ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative The University of Southern California (USC) “Rising STARS” (Scientific Training in Alcohol Research and other Substances) Program in Los Angeles, CA, is a transdisciplinary program in partnership with the neighboring California State University, Los Angeles (CSULA) and Charles R. Drew University (CDU). This unique and innovative two-year educational and research experience program brings together three universities with the goal to train students from underrepresented minority groups in the areas of alcohol and substance use disorders. Graduates of the program will be poised to matriculate into PhD programs at USC and other leading universities in Southern California and across the country that excel in addiction research.

PI_NAMEs: DAVIES, DARYL L (contact)

PROGRAM_OFFICER_NAME: HOLMES, ANGELA L

PROJECT_TERMS: addiction;Address;Admission activity;Affect;alcohol research;alcohol use disorder;Alcohols;apprenticeship;Area;California;career;career development;Certification;Cities;Clinical;Collaborations;Communities;community engagement;Country;Coupled;Creativeness;design;Development;Discipline;Doctor of Philosophy;Education;Education Projects;Educational Models;Educational Status;Environment;experience;Faculty;faculty mentor;flexibility;Foundations;Future;Geography;Goals;graduate school;graduate school preparation;graduate student;Human;improved;Inequality;Infrastructure;innovation;Institution;interdisciplinary collaboration;interest;Interview;Knowledge;Laboratories;Los Angeles;marginalization;matriculation;Medical;medical schools;member;Mentors;Mentorship;Methodology;Minority Enrollment;Minority Groups;minority undergraduate;Mission;next generation;Participant;Pathway interactions;Pharmacy Schools;Policies;polysubstance use;Population Heterogeneity;Postdoctoral Fellow;pre-clinical;Program Sustainability;programs;Public Health;Research;Research Personnel;Research Project Grants;Research Training;Science;Scientist;skill acquisition;skills;Structure;student participation;student training;Students;Substance abuse problem;Substance Use Disorder;success;Talents;Technical Expertise;Training;undergraduate student;Underrepresented Minority;underrepresented minority student;Universities;waiver

PROJECT_TITLE: Rising STARS (Scientific Training in Alcohol Research and other Substances) Program


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: DAVIS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PI_NAMEs: LLOYD, KC KENT (contact)

PROJECT_TERMS: Assessment tool;Biometry;Budgets;Businesses;Cancer Center Support Grant;cancer research center director;Center Core Grants;Charge;Collaborations;Comprehensive Cancer Center;Computers and Advanced Instrumentation;Consultations;cost;cost effective;Development;Doctor of Philosophy;Effectiveness;Ensure;Equipment;Evaluation;expectation;Fees and Charges;Financial Support;Frequencies;Funding;Future;Grant;improved;Individual;Infrastructure;Institution;instrument;Malignant Neoplasms;Marketing;member;Mission;Monitor;neoplasm resource;Occupational activity of managing finances;operation;outreach;Peer Review;Policies;Process;Productivity;Reporting;Research;Research Activity;Research Personnel;Resource Sharing;Resources;Role;satisfaction;Schedule;Services;sound;Surveys;Technology;tool;Wages

PROJECT_TITLE: Shared Resource Management


ADMINISTERING_IC: HD

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Mammalian digit tips are capable of regenerating following amputation, yet the mechanism of this innate process is not well-understood. In the short term, this project stands to dissect the function(s) of newly identified fibroblast subpopulations during digit tip regeneration towards understanding why the digit tip can regenerate but not other parts of the digit or limb. In the long term, this research serves as the foundation for broader mammalian limb regeneration efforts.

PI_NAMEs: LEHOCZKY, JESSICA A (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Adult;Age;Amputation;Biology;blastema;cell type;Cells;Collection;Communities;Connective Tissue;Data;digit regeneration;Digit structure;Disease;Distal;Embryo;Emerging Technologies;epithelial wound;Fibroblasts;Fibrosis;Foundations;Genes;Germ Layers;Goals;Growth;Heterogeneity;Homeostasis;Human;Individual;limb amputation;Limb Development;limb regeneration;Limb structure;Mediating;Mitotic;model organism;Molecular;Monkeys;Mus;National Institute of Child Health and Human Development;Natural regeneration;Pathway interactions;Pattern;Persons;Population;Population Heterogeneity;Process;progenitor;Publishing;regeneration potential;regenerative;Research;Role;Signal Transduction;single-cell RNA sequencing;skeletal stem cell;skeletal tissue;Spatial Distribution;stem cell population;stem cells;Testing;Time;tissue regeneration;Tissues;transdifferentiation;Traumatic injury

PROJECT_TITLE: Cellular plasticity and lineage in mammalian digit tip regeneration

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Vaccine Related

ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative Despite widespread use of a vaccine, infection with the bacterium Bordetella pertussis continues to claim the lives of ~200,000 infants annually worldwide and cause significant morbidity and mortality in developed countries such as the US. To support development of improved vaccines, the current project aims to use biophysical and structural approaches to understand how the “repeat-in-toxin” domain of the adenylate cyclase toxin interacts with neutralizing antibodies and the αMβ2 integrin receptor on mammalian cells and to assess the impact of altering toxin–receptor binding interactions on immune cell responses in vitro and infection in a mouse model. Since there is little structural data on repeat-in-toxin proteins, this project will provide insight into disease caused by B. pertussis and the other >100 known proteins using similar “repeat-in-toxin” domains.

PI_NAMEs: MAYNARD, JENNIFER A;MCLELLAN, JASON SCOTT (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Acylation;Address;Adenylate Cyclase;Adenylate Cyclase Toxin;Anti-Bacterial Agents;Antibodies;Antibody Affinity;Bacteria;Bacterial Adhesins;Bacterial Infections;Bacterial Toxins;Binding;Binding Sites;Biochemical;Biological Assay;Biology;biophysical analysis;Biophysics;Bordetella pertussis;C-terminal;Calcium;Calcium ion;Calmodulin;Cell membrane;Cells;Complex;Consensus;Cryoelectron Microscopy;Cyclic AMP;Cytoplasm;Data;design;Developed Countries;Development;Disease;Elements;Environment;Epitopes;Extracellular Space;Family;Future;genomic data;Goals;Gram-Negative Bacteria;Hemolysin;Immune;Immune system;immunogenicity;improved;In Vitro;Infant;Infection;inhibiting antibody;insight;Integrins;interest;Intoxication;Length;Leukocytes;Lipase;Macrophage-1 Antigen;Mammalian Cell;Mediating;member;Membrane;Methods;Modeling;Molecular;Molecular Conformation;Morbidity - disease rate;mortality;mouse model;Mus;Mutagenesis;N-terminal;neutralizing antibody;novel;novel vaccines;Organism;Outcome;pathogen;Pathogenesis;Pathway interactions;Peptide Hydrolases;Pertussis;Pertussis Toxin;Pertussis Vaccine;Phagocytes;Positioning Attribute;Predisposition;Prevalence;Process;Protein Engineering;protein protein interaction;protein purification;Proteins;rational design;receptor;receptor binding;Research;Resolution;response;Signal Transduction;Site;Species Specificity;Structure;Therapeutic;Toxic effect;Toxin;Vaccine Antigen;Vaccines;Variant;Virulence Factors;Work;X-Ray Crystallography

PROJECT_TITLE: Structure, function and antigenicity of B. pertussis virulence factors

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


PI_NAMEs: LARA, PRIMO N. (contact)

PROJECT_TERMS: Advisory Committees;Area;Cancer Burden;Cancer Center;Cancer Center Support Grant;career development;Catchment Area;Center Core Grants;Clinical;community advisory board;community engagement;Community Outreach;Comprehensive Cancer Center;Education;Ensure;Evaluation;experience;Feedback;Funding;improved;Leadership;Mission;Oncology;operation;organizational structure;outreach;Patient Care;peer;Peer Review;Policies;Process;Records;Research;Resources;response;Science;Strategic Planning;Structure;Training

PROJECT_TITLE: Leadership, Planning, and Evaluation


NIH_SPENDING_CATS: Aging;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases

PI_NAMEs: KIM, EDWARD J (contact)

PROJECT_TERMS: Address;Adherence;Adult;African American population;Age;Asian Americans;Awareness;Budgets;Businesses;California;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Career Mobility;Caring;Center Core Grants;central database;Child;Clinical;Clinical Cancer Center;Clinical Data;Clinical Practice Guideline;Clinical Protocols;Clinical Research;Clinical Research Protocols;Clinical Trials;Collaborations;Comprehensive Cancer Center;Conduct Clinical Trials;Contracts;COVID-19 pandemic;Data;data integrity;data management;data quality;Dedications;Disease;Disparity;Education;Elderly;Ensure;Ethnic Origin;experience;Generations;Good Clinical Practice;Hispanic Populations;Human Resources;improved;Individual;Infrastructure;Institutional Review Boards;Intervention;Job Satisfaction;Latino Population;Life Cycle Stages;life span;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of prostate;Malignant Neoplasms;Mediation;Minority;minority communities;Minority Groups;Monitor;Office Management;operation;participant enrollment;participant safety;patient safety;patient screening;Patients;Pediatric Oncology;pediatric patients;people of color;Performance;Physician Executives;Physicians;Policies;Population;Procedures;Process;protocol development;Protocols documentation;Publications;recruit;Regulation;Reporting;Reproducibility;Research;Research Personnel;risk minimization;Running;Safety;Services;Structure;Time;Toxic effect;Training;Training and Education;Translating;treatment trial;underserved community;United States National Institutes of Health;Universities;Update;Woman;women's clinical trial;Work

PROJECT_TITLE: Clinical Protocol and Data Management


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Our training program aims to produce health services researchers who have the leadership skills and methodologic expertise to inform policy, improve health system performance, and promote better population health outcomes.

PI_NAMEs: TRIVEDI, AMAL N. (contact)

PROGRAM_OFFICER_NAME: CHANLONGBUTRA, AMORNRAT

PROJECT_TITLE: National Research Service Award


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: CHEW, HELEN K (contact)

PROJECT_TERMS: authority;Breast;Cancer Center Support Grant;cancer clinical trial;cancer research center director;Center Core Grants;Central Nervous System;Chest;Clinical Cancer Center;Clinical Protocols;Clinical Research;Clinical Research Protocols;Clinical Trials;Communication;Comprehensive Cancer Center;Data;Development;Disease;Elements;Ensure;Evaluation;gastrointestinal;Genitourinary system;Goals;Guidelines;Head and neck structure;Hematologic Neoplasms;Institution;Institutional Review Boards;Intervention;Malignant Neoplasms;meetings;Monitor;multidisciplinary;Oncology;Patient Monitoring;Patients;Pediatrics;Phase;Process;Protocols documentation;Recommendation;recruit;Reporting;Research;Research Activity;Research Personnel;Resource Allocation;Resources;Review Committee;Safety;Standardization;Support System;System

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research

PI_NAMEs: GANDOUR-EDWARDS, REGINA  (contact)

PROJECT_TERMS: Accreditation;American;anti-cancer research;Basic Science;Benign;biobank;California;Cancer Center Support Grant;Center Core Grants;Certification;Clinical;Clinical Data;Clinical Research;Clinical Sciences;Clinical Trials;Collection;college;Comprehensive Cancer Center;Consultations;Data;Database Management Systems;Ensure;Ethics;experience;Floor;Freezing;Health;Health Insurance Portability and Accountability Act;Histology;Hospitals;Human;Individual;Institutional Review Boards;International;Liquid substance;Malignant - descriptor;Malignant Neoplasms;member;Minority;Monitor;Office for Human Research Protections;Online Systems;Operative Surgical Procedures;Outcomes Research;Paraffin;Pathologic;Pathologist;Pathology;patient derived xenograft model;Procedures;Process;programs;Protocols documentation;Research;Research Personnel;Resource Sharing;sample collection;Secure;Services;Specimen;Standardization;Tissue Banks;Tissue Microarray;Tissues;translational scientist;Universities

PROJECT_TITLE: Biorepository Shared Resource


PI_NAMEs: QI, LIHONG  (contact)

PROJECT_TERMS: Animals;anti-cancer research;Area;Basic Science;Biological Sciences;biomarker discovery;Biometry;Biostatistical Methods;Biostatistics Shared Resource;Breast Cancer Detection;California;Cancer Center Support Grant;Center Core Grants;Clinic;Clinical Research;Clinical Trials;Code;Collaborations;community intervention;Comprehensive Cancer Center;Consultations;Cost effectiveness research;Data;Data Coordinating Center;Data Set;design;Development;Doctor of Philosophy;Education;Electronic Health Record;Fees and Charges;Fostering;Funding;genome wide association study;Goals;high throughput screening;Individual;innovation;Institution;interest;International;Investigator-Initiated Research;Knowledge;large-scale database;Longitudinal Studies;Malignant Neoplasms;meetings;member;Mentors;metabolomics;Methodology;Methods;MicroRNAs;Mission;Molecular;Monitor;neoplasm registry;Pilot Projects;Population Research;predictive marker;Price;Procedures;Process;programs;Proteomics;protocol development;Protocols documentation;Publications;Radiation-Induced Cancer;Reporting;Reproducibility;Research;Research Design;Research Personnel;Research Support;Resource Sharing;Resources;Review Committee;Risk Assessment;risk prediction model;Safety;Sample Size;Screening for cancer;Services;Site;skills;Standard Preparations;Statistical Methods;statistical service;statistics;Subgroup;Survival Analysis;Training;Translational Research;Universities

PROJECT_TITLE: Biostatistics Shared Resource


PI_NAMEs: LAM, KIT S (contact)

PROJECT_TERMS: Amino Acids;anti-cancer research;Antibodies;Basic Science;Biochemical;Biology;cancer cell;Cancer Center Support Grant;Cell Physiology;cellular imaging;Center Core Grants;Chemical Structure;Chemicals;Clinical;clinical translation;Collection;combinatorial;combinatorial chemistry;Comprehensive Cancer Center;Custom;design;Discipline;Doctor of Philosophy;drug discovery;exosome;experience;Goals;High Pressure Liquid Chromatography;Hydrophobicity;imaging agent;In Vitro;in vivo;in vivo evaluation;Individual;Industrialization;instrumentation;Lead;lead optimization;Libraries;Malignant Neoplasms;Mass Spectrum Analysis;meetings;member;Methods;molecular imaging;molecular marker;nanoformulation;nanomicelles;nanotechnology platform;Natural Products;Nature;Organic Synthesis;Pathway interactions;Peptide Nucleic Acids;Peptide Phage Display Library;Peptide Synthesis;Peptides;peptidomimetics;Peptoids;Pharmaceutical Chemistry;Pharmaceutical Preparations;Polyvinyl Alcohol;Process;Proteins;Reagent;Research;Research Personnel;Resource Sharing;Resources;response;Science;Services;small molecule;Source;T-Lymphocyte;Techniques;technology platform;technology training;Time;tool;Translational Research;unnatural amino acids

PROJECT_TITLE: Combinatorial Chemistry and Chemical Biology Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: SHACKLETT, BARBARA L. (contact)

PROJECT_TERMS: anti-cancer research;Apoptosis;Basic Science;Biological Assay;California;Cancer Center Support Grant;Cancer Etiology;cell analyzer;Cell Cycle;Cell Separation;Cells;Center Core Grants;Clone Cells;Color;community center;Comprehensive Cancer Center;Computer software;Consult;Consultations;COVID-19;Cytometry;Data Analyses;design;Development;Doctor of Philosophy;Education;Equipment;exosome;experience;Experimental Designs;experimental study;Feedback;Flow Cytometry;Flow Cytometry Shared Resource;Gene Expression Profiling;Genotype;Group Meetings;Health;Human Resources;Immunologist;Immunophenotyping;Individual;instructor;instrumentation;Interest Group;Laboratories;Leadership;Licensing;Malignant Neoplasms;Manuscripts;member;Neoplasm Metastasis;new technology;novel strategies;Preparation;Principal Component Analysis;Process;Proliferating;Research;Research Personnel;Research Project Grants;Resource Sharing;Scholarship;single cell genomics;Site;Sorting;Students;System;Techniques;Technology;Time;tool;Training;virtual;Work

PROJECT_TITLE: Flow Cytometry Shared Resource


PI_NAMEs: MCPHERSON, JOHN D. (contact)

PROJECT_TERMS: analysis pipeline;Applications Grants;Area;Bioinformatics;Biological Assay;Cancer Center Support Grant;cancer genomics;career;Center Core Grants;ChIP-seq;Clinical;Collaborations;Complex;Comprehensive Cancer Center;Consultations;COVID-19 detection;Data Analyses;data integration;Data Set;detection assay;Development;DNA sequencing;Doctor of Philosophy;Education;Educational workshop;epigenomics;exome sequencing;exosome;experience;Experimental Designs;experimental study;Fostering;Gene Expression Profile;Genome;Genomics;Genomics Shared Resource;Hi-C;Human Genome Project;Individual;instrumentation;Laboratories;Logistics;Manuscripts;member;Mentors;Mentorship;Meta-Analysis;metabolomics;Metagenomics;Methods;MicroRNAs;Molecular;molecular diagnostics;Molecular Profiling;mutation screening;nano-string;next generation sequencing;Outcome;patient derived xenograft model;Pre-Clinical Model;Preparation;Process;Productivity;Proteomics;Protocols documentation;Reagent;Research;Research Personnel;Resource Sharing;Saliva;Sampling;sequencing platform;Serum;Services;single cell sequencing;Source;Specimen;System;Technology;Testing;Tissues;Training;transcriptome sequencing;transcriptomic profiling;translational genomics;tumor DNA;Viral Genome;virtual;Whole Blood;Work

PROJECT_TITLE: Genomics Shared Resource


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative This is a research training program for postdoctoral fellows at Oregon Health & Science University, Portland, Oregon. The proposed program will address an urgent need for cardiovascular scientists who are trained broadly in translational sciences focused on cardiovascular disease. The program will train 30 scientists who will join the ranks of academia and promote cutting-edge research in heart disease.

PI_NAMEs: ALKAYED, NABIL J (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TITLE: Training in Translational Science and Cardiovascular Research

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


PI_NAMEs: CHAUDHARI, ABHIJIT J (contact)

PROJECT_TERMS: Address;anatomic imaging;Animal Cancer Model;Animal Model;Animals;Board Certification;Budgets;Cancer Center Support Grant;cancer imaging;Cancer Model;cancer therapy;Canis familiaris;Center Core Grants;Clinic;companion animal;Comprehensive Cancer Center;Data Analyses;Dedications;design;Diagnosis;Diagnostic;Doctor of Philosophy;Equipment;experience;Experimental Designs;Felis catus;follow-up;Foundations;Functional Imaging;Genomics;Grant;Human;human disease;human model;IACUC;Image;image processing;image translation;imaging biomarker;imaging facilities;imaging modality;imaging probe;imaging science;imaging study;Imaging technology;in vivo;in vivo imaging;Individual;Institutional Review Boards;Magnetic Resonance Imaging;Malignant Neoplasms;Manuscripts;Medical Imaging;member;Molecular;molecular imaging;non-invasive imaging;optical imaging;Outcome;Positron-Emission Tomography;pre-clinical;Preparation;Process;Protocols documentation;quantitative imaging;Radiochemistry;radiologist;Research;Resource Sharing;Resources;Rodent Model;single photon emission computed tomography;targeted imaging;Technology;Therapeutic;tool;Tracer;Training;Translations;Ultrasonography;ultrasound;Validation;X-Ray Computed Tomography

PROJECT_TITLE: In Vivo Translational Imaging Shared Resource


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative: Due to the epidemic of obesity and diabetes, the most common cause of chronic liver disease is a condition known as non-alcoholic steatohepatitis (NASH). My project explores an important impairment in NASH that contributes to disease progression, namely, the failure of immune cells in the liver called macrophages to safely and efficiently dispose of dead liver cells (hepatocytes). By studying how this failure occurs and how it can be fixed, I hope to gain new insights into the mechanisms of NASH and new ideas about how this devastating disease can be treated.

PI_NAMEs: SHI, HONGXUE  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Acceleration;Address;Affect;Apoptotic;Area;career;CD47 gene;CD47-SIRPα;Cells;chronic liver disease;Data;design;Diabetes Mellitus;Disease;Disease Progression;Erinaceidae;Etiology;Failure;FDA approved;Fibrosis;Functional disorder;Hepatic Stellate Cell;Hepatocyte;Human;Immune;Impairment;improved;insight;Knockout Mice;Knowledge;Kupffer Cells;Liver;Liver diseases;Liver Fibrosis;Macrophage;Mediating;Mediator;Mentors;Modeling;mouse model;Mus;nonalcoholic steatohepatitis;novel;Obesity Epidemic;p38 Mitogen Activated Protein Kinase;Pathway interactions;Pharmaceutical Preparations;Phase;Phenotype;Process;programs;Protein Secretion;Proteins;Proteomics;PTPNS1 gene;Publishing;receptor;Repression;Research;Resolution;restoration;Role;single-cell RNA sequencing;Structure;Testing;Text;Therapeutic;Tissues;Training;TREM2 gene;Up-Regulation;uptake;Work

PROJECT_TITLE: Clearance of Dead Hepatocytes by Liver Macrophages in NASH

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: WORCESTER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project narrative. Pulmonary tuberculosis, the disease caused by Mycobacterium tuberculosis, is a threat to global health. This research proposal seeks to understand how the interaction between macrophages and T cells promotes control of the infection.

PI_NAMEs: BEHAR, SAMUEL M (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Address;Affect;Agonist;Alveolar Macrophages;antagonist;Anti-Bacterial Agents;Antimycobacterial Agents;ATP binding cassette transporter 1;Autophagocytosis;Bacteria;Biological Markers;Biological Process;Biology;CD14 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Compartmentation;Cell Nucleus;Cell surface;cell type;Cells;Collaborations;Communicable Diseases;Containment;Cyclic ADP-Ribose;Data;Dendritic Cells;Disease;effector T cell;Endocytic Vesicle;Environment;Event;Foundations;global health;Goals;Growth;Host Defense;Human;Immunity;Immunodeficient Mouse;improved;In Vitro;in vivo;Infection;Infection Control;Inflammatory;Inflammatory Response;interest;Interferon Type II;interstitial;Investigation;ITGAX gene;Knockout Mice;Lung;Lysosomes;Macrophage;Mediator;Modeling;Molecular;Monitor;monocyte;Mus;Mycobacterium tuberculosis;NAADP;Nitric Oxide;novel;Pathway interactions;peripheral blood;Persons;Phagocytosis;Phagolysosome;podoplanin;Population;Production;programs;Pulmonary Tuberculosis;recruit;Research Proposals;Resistance;Role;Scheme;Second Messenger Systems;Signal Transduction;T-Cell Activation;T-Lymphocyte;therapeutic target;Tuberculosis;tuberculosis immunity

PROJECT_TITLE: The role of CD38 in immunity to tuberculosis

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


NIH_SPENDING_CATS: Biotechnology;Cancer;Precision Medicine

PI_NAMEs: YU, AIMING  (contact)

PROJECT_TERMS: Animal Model;antagonist;anti-cancer;anti-cancer research;Area;assay development;Basic Science;Biological Assay;Biological Markers;biomarker identification;biomarker signature;Biomedical Engineering;Cancer Biology;Cancer Center Support Grant;cancer clinical trial;cancer pharmacology;Cell Line;Cells;Center Core Grants;Characteristics;CLIA certified;Clinic;Clinical;Clinical Drug Development;clinical investigation;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Network;clinically relevant;Collaborations;Collection;Comprehensive Cancer Center;Conduct Clinical Trials;Confidentiality of Patient Information;Data Analyses;Doctor of Philosophy;Drug Combinations;Drug Interactions;Drug Kinetics;drug metabolism;experience;first-in-human;Funding;Genus Hippocampus;Health Insurance Portability and Accountability Act;Individual;Investigational Therapies;Laboratories;Lead;Malignant Neoplasms;Metabolic;MicroRNAs;Modeling;Molecular;molecular diagnostics;Molecular Profiling;National Cancer Institute;National Clinical Trials Network;New Agents;novel therapeutic intervention;novel therapeutics;Organoids;participant enrollment;patient derived xenograft model;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacologic Actions;Pharmacology Shared Resource;Phase I Clinical Trials;pre-clinical;pre-clinical assessment;Pre-Clinical Model;precision medicine;Precision therapeutics;Process;Property;protocol development;Regimen;Regulation;Research;Research Design;Research Personnel;Resource Sharing;Resources;sample collection;Sampling;Services;Site;skills;Small Interfering RNA;Specimen;Specimen Handling;Study models;Technical Expertise;Technology;Testing;Translating;Translational Research;tumor metabolism;Universities;virtual;Work;Xenograft procedure

PROJECT_TITLE: Molecular Pharmacology Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

PI_NAMEs: LLOYD, KC KENT (contact)

PROJECT_TERMS: anti-cancer research;assisted reproduction;Autopsy;Bariatrics;Basic Cancer Research;Biology;blastocyst;Breeding;Cancer Center Support Grant;Cancer Model;Center Core Grants;Clinical Pathology;Cohort Studies;Comprehensive Cancer Center;congenic;Consultations;cost effectiveness;CRISPR/Cas technology;Cryopreservation;Dedications;Derivation procedure;digital;disease model;disorder prevention;Doctor of Philosophy;Embryo;embryonic stem cell;Ensure;experience;Funding;Gene Targeting;Generations;Genome;genome editing;Genotype;Germ;germ free condition;Gnotobiotic;Goals;Health;Health Insurance Portability and Accountability Act;homologous recombination;Image;in vivo;Individual;Infrastructure;interest;Intracytoplasmic Sperm Injections;Knock-in Mouse;Knock-out;Maintenance;Malignant Neoplasms;member;Microinjections;Microscopic;Microsurgery;Mission;Monitor;mouse model;Mus;Mutagenesis;Mutant Strains Mice;Operative Surgical Procedures;Pathology;patient derived xenograft model;Phenotype;Point Mutation;preclinical study;Preparation;Process;Production;Productivity;professor;programs;Quality Control;Reproducibility;Reproductive Techniques;Research;Research Personnel;Research Support;Resource Sharing;Resources;response;Resuscitation;Scanning;screening;Services;Slide;Speed;Stains;Technology;Telemetry;tissue preparation;Training;transcriptome;Transgenic Organisms;translational cancer research;Vendor

PROJECT_TITLE: Mouse Biology Shared Resource


ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE In 2013, Boston Medical Center, New England’s largest safety-net hospital, established an interdisciplinary predoctoral and postdoctoral AHRQ fellowship program and have successfully trained Family Medicine, General Internal Medicine, Pediatrics, and Public Health researchers to improve health care delivery for underserved patients. This competitive renewal will expand our program by including trainees from the Department of Surgery, and add social determinants of health, health equity, and community engagement didactic and experiential learning opportunities. The four objectives of our program are to: (1) Recruit and retain high-quality, diverse candidates interested in research careers focused on improving health care quality, access, and delivery for underserved patients; (2) Provide predoctoral and postdoctoral fellows with comprehensive research training; (3) Produce graduates who will conduct research on health care quality, access and delivery for low-income populations and whose research translates to systems change; and (4) Evaluate our program for continuous improvement.

PI_NAMEs: LAROCHELLE, MARC  (contact)

PROJECT_TITLE: Training in Health Services Research for Vulnerable Populations


NIH_SPENDING_CATS: Bioengineering;Cardiovascular

ORG_CITY: ATLANTA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative This interdisciplinary program in Cardiovascular Biomechanics at Emory University and Georgia Tech (CBT@EmTech) will train the next generation of biomedical engineers to study how biomechanics affects cardiovascular diseases. Trainees will receive formal coursework, research training, and professional development that will enable them to apply an integration of engineering, vascular biology, data sciences, and biosciences to unsolved problems in cardiovascular medicine. We expect these trainees to be thought leaders in the diagnosis and treatment of cardiovascular disease.

PI_NAMEs: DASI, LAKSHMI PRASAD;JO, HANJOONG  (contact);OSHINSKI, JOHN N;PANITCH, ALYSSA

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TITLE: CBT@EmTech - CardioVascular Biomechanics Training Program at Emory and GaTech


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Regenerative Medicine

ORG_CITY: GAINESVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Relevance to Public Health Natural biopolymers are gaining traction as components of surgical materials as noted by the 2019 Food and Drug Administration approval silk fibroin's use in tissue reconstruction-based implants. Silk fibroin, a long biopolymer often isolated from the cocoons of the domesticated silkworm, has many applications, but it is hard to modify to fit specific structural or biological needs, leading us to explore a new silk- producing moth called the Indianmeal moth. We will advance the opportunities for use of silk proteins in biomedical applications by tailoring the sequence and structure of the silk fiber produced by the Indianmeal moth through control over environmental conditions (humidity, temperature, pathogens) and control over the actual biopolymer sequence using targeted genetic engineering strategies, highlighting a new way to leverage the biodiversity of insect species for healthcare applications.

PI_NAMEs: STOPPEL, WHITNEY L (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Address;Agriculture;Amino Acid Sequence;aqueous;Award;Bacteria;Binding;Biochemical;Biodiversity;Biological;Biophysics;Biopolymers;Bombyx;Bombyx mori;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;design;Embryo;Fiber;Fibroins;Future;Gene Modified;Genetic Engineering;Goals;Growth Factor;Healthcare;Human;Humidity;Immune response;Implant;implantation;improved;In Vitro;in vivo;Injections;Insecta;Interruption;Investigation;Length;Lepidoptera;Life Cycle Stages;Mammalian Cell;manufacture;mechanotransduction;Medical Device;Medicine;Modification;Moths;Muscle rehabilitation;Natural regeneration;Outcome;pathogen;Peptides;Pharmacologic Substance;Phase;Phenotype;Polymers;Population;Process;Production;protein aminoacid sequence;Proteins;Public Health;Pupa;Research;Research Personnel;scale up;Silk;Site;Solvents;Stimulus;Structure;success;surgery material;Temperature;Tissue Engineering;tissue reconstruction;tool;Traction;Transcriptional Regulation;Translations;United States Food and Drug Administration;Work

PROJECT_TITLE: Leveraging biodiversity and utilizing genetic engineering to expand the structure and function of silk fibroin biopolymers for biomedical applications


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: PHYSICS

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as chromatin motion, often overlooked, is a prerequisite feature of DNA translocations. This project is pertinent to the mission of NIGMS as it aims to develop tools to monitor the DNA motion, to understand the physical properties of the chromatin, and to investigate its role in fundamental biological functions.

PI_NAMEs: LIU, JING  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Biological Process;Cell Nucleus;Chromatin;chromatin remodeling;chromosomal location;Computer software;Data;Data Science;Disease;DNA;DNA Damage;Epigenetic Process;epigenetic regulation;Etiology;Gene Expression;Gene Expression Profile;Genetic Transcription;Genome;Goals;imaging informatics;imaging system;innovation;interdisciplinary approach;Interphase;Investigation;Link;Maps;mathematical model;Measures;Mission;Modification;Monitor;Motion;nanometer resolution;nanoscale;National Institute of General Medical Sciences;Phenotype;physical property;Public Health;Reaction;Research;Resolution;Role;single molecule;therapeutic development;Therapeutic Intervention;Three-Dimensional Imaging;tool;transcription factor;Untranslated RNA

PROJECT_TITLE: Monitoring the three-dimensional motion of chromatin at single molecule resolution

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision

ORG_CITY: DURHAM

ORG_NAME: UNIVERSITY OF NEW HAMPSHIRE

ORG_STATE: NH

PHR: Recognizing the need to address wide-spread metabolic (e.g. diabetes), growth (e.g. cancer), neurological, and visual disorders, this research will elucidate the molecular basis of interactions between peptides/small-molecules and signaling proteins that participate in protein-protein interactions. Characterization of these binding modes and mechanisms will accelerate the pace of discovery for designing novel therapeutic approaches targeting these proteins.

PI_NAMEs: VASHISTH, HARISH  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Acceleration;Address;Agonist;Allosteric Site;antagonist;Binding;Cell Surface Receptors;computer studies;Cone;Data;design;Diabetes Mellitus;Extracellular Domain;Family;G-Protein-Coupled Receptors;genetic regulatory protein;Growth;Growth Factor;GTP-Binding Protein alpha Subunits;GTP-Binding Proteins;Hormones;Insulin;insulin-like peptide;Malignant Neoplasms;Mediator;Metabolic;mimetics;Modeling;Molecular;Nervous System Disorder;novel;novel therapeutic intervention;Pathway interactions;peptide analog;Peptides;peptidomimetics;Protein Family;protein protein interaction;Proteins;receptor;Research;RGS Proteins;Signal Transduction;Signaling Protein;small molecule;small molecule inhibitor;Snail Venoms;Therapeutic Intervention;Viral;Vision Disorders;Visual

PROJECT_TITLE: Peptides and Small-molecules Targeting Signaling Proteins and Protein-Protein Interfaces

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Infertility;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LA JOLLA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative Male infertility is extremely common (affecting >100 million men world-wide) but in most cases the underlying mechanism is not known and there are no direct treatment options. This application is focused on spermatogonial stem cells (SSCs), which hold promise for correcting many cases of male infertility. The experiments proposed in this application are designed to understand fundamental mechanisms underlying both SSC development and expansion, as key steps towards the goal of developing SSC therapy for treating infertility.

PI_NAMEs: TAN, KUN ;WILKINSON, MILES FROME (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Adult;Affect;Automobile Driving;cancer therapy;Cell Differentiation process;Cell Physiology;Cell Transplantation;cell type;Cells;Characteristics;chemotherapy;clinical application;Data;Defect;design;Development;Diagnosis;Disease;Event;Exhibits;experimental study;Feedback;Fertility;follow-up;Gene Targeting;Generations;Genes;Genetic;Germ Cells;glial cell-line derived neurotrophic factor;Goals;Homeobox;Human;human male;In Vitro;in vivo;Infertility;insight;interest;Knock-out;Knockout Mice;Male Infertility;men;Modeling;Molecular;Mus;overexpression;Patients;Pharmaceutical Preparations;Phenotype;precursor cell;Process;progenitor;Proliferating;Proteins;Regulation;Reporting;response;Role;self renewing cell;single-cell RNA sequencing;Spermatogenesis;spermatogenic epithelium structure;Spermatogonia;Stem Cell Development;stem cell expansion;stem cell self renewal;stem cell therapy;stem cells;Testing;transcription factor;Transcription Factor 3;Transcriptional Regulation;Translating;Undifferentiated

PROJECT_TITLE: Spermatogonial Stem Cell Establishment and Regulation

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: CAMBRIDGE

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

PHR: Project Narrative Periodontal diseases are common chronic inflammatory disease, afflicting up to 50% of the adult population in the United States and associated with systemic diseases, such as rheumatoid arthritis, cardiovascular disease, and Alzheimer’s disease. Annual costs for the prevention and treatment of periodontal diseases are over $14 billion. The proliferation of anaerobic bacteria in the subgingival biofilm microbiome is central to disease progression, with Porphyromonas gingivalis being implicated as one of the primary bacterial pathogens. We are studying how the amino acid L-arginine, a central player in immune regulation, modulates the physiological state and expression of virulence determinants in P. gingivalis.

PI_NAMEs: DAVEY, MARY ELLEN (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Adult;Affect;Affinity;Agar;Alzheimer's Disease;Amino Acids;Anabolism;Anaerobic Bacteria;appendage;Arginine;Arginine deiminase;Bacteria;Biochemical;Biogenesis;Biological Assay;Carboxypeptidase;Cardiovascular Diseases;Caspase;Cells;ChIP-seq;chronic inflammatory disease;Clinical;Communities;Complex;cost;Cues;Data;Development;differential expression;Disease;Disease Progression;dysbiosis;Epithelium;Equilibrium;Excision;extracellular;Genes;genetic regulatory protein;Germ-Free;gingipain;Gingival Crevicular Fluid;Goals;Growth;Homeostasis;host microbiome;host-associated microbial communities;Human;Hydration status;Image;Immune response;immunoregulation;Indigenous;Infection;Inflammatory;inflammatory bone loss;Knowledge;Laboratories;Larva;Life;Life Style;Link;Lipoproteins;Mediating;Membrane;Metabolism;metabolomics;Methods;Microbial Biofilms;microbial community;microbiome;microbiota;migration;Modeling;Molecular;Monitor;Moths;Motility;Movement;Mus;mutant;Nutritional;oral anaerobes;Oral cavity;oral microbiome;oral pathogen;palmitoylation;pathogen;pathogenic bacteria;Pathogenicity;Pathology;Peptide Hydrolases;Peptides;Periodontal Diseases;Periodontal Infection;Periodontitis;Phenotype;Physiological;Physiology;Pilum;Polyamines;Population;Porphyromonas gingivalis;Prevention;programs;Proliferating;Protocols documentation;Regulation;Regulon;Reporting;Research;response;Rheumatoid Arthritis;sensor;Signal Transduction;Slide;subgingival biofilm;Surface;Surface Tension;System;Systemic disease;targeted treatment;Testing;therapeutic development;Time;transcriptome sequencing;transcriptomics;transmission process;United States;uptake;Urocanate Hydratase;Vesicle;Virulence;Waxes

PROJECT_TITLE: L-Arg availability affects the physiological state of porphyromonas gingivalis.


NIH_SPENDING_CATS: Genetics

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Our research aims to understand how proteins, specifically potassium channels, are made and fold to function correctly. Defects in these processes lead to pathology and even death. Our discoveries will identify the problems when proteins do not fold properly and will enable therapeutic drugs to be designed to combat these fundamental causes of disease.

PI_NAMEs: DEUTSCH, CAROL J (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TITLE: Biogenesis of voltage-gated K+ channels

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Sex steroids regulate body weight and energy homeostasis, but central mechanisms underlying these effects are not fully elucidated. This research proposal aims to establish the medial amygdala as an integrating center for neurosteroid testosterone/estrogen signaling in energy homeostasis. Results from this work will provide some important clues regarding one of the fundamental mechanisms contributing to body weight control.

PI_NAMEs: XU, PINGWEN  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: adenovirus mediated delivery;Adrenal Glands;Adrenalectomy;age related;Agonist;Amygdaloid structure;androgen deprivation therapy;Androgen Receptor;androgenic;Androgens;Aromatase;Binding;Body mass index;Body Temperature;Body Weight;Body Weight decreased;Brain;Brain region;Castration;Central Nervous System;Coupled;Data;Development;Diet;diet-induced obesity;Dose;Electrophysiology (science);energy balance;Energy Metabolism;Enzymes;Epidemic;ESR1 gene;Estradiol;Estrogen Receptor 2;estrogenic;Estrogens;Female;Gonadal Steroid Hormones;High Fat Diet;Homeostasis;Hormones;Human;Hypogonadism;Individual;Injections;Knockout Mice;Ligands;LoxP-flanked allele;male;male sex hormones;Medial;Mediating;men;Metabolic;Metabolic Pathway;Metabolic syndrome;Mouse Strains;Mus;Mutant Strains Mice;Mutation;neural;neural circuit;Neurons;neurosteroids;novel;Obesity;Obesity associated disease;obesity development;obesity prevention;Ovariectomy;overexpression;Phenotype;Physical activity;Physical Stimulation;Physiological;Play;prevent;receptor;Receptor Signaling;Regulation;Reporting;Research;Research Proposals;Role;sex;side effect;Signal Pathway;Signal Transduction;Stanolone;Steroids;System;Testing;Testosterone;Weight Gain;weight maintenance;Weight maintenance regimen;Work

PROJECT_TITLE: Testosterone and estrogen signaling pathways in the medial amygdala interact to control energy homeostasis

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: SAN DIEGO

ORG_DEPT: CHEMISTRY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Project Narrative  Sufficient drug accumulation into infected cells is critical to kill intracellular pathogens; however, there is currently a lack of methods to quantify intracellular drug levels in the context of infection. In this project, we will demonstrate that single cell mass spectrometry can be used to quantify intracellular drug levels and intracellular drug metabolism, linking them to pathogen clearance failure and thus to treatment failure. The proposed research is relevant to public health and the NIH’s mission because it will develop a new technique to quantify intracellular antimicrobial drug levels, enabling insight into mechanisms of infectious disease treatment failure and the development of new solutions to address this critical health issue.

PI_NAMEs: MCCALL, LAURA-ISOBEL  (contact);YANG, ZHIBO

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: 2019-nCoV;Address;analytical method;Anti-Bacterial Agents;anti-microbial drug;Anti-viral Agents;antimicrobial;Antineoplastic Agents;Antiparasitic Agents;Bacterial Infections;Benznidazole;Biohazardous Substance;Biological;Biological Availability;Cells;Cellular Metabolic Process;Cessation of life;Characteristics;clinical implementation;Communicable Diseases;Communities;Development;Dose;drug development;Drug Kinetics;drug metabolism;Drug resistance;drug testing;efflux pump;Ensure;Environment;Failure;fexinidazole;Goals;Health;Heterogeneity;improved;In Vitro;Individual;Infection;infectious disease treatment;innovation;insight;instrument;Link;Malignant Neoplasms;Mass Spectrum Analysis;Metabolic;metabolic abnormality assessment;Metabolism;Methodology;Methods;Microbial Drug Resistance;Mission;mortality;neoplastic cell;Nifurtimox;novel;Parasites;Parasitic infection;Parents;pathogen;Penetration;Pharmaceutical Preparations;Prodrugs;Public Health;Research;Role;Spectrometry;Streptococcus pyogenes;success;System;Techniques;Technology;technology/technique;Testing;Tissues;Treatment Failure;Trypanosoma cruzi;United States National Institutes of Health;uptake;Virus Diseases;Work

PROJECT_TITLE: Novel single-cell mass spectrometry methods to assess the role of intracellular drug concentration and metabolism in antimicrobial treatment failure

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Clinical Research;Prevention

PHR: Narrative: Prior alloimmunization places patients at risk of developing potentially fatal delayed hemolytic transfusion reactions (DTHRs) following red blood cell (RBC) alloantigen re-exposure. Despite the severity of these transfusion reactions, very little is known about the immune factors that govern anamnestic RBC alloantibody formation. This study will leverage clinical and pre-clinical approaches to define the immune factors responsible for the development of anamnestic antibody formation with the long-term goal of identifying key targets that may prevent or reduce alloantibody formation that led to DHTRs.

PI_NAMEs: STOWELL, SEAN R (contact)

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: Acceleration;Alloantigen;Alloimmunization;Antibodies;Antibody Formation;Antibody Response;Antigens;Automobile Driving;B-Cell Development;B-Lymphocytes;CD4 Positive T Lymphocytes;Cell Count;chemokine receptor;Clinical;Clinical Research;Critical Pathways;Data;Dendritic cell activation;Dendritic Cells;Development;Disease;Enrollment;Erythrocyte Transfusion;Erythrocytes;Event;Excision;Fetus;Goals;Helper-Inducer T-Lymphocyte;human subject;Immune;Immunologic Factors;insight;Interferon Type I;interferon-alpha B;Isoantibodies;Mediating;mortality;Mus;Newborn Infant;Pathway interactions;Patients;Population;pre-clinical;Pre-Clinical Model;preclinical study;prevent;Prevention;Process;Reaction;Receptor Cell;receptor expression;Receptor Signaling;response;Risk;Role;Severities;Sickle Cell Anemia;stem;Testing;Toll-like receptors;Transfusion

PROJECT_TITLE: Examining Immune Circuits Responsible for Anamnestic RBC Alloimmunization

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Cancer

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The Training Program in the Immunobiology and Cell Biology of Cancer at Washington University in St. Louis seeks continued support for research training of talented doctors and scientists who wish to pursue careers in discovering basic principles of cancer immunobiology and/or applying their knowledge to the development of novel and more effective cancer treatments. The Program faculty are highly accomplished medical scientists performing state-of-the-art cancer related research in a premier world-class medical research institution with special emphasis being placed on cancer immunology and development of novel cancer therapies. This T32 program has made and continues to make significant contributions to developing the careers of talented young scientists with an interest in the rapidly advancing fields of cancer immunology and immunotherapy.

PI_NAMEs: SCHREIBER, ROBERT DAVID (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: TRAINING IN THE IMMUNOBIOLOGY AND MOLECULAR CELL BIOLOGY OF CANCER

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Biotechnology;Natural Products

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

PHR: Narrative The proposed research will study enzymatic reactions that catalyze nitric oxide-dependent reactions. These enzymes will help understand the onset of neurodegenerative diseases, antibiotic biosynthesis by bacteria, and how infectious bacteria survive the human immune response. In addition, this work will enable the engineering of enzymes to make synthesis of human therapeutics less costly, more efficient, and less harmful to the environment.

PI_NAMEs: CARANTO, JONATHAN D (contact)

PROJECT_TERMS: Anabolism;Antibiotics;Bacteria;Biochemical Reaction;Biochemistry;Biological;Biological Markers;cell injury;Cells;Chemistry;cost;Cytochrome a;Cytochrome P450;Data;Engineering;Environment;Enzymes;Genus Mycobacterium;Goals;Health;Heme;Hemerythrin;Hispanic-serving Institution;Homologous Gene;Human;Hydroxylation;Immune response;insight;Ions;Ligand Binding;Ligands;Mediating;metalloenzyme;Metals;mycobacterial;Mycobacterium tuberculosis;Natural Products;Neurodegenerative Disorders;Nitrates;nitration;Nitric Oxide;Nitrites;Nitrogen;nitrosative stress;novel;oxidation;pathogenic bacteria;Pathogenicity;Pathway interactions;Peroxonitrite;programs;Protein Engineering;protein function;Proteins;Reaction;Reporting;Research;Role;Site;Structure;Structure-Activity Relationship;Therapeutic;Training Programs;Tryptophan;Tyrosine;Virulence;Vision;Work

PROJECT_TITLE: Mechanisms of novel biological nitrogen chemistries


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Pediatric;Transplantation;Urologic Diseases

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Hemorrhagic cystitis or bleeding from the bladder occurs in up to 25% of bone marrow transplant recipients and is associated with BK polyomavirus infection, although the mechanisms of bladder injury are not known. The proposed research project will test the hypothesis that the risk of hemorrhagic cystitis in patients with BK polyomavirus replication in the urine is a function of the viral subtype and the host response to the virus. This research will provide the foundation for future clinical trials testing if strategies such as the infusion of exogenous T cells can prevent or treat BK polyomavirus-associated disease and subsequently decrease morbidity and mortality for transplant patients.

PI_NAMEs: BLACKARD, JASON T;LASKIN, BENJAMIN LEWIS (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: Age;Allogenic;Anti-viral Agents;Anti-viral Therapy;Award;BK Virus;Bladder;Bladder Injury;Blood specimen;Blood Transfusion;Bone Marrow Transplantation;Case/Control Studies;Cell Therapy;chemotherapy;Chemotherapy-Oncologic Procedure;Child;Childhood;Clinical;Clinical Data;Clinical Treatment;Clinical Trials;cohort;Combination Drug Therapy;Complication;conditioning;cost;Cox Models;Cystitis;Data;Disease;Engraftment;Enrollment;Evaluation;exosome;Foundations;Future;Gender;Gene Deletion;Genes;Genetic Polymorphism;Genetic Variation;Genome;Glycoproteins;Goals;graft vs host disease;Hematopoietic Stem Cell Transplantation;Hemorrhage;high risk;HIV/HCV;Hospital Costs;Hospitalization;immune reconstitution;Immune response;improved;Incidence;Individual;Infection;Infusion procedures;Injury;Inpatients;Knowledge;Length;Length of Stay;Medical center;Membrane;Modeling;Molecular;Morbidity - disease rate;mortality;mortality risk;Mutation;neutrophil;next generation sequencing;novel;novel therapeutics;Obstruction;Outcome;Pain;Participant;patient oriented;Patient-Focused Outcomes;Patients;Pediatric Hospitals;Persons;Philadelphia;Polyomavirus Infections;Population;predictive modeling;prevent;Prevention strategy;Procedures;prospective;Proteins;Proteomics;Questionnaires;Research;Research Project Grants;Resolution;response;Risk;RNA;ROC Curve;Sample Size;Sampling;Specificity;Supportive care;T-Lymphocyte;targeted treatment;Testing;Time;transcriptome sequencing;transcriptomics;Transfusion;Transplant Recipients;treatment strategy;urinary;urinary tract obstruction;Urination;Urine;Validation;Variant;Vesicle;Viral;Viral Physiology;Virulence;Virus;virus genetics;young adult

PROJECT_TITLE: Viral and host predictors of BK polyomavirus associated hemorrhagic cystitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(90)]


NIH_SPENDING_CATS: Sleep Research

ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Sleep disorders are common in the general population, with almost one hundred sleep disorders described to date (e.g. sleep apnea, narcolepsy, advanced and delayed sleep phase syndromes), making it imperative to understand this behavior in order to alleviate sleep-related health problems. Estimated 40-70% of people are sleep deprived because they either cannot sleep (have insomnia), or do not sleep (lifestyle limitations and choices). The fly has been at the vanguard of efforts to understand many previously mysterious biological phenomena and there is every reason to believe that this role will be revisited in investigating sleep (for instance, factors that are linked to familial sleep disorders in humans – Period and Casein Kinase 1- had their homologues discovered and first characterized in Drosophila).

PI_NAMEs: ROGULJA, DRAGANA  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Animals;Antioxidants;Behavior;Biological Phenomena;casein kinase I;Cause of Death;Cell Death;cell injury;cell type;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chronic;Cognitive;Data;Delayed Sleep Phase Syndrome;design;Disease;Drosophila genus;Economic Burden;Epidemic;experience;experimental study;fly;Free Radicals;General Population;Goals;Health;Homologous Gene;Human;Immune response;Impairment;Intestines;Knowledge;Large Intestine;Lead;Life;Life Style;Link;Longevity;Malignant Neoplasms;Mammals;Mental disorders;model organism;Molecular;Mus;Narcolepsy;nutrient absorption;Organ;oxidation;oxidative damage;Oxidative Stress;Oxygen;Pathway interactions;Persons;premature;prevent;Process;Production;Property;Public Health;Reactive Oxygen Species;Role;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep Disorders;Sleeplessness;Small Intestines;Societies;Source;Specificity;Testing;Tissues;tool;Visit;Work

PROJECT_TITLE: Understanding the link between sleep deprivation and oxidative stress

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Biotechnology;Brain Disorders;Clinical Research;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Narrative The “induced pluripotent stem cell (iPSC)” technology is a promising method that can enable personalized autologous cell therapy of Parkinson’s disease (PD) and other degenerative human diseases. To realize the potential of using iPSCs in personalized cell-based therapy for PD, based on our promising pre-clinical as well as clinical studies, we propose to further improve the safety and efficacy of reprogramming and in vitro differentiation technologies. This proposal will provide a standardized method for generating and characterizing clinical grade human iPSCs and transplantable dopamine cells, leading to a platform that will enable personalized cell therapy for PD patients regardless of their genetic backgrounds.

PI_NAMEs: KIM, KWANG-SOO  (contact);KONG, SEK WON

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: Address;Affect;aging population;Allogenic;Alzheimer's Disease;Animal Model;Autologous;Autologous Transplantation;behavior test;Behavioral;Brain;Cell Differentiation process;Cell Fate Control;Cell Line;cell replacement therapy;Cell Therapy;Cell Transplantation;cell type;Cells;Characteristics;Chemicals;Clinical;clinical implementation;Clinical Research;Corpus striatum structure;cost effective;Development;differentiation in vitro;DNA;Dopamine;dopaminergic neuron;Embryo;epigenomics;Ethics;fetal;Fetus;first-in-human;Genetic;genome integrity;Goals;Graft Survival;Harvest;Human;human disease;human embryonic stem cell;human induced pluripotent stem cells;human old age (65+);human pluripotent stem cell;humanized mouse;Immune response;Immunologic Tests;Immunosuppression;improved;In Vitro;in vivo;in vivo evaluation;Individual;individual variation;induced pluripotent stem cell;induced pluripotent stem cell technology;Lesion;Medical;Messenger RNA;Metabolic;Metabolic Control;Metabolism;Methods;MicroRNAs;Midbrain structure;Molecular;Motor;motor disorder;motor symptom;mouse model;mRNA delivery;Mus;neural;Neurodegenerative Disorders;Neurons;neurosurgery;novel;Nude Rats;open label;Outcome;Oxidopamine;Parkinson Disease;Pathologic;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pharmaceutical Preparations;Physiological;Population;pre-clinical;Production;progenitor;promoter;Property;Protocols documentation;prototype;Regimen;reinnervation;Rodent Model;Safety;SIRT1 gene;Societies;Source;sporadic Parkinson's Disease;Standardization;Stem Cell Research;Substantia nigra structure;Synapses;Technology;Testing;Therapeutic;Time;Tissues;Tracer;transcriptomics;Transplantation;tumorigenic;Undifferentiated;Variant;Wheat Germ Agglutinins

PROJECT_TITLE: Human iPSC-Based Personalized Cell Therapy of PD

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: PITTSBURGH

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Narrative  Life of all organisms, including humans, depends on the activation of small stable molecules by metalloproteins to provide selective and rapid chemical transformations. The goal of the proposed research is to elucidate how specific metalloenzymes function by monitoring and analyzing the atomic level changes that occur at the metal active site during the reaction and thus provide a molecular basis for finding causes and remedies of diseases. The focus of the research efforts will be on how the interfacing of the active sites in metalloproteins with the protein matrix affects enzymatic function.

PI_NAMEs: HENDRICH, MICHAEL P (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Advanced Spectroscopic and Computational Analysis of Metal Sites in Enzymes, Biomimetic Models, and Catalytic Intermediates.


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_CITY: MADISON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE This research advances our understanding of how the brain generates predictions which shape how we perceive the world, otherwise known as predictive coding. Predictive coding is relevant to public health because it holds great promise in conceptualizing and treating brain disorders, including depression, schizophrenia, delirium and dementia, as well as understanding sleep and anesthesia. Progress in understanding the basic mechanisms of predictive coding, as well as predictive coding deficits, is a necessary step in developing more effective treatment strategies for multiple health conditions.

PI_NAMEs: SAALMANN, YURI B (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Adrenergic Receptor;Agonist;Anesthesia procedures;Anesthetics;antagonist;Area;Auditory;Auditory area;Awareness;Behavior;Brain;Brain Diseases;Code;Complex;Computer Models;Conscious;Cues;Data;Delirium;Dementia;Dexmedetomidine;Disinhibition;Dose;Dreams;effective therapy;Electroencephalography;Environment;experience;Experimental Designs;experimental study;Feedback;frontal lobe;Future;Goals;Health;Human;human data;Impairment;improved;Individual;innovation;innovative technologies;insight;Interneurons;Intervention;Ketamine;Link;Macaca;Machine Learning;Measures;Mediating;Mental Depression;Modality;Modeling;Molecular Target;Monitor;multi-electrode arrays;N-Methyl-D-Aspartate Receptors;neural;neural correlate;neuromechanism;Neurons;neurophysiology;nonhuman primate;Organ;paired stimuli;Pathway interactions;Perception;pharmacologic;postsynaptic;Presynaptic Terminals;prevent;Process;Propofol;Public Health;Pulvinar structure;Reaction Time;receptor;Reporting;Research;response;Role;Schizophrenia;Sedation procedure;sedative;Sensory;sensory cortex;Sensory Process;sensory stimulus;Shapes;Signal Transduction;Sleep;Study models;System;Temporal Lobe;Testing;Thalamic Nuclei;therapeutic development;transmission process;treatment strategy;Unconscious State;Update;visual stimulus

PROJECT_TITLE: Receptors, microcircuits and hierarchical connectivity in predictive coding and sensory awareness

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE The transport of molecular complexes from the nucleus to the cytoplasm is essential for most developmental processes and has been thought to occur only through specific openings in the nuclear envelope/membrane. A new alternate export pathway was recently described wherein large molecular complexes exit the nucleus by ‘budding’ through the nuclear envelope/membrane, a process that we find requires the highly-conserved WASH subfamily of Wiskott-Aldrich Syndrome (a disease with clinical symptoms including immune deficiency and cancer) proteins. These studies are expected to provide new insight into the rules governing this new nuclear export pathway in normal cellular processes, the consequences of inappropriate regulation leading to disease conditions such as laminopathies, neurological disorders, aging, herpesvirus infections, and/or cancer onset/progression, as well as provide a fresh basis for new potential therapeutic developments.

PI_NAMEs: PARKHURST, SUSAN M (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Actins;Aging;Biochemical;Biological;Bypass;Caring;Cell Nucleus;Cell Physiology;Cell Proliferation;Cells;Clinical;clinically relevant;Complex;Cytomegalovirus Infections;Cytoplasm;design;Development;Developmental Process;Disease;Drosophila genus;Elements;Encapsulated;Engineering;Event;experimental study;Family;Foundations;Genes;Genetic;Goals;Growth;Herpesviridae;Herpesviridae Infections;Image;Immune system;immunodeficiency;information gathering;insight;interest;Intervention;Kinesin;Learning;macromolecule;Malignant Neoplasms;Mammalian Cell;Mechanics;Mediating;Membrane;Microscopy;Molecular;Movement;Nervous System Disorder;new therapeutic target;novel;Nuclear;Nuclear Envelope;Nuclear Export;Nuclear Inner Membrane;Nuclear Lamina;Nuclear Outer Membrane;Nuclear Pore;Nuclear Pore Complex;Nucleic Acids;nucleocytoplasmic transport;Oogenesis;optogenetics;Organism;Pathway interactions;Physiological;Predisposition;Process;Proteins;Proteomics;Reagent;Regulation;Ribonucleoproteins;RNA;Role;spatiotemporal;superresolution imaging;Symptoms;synaptogenesis;Syndrome;System;Techniques;therapeutic development;trafficking;Transplant Recipients;Transport Process;tumor;tumor progression;ultra high resolution;Viral;Wiskott-Aldrich Syndrome;Wiskott-Aldrich syndrome protein;Work

PROJECT_TITLE: Cellular mechanisms of nucleocytoplasmic export through Nuclear Envelope Budding

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


NIH_SPENDING_CATS: Cancer;Clinical Research;HIV/AIDS;Hematology;Hodgkin's Disease;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PHR: PROJECT NARRATIVE Subversion of the B cell receptor (BCR) signaling pathway is a cardinal feature of B cell lymphoma. This pro- posal investigates how the Epstein-Barr virus (EBV) LMP2A oncogene interacts with the BCR, maintaining it in its growth promoting IgM isotype, and creating dependence upon antigen-induced signaling for EBV trans- formed cells expressing LMP2A. Completion of this proposal will provide a framework of knowledge defining interactions between LMP2A and the BCR and identify strategies for targeting dependencies of EBV+ lympho- mas on the antigen-induced signaling pathway.

PI_NAMEs: JOHANNSEN, ERIC C (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Antibodies;Antigens;antiretroviral therapy;Automobile Driving;B Cell Proliferation;B-Cell Antigen Receptor;B-Cell Lymphomas;B-Lymphocytes;BLNK gene;cell transformation;Cells;Characteristics;Clinical;clinical predictors;Complex;Cytotoxic Chemotherapy;Data;Dependence;design;Development;Diffuse Large-Cell Lymphoma;Drug resistance;Epstein Barr Virus B cell lymphoma;Epstein-Barr Virus Infections;Epstein-Barr Virus-Related Lymphoma;Failure;Gene Expression Profile;Growth;high risk;HIV;Hodgkin Disease;Human Herpesvirus 4;humanized mouse;Immunocompromised Host;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin Isotypes;Immunoglobulin M;Impairment;improved;In Vitro;in vivo;Individual;infected B cell;inhibitor;Knowledge;lymphoblastoid cell line;Lymphocyte Activation;Lymphoma;Lymphomagenesis;Mediating;Mediator;Morbidity - disease rate;mortality;mutant;Non-Hodgkin's Lymphoma;novel;nuclear factors of activated T-cells;Oncogenes;Oncogenic;Outcome;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Plasma Cells;Play;Predisposition;Process;Proliferating;Proteins;Receptor Signaling;Resistance;response;Role;Signal Induction;Signal Pathway;Signal Transduction;Signaling Molecule;stem;targeted agent;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Tissue-Specific Gene Expression;transforming virus;transmission process;tumorigenesis;Viral;Viral Oncogene

PROJECT_TITLE: Role of Epstein-Barr virus LMP2A protein in maintaining oncogenic IgM signaling in EBV+ B cell lymphomas


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because understanding changes in coagulation factors that might increase the risk of a blood clot among transgender and gender nonconforming adolescents and young adults who are using estrogen for gender-affirming hormone therapy is important for physicians counseling transgender people about the risks of a blood clot, and for patients and their families to be able to make informed decisions about their health care. This research will also provide information about which youth with other risk factors for a blood clot should be evaluated and perhaps start anticoagulation before starting gender- affirming hormone therapy. Overall, the information that is learned from this work is important to the development of tools for both gender care clinicians and hematologists in order to standardize clinical practice, reduce health care inequalities, and improve the overall health of transgender and gender nonconforming adolescents and young adults.

PI_NAMEs: MULLINS, TANYA L. KOWALCZYK (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: activated Protein C;Adherence;Adolescent and Young Adult;Adult;Age;Age Years;Androgens;Anticoagulation;assigned female at birth;assigned male at birth;Attitude;Behavior;Benefits and Risks;Biological;Blood coagulation;Blood Coagulation Factor;Caring;Childhood;cis-female;Clinical;clinical development;clinical practice;Coagulation Process;cognitive interview;cohort;Contraceptive methods;Counseling;Data;Decision Making;design;Educational Intervention;effective intervention;Estradiol;Estrogens;Evaluation;Event;Exhibits;experience;Family;Female;Fibrin fragment D;Foundations;Gender;gender affirming hormone therapy;gender dysphoria;gender nonconforming;Generations;Genetic Polymorphism;Goals;Guidelines;Health;health care disparity;Healthcare;Hematologist;Hemostatic Agents;Hemostatic function;high risk;Hormone replacement therapy;Hormone use;Human Biology;human disease;improved;Individual;Influentials;inhibitor;innovation;Institution;Intention;Intervention;Interview;Knowledge;Learning;Measurable;Mental Depression;Mental Health;method development;novel;Outcome;Patients;Pediatric Hematologist;Persons;physical conditioning;Physicians;pilot test;Platelet Activation;Population;Prophylactic treatment;prospective;Public Health;Recommendation;reducing suicide;Reporting;Research;Research Methodology;Resistance;Risk;Risk Factors;Sampling;Standardization;suicidal risk;Suicide;Suicide attempt;Surveys;System;Telephone;Testosterone;Thrombin;Thrombophilia;Thrombosis;thrombotic;Time;tool development;transgender;transgender women;Treatment Protocols;Variant;Visit;Work;Youth

PROJECT_TITLE: Thrombosis Risk in Transgender Adolescents and Young Adults Starting Gender-Affirming Hormone Therapy

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Diabetes;Genetics;Infectious Diseases;Wound Healing and Care

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Diabetic wound infections are commonly colonized with pathogenic bacteria such as Group B Streptococcus (GBS) and Staphylococcus aureus, which leads to prolonged wound healing and poor patient outcomes. However, the mechanisms of GBS pathogenesis in the diabetic wound are currently unknown. This proposal seeks to investigate the role of GBS CovRS regulation and regulated factors including plasminogen binding protein, PbsP, and nuclease, NucA, in the diabetic wound, and how S. aureus impacts GBS pathogenesis.

PI_NAMEs: DORAN, KELLY S (contact);HORSWILL, ALEXANDER R

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Address;Adherence;Adult;Amputation;Bacteria;Bacterial Adhesins;Binding;Binding Proteins;Chronic;co-infection;Complement;Complex;Coupled;Data;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;diabetic ulcer;Disease;DNA Binding;Environment;Exhibits;female reproductive tract;Foundations;Genes;Genetic Transcription;Genitourinary system;Genome;Goals;Group B Streptococcus colonization;Hyperpigmentation;Immune Evasion;Immune response;Immune system;Immunocompromised Host;in vitro Model;in vivo;in vivo Model;Incidence;Individual;Infection;Invaded;Lower Extremity;mouse model;Mus;mutant;Mutation;Mutation Detection;neonate;neutrophil;Neutrophil Activation;Neutrophil Infiltration;nuclease;Operative Surgical Procedures;opportunistic pathogen;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Patient-Focused Outcomes;Phenotype;Pigments;Plasminogen;Prevalence;Public Health;Regulation;response;Role;Site;Site-Directed Mutagenesis;Skin;Skin colonization;Staphylococcus aureus;streptococcal group B hemolysin;Streptococcal Infections;Streptococcus Group B;Structural Models;Surface;Testing;Tissues;transcriptome sequencing;Type 2 diabetic;Virulence Factors;Virulent;women's reproductive health;Work;wound;wound care;wound environment;wound healing;Wound Infection

PROJECT_TITLE: Determinants of polymicrobial diabetic wound infections


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Hematology;Orphan Drug;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: HOUSTON

ORG_NAME: RICE UNIVERSITY

PHR: Project Narrative Sickle cell disease (SCD) is a genetic disease that affects millions of people worldwide, causing frequent pain episodes, stroke, organ damage and a median life expectancy in the mid-forties. We propose to determine the detrimental and potentially beneficial effects of unintended large gene modifications due to Cas9-cutting, and develop ways to reduce large deletions, with the goal of increasing the efficacy and safety of genome editing based treatment of SCD.

PI_NAMEs: BAO, GANG  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Address;Adoption;Affect;Alleles;Allogenic;American;Autologous;base;base editing;beta Globin;Biological;Blood specimen;Blood Transfusion;Bone Marrow;Cell Separation;Cells;Chronic;Chronic Disease;Clinical;clinical practice;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR therapeutics;CRISPR/Cas technology;curative treatments;Data;design;Development;DNA Repair;Engraftment;Enhancers;Erythroid;Erythroid Cells;Erythropoiesis;Evaluation;Fetal Hemoglobin;Frequencies;Gene Modified;gene-editing approach;Genes;Genetic Diseases;genome editing;Genotype;Goals;graft vs host disease;Guide RNA;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Heterogeneity;Immunodeficient Mouse;improved;insertion/deletion mutation;Life Expectancy;Lymphoid;Methods;Morbidity - disease rate;mortality;Mus;Mutation;Myelogenous;novel strategies;Oligonucleotides;Organ;Outcome;Pain;palliative;Pathway interactions;Patients;peripheral blood;Persons;pharmacologic;Pharmacologic Substance;Phase I Clinical Trials;Phenotype;prevent;Reporting;Research;RNA analysis;Safety;Sickle Cell Anemia;sickling;single molecule real time sequencing;single-cell RNA sequencing;Site;Stroke;Testing;therapeutic genome editing;Time;transcriptomics;Translations;treatment strategy

PROJECT_TITLE: Deciphering unintended large gene modifications in gene editing for sickle cell disease

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Program Director/Principal Investigator: Castillo, Eliseo, F PROJECT NARRATIVE Plastic pollution and the breakdown of plastic materials primarily into micron-sized microplastic particles (MP) have contaminated our food and water sources, raising ecological and public health concerns. MP ingestion by humans is now an inevitable consequence of global plastic pollution and there is a critical gap in knowledge regarding how MP affects the gastrointestinal (GI) tract in healthy and susceptible (i.e. Inflammatory Bowel Disease) populations. The studies proposed in this grant application seek to understand how MP impact the gut microbiota, intestinal epithelium, and the immune system. The data derived from these studies will be crucial in identifying MP influences on GI health and how to combat MP associated pathologies.

PI_NAMEs: CASTILLO, ELISEO F (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Adherent Culture;Affect;Applications Grants;Awareness;Caco-2 Cells;Cell Line;Cell Respiration;Chronic;Colon;combat;Data;Dose;dysbiosis;Environmental Health;Epithelial Cells;Epithelium;Exposure to;Food;Functional disorder;gastrointestinal;Gastrointestinal tract structure;General Population;Glycolysis;Goals;gut dysbiosis;gut inflammation;gut microbiota;Health;Health Hazards;health knowledge;Human;Immune system;in vivo;Individual;Inflammatory;Inflammatory Bowel Diseases;Ingestion;insight;intestinal epithelium;intestinal homeostasis;Intestinal permeability;Intestines;Knowledge;Maintenance;Metabolic;Metabolism;metabolome;microbial community;mitochondrial metabolism;Modeling;monolayer;Mus;novel;Organ;Organoids;Oxygen;Oxygen Consumption;particle;particle exposure;Pathology;Pathway interactions;Patients;Persons;Planet Earth;Plastics;Pollution;Population;Predisposition;preservation;prevent;Principal Investigator;programs;Proteins;Public Health;Research;Risk;Source;System;systemic inflammatory response;Testing;Tight Junctions;UV Radiation Exposure;Water;Zebrafish

PROJECT_TITLE: Defining the Harmful Effects of Microplastics on Gastrointestinal Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-H(05)]


NIH_SPENDING_CATS: Hematology;Immunotherapy;Rare Diseases

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Cereblon plays a role in selecting protein substrates for degradation as part of the cell’s protein degradation machinery. The substrates that cereblon selects for degradation are tailored by small molecules to promote human health in the clinic, yet how cereblon selects its native substrates and what these substrates are is unknown. Here we will use chemical approaches developed in our lab to illuminate cereblon’s substrate selection mechanism via a novel post-translational modification for identification of these substrates and their biological pathways.

PI_NAMEs: WOO, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Address;Aging;Amines;Amino Acid Sequence;analog;anti-cancer;Asparagine;Binding;Biological;Biological Assay;Biological Process;biological systems;C-terminal;Cells;Chemicals;chemoproteomics;chromosome 5q loss;Clinic;Complex;Coupled;Cyclization;Data;Development;Dipeptides;Dysmyelopoietic Syndromes;Elements;Engineering;Enzymes;Evaluation;Event;Generations;Glues;Glutamine;glutarimide;guided inquiry;Health;Hematopoietic Neoplasms;Human;Imides;immune modulating agents;In Vitro;inhibitor;insight;Investigation;Kinetics;Label;lenalidomide;Libraries;Ligands;Maps;Measurement;Modeling;Modification;Molecular;multicatalytic endopeptidase complex;Multiple Myeloma;Neurologic;novel;novel strategies;nucleophilic addition;Pathway interactions;Patients;Peptides;Periodicity;Physiological;Play;pomalidomide;Post-Translational Protein Processing;protein degradation;Proteins;Proteome;Proteomics;Reader;recruit;Regulation;response;Role;Signal Transduction;Site;small molecule;Specificity;Substrate Specificity;System;Teratogenic effects;Thalidomide;Therapeutic;therapeutic development;Therapeutic Effect;tissue culture;Tissue Sample;Ubiquitin;ubiquitin-protein ligase;Work;Writing

PROJECT_TITLE: Uncovering the substrate recognition mechanisms of the E3 ligase adaptor cereblon

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Narrative Cognitive processes emerge as neural circuits form through expression of genes over the course of development, though it remains unknown how genes function at the cellular level to promote activity- dependent in vivo development of cortical circuit motifs known to promote cognitive function and behavioral adaptations. The impact of this proposed research is that it has the potential to reveal how gene expression shapes the activity-dependent assembly of neural circuits that promote cognitive functions required for behavioral adaptations.

PI_NAMEs: RUMBAUGH, GAVIN R (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Area;autism symptoms;Basic Science;Behavior;Behavioral;behavioral impairment;Biological Process;Brain;Brain Diseases;Candidate Disease Gene;Cells;Cerebral cortex;Childhood;cognitive ability;cognitive function;cognitive process;course development;Data;Decision Making;Development;Disease;Etiology;excitatory neuron;Gene Expression;Gene Expression Regulation;gene function;Genes;Genetic;Glutamates;Goals;Human;Image;Impaired cognition;Impairment;in vivo;insight;Ion Channel;Kv4 channel;Learning;Link;loss of function;maladaptive behavior;Mediating;Membrane;Molecular;Morphogenesis;Mus;neural;neural circuit;Neurobiology;Neurodevelopmental Disorder;Neurons;neurophysiology;novel;Organ;Pathway interactions;Perception;Perceptual learning;Perinatal;Peripheral;Potassium Channel;Process;Protein Isoforms;Proteins;ras GTPase-Activating Proteins;Regulation;Research;Research Design;response;risk variant;RNA Splicing;Role;Sensory;sensory cortex;Shapes;Signal Transduction;Somatosensory Cortex;Structure;Surface;Synapses;SYNGAP1;Testing;Thinking;tool;Touch sensation;two-photon;Vibrissae;Work

PROJECT_TITLE: Neurodevelopmental Disorder Risk Gene Regulation of Intrinsic Membrane Excitability: A Rheostat that Tunes Dendritic Morphogenesis to Regulate Circuit Assembly During Development


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Cannabinoid Research;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Health Services;Maternal Health;Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Serious Mental Illness;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE This study examines the effects of prenatal cannabis exposure on fetal brain development. We will enroll pregnant women (n=450) during the first trimester gestation, obtain fetal MRI scans during the 3rd trimester, and then follow the infants on cognitive and behavioral measures over their first two years of life. Given the lack of clarity on the safety of cannabis use during pregnancy, findings will have important public health implications by informing prevention strategies particularly in this era of increasing cannabis use in the prenatal period.

PI_NAMEs: LUGO-CANDELAS, CLAUDIA I;OUELLET, ANNIE ;POSNER, JONATHAN E (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Alcohols;Anxiety;anxiety symptoms;Attention deficit hyperactivity disorder;Autopsy;Behavior assessment;behavior measurement;Behavioral;behavioral outcome;Benign;Binding;Blood - brain barrier anatomy;Brain;brain behavior;brain research;Canada;Cannabis;Child;Cigarette;CNR1 gene;Cocaine;Cognitive;Collaborations;Corpus striatum structure;critical period;Data;data collection site;delivery complications;demographics;design;Development;Dopamine;Drug usage;Early identification;Enrollment;Environment;Environmental Risk Factor;epidemiology study;Executive Dysfunction;executive function;Exposure to;Family;Female;fetal;fetal blood;fetal drug exposure;fetal marijuana exposure;First Pregnancy Trimester;Functional Magnetic Resonance Imaging;Future;Genetic;health care availability;Health Policy;Healthcare Systems;High Prevalence;high risk population;Home environment;Human;human fetal brain;hypothalamic-pituitary-adrenal axis;impression;in utero;indexing;Infant;Infant Behavior;Intervention;Laboratories;Legal;Life;Link;Magnetic Resonance Imaging;male;marijuana legalization;marijuana use;marijuana use in pregnancy;maternal anxiety;maternal depression;Measures;Mediating;Medical center;mesolimbic system;migration;Minnesota;mood symptom;Moods;Mothers;MRI Scans;Nausea;neural;neurodevelopment;neurodevelopmental effect;neuroimaging;Neurons;North America;novel;offspring;Opioid;Outcome;Parents;Patient Self-Report;Perinatal;Pharmaceutical Preparations;Phenotype;Placenta;postnatal;Postpartum Period;pre-clinical;Predisposition;Prefrontal Cortex;Pregnancy;Pregnant Women;premature;prenatal;Prenatal care;prenatal exposure;Prevention;Prevention strategy;Psychoses;Public Health;Quebec;receptor expression;Recording of previous events;Recreation;Reporting;Research;Risk;Rodent;Safety;sex;Specificity;Stress;Structure;Substance of Abuse;substance use;synaptogenesis;Teenagers;tertiary care;Tetrahydrocannabinol;Third Pregnancy Trimester;tool;Toxicology;Universities;Withdrawal Symptom;Woman;women versus men;young adult

PROJECT_TITLE: Prenatal cannabis: A fetal neuroimaging study of neurodevelopment

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Clinical Research;Kidney Disease;Neurosciences;Pediatric;Urologic Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative New findings from our group have identified a panel of urine biomarkers enriched in urine from two models of neurogenic bladder (human and rodent), not detected in kidney urine from human patients with ureteropelvic junction obstruction, and present in bladder tissue from rats with neurogenic bladder suggesting they reflect pathological bladder wall remodeling as opposed to renal damage. The proposed studies will test the hypothesis that our Non-Invasive Markers of Bladder Deterioration (NIMBLE) represent prognostic markers of deterioration in bladder function in neurogenic bladder patients, and will provide new insights into alterations in the urinary proteome in the context of neurogenic bladder, its association with functional deterioration and response to intervention.

PI_NAMEs: ADAM, ROSALYN M;LEE, RICHARD SANG-YONG (contact)

PROJECT_TERMS: Anti-Cholinergics;Biological Markers;biomarker panel;Bladder;Bladder Tissue;Catheterization;Child;Chronic Kidney Failure;Clinical;Clinical Management;cohort;Complement;Detection;Deterioration;Development;Dysmyelopoietic Syndromes;Evaluation;Human;improved;insight;Interobserver Variability;Intervention;intravesical;Kidney;Longitudinal cohort;Lower urinary tract;Mass Spectrum Analysis;Modeling;Monitor;Neurogenic Bladder;Obstruction;Operative Surgical Procedures;Pathologic;patient population;Patients;Pharmaceutical Preparations;pharmacologic;Population;postnatal;prenatal;preservation;pressure;Prognostic Marker;prospective;Prospective cohort;Proteins;Proteome;Proteomics;Protocols documentation;Rattus;renal damage;Renal function;repaired;response;Risk;Rodent;Sampling;Signal Transduction;Spinal Dysraphism;tertiary care;Testing;Time;Tissues;treatment response;Ureteropelvic junction obstruction;urinary;Urinary tract;Urinary tract infection;Urine;Urodynamics;urologic

PROJECT_TITLE: NIMBLE: Non-Invasive Markers of Bladder Deterioration

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Disability Research;Mental Health;Neurosciences;Opioids;Pain Research;Prevention;Rehabilitation;Social Determinants of Health;Telehealth

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE The proposed study will address the significant and complex public health problems of postsurgical chronic pain and the opioid epidemic utilizing a biopsychosocial paradigm that is recommended but not yet well-integrated in orthopaedic surgical practice. Effective nonpharmacological treatment options that address pain and common psychosocial risk factors after spine surgery are needed but have not been tested and widely disseminated. The proposed study will adapt and refine a telehealth mindfulness-based intervention that addresses the unique pain concerns facing the large number of patients who undergo lumbar spine surgery and will provide important data on feasibility to inform the development of future trials investigating efficacy, mechanisms, and predictors of treatment response.

PI_NAMEs: BRINTZ, CARRIE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: CHIDEYA-CHIHOTA, SEKAI RUTENDO

PROJECT_TERMS: 3-Dimensional;Academic Medical Centers;acceptability and feasibility;Address;Adult;Affect;Age;Anxiety;Area;arm;Award;Behavior Therapy;Belief;biopsychosocial;career;career development;central sensitization;Chronic disability;chronic pain;Clinical Investigator;Clinical Research;Clinical Trials;Clinical Trials Design;clinically relevant;Complex;Data;Data Analyses;Data Collection;design;Development;disability;Education;emotional distress;Enrollment;experience;Feedback;functional improvement;Future;Goals;Grant;group intervention;Growth;high risk;Home;Hour;improved;Individual;Information Dissemination;Infrastructure;Intervention;intervention participants;intervention refinement;Intervention Trial;Interview;Knowledge;learning strategy;Measures;meetings;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Mind-Body Intervention;mindfulness;mindfulness intervention;multidisciplinary;National Center for Complementary and Integrative Health;negative affect;Neuronal Plasticity;Nonpharmacologic Therapy;online delivery;Operative Surgical Procedures;Opioid;opioid epidemic;opioid use;Orthopedic Surgery;Orthopedics;Outcome;Pain;Pain intensity;Pain interference;Pain management;Pain Measurement;pain outcome;pain processing;pain sensitivity;Participant;patient oriented;Patient Outcomes Assessments;patient population;patient subsets;Patients;Persistent pain;Persons;Physical Function;Population;post intervention;Postoperative Pain;Postoperative Period;Practice Management;Prediction of Response to Therapy;prescription opioid;Procedures;programs;Prospective Studies;Protocols documentation;psychological distress;Psychophysics;psychosocial;Psychosocial Factor;Public Health;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Recovery;Reporting;Research;research data dissemination;Research Project Grants;Research Training;Resources;Risk Factors;satisfaction;Science;Self Efficacy;skills;Spine pain;Spine surgery;Structure;Surveys;System;telehealth;Testing;Time;Training;Treatment outcome;United States;Vertebral column;videoconference;Work;Writing

PROJECT_TITLE: Postoperative Telehealth Mindfulness Intervention to Improve Pain-related Outcomes and Reduce Opioid Use after Lumbar Spine Surgery


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative A growing literature finds associations between food security and mental health, positing a bi-directional relationship, wherein food insecurity increases stress and anxiety leading to poorer mental health, and serious mental illness impairs consistent access to food. In this proposal, we aim to elucidate the causal relationship between increased food security and mental health. To do this, we leverage a natural experiment during the COVID-19 pandemic where the federal government dramatically increased household SNAP beneficiary allotments for eligible families and assess its impact on symptoms, treatment, and outcomes.

PI_NAMEs: NDUMELE, CHIMA  (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Adherence;adverse outcome;American;Anxiety;Area;behavioral health;beneficiary;Budgets;care systems;Clinical;comorbidity;Connecticut;Consumption;cost;COVID-19;COVID-19 pandemic;Data;Data Set;design;diabetes risk;Diagnosis;Eligibility Determination;Emergency response;exhaust;exhaustion;Family;Family Leave;Federal Government;Food;Food Access;food insecurity;Food Policy;food security;Frequencies;Health;Health Care Costs;health care service utilization;Health Food;Health Policy;Health Services;Heart Diseases;Hospitalization;Household;Housing;Impairment;improved;Income;Individual;Interdisciplinary Health Team;Intervention;Investments;Link;Literature;Low income;Low Income Population;lower income families;Malnutrition;Mediating;Medicaid;Mental disorders;Mental Health;Natural experiment;novel;nutrition;Outcome;pandemic disease;Pathway interactions;Pattern;Persons;Physicians;Physiologic pulse;Policies;policy implication;Population;Positioning Attribute;Poverty;pre-pandemic;programs;Public Health;Recommendation;Reporting;Research Personnel;Residual state;Resources;response;severe mental illness;social;social determinants;Stress;Surveys;Symptoms;Testing;Uncertainty

PROJECT_TITLE: Leveraging SNAP to Improve Mental Health Outcomes: Evidence from the COVID-19 Emergency Response


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: This proposal aims to uncover regulatory paradigms underlying how reprogramming factors trigger widespread gene expression changes, by deciphering the regulatory logic of the early embryo that leads to genome activation and the establishment of pluripotent stem cells. Transcriptional reprogramming underlies disorders of cell identity such as cancer, and understanding how gene expression can be reprogrammed is fundamental to developing strategies to treat such disorders. Additionally, the potential to precisely manipulate cellular identity through transcriptional reprogramming has enormous implications for disease modeling and therapies, thus motivating the need to discover novel vertebrate mechanisms that contribute to this process.

PI_NAMEs: LEE, MILER T. S. (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Address;Affect;Binding;Biochemical;cell type;Cells;Development;Disease;disease model;egg;Embryo;Gene Activation;Gene Expression;Genes;genetic approach;Genetic Transcription;Genome;genome-wide;genomic data;Goals;Hour;Human;innovation;Logic;loss of function;Malignant Neoplasms;Maps;Maternal Messenger RNA;Measures;Modeling;novel;Organism;Pattern;pluripotency;pluripotency factor;Pluripotent Stem Cells;posttranscriptional;Process;programs;Property;Source;Specificity;System;Techniques;transcriptional reprogramming;transcriptome;vertebrate embryos;Vertebrates;Zebrafish

PROJECT_TITLE: Transcriptome reprogramming in the early embryo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative This longstanding MPI grant focuses on understanding the mechanistic underpinnings of a major pathway of R-loop resolution that is indispensable for the maintenance of genome stability. Multidisciplinary studies directed at delineating physical interactions and functional synergy between Senataxin and the tumor suppressor complex BRCA1-BARD1 will shed light on the nature of disease causative mutations in adult and pediatric cancers and in neurological disorders caused by the inactivation of Senataxin. The results from our joint venture should constitute the intellectual basis for devising strategies to advance cancer prevention, diagnosis, and treatment.

PI_NAMEs: KUPFER, GARY M.;SUNG, PATRICK  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Adult;Advanced Malignant Neoplasm;BARD1 gene;Biochemical;Biological;Biological Assay;Biological Process;Biology;Bone marrow failure;BRCA1 gene;cancer prevention;causal variant;Cell Extracts;Cell Physiology;Cell Survival;Cells;Cellular biology;Chromosomal translocation;Co-Immunoprecipitations;Collaborations;Complex;Coupled;Data;Diagnosis;Disease;Dissection;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Repair;DNA Repair Pathway;DNA replication fork;DNA Structure;Event;Family;Fanconi's Anemia;Genetic Models;Genetic Recombination;Genetic Transcription;Genome;genome integrity;Genome Stability;Grant;Head;helicase;Hematopoiesis;Hybrids;In Vitro;insight;Joint Ventures;Link;Maintenance;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Mediating;Messenger RNA;Methods;Modeling;multidisciplinary;Mutagenesis;mutant;Mutation;Nature;Neoplastic Cell Transformation;Nervous System Disorder;novel;Nucleic Acid Amplification Tests;Nucleic Acid Binding;nucleic acid structure;Nucleic Acids;Obstruction;Paper;Pathologic;Pathway interactions;Pediatric Oncologist;Physicians;Physiological;preservation;Process;Productivity;Property;Proteins;Publishing;reconstitution;Repair Enzymology;replication stress;Research Personnel;Resolution;response;RNA;RNA Splicing;Role;Scientist;SF1;Single-Stranded DNA;Site;Stress;Structure;Structure-Activity Relationship;Substrate Specificity;synergism;System;Testing;Time;Transcript;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis

PROJECT_TITLE: Mechanistic Dissection of the BRCA1-SETX-dependent Pathway of R-loop Avoidance and Genome Maintenance

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]