Limb structure;liquid chromatography mass spectrometry;Lower Extremity;malignant muscle neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;mature animal;Measures;Methods;Modeling;Monitor;Morbidity - disease rate;mouse model;Mus;Muscle;muscle form;Muscle function;Muscular Atrophy;new technology;novel;novel marker;old mice;Outcome Measure;Pathologic;Pathology;patient population;Patients;Phenotype;Physical Function;Physical Performance;physically handicapped;Physiological;Population;pre-clinical;Pre-Clinical Model;preclinical study;Predisposition;Property;quadriceps muscle;Rehabilitation therapy;response;sarcopenia;Sepsis;Skeletal Muscle;Specificity;Techniques;Testing;Time;tool;treadmill;treatment risk;Urine;Veterans;Wasting Syndrome;Weight;Work;X-Ray Computed Tomography

PROJECT_TITLE: Pre-clinical study for the use of D3-Creatine as a biomarker in cachexia clinical trials

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Rehabilitation

ORG_CITY: SUFFOLK

ORG_NAME: NASONI LLC

ORG_STATE: VA

PHR: The Direct to Phase II SBIR goal is to optimize, validate, and commercialize Active-H2O, a sensor driven smart faucet to empower independent living for individuals impacted by Alzheimer’s disease (AD) and dementia. While dementia impacts many activities of daily living (ADLs), many key ADL’s require water access including hydration, bathing, grooming, & medication management. Therefore, commercialization of a smart faucet, to remind users of tasks & automatically deliver water in target temperature, force, & nozzle setting for specific ADLs, will empower individuals impacted by AD to age in place, while reducing caregiver burden & costs.

PI_NAMEs: OKHRAVI, HAMID REZA;WADDELL, JOHN STEVEN (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Activities of Daily Living;Adherence;Admission activity;Affect;Aging;aging in place;Algorithms;Alzheimer's Disease;Architecture;Bathing;Brain Diseases;Calibration;care costs;Caregiver Burden;Caregivers;case control;Clinic;Cognitive;commercialization;Computer software;Computer Vision Systems;cooking;cost;cost effective;Dementia;design;Devices;Digital Computers;digital ecosystem;Disease;drinking;efficacy study;Emergency department visit;empowerment;Environment;Foundations;Goals;Grooming;Hair;Health care facility;Height;Home;hospital readmission;Hospitalization;Household;Hydration status;improved;Incidence;Independent Living;Individual;innovation;intelligent algorithm;Intention;Intuition;Location;manufacture;manufacturing run;Medication Management;Memory Loss;Methods;Monitor;Motivation;Motor Skills;Nursing Homes;older adult;Performance;Persons;Pharmaceutical Preparations;Phase;Positioning Attribute;preference;pressure;Procedures;Production;prototype;reconstruction;Risk Factors;sensor;Serious Adverse Event;Small Business Innovation Research Grant;Software Validation;Spinal cord injury;success;support tools;Symptoms;System;Technology;Temperature;Testing;Update;usability;Water

PROJECT_TITLE: Active-H2O: Sensor driven smart faucet to empower independent living for individuals impacted by Alzheimers disease and dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-C (10)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Chronic Pain;Emerging Infectious Diseases;Infectious Diseases;Pain Research;Wound Healing and Care

ORG_CITY: Watertown

ORG_NAME: IONIC PHARMACEUTICALS

PHR: NARRATIVE Bacterial infection of burn wounds is common and increases both the morbidity and mortality of burn injuries. Furthermore, current burn dressings adhere to the wound surface and make each change of dressing excruci- atingly painful for the patient as well as cumbersome and time consuming for clinical personnel. This proposal develops a novel treatment that addresses difficult to treat infections (e.g., methicillin-resistant Staphylococcus aureus) wherein a new drug that prevents bacteria from communicating and coordinating attacks against the host/patient is delivered via a novel wound dressing that alleviates patient pain during dressing changes.

PI_NAMEs: COLBY, AARON HENRY (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: absorption;Address;Adjuvant;Amines;Analgesics;Animals;Antibiotics;aqueous;Autopsy;Bacitracin;Bacteria;Bacterial Infections;bacterial resistance;beta-Lactams;Burn injury;burn model;burn wound;Caregivers;Cephalosporins;Characteristics;Clinical;clinically relevant;combat;Communication;comparison control;Complex;Consumption;Critical Pathways;Crosslinker;Debridement;Dendrimers;density;Development;Drug resistance;efficacy evaluation;Elasticity;Elbow;Excipients;Exposure to;Exudate;fighting;flexibility;foot;Formulation;Future;Gel;hamstring;Hand;Human Resources;Hydrogel Bandage;Hydrogels;immune clearance;Immune response;Immune system;improved;In Situ;In Vitro;in vitro activity;in vivo;Infection;infection management;inhibitor;intercellular communication;Intractable Pain;Invaded;Investigation;Joints;large scale production;Life;Linezolid;Link;manufacture;Mechanics;methicillin resistant Staphylococcus aureus;methicillin susceptible Staphylococcus aureus;Morbidity - disease rate;mortality;Movement;Mus;Natural Products;Nature;novel;novel therapeutics;Opioid;opportunistic pathogen;Pain;Pain management;Painless;pathogen;Pathway interactions;Patients;Penicillins;Pharmaceutical Preparations;Pharmacologic Substance;Phase;phase 1 study;preclinical study;prevent;Production;prophylactic;prospective;prototype;psychologic;quorum sensing;Rattus;Reaction;Regimen;Regulator Genes;second degree burn;secondary metabolite;Signal Transduction;Small Business Innovation Research Grant;standard of care;Staphylococcus aureus;Staphylococcus aureus infection;Staphylococcus epidermidis;Sterile coverings;success;Sulfhydryl Compounds;Surface;Technology;technology development;Testing;Therapeutic;thioester;Time;Topical application;Toxin;Trauma patient;Vancomycin;Virulence;Virulence Factors;wound;wound dressing;wound healing;Wound Infection

PROJECT_TITLE: Treating Second-Degree Burn Wound Infections with a Quorum Sensing Inhibitor

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-F (12)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Emphysema;Genetics;Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Chronic obstructive pulmonary disease (COPD) is a prevalent and progressive obstructive lung disease caused by cigarette smoke exposure with few effective therapies. The role of mitochondrial dysfunction and cellular senescence, a state of cell arrest, in COPD pathogenesis remain unknown and an area of high scientific interest. The work under this Diversity supplement and R01 will define how adenine nucleotide translocase (ANT2), a mitochondrial ADP/ATP translocase, influences mitochondrial dysfunction that drives cellular senescence and abnormal repair of the lung epithelium, thus opening the potential for ANT as a therapeutic target for COPD.

PI_NAMEs: KLIMENT, CORRINE R (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Adenine Nucleotide Translocase;Affect;Air Pollution;airway obstruction;Alveolar;alveolar destruction;alveolar epithelium;Antioxidants;Area;Automobile Driving;bronchial epithelium;Cause of Death;Cell Aging;Cell Cycle Arrest;Cell Death;Cell Line;Cell Physiology;Cells;Cellular Metabolic Process;Chronic;Chronic Obstructive Pulmonary Disease;cigarette smoke;Data;Development;Disease;Disease Progression;DNA Damage;Doctor of Philosophy;effective therapy;Epithelial Cells;epithelial repair;Equilibrium;Excision;exposure to cigarette smoke;gain of function;Gene Expression;Genetic;Genus Hippocampus;Homeostasis;Human;improved;In Vitro;in vivo;in vivo Model;Individual;Inflammation;inhibitor;Injury;insight;interest;knock-down;Knock-out;Knockout Mice;Knowledge;Link;loss of function;Lung;Lung Diseases;lung injury;lung repair;Mediating;Metabolic;Metabolism;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;mouse model;Mus;NADH;novel;novel therapeutic intervention;Obstructive Lung Diseases;oncoprotein p21;Organoids;Oxidation-Reduction;parent project;Parents;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;prevent;Production;progenitor;programs;Proliferating;Pulmonary Emphysema;Reactive Oxygen Species;repaired;Research;Research Project Grants;Respiration;response;restoration;Risk Factors;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Slice;Smoking;stem cell function;stem cells;Structure of parenchyma of lung;Testing;Therapeutic;therapeutic target;therapy development;Tissues;Transcriptional Regulation;United States;Work

PROJECT_TITLE: The Role of Adenine Nucleotide Translocase in Mitochondrial Dysfunction Associated Senescence in Chronic Obstructive Pulmonary Disease (COPD)


NIH_SPENDING_CATS: Kidney Disease

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Lay Summary The current proposal seeks to fund 14 undergraduate students annually to work with Mayo Clinic researchers in Nephrology or Urology. This 10-week summer program will pair undergraduates with Mayo Clinic researchers to carry out specific research projects. Students will participate in a research training course, take a cell and renal mini-course, organize their lab data into abstracts, oral research presentations and poster presentations. Talks will be given to Mayo faculty and posters will be presented at the NIDDK-KUH Summer Research Symposium held annually at the end of the Summer. In the past 10 years, >75% of students received professional degrees, 25 federal grants were received and ~10% of students have entered Nephrology or Urology-related fields.

PI_NAMEs: ROMERO, MICHAEL F. (contact)

PROJECT_TERMS: American;Applied Research;Area;Award;Basic Science;Biomedical Research;career;Cells;Clinic;Clinical;Clinical Medicine;clinical training;college;Crystallization;Data;Development;Doctor of Philosophy;Education;education research;effectiveness evaluation;Enrollment;Environment;Exclusion;experience;Exposure to;Faculty;Fellowship;Fellowship Program;Female;Fostering;Foundations;Fruit;Funding;Future;Goals;graduate school;graduate student;Grant;Health;Home;innovation;Instruction;interest;Internal Medicine;Intervention;Kidney;Kidney Calculi;Laboratories;Laboratory Research;Medical;Medical Students;Medicine;Mentors;Minority;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;Oral;Paper;Peer Review;Plants;Polycystic Kidney Diseases;Postdoctoral Fellow;posters;Predisposition;programs;Qualifying;radiologist;Recording of previous events;Research;Research Personnel;Research Project Grants;Research Training;Residencies;response;Science;Scientist;Societies;Students;summer program;summer research;symposium;Talents;Time;Training;Training Programs;Translational Research;undergraduate research;undergraduate student;United States National Institutes of Health;urologic;Urology;Woman;Work

PROJECT_TITLE: Mayo Clinic Nephrology & Urology Summer Undergraduate Research Fellowship (nuSURF)

STUDY_SECTION_NAME: Fellowships in Kidney, Urology, and Hematology[DDK-G]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Estrogen;Genetics;Physical Injury - Accidents and Adverse Effects;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative This application to RFA-AI-23-024 (Sex-Difference in Radiation Research) will evaluate if sex-based differences in the regulation of renin-angiotensin enzyme ACE2 contribute to observed sex-differences in radiation sensitivity to gastrointestinal (GI) injury. We hypothesize ACE2 activity within the intestinal endothelium protects against radiation induced GI damage by increasing Ang1-7 signaling through MasR. The three Aims are designed to interrogate the role of biological sex in this pathway using a combination of novel pharmacologic, genetic, and imaging tools.

PI_NAMEs: HIMBURG, HEATHER A (contact)

PROGRAM_OFFICER_NAME: TALIAFERRO, LANYN P

PROJECT_TERMS: Acceleration;ACE2;Acute;Adult;Age;Agonist;angiotensin I (1-7);Angiotensin II;Angiotensins;Animal Model;Anti-Inflammatory Agents;Binding;Biological;biological sex;blood pressure reduction;Bone Marrow;cadherin 5;Childhood;Citrulline;Data;design;Development;dosage;Endothelial Cells;Endothelium;Enterocytes;Enzyme Activation;Enzymes;Estrogens;FDA approved;Female;fluorescence imaging;G-Protein-Coupled Receptors;gain of function;gastrointestinal;Gastrointestinal Injury;gastrointestinal system;Genes;Genetic;Genetic Transcription;Goals;Gonadal Steroid Hormones;Hematopoietic;Histopathology;Hormones;imaging approach;Imaging Device;improved;in vivo;inducible Cre;intestinal barrier;intestinal epithelium;Intestines;irradiation;Kidney;Laboratories;Link;Location;loss of function;Lung;male;Mediating;medical countermeasure;Membrane;Messenger RNA;Modeling;Morbidity - disease rate;mouse model;Mus;Normal tissue morphology;novel;Ovariectomy;Pathogenesis;Pathway interactions;Peptides;Peptidyl-Dipeptidase A;pharmacologic;Predisposition;Production;Proteins;Radiation;Radiation Dose Unit;Radiation exposure;Radiation Injuries;radiation response;Radiation Tolerance;Radiation Toxicity;Radiobiology;Rattus;receptor;Recovery;Regulation;Renin;Reporting;Research;response;Rodent Model;Role;secondary endpoint;Serum;Severities;sex;Sex Differences;Signal Transduction;Site;small molecule;Source;Tissues;Toxic effect;Transcript;Vasoconstrictor Agents;villin;women versus men;women's treatment;Work;X Chromosome;X Inactivation

PROJECT_TITLE: Sex-differences in ACE2 Regulate Normal Tissue Toxicity During Gastrointestinal Acute Radiation Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 MR-I (M1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases

ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

ORG_STATE: MD

PHR: Project Narrative The FASEB Virus Structure and Assembly Conference is a one-of-a-kind event that attracts scientists worldwide to showcase the latest research data on virus structure, assembly, and function, including biomedical and nanotechnological applications of viruses. The Conference is highly interactive, inclusive, and training-focused, encouraging communication and cross-disciplinary cooperation and promoting exchange and interaction between senior- and early-stage researchers and graduate students. A focus on RNA virus pathogens such as HIV-1, SARS-CoV-2, and Influenza characterizes the 2024 FASEB Virus Structure and Assembly Conference that will be held in Southbridge, MA.

PI_NAMEs: CINGOLANI, GINO  (contact)

PROGRAM_OFFICER_NAME: GUTIERREZ, MARTIN

PROJECT_TERMS: 2019-nCoV;Academia;Active Learning;Anti-viral Response;Archaeal Viruses;Area;Award;Awareness;Bacteriophages;base;Biological;Biology;Biomedical Technology;biophysical analysis;career;Career Choice;career development;Cells;Collaborations;Communication;comparative;Complement;Cryoelectron Microscopy;Data;Dedications;Defense Mechanisms;design;Discipline;Doctor of Philosophy;Educational process of instructing;Educational workshop;Ensure;Event;Evolution;Exposure to;Family;Financial Support;Funding;Future;Gender;genetic pedigree;Genome;Goals;Government;Government Agencies;graduate student;Grant;Herpesviridae;HIV;HIV-1;Industry;Infection;Influenza;innovation;interdisciplinary approach;International;Laboratories;Learning;Life Cycle Stages;macromolecule;Medical;meetings;Mentors;Methodology;Nanotechnology;Oral;pandemic preparedness;Participant;pathogenic virus;Pathogenicity;Pathway interactions;Postdoctoral Fellow;posters;Private Sector;programs;Race;Research;Research Personnel;RNA Viruses;Running;Scholarship;Science;Scientist;Series;Sorting;Structural Biologist;Structure;Students;success;symposium;System;Technology Transfer;Textbooks;Therapeutic;tool;Training;Travel;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Vaccines;Viral;viral genomics;virology;Virus;Virus Assembly;virus classification;virus host interaction;virus infection mechanism;Virus Replication;Woman;Women's Group

PROJECT_TITLE: Virus Structure and Assembly

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LK-D (J1)]


ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Sex differences are present in glioblastoma (GBM), with males presenting with GBM more frequently than females and with a more aggressive disease. Many mouse models recapitulate these sex differences and have been leveraged for key observations of how the immune response contributes to GBM sex bias; however, many of these mouse models do not reflect key mutations observed in the human condition, and tumor models are often devoid of a complete set of sex chromosomes. The objective of this revision application is to integrate a more representative mouse model generated through the NCI IMAT Program into an ongoing P01 on sex differences in brain tumors with the goal of assessing the interaction between the immune response and changes in the tumor microenvironment using models that contain human mutations and intact sex chromosomes.

PI_NAMEs: LATHIA, JUSTIN D. (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Affect;Applications Grants;Attenuated;Benchmarking;Biological Models;Biological Process;biological sex;Brain;brain cell;Brain Neoplasms;Carcinogens;Cells;Cytology;Disease;Disease Progression;Electroporation;Elements;empowerment;Epidermal Growth Factor;Epidermal Growth Factor Receptor;epidermal growth factor receptor VIII;Epigenetic Process;exhaust;experience;Experimental Models;Female;fitness;Four Core Genotypes;Future;gain of function mutation;Generations;Genetic;Genetic Engineering;genome editing;Glioblastoma;Glioma;Gliomagenesis;Goals;Histology;host neoplasm interaction;Human;human disease;Human Genetics;human model;Immune;immune cell infiltrate;Immune response;Immunocompetent;in vivo;Infiltration;Iron;junctional adhesion molecule;Knock-out;Laboratory Animals;LCN2 gene;Left;male;Malignant neoplasm of brain;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant neoplasm of testis;Malignant Neoplasms;men;Methods;Microglia;Modeling;Molecular Abnormality;Molecular Target;monocyte;mosaic analysis;mouse model;Mus;Mutation;Myeloid-derived suppressor cells;Neonatal;neoplastic cell;Neurons;NF1 gene;Oncogenes;Oncogenic;parent project;Pathologic;Phenocopy;plasmid DNA;Population;Primary Cell Cultures;Prognosis;Program Research Project Grants;programs;recombinase;reproductive;Research Design;Sampling;sex;Sex Bias;Sex Chromosomes;Sex Differences;Signal Transduction;standard of care;T-Lymphocyte;Technology;Testing;TP53 gene;Transgenic Animals;Transplantation;tumor;Tumor Cell Invasion;tumor growth;tumor microenvironment;Tumor Suppressor Proteins;tumor-immune system interactions;uptake;Uterine Cancer;Variant;Wild Type Mouse;Woman;women versus men

PROJECT_TITLE: Incorporation of the Four Core Genotype Transgenic Animal and a Newly Developed EGFRvIII-Based GBM Model into the existing Program Project Grant on Sex-Based Differences in Glioma

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-D (M2)]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE  Sex differences are present in glioblastoma (GBM), with males presenting with GBM more frequently than  females and with a more aggressive disease. Many mouse models recapitulate these sex differences and have  been leveraged for key observations of how the immune response contributes to GBM sex bias; however, many  of these mouse models do not reflect key mutations observed in the human condition, and tumor models are  often devoid of a complete set of sex chromosomes. The objective of this revision application is to integrate a  more representative mouse model generated through the NCI IMAT Program into an ongoing P01 on sex  differences in brain tumors with the goal of assessing the interaction between the immune response and changes  in the tumor microenvironment using models that contain human mutations and intact sex chromosomes.

PI_NAMEs: SILVER, DANIEL J (contact)

PROJECT_TERMS: Affect;asexual;Astrocytes;Benchmarking;Biological;Biological Models;Biological Process;biological sex;Brain;brain cell;Brain Neoplasms;Cancer Model;Carcinogens;Cell Culture Techniques;cell type;Cells;chemical carcinogenesis;Cytology;Data;Development;Disease;Disease Progression;Electroporation;Epidermal Growth Factor;Epidermal Growth Factor Receptor;epidermal growth factor receptor VIII;Epigenetic Process;exhaust;experience;Experimental Models;Female;fitness;Four Core Genotypes;Future;gain of function mutation;Genetic;Genetic Engineering;genome editing;Glioblastoma;Glioma;Goals;Growth;Histology;Human;human disease;Human Genetics;Immune;immune cell infiltrate;Immune response;Immune system;Immunocompetent;in vivo;Infiltration;junctional adhesion molecule;Laboratory Animals;Left;male;Malignant - descriptor;Malignant neoplasm of brain;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant neoplasm of testis;Malignant Neoplasms;men;Microglia;Modeling;Molecular Abnormality;Molecular Target;monocyte;mosaic analysis;mouse model;multiple omics;Mus;Mutation;Myeloid-derived suppressor cells;neoplastic cell;Neurons;NF1 gene;Oncogenes;Oncogenic;parenting intervention;Pathologic;Phenocopy;plasmid DNA;Population;Process;Prognosis;Program Research Project Grants;programs;recombinase;reproductive;Resolution;Sampling;Serum;sex;Sex Bias;Sex Chromosomes;Sex Differences;Shapes;Signal Transduction;Specific qualifier value;standard of care;T-Lymphocyte;Technology;TP53 gene;Transgenic Animals;Transplantation;tumor;tumor microenvironment;Tumor Suppressor Proteins;tumor-immune system interactions;Uterine Cancer;Variant;Wild Type Mouse;Woman

PROJECT_TITLE: Sex-specific differences in the tumor microenvironment alter glioblastoma growth


ORG_CITY: SCOTTSDALE

ORG_NAME: VITALANT

ORG_STATE: AZ

PHR: Project Narrative As HIV-infected individuals age, they experience non-AIDS, inflammation-related illnesses, such as cardiovascular disease (CVD), even when the virus is suppressed with antiretroviral therapy. This proposal will yield novel integrated and innovative approaches in the emerging field of extracellular vesicles (EVs) and HIV- associated atherosclerosis to reveal a novel measure of immune/inflammatory responses for discovering potential predictor biomarkers and will make unique contributions to the deeper understanding of how EVs and their cargo impact the resolution of inflammation to influence CVD risk in HIV in a mechanistic manner. The idea is that, if extracellular vesicles are altered, then by understanding exactly how they are altered, we will lay the groundwork for developing novel therapeutic strategies to reduce HIV-associated chronic inflammation, and lifelong co-morbidities.

PI_NAMEs: MARQUES DE MENEZES, ERIKA GRASIELA (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Acceleration;Adult;Affect;Age;angiogenesis;antiretroviral therapy;Apolipoprotein E;Apoptosis;Atherosclerosis;Biological Markers;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Carotid Arteries;CASP1 gene;Caspase Inhibitor;causal variant;Cell Death;Cell Physiology;Cells;Chronic;cohort;comorbidity;comparison control;CRISPR screen;Data;Development;Disease;DNA;Endothelial Cells;Epigenetic Process;exosome;experience;extracellular vesicles;Functional disorder;General Population;Genes;genome-wide;Heart Diseases;HIV;HIV Infections;HIV-1;Immune;immune activation;Immunologics;in vitro Model;Individual;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;innovation;Intervention;intimal medial thickening;Measures;Mediating;MicroRNAs;Molecular;mouse model;Mus;novel;novel therapeutic intervention;Pathway interactions;Persons;Play;predictive marker;prevent;Production;Resolution;risk prediction;RNA;Role;Sampling;Signal Transduction;systemic inflammatory response;Testing;therapeutic target;Virus

PROJECT_TITLE: Extracellular Vesicles as Biomarkers and Therapeutic Targets for Atherosclerotic Cardiovascular Disease in Persons Living with HIV


ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: Lung cancer kills more Veterans than any other cancer. Veterans are more likely than civilians to present with lung cancer that is unresectable and spread to the lymph nodes (Stage III). Immune checkpoint blockade can cure a subset of Veterans with locally advanced Stage III or metastatic Stage IV cancer. At present, the standard of care for Stage III NSCLC is six weeks of chemotherapy and radiation followed by one year of maintenance immune checkpoint blockade. This is challenging for many patients and may not be needed in all cases. We have found Veterans whose lung cancer expresses immune checkpoints most benefit from immune checkpoint blockade. In this clinical trial, we are trying to see if by using the immunotherapy upfront, overall tolerability of the three treatments can be improved. If this is true, we may be able to help more Veterans with lung cancer live longer lives with less treatment toxicity.

PI_NAMEs: RAMNATH, NITHYA  (contact)

PROJECT_TERMS: Adjuvant;American;arm;Benchmarking;chemoradiation;Chemotherapy and/or radiation;Clinical;Clinical Trials;cohort;Data;Diagnosis;Disease;Enrollment;fluorodeoxyglucose positron emission tomography;Future;Goals;immune checkpoint;immune checkpoint blockade;Immune response;Immuno-Chemotherapy;Immunologic Adjuvants;Immunophenotyping;Immunotherapy;improved;lung cancer screening;lymph nodes;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Melanoma;Metabolic;Modality;Modeling;Neoadjuvant Therapy;next generation sequencing;Nivolumab;Non-Small-Cell Lung Carcinoma;Oncology;open label;Outcome;participant enrollment;Pathologic;Patient-Focused Outcomes;Patients;Performance;PET/CT scan;Phase II Clinical Trials;Positioning Attribute;Positron-Emission Tomography;precision oncology;primary endpoint;prognostic;programmed cell death ligand 1;Progression-Free Survivals;Prospective Studies;Quality of life;Radiation;Radiation therapy;radiological imaging;Randomized;Rectal Cancer;Recurrence;Resectable;response;secondary endpoint;Secondary to;Site;Solid;standard of care;success;Testing;Tissue Sample;Tissues;Toxic effect;Treatment Factor;treatment strategy;Treatment-related toxicity;tumor DNA;Tumor Immunity;Tumor Markers;Unresectable;uptake;Veterans;War;Work

PROJECT_TITLE: Repositioning Immunotherapy in Veterans with Lung Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 SPLP-Y (01)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Immunization;Immunotherapy;Orphan Drug;Precision Medicine;Rare Diseases

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Narrative Cancer is a leading cause of death around the world. An immune-based, non-toxic approach that attacks the cancer as well as the supporting deficiencies that facilitate its progression would be a great boon to the field. This project aims to improve public health by developing a successful tumor immunology model, which can be applied to study immunological reactions to the immunotherapy and eliminate long-term cancer reappearance without disrupting normal immune function.

PI_NAMEs: KONRY, TANIA TALI (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: 3-Dimensional;Address;Affect;Animal Model;Animals;anti-tumor immune response;Appearance;Autologous;Behavior;Biological;Biological Assay;Biomedical Engineering;Biomimetics;Bispecific Antibodies;Bone Marrow;Cancer Biology;cancer cell;Cancer Patient;CAR T cell therapy;Cause of Death;Cell Communication;Cell Culture System;Cell Physiology;Cell Survival;Cell Therapy;Cells;Cellular biology;Cessation of life;Characteristics;chimeric antigen receptor T cells;Clinic;Clinical;clinical application;Clinical Trials;Collaborations;Complex;Development;Devices;Disease;Disease Progression;Disease Resistance;Drug Screening;efficacious treatment;Environment;Evaluation;Evolution;experience;Generations;Genetic Transcription;Goals;Hematologic Neoplasms;Human;Hypoxia;Immune;Immune Evasion;immune function;immune resistance;Immunocompromised Host;immunogenic;immunoreaction;Immunosuppression;Immunotherapy;improved;In Situ;In Vitro;in vitro Model;in vivo;Individual;individual patient;innovative technologies;Killer Cells;lymphoid organ;Maintenance;Malignant Neoplasms;Metabolism;Methods;Microfluidic Microchips;Microfluidics;microphysiology system;mimetics;Modeling;Molecular;Molecular Profiling;Monitor;multidisciplinary;Multiple Myeloma;Mus;Nature;neoplastic cell;new technology;normoxia;novel;optimal treatments;Oxygen;parallel processing;Pathway interactions;Patients;Perfusion;personalized medicine;Persons;Pharmaceutical Preparations;Phenotype;physical property;Physiological;Play;pre-clinical;precision medicine;Predisposition;pressure;Proliferating;Public Health;Recovery;Refractory;Relapse;Research;Research Personnel;Resistance;responders and non-responders;response;RNA;Role;scaffold;sensor;side effect;simulation;single-cell RNA sequencing;Solid;spatiotemporal;spheroids;Spleen;Structure;System;Technology;technology platform;Testing;Time;Tissue Engineering;transcriptomics;Treatment Efficacy;treatment strategy;tumor;tumor heterogeneity;tumor hypoxia;tumor immunology;tumor microenvironment;Validation;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Microphysiological platform for analyzing multiple myeloma's tumor microenvironment, enabling immunotherapy assessment and drug screening.

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-J (M1)]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PI_NAMEs: JEBELLI, HOUTAN  (contact)

PROJECT_TITLE: NIOSH Exploratory/Developmental Grant Program (R21)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Down Syndrome;Emerging Infectious Diseases;Immunization;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Lung;Pediatric;Prevention;Vaccine Related

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE: Individuals with Down syndrome are at increased risk of recurrent respiratory infections, including SARS-CoV- 2 infections. The implementation of non-pharmaceutical interventions (NPIs) such as hand washing, social distancing, and face masking during the pandemic has resulted a dramatic global reduction in the incidence of common respiratory virus infections. Through determining the burden of all-cause respiratory morbidity during the pandemic time, the proposed study will provide important information to inform the usage of subsequent vaccines, protection products, and therapeutic strategies to reduce respiratory morbidity in individuals with Down syndrome.

PI_NAMEs: WU, PINGSHENG  (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: 2019-nCoV;6 year old;Adaptive Immune System;Address;Administrative Supplement;Age;Anatomy;Antibody Response;Asthma;Award;Birth;Bronchiolitis;Bronchitis;Calendar;Cessation of life;Characteristics;Child;Chromosome 21;Clinical;Code;cohort;Complication;Congenital chromosomal disease;congenital heart abnormality;COVID-19;COVID-19 burden;COVID-19 impact;COVID-19 pandemic;COVID-19 severity;COVID-19 vaccination;Croup;Data;Deformity;Department of Defense;Down's Syndrome;Eligibility Determination;Enrollment;experience;Face;follow-up;Future;Goals;Handwashing;Healthcare;Healthcare Systems;Immunization;Immunologics;Incidence;Individual;Infant;Infection;Influenza;Infrastructure;Innate Immune System;Inpatients;interest;Intervention;Investigation;life span;Lung;Mechanical ventilation;Medicaid;Military Personnel;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;Organ;Otitis Media;Outpatients;Oxygen;pandemic disease;Parents;Persons;Pharmaceutical Preparations;Phenotype;Physiological;Pneumonia;population based;Predisposition;Prevalence;programs;Public Health;Recurrence;Reporting;Research;respiratory;Respiratory Failure;respiratory health;respiratory infection virus;respiratory morbidity;Respiratory syncytial virus;Respiratory Tract Infections;respiratory virus;Risk;Risk Factors;SARS-CoV-2 infection;severe COVID-19;Severities;Severity of illness;Sleep Apnea Syndromes;Social Distance;Subgroup;Tennessee;Therapeutic;Time;Tube;Tympanostomy;United States;Vaccination;Vaccines;Variant;Viral Respiratory Tract Infection;Virus;Visit;Wheezing;World Health Organization

PROJECT_TITLE: Respiratory morbidity during the pandemic time in individuals with Down syndrome

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging;Biotechnology;Immunotherapy;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: OWEGO

ORG_NAME: CELL PRESERVATION SERVICES, INC.

PHR: Currently many clinical trials use frozen NK cells for cell therapy to treat a variety of cancers. Unfortunately, however, the cryopreservation process results in a substantial loss of cell viability and function due to the activation of complex molecular based cell stress response to the freeze/thaw process. Further, today the far majority, if not all, cryopreservation processes rely on DMSO (a toxic and mutagenetic agent) as the primary cryoprotective agent. This Phase I project is designed to develop a unique cryoprotective agent cocktail for NK cells that doesn’t contain toxic compounds such as DMSO. Additionally, we will develop a unique post-thaw cell stress molecular modulation reagent designed to increase recovery of NK cells post-thaw regardless of the cryopreservation media utilized. A unique hypothesis to be tested is whether the delayed onset cell death that occurs following thawing is due (in part or whole) to accelerated stress-based cell aging triggered by the cryopreservation process. Together these technologies will yield enhanced NK cell survival thereby improving NK cell therapy outcome for patients worldwide.

PI_NAMEs: BAUST, JOHN M (contact)

PROGRAM_OFFICER_NAME: BILLINGSLEA, EDDIE

PROJECT_TERMS: Acceleration;Active Biological Transport;Age;age acceleration;aging process;aging related;Animal Model;Apoptosis;Apoptotic;Area;Attention;biobank;biological adaptation to stress;Biotechnology;cancer therapy;CAR T cell therapy;Caspase;cell age;Cell Aging;Cell Death;Cell membrane;Cell Membrane Permeability;Cell Physiology;Cell Survival;Cell Therapy;Cells;Cellular Stress;Chemicals;chimeric antigen receptor T cells;Clinic;Clinical;Clinical Trials;Complex;conditioning;Coupled;Cryopreservation;Cryopreserved Cell;Cryopreserved Tissue;Cryoprotective Agents;Crystallization;cytokine;cytotoxic;cytotoxicity;Dedications;design;Device or Instrument Development;Dimethyl Sulfoxide;Dose;Evaluation;experience;Formulation;Freezing;Future;Genes;Goals;Growth;Hepatocyte;Human;Human Resources;human stem cells;Ice;Immunotherapeutic agent;improved;in vivo;Inferior;Infusion procedures;Injury;innovation;Longevity;Malignant Neoplasms;Mesenchymal Stem Cells;Methods;Mitochondria;Molecular;mouse model;natural hypothermia;Natural Killer Cells;Necrosis;neoplastic cell;NK cell therapy;novel;novel strategies;Outcome;Patient-Focused Outcomes;Patients;Phase;phase 1 study;Poison;Population;premature;preservation;prevent;Process;Production;Proteins;Protocols documentation;Publications;Reagent;Recovery;Reporting;Research;response;Resveratrol;Science;Sirtuins;Sister;Somatic Cell;stem cells;Stress;sugar;Sugar Alcohols;symposium;Techniques;Technology;Testing;Therapeutic;Toxic effect;Transportation

PROJECT_TITLE: A Novel Multicomponent DMSO Free Cryococktail and Recovery Reagent for the Improved Cryopreservation of NK Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-G (15)]


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Nanotechnology;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: The overall goal of this proposal is to further advance the cutting-edge plasmonic EV sensing technology for multiplexed protein and RNA biomarker analysis in single EVs. Using longitudinal clinical samples collected during therapy, we will assess the clinical utilities of EV analyses for monitoring and evaluating treatment response in ovarian cancer.

PI_NAMEs: IM, HYUNGSOON  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Aftercare;Antibodies;Area;Benchmarking;Binding;biobank;Biological Assay;Biological Markers;Biological Models;Biology;biomarker panel;Blood;Body Fluids;cancer biomarkers;cancer cell;cancer diagnosis;cancer invasiveness;Cancer Patient;cancer therapy;candidate marker;Cell Line;Cells;chemotherapy;Clinical;clinical translation;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Cytolysis;Detection;detection platform;detection sensitivity;Drug resistance;Drug usage;Electromagnetic Fields;Epitopes;experimental study;extracellular vesicles;Genetic Materials;Goals;Human;improved;insight;Laboratories;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Membrane;Methods;Modality;Modeling;Molecular;Molecular Analysis;Molecular Probes;Molecular Profiling;Monitor;nano;nanodisk;nanoflow cytometry;nanoGold;nanoplasmonic;Nanostructures;Nucleic Acids;Organoids;Outcome;Paclitaxel;Patient Care;patient response;Patients;Performance;personalized cancer therapy;Pharmaceutical Preparations;Phenotype;Plasma;plasmonics;Prediction of Response to Therapy;Primary Neoplasm;Procedures;prospective;protein biomarkers;Proteins;Protocols documentation;Recurrence;Reproducibility;Research;response;RNA;RNA marker;Sampling;sensor;sensor technology;Signal Transduction;Specificity;Specimen;Standardization;success;Surface;System;Systems Integration;targeted treatment;Technology;Testing;Time;Treatment Efficacy;treatment response;tumor;Tumor-Derived;Urine;Validation;Vesicle

PROJECT_TITLE: Nano-CRISPR extracellular vesicle sensing system for longitudinal tumor monitoring


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Cost Effectiveness Research;HIV/AIDS;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: NARRATIVE Global progress to eliminate mother-to-child transmission of HIV (eMTCT) has stagnated in recent years, highlighting the need for a multifaceted approach that complements the existing focus on treatment initiation among pregnant women living with HIV. This project aims to use simulation-based modeling to evaluate the cost- effectiveness of a wide range of eMTCT interventions and identify optimal intervention portfolios tailored to Kenya, Nigeria, and Botswana, three diverse country contexts that will serve as highly translatable case studies for other African settings. Our findings from this comprehensive eMTCT intervention analysis will provide urgently needed support for eMTCT policymaking and pave the way for a new frontier in eMTCT progress.

PI_NAMEs: DUARTE, HORACIO ADRIAN (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Address;Adult;Africa South of the Sahara;African;antiretroviral therapy;Area;Botswana;Breast Feeding;Case Study;Characteristics;Child;Conceptions;Contraceptive methods;cost effectiveness;cost-effectiveness evaluation;Costs and Benefits;Country;demographics;Economics;Effectiveness;Ensure;Epidemic;Evaluation;frontier;Genetic Complementation Test;Guidelines;Health Policy;HIV;HIV Infections;infant infection;Infection;Intervention;Investments;Kenya;Mentors;Methods;models and simulation;Mother-to-child HIV transmission;Mothers;Nigeria;Play;Policies;Policy Making;Population;Postpartum Period;pre-exposure prophylaxis;Pregnancy;pregnant;Pregnant Women;prevent;Prevention strategy;programs;reproductive;Resources;Role;Science;Testing;Time;transmission process;treatment strategy;Vertical Disease Transmission;Viral;Viral Load result;Woman;Work

PROJECT_TITLE: Informing optimal investments along the preconception to postpartum eMTCT continuum


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Populations of sexual and gender minorities (SGM) are disproportionally impacted by higher rates of human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs). Effective biomedical prevention, such as same day preexposure prophylaxis (PrEP) and doxycycline postexposure prophylaxis (DoxyPEP), are effective strategies to reduce rates of both HIV and other STIs; however, their use in the primary care setting have not been widely explored. This study aims to leverage key stakeholder (e.g., SGM client and primary care clinicians) perspectives to identify factors influencing awareness, uptake, and persistence of same day PrEP and DoxyPEP in the primary care setting.

PI_NAMEs: ALBRIGHT, NATHANIEL  (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: Address;Affect;AIDS prevention;Awareness;career;Caring;Categories;Client;Clinic Visits;Clinical;clinical practice;Cluster Analysis;Communities;concept mapping;Continuity of Patient Care;culturally appropriate intervention;Data;Development;Dimensions;Disparate;Disparity;doctoral student;Dose;Doxycycline;Epidemic;Event;Exercise;experience;Fellowship;Focus Groups;Future;gender minority group;Goals;Health;health disparity;health equity;health inequalities;Health Promotion;Health Services Accessibility;Healthcare;HIV;HIV Infections;improved;Individual;Intervention;Joints;Knowledge;Maps;medication compliance;Mentors;Mentorship;Methodology;Methods;Modeling;National Institute of Nursing Research;novel;Patient Preferences;Patients;Population;population health;pre-exposure prophylaxis;prevent;Prevention;Prevention strategy;Primary Care;primary care clinician;primary care setting;Process;Prophylactic treatment;Protocols documentation;Recommendation;Research;Research Methodology;Research Personnel;response;Risk;Scientific Advances and Accomplishments;Sexual and Gender Minorities;sexual minority group;Sexually Transmitted Diseases;side effect;skill acquisition;skills;Societies;software development;Sorting;STI prevention;Strategic Planning;Structure;success;System;Training;Translational Research;uptake;Virus Diseases;Vulnerable Populations;Writing

PROJECT_TITLE: Client and clinician priorities for same-day PrEP and DoxyPEP awareness, uptake, and persistence in primary care.

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (88)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Patient Safety;Sleep Research;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: The proposed Phase III multi-site randomized-controlled trial will use highly rigorous methodology to determine whether suvorexant is an effective treatment for insomnia in persons maintained on buprenorphine or methadone. The results will also identify key opioid use disorder treatment outcomes that might be targeted for future medication development. The ultimate goal of this study is to update the prescribing guidelines in the label of suvorexant to include the treatment of “Insomnia in persons with opioid use disorder”.

PI_NAMEs: HUHN, ANDREW S (contact)

PROGRAM_OFFICER_NAME: RAMEY, TANYA S

PROJECT_TERMS: abuse liability;Academia;Address;Adverse event;antagonist;Autopsy;Behavior;Benzodiazepines;brain tissue;Buprenorphine;clinical care;Communities;craving;Data;Development;Dose;Double-Blind Method;Drug Screening;drug seeking behavior;effective therapy;efficacy evaluation;Eligibility Determination;Enrollment;Family;FDA approved;Frequencies;Future;Goals;Guidelines;Health Personnel;Human;hypocretin;Hypothalamic structure;illicit opioid;improved;improvement on sleep;Incidence;Individual;Industry;Instruction;Label;Lateral;Lead;Maintenance;Measures;Medical;medication for opioid use disorder;medication safety;Mental Health;Methadone;Methodology;Monitor;Neurons;Neurotransmitters;Opioid;opioid epidemic;opioid use;opioid use disorder;opioid withdrawal;optimal treatments;Outcome;overdose death;Participant;patient safety;Patients;Persons;Pharmaceutical Preparations;Phase;Pilot Projects;Placebos;Polysomnography;pre-clinical;primary endpoint;primary outcome;Provider;Public Health;public health relevance;Quality of life;Randomized;Randomized, Controlled Trials;Rebound Insomnia;receptor;Recovery;reduce symptoms;Relapse;Reporting;Risk;Role;Safety;Site;Sleep;Sleep disturbances;Sleeplessness;Symptoms;System;Therapeutic;Time;Toxicology;translational study;Treatment outcome;Treatment Protocols;Update;Urine;Withdrawal Symptom

PROJECT_TITLE: Phase III double-blind, randomized controlled trial of suvorexant versus placebo to treat insomnia in persons with opioid use disorder

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Medication Development Research Study Section[NIDA-L]


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: The Harvard Summer Research Program in Kidney Medicine (HSRPKM) will recruit and develop the next generation of kidney medicine and urology leaders of diverse backgrounds. The Program is structured around each student’s summer 9-week research experience at one of four Harvard teaching hospitals (Brigham and Women’s Hospital, Massachusetts General Hospital, Beth Israel Deaconess Medical Center, or Boston Children’s Hospital), which is complemented by a core curriculum that teaches kidney physiology and exposes students to the perspectives of people with kidney disease in the community. To provide longer term career development interactions, HSRPKM will keep these talented young scientists engaged with kidney medicine after their summer experience by developing year-round career development and networking events.

PI_NAMEs: BONVENTRE, JOSEPH VINCENT (contact)

PROJECT_TERMS: Academia;Advisory Committees;Affect;Anatomy;Autopsy;Awareness;Biology;Biotechnology;Boston;burden of illness;career;career development;career networking;Caring;Chronic Kidney Failure;Clinical;cohort;college;Communities;curriculum enhancement;Diagnosis;Dialysis procedure;Disease;Educational Curriculum;Educational process of instructing;Effectiveness;effectiveness evaluation;Enrollment;Environment;Event;experience;Exposure to;Faculty;Female;Functional disorder;Funding;Future;General Hospitals;Goals;hands on research;Health;High Prevalence;Home;Hospitals;improved;Individual;Industry;Influentials;innovation;Institution;instrument;interest;Israel;Kidney;Kidney Diseases;Kidney Failure;Laboratories;Massachusetts;Medical center;medical schools;Medicine;member;Mentors;Mentorship;minority communities;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;next generation;novel therapeutic intervention;Outpatients;Pathology;Patients;Pediatric Hospitals;peer;Persons;Physicians;Physiology;Program Appropriateness;Program Development;programs;Race;recruit;Research;Research Personnel;retention rate;Scientist;screening;Site;skills;socioeconomics;Specimen;Structure;student mentoring;student participation;Student recruitment;Students;success;summer research;Surveys;symposium;System;Talents;targeted treatment;Teaching Hospitals;tool;Training;undergraduate student;Underrepresented Populations;United States;Universities;Update;urologic;Urologist;Urology;virtual;Visit;Woman;Work


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_CITY: Nashville

ORG_DEPT: PSYCHOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Given the foundational importance of early brain development for subsequent psychopathology, it is imperative to capture children’s everyday experiences with their caregivers in relation to changes in infant brain development. Addressing the need for more ecologically-valid approaches to our understanding of children’s early experiences, this study uses a newly developed wearable device that can dynamically, unobtrusively, and continuously measure patterns of physical proximity between children and caregivers, regardless of location. The proposed project will yield extraordinary insight into the early environment from a child-centered perspective during the first 18 months of life, with relevance to NIMH’s mission to determine the biological and psychological mechanisms by which the environments affect neural and behavioral development.

PI_NAMEs: HUMPHREYS, KATHRYN LEIGH (contact)

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TITLE: Parent-child proximity and emerging psychopathology


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Physical Injury - Accidents and Adverse Effects

ORG_CITY: ANAHEIM

ORG_NAME: LEBRUN LABS, LLC

PHR: Narrative Currently, there are no accurate nonanimal tests to identify consumer products and chemicals that require labeling to advise users to wear protective eyewear and avoid eye contact due to the threat of serious eye damage. The purpose of this application is to further develop and commercialize a new nonanimal test — the in vitro depth of injury eye irritation test (IVD EIT) — to identify this class of ocular irritants and thereby allow for adequate labeling that will advise and inform users about product safety as well as comply with new laws preventing or limiting the use of animals that have been historically used for this type of routine safety testing. 1

PI_NAMEs: LEBRUN, STEWART  (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: Administrative Supplement;Animal Testing;Animals;Applications Grants;Bachelor's Degree;Benchmarking;Biological Assay;Biological Sciences;Biology;Blinded;Businesses;California;career;Cell Nucleus;Cell Survival;Cells;Chemicals;Classification;commercialization;commercialization readiness;consumer product;Cornea;Corrosives;Data;Data Analyses;Development;Diagnostic Reagent Kits;Dose;Ensure;Epithelium;Equipment;Ethanol;European Union;Evaluation;experience;Eye;Eye Injuries;Felis catus;fluorescence imaging;Future;Goals;Guidelines;Hazardous Substances;Image;improved;In Vitro;in vitro testing;in vivo;Industry;Injury;Internships;Irritants;irritation;Label;Laboratories;Laws;Learning;Location;manufacture;Manufacturer;member;Methods;Microfilaments;Oryctolagus cuniculus;peer;Performance;prevent;Process;Product Labeling;Production;protocol development;Research;research and development;Research Project Grants;Research Proposals;Safety;safety testing;Sensitivity and Specificity;Services;Solid;stability testing;Stains;Students;surfactant;symposium;Techniques;Testing;timeline;Training;United States;Universities;Validation;Work;Writing

PROJECT_TITLE: Joana Romero: IVD EIT - Administrative Supplement to Promote Diversity in Research and Development Small Businesses


NIH_SPENDING_CATS: Hematology;Kidney Disease

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The Summer Undergraduate Program in Emory Renal Research (SUPERR) will provide a research and didactic experience in the study of kidney, urology, and hematologic diseases. Following a national recruitment, the selected students will participate in an 11-week didactic and laboratory or clinical research based experiential program at Emory, culminating with participation in the NIDDK sponsored Summer Student Research Symposium.

PI_NAMEs: COBB, JASON ;PARK, JEANIE  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Admission activity;Affect;African American student;American;Area;career;career development;Caring;Child;Chronic Kidney Failure;Clinic;Clinical Research;clinically significant;college;congenital anomalies of the kidney;cost;Cost of Illness;data acquisition;Disease;Doctor of Philosophy;Economic Burden;Education;Education and Outreach;Educational process of instructing;effective therapy;End stage renal failure;Enrollment;Ethics;experience;Fellowship;Fostering;Funding;Future;Goals;graduate school;graduate student;Health;healthcare burden;Hematological Disease;Hematology;Historically Black Colleges and Universities;Human;Infrastructure;innovation;interest;Internet;Kidney;Kidney Diseases;Knowledge;Laboratories;laboratory experiment;Laboratory Research;Literature;matriculation;Medical;Medical Research;Medical Residency;medical schools;Medical Students;Medicare;meetings;Methods;Minority Groups;Minority Participation;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;next generation;outreach;outreach program;Participant;Patients;Peach;Physicians;Postdoctoral Fellow;Program Development;programs;recruit;Reproducibility;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Training;Science;Scientist;Sickle Cell Anemia;skills;Student Selections;Students;summer student;Surveys;symposium;Testing;Training;Translational Research;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Urinary tract;Urologic Diseases;Urology;Woman


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Patient Safety;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: West Sacramento

ORG_NAME: TENVOS INC.

PHR: Narrative Patients affected by opioid use disorder (OUD) face numerous challenges, ranging from stigma to policy barriers that impede their access to care. Innovative and FDA-cleared opioid use testing methods that can be performed outside of laboratory environments address these issues and hold the promise of increasing retention rates and improving clinical outcomes. A machine learning-based solution that can identify opioid use by analyzing human voice will not only improve clinical outcomes in the outpatient OUD treatment setting but can be adopted in many other settings due to its convenience and can, potentially, unlock new workflows that were not feasible before.

PI_NAMEs: SEIILOVA-OLSON, RIMA  (contact)

PROGRAM_OFFICER_NAME: ANGELONE, LEONARDO MARIA

PROJECT_TERMS: addiction;Address;Administrator;Adopted;Adoption;Affect;Appointment;barrier to care;Blood;Buprenorphine;Caring;Case Management;Clinical;Clinical Data;Correlation Studies;Counseling;COVID-19 pandemic;Data;Devices;Drops;Drug abuse;drug testing;Environment;Face;Feedback;Hair;Health Personnel;Health Services Accessibility;High Prevalence;Home;Hospitalization;Human;improved;improved outcome;Individual;innovation;inpatient service;Inpatients;Investments;Laboratories;Machine Learning;machine learning model;Managed Care;medication for opioid use disorder;Methadone;Methods;Modeling;Nature;non-compliance;Notification;Opioid;opioid use;opioid use disorder;Outcome;Outpatients;Overdose;Pathway interactions;patient monitoring device;Patients;Performance;Persons;Phase;physical sample collection;Physicians;Policies;Population;population health;Process;programs;Provider;Radiologic Health;Relapse;remote patient monitoring;retention rate;Risk;risk stratification;Saliva;Sampling;Sensitivity and Specificity;Services;smartphone application;social stigma;software as a medical device;System;Telemedicine;Test Result;Testing;Therapeutic;Time;Transportation;Urine;virtual;virtual health;Visit;Voice;wearable device;Work

PROJECT_TITLE: Software as a Medical Device for detecting opioid use through voice.

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SUY-S (J1)]


NIH_SPENDING_CATS: Cancer;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

PI_NAMEs: ZHANG, ZHEN  (contact)

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Hematology;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: HOUSTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE Sickle cell disease (SCD) is a genetic disease that affects millions of people worldwide. Although multiple SCD gene therapies are undergoing clinical trials, significant challenges concerning the safety and efficacy of CRISPR/Cas9 gene editing remain to be addressed, including the unintended small and large gene modifications at the Cas9 on-target cut-sites. This Diversity Supplement will provide the support to an underrepresented minority PhD student to determine the biological consequences of gene editing induced small in-frame mutations and investigate the impact of modulating DNA repair pathways in gene-editing based treatment of SCD.

PI_NAMEs: BAO, GANG  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Address;Adverse effects;Affect;Allogenic;Alloimmunization;American;Autologous;base editing;beta Globin;Biological;Blood specimen;Bone Marrow;Cell model;Cells;Chronic;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR/Cas technology;curative treatments;design;DNA;DNA Repair;DNA Repair Pathway;doctoral student;Engraftment;Enhancers;Erythroid;Erythropoiesis;Evaluation;Fetal Hemoglobin;Frequencies;Gene Modified;gene therapy;Genes;Genetic Diseases;genome editing;Genotype;Goals;graft vs host disease;Grant;Guide RNA;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Immunodeficient Mouse;improved;insertion/deletion mutation;Intervention;Iron Overload;K-562;Lymphoid;Mendelian disorder;Methods;Mus;Mutation;Myelogenous;Nonhomologous DNA End Joining;Outcome;parent grant;Parents;Pathway interactions;Patients;peripheral blood;Persons;pharmacologic;Pharmacological Treatment;Phenotype;repaired;Reporter;Research;Risk;Safety;Severity of illness;Sickle Cell Anemia;sickling;Site;small molecule;Testing;therapeutic genome editing;Time;Transfusion;Translations;Underrepresented Minority;underrepresented minority student

PROJECT_TITLE: Deciphering unintended large gene modifications in gene editing for sickle cell disease


ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

PHR: This proposal will investigate the role of neuroinflammation as a driver of neuropathology following repeat traumatic brain injury (TBI) – which affects over 2.8 million people in the U.S. each year – as we will measure inflammation-related genomic, cellular, and behavioral changes and correlate these to neuropathological consequences using a unique swine model of clinically relevant TBI. First, we will ascertain the underlying genetic and molecular factors contributing to post-TBI neuroinflammation following mild or moderate TBI, followed by a study correlating the extent of behavioral and cognitive deficits with these genetic and molecular changes. Finally, we will test the effect of repeat TBI on genomic, cellular, and behavioral changes during and after a period of neuroinflammation triggered by an initial TBI. This work will guide future studies by comprehensively characterizing genomic, pathological, and cognitive changes after clinically relevant TBI and establish susceptibility to deficiencies in neuronal and neurocognitive health following repeat TBI.

PI_NAMEs: CULLEN, DANIEL KACY (contact)

PROJECT_TERMS: Acceleration;Address;Affect;American;Animal Model;Animals;Association Learning;Axon;axonal degeneration;Behavior;behavior measurement;Behavioral;Biological Models;Biomechanics;Brain;brain cell;Brain Concussion;brain dysfunction;brain size;brain tissue;Cells;Central Nervous System;clinically relevant;Cognitive;cognitive change;Cognitive deficits;cognitive task;cohort;Contusions;Correlation Studies;Craniocerebral Trauma;data access;Data Set;density;Diffuse;Disease;Edema;Etiology;Event;excitotoxicity;experience;Family suidae;Functional disorder;Future;Gene Expression;Gene Expression Profiling;Genetic;Genomics;glial activation;gray matter;Head;Health;health economics;Hematoma;Hippocampus;Histologic;Human;human model;Human Pathology;Hypertrophy;Hypoxia;Immune;immune activation;immune cell infiltrate;Immunohistochemistry;Impaired cognition;improved;Inflammation;Inflammatory;Injury;Investigation;Learning;Measures;Mechanics;Memory;Methodology;Microglia;migration;mild traumatic brain injury;Modeling;Molecular;Monitor;Morphology;motor disorder;Nerve Degeneration;neural circuit;Neuroanatomy;neurobehavior;neurobehavioral;Neurocognitive;Neurocognitive Deficit;neuroinflammation;neuron loss;Neurons;neuropathology;neurophysiology;Outcome;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Persons;Phenotype;physical insult;Play;porcine model;Predisposition;progressive neurodegeneration;protein expression;Regional Anatomy;Research Personnel;Resources;response;Rodent;Rodent Model;Role;Rotation;Series;Severities;Short-Term Memory;socioeconomics;spatial memory;Statistical Models;Synapses;Synaptic plasticity;synaptic pruning;Techniques;Testing;therapeutic target;time use;Tissues;transcriptome sequencing;transcriptomic profiling;transcriptomics;Traumatic Brain Injury;Traumatic Brain Injury recovery;United States;visual motor;white matter;Work

PROJECT_TITLE: Neuroinflammatory Status as a Driver of Pathophysiology Following Repetitive Traumatic Brain Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURC-H (01)]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE More than three out of four new HIV infections among young adults in the United States occur among young men who have sex with men (YMSM). Although pre-exposure prophylaxis (PrEP) is highly effective in preventing HIV, evidence indicates that many YMSM who initiate PrEP stop taking it and continue to engage in HIV risk behaviors. We will use implementation science to facilitate delivery of the CDC-recommended evidence-based practices motivational interviewing and personalized health education in two clinics providing PrEP services to increase retention in care and use of PrEP and other HIV prevention methods among YMSM.

PI_NAMEs: BARNETT, ANDREW P (contact)

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: Academic Medical Centers;Address;Administrator;Adolescent and Young Adult;Age;AIDS prevention;Behavioral;career;Caring;Clinic;Clinical;Clinical Psychology;Cluster Analysis;Cluster randomized trial;Communities;condomless anal sex;condoms;Contracts;Counseling;Couples;Data;design;Development;Doctor of Philosophy;Dropout;Drops;Effectiveness;effectiveness/implementation hybrid;enhanced care;Enrollment;evidence base;evidence based guidelines;Evidence based practice;experience;Feedback;follow-up;Funding;Future;gender minority youth;Goals;Grant;health care settings;health disparity;Health education;Health Services;Healthcare;HIV;HIV Infections;HIV prevention trial;HIV risk;Human immunodeficiency virus test;implementation evaluation;implementation facilitation;implementation outcomes;implementation research;implementation science;implementation strategy;improved;Incidence;Infection;Injectable;innovation;Intervention;Interview;Investigation;K-Series Research Career Programs;Knowledge;Lesbian Gay Bisexual Transgender Queer;Linear Models;medical schools;men who have sex with men;Mentors;Mentorship;Methods;Modality;Motivation;motivational enhancement therapy;novel;Nurses;outreach;Patient Dropouts;patient oriented;Patients;Postdoctoral Fellow;pre-exposure prophylaxis;prevent;Prevention;Prevention approach;Prevention program;prevention service;Promoting Action on Research Implementation in Health Services framework;Provider;Recommendation;Reporting;Research;Research Ethics;Research Personnel;Risk Behaviors;seroconversion;Services;sexual minority youth;side effect;skills;Social Workers;Supervision;Time;Training;Training Activity;United States;United States National Institutes of Health;Universities;young adult;young men who have sex with men;Youth

PROJECT_TITLE: Using Implementation Science to Enhance HIV Prevention for Young Men who have Sex with Men

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: The SPURRS program will result in greater participation in kidney-related research by young scientists and physician-scientists. This participation will benefit society as a whole by enhancing the research workforce, including under-represented minorities, to solve pressing problems brought on by the increasing burden of acute and chronic kidney disease.

PI_NAMEs: REEVES, WILLIAM BRIAN (contact)

PROJECT_TERMS: Acute;Address;Affect;Biomedical Research;career;career development;Chronic Kidney Failure;Cities;Clinical;cohort;college;Critical Thinking;curriculum development;Detection;Development;education research;Expenditure;experience;Exposure to;Fellowship;Funding;Future;Goals;hands on research;Health;Hematological Disease;improved;Infrastructure;inquiry-based learning;interest;Investigation;Kidney;Kidney Diseases;knowledge base;Location;medical schools;Medicare;Medicine;Mentors;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;next generation;novel strategies;novel therapeutics;peer;Physicians;Population;Positioning Attribute;Prevention approach;programs;Qualifying;recruit;Research;research and development;Research Personnel;response;Science;Scientist;skills;Societies;stem;student retention;Students;success;summer research;summer student;symposium;Texas;Time;tool development;Training;Training Programs;trend;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;Universities;Urologic Diseases

PROJECT_TITLE: San Antonio Program for Undergraduate Research in Renal Science (SPURRS)

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: SAINT PAUL

ORG_NAME: QUENCH MEDICAL, INC.

PHR: Project Narrative  Opioid use disorder is characterized by a problematic pattern of opioid use causing significant personal impairment or distress and too frequently leads to overdose and death. In 2021, there were 106,699 Americans who died from an opioid related overdose. 5-MeO-DMT is a psychoplastogenic compound that has shown some promise in several psychopathological disorders, including substance use disorders, but little is known about the effect on opioid use disorder and dose delivery remains a concern with current technologies. There is evidence that a highly targeted pharmaceutical aerosol formulation can overcome current drug delivery limitations, therefore, we will develop a novel inhaled 5-MeO-DMT formulation and test in an animal model of opioid use disorder to improve the lives of persons living with this deadly disease.

PI_NAMEs: BEVERLIN II, BRYCE  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, TAM L

PROJECT_TERMS: Address;Aerosols;American;Animal Model;Anxiety;Benchmarking;Biological Availability;buprenorphine treatment;Cessation of life;Characteristics;Clinical Research;Collection;Data;Data Analyses;Dependence;Disease;disease model;Distress;Dose;Drug Delivery Systems;drug development;drug inhalation;Drug Kinetics;drug seeking behavior;Drug usage;Dryness;efficacy study;efficacy testing;Excipients;feasibility testing;first-in-human;Formulation;Goals;Growth;high risk;Impairment;improved;in vivo;in vivo evaluation;Inhalation;Investigational Drugs;Lead;liver metabolism;Lung;manufacture;Medical;Medical Technology;meetings;Mental Depression;meter;Modeling;Neuronal Plasticity;novel;novel drug class;Opioid;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;Participant;Particle Size;Patients;Pattern;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Pharmacology;Phase;Powder dose form;pre-clinical;Process;Production;Rodent Model;Route;Self Administration;Severities;standard of care;Substance Use Disorder;success;Symptoms;Technology;Testing;Therapeutic;Toxicology;Universities;Virginia;Withdrawal

PROJECT_TITLE: A novel inhaled dry powder psychoplastogenic formulation for treating persons with opioid use disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-S (14)]


ORG_CITY: NEW YORK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The overarching goal of the parent PPG is to define the molecular mechanisms that regulate local calcium (Ca2+) signaling in normal and failing hearts with unprecedented precision. There are three goals shared by the four projects: 1) explore the precise role of adrenergic signaling in modulating calcium in normal and failing hearts; 2) define novel mechanisms of interactions between T-tubule and sarcoplasmic reticulum (SR) calcium channels; 3) develop new understandings of genetic based mechanisms of inherited forms of CV disease involving calcium. Project four provides the essential link to SR calcium release by studying the structure- function relationships of the type 2 ryanodine receptor (RyR2)/calcium release channel present on the sarcoplasmic and endoplasmic reticula (SR/ER) of many cell types in the context of heart failure.

PI_NAMEs: COLECRAFT, HENRY M. (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Address;Adrenergic Agents;Arrhythmia;Back;Binding;Biological Assay;Calcium;Calcium Channel;Calcium Signaling;Cardiac;Cardiomyopathies;Catecholaminergic Polymorphic Ventricular Tachycardia;cell type;ClinVar;cohort;Complex;Congestive Heart Failure;Consanguinity;Coupling;Cryoelectron Microscopy;Cyclic AMP-Dependent Protein Kinases;Data;Disease;Endoplasmic Reticulum;Exercise;gain of function;gain of function mutation;Genetic;genome resource;Goals;Heart;Heart failure;heart failure with reduced ejection fraction;Human;Impairment;Individual;Inherited;Link;Mediating;Missense Mutation;Molecular;mutant;Mutation;Myocardium;novel;novel therapeutics;Pakistan;Parents;Pathologic;Patients;Pharmaceutical Preparations;phenotypic data;Phosphorylation;Physiology;Post-Translational Protein Processing;prevent;receptor function;Role;Ryanodine Receptor Calcium Release Channel;Sarcoplasmic Reticulum;Signal Transduction;Stress;Structure;Structure-Activity Relationship;Sudden Death;Variant;Ventricular Arrhythmia

PROJECT_TITLE: Structure-Function of Calcium Channel Complexes in Cardiac Physiology and Disease


NIH_SPENDING_CATS: Cardiovascular;Hypertension

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: The proposed research is relevant to public health because the discovery of new signaling pathways that regulate blood pressure at the level of contractility of smooth muscle that makes up the walls of blood vessels will contribute to the development of improved therapies for treatments of diseases associated with SM contractile dysfunction such as hypertension and asthma. New drug targets are important as a sizable cohort of patients with hypertension do not respond well to current drugs. Drugs targeting this pathway will be tested in a hypertensive animal model. Such findings are relevant to the part of NIH’s mission that pertains to developing fundamental knowledge that will help to protect and improve health.

PI_NAMEs: DEREWENDA, ZYGMUNT S;SOMLYO, AVRIL V. (contact);SONKUSARE, SWAPNIL K.

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Address;Agonist;Animal Model;Arteries;arteriole;Asthma;Blood capillaries;Blood flow;blood pressure reduction;blood pressure regulation;Blood Vessels;cohort;cost;Data;Development;Disease;Drug Targeting;Dysbarism;Functional disorder;Guanine Nucleotide Exchange Factors;Health;Hypertension;hypertensive;improved;inhibitor;Knowledge;knowledge base;Mediating;Mission;Mus;Muscle Contraction;Muscle Tonus;MYLK gene;Myosin ATPase;new therapeutic target;novel;Nucleotides;Outcome;Pathology;Pathway interactions;Patients;Perfusion;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Physiology;pressure;Public Health;Regulation;Research;Resistance;response;Ribosomal Protein S6 Kinase;Ribosomes;RPS6KA gene;Signal Pathway;Signal Transduction;Smooth Muscle;Testing;United States National Institutes of Health;Vascular resistance;Vascular Smooth Muscle;vasoconstriction;Wild Type Mouse

PROJECT_TITLE: Cost Extension for Ramon Ayon Diversity Supplement


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE This project will introduce and validate wastewater surveillance for HIV and TB in Eswatini, a high burden setting for both diseases. First, we will introduce and validate techniques for wastewater surveillance of HIV and TB; second, correlate wastewater detection of HIV and TB with public health epidemiological data; and third, evaluate the impact of proven public health prevention and case-finding strategies on levels of TB and HIV in wastewater. The candidate’s approach blends innovative science with strong long-term partnerships with multiple stakeholders in Eswatini, and if successful will help catalyze the drive to end HIV and TB in high burden settings.

PI_NAMEs: KAY, ALEXANDER WILLIAM (contact)

PROJECT_TERMS: Achievement;Africa South of the Sahara;Area;case finding;Child;Clinical Research;college;Communities;Community Health;Complement;cost effective;Country;Data;Data Reporting;Detection;detection platform;Disease;emerging pathogen;epidemiologic data;Epidemiology;epidemiology study;experience;Female Adolescents;fighting;Grant;Health;Health care facility;HIV;HIV Infections;HIV/TB;Hospitals;Immunology;improved;Incidence;innovation;Intervention;Lead;Measures;Medicine;pathogen;Pathogen detection;Patients;Persons;Phase;Positioning Attribute;Prevalence;Prevention;Prevention strategy;programs;Public Health;public health intervention;Resource-limited setting;response;Sampling;Science;Security;Site;success;System;Techniques;Testing;tool;transmission process;virology;wastewater samples;wastewater sampling;wastewater surveillance

PROJECT_TITLE: Wastewater surveillance to enhance the public health response to HIV and TB in Eswatini

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-P (55)]