NIH_SPENDING_CATS: Aging;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Macular Degeneration;Neurodegenerative;Neurosciences;Rural Health;Social Determinants of Health

PI_NAMEs: KLINGEBORN, MIKAEL  (contact)

PROJECT_TERMS: Address;age related;Age related macular degeneration;aged;Aging;aging related;American;Animal Model;base editing;Biological;Biology;Blindness;Blood-Retinal Barrier;Cell Culture Techniques;Cell Line;Cells;Cellular biology;Centers of Research Excellence;Choroid;Circulation;Compensation;Complex;Coupled;Deposition;Desmosomes;Diagnosis;diagnostic screening;Disease;Drusen;Endosomes;Environment;Environmental Risk Factor;environmental stressor;Enzymes;Epithelial Cells;exosome;Experimental Models;Extracellular Matrix;extracellular vesicles;Eye;Foundations;Functional disorder;functional restoration;gene therapy;Generations;Genes;Genetic Risk;Genotype;Health;health care settings;Hemidesmosomes;Image;In Situ;In Vitro;in vivo;induced pluripotent stem cell;innovation;Intervention;knock-down;late-onset retinal degeneration;Lipids;Lipoproteins;Mediating;Mentorship;Modeling;monolayer;Montana;mouse model;mutant;Mutation;nanosized;National Eye Institute;Natural regeneration;Nerve Degeneration;neurobehavioral;Neurodegenerative Disorders;novel;novel strategies;novel therapeutic intervention;Ophthalmologist;overexpression;Oxidative Stress;particle;Pathologic;Pathway interactions;patient derived induced pluripotent stem cells;Patients;pharmacologic;Phenotype;Photoreceptors;Play;prevent;Process;programs;protein misfolding;Protein Secretion;Proteins;Quality of life;Research;Research Institute;response;Retina;Retinal Degeneration;Retinal Diseases;Retinal Pigments;Role;rural area;Rural Community;Rural Health;Side;Site;small hairpin RNA;Source;Stress;Structure of retinal pigment epithelium;Testing;Therapeutic;Therapeutic Intervention;Tight Junctions;Time;translational goal;Transportation;urban area;Vision;Work

PROJECT_TITLE: Modulation of Exosome Release for Functional Restoration in Age-related Retinal Disorders


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging;Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Rare Diseases;Rural Health;Social Determinants of Health

ORG_CITY: GREAT FALLS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MC LAUGHLIN RESEARCH INSTITUTE

ORG_STATE: MT

PI_NAMEs: LEAVENS, MOSES  (contact)

PROJECT_TERMS: Address;agricultural community;Alleles;alpha synuclein;Amyotrophic Lateral Sclerosis;antioxidant enzyme;assay development;Autopsy;Behavior;behavior test;Biological Assay;Brain Diseases;Brain region;brain tissue;career;Cell model;Cells;Characteristics;Chemicals;conformer;Copy Number Polymorphism;Cytoplasm;Data;design;detection assay;Development;Diagnosis;Disease;disease phenotype;Disease Progression;dopaminergic differentiation;dopaminergic neuron;Etiology;Exhibits;experience;Experimental Designs;experimental study;familial amyotrophic lateral sclerosis;Genes;Genetic;genetic variant;Genotype;Goals;Health Professional;Human;human model;human tissue;Idiopathic Parkinson Disease;In Vitro;in vivo;Incidence;innovation;Investigation;Knowledge;Lewy Bodies;Link;Mentors;Mentorship;metalloenzyme;misfolded protein;Molecular;molecular pathology;Montana;mouse model;Mus;mutant;Mutation;neural;neurobehavioral;Neurodegenerative Disorders;neurotoxicity;novel;novel marker;novel strategies;Outcome;Outcome Study;Parkinson Disease;Pathology;Phenotype;Pluripotent Stem Cells;Population;pre-formed fibril;Prions;Process;Property;protein aggregation;Protein Biochemistry;protein folding;protein function;protein structure;Proteins;Provider;Publications;Reactive Oxygen Species;recruit;Reporting;Research;Research Institute;Resources;Role;Rural;Rural Community;Rural Health;scaffold;Sensitivity and Specificity;Severities;Specialist;Structure;Substantia nigra structure;success;Superoxide Dismutase;superoxide dismutase 1;Superoxides;synuclein;System;Technology;Testing;Time;Tissue Model;Tissues;tool;Toxic effect;Travel;treatment strategy;United States;Universities;urban area;Vocational Guidance;Wild Type Mouse;Work

PROJECT_TITLE: Investigation of Superoxide Dismutase I in Parkinson's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-T (C1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Rural Health;Social Determinants of Health;Transmissible Spongiform Encephalopathy (TSE)

PI_NAMEs: GRINDELAND, ANDREA LEE (contact)

PROJECT_TERMS: Address;Affect;American;Animals;Behavior assessment;Behavioral;Biological Assay;Biological Markers;Brain;Brain region;brain tissue;career development;cell type;cervid;Characteristics;Chronic Wasting Disease;Clinical;clinical biomarkers;Clinical Medicine;Codon Nucleotides;Comparative Study;Creatine Kinase;Deer;Detection;Development;Diagnosis;diagnostic tool;Disease;Disease Marker;Disease Outcome;disease phenotype;Disease Progression;Disease Resistance;Doctor of Philosophy;Early Diagnosis;Eating;Equine mule;Faculty;Food;Future;Gait abnormality;Gene Targeting;Genes;Genetic;Genetic Polymorphism;genetic variant;Genotype;Geographic Locations;Goals;Guidelines;Heterozygote;Human;Immunohistochemistry;Incubated;innovation;insight;Investigation;Knock-in Mouse;Knowledge;Laboratories;longitudinal analysis;lymph nodes;Mentors;Mentorship;Methods;Montana;mouse model;Mus;Muscle;Nerve Tissue;neurobehavioral test;Neurodegenerative Disorders;neurofilament protein L;neuropathology;novel;Oral;Organ;overexpression;Peripheral;Phenotype;Phenylalanine;Plasma;Population;Predisposition;Prion Diseases;Prions;Protein Analysis;protein structure;Proteins;PrP;PrP gene;Race;Reindeer;Research;Route;Rural;Rural Health;Safety;Scientist;Serine;Source;Spleen;success;therapeutic evaluation;Time;Tissues;tool;Transgenic Mice;Transgenic Organisms;Universities;Variant;Veterinary Medicine;Western Blotting;Zoonoses

PROJECT_TITLE: Comprehensive Phenotypic Profiling of Chronic Wasting Disease to Assess Transmissibility and Species Barriers


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences;Rural Health;Social Determinants of Health

PI_NAMEs: GUNN, TERESA M (contact)

PROJECT_TERMS: Acclimatization;aerosolized;Animals;Area;Basic Science;Behavior;Behavior assessment;behavior test;Biological Process;Bioluminescence;Biomedical Research;cell motility;cell type;Centers of Research Excellence;Clinical;clinical application;Computer software;Data;Dedications;Development;Disease Progression;Early Diagnosis;Electroretinography;Ensure;Equipment;Equity;Exposure to;Fluorescence;fluorescence imaging;Future;Gait;gait examination;Generations;Genes;Goals;health care availability;Health Personnel;Hydrogen Peroxide;Image;Imaging Device;imaging study;imaging system;Imaging technology;improved;In Situ;in vivo bioluminescence imaging;in vivo imaging;in vivo imaging system;Interdisciplinary Study;Investments;Lighting;Longitudinal Studies;Magnetic Resonance Imaging;medical schools;Monitor;Montana;motor impairment;mouse model;multidisciplinary;Mus;neurobehavior;neurobehavioral;neurobehavioral test;novel diagnostics;novel therapeutics;optical imaging;Phenotype;pre-clinical;Pre-Clinical Model;Procedures;protein aggregation;Reproducibility;Reproducibility of Results;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Research Support;Resources;response;Rural Health;serial imaging;Services;System;Systems Analysis;Technology;Testing;training opportunity;Translational Research;Translations;treadmill;treatment response;Vision;Visualization

PROJECT_TITLE: Alterations & Renovations for Enhanced Phenotyping


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Pediatric

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The inappropriate differentiation of smooth muscle cells (SMCs) results in various diseases, including aortic aneurysms. PRDM6 is an epigenetic regulator of SMC differentiation. Its loss causes diverse cardiovascular diseases. We plan to examine how PRDM6 expression is regulated and how it regulates its target genes.

PI_NAMEs: MANI, ARYA  (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Acetylation;Adopted;Aneurysm;Angiotensin II;Aorta;Aortic Aneurysm;Aortic coarctation;ascending aorta;Atherosclerosis;Atrial Flutter;beta catenin;Binding Sites;Biological Assay;blood pressure regulation;Blood Vessels;Body mass index;Cardiac;Cardiovascular Diseases;Cardiovascular Pathology;Cell Differentiation process;cell motility;Cells;ChIP-seq;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Coronary Arteriosclerosis;Cues;Data;Development;Diameter;Disease;Disease Pathway;Enhancers;Epigenetic Process;Gene Expression Regulation;gene network;Genes;Genetic;Genetic Transcription;genetic variant;genome wide association study;genome-wide;Goals;Growth;Health;Hemorrhage;Heterozygote;Human;Hyperplasia;Hypertension;Impairment;inhibitor;insight;Intervention;Intracranial Aneurysm;Investigation;Knockout Mice;Link;loss of function mutation;Lung;malformation;Mus;Myocardium;Neural Crest;Neural Crest Cell;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Operative Surgical Procedures;Organ;Palliative Surgery;Patent Ductus Arteriosus;Pathway interactions;pharmacologic;Phenotype;Physiology;postnatal;prenatal;Pulmonary Hypertension;Recurrent disease;Regulation;repaired;Reporter;response;restraint;Role;Sampling;Smooth Muscle;Smooth Muscle Myocytes;Systemic hypertension;therapeutic target;Thoracic aorta;Tibial Arteries;Tissues;trait;transcription factor;Transcriptional Regulation;transcriptomics;Transplantation;Variant;Vascular Diseases;Vascular Smooth Muscle;Wild Type Mouse;WNT Signaling Pathway

PROJECT_TITLE: The transcriptional regulation of smooth muscle genes by PRDM6  in vascular health and diseases

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: SCHOOLS OF EDUCATION

ORG_CITY: STILLWATER

ORG_DEPT: PSYCHOLOGY

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: NARRATIVE Microbiome science permeates much of the current thinking in biomedicine, which is demonstrated by the approximately 100 microbiome scientists at Oklahoma State University (OSU) contributing to research efforts to promote microbiome health and target treatments to reverse microbiome dysbiosis. To further advance microbiome research, we must develop a critical mass of new investigators who can compete successfully for independent funding. The goal of the Oklahoma Center for Microbiome Research is to recruit, mentor, and support Research Project Leaders and generally enhance infrastructure by establishing a research core to provide to customized anaerobic microbiology “culturomics” services.

PI_NAMEs: CONWAY, TYRRELL  (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Acceleration;Address;Adolescent;Aerodigestive Tract;Award;cancer cell;career;career development;Centers of Research Excellence;Cherokee Nation;cohort;Collaborations;college;commensal microbes;Communities;design;Dietary Carotenoid;Disease;dysbiosis;Enhancement Technology;Environment;experience;Faculty;Fostering;Foundations;Funding;Goals;Grant;gut inflammation;gut microbiota;Health;Health Sciences;Human;Human Microbiome;Human Resources;Infrastructure;innovation;Institution;Interdisciplinary Study;Investments;Knowledge;malignant mouth neoplasm;member;Mentors;Microbe;Microbiology;microbiome;microbiome composition;microbiome research;microbiota;Microvirus;mid-career faculty;Mission;Modeling;Oklahoma;Opiate Addiction;opioid withdrawal;oral microbiome;Osteopathic Medicine;Oxycodone;pathogen;Phase;Pilot Projects;Postdoctoral Fellow;professor;Protocols documentation;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Role;Scientist;Services;sound;Specificity;Standardization;Strategic Planning;student mentoring;success;System;Thinking;tool;United States National Institutes of Health;Universities;University adminstration;virome

PROJECT_TITLE: Oklahoma Center for Microbiome Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-4 (C1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Microbiome

PROJECT_TERMS: Address;Advisory Committees;Award;Budgets;career development;Centers of Research Excellence;Communication;Communities;Data;Development;Development Plans;Disease;Educational workshop;Event;experience;Faculty;Funding;Goals;Grant;Health;Human;Institution;interest;Leadership;meetings;Mentors;Microbiology;microbiome composition;microbiome research;Monitor;Office of Administrative Management;Oklahoma;Phase;Pilot Projects;Positioning Attribute;Professional Competence;Program Development;programs;Records;recruit;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Resources;Scientist;Services;success;symposium;United States National Institutes of Health;Vocational Guidance;Writing

PROJECT_TITLE: Oklahoma Center for Microbiology Research


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Microbiome

PI_NAMEs: ELSHAHED, MOSTAFA S (contact)

PROJECT_TERMS: Acceleration;Address;Adolescent;Aerodigestive Tract;Anaerobic Bacteria;Animal Diseases;Automated Annotation;Behavioral;Bioinformatics;Biological Models;career;Cell Separation;Cells;Centers of Research Excellence;Communities;Complement;Consultations;Core Facility;Cost-Benefit Analysis;Databases;design;Dideoxy Chain Termination DNA Sequencing;Dietary Carotenoid;disease diagnostic;dysbiosis;Ecosystem;Exhibits;experience;Experimental Designs;experimental study;flexibility;Funding;Gases;Gastrointestinal tract structure;Genetic;Genome;genome sequencing;Genomics;Goals;Growth;gut microbiome;gut-brain axis;Habitats;Human;Incubators;instrumentation;Interdisciplinary Study;interest;Laboratories;Liquid substance;MALDI-TOF Mass Spectrometry;malignant mouth neoplasm;Mediating;member;Membrane Proteins;Metabolism;Metagenomics;metatranscriptomics;Methods;Microbe;microbial;microbial community;Microbiology;microbiome;microbiome composition;microbiome research;microorganism;Microvirus;Names;nanobodies;Nitrogen;novel strategies;Oklahoma;opioid abuse;opioid withdrawal;Organism;organizational structure;Oxygen;pathogen;Pathogenicity;Patients;Periodicals;Phenotype;Phylogenetic Analysis;Physiological;Planet Earth;Preparation;Procedures;professor;programs;repository;Research;Research Personnel;Research Project Grants;Resources;Role;rRNA Genes;Sampling;Scientist;secondary metabolite;Services;skills;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;sustainable resource;systemic inflammatory response;Techniques;tool;Training;trait;tumor progression;Universities;virome;Work

PROJECT_TITLE: Anaerobic Microbiology Research Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Microbiome;Rare Diseases

PI_NAMEs: HUANG, I-HSIU  (contact)

PROJECT_TERMS: 4-Nitroquinoline-1-oxide;AKT Signaling Pathway;Alcohol consumption;Biological Assay;carcinogenesis;carcinogenicity;Caspase;Cell Line;cell motility;Cell Proliferation;Cells;Cessation of life;chemical carcinogen;Chronic Disease;Collaborations;Communities;Control Groups;Cystine;Data;Dental Hygiene;Development;Disease;Fusobacterium nucleatum;Gene Expression;Genes;Genetic Determinism;gingipain;Goals;Grant;high throughput screening;Human;Human Microbiome;Human papilloma virus infection;In Vitro;in vitro Assay;in vivo;Incidence;Incubated;Individual;interest;Invaded;Libraries;Link;malignant mouth neoplasm;Malignant Neoplasms;member;Methods;microbiome composition;microbiome research;migration;mouse model;mouth squamous cell carcinoma;Mus;Mutagenesis;mutant;novel;Oklahoma;Oncoproteins;oral bacteria;Oral cavity;oral microbial community;oral microbiome;oral pathogen;oral tumorigenesis;PAR-2 Receptor;pathogen;Patients;Peptide Hydrolases;Periodontal Diseases;Periodontitis;periodontopathogen;Phenotype;PI3K/AKT;Play;Porphyromonas gingivalis;Prevotella intermedia;Proliferating;rapid technique;receptor;Recombinants;Research Personnel;Risk Factors;Role;Saliva;saliva sample;Signal Pathway;Structure;Survival Rate;System;Testing;Therapeutic;Time;Tissues;Tobacco use;tool;transcriptome sequencing;transcriptomics;tumor progression;Tumor Promotion;tumorigenesis

PROJECT_TITLE: Oral Pathogen-triggered Progression of Oral Squamous Cell Carcinoma


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Microbiome

PI_NAMEs: KIRCHBERGER, PAUL  (contact)

PROJECT_TERMS: Address;Amendment;Animal Model;Animals;Award;Bacteria;Bacterial Infections;Bacteriophages;Bacteroides;Biological Models;Biology;Capsid;career;career networking;Centers of Research Excellence;Cloning;Collaborations;Collection;Communities;Complementarity Determining Regions;Cytolysis;Data;Dedications;DNA;Drosophila genus;Engineering;Escherichia coli;experience;experimental study;Exposure to;Family;Fluorescence;Funding;Future;Genes;Genetic;Genetic Structures;Genome;Genomics;Goals;Grant;Growth;gut microbes;gut microbiome;gut microbiota;Health;Human;Human Biology;in silico;In Vitro;Infrastructure;insight;Institution;Investigation;Knowledge;Laboratories;Libraries;Mediating;member;Mentorship;Metagenomics;Methods;Microbe;microbial;microbial community;Microbial Physiology;Microbiology;microbiome;microbiome composition;microbiome research;Microvirus;Modeling;novel;Oklahoma;Outcome;Paper;pathogen exposure;Pattern;Phage Receptors;Plasmids;Play;Population;practical application;Prevotella;Production;programs;Publishing;rational design;receptor;Research;Research Personnel;Research Project Grants;reverse genetics;Role;Single Stranded DNA Virus;skills;Specificity;Structure;success;System;Testing;tool;transforming virus;Vertebral column;Viral;Viral Physiology;virology;virome;virtual;Virus;whole genome

PROJECT_TITLE: Engineering host-determinants of novel gut Microviruses


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Complementary and Integrative Health;Diabetes;Digestive Diseases;Microbiome;Natural Products;Nutrition;Obesity;Prevention

PI_NAMEs: LIN, DINGBO  (contact)

PROJECT_TERMS: American;Animal Model;Anti-Inflammatory Agents;Architecture;astaxanthine;Beta Carotene;Biochemical;Blood Glucose;career;Carotenoids;Cell Count;Cells;Chemistry;Chronic Disease;Colon;combat;Communication;cytokine;Data;db/db mouse;Diabetes Mellitus;diabetic;Diet;diet-induced obesity;dietary;Dietary Carotenoid;Dietary Intervention;Dietary Practices;Disease;Disease Progression;dysbiosis;empowerment;Enzymes;Eye;fecal microbiota;fecal transplantation;Fluorescence-Activated Cell Sorting;Food;Funding;Germ-Free;Goals;Goblet Cells;gut health;gut inflammation;gut microbiome;gut microbiota;Health;high risk population;Homeostasis;Human;Human body;Hyperglycemia;IL17 gene;Immune;Immune response;Immune system;Immunity;Immunology;Inflammatory;Intake;Intestinal Mucosa;Intestines;Knockout Mice;Knowledge;Lamina Propria;macula;Metabolic;Metabolism;metabolomics;microbial;microbial community;Microbiology;microbiome;microbiome research;microbiota;microbiota composition;mitochondrial autophagy;Mucosal Immunity;Mus;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;obese person;Obesity;obesity development;obesity prevention;Oklahoma;Outcomes Research;Oxygenases;Pathway interactions;Pattern;Pigments;Plasma;Play;Prediabetes syndrome;prevent;Production;programs;Property;Public Health;Recommendation;Research;Research Project Grants;response;Role;single-cell RNA sequencing;systemic inflammatory response;Technology;Testing;Tissues;United States National Institutes of Health;Weight;Work;zeaxanthin

PROJECT_TITLE: Microbiome response to dietary carotenoids


NIH_SPENDING_CATS: Antimicrobial Resistance;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Infectious Diseases;Microbiome;Natural Products

PI_NAMEs: STUBBENDIECK, REED M (contact)

PROJECT_TERMS: Address;Aerodigestive Tract;Affect;Animals;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteria;Bioinformatics;Biological Assay;Biology;Cancer Patient;cancer therapy;candidate identification;Chemistry;Clinical;Coculture Techniques;commensal bacteria;commensal microbes;comparative;comparative genomics;Core Facility;Development;drug discovery;Environment;ESKAPE pathogens;Essential Amino Acids;experience;Exposure to;Face;fitness;Gene Cluster;Genetic;Genome;genome sequencing;Genomics;Genus staphylococcus;Goals;Growth;Human;Human Microbiome;human pathogen;Immune system;Immunosuppression;Impairment;In Situ;In Vitro;Infection;Infrastructure;innovation;Invaded;Lactobacillus;Lead;Mass Spectrum Analysis;Mediating;Metabolic;Metabolism;metabolome;metabolomics;Microbe;microbiome;microbiome components;microbiome research;microbiome therapeutics;Modern Medicine;Molecular;multi-drug resistant pathogen;mutant;Nasal cavity;Natural Products;NMR Spectroscopy;Nose;novel;novel therapeutics;Nutrient;Oklahoma;Operative Surgical Procedures;Opportunistic Infections;opportunistic pathogen;Oral;Organism;pathogen;pathogen exposure;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;Plants;Positioning Attribute;Process;Production;Research;Research Project Grants;Respiratory System;response;Risk Factors;screening;secondary infection;secondary metabolite;Shapes;Societies;Soil;Specimen;System;Testing;Therapeutic;Toxic effect;urogenital tract;Vitamins;Work

PROJECT_TITLE: Characterizing Pathogen-Mediated Production of Secondary Metabolites in the Human Aerodigestive Tract Microbiome


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Microbiome;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prescription Drug Misuse;Substance Misuse

PI_NAMEs: VAZQUEZ SANROMAN, DOLORES BEATRIZ (contact)

PROJECT_TERMS: addiction;Adolescence;Adolescent;Adult;Affect;age difference;Alcohols;Animal Model;Animals;Area;Attenuated;Behavior;Behavioral Symptoms;Bioinformatics;Brain;brain behavior;Brain-Derived Neurotrophic Factor;career;Chronic;Cocaine;Codon Nucleotides;cognitive function;Data;Dependence;Development;Disease;Drug Addiction;drug seeking behavior;dysbiosis;Etiology;experience;Extramural Activities;Family;fecal transplantation;functional outcomes;Funding;Future;gastrointestinal function;Gastrointestinal tract structure;Genes;Genetic Polymorphism;Goals;gut microbiome;gut microbiota;gut-brain axis;Human;in vivo Model;innovation;interest;Intervention;Knock-in;Knowledge;Kynurenine;Learning;Link;Liquid Chromatography;Mental disorders;Metabolic;metabolome;metabolomics;microbial;Microbiology;microbiome;microbiome alteration;microbiome research;microbiota;microbiota composition;Modeling;Mus;Neurobiology;neurodevelopment;neuropsychiatric disorder;neurotrophic factor;Oklahoma;Opiate Addiction;Opioid;opioid abuse;opioid exposure;opioid use;opioid use disorder;opioid withdrawal;Oral;Outcome;Oxycodone;oxycodone self-administration;Pathway interactions;Pharmaceutical Preparations;Play;Population;prevent;programs;Public Health;Rattus;Relapse;Research;Research Personnel;Research Project Grants;research study;Research Support;response;RNA;Role;Sampling;Self Administration;Serum;Sex Differences;Shotguns;Single Nucleotide Polymorphism;Sodium Butyrate;Substance abuse problem;Substance Use Disorder;success;tandem mass spectrometry;Therapeutic;translational potential;Transplantation;transplantation therapy;Tryptophan;United States;United States National Institutes of Health;Variant;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: The adolescent microbiome-gut-brain axis as a potential target in opioid abuse disorders


PROJECT_TITLE: Anaerobic Core Remodeling Project


ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE To address the national need of increasing diversity in our biomedical workforce, the UIC Portal to Biomedical Research Careers PREP (UIC PBRC-PREP) will provide recent underrepresented baccalaureate science degree graduates with an intensive research experience and professional development in the biomedical sciences. This program will prepare these scholars for admission to and success in biomedical PhD or dual degree programs, with the long-term goal that these individuals join the nation’s biomedical workforce as research scientists.

PI_NAMEs: ALFONSO, AIXA ;FEDERLE, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Academic achievement;Address;Admission activity;Area;aspirate;Awareness;Biomedical Research;Biotechnology;candidate identification;career;Career Choice;career development;Chicago;cohort;Collaborations;Communication;Communities;community building;Critical Thinking;Critiques;Degree program;Development;Development Plans;Doctor of Pharmacy;Doctor of Philosophy;Evaluation;experience;Faculty;falls;Feedback;Foundations;Funding;Goals;Graduate Degree;graduate school;graduate student;Illinois;improved;Individual;interest;Interview;Journals;Leadership;Learning;Letters;Manuscripts;meetings;member;Mentors;minority student;Mission;Monitor;Motivation;Oral;oral communication;Outcome;Paper;peer coaching;Personal Satisfaction;Population;Population Heterogeneity;Postdoctoral Fellow;posters;Process;programs;Recommendation;Recording of previous events;recruit;Reproducibility;Research;Research Ethics;Research Personnel;Science;science education;Scientist;Self Perception;skill acquisition;skills;Students;success;Thinking;Time;Training;undergraduate student;Underrepresented Populations;Universities;Visit;Writing

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE: Pediatric AML is a heterogenous group of myeloid neoplasms with over 20 distinct molecular subtypes, many of which are associated with a poor response to chemotherapy, yet the majority of these subtypes lack robust model systems for the identification of therapeutic vulnerabilities. We will develop a series of models of high- risk pediatric AML using both human and murine approaches that capture disease heterogeneity with extensive transcriptomic, epigenomic and proteomic credentialing against our large collection of primary samples, exploiting the unique expertise of each research team in this multi-PI proposal. The successful completion of these studies will nominate new model systems for rare pediatric AML subtypes that can be used by the scientific community to develop new therapeutics or establish mechanistic insights.

PI_NAMEs: KLCO, JEFFERY M;MAGEE, JEFFREY ALAN (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acceleration;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adolescent;Age;age related;Biological Models;Biology;Cancer Patient;CBFA2T1 gene;Cells;chemotherapy;Child Health;Childhood Acute Myeloid Leukemia;Chimeric Proteins;Clinical;Clinical Trials;Collection;Communities;Complex;Cord Blood Hematopoietic stem cells;Cord Blood stem cells;Credentialing;Data;Development;Disease;disease heterogeneity;disorder subtype;driver mutation;drug sensitivity;Engineering;epigenome;epigenomics;fetal;Fusion Oncogene Proteins;Future;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic approach;Genetic Enhancer Element;Genetic Heterogeneity;Genetic Transcription;Genetically Engineered Mouse;Genomics;Genotype;Goals;high risk;Histones;Human;Human Cell Line;human model;Immunodeficient Mouse;improved;In Vitro;induced pluripotent stem cell;Infrastructure;innovation;insight;Institution;interdisciplinary approach;Investigation;leukemia;Libraries;Malignant Childhood Neoplasm;medical schools;MLL gene;Modeling;molecular subtypes;mouse model;Mus;Mutation;Myeloproliferative disease;novel;novel strategies;novel therapeutics;NUP214 gene;NUP98 gene;Oncoproteins;Outcome;Pathogenicity;patient derived xenograft model;patient population;Patients;Pattern;Personal Satisfaction;Phase I Clinical Trials;Phosphorylation;pre-clinical;Preclinical Drug Development;Principal Investigator;programs;Property;protein expression;Proteome;Proteomics;Qualifying;rational design;Recurrence;Research;Research Personnel;Resources;response;risk stratification;RUNX1 gene;Saint Jude Children's Research Hospital;Sampling;Series;skills;Specimen;Supportive care;targeted treatment;Technology;Therapeutic;transcription factor;transcriptome sequencing;transcriptomics;Treatment Protocols;Universities;Variant;Viral;Washington

PROJECT_TITLE: Cross-species development and credentialing of pediatric AML models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-E (55)]


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

ORG_CITY: BIDDEFORD

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NEW ENGLAND

ORG_STATE: ME

PHR: Dysfunction in cell signaling is a fundamental driver of human disease, and our ability to optimize healthy, pain-free aging and find new treatments for neurodegenerative and metabolic diseases requires a broad understanding of the way cells communicate. The Center for Cell Signaling Research will build critical research infrastructure and support the research programs of junior investigators to meet these contemporary clinical challenges.

PI_NAMEs: MOLLIVER, DEREK C (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Address;Advisory Committees;Afferent Neurons;Aging;Animal Behavior;Benchmarking;Biochemical;Biochemistry;Biocompatible Materials;Bioenergetics;Biological;Biomedical Research;bone;Cell Communication;Cell Line;Cells;Centers of Research Excellence;chronic pain;Chronic stress;Clinical;Collaborations;college;Communication;Complement;Consultations;Contract Services;Core Facility;cost;Dedications;Defect;Development;Disease;Elastin;Ensure;experience;Faculty;Faculty Recruitment;faculty support;FRAP1 gene;Functional disorder;Functional Imaging;Funding;Genetic Transcription;Health;healthy aging;Histology;Human;human disease;Human Resources;Image;Immune;Immunology;Impaired wound healing;In Vitro;Inflammation;innovation;Institution;instrumentation;Investments;Laboratories;Leadership;Maine;Mentors;Mentorship;Metabolic Diseases;Metabolism;mimetics;multidisciplinary;Neurodegenerative Disorders;Neuroglia;Neurosciences;New Hampshire;Occupational activity of managing finances;Office of Administrative Management;Osteoblasts;Osteoclasts;Osteoporosis;Pain;Pain Free;Pathway interactions;Performance;Peripheral;Phase;Pilot Projects;Polymers;Positioning Attribute;Process;Program Development;programs;Property;Proteins;Qualifying;recruit;Regulation;Research;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;scaffold;Sensory;Services;Signal Transduction;sound;Specific qualifier value;Structure;success;synergism;System;Talents;tenure track;Time;Training;Transfection;Tuberous Sclerosis;Universities;Vascular Endothelial Growth Factors;Vascular System

PROJECT_TITLE: UNE Center for Cell Signaling Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-3 (C1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Advisory Committees;Arts;Benchmarking;career development;Centers of Research Excellence;Collaborations;college;Communication;Consultations;Continuing Education;Core Facility;Department chair;Development;Development Plans;Eligibility Determination;Ensure;Equipment;Evaluation;Evaluation Research;Excision;Faculty;Feedback;Funding;Goals;Grant;Heart;Institution;Laboratories;Lead;Leadership;Manuscripts;meetings;member;Mentorship;Monitor;Osteopathic Medicine;Pain Research;Performance;Phase;Pilot Projects;Positioning Attribute;Preparation;Process;Program Research Project Grants;programs;Recommendation;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;response;Science;Series;Services;Signal Transduction;success;symposium;synergism;tenure track;Time;Training;Universities;Wages;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: CAO, LING  (contact)

PROJECT_TERMS: Aging;Biochemical Process;Bioenergetics;Biological;Biological Assay;Biosensor;Cell Communication;Cell Culture Techniques;Cell Line;Cell model;Cell Physiology;cell type;Cells;cellular imaging;Centers of Research Excellence;Collaborations;Communication;Consultations;Contract Services;Core Facility;cost;Data Analyses;design;Development;Emerging Technologies;Ensure;Equipment;equipment acquisition;Evaluation;Experimental Designs;Faculty;Fluorescence;Functional Imaging;Funding;Future;Gel;Goals;Growth;imager;improved;In Vitro;Institution;instrumentation;interest;Investigation;Laboratories;Maine;Mass Spectrum Analysis;Medical;member;Metabolism;method development;Mission;model development;Molecular;New England;operation;Pain Research;Pathway interactions;Performance;Preparation;prevent;Procedures;Program Research Project Grants;programs;Protein Analysis;protocol development;Reader;recruit;Research;research facility;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Sampling;Series;Services;Signal Transduction;skills;stable cell line;Stress;success;symposium;System;Techniques;technology/technique;Time;Training;Training Programs;transcriptome sequencing;Transfection;Universities;Work

PROJECT_TITLE: In Vitro Analytical Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Regenerative Medicine;Wound Healing and Care

PI_NAMEs: BALOG, EVA ROSE MURDOCK (contact)

PROJECT_TERMS: Acceleration;Acute;acute wound;Aging;Amputation;angiogenesis;Angiogenesis Inhibitors;Angiogenic Factor;Bandage;Binding;Biochemical;Biocompatible Materials;Biological;biomaterial compatibility;biomaterial development;Biopolymers;Biotechnology;Blood flow;blood vessel development;Blood Vessels;cell behavior;Cell Communication;cell type;Cells;Cessation of life;Chemistry;Chronic;chronic wound;Clinical;clinical application;clinical material;clinical translation;Coculture Techniques;Confusion;Dangerousness;Data;design;Development;Diabetes Mellitus;diabetic;Drug Targeting;Elastin;Elderly;Endothelial Cells;Engineering;Environment;Event;experimental study;Exposure to;extracellular;Failure;Future;Genetic Engineering;Goals;Growth;Growth Factor;Growth Factor Receptors;healing;Health Care Costs;Homologous Gene;Hydrogels;Immune response;Impaired healing;Impaired wound healing;Impairment;improved;In Vitro;in vivo;infection risk;Inflammation;Inflammatory Response;injured;innovation;insight;Journals;KDR gene;Knowledge;Lead;Ligands;Macrophage;Mechanics;Mediating;Methods;migration;mimetics;Modeling;Morbidity - disease rate;mouse model;nano;neovascularization;next generation;novel;Obesity;particle;Pathway interactions;Pattern;Peer Review;Peptides;peptidomimetics;Persons;Pharmaceutical Preparations;phosphoproteomics;Phosphorylation;PIK3CG gene;Play;Polymers;Population;Postoperative Pain;Process;Proliferating;Property;Publishing;Quality of life;Reagent;receptor;recruit;Regenerative Medicine;Repression;Reproducibility;Research;response;revascularization;Risk Factors;Role;scaffold;self assembly;Signal Transduction;Site;Skin wound healing;stem cells;Surface;Surgical incisions;System;Testing;Therapeutic;therapy development;Tissue Engineering;tissue regeneration;tissue repair;Tissues;tool;Topical Antibiotic;treatment response;Validation;Vascular Endothelial Growth Factor B;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factors;Vegf inhibition;wound;wound healing;Wound healing therapy;Wound models

PROJECT_TITLE: Project 1 - Balog


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Osteoporosis

PI_NAMEs: BECKER, KATHLEEN A (contact)

PROJECT_TERMS: aging related disease;Alternative Therapies;Binding;bone;Bone Density;bone mass;bone metabolism;Bone necrosis;bone preservation;bone quality;Bone remodeling;Bone Resorption;bone turnover;Cell Physiology;Cells;cost;Critical Pathways;Data;design;Development;Event;experimental study;extracellular;Family;Fracture;Future;Genes;Goals;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;high risk;Homeostasis;hormonal signals;In Vitro;in vivo;innovation;Jaw;Knowledge;Lead;Ligands;Mass Spectrum Analysis;Mediating;mineralization;Molecular;Monomeric GTP-Binding Proteins;mouse model;Nervous System;new therapeutic target;novel;osteoblast differentiation;Osteoblasts;Osteoclasts;Osteogenesis;Osteoporosis;Pathway interactions;Patient Compliance;Patients;Phosphorylation;Play;prevent;Proteins;PTH gene;Recommendation;Regulation;Research;rho;rho GTP-Binding Proteins;Risk Factors;Role;Route;Safety;side effect;Signal Pathway;Signal Transduction;Signaling Protein;societal costs;stem cells;subcutaneous;targeted treatment;Testing;Therapeutic;therapeutic target;transcriptome sequencing;Transgenes;WNT Signaling Pathway;Work

PROJECT_TITLE: Project 2 - Becker


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Lung;Lymphatic Research;Nutrition;Pediatric;Pediatric Cancer;Rare Diseases;Tuberous Sclerosis;Women's Health Research

PI_NAMEs: FILIPPAKIS, CHARILAOS  (contact)

PROJECT_TERMS: Acceleration;Actins;Address;Age;Angiomyolipoma;Autophagocytosis;Biological Assay;Body System;Brain Neoplasms;Catabolism;Cell Death;Cell Proliferation;Cells;Cellular Metabolic Process;Clinic;Clinical;clinically relevant;Colorectal Cancer;Cyst;Cystic kidney;Cystic Kidney Diseases;Cytostatics;cytotoxic;Data;detection of nutrient;Disease;Disease remission;DNA;drug use screening;enzyme pathway;Enzymes;Essential Amino Acids;extracellular;FDA approved;FRAP1 gene;Genetic;Glucose;Glutamine;Growth;Heart Neoplasms;high-throughput drug screening;Homeostasis;Hyperactivity;imaging approach;in vivo;Individual;Inhibition of Cell Proliferation;inhibitor;insight;Kidney;Kidney Neoplasms;Knowledge;Kynurenine;Lesion;Libraries;Link;Lipids;Loss of Heterozygosity;Lung;Lung Neoplasms;Lymphangioleiomyomatosis;Lysosomes;macromolecule;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolic;Metabolism;Molecular;mouse model;mRNA Expression;Mutation;nano-string;new therapeutic target;novel;novel strategies;Nucleic Acids;Nutrient;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;Play;Pre-Clinical Model;Process;Proliferating;Protein Biosynthesis;Proteins;Proteomics;pulmonary function;pulmonary function decline;Reporter;Research;response;RNA;Role;Signal Transduction;Sirolimus;Skin;Supplementation;System;Therapeutic;therapeutic evaluation;therapeutic target;Trace Elements Nutrition;trafficking;transcription factor;transcriptomics;Transgenic Model;Tryptophan;Tryptophan Metabolism Pathway;Tryptophanase;TSC1/2 gene;TSC2 gene;Tuberous Sclerosis;tumor;tumorigenesis;Up-Regulation;uptake;Withholding Treatment;Xenograft procedure

PROJECT_TITLE: Project 3 - Filippakis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects

PI_NAMEs: QUEME COBAR, LUIS FERNANDO (contact)

PROJECT_TERMS: Acute;Adult;Affect;Afferent Neurons;Animal Behavior;Animals;Anxiety;Behavior;Behavioral;Bioinformatics;Calcium;candidate identification;Cell Culture Techniques;Cells;Centers of Research Excellence;Chronic;chronic constriction injury;chronic musculoskeletal pain;chronic pain;Chronic stress;clinically significant;Communication;Culture Media;Data;Development;Electrophysiology (science);environmental enrichment for laboratory animals;Event;experimental study;Exposure to;Fibromyalgia;flexor digitorum brevis;Future;Gene Expression;glial activation;glial cell development;Glial Fibrillary Acidic Protein;Health;High Prevalence;Housing;Hyperalgesia;Hypersensitivity;Image;In Vitro;Injury;instrumentation;Ischemia;Knowledge;Lead;Life;Ligands;Link;mechanical allodynia;Mechanics;Mediating;Mediator;Mentors;Modeling;mouse model;Mus;Muscle;Muscle Development;Muscle function;Musculoskeletal;Musculoskeletal Development;Musculoskeletal Pain;Myalgia;Nature;Nerve;nerve injury;Neuroglia;neuronal cell body;Neurons;Neuropathy;Nociception;Nociceptive Stimulus;Nociceptors;novel;Pain;pain chronification;pain perception;Peripheral;pharmacologic;Phenotype;Physical Stimulation;Physiological;Play;Population;Postoperative Pain;Poverty;Pre-Clinical Model;Preparation;Process;programs;receptor;Reperfusion Injury;Reporting;Research;research and development;Research Personnel;response;Risk Factors;Rodent Model;Role;Signal Transduction;Signaling Molecule;Spinal Cord;Spinal Ganglia;Stress;stressor;Supporting Cell;Surgical incisions;Testing;Thinness;Time;tissue injury;Tissues;transcriptome sequencing;transcriptomics;Withdrawal

PROJECT_TITLE: Project 4 - Queme


PROJECT_TERMS: Anatomy;Architecture;Astronomy;Award;Biological;Biomedical Research;Cell Culture Techniques;Centers of Research Excellence;college;Contracts;Core Facility;cost;design;Educational process of instructing;Ensure;Equipment;experimental study;Faculty;Faculty Recruitment;Floor;Funding;Health Sciences;Histology;Housing;Ice;Image;In Vitro;Incubators;Individual;innovation;Institution;instrumentation;Intention;Laboratories;Laboratory Research;Location;Maine;medical schools;New England;Osteopathic Medicine;Plumbing;prevent;programs;recruit;Research;research facility;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Safety;Signal Transduction;Site;Specific qualifier value;square foot;success;synergism;System;teaching laboratory;Universities;Water;Work

PROJECT_TITLE: Alterations and Renovations


NIH_SPENDING_CATS: Genetics

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE DNA genetic material (gene) is converted into RNA molecules that then generate the proteins required for life and these programs need to be well coordinated during development to maintain health. One regulatory mechanism of gene expression is known as “alternative splicing”, which allows individual genes to generate multiple proteins with potential different functions. Our research program will investigate the functions of alternative splicing regulation in the organization of the cytoskeleton, transcription, and local translation and we expect to provide conceptual advances to understand how these functions contribute to normal physiology and how their disruption leads to pathological conditions.

PI_NAMEs: GIUDICE, JIMENA  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Academia;Alternative Splicing;Architecture;Area;Cardiac Myocytes;Cell Differentiation process;Cell Nucleus;Cell Physiology;Cells;Chromatin;Creativeness;Curiosities;Cytoplasm;Cytoskeletal Modeling;Cytoskeleton;Defect;Development;DNA;Epigenetic Process;equity, diversity, and inclusion;Eukaryota;flexibility;frontier;Gene Expression;Genes;Genetic Materials;Genetic Transcription;genome-wide analysis;Health;Human;Individual;interest;Life;Maintenance;Mechanics;Membrane;Mentors;Muscle Fibers;Myopathy;National Institute of General Medical Sciences;Neurons;Organ;organ growth;Pathologic;Phase;physiologic model;Physiology;programs;protein function;Proteins;Regulation;Research;RNA;RNA Processing;RNA Splicing;Role;Scientist;Societies;synergism;Time;Tissues;trafficking;Training;Transcript;transcription factor;Transcriptional Regulation;Translational Regulation;Translations;Tube;Variant;Woman

PROJECT_TITLE: When alternative splicing meets cytoskeleton organization, local translation, and transcription regulation

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative The proposed study aims to examine the relationship between multiple forms of discrimination and allostatic load, a condition characterized by the dysregulation of physiological activity across multiple systems in the body. Utilizing data from three large, population-based cohort studies, the study will assess the associations between multiple forms of discrimination (such as neighborhood and interpersonal) with allostatic load; examine the extent to which the "Conserved Transcriptional Response to Adversity" (CTRA) gene expression mediates the relationship between discrimination and allostatic load, as well as evaluate the moderating effect of social integration on these associations. By defining the relationship between multiple forms of discrimination and allostatic load, the study aims to provide a foundation for increasing the efficacy of prevention efforts and treatment to reduce allostatic load and Black-White disparities in allostatic load.

PI_NAMEs: CUEVAS, ADOLFO  (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Address;Adolescent;Adult;Affect;age group;Aging;allostatic load;Area;Biological;Biological Aging;Biological Process;Biology;Black American;Black race;black/white disparity;Buffers;burden of chronic illness;Cardiovascular system;caucasian American;Cell Physiology;Chronic Disease;Clinical;cohort;Cohort Studies;Communities;Data;Data Set;Development;Diabetes Mellitus;Diet;Dimensions;Discrimination;Disease;Disparity;Epidemiology;ethnic disparity;experience;Exposure to;Foundations;Future;Gene Expression;Genetic Transcription;glucose metabolism;Goals;Health;Health and Retirement Study;health difference;health disparity;health inequalities;Health Policy;Heart Diseases;human old age (65+);Individual;Inflammation;Inflammatory;Intervention;Knowledge;Leukocytes;Life Cycle Stages;Light;Link;lipid metabolism;Longitudinal Studies;Measures;Mediating;Methods;middle age;Molecular;Molecular Genetics;mortality disparity;National Longitudinal Survey of Adolescent to Adult Health;Neighborhoods;older adult;Outcome;Pathway interactions;Physiological;Play;Population;population based;Populations at Risk;premature;Prevalence;Prevention;Process;protective factors;Psychology;psychosocial;Race;racial difference;racial disparity;racial health disparity;Reduce health disparities;Research;Research Design;Research Personnel;response;Risk;Risk Factors;Role;secondary analysis;Skin;Social Environment;social integration;Socioeconomic Status;Sociology;statistics;Stress;stressor;Stroke;Subgroup;System;Techniques;Testing;Transcript;United States;United States National Institutes of Health;viral RNA;Work

PROJECT_TITLE: Applying a life course approach to assess the impact of neighborhood and interpersonal discrimination on allostatic load.

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative: Overall Center Organization and Management Plan The Nebraska Center for Heart and Vascular Research Phase I COBRE will build and expand the capacity of University of Nebraska Medical Center to conduct innovative and groundbreaking heart and vascular disease (HVD) research by growing HVD resources and funded HVD-focused faculty in an environment of collaboration that has the capacity to improve heart and vascular disease outcomes across Nebraska and beyond.

PI_NAMEs: GUNDRY, REBEKAH L. (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Accounting;Address;Adult;Animals;Applications Grants;Area;Biological Assay;biomedical referral center;Blood Vessels;Cardiovascular system;career;career development;Cause of Death;Cell Physiology;Cell Separation;Centers of Research Excellence;Cessation of life;Childhood;cohort;Collaborations;college;Complex;Country;Data;data acquisition;Data Analyses;Development;Disease;Disease Outcome;Education;Educational workshop;Ensure;Environment;Equipment;Evaluation;Faculty;faculty research;Financial Support;Focus Groups;Funding;Funding Opportunities;Future;Glycobiology;Goals;Grant;Great Plains;Health;health disparity;Heart;heart cell;Heart Diseases;Heart failure;Heart Transplantation;Hospitalization;Human;Human Resources;Image-Guided Surgery;Immunoassay;improved;Infrastructure;infrastructure development;innovation;Institution;Joints;K-Series Research Career Programs;Laboratory Research;Lead;Medical center;Medicine;member;Mentors;Mentorship;Midwestern United States;Mission;Molecular;multidisciplinary;Nebraska;Operative Surgical Procedures;Outcome;Patient-Focused Outcomes;peer coaching;Phase;Preparation;Productivity;Program Description;programs;Proteins;Proteomics;Protocols documentation;Provider;recruit;Research;research and development;Research Design;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Research Project Summaries;Resources;sabbatical;Series;Services;Specimen;success;surgical service;Technology;Training;transcriptomics;United States;United States National Institutes of Health;Universities;Vascular Diseases;voucher;Western Blotting;Writing


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease

PHR: PROJECT NARRATIVE: ADMINISTRATIVE CORE Not applicable

PROJECT_TERMS: Advisory Committees;Area;Basic Science;Biological Assay;Biomedical Research;Blood Vessels;career;Centers of Research Excellence;Clinical;Clinical Research;Collaborations;collaborative environment;college;Communication;Country;Data Analyses;Development;Discipline;early-career faculty;Education;Effectiveness;Ensure;Environment;Ethics;Evaluation;Faculty;Feedback;Focus Groups;Funding;Goals;Grant;Growth;Health;Heart;Heart Diseases;improved;Individual;Infrastructure;Knowledge;Leadership;Learning;Manuscripts;Medical center;Medicine;member;Mentors;multidisciplinary;Nebraska;Occupational activity of managing finances;organizational structure;Outcome;peer;peer coaching;Pilot Projects;Population Research;Program Evaluation;Program Research Project Grants;programs;recruit;Reproducibility;Research;Research Design;Research Personnel;Research Project Summaries;Resources;Secure;Series;success;System;Talents;Therapeutic;Training;Translational Research;United States National Institutes of Health;Universities;Update;Vascular Diseases;voucher;Writing

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease

PHR: PROJECT NARRATIVE: BIOASSAY CORE Not applicable

PI_NAMEs: HACKFORT, BRYAN T (contact)

PROJECT_TERMS: Address;Applications Grants;Basic Science;Bioinformatics;bioinformatics pipeline;bioinformatics tool;Biological Assay;Blood;Blood Vessels;Cell Separation;Cells;Cellular Assay;Centers of Research Excellence;Clinical;Clinical Data;Clinical Sciences;Collaborations;Complex;Computer software;Computers and Advanced Instrumentation;computing resources;Consultations;Data;data acquisition;Data Analyses;Disease;Disease Marker;Educational workshop;Effectiveness;Equipment;Experimental Designs;experimental study;Faculty;Family suidae;Funding;Future;Genetic;Genomics;Glycobiology;Glycoproteins;Goals;Grant;Guidelines;Hand;Heart;heart cell;Heart Diseases;Human;Human Resources;Immunoassay;Individual;Infrastructure;Institution;instrumentation;Legal patent;Mass Spectrum Analysis;Measurement;Measures;Mentors;Metabolic;Methodology;Mission;Modification;Molecular;multiple omics;Nebraska;new technology;Paper;Pathology;Pathway interactions;Peer Review;Physiological;Physiology;Post-Translational Protein Processing;Preparation;Procedures;Process;programs;Protein Analysis;Proteins;Protocols documentation;Publications;Reagent;recruit;Registries;Regulation;Research;Research Design;Research Personnel;Research Project Grants;Research Project Summaries;Resources;Sampling;Scientist;Services;skills training;Specimen;Speed;Standardization;success;System;Technical Expertise;Technology;Tissues;tool;Training;transcriptomics;trend;Universities;Vascular Diseases;Western Blotting;Work

PROJECT_TITLE: Bioassay Core


NIH_SPENDING_CATS: Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease

PHR: PROJECT NARRATIVE: ALTERATION AND RENOVATION PROJECT Not applicable

PI_NAMEs: BRADFIELD, JOHN F (contact)

PROJECT_TERMS: Angiography;Animal Model;Animals;arm;Blood Vessels;Cardiac;Cardiovascular Surgical Procedures;Cardiovascular system;Centers of Research Excellence;Chronic;comparative;design;detector;Education;Equipment;Family suidae;Funding;Goals;Heart;Image;Image-Guided Surgery;improved;Infrastructure;Joints;Medicine;Mentors;Monitor;Names;Nebraska;Operative Surgical Procedures;Phase;porcine model;Procedures;programs;radiological imaging;Research;Research Personnel;Research Project Grants;Research Project Summaries;Resolution;Roentgen Rays;Shapes;Source;Stents;success;Super C resin;therapeutic evaluation;Time;United States National Institutes of Health;Update;X-Ray Medical Imaging

PROJECT_TITLE: Joint Cardiovascular Research Lab Alteration and Renovation


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Heart Disease;Physical Activity

PHR: PROJECT NARRATIVE: ALONSO PROJECT Not applicable

PI_NAMEs: ALONSO, WINDY WILLIAMS (contact)

PROJECT_TERMS: Acute;acute stress;Adult;Anxiety;Basic Science;Biological Assay;Biological Markers;Biology;Blood Vessels;Cardiopulmonary;Cardiovascular system;career;Categories;Centers of Research Excellence;Cessation of life;Characteristics;Clinic;Clinical;Clinical Chemistry;clinical diagnostics;Clinical Research;Clinical Trials;comorbidity;Complex;Consensus;Consent;cytokine;Data;Deceleration;demographics;depressive symptoms;diagnostic strategy;Dyspnea;Echocardiography;Education;EFRAC;Exclusion;Exercise;Exercise Test;Fatigue;Fortification;Foundations;Functional disorder;global health;Goals;Grant;Heart;Heart Diseases;Heart failure;heart failure with reduced ejection fraction;Hospitalization;human old age (65+);Image;improved;Inflammation;Inflammatory;instrument;Knowledge;Laboratories;Link;Malignant Neoplasms;Measures;Medical Records;Medicine;Mentors;Mitral Valve;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Nebraska;Nurses;Organ;Output;Oxygen Consumption;Pain;Patient Outcomes Assessments;Patients;Pattern;personalized diagnostics;Phenotype;Physical Function;Plasma;preservation;pro-brain natriuretic peptide (1-76);Procedures;programs;Public Health;Quality of life;recruit;Research;Research Personnel;Research Project Grants;Resources;Rest;Sampling;Science;Scientist;skills;Sleep disturbances;Stress;Survival Rate;Swelling;symptom science;Symptoms;Syndrome;Technology;Testing;Training;training project;Treatment Failure;treatment strategy;Troponin;Variant;Vascular Diseases;Venipunctures

PROJECT_TITLE: Using Patient-Reported Outcomes, Inflammatory Profiles, and Cardiovascular Phenogroups to Expand the Definition of Heart Failure with Preserved Ejection Fraction


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Congenital Structural Anomalies;Heart Disease;Pediatric;Rare Diseases

PHR: PROJECT NARRATIVE: COOK PROJECT Not applicable

PI_NAMEs: COOK, JASON RHEDE (contact)

PROJECT_TERMS: Acute;Age Months;Angiotensin II Type 1 Receptor Blockers;Animals;Aorta;aorta constriction;Aortic Aneurysm;ascending aorta;Biological Availability;Blood Vessels;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;career development;Caring;Cells;Centers of Research Excellence;Chemotaxis;Clinical Management;Complex;Connective Tissue Diseases;cooking;cytokine;Development;Dilated Cardiomyopathy;Dissection;Elastin;Endothelial Cells;Event;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;FBN1;Foundations;Funding;Growth;Growth Factor;Heart;Heart Diseases;Heart failure;Hereditary Disease;Homeostasis;Immunofluorescence Immunologic;improved;Incidence;Inflammation;Inflammatory;Inherited;interest;Interleukin-6;Investigation;Knockout Mice;Losartan;Macrophage;Maps;Marfan Syndrome;Matrix Metalloproteinases;Mediating;Mentors;Microfibrils;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;Myocardial dysfunction;Nebraska;new therapeutic target;paracrine;Pathway interactions;Patients;Persons;pharmacologic;Physiology;Population;Postoperative Period;pressure;Publications;Receptor Activation;Receptor, Angiotensin, Type 1;Regulation;Research;research and development;Research Personnel;response;Role;Rupture;Secondary to;Signal Transduction;Stress;Structure;Surgeon;Testing;Thoracic Aortic Aneurysm;Time;Tissue Sample;Tissues;transcriptome sequencing;Transforming Growth Factor beta;Translational Research;Vascular Diseases;Vascular Smooth Muscle;Wild Type Mouse;Work

PROJECT_TITLE: Regulation of Cardiovascular Physiology in Marfan Syndrome


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Digestive Diseases;Heart Disease;Microbiome;Pediatric;Rare Diseases

PHR: PROJECT NARRATIVE: SALOMON PROJECT Not applicable

PI_NAMEs: SALOMON, JEFFREY  (contact)

PROJECT_TERMS: Affect;Animal Model;Applications Grants;Automobile Driving;Bacteria;bacterial genetics;Binding Proteins;Biological;Blood Vessels;Bypass;Cardiac;Cardiac health;Cardiac Surgery procedures;Cardiopulmonary Bypass;Carrier Proteins;Centers of Research Excellence;Child;Childhood;Circulation;claudin 3;congenital heart abnormality;Data;Defect;Disease;dysbiosis;Eicosanoids;Epithelium;fatty acid-binding proteins;Feces;Functional disorder;Future;Genetic Transcription;genome sequencing;Goals;gut bacteria;gut dysbiosis;gut microbiome;Health;Heart;Heart Diseases;Homeostasis;human subject;immune activation;improved;Inflammation;Inflammatory;innovation;Intervention;intestinal barrier;intestinal epithelium;Intestinal permeability;Intestines;Investigation;Lesion;Link;lipid mediator;Lipids;Live Birth;Low Cardiac Output;Maintenance;Maps;Mass Spectrum Analysis;Measures;Mediating;microbial;microbiome;microbiome alteration;microbiome research;Modeling;Morbidity - disease rate;mortality;Nebraska;novel;Operative Surgical Procedures;organ injury;Organism;Outcome Study;palliate;Pathway interactions;patient population;Patient-Focused Outcomes;Patients;pediatric patients;Phylogenetic Analysis;Plasma;Play;porcine model;Postoperative Period;Prevention strategy;Process;Proteins;Proteobacteria;Publishing;Quality of life;repaired;Research;Risk;Role;Signal Transduction;stool sample;systemic inflammatory response;Systemic Inflammatory Response Syndrome;targeted treatment;Testing;Therapeutic Intervention;Tight Junctions;United States;United States National Institutes of Health;Vascular Diseases;Volatile Fatty Acids;whole genome

PROJECT_TITLE: Intestinal Dysbiosis Exacerbates Inflammation after Cardiopulmonary Bypass in Congenital Heart Disease


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Organ Transplantation;Transplantation

PHR: PROJECT NARRATIVE: URBAN PROJECT Not applicable

PI_NAMEs: URBAN, MARIAN  (contact)

PROJECT_TERMS: Address;Adenosine;Adenosine A3 Receptor;adenosine receptor activation;Agonist;Animals;animation;Attenuated;Blood;Blood flow;Blood Vessels;Bolus Infusion;Brain Death;Cardiac Myocytes;cardioprotection;career;Cell Separation;Cessation of life;Circulation;clinical practice;Clinical Research;Closure by clamp;Collaborations;comparison control;cooking;Data;Echocardiography;Electron Microscopy;Electron Spin Resonance Spectroscopy;Endothelial Cells;Environment;ethnic minority;experience;extracellular;Fatty Acids;Fostering;Functional disorder;Future;Generations;Genus Hippocampus;Goals;graft dysfunction;Heart;heart allograft;Heart and Lung machine;Heart Arrest;Heart failure;heart function;Heart Transplantation;hemodynamics;Hydroxylamine;improved;In Situ;Infarction;Ischemia;Kidney;Liver;Measurement;Measures;Mechanics;Mediating;Mentors;Mentorship;Metabolic;Metabolic Pathway;Mitochondria;Myocardial;Myocardial dysfunction;myocardial hypoxia;Myocardial Infarction;myocardial injury;Myocardial Ischemia;Myocardial tissue;Myocardium;Nebraska;neutrophil;Neutrophil Collagenase;Nitrates;Nitric Oxide;Nitrogen Dioxide;novel;Organ;Organ Donor;Organ Preservation;Oxygen;Pathway interactions;Patients;Perfusion;Periodicity;Peroxidases;Physiology;porcine model;post-transplant;preclinical study;preservation;pressure;Process;Production;Protocols documentation;racial minority;Reaction;Recovery;Regional Perfusion;Reperfusion Injury;Reperfusion Therapy;Research;Research Personnel;Research Support;Respiration;respiratory;Role;Scientist;Senior Scientist;Superoxides;Surgeon;Techniques;technology development;Testing;Time;Tissue Sample;Tissues;Transesophageal Echocardiography;Translating;Translations;transplant centers;Transplantation;Waiting Lists;Warm Ischemia

PROJECT_TITLE: The Role of Selective A3 Adenosine Receptors Activation in Myocardial Protection in donation After Circulatory Death Heart Transplantion


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE Depression and obesity often co-exist among middle-aged and older adults, disproportionately affecting racial and ethnic minorities, and are associated with greater cardiometabolic disease risk (e.g., diabetes), poorer treatment adherence, and worse quality of life than either condition alone. To address the lack of effective and scalable integrated treatment for these two conditions among racial and ethnic minorities, the current study will test a fully digital behavioral intervention that combines a virtual voice-based coach delivering problem-solving therapy for depression care management and a video-based intervention for lifestyle-based weight loss and increased physical activity among racial and ethnic adults aged 50-74 years. This work aligns with the National Institute on Aging’s strategic priorities to prevent multiple chronic conditions and reduce health disparities through innovative interventions to maintain health, well-being, and function.

PI_NAMEs: KANNAMPALLIL, THOMAS GEORGE;MA, JUN  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Academic Medical Centers;Accelerometer;acceptability and feasibility;active method;Address;Adult;Affect;Age;aged;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;Anxiety;anxiety symptoms;arm;Artificial Intelligence;Behavior Therapy;Behavioral;Black race;Body Weight decreased;Cardiometabolic Disease;Characteristics;Chicago;Chronic;Clinical;Clinical Trials;clinically significant;cognitive function;college;comorbid depression;comorbidity;contextual factors;COVID-19 pandemic;Data;Dementia;depressive symptoms;design;Development;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;digital;digital health;digital intervention;digital technology;Disease remission;disorder risk;Education;efficacy evaluation;efficacy testing;Electronic Health Record;Enrollment;Ensure;ethnic minority;ethnic minority population;Ethnic Origin;Evidence based intervention;experience;follow up assessment;Future;Goals;Health;health equity;health inequalities;human old age (65+);improved;innovation;integrated care;Intervention;intervention effect;intervention participants;Intervention Studies;Interview;Latino;lifestyle intervention;Loneliness;Maintenance;Managed Care;Medical;Mental Depression;middle age;Minority;Modeling;Monitor;Moods;multiple chronic conditions;National Institute on Aging;Not Hispanic or Latino;Obesity;obesity risk;older adult;Outcome;Participant;Patients;Perception;Personal Satisfaction;Persons;Physical activity;pilot test;Prediction of Response to Therapy;Prevalence;prevent;primary endpoint;primary outcome;Privacy;problem solving therapy;programs;Psyche structure;psychosocial;Public Health;Quality of life;Race;racial minority;racial minority population;Randomized;randomized, clinical trials;Reduce health disparities;reduce symptoms;Research;research and development;response;Risk;secondary outcome;Security;sex;Sleep;Social isolation;sociodemographics;Subgroup;success;Surveys;Symptoms;Tablets;Testing;Translational Research;Translations;treatment adherence;treatment effect;Trust;United States National Institutes of Health;usability;virtual;virtual coach;Voice;Waiting Lists;wearable device;Weight;Weight Gain;weight loss intervention;weight loss program;wireless;Work

PROJECT_TITLE: digital InteGrated behavioral treatmeNt for comorbid obesITy and deprEssion among racial and ethnic adults age 50 and older (IGNITE)

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Cardiovascular;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Chronic limb threatening ischemia (CLTI) patients display pathological remodeling of limb muscle that impairs walking performance, angiogenesis, and strength. We propose here to study a novel molecular pathway that links mis-regulated intercellular communication to pathological remodeling in the CLTI limb. Using modern genetic/molecular models and translational studies in already collected patient cells and tissues, these studies will provide important insights into the causes of worsened outcomes in CLTI and may lead to novel therapeutic approaches for these unfortunate patients.

PI_NAMEs: KOPINKE, DANIEL ;RYAN, TERENCE E (contact)

PROJECT_TERMS: Acceleration;Adipocytes;Adipose tissue;Agonist;angiogenesis;Angiogenic Factor;Atlases;biobank;Blood capillaries;Blood flow;Blood Vessels;Cardiovascular system;Cell Nucleus;Cells;Chronic;Cicatrix;Cilia;claudication;Clinical Trials;Communication;Coupled;Cues;Data;deep sequencing;density;Development;effective therapy;Erinaceidae;Evaluation;Event;Exhibits;experimental study;extracellular;extracellular vesicles;Failure;Fatty acid glycerol esters;Fibrosis;Foundations;Functional disorder;Future;gain of function;Gait abnormality;Gangrene;Genes;Genetic;Genetic Transcription;Growth;hemodynamics;Hindlimb;Histologic;Human;improved;Infiltration;Injury;innovation;insight;intercellular communication;Intramuscular;Ischemia;Isolated limb perfusion;Knowledge;Laboratories;Lasers;limb amputation;limb ischemia;Limb structure;Link;lipid biosynthesis;loss of function;Lower Extremity;Mass Spectrum Analysis;mesenchymal stromal cell;Modeling;Modernization;Molecular;molecular modeling;mortality;mouse model;Mus;Muscle;muscle form;Muscle function;muscle regeneration;muscle strength;Muscular Atrophy;new therapeutic target;novel;novel therapeutic intervention;Outcome;Pain;Pathologic;Pathology;Pathway interactions;patient population;Patient-Focused Outcomes;Patients;Peptides;Perfusion;Peripheral arterial disease;pharmacologic;PPARG gene;pre-clinical;prevent;primary outcome;Procedures;Process;progenitor;Recovery;Repression;Resolution;Resources;Rest;revascularization;Risk;RNA;Rodent;Role;Signal Transduction;smoothened signaling pathway;Specimen;standard of care;stem cell fate;stem cells;success;Technical Expertise;Testing;Therapeutic;therapeutic development;Time;Tissues;translational study;walking performance

PROJECT_TITLE: The role of fatty fibrosis in chronic limb threatening ischemia pathobiology

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Despite the high mortality of prostate cancer, molecular mechanisms underlying castration-resistant progression of this disease remain poorly understood. This application is designed to elucidate how mechanistically the components of oncogenic signaling pathways that are often mutated in prostate cancer cooperate to drive prostate cancer progression and how this mechanism of action can be therapeutically targeted. Findings from this application will shed new light on understanding of the molecular mechanisms of prostate cancer progression and lead to identification of new therapeutic targets for treatment of this disease.

PI_NAMEs: DOMINGO-DOMENECH, JOSEP MARIA;LOU, ZHENKUN  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: abiraterone;Agreement;American;Androgen Antagonists;androgen independent prostate cancer;Androgen Receptor;Anti-androgen Therapy;Binding;Bromodomain;Cancer Etiology;Cancer Patient;Castration;Cessation of life;Clinic;Clinical;Complex;Data;demethylation;design;Diagnosis;Disease;Disease Progression;DNA;DNA Modification Methylases;DNA Sequence Alteration;Down-Regulation;effective therapy;enzalutamide;epigenetic silencing;Exhibits;Genes;Genetically Engineered Mouse;genomic locus;Growth;Hypermethylation;Induced Mutation;inhibitor;innovation;Lesion;Malignant neoplasm of prostate;Malignant Neoplasms;MAP Kinase Gene;MAPK3 gene;MEKs;men;Metastatic Prostate Cancer;Molecular;molecular subtypes;mortality;Mus;Mutate;Mutation;new therapeutic target;next generation sequencing;novel;novel strategies;novel therapeutic intervention;Oncogenic;Pathway interactions;Patients;Phosphorylation;pre-clinical;Prostate;prostate cancer cell;prostate cancer progression;Prostate Cancer therapy;Protein Methylation;Proteins;Ras/Raf;RBX1 gene;receptor;Receptor Signaling;Receptor-Interacting Protein;Resistance;resistance mechanism;Sampling;Signal Pathway;Signal Transduction;Testing;The Cancer Genome Atlas;therapeutic target;treatment group;Tumor Biology;Tumor Suppressor Genes;tumorigenesis;ubiquitin-protein ligase;Ubiquitination;Up-Regulation

PROJECT_TITLE: Mechanism and therapeutic targeting of castration resistance in SPOP-mutated prostate cancer

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative This project will support an annual course on applications of isotope technologies to perform metabolic research in animals and humans.

PI_NAMEs: MCGUINNESS, OWEN P (contact);PARKS, ELIZABETH JANE

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: amino acid metabolism;Animal Model;Animals;Area;bench to bedside;Biomedical Research;Carbohydrates;Cells;Cellular biology;Communities;Computer software;Creativeness;Data;Data Analyses;Development;Diabetes Mellitus;Diabetic mouse;Discipline;Disease;Doctor of Philosophy;Education;Educational Activities;Educational Curriculum;Educational Materials;Educational process of instructing;energy balance;Equilibrium;experience;Experimental Designs;Faculty;Fatty acid glycerol esters;Feedback;Funding;Funding Opportunities;Genetic;Glucose Clamp;Home;Human;Hyperinsulinism;In Vitro;in vivo;Incidence;Institution;International;Investments;Isotopes;Kinetics;Knowledge;Language;lectures;Mass Spectrum Analysis;Measurement;Measures;medical schools;Mentors;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Methodology;Methods;Mission;Modeling;Modeling of Cellular Pathways;Molecular Biology;Monitor;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;nutrition;Nuts;Obesity;Organ;oxidation;Participant;Pathway interactions;Phenotype;Physicians;Procedures;programs;protein metabolism;Proteins;Protocols documentation;Radioisotopes;Regulation;Research;Research Personnel;Research Project Grants;response;Sampling;Science;Scientist;Services;skill acquisition;skills;stable isotope;Students;Techniques;Technology;theories;tool;Tracer;Training;Training Programs;United States National Institutes of Health;Universities;web site;webinar;Wood material

PROJECT_TITLE: Training in isotopic techniques for metabolic research

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE The Weill Cornell Initiative for Maximizing Student Development (Weill Cornell IMSD) will increase the number of underrepresented doctoral students who are trained to conduct exceptional research and continue as leaders in biomedical research careers. By helping to diversify the biomedical workforce, the Weill Cornell IMSD will take part in addressing the critical need to reduce racial and ethnic healthcare disparities.

PI_NAMEs: CARRASCO, YAZMIN PAULINA (contact);CESARMAN, ETHEL

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Development;Students


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative The long-range goal of the University of Chicago Initiative for Maximizing Student Development (IMSD) is to help diversify the scientific workforce. The IMSD provides research training and educational opportunities for newly admitted PhD graduate students from groups underrepresented in the biomedical and behavioral sciences until completion of the PhD. To assess the success of this endeavor, the participants’ progress is measured by quantitative metrics and skill-acquisition throughout their graduate programs and into subsequent career paths.

PI_NAMEs: PRINCE, VICTORIA E.;RICE, PHOEBE A;SCHWARTZ, NANCY B (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: The University of Chicago Initiative for Maximizing Student Development (IMSD)


NIH_SPENDING_CATS: Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: The UAB PREP Scholars Program is a postbaccalaureate research education program that provides essential training and skills required to matriculate into high quality PhD programs in biomedical science, thus with the goal of increasing diversity in the biomedical workforce.

PI_NAMEs: GAVIN, CRISTIN F;SCHNEIDER, DAVID ALAN (contact);SHACKA, JOHN J

PROJECT_TERMS: Academic support;Alabama;Area;Award;career;career networking;Classification;college;Communities;Complex;Critical Pathways;design;Development;Development Plans;Doctor of Philosophy;doctoral student;Education;education research;Ensure;Environment;Expenditure;experience;Financial Support;Funding;Goals;graduate school;graduate student;Grant;Individual;Institution;interest;International;marginalized community;matriculation;Medical;Mentors;Participant;Pathway interactions;Postbaccalaureate;Principal Investigator;Privatization;programs;Qualifying;Readiness;Research;research and development;Scholars Program;Science;self reliance;Site;skills;Students;success;Training;Training Programs;undergraduate student;Underserved Population;United States National Institutes of Health;Universities

PROJECT_TITLE: UAB PREP Scholars Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: UNIVERSITY

ORG_NAME: UNIVERSITY OF MISSISSIPPI

ORG_STATE: MS

PHR: The DIRECT (Diversifying Interdisciplinary drug and device development Research Expertise through Community building and Training) Program will recruit, prepare, and empower trainees from diverse backgrounds to successfully enter the biomedical workforce in academia, industry, legal, healthcare, government, and other biomedical sectors. The multidisciplinary program proposes rigorous, evidence-based teaching, learning, mentoring and assessment environments, as well as cohort building and career and professional development activities, that will prepare the students to become independent investigators and leaders in the drug and device development fields.

PI_NAMEs: BARNARD, MARIE  (contact);MAJUMDAR, SOUMYAJIT ;MEAD, SHAWNBODA DEANNE

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Mississippi;Universities

PROJECT_TITLE: G-RISE at The University of Mississippi


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative Parkinson disease (PD) is the second most common neurodegenerative disease with approximately 4-10 million people affected worldwide, and result in tremendous economic burden (14.4 billion/year in the United States). Neuroinflammation is a key element in the pathogenesis and progression of PD, yet the lack of specific biomarkers has hindered both targeted therapy and diagnostic imaging options. The success of this application may lead to identification of a neuroinflammation biomarker and facilitate anti-inflammation therapeutics for PD and other neuroinflammatory diseases.

PI_NAMEs: PERLMUTTER, JOEL SYNES;TU, ZHUDE  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Affect;Age;Animal Model;Anti-Inflammatory Agents;Astrocytes;Autopsy;Autoradiography;Binding;Binding Sites;Biological Markers;Brain;Brain Diseases;Brain Injuries;Brain region;brain tissue;brain volume;Central Nervous System;comparison control;Contralateral;Data;Development;Diagnosis;Diagnostic Imaging;Disease;dopaminergic neuron;dosimetry;Economic Burden;Elements;Enzyme-Linked Immunosorbent Assay;Euthanasia;Family;Family member;Female;frontal lobe;Goals;healthy volunteer;Human;Image;Immunofluorescence Immunologic;In Vitro;Inflammation;Inflammatory;Inflammatory Response;Injury;interest;Intracarotid;Intracarotid Infusion;Ipsilateral;Lesion;longitudinal positron emission tomography;Lysophospholipids;Macaca;Magnetic Resonance Imaging;male;Measures;Membrane;Microglia;motor behavior;motor symptom;Movement Disorder Society Unified Parkinson's Disease Rating Scale;MPTP Poisoning;MRI Scans;Multiple Sclerosis;multiple sclerosis patient;Names;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurons;neuroprotection;Neurotoxins;nonhuman primate;Oligodendroglia;Parkinson Disease;Parkinsonian Disorders;Participant;Pathogenesis;Patients;Persons;Play;Positron-Emission Tomography;preclinical study;Quantitative Autoradiography;radioligand;radiotracer;receptor;Reporting;response;Role;safety study;Scanning;sex;Signal Transduction;Site;specific biomarkers;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;Stains;success;targeted treatment;Testing;Therapeutic;therapeutic development;therapeutic target;Tissues;tool;Tracer;United States;uptake;Validation;white matter

PROJECT_TITLE: Investigate neuroinflammation in the brain of PD using S1P1 radioligands

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Nutrition;Obesity;Physical Activity

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: PROJECT NARRATIVE  The “Clinical Methods for Nutrition and Obesity Research” course will be an annual, 5-day course to train postdoctoral fellows and early career faculty on gold standard and cutting-edge research methodologies for conducting obesity and nutrition related research at Pennington Biomedical Research Center in Baton Rouge, LA. This course will also allow us to train the next generation of scientists from around the country, particularly those from underrepresented groups in the biomedical sciences, and to foster collaborations between Louisiana scientists and others across the country who are interested in researching obesity and nutrition.

PI_NAMEs: LINDSLY, CASIE ;REDMAN, LEANNE MAREE (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Address;Adult;Affect;biobank;Biomedical Research;Body Composition;carbohydrate metabolism;Cardiovascular Diseases;career;career development;Cause of Death;Child;Chronic Disease;Clinical;Clinical Research;Collaborations;combat;Communities;comorbidity;Complex;Coronary heart disease;Country;Data;Data Analyses;design;Diabetes Mellitus;Disease;Dyslipidemias;early-career faculty;Economic Burden;Educational Curriculum;Educational process of instructing;Educational workshop;Energy Metabolism;Equipment;Exercise Test;experience;Exposure to;Face;Faculty;family burden;Fostering;Grant;Health;health goals;healthy weight;Hypertension;Infrastructure;Institution;instructor;interest;International;Knowledge;Lead;Learning;Louisiana;Malignant Neoplasms;Medical;medical schools;meetings;Metabolic Diseases;Methods;Mission;Morbid Obesity;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Nutritional Study;Obesity;Persons;Physical activity;post-doctoral training;Postdoctoral Fellow;Prevalence;Procedures;professor;programs;Public Health;Reading;Research;research facility;Research Infrastructure;Research Methodology;Research Personnel;Research Support;Resources;Science;Scientist;Services;Site;social;Standardization;Strategic Planning;Stroke;success;Technology;theories;Training;trend;Underrepresented Populations;United States National Institutes of Health;volunteer;Vulnerable Populations;Work

PROJECT_TITLE: Clinical Methods for Nutrition and Obesity Research Course


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Orphan Drug;Pediatric;Pediatric - AIDS;Precision Medicine;Prevention;Rare Diseases;Social Determinants of Health;Tuberculosis

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: PROJECT NARRATIVE The proposal aims to address a key WHO End TB Strategy element, the improvement of diagnostic tools to enable the detection of the millions of missing cases, and has included cohorts from key areas of the world that are heavily affected by TB, as well as special target groups, like a wide age spectrum and people living with the important comorbidities, HIV infection and type 2 diabetes mellitus. A pipeline of novel tests that are suitable for different levels of health care and that target several key phases of host-pathogen interaction will be evaluated and include sputum-free triage and diagnostic tests, improved culture assays, predictive biomarker tests and a bacterial load marker test. The program promises to pave the way for cost-effective, novel and much improved diagnostic strategies for TB.

PI_NAMEs: BELISLE, JOHN T;SUTHERLAND, JAYNE ;WALZL, GERHARD  (contact)

PROGRAM_OFFICER_NAME: JONES, FATIMA D

PROJECT_TERMS: Address;Adult;Affect;Africa;Age;Area;Asia;Biological;Biological Assay;biosignature;Blood;Caring;Cessation of life;Child;Clinical;Clinical Research;clinical research site;co-infection;cohort;Communities;comorbidity;Complement;Complex;cost effective;Country;Detection;Diagnosis;Diagnostic;diagnostic strategy;Diagnostic tests;diagnostic tool;Diagnostics Research;Disease;disorder prevention;drug-sensitive;Early Diagnosis;Elements;Europe;Evaluation;experience;falls;Fingers;follow-up;Future;Gambia;Geographic Locations;Goals;head-to-head comparison;Health care facility;health care settings;Health Status;Healthcare;Healthcare Systems;high risk;HIV;HIV Infections;Household;implementation barriers;improved;Incidence;Infection;Infrastructure;International;Laboratories;laboratory facility;latent infection;lipoarabinomannan;Liquid substance;Measures;Medical;meetings;Messenger RNA;Methods;Molecular;Monitor;mortality;multidisciplinary;new technology;Non-Insulin-Dependent Diabetes Mellitus;novel;novel diagnostics;novel strategies;Outcome;pathogen;patient subsets;Patients;Performance;performance tests;Persons;Peru;Phase;point of care;predictive marker;predictive test;prevent;Preventive therapy;Primary Health Care;programs;progression risk;Prophylactic treatment;Proteins;Quantitative Reverse Transcriptase PCR;Reagent;Recurrence;Relapse;Resource-limited setting;Resources;Risk;Rural;Sampling;Scientist;Shapes;Side;socioeconomics;South Africa;South America;Southeastern Asia;Sputum;standard of care;Symptoms;targeted treatment;Testing;Time;Transcript;transmission blocking;treatment duration;Treatment Efficacy;Treatment outcome;Treatment Protocols;treatment response;treatment strategy;treatment stratification;Triage;Tuberculosis;tuberculosis treatment;urban area;urinary;Vietnam;Work

PROJECT_TITLE: Evaluation of new diagnostics for incident, active and recurrent TB (ENDx-Tb)


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Urologic Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Death from chemoresistant germ cell tumors (GCTs) account for the greatest number of life years lost of any non-childhood malignancy, and the origins and evolution to chemoresistance in this disease are incompletely characterized. We have developed data identifying reciprocal loss of heterozygosity (RLOH) as a disease- defining genomic defect in GCTs, presence of apoptotic priming underlying the more typical chemosensitivity, and accumulation of RLOH as GCTs evolve towards chemoresistance. Through the use of several novel molecular techniques applied directly to patient specimens, this proposal will enable this program to develop a more complete understanding of the factors driving oncogenesis and evolution to chemoresistance in this rare cancer, with the plan to translate targets revealed through this study to therapeutic development in this area of unmet medical need.

PI_NAMEs: VAN ALLEN, ELIEZER M (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Acceleration;Activities of Daily Living;Address;Affect;Algorithms;Alleles;Apoptosis;Apoptotic;Area;arm;Automobile Driving;Award;Biological Assay;Biology;Cancer Biology;Cancer Center;cancer genetics;cancer type;Cessation of life;Chemoresistance;chemotherapy;Chromosomes;Clinical;Clinical assessments;clinically actionable;Computational algorithm;Computational Biology;Dana-Farber Cancer Institute;Data;Defect;Development;Diagnosis;Disease;disease model;disorder risk;Dissection;DNA;DNA copy number;Early identification;Epigenetic Process;epigenetic silencing;epigenome;Event;Evolution;Exhibits;experimental study;Foundations;Genes;Genetic;Genetic Processes;Genetic Transcription;Genome;genome analysis;Genomics;Germ cell tumor;Germ Lines;Goals;high risk;Human;Individual;Infrastructure;innovation;Institution;Interdisciplinary Study;International;Investigation;Life Expectancy;Loss of Heterozygosity;Malignant Neoplasms;Mediastinum;Medical;Meiosis;Meiotic Recombination;Mitochondria;Modeling;Molecular;Molecular Analysis;mortality;Mutation;new therapeutic target;novel;Oncogenic;Oncology;Outcome;Ovary;patient oriented;patient stratification;Patients;Pattern;Persons;Phenotype;Platinum;pluripotency;Pre-Clinical Model;Predisposition;Procedures;prognostic;programs;rare cancer;Recurrence;Refractory Disease;relapse prediction;Research;Resistance;Resources;Sampling;Sentinel;Somatic Mutation;Specimen;Stratification;Study models;Techniques;Testicular Germ Cell Tumor;Testis;Therapeutic;therapeutic development;therapy resistant;transcriptomics;Translating;Translations;treatment strategy;tumor;tumor initiation;tumor progression;tumorigenesis;Urogenital Cancer;Work;years of life lost;young man

PROJECT_TITLE: Molecular origins and evolution to chemoresistance in germ cell tumors


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: STONY BROOK

ORG_DEPT: BIOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative IMSD at Stony Brook University: Maximizing Excellence in Research for Graduate Education This proposal aims to create a diverse group of highly motivated, exceptionally trained interdisciplinary scholars prepared to pursue research careers in the biomedical sciences. The training program focuses on efforts that build a strong, shared scientific identity amongst underrepresented biomedical science scholars across multiple degree programs, building their confidence and motivation to pursue research careers. These trainees will make novel contributions to the body of scientific knowledge that will lead to discoveries to improve our nation’s health.

PI_NAMEs: GERGEN, JOHN PETER (contact)


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Liver Disease;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Transplantation

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because there is an unmet need to develop new treatment approaches for patients with hereditary tyrosinemia type I (HT1) and other metabolic liver diseases which are a leading indication for liver transplants and cause significant morbidity and mortality. In this project, we seek to use gene editing, including its prenatal application, to treat HT1 as a model for other genetic metabolic liver diseases. Thus, the proposed research is relevant to the part of the NIH’s mission that seeks to develop fundamental knowledge to enhance health, lengthen life and reduce illness and disability.

PI_NAMEs: PERANTEAU, WILLIAM H. (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Adenine;Adult;Albumins;base;base editing;base editor;Birth;Cause of Death;Cell Line;Cells;Childhood;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Cytosine;Data;Development;Dioxygenases;disability;Disease;disease-causing mutation;DNA Double Strand Break;DNA Repair;endonuclease;Enzymes;fetal;Fetal Development;Fetal Liver;fetal stem cell;Fetal Weight;Fetus;Fumarylacetoacetase;gallium arsenide;gene editing technology;Gene Mutation;Gene Silencing;gene-editing approach;Genes;Genetic Diseases;Genome;Goals;Growth;Guanine;Guide RNA;Health;Hepatocyte;Human;Human Cell Line;Human Engineering;humanized mouse;Hydrolase;Immune;Immune Tolerance;Immunologics;improved outcome;in utero;In Vitro;in vivo;in vivo Model;Inbred BALB C Mice;innovation;insertion/deletion mutation;knockout gene;Knowledge;Life;lipid nanoparticle;Liver;liver cell proliferation;Liver diseases;Liver Failure;liver transplantation;Mediating;Metabolic;Mission;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;mutation correction;Nonhomologous DNA End Joining;Nonsense Mutation;novel;novel therapeutic intervention;Onset of illness;Organ;Other Genetics;Pathology;Pathway interactions;patient subsets;Patients;perinatal period;Pharmaceutical Preparations;Phenotype;postnatal;prenatal;Primary carcinoma of the liver cells;Proliferating;Property;Public Health;Publishing;repaired;Research;Resistance;Risk;RNA Splicing;Safety;safety and feasibility;Site;stem cells;success;Testing;therapeutic genome editing;Thymine;Transplantation;Tyrosine;Tyrosinemias;United States National Institutes of Health;Viral;Work

PROJECT_TITLE: In utero gene editing to cure a metabolic liver disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(02)M]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cervical Cancer;Clinical Research;Genetics;Human Genome;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Epigenetic DNA methylation patterns can serve as biomarkers for the detection of high-grade precancerous cervical lesions; however, few studies have investigated the utility of methylation markers as predictors of progression from low-grade to high-grade cervical intraepithelial neoplasia (CIN-1 to CIN-2/3). This study will utilize a unique combination of longitudinal outcomes and methylation array data in a prospective clinical cohort of women to assess relationships between early-stage DNA methylation, high-risk HPV infection, and the progression or persistence of CIN-1. Study findings will help identify novel methylation markers of cervical disease progression, improve the clinical management of low-grade cervical precancer, and contribute to our knowledge of HPV-related carcinogenesis.

PI_NAMEs: BUKOWSKI, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Address;Behavioral;Biological Markers;Biological Process;biomarker identification;cancer care;Cancer Control;cancer epidemiology;carcinogenesis;carcinogenicity;career;Cell Cycle;Cells;Cervical;cervical carcinogenesis;Cervical Intraepithelial Neoplasia;Cervical spinal cord injury;Cessation of life;Clinical;Clinical Data;Clinical Management;Clinical Research;clinically significant;Cluster Analysis;Cohort Studies;Complex;Cross-Sectional Studies;Cytosine;Data;Data Set;Detection;Development;Disease Outcome;Disease Progression;DNA Methylation;DNA Sequence Alteration;Doctor of Philosophy;Early treatment;Enrollment;Epidemiologic Methods;Epidemiology;Epigenetic Process;Exhibits;experience;Fellowship;follow-up;Future;Gene Expression;Genes;genetic epidemiology;Genome;global health;Goals;Guanine;Guidelines;Gynecologic Oncology;Health Priorities;high risk;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papillomavirus;Hypermethylation;improved;Learning;Lesion;London;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Mentors;Methods;Methylation;methylation biomarker;methylation pattern;Morbidity - disease rate;mortality;North Carolina;novel;Oncogenes;Outcome;Pathway Analysis;Physicians;potential biomarker;premalignant;Premature Birth;progression risk;Proliferating;prospective;public health priorities;Research;Risk;Risk Factors;Sampling;Scientist;screening;Site;skills;Specimen;statistics;Testing;The Cancer Genome Atlas;Time;Training;Universities;Viral Proteins;Woman;Women's cohort;Women's Health

PROJECT_TITLE: The effect of epigenetic DNA methylation on the progression of HPV-associated precancerous cervical lesions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-G(20)]