NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Alzheimer's disease (AD) and Parkinson's disease (PD) are progressive neurodegenerative diseases that destroy brain cells over time. Markers to detect changes in AD brain and to identify groups at high-risk for AD are lacking, as are markers that can distinguish AD from PD. The proposed studies will establish specific biomarkers for AD and PD by combining the physical features, surface marker profiles, miRNAs, and proteins in CSF EVs, and establish the neurologically relevant gene targets of AD EV miRNAs in human brain.

PI_NAMEs: SAUGSTAD, JULIE ANNE (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abnormally phosphorylated tau;Age;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid beta-42;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-4;Astrocytes;Autopsy;Biogenesis;Biological Assay;Biological Factors;Biological Markers;biomarker identification;Brain;brain cell;brain control;candidate identification;candidate marker;care costs;Cause of Death;cell type;Cells;cerebral atrophy;Cerebrospinal Fluid;Classification;Cognitive;comparison control;cost;Data;Dementia;Dependence;Disease;disorder control;Enzyme-Linked Immunosorbent Assay;Etiology;exosome;extracellular vesicles;Female;Flow Cytometry;frontal lobe;Functional disorder;Gene Targeting;Genetic;genetic risk factor;Genotype;Goals;High Prevalence;high risk;Hippocampus;Human;human old age (65+);Immunohistochemistry;improved;In Vitro;in vivo;Individual;Information Theory;Inherited;Living Donors;Luciferases;male;Measurement;Measures;Memory Loss;men;Messenger RNA;Methods;microRNA biomarkers;MicroRNAs;microvesicles;mild cognitive impairment;Molecular;Molecular Sieve Chromatography;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;Neurologic;Neurons;new therapeutic target;Parkinson Disease;Participant;particle;Pathogenesis;Pathologic Processes;Patients;payment;Persons;Process;Progressive Disease;protein biomarkers;protein expression;Proteins;Proteomics;Qualifying;Regulation;Reporter;Research Personnel;Research Priority;response;Risk;Risk Factors;sex;specific biomarkers;statistics;Surface;tau Proteins;tau-1;Time;Transfection;Transmission Electron Microscopy;Vesicle;Western Blotting;Woman

PROJECT_TITLE: Human Cerebrospinal Fluid Extracellular Vesicles: Utility as Disease Specific Biomarkers and Impact on Alzheimer's Disease Pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Q(55)R]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DALLAS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: It has been long known that different types of RTK exhibit great diversification in receptor activation and regulation. To better understand the diversification in RTK activation, we propose to determine the active structures of MuSK, TAM and c-MET receptors, three unique RTKs that are predicted to use distinct mechanisms for receptor activation. Solving the active structures of different members of RTK family will reveal similarities and differences in molecular mechanisms underlying the activation of RTK.

PI_NAMEs: BAI, XIAOCHEN  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: adaptive immunity;Affect;Agonist;Agrin;antagonist;Binding;Biochemical;Biological Assay;Biological Process;Cell membrane;Cell Physiology;Cell surface;Cell Surface Receptors;Cells;Complex;crosslink;Cryoelectron Microscopy;Cytoplasm;Data;Development;dimer;Dimerization;Environment;Exhibits;extracellular;Family;Goals;Heparin;HGF gene;human disease;improved;In Vitro;Inflammation;insight;KDR gene;Laboratories;Learning;Length;Ligand Binding;Ligands;Link;Lipids;Liposomes;Maintenance;Malignant Neoplasms;member;Membrane;Membrane Lipids;Modeling;Molecular;Molecular Conformation;Motility;Muscle;Muscle Cells;Mutagenesis;nanodisk;Neuromuscular Junction;Normal Cell;PDGFRB gene;Phosphatidylserines;Phosphorylation;Phosphotransferases;Physiological;Play;Protein Isoforms;Proteins;Protomer;receptor;Receptor Activation;Receptor Protein-Tyrosine Kinases;reconstitution;recruit;Regulation;Resolution;Role;Sampling;Signal Transduction;Structure;TAC1 gene;Tertiary Protein Structure

PROJECT_TITLE: Structural insights into the unique activation mechanisms of receptor tyrosine kinases

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Immunotherapy;Infectious Diseases;Kidney Disease;Orphan Drug;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project narrative New approaches to treat human glomerular diseases are needed. In this proposal, we plan to develop new treatment strategies by depleting the cytokine storm that causes relapse of human Minimal Change Disease and Focal and Segmental Glomerulosclerosis.

PI_NAMEs: CHUGH, SUMANT SINGH (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Acute;adaptive immune response;adaptive immunity;Albuminuria;Alleles;ANGPTL4 gene;Animal Disease Models;Antibodies;BALB/cJ Mouse;Binding;Body Surface;Cell membrane;Cell Nucleus;Cells;Common Cold;Common Cold Virus;CRISPR/Cas technology;cytokine;Cytokine Receptors;cytokine release syndrome;Dependence;design;Development;Disease;Dissociation;Down-Regulation;Endothelial Cells;Ephrin-B1;Event;Exclusion;Focal and Segmental Glomerulosclerosis;Genes;Genomics;Glucocorticoids;glutamyl aminopeptidase;Histology;Hodgkin Disease;Homeobox;Homeodomain Proteins;Human;IL-13Ralpha1;in vivo;Inbred BALB C Mice;Individual;Infection;Injections;Innate Immune Response;insertion/deletion mutation;Intercellular adhesion molecule 1;Interferon Type II;Interleukin 2 Receptor Gamma;Interleukin 4 Receptor;Interleukin-10;Interleukin-2;Interleukin-6;intravenous injection;Kidney;Link;LoxP-flanked allele;Mediating;Mediator;member;Membrane;mesangial cell;Modeling;Mus;Myristica fragrans;Nasal Epithelium;Natural Immunity;Nature;novel;novel strategies;novel therapeutic intervention;Nuclear;Patients;Pharmaceutical Preparations;podocyte;prevent;Process;Proteins;Proteinuria;Rattus;receptor;Recurrent disease;Relapse;relapse prevention;Renal glomerular disease;Rhinitis;Rhinovirus;Signal Pathway;Stimulus;synergism;System;targeted treatment;Therapeutic;TNF gene;Toxic effect;transcription factor;Untranslated RNA;Variant;Zinc Fingers

PROJECT_TITLE: Soluble mediators of relapse

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Disease;Nutrition

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease that is linked to obesity. NAFLD has no approved medications, due to incomplete understanding of the underlying molecular mechanisms and its progression to steatohepatitis (NASH) and fibrosis, which are the major causes of morbidity and mortality. This project takes a translational approach by focusing on kisspeptin, a liver factor we have determined critically controls liver fat and NAFLD progression.

PI_NAMEs: BHATTACHARYA, MOSHMI M (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Adult;Affect;Agonist;Binding;Biochemical;chronic liver disease;Cicatrix;Cirrhosis;clinical biomarkers;clinical diagnosis;clinically relevant;comparison control;Coupled;Data;Demographic Factors;Development;Diet;Disease;Disease Progression;Early Diagnosis;Evaluation;Exhibits;experience;Fatty acid glycerol esters;fatty acid oxidation;Fatty Liver;feeding;Female;Fibrosis;G-Protein-Coupled Receptors;gain of function;Goals;Government;GTP-Binding Proteins;Hepatic;Hepatocyte;High Fat Diet;Homeostasis;Human;improved;In Vitro;in vivo;Inflammation;Inflammatory;Insulin Resistance;KISS1 gene;KISS1R gene;Knock-out;Knockout Mice;Knowledge;Laboratories;Ligands;Link;lipid biosynthesis;lipid metabolism;Lipids;Liver;liver biopsy;Liver Fibrosis;liver function;loss of function;male;Mass Spectrum Analysis;Measures;Messenger RNA;Metabolic;Metabolic Diseases;Metabolic syndrome;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;Obesity;pandemic disease;Pathogenesis;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Plasma;Primary carcinoma of the liver cells;Proteins;radiological imaging;receptor;Receptor Activation;receptor expression;Receptor Inhibition;Receptor Signaling;Regulation;Risk;Role;sensor;Severity of illness;Signal Pathway;Signal Transduction;Source;Staging;Steatohepatitis;Technical Expertise;Testing;therapeutic development;therapeutic target;translational approach;Triglycerides;United States;United States National Institutes of Health;Up-Regulation;Virus;Work

PROJECT_TITLE: Hepatic fat accumulation in nonalcoholic fatty liver disease: critical regulation by kisspeptin signaling

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Cerebrovascular;Clinical Research;Networking and Information Technology R&D (NITRD);Neurosciences;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative Task-based functional MRI (fMRI) is a non-invasive clinical tool for presurgical localization of eloquent brain areas (e.g. motor and language areas) to prevent post-surgical deficits for patients with brain cancers, epilepsy, or other focal pathologies undergoing surgical resection of the lesion. However, task-based fMRI fails in patients who cannot perform the tasks and in brain areas with impaired neurovascular coupling induced by the lesion. The proposed research aims to create robust and vetted clinical software solutions that will enable emerging fMRI methods, including resting-state fMRI and cerebrovascular reactivity mapping, to greatly increase the patient population who can benefit from presurgical fMRI and to improve confidence in functional localization for surgical planning.

PI_NAMEs: ELSINGER, CATHERINE L;LIU, HO-LING ANTHONY  (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: Area;blood oxygen level dependent;blood oxygenation level dependent imaging;Blood Vessels;Brain;Brain imaging;Brain Mapping;Brain Neoplasms;brain surgery;brain tumor resection;cerebrovascular reactivity;Clinical;clinical care;Clinical Investigator;Communities;Computer software;Data;Data Set;Disease;Ensure;Environment;Epilepsy;Excision;Failure;flexibility;foot;Functional Magnetic Resonance Imaging;graphical user interface;Hand;Hypercapnia;Image;imaging detection;Impairment;improved;independent component analysis;innovation;Institution;Language;Lesion;Linear Models;Magnetic Resonance Imaging;malformation;Malignant neoplasm of brain;Maps;Measurement;Measures;Methods;Morbidity - disease rate;Motor;Navigation System;Neoplasms;Nervous System Disorder;Neurosciences;Neurosciences Research;neurosurgery;neurovascular;neurovascular coupling;novel;Operative Surgical Procedures;Pathology;Patient Compliance;patient population;Patients;preservation;prevent;Procedures;Process;Research;Rest;Seasons;Signal Transduction;software development;Software Tools;Software Validation;standard of care;Surgeon;Technology;Testing;Tissues;Tongue;tool;Visual;visual map;Visualization;Work

PROJECT_TITLE: A Comprehensive Clinical fMRI Software Solution to Enable Mapping of Critical Functional Networks and Cerebrovascular Reactivity in the Brain


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: NARRATIVE There are large unexplained inter-individual differences in systemic allostatic load and stress reactivity, which may in part be explained by mitochondria. Here we study the effects of chronic dysregulation of mitochondrial function – mitochondrial allostatic load (MAL) – on multisystem stress regulation in humans. This project will establish the influence of MAL on baseline AL as well as multisystem stress reactivity profiles, defining novel psychobiological pathways by which mitochondria may contribute to the maintenance of health and resilience, and to disease risk.

PI_NAMEs: PICARD, MARTIN  (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Adrenal Glands;allostatic load;Animals;Anxiety;Autonomic nervous system;Biological;biological adaptation to stress;Biological Markers;Biology;biomarker signature;Blood;Blood Pressure;Brain;Calibration;Cardiovascular system;Catecholamines;Cells;Chronic;classification algorithm;Clinical;Clinical Data;Cognitive;cognitive function;Control Groups;cytokine;Cytoplasm;Data;Data Analytics;Defect;Dependence;depressive symptoms;Disease;Disease Pathway;disorder risk;Energy Supply;epigenome;Esthesia;Executive Dysfunction;executive function;Exhibits;experience;Exposure to;Fasting;Fatigue;Future;Galvanic Skin Response;Gatekeeping;Generations;Genetic;Genome;Glucocorticoids;Hair;Health;Heart;heart rate variability;Hematology;Hormones;Hour;Human;Hydrocortisone;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;IL6 gene;Immune;Immune system;indexing;Individual;Individual Differences;Inflammatory;Inherited;insight;instrument;Laboratories;Leukocytes;Link;machine learning model;Maintenance;Maps;Measures;Mental Depression;Metabolic;Methods;Mitochondria;Mitochondrial DNA;Molecular;Monitor;Moods;mouse model;multidimensional data;Mus;National Institute of Mental Health;negative affect;negative mood;Neuropsychology;Neurosecretory Systems;novel;Organelles;Participant;Pathway interactions;Personal Satisfaction;personalized predictions;Persons;Phenotype;Physiological;Physiology;Pituitary Gland;Population;Positioning Attribute;positive mood;pre-clinical;preclinical study;Process;Protocols documentation;psychobiologic;psychologic;Psychological Stress;Psychophysiology;psychosocial;Psychosocial Factor;Recovery;Regulation;resilience;respiratory;Respiratory Chain;response;Rest;Role;Saliva;Signal Transduction;Sorting;Source;Specificity;Standardization;Stress;stress reactivity;Structure;System;Testing;Time;trait;Translating;Trier Social Stress Test;urinary

PROJECT_TITLE: Mitochondrial regulation of stress reactivity in humans

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Pediatric;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Early life environmental exposures can alter the developmental trajectory by disrupting the homeostasis of one or more systems, and in doing so produce identifiable biochemical signatures characteristic of the disease process or outcome. We are proposing a new paradigm that will detect disease years before current clinical and biochemical tests. By doing so we may be able to predict and even prevent diseases decades before any clinical signs.

PI_NAMEs: ARORA, MANISH  (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Adult;Area;Biochemical;Biochemical Pathway;Body Temperature;Characteristics;Childhood;Clinical;course development;Development;Disease;Environmental Exposure;Exhibits;fetal;Fetal Development;Growth;Health;Homeostasis;Human;Human Characteristics;Hydrocortisone;late life;Life;Medical;Menstrual cycle;new technology;Onset of illness;Outcome;Periodicity;Physiological Processes;Physiology;postnatal;prevent;Process;prognostic;Research;Sleep;System;Technology;temporal measurement;Testing

PROJECT_TITLE: Early Warning Systems for Childhood and Adult Disorders


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cancer;Genetics;Skin Cancer

ORG_DEPT: DERMATOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Cyclic AMP (cAMP) signaling is central for skin pigmentation and has a significant impact on skin cancer and melanoma risk. Whereas the canonical melanocyte cAMP cascade controls pigmentation by activating pigment gene expression via established mechanisms, we recently identified a second cAMP cascade that is distinct from the canonical pathway and controls pigmentation by regulating melanosome pH. Using novel in vitro and in vivo approaches for the investigation of cAMP, we will identify the upstream and downstream mechanisms of cAMP-dependent regulation of melanosome pH.

PI_NAMEs: ZIPPIN, JONATHAN HALE (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: 5'-AMP-activated protein kinase;Address;Adenylate Cyclase;Affect;African;African American population;Albinism;Alleles;Bicarbonates;cancer risk;carcinogenicity;Cell Line;Cell model;Cells;conditional knockout;Cutaneous;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Disease;Enzymes;eumelanin;experimental study;Gene Expression;Genes;Genetic;Genetic Models;Genetic Polymorphism;Human;In Vitro;in vivo;inhibitor;innovation;insight;Investigation;Ion Channel;Knock-out;Knockout Mice;Link;loss of function;Mass Spectrum Analysis;Measures;Melanins;Melanocortin 1 Receptor;melanocyte;Melanoma;Melanosomes;Membrane;Methods;Microscopy;Modeling;Modification;Monophenol Monooxygenase;mouse model;Mus;Mutation;new therapeutic target;novel;novel therapeutics;Oculocutaneous albinism type 2;Organelles;Pathway interactions;pharmacologic;photoprotection;Pigmentation physiologic function;Pigments;Protein Isoforms;Proteins;Publishing;Receptor Activation;Receptor Signaling;Regulation;Risk;Role;Signal Pathway;Signal Transduction;Skin Cancer;skin cancer prevention;Skin Pigmentation;solar ultraviolet radiation;synergism;Techniques;Testing;Therapeutic;tool;transcription factor

PROJECT_TITLE: Mechanisms of cAMP-dependent regulation of melanosome pH


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: NARRATIVE The poor understanding how red blood cells are produced poses a critical barrier to the development of artificial blood production systems, and of safer and more effective treatments for anemias and polycythemias, which affect millions of people in the U.S. This proposal aims to delineate molecular mechanisms that regulate erythropoiesis in erythropoietic stress and in polycythemia. Results from these studies will significantly improve our understanding of erythropoiesis and will shed light on the etiology of hematological malignancies and facilitate the design of novel therapeutic agents.

PI_NAMEs: HUANG, LILY JUNSHEN (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Acceleration;Acetylcysteine;Adult;Affect;alpha ketoglutarate;Anemia;Antioxidants;ascorbate;Ascorbic Acid;BFU-E;Binding;biological adaptation to stress;Blood Substitutes;Bone Marrow Transplantation;CD34 gene;Cell Culture Techniques;Cell Cycle;Cell division;Cells;Cellular Stress;CFU-E;chemotherapy;cofactor;demethylation;design;Development;differentiation in vitro;Dioxygenases;DNA;effective therapy;epigenome;Erythrocytes;Erythrocytoses;Erythroid;Erythroid Cells;erythroid differentiation;Erythropoiesis;Erythropoietin;Erythropoietin Receptor;Etiology;Exhibits;Funding;Goals;Growth;Health;Hematologic Neoplasms;Human;Impairment;improved;Infection;JAK2 gene;knock-down;Knockout Mice;Length;Mediating;Mediator;Molecular;Mus;mutant;Myeloproliferative disease;NADP;Names;Natural regeneration;nocturnin;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Oxidative Stress;Pathogenicity;Pathologic;Persons;Phosphoric Monoester Hydrolases;Polycythemia;Population;preservation;Process;Production;progenitor;Proliferating;Protein Tyrosine Kinase;Reactive Oxygen Species;receptor;Receptor Signaling;Recovery;response;Role;Signal Transduction;sodium DEPENDENDENT vitamin C transporter 1;stem cell population;Stress;System;Testing;Therapeutic Agents;Translating;Work

PROJECT_TITLE: Erythropoietin receptor signaling in stress erythropoiesis and erythrocytosis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Pregnancy;Prevention;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE The long-term goal of our work is to evaluate the effect of intensive postpartum blood pressure control on maternal cardiovascular health, risk of chronic hypertension, and reversal of vascular dysfunction generated by hypertensive disorders of pregnancy, thus attenuating the lifelong trajectory of cardiovascular disease risk.

PI_NAMEs: PALATNIK, ANNA  (contact)

PROGRAM_OFFICER_NAME: PEMBERTON, VICTORIA

PROJECT_TERMS: Acceleration;Adherence;Affect;Age;American Heart Association;Angiogenesis Inhibitors;Angiogenic Proteins;Anti-Hypertensive Agents;arm;arterial stiffness;Automobile Driving;Biological Markers;Biometry;Birth;black patient;Blood Glucose;blood lipid;Blood Pressure;blood pressure control;Blood Vessels;Body mass index;brachial artery;Brain hemorrhage;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Cessation of life;Chronic;Collection;Complication;Coupled;DASH diet;Data;design;Diastolic blood pressure;Diet;Discipline of obstetrics;Education;endothelial dysfunction;Endothelium;Ensure;Event;Exposure to;Face;feasibility testing;Femur;Future;Goals;good diet;Guidelines;healthy lifestyle;Heart failure;Hypertension;hypertension control;hypertensive;Impairment;improved;Incidence;Intervention;Knowledge;Life;Maternal-fetal medicine;Mediating;Medicine;multidisciplinary;Nature;Newly Diagnosed;nicotine exposure;Nifedipine;normotensive;Not Hispanic or Latino;nutrition;Participant;participant enrollment;Patients;Pharmaceutical Preparations;pharmacologic;Physical activity;Physiologic pulse;Pilot Projects;pilot test;Postpartum Hypertension;postpartum morbidity;Postpartum Period;Practice Management;Predisposing Factor;Pregnancy;pregnancy disorder;Prevalence;prevent;Procedures;Process;Provider;Public Health;racial disparity;Randomized;Randomized, Controlled Trials;Recommendation;Recovery;recruit;reproductive;Research;retention rate;Risk;Sampling;Site;Sleep;sleep health;stem;Surrogate Endpoint;Testing;Tobacco Use Cessation;treatment as usual;treatment guidelines;Variant;Vascular Diseases;Vascular Endothelial Growth Factor Receptor-1;Vascular remodeling;vasoconstriction;Woman;Work

PROJECT_TITLE: Intensive postpartum antihypertensive treatment to improve women's cardiovascular health

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(JA)]


ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative: The protein phosphatases PP1 and PP2A are ubiquitous ser/thr protein phosphatases that are critical during mitosis. Despite decades of research, most PP1 and PP2A substrates are still unknown. We have assembled a team of researchers that will overcome this challenge to allow for novel biological insights to be gained.

PI_NAMEs: PAGE, REBECCA  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Affinity;Anaphase;Binding;Biochemical;Biological;Biology;Biophysics;Calcineurin;CDC2 gene;Cell Cycle;Cell division;Cell Nucleus;Cell Physiology;Cells;Cellular biology;Characteristics;Chemicals;Chimera organism;Code;Complex;Coupled;Cryoelectron Microscopy;Data;design;Development;Disease;Drug Targeting;Enzymes;Escherichia coli;Family;Genes;glycogen metabolism;Goals;Health;Histidine;Holoenzymes;human disease;Human Genome;inhibitor;Insecta;insight;Knowledge;Lead;Malignant Neoplasms;Methods;Mitosis;Mitotic;Molecular;novel;Peptides;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Phosphotransferases;Post-Translational Protein Processing;premature;prevent;Process;Protein Dephosphorylation;protein function;Protein phosphatase;Protein Phosphatase 2A Regulatory Subunit PR53;Protein-Serine-Threonine Kinases;Proteins;Proteome;rational design;recruit;Regulation;Research;Research Personnel;Role;Serine;Signal Transduction;Site;Specificity;Structure;System;Systems Biology;Threonine;tool;Tyrosine;Work

PROJECT_TITLE: The regulation of phosphoprotein phosphatases in the nucleus


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Breastfeeding, Lactation and Breast Milk;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Maternal Health;Nutrition;Pediatric;Pregnancy;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: Bloomington

ORG_NAME: HEALTHPARTNERS INSTITUTE

ORG_STATE: MN

PHR: PROJECT NARRATIVE To date, there are limited data on the safety of COVID-19 vaccination in women who are pregnant or breastfeeding. The goals of this study are to assess the effect of COVID-19 vaccination during pregnancy and after delivery on lactation and select infant outcomes. The results of the study will complement ongoing vaccine safety surveillance and will help women and their clinicians make more informed decisions about COVID-19 vaccination during pregnancy or while breastfeeding.

PI_NAMEs: PALMSTEN, KRISTIN  (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Acute;Address;Age Months;antenatal;Biological;Body Composition;Breast Feeding;Breastfed infant;Cellular Phone;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical Trials;Complement;coronavirus disease;COVID-19;COVID-19 impact;COVID-19 vaccination;COVID-19 vaccine;cytokine;Cytomegalovirus;Data;Data Sources;Decision Making;Dehydration;Development;Discipline of obstetrics;Dose;Electronic Health Record;Enrollment;Epidemiologic Methods;Evaluation;Exclusion;Excretory function;Fatigue;Fever;Frequencies;Goals;Growth;Guidelines;health care delivery;health care service utilization;Health system;Healthcare;Human;Human Milk;Icterus;Immunization;immunogenic;Individual;Infant;Infant Care;infant outcome;Inflammatory;Inflammatory Response;Influenza;Lactation;Licensure;Link;Malaise;mastitis;medication safety;Methods;Milk;milk production;Monitor;Mothers;Nature;novel;novel strategies;Observational Study;Outcome;Patient Self-Report;Patients;Perinatal;perinatal period;Population;Positioning Attribute;Postpartum Period;Postpartum Women;Pregnancy;pregnant;Pregnant Women;Professional Organizations;programs;Publishing;Recommendation;Reporting;Respiratory syncytial virus;Risk;Risk Assessment;Risk Estimate;RNA vaccine;Safety;Sampling;Screening Result;Second Pregnancy Trimester;side effect;surveillance study;Surveys;symptomatic COVID-19;System;Third Pregnancy Trimester;Vaccinated;Vaccination;vaccine access;vaccine hesitancy;vaccine safety;vaccine trial;Vaccines;Viral Proteins;Viral Vector;volunteer;Well Child Visits;Woman;women's outcomes

PROJECT_TITLE: Maternal COVID-19 Vaccination and Lactation Outcomes


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Cardiovascular;Clinical Research;Genetics;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Breast cancer is the most commonly occurring cancer among women globally, while cardiovascular disease has become a leading cause of death among breast cancer survivors. Commonly used breast cancer treatments are known to cause cardiotoxicity, but the majority of studies have not examined the growing population of young and emerging adult breast cancer patients. The objective of this study is to develop a personalized model of psychosocial factors, traditional CVD risk factors, and molecular markers that predicts risk of cardiotoxicity among YEA breast cancer patients.

PI_NAMEs: HIBLER, ELIZABETH ANNE (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Address;Affect;Age;aged;Animals;Bioinformatics;brca gene;breast cancer diagnosis;Breast Cancer Patient;breast cancer survival;Breast Cancer survivor;Breast Cancer therapy;Breast Cancer Treatment;cancer diagnosis;cancer epidemiology;Cancer Patient;Cancer Survivor;Cardiac;Cardiac Myocytes;Cardiotoxicity;Cardiovascular Diseases;cardiovascular disorder risk;career;career development;case control;Cause of Death;chemotherapy;Chemotherapy-Oncologic Procedure;childhood cancer survivor;circulating biomarkers;Clinical;clinical care;Consumption;Data;design;Development;Diagnosis;Diet;DNA;DNA Sequence Alteration;Echocardiography;Electronic Health Record;emerging adult;Emotional;Epidemiologic Factors;Epidemiology;Etiology;experience;Exposure to;Face;follow-up;Future;Gene Combinations;Gene Expression;Gene Expression Profile;Gene Mutation;Genetic Predisposition to Disease;Goals;Health;Health behavior;Heart failure;Heart Injuries;high risk;Hypertension;Impairment;improved;Knowledge;Left Ventricular Ejection Fraction;Longevity;Longitudinal cohort;Longitudinal cohort study;Machine Learning;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Medical center;Medicine;Methods;Modeling;modifiable risk;Molecular;molecular marker;molecular modeling;Morbidity - disease rate;mortality;Mutation;National Heart, Lung, and Blood Institute;Nested Case-Control Study;novel;Obesity;Outcome;Participant;Patients;Pattern;Phenotype;physical inactivity;Population;Predictive Factor;predictive modeling;psychosocial;Psychosocial Factor;Public Health Informatics;Questionnaires;recruit;repaired;Research Personnel;Risk;Risk Factors;risk prediction;risk prediction model;risk sharing;skills;social;survivorship;therapy development;Time;Tissues;Training;Variant;Woman;young adult;young cancer survivor

PROJECT_TITLE: Predicting risk of cardiotoxicity among young and emerging adult breast cancer patients from treatment to survivorship

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE Receptor-induced Ca2+ signaling controls a wide array of physiological functions including proliferation, metabolism, and secretion. Replenishing the PIP2 lipid at the plasma membrane and Ca2+ stored in the endoplasmic reticulum that are consumed to generate Ca2+ signals during receptor-induced Ca2+ signaling is critical to the homeostasis of receptor-stimulated cells. Our proposed studies will provide new insight into the mechanisms underlying homeostatic regulation of PIP2-Ca2+ signaling and will lay the foundation for advances in treating diseases associated with deficiencies in proteins that regulate the PIP2-Ca2+ signaling system.

PI_NAMEs: LIOU, JEN  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Affect;Affinity;Antigen Receptors;Binding;Biochemical;Calcium Signaling;Cell membrane;Cells;Communication;Consumption;Cytoskeleton;Data;Diacylglycerol Kinase;Diglycerides;Disease;Endoplasmic Reticulum;Event;Foundations;G-Protein-Coupled Receptors;Goals;Growth Factor Receptors;Histamine;Homeostasis;Hydrolysis;Imaging Techniques;inorganic phosphate;Inositol;insight;Ion Transport;Kidney Failure;Knowledge;Ligands;Link;lipid transfer protein;Lipids;Mammalian Cell;Measures;Mediating;Membrane;Metabolism;migration;Molecular;Mutation;Neurotransmitters;Organelles;Patients;Phosphatidic Acid;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Phospholipase C;Physiological;Physiological Processes;Production;Proliferating;Protein Isoforms;Proteins;receptor;recruit;Regulation;response;Retinal Dystrophy;Shapes;Signal Transduction;STIM1 gene;synaptotagmin;System;Tertiary Protein Structure;Testing;Therapeutic;trafficking

PROJECT_TITLE: Homeostatic Regulation of PIP2-Calcium Signaling

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Principal Investigator/Program Director (Last, First, Middle): French, Christopher, Alexander Project Narrative NUT midline carcinoma is an incurable highly aggressive cancer driven by the BRD4-NUT oncoprotein that has a median survival of 6.5 months with no effective treatment options. We predict the proposed studies will identify mechanisms that collaborate with BRD4-NUT to drive NC growth while blocking differentiaiton that will facilitate precise and effective therapeutic targeting. The findings will greatly impact treatment of NC and likely other BRD4-dependent cancers. PHS 398/2590 (Rev. 09/04) Page Continuation Format Page

PI_NAMEs: FRENCH, CHRISTOPHER A (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Acetylation;Affect;Age;Binding;Bromodomain;Bromodomains and extra-terminal domain inhibitor;CDKN2A gene;Cell Cycle;Chromatin;Collaborations;Complex;Data;derepression;Disease;effective therapy;Enhancers;EP300 gene;Epigenetic Process;Exclusion;EZH2 gene;gene repression;Gene Targeting;Genes;Genetic Transcription;Goals;Growth;Histone Acetylation;histone acetyltransferase;Histones;Human;improved;In Vitro;in vivo;inhibitor therapy;Maintenance;Malignant Neoplasms;Methylation;Methyltransferase;Modeling;Mus;novel;Nut carcinoma;Oncogenes;Oncogenic;Oncoproteins;Outcome;Pathogenesis;Patients;permissiveness;Phase;Polycomb;pre-clinical;Principal Investigator;programs;Proliferating;Protein Family;Proteins;recruit;Repression;Role;senescence;small molecule;Squamous cell carcinoma;synergism;Testing;Therapeutic;therapeutic target;therapeutically effective;Toxic effect;Transcription Coactivator;tumor;Tumor Suppressor Genes;Xenograft procedure

PROJECT_TITLE: Pathogenesis and Treatment of NUT midline carcinoma

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ADMINISTERING_IC: NS

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Cerebrovascular;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: BOISE

ORG_NAME: BOISE STATE UNIVERSITY

ORG_STATE: ID

PHR: PROJECT NARRATIVE Dysfunction of the inner lining of blood vessels that form the blood-brain barrier (BBB) is implicated in progression and perpetuation of inflammation-associated diseases in the central nervous system, including multiple sclerosis, stroke, traumatic brain injury, dementia, encephalopathies, and brain metastases, that impact the lives of 9 million individuals in the United States and carry an annual cost burden of 300 billion dollars. This study will investigate how changes in the composition of the perivascular extracellular matrix, a dense meshwork of proteins that immediately surrounds the blood vessels, contribute to BBB dysfunction and will focus primarily on the two small leucine-rich proteoglycans (SLRP) decorin and biglycan, which have been observed at abnormally high levels in the perivascular matrix of patients with multiple sclerosis. Understanding the roles of these SLRPs in BBB dysfunction as well as the mechanisms by which they act may allow for the development of novel therapeutic targets for use in the treatment of a wide variety of CNS diseases.

PI_NAMEs: BEARD, RICHARD SCOTT (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acute;Adhesions;AKT2 gene;Animal Model;autocrine;Basement membrane;biglycan;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier function;Cell Adhesion Inhibition;Cell Communication;Cell Separation;Cells;Central Nervous System;Central Nervous System Diseases;Collagen Type IV;cost;Cues;Data;decorin;Dementia;Demyelinating Diseases;Development;Disease;Disease Progression;Down-Regulation;Encephalopathies;Endothelial Cells;Endothelium;Experimental Autoimmune Encephalomyelitis;Experimental Models;experimental study;expression vector;Extracellular Matrix;FOXO1A gene;Functional disorder;Future;gene repression;Gene Transfer;Genetic Transcription;Goals;Hemorrhage;Histopathology;Homeostasis;Impairment;In Vitro;in vivo;in vivo evaluation;Individual;Inflammation;Inflammation Mediators;Inflammatory;Injury;innovation;insight;integrin-linked kinase;Integrins;Interleukin-1 beta;Intervention;Knock-in Mouse;Knockout Mice;Knowledge;Laboratories;Lesion;Leucine;Liquid substance;Maintenance;Mediating;Metastatic malignant neoplasm to brain;Modeling;Molecular;mouse model;Multiple Sclerosis;multiple sclerosis patient;Nerve Degeneration;neuroinflammation;Neuronal Dysfunction;new therapeutic target;novel;overexpression;Pathogenicity;Pathologic;Pathway interactions;Persons;pharmacologic;Phase;Physiological;preservation;prevent;Protein Isoforms;Proteins;Proteoglycan;Proto-Oncogene Proteins c-akt;Regulation;Reporting;Repression;Research;Role;screening;seal;Signal Pathway;Signal Transduction;solute;Stroke;surface coating;Techniques;Testing;Therapeutic;Tight Junctions;Tissues;tool;Transgenic Mice;Translating;Traumatic Brain Injury;United States;Up-Regulation;Work

PROJECT_TITLE: Mechanisms for matrix-dependent BBB dysfunction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-E(02)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Precision Medicine;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Tuberculosis (TB) is the bacterial infection that kills the most people worldwide, especially in India, which has the highest burden in of drug-resistant tuberculosis in the world. Delays in adequate treatment due to slow diagnostic tests and the usual one-size-fits-all treatment strategy lead to new drug resistance, terrible treatment-associated side effects, and high mortality. In this observational cohort study we will assess the individual and combined impact of tools already in practice at our hospital to quickly test for drug resistance and measure drug levels in patients early in treatment to determine if this combination improves response to treatment, decreases the time that people can spread the disease, and reduces side effects commonly associated with TB treatment.

PI_NAMEs: TORNHEIM, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: LAUGHON, BARBARA E

PROJECT_TERMS: Adherence;Adult;Bacterial Infections;Biological Assay;biomedical referral center;Bone Marrow Suppression;brass;Caring;Cellular Phone;Clinical;clinical research site;cohort;Collaborations;Communicable Diseases;Complex;COVID-19;Cycloserine;Data;Development;diagnostic algorithm;Diagnostic tests;diagnostic tool;Disease;Dose;Drug Kinetics;Drug Monitoring;Drug resistance;Drug resistance in tuberculosis;Drug Targeting;drug testing;efficacy evaluation;efficacy outcomes;Electrocardiogram;Enrollment;Ensure;Evaluation;follow-up;Frequencies;Future;Genotype;Goals;Guidelines;Hospitals;Hour;implementation tool;improved;improved outcome;India;Individual;individualized medicine;ineffective therapies;Infrastructure;innovation;Laboratories;Lead;Linezolid;liver injury;Longitudinal cohort;Longitudinal cohort study;Lung;Measures;meetings;Methods;Minimum Inhibitory Concentration measurement;Modeling;Molecular;Monitor;mortality;Moxifloxacin;Multidrug-Resistant Tuberculosis;Mutation;National Institute of Allergy and Infectious Disease;Neuropathy;next generation sequencing;novel;novel diagnostics;novel therapeutics;observational cohort study;Oral;Outcome;Participant;Patient-Focused Outcomes;Patients;personalized strategies;Persons;Pharmaceutical Preparations;pharmacokinetic model;Phenotype;Plasma;Predisposition;Preparation;prevent;prognostic assays;Prospective, cohort study;Provider;Pulmonary Tuberculosis;Recommendation;Regimen;Reporting;Resistance;Rifampicin resistance;Rifampin;Safety;Sampling;Selection for Treatments;Severities;side effect;Site;Sputum;Strategic Planning;Test Result;Testing;Therapeutic;Time;tool;Toxic effect;transmission process;Treatment outcome;treatment response;treatment strategy;trial comparing;Tuberculosis;tuberculosis drugs;tuberculosis treatment;United States National Institutes of Health;Validation;Vision;Work

PROJECT_TITLE: Baseline pRescription According to Direct from Sputum Sequencing and TArgeted drug Concentration Strategy (BRASS TACS)

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Stroke

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Narrative  This project will perform whole-genome RNA sequencing from blood 1 and 3 days after stroke to develop gene profiles using machine learning that predict the outcomes at 90 days after stroke in a derivation cohort; and use the expression of these genes in blood from a separate validation cohort as the input into the same machine learning algorithm to predict 90 day outcomes of the validation cohort with >85% sensitivity and specificity. Gene expression will also be correlated with major clinical variables that are associated with stroke outcome, and utility of clinical variables for prediction of outcome compared to that for the gene expression profiles.

PI_NAMEs: ANDER, BRADLEY PEARCE;STAMOVA, BORYANA  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: 3-Dimensional;Age;AMPA Receptors;Anti-Inflammatory Agents;Atrial Fibrillation;Biological Markers;Biology;Blood;Blood Platelets;Blood Pressure;Brain;Brain-Derived Neurotrophic Factor;C-reactive protein;Clinical;Clinical Trials;Coagulation Process;cohort;Cytochrome P450;cytokine;Data;Derivation procedure;Diabetes Mellitus;Engineering;Environment;Etiology;functional outcomes;Future;Gene Expression;Gene Expression Profile;gene network;Genes;Genetic Markers;genetic risk factor;Genome;Glucose;Growth Factor;Heat shock proteins;Hemoglobin concentration result;HMGB1 gene;Human;Hyperlipidemia;IL6 gene;Immune;improved;indexing;Infection;Inflammatory;Interleukin-1;Interleukin-10;Ischemic Stroke;ITGB3 gene;kidney dysfunction;Knowledge;Leukocytes;Life Style;Light;Location;Logistic Regressions;Lymphocyte Count;Machine Learning;machine learning algorithm;machine learning prediction;Measures;Molecular;molecular marker;monocyte;neurofilament;Neurologic;neuronal excitability;neutrophil;Outcome;Outcome Measure;outcome prediction;PARK2 gene;Pathway Analysis;Pathway interactions;patient stratification;Patients;Pattern;peripheral blood;Phosphoric Monoester Hydrolases;Platelet Count measurement;post stroke;presynaptic;Prognosis;Proteins;PTGS2 gene;Recovery;Regulator Genes;repaired;response;RNA;Sensitivity and Specificity;Severities;sex;statistics;Stroke;stroke outcome;stroke patient;Stroke Volume;success;support vector machine;System;TNF gene;transcriptome;transcriptome sequencing;United States National Institutes of Health;Validation;vascular risk factor;whole genome

PROJECT_TITLE: Whole Transcriptome Studies of Blood to Predict Stroke Outcome

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: MISCELLANEOUS

PHR: NARRATIVE The proposed research seeks to address racial/ethnic disparities in chronic disease risk by evaluating a novel dyadic behavioral intervention focused on motivation, behavior skills, and building women's capacity to be a supportive partner to increase physical activity in dyads of inactive predominantly Latina and African American women. Research will yield critical insight regarding the effectiveness of dyadic approaches and how best to facilitate greater collaboration and support for increased physical activity among inactive women.

PI_NAMEs: STRONG, LARKIN  (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Address;Adoption;Adult;African American;African American Women;Area;Behavior;behavior change;Behavior Therapy;Behavioral;Blood Pressure;Body mass index;cancer health disparity;Cardiovascular Diseases;cardiovascular risk factor;Chronic Disease;Collaborations;Communication;Diabetes Mellitus;disorder risk;effective intervention;Effectiveness;effectiveness evaluation;effectiveness testing;Empathy;Enrollment;ethnic disparity;Ethnic Minority Women;Expectancy;Family;fitbit;Fostering;Friends;Goals;Health;Health education;healthy lifestyle;improved;improved outcome;Individual;innovation;insight;Intervention;Intervention Studies;Latina;Life Style;Literature;Long-Term Effects;Maintenance;Malignant Neoplasms;Measures;Mediator;member;men;Minority;Morbidity - disease rate;mortality;Motivation;Newsletter;Not Hispanic or Latino;novel;Obesity;Outcome;Participant;peer;Persons;Physical activity;physical inactivity;primary outcome;racial disparity;racial minority women;Randomized;randomized trial;Recommendation;recruit;Research;Resources;secondary outcome;sedentary;sedentary lifestyle;Self Determination;Self Efficacy;skills;social cognitive theory;Social Environment;Social Network;Social Processes;Social support;Source;Stroke;supportive environment;telephone based;theories;therapy design;Time;Training;Translating;waist circumference;Woman;Work

PROJECT_TITLE: Peer-Based Approaches to Enhance Physical Activity in Dyads of Inactive Women

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative At a single-cell level, mycobacteria grow and divide asymmetrically, producing subpopulations of cells that can survive antibiotic treatment. We have recently discovered that deleting a single gene collapses this heterogeneity. Here, we propose to investigate the function of this gene, with future work aimed at developing better tuberculosis therapies that can target asymmetric growth and division.

PI_NAMEs: REGO, ELIZABETH HESPER (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Antibiotic susceptibility;Antibiotic Therapy;Antibiotics;Bacteria;Bacterial Infections;Behavior;Biochemical;Cause of Death;Cell division;cell growth;Cell Survival;Cells;Characteristics;chemotherapy;Communication;Complex;Coupled;Cytokinesis;Data;Daughter;design;Disease;Drug Design;Drug Tolerance;Escherichia coli;Event;Experimental Genetics;experimental study;Frequencies;Future;Gene Deletion;gene function;Genes;Genus Mycobacterium;Goals;Growth;Heterogeneity;human pathogen;Imaging Techniques;Infection;Infectious Agent;innovation;Interruption;Intervention;Lead;Maps;Mediating;Methods;Modeling;Molecular;Multiprotein Complexes;mutant;mycobacterial;Mycobacterium Infections;Mycobacterium tuberculosis;Names;new growth;Organism;pathogenic bacteria;Peptidoglycan;Phenotype;Phosphorylation;Phosphotransferases;Population;Predisposition;prevent;Process;protein protein interaction;Proteins;Publishing;Regulatory Pathway;Resistance;Route;Series;Site;Source;Testing;Therapeutic;Time;Tuberculosis;tuberculosis treatment;Tyrosine;Work

PROJECT_TITLE: "The molecular mechanisms of asymmetric cell division in mycobacteria."

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Digestive Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The training of the next generation of knowledge creators in digestive diseases will require concerted efforts to harness the explosion of information that has been created by advances in genomics, functional genomics, network analysis, stem cell biology, the human microbiome, and other technologies. Now more than ever, a planned approach to the research career development of physician scientists – one that must incorporate solid scientific environment, mentorship, didactic curriculum, monitoring, and inter action – becomes critical to maximize likelihood of success. To preserve a training environment that, despite a challenging funding environment, has continued an exceptional track record of producing leaders in academic gastroenterology, we have retained preceptors from a stellar group of fundamental, translational and clinical scientists who have adapted and incorporated these recent advances while also having actively participated in mentoring.

PI_NAMEs: CHUNG, RAYMOND T (contact);GOESSLING, WOLFRAM

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Digestive System Disorders;Research Training

PROJECT_TITLE: Research Training in Digestive Diseases


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE Addressing social determinants of health is key to eliminating racial and ethnic health disparities among chronically ill elderly patients. Through a large, national, mixed-methods study, we will examine patients' neighborhoods and primary care practices where they receive care from nurse practitioners to produce evidence to help design future interventions to improve neighborhoods and strengthen primary care practices to ensure optimal care and outcomes for minority patients.

PI_NAMEs: POGHOSYAN, LUSINE  (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Accident and Emergency department;Address;Administrator;Adult;Affect;Area;behavioral health;built environment;care delivery;Care given by nurses;care systems;Caring;Chronic;Chronic Care;Chronically Ill;clinical care;Community Services;Competence;Coupled;COVID-19 pandemic;Data;design;Diabetes Mellitus;disease registry;Disparity;Economics;Education;Elderly;Ensure;Environment;ethnic disparity;ethnic health disparity;ethnic minority;Face;Future;Genetic Transcription;Geographic Information Systems;Glycosylated hemoglobin A;Health;health care availability;health care quality;health care settings;health data;health disparity;health equity;health professional shortage areas;Health Services;Health Status;Healthcare;Healthcare Systems;Hospital Departments;Hospitalization;Hospitals;human old age (65+);improved;Individual;innovation;Insurance Carriers;Intervention;Interview;Investments;Lead;Medicare;Medicare claim;Methods;Minority;minority patient;Modeling;multilevel analysis;neighborhood disadvantage;Neighborhoods;Nurse Practitioners;older adult;older patient;Outcome;Patient Care;Patient-Focused Outcomes;Patients;payment;Persons;Play;Policies;Policy Maker;Population;population health;prevent;Primary Care;Primary Care Physician;primary care practice;Primary Nursing Care;Process;Public Health;Quality of Care;racial disparity;racial health disparity;racial minority;Reduce health disparities;Registries;Reminder Systems;Resources;Role;routine care;Sampling;Service delivery model;Social Environment;social group;social health determinants;Structure;Surveys;System;Telephone;Testing;therapy design;Translating;underserved area;underserved community;United States;US State;Work

PROJECT_TITLE: Enhancing Nurse Practitioner Primary Care Delivery to Address Social Determinants of Health and Reduce Health Disparities: A mixed-methods national study

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Ménétrier’s disease is an acquired premalignant hypertrophic gastropathy caused by EGF receptor (EGFR) signaling activation in which the EGFR neutralizing monoclonal antibody, cetuximab, is the first effective medical therapy. My identification of Notch signaling downstream of EGFR signaling in Ménétrier’s disease has led to the design of present studies that will dissect the role of EGFR and Notch signaling in two cardinal features of the disease (loss of parietal cells and foveolar hyperplasia) and optimize pharmacological blockade of EGFR and Notch signaling to improve the treatment of affected individuals. The results of this study will enlighten the detailed pathogenesis of Ménétrier’s disease and lead to the development of clinical trials.

PI_NAMEs: HUH, WON JAE  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Abdominal Pain;Achlorhydria;Acids;Advisory Committees;Affect;Antibodies;Area;Atrophic;Award;career development;Cell Count;Cell Differentiation process;cell type;Cells;Cetuximab;Chief Cell;Clinical;clinical development;Clinical Trials;Data;design;Development Plans;Digestive System Disorders;Disease;Distal;Edema;Ensure;Epidermal Growth Factor Receptor;ES01;Event;Formalin;gamma secretase;Gastrectomy;gastric fundus;Gastric mucosa;gastric organoids;Gastric Parietal Cells;Generations;Genetic;Gland;Goals;Hand;Heavy Metals;Hyperplasia;Hypertrophic Gastritis;Hypoproteinemia;Immunofluorescence Immunologic;immunoreactivity;improved;in vivo;Individual;inhibitor;Knock-out;Knockout Mice;Label;Ligands;malignant stomach neoplasm;Medical;men;Mentors;Mentorship;Microscopic;middle age;Molecular;Mucous body substance;Mucous Membrane;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Nausea and Vomiting;neutralizing antibody;neutralizing monoclonal antibodies;notch protein;novel;overexpression;P2X-receptor;paracrine;Paraffin Embedding;Pathogenesis;Pathway interactions;Patients;Pattern;Peripheral;pharmacologic;Phenocopy;Physicians;premalignant;progenitor;programs;Proliferating;Proteins;receptor;Receptor Activation;Receptor Signaling;Regimen;Reporter;Research;Research Proposals;Resources;Risk;Role;Scientist;Signal Transduction;Signs and Symptoms;single-cell RNA sequencing;skills;Stains;stem;stem cells;Stomach;success;Surface;Symptoms;Therapeutic;therapeutically effective;Time;tool;Training;Transforming Growth Factor alpha;Transgenic Mice;Treatment Efficacy;Visualization;Western Blotting;Woman;Work

PROJECT_TITLE: EGF Receptor and Notch Signaling in the Pathogenesis of Menetrier's Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: TUCSON

ORG_NAME: NUVOX PHARMA, LLC

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Stroke affects more than 795,000 Americans each year, kills approximately 140,000 and costs the US $34B peryear; large vessel occlusion (LVO) strokes account for almost 40% of ischemic strokes but cause 95% of mortalities and 62% of long-term dependence. Mechanicalthrombectomy (MT) has emerged as standard of care treatment for LVO stroke but MT is only available at specialized hospitals. DDFPe decreases stroke damage by about 85%, with potential to improve outcomes in stroke patients allowing time for treatment with MT. SPAN is a new program that will test promising agents to improve outcomes in stroke; we propose that SPAN test DDFPe.

PI_NAMEs: UNGER, EVAN CHARLES (contact);WATERS, MICHAEL FARRIS

PROGRAM_OFFICER_NAME: JANIS, SCOTT

PROJECT_TERMS: Acute;Adult;Affect;aged;Alteplase;American;anaerobic glycolysis;Anesthesia procedures;animal old age;Animals;Applications Grants;Autopsy;Behavior;Blinded;Blood flow;Body Weight;Brain;Caring;Clinical Trials;cohort;comorbidity;Contrast Media;cost;Data;Dependence;Development;diabetic;diabetic rat;Dose;drug testing;Eligibility Determination;Emulsions;Exhalation;Experimental Designs;experimental study;Female;Filament;functional outcomes;Funding;Half-Life;Hospitals;Hour;Human;hypertensive;improved;improved outcome;Inbred SHR Rats;Injury;Ischemia;Ischemic Stroke;Magnetic Resonance Imaging;male;manufacture;manufacturing scale-up;Measurement;Measures;Mechanics;Medical;meetings;Middle Cerebral Artery Occlusion;Modeling;mortality;nano;Nervous System Physiology;Neurologic;Neurons;normotensive;Obesity;Operative Surgical Procedures;Oryctolagus cuniculus;Outcome;Oxygen;Patients;perfluoropentane;Pharmaceutical Preparations;Phase;Phase Ib/II Clinical Trial;Phase Ib/II Trial;phase II trial;Placebo Control;Placebos;post stroke;pre-clinical;preservation;Procedures;Production;programs;Protocols documentation;Randomized;Rattus;Reperfusion Therapy;Risk;Rodent;Route;scale up;Small Business Innovation Research Grant;Specific qualifier value;standard of care;Stroke;stroke model;stroke patient;Stroke Volume;Survival Analysis;Testing;Thinness;Thrombectomy;Time;tissue oxygenation;Tissue Preservation;Tissue Viability;ultrasound;United States National Institutes of Health;Wistar Rats;Zucker Rats

PROJECT_TITLE: Dodecafluoropentane emulsion (DDFPe), NanO2™ as Cerebroprotectant in Ischemic Stroke


ORG_CITY: Los Alamos

ORG_NAME: TRIAD NATIONAL SECURITY, LLC

ORG_STATE: NM

PHR: NARRATIVE This project will develop validated, publicly available, methods to estimate actual time since HIV infection and HIV incidence based on a flexible biomarker multi-assay algorithm with applicability to sample-based data, larger surveillance data streams, and more local levels among vulnerable sub-groups where it may matter most for prevention and contact tracing.

PI_NAMEs: LEITNER, THOMAS K. (contact)

PROGRAM_OFFICER_NAME: SHARMA, USHA K

PROJECT_TERMS: Age;AIDS prevention;Algorithms;Anti-viral Therapy;Avidity;Bayesian Method;Binding;Biological Assay;Biological Markers;Classification;cohort;Community Health;Confounding Factors (Epidemiology);Contact Tracing;Cross-Sectional Studies;Data;data imputation;Data Set;data streams;Databases;Development;Diagnosis;Dideoxy Chain Termination DNA Sequencing;DNA;Evaluation;flexibility;Gender;Genetic;Genetic Polymorphism;Genetic Recombination;Genetic Variation;Goals;high risk;HIV;HIV Infections;HIV Seropositivity;Human;Human immunodeficiency virus test;Immunologic Markers;improved;Incidence;Individual;Infection;Laboratories;Measurement;Measures;Methodology;Methods;Modeling;next generation;next generation sequencing;Outcome;Patient Selection;patient variability;Patients;Persons;Population;Prevention;Prevention program;Probability;Protocols documentation;Public Health;Publishing;Research;Role;Sampling;serological marker;South Africa;Statistical Models;Structure;study population;Subgroup;surveillance data;Surveys;Sweden;System;Time;tool;Training;training data;Uganda;Uncertainty;usability;user-friendly;Validation;Variant;Viral;web site;Work;Zimbabwe

PROJECT_TITLE: Next-generation algorithms using multiple biomarkers for precise estimation of HIV infection duration and population level incidence

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Dietary Supplements;Major Depressive Disorder;Mental Health;Mental Illness;Nutrition;Obesity;Precision Medicine;Serious Mental Illness

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: At least one-third of patients who receive treatment for major depressive disorder do not attain remission and there is a growing agreement that increased inflammatory activity contributes to the persistence of depressive symptoms in many of these patients, presenting the opportunity for novel treatment approaches. Omega-3 fatty acids reduce signs of inflammation and may have benefit for treatment of depression, especially in combination with other antidepressant drugs. This study will test whether omega-3 fatty acids added to ineffective antidepressant treatment increase compounds that resolve inflammation and whether the increase in these compounds is associated with improved antidepressant response.

PI_NAMEs: RAPAPORT, MARK HYMAN (contact)

PROGRAM_OFFICER_NAME: CHIDEYA-CHIHOTA, SEKAI RUTENDO

PROJECT_TERMS: Acids;Adopted;Adult;Agreement;anti-depressive agents;Antiinflammatory Effect;Attention;Body mass index;Chronic;Clinical;cohort;comorbidity;Complex;Consensus;Data;depressive symptoms;design;Disease remission;Docosahexaenoic Acids;dosage;Eicosapentaenoic Acid;Failure;functional outcomes;Future;Genes;Grant;Heterogeneity;improved;Individual;individualized medicine;Inflammation;Inflammatory;inflammatory marker;Intervention;inventory of depressive symptomatology;Knowledge;Link;lipid mediator;Lipids;Literature;Major Depressive Disorder;Masks;Mediating;Mediator;Medical;Mental Depression;Meta-Analysis;Mission;monoamine;Morbidity - disease rate;National Center for Complementary and Integrative Health;novel;Nutraceutical;obese person;Obesity;Omega-3 Fatty Acids;Overweight;patient population;patient subsets;Patients;Peripheral;Placebo Control;Placebos;Plasma;precision medicine;Randomized;Recording of previous events;Research Priority;Resolution;response;Safety;Sample Size;suicidal risk;Supplementation;Symptoms;Testing;treatment response;treatment strategy;treatment-resistant depression;Variant;Work

PROJECT_TITLE: Specialized pro-resolving lipid mediators and treatment resistant depression


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BLACKSBURG

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Limited information exists pertaining to the physiological relevance of innate immune regulation and the key players driving their phenotypic response following TBI. Completion of these studies will advance our understanding of the novel mechanisms regulating innate immunity and how peripheral-derived monocyte/macrophages dictates neurovascular injury and recovery in the pathophysiology of TBI. Exploiting new ways to promote the pro-resolving phenotype of innate immune cells represents a novel restorative intervention aimed at improving TBI outcomes and expanding novel targets for drug discovery.

PI_NAMEs: THEUS, MICHELLE LEE (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acceleration;Acute;Anti-Inflammatory Agents;Attenuated;Automobile Driving;Axon;axon growth;axon guidance;Behavior;Behavioral;behavioral phenotyping;Blood - brain barrier anatomy;Blood Vessels;Bone Marrow Cells;Cd68;Cells;Cerebrovascular Circulation;chemokine;Chronic;controlled cortical impact;cytokine;cytotoxic;Data;Demyelinations;Dendritic Cells;Dichloromethylene Diphosphonate;Disease Progression;drug discovery;Environment;EphA4 Receptor;epigenomics;FRAP1 gene;Functional disorder;genome-wide;glial activation;Health;Hippocampus;Histologic;Immune;immune activation;immunoregulation;improved;In Vitro;in vivo;Infiltration;Inflammatory;Inflammatory Response;injured;Injury;Innate Immune Response;innovation;Intervention;Knock-out;Knockout Mice;Label;Lesion;Liposomes;Macrophage;Mechanics;Mediating;Mediator;Methods;Modeling;Molecular;monocyte;mouse model;mRNA Expression;Mus;Natural Immunity;Natural Killer Cells;Neuroglia;neuroinflammation;Neurologic;neuron loss;neuroprotection;neurotoxic;neurovascular;neurovascular injury;neutrophil;new therapeutic target;novel;Outcome;Pathogenesis;Pathway interactions;Peripheral;pharmacologic;Phase;Phenotype;Phosphorylation;Physiological;Play;preclinical study;preservation;Process;Proteins;Publishing;Recovery;Recovery of Function;Regulation;repaired;Reporter;Research;response;Role;Signal Transduction;Testing;Time;Tissues;tool;transcriptomics;Transgenic Organisms;Trauma;Traumatic Brain Injury;Traumatic Brain Injury recovery;Up-Regulation

PROJECT_TITLE: Novel mechanisms suppressing the pro-resolving phenotype of peripheral innate immunity following traumatic brain injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Traumatic Head and Spine Injury

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative: The proposal examines the molecular basis of injury-induced axon degeneration and regeneration. In particular, we examine the regulation and function of a universal hallmark of neuronal degeneration, axonal spheroids. If successful, this work will inform therapies for a range of neurodegenerative disorders (e.g. Alzheimer’s, Parkinson’s, Luo Gehrig’s Disease) and injury (e.g. spinal cord injury, stroke, traumatic brain injury).

PI_NAMEs: DEPPMANN, CHRISTOPHER D (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;autocrine;Axon;axon regeneration;axonal degeneration;Biochemical;Biogenesis;Biological Assay;Calcium;Calpain;Caspase;Catabolism;Cessation of life;Chronic;Coculture Techniques;Cues;Cytokine Signaling;deprivation;Development;Disparate;Eating;Event;experimental study;Family member;gain of function;Growth;Huntington Disease;Impairment;in vivo;in vivo regeneration;Infiltration;inhibitor;injured;Injury;Kinetics;loss of function;Macrophage;MAPK8 gene;Microfluidic Microchips;Microfluidics;Modeling;Molecular;Morphology;mouse genetics;Movement;multicatalytic endopeptidase complex;Mus;mutant;Mutant Strains Mice;Natural regeneration;Nerve Crush;Nerve Degeneration;nerve injury;Nervous System;nervous system development;Neurodegenerative Disorders;neurological pathology;neuron loss;Neurons;neuropathology;Neurosciences;Nicotinamide adenine dinucleotide;novel;paracrine;Parkinson Disease;Pathologic;Pathway interactions;Phagocytes;pharmacologic;Phase;Phenotype;Phosphatidylserines;Positioning Attribute;preservation;prevent;programs;Property;receptor;recruit;Regenerative capacity;Regulation;response;response to injury;rho;Role;Rupture;sciatic nerve;Signal Pathway;Signal Transduction;spheroids;Spinal cord injury;Stroke;Structure;Swelling;targeted treatment;Techniques;Therapeutic;Therapeutic Intervention;Translations;Traumatic Brain Injury;Tumor Necrosis Factor Receptor;Wallerian Degeneration;wasting;Wild Type Mouse;Withdrawal;Work

PROJECT_TITLE: Extrinsic Mechanisms Governing Injury-Induced Axon Degeneration

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases;West Nile Virus;Zika Virus

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: Project Narrative: Flaviviruses are worldwide endemic human pathogens. Despite effective vaccines for some of these viruses, these viruses frequently cause human death. The proposed work will develop specific inhibitors against essential viral enzymes encoded by these viruses.

PI_NAMEs: LI, HONGMIN  (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: 3-Dimensional;Adverse effects;analog;Animal Model;Annual Reports;Anti-viral Agents;anti-viral efficacy;Anti-viral Therapy;Arbovirus Encephalitis;Binding;Biochemical;Biochemistry;Biological Assay;candidate validation;Cells;Cellular Assay;Cessation of life;Chemicals;Child;combat;Country;Crystallography;cytotoxicity;Dengue Infection;Dengue Vaccine;Dengue Virus;design;Development;Disease;Disease Outbreaks;drug candidate;Drug Kinetics;drug testing;Effectiveness;Enzymes;Epidemic;Flavivirus;Flavivirus Infections;Fluorescence;Fluorescence Resonance Energy Transfer;Genome;genomic RNA;high throughput screening;Human;Human Cell Line;human pathogen;In Vitro;in vivo;inhibitor;Innate Immune Response;innovation;Insecta;insight;Investigation;Japanese encephalitis virus;Label;Lead;lead candidate;lead optimization;Methods;Methylation;Methyltransferase;Microcephaly;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;nanomolar;Newborn Infant;novel;Organoids;Patients;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Poison;Populations at Risk;Positioning Attribute;Prevention;Public Health;Research;Research Personnel;Resources;Risk;RNA;RNA Caps;RNA replication;scaffold;screening;Serotyping;small molecule inhibitor;structural biology;Structure;Structure-Activity Relationship;synergism;Testing;Therapeutic;Therapeutic Agents;tool;Vaccination;vaccine hesitancy;Vaccines;Viral;viral genomics;Viral Physiology;virology;Virus;Virus Diseases;Virus Replication;West Nile virus;Work;Yellow Fever Vaccine;Yellow fever virus;Yellow Fever Virus Infection;Zika Virus;ZIKV infection

PROJECT_TITLE: Development of Inhibitors Targeting Flavivirus Methyltransferase

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(82)]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: Los Angeles

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Pontocerebellar Hypoplasia Type 1b (PCH1b) is a devastating inherited neurological disorder that preferentially affects specific regions of the brain, the pons and the cerebellum, causing children born with this condition to have dramatically reduced lifespans. The mutations that cause PCH1b occur in a gene that encodes a critical component of a molecular machine that is important for the regulation of gene expression. The proposed studies exploit the fruit fly (Drosophila) as a model system to provide insight into molecular mechanisms underpinning PCH1b.

PI_NAMEs: MORTON, DERRICK  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Affect;Alleles;Amino Acid Substitution;Amino Acids;Atrophic;Attention;autosome;Behavior;behavioral phenotyping;Biochemical;Biological;Biological Models;Biology;Biophysics;Brain;brain morphology;Brain region;Breathing;Catalytic Domain;CCRL2 gene;Cell model;Cell Nucleus;Cells;Cerebellum;Child;Childhood;Clinical;Complex;CRISPR/Cas technology;Cytoplasm;Data;Defect;Development;Developmental Delay Disorders;Disease;dosage;Drosophila genus;Enhancers;Etiology;exosome;Fishes;fly;gene editing technology;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;Genetic Screening;Genotype;Goals;Heterogeneity;Homeostasis;Homologous Gene;Human;Impairment;In Situ;in vivo;in vivo Model;Individual;Inherited;insight;Life;life span;Link;Mass Spectrum Analysis;Methods;Microcephaly;Missense Mutation;Modeling;Molecular;Molecular Machines;Motor;motor behavior;motor learning;Movement;Muscular Atrophy;mutant;Mutation;Nervous System;Nervous System Disorder;neurodevelopment;Neurodevelopmental Disorder;Neuronal Dysfunction;Neurons;novel;palliative;Pancreatic ribonuclease;Pathology;Phenotype;Play;Pontine structure;Pontocerebellar hypoplasia;Post-Transcriptional Regulation;Post-Transcriptional RNA Processing;Reporting;Ribonucleases;RNA;RNA Decay;RNA Processing;Role;sensory system;Sequence Deletion;Series;Severities;single-cell RNA sequencing;Spinal Cord;System;Technology;Testing;Tissues;tool;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Variant;Work

PROJECT_TITLE: Investigating RNA dysregulation in Neurological Disease through study of Pontocerebellar Hypoplasia Type 1b

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Genetics;Nutrition;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: NARRATIVE IgE-mediated food allergy affects 1 in 13 children in the USA. There is no FDA-approved treatment, and allergen immunotherapy treatments are not disease modifying in most patients. The maintenance of allergen- specific IgE, and allergen-specific T cells that support IgE, are poorly understood. We propose to study the maintenance of allergen-specific T cells and their role in IgE class switch in blood, lymph nodes, and mucosal tissues from individuals with IgE-mediated food allergy. Outcomes of this work will support the generation of immunotherapy approaches that alter the course of disease.

PI_NAMEs: BERIN, CECILIA  (contact);CUROTTO DE LAFAILLE, MARIA A

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Address;Affect;Affinity;Allergen Immunotherapy;Allergens;Allergic;Allergy to eggs;Allergy to peanuts;Antibodies;Antigens;B-Lymphocyte Subsets;B-Lymphocytes;Biopsy;Blood;BLR1 gene;CD4 Positive T Lymphocytes;Cell Compartmentation;Cell Maintenance;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Child;Circulation;Cues;cytokine;design;Disease;Duodenum;effector T cell;FDA approved;Flow Cytometry;Food;food allergen;food challenge;Food Hypersensitivity;Functional disorder;gastrointestinal;Generations;Half-Life;Heterogeneity;high dimensionality;Human;IgE;IL4 gene;IL5 gene;IL9 gene;Immunoglobulin A;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin M;Immunotherapy;Impairment;In Vitro;Individual;Interleukin-13;interleukin-13 receptor;Interleukin-4;Intervention;Intestines;Location;lymph nodes;Lymphoid Tissue;Maintenance;Mediating;Memory;Memory B-Lymphocyte;Mucous Membrane;Mus;neutralizing antibody;omalizumab;Oral;Outcome;Outcomes Research;pathogen;Pathogenicity;Patients;peripheral blood;Phenotype;Plasma Cells;Population;Production;Quality of life;Regulation;Regulatory T-Lymphocyte;Research;response;Role;Signal Transduction;single-cell RNA sequencing;Site;Source;Specimen;Supporting Cell;System;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Th2 Cells;therapeutic target;Time;Tissues;TNFSF5 gene;Tonsil;Up-Regulation;Work

PROJECT_TITLE: Heterogeneity of T cell phenotype and function in food allergy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Lifestyle interventions including physical activity appear to confer important protections to the brain that may delay the onset of symptoms of dementia. Dance movement is a form of physical activity that is promising as a potential activity to help maintain brain health, because it improves cardiorespiratory fitness and balance while providing cognitive challenge and social engagement, all important for maintaining brain health. This proposal seeks to fill key gaps in our basic understanding about the effects of the number of times per week people engage in dance movement on cardiorespiratory fitness and cognition that are essential for planning larger, definitive trials.

PI_NAMEs: HUGENSCHMIDT, CHRISTINA E (contact);SORIANO, CHRISTINA T

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: acceptability and feasibility;Adherence;Adult;Aerobic;Aerobic Exercise;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;artist;Behavior;behavior change;Behavioral;Brain;brain health;brain volume;Brain-Derived Neurotrophic Factor;cardiorespiratory fitness;Caring;Cognition;Cognitive;cognitive benefits;cognitive enhancement;Communities;comparison control;Dance Therapy;Dancing;Data;Dementia;Drops;Educational process of instructing;Epidemiology;Equilibrium;Exercise;exercise intervention;exercise physiologist;experience;fall risk;fitness;Frequencies;Funding;Health;Heart Rate;human old age (65+);Image;Impaired cognition;improved;Individual;Intervention;intrinsic motivation;Knowledge;Leisures;lifestyle intervention;Magnetic Resonance Imaging;Measures;Mediator;Methods;Modeling;motor learning;Movement;Music;Neurocognitive;neuroimaging;Nonpharmacologic Therapy;older adult;Outcome;Outcome Assessment;Outcome Measure;Persons;phase III trial;Physical activity;Physical Function;Populations at Risk;primary outcome;programs;Psychologist;psychosocial;Questionnaires;Randomized, Controlled Trials;Recording of previous events;recruit;Research;Research Personnel;response;Risk;Running;Sample Size;satisfaction;secondary outcome;Self Efficacy;Serum;social;social engagement;Social Interaction;Specificity;Structure;Symptoms;Testing;theories;Time;treadmill;trial design;United States National Institutes of Health;Walking;white matter;Work

PROJECT_TITLE: Establishing the optimal  frequency of dance movement for neurocognitive and physical outcomes in people at risk of Alzheimer's disease


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: We aim to develop a quantitative risk model for oral cavity cancer patients, 25-37% of whom will experience debilitating post-treatment recurrence. Using state-of-the-art machine learning and artificial intelligence methods, we will develop and validate our risk model on a large multi-site cohort of patients, and develop an AI-assisted synoptic report-filling tool for integrating into clinical practice. A computational pathology approach to characterizing disease will help identify patients for whom aggressive multimodality therapy will improve outcomes and post-treatment quality of life.

PI_NAMEs: DOYLE, SCOTT  (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: Active Learning;Address;Aftercare;Aggressive behavior;Algorithms;analysis pipeline;angiogenesis;Architecture;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence method;Biological Markers;Blinded;Cancer Patient;cancer recurrence;cancer type;Cessation of life;Clinical;clinical application;clinical practice;Clinical Trials;cohort;Collection;Combined Modality Therapy;Communities;Companions;computational pipelines;Consensus;Country;Data;Databases;deep learning;design;digital;digital pathology;Disease;Elements;Engineering;Evaluation;Excision;expectation;experience;experimental study;feature extraction;Foundations;Future;Goals;Head and neck structure;Head and Neck Surgery;high risk;Histologic;Image;imaging biomarker;Immune response;improved;improved outcome;innovation;international center;Link;Machine Learning;malignant mouth neoplasm;Malignant Neoplasms;Manuals;Maps;Medical Economics;Microscope;Modeling;novel strategies;Operative Surgical Procedures;Oral Stage;Outcome;outcome prediction;Pathologist;Pathology;pathology imaging;Pathology Report;Patients;Pattern;Performance;Play;Postoperative Period;predictive modeling;pressure;Productivity;Prognosis;prognostic value;prognostication;quality assurance;Quality of life;quantitative imaging;Radiation therapy;Randomized;Recommendation;Recurrence;Reporting;Reproducibility;Research;Resources;Risk;risk prediction;risk prediction model;Salvage Therapy;screening;Screening procedure;segmentation algorithm;Semantics;Site;Slide;Specimen;Standardization;Structure;Surgical Pathology;System;Testing;Time;tissue mapping;Tissues;tool;Training;Treatment Efficacy;treatment planning;tumor;uptake;Validation;Work;Workload

PROJECT_TITLE: A Quantitative Risk Model for Predicting Outcome and Identifying Structural Biomarkers of Treatment Targets in Oral Cancer on a Large Multi-Center Patient Cohort

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Genetics;Human Genome;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Pulmonary Fibrosis;Rare Diseases;Rheumatoid Arthritis

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE The overall goal of this proposal is to understand how the gain-of-function MUC5B promoter variant affects transcriptional regulation and gene expression that are common to clinically distinct types of usual interstitial pneumonia (UIP). The end-result will be an enhanced understanding of the novel genes, regulatory pathways and networks, and molecular mechanisms involved in disease etiology, launching investigation of novel pathogenic mechanisms and drug targets for these incurable diseases.

PI_NAMEs: SCHWARTZ, DAVID ALBERT (contact);YANG, IVANA V

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;Affect;airway epithelium;Antigens;Asbestosis;ATAC-seq;Binding;Biological;Biological Assay;Biology;Cell Nucleus;cell type;Cells;Characteristics;Chromatin;Chronic;Clinical;combinatorial;Complication;Data;Development;Disease;disease phenotype;Distal;Dominant Genetic Conditions;Drug Targeting;Elements;endoplasmic reticulum stress;Enhancers;Epigenetic Process;epigenetic regulation;Epithelium;Etiology;Exposure to;Extrinsic allergic alveolitis;Fibroblasts;Fibrosis;gain of function;Gene Expression;Gene Expression Profile;gene regulatory network;Genes;genetic risk factor;Genetic Transcription;genetic variant;Genotype;Goals;Heterogeneity;idiopathic pulmonary fibrosis;Immunohistochemistry;In Situ Hybridization;In Vitro;indexing;Individual;Interstitial Lung Diseases;Interstitial Pneumonia;Investigation;Lung;Lung Diseases;Methods;Methylation;Molecular;Molecular Profiling;Morphology;MUC5B gene;multiple omics;novel;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Phenotype;promoter;Publishing;Pulmonary Fibrosis;Quantitative Trait Loci;radiological imaging;Regulator Genes;Regulatory Pathway;Reporting;Research;Rheumatoid Arthritis;Risk Factors;risk variant;single nucleus RNA-sequencing;Structure of parenchyma of lung;Testing;transcription factor;Transcriptional Regulation;Transposase;Usual Interstitial Pneumonia;Variant

PROJECT_TITLE: Molecular Determinants of Usual Interstitial Pneumonia (UIP)

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Nanotechnology;Orphan Drug;Radiation Oncology;Rare Diseases

PHR: Project Narrative The proposed HNSCC tumor hallmark targeting and transformable nano-theranostics offer great promise in effectively overcoming the sequential biological barriers for significantly improved imaging sensitivity/specificity and drug delivery efficiency to HNSCC. They have tremendous potentials to be used in precision image-guided treatment for effective detection and elimination of early HNSCC lesions, particularly the aggressive subtypes. The team of experts in head and neck surgical oncology (Dr. Farwell) and medical oncology (Dr. Lam) as well as veterinary surgical oncology (Dr. Steffey) will provide comprehensive clinical expertise to facilitate the clinical development of the proposed novel transformable nano-theranostics that will ultimately benefit many patients with HNSCC.

PI_NAMEs: LI, YUANPEI  (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: Acidosis;Acids;Advanced Development;Affinity;Alcohol consumption;anti-cancer;Biodistribution;Biological;Blood Circulation;cancer cell;Cell Line;Charge;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical development;Communication;companion animal;cost effective;Crosslinker;Data;Detection;Development;Dose;Doxorubicin;Drug Delivery Systems;Early Diagnosis;Epstein-Barr Virus Infections;Excision;extracellular;Family Felidae;FDA approved;Felis catus;Fluorescence;fluorescence imaging;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Head and Neck Surgery;Human;Human papilloma virus infection;Image;image guided;image guided intervention;image visualization;image-guided drug delivery;imaging agent;Immunotherapy;improved;In Vitro;in vivo;Infiltration;innovation;Knowledge;Lesion;Ligands;Light;Lighting;Magnetic Resonance Imaging;Malignant - descriptor;malignant mouth neoplasm;Malignant neoplasm of nasopharynx;Malignant Neoplasms;malignant oropharynx neoplasm;Medical Oncology;Modality;Modeling;Monitor;mouse model;mouth squamous cell carcinoma;Multimodal Imaging;nano;nanotechnology platform;nanotheranostics;Nature;Near-infrared optical imaging;next generation;Normal tissue morphology;novel;Operative Surgical Procedures;optical imaging;patient derived xenograft model;Patients;Penetration;Permeability;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase I Clinical Trials;pheophorbide a;Photosensitizing Agents;Phototherapy;photothermal therapy;Physiological;Porphyrins;premature;Process;Prognosis;Property;Publishing;PUVA Photochemotherapy;Radiation therapy;Recurrence;Residual Neoplasm;response;Risk Factors;Sensitivity and Specificity;Signal Transduction;Site;spatiotemporal;Stimulus;Structure;subcutaneous;Surface;Surgical margins;Surgical Oncology;temporal measurement;theranostics;Therapeutic;Therapeutic Effect;Therapeutic Index;Therapeutic Use Study;Tissues;Tobacco use;Toxic effect;Translating;translational barrier;tumor;uptake;Veterinary Surgery;Virus Diseases;Visualization;Xenograft Model

PROJECT_TITLE: Tumor-penetrating nano-theranostics for image-guided interventions in spontaneous feline head and neck cancer

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Disability Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention;Rehabilitation;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative: We know that as we age, there is an increased risk of obtaining certain diseases such as vision impairment, dementia, and stroke. Preliminary evidence suggests that visual impairment is associated with post-stroke dementia and cognitive impairment. Investigating the specific types of vision impairment that influence the stroke-dementia relationship as well as the causes, may improve best methods for early diagnosis, preventative strategies, or specific services for this vulnerable population.

PI_NAMEs: HREHA, KIMBERLY PATRICE (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Address;Advanced Development;Age;Age related macular degeneration;Atherosclerosis Risk in Communities;Award;career development;Career Mobility;Characteristics;Clinic;Clinical;Clinical assessments;Clinical Research;Cognitive;cohort;Communities;Community Participation;Complex;Data;Data Set;Dementia;dementia risk;depressive symptoms;Development;direct application;Disease;Early Diagnosis;Educational workshop;Enrollment;Epidemiology;experience;Eye diseases;Functional impairment;functional independence;functional status;Funding;Future;Goals;Health;Health Services Research;Impaired cognition;improved;Individuals with physical disabilities;innovation;insight;Intervention;Knowledge;leadership development;Learning;longitudinal analysis;Mediating;Medical center;meetings;Mental Depression;Mental Health;Mentors;Mentorship;Methods;Minority Groups;Neurologic;Neuropsychology;novel;Occupational Therapist;Outcome;Persons;Population;post stroke;post stroke dementia;Prevalence;Prevention strategy;Productivity;programs;prospective;psychologic;rehabilitation research;Research;Research Activity;Research Methodology;Research Personnel;Research Proposals;Risk;Services;skill acquisition;skills;Statistical Data Interpretation;Stroke;stroke survivor;Surveys;symptomatology;Testing;Training;Training Activity;Vision;Visual;Visual impairment;Vulnerable Populations;Work

PROJECT_TITLE: Influence of Vision Impairments on Dementia in Stroke Survivors: A Longitudinal Analysis

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Differentiated service delivery (DSD) is an evidence-based implementation strategy to improve retention in care and viral suppression for people living with HIV in resource-constrained settings. The proposed project seeks to develop a DSD model for PMTCT that is user-centered and designed to enhance retention and viral suppression in the PMTCT population. Thus, the proposed project is relevant to the NICHD’s high-priority research focus on adverse pregnancy and infant outcomes related to prevention and treatment of HIV, as well as the broader mission of the NIH to seek fundamental knowledge to enhance health and reduce disability.

PI_NAMEs: HUMPHREY, JOHN M (contact)

PROGRAM_OFFICER_NAME: DEYAMPERT, TARA LYNN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;adverse pregnancy outcome;Affect;Africa;antenatal;antiretroviral therapy;Applied Research;Breastfed infant;career;career development;Caring;Client;Clinic;Clinical;clinical infrastructure;Communicable Diseases;Complex;contextual factors;Data;data integration;Databases;design;Development;disability;Eastern Africa;Educational workshop;Epidemiology;Evaluation;evidence base;experience;experimental study;follow-up;Goals;Guidelines;Health;health care availability;HIV;Horizontal Disease Transmission;human centered design;Human immunodeficiency virus test;implementation evaluation;implementation framework;implementation outcomes;Implementation readiness;implementation research;implementation strategy;improved;improved outcome;Individual;infant outcome;Internal Medicine;International;Kenya;Knowledge;Literature;male;Maternal and Child Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;Mission;Modeling;Morbidity - disease rate;mortality;Mother-to-child HIV transmission;National Institute of Child Health and Human Development;organizational readiness;Outcome;patient oriented;Patient Preferences;Pediatrics;Persons;Population;Positioning Attribute;Postpartum Period;Postpartum Women;Practical Robust Implementation and Sustainability Model;preference;Pregnancy;Pregnant Women;Prevention;Prevention therapy;programs;Provider;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Priority;Resource-limited setting;Risk;service delivery;Service delivery model;Services;Shapes;skills;Southern Africa;stakeholder perspectives;Time;Training;transmission process;United States National Institutes of Health;Viral;Woman;World Health Organization

PROJECT_TITLE: Adaptation, execution, and evaluation of a differentiated service delivery model for PMTCT


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases

ORG_NAME: ACCELEVIR DIAGNOSTICS, LLC

PHR: PROJECT NARRATIVE  For HIV-1 infected individuals on suppressive antiretroviral therapy, latent HIV-1 infection of resting memory CD4+ T cells is the major barrier to a cure. Elimination of these latently infected cells by is being pursued as a strategy to cure the infection. This proposal details the establishment of a centralized NIAID resource which will provide qualified assays to accurately quantify latent and expressed HIV reservoirs in research and clinical trials samples from the research community.

PI_NAMEs: LAIRD, GREGORY MICHAEL (contact);MARTIN, ALBINE

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Adoption;Anti-Retroviral Agents;antiretroviral therapy;assay development;Binding;Biological Assay;Blood specimen;Blood Volume;Businesses;CD4 Positive T Lymphocytes;Cells;CLIA certified;Clinical;Clinical Trials;Communities;cost;cost effective;curative treatments;Data;Dedications;design;Development;Diagnostic;Disease remission;DNA;Fees;Frequencies;Funding;Genetic Transcription;Grant;HIV;HIV-1;Immune;immune clearance;Immune system;improved;Individual;Industry;Infection;Infrastructure;innovation;Integrase;Laboratories;Laboratory Research;Left;Life;Location;Measurement;Measures;memory CD4 T lymphocyte;Molecular;National Institute of Allergy and Infectious Disease;novel therapeutic intervention;operation;particle;Performance;peripheral blood;Pharmaceutical Preparations;Poly A;Population;Procedures;programs;Protocols documentation;Proviruses;Qualifying;R24;Reagent;reagent testing;Recovery;Reporting;Reproducibility;Research;Research Personnel;research study;Residual state;Resources;Rest;Retroviridae;RNA;Sampling;Services;Shock;side effect;Standardization;success;System;Testing;testing services;therapeutic target;Time;Tissue Sample;Tissues;Treatment Efficacy;United States National Institutes of Health;Viral;Viral Load result;Viral reservoir;Viremia;Virus

PROJECT_TITLE: Centralized Resource to Accurately Quantify Latent and Expressed HIV Reservoirs


NIH_SPENDING_CATS: Transplantation

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Liver transplantation improves the quality of life and may be lifesaving for patients with end-stage liver disease, but improved outcomes for pre- and post-transplant patients requires better therapies and assessments of clinical outcomes, improved donor availability and increased access to medical care. The long-term objective of the Transplant Surgery Scientist Training Program, consistent with that of the Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32), is to train the next generation of physicians – especially surgeons - and scientists who can leverage scientific advances across many academic disciplines to advance the field of transplantation through team science. By fostering and supporting the training of inter-disciplinary liver transplant-related research, we can improve the health of patients with liver diseases, consistent with the mission of NIDDK.

PI_NAMEs: GREEN, RICHARD M (contact);LADNER, DANIELA P

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE