NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative This project aims to address the inequities in COVID-19 outcomes among persons involved with the criminal legal system (PCLS), characterized by lower testing and vaccination rates and more adverse outcomes relative to the general population. These disparities are influenced by the interaction of individual (e.g., underlying health conditions), structural (e.g., crowded detention facilities, limited healthcare accessibility during and after incarceration) and social network (e.g., medical mistrust, vaccine hesitancy) factors. Leveraging individual, structural and social network data from existing multisite RADx-UP studies and using innovative modeling approaches, this study aims to better understand these multifaceted interactions and identify interventions to improve COVID-19 testing and vaccination rates among PCLS and their communities.

PI_NAMEs: KHANNA, ADITYA SUBHASH (contact);MARTIN, ROSEMARIE A

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;adverse outcome;Affect;Attitude;Automobile Driving;barrier to care;Behavior;Biological Models;Common Data Element;Communities;Community Networks;community reentry;community setting;comparative;Complex;COVID-19;COVID-19 morbidity;COVID-19 mortality;COVID-19 outbreak;COVID-19 prevalence;COVID-19 prevention;COVID-19 testing;COVID-19 vaccination;Crowding;Data;data integration;Diffusion;Disparity;Drug Courts;dynamic system;Ensure;Environment;experience;Family;Friends;future pandemic;General Population;Graph;Health;Health behavior;health care availability;health disparity;Health Information System;Imprisonment;improved;Incidence;Individual;Inequity;Infection;infection rate;innovation;insight;Insurance;Intervention;intervention effect;Investigation;Jail;Legal;Legal system;Machine Learning;machine learning method;Medical;Minnesota;Misinformation;Modeling;Modernization;Morbidity - disease rate;mortality;network models;Outcome;parole;Pathway Analysis;peer;people of color;Persons;Policies;Population;Positioning Attribute;Prevention strategy;Preventive;Prisons;probation;RADx Underserved Populations;Resources;Rhode Island;Safety;Sampling;SARS-CoV-2 infection;SARS-CoV-2 transmission;Site;social health determinants;Social Network;social structure;Socioeconomic Status;structural determinants;Structural Racism;Structure;Study models;syndemic;System;Techniques;Testing;United States;uptake;US State;Vaccinated;Vaccination;vaccination outcome;vaccine acceptance;vaccine access;vaccine hesitancy;Vaccines;Vulnerable Populations;Washington

PROJECT_TITLE: Integrated Network Analysis of RADx-UP Data to Increase COVID-19 Testing and Vaccination Among Persons Involved with Criminal Legal Systems (PCLS)


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biotechnology;Physical Injury - Accidents and Adverse Effects

ORG_CITY: DURHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ORTHOPEDICS

ORG_FIPS: US

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE – PUBLIC HEALTH STATEMENT Advanced age diminishes bone repair capacity and is associated with increased surgical intervention at the time of the injury and subsequently due to the need for revisional surgery. Apolipoprotein E (ApoE) is a circulatory protein which we show to increase in abundance with age and to have deleterious effects in bone fracture healing. Here we propose to investigate the efficacy of using neutralizing antibodies temporally neutralize circulating ApoE to improve aged fracture healing and to identify the mechanism by which ApoE is able to inhibit bone repair and investigate the function of a newly identified osteoblastic cell-surface receptor, muscle-specific kinase (MuSK).

PI_NAMEs: BAHT, GURPREET  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Affect;Age;age related;aged;Aging;Antibodies;Apolipoprotein E;Biology;bone;bone aging;Bone callus;bone fracture repair;bone healing;Bone Marrow;Bone Regeneration;bone repair;Bone Tissue;Cell Culture Techniques;Cell surface;Cell Surface Receptors;Circulation;Clinic;clinical translation;cohort;cost;Data;Deposition;Dose;Elderly;Fracture;Health;healthcare burden;Hepatocyte;Human;Immunoglobulin G;Impairment;improved;In Vitro;inducible Cre;inhibitor;Injury;Intervention;knock-down;Ligands;Literature;Liver;LoxP-flanked allele;male;Malignant neoplasm of liver;Mechanics;mineralization;Modeling;Morbidity - disease rate;mortality;mouse Cre recombinase;mouse model;Mus;MUSK gene;Neuromuscular Junction;neutralizing antibody;novel;old mice;older adult;Operative Surgical Procedures;optimal treatments;Orthopedics;osteoblast differentiation;Osteoblasts;osteogenic;Outcome;Pathway interactions;Patients;Phenotype;Phosphorylation;Population;pre-clinical;prevent;progenitor;protein expression;Proteins;Public Health;Publishing;receptor;Receptor Protein-Tyrosine Kinases;Regimen;Reporting;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;siRNA delivery;Small Interfering RNA;Stromal Cells;Testing;Therapeutic;therapeutic target;therapy development;Time;tissue culture;Tissues;Transcript;Transgenic Mice;Translating;Treatment Protocols;Work

PROJECT_TITLE: A novel target in aged fracture healing

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Project Narrative Maintaining mitochondrial genomic integrity is necessary to protect against numerous pathologies, including age-related diseases. This proposal aims to highlight the underlying basis for the mitochondrial common deletion, a widespread aberrancy that cripples oxidative phosphorylation and is widespread in aging tissue. By studying the effects and underlying mechanisms of the mitochondrial common deletion, we hope to better understand how mitochondrial dysfunction contributes to age-related diseases.

PI_NAMEs: SFEIR, AGNEL  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: age-related disease;Aging;Base Pairing;Biogenesis;biological adaptation to stress;Brain;Cell Aging;Cell Physiology;cell type;Cells;Chronic progressive external ophthalmoplegia;dimer;DNA Repair;Drosophila genus;embryonic stem cell;Epithelial Cells;experience;Fibroblasts;Functional disorder;Genetic;Genome;genome integrity;Genome Stability;Genomic Instability;Germ Lines;heteroplasmy;insight;Interphase Cell;Kearns-Sayre syndrome;Link;Mammalian Cell;Methodology;Methods;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial dysfunction;mitochondrial genome;Mitosis;model organism;Monitor;Muscle;Muscle Cells;mutant;Mutate;Neurons;novel;Nuclear;Output;Oxidative Phosphorylation;particle;Pathology;Pathway interactions;Physiological;Positioning Attribute;postmitotic;prevent;Process;reconstitution;repaired;respiratory;response;Series;Somatic Cell;Specificity;Testing;Tissues;tool;transcription activator-like effector nucleases;transcriptomics

PROJECT_TITLE: Investigating the impact and dynamic of mitochondrial common deletion in somatic cells

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: TUSKEGEE INSTITUTE

ORG_DEPT: BIOLOGY

ORG_NAME: TUSKEGEE UNIVERSITY

ORG_STATE: AL

PHR: PROJECT NARRATIVE (Overall) This RCMI U54 application is from the existing, successful Tuskegee University (TU) Center for Biomedical Research Program that is committed to the elimination of health disparities in racial/ethnic minority and underserved populations in the ‘Deep South’, particularly among African Americans. By leveraging the distinct location of the center in the Alabama Black Belt and the historical mission of Tuskegee University dedicated to the education of minorities, we have build a health disparity focused program, whose mission is to understand the causes for these health disparities by supporting and enhancing diverse basic biological science, clinical health, and community-based research.

PI_NAMEs: BEDI, DEEPA  (contact);TURNER, TIMOTHY

PROGRAM_OFFICER_NAME: LAI, GABRIEL Y

PROJECT_TERMS: Address;Affect;African American population;Alabama;Applications Grants;Area;Behavioral;Behavioral Research;Bioethics;Bioinformatics;Biological Sciences;Biomedical Research;Biometry;Black race;career;career development;Clinical;Collaborations;collaborative environment;Communities;community based research;community engagement;community organizations;Community Outreach;Computational Biology;Core Facility;County;Dedications;Deep South;design;Development;Doctor of Philosophy;Education;Educational process of instructing;Educational workshop;empowerment;Environment;Ethnic Population;Evaluation;Exercise;Extramural Activities;Faculty;Fostering;Foundations;Funding;Goals;Health;Health Disparities Research;health disparity;health inequalities;Health Personnel;Heart;Human Resources;Infrastructure;Institution;instrumentation;inter-institutional;International;Learning;learning community;Location;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Maps;member;Mentors;Mentorship;Minority;Minority Groups;minority health;minority health disparity;Minority Health Research;minority scientist;minority student;Minority-Serving Institution;Mission;Molecular;multidisciplinary;National Institute on Minority Health and Health Disparities;Obesity;Outcome Assessment;outreach services;Population;Population Research;Positioning Attribute;Postdoctoral Fellow;Productivity;programs;racial disparity;racial minority;recruit;Research;research and development;research facility;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Science;Science, Technology, Engineering and Mathematics Education;Scientific Advances and Accomplishments;Scientist;Services;skills;Solid;STEM career;synergism;Training;Trust;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underserved Population;Universities;University adminstration;Vocational Guidance;Work;Workforce Development

PROJECT_TITLE: Tuskegee University Center for Biomedical Research/ RCMI


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: YATES, CLAYTON  (contact)

PROJECT_TERMS: Academic support;Address;Advisory Committees;Affect;African American population;Animals;Area;Award;Basic Science;Behavioral Research;Biomedical Research;Biomedical Technology;career;Collaborations;collaborative environment;Communication;community engagement;computer program;Contracts;Data Storage and Retrieval;Development;Disease;Disparity population;drug development;Educational Activities;Educational workshop;Ensure;Environment;Evaluation;experience;Extramural Activities;Faculty;Fostering;Funding;Funding Agency;Goals;Grant;Growth;Health;Health Disparities Research;health disparity;improved;Infrastructure;infrastructure development;Institution;Institutional Policy;Institutional support resources;Interdisciplinary Study;Knowledge;Laboratory Research;Mainstreaming;Maintenance;meetings;member;Minority Groups;minority scientist;Minority-Serving Institution;Molecular Biology;Monitor;multidisciplinary;Occupational activity of managing finances;Outcome;Positioning Attribute;Preparation;Principal Investigator;programs;Progress Reports;Publications;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Resource Sharing;Resources;Role;Schedule;Science;Secure;Series;Services;success;symposium;Teacher Professional Development;therapeutic development;Training;Translational Research;Travel;Underrepresented Minority;Underrepresented Populations;Universities;Update;web site

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: EUGENE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: 8. Project Narrative Latinx adults are typically underrepresented in study samples, limiting what is known about differences in systemic conditions within Latinx communities that have led to disproportionate disease burden before and throughout the COVID-19 pandemic. The current proposal describes an innovative approach to address the limitations of prior research and inform prevention and control strategies designed for sub-groups within the Latinx community who experience the greatest systemic barriers to SARS-CoV-2 testing and vaccination. Study findings on the most important systemic conditions related to engagement in COVID-19 preventive behaviors and access to preventive services for Latinx sub-groups have potential to inform disease mitigation efforts among Latinxs beyond COVID-19 and, ultimately, promote health equity.

PI_NAMEs: BUDD, ELIZABETH L;DE ANDA, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Address;Adult;Age;barrier to testing;Behavior;burden of illness;Common Data Element;Communities;community partners;Country;COVID-19;COVID-19 pandemic;COVID-19 testing;Data;data harmonization;Death Rate;design;Discrimination;Disease;disorder control;disorder prevention;Economics;Education;Equation;Ethnic Origin;Ethnic Population;experience;food insecurity;Gender;Geography;health care availability;health disparity;health equity promotion;health inequalities;Heterogeneity;Hispanic;Hospitalization;Household;Housing;Immigration;Income;Individual;inequitable distribution;Inequity;Influenza vaccination;innovation;Investigation;Knowledge;knowledge base;Language;Latina;Latino;Latinx;Latinx population;Lead;Literature;Measures;Medicaid;Meta-Analysis;Methods;Mexico;Modeling;mortality;Non-Insulin-Dependent Diabetes Mellitus;Oregon;Outcome;pandemic disease;Participant;Persons;Phase;Population;Prevention;Preventive;Preventive service;public health research;Race;racial discrimination;racial population;racism;RADx Underserved Populations;Reporting;Research;Research Personnel;residence;Sampling;Sampling Studies;SARS-CoV-2 positive;sex;Sexism;Site;social;social health determinants;Standardization;Subgroup;systemic barrier;Techniques;Testing;testing access;theories;United States National Institutes of Health;uptake;Vaccinated;Vaccination;vaccination outcome

PROJECT_TITLE: A Multi-site Investigation of Social Determinants of Health and SARS-CoV-2 Testing and Vaccination Outcomes among Diverse US Latinx Adults


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Social Determinants of Health

PI_NAMEs: CARTER, VIVIAN L (contact)

PROJECT_TERMS: Address;African American;Alabama;Awareness;Biomedical Research;Black Populations;Black race;cancer care;cancer genomics;Collaborations;Communities;community based participatory research;community based research;community engagement;Community Networks;community organizations;community partners;community research;community-centered;County;Data;Data Linkages;Databases;design;Disease;Education;evidence base;Fostering;Generations;Genomics;graduate student;Health Disparities Research;health disparity;Healthcare;innovation;Latinx population;Learning;Link;Marketing;meetings;member;Mentorship;Methods;Modality;Modeling;Obesity;participant retention;Pattern;PhenX Toolkit;Process;programs;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Role;social health determinants;social media;Study Subject;Surveys;synergism;System;theories;Training;undergraduate student;Universities

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Obesity;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: BEDI, DEEPA  (contact)

PROJECT_TERMS: Address;Admixture;Adopted;advanced disease;Adverse effects;African;African American;African American Women;African ancestry;African Women;Age;Alabama;American;anti-cancer research;Asian ancestry;Behavioral;Biological;Biological Markers;Biomedical Research;Black race;Breast Cancer Patient;breast cancer progression;Breast Cancer Risk Factor;Cancer Biology;Cancer Burden;cancer care;cancer survival;Case/Control Studies;cell type;Characteristics;Chronic;Clinic;Clinical;Communities;Complex;Data;data integration;data modalities;Death Rate;differential expression;Disease;Disease Progression;Disparity;Environmental Risk Factor;environmental stressor;Epigenetic Process;Epithelium;ethnic minority;Ethnic Origin;European;evidence base;experience;Genes;Genetic;genome sequencing;Genomics;Goals;health disparity;Health Personnel;Health Services;Health system;High Prevalence;imaging modality;Immune;Immunologics;Immunosuppression;Incidence;Inequity;Inferior;Inflammation;Inflammatory;Infrastructure;innovation;Interdisciplinary Study;Intervention;Link;Malignant Breast Neoplasm;Malignant Neoplasms;marginalization;Medical Electronics;Methylation;Minority Groups;minority patient;Molecular;Morbidity - disease rate;mortality;mortality disparity;multiplexed imaging;Nature;novel;Nutritional;Obesity;obesogenic;Oncology;outcome disparities;Pathology;patient oriented;patient population;Patient Self-Report;Patients;Phenotype;PhenX Toolkit;Play;Population;programs;Protocols documentation;Race;racial difference;racial disparity;racial minority;Records;Risk;Risk Factors;Role;Sampling;Severities;social;social factors;social health determinants;spectrograph;Surveys;systemic inflammatory response;tool;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Biology;tumor heterogeneity;tumor progression;tumor-immune system interactions;Universities;White Women;whole genome;women's outcomes;Work

PROJECT_TITLE: Role of obesity as a causative factor of breast cancer in women of African American ethnicity


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Narrative Based on preliminary studies of S. aureus vaccine failures, we have generated a model of how pre- existing anti-staphylococcal humoral response shapes protective and non-protective immune responses to S. aureus. We will leverage new in vivo model systems to interrogate our hypothesis using protective and non-protective antibodies isolated from children and elderly subjects with invasive S. aureus disease.

PI_NAMEs: CREECH, CLARENCE BUDDY;LIU, GEORGE Y (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Accounting;Active Immunization;Address;Age;alpha Toxin;Animal Model;Antibiotic Resistance;Antibodies;Antibody Response;Antibody-mediated protection;Antigen Targeting;Antigens;Bacterial Infections;Biological Assay;Biological Models;Child;Clinical;Clinical assessments;clinically relevant;cohort;Coupled;cytotoxicity;Development;Disease;Elderly;Environment;experimental study;exposed human population;Exposure to;Generations;Genes;Genus staphylococcus;Goals;Human;Human Characteristics;human pathogen;humanized mouse;Immune;Immune response;Immunity;Impairment;imprint;In Vitro;in vivo;in vivo Model;Infection;Infrastructure;insight;Intervention;Kinetics;Life;Membrane Proteins;Memory;Modeling;mouse model;Mus;novel;novel strategies;older adult;Passive Immunization;Patients;predictive modeling;prevent;Prospective cohort;prototype;rational design;recruit;Reporting;response;Sampling;Sepsis;Series;Serology;Serum;Shapes;Staphylococcal Infections;Staphylococcal Vaccines;Staphylococcus aureus;Staphylococcus aureus infection;success;Surveys;Vaccination;vaccination strategy;vaccine candidate;vaccine development;vaccine efficacy;vaccine evaluation;vaccine failure;vaccine response;Vaccines

PROJECT_TITLE: Interrogating human anti-staphylococcal antibody responses for S. aureus vaccine insights

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: This project provides solid theoretical foundation as well as a set of practical and scalable tools for extending deep learning to EHR data analysis and many other data science tasks. The health prediction system developed under this project will greatly enhance applications of deep learning to public health and subsequently improve patient care.

PI_NAMEs: LIANG, FAMING  (contact);WANG, XIAOFENG

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;Computers;Data;Data Analyses;data imputation;Data Science;deep learning;deep neural network;dimension reduction;Electronic Health Record;flexibility;Foundations;Health;heterogenous data;Image;improved;innovation;Lasso;Laws;Learning;Linear Models;Markov chain Monte Carlo methodology;Medical;Methods;multidimensional data;neural network;Patient Care;Patients;Public Health;Sample Size;Scientist;Solid;Structure;System;Technology;theories;tool;Training;Uncertainty

PROJECT_TITLE: Stochastic Deep Learning for Electronic Health Records: Localizing Learning with Massive and Fragmented Data


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related

PI_NAMEs: ABDALLA, EHSAN  (contact)

PROJECT_TERMS: 19 year old;Address;Adolescent;Adult;Age;aged;Alabama;Apple;Area;Attention;Awareness;Biomedical Research;Black race;Centers for Disease Control and Prevention (U.S.);Charge;Child;Community Pharmacy;Counseling;County;design;Development;Education;Educational Intervention;Educational workshop;effectiveness evaluation;Electronics;Eligibility Determination;Enrollment;Family Planning Programs;feasibility testing;Feedback;Fees;Female;Foundations;Frequencies;Funding;Goals;Health;health communication;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immunization;Improve Access;improved;innovation;Institutional Review Boards;Intervention;Knowledge;Legal patent;Long-Term Effects;male;Medicaid;Medicaid eligibility;medically underserved population;member;Neighborhood Health Center;Nurses;Parents;Participant;Patients;pediatrician;Pharmacy facility;Physicians;Population;prevent;Primary Care Physician;primary care provider;programs;Provider;Public Health;Recommendation;Research;Research Personnel;Resources;Rural;rural setting;Services;Site;South American;Surveys;tool;Uninsured;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;Universities;Vaccination;vaccine acceptance;Vaccines;virtual

PROJECT_TITLE: An Intervention to Increase Knowledge about HPV in Alabama's Black Belt Counties


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Infectious Diseases;Mental Health;Prevention;Sexually Transmitted Infections;Substance Misuse;Violence Research

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Young men’s alcohol-related sexual risk behavior and resistance of condom use continues to pose an important public health concern contributing to both unplanned pregnancies and the spread of sexually transmitted diseases such as HIV. This project will advance our ability to understand the roles of alcohol, sexual aggression history, and emotional processes in these risk behaviors by investigating emotions and emotion regulation as mechanisms underlying alcohol-related sexual risk. An understanding of the specific mechanisms which drive condom use resistance and sexual risk behaviors will contribute evidence for the development of science driven behavior-change prevention programs.

PI_NAMEs: DAVIS, KELLY CUE (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Acute;Address;aged;Aggressive behavior;Alcohol consumption;alcohol effect;alcohol expectancy;Alcoholic Intoxication;Alcohols;Anger;Attitude;Baseline Surveys;Behavior;behavior change;behavioral construct;Clinical;condoms;coping;Data;design;Development;diaries;Distal;drinking;emotion dysregulation;emotion regulation;Emotional;emotional factor;Emotions;Equation;Event;evidence base;experimental study;follow-up;Foundations;Future;Heterosexuals;HIV;Hostility;Individual;innovation;Intervention;intervention program;Intoxication;Investigation;Knowledge;Laboratories;laboratory experiment;Link;male;Measures;Mediating;Mediation;Mediator;men;Methods;Modeling;Monitor;negative emotional state;Participant;Persons;Planning Theory;Play;Prevention program;Process;programs;Public Health;Randomized;Recording of previous events;Reporting;Research;Resistance;response;Risk;Risk Behaviors;Role;Science;Screening procedure;sex;sexual aggression;Sexual Arousal;sexual risk behavior;sexual risk taking;Sexually Transmitted Diseases;Surveys;Time;trait;unintended pregnancy;Unsafe Sex;young man

PROJECT_TITLE: Men's Sexual Risk Behaviors: Alcohol, Sexual Aggression, and Emotional Factors

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Violence Research

ORG_CITY: ORLANDO

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Dating app-facilitated sexual violence (DAFSV) has substantial negative impacts on victims’ health and is especially common among men who have sex with men (MSM), yet there is an absence of research on DAFSV perpetration and its risk and protective factors among MSM – which is needed to inform the development of effective prevention efforts and policy. Dating apps are the first point of contact between many MSM and their romantic and sexual partners, and DAFSV may function as a pre-cursor to in-person sexual violence, suggesting a need to investigate their intersection and co-occurrence with other public health concerns including problematic drinking and sexual minority stress (e.g., discrimination). To understand these associations between DAFSV perpetration and its risk and protective factors, in-person sexual violence perpetration, alcohol use, and sexual minority stress, and to ultimately identify ways to prevent DAFSV and promote safter dating and sexual interactions among MSM, we will sample 1150 MSM for an online survey (Phase 1) and conduct in-depth qualitative interviews with 60 of these MSM who report DAFSV perpetration.

PI_NAMEs: SCHRIMSHAW, ERIC W;WOERNER, JACQUELINE  (contact)

PROJECT_TERMS: Adult;Age;Alcohol consumption;alcohol effect;Alcohols;Anxiety;Back;Buffers;Cross-Sectional Studies;Data;design;Development;Discrimination;drinking;Emotional;experience;Fright;Geography;Goals;Health;help-seeking behavior;Heterosexuals;Image;Individual;Intervention;Interview;intimate partner violence;Lesbian Gay Bisexual;Lesbian Gay Bisexual Transgender;Link;Literature;meetings;men;men who have sex with men;Mental Depression;Methods;minority stressor;Outcome;Pattern;Persons;Phase;Policies;Population;Post-Traumatic Stress Disorders;prevent;Prevention;protective factors;Public Health;Published Comment;recruit;Reporting;Research;Risk;Risk Factors;Role;same-sex partnership;Sampling;Sex Behavior;Sexual Health;sexual identity;sexual minority;sexual minority stress;Sexual Partners;sexual role;sexual violence;stressor;substance use;Surveys;Symptoms;Technology;Testing;theories;timeline;violence perpetration

PROJECT_TITLE: Dating App Facilitated Sexual Violence Perpetration among Men who Have Sex with Men

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Racial and Ethnic Minority Health Research;Women's Health Research

PI_NAMEs: KARANAM, BALASUBRAMANYAM  (contact)

PROJECT_TERMS: 4T1;Address;Affect;African American;African American population;African ancestry;aggressive breast cancer;Androgen Receptor;anti-PD-L1;anti-tumor immune response;Antibodies;anticancer activity;Antitumor Response;Apoptosis;Binding;Biological;Biological Assay;Biological Markers;biomarker development;biomarker selection;Biomedical Research;Biotinylation;Blood;Bortezomib;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;Breast Cancer Treatment;cancer cell;cancer subtypes;Cell Line;Cells;Chemistry;chemotherapeutic agent;chemotherapy;Cisplatin;Clinic;Clinical;cohort;Combination immunotherapy;CRISPR/Cas technology;Data;design;Deubiquitination;Development;Disease;Disparity;disparity reduction;Dose;Drug Kinetics;Drug Targeting;effective therapy;efficacy validation;endoplasmic reticulum stress;ERBB2 gene;Exhibits;Genomics;Goals;Growth;Growth Factor Receptors;health disparity;Histologic;Hormone Receptor;Human;Immune checkpoint inhibitor;Immunotherapy;improved;In Vitro;inhibitor;inhibitor therapy;insight;Knock-out;Label;Lead;Licensing;Lymphoid;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Measures;Medical;Metabolic;misfolded protein;Modeling;Molecular Weight;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;multicatalytic endopeptidase complex;Mus;Myelogenous;Neoplasm Metastasis;Neutropenia;Normal Cell;novel;Nude Mice;Organoids;Outcome;Paclitaxel;particle;Patient Selection;Patients;PD-1 inhibitors;Peptides;Peritoneal;Pharmaceutical Preparations;Pharmacodynamics;Phenotype;Population;Predisposition;Prognosis;programmed cell death ligand 1;Property;Proteasome Inhibition;Proteasome Inhibitor;protein aggregation;Proteins;Race;racial disparity;receptor;receptor expression;Research;Resistance;response;Safety;Sampling;Signal Pathway;Signal Transduction;small molecule;small molecule inhibitor;Solid;Solid Neoplasm;Specimen;standard of care;Streptavidin;Structure;synergism;System;Therapeutic;therapeutic lead compound;three dimensional cell culture;Thrombocytopenia;Tissue Microarray;Tissues;Toxic effect;Treatment Efficacy;treatment response;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor progression;tumor xenograft;Ubiquitin;ubiquitin isopeptidase;Universities;Venous

PROJECT_TITLE: Augmenting Quadruple Negative Breast Cancer Treatment by ADRM1 Inhibitor Up284


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Here we investigate the epigenetic mechanisms that control the transcriptional activation- repression cycle induced by environmental and stress challenges in keratinocytes, a process that is critical for skin and organismal homeostasis. An in-depth understanding of these regulatory mechanisms may provide new targets in the form of transcription and chromatin regulators to better control excessive proinflammatory and repair responses associated with skin disorders.

PI_NAMEs: GEORGOPOULOS, KATIA  (contact);MORGAN, BRUCE A

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Acceleration;Address;Architecture;Basal Cell;biological adaptation to stress;Cells;Chromatin;chromatin remodeling;Chromatin Structure;Chromosomes;Clone Cells;Complex;Deacetylase;Defect;derepression;DNA;Enhancers;Ensure;Environment;Epidermis;epigenetic memory;Epigenetic Process;epigenetic regulation;epithelial stem cell;Evolution;Gene Activation;Gene Expression;gene induction;gene repression;Genes;Genetic Transcription;Genome;Grant;Heritability;Heterogeneity;histone modification;Homeostasis;Human;Immune;In Vitro;in vivo;Inflammatory;Inflammatory Response;insight;keratinocyte;Kinetics;Lead;Maintenance;Mediating;Memory;Modification;Molecular Conformation;Mus;Nuclear;Nucleic Acid Regulatory Sequences;Nucleosomes;physiologic stressor;Physiological;Post-Translational Protein Processing;posttranscriptional;practical application;preservation;Process;promoter;Proteins;recruit;Recurrence;repaired;Repression;Research;Resolution;response;Rest;Role;Signal Transduction;Site;Skin;skin barrier;skin disorder;Specificity;Stratum Basale;Stress;Testing;Tissues;transcription factor;Transcription Factor AP-1;Transcriptional Activation;Transcriptional Regulation;Translating;Work

PROJECT_TITLE: Epigenetic regulation of epidermal proinflammatory responses

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SAMUEL, TEMESGEN  (contact)

PROJECT_TERMS: Acceleration;Achievement;Address;Alabama;Awareness;base;Biomedical Research;Black race;career development;Communities;community engagement;County;Data;Development;Disease;Equipment;Evaluation;experience;Extramural Activities;Faculty;faculty support;Financial Support;Funding;Goals;Grant;Growth;Health;Health Disparities Research;Infrastructure;institutional capacity;interest;Knowledge;knowledgebase;Leadership;marginalization;member;men who have sex with men;Mentors;Mentorship;Minority Groups;minority health;minority health disparity;Minority Health Research;Minority-Serving Institution;Mission;National Institute on Minority Health and Health Disparities;Outcome;Pilot Projects;Principal Investigator;Productivity;Program Evaluation;programs;Research;Research Personnel;Research Project Grants;Resources;Scientist;skills;success;synergism;System;Teacher Professional Development;Technology;Training;Translations;Universities;Workforce Development

PROJECT_TITLE: Investigator Development Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: WHITE, JASON ANTHONY (contact)

PROJECT_TERMS: Address;Bioethics;Bioinformatics;Biological Sciences;biomedical facility;Biomedical Research;Biometry;Capital;Categories;Cell Culture Techniques;Collaborations;Communities;community engagement;computerized tools;Core Facility;Cryopreservation;Data;design;Development;Equipment;Ethics;Extramural Activities;Faculty;faculty support;Flow Cytometry;Funding;Gene Expression;Goals;Grant;Human Resources;Image;Improve Access;Information Technology;Institution;instrumentation;Maintenance;member;Mentors;Methodology;Methods;Minority;minority health;minority investigator;Minority Participation;minority student;Mission;Modernization;molecular modeling;multidisciplinary;Pathologic;Pilot Projects;Productivity;programs;Reporting;Research;Research Activity;research facility;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;responsible research conduct;Secure;senior faculty;Services;Specific qualifier value;STEM field;success;supportive environment;Technology;Training;United States National Institutes of Health;Universities

PROJECT_TITLE: Research Capacity Core


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Networking and Information Technology R&D (NITRD);Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse;Substance Misuse Prevention;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE The proposed study extends a line of research that seeks to reduce alcohol-involved sexual assault on college campuses by developing the first smartphone application to integrate evidence-based alcohol and sexual assault prevention tools, making them accessible 24/7 for students to use in the moments when they are most needed. This study will use multiple rounds of feedback from students, student service providers, campus administrators, and subject matter experts to develop the app and then test its feasibility in a pilot randomized clinical trial. Findings will provide support for a full-scale test of the app’s impact and lay the groundwork to universally deliver real-time prevention tools to reduce alcohol-involved sexual assault on college campuses.

PI_NAMEs: SCAGLIONE, NICHOLE M (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Administrator;Alcohol consumption;alcohol intervention;alcohol involvement;alcohol misuse;alcohol prevention;Alcoholic Intoxication;Alcohols;arm;Behavioral;behavioral outcome;college;college drinking;Complex;Control Groups;Data;design;Development;diaries;drinking;effectiveness/implementation trial;efficacy trial;Enrollment;Ensure;Evaluable Disease;Evaluation;Event;evidence base;feasibility testing;Feedback;Focus Groups;follow-up;Frequencies;Goals;Harm Reduction;Heavy Drinking;Home;implementation study;Individual;Infrastructure;innovation;instrument;Intervention;Life;Link;Location;longitudinal design;meetings;Methodology;Methods;mHealth;mobile application;Outcome;peer;Persons;Pilot Projects;Prevention;Prevention strategy;Procedures;Process;Property;prototype;Psychometrics;Public Health;randomized, clinical trials;Randomized, Controlled Trials;Reporting;Research;response;Risk;Risk Reduction;service providers;sexual assault;Signal Transduction;Site;smartphone application;Social Environment;Structure;student participation;Students;Technology;Testing;therapy development;Time;tool;Trust;Universities;university student;usability

PROJECT_TITLE: Expanding the uSafeUS Mobile App to Reduce Alcohol-Involved Sexual Assault on College Campuses

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: Newark

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Examining the relationship between numeracy (the ability to comprehend numerical information), risk perception of tobacco-related diseases, and tobacco use behaviors has not yet been fully explored, especially how these relationships differ by demographic factors. This project will use nationally representative public data sets that contain tobacco use, risk perception, and numeracy measures to examine these relationships and determine which populations have low numeracy, do not understand the risks involved with tobacco use, and thus cannot make fully informed decisions on using atobacco product. Identification of these subpopulations will allow tailored educational campaign recommendations to be formed (involving numeracy-level appropriate risk communication), which will encourage healthy behaviors and decrease tobacco-related disease outcomes (such as cancer). .

PI_NAMEs: DIAZ, DESTINY  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: 18 year old;Address;Adult;Affect;Area;Authorization documentation;Behavior;cancer prevention;cigarette smoke;Communication;Competence;Comprehension;Data;Data Set;Decision Making;demographic disparity;Demographic Factors;Disease;Disease Outcome;disorder risk;Education;Goals;Health;Health behavior;Health Benefit;Health Campaign;Health Information National Trends Survey;Health Policy;high risk;Individual;International;Legal;Literature;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Marketing;mathematical ability;Measures;Mediating;Modified Risk Tobacco Product;Moods;Perception;Phase;Population;Population Assessment of Tobacco and Health;population health;Postdoctoral Fellow;Predisposition;prevent;preventable death;Prevention;programs;Public Health;Recommendation;Reporting;Research;Research Project Grants;Risk;risk perception;Smoking;smoking cessation;Smoking Status;Subgroup;Surgeon;Techniques;Tobacco;tobacco products;Tobacco use;United States;Work

PROJECT_TITLE: Use and Impact of Quantitative Information in Tobacco Risk Communications


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Soluble adenylyl cyclase (sAC) is essential for sperm function, and both men and male mice with the sAC gene deleted are sterile. Mice given acute acting sAC inhibitors are temporarily infertile with no other observable side effects. Our goal is to develop sAC inhibitors into a safe, `on-demand' male birth control pill whose effects would be temporary and taken only when needed.

PI_NAMEs: BUCK, JOCHEN  (contact);LEVIN, LONNY R

PROGRAM_OFFICER_NAME: LINDSEY, CHRISTOPHER CHARLES

PROJECT_TERMS: absorption;Acrosome Reaction;Acute;Adenylate Cyclase;Anatomy;Animal Model;appropriate dose;Back;Bicarbonates;Binding;Biological Assay;Biological Availability;Cervix Uteri;Characteristics;Chronic;Circulation;clinical development;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;Data;Deposition;design;Development;Dose;drug development;Drug Kinetics;drug standard;efficacy study;Ejaculation;Epididymis;Event;Excretory function;experimental study;Female;female reproductive tract;Fertilization in Vitro;Gene Deletion;Genetic;Glaucoma;Goals;Half-Life;Hour;Human;In Vitro;in vivo;Infertility;inhibitor;Injections;innovation;Investigational Drugs;Investigational New Drug Application;Investments;Kidney Calculi;Kinetics;Knock-out;knockout gene;Knockout Mice;Lead;lead candidate;lead optimization;Legal patent;male;Male Contraceptive Agents;male fertility;Mammalian Oviducts;men;Metabolism;Metaphase;Methods;Molecular;Motility;Mouse Strains;Mus;Mutation;novel;Oocytes;Oral;Oral Contraceptives;Oryctolagus cuniculus;Ovulation;Partner in relationship;Pathology;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiologic Intraocular Pressure;pre-clinical;preclinical development;Preclinical Testing;Predisposition;prevent;Process;Property;Proteins;Research Contracts;residence;Resources;Safety;Series;side effect;small molecule inhibitor;Sperm Capacitation;sperm cell;sperm function;Spermatocytes;Sterility;Swimming;Testing;theories;Therapeutic;Time;Tissues;Topical application;Travel;USAID;Uterus;Vagina;Vaginal Ring;zygote

PROJECT_TITLE: Optimization of lead candidates for an on-demand male contraceptive

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE HIV incidence, although having declined modestly overall in the United States, remains a significant public health problem for young men who have sex with men (YMSM), among whom HIV rates have risen with notable racial, ethnic, and geographic disparities. In response to the continuing HIV epidemic in YMSM and disparities in initiation of and adherence to pre-exposure prophylaxis (PrEP), our study team proposes to expand MyPEEPS Mobile to develop MyPEEPS Mobile Plus, a combination intervention comprised of MyPEEPS Mobile + PrEP E-Peer Navigation to overcome the current challenges of PrEP care among YMSM. If efficacious, MyPEEPS Mobile Plus will support PrEP initiation, adherence, and persistence and decrease HIV risk in diverse YMSM in the United States.

PI_NAMEs: GAROFALO, ROBERT ;SCHNALL, REBECCA  (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, ANGELA R

PROJECT_TERMS: 18 year old;Address;Adherence;Age;AIDS prevention;Awareness;barrier to care;Behavior Therapy;black men who have sex with men;care outcomes;Caring;Cellular Phone;Clinic;Communities;Computers;condoms;cost;Data;Data Collection;digital;Disparity;Education;efficacy evaluation;efficacy testing;Electronics;emotion regulation;Enrollment;Epidemic;epidemiologic data;ethnic disparity;ethnic diversity;ethnic minority;evidence base;experience;Face;Family;Feedback;future implementation;geographic disparity;group intervention;Health Personnel;high risk;HIV;HIV diagnosis;HIV risk;Incidence;Intervention;iterative design;Latino;Logistics;Manuals;Mediation;member;men who have sex with men;Methods;mHealth;mhealth interventions;minority stress;Participant;peer;Persons;Population;pre-exposure prophylaxis;Predisposition;Prevention program;preventive intervention;primary outcome;Principal Investigator;Privatization;Provider;psychoeducation;Public Health;racial disparity;racial diversity;racial minority;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;response;Risk;Risk Behaviors;Rural;Sampling;Sampling Studies;satisfaction;scale up;Sexual Health;sexual health intervention;Sexual Partners;sexual risk reduction;Sexually Transmitted Diseases;side effect;skills;social stigma;Structure;Tablets;Testing;theories;Time;tool;treatment arm;United States;uptake;virtual;young men who have sex with men;Youth

PROJECT_TITLE: MyPEEPS Mobile Plus: A Multi-Level HIV Prevention Intervention for Young MSM


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Despite the successful control of the virus in people with HIV (PWH) with antiviral treatments, elimination or cure is impossible due to the presence of latently infected cells in various anatomical compartments including the brain and CNS. Given the deep breadth of knowledge on viral latency the peripheral reservoir cells (e.g. resting CD4+ T cells), several approaches for treatment exist, including “kick and kill” strategies, whereas, there is limited understanding of the myeloid cell viral reservoirs in the CNS. Using our recently developed novel multicellular human 3D-brain organoids with microglia from brain of HIV infected individuals, we will assess how HIV-1 establishes latency in these cells in CNS, that will help us to further develop therapeutic approaches to either activate and treat or silence the virus.

PI_NAMEs: AYYAVOO, VELPANDI  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: 3-Dimensional;Anatomy;Anti-Retroviral Agents;antiretroviral therapy;Astrocytes;Biological;Biological Models;Biopsy;Blood;Blood - brain barrier anatomy;Blood Vessels;Brain;CD4 Positive T Lymphocytes;Cell Lineage;cell type;Cells;Central Nervous System;Central Nervous System Infections;Data Set;Development;DNA;Epigenetic Process;epigenetic regulation;epigenomics;explainable machine learning;Genetic Transcription;histone modification;HIV;HIV-1;Human;humanized mouse;Immune system;improved;In Vitro;in vivo;Individual;Infection;Infiltration;innovation;Knowledge;large datasets;latent virus activation;Long Terminal Repeats;lymphoid organ;Lymphoid Tissue;Macrophage;Maintenance;Methylation;Microglia;Modality;Modeling;monocyte;mouse model;Mucous Membrane;multimodal data;Myelogenous;Myeloid Cells;Network-based;Neurons;Neuropathogenesis;new therapeutic target;novel;novel strategies;Organoids;overexpression;Pathogenesis;Pathway interactions;Peripheral;Persons;Pharmaceutical Preparations;Physiological;Process;promoter;Proteins;reactivation from latency;reconstitution;Rest;Role;Signal Pathway;single cell ATAC-seq;single-cell RNA sequencing;Structure;System;Systems Biology;Therapeutic;Tissues;transcription factor;Transcriptional Regulation;transcriptomics;transmission process;Variant;Viral;Viral reservoir;Virus;Virus Latency

PROJECT_TITLE: Understanding the mechanisms involved in HIV-1 CNS latency

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Research in hematology has been at the cutting edge of medical advances for decades, providing novel paradigms for the study of human disease. Nevertheless, hematologic diseases remain major public health problems, and the number of physician-scientists dedicated to the study of hematology is declining. This grant is focused on clinician scientists and aims to support a laboratory-based training program to nurture the next generation of hematologists focused on research in molecular hematology.

PI_NAMEs: BERLINER, NANCY  (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: molecular hematology;Training Programs

PROJECT_TITLE: Training Program in Molecular Hematology

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM (JA)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Chronic Obstructive Pulmonary Disease;Complementary and Integrative Health;Lung;Microbiome

ORG_CITY: BIRMINGHAM

ORG_NAME: ALVEOLUS BIO, INC.

PHR: PROJECT NARRATIVE Emerging research strongly suggests that adverse changes in the lung microbiome increase neutrophilic inflam- mation, which is associated with chronic lung diseases such as chronic obstructive pulmonary disease (COPD). The development of microbiome-targeting biotherapeutic drugs holds significant promise to address this problem by reducing pulmonary inflammation. The goal of this proposal is to develop and demonstrate efficacy of a lead therapeutic candidate that is based on extracts of specific Lactobacillus strains for treatment of neutrophilic in- flammation and dysbiosis associated with COPD.

PI_NAMEs: NICOLA, TEODORA  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acetylation;Acute;Address;Adrenal Cortex Hormones;Affect;airway remodeling;alternative treatment;American;Animals;Anti-Inflammatory Agents;Bacteria;Biological Response Modifier Therapy;Biology;bronchial epithelium;Bronchodilator Agents;Cause of Death;Cell Culture Techniques;Cell model;Cells;Cessation of life;chemical stability;Chemicals;chemokine;Chronic;chronic inflammatory lung disease;Chronic lung disease;Chronic Obstructive Pulmonary Disease;clinical efficacy;Collaborations;Combined Modality Therapy;commercialization;comparison control;Complementary therapies;cytokine;Data;Degenerative Disorder;density;Development;Disease;disease model;Disease Progression;dosage;Dose;drug development;Drug Formulations;drug inhalation;Dryness;dysbiosis;efficacy evaluation;efficacy study;efficacy testing;Epithelial Cells;exosome;experience;exposed human population;Extracellular Matrix;Extracellular Matrix Degradation;first-in-human;Formulation;Frequencies;Future;Gelatinase B;Generations;Glycine;Goals;Health Status;Human;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inhalation;Inhalation Device;Interleukin-1 beta;Interleukin-8;Lactic acid;Lactobacillus;Lactobacillus acidophilus;Lactobacillus casei rhamnosus;Lactobacillus plantarum;Lead;lead candidate;Legal patent;Leukocyte Elastase;Licensing;Lipopolysaccharides;Lung;Lung Diseases;lung microbiome;Mammals;men;microbial;microbiome;microbiome alteration;microbiome research;Modality;Modeling;Monitor;mortality risk;mouse model;Mus;neutrophil;Particle Size;Patients;Peptide Hydrolases;Peptides;Peptidoglycan;Persons;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase;Phosphodiesterase Inhibitors;Pneumonia;Powder dose form;pre-clinical;preclinical study;Probiotics;Process;Production;Proline;Property;Proteobacteria;pulmonary function;Pulmonary Inflammation;Quality of life;recruit;Research;Respiratory Disease;Respiratory Stimulants;Safety;safety assessment;safety testing;screening;side effect;Smoking;standard of care;Symptoms;Teichoic Acids;Testing;Therapeutic;therapeutic candidate;TNF gene;tobacco smoke exposure;Toxicology;treatment response;Woman

PROJECT_TITLE: An Inhaled Microbiome-Targeted Biotherapeutic for Treatment of COPD


ORG_NAME: U.S. NATIONAL INST OF ENVIRON HLTH SCIS

PHR: PROJECT NARRATIVE Pregnancy loss impacts millions of women in the United States and around the world. Understanding how serum response factor works with progesterone, the hormone of pregnancy, to facilitate the successful initiation and continuation of pregnancy will reveal key insights on the biological mechanisms of uterine immune homeostasis when pregnancy goes right and the development of a hostile uterine environment when it goes wrong.

PI_NAMEs: MARQUARDT, RYAN  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Ablation;Adult;Affect;Anti-Inflammatory Agents;Apoptosis;ATAC-seq;Biological;Biological Assay;Cell Nucleus;Cell Proliferation;cell type;Cells;Characteristics;Clinical;cofactor;cytokine;Data;Decidual Cell;Decidual Cell Reactions;Decidualization failure;Development;Diagnosis;Differentiation Antigens;early pregnancy;efficacy evaluation;Embryo;Endometrial;Endometrial Stromal Cell;endometriosis;Environment;epigenome;evidence base;experience;Female Genital Diseases;Fertility;Fibroblasts;Fibrosis;Foundations;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic Transcription;Goals;Habitual Abortion;Homeostasis;Hormones;Human;Immune;Immunosuppression;In Vitro;in vivo;Individual;Infertility;Inflammation;Inflammatory;insight;Knockout Mice;Knowledge;Maintenance;Modeling;Molecular;Mus;Nuclear Receptors;Pathway interactions;Placenta;Play;Polycystic Ovary Syndrome;postnatal;Pregnancy;Pregnancy Complications;Pregnancy loss;prepuberty;prevent;Process;Progesterone;progesterone receptor A;Progesterone Receptors;Puberty;Recurrence;recurrence prevention;Regulation;Reproductive Health;Research;Resolution;response;Role;Serum Response Factor;Signal Transduction;single nucleus RNA-sequencing;Spontaneous abortion;Stromal Cells;success;Testing;Therapeutic;Time;Tissues;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;United States;Uterus;Woman;Work

PROJECT_TITLE: The Role of SRF in Uterine Homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-B (MK)]


ORG_CITY: WASHINGTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Obesity hypoventilation syndrome, accumulation of carbon dioxide in the body, is the most severe form of sleep disordered breathing, which does not have effective drug therapy. We have collected preliminary data showing that a melanocortin 4 receptor (MC4R) agonist setmelanotide, which is FDA approved to treat genetic obesity, is a powerful stimulator of breathing, and will perform a randomized controlled trial of this drug in mice with obesity hypoventilation and sleep apnea. We will employ state-of-the-art neuroscience tools to identify specific neurons in the brain in which MC4R agonists work to stimulate breathing, enhance responses to carbon dioxide and treat obesity hypoventilation and sleep apnea.

PI_NAMEs: MENDELOWITZ, DAVID ;POLOTSKY, VSEVOLOD Y (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Acute;Adherence;Affect;Agonist;airway obstruction;Attenuated;awake;Biological Markers;Brain;Brain Stem;breath pacemaker;Breathing;Carbon Dioxide;Cell Nucleus;Chronic;Continuous Positive Airway Pressure;Data;Depressed mood;designer receptors exclusively activated by designer drugs;diet-induced obesity;Dose;Eating;Electrophysiology (science);Energy Metabolism;FDA approved;Fiber;Genetic;Heart failure;Hormones;Human;Hypercapnia;Hypothalamic structure;Hypoventilation;In Vitro;Label;Leptin;Leptin deficiency;Ligands;Link;Melanocortin 4 Receptor;Melanocortin 4 receptor mutation;Messenger RNA;metabolic rate;Metabolism;mortality;Motor;Motor Neurons;Mus;Mutation;Neurons;Neurosciences;neurotransmission;Obese Mice;obese patients;Obesity;obesity genetics;obesity in children;obesity treatment;Obstructive Sleep Apnea;patch clamp;Pathway interactions;Peptides;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Pickwickian Syndrome;posttranscriptional;prevent;Pro-Opiomelanocortin;Pulmonary Hypertension;randomized placebo controlled trial;Randomized, Controlled Trials;Receptor Activation;Resistance;respiratory;respiratory examination;Respiratory Failure;response;Rodent;Role;selective expression;SHU 9119;Sleep;Sleep Apnea Syndromes;Spinal Cord;Synapses;Therapeutic;therapeutic development;tool;Transcription Process;Transfection;ventilation;Work;α-Melanocyte stimulating hormone

PROJECT_TITLE: Melanocortin 4 receptor agonists to treat sleep disordered breathing in obesity

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Post-surgical TNBC recurrence is the major cause of the poor prognosis of TNBC patients. This proposal aims to identify intracellular ferritin as a new TNBC therapeutic target and develop a ferritin-degrading proteolysis targeting chimeras (PROTACs) molecule to leverage the intracellular ubiquitin-proteasome system to degrade ferritin to induce the TNBC cell pyroptosis. The endogenous platelets will be applied to encapsulate developed ferritin degraders for enhanced in vivo pharmacokinetics and anti-TNBC recurrence efficacy, which can serve as monotherapy or synergize with current immunotherapeutics to prevent post-surgical TNBC recurrence.

PI_NAMEs: HU, QUANYIN  (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: 4T1;Abraxane;Address;anti-PD-1;anti-PD1 antibodies;Antibodies;Antineoplastic Agents;Biodistribution;Blood Platelets;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Treatment;cancer immunotherapy;cancer recurrence;cancer site;CASP3 gene;Cell Proliferation;Cells;Cessation of life;chemotherapy;Circulation;Clinic;Clinical;clinical application;Combined Modality Therapy;Data;design;dimer;Dose Limiting;Drug Carriers;Drug Kinetics;Drug resistance;drug resistance development;Drug Targeting;effective therapy;Encapsulated;Engineering;Equilibrium;Ferritin;flexibility;Frequencies;Growth;Home;Human;Immune;Immune checkpoint inhibitor;immunogenic cell death;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;inhibiting antibody;intravenous injection;Ions;Iron;Length;Ligands;liquid chromatography mass spectrometry;Malignant Breast Neoplasm;Malignant neoplasm of lung;Mammary Gland Parenchyma;MDA MB 231;MEKs;Melanoma;mineralization;Modality;mortality;mouse model;mTOR Inhibitor;multicatalytic endopeptidase complex;Mus;Neoadjuvant Therapy;novel;novel therapeutics;Oleic Acids;Operative Surgical Procedures;Paclitaxel;Pathway interactions;patient derived xenograft model;patient prognosis;patient subsets;Patient-derived xenograft models of breast cancer;Performance;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Polyethylene Glycols;prevent;Prognosis;Protac;Relapse;response;Route;Serum;Severity of illness;side effect;single-cell RNA sequencing;Site;small molecule;Somatic Mutation;Structure;success;synergism;System;Techniques;Testing;Therapeutic;therapeutic target;Time;Tissues;Toxic effect;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;Ubiquitin;ubiquitin-protein ligase;wound

PROJECT_TITLE: Engineering ferritin degrader-encapsulated platelets for post-surgical TNBC treatment

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


ADMINISTERING_IC: DK

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Prevention

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

ORG_STATE: TX

PHR: PROJECT NARRATIVE The goal of this research project is to develop a system and method for multiparametric ultrasound (mpUS) imaging of nonalcoholic fatty liver disease (NAFLD) including early pathology progression.

PI_NAMEs: HOYT, KENNETH  (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Address;Affect;Basic Science;Benign;Biological Markers;biophysical model;Blood flow;Calibration;Caring;chronic liver disease;Cicatrix;Cirrhosis;Clinical;clinical implementation;clinical translation;comorbidity;contrast enhanced;cost;cost effective;Coupling;Data;data modeling;Development;Diagnosis;diet and exercise;Discrimination;Disease;disease diagnosis;Disease Progression;drug candidate;Drug Industry;Early Diagnosis;elastography;Fatty acid glycerol esters;Fibrosis;Goals;Hepatocyte;Histologic;Human;Image;imaging biomarker;imaging system;Imaging technology;in vivo;Inflammation;innovation;Life;Life Style Modification;Link;Lipids;Liver;liver biopsy;Liver diseases;Liver Fibrosis;liver imaging;liver inflammation;liver transplantation;Lobular;Measurement;Measures;Medical;Methods;Modeling;Monitor;non-alcoholic fatty liver disease;Non-Invasive Detection;nonalcoholic steatohepatitis;Obesity Epidemic;Pathology;Patients;Pattern;Performance;Perfusion;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Prevalence;Primary carcinoma of the liver cells;rapid growth;Rattus;Research;Research Project Grants;Research Proposals;Risk;Sampling Errors;Severities;simple steatosis;Staging;Surrogate Markers;Symptoms;System;Technology;Testing;Tissues;Ultrasonography;ultrasound;United States;Validation;virtual;Viscosity

PROJECT_TITLE: Multiparametric ultrasound imaging for early detection of nonalcoholic fatty liver disease

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: Project Narrative: Native American groups are among the most under-represented groups across STEM disciplines, including Brain Sciences. This disparity has arisen from a number of historical and institutional challenges. To meet this challenge, we propose the creation of a research education program to support post-baccaulareate students as they transition into graduate school in developing scientific literacy, research, and laboratory skills focused on neuroscience.

PI_NAMEs: RODGERS, KATHLEEN E. (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Academic support;Accountability;Address;Aging;animation;Awareness;Bachelor's Degree;Biomedical Research;Brain;brain health;Caring;cohort;Communities;community involvement;cultural competence;Cultural Diversity;Degree Completion;design;Development;Diagnosis;diagnostic criteria;Disease;Disparity;Distress;Doctor of Philosophy;Education;education pathway;education research;educational atmosphere;Educational Status;Educational workshop;Elements;Engineering;Ethnic Origin;Evaluation;experience;Face;financial literacy;Financial Support;Fortification;Funding;General Population;Goals;Graduate Degree;graduate school;graduate school preparation;graduate student;Grant;Health;health disparity;Health Professional;higher education;Individual;Institution;interest;Internships;Journals;Knowledge;Laboratories;Learning;Life;Link;literacy;meetings;Mentors;Minority;Modeling;Native American community;Native American population;Native Americans;Nervous System;Nervous System Disorder;Neurologic;Neurosciences;Neurosciences Research;Patients;Pattern;Persons;Philosophy;Physicians;Population;Postbaccalaureate;Postdoctoral Fellow;Prevalence;Principal Investigator;programs;Psyche structure;psychoeducation;recruit;Research;research and development;Research Personnel;Research Training;Schools;Science;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;scientific literacy;Scientist;Series;Site;skill acquisition;skills;Social support;sound;STEM career;STEM field;Stroke;student retention;Students;summer research;Surveys;System;Technology;Time;Training;Training Programs;tribal college;Trust;undergraduate student;Underrepresented Populations;United States;United States National Institutes of Health;Universities;virtual;Vocational Guidance

PROJECT_TITLE: Neuroscience Diversity to Elevate Education and Research Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-L (25)]


ORG_CITY: Columbus

ORG_DEPT: SURGERY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Optimal outcomes after surgery may be impaired due to immune mechanisms which cause tissue injury or interfere with healing. The goal of this program is to inspire and train the next generation of surgeon-scientists who will lead immunology research focused on solutions for clinical problems relevant to tissue injury, repair, regeneration and replacement. Discoveries by these surgeon-scientists are anticipated to lead to new tools for diagnosis or prognosis of immune-mediated diseases and also to new immunotherapies which improve surgical outcomes.

PI_NAMEs: BUMGARDNER, GINNY L (contact);WISLER, JON R

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Immunology;Operative Surgical Procedures;Research Training

PROJECT_TITLE: Advanced research training in immunology for surgery trainees (ARTIST)

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: GABORONE

ORG_COUNTRY: BOTSWANA

ORG_FIPS: BC

ORG_NAME: UNIVERSITY OF BOTSWANA

PHR: Lack of effective HIV pre-exposure prophylaxis (PrEP) programs is a significant contributor to ongoing spread of HIV in sub-Saharan Africa (SSA). Our proposed study, to be conducted in Botswana, will leverage a successful national ART program and infrastructure to first test a set of strategies for the general population (18-49 years old) to increase PrEP uptake using information and communications technology to expand reach, reduce barriers due to mobility and competing needs for work. Based on lessons learnt from the preliminary study, we will then assess if PrEP uptake and persistence will be better with the new strategies as compared to the way PrEP is currently being offered in Botswana.

PI_NAMEs: BOGART, LAURA M;HIRSCHHORN, LISA ;MOSEPELE, MOSEPELE  (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Adherence;Adoption;Adult;Africa South of the Sahara;arm;Botswana;Client;Clinic;cluster randomized design;Cluster randomized trial;Collaborations;Communication;Communities;Consolidated Framework for Implementation Research;contextual factors;Country;COVID-19;digital;Education;Effectiveness;effectiveness outcome;Eligibility Determination;Epidemic;Evaluation;evidence base;Female Adolescents;follow-up;General Population;Health care facility;health management;Health Personnel;Health Policy;Health system;Healthcare Systems;Heterosexuals;HIV;HIV Infections;Human immunodeficiency virus test;Hybrids;implementation measures;implementation outcomes;implementation strategy;improved;Incidence;Individual;Infrastructure;Inservice Training;Interview;Knowledge;Maps;member;Methods;mobile computing;Mother-to-child HIV transmission;Outcome;peri-urban;Persons;pilot test;Policy Maker;Population;pre-exposure prophylaxis;preference;Privatization;programs;Provider;public-private partnership;randomized, clinical trials;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Recommendation;Reporting;Research;response;Risk;Rural;Schedule;secondary outcome;self testing;service delivery;Service delivery model;service providers;Services;Site;social media;social stigma;Social support;success;Target Populations;Technology;Testing;transmission process;uptake;Visit;Work;World Health Organization;young woman

PROJECT_TITLE: Evaluation of PrEP implementation strategies for the general population in Botswana

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-A (03)]


NIH_SPENDING_CATS: Cancer

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: PROJECT NARRATIVE This T32 renewal application seeks continued funding to provide postdoctoral training in Behavioral Oncology research. Since 2003, the program has successfully attracted and recruited from a talented and diverse pool of applicants and has provided postdoctoral trainees with the skills, experiences, and high-quality mentoring needed to become successful investigators. Building on our prior success, this renewal will foster skills to address established and emerging areas of need in Behavioral Oncology, approach research from a lens of health equity, and leverage transdisciplinary science to generate sustainable impact on patients and communities.

PI_NAMEs: SIMMONS, VANI N;VADAPARAMPIL, SUSAN T (contact)

PROJECT_TITLE: Behavioral Oncology Education & Career Development

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE: This program trains the next generation of immunologists who will lead the innovative research, teaching, and biomedical entrepreneurship that is needed to advance basic science and develop new translational approaches for the prevention and treatment of autoimmune diseases and cancer, the improvement of organ transplantation, and the design of new and more effective vaccines. The funding will contribute to public health by supporting the training of highly skilled individuals who will join the national biomedical research workforce.

PI_NAMEs: SAVAGE, PETER AIDAN (contact)

PROJECT_TERMS: Immunology;Training Programs

PROJECT_TITLE: Interdisciplinary Training Program in Immunology


ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: This is an institutional training program to train physician and non-physician (PhD) scientists in a collaborative manner to become research leaders in two closely related areas: abnormal formation of blood clots (thrombosis) and the body’s response to injury or infection (inflammation). Thrombosis and inflammation are present in a broad range of severe human diseases in need of greater research, ultimately leading to advances in health.

PI_NAMEs: CRUZ, MIGUEL ANGEL;RUMBAUT, ROLANDO E (contact)

PROJECT_TITLE: Collaborative Research Training in Thrombosis and Inflammation


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE Myopia, or nearsightedness, is a significant public health concern because, in addition to the high costs and socio-economic burden, myopia can lead to permanent vision loss and ocular abnormalities causing blindness. Moreover, recent evidence suggests that the prevalence of myopia and, consequently, its impact are increasing rapidly. Hence, we aim to identify novel targets for urgently needed treatment strategies to prevent and reduce the degree of myopia.

PI_NAMEs: OSTRIN, LISA A (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Address;Adolescent;Affect;Anisometropia;Area;Biomechanics;Biometry;Blindness;cell type;Cells;Cellular biology;Child;clinical practice;collagenase;comparison control;cost;Data;Data Set;Development;differential expression;Discipline;Disease;Down-Regulation;Economic Burden;effective therapy;Epidemic;Etiology;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Eye;Fibroblasts;Foundations;Funding;Future;Gene Expression;Genes;Genomics;Goals;Growth;Human;human model;In Situ Hybridization;Incidence;Intervention;Investigation;Knowledge;lens induction;Macaca mulatta;Mass Spectrum Analysis;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Measurement;Mediating;Mediator;Methods;Modeling;Molecular;Molecular Biology;Myopia;Nature;nonhuman primate;novel;novel therapeutics;Optics;Pathology;Pathway interactions;Peripheral;Phenotype;Population;Population Dynamics;Prevalence;prevent;Primates;programs;Proliferating;protein expression;Proteins;Proteomics;Public Health;Quality of life;Research;Resources;response;Risk;Risk Reduction;Role;Sclera;Shotguns;single cell sequencing;single-cell RNA sequencing;socioeconomics;Strategic Planning;Structure;Techniques;Testing;Tissue Inhibitor of Metalloproteinases;Tissues;Transcript;transcriptomics;Transforming Growth Factor beta;Translating;treatment strategy;Validation;Visual;Visual impairment;Work

PROJECT_TITLE: Optically Induced Anisometropias


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: PROJECT NARRATIVE Adolescents with Autism Spectrum Disorder experience depression at rates nearly twice that of their neurotypical peers, yet risk factors for depression in autism are not well understood and interventions are limited. Longitudinal, multimethod assessment of social and nonsocial reward responsivity and associations with depression symptoms in autism will advance mechanistic models, informing intervention development. This project will be the first to examine how relationships between reward responsivity and depression symptoms change over time in adolescents with autism, clarifying risk factors and potential intervention targets for this vulnerable population.

PI_NAMEs: SCHWARTZMAN, JESSICA M (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 17 year old;Adolescence;Adolescent;adolescent with autism spectrum disorder;Adult;autism spectrum disorder;Behavioral;Biological Markers;career;career development;child depression;Clinical;clinical translation;Communication difficulty;Complex;depressive symptoms;Development;Development Plans;Developmental Course;Diagnostic;Early Diagnosis;Early Intervention;Electroencephalography;emotional experience;Employment;Event-Related Potentials;experience;Face;Family member;follow-up;Future;Goals;High Prevalence;high risk;Impairment;Intervention;Interview;Investigation;Knowledge;Literature;longitudinal analysis;longitudinal design;Maintenance;Measurement;Measures;Mental Depression;Mental disorders;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;method development;Methodology;Methods;Modeling;Mood Disorders;mortality risk;National Institute of Mental Health;neural;Neurobiology;neurophysiology;novel;Outcome;Pathway interactions;peer;physical conditioning;Population;Positive Valence;premature;Prevalence;prospective;Provider;Psychophysiology;Quality of life;recruit;Research;Research Domain Criteria;response;Rewards;Risk;Risk Factors;Sampling;Schedule;Schizophrenia;Schools;screening;Severities;social;social communication;Social Interaction;Social Processes;Strategic Planning;suicidal morbidity;symptomatology;Symptoms;Techniques;Testing;therapy development;Time;Training;Translating;Translational Research;Vulnerable Populations;Work

PROJECT_TITLE: Reward responsivity and depression in autism spectrum disorder: A multimethod approach


ORG_CITY: HANOVER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: The goal of this proposal is to continue and improve a program to train the next generation of immunologists and provide them with the tools needed to forge successful careers in research. We recruit the most talented and motivated predoctoral students and our outstanding faculty trainers provide exceptional mentorship and training in how to conduct research in immunology, in addition to preparing them for careers in research and research-related fields. The immune response cuts across all types of disease in the human population, and we are at the beginning of our ability to develop therapies to harness the immune responses for novel therapies, so progress in this field is essential.

PI_NAMEs: JAKUBZICK, CLAUDIA V (contact)

PROJECT_TITLE: Immunobiology of Myeloid and Lymphoid Cells


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Sexually Transmitted Infections

ORG_CITY: SAN CLEMENTE

ORG_NAME: CENTER FOR INNOVATIVE PUBLIC HEALTH RESEARCH

PHR: If efficacious, ITG has the potential to help curb the alarming increase in HIV incidence among Ugandan young people as they age through young adulthood. Given its scalability and low cost, this powerful intervention could be quickly added to the currently small arsenal of HIV prevention programs for young adults in Uganda, if warranted. We are partnering with the Ministry of Health to guide us on sustainability should the findings of this R01 warrant.

PI_NAMEs: YBARRA, MICHELE L. (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: acceptability and feasibility;adolescent sexual health;Adult;Affect;Africa South of the Sahara;African;Age;Age Years;AIDS prevention;arm;Behavior;behavior change;Behavioral;Biometry;Botswana;Cellular Phone;Clinic;cohort;comparison control;Complex;condoms;cost;Country;Data;deafening;design;Development;Education;efficacy trial;Eligibility Determination;emerging adult;emerging adulthood;Face;Feedback;Future;Goals;Health;Healthcare;Heterosexuals;HIV;HIV risk;HIV Seropositivity;Human immunodeficiency virus test;Incidence;Income;innovation;Intervention;intervention participants;Knowledge;Language;Measures;men;multidisciplinary;multiphase optimization strategy;Outcome;Outcome Measure;Ownership;Participant;Persons;pilot test;Population;population based;pre-exposure prophylaxis;Prevalence;prevent;Prevention;Prevention program;Preventive;Procedures;programs;Public Health;Randomized;Recommendation;Research;Resources;retention rate;Risk;Risk Reduction;rural setting;Safe Sex;Sample Size;secondary outcome;self testing;sex;Subgroup;Technology;Testing;Text Messaging;Time;Translating;transmission process;Uganda;United States;uptake;urban area;Woman;Work;young adult;young man;young woman;Youth

PROJECT_TITLE: In This toGether: Testing a population-based text messaging-based HIV prevention program for young adults across Uganda

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ED_INST_TYPE: HOSPITALS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: NARRATIVE: OVERALL This Program of research focuses on delayed treatment sequelae of oropharyngeal cancer (OPC) which has been rising at epidemic pace for several decades. Although contemporary treatment strategies are highly effective at curing OPC, many survivors ultimately spend cancer-free years with disabling toxicities that threaten critical functions such as speaking and eating. The investigators will integrate three Projects focused on highly impactful delayed side effects including jawbone death (osteoradionecrosis), nerve loss (lower cranial neuropathy), and swallowing difficulty (dysphagia) using common infrastructure and synergistic methods of research to understand the time course, mechanisms, non-invasive testing, and treatment options to improve lifelong health and quality of life of OPC survivors.

PI_NAMEs: FULLER, CLIFTON DAVID;HUTCHESON, KATHERINE ARNOLD (contact);LAI, STEPHEN Y

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Adult;Adverse event;Aftercare;Age;Cancer Control;Cancer Patient;Cancer Survivor;Cancer Survivorship;cancer survivorship care;cancer therapy;Cessation of life;Cetuximab;Chronic disability;Cisplatin;clinic ready;Clinical;clinical care;Clinical Markers;cohort;Cohort Studies;Collection;Complex;Conformal Radiotherapy;cost;Cranial nerve diseases;Data Collection;data integration;Data Set;data streams;Deglutition;Deglutition Disorders;Development;Diagnosis;Diagnostic;Disabling;Disease;disorder control;Dose;Early Diagnosis;Eating;Enrollment;Epidemic;evidence base;Failure;follow-up;Functional Imaging;functional status;Head and Neck Cancer;Health;Healthcare Systems;HPV oropharyngeal cancer;Human Papillomavirus;Image;imaging study;improved;Incidence;Individual;Inferior;Infrastructure;Injury;Institution;Intensity-Modulated Radiotherapy;Investigation;Link;Long Term Survivorship;Long-Term Survivors;Magnetic Resonance Imaging;Malignant Neoplasms;malignant oropharynx neoplasm;Managed Care;Mandible;Measures;Meta-Analysis;Modernization;Morbidity - disease rate;Nerve;Normal tissue morphology;novel;novel therapeutics;Oncogenic;Operative Surgical Procedures;Oral;Oropharyngeal;Osteoradionecrosis;Outcome;Patient Outcomes Assessments;Patients;Performance Status;personalized care;personalized management;Persons;phase III trial;Phenotype;Population;Precision Health;Probability;Program Research Project Grants;programs;prospective;Protons;Publishing;Quality of life;Questionnaires;Radiation;Radiation therapy;Radiation Therapy Oncology Group;randomized trial;recruit;Registries;Regrets;Reporting;Research;Research Methodology;Research Personnel;Resource Allocation;Resources;Risk;Robotics;side effect;Staging;Stimulus;Survivors;survivorship;Symptoms;Systemic Therapy;Techniques;Testing;Therapeutic;Time;Tobacco;Toxic effect;treatment strategy;Unemployment;United States

PROJECT_TITLE: OPC SURVIVOR: Optimizing OroPharyngeal Cancer SURVIVORship

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-T (M1)]


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Rare Diseases

PHR: NARRATIVE: CORE A (ADMIN) The purpose of the Administrative Core (Core A) is to provide centralized administrative management, communications hub between Program components, financial oversight and budget administration, clerical and materials management, and compliance with NIH reporting and study conduct for all Projects and Cores. This Core will strive to promote the highest level of integration between the Program components and ensure seamless interactions by facilitating internal and external communication and collaboration between the Investigators and Scientific Advisory Board.

PI_NAMEs: HUTCHESON, KATHERINE ARNOLD (contact)

PROJECT_TERMS: Acceleration;Accountability;Accounting;Advisory Committees;Affect;Algorithms;analytical method;Archives;Budgets;Cancer Research Project;Cancer Survivorship;Collaborations;Communication;Consultations;data sharing;design;Development;digital;Documentation;Ensure;Equipment and Supplies;Evaluation;Expenditure;experience;Feedback;Fostering;Funding Agency;Human Resources;human subject;Individual;Life Cycle Stages;malignant oropharynx neoplasm;meetings;Methodology;Monitor;Office of Administrative Management;Online Systems;operation;Outcome;patient engagement;Patients;Performance;Policies;Principal Investigator;Process;programs;Progress Reports;Protocols documentation;Publications;PubMed;Recommendation;recruit;Reporting;Research;Research Personnel;Resolution;Resource Allocation;Resources;Role;Services;Site;Structure;synergism;Time;United States National Institutes of Health;verbal;Work;Writing

PROJECT_TITLE: Core A: Administrative


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Orphan Drug;Patient Safety;Prevention;Radiation Oncology;Rare Diseases;Rehabilitation

PHR: NARRATIVE: PROJECT 1 (OPC-ORN) Osteoradionecrosis (ORN) is a highly morbid, delayed bone-related complication from radiation therapy with substantial impacts on healthcare costs, function, and quality of life. Our work explores the potential to characterize subclinical mandibular injury that is prevalent before symptomatic manifestation of observable ORN. Validation of risk stratification by dosimetric, imaging, and clinical criteria would enhance our efforts to monitor, mitigate, and treat this devastating delayed sequela of curative treatment.

PI_NAMEs: LAI, STEPHEN Y (contact)

PROJECT_TERMS: Abate;Acute;Adjuvant;Biological Markers;Blood Vessels;bone;Cancer Patient;cancer radiation therapy;Cancer Survivor;Cancer Survivorship;candidate marker;Chemoprevention;Chronic;Cilostazol;Classification;Clinical;Clinical Markers;Clinical Trials;clinically relevant;cohort;comparative;Complication;contrast enhanced;cost;curative treatments;Data;Databases;Deglutition Disorders;Dental;Dental Care;Development;Diagnosis;diagnostic biomarker;Disease;Dose;drug candidate;Early Diagnosis;early phase trial;Epidemic;Event;Excision;Exhibits;experience;Fibrosis;Fistula;Goals;Health;Health Care Costs;Healthcare;HPV oropharyngeal cancer;HPV positive;Iatrogenesis;Image;image guided;imaging biomarker;improved;in vivo;Incidence;indexing;innovation;Jaw Fractures;Kinetics;Knowledge;Magnetic Resonance Imaging;Malignant Neoplasms;malignant oropharynx neoplasm;Mandible;Mandibular Injuries;Measures;Modeling;Monitor;Natural History;Neck;neoplasm registry;Normal tissue morphology;novel;off-label drug;Operative Surgical Procedures;Oral;Oral Surgical Procedures;Organ Preservation;Osteoradionecrosis;Outcome;Pain;patient oriented;Patients;Pentoxifylline;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase;phenotypic biomarker;Photons;Population;potential biomarker;prevent;progression marker;prophylactic;prospective;Prospective cohort;proton therapy;Protons;Public Health;Quality of life;Radiation;Radiation Injuries;Radiation therapy;reconstruction;Reporting;response;revascularization;Risk;Risk Reduction;risk stratification;Severities;standard of care;Statistical Models;Surrogate Endpoint;Surveys;survivorship;Symptom Burden;Symptoms;Syndrome;Therapeutic;Therapeutic Intervention;Time;tissue injury;tool;Toxic effect;Trismus;United States National Institutes of Health;Validation;Vascularization;Work;Xerostomia

PROJECT_TITLE: Project 1: OPC-ORN


NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Prevention;Radiation Oncology;Rare Diseases;Rehabilitation

PHR: NARRATIVE: PROJECT 2 (OPC-NERVE) The incidence of highly curable oropharyngeal cancers is rapidly rising and there are more long-term survivors than ever. Radiation treatment is very commonly given at doses sufficient to cause crippling late cranial neuropathy (loss of nerve function controlling tongue and throat) that can progress to the point that it results in a loss of speech, lifelong feeding tube dependence or death from aspiration pneumonia years after cancer is cured. This application seeks to understand how abnormal nerve function in the tongue may be present and measured long before it is evident in clinic, and whether it is feasibility to offer earlier therapy to help preserve function before irreversible damage is done.

PROJECT_TERMS: Address;Age;arm;aspirate;Aspiration Pneumonia;Atrophic;Behavior Therapy;Behavioral;biomarker validation;Breathing;cancer radiation therapy;Cancer Survivor;Cancer Survivorship;Cessation of life;Chronic;Clinic;clinic ready;Clinical;clinical candidate;Clinical Markers;cohort;cost;Cranial nerve diseases;daily functioning;Data;Deglutition;density;Dependence;Detection;Diagnosis;disability;Dose;Early Diagnosis;Early Intervention;Early treatment;Eating;Electromyography;Electronics;Enteral Feeding;Equipment and supply inventories;evidence base;Exercise;Food;Functional disorder;functional improvement;functional loss;genioglossus muscle;Goals;Head and neck structure;Health;improved;Incidence;Infrastructure;Injury;insight;Life;lifetime risk;Liquid substance;Long-Term Survivors;Lung;Malignant Neoplasms;malignant oropharynx neoplasm;Manipulative Therapies;Measurement;Measures;mobile application;Modernization;Monitor;Morphology;Muscle;Muscular Atrophy;Needles;Nerve;nerve injury;Neuropathy;neurophysiology;Newly Diagnosed;non-invasive system;novel;novel therapeutics;Oropharyngeal;Patient Outcomes Assessments;patient subsets;Patients;pharmacologic;Pharyngeal structure;Phase I/II Trial;Pneumonia;Population;Positioning Attribute;Prednisone;preservation;Prevalence;Procedures;Program Research Project Grants;Progressive Bulbar Palsy;Publications;Publishing;Quality of life;Radiation therapy;Recommendation;Recovery of Function;Refractory;remote monitoring;Reporting;Research Personnel;Safety;Signal Transduction;Speech;Speech Acoustics;Steroid therapy;Supportive care;Surface;Survivors;Symptom Burden;Symptoms;synergism;System;Testing;Therapeutic;Time;Tongue;Tracheostomy procedure;Tube;Work

PROJECT_TITLE: Project 2: OPC-NERVE


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Nutrition;Orphan Drug;Prevention;Radiation Oncology;Rare Diseases

PHR: NARRATIVE: PROJECT 3 (OPC-RAD) Currently the most effective treatment for locally advanced oropharyngeal head and neck cancer is photon (X- ray)–based radiotherapy (IMRT), given with or without chemotherapy; however, this therapy can cause delayed, progressive, irreversible late-radiation-associated dysphagia (L-RAD) that can worsen quality of life and contribute to mortality. Proton-based radiotherapy (IMPT) is being evaluated as a promising, less toxic alternative to IMRT in a randomized trial; however, whether IMPT (vs. IMRT) can prevent L-RAD, and whether pentoxifylline+tocopherol (PENTOCO) can prevent and mitigate L-RAD, are unknown at this time. We propose here to (1) model the risk of developing L-RAD after IMPT vs. IMRT and (2) test whether PENTOCO will prevent and mitigate L-RAD in patients with head and neck cancer.

PI_NAMEs: FRANK, STEVEN JAY (contact)

PROJECT_TERMS: Aftercare;alpha Tocopherol;antifibrotic treatment;aspirate;Barium swallow;Biological;biophysical model;Blood;Blood specimen;Body Weight decreased;Cancer Center;Cancer Survivorship;Cessation of life;chemoradiation;chemotherapy;Chronic;Clinical Trials;cohort;Cutaneous;cytokine;Data;Data Collection;Deglutition;Deglutition Disorders;Dependence;Dose;dosimetry;Dysgeusia;Eating;effective therapy;Enrollment;Ensure;Enteral Feeding;experience;Fibrosis;financial toxicity;Functional disorder;Future;Gastrostomy;Goals;Head and Neck Cancer;Healthcare Systems;Hospitalization;human papilloma virus oropharyngeal squamous cell carcinoma;Human Papillomavirus;Image;Impairment;improved;Incidence;individual patient;Infrastructure;Institution;Intake;Intensity modulated proton therapy;Intensity-Modulated Radiotherapy;irradiation;Linear Energy Transfer;Long-Term Survivors;Lymphedema;Magnetic Resonance Imaging;malignant oropharynx neoplasm;Mastication;Measurement;Measures;Mediating;Modeling;Modernization;mortality;Neuropathy;Normal tissue morphology;novel strategies;operation;Oral;Organ;Oropharyngeal;Oropharyngeal Squamous Cell Carcinoma;Osteoradionecrosis;Outcome;painful swallowing;Participant;participant enrollment;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pentoxifylline;peripheral blood;Pharmaceutical Preparations;Phase;phase III trial;Phenotype;Photons;physical property;Pneumonia;prevent;prospective;Protons;Qualifying;Quality of life;Radiation;Radiation Fibrosis;Radiation induced damage;Radiation therapy;Randomized;randomized trial;Resources;Risk;Risk Assessment;risk mitigation;Risk Reduction;Roentgen Rays;Running;Salivary;secondary analysis;Severities;side effect;Site;soft tissue;Solid;standard of care;subcutaneous;survival outcome;Survivors;Taste Perception;Testing;Therapeutic;Time;Tissues;Tocopherols;tool;Toxic effect;Transforming Growth Factor beta;treatment planning;trial comparing;Trismus;Tube;tumor;Universities;Vitamin E;Xerostomia

PROJECT_TITLE: Project 3: OPC-RAD


NIH_SPENDING_CATS: Bioengineering;Cancer;Data Science;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases;Rehabilitation

PHR: NARRATIVE: CORE B (CLINICAL INFORMATICS & ANALYTICS) The Clinical Informatics & Analytics Core (Core B) will provide a robust informatics infrastructure and coordinated support for study design, data sharing, and data analysis across all projects and cores. This shared resource will provide support for quality control, integration and sharing of data, planning and sample size determination, biostatistical collaboration on clinical trials, and visualization of data for publications resulting from this P01.

PI_NAMEs: MORENO, AMY CATHERINE (contact)

PROJECT_TERMS: Adverse effects;analytical method;Architecture;automated segmentation;Bayesian Method;Biological Markers;biomedical informatics;Biometry;Blood;Cancer Survivor;Cancer Survivorship;central database;clinic ready;Clinical;Clinical Data;Clinical Informatics;Clinical Investigator;clinical trial protocol;Clinical Trials;Clinical Trials Design;clinically relevant;Cluster Analysis;cohort;Collaborations;Collection;Complex;Computer Models;Computer software;Data;Data Analyses;data cleaning;Data Collection;data communication;data dashboard;Data Element;data exploration;data infrastructure;data integration;data management;data pipeline;data quality;Data Set;data sharing;Data Storage and Retrieval;data visualization;Database Management Systems;Databases;design;digital;Electromyography;electronic data;Ensure;Evaluation;Event;experimental analysis;Fostering;Friends;functional outcomes;Generations;Goals;Grant;Health;Human Resources;Image;improved;Informatics;informatics infrastructure;information display;information organization;Infrastructure;innovation;Logistic Regressions;Machine Learning;malignant oropharynx neoplasm;Medical;Metadata;Methods;Modeling;Modernization;novel;Online Systems;Ontology;Operative Surgical Procedures;Oropharyngeal;Outcome;Parents;Patient Outcomes Assessments;Patients;Phenotype;Policies;Postdoctoral Fellow;predictive modeling;preservation;Principal Investigator;Procedures;programs;prospective;Protocols documentation;public repository;Publications;Quality Control;Quality of life;random forest;Regression Analysis;Reporting;Reproducibility;Research;Research Design;Research Personnel;Resource Sharing;Risk;Running;Sample Size;Semantics;Source;Standardization;statistical learning;Statistical Methods;Statistical Models;Survival Analysis;Symptoms;System;Testing;Training;Treatment-Related Cancer;Treatment-related toxicity;United States National Institutes of Health;University of Texas M D Anderson Cancer Center;Validation;Visualization software;Work

PROJECT_TITLE: Core B: Clinical Informatics & Analytics