NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: ECLIPSE BIOINNOVATIONS INC

PHR: Narrative The traditional path to the successful development of new therapeutic compounds consists of a timeline spanning years to decades and budgets estimated into the billions of dollars; it typically begins with the screening of tens of thousands of small molecules, which are then narrowed down to a few tens of molecules before ever starting the clinical trial phases. Recently, regulatory agencies have been demanding a deeper understanding of the mechanism of action (MOA) before compounds are allowed to enter clinical trials. In this SBIR application, we are proposing to develop a secondary drug screening platform, called eMOA™, that will enable faster and more cost-effective drug development by leveraging both transcriptomics, translatomics, and a database of small molecules with known MOA to power a machine learning model to assign MOA to newly screened compounds.

PI_NAMEs: SHISHKIN, ALEXANDER A (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Adverse effects;Affect;analytical tool;Apoptosis;Autophagocytosis;Basic Science;Biological;Biological Assay;Biotechnology;Budgets;candidate identification;Cell Physiology;Cell Proliferation;Classification;Clinical Trials;clinically relevant;commercialization;Confidence Intervals;cost;cost effective;crosslink;Data;Data Set;Databases;design;Development;drug development;Drug Screening;drug-like compound;Early identification;Evaluation;FDA approved;FRAP1 gene;Gene Expression;high throughput screening;improved;Industry;inhibitor;innovation;insight;interest;Label;lens;Libraries;Machine Learning;machine learning model;Marketing;Measures;Messenger RNA;Molecular Mechanisms of Action;Monoclonal Antibodies;mTOR inhibition;multiple omics;Noise;novel therapeutics;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;pre-clinical;Process;Program Development;programs;Protein Biosynthesis;Proteins;Proteomics;Research;Ribosomal Proteins;Ribosomal RNA;ribosome profiling;Ribosomes;RNA;ROC Curve;Sampling;screening;Series;Services;Shotguns;Signal Pathway;Signal Transduction;Small Business Innovation Research Grant;small molecule;Techniques;Testing;Therapeutic;Therapeutic Agents;therapeutic candidate;timeline;Training;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Translational Regulation;Translational Repression;Translations;translatome

PROJECT_TITLE: eMOA: A Multi-Omic Service for Mechanism of Action Determination in Drug Screening

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-J (10)]


ADMINISTERING_IC: HG

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: CARY

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: DNALI DATA TECHNOLOGIES, INC.

ORG_STATE: NC

PHR: PROJECT NARRATIVE Chemically modified DNAs are of central importance to both understanding biology and disease and enabling a broad range of biomedical applications and research tools. DNAli Data Technologies, Inc. is developing a novel synthesis platform technology with the potential to incorporate dozens of distinct DNA modifications in fully cus- tomizable patterns. This technology offers orders of magnitude cost improvements over traditional organic syn- thesis processes, can create previously inaccessible modified DNA oligos, and has the potential to significantly accelerate research and development in many areas of biomedicine and biotechnology to benefit public health.

PI_NAMEs: TOMEK, KYLE  (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Acceleration;Address;Alkynes;Amines;aqueous;Area;Biology;Biomanufacturing;Biotechnology;Biotin;Biotinylation;Chemicals;cold temperature;combinatorial;Complex;cost;Data;Devices;Diagnostic;Disease;DNA;DNA biosynthesis;DNA Methylation;DNA Modification Process;DNA Sequence;DNA-Directed DNA Polymerase;Drops;Economics;Endonuclease I;Enzymes;Epigenetic Process;fluorophore;Gene Expression;improved;Industrialization;innovation;Length;Link;Location;magnetic beads;manufacturing process;manufacturing run;Maps;Methods;Modification;Molecular;monomer;novel;Oligonucleotides;Organic Chemistry;Organic Synthesis;Pattern;phosphoramidite;Polymerase;Positioning Attribute;Price;Process;Production;Public Health;Reaction;Reagent;Recycling;Research;research and development;Role;scaffold;sensor;Services;Site;Solvents;synthetic construct;technological innovation;Technology;technology platform;tool;Vendor;Work

PROJECT_TITLE: Innovations to expand and accelerate the commercial impact of DNA modifications


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_CITY: Emeryville

ORG_NAME: ABALONE BIO, INC.

ORG_STATE: CA

PHR: NARRATIVE For G-protein-coupled receptors (GPCRs) such as the mu opioid receptor (MOR), functional agonists capable of receptor activation have been particularly challenging to discover. Abalone Bio proposes to utilize their proprietary platform technology to discover peripheral antibody activators of MOR that induce effective pain relief, while eliminating the related undesirable side effects, such as respiratory depression, constipation, sedation, nausea, dizziness, and even overdose. These antibodies would have the potential to replace the use of dangerous opioids such as fentanyl and to eliminate liabilities associated with these molecules, such as addiction, tolerance and death.

PI_NAMEs: HOHMANN, ANDREA GRACE;TAKEUCHI, TOSHIHIKO  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, TAM L

PROJECT_TERMS: abalone;Absence of pain sensation;abuse liability;Acute Pain;addiction;Adenylate Cyclase;Agonist;Analgesics;Animal Model;Antibodies;antibody libraries;antinociception;AVPR2 gene;beta-arrestin;Binding;Biological Assay;blood-brain barrier crossing;blood-brain barrier penetration;cell growth;Cell Line;Cells;Central Nervous System;Cessation of life;Characteristics;Clinical;CNR2 gene;Codeine;Constipation;Coupled;Cyclic AMP;Dangerousness;Dependence;Dizziness;Dose;Engineering;Family;Fc Receptor;Fentanyl;Freund's Adjuvant;Friends;G-Protein-Coupled Receptors;Growth;GTP-Binding Proteins;Half-Life;Human;in vitro Assay;in vivo;in vivo Model;Inflammatory;inflammatory pain;Mammalian Cell;Morphine;mouse model;mu opioid receptors;Mus;Nausea;Nociception;novel therapeutics;Opioid;Opioid agonist;Opioid Receptor;Outpatients;Overdose;overexpression;Pain;Pain management;pain receptor;pain reduction;pain relief;Pathway interactions;Patients;Peripheral;Peripheral Nervous System;Phase;Physical Dependence;preference;Process;Property;receptor;Receptor Activation;recruit;Risk;Sedation procedure;side effect;Signal Transduction;Signaling Protein;small molecule;Specificity;stable cell line;Tablets;Technology;technology platform;Testing;therapeutic development;Time;Tissues;Toxic effect;Ventilatory Depression;Withdrawal;Work;Yeasts

PROJECT_TITLE: A peripherally restricted MOR agonist for effective pain management with reduced risks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-S (14)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: RANCHO DOMINGUEZ

ORG_NAME: MOLECULAR EXPRESS, INC.

PHR: Public Health Relevance/Project Narrative The development of a lower-cost surfactant would contribute to reducing fatalities resulting from neonatal respiratory distress syndrome across the globe. The performance of the activities proposed in this application is thus expected to have a significant positive impact on public health.

PI_NAMEs: FUJII, GARY  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: 37 weeks gestation;Address;Advanced Development;analytical method;Animals;Biological Assay;Breathing;Bronchoalveolar Lavage;Bronchopulmonary Dysplasia;Case Study;Cause of Death;Cessation of life;Child;Clinic;Continuous Positive Airway Pressure;cost;Cyclic GMP;Development;Devices;efficacy study;Equipment;equipment acquisition;FDA approved;Funding;Future;Guidelines;Health Personnel;Healthcare;Hospitals;Human;improved;in vitro activity;in vivo;Incidence;Infant;infant morbidity/mortality;Infrastructure;intraventricular hemorrhage;lamb model;Life;Lipids;Live Birth;low and middle-income countries;manufacture;manufacturing process;Marketing;Methods;Modeling;Molecular;Morbidity - disease rate;mortality;Neonatal Respiratory Distress;neonate;Nosocomial Infections;Oryctolagus cuniculus;peptide B;peptidomimetics;Performance;Phase;pre-clinical;pre-Investigational New Drug meeting;preclinical development;Pregnancy;premature;Premature Birth;Premature Infant;preterm newborn;Proteins;Public Health;public health relevance;Pulmonary Surfactant-Associated Protein B;Pulmonary Surfactants;Qualifying;Recommendation;Research;respiratory;Risk;Sales;Small Business Innovation Research Grant;stability testing;surfactant;surfactant deficiency;System;Testing;Translating

PROJECT_TITLE: Preclinical Development of a ME-1001, a Synthetic Lung Surfactant

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-B (11)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: AUBURN

ORG_NAME: SYNTRIX BIOSYSTEMS, INC.

ORG_STATE: WA

PHR: Myelodysplastic syndromes (MDS) is a pre-leukemic syndrome to acute myeloid leukemia (AML), with treatment options limited to only 4 drugs with regulatory approval for MDS, including azacitidine and decitabine. Once these agents fail in patients (typically in 1-2 years), there is no second-line treatment, resulting in dismal prognoses: <6 months for higher-risk patients, and <18 months for lower-risk patients. This proposal is a clinical trial wherein the novel, immunotherapeutic drug SX-682 is evaluated in combination with decitabine, which if successful, would dramatically transform the treatment landscape for MDS.

PI_NAMEs: SCHULER, AARON D (contact);ZEBALA, JOHN A

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: Acute Myelocytic Leukemia;Architecture;Azacitidine;Bone Marrow;Cancer Model;chemokine receptor;Clinical;clinical research site;Clinical Trials;cohort;cytopenia;Data;Decitabine;Dependence;Disease;Disease remission;Dose;Dysmyelopoietic Syndromes;Enrollment;Exhibits;Failure;Good Manufacturing Process;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic stem cells;high risk;IL8 gene;IL8RA gene;IL8RB gene;Immunologic Surveillance;Immunotherapeutic agent;Impairment;improved outcome;Inflammatory;inhibitor;Interleukin 8A Receptor;Intravenous;leukemia;leukemic stem cell;Ligands;manufacture;Marrow;Measures;Metastatic Melanoma;Molecular Conformation;Morphology;mutant;novel;Oral;Pancreatic Ductal Adenocarcinoma;participant enrollment;Patients;Pharmaceutical Preparations;Plasma;pre-clinical;Preleukemia;Preparation;progenitor;Prognosis;Publishing;receptor;recruit;Refractory;Relapse;research clinical testing;Resistance;response;Risk;Sampling;Severities;Signal Transduction;Site;Small Business Innovation Research Grant;small molecule;Specific qualifier value;stem;stem cell growth;stem cells;Symptoms;Syndrome;Testing;Time;Transfusion;trial enrollment

PROJECT_TITLE: A Dose Expansion Study of SX-682 Alone and in Combination with Decitabine in MDS Patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (11)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cannabinoid Research;Diabetes;Digestive Diseases;Endocannabinoid System Research;Kidney Disease;Liver Disease

ORG_CITY: BURLINGTON

ORG_NAME: MAKSCIENTIFIC, LLC

ORG_STATE: MA

PHR: OTHER PROJECT INFORMATION - Unit 8 – Project Narrative Diabetic kidney disease (DKD) is a serious public health issue and healthcare burden worldwide, affecting a large proportion of diabetes patients and comprising the majority of cases of chronic kidney disease. This proposal aims to develop novel peripherally acting CB1 neutral antagonists with improved physicochemical properties and enhanced oral bioavailability in a preclinical development program, as a commercial medication for DKD.

PI_NAMEs: ALAPAFUJA, SHAKIRU OLAJIRE (contact)

PROGRAM_OFFICER_NAME: CONAGE-POUGH, JASON EDWARD

PROJECT_TERMS: ABCB1 gene;Affect;Affinity;Agonist;Albuminuria;AM 1241;analog;analytical method;Angiotensin-Converting Enzyme Inhibitors;Animal Model;antagonist;aqueous;Behavioral;Binding;Biological Assay;Biological Availability;Blood Glucose;Blood Pressure;Blood Urea Nitrogen;Brain;Businesses;Caco-2 Cells;Cells;Chronic Kidney Failure;Clinical;Clinical Markers;Clinical Research;CNR1 gene;CNR2 gene;commercialization;Computer Assisted;Creatinine;Cyclic AMP;cytotoxic;Data;design;Development;Diabetes Mellitus;diabetic;Diabetic Nephropathy;diabetic patient;diabetic rat;disease model;Dose;drug candidate;Drug Design;drug development;Drug Industry;Drug Kinetics;Dyslipidemias;efficacy evaluation;efficacy study;efficacy validation;Enalapril;End stage renal failure;Ensure;Evaluation;experience;Fatty Liver;Fibrosis;Formulation;Funding;Future;gastrointestinal;Glomerular Filtration Rate;glomerulosclerosis;Grant;healthcare burden;Hepatocyte;Human;Hyperglycemia;Hypertrophy;improved;In Vitro;in vivo;in vivo evaluation;indexing;Inflammation;Informatics;Injury;Kidney;Kidney Diseases;kidney fibrosis;Laboratories;Lead;lead candidate;Liver;Metabolic;Metabolic syndrome;method development;Microsomes;Modeling;Modification;nephrin;non-diabetic;novel;novel therapeutics;Oral;Pathogenesis;Patients;Perindopril;Peripheral;Permeability;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase;Plasma;Plasma Proteins;podocyte;pre-Investigational New Drug meeting;preclinical development;Preparation;Process;Production;Program Development;programs;Property;Public Health;Renal function;Renin;Rodent;Safety;scale up;Schedule;Sclerosis;Series;Small Business Innovation Research Grant;Solubility;Structure;success;Symptoms;Testing;Toxicology

PROJECT_TITLE: A CB1 Antagonist for Treatment of Kidney Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-R (11)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: EUGENE

ORG_NAME: NORTHWEST PREVENTION SCIENCE INC

ORG_STATE: OR

PHR: Project Narrative In this study, we propose to culturally adapt the online version of Family Check-Up and identify strategies to reduce barriers to engagement and support effectiveness using a community-engaged approach. We will use a mixed-methods approach to guide adaptation of the online model through interviews with community leaders. Our team will assess feasibility, accessibility, and commercial potential of the adapted intervention, with the goal of targeting key parenting mechanisms (parenting practices and cultural socialization) to improve youth mental health and inform broad public health efforts to reduce mental health disparities.

PI_NAMEs: DOTY, JENNIFER L;REITER, LISA ANN (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;Adolescent;adolescent mental health;Adult;aged;Anxiety;Attitude;behavioral health;behavioral health intervention;Benchmarking;checkup examination;Child;Child Mental Health;Child Rearing;Clinical Trials;commercialization;Communities;community engaged approach;Community Health Aides;community research;community setting;Consumer Satisfaction;coping;cost;Coupled;Data;design;Development;digital;digital health;digital technology;Disease;Distress;effectiveness testing;Emotional;ethnic minority population;evidence base;Evidence based intervention;experience;externalizing behavior;Family;feasibility testing;Feedback;Future;Goals;Health Benefit;health disparity;Health Technology;Hispanic;hispanic community;Hispanic Populations;Immigrant;implementation strategy;Improve Access;improved;improved outcome;Incentives;Intervention;Interview;junior high school;Latinx;lifetime risk;Link;marginalization;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methods;Modeling;Monitor;National Institute on Minority Health and Health Disparities;Not Hispanic or Latino;Online Systems;online version;Outcome;parenting intervention;Parents;Phase;phase 1 study;Pilot Projects;pilot trial;Population;prevent;Problem behavior;Problem Solving;Process;programs;promote resilience;Public Health;racism;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Reduce health disparities;Reporting;Research;Research Personnel;resilience;Resources;Risk;Sampling;scale up;skills;Small Business Innovation Research Grant;social culture;social health determinants;Socialization;socioeconomics;Source;Spanish;stressor;Stretching;Surveys;Symptoms;Techniques;Technology;telehealth;Thinness;uptake;usability;Use Effectiveness;web app;web portal;Youth

PROJECT_TITLE: Cultural Adaptation of Family Check-Up to Reduce Health Disparities and Improve MentalHealth among Hispanic Families

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 JT (J1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: ISONO HEALTH, INC.

PHR: PROJECT NARRATIVE Breast cancer (BC) accounts for approximately 30% of all new female cancer diagnoses in the United States. Early disease detection is paramount for better prognosis and increased survival rates, but conventional mammogram suffers from poor sensitivity in women with dense breasts, as well as inaccessibility to underserved populations. To address these issues, iSono Health has developed the ATUSA imaging and AI-assisted diagnostic platform, which is a scalable, efficient, and cost-effective supplemental BC screening method that can be deployed in the primary care setting.

PI_NAMEs: SABERI, SHADI  (contact)

PROGRAM_OFFICER_NAME: LOU, XING-JIAN

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;Address;Adherence;Affect;Age;Agreement;Algorithms;Artificial Intelligence;artificial intelligence model;automated segmentation;Benign;Biopsy;black women;Breast;Breast Cancer Detection;breast cancer diagnosis;Breast Cancer Early Detection;breast density;breast imaging;breast scan;cancer diagnosis;Case Study;Cause of Death;Classification;Clinical;clinical diagnosis;clinical efficacy;cloud based;cohort;Collection;commercial launch;cost effective;Coupled;density;Detection;Development;Devices;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic platform;Disease;Distant;Drops;Early Diagnosis;Early identification;Enrollment;Equity;Exhibits;experience;Female;Fibroadenoma;Fright;General Population;global health;Goals;Grant;Health;health care availability;Image;Imaging Device;imaging facilities;imaging platform;Imaging Techniques;improved;Incidence;innovation;Legal patent;Lesion;Life;Longitudinal Studies;machine learning algorithm;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Ultrasonography;Mammographic screening;Mammography;Masks;Measurement;Measures;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;Noninfiltrating Intraductal Carcinoma;novel;novel strategies;Outcome;overtreatment;Pain;patient oriented;patient population;Patients;Performance;Phase;Physicians;point of care;Population;portability;prevent;Primary Care;primary care setting;Probability;Prognosis;prospective;Radiation;radiologist;Reader;Reading;Recommendation;Reproducibility;Research;Resource-limited setting;Rural;Rural Population;Scanning;Schedule;screening;screening guidelines;Screening procedure;Site;skills;socioeconomic disparity;standard of care;statistics;success;supplemental screening;Survival Rate;System;Technology;Three-Dimensional Image;three-dimensional modeling;Time;Tissues;Training;Treatment outcome;triple-negative invasive breast carcinoma;Ultrasonography;ultrasound;Underrepresented Populations;Underserved Population;United States;United States Preventative Services Task Force;Validation;Visualization;wearable device;White Women;Woman;Women's mortality

PROJECT_TITLE: ATUSA: World's First Wearable and Automated 3D Breast Ultrasound System with AI

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-Z (10)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: OAKLAND

ORG_NAME: DYNAMOID, INC.

PHR: Immersive virtual reality (VR) holds great promise for improving student engagement and scientific understanding, but producing VR content that is interactive, accurate, and tailored to different curricula has until now required specialists with expertise in curriculum development, software development, and design. Dynamoid's 10k is a pioneering data visualization platform that empowers scientists, educators, and researchers to create their own VR experiences–based on real data–without having to learn any coding or design skills. Dynamoid seeks to foster deeper student engagement in life sciences, enhance content understanding, and, in the long term, inspire more students to pursue STEM careers, as well as cultivate a scientifically literate society equipped to tackle future challenges.

PI_NAMEs: GONZALEZ, LAURA LYNN (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Acceleration;Active Learning;Affect;base;Biological Sciences;Code;Collection;Communication;Country;COVID-19 pandemic;CRISPR therapeutics;curriculum development;dashboard;Data;data visualization;design;Development;Devices;Documentation;Education;Educational Curriculum;Educational process of instructing;Educational Status;efficacy validation;empowerment;Environment;experience;falls;Feedback;Fostering;Future;Genomics;Goals;graduate school;Guidelines;high school;improved;innovation;interest;Internet;Knowledge;Knowledge acquisition;Learning;Libraries;Licensing;Mathematics;Methods;model development;Modeling;Motivation;Outcome;Ownership;Participant;Phase;pilot test;planetarium;Process;Production;prototype;Reading;Research;Research Personnel;Running;Sampling;scale up;Schools;Science;science education;scientific literacy;Scientist;Self Efficacy;Sickle Cell Anemia;skills;Societies;software development;Specialist;STEM career;STEM field;student participation;Students;teacher;Teaching Method;Testing;Text;Thinking;Time;tool;Update;virtual reality;virtual reality environment;Vision;Visualization

PROJECT_TITLE: 10k: A platform for immersive science education

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (56)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Health Services;Mental Health;Mental Illness;Pediatric;Telehealth

ORG_NAME: MAINSQUARE CO

PHR: Narrative - Remote teletherapy can help enable more accessible, convenient, and lower-cost care for children but clinicians working with children remotely experience low in-session engagement. Low engagement is tied to worse clinical outcomes in children and reduced revenue for health systems due to no-shows, treatment drop- out, and therapist distress / provider turnover. In-session engagement – active involvement in an intervention – is associated with improved outcomes for depression, anxiety, and substance disorders. Teleo is developing a remote behavioral therapy platform that enhances engagement specifically in the pediatric and adolescent cohorts to improve outcomes and increase access to care.

PI_NAMEs: HONG, DAVID S (contact);KUHN, ERIC ROLAND

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Address;Adolescent;Adopted;Adoption;Affective;Age;Anxiety;Area;arm;Attitude;automated treatment planning;Behavior Therapy;Behavioral;behavioral health;care costs;care outcomes;Caregivers;Child;childcare allowance;Childhood;Client;Clinic;Clinical;Code;Cognitive;cohort;Communities;Community Health Systems;Conceptual Domain;Control Groups;Data;Development;Dimensions;Disease;Distress;Documentation;Dropout;Early treatment;Effectiveness;evidence base;Evidence based practice;experience;Feedback;Focus Groups;Funding;Health;Health Insurance Portability and Accountability Act;Health Personnel;Health Services Accessibility;Health system;improved;improved outcome;interest;Intervention;Interview;Libraries;Link;Marketing;Measures;Medicaid;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Outcome;patient engagement;Patient-Focused Outcomes;Patients;pediatric patients;Performance;Pharmaceutical Preparations;Phase;Population;Provider;Psychotherapy;Randomized;Randomized, Controlled Trials;recruit;research and development;satisfaction;Self Efficacy;Small Business Technology Transfer Research;social;standard of care;Standardization;success;Surveys;Technology;telehealth;Teletherapy;Time;tool;treatment duration;Trust;Update;Validation;Video Recording;Videoconferencing;virtual;virtual environment;virtual therapy;virtual visit;Youth

PROJECT_TITLE: Engagement and clinical impact of the Teleo virtual therapy platform in clinical settings

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-C (10)]


NIH_SPENDING_CATS: Asthma;Bioengineering;Climate-Related Exposures and Conditions;Clinical Research;Lung;Nanotechnology;Patient Safety;Pediatric;Prevention

ORG_CITY: SAN DIEGO

ORG_NAME: AQUILLIUS CORPORATION

PHR: Project Narrative Climate change and environmental pollutants have been identified as major contributors to rising asthma rates, which already affects over 300 million people globally. Asthma diagnosis is particularly difficult in children and current methods are not optimized for or compatible with younger children under the age of 5. Aquillius Corporation proposes to develop a non-invasive respiratory sensor that is capable of real-time, continuous monitoring and measuring of pulmonary function to improve diagnosis, patient care, and outcomes for asthmatic youth.

PI_NAMEs: LE, MYPHUONG T (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: accurate diagnosis;Adolescent;Adult;Affect;Age;Air Movements;airborne allergen;airway hyperresponsiveness;airway obstruction;algorithm development;Algorithms;Allergens;American;Area;Asthma;asthmatic;asthmatic patient;Biomedical Research;Bluetooth;Breathing;California;Characteristics;Chest;Child;Childhood;Chronic;climate change;Clinical Trials;commercialization;Communication;Computer software;cost;cost effective;Coupled;Data;design;Detection;Development;Devices;Diagnosis;Disease;Early Diagnosis;Economic Burden;electrical impedance tomography;Environmental Pollutants;Exhalation;experience;experimental study;family burden;Feasibility Studies;Film;flexibility;Future;global temperature;Goals;graphene;Human;improved;innovation;insight;Instruction;Jogging;Lung;lung volume;Manikins;manufacture;Maps;Measurement;Measures;Methods;microelectronics;mid-career faculty;Modeling;Monitor;Movement;nanomaterials;nanosheet;Nanotechnology;Noise;Obstruction;operation;Outcome;Output;Parents;Patient Care;Patient Monitoring;patient safety;Patients;pediatrician;Persons;Phase;phase 1 study;Physical Examination;Pollen;portability;Principal Investigator;programs;Property;Provider;pulmonary function;Pulmonary function tests;Questionnaires;Research;respiratory;Respiratory Disease;Respiratory physiology;Seasons;sensor;Severity of illness;Signal Transduction;simulation;Spirometry;Symptoms;Technology Assessment;Testing;Thinking;Thinness;Time;timeline;tool;United States;Universities;usability;Validation;Vulnerable Populations;wearable device;wearable sensor technology;Youth

PROJECT_TITLE: Wearable Graphene Respiratory Sensor for Early Detection and Monitoring of Asthma


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care

ORG_CITY: DANA POINT

ORG_NAME: IVOS MEDICAL, INC.

PHR: Narrative Endotracheal intubation (breathing tube placement), a daily and vital life-saving procedure, often faces challenges when video laryngoscope cameras are obscured by bodily fluids like blood or gastric contents. IVOS Medical is addressing this issue by developing an economical, single-use video laryngoscope sleeve. This novel device ensures clear vision throughout the intubation process.

PI_NAMEs: PUNSALAN, GABRIEL  (contact)

PROJECT_TERMS: Accident and Emergency department;Address;Adherence;Adult;Anesthesiology;aspirate;Blood;Body Fluids;Breathing;Cadaver;California;Catheters;clinic ready;Clinical;Clinical Research;commercialization;Critical Illness;design;Development;Devices;Distal;economic outcome;Effectiveness;Emergency Medicine;Emergency Situation;Ensure;Environmental Wind;Evaluation;Face;Failure;Feasibility Studies;feasibility trial;Feedback;Goals;Good Manufacturing Process;Health;Health Benefit;Health Personnel;Health Professional;high risk;Hospitals;Human;Hypoxia;improved;Industry;Institution;instrument;Intensive Care;Intensive Care Units;Intervention;Intratracheal Intubation;Intubation;Knowledge;Laryngoscopes;Laryngoscopy;lens;Life;Liquid substance;Lung;Manikins;manufacture;Manufacturer;manufacturing process;Measures;Medical;Medical center;Medical Device;Monitor;Names;novel;Operating Rooms;Operative Surgical Procedures;Oral cavity;Oxygen;Pathway interactions;patient oriented;Patient-Focused Outcomes;Patients;Perioperative Care;Phase;Pilot Projects;pre-clinical;preclinical study;prevent;Procedures;Process;Protocols documentation;Quality Control;Research;Research Proposals;Risk;Safety;safety assessment;Secure;Small Business Innovation Research Grant;Soil;Solid;Specialist;Speed;standard of care;statistics;Stomach;success;Suction;Surface;System;Testing;Time;tool;Tube;United States National Institutes of Health;Universities;Validation;validation studies;Vision;Visual Fields;Visualization;vocal cord;Vomiting

PROJECT_TITLE: IVOS Medical: Intubation, Optimized.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-S (11)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: PORTOLA VALLEY

ORG_NAME: TAKEOFF41, INC.

PHR: Project Narrative The current total parenteral nutrition (TPN) administration process involves multiple parties, which makes it inefficient, costly, and prone to potentially fatal errors. In this work, TAKEOFF41 INC. (dba Takeoff AI) propose to address these issues by developing an AI-driven TPN platform with standardized TPN compositions to a certain number of units that allows mass manufacturing while still maintaining the same personalization performance as individualized prescriptions. Overall, the work contained herein has a direct translational impact in utilizing advanced AI and our unique data collected over 10 years to provide personalized TPN that has lower cost and error rates, higher accessibility, and improved long-term outcomes.

PI_NAMEs: AGHAEEPOUR, NIMA ;PHONGPREECHA, THANAPHONG  (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Address;Admission activity;adverse outcome;Artificial Intelligence;artificial intelligence model;authority;Birth;blind;Caring;Caseins;Child;Childhood;Cholestasis;Clinical;cohort;commercialization;Computer software;Consultations;cost;cost effective;cost efficient;Cost Savings;Data;Data Set;demographics;Development;Electronic Health Record;Ensure;Enteral Feeding;Evaluation;feeding;Formulation;Future;Goals;Growth;Health;Health Professional;high risk infant;Hospitals;human error;improved;Incidence;Income;Individual;Infant;Intervention;Life;Link;Live Birth;Low income;low income country;manufacture;Marketing;Methods;Modeling;Morbidity - disease rate;National Institute of Child Health and Human Development;Nature;Neonatal;neonatal care;Neonatal Intensive Care Units;Neurodevelopmental Impairment;Newborn Infant;novel strategies;Nutrient;nutrition;Outcome;Parenteral Nutrition;Pediatric Hospitals;Performance;personalized nutrition;Phase;Positioning Attribute;pre-trained transformer;premature;Premature Infant;preterm newborn;Process;Production;programs;Publishing;Regulatory Pathway;Risk;Safety;Sales;Sepsis;Site;Small Business Innovation Research Grant;Small Business Technology Transfer Research;software as a medical device;software development;standard of care;Standardization;System;Testing;Time;Total Parenteral Nutrition;transfer learning;translational impact;United States;United States Food and Drug Administration;Universities;Validation;validation studies;Vulnerable Populations;Work

PROJECT_TITLE: An AI-driven total parenteral nutrition platform for cost-effective and scientifically personalized nutrition for premature newborns

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (14)]


ORG_CITY: Newark

ORG_NAME: MEDFREE, INC.

PHR: Public Health Relevance Statement / Project Narrative Mitral valve regurgitation affects more than 7 million people or approximately 2-3% of the population in the United States alone, of whom about 3.8 million suffer from moderate to severe regurgitation, with as high as 1.7 million patients in need of immediate treatment, and new diagnoses increasing by about 250 thousand each year. However, only about 50 thousand undergo surgical treatment each year due to the high risk associated with the surgical procedure, and although significantly safer only about 150 thousand patients have undergone catheter based interventional treatment, as the currently available interventional procedures are extremely difficult to perform. In this project, MEDFREE® Inc., will build a safe, easy to use, and innovative 12F percutaneous catheter-based interventional device that leverages the Transcatheter Edge-to-Edge Repair technique to address this severely unmet clinical need, which is a market that is currently estimated to be over $6 billion USD by 2028.

PI_NAMEs: BASUDE, RAGHUVEER  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Address;Affect;Anatomic Models;Animals;Catheters;Cessation of life;Clinical;Clinical Research;Clinical Trials Data Monitoring Committees;cohort;commercialization;commercialization readiness;comorbidity;Contracts;cost;COVID-19 impact;COVID-19 pandemic;Data;design;design verification;Devices;Documentation;Equipment and supply inventories;Evaluation;Fatigue;FDA approved;Feasibility Studies;Femoral vein;frailty;Freezing;Funding;Goals;Government;Heart;high risk;Human;improved;in vitro Model;in vitro testing;Individual;Informed Consent;innovation;Institutional Review Boards;Intervention;Investigation;Length;Magnetic Resonance Imaging;manufacture;Marketing;meetings;Mitral Valve;Mitral Valve Insufficiency;Monitor;new technology;Newly Diagnosed;Notification;novel;Operative Surgical Procedures;Patients;Persons;Phase;Physicians;Population;porcine model;post-COVID-19;pre-clinical;Preparation;Procedures;Process;programs;Protocols documentation;prototype;public health relevance;repaired;Reporting;research and development;Research Contracts;Risk;Sample Size;Secure;Septal Vein;Site;System;Techniques;Technology;Testing;United States;United States National Institutes of Health;Writing

PROJECT_TITLE: Novel Self-closing 12F Mitral Valve Repair System to Percutaneously Treat Moderate to Severe Regurgitation Using Transcatheter Edge-to-Edge Repair (TEER) Technique Via Femoral Vein Access.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (19)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Rehabilitation;Telehealth

ORG_NAME: COLLINGE AND ASSOCIATES

PHR: Project Narrative Chemotherapy-induced peripheral neuropathy (CIPN) impairs quality of life and functioning in millions of cancer survivors. Evidence from research and practice in the field of Oncology Massage (OM) indicates that CIPN symptoms can respond positively to specific manual therapy methods tailored to CIPN. This Phase II project will complete development of the first evidence- based education program to teach lay caregivers OM-informed techniques for use at home to reduce symptoms and disability from CIPN in cancer survivors. The instruction is delivered by mobile app and will be evaluated in a three-arm randomized controlled trial to assess outcomes for both CIPN sufferers and caregivers using the intervention.

PI_NAMEs: COLLINGE, WILLIAM B. (contact);TOFTHAGEN, CINDY

PROGRAM_OFFICER_NAME: DJEMIL, SARRA

PROJECT_TERMS: Address;Age;arm;attentional control;Attitude;Back;burden of illness;cancer care;cancer complication;Cancer Survivor;cancer therapy;caregiver education;caregiver interventions;Caregivers;caregiving;Caring;chemotherapy;Chemotherapy-induced peripheral neuropathy;Chronic;cost;daily functioning;design;Development;disability;Distress;Economic Burden;Education;education resources;Educational process of instructing;eHealth;Etiology;evidence base;family burden;Family Caregiver;Family member;feasibility testing;Feedback;Focus Groups;Head;Health Benefit;Home;human centered design;Impairment;improved;Incidence;innovation;Instruction;Intervention;Language;Life;loved ones;Manipulative Therapies;Manuals;Massage;Medical Care Costs;Methods;mHealth;mobile app development;mobile application;Mobile Health Application;Motivation;Neck;Oncology;Outcome;Outcome Assessment;Patients;Peripheral Nervous System Diseases;Personal Satisfaction;Phase;phase 1 study;Physical Function;Population;prevent;Process;Productivity;programs;prototype;Public Health;Qualifying;Quality of life;quality of life for cancer survivors;Randomized, Controlled Trials;Recommendation;reduce symptoms;Relaxation;Reporting;Research;Risk;Role;Sampling;Series;Services;Shoulder;skills;Supportive care;Symptoms;Techniques;Testing;treatment as usual;Treatment Side Effects;usability;Waiting Lists

PROJECT_TITLE: mHealth app for caregiver instruction in manual therapy for chemotherapy-induced peripheral neuropathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-J (10)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

PHR: At least 10% of Veterans seeking help for auditory difficulties in VA Audiology clinics are found to have normal hearing sensitivity. Identifying the cause of auditory processing problems in these Veterans and determining effective rehabilitation strategies is a significant challenge for clinicians. A survey of VA Electronic Medical Records data found that approximately 20% of the Veteran population had a diagnosis of obstructive sleep apnea (OSA) in 2021. OSA is associated with several health conditions including cognitive deficits, cardiovascular disease and an increased likelihood of hearing loss and tinnitus. If OSA is associated with auditory functional difficulties, these deficits are likely to present before the onset of permanent hearing loss. Early identification of auditory difficulties associated with OSA may provide a novel route for improved auditory function via continuous positive airway pressure (CPAP) therapy, one which may also help to mitigate or prevent future development of permanent hearing impairment.

PI_NAMEs: PAPESH, MELISSA  (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Adult;Affect;Age;American;Apnea;Audiology;Auditory;auditory pathway;Auditory Perceptual Disorders;auditory processing;Auditory system;Award;behavior measurement;Brain;Brain Stem;Cardiovascular Diseases;Cerebrovascular Disorders;Clinic;Clinical;clinical care;clinical predictive model;Clinical Trials;Cochlea;Cognition;Cognitive deficits;Communication difficulty;comparison control;Computerized Medical Record;Continuous Positive Airway Pressure;Counseling;Data;deprivation;design;Development;Diabetes Mellitus;Diagnosis;Diagnostic tests;disability;Early identification;Event;Event-Related Potentials;Excessive Daytime Sleepiness;Failure;Foundations;Frequencies;Functional disorder;functional improvement;Future;Goals;Health;Hearing;hearing impairment;Hearing problem;Hearing Tests;help-seeking behavior;High Prevalence;Hypercapnia;Hypoxemia;Hypoxia;improved;indexing;Inflammation;interdisciplinary collaboration;Investigation;Learning;Measurable;Measures;Medical;Medical center;Medicine;Mental Depression;military veteran;Modeling;normal hearing;novel;Obstructive Sleep Apnea;Oxidative Stress;Oxygen;Participant;Patient Recruitments;Patient Self-Report;Patients;Peripheral;permanent hearing loss;personalized care;Physiological;Polysomnography;Post-Traumatic Stress Disorders;predictive modeling;prevent;programs;Quality of life;Questionnaires;Recommendation;recruit;Recurrence;rehabilitation strategy;Rehabilitation therapy;Research;response;Role;Route;secondary analysis;Severities;Sleep;Sleep Apnea Syndromes;Snoring;sound;Source;Specialist;standard measure;Surveys;Test Result;Testing;Tinnitus;Tissues;United States National Institutes of Health;Veterans;Work

PROJECT_TITLE: Auditory Effects of Sleep Apnea and CPAP Therapy

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Patient Safety;Prevention

ORG_CITY: Portland

ORG_NAME: ARONORA, INC.

PHR: Project Narrative There is a critical unmet medical need for drugs that can prevent blood clots without any bleeding side-effects. This unmet need is especially important in cancer patients who require central venous catheter line placement to receive life-saving therapies and who are prone to blood clots. The proposed research directly addresses this need by clinical evaluation and development of a unique drug candidate, AB023 (gruticibart), which has been shown in primate studies and early human trials to potently inhibit blood clot formation without bleeding side-effects, and therefore has the potential to safely prevent central venous catheter-related clots in cancer patients.

PI_NAMEs: LORENTZ, CHRISTINA U (contact);TUCKER, ERIK IAN

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: Achievement;Acute;Address;Adverse effects;Adverse event;Anti-Inflammatory Agents;Antibodies;Anticoagulants;Anticoagulation;Antidotes;Antiplatelet Drugs;Award;Binding;Biocompatible Materials;Biological Products;blocking factor;Blood;Blood coagulation;Bypass;C-reactive protein;Cancer Patient;cancer therapy;Cardiovascular system;catheter related infection;Catheters;Chimera organism;Chronic;Clinical;clinical development;Clinical Research;Clinical Trials;clinically relevant;Coagulation Process;Complex;Cytotoxic Chemotherapy;Data;Dedications;Deep Vein Thrombosis;Detection;Development;Devices;Disease;Dose;Dose Limiting;Double-Blind Method;drug candidate;Drug Targeting;Drug usage;efficacy outcomes;Embolism;Emergency Situation;End stage renal failure;Equipment Malfunction;Event;experience;Factor XI;Factor XII;Feedback;Fibrinolytic Agents;Goals;Hemodialysis;Hemorrhage;Hemostatic Agents;Hemostatic function;Human;Immunoglobulin Idiotypes;Impairment;Implantable venous access port;Incidence;Individual;Infection;Inflammatory;inhibitor;innovation;Intervention;Legal patent;Life;Malignant Neoplasms;Marketing;Measures;Medical;Medical Device;Monitor;neutralizing antibody;novel;Observational Study;Operative Surgical Procedures;Outcome Measure;Pathway interactions;Patient Care;patient population;Patients;Peripheral;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phase II Clinical Trials;phase II trial;Placebo Control;placebo controlled study;Placebos;Plasma;Prekallikrein;preservation;prevent;Prevention;Primates;product development;prophylactic;Randomized;Recombinants;Reporting;Research;research clinical testing;Research Personnel;Risk;Risk Factors;Safety;safety outcomes;safety testing;Secure;Sepsis;side effect;Small Business Innovation Research Grant;Stream;success;Supportive care;System;targeted treatment;Testing;Therapeutic Agents;Therapeutic Embolization;Thrombin;Thrombophilia;Thrombosis;thrombotic;Thrombus;Time;Toxic effect;trial planning;ultrasound;Venous

PROJECT_TITLE: Contact Pathway Inhibitor to Prevent Catheter-Related Thrombosis


ORG_CITY: EDMONDS

ORG_NAME: SENSORIIS, INC.

PHR: Project Narrative This Phase I project develops a stand-alone system to acquire and analyze the heart beating videos of embryonic zebrafish, providing cardiac functions in the most accurate, efficient and rapid manner.

PI_NAMEs: CAO, HUNG ;LAU, MICHAEL P.H. (contact)

PROJECT_TERMS: 3-Dimensional;3D Print;Adult;Algorithms;Animal Model;Authorization documentation;Businesses;Cardiac;cardiogenesis;Cardiology;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;Cloud Computing;Collaborations;Computers;congenital heart abnormality;Consumption;cost;Data;deep learning;Development;Developmental Biology;developmental genetics;Dimensions;drug discovery;Drug Screening;Economics;EFRAC;Electrocardiogram;Electrodes;Electroencephalography;Electronics;Electrophysiology (science);Embryo;Fishes;flexibility;functional genomics;Future;Generations;Genetic;genetic approach;Genome;Health Expenditures;Heart;Heart Diseases;heart function;Heart Rate;Housing;Human;Image;improved;interest;Label;Laboratory Research;Maintenance;Manuals;Measures;Methods;Microscopic;Modeling;Modernization;Molecular;Morbidity - disease rate;Morphology;mortality;Names;novel;operation;Optics;Organ;Persons;Pharmaceutical Preparations;Phase;Phenotype;Physiology;Positioning Attribute;Process;reconstruction;Research;research and development;Research Personnel;Sampling;Secure;Signal Transduction;Study models;success;System;Testing;Therapeutic;Time;Translating;two-dimensional;United States National Institutes of Health;Vascular System;Ventricular;Work;Zebrafish

PROJECT_TITLE: Novel Acquisition and Computation of Cardiac Functions in Developing Zebrafish Embryos


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: EQUITI FOODS, LLC

PHR: NARRATIVE Low-socioeconomic status, ethnic and racial minority status, and rural residence are strong predictors of poor  health and food insecurity; thus, there is a critical need to recognize these disparities and the impact they have  on individual and community wellbeing and productivity, and to create opportunities for improved nutrition  through comprehensive solutions. Implementation of a “Food is Medicine” approach has been developed as an  effective strategy to address diet-related disease by increasing access and therefore the ability to consume  healthy food. Equiti Foods proposes to expand the Good Bowls model to support “Food is Medicine” programs that will tap into existing reimbursement initiatives to bring healthy and medically tailored meals to underserved  groups at low or no cost in an effort reduce health disparities while maintaining a viable business model.

PI_NAMEs: AMMERMAN, ALICE S (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Advisory Committees;Black Populations;Black, Indigenous, People of Color;Businesses;Cardiovascular Diseases;Cause of Death;Child;Chronic Disease;Client;Communities;Conscious;Consumption;cost;Cost Savings;design;Diabetes Mellitus;Diet;dietary;Disease;disorder risk;Disparity;Economic Development;Economics;education resources;Eligibility Determination;ethnic minority;ethnic minority population;ethnic minority status;evidence base;experience;Family;Farm;farmer;feasibility testing;Food;food insecurity;food security;Food Webs;Freezing;Friends;Funding;Future;Generations;Health;Health Care Costs;health disparity;health equity;Health Food;Health Professional;Healthcare Systems;Heart Diseases;high risk;Hispanic Populations;Hypertension;implementation science;improved;Individual;Insurance;insurance plan;Intervention;Job loss;Life;Life Style;Link;Lived experience;Liver diseases;local economy;Low Income Population;low socioeconomic status;Medicaid;Medical;medically underserved;Medicare;Medicine;Mediterranean Diet;Methods;Mission;Modeling;neighborhood disadvantage;Non-Insulin-Dependent Diabetes Mellitus;North Carolina;Not Hispanic or Latino;nutrition;Nutritional;Obesity;pandemic disease;Patients;Pattern;Personal Satisfaction;Phase;Privatization;Production;Productivity;Program Description;programs;Protocols documentation;Public Health;racial minority;racial minority status;Recipe;Reduce health disparities;Research;Rural;Rural Community;rural residence;rural underserved;scale up;Seasons;service providers;socioeconomics;source localization;stressor;Taste Perception;Taste preferences;Testing;Underserved Population;waiver;web platform

PROJECT_TITLE: Achieving health equity through food as medicine and medically tailored meals: local economic opportunity


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Muscular Dystrophy;Rare Diseases

ORG_CITY: Mukilteo

ORG_NAME: KINEA BIO, INC.

PHR: PROJECT NARRATIVE Gene therapies using AAV vectors are very promising, but many genes involved in genetic disorders are too large to be transported by these potent vectors. Kinea Bio and its partners developed a novel therapeutic approach that allows the delivery and expression of large proteins. In this project, we will validate this novel strategy in limb-girdle muscular dystrophy 2b in a preclinical and IND-enabling study to prepare for future clinical trials.

PI_NAMEs: CHILDERS, MARTIN K (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: 3-Dimensional;Address;adeno-associated viral vector;Animal Model;Animals;Biodistribution;C-terminal;Clinical;Clinical Trials;Code;Complementary DNA;Development;Disease;Dose;DYSF gene;dysferlinopathies;Dystrophin;effectiveness validation;Exclusion;Future;gene therapy;Gene Transfer;Genes;Genetic;Genetic Diseases;Genetic Medicine;Genetic Recombination;Human;human induced pluripotent stem cells;In Vitro;in vivo;Injections;intein;Intravenous;Length;Ligation;Limb-Girdle Muscular Dystrophies;Mediating;Methods;micro-dystrophin;miniaturize;Modality;Modeling;Mus;Muscle;muscle engineering;Muscular Dystrophies;Myoblasts;Myocardium;Myopathy;novel;novel strategies;novel therapeutic intervention;Open Reading Frames;Peptides;Phase;Physiological;Plasmids;pre-clinical;Proteins;Rare Diseases;reconstitution;Regimen;Skeletal Muscle;stoichiometry;Striated Muscles;System;Testing;Therapeutic;Tissues;Trans-Splicing;transduction efficiency;Transfection;vector;Viral;Viral Genes;Viral Genome;Viral Vector

PROJECT_TITLE: Development of novel genetic medicine approaches to treat orphan diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-D (10)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: 3D BIOANALYTIX, INC.

PHR: Project Narra+ve STTR An es+mated 6.7 million people live with Alzheimer’s in the US, with Alzheimer and Alzheimer- related diseases being one of the leading causes of death. Yet, a lack of molecular diagnos+c tests to diﬀeren+ate and detect these diseases early on means that diagnosis typically occurs only when demen+a symptoms become apparent and brain damage is already severe, and which has also hindered the development of eﬀec+ve therapies. Here, we propose to use a novel technology called covalent protein pain+ng (CPP) to develop a blood-based diagnos+c test that can for the ﬁrst +me directly iden+fy and quan+fy the characteris+c misfolded protein aggregates thought to exist decades before onset of symptoms and that holds promise to deliver a diﬀeren+al and early diagnosis for several neurodegenera+ve diseases.

PI_NAMEs: PANKOW, SANDRA  (contact);YATES III, JOHN R

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: abeta accumulation;Acceleration;Affinity;Affinity Chromatography;alpha synuclein;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease patient;Amyloid beta-Protein;Antibodies;Autopsy;Biological Assay;Biological Markers;Blinded;Blood;Blood specimen;Brain;Brain Injuries;Cause of Death;Cells;Cessation of life;Chemicals;clinical trial participant;Clinical Trials;cognitive testing;cohort;cost;Data;Databases;Dementia;Detection;Development;Diagnosis;Diagnostic;diagnostic biomarker;Diagnostic tests;diagnostic tool;Disease;Early Diagnosis;Eating;Ensure;Frontotemporal Dementia;Funding;Impaired cognition;improved;Intervention;invention;Label;Lewy Body Disease;Mass Spectrum Analysis;Measures;Memory Loss;Methods;mild cognitive impairment;minimally invasive;misfolded protein;Molecular;Molecular Diagnostic Testing;molecular diagnostics;Monitor;Nerve Degeneration;Neurodegenerative Disorders;new technology;novel;Pain;Paint;Parkinson Disease;Participant;participant enrollment;Partner in relationship;patient stratification;Patients;Peptides;Perchloric Acids;Persons;Pharmaceutical Preparations;Phase;Physical Examination;Physicians;Plasma;Plasma Proteins;Populations at Risk;Precipitation;Primary Care Physician;protein aggregation;Protein Analysis;protein biomarkers;Protein Conformation;protein folding;protein TDP-43;Proteins;Reaction;Reporting;Reproducibility;Sampling;Small Business Technology Transfer Research;success;Surface;Symptoms;Syndrome;tau Proteins;technology platform;Testing;Therapeutic;tool;Work

PROJECT_TITLE: Development of a blood-based test for neurodegenerative diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-H (13)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: ALBUQUERQUE

ORG_NAME: ACTOPROBE, LLC

ORG_STATE: NM

PHR: Narrative New infectious disease diagnostic approaches are required to improve diagnostic speed, reliability, and detection sensitivity, ideally for label-free disease-causing agent detection directly from patient samples. Characterization of single DNA and RNA at the single-molecule level, however, remains unattainable due to the lack of applicable technologies that can reach single-molecule resolution and chemical sensitivity. This project will develop a novel class of scanning probe microscopy near-field optical probes that will provide new and enhanced research capabilities for studying biochemical components of viruses, bacteria, fungi, and other microorganisms and their morphology, ultrastructure, and nanomechanical properties, with the ultimate goal to enable very long fragments of DNA /RNA sequencing with no previous information about the organisms to do early infection detection and identification.

PI_NAMEs: AMOSOVA, OLGA A;UKHANOV, ALEXANDER A (contact)

PROGRAM_OFFICER_NAME: ASHMONT, KARI RICH

PROJECT_TERMS: Address;Air;Antibodies;Area;Aspergillus fumigatus;Bacteria;Baculoviruses;base;Biochemical;Capsid;Cell Culture Techniques;Cessation of life;Chemicals;Classification;Clinical;Clinical Research;commercialization;Communicable Diseases;cost;cost effective;COVID-19 outbreak;data quality;Dedications;design;Detection;detection method;detection sensitivity;detector;Diagnostic;diagnostic strategy;Disease;disorder control;DNA;DNA Primers;DNA sequencing;emerging pathogen;Environment;Enzyme-Linked Immunosorbent Assay;Equipment;experience;fungus;Genus staphylococcus;Goals;Growth;Height;high volume manufacturing;Image;Imaging technology;improved;Infection;Infectious Agent;innovation;Institution;instrument;interest;Label;Laboratory Research;Lasers;Lateral;Lipids;Liquid substance;low and middle-income countries;Marketing;Measurement;Measures;mechanical properties;Medical;Membrane Proteins;Methods;microorganism;Microscopy;Molecular;molecular diagnostics;Morphology;nano;nanomechanics;nanoscale;Nanoscopy;near field microscopy;Noise;novel;novel strategies;operation;Optics;Organism;Outcome;Pathogenicity;Patients;Phase;photonics;Photons;Physiologic pulse;Positioning Attribute;premature;Prevention;Principal Component Analysis;Property;Proteins;prototype;Raman Spectrum Analysis;Rapid diagnostics;Research;Resolution;RNA;Sampling;Scanning;Scanning Probe Microscopes;Scanning Probe Microscopy;Science;Semiconductors;Signal Transduction;silicon nitride;single molecule;Small Business Innovation Research Grant;Spectrum Analysis;Speed;Structure;success;Surface;Technology;Testing;Time;Tobacco Mosaic Virus;tool;transcriptome sequencing;two-photon;United States National Institutes of Health;Variant;Viral;viral detection;Virion;Virus;virus identification;Visualization

PROJECT_TITLE: Novel Optical Scanning Probe Microscope for Biomedical Chemical Imaging with Ultra-High Spatial Resolution and Chemical Sensitivity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-S (12)]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Biomedical Imaging;Brain Disorders;Cancer;Cardiovascular;Cerebrovascular;Clinical Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Lung;Lung Cancer;Osteoporosis;Prevention;Stroke

ORG_CITY: TORRANCE

ORG_NAME: HEARTLUNG CORPORATION

PHR: Project Narrative AutoChamber™ is an AI-enabled opportunistic screening software tool that runs on any chest CT scan and detects asymptomatic patients who are high risk for future atrial fibrillation, stroke, and heart failure based on the volume of cardiac chambers and left ventricular mass. FDA has recently granted AutoChamber™ a Medical Device Breakthrough Designation due to its innovative and promising potential for early detection of irreversibly debilitating conditions such as heart failure and stroke. By analyzing existing and over 10 million new chest CT scans per year (US alone), AutoChamber has significant potential to save lives and healthcare dollars.

PI_NAMEs: NAGHAVI, MORTEZA  (contact)

PROGRAM_OFFICER_NAME: FARAHANI, KEYVAN

PROJECT_TERMS: Accidents;Accounting;Achievement;Address;Adoption;Age;Applications Grants;Atrial Fibrillation;Benchmarking;Bone Density;Breakthrough device;Budgets;Calcium;Cardiac;cardiac magnetic resonance imaging;Cardiac Volume;Cardiomegaly;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;chest computed tomography;Cohort Studies;Collaborations;commercialization;comparative;Consumption;contrast enhanced;coronary artery calcium;coronary calcium scoring;Coronary heart disease;cost;Data;Databases;deep learning;design;Detection;Devices;Diagnosis;Diagnostic;Early Diagnosis;Echocardiography;Electrocardiogram;Equation;Evaluation;Event;Eye;follow-up;Fostering;Framingham Heart Study;Funding;Future;Glean;Grant;Greenland;Health Care Costs;Healthcare;Heart failure;heart failure with reduced ejection fraction;heart imaging;high risk;high risk population;Hospitalization;Hospitals;Human;Individual;innovation;Institution;Investigation;Journals;Left;Left atrial structure;Left Ventricular Dysfunction;Left Ventricular Hypertrophy;Left Ventricular Mass;Left ventricular structure;Legal patent;Letters;Licensing;Life;lung cancer screening;Magnetic Resonance Imaging;Manuscripts;Marketing;Measurement;Measures;Medical;Medical Device;Medicine;Methods;Mission;Multi-Ethnic Study of Atherosclerosis;New England;Osteoporosis;Patients;Performance;Persons;Physicians;Pneumonia;Population;Positioning Attribute;preservation;Prevention;pro-brain natriuretic peptide (1-76);Procedures;prospective;Prospective Studies;Prospective, cohort study;repository;Research;Research Personnel;Right atrial structure;Right ventricular structure;Risk;Risk Assessment;Roentgen Rays;Running;Scanning;screening;Secure;Small Business Innovation Research Grant;Software Tools;standard of care;Stroke;success;Technology;Testing;Thick;tool;Training;United States;United States National Institutes of Health;Ventricular;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: AutoChamber: an FDA-Designated Breakthrough AI Add-on to Coronary Artery Calcium and Lung Cancer Screening CT Scans to Flag Patients at High Risk of Atrial Fibrillation, Stroke and Heart Failure


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: PROJECT NARRATIVE The eukaryotic genome is extensively complexed with proteins and RNAs to form chromatin. A variety of chem- ical modifications of DNA-binding histone proteins play a critical role in controlling chromatin structure, which in turn regulates a diverse set of biological processes implicated in human health and disease. This project will address the critical gap in essential biochemical tools and accessible experimental platforms that has hindered research on understudied modifications of histone proteins and enzymes that write them.

PI_NAMEs: KEUNG, ALBERT ;RAO, BALAJI M (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acetylation;acyl group;Address;Adopted;Affinity;Amino Acids;Antibodies;Arginine;Binding;Binding Proteins;Biochemical;biochemical tools;Biochemistry;Biological;Biological Assay;Biological Process;Biology;Biosensor;Bypass;cell behavior;cell growth regulation;Cell Physiology;Chemicals;ChIP-seq;Chromatin;Chromatin Structure;combinatorial;Complex;Cost Effectiveness Analysis;cost efficient;Disease;DNA;DNA Binding;DNA Modification Process;Dopamine;Engineering;Enzymes;Epigenetic Process;epigenetic silencing;Eukaryota;Gene Expression;Gene Expression Regulation;gene repression;Gene Silencing;Generations;Genetic Transcription;Genome;genome-wide;Genomic DNA;Glutamine;Goals;Health;Heart;Heritability;histone acetyltransferase;Histone Code;histone modification;histone-binding proteins;Histones;Human;live cell imaging;Lysine;Measurement;Mediating;Methylation;Modification;monoamine;Neurotransmitters;next generation;open source;Pattern;Play;Post-Translational Protein Processing;preference;Protein Engineering;Proteins;Quality Control;Reader;Reagent;Recombinant Proteins;Regulation;Research;Research Personnel;RNA;Role;Serotonin;Set protein;Site;Specificity;Structure;Surface;System;tool;Transcriptional Regulation;virtual;Work;Writing;Yeasts

PROJECT_TITLE: Scalable platforms for understudied histone modifications and modifiers

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Unintentional Childhood Injury

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: This project will conduct the first randomized controlled trial since 1983 to evaluate pre -licensure driver training on crash risk outcomes. It will determine whether behind-the-wheel and online training for hazard detection/response and attention maintenance confers additional protection over Graduated Driving Licensing (GDL) restrictions alone as measured by smartphone app - monitored driving. The study will enroll 1000 adolescents ages 16-18 in Pennsylvania, a state with GDL that does not require driver training.

PI_NAMEs: ROMER, DANIEL ;WINSTON, FLAURA K (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: 18 year old;Address;Adolescent;Age;age effect;age related;Area;arm;Attention;Automobile Driving;California;Caring;Cause of Death;Cellular Phone;Certification;Clinic;clinical practice;Cognitive;cognitive skill;Degree requirements;design;Detection;Development;driving behavior;driving performance;driving skills;Education;Educational Intervention;Effectiveness;Enrollment;Esthesia;experience;Future;Goals;hazard;Hour;improved;Impulsivity;Injury;Intervention;Laws;Licensing;Licensure;Maintenance;male;Measurement;Measures;Medical;Modernization;Monitor;Neurocognitive;Neuropsychology;Ohio;online delivery;Outcome;Participant;Pennsylvania;Performance;Personality;Personality Traits;Phase;Philadelphia;Placebos;point of care;Policies;Preparation;preservation;Randomized, Controlled Trials;Recommendation;recruit;Research;Research Design;Resistance;response;Risk;Risk Behaviors;Risk Factors;risky driving;Role;Rural;Safety;Sampling;Short-Term Memory;Site;skill acquisition;skills;skills training;smartphone application;suburb;sustained attention;Testing;Time;Training;Training and Education;treatment as usual;Vehicle crash;virtual;Young driver

PROJECT_TITLE: A Contemporary Look at Driver Training and Its Role In Reducing Crash Risk in Novice Adolescent Drivers.

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: CAMBRIDGE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative Transcriptional elongation of all class II genes is a highly regulated process within cells. The investigation of 7SK snRNP complexes proposed in this study will elucidate key structure-based mechanisms involved in transcriptional elongation of both cellular and HIV genes.

PI_NAMEs: D'SOUZA, VICTORIA MANUEL (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Adaptor Signaling Protein;Binding;Biological Process;Biology;biophysical tools;Calorimetry;Cancer Biology;Cell Cycle Regulation;Cell Nucleus;Cells;cellular targeting;Complex;Cryoelectron Microscopy;Disease;Elongation Factor;Entropy;Environment;Finland;Genes;Genetic Transcription;Heart Hypertrophy;Heterogeneity;HIV;HIV Genome;Human;Individual;insight;Invertebrates;Investigation;leukemia;Life Cycle Stages;Malignant Breast Neoplasm;Mediating;Messenger RNA;Methylation;MHC Class II Genes;Modification;Molecular;Molecular Conformation;negative elongation factor;Nuclear Magnetic Resonance;Outcome;Pharmacotherapy;Phase;Play;Process;Productivity;Proteins;reconstruction;Regulation;Repression;Resources;RNA;RNA Polymerase II;Site;Small Nuclear Ribonucleoproteins;Small Nuclear RNA;stem;Structure;System;tat Protein;Titrations;Transcript;Transcription Elongation;transcription factor;Transcriptional Elongation Factors;Transcriptional Regulation;Vertebrates;Viral;Virus

PROJECT_TITLE: Structural understanding of 7SK-snRNP mediated transcriptional regulation

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Gene Therapy;Genetics;Human Genome;Immunotherapy

ORG_CITY: LOS ANGELES

ORG_NAME: PARTILLION BIOSCIENCE CORPORATION

PHR: NARRATIVE Chimeric antigen receptor (CAR) cell therapies are a novel class of therapeutics that can fundamentally alter the fight against cancer. Unfortunately, high costs associated with development and manufacturing of these therapies remain as barriers to widespread adoption. With the funds received from this grant, Partillion will address the inaccessibility of these medications by introducing novel technologies to make the development of these therapeutics faster and more efficient, promoting access to life saving therapies to all.

PI_NAMEs: DE RUTTE, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Acceleration;Adoption;Affinity;Antigen Presentation;Antigen Targeting;Antigens;Area;base;Binding;Biological;Biological Assay;cancer immunotherapy;CAR T cell therapy;CD19 Antigens;CD19 gene;cell killing;Cell Physiology;Cell secretion;Cell Separation;Cell Therapy;Cells;cellular transduction;chimeric antigen receptor;chimeric antigen receptor T cells;Colon Carcinoma;cost;cytokine;design;Development;Effector Cell;engineered T cells;Engineering;Environment;Equipment;Event;exhaustion;experimental study;extracellular;fighting;fluorescence activated cell sorter device;Formulation;Foundations;functional improvement;Funding;Gene Targeting;gene therapy;Generations;Grant;Hematologic Neoplasms;Hydrogels;immunoengineering;In Vitro;in vivo;Individual;instrument;Jurkat Cells;Libraries;Life;Ligands;Link;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;manufacture;Measures;Medicine;Molecular;multiple omics;Natural Killer Cells;new technology;next generation;novel;novel strategies;Outcome;particle;Pathway Analysis;Pharmaceutical Preparations;physical property;population based;Price;Procedures;Production;Property;Protein Secretion;Raji Cell;receptor;response;screening;Signal Transduction;single cell sequencing;Solid Neoplasm;Sorting;Structure;success;System;T-Cell Receptor;T-Lymphocyte;Technology;Therapeutic;therapeutic development;timeline;Tissue Engineering;tool;Transcript;transcriptome;transcriptomics;Transmembrane Domain;tumor microenvironment;tumor-immune system interactions;Variant

PROJECT_TITLE: Hydrogel microparticle technology for high-throughout screening of chimeric antigen receptor-T cells based on single cell effector function


ADMINISTERING_IC: AI

ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Mental Health;Physical Activity;Prevention;Vaccine Related

ORG_CITY: AMES

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE  The objective of this research is to determine the extent to which a single session of exercise that takes place after receiving a SARS-CoV-2 mRNA-based vaccine (Pfizer or Moderna) may enhance immune response to the vaccine. A second goal is to determine how psychological stress impacts vaccine response. Finally, the potential pathways by which exercise influences immune response will be identified.

PI_NAMEs: KOHUT, MARIAN L (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Acute;Address;Adjuvant;Antibodies;Antibody Response;Antigens;Behavior Therapy;bench-to-bedside translation;Body Weight;Buffers;CD8-Positive T-Lymphocytes;cell mediated immune response;Cellular Metabolic Process;Chronic;Complex;COVID-19;COVID-19 vaccination;COVID-19 vaccine;Critical Pathways;cytokine;Data;Dendritic Cells;Dose;Elderly;Exercise;Exhibits;field study;Formulation;Gene Expression;Glucocorticoids;Goals;Health Status;Helper-Inducer T-Lymphocyte;human old age (65+);Immune;immune activation;Immune response;Immunity;Immunization;immunogenicity;Immunoglobulin G;Immunologic Memory;Impairment;implementation barriers;improved;Individual;insight;Integration Host Factors;Knowledge;Learning;Literature;Maps;Measures;Mental Health;Messenger RNA;Metabolic;metabolic profile;Metabolism;metabolomics;Modeling;Moderna COVID-19 vaccine;neutralizing antibody;Nonpharmacologic Therapy;novel;Obesity;Outcome Measure;pathogen;Pathway interactions;Patient Self-Report;perceived stress;Pfizer-BioNTech COVID-19 vaccine;physical conditioning;Physical Exercise;Population;Positioning Attribute;Protocols documentation;Psychological Stress;Psychosocial Stress;Public Health;Publications;Raman Spectrum Analysis;receptor binding;Reporting;Reproducibility;Research;response;RNA vaccine;Serum;sex;Shapes;side effect;Standardization;Stress;Surveys;T cell response;T memory cell;T-Lymphocyte;Time;transcriptome sequencing;transcriptomics;translational applications;translational impact;Underserved Population;Vaccination;vaccine development;vaccine efficacy;vaccine formulation;vaccine immunogenicity;vaccine response;Vaccines

PROJECT_TITLE: Adjuvant effect of physical exercise on immune response to COVID-19 vaccination and interactions with stress

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Estrogen;Genetics;Human Genome;Menopause;Osteoporosis;Prevention;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative Our clinical trial will interrogate the potential for bazedoxifene plus conjugated estrogen (commercially available as Duavee®) to modulate breast tissue-based risk biomarkers. A successful trial will not only inform the development of larger, cancer incidence-based trials, but will also provide assurance to women at high risk for development of breast cancer that an effective agent approved for relief of vasomotor symptoms and prevention of osteoporosis will not increase their risk for breast cancer.

PI_NAMEs: FABIAN, CAROL J. (contact)

PROGRAM_OFFICER_NAME: SAUTER, EDWARD RICHARD

PROJECT_TERMS: Age;Agonist;Agreement;angiogenesis;automated assessment;Benign;Biological Availability;Biological Markers;Blinded;Blood;Body fat;bone;Breast;Breast Cancer Risk Factor;Chemoprevention;Clinical Trials;Cognition;Complex;Computer software;Conjugated Estrogens;cytokine;Development;digital;Digital Mammography;Eligibility Determination;Encapsulated;Endocrine;Enrollment;Estrogen Antagonists;Estrogen Receptors;Estrogens;Fasting;FDA approved;Fine needle aspiration biopsy;Fright;Gene Expression;Genes;High Risk Woman;Hormones;Hot flushes;IGFBP3 gene;immunocytochemistry;Incidence;Inflammation;Inflammatory;Institution;Insulin Resistance;Insulin-Like Growth Factor I;Intervention;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammography;Marketing;Measures;men;Messenger RNA;Motility;open label;Osteoporosis prevention;Outcome Assessment;Outcome Measure;Patient Outcomes Assessments;Perimenopause;Pharmaceutical Preparations;Phase;Phosphoproteins;Pilot Projects;Placebo Control;Placebos;Plasma;Postmenopause;predicting response;Premature Menopause;Prevention trial;primary endpoint;Progesterone;Progesterone Receptors;Proliferating;Property;Protein Array;Proteins;Quality of life;Randomized;receptor;response biomarker;Risk;Risk Reduction;Sample Size;secondary endpoint;Serum;Sex Hormone-Binding Globulin;side effect;Site;Testosterone;Tissue Banks;Tissues;TRANCE protein;transcriptome sequencing;tumor;Tumor necrosis factor receptor 11b;Uterus;vasomotor symptoms;Visceral fat;Woman

PROJECT_TITLE: Biomarker-Based Phase IIB Trial of (Bazedoxifene-Conjugated Estrogen) to Reduce Risk for Breast Cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Human Genome;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Maternal inflammation during pregnancy is a compelling target for developmental health research given its connection to a wide range of prenatal exposures, such as stress, poverty, and trauma. Maternal inflammation during pregnancy can adversely affect offspring neurodevelopment in early childhood, but mechanisms are not well understood. This proposal focuses on epigenetic age, a biomarker of accelerated biological aging, as an underlying mechanism through which prenatal inflammation influences offspring neurocognition.

PI_NAMEs: SHIAU, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: 4 year old;accelerated epigenetic aging;Acceleration;Adult;Adverse effects;adverse outcome;Affect;Age;age acceleration;aging clocks;Animals;Anxiety;bead chip;biobank;Biological Markers;Biological Specimen Banks;Biometry;Birth;Blood;Body mass index;C-reactive protein;Child;Childhood;Chronology;Clinical;clinical epidemiology;clinically relevant;Cognitive;Cognitive Science;cohort;Collection;cost effective;cost efficient;critical developmental period;cytokine;Data;Development;DNA Methylation;early childhood;Environment;epidemiology study;Epigenetic age;epigenetic aging;epigenetic clock;Epigenetic Process;epigenomics;executive function;Exposure to;fetal;Fetus;First Pregnancy Trimester;Future;genomic biomarker;Gestational Age;Goals;Health;human old age (65+);IL8 gene;Immunology;Impaired cognition;improved;in utero;infancy;Infant;Infant Development;Inflammation;Inflammatory;Infrastructure;innovation;insight;Intelligence;Interdisciplinary Study;Interferon Type II;Interleukin-1 beta;Interleukin-2;Interleukin-6;Intervention;Knowledge;life history;life span;Link;Longitudinal Studies;Maternal Age;Maternal and Child Health;Measures;Mediating;Methylation;Molecular;Morbidity - disease rate;Neurocognition;Neurocognitive;neurodevelopment;Neurodevelopmental Disorder;novel;Obesity;offspring;older adult;Outcome;Perinatal Epidemiology;Phenotype;Poverty;Pregnancy;Pregnancy Trimesters;Pregnant Women;prenatal;prenatal exposure;prepregnancy;Process;psychologic;Reporting;Research;Risk;sex;Signal Transduction;sociodemographics;Specimen;Stress;Swab;systemic inflammatory response;Testing;TNF gene;Translating;Trauma;United States National Institutes of Health;Visit;Wechsler Scales;Work;young adult

PROJECT_TITLE: Maternal inflammation in relation to offspring epigenetic aging and neurodevelopment

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: Project Narrative This proposed research will explore the role of the Affordable Care Act Marketplaces in providing health insurance for pregnant people, facilitating access to timely, high-quality prenatal care, and improving maternal and infant health outcomes. We will take advantage of a natural experiment created by state variation in Marketplace eligibility rules to examine the impact of a policy to include pregnancy as a Marketplace special enrollment period qualifying event; this policy has been enacted in six U.S. states and is being considered in multiple other states and at the federal level. The results of this project will provide critical and timely information for policy-makers to ensure that Marketplace coverage is (i) accessible for pregnant people without other insurance coverage options, and (ii) effective in improving access to prenatal care and, ultimately, child and maternal health outcomes.

PI_NAMEs: GARABEDIAN, LAURA FADEN (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: adverse outcome;Affordable Care Act;Anatomy;Birth;care systems;Caring;Censuses;Cessation of life;Characteristics;Child Health;Childbirth;Classification;Comprehensive Health Insurances;Data;design;Diagnosis;Eligibility Determination;Enrollment;Event;falls;Family;Gestational Diabetes;Guidelines;Health;Health Benefit;health care service utilization;Health Insurance;Health Services Accessibility;Healthcare;hospital readmission;Hospitalization;Household;Improve Access;improved;Individual;Infant;Infant Health;infant outcome;Insurance;Insurance Carriers;Insurance Coverage;insurance plan;Intervention;Job loss;Laws;Length of Stay;Life;Link;Low Birth Weight Infant;Marriage;Massachusetts;Maternal Health;Measures;Medicaid;member;Methods;Mothers;Natural experiment;Neighborhoods;New York;novel;Outcome;Perinatal;Persons;Policies;Policy Maker;Policy Making;postnatal period;Postpartum Depression;Pre-Eclampsia;Pregnancy;pregnant;Premature Birth;prenatal;Prenatal care;Qualifying;Quasi-experiment;Recommendation;Reporting;Research;Role;socioeconomics;Source;Special Event;Surveys;Time;Ultrasonography;Uninsured;Vaccines;Variant

PROJECT_TITLE: The Impact of Including Pregnancy as a Qualifying Life Event for Marketplace Special Enrollment on Child and Maternal Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Neurosciences;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE As Cannabis use has doubled in the last 4 years, it is critical to better understand the behavioral impact of its primary intoxicating compound, ∆9-tetrahydrocannabinol (THC), in particular how it impairs spontaneous locomotion and how this relates to its abuse liability. Using a series of novel cutting-edge monitoring modalities, including an innovative sensor of the endocannabinoid, 2-arachidonoylglycerol (2-AG), we discovered that transient increase in 2-AG levels in the prelimbic cortex of the mouse brain correlates with initiation of locomotion after periods of immobility, and that this transient increase in 2-AG levels is potentiated by THC treatment. The goal of this exploratory R21 grant is to uncover the brain circuit mechanisms by which changes in 2-AG levels in the PFC are involved in initiation of locomotion and how THC modulate this mechanism in mice.

PI_NAMEs: STELLA, NEPHI  (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: 2-arachidonylglycerol;abuse liability;Address;Affective;Age;Agonist;Applications Grants;Behavior;Behavioral;behavioral impairment;Biological;Biosensing Techniques;Brain;Calcium;cannabimimetics;Cannabis;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;CNR1 gene;Coupled;Data;differential expression;Disinhibition;Dose;Electrophysiology (science);endocannabinoid signaling;Endocannabinoids;Equilibrium;Event;excitatory neuron;executive function;Fiber;Foundations;Frequencies;gamma-Aminobutyric Acid;Genetic;Glutamates;Goals;Grant;hippocampal pyramidal neuron;Human;Immobilization;Impairment;In Situ Hybridization;in vivo;Individual;inhibitor;inhibitory neuron;innovation;Interneurons;Intoxication;Locomotion;Mammals;Maps;marijuana use;Measures;Mediating;Modality;Modernization;Modification;Molecular;Monitor;Motor Activity;motor impairment;mRNA Expression;Mus;Nature;Neocortex;neocortical;neural circuit;Neurons;novel;optogenetics;Outcome;pharmacologic;Photometry;Physiological;Prefrontal Cortex;Regulation;Resolution;response;Role;Running;sensor;Series;Signal Transduction;Slice;Synaptic Transmission;System;Techniques;Technology;Testing;Tetrahydrocannabinol;THC exposure;Time;Viral

PROJECT_TITLE: Role of CB1R expressed in the prefrontal cortex in the control of locomotion

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Teenage Pregnancy;Women's Health Research

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE Though adolescent mothers are at higher HIV risk than non-parenting peers in sub-Saharan Africa, some adolescent mothers fare worse than others. Examining spatial variability in HIV risk and differences in adolescent mother’s relationship types may be key to understanding their HIV risk. Further, investigating the impact of multilevel factors on HIV risk and unprotected sex will inform tailored HIV prevention interventions and policies for this vulnerable population.

PI_NAMEs: GEBREKRISTOS, LUWAM T (contact)

PROGRAM_OFFICER_NAME: LEE, SONIA S

PROJECT_TERMS: 19 year old;Address;Adolescent;adolescent health;Adolescent HIV risk;Adult;Africa South of the Sahara;aged;AIDS prevention;Applications Grants;Area;Behavioral;career;Characteristics;Communication;cost efficient;Country;Data;Data Analyses;design;Education;Epidemic;Epidemiologist;Fellowship;Female Adolescents;Funding;Future;Gender;Geography;girls;Goals;health care availability;health disparity;health equity;Health Priorities;Heterogeneity;high risk;HIV;HIV diagnosis;HIV Infections;HIV risk;HIV Seronegativity;HIV-infected adolescents;Household;Individual;Inequity;Institution;Intervention;Knowledge;Laboratories;Laboratory Diagnosis;Lead;Link;Machine Learning;Maps;marginalization;Masks;Measures;Mediation;Mentorship;Methodology;Methods;Modeling;motherhood;Mothers;multidisciplinary;National Institute of Child Health and Human Development;Participant;peer;Persons;Policies;Population;population based;Populations at Risk;Poverty;Prevalence;Prevention Research;Prevention strategy;preventive intervention;programs;Public Health Schools;Research;research data dissemination;Research Priority;Resources;Risk;Risk Factors;Safe Sex;Sample Size;Sampling;Sex Behavior;sexual relationship;skills;social;social epidemiology;Source;spatial integration;structural determinants;Subgroup;Techniques;teenage mother;Training;transactional sex;transmission process;Typology;United States National Institutes of Health;Universities;Unsafe Sex;Urbanicity;Urbanization;Vulnerable Populations;Writing;young woman

PROJECT_TITLE: Integrating spatial and non-spatial data to examine multilevel drivers of HIV risk among adolescent mothers in sub-Saharan Africa


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Huntington's Disease;Lymphatic Research;Neurodegenerative;Neurosciences;Prevention;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Huntington’s disease (HD) is a fatal neurodegenerative disorder and has no cure or disease-modifying treatment. Most approaches are currently targeted at manifest HD when clinical outcomes can be used to evaluate the effectiveness. The objective of this project is to identify early brain functional changes that rapidly respond to treatment to serve as sensitive biomarkers in HD clinical trials, particularly in the premanifest period.

PI_NAMEs: DUAN, WENZHEN  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Acceleration;Affect;Age;Atrophic;Basal Ganglia;Behavior assessment;Behavioral;Biological Markers;Biology;biomarker identification;Blood;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier permeabilization;Brain;Brain Diseases;brain metabolism;Brain region;brain volume;cerebral atrophy;cerebral blood volume;cerebrovascular;cerebrovascular reactivity;Cerebrum;Clinical;clinical diagnosis;Clinical Trials;Code;Corpus striatum structure;Coupled;CRISPR/Cas technology;Data;detection method;Disease;Disease Progression;early detection biomarkers;Early identification;effectiveness evaluation;Elements;Event;Functional Magnetic Resonance Imaging;gain of function;gene therapy;Genes;glymphatic dysfunction;glymphatic function;glymphatic system;Goals;Human;Huntington Disease;Huntington gene;Impairment;indexing;Inherited;Knock-in Mouse;Length;lymph flow;Lymphatic;lymphatic drainage;lymphatic vessel;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Mediating;Metabolic;metabolic rate;Metabolism;Monitor;Motor;motor symptom;mouse model;Movement Disorders;multimodality;Mus;mutant;Nature;Neurodegenerative Disorders;neuropathology;neurovascular;neurovascular unit;novel;Outcome;Outcome Measure;Oxygen;Pathogenicity;Patients;Phase;Photic Stimulation;preclinical study;prevent;protein aggregation;Recording of previous events;Relaxation;Reporting;response;Signal Transduction;Symptoms;System;Techniques;Testing;Therapeutic;Time;treatment effect;Treatment Efficacy;Treatment Protocols;treatment response;wasting

PROJECT_TITLE: Advanced MRI biomarkers in HD mouse models translatable to humans: nature history and response to therapeutics

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project narrative In this infrastructure proposal, we propose to genotype the Understanding America Study (UAS), a nationally representative Internet panel that longitudinally tracks a sample of about 10,000 (growing to at least 20,000 by 2026) adults in the U.S. We will create a large number of “polygenic scores” (PGSs), indexes that provide an aggregated measure of the genetic influences towards a specific trait. By making publicly available a large number of PGSs for ADRD and cognitive decline, in combination with associated protective and detrimental health, environmental, and behavioral factors, and through our research, we aim to stimulate creative social- science research in ADRD, cognitive impairment, and cognitive decline that utilizes the unique capabilities of the UAS.

PI_NAMEs: FAUL, JESSICA ;GALAMA, TITUS JOHANNES (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Address;Adult;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;apolipoprotein E-4;Area;Behavior;Behavioral;behavioral response;California;cardiovascular risk factor;Caregivers;Cessation of life;Cognition;Cognitive;cognitive function;Collection;Communities;Complex;Computers;COVID-19 pandemic;Creativeness;Data;Data Collection;data storage site;Dementia;dementia risk;Diabetes Mellitus;Diet;DNA;Economics;Education;Educational workshop;Employment;Environment;Event;Family;field survey;Frequencies;Genetic;Genetic Predisposition to Disease;Genetic Risk;Genetic study;genetic variant;Genome;genome wide association study;Genotype;Glean;Health;Hypertension;Impaired cognition;indexing;Individual;Infrastructure;innovation;Internet;Life;Measures;member;Monitor;Morbidity - disease rate;National Institute on Aging;Natural experiment;Neurobehavioral Manifestations;novel;Obesity;Occupations;operation;Outcome;Participant;Phenotype;phenotypic data;Physical activity;Physical environment;Policies;Policy Maker;Pollution;Populations at Risk;prevent;Probability;processing speed;protective factors;Publishing;Quasi-experiment;Recording of previous events;recruit;Research;Research Personnel;resilience;Respondent;response;Risk;Risk Factors;risk mitigation;Role;Salivary;Sampling;Sleep;Smoking;social;Social Environment;social science research;Social Sciences;Societies;Source;Standardization;Surveys;Tablets;trait;Unemployment;Universities;Variant;wearable device;Weight

PROJECT_TITLE: Genotyping the Understanding America Study to generate novel opportunities for research on cognitive functioning and dementia

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


ADMINISTERING_IC: FD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative: As a vibrant research community, OHDSI aims to develop the methods and open-source analytics for large- scale research and lay the foundation for scientific best practices in observational health research. The annual symposium offers a forum for OHDSI collaborators to share our vision and align our goals with the needs of the broader healthcare community, ultimately enhancing healthcare decision-making and improving outcomes for patients.

PI_NAMEs: HRIPCSAK, GEORGE M (contact)

PROGRAM_OFFICER_NAME: GONZALEZ, MADILYN

PROJECT_TITLE: Annual OHDSI Symposium


NIH_SPENDING_CATS: Aging;Cancer;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: OAKLAND

ORG_NAME: PUBLIC HEALTH INSTITUTE

PHR: This research will have sustained impact by showing, in a race-specific manner, whether mitochondrial metabolic pathways vary with lethal and early-onset prostate cancer risk decades before cancer onset, whether these changes associate with concurrent environmental exposures, and whether multi-generational associations occur between metabolic or environmental exposures and early-onset prostate cancer. The results will help define men who will benefit from intense screening and accelerate prevention with direct, critical relevance to populations of African Americans who have unacceptably high risk of early onset and lethal prostate cancer.

PI_NAMEs: COHN, BARBARA A (contact);JONES, DEAN PAUL

PROGRAM_OFFICER_NAME: PARNES, HOWARD L

PROJECT_TERMS: Acceleration;Address;African American;African American population;Age;Alcohol consumption;Bioenergetics;Birth;Blood specimen;cancer diagnosis;cancer health disparity;carcinogenesis;Cessation of life;chemical association;Child Development;Child Health;cigarette smoking;Cohort Studies;County;Daughter;design;Development;Diagnostic;Disparity;early onset;Endocrine disruption;Endocrine Disruptors;environmental chemical;Environmental Exposure;Environmental Risk Factor;Fathers;follow-up;Foundations;Generations;health disparity;high risk;Income;innovation;Life;Life Cycle Stages;Link;male;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;men;Metabolic;Metabolic Pathway;metabolome;metabolomics;Mitochondria;mortality;Mothers;Occupations;Onset of illness;Outcome;Pathway interactions;Pregnancy;prenatal;Prevention;Prevention strategy;programs;prospective;prostate cancer risk;protective pathway;Race;racial disparity;repository;Research;Resolution;Risk;Sampling;screening;Serum;sex;Son;study population;Testing;Time;young adult;young man

PROJECT_TITLE: Discriminatory Mechanisms in Early-Onset and Lethal Prostate Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-J(55)R]


NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE Identifying specific, modifiable processes related to health inequities is necessary for prevention science and public policy efforts to curb the troubling new premature midlife mortality trends. The complementary set of proposed aims will develop a new data source for samples of key racial/ethnic populations in two regions (the Appalachia and the Black Belt regions of North Carolina) that will permit identification of these linkages and allow comparisons with more urban populations to improve our understanding of the current midlife mortality crisis in the U.S.

PI_NAMEs: CAGNEY, KATHLEEN A;COPELAND, WILLIAM  (contact);DUKE, NAOMI N;HOTZ, VINCENT JOSEPH;LANSFORD, JENNIFER E

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: addiction;Adult;adverse childhood events;Affect;African American;African American population;Age;Aging;Alcohol abuse;American Indians;Appalachian Region;Area;Attention;Attitude;base;Behavioral;Black Populations;Black race;Blood;Blood Pressure;Body System;Cardiometabolic Disease;Cause of Death;Censuses;Characteristics;Cherokee Indian;Cognition;Collaborations;Collection;Communities;computerized;Consent;County;Coupled;Data;Data Collection;data harmonization;Data Set;Data Sources;Databases;Death Rate;Diabetes Mellitus;Disease;Disparity;Ecological momentary assessment;Economics;Education;Educational workshop;Emotional;Employment;Equation;ethnic difference;Ethnic Origin;Ethnic Population;executive function;FAIR principles;Frequencies;Funding;Gender;Geography;Goals;Health;health assessment;health determinants;health disparity populations;health inequalities;Health Status;Healthcare;Height;Home;Hypertension;improved;Income;Individual;Knowledge;Life;Life Expectancy;Measurement;Measures;Memory;Mental Depression;Methods;middle age;Modeling;Monitor;Moods;mortality;Movement;multilevel analysis;National Archive;National Longitudinal Survey of Adolescent to Adult Health;Native Americans;Neurocognitive;North Carolina;Not Hispanic or Latino;Obesity;optimism;Outcome;Overdose;Participant;Persons;Pharmaceutical Preparations;Politics;Populations at Risk;premature;Premature Mortality;Prevention;Process;Protocols documentation;Public Policy;pulmonary function;Race;racial difference;racial population;recruit;regional difference;Religion;Research;resilience;resilience factor;Resources;Risk;Risk Behaviors;Risk Factors;Role;Rural;rural America;Rural Appalachia;rural area;rural counties;Rural Health;Sampling;Science Policy;Scoring Method;Smoking;social;Social Environment;Social Functioning;Social isolation;social situation;Social support;socioeconomics;Spirituality;Spottings;Statistical Methods;Statistical Models;Suicide;Surveys;Testing;Time;trend;Unemployment;United States National Institutes of Health;Urban Population;Walking;Weight;Work

PROJECT_TITLE: Mid-Life Health Inequalities in the Rural South: Risk and Resilience