ORG_DEPT: BIOLOGY

PHR: PROJECT NARRATIVE The dramatic increase in obesity and associated comorbidities presents a major public health concern with significant personal and societal consequences. Weight loss pharmacotherapies that target known food intake- inhibitory mechanisms (e.g., hindbrain and hypothalamic circuits) have been largely unsuccessful at promoting sustained weight loss. With this in mind, this proposal seeks to characterize a novel cerebellar satiation center and how activity in these neurons may prevent or reverse obesity.

PI_NAMEs: BETLEY, JOHN NICHOLAS (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Acute;Affect;Afferent Neurons;Anterior;Attenuated;Body Weight decreased;Brain;brain pathway;Cell Nucleus;Cerebellar Nuclei;Cerebellum;Chemicals;Chronic;comorbidity;Cues;Data;Development;Diet;diet-induced obesity;Eating;Energy Intake;Energy Metabolism;experimental study;feeding;Feeding behaviors;Food;Generations;Glutamates;Goals;gut-brain axis;Health;hindbrain;human subject;Hyperphagia;Hypothalamic structure;Lateral;Lesion;loss of function;Metabolism;Monitor;Motor output;Mus;neural;Neurons;neurotransmission;novel;Nutrient;Obesity;obesity development;obesity prevention;obesity treatment;Operative Surgical Procedures;Pathway interactions;Pharmacotherapy;Physiological;Population;pre-clinical assessment;Prevalence;prevent;Public Health;Regulation;Research;response;Satiation;Sensory;Signal Pathway;Signal Transduction;Smell Perception;Synapses;Taste Perception;Testing;Therapeutic;therapeutic target;tool;translational approach;Vagus nerve structure;Viral;Vision;Weight Gain

PROJECT_TITLE: Regulation of satiation centers in health and obesity

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Neuropathy is a major public health concern, characterized by pain, falls, and amputations, and is underdiagnosed in Black and low-income patients in Flint, Michigan. Without appropriate diagnosis, physicians cannot manage neuropathy risk factors or pain in patients with neuropathy. In our planned research, we aim to determine the size of gaps in neuropathy diagnosis and management in a predominantly Black, low-income patient population and adapt an intervention targeting reasons for these gaps, advancing the mission of the NIH to address health disparities, reduce disability, and improve quality of life.

PI_NAMEs: ELAFROS, MELISSA  (contact)

PROGRAM_OFFICER_NAME: SYPEK, ELIZABETH IRENE

PROJECT_TERMS: Address;Adoption;Adult;Affect;American;Amputation;Analgesics;Attitude;Black American;black patient;Black race;career;Caring;Characteristics;Clinic;Clinical;Clinical Decision Support Systems;clinical efficacy;Cluster randomized trial;computerized;Computerized Medical Record;Data;Decision Making;Diabetes Mellitus;Diagnosis;Diagnostic;disability;Disabling condition;Disease Progression;electronic medical record tool;evidence base;evidence based guidelines;Evidence based intervention;falls;Foundations;Future;Goals;Guidelines;Health;health disparity;Health system;Hyperglycemia;implementation science;improved;Individual;innovation;Intervention;Intervention Trial;Interview;Knowledge;Low income;Low Income Population;Mentorship;Metabolic;Metabolic syndrome;Methods;Michigan;Mission;modifiable risk;Modification;Morbidity - disease rate;Neuropathy;Obesity;Outcome;Pain;Pain management;painful neuropathy;patient population;Patients;Physicians;Pilot Projects;pilot test;Play;Population;Poverty;Practice Management;Prevalence;primary care clinic;Primary Care Physician;primary care provider;Public Health;Quality of life;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Research Design;Risk Factors;Risk Management;Role;screening;skills;Structure;Surveys;Symptoms;Testing;Theoretical Domains framework;Training;Underserved Population;United States National Institutes of Health

PROJECT_TITLE: The Flint Neuropathy Study: assessing diagnostic and management gaps in a Black, low-income population

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Precision Medicine

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Individuals with Parkinson disease (PD) often develop a combination of motor, cognitive, and psychiatric problems that adds substantial morbidity, mortality and economic burden to patients, families and society. The variability in clinical manifestations across individuals reflects different PD subtypes. This study will compare clinical progression and biological measures across subtypes, thus yielding methods for patient stratification, targets for treatment intervention, and the ability to predict PD progression.

PI_NAMEs: CAMPBELL, MEGHAN C (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Abbreviations;alpha synuclein;Amyloid beta-Protein;Atrophic;Autonomic Dysfunction;Autopsy;Behavior assessment;Behavioral;Biological;Biological Markers;Brain;Brain Pathology;cholinergic;Classification;Clinical;clinical application;Clinical assessments;Clinical Data;clinical movement disorder;clinical subtypes;clinically relevant;Cognition;Cognitive;cognitive function;cohort;Corpus striatum structure;Data;Data Set;Dementia;dementia risk;Deposition;Development;Disease Progression;disorder subtype;Economic Burden;Evaluation;falls;Family;Freezing;Functional disorder;Functional Magnetic Resonance Imaging;Gait;Gait abnormality;Hallucinations;Impaired cognition;improved;Individual;Intervention;Longitudinal cohort;Magnetic Resonance Imaging;Measures;Medical Records;Methods;Midbrain structure;Morbidity - disease rate;mortality;Motor;motor deficit;motor impairment;Movement Disorders;multimodal neuroimaging;multimodality;Neurobiology;Neurodegenerative Disorders;Neurotransmitters;non-motor symptom;noradrenaline transporter;noradrenergic;novel;Orthostasis;Outcome;Outcome Study;Parkinson Disease;Participant;Pathology;patient health information;Patient Selection;patient stratification;Patients;Pattern;personalized intervention;personalized medicine;Positron-Emission Tomography;prevent;prognostic value;Proteins;psychiatric symptom;Research;screening;Severity of illness;Societies;Statistical Models;Subgroup;System;tau Proteins;Testing;Time;tool;Tracer;Translating;Validation

PROJECT_TITLE: Parkinson Disease Clinical Subtypes: Validation, Clinical Utility, and Biological Correlates

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Nutrition;Obesity

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative  Over the past two decades there has been a dramatic increase in the prevalence of inflammatory bowel disease, coincident with the obesity epidemic. One way to combat this problem is to understand more about how the expansion of fat tissue in the abdomen mediates inflammation of the gastrointestinal tract. The goal of this study is to understand how intra-abdominal fat tissue inflammation affects the gastrointestinal system and identify new approaches to alleviate inflammatory bowel disease.

PI_NAMEs: GLINIAK, CHRISTY M (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Abdomen;abdominal fat;Adipocytes;adipokines;Adipose tissue;Affect;Animals;Anti-Inflammatory Agents;Area;Bacteria;Biological Markers;Biology;blood glucose regulation;burden of illness;Cell Nucleus;cell type;Cells;Characteristics;chemokine;Chronic;Clinical;Clinical Data;combat;Communication;Complex;coping;Crohn's disease;cytokine;Data;diet-induced obesity;Disease;Disease Progression;Endocrine Glands;Exposure to;Fatty acid glycerol esters;feeding;gastrointestinal;gastrointestinal system;Gastrointestinal tract structure;Gene Expression;Goals;gut inflammation;Heterogeneity;High Fat Diet;Hormones;Human;Hyperplasia;Hypertrophy;Ileocolitis;Immune;immune cell infiltrate;Immune response;Immune system;immunoregulation;improved;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Bowel Diseases;Intestines;Intra-abdominal;Knowledge;Large Intestine;Link;lipid biosynthesis;lipid metabolism;Lipids;Literature;Liver;lymph nodes;Lymphatic;Mediating;Mesenteric Arteries;Mesentery;Metabolic;Metabolic Diseases;Methods;Modeling;mouse model;Mus;Nature;Nerve;novel strategies;Obesity;Obesity Epidemic;Organ;Outcome;Overnutrition;Pathologic;Physiological Processes;Physiology;Population;Prevalence;progenitor;Property;Research;response;Role;Serous Membrane;Severities;Sex Differences;sexual dimorphism;single-cell RNA sequencing;Small Intestines;stem cell differentiation;stem cells;Study models;Techniques;Therapeutic;therapeutic target;therapy outcome;Tissue Expansion;Tissues;transcriptome sequencing;Translating;Ulcerative Colitis;Veins;Visceral;Visceral fat;Work

PROJECT_TITLE: Interaction of Mesenteric Adipose Tissue Physiology, Expansion, and Inflammation with Inflammatory Bowel Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Dental, Oral, and Craniofacial Disease;Lymphatic Research;Microbiome;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: TAMPA

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative Many aspects of age-related cognitive decline, Alzheimer’s disease (AD), and its related dementia (ADRD) start several years before the full symptoms are diagnosed, however, markers to early predict them are limited. Here, we aim to establish saliva-based protein, microbiome, and inflammatory biomarkers diagnosing and predicting the progression of age-related cognitive decline and ADRD- debilitating, costly, and non-curable public health problems in older adults. The outcomes of this study will establish proof-of-concept that can be validated in large clinical studies, fulfilling the R21 application objective and perfectly aligning with the goals of NIA’s PAR-22-094.

PI_NAMEs: JAIN, SHALINI  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Age;Age-associated memory impairment;Aging;aging related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid beta-Protein;Biological Markers;biomarker panel;Blood;Brain;brain circulation;Brain imaging;breast cancer metastasis;Cancer Detection;Cells;Cerebrospinal Fluid;chemokine;Circulation;Clinical;clinical diagnosis;Clinical Research;Clinical Trials;Cognition;Cognitive;cohort;Cohort Studies;cost;cytokine;Data;Databases;Dementia;Detection;Development;Diagnosis;Disease;early detection biomarkers;Early Diagnosis;early onset;family burden;Florida;follow-up;Follow-Up Studies;Foundations;Frequencies;Funding;Goals;Head and neck structure;Healthcare Systems;high risk;Image;Impaired cognition;Individual;Inflammation;Inflammatory;inflammatory marker;Interleukin-1 beta;Interleukin-6;Knowledge;Link;Lymphatic;lymphatic circulation;Lymphatic System;macromolecule;Magnetic Resonance Imaging;Measurement;Measures;Memory Loss;microbial;microbial community;microbiome;mild cognitive impairment;minimally invasive;Monitor;Mucous Membrane;National Institute on Aging;older adult;Oral;Oral cavity;Oral health;oral microbiome;Outcome Measure;Outcome Study;Participant;Patients;Peptides;Periodontitis;Plasma;Population;Positron-Emission Tomography;predictive marker;Prevalence;Prevention;Prognosis;Prognostic Marker;prospective;protein biomarkers;Proteins;proteomic signature;Proteomics;Public Health;Publishing;recruit;Research;Resources;Retrospective Studies;Risk;risk prediction;Saliva;saliva proteome;Salivary;Sampling;Societies;Symptoms;System;systemic inflammatory response;tau Proteins;tau-1;Testing;TNF gene;Training;United States Food and Drug Administration

PROJECT_TITLE: Saliva based protein markers for predicting the risk of cognitive decline and dementia in older adults.

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Epilepsy;Mental Health;Neurodegenerative;Neurosciences;Rehabilitation;Sleep Research

ORG_CITY: MADISON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Defining neural signatures of distinct states of arousal and awareness is key to understanding the neural basis of consciousness. This proposal seeks to understand these mechanisms using intracranial electrophysiological recordings from human patients who undergo clinical evaluation for surgical remediation of their medically intractable epilepsy. Knowledge gained from this project will be of high impact for improvements in monitoring depth of anesthesia, and in the diagnosis, management and prognosis of pathological states of consciousness including central sleep disorders, delirium, vegetative or minimally conscious states, and coma.

PI_NAMEs: BANKS, MATTHEW I (contact);NOURSKI, KIRILL V

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Acute Disease;Algorithms;Anesthesia procedures;Arousal;Attention;Auditory;awake;Awareness;Back;Behavioral;Biological Assay;Biological Markers;biomarker identification;Brain;Brain region;Clinical;clinically relevant;Coma;Computer Models;Conscious;Conscious Sedation;Consciousness Disorders;Data;Delirium;Development;Diagnosis;Dreams;Drowsiness;Drug Kinetics;Electric Stimulation;Electroencephalography;Electrophysiology (science);Environment;Epilepsy;executive function;Exhibits;experimental study;Functional Magnetic Resonance Imaging;General Anesthesia;Human;human subject;Impaired cognition;Impairment;improved;innovation;Intractable Epilepsy;Knowledge;Magnetic Resonance Imaging;Medical;Memory;Minimally Conscious States;Modeling;Monitor;multimodality;network models;neural;neural correlate;neurosurgery;novel;Operative Surgical Procedures;Outcome;Pathologic;Patients;Pattern;Perception;Perceptual disturbance;Postoperative Period;potential biomarker;Probability;Process;Production;Prognosis;Recovery;remediation;Reporting;research clinical testing;Resolution;response;Rest;Scalp structure;Secondary to;Sedation procedure;Seizures;Sensory;Sleep;Sleep Disorders;Sleep Stages;sound;specific biomarkers;Speech;Speech Perception;Stimulus;Structure;symptomatology;Symptoms;Testing;Unconscious State;Work

PROJECT_TITLE: Mechanisms of Loss, Recovery and Disorders of Consciousness


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Alzheimer’s disease is characterized by both the progressive, abnormal accumulation of amyloid- and tau protein aggregates and the selective vulnerability of different brain regions and cell types to disease spread. We will apply multiomics to newly generated humanized mouse models of AD, which model the interactions between amyloid- and tau, to decipher cell-type-specific vulnerabilities and cell-cell interactions in relation to A and tau proteinopathies, from mice characterized by electroencephalographic recordings and machine learning-analyzed behavior. We integrate multiomics and functional data and compare mouse with previously-generated human multiomics data to evaluate the relevance of our findings to the human condition.

PI_NAMEs: COBOS, INMA  (contact);PALOP, JORGE J

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: abeta accumulation;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amygdaloid structure;Amyloid;Amyloid beta-Protein;Astrocytes;ATAC-seq;Axon;Bar Codes;Behavior;Behavioral;behavioral phenotyping;behavioral study;Brain;brain cell;Brain region;Cell Communication;Cell Nucleus;cell type;Cells;Cessation of life;Chronic;Cognitive deficits;Custom;Data;Data Set;Dimensions;Disease;Disease Progression;Early identification;Electroencephalography;Electrophysiology (science);epigenome;epigenomics;familial Alzheimer disease;Genes;Genetic Transcription;Goals;Haplotypes;Heterogeneity;Hippocampus;Human;human data;human disease;humanized mouse;Impairment;in vivo;Inflammation;Interneurons;Knock-in;Knock-in Mouse;Limbic System;Machine Learning;Maps;Methods;Microglia;Modeling;Molecular;Morphology;Motor Cortex;mouse model;Multiomic Data;multiple omics;Mus;Mutation;nano-string;Neocortex;neocortical;Nerve Degeneration;network dysfunction;neurofibrillary tangle formation;neuronal cell body;Neurons;novel;Oligodendroglia;optogenetics;Pathogenicity;Pathology;Physiology;Population;Predisposition;Prefrontal Cortex;presynaptic;progressive neurodegeneration;Property;protein aggregation;protein expression;Proteomics;Proto-Oncogene Protein c-kit;Receptor Protein-Tyrosine Kinases;Research;Resistance;Resolution;response;Senile Plaques;Sex Differences;single cell ATAC-seq;single-cell RNA sequencing;Somatosensory Cortex;Synapses;tau aggregation;tau Proteins;Tauopathies;Testing;transcriptome;transcriptomics;Visual Cortex;Work

PROJECT_TITLE: Multidimensional mapping of vulnerable cell types in humanized Alzheimer's disease mouse models


ADMINISTERING_IC: ES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Pediatric

ORG_CITY: CINCINNATI

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE / RELEVANCE There has been an increasing national awareness of the rising number of environmentally-related diseases such as diabetes, obesity, asthma, neurodevelopmental disorders, and prematurity, among others. The Molecular Epidemiology in Children's Environmental Health (MECEH) Training Program fills a critical need in public health by providing future researchers and clinicians with multidisciplinary knowledge and training in leading and cutting-edge methodologies in the area of pediatric environmental health.

PI_NAMEs: BRUNST, KELLY J (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Child;Environmental Health;Molecular Epidemiology;Training Programs

PROJECT_TITLE: Molecular Epidemiology in Children's Environmental Health Training Program (MECEH)


NIH_SPENDING_CATS: Behavioral and Social Science;Diabetes;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: AMERICAN PSYCHOLOGICAL ASSOCIATION

ORG_STATE: DC

PHR: PROJECT NARRATIVE The Leadership and Educational Advancement Program (LEAP) for Diverse Scholars is an evidence- informed mentoring and leadership development program for early career social and behavioral scientists from underrepresented racial and ethnic populations who show promise in research related to the National Institutes on Diabetes Digestive and Kidney Disorders (NIDDK) mission but who have not yet received R01 funding and have not ascended to a leadership position in their respective disciplines or professional associations. A longer-term goal of the project is to help diversify the scientific workforce in order to improve research innovation and opportunities for diverse research teams to collaborate on research in the NIDDK-mission areas and enhance health, lengthen life, and reduce illness and disability particularly in underserved populations.

PI_NAMEs: BUTLER, ASHLEY M;HASKINS, JANICE  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Acceleration;Address;American Psychological Association;Area;Behavioral;behavioral and social science;Behavioral Research;Behavioral Sciences;Biological;burden of illness;career;Career Choice;career development;Clinical;cohort;Collaborations;Complex;course development;Creativeness;Development;Diabetes Mellitus;Digestive System Disorders;disability;Discipline;Dissemination and Implementation;Education;education research;Endocrine;Endocrine System Diseases;Ensure;Environmental Risk Factor;equity, diversity, and inclusion;ethnic diversity;ethnic minority;ethnic minority population;Ethnic Origin;Ethnic Population;Evaluation;experience;Foundations;Funding;Funding Mechanisms;Goals;Health;health care settings;health disparity populations;health outcome disparity;Hematological Disease;Hybrids;implementation research;improved;Individual;innovation;Interdisciplinary Study;interest;Intervention;Kidney Diseases;Leadership;leadership development;Life;lifestyle factors;low socioeconomic status;Maintenance;Medicine;Mentors;Mentorship;Metabolic Diseases;Mind;Mission;Nutrition Disorders;Obesity;Outcome;Participant;Patients;Persons;population health;Positioning Attribute;Postdoctoral Fellow;Prevalence;prevent;Prevention strategy;Professional Organizations;Program Development;programs;Psychological Factors;Race;racial minority;racial minority population;racial population;recruit;Research;Research Personnel;Research Proposals;Role;Scholars Program;Science;Scientist;skill acquisition;skills;social;social factors;Strategic Planning;success;Training;Translating;treatment strategy;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Urologic Diseases;virtual;Vocational Guidance;volunteer

PROJECT_TITLE: Research Leadership Development Program for Diverse Early Career Scientists


NIH_SPENDING_CATS: Genetics

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The overarching mission of our research is to decipher the epigenetic and transcriptional mechanisms that regulate cell lineage specification. These processes are frequently dysregulated in cancer. We focus on the biology of the TET family of DNA dioxygenases, key proteins that are frequently altered in hematologic malignancies and are involved in lineage specification.

PI_NAMEs: TSANGARATOU, AGELIKI  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;Affect;Binding;Binding Sites;Biochemical;Biology;Catalytic Domain;Cell Lineage;Cell Maturation;Cell Proliferation;cell type;Cells;Characteristics;Chromatin;Cytosine;Development;Dioxygenases;Disease;DNA;DNA Methylation;Ensure;Epigenetic Process;epigenetic regulation;Excision;Family;Family member;Gene Expression;Gene Expression Profile;Genetic;Genetic Transcription;Genome;Genomics;Hematologic Neoplasms;histone modification;Human;Learning;Malignant Neoplasms;Mediating;Methylation;Mission;Organism;precursor cell;Process;programs;Protein Family;protein function;Protein translocation;Proteins;recruit;Research;Role;Specific qualifier value;stem cells;Syndrome;transcription factor;Transcriptional Regulation;Work

PROJECT_TITLE: Epigenetic Regulation of Lineage Specification

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: GREENSBORO

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NORTH CAROLINA AGRI & TECH ST UNIV

PHR: Project Narrative We will conduct a mixed-methods study to explore the impact of a neonatal intensive care unit (NICU) design change from open bay to single family rooms at Cone Health. We will triangulate patient health outcome data, patient experience surveys, and in-depth interviews with NICU staff to identify disparities in health outcomes and experience of care and unearth rich details on processes and mechanisms that reproduce health disparities. In partnership with community stakeholders, we will develop a conceptual framework and disseminate lessons learned and actionable recommendations to drive change at Cone Health and other health systems to improve quality and delivery of health care, improve health outcomes, and reduce health disparities.

PI_NAMEs: TEIXEIRA-POIT, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Admission activity;African American student;Anecdotes;Area;Attention;Black race;care delivery;Caring;Child Health;Communities;community engaged approach;Cone;Data;Data Analyses;Data Collection;Decision Making;design;Development;Disadvantaged;disparity reduction;Economics;Ensure;Environment;Ethnic Origin;Evaluation;experience;Family;Frequencies;graduate school;Health;health care delivery;health disparity;Health system;Historically Black Colleges and Universities;improved;Inequality;Interview;job market;Latinx;Learning;Lighting;Literature;Low income;Maternal and Child Health;Medical;Methods;Mothers;Needs Assessment;Neonatal Intensive Care Units;neonate;Newborn Infant;Noise;Nurses;Outcome;Parents;Patient Care Team;patient subsets;Patients;Perception;Policies;Premature Birth;Procedures;Process;professional students;Quality of Care;Race;racial disparity;Recommendation;Reduce health disparities;Research;Review Literature;Safety;Sensory Deprivation;skills;social health determinants;Socioeconomic Status;Structure;Students;Surveys;Time;Transportation;trend;Woman;Workload

PROJECT_TITLE: Identifying and Mitigating Health Disparities Following a Neonatal Intensive Care Unit (NICU) Design Change from Open Bay to Single Family Rooms


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

PHR: Project Narrative / Public Health Relevance Statement: Cervical cancer is a major global health problem. Globally, 570,000 new cases of cervical cancer occur annually, resulting in 311,000 deaths, nearly 90% of which occur in low- and middle-income countries (LMICs). There is a critical need for a sensitive and specific Screen-Diagnose-Treat strategy that can be performed in a single visit in LMICs as well as low-resource settings in the US to reduce the morbidity and mortality of this disease.

PI_NAMEs: RICHARDS-KORTUM, REBECCA R. (contact);SCHMELER, KATHLEEN

PROGRAM_OFFICER_NAME: SAHASRABUDDHE, VIKRANT V

PROJECT_TERMS: Ablation;accurate diagnosis;Acetic Acids;Algorithmic Analysis;Algorithms;Area;automated algorithm;automated image analysis;automated visual evaluation;Biomedical Engineering;Biopsy;Brazil;Cancer Center;cancer epidemiology;Cancer Etiology;Cancer Hospital;cancer prevention;cancer therapy;Cellular Phone;Cervical;cervical biopsy;cervical cancer prevention;Cervical Cancer Screening;Cervical Intraepithelial Neoplasia;Cervix Uteri;Cessation of life;Clinical;Clinical Research;Cold Therapy;Collaborations;college;Colposcopes;Colposcopy;confocal imaging;cost;Country;Cytology;Detection;Devices;Diagnosis;Diagnostic;diagnostic tool;digital;Disease;Equipment;Excision;experience;Fiber Optics;follow-up;global health;Health Sciences;high resolution imaging;Hospitals;HPV screening;HPV-High Risk;Human Papillomavirus;Human Resources;Image;Image Analysis;image archival system;imaging capabilities;imaging modality;imaging probe;Imaging technology;improved;Incidence;industry partner;Infrastructure;innovation;Institution;Instruction;Lead;Lesion;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medical;Medical Imaging;Medically Underserved Area;Medicine;microendoscope;microscopic imaging;Modality;Modeling;Morbidity - disease rate;morphometry;mortality;Multimodal Imaging;multimodality;Nuclear;Nuclear Atypia;overtreatment;Pathology;Patients;Performance;point of care;premalignant;Prevention program;programs;prospective;Provider;public health relevance;Research Personnel;Resolution;Resource-limited setting;Resources;Rice;screening;screening program;Sensitivity and Specificity;Services;Site;Specificity;standard of care;Testing;Thermal Ablation Therapy;Time;Training;treatment program;United States;Universities;University of Texas M D Anderson Cancer Center;usability;Visit;Visual;Woman;women's diagnosis;Women's mortality;women's treatment;World Health Organization

PROJECT_TITLE: Low-cost mobile colposcopy and confocal imaging for global prevention of cervical cancer


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Stroke

PHR: Project Narrative: Aneurysmal subarachnoid hemorrhage (SAH) carries very significant mortality and morbidity, with nearly half of SAH survivors having major cognitive dysfunction that impairs their functional status, emotional health, and quality of life. Much of this is due to Delayed Cerebral Ischemia (DCI) and the present study aims to understand the underlying mechanisms of anesthetic conditioning-induced protection against DCI. Through the proposed experiments, it is likely that new pathophysiologic mechanisms will be determined and new therapeutic targets identified that may ultimately lead to improved patient outcome after SAH.

PI_NAMEs: ATHIRAMAN, UMESHKUMAR  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acute;Anesthesiology;Anesthetics;Aneurysmal Subarachnoid Hemorrhages;Angiography;Animal Model;Arteries;Attenuated;Automobile Driving;B-Cell Activation;Behavioral;Biochemical;Biological;Brain;Brain hemorrhage;Brain Injuries;Cerebral Ischemia;Clinical Trials;combat;conditioning;Data;Development;Distal;Down-Regulation;Elements;Emotional;Enhancers;Environment;experience;experimental study;Failure;Functional disorder;functional outcomes;functional status;Funding;Genetic;genomic tools;Goals;halogenation;Health;Hemorrhage;I-kappa B Proteins;Image;Immunohistochemistry;Impaired cognition;Impairment;improved;improved outcome;in vivo;inducible gene expression;Inflammation;innovation;insight;Intervention;Isoflurane;Knowledge;Light;Mediating;member;Mentorship;Methods;Microglia;Molecular;Molecular Biology Techniques;Molecular Target;Morbidity - disease rate;mortality;mouse model;Mus;neurobehavioral;Neurologic Deficit;neurosurgery;neurovascular;new therapeutic target;NF-kappa B;Nitric Oxide Synthetase Inhibitor;NOS2A gene;novel;novel therapeutic intervention;Nuclear;optical imaging;Optics;Outcome;Outcome Assessment;overexpression;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Physicians;Pilot Projects;Play;preclinical study;Preclinical Testing;prevent;Process;protective effect;protein expression;pyrrolidine dithiocarbamate;Quality of life;Research Personnel;Rodent Model;Role;Scientist;Severities;Signal Transduction;skills;Source;Subarachnoid Hemorrhage;Survivors;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;Thrombosis;Thrombus;tool;Training;transcription factor;Translating;translational potential;Universities;Vasospasm;Volatilization;Washington;Work

PROJECT_TITLE: Molecular mechanisms underlying isoflurane conditioning-induced neurovascular protection in subarachnoid hemorrhage


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Transplantation

ORG_CITY: BIRMINGHAM

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: This project will utilize the first model of ocular hypertension (elevated IOP) in the living eyes of research- consented brain-dead organ donors prior to organ procurement. This innovative model enables the analysis of the tissue and cellular responses to changes in IOP within the human optic nerve head and will uncover the cellular pathways involved in glaucoma, establishing novel therapeutic targets and strategies.

PI_NAMEs: FAZIO, MASSIMO ANTONIO;GIRKIN, CHRISTOPHER ANTHONY (contact);GROSS, ALECIA K

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Acute;Animal Model;Animals;Astrocytes;axon injury;Biomechanics;Blindness;Blood Vessels;Brain Death;cell type;Cells;clinical care;clinical imaging;Connective Tissue;Consent;Data;density;design;Development;Electrophysiology (science);Evaluation;Exhibits;experimental study;Eye;Fibroblasts;Functional disorder;Glaucoma;Histopathology;Human;human disease;imaging approach;Immunohistochemistry;in vivo;Individual;Inflammatory;Injury;innovation;insight;Ischemia;Link;Measurement;Measures;Mechanics;mechanotransduction;Methods;Microglia;Modeling;Molecular;neural;Neuroglia;new therapeutic target;novel therapeutics;Ocular Hypertension;Optic Disk;Optic Nerve;optic nerve disorder;Organ Donor;Organ Procurements;Papillary;Pathologic;Pathway interactions;Perfusion;Phenotype;Physiologic Intraocular Pressure;Predisposition;pressure;promote resilience;Protein Analysis;Proteins;Research;Resources;response;Retina;retinal axon;Retinal Ganglion Cells;Risk;Risk Factors;Science;Sclera;Stress;Stretching;Structure;Study models;targeted treatment;Testing;therapeutic development;Therapeutic Intervention;Time;tissue culture;Tissues;Transcript;transcriptome;transcriptomics;Translations;Variant;Weight-Bearing state

PROJECT_TITLE: The mechanotranscriptome of the optic nerve head following acute experimental ocular hypertension in living human eyes

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Transplantation;Tuberculosis;Vaccine Related

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Abstract Tuberculosis (TB) kills around 1.5 million people each year and is a major cause of mortality from a single infectious disease worldwide. Emergence of multidrug-resistant TB (MDR-TB) is now a bigger problem in more than 60 countries of the world. MDR-TB not responsive to standard anti- tuberculosis drugs, very difficult to control and as a consequence, shows a high mortality. During the recent years, efforts have been made to strengthen the immune responses in these patients to control tuberculosis organisms. We discovered that human mesenchymal stem cells can strengthen immune cells against tuberculosis. In this proposal, we will develop an innovative and more effective combination of mesenchymal stem cells and an anti-tuberculosis drug to control MDR tuberculosis.

PI_NAMEs: ENDSLEY, JANICE J;JAGANNATH, CHINNASWAMY  (contact)

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Acid Fast Bacillae Staining Method;Anti-Inflammatory Agents;Antigen Presentation Pathway;Antimycobacterial Agents;Antitubercular Agents;Attenuated;Autoimmune;Autoimmune Diseases;autoimmune inflammation;Autologous;Autophagocytosis;Bacillus;Bacteria;bactericide;BCG Vaccine;Bone Marrow;Bone Marrow Aspiration;Cancer Control;Cell Transplantation;Cells;cellular engineering;Characteristics;chemokine;Clinical;Clinical Trials;Coculture Techniques;Collection;Communicable Diseases;Country;cytokine;Disease;DNA;Epigenetic Process;Extreme drug resistant tuberculosis;Gene Cluster;Gene Expression;Genes;Granuloma;Growth;Health;Hematopoietic stem cells;Human;Immune;immune function;Immune response;Immune system;immunogenicity;immunological status;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Infiltration;Inflammatory;Infusion procedures;innovation;Interferon Type II;Interleukin-10;Interleukin-4;Intervention;Lung;lung repair;lymph nodes;Lysosomes;Macrophage;Macrophage Activation;Malignant Neoplasms;Mediating;Mesenchymal Stem Cells;Methods;Modeling;Molecular;mortality;Multidrug-Resistant Tuberculosis;Mus;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;neutrophil;Nitric Oxide;novel;Organism;Pathology;Patients;Persons;Phagocytes;Phagosomes;Pharmaceutical Preparations;phase 1 study;phase I trial;Phenotype;Preventive vaccine;programs;prophylactic;pulmonary function;pulmonary granuloma;Pulmonary Tuberculosis;recruit;Regimen;repaired;response;Sirolimus;Spleen;stem cell therapy;stem cells;Stromal Cells;T-Lymphocyte;Therapeutic;therapeutic vaccine;transcriptome;transcriptome sequencing;Transfusion;Tuberculosis;tuberculosis drugs;tuberculosis granuloma;tuberculosis immunity;Up-Regulation;Vaccine Therapy;Vaccines;Validation

PROJECT_TITLE: Novel Stem Cell Immunotherapy for MDR-Tuberculosis


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Inflammatory bowel diseases (IBD) are a group of heritable, chronic disorders of the gastrointestinal tract affecting more than 3 million people in the U.S. with a direct healthcare cost of $6.3 billion/year. The pathogenesis of IBD is poorly understood though genetic factors are known to strongly influence the IBD risk. This proposal will identify novel putative causal variants for IBD through harmonizing and fine-mapping large-scale genomic resources across multiple ancestries, and characterize their molecular and cellular impacts through targeted genome perturbations and knockins in human T cells.

PI_NAMEs: HUANG, HAILIANG  (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Address;Adolescence;Affect;African;Algorithms;American;Autoimmune Diseases;Binding Sites;Biological;Biology;causal variant;Cells;Chromosome Mapping;Chronic;Chronic Disease;Code;cohort;CRISPR interference;CRISPR-mediated transcriptional activation;Data;data harmonization;Data Set;design;Digestive System Disorders;disorder risk;East Asian;emerging adult;Ensure;European;European ancestry;exome sequencing;experimental study;Gene Expression Regulation;Gene Frequency;Gene Targeting;Genetic;genetic association;Genetic Diseases;Genetic study;genetic technology;genetic variant;Genome;genome resource;genome wide association study;genomic data;genomic locus;Genomic Segment;Genomics;Genotype;genotyping technology;Goals;Health Care Costs;health disparity;Heritability;Heterogeneity;Histones;Human;Human Genetics;improved;in silico;Individual;Inflammatory Bowel Diseases;insight;International;Knock-in;Knowledge;Link;Linkage Disequilibrium;Maps;Meta-Analysis;Methodology;Methods;Molecular;Nature;novel;Outcome;Pathogenesis;Pathway interactions;Persons;pleiotropism;Population;Printing;Probability;Process;protein function;Quality Control;Resolution;Resources;Rest;Sample Size;Sampling;Series;Site;success;T-Lymphocyte;Technology;Testing;Therapeutic;Tissues;transcription factor;Uncertainty;United States National Institutes of Health;Untranslated RNA;Variant;web portal

PROJECT_TITLE: Identification and characterization of inflammatory bowel disease causal variants

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW YORK

ORG_DEPT: CHEMISTRY

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Computational modulator design and machine learning to target protein-protein interactions Protein-protein interactions (PPIs) are functionally involved in every cellular signaling pathway. The artificial modulation of PPIs represents a challenging but very promising direction in drug discovery. Here we aim to develop new computational tools, state-of-the-art machine learning models and innovative design strategies to overcome current limitations in computational aided drug design, and discover highly specific and potent modulators of a variety of medically important biomolecular interactions as tools for studying biological functions, as well as new leads for therapeutic development.

PI_NAMEs: ZHANG, YINGKAI  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Affinity;alpha helix;Area;Binding;Biological;Biological Process;Biology;Biophysics;Cell Death Induction;chemical reaction;Chemicals;Collaborations;computerized tools;deep learning model;design;Disease;Docking;Drug Design;drug development;drug discovery;Drug Targeting;EP300 gene;frontier;Goals;Graph;Hydrogen Bonding;improved;inhibitor;innovation;insight;laboratory experiment;Lead;Learning;Length;Life;Ligands;Machine Learning;machine learning model;MDM2 gene;Medical;Methods;mimetics;Molecular;molecular modeling;Nature;novel;Pathway interactions;programs;Property;protein function;protein protein interaction;Proteins;rational design;Regulation;Research;Signal Pathway;Signal Transduction;small molecule;success;Surface;Tertiary Protein Structure;Testing;therapeutic development;Therapeutic Intervention;therapeutic target;Therapeutic Uses;tool;unnatural amino acids;virtual screening;Virus


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: NARRATIVE The coagulopathy and inflammation of sepsis are major causes of human disability and death with a higher incidence worldwide than that of cancer. Death as an outcome averages 30%, underscoring the incomplete knowledge of the molecular pathogenesis of sepsis needed for breakthroughs to address this escalating health problem. This research program leverages the expertise of a successful team of scientists and clinicians whom propose to continue generating transformational discoveries of mechanisms underlying sepsis with the potential to further stratify this disease process while identifying more effective diagnoses and treatments.

PI_NAMEs: MARTH, JAMEY  (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Address;Age;Alkaline Phosphatase;Biological Markers;biomedical scientist;Blood;Blood Coagulation Disorders;Blood Coagulation Factor;Blood Platelets;Blood Vessels;Cause of Death;Cell surface;Cessation of life;Clinical;comparative;Core Facility;Data;data acquisition;Data Analyses;Development;Diagnosis;Diagnostic;disability;Disease;Disease Marker;disease prognosis;Disease stratification;effective therapy;Endothelium;experience;experimental analysis;Experimental Models;Factor XI;Frequencies;Functional disorder;Galactose;Genetic;Glycocalyx;Glycoproteins;Glycoside Hydrolases;Goals;Half-Life;Health;Health Care Costs;Hemostatic function;Heparitin Sulfate;Hepatocyte;Human;human disease;Hyaluronan;Hyaluronic Acid;hypoperfusion;Immune response;Incidence;Infection;Inflammation;Innate Immune Response;insight;Intensive Care Units;Interleukin-10;Investigation;Knowledge;Kupffer Cells;Lectin;Lectin Receptors;Life;Link;Long term disability;Macrophage;Malignant Neoplasms;Membrane Glycoproteins;microorganism;Molecular;mortality;Neuraminidase;novel;novel marker;novel strategies;Organ;Outcome;pathogen;Pathogenesis;pathogenic bacteria;patient prognosis;Patients;Peer Review;Plasma;Polysaccharides;Process;Prognosis;prognostic;programs;Protein Glycosylation;Proteins;Proteome;Proteomics;Protocols documentation;Publications;receptor;Regulation;Research;Role;Salmonella;Sampling;Scientist;senescence;Sepsis;septic patients;Serology;Serum;Severity of illness;Stratification;Survivors;Syndrome;Therapeutic;Thrombosis;Tissues;Urine;vascular factor;Vascular remodeling;Vascular System;Virulence

PROJECT_TITLE: Protein Glycosylation in the Coagulopathy and Inflammation of Sepsis

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(JA)]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Sepsis

PROJECT_TERMS: Accreditation;Address;Blood Coagulation Disorders;Board Certification;California;Certification;Communication;Communication Programs;Communications Personnel;Computers;Core Facility;Data;Documentation;Electronic Mail;Event;Expenditure;Faculty;Funding;Glycoproteins;Goals;Hospital Departments;Hospitals;Human Resources;human subject;Inflammation;Infrastructure;Institution;inter-institutional;Internet;Laboratory Personnel;Letters;Link;Medical;meeting reports;meetings;member;Monitor;National Heart, Lung, and Blood Institute;operation;Participant;Persons;Physicians;Play;programs;Progress Reports;Protein Glycosylation;Publications;Records;Reporting;Research;Research Activity;Research Contracts;Research Personnel;Research Project Grants;Research Support;Role;Sepsis;Services;Site;Structure;success;Travel;Universities;verbal;Work;Writing

PROJECT_TITLE: CORE A - Administrative Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Public Health Relevance Statement: Data obtained from these studies are expected to define novel molecular mechanisms by which gut microbial choline metabolism contributes to the susceptibility of metabolic diseases including cardiovascular disease, obesity, and diabetes. This work will define a pathway whereby gut microbes can control the human circadian clock to induce these common diseases.

PI_NAMEs: BROWN, JONATHAN MARK (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: Address;Adipose tissue;Amines;Atherosclerosis;Bile Acids;blood glucose regulation;Cardiometabolic Disease;Cardiovascular Diseases;Carnitine;Choline;Chronic Kidney Failure;Chronotherapy;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Communication;Communities;Cues;Data;Development;Diabetes Mellitus;Diet;Disease;Drug Targeting;Endocrinology;Energy Metabolism;Environment;Environmental Risk Factor;Enzyme Inhibitor Drugs;Enzymes;Fatty acid glycerol esters;Feedback;FMO3;Food;G-Protein-Coupled Receptors;Genome;Germ-Free;gut microbes;gut microbiome;Hepatic;High Fat Diet;Homeostasis;Homo sapiens;hormonal signals;host microbiota;Human;Human body;human disease;improved;Ingestion;inhibitor;insight;Insulin Resistance;integrated circuit;Intestines;Jet Lag Syndrome;Lecithin;Levocarnitine;Light;Link;Lipids;Liver;Lyase;Malignant Neoplasms;Metabolic;Metabolic Diseases;Metabolism;Microbe;microbial;Micronutrients;Molecular;Mus;mutant;novel;Nutrient;Obesity;Oxides;Pathogenesis;Pathway interactions;Peripheral;pharmacologic;Phase;Phosphatidylcholine Biosynthesis;Phospholipid Metabolism;Pollution;Predisposition;prevent;Production;public health relevance;Publishing;receptor;Regulation;resident commensals;response;shift work;Signal Transduction;Skeletal Muscle;small molecule;symbiont;Testing;Therapeutic;Thrombosis;TPD52L1 gene;Transplantation;Volatile Fatty Acids;Work

PROJECT_TITLE: Metaorganismal Endocrinology in Cardiometabolic Disease


PI_NAMEs: LE, DZUNG T (contact)

PROJECT_TERMS: Address;Albumins;Alkaline Phosphatase;Anticoagulants;Anticoagulation;Antiplasmin;antithrombin III-protease complex;Bicarbonates;Biological Assay;Blood;Blood Cells;Blood Coagulation Disorders;Blood Coagulation Factor;Blood Platelets;Blood specimen;Calcium;Cellular Morphology;Chemicals;Chemistry;Chlorides;Clinical;Coagulation Process;Complete Blood Count;Core Facility;Creatinine;Data;Electrolytes;Enzymes;Erythrocyte Indices;Erythrocytes;Factor XI;Fibrin fragment D;Fibrinogen;Fibrinolysis;Geography;Giemsa stain;Glucose;Glycoproteins;Hematology;Hematopoietic System;Hemostatic Agents;Hemostatic function;Heparin;High Density Lipoproteins;Hour;Human;Human Volunteers;Immunoglobulin G;Immunoglobulins;Infection;Inflammation;Kidney;Leukocytes;Lipids;Liver;liver function;Low-Density Lipoproteins;Measurement;Measures;Metabolic;Metabolism;Microscopic;Morbidity - disease rate;Morphology;mortality;Mus;Organ;Pancreas;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Patients;peripheral blood;Phosphorus;Plasma;Platelet Count measurement;platelet function;Potassium;programs;Protein C;Protein Glycosylation;Protein S;Proteins;Prothrombin;Red Blood Cell Count;Sampling;Sepsis;Serology;Serum;Sodium;Standardization;Stratification;Testing;TFPI;Thrombin;Thromboplastin;total measurement Bilirubin;Von Willebrand antigen;White Blood Cell Count procedure;Whole Blood

PROJECT_TITLE: CORE B - Hematology, Chemistry and Coagulation Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cocaine;Drug Abuse (NIDA only);Neurosciences;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it seeks to understand how cocaine dysregulates striatal circuit activity to affect cocaine abuse. This research will define how a history of cocaine taking alters the synaptic plasticity of distinct intra-striatal circuits to affect neuronal excitability and drive cocaine seeking and taking. Our work aligns with the mission of the NIDA because it seeks to define the neural circuit conse- quences of cocaine use that underlie the continued seeking of cocaine following drug abstinence.

PI_NAMEs: DOBBS, LAUREN K (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Action Potentials;Affect;Attenuated;Automobile Driving;Axon;Behavior;Cells;Cocaine;Cocaine Abuse;cocaine cue;cocaine exposure;cocaine reward;cocaine seeking;cocaine self-administration;cocaine use;conditioned place preference;Corpus striatum structure;Coupled;Cues;Data;Disinhibition;Distal;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;Dopamine Receptor;Dose;drug abstinence;Drug usage;Dynorphins;Electrophysiology (science);endogenous opioids;Enkephalins;Epidemiology;Foundations;gamma-Aminobutyric Acid;Genotype;Globus Pallidus;Goals;Health;Immunohistochemistry;Induced Neurons;insight;Intake;Knock-out;Knockout Mice;Lead;Link;Long-Term Depression;Measures;Mediating;Messenger RNA;Mission;motivated behavior;Motivation;mu opioid receptors;Mus;National Institute of Drug Abuse;neural circuit;neuronal excitability;Neurons;novel;Opioid;Opioid agonist;Opioid Antagonist;Opioid Peptide;Opioid Receptor;Opsin;optogenetics;Outcome;Output;Pathway interactions;Peptides;Pharmaceutical Preparations;Pharmacology;Population;preference;Procedures;Protease Inhibitor;Protocols documentation;Psychological reinforcement;Public Health;Receptor Signaling;Recording of previous events;Regulation;Reporting;Research;response;restraint;Rewards;Saline;Signal Transduction;Slice;Source;stem;Surveys;Synaptic plasticity;Testing;Training;transmission process;Western Blotting;Work

PROJECT_TITLE: Regulation of striatal microcircuits by endogenous opioids as a novel mechanism underlying cocaine seeking

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases

ORG_CITY: COLUMBIA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: Project Narrative Many viruses regulate host T cell immunity in order to establish persistent infections. Sphingosine kinase (SK) 2 was demonstrated to regulate virus-induced immune suppression as well as T cell-mediated immune pathology. Therefore, investigating the molecular and cellular mechanisms by which viruses utilize SK2 to induce immune suppression could help us design innovative immune therapeutics to treat chronic viral infections.

PI_NAMEs: HAHM, BUMSUK  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Acceleration;Adoptive Transfer;Affect;Animal Model;Biological Models;Biological Process;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Nucleus;Cells;Chronic;chronic infection;Data;design;Disease;effectiveness evaluation;Enzymes;Generations;Genes;Goals;Hepatitis C virus;Human;Immune;Immune response;Immune system;Immunity;immunopathology;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Infection;Inflammatory Response;inhibitor;innovation;Interleukin-10;Kidney;Kidney Diseases;Kidney Failure;Lymphocytic choriomeningitis virus;Mediating;migration;Molecular;Morbidity - disease rate;mortality;Mouse Strains;Mus;neoplastic cell;novel;Oral Administration;Pathologic;Pathology;Pathway interactions;Patients;Process;programmed cell death protein 1;Proliferating;Regulation;Research;Resolution;Role;Sphingosine;sphingosine 1-phosphate;sphingosine kinase;Study models;T cell response;T-Lymphocyte;Testing;theories;therapy development;Treatment Efficacy;treatment optimization;tumor progression;Viral;Virus;Virus Diseases;Wild Type Mouse

PROJECT_TITLE: Regulation of host immunity to impact virus persistence

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: ANN ARBOR

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Public Health Impact: Diffuse intrinsic pontine glioma (DIPG) is an incurable pediatric cancer with a 100% mortality rate. We propose that the development and recurrence of DIPG tumors are driven by cancer stem cells (CSCs), a treatment-resistant subpopulation of DIPG cells. We will investigate how DIPG stem cells develop resistance by identifying regulators of ALDH, a driver of resistance, as we devise new and combination therapies that target the epigenetic stemness characteristics of these tumors.

PI_NAMEs: GALBAN, STEFANIE  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Acceleration;Address;aldehyde dehydrogenases;Aldehydes;Automobile Driving;Biological Assay;Cancer Biology;cancer cell;cancer stem cell;CASP3 gene;Cell Differentiation process;Cells;Characteristics;Chemotherapy and/or radiation;Childhood;Childhood Brain Neoplasm;Clinical;clinical predictors;clinical translation;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;combinatorial;Combined Modality Therapy;Data;Death Rate;design;Development;Diagnosis;Diffuse intrinsic pontine glioma;Disease;Disulfiram;DNA Repair Gene;Dose;Drug resistance;Drug Synergism;druggable target;efficacious treatment;Epigenetic Process;Exhibits;FRAP1 gene;Gliomagenesis;Goals;H3 K27M mutation;Histones;Hydrogenase;Immune;Immune Evasion;Immunity;Immunosuppression;In Vitro;in vivo;inhibitor;innovation;Interleukin-1 beta;Intervention Studies;Knowledge;Literature;Malignant Childhood Neoplasm;Metabolism;Methylation;Microglia;Modeling;mouse model;mTOR inhibition;mTOR Inhibitor;multidisciplinary;mutant;Mutation;Natural History;novel therapeutics;oncohistone;Outcome;overexpression;Patients;Penetrance;Pharmaceutical Preparations;Phase I Clinical Trials;PIK3CG gene;pre-clinical;preclinical study;prevent;programs;Protein Isoforms;Public Health;Publications;radiation resistance;Radiation therapy;Radiation Tolerance;radioresistant;Recurrence;Recurrent tumor;Regulation;Relapse;Reporter;Reporting;Research;Resistance;Resistance development;resistance mechanism;response;Role;Scheme;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Small Interfering RNA;standard of care;stem;stem cell biology;stem cell niche;stem cells;stemness;synergism;targeted treatment;Technology;Therapeutic;therapeutic development;Therapeutic Intervention;therapy resistant;transcriptomics;translational therapeutics;Treatment Efficacy;tumor;Tumor Immunity;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion

PROJECT_TITLE: Epigenetically regulated stemness program and stem cell niche as targets in pediatric DIPG

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


PROJECT_TERMS: Address;B-Lymphocytes;Basophils;Biological;Biological Assay;Blood;Blood Cells;Blood Coagulation Disorders;Blood Platelets;Blood Proteins;Blood specimen;Board Certification;Breeding;Calibration;Cell Lineage;Cells;Clinical;cohort;Cohort Studies;Collaborations;Colony-forming units;Comparative Study;Containment;Core Facility;cytokine;Data;Data Set;Dedications;design;Disease;Documentation;eosinophil;Equipment;Erythrocytes;experimental analysis;experimental study;genetic strain;Glycoproteins;Growth Factor;Health;Hematocrit procedure;Hematologist;Hematology;Hemoglobin;Hour;Human;Human Resources;Human Volunteers;Immune;Infection;Inflammation;Inflammatory;inflammatory marker;instrumentation;intraperitoneal;Intravenous;Intubation;Laboratories;Laboratory mice;Leukocytes;Location;Maintenance;Mass Spectrum Analysis;Measurement;Measures;Monitor;monocyte;Mouse Strains;Mus;neutrophil;Oral;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Physiological;Plasma;Process;programs;Protein Glycosylation;Proteins;Protocols documentation;Publications;Publishing;Quarantine;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;response;Route;sample collection;Sampling;Sepsis;septic;septic patients;Serum;Site;Standardization;Stomach;Stratification;synergism;System;Techniques;Technology;Tissues;Training;training project;Travel;Urine;Whole Blood

PROJECT_TITLE: CORE C - Infection and Inflammation Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: BALTIMORE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project narrative High-throughput molecular technologies are increasingly being used in biomedical and basic science. We will develop data science tools to enable researchers to take advantage of high-throughput technologies.

PI_NAMEs: HANSEN, KASPER DANIEL (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Basic Science;Binding;Biological Assay;Cell Cycle;Cell Physiology;complex data;Data Science;Development;DNA Methylation;epigenomics;experimental study;flexibility;genomic data;high throughput technology;histone modification;insight;Measurement;Measures;Methods;Molecular;Molecular Biology;nanopore;new technology;Research Personnel;Resolution;single-cell RNA sequencing;Statistical Methods;Technology;tool;transcription factor

PROJECT_TITLE: Data Science Tools to Increase Insight in Genomics Data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Hypertension;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: COLLEGE STATION

ORG_DEPT: PSYCHIATRY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE  Psychological trauma, and its pathological sequelae known as post-traumatic stress disorder (PTSD), increases the risk of developing cardiovascular diseases including hypertension by over 50%. Understanding that inflammation is a major regulator of hypertension, the main objective of this grant is to identify how psychological trauma initiates inflammation to lead to hypertension. Interventions that attenuate inflammation after psychological trauma may prevent life-threatening cardiovascular events in patients with PTSD.

PI_NAMEs: CASE, ADAM J (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Angiotensin II;Animal Model;Animals;anxiety-like behavior;Attenuated;Autocrine Communication;Behavioral;Biological;Biological Markers;Blood Pressure;blood pressure regulation;Cardiovascular Diseases;Cardiovascular system;Catecholamines;Cells;Chronic;Clinical;Clinical Management;Collection;Communities;comorbidity;COVID-19 pandemic;cytokine;Data;Denervation;designer receptors exclusively activated by designer drugs;Development;Disease;Elements;Environment;Enzymes;Event;General Population;Genetic Engineering;genetic manipulation;Goals;Grant;Hypertension;hypertensive;IL17 gene;Immune System Diseases;Incidence;Inflammation;Inflammatory;innovation;Interleukin-10;Interleukin-2;interleukin-22;Intervention;Knockout Mice;Laboratories;Life;Link;Mental disorders;Messenger RNA;Mitochondria;Modeling;mortality;mouse model;Mus;Neuroimmune;Neurologic;Neurons;neuroregulation;neurotransmission;new therapeutic target;Norepinephrine;novel;Operative Surgical Procedures;Organ;Oxidation-Reduction;Paracrine Communication;Pathogenesis;Pathologic;Pathway interactions;patient population;Patients;Peptides;Physiological;Post-Traumatic Stress Disorders;pre-clinical;Pre-Clinical Model;Predisposition;prevent;Production;psychologic;psychological trauma;Public Health;Reactive Oxygen Species;Regulation;response;Risk;screening;Signal Pathway;Signal Transduction;social defeat;Source;Spleen;Stress;Superoxides;Sympathetic Nervous System;T-Lymphocyte;targeted treatment;Techniques;Technology;Testing;Therapeutic Intervention;TNF gene;Tyrosine 3-Monooxygenase;United States

PROJECT_TITLE: Neuroimmune dynamics involved in the pathogenesis of hypertension after psychological trauma

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


PI_NAMEs: SMITH, JEFFREY W (contact)

PROJECT_TERMS: Address;Blood Coagulation Disorders;Blood Vessels;Cell surface;Circulation;Communication;Core Facility;disease prognosis;Disease stratification;Disseminated Intravascular Coagulation;Exhibits;Fractionation;Funding;Glycoproteins;Glycoside Hydrolases;gram-negative sepsis;Human;human disease;Inflammation;Lectin Receptors;Link;Mass Spectrum Analysis;Molecular;mouse model;Nature;Organ;pathogen;Pathogenesis;Plasma;Prognosis;programs;Protein Glycosylation;Proteins;Proteome;Proteomics;Publications;Regulation;Research Project Grants;Role;Sepsis;Stratification;Surface;Time;Vascular remodeling;Virulence;Work

PROJECT_TITLE: CORE D - Proteomics Core


PROJECT_TERMS: Address;Age;aged;Aging;aging process;Alkaline Phosphatase;Anti-Inflammatory Agents;Asialoglycoprotein Receptor;Asialoglycoproteins;base;beta-Galactosidase;Biochemical;Blood;Blood Chemical Analysis;Blood Coagulation Disorders;Blood Coagulation Factor;Blood Platelets;Blood Proteins;Blood specimen;Blood Vessels;Cessation of life;Circulation;Clinical;Coagulation Process;Collaborations;comparative;Data;design;Development;Diagnosis;Diagnostic;Disease;Disease Outcome;Disparate;Enzymes;Exoglycosidases;Failure;Functional disorder;Future;Galactose;Genetic;Glycoproteins;Glycoside Hydrolases;Half-Life;Health Care Costs;healthy volunteer;Hematology;Hemostatic function;Hepatocyte;Homeostasis;Human;human data;human mortality;Immune response;Impaired cognition;Infection;Inflammation;insight;intravital microscopy;Investigation;Kinetics;Kupffer Cells;Laboratories;Lectin;Lectin Receptors;Ligands;Link;Location;Macrophage;Malignant Neoplasms;Measurement;Measures;Medical Records;Membrane Glycoproteins;Metabolic Clearance Rate;Molecular;mortality;mouse model;Mus;Neuraminidase;Organ failure;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;patient health information;Patient-Focused Outcomes;Patients;Phenotype;Plasma;platelet homeostasis;Process;Production;prognostic;prognostic indicator;programs;Protein Glycosylation;Proteins;Proteome;Proteomics;proteostasis;rate of change;receptor;Regulation;Research;Role;Sampling;senescence;Sepsis;septic patients;Severity of illness;Sialic Acids;sialylation;Signal Transduction;Specificity;Stratification;Survivors;Syndrome;Therapeutic;therapeutically effective;Thrombosis;Toxin;Urine;Vascular System;volunteer

PROJECT_TITLE: PROJECT 1 - Host Neuraminidases in Hemostasis and Sepsis


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Gene regulatory elements control human development, disease susceptibility and progression, and almost all complex human traits, however we understand how very few of the millions of putative regulatory elements in the human genome function. The goal of the Duke IGVF Characterization Center is to systematically and comprehensively characterize the function of gene regulatory elements and their variants in diverse biological contexts. We will make our data, resources, reagents, and analysis tools immediately available to the scientific community.

PI_NAMEs: CRAWFORD, GREGORY E;GERSBACH, CHARLES A. (contact);REDDY, TIMOTHY E

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: 3-Dimensional;Biological;Biological Assay;Biological Process;Cataloging;Catalogs;causal variant;cell fate specification;cell growth;Cell Lineage;Cell Survival;cell type;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;Coupled;CRISPR screen;CRISPR/Cas technology;Cultured Cells;Data;delivery vehicle;Development;Disease;Disease Progression;Disease susceptibility;Elements;Environment;Environmental Risk Factor;epigenome editing;epigenomics;fitness;Gene Expression;Gene Expression Regulation;gene function;Gene Order;Genes;Genetic Polymorphism;Genetic Variation;Genome;genome annotation;genome-wide;genomic variation;Genomics;Genotype-Tissue Expression Project;Goals;Guide RNA;Hepatocyte;Homeostasis;Human;Human Development;Human Genetics;Human Genome;in vitro Model;in vivo;induced pluripotent stem cell;Learning;Libraries;Link;Linkage Disequilibrium;Maintenance;Maps;Methods;mouse model;Mus;Muscle Cells;Natural regeneration;Neurons;novel;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;population based;Positioning Attribute;Protocols documentation;Quantitative Trait Loci;Reagent;Regulatory Element;Reporter;Resources;response;Role;Shapes;single-cell RNA sequencing;Specific qualifier value;Stimulus;Suspensions;tissue regeneration;Tissues;tool;trait;Transgenic Organisms;Undifferentiated;Untranslated RNA;Variant;Viral;Viral Vector;whole genome

PROJECT_TITLE: High-Throughput Functional Annotation of Gene Regulatory Elements and Variants Critical to Complex Cellular Phenotypes


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Foodborne Illness;Hematology;Infectious Diseases;Sepsis

PI_NAMEs: MAHAN, MICHAEL J (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Alkaline Phosphatase;Anti-Inflammatory Agents;Bacteria;biomarker discovery;Blood;Blood Coagulation Disorders;Blood Coagulation Factor;Bone Marrow;Cells;Circulation;Clinical;Coagulation Process;Core Facility;Coupled;Cultured Cells;cytokine;Data;design;diagnostic biomarker;Disease;Disease Outcome;Disseminated Intravascular Coagulation;Drug Metabolic Detoxication;enteric infection;Enzymes;Escherichia coli;Exhibits;Factor Analysis;Factor XI;Factor XI Deficiency;Food Poisoning;Functional disorder;Generations;Genetic;Genetic Transcription;Glycobiology;Glycoproteins;Goals;gram-negative sepsis;Grant;Growth;Hematology;Host Defense;Human;Immune;Immune response;Immune system;Infection;Inflammation;Inflammatory;Innate Immune Response;Interleukin-10;Link;Macrophage;microbial;Molecular;mortality;Mus;mutant;Natural Selections;Nature;Neuraminidase;Organism;Osteomyelitis;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patient-Focused Outcomes;Pattern;Plasma;Production;Prognosis;programs;Protein Glycosylation;Proteome;Proteomics;rational design;receptor;Research;response;Risk;Role;Salmonella;Salmonella typhimurium;Sepsis;septic;septic patients;Severities;Stratification;Testing;Therapeutic Agents;Variant;Virulence;Virulent

PROJECT_TITLE: PROJECT 2 - Mechanisms of Hypervirulence in the Pathogenesis of Sepsis


NIH_SPENDING_CATS: Nutrition

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE The research training provided by this program, based in an academic medical center, will accelerate the development of the next generation of physician-scientists and PhD researchers in the field of Nutrition. Research areas include obesity and its health effects, nutrition and eating behavior, and the effects of nutrition over entire lifespan, and the approaches span from bench to bedside to community-based research. All fellows will be poised to launch successful independent research careers in translational Nutrition science and to be leaders in disease prevention and health promotion.

PI_NAMEs: KREBS, NANCY F (contact)

PROGRAM_OFFICER_NAME: KAMARA, FANTA

PROJECT_TERMS: Institution;nutrition;Training Programs

PROJECT_TITLE: Institutional Training Program in Nutrition


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Prevention

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Men in sub-Saharan Africa who test HIV-positive continue to have poor ART initiation and retention outcomes. The proposed project will test a home-based ART intervention for men who use HIV self-testing (HIVST) strategies compared to facility-based ART. Findings will provide essential information on how to best reach men across the testing and treatment continuum, a critical step to curbing the HIV epidemic.

PI_NAMEs: DOVEL, KATHRYN L (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Address;Adverse event;Africa South of the Sahara;arm;Baseline Surveys;Caring;Characteristics;Client;Clinical;Coping Skills;cost;Cost Analysis;cost comparison;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness ratio;Decision Making;design;Diagnostic Reagent Kits;Disclosure;effectiveness testing;Enrollment;Epidemic;experience;Female;Friends;Fright;Gender;Goals;Health Services Accessibility;high risk men;HIV;HIV Seropositivity;Home;Human immunodeficiency virus test;improved;incremental cost-effectiveness;indexing;Individual;innovation;Intention;International;Intervention;Interview;Joints;Knowledge;Location;Malawi;male;men;Modeling;motivational enhancement therapy;novel strategies;Outcome;peer;Perception;Phase;Policies;Population;Privacy;Public Health;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Safety;scale up;self testing;service delivery;Services;Sexual Partners;social stigma;sociodemographics;standard of care;Testing;testing services;Time;transmission process;treatment services;uptake;Use Effectiveness;Viral;Viral Load result;Woman;Work

PROJECT_TITLE: Engaging men through HIV self-test and differentiated care models to increase ART initiation and viral suppression in Malawi

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Immunization;Infant Mortality;Infectious Diseases;Pediatric;Prevention;Vaccine Related

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Despite ongoing surveillance and control efforts, Group B Streptococcus (GBS) remains an important cause of neonatal sepsis and is emerging as an etiology of adult infection. Vaccine candidates that protect against some GBS serotypes have moved into human trials, but we still do not understand why some serotypes are more common than others, and there has been a recent increase in non-vaccine type GBS infections in the US. We propose a program of research to delineate rates of vaccine- and non-vaccine-type GBS and determine the role of GBS capsule and non-capsule genes to colonization and invasive infection of humans.

PI_NAMEs: RATNER, ADAM JONATHAN (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Active Sites;Address;Adult;Alleles;Animal Model;Antibiotics;antimicrobial;Bacterial Genes;bacterial genetics;Biological Assay;Biology;candidate identification;capsule;Characteristics;Clinical;comparative;Conjugate Vaccines;cost;Data;Disease;Epidemiology;epidemiology study;Etiology;fitness;Frequencies;Genes;Genetic;Genome;genome sequencing;genomic locus;Genomics;Goals;Group B Streptococcus colonization;Human;in vivo;Infant;Infection;intrapartum;Laboratories;Metadata;Morbidity - disease rate;mortality;mouse model;mutant;Mutation;Neonatal;Neonatal Mortality;neonatal sepsis;Pathogenesis;Pathogenicity;Polysaccharides;Population;Pregnant Women;Prevalence;Prevention;programs;Prophylactic treatment;Prospective Studies;Research;Research Design;Risk;Risk Factors;Role;Sampling;screening;screening program;Serotyping;Streptococcal Infections;Streptococcus Group B;success;System;Techniques;Testing;tool;Vaccination;vaccine candidate;vaccine development;Vaccines;whole genome

PROJECT_TITLE: Capsular serotype in group B Streptococcus colonization and disease

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ORG_CITY: DETROIT

ORG_NAME: INTERNATIONAL UNION, UAW OF AMER AFL-CIO

PHR: Project Narrative  The International Union, UAW and its partners propose to address three problems. The first is the potential for illness and injury directly or indirectly related to hazardous material exposure. The second is occupational and environmental health disparities (Strategic Plan Goal 4 for Promoting Translation), particularly as they affect the Hispanic/Latino population of Southeast Michigan. The third problem is the opioid epidemic, an emerging environmental health issue (Strategic Plan Goal 5 for Promoting Translation). We propose to conduct training in health and safety in order to address the potential for illness and injury directly or indirectly related to hazardous material exposure by conducting training in health and safety. We will address occupational and environmental health disparities by continuing and expanding collaborative partnerships with community groups and other NIEHS-WTP grantees for the purpose of delivering health and safety training to underserved populations. The opioid crisis will be addressed by developing and delivering population-specific curricula that address treatment and prevention of opioid addiction, including alternatives for pain management. In addition, we propose to develop, pilot, evaluate and scale a peer recovery support program that will help workers seek services to address opioid addiction. All of the above programs will be evaluated to provide feedback for continual improvement of curricula and delivery methods. This will include monitoring trainee perceptions of quality, appropriateness, and usefulness as well as assessing new curricula and training delivery methods; evaluating the long-term impact of training on worker and organizational outcomes using innovative and conventional quantitative and qualitative evaluation methods. Worker trainers will be involved in evaluations when possible. In doing all of the above, we further EPA’s mission to protect human health and the environment and Congress’s purpose in passing the Occupational Safety and Health Act of 1970 “to assure so far as possible every working man and woman in the nation safe and healthful working conditions…”

PI_NAMEs: SIVIN, DARIUS D (contact)

PROGRAM_OFFICER_NAME: BEARD, SHARON

PROJECT_TERMS: Address;Affect;Agriculture;Air Pollutants;Blood-Borne Pathogens;carcinogenicity;Carcinogens;Charities;Child Care;chromium hexavalent ion;Chronic;Cohort Studies;Communities;Congresses;County;Dangerousness;Development;Diagnosis;Disadvantaged;Dust;Education;Educational Curriculum;Environment;Environmental Health;environmental health disparity;Evaluation;Exposure to;extreme temperature;Face;Feedback;Goals;Grant;hazard;Hazardous Substances;Health;Healthcare;Hispanic;Hour;Housekeeping;Human;Hurricane;improved;Injury;innovation;International;Island;Latino;Latino Population;Limited English Proficiency;manufacture;member;Methods;Michigan;Mission;Monitor;nanoengineering;nanomaterials;National Institute of Environmental Health Sciences;Occupational Health;occupational health/safety;Occupations;Opiate Addiction;opioid epidemic;opioid use disorder;Outcome;outreach services;Pain management;Participant;peer recovery;Perception;Persons;Pesticides;Population;prescription opioid;prevent;Prevention;Program Evaluation;programs;Puerto Rico;Qualitative Evaluations;Quantitative Evaluations;Radioisotopes;Recovery Support;Safety;Seasons;Services;Silicon Dioxide;Solvents;Strategic Planning;Tobacco smoke;Training;translational goal;Translations;Ultraviolet Rays;Underserved Population;United States;Universities;Welding;Work;working men;Working Women

PROJECT_TITLE: UAW Hazardous Material Worker Health and Safety Training (U45)


NIH_SPENDING_CATS: Brain Disorders;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Prevention;Racial and Ethnic Minority Health Research;Recovery Support Services;Social Determinants of Health;Substance Misuse

PROJECT_TERMS: Address;Affect;Agriculture;Air Pollutants;Blood-Borne Pathogens;carcinogenicity;Carcinogens;Charities;Child Care;chromium hexavalent ion;Chronic;Cohort Studies;Communities;County;Dangerousness;Development;Diagnosis;Disadvantaged;Dust;Education;Educational Curriculum;Environmental Health;environmental health disparity;Evaluation;Exposure to;extreme temperature;Face;Feedback;Goals;Grant;hazard;Hazardous Substances;Health;Healthcare;Hispanic;Hour;Housekeeping;Hurricane;improved;Injury;innovation;International;Island;Latino;Latino Population;Limited English Proficiency;manufacture;member;Methods;Michigan;Monitor;nanoengineering;nanomaterials;National Institute of Environmental Health Sciences;Occupational Health;Occupations;Opiate Addiction;opioid epidemic;opioid use disorder;Outcome;outreach services;Pain management;Participant;peer recovery;Perception;Persons;Pesticides;Population;prescription opioid;prevent;Prevention;Program Evaluation;programs;Puerto Rico;Qualitative Evaluations;Quantitative Evaluations;Radioisotopes;Recovery Support;Safety;Seasons;Services;Silicon Dioxide;Solvents;Strategic Planning;Tobacco smoke;Training;translational goal;Ultraviolet Rays;Underserved Population;United States;Universities;Welding;Work


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Hematology;Infectious Diseases;Sepsis

PI_NAMEs: ESKO, JEFFREY D (contact)

PROJECT_TERMS: 3-Dimensional;Address;Affect;antagonist;Beds;Biology;Blood Coagulation Disorders;Blood Vessels;Brain;Cardiac;Cell surface;Cells;Clinical;Coagulation Process;Core Facility;Data;diagnostic biomarker;Disease;Endothelial Cells;Endothelium;Extravasation;Glycobiology;Glycocalyx;Glycoproteins;Goals;Grant;Heart;Hemolysin;Heparin;Heparin Lyase;Heparitin Sulfate;Host Defense;Human;Hyaluronan;Hypersensitivity;Immune response;in vivo;Infection;Infectious Agent;Inflammation;Inflammatory;Inflammatory Response;Intoxication;Literature;Liver;Lung;Mediating;Metabolism;methicillin resistant Staphylococcus aureus;Methods;Monitor;mortality;mouse model;Mus;Mutation;novel marker;Organ;Outcome;pathogen;pathogenic bacteria;Pathogenicity;Pathologic;Patients;Plasma;Play;Predisposition;Prognostic Marker;programs;Protein Glycosylation;Proteoglycan;Proteome;Proteomics;Publishing;Research;Resolution;response;Role;Sampling;Sepsis;septic patients;Severities;Spleen;Staphylococcus aureus;Staphylococcus aureus infection;Testing;Time;Tissues;Vascular Diseases;Vascular Endothelium;Vascular remodeling;Virulence Factors

PROJECT_TITLE: PROJECT 3 - Infection-Induced Remodeling of the Vascular Proteome


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition;Prevention

PHR: PROJECT NARRATIVE Ulcerative colitis (UC) and Crohn’s disease (CD) are chronic, immune-mediated disorders caused by a maladaptive, dysregulated inflammatory response to gut bacteria, affecting nearly 1.6 million individuals in the U.S. alone. In this proposal, we will comprehensively investigate the complex interplay between the foods we eat, gut microbial communities, and the relapsing/remitting course of the inflammatory bowel diseases (IBD). Elucidating this relationship—particularly the role of sulfur-metabolizing bacteria capable of breaching the protective mucus bilayer of the gastrointestinal tract—would represent a critical and timely step forward in our mechanistic understanding of IBD pathogenesis and offers the promise of a dietary-based treatment strategy centered upon modulation of bacterial ecology.

PI_NAMEs: NGUYEN, LONG H (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Address;Affect;Area;Bacteria;Biochemical Pathway;Calories;candidate identification;Cataloging;Chemicals;Chronic;Clinical Trials Design;cohort;Colitis;Collection;colorectal cancer risk;Communities;comparative;Complex;computer framework;Control Groups;Crohn's disease;Data;design;Development;Diet;Diet Modification;dietary;Dietary Assessment;Dietary intake;Dietary Intervention;Dietary Sulfur;Disease;Disease remission;Disparity;distilled alcoholic beverage;disulfide bond;Disulfides;dysbiosis;Eating;Ecology;Enzymes;Epithelium;Equipment and supply inventories;Expert Opinion;Feces;Food;food avoidance;Friends;Funding;Gastrointestinal Diseases;Gastrointestinal tract structure;General Hospitals;Genes;Genetic Transcription;genetic variant;Genomics;Goals;gut bacteria;gut inflammation;gut microbiome;gut microbiota;Health Transition;Homeostasis;Human;Human Microbiome;Hydrogen Sulfide;Immune;Immune response;improved;indexing;Individual;Inflammatory Bowel Diseases;Inflammatory Response;Informatics;innovation;insight;Intervention;Lead;Leukocyte L1 Antigen Complex;Link;Literature;Manuals;Massachusetts;Measures;Mediating;member;Mentors;Metabolic;metabolomics;metagenome;Metagenomics;metatranscriptomics;Methodology;Methods;Microbe;microbial;microbial homeostasis;microbiome;microbiome research;Mucous body substance;multidisciplinary;novel;Nutritional;open source;Outcome;Pathogenesis;Pathway Analysis;Patients;Phylogenetic Analysis;Physicians;Population;Process;Processed Meats;Proteins;Randomized, Controlled Trials;Recommendation;Relapse;Reporting;Research;Research Personnel;Research Project Grants;Resolution;Role;Sampling;Severity of illness;Starvation;Sulfoxide;Sulfur;Sulfur Metabolism Pathway;Sulfur-Reducing Bacteria;Taxonomy;Testing;Therapeutic;Training;treatment guidelines;treatment strategy;Ulcerative Colitis

PROJECT_TITLE: Dietary strategies for rational manipulation of the gut microbiome in inflammatory bowel disease


NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Gastrointestinal (GI) diseases are among the world’s most common ailments. For example, diarrheal disease causes over 5,000,000 deaths/yr world-wide. This grant proposes to provide physicians and other scientists training that will enable them to pursue clinical and basic science in GI health and disease.

PI_NAMEs: GORELICK, FRED SANFORD (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Gastroenterology;Training Programs

PROJECT_TITLE: Training Program in Investigative Gastroenterology


ADMINISTERING_IC: LM

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;HIV/AIDS;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The goal of Columbia University's training program is to advance health care and medicine through the advancement of the discipline of biomedical informatics. Our training program provides a research-oriented curriculum with rigorous formal training in informatics and data science integrated with exposure to real- world systems in clinical and research settings at our university, in our community, and around the world. Most of our graduates continue to advance the field through research as faculty members in academic institutions or in industry-based research facilities.

PI_NAMEs: ELHADAD, NOEMIE  (contact);HRIPCSAK, GEORGE M

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Area;Artificial Intelligence;Bioinformatics;biomedical informatics;Clinical;Clinical Informatics;Clinical Research;Data Science;Dedications;Discipline;Doctor of Philosophy;doctoral student;Education;Educational Curriculum;Educational process of instructing;Environment;Ethics;experience;Exposure to;Faculty;Funding;Health;Healthcare;HIV;Hospitals;Informatics;Information Systems;Information Technology;Instruction;International;Machine Learning;Methodology;New York;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Presbyterian Church;programs;Public Health Informatics;Qualitative Methods;Research;research faculty;Research Training;Running;Schools;Services;Training;Training Programs;United States National Library of Medicine;Universities

PROJECT_TITLE: Training in Biomedical Informatics at Columbia University


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Genetics;Human Genome;Regenerative Medicine

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: The salivary glands are exocrine glands that produce saliva. Dysfunction of salivary gland ion homeostasis can lead to several human diseases. We identify a unique ductal cell type, the salivary ionocyte that involved in regulation of ion homeostasis. We will determine factors that control salivary gland ionocyte differentiation and investigate how chronic inflammation affects ionocyte function.

PI_NAMEs: MAKARENKOVA, HELEN P. (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Acinar Cell;Acinus organ component;Adult;Affect;Anions;Biology;biomarker identification;Cell Separation;cell type;Cells;Characteristics;Chronic;Clinical Research;Collaborations;Complex;Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Disease;Disease Progression;Duct (organ) structure;Ductal Epithelial Cell;Ductal Epithelium;Electrolytes;Enzymes;Epithelial Cells;Epithelium;Exocrine Glands;experimental study;FGF10 gene;Fibroblast Growth Factor;fibroblast growth factor receptor 2b;Fluids and Secretions;Fluorescence-Activated Cell Sorting;Functional disorder;functional improvement;Future;Gene Expression;Genes;Gland;gland development;Heterogeneity;Homeostasis;human disease;human tissue;Immunoglobulins;Inflammation;injured;Injury;Intercalated Duct;Ion Transport;Ions;Knockout Mice;Maintenance;Mesenchymal;Mesenchyme;Modeling;mouse model;Mucins;Mus;Myoepithelial cell;Natural regeneration;novel;oral tissue;overexpression;Parotid Gland;Play;Population;postnatal;postnatal development;Process;Proliferating;Proteins;Proton-Translocating ATPases;Regulation;repaired;Research;RNA analysis;Role;Saliva;Salivary;Salivary duct structure;Salivary Glands;Signal Transduction;single cell analysis;single-cell RNA sequencing;Sjogren's Syndrome;Sorting;stem cell growth;Tamoxifen;Testing;Tetanus Helper Peptide;Thrombospondin 1;Tissues;Tomatoes;transcriptome sequencing;Transplantation;UXT gene;vacuolar H+-ATPase

PROJECT_TITLE: Salivary gland ionocyte organization and function during homeostasis, repair, and disease

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Malaria;Prevention;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE While traditional epidemiological approaches have resulted in significant reductions in malaria burden in many countries, scale up of targeted interventions to high-risk populations are critical to eliminate remaining parasite reservoirs in low-transmission settings. This study will apply novel genetic and social network analyses to survey data from malaria high-risk populations in Namibia to understand parasite and human connectivity and infer small scale malaria transmission patterns, intervention uptake, and potential impact of targeted intervention approaches. Results of this research will provide critical information whether targeted interventions in malaria high-risk populations hold promise for malaria elimination in this context and provide a template for tailoring interventions to optimize coverage and impact.

PI_NAMEs: SMITH, JENNIFER LINNEA (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Achievement;Address;Agricultural Workers;Alternative Therapies;analytical method;Biometry;California;career;career development;Characteristics;Communicable Diseases;Communities;cost;Country;Cross-Sectional Studies;Culicidae;Data;design;Disease Clusterings;epidemiologic data;Epidemiologic Methods;Epidemiology;Evaluation;Exposure to;Farm;Foundations;Funding;Genetic;genetic analysis;genetic approach;genetic epidemiology;Genotype;Geography;Goals;Health;Health Service Area;Health Services Accessibility;Heterogeneity;high risk;high risk population;Human;improved;Income;Individual;Infection;infection risk;infectious disease model;Influentials;Intervention;intervention delivery;Knowledge;Malaria;Malaria prevention;malaria transmission;mathematical model;Measures;Mentored Research Scientist Development Award;Mentors;Mentorship;Migrant;Modeling;Namibia;Network-based;novel;Parasites;Pathway Analysis;Pattern;peer;Persons;Play;Population;population based;Positioning Attribute;prevent;Prevention Measures;professor;Recommendation;Research;Research Personnel;Resolution;response;Risk;Role;San Francisco;scale up;Seasons;skills;social;social influence;Social Network;spatiotemporal;Stigmatization;Surveys;Testing;theories;Time;Training;transmission process;Travel;Universities;uptake;Variant;World Health Organization

PROJECT_TITLE: Genetic and social network analysis to target interventions for malaria elimination

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Correct regulation of inflammatory caspases is critical for preventing uncontrolled inflammation in response to hemolysis. The proposed research is relevant to public health because it will provide important mechanistic insights into how inflammatory caspases are regulated by extracellular heme, a key pathophysiological feature of several disease states. Thus, the proposed research is relevant to part of the mission of the National Institute of Allergy and Infectious Diseases (NIAID) that pertains to understanding, treating, and preventing infectious and immunologic diseases.

PI_NAMEs: BOUCHIER-HAYES, LISA  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Algorithms;Amino Acids;Apical;Bacteria;Binding;Biological Assay;biophysical properties;Biophysics;candidate identification;CASP1 gene;CASP5 gene;Caspase;Catalytic Domain;cell type;Cells;Clinical;cofactor;Communicable Diseases;Complex;cytokine;Data;Development;Dimerization;Disease;Drug Design;Drug Screening;Erythrocytes;experimental study;extracellular;Functional disorder;Future;Genetic Transcription;Goals;Heme;Hemolysis;Hemorrhage;Immune System Diseases;improved;In Vitro;in vitro Assay;Incubated;Individual;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;insight;Interleukin-1 beta;Length;Measures;Mediating;Mission;Molecular;monomer;Multiprotein Complexes;Mutate;National Institute of Allergy and Infectious Disease;Organ;Outcome;Pain;Pathway interactions;Pattern;Pharmaceutical Preparations;Plant Extracts;prevent;Proteins;Public Health;Radiolabeled;Recombinants;reconstitution;Regulation;Reporting;Research;response;scale up;Sepharose;Sepsis;Sickle Cell Anemia;Site-Directed Mutagenesis;Source;Structure;System;Testing;Translating;Work

PROJECT_TITLE: Development of an in vitro system to study heme-induced caspase activation

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Mental Health;Microbiome;Obesity;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE With over half of men and women living with HIV now over the age of 50 years and new HIV infections mainly in minority populations, it will be of critical importance to understand the influence of health disparities (socioeconomic and behavioral conditions by biologic sex and race/ethnicity) and biologic processes (gonadal aging, adiposity, immune perturbation) on fatty liver disease and its clinical sequelae (cardiac, neurocognitive, and bone injury) in persons with HIV and HCV infection in the current era of anti‐viral treatment. I propose to expand my research program by building collaborations with mentees across a range of disciplines (e.g. hepatology, endocrinology, cardiology, neuropsychology, immunology, pharmacology) and prioritizing mentorship of underrepresented minority investigators who can effectively contribute to the HIV communities most at risk today. Together they will enrich my research program and develop the next generation of clinical investigators in high priority HIV research.

PI_NAMEs: TIEN, PHYLLIS C (contact)

PROGRAM_OFFICER_NAME: JANCI, ELIZABETH WONDERLICH

PROJECT_TERMS: Acceleration;Adipose tissue;Affect;African American;African American Women;Age;Aging;Anti-Retroviral Agents;Anti-viral Agents;Award;Behavioral;behavioral health;Behavioral Sciences;Biological;Biological Markers;Biological Process;biological sex;Blood Vessels;Body Composition;bone;Bone Injury;Cardiac;Cardiology;Cardiovascular system;career;Central obesity;Clinical;Clinical Investigator;clinical translation;cohort;Cohort Studies;Collaborations;Communicable Diseases;Communities;Data;Discipline;Disease Progression;Disparity;Drug Exposure;Education;elastography;Endocrinology;Epidemiology;Estrogens;Ethnic Origin;Extrahepatic;Fatty Liver;fatty liver disease;Fibrosis;food security;Functional disorder;gastrointestinal epithelium;Gender;Goals;Gonadal Steroid Hormones;Grant;gut dysbiosis;gut microbiome;Hair;Health;health care availability;health disparity;Hepatitis C;Hepatitis C virus;Hepatology;High Risk Woman;Hispanic Women;HIV;HIV Infections;HIV/HCV;Immune;immune activation;Immunology;Income;indexing;Infection;Inflammation;Inflammatory;Infrastructure;inhibitor;Injury;Injury to Kidney;Integrase;Intestinal permeability;kidney fibrosis;latent HIV reservoir;Leadership;Liver;Liver Fibrosis;liver injury;Longitudinal Studies;Measurement;Medicine;men;Menopause;Mental Depression;Mental Health;Mentors;Mentorship;Metabolic;microbial;Microbiology;microbiome analysis;Minority Groups;minority investigator;Morbidity - disease rate;mortality;Neighborhoods;Neurocognition;Neurocognitive;Neuropsychology;next generation;non-alcoholic fatty liver disease;novel marker;Obesity;optimism;oral microbiome;organ injury;Outcome;Pathogenesis;Pathway interactions;patient oriented research;Perimenopause;Persons;Pharmacology;Plasma;Play;professor;programs;Race;Recommendation;Regimen;Reporting;Research;Research Personnel;Research Project Grants;Research Support;residence;Risk;Role;Sampling;Site;skills;Social Behavior;socioeconomics;Structure;systemic inflammatory response;Tenofovir;The Multicenter AIDS Cohort Study;Training;translational research program;Underrepresented Minority;vibration;Viral;Visceral;waist circumference;Weight Gain;Woman;Women's cohort;Women's Interagency HIV Study;Work

PROJECT_TITLE: HIV, HCV, and gender effects on Liver, Bone, and Vascular Health