ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Of the 800,000 cancer patients who qualify for checkpoint blockade therapy each year, nearly 700,000 fail to respond. The purpose of this project is to identify molecules from gut bacteria that promote an anti-tumor response to checkpoint blockade therapy and discover their mechanisms of action. The results will lead to more effective cancer therapeutics that will increase the number of cancer patients who respond to immunotherapy.

PI_NAMEs: GAZZANIGA, FRANCESCA SMYLIE (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: anti-cancer;anti-CTLA4;anti-PD-1;anti-PD-L1;anti-PD-L1 therapy;anti-tumor immune response;Antibiotics;Antibodies;Antitumor Response;Bacteria;Bioinformatics;Biological;Blocking Antibodies;Breeding;cancer cell;Cancer Model;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;Cell Communication;Cell Physiology;Cells;Cellular Assay;checkpoint therapy;Chemistry;Clinic;clinical translation;Coculture Techniques;Collaborations;Colon;Combined Modality Therapy;commensal microbes;Data;Dendritic Cells;Disease;draining lymph node;Drug Industry;Environment;Epithelium;Exclusion;experience;Flow Cytometry;gastrointestinal epithelium;Germ-Free;Gnotobiotic;Goals;gut bacteria;gut microbes;gut microbiota;Human Microbiome;Immune;immune checkpoint;immune checkpoint blockade;Immune response;Immune system;Immunotherapy;In Vitro;in vivo;Individual;Industry;Intestines;Ion-Exchange Chromatography Procedure;Knockout Mice;Label;Learning;Legal patent;Macrophage;Malignant Neoplasms;Mediating;medical schools;mesenteric lymph node;Microbe;microbiota;Microfluidics;Motivation;Mus;novel therapeutics;Organoids;Pathway interactions;Patients;PD-1 blockade;pharmacologic;Play;pre-clinical;professional atmosphere;programmed cell death ligand 1;programmed cell death protein 1;Qualifying;Research;response;Role;Running;Signal Pathway;Signaling Molecule;Site;skills;stem;Sterility;Structure;Surface;T-bet protein;T-Lymphocyte;Testing;Therapeutic;Therapeutic Uses;therapeutically effective;Training;transcriptome sequencing;Translations;tumor;Tumor Immunity;Work

PROJECT_TITLE: Identifying gut bacterial molecules and mechanisms that promote an anti-tumor response to immunotherapy


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Orphan Drug;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Narrative: Metaplastic breast cancer (MpBC) is a rare, aggressive, highly lethal subtype of breast cancer, and the main therapeutic option for metastatic MpBC remains systemic chemotherapy, despite known resistance to most chemotherapy drugs. This proposal seeks to explore a targeted combinatorial approach consisting of simultaneous inhibition of two major pathways implicated in MpBC, the nitric oxide synthase and the phosphoinositide 3-kinase pathways, to eradicate primary tumor growth and metastasis. Our proposal will investigate the mechanisms by which these two pathways inhibit primary tumor growth and assess interactions between various cells in the tumor and its environment using specimens derived from murine MpBC models.

PI_NAMEs: CHANG, JENNY C-N (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: 3-Phosphoinositide Dependent Protein Kinase-1;Accounting;Acetates;Adhesions;Aftercare;alpelisib;Apoptosis;Arginine;Biopsy;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;cancer subtypes;Catalytic Domain;Cell Communication;cell growth;Cell Line;cell motility;cell type;Cells;Chemoresistance;chemotherapy;clinical prognosis;Clinical Trials;combinatorial;Combined Modality Therapy;Complement;Cytotoxic agent;Data;Data Analyses;Detection;Development;Disease;Drug resistance;druggable target;efficacy evaluation;Environment;Event;Exhibits;Funding;gain of function;Genes;Growth;Health;hormone therapy;Image;imaging system;Immunocompetent;Immunofluorescence Immunologic;in vivo;inhibitor;intercellular communication;Invaded;Investigation;Lymphoid Cell;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Metaplastic carcinoma of the breast;Metastatic Neoplasm to the Lung;Modeling;Molecular;mouse model;multimodal data;Mus;Mutate;Mutation;Myeloid Cells;Neoplasm Metastasis;neoplastic cell;Nitric Oxide;Nitric Oxide Synthase;Nitric Oxide Synthetase Inhibitor;NOS2A gene;omega-N-Methylarginine;Oncogenic;outcome prediction;participant enrollment;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Pharmaceutical Preparations;Phosphatidylinositols;Phosphotransferases;PIK3CA gene;Population;pre-clinical;Pre-Clinical Model;Primary Neoplasm;Production;Prognosis;Prognostic Factor;Property;Protein Isoforms;Proto-Oncogene Proteins c-akt;PTEN gene;Publishing;Radiation therapy;Refractory;Regimen;Resistance;Resolution;response;Ribosomal Proteins;ribosome profiling;Ribosomes;RNA;RNA-Protein Interaction;Role;Signal Pathway;Specimen;stem cell self renewal;Stromal Cells;SUM-159 Breast Cancer Cell Line;Surveys;Survival Rate;taxane;Testing;Therapeutic;therapeutically effective;therapy resistant;TP53 gene;transcriptome sequencing;transcriptomics;Translations;Treatment Efficacy;treatment response;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;tumorigenesis

PROJECT_TITLE: Dual targeting of PI3K and NOS pathways in Metaplastic BreastCancer (MBC)

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebral Palsy;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Precision Medicine;Rehabilitation;Stroke

ORG_CITY: Columbus

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed research is highly relevant to public health because it adds to our fundamental knowledge about reaching and grasping behaviors of the upper extremity in infants with and without hemiparetic cerebral palsy. The application of new measurement methods, knowledge about healthy and impaired spontaneous arm and hand use, and response to treatment will enhance health and help reduce disability for the millions of individuals of cerebral palsy and other physical disabilities who need rehabilitation. Thus, the proposed research is consistent with NIH mission that pertains to the development of fundamental knowledge to extend healthy life and develop translational clinical research to help reduce the burdens of illness and disability.

PI_NAMEs: HEATHCOCK, JILL C. (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Affect;Age;age group;Age Months;arm;arm movement;Assessment tool;Behavior;Behavior assessment;Behavioral;Brachial Paresis;burden of illness;Cerebral Palsy;Child;Child Development;Childhood;Childhood stroke;Clinical;Clinical Assessment Tool;clinical practice;Clinical Research;clinical translation;Clinical Trials;clinically relevant;Code;Cognition;cohort;Communication;constraint induced movement therapy;cost;Data;data sharing;Development;Diagnosis;Dimensions;disability;dosage;Dose;Environment;Equipment and supply inventories;evidence base;Exercise;Exploratory Behavior;Feedback;feeding;follow-up;Frequencies;Funding;Future;Gestures;Goals;grasp;Hand;Hand functions;Health;hemiparesis;human old age (65+);Impairment;improved;indexing;Individual;Individual Differences;individualized medicine;Infant;innovation;Knowledge;Language;Life;longitudinal dataset;Lower Extremity;Measurement;Measures;Methodology;Methods;Mission;Motor;Motor Activity;motor impairment;Motor Skills;Movement;National Institute of Neurological Disorders and Stroke;Nervous System Physiology;Neurologic Deficit;neurological rehabilitation;novel;Outcome;Outcome Measure;Parents;Paresis;peer;perinatal ischemic stroke;personalized medicine;Phase;phase III trial;Physical Function;Physical Rehabilitation;physically handicapped;Play;Population;Property;prospective;Psychological reinforcement;Psychometrics;Public Health;Randomized, Controlled Trials;Recovery;rehabilitation research;Rehabilitation therapy;remote assessment;Reporting;Reproducibility;Research;response;Risk;Scientific Advances and Accomplishments;Selection for Treatments;skills;Standardization;Statistical Models;Stroke;Technology;Testing;Time;Toddler;tool;Toy;treatment effect;treatment response;treatment strategy;United States National Institutes of Health;Upper Extremity;virtual assessment;Walking;Work

PROJECT_TITLE: Development of upper extremity behavioral assessment methods for reach-and-grasp and physical rehabilitation

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE This renewal T32 grant application for a Pulmonary Development and Disease Pathogenesis Training Program seeks to continue support to recruit and train outstanding pre-doctoral and post-doctoral candidates, preparing them to advance science and make discoveries that improve the diagnosis and treatment of pulmonary diseases, enabling them to become future research leaders in research and medicine. This Program meets a critical national need to increase the quantity and quality of young investigators who can apply cellular, molecular, and genetic strategies to the study of lung disorders. There is an ever-increasing loss of M.D. and Ph.D. candidates from academic-scientific careers at a time in which unparalleled opportunities exist to identify mechanisms of underlying disease pathogenesis and to develop novel biomarkers, diagnostics, and treatment strategies to improve human health.

PI_NAMEs: MCCORMACK, FRANCIS XAVIER;TRAPNELL, BRUCE C;WHITSETT, JEFFREY A (contact);WOODS, JASON C

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: TR

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research

ORG_CITY: ROCHESTER

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PI_NAMEs: THAKAR, JUILEE ;VAN WIJNGAARDEN, EDWIN  (contact)

PROGRAM_OFFICER_NAME: BROWN, PATRICK

PROJECT_TERMS: Academia;Active Learning;Address;Affinity;analytic epidemiology;Area;Award;base;career;Career Choice;career development;career networking;Clinical;Clinical Research;Clinical Sciences;college;Communities;community engagement;computer science;Coupling;Credentialing;Data;data integration;Data Science;deaf;Development;Development Plans;Discipline;doctoral student;Education;education research;educational atmosphere;Educational Status;Ensure;Environment;Evaluation;experience;Exposure to;Faculty;Feedback;flexibility;Geography;Goals;graduate student;Health system;Immersion;improved;Industry;Informatics;innovation;insight;Institution;interest;Internships;Joints;Laboratories;Learning;learning community;Medical Students;Mentors;Minority-Serving Institution;Modeling;multidisciplinary;National Research Service Awards;Outcome;Parents;Population;population health;post-doctoral training;Postdoctoral Fellow;pre-doctoral;programs;recruit;Research;Research Institute;Research Personnel;Research Training;Science;skills;Structure;Students;TNFSF15 gene;Training;training opportunity;Training Programs;Translational Research;trend;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities;Workforce Development;working group

PROJECT_TITLE: NRSA Training Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF TORONTO

ORG_STATE: ON

ORG_ZIPCODE: M5S 1S8

PHR: PROJECT NARRATIVE Infections by fungi pose an escalating health problem, with a global disease burden affecting billions and killing more than 1.5 million people annually. Successful completion of this project will deliver one or more optimized chemical compounds that can kill hard to treat fungi, especially cryptococcal species, and make current antifungal drugs work better by blocking resistance mechanisms. By providing valuable leads for future development into drugs, it will ultimately help generate greatly needed new, more effective antifungal antibiotics.

PI_NAMEs: BROWN, LAUREN ELAINE;COWEN, LEAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Achievement;acquired drug resistance;Address;Affect;Affinity;analog;Animals;anti-fungal agents;Anti-fungal Antibiotics;Azoles;Bacterial Infections;Binding;Biochemical;Biological Assay;Biological Process;Biology;blood-brain barrier permeabilization;burden of illness;cancer therapy;Candida albicans;Cells;Cessation of life;Chemicals;Chemistry;Clinical;Collaborations;Computational algorithm;Conserved Sequence;Cryptococcal Meningitis;Cryptococcus;Cryptococcus neoformans;Death Rate;design;Development;Disease;Dose;Dose Limiting;drug candidate;Drug Kinetics;Drug resistance;drug structure;Economics;Eukaryota;experience;flexibility;Funding;fungus;Future;Genomics;Goals;Health;HIV;HSP 90 inhibition;Human;immune function;improved;in vitro Assay;Infection;inhibitor;insight;Investigation;Lead;lead optimization;Left;Life;life span;Machine Learning;Malaria;Malignant Neoplasms;Maps;Measures;Metabolic;Methods;microorganism;Modeling;Molecular Biology;Molecular Chaperones;Molecular Conformation;Molecular Medicine;Molecular Target;Monitor;mouse model;multidisciplinary;Mus;Mycoses;N-terminal;National Institute of Allergy and Infectious Disease;Nucleotides;Organ Transplantation;Outcome;Pathogenesis;pathogenic fungus;Pathogenicity;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Population;pre-clinical;preservation;Property;Proteins;Regimen;Resistance;resistance mechanism;Resource-limited setting;Route;Schedule;Sepsis;small molecule;standard of care;Structure;Structure-Activity Relationship;targeted treatment;Testing;Therapeutic Intervention;Time;Toxic effect;Tuberculosis;Work

PROJECT_TITLE: Targeting Hsp90 in cryptococcal fungal pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-F(83)]


ADMINISTERING_IC: MD

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

ORG_STATE: MA

PHR: PROJECT NARRATIVE Latinx (im)migrant populations experience a significant behavioral health burden while utilizing behavioral health treatment at lower rates than non-Latinxs, indicating an unmet treatment need. This study will investigate the role of social relationships – which are disrupted in the (im)migration process – in shaping behavioral health treatment-seeking in Puerto Ricans displaced by Hurricane Maria, who endorse high levels of behavioral health distress. The results of this study can inform culturally-congruent outreach efforts and treatment services for this community to improve behavioral health outcomes, while also suggesting routes to reduce future treatment disparities for Latinx groups.

PI_NAMEs: HODGES, JAMES  (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Affect;Back;behavioral health;Boston;Clinical;college;Communities;community advisory board;community engaged research;Community Services;Complex;cost;cultural competence;Data;Data Analyses;Demographic Factors;design;Development;Disease;Distress;economic cost;Ensure;Environment;experience;Face;Family;Fellowship;Future;Health;health service use;Health Services;Hurricane;Immigrant;Impairment;improved;Individual;Institution;Interpersonal Relations;Interruption;Interview;Island;Knowledge;knowledge base;Latinx;Latinx population;Lead;Mental Health;Mentors;Mentorship;Methodology;Migrant;migration;Outcome;outreach;Parents;Pathway interactions;Pattern;Play;Population;Process;prospective;psychological distress;Puerto Rican;Qualitative Methods;Research;Research Design;Research Personnel;Resources;Role;Route;Schools;service utilization;Services;Shapes;social;social influence;social integration;Social Network;social relationships;Social support;Social Work;Societies;Stress;stressor;substance use;Substance Use Disorder;Surveys;System;theories;Time;Training;treatment disparity;Treatment outcome;treatment services;United States

PROJECT_TITLE: The Role of Social Relationships in Behavioral Health Treatment-Seeking in Post-Maria Puerto Rican Migrants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: KANSAS CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative - Overall The Kansas PKD Research and Translation Core Center will provide the core services infrastructure and educational environment to support research in polycystic kidney disease as a part of the national effort to develop new reagents and essential biomaterials for biomarker discovery and drug target identification to advance new therapies for testing in clinical trials ultimately for improved patient outcomes.

PI_NAMEs: WALLACE, DARREN P. (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Articulation;Autosomal Dominant Polycystic Kidney;base;Basic Science;Biochemistry;Biocompatible Materials;Biological Markers;biomarker discovery;Biomedical Research;Cancer Center;Cell model;Cell Physiology;Cellular biology;Clinical;clinical development;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Communities;Cyst;Development;Disease;Drug Targeting;drug testing;Education;educational atmosphere;Educational workshop;Effectiveness;Environment;Foundations;Goals;Grant;Growth;improved;Infrastructure;innovation;insight;Institution;inter-institutional;Interdisciplinary Study;Kansas;Kidney;Medical center;meetings;Methods;Mission;multidisciplinary;new technology;novel therapeutic intervention;novel therapeutics;Pathogenesis;patient oriented;Patient-Focused Outcomes;Patients;Polycystic Kidney Diseases;Productivity;programs;Reagent;Recording of previous events;recruit;Research;Research Methodology;Research Personnel;Research Support;Resource Sharing;Resources;Rodent Model;Series;Services;Site;skills;summer student;symposium;Technology;Testing;therapeutic target;tool;translational medicine;Translations;Universities


PI_NAMEs: CALVET, JAMES P (contact)

PROJECT_TERMS: Abnormal Cell;Advisory Committees;Advocate;Area;Autosomal Dominant Polycystic Kidney;Biochemistry;Biocompatible Materials;Biological Markers;biomarker discovery;Biomedical Research;Cancer Center;Cell model;Cell Proliferation;Cellular biology;clinical development;Clinical Investigator;Clinical Research;clinical translation;Clinical Trials;Collaborations;Communication;Communities;Cyst;Decision Making;Development;Disease;Disease Progression;drug testing;Education;Educational workshop;Effectiveness;Ensure;Evaluation;falls;FDA approved;Fluids and Secretions;Funding;Genetic Models;Grant;Growth;improved;innovation;Institution;Kansas;Malignant Neoplasms;member;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Pathway interactions;patient oriented;Patient-Focused Outcomes;Patients;Play;programs;Reagent;Recording of previous events;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Review Committee;Rodent Model;Role;Scientist;Services;Signal Transduction;Site;summer student;symposium;Techniques;Technology;Testing;therapeutic target;tolvaptan;Translational Research;Translations;Work

PROJECT_TITLE: Kansas PKD Research and Translation Core Center - Administrative Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Overall Narrative Our Center will work to reveal how genes and environment interact with neuroimmune cells and signaling to shape aspects of brain development that may go awry in neuropsychiatric illness. We will do this by deploying scientific approaches from neuroscience, immunology, and genomics, spanning levels from molecules to behavior and leveraging both mouse and marmoset model species, as well as human tissues and cellular models.

PI_NAMEs: CARROLL, MICHAEL CRAIG;STEVENS, BETH ANN (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent brain development;Adolescent Development;Adult;Astrocytes;Autopsy;Basal Ganglia;Behavior;Behavioral;behavioral phenotyping;Biological;Biological Assay;Biological Models;Biology;Brain;Brain Mapping;Brain region;brain tissue;Callithrix;CD47 gene;Cell model;cell type;Cells;childhood adversity;Cognition;Cognitive;cognitive development;Complement;Complement component C4;Complement component C4a;Complex;course development;critical period;Decision Making;Development;Disease;Distant;Environment;Environmental Risk Factor;Etiology;frontal lobe;Functional disorder;Gene Expression;Generations;Genes;Genetic;Genetic Risk;genetic risk factor;Genetic Transcription;Genomics;Goals;Human;human stem cell-derived;human tissue;Immune;Immunology;Incidence;Individual;innovation;interdisciplinary collaboration;interest;Intervention;Investigation;Link;Mediating;member;Mental disorders;Mental Health;Modeling;Molecular;mouse model;Multimedia;Mus;neural;Neuroanatomy;Neurodevelopmental Disorder;Neuroimmune;Neuroimmunomodulation;Neurons;neuropsychiatry;Neurosciences;non-genetic;nonhuman primate;novel;novel diagnostics;novel strategies;novel therapeutic intervention;Outcome;outreach;overexpression;Parents;Pathway interactions;pharmacologic;Phenotype;Physiological;Physiology;Play;Population;Populations at Risk;postnatal;psychiatric symptom;psychogenetics;Research;Research Personnel;Resources;response;Rewards;Risk;Risk Assessment;Risk Factors;risk variant;Role;Route;Sampling;Schizophrenia;schizophrenia risk;Shapes;Signal Transduction;social;Social Behavior;Social Workers;Source;Specificity;symposium;Synapses;synaptic function;synaptic pruning;synaptogenesis;teacher;Testing;Thalamic structure;Therapeutic;therapeutic evaluation;Tissue Model;tool;Training;training opportunity;transcriptome;vulnerable adolescent;web site;Work;young adult

PROJECT_TITLE: Neural-immune Mechanisms and Synaptic Connectivity in Psychiatric Illness


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease;Prevention

PROJECT_TERMS: 3-Dimensional;Age;Alcohol consumption;Autosomal Dominant Polycystic Kidney;Beta-N-Acetylglucosaminidase;Biocompatible Materials;Biological Assay;Biological Markers;biomarker discovery;biomarker panel;Biomaterials Research;Biomedical Research;Blood;Blood Urea Nitrogen;Caffeine;CCL2 gene;cell immortalization;Cell Line;Cell model;Cell Proliferation;Cells;Chronic Kidney Failure;Clinic;Clinical;Clinical Research;cohort;Collagen;Collection;comorbidity;Creatinine;Cyst;Cyst Fluid;Cystic Fibrosis Transmembrane Conductance Regulator;Databases;detection platform;Development;Diagnosis;Disease;DNA;drug testing;Duct (organ) structure;Early Diagnosis;Early Intervention;effective therapy;electrical measurement;Epithelial Cell Proliferation;Epithelial Cells;Epithelial cyst;exosome;experimental analysis;Family;Fluids and Secretions;Formalin;Freezing;Gene Mutation;Gene Targeting;Generations;Genes;Goals;Growth;high resolution imaging;Hospitals;Human;human tissue;Immunoassay;In Vitro;in vitro Assay;in vitro Model;Individual;Industry;Injury to Kidney;interstitial cell;Investigation;Kansas;Kidney;kidney cell;Knock-out;Laboratories;LCN2 gene;Measurement;Medical History;model organism;Molecular;Monitor;monolayer;MRI Scans;mutant;Mutation;Nephrons;novel;novel therapeutics;observational cohort study;Paraffin Embedding;Participant;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;Plasma;post gamma-globulins;potential biomarker;predictive marker;Preparation;Provider;Race;rat KIM-1 protein;Reagent;Recording of previous events;recruit;renal damage;repository;Research;Research Personnel;response;Risk;Risk Factors;Sampling;Serum;Services;sex;Siblings;Site;Smoking History;specific biomarkers;Testing;Therapeutic;Therapeutic Agents;therapeutic evaluation;Therapeutic Intervention;Time;Tissue Embedding;Tissues;Training;Translating;Translational Research;Translations;treatment response;Universities;urinary;Urine;volunteer

PROJECT_TITLE: Biomedical Research Core 1 - Biomarkers, Biomaterials, and Cellular Models Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Schizophrenia;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TITLE: Administrative Core (Core A)


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Services;Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE The five-year focus of the University of Rochester Clinical and Translational Science Institute is on “translational research without walls,” moving beyond the physical and virtual confines of institutions, by accelerating integration of translational research with the Learning Health System, expanding innovative approaches to dissemination and implementation and creating a translational research data ecosystem that seamlessly integrates data across the translational spectrum, linking our research and clinical data warehouses and expanding education efforts across our pilot programs to achieve translational research data and analytic excellence. We will enhance translational research collaborations at the local and national levels across the spectrum of stakeholders, extending community-based participatory research, facilitating multidisciplinary team formation and expanding our local and national collaborations. We will educate the next generation of translational science workforce leaders, expanding our approaches to ensure competence in the collaborative, technical, and regulatory skills necessary to accelerate the translation of high impact research to clinical applications, and we will catalyze the development, implementation and dissemination of methods and processes that advance translational research locally and nationally across the CTSA Consortium. Page 173 Project Narrative

PI_NAMEs: WILSON, KAREN M.;ZAND, MARTIN S (contact)

PROJECT_TERMS: Academia;Acceleration;Address;Advisory Committees;analytical method;Area;Awareness;Basic Science;Clinical;Clinical and Translational Science Awards;clinical application;Clinical Data;clinical data warehouse;clinical practice;Clinical Research;Clinical Sciences;Clinical Trials;cohort;Collaborations;Communities;community based participatory research;community engaged research;community engagement;Community Participation;Competence;Computer software;Consent;Data;Data Analytics;Data Collection;data ecosystem;data integration;Data Science;Dedications;Degree program;Development;digital;Dissemination and Implementation;Ecosystem;Education;Educational Materials;Educational Models;Enrollment;Ensure;Evaluation;Fostering;handheld mobile device;Health;health care delivery;health equity;Health system;Healthcare;Healthcare Systems;Heterogeneity;implementation research;implementation science;improved;Industry;Informatics;informatics tool;Information Systems;innovation;Institution;Institutional Review Boards;laboratory experiment;Language;Learning;life span;Link;Mediation;Medical center;member;Mentors;Methods;Mission;Multi-Institutional Clinical Trial;multidisciplinary;next generation;novel;novel therapeutics;Ontology;operation;Outcome;Outcome Measure;Participant;Patients;Population;population based;population health;Positioning Attribute;practice-based research network;Process;programs;Public Health Informatics;Research;Research Design;research in practice;Research Methodology;Research Personnel;research study;sample collection;Sampling;Science;Site;skills;Speed;Standardization;study population;success;tool;Training;translational barrier;translational pipeline;Translational Research;translational scientist;Translations;Universities;virtual;virtual clinical trial;Vision;Visit;Workforce Development;working group

PROJECT_TITLE: The University of Rochester Clinical and Translational Science Award Hub


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Genetics;Human Genome;Kidney Disease;Pediatric;Polycystic Kidney Disease

PI_NAMEs: TRAN, PAMELA VIVIAN (contact)

PROJECT_TERMS: Address;Agreement;Alleles;Amino Acids;Animals;Autosomal Dominant Polycystic Kidney;autosome;Biocompatible Materials;Biological Assay;Biological Markers;biomarker identification;Biomedical Research;Breeding;C-terminal;Catalogs;Cell Culture Techniques;Cell model;Cell Nucleus;Cells;Cilia;Co-Immunoprecipitations;commercialization;Communities;Complement;Consult;Consultations;Contracts;Cryopreservation;Cyst;Data;Data Analyses;Databases;design;Development;Dietary Intervention;Disease;Drug Design;Drug Modelings;Drug or chemical Tissue Distribution;drug testing;Educational workshop;Engineering;Essential Drugs;Exhibits;experimental study;gene network;gene therapy;Genes;Genetic Models;Genetic study;Genomics;Goals;human disease;In Vitro;in vivo;innovation;insight;Institution;Investigation;Kansas;Kidney;Knock-out;Laboratories;Learning;Legal;LoxP-flanked allele;Maps;material transfer agreement;Medical;Medical center;Modeling;Molecular Target;mouse model;Multiprotein Complexes;Mus;Mutant Strains Mice;Mutation;next generation;novel;Organ Culture Techniques;Outcome;Pattern;Pharmaceutical Preparations;polycystic kidney disease 1 protein;pre-clinical;Pre-Clinical Model;Process;Reagent;Renal Tissue;repository;Research;Research Personnel;Resources;response;Rodent Model;service intervention;Services;single nucleus RNA-sequencing;single-cell RNA sequencing;Structure;testing services;therapeutic evaluation;therapeutic target;tool;trafficking;transcriptomics;Translations;Universities;Visualization;Work

PROJECT_TITLE: Biomedical Research Core 2 - Rodent Models & Drug Testing Core


PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent brain development;Adolescent Development;Adult;Astrocytes;Autopsy;Basal Ganglia;Behavior;Behavioral;behavioral phenotyping;Biological;Biological Assay;Biological Models;Biology;Brain;Brain Mapping;Brain region;brain tissue;Callithrix;CD47 gene;Cell model;cell type;Cells;childhood adversity;Cognition;Cognitive;cognitive development;Communication;Complement;Complement component C4;Complement component C4a;Complex;course development;critical period;Decision Making;Development;Disease;Distant;Environment;Environmental Risk Factor;Etiology;frontal lobe;Functional disorder;Gene Expression;Generations;Genes;Genetic;Genetic Risk;genetic risk factor;Genetic Transcription;Genomics;Goals;Human;human stem cell-derived;human tissue;Immune;Immunology;Incidence;Individual;innovation;interdisciplinary collaboration;interest;Intervention;Investigation;Link;Mediating;member;Mental disorders;Mental Health;Modeling;Molecular;mouse model;Multimedia;Mus;neural;Neuroanatomy;Neurodevelopmental Disorder;Neuroimmune;Neuroimmunomodulation;Neurons;neuropsychiatry;Neurosciences;non-genetic;nonhuman primate;novel;novel diagnostics;novel strategies;novel therapeutic intervention;Outcome;outreach;overexpression;Parents;Pathway interactions;pharmacologic;Phenotype;Physiological;Physiology;Play;Population;Populations at Risk;postnatal;psychiatric symptom;psychogenetics;Research;Research Personnel;Resources;response;Rewards;Risk;Risk Assessment;Risk Factors;risk variant;Role;Route;Sampling;Schizophrenia;schizophrenia risk;Shapes;Signal Transduction;social;Social Behavior;Social Workers;Source;Specificity;symposium;Synapses;synaptic function;synaptic pruning;synaptogenesis;teacher;Testing;Thalamic structure;Therapeutic;therapeutic evaluation;Tissue Model;tool;Training;training opportunity;transcriptome;vulnerable adolescent;web site;Work;young adult

PROJECT_TITLE: Astrocyte-neuron communication and vulnerability to mental illness


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: KNOXVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: PROJECT NARRATIVE The vaginal mucosa is a complex and understudied ecosystem. Despite the importance of the vaginal microbiota on reproductive health, the fundamental principles that govern microbial interactions and persistent colonization remain largely unknown. We will define the nutritional landscape and characterize the impact of nutrient acquisition and exchange on community dynamics during bacterial colonization and persistence within the vaginal mucosa.

PI_NAMEs: BURCHAM, LINDSEY RENAE (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Nutritional landscape and community interactions in the vaginal microbiome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Cystic Fibrosis;Diabetes;Genetics;Lung;Microbiome;Prevention;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Cystic fibrosis-related diabetes (CFRD) is a common complication of CF that leads to worse lung function and increased mortality. While it is understood that patients with CFRD have differences in their sputum cultured microbes, how their microbiome differs in CF patients with and without diabetes is not known. This proposal aims to study the microbiome in CFRD, the influencers of glycemic changes in CFRD, and how the microbiome changes with glycemic modification.

PI_NAMEs: BRENNER, LAURA N (contact)

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: Adult;Affect;Age;Antibiotics;Artificial Pancreas;autosome;bacterial community;Beta Cell;biobank;Biodiversity;Bionics;Blood Glucose;blood glucose regulation;Body mass index;Carbohydrates;career;Caring;Cell Physiology;Clinical;Clinical Investigator;clinical predictors;Clinical Research;Clinical Trials;Clinical Trials Design;Communities;Complex;Complication;Continuous Glucose Monitor;Coupled;Cross-Sectional Studies;Cystic Fibrosis;cystic fibrosis patients;cystic fibrosis related diabetes;Cystic Fibrosis Transmembrane Conductance Regulator;Development;Devices;Diabetes Mellitus;Diagnosis;Disease;Enrollment;Ethnic Origin;Etiology;European ancestry;Family;fecal microbiome;Feces;Funding;Genes;Genetic;Genetic Determinism;genetic predictors;genetic variant;Glucagon;Glucose;glycemic control;gut microbiome;Hyperglycemia;Hypoglycemia;improved;innovation;insight;instrument;Insulin;Insulin deficiency;Insulin Resistance;Intake;Intervention;Life;Life Expectancy;Linear Regressions;Link;Lung;Lung infections;lung microbiome;mathematical algorithm;Measures;Mediating;Mediation;Mendelian randomization;Mentors;metagenomic sequencing;Methods;Microbe;microbial;Microbial Taxonomy;microbiome;microbiome alteration;microbiome composition;microbiome research;Modeling;Modification;mortality;Mutation;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutritional status;Outcome;Pancreas;patient population;Patients;Pattern;Persons;polygenic risk score;Pseudomonas aeruginosa;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Quality of life;Randomized;randomized, clinical trials;Recommendation;Recording of previous events;Research;Resistance;response;Risk;Sampling;Serum;Shotguns;Sputum;Staphylococcus aureus;Structure;Surface;System;Techniques;Technology;Testing;Therapeutic;Time;Training;trait;treatment as usual;treatment response;trial design;type I and type II diabetes;Variant

PROJECT_TITLE: Genetics, glycemic control and the microbiome in cystic fibrosis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Kidney Disease;Patient Safety;Pediatric;Polycystic Kidney Disease

PI_NAMEs: YU, ALAN S (contact)

PROJECT_TERMS: Address;Advocacy;Age;Autosomal Dominant Polycystic Kidney;Belief;Biological Markers;biomarker discovery;Biomedical Research;Blood specimen;Caregivers;clinical development;Clinical Research;Clinical Trials;Clinical Trials Network;cohort;Collection;Common Data Element;Communities;compare effectiveness;Computer software;Consensus;Data Collection;data format;data harmonization;data integration;data modeling;Data Sources;data standards;Databases;design;Development;Disease;disease model;Disease Progression;diverse data;empowerment;Enrollment;Environment;exosome;experience;Family;Family member;Functional disorder;Goals;Health Personnel;Healthcare;Individual;Industry;information gathering;Infrastructure;instrument;International;Kansas;Longitudinal cohort;Maps;multiple data sources;Natural History;novel;novel therapeutics;Outcome;Outcome Measure;patient engagement;patient oriented;Patient-Focused Outcomes;Patients;Pharmacotherapy;Phenotype;preference;Prognostic Marker;programs;Protocols documentation;Race;recruit;Registries;Research;Research Personnel;Research Priority;Resources;Risk;shared decision making;Site;socioeconomics;Source;Standardization;Terminology;tolvaptan;tool;Translating;translational pipeline;Translations;trial design;trial readiness;Update;urinary;Urine;Work

PROJECT_TITLE: Biomedical Research Core 3 - Clinical Research Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Schizophrenia;Serious Mental Illness

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent brain development;Adolescent Development;Adult;Astrocytes;Autopsy;Basal Ganglia;Behavior;Behavioral;behavioral phenotyping;Biological;Biological Assay;Biological Models;Biology;Brain;Brain Mapping;Brain region;brain tissue;Callithrix;CD47 gene;Cell model;cell type;Cells;childhood adversity;Cognition;Cognitive;cognitive development;Complement;Complement component C4;Complement component C4a;Complex;course development;critical period;Decision Making;Development;Disease;Distant;Environment;Environmental Risk Factor;Etiology;frontal lobe;Functional disorder;Gene Expression;Generations;Genes;Genetic;Genetic Risk;genetic risk factor;Genetic Transcription;Genomics;Goals;Human;human stem cell-derived;human tissue;Immune;Immunology;Incidence;Individual;innovation;interdisciplinary collaboration;interest;Intervention;Investigation;Link;Mediating;member;Mental disorders;Mental Health;Modeling;Molecular;mouse model;Multimedia;Mus;neural;Neuroanatomy;Neurodevelopmental Disorder;Neuroimmune;Neuroimmunomodulation;Neurons;neuropsychiatry;Neurosciences;non-genetic;nonhuman primate;novel;novel diagnostics;novel strategies;novel therapeutic intervention;Outcome;outreach;overexpression;Parents;Pathogenesis;Pathway interactions;pharmacologic;Phenotype;Physiological;Physiology;Play;Population;Populations at Risk;postnatal;psychiatric symptom;psychogenetics;Research;Research Personnel;Resources;response;Rewards;Risk;Risk Assessment;Risk Factors;risk variant;Role;Route;Sampling;Schizophrenia;schizophrenia risk;Shapes;Signal Transduction;social;Social Behavior;Social Workers;Source;Specificity;symposium;Synapses;synaptic function;synaptic pruning;synaptogenesis;teacher;Testing;Thalamic structure;Therapeutic;therapeutic evaluation;Tissue Model;tool;Training;training opportunity;transcriptome;vulnerable adolescent;web site;Work;young adult

PROJECT_TITLE: Contributions of human C4A overexpression to schizophrenia pathogenesis.


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Schizophrenia

PROJECT_TITLE: Neuroimmune mechanisms of adolescent brain development and vulnerability


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Complementary and Integrative Health;Mental Health;Pediatric

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE Emotional well-being, which includes life satisfaction, life purpose, and positive emotions, is a key public health target. This proposal will develop a network of transdisciplinary researchers to understand and promote the effects of well-being on health, focusing on interrelated effects of health and well-being at the family level.

PI_NAMEs: HANMER, JANEL ;PROSSER, LISA A. (contact);WITTENBERG, EVE

PROGRAM_OFFICER_NAME: KING, TRACY

PROJECT_TERMS: Acceleration;Address;Affect;Age;Area;Attention;Caregivers;Centers for Disease Control and Prevention (U.S.);Child;Child Welfare;Childhood;Collaborations;Complex;Data Set;Dedications;design;Development;Discipline;Elderly;Evaluation;experience;Extended Family;Family;Family member;Family Relationship;family structure;Fostering;Funding;Generations;Goals;Health;Healthy People 2020;Improve Access;improved;indexing;Individual;informal caregiver;innovation;Institution;instrument;Intervention;Knowledge;Leadership;Learning;learning materials;Life;life span;Measurement;Measures;Mentors;Michigan;multidisciplinary;older adult;online resource;Online Systems;Ontology;Outcome;Outcome Measure;Parents;Patient Outcomes Assessments;Patient Self-Report;Patients;Personal Satisfaction;Persons;Pilot Projects;Population;positive emotional state;Public Health;Quality of life;Reporting;repository;Research;Research Activity;Research Personnel;Resource Development;Role;satisfaction;Training;U-Series Cooperative Agreements;Universities;Validation;Well in self;World Health Organization

PROJECT_TITLE: FAMILY WELL-BEING RESEARCH NETWORK (“FAM-NET”): Measuring Family Well-Being across the Lifespan


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Lung;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Vaccine Related

ORG_CITY: LEXINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: NARRATIVE Successful vaccination to prevent COVID-19 requires that people be willing to be vaccinated and that the vaccine be easy and accessible for them to obtain. Appalachian Kentucky is a region experiencing high vaccine hesitancy, an important challenge that need to be addressed to reduce COVID-19 rates. We will study ways of simultaneously addressing willingness to be vaccinated and vaccine accessibility and see if addressing those problems increases vaccine uptake.

PI_NAMEs: CARDARELLI, KATHRYN MARIE;KIVINIEMI, MARC T (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: 2019-nCoV;Achievement;Address;Adult;Affect;Appalachian Region;Behavior;Chronic Disease;Cluster randomized trial;Communicable Diseases;Communities;community based participatory research;community engaged approach;community engaged research;Community Health Aides;community organizations;community partnership;Community Relations;community-level factor;Complex;COVID-19;COVID-19 mortality;COVID-19 prevention;COVID-19 vaccine;distrust;Education;Educational Status;effectiveness measure;efficacy evaluation;Elements;Emerging Communicable Diseases;Epidemic;experience;Face;Failure;Future;Geography;Goals;Government;health care availability;health care delivery;health goals;Health Personnel;Health protection;implementation fidelity;indexing;Individual;Influenza;Infrastructure;inhibitor;Institution;Intervention;intervention delivery;Kentucky;Medical;Obesity;Obstructive Lung Diseases;Persons;Politics;Population;Population Characteristics;Poverty;Preparation;Prevalence;prevent;Process;Public Health;Research;Research Personnel;Respiratory Disease;Risk;Rural;Rural Population;Safety;SARS-CoV-2 infection;Series;Severe Acute Respiratory Syndrome;smoking prevalence;Source;System;tailored messaging;transmission process;trial design;Trust;Unemployment;uptake;Vaccinated;Vaccination;vaccination strategy;vaccine acceptance;vaccine access;vaccine delivery;vaccine efficacy;vaccine hesitancy;vaccine safety;Vaccines;vulnerable community;willingness

PROJECT_TITLE: K-VAC: Kentucky Vaccinating Appalachian Communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-V(90)]


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The mission of the Deep South Center to Reduce Disparities in Chronic Diseases is to promote health equity and reduce the burden of cardiometabolic diseases, including obesity, diabetes, and hypertension, among Black Americans and low-income populations in our tri-state region (i.e., Alabama, Mississippi, Louisiana). The Center represents a partnership between the University of Alabama at Birmingham, Tuskegee University, Pennington Biomedical Research Center, and the University of Mississippi Medical Center, along with regional non-academic partners to translate and sustain cardiometabolic research in real-world community and clinical settings. The Center is focused on expanding and diversifying the region’s research workforce, promoting equitable collaborations between researchers and non-academic partners, and advancing scientific discovery through synergistic research projects focused on multi-level, multi-domain interventions for the prevention, treatment, and management of cardiometabolic diseases in the Deep South.

PI_NAMEs: BASKIN, MONICA L.;CHERRINGTON, ANDREA L (contact);DUTTON, GARETH R

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Address;Alabama;Area;base;Belief;Biomedical Research;Black American;Cardiometabolic Disease;cardiometabolism;Chronic Disease;Clinical;clinical care;clinical center;Clinical Sciences;Collaborations;Communities;community engagement;community setting;comorbidity;Continuity of Patient Care;COVID-19 pandemic;Deep South;Development;Diabetes Mellitus;Disease;Disparity;disparity elimination;disparity reduction;effective intervention;Equity;ethnic minority;Evidence based intervention;experience;Foundations;Geographic Locations;Geography;Goals;Gossypium;Health Disparities Research;health disparity;health equity;health equity promotion;Health equity research;Heart;Hypertension;improved;Individual;Inequality;Infrastructure;innovation;Institution;Intervention;Knowledge;Leadership;Life Expectancy;Link;Louisiana;Low income;Low Income Population;Medical center;meetings;member;Mission;Mississippi;National Institute on Minority Health and Health Disparities;nutrition;Obesity;Outcome;Phase;Policies;Population;preference;Prevention;programs;Public Health;Race;racial minority;Reduce health disparities;Research;Research Personnel;Research Project Grants;Resources;Risk;Rural Community;Scientific Advances and Accomplishments;socioeconomics;synergism;Time;Translating;Translational Research;Translations;Universities


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: CHERRINGTON, ANDREA L (contact)

PROJECT_TERMS: Address;Administrator;Alabama;Area;Biomedical Research;Black American;Cardiometabolic Disease;Chronic Disease;Clinical;cohort;Collaborations;Communication;Communities;community advisory board;community center;community engagement;Consensus;Continuity of Patient Care;data sharing;Decision Making;Deep South;Development;Diabetes Mellitus;Disparity;disparity reduction;Doctor of Philosophy;Effectiveness;Ensure;Evaluation;evidence base;Evidence based intervention;Fostering;Geography;Goals;health disparity;health equity;health equity promotion;Hypertension;Infusion procedures;innovation;Institution;Knowledge;Lead;Leadership;Louisiana;Low Income Population;Measures;Medical center;meetings;Mission;Mississippi;Monitor;Obesity;operation;Performance;Pilot Projects;Prevention;Procedures;Productivity;Public Health;Recommendation;Reduce health disparities;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Scientific Advances and Accomplishments;Services;Site;Specific qualifier value;synergism;United States National Institutes of Health;Universities;Vision

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

PI_NAMEs: XIAO, JIN  (contact)

PROJECT_TERMS: Academia;advanced system;Area;career;career development;Characteristics;clinical practice;Collaborations;Communication;Communities;Complement;Data;digital health;Discipline;Dissemination and Implementation;diversity and inclusion;education research;Educational Curriculum;Elements;Ensure;Evaluation;Evolution;experience;Faculty;Goals;Health;health equity;Health system;Healthcare Systems;implicit bias;improved;Individual;Inequity;Informatics;innovation;Institution;Investigational Therapies;Knowledge;Lead;Leadership;Learning;Mentors;Methods;novel;Output;outreach;Pathway interactions;Performance;population health;Process;programs;Research;Research Personnel;Resources;Science;Scientific Advances and Accomplishments;Shapes;skills;success;System;Talents;Techniques;tool;Training;training opportunity;Translational Research;translational scientist;Translations;Universities;Wisconsin;Woman;Work

PROJECT_TITLE: Institutional Career Development Core


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: STONY BROOK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Pancreatic cancer causes approximately 40,000 deaths every year in the U.S.A. and currently there is no effective treatment for tumors that cannot be surgically removed. More than 90% of human pancreatic cancers are caused by mutations in a protein named KRAS that works together with another protein called PIK3CA to promote cancer growth. The goals of this proposal are to clarify how PIK3CA causes pancreatic cancer progression and to test whether a drug that blocks PIK3CA can be used to treat this deadly disease.

PI_NAMEs: LIN, RICHARD Z (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Ablation;alpelisib;Animals;anti-PD-1;anti-PD1 antibodies;Antibodies;cancer cell;Cancer Etiology;cancer infiltrating T cells;carboxylation;Cell Line;cell type;Cells;Cellular Metabolic Process;Cessation of life;Clinical;Clinical Trials;Data;Disease;effective therapy;efficacy testing;Environment;exhaustion;Exhibits;experimental study;Exposure to;FDA approved;Flow Cytometry;Gene Deletion;Genes;Genetic;genome-wide;Goals;Growth;Harvest;Histocompatibility Antigens Class I;Human;Hyperlipidemia;Hypoxia;immune checkpoint;Immune checkpoint inhibitor;immune clearance;Immune Evasion;Immune response;Immune system;Immunocompetent;Immunohistochemistry;Immunologics;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Implant;implantation;improved;in vivo imaging system;in vivo monitoring;Infiltration;inhibitor;instrument;KPC model;KRAS oncogenesis;KRAS2 gene;KRASG12D;Laboratories;Leucocytic infiltrate;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;Metabolic;metabolic profile;methylmalonyl-coenzyme A;MHC Class I Genes;mouse model;Mus;Mutation;Names;neoplastic cell;neutralizing antibody;Oncogenic;Operative Surgical Procedures;Pancreas;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacotherapy;PIK3CA gene;Pilot Projects;Play;programmed cell death ligand 1;programmed cell death protein 1;propionyl-coenzyme A;Proteins;Reporting;Resistance;RNA;Role;SCID Mice;side effect;Signal Transduction;single cell sequencing;T cell infiltration;T cell therapy;T-Cell Receptor;T-Lymphocyte;Target Populations;Testing;Therapeutic;Therapeutic Studies;therapeutic target;Treatment Protocols;tumor;tumor growth;tumor progression;tumor-immune system interactions;Up-Regulation;Work

PROJECT_TITLE: PIK3CA signaling and pancreatic cancer


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: GUTIERREZ, ORLANDO M (contact)

PROJECT_TERMS: Address;Adult;Age;Alabama;Applications Grants;Area;Attention;Award;Biomedical Research;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;career;Chronic Disease;Clinical;clinical center;Clinical Sciences;cohort;Collaborations;Communities;community based participatory research;community collaboration;community engagement;Community Health Aides;community organizations;community setting;comparative effectiveness;Competence;Consultations;contextual factors;Cost Analysis;cost effectiveness;Data;Data Collection;Dedications;Deep South;design;Development;Diabetes Mellitus;disability;Discipline;Disparity;disparity reduction;Dissemination and Implementation;dissemination science;Educational Intervention;effective intervention;Effectiveness;Ensure;Equity;Ethnic Origin;Evaluation;Evidence based intervention;Extramural Activities;Faculty;Fostering;Funding;Geographic Locations;Goals;Grant;Health Disparities Research;health equity;health equity promotion;Healthcare Systems;High Prevalence;Hypertension;implementation science;Individual;innovation;Institution;Intervention;investigator training;Kidney Diseases;Louisiana;Medical center;Mentors;Mentorship;Methodology;Mission;Mississippi;mortality risk;National Institute on Minority Health and Health Disparities;novel;Obesity;Outcome;Patients;Pilot Projects;Population;Postdoctoral Fellow;programs;Provider;Public Health;Publications;racial disparity;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;Science;sex;sexual identity;social health determinants;Socioeconomic Status;System;therapy development;Time;Training;Training Programs;Translating;Translational Research;translational study;Translations;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Investigator Development Core


NIH_SPENDING_CATS: Cancer;Pediatric

ORG_CITY: LA JOLLA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The Outreach Program To Inspire Minority and Underrepresented Students (OPTIMUS) at the University of California San Diego seeks to create an engaging cancer research fellowship program for underrepresented minority high school students in the local San Diego region. The program includes a mentored research experience, a cancer education curriculum, and a community outreach effort. Ultimately, OPTIMUS strives to increase diversity in cancer research and create a biomedical workforce that better reflects our diverse community.

PI_NAMEs: HALTER, CHRISTOPHER P;MURPHY, JAMES D (contact)

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: after-school program;Age;anti-cancer research;apprenticeship;Biomedical Research;California;Cancer Center;cancer education;cancer prevention;Caring;cohort;Collaborations;Communities;community based research;Community Outreach;Complement;Coupled;Dedications;design;Development;Education;Education and Outreach;education research;Educational Curriculum;Educational process of instructing;elementary school;Environment;experience;Exposure to;Faculty;Fellowship;Fellowship Program;fifth grade;Foundations;fourth grade;Funding;Future;Generations;Goals;Graduate Education;graduate student;Healthcare;High School Outreach;High School Student;Individual;interest;laboratory experience;Learning;Malignant Neoplasms;Medical Students;Mentors;minority student;Mission;Nonprofit Organizations;outreach;outreach program;Physicians;Population;Positioning Attribute;Postdoctoral Fellow;Professional Education;programs;Research;research faculty;Research Personnel;Running;Scholars Program;Science;Science, Technology, Engineering and Mathematics Education;sixth grade;skills;Students;success;supportive environment;Training;Underrepresented Minority;Underrepresented Students;Universities

PROJECT_TITLE: University of California San Diego Outreach Program To Inspire Minority and Underrepresented Students (OPTIMUS)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Obesity;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: BASKIN, MONICA L. (contact)

PROJECT_TERMS: Address;adult obesity;Alabama;Belief;Bioethics;Biomedical Research;Black American;Black race;burden of chronic illness;burden of illness;Cardiometabolic Disease;Cardiovascular Diseases;Chronic Disease;Communication;Communities;community academic partnership;community advisory board;community based participatory research;community engaged research;community engagement;community organizations;Complex;Continuity of Patient Care;Deep South;Diabetes Mellitus;Diagnosis;disease disparity;Disparity;disparity reduction;Economic Factors;editorial;Ensure;Equity;Faculty;Faith;Feasibility Studies;Goals;Government Agencies;Health;Health behavior;health care availability;health disparity;health equity;health equity promotion;Health Policy;Health Promotion;Hypertension;improved;Individual;innovation;Intervention;Leadership;Learning;Local Government;Louisiana;Low income;Low Income Population;Medical center;member;Mission;Mississippi;novel;Obesity;operation;Organization administrative structures;Outcome;Outcomes Research;Physical environment;Pilot Projects;Policies;Policy Maker;Population;preference;Prevalence;Prevention;Productivity;Public Health;Research;research data dissemination;Research Personnel;Research Project Grants;Resources;social factors;State Government;System;Target Populations;Time;time use;Training;Translating;Translational Research;Trust;Universities;web site;Work

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Prevention

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE There is an epidemic of chronic kidney disease in Central America and mortality rates are highest in El Salvador and Nicaragua. This Field Epidemiology Site will recruit 800 residents of the most affected regions of each country including ~400 people with low kidney function at baseline, and ~400 people with high or healthy kidney function at baseline, including men and women. We will follow them for three years to examine kidney function and disease progression over time, and exposure to multiple environmental, social, behavioral and occupational risk factors as part of the Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium.

PI_NAMEs: SCAMMELL, MADELEINE  (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Acceleration;Affect;Age;Agonist;agricultural community;Agricultural Workers;Agriculture;Air Pollution;Alcohols;Asia;Behavior;Behavioral;Biological;Boston;Cause of Death;Central America;Chemicals;Chronic Kidney Failure;Clinical assessments;cohort;Collaborations;Communication;Communities;community research;Complex Mixtures;Consent;Country;Data;Data Coordinating Center;Death Rate;Dehydration;design;Developing Countries;Diabetes Mellitus;Diagnosis;Diet;Disease;Disease Progression;Disease susceptibility;drinking water;Early Diagnosis;early onset;El Salvador;Environment;Epidemic;Epidemiologic Research Design;Epidemiology;Epigenetic Process;Ethics;Etiology;Europe;experience;Exposure to;Family member;Flame Retardants;General Population;Generations;Genetic Predisposition to Disease;Goals;Government;Heat Stress;Heavy Metals;high risk;high risk population;Home;Hot Spot;Hypertension;India;Individual;Infectious Agent;Inherited;Injury to Kidney;International;Kidney;Kidney Diseases;Life Style;male;men;mortality;nephrotoxicity;Nicaragua;Nicaraguan;Nutritional status;Occupational;Older Population;Participant;Pathology;Persons;Pharmaceutical Preparations;Population;Predisposition;Prevalence;Prevention;Procedures;progression risk;Protocols documentation;Public Health;public health intervention;Questionnaires;Recording of previous events;recruit;Renal function;Research;Research Personnel;Risk;Risk Factors;Salvadoran;Sampling;Science;Severity of illness;Site;social;Sri Lanka;Standardization;therapeutic target;Time;Toxic effect;trait;United States National Institutes of Health;Universities;Woman;Work;working men;young man

PROJECT_TITLE: CKDu in Salvadoran and Nicaraguan Agricultural Communities


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Chronic Pain;Clinical Research;Emergency Care;Headaches;Neurosciences;Pain Research;Pediatric;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Headaches in children are common, with a small proportion associated with brain abnormalities (e.g. brain tumors) that require emergent identification. However, a large proportion of children with headaches unnecessarily receive neuroimaging in emergency departments, exposing them to risks, such as an increased lifetime risk of cancer from the radiation in computed tomography scans. Our research will create the first decision-making algorithm that will allow physicians to determine the precise risk of emergent brain abnormalities in children with headaches based on clinical findings, allowing physicians to accurately identify those who require emergent neuroimaging and those who do not.

PI_NAMEs: TSZE, DANIEL SING-KWONG (contact)

PROGRAM_OFFICER_NAME: BROWN, JEREMY

PROJECT_TERMS: 17 year old;Academy;Accident and Emergency department;Acute;Adverse event;Age;American;Applied Research;Brain;brain abnormalities;Brain Neoplasms;cancer risk;Characteristics;Child;Clinical;clinical decision support;Communities;computerized;Craniocerebral Trauma;decision making algorithm;design;Diagnosis;Diagnostic;Emergency Care;Emergency Department Physician;Emergency Medicine;Enrollment;Exposure to;Goals;Headache;Hemorrhage;high risk;improved;Intervention;Intracranial Hemorrhages;Knowledge;lifetime risk;Magnetic Resonance Imaging;Malignant Neoplasms;Methodology;Methods;Migraine;Minor;Modeling;Morbidity - disease rate;Multicenter Trials;neuroimaging;Neurology;Patients;pediatric emergency;Pediatric Neurology;pediatrician;Physical Examination;Physicians;Prevalence;prevent;prospective;Prospective Studies;Radiation;Radiation Dose Unit;radiation risk;Recommendation;Recording of previous events;Research;research study;Respiratory Tract Infections;Risk;Risk Estimate;Risk Factors;risk stratification;Role;Sample Size;Scanning;Secondary to;Sedation procedure;Signs and Symptoms;Sleep;Societies;Statistical Models;Stroke;support tools;Testing;tool;tumor;Uncertainty;X-Ray Computed Tomography

PROJECT_TITLE: Headache Assessment of Children for Emergent Intracranial Abnormalities

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

PROJECT_TERMS: Address;Adoption;Adult;Age;Alabama;arm;Behavioral;Black Populations;Black race;black women;Blood Pressure;Body mass index;Body Weight decreased;burden of chronic illness;burden of illness;Cancer Survivor;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Chronic;Chronic Disease;Clinical;Clinical effectiveness;clinically relevant;Communities;community engaged research;comorbidity;compare effectiveness;comparison intervention;Complex;Continuity of Patient Care;cost;cost effectiveness;Deep South;design;Diabetes Mellitus;Diet;Disease;Disparity;disparity elimination;disparity reduction;Effectiveness;effectiveness outcome;effectiveness/implementation trial;Environment;Environmental Risk Factor;Evidence based intervention;experience;follow-up;glycemic control;Goals;good diet;Harvest;Health;Health behavior;health disparity;health economics;Health Educators;health equity;health equity promotion;Heart Diseases;Heart failure;high risk;Hybrids;Hypertension;implementation intervention;implementation outcomes;implementation science;improved;Individual;Institution;Intake;Intervention;Maintenance;Malignant Neoplasms;Measures;Medical center;men;Mission;Mississippi;Obesity;obesity treatment;Outcome;Overweight;Participant;peer;Physical activity;Population;Prediabetes syndrome;Prevalence;Prevention;primary outcome;Public Health;Race;racial population;Randomized;randomized, clinical trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Resources;Risk Factors;Rural;rural counties;rural dwellers;rural setting;secondary outcome;Services;sex;social culture;socioeconomics;Stroke;Target Populations;Testing;Time;trend;United States;United States Department of Agriculture;Universities;urban setting;Vegetables;waist circumference;Weight;weight loss intervention;White Women;Woman

PROJECT_TITLE: Community-Based Strategies to Reduce Cardiometabolic Disease in the Deep South


NIH_SPENDING_CATS: Brain Disorders;Breast Cancer;Cancer;Neurosciences;Women's Health Research

ORG_CITY: TOLEDO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

PHR: Metastatic breast cancer in the brain is a deadly disease with limited treatment options while other cancers have benefited from the advancement of novel targeted and immune therapeutics. In this study, we seek to investigate a novel strategy to eliminate metastatic breast cancer in the brain by repurposing proton pump inhibitors targeting fatty acid synthase.

PI_NAMEs: ZHANG, JIAN-TING  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Acetyl Coenzyme A;Adriamycin PFS;Binding;Biological Availability;Blood - brain barrier anatomy;blood-brain barrier permeabilization;Brain;Breast Cancer Cell;Breast Cancer Patient;breast cancer survival;cancer cell;cancer subtypes;cancer therapy;Cell Death;Cell Line;Cell Proliferation;Central Nervous System;chemotherapy;Clinical Trials;Computerized Medical Record;Cyclophosphamide;Data;Digestive System Disorders;Disease;DNA Damage;DNA Double Strand Break;DNA Repair;Dose;Doxorubicin;Enzymes;Fatty-acid synthase;FDA approved;Goals;Growth;Human;Immunotherapeutic agent;Immunotherapy;improved;In complete remission;In Vitro;in vivo;Incidence;Inhibition of Cell Proliferation;inhibitor;Ionizing radiation;Laboratory Study;Lipids;Malignant Breast Neoplasm;Malignant Neoplasms;Malonyl Coenzyme A;Metastatic breast cancer;Metastatic malignant neoplasm to brain;meter;Modeling;Molecular;mortality;Neoadjuvant Therapy;Neoplasm Metastasis;neuroprotection;new therapeutic target;Nonhomologous DNA End Joining;novel;novel strategies;Omeprazole;Organ;Outcome;Oxidative Stress;Oxidative Stress Induction;Palmitates;Pathologic;Pharmaceutical Preparations;Phase;phase II trial;Production;Prognosis;prognostic;prospective;Proton Pump Inhibitors;Pump;Recurrence;repaired;Reporting;Research;Retrospective Studies;Serum;standard of care;Supplementation;taxane;temozolomide;Testing;Therapeutic;therapeutic target;three dimensional cell culture;Toxic effect;treatment strategy;triple-negative invasive breast carcinoma;Trust;tumor;Up-Regulation;Xenograft procedure

PROJECT_TITLE: Targeting FASN to eliminate metastatic breast cancer in the brain


ORG_DEPT: PHARMACOLOGY

PHR: Narrative: The goal of this proposal is to develop new technologies to probe protein kinases, which are key regulators of cellular function and important therapeutic targets. These technologies will be applied to study interactions between immune cells and cancer cells in the context of cell-based immunotherapy. Given the importance of protein kinases in a variety of different diseases, including cancer, the technologies and knowledge generated here should pave the road for development of enhanced therapeutic strategies.

PI_NAMEs: WANG, YINGXIAO ;ZHANG, JIN  (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: Address;Behavior;Benchmarking;Biological;Biomedical Engineering;Biosensor;calmodulin-dependent protein kinase II;cancer cell;cancer therapy;Cell Line;Cell model;Cell Physiology;Cells;cellular imaging;Cellular immunotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;Color;comparative;Cyclic AMP-Dependent Protein Kinases;cytokine release syndrome;design;Development;Directed Molecular Evolution;Disease;Engineering;Environment;Enzymes;Event;Evolution;experimental study;Face;Fluorescence Resonance Energy Transfer;fluorophore;frontier;Goals;high resolution imaging;high throughput screening;Image;imaging approach;imaging platform;Immune;immunological synapse formation;Immunotherapy;improved;In Situ;In Vitro;innovative technologies;insight;Knowledge;Life;Link;live cell imaging;Lymphocyte-Specific p56LCK Tyrosine Protein Kinase;Malignant Neoplasms;Mammalian Cell;Mediating;Molecular;Monitor;multiplexed imaging;Mus;Nature;neoplastic cell;new technology;next generation sequencing;Noise;novel;optogenetics;Performance;Phosphotransferases;Play;Post-Translational Protein Processing;Protein Kinase;Proteins;prototype;Reporter;Resolution;Role;sensor;Series;Signal Transduction;spatiotemporal;Specificity;success;System;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Technology;technology platform;Therapeutic;therapeutic target;Time;tool;Toxic effect;tumor;Tumor Escape;Variant;Visualization;ZAP-70 Gene

PROJECT_TITLE: Ultrasensitive kinase biosensors for multiplex imaging of coordinated spatiotemporal signaling in cancer-immune interactions

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE (OVERALL) Childhood cystic kidney diseases (CCKDs), such as Autosomal Recessive Polycystic Kidney Disease (ARPKD), Nephronophthisis (NPHP), and Meckel-Gruber Syndrome (MKS), are devastating disorders causing significant morbidity and mortality. While remarkable progress has been made in identifying genetic factors responsible for cyst pathogenesis, there remain large gaps in our knowledge as well as controversies regarding the function of the affected proteins and which of the associated pathways are at the etiological heart of these diseases. The mission of the UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) is to work with the PKD Consortium and the Central Coordinating Site to develop and share cilia-related bioassay and reporter systems, relevant genetic models and biomaterials, and clinical data for CCKDs that will allow the research base to overcome significant obstacles and drive the translation of basic science discoveries into effective treatments.

PI_NAMEs: YODER, BRADLEY K. (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Animal Model;Autosomal Recessive Polycystic Kidney;base;Basic Science;Biocompatible Materials;Biological Assay;Cell model;Childhood;Cilia;Clinical;Clinical Data;Clinical Trials;Collaborations;Consumption;cost;cost effective;Cyst;Cystic kidney;Cystic Kidney Diseases;Data;data repository;Defect;Development;Disease;Disease Progression;effective therapy;Ensure;Environment;Etiology;Functional disorder;Future;Generations;Genetic;genetic information;Genetic Models;Goals;Grant;Heart Diseases;Human;improved;In Vitro;in vitro Bioassay;in vitro Model;in vivo;Individual;innovation;Institution;International;Kidney Diseases;Knowledge;Laboratories;Localized Disease;longitudinal analysis;Meckel-Gruber syndrome;Medicine;member;Methodology;Mission;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Mutation;National Institute of Diabetes and Digestive and Kidney Diseases;Nephronophthisis;next generation;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Patient Education;Patients;Pharmaceutical Preparations;pre-clinical;Preclinical Testing;prevent;Productivity;programs;protein function;Proteins;Reagent;recruit;Reporter;repository;Reproducibility;Research;Research Activity;Research Personnel;Resource Development;Resources;Scientist;screening;Sensory;serial imaging;Services;Signal Transduction;Site;Standardization;System;Testing;therapeutic development;Time;tool;Toxicology;Training;Translational Research;Translations;treatment strategy;Validation;Vision;Work


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease

PROJECT_TERMS: Acceleration;Animal Model;Basic Science;Benchmarking;Biocompatible Materials;Biological Models;Biometry;Biosensor;Cell model;Childhood;Clinical;Clinical Data;clinical practice;Clinical Trials;Collaborations;Communities;cost effective;Cyst;Cystic kidney;Cystic Kidney Diseases;Data Analyses;Defect;Development;Disease;Disease Progression;Ensure;Experimental Designs;Family;Future;Generations;Genetic;Genetic Materials;Genetic Models;Goals;improved;In Vitro;in vivo;Individual;Informatics;innovation;Interdisciplinary Study;Kidney;Kidney Diseases;Laboratories;Legal;Logistics;longitudinal analysis;material transfer agreement;member;Methodology;Mission;Modeling;multidisciplinary;Mutation;National Institute of Diabetes and Digestive and Kidney Diseases;Outcome;Outcomes Research;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Preclinical Testing;programs;protein function;Proteins;recruit;Reporter;Reproducibility;Reproducibility of Results;Research;Research Activity;Research Personnel;Resource Development;Resource Sharing;Resources;Scientist;serial imaging;Services;Site;Standardization;Structure;System;Testing;therapeutic evaluation;Training and Education;Translational Research;treatment strategy;Validation;Vision;Work

PROJECT_TITLE: UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative There is increasing recognition that place matters when considering cancer outcomes, as a growing body of evidence is showing that structural and environmental factors related to neighborhood disadvantage are associated with cancer incidence, treatment, and mortality. However, there is a need for a more comprehensive assessment of the many different types of neighborhood exposures for cancer incidence for individuals as they change residential locations and accumulate socioeconomic and environmental exposures over the life course. In this proposal, we will consider the cumulative effects of historic neighborhood socioeconomic deprivation, racial segregation, environmental pollutants, and built environment exposures at different times over the lifecourse to better represent the neighborhood exposome for individuals in relation to colorectal, lung, and breast (female) cancer incidence.

PI_NAMEs: JONES, RESA M.;PERERA, ROBERT ANTHONY (contact)

PROGRAM_OFFICER_NAME: DELLAVALLE, CURT TAVIS

PROJECT_TERMS: Area;Automobile Driving;Back;Bayesian Method;Breast;built environment;cancer health disparity;cancer prevention;cancer risk;cancer site;carcinogenicity;case control;Characteristics;Colorectal;Colorectal Cancer;Crime;Data;deprivation;Diagnosis;Disadvantaged;Disparity;disparity reduction;early life exposure;Environmental Exposure;Environmental Pollutants;Environmental Risk Factor;ethnic disparity;Ethnic Origin;evidence base;Exposure to;Female;Female Breast Carcinoma;geographic disparity;Geography;Green space;Health;Incidence;indexing;Individual;Influentials;innovation;interest;Intervention;late life;Life;Life Cycle Stages;Link;Lived experience;Location;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Methods;mortality;Motivation;Nature;neighborhood association;neighborhood disadvantage;Neighborhoods;neoplasm registry;novel;novel strategies;Outcome;Outcomes Research;Pennsylvania;Policies;Policy Developments;pollutant;Population;population based;Prevention Research;Public Health;Race;racial disparity;Racial Segregation;Recording of previous events;Registries;Risk;Risk Assessment;Risk Factors;Role;segregation;sex;Shapes;Societal Factors;socioeconomics;structural determinants;Time;time use;Variant;Virginia;walkability;Work

PROJECT_TITLE: Assessing residential neighborhood exposome exposures and the associations with cancer incidence

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth

PI_NAMEs: KATZMARZYK, PETER TODD (contact)

PROJECT_TERMS: Address;Adult;aged;Alabama;American;Behavioral;Black American;black patient;Black race;Body mass index;Body Weight;Body Weight decreased;Cardiometabolic Disease;cardiometabolic risk;cardiovascular disorder risk;Caring;caucasian American;Chronic;Chronic Disease;Clinic Visits;clinically significant;collaborative care;Communication;Computerized Medical Record;Consolidated Framework for Implementation Research;contextual factors;Continuity of Patient Care;cost effectiveness;Cost Effectiveness Analysis;Deep South;diabetes management;Diabetes Mellitus;Dietary intake;digital medicine;digital technology;Disparity;disparity reduction;effective intervention;effectiveness evaluation;effectiveness testing;eHealth;evidence base;experience;fasting plasma glucose;Focus Groups;glycemic control;Glycosylated hemoglobin A;Goals;Graph;Health;health care service;Health Disparities Research;health disparity;health equity;health related quality of life;Health Services Accessibility;Health Technology;Healthcare Systems;Hybrids;implementation context;implementation intervention;implementation outcomes;implementation science;implementation/effectiveness;Improve Access;improved;Individual;innovation;Integrated Health Care Systems;Intervention;Interview;lifestyle intervention;Louisiana;low health literacy;Low income;Medical;Minority Groups;Mission;Mississippi;Modeling;National Institute on Minority Health and Health Disparities;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;obese patients;Obesity;obesity treatment;Outcome;Patient Care Team;patient health information;patient oriented;Patient Outcomes Assessments;patient portal;Patients;Pharmaceutical Preparations;Physical activity;Population;Prevention;Primary Care;primary care patient;primary care setting;primary outcome;programs;Public Health;Quality of life;Race;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;remote delivery;Research;Research Design;Risk Factors;Science;secondary outcome;service gap;sleep quality;Structure;success;Testing;therapy design;Time;Translations;Transportation;treatment as usual;Underserved Population;United States;Urban Health;video coaching;Videoconferencing;Weight;weight loss intervention;weight loss program

PROJECT_TITLE: Improving Weight Loss and Cardiometabolic Risk in Black Primary Care Patients with Obesity and Diabetes


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Genetics;Kidney Disease;Orphan Drug;Pediatric;Polycystic Kidney Disease;Precision Medicine;Rare Diseases

PI_NAMEs: GUAY-WOODFORD, LISA MARIE (contact)

PROJECT_TERMS: Abbreviations;Acceleration;acronyms;Address;Adult;Affect;American;Americas;Autosomal Dominant Polycystic Kidney;Autosomal Recessive Polycystic Kidney;Award;biobank;Biocompatible Materials;Biological;Breast Fibrocystic Disease;Caregivers;Child;Childhood;Clinical;clinical center;Clinical Data;clinical database;clinical decision-making;Clinical Research;clinically significant;Collaborations;Conceptions;cost effective;Cystic Kidney Diseases;Data;Databases;design;Development;Diagnostic;Disease;disease prognosis;Disease Progression;DNA;effective therapy;Epithelial Cells;evidence base;experience;Foundations;Genetic;genetic information;Genotype;Geography;Goals;Guidelines;Health;Human;human tissue;Individual;individual patient;International;Intervention;Interview;Intuition;Kidney;Kidney Diseases;Knowledge;member;Methodology;Modeling;Molecular;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;novel therapeutics;Observational Study;Pathogenesis;Pathogenicity;Pathway interactions;patient oriented;patient population;Patient Preferences;Patient Recruitments;patient retention;Patients;Phase;predictive marker;prognostic;Prognostic Marker;protein function;Rare Diseases;recruit;Recruitment Activity;renal epithelium;repository;Research;Research Institute;Research Personnel;Resource Development;Resources;retention rate;Scientist;serial imaging;Site;Specimen;Standardization;targeted treatment;therapeutic development;Tissue Banks;tissue resource;Tissues;Translational Research;translational study;Universities;Urine;Voice;Washington;Work

PROJECT_TITLE: UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - Clinical, Translational, and Biorepository Resource


NIH_SPENDING_CATS: Bioengineering;Genetics;Microbiome

ORG_CITY: SEATTLE

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

ORG_STATE: WA

PHR: Project Narrative Even genetically identical bacteria may activate different subsets of genes leading to coexistence of diverse metabolic states and behaviors within a bacterial population. In this work, we will develop and apply high-throughput single-cell transcriptomics approaches to profile heterogeneous phenotypic states within complex bacterial communities such as spatially structured biofilms and reduced complexity microbiota. We will use the results to develop systems-level understanding of the fine-scale phenotypic structure and pave the way toward predicting the emergent properties of biofilms and natural microbiota.

PI_NAMEs: KUCHINA, ANNA  (contact)

PROJECT_TERMS: Bacteria;bacterial community;Behavior;Behavioral;biofilm species;biological adaptation to stress;Biological Assay;biological research;cell behavior;Cells;Communities;Complex;Cues;Data;Development;Ecology;Engineering;Environment;Foundations;Gene Expression;gene regulatory network;Genes;gut microbiota;Horizontal Gene Transfer;Human;Image;Individual;laboratory equipment;Ligation;Maps;Measurement;Measures;member;Metabolic;microbial;Microbial Biofilms;microbial community;Microbiology;microbiome research;microbiota;Nature;network models;Organism;Pathway interactions;Phenotype;Play;Population;Postdoctoral Fellow;programs;Property;Pseudomonas aeruginosa;Reporter;Resolution;response;Role;Sampling;single-cell RNA sequencing;Staphylococcus aureus;Structure;System;Technology;Testing;tool;trait;transcriptomics;Work

PROJECT_TITLE: Single-cell transcriptomics of complex bacterial communities


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: PARANT, JOHN M (contact)

PROJECT_TERMS: Adolescent;Adult;Affect;Alleles;Bardet-Biedl Syndrome;Biological Assay;Biosensor;Categories;Cell Line;Cells;Childhood;Cilia;Communities;conditional knockout;Consultations;CRISPR/Cas technology;Cyclic AMP;Cyst;Cystic kidney;Cystic Kidney Diseases;Data;Defect;Disease;disease model;dominant genetic mutation;Drug Screening;embryonic stem cell;Engineering;Epithelium;experimental study;Fee-for-Service Plans;fighting;Fingerprint;Functional disorder;Generations;Genes;Genetic;Genetic Engineering;Genetic Fingerprintings;Genetic Predisposition to Disease;genetically modified cells;genome editing;Genome Stability;Goals;Human;improved;In Vitro;in vitro Bioassay;in vitro Model;in vivo;in vivo Model;Individual;induced pluripotent stem cell;innovation;Joubert syndrome;Karyotype;Kidney;Kidney Diseases;Knock-out;Laboratories;Learning;Maintenance;Measures;Meckel-Gruber syndrome;member;model development;Modeling;Molecular;Mus;Mutation;Nephronophthisis;Organoids;Outcome;Pathogenesis;Pathway interactions;Patients;personalized medicine;Phase;precision drugs;prevent;protein transport;Proteins;Quality Control;Rattus;Reagent;reagent standardization;repaired;Reporter;Reproducibility;Research;Resource Development;Resources;restoration;screening;Signal Pathway;Site;stable cell line;System;Testing;Therapeutic;tool;Urine;Validation;vector;Visualization

PROJECT_TITLE: UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - In Vitro Bioassay and Model Development Resource


NIH_SPENDING_CATS: Clinical Research;Urologic Diseases;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Our T32 training program proposes to equip MD clinical fellows and PhD post-doctoral fellows with the necessary tools (i.e., didactic training, experiential training, career development, and a trans-disciplinary approach) to perform high-quality clinical outcomes research in female lower urinary tract disorders and to serve as future leaders in this field. Developing this critical mass of highly-trained academic physician- scientists and researchers is important to address the many remaining unanswered questions in this field and to improve the lives of millions of women with bothersome lower urinary tract disorders.

PI_NAMEs: LOWDER, JERRY LANE (contact);SUTCLIFFE, SIOBHAN

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Clinical;Female;Lower urinary tract;Outcomes Research;Research Training;Urologic Diseases

PROJECT_TITLE: Clinical Outcomes Research Training in Female Lower Urinary Tract Disorders

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease;Rare Diseases

PROJECT_TERMS: Acceleration;Address;Affect;Alleles;Animal Disease Models;Animal Model;Animals;Autosomal Dominant Polycystic Kidney;Autosomal Recessive Polycystic Kidney;Bardet-Biedl Syndrome;Basic Science;biobank;Biocompatible Materials;Biological;Biosensor;Categories;Cell model;Cells;Childhood;Cilia;Clinical;Clinical Data;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complement;cost effective;Cyclic AMP;Cyst;Cystic kidney;Cystic Kidney Diseases;Data;data repository;Defect;Development;Disease;disease model;Disease Pathway;effective therapy;effectiveness evaluation;efficacy evaluation;Engineering;FRAP1 gene;Functional disorder;Future;Generations;Genes;Genetic Models;Growth;Home;Human;Human Engineering;improved;In Vitro;in vitro Bioassay;in vivo;in vivo Bioassay;in vivo imaging;Individual;innovation;Institution;intravital imaging;Kidney;Kidney Diseases;Macrophage;Measures;Meckel-Gruber syndrome;member;Missense Mutation;Mission;model development;Modeling;Morphology;multidisciplinary;Mus;mutant;Mutation;National Institute of Diabetes and Digestive and Kidney Diseases;Nephronophthisis;novel;novel therapeutics;Organism;Outcome;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Pilot Projects;Polycystic Kidney Diseases;pre-clinical;protein function;protein purification;Proteins;Rattus;Reagent;Reporter;Reproducibility;Research;Research Activity;Research Personnel;Resource Development;Resources;response;Sampling;screening;Sensory;serial imaging;Services;Signal Pathway;Signal Transduction;Site;Standardization;STAT3 gene;Syndrome;System;Tail;Testing;Therapeutic;therapeutic development;therapeutic evaluation;Training;Translational Research;treatment strategy;Uncertainty;Vision;Work

PROJECT_TITLE: UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - In Vivo Bioassay and Model Development Resource


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE  The goal of this project is to test whether an intervention to bolster the local food economy (increase fruit and  vegetable production) and develop programs that respond to the critical link between nutrition and development  of chronic illness can increase fruit and vegetable consumption, improve minority health, and reduce health  disparities. Community-centered efforts that build vital local food economies represent a major innovation that  integrates nutrition into the healthcare system and social safety net to reduce disease, lessen disparities, and  save billions of dollars in health care expenditures annually.

PI_NAMEs: ECONOMOS, CHRISTINA D (contact);MILLER, JULIAN D.

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Address;Adult;African American;Agriculture;Area;Behavioral;Biological;Black race;Blood Pressure;Body mass index;cardiometabolic risk;Chronic Disease;college;Communities;community engaged intervention;community engaged research;community engagement;community engagement process;community organizations;community partners;community-centered;comparison control;Consumption;County;design;Development;Diabetes Mellitus;diabetes risk;Disadvantaged;Disease;Disparity;disparity reduction;Economic Models;Economics;Environment;Equity;experience;Farm;farmer;Food;food desert;food insecurity;Food Policy;fruits and vegetables;Generations;Glycosylated hemoglobin A;Goals;Growth;Health;health care service utilization;health disparity;health disparity populations;Health Expenditures;Healthcare Systems;improve minority health;improved;improved outcome;Individual;innovation;Intervention;Link;Marketing;Measures;Medicare/Medicaid;Medicine;member;men;Minority Groups;minority health disparity;Mississippi;mobile health clinic;Modeling;National Institute on Minority Health and Health Disparities;novel;nutrition;Obesity;Outcome;Outcome Measure;Participant;Physical environment;policy recommendation;Poverty;Production;programs;Randomized;Randomized, Controlled Trials;Recording of previous events;Reduce health disparities;Research;response;Risk Factors;Rural Minority;safety net;social;social culture;Social Justice;Soil;Sunflowers;Testing;Universities;Vertebral column;Washington;Woman;Work

PROJECT_TITLE: A multilevel community engaged intervention to build a sustainable and equitable food economy with food is medicine offerings in the Mississippi Delta to improve minority health and reduce disparities


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Cost Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth

PI_NAMEs: MEHTA, TAPAN S (contact)

PROJECT_TERMS: Address;Adult;Affect;Age;Alabama;Black American;black patient;Black race;Blood Pressure;Cardiometabolic Disease;cardiometabolism;Cardiorenal syndrome;Cardiovascular Diseases;cardiovascular risk factor;Cause of Death;Chronic;Chronic Disease;Chronic Kidney Failure;Clinical;Communication;Communities;community partners;comorbidity;Consolidated Framework for Implementation Research;contextual factors;Continuity of Patient Care;cost effective;cost utility analysis;Deep South;design;diabetes control;diabetes education;diabetes management;dietary;digital health;disorder risk;Disparity;disparity reduction;Economics;Education;effectiveness evaluation;Enrollment;experimental study;Food;food insecurity;glucose monitor;glycemic control;Glycosylated hemoglobin A;Goals;Health;health care availability;health disparity;health equity;health equity promotion;Health Food;Health Services Accessibility;Health system;Healthcare Systems;Hemoglobin;Household;Hypoglycemia;implementation framework;implementation intervention;implementation outcomes;implementation process;improved;Individual;industry partner;Inequity;Insurance;Intervention;Investments;Louisiana;Low income;Mental Health;Methods;Mission;Mississippi;multiphase optimization strategy;Non-Insulin-Dependent Diabetes Mellitus;Outcome;outcome disparities;Participant;Patient Care Team;Patients;Persons;Politics;Poverty;Prevention;primary outcome;programs;Public Health;Public Policy;racial health disparity;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;relative cost;remote delivery;remote monitoring;remote patient monitoring;Resources;Social Conditions;social health determinants;social vulnerability;Transportation;trend;Weight;Work

PROJECT_TITLE: Food Delivery, Remote Monitoring, and coaching-Enhanced Education for Optimized Diabetes Management (FREEDOM)


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Kidney Disease;Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed Field Epidemiology Site (FES) located in the Chorotega region in Costa Rica will recruit, enroll and follow participants for the CURE Consortium and perform comprehensive assessments of risk factors, environmental exposures and health contexts, allowing to identify one or more causes for CKDu that could be targeted for prevention, intervention or policy.

PI_NAMEs: ARIAS-HIDALGO, MARIELA ;ENGEL, LAWRENCE STUART;FRANCESCHINI, NORA  (contact)

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Affect;Age Distribution;agricultural community;Agricultural Workers;Agriculture;Biological;Biological Markers;Case/Control Studies;Cessation of life;Chemical Exposure;Chemicals;Child;Chronic Kidney Failure;Clinical;Clinical assessments;Collaborations;combustion product;Communities;Community Health;community research;Costa Rica;County;Data;Data Coordinating Center;dietary;Dietary Factors;Disease;drinking water;Enrollment;Environmental and Occupational Exposure;Environmental Exposure;Environmental Health;Epidemic;Epidemiology;epidemiology study;Ethical Issues;Etiology;Exposure to;Family;Family Study;field study;Foundations;Frequencies;Funding;Future;Genetic Predisposition to Disease;Glomerular Filtration Rate;Goals;Government Officials;Health;Health Personnel;Healthcare;Heat Stress;Human;Individual;Injury to Kidney;Intervention;Kidney;kidney biopsy;Knowledge;Language;Liberia;Life Style;male;Measurement;Measures;Metals;Methods;Natural History;Non-Steroidal Anti-Inflammatory Agents;North Carolina;Occupational;Occupational Exposure;Occupational Health;Participant;Patient Self-Report;Pesticides;Pharmaceutical Preparations;Phenotype;Physicians;Policies;predictive marker;premature;Prevalence;Prevention;prospective;Prospective Studies;Province;Public Health;recruit;Research;Research Design;Research Personnel;Resources;response;Risk Assessment;Risk Factors;safety and feasibility;Sampling;Science;Seasons;Serum;Sex Distribution;Silicones;Site;social;Solid;Universities;urinary;Urine;Vulnerable Populations;Woman;Work;Workplace;wristband

PROJECT_TITLE: The Chorotega CKDu Epidemiology Field Study