NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: MISCELLANEOUS

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Narrative We will test and refine a novel brain-stimulation tool using gamma-frequency lights coupled with self-selected music for a gamma-music-based intervention for participants with mild Alzheimer’s Disease. Results will yield a gamma-stimulation protocol that reliably influences brain activity (Aim 1), is adaptive, motivating and rewarding to use (Aim 2), and will generate predictions as to who might benefit the most from gamma-MBI (Aim 3). By bridging the gap between neurostimulation and behavioral intervention by combining music therapy with gamma- band neurostimulation, the present project aims to find a sustainable intervention that delays the progression of AD.

PI_NAMEs: LARGE, EDWARD W;LOUI, PSYCHE  (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: Acoustics;Address;Adopted;Aging;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-Protein;Atrophic;Attention;Auditory;Auditory area;behavior prediction;Behavior Therapy;Behavioral;Brain;brain based;cerebral atrophy;Cognition;Cognitive;Cognitive deficits;cognitive function;comparison control;Complex;compliance behavior;Coupled;Coupling;Deposition;design;detector;Disease Progression;efficacy evaluation;Electroencephalography;Emotions;extracellular;Frequencies;Functional Magnetic Resonance Imaging;Goals;Gold;Hippocampus;Human;improved;Individual;Individual Differences;innovation;interest;Intervention;intervention participants;Laboratory Study;Language;Learning;lifestyle intervention;Light;Link;Memory;Memory impairment;Memory Loss;memory recognition;Methods;molecular marker;Moods;motivated behavior;Motivation;mouse model;Movement;Music;Music Therapy;neural;neural circuit;neural model;neural network;Neurocognitive;Neurons;noninvasive brain stimulation;novel;novel therapeutics;older adult;Participant;Patients;Performance;Periodicity;Phase;Photic Stimulation;Population;preservation;prevent;Protocols documentation;Qualifying;Quality of life;response;Rewards;Route;Senile Plaques;Sensory;sensory cortex;social;social attachment;success;symptom management;Synapses;System;tau Proteins;Technology;Testing;Time;tool;Translating;United States National Institutes of Health;Visual;visual stimulus;Work

PROJECT_TITLE: Gamma-Music Based Intervention for Mild Alzheimer's Disease


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Murray

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: IHC HEALTH SERVICES, INC.

ORG_STATE: UT

PHR: PROJECT NARRATIVE Sepsis affects 5-10% of hospitalized patients and kills 11 million people worldwide each year. Prompt treatment improves sepsis outcomes, but optimal antibiotic initiation thresholds, fluid resuscitation practices, and triage strategies are often unclear for individual patients. This research program will investigate how and why different physicians manage patients with sepsis in different ways, helping reduce sepsis morbidity and mortality by generating evidence that will guide selection and delivery of personalized sepsis treatment.

PI_NAMEs: PELTAN, ITHAN DANIEL (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Accident and Emergency department;Affect;Antibiotics;Area;Big Data;Caring;Clinical Data;Data Set;Decision Making;design;Epidemiology;Future;Health system;Hospitalization;improved;individual patient;Infection;Investigation;IV Fluid;Learning;Life;Liquid substance;Measures;Methods;Morbidity - disease rate;mortality;National Institute of General Medical Sciences;optimal treatments;Organ failure;Outcome;Patients;Persons;Phenotype;Physicians;Process;programs;Qualitative Research;Research;Research Methodology;Research Personnel;Research Priority;Resuscitation;Sepsis;statistical and machine learning;support tools;Syndrome;tool;treatment and outcome;treatment strategy;Triage;Variant

PROJECT_TITLE: Measuring and Learning from Care Variation in Sepsis

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Hypertension;Infant Mortality;Orphan Drug;Pediatric;Prevention;Pulmonary Hypertension;Rare Diseases;Transplantation

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because delineation of the pathophysiologic mechanism responsible for symptomatic deterioration and right heart failure, a leading cause of cardiovascular death in young Americans, will help inform improved prevention and early treatment strategies for right heart failure that, in turn, will save lives, reduce morbidity, and reduce healthcare costs. Successful completion of the pro- posed research in this application will provide strong justification for future clinical trials to determine the sur- vival benefits of pulmonary valve replacement performed at different stages of disease pathogenesis. The pro- posed research is relevant to the part of the NIH’s mission pertaining to the pursuit of knowledge to extend healthy life and reduce the burdens of illness and disability.

PI_NAMEs: EGBE, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, BRYANNA NICOLE

PROJECT_TERMS: Acceleration;Adult;Aerobic;Age;American;arm;Arrhythmia;Biological Markers;Blood Tests;burden of illness;cardiac magnetic resonance imaging;Cardiovascular system;Cessation of life;Chronic;Clinical;Clinical Trials;cohort;Complication;Data;Deterioration;Development;Diagnostic;disability;Disease;Early treatment;Echocardiography;effective therapy;Enrollment;Event;evidence base;Exercise Test;extracellular;follow-up;Future;Goals;Health Care Costs;Heart;Heart Atrium;hemodynamics;Hypertension;Image;Impairment;improved;improved outcome;indexing;Inferior vena cava structure;innovation;Knowledge;Laboratories;Life;Life Expectancy;Link;Mission;Morbidity - disease rate;mortality;novel therapeutics;Operative Surgical Procedures;Outcome;Oxygen Consumption;Pathogenesis;Patients;Persons;Population;Postoperative Period;premature;pressure;prevent;Prevention;Prevention therapy;pro-brain natriuretic peptide (1-76);Process;Public Health;Pulmonary Valve Insufficiency;pulmonary valve replacement;Recurrence;repaired;Reporting;Research;right ventricular failure;Risk;Risk Factors;symptomatic improvement;Symptoms;Techniques;Testing;Tetralogy of Fallot;Therapeutic Intervention;Time;treatment strategy;Troponin;Uncertainty;United States National Institutes of Health;Ventricular Arrhythmia

PROJECT_TITLE: Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of Fallot

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: CAMDEN

ORG_DEPT: BIOLOGY

ORG_NAME: RUTGERS THE STATE UNIV OF NJ CAMDEN

ORG_STATE: NJ

PHR: Public Health Relevance Statement  Peptide ligand-mediated signaling is integral to the development of multicellular organisms and their adaptation to the environment, dysregulation of which contributes to many prevalent human diseases, including cancer, diabetes, immune-related diseases, and neurological disorders. The proposed study aims at elucidating the osmotic regulation of a classical peptide ligand-mediated signaling pathway. It involves mechanisms of transcriptional regulation, protein subcellular behaviors, protein stability regulation, and cell-state transitioning, all of which are clearly related to the studies of human signaling pathways.

PI_NAMEs: QI, XINGYUN  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TITLE: Osmotic Regulation of a Peptide Ligand-Mediated Signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Overall The proposed studies will identify mechanisms that promote both non-alcoholic steatohepatitis and atherosclerosis, providing a rational basis for development of therapeutic approaches that would have a beneficial impact on both diseases.

PI_NAMEs: GLASS, CHRISTOPHER K (contact)

PROGRAM_OFFICER_NAME: KIRBY, RUTH

PROJECT_TERMS: Acetaldehyde;adduct;Affect;Antibodies;Arteries;Atherosclerosis;Bioinformatics;Bioinformatics Shared Resource;Biological Assay;Biological Markers;biomarker performance;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cirrhosis;Clinical;Clinical Trials;cohort;Cohort Studies;Collaborations;Collagen;coronary calcium scoring;cytokine;density;Desmosterol;Development;Disease;disease phenotype;Doctor of Philosophy;effective therapy;elastography;Environmental Risk Factor;Epigenetic Process;Epitopes;Fatty acid glycerol esters;Fatty Acids;Fatty Liver;Fibroblast Growth Factor;Fibrosis;Gene Expression Profile;Genetic;Genomics;Glass;Goals;Health;Hepatic;Homeostasis;Human;human disease;human subject;Hypertriglyceridemia;In Vitro;Incidence;Inflammation;Insulin Resistance;Intervention;Intestines;Kupffer Cells;lipid biosynthesis;lipidomics;Lipoproteins;Liver;Liver X Receptor;Lysophosphatidylcholines;Macrophage;Magnetic Resonance Imaging;Malondialdehyde;Massive Parallel Sequencing;Measurement;Measures;Mediating;Metabolism;mimetics;monocyte;mortality;mouse model;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Obesity;Outcome;oxidation;Participant;Patients;peripheral blood;Phenotype;Phospholipids;Population;Process;prospective;Protons;receptor;Receptor Cross-Talk;receptor function;recruit;Risk;Risk Factors;Role;Sampling;Signal Transduction;small molecule;stable isotope;Statistical Data Interpretation;Techniques;Testing;Therapeutic;therapeutic development;Tissues;transcriptome sequencing

PROJECT_TITLE: A Cardiovascular-NASH disease nexus: Common Mechanisms and Treatments?

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(JA)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Maternal Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: LITTLE ROCK

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Relevance Documenting fetal and brain assessments and comparing them with maternal inflammatory biomarkers in diabetic pregnancy will provide novel insight into mechanisms reported previously in strictly observational studies of maternal inflammation and adverse infant outcome to identify targets for potential therapeutic options and interventional treatments in diabetic pregnancy.

PI_NAMEs: ESCALONA-VARGAS, DIANA  (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: adverse maternal outcomes;Attention;Auditory Evoked Potentials;auditory stimulus;bioelectricity;Biological Markers;Blood;Blood Glucose;Blood specimen;Brain;Brain-Derived Neurotrophic Factor;C-reactive protein;Caring;Characteristics;Child;Clinical;comorbidity;cytokine;Data;delivery complications;Development;Diabetes Mellitus;diabetic;Diabetic mother;Environment;Epidemiology;Etiology;Female of child bearing age;fetal;Fetal Heart;Fetus;follow-up;General Population;Glucose;glycemic control;Goals;Growth;Health;High-Risk Pregnancy;Human;Hypertension;Impaired cognition;Impairment;improved;inattention;indexing;Infant;Infant Health;infant outcome;Inflammation;Inflammatory;inflammatory marker;inflammatory modulation;insight;Insulin-Dependent Diabetes Mellitus;Interleukin-6;Intervention;Investigation;Language Delays;Language Development;Life;Link;Magnetoencephalography;maternal diabetes;maternal risk;Medical;Monitor;Mothers;motor deficit;multimodality;Neonatal;neonatal brain;neonate;neural growth;neurobehavioral;neurodevelopment;Neurodevelopmental Deficit;Neurologic;neurophysiology;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Observational Study;offspring;Outcome;Prediabetes syndrome;Pregnancy;Pregnancy in Diabetics;pregnant;Prevalence;Process;Protocols documentation;Psychopathology;Reporting;reproductive;response;Risk;Risk Factors;Sampling;Schedule;sensor;signal processing;Signal Transduction;Solid;Source;System;systemic inflammatory response;targeted treatment;Techniques;Therapeutic;Therapeutic Intervention;Third Pregnancy Trimester;Time;type I and type II diabetes;Umbilical Cord Blood;Visit;Visual evoked cortical potential;visual stimulus

PROJECT_TITLE: Magnetoencephalography based tracking of fetal neurodevelopment in diabetic pregnancies

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease

PROJECT_TERMS: Advisory Committees;Atherosclerosis;Cardiovascular system;data sharing;Decision Making;Disease;Ensure;Gene Expression;Glass;Inflammation;Infrastructure;meetings;model organism;nonalcoholic steatohepatitis;Preparation;Program Research Project Grants;programs;Progress Reports;Research Personnel;Resource Sharing;Resources;statistics;Structure

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Disease

PI_NAMEs: WITZTUM, JOSEPH L. (contact)

PROJECT_TITLE: PPG Phenotyping


NIH_SPENDING_CATS: Atherosclerosis;Biotechnology;Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Human Genome;Liver Disease

PI_NAMEs: BENNER, CHRISTOPHER W (contact)

PROJECT_TERMS: ATAC-seq;Atherosclerosis;base;Bioinformatics;Biological Assay;Cardiovascular system;cell type;Cells;ChIP-seq;Chromatin;Collection;computer infrastructure;Computer software;computerized data processing;computerized tools;computing resources;Core Facility;Data;deep sequencing;Development;dietary;Disease;DNA;experimental study;Gene Expression;Gene Expression Profiling;Genetic;Genetic Transcription;Genome Mappings;genomic locus;Genomics;Glass;Infrastructure;Laboratories;Libraries;Macrophage;Massive Parallel Sequencing;Measures;Methodology;Methods;nonalcoholic steatohepatitis;Pathologic;pharmacologic;Preparation;Procedures;programs;Proteins;Protocols documentation;Public Domains;Publishing;reference genome;Resources;RNA;Scientist;Secure;Services;single-cell RNA sequencing;skills;Software Tools;Standardization;supercomputer;Tissues;transcription factor;transcriptome sequencing;Visualization;Work

PROJECT_TITLE: Genomics Bioinformatics


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Liver Disease

PROJECT_TERMS: ADD-1 protein;Affect;Agonist;Antiinflammatory Effect;Arterial Fatty Streak;Arteries;Atherosclerosis;Binding;Cardiovascular Diseases;Cardiovascular system;cell type;Cells;Cholesterol;clinical investigation;Collaborations;Coupled;Desmosterol;Development;Diet;Disease;disease phenotype;Enhancers;Environmental Risk Factor;Epigenetic Process;Epitopes;Event;Family;Fatty Acids;fatty liver disease;Fibroblast Growth Factor;Fibrosis;Foam Cells;Gene Expression Profile;Genes;Genetic;genetic approach;Hepatocyte;Homeostasis;human subject;Hypertriglyceridemia;Impairment;in vivo;Individual;Insulin Resistance;Kupffer Cells;Ligands;Liver;Liver diseases;liver function;Liver X Receptor;longitudinal, prospective study;Macrophage;member;mimetics;monocyte;Morbidity - disease rate;mouse model;Mus;Myelogenous;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;Nuclear Receptors;Obesity;oxidation;Pathway interactions;peripheral blood;pharmacologic;Phenotype;Play;Population;Prevention;Process;Regulation;response;reverse cholesterol transport;Role;Severities;Signal Transduction;Testing;transcription factor;United States

PROJECT_TITLE: Macrophage-specific targeting of LXRs in CVD and NASH


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Kidney Disease;Nanotechnology;Organ Transplantation;Regenerative Medicine;Transplantation

ORG_CITY: VILLANOVA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VILLANOVA UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative This project aims to develop a multi-faceted therapeutic strategy to reduce ischemia reperfusion injury related damage to the endothelium of transplanted kidneys. We propose that polymeric vehicles specifically tailored for endothelial cells will be able to efficiently deliver and sustain the release of siRNA to prevent these injury outcomes by temporarily silencing the key molecules in each case that propagate inflammation outside of the cell. This modular approach will allow us to address the two key sources of injury to endothelium and substantially reduce the impact of IRI for kidney transplant.

PI_NAMEs: BRACAGLIA, LAURA  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Address;Amines;Area;Arteries;Award;Biocompatible Materials;Biology;Biomedical Engineering;bioscaffold;Blood capillaries;Blood Vessels;Cell Adhesion Molecules;Cell Communication;cell injury;Cells;Characteristics;Charge;Chemicals;Clinical;clinical translation;Coupling;delivery vehicle;density;design;Development;Doctor of Philosophy;Drug Delivery Systems;Endothelial Cells;Endothelium;Environment;Extracellular Matrix;Family;Fibrosis;Formulation;Goals;graft failure;Health;Human;human model;human tissue;Hydrogels;Hypoxia;Immune;Immunology;Immunosuppressive Agents;improved;In Vitro;in vivo;in vivo Model;Infiltration;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injections;injured;Injury;Injury to Kidney;insight;Intercellular adhesion molecule 1;Kidney;kidney cortex;Kidney Transplantation;Kinetics;knock-down;Knowledge;Leukocytes;Long-Term Effects;Measures;Mediating;meetings;Mentors;Methods;Molecular;nanoparticle;nanoparticle delivery;nanopolymer;Natural regeneration;Neutrophil Infiltration;novel;nucleic acid delivery;Nucleic Acids;Organ;Organ Model;Organ Transplantation;Outcome;Pathology;Penetration;Perfusion;Phase;Placenta;Polymers;Postdoctoral Fellow;prevent;Production;Profibrotic signal;rational design;regeneration potential;renal damage;Reperfusion Injury;resilience;response;response to injury;Risk;Route;Science;siRNA delivery;Site;Small Interfering RNA;small molecule;Source;Structure;System;targeted treatment;Technical Expertise;Therapeutic;therapeutic nanoparticles;therapeutic siRNA;therapy duration;three-dimensional modeling;Tissue Model;Tissues;tool;Training;Transfection;Translating;translation to humans;Transplantation;treatment strategy;Tubular formation;Universities;uptake;Vascular Cell Adhesion Molecule-1;vascular inflammation;Work

PROJECT_TITLE: Tailored siRNA delivery to human endothelium to inhibit and reverse inflammatory damage following ischemia reperfusion injury in the kidney

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: PROJECT NARRATIVE Relevance to public health: Sepsis is a common and serious clinical condition and the number one killer of hospitalized patients. Early detection and treatment are crucially important for an improved outcome, therefore there is an acute need for accurate biomarkers for early diagnosis, prognosis and guiding therapy. Relevance to the NIGMS mission: Identification, characterization, and validation of sepsis-specific biomarkers particularly in the context of enabling endotyping strategies or future evaluation of diagnostics and novel therapies is one of NIGMS priorities on sepsis research (NOT-GM-19-054).

PI_NAMEs: LUPU, FLOREA  (contact);TACKETT, ALAN

PROJECT_TERMS: Accounting;Acute;Address;Bacteremia;Bacteria;Bioinformatics;Biological;Biological Markers;biomarker development;biomarker discovery;biomarker evaluation;biomarker identification;biomarker panel;biomarker signature;biomarker validation;Blood specimen;Blood Tests;candidate marker;candidate validation;Cardiovascular Diseases;Cause of Death;Cessation of life;Clinical;clinical development;cohort;comorbidity;Complex;Coupled;Data;Data Set;Development;Diabetes Mellitus;Diagnosis;Diagnostic;diagnostic tool;differential expression;Disease;Dose;drug development;early detection biomarkers;Early Diagnosis;Early treatment;Escherichia coli;Evaluation;experience;experimental study;Foundations;Functional disorder;Future;Goals;Hospital Costs;Hospitalization;Human;Immune response;Immune system;Immunoassay;improved outcome;Infection;Infrastructure;instrumentation;Life;Malignant Neoplasms;Maps;Mass Spectrum Analysis;medical attention;Methods;microbial;Mission;Modeling;Monitor;multidisciplinary;National Institute of General Medical Sciences;nonhuman primate;novel;novel marker;novel therapeutics;Oklahoma;Organ;Papio;pathogen;Pathologist;patient stratification;Patients;performance tests;personalized medicine;Plasma;Positioning Attribute;predictive marker;Prognosis;protein biomarkers;Proteome;proteomic signature;Proteomics;Public Health;Qualifying;Race;Research;research clinical testing;Resources;Sampling;Scientist;Sepsis;septic patients;Septic Shock;Septicemia;Source;Specialist;specific biomarkers;Standardization;Staphylococcus aureus;statistics;Syndrome;targeted treatment;Testing;Therapeutic;Time;Tissue Sample;Translating;treatment strategy;Validation;validation studies

PROJECT_TITLE: Discovery and Characterization of Novel Sepsis Proteome Biomarkers

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Heart Disease;Hepatitis;Liver Disease

PI_NAMEs: EVANS, RONALD M (contact)

PROJECT_TERMS: Affect;Agonist;Apolipoproteins;Arterial Fatty Streak;atherogenesis;atheroprotective;Atherosclerosis;Automobile Driving;Bile Acids;Biliary;biobank;Biological;Biological Markers;blood glucose regulation;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Carotid Artery Ulcerating Plaque;Cells;Cholesterol;Cholesterol Homeostasis;Clinical;Collaborations;comparative;Coronary Arteriosclerosis;Deposition;Development;Dietary Component;Disease;disease model;disorder risk;Epitopes;Excretory function;Extrahepatic;fatty liver disease;FGF19 gene;Fibroblast Growth Factor;Fibrosis;Foam Cells;Functional disorder;gain of function;Genetic;Genetic Transcription;Goals;Hepatic;Hepatitis;High Density Lipoproteins;human disease;hypercholesterolemia;Hyperlipidemia;In Vitro;indexing;Inflammation;insight;Insulin Resistance;Intestines;Lesion;Lipids;Lipoproteins;Liver;Liver diseases;liver injury;loss of function;Lysophosphatidylcholines;Macrophage;Mediating;Metabolism;Modeling;mouse model;Mus;nonalcoholic steatohepatitis;oxidation;Pathway interactions;patient population;Patients;Peptides;pharmacologic;Physiology;pre-clinical;Predictive Value;programs;protective effect;receptor;Receptor Activation;Receptor Cross-Talk;receptor expression;Regulation;repaired;Reporting;repository;reverse cholesterol transport;Risk;Role;Sampling;Serum;Signal Transduction;Steatohepatitis;sterol homeostasis;targeted treatment;Tissues;Triglycerides

PROJECT_TITLE: Tissue-specific roles of FXR in CVD and NASH


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Nanotechnology;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: CHEMISTRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Current chemotherapeutic treatments for brain cancers such as glioblastoma are not able to meaningfully extend the lifespans of patients. We have developed dye molecules that emit in the near-infrared region (1100 – 1300 nm), and when irradiated, produce localized heat - by encapsulating these dyes into polymeric nanoparticles and coating the particles with ionic liquids, we can vastly increase the amount of drug that can be delivered to the brain and act as a theranostic, enabling high-resolution imaging and selective cell death. This proposal will generate new dyes, polymers, and ionic liquid formulations and will establish their photophysical properties, safety and efficacy in complementary in vitro and in vivo models.

PI_NAMEs: WATKINS, DAVITA L. (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Acute;Adult;Affinity;Anesthesia procedures;Anions;Astrocytes;Behavior;Biodistribution;bioimaging;Biological;Bioluminescence;biomaterial compatibility;Blood;Blood - brain barrier anatomy;blood-brain barrier penetration;Brain;Brain imaging;brain tissue;Cancerous;Catheterization;Cations;Cell Death;cell type;Cells;Charge;chemotherapy;Coculture Techniques;copolymer;Data;delivery vehicle;Development;Diagnosis;Diffuse;disease model;Dose;Drug Delivery Systems;Drug Kinetics;Dyes;efficacy evaluation;Encapsulated;Erythrocytes;Excision;extend lifespan;Fluorescence;fluorescence imaging;Fluorescent Probes;Formulation;frontal lobe;Glioblastoma;Glioma;Goals;Growth;Hemolysis;high resolution imaging;Hour;Human;hydrophilicity;Hydrophobicity;Image;Immune response;Immune Sera;immunodeficiency;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Incubated;Injections;Intracarotid;Lasers;lead candidate;Libraries;Light;light scattering;liquid formulation;Liquid substance;Literature;Luciferases;Malignant neoplasm of brain;Measures;Mediating;Microglia;Modality;Modeling;molecular imaging;Monitor;Mus;nanocarrier;nanoparticle;nanoparticle delivery;nanopolymer;nanotheranostics;Nature;neoplastic cell;Nervous System Disorder;neuro-oncology;Neuroimmune;Noise;novel;Organ;Organic Synthesis;particle;patient prognosis;Patients;Penetration;Pharmaceutical Preparations;Pharmacology;Polymers;preference;Property;Rattus;Relaxation;Reporting;reproductive;Resolution;Route;Safety;safety assessment;Salts;self assembly;Shapes;Short Waves;Signal Transduction;Slice;small molecule;Specificity;Stains;Surface;Technology;Temperature;theranostics;Therapeutic;Tissues;tumor;tumor growth;Visualization;Water;Work;Xenograft procedure

PROJECT_TITLE: Ionic Liquid-Coated NIR-II Polymer Conjugates as Targeted Brain Theranostics


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cardiovascular;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Heart Disease;Hepatitis;Liver Disease;Prevention

PI_NAMEs: LOOMBA, ROHIT  (contact)

PROJECT_TERMS: Adult;attenuation;biobank;Biological Markers;Biological Specimen Banks;Biopsy;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cholesterol Homeostasis;circulating biomarkers;Clinical;Clinical Data;clinical practice;Clinical Research;cohort;Cohort Studies;Collaborations;coronary artery calcification;coronary calcium scoring;cost;Data;Data Set;Databases;density;Development;diabetic;diagnosis standard;Disease;elastography;end stage liver disease;epidemiology study;Epitopes;Fatty acid glycerol esters;Fibrosis;Framingham Heart Study;Goals;Grain;Hepatic;Hepatic Fibrogenesis;high risk;Histologic;Human;imaging biomarker;imaging modality;Imaging technology;Individual;Intraobserver Variability;Investigation;Knowledge;lipid biosynthesis;Liver;liver biopsy;Liver Fibrosis;liver imaging;liver transplantation;Magnetic Resonance;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Measurement;Measures;Metabolic syndrome;mortality;multidisciplinary;Noise;non-alcoholic fatty liver;non-alcoholic fatty liver disease;non-invasive imaging;nonalcoholic steatohepatitis;novel;Outcome;oxidation;Participant;participant enrollment;Pathogenicity;Patients;Persons;Phenotype;Pilot Projects;Population;potential biomarker;Process;prospective;Protons;Research;Research Personnel;Resources;Risk;Risk Assessment;Risk Factors;risk stratification;Role;Sampling Errors;screening;Site;study population;Surrogate Markers;Techniques;Testing;therapeutic target;ultrasound;United States;Validation;validation studies;vibration

PROJECT_TITLE: Role of liver fat and fibrosis in human CVD risk phenotypes.


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Data Science;Infectious Diseases;Machine Learning and Artificial Intelligence

ORG_CITY: NAIROBI

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: INTERNATIONAL CENTRE OF INSECT PHYSIOLOG

PHR: Project Narrative The Research Training program “Eneza Data Science: Enhancing Data Science Capability and Tools for Health in East Africa” will build on existing and new partnerships in data science, enabling system thinking across disciplines in clinical practice, and health research in an integrative approach. ICIPE will lead the program, with partners in Kenya (Aga Khan, USIU- Africa and Pwani universities), and international partners in the University of Michigan and Open Philanthropy, to enhance data science skills so that information in raw and often disparate data can be harnessed for healthcare improvement. The Eneza Data Science project aims to empower clinicians, health personnel, health researchers, and data science researchers with open science skills and tools to turn data into meaningful insights for better health, building on collaborations developed through the Human Heredity & Health in Africa, and the UZIMA DS-I Africa project hosted at Aga Khan University (Kenya) to 1) build a robust research and training platform, 2.) enhance data science knowledge, and 3.) build skills in data science, in order to benefit in Nairobi.

PI_NAMEs: ALI, AMINA ABUBAKAR;MASIGA, DANIEL KANANI (contact);NGUGI, ANTHONY KARANJA

PROGRAM_OFFICER_NAME: POVLICH, LAURA

PROJECT_TERMS: Adolescent and Young Adult;Africa;African;Artificial Intelligence;Attention;Awareness;Bioinformatics;bioinformatics network;Biological Sciences;career development;Child;climate data;Clinical;clinical practice;Collaborations;Communicable Diseases;Communities;cost;Data;Data Analyses;Data Science;Data Set;Decision Making;design;Discipline;Disease;Disparate;Eastern Africa;empowerment;Ethics;experience;Foundations;Generations;Genome;genome sequencing;Growth;hackathon;Health;Health Benefit;health care service;Health Personnel;Health Sciences;health training;Healthcare;Heredity;Human;Human Genetics;Human Resources;human subject;improved;India;Individual;insight;International;Internships;Kenya;Knowledge;Lead;Machine Learning;Measurable;Mental Health;Mentorship;Michigan;Microbial Genetics;Modeling;Mothers;open data;Outcome;Output;pathogen;Personal Satisfaction;personalized intervention;programs;Reproducibility;Research;Research Personnel;Research Training;Risk;Service setting;skills;statistics;Structure;Students;System;Thinking;tool;Training;Training Programs;United States;Universities;vector;Vision

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-L(70)R]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Cost Effectiveness Research;Maternal Health;Maternal Morbidity and Mortality;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will yield high quality evidence on the effectiveness of the Jada® System in the management of postpartum hemorrhage, the leading cause of maternal mortality worldwide, responsible for 25% of maternal deaths from obstetric causes, with 99% occurring in low and lower-middle income countries (LMICs). If proven effective, safe and cost-effective, this simple and scalable device would have a profound impact on PPH-related maternal mortality and morbidity worldwide, especially in LMICs.

PI_NAMEs: TUULI, METHODIUS GAMUO (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Accounting;Adverse event;arm;Balloon Dilatation;Beds;Blood Vessels;Case Series;Catheters;Childbirth;Clinical Trials;condoms;constriction;Contracts;Control Groups;cost;cost effective;cost effectiveness;cost estimate;cost per quality-adjusted life year;Data;design;Devices;Discipline of obstetrics;Effectiveness;effectiveness evaluation;Endometritis;Enrollment;Event-Related Potentials;experience;Ghana;global health;Health;Hemorrhage;Hemostatic function;Hour;Hypovolemia;Hypovolemics;Hysterectomy;improved;Incidence;incremental cost;Indonesia;Injury;Ligation;low and middle-income countries;Massage;maternal morbidity;Maternal Mortality;maternal outcome;Measures;Mechanics;Medical;multidisciplinary;novel;Operative Surgical Procedures;Outcome Study;Physiological;Physiology;Placenta;Postpartum Hemorrhage;Postpartum Period;pressure;Preventive measure;prophylactic;Public Health;randomized trial;Randomized, Controlled Trials;relative effectiveness;reproductive tract;Research;Research Personnel;Route;Safety;safety assessment;Sample Size;Selection Bias;standard care;Surgical sutures;Symptoms;System;Testing;Therapeutic;Third Stage Labor;Time;Traction;United States;Urinary tract;Uterine Contraction;Uterine hemorrhage;Uterine Inertia;Uterine Perforation;Uterine Rupture;Uterus;Vacuum;Woman

PROJECT_TITLE: Novel Vacuum-Induced Postpartum Hemorrhage Control: a Multicenter Randomized Trial.


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Heart Disease;Nutrition;Obesity;Patient Safety;Physical Activity;Prevention

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Over one third of American adults have obesity. Lifestyle interventions, the first-line treatment for this disease, do not produce lasting weight loss for most patients. Antiobesity medications can help to increase the amount and duration of weight loss when paired with lifestyle change, especially if used long term, but brand-name medications are costly and often not covered by insurance. Phentermine is a generic antiobesity medication which is affordable but only approved for short-term use. It is not known whether phentermine will be both effective and safe for long-term weight loss. We will conduct a randomized clinical trial to compare weight loss and other health outcomes for patients assigned to take phentermine or placebo for up to two years.

PI_NAMEs: ARD, JAMY D;LEWIS, KRISTINA H (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Address;Adult;Adverse event;American;Atherosclerosis;Basal metabolic rate;behavior change;Behavior Therapy;behavioral study;Blood Pressure;Body mass index;Body Weight;Body Weight Changes;Body Weight decreased;Cardiac;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cessation of life;Clinical;clinical practice;Clinical Trials;clinically significant;comorbidity;cost;Data;Data Coordinating Center;Diabetes Mellitus;dietary;Disease;Distant;Drug Prescriptions;Drug usage;Effectiveness;efficacy outcomes;Electrocardiogram;Electronic Health Record;Eligibility Determination;energy balance;Energy Intake;Enrollment;Event;evidence base;Future;Glycosylated hemoglobin A;Guidelines;Health;Heart Rate;Hypertension;improved;innovation;Insurance;Intervention;Label;Life Style;lifestyle intervention;Lipids;Maintenance;Mediating;Names;new therapeutic target;novel;obese patients;Obesity;obesity treatment;Observational Study;off-label use;Outcome;Outcome Measure;Participant;patient subsets;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phentermine;Physical activity;Placebos;Practice Management;primary outcome;programs;Publishing;randomized placebo controlled trial;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Research;Risk;Risk Factors;Serious Adverse Event;stem;Sympathomimetics;tool;treatment guidelines;United States;uptake;waist circumference;Weight;Weight maintenance regimen

PROJECT_TITLE: 1/2, Clinical Coordinating Center for the Long-term Effectiveness of the Anti-obesity medication Phentermine: the LEAP Trial

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Pregnancy is an opportunity to screen women at high-risk for cardiovascular disease so that prevention strategies can be implemented. Arterial stiffness measured by pulse wave velocity is a marker for cardiovascular disease risk. This study enrolls mother-infant pairs from healthy pregnancies and those complicated by adverse perinatal outcomes to measure maternal and infant arterial stiffness by pulse wave velocity and cardiovascular biomarkers. We will longitudinally estimate cardiovascular disease risk in healthy and medically complicated pregnant women and their infants from birth to three years postpartum.

PI_NAMEs: BOGGESS, KIM A;MEYER, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: REIS, JARED P

PROJECT_TERMS: Address;adiponectin;Adult;adverse outcome;adverse pregnancy outcome;Affect;Age;Aging;arterial stiffness;Biological;Biological Markers;Biological Process;Biological Specimen Banks;Birth;Black Populations;Black race;Blood Pressure;Blood Vessels;Cardiology;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;Cardiovascular system;Cause of Death;Characteristics;Child;Childhood;cohort;Complex;Data;data repository;Diet;Disease;early childhood;Early Diagnosis;Enrollment;Epigenetic Process;ethnic difference;Ethnic Origin;evidence base;Exercise;experience;Family;Female;Fetal Growth Retardation;Future;Gestational Age;Gestational Diabetes;Glycosylated hemoglobin A;Goals;Growth;Gynecologist;health care availability;Healthcare;healthy pregnancy;high risk;High Risk Woman;High-Risk Pregnancy;in utero;Infant;Inflammatory;innovation;Interdisciplinary Study;Interleukin-6;Intervention;Knowledge;Labor Onset;Latina;Latina Population;Life;Life Cycle Stages;Life Style;Link;Lipids;Longitudinal Studies;maternal outcome;Measures;medical complication;microbiome;modifiable risk;Mothers;Multicenter Studies;multidisciplinary;National Heart, Lung, and Blood Institute;neighborhood safety;Not Hispanic or Latino;Obesity;obstetric care;offspring;Patients;perinatal outcomes;Physiologic pulse;Physiology;post pregnancy;postnatal;postpartum care;Postpartum Period;Postpartum Women;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy hypertension;Pregnant Women;Prenatal care;prevent;Prevention;Prevention strategy;primary outcome;Primary Prevention;prospective;Proteomics;Public Health;Publishing;Pulse Rates;Questionnaires;Race;racial difference;racial diversity;Recommendation;resilience;Risk Factors;risk prediction;risk stratification;screening;sex;Sex Differences;social;Socioeconomic Status;Sports;success;Testing;Time;Vascular Diseases;Weight;Woman;Women's Health;Workplace

PROJECT_TITLE: Arterial stiffness in mother/infant dyads: Life course approach to prevent cardiovascular disease

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: AI

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative The gut-associated adaptive immune system provides crucial resistance mechanisms against enteric infections, but also represents a major regulator of the microbiota composition itself. This proposal seeks to define how antibody formation and secretion in the intestine are regulated, including the influence of the microbiome. This knowledge is relevant for a better understanding of several diseases process, ranging from inflammatory bowel diseases (IBD) to food allergy, autoimmunity and cancer.

PI_NAMEs: MUCIDA, DANIEL S;VICTORA, GABRIEL D (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Acceleration;Adaptive Immune System;adaptive immunity;Address;Affinity;Alleles;Antibodies;Antibody Affinity;Antibody Formation;Antibody Response;Antigenic Diversity;Antigens;Autoimmunity;Automobile Driving;B-Cell Antigen Receptor;B-Lymphocytes;Biochemical;Biology;Bone Marrow;Cellular biology;Clone Cells;Color;commensal microbes;Complex;Data;Digestion;dimer;Disease;enteric infection;experimental study;Food;Food Hypersensitivity;Gastrointestinal tract structure;germ free condition;Germ-Free;Gnotobiotic;gut colonization;gut microbes;gut microbiome;gut microbiota;Image;Immune response;Immune system;Immunization;Immunoglobulin A;Immunoglobulin Class Switching;Immunoglobulin Genes;Immunology;Infection;Inflammatory Bowel Diseases;insight;Intestines;Knowledge;Lamina Propria;Lymphocyte;lymphoid structures;Malignant Neoplasms;Maps;Measures;mesenteric lymph node;Microbe;microbial;Microbiology;microbiome;microbiota;microbiota composition;mouse model;Mucous Membrane;Mus;Nature;Outcome;Peyer's Patches;Physiological;Physiological Processes;Physiology;plasma cell differentiation;Plasma Cells;Play;Process;Reagent;Recombinants;Reporting;Resistance;resistance mechanism;response;Role;Secretory Immunoglobulin A;Series;single cell sequencing;Specificity;Stimulus;Structure;Structure of germinal center of lymph node;System;Techniques;tool;Work

PROJECT_TITLE: B cell clonal selection in gut-associated germinal centers

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ORG_CITY: MILWAUKEE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE We have identified a cell population expressing renin within the rostral ventrolateral medulla (RVLM), a brainstem region involved in sympathetic control. The goal of this proposal is to elucidate the requirement of the prorenin receptor for the non-hydrolytic activation of prorenin within the RVLM. We also hypothesize that conditional ablation of prorenin receptor in the RVLM attenuates the manifestation of the cardiovascular abnormalities due to brain renin angiotensin system activation.

PI_NAMEs: NAKAGAWA, PABLO  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Ablation;Acute;adenovirus mediated delivery;Affect;Anatomy;Angiotensin II;Angiotensin II Receptor;Angiotensinogen;Angiotensins;Area;Attenuated;autocrine;Binding;Blood Pressure;blood pressure control;blood pressure elevation;Brain;Brain region;Brain Stem;Calcium;Cardiovascular Abnormalities;Cardiovascular Manifestation;Cardiovascular system;Cause of Death;Cell Nucleus;Cells;Circulation;Data;Disinhibition;Dissociation;driving force;Endocrine;Enzymes;Event;Excision;Extracellular Space;Gene Deletion;Generations;Genes;Genetic;genetic approach;Goals;GTP-Binding Proteins;Heart Diseases;Hormones;Hypertension;In Vitro;in vivo;Inactive Renin;insight;Institution;Juxtaglomerular Cell;Kidney;Laboratories;Laboratory Research;Longitudinal Studies;LoxP-flanked allele;Mediating;Metabolic Control;Microinjections;Modeling;Molecular;Molecular Profiling;Mus;Myocardial Infarction;Nerve;neurogenic hypertension;Neurons;normotensive;novel;Organ;paracrine;Peptides;Physiological;Play;Population;prevent;prorenin receptor;Protein Isoforms;Reactive Oxygen Species;receptor;Receptor Activation;receptor binding;Receptor Signaling;Receptor, Angiotensin, Type 1;Recombinants;release of sequestered calcium ion into cytoplasm;Renal Tissue;Renin;Renin-Angiotensin System;Research;response;Risk Factors;Role;Scientific Advances and Accomplishments;Scientist;Secretory Vesicles;Sensitivity and Specificity;sensor;Signal Transduction;Signaling Protein;single nucleus RNA-sequencing;skills;Stroke;System;Techniques;Testing;Tissues;tool;Training;transcriptomics;Transgenic Mice;Translations;United States

PROJECT_TITLE: Role of the prorenin receptor in blood pressure and autonomic control through the local activation of the renin angiotensin system in the brainstem


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Heart Disease;Liver Disease;Nutrition;Substance Misuse

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Alcohol metabolism may reduce the cellular energy state in the heart, which can alter cardiac function. The following proposal will make meaningful advancements in our understanding of the effects chronic alcohol consumption and abuse has on metabolic function in the heart and liver. This project will also investigate novel mechanisms that when impaired, or ablated, may mitigate the alcohol induced alterations in the cardiac energy state.

PI_NAMEs: FLETCHER, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Ablation;Acetaldehyde;Acetate-CoA Ligase;Acetates;Acetyl Coenzyme A;Acute;Affect;Agreement;Alcohol abuse;Alcohol consumption;Alcohol dehydrogenase;alcohol effect;alcohol response;Alcoholic Cardiomyopathy;Alcoholic Fatty Liver;Alcohols;aldehyde dehydrogenases;ATP phosphohydrolase;Biochemical Reaction;Blood Pressure;Cardiac;Cardiac health;Cardiac Myocytes;Cardiovascular Diseases;Chronic;chronic alcohol ingestion;Circulation;Cirrhosis;Citric Acid Cycle;Consumption;Cytosol;Data;Development;Diet;dietary control;Doctor of Medicine;Doctor of Philosophy;Dose;Drug usage;Echocardiography;Educational process of instructing;EFRAC;Enzymes;Ethanol;Ethanol Metabolism;experimental study;fatty acid oxidation;fatty liver disease;Functional disorder;Future;Heart;Heart Diseases;Heart failure;heart function;heart metabolism;Hepatic;Human;Hyperlipidemia;Hypertension;Impairment;In Vitro;in vivo;Infusion procedures;insight;Knock-out;Knockout Mice;Learning;lipid biosynthesis;Lipids;Liquid substance;Liver;Liver Cirrhosis;Malonyl Coenzyme A;Mediating;Metabolic;metabolic abnormality assessment;Metabolism;metabolomics;Mitochondria;Mus;Myocardial dysfunction;NADH;Nonesterified Fatty Acids;novel;Organ;oxidation;Oxidation-Reduction;Perfusion;Peripheral;Predisposition;Process;Production;Protein Isoforms;Protocols documentation;response;Rodent;Role;skills;Techniques;Tissues;Tracer;Training;Triglycerides;United States;Wild Type Mouse

PROJECT_TITLE: The effects of alcohol metabolism on hepatic and cardiac energy state and function

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Impact. Our collaborative team brings complementary research expertise and the successful completion of the project will create a resource that fills critical diabetes knowledge gaps. This proposal represents a unique and ideally-timed opportunity to study the genetic signature of pancreas organization at unprecedented chromatin, transcriptomic, cellular, and disease-state scales. Our results have the potential to identify associations between chromatin architecture and tissue organization, define the cell- and context-specific regulatory elements and genes that influence these effects, and discover the cellular neighborhoods in which they are active. This proposal represents an approach that can be applied across other diseases and traits with GWAS data.

PI_NAMEs: BRISSOVA, MARCELA ;LIU, JIE ;PARKER, STEPHEN CJ (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Acinar Cell;Adult;Age;Alpha Cell;American;Architecture;Beta Cell;Biological;Biology;Cell Differentiation process;Cell Nucleus;cell type;Cells;centralized portal;Chromatin;Complex;Computer Analysis;Data;Data Analyses;data sharing;Development;Diabetes Mellitus;diabetes risk;Diagnosis;Dimensions;Disease;Ductal Epithelial Cell;Elements;Endocrine;Enhancers;Environmental Risk Factor;epigenomics;Ethnic Population;functional genomics;Genes;Genetic;Genetic Predisposition to Disease;genetic signature;Genetic study;genome wide association study;Genomic approach;Genotype;Glucose;Growth;Heritability;Heterogeneity;Hormone secretion;Human;Image;In Situ;in situ imaging;Individual;Inflammation;insight;Insulin;Interdisciplinary Study;islet;Islets of Langerhans;Knowledge;Location;Machine Learning;Macrophage;Maps;Measures;Medical Care Costs;Molecular;Molecular Analysis;multi-ethnic;multimodality;multiple omics;Natural regeneration;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;Organ;Pancreas;Pattern;personalized therapeutic;Physiological;Physiology;Play;Prediabetes syndrome;Process;Proteomics;Quantitative Trait Loci;Regulator Genes;Regulatory Element;Research;Resolution;Resources;RNA;Role;sex;Signal Transduction;single cell genomics;Single Nucleotide Polymorphism;Specificity;Technology;Text;Tissue imaging;Tissues;tool;trait;Transcriptional Regulation;transcriptome;transcriptomics;Translating;Untranslated RNA;Weight;XCL1 gene

PROJECT_TITLE: Multi-omic genetic regulatory signatures underlying tissue complexity of diabetes in the pancreas at single-cell spatial resolution

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: TUSKEGEE INSTITUTE

ORG_NAME: TUSKEGEE UNIVERSITY

ORG_STATE: AL

PHR: OVERALL: PROJECT NARRATIVE: This type 2 U54 application is derived from the existing, productive Partnership between Morehouse School of Medicine (MSM), Tuskegee University (TU), and the O’Neal Comprehensive Cancer Center (OCCC) at UAB, which is committed to the elimination of cancer health disparities in racial/ethnic minority and underserved populations in the ‘Deep South,’ particularly among African Americans. By leveraging the distinct yet complementary strengths and resources of this Partnership, rigorous and collaborative transdisciplinary research that encompasses basic biologic, preclinical, educational, behavioral, social, and community-based programs leads to evidence-based solutions and an understanding of the causes of cancer health disparities.

PI_NAMEs: MANNE, UPENDER ;RIVERS, BRIAN M.;TURNER, TIMOTHY  (contact)

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TERMS: Acceleration;Address;Adherence;African American;African American population;Alabama;anti-cancer research;Applications Grants;Award;Basic Science;Behavioral;Behavioral Research;Bioethics;Bioinformatics;Bioinformatics Shared Resource;Biological;biological research;Biometry;Biotechnology;Cancer Biology;Cancer Burden;cancer care;Cancer Center Planning Grant;Cancer Control;cancer education;Cancer Etiology;cancer genomics;cancer health disparity;Cancer Research Project;cancer risk;career;Clinical;Clinical Cancer Center;Clinical Research;Clinical Trials;Collaborations;Colorectal Cancer;colorectal cancer screening;Combined Modality Therapy;Communities;community involvement;Complement;Comprehensive Cancer Center;Deep South;Development;dietary;Education;education research;Educational Curriculum;Enrollment;Ensure;Ethics;ethnic minority;Ethnic Population;Evaluation;evidence base;Extramural Activities;Faculty;Foundations;Funding;Goals;graduate student;Grant;Health Disparities Research;health disparity;Healthcare Systems;healthy lifestyle;Heart;high school;Hospitals;immunomodulatory strategy;improved;Institution;Intervention;laboratory experience;Latinx;Link;lung cancer screening;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;Medical;Medical Students;member;Methods;Minority Groups;minority investigator;minority student;Minority-Serving Institution;Modeling;Morehouse School of Medicine;multidisciplinary;NCI-Designated Cancer Center;next generation;Outcome;outreach;outreach program;overexpression;Patients;Peer Review;personalized medicine;Physical activity;Pilot Projects;Policies;Population Sciences;Postdoctoral Fellow;pre-clinical;pre-clinical research;Productivity;programs;Provider;Public Health Informatics;Publications;Publishing;racial disparity;racial minority;recruit;Research;research and development;research faculty;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk Reduction;rural dwellers;Scientist;Secure;social;success;summer research;symposium;System;Testing;theories;Therapeutic Trials;traditional care;Training;Training Programs;tumor-immune system interactions;twelfth grade;undergraduate student;underserved area;Underserved Population;Universities;uptake;Vision

PROJECT_TITLE: 2/3 Morehouse School of Medicine/Tuskegee University/ University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: TURNER, TIMOTHY  (contact)

PROJECT_TERMS: Administrative Efficiency;Advisory Committees;Alabama;Applications Grants;Area;Bioethics;Bioinformatics;Biometry;Budgets;cancer health disparity;clinical center;Clinical Sciences;Collaborations;Communication;Comprehensive Cancer Center;Data;data management;data sharing;Disparity population;education research;Ensure;Evaluation;experience;Funding;Goals;Human Resources;Infrastructure;Institution;Joints;Leadership;Lilium;Logistics;meetings;member;Minority Groups;minority health;minority health disparity;Monitor;Morehouse School of Medicine;Office of Administrative Management;outreach;Pilot Projects;Policies;Preparation;Principal Investigator;Productivity;Program Evaluation;programs;Progress Reports;Regulation;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Review Committee;Rice;Science;Services;Supervision;symposium;Teleconferences;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE The goal of this project is to establish a Tissue Mapping Center to identify and characterize senescent cells in murine liver, adipose, skeletal muscle, lung, and brain tissues across the lifespan of wild-type mice in two genetic backgrounds as part of the SenNet Consortium. The collective goal of SenNet is to develop a 4D atlas of senescent cells in humans using mice to inform and validate that map.

PI_NAMEs: BUDINGER, GR SCOTT ;KHOSLA, SUNDEEP ;ROBBINS, PAUL D. (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Ablation;Acceleration;Adipose tissue;age-related disease;aged;Aging;aging population;Alzheimer's Disease;Architecture;Atlases;Attenuated;Award;Bioinformatics;Biological;Biological Markers;Biological Process;Biology;biomarker identification;Birth;Brain;brain tissue;Cell Aging;Cells;Cellular biology;Chromatin;Clinic;Clinical Trials;Collaborations;Collection;Communication;Communities;Complex;Data;Data Analyses;Data Collection;Data Coordinating Center;Data Discovery;data management;data modeling;Data Science;Data Set;data sharing;Detection;Development;digital;Disease;Disparate;DNA Methylation;Embryonic Development;Equipment;Evolution;Excision;experience;extracellular;FAIR principles;frailty;Gene Expression;Generations;Genetic;Genome;Genomics;Goals;Human;Human Resources;Image;Immune system;Immunology;Immunotherapy;improved;Informatics;Infrastructure;innovation;Institution;International;Knowledge;Label;Lead;Learning;life span;Link;Liver;Location;Lung;Maps;Measurement;Measures;member;Metadata;Midwestern United States;Minnesota;Modeling;Molecular;mouse model;Multiplexed Ion Beam Imaging;Mus;Muscle;nano-string;novel;old mice;Organ;Organism;Pathologic;Pathology;Pharmaceutical Preparations;pharmacologic;Phenotype;phenotypic biomarker;Physiological;Physiology;Play;Procedures;Production;Proteomics;quality assurance;Quality Control;Reagent;Recording of previous events;Research;Research Personnel;resilience;response;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;single cell analysis;skeletal tissue;stressor;Structure of parenchyma of lung;success;synergism;Technology;technology development;Time;tissue mapping;Tissue Sample;Tissues;Transgenic Animals;Transgenic Mice;Tumor Suppression;United States National Institutes of Health;Universities;Visualization;Visualization software;Wild Type Mouse;Work;wound healing

PROJECT_TITLE: Midwest Murine-Tissue Mapping Center (MM-TMC)


NIH_SPENDING_CATS: Aging;Biotechnology

PI_NAMEs: BERNLOHR, DAVID A (contact)

PROJECT_TERMS: Adherence;Adipose tissue;Adoption;Aging;analytical tool;Animals;Atlases;Bacterial Artificial Chromosomes;Basic Science;Biochemistry;Biology;Biology of Aging;biomarker discovery;Biophysics;bone;Brain;career;Cell Aging;Cells;Cellular biology;Clinic;Collaborations;Common Data Element;Communication;Communities;Critical Care;Data;Data Analyses;Data Collection;Data Coordinating Center;data exchange;data integration;Data Set;data sharing;data standards;data submission;data visualization;Development;Development Plans;Dimensions;Emerging Technologies;Ensure;Evaluation;experience;Experimental Designs;Funding;Future;Gene Expression Profiling;Generations;Goals;Grant;Head;Histology;Home;Human;human tissue;IACUC;Immunology;innovation;Interdisciplinary Study;International;Knowledge;Laboratories;Leadership;Lipids;Liver;Lung;Management Information Systems;Maps;medical schools;meetings;Metabolic;metadata standards;Methods;Midwestern United States;Minnesota;Molecular Biology;mouse model;Mus;Muscle;nano-string;novel strategies;Obesity;operation;Osteoporosis;oxidized lipid;Paper;Pathology;pharmacologic;Phenotype;Pilot Projects;Procedures;Productivity;programs;Protocols documentation;Readiness;Reporting;Reproducibility;Research;Research Personnel;Role;Sampling;senescence;senescent cell;Signal Transduction;single cell analysis;Site;Software Tools;Technology;technology development;Testing;tissue mapping;Tissues;tool;Training;Training Activity;Transfer Agreement;Transgenic Mice;United States National Institutes of Health;Universities;Validation;Visualization;Visualization software;webinar;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-M]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Genetics

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Due to its unique advantages as an experimental system, Xenopus has for many years revealed key insights into multiple domains of biomedical science including cell biology, embryology, neurobiology, physiology and signal transduction. This proposal seeks to characterize Xenopus at the very deep level of single cell RNA expression in embryonic development through to adult organs, so that it may serve as a better model for the causes and therapies for human disease.

PI_NAMEs: PESHKIN, LEON  (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Adopted;Adult;Amphibia;Animal Model;Atlases;Benchmarking;Biological;Biological Metamorphosis;Biological Models;biological systems;Biomedical Research;Body System;Brain;Cell Cycle;Cell Nucleus;Cell Size;cell type;Cells;Cellular biology;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;combinatorial;Communication;Communities;Complement;Cyclins;Data;Data Set;data sharing;Destinations;Development;Disease;disease model;Dissociation;Embryo;embryo cell;Embryology;Embryonic Development;Evolution;experience;experimental study;Extracellular Matrix;Funding;gastrulation;Gene Expression Profiling;gene function;gene interaction;Genes;Genetic;Genetic Transcription;Heart;Human;human disease;human genomics;Immune system;Individual;Infrastructure;innovation;insight;International;Investigation;Kidney;Laboratories;Learning;Left;Link;malformation;marine;meetings;Methods;model organism;Modeling;Molecular;Mus;mutant;Natural regeneration;Neurobiology;Nuclear;nuclear reprogramming;Organ;Organism;Organogenesis;Physiological;Physiology;Play;Procedures;Process;Proteins;Proteomics;Protocols documentation;Publishing;Research;Research Personnel;Research Project Grants;Resolution;Resources;Rest;Sampling;Science;Scientist;Signal Transduction;single cell analysis;Specialist;Specific qualifier value;System;therapeutic evaluation;Time;Tissue atlas;Tissues;tool;transcriptomics;United States National Institutes of Health;web portal;Work;XenBase;Xenopus;Zebrafish

PROJECT_TITLE: XenCAT: Xenopus Single Cell Atlas


NIH_SPENDING_CATS: Cancer;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: WEBB, LECARDE  (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Advisory Committees;Alabama;anti-cancer research;Behavioral;Bioethics;Bioinformatics Shared Resource;Biometry;cancer education;cancer genomics;cancer health disparity;clinical trial enrollment;Clinical Trials;Communities;Community Healthcare;Community Outreach;Complex;Comprehensive Cancer Center;Data Collection;Development;Education;education research;ethnic minority;Evaluation;Event;evidence base;Evidence based program;experience;Feedback;Funding;Future;Goals;health care settings;high school;Impact evaluation;innovation;Institution;Joints;Leadership;Link;Logic;Malignant Neoplasms;Medical Students;meetings;Methods;Modeling;Molecular;Morehouse School of Medicine;Nature;Organizational Change;Outcome;Output;outreach program;Pilot Projects;Postdoctoral Fellow;Principal Investigator;Process;process evaluation;programs;racial minority;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Responsible Person;Rivers;Rural Community;Scientist;sound;synergism;theories;timeline;tool;Translating;Translational Research;undergraduate student;Universities;Urban Community;Work;Writing

PROJECT_TITLE: Planning and Evaluation Core


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics

PI_NAMEs: LEBRASSEUR, NATHAN K (contact)

PROJECT_TERMS: 3 year old;Ablation;Adipocytes;Adipose tissue;Age;aged;Aging;Amino Acid Sequence;analytical tool;Animals;Architecture;Astrocytes;Atlases;Attenuated;Automobile Driving;Biological;Biological Assay;Biological Markers;Biological Models;Biology;biomarker discovery;Birth;Brain;brain tissue;CDKN2A gene;Cell Aging;cell killing;cell preparation;cell type;Cells;Chromatin;Chronic Disease;Clinic;Collaborations;Cre driver;cytokine;Data;Data Analyses;Data Set;Detection;detection assay;Development;digital;Disease;Electronic Health Record;Emerging Technologies;Ensure;Epigenetic Process;Evolution;experience;frailty;Funding;Gene Expression;Generations;Genes;Genetic;Genome;Genomics;Goals;healthspan;Hepatocyte;Heterogeneity;Human;Hybrids;Image;imaging facilities;improved;in vivo;Inbreeding;Infrastructure;innovation;instrumentation;Ions;Laboratories;life span;Liver;Lung;Management Information Systems;Manuscripts;Maps;Mass Spectrum Analysis;member;Methodology;Methods;Microglia;Midwestern United States;Minnesota;model organism;Modeling;Morbidity - disease rate;mortality;Mouse Strains;Mus;Muscle;Muscle Cells;nano-string;Neurons;new technology;novel;Organ;Pathology;Pattern;Pharmaceutical Preparations;Phenotype;Physiology;Population;preservation;progenitor;promote resilience;proteogenomics;Proteomics;Publishing;Quality Control;Reporting;Reproducibility;Resources;Role;Sampling Errors;scale up;Scientist;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Sensitivity and Specificity;single-cell RNA sequencing;Site;Skeletal Muscle;skeletal tissue;spatiotemporal;Structure of parenchyma of lung;Supercomputing;Technology;therapeutic target;Time;Tissue atlas;Tissue Banks;tissue mapping;Tissue Sample;Tissues;tool;transcriptomics;Transgenic Mice;Universities;Wild Type Mouse;wound healing

PROJECT_TITLE: Biological Analysis Core


NIH_SPENDING_CATS: Aging;Cancer;Cervical Cancer;Clinical Research;Cost Effectiveness Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Although cervical cancer screening has been successful in the United States, little is known about the optimal circumstances under which screening can safely end. Here, we address this research gap by estimating cervical cancer screening benefits and harms after age 65 in a large group of women enrolled in two large integrated healthcare systems in California. Results will help improve ways to provide cervical cancer screening to older women.

PI_NAMEs: SAWAYA, GEORGE F (contact);SILVERBERG, MICHAEL J

PROGRAM_OFFICER_NAME: KOBRIN, SARAH

PROJECT_TERMS: Address;Adoption;Age;Aging;American Cancer Society;Area;Biometry;California;cancer diagnosis;cancer epidemiology;cancer risk;Cervical;cervical cancer prevention;Cervical Cancer Screening;Cervix Uteri;Cessation of life;clinically significant;Cohort Studies;Communicable Diseases;Cost Effectiveness Analysis;Cytology;Data;Decision Modeling;Diagnostic Procedure;Discipline of obstetrics;Effectiveness;Electronic Health Record;Enrollment;Equilibrium;evidence base;experience;Future;Geriatrics;Guidelines;Gynecology;Health system;high risk;HPV positive;HPV-High Risk;human old age (65+);Human Papillomavirus;Hysterectomy;improved;Incidence;Influentials;Integrated Health Care Systems;Interview;Knowledge;Life Expectancy;Malignant neoplasm of cervix uteri;Malignant Neoplasms;medical complication;member;Methods;Modeling;mortality;Older Population;older women;Operative Surgical Procedures;Outcome;Patients;Population;Procedures;Process;psychologic;Public Health;Quality-Adjusted Life Years;randomized trial;Recommendation;Recording of previous events;Research;Risk;Sampling;screening;Screening for cancer;screening guidelines;secondary analysis;Stable Populations;Stage at Diagnosis;success;Test Result;Testing;United States;United States Preventative Services Task Force;Unnecessary Procedures;Validation;Woman;Women's Group;Women's mortality;women's outcomes;Women's study

PROJECT_TITLE: Cervical cancer screening after age 65 in the era of HPV testing: estimating benefits and harms of screening cessation and continuation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-L(90)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: WANG, JINHUA  (contact)

PROJECT_TERMS: Adipose tissue;Age;analysis pipeline;analytical tool;Animals;Atlases;Benchmarking;Bioinformatics;Biologic Characteristic;Biological;Biological Assay;Biological Markers;biomarker discovery;biomarker selection;causal model;cell type;Cells;cellular imaging;Center Core Grants;Clinic;Collaborations;Common Data Element;comparative genomics;Computer Models;computing resources;Custom;Data;Data Analyses;Data Analytics;Data Commons;Data Coordinating Center;Data Element;data ingestion;data management;data portal;data quality;Data Set;data sharing;data sharing networks;Data Storage and Retrieval;data tools;data visualization;data warehouse;deep neural network;Development;Elements;Ensure;Equipment;Factor Analysis;Faculty;Generations;Genes;Genetic Markers;Genome;Genomics;Goals;graphical user interface;Guidelines;Heterogeneity;high dimensionality;High Performance Computing;Histology;Human;Human BioMolecular Atlas Program;human data;human tissue;Image;imaging Segmentation;Informatics;Ingestion;innovation;Institution;interoperability;Joints;Link;Liver;Lung;Maps;Measures;metabolomics;Metadata;metadata standards;Methods;Midwestern United States;Minnesota;Modality;Modeling;Molecular;multimodal data;multimodality;Multiomic Data;multiple omics;Mus;Neural Network Simulation;novel;novel marker;Online Systems;Ontology;Pathway interactions;Pattern;Policies;predictive modeling;Preparation;Procedures;Process;Productivity;proteogenomics;Proteomics;Protocols documentation;quality assurance;Quality Control;Recommendation;Reproducibility;Research;Research Personnel;Resources;Retrieval;Sampling;Secure;Security;senescence;senescent cell;Skeletal Muscle;Software Tools;Stains;synergism;System;Systems Biology;Testing;tissue mapping;Tissue Sample;Tissues;tool;tool development;transcriptome;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Universities;usability;user-friendly;Validation;Visualization software;Work

PROJECT_TITLE: Data Analysis Core


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Lung;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: Loma Linda

ORG_DEPT: PEDIATRICS

ORG_NAME: LOMA LINDA UNIVERSITY

PHR: Project narrative Sensory interoceptive nerves that inform the brainstem of mechanical and chemical changes in the lung are critical for normal pulmonary function and mitigation of microbial invasion. Little is known about how this interroception matures alongside lung development in the fetus, or the extent to which it may influence pulmonary development. By characterizing the necessity of pulmonary interroception for normal lung development, this project will gather crucial foundational information to advance our understanding of pulmonary diseases that originate during fetal and newborn life.

PI_NAMEs: BLOOD, ARLIN B (contact);WILSON, CHRISTOPHER G

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TERMS: Acute;Address;Adult;Affect;afferent nerve;airway epithelium;Allergic;Alveolar;Alveolus;Animals;Apnea;Asthma;Autonomic nervous system;Behavioral;Bilateral;Birth;Blood;Blood Vessels;Brain;Brain Stem;Breathing;Bronchopulmonary Dysplasia;C Fiber;Categories;Cell Nucleus;Central Nervous System;Cerebral cortex;Cesarean section;Chemicals;Chronic;Communication;Computer software;course development;Custom;Data;Denervation;Development;Dyes;Efferent Neurons;Electrodes;Embryo;Environment;environmental stressor;Epithelium;Esthesia;Exercise;experience;Feedback;fetal;Fetal Development;Fetal Lung;Fetal Sheep;Fetus;fetus hypoxia;Future;Gases;Goals;Growth;Growth and Development function;Human;human model;Hypoxia;Immune response;Implant;instrument;Interoception;Invaded;Irritants;Knowledge;Life;Link;Location;loss of function;Lung;lung development;Lung Diseases;Maintenance;Maps;Measures;Mechanics;Mechanoreceptors;methacholine;microbial;Modeling;Modernization;Monitor;Morphology;Myography;Nature;Nerve;nerve supply;nervous system development;neural;neural circuit;neural network;Neurobiology;Neuroendocrine Cell;Neuroimmune;Neurons;neuroregulation;neurotransmission;Newborn Infant;Nodose Ganglion;novel;Operative Surgical Procedures;Organ;Outcome Study;pathogen;Pattern;Perinatal;Periodicals;Periodicity;Phase;Phenotype;Physiology;Play;Population;postnatal;Pregnancy;premature;Prevalence;Pulmonary artery structure;pulmonary function;Pulmonary Gas Exchange;receptor;Research;Respiration;respiratory;Respiratory physiology;response;Role;Sensory;Series;Sheep;sheep model;Signal Transduction;Stress;Structure;Sudden infant death syndrome;Synapses;Techniques;Testing;Thinness;Time;Tissues;Tracer;transcriptome sequencing;Vagus nerve structure;Viral;Work

PROJECT_TITLE: Unravelling lung interoception and its functional consequence in the developing ovine lung


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Behavioral and Social Science;Burden of Illness;Caregiving Research;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Mental Health;Palliative Care;Patient Safety;Rare Diseases;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Financial hardship is common, persistent and a major source of stress for patients with acute respiratory failure, a common critical illness that is associated with prolonged disability and high risk of death. This longitudinal cohort study across two large and diverse health systems will advance our understanding of the factors that contribute to financial hardship, and the impact of financial hardship, for seriously ill adults with acute respiratory failure and their family caregivers. Using survey and electronic health data, longitudinal mediation analyses and semi-structured interviews, our results will inform the development of context-specific interventions designed to mitigate financial hardship and improve patient- and family-centered outcomes for this critically ill population and their family.

PI_NAMEs: KHANDELWAL, NITA  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute respiratory failure;Address;Adult;Age;Behavioral;Caregiver Burden;Caregivers;Caring;Characteristics;Chronic;Clinical;cognitive disability;Coping Behavior;coping mechanism;Critical Illness;Data Collection;Deterioration;Development;disability risk;effective intervention;electronic health data;Electronic Health Record;emotional distress;Enrollment;Ethnic Origin;Evaluation;experience;Family;Family Caregiver;Family Characteristics;Family member;Financial Hardship;financial literacy;Future;Goals;Health;health literacy;health related quality of life;Health Surveys;Health system;Healthcare Systems;high risk;Hospitalization;Hospitals;improved;Individual;instrument;Intervention;Interview;Knowledge;Life;Longitudinal cohort study;loved ones;low health literacy;Malignant Neoplasms;Measures;Mediation;Mediator;meetings;Methods;Morbidity - disease rate;mortality risk;multidisciplinary;Oncology;Outcome;Outpatients;palliative;Participant;Patients;Perception;physically handicapped;Policies;Population;preference;psychologic;psychological distress;psychological outcomes;Qualitative Methods;Qualitative Research;Quality of life;Race;racial minority;Reporting;Resources;response;Risk;Risk Factors;Role;Sampling;Social support;sociodemographics;Source;Stress;Structure;Surveys;Survivors;therapy design;therapy development;Time;Training;trial design;Underinsured;Unemployment;Uninsured Medical Expense;Vulnerable Populations;Work

PROJECT_TITLE: Financial Hardship among Patients with Acute Respiratory Failure and their Family Member Caregivers: Understanding the Impact on Patient- and Family- Centered Outcomes

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prostate Cancer;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Urologic Diseases

PI_NAMEs: WANG, HONGHE  (contact)

PROJECT_TERMS: African American;African American population;Age;Alabama;anti-cancer research;Aptitude;Biomedical Research;cancer education;cancer health disparity;Cancer Research Project;cancer therapy;cancer type;career;career development;Career Mobility;Caring;Clinical Research;college;Colorectal Cancer;Communication;Communities;Comprehensive Cancer Center;Death Rate;Diagnosis;Diverse Workforce;Education;education research;Educational Activities;Educational Curriculum;ethnic disparity;ethnic diversity;ethnic minority;Evaluation;experience;Exposure to;Faculty;Feedback;Fellowship;Funding;Future;Goals;graduate school;graduate student;Grant;hands on research;Health;Health Disparities Research;Healthcare;high school;High School Student;Immersion;improved;Incidence;Informatics;Infrastructure;Institution;interest;Interview;Joints;Laboratories;Latinx;Learning;Link;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;medical schools;Medical Students;member;men;Mentors;Methods;Minority Groups;Morehouse School of Medicine;mortality;Movement;Outcome;outreach;Patients;Policies;Postdoctoral Fellow;Productivity;programs;Publications;racial disparity;racial diversity;racial minority;recruit;Research;Research Personnel;Research Project Grants;response;rural area;rural setting;Science;Scientist;skills;social media;statistics;Structure;Students;summer program;Training;undergraduate student;Underrepresented Minority;underserved minority;United States National Institutes of Health;Universities;urban area;urban setting

PROJECT_TITLE: Research Education Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Data Science;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Rare Diseases;Tuberculosis

ORG_CITY: BAMAKO

ORG_COUNTRY: MALI

ORG_FIPS: ML

ORG_NAME: UNIV OF SCIENCES, TECH & TECH OF BAMAKO

PHR: Project Narrative Innovative public health research, such as data science approaches are critical to address challenges related to the burden of communicable and noncommunicable in Sub-Saharan African countries. However, there is limited human resources with skills and expertise in data sciences to harness the value of a breadth of diverse, large, and complex clinical and biomedical data sets generated through an increasing international partnership. This UE5 proposal will build interdisciplinary teams across multiple institutions capable of using innovative quantitative and analytical approaches to generate and apply new knowledge from large or complex sets of data in the subregion. The proposal will strengthen existing institutional research training programs to address the needs for optimal use and processing of large and complex data sets using advanced data science approaches. It will facilitate partnership among researchers and local faculty and stakeholders for future implementation of data sciences research.

PI_NAMEs: DOUMBIA, SEYDOU  (contact);SHAFFER, JEFFREY G

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Address;Affect;Africa;Africa South of the Sahara;African;Area;Big Data;Bioinformatics;Biomedical Research;Cardiovascular Diseases;Clinical;Clinical Research;Collaborations;Communicable Diseases;Complex;complex data;Country;course sequence;Data;Data Analyses;Data Engineering;Data Science;Data Set;Data Sources;Development;Diabetes Mellitus;Diagnosis;Disease;Disease Outcome;disorder control;Doctor of Philosophy;education research;Educational Curriculum;Emerging Communicable Diseases;emerging tropical infectious disease;experience;Faculty;faculty research;Fogarty International Center;future implementation;Goals;Guinea;hackathon;Health Professional;HIV/AIDS;HIV/TB;Human Resources;infectious disease model;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;international center;international partnership;Intervention;Knowledge;learning materials;Life;Machine Learning;Malaria;Mali;Malignant Neoplasms;Master of Science;Medical;National Institute of Allergy and Infectious Disease;neglected tropical diseases;neurogenetics;next generation;Parasitic Diseases;Participant;Positioning Attribute;programs;Public Health;Public Health Education;public health research;rapid growth;Research;Research Ethics;Research Personnel;Research Project Grants;Research Training;Resources;response;Science;Scientist;Sickle Cell Anemia;skills;spatial epidemiology;technology/technique;Training;Training Programs;Tuberculosis;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: West Africa Center of Excellence for Data Science Research Education


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Mitochondria are endosymbiotic organelles that have their own genome and perform many essential functions in eukaryotic cells, including ATP synthesis via oxidative phosphorylation. Mitochondrial DNA (mtDNA) mutations cause heritable respiratory chain deficiency and contribute to a wide spectrum of diseases in humans, including metabolic disease, neurodegeneration, and cancer. The proposed research will define how mtDNA synthesis is regulated at the chromosome, organelle and cellular levels in physiologically relevant cellular and invertebrate models, and how disruption of these processes impinges on mtDNA integrity, cellular homeostasis, and ultimately human health. This work is relevant to the part of the NIH's mission that fosters fundamental basic cell biology discoveries that will directly lead to the identification of new therapeutic targets and therapies for the treatment of a wide array of human diseases.

PI_NAMEs: LEWIS, SAMANTHA C (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Alleles;Animals;ATP Synthesis Pathway;Biology;Cell Physiology;Cells;Cellular biology;Chromosomes;Complex;Disease;Eukaryotic Cell;experimental study;Fostering;Genetic Transcription;Genome;Goals;Health;Heritability;Homeostasis;Human;human disease;insight;Invertebrates;Literature;Maintenance;Malignant Neoplasms;Metabolic Diseases;Microscopy;Mission;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial dysfunction;mitochondrial genome;Mitochondrial Respiratory Chain Deficiencies;Modeling;Molecular;mutant;Nerve Degeneration;new therapeutic target;novel;Organelles;Oxidative Phosphorylation;Pathway interactions;Physiological;Process;Proteins;Proteomics;Research;RNA;segregation;Somatic Cell;Systems Analysis;Tissues;United States National Institutes of Health;Work

PROJECT_TITLE: Systems analysis of mitochondrial genome maintenance in physiological context

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: CARTER, VIVIAN L (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;African American;African American population;Alabama;anti-cancer research;Attitude;Awareness;Behavior;Belief;Biomedical Research;cancer clinical trial;cancer genomics;cancer health disparity;Cancer health equity;Cancer Patient;cancer prevention;cancer risk;cancer therapy;Catchment Area;Clinical;Clinical Research;clinical trial enrollment;Clinical Trials;Communities;Community Health;Comprehensive Cancer Center;design;Disease;Early Diagnosis;Education;education resources;Environment;Equity;Evaluation;evidence base;Genetic;Genomics;Goals;health disparity populations;Institution;interest;Joints;Knowledge;Latinx;Latinx population;Logic;Malignant Neoplasms;Medicine;Minority Participation;Modeling;Morehouse School of Medicine;National Cancer Institute;Outcome;Outcome Measure;outreach;Participant;patient navigation;Population;Population Heterogeneity;precision oncology;preference;Prevention;Privacy;programs;recruit;Research;Research Project Grants;research study;Resources;Rural Community;Safety;Scientific Advances and Accomplishments;Services;Standardization;Surveys;Tablets;Technology;theories;Therapeutic Clinical Trial;Training;Trust;Underserved Population;United States National Institutes of Health;Universities;Urban Community

PROJECT_TITLE: Outreach Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Coronaviruses;Genetics;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: TEMPE

ORG_DEPT: PHYSICS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Understanding the biological impact of protein amino acid changes is important for personalized medicine, protein engineering, and understanding viral evolution. However, among the vast space of possible mutations, the important ones that modify function and/or are associated with disease cannot yet be reliably predicted. We will use an integrative experimental and computational approach to identify improved biophysical “rules” that will be instrumental for advanced computer predictions.

PI_NAMEs: OZKAN, SEFIKA BANU (contact);SWINT-KRUSE, LISKIN

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Affinity;Algorithms;Amino Acid Substitution;Amino Acids;Automobile Driving;Binding;Binding Sites;Biological;Biophysics;Collaborations;combinatorial;Computer Models;computerized tools;Computers;Coupled;Coupling;Cyclic AMP Receptor Protein;Data;Development;Disease;Distal;DNA Binding;Equilibrium;Escherichia coli;Event;Evolution;Exhibits;experimental study;flexibility;functional outcomes;Genetic Epistasis;Genetic Variation;Goals;Homologous Protein;Human Genetics;Impairment;improved;Lactose;Ligand Binding;Ligands;Machine Learning;Measures;Medicine;Methods;Missense Mutation;Modeling;Molecular;molecular dynamics;Molecular Genetics;molecular modeling;Motion;Mutation;network models;novel;Open Reading Frames;Outcome;outcome prediction;personalized medicine;Phenotype;Positioning Attribute;predictive modeling;predictive tools;Property;Protein Dynamics;Protein Engineering;protein function;Proteins;Publishing;Recording of previous events;Repressor Proteins;Research;response;Rest;Sampling;SARS-CoV-2 protease;Site;Specificity;structural biology;success;System;Technology;Testing;Variant;Viral;Viral Proteins

PROJECT_TITLE: Using dynamic network models to quantitatively predict changes in binding affinity/specificity that arise from long-range amino acid substitutions

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Neural injury or degeneration causes huge financial and emotional burdens to patients and their caregivers in the US. No effective cure exists due to the permanent loss of neurons. The proposed project will define an innovative way to convert non-neuronal cells into neurons for functional repair by using a patient’s own cells without transplantation.

PI_NAMEs: ZHANG, CHUN-LI  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Adult;Animals;Astrocytes;axon growth;axon regeneration;Behavioral;Biological Process;Brain;Caregivers;Cell Physiology;Cell Proliferation;Cell Transplantation;cell type;Cells;Central Nervous System;Chemicals;Cicatrix;Clinical;clinical translation;clinically relevant;CSPG4 gene;Data;Emotional;Failure;Gene Modified;Genetic;Glial Cell Proliferation;Goals;Human;Immune;improved;In Vitro;in vivo;Induced Neurons;inhibitor;Injury;injury recovery;innovation;Lentivirus;Lesion;model organism;Molecular;mouse model;Mus;Natural regeneration;Nerve Degeneration;nerve injury;Nerve Regeneration;nerve stem cell;neural circuit;neural repair;neuroblast;Neurodegenerative Disorders;neurogenesis;Neuroglia;neuroinflammation;neuron loss;neuronal excitability;neuronal survival;Neurons;Outcome;patch clamp;Pathologic;Patients;Play;Population;postsynaptic;presynaptic;Process;programs;Proliferating;promoter;Rabies virus;Recombinants;Recovery of Function;regenerative approach;repaired;Research;response to injury;Role;single nucleus RNA-sequencing;Site;Spinal Cord;Spinal cord injury;stem cells;Synapses;Therapeutic;Tissue Preservation;Transplantation;tumorigenesis;Undifferentiated;Vesicular stomatitis Indiana virus;Work

PROJECT_TITLE: In Vivo Reprogramming of NG2 Glia for Neurogenesis

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: SODEKE, STEPHEN O (contact)

PROJECT_TERMS: Address;Advocate;Alabama;anti-cancer research;Behavioral;Behavioral Research;Bioethical Issues;Bioethics;Bioethics Consultants;Biological Sciences;Biomedical Research;cancer clinical trial;cancer genomics;cancer health disparity;Clinical;Clinical Research;Clinical Trials;Collaborations;Communities;Community Health;Competence;Comprehensive Cancer Center;Consultations;design;Education;Education and Outreach;education research;Educational process of instructing;Endowment;Enrollment;Ensure;Ethical Issues;Ethics;ethnic minority;Evaluation;Faculty;Genomics;Good Clinical Practice;Guidelines;health disparity;Health Policy;Human Resources;Informed Consent;Institution;Laws;Logic;Malignant Neoplasms;medically underserved;Methods;minority communities;Modeling;Morehouse School of Medicine;new technology;online course;Outcome;outreach;Participant;patient navigator;Patients;Policies;Process;programs;racial minority;Recommendation;Research;Research Ethics;Research Personnel;Research Project Grants;Resource Sharing;rural area;social;Students;symposium;Thinking;tool;Training;Trust;undergraduate student;underserved community;underserved urban area;Universities

PROJECT_TITLE: Core 1: Bioethics Shared Resource


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Narrative: MIRA R35 GM122561 renewal Title: Dynamics and evolution of synthetic and natural gene regulatory networks Genes influence the behavior of cells, causing normal human tissues to become cancerous, or drug-sensitive microbial populations to become drug resistant. To cure diseases, we need to understand how genes control single cells and cell populations – but this is difficult because genes regulate each other, forming complex gene regulatory networks that function in a stochastic manner. We propose to study how natural gene networks function and evolve by developing computational models that mimic their behavior, and by perturbing them with human-designed synthetic gene circuits, hoping to understand gene network function from the consequent network changes combined with the observed behavior and adaptation of single cells and cell populations.

PI_NAMEs: BALAZSI, GABOR  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Behavior;behavior influence;Binding;Biological;cancer drug resistance;Cancerous;cell behavior;Cells;Code;Complex;Computer Models;design;Disease;Disparate;DNA;DNA Sequence;DNA Sequence Alteration;Drug resistance;drug-sensitive;Educational process of instructing;Environment;Evolution;gene network;gene product;gene regulatory network;Genes;genetic evolution;Human;human tissue;Individual;Mammalian Cell;microbial;Microbial Drug Resistance;Mutation;non-genetic;Nucleic Acid Regulatory Sequences;Pattern;Phenotype;Population;prevent;protein expression;Proteins;Research;single cell analysis;Synthetic Genes;Time;tumor progression;Untranslated RNA;Yeasts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Duchenne/ Becker Muscular Dystrophy;Heart Disease;Muscular Dystrophy;Pediatric;Rare Diseases

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it is focused on reducing the incidence and delaying the progression of dilated cardiomyopathy and heart failure in children with Duchenne and Becker Muscular Dystrophy (DMD and BMD). Demonstrating declines in peripheral vascular function, increased pulsatile load on the left ventricle, and determining their predictive capabilities of overall cardiac function will inform future interventional studies, including clinical trials that will alter the trajectory of care for these young patients struggling with DMD/BMD-related cardiomyopathy. Thus, the proposed research is relevant to the part of the NIH's mission that pertains to lengthening life and reducing illness and disability.

PI_NAMEs: WITMAN, MELISSA A.H. (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Animal Model;Animals;Aorta;arterial stiffness;Attenuated;attenuation;Becker Muscular Dystrophy;Biological Markers;Birth;Blood Vessels;Cardiac;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;Caring;Cause of Death;Cell Death;Characteristics;Child;clinical practice;Clinical Trials;cohort;Consensus;Cross-Sectional Studies;Data;density;design;Development;Diagnosis;Dilated Cardiomyopathy;disability;Disease Progression;Duchenne muscular dystrophy;Dystrophin;dystrophinopathy;Echocardiography;electric impedance;Endothelium;Exhibits;experience;Fibrosis;Functional disorder;Future;General Population;Genes;Goals;Health;Heart;Heart Diseases;Heart failure;heart function;Impairment;Incidence;innovation;Intervention Studies;Left ventricular structure;Leg;Life;longitudinal design;male;Measures;Methodology;Mission;Modeling;Morbidity - disease rate;mortality;Movement;Muscle;Muscular Dystrophies;Mutation;Myocardium;Neuromuscular Diseases;Nitric Oxide;Nitric Oxide Synthase Type I;NOS3 gene;novel;Outcome;Outcome Measure;Participant;Patients;Peripheral;Pharmaceutical Preparations;Physiologic pulse;pressure;Prognosis;Public Health;reactive hyperemia;Research;Respiratory Failure;Respiratory Muscles;Risk;Risk Factors;Skeletal Muscle;Testing;therapeutic target;Time;United States;United States National Institutes of Health;Vascular Diseases;Ventricular Remodeling

PROJECT_TITLE: Cardiovascular Consequences of Duchenne and Becker Muscular Dystrophinopathies

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome

PI_NAMEs: WU, FAN  (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Alabama;anti-cancer research;Applications Grants;Basic Science;Behavioral Sciences;Bioethics;Bioinformatics;bioinformatics resource;Bioinformatics Shared Resource;biomedical informatics;Biometry;cancer education;cancer health disparity;Cancer Research Project;career;career development;ChIP-seq;Clinical Research;Collaborations;Comprehensive Cancer Center;computer science;Consultations;Data;Data Analyses;data management;data mining;Data Science;Dedications;Development;DNA sequencing;Education;education research;Ensure;Epidemiology;Epigenetic Process;Evaluation;exome sequencing;Faculty;Funding;Grant;Incidence;Informatics;Institution;Manuscripts;Medical;Medicine;member;Mentorship;metabolomics;Methodology;Methods;Methylation;microbiome research;Minority-Serving Institution;miRNA expression profiling;Morehouse School of Medicine;mortality;multiple omics;next generation sequencing;outreach;Pathology;Pilot Projects;population based;Preparation;Productivity;professor;programs;racial disparity;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Risk;single cell analysis;single cell genomics;skills;sound;statistics;success;Technical Expertise;Training;transcriptome sequencing;Translational Research;Ubiquitination;Universities;Work

PROJECT_TITLE: Core 2: Biostatistics/Bioinformatics Shared Resource


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Building on a ~27-year effort in immunoregulation and ~10-year effort in cancer immunology, my goals in this application are to determine how regulatory T cells work and survive in the TME, and how this information might be leveraged to generate novel therapeutics for the treatment of cancer.

PI_NAMEs: VIGNALI, DARIO AA (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Ablation;anti-cancer research;Autoimmune;cancer clinical trial;cancer immunotherapy;Cancer Model;cancer therapy;Cell Physiology;cell type;Cells;Clinic;cytokine;Development;Disease;Dissection;Goals;Immune;Immunity;Immunology;immunoregulation;Immunotherapeutic agent;improved;inhibitor;Interleukins;Malignant Neoplasms;Modality;Nature;novel;novel strategies;novel therapeutics;NRP1 gene;Paper;Patients;Phase;programs;receptor;Regulatory T-Lymphocyte;Reporting;Research;Science;Seminal;Therapeutic;Therapeutic Intervention;therapy outcome;Translations;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;Work

PROJECT_TITLE: Regulatory T cells and the tumor microenvironment