NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Hematology;Human Genome;Prevention;Rare Diseases

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: PROJECT NARRATIVE  Heparin-induced thrombocyoptenia (HIT) is an unpredictable, life-threatening, immune-mediated adverse reaction to heparin treatment. The proposed research is relevant to public health because it has the potential to provide insight into HIT pathogenesis and significantly contribute to clinical translation of HIT biomarkers into preventive and early diagnostic strategies. Thus, the proposed research is relevant to the part of the NIH mission that pertains to reducing the burden of adverse drug reactions in cardiovascular disease.

PI_NAMEs: KARNES, JASON HANSEN (contact)

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: ABO blood group system;Acute;adverse drug reaction;Adverse reactions;Affect;Alleles;Antibodies;Antibody Formation;biobank;Biological;Biological Assay;Biological Markers;Blood;blood group;Blood typing procedure;Cardiovascular Diseases;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;clinical practice;clinical translation;cohort;Computerized Medical Record;Coupled;Data;Death Rate;deep sequencing;Detection;diagnostic strategy;direct application;DNA;Ethnic Origin;experimental study;Family;Genes;Genetic;Genetic Determinism;Genetic Drift;genome wide association study;genome-wide analysis;genomic variation;Genomics;Genotype;Guide RNA;Helper-Inducer T-Lymphocyte;Heparin;heparin-induced thrombocytopenia;HLA Antigens;Hospitalization;Immune;Immunogenetics;Immunogenomics;immunopathology;Incidence;Incubated;Individual;innovation;insight;Knowledge;Life;Maps;Measures;Mediating;Membrane Proteins;Mission;Modeling;Molecular;Odds Ratio;Outcome;overexpression;Pathogenesis;Pathogenicity;Pathology;Patients;PF4 Gene;Phase;Population;Population Heterogeneity;Prevention;Prevention strategy;Preventive;programs;Proliferating;Public Health;Publishing;racial diversity;Reaction;Research;Resolution;Risk;Role;Sample Size;Sampling;Staphylococcal Enterotoxin B;T cell receptor repertoire sequencing;T-Cell Activation Pathway;T-Cell Proliferation;T-Cell Receptor;Testing;Th2 Cells;Thromboembolism;transcriptome;transcriptome sequencing;United States National Institutes of Health;Variant;Work;γδ T cells

PROJECT_TITLE: ABO and Immunogenetic Variation in the Pathogenesis of Heparin-Induced Thrombocytopenia

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Rare Diseases;Telehealth

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project Narrative Extreme behaviors and communication challenges contribute to functional impairments across nearly all aspects of daily life for individuals with intellectual and developmental disabilities (IDD), exacerbating preexisting health inequalities. This study seeks to adapt a telehealth parent-implemented challenging behavior intervention for delivery through medical hubs serving complex, severely affected genetic syndromes associated with IDD. The tailoring and scaling of evidence-based behavioral interventions for syndromic IDDs provides a compelling model to provide timely and accessible care for these complex conditions during periods of service disruption, such as the COVID-19 pandemic, as well as for families living in traditionally underserved and/or under resourced communities.

PI_NAMEs: VALLURIPALLI SOORYA, LATHA  (contact);WAINER, ALLISON LEIGH

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Address;Adult;Affect;Age;Angelman Syndrome;applied behavior analysis;Behavior;Behavior Therapy;Behavioral;behavioral health;behavioral health intervention;behavioral phenotyping;behavioral response;Blinded;care systems;Caregiver support;Caregivers;Caring;Child;Child Behavior;Child Rearing;Clinical;Clinical effectiveness;Cognitive;Communication;Communication difficulty;Communities;community intervention;Complex;COVID-19 impact;COVID-19 pandemic;Data;design;Disparity;effective intervention;effectiveness evaluation;effectiveness-implementation RCT;effectiveness/implementation study;Environment;Equipment and supply inventories;evidence base;Exclusion;experience;Family;Functional impairment;Genetic;Goals;health inequalities;Health Services;Health Services Accessibility;Healthcare;Home;Hybrids;Impairment;implementation science;impression;improved;Individual;individuals with autism spectrum disorder;innovation;Intellectual functioning disability;Intervention;intervention delivery;Interview;Life;life span;Measures;Medical;Mental Health;Methods;minimally verbal;Modeling;Modification;Natural History;Neurobiology;Outcome;pandemic disease;Parents;Participant;Patients;person centered;Phelan-McDermid syndrome;Phenotype;Population;programs;Provider;psychosocial;Publishing;Questionnaires;Randomized;Randomized, Controlled Trials;reinforced behavior;Reporting;Research;Resources;screening;Services;severe intellectual disability;social;Standardization;standardize measure;Subgroup;Surveys;Syndrome;telehealth;Testing;treatment as usual;Tuberous Sclerosis;virtual;Vulnerable Populations;Work

PROJECT_TITLE: Promoting Prosocial Behavior in Syndromic Intellectual and Developmental Disabilities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-M(54)R]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision

ORG_CITY: BOSTON

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

ORG_STATE: MA

PHR: Project Narrative Angiogenesis, the growth of new blood vessels, is a destructive component of a number of ocular diseases, including wet age-related macular degeneration. We have shown that endomucin, a glycoprotein located at the surface of endothelial cells, the cells that comprise blood vessels, can regulate angiogenesis. We propose studies to understand the role of endomucin in both normal and abnormal pathologic angiogenesis; to determine at the molecular level how endomucin functions to regulate new blood vessel growth; and, to take advantage of endomucin’s function to develop a novel inhibitor of pathologic neovascularization.

PI_NAMEs: D'AMORE, PATRICIA ANN (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Adult;Age related macular degeneration;angiogenesis;Antigens;bevacizumab;Binding;Binding Proteins;Biochemical;Biological;Blood capillaries;Blood Vessels;Breeding;cadherin 5;Capillary Endothelial Cell;cell motility;Cells;Characteristics;Choroidal Neovascularization;Chronic;Combined Modality Therapy;Data;Development;Dimerization;Endocytosis;Endothelial Cells;endothelial-specific sialomucin;Endothelium;Extracellular Domain;Eye diseases;genetic approach;Glycocalyx;Glycoproteins;glycosylation;Growth;Human;Immune Sera;Immunoprecipitation;In Vitro;in vivo;inhibitor;insight;Investigation;KDR gene;knock-down;Knock-out;Lasers;Ligand Binding;Ligands;LoxP-flanked allele;Mass Spectrum Analysis;Mediating;Methods;migration;Modeling;Molecular;Monoclonal Antibodies;mouse model;Mus;Mutagenesis;mutant;N-Glycosylation Site;neovascularization;new growth;novel;Ocular Pathology;Pathologic;Pathologic Neovascularization;Pathology;Patients;Permeability;prevent;Process;Proliferating;Reagent;Receptor Activation;Receptor Signaling;Regulation;Reporting;Retina;Role;Route;Signal Induction;Signal Pathway;Signal Transduction;Site;Small Interfering RNA;Structure;Surface;Tamoxifen;Testing;Tube;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;vascular factor;Vascular Permeabilities;Vascularization;VEGF Trap;Work

PROJECT_TITLE: Investigation of endomucin as a novel regulator of angiogenesis

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cancer Genomics;Chronic Obstructive Pulmonary Disease;Clinical Research;Genetics;Human Genome;Lung;Lung Cancer;Physical Activity;Prevention;Social Determinants of Health

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Through the study of adults at the age when lung health reaches its peak in young adulthood, we will identify exposures and biomarkers associated with susceptibility and resilience to future lung disease. This work will allow for an investigation into the pathobiologic mechanisms important to the onset and progression of lung disease and the development of strategies to detect the earliest manifestations of deviations from ideal respiratory health. The ALA Lung Health Cohort will generate knowledge which ultimately leads to strategies for the interception of chronic lung disease at its earliest stages.

PI_NAMEs: CARNETHON, MERCEDES RENEE;KALHAN, RAVI  (contact);SUGAR, ELIZABETH ANN;WASHKO, GEORGE R

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Adult;Age;age acceleration;age related decline;aged;Air Pollution;airway epithelium;American Lung Association;Attention;Bioinformatics;Biological;Biological Markers;Biological Specimen Banks;Blood;blood-based biomarker;Cardiovascular system;Cells;chest computed tomography;Chest imaging;Chronic;Chronic Disease;Chronic lung disease;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;Clinical;clinical care;Clinical Research;cohort;Communities;Data;Data Coordinating Center;Development;Electronic cigarette;emerging adult;Environmental Epidemiology;Evaluation;Evolution;Exposure to;Fibrinogen;Funding;Future;Gene Expression;Geography;Goals;Health behavior;Health Promotion;Image;Impairment;Individual;Infrastructure;Inhalation Exposure;injured airway;Injury;insight;Intention;Intercept;Investigation;Knowledge;Life Cycle Stages;life span;Longitudinal Studies;Lung;Lung Diseases;lung health;lung injury;Marijuana;Matrilysin;Measurement;Measures;metropolitan;modifiable risk;multidisciplinary;Nasal Epithelium;Nose;novel;Occupational;Outcome;Participant;Patient Outcomes Assessments;Patient Self-Report;Pattern;Phenotype;Physical activity;Physical Fitness;Physicians;Physiological;Predisposition;prevent;Prevention approach;Prevention strategy;Primary Prevention;Proteins;Publishing;pulmonary function;Pulmonary Surfactant-Associated Protein D;receptor for advanced glycation endproducts;Recording of previous events;recruit;Research Personnel;resilience;respiratory;Respiratory Disease;respiratory health;Respiratory Signs and Symptoms;response;Risk;Risk Factors;Scanning;Social Behavior;soluble RAGE;Testing;transcriptome;transcriptomics;Translating;Work;X-Ray Computed Tomography;young adult

PROJECT_TITLE: The American Lung Association (ALA) Lung Health Cohort


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SYRACUSE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Glaucoma, a leading cause of irreversible blindness worldwide, is projected to affect 100 million individuals by the year 2040. It is defined as an age-associated optic neuropathy characterized by retinal ganglion cell death; a barrier to treating glaucoma is that the mechanisms underlying cell susceptibility in this disease are very poorly understood. This proposal investigates mechanisms by which astrocytes, the primary support cells for retinal ganglion cells, sense their mechanical environment in glaucoma; the data obtained from these studies will help to develop novel therapies to treat this difficult disease.

PI_NAMEs: GANAPATHY, PREETHI  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: 3-Dimensional;Affect;age related;Astrocytes;Atomic Force Microscopy;Biochemical;Biocompatible Materials;Biological Models;Biology;Biomechanics;Bioreactors;Blindness;career development;Cell Death;cell injury;cell type;Cells;Communities;Consensus;crosslink;Data;Dedications;design;Development;Development Plans;Disease;Drug Targeting;Encapsulated;Environment;experience;experimental study;Extracellular Matrix;Foundations;Functional disorder;ganglion cell;Glaucoma;Gliosis;Goals;Hydrogels;Image;in vivo;Individual;inhibitor;Injections;innovation;Intraperitoneal Injections;Ion Channel;knock-down;Lead;mechanical stimulus;Mechanical Stress;Mechanics;Mediating;Mentors;Microspheres;Modeling;modifiable risk;Mus;new therapeutic target;novel;novel therapeutics;Optic Disk;optic nerve disorder;Physiologic Intraocular Pressure;Piezo 1 ion channel;Piezo ion channels;Positioning Attribute;Predisposition;prevent;programs;Property;Proteins;Research;research and development;Research Personnel;response;retinal damage;Retinal Ganglion Cells;Risk Factors;sensor;Site;skills;Small Interfering RNA;Solid;stressor;success;Support System;Supporting Cell;System;Techniques;Testing;Time;Tissue Engineering;Tissues;tool;Translating;Universities;viscoelasticity;Vision;Vision research

PROJECT_TITLE: Investigating mechanosensation in the glaucomatous optic nerve head


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: No effective treatment exists to reverse the severe bone loss that occurs in persons with chronic spinal cord injury (SCI), which predisposes them to low-impact fractures. The proposed work will test a medication, romosozumab, in individuals with chronic SCI that has been highly successful in the treatment of osteoporosis. Treatment with romosozumab will be followed by a second medication, denosumab, to prevent loss of bone that was gained with romosozumab. Restoration of the skeleton below the level of spinal lesion would be anticipated to reduce the morbidity associated with fractures and permit safe and more confident participation in activities of daily living, better integration into the community, as well as activity-based rehabilitation strategies, such as body weight supported treadmill training and exoskeletal-assisted walking, which may be denied to persons with chronic SCI due to low bone mass. Thus, the proposed study will test a promising new pharmacological approach to improve bone health, which is important to general wellbeing and independence.

PI_NAMEs: CARDOZO, CHRISTOPHER P (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Aftercare;Age;American;Anabolic Agents;Animals;antagonist;Antibodies;Architecture;Biochemical Markers;Biological Markers;Body Weight;bone;Bone Density;bone health;bone loss;bone mass;Bone Resorption;Bone structure;bone turnover;career;Caring;Chronic;Clinical;Clinical Trials Cooperative Group;clinically relevant;Collagen Type I;Communities;Control Groups;Controlled Clinical Trials;cortical bone;density;Depressed mood;Deterioration;Distal;Double-Blind Method;Dual-Energy X-Ray Absorptiometry;Dual-Photon Absorptiometries;effective therapy;Eligibility Determination;Employment;exoskeleton;experience;Femur;Fracture;fragility fracture;functional electrical stimulation;group intervention;Hip region structure;human monoclonal antibodies;Impairment;improved;Individual;Injury;Intervention;Lead;Length;Lesion;Lower Extremity;male;Manuals;Measurement;Measures;Mechanics;Metaphysis;Minerals;Modality;Morbidity - disease rate;Motor;N-terminal;novel strategies;Osteocalcin;Osteogenesis;Osteoporosis;Outcome;Outcome Measure;Paralysed;Participant;Peripheral;Personal Satisfaction;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Placebo Control;placebo group;Placebos;Population;Postmenopausal Osteoporosis;powered exoskeleton;preclinical study;prevent;primary endpoint;Principal Investigator;Qualifying;Quality of life;Randomized;Rattus;recruit;rehabilitation strategy;Rehabilitation therapy;Research Personnel;restoration;secondary endpoint;Secure;Site;skeletal;Skeleton;Spinal;Spinal cord injury;Spinal Cord Lesions;Spinal Cord transection injury;Spinal Injuries;standard of care;substantia spongiosa;Testing;tibia;Time;Training;treadmill training;Veterans;Walking;walking rehabilitation;Weight-Bearing state;women subjects;women's treatment;Work;X-Ray Computed Tomography

PROJECT_TITLE: Romosozumab to Improve Bone Mineral Density and Architecture in Chronic SCI

STUDY_SECTION: RRDA

STUDY_SECTION_NAME: Spinal Cord Injury/Disorders & Neuropathic Pain[RRDA]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: PROVIDENCE

ORG_NAME: ENVIRONMENTAL MANAGEMENT, RHODE ISLAND DEPT OF

ORG_STATE: RI

PHR: PROJECT NARRATIVE The Rhode Island Department of environmental Management – Division of Agriculture project: Rhode Island Produce Safety Program’s Plan to Enhance On-Farm Food Safety and Implement the Produce Safety Rule under Path C (Regulatory Band 8 and Education & Inventory Band 8) will implement a produce safety regulatory program that will promote and enhance on-farm food safety in the growing, harvesting, packing and holding of produce on Rhode Island farms. This project will be a partnership between the state of Rhode Island, FDA and other state agencies will result in increased compliance with the Produce Safety Rule, with the goal of promoting public health and integration into a national Integrated Food Safety System (IFSS).

PI_NAMEs: FRASER RAMIREZ, ANANDA  (contact)

PROGRAM_OFFICER_NAME: FREDRICK, JEANETTE

PROJECT_TITLE: Path C Rhode Island Produce Safety Program’s Plan to Enhance On-Farm Food Safety and Implement the Produce Safety Rule under Path C


ORG_CITY: CHARLESTON

ORG_NAME: WEST VIRGINIA STATE DEPT OF AGRICULTURE

ORG_STATE: WV

PHR: West Virginia Department of Agriculture Cooperative Agreement Program to Implement a National Produce Safety Program PAR-21-174 Narrative To minimize illnesses and deaths related to the consumption of contaminated produce, the West Virginia Department of Agriculture (WVDA) will continue to implement and enhance state compliance with the Food and Drug Administration’s (FDA) Food Safety Modernization Act (FSMA). The proposed project activities will provide education, outreach and technical assistance; annual state farm inventory; inspection, compliance and enforcement for covered farms; and response to produce related events.

PI_NAMEs: O'DELL, ANDREA  (contact)

PROJECT_TITLE: Path B Implementation of a State Program in West Virginia to Enhance Produce Safety in Compliance with the FSMA Produce Safety Rule Using Program


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE (Public Health Relevance Statement)  Cancer is a leading cause of death in the United States and throughout the world with minorities suffering a disproportionate burden of the cancer threat with disparate outcomes for many cancer types. Given the tremendous medical advances over the past 50 years since the National Cancer Act of 1971, the United States population's life expectancy has dramatically increased, but because the incidence of most cancers increases with age, cancers have become a profound challenge to the United States health care system. To meet these challenges, dedicated cancer research at the SKCCC and elsewhere has generated fundamental insights into the molecular mechanisms that cause human cancers to arise, progress and threaten life, which create new opportunities to improve screening, detection, diagnosis, prevention and treatment.

PI_NAMEs: NELSON, WILLIAM GEORGE (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: African American;Age;Aging;anti-cancer research;biomedical scientist;Bone Marrow Transplantation;Cancer Burden;cancer care;cancer cell;Cancer Center Support Grant;Cancer Control;cancer genetics;cancer health disparity;cancer imaging;cancer immunotherapy;Cancer Patient;cancer prevention;cancer therapy;cancer type;career development;Catchment Area;Cause of Death;Chemicals;Clinical Research;Clinical Trials;Communities;Comprehensive Cancer Center;Dedications;Defect;Detection;Diagnosis;Enrollment;Epidemiology;Epigenetic Process;Equipment and supply inventories;Functional Imaging;Funding;Future;Genetic;Genome;Goals;Health Professional;Healthcare Systems;Heart Diseases;Hematologic Neoplasms;Human;Human Characteristics;Immunotherapy;improved;Incidence;innovation;insight;Intervention;Intervention Studies;Intervention Trial;Invaded;Knowledge;Life;Life Expectancy;Life Style;Malignant Neoplasms;Maryland;Medical;member;Minority;Minority Participation;Molecular;Molecular Genetics;molecular imaging;mortality;multidisciplinary;National Cancer Institute;NCI Center for Cancer Research;Neoplasm Metastasis;new technology;Oncology;Outcome;outcome disparities;Patient Care;Patients;Peer Review;Peer Review Grants;Population;Population Group;precision oncology;Prevention;Productivity;programs;public health relevance;Publications;Research;Research Personnel;Research Training;Resource Sharing;Science;Scientist;screening;Screening for cancer;Services;Specimen;structural biology;Therapeutic Studies;tool;Training and Education;Translating;trend;tumor immunology;tumorigenesis;United States;Universities;Work

PROJECT_TITLE: Regional Oncology Research Center

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: WOLLETT, ROSALIE  (contact)

PROJECT_TERMS: Acceleration;Achievement;anti-cancer research;Applications Grants;Award;Budgets;Businesses;Cancer Center;Cancer Center Support Grant;cancer immunotherapy;cancer research center director;career development;Catchment Area;Clinical Data;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Colon Carcinoma;Communication;Community Developments;community engagement;Community Outreach;Comprehensive Cancer Center;data management;Development;Doctor of Medicine;Doctor of Philosophy;Education;Educational Activities;Electronics;Ensure;Evaluation;experience;Faculty;Fostering;Funding;Future;Gifts;Goals;Grant;Growth;Health;high standard;Infrastructure;innovation;Institution;Intervention;Investments;Leadership;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant Neoplasms;Maryland;meetings;member;Minority;Mission;Monitor;NCI Center for Cancer Research;Oncology;Outcome;Outpatients;patient navigator;patient outreach;Peer Review;Policies;Population;Process;programs;recruit;Reporting;Research;Research Activity;Research Personnel;Research Support;Resource Sharing;Resources;Schools;Science;Services;social media;Strategic Planning;success;symposium;System;Training and Education;Translational Research;Vision;web site

PROJECT_TITLE: Administrative Core


PI_NAMEs: ARMANIOS, MARY Y (contact)

PROJECT_TERMS: Address;Advocate;anti-cancer research;anti-racism;Area;Basic Science;Biomedical Engineering;Budgets;cancer education;cancer epidemiology;Cancer Pain Management;career;Catchment Area;childcare allowance;Clinical;clinical investigation;community collaboration;community engagement;Community Outreach;Comprehensive Cancer Center;dashboard;Data;Data Science;Dedications;Development;Discipline;Discipline of Nursing;Diverse Workforce;Doctor of Philosophy;Education;Education Projects;Educational Curriculum;Educational workshop;Environment;Epidemiology;equity, diversity, and inclusion;Faculty;Feedback;Fellowship;Funding;Future;genetic counselor;Goals;graduate medical education;graduate school;Grant;Health;Health Professional;high school;high school program;High School Student;Historically Black Colleges and Universities;Immunology;improved;innovation;Institution;Leadership;lecturer;Link;Malignant Neoplasms;Maryland;matriculation;Medical;Medical Oncologist;medical schools;medical specialties;Medical Students;Medicine;member;Mentored Clinical Scientist Development Program;Mentorship;Minority;Molecular Biology;Molecular Medicine;multidisciplinary;Nanotechnology;National Cancer Institute;Nurses;Oncology;Oncology Nurse;oncology program;Operative Surgical Procedures;Outcome;pandemic disease;pandemic impact;pandemic response;Pathway interactions;Pediatric Oncologist;Peer Review;Pharmacists;Pharmacy facility;Physicians;Policies;Population Sciences;post-doctoral training;Postbaccalaureate;Postdoctoral Fellow;programs;prospective;Public Health;Radiation;recruit;Research;Research Training;Resources;sabbatical;Schools;Science;science teacher;Scientist;social determinants;Social Workers;Strategic Planning;Structure;Students;success;Surgical Oncologist;symposium;synergism;Talents;Technology;Training;Training Activity;Training and Education;Training Programs;Translational Research;Tribes;undergraduate student;Underrepresented Populations;Underrepresented Students;United States;United States National Institutes of Health;Universities;University resources;Woman;Writing

PROJECT_TITLE: Cancer Research Training and Education Coordination


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: ORTHOPEDICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Rotator cuff tears, which are the most prevalent shoulder diseases, cause enormous soft tissue pain on patients and impair their normal mobility during their work and sports activities. Primary cilia, cellular antennae protruding from mammalian cell surfaces, have been demonstrated to transduce and coordinate mechanical and biochemical signals in muscle, bone, cartilage, and growth plate. The proposed project will determine how primary cilia regulate development and healing of the tendon-to-bone attachment (tendon enthesis), leading to the development of new therapeutic strategies.

PI_NAMEs: FANG, FEI  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Ablation;Acute;Adult;Affect;Age;Architecture;Biochemical;Biological Assay;Biology;biomechanical test;Biomechanics;bone;bone fracture repair;Cartilage;Cell surface;Cell Transplantation;Cells;Chondrocytes;Chondrogenesis;Cicatrix;Cilia;Clinical;cost;Data;Deterioration;Development;disability;Disease;Environment;Epiphysial cartilage;Erinaceidae;Event;experience;Failure;Fibrocartilages;General Population;Genetic Transcription;healing;Hypertrophy;Immunohistochemistry;Impairment;improved;In Situ Hybridization;in vivo;injured;Injury;Knockout Mice;Knowledge;Label;Length;Maintenance;Mammalian Cell;mechanical force;mechanical load;mechanical properties;mechanical signal;Mechanical Stimulation;Mechanics;mechanotransduction;Mediating;Medical;mineralization;Modeling;Molecular;mouse model;Mus;Muscle;muscle regeneration;Natural regeneration;Neonatal;novel;novel therapeutic intervention;Older Population;Operative Surgical Procedures;Organelles;Outcome;Pain;Pathogenesis;Pathology;Pathway interactions;Patients;pharmacologic;Pilot Projects;Population;postnatal;Process;programs;Protocols documentation;Regenerative capacity;Regulation;repaired;Reporter;Reporting;response;Role;Rotator Cuff;rotator cuff tear;Shoulder;Shoulder Pain;Signal Transduction;single cell ATAC-seq;single molecule;single-cell RNA sequencing;smoothened signaling pathway;soft tissue;Sports;stem cell function;stem cell population;stem cells;stemness;Stimulus;Tendon structure;Testing;Therapeutic;therapeutically effective;Tissues;transcriptomics;Transgenic Mice;United States;Work

PROJECT_TITLE: Mechanisms of Primary Cilia Regulating Tendon Enthesis Development and Regeneration

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Cancer;Genetics;Prevention

PI_NAMEs: AZAD, NILOFER S. (contact)

PROJECT_TERMS: Appointment;Biological Markers;Brain;Breast;Cancer Biology;Cancer Center Support Grant;cancer genetics;cancer initiation;Cellular biology;clinical biomarkers;Clinical Cancer Center;Clinical Investigator;Clinical Trials;Collaborations;Colon;Comprehensive Cancer Center;Data;design;Development;Diagnostic;Direct Costs;Discipline;Disease;Doctor of Medicine;Doctor of Philosophy;Epigenetic Process;Funding;Genetic;Goals;Guidelines;Head and neck structure;Human;Individual;Intervention;Investigation;investigator-initiated trial;Journals;K-Series Research Career Programs;Laboratories;Leadership;Lung;Malignant Neoplasms;member;Molecular;Molecular Abnormality;Molecular Biology;Monitor;National Cancer Institute;novel therapeutics;Oncology;organizational structure;Ovarian;Pancreas;peer;Peer Review;personalized cancer care;pre-clinical;preclinical study;prognostic;programs;Publications;Research;Research Peer Review;Resource Sharing;Schools;Scientist;Screening for cancer;Structure;Therapeutic;Translating;translational goal;tumor initiation;tumor progression;United States National Institutes of Health;virtual;Work

PROJECT_TITLE: Cancer Genetics and Epigenetics


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Mental Health;Neurosciences;Opioids;Pediatric;Social Determinants of Health;Violence Research

ORG_CITY: NEW HAVEN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE We propose that abnormal dysregulation of the brain beta-endorphin signaling pathway plays a central role linking insecure attachment with key behavioral and cognitive hallmarks of childhood maltreatment. We plan to test this novel idea using a mouse model of complex trauma combined with new tools to record and manipulate specific populations of neurons in the mouse brain. At its conclusion, this work will illuminate novel targets that can reduce the devastating psychiatric and medical consequences of childhood maltreatment.

PI_NAMEs: DIETRICH, MARCELO  (contact);KAFFMAN, ARIE

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Abbreviations;Ablation;Adolescence;Adolescent;Animal Model;Attention;Beds;Behavior;Behavioral;beta-Endorphin;Brain;Buffers;Caring;Child Abuse and Neglect;Childhood;Cognitive;Complex;Crying;Cues;Detection;Distress;early life adversity;early life stress;Early-life trauma;Electrophysiology (science);emotion dysregulation;Endorphin Receptors;Etiology;Exposure to;Fiber;Genetic;Human;Hypothalamic structure;Impairment;Impulsivity;in vivo;Individual;Infant;insight;Life;Link;maternal separation;Medical;Methods;Modeling;Mothers;mouse model;mu opioid receptors;Multiple Trauma;Mus;Neurons;nonhuman primate;novel;offspring;Opioid;Opioid agonist;pediatric trauma;Peptides;Photometry;Play;Population;Pro-Opiomelanocortin;Process;programs;pup;receptor;Receptor Signaling;receptor-mediated signaling;response;Risk;Role;Safety;Secure;Signal Pathway;Slice;social;Social Behavior;Socialization;Source;stress reduction;Substance Use Disorder;System;Testing;tool;Trauma;Ultrasonics;vocalization;Work

PROJECT_TITLE: Dysregulation of the opioid system in early life adversity

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Cancer;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: JONES, RICHARD J (contact)

PROJECT_TERMS: AIDS Malignancy Consortium;AIDS related cancer;Allogeneic Bone Marrow Transplantation;American College of Radiology Imaging Network;Appointment;Area;Back;bench-to-bedside translation;Biology;Blood;Bone Marrow;Bone marrow failure;Bone Marrow Transplantation;cancer stem cell;Categories;Center Core Grants;Clinic;Clinical;clinical translation;Clinical Trials;Clinical Trials Network;clinically relevant;Collaborations;Comprehensive Cancer Center;Cyclophosphamide;Cytochrome P450;Development;Diagnosis;Disease;Doctor of Medicine;Doctor of Philosophy;Dose;Dysmyelopoietic Syndromes;Early Therapeutic-Clinical Trials Network;Eastern Cooperative Oncology Group;Ensure;Enzymes;Epigenetic Process;epigenome;Faculty;FLT3 gene;FLT3 inhibitor;Funding;Genetic;Goals;graft vs host disease;Grant;Hematologic Neoplasms;Hematopoiesis;improved;insight;Institution;International;Investigation;Journals;K-Series Research Career Programs;Laboratories;Leadership;leukemia;Maintenance Therapy;Malignant - descriptor;Malignant lymphoid neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;member;Molecular Target;Monitor;Multiple Myeloma;National Cancer Institute;neoplastic;novel;novel therapeutics;Oncology;Outcome;Pathway interactions;Peer Review;Play;post-transplant;prognostic;Program Research Project Grants;programs;Prophylactic treatment;Publications;Research;research clinical testing;Research Personnel;Resources;Role;Schools;Seminal;Sickle Cell Anemia;success;Therapeutic;Translating;translation assay;translational diagnostics;Translational Research;Translations;tumor DNA;Work

PROJECT_TITLE: Hematologic Malignancies and Bone Marrow Transplantation


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Using the gold-standard HIV infection mouse model available at the time and microPET-neuroimaging, we discovered that osteopontin/secreted phosphoprotein-1 (OPN/SPP1) is a potent sensor of neuroinflammation in the brain. The conservation of OPN/SPP1 as a sensor/regulator of CNS homeostasis and abundant expression in microglia during development and under injury to the brain, strongly suggests that it plays a key central mechanistic role in neuroprotective pathways that modulate neuroinflammation. This proposal will apply a combinatorial approach to identify and study how OPN/SPP1 performs its functions which we hypothesize occur via specific ligand-receptor interactions initiated by microglia and propagated by specific neurons in the striatum.

PI_NAMEs: BROWN, AMANDA MARIA (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Adult;Affective;Aging;antiretroviral therapy;Autopsy;Basal Ganglia;Behavior;Biochemical;Brain;brain tissue;Buffers;Cells;Cerebellum;Cerebral Ventricles;chemokine;Chemotactic Factors;Chimera organism;Chronic;chronic infection;Cognition;Cognitive;Color;combinatorial;Corpus striatum structure;cytokine;Detection;Development;Experimental Models;Flow Cytometry;Genetic Transcription;Goals;HIV;HIV Infections;Homeostasis;Human;humanized mouse;Immune;In Vitro;in vivo;Incidence;Infection;Inflammation;Inflammatory;Injury;insight;Integrins;Investigation;ITGB3 gene;knock-down;Ligands;Liver;Lung;Macrophage;Magnetic Resonance Imaging;Mammals;Measures;Microglia;microPET;Modification;Molecular;monocyte;mouse model;Mus;Myeloid Cells;Nerve Degeneration;neuroAIDS;neuroimaging;neuroinflammation;Neurologic;Neurons;neuroprotection;nigrostriatal dopaminergic pathway;novel;Organ;osteopontin;Pathway interactions;Pattern;Peripheral;Persons;Play;Prevalence;Primary Cell Cultures;Proteins;receptor;receptor expression;Receptor Signaling;Recovery;Reporting;Residencies;Resolution;response;RNA;RNA Splicing;Role;Sampling;sensor;sex;Signal Transduction;SIV;Specificity;Spleen;Structure of choroid plexus;System;Systemic infection;Testing;Therapeutic;Time;Tissues;tool;trafficking;Tyrosine 3-Monooxygenase;Variant;Virus Replication

PROJECT_TITLE: HIV-OPN/SPP1Triad II: Molecular Pathways Regulating Neuronal-Glial Inflammation in the Brain

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Cancer;Immunization;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Rare Diseases;Vaccine Related

PI_NAMEs: PARDOLL, DREW M. (contact)

PROJECT_TERMS: Animal Model;anti-PD-1;Antineoplastic Agents;Cancer Center Support Grant;cancer immunotherapy;cancer therapy;cancer type;Cellular Immunology;chemotherapy;Clinical;clinical material;Clinical Research;Collaborations;Colorectal Cancer;companion diagnostics;Comprehensive Cancer Center;Dedications;design;Development;Direct Costs;Disease;DNA Modification Methylases;Doctor of Medicine;Doctor of Philosophy;fitness;Funding;Genetic Markers;Glutamine;Guidelines;Histone Deacetylase Inhibitor;Immune checkpoint inhibitor;Immune response;Immune Targeting;Immunology;immunoregulation;Immunotherapy;immunotherapy clinical trials;Industry;inhibitor;innovation;insight;Institution;International;Intervention;investigator-initiated trial;Journals;K-Series Research Career Programs;Laboratories;Laboratory Research;Lead;Leadership;Macrophage;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Melanoma;member;Memory;Metabolic;Microsatellite Instability;Mismatch Repair Deficiency;Mission;Molecular Immunology;mutant;Myeloid-derived suppressor cells;National Cancer Institute;Neoadjuvant Therapy;neoplastic cell;novel;Oncology;Pathway interactions;peer;Peer Review;Peptide Vaccines;personalized immunotherapy;Pharmaceutical Preparations;Phase;predictive marker;Prodrugs;programmed cell death ligand 1;programs;Publications;Research;research clinical testing;Research Peer Review;Research Personnel;Resistance;Seminal;standard of care;T-Lymphocyte;Therapeutic Agents;therapeutic evaluation;Translating;Translations;Tumor Immunity;tumor immunology;Tumor-Infiltrating Lymphocytes;United States National Institutes of Health;Vaccination;Work

PROJECT_TITLE: Cancer Immunology


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Machine Learning and Artificial Intelligence;Precision Medicine

PI_NAMEs: BHUJWALLA, ZAVER M. (contact)

PROJECT_TERMS: Appointment;Artificial Intelligence;Biological Markers;biomarker evaluation;Cancer Cachexia;Cancer Center;cancer genetics;Chemistry;clinical translation;Collaborations;Comprehensive Cancer Center;Data;Detection;Development;Diagnosis;Disease;drug development;Early identification;Epigenetic Process;Extracellular Matrix;Fibroblasts;Functional Imaging;Funding;Goals;Hypoxia;Image;Image Analysis;image reconstruction;imaging agent;imaging probe;imaging program;Immune;interest;Invaded;Journals;Malignant Neoplasms;member;Metabolism;Molecular Biology;molecular imaging;Monitor;multidimensional data;multimodality;National Cancer Institute;Neoplasm Metastasis;novel;Oncology;Peer Review;precision medicine;Prognosis;programs;Publications;Research;research clinical testing;response;risk prediction;Role;Schools;Selection for Treatments;Stromal Cells;Subgroup;theranostics;Therapeutic;Therapy Evaluation;translational applications;tumor;tumor immunology;tumor microenvironment;tumor progression;tumor-immune system interactions

PROJECT_TITLE: Cancer Molecular and Functional Imaging


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: Nashville

ORG_DEPT: PSYCHOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: NARRATIVE This proposal seeks to renew funding for a successful and long-running program of training in vision and eye research at Vanderbilt University, built on its core elements of course work (featuring our long-running course The Vision System), world-class seminars, intense laboratory research, and, finally, training in writing and scientific presentation. During this last funding period, our trainees enjoyed high levels of productivity and placement in jobs across industry and tenure-track faculty positions. Here we outline how we plan to continue to improve our training of the next generation of vision scientists during the next 5 years.

PI_NAMEs: WOODMAN, GEOFFREY F (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Grant;Training;Vision research

PROJECT_TITLE: Training Grant in Vision Research


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Colorectal Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Lung;Lung Cancer;Pancreatic Cancer;Prevention;Rare Diseases;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Women's Health Research

PI_NAMEs: KLEIN, ALISON P (contact)

PROJECT_TERMS: Address;anti-cancer research;Appointment;Area;Bacteria;Blood;Cancer Biology;Cancer Burden;Cancer Center;Cancer Control;Cancer Detection;cancer health disparity;Cancer Patient;cancer prevention;cancer risk;Cancer Survivor;Cancer Survivorship;career development;Catchment Area;Clinical;Collaborations;Colon;Colorectal Cancer;community engagement;Community Outreach;Comprehensive Cancer Center;Conduct Clinical Trials;curative treatments;Cyst;detection test;Development;Disparity;disparity reduction;Doctor of Philosophy;Early Diagnosis;Effectiveness;Equity;Evaluation;financial toxicity;Funding;Future;Genetic Predisposition to Disease;Genetic Risk;genetic variant;Genomics;geographic disparity;Goals;Grant;Head and Neck Cancer;Health;healthy weight;high risk population;HIV;HPV positive;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;improved;improved outcome;Inflammatory;Infrastructure;innovation;Institution;Intercept;International;Intervention;Intervention Studies;Journals;Knowledge;Laboratories;Learning;Lesion;lifestyle factors;Link;Malignant Breast Neoplasm;malignant mouth neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;member;Mentors;Microbial Biofilms;Mission;Molecular;multidisciplinary;National Cancer Institute;novel;Obesity;Observational Study;older adult;Oncology;Pancreatic Cyst;Peer Review;Periodontal Diseases;Persons;Policies;Population;population based;Population Heterogeneity;Population Intervention;premalignant;prevent;Prevention;Prevention strategy;Preventive;Primary Prevention;Process;programs;Public Health;Publications;Race;recruit;Recurrence;Reproduction spores;Research;Research Methodology;Research Priority;Resources;Risk Factors;risk stratification;Safety;Schools;Science;Screening for cancer;Secondary Prevention;Secure;Seminal;Smoking;social;social health determinants;success;Survivors;Target Populations;Technology;telecoaching;tertiary prevention;Testing;therapeutic evaluation;therapeutic HPV vaccine;tool;Training and Education;Translating;translational cancer research;Translations;tumor immunology;vaccine acceptance;Woman;Work

PROJECT_TITLE: Cancer Prevention and Control Program


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Foodborne Illness;Immunization;Infectious Diseases;Nutrition;Prevention;Vaccine Related

ORG_CITY: STONY BROOK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE The project is relevant to public health because understanding how priming and the vitamin A metabolite retinoic acid promotes the induction of intestinal tissue-resident memory CD8 T cells will engender better vaccines that target gut pathogens. Vitamin A deficiency is associated with poor immune responses and reduced vaccine efficacy to oral vaccines. As such, understanding the relationship between retinoic acid signals during T cell priming, induction of intestinal tissue-resident memory CD8 T cells, and clinical outcomes of infection and immunization is relevant to the NIH mission.

PI_NAMEs: SHERIDAN, BRIAN S (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Agonist;antagonist;Attenuated;CCR9 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Clinical;Data;Dendritic Cells;Development;Diet;dietary;Disease;Distal;draining lymph node;Event;experimental study;foodborne;foodborne infection;gastrointestinal;Gastrointestinal Neoplasms;Generations;Goals;human pathogen;Immune response;Immunity;Immunization;improved;In Situ;Individual;Infection;Inflammatory Bowel Diseases;innovation;Integrins;intestinal epithelium;Intestines;Invaded;Knockout Mice;Knowledge;Licensing;Listeria monocytogenes;Lymphoid Tissue;Maintenance;Malnutrition;Mediating;Memory;mesenteric lymph node;migration;Mission;Molecular;mouse model;Mus;novel;oral vaccine;Outcome;pathogen;Pathogenicity;Pathway interactions;Patient-Focused Outcomes;precursor cell;Public Health;Research;Residencies;Retinoic Acid Receptor;Signal Transduction;Site;Spleen;T cell differentiation;T cell response;T memory cell;T-Cell Activation;T-Cell Development;T-Lymphocyte;targeted treatment;Testing;therapy development;tissue resident memory T cell;Tissues;Tretinoin;tumor;United States National Institutes of Health;vaccination strategy;Vaccine Design;vaccine efficacy;vaccine immunogenicity;vaccine platform;Vaccines;Vitamin A;Vitamin A Deficiency

PROJECT_TITLE: Impact of priming on the generation of intestinal tissue-resident memory T cells

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


PI_NAMEs: BERGER, JAMES M. (contact)

PROJECT_TERMS: Acceleration;anti-cancer;Antibodies;Antineoplastic Agents;Area;Arts;Basic Science;Binding;Biochemical;Biological;Biological Assay;Biological Products;Biology;cancer cell;Cancer Center;Cell Survival;Cells;Cellular biology;Chemicals;Chromatin Remodeling Factor;Clinical;clinical development;Clinical Research;clinical translation;Clinical Trials;Collaborations;Comprehensive Cancer Center;Coupled;Credentialing;Data;design;Development;DNA;drug candidate;Drug Delivery Systems;Drug Kinetics;Encapsulated;Engineering;Enzymes;experimental study;Faculty;Fostering;Foundations;Funding;Genetic;genetic information;Goals;Human;Immune;Immune response;immunoengineering;immunomodulatory therapies;immunoregulation;Immunotherapy;improved;in vivo;leukemia;Libraries;Malignant Neoplasms;medical schools;member;Methods;Molecular;Molecular Biology;Molecular Target;Monitor;nanoparticle;National Cancer Institute;new therapeutic target;novel;novel anticancer drug;novel lead compound;novel strategies;nucleic acid delivery;Nucleic Acids;Oncology;Pathway interactions;Peer Review;Permeability;Pharmaceutical Preparations;Polymers;Post-Translational Protein Processing;pre-clinical;preclinical development;Preclinical Testing;preservation;Prodrugs;programs;prospective;Protein Microchips;protein protein interaction;Public Health Schools;Publications;pyrophosphatase;Research;research clinical testing;Research Personnel;Scholarship;Schools;Science;screening;Site;small molecule;small molecule libraries;Specificity;structural biology;success;synergism;System;targeted delivery;Technology;Therapeutic;Therapeutic Agents;Therapeutic Intervention;Therapeutic Studies;therapeutic target;tool;Translating;translational approach;translational pipeline;Translational Research;transmission process;tumor microenvironment;Universities;Validation

PROJECT_TITLE: Cancer Chemical and Structural Biology


PI_NAMEs: EWALD, ANDREW JOSEF (contact)

PROJECT_TERMS: 3-Dimensional;Address;Adhesions;Aging;Animal Model;anti-cancer treatment;Area;Automobile Driving;Biology;Biomedical Engineering;Biophysics;Cancer Biology;cancer cell;Cancer Patient;cancer recurrence;Catchment Area;cell behavior;cell motility;Cell Physiology;Cells;Clinic;Clinical;Clinical Trials;Collaborations;Colon Carcinoma;Complex;Comprehensive Cancer Center;Cytometry;design;Disease;Disparity;Distant Metastasis;Doctor of Medicine;Doctor of Philosophy;Drug Targeting;Early Diagnosis;Engineering;Epithelium;Faculty;Funding;Gene Expression;Genes;Genetic Screening;Genetically Engineered Mouse;Genomics;Goals;Grant;Head and neck structure;Image;Immune;Individual;insight;Interdisciplinary Study;Invaded;Journals;Lead;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;Mass Spectrum Analysis;Mechanics;medical schools;Melanoma;member;men;Metastatic Prostate Cancer;migration;Modeling;Molecular;molecular imaging;mortality;mouse model;multiple omics;National Cancer Institute;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;novel;Oncology;Organ;Organism;Organoids;Outcome;patient derived xenograft model;Patient-Focused Outcomes;Patients;peer;Peer Review;physical science;Physiological;Process;Productivity;programs;Prostate;Public Health Schools;Publications;Radiation;Radiation Dose Unit;real-time images;reconstruction;Recurrence;Recurrent disease;Regulation;Research;Research Personnel;Resistance;Resource Sharing;Schools;Scientist;Services;single cell sequencing;Site;skills;Skin;Stress;success;System;Techniques;technology development;Therapeutic;three dimensional cell culture;Tissues;tool;Toxic effect;Training;Translating;translational physician;tumor;tumor microenvironment;tumor progression;United States National Institutes of Health;Universities;Upper aerodigestive tract cancer;Work

PROJECT_TITLE: Cancer Invasion and Metastasis


ADMINISTERING_IC: DA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Substance Misuse

ORG_CITY: EL PASO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

ORG_STATE: TX

PHR: 8. PROJECT NARRATIVE This study proposes to promote sustained viral suppression by building an optimized intervention for people who inject drugs and are living with HIV on the U.S.-Mexico Border. Interventions have shown success in achieving shorter-term viral suppression outcomes among people who inject drugs, but we propose to identify the intervention components that derive the greatest benefits and impact on viral suppression with the goal to promote long-term viral suppression. The intervention is being implemented in a real-world setting and with real-world constraints in place to facilitate the greatest possibility of scalability.

PI_NAMEs: LECHUGA, JULIA  (contact);SAUCEDA, JOHN ANDREW

PROGRAM_OFFICER_NAME: MANDLER, RAUL N

PROJECT_TERMS: Achievement;antiretroviral therapy;Area;Attention;Baseline Surveys;Behavioral;biobehavior;Black Box;career;Caring;Characteristics;Cities;Communities;Control Groups;cost;Counseling;Data;Decision Making;Dedications;depressive symptoms;design;Engineering;experimental study;Explosion;Face;follow up assessment;follow-up;Goals;Health;HIV;Hot Spot;Illicit Drugs;Injecting drug user;injection drug use;Injections;innovation;Intervention;intervention delivery;intervention program;Knowledge;Latinx;Latinx population;Life;Mediating;Mediation;Mediator;medication compliance;medication-assisted treatment;meetings;Mental Depression;Methods;Mexico;Modernization;multiphase optimization strategy;Opioid;Outcome;Participant;patient navigation;peer support;Performance;primary outcome;product development;programs;psychosocial;Qualifying;Randomized;Research;Resources;response;scale up;Science;service organization;Services;Site;Social Work;Spanish;success;System;Test Result;Testing;Texas;therapy adherence;Underserved Population;United States National Institutes of Health;uptake;Viral;Viral Load result;Visit;Work

PROJECT_TITLE: Optimizing a bio-behavioral intervention to promote viral suppression among HIV+ people who inject drugs on the U.S.-Mexico border

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: BRAWLEY, OTIS W. (contact)

PROJECT_TERMS: 10 year old;Acceleration;Address;Adoption;Advocacy;Advocate;Age;Ambulatory Care;Area;Authorization documentation;Baltimore;Basic Science;Black race;Cancer Burden;Cancer Center;Cancer Control;Cancer Death Rates;cancer diagnosis;cancer health disparity;Cancer Patient;cancer prevention;cancer research center director;cancer risk;care delivery;care outcomes;Caring;Catchment Area;Cigarette;Cities;Clinical;Clinical Research;college;colon cancer screening;Communication;Communities;community advisory board;community center;community engagement;community involvement;Community Outreach;Comprehensive Cancer Center;Consult;County;Databases;Death Rate;demographics;design;Diagnosis;diet and exercise;Disparity;Disparity population;disparity reduction;distinguished professor;Doctor of Medicine;Doctor of Philosophy;Epidemiologist;Epidemiology;Ethnic Origin;evidence base;Evidence based intervention;Extramural Activities;Family;Fostering;Funding;Goals;Government;Government Officials;Health;Health behavior;health care delivery;Health education;health inequalities;Hospitals;Human Papilloma Virus Vaccination;Improve Access;Incidence;Income;Infrastructure;Intervention;Intervention Trial;Investments;Leadership;learning community;Malignant Neoplasms;Managed Care;Maryland;Medicaid;Medical Faculty;Medicine;meetings;member;Monitor;mortality;NCI Center for Cancer Research;Newly Diagnosed;Oncology;outreach;Participant;Philosophy;Policies;Policy Developments;Policy Maker;Population;Population Characteristics;Population Research;Population Sciences;Poverty;Process;programs;public education;Quality of Care;racial diversity;Recommendation;recruit;Research;Research Personnel;Research Support;Resources;Rural;Rural Community;screening;Second Opinions;Site;social influence;socioeconomics;Strategic Planning;suburb;suburban communities;System;Taxes;Time;tobacco control;Tobacco Industry;Underserved Population;Urban Community;Vaccination;Vulnerable Populations;Washington;Work

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Vaccine Related

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Chronic viral infections affect millions of people worldwide and post a major public health challenge. This proposal aims to identify the molecular and cellular mechanisms required for long-term antiviral CD8 T-cell immunity and efficacy of immunotherapy against chronic viral infection. The results from this study will unveil novel targets that can be harnessed to induce durable control of chronic viral infection in patients.

PI_NAMEs: WU, TUOQI  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Affect;Anti-CD40;anti-viral efficacy;Anti-viral Response;Antigen Targeting;antiviral immunity;BACH2 gene;BCL6 gene;Biological Assay;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cell Shape;Cells;Cellular Metabolic Process;Chronic;chronic infection;cytokine;Data;Dendritic Cells;Development;Endowment;Energy Metabolism;Environment;Epigenetic Process;exhaust;exhaustion;Exhibits;Flow Cytometry;Foundations;Genetic Transcription;global health;Goals;Hepatitis B Virus;Hepatitis C virus;Heterogeneity;HIV;HIV Infections;Human;Immune response;Immunity;Immunotherapy;improved;Interferon Type I;Intervention;Knockout Mice;Lymphocytic choriomeningitis virus;Lymphoid Tissue;Malignant Neoplasms;Mediating;Metabolic;metabolic fitness;Metabolic Pathway;Metabolism;Mitochondria;Modeling;Molecular;mouse genetics;mouse model;Mus;Mutant Strains Mice;novel;Pathway interactions;Patients;PD-1 blockade;Persons;Poly I-C;Population;Preventative vaccination;Primates;programs;Public Health;Publications;Publishing;quantitative imaging;receptor;Reporter;Respiration;response;Role;self-renewal;SIV;stem;Subunit Vaccines;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;tool;transcription factor;Treatment Efficacy;Vaccine Therapy;Vaccines;Viral;Viral Cancer;Viremia;Virus;Virus Diseases;XCR1 gene

PROJECT_TITLE: Program stem-like CD8 T cells to enhance antiviral immunity against chronic viral infection


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: NELSON, WILLIAM GEORGE (contact)

PROJECT_TERMS: Area;Award;Cancer Center Support Grant;Center for Translational Science Activities;Clinical Trials;Comprehensive Cancer Center;Development;Direct Costs;Extramural Activities;Faculty;flexibility;Fostering;Funding;Grant;innovation;Investments;K-Series Research Career Programs;Laboratory Research;Legal patent;Malignant Neoplasms;member;National Cancer Institute;NCI Center for Cancer Research;Oncology;Peer Review;programs;Publications;Publishing;recruit;Research;Research Personnel;Resource Sharing;Services;Source;Strategic Planning;Translational Research;Underrepresented Minority;United States National Institutes of Health;Woman

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

PROJECT_TERMS: Accountability;Address;Advocacy;anti-cancer research;Area;Back;biomedical scientist;cancer cell;Cancer Center;Cancer Center Support Grant;cancer epidemiology;cancer health disparity;cancer imaging;cancer research center director;career;career development;Catchment Area;Cellular biology;Clinical;Clinical Cancer Center;Clinical Research;Clinical Services;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Consultations;Data;Decision Making;Detection;Diagnosis;Education;effectiveness research;Engineering;Ensure;Environment;equity, diversity, and inclusion;Evaluation;expectation;Faculty;Fostering;Funding;Future;Goals;Growth and Development function;Health Professional;improved;Individual;innovation;International;Investments;Laboratories;Laboratory Research;Leadership;Medical;member;Mission;Molecular Biology;Monitor;NCI Center for Cancer Research;Oncology;Operations Research;Patient advocacy;Performance;Persons;Play;Policies;Population;Population Heterogeneity;Population Sciences;Positioning Attribute;Prevention;Productivity;programs;Protocols documentation;Reporting;Research;Research Training;Resource Allocation;Resource Sharing;Resources;response;Role;Safety;Science;Scientific Evaluation;Scientist;Screening for cancer;Secure;Strategic Planning;Structure;success;Suggestion;Surgical Oncology;Training;Training and Education;Translations;tumor immunology;Vision

PROJECT_TITLE: Leadership, Planning and Evaluation


ORG_CITY: BISMARCK

ORG_NAME: NORTH DAKOTA STATE DEPART OF AGRICULTURE

ORG_STATE: ND

PHR: North Dakota CAP Narrative The grant funds will continue to be used to assess the needs in North Dakota (ND), develop educational materials, provide outreach, verify the ND farm inventory, and develop a multi-year strategy to address the needs of ND farmers that are affected by the FSMA Produce Safety Rule.

PI_NAMEs: NIETERS, JENNA UNITED STATES (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, ANDREA

PROJECT_TITLE: North Dakota Cooperative Agreement to Enhance Produce Safety in Preparation of Implementation of FDA's Rule: Standards for the Growing, Harvesting, Packing, & Holding of Produce for Human Consumption


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety

PI_NAMEs: CARDUCCI, MICHAEL A (contact)

PROJECT_TERMS: Address;African American population;Aging;Cancer Center;cancer clinical trial;Cancer Patient;cancer therapy;care seeking;Catchment Area;Child;Clinical Cancer Center;Clinical Data;clinical investigation;Clinical Investigator;Clinical Management;Clinical Protocols;Clinical Research;clinical training;Clinical Trials;Clinical Trials Data Monitoring Committees;Communities;community engagement;Community Health Education;Community Outreach;Comprehensive Cancer Center;Conduct Clinical Trials;Continuing Education;Data;Data Collection;data management;data quality;data quality/integrity;Data Reporting;Disease;disparity reduction;diversity and inclusion;Education;Ensure;Environment;Faculty;Fostering;health equity;high risk;Hospitals;improved;Individual;Infrastructure;innovation;Institution;Institutional Policy;Intervention;Intervention Trial;Investigational Drugs;Investigational New Drug Application;Laws;Lead;Leadership;life span;Malignant Neoplasms;Maryland;Medical center;member;Minority;Mission;Modality;Monitor;multi-site trial;multidisciplinary;National Cancer Institute;NCI Center for Cancer Research;Nursing Faculty;Nursing Research;Office of Administrative Management;Oncology;operation;patient oriented;patient safety;Patients;Pediatric Hospitals;Peer Review;Procedures;Process;programs;Protocols documentation;Randomized;recruit;Registries;repository;Research;Research Personnel;Resource Sharing;Resources;Safety;Series;Services;Site;suburb;Support Groups;System;Therapeutic Trials;timeline;Training;Translational Research;trial comparing;Underserved Population;Woman;Work

PROJECT_TITLE: Clinical Protocol and Data Management


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative U2R Research Training Program Project Title: “Research Training in Data Science for Health in Rwanda” MPIs: VG Davila-Roman; PRO Payne; D Tumusiime; C Twizere; W Ndifon This partnership between Washington University in St. Louis, University of Rwanda (UR) and African Institute of Mathematical Sciences (AIMS) in Kigali, Rwanda proposes to develop a comprehensive research training program in Data Science. A high prevalence of communicable and non-communicable diseases in Rwanda forecasts a perfect public health storm. We will recruit masters, doctorate, postdoctoral and junior faculty trainees to establish a sustainable program for training, research, mentoring and career development to position UR and AIMS as national and regional African leaders and a global hub for Data Science for Health in Rwanda.

PI_NAMEs: DAVILA-ROMAN, VICTOR G. (contact);NDIFON, WILFRED ;PAYNE, PHILIP R.O.;TUMUSIIME, DAVID ;TWIZERE, CELESTIN

PROGRAM_OFFICER_NAME: POVLICH, LAURA

PROJECT_TERMS: Address;Africa;African;Applications Grants;Area;Bioinformatics;career;career development;Chronic;Collaborations;Communicable Diseases;Competence;computer science;Coupled;COVID-19;data hub;data management;Data Science;Data Scientist;design;Development;Diabetes Mellitus;Disease;Dissemination and Implementation;Doctor of Philosophy;Educational Curriculum;Environmental Exposure;Epidemic;Epidemiology;Faculty;Feedback;Fostering;Funding;Grant;health science research;Health Sciences;Healthcare;Heart Diseases;High Prevalence;HIV;Hypertension;improved;Individual;Informatics;innovation;Institution;institutional capacity;Leadership;Malaria;Manuscripts;mathematical sciences;Mathematics;Mentors;Modeling;multidisciplinary;next generation;Outcome;Positioning Attribute;Postdoctoral Fellow;Program Evaluation;Program Sustainability;programs;Public Health;Research;Research Project Grants;Research Training;Rwanda;Science;Signal Recognition Particle;skills training;statistics;Structure;Training;Training Programs;Universities;Washington;webinar;Writing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(70)]


PROJECT_TERMS: Address;Area;authority;Awareness;Behavioral Sciences;Biometry;Cancer Center;cancer clinical trial;cancer research center director;Catchment Area;Charge;Clinical;Clinical Data;Clinical Protocols;Clinical Research;Clinical Research Protocols;clinical trial protocol;Committee Members;Communication;Comprehensive Cancer Center;Data;Dedications;design;Disease;Ensure;experience;Faculty;Feedback;Fostering;Funding Agency;Goals;human subject;improved;Individual;Institution;Institutional Review Boards;Intervention Trial;Leadership;life span;Malignant Neoplasms;meetings;Minor;Minority;Modality;Modification;Monitor;multidisciplinary;Office Management;Oncology;Pathology;Patient advocacy;patient population;Pattern;Peer Review;Policies;pre-clinical;Process;programs;protocol development;Protocols documentation;Research;Research Personnel;Resource Sharing;Resources;Review Committee;Safety;Site;Support System;System;Time;timeline;Triage;Woman;Work;Writing

PROJECT_TITLE: Protocol Review and Monitoring System


PI_NAMEs: WONG, JOHN W (contact)

PROJECT_TERMS: Animals;Biological;Biological Models;Bioluminescence;Cancer Biology;Cancer Center;Cancer Model;Cell Culture Techniques;Cell model;clinical translation;clinically relevant;Complement;Comprehensive Cancer Center;cone-beam computed tomography;Development;DNA Damage;dosimetry;Equipment;Experimental Designs;experimental study;Fees;Fluorescence;Gene Modified;Goals;Human;image guided;imaging capabilities;immune modulating agents;Immunology;Immunotherapy;improved;instrument;Ionizing radiation;irradiation;Laboratory Animals;Maintenance;member;Modeling;Molecular;mouse model;NCI Center for Cancer Research;new technology;Oncology;operation;Optics;pre-clinical;pre-clinical research;preclinical study;programs;Radiation;Radiation therapy;Radiobiology;repaired;Reporting;Research;Resource Sharing;Resources;response;Roentgen Rays;Safety;Schedule;Services;soft tissue;Source;System;Technology;technology development;technology platform;Testing;therapeutic evaluation;tomography;Training;Translational Research;treatment planning;treatment strategy;tumor;Tumor Immunity;tumor microenvironment;Vendor;Xenograft procedure

PROJECT_TITLE: Experimental Irradiators


PI_NAMEs: LEMAS, VICTOR M (contact)

PROJECT_TERMS: Acceleration;antigen-specific T cells;Biological Assay;Biology;Biopsy;Blood;Cancer Patient;cancer therapy;cell analyzer;Cell Separation;cell type;Cells;Cellular Assay;Clinical;Collaborations;Color;combinatorial;Companions;Complex;Comprehensive Cancer Center;Consultations;cytokine;Cytometry;Data Analyses;Data Set;Development;Doctor of Medicine;Doctor of Philosophy;Educational Status;Ensure;Experimental Designs;experimental study;flexibility;Flow Cytometry;Flow Cytometry Shared Resource;Frequencies;Generations;Genomics Shared Resource;Human;Image;Immune;Immune checkpoint inhibitor;Immune response;Immunology;Immunotherapy;improved;innovation;Institution;instrument;instrumentation;Leadership;Lymphoid;Malignant neoplasm of lung;Malignant Neoplasms;Medical;member;metabolic abnormality assessment;Methodology;Methods;Molecular;Monitor;Mutation;neoantigens;new technology;novel;Oncology;Patients;Phenotype;Physics;Population;pre-clinical;preclinical study;Procedures;programs;Publications;Reagent;Regimen;Reporting;Research;Research Personnel;Resource Sharing;Resources;response;sample collection;Scientist;screening;Series;Services;single-cell RNA sequencing;Soft tissue sarcoma;Sorting;Specimen;Specimen Handling;Suspensions;T cell receptor repertoire sequencing;T cell response;T-Cell Receptor;T-Lymphocyte;Technical Expertise;Techniques;Technology;technology development;Time;tool;Training;translational scientist;tumor;tumor microenvironment;Tumor-Infiltrating Lymphocytes;vaccine trial;Work

PROJECT_TITLE: Flow Cytometry and Technology Development


NIH_SPENDING_CATS: Anorexia;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Serious Mental Illness

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE It is unknown why many individuals with severe psychiatric disorders repeatedly and inflexibly engage in behaviors that are harmful. For instance, in anorexia nervosa, rigid pursuit of weight loss leads to serious physical and psychiatric outcomes, and even death; in obsessive-compulsive disorder rigid compulsive behaviors (e.g., excessive checking, cleaning) lead to severe impairment. In order to ultimately design more effective treatments, this project addresses the critical need to identify distinct biological and behavioral decision-making processes that keep people with anorexia nervosa and other related psychiatric disorders (e.g., obsessive-compulsive disorder) stuck pursuing harmful goals.

PI_NAMEs: HAYNOS, ANN FRANCES (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Anorexia Nervosa;Area;Automobile Driving;Behavior;Behavior Control;Behavior Disorders;Behavioral;biobehavior;Biological;Body mass index;Body Weight decreased;Brain;Budgets;Categories;Cessation of life;Characteristics;Clinical;Cognitive;cognitive control;cohort;comparison group;Compulsive Behavior;computational neuroscience;Computer Models;Conflict (Psychology);Corpus striatum structure;cost;Dangerousness;Data;Death Rate;Decision Making;design;Diffusion;Disease;Dorsal;Eating Disorders;Ecological momentary assessment;Economics;effective therapy;executive function;follow-up;Food;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;habit learning;Habits;Hyperactivity;Impairment;Individual;insight;Internet;Intervention;Interview;Lead;Link;Mental disorders;Metric System;Modeling;Morbidity - disease rate;mortality risk;neural;neuroeconomics;Neurophysiology - biologic function;Neurosciences;novel;Obsessive-Compulsive Disorder;Outcome;Parietal Lobe;Participant;Pathologic;Pathway interactions;Pattern;Persons;Phenotype;predict clinical outcome;Prefrontal Cortex;Process;prototype;Psychiatric therapeutic procedure;psychologic;Reaction Time;recruit;Research;response;reward circuitry;Rewards;Role;Science;severe psychiatric disorder;Specificity;standard care;Symptoms;System;Testing;Time;Training;translational neuroscience;Weight maintenance regimen

PROJECT_TITLE: Rule-Based Decision-Making: A Novel Neuroeconomic Mechanism of Anorexia Nervosa

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: YEGNASUBRAMANIAN, SRINIVASAN  (contact)

PROJECT_TERMS: Acceleration;Address;Adopted;Agreement;analysis pipeline;analytical tool;Applications Grants;archived data;Area;Basic Science;Bioinformatics;Biometry;cancer genome;cancer genomics;Clinical;Common Good;Comprehensive Cancer Center;Computational Biology;Computing Methodologies;computing resources;Consultations;coping;cost;Curiosities;Custom;Data;Data Analyses;Data Collection;data integration;data management;Data Set;design;Development;discount;DNA Sequence Alteration;Doctor of Medicine;Doctor of Philosophy;Education;education resources;Educational Activities;Educational workshop;empowerment;epigenome;epigenomics;Experimental Designs;experimental study;Faculty;Generations;genomic data;Genomics;Genomics Shared Resource;Goals;Grant;Growth;Hour;Human Resources;improved;insight;instrumentation;International;Interruption;Laboratories;Learning;Malignant Neoplasms;Mediation;meetings;member;Metagenomics;Methodology;Methods;Micro Array Data;Microarray Analysis;Mission;Modeling;Molecular Biology;multidisciplinary;next generation;next generation sequencing;Oncology;operation;Patient Care;Price;Principal Investigator;programs;Provider;Publications;Recording of previous events;recruit;Reporting;Research;Research Personnel;Resource Sharing;Resources;Services;Shapes;Side;single cell sequencing;skills;Speed;Structure;success;symposium;Technology;timeline;tool;transcriptomics;Translational Research;Tumor Biology

PROJECT_TITLE: Experimental and Computational Genomics


PI_NAMEs: BHUJWALLA, ZAVER M. (contact)

PROJECT_TERMS: 3-Dimensional;anti-cancer research;Award;Awards and Prizes;Cancer Center;cancer genetics;cancer imaging;Chemical Structure;Chemicals;Comprehensive Cancer Center;Contract Services;Data;Dedications;Discipline of Nuclear Medicine;Doctor of Medicine;Doctor of Philosophy;Educational workshop;Epigenetic Process;Equipment;Equipment Design;Faculty;Functional Imaging;Funding;Grant;Human;Human Resources;Image;Image Analysis;imaging capabilities;imaging facilities;imaging program;imaging study;Imaging Techniques;Imaging technology;in vivo imaging;in vivo imaging system;Infrastructure;instrument;Invaded;Investigation;Investments;lectures;Location;Magnetic Resonance Imaging;Malignant Neoplasms;mass spectrometric imaging;Mass Spectrum Analysis;member;Microscope;Molecular;molecular imaging;multi-photon;Multimodal Imaging;multiple omics;nanoparticle;NCI Center for Cancer Research;Neoplasm Metastasis;NMR Spectroscopy;nuclear division;nuclear imaging;Oncology;optical imaging;Optics;outreach program;PET/CT scan;photoacoustic imaging;Play;Positron-Emission Tomography;pre-clinical;preclinical imaging;Principal Investigator;programs;Publications;Radiology Specialty;Reporting;Research;Research Personnel;Resource Sharing;Resources;Role;Science;Services;single photon emission computed tomography;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Spectrum Analysis;structural biology;Training;translational applications;tumor immunology;Ultrasonography;ultrasound;United States National Institutes of Health;Universities;vector;Visualization

PROJECT_TITLE: Cancer Functional Imaging


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Genetics;Networking and Information Technology R&D (NITRD)

PI_NAMEs: MEEKER, ALAN KEITH (contact)

PROJECT_TERMS: Advisory Committees;Antibodies;Artificial Intelligence;Cells;cellular imaging;charge coupled device camera;clinical biomarkers;Comprehensive Cancer Center;Computer software;Confocal Microscopy;Consultations;Cryopreserved Tissue;Custom;Cytogenetics;Databases;design;digital;digital imaging;Dissection;DNA;Equipment;Fluorescence Microscopy;Fluorescent in Situ Hybridization;Formalin;G-Banding;Growth;Histology;Image;Image Analysis;Immunofluorescence Immunologic;Immunohistochemistry;In Situ Hybridization;Individual;Instruction;instrumentation;irradiation;Laboratories;laser capture microdissection;light microscopy;Manufacturer;medical schools;member;Metaphase;Methodology;Microscopy;Modality;Molecular;Molecular Analysis;Monitor;new technology;novel;Nucleic Acids;Oncology;operation;Paraffin Embedding;Paraffin Tissue;Performance;Preparation;Procedures;programs;Proteins;Protocols documentation;quantitative imaging;Reporting;Research;Research Personnel;Research Support;Resolution;Resource Sharing;RNA;Sampling;Scanning;Schedule;Services;Slide;Software Tools;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Speed;Stains;Technology;Time;Tissue Embedding;Tissue Harvesting;Tissue Microarray;tissue preparation;Tissues;Training;translational cancer research;Universities;Update;web based software

PROJECT_TITLE: Oncology Tissue and Imaging Services


PI_NAMEs: GLUNDE, KRISTINE  (contact)

PROJECT_TERMS: Acceleration;Advanced Malignant Neoplasm;Amino Acids;anti-cancer research;Biological;Biopsy;Buffers;cancer cell;Cancer Center;Cancer Model;Cardiovascular system;Cell Culture Techniques;Cell Separation;Cells;Chromatography;Co-Immunoprecipitations;Collaborations;Companions;Comprehensive Cancer Center;Computer software;cost effective;Coupled;Data Analyses;data repository;data submission;Databases;Derivation procedure;design;Detection;Dimensions;DNA analysis;drug metabolism;Educational workshop;Endocrine system;Equipment;Experimental Designs;Formalin;Freezing;Funding;gastrointestinal system;Goals;high throughput analysis;Histologic;Human;Image;Image Analysis;Immune;Individual;innovation;instrument;instrumentation;interest;Label;laser capture microdissection;lipidome;Lipids;liquid biopsy;Liquid Chromatography;Liquid substance;Malignant Neoplasms;Manuscripts;mass spectrometer;mass spectrometric imaging;Mass Spectrum Analysis;Measurement;Measures;member;metabolome;metabolomics;Modification;Molecular;molecular imaging;Molecular Target;Monitor;mouse model;multiple omics;multiplexed imaging;nano;Neurons;novel;novel therapeutics;Oncology;Operative Surgical Procedures;Organoids;Paraffin Embedding;Pathway interactions;Peptides;Pharmaceutical Preparations;Polysaccharides;Preparation;Principal Component Analysis;protein complex;Proteins;Proteolysis;Proteome;Proteomics;Protocols documentation;public repository;Reaction;Reporting;Reproductive system;Research;Research Design;Research Personnel;Resected;Resolution;Resource Sharing;Respiratory System;RNA analysis;Sampling;Services;Signal Transduction;Source;Spatial Distribution;Spectrometry;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;spheroids;Stable Isotope Labeling;Statistical Data Interpretation;Systems Biology;tandem mass spectrometry;targeted imaging;Technology;technology development;technology platform;therapeutic protein;Tissue Embedding;Tissue imaging;Tissues;Training;tumor;tumor microenvironment;tumor xenograft;tumorigenesis;two-dimensional;volcano

PROJECT_TITLE: Mass Spectrometry Molecular Imaging and Multi-Omics


PI_NAMEs: HOOPER, JODY ELIZABETH (contact)

PROJECT_TERMS: 2019-nCoV;Advanced Malignant Neoplasm;Aftercare;Anatomy;Autopsy;Benign;biobank;Biological;Biological Markers;Biological Products;Biopsy;bone;Breast;Breast Cancer Patient;Cancer Center;Cessation of life;Childhood;Clinical;Colorectal;Comprehensive Cancer Center;Consent;COVID-19 pandemic;Development;Diagnostic;disease heterogeneity;Disease Progression;Disease Resistance;DNA;Drug resistance;Formalin;Freezing;Gifts;Goals;Heterogeneity;Histopathology;image archival system;Immunotherapeutic agent;Immunotherapy;improved;Kidney;Lesion;Liquid substance;longitudinal analysis;Lung;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Melanoma;member;Molecular;molecular pathology;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Neuroepithelial, Perineurial, and Schwann Cell Neoplasm;novel therapeutic intervention;Oncology;Online Systems;Operative Surgical Procedures;Ovarian;Pancreas;Paraffin Embedding;Participant;Pathology;Patients;personalized immunotherapy;personalized medicine;Procedures;programs;Prostate;Qualifying;Quality Control;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resistance;resistance mechanism;Resource Sharing;RNA;Sampling;Sarcoma;Science;Secure;Services;Site;Source;Specimen;Specimen Handling;targeted treatment;Tissue Embedding;Tissue Microarray;Tissue Procurements;Tissue Sample;Tissues;treatment response;tumor;Tumor Cell Invasion;Tumor Tissue;Universities;Urogenital Cancer;whole slide imaging

PROJECT_TITLE: Rapid Autopsy


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Orphan Drug;Rare Diseases

PI_NAMEs: RUDEK, MICHELLE A (contact)

PROJECT_TERMS: Adult;AIDS Malignancy Consortium;Amendment;Analytical Chemistry;analytical method;anti-cancer research;Antineoplastic Agents;Applications Grants;assay development;Binding Proteins;Biological;Biological Assay;Biological Markers;Brain Neoplasms;Cancer Center Support Grant;Clinical;Clinical Pharmacology;clinical trial protocol;Clinical Trials;Comprehensive Cancer Center;cost effective;Coupled;Data Analyses;design;detector;Dose;drug development;drug discovery;Drug Kinetics;drug metabolism;Early Therapeutic-Clinical Trials Network;Ensure;Environment;experimental study;Faculty;Floor;Funding;good laboratory practice;Grant;Human Resources;In Vitro;instrument;instrumentation;ion mobility;Ions;Laboratories;Lead;Letters;Liquid Chromatography;Liquid substance;Malignant Neoplasms;Manuscripts;mass spectrometer;member;Metabolic;metabolic abnormality assessment;method development;Methods;Ohio;Oncology;Peer Review;Performance;Pharmacodynamics;Pharmacogenetics;pharmacologic;Pharmacology;Pharmacology Shared Resource;Phenotype;Plasma;Plasma Proteins;Play;pre-clinical;preclinical development;preclinical study;programs;protocol development;Protocols documentation;Publications;Recommendation;Reporting;Research;Research Design;Resource Sharing;response;Role;Sampling;Schedule;Services;Specimen;System;tool;Toxic effect;translational pipeline;translational study;Validation

PROJECT_TITLE: Analytical Pharmacology


NIH_SPENDING_CATS: Cancer;Hematology;Rare Diseases

PI_NAMEs: ROSNER, GARY L (contact)

PROJECT_TERMS: Address;anti-cancer research;Applications Grants;Area;Biological;Biometry;Biostatistical Methods;Biostatistics Shared Resource;Bone Marrow Transplantation;Cancer Center;Cancer Center Support Grant;Case Report Form;Clinical;Clinical Oncology;Clinical Research;Collaborations;Collection;Comprehensive Cancer Center;Consult;Consultations;Data;Data Analyses;Databases;design;Development;Disease;Education;Environment;Evaluation;Faculty;Funding;Goals;Grant;Hematologic Neoplasms;Immunotherapy;Individual;Information Systems;Infrastructure;Investigation;Journals;Knowledge;Laboratories;Laboratory Study;Malignant neoplasm of cervix uteri;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;Medicine;meetings;member;Mentors;Methodology;Methods;Molds;Monitor;Nature;NCI Center for Cancer Research;New England;Oncology;Patient Outcomes Assessments;Peer Review;Peer Review Grants;Population Sciences;pre-clinical;Preparation;Probability;Procedures;Process;Program Research Project Grants;programs;Progress Reports;Protocols documentation;Public Health Schools;Publications;Quality Control;Recommendation;Reporting;Reproducibility;Research;Research Design;Research Personnel;Research Support;Resource Sharing;Retrieval;Safety;Sample Size;Science;Secure;Services;success;Training;translational medicine;Translational Research;Uncertainty;Variant;Work;Writing

PROJECT_TITLE: Biostatistics


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

PI_NAMEs: JACOBS, MICHAEL A. (contact)

PROJECT_TERMS: Acceleration;Adherence;Aftercare;Algorithms;American College of Radiology Imaging Network;Anatomy;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence method;Attention;Biopsy;cancer clinical trial;Cancer Patient;cancer therapy;Caring;Classification;Clinical;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Comprehensive Cancer Center;Computer software;Consensus;Consultations;Data;deep learning;design;Detection;Development;Diagnostic Procedure;Disease;Early treatment;Eastern Cooperative Oncology Group;Ensure;FOLH1 gene;Future;Image;Image Analysis;imaging agent;imaging modality;imaging study;Imaging technology;improved;Institution;interdisciplinary approach;Lesion;Machine Learning;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;meetings;member;Metabolic;Methodology;Methods;molecular imaging;Monitor;Multimodal Imaging;NCI Center for Cancer Research;non-invasive imaging;novel;Oncologist;Oncology;oncology trial;Pathology;Patients;Phase;Positron-Emission Tomography;precision medicine;Prediction of Response to Therapy;Prognosis;programs;Protocols documentation;quantitative imaging;Radiation exposure;radiological imaging;Radiology Specialty;radiomics;Recommendation;Reporting;Reproducibility;Research;Research Design;Research Personnel;Resource Sharing;response;Sampling;Schedule;Services;Site;Specialist;Standardization;Suggestion;Therapeutic;Therapy trial;tissue processing;Tissue Sample;Tissues;tomosynthesis;Training;translational cancer research;treatment response;tumor;ultrasound;Universities;Visual;Work

PROJECT_TITLE: Image Response Assessment and Biopsy Management


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Back Pain;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Cost Effectiveness Research;Disability Research;Health Services;Opioids;Pain Research;Primary Health Care;Rehabilitation

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: This proposal will assess the capacity of Health Care Systems to move guideline-based care of low back pain (LBP) to the forefront of the patient experience by rigorously evaluating a Multidisciplinary Conservative Care Model that utilizes doctors of chiropractic and physical therapists as the first point of contact for patients with LBP. The results from this study will directly inform implementation and policy efforts to improve the quality of pain management for patients suffering from LBP while simultaneously reducing opioid prescriptions, health care costs and utilization of services.

PI_NAMEs: GOERTZ, CHRISTINE MARIE (contact);GOODE, ADAM ;LURIE, JON D

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: Adult;Age;Ambulatory Care;American;American College of Physicians;Caring;Categories;Chronic low back pain;chronic pain;Client satisfaction;Clinic;Clinical;clinical pain;Clinical Research;clinical research site;clinical trial protocol;Clinical Trials Design;Cluster randomized trial;Collaborations;collaborative care;comparative effectiveness;compare effectiveness;cost;Data Coordinating Center;disability;Doctor of Chiropractic;Documentation;Drug Prescriptions;effectiveness testing;Emergency department visit;Exercise;experience;Focus Groups;functional status;future implementation;Goals;Guidelines;Health Care Costs;health care service utilization;health service use;Health system;Healthcare Systems;Hospitalization;implementation facilitation;implementation trial;improved;incremental cost-effectiveness;informant;Infrastructure;Injections;Intervention;Interview;Iowa;Low Back Pain;Measures;Medical;Medical Care Costs;Medical center;member;Methods;Modeling;multidisciplinary;Musculoskeletal;Nonpharmacologic Therapy;Operative Surgical Procedures;Opioid;opioid epidemic;opioid mortality;opioid use;Organizational Policy;Pain;Pain interference;Pain management;Pain quality;pain reduction;pain-related disability;Patient Care;Patients;Phase;Physical Function;physical therapist;Physicians;Policies;pragmatic study;prescription opioid;Primary Care;primary care provider;primary endpoint;primary outcome;Procedures;process evaluation;Protocols documentation;Provider;Quality-Adjusted Life Years;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Reporting;Research Design;Research Institute;Resources;Risk;secondary outcome;service utilization;Site;Source;Spinal Fusion;Spinal Manipulation;Standardization;Surveys;Symptoms;System;Testing;Time;Training;treatment as usual;Universities;uptake;Visit;Work

PROJECT_TITLE: 1/2  IMPACt-LBP CCC

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Services;Patient Safety

PROJECT_TERMS: Accreditation;Adherence;Area;care systems;Caring;Certification;Clinical;Clinical Cancer Center;Clinical Data;clinical decision support;Clinical Pharmacy Service;Clinical Research;clinical trial protocol;Clinical Trials;Collaborations;Comprehensive Cancer Center;Consultations;Data Analytics;Development;Developmental Therapeutics Program;Disease;Drug Interactions;Education;Electronics;Ensure;Equipment and supply inventories;falls;improved;Individual;innovation;Inpatients;Institutional Review Boards;Investigational Drugs;Leadership;Maintenance;Maryland;medication safety;Medicine;member;Monitor;NCI Center for Cancer Research;new technology;Oncology;operation;Outpatients;Participant;Patient Care Team;Patient Monitoring;patient oriented;Patients;Pharmaceutical Preparations;Pharmaceutical Services;Pharmacists;Pharmacologic Substance;Pharmacopoeias;Pharmacy facility;Phase;Preparation;Procedures;Process;Production;programs;protocol development;Protocols documentation;quality assurance;Regulation;Reporting;Research;research and development;Research Personnel;Research Support;Residencies;Resource Sharing;Resources;Science;Services;Specialist;Sterility;Students;System;Technology;Training;Training and Education;United States;Work

PROJECT_TITLE: Research Pharmacy


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: antigen-specific T cells;Archives;Area;Biological Assay;Blood;Budgets;cancer immunotherapy;cancer therapy;Center for Translational Science Activities;CLIA certified;Clinic;Clinical;Clinical Research;Clinical Trials;Collaborations;Collection;Comprehensive Cancer Center;Consent;Correlation Studies;Custom;Data Analyses;data management;Dedications;design;Development;Documentation;effectiveness evaluation;Ensure;Equipment and supply inventories;Feedback;Freezing;Goals;Health system;Human Resources;Immune response;Immunologic Monitoring;Immunology procedure;Infrastructure;Institution;Instruction;Laboratories;laboratory manuals;Laboratory Study;Leadership;Link;Logistics;Manuals;Measures;Medical;member;Monitor;Oncology;operation;Patient Participation;Patients;Policies;Preventive;Procedures;Process;process improvement;Protocols documentation;quality assurance;Quality Control;Reporting;Research;Research Personnel;Research Training;Resource Sharing;sample collection;Schedule;Scientist;Services;Shipping;Site;Specimen;Specimen Handling;Standardization;Study Section;System;Technical Expertise;Therapeutic;Time;Tissues;Training;Translational Research;trend;Visit

PROJECT_TITLE: Translational Research Central Services


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Members of the BCL2 protein family regulate life/death decisions by modulating mitochondrial outer membrane permeability. Our previous results have demonstrated that the pro-apoptotic family member BAK is constitutively activated in a subset of acute myeloid leukemia (AML) samples as well as leukemia and lymphoma cell lines, priming them to respond to certain treatments. With an eye toward improving AML therapy, this project focuses on i) understanding the cellular and biochemical bases for this constitutive BAK activation and ii) determining the implications of constitutive BAK activation for respose to AML treatment in the clinic, using as an example the response to a novel regimen of targeted agents that is currently being developed for use in AML.

PI_NAMEs: KAUFMANN, SCOTT H (contact)

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: Acute Myelocytic Leukemia;American;Androgen Antagonists;antagonist;anti-cancer treatment;Antineoplastic Agents;Apoptosis;Apoptotic;base;BAX gene;BCL-2 Protein;BCL2 gene;BCL2L1 gene;BCL2L11 gene;Binding;Binding Proteins;Binding Sites;Biochemical;Biology;biophysical analysis;C-terminal;cancer cell;cancer therapy;Cardiolipins;Cell Death;Cell Line;Cell Membrane Permeability;cell type;Cells;Cellular Stress;Cessation of life;Clinic;Clinical;Cytoplasm;cytotoxicity;Data;design;Development;dimer;Disease;drug sensitivity;effective therapy;Enzyme Inhibitor Drugs;Epithelium;experimental study;Exposure to;Family;Family member;FDA approved;Funding;Glucocorticoids;Hematologic Neoplasms;Hematopoietic;Hematopoietic Neoplasms;Higher Order Chromatin Structure;Hormonal;Human;improved;In Vitro;in vivo;Induction of Apoptosis;inhibitor;insight;interest;Lead;leukemia;leukemia treatment;Leukemic Cell;Leukocytes;Life;Lipid Binding;Lymphoid Cell;Lymphoma cell;Malignant Neoplasms;MCL1 gene;Mediating;MEKs;member;Membrane Lipids;mimetics;Mitochondria;Molecular;monomer;Morphology;mTOR Inhibitor;Mus;Myeloid Cells;Nature;novel;Outer Mitochondrial Membrane;paralogous gene;Pathway interactions;Pattern;Peptides;Permeability;Phase;PIK3CG gene;Play;PMAIP1 gene;Positioning Attribute;postnatal;Preclinical Testing;Process;Protein Family;Proteins;Proto-Oncogene Proteins c-akt;Regimen;Regulation;research clinical testing;resistance mechanism;response;restraint;Role;Sampling;Seminal;small molecule;Specimen;Stimulus;structural determinants;Structure;targeted agent;targeted treatment;Testing;Therapeutic;Tissues;truncated BID protein;tumor

PROJECT_TITLE: BAK Autoactivation in Hematological Malignancies

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Findings from this project will determine the relationship between two vulnerability factors for Alcohol Use Disorder (AUD) in young adults: impulsivity and subjective response to alcohol. The results will identify badly needed, novel targets for prevention and treatment efforts to simultaneously reduce impulsivity and subjective responses in at-risk young adults. As such, the project is directly relevant to NIAAA’s mission to identify mechanisms of alcohol action and facilitate prevention and treatment research.

PI_NAMEs: LEEMAN, ROBERT F;WEAFER, JESSICA J (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: Accounting;addiction;adolescent alcohol misuse;age group;alcohol consequences;Alcohol consumption;alcohol effect;alcohol intervention;alcohol measurement;alcohol misuse;alcohol response;alcohol reward;alcohol sensitivity;alcohol use disorder;Alcohols;Area;Biological;Biological Markers;Biosensor;Blood alcohol level measurement;Data;design;discounting;drinking;Ecological momentary assessment;Etiology;Event;examination questions;Exanthema;Expectancy;Failure;Female;high risk;Impulsivity;Individual Differences;innovation;Intervention;Intravenous;Knowledge;Learning;lectures;Life;Link;Measures;Mediating;Mediator;Methods;Mission;Modeling;National Institute on Alcohol Abuse and Alcoholism;negative affect;novel;Outcome;Participant;Patient Self-Report;Persons;pharmacologic;Population Intervention;preference;Prevention;Prevention Research;protective factors;Public Health;Publishing;Research;response;Rewards;Risk;Risk Factors;Role;Sedation procedure;Self Administration;Sex Differences;Testing;theories;Time;trait;treatment research;women versus men;Wrist;young adult;young woman

PROJECT_TITLE: Linking Impulsivity Domains and Subjective Response to Alcohol in Young Adults Using Lab and Daily Assessment Methods


NIH_SPENDING_CATS: Biotechnology;Diabetes;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Nutrition

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: Project Narrative  Diabetic retinopathy (DR) is a common and sight-threatening complication of diabetes. Placental growth factor (PlGF) has emerged as a promising target molecule to treat DR, yet how PlGF mediates DR pathogenesis remains incompletely understood. This project will elucidate a new mechanism for PlGF to mediate diabetes-induced retinal pathology by reprogramming glucose metabolism, determine the protective role of glucose-6-phosphate dehydrogenase (G6PD)’s antioxidant function via oxidative pentose phosphate pathway (oxPPP) in DR, and explore a new intervention approach to prevent or delay DR progression by increasing G6PD activity and oxPPP flux.

PI_NAMEs: HUANG, HU  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Address;antioxidant enzyme;Antioxidants;Apoptosis;Apoptotic;Area;Automobile Driving;Belief;Blindness;Blood-Retinal Barrier;Breeding;Cell Culture Techniques;Cell Survival;Cells;Cessation of life;Clinical;Complications of Diabetes Mellitus;conditional knockout;CRISPR/Cas technology;dehydroepiandrosterone;design;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Retinopathy;Endothelial Cells;Erythrocytes;experimental study;expression vector;extracellular;Eye;FOXO1A gene;Functional disorder;gain of function;Gene Expression Profile;Gene Silencing;Gene Transfer;Genetic Models;genome editing;Glucose;glucose metabolism;Glucosephosphate Dehydrogenase;Glucosephosphate Dehydrogenase Deficiency;Glycolysis;Goals;HDAC9 gene;Homeostasis;Human;Impairment;In Vitro;in vivo;innovation;insight;Intervention;kidney cell;knock-down;Knock-out;Knockout Mice;Knowledge;Label;Lentivirus;Ligands;liquid chromatography mass spectrometry;LoxP-flanked allele;macular edema;MAP Kinase Gene;Measurement;Measures;Mediating;Metabolic;metabolomics;Mitochondria;mitochondrial dysfunction;Mononuclear;mouse model;Muller's cell;Mus;NADP;Natural regeneration;Neurons;novel;novel strategies;Outcome;overexpression;Oxidation-Reduction;oxidative damage;Oxidative Stress;Oxidative Stress Induction;Oxygen Consumption;Pathogenesis;Pathology;Pentosephosphate Pathway;PGF gene;Pharmacologic Substance;Phenotype;Phosphotransferases;PI3K/AKT;Play;Predisposition;prevent;protective effect;protective pathway;Reaction;receptor;Reduced Glutathione;Regulation;Reporting;Research;Retina;retinal damage;retinal rods;Rod;Role;Signal Pathway;Signal Transduction;small hairpin RNA;small molecule;Stable Isotope Labeling;STAT1 gene;stem cells;Streptozocin;Stress;System;Testing;Tissues;Tracer;transcription factor;Transfection;translational potential;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factors;vector;Virulence Factors;Virus;Vision

PROJECT_TITLE: Regulation of blood-retina barrier by placental growth factor

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]