ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: IOWA CITY

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative A group of collagen-degrading enzymes present in dentin is suggested to be responsible for tissue breakdown that advances caries lesions, but the real contribution of these enzymes to disease progression and how their expression and activity is modulated are unclear. This study will fill major gaps in the understanding of endogenous processes in caries progression and provide insights into interactions between the microbiome present at different stages of the disease with host responses that express and/or activate dentinal enzymes. The information gained will provide the foundation for the development of novel therapies for caries management to promote a shift from invasive surgical restorative to conservative reparative treatments, while at the same time contributing to a much deeper understanding of the microbiome-host interactions in caries disease.

PI_NAMEs: DE MATTOS PIMENTA VIDAL, CRISTINA  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Adult;Age;Award;Bacteria;Binding;Biochemical;Bioinformatics;Biology;career development;cariogenic bacteria;Cells;Clinical;collagenase;Communication;Complex;cost;Data;demineralization;Dental;Dental caries;Dental Enamel;Dental Pulp;Dentin;Dentin Formation;Dentistry;design;Development;Diet;dietary;Disease;Disease Progression;effective therapy;Ensure;Environment;Enzyme Activation;Enzymes;Esthetics;Etiology;Excision;experience;experimental study;Extracellular Matrix;Filtration;Foundations;Future;Gene Expression;Genetic;Genomics;Goals;Health;host microbiome;Immune response;In Vitro;in vivo;Infiltration;innovation;insight;Interdisciplinary Study;Knowledge;Leadership;Left;Lesion;Maps;Mediating;member;Mentors;Mentorship;Metalloproteases;Methodological Studies;microbial composition;Microbiology;microbiome;microorganism;mineralization;Minerals;Modeling;National Health and Nutrition Examination Survey;new therapeutic target;novel;novel therapeutics;Odontoblasts;Operative Surgical Procedures;Oral;oral microbiome;Pathology;Pattern recognition receptor;Peptide Hydrolases;permanent tooth;Population;prevent;Process;Property;protein expression;Proteinase-Activated Receptors;Proteins;Proteomics;Publications;remineralization;repaired;reparative process;Research;Research Personnel;Research Support;Resources;restoration;Role;Salivary;Scientist;screening;skills;sound;stem cells;Structure;Testing;Time;tissue repair;Tissues;Tooth Loss;Tooth structure;Training;Undifferentiated;United States;Writing;young adult

PROJECT_TITLE: Modulation of MMPs gene expression and activity by the microbiome in caries

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: MD

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN JUAN

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: Project Narrative – Community Engagement Core See Overall Section, as per RFA MD-22-002 instructions.

PI_NAMEs: VELEZ VEGA, CARMEN M (contact)

PROJECT_TERMS: Address;Area;Award;Collaborations;Communities;community academic partnership;community based practice;community based research;community collaboration;community engaged approach;community engagement;community organizations;Community Outreach;Community Participation;community partners;community partnership;Competence;cultural competence;design;Development;Directories;Education;Educational Activities;Educational Materials;Educational workshop;Evaluation;Exposure to;Feedback;Fostering;Funding;Geography;Goals;Health;health disparity;health literacy;health organization;Health Promotion;improved;Infrastructure;Institution;Instruction;interest;Knowledge;meetings;Methodology;Methods;minority health;minority health disparity;Needs Assessment;Participant;Process;Puerto Rico;recruit;Recurrence;Reduce health disparities;Research;Research Personnel;Research Project Grants;Series;social media;statistics;Students;Surveys;symposium;Translating;Translational Research;Work;Writing

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Networking and Information Technology R&D (NITRD);Neurosciences;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

PHR: Project Narrative – Research Capacity Core See Overall Section, as per RFA MD-22-002 instructions.

PI_NAMEs: ROCHE-LIMA, ABIEL  (contact)

PROJECT_TERMS: Address;Administrator;Area;bioimaging;Bioinformatics;biomedical data science;Biomedical Research;Biometry;Caribbean region;chikungunya;Clinical Research;Collaborations;Communicable Diseases;community engagement;Comprehensive Cancer Center;Computational Technique;Computer software;confocal imaging;cost;COVID-19 pandemic;Data;Data Science;Dengue;Development;Electronics;Elements;Emerging infection;emerging tropical infectious disease;Endowment;Evaluation;Experimental Designs;Faculty;Funding;Genomics;Goals;health data;health disparity;Health Services Research;heterogenous data;High Performance Computing;Hispanic;HIV;Image;imaging facilities;Infectious Diseases Research;Informatics;Infrastructure;Institution;Instruction;instrumentation;laboratory equipment;Lead;Learning;Medical;medical schools;Methods;Molecular;National Institute of General Medical Sciences;National Institute on Minority Health and Health Disparities;Nervous System Physiology;Neurobiology;neurogenetics;operation;pandemic disease;pathogen;Pilot Projects;Productivity;programs;Proteomics;Public Health Informatics;Puerto Rico;Recovery;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;Research Project Summaries;Research Training;Resources;Schedule;Science;Scientist;Secure;Service provision;Services;Shapes;Specialist;Structure;synergism;System;Time;Training;Translational Research;trend;Wages;ZIKA

PROJECT_TITLE: Research Capacity Core


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Lung;Pulmonary Hypertension;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative One of the common complications of pulmonary hypertension is right-sided heart failure that is associated with poor prognosis in patients. We have developed preliminary data showing that right-sided heart failure, in part, is mediated by excessive activation of cardiac fibroblasts induced by the specific enzyme named protein kinase D. This research will allow us to design a novel strategy for the management of right-sided heart failure during pulmonary hypertension.

PI_NAMEs: JHUN, BONG SOOK  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Antioxidants;Apoptosis;Apoptotic;Attenuated;Bax protein;Calcium;Cardiac;Cardiac Myocytes;Cause of Death;Cell Membrane Permeability;Cell Nucleus;Chronic;Clinical;Collagen;conventional therapy;coronary fibrosis;Cyclic AMP-Dependent Protein Kinases;Data;design;Development;Dominant-Negative Mutation;Dynamin;Enzymes;Extracellular Matrix;Failure;Fibroblasts;Fibrosis;Functional disorder;Goals;improved;in vivo;Injury;interstitial;Left;Link;Mediating;Mitochondria;mitochondrial permeability transition pore;Mitochondrial Proteins;Modeling;Molecular;mortality;Myofibroblast;Names;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Nuclear;Nuclear Proteins;Outcome;Outer Mitochondrial Membrane;Pathologic;Patients;Phenotype;Phosphorylation;Physiologic intraventricular pressure;pre-clinical;pressure;pro-apoptotic protein;Process;Prognosis;Proliferating;Protein Inhibition;protein kinase D;Proteins;pulmonary arterial hypertension;Pulmonary Hypertension;Rattus;Reactive Oxygen Species;Reporting;Research;Resistance;response;response to injury;right ventricular failure;Right Ventricular Function;Right Ventricular Hypertrophy;Role;Signal Transduction;Stress;Testing;therapeutic evaluation;uptake;Ventricular

PROJECT_TITLE: Mitochondrial Fission, Calcium, ROS in Right Ventricular Fibrosis

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative Human Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent for Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. We discovered that KSHV exploits an innate immune kinase to promote the proliferation of KSHV- infected PEL cells. This study will develop small molecule inhibitors to target the innate immune kinase, thus impeding the proliferation of KSHV-infected PEL cells.

PI_NAMEs: FENG, PINGHUI  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;anti-viral efficacy;Anti-viral Therapy;Basic Science;Binding;cancer cell;Cell Proliferation;Cells;Cellular Metabolic Process;chronic infection;Citric Acid Cycle;clinical application;Coupling;deamidation;drug-like compound;effective therapy;efficacy evaluation;Enzymes;Episome;Etiology;Event;G1 Phase;gammaherpesvirus;Genome;Glutamine;Herpesviridae;Herpesviridae Infections;Human;Human Herpesvirus 4;Human Herpesvirus 8;IKKepsilon;Immune;Immune response;immunodeficient mouse model;Individual;insight;Integration Host Factors;interest;Interferons;Investigation;Kaposi Sarcoma;Knowledge;Lymphoma;Lymphoma cell;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Metabolic;Metabolism;Molecular;Morbidity - disease rate;mortality;Multicentric Angiofollicular Lymphoid Hyperplasia;neoplastic cell;novel;nucleotide metabolism;Oncogenic Viruses;organ transplant recipient;Outcome;pathogen;Patients;Phosphorylation;Phosphotransferases;Post-Translational Protein Processing;primary effusion lymphoma;programs;Proliferating;Protein-Serine-Threonine Kinases;Proteins;Purines;Pyrimidine;Research;Role;Serine;small molecule;small molecule inhibitor;System;targeted treatment;Testing;Thymidine Kinase;tumor;Tumor Biology;Tumor Cell Biology;tumor metabolism;Vaccines;Viral;Viral Physiology;virus host interaction;Work

PROJECT_TITLE: Targeting IKKepsilon-mediated nucleotide synthesis in KSHV-associated lymphoma

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Neurosciences;Physical Activity;Prevention;Rehabilitation

ORG_CITY: Boulder

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative Above-normal systolic blood pressure is a highly prevalent chronic condition that increases risk for cardiovascular diseases, stroke, cognitive decline/dementia, and other chronic disorders, due in part to blood pressure-associated vascular dysfunction mediated by increased oxidative stress and consequent reductions in nitric oxide (NO)-bioavailability. Healthy lifestyle practices are first-line therapies to lower systolic blood pressure; however, adherence to time-intensive lifestyle interventions is poor, due in large part to time- availability related barriers. This clinical trial seeks to establish the efficacy of high-resistance inspiratory muscle strength training, a novel time-efficient lifestyle intervention, for lowering systolic blood pressure; improving endothelial, cerebrovascular, and cognitive function; decreasing oxidative stress; and increasing NO bioavailability in adults age 50 years and older with above-normal systolic blood pressure.

PI_NAMEs: CRAIGHEAD, DANIEL HARRISON (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: Acute;Adherence;Adult;Aerobic Exercise;Age;aged;arterial stiffness;Ascorbic Acid;Biological Availability;Biomedical Research;Biopsy;Blood flow;Blood Flow Velocity;Blood Pressure;blood pressure elevation;blood pressure reduction;Blood Vessels;brachial artery;Canada;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Physiology;cardiovascular risk factor;career development;cerebral artery;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular Physiology;cerebrovascular reactivity;Chronic;Chronic Disease;Clinical;Clinical Trials;clinically relevant;Cognitive;cognitive enhancement;cognitive function;cognitive performance;Colorado;comorbidity;Conduct Clinical Trials;Data;Dementia;Development;Development Plans;Diastolic blood pressure;disorder risk;Doctor of Philosophy;Double-Blind Method;Dropout;efficacy evaluation;efficacy testing;Elasticity;Endothelial Cells;endothelial dysfunction;Endothelium;Environment;evidence base;experience;Extramural Activities;Faculty;Femur;Functional disorder;Funding;Goals;Guidelines;healthy lifestyle;Hour;Hypercapnia;Hypertension;hypertensive;Impaired cognition;improved;Infusion procedures;Inhalation;innovation;Internal carotid artery structure;International;Intervention;Journals;lifestyle intervention;Link;Mediating;Medical;Medicine;meetings;men;Mentors;middle cerebral artery;modifiable risk;Molecular;muscle strength;Nature;new epidemic;Nitric Oxide;novel;Obstructive Sleep Apnea;older adult;Oxidative Stress;Patients;Peripheral;Physiologic pulse;Physiology;pilot trial;Population;Postdoctoral Fellow;pressure;prevent;Process;Production;professor;programs;Proteins;Protocols documentation;Randomized Controlled Clinical Trials;Records;Research;Research Personnel;Research Priority;Research Project Grants;Research Training;Resistance;response;Rest;Risk;Scientist;seal;Secondary to;Serum;Signaling Molecule;skill acquisition;skills;Sodium-Restricted Diet;strength training;Stroke;Superoxides;Techniques;therapy development;Time;Training;treatment duration;United States;United States National Institutes of Health;Universities;Vascular Diseases;Vascular Endothelium;Woman;Work

PROJECT_TITLE: Novel time-efficient inspiratory muscle strength training for lowering systolic blood pressure and improving endothelial, cerebrovascular, and cognitive function

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Cancer

ORG_CITY: HERSHEY

ORG_DEPT: PEDIATRICS

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Narrative Autophagy, a cellular process of self-eating, plays a critical role in degrading and recycling cellular components by delivering them to the lysosome. Although dysregulated autophagy is recognized as a significant feature of cancer, effectively harnessing autophagy for optimal therapeutic benefits poses a challenge. This project aims to investigate a novel approach to induce alternative cell death signaling from autophagosomal membranes. The successful completion of this research holds the potential to reveal innovative strategies for cancer therapy.

PI_NAMEs: WANG, HONG-GANG  (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: 8p22;Address;Apoptosis;Autophagocytosis;Autophagosome;Biological Assay;Biological Process;cancer cell;cancer initiation;cancer therapy;cancer type;CASP8 gene;Cell Death;Cell Death Signaling Process;cell growth;Cell Physiology;Cell Survival;Cells;Cessation of life;chromosome 8p loss;clinically relevant;cofactor;Complex;CRISPR library;Cytokinesis;Defect;Degradation Pathway;Dependence;Development;Eating;Endosomes;Future;Gatekeeping;Genes;genome-wide;Homeostasis;Impairment;innovation;insight;Knowledge;Link;Liver;Lysosomes;Malignant Neoplasms;MAP3K7 gene;Maps;Mediating;Membrane;Modeling;Multivesicular Body;Mus;mutant;Mutate;N-terminal;NF-kappa B;novel;novel strategies;Nutrient;Organelles;Pathway interactions;patient prognosis;Phosphotransferases;Play;Positioning Attribute;Process;protein complex;Proteomics;Recycling;Research;Role;seal;Shapes;Signal Induction;Signal Pathway;Signal Transduction;Solid;Sorting;Stress;Testing;Therapeutic;tumor;Tumor Promotion;tumorigenesis;Ubiquitin;Up-Regulation;Variant;Vesicle

PROJECT_TITLE: Non-canonical Caspase-8 Activation on Autophagosomal Membranes

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: ROCHESTER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Transfer RNAs (tRNAs) are critical for decoding messenger RNA during translation by the ribosome, where they insert their charged amino acid into the end of the growing peptide chain. The numerous tRNA modifications found in all organisms are critical for function and stability, are highly conserved in the yeast Saccharomyces cerevisiae and in humans, and are required to prevent poor growth in yeast and human neurological disorders and mitochondrial diseases. This project is directed toward study of critical tRNA decay pathways in S. cerevisiae and the evolutionarily distant yeast Schizosaccharomyces pombe, and study of tRNA turnover dynamics in wild type cells and cells lacking critical modifications, to understand factors that influence the population of tRNAs.

PI_NAMEs: PHIZICKY, ERIC M. (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 7-methylguanosine;Address;Adenosine;Affect;Amino Acids;Amino Acyl-tRNA Synthetases;Anticodon;Biochemical;biological adaptation to stress;Biology;cell type;Cells;Charge;Complex;Defect;Disease;disease phenotype;Distant;Ensure;Eukaryota;exosome;Exposure to;Fission Yeast;flexibility;follow-up;Genetic;genetic selection;genome sequencing;Growth;Health;Histidine-Specific tRNA;Human;human disease;Impairment;Individual;insight;Isoleucine-Specific tRNA;Label;Leucine-Specific tRNA;Link;Location;Maps;Mass Spectrum Analysis;Messenger RNA;Metabolic;Mitochondrial Diseases;Modification;Molecular Biology;mutant;Mutation;Nervous System Disorder;Neurologic;Nuclear;nuclease;Organism;Pathway interactions;Peptides;Phosphodiesterase I;Population;posttranscriptional;prevent;Proteins;Pseudouridine;Rattus;Regulatory Pathway;repaired;Ribosomes;RNA Decay;RNA Processing;RNA Stability;Role;Saccharomyces cerevisiae;Site;Small Nuclear RNA;spleen exonuclease;temperature sensitive mutant;Transfer RNA;Translations;Variant;whole genome;Work;Yeasts

PROJECT_TITLE: tRNA Processing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-T (02)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric

ORG_CITY: PITTSBURGH

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative: We propose to develop and test a novel computer tool that can identify those who are diagnosed with orbital abscess and can benefit from early surgical drainage.

PI_NAMEs: FU, ROXANA  (contact);PU, JIANTAO

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: Abscess;Acute;Admission activity;Adult;Affect;Algorithms;Anatomy;Antibiotics;Artificial Intelligence;artificial intelligence algorithm;Automation;Biological Markers;Blindness;Brain;Cellulitis;Cessation of life;Characteristics;Child;Childhood;Clinical;clinical practice;Communities;Computational algorithm;Computer Models;Computers;Consumption;cost;Decision Making;Decongestants;demographics;design;Detection;Diagnosis;Drainage procedure;Emergency Situation;Ensure;Failure;Goals;healthcare burden;Healthcare Systems;high risk;Hour;Human;Image;improved;Infection;inpatient service;Inpatients;Institution;Intervention;Intravenous;Investigation;Journals;Length of Stay;Life;machine learning method;Manuals;Measures;Medical;Methods;Modeling;Morbidity - disease rate;mortality;multidisciplinary;novel;Operative Surgical Procedures;Ophthalmologist;Ophthalmology;Optic Nerve;Outcome;Patients;pediatric patients;Peer Review;Performance;predicting response;predictive modeling;prevent;Publishing;radiological imaging;Recommendation;Research;Research Personnel;response;Role;Sinus;Sinusitis;Site;spatial relationship;surgery outcome;Technology;Testing;therapy outcome;Time;tool;Treatment Efficacy;treatment guidelines;United States;Work;X-Ray Computed Tomography;X-Ray Tomography

PROJECT_TITLE: Automation of the radiographic surgical indicators for pediatric orbital abscess

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Despite the use of intensive multimodal therapy for high-risk neuroblastoma approximately 50% of children still die from this disease, survivors suffer life-long treatment related co-morbidities, and relapsed neuroblastoma is almost universally lethal. This research project is relevant to public health as it focuses on defining resistance mechanisms to chimeric antigen receptor (CAR) T cells targeting the robustly differentially expressed neuroblastoma cell surface oncoprotein glypican-2 and on developing next-generation CAR T cells that circumvent this resistance, studies that will be important for the field of cancer immunotherapy in general and the pediatric cancer neuroblastoma in particular. The proposed research is highly relevant to the NIH mission and urgent unmet medical need of developing rational evidence-based strategies to reduce the health burden of neuroblastoma and other cancers.

PI_NAMEs: BOSSE, KRISTOPHER R (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: adaptive immunity;Address;Affinity;Antibodies;Antigen Receptors;Antigen Targeting;Antigens;Back;bench to bedside;Binding;Bioinformatics;Biology;cancer immunotherapy;cancer therapy;CAR T cell therapy;Cell secretion;Cell surface;Cells;Cessation of life;Child;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Data;clinical translation;Clinical Trials;combat;Combined Modality Therapy;comorbidity;cytotoxicity;Data;density;design;Development;differential expression;Disease;Down-Regulation;Engineering;Enzyme Induction;evidence base;extracellular vesicles;first-in-human;Glypican;Goals;Health;high risk;Human;Immune;Immunocompetent;immunological synapse;Immunology;Immunotherapeutic agent;Immunotherapy;In complete remission;In Vitro;in vivo;innovation;insight;Interdisciplinary Study;Investigational New Drug Application;Laboratories;Link;Macrophage;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Mediator;Medical;Mission;mouse model;Mus;Natural Immunity;Natural Killer Cells;neoplastic cell;Neuroblastoma;neuroblastoma cell;new therapeutic target;next generation;Normal tissue morphology;Oncoproteins;Outcome;overexpression;patient derived xenograft model;Pediatric Hospitals;Peptidyl-Dipeptidase A;Phase I Clinical Trials;phase I trial;Phenotype;Philadelphia;Positioning Attribute;preclinical efficacy;pressure;prevent;Process;Public Health;Publishing;receptor;Relapse;Research;Research Project Grants;Resistance;resistance mechanism;Role;Safety;sialogangliosides;Signal Transduction;Survivors;synergism;T-Lymphocyte;Technology;Testing;Therapeutic;translational oncology;translational research program;Treatment Failure;treatment risk;tumor;Tumor Escape;United States National Institutes of Health;Up-Regulation;vesicular release

PROJECT_TITLE: GPC2 CARs in neuroblastoma: Mechanisms of resistance and efficacy of next-generation constructs

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Social Determinants of Health;Substance Misuse

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to both public health and NIH’s mission because developing a clear understanding of rules of controlled use of cannabis may lead to the policies and interventions that support safer use of cannabis in policy environments where cannabis is increasingly accessible and potent.

PI_NAMEs: LANKENAU, STEPHEN E (contact);WONG, CAROLYN FONG NAP

PROGRAM_OFFICER_NAME: KIMMEL, HEATHER L

PROJECT_TERMS: Address;Adherence;Adult;Age Years;Assessment tool;Automobile Driving;Baseline Surveys;Books;calcification;California;Cannabis;Characteristics;Clinical;cohort;Communities;Consumption;Controlled Study;Data;Data Set;Dependence;design;development policy;Disease;Ecological momentary assessment;emerging adult;Environment;Exhibits;Family;Funding;Goals;Grain;Health;Individual;insight;Intervention;Interview;Knowledge;Legal;Literature;Longitudinal cohort;Los Angeles;marijuana legalization;marijuana use;marijuana use disorder;marijuana user;Marketing;Measurement;Measures;Medical;Medical Marijuana;Mission;Modeling;novel;older adult;Outcome;Participant;Patients;Pattern;Pennsylvania;Persons;Pharmaceutical Preparations;Philadelphia;pilot test;Policies;Process;psychosocial;Public Health;Quality of life;Reporting;Research;Research Personnel;response;Risk;risk minimization;Ritual compulsion;Sampling;Scientific Advances and Accomplishments;Site;social;social stigma;Societal Factors;Stress;Surveys;Testing;Time;United States National Institutes of Health;Validation;Work;young adult

PROJECT_TITLE: Medical Marijuana, Emerging Adults, and Community: Connecting Health and Policy

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Alcohol use disorder is among the most common and severe major psychiatric disorders. This proposal seeks to combine AUD GWAS with gene expression and DNA methylation findings from a large cohort of postmortem brains and regions. This novel, integrated analysis will detail so far unknown AUD-associated genes and epigenetic marks and will allow identification of neurobiological mechanisms and novel therapeutic targets.

PI_NAMEs: GIRGENTI, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: GITIK, MIRI

PROJECT_TERMS: addiction;Adult;Affect;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol risk;alcohol use disorder;Alcohols;Amygdaloid structure;Anterior;Area;Autopsy;Biological;Biological Markers;Biology;bisulfite sequencing;Brain;Brain Diseases;Brain region;brain tissue;causal variant;Chronic;cingulate cortex;clinically significant;cohort;Communities;comparison control;Complex;Control Groups;Data;data resource;Data Set;Databases;Development;diagnostic development;differential expression;Disease;disorder risk;Dissection;DNA analysis;DNA Methylation;drinking;entorhinal cortex;Epigenetic Process;epigenetic variation;Etiology;Exons;functional genomics;Funding;Gene Expression;Genes;Genetic;Genetic Models;Genetic Transcription;genetic variant;Genetic Variation;genome wide association study;genome-wide;Genomic approach;Genomics;Genotype;Goals;Hippocampus;Human;Individual Differences;insight;Intervention;Lead;Letters;Link;Major Depressive Disorder;Medial;Mediating;Mental disorders;Methylation;methylation pattern;Molecular;molecular pathology;molecular phenotype;Molecular Profiling;Multiomic Data;multiple omics;neurobiological mechanism;neuroinflammation;neuropsychiatric disorder;new therapeutic target;nicotine use;novel;Nucleus Accumbens;Occupations;open source;Outcome;Outcomes Research;Pathway interactions;personalized therapeutic;Phenotype;polygenic risk score;Post-Traumatic Stress Disorders;potential biomarker;predictive modeling;Predisposition;Prefrontal Cortex;preventable death;Process;programs;Quantitative Trait Loci;Regulation;Research;Resources;Rewards;risk variant;Sampling;Synapses;Testing;therapeutic target;Tissues;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Translating;translational neuroscience;United States;Untranslated RNA;Variant;Veterans;whole genome

PROJECT_TITLE: Molecular Dissection of Alcohol Use Disorder Through Targeted Brain Multi-omics

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative Initial work in this project conclusively demonstrated the ability of contrast-enhanced ultrasound (CEUS) to detect residual viable hepatocellular carcinoma following transarterial chemoembolization significantly earlier and with improved sensitivity relative to the current clinical standard. We now seek to expand these findings to other solid tumors being treated with chemoembolization and to use advanced ultrasound imaging approaches to improve on the technique’s suboptimal specificity. Additionally, we plan to expand the role of CEUS by investigating intraoperative treatment assessment as well as pre-treatment assessment for guiding the selection of locoregional therapy.

PI_NAMEs: EISENBREY, JOHN  (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: 3-Dimensional;Adoption;Adsorption;Aftercare;Algorithms;American College of Radiology;Area;Arterial Embolization;Arteries;Blood;Blood flow;Blood Vessels;Catheters;Chemoembolization;Cholangiocarcinoma;Clinic;Clinical;Colorectal Cancer;contrast enhanced;Contrast Media;Data;detection sensitivity;Diagnostic;Diagnostic Procedure;Drug usage;Evaluation;feeding;follow-up;Frequencies;Funding;Grant;Guidelines;Image;Image Analysis;imaging agent;imaging approach;improved;In complete remission;Information Systems;Institution;Lead;Lesion;Liver;Liver Cirrhosis;liver imaging;Local Therapy;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant neoplasm of liver;Melanoma;Metastatic Neoplasm to the Liver;Microscopic;Modality;Morphologic artifacts;Morphology;Multicenter Trials;Neuroendocrine Tumors;participant enrollment;particle;Patients;Performance;Physicians;Prediction of Response to Therapy;preference;Primary carcinoma of the liver cells;prospective;Protocols documentation;Radioembolization;Recommendation;Reference Standards;Reporting;Residual Neoplasm;Residual state;Resolution;response;Retreatment;Role;Scanning;Selection for Treatments;Signal Transduction;Soft tissue sarcoma;Solid Neoplasm;Specificity;Spectrum Analysis;standard of care;Structure;Techniques;Therapeutic;Time;Transplantation;Treatment outcome;treatment response;tumor;Ultrasonography;ultrasound;United States National Institutes of Health;Vascular blood supply;Work;X-Ray Computed Tomography

PROJECT_TITLE: 2D and 3D Contrast-enhanced Ultrasound Evaluation of Chemoembolization.

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Mounting evidence suggests poor patient experiences with peripartum contraceptive care. Validated quality metrics grounded in patient-centeredness and health equity could help drive efforts to improve these crucial domains of healthcare quality, but no such measures currently exist. We will use modified Delphi methods with patient and expert stakeholders, cognitive interviews with patients, and psychometric testing to generate a novel measure of the patient experience of contraceptive counseling within the unique context of maternity care, with a goal of ultimately transforming the ability of health systems and researchers to understand and promote patient-centered, equitable peripartum contraceptive care delivery and thereby improve health outcomes for mothers and infants.

PI_NAMEs: MONIZ, MICHELLE HELENA (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;adverse birth outcomes;Advocate;Affect;birth control;Birth Intervals;Black race;Breast Feeding;care delivery;Caring;Childbirth;Clinical;cognitive interview;Consensus;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Counseling;Disparity;Ensure;Equity;Ethnic Origin;evidence base;experience;Factor Analysis;family building;Family Sizes;Feedback;Frequencies;Future;Goals;Health;health care quality;health disparity;health equity;Health system;Healthcare Systems;improved;Individual;individual patient;Inequity;Infant;innovation;Intervention;Justice;Latinx;Life Cycle Stages;marginalized population;Maternal and Child Health;maternal outcome;Measurement;Measures;Methods;Minority Groups;Monitor;Mothers;Nature;novel;Outcome;Outcome Measure;Paternalism;patient oriented;Patient Outcomes Assessments;Patient Preferences;Patients;Performance;Perinatal;Perinatal Care;person centered;Persons;Population;Population Heterogeneity;Postpartum Period;Pregnancy;pregnancy prevention;pregnant;Prenatal care;pressure;prospective;prototype;Provider;Psychometrics;Public Health;Quality of Care;Race;racism;Reporting;Reproduction;reproductive;Reproductive Health;Research Personnel;Respondent;Rice;Risk;Sampling;Stereotyping;Structure;Subgroup;Test Result;Testing;theories;Training;treatment planning;Trust;Validity and Reliability;Work

PROJECT_TITLE: Developing and Validating a Measure of Patient-centered Peripartum Contraceptive Care

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Primary Health Care;Racial and Ethnic Minority Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Dementia is a growing healthcare problem and a research priority, yet it remains under-recognized in the community, under-diagnosed by healthcare professionals, and under-coded in claims data. This study aims to address this pressing need by developing a deep learning algorithm to improve the detection of cognitive impairment within electronic medical records and conducting comprehensive validation across multiple healthcare institutions. The study will not only facilitate research but may also aid providers in planning and managing patient care.

PI_NAMEs: DAS, SUDESHNA  (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Active Learning;Address;adjudication;African American;algorithmic bias;Algorithms;Alzheimer disease detection;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Artificial Intelligence;Asian;Black American;burden of illness;Classification;Clinic;Clinical;Code;Cognition;Cognitive;Collaborations;Communities;Complex;computer scientist;Computerized Medical Record;Data;Data Element;Data Set;Databases;deep learning;deep learning algorithm;deep learning model;Dementia;demographics;Detection;Development;Diagnosis;diagnostic criteria;Electronic Health Record;Ensure;Entropy;Epidemiologist;Ethnic Origin;Evaluation;follow-up;Functional disorder;Geography;Health;Health Care Costs;health care settings;Health Professional;Health Sciences;Health system;Healthcare;Healthcare Systems;Hispanic;Hospitals;Impaired cognition;improved;Individual;innovation;Institution;Intervention;Knowledge;Label;large language model;Learning;learning algorithm;learning strategy;Measures;Memory;Methods;mild cognitive impairment;Minority Groups;Modeling;multidisciplinary;Natural Language Processing;Not Hispanic or Latino;Output;Patient Care Management;patient screening;Patients;Pattern;Performance;Pharmaceutical Preparations;Phenotype;Population;pragmatic trial;predictive modeling;Primary Care;primary care patient;Probability;Procedures;programs;prospective;Provider;Race;Recording of previous events;Reference Standards;Research;research clinical testing;Research Priority;research study;Sample Size;Sampling;screening;sex;Site;socioeconomics;Source;source localization;Specific qualifier value;Structure;structured data;Subgroup;success;Symptoms;Texas;Text;Training;Uncertainty;Universities;unstructured data;Validation;Wife;Wisconsin;Work

PROJECT_TITLE: A deep learning algorithm to detect signs of cognitive impairment in electronic health records


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Biotechnology;Chronic Pain;Osteoarthritis;Pain Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will provide new targets to advance therapies for the early treatment of injury-induced osteoarthritis (OA). Our study provides a novel perspective to study OA pathophysiology in which joints and muscles are both target tissues, and both contribute to the pain associated to this disease. We are proposing two novel drug delivery systems and two potential new therapeutic targets that could be beneficial to limit both joint and muscle damage involved in OA, as well as inflammation and pain, opening new critical insights to treatment.

PI_NAMEs: LONGOBARDI, LARA  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: absorption;Acute Pain;Address;Animal Model;Animals;antagonist;anterior cruciate ligament reconstruction;Binding;bone;bone metabolism;Cartilage;cartilage degradation;cartilage metabolism;CC chemokine receptor 2;CCL2 gene;Cells;chemokine;chemokine receptor;Chemotactic Factors;Chondrocytes;Chronic;chronic pain;Circulation;Clinical Research;Collagen;Complex;cost effective;cyanine dye 5;cytokine;Data;Degenerative polyarthritis;Deterioration;Disease;Dose;Drug Carriers;Drug Delivery Systems;Drug or chemical Tissue Distribution;drug testing;Dyes;Early treatment;efficacy testing;Event;folate-binding protein;Folic Acid;Functional disorder;Gene Deletion;Genes;Human;improved;in vivo;Infiltration;Inflammation;Inflammatory;Injury;innovation;insight;joint destruction;joint injury;Joints;Knee Osteoarthritis;Label;Ligands;Link;Literature;Macrophage;Macrophage Activation;Measures;Mediating;Methods;Modeling;Molecular;Monitor;Mus;Muscle;muscle strength;Muscle Weakness;Muscular Atrophy;Myalgia;new therapeutic target;novel;novel therapeutics;Osteoblasts;Osteoclasts;Pain;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;prevent;Proteins;Public Health;Publishing;quadriceps muscle;radiological imaging;Rattus;Reporting;Research;Role;Serum;Signaling Molecule;Site;Source;Structure;Symptoms;Synovial Membrane;Synovitis;Therapeutic;Therapeutic Effect;Therapeutic Studies;therapeutic target;Thick;Time;tissue degeneration;Tissues;Trauma;Traumatic Arthropathy;uptake;Work

PROJECT_TITLE: Role of CCR2 in osteoarthritis

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE- OVERVIEW The Indiana University Melvin and Bren Simon Cancer Center is an NCI-designated Cancer Center whose mission is to create an expanding community of researchers and health professionals who conduct outstanding translational research, provide excellence in education, and deliver high quality patient-centered care. We will foster and promote an environment of cultural awareness, diversity, and inclusion as we contribute to the prevention and cure of cancer in Indiana. We recognize social injustices and discrimination exist, and we further our mission by embracing the rich perspectives and experiences that arise from racial, ethnic, socioeconomic, sexual, gender, and religious diversity within our community.

PI_NAMEs: LEE, KELVIN P. (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: anti-cancer research;Antineoplastic Agents;Artificial Intelligence;Awareness;Basic Science;Biological;Biology;Biometry;Black Populations;Black race;Cancer Biology;Cancer Burden;Cancer Center;cancer research center director;cancer risk;Catchment Area;Characteristics;Clinical Cancer Center;clinical care;Clinical Pathways;Clinical Sciences;Code;Colorectal Cancer;Communities;community engaged research;community engagement;Community Outreach;Comprehensive Cancer Center;County;Data;Death Rate;Dedications;Development;Discrimination;Disease;Doctor of Philosophy;drug development;drug discovery;early phase clinical trial;Education;Environment;equity, diversity, and inclusion;Ethics;Ethnic Origin;experience;Fostering;Foundations;Funding;Gender;Generations;Grant;Graph;Growth;Guidelines;Health;health equity;Health Professional;Healthcare Systems;Hispanic Populations;Human Papilloma Virus Vaccination;Immunotherapy;Incidence;Indiana;Informatics;innovation;Institution;interdisciplinary collaboration;investigator-initiated trial;Journals;Leadership;Lifting;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;Medicine;member;Mission;mortality;multidisciplinary;Names;National Comprehensive Cancer Network;NCI-Designated Cancer Center;next generation;Non-Hodgkin's Lymphoma;Not Hispanic or Latino;Nursing Faculty;Obesity;Oncology;Ovarian;Patient Care;Patient-Centered Care;Patients;Pediatric Oncology;peer;Peer Review;Policies;Population;population health;Population Sciences;Prevention;Productivity;programs;Prostate;Publications;Race;Recording of previous events;recruit;Religion;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Risk Factors;Rural;rural dwellers;Science;Services;Smoking;social;social determinants;Social Sciences;Societies;socioeconomics;Standardization;Teenagers;Therapeutic;Training;Translational Research;Translations;Universities;Uterine Cancer;Vision

PROJECT_TITLE: GAIPO: graph artificial intelligence for pediatric oncology

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE Over 2 million individuals in the United States live with opioid use disorder. Opioid use disorder is correlated with poor postoperative pain and an increased risk of opioid-related harms, but strategies to improve surgical care for individuals with opioid use disorder are lacking. In this prospective study, we will examine the perioperative experiences of patients with opioid use disorder in order to develop and test a clinical care pathway that integrates care coordination, overdose prevention, peer coaching, and best practices in postoperative pain management to generate the necessary evidence to optimize surgical recovery for patients with opioid use disorder.

PI_NAMEs: BICKET, MARK  (contact);WALJEE, JENNIFER FILIP

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Acute Pain;Acute pain management;Address;Adult;American;Analgesics;Blue Cross;Blue Shield;care coordination;Caring;Case Mixes;Centers for Disease Control and Prevention (U.S.);Clinical;clinical care;Communication;Data;design;Development;Elements;Emergency department visit;Engineering;Event;evidence base;experience;Funding;Geography;Goals;Guidelines;Health;health care service utilization;Healthcare;high risk;hospital readmission;Hospitals;implementation outcomes;improved;Individual;Infrastructure;Intervention;Interview;Knowledge;Length of Stay;Lived experience;Medicine;Michigan;Modeling;Naloxone;Operative Surgical Procedures;opiate tolerance;Opioid;opioid exposure;opioid use;opioid use disorder;Outcome;Outpatients;Overdose;overdose prevention;Overdose reduction;overdose risk;Pain;Pain management;pain reduction;Pathway interactions;Patient Care;Patient Outcomes Assessments;patient safety;Patient-Centered Care;Patient-Focused Outcomes;Patients;peer coaching;peer recovery;peer support;Perioperative;Perioperative Care;Persons;Pilot Projects;Postoperative Pain;Postoperative Period;prescription opioid;Prevalence;prevent;primary outcome;programs;prospective;Prospective Studies;Provider;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recovery;Relapse;Reporting;Risk;Sampling;satisfaction;social;social health determinants;Structure;Surgical Management;Testing;Trauma;United States;United States National Academy of Sciences;uptake;Variant;Work

PROJECT_TITLE: Improving Perioperative Care for Patients with Opioid Use Disorder

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Prostate Cancer;Urologic Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative Metastasis is the major cause of cancer mortality, and effective therapies are urgently needed. Histone methyltransferase ASH1L is genetically amplified and overexpressed in metastatic cancers. The proposed project is expected to identify ASH1L as a key epigenetic determinant in priming immunosuppressive metastatic niche and develop effective targeted therapy and combinatorial immunotherapy for metastatic cancers.

PI_NAMEs: ZHAO, DI  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: advanced prostate cancer;ASH1L gene;Biological Markers;Biological Process;cancer cell;Cancer Etiology;cancer infiltrating T cells;Cells;checkpoint therapy;Cleavage Under Targets and Release Using Nuclease;clinically relevant;Combination immunotherapy;cytokine;Disease;Disease Progression;Disseminated Malignant Neoplasm;effective therapy;Epigenetic Process;epigenetic profiling;gene network;Genetic Transcription;Genetically Engineered Mouse;Goals;histone methylation;histone methyltransferase;Histone-Lysine N-Methyltransferase;Histones;Human;Immune;immune checkpoint;Immunosuppression;Immunotherapy;Inflammatory;Invaded;Knowledge;leukemogenesis;Malignant Neoplasms;Mediating;Meta-Analysis;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Methylation;Methyltransferase;Moderate Activity;Molecular;mortality;mouse model;Myeloid-derived suppressor cells;Neoplasm Metastasis;novel;Outcome;overexpression;Patients;PD-1 blockade;PD-1/PD-L1;PD-L1 blockade;pharmacologic;Pre-Clinical Model;programmed cell death ligand 1;programmed cell death protein 1;programs;Prostate;Proteomics;Resistance;Role;Shapes;Solid Neoplasm;T cell infiltration;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic Effect;therapeutic target;therapeutically effective;Transcriptional Activation;transcriptome;transcriptomic profiling;transcriptomics;tumor progression;tumor-immune system interactions;Visualization

PROJECT_TITLE: Determine the Role of Histone Methyltransferase ASH1L in Metastatic Prostate Cancer

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: COLLEGE PARK

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Narrative Ubiquitin-mediated signaling is involved in the regulation of a wide variety of biological processes including cell development and division, the immune response, and signal transduction. The ubiquitin-proteasome proteolytic pathway, the principal mechanism for turnover of short-lived proteins, has been the target for extensive drug design efforts, as defects in this pathway are associated with numerous diseases, including cancers, neurodegenerative disorders, developmental disorders, immune and inflammatory disorders, and muscle wasting. This research will enhance our understanding of the molecular mechanisms underlying recognition and regulation in ubiquitin-mediated signaling pathways and will guide the design of a novel class of inhibitors targeting ubiquitin-dependent protein degradation and other vital cellular pathways.

PI_NAMEs: FUSHMAN, DAVID  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: 26S proteasome;Address;Affinity;Amaze;analytical method;antigen processing;Binding;Binding Proteins;Biological Process;biophysical techniques;Cell Cycle;Cell Physiology;Cells;Chemicals;Complex;Computing Methodologies;Cyclic Peptides;Data;Dedications;Defect;Degradation Pathway;design;Development;developmental disease;Disease;DNA receptor;DNA Repair;Drug Design;Event;flexibility;Head;Immune;Immune response;Immunity;improved;Inflammation;Inflammatory;inhibitor;insight;interest;Knowledge;Length;Link;Lysine;Malignant - descriptor;Malignant Neoplasms;Measurement;Mediating;Methods;Modeling;Modernization;Molecular;Molecular Conformation;molecular marker;monomer;multicatalytic endopeptidase complex;multiple data types;Muscular Atrophy;Neurodegenerative Disorders;Neutrons;novel;Outcome;Pathway interactions;Peptides;Physiologic pulse;Physiological;Polyubiquitin;Polyubiquitination;preference;Property;protein degradation;protein transport;Proteins;receptor;Regulation;Research;Research Personnel;response;Roentgen Rays;Signal Pathway;Signal Transduction;Signaling Molecule;Specificity;structural determinants;Structure;Structure-Activity Relationship;System;Tail;Testing;Therapeutic;therapeutic development;three dimensional structure;Transcriptional Activation;Ubiquitin;Work

PROJECT_TITLE: Solution structure and dynamics of polyubiquitin chains

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Narrative The goal of this proposal is to provide fundamental knowledge about how the structure of the mammalian cone photoreceptor synapse determines its function in vision. Although this study deals only with healthy cones, it has implications for understanding how vision can be degraded by diseases of the outer retina such as retinitis pigmentosa and macular degeneration and how cone synapses can be restored following photoreceptor transplantationn.

PI_NAMEs: DEVRIES, STEVEN H (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: 3-Dimensional;absorption;Accounting;Address;AMPA Receptors;Apical;base;cell type;Cells;Cellular Morphology;Communication;Complex;Cone;cyclothiazide;Darkness;Dendrites;desensitization;design;Diameter;Disease;experimental study;ganglion cell;Glutamates;Goals;Homologous Gene;horizontal cell;Individual;Kainic Acid Receptors;Knowledge;Label;Light;light intensity;link protein;Macular degeneration;Measures;Mediating;Membrane;meter;Minor;Molecular;Molecular Structure;Mus;Natural regeneration;Neurons;novel;Output;parallel processing;Pattern;Photons;Photoreceptors;Play;postsynaptic;presynaptic;Presynaptic Terminals;Process;Property;Proteins;receptor;Recovery;response;Retina;Retinal Cone;Retinitis Pigmentosa;ribbon synapse;Rod;Role;sight restoration;Signal Pathway;Signal Transduction;Site;Slice;Spermophilus;statistics;Stereotyping;Stimulus;Stream;Structure;superresolution microscopy;Surface;Synapses;Synaptic Cleft;synaptic function;Synaptic Receptors;tau Proteins;Techniques;Testing;Thinness;Time;transmission process;Transplantation;Variant;Vesicle;Vision;Visual;Visual Aid;Visual Perception;visual processing;visual stimulus;Visual System;Visualization;voltage;Work

PROJECT_TITLE: Function of basal synapses at mammalian photoreceptors

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric;Physical Activity;Prevention;Sleep Research

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Children spend more time than ever using screens — increasingly on portable digital media devices like tablets and smartphones, but our understanding about how these devices impact health is lagging. This project proposes to uncover how patterns of digital media use are formed and maintained and examine how those patterns predict mental health and cardiovascular health risk over time. The novel forms of media measurement used in this project – including passive mobile sampling, ecological momentary assessment and accelerometry – will allow us to uncover the unique and complex ways in which digital media impacts health behaviors.

PI_NAMEs: ARMSTRONG, BRIDGET R. (contact)

PROGRAM_OFFICER_NAME: GALLEN, COURTNEY LEIGH

PROJECT_TERMS: Accelerometer;adaptive intervention;Adoption;Age;Beds;Behavior;cardiovascular health;Cellular Phone;Child;cohort;Complex;Data;Data Collection;design;Devices;digital measure;digital media;digital phenotyping;Disease;distraction;Ecological momentary assessment;Emotional;emotional functioning;Etiology;Failure;Family;Future;Guidelines;Habits;Health;Health behavior;Heterogeneity;Hour;innovation;Internet;Intervention;Link;Measurement;Measures;media use;Mental Health;Methods;mobile sensing;Moods;negative affect;non-compliance;novel;Obesity;observational cohort study;Outcome;Parents;Pattern;personalized intervention;Persons;Physical activity;poor sleep;portability;Problem behavior;Protocols documentation;rapid growth;Recommendation;Research;Restaurants;Risk;Role;Sampling;sedentary lifestyle;Sleep;Sleep Disorders;social;Symptoms;System;Tablets;Technology;Time;tv watching;Update;Work

PROJECT_TITLE: Causes and Consequences of Preschooler's Digital Media Use: The Role of Sleep, Physical Activity, Sedentary Behavior and Social Emotional Health

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: Project Narrative The proposed work will further develop and continue to maintain the UltraScan software suite, which contributes to the analysis of biophysical solution data with unmatched resolution and efficiency. Among the proposed developments are codes to provide comprehensive and automated reporting to support GMP operation of analytical ultracentrifugation experiments performed with the Beckman-Coulter Optima AUCTM instrument, to offer electronic signatures and audit trails for GMP operation, and automated tools for structure determination. These efforts are highly relevant for many current NIH and NSF investigations, support the development of therapeutics against any disease studied on the molecular level, contribute important tools for studies into the mechanisms of aging, cancer, HIV, and neurodegenerative diseases, improve patient safety through rigorous characterization of drugs, and inform investigations into their interactions with drug targets.

PI_NAMEs: BROOKES, EMRE H. (contact);DEMELER, BORRIES ;SAVELYEV, OLEKSIY

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;Adoption;aging mechanism;Algorithms;analytical ultracentrifugation;Anisotropy;APBA1 gene;Architecture;archive data;automated analysis;Automation;base;beamline;Biochemistry;Biomedical Research;biophysical analysis;Biophysics;Biopolymers;Cellular biology;Centenarian;Code;code development;Collaborations;Communities;Complex;Computer software;Data;data acquisition;Data Analyses;data archive;Data Protection;Data Security;data sharing;density;design;Development;Disease;Drug Targeting;Electronics;Ensure;experimental study;flexibility;Funding;Future;High Performance Computing;high throughput analysis;HIV;Hour;improved;Infrastructure;instrument;Intuition;Investigation;Kinetics;Laboratories;Libraries;Licensing;Linux;macromolecular assembly;Maintenance;Malignant Neoplasms;Management Information Systems;materials science;Methods;middleware;models and simulation;Modernization;Molecular;Molecular Conformation;Molecular Structure;nanoscience;Network-based;Neurodegenerative Disorders;Neutrons;next generation;novel;open source;Operating System;operation;Ownership;patient safety;Pharmaceutical Preparations;Property;protocol development;Publications;Ramp;Reaction;Reporting;Reproducibility;Research;Resolution;Resources;Roentgen Rays;Science;Services;simulation;structural biology;Structure;supercomputer;Supercomputing;Support System;System;Techniques;Therapeutic;therapeutic development;tool;Training;United States National Institutes of Health;Update;user protection;Work;X-Ray Crystallography

PROJECT_TITLE: Continued Development and Maintenance of the UltraScan Software

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: NARRATIVE In this project, we will discover new genetic factors that elucidate potential mechanisms for the effects of APOE ɛ2 and ɛ4 on AD risk in multiple ethnic populations, use this information to understand how genetic variation leads to pathologic states, identify novel biomarkers, and provide models which can be used in small molecule drug screens for potential AD treatments

PI_NAMEs: FARRER, LINDSAY A. (contact);JUN, GYUNGAH ;WOLOZIN, BENJAMIN L

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: 3-Dimensional;Address;African American population;African ancestry;Age;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;Astrocytes;Biology;Blood;Blood specimen;Boston;Brain;brain cell;brain tissue;Cardiovascular Diseases;Catalytic Domain;cell type;Cells;Centenarian;cognitive performance;Complement 4b;Complement component C4a;Complementary DNA;Data;Data Set;differential expression;Disease;Disparity;Dose;Drug Screening;Ethnic Origin;Ethnic Population;European;European ancestry;Exhibits;exome sequencing;Experimental Genetics;Framingham Heart Study;Functional disorder;gene complementation;Gene Targeting;Genes;Genetic;Genetic Diseases;genetic risk factor;genetic variant;Genetic Variation;genome sequencing;genome wide association study;genome-wide;Genotype;Gliosis;Heterozygote;Homozygote;Human;human induced pluripotent stem cells;Immunofluorescence Immunologic;Impaired cognition;Induced Neurons;induced pluripotent stem cell;Ischemic Stroke;Longevity;Measures;Mediating;Methylation;MGMT gene;Microglia;Modeling;multi-ethnic;Myocardial Ischemia;Nerve Degeneration;neuroinflammation;Neurons;neuropathology;novel;novel marker;Participant;Pathologic;Pathology;Phosphoric Monoester Hydrolases;Plasma;polygenic risk score;Population;Population Group;Population Heterogeneity;preservation;Process;protective effect;Protein Dephosphorylation;Protein phosphatase;Proteins;Proteome;Proteomics;Research;Resources;risk variant;Sampling;sex;Site;small hairpin RNA;small molecule;spheroids;Study Subject;Subgroup;tau Proteins;Testing;three dimensional cell culture;Tissues;trait;transcriptome;Universities;Variant;whole genome;Woman;Work

PROJECT_TITLE: APOE Genotype Mediated Effects on Alzheimer Disease Risk and Mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-J (J2)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative: This study will address critical gaps in knowledge, including the mechanisms of inhibitory synapse formation and the role of astrocytes in inhibitory synapse development in the hippocampus. Since impaired inhibition and deficits in inhibitory interneurons are thought to underlie the development of hyperactive neuronal networks in neurodevelopmental disorders such as autism spectrum disorder, schizophrenia, and epilepsy, the proposed work may lead to the development of novel therapeutic targets to treat neurodevelopmental disorders. Proposed studies will utilize unique mouse models, state-of-art optophysiological analysis and imaging approaches, biochemical studies and translationally relevant video-EEG monitoring for seizures which we have used to evaluate epileptogenicity during developmental dysregulation of interneuronal circuits.

PI_NAMEs: ETHELL, IRYNA M (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Ablation;Adhesives;Affect;Astrocytes;autism spectrum disorder;axon guidance;behavior test;Biochemical;Biochemistry;Brain;Brain Diseases;cell motility;Cells;Child;Cholecystokinin;critical developmental period;Cues;D Cells;Data;Databases;de novo mutation;Development;Developmental Process;Disease;Electroencephalography;Electrophysiology (science);EPHB2 gene;EphB2 Receptor;Ephrin B Receptor;Ephrin Receptor EphB1;Ephrin-B1;Ephrin-B2;Ephrins;Epilepsy;Equilibrium;ErbB4 gene;Excision;Excitatory Synapse;Functional disorder;gain of function;Genes;Genetic study;Goals;hippocampal pyramidal neuron;Hippocampus;Human;Hyperactivity;imaging approach;Immunohistochemistry;Impairment;In Vitro;in vivo;inhibitory neuron;Inhibitory Synapse;Interneurons;Intervention;Knock-in Mouse;Knock-out;Knowledge;Ligands;Link;loss of function;Maintenance;Mediating;Microscopy;Molecular;Monitor;mouse model;Mus;nerve supply;Neurodevelopmental Disorder;neuronal cell body;Neuronal Dysfunction;Neurons;new therapeutic target;novel;optogenetics;overexpression;Parvalbumins;Phosphotransferases;Predisposition;prevent;Publishing;Pyramidal Cells;receptor;Receptor Inhibition;Receptor Signaling;Research;response;Role;Schizophrenia;Seizures;Signal Transduction;Somatostatin;Synapses;synaptogenesis;Testing;United States;Viral;Visual Cortex;Whole-Cell Recordings;Work

PROJECT_TITLE: Molecular and cellular mechanisms of inhibitory synapse development

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Most people with schizophrenia suffer from significant disability for most of their adult lives. Impaired cognition has been shown to play an important role in determining the extent of disability that patients experience but is not currently treatable. This research program is designed to increase understanding of the specific cognitive and neural mechanisms that are dysfunctional in schizophrenia to provide more specific targets for treatment development research.

PI_NAMEs: GOLD, JAMES M. (contact);LUCK, STEVEN J

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Address;Adult;Affect;Attention;Behavior;Behavioral;Cognitive;cognitive ability;Cognitive deficits;cognitive function;cognitive neuroscience;cognitive task;cognitive training;Computer Models;Delusions;design;Development;disability;Disease;Drowsiness;Economic Burden;Elements;Empirical Research;Executive Dysfunction;executive function;Exhibits;experience;Functional disorder;Goals;Hallucinations;Impaired cognition;Impairment;improved;Link;Location;Maintenance;Measures;Mental disorders;Mental Health;Modeling;Motivation;Nature;neural;Neural Network Simulation;neuroadaptation;Neurobiology;Neurocognitive;neuromechanism;Neurons;Outcome;Pathology;Patients;Pattern;Performance;Persons;Pharmaceutical Preparations;Pharmacological Treatment;Play;Population;Process;programs;Psychopathology;Research;research and development;Resources;Role;Sampling;Schizophrenia;Short-Term Memory;Source;Statistical Methods;Structure;Symptoms;Synapses;Synaptic plasticity;System;Testing;therapy development;Weight

PROJECT_TITLE: Cognitive Neuroscience of Attention and Working Memory in Schizophrenia

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Cervical Cancer;Clinical Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

PHR: Public Health Relevance Cervical cancer burden represents a major global health disparity, and high coverage of HPV vaccine will be necessary to substantially reduce incidence and ultimately achieve cervical cancer elimination in high-burden settings like Eastern Africa. Although many countries in the region have national programs to offer HPV vaccine for free to preadolescent girls, uptake is low, and little is known about who is getting vaccinated (and who is not). Through mixed methods research to collect and analyze data on the multi-level factors associated with HPV vaccination in Africa, this proposed study seeks to identify where future interventions may be best-targeted to address the specific barriers that are limiting HPV vaccine coverage in Africa.

PI_NAMEs: MOUCHERAUD, CORRINA  (contact)

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: Address;Affect;Africa;African;Age;Area;Behavior;Behavioral;Cancer Burden;Case Study;Cessation of life;Communities;Country;Data;Data Collection;Daughter;design;Development;Dose;Eastern Africa;Eligibility Determination;Environment;Evaluation;experience;falls;Female Adolescents;Future;girls;global health;Goals;Health;Health care facility;health disparity;Health system;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Immunization Programs;improved;Incidence;Individual;informant;innovation;insight;Intention;Intervention;Interview;Kenya;Link;Location;Logistic Regressions;low and middle-income countries;Malawi;Malignant neoplasm of cervix uteri;Methods;Modeling;models and simulation;Morbidity - disease rate;mortality;Motivation;multidisciplinary;multilevel analysis;Outcome;Parents;Policies;Policy Maker;Population;Population Heterogeneity;Poverty;preadolescence;prevent;programs;public health relevance;Random Allocation;Reporting;Research;Research Methodology;residence;Resource-limited setting;Respondent;Sampling;Schools;Science;social;social norm;Standardization;Surveys;System;Telephone;Translating;Trust;unvaccinated;uptake;Vaccinated;Vaccination;vaccine acceptance;vaccine access;vaccine delivery;Vaccines;Woman;Work;World Health Organization

PROJECT_TITLE: Identifying modifiable multi-level factors associated with HPV vaccine uptake in Kenya and Malawi

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Genome-Wide Association Studies (GWAS) have identified thousands of common, non-coding variants associated with disease. While integration of GWAS data with gene expression from bulk tissues has uncovered some of the underlying genes and mechanisms, only a fraction of trait heritability can be explained by existing bulk datasets and the majority of GWAS loci do not colocalize with QTLs from bulk expression data. Understanding which cell types and contexts are the most relevant for a given disease – both at the level of individual loci and across the genome – is thus critical to moving from individual variants to an understanding of broader processes and, eventually, to effective interventions.

PI_NAMEs: GUSEV, ALEXANDER  (contact);PRICE, ALKES L;RAYCHAUDHURI, SOUMYA

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Alleles;Benchmarking;Biological;Biology;causal variant;cell type;Cells;Cellular biology;Chromatin;Collaborations;Collection;Communities;Complex;Computer software;Data;data integration;Data Set;Disease;disease-causing mutation;effective intervention;Epigenetic Process;epigenome;epigenomics;Gene Expression;Genes;genetic architecture;Genetic Transcription;Genome;genome wide association study;Heritability;Immune;improved;Individual;Maps;Measurement;Modality;Modeling;Molecular;Multiomic Data;multiple omics;Nature;neuropsychiatry;novel;novel strategies;Phenotype;Population;Principal Component Analysis;Process;Publications;Publishing;Quantitative Trait Loci;Regulatory Element;Research;Resolution;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Statistical Models;Study models;Tissues;tool;trait;Transcription Process;transcriptomics;Untranslated RNA;Variant;Work

PROJECT_TITLE: Integrative modelling of single-cell data to elucidate the genetic architecture of complex disease

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Over half of adolescents with Down syndrome experience difficulty being understood by others which can lead to social isolation and loneliness which, in turn, leads to poor mental and physical health outcomes. Interventions to improve speech production in adolescents with Down syndrome are rare and yield mixed results because of the lack of empirical information regarding the elements that contribute to successful communication outcomes during daily life activities. By applying a precision medicine approach within a biopsychosocial framework, this proposal will lay the foundation for the creation of interventions that center the patient perspective, address the underlying impairment based on comprehensive speech production profiles, and engage societal structures that contribute to disability.

PI_NAMEs: WHITE, MEGHAN DARLING (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TITLE: A biopsychosocial approach to the deep phenotyping of communicative participation in adolescents with Down syndrome

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Neurosciences;Nutrition;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BLOOMINGTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

PHR: PROJECT NARRATIVE Athletes engaged in contact sports can experience hundreds of mild “subconcussive” head hits annually from soccer heading and American football tackles, which may lead to an increased risk for the development of brain disorder in later life. However, there are no protective interventions for subtle brain damage from repetitive mild head hits. We will test whether daily supplementation of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) –two of primary fish oil components– can minimize such brain injury induced by repetitive soccer heading.

PI_NAMEs: KAWATA, KEISUKE  (contact);MICKLEBOROUGH, TIMOTHY DEREK;NEWMAN, SHARLENE D

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acids;Acute;Address;Adult;Age;aged;American;animal data;Anisotropy;Astrocytes;Athletic;Attenuated;Axon;axon injury;Biological Markers;Blood;Boxing;Brain;Brain Diseases;Brain Injuries;Calcium;Cardiovascular system;Cell Physiology;Characteristics;Chronic;Clinical;Clinical Research;Clinical Trials;cognitive function;concussive symptom;contact sports;Controlled Clinical Trials;Corpus Callosum;Data;Development;dietary supplements;Docosahexaenoic acid supplementation;Docosahexaenoic Acids;Double-Blind Method;Eicosapentaenoic Acid;endoplasmic reticulum stress;excitotoxicity;Exhibits;experience;Fish Oils;Functional Magnetic Resonance Imaging;Glial Fibrillary Acidic Protein;Growth Factor;Head;head impact;Human;Hypertension;hypertensive;Image;Impairment;insight;Intervention;late life;Lead;Life;Light;Manufactured football;Measures;Mediating;Mental Health;Monitor;multimodality;nerve injury;Nervous System Disorder;Nervous System Trauma;neural;neural growth;Neurobiology;Neurodegenerative Disorders;neurofilament;Neurologic;Neurons;neuroprotection;Omega-3 Fatty Acids;Outcome;oxidation;Persons;Physiological;placebo group;Placebos;Plasma;Play;Policies;preclinical study;pressure;prevent;promote resilience;prophylactic;randomized placebo controlled trial;Randomized, Controlled Trials;Reporting;resilience;response;Rest;Risk;Rugbies;Saccades;Seasons;Serum;Severities;sex;Soccer;Sports;Stress;Structure;subconcussion;Subgroup;tau Proteins;Testing;Time;Translating;Traumatic Brain Injury;treatment effect;UCHL1 gene

PROJECT_TITLE: A mechanistic clinical trial of omega-3 fatty acids to prevent subconcussive neural injury

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: SOCIAL SCIENCES

PHR: PROJECT NARRATIVE Evidence indicates that race/ethnicity-, sexual orientation, and gender-related discrimination is linked to increased harmful cardiometabolic health behaviors (CHB; e.g., sleep, physical activity, and tobacco and alcohol use). However, there is limited research demonstrating the influence of online discrimination, a critical social determinant of health, on CHB among diverse groups of SGM. Our novel multi-method study design will illuminate how discrimination operates in online environments and physical spaces, as well as highlight key protective factors, which can be used to better distill risk and inform targeted mediums for harmful CHB prevention interventions among SGM.

PI_NAMEs: CHUNARA, RUMI ;COOK, STEPHANIE HAZEL (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Accelerometer;Address;Age;Alcohol consumption;American Heart Association;Behavior Therapy;Black race;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cellular Phone;Censuses;Characteristics;Climate;Collaborations;Color;community engagement;Coping Behavior;culturally appropriate intervention;Data;diaries;Discrimination;Environment;Ethnic Origin;experience;Exposure to;Facebook;Future;Gender;gender minority group;Hate;Health;Health behavior;health disparity;Health Sciences;Homophobia;Individual;innovation;Internet;Intervention;Language;Latino;Lead;Link;Machine Learning;Measurement;Measures;Mental Health;Methods;minority engagement;Minority Groups;Moods;Neighborhoods;novel;online community;Outcome;Participant;Pathway interactions;Patient Self-Report;peer;perceived discrimination;Persons;Physical activity;physical inactivity;Policies;poor sleep;preventive intervention;primary outcome;privacy preservation;protective factors;Public Health;Questionnaires;Race;racial discrimination;racial identity;Research;Research Design;Resources;Risk;Role;Sampling;secondary outcome;Self Assessment;Sex Discrimination;Sex Orientation;Sexual and Gender Minorities;sexual identity;sexual minority group;sexual minority men;Sleep;smartphone application;social cohesion;social determinants;social health determinants;social media;Social Protection;Social support;Speech;Stress;stressor;Support Groups;Time;Tobacco use;Twitter;vulnerable community;Work;young adult

PROJECT_TITLE: Social Media Discrimination, Cardiometabolic Health Behaviors, and Social Protections among Sexual and Gender Minorities

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Cancer;Immunotherapy

PHR: Project Narrative: This proposal is founded on the critical finding that extracellular matrix (ECM) proteins in peripheral tissues play an active role in modulating Natural Killer (NK) cell effector functions. The central aim of the proposed work is to elucidate the precise mechanisms governing this ECM-mediated regulation of NK cell response in solid cancers. The findings from this work will reveal novel NK cell regulatory mechanisms that can be harnessed to boost NK cell immunity against solid cancers.

PI_NAMEs: DEMEHRI, SHADMEHR  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: adaptive immunity;ADGR1 gene;anti-tumor immune response;Antibodies;antibody-dependent cell cytotoxicity;Biological Assay;Blocking Antibodies;Breast;Breast Melanoma;Cancer Etiology;Cell Communication;cell killing;Cell Physiology;Cells;chemokine;chemotherapy;Circulation;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Collagen;Collagen Receptors;CRISPR/Cas technology;Cues;cytokine;cytotoxicity;Data;Dendritic cell activation;Deposition;Development;ECM receptor;Effector Cell;Elastin;elastin-binding protein;Engineering;Exposure to;Extracellular Matrix;Extracellular Matrix Proteins;Fibronectins;Flow Cytometry;gene-editing approach;Goals;healthcare burden;Healthcare Systems;Helper-Inducer T-Lymphocyte;Hematologic Neoplasms;Homeostasis;Human;Immune response;Immune System Diseases;Immunity;Immunologic Surveillance;Immunotherapeutic agent;improved;In Vitro;Infiltration;Integrins;Killer Cells;Knock-out;Laboratories;Laminin;Ligands;Ligation;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Modeling;Morbidity - disease rate;mortality;mouse model;Natural Killer Cells;NK Cell Activation;NK cell therapy;novel;novel therapeutic intervention;Outcome;Outcomes Research;Peripheral;Phenotype;Play;Production;programs;receptor;recruit;Regulation;Research;Resistance;response;Role;scaffold;side effect;Skin;Skin Cancer;Solid;success;System;T-Lymphocyte;Testing;Tissues;transcriptome sequencing;tumor;tumor microenvironment;United States;Virus Diseases;Work;Xenograft Model

PROJECT_TITLE: Interplay of natural killer cells and extracellular matrix proteins in solid cancers


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative – This highly translational proposal (a) has as a main goal the validation of glycated CD59 (GCD59, the glucose inactivated form of the key complement regulatory protein known as CD59) in human urine, as a novel diabetes biomarker (b) addresses major Public Health priorities, and (c) is based on a robust hypothesis, extensive preliminary data and availability of all assays/reagents needed. The relevance of the proposed studies is highlighted by the following facts 1) diabetes mellitus affects ≈25 million Americans, and diabetic complications are a major cause of morbidity and mortality in the U.S., 2) treatment of diabetic complications costs a staggering 245 billion dollars/year, and is expected to rise to >300 billion by 2034, and 3) pregnancy-induce glucose intolerance is a major cause of maternal-fetal adverse pregnancy outcomes to the point that current standard of care is to screen for this condition all pregnant women who do not have prior diabetes.

PI_NAMEs: HALPERIN, JOSE A (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, JEAN M

PROJECT_TERMS: Address;adverse outcome;adverse pregnancy outcome;Affect;Agreement;American;American College of Obstetricians and Gynecologists;Belgium;Biological Assay;Biological Markers;Blood;Boston;Cardiovascular Diseases;Caring;Classification;Clinical;clinical biomarkers;cohort;Complement;complement system;Complications of Diabetes Mellitus;Consumption;cost;cost effective;Country;Data;Detection;Development;Devices;Diabetes Mellitus;Diagnosis;Diagnostic tests;diagnostic tool;Early Diagnosis;Early treatment;Enzyme-Linked Immunosorbent Assay;Epidemic;Equipment;Europe;fetal;Fetus;Frequencies;Fructosamine;Future;General Population;genetic regulatory protein;Gestational Diabetes;Glucose;Glucose Intolerance;glycation;Glycosylated hemoglobin A;Goals;health care availability;Health care facility;Healthcare;high risk;High Risk Woman;home test;hospital care;Human;Hyperglycemia;Incidence;Individual;Infant;Ireland;Laboratories;Link;maternal hyperglycemia;Measurement;Measures;Medical;Methods;Mobility decline;Monitor;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mothers;Newborn Infant;Non-Insulin-Dependent Diabetes Mellitus;novel;novel diagnostics;Obesity;Odds Ratio;OGTT;Oral;Outcome;Pathogenesis;Performance;perinatal complications;perinatal outcomes;Plasma;point of care;Population Heterogeneity;Postpartum Period;Prediabetes syndrome;Pregnancy;Pregnancy Outcome;Pregnant Women;Prenatal care;Prevalence;prospective;public health priorities;Publications;Publishing;Reagent;Recommendation;Reproducibility;Research;Resources;response;Risk;Risk Factors;rural area;Sampling;screening;screening guidelines;Sensitivity and Specificity;standard of care;Testing;Time;tool;Underserved Population;United States;United States Preventative Services Task Force;Urine;Validation;Visit;Woman

PROJECT_TITLE: Urine levels of Glycated CD59 for screening and diagnosis of pregnancy-induced glucose intolerance

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Nanotechnology;Neurosciences;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Though we are unsure how to interpret their function, mutations in genes that read and write DNA methylation marks are associated with neurodevelopmental disease and intellectual disabilty. Our studies will develop new sequencing approaches to understand the mechanisms behind DNA methylation changes in the brain and assess how loss of a key methylation reader, MeCP2, affects neuronal function. In the future, our approaches can be applied by investigators to understand the function of DNA methylation and suggest new therapies to treat neurodevelopmental disorders and intellectual disability.

PI_NAMEs: EDWARDS, JOHN R. (contact);GABEL, HARRISON W

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Address;Affect;Alleles;autism spectrum disorder;autism symptoms;barrier to testing;Binding;Binding Proteins;Biological Assay;bisulfite;Brain;Cell Shape;cell type;Cells;Cerebellum;Chemicals;Chemistry;Clinical;CpG dinucleotide;Cues;Cytoplasmic Granules;Cytosine;Data;demethylation;Detection;Development;Discrimination;Disease;DNA;DNA Methylation;DNA Methylation Regulation;DNA Sequence;Early Onset Alzheimer Disease;Enhancers;Enzymes;Epigenetic Process;Frontotemporal Dementia;Future;Gene Activation;Gene Expression Regulation;gene function;gene repression;Genes;Genetic;genetic regulatory protein;Genetic Transcription;genome-wide;Genomics;improved;In Vitro;Individual;insight;Intellectual functioning disability;Intrinsic factor;Length;Maintenance;Mammals;Mediating;Methods;Methyl-CpG-Binding Protein 2;Methylation;methylation pattern;methylome;Modification;Molecular;Mus;Mutate;Mutation;nanopore;Nervous System;Nervous System Disorder;neurodevelopment;Neurodevelopmental Disorder;neuron development;neuronal circuitry;Neuronal Differentiation;Neurons;neuroprotection;novel strategies;novel therapeutics;Oligonucleotides;oxidation;Pathology;Pathway interactions;Pattern;Play;postnatal development;postnatal period;Process;programs;promoter;Property;Proteins;Reader;Regulation;Regulatory Pathway;Repression;Research;Research Personnel;Resolution;response;Rett Syndrome;Role;Sampling;Signal Transduction;Specific qualifier value;Testing;Transcriptional Regulation;transcriptome;Variant;Writing

PROJECT_TITLE: New approaches to determine the function of neuronal epigenetic marks

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

PHR: The protein α-Synuclein (αS) and lipid membranes are key components of Lewy bodies (LBs), the hallmarks of Parkinson's disease (PD), Lewy body dementia (LBD) and other synucleinopathies. αS interacts with lipids and fatty acids and alters homeostasis, but despite the brain being highly lipid-rich, the role of lipid metabolism in PD and LBD remains largely unresolved. The PI will lead a diverse team with expertise in lipidomics, αS biochemistry and PD genetics in vivo and in vitro to validate LIPE (hormone sensitive lipase) as a candidate therapeutic target in vivo and establish the mechanism of rescue focused on αS:lipid membrane interactions at the synapse.

PI_NAMEs: FANNING, SARANNA  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: 3' Untranslated Regions;Address;alpha synuclein;Behavior;Binding;Biochemical;Biochemistry;Biological Assay;Biology;Brain;Brain region;Caenorhabditis elegans;Cell Physiology;Clinical Trials;Corpus striatum structure;Data;Defect;Degradation Pathway;dementia risk;density;Detergents;Development;Disease;disease phenotype;Dissection;Drug Targeting;Enhancers;Enzymes;Equilibrium;experimental study;fatty acid metabolism;Fatty Acids;Fiber;Functional disorder;Genes;Genetic;genetic analysis;Genetic Diseases;genome wide association study;Goals;Homeostasis;Human;In Vitro;in vivo;in vivo Model;infancy;inhibitor;innovation;insight;Investigation;Lead;Lewy Bodies;Lewy Body Dementia;Lewy neurites;Link;Lipase;lipid metabolism;lipidomics;Lipids;Medical;Membrane;Membrane Fluidity;Membrane Lipids;Midbrain structure;Modeling;Monounsaturated Fatty Acids;Morphology;motor deficit;mouse model;Mus;National Institute of Neurological Disorders and Stroke;Neurons;neuropathology;neuroprotection;Neurotransmitters;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Phospholipids;Physiological;Point Mutation;Post-Translational Protein Processing;Process;promoter;Property;Proteins;Publications;Publishing;Regulation;Reporting;Research;Resistance;response;Role;sporadic Parkinson's Disease;Stearoyl-CoA Desaturase;sterol esterase;Synapses;Synaptic Vesicles;Synaptosomes;synucleinopathy;System;Therapeutic;therapeutic candidate;therapeutic development;therapeutic target;unilamellar vesicle;Unsaturated Fats;Urea;Vesicle

PROJECT_TITLE: Mechanistic Dissection of Lipase (LIPE) Regulation of Fatty Acid Homeostasis as a Parkinson's Disease and Lewy Body Dementia Therapeutic Strategy

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Genetics;Human Genome;Osteoporosis

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative: Osteoporosis is a major public health burden and a condition characterized by decreased bone strength. Current estimates indicate that 12 million people suffer from osteoporosis in the U.S. Osteoporosis is largely influenced by genetics. This project seeks to identify the genes influencing bone strength using an innovative mouse genetics approach. Successful completion of this project will identify new therapeutic targets for the treatment of osteoporosis.

PI_NAMEs: FARBER, CHARLES R (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Address;Affect;American;Biological;Biology;Biomechanics;bone;bone cell;Bone Density;Bone Diseases;bone mass;bone strength;Candidate Disease Gene;candidate identification;causal variant;Cell Line;Characteristics;Chromosome 1;Chromosome 10;Chromosome 6;clinically relevant;cohort;Data;density;Detection;Development;Disease;diverse data;Eye;Female;gene discovery;Genes;Genetic;genetic analysis;genetic approach;genome wide association study;genome-wide;genomic data;Homologous Gene;Human;In Vitro;in vivo;innovation;Knockout Mice;Maps;Measures;Minerals;Molecular;mouse genetics;mouse model;Mus;new therapeutic target;novel;Osteoblasts;Osteoclasts;Osteocytes;Osteoporosis;Persons;Phenotype;Population;Prevention;Property;Public Health;Quantitative Trait Loci;Regulation;Resources;Role;Sample Size;skeletal;sulfhydryl oxidase;Surface;Testing;Tissues;trait;transcriptomics;whole genome;Work

PROJECT_TITLE: Large-Scale Genetic Analysis of Bone Strength in Diversity Outbred Mice

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE Existing approaches to measuring intersectional discrimination (i.e., racial/ethnic-, sexual orientation, and/or gender-related) and related cardiometabolic health behaviors (CHB; i.e., physical inactivity, dysregulated sleep, and tobacco and alcohol use) lack the ability to capture the real-world context in which intersectional discrimination occurs, the momentary appraisal of such events, and resultant behaviors. To address this limitation, we will use a validated novel geographically-explicit momentary assessment (GEMA) method, which allows for the accurate capturing of the duration and frequency of exposure situated within the context in which these behaviors and exposures occur among young sexual and gender minorities (YSGM) as well as explores risk and protective factors for harmful CHB among diverse YSGM. This study will demonstrate the utility of the predictive models and variable creation for future CHB Just in Time interventions.

PI_NAMEs: COOK, STEPHANIE HAZEL (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: adaptive intervention;Address;Affect;Age;Alcohol consumption;Area;Behavior;Behavior Therapy;Buffers;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Censuses;cisgender;cohort;Communities;Complex;Cues;Data;design;Discrimination;disease disparity;Disparity;Ecological momentary assessment;effective intervention;emerging adult;Environment;Ethnic Origin;Ethnic Population;Event;experience;Exposure to;Feeling;Frequencies;Future;Gender;Gender Identity;gender minority group;Geographic Locations;Geography;Health;Health behavior;Heterosexuals;Home;improved;Individual;Inequality;innovation;Interpersonal Relations;Intervention;Interview;Life Cycle Stages;Link;Literature;Lived experience;Location;Maps;Measures;Methodology;Methods;minority children;novel;Participant;Pattern;perceived discrimination;Physical activity;physical inactivity;Planet Earth;Population;Positioning Attribute;predictive modeling;prevent;Prevention;Prevention Research;preventive intervention;protective factors;Protocols documentation;Race;racial population;Random Allocation;recruit;Reporting;Research;Resources;Risk;Risk Factors;Safety;Sampling;Schools;Sex Orientation;Sexual and Gender Minorities;sexual minority group;Sleep;Smoking;social;social cohesion;Social Protection;social relationships;Thinking;Time;Tobacco use;Travel;Work

PROJECT_TITLE: Geographically-Explicit Ecological Momentary Assessment Protocol to Assess the Linkages Between Intersectional Discrimination and CVD Risk Among Sexual and Gender Minorities

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Microbiome

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This pilot study investigates the impact of moisturizers on age-associated skin barrier decline and inflammation. Because moisturizers target a large potential source of chronic inflammation and are low risk, they could be an important tool in reducing the impact of inflammation on morbidity and aging.

PI_NAMEs: ABUABARA, KATRINA ELAINE (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Affect;Age;age related;age related decline;Age Years;Aging;Allergens;Animals;Area;Attention;Blinded;Brain natriuretic peptide;C-reactive protein;Ceramides;Cessation of life;China;Chronic;Clinical;commensal microbes;community setting;Consensus;cost effective;Cream;Data;data integrity;Defense Mechanisms;Dermis;design;Dryness;Effectiveness;efficacy trial;electric impedance;Environmental Exposure;Equilibrium;frailty;Future;Geroscience;Human;Hydration status;Immune;immunoregulation;improved;Individual;Inflammaging;Inflammation;Inflammatory;inflammatory marker;innovation;Interleukin-6;Interleukins;Intervention;Link;Lipids;Measures;microbial;microbial community;Morbidity - disease rate;mortality;multiple chronic conditions;Mus;normal aging;Ointments;old mice;older adult;Organ;Outcome;Participant;pathogen;pathogenic microbe;Penetrance;Permeability;Petrolatum;pharmacologic;Pilot Projects;pilot trial;Placebos;premature;Process;Protocols documentation;Public Health;Randomized;recruit;repaired;Research;Research Personnel;Resistance;response;restoration;retention rate;Risk;Role;Senility;Serum;Skin;skin barrier;skin microbiome;Source;Sterility;Surface;systemic inflammatory response;TNF gene;tool;Toxin;treatment duration;trial design;Water

PROJECT_TITLE: A pilot trial of skin barrier restoration to reduce systemic inflammation

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]