FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative  This project aims to develop a rapid and robust quantitative magnetization transfer imaging method sensitive to early in vivo amyloid beta pathology in cognitively normal individuals. This innovation is enabled by the use of two key technologies: the hybrid spin-ensemble state and unrolled neural networks. Successful completion of this project will establish quantitative magnetization transfer as a viable technique for tracking Alzheimer's disease progression and monitor patient's responses to novel drug therapies.

PI_NAMEs: MAO, ANDREW  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: abeta accumulation;Address;aging population;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease therapeutic;American;Amyloid;Amyloid beta-Protein;amyloid pathology;beta amyloid pathology;Binding;Biological Markers;biophysical properties;Biophysics;Brain;burden of illness;career;cerebral atrophy;Cessation of life;Clinical;clinical development;Clinical Management;clinical practice;Clinical Research;Cognitive;Data;data space;deep learning;Dementia;Demyelinations;detection method;Diagnostic;Disease;Disease Progression;Early Diagnosis;Fellowship;Health Care Costs;Heart Diseases;high resolution imaging;HIV;Hybrids;Image;image reconstruction;image translation;imaging modality;Imaging Techniques;Impaired cognition;improved;in silico;in vivo;Individual;innovation;interest;interstitial;Lipids;Literature;macromolecule;magnetic field;Magnetic Resonance Imaging;Maps;Measures;Methods;mild cognitive impairment;Modeling;Monitor;mouse model;Myelin;Nerve Degeneration;Network-based;neural network;Neurobehavioral Manifestations;Neurodegenerative Disorders;Noise;novel therapeutics;Outcome;Pathology;Patient Monitoring;patient population;patient response;Patients;Pharmacotherapy;Physiologic pulse;Pilot Projects;Population;Positron-Emission Tomography;pre-clinical;prisma;Process;Proteins;Protons;reconstruction;Relaxation;Reporting;Reproducibility;Research;Resolution;Scanning;Signal Transduction;Stroke;Structure;Surrogate Markers;tau Proteins;Technical Expertise;Techniques;Technology;Testing;theories;Time;Tissues;tool;Training;treatment response;United States;Water;Work

PROJECT_TITLE: Quantitative Magnetization Transfer Imaging for Early Detection of Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-Y(20)L]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Foodborne Illness

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The Research Experience Training Coordination Core will expand the population of professionals able to conduct and interpret research relating to human exposure to and health effects of emerging drinking water contaminants and produce cross-trained scientists, engineers, and biomedical researchers with the broad communication skills required to effectively address emerging environmental research and health questions.

PI_NAMEs: CHEN, YING  (contact)

PROJECT_TERMS: academic preparation;Address;Area;base;Biological;Biological Markers;Biomedical Research;Biosensor;Chemicals;Chemistry;Communication;Communities;community engagement;Community Outreach;community partners;Competence;Connecticut;Data Analyses;Data Analytics;data management;design;Development;Dioxanes;Discipline;doctoral student;drinking water;Early identification;Education;Educational process of instructing;Educational workshop;Engineering;Ensure;environmental chemical;environmental chemistry;Environmental Engineering technology;Environmental Health;Environmental Protection;Evaluation;experience;exposed human population;Exposure to;Faculty;Fostering;Genetic;Goals;Government Agencies;Health;Hepatocarcinogenesis;improved;Industry;Information Dissemination;Infrastructure;Interdisciplinary Study;Joints;Knowledge;liver injury;Malignant neoplasm of liver;medical schools;Medicine;Mentors;Mentorship;metabolomics;Monitor;next generation;novel;oxidation;Play;Population;Postdoctoral Fellow;potential biomarker;pre-doctoral;Privatization;Process;Program Research Project Grants;programs;Public Health;Public Health Schools;recruit;remediation;reproductive;Research;Research Activity;Research Personnel;Risk;Role;Scientist;sensor;skills;Students;Superfund;symposium;synergism;Technology;Toxicology;Training;Training Programs;Translational Research;Universities;University resources;Update;Water Pollutants;Water Supply

PROJECT_TITLE: Research Experience & Training Core


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: PORTLAND

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE Identifying solutions for the treatment of microbial infections, aberrant immunological diseases, and other emerging global health problems requires combined expertise and collaboration among scientists. A better understanding of the mechanisms by which pathogens infect multicellular eukaryotic hosts and how hosts, in turn, defend themselves against pathogens is critical for developing new alternative strategies to manage microbial infections and better understand the function of the immune system. Real world solutions are possible by investing in the training of new investigators to become facile in thinking and working across multiple disciplines to solve complex problems related to microbial pathogenesis, immunity, and host defense.

PI_NAMEs: CAPOSIO, PATRIZIA ;LANDFEAR, SCOTT M (contact);PRUNEDA, JONATHAN N

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TITLE: Interdisciplinary Training in Microbial Pathogenesis and Immunology

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: NS

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Complementary and Integrative Health;Depression;Genetics;Human Genome;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pain Research

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: This proposal utilizes both human postmortem brain tissues and a preclinical model of rodent stress to study astrocyte plasticity and how it contributes to the pathophysiology of inflammation-related psychiatric disease, such as MDD, which is a high priority public health interest. The project aims to use single-nuclei resolution RNA- seq to characterize the functional changes in cellular maps and transcriptomes resulting from astrocyte-specific inflammation in the rodent orbitofrontal cortex, a brain structure critically involved in reward processing, motivation, and anhedonia. Examining the regulatory drivers of gene expression changes during astrocyte inflammation will help identify novel pharmacotherapeutic targets aimed at normalizing or reversing inflammation-induced neuroadaptations that underlie the pathophysiology of stress-related disorders, including MDD.

PI_NAMEs: FULTON, SASHA  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Anhedonia;Animals;Area;Astrocytes;ATAC-seq;Autopsy;Behavioral;Binding;biological adaptation to stress;Brain;Brain region;brain tissue;Cell Nucleus;Cell Physiology;cell type;Cells;Chromatin;chromatin remodeling;Chromatin Structure;Chronic inflammatory pain;Chronic stress;cohort;Communication;Complex;Coupled;Decision Making;disease model;Electrophysiology (science);Environment;Exhibits;experimental study;Expression Profiling;Faculty;frontal lobe;Functional disorder;Future;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Grant;Human;Hyperactivity;Impairment;Inflammation;Inflammatory;Inflammatory Response;interest;Laboratories;Major Depressive Disorder;Maps;Mediating;member;Mental Depression;Mental disorders;Mentors;Molecular;Molecular Genetics;Motivation;Mus;neural;neuroadaptation;Neuroglia;Neurons;Neurosciences Research;neurotoxic;neurotransmission;NF-kappa B;novel therapeutics;overexpression;Pain;Pathway interactions;Phenotype;Population;Postdoctoral Fellow;Pre-Clinical Model;Process;Proteins;public health priorities;Regulation;Research;resilient behavior;Resolution;response;reward processing;Rewards;Rodent;Rodent Model;Role;Series;Signal Transduction;single nucleus RNA-sequencing;skill acquisition;social;somatosensory;Sorting;Stress;stress related disorder;stressor;Structure;Symptoms;Synapses;Synaptic Transmission;Techniques;Therapeutic;Tissues;Touch sensation;Training;transcriptome;transcriptome sequencing;transcriptomics;Up-Regulation;vector;Viral;Work

PROJECT_TITLE: Defining the Differential Role of Mrgprb4+ Social Touch Somatosensory Neurons in Pain Modulation and Frontolimbic Dysregulation During Chronic Inflammatory Pain


ADMINISTERING_IC: OD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Human Genome;Rural Health

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative The use of genetically engineered (GE) pigs is critical for advancing both biomedical and agricultural applications but are underutilized, in part, due to the safety and efficacy of the technology, as well as, the time required to establish and propagate these models. Developing strategies that assist in preserving genome integrity and for rapid identification of phenotypes will allow for the rapid expansion of GE pig models. Increasing the availability of GE pig models will have clear impacts on preclinical models for gene therapy and quickly identifying pigs with improved agricultural traits.

PI_NAMEs: LEE, KIHO  (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Agriculture;Alleles;Anatomy;Animal Model;Animals;Area;Biochemical;Biological;Biological Assay;Biology;Breeding;Clinic;Clinical;clinical effect;clinical outcome assessment;clinical phenotype;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Cystic Fibrosis;Data;design;Detection;detection platform;Disease;disease phenotype;Early Diagnosis;efficacy evaluation;Embryo Cloning;Event;Exclusion;Family suidae;fetal;Fetus;Food production;gene function;gene therapy;Genes;Genetic;Genetic Diseases;genetic element;Genetic Engineering;Genome;genome editing;genome integrity;genome sequencing;Genomics;Goals;Heritability;Human;human disease;Immune;Immune response;immunodeficiency;improved;in vivo;inhibitor;Investments;Knowledge;Length;Life Cycle Stages;Link;Livestock;Methods;Modeling;Modification;Molecular;Monitor;novel;novel strategies;Outcome;Patients;Phenotype;Physiology;pig genome;porcine model;Porcine respiratory and reproductive syndrome virus;postnatal;Pre-Clinical Model;predictive tools;Pregnancy;preservation;Procedures;Process;Production;Puberty;Research;Research Activity;Resistance;Resources;response;Safety;Secure;side effect;single-cell RNA sequencing;Site-Directed Mutagenesis;small molecule;Somatic Cell;Symptoms;System;Technology;Testing;therapy outcome;Time;tool;trait;United States Department of Agriculture;United States National Institutes of Health;Variant;whole genome

PROJECT_TITLE: Enhancing The Value of Pigs for Agriculture and Biomedical Applications By Using Novel Genome Editing Strategies


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The goal of the Integrated Program in Cellular, Molecular and Biomedical Studies is to provide students with a unique opportunity to obtain individualized training in basic cell and molecular biology, microbiology, structural biology, biophysics, genetics, immunology, neurobiology, systems and computational biology, as well as translational biomedical disease-related research. They will receive training in responsible conduct of research and learn how to do rigorous and reproducible research.

PI_NAMEs: HAEUSLER, REBECCA ANNE;LIEM, RONALD K. (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Molecular;Training

PROJECT_TITLE: Training in Cellular, Molecular and Biomedical Studies (CMBS)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: ALBUQUERQUE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE Hantavirus disease is a form of zoonotic viral hemorrhagic fever (VHF) that results when humans inhale excreta from hantavirus-infected rodents, with case-fatality rates exceeding 40% for some hantaviruses. In its natural reservoir host, the brown rat, Seoul virus causes asymptomatic, lifelong infection, posing a persistent threat to humans worldwide due to the global rat distribution. The work proposed here leverages the genetic, immunological, and commercially available tools of the laboratory rat reservoir model to investigate the innate immune mechanisms driving differential disease outcomes in reservoir and non-reservoir hosts for hantavirus.

PI_NAMEs: KELL, ALISON  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Adherens Junction;antagonist;Anti-viral Response;Asia;Automobile Driving;Binding;Biomedical Research;Blood;Blood Vessels;Cardiopulmonary;Case Fatality Rates;cell motility;Cell Physiology;Cells;chemokine;chronic infection;Coagulation Process;comparative;Connexins;cytokine;Cytoplasm;Data;Disease;Disease Outcome;Endothelial Cells;Endothelial Growth Factors Receptor;Endothelium;Etiology;Extravasation;Family;Gene Expression;Genetic;Genomics;Hantaan virus;Hantavirus;Hantavirus Infections;Hemorrhagic Fever with Renal Syndrome;Human;human disease;Immune;immune activation;Immune signaling;Immunologics;Immunology;In Vitro;in vivo;infected vector rodent;Infection;Inflammation;Inflammatory;Inhalation;innate immune mechanisms;Interferon Activation;Interferon Type I;Interferons;Investigation;Kidney;Laboratory Rat;Leukocytes;Literature;Location;Lung;Mediating;migration;Modeling;Molecular;Natural Immunity;neutrophil;Neutrophil Activation;Neutrophil Infiltration;novel;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathway Analysis;Pathway interactions;Pattern;Permeability;Platelet Activation;preservation;Publishing;Rattus;Rattus norvegicus;receptor;recruit;Regulation;Regulatory T-Lymphocyte;Resources;response;RNA;RNA Viruses;Rodent;Role;Seoul virus;Signal Induction;Signal Pathway;Signal Transduction;Site;Source;Stimulus;Syndrome;Testing;Therapeutic;Tissue-Specific Gene Expression;Tissues;tool;Transcriptional Activation;transcriptomics;Vascular Diseases;Vascular Endothelial Growth Factors;vascular inflammation;Viral;viral detection;Viral Hemorrhagic Fevers;Virus Diseases;virus host interaction;Virus Replication;Work;wound healing;Zoonoses

PROJECT_TITLE: Role of Type I IFN Signaling in Seoul Orthohantavirus Pathogenesis


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: SYRACUSE

ORG_DEPT: CHEMISTRY

ORG_NAME: SYRACUSE UNIVERSITY

PHR: Despite broad interest in understanding the biological implications of protein lipidation, how the structure of appended lipids regulates the conformation and function of disease-related lipidated proteins remains unclear. To close this gap, this MIRA program will elucidate the biophysical rules governing assembly, aggregation, and function of physicochemically diverse libraries of lipidated proteins, prepared from operationally simple, high- yield biosynthetic routes. These biophysical insights will contribute to a mechanistic understanding of the role of lipidated proteins in health and disease and facilitate the application of lipid-modification in the development of next-generation drug carriers, biomaterials, and therapeutics.

PI_NAMEs: MOZHDEHI , DAVOUD   (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Amino Acids;aqueous;Behavior;Biocompatible Materials;Biological;Biophysics;Biotechnology;Cellular biology;Complex;design;Development;Disease;Drug Carriers;Engineering;Generations;Genetic Engineering;Health;Human;human disease;insight;interest;Libraries;Lipids;Liquid substance;Mechanics;Membrane;Methods;Modeling;Modification;Molecular;Molecular Conformation;nanomedicine;next generation;Organizational Models;Phase;Physical condensation;Post-Translational Protein Processing;programs;Prokaryotic Cells;Property;Protein Conformation;protein structure;Proteins;Research;Role;Route;Signal Transduction;Site;Structure;syntax;Techniques;Testing;Therapeutic;viscoelasticity

PROJECT_TITLE: Genetically Encoded Lipidation to Manipulate Structure, Assembly, and Phase Behavior of Proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Microbiome;Nutrition;Precision Medicine;Prevention

ORG_CITY: BOSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE Given the increasing burden of obesity, diabetes, and heart disease in the community, new methods are necessary to identify individuals who are at greatest risk of developing these conditions. For this purpose, we propose to measure small molecules in the blood (that reflect body metabolism) before and after a standardized meal challenge in a large community-based sample. Our results will clarify how intake of meals results in dissimilar patterns of small molecules in blood in different people and how these distinctive patterns may identify novel markers of heart disease and diabetes risk that may not be apparent with blood measures obtained in a fasting state.

PI_NAMEs: NAYOR, MATTHEW G. (contact)

PROGRAM_OFFICER_NAME: POOL, LINDSAY REGINA

PROJECT_TERMS: Address;Adipose tissue;Age;Bioinformatics;Biological;Biological Assay;Biometry;Blood;Blood specimen;Body mass index;Body System;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular risk factor;Cardiovascular system;Categories;Cessation of life;clinical risk;cohort;Communities;Consumption;Coronary Artery Risk Development in Young Adults Study;Coronary heart disease;Data Analyses;Development;Diabetes Mellitus;diabetes risk;Disease Outcome;disorder risk;Drug Modulation;endophenotype;energy balance;energy efficiency;Epidemiology;Event;experience;Fasting;Fatty acid glycerol esters;flexibility;Framingham Heart Study;Functional disorder;Funding;Future;Generations;genetic epidemiology;genetic variant;Genetic Variation;Glucose;Goals;gut microbiome;Health;health definition;heart disease risk;Heart Diseases;Heterogeneity;high dimensionality;Hour;Human;Human Biology;Impairment;improved;Individual;innovation;insight;Insulin Resistance;Intake;Kidney;Link;Liver;Measures;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;Methods;microbiome composition;Molecular;molecular marker;multi-racial;Neurologic;novel;novel marker;Obesity;Oral;Organ;Outcome;Pancreas;Participant;Pathway interactions;patient oriented research;Pattern;Persons;Phenotype;Physiological;Populations at Risk;Positioning Attribute;preservation;Process;prognostic significance;Proteins;Public Health;Reproducibility;Research;Research Personnel;Resources;response;Rest;Risk;Risk Factors;risk prediction;Sampling;sex;Skeletal Muscle;small molecule;Standardization;Stress;stressor;System;Testing;trait;translational study;young adult

PROJECT_TITLE: Metabolic Responses to an Oral Mixed Meal Tolerance Test: Intra-individual changes, correlates, and prognostic significance

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Genetics;Mental Health;Mental Illness;Patient Safety;Pediatric;Precision Medicine;Serious Mental Illness;Suicide

ORG_CITY: CINCINNATI

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE Anxiety disorders are common in children and adolescents; however, up to 40% of pediatric patients fail to respond to the first-line antidepressant treatment. We hypothesize that pharmacogenetically-guided dosing of the antidepressant escitalopram will increase treatment response while decreasing medication side effects in adolescents with anxiety disorders. We believe that this study will inform clinicians, patients, parents, and payers whether pharmacogenetically-guided escitalopram dosing in pediatric anxiety disorders improves outcomes for anxious adolescents who need antidepressant medications.

PI_NAMEs: RAMSEY, LAURA B;STRAWN, JEFFREY ROBERT (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Age;aged;Agitation;anti-depressive agents;Anxiety;Anxiety Disorders;anxiety symptoms;anxious;Blinded;Body mass index;Child;Childhood;childhood anxiety;Chronic disability;Clinical;CYP2C19 gene;CYP2D6 gene;Data;Development;Disease;Distress;Dose;Drug Kinetics;Effectiveness;Escitalopram;experience;Family Relationship;FDA approved;Functional impairment;Genes;Genotype;Guidelines;Health Care Costs;high risk;HTR2A gene;Impairment;improved;improved outcome;inpatient psychiatric treatment;Major Depressive Disorder;Measures;Medical center;Morbidity - disease rate;neuropsychiatry;Outpatients;Parents;Patients;Pediatric Hospitals;pediatric patients;Performance;Pharmaceutical Preparations;Pharmacodynamics;Pharmacogenetics;Pharmacogenomics;Plasma;Poly(ADP-ribose) Polymerases;Population;Prediction of Response to Therapy;prospective;Prospective Studies;Psychopathology;psychopharmacologic;psychosocial;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;receptor;Recommendation;response;Retrospective Studies;Risk;Safety;Schools;Selective Serotonin Reuptake Inhibitor;serotonin transporter;Severities;side effect;Sleeplessness;social relationships;Substance Use Disorder;success;suicidal;suicidal risk;Suicide attempt;Testing;Time;Treatment Cost;treatment optimization;treatment response;Variant;week trial;Weight Gain;Youth

PROJECT_TITLE: Improving the Effectiveness and Safety of Escitalopram in Pediatric Anxiety


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The University of Chicago (UChicago) Medical Scientist Training Program (MSTP) is designed for trainees pursuing broad careers in research relevant to human health and disease. We seek to fulfill a national need for individuals who will apply clinical and research experience to biomedical investigation by providing trainees with access to the very best resources of the University, and by catalyzing the application of multidisciplinary approaches to solve the most pressing problems in medical science. The UChicago MSTPs’ distinctive interdisciplinary approach encourages trainees to explore their medical and research interests in the broadest possible terms in medicine, biology, and the physical sciences.

PI_NAMEs: CLARK, MARCUS RAMSAY (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Medical;National Research Service Awards;Scientist

PROJECT_TITLE: Medical Scientist National Research Service Award

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Using two different modalities capable of imaging intact tissue, we will identify spatial changes in metabolites and proteins during the progression of Alzheimer's disease. By comparing these changes in a vulnerable brain region with a resilient brain region and integrating data on location and morphology of various cell types in these brain regions, we aim to determine metabolic and protein signaling pathways contributing to cellular vulnerability in Alzheimer's disease. Outcomes from this study will provide insights into the mechanisms leading to neurodegeneration and reveal targets within pathways that could be protective in Alzheimer's disease.

PI_NAMEs: MALLICK, PARAG KUMAR;SCHIAVINATO EBERLIN, LIVIA ;VARGHESE, MERINA THEKENANGARPADIYIL (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Alzheimer's disease pathology;Architecture;Area;area striata;Autopsy;biomarker identification;Blood Vessels;Brain;Brain region;cell type;Cells;Chimera organism;Classification;Clinical;comparative;comparison control;Computer Vision Systems;Data;data integration;Data Set;density;Detection;Development;differential expression;Disease;Disease Progression;Disease susceptibility;Energy Metabolism;Environment;Exhibits;Experimental Models;Feasibility Studies;Future;Genetic;Goals;gray matter;hippocampal pyramidal neuron;Human;humanized mouse;Image;imaging capabilities;imaging detection;Imaging Device;imaging modality;imaging study;Imaging Techniques;Immunofluorescence Immunologic;In Situ;Individual;Inflammation;insight;Intervention;Knowledge;Laboratories;large datasets;Location;Machine Learning;mass spectrometric imaging;Mass Spectrum Analysis;Measures;Metabolic;metabolic imaging;Metabolic Pathway;metabolic profile;Modality;Modeling;Molecular;molecular imaging;molecular phenotype;Molecular Profiling;Morphology;Mus;Myelin;Neighborhoods;Neocortex;neocortical;Nerve Degeneration;Neuroglia;neuroinflammation;Neurons;neuropathology;novel;Organoids;Outcome Study;Oxidative Stress;Pathologic;Pathway interactions;Pattern;Phase;Phenotype;Pilot Projects;Population;Predisposition;Prefrontal Cortex;protein aggregation;Proteins;Proteomics;Pyramidal Cells;regional difference;resilience;Resistance;Resolution;risk variant;segregation;Senile Plaques;Severities;Signal Pathway;Signal Transduction;Signaling Protein;Slide;small molecule;Spatial Distribution;spatial relationship;Specimen;tau aggregation;Testing;Tissue Microarray;Tissue Stains;Tissues;tool;transcriptomics;Validation;Visual;white matter

PROJECT_TITLE: Mass spectrometry and multiplexed immunofluorescence imaging of metabolic and proteomic contributors to selective neuronal vulnerability in Alzheimer's disease


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE The United States Department of Agriculture has sponsored the Summer Food Service Program since 1975 to address the summertime nutritional gap experienced by children from low-income families. It provides meals to children, however, characteristics of the program providers and participants as well as the program’s impact on child health outcomes are not well-documented. The proposed project aims to address the research gap by identifying details about the program providers and users and assessing changes of children’s food insecurity, diet quality and weight gain accounting for the program usage, which will guide further program improvements and provide a venue for an innovative summer childhood obesity prevention program.

PI_NAMEs: LEE, JIWOO  (contact)

PROGRAM_OFFICER_NAME: CLARK, DAVID

PROJECT_TERMS: Accounting;Address;Affect;Area;Behavior;Behavioral;Body fat;Body mass index;Body Weight Changes;Body Weight decreased;career;career development;Career Mobility;Characteristics;Child;Child Health;Child Nutrition;cohort;Communities;community collaboration;community partners;cost effective;Data Collection;demographics;Development;Diet;dietary;Disparity;Doctor of Philosophy;Educational Activities;elementary school;Eligibility Determination;Equation;Equity;Evaluation;experience;Family Sizes;family structure;Food;food insecurity;Food Services;Funding;Future;Goals;Health;health disparity;health equity;Health Status;Healthy Eating;Height;Heterogeneity;Hour;Household;implementation intervention;implementation science;improved;indexing;innovation;interest;Intervention;Knowledge;Length;Low income;lower income families;Measurement;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;metropolitan;Minnesota;Mission;Modeling;multidisciplinary;Nonprofit Organizations;nutrition;Nutritional;nutritional guideline;Obesity;obesity in children;obesity prevention;Observational Study;operation;Outcome;Overweight;Parents;Participant;Physical activity;portability;Positioning Attribute;Preparation;Prevention program;preventive intervention;Price;Program Description;programs;prospective;Provider;psychosocial;Public Health;Random Allocation;recruit;Reporting;Research;Research Personnel;Research Project Grants;Role;Sampling;school district;School-Age Population;Schools;Scientist;service programs;Services;Site;skills;Social Environment;Sports;Surveys;therapy design;therapy development;Training;Twin Cities;United States Department of Agriculture;United States National Institutes of Health;Universities;Weight;Weight Gain;Work

PROJECT_TITLE: Reducing the summer health gap: Evaluation of a community-based child nutrition assistance program


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Comparative Effectiveness Research;Genetic Testing;Genetics;Human Genome;Precision Medicine;Prevention;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: High risk prostate cancer (PCa) accounts for the vast majority of deaths from localized PCa, a very common disease, and is often treated with a “one-size-fits-all” strategy of radiation therapy (RT) and long-term androgen deprivation therapy (ADT). While this strategy optimally treats the 20% of patients who need long-term ADT for cure, it undertreats the 50% of men whose cancer will recur despite this therapy and needed treatment intensification, and overtreats the 30% of men who could have been cured by only very short-term ADT and could have avoided prolonged ADT side effects. There are no clinical-grade biomarkers that can differentiate these three groups prior to treatment, so we will develop and validate cost-effective biomarkers, for patients with high-risk PCa treated with RT, that can differentiate these groups and allow personalization of their systemic therapy to maximize their treatment response and minimize unnecessary toxicities.

PI_NAMEs: FENG, FELIX YI-CHUNG (contact);NGUYEN, PAUL L

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Acute;Address;androgen deprivation therapy;arm;Bioinformatics;Biological Markers;biomarker panel;biomarker signature;Cancer Patient;Cardiovascular system;Cessation of life;chemotherapy;CLIA certified;Clinical;Clinical Management;clinical predictors;clinical translation;cost;cost effective;cost effectiveness;Data;Decision Analysis;Decision Making;density;Diagnosis;Disease;Event;Exposure to;Fracture;Future;Gene Expression Profile;genetic signature;genomic signature;Genomics;Goals;Guidelines;Health Benefit;Health Care Costs;high risk;Impaired cognition;improved;Malignant neoplasm of prostate;Malignant Neoplasms;markov model;men;Mental Depression;molecular marker;National Comprehensive Cancer Network;new therapeutic target;novel;Oligonucleotide Microarrays;Operative Surgical Procedures;overtreatment;Pathologic;patient population;patient subsets;Patients;personalized medicine;Phase;phase III trial;predicting response;predictive marker;predictive modeling;predictive signature;prognostic;Prognostic Marker;prognostic signature;prognostic tool;prognostic value;Prostate;prostate cancer risk;Publishing;Radiation therapy;Radiation Therapy Oncology Group;randomized trial;Recurrence;Recurrent disease;Research;response;Sampling;Sexual Dysfunction;side effect;specific biomarkers;standard of care;Systemic Therapy;targeted agent;Therapeutic;therapy duration;Tissues;Toxic effect;treatment response;treatment strategy;tumor;Use Effectiveness;Validation

PROJECT_TITLE: Biomarker Approaches to Individualizing Systemic Therapy for High Risk Prostate Cancer

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative: The goal of my research program is to investigate mechanisms by which Gram-positive bacteria maintain translation fidelity and efficiency. We will determine how ribosome stalling impacts cellular physiology and proteome integrity, and how protein synthesis can be regulated by atypical translation events such as frameshifting and stop codon read-through. Knowledge gained from these studies will increase our understanding of essential ribosome rescue pathways and uncover new antibiotic targets.

PI_NAMEs: FEAGA, HEATHER  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Antibiotic Resistance;Antibiotics;Area;Bacillus anthracis;Bacillus subtilis;Biochemical;biological adaptation to stress;Cell Physiology;Cells;Code;Data;Event;flexibility;Gene Expression;Genetic;Goals;Gram-Negative Bacteria;Gram-Positive Bacteria;Infection;interest;Knowledge;Laboratories;Modeling;Pathway interactions;Physiological;premature;prevent;Process;programs;Protein Biosynthesis;Protein Truncation;Proteome;Quality Control;Regulation;Research;Ribosomes;Terminator Codon;Translational Regulation;Translations;United States

PROJECT_TITLE: Ribosome Quality Control Mechanisms in Gram-positive Bacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Aging;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Transplantation

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative  Our goal with this work is to identify the basis for the progressive white matter loss that characterizes aging, with a focus on the failure of remyelination by glial progenitor cells (hGPCs) that attends both aging and age-associated neurodegenerative disorders. We will do so by establishing human glial chimeric mice with embryonic stem cell-derived hGPCs that have been subjected to serial mitotic expansion in vitro before transplant, comparing the in vivo colonization and myelination competence of hGPCs of different ages, and as a function of time after neonatal engraftment; conversely, we will transplant young hESC GPCs into older adult brains, and compare their expansion and differentiation competence to that of aged hGPCs in the same grafts. We will then use RNA sequence analysis – both bulk and single cell - together with both ATAC-Seq determination of chromatin occupancy, and measures of DNA methylation state and telomeric length, to define the effect of aging on the transcription and epigenetic state of hGPCs in vivo, our goal being to define and target those age- associated repressors that may delimit hGPC competence, and by suppressing their expression, to restore the expansion and fate competence of aged human glial progenitor cells.

PI_NAMEs: GOLDMAN, STEVEN ALAN (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Adult;Affect;Age;age effect;age related;age related neurodegeneration;aged;Aging;aging brain;aging process;aging related;aging related disease;Astrocytes;ATAC-seq;Back;Biology;Brain;cell age;Cell Aging;Cell Communication;Cell division;Cells;Characteristics;Chromatin;Chronic;Competence;Data;Demyelinations;design;Disadvantaged;Disease;DNA Methylation;embryonic stem cell;Engraftment;Environment;Epigenetic Process;experimental study;Failure;fetal;functional restoration;Gene Expression Profile;Genes;Genetic;Genetic Suppression;Genetic Transcription;Goals;host colonization;Human;human embryonic stem cell;In Vitro;in vivo;Inflammatory;interest;knock-down;Length;lentivirally transduced;life span;Link;Maintenance;Measures;Methylation;methylation pattern;migration;Mitotic;Molecular;Multiple Sclerosis;Mus;Myelin;myelination;Neonatal;neonate;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuroinflammation;NFIB gene;older adult;Oligodendroglia;overexpression;Pattern;Phenotype;Population;preservation;prevent;progenitor;Proliferating;Recurrence;remyelination;resilience;response;RNA analysis;RNA Sequence Analysis;Role;self-renewal;senescence;stem cell aging;stem cell expansion;stem cell fate;stem cells;telomere;Therapeutic;Time;Tissues;transcription factor;Transplantation;Transplantation Chimera;white matter;White Matter Disease;Work

PROJECT_TITLE: Cell-intrinsic and contextual determinants of aging by human glial progenitor cells


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: 8. Project Narrative Adolescence is an “age of risk” for the emergence of bipolar spectrum disorders (BSDs), a major public health problem. Using an innovative biobehavioral high-risk approach with a prospective, longitudinal design, this application will examine bidirectional relationships between circadian and reward function at multiple levels of analysis and their joint prediction of first onset of BSD and increases in hypomanic/manic and depressive symptoms. It will provide critical tools for identifying vulnerabilities for first onset of BSD, integrate two separate research traditions to increase our understanding of specific etiological pathways to BSD, and facilitate development of behavioral and biological interventions for ameliorating reward processing and circadian rhythm abnormalities that contribute to BSDs, and their lifelong negative consequences.

PI_NAMEs: ALLOY, LAUREN BERSH (contact);NUSSLOCK, ROBIN

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: 16 year old;actigraphy;Adolescence;Adolescent;Affect;Age;Behavioral;biobehavior;Biological;bipolar spectrum;Brain;Chronic;circadian;Circadian Dysregulation;Circadian Rhythms;Code;depressive symptoms;design;Development;Diagnostic;Dimensions;Disease;Ecological momentary assessment;Etiology;Event;Exclusion;Feedback;functional MRI scan;Goals;high reward;high risk;Hypersensitivity;hypomania;indexing;innovation;Intervention;Joints;Life;Light;Literature;longitudinal design;Longitudinal Studies;Manic;Measures;Mediating;Mediator;Melatonin;Modeling;mood symptom;Moods;negative affect;neural;neuroimaging;novel;Onset of illness;Participant;Pathway interactions;Patient Self-Report;Phase;Physiological;Prevalence;prevent;Procedures;prospective;Public Health;Recording of previous events;Recurrence;Research;reward processing;Rewards;Risk;Risk Marker;Salivary;Sampling;Signal Transduction;Sleep;social;social engagement;Stimulus;Symptoms;synergism;System;Tail;Testing;Time;tool;trait;Work

PROJECT_TITLE: Integrated Reward-Circadian Rhythm Model of First Onset of Bipolar Spectrum Disorders in Adolescence

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative The UVA Pharmacological Sciences Training Program (PSTP) teaches talented scientists to apply innovative approaches to pressing biomedical problems using Pharmacologic methods. Our diverse graduates are poised to become the next generation of leaders in academia, government and the pharmaceutical industry.

PI_NAMEs: BLAND, MICHELLE L;HARRIS, THURL E.;LYNCH, KEVIN R. (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: pharmacologic;Science;Training

PROJECT_TITLE: Training in the Pharmacological Sciences


NIH_SPENDING_CATS: Genetics

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE The microenvironment shapes cellular function and this process involves transmitting signals from extracellular cues to a specific set of response genes. Our goal is to understand how the factors that transmit signals and direct gene expression can initiate diverse, yet context-specific gene programs, thus yielding insights into dysregulated gene expression and disease susceptibility. This work is highly relevant to NIGMS’s mission of seeking fundamental understanding of biological processes to lay foundations for novel therapeutic strategies.

PI_NAMEs: GOTTSCHALK, RACHEL A (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Anti-Inflammatory Agents;Biochemical;Biological Process;Biology;Cell Physiology;Cells;Complex;Cues;cytokine;Data;Disease susceptibility;Event;Excision;extracellular;Family;Foundations;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Genomics;Goals;Immune;insight;Laboratories;Link;Mission;Modeling;National Institute of General Medical Sciences;novel therapeutic intervention;Pathology;Phosphorylation;Post-Translational Protein Processing;Predictive Factor;Process;programs;response;Shapes;Signal Pathway;Signal Transduction;Specificity;STAT protein;Stimulus;transcription factor;transcriptomics;transmission process;Work

PROJECT_TITLE: Quantitative control of phosphorylation and mechanistic links to immune cell decisions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cystic Fibrosis;Gene Therapy;Genetics;Lung;Nanotechnology;Orphan Drug;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative  The proposed research is directly relevant to public health in that it is aimed at developing a cure for cystic fibrosis and incorporates key steps towards the clinical translation of a therapeutic. Further, the research will develop tools for therapeutic screening and enhancing fundamental knowledge of drug delivery mechanisms. Overall, this work has the potential to contribute to the treatment of devastating genetic diseases, significantly improving the health of patients and reducing the burden of illness.

PI_NAMEs: PIOTROWSKI-DASPIT, ALEXANDRA SARAH ANNUKKA (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: 3-Dimensional;Amines;base editing;Base Pairing;Binding;Biocompatible Materials;biodegradable polymer;Biodistribution;Biology;Biomedical Engineering;burden of illness;career;career development;Cell Line;cell type;Cells;Chemical Engineering;Chlorides;Circulation;clinical translation;Clinical Trials;clinically relevant;Communities;CRISPR/Cas technology;curative treatments;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;delivery vehicle;design;design and construction;Development;Development Plans;Diagnosis;Disease;disease model;disease-causing mutation;DNA;DNA Repair;Doctor of Philosophy;Drug Delivery Systems;Encapsulated;endonuclease;engineered nucleases;Engineering;Esters;experience;experimental study;Family;gene editing technology;Genes;Genetic;Genetic Diseases;genome editing;Goals;Guide RNA;Half-Life;Health;Hereditary Disease;high throughput screening;high throughput technology;Impairment;improved;In Vitro;in vitro Model;in vitro testing;in vivo;innovation;Interdisciplinary Study;Knowledge;Libraries;Lung;Lung Diseases;Lung infections;Mentors;Methods;Modeling;Mutation;nanomedicine;nanoparticle;nanopolymer;Nanotechnology;Nonsense Codon;novel;nuclease;nucleic acid delivery;nucleic acid-based therapeutics;Oligonucleotides;Organoids;Other Genetics;Patients;Peptide Nucleic Acids;Physiological;Physiology;Polymer Chemistry;Polymers;Postdoctoral Fellow;prime editing;Proteins;Public Health;rational design;Reagent;Regulator Genes;Reporter;Research;Research Personnel;response;Reverse engineering;RNA-Directed DNA Polymerase;safety assessment;Scientist;screening;Screening procedure;Site;skills;Structure-Activity Relationship;System;Technology;Testing;Therapeutic;Therapeutic Agents;therapeutic development;therapeutic genome editing;three dimensional cell culture;three-dimensional modeling;Tissue Engineering;Tissues;tool;Training;Translations;Treatment Efficacy;United States;Universities;uptake;Work

PROJECT_TITLE: Developing Gene Editing Therapeutics, Biodegradable Polymeric Delivery Vehicles, and High-throughput Platforms for the Treatment of Cystic Fibrosis

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Nutrition;Obesity;Substance Misuse

PHR: PROJECT NARRATIVE Excess consumption of ultra-processed (UP) foods (i.e., foods that are composed of mostly cheap industrial sources of dietary energy and nutrients plus additives) has strong biopsychobehavioral parallels with substance use disorders (SUD). Withdrawal is a core element of SUD and emerging evidence suggests that reducing UP food intake may result in symptoms of withdrawal for at-risk individuals, although this research is limited by a lack of prospective, experimental research. Better understanding whether reducing UP food consumption results in symptoms of withdrawal can contribute to the development of more effective interventions and inform the scientific debate about whether UP foods should be considered addictive.

PI_NAMEs: GEARHARDT, ASHLEY NICOLE (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Abstinence;addiction;Adopted;Affective;Affective Symptoms;aged;American diet;Animal Model;associated symptom;attentional bias;biobehavior;Blood Glucose;Brain;Calories;Carrots - dietary;Chronic;Clinical;clinically significant;Cognitive;Consumption;cooking;craving;cue reactivity;Cues;design;Development;Diet;dietary;Dietary Practices;Disease;Distress;Eating;Ecological momentary assessment;Education;effective intervention;Elements;Engineering;Exhibits;experimental study;Failure;fast food;Food;food consumption;food craving;Goals;Heart Rate;high risk population;Human;Ice Cream;Individual;Industrialization;Intake;Intervention;Investigation;Maintenance;Marketing;Methods;mortality;Motivation;neural;Neurobehavioral Manifestations;novel;novel strategies;Nutrient;Obesity;Patient Self-Report;Pattern;Persons;physical symptom;Process;prospective;Public Health;Public Policy;reduced food intake;relapse prediction;Reporting;Research;response;Restaurants;Rewards;Rice;Risk;Science;Source;stress reactivity;stressor;Substance Use Disorder;success;symptom management;Symptoms;Testing;Time;Translational Research;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: A Biopsychobehavioral Investigation of Withdrawal from Ultra-Processed Food in Humans

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Mental Health;Prevention;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE The overall objective of this proposal is to collaboratively address dissemination and implementation gaps for PrEP care for cisgender women in Atlanta. Anchored in implementation science and community engagement, with a cross-sector clinic-academic-CBO collaboration, and innovatively blending the two through human centered design methods (HCD), we will a) prepare and evaluate tailored PrEP implementation strategies in Atlanta Title X clinics; b) use and evaluate an evidence-based community organizing approach to increase awareness and interest about PrEP and connection to PrEP care among women across Atlanta; and c) use innovative HCD methods to collaboratively engage community and Title X clinic sites to develop patient- centered, acceptable, and feasible PrEP care models for women. Given limited research pertaining to strategies to increase PrEP reach among cisgender women in the South, the findings from each of our aims will fill critical gaps and optimize clinic and community strategies to strengthen HIV prevention for women in the Southern US.

PI_NAMEs: SALES, JESSICA A (contact);SHETH, ANANDI NAYAN

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Affect;AIDS prevention;Area;Awareness;care delivery;care seeking;Caring;cis-female;cisgender;Client;Clinic;Collaborations;collaborative approach;Communities;community engaged approach;community engagement;community organizations;community partners;Contraceptive methods;Counseling;County;Coupled;Data;Development;Dissemination and Implementation;Ensure;Epidemic;evidence base;Family Planning;Family Planning Programs;Federally Qualified Health Center;Funding;Grant;High Risk Woman;HIV;HIV diagnosis;human centered design;Human immunodeficiency virus test;Human Papilloma Virus Vaccine;implementation research;implementation science;implementation strategy;improved;innovation;Interactive Systems Framework;interest;member;Methodology;Methods;Modeling;patient oriented;patient-level barriers;Patients;Positioning Attribute;pre-exposure prophylaxis;Prevention strategy;Process;Provider;provider-level barriers;Recommendation;Research;Sales;satisfaction;scale up;screening;Sexual Health;Side;Site;social stigma;System;Training;Trust;uptake;usability;Voice;Woman;women patients;Women's Health;women's prevention;Work

PROJECT_TITLE: An Interactive Systems Approach to Ending the HIV Epidemic Among Women in Atlanta


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE Child maltreatment is a significant public health issue affecting millions of youth and families every year. To date, there are no systematic training programs that address the need to expand child maltreatment science across the wide range of disciplines relevant to child maltreatment. The CMT32, using a transdisciplinary approach, will integrate training in child maltreatment across four tracks of training: biological embedding, developmental processes, prevention and treatment, and policy, administrative data systems to create pre and postdoc scholars who are fully equipped to contribute to the complex nature of child maltreatment science.

PI_NAMEs: JACKSON, YO ;SCHREIER, HANNAH MILENA CAROLINE (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: next generation;Science

PROJECT_TITLE: Creating the Next Generation of Scholars in CM Science (CMT32)


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: In this study, we will culture human PAX7::GFP+ skeletal muscle stem/progenitor cells on aligned, electrospun fibrin microfiber bundles to induce their fusion into myotubes and assembly into 3D skeletal muscle grafts. We will optimize the delivery of soluble and tethered agrin in combination with insulin-like growth factor-1 (IGF-1) to promote the growth and myogenic differentiation of PAX7::GFP+ cells. Subsequently, we will use skeletal muscle grafts engineered with and without soluble and tethered agrin/IGF-1 to promote neuromuscular regeneration and functional recovery in a murine model of volumetric muscle loss.

PI_NAMEs: GRAYSON, WARREN L (contact);LEE, GABSANG

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: 3-Dimensional;Acetylcholine;Action Potentials;Agrin;Binding;Biocompatible Materials;Biophysics;Blood Vessels;Cell Aggregation;cell growth;Cell Survival;Cell Therapy;Cells;Cellular Morphology;Cholinergic Receptors;Clinical;Data;Defect;Development;Economic Burden;effective therapy;Electrospinning;Engineering;Fiber;Fibrin;Fibrosis;Functional Regeneration;functional restoration;Gene Expression Profile;Genes;Genetic;Growth;Harvest;Heparan Sulfate Proteoglycan;Heterogeneity;Human;human pluripotent stem cell;immunodeficiency;Immunodeficient Mouse;Implant;In Vitro;in vivo;Individual;Infiltration;Injury;Insulin-Like Growth Factor I;Intercept;Kinetics;lean body mass;Modulus;monolayer;Morphology;Motor Neurons;mouse model;Mus;Muscle;Muscle Cells;Muscle Contraction;muscle engineering;Muscle Fibers;muscle grafts;muscle physiology;muscle progenitor cell;muscle regeneration;Muscular Atrophy;Myoblasts;myogenesis;Natural regeneration;Nerve;neural;neuromuscular;Neuromuscular Junction;neurotransmission;novel;Phenotype;Play;Population;Porosity;post-transplant;postsynaptic;Preparation;Prevention;progenitor;Proliferating;Property;Recovery of Function;regeneration potential;Regenerative capacity;reinnervation;repaired;Reporter;Role;scaffold;scale up;single-cell RNA sequencing;Site;Skeletal Muscle;Sorting;stem;stem cell biology;stem cells;Surgical incisions;Testing;tibialis anterior muscle;Tissue Engineering;Transplantation;Traumatic injury;Treatment Protocols;Vascularization;volumetric muscle loss

PROJECT_TITLE: Regenerating Vascularized and Innervated Skeletal Muscle to Treat VML Defects

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_DEPT: BIOLOGY

PHR: My laboratory is highly motivated to develop innovative research tools to solve challenging biological and biomedical problems as we have done in the past and will be doing in the future. Currently, we aim at developing a new microscopy imaging technique termed enhanced photon microscopy and solving critical questions in two transport mechanisms: 1) mapping disordered protein motifs in the nuclear pore complex; and 2) tracking membrane proteins transport from cytoplasm to primary cilium.

PI_NAMEs: YANG, WEIDONG  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: 3-Dimensional;Amino Acid Motifs;base;Biological;Biophysics;Cell Nucleus;Cells;Cilia;Collection;Communication;Confocal Microscopy;Cytoplasm;Development;Disease;Eukaryotic Cell;fluorophore;Funding;Future;Grant;imaging system;Imaging Techniques;improved;innovation;Journals;Kinetics;Laboratories;Laser Scanning Confocal Microscopy;Link;macromolecule;Manuscripts;Maps;Mediating;Membrane;Membrane Transport Proteins;meter;Methods;microscopic imaging;Microscopy;Molecular Biology;Nature;Nuclear Envelope;Nuclear Pore Complex;nucleocytoplasmic transport;optical imaging;Optics;Organelles;Organizational Models;Photons;Positioning Attribute;protein transport;Proteins;Protocols documentation;Publishing;Research;Resolution;RNA;Route;Science;structural biology;superresolution microscopy;tool;trafficking;Transport Process;Work

PROJECT_TITLE: Super-resolution Microscopy Study of Molecular Transport Mechanisms

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE This project will investigate mammalian DNA polymerase theta, the defining enzyme for an important pathway that repairs genomic damage. It will help clarify how these Polymerase functions in repair and the contexts that engage it. Our work together will allow us to exploit the vulnerabilities that arise when this repair pathway is defective as a cancer therapy.

PI_NAMEs: RAMSDEN, DALE A (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Acute;Address;Biochemical;Biochemistry;Biological;Biological Assay;Biophysics;brca gene;Camptothecin;cancer cell;cancer therapy;Candidate Disease Gene;Cell Line;Cell Proliferation;Cell Survival;Cells;Cellular Assay;Cellular biology;Chromosome abnormality;Collaborations;Complex;Core Facility;Core Protein;design;Development;Disparate;DNA Damage;DNA Repair;DNA replication fork;DNA-Directed DNA Polymerase;Double Strand Break Repair;enzyme activity;Enzymes;established cell line;experimental study;Feedback;Fertilization;Fostering;Frustration;Genes;Genetic;Genetic study;Genomic Instability;Genomics;Goals;Hereditary Breast Carcinoma;homologous recombination;Human;imaging approach;Imaging Techniques;inhibitor;insight;Knowledge;Length;Malignant Neoplasms;Measures;Mediating;Methods;Modeling;Molecular;Molecular Biology;Monitor;mutant;Mutation;Names;Nonhomologous DNA End Joining;Normal Cell;novel;Pathway interactions;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;Productivity;Program Research Project Grants;programs;protein purification;Proteins;Radiation;Reagent;reconstitution;repaired;Research;response;Role;single molecule;small molecule;small molecule inhibitor;structural biology;Structural Models;Variant;Visualization;Wood material;Work

PROJECT_TITLE: Polymerase theta, genome instability, and cancer


PHR: PROJECT NARRATIVE This project will investigate mammalian DNA polymerase theta, the defining enzyme for an important pathway that repairs genomic damage. Project 1 (this project) will help clarify mechanism and biological role of this pathway as part of a multidisciplinary program project; our work together will allow us to exploit the vulnerabilities that arise when this repair pathway is targeted as a cancer therapy.

PROJECT_TERMS: Acute;Biochemical;Biochemistry;Biological;Biological Assay;Biophysics;brca gene;Camptothecin;cancer therapy;candidate validation;cell growth;Cell Line;Cell Survival;Cells;Cellular Assay;chemotherapeutic agent;Chromosomal Breaks;Cicatrix;CRISPR screen;Defect;Development;DNA Damage;DNA Double Strand Break;DNA Repair Enzymes;DNA Repair Gene;DNA replication fork;DNA-Directed DNA Polymerase;Enzymes;experimental study;extrachromosomal DNA;Feedback;G22P1 gene;Genes;Genetic;Genetic Epistasis;Genetic Screening;Genome;genome-wide;Genomic Instability;Genomics;High-Throughput Nucleotide Sequencing;homologous recombination;In Vitro;Inherited;interest;Knowledge;Link;live cell imaging;Malignant Neoplasms;Mediating;Mediator;member;Methods;Molecular;Molecular Biology;Monitor;multidisciplinary;mutant;Mutate;Names;Nonhomologous DNA End Joining;Normal Cell;novel;Nucleotides;p53-binding protein 1;Pathway interactions;Play;Poison;Polymerase;programs;protein purification;Rationalization;reconstitution;repaired;Research;response;Role;SET gene;single molecule;structural biology;superresolution microscopy;targeted cancer therapy;Testing;TOP1 gene;Variant;whole genome;Work

PROJECT_TITLE: Cellular requirements for Pol theta function


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: Project Narrative  This proposal is centered on the hypothesis that cardiac ischemia induces biosynthesis of a group of atypical, toxic sphingolipids that promote cardiomyocyte death. Our evidence indicates ischemia in humans and mouse models upregulates Sptlc3, a novel subunit of serine palmitoyltransferase (SPT), that shifts the substrate preference of SPT, leading to accumulation of atypical, toxic sphingolipids. We will explore whether cardiomyocyte-specific depletion of Sptlc3 attenuates cardiac pathology arising from acute and chronic ischemia in vivo, determine the mechanisms of Sptlc3 regulation, identify specific atypical sphingolipids produced, and determine the cell mechanism(s) by which Sptlc3 products induce apoptosis.

PI_NAMEs: COWART, LAUREN ASHLEY (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Ablation;Acute;Acyl Coenzyme A;Address;Affect;Alleles;Amino Acids;Anabolism;Apoptosis;Apoptotic;Attenuated;Autophagocytosis;base;Biochemical;Carbon;Cardiac;Cardiac Myocytes;Cardiovascular alteration;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cell model;Cell Physiology;cell type;Cells;Ceramides;Cessation of life;Characteristics;Chronic;Coenzyme A;Complex;Coupled;Cytosol;Data;diabetic cardiomyopathy;Diabetic mouse;Dihydrosphingosine;Dimerization;Disease;Enzymes;Eukaryotic Cell;Event;fibrogenesis;Foundations;functional group;General Population;Generations;Genetic Transcription;genomic locus;Glycosphingolipids;Heart;Heart failure;heart function;Heart Injuries;Homeostasis;Human;human model;improved;In Vitro;in vivo;Induction of Apoptosis;Infarction;Inflammation;innovation;inorganic phosphate;insight;Ischemia;ischemic cardiomyopathy;ischemic injury;Lipids;LoxP-flanked allele;Mass Spectrum Analysis;Messenger RNA;Metabolic Pathway;Metabolism;Modeling;mouse model;Mouse Strains;Mus;Myocardial;Myocardial dysfunction;Myocardial Ischemia;Myocardium;novel;Outcome;Palmitates;Palmitoyl Coenzyme A;Pathologic;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Physical condensation;Physiological;Play;Post-Transcriptional Regulation;preference;prevent;Production;programs;Property;Proteins;Publishing;Reaction;Regulation;Research;response;Role;scaffold;Scheme;Serine;serine palmitoyltransferase;Signal Transduction;Single Nucleotide Polymorphism;Sphingolipids;Sphingomyelins;sphingosine 1-phosphate;Stress;Structure;Techniques;Testing;Therapeutic;Therapeutic Intervention;tool;TP53 gene;transcription factor;Up-Regulation;Vertebral column;Work

PROJECT_TITLE: Novel sphingolipid metabolites in myocardial ischemia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-L(02)]


NIH_SPENDING_CATS: Cancer;Genetics

PHR: PROJECT NARRATIVE This project will investigate mammalian DNA polymerase theta, the defining enzyme for a biologically important mechanism for repair of genomic damage. This Project is part of a multidisciplinary program project that will uncover vulnerabilities that arise when this repair process is defective. This research is directly relevant to the future of successful pol theta-based therapies.

PI_NAMEs: WOOD, RICHARD D (contact)

PROJECT_TERMS: base;Biochemical;Biochemistry;Biological;Biophysics;BRCA1 gene;Camptothecin;cancer therapy;Cell Line;Cells;Cellular Assay;clinically relevant;Collaborations;Data;Defect;design;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Insertion Elements;DNA Ligases;DNA Polymerase Inhibitor;DNA Repair Enzymes;DNA-Directed DNA Polymerase;Enzymes;Excision;experimental study;Feedback;Future;Genes;Genetic;Genomic Instability;Genomics;helicase;High-Throughput DNA Sequencing;Human;Image;in vivo;inhibitor;Ionizing radiation;Knowledge;Length;Location;Malignant Neoplasms;Mammalian Cell;Mediating;Modeling;Molecular;Molecular Biology;Monitor;multidisciplinary;Mutate;Mutation;nuclease;Outcome;Outcome Study;PARP inhibition;Pathway interactions;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;pre-clinical;Process;programs;protein purification;Proteins;Radiation;Reaction;reconstitution;repaired;Research;Resected;response;Role;small molecule inhibitor;SS DNA BP;structural biology;Structure;synthetic construct;Tail;tool;tumor;Variant;Visualization;Work

PROJECT_TITLE: Biochemical reconstitution and inhibition of TMEJ


NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE This project combines state-of-the-art expertise in machine learning and neural signal processing to develop technology for detection, characterization, and validation of electrophysiological biomarkers of clinical improvement in patients receiving responsive neurostimulation for drug-resistant epilepsy.

PI_NAMEs: RICHARDSON, ROBERT MARK (contact)

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: Acceleration;Adult;attenuation;Biological Markers;biomarker validation;brain computer interface;Categories;Child;Childhood;Chronic;Clinical;clinical care;Clinical Trials;cohort;Computer software;convolutional neural network;Data;Data Analytics;Data Set;Databases;deep learning;Detection;Devices;Electric Stimulation;Electroencephalography;Electrophysiology (science);Epilepsy;epileptiform;Event;Exhibits;FDA approved;Frequencies;Implant;implantable device;improved;Individual;individual patient;Intractable Epilepsy;Knowledge;Label;Machine Learning;Maintenance;Methods;Neural Network Simulation;neurophysiology;neurotransmission;novel;Outcome;Patient Outcomes Assessments;Patient Self-Report;Patients;Pattern;pediatric patients;Performance;Pharmaceutical Preparations;Phase;Prediction of Response to Therapy;predictive marker;premature;prevent;Property;Records;Reporting;response;response biomarker;Seizures;Series;signal processing;Signal Transduction;System;Techniques;Technology;Therapeutic;Time;tool;treatment optimization;treatment response;Validation;Visual;Work

PROJECT_TITLE: Electrographic Seizure Pattern Modulation Biomarkers in Responsive Neurostimulation for Epilepsy

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

PHR: PROJECT NARRATIVE This project will investigate the structure and activity of mammalian DNA polymerase theta, the defining enzyme for an important process for repair of genomic damage. This Project is part of a multidisciplinary Program Project which will uncover vulnerabilities that arise when DNA polymerase theta is defective. This research is directly relevant to the future of successful Pol theta-based cancer therapeutics.

PI_NAMEs: DOUBLIE, SYLVIE  (contact)

PROJECT_TERMS: Architecture;ATP phosphohydrolase;Binding;Biochemical;Biological;Biological Assay;biophysical techniques;Bypass;Caenorhabditis elegans;cancer therapy;carcinogenesis;Cell Line;Cells;Chimeric Proteins;Complex;design;Dimerization;DNA;DNA analysis;DNA Binding;DNA Damage;DNA Double Strand Break;DNA Repair Enzymes;DNA-Directed DNA Polymerase;Electron Microscopy;Elements;Enzymes;Evaluation;Exonuclease;experimental study;Feedback;Future;Genomic Instability;Genomics;helicase;In Vitro;insight;Kinetics;Knowledge;Laboratories;Length;Link;Malignant Neoplasms;Mammalian Cell;Mediating;Methods;Molecular;molecular imaging;Monitor;multidisciplinary;mutant;Mutation Analysis;nuclease;Nucleotides;paralogous gene;Pathway interactions;Play;Polymerase;Process;programs;Property;Protein Engineering;protein purification;Proteins;reconstitution;repaired;Research;Roentgen Rays;Role;single molecule;Site;Specificity;structural determinants;Structure;Substrate Interaction;targeted cancer therapy;Testing;Therapeutic;Variant;Work

PROJECT_TITLE: Structural determinants of Pol theta function


PHR: PROJECT NARRATIVE The limitations in our understanding of polymerase theta protein functions directly affect our approaches to the treatment of human cancers. This project is highly significant because it examines complex levels of polymerase theta meditated repair that have relevance to aberrant DNA repair and replication in cancer. Our proposal addresses key issues that are directly related to therapeutic response and resistance in cancer.

PI_NAMEs: ROTHENBERG, ELI  (contact)

PROJECT_TERMS: Address;Affect;Biochemical;Biochemistry;Biological;Biological Assay;Biophysics;Camptothecin;cancer cell;Cell Line;Cells;Cellular Assay;Chromosomal Breaks;Chromosome Pairing;Collaborations;Complex;Data;Defect;design;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Enzymes;DNA replication fork;DNA Structure;DNA-Directed DNA Polymerase;Exclusion;Experimental Designs;experimental study;Feedback;Genomic Instability;helicase;Human;Human Cell Line;In Vitro;Individual;innovation;Kinetics;Knowledge;Length;Malignant Neoplasms;Mammalian Cell;Maps;Measurement;Measures;Mediating;Meditation;Molecular;Molecular Biology;Monitor;mutant;Mutation;Nonhomologous DNA End Joining;novel;p53-binding protein 1;Pathway interactions;Patients;Polymerase;Process;programs;Property;protein function;protein purification;Proteins;Rationalization;Reaction;Recombinant Proteins;reconstitution;recruit;Regulation;repaired;Research;Role;single molecule;Site;structural biology;Structure;superresolution microscopy;System;Techniques;Testing;therapy resistant;timeline;tool;treatment response;tumor;Variant;Visualization;Wood material;Work

PROJECT_TITLE: Single-molecule studies of Theta mediated end joining


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative: The proposed research is relevant to public health because it will advance the toolkit used in discovery science for high yield early phase target validation and therapeutic screening for the development of new treatments for mental health disorders. By understanding how local impairments alter systems-level network function in relation to a clinically relevant cognitive test used for human neuropsychological assessment, it will be possible to promote the development of interventions that improve the health and wellbeing of individuals with mental illness and meet the mission of the NIMH.

PI_NAMEs: BURKE, SARA N;MAURER, ANDREW PORTER (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Address;Affect;Affective;analog;Animal Model;Animals;Anxiety;autism spectrum disorder;Behavior;Behavior assessment;behavior measurement;Behavioral;behavioral outcome;Biological Assay;Biological Markers;Bipolar Disorder;Brain;cholinergic;Clinical;Clinical Trials;clinically relevant;Cognition;cognitive function;cognitive process;cognitive testing;Communication;comparative;Coupling;Data;density;design;designer receptors exclusively activated by designer drugs;Development;diagnostic tool;drug discovery;drug efficacy;drug testing;Elderly;Electroencephalography;emotion regulation;Evaluation;experimental study;Failure;Foundations;Funding;Funding Opportunities;Goals;Health;Heart Diseases;high throughput screening;Hippocampus;Human;Impaired cognition;Impairment;improved;in vivo;Individual;innovation;Knowledge;Link;Malignant Neoplasms;Mammals;Measures;mental development;Mental disorders;Mission;Modeling;National Institute of Mental Health;neural;Neurobiology;Neurons;neurophysiology;Neuropsychological Tests;Neuropsychology;Neurotransmitters;novel;novel diagnostics;novel therapeutics;Outcome;Paired-Associate Learning;Parietal;Performance;Personal Satisfaction;pharmacologic;Pharmacologic Substance;Pharmacological Treatment;Phase;Physiological;pre-clinical;predictive marker;Prefrontal Cortex;Psychiatric therapeutic procedure;Psychiatry;Public Health;Research;Rodent;Schizophrenia;Science;screening;Screening procedure;Series;Severities;Severity of illness;Surface;System;Task Performances;Technology;Temporal Lobe;Testing;Therapeutic;therapeutic development;therapeutic target;therapy development;touchscreen;Translating;Traumatic Brain Injury;treatment optimization;Validation

PROJECT_TITLE: Preclinical Assays of Hippocampal-Prefrontal Cortical Circuit Engagement for Application in Therapeutic Development

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: Communication;conflict resolution;Elements;Ensure;Genomic Instability;Goals;Human Resources;Institution;Malignant Neoplasms;meetings;member;Monitor;New York;North Carolina;Office of Administrative Management;operation;performance site;Policies;Polymerase;Preparation;programs;Progress Reports;recruit;Regulation;Research;Research Personnel;Resources;Rotation;Services;Site;Teleconferences;Texas;United States National Institutes of Health;Vermont

PROJECT_TITLE: Administrative core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE One limitation to fight off persistent viruses is the poor knowledge on the factors that could promote immunity in the context of the inhibitory environment that characterizes chronic viral infections. We have identified cytokine and microbiota positive effects on viral control in a murine model of persistent infection. We propose to study the mechanisms involved in order to best harness these factors to prevent or attenuate viral persistence.

PI_NAMEs: ZUNIGA, ELINA I (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acceleration;Anti-viral Response;Antibodies;Antibody Response;Antibody-mediated protection;Antigens;Attenuated;Automobile Driving;B-Lymphocytes;Bacteria;Biological Models;Biological Response Modifiers;Biology;burden of illness;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Survival;Cells;Cessation of life;Chronic;chronic infection;Clostridium;cytokine;Data;Development;Distal;Docosahexaenoic Acids;Elements;Environment;exhaustion;Exhibits;Farm;fighting;Goals;Hepatitis B Virus;Hepatitis C virus;HIV;Host Defense;host microbiota;Human;Immune;Immune response;Immune System Diseases;Immunity;immunoregulation;in vivo;Infection;interleukin-21;Interleukin-6;Knowledge;Laboratories;Lymphocytic choriomeningitis virus;metabolomics;microbiome;microbiota;mouse model;Mus;nonhuman primate;pathogen;Pathway interactions;Phylogenetic Analysis;prevent;Production;progenitor;programmed cell death protein 1;programs;receptor;Regulation;Reporting;Research;resident commensals;Rodent;Role;Serum;Site;Small Intestines;Specificity;T cell differentiation;T cell response;T-Lymphocyte;Testing;The Jackson Laboratory;Therapeutic;Viral;Virus;Virus Diseases

PROJECT_TITLE: Positive Immune-regulators During Chronic Viral Infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-R(02)]


NIH_SPENDING_CATS: Bioengineering;Cancer

PHR: NARRATIVE The Protein Expression and Purification Core (Core B) will play an integral role in the Program Project by providing purified proteins to all projects, in a cost-effective manner. The proposed studies are expected to advance our understanding of the role of human DNA Polymerase θ in genome instability and cancer.

PROJECT_TERMS: Adherent Culture;Affinity Chromatography;Biochemical;Biochemistry;Biophysics;Cell Line;Cells;Cellular Assay;Charge;Complex;Core Facility;cost effective;Crystallization;Dedications;DNA-Directed DNA Polymerase;Engineering;Escherichia coli;experience;experimental study;Gel Chromatography;Genomic Instability;Goals;Human;human DNA;Human Resources;in silico;Incubators;Individual;Ion Exchange;Length;light scattering;Liquid substance;Malignant Neoplasms;Mammalian Cell;Mediating;Methods;Microscope;Molecular;Molecular Biology;Play;Polymerase;Production;programs;Property;protein aggregation;protein expression;protein purification;Proteins;Proteolysis;Protocols documentation;Quality Control;Reagent;repaired;Research;Research Personnel;Robotics;Role;Secure;Sequence Alignment;Services;single molecule;Site;Sodium Chloride;Solubility;Solvents;structural biology;success;Suspension Culture;System;Tertiary Protein Structure;tissue culture;Universities;Variant;vector;Wood material;Work

PROJECT_TITLE: Protein Expression and Purification


PHR: PROJECT NARRATIVE This project will investigate mammalian DNA polymerase theta, the defining enzyme for a biologically important mechanism for repair of genomic damage. This Core will generate and validate mammalian cell line reagents that are vital for a multidisciplinary program project that will uncover vulnerabilities that arise when this repair process is defective. This research is directly relevant to the future of successful polymerase theta-based therapies.

PI_NAMEs: GUPTA, GAORAV P. (contact)

PROJECT_TERMS: Aliquot;Alleles;Biological Assay;Cell Line;Cells;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;cost effectiveness;Credentialing;CRISPR/Cas technology;Cryopreservation;design;digital;DNA Double Strand Break;DNA Repair Enzymes;DNA-Directed DNA Polymerase;Doxycycline;empowerment;Engineering;Ensure;Enzymes;Experimental Designs;experimental study;Future;Gene Targeting;Generations;Genes;Genetic Engineering;genetically modified cells;Genome;Genome engineering;Genomic Instability;Genomics;Genotype;Goals;homologous recombination;Human;In Vitro;in vivo;interest;Karyotype;Karyotype determination procedure;Knock-in;Knock-out;laboratory experiment;Ligands;Malignant Neoplasms;Mammalian Cell;Manuscripts;Mediating;Methods;Modeling;Monitor;multidisciplinary;Mus;Mutagens;Mycoplasma;overexpression;parity;Polymerase;Process;programs;protein expression;Proteins;Protocols documentation;Publications;quality assurance;Quality Control;Reagent;repaired;repository;Reproducibility;Research;Research Activity;Research Personnel;Role;screening;Secure;service programs;Services;Standardization;success;synergism;System;Testing;Time;transcriptome sequencing;Transfection;transgene delivery;transgene expression;Transgenes;Validation;vector

PROJECT_TITLE: Cell line Core


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cancer;Immunotherapy;Lung;Lymphatic Research;Rare Diseases;Tuberous Sclerosis;Women's Health Research

ORG_DEPT: DERMATOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: NARRATIVE We will prepare transgenic T cells targeting melanoma-associated antigens, and optimize their attributes for effective targeting of cells responsible for tumor nodule formation in lymphangioleiomyomatosis (LAM). Efficacy testing in vitro and in vivo will be accompanied by state-of-the-art immune monitoring, with the objective of developing a safe and effective approach to eliminating LAM lesions.

PI_NAMEs: LE POOLE, I. CAROLINE (contact);NISHIMURA, MICHAEL I.

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Adoptive Cell Transfers;Adoptive Transfer;Affect;Alleles;Antibodies;Antigens;Automobile Driving;Benign;CCL2 gene;Cell Compartmentation;cell preparation;Cells;Cellular immunotherapy;chemokine;chemokine receptor;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Trials;Complex;cytokine;cytotoxicity;Data;design;Development;Diagnostic;Disease;disease model;Distant;Educational process of instructing;effective therapy;effector T cell;efficacy testing;engineered T cells;Environment;Epitopes;Exhibits;Exposure to;Female of child bearing age;Follow-Up Studies;FRAP1 gene;Gene Expression Profile;Genes;Glycoproteins;gp100 Antigen;Homing;Human;human model;Immune;immune cell infiltrate;Immunocompetent;immunogenic;Immunologic Monitoring;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Implant;improved;in vitro activity;in vitro testing;in vivo;Infiltration;insight;Investigation;Learning;Lesion;Life Expectancy;Ligands;Longevity;Lung;Lung Lymphangioleiomyomatosis;Lung Transplantation;Lymphangioleiomyomatosis;Macrophage;Malignant Neoplasms;Measures;Melanoma;melanoma-associated antigen;Memory;migration;Modality;Modeling;Monitor;monocyte chemoattractant protein 1 receptor;mouse model;Mus;Mutation;Nature;neoantigens;neoplasm immunotherapy;Neoplasm Metastasis;neoplastic cell;Nodule;Outcome;overexpression;patient derived xenograft model;Patients;permissiveness;pre-clinical;Predisposition;Rare Diseases;Reaction;Reagent;receptor;Regulatory T-Lymphocyte;Renal Tissue;Reproducibility;Safety;side effect;Signal Transduction;SILV gene;Sirolimus;Site;Solid;Sorting;Source;Specificity;stemness;Surface;Surface Antigens;T cell response;T cell therapy;T-Cell Homing Receptors;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Time;Tissues;tool;trafficking;Transgenic Mice;Transgenic Organisms;Treatment Efficacy;tumor;Tumor Antigens;tumor progression;tumor-immune system interactions;vector;Woman;women's diagnosis;young woman

PROJECT_TITLE: Time to ATTAC: Adoptive Transfer of T cells Against gp100+ Cells to treat LAM

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The Penn Center for Musculoskeletal Disorders (PCMD) will continue to provide critical resources and programs to, and enhance research productivity of, investigators to address multidisciplinary research strategies for musculoskeletal problems. The overall goal of this Center is to promote cooperative interactions among investigators, accelerate and enrich the effectiveness and efficiency of ongoing research, foster new collaborations and new research, and ultimately, translate our research efforts into better and new therapies for musculoskeletal disorders. Our PCMD is the home for musculoskeletal research across the Penn campus and a hub for the musculoskeletal community across the region and neighboring states .

PI_NAMEs: SOSLOWSKY, LOUIS J (contact)

PROGRAM_OFFICER_NAME: GARCIA-CAZARIN, MARY

PROJECT_TERMS: Acceleration;Address;Advocate;analytical tool;Animal Model;Animals;Area;assay development;Awareness;Biological Assay;Biomechanics;Biomedical Research;blood vessel development;bone;Cartilage;clinically significant;Collaborations;Communication;Communities;Core Facility;cost;Development;Diagnosis;Discipline;Disease;disorder prevention;Education;Effectiveness;endogenous stem cells;experimental study;Extramural Activities;Fostering;Funding;Goals;Grant;healing;Histology;Home;Housing;Human;human disease;Image;Imaging technology;in vivo;Individual;Inflammation Mediators;Injury;injury and repair;innovation;Institution;Interdisciplinary Study;Knock-out;Knowledge;Laboratories;Leadership;Learning;Length;Ligaments;member;Meniscus structure of joint;Mentorship;Methods;Modeling;Molecular;multidisciplinary;Mus;Muscle;Musculoskeletal;Musculoskeletal Development;Musculoskeletal Diseases;musculoskeletal disorder therapy;musculoskeletal injury;Musculoskeletal System;Natural regeneration;novel strategies;novel therapeutics;Phenotype;pre-clinical;Procedures;Productivity;programs;Rattus;repaired;Research;Research Personnel;Resources;Stem Cell Mobilization;success;System;Techniques;Tendon structure;Testing;therapeutic development;Tissues;tool;trait;Transgenic Organisms;Translating;translational model;translational study;Voice;Work

PROJECT_TITLE: Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)


PROJECT_TERMS: Acceleration;Address;Advocacy;Animal Model;assay development;Biomedical Research;bone;Cartilage;clinically significant;Collaborations;Communication;Communities;Discipline;Disease;Doctor of Philosophy;Effectiveness;Faculty;Financial Support;Floor;Fostering;Funding;Goals;Grant;Home;Human;Individual;Information Networks;injury and repair;Institution;Interdisciplinary Study;Knowledge;Leadership;Ligaments;member;Meniscus structure of joint;Monitor;multidisciplinary;Muscle;Musculoskeletal;Musculoskeletal Development;Musculoskeletal Diseases;musculoskeletal disorder therapy;novel therapeutics;Pennsylvania;Philadelphia;pre-clinical;Procedures;Productivity;programs;recruit;Reporting;Research;Research Activity;Research Design;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Role;Services;Structure;success;Tendon structure;tissue injury;tissue repair;Tissues;tool;Translating;translational model;Universities;Voice

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative This application proposes to determine the structure and dynamics of ligand-free and antibody-bound SARS-CoV-2 S protein in the context of virus particles, and determine the fate of antibody-bound virus in vivo. Our work will inform active and passive immunization strategies against the COVID19 pandemic.

PI_NAMEs: MOTHES, WALTHER H (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;ACE2;Active Immunization;Address;Affect;Alveolar Macrophages;Antibodies;Antibody-mediated protection;Antigens;B-Lymphocytes;Binding;Cathepsins;Cells;Clinical Trials;Coronavirus;COVID-19;COVID-19 mortality;COVID-19 pandemic;Cryo-electron tomography;Cryoelectron Microscopy;Diagnostic Reagent Kits;dimer;Endosomes;Epitopes;Equilibrium;experimental study;Fluorescence Resonance Energy Transfer;Glycoproteins;Herd Immunity;Imaging Techniques;in vivo;in vivo imaging;Individual;Inflammatory Response;insight;Laboratories;Ligands;Mediating;Methods;Molecular Conformation;Monitor;mouse model;Mus;neutralizing antibody;nonhuman primate;particle;Passive Immunization;Pathogenicity;Patients;Peptide Hydrolases;Predisposition;preference;Preparation;Process;Protein Dynamics;Proteins;receptor;receptor binding;Respiratory System;response;Sampling;SARS coronavirus;SARS-CoV-2 immunity;SARS-CoV-2 spike protein;single molecule;Structure;Structure of parenchyma of lung;Surface;temporal measurement;Tissues;TMPRSS2 gene;Tropism;vaccination strategy;vaccine development;vaccine trial;Vaccines;Viral;Virion;Virus;Work

PROJECT_TITLE: Structure and Dynamics of the SARS-CoV-2 Spike Protein

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Women's Health Research

PHR: PROJECT NARRATIVE Women suffer more from Alzheimer’s disease (AD) than men, as shown by higher levels of tau – one of the hallmark brain changes in AD. Because sex hormones represent potential underlying causes of such sex differences, here we aim to understand the role of testosterone – a major sex hormone existing in both sex – in female mice that develop tauopathy. Results from this project will provide a direct physiological link between a sex hormone and tau pathogenesis, and guide hormone-based therapies against AD for both sexes.

PI_NAMEs: CHEN, XU  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease risk;Androgen Receptor;Androgens;Animals;Anti-Inflammatory Agents;Apolipoprotein E;Apolipoproteins;Astrocytes;Biology;Brain;brain cell;capsule;cell type;Cerebrospinal Fluid;Clinical;clinical application;Clinical Data;Cognitive deficits;cognitive function;Collaborations;Compensation;conditional knockout;Data;Deposition;Development;Disease;Disease Pathway;effective intervention;effective therapy;Estrogens;Female;Functional disorder;Gene Expression;Genetic;genetic manipulation;Goals;Gonadal Steroid Hormones;high risk;Hormones;Human;Impaired cognition;improved;Inflammation;insight;Intervention;Knock-in;Knock-in Mouse;Knowledge;Link;Literature;male;Mediating;men;Metabolism;Microglia;Modeling;Molecular;mouse model;Mus;Neurodegenerative Disorders;neuroimaging;neuroinflammation;neuronal survival;Neurons;neuroprotection;Neurosecretory Systems;novel;Operative Surgical Procedures;Outcome;Ovariectomy;Pathogenesis;Pathologic;Pathology;Pathway interactions;pharmacologic;Physiological;precision medicine;preclinical study;Progesterone;programs;protective effect;Publishing;Receptor Signaling;receptor-mediated signaling;Regulation;Reporting;Reproductive Biology;reproductive senescence;Research;Research Personnel;response;Risk Reduction;Role;sex;Sex Differences;Signal Transduction;single nucleus RNA-sequencing;Stanolone;subcutaneous;Supplementation;Synapses;tau aggregation;tau Proteins;tau-1;Tauopathies;Testosterone;Therapeutic;therapeutic target;transcriptome;transcriptomics;Transgenic Mice;Translational Research;Woman;Work

PROJECT_TITLE: Role of Testosterone in Modulating Tau Pathogenesis in Females

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Bioengineering;Rehabilitation

PI_NAMEs: MAUCK, ROBERT L (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Aging;Anisotropy;Biological;Biological Assay;biomechanical test;Biomechanics;Collaborations;Communities;Data;Dependence;Development;Disease;Doctor of Philosophy;E-learning;Education;Environment;experience;Floor;functional outcomes;Funding;Growth;Home;Imaging technology;improved;Injury;injury and repair;innovation;Knowledge;Length;Location;loss of function;mechanical load;Mechanics;member;Methodology;Methods;Molecular;Molecular Biology;Motion;Multiscale Mechanics;Musculoskeletal;Musculoskeletal Diseases;Natural regeneration;novel;novel strategies;novel therapeutics;Pennsylvania;Philadelphia;Physiology;Process;Productivity;programs;Research;Research Personnel;Resources;Role;Services;Techniques;Therapeutic;therapeutic development;Time;Tissues;Training;translational study;Universities;viscoelasticity

PROJECT_TITLE: Biomechanics Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Mental Health;Mental Illness;Neurosciences;Pediatric

PHR: Project Narrative Understanding changes in the brain that occur during the transition from adolescence to adulthood is critical for informing how major mental illness such as schizophrenia, mood disorders, substance use disorders, and others emerge at this time. Past studies, primarily in animals and in postmortem human brains, indicate a normative decrease of neural connections that is critical for refining brain communication and determining adult trajectories. We propose to use state of the art brain imaging and genetic approaches to delineate how the brain refines from adolescence to adulthood to support maturation of cognition, a critical first step for discerning what goes awry in psychopathology.

PI_NAMEs: LUNA, BEATRIZ  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;Adult;age related;Animals;Autopsy;Axon;bone;Brain;Brain imaging;Childhood;Cognition;Cognitive;cognitive control;cognitive development;cognitive process;cohort;Communication;Corpus striatum structure;critical period;Dendrites;density;design;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Dopamine;Electroencephalography;Epiphysial cartilage;Excitatory Synapse;executive function;First Degree Relative;Functional Magnetic Resonance Imaging;Gene Expression;Gene Expression Regulation;genetic approach;Glutamates;Grant;Human;Image;imaging approach;Impairment;in vivo;indexing;innovation;Iron;Life;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Magnetic Resonance Spectroscopy;Major Mental Illness;Measures;Mediating;Metabolic;Methodology;microRNA biomarkers;MicroRNAs;Mood Disorders;Morphology;multimodal neuroimaging;multimodality;Myelin;myelination;neural;Neurites;neurobiological mechanism;Neurobiology;Neurocognition;Neurocognitive;neuroimaging;neuromechanism;Neurons;Neurotransmitters;Noise;Participant;Peripheral;phosphodiester;Phospholipids;phosphomonoester;Phosphorus;Prefrontal Cortex;Process;Psychopathology;Puberty;rapid growth;Resolution;Rest;Role;Salivary;Schizophrenia;Short-Term Memory;Signal Transduction;Substance Use Disorder;Synapses;Synaptic plasticity;synaptic pruning;Synaptic Transmission;synaptogenesis;System;Testing;Time;Tissues;transition to adulthood

PROJECT_TITLE: Refinement of Brain Mechanisms Underlying the Developmental Stabilization from Adolescent to Adult Neurocognitive Processing

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Emergency Care;Health Services;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Pulmonary Fibrosis;Rare Diseases

PHR: Project Narrative Our interdisciplinary team of engineers, data scientists, and clinicians are developing a wearable device that can analyze odors from the skin. Using data from this new wearable device, we will develop algorithms to detect and monitor a variety of diseases and conditions, including skin diseases/conditions (e.g., psoriasis), emergency diseases/conditions (e.g., stroke), pulmonary diseases/conditions (e.g., asthma), and pediatric diseases/conditions (e.g., diabetic ketoacidosis). Because people will simply wear the small device, it can be used in a variety of settings like point-of-care, homes, and workplaces.

PI_NAMEs: FAN, XUDONG  (contact);GUDJONSSON, JOHANN ELI;GUNNERSON, KYLE JEROME;HUANG, YVONNE JEAN;MAHAJAN, PRASHANT

PROGRAM_OFFICER_NAME: CROUCHER, LEAH TOLOSA

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Age;Air;Algorithms;Ambulatory Care Facilities;Asthma;Atopic Dermatitis;autoencoder;Bluetooth;Bronchiectasis;Cardiovascular Diseases;Cellular Phone;Charge;Childhood;Chronic Disease;Chronic Obstructive Pulmonary Disease;Classification;Clinical;cohort;Column Chromatography;Congestive Heart Failure;cost;Coupled;Cutaneous;Cystic Fibrosis;Data;data exchange;Data Science;Data Scientist;deep learning;denoising;Dermatology;Detection;Devices;Diabetic Ketoacidosis;Diagnosis;Diagnostic;dimension reduction;Disease;Dryness;Electrical Engineering;Elements;embolic stroke;Emergency Medicine;Emergency Situation;Engineering;Enrollment;Ensure;Environment;environmental change;Evaluation;Excision;experience;Exposure to;Fibrosis;fibrotic interstitial lung disease;flexibility;Frequencies;Gas Chromatography;Gases;Gastrointestinal Hemorrhage;Gender;graphene;Health system;heart rate variability;Hemorrhage;Hidradenitis Suppurativa;Home;Hospitals;Hour;Humidity;Hydrophobicity;idiopathic pulmonary fibrosis;Inflammatory;Inflammatory Bowel Diseases;Inherited;Injections;Inpatients;instrument;Ions;Keratosis Follicularis;Laboratories;laptop;Light;light weight;Lithium;Lung;Lung Diseases;Measurement;medical specialties;Metabolic Diseases;Michigan;Microfabrication;Modeling;Molds;Monitor;multidisciplinary;nanoelectronics;Nervous System Disorder;neural network;Neural Network Simulation;Nose;Odors;operation;Participant;Patient Recruitments;Patients;Pattern;Pattern Recognition;Pediatrics;Performance;Persons;point of care;predictive modeling;Predisposition;Psoriasis;Pulmonology;Pyoderma Gangrenosum;Respiratory Disease;Sampling;sensor;Septic Shock;Series;Shapes;Sickle Cell Anemia;Skin;Skin Aging;skin disorder;Sorting;Specific qualifier value;Speed;Standardization;Stroke;Surface;Technology;Temperature;Time;Training;Tube;Universities;vapor;vector;Volatilization;voltage;Water;wearable device;Weight;Workplace

PROJECT_TITLE: High performance wearable body odor sensor arrays for disease detection and monitoring


PI_NAMEs: QIN, LING  (contact)

PROJECT_TERMS: Acute;Aging;Animal Model;base;Biological Assay;Biological Process;bone;Cartilage;Chronic;Collaborations;Communities;Consultations;Data;Data Analyses;Development;Disease;Doctor of Philosophy;Education;Ensure;Equipment;experience;extracellular;Faculty;Fibrocartilages;Floor;Foundations;Freezing;Funding;Health;Histologic;Histological Techniques;Histology;Home;human tissue;Image;Immunohistochemistry;In Situ Hybridization;injury and repair;innovation;Intervertebral disc structure;Laboratories;Ligaments;Location;Maintenance;Measurement;Mechanics;member;Methodology;mineralization;Muscle;Musculoskeletal;Musculoskeletal Diseases;novel;Paraffin;Pathologic;Process;programs;protocol development;Research;Research Design;Research Personnel;Resources;Sectioning technique;service delivery;Services;Stains;Structure;Techniques;Tendon structure;Tissue Engineering;Tissue Model;Tissue Sample;Tissues;tool;Training;Universities

PROJECT_TITLE: Histology Core