ADMINISTERING_IC: LM

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: JOHNS HOPKINS ACES NARRATIVE Johns Hopkins Bloomberg School of Public Health will develop an Applied Curriculum in Gender and Equity Skills (ACES) in order to increase skills and competencies in gender and health equity among current and future health professionals. ACES will develop, pilot and implement a series of short, intense, online courses to provide training in gender and health equity to health and development professionals with particular focus on applied methods, including using data to promote gender equity and health, gender transformative interventions, gender budgeting, conducting gender situational analyses, gender responsive monitoring and evaluation, and advocacy and communication for gender and health equity.

PI_NAMEs: KALBARCZYK, ANNA  (contact);MORGAN, ROSEMARY

PROGRAM_OFFICER_NAME: BARR, ELIZABETH ANNE

PROJECT_TERMS: Academia;Acceleration;Address;Advertising;Advocacy;Age;Applied Skills;Attention;Budgets;Communication;Community Health;Community of Practice;Competence;Data;Development;Economics;Educational Curriculum;Educational process of instructing;empowerment;Ensure;Equity;Evaluation;experience;Faculty;Foundations;Future;Gender;gender equality;gender equity;gender-based violence;girls;global health;Goals;Government;Health;health equity;Health Personnel;Health Professional;Inequality;International;Intervention;Knowledge;Leadership;Learning;Lived experience;Methods;Monitor;Occupations;online course;Outcome;Participant;Personal Satisfaction;Politics;Positioning Attribute;programs;Public Health;Public Health Schools;Qualifying;Research;Research Methodology;Resources;Scholarship;search engine;Series;skills;social;social inclusion;Specialist;Students;success;Sustainable Development;Time;Training;UNICEF;United Nations;United States;Universities;Woman;Women's Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-K(50)R]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PI_NAMEs: OSMAN, IMAN  (contact)

PROJECT_TERMS: American;Animal Model;animal tissue;Artificial Intelligence;Award;Biological;cancer type;Clinical;Collaborations;college;community center;cost effective;cost effectiveness;Data;digital;disease model;Ensure;Generations;Genetic Engineering;Goals;Health;Human;Human Resources;human tissue;Imaging technology;Immunofluorescence Immunologic;innovation;Institution;International;Link;Melanoma;Melanoma patient;member;Metastatic Melanoma;Mission;Modeling;Molecular;mouse model;Mus;Neoplasm Metastasis;new technology;New York;novel;Pathogenicity;Pathologic;Pathologist;Pathology;Pilot Projects;Process;programs;prospective;Quality Control;repository;Research;Research Infrastructure;Research Project Grants;Resources;Role;Sampling;Services;Societies;success;Technology;Testing;transcriptomics;Translational Research;tumor;Universities;Validation;Work;Xenograft procedure

PROJECT_TITLE: Core 1: Clinicopathological Analysis and Disease Modeling


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Clinical Research;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Skin Cancer

PI_NAMEs: RUGGLES, KELLY VALENTINE (contact)

PROJECT_TERMS: analysis pipeline;Artificial Intelligence;Automobile Driving;Cancer cell line;cancer genomics;cell type;Cells;clinical application;clinically relevant;Code;Communities;Complex;computational pipelines;Computer Analysis;computerized data processing;Computing Methodologies;computing resources;dashboard;Data;data access;Data Analyses;data analysis pipeline;data dashboard;data exploration;data integration;Data Set;data sharing;data standards;data visualization;Development;digital;Dimensions;Disease;Disseminated Malignant Neoplasm;Encyclopedias;Ensure;experience;Fibroblasts;Fostering;Foundations;Future;Genes;Genetic Engineering;genetic signature;Genetic Transcription;genome resource;Goals;Graph;Health;Heterogeneity;Histology;Immunofluorescence Microscopy;Individual;innovation;insight;interactive visualization;interdisciplinary approach;interdisciplinary collaboration;Interdisciplinary Communication;Internet;Intuition;lymph nodes;Malignant Neoplasms;melanocyte;Melanoma;Melanoma Cell;Melanoma patient;melanomagenesis;Metastatic Melanoma;metastatic process;Methods;Microscopic;Microscopy;Modeling;Molecular;mouse model;multiplexed imaging;nano-string;Neoplasm Metastasis;neoplasm resource;neoplastic cell;New York;novel;Pathologic;Pathway Analysis;Patients;predictive modeling;Process;programs;Records;Reporting;Reproducibility;Research;Research Project Grants;Resolution;Resources;Scientist;Signal Pathway;single-cell RNA sequencing;skills;Skin;Specimen;Standardization;success;System;technology platform;Testing;The Cancer Genome Atlas;Time;Tissues;tool;transcriptomics;Translations;tumor;tumor heterogeneity;tumor progression;Tumor Tissue;Universities;Visualization

PROJECT_TITLE: Core 2: Computational and Data Integration


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The germinal center (GC) reaction is a remarkable feature of adaptive immunity that harbors a process of mutation and selection of antibodies, but its utility beyond antibody maturation to generate enhanced binding to antigen has not been explored. The proposed research will engineer flipped germinal center reactions, where antigen is mutated toward user-defined antibody binding. This is relevant to public health because it is expected to provide breakthrough technology for vaccine and biological drug design in addition to having a substantial impact on our understanding of fundamental principles underlying GC immunology.

PI_NAMEs: WESEMANN, DUANE R. (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Acceleration;adaptive immunity;Affinity;Antibodies;Antibody Repertoire;Antibody Response;Antigens;B-Cell Antigen Receptor;Back;Binding;Biological;Biomedical Engineering;booster vaccine;Cell Line;Cloning;Consumption;Coupled;Creativeness;Data;design;Development;Drug Design;Engineering;env Gene Products;Evaluation;Evolution;flexibility;Generations;Genes;Genetic;Genetic Anticipation;Germ Lines;Goals;Hemagglutinin;HIV-1;Human;IGH@ gene cluster;Immune response;Immunity;Immunize;Immunoglobulin Somatic Hypermutation;Immunoglobulins;Immunology;improved;In Vitro;in vivo;Individual;Infection;Influenza;Influenza Hemagglutinin;innovation;Libraries;Ligands;Logic;Mammalian Cell;Methods;Modification;Mus;mutant;Mutate;Mutation;Nature;neutralizing antibody;new technology;operation;Process;protein protein interaction;Proteins;Public Health;Reaction;Receptor Signaling;Research;screening;Structure of germinal center of lymph node;success;System;T-Lymphocyte Epitopes;technological innovation;Technology;Testing;Time;time use;tool;universal vaccine;Vaccination;Vaccines;Validation;Variant;Viral;Viral Envelope Proteins;Virus;Work;Yeasts

PROJECT_TITLE: Flipped Germinal Centers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


ADMINISTERING_IC: GM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Defects in mitochondrial biogenesis and homeostasis are implicated in aging and many diseases such as neurodegenerative diseases and cardiovascular diseases. Cellular mechanisms to import most of mitochondrial precursor proteins from the cytosol are poorly understood. In this project, we will elucidate the structural basis by which mitochondrial protein translocases import proteins into mitochondria to advance our understanding of the mitochondrial biogenesis pathways and to provide new insights for therapeutic interventions in mitochondrial-associated diseases.

PI_NAMEs: PARK, EUNYONG  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;Aging;Apoptosis;Architecture;Area;ATP phosphohydrolase;Binding;Biochemical;Biogenesis;Biology;biophysical analysis;biophysical techniques;Cardiovascular Diseases;Cells;Client;Complex;Couples;Cryoelectron Microscopy;Cytosol;Data;Defect;Disease;driving force;Genome;Goals;Homeostasis;Human;human disease;Innate Immune Response;Inner mitochondrial membrane;insight;Integral Membrane Protein;Maintenance;Manuscripts;Mediating;Membrane;Metabolic syndrome;Metabolism;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Molecular;Molecular Conformation;molecular dynamics;Molecular Machines;Multiprotein Complexes;Nerve Degeneration;Neurodegenerative Disorders;novel strategies;Nuclear;Organelles;Outcome Study;Outer Mitochondrial Membrane;Oxidative Phosphorylation;Pathogenesis;Pathway interactions;Permeability;Phosphotransferases;Physiology;PINK1 gene;Play;polypeptide;Process;Protein Biosynthesis;Protein Import;Protein Inhibition;Protein Precursors;Protein translocation;Proteins;Publishing;Quality Control;Research;Resolution;Respiration;Rest;Ribosomes;Role;Saccharomyces cerevisiae;Signal Transduction;small molecule;Sorting;Structure;Testing;Therapeutic Intervention;therapeutically effective;Thinness;translocase;Visualization;Water

PROJECT_TITLE: Molecular Mechanisms of Mitochondrial Biogenesis

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: CLEVELAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Population health protocols lack efficient and effective methods to screen cognitive health. The tools proposed in this research may provide a low-cost, scalable method to improve detection of cognitive decline.

PI_NAMEs: FLODEN, DARLENE  (contact);FOX, ROBERT J.

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Adopted;Adoption;Adult;Age;aged;Alzheimer's Disease;Alzheimer's disease related dementia;Appointment;arm;Attitude;Behavior;Characteristics;Clinic;Clinical;Clinical Data;cluster randomized design;Cognitive;cognitive change;cognitive performance;cognitive testing;cohort;comparison control;Computerized Medical Record;Computers;cost;Data;Detection;Development;Diagnosis;Disease;Early Diagnosis;Effectiveness;effectiveness/implementation study;Electronic Health Record;Epilepsy;Ethnic Origin;Excision;flexibility;follow-up;Frequencies;Future;Genetic;Geography;Geriatrics;Goals;Health;health disparity;Health Status Indicators;Health system;high risk;Human Resources;Image;Impaired cognition;implementation efforts;implementation evaluation;implementation outcomes;implementation strategy;implementation tool;improved;innovation;Institution;Internal Medicine;Intervention;Interview;Location;Machine Learning;Measures;Medical Records;Medicine;Mental Depression;Methods;mild cognitive impairment;Modeling;Moods;Neurology;Neuropsychological Tests;Neuropsychology;Operative Surgical Procedures;Paper;Patient Care;patient health information;Patient risk;patient screening;Patients;Performance;Persons;Pharmaceutical Preparations;Phase;Population;population health;Pragmatic clinical trial;pragmatic trial;predictive modeling;Primary Care;primary care patient;primary care practice;primary care provider;primary care setting;Probability;Process;prospective;Protocols documentation;Provider;provider behavior;Questionnaires;Race;Randomized;recruit;regional difference;Reporting;Research;Risk;Sampling;screening;Screening procedure;Screening Result;Self Administration;Sleep;Sleep Disorders;Sleep disturbances;sociodemographics;socioeconomics;standard of care;Stress;Suggestion;Symptoms;System;Techniques;Testing;Time;tool;uptake;Validation;Variant

PROJECT_TITLE: A Cognitive Risk Calculator and Screening tool for Primary Care Settings


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: PHILADELPHIA

ORG_NAME: RESPANA THERAPEUTICS, INC.

ORG_STATE: PA

PHR: Narrative: Respana Therapeutics is developing a novel and proprietary monoclonal antibody, RT-002, targeting surfactant protein A receptor SP-R210 to address the urgent public health need for interventions that address the considerable morbidity and mortality resulting from pulmonary complications of influenza. Respana intends to advance its antibody by: 1) demonstrating efficacy of RT-002 in humanized mice; 2) determining the impact of humanized P2H10 mAb in cytokine responses in human blood and respiratory secretions; and 3) executing critical steps for transition of RT-002 to clinical testing. This work will facilitate progression toward IND-filing and initial human trials of a new therapeutic that addresses the shortcomings of existing therapies, including waning efficacy due to pathogen evolution.

PI_NAMEs: LARK, MICHAEL WILLIAM (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: Acceleration;Acute;Address;Adult;airway obstruction;Alveolar Macrophages;Animal Model;Anti-viral Agents;Antibodies;Applications Grants;Asthma;Biochemical;Biological Assay;biophysical properties;Blood;Body Weight;candidate selection;Certification;Cessation of life;Childhood;Chinese Hamster Ovary Cell;Chronic;Clinical;clinical candidate;Clinical Trials;clinically relevant;commercialization;cost estimate;Critical Illness;cytokine;design;Development;differential expression;disability;dosage;Drug Kinetics;Drug resistance;Economics;Evolution;Fibrosis;Foundations;Goals;high risk;Hospitalization;Human;humanized mouse;Hypoxia;immune activation;Immunophenotyping;Impaired cognition;improved outcome;in vivo;Individual;Infection;Infection prevention;Inflammation;Inflammatory;Influenza;influenza infection;Injectable;innovation;interstitial;Intervention;Lead;lead candidate;Life;Lung;lung health;Measures;Mediating;Medical;Medical Care Costs;Monoclonal Antibodies;Morbidity - disease rate;mortality;murine monoclonal antibody;Mus;neonatal Fc receptor;novel;novel therapeutics;pandemic disease;pandemic influenza;pathogen;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmacodynamics;pharmacologic;Pharmacologic Actions;Phase;phase 1 designs;pre-Investigational New Drug meeting;preclinical efficacy;Preclinical Testing;Prevention;product development;Production;Protein Isoforms;prototype;Public Health;Recovery;Reporting;Research;research clinical testing;Resolution;respiratory;Respiratory physiology;Respiratory Tract Infections;response;restoration;Risk;Safety;Schedule;seasonal influenza;Small Business Technology Transfer Research;standard of care;surfactant protein A receptor;Survivors;Testing;Therapeutic;therapeutic candidate;Therapeutic Monoclonal Antibodies;timeline;tool;Toxic effect;treatment duration;trend;United States;vaccine hesitancy;Vaccines;Validation;Virus Diseases;Work;Writing

PROJECT_TITLE: Treatment of Inflammatory Complications of Respiratory Infection


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Services;Hematology;Infectious Diseases;Pediatric;Sepsis

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE - University of Minnesota This proposal is relevant to public health because the University of Minnesota Masonic Children's Hospital and our ancillary site, Children's Minnesota, will enroll children from a variety of social, economic, and racial backgrounds from throughout the Upper Midwest to CPCCRN studies. The proposed project investigates the impact of individual immune function profiles and treatment on organ dysfunction from sepsis and whether treated children recover more fully following their illness and therefore requires a diverse patient population to adequately address this personalized question. UMMCH's role as a clinical site is relevant to the NICHD CPCCRN's mission to care for all critically ill and injured children, and to reduce the impact of illness and disability on every child.

PI_NAMEs: STEINER, MARIE E (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Address;Admission activity;Advisory Committees;ancillary care;Anti-Inflammatory Agents;Applied Skills;Asian population;base;Beds;Bioinformatics;Cardiac;Caring;Child;Child Health;Child health care;Childhood;Childhood Injury;Clinical;clinical center;Clinical Research;clinical research site;Clinical Trials;Collaborations;Collection;Communicable Diseases;Communities;Complement;Contracts;Critical Care;Critical Illness;Critically ill children;Data;Data Coordinating Center;Dedications;Development;Devices;dietary;disability;Discipline of Nursing;Doctor of Philosophy;Ebola;Ebola virus;Economics;Enrollment;Ethics;Ethnic Origin;expectation;experience;Faculty;Family;Fellowship;forging;Functional disorder;Future;Good Clinical Practice;Grant;Granulocyte-Macrophage Colony-Stimulating Factor;Health;health care service organization;health related quality of life;Hematology;Illness impact;immune function;Immunophenotyping;immunoregulation;immunosuppressed;Individual;industry partner;innovation;Institution;interest;International;Intubation;Knowledge;knowledge base;Leadership;Manuscripts;Measures;Medical;Medicine;meetings;member;Mentors;Mentorship;Midwestern United States;Minnesota;Mission;Multicenter Trials;Multiple Organ Failure;National Institute of Child Health and Human Development;Native Americans;Nosocomial Infections;Observational Study;Oncology;Operative Surgical Procedures;Organ;Organ Donations;Organ Transplantation;organizational structure;Outcome;participant enrollment;pathogen;patient population;Patient Recruitments;Patients;Pediatric Acute Lung Injury;pediatric department;Pediatric Hospitals;Pediatric Intensive Care Units;pediatric sepsis;Pennsylvania;Performance;Pharmacologic Substance;Pharmacy facility;Population;Positioning Attribute;Prevention;Principal Investigator;Procedures;product development;Protocols documentation;Public Health;Race;Recording of previous events;Recovery;Registries;Research;Research Personnel;Research Training;Respiratory Therapy;Role;Running;sample collection;Scientist;Sepsis;Services;severe injury;Site;skills;social;Socioeconomic Status;socioeconomics;southeast Asian;success;surgical service;System;Talents;Time;Training;Translational Research;translational study;Trauma;treatment center;United States;Universities;University resources;venous thromboembolism;Work

PROJECT_TITLE: Collaborative Pediatric Critical Care Research Network - Clinical Site


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Lung;Pediatric;Sepsis

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE - University of California Consortium The Eunice Kennedy Shriver National Institutes of Child Health and Development (NICHD) Collaborative  Pediatric Critical Care Research Network (CPCCRN) was established in 2004 to address the need for carefully  planned and well designed, prospective, multicenter clinical trials for infants and children with Critical Illness.  This proposal seeks to establish a University of California Consortium (UCC) hub site consisting of UCSF  Benioff Children Hospital’s at San Francisco and Oakland along with UCLA Mattel Children’s Hospital. UC  Davis will join the UCC as ancillary site, allowing us to participate fully in the “Personalized Immunomodulation  in Sepsis-induced MODS” trial described in this application.

PI_NAMEs: MCQUILLEN, PATRICK SEAN (contact)

PROJECT_TERMS: Address;Admission activity;Ancillary Study;Award;Beds;Biological Markers;Brain Injuries;California;Child;Child Development;Child Health;Childhood;Clinical;Clinical Research;clinical research site;Clinical Trials;Coagulation Process;Collaborations;Contracts;Critical Care;Critical Illness;Data;Data Coordinating Center;Databases;design;early-career faculty;Ethnic Origin;expectation;experience;Faculty;Family;Funding;Gene Expression;Geography;Goals;Good Clinical Practice;Health;Hypoxemic Respiratory Failure;Immune response;Immunocompromised Host;immunoregulation;Individual;Infant;Inflammation;innovation;Lead;Los Angeles;Lung;lung microbiome;Machine Learning;Manuscripts;meetings;Mentors;metabolomics;metatranscriptomics;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;National Heart, Lung, and Blood Institute;Natural Language Processing;Network Infrastructure;Nurses;Obesity;Outcome;outcome prediction;participant enrollment;Pediatric Acute Lung Injury;Pediatric Hospitals;pediatric sepsis;Performance;Physiology;Population;Procedures;Productivity;programs;prospective;Protocols documentation;Publishing;racial diversity;Recording of previous events;Research;Research Personnel;Research Training;Respiratory Failure;Risk;San Francisco;Scientist;Sepsis;Site;success;Talents;United States National Institutes of Health;Universities;ward;Work


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Heart Disease;Hematology;Infectious Diseases;Kidney Disease;Pediatric;Sepsis

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE – Baylor College of Medicine/Texas Children’s Hospital Baylor College of Medicine Texas Children’s Hospital and Children’s Hospital of San Antonio look forward to  being new clinical sites in the newly organized and expanded Collaborative Pediatric Critical Care Research  Network (CPCCRN). Our participation will contribute significantly to the success of CPCCRN, development of  talented clinician scientists, and completion of our highly innovative clinical trial aimed at reducing the morbidity  and mortality of multiple organ dysfunction in critically ill infants and children.

PI_NAMEs: AKCAN ARIKAN, AYSE  (contact);NGUYEN, TRUNG CHANH

PROJECT_TERMS: Acute Lung Injury;Acute Renal Failure with Renal Papillary Necrosis;Admission activity;Area;Arrhythmia;Attenuated;Beds;Bile Acids;Blood;Blood Platelets;Cardiac;Cardiac Surgery procedures;Cardiomyopathies;Cardiovascular system;career development;Catchment Area;Center for Translational Science Activities;Child;Childhood;Cirrhosis;Clinical;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;cohort;Collaborations;college;Communities;Contracts;COVID-19;Critical Care;Critical Illness;Data;Data Coordinating Center;Development;Digestive System Disorders;Disease;Drug Kinetics;Endothelium;Enrollment;Ethics;ethnic diversity;Ethnic Origin;expectation;Extramural Activities;Faculty;Family suidae;Fostering;Functional disorder;Funding;Goals;Good Clinical Practice;Grant;Heart;Hematology;Hispanic;Hospitals;Immune;Immune System Diseases;immunoregulation;improved outcome;Individual;Infant;Inflammation;Inflammatory;innovation;Intensive Care;International;Intervention Trial;Investigational Drugs;Kidney;Leadership;Leukocytes;Life;Liver;Liver Failure;machine learning algorithm;mechanical circulatory support;Medical center;medical specialties;Medicine;meetings;Mentored Clinical Scientist Development Program;Mentors;Mission;Modeling;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Multicenter Trials;Multiple Organ Failure;Myocardial;National Institute of Child Health and Human Development;Neonatal;Nephrology;news;novel;novel therapeutics;Oncology;Operative Surgical Procedures;Organ;Outcome;participant enrollment;Pathologic;Patients;Pediatric Acute Lung Injury;pediatric department;Pediatric Hospitals;Performance;Persons;Phenotype;Population;Population Heterogeneity;porcine model;pre-clinical;Principal Investigator;Procedures;programs;prospective;Proteins;Protocols documentation;Publications;Randomized;Recording of previous events;Reporting;Research;Research Institute;Research Personnel;Research Project Grants;Research Training;Resources;Respiratory Diaphragm;Scientist;Sepsis;septic patients;Services;Site;success;System;Talents;Techniques;Texas;Therapeutic Agents;Thrombosis;Training;Training Programs;Translational Research;United States;United States Food and Drug Administration;United States National Institutes of Health;Work


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Hematology;Infectious Diseases;Precision Medicine;Sepsis

ORG_CITY: DETROIT

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Narrative Sepsis—the term for when the body’s response to infection becomes harmful rather than helpful—is a common condition that kills millions of people worldwide every year, yet over the last 20 years, treatments have not substantially improved and the mortality rate has not gone down. This is largely due to the fact that the processes that lead to organ failure in sepsis are poorly understood, leading all patients to be treated exactly the same despite obvious differences between them. This project will identify factors that contribute to organ dysfunction in sepsis, a necessary first step towards identifying the disease as early as possible and developing specialized treatments for the many complications that sepsis can cause.

PI_NAMEs: EHRMAN, ROBERT RUSSELL (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Accident and Emergency department;adverse outcome;Biological Markers;biomarker development;biomarker panel;care costs;Data;data streams;Death Rate;Disease;Echocardiography;Functional disorder;Generations;Guidelines;heart function;Heterogeneity;Hospitalization;Hypertension;improved;Individual;Infection;Intervention;Investigation;IV Fluid;Kidney;Knowledge;Laboratories;liver function;longitudinal database;Lung;Machine Learning;Microscopic;Morbidity - disease rate;mortality;Myocardial dysfunction;novel;Organ;Organ failure;Outcome;patient oriented;Patient-Focused Outcomes;Patients;personalized care;Persons;Phenotype;Process;profiles in patients;Prognosis;pulmonary function;Recommendation;Renal function;response;Risk;Sepsis;septic;septic patients;serial imaging;Specific qualifier value;Stress;System;targeted treatment;Time;Ultrasonography;Vascular Endothelium;Venous

PROJECT_TITLE: Profiles and impact of venous congestion on organ function and patient outcomes in sepsis

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Estrogen;Neurosciences;Sleep Research;Women's Health Research

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Women experience considerably more sleep problems than men, putting women at an elevated risk for cognitive and mood disorders as well as immune, metabolic and cardiovascular dysfunction. Gonadal steroids and gender are risk factors for sleep disruptions and insomnia. Yet, the exact mechanisms of how ovarian steroids influence the sleep-wake neurocircuitry remains a significant gap in our knowledge. The proposed research will elucidate novel mechanisms of steroid hormone action in the nervous system, providing new perspectives on the basis of sleep disturbance in the female brain.

PI_NAMEs: MONG, JESSICA AURORA (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Address;Adenosine;Adenosine A1 Receptor;ADORA2A gene;Agonist;Animals;antagonist;Astrocytes;Attenuated;biological sex;Brain;Calcium;Calcium Signaling;Cardiovascular system;Cognition Disorders;Curiosities;Cyclic AMP;Data;Disease;Equilibrium;Estradiol;estrogenic;Estrogens;Etiology;experience;extracellular;Female;Fiber;Functional disorder;Gases;Gender;Genetic;Goals;Gonadal Steroid Hormones;Grant;Health;heuristics;Hypothalamic structure;Immune;improved;Individual;Infusion procedures;innovation;insight;Intervention;Knowledge;Laboratories;life span;Link;Maintenance;Mediating;Meditation;men;Metabolic;Modeling;Modernization;Mood Disorders;Nervous System;neural circuit;neuromechanism;Neuronal Plasticity;Neurons;Neurosciences;novel;Ovarian;Pathology;Periodicity;Pharmacology;Photometry;Preoptic Areas;preoptic nucleus;prevent;Production;Puberty;Rat Transgene;Rattus;receptor;Receptor Activation;Receptor Signaling;Research;Risk;Risk Factors;Role;Scanning;sex;sex as a biological variable;sex disparity;Signal Transduction;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep quality;sleep regulation;Sleeplessness;steroid hormone;Steroids;Techniques;Testing;Therapeutic;vigilance;Woman;Women's prevalence;Work

PROJECT_TITLE: Mechanisms Governing the Estrogenic Modulation of Sleep

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE Approximately 300,000 individuals are living with spinal cord injury (SCI) in the USA without an effective treatment. Recently, spinal cord stimulation during rehabilitation has been found to enable better standing, stepping, and voluntary control in patients with SCI. This study will improve our understanding of these mechanisms by 1) using new genetic tools to identify which afferents are necessary and sufficient for improvement, and 2) using genetic tracing techniques to uncover how spinal circuits are changing to enhance function.

PI_NAMEs: SPENCE, ANDREW  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Affect;Afferent Neurons;Animal Model;Animals;Axon;Behavioral;Complex;Coupled;Cutaneous;Data;Data Set;deep learning;density;designer receptors exclusively activated by designer drugs;Diameter;Dissection;effective therapy;Electric Stimulation;Euthanasia;Exclusion;feeding;functional plasticity;Genetic;genetic manipulation;Goals;Grant;H-Reflex;Histologic;Human;human model;Impairment;improved;Individual;Injury;injury recovery;Interneurons;kinematics;Lesion;Locomotor Recovery;Maps;Mediating;Methods;Modeling;Motor;Motor Neurons;Motor output;Movement;neural;neural circuit;neural network;neural stimulation;Neurologic;neuronal excitability;Neuronal Plasticity;Neurons;neurophysiology;neuroregulation;Neurostimulation procedures of spinal cord tissue;novel;novel strategies;Outcome;Parvalbumins;Patients;Play;Population;Rattus;Recovery;Recovery Support;recruit;Rehabilitation therapy;Role;selective expression;Sensory;sensory input;Spinal;Spinal Cord;Spinal Cord Contusions;Spinal cord injury;Synapses;Tactile;Techniques;Testing;Toes;tool;Tracer;Training;treadmill training;vector;Walking;Work

PROJECT_TITLE: Chemogenetic afferent modulation to understand spinal cord circuit function and plasticity post injury

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Skin Cancer

ORG_CITY: TUCSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Advances in molecular understanding of the process of cancer development and progression, including genomic, metabolic and immune hallmarks, have led to the study of an increasing number of agents to intercept the early phases of cancer development for cancer prevention. The overall objective of University of Arizona Cancer Prevention Clinical Trials Network is to perform early phase clinical trials to evaluate the biologic effects of putative preventive agents and to determine clinically relevant correlates in order to identify agents with good safety profiles and preliminary efficacy. Scientific and clinical evidence generated from these early phase cancer prevention clinical trials will contribute significantly to the decision for further clinical development of putative agents for cancer prevention.

PI_NAMEs: BAUMAN, JULIE E;THOMPSON, PATRICIA ANN (contact)

PROGRAM_OFFICER_NAME: JOHNSEY, DONALD

PROJECT_TERMS: Affect;Arizona;Biochemical;Biological;Biological Markers;biomarker identification;cancer clinical trial;cancer invasiveness;cancer prevention;carcinogenesis;Chemoprevention;Chronic Disease;Clinical;clinical development;Clinical Research;Clinical Trials;Clinical Trials Design;Clinical Trials Network;clinically relevant;Collaborations;Contracts;Data;design;Development;Dose;Drug Delivery Systems;drug repurposing;early phase clinical trial;efficacy trial;epidemiology study;Evaluation;experience;Foundations;Funding;Genomics;Human Resources;Immune;Immunologic Surveillance;Immunomodulators;Immunoprevention;Incidence;insight;Intercept;interest;Lead;Leadership;Lesion;Longterm Follow-up;Lung;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;medical specialties;Melanoma;Metabolic;Molecular;Molecular Target;new technology;Normal tissue morphology;novel;Nutraceutical;Organ;Organizational Affiliation;Participant;Pathologist;Pathway interactions;pharmacokinetics and pharmacodynamics;Phase;phase III trial;Physicians;potential biomarker;preclinical study;premalignant;Preparation;prevention clinical trial;Preventive;primary endpoint;Process;protocol development;Regulation;Research;response;Safety;Schedule;Site;skin cancer prevention;Skin Carcinoma;Surrogate Endpoint;surveillance network;Tissues;Translational Research;translational scientist;Universities;Urologic Cancer;Work

PROJECT_TITLE: University of Arizona Cancer Prevention Clinical Trials Network (UA CP-CTNet)


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cancer;Drug Abuse (NIDA only);Genetics;Neurosciences;Substance Misuse

ORG_CITY: DAVIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: KOMP2-Phase3 Production and Phenotyping by the DTCC Consortium  PUBLIC HEALTH RELEVANCE (NARRATIVE STATEMENT) The normal sequence of every gene in the human genome is known. But how do abnormal changes in a gene’s sequence cause or contribute to disease? These changes, called mutations, can either be inherited (like the mutation that causes cystic fibrosis) or acquired during a person's life (like the mutations that cause many types of cancer). If researchers can learn how mutations cause diseases, they can better understand how to prevent them or develop drugs to prevent or treat them. Fortunately, the genes and biology of mice and humans are very similar and mouse genes can be easily mutated. But scientists need strains of mice with a mutation in every gene to explore how any one mutated gene causes disease. This project will create mouse models with single gene mutations for 600 human genes, especially genes with little to no known functional information. We will also analyze them with the same kind of tests used on people like vision tests, blood samples, and medical imaging to identify abnormalities (called ‘phenotypes’) that might be caused by any of the mutated genes. Our project will ask the community which genes to work on, and all the mutated mouse models and phenotype data will be available to any scientist around the world. We will also do technology development to improve how we produce and phenotype mice and share that information with the scientific community. All with a goal to improve human health.

PI_NAMEs: LLOYD, KC KENT (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Acceleration;Adolescent;Adult;Age;Alleles;Biological;Biology;Biomedical Research;Blood specimen;Body System;Budgets;California;Canada;cancer type;Cells;cohort;Communities;cost effectiveness;CRISPR/Cas technology;Cystic Fibrosis;Data;data archive;Data Coordinating Center;Databases;design;Disease;Electronic Mail;Electroporation;Embryo;experience;Freezing;Funding;Gene Mutation;Genes;genome editing;Genotype;Germ;Germ Lines;Goals;Grant;Guide RNA;Health;Heterozygote;Home;Human;Human Genome;Image;improved;Inherited;interest;International;Knockout Mice;Learning;Life;Magnetic Resonance Imaging;mammalian genome;Medical Imaging;meetings;member;Metadata;Monitor;mouse model;Mouse Strains;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;nuclease;Orthologous Gene;Output;Persons;Pharmaceutical Preparations;Phase;Phenotype;phenotypic data;prevent;Procedures;Process;Production;programs;Protocols documentation;public health relevance;quality assurance;Quality Control;Recommendation;Research;Research Personnel;Resources;Scientist;sex;Site Visit;Standardization;Statistical Data Interpretation;symposium;technology development;Testing;Time;tissue fixing;United States National Institutes of Health;Universities;videoconference;Vision Tests;web portal;Work;zygote

PROJECT_TITLE: KOMP2-Phase3 Production and Phenotyping by the DTCC Consortium.


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: FORT COLLINS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE Chromosomes are duplicated by complex molecular machines called replisomes, which frequently encounter obstacles during DNA replication such as DNA damage, RNA:DNA hybrids, and nucleosomes, which are the basic units of chromatin that preserve epigenetic features across generations. Failure to preserve genomic information as it is copied is known to lead to a broad array of human pathologies; therefore, the candidate proposes to elucidate the molecular mechanisms of processes, collectively called damage tolerance, that allow replication through various obstacles on DNA while strictly enforcing genomic and epigenetic fidelity. The proposed research is poised to provide critical insight into cellular processes that underlie reliable and accurate chromosomal heritage and is designed to add fundamental knowledge that enhances our ability to treat and/or prevent diseases regulated by these processes.

PI_NAMEs: SCHAUER, GRANT  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Biochemical;Biochemistry;Biophysics;Bypass;Cell division;Cell Extracts;Cell Physiology;Cells;Cellularity;Chromatin;Chromosomal Instability;Chromosomes;Closure by clamp;Communities;Complex;Coupled;Deposition;design;Disease;disorder prevention;DNA;DNA biosynthesis;DNA Damage;DNA replication fork;ds-DNA;dynamic system;Ensure;Epigenetic Process;Failure;Generations;Genetic;Genetic Transcription;Genome;genome integrity;Genomics;Goals;Histones;Holoenzymes;Human Pathology;Hybrids;improved;insight;intermolecular interaction;Knowledge;Label;Lesion;Malignant Neoplasms;Mediation;Mediator;Medical Research;Molecular;Molecular Chaperones;Molecular Machines;Motion;Nucleosomes;Pathway interactions;Phosphotransferases;Polymerase;polypeptide;preservation;prevent;Process;protein purification;Proteins;reconstitution;Regulation;Replication Initiation;Replication Origin;Research;response;RNA;S phase;single molecule;single-molecule FRET;Slide;spatiotemporal;structural biology;System;Technology;tool;Transcription Elongation;Transcriptional Regulation;Ubiquitination

PROJECT_TITLE: Bypass Mechanisms in Eukaryotic Replication


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Pediatric;Sepsis

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE – University of Michigan The incidences of some of the most challenging diseases that contribute to pediatric critical illness, notably  acute respiratory distress syndrome and sepsis, are such that relying on any one center to execute a single site study that will advance both our understanding and management of these diseases is ineffective. In order  to improve the care of this vulnerable population of critically ill children, the Eunice Kennedy Shriver National  Institute of Child Health and Human Development (NICHD) has addressed this by funding an infrastructure for  a multicenter research network, the Collaborative Pediatric Critical Care Research Network (CPCCRN) and the  accompanying clinical trial examining the efficacy of GM-CSF in children with sepsis entitiled, Personalized  Immunomodulation in Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS). This application will  position our Pediatric Critical Care Medicine Research Program at the University of Michigan and our ancillary  site at the Pediatric Critical Care Division at the Medical College of Wisconsin to actively participate and  contribute in this important national network.

PI_NAMEs: QUASNEY, MICHAEL W (contact)

PROJECT_TERMS: Address;Admission activity;Beds;Cardiac;Caring;Child;Child Development;Child Health;Childhood;Childhood Injury;clinical research site;Clinical Trials;Clinical Trials Network;Collaborations;Contracts;Critical Care;Critical Illness;Critically ill children;Data;Data Coordinating Center;Death Rate;Development;Disease;Disease Management;efficacy evaluation;expectation;Faculty;Funding;Goals;Good Clinical Practice;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;Healthcare;immunoregulation;implementation science;improved;Incidence;Individual;Infrastructure;insight;Institution;interdisciplinary approach;interest;International;Leadership;Lung;Medical;medical schools;Medicine;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Michigan;mindfulness;Multi-Institutional Clinical Trial;Multiple Organ Failure;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;neurodevelopment;novel;Outcome;Paper;participant enrollment;Pediatric Acute Lung Injury;Pediatric Acute Respiratory Distress Syndrome;Pediatric Hospitals;Performance;Population;Positioning Attribute;Principal Investigator;Procedures;Process;Program Development;programs;Protocols documentation;Publishing;Recording of previous events;Research;Research Personnel;Research Training;Resources;Sales;Scientist;Sepsis;sepsis induced ARDS;severe injury;Site;success;Talents;tertiary care;Training;Trauma;United States National Institutes of Health;Universities;Vision;Vulnerable Populations;Wisconsin;Work


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Human Genome;Mental Health;Microbiome;Nutrition;Obesity;Prevention

ORG_CITY: GAINESVILLE

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: This project investigates the mechanisms underlying microbial modulation of behavior. We will integrate single-cell transcriptomics, metabolomics, Drosophila genetics, and quantitative behavioral assays to reveal to what extent and how host genetics-microbiome interactions shape feeding behavior and food preferences. The results will advance foundational knowledge of behavioral genetics and may yield molecular targets for developing treatments to combat diseases caused by behavioral disorders.

PI_NAMEs: WONG, CHUN NIN ADAM  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;Affect;Behavior;Behavior Control;Behavior Disorders;Behavioral;Behavioral Assay;Behavioral Genetics;behavioral outcome;behavioral phenotyping;Biology;Brain;Cells;Choice Behavior;combat;Communication;Complex;Data;Diet;Disease;Drosophila genus;Drosophila melanogaster;Eating Disorders;Endocrine;feeding;Feeding behaviors;Five-Year Plans;fly;Food;food environment;Food Preferences;Gene Expression Regulation;gene interaction;gene regulatory network;Genes;Genetic;Genetic Predisposition to Disease;Genetic Transcription;Genomics;Gnotobiotic;Goals;Habits;Health;host-associated microbial communities;host-microbe interactions;Human;Individual;Individual Differences;Individuality;Knowledge;Mammals;Maps;metabolomics;Microbe;microbial;microbiome;microbiome alteration;Molecular;Molecular Target;Neuropeptides;Obesity;Organ;Outcome;Population;preference;Process;programs;Research;Shapes;Signal Transduction;Symbiosis;System;tool;trait;transcriptome;transcriptomics

PROJECT_TITLE: Molecular mechanisms underlying microbial modulation of host behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE With 10 million residents, Los Angeles County is the most populous in the US; three-quarters of residents identify as ethnic minorities and more than one-third were born outside the US; and nearly 1.5 million people are below the poverty line. Rates of premature death and disability related to heart disease, diabetes, stroke and violence exceed national averages; the disease burden is magnified by language barriers, cultural beliefs, poverty and disparities in access to care. The goal of the CTSI is to bring biomedical innovations to bear on the greatest health needs of Los Angeles—one of the nation’s most ethnically, socially and economically diverse counties.

PI_NAMEs: BROWN, ARLEEN F. (contact);NAEIM, ARASH ;WONG, MITCHELL DAVID

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: Acceleration;access disparities;Address;Adopted;Artificial Intelligence;Award;Belief;biomedical informatics;black men;Blindness;burden of illness;California;Caring;Cessation of life;Child;Clinical;clinical data warehouse;Clinical Sciences;Collaborations;Communities;community partners;County;COVID-19;Critical Care;Data;data resource;Data Science;Data Sources;data warehouse;design;Diabetes Mellitus;Diabetic Retinopathy;disability;Entrepreneurship;equity, diversity, and inclusion;ethnic diversity;ethnic minority;Ethnic Origin;experience;Extramural Activities;Faculty;Goals;Good Clinical Practice;Health;health disparity;Health Occupations;Health Services Accessibility;Health system;Heart Diseases;Hypertension;improved;Incidence;Informatics;Infrastructure;innovation;Institution;Investments;Language;Los Angeles;Malignant Breast Neoplasm;Malignant neoplasm of lung;Medical center;Medicine;Methods;mHealth;Mission;Modeling;Molecular;multidisciplinary;novel strategies;older adult;Operative Surgical Procedures;Outcome;Patients;Persons;Pharmacists;population health;Poverty;Precision Health;premature;Process;programs;Public Health;Publications;Records;Research;Research Infrastructure;Research Methodology;Research Personnel;safety net;Science;screening;shared decision making;Site;social;Special Population;Stroke;System;Time;TNFSF15 gene;Training;Training and Education;Training Programs;Translating;translational impact;translational pipeline;Translational Research;Translations;Universities;Violence

PROJECT_TITLE: UCLA Clinical and Translational Science Institute


NIH_SPENDING_CATS: Aging;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Disability Research;Dissemination and Implementation Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Post-Traumatic Stress Disorder (PTSD);Prevention;Rare Diseases;Social Determinants of Health;Telehealth

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Cancer among Adolescents and Young Adults (AYAs) is associated with poor psychosocial outcomes and quality of life, and patients experience disproportionately high levels of anxiety, depression, and posttraumatic stress in relation to their younger pediatric and older adult counterparts. Findings from the proposed project will help address the unmet psychosocial needs of AYA cancer patients using a novel mobile health psychosocial care delivery model with the advantages of appeal, reach, and cost-effectiveness. Ultimately, this work may help improve patient health-related quality of life and emotional well-being, and reduce the burden of cancer, by expanding access to evidence-based care.

PI_NAMEs: LAU, NANCY  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adopted;Adoption;Age;age related;Anxiety;Behavior Therapy;Behavioral;Cancer Burden;Cancer Patient;career;career development;Caring;Cellular Phone;Childhood;Chronic Disease;Clinic;Clinical;Clinical Trials;Cognitive;Cognitive Therapy;cohort;Collaborations;coping;cost;cost effectiveness;Dedications;Dependence;design;Development;Development Plans;digital;digital technology;disability;Distress;Dose;Education;Educational process of instructing;effectiveness/implementation trial;Employment;Enrollment;Environment;evidence base;experience;follow-up;Funding;Future;Gender;Goals;Health behavior;Health Personnel;health related quality of life;Health Services Accessibility;high risk;implementation measures;implementation outcomes;implementation science;implementation strategy;Improve Access;improved;improved outcome;innovation;interest;Intervention;Interview;Knowledge;Linear Regressions;Long Term Survivorship;Malignant Neoplasms;Measures;Medical;meetings;Mental Depression;Mental Health;Mentors;Mentorship;Methodology;Methods;mHealth;mhealth interventions;mindfulness;mindfulness intervention;Modeling;multidisciplinary;novel;older adult;Oncology;Outcome;patient engagement;Patients;Pattern;Persons;pilot trial;Population;portability;post-traumatic stress;prevent;programs;promote resilience;psychosocial;Psychosocial Assessment and Care;psychosocial outcome;Qualitative Methods;Qualitative Research;Quality of life;Race;Randomized;randomized trial;Recording of previous events;Research;research and development;Research Methodology;Research Personnel;resilience;response;retention rate;Risk;scale up;Scientist;Secure;self help;Service delivery model;Site;skill acquisition;skills;Social isolation;Statistical Methods;Stress;stress management;Structure;Technology;Testing;theories;Time;Training;treatment as usual;treatment effect;Unemployment;usual care arm;Waiting Lists;Well in self;Work;young adult;Youth

PROJECT_TITLE: Pilot trial testing mobile health psychosocial intervention for Adolescentsand Young Adults with cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Temporary labor migrants who inject drugs are at exceptionally high risk for acquiring HIV and transmitting it between country borders. Intersectional stigma associated with migrant status, illicit drug use, and HIV promotes risky behavior and inhibits preventative action. Interventions to reduce stigma would potentially contribute to reductions in HIV transmission and acquisition in this population.

PI_NAMEs: MACKESY-AMITI, MARY ELLEN (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adopted;Adoption;Adverse effects;Affect;AIDS prevention;Asian;Attitude;Behavior;Behavioral;Belief;Central Asia;Communities;Country;design;Diffusion;Drug usage;Education;efficacy testing;Environment;Epidemic;experience;Family;Feedback;Focus Groups;Friends;Future;Goals;Health;Health Personnel;high risk;HIV;HIV Infections;HIV risk;HIV Seropositivity;Human immunodeficiency virus test;illicit drug use;Injecting drug user;innovation;insight;Intervention;Interview;Labor Migrations;Language;Leadership;marginalization;member;Methods;Migrant;Migrant Workers;Modeling;Modification;Moscow;Movement;non-drug;Outcome Measure;peer;Personal Satisfaction;Pharmaceutical Preparations;poor health outcome;Population;Prevention;Process Measure;prototype;recruit;Research;Risk;Risk Behaviors;Russia;Services;social;social culture;Social Network;social stigma;Societies;socioeconomics;Stigmatization;Tajikistan;Testing;Training;transmission process;treatment services;Trust;Unemployment;Work

PROJECT_TITLE: Intersectional Stigma Reduction for Tajik Migrants Who Inject Drugs

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Esophageal Cancer;Health Services;Patient Safety;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative – Public Health Relevance Patients with chronic acid reflux disease are often diagnosed with a precancerous condition called Barrett's esophagus with low-grade dysplasia. This is the “first step” which can sometimes lead to esophageal cancer (a lethal cancer that has increased in incidence over the last five decades). Endoscopic treatments are available to destroy low-grade dysplasia, but these treatments are costly and associated with complications. It is unclear whether patients who develop low-grade dysplasia should undergo these endoscopic treatments, or instead undergo periodic endoscopic surveillance procedures, reserving the endoscopic treatments for only those who develop the more serious high-grade dysplasia or cancer. This study will compare the effectiveness of these two approaches, fundamentally changing the way we manage patients with Barrett's esophagus.

PI_NAMEs: DURKALSKI, VALERIE L;SHAHEEN, NICHOLAS J;SOUZA, RHONDA F;WANI, SACHIN  (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Achievement;Address;Adult;Affect;Area;arm;Barrett Esophagus;biobank;Biological;Biological Markers;biomarker panel;biomarker selection;Biopsy;Caregivers;Caring;Categories;Chronic;Clinical;clinical biomarkers;Clinical Management;Clinical Trials;Clinical Trials Data Monitoring Committees;clinically relevant;cohort;common treatment;comparative effectiveness;comparative safety;compare effectiveness;Complication;Conduct Clinical Trials;cost;Data;design;Detection;Diagnosis;Disease;Dysplasia;Effectiveness;Eligibility Determination;Endoscopy;Enrollment;Ensure;Equipoise;Esophageal Adenocarcinoma;Esophageal mucous membrane;Esophagus;Europe;experience;Feedback;follow-up;Forcep;Funding;Future;Gastroesophageal reflux disease;Goals;Grant;Guidelines;Health;health related quality of life;Healthcare;High grade dysplasia;high risk;Histologic;Image;Immunohistochemistry;improved;Incidence;inclusion criteria;innovation;Institute of Medicine (U.S.);Knowledge;Lead;Malignant neoplasm of esophagus;Malignant Neoplasms;Metaplasia;Modality;Molecular;Morbidity - disease rate;Mucous Membrane;multidisciplinary;Patient Care;patient oriented;patient population;Patient-Focused Outcomes;Patients;Peer Review;Periodicals;Population;Positioning Attribute;Precancerous Conditions;predict clinical outcome;primary endpoint;Principal Investigator;Procedures;Protocols documentation;Public Health;public health relevance;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Research;Research Priority;Risk;risk stratification;Sample Size;Sampling;Specific qualifier value;standard of care;Survival Rate;Time;TP53 gene;Translational Research;treatment center;Treatment Cost;treatment group;tumor progression;United States;Well in self;Work

PROJECT_TITLE: A Multicenter Randomized Controlled Trial of Surveillance versus. Endoscopic Therapy for Barretts Esophagus with Low-grade Dysplasia: The SURVENT Trial


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Maternal Health;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE Identification of effective interventions to improve maternal and infant health is critical to mitigate the enormous threat to human potential in low resource settings due to the syndemic of undernutrition, overweight/obesity, and climate change. Our combined expertise in nutrition, infectious disease, and heat stress will uniquely augment the multi-disciplinary capacity of the Global Network to accelerate development of effective common protocols to reduce adverse health outcomes and build health resilience.

PI_NAMEs: ASTURIAS, EDWIN JOSE;KREBS, NANCY F (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Acceleration;Address;Adverse effects;Air;Area;Azithromycin;Biological;Birth;Body mass index;career development;Child;Child Health;Child Malnutrition;climate change;Clinical Trials;Colorado;Communicable Diseases;Competence;Conceptions;cost effective;COVID-19 surveillance;Development;Discipline of obstetrics;disease stressor;Dose;early pregnancy;effective intervention;efficacy trial;Environment;environmental stressor;evidence base;Exposure to;Fetal Growth;field study;follow-up;food insecurity;Fostering;Funding;Goals;Growth;Guatemala;Guatemalan;Health;Health Policy;Heat Stress;high risk infant;Human;improved;Inequity;Infant;Infant Health;infant morbidity;Infant Mortality;infant outcome;Infection;Information Dissemination;Institution;International;Intervention;Intervention Trial;Iron;Iron deficiency anemia;Lactation;Link;Malnutrition;Manuscripts;Maternal and Child Health;Maternal Exposure;Maternal Health;maternal outcome;member;Mentors;Mentorship;Micronutrients;Mission;mother nutrition;multidisciplinary;neonatal health;neonatal morbidity;neonatal sepsis;neurodevelopment;Newborn Infant;nutrition;Obesity;Observational Study;offspring;Oral;Outcome;Overweight;Panama;pandemic disease;Participant;Perinatal;Pilot Projects;pregnant;Preparation;prevent;Prevention;Productivity;prospective;Protocols documentation;Public Health;Publications;Registries;Research;Research Personnel;resilience;Resource-limited setting;Secure;Sepsis;Services;Site;social;Sustainable Development;syndemic;Temperature;Testing;therapy design;Universities;Vector-transmitted infectious disease;Woman;Zinc;Zinc supplementation

PROJECT_TITLE: Leveraging the Global Network to implement health interventions to improve maternal and child outcomes in a rapidly changing environment


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Lung;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Tobacco;Tobacco Smoke and Health

PHR: Project Narrative Chronic obstructive pulmonary disease (COPD) develops in susceptible smokers over a period of 2-3 decades during which evolving disease remains relatively silent. Although 30-40% of smokers will eventually develop COPD, there are no clinical, physiologic, biologic or molecular measures that identify vulnerable people during the early phase of disease before it can be diagnosed by impaired lung function. The goal of this proposal is to use airway basal stem/progenitor cell dysfunction as a marker to identify vulnerable smokers during early COPD, so that efforts can be focused on primary and secondary prevention, treatments can be developed to slow lung function decline, and early mechanisms of disease can be identified.

PI_NAMEs: GHOSH, MOUMITA ;VANDIVIER, RICHARD W (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Acceleration;Address;Affect;Age;Airborne Particulate Matter;Airway Disease;airway obstruction;Alveolus;Bioenergetics;Biological;Biological Assay;Biopsy;Cause of Death;cell type;Cessation of life;chest computed tomography;Chronic;Chronic Obstructive Pulmonary Disease;cigarette smoke;cigarette smoke-induced;Climacteric;Clinical;cost;Cross-Sectional Studies;Data;Defect;design;Detection;Diagnosis;Diffusion;Disease;Disease Marker;Disease Progression;Disease stratification;disorder control;disorder prevention;Early identification;Energy Metabolism;Enrollment;Environment;environmental tobacco smoke;environmental tobacco smoke exposure;epithelial injury;Epithelium;experimental study;Exposure to;exposure to cigarette smoke;Functional disorder;Gene Expression;Genus Hippocampus;Goals;Histologic;Histology;Impairment;Inferior;Kinetics;late life;longitudinal analysis;longitudinal design;Longitudinal Studies;Lung;Lung Diseases;lung health;lung repair;Maps;Measurement;Measures;Metabolic;metabolomics;Mitochondria;Molecular;Morphology;never smoker;non-smoker;Outcome;Oxidative Phosphorylation;Pathogenesis;Persons;Phase;Physicians;Physiological;Predisposition;Primary Prevention;progenitor;Property;pulmonary function;pulmonary function decline;Pyruvate;Quality of life;Questionnaires;regional difference;Research;resilience;Respiration;respiratory health;Respiratory Signs and Symptoms;response;Risk;Role;Secondary Prevention;self-renewal;Signal Transduction;single-cell RNA sequencing;small airways disease;Smoker;Smoking;smoking cessation;stable isotope;stem cell function;stem cell self renewal;stem cells;Structure;Symptoms;Testing;Vulnerable Populations;X-Ray Computed Tomography

PROJECT_TITLE: Airway Basal Progenitor Dysfunction in the Detection, Progression and Pathogenesis of Early COPD

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


PHR: NARRATIVE FOR THE OVERALL COMPONENT Human papillomavirus (HPV)-related cancers such as cervical and anal cancer occur with an increased prevalence in HIV-positive women and men compared with the general population. The California-Mexico- Puerto Rico (CAMPO) Consortium consists of three Cores and a Clinical Trials Program situated at the Mexican Instituto Nacional de Salud Pública, the Mexican Instituto Nacional de Cancerología, the University of Puerto Rico and the University of California, San Francisco. The Consortium will perform three clinical research studies focused on the prevention of cervical and anal cancer among HIV-positive women and men in Mexico and Puerto Rico. .

PI_NAMEs: ORTIZ, ANA PATRICIA;PALEFSKY, JOEL MICHAEL (contact);SALMERÓN , JORGE

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Adenoviruses;Adult;AIDS prevention;Algorithms;Anus;California;cancer prevention;cancer risk;career;Caribbean region;Cervical;cervical cancer prevention;Cervical Cancer Screening;Cervix Uteri;Clinical;Clinical Research;clinical trial implementation;Clinical Trials;cost effective;Country;Cytology;data management;DNA;Early Diagnosis;Fostering;General Population;Genotype;High Prevalence;HIV;HIV Infections;HIV Seropositivity;HPV-High Risk;Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;Immune response;Immunization Programs;improved;Infrastructure;innovation;interest;Laboratories;Latin America;Latin American;Lesion;Liquid substance;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant Neoplasms;men;men who have sex with men;Mentors;Mentorship;Methylation;Mexican;Mexico;microbiota profiles;Morbidity - disease rate;mortality;next generation;novel;novel strategies;Oncoproteins;Performance;Placebo Control;point of care;Population;Predictive Value;premalignant;Prevalence;Prevention;Probiotics;programs;progression risk;Puerto Rico;Randomized;Research;Research Personnel;research study;Resources;Risk Reduction;Safety;San Francisco;Science;screening;screening program;skill acquisition;Specificity;Squamous intraepithelial lesion;Technology;Testing;therapeutic HPV vaccine;treatment strategy;Triage;Universities;Viral;Woman;women versus men

PROJECT_TITLE: California-Mexico-Puerto Rico Partnership (CAMPO) Center for Prevention of HPV-related Cancer in HIV+ Populations


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Prostate Cancer;Racial and Ethnic Minority Health Research;Radiation Oncology;Social Determinants of Health;Urologic Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: PROJECT NARRATIVE Racial disparities remain prevalent in prostate cancer leading to large differences in incidence and clinical outcomes, with African American men (AAM) experiencing the highest burden of these disparities. Emerging evidence suggests that there are significant immune-oncologic differences in the prostate tumor immune microenvironment (TIME) of AAM compared to European-American men. This proposal seeks to functionally characterize the TIME differences by race and determine the effect on response to immune-modulators, thus opening avenues to identify new therapeutic approaches to improve outcomes in AAM with PCa.

PI_NAMEs: YAMOAH, KOSJ  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: advanced disease;Affect;African American;American;androgen deprivation therapy;Apoptosis;Area;Biochemical;Biological;Biological Factors;Biological Response Modifiers;Biomedical Engineering;Biopsy Specimen;Blood specimen;Cancer Biology;cancer health disparity;Caring;CD8-Positive T-Lymphocytes;Cell Communication;Cell Line;cell type;Cells;Characteristics;Chemotactic Factors;Clinical;Clinical Research;clinically relevant;cohort;Combination immunotherapy;Comparative Genomic Analysis;cytokine;Data;Data Set;differential expression;Disparity;disparity reduction;Distant Metastasis;DNA Damage;DNA Repair;Dose;Epithelial Cells;European;experience;Gene Expression Profile;Gene Expression Profiling;gene repair;Gene set enrichment analysis;Genes;genomic biomarker;Genomics;Goals;health disparity;Immune;immunological intervention;Immunomodulators;immunomodulatory therapies;immunoregulation;Immunosuppression;Immunotherapy;improved outcome;Incidence;Inflammatory;Interferons;Interleukins;Intervention;Investigation;Malignant neoplasm of prostate;Mediating;Mediator;Medical;men;migration;Modeling;novel;novel therapeutic intervention;Operative Surgical Procedures;Organoids;Outcome;Pathway interactions;Patients;Pattern;personalized immunotherapy;Phase;phase 2 study;Phenotype;Play;Population;Prostate;Prostatic Neoplasms;racial difference;racial disparity;racial population;radiation response;Radiation therapy;Radiation Tolerance;Recurrence;Reduce health disparities;Resistance;response;Risk;Role;Sampling;Signal Transduction;Socioeconomic Factors;Socioeconomic Status;Specimen;Stimulator of Interferon Genes;STING1 gene;tertiary lymphoid organ;Therapeutic;Tissues;TNF gene;transcriptome;treatment response;tumor;tumor microenvironment;tumor-immune system interactions;Tumor-infiltrating immune cells;validation studies;whole genome;Work

PROJECT_TITLE: Disrupting the Prostate Tumor Microenvironment in African American Men to Promote Response to Immuno-Modulatory Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]


ORG_CITY: SALT LAKE CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative The cleavage and polyadenylation specificity factor 6 (CPSF6) participates in HIV-1 transcription by controlling the stability of protein phosphatase 2A (PP2A) subunit A. This observation uncovers a novel target for manipulating HIV-1 gene expression via available inhibitors of PP2A, such as LB100, which can be used as therapeutic agents.

PI_NAMEs: PLANELLES, VICENTE  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Biology;cancer type;CDK9 Protein Kinase;Cells;Cleavage And Polyadenylation Specificity Factor;Complex;design;DNA Polymerase II;Effectiveness;experimental study;FDA approved;Gene Expression;Genetic Transcription;HIV;HIV-1;Immune;In Vitro;in vivo;Infection;innovation;Investigation;Mediating;Methods;Minority;Molecular;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Output;Persons;pharmacologic;phosphatase inhibitor;Phosphoric Monoester Hydrolases;Phosphorylation;promoter;Protein Dephosphorylation;Protein phosphatase;Proteins;Proteolysis;Proteomics;Proviruses;reactivation from latency;Regulation;RNA;T-Lymphocyte;Testing;Therapeutic Agents;tool;Transcriptional Regulation;ubiquitin ligase;ubiquitin-protein ligase;Viral;Virus Latency

PROJECT_TITLE: Control of HIV-1 Transcription by CPSF6 and PP2A

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE This project seeks to understand the microbiological origin and clinical significance of "trace-positive" results from a commonly used diagnostic test for tuberculosis. Knowing the risk of current and future tuberculosis in people with this result can help in treating them appropriately and in finding tuberculosis at its earliest stages. People with this result may also provide a unique opportunity to understand early changes that occur in people with tuberculosis as this disease develops or spreads.

PI_NAMEs: KENDALL, EMILY A (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Adolescent;Adult;Age;Bacillus;Biological;Biological Assay;Blood;C-reactive protein;case finding;Cessation of life;Characteristics;Clinical;clinical decision-making;clinically significant;cohort;Communicable Diseases;Communities;community setting;comparative;Coughing;cytokine;Data;design;detection limit;Diagnostic;Diagnostic tests;Disease;Early Diagnosis;Epidemiology;Ethics;Evaluation;Exposure to;Failure;follow-up;Future;Health;high risk;high risk population;HIV;Human immunodeficiency virus test;Image;Immunologics;improved;Incidence;Individual;Infection;Inflammatory;inflammatory marker;insight;Investigation;Laboratories;Learning;lung imaging;Measurement;meetings;Methods;Modeling;Molecular;molecular dynamics;Monitor;Mycobacterium tuberculosis;Notification;Nucleic Acid Amplification Tests;Nucleic Acids;Outcome;Patients;Persons;Play;Population;preference;Prevalence;Process;programs;prospective;Public Health;public health ethics;radiological imaging;rapid diagnosis;Recording of previous events;reduce symptoms;Risk;Role;Sample Size;screening;sex;Sputum;Surveys;Symptoms;Testing;Time;transcriptomics;transmission process;Tuberculosis;Tuberculosis diagnosis;Uganda;unnecessary treatment;Whole Blood

PROJECT_TITLE: Who are the Ultra-positive, culture-negative? Understanding the trajectories of individuals in Uganda with trace M. tuberculosis nucleic acid in sputum

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The hepatitis B virus (HBV) cure agenda is focused on translating knowledge around viral-host interactions to effective new therapies or combinations of therapies that increase the frequency of functional cure. To accelerate the use of emerging cure therapies in people with HBV/HIV coinfection, a precise understanding of the impact of HIV on host control of HBV is needed. Leveraging a well-established hepatitis B research program in Zambia, and unique expertise in the analysis of HBV-specific immunity, we will investigate the role of specific CD4 T cells in the development of HBV functional cure in people with HIV.

PI_NAMEs: LAUER, GEORG MICHAEL;VINIKOOR, MICHAEL JEFFREY (contact)

PROGRAM_OFFICER_NAME: RADKE, JOSHUA BRYAN

PROJECT_TERMS: Acceleration;Acute Hepatitis;Address;Adult;Anti-viral Therapy;antiretroviral therapy;Biological Response Modifiers;Biology;Blood;Blood Volume;CD4 Lymphocyte Count;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Chronic Hepatitis;Chronic Hepatitis B;Clinical;Clinical Trials;co-infection;cohort;Combined Modality Therapy;Data;Development;Disease;Disease Progression;e Antigens;Enrollment;Evolution;Exclusion Criteria;experience;Fine needle aspiration biopsy;Flow Cytometry;Frequencies;Functional disorder;Generations;Heart;Hepatitis B;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Virus;HIV;HIV Infections;Immune;Immune response;Immunity;Immunologics;Immunology;Immunotherapy;In Vitro;Infection;interest;intrahepatic;Investigation;Knowledge;Liver;Liver diseases;Mediating;mortality;National Institute of Allergy and Infectious Disease;Newly Diagnosed;novel;novel therapeutics;nucleoside analog;Outcome;Participant;Patients;Peripheral;peripheral blood;Persons;Pharmaceutical Preparations;Phenotype;Policies;Population;prevent;Primary carcinoma of the liver cells;programs;Recovery;Reporting;Research;response;Role;Safety;Sampling;seroconversion;Site;Southern Africa;T cell response;T-Lymphocyte;Testing;Therapeutic;transcriptome sequencing;Translating;United States National Institutes of Health;Viral;viral DNA;virtual;Virus Diseases;Zambia

PROJECT_TITLE: HBV-specific T cell immunity in HBV/HIV coinfection

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The Polycomb Repressive Complex 1 (PRC1) is a conserved epigenetic regulator that is required for proper development, and its dysregulation is linked to abnormal embryogenesis, various cancers, and neurodevelopmental disorders. Multiple PRC1 subunits interact with RNA, but the role of these interactions in development is unknown. I will employ a new protein-RNA mapping technology as well as acute protein degradation during differentiation of mouse embryonic stem cells to obtain mechanistic insight into the role of PRC1-RNA interactions in regulating cell fate transitions during developmental transitions.

PI_NAMEs: TASCA, JULIA  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Acute;Amino Acids;Architecture;Bar Codes;Binding;Biochemical;Bioinformatics;Cell Lineage;cell type;Cells;Chemicals;ChIP-seq;Chromatin;Chromatin Remodeling Factor;Communication;Complex;Couples;Coupling;crosslinking and immunoprecipitation sequencing;Data;Data Analyses;Dedications;Defect;Deposition;design;Development;differentiation protocol;directed differentiation;Embryo;Embryonic Development;embryonic stem cell;Ensure;Environment;Epigenetic Process;Event;experience;experimental study;functional genomics;Gene Expression;gene repression;Gene Silencing;Gene Targeting;Genes;Goals;Histone H2A;Human;Immunoprecipitation;improved;in vivo;inducible gene expression;insight;Intellectual functioning disability;interest;Investigation;Kidney;Libraries;Link;Lysine;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;Methods;Microcephaly;Molecular;Mouse Embryonic Stem Cells;mutant;Mutation;Nature;nerve stem cell;neural;Neurodevelopmental Disorder;new technology;novel;Peptides;Physiological;pluripotency;Polycomb;PRC1 Protein;protein degradation;protein function;Proteins;Reporting;Research;Resolution;RNA;RNA Binding;RNA Biochemistry;RNA-Protein Interaction;Role;Scanning;skills;stem cells;System;Technology;Testing;Training;Training Programs;transcriptome sequencing;Ubiquitin;Work

PROJECT_TITLE: Exposing the Functional Role of Novel Protein-RNA Interactions in PRC1 During Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Depression;Drug Abuse (NIDA only);Genetics;Mental Health;Mental Illness;Pediatric;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE  Widespread changes in cannabis availability and societal acceptance highlights the importance of characterizing cognition and psychiatric disorder symptoms when regular cannabis users remain abstinent. Results from the proposed experimentally-manipulated discordant twin study will provide evidence to support or contradict a causal model regarding the effects of cannabis abstinence on cognition and psychiatric disorder symptoms. Depending on the results, this study could provide motivation for cannabis users to quit or cut back or help in the identification of individuals who are at-risk for worse cognitive outcomes.

PI_NAMEs: ROSS, JESSICA MEGAN (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Abstinence;addiction;Adolescence;Adolescent;Adult;Anxiety;Attention;Attention deficit hyperactivity disorder;Back;Behavioral Genetics;Candidate Disease Gene;Cannabis;causal model;Clinical Trials;Cognition;Cognition Disorders;Cognitive;cognitive function;cognitive recovery;Colorado;comparison control;contingency management;Control Groups;Controlled Study;Data;design;Diagnosis;Educational workshop;Environment;Environmental Risk Factor;epidemiology study;executive function;gene environment interaction;Genes;Genetic Polymorphism;Genetic Risk;genome wide association study;genome-wide;Genotype;Goals;Health;Household;Impaired cognition;improved;Incentives;Individual;Language;Legal;Maps;marijuana use;marijuana user;Measures;meetings;Memory;Mental Depression;Mental disorders;Mentors;Methodology;Methods;Monitor;Monozygotic twins;Motivation;novel;Older Population;Outcome;Participant;Patients;Pattern;Performance;physical conditioning;Positioning Attribute;Preparation;processing speed;prospective;Protocols documentation;psychiatric symptom;Public Health;Randomized;Randomized, Controlled Trials;Recording of previous events;Recovery;recruit;Registries;Reporting;Research;Research Design;Research Personnel;Research Project Grants;research study;Research Training;Resources;responsible research conduct;Risk;Sample Size;Sampling;skills;Statistical Data Interpretation;Stressful Event;Symptoms;Testing;Training;Training Programs;Twin Multiple Birth;Twin Studies;unethical;Withdrawal

PROJECT_TITLE: Changes in cognition and psychiatric disorder symptoms during cannabis abstinence using a novel discordant twin design

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Our UCSF Stanford Endometriosis Center for Discovery, Innovation, Training and Community Engagement (“ENACT”) is a new collaborative program comprised of an accomplished group of investigators and clinicians in multiple disciplines, as well as educators, trainees, and community representatives who are all committed to improve the lives of women and teen girls with endometriosis. The overall goals of the Center are to understand endometriosis pathogenesis and pathophysiology, develop accurate disease classifications, identify novel therapies, improve patient outcomes, train the next generation in endometriosis research, and engage our community in these efforts to enrich research and to empower those affected.

PI_NAMEs: GAUDILLIERE, BRICE ;GIUDICE, LINDA C (contact);SIROTA, MARINA

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Adaptive Immune System;Address;Affect;Age;analog;Animal Model;Area;Aromatase Inhibitors;Autoimmune;Awareness;Biological Markers;biological specimen archives;Cardiovascular Diseases;career;career development;Cells;Characteristics;Chronic;chronic pelvic pain;Cicatrix;Classification;Clinical;clinical care;Clinical Data;clinical phenotype;clinically relevant;Collaborations;Communication;Communities;community engagement;Community Health Education;Community Outreach;comorbidity;Complex;Computational Science;Contraceptive Agents;Coupled;Data;Databases;Diagnosis;diagnostic biomarker;diagnostic strategy;Discipline;Disease;disease classification;disease diagnosis;disease heterogeneity;Disease Management;disease phenotype;Disease stratification;diversity and inclusion;DNA Library;drug discovery;drug repurposing;Dysmenorrhea;economic impact;Education;Education and Outreach;empowerment;Endometrial;endometriosis;Endometrium;Environment;Environmental Science;Estradiol;Estrogens;Etiology;Excision;Fatigue;Fertility;Fostering;Functional disorder;Genetic;Genomics;girls;GNRH1 gene;Goals;Health;health disparity;health economics;Health Expenditures;Health Professional;Heterogeneity;Hormonal;Human;human tissue;Immunologics;Immunology;improved;Incidence;Infectious Agent;Infertility;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Informatics;Innate Immune System;innovation;Institution;interdisciplinary collaboration;Lesion;Life;Machine Learning;Malignant - descriptor;Malignant Neoplasms;Medical;member;Mental Depression;Mentors;Mentorship;metabolomics;minimally invasive;multidisciplinary;Multiomic Data;multiple omics;next generation;Non-Malignant;Non-Steroidal Anti-Inflammatory Agents;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Organ;Outcome;Pain management;pain relief;pain symptom;Pathogenesis;Pathology;Patient-Focused Outcomes;Pelvic Pain;Pelvis;Peritoneum;persistent organic pollutants;Personal Satisfaction;Pharmaceutical Preparations;Phenotype;phenotypic data;Positioning Attribute;precision medicine;Prediction of Response to Therapy;Pregnancy Outcome;programs;Proteomics;Quality of life;Recurrence;Recurrent disease;Recurrent pain;reproductive;Research;Research Personnel;Research Project Grants;Resolution;Resources;response;Risk;Science;Scientist;Severities;side effect;Steroids;student participation;student training;Surgeon;Symptoms;systemic inflammatory response;Systems Biology;technological innovation;Technology;Teenagers;therapeutic biomarker;Tissue Banks;Tissues;Training;Transcend;transcriptomics;treatment response;United States National Institutes of Health;Universities;Uterus;Validation;Viral;Woman;Women's Health


PI_NAMEs: GIUDICE, LINDA C (contact)

PROJECT_TERMS: Accountability;Accounting;Administrator;Advertising;Area;Award;Awareness;California;clinical investigation;clinically relevant;cohesion;Collaborations;Communication;Communities;community engagement;Community Outreach;community partners;Complex;cost effectiveness;Data;diagnostic strategy;Discipline of obstetrics;disease classification;Doctor of Philosophy;Education;Education and Outreach;empowerment;endometriosis;Ensure;Expenditure;experience;Faculty;Functional disorder;Funding;Goals;Grant;Guidelines;Gynecology;human subject;Immunologics;Infrastructure;innovation;Institution;inter-institutional;Interdisciplinary Study;lens;meetings;member;Mentors;minority student;multidisciplinary;multiple omics;next generation;novel therapeutic intervention;operation;Participant;Pathogenesis;Patients;programs;Regulation;reproductive;Reproductive Health;Reproductive Sciences;Research;Research Personnel;Research Project Grants;Resources;senior faculty;social media;Structure;Talents;Training;training opportunity;Translational Research;underserved minority;United States National Institutes of Health;Universities;Vertebrates;Washington;web site;Woman;Women's Health

PROJECT_TITLE: Administrative Core (Core A)


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Orphan Drug;Patient Safety;Rare Diseases;Rehabilitation

ORG_CITY: PITTSBURGH

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: 8. Project Narrative Brain-Computer Interfaces (BCIs) may enable paralyzed individuals to directly control personal computers and assistive devices to reduce disability and improve independence. The proposed research will test the safety and efficacy of a novel BCI implanted into a blood vessel of the brain and can wirelessly record and transmit neural signals for the control of assistive technologies. The proposed system is being developed for commercialization by a company (Synchron) with the primary goal of addressing unmet public health needs in the area of improving independence and quality of life for people with severe paralysis.

PI_NAMEs: OXLEY, THOMAS J;PUTRINO, DAVID FRANCIS;WEBER, DOUGLAS J (contact)

PROGRAM_OFFICER_NAME: WU, GUANGYING

PROJECT_TERMS: Address;Adverse event;adverse event monitoring;Affect;Amyotrophic Lateral Sclerosis;Animal Model;Animal Testing;Animals;Area;Attention;Australia;Blood Vessels;Brain;brain computer interface;Brain imaging;Caregivers;Caring;Catheters;Cerebrovascular system;Cessation of life;Chronic;Clinical;clinical efficacy;Clinical Trials;commercialization;Communication;Complex;computational platform;Computer software;Computers;Custom;Data;Development;Devices;digital;digital communication;disability;Economics;efficacy outcomes;Electronic Mail;empowerment;Evaluation;experience;Eye;Family;Feasibility Studies;feasibility trial;Feedback;feeding;first-in-human;Friends;functional disability;functional independence;gaze;Goals;Grant;Hand;haptic feedback;Home;Hospitals;Hour;Human;Implant;implantation;improved;Individual;Institutional Review Boards;instrumental activity of daily living;Internet of Things;Learning;Leg;Legal patent;Letters;Locked-In Syndrome;Marketing;Measures;migration;mobile computing;Motor;Motor Cortex;neural implant;Neurodegenerative Disorders;neuroimaging;neurotransmission;New York City;novel;older men;Operative Surgical Procedures;Output;Paralysed;Participant;Pathway interactions;Patients;Personal Computers;Persons;Pharmaceutical Preparations;Phase;physically handicapped;Population;Positioning Attribute;pre-clinical assessment;preclinical safety;preclinical study;programs;Public Health;Quality of life;recruit;remote control;Research;research study;restoration;Safety;safety outcomes;safety study;safety testing;secondary outcome;Self-Help Devices;sensor;Serious Adverse Event;Sheep;Site;smart home;Social isolation;Software Validation;somatosensory;Speech;Speed;Spinal cord injury;standard measure;Stents;Stroke;Superior sagittal sinus;Synaptic Transmission;System;systemic toxicity;Technology;Telemetry;Testing;Therapeutic;Thinking;Thrombosis;Time;Training;Translating;Upper Extremity;User-Computer Interface;visual tracking;Well in self;Wife;wireless;wireless communication;X-Ray Computed Tomography

PROJECT_TITLE: SWITCH Trial: Early Feasibility Study of Stentrode BCI for Augmentative Communication


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative (2-3 sentences) Regulated chemical modification of RNAs is critical for proper gene expression. Most N6-methyladenosine modifications on mRNAs are created by the METTL3/METTL14 complex, and dysregulation of the enzyme has been linked to numerous cancers. The proposed work will discover drug-like small molecules to target undesired METTL3/METTL14 activity to serve as leads for therapeutics and tool compounds for cancer research.

PI_NAMEs: NAM, YUNSUN  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Adenocarcinoma Cell;Affect;anti-cancer research;anti-cancer therapeutic;Attention;Biochemical;Biological;Biological Assay;Biological Process;Biophysics;Cancer Patient;cancer type;carcinogenesis;Categories;Cells;Chemicals;Complex;Consumption;Development;Disease;Dose;Dose Limiting;drug-like compound;Endometrial adenocarcinoma;Enzymes;Exhibits;Future;gain of function;gain of function mutation;Gene Expression;Goals;Growth;high throughput screening;Homocysteine;Hyperactivity;Hypermethylation;inhibitor;insight;Investigational Therapies;Lead;lead optimization;Libraries;Life Cycle Stages;Link;Malignant Epithelial Cell;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Messenger RNA;Methods;Methylation;Methyltransferase;Modification;Monitor;Mus;mutant;Mutate;Mutation;Nature;novel;Oncogenic;overexpression;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Substance;Play;Poison;posttranscriptional;Primary carcinoma of the liver cells;Production;programs;Reaction;response;RNA;RNA Sequences;RNA Splicing;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;screening;Selection Criteria;Site;small molecule;small molecule inhibitor;small molecule libraries;Specificity;Structure;Structure-Activity Relationship;Substrate Specificity;targeted cancer therapy;Testing;Therapeutic;tool;Toxic effect;Translations;tumorigenesis;tumorigenic;Work

PROJECT_TITLE: Small molecules to target the RNA methyltransferase complex METTL3/METTL14

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(56)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Contraception/Reproduction;Endometriosis;Genetics;Human Genome;Pain Research;Precision Medicine;Women's Health Research

PROJECT_TERMS: Adaptive Immune System;Adhesions;Affect;Age;Anatomy;Biological Assay;Biological Process;Cell Communication;Cell Physiology;cell type;Cells;Characteristics;Chronic;Classification;Clinical;clinical care;Clinical Data;Communities;community engagement;Complex;Computational Science;Connective Tissue Cells;Cytometry;Data;Data Sources;Detection;Diagnosis;Diagnostic;Dimensions;Disease;disease classification;disease heterogeneity;Disease stratification;disorder subtype;DNA Library;effective therapy;Endometrial;endometriosis;Endometrium;Environment;Estrogens;eutopic endometrium;Fibrosis;Flow Cytometry;Functional disorder;Genomics;Goals;high dimensionality;Hormonal;Human;Image;Immune;immune cell infiltrate;Immune system;Immunologics;improved;In Vitro;Infertility;Infiltration;Inflammatory;Innate Immune System;innovation;lens;Lesion;Macrophage;Measurement;Mesothelium;Metadata;Microscope;Molecular;Molecular Profiling;multidisciplinary;Myelogenous;novel;Organ;Ovary;Pain;Pathogenesis;Pathology;Pathway interactions;Patients;Pelvic Pain;Pelvis;Peripheral;peripheral blood;Peritoneal;Peritoneum;personalized diagnostics;personalized therapeutic;Phagocytes;Phase;Phenotype;Physicians;Population;precision medicine;predictive modeling;prognostic value;Proteins;Proteomics;Protocols documentation;Quality of life;reproductive;Research;Resolution;response;single cell technology;single nucleus RNA-sequencing;single-cell RNA sequencing;Surgeon;System;systemic inflammatory response;Taxonomy;Techniques;Technology;Testing;Therapeutic Intervention;therapeutic target;therapeutically effective;Tissue Banks;Tissues;Training;transcriptome;transcriptomics;Universities;unsupervised clustering;unsupervised learning;Woman

PROJECT_TITLE: Leveraging Single-Cell Technologies to Elucidate Niche Environments and Immune Mechanisms Involved in Endometriosis Pathogenesis, Pathophysiology, and Disease Stratification


NIH_SPENDING_CATS: Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine

ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Project narrative Genetic discoveries made using individuals of a specific ancestry usually transfer poorly to a different ancestry and are therefore not generalizable. The goal of the proposed research program is to improve the accuracy and generalizability of phenotypic prediction in multi-ancestry samples by quantifying the importance of and accounting for interactions between genes and external contexts such as environmental conditions. This research will provide a novel analytical strategy/methodology that can be applied to any trait of interest and will be a significant advance towards effective and equitable personalized medicine.

PI_NAMEs: MORGANTE, FABIO  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Accounting;Age;Agriculture;Breeding;Complex;Complex Genetic Trait;Data Set;Disease;Equity;European ancestry;Gene Frequency;General Population;Genes;Genetic;genetic analysis;genetic architecture;Genetic Research;genome wide association study;Genotype;Goals;Health;Heterogeneity;Human;human data;improved;Individual;interest;Knowledge;Laboratories;Linkage Disequilibrium;Medical;Mendelian disorder;Methodology;Methods;Modeling;novel;Pattern;personalized medicine;Phenotype;polygenic risk score;Polygenic Traits;precision medicine;predictive modeling;programs;Research;risk variant;Role;Sample Size;Sampling;sex;Socioeconomic Status;Source;Statistical Methods;trait;Variant;Work

PROJECT_TITLE: Understanding and using gene-by-context interactions in human complex trait genetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Maternal Health;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_NAME: LIEBER INSTITUTE, INC.

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because understanding the impact of SARS- CoV-2 maternal infection on pregnancy and infant neurodevelopmental outcomes, and the mechanisms involved, is necessary to inform guidelines and targeted interventions for exposed women and their infants. This knowledge can improve preparedness for future infectious outbreaks that affect the mother and the infant and can help to identify biomarkers of risk for neurodevelopmental disorders in the offspring of women with infection during pregnancy. The proposed research is relevant to NIH’s mission to foster understanding of developmental trajectories affected by important events occurring during pregnancy, paving the way for prevention, recovery, and cure.

PI_NAMEs: URSINI, GIANLUCA  (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: 2019-nCoV;adverse pregnancy outcome;Affect;Age;Age Months;antenatal;Attention deficit hyperactivity disorder;autism spectrum disorder;Biological Markers;Biology;biomarker identification;Birth;Blood Vessels;Brain;Caring;Cerebral Palsy;Child;Child Support;Childhood;Clinical;cohort;congenital infection;Control Groups;COVID-19 pandemic;current pandemic;Data;Decidua Basalis;Development;Discipline of obstetrics;Disease;Disease Outbreaks;Educational Intervention;Environment;Ethnic Origin;Evaluation;Event;Exhibits;experience;fetal;fetal blood;Fetal Development;Fetal Growth;Fetal Growth Retardation;Fever;First Pregnancy Trimester;follow-up;Fostering;Future;Gene Expression;Genes;genomic predictors;Genomics;Gestational Age;Goals;Guidelines;Hospitals;Hyperthermia;immune activation;improved;in utero;Individual;Infant;Infection;Inflammatory;innovation;Intervention;Knowledge;Link;male;Maternal Health;maternal stress;Mediating;Mission;Molecular Biology;Mothers;Neonatal;neurodevelopment;Neurodevelopmental Disorder;Neurology;Newborn Infant;offspring;Outcome;pandemic disease;pandemic response;Pathology;Peptides;perinatal outcomes;Placenta;Placental Biology;placental morphology;post SARS-CoV-2 infection;postnatal;potential biomarker;Pre-Eclampsia;pre-pandemic;Pregnancy;Pregnancy Complications;Pregnancy Histories;Pregnant Women;Premature Birth;prenatal;prenatal exposure;Prevention;preventive intervention;Process;programs;protein expression;Proteins;Proteomics;Psychometrics;Public Health;Readiness;Recovery;recruit;Research;Risk;Risk Factors;RNA;Sampling;SARS-CoV-2 exposure;SARS-CoV-2 infection;SARS-CoV-2 positive;Schizophrenia;Second Pregnancy Trimester;Severities;sex;single-cell RNA sequencing;Stress;symptomatic COVID-19;Testing;Therapeutic Intervention;Tissues;United States National Institutes of Health;unvaccinated;Vaccinated;Vertical Transmission;Virus Diseases;Woman;Work

PROJECT_TITLE: Maternal SARS-CoV-2 infection, placenta biology, and neurodevelopmental outcomes in the offspring

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]