NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Human Genome;Patient Safety;Precision Medicine;Prevention

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Clopidogrel is among the most widely prescribed medications to prevent adverse cardiovascular outcomes in patients with acute coronary syndrome and/or undergoing percutaneous coronary intervention. Given the wide variability in platelet aggregation and clinical outcomes in response to clopidogrel therapy, it is critical to identify the metabolic and genetic factors that cause altered drug efficacy and to better predict those who are more susceptible to altered clopidogrel response. The proposed research will provide insights into the cause(s) of clopidogrel failure and will ultimately help physicians prescribe the most effective antiplatelet therapy based on metabolic and genetic background.

PI_NAMEs: LEWIS, JOSHUA PATRICK (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: acute coronary syndrome;Adoption;Adverse reactions;Area;Aspirin;Biological Markers;Blood;Blood Platelets;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cessation of life;Clinical;clinical investigation;Clinical Research;clopidogrel;cohort;Data;design;Development;Disease;drug action;drug efficacy;Drug Exposure;Drug Kinetics;Drug Prescriptions;Effectiveness;Event;experience;Failure;Genetic;genetic approach;Genetic Markers;genetic predictors;genetic variant;genome wide association study;genome-wide;Genomics;Genotype;Hemorrhage;inhibitor;insight;instrument;inter-individual variation;International;Intervention;intervention participants;Intervention Studies;Investigation;Ischemia;Measures;Mendelian randomization;Metabolic;Metabolism;metabolomics;Methodology;Methods;multiple data sources;multiple omics;Myocardial Infarction;non-genetic;novel;novel marker;novel therapeutics;Other Genetics;Outcome;Parents;Participant;Pathologic;Pathway Analysis;Pathway interactions;Patients;percutaneous coronary intervention;personalized care;personalized medicine;Pharmaceutical Preparations;Pharmacogenomics;Pharmacometabolomics;Phenotype;phenotypic data;Physicians;Platelet aggregation;platelet phenotype;polygenic risk score;precision medicine;predicting response;predictive marker;Predisposition;prevent;Prodrugs;Publishing;receptor;recruit;Recurrence;Research;response;Risk;Risk Assessment;Risk Factors;risk prediction;Risk Reduction;Secondary Prevention;side effect;Signal Transduction;Stroke;Testing;Therapeutic Agents;thrombotic;Time;treatment planning;treatment strategy;United States National Institutes of Health;Variant

PROJECT_TITLE: Integration of Pharmacogenomics and Metabolomics in the Study of Antiplatelet Efficacy

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ADMINISTERING_IC: LM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Disability Research;Social Determinants of Health

ORG_CITY: NOTRE DAME

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project Narrative  This project documents the role of medicine and physicians in barring disabled people from many legal, political, and social rights, such as marriage and voting, in the decades after our nation’s founding. Health professionals, public health officials, and historians of medicine must recognize medicine’s historical role in supporting and defending structural ableism. Such an awareness provides crucial context for present-day work for greater access and equality in medicine and American society more broadly.

PI_NAMEs: DAEN, LAUREL  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TITLE: Examining the Effects of Disability on Citizenship in the Early United States, 1775-1840

STUDY_SECTION_NAME: Special Emphasis Panel[ZLM1 ZH-P (01)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: Vision impairment and blindness due to optic nerve injury from trauma, optic nerve stroke, and glaucoma are serious clinical problems that have dramatic consequences on the Veteran’s quality of life. Ocular injuries and disease characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy result in the reduction or loss of vision. This Merit Review will test the hypothesis that limiting a calcium-permeable (CP)- AMPA glutamate receptor mediated increase of intracellular Ca2 following optic nerve injury or during early elevated ocular hypertension maintains or restores RGC function and structure. Studies will utilize pharmacological and genetic approaches that suppress CP-AMPAR activity to assess RGC dendritic structure, synaptic receptors, light responsiveness, long-term cell survival and visuomotor behavior. Foundational findings will set the stage for the development of novel therapeutic strategies and interventions targeted to reduce retinal cell and axon degeneration. These studies are consistent with the health-related goals of the VA.

PI_NAMEs: BRECHA, NICHOLAS C. (contact)

PROJECT_TERMS: Acute;Address;AMPA Receptors;antagonist;Anterior Ischemic Optic Neuropathy;Apoptosis;Area;Atrophic;axonal degeneration;Behavior;Biological Models;Blindness;Calcium;Cell Death;cell injury;Cell Physiology;Cell Survival;cell type;Cells;Cellular Structures;Chronic;Clinical;Craniocerebral Trauma;Cytoprotection;Dendrites;Development;DRADA2b protein;Early Intervention;Enzymes;Event;Excitatory Synapse;extracellular;Eye diseases;Eye Injuries;Foundations;Gene Family;gene therapy;genetic approach;Genetic Suppression;Glaucoma;glial activation;Glutamate Receptor;Goals;Health;Hour;injured;Injury;Intervention;Investigation;Light;Light Cell;Mediating;Modeling;Molecular;Morphology;Nerve Cell Survival;Nerve Crush;Nerve Degeneration;Nerve Fibers;nerve injury;nerve transection;neurochemistry;Neuronal Injury;novel strategies;novel therapeutic intervention;Ocular Hypertension;Optic Nerve;Optic Nerve Injuries;Pathologic;Permeability;pharmacologic;Physiologic Intraocular Pressure;Physiological;Play;preservation;prevent;Property;Quality of life;receptive field;receptor;receptor expression;Receptor Gene;Receptor Up-Regulation;receptor upregulation;Reporting;response;response to injury;Retina;retinal ganglion cell degeneration;Retinal Ganglion Cells;RNA Editing;Role;Scotoma;Source;Stroke;Structure;Synapses;Synaptic Receptors;Testing;Trauma;uptake;Veterans;Vision;visual dysfunction;Visual impairment;visual motor

PROJECT_TITLE: Suppression of elevated intracellular Ca2+ as an early intervention to prevent vision loss

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURF-H (01)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Congenital Structural Anomalies;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: This project takes a multidisciplinary approach involving live microscopy, genetics and computational sciences to address novel mechanisms that mediate cell movement and achieve tissue morphogenesis. The biological insights and the tools developed in this project will ultimately help us understand complex tissue formation in humans and birth defects.

PI_NAMEs: BAO, ZHIRONG  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: 3-Dimensional;Address;Adhesions;Algorithms;alpha-latrotoxin receptor;Antibodies;Appearance;Behavior;Biological;Biological Models;Biology;Caenorhabditis elegans;cell behavior;Cell division;Cell Lineage;cell motility;cell type;Cells;cellular imaging;Cessation of life;combinatorial;Complex;Computational Science;Computer software;Congenital Abnormality;Coupled;Data;data integration;data modalities;deep learning;deep neural network;design;Detection;Development;Developmental Process;directional cell;Electrons;Embryo;Embryonic Development;Engineering;experimental study;Feedback;Fluorescence;Fluorescence Microscopy;Formulation;G-Protein-Coupled Receptors;Genetic;Genomics;Graph;Hour;Human;Image;Image Analysis;image reconstruction;image registration;Imaging Device;improved;in vivo;Individual;insight;Intercalated Cell;interdisciplinary approach;Knowledge;Learning;learning algorithm;Measures;Mediating;Methods;Microscopy;Modality;model organism;Molecular;Morphogenesis;Motility;Names;neural network;novel;open source;Organ;Organism;Organoids;Pathway interactions;Pattern;planar cell polarity;Play;Proteins;Research;Research Personnel;Role;Scheme;single cell analysis;Stains;synergism;System;Technology;technology development;Tissues;tool;transcriptomics;Variant

PROJECT_TITLE: In vivio single-cell analysis of dynamic cell behaviors

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Drug Abuse (NIDA only);Foodborne Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

ORG_CITY: CHICAGO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE The proposed research on natural food-handling behavior in freely moving mice is relevant to public health, both for advancing fundamental neuroscience knowledge about mammalian behavior and brain function and because a wide spectrum of common disorders can impair these behaviors in humans. The proposed research is thus relevant to those aspects of the NIH mission aimed at improving health through understanding pathophysiological mechanisms in disorders causing disability.

PI_NAMEs: SHEPHERD, GORDON M (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: 3-Dimensional;Adolescent;analytical method;Animals;Attention;Behavior;behavior measurement;Behavioral;behavioral impairment;behavioral study;Body part;Brain;brain behavior;Breathing;comparative;Complex;computer framework;Computer Models;Computer software;Computing Methodologies;Consumption;Coupled;Data;data integration;design;Detection;Development;dexterity;disability;Disease;Electromyography;Elements;Ethology;Food;Food Analysis;food consumption;Food Handling;Forelimb;Foundations;Future;Goals;Hand;Hand functions;Head;Health;Human;improved;innovation;instrumentation;interdisciplinary approach;Investigation;Jaw;kinematics;Knowledge;Learning Skill;Link;Locomotion;Machine Learning;Mammals;Manuals;Measures;method development;Methods;Mission;Modality;model organism;Modeling;Motor;motor behavior;Movement;multimodality;Mus;Muscle;neural;neuromechanism;neurophysiology;Neurosciences;novel strategies;Olfactory Pathways;Oral cavity;Outcome;Physiological;Plants;Positioning Attribute;Primates;programs;prototype;Public Health;Research;Resolution;Respiration;respiratory;Respiratory System;Robotics;Rodent;Role;somatosensory;spatiotemporal;Speed;System;Theoretical model;tool;United States National Institutes of Health;Visual;Work

PROJECT_TITLE: Multimodal behavioral analysis of oromanual food-handling in freely moving animals

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SXC-N (O1)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Cancer;Brain Disorders;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Rare Diseases

ORG_CITY: RICHMOND

ORG_DEPT: NEUROLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Fear of cancer recurrence (FCR) is alarmingly high among patients with primary malignant brain tumors and their caregivers, yet psychological interventions targeting FCR have historically excluded both populations from investigation. This project aims to assess the feasibility and acceptability of recruitment strategies, target population, and appropriateness of a waitlist-control group for the delivery and evaluation of FearLess, a newly- developed, evidenced-informed, mindfulness-based, cognitive-existential, telehealth psychological intervention specifically designed to target FCR in neuro-oncology. This study builds upon our previous work, and results are vital to resolve information gaps regarding recruitment methodology, study population suitability, and control group feasibility prior to FearLess protocol finalization and large-scale intervention trials.

PI_NAMEs: BRAUN, SARAH ELLEN;LOUGHAN, ASHLEE RUTH (contact)

PROGRAM_OFFICER_NAME: ADAMS, LYNN S

PROJECT_TERMS: 2 arm randomized control trial;acceptability and feasibility;Address;Adherence;Affect;Anomia;Anxiety;arm;Auras;Behavior;Brain Neoplasms;Cancer Patient;cancer recurrence;Caregivers;Cognitive;Communities;Control Groups;coping;cost;curative treatments;daily functioning;design;Disease;Distress;Eligibility Determination;Enrollment;Ensure;Evaluation;Exclusion;experience;Family member;Feasibility Studies;follow-up;Fright;Future;Goals;Headache;Health Personnel;Impaired cognition;implementation intervention;inclusion criteria;Inequity;interest;Intervention;Intervention Trial;Investigation;Knowledge;Link;Malignant neoplasm of brain;Malignant Neoplasms;Manuals;Medical;Mental Depression;Mental Health;Methodology;Methods;mindfulness;Modality;Modeling;multimodality;neuro-oncology;Neurologic;Newly Diagnosed;novel;Oncology;Outcome Measure;Participant;Patients;Pattern;Phase;Physicians;pilot trial;Play;Population;post intervention;Procedures;Protocols documentation;psychologic;Randomized;Recommendation;recruit;Recurrence;Recurrent disease;Recurrent tumor;Resolution;response;Risk;Role;Sample Size;satisfaction;screening;social media;Source;Stratification;study population;Symptoms;Target Populations;telehealth;Testing;Therapeutic;therapy development;Time;treatment adherence;treatment group;tumor growth;tv watching;Uncertainty;Underserved Population;United States National Institutes of Health;Waiting Lists;Work

PROJECT_TITLE: Investigating Feasibility and Acceptability of the FearLess Protocol for Patients with Primary Malignant Brain Tumors and Their Caregivers

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-9 (O1)]


ADMINISTERING_IC: AG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Osteoporosis

ORG_CITY: KANSAS CITY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

ORG_STATE: MO

PHR: Public Health Relevance Statement Osteoporosis is an age-related disease characterized by low bone mass and leads to a compromised musculoskeletal structure and increased risk of fracture. Mechanical loading, in the form of exercise interventions, are known to result in enhanced bone formation. This project, using a diverse interdisciplinary team of researchers, investigates the role of mechanical strain and fluid shear stress on the osteocyte/dendrite membranes in activation of bone formation biological pathways and the changes associated with aging in both males and females.

PI_NAMEs: GANESH, THIAGARAJAN  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: 3-Dimensional;3D Print;Age;age effect;Age Months;age-related disease;Aging;Architecture;beta catenin;beta-Galactosidase;Biochemistry;Biological;biological adaptation to stress;Biological Models;Biology;bone;bone health;bone mass;Bone structure;Cells;Cellular biology;Computer Models;confocal imaging;Confocal Microscopy;Data;Dendrites;Elements;Engineering;Environment;exercise intervention;experience;Female;fluid flow;Foundations;fracture risk;Goals;graduate student;Health;Health Sciences;imaging approach;Impairment;in silico;in vivo;Individual;interdisciplinary approach;Interdisciplinary Study;Length;Liquid substance;male;Measures;mechanical load;mechanical properties;Mechanics;mechanotransduction;Membrane;Methodology;Methods;microscopic imaging;Modeling;Morphology;multiplexed imaging;Mus;Musculoskeletal structure;novel;old mice;Organ;Osteocytes;Osteogenesis;Osteoporosis;Outcome Study;Pathway interactions;Physics;Physiologic calcification;predictive modeling;Process;Property;public health relevance;Reporter;Research;Research Personnel;Research Proposals;response;Role;sex;shear stress;Signal Pathway;Signal Transduction;Structure;student mentoring;student participation;student training;Students;System;therapy design;Training;ulna;undergraduate student;Visualization;Work

PROJECT_TITLE: Aging Effects on Mechanoregulation of Osteocytes using Multiscale Multiphysics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SMEP-C (80)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Digestive Diseases;Liver Disease

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This project is aimed at developing new approaches to MRI through advances in the use of field cycling, novel spatial encoding strategies, and spin editing methods. The aim is to further a class of open MRI devices that can be made in any shape or size. These developments will pave the way for small footprint, low-cost scanners, making MRI much more accessible for screening and treatment monitoring, especially of common, chronic, and potentially progressive diseases for which MRI is currently underutilized.

PI_NAMEs: CONSTABLE, R TODD (contact);GALIANA, GIGI

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: Acute Disease;American;Automobile Driving;Back Pain;Beds;Characteristics;Chronic;Chronic Disease;comparative efficacy;cost;Coupling;Data;Dedications;design;Development;Devices;Diagnostic;Diffusion;Dimensions;Disease;Effectiveness;Electronics;Elements;experimental study;Fatty acid glycerol esters;fatty liver disease;Geometry;Goals;Head;Hospital Moving;Human;human imaging;Image;Image Enhancement;imaging capabilities;imaging facilities;improved;innovation;intrahepatic;Libraries;Limb structure;Liver;magnetic field;Magnetic Resonance Imaging;Malignant Neoplasms;Manufacturer;Measures;Methods;Modality;Monitor;Motion;motion sensitivity;MRI Scans;Nature;non-alcoholic fatty liver disease;novel;novel strategies;obese person;Organ;Patients;Pattern;Phase;Physiologic pulse;point of care;Population;Productivity;Progressive Disease;Reading;Recommendation;reconstruction;Resolution;RF coil;routine screening;screening;Shapes;Signal Transduction;Slice;soft tissue;Source;Stroke;Structure;Surface;System;Techniques;Technology;Testing;Thinness;Tissues;ultrasound;Vertebral column;Water;whole body imaging

PROJECT_TITLE: Advancing MRI with an open inhomogeneous B0 magnet

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: ES

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: CAROLINA

ORG_NAME: SISTEMA UNIVERSITARIO ANA G. MENDEZ, INCORPORADO

ORG_STATE: PR

PHR: Program Director/Principal Investigator (Last, First, Middle): Mendez, Loyda B. Project Narrative: The proposed research is relevant to public health because it will provide information on how particle pollution can impact biological processes underlying mental health disorders, which can have long-lasting clinical implications. Thus, the proposed research is relevant to NIH/NIEHS as it will contribute fundamental knowledge aimed to identify environmental contributors to psychiatric disorders in order to reduce the burden of disease. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

PI_NAMEs: MENDEZ, LOYDA BEATRIZ (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Academic Research Enhancement Awards;Accounting;Address;Adolescence;Adolescent;Adolescent and Young Adult;Adolescent Development;Affect;Age;Air Pollution;Animal Model;Astrocytes;Attention;Behavior;Behavior assessment;Behavioral;Biological;Biological Process;Brain;brain circuitry;burden of illness;C57BL/6 Mouse;Central Nervous System;Cessation of life;chemokine;Child;Childhood;Clinical;clinically significant;Cognitive;Cognitive deficits;cognitive development;cognitive function;cognitive process;cognitive task;cytokine;Data;density;Development;Developmental Process;Diesel Exhaust;disability-adjusted life years;Discrimination;Disease;Dose;emotion regulation;Emotional;emotional behavior;Environmental Health;Environmental Risk Factor;epidemiology study;executive function;Exploratory Behavior;Exposure to;Family;Female;flexibility;Goals;Grant;Growth;Health;Hispanic;Human Rights;Hyperactivity;IL17 gene;Impaired cognition;Impairment;Individual;Inflammation Mediators;Inflammatory;inflammatory marker;Inflammatory Response;innovation;insight;Institution;Interleukin-1;Interleukin-12;Interleukin-6;Knowledge;Life;life span;Locomotion;long term memory;Low income;male;Measures;Mental disorders;Microglia;Molecular;Morphology;Mus;myelination;National Institute of Environmental Health Sciences;Neurocognitive;neuroimaging;neuroinflammation;neurotoxicity;Outcome;particle;particle exposure;Particulate Matter;Personal Satisfaction;Phenotype;Play;Pollution;postnatal;postnatal development;Predisposition;Prefrontal Cortex;prepuberty;Prevalence;Principal Investigator;Problem Solving;Process;programs;Puberty;Public Health;Research;Risk;Risk Factors;Risk Taking;Rodent Model;Role;Short-Term Memory;social exclusion;social stigma;spatiotemporal;Structure;Students;synaptic pruning;Time;Toxicology;traffic-related air pollution;trait;undergraduate student;United States National Institutes of Health

PROJECT_TITLE: Particle Pollution Impact on Prefrontal Cortex Function During Adolescence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-R (86)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Data Science;Diabetes;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention

ORG_CITY: CHARLOTTE

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

ORG_STATE: NC

PHR: Public Health Relevance Statement Diabetic retinopathy (DR) is a retinal disease that is a leading cause of severe vision loss worldwide. We are developing artificial intelligence (AI) based techniques to collaboratively build diagnostic/prognostic models using multi-institutional data cohorts with a diverse sub-population. Distributed model training (federated learning) will be used to build robust models to improve clinical management of DR.

PI_NAMEs: ALAM, MINHAJ NUR  (contact)

PROGRAM_OFFICER_NAME: GAO, JAMES

PROJECT_TERMS: Affect;Algorithms;Angiography;Arteries;Artificial Intelligence;Attention;Biological Markers;Biomedical Research;Blindness;Blood capillaries;Blood Vessels;Chicago;Classification;Clinical;clinical biomarkers;Clinical Data;Clinical Management;clinical practice;cohort;Consensus;Data;Data Compromising;data modeling;data privacy;Data Reporting;Data Set;data sharing;deep learning model;Democracy;design;Detection;diabetic;diabetic patient;Diabetic Retinopathy;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic algorithm;Disease;distributed model;diverse data;Early Diagnosis;Educational Curriculum;experience;Exposure to;federated learning;firewall;Goals;heterogenous data;Illinois;imaging biomarker;imaging capabilities;improved;Individual;innovation;insight;Institution;Intellectual Property;Intervention;Investigation;Learning;Machine Learning;machine learning model;macular edema;Measures;model building;Modeling;North Carolina;novel;Ophthalmologist;Optical Coherence Tomography;Pathway interactions;patient privacy;Patients;Performance;Population;pre-trained transformer;predictive marker;prevent;Prognosis;prognostic model;proliferative diabetic retinopathy;Protocols documentation;public health relevance;repository;Research;Research Personnel;Retina;Retinal Diseases;Risk Assessment;rural area;Secure;self supervised learning;social;Standardization;success;Taiwan;Techniques;Testing;Texture;Training;Translating;Treatment outcome;trend;undergraduate student;underserved area;Universities;Validation;Veins;Vision;Work

PROJECT_TITLE: Distributed approaches to train machine learning models in diabetic retinopathy

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Pediatric;Social Determinants of Health;Telehealth

ORG_CITY: FLINT

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF MICHIGAN AT FLINT

ORG_STATE: MI

PHR: PROJECT NARRATIVE This qualitative study will interview adolescents aged 14 to 17 years to ask about their perspectives on the benefits of, challenges with, and suggestions for improving telehealth such as video and telephone consultations. Parents rather than adolescents offered their views on telehealth in most prior research. Understanding the perspectives of adolescents can help improve communication with healthcare providers during remote visits and ultimately youth’s health.

PI_NAMEs: KODJEBACHEVA, GERGANA DAMIANOVA (contact)

PROGRAM_OFFICER_NAME: KING, TRACY

PROJECT_TERMS: Adolescent;adolescent health;Adolescent Health Services;aged;Appointment;Caregivers;Caring;Childhood;Communication;Consent;Consultations;Cost Savings;County;COVID-19 pandemic;Data Analyses;Devices;differences in access;Education;Eligibility Determination;Empathy;Enhancement Technology;Ethical Issues;experience;Feeling;Future;Health;Health Care Costs;Health education;Health Personnel;Health Services;Healthcare;Hour;Household;Housing;improved;Individual;innovation;Internet;Interview;Joints;Low income;Manuscripts;Michigan;mobile application;Outcome;Outcomes Research;Parents;patient-clinician communication;Patients;Pediatric Research;pediatrician;Persons;preference;Prevention;Privacy;Privatization;Publications;Publishing;Qualitative Research;Randomized, Controlled Trials;recruit;Reduce health disparities;remote health care;remote visit;Research;Sampling;satisfaction;sociodemographic group;sociodemographics;socioeconomics;Speed;Students;Suggestion;Surveys;symposium;Technology;telehealth;Telemedicine;Telephone;Telephone Interviews;Thinking;Time;Training;Transcript;Travel;Trust;university student;video visit;Visit;Writing;Youth

PROJECT_TITLE: Benefits of, challenges with, and suggestions for improving pediatric telehealth: The perspectives of adolescents

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Pain Research;Palliative Care

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE This project will develop and establish the content validity, and preliminary convergent validity and test-retest reliability of the Palliative Care Readiness (PALCARE) tool in determining readiness for early palliative care (PC) among older adults with cancer. The resulting tool will allow the primary oncology team to assess readiness for early PC in this population, help provide targeted PC in the domains where they feel ready, and help in the development and implementation of interventions aimed at improving readiness in PC domains where they do not yet feel ready. Ultimately this project will improve early PC utilization among older adults with cancer and improve their quality of life.

PI_NAMEs: PARAJULI, JYOTSANA  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Adult;age related;Appointment;Area;Assessment tool;Awareness;cancer diagnosis;cancer type;care costs;care systems;Caring;Cessation of life;Chaplain;Clinical Nurse Specialists;Clinical Practice Guideline;Clinical Research;cognitive interview;Consensus;depressive symptoms;Development;Device or Instrument Development;Diagnosis;Discipline of Nursing;Disease;Early Intervention;effectiveness evaluation;Elderly;end of life;end of life care;Ensure;Environment;Ethics;Ethnic Origin;experience;Extramural Activities;Family;Family Caregiver;Focus Groups;Funding;Goals;graduate student;Grant;hands on research;Health;Health Sciences;Health system;Hearing;human centered design;human old age (65+);implementation intervention;improved;innovation;insight;instrument;Interdisciplinary Study;Intervention;Intervention Studies;Interview;Knowledge;Life;low socioeconomic status;Malignant Neoplasms;Measures;member;Methods;Moods;multiple chronic conditions;North Carolina;Nurses;Occupations;older adult;Oncology;Outcome;pain relief;Palliative Care;Patients;Perception;Persons;physical symptom;Physicians;Physiological;Population;prevent;Principles of law and justice;Process;Provider;psychologic;psychological symptom;Psychometrics;Qualifying;Quality of life;racial diversity;racial minority;Readiness;Recommendation;reduce symptoms;Religion;Research;Research Design;Research Training;Resources;response;Rural;rural area;social;Social Workers;Spirituality;Standardization;stem;Structure;Students;Surveys;Survival Rate;Symptom Burden;symptom management;symptomatic improvement;Symptoms;Techniques;Testing;tool;tool development;undergraduate student;United States;United States National Institutes of Health;Universities;Unmarried;uptake;urban residence;Validation;Validity and Reliability

PROJECT_TITLE: Development and Initial Validation of a Palliative Care Readiness Tool for Older Adults with Cancer.

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: OD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: EUGENE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE This project will generate a resource of rigorously validated, reproducible, and translatable animal disease- models. A bioinformatics pipeline will be used to analyze and prioritize sequence variants of unknown significance from patients for study. Humanized zebrafish models of the patient variants will be generated, validated, and deposited at the NIH-funded Zebrafish International Resource Center.

PI_NAMEs: WESTERFIELD, MONTE  (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Affect;Alleles;Animal Disease Models;Animal Experimentation;Animal Model;Area;bioinformatics pipeline;Biological Assay;Biology;Candidate Disease Gene;candidate validation;Cells;Clinical;clinical center;clinical diagnostics;clinical phenotype;clinical research site;Collaborations;Communities;cost effective;CRISPR/Cas technology;Data;Data Coordinating Center;Databases;Deposition;developmental genetics;Diagnosis;Diagnostic;diagnostic tool;Disease;Ensure;exome;exome sequencing;Family member;Funding;gene discovery;gene function;Genes;Genetic;Genetic Diseases;genetic information;Genetic Models;genetic variant;genome resource;genome sequencing;Genomics;Genotype;homologous recombination;Human;human data;human disease;Human Genetics;human model;improved;Individual;individual patient;Information Networks;insight;interest;International;Laboratories;Laboratory Research;meetings;Metadata;Methods;model organism;Modeling;Molecular;molecular phenotype;mutant;Mutation;novel;Pathogenesis;Pathogenicity;Patients;Phenotype;phenotypic data;prevent;Rare Diseases;rare genetic disorder;rare variant;Records;Recurrence;Reproducibility;Research;Research Personnel;Resources;Standardization;Symptoms;Technology;transcriptomics;United States National Institutes of Health;Validation;Variant;variant of unknown significance;whole genome;Work;Zebrafish

PROJECT_TITLE: Resource of zebrafish models of human diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Y (55)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: LAS VEGAS

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: Project Narrative All life forms require their genetic material to be organized and packaged into cells, but this genetic sequestration often silences gene expression. Here, the mechanism that relieves the silencing of virulence genes in the bacterial pathogen Shigella, will be studied by undergraduates and graduate students at the University of Nevada Las Vegas. The primary focus of these studies will be a newly identified ligand of the key anti-silencing protein, VirB.

PI_NAMEs: WING, HELEN J (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Alanine;Bacteria;Bacterial Physiology;Binding;Binding Proteins;Biochemical;Biological Assay;Body Temperature;Cells;Complex;Data;dimer;Distant;DNA;DNA Binding;DNA-Binding Proteins;Elements;Exhibits;experimental study;Gene Expression;Gene Silencing;Genes;Genetic;genetic approach;Genetic Materials;Genetic Screening;Genetic Transcription;Goals;graduate student;Histones;Human body;human disease;Hydrolysis;in vitro Assay;innovation;insight;Life;Ligands;Link;Literature;Measures;Mediating;member;Modeling;Molecular Conformation;mutant;Nevada;novel;nucleoside triphosphate;pathogenic bacteria;Phenotype;plasmid DNA;Plasmids;Play;Positioning Attribute;Process;promoter;Proteins;Publishing;Role;segregation;Shigella;Shigella flexneri;Site;Structure;Superhelical DNA;Temperature;Testing;Transcriptional Regulation;undergraduate student;United States National Institutes of Health;Universities;Virulence;virulence gene;Work

PROJECT_TITLE: Understanding transcriptional silencing & anti-silencing mechanisms in Shigella

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (80)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE The etiology of inflammatory bowel disease is largely unknown. In an unbiased forward genetic screen for mouse mutants susceptible to experimental colitis, we found that the Golgi protein TVP23B is critical for regulating goblet and Paneth cell function in the intestine via glycosylation. Our work is focused on understanding the function of TVP23B in regulating intestinal immune homeostasis.

PI_NAMEs: TURER, EMRE EROL (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Animals;anti-microbial peptide;Bacteria;Bacterial Translocation;Binding;Bone Marrow;Cell Differentiation process;Cell Lineage;Cell Maintenance;Cell Physiology;Cells;Chemicals;Chronic;Citrobacter rodentium;Colitis;Colon;Complex;Confocal Microscopy;Crohn's disease;Defect;Disease;Endoplasmic Reticulum;Enzymes;Epithelial Cells;Epithelium;epithelium regeneration;equilibration disorder;Essential Genes;Ethylnitrosourea;Etiology;Family;Functional disorder;gastrointestinal infection;Gel;Genes;Genetic Screening;glycosylation;Goals;Goblet Cells;Golgi Apparatus;golgi apparatus membrane;granule cell;gut microbiota;Hematopoietic;Homeostasis;Homologous Gene;host microbiome;host-microbe interactions;Human;Immune;Immune system;Immunity;in vivo;Infection;Infectious colitis;Inflammation;Inflammatory Bowel Diseases;Inflammatory Response;insight;Integral Membrane Protein;intestinal barrier;Intestinal Diseases;intestinal epithelium;intestinal homeostasis;Intestines;Knowledge;Label;Maintenance;Mediating;member;Membrane Proteins;Microbe;microbiota;Modeling;Molecular;Morphology;Mucins;Mucous body substance;Mucous Membrane;Mus;Mutagens;mutant;Mutant Strains Mice;Mutation;Natural regeneration;Paneth Cells;Pathogenicity;Pathology;Pathway interactions;Penetration;Phenotype;Physiologic pulse;Play;Predisposition;prevent;progenitor;protein transport;Proteins;Proteome;radioresistant;Regenerating islet derived protein 3-Gamma;Role;Secretory Cell;segregation;Severities;single-cell RNA sequencing;Sterility;Stress;Structure-Activity Relationship;Surface;Testing;Thick;trafficking;trans-Golgi Network;transcriptome sequencing;Ulcerative Colitis;Vacuole;Vesicle;Work;Yeasts

PROJECT_TITLE: TVP23B and Golgi Mediated Control of Intestinal Secretory Cells

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Drug overdose is the leading cause of accidental death in the United States. While opioid overdoses comprise most overdose deaths, stimulant overdose deaths are rising. This project examines an important but missed opportunity—non-fatal overdose—to improve Veterans’ health care and health outcomes. To improve post- overdose care, the Veterans Health Administration developed a national clinical note template—the Suicide Behavior and Overdose Report (SBOR)—which is currently recommended for unintentional overdoses (majority of overdoses) but will soon be mandated. However, the SBOR is currently optimized to address opioid, not stimulant, overdose. Also, despite the promise of the SBOR to improve post-overdose care, unknown is the extent to which clinicians are using it and whether its use improves post-overdose care as intended. This project will fill a great need to understand how to improve the SBOR and, ultimately, post- overdose treatment for Veterans who have non-fatal overdoses and remain at high risk for poor outcomes.

PI_NAMEs: OLIVA, ELIZABETH M. (contact)

PROJECT_TERMS: Accidents;Accounting;Address;Adoption;Age;care providers;Caring;Cause of Death;Cessation of life;Clinical;clinical care;Cocaine;Community Healthcare;contingency management;Data;Data Reporting;data repository;data warehouse;design;Dimensions;Disease Management;Disparity;Emergency Medicine;Ensure;Ethnic Origin;Event;evidence base;Evidence based treatment;experience;Feedback;follow-up;Future;Gender;Harm Reduction;Health;Health Personnel;Healthcare;Heroin;high risk;Homelessness;implementation facilitators;improved;Individual;innovation;Intervention;Interview;Justice;Massachusetts;Medical Records;Medicare;medication for opioid use disorder;Mental Health;Methamphetamine;Methodology;Modeling;mortality;Naloxone;naloxone dispensing;operation;Opioid;opioid mortality;opioid overdose;Outcome;Overdose;overdose death;overdose education;overdose prevention;Patient Monitoring;Patients;Pharmaceutical Preparations;Policies;prevent;Process;programs;Provider;psychostimulant;Race;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reporting;Research;response;Risk Factors;risk mitigation;Role;rurality;Services;social health determinants;social stigma;Standardization;Stimulant;Stimulant overdose;stimulant use disorder;Substance Use Disorder;suicidal behavior;Suicide;Suicide prevention;synthetic opioid;Translating;treatment disparity;Treatment outcome;trend;United States;uptake;Veterans;Veterans Health Administration

PROJECT_TITLE: Strategies to improve Utilization of Post-overdose Evidence-based Risk mitigation among Non-fatal Overdoses in VA (SUPER NOVA)

STUDY_SECTION_NAME: Special Emphasis Panel[HSR9]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Heart dysfunction is now the leading cause of death in patients with Duchenne muscular dystrophy (DMD). The central objectives of this proposal are to combine genetic differences with blood and imaging markers to help predict development of significant heart dysfunction and scar. These aims have the potential to decrease the size and cost of therapeutic clinical trials for DMD heart disease, speeding up the adoption of new therapies and improving quality of life in boys and men with DMD.

PI_NAMEs: SOSLOW, JONATHAN HARVEY (contact)

PROGRAM_OFFICER_NAME: XU, LEI

PROJECT_TITLE: Prospective Development of a Multimodal Biomaker Platform for Predictive Risk Stratification of Cardiac Disease in Duchenne Muscular Dystrophy


PHR: Knee osteoarthritis (OA) is a leading cause of premature disability and a substantial public health burden that is disproportionately borne by Veterans. There are no drugs to halt or reverse advanced OA. Thus, treatment of earlier OA is needed. The Targeting Osteoarthritis Pain and Progression (TOPP) Collaborative Merit Review aims to establish necessary preclinical and clinical information to improve understanding of how OA develops and to identify new treatments for different types and stages of OA. The degenerative meniscus tear (DMT) might be an early sign of knee OA. This means some DMT patients may already have biological knee OA even though their Xrays don’t yet show OA. This particular research project will examine if certain proteins in joint fluid, blood and urine predict whether pain and OA become better or worse after arthroscopic partial meniscectomy (APM). It will also contribute critical information and biospecimens for use in the TOPP collaboration so better treatments can be developed to help Veterans and others with knee OA.

PI_NAMEs: CHU, CONSTANCE R (contact)

PROJECT_TERMS: Age;Animal Model;Award;Biological;Biological Markers;Biology;biomarker selection;Blood;bone;burden of illness;Caring;Cartilage;Chronic disability;chronic pain;Clinical;Clinical Data;Clinical Trials;clinically relevant;Cluster Analysis;cohort;Collaborations;cytokine;Data;Degenerative polyarthritis;Development;disability;Disabling;Disease;Disease Pathway;early detection biomarkers;Early treatment;Environment;experience;follow-up;Funding;General Population;Goals;Healthcare Systems;Heterogeneity;Human;Image;Immune;improved;Inflammation;inflammatory marker;Interleukin-13;interleukin-17E;Interleukin-4;joint injury;Joints;Knee;Knee Osteoarthritis;knee pain;Knowledge;Link;Liquid substance;Magnetic Resonance Imaging;Measures;mechanical stimulus;Mechanics;member;meniscal tear;middle age;Modification;Molecular;Molecular Disease;multidisciplinary;Nerve;Nerve Growth Factors;new therapeutic target;novel;novel therapeutic intervention;Orthopedics;osteoarthritis pain;Outcome;Pain;pain reduction;Pathogenesis;Pathway interactions;Patient Outcomes Assessments;Patients;Pharmaceutical Preparations;Phenotype;Physical therapy;Plasma;Population;pre-clinical;Precision therapeutics;premature;prevent;Principal Component Analysis;Procedures;Proprotein Convertase 1;Proprotein Convertase 2;prospective;Proteins;Protocols documentation;Public Health;radiological imaging;Relaxation;Reporting;Research Project Grants;response;Response to stimulus physiology;Roentgen Rays;Sampling;Scientist;Serum;sham surgery;Signal Transduction;Specimen;Stem Cell Factor;Stratification;Surgeon;symptom treatment;Synovial Fluid;Synovial Membrane;Testing;Thick;Tissue Sample;United States National Institutes of Health;unsupervised clustering;Urine;Veterans;Work

PROJECT_TITLE: BCCMA: Targeting Osteoarthritis Pain and Progression: Defining biologic and inflammatory markers associated with rapid progression


ORG_NAME: JESSE BROWN VA MEDICAL CENTER

PHR: Hypercapnia, or elevation of the level of carbon dioxide (CO2) in the body, commonly develops in patients with advanced lung diseases, and is associated with frequent lung infections and an increased risk of death. This project will determine how hypercapnia leads to more and severe infections with influenza virus, one of the most common reasons for patients with chronic lung disease to become seriously ill or die. The findings from this research will lay the basis for future studies aimed at preventing the deleterious effects of hypercapnia on the immune system.

PI_NAMEs: SPORN, PETER H (contact)

PROJECT_TERMS: Acute;adverse outcome;Alveolar;Alveolar Macrophages;Attenuated;Bacterial Infections;Blood;Breeding;Carbon Dioxide;Cells;Chronic lung disease;Chronic Obstructive Pulmonary Disease;community acquired pneumonia;Cystic Fibrosis;DNA Methylation;Drosophila genus;Exhibits;Future;Gene Expression;Genes;Genetic;Genetic Transcription;Growth;Homeobox;Host Defense;Human;Hypercapnia;Hypermethylation;Immune;Immune system;Immunosuppression;improved outcome;Infection;Inflammation;Inflammatory;Influenza A virus;influenza infection;influenzavirus;Injury;Interferon Type I;Intubation;Investigation;Laboratories;Lung;Lung Diseases;Lung infections;lung injury;Macrophage;Mediator;Methylation;monocyte;mortality;mortality risk;mouse model;Mus;Myelogenous;novel;Nucleic Acid Regulatory Sequences;Orthologous Gene;Outcome;Pathway interactions;Patients;preservation;prevent;recruit;Reporting;Research;response;Risk Factors;Testing;Tissues;transcription factor;Viral;Viral Genes;Viral Pneumonia;Virus Diseases;Virus Replication;ZFHX3 gene;Zinc Fingers

PROJECT_TITLE: Hypercapnia and Suppression of Antiviral Host Defense


ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: GA

PHR: Posttraumatic stress disorder (PTSD) is an important priority for the Veterans Administration, but treatments to date utilizing medications and / or psychotherapy have had limitations. Electrical treatments represent a new horizon in the treatment of PTSD and psychiatric disorders in general, and new non-invasive treatments avoid the high cost, and lack of reimbursement by insurance companies that limited wide-spread implementation of implanted stimulation devices. This project will look at a novel new possible treatment for PTSD that could represent a paradigm shift in this disorder called non-invasive transcutaneous cervical (neck) Vagal Nerve Stimulation (tcVNS) and how it affects brain and physiological responses to stress in veterans with PTSD as well as effects of long term treatment on PTSD symptoms.

PI_NAMEs: BREMNER, JAMES DOUGLAS (contact)

PROJECT_TERMS: Acute;Affect;Amygdaloid structure;Anesthetics;Anterior;Blood;Brain;Brain region;Cardiac;Cardiovascular system;Cervical;combat veteran;cost;Data;Department of Defense;Devices;Disease;Drug Targeting;Economics;Electric Stimulation;Emotions;Evaluation;Exposure to;follow-up;Generations;Health Care Costs;Hippocampus;Home;Immune;immune function;Immune response;Immunologic Markers;Implant;implantable device;implantation;Inflammatory;inflammatory marker;Insula of Reil;Insurance;Interferon Type II;Interleukin-6;Intervention;Long-Term Effects;Measurement;Measures;Medial;Memory;Mental disorders;Mental Health Services;Morbidity - disease rate;Nerve;neurobiological mechanism;Neurobiology;novel;novel strategies;Operative Surgical Procedures;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Photoplethysmography;Physiological;Physiology;Placebos;Positron-Emission Tomography;Post-Traumatic Stress Disorders;Prefrontal Cortex;prevent;Procedures;Productivity;Psychiatry;Psychotherapy;Radiolabeled;Randomized;reduce symptoms;Research;Resolution;response;Science;side effect;standard care;Stress;stress reduction;Surgical complication;symposium;Symptoms;System;Testing;traumatic event;traumatic stress;Travel;treatment response;United States Department of Veterans Affairs;vagus nerve stimulation;Vagus nerve structure;vasoconstriction;Veterans;Water;wearable device

PROJECT_TITLE: Transcutaneous Vagal Nerve Stimulation in Veterans with Posttraumatic Stress Disorder


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Diseases affecting the filters of the kidney (podocytes and glomeruli), such as diabetes, are the leading cause of end stage kidney disease (ESKD). Eleven percent of Veterans meet the criteria for chronic kidney disease (CKD), which leads to ESKD and premature death from cardiovascular disease. As a kidney doctor at the VA and in the South Carolina Army National Guard, I frequently see patients with CKD, and it is difficult to tell them there are very few specific therapies to treat CKD. A safe, approved, and efficacious drug would be a major advance. The goal here is to validate a novel therapeutic target, the beta 2 adrenergic receptor (β2-AR), activation of which we showed accelerates recovery of kidney function following injury, including in a diabetic mouse model. Formoterol, which activates the β2-AR, is an approved drug with an excellent safety profile used to treat chronic obstructive pulmonary disease (COPD). This application investigates, using mouse models and a retrospective cohort study of Veterans, the utility of repurposing β2-AR activators such as formoterol for the treatment of CKD.

PI_NAMEs: LIPSCHUTZ, JOSHUA H (contact)

PROJECT_TERMS: Acceleration;Address;Adrenergic Receptor;Adriamycin PFS;Affect;Agonist;Animal Experiments;ATP Synthesis Pathway;beta-2 Adrenergic Receptors;Biogenesis;Bioinformatics;Biology;Cardiovascular Diseases;CD2-associated protein;Cell Culture Techniques;Cells;Cessation of life;Chronic Kidney Failure;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Trials;Cohort Analysis;Data;Development;Diabetes Mellitus;Diabetic mouse;Diabetic Nephropathy;Diagnostic;Disease;drug discovery;efficacious treatment;efficacy evaluation;Electron Transport;End stage renal failure;Event;experimental study;Focal and Segmental Glomerulosclerosis;formoterol;Functional disorder;gene induction;Genes;glomerular filtration;glomerular function;Goals;Health;Hereditary nephritis;Homeostasis;Hour;Human;improved;In Vitro;in vivo;in vivo Model;injured;Injury;injury recovery;intraperitoneal;Investigation;Kidney;Kidney Diseases;kidney dysfunction;Knockout Mice;Lupus Nephritis;Mediating;Mitochondria;mitochondrial dysfunction;Molecular Target;mouse model;Mus;Mutation;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;NPHS2 protein;Oral;Patients;Pharmaceutical Preparations;Plasma;Play;podocyte;pre-clinical assessment;premature;preservation;prevent;programs;prospective;Proteinuria;Publishing;Puromycin;randomized, clinical trials;Recovery;Renal function;Renal glomerular disease;repaired;Research;Retrospective cohort;Retrospective cohort study;Role;Safety;slit diaphragm;South Carolina;Structure;System;Testing;Therapeutic;therapeutic target;Validation;Veterans

PROJECT_TITLE: The role of beta agonists in the treatment of chronic kidney disease


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

PHR: The proposed research is relevant to public health and the mission of NIH because identifying unique combination regimens and characterizing their anti-tumor mechanisms may ultimately result in novel therapies for pancreatic cancer.

PI_NAMEs: MUNSHI, HIDAYATULLAH G. (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: antitumor effect;Antitumor Response;Binding;Bromodomain;Bromodomains and extra-terminal domain inhibitor;cancer cell;CD8-Positive T-Lymphocytes;Cells;Chronic;Clinical;clinical translation;Clinical Trials;Collagen;Combined Modality Therapy;Complex;Data;Development;effector T cell;Elements;Eukaryotic Initiation Factors;expectation;Feedback;Fibroblasts;Genetic Transcription;Goals;Growth;Histone Acetylation;Human;Immunotherapy;improved outcome;in vivo;ineffective therapies;Infiltration;inhibitor;innovation;insight;interest;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Messenger RNA;Mission;mouse model;mRNA Translation;novel;novel therapeutic intervention;novel therapeutics;Organoids;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;Phosphorylation;Phosphotransferases;programmed cell death ligand 1;programmed cell death protein 1;Protein Family;Proteins;Public Health;Publishing;Reaction;Reader;Regimen;Research;Resistance development;Role;Solid Neoplasm;Specimen;Stromal Cells;synergism;T cell infiltration;Tertiary Protein Structure;Testing;Transgenic Mice;tumor;tumor growth;Tumor-associated macrophages;tumor-immune system interactions;United States National Institutes of Health

PROJECT_TITLE: Co-targeting BET Bromodomain Proteins and MNK Kinases in Pancreatic Cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative While goal-directed behaviors are essential for animal survival and dramatically disrupted in neuropsychiatric disease, the cellular mechanisms supporting these processes remain unclear. The striatum is a key node in mediating goal-directed function via complex interactions between spiny projection neurons and local circuit inhibitory neurons. This proposal employs viral-genetic, physiological, electrochemical, 2-photon imaging and behavioral methods to explore how a specific subtype of striatal interneuron – the low-threshold-spiking cell – modulates goal-directed striatal output.

PI_NAMEs: FUCCILLO, MARC V (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Acute;Anatomy;Animals;Automobile Driving;Behavior;Behavioral;Calcium;Calcium Signaling;cell type;Cells;Cognitive;Complex;Corpus striatum structure;Data;Dendrites;Dopamine;dopaminergic neuron;Down-Regulation;driving behavior;Electrophysiology (science);Excitatory Synapse;Exhibits;follow-up;Goals;Image;improved;in vivo;in vivo imaging;inhibitory neuron;integration site;Interneurons;Laser Scanning Microscopy;Learning;Literature;Maps;Measures;Mediating;Mediator;Methods;Microdialysis;Motivation;Motor;motor control;Motor output;neural circuit;Neuromodulator;neuronal excitability;Neurons;neuropsychiatric disorder;neurotransmission;novel;Operant Conditioning;Optics;optogenetics;Outcome;Output;Pathway interactions;Performance;Periodicity;Pharmacology;Physiological;Population;Population Heterogeneity;Process;Property;Regulation;response;Rewards;Role;Scanning;sensor;Shapes;Signal Transduction;Slice;Specificity;Synapses;Synaptic plasticity;System;Testing;Thalamic structure;transmission process;two photon microscopy;two-photon;Viral;virus genetics;Work

PROJECT_TITLE: A Novel Role for Local Striatal Interneuron Regulation of Goal-Directed Action

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: Spinal cord injury and disorders (SCI/D) are a substantial health concern impacting about 273,000 Americans and 45,000 veterans. Restoring lost function is the goal of regenerative and rehabilitative therapeutic approaches for SCI/D. The VA Gordon Mansfield Spinal Cord Injury Consortium (VA-GMSCIC) is an effort to develop late-stage translational therapeutics in a nonhuman primate (NHP) model in preparation for clinical testing of emerging therapies. Prior and current funding has focused on multifaceted data collection, with multiple centers collaboratively collecting data on the same subject, each with specific domain of expertise. The current VA Merit Award built a Federated Data Commons to optimize decision-support, and knowledge- discovery across all data from VA-GMSCIC rehabilitation and regeneration studies. The renewal will integrate translational Electronic Health Records (tEHR), robotic rehabilitation, neuromodulation and machine intelligence tools to support advanced safety/efficacy studies.

PI_NAMEs: FERGUSON, ADAM R (contact)

PROJECT_TERMS: Acceleration;American;Artificial Intelligence;Autonomic Dysfunction;Award;Behavior;Behavior assessment;Big Data;Big Data Methods;Big Data to Knowledge;brain machine interface;care burden;Cellular biology;Cervical;Cervical spinal cord injury;Chronic;Clinical;clinical translation;cloud based;Collaborations;Complex;cortex mapping;cost;dashboard;Data;Data Analyses;Data Collection;Data Commons;data ingestion;data integration;data reuse;Data Science;data sharing;data streams;Databases;Dedications;deep neural network;Development;Devices;digital;digital technology;Disease;Economic Burden;efficacy study;electronic data;Electronic Health Record;Electrophysiology (science);Ensure;FAIR principles;FDA approved;federated data;Forelimb;functional restoration;Funding;Future;Goals;grasp;Hand functions;Health;health record;High Prevalence;Histology;Human;Image;improved;Individual;informatics tool;Infrastructure;Ingestion;Injury;innovation;Investments;kinematics;Knowledge Discovery;Laboratories;Learning;Machine Learning;machine learning pipeline;Measures;Medical;Modeling;Modernization;Molecular Biology;Motor;multidimensional data;multimodal data;multimodality;Natural regeneration;Neurologic;neurological rehabilitation;neurophysiology;neuroregulation;Neurostimulation procedures of spinal cord tissue;nonhuman primate;novel;novel therapeutics;open source;Pain;Paralysed;Performance;persistent symptom;Physiology;Population;Positioning Attribute;pre-clinical;precision medicine;Preparation;Primates;productivity loss;Programming Languages;Public Health Informatics;Pythons;Quality of life;Recovery;regenerative;Regenerative research;regenerative therapy;Rehabilitation therapy;Research;research clinical testing;Resolution;Retrieval;robot rehabilitation;robotic device;Robotics;Rodent Model;Safety;safety study;Sensory;shared database;Side;Site;spasticity;Spinal cord injury;Structure;structured data;success;Syndrome;System;Taxonomy;Technology;Testing;Therapeutic;therapeutic candidate;Time;tool;Training;Translating;translation to humans;translational pipeline;translational study;translational therapeutics;Translations;usability;Veterans;Work

PROJECT_TITLE: Harnessing big-data for plasticity and rehabilitation in translational SCI

STUDY_SECTION: RRDA

STUDY_SECTION_NAME: Spinal Cord Injury/Disorders & Neuropathic Pain[RRDA]


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: A majority of trauma-exposed Veterans continue to experience PTSD symptoms after evidence-based treatment (EBT). Anhedonia, i.e., reduced positive affect and reward responsiveness, is common in trauma- exposed Veterans, and impaired reward responsiveness has been implicated as a risk factor for developing PTSD and poor treatment response. The proposed research will use computational modeling and functional neuroimaging to identify individual markers of reward function and test the usefulness of such markers in predicting successful reduction of PTSD symptoms following EBT. By using a detailed mechanistic framework of reward processing, this research will help improve our understanding of PTSD complex clinical profile and to develop predictive tools to determine which trauma-exposed Veterans are at risk of poor EBT response. Results from this research may also help identify specific reward processing targets to develop adjunctive treatments to improve the effectiveness of psychological care for Veterans exposed to trauma.

PI_NAMEs: HARLE, KATIA  (contact)

PROJECT_TERMS: Accounting;Address;Affect;Aftercare;Anhedonia;Anterior;Anxiety;anxiety symptoms;arm;Bayesian Analysis;Bayesian learning;Bayesian Modeling;Bayesian Prediction;Behavior assessment;Behavioral;Belief;Biological Assay;Brain;Caring;cingulate cortex;Clinical;Clinical assessments;clinical outcome assessment;clinical predictors;Cognition;Cognitive;cognitive process;cognitive training;Complex;Computer Models;Diagnosis;Diagnostic;Dorsal;Effectiveness;Enrollment;Environment;Event;Evidence based treatment;expectation;experience;flexibility;follow-up;Functional Magnetic Resonance Imaging;Goals;Impairment;improved;Individual;insight;interest;Learning;Link;Measures;Medial;Mental Depression;Modeling;neural;neural correlate;neuroimaging;novel;Outcome;Outcome Study;Participant;Perception;personalized medicine;Play;Policies;Post-Traumatic Stress Disorders;predict clinical outcome;Prediction of Response to Therapy;predictive marker;predictive tools;Prefrontal Cortex;Preventive;Probability;Process;psychiatric comorbidity;Psychiatric therapeutic procedure;Psychiatry;psychologic;Recovery;recruit;relapse prevention;Research;response;reward anticipation;reward processing;Rewards;Risk;Risk Factors;Role;Severities;Signal Transduction;Social Conditions;Substance Addiction;substance use;Symptoms;Testing;Time;tool;Trauma;trauma exposure;Treatment outcome;treatment planning;treatment response;Triage;Ventral Striatum;Veterans

PROJECT_TITLE: Neuro-computational predictors of treatment responsiveness in trauma-exposed Veterans.


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative To address the dual needs of parents for support in navigating Autism Syndrome Disorder (ASD) services and maintaining positive family functioning, we propose to test Autism Parent Navigators (APN), an innovative in-home, peer support model for parents with a young child recently diagnosed with ASD. Extensive pilot work over the past 3 years has generated evidence of feasibility, acceptability, and impact. We will assess the efficacy of APN in a randomized trial with 180 families; test the mediating pathways through which APN impacts outcomes; and assess whether baseline parent characteristics, child characteristics, or program processes moderate outcomes.

PI_NAMEs: FEINBERG, MARK ETHAN (contact);HOCK, ROBERT

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Address;Aggressive behavior;Anxiety;Autism Diagnosis;autism spectrum disorder;autistic children;Behavioral;Birth;Characteristics;Child;Child Behavior;Child Rearing;cohort;Conflict (Psychology);cost;cost effective;Country;Data;design;Diagnosis;Disease;Early Intervention;efficacy evaluation;Environment;evidence base;Family;Family Relationship;family support;Family Violence;Financial Hardship;flexibility;follow-up;Foundations;Health Services;Health Services Accessibility;Healthcare;high risk population;Home;Home visitation;improved;Individual;innovation;Intervention;Life;Manuals;Mediating;Medical;Mental Depression;Mental Health;Mentors;Modeling;Monitor;Outcome;parental influence;parenting intervention;Parents;Pathway interactions;Patient Recruitments;peer coaching;peer support;preventive intervention;primary outcome;Problem behavior;Procedures;Process;programs;Quality of life;Randomized;randomized trial;recruit;Reporting;Schools;secondary outcome;Self Efficacy;Services;skills;Social Work;South Carolina;Strategic Planning;Stress;stressor;Structure;Syndrome;Testing;Training;treatment program;Voice;Work

PROJECT_TITLE: Test of an Innovative, Scalable Support Program for Parents with a Young Child Recently Diagnosed with Autism Spectrum Disorder

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Caregiving Research;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Exposures to toxic metals and psychological and social stressors in early life are uniquely and jointly associated with poorer child cognitive and socioemotional development. This study recognizes that physical, social, and psychological risk factors tend to cluster; thus, we propose to examine how profiles of prenatal exposures to concurrent toxic metals and psychological and social stressors are associated with child developmental outcomes. By then rigorously examining the moderating effects of caregiving experience, this study has the potential to identify strategies to mitigate the effects of early risk factors experienced across the physical and social environments on child development.

PI_NAMEs: WYLIE, AMANDA C. (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Achievement;Address;Age;Age Months;Arsenic;Behavior;Brain;Buffers;Cadmium;career development;caregiving;Categories;Chemicals;Child;Child Development;Cognitive;Data;Decision Making;Dedications;Development;Diet;Discipline;Disparity;early childhood;early experience;Emotional;Ensure;Environmental Exposure;Environmental Science;Equilibrium;executive function;experience;Exposure to;Fetal Development;Foundations;Future;Goals;Health Sciences;indexing;Individual;Infant Development;interdisciplinary collaboration;Intervention;Joints;Language;Lead;Life;Longitudinal Studies;Measures;Mentorship;Modeling;Mothers;multidimensional data;National Institute of Environmental Health Sciences;neurodevelopment;Outcome;Perinatal;person centered;Physical environment;Population;Predictive Factor;prenatal;prenatal exposure;programs;protective factors;psychologic;Psychological Factors;Psychological Stress;psychological stressor;Psychology;psychosocial;Public Health;Research;Risk;Risk Factors;Science;skill acquisition;skills;social;Social Environment;social factors;social stress;social stressor;Social support;stressor;Testing;Toxic effect;toxic metal;toxicant;Training

PROJECT_TITLE: Latent profiles of prenatal exposure to toxic metals and psychosocial risk and protective factors: testing associations with child developmental outcomes and moderations by caregiving experience

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Brain Disorders;Clinical Research;Disability Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE A major barrier to the development of effective treatment options for multiple sclerosis include is the limited specificity of clinical imaging markers for axonal damage, one of the key contributors to disability progression. This project will evaluate the relative influence of demyelination and axonal damage in the development of permanent disability in MS by providing a validated noninvasive MR imaging marker of axonal damage using strong imaging gradients. The tool will be validated through longitudinal and imaging-histopathologic studies and form the basis for identifying clinically relevant imaging outcomes in assessing response to reparative and neuroprotective therapies in MS.

PI_NAMEs: HUANG, SUSIE YI (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Acute;Agreement;Appearance;Autopsy;Axon;axon injury;axonal degeneration;Biological Markers;Brain;brain tissue;Calibration;Chronic;chronic demyelination;Clinic;Clinical;clinical development;clinical imaging;clinically relevant;Cognition;Collaborations;comparison control;connectome;Corpus Callosum;Corticospinal Tracts;Data;Dedications;Demyelinations;density;Development;Diameter;Diffusion Magnetic Resonance Imaging;disability;Disease Progression;Dropout;Educational process of instructing;effective therapy;Electron Microscopy;Evaluation;Evolution;follow-up;Functional disorder;Goals;Histopathology;human imaging;Image;imaging biomarker;imaging study;Impaired cognition;improved;in vivo;in vivo imaging;Inflammatory;insight;instrument;Investigation;Lesion;Lifelong disability;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methods;Microscopic;Morphology;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;Myelin;neuropathology;neuroprotection;non-invasive imaging;Outcome;pathogen;Pathologic;Pathology;Patient Selection;Patients;Persons;physically handicapped;Prevalence;Publishing;remyelination;Research Personnel;Research Support;response;Role;Sampling;serial imaging;spatiotemporal;Specificity;Specimen;Structure;Swelling;targeted treatment;Techniques;Thinness;Time;Tissues;tool;Treatment Efficacy;treatment response;usability;Virulence Factors;water diffusion;white matter;Work

PROJECT_TITLE: Toward a Validated in Vivo Imaging Marker of Axonal Damage Predictive of Progressive Disability in Multiple Sclerosis


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;HIV/AIDS;Infectious Diseases;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

PHR: Project(Narrative( HIV-uninfected individuals born to mothers with HIV are known to exhibit adverse health outcomes in early life, yet the long-term clinical consequences for this population – exceeding 18 million people worldwide – are largely unknown. This project will delineate metabolic and immune sequelae of in utero HIV exposure among HIV-uninfected young adults, and identify mechanisms that may contribute to these outcomes. Only by characterizing lifelong disease risk among HIV-exposed but uninfected individuals can we optimize screening, prevention, and treatment strategies for this group.

PI_NAMEs: FOURMAN, LINDSAY TARA (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: abdominal fat;Address;Adolescent and Young Adult;Adult;Airway Disease;antiretroviral therapy;Award;Behavioral;Biometry;Blood Pressure;career;career development;CD4 Lymphocyte Count;Cells;Child;Clinical;Clinical Investigator;Cohort Studies;Communicable Diseases;comorbidity;comparison control;Data;Dedications;design;Development;Development Plans;Diabetes Mellitus;Disease;disorder risk;DNA Methylation;Endocrinologist;Endocrinology;Epidemiology;Epigenetic Process;Exhibits;Exposure to;Fatty acid glycerol esters;Fetal Development;Functional disorder;Funding;Genes;Glucose Intolerance;Goals;Growth;Health;health determinants;Hepatic;high body mass index;HIV;HIV-exposed uninfected infant;Immune;immune activation;Immunologics;Immunology;Impairment;in utero;indexing;Individual;Infection;Inflammation;inflammatory marker;innovation;International;intrauterine environment;Investments;Lead;lens;Life;Link;Literature;maternal diabetes;maternal obesity;medical schools;Mentors;Metabolic;Metabolic Diseases;Metabolism;methylation pattern;mitochondrial dysfunction;Modification;Molecular;Mothers;novel;Obesity;Outcome;Pathogenesis;Pathologic;Pathway interactions;patient population;peer;Persons;Phenotype;Population;Predisposition;prenatal;prenatal exposure;Prevalence;prevent;Prevention;Prevention strategy;prospective;Prospective Studies;Public Health;Research;research and development;Risk;Risk Factors;Role;screening;skills;social;Testing;Time;Training;training opportunity;treatment strategy;Work;young adult;young mother

PROJECT_TITLE: In Utero HIV Exposure and Metabolic Disease Risk in HIV-Uninfected Young Adults

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW ORLEANS

ORG_DEPT: PEDIATRICS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Infrequent or never testing for HIV has been associated with high rates of infection in Black sexual and gender minority youth (SGMY) indicating a public health imperative to increase routine HIV testing. Social media influencers have been successfully used in consumer marketing; however, they have not been leveraged for HIV prevention efforts despite their potential as a scalable and cost-effective approach for public health intervention. This project will identify and train Black SGMY Instagram influencers, for the first time, to develop and deliver theoretically-grounded persuasive Instagram messages to promote routine HIV testing to their social media networks.

PI_NAMEs: OCASIO, MANUEL A (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Adoption;Age;age group;AIDS prevention;Attention;Attitude;barrier to testing;black men who have sex with men;Black race;Caring;children of color;cis-male;Communities;community based participatory research;cost effective;cost effective intervention;Development;Diagnosis;Diffuse;Diffusion;digital health;Educational workshop;efficacy testing;Enrollment;Epidemic;Ethnic Origin;Evaluation;experience;Facebook;Fright;Gender;gender minority youth;Goals;health communication;health disparity;Health Services Accessibility;HIV;HIV diagnosis;HIV disparities;HIV Infections;Homophobia;Hot Spot;Human immunodeficiency virus test;improved;Inequity;infection rate;innovation;Instagram;Intervention;Knowledge;Latinx;Life Experience;Link;Los Angeles;Maintenance;Marketing;men who have sex with men;Mentored Research Scientist Development Award;Mentors;Mentorship;Meta-Analysis;Methods;Modeling;multidisciplinary;nano;Newly Diagnosed;novel;Personality;Persons;Persuasive Communication;Peru;Population;pre-exposure prophylaxis;prevention service;Public Health;public health intervention;Race;Recommendation;recruit;Reporting;Research;Research Personnel;Risk;sexual minority youth;Site;skills;social media;Social Network;social network intervention;social stigma;Social support;Stigmatization;Target Populations;Testing;theories;therapy development;Time;Training;transgender;transgender women;Trust;trustworthiness;Unsafe Sex;uptake;young adult

PROJECT_TITLE: Diffusing persuasive HIV testing messages: engaging Black sexual and gender minority youth social media influencers


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative For the tens of millions of individuals living with human immunodeficiency virus 1 (HIV-1), antiretroviral therapies are life-saving medicines that prevent the onset of acquired immunodeficiency syndrome (AIDS). Our lab previously reported compounds with anti-HIV-1 activity that belong to a unique class of antiretrovirals not currently used in clinical practice. Here, I aim to determine how these compounds modify the assembled structures of the HIV-1 virion and to establish the biochemical parameters of compound binding to lay the groundwork for the next generation of HIV-1 therapeutics in order to help outpace antiviral drug resistance.

PI_NAMEs: MCFADDEN, WILLIAM MICHAEL (contact)

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Affect;Affinity;analog;Anti-Retroviral Agents;Anti-viral Agents;Anti-viral resistance;antiretroviral therapy;antiviral drug development;Binding;Binding Proteins;Biochemical;Biological Assay;Biological Availability;Capsid;Capsid Proteins;career;Cells;Characteristics;Clinical;clinical practice;combat;Complex;Cryoelectron Microscopy;design;Detection;Deuterium;Dipeptides;Dissociation;Drug resistance;drug resistant virus;Drug Targeting;Electron Microscopy;emerging virus;Epidemic;experimental study;Future;Glycine;high risk;HIV;HIV Infections;HIV-1;Hydrogen;Hydrophobicity;improved;In Vitro;Individual;Infection;insight;Integrase;Integration Host Factors;Label;Life;Mass Spectrum Analysis;Medicine;monomer;Morphology;Multi-Drug Resistance;mutant;Mutation;nanomolar;Nature;Negative Staining;next generation;novel;novel strategies;Nuclear Import;Optics;particle;Patient Care;Patients;peptidomimetics;Pharmacotherapy;Phenotype;Phenylalanine;pressure;prevent;Proteins;Reporting;Research;Resistance;Resolution;Resources;RNA-Directed DNA Polymerase;Role;scaffold;Scanning;Science;Site;skills;stoichiometry;Structure;success;Surface Plasmon Resonance;System;Therapeutic;therapy resistant;Tube;Viral;Viral Drug Resistance;viral fitness;Viral Genome;Virion;Virus;Virus Replication;Visualization

PROJECT_TITLE: Structural and Biochemical Effects of Capsid-targeting Molecules on HIV-1 Capsid Assembly

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F17A-Z(20)]


NIH_SPENDING_CATS: Diabetes;Prevention

PHR: In response to RFA-DK-18-016, we will interrogate human pancreatic tissue and islets from type 2 diabetes (T2D) “staged” (based on clinical information) donors using the range of experimental approaches outlined in the RFA and new experimental approaches. By quickly entering this new data into the publicly available HPAP database, PANC-DB, these efforts will foster research by any investigator interested in T2D.

PI_NAMEs: ATKINSON, MARK A.;BOTTINO, RITA ;BRISSOVA, MARCELA ;FARYABI, ROBERT BABAK;GLOYN, ANNA LOUISE;HOMANN, DIRK ;KIM, SEUNG K;MACDONALD, PATRICK ;POWERS, ALVIN C (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Acceleration;Address;Alberta province;Alpha Cell;Architecture;Atlases;bariatric surgery;Beta Cell;Biological Assay;Biology;biomarker development;Body Weight decreased;Capital;Cellular biology;Characteristics;Clinical;clinical development;clinical phenotype;Collaborations;collaborative approach;Color;Communities;Coupled;Data;data integration;Databases;design;Development;Diabetes Mellitus;Diet;Disease;experience;extracellular;Florida;Fostering;Functional disorder;Genetic Risk;Glucagon;glucose production;Goals;Hepatic;Heterogeneity;Human;Human BioMolecular Atlas Program;Human Genetics;Hyperglycemia;Impairment;improved;Individual;Infrastructure;Insulin;Insulin Resistance;insulin secretion;Insulin-Dependent Diabetes Mellitus;interdisciplinary approach;interest;islet;Islets of Langerhans;Knowledge;Leadership;Life;Medicine;Molecular;Molecular Analysis;Molecular Biology;multimodality;Neonatal;new technology;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Oral;Organ;Organ Donations;Organ Donor;Output;Pancreas;Pathogenesis;Pathology;Pharmaceutical Preparations;Phenotype;Physiology;Positioning Attribute;Prediabetes syndrome;prevent;Process;Productivity;programs;Recording of previous events;Research;Research Personnel;Resolution;Resources;response;Role;Scientist;Site;targeted treatment;Techniques;Technology;therapeutic development;therapy design;Tissues

PROJECT_TITLE: Human Pancreas Analysis Program-T2D


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE  In order to efficiently control energy homeostasis, the brain makes predictions about future caloric needs and food availability in order to invigorate food-seeking behavior. It is know that dopamine neurons encode reward prediction error signals that reinforce learning and guide the development of reward-seeking behavior. This proposal aims to investigate the role of dopamine in lateral hypothalamic area and test the hypothesis that LHA receives prediction error signals from the ventral tegmental area-revealing a novel feeding neural circuit and defining a new role for dopamine in feeding behavior.

PI_NAMEs: SCHAID, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Area;Association Learning;Axon;Behavior;Brain;Calories;Characteristics;Communication;Consumption;Cues;Dangerousness;detector;Development;Dissociation;Dopamine;dopaminergic neuron;Eating;Eating Disorders;Ensure;Excision;experimental study;feeding;Feeding behaviors;Fiber;Food;food consumption;Future;Gymnema sylvestre Gurmarin protein;hedonic;Homeostasis;Hunger;Hypothalamic structure;in vivo;inhibitor;Lateral Hypothalamic Area;Learning;Mus;neural circuit;Neuroanatomy;novel;Nucleus Accumbens;Obesity;Organism;Pattern;Photometry;Play;pleasure;Process;Reporting;response;Rewards;Role;Route;Sensory;Signal Transduction;Source;Structure of nucleus infundibularis hypothalami;Sucrose;sweet taste perception;Taste Perception;Testing;Training;Ventral Tegmental Area;Work

PROJECT_TITLE: A role for hypothalamic dopamine in predicting homeostatic need


NIH_SPENDING_CATS: Behavioral and Social Science;Genetics;Neurosciences

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Nausea is an unpleasant sensation of visceral malaise that has remained poorly understood at a molecular and cellular level. The area postrema is a tiny brain structure that mediates certain nausea responses, and this project will use genetic approaches to explore the functional organization of the area postrema- from how visceral stimuli are detected and encoded to the roles of different cell types and receptors in nausea-associated behaviors. Understanding sensory mechanisms underlying the sensation of nausea may provide new and needed strategies for therapeutic intervention.

PI_NAMEs: LIBERLES, STEPHEN DANIEL (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Ablation;Afferent Neurons;Agonist;Anatomy;Atlases;Axon;Behavior;behavioral response;Brain;Cancer Patient;Cell Surface Receptors;cell type;Cells;cohort;Communication;Conditioned Reflex;Cues;Data;Educational process of instructing;Esthesia;excitatory neuron;Experimental Genetics;experimental study;GCG gene;GDF15 gene;Genetic;genetic approach;genetic signature;ghrelin;Hormones;Image;In Vitro;in vivo;Infection;inhibitory neuron;Intervention;Knock-in Mouse;Knockout Mice;Lesion;Malaise;Maps;Measures;Mediating;Molecular;Monitor;Nausea;Neurons;novel;optogenetics;Organ;pathogen;Pathway interactions;Patients;Pharmaceutical Preparations;Poison;Publishing;receptor;response;Role;sensory input;sensory mechanism;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Stimulus;Structure;Structure of area postrema;success;Testing;Therapeutic;Therapeutic Intervention;tool;Toxin;transcriptome;Treatment Protocols;Visceral

PROJECT_TITLE: Area Postrema Neurons that Mediate Nausea-Associated Behaviors

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Binge alcohol consumption poses a major public health burden in the U.S., leading to increased rates of mortality and other pathophysiologies, such as anxiety and depression. The proposed work will examine how repeated cycles of binge-like alcohol drinking dysregulate serotonin signaling in a discrete neural circuit, which may drive future binge alcohol intake and contribute to negative health outcomes. This may lead to the identification of more effective therapeutic strategies for the treatment of alcohol use disorder.

PI_NAMEs: PINA, MELANIE M (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol use disorder;Alcohol withdrawal syndrome;alcohol-related death;Alcohols;Anxiety;attributable mortality;Automobile Driving;Award;binge drinking;biophysical analysis;Biosensor;Brain region;Cells;Chronic;Complement;Coupled;Darkness;Death Rate;Dependence;designer receptors exclusively activated by designer drugs;Development;Disease;dorsal raphe nucleus;drinking;Economic Burden;Electrochemistry;Electrophysiology (science);experience;experimental study;Fiber;Functional disorder;Future;genetic approach;Health;Heavy Drinking;Heterogeneity;hippocampal pyramidal neuron;In Situ Hybridization;in vivo;Individual;innovation;insight;Intake;Learning;Measures;Mental Depression;Methods;Molecular Profiling;mortality;Mus;neural circuit;neuroadaptation;Neurons;neurotransmission;optogenetics;Organizational Models;Outcome;Pattern;Periodicity;Photometry;Procedures;programs;psychiatric symptom;Public Health;Receptor Signaling;Research;Research Personnel;Risk;Role;Scanning;Series;Serotonergic System;Serotonin;serotonin receptor;Serotonin Receptor 5-HT2A;Signal Transduction;Site;skills;Synaptic Transmission;System;targeted treatment;Techniques;Testing;therapeutically effective;Training;treatment strategy;United States;uptake;Viral;Viral Vector;Work

PROJECT_TITLE: Alcohol-induced alterations in orbitofrontal cortex serotonin signaling

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Project Narrative Synthetic tailoring of polypharmacological drugs is often difficult, as the most appropriate targets may not be readily apparent and therefore few roadmaps exist to guide chemistry. In this application we propose a multidisciplinary approach for accessing novel target and chemical space so as to derive highly precise polypharmacological compounds. By combining chemical and genetic modifier screens, with computational modelling, we will identify distinct kinases that can strongly enhance (‘pro-targets’) or limit (‘anti-targets’) the activity of kinase inhibitors within models of KRAS variant metastatic colorectal cancer, and then harness this information to predict and synthesize novel compounds optimized towards whole animal networks.

PI_NAMEs: CAGAN, ROSS LEIGH;DAR, ARVIN  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: absorption;analog;Animals;Apoptosis;aurora kinase A;Benchmarking;Biological Assay;Biology;BRAF gene;Cancer Etiology;Cancer Model;Cells;Cessation of life;chemical genetics;Chemical Modifier;Chemicals;Chemistry;Clinical;colon cancer cell line;colon cancer patients;Colorectal Cancer;comparative;Complex;Computer Models;cost;Data;design;Development;Diagnosis;Disease;Drosophila genus;Drug Design;drug development;Drug Kinetics;Epidermal Growth Factor Receptor;Excretory function;FDA approved;fly;gastrointestinal;Genes;Genetic;genetic analysis;genetic approach;Genetic Screening;Goals;Half-Life;Human;Immunotherapy;improved;In Vitro;in vivo;inhibitor;innovation;insight;interdisciplinary approach;kinase inhibitor;KRAS2 gene;Lead;Libraries;Malignant Neoplasms;Maps;Mediating;Metabolism;metastatic colorectal;Modeling;Modification;Monomeric GTP-Binding Proteins;mortality;Mus;mutant;Nature;Neoplasm Metastasis;neoplastic cell;network attack;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;patient derived xenograft model;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phosphotransferases;Primary carcinoma of the liver cells;Property;Protein Isoforms;RAF1 gene;Refractory;Series;side effect;Signal Transduction;small molecule;structural biology;Structure;Structure-Activity Relationship;Survival Rate;Testing;Therapeutic;Therapeutic Index;Time;Toxic effect;TP53 gene;Treatment Efficacy;tumor;tumor growth;tumor initiation;United States;Variant;Xenograft Model;Xenograft procedure

PROJECT_TITLE: A Chemical Genetic Approach to Exploring Novel Therapeutic Space for Colorectal Cancer

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative: Molecular Mechanisms of Adjuvant Triplet Combinations The next frontier in adjuvant combination research is to identify and characterize higher-order combinations of adjuvants which can mimic the effects of the most potent live attenuated vaccines and be used in new vaccine formulations against infection. In this project, we will dissect the molecular mechanisms through which two newly identified adjuvant triplets impact cellular, tissue, and whole-organism processes to yield long-term protective immunity.

PI_NAMEs: CHEVRIER, NICOLAS  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Adjuvant;Agonist;Attenuated;Attenuated Vaccines;CD8-Positive T-Lymphocytes;Cell Communication;Cell membrane;cell type;Cells;Cellular immunotherapy;Chromatin;Coculture Techniques;combinatorial;comparative;Complex;Data;Data Science;Decision Making;Dendritic Cells;DNA-Protein Interaction;draining lymph node;ds-DNA;experimental study;extracellular;frontier;Future;gene regulatory network;Genetic;Genetic Transcription;Genomics;Human;Image;Immune;immune modulating agents;Immune response;Immune system;Immunity;Immunology;improved;In Vitro;Infection;innovation;insight;lymph nodes;Measures;microbial;Modeling;Modified Vaccinia Virus Ankara;Molecular;mouse model;multimodality;Mus;Natural Immunity;novel vaccines;Organism;Output;pathogen;Pathway interactions;Phosphorylation;Phosphotransferases;Play;Population;Poxviridae Infections;Process;Property;protective effect;Protein Biosynthesis;protein complex;Protein Secretion;Proteins;Proteome;Proteomics;rational design;receptor;Regulation;Research;response;sensor;Shapes;Signal Transduction;Site;Skin;statistics;Surface;T cell response;T memory cell;T-Lymphocyte;Testing;Tissues;Toll-like receptors;Triplet Multiple Birth;tumor;Vaccination;Vaccine Design;vaccine formulation;Vaccinia virus;Whole Organism;Work


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE  This application proposes to identify a novel regulatory mechanism by which overexpression of oncoprotein LSD1 facilitates triple negative breast cancer (TNBC) progression. This project is also aimed at utilizing novel LSD1-targeting agents to enhance tumor suppression, augment antitumor immunity, and overcome therapeutic resistance in TNBC. The results from the proposed studies are expected to provide novel mechanistic insight and rationale for effective combination of leading LSD1 inhibitors with standard or immune therapies as new treatment strategies for patients with advanced TNBC.

PI_NAMEs: HUANG, YI  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Ablation;American;Animal Model;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;anti-tumor immune response;Antineoplastic Agents;Automobile Driving;Breast Cancer Cell;Breast Cancer Patient;breast cancer progression;Breast Cancer therapy;Breast Cancer Treatment;Cancer Biology;cancer clinical trial;Cancer Etiology;cancer stem cell;cancer subtypes;cancer therapy;cancer type;CD8-Positive T-Lymphocytes;cell killing;Cessation of life;chemokine;Chemoresistance;chemotherapeutic agent;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;clinical efficacy;clinically relevant;Combination Drug Therapy;Complex;Data;demethylation;Development;DNA;Drug usage;effector T cell;Epigenetic Process;epigenetic silencing;Foundations;genetic corepressor;Genetic Transcription;Genetically Engineered Mouse;HDAC5 gene;histone demethylase;histone modification;Histones;Hypermethylation;immunogenic;Immunotherapy;improved;In Vitro;in vivo;inhibitor;insight;KDM1A gene;Knock-out;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mediating;Molecular;mouse model;Neoplasm Metastasis;novel;novel therapeutic intervention;Oncogenic;Oncoproteins;overexpression;Patient-derived xenograft models of breast cancer;Patients;Post-Translational Protein Processing;pre-clinical;Prognosis;programmed cell death ligand 1;Protein Overexpression;Proteins;Recurrence;Refractory;Regimen;Relapse;Repression;Repressor Proteins;Resistance;Resistance development;response;restraint;Role;stemness;T cell infiltration;targeted agent;targeted treatment;Therapeutic Effect;therapeutic target;therapy resistant;tissue-factor-pathway inhibitor 2;trait;Transcription Repressor;Treatment Efficacy;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;tumor progression;Tumor Suppression;Tumor Suppressor Genes;tumorigenesis;Woman

PROJECT_TITLE: Role of LSD1 in Triple Negative Breast Cancer Development and Therapeutic Response


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_DEPT: BIOCHEMISTRY

PHR: Poly(ADP-ribose) Polymerase 1 (PARP-1) has important roles in DNA damage repair, regulation of gene expression, and cell death signaling. Inhibitors of PARP-1 have emerged as promising therapeutic agents for the treatment of cancer and inflammation. The studies in this proposal will progress our mechanistic understanding of PARP-1 activation and regulation, improve current models of PARP-1 biological functions, advance our understanding of PARP inhibitor mechanism of action, and develop improved PARP inhibitors with potential strong relevance to the cancer clinic.

PI_NAMEs: BLACK, BEN E. (contact);PASCAL, JOHN M

PROJECT_TERMS: Acute;Address;Adenosine Diphosphate Ribose;Alleles;Allosteric Regulation;Apoptotic;Asian population;Behavior;Binding;Binding Sites;Biochemical;Biological Assay;Biological Process;Biology;Biophysics;Black race;brca gene;cancer cell;cancer therapy;Catalysis;Catalytic Domain;Cell Death;Cell Death Signaling Process;cell killing;Cell Survival;Cells;Cellular biology;Chemicals;Chromosomal Rearrangement;Clinic;Clinical;Collaborations;Communication;Complex;Coupled;Crystallography;Defect;design;Deuterium;Development;DNA;DNA Binding;DNA Damage;DNA Repair;DNA Sequence Alteration;DNA strand break;DNA Structure;drug market;Engineering;Enzymes;experimental study;Gene Expression Regulation;genetic variant;Genome;genome integrity;Goals;Health;Histones;homologous recombination;Human;Hydrogen;image translation;imaging approach;Imaging Techniques;improved;Inflammation;innovation;insight;interdisciplinary approach;interest;Knowledge;Location;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Medicine;Methods;Modeling;Modification;Monitor;mouse model;Mus;Nature;neoplastic cell;next generation;novel;Organism;Pathway interactions;Patient-derived xenograft models of breast cancer;Personal Satisfaction;Pharmaceutical Chemistry;Poly Adenosine Diphosphate Ribose;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Polymers;Positioning Attribute;Post-Translational Protein Processing;Process;Production;programs;Property;Protein Dynamics;Proteins;recruit;Regulation;repaired;Research;Research Personnel;response;Risk;Role;Signal Transduction;Site;small molecule;Specificity;Stress;success;targeted cancer therapy;Testing;Therapeutic Agents;Time;tool;Transcriptional Regulation;tumor;tumor progression;tumor xenograft;Variant;virtual;Work

PROJECT_TITLE: Tuning PARP-1 retention and release on DNA breaks

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Primary Health Care;Social Determinants of Health

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Complete and timely colonoscopy after an abnormal stool-based colorectal cancer screening test results in early detection, cancer prevention, and reduction in mortality, but follow-up in safety-net health systems occurs in less than 50% at 6 months. The proposal will implement multi-level approach consisting of a stepped-wedge clinic- level intervention of team-based best practices co-developed with primary and specialty care, a patient-level technology intervention to provide enhanced instructions and navigation to complete diagnostic colonoscopy, and a mixed methods evaluation to explore multi-level factors contributing to intervention outcomes. Developing a solution to this high-risk and diverse population has the potential to translate to other health systems, support patient self-management, and address other patient conditions.

PI_NAMEs: SARKAR, URMIMALA  (contact);SOMSOUK, MA

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Address;Adherence;Adopted;Attention;Awareness;Behavior;California;cancer prevention;care coordination;Caring;Characteristics;Chinese;Clinic;Clinical Services;Colonoscopy;Colorectal Cancer;colorectal cancer prevention;colorectal cancer screening;Communication;Complement;Consolidated Framework for Implementation Research;Consultations;Continuity of Patient Care;cost;COVID-19 pandemic;Death Rate;design;Diagnostic;disparity reduction;Drug abuse;Drug usage;Early Diagnosis;Electronic Health Record;ethnic minority population;Evaluation;Failure;Feces;follow-up;Foundations;Frontline worker;Funding;Gastroenterology;Health;Health behavior;health information technology;health literacy;Health Status;Health system;Healthcare;Healthcare Systems;High Prevalence;high risk;HIV Infections;Home;housing instability;Impairment;implementation determinants;implementation evaluation;implementation framework;implementation outcomes;implementation research;improved;Incidence;Infrastructure;Instruction;Integrated Health Care Systems;Intervention;Interview;Intestines;Language;Low income;Malignant Neoplasms;medical specialties;Methods;Minority Groups;mortality;Outcome;outreach;Patient Education;patient level intervention;patient navigation;Patients;Population Heterogeneity;Positioning Attribute;Primary Care;primary care clinic;primary care provider;Process;programs;Provider;racial minority population;Randomized;Recording of previous events;Reduce health disparities;Reporting;Research;Resources;Risk;safety net;Sampling;San Francisco;Schedule;screening;Self Management;Social support;Spanish;System;Technology;technology intervention;Test Result;Testing;Text Messaging;Time;Translating;Vulnerable Populations;Work

PROJECT_TITLE: IMProving Adherence to Colonoscopy through Teams and Technology (IMPACTT)

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]