ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Pediatric

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE - Duke University By joining the newly organized and expanded Collaborative Pediatric Critical Care Research Network, Duke  Children’s and our ancillary site at the Medical University of South Carolina will enhance the scientific breadth  and reach of the network. Our sites are the leading academic centers in North and South Carolina, and will  ensure that critically ill children in both states have access to the cutting edge clinical trials and research  studies conducted by the network. Building on our experiences and expertise, we will provide deep scientific  expertise and training and mentoring opportunities to enrich the network with a focus on the areas of clinical  pharmacology, real-world evidence generation, and regulatory science.

PI_NAMEs: HORNIK, CHRISTOPH  (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Admission activity;Analgesics;Area;Beds;Biometry;Board Certification;Cardiology;career;career development;Child;Childhood;Clinical;Clinical Pharmacology;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;Collaborations;Comprehensive Health Care;Contracts;Critical Care;Critical Illness;Critically ill children;Data;Data Coordinating Center;Dedications;Development;Development Plans;Doctor of Philosophy;Drug Labeling;early-career faculty;Electronic Health Record;Enrollment;Ensure;expectation;experience;Extramural Activities;Faculty;Funding;Generations;Goals;Good Clinical Practice;Government;immunoregulation;improved outcome;Individual;Infant;innovation;Intensive Care;Intervention;Joints;Leadership;Life;Medical;medical schools;Medicine;meetings;member;Mentors;Mentorship;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;National Center for Advancing Translational Sciences;National Institute of Child Health and Human Development;Network Infrastructure;North Carolina;Nutritional Study;Participant;participant enrollment;Pediatric Acute Lung Injury;pediatric department;Pediatric Hospitals;Performance;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacologic Substance;pharmacometrics;Principal Investigator;Procedures;programs;Protocols documentation;Public Health;Publications;Recording of previous events;Research;Research Infrastructure;Research Institute;Research Personnel;research study;Research Training;Resources;Science;Scientist;sedative;Sepsis;Services;Site;South Carolina;success;Talents;Training;United States Food and Drug Administration;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Collaborative Pediatric Critical Care Research Network - Clinical Site


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: FULLERTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CALIFORNIA STATE UNIVERSITY FULLERTON

ORG_STATE: CA

PHR: CSUF/UCI-CFCCC Cancer Health Equity Research Partnership (CHERP)  Cancer Research Education Program (CREP): Narrative The Cancer-Related Education Program (CREP) will contribute to the enhancement of cancer health equity in Southern California. CREP will promote an increase in the diversity of the cancer research workforce by training undergraduate and master’s graduate students in cancer health disparities-related research efforts, especially those from underrepresented groups. CREP will provide cancer and cancer health disparities education to undergraduate and master’s students. CREP will also include several outreach activities at CSUF and UCI to disseminate information about the program and the importance of cancer research and cancer disparities. .

PI_NAMEs: TOLMASKY, MARCELO E (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;anti-cancer research;base;Biological;California;Cancer Burden;Cancer Center;cancer health disparity;Cancer health equity;career;career preparation;Communication;Communities;community building;Data;Degree program;Diagnosis;Education;education pathway;education research;Environment;ethnic diversity;Evaluation;experience;Face;Faculty;faculty mentor;Future;Goals;graduate student;Health Disparities Research;health disparity populations;health equality;Health equity research;Incidence;Institution;Instruction;Laboratories;Learning;Length;Malignant Neoplasms;Monitor;Morbidity - disease rate;mortality;novel;nutrition;operation;outreach;peer;Population;Population Heterogeneity;Prevalence;programs;Quality of life;recruit;Research;Research Personnel;Research Training;responsible research conduct;Scholars Program;Science;Scientist;Series;Sister;skills;Socioeconomic Factors;socioeconomics;Stress;Student Persistence;Students;success;summer research;survivorship;symposium;Talents;tool;Training;Travel;undergraduate student;underrepresented minority student;Underrepresented Populations;Underrepresented Students;Vertebral column;Work

PROJECT_TITLE: CHERP Cancer Research Education Program


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Immunization;Immunotherapy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: The DiPersio Unit strives to optimize immunotherapy, including allogeneic hematopoietic stem cell transplantation (alloHSCT), for treating hematological malignancies. Dr. DiPersio’s research program over the next several years will use our strengths in preclinical modeling, cancer genomics and the design and execution of early phase clinical trials to (1) develop novel methods for hematopoietic stem cell mobilization and treatment of graft-versus-host disease; (2) define the genetic and epigenetic changes that contribute to AML relapse after alloHSCT; and (3) perform clinical trials testing bispecific antibody or chimeric antigen receptor T cell (CART) therapies to treat hematological malignancies before or after HSCT. I serve as a laboratory-based scientist to accomplish the goals of Dr. DiPersio’s cancer research program.

PI_NAMEs: RETTIG, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Allogenic;AMD3100;Autoimmune Diseases;Back;bench to bedside;Bispecific Antibodies;Bone Marrow;Bone Regeneration;cancer genomics;Cancer Research Project;CAR T cell therapy;career;CD3 Antigens;chemotherapy;Clinical Trials;Correlative Study;curative treatments;CXCR4 gene;design;Disease;Down-Regulation;early phase clinical trial;efficacy evaluation;efficacy testing;Epigenetic Process;Exhibits;first-in-human;Goals;graft vs host disease;Hematologic Neoplasms;Hematopoiesis;Hematopoietic Stem Cell Mobilization;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemoglobinopathies;Hereditary Disease;Homing;Human;IL3RA gene;IL7 gene;immunogenic;Immunologics;Immunotherapy;Infusion procedures;inhibitor;Integrin alpha4beta1;Integrins;JAK1 gene;JAK2 gene;Laboratories;man;Manuscripts;Mediating;Metabolic Diseases;Methods;MHC Class II Genes;Minor Histocompatibility Antigens;Mus;Mutation;Non-Malignant;nonhuman primate;novel;Patients;Peer Review;Polyethylene Glycols;Post Graduate Year;Postdoctoral Fellow;Pre-Clinical Model;preclinical study;programs;Recurrent disease;Relapse;Research;Scientist;small molecule inhibitor;success;Testing;Time;Training;Transplantation;tumor

PROJECT_TITLE: BM NICHE DISRUPTION AND IMMUNOTHERAPY IN HEMATOLOGICAL MALIGNANCIES


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases;Regenerative Medicine

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Viral pneumonia progressing to acute respiratory distress syndrome (ARDS) represents a significant public health concern given the constant threat of emerging, highly pathogenic respiratory viruses (SARS-CoV-2 / COVID-19) as well as increased vulnerability of elderly and immunocompromised individuals with even mild seasonal influenza strains. The purpose of this proposal is to identify the molecular mechanisms required to achieve effective regeneration of the capillary endothelium, and how signals from the regenerating endothelial cells themselves promote alveolar epithelial repair. Ultimately these studies will facilitate more targeted therapies / approaches to lung vascular repair to reduce mortality and promote recovery from ARDS.

PI_NAMEs: VAUGHAN, ANDREW  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: 2019-nCoV;Acute Respiratory Distress Syndrome;Address;Alveolar;alveolar epithelium;angiogenesis;Animals;antagonist;autocrine;Automobile Driving;Binding;Biological Assay;Blood capillaries;Blood Vessels;capillary bed;Capillary Endothelial Cell;Cell Death;Cell Proliferation;Cells;ChIP-seq;COVID-19;Data;design;Elderly;Endoglin;Endothelial Cells;endothelial regeneration;endothelial repair;Endothelium;Epithelial Cell Proliferation;Epithelial Cells;epithelial repair;Epithelium;epithelium regeneration;Exposure to;Fibrosis;Gases;Genes;Glycoproteins;Hypoxemia;Immunocompromised Host;improved;In Vitro;in vivo;Individual;inducible Cre;Infection;Influenza;Influenza A Virus, H1N1 Subtype;influenza virus strain;Injury;Lung;lung injury;lung repair;MADH2 gene;Mediating;Modeling;Molecular;mortality;Mus;Natural regeneration;novel;Organoids;overexpression;pandemic disease;pathogen;Pathogenicity;Pathologic;Pathway interactions;Patients;Persons;Physiological;prevent;progenitor;Proliferating;protective pathway;Proteins;Public Health;Pulmonary Edema;pulmonary function;receptor;Recovery;regeneration function;regeneration potential;Regenerative response;repair function;repaired;Reporting;respiratory virus;Role;seasonal influenza;Signal Pathway;Signal Transduction;single-cell RNA sequencing;targeted treatment;Testing;TGFBR2 gene;Therapeutic;tissue repair;Toxin;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Up-Regulation;Vascular Endothelium;Vascular regeneration;Viral Pneumonia;Work

PROJECT_TITLE: Coordinated regeneration of lung epithelial and endothelial compartments

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Mental Health;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Displaced populations experience an elevated burden of mental disorder alongside very limited access to mental health services. As forced displacement continues to rise to unprecedented levels (over 84 million people in 2021), innovative strategies to improve reach and retention in mental health services for hard-to- reach displaced populations, such as migrants in transit, are needed to reduce the global burden of mental disorders. By leveraging participatory methods in implementation science, human-centered design, and systems science, this research aims to discover novel approaches to improving access to care for migrants in transit, which will facilitate innovations that may be translated to improving mental health service delivery in other settings and hard-to-reach populations.

PI_NAMEs: GREENE, MARTHA CLAIRE (contact)

PROGRAM_OFFICER_NAME: CAMPBELL-ROSEN, HOLLY RENEE

PROJECT_TERMS: Acceleration;Back;career;career development;Caring;Cities;Collaborations;Colombia;Colombian;Communities;comparative;Complex;Country;COVID-19 pandemic;Data;Dedications;design;Destinations;Development Plans;displaced person;Economics;Educational workshop;effectiveness testing;effectiveness/implementation trial;Emergency Situation;Equity;evidence base;experience;Focus Groups;Goals;Grant;health care delivery;health disparity;Health Personnel;Health Services Accessibility;Health system;Human;human centered design;Hybrids;implementation design;implementation science;implementation strategy;Improve Access;improved;improved outcome;Individual;innovation;Intention;Interruption;Intervention;Latin America;Lead;Legal;marginalization;Measures;Mental disorders;Mental Health;Mental Health Services;Mentored Research Scientist Development Award;Mentorship;Methods;Migrant;migration;model building;National Institute of Mental Health;Nongovernmental Organizations;novel strategies;Peripheral;Persons;Policy Maker;Politics;Population;post implementation;Prevalence;programs;psychologic;Research;Resources;Route;Science;Series;Service delivery model;skill acquisition;social determinants;Specific qualifier value;System;Testing;Time;Time Series Analysis;Training;Translating;trauma exposure;trend;Universities;usability;Venezuela;Venezuelan;Visualization

PROJECT_TITLE: Optimizing implementation of evidence-based mental health interventions to promote reach and retention among migrants in transit in humanitarian emergencies

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Genetics;Lung;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Release of histones by affected organs and tissues during trauma or severe inflammation leads to profound microvascular endothelial damage and organ failure, but cellular mechanisms of endothelial dysfunction induced by circulating histones remain poorly understood. This project investigates new receptors by which extracellular histones target lung microvascular endothelium and cause sustained endothelial dysfunction. Identification of new pathways of microvascular endothelial cell death caused by extracellular histones may lead to development of new inhibitory compounds targeting histone-activated cell receptors.

PI_NAMEs: BIRUKOVA, ANNA  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Affect;Agonist;Animal Genetics;Animal Model;Area;Bacteria;Binding;Biochemical;Blood Vessels;Brain Edema;Cause of Death;Cell Death;Cell Death Induction;cell injury;Cell Nucleus;Cells;Cessation of life;Circulation;Complex;Data;Development;DNA-Binding Proteins;Dose;Endothelial Cells;endothelial dysfunction;Endothelium;extracellular;Failure;Fostering;Functional disorder;Genetic Models;Health;Histones;imaging approach;Immune;improved;Infection;Inflammation;Inflammatory;injured;Injury;insight;Investigation;Knowledge;Lipids;Lung;lung injury;Mediating;Membrane Lipids;Membrane Microdomains;Microcirculation;Modeling;Molecular;Molecular Target;mortality;Multiple Organ Failure;Necrosis;NF-kappa B;novel;novel therapeutic intervention;Nuclear;Operative Surgical Procedures;Organ;Organ failure;Particulate Matter;pathogenic bacteria;Pathologic;Pathway interactions;Patients;Pattern;Peptides;Permeability;Pilot Projects;Play;Prognostic Factor;Publishing;Pulmonary Edema;receptor;Receptor Cell;recruit;Regulation;respiratory;response;scavenger receptor;Sepsis;Severities;Signal Transduction;Staphylococcus aureus;Stimulus;Surface;Syndrome;Testing;tissue injury;Tissues;TNFRSF10B gene;Toxin;trafficking;translational study;Trauma;Traumatic injury;Vascular Diseases;Vascular Endothelial Cell;Vascular Endothelium;vascular inflammation;Vascular Permeabilities

PROJECT_TITLE: Mechanisms of microvascular endothelial cell injury caused by extracellular histones

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Atherosclerosis and its cardiovascular consequences are the number one killer of both men and women in the United States, placing a considerable burden on US health care delivery and its costs. The mechanisms leading to accumulation of lipids in arteries are unclear. This project aims to open an entirely new field of inquiry by investigating the mechanisms of monocyte lipid uptake and will identify previously unknown therapeutic targets to inhibit atherosclerosis promoting lipid entry into the arterial wall.

PI_NAMEs: AHN, WONMO  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Academic Training;Adhesions;Affinity;Arteries;Atherosclerosis;Attenuated;Biology;Blood Vessels;Cardiovascular system;Cause of Death;CD36 gene;Chemical Stimulation;Chemicals;Consensus;cost;cytokine;Data;Development;Endothelium;FDA approved;Foam Cells;Funding;Genetic;Goals;Health;health care delivery;Human;hypercholesterolemia;improved;In Vitro;in vivo;Inflammatory;inflammatory marker;inhibitor;insight;Ischemic Stroke;Knockout Mice;Lipids;Liquid substance;Low-Density Lipoproteins;Macrophage;Mediating;medical schools;Membrane;men;Mentorship;Methodology;migration;monocyte;Mus;Myeloid Cells;Myocardial Infarction;new therapeutic target;NHE1;novel;Pathogenesis;Pathway interactions;Patients;Peripheral arterial disease;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Physiological;Plasma;Play;post-doctoral training;Pre-Clinical Model;pre-doctoral;Process;Publishing;receptor;receptor mediated endocytosis;Recording of previous events;Research;Role;scavenger receptor;Secure;skills;Stroke;Technical Expertise;Testing;Tetradecanoylphorbol Acetate;therapeutic target;therapeutically effective;Time;Training;United States;Universities;uptake;Woman

PROJECT_TITLE: Mechanisms of foamy monocyte formation in atherosclerosis


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Charcot-Marie-Tooth Disease;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Peripheral Neuropathy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Charcot-Marie-Tooth Disease Type 4B3 is a devastating complex axonal neuropathy which onsets very early in life and features neurodevelopmental delay, central nervous system involvement and musculoskeletal defects. The gene responsible for CMT4B3 is Sbf1, which encodes Myotubularin- Related Protein 5, a hypothesized regulator of endo-lysosomal trafficking and autophagy in neurons, two processes that are critical in early development. This project will therefore examine the specific molecular mechanisms of axon degeneration in Charcot-Marie-Tooth Disease Type 4B3 due to mutations in MTMR5 and will seek to identify robust cellular phenotypes that can be used for identification of therapeutic targets and genetic therapy validation.

PI_NAMEs: JACOBS, ELIZABETH HALEY (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: 3-Dimensional;Affect;Alleles;analysis pipeline;Autophagocytosis;autosome;Axon;axonal degeneration;Axonal Neuropathy;Binding;Biochemical;Bioinformatics;Biological Markers;Central Nervous System;Charcot-Marie-Tooth Disease;Child;Childhood;Clinical;Co-Immunoprecipitations;Complex;Cranial Nerves;Cytoskeleton;Data;Data Set;Defect;Demyelinations;Development;Disease;drug development;drug discovery;drug repurposing;Drug usage;early childhood;Endosomes;Exhibits;Expression Profiling;Face;Fellowship;Fluorescent Dyes;Functional disorder;Future;gain of function;Gene Expression;Gene Expression Profile;Gene Expression Profiling;gene replacement;gene therapy;Genes;Goals;hereditary neuropathy;high throughput screening;Homeostasis;Human;Image;Imaging Techniques;Immunofluorescence Immunologic;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;infancy;Inherited;inhibitor;Inositol;insight;Intellectual functioning disability;Intracellular Membranes;Knowledge;Lead;Life;Link;loss of function;Mass Spectrum Analysis;Mediator;Mission;Modality;Modeling;Molecular;Molecular Profiling;Motor Neurons;mouse model;Mus;Musculoskeletal;mutant;Mutation;myelination;myotubularin;National Institute of Child Health and Human Development;Nerve Degeneration;nervous system development;neurodevelopment;Neurodevelopmental Disorder;Neurologist;Neuromuscular Diseases;neuronal cell body;Neurons;Neuropathy;Other Genetics;Pathogenesis;Pathologic;Pathway interactions;Patients;Pattern;Peptides;Peripheral Nerves;Peripheral Nervous System;Peripheral Nervous System Diseases;Phenotype;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Phosphotransferases;Play;Polyneuropathy;Process;protein complex;protein protein interaction;Proteins;recruit;Reproducibility;Residual state;Rodent Model;Role;Schwann Cells;Scientist;sensor;Signaling Molecule;spheroids;Spinal;stem;Symptoms;System;targeted treatment;Therapeutic;therapeutic evaluation;therapeutic target;tool;Toxic effect;trafficking;Training;Validation;validation studies;Work

PROJECT_TITLE: Mechanisms of Neurodegeneration in CMT4B3: a Complex Pediatric Neurodevelopmental Disorder


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Pain;Infectious Diseases;Neurosciences;Pain Research;Urologic Diseases

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative  Urination is critical for waste removal, but also causes a huge pathological burden for many people who struggle with lower urinary tract problems. The lower urinary tract depends on mechanical signals from the urothelium and the nervous system to function properly, but the mechanisms by which mammals detect these mechanical cues, like bladder stretch, are not well defined. I seek to understand how mechanosensing functions in the urinary tract at the molecular, cellular and physiological level.

PI_NAMEs: MARSHALL, KARA L (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Adult;Affect;Afferent Neurons;Animals;Attenuated;Behavior;Behavioral;Biological Assay;Bladder;bladder pain;Breeding;Calcium;cell type;Complex;Cystitis;Detection;detector;Electromyography;Excision;Exposure to;fluid flow;Genes;Genetic Models;Health;Histology;Human;Hypersensitivity;Image;Impairment;In Vitro;in vivo;Ion Channel;Knock-out;Knockout Mice;Liquid substance;Lower urinary tract;Mammals;mechanical allodynia;mechanical force;mechanical signal;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Mediator;Medical;Micturition Reflex;Modeling;Molecular;Mus;Nervous System;neuronal excitability;Neurons;neurotransmission;Nociceptors;Pain;pain behavior;pain sensation;Pathologic;Pathology;Peripheral;Persons;Pharmacology;Physiological;Physiology;Piezo 1 ion channel;Piezo 2 ion channel;Preparation;pressure;Process;Reflex action;Reporting;Respondent;response;Role;sensor;Signal Transduction;Signaling Molecule;Smooth Muscle;Stimulus;Stretching;Striated Muscles;Surveys;System;Techniques;Testing;Urethra;Urethral sphincter;urinary;Urinary tract;Urination;Urodynamics;Urothelial Cell;Urothelium;wasting;Work

PROJECT_TITLE: Molecular mechanisms of mechanosensing in the urinary tract

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: Project Narrative  We will use MRI to measure brain blood flow and energy demand in infants with and without brain injury to determine whether anesthesia compromises their ability to meet their energy demand. We will identify changes in brain blood flow and energy demand that increase the risk of adverse cogitative outcomes in infants exposed to anesthesia. We will also compare two popular anesthetic agents to determine which one best protects infants against changes in blood flow and energy demand.

PI_NAMEs: BORZAGE, MATTHEW  (contact)

PROJECT_TERMS: 1 year old;8 year old;Acute;Address;Adult;adverse outcome;Aerobic;Affect;Age;Anesthesia procedures;Anesthetics;Animals;Apoptosis;axon injury;behavioral outcome;Blood flow;Brain;Brain Hypoxia;Brain Hypoxia-Ischemia;Brain Injuries;brain metabolism;Calcium;career;Cell Physiology;cerebral hemodynamics;cerebral oxygenation;Cerebrovascular Circulation;Cerebrum;Characteristics;Chemicals;Child;Childhood;Clinical;clinical practice;Cognitive;cognitive performance;cohort;Cohort Studies;Coupled;Coupling;Critical Care;cytotoxic;Dendrites;design;Diagnosis;Diagnostic;Disease;Enrollment;Equipoise;Exhibits;Exposure to;Future;Goals;hemodynamics;Hypoxia;Image;image processing;Impairment;improved;Individual Differences;Infant;Injury;Investigation;Ion Channel;Knowledge;Learning;Link;Liquid substance;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Medical;Metabolic;Metabolism;metabolomics;MRI Scans;National Heart, Lung, and Blood Institute;neonatal hypoxic-ischemic brain injury;neural;neurite growth;neurodevelopment;neuroimaging;Neurons;neurotoxicity;Neurotoxins;Outcome;Oxygen;Patients;pediatric patients;Pharmaceutical Preparations;Pilot Projects;potential biomarker;predictive marker;preference;prevent;Propofol;Provider;Randomized;Regulation;Reporting;Research;Research Design;Research Project Grants;response;Risk;Scanning;Sedation procedure;sedative;sevoflurane;skills;Techniques;Testing;Translational Research;Traumatic Brain Injury;treatment response

PROJECT_TITLE: Investigation of Cerebral Hemodynamics and Oxygenation Relationships Under Sedation in Children: ICHOR USC

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(JA)]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative To successfully navigate its environment, an animal must be able to perceive both the orientation of its body in space and how its body moves through space; this perception requires integrating vestibular, somatosensory, and visual input in a contextually relevant manner. The proposed research will investigate how the parieto-insular vestibular cortex (PIVC) of non-human primates performs this multisensory integration and facilitates higher- order vestibular functions such as the perception of self-motion. This research will vastly improve our basic understanding of vestibular cortical function; in turn, this research will provide clinically relevant insight to physicians treating human patients who are experiencing dysfunctions related to vestibular cortical injury.

PI_NAMEs: GOMEZ, ALEJANDRA  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Animals;Area;Auditory;Automobile Driving;Awareness;Behavior;Behavioral;Body part;Brain;Cells;Clinical;clinically relevant;Cognitive;cognitive function;cognitive process;Cutaneous;density;Environment;Equilibrium;Ethology;experience;experimental study;extracellular;Functional disorder;Gait;gaze;Goals;Head;Head Movements;Human;imaging study;Impairment;improved;Individual;Injury;insight;Insula of Reil;Learning;Lesion;Modality;Modeling;Motion;Motion Perception;Motor;Movement;multimodality;multisensory;Musculoskeletal Equilibrium;neural;neuromechanism;Neuronal Differentiation;Neurons;neurophysiology;nonhuman primate;Organism;Outcome;Parietal Lobe;Patients;Perception;Physicians;Play;Population;Posture;Primates;Process;Reporting;Research;response;Role;Scheme;Self Perception;Sensory;sensory input;sensory integration;Signal Transduction;Skeletal muscle structure of neck;somatosensory;Space Perception;Stimulus;Stream;System;Tactile;Testing;Thalamic Nuclei;Thalamic structure;Vertebrates;Vestibular function;Vestibular nucleus structure;vestibular system;Visual;way finding

PROJECT_TITLE: Multisensory integration and self-motion perception in primate vestibular cortex


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: BIOLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE The lateral septum (LS) is anatomically situated to control a wide range of motivated behaviors, many of which are dysregulated in psychiatric disorders. However, little is known about how this critical brain region functions in normal and disease states. This proposal seeks to characterize how various LS projection populations participate in reward-related behaviors so that in the future they may be targeted for novel therapeutic interventions.

PI_NAMEs: ISAAC, JENNIFER SAMANTHA (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Address;Anatomy;Anxiety;Behavior;Behavioral;behavioral outcome;Behavioral Paradigm;Biological Assay;Brain region;Calcium;Cues;Disease;disorder prevention;Dissection;Electric Stimulation;Event;Feeding behaviors;Future;Genetic;Head;hedonic;Heterogeneity;Hippocampus;Hypothalamic structure;Image;imaging study;insight;Label;Lateral;Lesion;Literature;Mediating;Mental disorders;Methods;Microscope;motivated behavior;Motivation;Mus;neural;neural circuit;neural correlate;Neurons;new therapeutic target;novel;novel therapeutic intervention;optogenetics;Pathway interactions;Phenotype;Population;Population Projection;Positioning Attribute;prevent;Property;reinforced behavior;Research;Research Personnel;Resolution;reward processing;Rewards;Role;Self Stimulation;sensor;Series;Structure of terminal stria nuclei of preoptic region;Target Populations;theories;tool;Training;Ventral Tegmental Area;Viral;Visit;With laterality;Work

PROJECT_TITLE: Examining the neural substrates of reward in the lateral septum


NIH_SPENDING_CATS: Bioengineering;Diabetes

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE Insulin is an essential and effective therapeutic for the treatment of diabetes. Nevertheless, there remain serious limitations with currently available therapeutic insulins, including relatively slow biological activity following subcutaneous injection, instability, and co-stimulation of biological pathways that promote tumor growth. This proposal seeks to gain mechanistic insights that will inform efforts to develop improved therapeutics that overcome these limitations.

PI_NAMEs: HILL, CHRISTOPHER P. (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Acute;Address;Allosteric Site;analog;Animals;antagonist;aptamer;Binding;Biochemical;Biological;blood glucose regulation;C-terminal;Cessation of life;Chronic;Clinical;Cold Chains;Compensation;Complex;Cone;Cryoelectron Microscopy;Curiosities;Data;design;Development;Diabetes Mellitus;Disulfides;DNA;Engineering;experience;experimental study;Fishes;Future;Glucose;Goals;Growth;Health;Hyperglycemia;Hypoglycemia;Immobilization;improved;insight;Insulin;insulin dimers;Insulin Infusion Systems;Insulin Receptor;Insulin Resistance;Insulin, Lispro, Human;interest;Lead;Length;Ligands;Long-Acting Insulin;Metabolic Control;Metabolic Pathway;Miniature Swine;Molecular;Molecular Conformation;Mus;Mutation;nanodisk;Negative Staining;next generation;novel;Outcome;Pathway interactions;Patients;Peptides;Persons;Phage Display;Physiological;preclinical study;prevent;Property;Proteins;Pump;Rattus;receptor;receptor binding;Receptor Signaling;reconstruction;Refrigeration;Reporting;Resistance;Resolution;response;Serum;Signal Pathway;Signal Transduction;Snail Venoms;Snails;Structure;Subcutaneous Injections;success;Testing;Therapeutic;therapeutically effective;Transmembrane Domain;tumor growth;Tumor Promotion;type I diabetic;Variant;Venoms;Visualization

PROJECT_TITLE: Structural Insights to Insulin Receptor Ligand Interactions

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


PHR: PROJECT NARRATIVE: Hemostasis and blood clot formation is thought to be driven primarily by coagulation factors, platelets, and fibrinogen and intracerebral hemorrhage (ICH) treatment paradigms focus on optimizing these components to minimize ongoing bleeding. However, outside of their known role of oxygen delivery, there is evidence that erythrocytes, otherwise known as red blood cells (RBCs), also play a role in hemostasis and blood clot formation. This project will explore the independent contribution of RBCs on both hemostasis and cerebral oxygenation after ICH in efforts to identify novel treatment targets to improve ICH outcome.

PI_NAMEs: ROH, DAVID  (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Activated Partial Thromboplastin Time measurement;Acute;Admission activity;Affect;Anemia;Animal Experimentation;Animals;Antifibrinolytic Agents;Back;bench to bedside;Binding;Blood coagulation;Blood Coagulation Disorders;Blood Coagulation Factor;Blood Platelets;Blood Tests;Cerebral hemisphere hemorrhage;Cerebral Hypoxia;cerebral oxygenation;Cerebrum;Cessation of life;Clinical;Clinical Trials;clinically relevant;Coagulation Process;Data;Death Rate;disability;Endothelium;Erythrocyte Transfusion;Erythrocytes;Event;Fibrinogen;Future;Hematoma;Hemorrhage;Hemostatic function;Hour;Human;human study;Impairment;improved;improved outcome;Injury;innovation;insight;interstitial;Knowledge;Literature;Measures;Mediating;Methodological Studies;Monitor;Morbidity - disease rate;mortality;mouse model;novel;Observational Study;Outcome;Oxygen;patient population;Patient-Focused Outcomes;Patients;Plasma;Platelet Count measurement;Platelet Transfusion;prevent;prospective;Prothrombin time assay;Radial;Research;Risk;Risk Factors;Role;Scalp structure;skills;Stroke;stroke patient;Subarachnoid Hemorrhage;TBI Patients;Testing;Thrombelastography;tissue oxygenation;Tissues;tool;Training;Transfusion;translational scientist;Traumatic Brain Injury;Venous;Whole Blood

PROJECT_TITLE: Erythrocyte contribution to coagulopathy and cerebral oxygenation after intracerebral hemorrhage

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Maternal substance use can have lasting consequences on child development; however, the vast majority of research in this area has focused exclusively on how prenatal substance use can impact child neurocognitive outcomes. The proposed study will be one of the first to examine how prenatal and continued household exposure to maternal substance use may affect child neurocognitive development in early adolescence, recognizing that maternal substance use does not happen in isolation and the role of other psychological risk factors will be addressed. Findings will be critical to informing our understanding of how prior and continued maternal substance use, alongside psychological risk factors, affect child neurocognitive development and will inform intervention and treatment programs for families in the context of maternal substance use.

PI_NAMEs: FUNARO, KATHRYN MARY WALL (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: 17 year old;Address;Adolescence;Adolescent;Adolescent and Young Adult;Affect;Age;aged;Alcohols;Amygdaloid structure;Anxiety;Area;Attention;Back;Behavior;Behavior assessment;behavior measurement;Behavioral;Brain;Child;Child Development;Child Rearing;Childhood;Clinical;Cognition;cognitive development;comorbidity;Cues;Data;Development;early adolescence;executive function;Exposure to;Family;Fetal Development;fetal substance exposure;Foundations;frontal lobe;Functional Magnetic Resonance Imaging;Future;Household;illicit drug use;Impairment;indexing;Infant;Infant Development;innovation;Intervention;intervention program;life span;Maternal Health;Measures;Mental Depression;Mothers;neural;Neurocognitive;Neuropsychology;Outcome;Parents;Performance;postnatal;Postpartum Period;Pregnancy;Pregnant Women;prenatal;prenatal exposure;psychologic;psychological symptom;Psychopathology;Reaction Time;Relapse;Research;Risk;Risk Factors;Role;Shapes;Signal Transduction;Sorting;substance use;Substance Use Disorder;Task Performances;Trauma;treatment program;United States;United States National Institutes of Health;Ventral Striatum;Woman;Work

PROJECT_TITLE: Investigating the role of substance use exposure and maternal psychological risk on child neural and behavioral assessments of executive functioning


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Chronic social stress can cause a range of behavioral and physiological consequences, but some individuals are resilient to these effects. Understanding how neural circuit activity differs among stress susceptible and stress resilient individuals can offer clues to the mechanisms underlying stress and elucidate how experience can persistently transform brain activity in general.

PI_NAMEs: BOXER, EMMA E (contact)

PROJECT_TERMS: Aggressive behavior;Amygdaloid structure;Animals;Behavior;Behavioral;behavioral outcome;Biological Assay;Brain;BRAIN initiative;Calcium;cell type;Chemosensitization;Chronic;Classification;Color;Complement;Complex;Cre driver;Data;Disinhibition;Electrophysiology (science);Equilibrium;experience;fighting;flexibility;Genetic;Genetic Markers;Goals;Hypothalamic structure;Image;in vivo;in vivo imaging;Individual;Individual Differences;insight;Instinct;Interneurons;Label;Maps;Mediating;Mental disorders;Methods;Nature;neural;neural circuit;neuromechanism;neuronal circuitry;Neurons;optogenetics;Outcome;Physiological;Population;Predisposition;prevent;Property;Publishing;Reaction;Research;Research Training;resilience;Role;Slice;social;Social Behavior;social defeat;social stress;Stress;stress resilience;Synapses;Synaptic plasticity;Testing;Time;Training;transcriptomics

PROJECT_TITLE: Mechanisms of experience-dependent plasticity in an innate social behavior circuit


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Community-academic partnerships are commonly formed to address environmental health concerns in environmental justice communities. Increasingly, these teams attempt to use low-cost air sensors to understand air pollution exposures, but the appropriate use of these devices requires specific training. The RISE Communities program will support successful community-academic partnerships through dedicated training focused on team-building and the technical skills to successfully conduct community-engaged research (CEnR) using low-cost air sensors.

PI_NAMEs: KNAPKE, JACQUELINE ;RYAN, PATRICK H (contact)

PROGRAM_OFFICER_NAME: GARTON, AMANDA E

PROJECT_TERMS: Active Learning;Address;Air;air monitoring;Air Pollutants;Air Pollution;Awareness;Calibration;Cardiopulmonary;Cardiovascular Diseases;Collaborations;Color;Communities;community academic partnership;Community Developments;community engaged research;Community of Practice;community partnership;cost;Data;Data Analyses;Data Collection;data exchange;data management;data to knowledge;data visualization;Dedications;design;Development;Devices;Disparity;education research;Educational workshop;Environment;Environmental Health;environmental justice;Equity;Evaluation;evidence base;expectation;experience;Face;Faculty;Fostering;Health;Home;human disease;improved;Industrialization;Information Dissemination;innovation;Justice;Knowledge;Lead;Learning;learning community;Maintenance;Marketing;Measures;member;Modeling;Monitor;Morbidity - disease rate;mortality;Neighborhoods;Outcome;Participant;Particulate Matter;Persons;Policies;Pollution;Problem Solving;Process;programs;Psyche structure;Public Health;recruit;Research;Research Design;Research Methodology;Research Personnel;Resource Sharing;Respiratory Disease;Risk;Role;sensor;sensor technology;social learning;Source;source localization;success;Surveys;Team Process;Technical Expertise;Technology;Time;Training;Translating;Trust;United States;virtual;webinar

PROJECT_TITLE: Research Innovations using Sensor Technology in Environmental Justice Communities (RISE Communities)


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: NUTRITION

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: NARRATIVE Despite notable advances in our understanding of hazardous compounds over the past century, there are many compounds or hazards for which there is little or no regulatory guidance. As industrial hygienists and those in related fields must often make immediate decisions regarding how to assess and manage these hazards on a daily basis, it is imperative that they have access to the most current information available regarding management of these hazards. In this project we will provide this information for prospective graduate students, graduate students, and career professionals via development of online courses, online laboratories, and in- person research training.

PI_NAMEs: WELLS, ELLEN M (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: Address;Aerosols;Air;Algal Blooms;Biological Markers;career;Charge;Chemicals;curriculum development;Data Analyses;Data Collection;design;Development;Distance Education;E-learning;Education;Educational Curriculum;Elements;Emerging Technologies;experience;Exposure to;Faculty;Florida;Fostering;Future;Goals;graduate student;Guidelines;hazard;Hazard Management;Hazardous Chemicals;Hazardous Substances;Health;improved;Individual;Industrial Health;Industrialization;innovation;Institution;Instruction;interdisciplinary collaboration;Internet;Intuition;Knowledge;Laboratories;laboratory experiment;Learning;Learning Module;Measurement;method development;Methods;Monitor;nanoparticle;Occupational Health;online course;online version;ototoxicity;Participant;pedagogy;Persons;Population Heterogeneity;prevent;programs;prospective;Public Health;Quality of life;Recording of previous events;Recruitment Activity;Regulation;Research;Research Project Grants;Research Training;Resources;Risk;Risk Assessment;Running;Safety;Safety Management;Sampling;Series;skill acquisition;Specialist;summer research;System;Technology;Time;Training;Training Activity;Training and Education;Uncertainty;Underserved Population;United States;Universities;virtual laboratory;virtual reality;web site;Workplace

PROJECT_TITLE: Distance Education and Training on Emerging Contaminants and Technologies (DETECT)


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Pediatric;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative Consequences from heavy alcohol use build through mid-adulthood yet the factors that predict chronic alcohol problems in this age range are under-studied and therefore not well understood. The proposed research will leverage data spanning development from adolescence through mid-adulthood to test hypotheses about how risk for negative alcohol outcomes may change over time and differentially for adults with and without childhood ADHD -- a frequently diagnosed psychiatric illness that carries risk for alcohol problems and alcohol use disorder in adulthood. Identification of the dynamic and transactional processes that may underlie risk for alcohol problems for adults without and without a history of ADHD will aide in the development of personalized treatment targets to ultimately decrease alcohol use problems in this vulnerable population.

PI_NAMEs: MOLINA, BROOKE S.G. (contact);PEDERSEN, SARAH L

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: Address;Adolescence;Adolescent and Young Adult;Adult;Age;Aging;Alcohol abuse;Alcohol consumption;alcohol misuse;alcohol risk;alcohol use disorder;Alcoholism;Alcohols;Attention deficit hyperactivity disorder;Behavioral;Buffers;Child;Childhood;Chronic;cohort;coping;cost;Coupled;Data;Depressed mood;design;Development;Developmental Process;Diagnosis;Dimensions;Disease;drinking;Ecological momentary assessment;emerging adult;Employment;Environmental Risk Factor;Etiology;Family;Goals;Growth;Health;Heavy Drinking;high risk drinking;high risk population;improved;Impulsivity;indexing;Individual;informant;late life;Life;life span;Literature;longitudinal design;Longitudinal Studies;Measurement;Measures;Mental disorders;Mental Health;Methods;middle age;Moods;National Institute on Alcohol Abuse and Alcoholism;Nature;negative mood;Negative Reinforcements;novel;Outcome;Pathway interactions;personalized medicine;Persons;Phase;Predictive Factor;Process;prospective;Prospective Studies;Protocols documentation;Psychiatric Diagnosis;Recording of previous events;Recovery;Reporting;Research;Risk;Risk Factors;Sampling;Sampling Studies;Self Assessment;Severities;Sleep;Sleep disturbances;Social Environment;Social support;Stress;stressor;Stretching;Symptoms;Testing;Time;Transact;Vulnerable Populations;Work;young adult

PROJECT_TITLE: The Pittsburgh ADHD Longitudinal Study: Predicting alcohol misuse, problems and disorder in mid-adulthood

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The choroid plexuses (ChP) provide a critical blood-CSF barrier whose breakdown is implicated in several neurological and psychiatric disorders. The goal of this study is to investigate the molecular mechanisms by which GPCR-cAMP signaling regulate permeability of the blood-CSF barrier. Successful completion of this project will provide a roadmap for the molecular mechanisms regulating ChP barrier integrity, targets which can be exploited to improve therapeutic interventions.

PI_NAMEs: FIGUEROA VELEZ, DARIO XAVIER (contact)

PROJECT_TERMS: Adult;Agonist;Apical;apical membrane;awake;bench to bedside;Biochemical;Biological Assay;Biology;Blood;Blood - brain barrier anatomy;blood cerebrospinal fluid barrier;Blood Circulation;Blood-Borne Pathogens;Boston;Brain;Brain Diseases;Brain Hypoxia-Ischemia;brain tissue;Calcium;career;cell type;Cells;Central Nervous System;Cerebral Ventricles;Cerebrospinal Fluid;Choroid Plexus Epithelium;Collaborations;Coupled;Cyclic AMP;Cyclic AMP Receptors;Cyclic AMP-Dependent Protein Kinases;Data;Development;Dextrans;Disease;Electron Microscopy;Endothelial Cells;Endothelium;Environment;Epilepsy;Epithelial Cells;experimental study;Exposure to;Fellowship;Fluorescent Dyes;G-Protein-Coupled Receptors;Glutamates;Goals;Health;Image;imaging modality;Imaging Techniques;Imaging technology;improved;In Vitro;in vivo;in vivo imaging;in vivo optical imaging;in vivo two-photon imaging;Individual;Intravenous;intravenous injection;Investigation;Laboratories;lateral ventricle;Ligands;Link;Maps;Measures;Mediating;Mental Depression;Mental disorders;Mentors;metabotropic glutamate receptor 8;Methods;Molecular;Molecular Weight;Mus;Nervous System Disorder;Neuroglia;Neurologic;neuroprotection;Neurotransmitters;novel strategies;Pediatric Hospitals;Peripheral;Peripheral Nervous System;Permeability;Play;Population;Predisposition;Preparation;Process;Production;Property;Protocols documentation;Publications;receptor;Regulation;Reporter;Research;Resolution;Role;Schizophrenia;selective expression;sensor;Signal Transduction;single nucleus RNA-sequencing;Source;Stains;Structure of choroid plexus;Surface;Techniques;Testing;Therapeutic Intervention;Tight Junctions;Tissues;tool;Training;Traumatic Brain Injury;two-photon;Vascular Endothelial Cell;Vascularization;Visualization

PROJECT_TITLE: Investigations of cAMP-dependent brain-barrier permeability in choroid plexus


ED_INST_TYPE: OVERALL MEDICAL

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Sensory input interacts with hard-wired genetic programs to change the way brain cells in the central nervous system wire together through synapses, however, a comprehensive and principled understanding of neural circuit plasticity is not yet available because current experimental technologies only offer small glimpses of this complex process. It is also unclear to what degree molecular changes within diverse brain cell types precede or follow changes in synaptic connectivity. Here, I utilize cutting-edge methods in single-cell genomics and viral barcoding to systematically map how auditory input changes gene expression and local synaptic connectivity relationships within the primary auditory cortex of mice.

PI_NAMEs: NEVUE, ALEXANDER  (contact)

PROJECT_TERMS: Acceleration;Address;Anatomy;Architecture;Auditory;Auditory area;Auditory system;Bar Codes;Behavior;Biological;Brain;brain cell;Brain Stem;career;cell cortex;Cell Death;Cell Nucleus;Cell Shape;cell type;Cells;Central Nervous System;Chromosome Mapping;Complex;Data;Development;Diphtheria Toxin;diphtheria toxin receptor;Electrophysiology (science);Engineering;excitatory neuron;experience;Gene Expression;Genetic;genome-wide;Goals;Hair Cells;Hearing;hearing impairment;Homeostasis;in vivo;Individual;inhibitory neuron;Labyrinth;Maps;Measures;Methodology;Methods;Modeling;Molecular;Molecular Genetics;molecular shape;mouse model;Mus;neural;neural circuit;new technology;normal hearing;novel;Outcome;Pathway interactions;postnatal;postsynaptic neurons;presynaptic;Process;programs;Property;Rabies virus;rabies virus barcoding;Research Personnel;RNA;Sampling;Sensory;sensory cortex;Sensory Deprivation;Sensory Hair;Sensory impairment;sensory input;Shapes;single cell genomics;single nucleus RNA-sequencing;Slide;Synapses;Technical Expertise;Techniques;Technology;Therapeutic Intervention;Time;Tissue-Specific Gene Expression;Tissues;tool;Viral

PROJECT_TITLE: Postnatal experience shapes gene expression and connectivity development in the cortex


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: Project Narrative:  Environmental contexts and associated drug cues can elicit craving, and subsequent drug-seeking behaviors after prolonged abstinence periods may contribute to the recurrent chronic relapsing nature of alcohol addiction (O’Brien et al. 1992, O’Brien et al. 1998). There is a critical need for therapeutic treatments for alcohol-seeking behaviors. This project's long-range goals will help to understand mechanisms that underlie 5-HT7 receptors' ability to suppress (agonist) or potentiate (antagonist) conditioned cue expression of alcohol-seeking and would contribute to establishing 5-HT7 agonists are viable pharmacotherapeutics to reduce alcohol craving.

PI_NAMEs: HAUSER, SHEKETHA RENAY (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Abstinence;Agonist;alcohol abuse therapy;alcohol craving;Alcohol dependence;alcohol seeking behavior;Alcoholism;Alcohols;Alzheimer's Disease;antagonist;Anxiety;attenuation;Behavior;Behavior Control;Chronic;Cognitive;craving;Cues;Data;Development;Dorsal;Drug Addiction;Drug Controls;drug craving;drug reward;drug seeking behavior;Drug Withdrawal Symptoms;Environment;experimental study;Exposure to;extracellular;Goals;Human;Incubated;knock-down;Knowledge;Laboratories;Measures;Mediating;Mental Depression;Microdialysis;Modeling;Nature;neural circuit;neurochemistry;Nucleus Accumbens;overexpression;painful neuropathy;Pharmaceutical Preparations;pharmacologic;Play;Precipitating Factors;prolonged abstinence;receptor;receptor expression;Recovery;Recurrence;Regulation;Relapse;relapse prevention;Research;response;Rodent;Role;Serotonin;serotonin 7 receptor;Site;System;Techniques;Testing;Therapeutic;therapeutic target;Time;Viral Vector;Western Blotting

PROJECT_TITLE: Serotonin-7 receptors and Alcohol-seeking Behaviors

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

PHR: Recent advances in dynamical systems theory suggests that the best way to understand the mechanism of neural computation may not lie at the level of individual neurons, but instead through the dynamics of neural populations. To leverage this new perspective, we need tools that can model the dynamics of neural circuits, but the best models currently available have significant limitations that make their dynamical estimates inaccurate, and therefore poorly suited to give interpretable insight into neural computation. I propose a novel neural network architecture that could solve this problem, allowing computational models to learn accurate dynamics from neural data arising from single or multiple interacting neural circuits and helping us infer how neural computations are built by populations of neurons in the brain.

PI_NAMEs: VERSTEEG, CHRISTOPHER  (contact)

PROJECT_TERMS: Address;Affect;Architecture;Area;artificial neural network;autoencoder;Behavior;Biological;biological systems;Brain;cognitive process;Communication;Complex;Computer Models;Coupled;Coupling;Data;Data Set;Decision Making;Differential Equation;Dimensions;Dorsal;dynamic system;Electrodes;frontal lobe;Generations;Geometry;Goals;Human;in silico;Individual;innovation;insight;Intuition;invention;Investigation;Learning;Measurement;Methodology;Methods;Modeling;Monkeys;Motor;Motor Cortex;Movement;multidimensional data;neural;neural circuit;neural model;neural network;neural network architecture;Neural Network Simulation;neuromechanism;neuronal patterning;Neurons;Neurosciences;novel;Output;Pattern;Performance;Population;Publishing;reconstruction;recurrent neural network;Rewards;Speed;System;Systems Theory;terabyte;Testing;theories;Time;time interval;tool;Training;Variant

PROJECT_TITLE: Developing novel neural network tools for accurate and interpretable dynamical modeling of neural circuits


ADMINISTERING_IC: FD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: Newark

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: We propose to develop an integrated toolbox to provide the necessary scientific, technological, and regulatory contextual understanding for a continuous production of monoclonal antibodies, via an experimentally validated process model. Such an approach will enable both industry and the FDA to make more science- and risk-based decisions with respect to continuous bioprocessing. We will work closely with our network of industrial partners and with NIIMBL, vendors, and the FDA to maximize overall success.

PI_NAMEs: IERAPETRITOU, MARIANTHI  (contact)

PROGRAM_OFFICER_NAME: WANG, VIVIAN

PROJECT_TITLE: Advancing continuous biomanufacturing of monoclonal antibodies using an experimentally validated modeling platform


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC FOUNDATION

PHR: Project Narrative “Modeling the disease burden and cost-effectiveness of screening and treatment for non-alcoholic fatty liver disease in type 2 diabetes patients” will provide a better understanding of an under-recognized yet common comorbidity of patients with type 2 diabetes (T2D) in the US. As part of this project, we will develop and validate a computer-based model that can be used to estimate and project the burden of non-alcoholic fatty liver disease (NAFLD) in T2D patients. We will then apply the model to identify the most cost-effective medications and the optimal screening strategy for NAFLD, in order to improve the medical care and quality of life for millions of patients suffering from diabetes and NAFLD.

PI_NAMEs: DASARATHY, SRINIVASAN ;ROTHBERG, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Modeling the Disease Burden and Cost-Effectiveness of Screening and Treatment for Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes Patients

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Digestive Diseases;Maternal Health;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Maternal immune tolerance is essential for fetal development, but the regulatory mechanisms underlying fetal immune cell development remain largely undefined. Built upon our recent novel discovery of the maternal MDSC-IFNγ axis at the maternal-fetal interface orchestrated by the gut microbiome, we propose a multidisciplinary approach to interrogate how the gut microbome modulates fetal immune regulation via regulation of the MDSC-IFNγ axis. The findings from our studies will provide the framework for future studies of targeted manipulation of the gut microbiome to modulate these immune pathways to promote fetal immune cell development.

PI_NAMEs: ZENG, MELODY Y (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Affect;Antibiotics;Antibodies;ARG2 gene;Bacteria;Caring;Cell Separation;Cells;Child;Coupled;Development;Diet;Down-Regulation;Exhibits;fetal;Fetal Development;Fetal Growth;Fetal Liver;Fetal Resorption;Fetal Tissues;Fetus;Future;Genes;Genetic;genetic signature;Germ-Free;Goals;gut bacteria;gut inflammation;gut microbiome;Health;Human;Immune;Immune response;Immune system;Immune Tolerance;Immunoglobulin G;immunoregulation;imprint;in utero;Incidence;Infection;interdisciplinary approach;Interferon Activation;Interferon Type I;Interferon Type II;Interferons;Intestines;Investigation;Lead;Malignant Neoplasms;Maternal-Fetal Exchange;Methodology;murine colitis;Mus;Myeloid-derived suppressor cells;Neonatal;Neutropenia;neutrophil;Newborn Infant;novel;offspring;Pathway interactions;Pharmaceutical Preparations;Placenta;Placentation;postnatal;Pre-Eclampsia;Predisposition;Pregnancy;Pregnancy Complications;Pregnancy Rate;pregnant;Pregnant Women;Premature Birth;prenatal;progenitor;recruit;Regulation;response;Role;Shapes;Signal Transduction;Spiral Artery of the Endometrium;Spontaneous abortion;System;T-Lymphocyte;Techniques;Therapeutic;Tissues;transcriptome;transcriptomics;trend;United States;Uterus;women's treatment

PROJECT_TITLE: Immune regulation by the gut microbiome at the maternal-fetal interface


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Lung;Organ Transplantation;Pediatric;Precision Medicine;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

ORG_STATE: AR

PHR: Respiratory viral infections are a leading source of infectious complications in children undergoing hematopoietic cell transplantation and solid organ transplantation. The current diagnostic methods do not distinguish true disease or predict patients at risk for progression to severe disease. We will use a multi-faceted approach focusing on the virus and the host response to define biomarkers that risk stratify patients and generate evidence- based pediatric guidelines for personalized management.

PI_NAMEs: ENGLUND, JANET A;HEROLD, BETSY C.;MARON, GABRIELA MARIA;STEINBACH, WILLIAM J (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;adaptive immune response;age group;Antibodies;Antibody Response;biobank;Biological Assay;Biological Markers;biomarker identification;Blood;Blood specimen;Bronchiolitis;case control;Child;Childhood;Clinical;cohort;Common Cold;Communicable Diseases;Coronavirus;COVID-19;COVID-19 pandemic;Data;Dedications;Detection;Diagnosis;Diagnostic;Diagnostic Procedure;Disease;Disease Outcome;Disease Progression;disorder risk;Early Intervention;Enrollment;Epidemiology;epidemiology study;Evaluation;evidence base;Future;Gene Expression Profile;Genotype;graft function;Graft Survival;Guidelines;Health;Hematopoietic Stem Cell Transplantation;high risk;Hospitalization;Human Metapneumovirus;Immune;Immune response;immunological status;Immunologics;improved;Infection;Influenza A virus;Influenza B Virus;Innate Immune Response;interdisciplinary approach;Learning;longitudinal, prospective study;Lower respiratory tract structure;Metagenomics;Morbidity - disease rate;mortality;Nose;novel;nucleic acid detection;Nucleic Acids;optimal treatments;organ transplant recipient;Organ Transplantation;Otitis Media;Outcome;outcome prediction;Para-Influenza Virus Type 3;parainfluenza virus;Participant;pathogen;patient population;patient stratification;patient subsets;Patients;personalized management;Pneumonia;post-transplant;predictive marker;predictive modeling;predictive tools;Prevalence;progression risk;prospective;Research;respiratory;Respiratory syncytial virus;Respiratory Tract Diseases;response;Rhinovirus;Risk;risk prediction;risk stratification;Sampling;screening;Sinusitis;Site;Solid;Sore Throat;Source;species difference;Specimen;T-Lymphocyte;Testing;tool;Transplant Recipients;Transplantation;treatment strategy;Upper respiratory tract;vaccine trial;Viral;Viral Load result;Viral Respiratory Tract Infection;Virus;Virus Diseases

PROJECT_TITLE: Multi-center Evaluation of the Threat of Established and Emerging Respiratory Viral Infections in Pediatric Transplant Recipients

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Mental Health;Precision Medicine;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative The purpose of this R01 study is to conduct a comprehensive and state-of-the-art meta-analysis of Cognitive Behavioral Therapy, Relapse Prevention, and other Cognitive-Behavioral Intervention (CBIs) efficacy, moderated efficacy, and mediating processes when delivered to populations with alcohol or other drug use disorders. The project will incorporate a range of methodological advancements in meta-analysis and will inform clinical and methodological recommendations on: 1) CBI implementation and delivery, 2) optimal endpoints for measuring CBI effect, and 3) defining and understanding recovery in the context of evidence-based treatment.

PI_NAMEs: MAGILL, MOLLY  (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Abstinence;Adolescent;Agreement;alcohol and other drug;Alcohol consumption;Alcohol or Other Drugs use;alcohol use disorder;Alcohols;Behavior Therapy;Behavioral;Benchmarking;biopsychosocial;brief intervention;Centers for Disease Control and Prevention (U.S.);Clinical;clinical application;Clinical Trials;clinically significant;Cognitive;Cognitive Science;Cognitive Therapy;Consumption;contextual factors;Coping Behavior;Coping Skills;cost;craving;Data;Development;direct patient care;Drug Use Disorder;Economic Burden;Effectiveness;efficacy evaluation;Evidence based treatment;experience;Failure;Family;follow-up;Frequencies;Future;Guidelines;Health;Heavy Drinking;Heterogeneity;implementation intervention;improved;Individual;individual patient;interest;International;Intervention;intervention effect;Justice;Longevity;Manuscripts;Measures;Mediating;Mediator;medical specialties;Mental Health;Meta-Analysis;Methodology;Methods;Modeling;mortality;Motivation;National Institute on Alcohol Abuse and Alcoholism;novel;Outcome;Outcome Study;Outcomes Research;Participant;patient subsets;Patients;personalized care;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Population;preservation;Process;promote resilience;Provider;Psyche structure;psychosocial;Public Health;Publishing;Quality of life;randomized trial;randomized, clinical trials;Recommendation;Recovery;Relapse;relapse prevention;Reporting;Research;Sample Size;Sampling;Self Direction;Self Efficacy;Services;Social support;Subgroup;substance abuse treatment;Substance Use Disorder;success;Surveys;Symptoms;text searching;Therapeutic;therapy development;Time;Trauma;treatment adherence;Treatment Efficacy;treatment services;United States;United States Substance Abuse and Mental Health Services Administration;Update;Work;World Health Organization;young adult

PROJECT_TITLE: Optimal Endpoints in Clinical Trials of Cognitive Behavioral Interventions for AOD: An Aggregate and Individual Patient Data Meta-Analysis

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative The objective of our research is to determine the cellular and molecular basis for age-related breast tumorigenesis and whether age-related breast cancer is due to dysfunction of mammary stem cells and can be prevented through pharmacological interventions. Our research will establish a foundation for the prevention of age-related breast cancer, which should particularly benefit the population at high risk for invasive breast cancer.

PI_NAMEs: SUN, LUZHE  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Age;age related;Aging;aging population;aging related;Basal Cell;Biological Markers;Breast Cancer Prevention;Breast Cancer Risk Factor;Breast Epithelial Cells;breast tumorigenesis;cancer initiation;CDKN2A gene;Cell Aging;Cells;Clinical Research;Clinical Trials;Cyclin-Dependent Kinase Inhibitor 2A;cytotoxic;Data;DNA Damage;Dose;efficacy evaluation;Epithelial Cells;experience;Exposure to;Feedback;fisetin;Foundations;Frequencies;Functional disorder;Future;Gene Expression Profile;Gene set enrichment analysis;Genes;Gland;Goals;high risk;Human;Hyperplasia;In Vitro;in vivo;in vivo regeneration;Incidence;Inflammation;Inflammatory Response;inhibitor;innovation;Intervention;Lesion;Malignant Breast Neoplasm;mammary;Mammary Duct;Mammary gland;Mammary Gland Parenchyma;Mammary Neoplasms;Mammary Tumorigenesis;Mammospheres;Mediating;Molecular;mouse model;multidisciplinary;Mus;Natural regeneration;neoplastic;novel;old mice;Older Population;Oncogenes;Oncogenic;Ontology;Organoids;Patients;pharmacologic;Phenotype;Population;Postmenopause;Premenopause;prevent;Prevention;Prevention strategy;Proliferating;promoter;Publishing;repaired;Reporting;Research;RNA Splicing;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Sirolimus;stem cells;stem-like cell;Stratum Basale;Stromal Cells;Testing;transcriptome sequencing;transdifferentiation;triple-negative invasive breast carcinoma;tumor initiation;tumor xenograft;tumorigenesis;Variant;whole genome;Woman;Work

PROJECT_TITLE: Aging-associated mammary cancer-initiating cells


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Contraception/Reproduction;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative Although approximately 130 million babies are born every year worldwide, we have limited understanding of how normal term labor progresses. This project will use a recently developed technology (Electromyometrial Imaging, EMMI) to build the first-ever "normal term atlas" describing the detailed electrophysiology of uterine contractions during normal term labor. In the long term, EMMI holds great potential to monitor labor and test the effectiveness of strategies to reduce labor complications.

PI_NAMEs: CAHILL, ALISON G;SCHWARTZ, ALAN L;WANG, YONG  (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: 3-Dimensional;Abdomen;Address;Anatomy;Atlases;Body of uterus;Cervical;Cervix Uteri;Cesarean section;Clinical;clinical investigation;Clinical Trials;Data;effectiveness evaluation;effectiveness testing;Electrodes;Electrophysiology (science);Enrollment;experience;Fetal Development;Fetus;First Labor Stage;Future;Geometry;Human;Image;imaging study;Imaging technology;indexing;individual patient;Intervention;Knowledge;Labor Complications;Magnetic Resonance Imaging;Maps;Measures;Monitor;neuroimaging;new technology;non-invasive imaging;Nulliparity;Patients;Pattern;Phase;Physiological;Positioning Attribute;Postpartum Hemorrhage;Pregnancy;Pregnant Women;Premature Birth;prepregnancy;prevent;Procedures;Publishing;Resolution;Shapes;sheep model;Signal Transduction;spatiotemporal;Surface;Technology;temporal measurement;Testing;Time;tool;translational study;treatment strategy;Uterine Contraction;Uterus;Vaginal delivery procedure;Woman

PROJECT_TITLE: The three-dimensional spatiotemporal dynamics of human uterine contractions using electromyometrical imaging (EMMI)

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Diabetes;Immunotherapy;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Cell transplantation is a promising treatment option to replace nonfunctioning hormone secreting organs like endocrine pancreas. We propose a prevascularized encapsulation platform with local sustained immunosuppression to protect transplanted islet from immune rejection, avoiding adverse effects of systemic immunosuppression regimens, while providing an environment conducive for successful engraftment. This system has potential for a breakthrough in islet transplantation to significantly improve care and quality of life of patients with type 1 diabetes.

PI_NAMEs: GRATTONI, ALESSANDRO  (contact);KENYON, NORMA S.

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Address;Adoption;Adverse effects;Affect;Allogenic;allotransplant;Anoxia;Beta Cell;Biodistribution;Biometry;Blood Vessels;Caring;Cell Physiology;Cell Survival;Cell Therapy;Cell Transplantation;Cells;Clinical;clinical development;clinical investigation;Clinical Research;clinical translation;Collaborations;conditioning;Cutaneous;Data;design;Diabetes Mellitus;diabetic;Disease;Dose;Drug Delivery Systems;Drug Implants;Drug Kinetics;efficacy evaluation;efficacy study;Encapsulated;Engraftment;Environment;euglycemia;Event;Exposure to;flexibility;Future;Goals;Graft Rejection;Homing;Hormone secretion;Hydrogels;Hypoxia;Immune;immunoregulation;immunosuppressed;Immunosuppression;Immunosuppressive Agents;Implant;improved;In Situ;In Vitro;innovation;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans;Islets of Langerhans Transplantation;Life;life span;manufacture;Membrane;Mesenchymal Stem Cells;Microspheres;minimally invasive;Nanoporous;neovascularization;nonhuman primate;Nutrient;Organ;Osmosis;Oxygen;Patients;Pharmaceutical Preparations;pharmacokinetic model;Pharmacologic Substance;Physiological;Polymers;Positioning Attribute;post-transplant;pre-clinical;Procedures;prototype;Publishing;Pump;Quality of life;Regimen;Research;Rest;Safety;scaffold;Site;Stem cell transplant;stem cells;subcutaneous;Supporting Cell;System;Technology;technology platform;Testing;Therapeutic;Thinness;Tissue Engineering;Toxic effect;Translating;Transplantation;Transplantation Immunology;Transplantation Surgery;Vascularization;Work

PROJECT_TITLE: Vascularized NICHE with local immunosuppression for cell replacement for Type 1 diabetes


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: Los Angeles

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative Long noncoding RNAs (lncRNAs) are a novel class of RNAs representing up to 80% of the genome, though only a handful of lncRNAs have been demonstrated with function in the most common and deadly brain tumor, glioblastoma (GBM). I have identified a novel lncRNA, linc02454, upregulated by GBM chemotherapy, that modulates the chemosensitivity of GBM. I plan to characterize the manner by which chemotherapy increases linc02454, and the manner by which linc02454 affects treatment sensitivity, to better understand the role of lncRNAs following adjuvant therapy, while acquiring the training in transcriptional regulation necessary to develop as a surgeon-scientist.

PI_NAMEs: ATTENELLO, FRANK  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: 12q14;Adjuvant Therapy;Affect;ATAC-seq;Binding;Biological Assay;Biology;Bioluminescence;Brain Neoplasms;career;career development;Cell Culture Techniques;Cell Cycle;Cell Line;Cell Survival;Cells;chemokine receptor;Chemoresistance;chemotherapy;Chromatin;Chromosomes;Clinical Trials;Combined Modality Therapy;CpG Island Methylator Phenotype;CXC Chemokines;Data;Data Set;Development Plans;Diagnostic;DNA;Down-Regulation;Epigenetic Process;epigenetic regulation;Excision;experience;experimental study;Exposure to;Feasibility Studies;Fluorescent in Situ Hybridization;fractionated radiation;Functional dependence;Funding;Gene Amplification;Gene Expression;Genes;Genetic;Genetic Epistasis;Genetic Transcription;Genome;genomic locus;Glioblastoma;Glioma;Goals;Hypermethylation;improved;In Vitro;in vivo;International;knock-down;Malignant Neoplasms;Mass Spectrum Analysis;Meditation;Mentors;Mentorship;Methylation;Mus;neoplastic cell;Neurosurgeon;novel;Operative Surgical Procedures;Patients;Phenotype;Primary Brain Neoplasms;Radiation;Radiation therapy;Recurrence;Recurrent tumor;Regimen;Regulation;Repression;Research;Resistance;response;RNA;RNA methylation;RNA-Protein Interaction;Role;Sampling;Scientist;skills;standard care;Surgeon;Techniques;temozolomide;Testing;The Cancer Genome Atlas;therapeutic target;therapy resistant;Training;Transcript;Transcriptional Regulation;transcriptome sequencing;Treatment Efficacy;treatment response;tumor;United States National Institutes of Health;Untranslated RNA;Work;Xenograft procedure

PROJECT_TITLE: Examining the Role of a Novel Long Noncoding RNA, linc02454, in Resistance of Glioblastoma to Temozolomide


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Pediatric

ORG_CITY: MOUNT PLEASANT

ORG_NAME: CENTRAL MICHIGAN UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE – Children’s Hospital of Michigan The proposal is relevant to public health because Children’s Hospital of Michigan (CHM) as a clinical site will  bring a racially, ethnically, and socioeconomically diverse population of critically ill children as research  participants to the CPCCRN. This diverse population will allow personalized treatment of sepsis-induced  MODS to be fully investigated. CHM as a clinical site is relevant to the NICHD’s mission that all children have  the chance to fulfill their potential to live healthy and productive lives free from disease or disability.

PI_NAMEs: MEERT, KATHLEEN L. (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Address;Admission activity;American;American College of Surgeons;anakinra;antagonist;Anti-Inflammatory Agents;Area;Award;Beds;Blocking Antibodies;Burn Centers;Cardiac;cardiac intensive care unit;Cardiovascular system;Caring;Child;Childhood;Clinical;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Collection;Contracts;Critical Care;Critical Illness;Critically ill children;Data;Data Coordinating Center;Development;Dimensions;disability;Disease;Doctor of Philosophy;Dose;Enrollment;Ethnic Origin;expectation;experience;Faculty;Family;Functional disorder;functional status;Funding;Genetic;Goals;Good Clinical Practice;Granulocyte-Macrophage Colony-Stimulating Factor;Health;health related quality of life;high risk;Hospitals;immune function;Immunophenotyping;immunoregulation;immunosuppressed;Individual;Infant;Information Systems;innovation;Institution;Institutional Review Boards;Intensive Care;Interleukin 6 Receptor;Interleukin-1 Receptors;Lead;Leadership;Life;Medical;Medical center;Medicine;meetings;Mentored Clinical Scientist Development Program;Mentors;Methods;Michigan;mid-career faculty;Mission;Morbidity - disease rate;mortality;Multiple Organ Failure;National Institute of Child Health and Human Development;operation;Operative Surgical Procedures;Organ;Outcome;Participant;patient population;Pediatric Hospitals;pediatric trauma;Performance;personalized medicine;Physician Executives;Population Heterogeneity;Procedures;Productivity;professor;Program Development;programs;Protocols documentation;Public Health;Publications;Race;racial diversity;Randomized, Controlled Trials;Recombinants;Research;Research Personnel;Research Training;Resources;sample collection;Science;Scientist;Sepsis;Services;Severities;Site;socioeconomics;square foot;success;Survivors;Talents;tertiary care;tocilizumab;Translational Research;Trauma;trauma centers;Universities;Utah;Work

PROJECT_TITLE: Collaborative Pediatric Critical Care Research Network - Clinical Site


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Excessive alcohol use is the 5th-leading risk factor for premature death and disability. Unfortunately, recent societal phenomena might contribute to worsening alcohol use disorder recognition and care. In a large, national population, this study seeks to examine the impact of high-deductible health plans and the 2019 novel coronavirus pandemic on alcohol use disorder treatment access, outcomes, and disparities.

PI_NAMEs: WHARAM, JAMES FRANKLIN (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: 2019-nCoV;Acceleration;Accident and Emergency department;Adoption;Adult;Adverse event;adverse outcome;Affect;Affordable Care Act;aged;alcohol availability;Alcohol consumption;alcohol risk;alcohol use disorder;Alcoholic Intoxication;Alcohols;American;barrier to care;Behavior Therapy;behavioral health;Bipolar Disorder;Businesses;Caring;Cessation of life;cohort;Cohort Studies;comparison group;coronavirus pandemic;cost;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;Data;data infrastructure;Deductibles;design;Diabetes Mellitus;Diagnosis;diagnostic criteria;disability;Disparity;Disparity population;Economic Burden;Economics;Emergency Situation;Enrollment;ethnic minority population;Ethnic Origin;experience;Family;Financial Hardship;Funding;Goals;Health;health care settings;Health Insurance;health plan;health savings account;Health Services Accessibility;Healthcare;high risk;improved;Insurance;Insurance Benefits;Insurance Carriers;interest;Interruption;long term recovery;Low income;Malignant Breast Neoplasm;Marketing;Measures;member;Modification;Outcome;outcome disparities;Outcome Study;pandemic impact;parity;payment;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Policy Making;Population;post-pandemic;Poverty;pre-pandemic;premature;Privatization;Quasi-experiment;Race;racial minority population;Readiness;reduced alcohol use;Regulation;rehabilitation service;Reporting;Research Design;Resources;Risk;Risk Factors;rural dwellers;rurality;Sampling;Series;Services;social;Societal Factors;Statutes and Laws;stay-at-home order;Subgroup;Substance Use Disorder;Survival Analysis;Time;Treatment Cost;treatment disparity;Treatment outcome;trend;Uninsured Medical Expense;United States

PROJECT_TITLE: Impact of high deductible health plans and COVID-19 on alcohol use disorder treatment access, outcomes, and disparities


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative The proposed project is relevant to public health because it introduces a robust new approach of using smartphone-based training to scale up tobacco control evidence-based interventions (EBIs). By delivering training through smartphones, the potential reach of the EBIs is multiplied over what can be achieved with in- person training. It is relevant to NCI's mission of addressing tobacco control and increasing the availability of low-cost, portable technologies for cancer control in low and middle-income countries.

PI_NAMEs: NAGLER, EVE M (contact)

PROGRAM_OFFICER_NAME: VANDERPOOL, ROBIN CLINE

PROJECT_TERMS: Address;Adoption;Adult;Affect;Area;arm;base;Cancer Control;Cellular Phone;Cessation of life;Characteristics;cluster randomized design;Cluster randomized trial;Communities;comparative effectiveness study;comparative effectiveness trial;comparison control;Consolidated Framework for Implementation Research;contextual factors;cost;Data;design;Education;Effectiveness;Ensure;Evidence based intervention;experience;flexibility;Goals;Hybrids;implementation cost;implementation fidelity;implementation framework;improved;India;Individual;innovation;insight;Intervention;Interview;Learning;low and middle-income countries;Methods;Mission;Modeling;mortality;novel strategies;Outcome;Penetration;Persons;Population;portability;primary outcome;programs;Public Health;public policy on tobacco;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;reduce tobacco use;Research;Resource-limited setting;Resources;Role;role model;Rural;rural area;scale up;School Teachers;Schools;secondary outcome;smartphone application;Smoke;Smokeless;Societies;Structure;teacher;Technology;Time;Tobacco;tobacco control;tobacco products;Tobacco use;Tobacco Use Cessation;tobacco-free;Training;Variant;virtual;Work

PROJECT_TITLE: Scaling up tobacco control in India: Comparing smartphone to in-person training for implementing an evidence-based intervention to reduce tobacco use among schoolteachers

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: The goal of this research is to use machine learning algorithms to work out which  genetic differences in the genomes of Alzheimer’s disease (AD) patients might have  caused their disease. We will do this by learning computational models of how genes are  controlled by genetic sequence and other genes. The proposed study will discover what genes,  pathways and molecular mechanisms are involved in AD, which will provide novel  therapeutic targets for AD patients.

PI_NAMEs: KNOWLES, DAVID ARTHUR;RAJ, TOWFIQUE  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: abeta accumulation;Address;Affect;Aging;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Architecture;ATAC-seq;Autopsy;Base Sequence;Biological;Brain;causal variant;Cell Physiology;cell type;Cells;ChIP-seq;Chromatin;Clinical Data;Code;Computer Models;Data;Data Collection;Data Set;deep learning;deep learning model;Development;Disease;diverse data;DNA;DNA Sequence;empowerment;endophenotype;epigenomics;Ethnic Origin;exome sequencing;Family;Frequencies;frontal lobe;functional genomics;Future;Gene Expression;gene regulatory network;Genes;Genetic;genetic analysis;genetic architecture;Genetic Risk;genetic variant;Genome;genome sequencing;genome wide association study;genome-wide;genomic data;Genomics;Genotype-Tissue Expression Project;Goals;Health Care Costs;Histones;Human Genetics;Immune;in silico;Individual;insertion/deletion mutation;insight;Investments;large scale data;Learning;Life;Link;Linkage Disequilibrium;Machine Learning;machine learning algorithm;machine learning method;Maps;Medical;Meta-Analysis;Methods;Microglia;Modality;Modeling;Molecular;molecular phenotype;monocyte;mRNA Expression;multi-ethnic;Multiomic Data;Mutagenesis;Neighborhoods;Neurodegenerative Disorders;neuropathology;new therapeutic target;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;Nucleic Acid Regulatory Sequences;Pathogenesis;Pathway interactions;Peripheral;Personal Satisfaction;Persons;Population;Post-Transcriptional Regulation;protective allele;protein aggregation;Quantitative Trait Loci;rare variant;Regulation;Research;risk variant;RNA;RNA Processing;RNA Splicing;side effect;Signal Transduction;Single Nucleotide Polymorphism;single-cell RNA sequencing;Sorting;Statistical Models;Susceptibility Gene;Techniques;Technology;Testing;therapeutic development;Therapeutic Studies;therapeutic target;tool;Training;trait;transcriptome;transcriptome sequencing;transcriptomics;Untranslated RNA;Vacuum;Variant;variant detection;whole genome;Work

PROJECT_TITLE: Learning the Regulatory Code of Alzheimer's Disease Genomes


NIH_SPENDING_CATS: Congenital Structural Anomalies;Pediatric;Prevention;Rare Diseases

ORG_CITY: Rockville

ORG_NAME: SOCIETY FOR DEVELOPMENTAL BIOLOGY

ORG_STATE: MD

PHR: Cohn, DH Project Narrative This is an application for partial support of the 2020 Structural Birth Defects Meeting, the 12th such meeting held since 2001. Support for the subsequent two meetings, in 2022 and 2024 is also requested to firmly establish this conference in support of research in this important area. The discoveries presented at this meeting will drive new collaborations and new directions to accelerate translation of basic knowledge and insights from clinical and laboratory studies of the etiology of structural birth defects into the development of new, innovative, and efficacious strategies for the molecular diagnosis, treatment, and prevention of these disorders.

PI_NAMEs: COHN, DANIEL H (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Acceleration;Accounting;Area;Basic Science;Biological;career;Cementation;Centers for Disease Control and Prevention (U.S.);Child;Clinical;Clinical Research;Collaborations;Communities;Congenital Abnormality;congenital heart abnormality;Craniofacial Abnormalities;Craniosynostosis;Development;Diagnosis;Diaphragmatic Hernia;Disabled Persons;Disease;disorder prevention;Elevator;Epidemiology;Etiology;Event;Family;Fostering;Funding;Future;Genetic;Goals;graduate student;Grant;improved;Incidence;Infant Mortality;innovation;insight;interest;Knowledge;Laboratory Study;Life;Limb Development;Medical;meetings;member;Mentors;Mission;model organism;Molecular;Molecular Diagnosis;National Institute of Child Health and Human Development;Neural Tube Defects;new technology;next generation;novel strategies;Oral;Patients;peer;Physicians;Postdoctoral Fellow;posters;prevent;Prevention;programs;Public Health;Recording of previous events;Research;Research Personnel;Research Support;Role;Scientist;scoliosis;Severities;skeletal disorder;Socioeconomic Status;Speed;Strategic Planning;Structural Congenital Anomalies;symposium;Training Support;translational approach;Translations;Travel;Underrepresented Minority;United States;United States National Institutes of Health;Woman;working group

PROJECT_TITLE: Structural Birth Defects Meetings 12th-14th

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ORG_CITY: WASHINGTON

ORG_NAME: NATIONAL ASSN /CNTY/CITY/HLTH/OFFICIALS

ORG_STATE: DC

PHR: Project Narrative According to the Centers for Disease Control and Prevention, consuming contaminated foods is the annual cause of 47.8 million illnesses, 128,000 hospitalizations, and 3,000 deaths just in the U.S., more than half of foodborne illness outbreaks are associated with food from restaurants. More than 3,000 state, local, territorial, and tribal (SLTT) agencies have primary responsibility to regulate the retail food and foodservice industries in the United States. If this project is funded, NACCHO and CFP will work collaboratively with the Retail Food Safety Regulatory Association Collaborative to further the capacity of SLTT agencies to improve retail food safety and reduce foodborne illness across the U.S.

PI_NAMEs: LI, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: NIESEN, MARIBETH

PROJECT_TITLE: Retail Food Safety Regulation Association Collaboration (U18) [Clinical Trial Not Allowed]


NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Clinical Research;Infectious Diseases;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE:  Extremely premature neonates, who are at a critical stage of central nervous system development, endure the highest risk of being exposed to chorioamnionitis and develop cerebral palsy. I have identified that chorioamnionitis-induced perinatal alterations of Heme-oxygenase-1 (HO-1) pathway in the developing rat brain correlate with neuroinflammation and my proposed studies will investigate how these alterations contribute to immune-mediated perinatal white matter injury. By gaining insight into this previously not studied pathway in perinatal white matter injury, defining novel molecular mechanisms, innovative diagnostic and therapeutic interventions will be possible.

PI_NAMEs: OZEN, MAIDE  (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: Acute;Adult;Anti-Inflammatory Agents;Apoptotic;behavioral study;Biological Response Modifiers;Biology;Brain;Brain Injuries;career;career development;Cell Death;Cells;Central Nervous System;Cerebral Palsy;Cerebrum;chemokine;Circulation;Cognitive deficits;Complex;cytokine;Cytoprotection;Data;Development;Development Plans;Diagnostic;Disease;Doctor of Medicine;Doctor of Philosophy;Ensure;Environment;Enzymes;executive function;Exposure to;extreme prematurity;Foundations;Future;Gene Proteins;Grant;heme oxygenase-1;high risk;Histopathology;Homeostasis;Immune;Immune response;immunoregulation;Impaired cognition;improved;Inflammatory;innovation;insight;intraamniotic infection;Investigation;Iron;Knowledge;Learning;Macrophage;Measures;Mediating;medical schools;Mentors;Mentorship;Microglia;Modeling;Molecular;monocyte;Mononuclear;Myelogenous;Myeloid Cells;Neonatal;neonate;nervous system development;Neurodevelopmental Impairment;Neuroimmune;neuroimmunology;neuroinflammation;Neurosciences;Neurosciences Research;novel;novel marker;Oligodendroglia;Oxidative Stress;Pathway interactions;Pattern;Pediatrics;Perinatal;Perinatal Brain Injury;Peripheral;Phenotype;Physicians;Placenta;Premature Birth;Premature Infant;preterm newborn;professor;Program Development;Rattus;Reactive Oxygen Species;receptor;Regulation;Research;Research Personnel;response;restoration;Role;Scientist;Secondary to;Signal Transduction;skills;spatiotemporal;targeted treatment;Technical Expertise;Techniques;Testing;TFRC gene;Therapeutic Intervention;Time;Training;Training Programs;Translational Research;Universities;Up-Regulation;white matter;white matter injury

PROJECT_TITLE: The role of chorioamnionitis-induced perinatal alterations of Heme-oxygenase-1 (HO-1) pathway on neuroinflammation and neonatal white matter injury

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_DEPT: GENETICS

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project narrative Over 1.7 million people are diagnosed with cancer in the United States every year. We strive to understand how these cancers develop by studying how mistakes are made when cells duplicate their genetic material. The detailed knowledge of the mechanisms that prevent these mistakes, may contribute to the development of future cancer therapies.

PI_NAMEs: SMOGORZEWSKA, AGATA  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Aphidicolin;biological adaptation to stress;cancer therapy;Cell Cycle;Cell Death;Cell model;Cells;chromatin immunoprecipitation;Chromosomal Instability;Chromosome Fragile Sites;conditional knockout;Data;Defect;Development;Diagnosis;DNA;DNA biosynthesis;DNA Damage;DNA lesion;DNA Repair Gene;DNA replication fork;Elements;Enzymes;Essential Genes;Event;Excision;Functional disorder;Future;Genes;genetic approach;Genetic Materials;Genetic Transcription;Genome;genome integrity;Genome Stability;Genomic Instability;Genomics;Goals;Hematopoietic System;Human;hydroxyurea;inhibitor;insight;Knockout Mice;Knowledge;liquid chromatography mass spectrometry;Maintenance;Malignant Neoplasms;Mammalian Cell;Mass Spectrum Analysis;Mediating;Mediator;member;Modeling;mouse model;multicatalytic endopeptidase complex;Mus;Mutagenesis;Mutate;novel;nuclease;Okazaki fragments;Oncogenic;Outcome;Participant;Persons;Pharmaceutical Preparations;Phosphorylation;Positioning Attribute;prevent;Process;protein degradation;Proteins;Publishing;Recovery;recruit;Regulation;Regulatory Pathway;repaired;Repetitive Sequence;Replication Initiation;replication stress;Research;response;Ribonucleotides;Role;Signal Transduction;Single-Stranded DNA;Site;Stress;stress management;Structure;System;Techniques;termination factor;Testing;Travel;tumor;ubiquitin-protein ligase;Ubiquitination;United States;Work

PROJECT_TITLE: Understanding Replication Stress Response in Mammalian Cells

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


NIH_SPENDING_CATS: Cardiovascular;Congenital Structural Anomalies;Heart Disease;Pediatric

ORG_CITY: HERSHEY

ORG_DEPT: DERMATOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE Organ formation and tissue patterning requires collective cell behaviors driven by planar cell polarity (PCP), a conserved biological pathway essential for early human development. Deficiencies in PCP function contribute to severe developmental disorders such as spina bifida and congenital heart defects, and patterning defects of the inner ear and skin. The proposed program of research will uncover fundamental mechanisms of PCP regulation and reveal how mutations in PCP components contribute to human disease.

PI_NAMEs: STAHLEY, SARA N (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Adhesions;Adhesives;Anterior;Behavior Control;Biological;Biological Models;Biology;Cadherins;Cardiomyopathies;cell behavior;Cell Communication;Cells;ciliopathy;Complex;Congenital Heart Defects;Defect;Development;developmental disease;Dimerization;Disease;Embryo;Epidermis;Failure;Family member;fly;Genetic;genetic approach;Goals;Hair;Human;Human Development;human disease;Image;Impairment;in vivo;insight;Intercellular Junctions;Labyrinth;Lateral;Maintenance;Mediating;molecular assembly/self assembly;Molecular Biology;Mus;Mutation;Neural tube;Neural Tube Defects;novel;Organ;Pathogenicity;Pathway interactions;Patients;Pattern;planar cell polarity;programs;Protein Biochemistry;Proteins;Regulation;Research;Role;Signal Pathway;Skin;Spinal Dysraphism;Tissues;trafficking;Work

PROJECT_TITLE: Cadherin regulation of planar polarity

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]