NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: XU, JUN  (contact)

PROJECT_TERMS: Address;anti-cancer research;cancer cell;Cancer cell line;Cancer Center;Cancer Center Support Grant;cancer heterogeneity;Cancer Patient;cancer stem cell;Cell Line;Cell model;Cell Reprogramming;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;college;Complement;Complementary DNA;Computers and Advanced Instrumentation;cost;CRISPR/Cas technology;Development;Disease remission;Elements;Epigenetic Process;established cell line;functional genomics;gene editing technology;gene function;Gene Targeting;Genes;Genetic;Genetic Screening;Genetic Transcription;Genome;genome editing;genome resource;genome-wide;Genomic Library;Genomics;Goals;Housing;Human;Human Characteristics;human pluripotent stem cell;improved;Individual;induced pluripotent stem cell;Investigation;Laboratories;Lentivirus;Libraries;Malignant Neoplasms;Mammalian Cell;Mediating;Medicine;member;model organism;Modeling;Modification;Mutation;neoplasm resource;neoplastic cell;new therapeutic target;Pathway interactions;Patients;personalized cancer therapy;personalized therapeutic;Physiological;Preparation;Production;protein function;Proteins;Research;Research Personnel;Resource Sharing;Resources;RNA Interference;Robotics;Services;small hairpin RNA;Somatic Cell;stem cells;System;Technology;technology development;tool;Transfection;tumor;Tumor Suppressor Genes;vector;whole genome;Work

PROJECT_TITLE: Gene Modulation inCancer Cellular Models


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PI_NAMEs: CHEN, RUI  (contact)

PROJECT_TERMS: Acceleration;Adoption;anti-cancer research;Awareness;Bioinformatics;Biological Assay;Biological Process;cancer cell;Cancer Center;Cancer Center Support Grant;Cells;Chromatin;college;community center;Complex;Comprehensive Cancer Center;Computational Biology;computerized data processing;Consultations;cost;cost effective;Cost efficiency;Custom;Data;Data Analyses;data management;Data Storage and Retrieval;design;Detection;Development;differential expression;Disease;Disease Progression;DNA;DNA Methylation;Education;Educational workshop;Emerging Technologies;Ensure;Epigenetic Process;epigenome;epigenomic profiling;epigenomics;exome;experience;Experimental Designs;flexibility;Funding;Gene Expression;Gene Expression Profiling;Gene Mutation;Gene Rearrangement;Genes;Genome;genome sequencing;Genomics;Genomics Shared Resource;Germ-Line Mutation;Goals;Grant;Heterogeneity;histone modification;Individual;innovation;insight;instrument;instrumentation;interest;Investments;Libraries;Malignant Neoplasms;Medicine;member;Mission;Modification;Molecular Biology;Molecular Conformation;Mutation;NCI Center for Cancer Research;new technology;next generation sequencing;operation;Pathway interactions;Positioning Attribute;Predisposition;Preparation;Production;programs;Protein Isoforms;Protocols documentation;Quality Control;Research;Research Personnel;Research Project Grants;Research Support;Resolution;Resource Sharing;RNA;Sampling;Services;single cell ATAC-seq;single cell genomics;single cell sequencing;single cell technology;Single Nucleotide Polymorphism;single-cell RNA sequencing;Somatic Mutation;Specialist;Speed;success;targeted sequencing;Technology;Tissues;Training;Training and Education;Transcript;transcriptome;transcriptome sequencing;transcriptomics;treatment response;tumor progression;Vendor;whole genome;Work

PROJECT_TITLE: Genomic, Transcriptomic, Epigenomic and Single Cell Shared Resource

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative This study will provide high-quality, representative data on the capacity of Elevating Voices, Addressing Depression, Toxic Stress and Equity in Group Prenatal Care (EleVATE GC) to reduce perintal depression, preterm birth, and low birthweight in African-American women. If findings from this study indicate that EleVATE GC is feasible and effective, this model could be implemented nationwide to help achieve mental and obstetric health parity for low-income women of color in the United States.

PI_NAMEs: CARTER, EBONY BOYCE;LENZE, SHANNON NICOLE (contact)

PROGRAM_OFFICER_NAME: MAVANDADI, SHAHRZAD

PROJECT_TERMS: Address;Adverse event;adverse pregnancy outcome;Affect;African American Women;antepartum depression;Anxiety;Anxiety Disorders;Appointment;Area;behavioral health intervention;Birth Rate;Caring;Chronic Disease;Clinic;Collaborations;Data;Diagnosis;Discipline of obstetrics;Disease Management;disparity reduction;effectiveness evaluation;effectiveness testing;effectiveness-implementation RCT;Enrollment;Equity;Event;evidence base;experience;Exposure to;Face;Health;high risk;High Risk Woman;implementation context;implementation determinants;implementation strategy;improved;improved outcome;Individual;Insurance Coverage;Intervention;Life;Low Birth Weight Infant;Low income;maternal risk;Medicaid;Mental Depression;Mental Health;Mental Health Services;Minority Women;Modeling;Mood Disorders;Neonatal;novel;Outcome;outcome disparities;parity;Patients;Perinatal;peripartum depression;pilot trial;Population;Postpartum Depression;Practical Robust Implementation and Sustainability Model;Pregnancy;Pregnant Women;Premature Birth;prenatal;Prenatal care;primary outcome;programs;Provider;Psyche structure;psychological distress;Psychosocial Stress;racism;Recording of previous events;Research Personnel;Resources;Risk;secondary outcome;Services;Site;Stigmatization;Stress;System;Testing;therapy design;Time;Trauma;trial comparing;Underserved Population;United States;Voice;White Women;Woman;women of color


NIH_SPENDING_CATS: Bioengineering;Cancer

PI_NAMEs: PUTLURI, NAGIREDDY  (contact)

PROJECT_TERMS: anti-cancer research;Biological;Biological Markers;Biological Models;biomarker panel;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Model;Cancer Research Project;candidate identification;Carbon;Cell Line;Cells;Citric Acid Cycle;Clinical;clinical investigation;clinical translation;college;Column Chromatography;Communication;Comprehensive Cancer Center;Computing Methodologies;Consultations;Data;Data Analyses;Data Analytics;Databases;Dedications;Development;Disease;Early Diagnosis;Emerging Technologies;experience;Experimental Designs;Experimental Models;fatty acid biosynthesis;Folic Acid;Generations;Genetic;Glucose;Glutaminase;Glutamine;Glycolysis;Goals;Grant;In Vitro;in vivo;in vivo Model;Infrastructure;innovative technologies;insight;instrument;instrumentation;interest;Journals;Label;lipidomics;Lipids;Liquid Chromatography;liquid chromatography mass spectrometry;Liquid substance;Malignant Neoplasms;mass spectrometer;Mass Spectrum Analysis;Measurement;Measures;Medicine;member;Metabolic;Metabolic Marker;Metabolic Pathway;metabolic profile;Metabolism;metabolome;metabolomics;metabolomics resource;Methionine;Methods;Mission;Molecular;Monitor;Multiomic Data;Mus;Nature;NCI Center for Cancer Research;nucleotide metabolism;nutrition;operation;oxidation;Pathologic;Pathway interactions;Pentosephosphate Pathway;Physiological;Play;Positioning Attribute;Prognosis;programs;Proteins;Publications;Publishing;Reaction;Reporting;Research;Research Personnel;Resource Sharing;Role;Sampling;Science;Services;Shotguns;small molecule;Specimen;Stable Isotope Labeling;Standardization;System;Technology;technology platform;Therapeutic;Time;Tissues;Translating;triple-negative invasive breast carcinoma;Tryptophan;tumor;tumor progression;Tumor-Derived;Work

PROJECT_TITLE: Metabolomics Shared Resource


NIH_SPENDING_CATS: Cancer;Prevention

PI_NAMEs: BEETON, CHRISTINE  (contact)

PROJECT_TERMS: angiogenesis;anti-cancer research;Antibodies;Award;Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer prevention;cancer stem cell;cancer therapy;Cell Communication;Cell Cycle Progression;Cell Separation;Cell Survival;cell type;Cells;Cellular Metabolic Process;Chromatin;college;Consultations;Core Facility;cost effective;Cytometry;Data Analyses;data management;Development;DNA;Ensure;Equipment;Evolution;experience;Flow Cytometry;Funding;Future;Generations;Genetic Transcription;Goals;Grant;Growth;Hour;Image;imaging platform;imaging system;Immune;In Situ;Individual;Inflammation;instrument;instrumentation;Laboratories;Letters;Life;Magnetism;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant Neoplasms;Medicine;meetings;member;Metals;Mutation;Neoplasm Metastasis;neoplastic cell;new technology;new therapeutic target;novel;novel therapeutics;Nuclear Receptors;Oncogenes;particle;Peer Review;Phenotype;Preparation;prevent;programs;Protocols documentation;Publications;Reagent;recruit;repaired;Research;Research Design;Research Institute;Research Personnel;Resource Sharing;Resources;Sampling;Services;Signal Pathway;Signal Transduction;Sorting;submicron;success;Suspensions;Technology;Texas;tissue culture;Tissue Sample;Tissues;tool;Training;Transcriptional Regulation;transforming virus;Translating;tumor;tumor eradication;tumor microenvironment;Tumor Suppression;Tumor Suppressor Proteins;Work

PROJECT_TITLE: High-Parameter Cytometry Shared Resource


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Social Determinants of Health;Substance Misuse

ORG_CITY: WASHINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Latinos are the largest and fastest growing ethnic minority group in the U.S., yet they are significantly underrepresented at all levels of appropriate academic programs critical for entry to health profession careers. Through an intensive summer training program, the Latino Scholars in HIV/AIDS Research Education (SHARE) at The George Washington University will enable undergraduate students to attain advanced education in behavioral-social science research of HIV and substance use disorders. The expectation is to facilitate their success in future academic and research endeavors, further promote educational and career opportunities in critical STEM fields, and enhance diversity of the research workforce.

PI_NAMEs: DEL RIO-GONZALEZ, ANA MARIA  (contact);STOFF, DAVID

PROGRAM_OFFICER_NAME: FRIEND, LINDSEY NICOLE

PROJECT_TERMS: academic program;Address;Applications Grants;Awareness;behavioral and social science;Behavioral Research;career;Career Mobility;Cognitive;comorbidity;Competence;Continuity of Patient Care;Data;Data Analyses;Development;Education;education research;Educational Activities;Educational Curriculum;Educational workshop;Effectiveness;ethnic minority population;expectation;experience;Future;Gender;Goals;graduate school preparation;hands on research;health inequalities;Health Occupations;Health Professional;health science research;HIV;HIV/AIDS;human subject;improved;Individual;innovation;intersectionality;Knowledge;Latino;Latino Population;lectures;Measures;Mediator;Mentors;Modeling;National Institute of Drug Abuse;Outcome;Participant;peer;peer coaching;Play;Population;posters;Preparation;Prevention;Productivity;programs;prospective;psychologic;Public Health;Public Speaking;Publications;Qualifying;racial minority population;rapid growth;recruit;Research;Research Activity;Research Design;Research Personnel;research study;responsible research conduct;Role;Science;Scientist;Self Efficacy;Series;skill acquisition;skills;social;Social Behavior;social health determinants;social science research;STEM field;Strategic Planning;Students;Substance Use Disorder;success;summer research;theories;Training;Training Programs;Translating;undergraduate student;United States;United States National Institutes of Health;Universities;Washington


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE  Unlike antipsychotics and all other psychoactive medications, antiepileptic drugs prescribed in US nursing homes are not mandatorily reported to CMS via the Minimum Data Set, and details of both their use and the adverse health outcomes associated with their use are unknown. This knowledge gap is meaningful since pilot data suggests that off-label unmonitored antiepileptic prescribing for the behavioral and psychological symptoms of dementia is increasing as other monitored medications are used less in response to purposeful reduction efforts, a change in management approach that has accelerated over the COVID-19 pandemic. We propose a mixed-methods approach including both a retrospective analysis and a national survey to describe appropriate and potentially inappropriate antiepileptic and other psychoactive prescribing in US nursing homes, characteristics and patient-oriented outcomes associated with this prescribing, and how these phenomena may be changing under the combined stressors of the COVID pandemic and the pressure of reduction initiatives.

PI_NAMEs: WINTER, JONATHAN DAVID (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acceleration;Adverse event;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease related dementia;anti-epileptic agents;Antipsychotic Agents;Attitude;Behavior;Behavioral Symptoms;Belief;Black race;Caring;Cessation of life;Characteristics;Cognitive;cohort;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Set;Dementia;dementia care;Diagnosis;Diagnostic;disparity reduction;Drug Prescriptions;Drug usage;Elements;Emergency department visit;Epilepsy;Event;falls;gender disparity;Goals;Health;Home Nursing Care;hospice environment;Hospital Records;Hospitalization;improved;Individual;innovation;Knowledge;Label;Link;Measures;Medical;Methods;Monitor;Moods;National Institute on Aging;neuropsychiatric symptom;Nursing Homes;Outcome;palliative;pandemic disease;pandemic stress;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;Pilot Projects;Planning Theory;Policies;Policy Maker;Population;pressure;Prevalence;psychological symptom;Psychotropic Drugs;racial disparity;Research;Resources;response;Risk;Role;Safety;Sampling;statistics;stressor;Surveys;Symptoms;trend;Vulnerable Populations

PROJECT_TITLE: Prescribing trends and associated outcomes of antiepileptic drugs and other psychoactive medications in US nursing homes surrounding the COVID-19 pandemic

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-K(90)]


PI_NAMEs: MALOVANNAYA, ANNA  (contact)

PROJECT_TERMS: Acceleration;Acute;Address;Affinity;anti-cancer research;Antibodies;Antineoplastic Agents;Big Data;Binding Proteins;Biological Assay;Biology;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer proteomics;Cell Physiology;Chemicals;Clinical;clinical development;college;Complex;Custom;Data;Data Analyses;data communication;Decision Making;Dependence;Development;diagnostic assay;DNA Damage;DNA-Protein Interaction;drug action;Enzymes;Event;experimental analysis;Expression Profiling;Follow-Up Studies;Gene Proteins;Genomics;Goals;informatics tool;instrumentation;Knowledge;Laboratories;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Medicine;Methods;Molecular;Mus;new technology;new therapeutic target;novel;Oncogenic;patient derived xenograft model;Phase;Post-Translational Protein Processing;pre-clinical;predicting response;Protein Array;Protein Biochemistry;Protein Dynamics;protein expression;protein function;protein profiling;Proteins;Proteome;Proteomics;Proteomics Shared Resource;repaired;Research;Research Design;Research Personnel;Resistance;resistance mechanism;Resource Sharing;Role;Sampling;Services;Signal Pathway;Signaling Protein;small molecule therapeutics;Technology;technology platform;therapeutic biomarker;Therapeutic Intervention;therapeutic target;tool;transcriptomics;translational study;tumor progression;tumor xenograft;Work

PROJECT_TITLE: Proteomics Shared Resource


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The Johns Hopkins Division of Infectious Diseases has a strong history of over 25 years of training academics researchers, government and industry leaders, and expert hospital epidemiologists and clinicians. Continued funding will allow us to provide a dynamic, highly collaborative training environment with outstanding research opportunities, a structured supportive training process that consistently trains research-naïve physicians, producing productive physician-investigators who have successfully competed for extramural funds after program graduation. Our training program promotes the academic success of physicians from underrepresented groups and women who are critically needed for the future of academic medicine and public health.

PI_NAMEs: COSGROVE, SARA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: microbial disease;Research Training

PROJECT_TITLE: Research Training in Microbial Diseases

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Networking and Information Technology R&D (NITRD)

PI_NAMEs: HILSENBECK, SUSAN G. (contact)

PROJECT_TERMS: Advisory Committees;Applications Grants;Area;Basic Science;Bioinformatics;bioinformatics infrastructure;biomedical informatics;Biometry;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Science;cancer therapy;Clinical;Clinical Research;Clinical Sciences;cluster computing;Collaborations;college;Community Health Education;Community Outreach;Comprehensive Cancer Center;computer infrastructure;Computer software;Data;data analysis pipeline;data management;design;Education;Experimental Designs;Faculty;Funding;Future;High Performance Computing;high throughput technology;Human Resources;improved;informatics shared resource;Information Technology;Infrastructure;innovation;Journals;Leadership;Licensing;Malignant Neoplasms;Medicine;member;Methods;Mission;Monitor;multiple omics;Names;Patient Care;Peer Review;Peer Review Grants;Play;Positioning Attribute;Prevention;Publications;recruit;Research;Research Support;Resource Sharing;Resources;response;Role;Science;Services;Source;Strategic Planning;Students;Technology;Training and Education;Translational Research;virtual

PROJECT_TITLE: Quantitative Science Shared Resource


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome

PI_NAMEs: ROWLEY, DAVID R (contact)

PROJECT_TERMS: Basic Science;Biochemistry;Biological;Biological Factors;Biophysics;Bladder;Budgets;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer health disparity;cancer type;career;Catchment Area;cell type;Cells;Cellular biology;Cellular Metabolic Process;Chad;Clinical;Collaborations;college;Communication;Coupled;Data;data integration;Development;Discipline of obstetrics;Disease;drug discovery;Education;epigenomics;epithelial to mesenchymal transition;Fostering;Funding;Future;gastrointestinal;Gene Expression;genomic data;Genomics;Goals;Gynecology;Head and Neck Cancer;health care disparity;Human Genetics;Immunology;in vitro Model;in vivo;innovation;inter-institutional;Joints;Liver;Lung;Malignant Neoplasms;Manuscripts;Mediator;Medicine;meetings;member;Metabolic;Metabolic Pathway;Metabolism;metabolomics;metastatic process;Molecular;Molecular and Cellular Biology;Molecular Biology;Molecular Genetics;Multiomic Data;multiple omics;Names;novel diagnostics;novel therapeutic intervention;Obesity;Operative Surgical Procedures;Outcome;Pancreas;Pathology;Pathway interactions;Pediatrics;Peer Review;Phenotype;Physiology;prognostic;programs;Prostate;Publications;Publishing;Research;Signal Pathway;Signal Transduction;Smoking;Structure;Subgroup;Therapeutic;therapy resistant;Tissues;Translating;Translations;tumor;tumor metabolism;tumor microenvironment;tumor progression;United States National Institutes of Health;Work;working group

PROJECT_TITLE: Cell Signaling and Metabolism


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cancer;Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Depression;Digestive Diseases;Mental Health;Neurosciences;Pain Research;Palliative Care;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Head and neck cancer patients experience severe pain and stress. The proposed studies investigate how sympathetic and sensory nerves interact to drive cancer pain and promote cancer growth. This approach has the potential for new therapeutic strategies to treat cancer progression and pain by targeting neurons.

PI_NAMEs: SCHEFF, NICOLE N (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Address;Adrenergic Agents;Adrenergic Antagonists;Adrenergic beta-Antagonists;Adrenergic Receptor;afferent nerve;Afferent Neurons;Aftercare;Animal Model;antagonist;Anxiety;Behavior;Behavioral;Benign;beta-adrenergic receptor;Biological;Breast;Calcium;cancer cell;cancer diagnosis;cancer invasiveness;cancer pain;Cancer Patient;carcinogenesis;Catecholamines;Cell Proliferation;Cells;chemical carcinogen;chronic pain;Chronic stress;Clinical;Clinical Trials;Combined Modality Therapy;Data;Disease Progression;Dose;drinking water;Electrophysiology (science);emotional experience;experience;gastrointestinal;Goals;Growth;Growth and Development function;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;improved outcome;In Vitro;in vivo;Incidence;Inflammation;Injury;Long-Term Effects;malignant mouth neoplasm;Malignant Neoplasms;Measures;Mediating;Mediator;Mental Depression;Metastatic Neoplasm to Lymph Nodes;Microscopy;mouse model;Mus;Nerve;nerve supply;Neurons;Neuropeptides;neurotransmission;Nociception;Norepinephrine;novel therapeutic intervention;Optics;Oral;Oral cavity;oral lesion;orofacial;Pain;pain behavior;Pain management;pain symptom;palliation;Patient Outcomes Assessments;Patients;Peripheral;Peripheral Nerves;Phase;Physiological;Plasma;pre-clinical;Pre-Clinical Model;Predisposition;prognostic;prognostic indicator;Propranolol;prospective;Prostate;Psychological Impact;Psychological Stress;psychological symptom;psychosocial;Psychosocial Stress;Quality of life;receptor expression;receptor function;Receptor Signaling;Reporting;Resolution;Risk Factors;Signal Transduction;Social support;Stains;Stress;Survivors;survivorship;Sympathectomy;Sympathetic Nervous System;Symptom Burden;Testing;Therapeutic;Tongue;Treatment Protocols;Treatment-Related Cancer;Trigeminal System;tumor;tumor microenvironment;tumor progression;tumorigenesis;Visualization;Xenograft procedure

PROJECT_TITLE: Sympathetic modulation of head and neck cancer pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Orphan Drug;Prevention;Prostate Cancer;Rare Diseases;Urologic Diseases;Women's Health Research

PI_NAMEs: FUQUA, SUZANNE AW (contact)

PROJECT_TERMS: Acceleration;Acute Myelocytic Leukemia;Address;Agonist;Androgen Receptor;apoAI regulatory protein-1;Area;Basic Science;Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Model;Cancer Prevention Intervention;carcinogenesis;Chromatin;Clinic;Clinical;Clinical assessments;Clinical Trials Design;Collaborations;college;Cytoskeleton;Defect;Dependence;Development;Direct Costs;Disclosure;Disease;Dysmyelopoietic Syndromes;Epigenetic Process;epigenetic regulation;Estrogen Receptors;Evaluation;experience;Funding;Genetic;Genetic Transcription;Glucocorticoid Receptor;Goals;Grant;hormone therapy;Human;Human Genetics;insight;inter-institutional;International;investigator-initiated trial;Link;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Medicine;member;men;Metastatic Prostate Cancer;MicroRNAs;Molecular and Cellular Biology;Molecular Genetics;Molecular Target;Mutation;Names;new therapeutic target;novel;novel therapeutics;Nuclear Receptors;Oncogenic;Pathogenesis;patient derived xenograft model;Peer Review;Pharmaceutical Preparations;Pharmacology;pre-clinical;Preclinical Testing;preventive intervention;Prognostic Marker;programs;prostate cancer metastasis;Publications;racial disparity;Regulation;Research;Research Personnel;Resistance;Role;RUNX1 gene;Scientific Advances and Accomplishments;Sertraline;Signal Transduction;small molecule;Tamoxifen;targeted treatment;Therapeutic;Therapeutic Intervention;Training;Transcriptional Regulation;Translational Research;Translations;treatment response;tumorigenesis;United States National Institutes of Health;Validation

PROJECT_TITLE: Nuclear Receptor, Transcription and Chromatin Biology Program


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Inflammation is a critical driver of coronary artery disease, the number one cause of death in the world. In this grant, we propose to develop, study, and clinically translate a catheter-based device that images coronary plaque microstructure and LUM015 near-infrared fluorescence, a new targeted fluorescent marker of inflammatory activity. Completion of this work will avail a powerful new clinical tool for evaluating and managing patients based on pathobiological information that accurately informs on coronary disease progression risk.

PI_NAMEs: JAFFER, FAROUC AMIN;TEARNEY, GUILLERMO J (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: acute coronary syndrome;advanced disease;Amendment;Animal Model;Apolipoprotein E;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Attenuated;Cardiac Catheterization Procedures;Carotid Endarterectomy;Cathepsins;Catheters;Cause of Death;Cells;Clinical;clinical imaging;Clinical Research;clinical translation;Coronary;Coronary Arteriosclerosis;Coronary artery;Coronary heart disease;coronary plaque;Coronary Thrombosis;design;detection platform;Development;Devices;Diagnosis;digital;Disease Management;dosage;Dose;drug development;Endothelium;Enzymes;Excision;Family suidae;Fiber;first-in-human;Fluorescence;Fluorescence Microscopy;follow-up;Grant;Hemorrhage;high resolution imaging;Histology;Hour;Human;Image;imaging agent;Imaging Device;imaging system;Imaging Techniques;Imaging technology;Immunohistochemistry;improved;in vivo;in vivo evaluation;individual patient;Inferior;Inflammation;Inflammatory;inflammatory marker;Injections;innovation;Intervention;Intravenous;intravital microscopy;Knowledge;Laboratories;Macrophage;Malignant Neoplasms;Mediating;Mediator;Methodology;Microanatomy;Molecular;Morbidity - disease rate;mortality;Multimodal Imaging;multimodality;Mus;Myocardial Infarction;Near-infrared optical imaging;novel;Operative Surgical Procedures;Optical Coherence Tomography;optical spectra;Oryctolagus cuniculus;Outcome;Oxidative Stress;Pathogenesis;Patients;Peptide Hydrolases;percutaneous coronary intervention;Pharmaceutical Preparations;pharmacologic;Play;pre-clinical;prevent;Process;progression risk;Randomized;Reporting;Reproducibility;Research;revascularization;Risk;RNA;Role;Safety;Saline;Severity of illness;Signal Transduction;Specimen;Stents;Structure;Subgroup;synergism;System;targeted agent;targeted imaging;Technology;Testing;Three-Dimensional Image;thrombogenesis;Time;tool;Transcript;Translating;Visualization;Work

PROJECT_TITLE: Clinical translation of targeted intracoronary imaging for inflammatory activity


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Infectious Diseases;Microbiome;Prevention;Rare Diseases

PI_NAMEs: ROSENBERG, SUSAN M (contact)

PROJECT_TERMS: Address;Aging;AIDS related cancer;anti-cancer research;Bacteria;Basic Science;Biochemistry;Bioinformatics;Biological;Biological Markers;Biology;biomarker identification;Cancer Center;Cancer Center Support Grant;cancer genome;Cancer Model;cancer prevention;Catchment Area;Cell Cycle Regulation;cell killing;Cell model;Cells;Chromosomes;Collaborations;college;Communicable Diseases;Communities;conventional therapy;Data;Detection;Diagnostic;diagnostic biomarker;Direct Costs;DNA biosynthesis;DNA Damage;DNA Repair;Epigenetic Process;epigenomics;Evolution;Flow Cytometry;Funding;Gene Expression;Genetic;Genetic Heterogeneity;Genetic Recombination;Genome;Genomic Imprinting;Genomics;Goals;gut inflammation;Heritability;Heterogeneity;Human;human data;Human Genetics;Human Genome;human model;imaging informatics;Immunology;Individual;inter-institutional;Interest Group;Intervention;Journals;Maintenance;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant Neoplasms;Manuscripts;Mediating;Medicine;meetings;member;Metabolic;metabolomics;Metagenomics;Methods;Microbe;Microbiology;microbiome;Microscopy;Mission;Modeling;Molecular;Molecular Biology;Molecular Genetics;Molecular Virology;mouse model;Mus;Mutagenesis;Mutation;new technology;non-genetic;novel;nutrition;Nutritional;Obesity associated disease;Organoids;Paper;Pathology;Patients;Pediatric Oncology;Peer Review;Phenotype;potential biomarker;programs;promoter;Proteins;Proteome;Proteomics;Publishing;recruit;Research;Research Personnel;Research Support;Resistance;Resource Sharing;Rice;Risk;RNA;Screening for cancer;single molecule;Structure;telomere;Texas;Therapeutic;therapeutic target;tool;Training;transcriptome;transcriptomics;tumorigenesis;United States National Institutes of Health;Universities;Variant;Viral;Virus;Work;Yeasts

PROJECT_TITLE: Mechanisms in Cancer Evolution Program


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

PI_NAMEs: ROSEN, JEFFREY MARK (contact)

PROJECT_TERMS: Achievement;advanced breast cancer;Animal Model;Basic Science;bone;Breast;breast cancer progression;Breast Cancer Treatment;cancer cell;Cancer Center;Cancer Center Support Grant;career development;Cell Line;Cell Therapy;Cellular Metabolic Process;chemotherapy;Clinic;Clinical;clinical practice;Clinical Trials;Collaborations;college;design;Development;diagnostic tool;Doctor of Philosophy;educational atmosphere;Endocrine;ERBB2 gene;Faculty;Funding;gene therapy;Genetically Engineered Mouse;Goals;Human;immune checkpoint blockade;Immune system;Immunocompetent;Immunotherapy;insight;inter-institutional;International;Journals;Laboratories;Malignant Breast Neoplasm;Malignant Neoplasms;mammary gland development;Manuscripts;Medical;Medicine;member;Micrometastasis;Modeling;Molecular;Myelogenous;Neoplasm Metastasis;new therapeutic target;novel;novel therapeutics;Pathway interactions;patient derived xenograft model;Patients;Peer Review;Postdoctoral Fellow;pre-clinical;Prevention;programs;Proteins;proteogenomics;Publishing;recruit;Recurrence;Regimen;Research;Research Personnel;Resistance;resistance mechanism;response;RNA Splicing;Role;Signal Pathway;Signal Transduction;small molecule therapeutics;Specialized Program of Research Excellence;standard of care;stem cells;Students;targeted treatment;Testing;therapy resistant;Translating;Translations;treatment response;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;tumor progression

PROJECT_TITLE: Breast Cancer Program


ADMINISTERING_IC: GM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative This grant application will evaluate a novel role of the antioxidant protein peroxiredoxin 6 in the regulation of cellular respiration and a new non-apoptotic cell death pathway. The results of this effort will increase our understanding of basic biochemical pathways that underlie cellular homeostasis and are dysregulated in several pathophysiological conditions.

PI_NAMEs: VAZQUEZ MEDINA, JOSE P (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acute Lung Injury;Acylation;Acyltransferase;Affect;analytical tool;Antioxidants;Applications Grants;Biochemical Pathway;Biological Assay;Biology;carcinogenesis;Catalytic Domain;Cell Death;cell growth regulation;Cell membrane;Cell Respiration;Cells;Central Nervous System Diseases;Chronic;Cystine;Data;Degenerative Disorder;Disease;Enzymes;Equilibrium;extracellular;Future;Gene Expression Profile;glutathione peroxidase;Homeostasis;Hydrogen Peroxide;Hypoxia;Imaging Techniques;Inflammation;interest;Iron;Ischemia;Lysophosphatidylcholines;Maintenance;Male Infertility;Mediator;Mitochondria;mitochondrial metabolism;Morphology;Mus;Muscular Atrophy;Non-Insulin-Dependent Diabetes Mellitus;novel;Oxidation-Reduction;oxygen toxicity;Pathway interactions;peroxiredoxin;Phospholipase A2;Phospholipids;Physiological;Point Mutation;Prevention strategy;Proteins;Regulation;repair enzyme;Reperfusion Injury;Respiration;Retinal Diseases;Role;Stroke;Three-Dimensional Imaging;translational approach;Traumatic Brain Injury;uptake

PROJECT_TITLE: The Biology of Peroxiredoxin 6

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Streptococcus mutans is an oral bacterium and major global infectious agent that causes human dental caries, as well as bacterial endocarditis and atherosclerosis, with annual health care costs related to dental caries in the US alone exceeding 64 billion dollars. Multiple virulence properties of S. mutans stem from the way the organism inserts proteins into the lipid bilayer of the membrane, but the cellular machinery that transports these proteins is not completely understood. This research explains how proteins important for disease get into the membrane of S. mutans and other related pathogens.

PI_NAMEs: BRADY, L. JEANNINE  (contact);MISHRA, SURABHI

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Address;Amino Acids;Atherosclerosis;Bacteria;Bacterial Endocarditis;Binding;Binding Proteins;Biological;Biological Assay;cardiolipin synthase;Cardiolipins;Carrier Proteins;Cell membrane;Cell Physiology;Cells;Cellular Membrane;Charge;Chloroplasts;Circular Dichroism;Codon Nucleotides;Complex;Coronary;Coupled;Dental;Dental caries;design;Destinations;Disease;Drug Targeting;Endoplasmic Reticulum;Environment;Epithelial Cells;Epitopes;Escherichia coli;Etiology;Evaluation;Exhibits;extracellular;Family;Freedom;Funding;gain of function mutation;Genes;Genetic Transcription;Genomics;Grain;Grant;Growth;Health Care Costs;Housekeeping;Human;Impairment;in silico;In Vitro;in vivo;Individual;Infectious Agent;Inner mitochondrial membrane;interest;Interferometry;Invaded;Learning;Lipid Bilayers;lipid biosynthesis;lipidome;lipidomics;Lipids;Liposomes;Mass Spectrum Analysis;Mediating;Membrane;Membrane Lipids;Membrane Proteins;Messenger RNA;Mitochondria;mitochondrial membrane;Molecular Chaperones;Molecular Conformation;molecular dynamics;mRNA Stability;mRNA Transcript Degradation;mutant;NMR Spectroscopy;Operon;oral bacteria;oral pathogen;Organelles;Organism;pathogen;Pathway interactions;Permeability;Phenotype;Phospholipids;Play;Polyacrylamide Gel Electrophoresis;Post-Transcriptional Regulation;posttranscriptional;Preparation;Process;Property;protein complex;Protein Family;protein protein interaction;protein structure;Protein translocation;protein transport;Proteins;proteoliposomes;Proteomics;reconstitution;Recurrence;Reporter;Research;Ribonucleoproteins;Ribosomes;RNA-Binding Proteins;RNase P;Role;Shapes;Signal Recognition Particle;Site-Directed Mutagenesis;solid state nuclear magnetic resonance;spatial integration;stem;Streptococcus mutans;Stress;stress tolerance;Structure;Study models;System;targeted treatment;transcriptome sequencing;Translations;Transmembrane Domain;Vesicle;Virulence;Western Blotting;Work

PROJECT_TITLE: MEMBRANES OF THE DENTAL PATHOGEN STREPTOCOCCUS MUTANS

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: HESLOP, HELEN E (contact)

PROJECT_TERMS: Address;Adoptive Immunotherapy;Adult;antiviral immunity;Basic Science;bench to bedside;cancer cell;Cancer Center;Cancer Center Support Grant;cancer immunotherapy;cancer stem cell;cancer therapy;Cell Therapy;cell type;Cells;Cellular biology;Cellular Immunity;Characteristics;Childhood;Clinical;clinical implementation;Clinical Research;clinical translation;Clinical Trials;Collaborations;college;Cytotoxic T-Lymphocytes;Development;Doctor of Philosophy;Ensure;first-in-human;Funding;Gene Modified;gene therapy;Goals;Good Manufacturing Process;Graft-Versus-Tumor Induction;Grant;Head and neck structure;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Hodgkin Disease;Hospitals;Human Genetics;Immune;Immune system;Immunology;Immunotherapy;improved outcome;Industrialization;Industry;Institution;Journals;Laboratories;Laboratory Study;Licensure;Liver diseases;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant neoplasm of nasopharynx;Malignant Neoplasms;manufacturing facility;Manuscripts;Medicine;member;Methodist Church;Mission;Molecular;Molecular Biology;Molecular Genetics;Neck Disorder;Neuroblastoma;Neurosciences;neurosurgery;novel therapeutic intervention;Operative Surgical Procedures;Pancreatic Diseases;Pathology;Pediatric Hospitals;Pediatrics;Peer Review;Phase;post-transplant;predicting response;Production;programs;Protocols documentation;Publications;Publishing;Reagent;reconstitution;Recording of previous events;Reporting;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Running;Scientist;Series;stem cell biology;stem cell growth;Stem cell transplant;stem cells;success;Systems Analysis;T-Cell Lymphoma;T-Lymphocyte;Testing;Texas;Translational Research;translational scientist;Translations;Transplantation;tumor;Tumor Antigens;vector;Virus;virus related cancer;Work

PROJECT_TITLE: Cancer Cell and Gene Therapy


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

PI_NAMEs: BADR, HODA J. (contact)

PROJECT_TERMS: Address;Adult;Affect;Area;Behavior Therapy;Behavioral;Behavioral Sciences;Biological Sciences;biomedical informatics;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Etiology;cancer health disparity;Cancer Patient;cancer prevention;cancer risk;Cancer Survivor;Catchment Area;Child;Childhood;Clinical;Clinical Sciences;Collaborations;college;Communication;Communities;community engagement;Community Outreach;Computer Models;Data;data modeling;Data Sources;Discipline;Disease;Early Diagnosis;Environmental Exposure;Epidemiology;Etiology;Family;Funding;gene environment interaction;Genetic;Genetic study;Goals;Health Services Research;high risk;high risk population;Home;improved;Incidence;Individual;individualized prevention;Infectious Agent;innovation;inter-institutional;interest;International;Intervention;Intervention Studies;Journals;Leadership;Malignant - descriptor;Malignant Neoplasms;Measures;Medicine;member;Methods;metropolitan;Mission;Modeling;Morbidity - disease rate;mortality;multidisciplinary;next generation;novel;Obesity;Observational Study;Operative Surgical Procedures;Outcome;Outcomes Research;Paper;Patient risk;Patient-Focused Outcomes;Patients;Peer Review;Persons;Population Sciences;Population Study;pre-clinical;predictive tools;Prevention Research;preventive intervention;Primary Prevention;prognostic;programs;Publications;Publishing;recruit;Rehabilitation therapy;Research;Research Contracts;Research Personnel;Research Priority;Research Project Grants;Resolution;Resources;Risk;Risk Assessment;Risk Factors;risk prediction model;Risk Reduction;Science;Scientific Inquiry;Scientist;screening;Second Primary Cancers;secondary outcome;Secondary Prevention;Statistical Methods;Strategic Planning;symptom management;Texas;Tobacco;Training;Translational Research;Underserved Population;Variant;Virus;Work;working group;young adult

PROJECT_TITLE: Cancer Prevention and Population Sciences


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

PI_NAMEs: BLANEY, SUSAN M. (contact)

PROJECT_TERMS: Acute;Address;Adolescent;Africa South of the Sahara;African;anti-cancer research;Basic Science;Biological;Budgets;cancer cell;Cancer Center;Cancer Center Support Grant;cancer diagnosis;cancer genetics;cancer genomics;cancer prevention;Cancer Survivorship;Caregivers;Catchment Area;Child;Childhood;Childhood Solid Neoplasm;Cities;Clinical;Clinical Research;clinical trial enrollment;Clinical Trials;Collaborations;college;Confusion;Country;County;Coupled;demographics;Developmental Therapeutics Program;Diagnostic;Disease;Early Diagnosis;early phase clinical trial;Education;Enrollment;ethnic diversity;Funding;gene therapy;Genetic;genomic tools;Genomics;Goals;Hematology;Histiocytosis;improved;improved outcome;Inequity;Infrastructure;innovation;inter-institutional;International;Investigation;Journals;Laboratories;leukemia;Lymphoma;Malignant Childhood Neoplasm;Malignant Neoplasms;Manuscripts;Medicine;member;Mexico;Mission;Molecular;Nature;neuro-oncology;neurosurgery;Nurses;Oncology;Operative Surgical Procedures;Pathology;Pediatric Hematology;Pediatric Hospitals;Pediatric Neoplasm;Pediatric Oncology;Pediatrics;Peer Review;Physicians;Population Heterogeneity;Population Sciences;Population Study;Positioning Attribute;Productivity;prognostic;Program Description;programs;Proteomics;Psychology;racial diversity;Radiology Specialty;Research;Research Personnel;Research Support;Resource Sharing;Risk;Scientific Advances and Accomplishments;side effect;Site;Texas;Therapeutic;Therapeutic Studies;Time;Toxic effect;Training;Training Programs;Translational Research;Treatment outcome;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Pediatric Cancer Program


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: Project Narrative A pressing challenge in the treatment of retinal diseases is to restore vision in retina with irreversible photoreceptor degeneration. This project aims at developing a novel gene therapy strategy for vision restoration – using virally expressed phototransduction components in retinal ganglion cells to enhance the light sensitivity and response kinetics of melanopsin. The objectives of this project will have a significant impact on treating blindness and vision loss by providing a knowledge base for future improvement of vision restoration therapy.

PI_NAMEs: JIANG, ZHENG  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Acceleration;activity marker;Animals;behavior test;Blindness;Brain;Cell Death;Cells;Cyclic Nucleotides;cyclic-nucleotide gated ion channels;Data;Death Rate;density;Dominant-Negative Mutation;Effectiveness;Endowment;Family;FOS gene;Future;G-Protein-Coupled Receptors;gene therapy;Image;immunocytochemistry;improved;Inflammatory Response;innovation;Ion Channel;Kinetics;Knowledge;knowledge base;Light;light intensity;Measures;Mediating;melanopsin;member;Modality;Modification;Monitor;mouse model;multi-electrode arrays;Mus;mutant;Names;neural;novel;optogenetics;overexpression;patch clamp;Pathway interactions;Pattern;PDE4A4;Phase;photoactivation;Photophobia;photoreceptor degeneration;Photoreceptors;Phototransduction;Proteins;response;restoration;Retina;Retinal Diseases;Retinal Ganglion Cells;retinal neuron;Reverse Transcriptase Polymerase Chain Reaction;Rhodopsin;sight restoration;Signal Pathway;Signal Transduction;Signaling Molecule;Speed;temporal measurement;Testing;theories;Therapeutic;Transfection;treatment strategy;trend;Vertebrate Photoreceptors;Viral;Vision;vision aid;Visual;Water;Work

PROJECT_TITLE: A new strategy for vision restoration based on melanopsin transduction mechanisms

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE We propose to elucidate components of transcription complex and mechanisms of RNA synthesis in mitochondrion of Trypanosoma brucei. Kinetoplast DNA, a taxonomic class-defining feature of this parasite, has been targeted by therapeutics albeit with limited success. Therefore, a better fundamental understanding of an essential kinetoplast DNA-based molecular mechanism, such as transcription, may facilitate development of drugs against hemoflagellate-borne infections.

PI_NAMEs: AFASIZHEV, RUSLAN  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Affect;Affinity Chromatography;Africa South of the Sahara;African;Animals;Area;Biological;Biotinylation;Blood Circulation;Chemicals;Code;Complex;crosslink;Data;Developing Countries;Development;Disease;DNA;DNA biosynthesis;DNA-Directed RNA Polymerase;drug development;Drug Targeting;Economic Burden;Elements;endonuclease;Eukaryota;Evolution;Excision;experimental study;Family;fascinate;Foundations;fungus;Gene Expression;Gene Proteins;Genes;Genetic Transcription;Genome;genome-wide;Guide RNA;hemoflagellate;Histones;Human;In Vitro;in vivo;Individual;Infection;innovation;Insecta;insight;Kinetoplast DNA;Link;Location;Maps;Mass Spectrum Analysis;Messenger RNA;Mitochondria;Mitochondrial DNA;mitochondrial genome;Mitochondrial RNA;Modeling;Molecular;mRNA Precursor;mRNA Transcript Degradation;Mutation;Nucleoproteins;Organism;Parasites;particle;Pathogenesis;Phosphorylation;Polyadenylation;Polymerase;Population;Positioning Attribute;posttranscriptional;Proliferating;promoter;Promoter Regions;protein protein interaction;Proteins;Public Health;Recombinants;reconstitution;Relaxation;Research;Resources;respiratory;Ribosomal Proteins;Ribosomal RNA;RNA;RNA chemical synthesis;RNA Editing;RNA Processing;Role;Shapes;Site;success;superresolution microscopy;System;targeted treatment;TATA Box;Taxonomy;tool;Transcript;transcription factor;Transcription Initiation;Transcription Initiation Site;Transcriptional Regulation;Transfer RNA;Trypanosoma;Trypanosoma brucei brucei;Trypanosomiasis;Untranslated RNA;virtual

PROJECT_TITLE: TRANSCRIPTIONAL CONTROL OF MITOCHONDRIAL GENE EXPRESSION IN TRYPANOSOMES

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)]


NIH_SPENDING_CATS: Cancer;Immunotherapy

PROJECT_TERMS: Address;Animal Cancer Model;Area;Award;Budgets;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Model;Catchment Area;clinical investigation;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;college;Comprehensive Cancer Center;Core Facility;Development;Disease;Effectiveness;Emerging Technologies;Evolution;Fostering;Funding;Gene Modified;Goals;Grant;Immune checkpoint inhibitor;Immunotherapy;in vivo;innovation;Institution;investigator-initiated trial;Investments;Malignant Neoplasms;Medicine;member;microbiome signature;Monitor;NCI Center for Cancer Research;Nursing Faculty;patient derived xenograft model;Patients;Phase;Pilot Projects;programs;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;response;Strategic Planning;success;Surveys;T-Lymphocyte;Technology;Time;Toxic effect;working group

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences;Prevention;Stroke

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE To date, there are no effective treatments for improving blood flow and preventing fat deposition in the injured heart muscle after a heart attack, despite tremendous research efforts in the field. Our goal is to use a novel noninvasive imaging method that will provide reproducible and accurate assessment of the blood flow and fat accumulation within injured muscle after treatment with antiallergic medications.

PI_NAMEs: COKIC, IVAN ;LI, DEBIAO  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Acute;Acute myocardial infarction;Adipose tissue;Aftercare;Aging;Animal Model;Anti-Allergic Agents;Arteries;artery occlusion;Atherosclerosis;Attenuated;Biological Markers;Blood flow;Blood Vessels;blood-brain barrier permeabilization;Cardiac;Cardiovascular system;Cause of Death;Cell Degranulation;Cerebral hemisphere hemorrhage;Cerebral Ischemia;Chronic;Chronic Phase;Cicatrix;Clinical;Clinical Management;Coculture Techniques;Collagen;Compensation;Cytoplasmic Granules;Deposition;Development;disability;Early treatment;Edema;effective therapy;effectiveness evaluation;effectiveness validation;Event;experimental study;Fatty acid glycerol esters;Foam Cells;Gadolinium;Goals;Growth;Heart failure;Heart Injuries;Hematoma;Hematopoietic stem cells;Hemorrhage;Histamine;Hypersensitivity;imaging biomarker;imaging modality;improved;in vivo;Infarction;Inflammation;injured;Injury;Intervention;Iron;Longitudinal Studies;Loratadine;Low-Density Lipoproteins;Macrophage;Magnetic Resonance;Magnetic Resonance Imaging;Maps;mast cell;Mast Cell Stabilizer;Mediator;Metaplasia;Microcirculation;Muscle;Myocardial;Myocardial Infarction;myocardial injury;Myocardial Ischemia;Myocardial Reperfusion;Myocardial tissue;Myocardium;Nervous System Trauma;non-invasive imaging;novel;novel therapeutic intervention;Obstruction;Outcome;Pathologic;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Phase;Phenotype;Physiological;Pilot Projects;porcine model;prevent;Prevention strategy;Proteoglycan;Reperfusion Therapy;Reporting;Reproducibility;Research;response;Role;Techniques;therapeutically effective;thrombotic;Tissues;uptake;Validation;Ventricular Remodeling

PROJECT_TITLE: Assessment of Mast Cell Degranulation in Infarcted Myocardium Using Quantitative Multiparametric MRI

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: Advisory Committees;Area;authority;Basic Science;Cancer Center;Cancer Center Support Grant;Catchment Area;Cell Therapy;Clinical;clinical care;Clinical Research;Clinical Sciences;Collaborations;college;Communication;Communities;Community Outreach;Complement;Decision Making;Department chair;Development;Disease;Education;Education and Outreach;Ensure;Evaluation;Faculty;Feedback;Funding;Goals;Group Meetings;Immunooncology;Investigational Therapies;Investments;Leadership;Malignant Neoplasms;Medicine;meetings;member;Mission;Monitor;NCI-Designated Cancer Center;Obesity;Phase;Population;Population Sciences;precision medicine;Process;Program Evaluation;Program Reviews;programs;recruit;Reporting;Research;Research Personnel;Resource Sharing;Source;Strategic Planning;Structure;Time;Translational Research;Vision;Work;working group

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

PI_NAMEs: ROUCE, RAYNE HELEN (contact)

PROJECT_TERMS: Address;Advocacy;Affect;African American population;AIDS related cancer;anti-cancer research;Area;Award;Awareness;Behavioral;Breast;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer health disparity;cancer prevention;cancer risk;Catchment Area;Cervical Cancer Screening;Cervix Uteri;Charge;Cities;Collaborations;college;Colon;Colorectal;colorectal cancer screening;Communication;Communities;community advisory board;community engaged research;community engagement;Community Outreach;community partners;Comprehensive Cancer Center;County;Data;Death Rate;Development;Disease;Disparity;Education;education resources;ethnic minority population;Evidence based intervention;Exhibits;Funding;Geographic Information Systems;Geographic Locations;Goals;Grant;health disparity;Health system;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;improved;Incidence;Individual;innovation;Lead;Linguistics;Liver;long-standing disparities;Lung;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;medically underserved;medically underserved population;Medicine;Methods;metropolitan;Minority Groups;Modeling;Monitor;NCI Center for Cancer Research;neoplasm registry;Obesity;outreach;outreach program;patient navigation;patient oriented;Pediatric Hospitals;Policies;Population;Population Heterogeneity;Population Sciences;prevent;Prevention;Prevention program;Prevention strategy;Primary Prevention;programs;Prostate;racial minority population;Research;Research Institute;Risk Factors;safety net;screening;Screening for cancer;screening program;SEER Program;standard of care;success;Support Groups;survivorship;System;Texas;Time;Translational Research;underserved minority;Uninsured;United States National Institutes of Health;Work;working group

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Digestive Diseases;Food Allergies;Microbiome;Nutrition;Pediatric;Prevention

PHR: Project Narrative Using a mouse model and human milk, we recently discovered that breast milk from mothers who mounted protective immune responses to food, induces regulatory T immune cells that mediate tolerance in children and protect them from food allergy, a global health problem that affects 8% of children and 5% of adults in the U.S. In this proposal, we aim to find how maternal tolerance-promoting bacteria in breast milk induce offspring regulatory T cells to establish tolerance to food in children early in life, and how they are modulated by genetic mutation linked to atopy. Our studies will support potential beneficial effects of breastfeeding on protecting babies from food allergy, and will define how genetic factors affect tolerance induction in neonates, paving the way towards the design of effective therapies and prevention strategies for food allergy.

PI_NAMEs: OYOSHI, MICHIKO  (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Adult;Affect;Alleles;Allergens;Allergic;allergic response;Anaphylaxis;Animal Model;Antibiotics;Antibodies;Antigen-Antibody Complex;atopy;Bacteria;bacterial community;Basophils;Breast Feeding;CD4 Positive T Lymphocytes;Cell Differentiation process;Cells;Child;Chymase;comparison control;Data;design;DNA Sequence Alteration;effective therapy;experimental study;Failure;Fc Receptor;Food;food allergen;Food Hypersensitivity;Fostering;Frequencies;gain of function mutation;Genes;Genetic;Genotype;Germ-Free;global health;Goals;gut microbiota;Human;Human Milk;human milk oligosaccharides;IgE;Immune;Immune response;Immunoglobulin G;Impairment;in vivo;Infant Food;innovation;Interleukin 4 Receptor;Intestines;Investigation;ITGAX gene;Lactation;lactation period;Life;Link;mast cell;maternal microbiota;Mediating;Mediator;microbiota;Milk;Mothers;mouse model;Mus;Neonatal;neonatal Fc receptor;neonate;offspring;Oral;Orphan;Ovalbumin;Pathway interactions;Pilot Projects;Population;Predisposition;prevent;Prevention strategy;Preventive;Process;Proteins;Public Health;receptor;Regulatory T-Lymphocyte;response;Retinoic Acid Receptor;Role;Serum;Shapes;Signal Transduction;Skin;Supplementation;tool;Weaning;Wild Type Mouse;Work

PROJECT_TITLE: Maternal influence on offspring food allergy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-K(57)]


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: MIMS, MARTHA P (contact)

PROJECT_TERMS: Agreement;Ambulatory Care;Amendment;Award;Budgets;Cancer Center;Cancer Center Support Grant;Catchment Area;Child;Clinical;Clinical Data;clinical development;Clinical Investigator;Clinical Management;Clinical Protocols;Clinical Research;Clinical Trials;Clinical Trials Support Unit;college;Comprehensive Cancer Center;Data;data management;Databases;Disease;Electronics;Ensure;Event;experience;Hospitals;Human Resources;Individual;Informatics;Institutional Review Boards;Intervention Trial;Maintenance;Malignant Neoplasms;Mediation;Medicine;member;Minority;Monitor;Nurses;Nursing Research;older adult;operation;Outcome;participant safety;patient registry;patient safety;Patients;Preparation;programs;Protocols documentation;quality assurance;Quality Control;Regulatory Affairs;Reporting;Research;Research Personnel;research study;Research Support;Risk;Safety;Services;Training;Training and Education;Woman;Work;working group

PROJECT_TITLE: Clinical, Protocol and Data Management


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Cancer;Complementary and Integrative Health;Immunotherapy;Natural Products;Skin Cancer

ORG_CITY: LA JOLLA

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative In this project, Drs. Lu and Fenical aim to collaborate in the discovery of new drugs that enhance the immune system to more effectively combat cancer. The researchers will focus their discovery effort on new drug candidates found in the ocean’s microorganisms, a resource never examined for natural drugs. Their approach involves testing marine natural products for their ability to bind to a specific protein, called PD-1 that is involved in the human immune system in combating the onset of cancer.

PI_NAMEs: FENICAL, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: antagonist;Antibodies;Antineoplastic Agents;Aquaculture;Bacteria;Binding;Binding Proteins;Biological Assay;Biomedical Research;Buffers;Calorimetry;Cancer Biology;cancer immunotherapy;Cell Line;Cell Survival;Cells;chemical resource;Chemicals;China;Chinese Hamster Ovary Cell;Chinese Traditional Medicine;Collaborations;Collection;combat;Complex;Component of the National Cancer Institute;deep ocean;Development;Dimethyl Sulfoxide;drug candidate;Drug Costs;Dyes;effective therapy;Evaluation;experimental study;Fermentation;fungus;Goals;Human;Immune checkpoint inhibitor;Immune system;Immunoprecipitation;Immunotherapy;improved;In Vitro;inhibitor;Institution;instrumentation;Interferometry;Kinetics;large scale production;Lymphocyte;Lymphocyte Activation;Malignant Neoplasms;marine;marine natural product;Measurement;Measures;Melanoma;Melanoma Cell;melting;microbial;Microbial natural product;microorganism;milligram;Modeling;Molecular;mouse model;Mus;Natural Products;novel therapeutics;Oceanography;Oceans;PD-1 inhibitors;PD-1/PD-L1;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Pharmacy Schools;professor;programmed cell death ligand 1;programmed cell death protein 1;programs;Promega;Proteins;Protocols documentation;Rattus;Research Personnel;Resources;response;Sampling;screening;small molecule;small molecule therapeutics;Solid;Source;Spectrometry, Mass, Electrospray Ionization;Structure;System;T-Cell Activation;T-Lymphocyte;Techniques;Testing;Time;Titrations;Treatment Efficacy;tumor growth;United States National Institutes of Health;Universities;Validation;Yin

PROJECT_TITLE: Discovery of PD-1/PDL-1 inhibitors from marine microbial natural products

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-N(50)R]


NIH_SPENDING_CATS: Cancer;Patient Safety;Prevention

PI_NAMEs: BERG, STACEY L (contact)

PROJECT_TERMS: Amendment;authority;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Intervention;cancer prevention;cancer research center director;Cancer Therapy Evaluation Program;Cell Therapy;Clinic;Clinical;Clinical Cancer Center;Clinical Protocols;Clinical Research Protocols;Clinical Trials;college;Comprehensive Cancer Center;Concept Review;Conduct Clinical Trials;Data;Descriptor;Development;Diagnostic Trial;Eligibility Determination;epidemiology study;expedited review;Funding;Funding Mechanisms;gene therapy;Goals;group intervention;Health system;Hospitals;Industry;Institution;Institutional Review Boards;Intervention;Lead;Malignant Neoplasms;Medical center;Medicine;member;Methodist Church;Monitor;Observational Study;Pediatric Hospitals;Peer Review;Policies;Prevention;Process;programs;Protocols documentation;Research;Research Personnel;Review Committee;Safety;Site;Supportive care;System;Texas;Time;United States National Institutes of Health;working group

PROJECT_TITLE: Protocol Review and Monitoring System


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE  Cardiovascular disease (CVD) remains the top cause of death in the U.S., and diet is the leading contributing factor to developing CVD. Racial, ethnic, and socioeconomically disadvantaged groups, who disproportionately rely on federal safety-net programs like the Supplemental Nutrition Assistance Program (SNAP) and Medicaid, are at higher risk for both poor diet and CVD. This proposed research will provide needed evidence about the diet and health of individuals receiving SNAP, and how SNAP intersects with CVD outcomes – which will help inform clinicians and policymakers on ways to better ensure high-quality, equitable nutrition that can prevent negative cardiovascular and other health outcomes among racial, ethnic, and socioeconomically disadvantaged Americans.

PI_NAMEs: BRANDT, ERIC J (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, ANGELA R

PROJECT_TERMS: Accounting;Acute;advanced analytics;American;beneficiary;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;career development;Caring;Cause of Death;Cessation of life;Clinical;Data;Data Collection;Data Set;Development Plans;Diet;Dietary Practices;disease disparity;Disease Outcome;Disparity population;Drug Prescriptions;early-career faculty;Economically Deprived Population;Educational process of instructing;Educational workshop;Eligibility Determination;Enrollment;Ensure;Environment;Equity;ethnic minority population;Ethnic Origin;Ethnic Population;Event;experience;Face;Financial Hardship;Food;food insecurity;Frequencies;Goals;Health;health disparity;health equity;Health Services;Health Services Research;high risk;Hospitalization;improved;improved outcome;Income;Individual;inpatient service;Interview;Knowledge;lens;Link;Low income;Low Income Population;Manuscripts;Mediating;Medicaid;Medical;Medical Care Costs;medication compliance;meetings;Mentorship;Methods;Michigan;minority health disparity;mortality;National Health and Nutrition Examination Survey;novel;nutrition;Nutrition Policy;nutritional epidemiology;Outcome;outpatient programs;Participant;Patients;Pattern;Pharmaceutical Services;Policies;Policy Maker;Poverty;premature;prevent;Preventive;Principal Component Analysis;programs;prospective;Publications;Qualitative Methods;Race;racial minority;racial minority population;racial population;Reduce health disparities;Reporting;Research;Research Personnel;Resource Development;Risk Factors;safety net;Security;Services;skills;social health determinants;Social Work;socioeconomic disadvantage;Structure;Testing;Training;Unhealthy Diet;Universities;Work

PROJECT_TITLE: Cardiovascular outcomes related to nutrition policies among socioeconomically disadvantaged populations


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Despite widespread implementation of prevention of mother-to-child transmission of HIV (PMTCT) programs in sub-Saharan Africa, many HIV-affected mother-infant dyads do not realize the full benefits of these services, resulting in unnecessary morbidity and mortality. Mentor Mothers are peer advocates who support HIV-affected mothers-infant dyads as they navigate PMTCT services, but the current “one size fits all” approach lacks responsiveness to the fact that some dyads need minimal support while others have specific needs. This proposal aims to promote optimal PMTCT outcomes through a person-centered approach to the development of an enhanced Mentor Mother strategy that focuses on both the specific problems faced by unique HIV- affected mothers-infant dyads, as well as the real-world constraints of PMTCT programs in resource- constrained settings.

PI_NAMEs: CARLUCCI, JAMES G (contact)

PROGRAM_OFFICER_NAME: DEYAMPERT, TARA LYNN

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Advocate;Affect;Africa South of the Sahara;Age Months;career development;Caring;Cessation of life;Child;Clinic;Data;design;Development;Diagnostic;Educational workshop;Effectiveness;effectiveness/implementation study;Event;experience;follow-up;Funding;Future;Goals;Health;health care availability;HIV;HIV Infections;Human immunodeficiency virus test;Hybrids;implementation fidelity;implementation science;improved;Infant;Intervention;Interview;Kenya;Knowledge;Lactation;Leadership;low and middle-income countries;Maternal and Child Health;Mentors;Mentorship;Meta-Analysis;Methods;Modeling;Morbidity - disease rate;mortality;Mother-to-child HIV transmission;Mothers;Outcome;Outcome Measure;peer;Perception;person centered;Physicians;pregnant;prevent;Prevention;Productivity;programs;randomized, clinical trials;Research;research and development;Research Infrastructure;Research Methodology;Research Personnel;Resource-limited setting;risk minimization;Scientist;Services;skills;Targeted Research;Testing;Vertical Disease Transmission;Vertical Transmission;Viral;Viremia;Woman

PROJECT_TITLE: Developing an enhanced Mentor Mother strategy to improve prevention of mother-to-child transmission of HIV (PMTCT) outcomes


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Data Science;Genetics;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Malaria;Malaria Vaccine;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE Plasmodium falciparum, the most common species of malaria, kills more children than any other pathogen, and the development of a highly effective vaccine has been challenging. Children acquire immunity to malaria with repeated exposure, but the mechanism is poorly understood. We will collect samples from children who are exposed to Plasmodium-infected mosquito bites and compare the immune responses among those who develop infection to those who do not to identify possible targets for vaccines to prevent malaria infection.

PI_NAMEs: FRIEDMAN-KLABANOFF, DEANNA  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: acquired immunity;Alleles;Anopheles Genus;Antibodies;Antibody titer measurement;Antigens;B-Lymphocytes;Berry;Binding;Biological Assay;Bite;Blood;career;career development;Child;Childhood;Circulation;Classification;Clinical;Clinical Immunology;Clinical Research;Cohort Studies;Collection;Communicable Diseases;Culicidae;Custom;Data;Data Science;Databases;Dedications;design;Detection;Development;Development Plans;Disease;DNA;Doctor of Medicine;epidemiology study;Epitopes;Erythrocytes;Exposure to;Funding;Generations;Genetic Variation;Geographic Locations;global health;Goals;Household;Human;human DNA;Humoral Immunities;Immune;Immune Evasion;Immune response;Immune system;Immunity;Immunodominant Epitopes;Immunology;Impairment;improved;in silico;In Vitro;in vitro Model;in vivo;Individual;Infection;insight;interest;International;Invaded;K-Series Research Career Programs;Laboratories;large datasets;Leadership;Life Cycle Stages;Liver;machine learning algorithm;Malaria;malaria infection;malaria mosquito;Malaria Vaccines;Malawi;Maryland;medical schools;member;Membrane Proteins;Mentors;Mentorship;Methods;Microarray Analysis;Microsatellite Repeats;Modeling;Molecular Epidemiology;Natural Immunity;novel;novel vaccines;Outcome;Parasites;participant enrollment;pathogen;Peptides;Plasmodium;Plasmodium falciparum;Plasmodium falciparum genome;polyclonal antibody;Positioning Attribute;predictive tools;prevent;Proteins;random forest;Research;Research Design;Research Personnel;response;Role;Salivary Glands;Sampling;serological marker;Serology;Serum;skills;Source;Specialist;Sporozoites;surveillance data;T-Lymphocyte Epitopes;Testing;tool;Training;translational scientist;transmission process;Travel;United States National Institutes of Health;Universities;vaccine candidate;vaccine development;Vaccines;vaccinology;Variant;Work

PROJECT_TITLE: Serological markers of natural immunity to Plasmodium falciparum infection


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Mental Health;Neurosciences;Pediatric;Prevention;Sleep Research;Substance Misuse;Underage Drinking

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Heavy alcohol drinking during adolescence is known to disturb brain development and functioning and increase risk of drinking problems in adulthood, but the extent of the lingering effects of youthful drinking on adult functioning remains unclear. The goal of NCANDA-A (Adulthood) is to follow youth who had remained no-to-low drinkers compared with those who had engaged in hazardous drinking to determine alcohol's influence on cognitive, emotional, and life activities in emerging adulthood when young men and women are establishing themselves in careers, relationships, and independent living. Recognition of signs of risk to adjustment in adulthood following youthful drinking may enhance opportunity for personal success.

PI_NAMEs: BROWN, SANDRA A;TAPERT, SUSAN F (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: 21 year old;Acceleration;Acute;addiction;Address;Adolescence;Adolescent;Adolescent and Young Adult;Adult;Affect;Age;Alcohol abuse;Alcohol consumption;alcohol cue;alcohol effect;alcohol use disorder;alcohol use initiation;Alcohols;Authorship;Behavior;Behavioral;binge drinking;Biological;Brain;career;career development;Career Mobility;Clinical;Cognition;Cognitive;cognitive performance;cohort;Communication;Communities;Computers;Conflict (Psychology);COVID-19 pandemic effects;cue reactivity;Data;Data Analyses;Data Collection;data standards;design;Development;Disputes;drinking;Economics;Elements;emerging adult;emerging adulthood;Emotional;Ensure;Evaluation;Female;follow-up;Functional Magnetic Resonance Imaging;Gender;Goals;gray matter;Growth;hazardous drinking;Health Sciences;heart function;Heart Rate;Heavy Drinking;Home;improved;Independent Living;Individual;International;Interview;Leadership;Learning;Life;Link;longitudinal design;Magnetic Resonance Imaging;male;Measures;medical specialties;meetings;Memory;Mission;mobile application;Modeling;modifiable risk;Monitor;multimodal neuroimaging;National Institute on Alcohol Abuse and Alcoholism;neural;neurodevelopment;neuroimaging;novel;Oregon;Outcome;Patient Recruitments;Pattern;Performance;Personal Satisfaction;Persons;Physical activity;Policies;Positioning Attribute;post-pandemic;pre-pandemic;Procedures;Process;programs;prospective;Protocols documentation;Psychopathology;Recovery;Reporting;Research;Research Project Grants;Resolution;Resources;response;Rest;retention rate;Risk;Risk Factors;Sampling;Schools;Science;Sex Differences;Site;Site Visit;Sleep;Sleep disturbances;social;Standardization;Stress;Structure;success;Symptoms;System;Technology;Testing;Training;Trust;underage drinking;Universities;Vision;Work;young adult;young man;young woman;Youth

PROJECT_TITLE: National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA): Administrative Resource


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Infectious Diseases;Microbiome;Nutrition;Prevention

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative Intestinal infection is a significant health burden worldwide. The goals of this proposal are to decipher how nutrients change host resistance against infection, and how resident bacteria influence this dietary regulation. Understanding these mechanisms will direct new approaches for developing diet- and microbiota- based interventions to prevent and treat infection.

PI_NAMEs: HASHIMOTO-HILL, SEIKA  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Address;anti-microbial peptide;Bacteria;Bacterial Infections;bacterial metabolism;Biology;career;Cessation of life;Child;Citrobacter rodentium;clinically relevant;Collaborations;commensal bacteria;Communities;Coupled;cytokine;Data;Development;Diet;dietary;dietary approach;Dietary Component;Dietary Factors;Disease;enteric infection;enteropathogenic Escherichia coli;Environment;Enzymes;Epithelium;Fabaceae;Food;Formulation;Foundations;Future;Genes;Germ-Free;Gnotobiotic;Goals;Health;Host Defense;Host Defense Mechanism;host microbiota;Host resistance;Human;Immune response;Immunity;Immunology;immunoregulation;improved;Infection;Infection prevention;infectious disease treatment;Inflammation;Ingestion;innovation;Inositol Phosphates;insight;interest;interleukin-22;Intervention;intestinal epithelium;Intestines;K-Series Research Career Programs;Knockout Mice;Knowledge;Link;Mammals;Mediating;Mentors;Metabolism;Metagenomics;Microbe;microbial;microbiota;Modernization;Mouse Strains;mucosal site;Mucous Membrane;Mus;Natural Immunity;novel;novel strategies;Nutrient;nutrient metabolism;nutrition;Nutritional;Nuts;Organoids;pathogenic bacteria;Phosphorus;phytate;Phytic Acid;Postdoctoral Fellow;Predisposition;prevent;Prevention;receptor;Recovery;Regulation;Research;Research Personnel;Role;Scientist;STAT3 gene;synergism;Technical Expertise;Testing;tool;Training;Veterinarians;Work

PROJECT_TITLE: Commensal bacterial metabolism of dietary phytate in host defense


NIH_SPENDING_CATS: Bioengineering

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

PHR: Narrative  The X-ray Free Electron Laser (XFEL) allows for structural determination of enzyme-substrate/drug interactions at room temperature under functional conditions, and promises to be a revolutionary new tool for studies in structural biology and the biomedical sciences. Today such studies are nevertheless often limited due to the absence of methods to trigger/synchronize the enzymatic reaction or the high sample consumption rates of existing sample delivery systems, as the sample needs to be replenished at the high repetition rate of the X- ray laser pulses. We will develop sample delivery mechanisms that ensure precise control of the sample environment (temperature, pressure, gas environment) while allowing to work with scarce samples and triggering a wide variety of reactions, in particular, by chemical mixing, temperature jump, or electrochemical activation, with parallel multimodal detection schemes and integrate these with existing experimental stations at various user facilities.

PI_NAMEs: KERN, JAN F (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: 3-Dimensional;Acoustics;Area;Back;Biochemical Reaction;Biological;Biological Models;biological systems;Catalysis;Chemical Models;chemical property;Chemicals;Collection;Communities;computer studies;computerized tools;Consumption;Cryoelectron Microscopy;cryogenics;Crystallography;Data;Data Analyses;Data Collection;Deposition;design;Detection;detection method;detector;Development;Dimensions;Dose;Drops;Drug Interactions;Drug Targeting;electrical potential;Electron Beam;Electrons;Ensure;Environment;Enzymatic Biochemistry;enzyme model;enzyme substrate;Enzymes;experimental study;Feedback;Four-dimensional;Freezing;frontier;Funding;Future;Gases;Growth;improved;In Situ;Individual;Injections;instrumentation;interest;Kinetics;Lasers;Light;Liquid substance;Measurement;Measures;Metabolism;Methods;Microfluidics;Modeling;Modification;Molecular;Molecular Machines;movie;multimodality;operation;Photons;Physiologic pulse;Physiological;Population;pressure;Process;prototype;Radiation induced damage;Reaction;Research;Resolution;Rest;Roentgen Rays;Sampling;Scheme;Science;simulation;Source;Stimulus;structural biology;Structure;success;synchrotron radiation;System;Techniques;Technology;Temperature;temperature jump;Testing;Therapeutic;Thermodynamics;Time;tool;Transducers;Work;X ray diffraction analysis;x-ray free-electron laser

PROJECT_TITLE: High throughput sample delivery method for time resolved studies of enzyme reactions with X-ray and complementary techniques

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ORG_CITY: TUCSON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative The overarching goal of this project will be to develop a sophisticated new set of light activated chemical reactions that selectively form covalent bonds with specific types of biological structure. These new reactions will serve to further advances in biomedical sciences by enabling the design of new synthetic-biological hybrid molecules as well as allow scientists to study the molecular nature of biological processes in new and unprecedented ways. This in turn can lead to the discoveries into the nature of disease states and, ultimately, into opportunities to develop new, more effective treatments.

PI_NAMEs: TAYLOR, MICHAEL T (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: New Chemical Tools for Optically Controlled Protein Modification

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STRUCTURAL BIOLOGY CENTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Flaviviruses produce non-coding ‘subgenomic flavivirus RNAs’ (sfRNAs) during infection that interact with cellular proteins and manipulate the cellular environment. These sfRNAs are formed through partial degradation of the viral genomic RNA, when highly structured RNA elements block the progression of cellular 5’ to 3’ exoribonucleases in a defined location. We seek to understand the mechanism of these exoribonuclease- resistant RNA structures, how they regulate sfRNA production, and find more examples using a combination of structural biology, biochemistry, and virology.

PI_NAMEs: KIEFT, JEFFREY S (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: 3' Untranslated Regions;3-Dimensional;5' Untranslated Regions;Address;Anti-viral Response;Architecture;arthropod-borne;Attenuated;Biochemistry;Bioinformatics;Biophysics;Cells;Characteristics;Classification;Code;Complex;computerized tools;Coupled;Coupling;Cryoelectron Microscopy;Cultured Cells;Dangerousness;Data;Dengue;Dengue Virus;Directed Molecular Evolution;Disease;Elements;Environment;Enzymes;Exonuclease;Exoribonucleases;Flavivirus;genomic RNA;Health;human pathogen;In Vitro;Individual;Infection;insight;Japanese encephalitis virus;Kinetics;Knowledge;Laboratories;Learning;Link;Location;Mechanics;Modeling;Molecular;mosquito-borne;Outcome;Pathogenicity;Pattern;poly A specific exoribonuclease;Powassan virus;Process;Production;Property;Proteins;Regulation;Research;Resistance;Resolution;RNA;RNA Decay;RNA Folding;RNA Viruses;structural biology;Structure;success;Surface;Therapeutic Intervention;three dimensional structure;tick-borne;Tick-Borne Encephalitis Virus;tick-borne flavivirus;Untranslated RNA;Variant;Viral;Viral Genome;viral genomics;viral RNA;virology;Virus;Virus Diseases;West Nile virus;Work;X-Ray Crystallography;Yellow fever virus;ZIKA;Zika Virus

PROJECT_TITLE: Mechanisms of viral RNA maturation by co-opting cellular exonucleases

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Genetics

ORG_CITY: BIRMINGHAM

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: The proposed research is relevant to public health because comprehensive characterization of structural variations (SVs) using the new sequencing data and establish SV mechanism analysis will enable the discovery of disease causing mutations. Ultimately, it is expected to target the SV mutations and interfere SV associated genes or genomic regions to improve the health for all of us. The development of advanced analytic methods for genomic sequencing data from new technologies to understanding the mechanisms of genetic variations including SV is relevant to the part of NIH’s mission that pertains to seeking fundamental knowledge that will enhance health and reduce illness.

PI_NAMEs: CHONG, ZECHEN  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Advanced Development;Algorithms;analytical method;Architecture;Complex;Computational algorithm;Data;Detection;disease-causing mutation;Evaluation;Event;Genes;Genetic Variation;Genome;Genomic Segment;Genomics;Genotype;Goals;Haplotypes;Health;improved;Inherited;innovation;insight;Knowledge;Laboratories;Methods;Mission;Mutation;nanopore;new technology;novel;Organism;Outcome;Pathogenicity;Phenotype;Predisposition;Public Health;reference genome;Research;sequencing platform;Source;Technology;Testing;tool;trait;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Structural variation analysis with and without a reference genome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Pediatric;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Anxiety, one of most commonly diagnosed disorders in adolescence, is a potent predictor of adverse patterns of substance use (APSU). Certain aspects of neurodevelopment and emerging stress response systems may distinguish youth with anxiety symptoms who initiate early and rapidly escalate to APSU from adolescents with anxiety symptoms who exhibit more normative patterns of use or abstention. The proposed prospective, longitudinal project seeks to chart development of connections between neural networks that support cognitive control over emotional responses across adolescence to shed light on processes that predict pathways from anxiety to APSU with the goal to advance precision-based, personalized approaches.

PI_NAMEs: BELGER, AYSENIL  (contact);FISHBEIN, DIANA H;RIDENOUR, TY A

PROGRAM_OFFICER_NAME: PARIYADATH, VANI

PROJECT_TERMS: Acute;acute stress;Adolescence;Adolescent;adolescent substance use;Affective;Age;Amygdaloid structure;Anxiety;anxiety symptoms;Behavioral;behavioral outcome;biological adaptation to stress;Biological Markers;biomarker identification;Brain;Characteristics;Clinic;clinical diagnosis;Cognitive;cognitive control;Data;Data Collection;design;Detection;Development;Diagnosis;Disease;efficacious intervention;eligible participant;Emotional;Equipment and supply inventories;Etiology;Exhibits;Exposure to;externalizing behavior;Functional disorder;Functional Magnetic Resonance Imaging;Goals;graph theory;heart rate variability;Heterogeneity;high risk;high-risk adolescents;Hydrocortisone;improved;Impulsivity;Informal Social Control;information processing;Intervention;Link;longitudinal course;Longitudinal Studies;longitudinal, prospective study;Magnetic Resonance Imaging;Measures;medial temporal lobe;Modeling;Monitor;multimodal modeling;neural;neural network;Neural Pathways;Neurobiology;neurodevelopment;neuroimaging;Neurons;Outcome;Pathway interactions;Pattern;personalized approach;Physiological;Physiology;predictive marker;Process;programs;prospective;recruit;reduce symptoms;Regulation;Reporting;response;Rest;Risk;risk prediction;Role;Salivary;Sampling;secondary analysis;Severities;Sex Differences;social stress;Stress;stress reactivity;stressor;substance use;Substance Use Disorder;substance using adolescents;support network;Support System;Surveys;Symptoms;System;Task Performances;Testing;therapy design;Time;Work;Youth

PROJECT_TITLE: Developmental Pathophysiology of Adverse Patterns of Substance Use in Adolescents with Anxiety

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative Alzheimer’s disease (AD) and related dementias are a widely recognized major public health problem in the U.S. and globally. The proposed international collaborative project will contribute rich longitudinal biomarker and clinical data and over 1000 whole genome sequences on a Korean cohort to the NIA AD Sequencing Project and related research programs. Well-characterized multi-ethnic genomic data sets are a major priority for AD research. KBASE2 brings a multidisciplinary team together to complete state of the science integrative analyses of the clinical, genetic, brain network and multi-omics data to accelerate the identification of new potential therapeutic targets.

PI_NAMEs: LEE, DONG YOUNG ;NHO, KWANGSIK TIMOTHY;SAYKIN, ANDREW J (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Acceleration;Address;Age;Aging;aging brain;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;American;Amyloid;Angiography;Asian;Asian population;Automobile Driving;Back;Biological Markers;Blood;Blood Vessels;Brain;California;cerebrovascular;Clinical;Clinical assessments;Clinical Data;Cognition;Cognitive;cohort;Collaborations;Collection;comparative;computerized data processing;Data;Data Collection;data harmonization;Data Set;data sharing;data storage site;Dementia;design;Development;Diagnostic;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;drug development;Early Diagnosis;Elements;endophenotype;Enrollment;Ethnic Population;European ancestry;fluorodeoxyglucose positron emission tomography;Follow-Up Studies;functional genomics;Functional Magnetic Resonance Imaging;Genes;Genetic;genetic analysis;Genetic Risk;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;Genome;genomic data;Genomics;Goals;Heterogeneity;Image;imaging biomarker;Indiana;insight;Institution;International;Korea;Koreans;Laboratories;Late Onset Alzheimer Disease;lifestyle data;longitudinal analysis;Machine Learning;Magnetic Resonance Imaging;member;Memory;Methods;mild cognitive impairment;Molecular;multi-ethnic;multidisciplinary;multimodal data;multimodal neuroimaging;multimodality;Multiomic Data;multiple omics;Nerve Degeneration;Network-based;neuroimaging;neuroimaging marker;novel diagnostics;novel strategies;Participant;Pathology;Pathway Analysis;Pathway interactions;Pennsylvania;Phenotype;polygenic risk score;Population;Positron-Emission Tomography;precision medicine;prevent;Prevention;Process;prognostic;programs;progression marker;prospective;Prospective, cohort study;protective allele;Public Health;Reporting;Research;Resources;Rest;Risk;risk variant;sample collection;Sampling;Science;specific biomarkers;Systems Biology;tau Proteins;therapeutic development;therapeutic target;transcriptome sequencing;transcriptomics;Translations;Universities;whole genome;working group

PROJECT_TITLE: KBASE2: Korean Brain Aging Study, Longitudinal Endophenotypes and Systems Biology

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Atherosclerosis;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Heart Disease;Heart Disease - Coronary Heart Disease;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The primary objective of this study is reduce cognitive impairment after coronary artery bypass graft (CABG) surgery. Our central hypothesis is that CABG using multiple arterial grafts will be associated with less cognitive impairment than CABG with single arterial grafts, due to less intraoperative aortic manipulation, better patency of arterial compared to saphenous grafts, and lower risk of revascularization. The proposed study will leverage an international cohort determine: 1) the impact of CABG surgical technique on short-term cognitive domain impairments by sex and among patients with diabetes; 2) the impact of surgical technique on multiple cognitive domains in the year after surgery; and 3) the relationships between CABG surgery, brain infarction, novel biomarkers of brain health, and cognitive performance.

PI_NAMEs: GAUDINO, MARIO FL;MASTERSON CREBER, RUTH MARIE (contact);SWARTZ, RICHARD

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Acute;acute stroke;Address;Adult;Affect;Age;Alleles;American;Aorta;Apolipoprotein E;Biological Markers;Brain;Brain Embolism;brain health;Brain Infarction;Cardiac;Cardiac Surgery procedures;Cerebrum;Clinical;Cognition;Cognitive;cognitive function;cognitive performance;cognitive testing;cohort;comorbidity;computerized;Coronary Artery Bypass;Coronary heart disease;Country;Data;Day Surgery;Dementia;Diabetes Mellitus;Diffusion Magnetic Resonance Imaging;Early Intervention;Evaluation;Event;follow-up;Future;Genotype;Glial Fibrillary Acidic Protein;Goals;Impaired cognition;Impairment;Infarction;Inflammation;Infrastructure;International;Intervention;Language;Legal patent;Light;Magnetic Resonance Imaging;Measures;men;mild cognitive impairment;Multilingualism;Nerve Degeneration;neurofilament;Neuron-Specific Enolase;Neuronal Injury;novel;novel marker;Operative Surgical Procedures;Outcome;Participant;Patient Care;Patients;Persons;Phosphorylation;Postoperative Period;prevent;programs;Public Health;Randomized;recruit;Representational Oligonucleotide Microarray Analysis;Research;revascularization;Risk;Risk Factors;Sampling;Science;Screening procedure;Serum;sex;Short-Term Memory;Site;Specific qualifier value;Stroke;Subgroup;Surgeon;Surrogate Endpoint;tau Proteins;tau-1;Techniques;Thromboembolism;Time;Vascular Cognitive Impairment;verbal;Woman

PROJECT_TITLE: Randomized Comparison of the Clinical Outcome of Single Versus Multiple Arterial Grafts: Cognition (ROMA:Cog)

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: Precise control of blood flow is essential for ensuring brain cells have enough energy (extracted from the sugar, glucose, and oxygen) to fulfill their functions. Early in the development of Alzheimer’s disease—a devastating condition affecting almost 6 million Americans—brain blood flow control is disrupted, but it is unclear how this happens. Here, we reveal a novel electrical signaling mechanism that brain pericytes (cells that sit on the smallest blood vessels -capillaries) use to adjust blood flow to compensate for decreases in local glucose and protect brain metabolism. We demonstrate that this mechanism is disrupted in a mouse model of Alzheimer’s disease, leading to loss of blood flow control. Therefore, this work may identify novel targets on pericytes for therapies aimed at protecting or restoring blood flow in Alzheimer’s patients.

PI_NAMEs: LONGDEN, THOMAS A (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Actins;Acute;Adenosine Triphosphate;Affect;Aging;Agonist;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;American;arteriole;Astrocytes;Blood;Blood capillaries;Blood flow;Blood Vessels;Brain;brain cell;brain control;Brain Diseases;brain metabolism;brain parenchyma;brain pericytes;Calcium;Calcium Channel;capillary bed;Cells;cerebral capillary;Cerebrovascular Circulation;Communication;Compensation;Coupling;Data;Dementia;deprivation;Development;Diameter;Disease Progression;efficacy evaluation;Electrophysiology (science);Elements;Endothelial Cells;Energy Supply;Ensure;Event;experimental study;falls;Fatigue;Foundations;Functional disorder;Gap Junctions;Glucose;Health;Hemorrhage;Homeostasis;Hyperemia;Hyperglycemia;Impaired cognition;Impairment;Ion Channel;Link;Measures;Mediating;Metabolic;Metabolism;Molecular;mouse model;multiphoton imaging;Mus;neural;Neuroglia;Neuronal Dysfunction;Neurons;neurovascular coupling;novel;novel therapeutics;Oxygen;parenchymal arterioles;patch clamp;Pathologic;Pericytes;Physiology;Population;Positioning Attribute;Potassium;Process;promoter;Protocols documentation;Publishing;Regulation;Relaxation;response;Role;Sentinel;Signal Transduction;SLC2A1 gene;Slice;Smooth Muscle;sugar;targeted treatment;Testing;Therapeutic Intervention;Time;Trees;Work

PROJECT_TITLE: Pericytes as metabolic sentinels in the control of brain blood flow in health and Alzheimer's disease


ORG_DEPT: NUTRITION

PHR: Project Narrative Dysregulated metabolism and obesity-associated diseases, particularly diabetes, have reached epidemic proportions world-wide. There is growing need to train scientists who meld the entire “tool chest” of biological techniques to study the regulation of metabolism as it relates to human disease risk on the on all levels ranging from humans, to animal models, and cellular and molecular mechanisms. This inter-departmental, trans- institutional training program in Metabolic Biology unites faculty at the University of California-Berkeley in the Department of Nutritional Sciences and Toxicology (UCB-NST) and the University of California-San Francisco Diabetes Center (UCSF-DC) to train scientists capable to generate insight into mechanisms of disease and disease risk related to intermediary metabolism and metabolic regulation.

PI_NAMEs: STAHL, ANDREAS  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Biology;Metabolic;Training Programs

PROJECT_TITLE: Training Program in Metabolic Biology

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]