ORG_CITY: NEW YORK

ORG_DEPT: DERMATOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: NARRATIVE: Gastrointestinal (GI) functions affect overall health and wellbeing and GI motility disorders are common patient complaints and significantly impacts quality of life and productivity with unmet medical need. The function of the enteric nervous system (ENS), the “second brain” in the gut, is essential to GI homeostasis and ENS defects cause GI dysmotility. The current proposal aims to understand the sensory biology in the ENS using unique neurogenetic technologies and identify specific intrinsic primary sensory neurons (IPANs) as new therapeutic target for the treatment of motility-related GI disorders.

PI_NAMEs: HU, HONGZHEN  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Abdomen;Ablation;Address;Affect;Afferent Neurons;Animals;Biological Assay;Biology;Brain;Calcitonin Gene-Related Peptide;Cell Physiology;Cells;Chemicals;cholinergic;Colon;Communication;Complex;Cues;Defect;detection platform;Development;Enteral;Enteric Nervous System;Enteroendocrine Cell;Environment;gain of function;gastrointestinal;Gastrointestinal Diseases;gastrointestinal function;Gastrointestinal Motility;Gastrointestinal tract structure;Gastrointestinal Transit;Genetic;genetic analysis;genetic approach;genetic manipulation;Goals;gut microbiome;gut microbiota;gut-brain axis;Health;Image;Immune;Immunity;in vivo;insight;intestinal barrier;intestinal homeostasis;Intestines;loss of function;Mechanical Stimulation;Mechanics;Mediating;Medical;microbiota metabolites;Modeling;Molecular;Motility;motility disorder;motor behavior;Movement;Mucous Membrane;Mus;Muscle;Nerve;Nerve Endings;Nervous System;Nervous System Disorder;neural;neural circuit;neurogenetics;Neuroglia;Neuromodulator;Neurons;Neuropeptides;new therapeutic target;novel strategies;optogenetics;Organ;Patients;Pattern;Periodicity;Personal Satisfaction;Pharmaceutical Preparations;Physiological;Pilot Projects;Play;Preparation;Productivity;Quality of life;Resources;response;Role;sensor;Sensory;Signal Transduction;Stimulus;Technology;Testing;tool;Translating;treatment strategy;Vertebrates

PROJECT_TITLE: Genetic Analysis of Intrinsic Sensory Neuron Function in the Enteric Neural Circuits

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: KANSAS CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NUTRITION

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE  Impaired brain energy metabolism is an increasingly recognized and targeted component of Alzheimer’s disease (AD), yet methods to assess energy manipulation in the brain are limited. This project will develop techniques to measure brain energy metabolism using 3T 1H/31P magnetic resonance spectroscopy (MRS) and use these new measures to investigate the ketogenic diet's (KD) ability to manipulate brain energy metabolism in aging and AD. The potential impact of this study is significant as our measurement techniques with 3T MRS can be shared across the NIA’s network of Alzheimer’s Disease Research Centers (ADRC), finally allowing for large-scale investigation of brain metabolism mechanisms in humans and potentially leading to new drug and behavioral intervention discovery to prevent and treat AD.

PI_NAMEs: LEE, PHIL ;TAYLOR, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Acute;Adenosine Triphosphate;Adult;Advanced Development;Age;age effect;Aging;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapy;Antioxidants;Behavior Therapy;beta-Hydroxybutyrate;Bioenergetics;Biological Markers;Brain;brain dysfunction;brain health;brain metabolism;Brain region;Clinical;Coenzymes;Cognition;cognitive function;Data;Databases;design;Development;Diet;effective intervention;Energy Metabolism;experimental study;feeding;Future;Glucose;Glutathione;Heart;Human;Image;Impairment;improved;in vivo;Individual;Inflammatory;Infrastructure;Institutional Review Boards;Interdisciplinary Study;Intervention;Intervention Trial;Investigation;ketogenic diet;Ketones;Ketosis;Link;Longevity;Magnetic Resonance Spectroscopy;Measurement;Measures;Metabolic;Methods;Mitochondria;mitochondrial metabolism;Multi-Institutional Clinical Trial;NADH;neuroimaging;neuroimaging marker;Nicotinamide adenine dinucleotide;novel therapeutics;older adult;Outcome;Oxidation-Reduction;Participant;Phase;Phosphocreatine;Physiological;Positron-Emission Tomography;prevent;Prevention;Prevention strategy;Production;Protocols documentation;Randomized;randomized, clinical trials;Readiness;Research;response;Scanning;successful intervention;Techniques;Testing;Therapeutic;therapeutic lifestyle change;Time;uptake;Validation;Work

PROJECT_TITLE: Investigating Neuroenergetic Changes through Diet in Aging and Alzheimer’s Disease (INC-AD)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-2 (J1)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Alzheimer's disease (AD) is the most common type of dementia and one of the leading causes of mortality worldwide. However, available medications provide short-term symptomatic effects but do not cure the disease elluminating an urgent need in discovery and targeting new therapeutically actionable mechanisms underlying the disease. To address this unmet medical need, this project will define the protein-protein interaction between p38 and MK2 as a new target mechanism to control neuroinflammation, the major AD hallmark, and provide the first small molecules to control this pathogenic axis.

PI_NAMEs: IVANOV, ANDREY  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: Address;Affect;Affinity;Agreement;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease therapeutic;Binding;Biochemical;Biological Assay;Brain;Cause of Death;Cells;chemical property;chemokine;Chronic;Clinical;Clinical Research;Clinical Trials;Code;Complex;computational platform;Computer Analysis;Computer Models;cytokine;Data;Dementia;design;Dimethyl Sulfoxide;Disease;disease phenotype;experience;Failure;Fluorescence Resonance Energy Transfer;Goals;high throughput screening;Hour;In Vitro;in vitro Assay;in vivo;Individual;Inflammation;Inflammatory;inhibitor;Interleukin-1 beta;Interleukin-6;kinase inhibitor;Lead;Literature;Mammalian Cell;MAPKAPK2 gene;Medical;mimetics;miniaturize;Mitogen-Activated Protein Kinases;Morphology;mortality;Mus;neuroinflammation;neuron loss;Neurons;new therapeutic target;novel;novel strategies;novel therapeutics;Organoids;p38 Mitogen Activated Protein Kinase;Pathogenicity;Pathologic;Pathway interactions;Peptides;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;physical property;Play;Production;protein complex;Protein Inhibition;Protein Isoforms;Protein Kinase;protein protein interaction;Proteins;Regulation;response;Role;side effect;Signal Transduction;Site;small molecule;small molecule inhibitor;Solid;Stimulus;Stress;Structure;success;Synapses;targeted treatment;Testing;Therapeutic;therapeutic development;Time;Tissues;TNF gene;treatment response;Validation;virtual screening

PROJECT_TITLE: Targeting p38/MK2 protein-protein interaction to control neuroinflammation in Alzheimer's Disease

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Methods for developing new antibiotics are urgently required to address the growing rise of antibiotic resistance mechanisms. We propose to leverage our recent advances in computational peptide design and integrate them with high-throughput chemical synthesis to develop inhibitors of a validated antimicrobial target – the type 1 bacterial signal peptidase. The computational and experimental methods developed in this project will be broadly applicable to developing superior analogs of naturally-occurring antibiotics and rationally designing new classes of antibiotics.

PI_NAMEs: BHARDWAJ, GAURAV  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Active Sites;Address;Affinity;Algorithm Design;Amino Acid Sequence;Amino Acids;analog;antibiotic design;Antibiotic Resistance;Antibiotics;antimicrobial;Bacterial Proteins;Binding;Biological Assay;Biological Availability;Cell membrane;Cell Survival;chemical synthesis;Chemicals;Computer Models;Computing Methodologies;Custom;Cyclic Peptides;deep learning;denoising;design;Development;Diffusion;Docking;emerging antibiotic resistance;emerging antimicrobial resistance;Experimental Models;extracellular;Extracellular Protein;Fluorescence Resonance Energy Transfer;Goals;Growth;high throughput screening;in silico;Individual;inhibitor;iterative design;Learning;Libraries;Mammalian Cell;Mass Spectrum Analysis;Medical;member;Methods;Minimum Inhibitory Concentration measurement;model design;Modeling;Molecular Conformation;nanomolar;Natural Products;novel antibiotic class;novel strategies;Oral;parallel computer;pathogen;pathogenic bacteria;Peptide Hydrolases;peptide structure;Peptides;periplasm;Periplasmic Proteins;Permeability;Pharmaceutical Preparations;Physics;Play;Positioning Attribute;Property;Protease Inhibitor;Protein Engineering;Proteins;rational design;Research;resistance mechanism;Role;Sampling;scaffold;screening;secondary metabolite;Shapes;signal peptidase;small molecule libraries;Staphylococcus aureus glutamic acid-specific endopeptidase;Structure;Testing;Toxic effect;Validation;Variant;Vertebral column

PROJECT_TITLE: Computational de novo design of macrocyclic type I Signal Peptidase inhibitors

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: EL PASO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

ORG_STATE: TX

PHR: Project Narrative The proposed work is a proof-of-concept study in vivo for the development of a novel gene therapy for melanoma. Functionalized lipid nanoparticles can transfect melanoma cells selectively in mice, and deliver a gene that causes melanoma cells to express a-Gal, which is antigenic. This makes the melanoma cells susceptible to destruction by anti-a-Gal Ab-mediated mechanisms.

PI_NAMEs: MICHAEL, KATJA  (contact)

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: Active Biological Transport;adaptive immune response;Adaptive Immune System;Adjuvant;anti-cancer;Antibodies;antibody inhibitor;antibody-dependent cell cytotoxicity;Antigen-Presenting Cells;Antigens;aqueous;arm;Autologous;Biological Assay;bioluminescence imaging;Biomedical Engineering;Cancer Biology;cancer cell;cancer type;Cell membrane;Cell surface;Cell-Mediated Cytolysis;Cells;Cessation of life;Chagas Disease;Charge;checkpoint therapy;Chemistry;Code;Colorectal Cancer;Complement;Complement-Dependent Cytotoxicity;Complementary DNA;Cytolysis;delivery vehicle;Development;Diagnosis;Diameter;Disease;DNA;Effectiveness;Encapsulated;Enzyme-Linked Immunosorbent Assay;Enzymes;Epitopes;Evaluation;experience;Family suidae;folate-binding protein;Folic Acid;Fos-Related Antigens;Galactosyltransferases;gene therapy;gene-targeted therapy;Genes;Genetic Transcription;Glycoengineering;Glycolipids;Glycoproteins;Histopathology;Hour;Human;Immune checkpoint inhibitor;Immune response;Immune system;Immunization;immunogenic;immunogenicity;Immunoglobulin G;Immunologics;Immunotherapy;implantation;In Vitro;in vivo;in vivo evaluation;Incidence;indexing;Injections;innate immune mechanisms;Innate Immune System;Kidney;Kidney Transplantation;Knockout Mice;Lesion;Ligands;lipid nanoparticle;Lipids;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Mediating;melanocyte;Melanoma;Melanoma Cell;Melanoma Vaccine;Metastatic Melanoma;Microscopy;Monitor;mouse model;Mus;nanoparticle delivery;Nanotechnology;Neoplasm Metastasis;novel;Organ;Outcome;overexpression;Parasites;Patients;Peptides;Phagocytosis;Phase I Clinical Trials;Play;Predisposition;promoter;receptor;Role;Serum;side effect;Slice;Surface;TFRC gene;Th1 Cells;Th2 Cells;therapeutic vaccine;Tissues;Toxic effect;Transfection;Transferase;Trypanosoma cruzi;tumor;Tumor Antigens;tumor growth;Tumor Immunity;uptake;Vaccines;Visual;Work;Xenograft procedure

PROJECT_TITLE: A novel gene-based immunotherapy inducing melanoma destruction

STUDY_SECTION: TIO

STUDY_SECTION_NAME: Translational Immuno-oncology Study Section[TIO]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Depression;Disability Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE People with living with a vision impairment (VI) are not immune to problems engaging in routine physical activity and exercise necessary for health benefits and in fact, research shows that this vulnerable population is disproportionally at greater risk for physical inactivity, sedentary behaviors, and subsequent chronic health complications (e.g., obesity; hypertension; cardiovascular disease) compared to those with adequate vision. To urgently address this health disparity, an evidence-based physical activity behavior change intervention will be modified and evaluated to motivate and empower people with a VI to gradually increase physical activity behaviors to levels associated with health benefits and the prevention of secondary health conditions. Individuals with a VI will improve physical activity duration and intensity which will positively impact their everyday functioning, emotional well-being, sleep quality, vision-related quality of life, and social participation.

PI_NAMEs: DREER, LAURA E (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Accelerometer;Address;Adult;Advocacy;African American;Aftercare;Agreement;Behavior;behavior change;Blindness;Body mass index;Cardiovascular Diseases;Chronic;Client satisfaction;Communities;Consensus;Data;Data Collection;depressive symptoms;Diagnosis;disability;Drops;empowerment;evidence base;Exercise;exercise adherence;exercise intervention;experience;Experimental Designs;Eye diseases;Face;Family;feasibility testing;Feedback;field study;follow-up;Frequencies;Friends;Health;Health behavior;Health Benefit;health disparity;Health Expenditures;Health Promotion;Health Services;healthy lifestyle;Household;Hypertension;implementation intervention;improved;Income;Individual;Intellectual functioning disability;interest;Intervention;Life Style;Link;Literature;Maintenance;Measures;Mental Depression;Methodology;Morbidity - disease rate;Motivation;Obesity;Outcome;Overweight;Participant;Patients;peer support;Perception;Persons;Physical activity;Physical Exercise;physical inactivity;physically handicapped;Policies;poor sleep;Population;post intervention;premature;primary outcome;Process;programs;Protocols documentation;Public Health;Quality of life;Readiness;Recommendation;recruit;Research;Research Support;Risk;Risk Reduction;Sampling;satisfaction;Secondary Prevention;sedentary lifestyle;Self Efficacy;Services;Severities;sleep quality;social engagement;Social isolation;therapy development;Time;Treatment Efficacy;unhealthy lifestyle;Vision;Visual impairment;Vulnerable Populations;Weight;Weight Gain;Weight maintenance regimen;Well in self

PROJECT_TITLE: Addressing Physical Activity Among Adults with Vision Impairment

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

ORG_STATE: CA

PHR: Project Narrative We propose to design and evaluate a front-end, analog application specific integrated circuit (ASIC) that translates the ultra-fast timing performance of a gold-standard, benchtop readout chain for silicon photomultipliers (SiPMs) into an implementation that is tractable for large scale imaging systems (thousands of channels of electronic readout), to advance time-of-flight positron emission tomography imaging. This electronic readout chain leverages a first-ever implementation of a capacitance compensation scheme into an SiPM readout ASIC, thereby mitigating the large device capacitance exhibited by SiPMs and providing a pathway for realizing benchtop timing performance for SiPM-based detectors in large scale imagers and experiments.

PI_NAMEs: CATES, JOSHUA WILLIAM (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TITLE: Electronic Readout for Next-Generation Ultra-Fast Time-of-Flight Positron Emission Tomography Systems

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Narrative This project will explore the etiology of Antisynthetase Syndrome (ASSD) - a chronic autoimmune disorder char- acterized by myositis and interstitial lung disease (ILD) and the presence of autoantibodies against aminoacyl- tRNA synthetases (aaRSs) - and generate a novel and clinically relevant animal model for mechanistic study and future therapeutic development.

PI_NAMEs: KANAJI, TAISUKE ;YANG, XIANG-LEI  (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Adjuvant;Amino Acids;Amino Acyl-tRNA Synthetases;Animal Model;Antibodies;Antigen-Antibody Complex;Autoantibodies;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;Binding;Biological Assay;Blood Circulation;Cell Culture Techniques;Cell Line;Cell model;Cell secretion;Cells;Chronic;chronic autoimmune disease;Circulation;Clinical;clinically relevant;Cytoplasmic Protein;Data;Dendritic Cells;Disease;disease phenotype;Endoplasmic Reticulum;Endosomes;Enzymes;Epithelial Cells;Etiology;extracellular;extracellular vesicles;Functional disorder;Future;Generations;Genes;Golgi Apparatus;Histidine-Specific tRNA;Histidine-tRNA Ligase;Human;Immune;Immune response;Immunize;In Vitro;in vivo;Inflammation;Inflammatory;Interferon Type I;Interstitial Lung Diseases;Knockout Mice;Ligands;Ligase;Lung;Lymphocytic choriomeningitis virus;Macrophage;Mediating;Modeling;Monitor;mouse model;Mus;Muscle;Myositis;new therapeutic target;NF-kappa B;novel;Pathogenesis;Pathway interactions;Patients;Peptide Signal Sequences;Pilot Projects;Play;Process;Proteins;receptor;Receptor Activation;Receptor Signaling;Reporter Genes;RNA;Role;Sampling;Signal Transduction;Source;Stress;Surface;Symptoms;Syndrome;Testing;therapeutic development;TLR7 gene;Toll-like receptors;Transfer RNA;Translations;type I interferon receptor;Virus Diseases;Work

PROJECT_TITLE: Explore the involvement of tRNA in the pathophysiology of antisynthetase syndrome

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: IRVINE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Population establishment and spread of Anopheles stephensi mosquito in Africa pose major challenges for malaria control and elimination in Africa. Sensitive surveillance of An. stephensi is critical to its early detection and control. The new serological surveillance tools to be developed by this project will distinguish the exposure of invasive An. stephensi from the native African malaria vector species, and thus greatly support the surveillance and control of An. stephensi in Africa.

PI_NAMEs: WANG, XIAOMING CHLOE;YAN, GUIYUN  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Africa;African;Americas;Anopheles Genus;Antibodies;Antibody Response;Area;Asia;Binding;Bioinformatics;Biological Markers;Bite;Blood;Culicidae;design;Detection;detection sensitivity;Djibouti;Domestic Animals;Dose;Early Diagnosis;Enzyme-Linked Immunosorbent Assay;Ethiopia;experience;exposed human population;Exposure to;Health;Horns;Human;Human Volunteers;immunogenicity;Immunoglobulin G;improved;Individual;Insecticides;Invaded;Light;Malaria;malaria mosquito;malaria transmission;Measurement;Measures;Methods;Microarray Analysis;Middle East;Monitor;Nigeria;novel;Outcome;Peptides;Plasma;Plasmodium falciparum;Plasmodium vivax;Pollution;Population;Printing;Protein Microchips;Proteins;Research;Resistance;response;Role;Salivary;Salivary Glands;Salivary Proteins;Sampling;Sensitivity and Specificity;Serology;serosurveillance;Site;Somalia;Source;Southeastern Asia;specific biomarkers;Specificity;Sudan;Surveillance Methods;tool;transmission process;urban setting;vector;volunteer;World Health Organization

PROJECT_TITLE: Serological Biomarkers for Monitoring Human-Vector Contact by Invasive Anopheles stephensi in Africa

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

PHR: Narrative This proposal takes host Caspase-1 beyond the well-studied inflammasomes and ties it to signal transduction, physiology and antimicrobial resistance of an intracellular pathogen.

PI_NAMEs: AKHADE, AJAY SURESH (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Abbreviations;Antibiotics;Antimicrobial Cationic Peptides;Antimicrobial Resistance;arm;arms race;Attention;Bacteria;Bacterial Infections;bacterial resistance;Bacterial RNA;Binding;CASP1 gene;Caspase;Cell Death Induction;Cells;combat;Complex;Cues;Defense Mechanisms;Dissection;Down-Regulation;Flagellin;Gene Expression;Genes;Grant;Healthcare;Host Defense;Host Defense Mechanism;Immune;immune activation;Immune response;Infection;Inflammasome;Inflammatory;insight;Integration Host Factors;Interferons;Invaded;Investigation;Length;Lysophospholipids;Macrophage;Mediating;Mediator;Modeling;Molecular;novel;pathogen;Pathogenicity;Pathway interactions;Peptide Hydrolases;Phagosomes;Pharmaceutical Preparations;Phase;Physiology;Polymyxin B;Predisposition;Process;Regulation;Resistance;response;restraint;Role;Salmonella;Signal Transduction;System;Technology;Vacuole;Virulence

PROJECT_TITLE: A non-canonical role of Caspase-1 in regulating bacterial antimicrobial resistance

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: Mark Ilgen, Ph.D. is a productive Department of Veterans Affairs Health Services Researcher who is recognized nationally as a leader in the area of Addiction Health Services Research and is dedicated to improving care for Veterans with Substance Use Disorders (SUDs). His work is designed to enhance positive treatment outcomes and reduce potential adverse events for Veterans with SUDs, particularly for those who have comorbid pain or who are at increased risk of suicide. The proposed Research Career Scientist Award will support his continued research to enhance care for Veterans, as well as an expanded role in mentorship and training of early career scientists as the next generation of VHA health services researchers and leaders.

PI_NAMEs: ILGEN, MARK A. (contact)

PROJECT_TERMS: abuse liability;addiction;Address;Adverse event;adverse event risk;Alcohols;Area;Award;behavioral health;brief intervention;Budgets;career;Caring;chronic pain;Clinical;clinical center;Clinical Management;Collaborations;Communities;comorbidity;Databases;Dedications;Department of Defense;design;Development;Doctor of Philosophy;Epidemiologist;Evaluation;evidence base;Family;Funding;Future;Grant;Health;Health Personnel;Health Services;Health Services Administration;Health Services Research;high risk;Homelessness;implementation study;Improve Access;improved;innovation;Institution;International;Intervention;Investments;Leadership;Link;Medical;member;Mental Health;Mentors;Mentorship;Methods;National Institute of Drug Abuse;next generation;Opioid;opioid epidemic;Outcome;Overdose;Pain;Pain management;Patients;Peer Review;Pharmaceutical Preparations;Physicians;Positioning Attribute;Productivity;Program Evaluation;Psychologist;Publications;Publishing;randomized trial;Research;research and development;Research Design;Research Personnel;Research Priority;Resources;Risk;Risk Factors;Risk Reduction;Role;Safety;Scientist;Services;severe mental illness;Site;Structure;Substance Use Disorder;suicidal risk;Suicide;Suicide prevention;System;telehealth;Testing;Training;Treatment outcome;United States National Institutes of Health;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: HSR&D Research Career Scientist Award

STUDY_SECTION_NAME: HSR-7 Capacity Building[HSR7]


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE for ARTFL LEFFTDS Longitudinal FTLD PROGRAM The ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) protocol represents an expanded and integrated program involving seven cores and two projects with the intent of increasing data/samples/scans for investigative research in familial and sporadic FTLD, and ultimately promoting the development of effective therapies. The proposed project will enroll 2100 participants across 19 sites in the US and Canada, and by using the infrastructure built during the Advancement of Research and Treatment in Frontotemporal Lobar Degeneration (ARTFL) and Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS) protocols, the ALLFTD cores will generate data that will be uploaded to the National Alzheimer’s Coordinating Center (NACC), biofluid samples that will be transferred to and processed at National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD), and imaging data that will be transferred to the Laboratory of NeuroImaging (LONI) - thereby providing data to qualified researchers worldwide. The cores will also contribute data and expertise to the projects, which will focus on asymptomatic/minimally symptomatic familial FTLD (Project 1) and overtly symptomatic familial and sporadic FTLD (Project 2).

PI_NAMEs: BOEVE, BRADLEY F (contact);BOXER, ADAM L.;ROSEN, HOWARD J

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Address;Age;Age of Onset;Alzheimer's Disease;Alzheimer's disease related dementia;American;Biological;Biological Markers;C9ORF72;Canada;Clinical;Clinical Data;Clinical Sciences;Clinical Trials;Clinical Trials Design;Clinical Trials Network;cohort;Collection;Communities;Data;Data Collection;data management;Data Set;data sharing;Databases;Deposition;Development;Diagnosis;diagnostic accuracy;Disease;Disease Progression;DNA;DNA-Binding Proteins;effective therapy;Enrollment;Evaluation;Familial disease;Family;Fostering;frontotemporal degeneration;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Funding;gene product;Genes;Genetic;Genomics;genotyped patients;Goals;Grant;Heterogeneity;Image;improved;Industry;Infrastructure;Inherited;International;Laboratories;Liquid substance;MAPT gene;Measures;meetings;Microtubule-Associated Proteins;Molecular Weight;MRI Scans;Mutate;Mutation;Natural History;Neurodegenerative Disorders;neuroimaging;neuropathology;North America;novel therapeutics;Participant;patient advocacy group;Patients;Peripheral Blood Mononuclear Cell;PGRN gene;Phenotype;Plasma;Preparation;Process;programs;protein aggregation;Protocols documentation;Publications;Qualifying;Recommendation;Recording of previous events;recruit;Registries;repository;Research;Research Personnel;Research Project Grants;Sampling;Scanning;Site;Study Subject;Symptoms;Syndrome;Tissues;United States National Institutes of Health


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: BOEVE, BRADLEY F (contact)

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;California;Clinical;Clinical Data;Clinical Trials;cohort;Collaborations;Collection;Communication;Communities;Data;Data Set;data sharing;Dementia;diagnostic tool;Disease;DNA;Education;Enrollment;Ensure;Evaluation;Family;Fostering;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Funding;Genetic;Goals;Grant;Image;Indiana;Industry;industry partner;Infrastructure;International;Internet;Laboratories;meetings;Messenger RNA;Methodology;Methods;Modeling;MRI Scans;National Center for Advancing Translational Sciences;National Institute of Neurological Disorders and Stroke;Natural History;Neurodegenerative Disorders;neuroimaging;neuropathology;Neuropsychology;North America;outreach;Participant;participant safety;patient advocacy group;Patients;Peripheral Blood Mononuclear Cell;Personnel Management;Phenotype;Plasma;Procedures;Process;programs;Protocols documentation;Quality Control;Recommendation;recruit;repository;Research;Research Personnel;Research Priority;Sampling;Scanning;Serum;Site;Specimen;Standardization;Structure;success;symposium;trial planning;United States National Institutes of Health;Universities;Update;Visit;Washington;Work

PROJECT_TITLE: Administrative Core


PROJECT_TERMS: Address;advanced directive;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;arm;Autopsy;Basic Science;Biological Markers;C9ORF72;California;Categories;Clinical;Clinical Data;Clinical Sciences;Clinical Trials;Clinical Trials Network;cohort;Communities;Data;Data Set;data sharing;design;Development;Diagnosis;Disease;Disease Progression;DNA;Enrollment;Evaluation;Family member;Fostering;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Funding;Genes;genotyped patients;Goals;Heterogeneity;Impairment;Indiana;Infrastructure;International;kindred;Laboratories;member;Messenger RNA;MRI Scans;Mutation;National Center for Advancing Translational Sciences;National Institute of Neurological Disorders and Stroke;Natural History;neuroimaging;Neuropsychology;North America;Participant;participant enrollment;Patient Recruitments;Patients;Periodicals;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Population;Preparation;Procedures;Process;programs;Protocols documentation;Quality Control;Questionnaires;Recommendation;recruit;Registries;repository;Research;Research Personnel;Research Priority;Sampling;Scanning;Serum;Site;Standardization;Study Subject;success;symposium;tool;Uncertainty;Universities;Update;Washington

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

PI_NAMEs: KREMERS, WALTER K. (contact)

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Back;Behavior assessment;Biological;Biological Markers;Blood;Brain;Cerebrospinal Fluid;Clinical;clinical center;Clinical Data;cognitive testing;Collaborations;Collection;Communities;Complex;Data;Data Analyses;data exchange;data management;data repository;data sharing;Data Storage and Retrieval;Databases;Derivation procedure;Development;Disease;electronic data;Eligibility Determination;Enrollment;Frontotemporal Lobar Degenerations;Funding;Future;Genetic;Goals;high risk;Housing;Image;improved;Infrastructure;Laboratories;Liquid substance;Measurement;Measures;member;Methodology;Methods;Modeling;Mutation;neuroimaging;neuropathology;Neuropsychology;Participant;Patients;Persons;Protocols documentation;Psychometrics;recruit;Registries;relational database;Reporting;repository;Research;Research Design;Research Personnel;Sampling;Secure;Symptoms;Time;tool;tool development;treatment trial;Work

PROJECT_TITLE: Data Management and Statistical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

PI_NAMEs: BOXER, ADAM L. (contact)

PROJECT_TERMS: Academia;accurate diagnosis;Address;Alzheimer's disease related dementia;autosomal dominant mutation;behavioral variant frontotemporal dementia;biobank;Biological Markers;biomarker discovery;Blood;Blood specimen;C9ORF72;carrier status;Cataloging;Cell Line;Clinic;Clinical;clinical trial participant;Clinical Trials;Collaborations;Collection;Communities;Complement 3b;Data;data management;data sharing;Database Management Systems;Databases;Diagnosis;Dipeptides;Disease;DNA;drug discovery;Early Diagnosis;Equipment and supply inventories;Experimental Models;Family;Frontotemporal Lobar Degenerations;Genes;Goals;High Prevalence;high throughput screening;IL18 gene;improved;induced pluripotent stem cell;Industry;Industry Collaboration;Inflammatory;Interleukin-6;Intervention;intervention effect;Life;Light;Liquid substance;Measurement;Measures;Messenger RNA;Monitor;Mutation;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;neurofilament;new therapeutic target;novel;Participant;Pathologic;Pathology;Patients;Peripheral Blood Mononuclear Cell;PGRN gene;pharmacodynamic biomarker;Plasma;Population;Prevention trial;Proteins;Qualifying;repository;Research Personnel;Role;sample collection;Sampling;Sensitivity and Specificity;Serum;Specimen;Standardization;Stratification;Syndrome;System;tau Proteins;Therapeutic;therapeutic biomarker;therapeutic development;therapeutic target;TNF gene;tool;treatment effect;Washington

PROJECT_TITLE: Biofluid Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences

PI_NAMEs: RADEMAKERS, ROSA  (contact)

PROJECT_TERMS: accurate diagnosis;Aging;Alzheimer's Disease;American;Bioinformatics;Blood;C9ORF72;causal variant;Classification;Clinical;clinical subtypes;cohort;Communities;Copy Number Polymorphism;cost;Custom;Data;Data Set;design;Dideoxy Chain Termination DNA Sequencing;Disease;disease model;Distant;DNA;Early Diagnosis;Enrollment;Ethnic Origin;Etiology;experimental study;Family;follow-up;Frontotemporal Lobar Degenerations;Functional disorder;Funding;Future;gene discovery;Gene Mutation;Generations;Genes;Genetic;genetic analysis;genetic association;Genetic Enhancement;Genetic Risk;genetic risk factor;Genetic study;genome analysis;genome sequencing;genome wide association study;genome-wide;genomic data;Genomics;Genotype;Goals;Guidelines;Heterogeneity;Image;Immune system;Immune System Diseases;improved;Individual;kindred;Knowledge;Laboratories;Manuals;MAPT gene;Measures;Medical Genetics;medical schools;member;Molecular Genetics;Mutation Analysis;mutation screening;mutational status;Natural History;Nerve Degeneration;neurodegenerative dementia;Neurodegenerative Disorders;novel;Participant;Pathologic;Pathology;Pathway interactions;Patient Recruitments;patient stratification;Patients;PGRN gene;Phenotype;polygenic risk score;Population;programs;Progressive Supranuclear Palsy;protein TDP-43;Protocols documentation;Publishing;Research;Research Personnel;Resources;Risk;Sample Size;Sampling;SCA2 protein;Single Nucleotide Polymorphism;Site;Statistical Data Interpretation;tau mutation;tau Proteins;Testing;Trinucleotide Repeat Expansion;U-Series Cooperative Agreements;United States National Institutes of Health;Validation;Variant;variant of unknown significance;whole genome;Work

PROJECT_TITLE: Genetics Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

PI_NAMEs: KANTARCI, KEJAL  (contact)

PROJECT_TERMS: Alzheimer's Disease;Biological Markers;Brain;Brain imaging;C9ORF72;catalyst;Clinical;clinical research site;Clinical Trials;Clinical Trials Cooperative Group;cohort;Communities;Confidentiality of Patient Information;Consult;Data;Data Analyses;data management;data sharing;Dementia;design;Diagnosis;diagnostic criteria;Diffusion;Disease;Ensure;Ethics;experience;Frontotemporal Lobar Degenerations;Functional Magnetic Resonance Imaging;Funding;Future;Genes;Genetic;Goals;Image;Image Analysis;image archival system;image processing;imaging biomarker;imaging study;Imaging technology;Individual;innovation;innovative technologies;Laboratories;Leadership;Light;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Measures;MRI Scans;multimodality;mutation carrier;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;neuropathology;Participant;Patients;Perfusion;Pharmaceutical Preparations;Preparation;Procedures;Process;programs;Protocols documentation;Quality Control;Recording of previous events;Research;Research Personnel;Research Project Grants;Resources;Role;Scanning;Site;Staging;Standardization;Symptoms;technology development;Testing;tool;Work

PROJECT_TITLE: Neuroimaging Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Genetics;Human Genome;Infectious Diseases;Orphan Drug;Radiation Oncology;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The research proposed in the project will investigate the molecular mechanisms that cancer cells use to survive radiation therapy. The insights gained from these studies will lead to the development of novel treatment strategies for cancer patients.

PI_NAMEs: GOLDSTEIN, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acetylation;advanced disease;Affect;Aneuploidy;Basic Science;Cancer Biology;cancer cell;Cancer Patient;cancer radiation therapy;cancer therapy;career;Cell Physiology;Cells;Centromere;Chemicals;Chromatids;Chromatin;chromatin modification;Chromatin Remodeling Factor;Chromosome abnormality;Clinical;coping;CRISPR screen;Data;Defect;Dependence;Development;DNA biosynthesis;DNA Damage;DNA Repair;DNA replication fork;Doctor of Philosophy;endonuclease;EP300 gene;Epigenetic Process;epigenomics;Exhibits;gene product;Genetic Transcription;Goals;Head and Neck Cancer;Histone Acetylation;histone methylation;histone modification;Histones;homologous recombination;HPV positive;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;improved;in vivo;Incidence;Infection;insight;Investigation;irradiation;Laboratory Research;Laboratory Study;Link;Locally Advanced Malignant Neoplasm;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mentorship;Microtubules;Mitosis;Mitotic;Mitotic spindle;Molecular;mouse model;Nonhomologous DNA End Joining;novel;novel strategies;Outcome;p53-binding protein 1;Pathway interactions;Patients;Play;Predisposition;Protein Acetylation;protein complex;Proteins;Radiation;Radiation Induced DNA Damage;Radiation Oncology;radiation response;Radiation therapy;recruit;Recurrence;Relapse;Research;Research Personnel;Resolution;response;Role;Salvage Therapy;segregation;Signal Pathway;Signal Transduction;Site;Survival Rate;targeted treatment;Techniques;Testing;Tissues;Training;treatment strategy;tumor;tumor specificity;ubiquitin-protein ligase;Work

PROJECT_TITLE: Rewiring of epigenetic DNA damage response pathways in HPV-induced cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE We utilize an innovative multimodal neuroimaging approach to better understand how sleep disturbances and brain networks that regulate emotion may underlie the clinically distressing and economically relevant problem of neuropsychiatric symptoms in those with mild cognitive impairment and Alzheimer’s dementia. The findings will provide a foundation for developing sleep based, mechanism-focused preventative strategies and treatments for neuropsychiatric symptoms in Alzheimer’s dementia that are personalized for the individual.

PI_NAMEs: GOLDSTEIN-PIEKARSKI, ANDREA  (contact)

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: actigraphy;active control;Acute;Affective;Aftercare;Agitation;Alzheimer's Disease;Alzheimer's disease patient;Amygdaloid structure;Anxiety;Area;arm;Basic Science;Behavior Therapy;Behavioral;Behavioral Symptoms;Belief;Biological Assay;Brain;brain dysfunction;causal model;Chronic;Clinical;Clinical Trials;Cognitive Therapy;Communities;Dementia;density;Development;diaries;Distress;Education;Electroencephalography;Eligibility Determination;emotion regulation;emotional distress;emotional experience;Emotions;Enrollment;Equipment and supply inventories;experience;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Generations;high risk;Home;Impairment;improved;improvement on sleep;indexing;Individual;innovation;Intervention;Maintenance;Measures;Mediating;Mental Depression;Methodology;Methods;mild cognitive impairment;Modeling;multimodal neuroimaging;neuropsychiatric symptom;neuropsychiatry;Participant;Patient Self-Report;Patients;performance site;personalized medicine;Physiological;Prefrontal Cortex;Prevention strategy;Preventive treatment;Questionnaires;Randomized;reduce symptoms;restoration;Sampling;screening;Severities;Signal Transduction;Sleep;Sleep Architecture;Sleep Deprivation;Sleep disturbances;sleep health;sleep pattern;Sleeplessness;Stimulus;symptomatic improvement;Symptoms;targeted treatment;Testing;theories;trial design

PROJECT_TITLE: Sleep Disturbance and Emotion Regulation Brain Dysfunction as Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Dementia


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

PI_NAMEs: SEELEY, WILLIAM W (contact)

PROJECT_TERMS: Alzheimer's Disease;Anatomy;Autopsy;Biological;Biological Markers;Brain;Brain Diseases;British Columbia;C9ORF72;candidate validation;Classification;Clinic;Clinical;clinical research site;Collaborations;Communities;Complex;Consensus;Data;Data Collection;data management;data standards;Databases;design;Diagnosis;Diagnostic;Differential Diagnosis;Disease;Drug or chemical Tissue Distribution;Enrollment;Equipment and supply inventories;Event;Financial Support;Freezing;Frontotemporal Lobar Degenerations;Future;Genes;Genetic;Goals;Human;Image;immunoreactivity;interest;Leadership;Link;Location;Methods;Molecular;Mutation;Neuroanatomy;Neurodegenerative Disorders;neuroimaging;Neurologist;neuropathology;Neurosciences;novel;Participant;Pathogenicity;Pathologic;Pathology;Patients;Pilot Projects;Process;protein TDP-43;Proteins;Qualifying;repository;Research;Research Personnel;Resources;Sampling;Seminal;Site;Specimen;Spinal Cord;success;Syndrome;tau Proteins;Tissues;trend;Universities

PROJECT_TITLE: Neuropathology Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Frontotemporal Dementia (FTD);Genetic Testing;Genetics;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: ROSEN, HOWARD J (contact)

PROJECT_TERMS: Acceleration;Age;Age of Onset;autosomal dominant mutation;Biological Markers;Brain;Brain imaging;brain volume;burden of illness;C9ORF72;Cerebrum;Clinical;Clinical assessments;Clinical Markers;Clinical Trials;Data;Dementia;Deterioration;Development;Diagnosis;Disease;executive function;experience;Family;Frontotemporal Lobar Degenerations;functional decline;Future;Genes;Genetic;Genetic Markers;Genetic Polymorphism;Goals;Image;imaging biomarker;improved;Individual;Intervention;Intervention Studies;Light;Liquid substance;Logistics;Maps;Measurement;Measures;Methods;multimodality;mutation carrier;Neurodegenerative Disorders;neurofilament;Neurons;Neuropsychology;novel;Participant;Patients;Persons;Pharmaceutical Preparations;Plasma;predictive marker;predictive tools;prevent;Prevention;protein biomarkers;Publishing;rate of change;Research;Risk;Sample Size;Severities;Sum;Symptoms;System;Time;treatment choice;treatment effect;trial enrollment;United States National Institutes of Health;verbal;Work

PROJECT_TITLE: Project 1


PROJECT_TERMS: Acceleration;Atrophic;Autoimmunity;Behavioral;behavioral variant frontotemporal dementia;Biological;Biological Markers;Biology;Brain;C9ORF72;Characteristics;Clinical;clinical predictors;clinical trial enrollment;clinical trial readiness;Clinical Trials;Clinical Trials Design;Data;design;Disease;Disease Progression;drug development;Enrollment;Frontotemporal Lobar Degenerations;Future;Genes;Genetic;genetic variant;Goals;Image;immune activation;Immunologic Markers;Impaired cognition;Impairment;improved;Individual;Inflammation;Light;Link;Liquid substance;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Measures;Methods;molecular pathology;molecular targeted therapies;motor disorder;Multi-Institutional Clinical Trial;multimodality;Mutation;neurofilament;neuropathology;North America;Outcome;Outcome Measure;Participant;participant enrollment;Pathology;patient population;Patient Selection;patient stratification;Patients;Pattern;Phenotype;Plasma;polygenic risk score;Population;protein TDP-43;Proteins;rate of change;recruit;response;Risk;Safety;Sample Size;Severity of illness;Surrogate Endpoint;Syndrome;tau Proteins;Testing;Therapeutic;therapeutic target;Time;tool;treatment effect;trial design

PROJECT_TITLE: Project 2


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Biodefense and Related Countermeasures;Biomedical Imaging;Cardiovascular;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Prevention;Social Determinants of Health

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: The COVID-CT Registry is a study to determine if coronary artery disease patients with a history of COVID-19 infection in New York City have more inflammation, resulting in faster development of plaque in their coronary arteries. CAT scans of the heart’s arteries will be used to measure inflammation, stenosis (narrowing of the blood vessels), and plaque (cholesterol deposits) which are all associated with major cardiac events.

PI_NAMEs: NARULA, JAGAT ;SHAW, LESLEE J (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: 2019-nCoV;Acceleration;Acute;Anatomy;Angiography;Area;Arterial Fatty Streak;Atherosclerosis;attenuation;Blood Vessels;Cardiac;Cardiology;Cause of Death;Cholesterol;Clinical;Coronary;Coronary Arteriosclerosis;Coronary artery;coronary computed tomography angiography;COVID-19;COVID-19 mortality;COVID-19 patient;COVID-19 risk;COVID-19 treatment;cytokine;Data Collection;Deposition;deprivation;Development;Diagnostic;Economics;Essential worker;ethnic diversity;Ethnic Origin;Event;experience;Fatty acid glycerol esters;Growth;high risk;Immunology;improved;indexing;Infection;Inflammation;Inflammatory;inflammatory marker;inflammatory milieu;Inflammatory Response;Injury;knowledge base;Laboratories;Laboratory Markers;Link;Measurement;Measures;Methods;mortality;Multicenter Trials;Neighborhoods;New York City;novel;participant enrollment;Pathway interactions;Patients;Physicians;Population Density;post SARS-CoV-2 infection;post-pandemic;Preventive;Preventive care;Process;promoter;psychosocial;Qualifying;Race;racial diversity;Registries;remdesivir;Reporting;Research Personnel;Residual state;Risk;Risk Assessment;Role;SARS-CoV-2 infection;SARS-CoV-2 infection history;Socioeconomic Factors;socioeconomics;Stenosis;systemic inflammatory response;Testing;United States;urban setting;Viral;Virus;Virus Diseases;X-Ray Computed Tomography

PROJECT_TITLE: Mechanistic registry to study whether infection with Corona Virus Disease 2019 (COVID-19) accelerates atherosclerotic plaque progression

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative Tuberculosis (TB) continues to be a major global health problem with 9 million new cases per year resulting in 1.7 million deaths. There will be no lasting reduction of TB morbidity and mortality without rapid and cost-effective therapeutics. The goal of this proposal is to accelerate TB research through the completion and distribution of reagents that allow for precise null gene deletions in Mycobacterium tuberculosis, the causative agent of TB. These valuable resources will be available to the international TB research community.

PI_NAMEs: JACOBS, WILLIAM ROBERT (contact);RIOJAS, MARCO

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Acceleration;Alleles;Attenuated;Bacillus;Bacteriophages;Bar Codes;Biology;Caring;Cessation of life;chemotherapy;Collection;Communities;Containment;cost effective;COVID-19 pandemic;CRISPR library;Data;Developing Countries;Development;Diagnosis;Discipline;DNA;Electroporation;Engineering;Epidemic;Extreme drug resistant tuberculosis;Foundations;Fright;Gene Deletion;Gene Family;Gene Frequency;Gene Targeting;Generations;Genes;Genetic;genetic manipulation;Genome;genome-wide;Genotype;global health;Goals;Growth;health inequalities;HIV;Immunologics;improved;International;knockout gene;M. tuberculosis genome;manufacturing scale-up;Metabolism;Methodology;Molecular Genetics;Morbidity - disease rate;mortality;Multidrug-Resistant Tuberculosis;Mutagenesis;mutant;mycobacterial;Mycobacteriophages;Mycobacterium smegmatis;Mycobacterium tuberculosis;Mycobacterium tuberculosis H37Rv;Nucleotides;null mutation;pathogen;Persons;Phenotype;Physiology;Plasmids;Process;Proteins;Protocols documentation;Publications;Quality Control;Reagent;Recombinants;Research;Research Personnel;Resources;Source;success;therapeutic target;therapeutically effective;therapy development;Tuberculosis;tuberculosis diagnostics;tuberculosis treatment;Vaccines;vector;Virulent

PROJECT_TITLE: Generation of a Complete Set of Precise Null Bar-Coded Deletion Mutants of Mycobacterium tuberculosis


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Aging;Digestive Diseases;Lymphatic Research;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project Narrative Aging decreases mammalian intestinal stem cell (ISC) numbers, function, and regenerative capacity; however, how age-related changes in stromal niche cells contribute to ISC aging remains unknown due to the lack of experimental tools. Here, we develop new heterotypic organoid co-culture systems and novel mouse models to investigate how stromal niche cell aging influences the biology of ISCs. We will further interrogate how short- term dietary methionine restriction can modulate the stromal niche cells to enhance ISC function and intestinal regeneration in aging.

PI_NAMEs: GOTO, NORIHIRO  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Address;Affect;age effect;age related;age related changes;age related decline;aged;Aging;Back;Biology;Cell Aging;Cell Count;cell type;Cells;ChIP-seq;Clinic;Clinical;Coculture Techniques;Complex;conditional knockout;dietary;Dietary Intervention;dietary restriction;Engineering;Enzymes;Epigenetic Process;experimental study;Fibroblasts;Fostering;Gene Deletion;Genes;Goals;Growth;Health;Homocysteine;human old age (65+);Hydrolase;improved;In Vitro;in vitro testing;in vivo;in vivo evaluation;Injury;insight;Intervention;intestinal epithelium;Intestines;Knockout Mice;LGR5 gene;Ligands;Lymphatic Endothelial Cells;Measures;Mediating;Metabolism;Methionine;Methionine Metabolism Pathway;mouse model;Mus;Natural regeneration;novel;old mice;Organoids;Patients;pharmacologic;Population;programs;promoter;Regenerative capacity;Rejuvenation;repaired;Research;Role;Signal Transduction;single-cell RNA sequencing;Sirolimus;skills;Source;stem cell aging;stem cell biology;stem cell function;stem cell homeostasis;stem cell self renewal;stem cells;Stromal Cells;stromal progenitor;Supporting Cell;System;Testing;Time;tool;Training;transcriptome sequencing;Translating;Uncertainty;Visualization

PROJECT_TITLE: Understanding the role of the stromal cell niche in intestinal stem cell aging

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_DEPT: NEUROSURGERY

PHR: PROJECT NARRATIVE There are no biomarkers that are currently used in the management of high-grade gliomas. Therefore, patients are often required to undergo invasive biopsies or surgical resection to differentiate disease progression from treatment related changes, quantify disease burden and track the molecular evolution of these difficult to treat cancers. We will generate a multi-analyte assay based on released tumor DNA in the cerebrospinal fluid to generate personalized biomarkers capable of tracking disease and providing insights into the tumor genotype, thereby allowing clinicians to make more informed decisions in real-time.

PI_NAMEs: BETTEGOWDA, CHETAN  (contact)

PROGRAM_OFFICER_NAME: FU, SIDNEY WANG

PROJECT_TERMS: Alleles;Benchmarking;Biological Assay;Biological Markers;Biopsy;Blood;Body Fluids;Brain;burden of illness;cancer biomarkers;cancer cell;Cancer Patient;Caring;cell free DNA;Cerebrospinal Fluid;chemotherapy;Clinical;cohort;Data;Detection;Development;Diagnosis;Diagnostic;diagnostic tool;digital;Disease;Disease Progression;DNA;Dose;driver mutation;Evolution;Excision;exome sequencing;experience;Future;Genomics;Genotype;Glioma;Goals;high risk;imaging modality;improved;Individual;Infection;insight;Karnofsky Performance Status;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;Measures;minimally invasive;Molecular Evolution;Monitor;Multiple Sclerosis;mutant;Mutation;Necrosis;neoplastic cell;neurosarcoidosis;Neurosurgical Procedures;Normal tissue morphology;novel therapeutics;Operative Surgical Procedures;optimal treatments;Outcome;Parents;Pathologic;patient subsets;Patients;personalized biomarkers;personalized therapeutic;Process;Prognosis;Radiation therapy;radiological imaging;Recurrence;Recurrent tumor;Repeat Surgery;Research;Sampling;serial imaging;Somatic Mutation;specific biomarkers;Specific qualifier value;Specificity;Sputum;Steroids;Techniques;Testing;Time;Tissues;treatment effect;treatment response;tumor;Tumor Burden;tumor DNA;tumor progression;Tumor Tissue;Tumor-Derived;Uncertainty;Urine;Work

PROJECT_TITLE: Interrogating malignant gliomas using released tumor DNA in cerebrospinal fluid


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is the leading cause of dementia and a growing health concern associated with brain vascular pathologies. Brain endothelial cells maintain proper structure and function of vasculature, but they become dysfunctional in AD contributing to cognitive impairment and deposition of pathological proteins in the brain. This project aims to understand how APOE, the strongest risk gene for developing AD, impacts the protein changes in endothelial cells in AD individuals and AD mouse model with the ultimate goal to identify new therapeutic targets and biomarkers for treatment of this devastating disorder.

PI_NAMEs: WOJTAS, ALEKSANDRA MARIA (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: abeta accumulation;Abeta clearance;abeta deposition;Acceleration;Affect;Age;Age Months;Age-associated memory impairment;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Amyloid deposition;amyloid pathology;Amyloidosis;Apolipoprotein E;apolipoprotein E-3;APP-PS1;asymptomatic Alzheimer's disease;Autopsy;Biological Markers;Biotin;Biotinylation;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood flow;Blood Vessels;blood-brain barrier permeabilization;Brain;brain endothelial cell;brain parenchyma;Brain region;brain tissue;cell type;Cells;Cerebral Amyloid Angiopathy;Cerebrospinal Fluid;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular pathology;Cerebrovascular system;Collection;Cortical vasculature;Coupled;Cre lox recombination system;Data;Dementia;density;Deposition;Diagnosis;Disease;disease phenotype;Disease Progression;Endothelial Cells;Endothelium;Exhibits;Functional disorder;Genes;Genetic Predisposition to Disease;Genome;genome wide association study;Genotype;Goals;Health;high risk;Histologic;Human;Immunohistochemistry;Impaired cognition;Impairment;in vivo;Individual;innovation;insight;Label;Ligase;Link;Mass Spectrum Analysis;Mediating;Memory;Molecular;mouse model;Mus;Neurodegenerative Disorders;Neurons;new therapeutic target;non-demented;normal aging;novel;Pathologic;Pathology;Pathway interactions;Play;protein aggregation;Proteins;Proteome;Proteomics;religious order study;Research;Resolution;Risk Factors;risk variant;Role;Sampling;sex;single-cell RNA sequencing;Structure;tau aggregation;Techniques;Technology;Testing;therapeutic biomarker;therapeutic target;Tissues;transcriptomics;Variant;Vascular Diseases;Western Blotting;Work

PROJECT_TITLE: Impact of APOE on endothelial cell proteomes in Alzheimer's disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Although neuropsychiatric symptoms (e.g. aggression, psychosis, anxiety, apathy, depression, and sleep disturbances) occur in ~85% of Alzheimer disease patients and are associated with accelerated decline, increased cost, out-of-home placement, and greatly increased suffering of patients and families, our understanding of their etiology is still inadequate, with treatments often being ineffective and even associated with serious adverse effects (including increased mortality). This knowledge gap is particularly egregious in underserved racial and ethnic groups such as Hispanics and African-Americans. We propose to expand the racially and ethnically diverse ADSP-FUS and related resources to include harmonized neuropsychiatric symptom data allowing researchers to assess a variety of additional critical hypotheses, and to utilize these harmonized data to identify ancestry-specific genetic determinants, molecular pathways, and polygenic effects underlying neuropsychiatric symptoms in Alzheimer disease.

PI_NAMEs: BEECHAM, GARY WAYNE;HUEY, EDWARD D;REITZ, CHRISTIANE  (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Acceleration;Address;admixture mapping;Adverse effects;African American;African American population;Aggressive behavior;Agitation;Alzheimer's Disease;Alzheimer's disease patient;Anxiety;Asian;Awareness;Biological Markers;Brain imaging;Candidate Disease Gene;Cognitive;cohort;Cohort Studies;Collection;Complement;cost;Data;data harmonization;Data Set;Dementia;disabling symptom;druggable target;ethnic diversity;Ethnic Population;Etiology;Family;Follow-Up Studies;Future;Genes;Genetic;genetic architecture;Genetic Determinism;Genetic Risk;genetic risk factor;genetic variant;genome resource;genome-wide;Genomic approach;genomic data;Genomic Segment;Genomics;Goals;health disparity;Heritability;Hispanic;Hispanic Americans;Home;improved;in silico;Individual;Knowledge;Latino;Mendelian randomization;Mental Depression;Mental disorders;Modeling;Molecular;mortality;Neuroanatomy;neuropathology;neuropsychiatric symptom;neuropsychiatry;Not Hispanic or Latino;novel;Pathway Analysis;Pathway interactions;Patients;pharmacologic;Pharmacological Treatment;Phenotype;Population;Population Heterogeneity;Process;Psychiatric Diagnosis;Psychoses;racial diversity;racial population;repetitive behavior;Research Personnel;Resources;response;Risk;Role;Sampling;segregation;Severities;Sleep disturbances;Structure;trait;Underserved Population;United States National Institutes of Health;Variant;whole genome

PROJECT_TITLE: Genetic and neuroanatomical basis of neuropsychiatric symptoms in Alzheimer's disease in populations of diverse ancestry


NIH_SPENDING_CATS: Biotechnology;Chronic Obstructive Pulmonary Disease;Emphysema;Genetics;Human Genome;Lung;Prevention;Tobacco;Tobacco Smoke and Health

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative COPD/emphysema, the third leading cause of death in the United States, is a chronic inflammatory lung disorder usually triggered by long-term cigarette smoke exposure. Although many therapies reduce the symptoms of COPD, no interventions exist which arrest or reverse the extensive architectural and functional damage that punctuate the disorder. In this proposal, we examine the mechanisms by which impaired hepatocyte growth factor receptor activity contributes to COPD development and whether enhancing the activity of this receptor and its pathway effects will attenuate acquired lung injury.

PI_NAMEs: NEPTUNE, ENID R (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Adult;Alleles;Alveolar;alveolar epithelium;alveolar type II cell;Apoptosis;Apoptotic;Architecture;Attenuated;bronchial epithelium;Cause of Death;Cell Compartmentation;cell type;Cells;Chronic;Chronic Obstructive Pulmonary Disease;cigarette smoke;cigarette smoke-induced;cigarette smoke-induced lung injury;Clinical;cohort;Complex;Data;Development;Disease;Disease susceptibility;Distal;DNA Methylation;Dose;Down-Regulation;Elastases;Epigenetic Process;Epithelial Cells;Epithelium;Exposure to;exposure to cigarette smoke;gain of function;Gene Expression Regulation;Genes;Genetic;Genetic study;genetic variant;genome sequencing;genome-wide analysis;Growth Factor Receptors;hepatocyte growth factor activator;HGF gene;Homeostasis;Human;human disease;Impairment;Incidence;Inflammatory;injured;Injury;Intervention;Ligands;loss of function;Lung;Lung Diseases;lung injury;Maintenance;Mediating;MET gene;MicroRNAs;miRNA expression profiling;Molecular Profiling;Morphogenesis;morphogens;multiple omics;Mus;Neonatal;Oxidative Stress;Pathway Analysis;Pathway interactions;pharmacologic;Phenotype;Pre-Clinical Model;Predisposition;preservation;prevent;protective effect;Pulmonary Emphysema;pulmonary function;receptor;reduce symptoms;regenerative;Regenerative pathway;Regulation;repaired;Reporting;response;reverse genetics;Role;Sampling;Signal Transduction;skills;Structure of parenchyma of lung;Surveys;Testing;Therapeutic Effect;therapy development;Tissues;Trans-Omics for Precision Medicine;transcriptome sequencing;transcriptomics;United States;Vascularization;whole genome

PROJECT_TITLE: Hepatocyte Growth Factor Signaling and Airspace Maintenance

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Hematology;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Disorders of the blood and bone marrow are of great public health significance. The transcription factor GATA2 is responsible for emergence of the blood and bone marrow during development and maintenance of the bone marrow stem cell compartment in adults, while germline mutations in GATA2 predispose to immunodeficiency and bone marrow failure. Understanding the factors that interface with GATA2 to regulate its functions on chromatin will help us elucidate its role in promoting a healthy bone marrow and inform future therapies for conditions involving the blood and bone marrow.

PI_NAMEs: MATSON, DANIEL R. (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Acetyltransferase;Adult;Advisory Committees;Age;Alveolar;Antibodies;Applied Research;Automobile Driving;Base Sequence;Basic Science;Binding;Biology;Blood;Bone Diseases;Bone Marrow;Bone marrow failure;Bone Marrow Stem Cell;career development;CD34 gene;Cell Compartmentation;Cell Line;Cells;Cellular biology;Chromatin;chromatin immunoprecipitation;Clinical;cohort;Communities;Complex;Coupled;Data;Development;Disease;disease-causing mutation;enhancer-binding protein AP-4;Enhancers;Erythroblasts;Erythrocytes;Erythroid;erythroid differentiation;Erythroid Progenitor Cells;Erythropoiesis;experience;experimental study;Family;Fetal Liver;Foundations;Future;GATA1 gene;Generations;Genes;Genetic Transcription;Genome;Germ Lines;Germ-Line Mutation;Goals;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic stem cells;Hematopoietic System;histone acetyltransferase;Homeostasis;Human;immunodeficiency;Immunoprecipitation;induced pluripotent stem cell;International;K-Series Research Career Programs;Laboratories;Lead;Link;Lower Extremity;Lymphatic;Lymphedema;Maintenance;Malignant - descriptor;Marrow;Mass Spectrum Analysis;Measures;Medicine;member;Mentors;Molecular;Mus;mutant;Mutation;Output;Pathology;Pathway interactions;patient variability;Patients;Penetrance;Phenocopy;Physicians;Physiological;Process;professor;progenitor;programs;Proliferating;protein function;Proteins;Proteomics;Public Health;Reaction;recruit;regenerative biology;Regulatory Element;Repression;Research;Research Personnel;Role;Scientist;Sensorineural Hearing Loss;Site;Specificity;Structure;Symptoms;Syndrome;System;tenure track;Testing;Time;Training Programs;transcription factor;Validation;Variant;Zinc Fingers

PROJECT_TITLE: The Role of the GATA2 Interactome in Erythropoiesis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Infertility;Maternal Health;Pregnancy;Women's Health Research

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Public Health Relevance Statement Uterine angiogenesis is an underlying event of embryo implantation and endometrial decidualization to nourish the embryo until it forms a functional placenta. The proposed study will uncover the indispensable role of fibrillar collagen in endometrial decidualization and angiogenesis during early pregnancy. The outcomes will improve our understanding of decidualization and angiogenesis and will provide opportunities to develop tools for the prevention of adverse pregnancy outcomes such as early pregnancy loss in women.

PI_NAMEs: NALLASAMY, SHANMUGASUNDARAM  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: adverse pregnancy outcome;angiogenesis;Architecture;Biological Assay;Blood Vessels;Cell Differentiation process;Cell Proliferation;Cells;clinically significant;Collagen;Collagen Fiber;Collagen Type V;conditional knockout;confocal imaging;Data;Decidua;Decidual Cell Reactions;Defect;design;Development;Dissection;early pregnancy;early pregnancy loss;Ehlers-Danlos Syndrome;Electron Microscopy;Electrons;Elements;Embryo;Embryo Resorption;Endometrial;Endometrial Stromal Cell;Endometrium;Endothelial Cells;Epithelium;Event;Exhibits;Extracellular Matrix;Extracellular Matrix Proteins;Failure;failure Implantation;Fibrillar Collagen;First Pregnancy Trimester;Functional disorder;Generations;Goals;Growth;Hemorrhage;Human;Hypoxia;Imaging Techniques;Impairment;implantation;improved;In Vitro;in vivo;in vivo Model;Incidence;Invaded;Knockout Mice;Link;Literature;Maternal-Fetal Exchange;mechanotransduction;Mediating;microscopic imaging;Morphology;mortality;mouse model;Mus;Mutation;natural Blastocyst Implantation;Natural Killer Cells;novel;Outcome;Outcome Study;Physiological;Placenta;Placentation;Play;Pregnancy;Pregnancy Complications;pregnancy failure;preimplantation;Prevention;Process;Proliferating;Proteins;public health relevance;Publishing;Reporting;response;Role;second harmonic;second harmonic generation imaging;Signal Pathway;Stromal Cells;Structure;success;Tissues;tool;trophoblast;Uterine hemorrhage;Uterus;Vascular Endothelial Growth Factors;Vascular Permeabilities;Vascular remodeling;Woman;Zebrafish

PROJECT_TITLE: Extracellular Matrix-Mediated Endometrial Decidualization and Angiogenesis

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Data Science;Dissemination and Implementation Research;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE While significant advances in global health have been achieved in recent decades, serious variances in health outcomes persist, especially among children, adolescents and their adult caregivers. The proposed research training program in global health research, entitled “ACHIEVE: Addressing the Research Capacity Gap in Global Child, Adolescent & Family Health Utilizing Implementation and Data Sciences focuses on increasing dissemination and implementation science and data science research capacity in order to address global health challenges affecting children, adolescents and their adult caregiving families; and is designed for Medical Doctors and Post-Doctoral trainees in the United States ) and sub-Saharan Africa. The ultimate goal of the ACHIEVE program is to support the development of a cadre of early career researchers applying dissemination and implementation science and data science research methods to ensure that research on evidence-based practices, interventions, and policies are effectively translated to and used in real-world settings heavily affected by health challenges impacting children, adolescents, and the adults who raise them in low and middle-income countries.

PI_NAMEs: BETANCOURT, THERESA STICHICK;HUANG, KENG-YEN ;MCKAY, MARY MCKERNAN;SSEWAMALA, FRED M (contact);TOZAN, YESIM ;WEINE, STEVAN MERRILL

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: Active Learning;Address;Adolescent;adolescent health;Adult;Affect;Africa South of the Sahara;Asia;burden of illness;Caregivers;Child;Child Health;cohort;Collaborations;Consultations;Country;Data Science;Dissemination and Implementation;dissemination science;Eastern Europe;Emerging Communicable Diseases;Ensure;Equity;Family;Family health status;Funding;global health;Goals;Graduate Degree;Health;health care disparity;health disparity;health inequalities;Health Professional;Healthcare Systems;Immersion;implementation science;Incidence;Knowledge;Learning;Light;low and middle-income countries;Mentors;Mentorship;Methodology;Monitor;Online Systems;Outcome;outcome disparities;Pattern;Population;Populations at Risk;Postdoctoral Fellow;programs;Public Health;Research;Research Methodology;Research Personnel;Research Training;Resource-limited setting;skills;Time;Training;Training Programs;Translations;trend;Universities;uptake;Vulnerable Populations

PROJECT_TITLE: Addressing the Research Capacity Gap in Global Child, Adolescent, & Family Health Utilizing Implementation and Data Sciences


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

PHR: PROJECT NARRATIVE The prevalence of Alzheimer’s disease and related disorders (ADRD) and the associated societal and economic burden is expected to rise as baby boomers enter old age. This problem is particularly salient in African Americans and Latinx who are at higher risk for ADRD than similarly aged non-Latinx Whites. The proposed study will identify biological and social factors that increase and modify risk of ADRD and account for racial/ethnic disparities among middle-aged adults, when ADRD-related pathology begins to manifest in the brain and when intervention may delay or prevent onset.

PI_NAMEs: BRICKMAN, ADAM M;MANLY, JENNIFER JAIE (contact)

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Address;Adult;African American;African American population;Age;age effect;aged;Aging;aging population;aging process;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-42;Atrophic;baby boomer;Biological;Biological Aging;Biological Factors;Biological Markers;biopsychosocial;black men;Black Populations;Black race;black women;Blood;Blood specimen;Blood Vessels;Brain;Buffers;burden of illness;C-reactive protein;cerebrovascular;Cerebrovascular Disorders;Clinical;Cognition;Cognitive;cognitive change;cognitive function;cognitive testing;cohort;cytokine;Data;disorder risk;Disparity;DNA Methylation;Economic Burden;Economics;Education;ethnic difference;ethnic disparity;Ethnic Origin;executive function;follow-up;Functional disorder;Gender;gender disparity;Genetic Risk;Glycosylated hemoglobin A;Health;health determinants;Height;high risk;Hippocampus;human old age (65+);Impaired cognition;Impairment;Individual;Inflammation;Inflammatory;inflammatory marker;Intervention;Language;Latina Population;Latino Population;Latinx;Life;Life Cycle Stages;Light;Lipids;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Mediating;Mediator;Medical;Memory;men;middle age;mild cognitive impairment;MRI Scans;Neighborhoods;Nerve Degeneration;Neuroanatomy;neurofilament;neuropathology;Neuropsychology;offspring;older adult;Parents;Participant;Pathology;Pathway interactions;perceived discrimination;performance tests;Persons;Phase;Plasma;Play;pre-clinical;Prevalence;prevent;promote resilience;psychosocial;Psychosocial Factor;Race;racial difference;racial discrimination;racial disparity;rate of aging;Recording of previous events;recruit;resilience;Risk;Role;Sampling;sex;social;social factors;social health determinants;Socioeconomic Status;Spanish;Structure;tau Proteins;tau-1;Testing;Thick;Thinness;transmission process;Vascular Diseases;Washington;Woman;Work

PROJECT_TITLE: Offspring Study of Mechanisms for Racial Disparities in Alzheimer's Disease


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

PHR: NARRATIVE Many individuals persist in personal behaviors or lifestyle (substance abuse, physical inactivity/obesity) that significantly increase risk for chronic disease and premature death. This relationship between personal behavior and disease risk is firmly established, but much remains to be learned about why certain individuals are more likely to engage in risky behaviors and how to promote behavior change.

PI_NAMEs: HIGGINS, STEPHEN T (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: addiction;Advisory Committees;Applications Grants;Area;Award;Behavior;behavior change;behavioral economics;behavioral health;brain research;career;Centers of Research Excellence;Cessation of life;Chronic Disease;Clinical;clinical care;Clinical Research;Collaborations;college;Complex;contingency management;cost effective;Data;disorder risk;early-career faculty;Education;Environment;evidence base;Faculty;Fostering;Foundations;Funding;Funding Opportunities;Goals;Grant;Growth;Health;Health Promotion;improved;Individual;Industry;innovation;Institution;Interdisciplinary Study;International;Intervention;Journals;Knowledge;Learning;lectures;Life Style;Medical;member;Mentors;multidisciplinary;Nebraska;Neurobiology;next generation;Obesity;Pattern;Peer Review;Periodicals;Personal Behavior;Pharmacological Treatment;Phase;physical inactivity;Pilot Projects;Policies;Positioning Attribute;premature;Preventive Medicine;programs;Publications;Regimen;Research;Research Personnel;Risk;Risk Behaviors;Role;Rural;Schedule;Science;Scientific Advances and Accomplishments;Scientist;senior faculty;Series;sound;Structure;Substance abuse problem;substance misuse;success;symposium;System;Tobacco;Training;United States Health Resources and Services Administration;United States National Institutes of Health;Universities;Vermont;Vulnerable Populations;working group

PROJECT_TITLE: Vermont Center on Behavior and Health


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Advisory Committees;Alcohol consumption;Applications Grants;Area;Attention;Behavior;behavior change;Behavior Therapy;behavioral economics;Budgets;Caliber;career;Centers of Research Excellence;Chronic Disease;clinical practice;Collaborations;Communication;Communities;community advisory board;community collaboration;Community Healthcare;Conflict (Psychology);cost effective;Coupled;Data;Development;Doctor of Philosophy;early-career faculty;Education;Ensure;Equity;Evaluation;experience;Faculty;Foundations;Funding;Goals;Grant;Growth and Development function;Hand;Health;health care delivery;Health Policy;Healthcare;improved;Infrastructure;innovation;interest;International;Intervention;Knowledge;Lead;Leadership;lectures;Management Service Organizations;member;Mentors;Mission;multidisciplinary;New England;organizational structure;Phase;Pilot Projects;Policies;Preventive Medicine;Process;Productivity;program costs;Program Development;programs;Public Health;Publications;Research;Research Personnel;Science;sedentary lifestyle;Series;Services;Smoke;Structure;Students;success;symposium;Talents;Teacher Professional Development;United States National Institutes of Health;Universities;Vermont;Work;working group

PROJECT_TITLE: Core A: Administrative Core


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: This multidisciplinary Program Project Grant (PPG) assesses the role of accumulating pathologic transactive DNA/RNA binding protein ~43 kD (TDP-43) in frontotemporal degeneration (FTD) and amyotrophic lateral sclerosis (FTD-ALS) spectrum disorders and aging including limbic-predominant age-related TDP-43 encephalopathy (LATE) from the unique perspective of the breakdown of neural networks at molecular, microscopic and macroscale levels in humans, consistent with the highest priorities for FTD at the 2019 Alzheimer’s Disease and Related Disorders (ADRD) summit. In five novel, independent but synergistic Projects and five Cores that support each of the Projects, we hypothesize that our novel, well-integrated, network perspective will fill major gaps in knowledge by elucidating mechanistic insights into the pathophysiology of abnormal TDP-43 and the associated pattern of progressive disease, and offer fresh perspectives on the identification of accumulating TDP-43 pathology during life and its role in longitudinal clinical decline.

PI_NAMEs: IRWIN, DAVID JOHN;MCMILLAN, COREY T (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Adopted;Advisory Committees;age-related disease;Aging;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Animal Disease Models;Animal Model;Area;Autopsy;Biological Markers;Biometry;Brain;Brain region;Cell model;Cells;Clinical;Clinical Pathology;Collection;Complex;Dementia;Development;Diagnosis;Discipline;Disease;Disease Progression;DNA;Elements;emotion dysregulation;Ensure;Experimental Models;experimental study;Family;frontotemporal degeneration;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Genetic;Genetic Transcription;Goals;grasp;Heterogeneity;Human;human disease;Image;improved;in vivo;innovation;insight;Knowledge;language impairment;Lead;Life;limbic-predominant age-related TDP-43 encephalopathy;longitudinal course;Mediating;Microscopic;Molecular;motor disorder;multidisciplinary;Nerve Degeneration;Nervous System Physiology;neural;neural network;Neurons;novel;Outcome;Pathologic;Pathology;Pathway Analysis;Patients;Pattern;Persons;Prognosis;Program Research Project Grants;programs;Progressive Disease;Property;protein TDP-43;Resources;RNA-Binding Proteins;Role;Science;single-cell RNA sequencing;symposium;Syndrome;System;therapy development;tool;Translating;treatment trial;Work

PROJECT_TITLE: From cells to complex syndromes: using networks to understand heterogeneity in TDP-related frontotemporal degeneration and aging


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

PI_NAMEs: GROSSMAN, MURRAY  (contact)

PROJECT_TERMS: Advisory Committees;Aging;Alzheimer's Disease;career;Caregivers;Cells;Clinical;Clinical Research;cohort;Collaborations;Communities;Complex;connectome;Data;data sharing;Dementia;design;Diagnosis;Disease;DNA-Binding Proteins;doctoral student;Education and Outreach;effective therapy;Ensure;Event;Family;Fostering;frontotemporal degeneration;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Functional disorder;Funding;Genetic;Goals;graduate student;Growth;Heterogeneity;Human;human disease;improved;in vivo;Individual;insight;Institution;Interdisciplinary Study;International;Investigation;Knowledge;limbic-predominant age-related TDP-43 encephalopathy;meetings;Mentors;Mission;Monitor;multidisciplinary;Nerve Degeneration;neuroimaging;novel;Occupational activity of managing finances;Pathology;Patients;Pennsylvania;Persons;Policies;Postdoctoral Fellow;Prognosis;Program Research Project Grants;Program Reviews;programs;protein TDP-43;Reproducibility;Research;Research Personnel;Resource Sharing;Resources;Sampling;Scientific Advances and Accomplishments;Scientist;social media;symposium;Syndrome;Tauopathies;therapeutic development;Training;translational scientist;translational study;United States National Institutes of Health;Universities;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pain Research;Prevention;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Relevance Persistent post-surgical pain negatively impacts a large number of breast cancer survivors. There are currently no established interventions to help reduce the burden of this persistent post-surgical pain and its negative consequences. New interventions are needed to reduce suffering and improve the quality of life of breast cancer survivors with persistent post-surgical pain. This study tests a novel pain coping skills training intervention that was designed specifically for survivors with persistent pain after breast cancer surgery.

PI_NAMEs: BOVBJERG, DANA H.;SHELBY, REBECCA A (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: Acute;Address;Adoption;Affect;Anxiety;Automobile Driving;Award;Breast;Breast Cancer Patient;Breast Cancer survivor;breast lumpectomy;Cancer Center;cancer surgery;central sensitization;Clinic;Clinical;Clinical Trials Design;clinically significant;Coping Skills;curative treatments;design;Distress;Educational Intervention;effective intervention;efficacy evaluation;emotional distress;emotional functioning;Etiology;Excision;experience;Financial cost;follow-up;Health education;improved;Institution;Intervention;intervention cost;Malignant Breast Neoplasm;Malignant Neoplasms;Manuals;Mastectomy;Mediating;Mediator;Mental Depression;Newly Diagnosed;Nonpharmacologic Therapy;novel;Oncology;Operative Surgical Procedures;Pain;pain catastrophizing;Pain interference;pain reduction;pain sensitivity;Participant;Patients;Persistent pain;Pharmacological Treatment;Physical Function;pilot test;post intervention;Postoperative Pain;Prevalence;primary outcome;Process;psychobiologic;psychologic;Psychosocial Factor;Public Health;Quality of life;Randomized;randomized, clinical trials;Research;response;Role;secondary outcome;Self Efficacy;Sensory;Severities;Site;skills training;Survivors;Testing;Trauma;treatment as usual;Universities;Woman

PROJECT_TITLE: Persistent Post-Mastectomy Pain: Randomized Clinical Trial of Targeted Pain Coping Skills Training (Targeted-PCST) with Mediational Analysis

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: IRWIN, DAVID JOHN (contact)

PROJECT_TERMS: age related;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Amyotrophic Lateral Sclerosis;Autopsy;behavioral variant frontotemporal dementia;Biological Markers;biomarker identification;Biometry;Biostatistics Core;Blood;Blood specimen;C9ORF72;Cells;Cerebrospinal Fluid;Clinical;Clinical Markers;clinical phenotype;Clinical Trials;Collaborations;Complex;cost;Data;Databases;Dementia;design;Development;diagnosis standard;diagnostic accuracy;Disease;DNA;Encephalopathies;executive function;Family;Family member;frontotemporal degeneration;Frontotemporal Lobar Degenerations;Functional disorder;Genetic;Genetic study;Goals;Heterogeneity;Histopathology;human old age (65+);Image;Impairment;improved;in vivo;International;Investigation;Knowledge;Language;Life;Linguistics;Magnetic Resonance Imaging;Measures;Mediating;motor disorder;multimodality;mutation carrier;Natural History;Nerve Degeneration;neural network;Neurodegenerative Disorders;neuroimaging;neuropathology;Neuropsychology;Pathologic;Pathology;Patient imaging;Patient Recruitments;Patients;Persons;Phenotype;Primary Progressive Aphasia;Prognosis;Program Research Project Grants;protein TDP-43;rare condition;rare variant;recruit;Reproducibility;Research Personnel;Risk;RNA-Binding Proteins;screening;Semantics;Site;social;social deficits;Social Functioning;Standardization;Syndrome;tau Proteins;treatment response;treatment trial;Variant;Work

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Comparative Effectiveness Research;Contraception/Reproduction;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Rehabilitation;Rural Health;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health;Women's Health Research

PI_NAMEs: SIGMON, STACEY C (contact)

PROJECT_TERMS: addiction;Adherence;Area;Behavior;behavior change;Behavior Therapy;Behavioral;behavioral economics;behavioral health;Buprenorphine;Cardiac rehabilitation;Centers of Research Excellence;Cessation of life;Child;Chronic Disease;Clinical;clinical care;cognitive process;Consultations;Contraceptive Agents;cost effective;cost effectiveness;Cost Savings;cost utility analysis;Costs and Benefits;Decision Making;Dedications;design;Development;Diabetic Retinopathy;discounting;Doctor of Philosophy;Dose;drinking;Econometric Models;econometrics;economic impact;Economic Models;Electronic Nicotine Delivery Systems;Ensure;evidence base;Evidence based intervention;Evidence based treatment;executive function;financial incentive;Funding;Grant;Health;Health Personnel;High Risk Woman;improved;Individual;Individual Differences;individual variation;Insulin-Dependent Diabetes Mellitus;Interdisciplinary Study;International;Intervention;Knowledge;Myocardial Infarction;Nicotine;novel;opioid use disorder;Outcome;Participant;participant enrollment;Patients;perinatal women;Personal Behavior;Persons;pharmacologic;Phase;Pilot Projects;Post-Traumatic Stress Disorders;pregnant;Pregnant Women;premature;Research;Research Infrastructure;Research Personnel;response;Risk;Role;Rural;Rural Community;rural healthcare;Science;Scientific Advances and Accomplishments;screening;Services;Site;Smoker;Smoking;smoking cessation;Sudden infant death syndrome;Technical Expertise;Technology;telehealth;therapy design;treatment response;unintended pregnancy;Universities;university student;Vermont;Vulnerable Populations;Woman

PROJECT_TITLE: CORE B: Behavioral Economics and Intervention Science (BEIS) Core


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Autism;Brain Disorders;Fragile X Syndrome;Genetics;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Rare Diseases

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Maquat-lab research focuses on RNA metabolism in human health and disease. The lab's view is that understanding the molecular mechanisms of normal gene expression and what goes wrong with these mechanisms in disease are critical for the development of effective therapeutics. Disease states to be examined include fragile X syndrome, which is the most common single-gene cause of intellectual disability and autism, and a runaway innate immune response, which can lead to a cytokine storm in cases of bacterial or viral infections, including COVID-19.

PI_NAMEs: MAQUAT, LYNNE E (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Affect;autism spectrum disorder;Bacterial Infections;Binding;Biological Process;Biology;boys;Cardiomyopathies;Categories;Cell Nucleus;Cell Physiology;Cells;Complex;COVID-19;cytokine release syndrome;Cytoplasm;Development;Disease;Environment;Etiology;Exons;fascinate;Fragile X Syndrome;Frameshift Mutation;Gene Expression;Genes;Genetic;Genetic Transcription;girls;Goals;Health;Hereditary Disease;Human;human disease;Immune response;In Vitro;Inherited;Innate Immune Response;insight;Intellectual functioning disability;interest;Mammalian Cell;Mediating;Messenger RNA;Metabolism;Mitochondria;Molecular;mRNA Decay;mRNA Precursor;mRNA Translation;Mus;Muscle Fibers;Neuromuscular Diseases;Nonsense Codon;Nonsense Mutation;Nuclear;Outcome;Pathogenesis;Pharmacotherapy;prevent;Production;protein function;Proteins;Research;Research Personnel;RNA Cap-Binding Proteins;RNA metabolism;RNA Polymerase III;RNA Splicing;RNA-Binding Proteins;Role;Runaway;sarcopenia;therapeutically effective;Time;Transcription Coactivator Gene;Translations;Virus Diseases;Work

PROJECT_TITLE: Nonsense-mediated mRNA decay and beyond

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Malaria continues to be one of the largest public health concerns globally, yet an effective vaccine has not yet been realized. One reason is that the malaria parasite is far more complex than viruses or bacteria and has been evolving means to evade our immune system for millennia. Here, we propose a rethinking of malaria vaccine development using completely novel immune mechanisms that target novel parasite proteins with the goal of developing a highly protective vaccine capable of being used across highly diverse populations.

PI_NAMEs: JUNQUEIRA, CAROLINE ;WILDER, BRANDON KEITH (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Animal Model;Animals;Antibodies;Antigen Presentation;antigen processing;Antigen Targeting;Antigens;Bacteria;Binding;Biological Assay;Blood;CD8-Positive T-Lymphocytes;CD94 Antigen;cell killing;cell type;Cells;Cellular Structures;Complex;Cytomegalovirus;Data;Development;Disease;Epitopes;Erythrocytes;experimental study;Gene Modified;Genetic;Genetic Polymorphism;Goals;Haplotypes;Histones;HLA-A gene;Housekeeping;Human;Immune;Immune system;Immunity;Immunization;Immunize;immunogenicity;In Vitro;Individual;Infection;innovation;Knowledge;Ligands;Liver;Macaca mulatta;Major Histocompatibility Complex;Malaria;Malaria Vaccines;Mediating;Modeling;Monitor;nonhuman primate;novel;novel vaccines;Parasites;Peptides;Peripheral Blood Mononuclear Cell;Phenotype;Plasmodium;Plasmodium falciparum;Plasmodium vaccine;Plasmodium vivax;Plasmodium vivax vaccine;Play;Population Heterogeneity;Primary Infection;Primates;programs;Proteins;Public Health;rational design;Reagent;Relapse;response;Reticulocytes;Rhesus;Ribosomal Proteins;Role;Sampling;SIV;Source;Sporozoites;T cell response;T-Cell Receptor;T-Lymphocyte;Testing;Thinking;Transfection;Vaccination;vaccine candidate;Vaccine Design;vaccine development;vaccine efficacy;vaccine platform;Vaccine Research;vaccine strategy;Vaccines;Validation;vector;Virulent;Virus

PROJECT_TITLE: A universal malaria T cell vaccine based on HLA-E presentation

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]