NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Immunotherapy;Orphan Drug;Precision Medicine;Rare Diseases

PHR: PROJECT NARRATIVE − PROJECT 3  Although great strides have been made with immunotherapy for head and neck squamous cell carcinoma (HNSCC), only a minority of patients respond to anti-PD1 monotherapy. Thus, there is an imperative need to find better treatment options for these patients. LAG3 limits effector T cell function and exhibits synergy with anti-PD1 in mouse models of cancer, and thus is a logical therapeutic target to increase anti-tumor immunity in combination with anti-PD1. There are now 10+ LAG3-targeting therapeutic clinical trials in the US, and yet we still know very little about how LAG3 blockade, alone or in combination with anti-PD1, impacts the immune response to cancer, and whether biomarkers exist which could predict responsiveness.

PI_NAMEs: BRUNO, TULLIA CARMELA (contact)

PROJECT_TERMS: Aftercare;anti-PD-1;anti-PD1 therapy;Area;arm;Biological Markers;Biology;biomarker identification;Biopsy;cancer imaging;Cancer Model;Cancer Patient;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cell surface;Cells;Clinical Trials;cohort;Combination immunotherapy;combinatorial;Combined Modality Therapy;cytokine;Data;Development;Disease;effector T cell;Excision;Exhibits;Functional disorder;Genetic Transcription;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Homeostasis;IL6 gene;Immune;immune resistance;Immune response;Immune System Diseases;Immunotherapeutic agent;Immunotherapy;immunotherapy trials;improved;Inflammation;innovation;insight;interest;Link;Malignant Neoplasms;Mediating;Metalloproteases;Metastatic/Recurrent;Minority;Molecular;mouse model;Neoadjuvant Therapy;Nivolumab;novel;NRP1 gene;Operative Surgical Procedures;Pathway interactions;patient population;patient response;Patient-Focused Outcomes;Patients;PD-1 blockade;Peripheral;peripheral blood;Personal Communication;Phenotype;Plasma;predicting response;programmed cell death protein 1;programs;Proliferating;Randomized;receptor;receptor expression;Regulation;Research Personnel;Resistance;resistance mechanism;response;response biomarker;Series;single-cell RNA sequencing;spectrograph;standard of care;Surface;synergism;T cell receptor repertoire sequencing;T-Cell Activation;T-Cell Immunologic Specificity;T-Cell Proliferation;T-Lymphocyte;targeted treatment;Therapeutic Clinical Trial;therapeutic target;Tissues;tocilizumab;transcriptomics;tumor;Tumor Immunity;tumor microenvironment;Tumor Tissue;Validation

PROJECT_TITLE: Project 3: Determining biomarkers for responsiveness to immunotherapy targeting LAG3/PD1 in HNSCC


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PROVIDENCE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE The Center of Biomedical Research Excellence (COBRE) on Opioids and Overdose at Rhode Island Hospital, in the first four years of Phase 1, has successfully created a vibrant interdisciplinary Center of research excellence consisting of 4 Cores and a critical mass of investigators dedicated to addressing the opioid and overdose crisis. The COBRE has also mentored junior faculty Project Leaders into independently funded researchers. The proposed Phase 2 application will further improve the research infrastructure and continue to develop and strengthen the critical mass of investigators focused on an area of clinical research that is of urgent public health importance.

PI_NAMEs: RICH, JOSIAH D (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Accidental Injury;Address;Affect;Area;Award;career;career development;Caring;Centers of Research Excellence;Cessation of life;chronic pain patient;Clinical Research;Collaborations;community engaged research;community reintegration;Consultations;Country;COVID-19 pandemic;Data;Data Management Resources;data visualization;Dedications;Discipline;Disease;Doctor of Philosophy;early-career faculty;Education and Outreach;effective intervention;empowerment;Ensure;Ethics;Faculty;fentanyl use;Funding;Goals;heroin use;high risk population;Hospitals;implementation science;improved;Individual;Infrastructure;innovation;Institution;Investments;Joints;Knowledge;Lead;Leadership;Link;member;Mentors;Mentorship;Methodology;Motivation;multidisciplinary;open label;Opioid;opioid misuse;opioid overdose;opioid use;opioid use disorder;organizational structure;Overdose;Pattern;Peer Review;Phase;Pilot Projects;Placebos;Policies;Population;prescription opioid;prevent;Prevention approach;programs;Public Health;Publications;recruit;Research;Research Activity;Research Design;Research Infrastructure;Research Methodology;Research Peer Review;Research Personnel;Research Project Grants;Research Support;Resources;Rhode Island;Scientist;Senior Scientist;Services;Strategic Planning;Translational Research;Underserved Population;United States;United States National Institutes of Health;Vehicle crash;Vulnerable Populations;Work

PROJECT_TITLE: COBRE Center on Opioids and Overdose


ADMINISTERING_IC: CA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: The Montefiore Einstein Cancer Center (MECCC) seeks to reduce the burden of cancer through its basic, clinical, and population-based research and to take the scientific discoveries and bring them into clinical initiatives for the prevention, detection, and treatment of cancer. This is accomplished through MECCC’s four established research programs and eight shared resources. MECCC seeks to understand the molecular and epidemiologic basis for various cancers that arise in Bronx, the Center’s main catchment area.

PI_NAMEs: CHU, EDWARD  (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Address;Advisory Committees;Affect;Albert Einstein Cancer Center;anti-cancer research;Basic Science;Biological Products;Biology;Cancer Biology;Cancer Burden;cancer care;cancer cell;Cancer Center;Cancer Center Support Grant;cancer epidemiology;Cancer Etiology;cancer health disparity;cancer therapy;career development;Caring;Catchment Area;Characteristics;Chromatin;Clinical;Clinical Informatics;Clinical Research;Clinical Trials;college;Communities;community engagement;Community Outreach;Detection;Diagnostic;Early Diagnosis;Education;education research;Effectiveness;Electronics;epidemiology study;Epigenetic Process;Equilibrium;equity, diversity, and inclusion;ethnic diversity;Face;Faculty;Fostering;Funding;Gender;Genetic;Genetic Transcription;graduate school;health care delivery;Health Professional;Hematologic Neoplasms;high school;Home;Hormonal;Human;human stem cells;Imaging technology;Immunotherapy;Inequity;innovation;interdisciplinary collaboration;Malignant Neoplasms;marginalized community;medical schools;member;Metabolic;Minority;Mission;Modeling;mouse model;NCI Center for Cancer Research;NCI-Designated Cancer Center;Neoplasm Metastasis;next generation;Normal Cell;novel;Obesity;Oncology;outreach;Pathogenesis;Phase;Play;Population Heterogeneity;Population Research;postdoctoral investigator;preclinical study;Prevention;Prevention program;Principal Investigator;Process;programs;Provider;racial diversity;recruit;Research;Research Personnel;Resource Sharing;Resources;Role;Science;Scientist;screening;Services;small molecule;social health determinants;socioeconomics;stem;stem cell biology;Strategic Planning;Therapeutic;Therapeutic Studies;Training;Training and Education;Translating;Translational Research;Translations;tumor microenvironment;tumor progression;Underrepresented Populations;underserved community;Woman

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse

PROJECT_TERMS: Address;Administrative Coordination;Advisory Committees;American;Behavioral Research;Benchmarking;career;career development;Centers of Research Excellence;Cessation of life;Clinical Research;Collaborations;Communication;Data;Dedications;Effectiveness;Ensure;Evaluation;Fostering;Funding;Goals;Growth;Health Policy;Hospitals;improved;Infrastructure;innovation;Lead;Leadership;marginalized population;meetings;Mentors;Mentorship;multidisciplinary;Office of Administrative Management;operation;Opioid;opioid epidemic;opioid overdose;opioid use;opioid use disorder;Overdose;overdose prevention;Pain management;Phase;Pilot Projects;Policies;Prevention;programs;Public Health;recruit;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;research study;Research Support;Rhode Island;Scholarship;Services;Structure;success;symposium;Training;Translating;United States;Vertebral column;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE – TISSUE/HISTOLOGY/IMAGING CORE (CORE B)  The Tissue/Histology/Imaging Core (Core B) is critical for achieving the goals of the UPMC Hillman Cancer Center Head and Neck (HN) SPORE by acquiring and storing biospecimen and patient imaging, processing both and performing of a large variety of cutting-edge analysis techniques to support all HN SPORE projects.

PI_NAMEs: CHIOSEA, SIMION I. (contact)

PROJECT_TERMS: Area;Automobile Driving;Biological;Biological Assay;Blood;Cancer Center;Cancer Patient;central database;Characteristics;Clinical;cluster computing;Collection;Communication;Consent;Coupled;Data;Data Analyses;Data Collection;data exchange;Databases;Dedications;Development;digital;Evaluation;exome sequencing;experience;Flow Cytometry;fluorescence imaging;Free Will;Generations;Genomics;Goals;Head;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Histologic;Histology;Histopathology;Image;Image Analysis;Immunohistochemistry;improved;Individual;Institution;Joints;Laboratories;Link;Malignant neoplasm of thyroid;meetings;multiple omics;nano-string;Organ;Pathologic;Pathologist;Pathology;Patient imaging;Patients;Policies;Preparation;Process;programs;prospective;Proteomics;Publications;radiomics;Raja;recruit;Recurrence;repository;Reproduction spores;Research;Research Personnel;Research Project Grants;Resources;sample collection;Sampling;Scanning;Science;Services;single cell ATAC-seq;single-cell RNA sequencing;Specimen;spectrograph;Squamous cell carcinoma;standard of care;Surgeon;Techniques;Technology;Testing;Tissue Microarray;tissue preparation;Tissues;transcriptome sequencing;transcriptomics;Translational Research;Triage;tumor;tumor-immune system interactions;Work;X-Ray Computed Tomography

PROJECT_TITLE: Core B: Tissue, Histology and Imaging Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Machine Learning and Artificial Intelligence;Rare Diseases

PHR: PROJECT NARRATIVE – BIOSTATISTICS/BIOINFORMATICS CORE (CORE C)  The Biostatistics/Bioinformatics Core (Core C) provides specialized analysis services to the clinical, laboratory, translational and “-omics” research projects of the UPMC Hillman Cancer Center HN SPORE to ensure that experiments are efficiently designed and data are analyzed in a rigorous and reproducible fashion by analysts familiar with cancer in general and head and neck squamous cell carcinoma in particular.

PI_NAMEs: BAO, RIYUE  (contact)

PROJECT_TERMS: Aftercare;Animals;anti-cancer research;Applications Grants;Bayesian learning;Bioinformatics;Biological;Biometry;Cancer Center;career development;Clinic;Clinical;Clinical Cancer Center;Clinical Data;Clinical Protocols;Clinical Research;compare effectiveness;Computer Analysis;Data;Data Analyses;data management;data quality;data quality/integrity;data sharing;design;Development;experience;Experimental Designs;experimental study;Genomics;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Immunohistochemistry;Immunologics;In Vitro;in vivo;Individual;innovation;Laboratories;Machine Learning;Malignant Neoplasms;Manuscripts;member;Methods;multidimensional data;Nature;Patients;Preparation;Program Development;Protocols documentation;Quality Control;Reporting;Reproducibility;Reproduction spores;Research;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Services;Skin Cancer;Specimen;stem;Techniques;Translational Research;translational study;Visualization;Work;Writing

PROJECT_TITLE: Core C: Biostatistics and Bioinformatics Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE – DEVELOPMENTAL RESEARCH PROGRAM (DRP)  The Developmental Research Program (DRP) of the UPMC Hillman Cancer Center HN SPORE seeks to identify, fund and facilitate translationally-driven, diverse, innovative pilot projects in head and neck squamous cell carcinoma through broad solicitation of proposals, vigorous peer-review, and assessment of pilot progress.

PI_NAMEs: NILSEN, MARCI LEE  (contact)

PROJECT_TERMS: Annual Reports;Area;Award;Black race;Cancer Center;Cessation of life;Clinical;Clinical Trials;Collaborations;Databases;Development;disability;Early Diagnosis;Electronic Mail;Eligibility Determination;Ensure;experience;Extramural Activities;Feedback;Fostering;Funding;Goals;Grant;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Historically Black Colleges and Universities;Image;innovation;Institution;inter-institutional;invention;Investments;Legal patent;Link;medical schools;meetings;member;Mentors;Monitor;Morbidity - disease rate;mortality;novel;Organ;outreach;Pathology;Patients;Peer Review;Pilot Projects;predictive marker;Prevention;Process;Prognostic Marker;Program Research Project Grants;programs;Publications;recruit;Reproduction spores;Research;Research Personnel;Resources;Sampling;Scientist;Sister;skills;stem;therapy resistant;translational impact;tumorigenesis;Underrepresented Minority;United States National Institutes of Health;Universities;Update;web site;Woman;Work

PROJECT_TITLE: Developmental Research Program


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Dystonia;Neurodegenerative;Neurosciences;Rare Diseases;Rehabilitation

ORG_CITY: DALLAS

ORG_DEPT: PEDIATRICS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Dystonia is a movement disorder in which muscles twist and contort, forcing patients into painful and disabling postures and abnormal positions. The brain changes that lead to dystonia are largely unknown, but may result from failure of inhibitory mechanisms to keep muscle activity in check. We will perform brain MRI scans to identify the structural changes associated with dystonia, which is an essential step to developing more and better treatments for this disabling movement disorder.

PI_NAMEs: WAUGH, JEFFREY L. (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Absenteeism at work;Adolescent;Adult;Affect;Agonist;Anatomy;Animals;antagonist;Assessment tool;Award;base;Behavior;Biometry;Brain;brain abnormalities;brain based;Brain Injuries;brain magnetic resonance imaging;Brain region;career;Cerebral Palsy;Cervical;Cervical Dystonia;Child;chronic pain;Clinical;cohort;Contralateral;Corpus Callosum;Corpus striatum structure;Deep Brain Stimulation;Diffusion;Diffusion Magnetic Resonance Imaging;disability;Disabling;Disease;Disinhibition;Dystonia;Electrophysiology (science);Ensure;environmental enrichment for laboratory animals;Experimental Designs;Failure;Foundations;Functional Magnetic Resonance Imaging;Globus Pallidus;Goals;Graph;Human;Image;Impairment;improved;Individual;Inherited;Intervention;Ipsilateral;K-Series Research Career Programs;Knowledge;Limb Dystonia;Limb structure;Link;Magnetic Resonance Imaging;Mentors;Methods;Mission;Modeling;Motor;Motor Activity;motor control;Motor Cortex;Motor output;Movement;Movement Disorders;MRI Scans;Muscle;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neuroanatomy;neuroimaging;neuromechanism;neuropathology;Neurosciences;novel;novel therapeutics;Operative Surgical Procedures;Pain;Parkinson Disease;Pathway Analysis;Patient Selection;Patients;Pattern;Persons;Pharmaceutical Preparations;Population;Positioning Attribute;Posture;Prevention;Principal Component Analysis;Regimen;Research;Research Personnel;Rest;Role;Schools;segregation;sensory cortex;sensory feedback;sensory mechanism;Side;Signal Transduction;Site;skills;Source;source localization;Spasm;striosome;Stroke;Structural defect;Structure;Symptoms;Syndrome;System;Techniques;Thalamic structure;Tissues;tool;tractography;Training;Training and Education;Withdrawal;Work

PROJECT_TITLE: The structural underpinnings of disinhibition in dystonia

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Data Science;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

PI_NAMEs: MARSHALL, BRANDON DAVID LEWIS (contact)

PROJECT_TERMS: Acceleration;Address;Biometry;career development;Centers of Research Excellence;Clinical;Clinical Trials;Code;Cohort Studies;Collaborations;Communities;Computer software;computerized tools;Consultations;dashboard;Data;data exchange;data harmonization;Data Linkages;Data Management Resources;Data Security;Data Set;data sharing;Data Storage and Retrieval;data visualization;Databases;design;Development;Educational workshop;Environment;Epidemiologic Methods;Epidemiology;Ethnic Origin;Evaluation;experience;Fostering;Foundations;Funding;Goals;health equity;Health Insurance Portability and Accountability Act;High Performance Computing;Hospitals;Infrastructure;Intervention;Language;Leadership;Maps;member;Methodology;Methods;model building;Modeling;open data;Opioid;opioid epidemic;opioid use disorder;Outcome;Outcome Assessment;Output;Overdose;overdose death;Phase;Play;Policies;population based;Procedures;Process;Public Health;public health intervention;Race;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;research to practice;Research Training;Resources;Sampling;Secure;Services;simulation;software infrastructure;spatial epidemiology;Specific qualifier value;Statistical Data Interpretation;Statistical Models;success;surveillance data;Surveys;sustainable resource;Technology;Time;tool;Training;training opportunity;Translations;Twin Multiple Birth;United States National Institutes of Health;Universities;uptake;user-friendly;Visualization;Work

PROJECT_TITLE: Core B: Data and Research Methods


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rare Diseases

PHR: PROJECT NARRATIVE – CAREER ENHANCEMENT PROGRAM (CEP)  The Hillman Cancer Center HN SPORE Career Enhancement Program (CEP) is designed to foster the growth of a new, diverse generation of diverse scientists dedicated to head and neck squamous cell carcinoma (HNSCC) research leading to improvements in the prevention, detection, and therapy of this deadly disease. To accomplish this, we have established collaborations with Johns Hopkins, Howard University, Emory University and Meharry Medical College to increase the representation of underrepresented minorities in the HN SPORE, in addition to several internal initiatives to increase the diversity of the CEP to the benefit of the entire HNSCC research community.

PI_NAMEs: BAKKENIST, CHRISTOPHER J. (contact)

PROJECT_TERMS: Address;Advisory Committees;Applications Grants;Attention;Award;Basic Science;Cancer Center;career;career development;career preparation;Certification;Clinical;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;Dedications;design;Detection;Development;disability;Disease;Education;education research;Educational Curriculum;Educational workshop;Electronic Mail;Ensure;Environment;experience;Extramural Activities;Faculty;Feedback;Female;Financial Support;follow-up;Fostering;Funding;Future;Gender Issues;Generations;Goals;Grant;Growth;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Health Sciences;Home;improved;Infrastructure;Institution;Malignant Neoplasms;medical schools;meetings;member;Mentors;Mentorship;Mission;next generation;Oral;Peer Review;Performance;Positioning Attribute;Prevention;Process;Program Development;programs;Publishing;recruit;Reporting;Reproduction spores;Request for Applications;Research;Research Personnel;Research Project Grants;responsible research conduct;Science;Scientist;Secure;skills;Study Section;success;Training;Training Programs;Translational Research;translational scientist;Underrepresented Minority;United States National Institutes of Health;Universities;web site;Woman;women faculty;Women's study;Writing

PROJECT_TITLE: Career Enhancement Program


ADMINISTERING_IC: MH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Mental Health;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE Scale-up of HIV preexposure prophylaxis (PrEP) is a key strategy of the U.S. initiative to end the HIV epidemic, but healthcare providers lack tools to support PrEP discussions and prescribing for the patients most likely to benefit. This research will evaluate whether integrating automated tools into electronic health records to help providers efficiently and equitably identify potential candidates for PrEP, discuss PrEP, and prescribe PrEP can improve PrEP initiation and persistence in safety-net community health centers.

PI_NAMEs: KRAKOWER, DOUGLAS SCOTT;MARCUS, JULIA L. (contact)

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Area Under Curve;artificial intelligence algorithm;Black race;California;candidate identification;care delivery;Caring;cis-female;Clinical;clinical decision support;Clinical Informatics;Cluster randomized trial;Code;Community Health Networks;Counseling;Cultural Sensitivity;Data;Diagnosis;digital health;Disparity population;disparity reduction;Dose;electronic health data;Electronic Health Record;Epidemic;Equity;ethnic disparity;ethnic diversity;ethnic minority;Face;Familiarity;follow-up;Formulation;gender disparity;General Practices;Guidelines;Health Personnel;Health system;Healthcare Systems;HIV;HIV diagnosis;HIV Infections;HIV risk;implicit bias;improved;Incidence;Individual;innovation;Intervention;Interview;Laboratories;Language;Latina;Latino;Latinx;Machine Learning;Massachusetts;men who have sex with men;Methods;Modeling;Monitor;Neighborhood Health Center;patient oriented;patient population;Patient Selection;Patients;Perception;Performance;Persons;Play;Population;population health;Poverty;pre-exposure prophylaxis;Predictive Analytics;predictive modeling;Provider;provider intervention;Qualitative Methods;Race;racial disparity;racial diversity;racial minority;racial minority population;Randomized;Research;Resources;Risk;Risk Factors;Role;safety net;scale up;Sex Behavior;Sexuality;Sexually Transmitted Diseases;substance use;Support System;support tools;Testing;tool;Underserved Population;Uninsured;United States National Institutes of Health;uptake;Visit

PROJECT_TITLE: Predictive Analytics and Clinical Decision Support to Improve PrEP Prescribing in Community Health Centers (PrEDICT)

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Cancer

PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward  CANCER CENTER ADMINISTRATION - PROJECT NARRATIVE  Per PAR-21-321, a Project Narrative is not required for this Component.  OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PI_NAMEs: HACKETT, LAUREN E (contact)

PROJECT_TERMS: Administrative Efficiency;analytical tool;anti-cancer research;Award;Awareness;Basic Science;Budgets;Cancer Burden;Cancer Center;Cancer Center Support Grant;Caregivers;Caring;Catchment Area;Clinical Research;Clinical Trials;Collaborations;college;Communication;Communities;community engagement;Community Outreach;dashboard;Data Analytics;data platform;Data Reporting;Decision Making;Early Therapeutic-Clinical Trials Network;Education;Education and Outreach;Ensure;Equipment;equity, diversity, and inclusion;Evaluation;Event;Face;Faculty Recruitment;Fostering;Goals;Grant;health data;Human Resources;Inequity;Informatics;Infrastructure;innovation;Institution;Institutional Policy;Investments;Lead;Leadership;Malignant Neoplasms;Marketing;Medicine;meetings;Mentors;Mission;operation;Operations Research;outreach;Patient advocacy;Patients;Phase;Pilot Projects;Policies;Population Research;Principal Investigator;Process;programs;Recommendation;recruit;Reporting;Research;Research Personnel;Resource Sharing;Resources;Science;social health determinants;stem;Strategic Planning;Structure;success;Time;tool;Training and Education;Translational Research;translational research program;underserved community;web site;Work;working group

PROJECT_TITLE: Administration


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

PI_NAMEs: GREEN, TRACI C (contact)

PROJECT_TERMS: Accidents;addiction;Address;Adult;Affect;Area;Behavior;Behavior Therapy;Behavioral;bench to bedside;career;Caring;Centers of Research Excellence;Cessation of life;Clinical Sciences;Collaborations;Communication;Communities;Complement;Complex;Conflict (Psychology);Consultations;Data;Data Analyses;Data Collection;design;Development;Dissemination and Implementation;Educational workshop;Equipment;Event;Evidence based practice;experience;field study;forging;Foundations;Funding;Goals;Growth and Development function;hackathon;Healthcare Systems;Hospitals;Illicit Drugs;innovation;Institution;Interdisciplinary Study;Intervention;Laboratories;Language;Leadership;literacy;meetings;member;Mentors;Mentorship;Morbidity - disease rate;mortality;Neighborhoods;novel;Opiate Addiction;Opioid;opioid epidemic;opioid overdose;opioid use;opioid use disorder;Overdose;Paper;Patients;Peer Review;Pharmaceutical Preparations;Policies;Policy Maker;Prevention;Process;Productivity;Protocols documentation;Publications;Publishing;Qualitative Research;Records;Research;Research Personnel;Research Project Grants;research study;research to practice;Resources;Rhode Island;Risk;Sampling;Schools;Science;Scientist;simulation;skill acquisition;social;social media;Social Sciences;Solid;Technology;Testing;theories;therapy development;Time;tool;Training;Translating;translational approach;Translational Research;Translations;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;Universities;usability;virtual;Vulnerable Populations;War;web site;Work;Writing

PROJECT_TITLE: Core C: Translational and Transformative Research


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Blinding diseases result from the loss of retinal neurons, thus, strategies to replace lost retinal cells are needed to restore vision to patients. Retinal stem cells responsible for repair in regenerative species, such as fish, appear to retain regenerative potential in humans but remain dormant under normal conditions. We have shown that the immune system regulates retinal stem cell regenerative potential, and propose to determine the impact of disease-relevant aspects of retinal cell death on immune cell reactivity and how this regulates the nature of the regenerative process, providing insights which will support the development of regenerative therapies.

PI_NAMEs: MUMM, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Ablation;Acute;Address;Adult;Bioinformatics;Cell Death;cell type;Cells;Cone;CRISPR/Cas technology;Data;Development;Disease;experimental study;Fatty acid glycerol esters;Feedback;Fishes;gene network;Genes;Genetic;Genetic screening method;glial activation;Goals;Histology;Human;Image;Immune;Immune system;immunoregulation;Immunosuppression;improved;In Vitro;in vivo;in vivo imaging;Injury;Innate Immune System;insight;Kinetics;Label;Larva;Link;Mammals;mathematical model;Methodology;Methods;Microglia;Modeling;Molecular;Natural regeneration;Nature;novel;Outcome;Patients;Photoreceptors;Play;Process;progenitor;programs;Publishing;regeneration potential;regenerative;Regenerative capacity;regenerative therapy;Regulation;repaired;Resources;Retina;Retinal Cone;Retinal Ganglion Cells;retinal neuron;retinal progenitor cell;retinal regeneration;Role;Shapes;sight restoration;Specificity;stem cell fate;stem cell niche;stem cell proliferation;stem cells;System;Testing;Therapeutic;Time;Titrations;transcriptomics;Transgenic Organisms;Vision;Vision Disorders;Zebrafish

PROJECT_TITLE: Innate immune system regulation of retinal regeneration

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics

ORG_CITY: PORTLAND

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Metastatic disease is the primary cause of cancer morbidity and mortality, accounting for more than 90% of cancer-related deaths, yet the molecular mechanisms underlying neoplastic cell metastasis remains poorly understood. The proposed research, herein, will integrate single cell RNA sequencing, novel methods of cyclic immunofluorescence, and cell-based mechanistic studies to identify how discrete subtypes of neoplastic cells, defined by co-expression of immune and tumor characteristics, disseminate in patients with colorectal cancer. Identification and validation of these mechanisms will contribute to our understanding of tumor progression and the development of metastatic disease, with the potential to uncover therapeutic targets aimed to prevent or reduce neoplastic cell dissemination.

PI_NAMEs: ANDERSON, ASHLEY NICOLE (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: 3-Dimensional;Accounting;acute myeloid leukemia 1 protein;Behavior;burden of illness;Cancer Biology;Cancer Etiology;cancer type;career;Cell Culture Techniques;Cell fusion;cell motility;Cell Separation;Cells;Cessation of life;Characteristics;Circulation;Colorectal Cancer;Data;Development;Disease;Distant;early detection biomarkers;Epigenetic Process;epithelial to mesenchymal transition;Evaluation;Evolution;Exhibits;Foundations;Future;Gene Expression;Gene Expression Profile;Genes;Genotype;Goals;hematopoietic stem cell differentiation;Heterogeneity;Hybrid Cells;hybrid gene;Hybrids;Immune;Immune Tolerance;Immunofluorescence Immunologic;improved;In Vitro;in vivo evaluation;in vivo Model;innovation;Institution;Invaded;Investigation;Knock-out;Knowledge;Label;Laboratories;Large Intestine Carcinoma;live cell imaging;lymphatic vessel;Macrophage;Malignant Neoplasms;Mediating;Medical;Meditation;Methods;migration;Migration Assay;Molecular;Monitor;Morbidity - disease rate;mortality;mRNA Differential Displays;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic;neoplastic cell;novel;Organ;Pathway interactions;Patients;Periodicity;peripheral blood;peripheral blood vessel;Phenotype;Physicians;Population;prevent;Primary Neoplasm;Property;protein expression;Research;Research Proposals;Role;Sampling;Scientist;single-cell RNA sequencing;Site;spheroids;System;therapeutic target;Tissue-Specific Gene Expression;Training;transcription factor;translational oncology;tumor;tumor microenvironment;tumor progression;Tumor-Derived;Validation;Work;Xenograft procedure;Zebrafish

PROJECT_TITLE: Mechanisms of Neoplastic Hybrid Cell Dissemination in Colorectal Cancer


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Substance Misuse

PI_NAMEs: BECKWITH, CURT G (contact)

PROJECT_TERMS: Address;Applications Grants;Area;Attention;Behavioral Research;Black race;Centers of Research Excellence;Clinical;Clinical Research;Color;Communities;community advisory board;community empowerment;community engaged research;community engagement;community organizations;community partners;Consultations;COVID-19 pandemic;Data Collection;Drug user;Educational workshop;Environment;Ethics;Failure;fentanyl test;Funding;Future;Goals;Harm Reduction;Health;health disparity;Healthcare;Hospitals;Human Subject Research;Indigenous;Institution;Institutional Review Boards;Lived experience;marginalized community;Mentors;Mission;Names;Opioid;opioid epidemic;opioid use disorder;Overdose;overdose death;Participant;Persons;Pharmaceutical Preparations;Phase;recruit;Reproducibility;Research;Research Activity;Research Design;Research Ethics;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Rhode Island;Role;Services;skills;Special Population;Substance Use Disorder;Technology;test strip;Training;Translational Research;Trauma;underserved community;Underserved Population;United States National Institutes of Health;vulnerable community;Vulnerable Populations

PROJECT_TITLE: Core D: Special Populations


PI_NAMEs: BRESNICK, ANNE R (contact)

PROJECT_TERMS: Advisory Committees;anti-cancer research;Award;Cancer Center Support Grant;cancer education;career;career development;Career Exploration;Catchment Area;college;Communication;community engagement;Community Health Education;Community Outreach;Community Physician;Databases;Detection;Development;Disease;Education;Educational Activities;Educational workshop;Effectiveness;Ensure;equity, diversity, and inclusion;Extramural Activities;Faculty;Female;Fostering;Funding;gender equality;graduate student;Grant;Guidelines;Health Personnel;high school;High School Student;Hispanic;innovation;Institution;interest;Leadership;Logistics;Malignant Neoplasms;Medical Students;meetings;member;Mentors;Mentorship;Mission;next generation;Outcome;Postdoctoral Fellow;pre-doctoral;Prevention;Principal Investigator;Process;programs;recruit;Research;Research Activity;Research Personnel;Research Support;skill acquisition;Students;Training;Training Activity;Training and Education;Travel;undergraduate student;Underrepresented Populations;Woman

PROJECT_TITLE: Cancer Research Training and Education Coordination


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Electronic Nicotine Delivery Systems;Pediatric;Prevention;Substance Misuse;Substance Misuse Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Use of e-cigarettes has dramatically increased among adolescents; however, few prevention programs focusing on prevention and escalation of e-cigarettes have been developed, tested, or widely disseminated throughout the U.S. We have developed a novel Be Vape-Free school-based curriculum aimed at changing high school students’ attitudes towards, misperceptions about, intentions to use and actual use of e-cigarettes, which will be evaluated for changes in adolescents’ knowledge, attitudes, intentions and actual use.

PI_NAMEs: HALPERN-FELSHER, BONNIE L (contact)

PROGRAM_OFFICER_NAME: MAYNE, RACHEL G

PROJECT_TERMS: acceptability and feasibility;addiction liability;Address;Adolescent;adolescent health;Age;aged;Attitude;Behavior;Behavioral Model;Brain;California;cigarette smoking;Cluster randomized trial;combustible cigarette;community based participatory research;community partners;Data;design;Dissemination and Implementation;Education;Educational Curriculum;Effectiveness;efficacy testing;Electronic cigarette;electronic cigarette use;Ethnic Origin;Evaluation;Exposure to;follow-up;future implementation;Health;Health education;Heart;high school;High School Student;improved;interest;intervention effect;Interview;Knowledge;Link;Lung;Marijuana;Marketing;Mental Depression;Mental Health;Middle School Student;Modeling;Nicotine Dependence;novel;optimism;Outcome;Participant;peer;Persons;physical conditioning;pilot test;Planning Theory;positive youth development;prevent;Prevention;Prevention program;programs;Property;Race;random forest;Randomized;Reporting;Research;Resistance;Resources;Schools;skills;social media;Socioeconomic Status;stress reduction;Students;Surveys;teacher;Testing;theories;therapy development;Tobacco;tobacco prevention;Tobacco use;tool;treatment arm;treatment effect;United States;United States National Institutes of Health;vaping;Youth

PROJECT_TITLE: Evaluation of the Be Vape Free Curriculum of the Tobacco Prevention Toolkit


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative The brain’s neural circuitry (connectome), which underlies behavior and presumably goes awry in disorders of the nervous system, is largely unexplored in mammals. The proposed project aims to produce a large-scale connectome that includes all the main areas of the mouse hippocampal formation. This region is of clinical interest because it is an essential part of the circuit underlying spatial navigation and memory and the earliest impairments and degeneration related to Alzheimer’s disease. the site of

PI_NAMEs: LICHTMAN, JEFF W (contact)

PROGRAM_OFFICER_NAME: TALLEY, EDMUND M

PROJECT_TERMS: 3-Dimensional;Alzheimer's Disease;Area;Atlases;Behavior;Blood Vessels;Brain;Brain Mapping;Brain region;Categories;cell type;Cells;Chemical Synapse;Classification;Clinical;cloud storage;Cognition;cohort;Communities;Computer software;computerized data processing;computerized tools;connectome;connectome data;cost;Custom;Data;data acquisition;Data Collection;data management;Data Set;denoising;Devices;Electron Microscope;Electron Microscopy;Electrophysiology (science);Elements;Episodic memory;experience;Face;Gene Expression;Geometry;Goals;Hippocampal Formation;Hippocampus;Human;Image;Image Compression;image processing;imaging system;Imaging Techniques;Impairment;improved;In Vitro;Infrastructure;innovation;interest;Invertebrates;Ions;Label;Language;large datasets;Light;light microscopy;Literature;Location;Mammals;member;Memory;Mental disorders;Mentors;Methods;microCT;Microscope;Microscopic;microscopic imaging;Microtomy;millimeter;Modeling;Molecular Analysis;Monitor;Morphology;Mus;Myelin;Nervous System Disorder;neural circuit;Neuroglia;Neurons;Optics;outreach;patch sequencing;Pathway Analysis;Performance;petabyte;Phase;Physiological;postsynaptic;presynaptic;process improvement;programs;Property;reconstruction;Research;Research Personnel;Resolution;Resources;Sampling;scale up;Scanning;Scanning Electron Microscopy;Science;self supervised learning;Semantics;Site;Slice;spatial memory;Speed;Stains;Stream;Structure;Synapses;System;Testing;Thinness;Tissues;tomography;tool;transcriptome;transcriptomics;undergraduate student;Visualization;way finding;Work;X-Ray Computed Tomography

PROJECT_TITLE: BRAIN CONNECTS: A Center for High-throughput Integrative Mouse Connectomics


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward PLAN TO ENHANCE DIVERSITY - PROJECT NARRATIVE Per PAR-21-321, a Project Narrative is not required for this Component. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PI_NAMEs: ADEDIMEJI, ADEBOLA  (contact)

PROJECT_TERMS: access disparities;anti-cancer research;Behavior;Cancer Center;Cancer Center Support Grant;cancer epidemiology;care delivery;career life balance;Catchment Area;Chronic Disease;Clinical;clinical care;Clinical Services;Clinical Trials;Collaborations;Communicable Diseases;Communities;community engagement;Community Outreach;Data;demographics;Disparity;Education;Ensure;Environment;Equity;equity, diversity, and inclusion;ethnic discrimination;ethnic minority;Ethnic Origin;Evaluation;experience;Extramural Activities;Faculty;Fostering;Gender;Goals;Grant;Health;Health Sciences;Heart;improved;Incidence;Individual;Individual Differences;Infrastructure;Institution;Intervention;Investments;Knowledge;Leadership;life span;Malignant Neoplasms;member;Mentorship;Methods;Mission;Modeling;Monitor;NCI Center for Cancer Research;NCI-Designated Cancer Center;Outcome;Population;Poverty;Prevention;Principal Investigator;Process;programs;Race;racial discrimination;racial minority;Religion;Research;Resources;role model;Scientific Advances and Accomplishments;Scientist;Service setting;Sex Discrimination;Sex Orientation;Training;Training and Education;Underrepresented Populations;United States National Institutes of Health;Vision;Woman;Work;Workplace

PROJECT_TITLE: Plan to Enhance Diversity


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Lung;Nutrition;Obesity;Prevention

ORG_CITY: Chicago

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Poor diet quality is an important risk factor for increased asthma prevalence and poor asthma control. To address the question whether adults with asthma can benefit from following a healthy diet, this project will study a behavioral intervention promoting the Dietary Approaches to Stop Hypertension (DASH) among racially/ethnically and socioeconomically diverse patients with uncontrolled asthma. This study has high potential to advance asthma care by improving our understanding of the role of diet quality in asthma.

PI_NAMEs: MA, JUN  (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: acceptability and feasibility;Acetates;adaptive immunity;Address;Adult;Affect;Age;Airway Disease;airway inflammation;American Lung Association;Area;arm;Asthma;asthma exacerbation;atopy;Behavior Therapy;Behavioral;Biological;Biological Markers;Blood Pressure;Body Weight Changes;Body Weight decreased;Bronchodilator Agents;Butyrates;Calories;Cardiometabolic Disease;Caring;Carotenoids;Cell Physiology;Chicago;chronic inflammatory disease;Clinical;Clinical Trials;clinically significant;Cohort Studies;Counseling;cytokine;DASH diet;Data;Diet;dietary;dietary guidelines;Dietary Practices;Disease;disorder control;disorder prevention;Education;efficacy evaluation;efficacy trial;Enrollment;Environment;Ethnic Origin;Evaluation;Food;Frequencies;fruits and vegetables;Goals;good diet;group intervention;Health;Health education;health related quality of life;Hour;IL17 gene;IL8 gene;Immune;Immune response;Immunologics;improved;indexing;Inflammatory;insight;Intake;Interferon Type II;Interleukin-1 beta;Interleukin-10;Interleukin-5;Interleukin-6;Intervention;intervention effect;intervention participants;Intervention Trial;Length;Link;lung health;Measures;Mediation;Mental Health;metabolomics;Modification;Names;National Heart, Lung, and Blood Institute;Natural Immunity;novel;Nutrient;Nutritional;Obesity;Outcome;Participant;patient oriented;Patient Self-Report;Patients;Phase;Physiological;Pilot Projects;pilot trial;Policies;Preparation;Prevalence;primary outcome;Procedures;Process;Production;Property;Propionates;Protocols documentation;Publishing;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Quality of life;Questionnaires;Race;Randomized;randomized, clinical trials;Recommendation;Reporting;Research;Research Priority;response;Risk;Risk Factors;Role;secondary outcome;Serum;sex;sleep health;socioeconomics;Solid;Structure;Symptoms;systemic inflammatory response;Therapeutic;TNF gene;Training;Treatment Efficacy;trend;trial planning;Unhealthy Diet;United States;Volatile Fatty Acids;weight maintenance;western diet;Wood material;Work

PROJECT_TITLE: The ALOHA trial: Addressing Quality of Life, Clinical Outcomes, and Mechanisms in Uncontrolled Asthma Following the DASH Dietary Pattern

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(MA)]


NIH_SPENDING_CATS: Anxiety Disorders;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Mental Health;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Substance Misuse

PI_NAMEs: WEISS, NICOLE HOLLAND (contact)

PROJECT_TERMS: Biometry;Centers of Research Excellence;Community Integration;community reintegration;contextual factors;Coupled;Data;Ecological momentary assessment;Environmental Monitoring;evidence base;Galvanic Skin Response;Health;heart rate variability;high risk;Hour;Individual;innovation;Inpatients;Life;Methods;Opioid;opioid use;opioid use disorder;Overdose;Persons;Physiology;Post-Traumatic Stress Disorders;prevent;preventive intervention;Research;return to use;Risk;Severities;Symptoms;Testing;Time;tool;wearable sensor technology;Work

PROJECT_TITLE: Prediction of Return to Opioid Use During Immediate Community Reintegration


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Opioids;Pain Research;Physical Injury - Accidents and Adverse Effects

PI_NAMEs: BERNSTEIN, MICHAEL HARRISON (contact)

PROJECT_TERMS: active method;Adult;Advertising;American;arm;Black Box;Cellular Phone;Centers of Research Excellence;chronic pain;chronic pain management;chronic pain patient;chronic painful condition;Clinical;Clinical Research;Clinical Trials;comparison control;Computers;Control Groups;cost;Deception;design;Elements;Esthesia;Etiology;evidence base;follow-up;Helping to End Addiction Long-term;improved;Instruction;Intervention;Measures;Meta-Analysis;milligram;mindfulness;Modeling;Morphine;Nature;non-opioid analgesic;open label;Opioid;opioid epidemic;opioid mortality;opioid use;Outcome;Outcome Study;Overdose;Pain;pain catastrophizing;Pain intensity;Pain interference;Pain management;pain outcome;Participant;participant enrollment;Patients;Personality Traits;Pharmaceutical Preparations;pill;Placebo Effect;Placebos;Play;Population;prescription opioid;primary outcome;Provider;Public Health;Publishing;Questionnaires;Randomized;randomized, clinical trials;recruit;reduce symptoms;Research;Research Personnel;Role;secondary outcome;Teleconferences;Testing;treatment as usual;treatment effect;United States;verbal;Videoconferencing;Visualization;Work

PROJECT_TITLE: Optimizing open placebos for chronic pain patients


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_DEPT: PATHOLOGY

PHR: Project Narrative This application is a renewal of our T32 training program, Opportunities for Pathology Trainees In Cancer research (OPTIC), which supports postdoctoral trainees developing research-oriented careers in cancer pathology. The program is open to a highly select group of clinical trainees, allowing them to conduct in-depth laboratory projects and participate in educational activities geared towards preparing them for leadership roles in academic pathology and laboratory-based cancer research.

PI_NAMEs: ANDERS, ROBERT A. (contact);EBERHART, CHARLES G

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: anti-cancer research;Pathology

PROJECT_TITLE: Opportunities for Pathology Trainees in Cancer Research

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Precision Medicine;Rare Diseases;Women's Health Research

PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward  TUMOR MICROENVIRONMENT AND METASTASES PROGRAM - PROJECT NARRATIVE  Per PAR-21-321, a Project Narrative is not required for this Component.  OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PI_NAMEs: AGUIRRE-GHISO, JULIO A. (contact)

PROJECT_TERMS: Acceleration;Address;Aging;Antineoplastic Agents;Basic Science;Biochemical;Biological Markers;Biological Models;Biology;Breast;Breast Cancer Risk Factor;Cancer Biology;cancer cell;Cancer Center Support Grant;cancer epidemiology;Cancer Patient;Catchment Area;Cell Survival;Cells;chemotherapy;Clinical;Clinical Markers;clinically relevant;Collaborations;Communities;Development;Diabetes Mellitus;Disease;Disseminated Malignant Neoplasm;Education;epidemiologic data;Epigenetic Process;Extravasation;Fostering;Genetic;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;hormone therapy;Human;imaging modality;Imaging technology;Immune;Immunofluorescence Immunologic;Immunotherapy;in vivo;Individual;innovation;insight;Institution;intravital imaging;Knowledge;Life Style;Lung;Magnetic Resonance Imaging;Malignant Neoplasms;Melanoma;Metastatic breast cancer;Metastatic/Recurrent;multi-photon;Multiple Myeloma;Mus;Neoplasm Metastasis;neoplastic cell;new therapeutic target;New York;novel;Oncology Group;Organ;Organoids;Output;Pathology;Pathway interactions;Patient Care;personalized medicine;Positioning Attribute;Predisposition;Prevention;Principal Investigator;programs;Prostate;Recurrence;Relapse;relapse prevention;Research;Research Personnel;Residual Neoplasm;Resistance;Resolution;Science;Signal Transduction;Site;stem;stem cell biology;Systemic Therapy;targeted agent;Technology;Therapeutic;therapeutic biomarker;Tissues;Translating;translational potential;tumor microenvironment;Vision;Zebrafish

PROJECT_TITLE: Tumor Microenvironment and Metastasis Program


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Bioengineering

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Narrative The research proposes to use dynamic nuclear polarization (DNP) to improve the sensitivity in magic angle spinning NMR experiments that will lead to molecular structures with higher precision. In particular, we propose to apply high frequency DNP to familial amyloid systems whose structure we will determine and to high-resolution multidimensional 17O experiments. We will develop instrumentation for the experiments, and new time domain methods for more rapid data acquisition and we believe that the research will have a profound impact on structural biology, medical imaging and solution NMR.

PI_NAMEs: GRIFFIN, ROBERT GUY (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Amino Acids;Amplifiers;Amyloid;Amyloid Proteins;Arctic mutation;Area;Biological Models;biological systems;Biophysics;C-terminal;Circulation;cold temperature;Communities;cryogenics;Data;data acquisition;Dependence;design;design and construction;Development;Diameter;Diamond;Dimensions;Drops;Early Onset Alzheimer Disease;Exhibits;experimental study;Frequencies;Gases;Grant;Helium;improved;instrument;instrumentation;Investigation;irradiation;Isotope Labeling;Label;Lasers;Liquid substance;Magic;Magnetic Resonance Imaging;Medical Imaging;method development;Methodology;Methods;microwave electromagnetic radiation;Molecular Structure;mutant;North America;Nuclear;Nuclear Magnetic Resonance;Peptides;Phase;Physiologic pulse;Procedures;Proteins;Research;Resolution;Series;Solid;sound;Speed;Stretching;structural biology;Structure;System;Techniques;Temperature;Time;Translating;waveguide;Work

PROJECT_TITLE: High Field DNP and EPR in Biological Systems

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Cancer;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward  STEM CELL AND CANCER BIOLOGY PROGRAM - PROJECT NARRATIVE  Per PAR-21-321, a Project Narrative is not required for this Component.  OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PI_NAMEs: GRITSMAN, KIRA  (contact)

PROJECT_TERMS: Animal Model;anti-cancer;Basic Science;biobank;Biostatistics Shared Resource;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer stem cell;cancer therapy;Catchment Area;Cell Differentiation process;Cell model;Cells;Clinic;Clinical;Clinical Investigator;clinical translation;Collaborations;college;Credentialing;disease model;Doctor of Philosophy;Epigenetic Process;Evolution;experience;Flow Cytometry Shared Resource;Funding;Genetic Transcription;Genomics Shared Resource;Goals;Hematologic Neoplasms;imaging facilities;Industry;insight;interest;Investigation;KRAS2 gene;leukemia;leukemic stem cell;Malignant - descriptor;Malignant Neoplasms;Medicine;member;Mission;model organism;Molecular;mouse model;Myeloproliferative disease;NCI Center for Cancer Research;new therapeutic target;novel;Physicians;Physiological;Post-Translational Regulation;pre-clinical;preclinical study;Preleukemia;Principal Investigator;programs;recruit;Research;Resistance;Resource Sharing;Science;Scientist;Specific qualifier value;stem;stem cell biology;stem cell function;Therapeutic;Therapeutic Studies;translational applications;Translational Research;translational research program;translational scientist;Translations;tumor progression;Work

PROJECT_TITLE: Stem Cell and Cancer Biology Program


ADMINISTERING_IC: DK

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Esophageal Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: Baltimore

ORG_NAME: CAPSULOMICS, LLC

PHR: Our team has an established history of invention, development, optimization, and validation of a ready-to-launch lab-developed test (LDT), the ENVISAGE assay. This epigenetic biomarker assay predicts future progression risk in patients with Barrett’s esophagus, with 71% sensitivity and 90% specificity. This strong performance for a prognostic assay surpasses any clinical assay currently available. Successful refinement and validation of our proposed 2nd-generation assay will greatly enhance the current repertoire of clinical tools for more precise, efficient, and accurate patient care.

PI_NAMEs: LAUN, SARAH  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Adenocarcinoma;Adoption;Age;Algorithms;Barrett Esophagus;Bioinformatics;Biological Assay;Biological Markers;biomarker panel;Biometry;Biopsy Specimen;Case/Control Studies;Categories;Classification;Clinical;clinical decision-making;Clinical Management;Clinical Research;clinical research site;cohort;Collaborations;commercialization;cost;Data;Development;Diagnosis;diagnostic assay;DNA;DNA Methylation;Dysplasia;Early Diagnosis;Engineering;epigenetic marker;Epigenetic Process;Esophageal Adenocarcinoma;Esophagus;falls;Feedback;Focus Groups;Foundations;Funding;Future;gastrointestinal;Generations;Genes;Guidelines;Health system;Hematoxylin and Eosin Staining Method;High grade dysplasia;high risk;Histologic;Image Analysis;Immunohistochemistry;improved;Incidence;innovation;Interview;invention;Journals;Laboratories;Licensing;Machine Learning;Malignant Neoplasms;Market Research;Marketing;Methylation;Modeling;molecular marker;multimodal modeling;novel;novel marker;Paraffin Tissue;Pathologic;Pathway interactions;Patient Care;patient stratification;Patients;Performance;Phase;phase 1 study;Physicians;Precancerous Conditions;predictive test;Primary Care Physician;processing speed;prognostic assays;progression risk;Protocols documentation;quantitative imaging;Recommendation;Recording of previous events;Risk;Risk Estimate;Risk Factors;risk mitigation;risk prediction;risk stratification;Sensitivity and Specificity;Site;Small Business Innovation Research Grant;Specificity;study population;success;Survival Rate;System;Testing;Time;tissue biomarkers;Tissues;tool;Training;tumor progression;United States;Universities;usability;Validation;validation studies

PROJECT_TITLE: Validation and Early Commercialization of the ENVISAGE Assay, a Prognostic Test for Barrett's Esophagus


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_NAME: MIRIAM HOSPITAL

PHR: PROJECT NARRATIVE The project addresses the problem of weight loss maintenance, one of the most major and critical barriers to the treatment of obesity and comorbid conditions. It is the first to apply control systems engineering, in the form of a system identification experiment, to model how behavioral and psychosocial influences combine to influence weight loss maintenance, and to evaluate the effect of four intervention strategies on the behavioral and psychosocial system. This project will enable a just-in-time adaptive intervention capable of predicting when an individual is entering a period of elevated risk for weight regain, and delivering a tailored intervention targeting the cause of regain to prevent it from occurring.

PI_NAMEs: HEKLER, ERIC ;RIVERA, DANIEL E;THOMAS, JOHN GRAHAM (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: adaptive intervention;Address;Adult;Affect;Algorithms;Area;automated intervention;barrier to care;Behavior;behavior influence;Behavior Therapy;Behavioral;Behavioral Model;Biological Models;Body Weight;Body Weight decreased;Cardiovascular system;Cellular Phone;clinically significant;comorbidity;Complex;cost;Data;design;Desire for food;Disease;dynamic system;Eating;Ecological momentary assessment;Educational process of instructing;effective intervention;Energy Intake;Engineering;experience;experimental study;Future;Generations;Individual;individual patient;Informal Social Control;innovation;Intervention;Maintenance;Malignant Neoplasms;Maps;Mathematics;Measures;mobile computing;Modeling;Monitor;multidisciplinary;obesity treatment;Operative Surgical Procedures;Participant;Patients;Pattern;personalized intervention;Pharmacologic Substance;Phase;physical inactivity;Physiological;prevent;psychosocial;Psychosocial Factor;Psychosocial Influences;Registries;relapse prevention;Research;Research Methodology;Rewards;Risk;Risk Factors;Risk Reduction;Sampling;Severities;Severity of illness;social health determinants;Stressful Event;System;Techniques;Technology;Testing;Theoretical model;theories;Time;Translating;vigilance;Weight;weight maintenance;Weight maintenance regimen;Work

PROJECT_TITLE: Control Systems Engineering to Address the Problem of Weight Loss Maintenance: A System Identification Experiment to Model Behavioral & Psychosocial Factors Measured by Ecological Momentary Assessment


NIH_SPENDING_CATS: Biotechnology;Cancer

PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward  CANCER THERAPEUTICS PROGRAM - PROJECT NARRATIVE  Per PAR-21-321, a Project Narrative is not required for this Component.  OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PI_NAMEs: ALMO, STEVEN C. (contact)

PROJECT_TERMS: anti-cancer research;Antineoplastic Agents;Bioinformatics;Biological Products;Cancer Center;Cancer Center Support Grant;cancer pharmacology;cancer therapy;Cancer Therapy Evaluation Program;Catchment Area;Clinical;clinical development;Clinical Investigator;Clinical Trials;Collaborations;Conduct Clinical Trials;Credentialing;design;Development;Developmental Therapeutics Program;Disease;Disparity;Doctor of Philosophy;drug development;Early Diagnosis;Equity;Goals;Human;improved;innovation;Interdisciplinary Study;interest;Laboratories;Malignant Neoplasms;member;Mentors;Mission;Molecular;NCI Center for Cancer Research;novel;novel anticancer drug;novel therapeutics;Organ;Outcome;Pharmacologic Substance;Phase;pre-clinical;preclinical development;Prevention;Principal Investigator;programs;recruit;Research;Research Personnel;Resistance;Resource Sharing;Science;Scientist;small molecule;Therapeutic;Translating;Translational Research;translational scientist;Translations;Treatment Protocols;tumor;Variant

PROJECT_TITLE: Cancer Therapeutics Program


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Adolescent girls and young women in Kenya are disproportionately affected by poverty and HIV. Economic empowerment is a promising poverty and HIV risk reduction strategy. This project aims to improve how we measure and address economic empowerment in HIV prevention interventions for AGYW.

PI_NAMEs: GICHANE, MARGARET  (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: 19 year old;Address;Adolescent HIV risk;Adult women;Affect;Africa;Age;Age disparity;AIDS prevention;career;cognitive interview;Communities;Data Collection;design;Development;disparity reduction;Doctor of Philosophy;economic determinant;economic impact;Economics;Educational workshop;Effectiveness;empowerment;evidence base;experience;Feedback;Female Adolescents;Focus Groups;Funding;Goals;HIV;HIV diagnosis;HIV risk;Household;improved;Incidence;Income;Individual;Intervention;Investigation;Kenya;Knowledge;learning strategy;Measurement;Measures;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Methods;multidisciplinary;novel;Outcomes Research;Parents;pilot test;Population;post intervention;Poverty;preventive intervention;Principal Investigator;Process;Property;Psychometrics;Public Health;Qualitative Research;Research;Research Personnel;Research Priority;Resources;Risk;Risk Behaviors;Risk Reduction;Role;Sampling;Savings;Schools;skills;social determinants;Socioeconomic Status;structural determinants;Testing;theories;therapy development;tool;Training;Transact;transactional sex;transmission process;United States National Institutes of Health;Unsafe Sex;Validation;young woman;Youth

PROJECT_TITLE: Addressing Economic Empowerment to Reduce HIV Risk among Adolescent Girls and Young Women in Kenya


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_CITY: Fort Lauderdale-Davie

ORG_NAME: NOVA SOUTHEASTERN UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative This study will determine the role of Piezo1 expressed on OCs in the context of dysregulated bone remodeling in P. gingivalis-associated periodontitis. Therefore, this study would cause the paradigm shift in research of mechasnosensor and periodontitis. Outcomes from this project will elucidate the effect of Pg on Piezo1- mediated mechanical sensing of OC in periodontitis and develop a novel therapeutic approach to suppress pathogenic bone loss while inducing bone regeneration.

PI_NAMEs: SHINDO, SATORU  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Actinobacillus actinomycetemcomitans;Actins;Address;Affect;Alkaline Phosphatase;alveolar bone;ANXA5 gene;Applications Grants;Awards and Prizes;Binding;Binding Proteins;Biology;Biomedical Research;bone;bone loss;Bone Regeneration;Bone remodeling;Bone Resorption;career development;cathepsin K;Cells;Chemicals;Coculture Techniques;complex data;Consultations;Core Facility;Coupling;Cytochalasin D;Cytoskeleton;Data;Data Set;Development;Devices;dihydroceramide;Down-Regulation;Ensure;Enzyme-Linked Immunosorbent Assay;Equipment;experience;Florida;Forsythia;Foundations;Future;gain of function;Goals;Grant;Image;Immune;immunopathology;improved;In Vitro;in vivo imaging;Inflammatory Response;inhibitor;Insulin-Like Growth Factor I;Interferometry;Laboratories;Laboratory Personnel;Ligature;Link;lipidomics;Lipids;loss of function;Mechanical Stimulation;Mechanical Stress;Mechanics;mechanotransduction;Mediating;Mentors;Methods;Microbiology;microCT;Microscopy;Molecular;Monitor;morphometry;Motor;mouse model;Mus;Mycotoxins;Myosin Type II;neutralizing antibody;Nobel Prize;non-muscle myosin;novel;novel therapeutic intervention;Oral Administration;Osteoblasts;Osteoclasts;Osteocytes;osteoimmunology;Osteoporotic;Outcome;Pathogenicity;Periodontitis;Periodontium;periodontopathogen;Phenotype;Phosphatidylserines;Piezo 1 ion channel;Piezo 2 ion channel;Porphyromonas gingivalis;Postdoctoral Fellow;precursor cell;Process;Production;programs;Proteins;Protocols documentation;Raman Spectrum Analysis;regeneration potential;Reporting;Research;Research Personnel;Research Project Grants;response;Risk Factors;Role;Science;shear stress;Signal Transduction;skills;Small Interfering RNA;System;Systemic disease;Techniques;Testing;Tissues;TNFSF11 gene;Tooth structure;Training;Transferase;Virulence Factors;Virulent;Writing

PROJECT_TITLE: Mechanosensing of osteoclasts in periodontitis.


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Endocrine Disruptors;Genetics;Human Genome;Infectious Diseases;Microbiome;Urologic Diseases

ORG_CITY: Columbus

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Bladder cancer is strongly linked to environmental chemical exposures including polycyclic aromatic hydrocarbons (PAHs), but the mechanisms underlying these links remain unclear, and not all exposed individuals develop bladder cancer. PAHs like benzo[a]pyrene (BaP) are found in automobile exhaust and tobacco smoke, and differential metabolism of these chemicals by host-associated microbes could be a contributing factor to bladder cancer pathogenesis; therefore, the aim of this proposal is to define gut and urine microbial metabolism of BaP and determine how this metabolism affects bladder cells. This work impacts public health by establishing a novel chemical-microbe-host framework for evaluating bladder health within the broader context of bladder cancer development.

PI_NAMEs: HALE, VANESSA L (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Acinetobacter baumannii;Affect;Air;Animal Model;Aromatic Polycyclic Hydrocarbons;Automobile Exhaust;Bacteria;Benzo(a)pyrene;Bladder;Bladder Urothelium;cancer diagnosis;carcinogenesis;carcinogenicity;Cells;chemical safety;Chemicals;Coal;combinatorial;cytotoxic;Development;Disease;Drug Metabolic Detoxication;Engineering;Enterococcus faecalis;Environment;environmental chemical;environmental chemical exposure;Epithelium;Epoxy Compounds;Escherichia coli;estrogenic;Excretory function;Experimental Designs;experimental group;Exposure to;Feces;Female;Food;Foundations;Fusobacterium nucleatum;Gases;Genes;Genome;genotoxicity;gut microbiota;Health;high risk;Homeostasis;host-associated microbial communities;host-microbe interactions;Human;Hydroxylation;Immune response;In Vitro;in vivo;Inbred BALB C Mice;Individual;Inflammation;Ingestion;innovation;insight;Lactobacillus;Link;Maintenance;male;Malignant neoplasm of urinary bladder;Mass Fragmentography;Meta-Analysis;Metabolic;Metabolism;metabolome;metabolomics;Microbe;microbial;microbial community;microbial composition;microbiome;mouse model;Mus;novel;Oils;Outcome;Parents;Pathogenesis;Pathway interactions;Poison;pollutant;Predisposition;Pseudomonas aeruginosa;Public Health;Ralstonia;Reporting;Research;response;Risk Factors;Role;Salvelinus;Sampling;secondary metabolite;sex;Soil;Sphingomonas;System;Taxonomy;Tobacco;Tobacco smoke;Toxic effect;Urinary tract;Urine;Urothelial Cell;Urothelium;Vendor;Water;Work

PROJECT_TITLE: Bladders and biomes: Environmental compounds as modifiers of microbiomes, metabolomes, and urothelium


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Complementary and Integrative Health;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Precision Medicine;Rehabilitation

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative Rotator cuff tears are a common injury in the growing middle-to-late aged population and can cause severe pain, activity limitations and participation restrictions. The proposed research will utilize a large, unique, and previously collected cohort to help establish clinical guidelines for the use of exercise therapy as the initial treatment for rotator cuff tears using quantitative characteristics of their shoulder function. Results will guide the development of individualized treatment plans to improve outcomes while reducing time and expense of care.

PI_NAMEs: DEBSKI, RICHARD E (contact);IRRGANG, JAMES JOHN

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: active lifestyle;Address;Age;aging population;Articular Range of Motion;Back;Bilateral;Biomechanics;Caring;Characteristics;Clinical;cohort;comparison control;Computer Analysis;Computer Models;Control Groups;Data Set;Development;disability;Exercise Therapy;Failure;follow-up;Frequencies;Funding;Guidelines;Hand;Health;improved;improved outcome;in vivo;Incidence;Individual;individualized medicine;Injury;Isometric Exercise;joint function;Joint structure of shoulder region;Joints;kinematics;large datasets;Length;Maintenance;Modeling;muscle strength;Musculoskeletal;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;observational cohort study;Observational Study;Operative Surgical Procedures;optimal treatments;Orthopedics;Outcome;outcome prediction;Pain;Participant;Passive Range of Motion function;Pathology;Patient Outcomes Assessments;Patients;personalized medicine;Persons;physical therapist;programs;prospective;Reaction;reduce symptoms;repaired;Reporting;Research;restoration;Rotation;Rotator Cuff;rotator cuff injury;rotator cuff tear;sex;Shoulder;success;supraspinatus muscle;Surgeon;Symptoms;Tendon structure;Time;Translations;treatment planning;Treatment Protocols;Visit

PROJECT_TITLE: Predicting the Outcome of Exercise Therapy for Treatment of Rotator Cuff Tears

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Cervical Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Lung;Lung Cancer;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health;Women's Health Research

PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward  CANCER EPIDEMIOLOGY, PREVENTION AND CONTROL PROGRAM - PROJECT NARRATIVE  Per PAR-21-321, a Project Narrative is not required for this Component.  OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PI_NAMEs: HOSGOOD, H DEAN  (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Affect;anti-cancer research;Articulation;Back;Behavioral;Biological;Biological Models;Black race;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;cancer epidemiology;Cancer Etiology;cancer health disparity;Cancer Patient;cancer prevention;care delivery;care outcomes;Catchment Area;Cervical Cancer Screening;Clinical;Clinical Data;clinical practice;Collaborations;Communities;community engagement;community involvement;Community Outreach;community setting;County;design;Detection;Development;Disparity;Early Diagnosis;Effectiveness;effectiveness testing;electronic medical record system;Ensure;Epigenetic Process;equity, diversity, and inclusion;Etiology;Evolution;fire fighter;Genetic;Goals;Guidelines;Health;health inequalities;Health Personnel;Health Services Accessibility;Health system;high risk;high risk population;HIV;Home;Human;Human Papillomavirus;improved;Incidence;Individual;Inequity;infection related cancer;innovation;Institution;International;Intervention;Laboratories;Language;Latinx;Leadership;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;member;Mentors;Minority;Mission;Modeling;Molecular;mortality;multiple chronic conditions;Nature;NCI Center for Cancer Research;New York;non-smoker;novel;novel therapeutic intervention;Obesity associated cancer;Organ;Outcome;outreach;Participant;patient retention;Patients;Peer Review;Personal Satisfaction;Persons;Play;Policies;Population;Population Heterogeneity;Population Research;Population Study;Poverty;Predisposition;prevent;Prevention;Principal Investigator;Productivity;programs;psychosocial;Public Health;Public Health Practice;Quality of life;Research;Research Design;Research Personnel;Risk Factors;Role;screening;Shapes;smoking intervention;social;social determinants;social health determinants;Statistical Methods;Strategic Planning;Supportive care;Testing;Tobacco smoking behavior;Training;Translating;Translations;trend;tumor;Variant;virtual;Vulnerable Populations;Western Africa;Work

PROJECT_TITLE: Cancer Epidemiology, Prevention and Control Program


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE To increase physical activity and associated chronic diseases among mothers living in low- resourced communities, innovative research to identify a multilevel intervention that is easily implemented at the community level and appropriate for mothers with little time is urgently needed. This project will use qualitative and quantitative methods in a cluster randomized control trial to evaluate the effectiveness of the Free Time for Wellness(FT4W) program, which includes free childcare at free fitness classes and peer support activities. The trial will evaluate: (1) the ability of FT4W to increase physical activity within 12 weeks as confirmed by accelerometers; (2) the potential mechanisms by which the FT4W program facilitates physical activity (e.g., environmental resources, social cohesion); and (3) potential differences in the magnitude of effect across intersecting social stratification parameters including race/ethnicity, socioeconomic position, and migration status.

PI_NAMEs: HOUGHTON, LAUREN C (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, ANGELA R

PROJECT_TERMS: Accelerometer;Address;Adopted;Adoption;Affect;anti-cancer research;Area;arm;Behavior;care providers;Child;Child Care;Chronic Disease;Communication;Communities;Community Health;community-level factor;Dancing;Day Care;Decision Making;design;disease disparity;Economically Deprived Population;effectiveness evaluation;effectiveness testing;Ethnic Origin;Ethnography;exercise intervention;Family health status;Feasibility Studies;fitness;Food;Funding;Future;Gender Role;Guidelines;Health;Health behavior;Health Disparities Research;health disparity;Height;high risk;improved;Individual;innovation;intersectionality;Intervention;intervention effect;Investments;Low income;low socioeconomic status;Manuscripts;Maternal Health;Measures;Mediating;meetings;Methodology;Methods;migration;Minority;minority health;minority health disparity;Modeling;Moderate Exercise;Mothers;National Cancer Institute;National Institute on Minority Health and Health Disparities;Neighborhoods;new pandemic;New York City;novel;Participant;peer support;Personal Satisfaction;Persons;Physical activity;physical inactivity;Pilot Projects;Play;Population;prevent;Process;programs;Protocols documentation;Publishing;Race;racial minority;Racial Segregation;Randomized;Randomized, Controlled Trials;Recommendation;Recreation;recruit;Research;Resource-limited setting;Resources;Risk;Risk Reduction;social;social cognitive theory;social cohesion;social disparities;Social Network;Social Reinforcement;Social Sciences;Social stratification;socioeconomic disadvantage;Socioeconomic Status;socioeconomics;support network;Support System;Technology;Testing;Text Messaging;theories;therapy design;Time;treatment arm;virtual;Visit;Volunteer Group;Washington;Wellness Program;Woman;Work;Yoga

PROJECT_TITLE: Free Time 4 Wellness

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: CINCINNATI

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project Narrative Swallowing impairments (dysphagia) frequently occur after stroke and have devastating consequences on overall health and quality of life. Long-term deficits in swallow function also increase risk of morbidity (e.g. depression) and mortality (i.e. aspiration pneumonia), as such, rehabilitation of swallow function to improve safety and efficiency of swallowing is essential in this population. This study aims to: 1) Provide preliminary data to evaluate the effect of a novel lingual endurance exercise on swallow function in individuals with post-stroke dysphagia; and 2) Collect preliminary data regarding changes in white matter tract diffusion and cortical thickness and from MRI data to better understand effects of lingual exercise training on neuroplasticity.

PI_NAMEs: KREKELER, BRITTANY NICOLE (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Acute;Anisotropy;aspirate;Aspiration Pneumonia;Award;Barium swallow;career;career development;Clinical;clinical efficacy;Clinical Research;Clinical Trials;Data;Data Set;Deglutition;Deglutition Disorders;design;Development Plans;Diffusion;Diffusion Magnetic Resonance Imaging;endurance exercise;Ensure;Environment;Exercise;exercise training;experience;functional outcomes;Funding;Future;Goals;gray matter;Health;Impairment;improved;Individual;innovation;Institution;Intake;Intervention;Intervention Trial;Ischemic Stroke;K-Series Research Career Programs;Knowledge;Magnetic Resonance Imaging;Measures;Mental Depression;Mentors;Mentorship;Mission;Morbidity - disease rate;mortality;Motor Cortex;Movement;Multi-Institutional Clinical Trial;multidisciplinary;neural;neuroimaging marker;Neuronal Plasticity;Neurosciences;novel;novel strategies;Nutritional;Oral;Oropharyngeal;Oropharyngeal Dysphagia;Outcome;Outcome Measure;patient population;Patients;Penetration;Pharyngeal structure;Phase;phase I trial;Physiology;pilot trial;Population;post stroke;primary outcome;Property;psychosocial wellbeing;Quality of life;Randomized;Randomized, Controlled Trials;Recovery;recruit;rehabilitation research;Rehabilitation therapy;Research;Risk;Safety;secondary outcome;Site;skills;strength training;Stroke;stroke patient;stroke recovery;stroke rehabilitation;Structure;success;Thick;Tongue;Training;training opportunity;Transference;Translating;Translational Research;United States National Institutes of Health;Universities;white matter;Work

PROJECT_TITLE: Impact of Lingual Endurance Exercise on Rehabilitation of Swallowing Impairments after lschemic Stroke

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward  COMMUNITY OUTREACH AND ENGAGEMENT - PROJECT NARRATIVE  Per PAR-21-321, a Project Narrative is not required for this Component.  OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PI_NAMEs: RAPKIN, BRUCE D (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;advocacy organizations;Advocate;Affect;African;Black race;Cancer Burden;cancer care;Cancer Center Support Grant;cancer clinical trial;Cancer Detection;cancer diagnosis;cancer education;cancer health disparity;Cancer health equity;Cancer Patient;Caring;Case Mixes;Catchment Area;Clinic;Clinical;Clinical Trials;Collaborations;Communities;Communities That Care;community advisory board;community engaged approach;community engagement;Community Outreach;community partnership;community planning;County;Data;Decision Making;Disparity;disparity reduction;Doctor of Philosophy;Early Diagnosis;end of life care;Enrollment;Ensure;Equity;Etiology;Faith-based organization;Feedback;fertility preservation;Fostering;Future;Goals;Health;Health care facility;health equity promotion;Health system;healthcare community;Hepatitis B Virus;Hepatitis C co-infection;Hispanic;Housing;Human Papilloma Virus Vaccination;Immigrant;Incidence;innovation;International;Internships;Latinx;Leadership;Learning;Logic;Low income;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;Modeling;Monitor;Needs Assessment;Neighborhoods;new technology;Organizational Culture;Outcome;Outcomes Research;pandemic disease;Patient Participation;Patients;Play;Policies;Population Heterogeneity;Poverty;Prevention;Principal Investigator;Problem Solving;Process;programs;Public Health;Race;Reporting;Research;Role;Schools;screening;service programs;social determinants;social health determinants;Social Work;Specialist;Strategic Planning;success;Supportive care;survivorship;telehealth;Trust;Underrepresented Populations;volunteer;Work

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward  DEVELOPMENTAL FUNDS - PROJECT NARRATIVE  Per PAR-21-321, a Project Narrative is not required for this Component.  OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PI_NAMEs: CHU, EDWARD  (contact)

PROJECT_TERMS: Address;Affect;Aging;Air Pollution;Applications Grants;Articulation;Award;Behavioral;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer epidemiology;cancer health disparity;Capital;Cataloging;Catchment Area;Cell Therapy;Chemoprevention;Clinical Trials;colon cancer prevention;community advisory board;community engagement;Community Outreach;Data;Development;Diagnosis;Disclosure;Doctor of Philosophy;drug development;effective intervention;Environmental Exposure;equity, diversity, and inclusion;Evaluation;Expenditure;Faculty Recruitment;Fostering;Funding;Funding Agency;Funding Mechanisms;Future;Genomic medicine;Goals;Grant;Health;health disparity;Health Services;Health Services Accessibility;Immunotherapy;implementation science;improved;innovation;Institution;interdisciplinary collaboration;invention;investigator-initiated translational research;Investments;Leadership;Legal patent;Licensing;Link;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;member;Modeling;Neoplasm Metastasis;oncofertility;Outcome;patient population;Patients;Peer Review;Phase;Philanthropic Fund;Pilot Projects;pilot trial;precision medicine;Principal Investigator;Prize;Process;programs;Publications;Reporting;Request for Proposals;Research;Research Personnel;research study;Science;Signal Transduction;small molecule;social health determinants;Source;Strategic Planning;targeted agent;Therapeutic;Translational Research;tumor;tumor immunology;tumor microenvironment;Underrepresented Populations;Underserved Population;United States National Institutes of Health

PROJECT_TITLE: Developmental Funds


ED_INST_TYPE: SCHOOLS OF LAW OR CRIMINOLOGY

NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: BOSTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative The goal of the current project is to measure the prevalence of cancer misinformation on social media and understand the mechanisms that underlies its spread. Specifically, it aims to (1) characterize the prevalence of cancer misinformation on social media, namely Twitter and Facebook, (2) investigate how people make judgements of source credibility with regards to disreputable cancer sources, and (3) understand the cognitive mechanisms behind updating belief in cancer misinformation.

PI_NAMEs: SWIRE-THOMPSON, BRIONY  (contact)

PROGRAM_OFFICER_NAME: CHOU, WEN-YING

PROJECT_TERMS: Address;Alternative Medicine;Apricot;Area;Award;Belief;Binding;Cognitive;Communication;computer science;conventional therapy;Cyanides;Data;Dedications;design;Development;distinguished professor;Eating;Ensure;evidence base;Evidence based treatment;Exposure to;Facebook;fictional works;Force of Gravity;Fostering;Friends;General Population;Goals;health communication;Health Professional;heuristics;Human;Individual;Intervention;Knowledge;Lead;Life;Link;Malignant Neoplasms;Measures;medical schools;Mentors;Mind;Misinformation;mortality risk;Mothers;news;Observational Study;Oncologist;Participant;Pathway interactions;Perception;Persons;Phase;Poisoning;Politics;Population;Positioning Attribute;Prevalence;professor;programs;psychologic;Public Health;Public Health Schools;Records;Research;Resistance;Rewards;Sampling;Science;skills;social media;Source;Surveys;Testing;Training;Trust;trustworthiness;Twitter;Universities;Update;Utah

PROJECT_TITLE: Cancer misinformation on social media and its correction

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Contraception/Reproduction;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Usher Syndrome

PHR: PROJECT NARRATIVE This project will create a unique new resource to advance research into cures for blinding diseases by studying a genetic line of rhesus monkeys with a retinal disease mirroring human Bardet-Biedl syndrome, a form of retinitis pigmentosa that is currently untreatable. We will characterize the nature and time course of the disease in these unique animals and use them to test a new type of gene therapy for its ability to preserve and restore vision. Such treatments have the potential to provide sight-saving therapy to human patient with this and many other causes of blindness.

PI_NAMEs: NEURINGER, MARTHA  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: 2 year old;4 year old;Acceleration;Adult;Age Months;Ally;animal breeding;Animal Model;Animals;Area;Artificial Insemination;Assisted Reproductive Technology;attenuation;Bardet-Biedl Syndrome;behavior measurement;Birth;Blindness;Brain;Bulla;causal variant;Characteristics;ciliopathy;Clinical;clinical practice;Collaborations;Cone;cone-rod degeneration;Deafblind;Development;Disease;disease model;DNA Sequence Alteration;Dose;early onset;effective therapy;efficacy testing;Electroretinography;Embryo;Exons;experience;Eye;Family;fovea centralis;gene augmentation therapy;Gene Delivery;gene therapy;Generations;Genes;Genetic;Genetic Diseases;genetic pedigree;Genotype;Goals;Hereditary Disease;Histopathology;Human;Image;Immunohistochemistry;Infant;Inherited;inherited retinal degeneration;Injections;Kidney;Kidney Diseases;Knowledge;Macaca;Macaca mulatta;macula;Methods;Modeling;Monkeys;multimodality;Mutation;Nature;nonhuman primate;novel;novel therapeutics;Obesity;Operative Surgical Procedures;Oregon;Pathogenicity;Pathology;Patients;Phenotype;photoreceptor degeneration;Photoreceptors;pre-clinical;Preclinical Testing;preservation;prevent;Primates;promoter;Reproduction;Reproductive Biology;Research;Resources;Retina;Retinal Degeneration;Retinal Diseases;Retinal gene therapy;retinal imaging;Retinitis Pigmentosa;Rodent;Safety;screening;Serotyping;sight restoration;Site;Structure;Study models;Syndrome;Testing;Therapeutic;Time;translational model;translational potential;Translations;Usher Syndrome;vector;Vision;vision development;Visual;Visual evoked cortical potential;young adult

PROJECT_TITLE: Nonhuman Primate Model of Inherited Photoreceptor Degeneration

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Cancer

PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward  SHARED RESOURCE MANAGEMENT - PROJECT NARRATIVE  Per PAR-21-321, a Project Narrative is not required for this Component.  OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PI_NAMEs: BACKER, JONATHAN M. (contact)

PROJECT_TERMS: Achievement;Address;Advisory Committees;anti-cancer research;Basic Science;Behavioral;Biology;Cancer Biology;cancer care;Cancer Center;Cancer Center Support Grant;career;Catchment Area;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;college;Communities;community center;cost effective;cost effectiveness;Data;Department chair;Development;Disparity;early-career faculty;Education and Outreach;Ensure;Epidemiology;Etiology;Evaluation;expectation;Faculty;Feedback;Future;Genetic;Goals;Human Resources;Infrastructure;innovation;Institution;Instruction;instrumentation;Investments;Leadership;Malignant Neoplasms;Medicine;meetings;member;Methodology;Molecular;Monitor;new technology;novel;patient population;Patients;Performance;Pharmacology;Population;Population Research;Population Sciences;Principal Investigator;programs;Reporting;Research;Research Support;Resource Sharing;Sampling;Series;Service provision;Services;Shapes;Signal Transduction;social health determinants;Source;Strategic Planning;success;Surveys;Therapeutic;Thinking;Time;tool;Training;Training and Education;Translational Research;Work

PROJECT_TITLE: Shared Resource Management


NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Diabetes;Digestive Diseases;Microbiome;Nutrition;Obesity;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE As currently the most effective and durable treatment for morbid obesity, bariatric surgery has become increasingly common in the US, but its impact on the risk of colorectal cancer remains unclear. Leveraging a longitudinal cohort of bariatric surgery patients and applying multi-omics approaches and fecal microbiota transplant experiments, the proposed study will provide novel knowledge regarding gut microbiota-related mechanisms that impact colorectal cancer risk after bariatric surgery. The gained knowledge may be translated into novel therapies targeting gut microbiota, microbial molecules, and/or immunosurveillance to reduce risk of colorectal cancer among individuals with morbid obesity.

PI_NAMEs: FLYNN, CHARLES R;SHU, XIAO-OU ;YU, DANXIA  (contact)

PROGRAM_OFFICER_NAME: SAUTER, EDWARD RICHARD

PROJECT_TERMS: Address;adenoma;Affect;Age;Antibiotics;Bacteria;Bacteroides;Bacteroides fragilis;bariatric surgery;Bifidobacterium;bile acid metabolism;Bile Acids;Biological;Biology;Blood;Blood Glucose;blood lipid;Blood specimen;Body Weight decreased;C-reactive protein;Cancer Etiology;cancer risk;carcinogenesis;Characteristics;cohort;Collection;Colonic Adenoma;Colonic Neoplasms;Colorectal Cancer;colorectal cancer risk;comorbidity;Complex;Control Groups;Data;Deoxycholic Acid;Development;Diabetes Mellitus;Diet;Disease remission;effective therapy;Endotoxins;Enrollment;Escherichia coli;Etiology;Evaluation;experimental study;Exposure to;Fatty Acids;fecal transplantation;Feces;Fermentation;Fiber;follow-up;Fusobacterium nucleatum;Gastrectomy;Gastric Bypass;Genetic;glycemic control;gut bacteria;gut health;gut inflammation;gut microbes;gut microbiota;host microbiota;Human;Immune response;Immunity;Immunologic Markers;Immunologic Surveillance;Immunologics;improved;in vivo;Individual;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;insight;Insulin Resistance;Knowledge;Life Style;Link;lipopolysaccharide-binding protein;Longitudinal cohort;Longitudinal Studies;Malignant Neoplasms;Medical History;Metabolic;Metabolism;metabolomics;Metadata;Metagenomics;microbial;Molecular;Morbid Obesity;mouse model;Mucins;multiple omics;Mus;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Operative Surgical Procedures;Patients;Pharmaceutical Preparations;Physiology;Pilot Projects;Polyamines;pre-clinical;Pre-Clinical Model;preservation;Procedures;Proteins;Proteomics;Protocols documentation;Race;Research;Resources;response;Risk Factors;Risk Reduction;Role;sex;Shotguns;stool sample;Streptococcus;systemic inflammatory response;Time;Translating;Tumor Burden;tumor growth;Ursodeoxycholic Acid;Visit;Volatile Fatty Acids;Weight;Work

PROJECT_TITLE: Gut microbiota-related mechanisms that impact colorectal cancer risk after bariatric surgery

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: BRONX

PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward  LEADERSHIP, PLANNING AND EVALUATION - PROJECT NARRATIVE  Per PAR-21-321, a Project Narrative is not required for this Component.  OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PROJECT_TERMS: Accountability;Advocacy;Affect;anti-cancer research;Appointment;Area;authority;Awareness;Basic Science;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer health disparity;Cancer health equity;cancer research center director;Caring;Catchment Area;Clinical;clinical care;Clinical Sciences;Clinical Trials;Collaborations;college;Communities;community advisory board;community engagement;Comprehensive Cancer Center;COVID-19 pandemic;design;Discipline;Disease;Education;Elements;Ensure;Environment;equity, diversity, and inclusion;Evaluation;experience;Faculty;Feedback;Fostering;Funding;Goals;high school program;Institution;interdisciplinary collaboration;Investments;Laboratory Research;Lead;Leadership;Malignant Neoplasms;Measures;Medicine;meetings;member;Mission;Modality;Names;NCI Center for Cancer Research;Patient Participation;Patients;Population Sciences;Positioning Attribute;Principal Investigator;Process;Program Evaluation;programs;reconstitution;recruit;Research;Resource Allocation;response;Role;Schedule;Science;social health determinants;Strategic Planning;Structure;success;Training and Education;Translating;Translational Research;Trust;Vision;Work;working group

PROJECT_TITLE: Leadership, Planning and Evaluation