NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE  The cytochrome P450 4F (CYP4F) family are fatty acid -hydroxylases and involved in generating lipid mediators from arachidonic acid, the clearance of drugs, and the metabolism of vitamins and proinflammatory eicosanoids. They are associated with human diseases such as hypertension, cancer, and traumatic brain injury, yet little is known about their cellular function and their structural properties. The Brixius lab proposes in-depth functional and structural studies to unravel their role in cellular processes and their association with human disease using cell biology, biochemistry, and X-ray protein crystallography.

PI_NAMEs: BRIXIUS-ANDERKO, SIMONE  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Acids;Affinity;Amino Acid Sequence;Animal Model;Arachidonic Acids;Architecture;Binding;Biochemistry;blood pressure regulation;Cancer cell line;Catalysis;cell motility;Cell Physiology;Cell Proliferation;Cellular biology;Ceramides;Complex;Crystallography;CYP4F11 gene;Cytochrome P450;Cytochromes b5;Disease;disease model;drug clearance;drug metabolism;Drug Targeting;Eicosanoids;Enzymes;Evaluation;Family;Fatty Acids;Human;Human body;human disease;Hypertension;Individual;Inflammatory;inhibitor;knock-down;Ligand Binding;lipid mediator;lipidomics;Lipids;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Metabolic Pathway;Mixed Function Oxygenases;NADPH-Ferrihemoprotein Reductase;overexpression;Oxidation-Reduction;Pharmaceutical Preparations;Physiology;Production;Property;Protein Isoforms;Proteins;Recombinants;Research;research vision;Roentgen Rays;Role;Structure;Substrate Specificity;Synchrotrons;transcriptomics;Traumatic Brain Injury;Vitamin K;vitamin metabolism;Xenobiotic Metabolism

PROJECT_TITLE: STUDIES ON FATTY ACID METABOLIZING CYTOCHROME P450 ENZYMES


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Patient Safety

ORG_CITY: WORCESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed administrative supplement project builds on the parent grant, “Advancing Geriatrics Infrastructure and Network Growth,” which bridges the Health Care Systems Research Network, and the Claude D. Pepper Older Americans Independence Centers to advance an interdisciplinary research agenda focused on older adults with multiple chronic conditions, including persons living with Alzheimer’s disease. The work undertaken under the proposed supplement will develop and validate a claims-based algorithm for important safety-related events relating to novel therapies for Alzheimer’s disease and create a protocol for data linkages between registries and national health plan administrative data. This work will lay the groundwork for assessing the safety of anti-amyloid therapies for Alzheimer’s disease in real-world settings.

PI_NAMEs: GURWITZ, JERRY H (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: abeta accumulation;Address;Administrative Supplement;Algorithms;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapy;American;Amyloid;Amyloid beta-Protein;Antibodies;Apolipoproteins;Benefits and Risks;Brain Edema;Capsicum;career development;Caregivers;Cerebral hemisphere hemorrhage;Clinical;Clinical Trials;Cognitive;cognitive function;cohort;collaboratory;Confusion;Data;Data Linkages;data platform;data registry;data resource;Data Sources;data submission;Dementia;design;Development;Diagnostic;Dizziness;Electronics;Eligibility Determination;Event;expectation;Fostering;Funding;Future;Generations;Geriatrics;Goals;Grant;Growth;Headache;Health;health care service utilization;health plan;Healthcare;Healthcare Systems;Hemorrhage;high risk;Homozygote;human old age (65+);IgG1;Image;Impaired cognition;Infrastructure;innovation;insight;Interdisciplinary Study;Measures;medication safety;Methodology;Methods;mild cognitive impairment;Monitor;Monoclonal Antibodies;multiple chronic conditions;Nature;Nausea;Neurologic Symptoms;novel therapeutics;older adult;Outcome;parent grant;parent project;Pathologic Processes;patient registry;Patients;Persons;Pharmaceutical Preparations;Placebos;Population Surveillance;Process;protein aggregation;Protocols documentation;Registries;Research;Research Activity;Research Personnel;Risk;Safety;safety assessment;Seizures;Sentinel;success;Surveillance Program;Symptoms;System;systems research;tool;Translational Research;Translations;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;validation studies;Vomiting;Work

PROJECT_TITLE: Developing processes and tools to assess the safety of anti-amyloid treatments for Alzheimer's disease using real-world data


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Rural Health;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative  Telehealth is one of the most promising tools to help increase buprenorphine treatment for people with opioid use disorder (OUD), yet we know little about effectiveness of telehealth compared to traditional in- person care, which limits use and poses a major barrier to developing evidence-based policies and implementing high-quality care. The overall goal of this project is to generate clinical guidance to optimize buprenorphine care by evaluating effectiveness of telehealth-delivered buprenorphine, including for high-need and high-risk populations, using novel target trial methods, and incorporating stakeholder perspectives and expert consensus. This study will use national data from the Veterans Health Administration and Medicaid, encompassing the largest U.S. provider and payer for OUD services, and incorporate novel methods to systematically inform best practices for tele-buprenorphine care.

PI_NAMEs: LAROCHELLE, MARC ;LIN, LEWEI ALLISON (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Address;African American population;Behavioral;behavioral health;Black race;Buprenorphine;buprenorphine treatment;Caring;Chronic;Clinic;Clinical;clinically relevant;Communities;comorbidity;comparative effectiveness;compare effectiveness;Consensus;Consensus Development;COVID-19;Data;data integration;Decision Making;Effectiveness;effectiveness evaluation;Eligibility Determination;evidence base;experience;follow up assessment;Goals;Healthcare;high risk;high risk population;hospitalization rates;Hybrids;improved;Individual;innovation;insight;interest;Intervention;Interview;Joints;Life;Literature;Medicaid;medication for opioid use disorder;Methods;National Institute of Drug Abuse;Nature;novel;opioid mortality;opioid use;opioid use disorder;Outcome;Outcome Assessment;Overdose;Overdose reduction;overdose risk;Patient Care;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Policies;Policy Maker;primary outcome;Process;Protocols documentation;Provider;Public Health;Publications;Quality of Care;Quality of life;racial disparity;Randomized, Controlled Trials;Recommendation;Research Methodology;Risk;rural patients;rurality;Services;Specific qualifier value;stakeholder perspectives;Strategic Planning;Structure;Subgroup;substance use;Techniques;telehealth;tool;treatment disparity;Veterans Health Administration;Visit

PROJECT_TITLE: Evaluating real-world effectiveness of tele-buprenorphine: A mixed-methods study to develop clinical guidance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MADISON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Martell project narrative Technologies that enable the identification of which proteins reside in specific locations inside cells are critical for elucidating biological processes and disease states, including neurodegeneration, pathogenic infection, and cancer. One promising strategy to achieve this goal is proximity labeling (PL), but in order to enhance the sensitivity and specificity of proximal protein detection, improved PL catalysts are needed. We propose that hybrid biological-abiotic PL catalysts developed in our laboratory will enhance both sensitivity and specificity in spatially- resolved proteomic mapping, and we are employing these catalysts in neurons to benchmark their performance against existing methods and establish their broad utility as research tools.

PI_NAMEs: MARTELL, JEFFREY DANIEL (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Address;Amino Acids;Area;Benchmarking;Biological;Biological Process;Biotin;cancer cell;catalyst;Cells;Chemicals;Collaborations;Communities;Data Set;Detection;detection sensitivity;Diffuse;Diffusion;Directed Molecular Evolution;Disease;DNA;Doctor of Philosophy;enzyme substrate;Enzymes;Exhibits;Genetic;Goals;Heme;Hybrids;improved;In Vitro;Infection;interest;Kinetics;Label;Laboratories;Length;Location;Malignant Neoplasms;Mammalian Cell;Maps;Mass Spectrum Analysis;Methodology;Methods;Molecular;nano;nanorod;Nanostructures;Nanotechnology;Nerve Degeneration;Neurons;novel;novel strategies;Pathogenicity;Performance;Peroxidases;Phenols;phenoxy radical;protein function;protein protein interaction;Protein-Protein Interaction Map;Proteins;Proteome;Proteomics;Radial;Reaction;Research;Resolution;scaffold;Sensitivity and Specificity;Shapes;Site;Specificity;Structure;Surface;Synapses;Synaptic Cleft;synthetic construct;System;Technology;Tertiary Protein Structure;three dimensional structure;tool;Tyrosine

PROJECT_TITLE: Diversity Supplement to R01GM150698

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Chimeric antigen receptor (CAR) macrophage therapy offers great promise against solid tumors including glioblastoma (GBM). Our current study proposes an innovative strategy to use exosomes-loaded with mRNA encoding a CAR that targets the epidermal growth factor receptor variant III (EGFRvIII), a mutant receptor expressed in 40% of GBM, to produce CAR macrophages in vivo for GBM immunotherapy. If successful, the results generated from the proposal will pave the way for a new strategy to produce CAR cells in vivo and greatly expand the utility of cell therapy against GBM.

PI_NAMEs: JIANG, WEN  (contact);KIM, BETTY

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: adaptive immune response;Adult;Antibodies;Antigen Presentation;Antigens;antitumor effect;Antitumor Response;Autologous;blood-brain barrier crossing;Bone Marrow;cancer immunotherapy;cancer therapy;CAR T cell therapy;CD47 gene;Cell Therapy;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Complex;Consumption;Cross Presentation;cytokine;design;Dose;Electroporation;Encapsulated;engineered exosomes;Engineering;Epidermal Growth Factor Receptor;Epitope spreading;Exhibits;exosome;experimental study;extracellular vesicles;Face;Failure;Glioblastoma;Hematologic Neoplasms;Human;Immune;immune activation;immune cell infiltrate;immune checkpoint blockade;immune resistance;Immune system;Immunocompetent;Immunologic Stimulation;Immunologics;immunosuppressive macrophages;Immunotherapy;In Vitro;in vivo;ineffective therapies;Infusion procedures;innovation;insight;interest;ITGAM gene;Location;Macrophage;Malignant neoplasm of central nervous system;Maps;Mediating;Membrane;Messenger RNA;mRNA delivery;Mus;mutant;Myelogenous;Myeloid-derived suppressor cells;Nature;novel strategies;Pathway interactions;patient derived xenograft model;Peripheral;Phagocytosis;Phenotype;Population;Pre-Clinical Model;Preparation;Production;protein expression;Proteins;receptor;Receptor Cell;reconstitution;Research;Resistance;Solid Neoplasm;Spatial Distribution;Specificity;success;Surface;T cell infiltration;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;Time;Toxic effect;trafficking;transcriptomics;tumor;tumor growth;tumor heterogeneity;tumor microenvironment;Tumor Suppressor Genes;Variant;Viral Vector

PROJECT_TITLE: Engineering mRNA encapsulated extracellular vesicles for in vivo chimeric antigen receptor macrophage therapy for glioblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (81)]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Mental Health;Microbiome;Nutrition;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Patients with advanced cancer experience substantial prognostic uncertainty, leading to increased psychosocial burden, which, in turn, contributes to worse survival. The proposed research will examine the psychosocial sequelae and their biological and social determinants among patients with advanced (i.e., recurrent) head and neck cancer receiving immunotherapy. Findings from biological determinants will be instrumental in developing individual, personalized, and targeted interventions; those from social determinants will be informative for public health and community-level interventions, with an ultimate goal of using multilevel (combining individual and community) to improve psychosocial outcomes and, subsequently, QOL and long- term survival for those with advanced diseases.

PI_NAMEs: FEDIRKO, VERONIKA ;XIAO, CANHUA  (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: advanced disease;Advanced Malignant Neoplasm;Alcohol consumption;Alcohols;Attention;Bacteria;Behavioral;Biological;Brain;Cancer Patient;Cancer Survivor;Caring;clinical prognostic;Cognition;Communities;community intervention;daily functioning;Data;Development;Diet;Disease;dysbiosis;Eating;experience;Fatigue;FDA approved;Goals;gut microbiome;Head and Neck Cancer;head and neck cancer patient;Health;health disparity;health inequalities;Health Services Accessibility;Housing;Immune;Immune checkpoint inhibitor;Immunotherapy;improved;Individual;Inflammation;Inflammatory;Inflammatory Response;Intervention;Investigation;Length;Life Style;Link;low socioeconomic status;Malignant Neoplasms;Mental Depression;Mucositis;Neighborhoods;Nutrient;Oral cavity;Outcome;Pain;Patients;Peripheral;Pharmaceutical Preparations;Phenotype;physical inactivity;Population;prognostic;psychosocial;Psychosocial Influences;psychosocial outcome;Public Health;Quality of life;Recurrence;Research;restoration;Risk Factors;Role;side effect;Sleep;social;social determinants;Social support;Socioeconomic Status;Symptoms;Time;Tobacco;Tobacco use;Toxic effect;Treatment Side Effects;Uncertainty;Unhealthy Diet;Volatile Fatty Acids;Xerostomia

PROJECT_TITLE: Biological and social determinants of psychosocial sequelae in advanced head and neck cancer survivors receiving immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (M1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Physical Activity;Prevention

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Many neurodegenerative diseases that result in dementia involve misfolded proteins that can cause normal proteins in cells to clump. Recently, injection of these misfolded proteins into the gut of mice have been shown to cause protein misfolding in the brain, suggesting a gut-to-brain transmission route. This proposal investigates if a brain scan can detect brain transmission before symptoms appear, and if the same brain scan can detect the ability of exercise to slow brain spread.

PI_NAMEs: SON, JUNSEOK ;TEE, SUI SENG  (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: 3-Dimensional;Algorithms;alpha synuclein;Alzheimer's disease model;APLN gene;Area;Autophagocytosis;Behavioral;behavioral phenotyping;Behavioral Symptoms;Bicarbonates;Biochemical;Brain;Brain imaging;brain metabolism;Brain scan;brain tissue;Carbon;Cells;Central Nervous System;Characteristics;Clinical;Clinical Trials;Cognition Disorders;Cognitive;Contrast Media;Dementia;Dementia with Lewy Bodies;Development;Disease;Disease Progression;dorsal motor nucleus;Early Diagnosis;efficacy evaluation;Exercise;exercise intervention;experimental study;Future;gastrointestinal symptom;Gastrointestinal tract structure;Grant;Histologic;Hormones;human disease;Image;Imaging Device;imaging modality;Imaging technology;Injections;Intervention;Isotopes;Lewy Bodies;Magnetic Resonance Imaging;Maryland;Measures;Mediator;Metabolic;Metabolic dysfunction;metabolic imaging;Metabolism;metabolomics;Methods;misfolded protein;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Motor;mouse model;Mus;Nerve Degeneration;Neurobehavioral Manifestations;Neurodegenerative Disorders;neuronal metabolism;Neurons;neuroprotection;novel therapeutic intervention;Oxidative Stress;parent grant;Patients;Peripheral;Physical activity;pre-clinical;Pre-Clinical Model;pre-formed fibril;Primates;prognostic;protective effect;protein misfolding;Proteins;Pyruvate;Pyruvate Metabolism Pathway;Research;Resolution;Rodent;Route;sedentary;serial imaging;Serum;Signal Transduction;spatiotemporal;Symptoms;synucleinopathy;TBI Patients;Technology;Testing;Three-Dimensional Imaging;Time;Tissues;tool;Translating;Translations;transmission process;treadmill;Universities;Validation;Work

PROJECT_TITLE: Longitudinal Metabolic Imaging of the Brain in Synucleinopathy

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Cancer;Complementary and Integrative Health;Natural Products

ORG_CITY: EAST LANSING

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Plants, fungi, and bacteria create many natural products with health impacts, such as an�bio�cs, cancer treatments, and metabolic regulators. By conduc�ng molecular simula�ons to model natural products enter and leave cells, and quan�fy binding for these small molecules to the appropriate interac�on partner, we can make these natural products more eﬀec�ve and available at lower cost.

PI_NAMEs: VERMAAS, JOSHUA V. (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Bacteria;Binding;bioactive natural products;Biological;Biological Availability;Biophysics;cancer therapy;Cell Membrane Permeability;cell type;Cell Wall;Cells;cost;Disease;Environment;Excretory function;Free Energy;fungus;Health;Hormone Receptor;Human;in vivo;Industrialization;Laboratories;Ligands;Lignin;lipidomics;Malignant Neoplasms;Measures;Membrane;membrane model;Metabolic;Metabolism;Mitochondria;Modeling;Modernization;Molecular;nanoscale;Natural Products;Paclitaxel;Pharmaceutical Preparations;Plant natural product;Plants;Polymers;Proteins;Research;Sampling;Site;small molecule;Sorghum;Techniques

PROJECT_TITLE: Computational Exploration of Plant Natural Products Bioactivity and Bioavailability in Human Health

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE Drug discovery is expensive and time consuming, and applying computer-based rational design in the early stages can accelerate the process and lower costs. However, computational investigations of carbohydrates, nucleic acids and fluorescent molecules are challenging to simulate without inclusion of complex physics. This proposal aims to combine simulations, high quality automated database generation, and the development of machine learning models in order to understand the binding and behavior of carbohydrate-based heparanase inhibitors as possible anti-cancer drug targets, and the photophysical behavior and connection to structure for fluorescent nucleic acids.

PI_NAMEs: WALKER, ALICE RACHEL (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Acceleration;Affinity;Antineoplastic Agents;Behavior;Binding;Biological;Carbohydrates;chemical property;Complex;Computer Assisted;Computers;Consumption;Correlation Studies;cost;Data Set;Databases;design;Development;Docking;Drug Design;drug development;drug discovery;Drug Targeting;flexibility;Generations;Goals;Heparanase inhibitors;imaging agent;Investigation;Learning;machine learning model;multi-scale modeling;new therapeutic target;Nucleic Acids;nucleobase;Pharmaceutical Preparations;Physics;Polysaccharides;Process;Property;rational design;scaffold;simulation;statistical learning;Structure;Techniques;Time;Work

PROJECT_TITLE: Computational rational design of carbohydrate and nucleic acid drug scaffolds with multiscale dynamics and AI


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Public Health Relevance Statement Dendritic cells (DC) are professional antigen presenting cells that serve critical roles in both innate and adaptive immune responses. This project investigates how DC focally deliver cytokines like interleukin 33 to T cells for shaping the inflammatory vs. anti-inflammatory responses generated within the respiratory mucosa through mechanisms dependent upon the enigmatic pore-forming protein Perforin-2.

PI_NAMEs: HERBERT, DE'BROSKI R (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: adaptive immune response;Anti-Inflammatory Agents;Antigen-Presenting Cells;Automobile Driving;Cell Communication;Cell Death;Cell membrane;Cell Shape;Cells;cytokine;Cytoplasm;Data;Dendritic Cells;Family;FOXP3 gene;GATA3 gene;Genetic Transcription;helminth infection;Human;IFNAR1 gene;Immunity;Inflammatory;Inflammatory Response;Innate Immune Response;Interferons;Interleukin-1;Interleukins;IRF4 gene;ITGAX gene;Membrane;mouse model;Mucous Membrane;Mus;N-terminal;pathogen;Pathway interactions;perforin 2;Population;prevent;protein aminoacid sequence;Protein Secretion;Proteins;public health relevance;Regulatory T-Lymphocyte;respiratory infection virus;Respiratory Mucosa;Role;Signal Transduction;T cell response;T-Lymphocyte;Testing;trafficking;transcription factor;VDAC1 gene

PROJECT_TITLE: Perforin 2 controls unconventional cytokine release from mucosal APC


NIH_SPENDING_CATS: Cancer;Cannabinoid Research;Chronic Pain;Clinical Research;Opioids;Pain Research;Palliative Care;Therapeutic Cannabinoid Research

ORG_CITY: DURHAM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE The proposed study fills a major gap in knowledge about how state medical and adult-use (i.e., recreational) cannabis laws have impacted opioid receipt and pain outcomes in cancer. We will triangulate findings from a quantitative policy evaluation with information from surveys and interviews that explore cancer centers’ implementation of state cannabis laws, physicians’ practices for recommending, and patients’ practices for using cannabis for cancer pain. To inform a rapidly evolving policy landscape—in which states are continuously considering, enacting, or expanding cannabis laws— it is essential to understand how these laws affect pain management practices and outcomes for patients with cancer as one of the largest groups of consumers of therapeutic cannabis.

PI_NAMEs: CHECK, DEVON  (contact)

PROGRAM_OFFICER_NAME: JENSEN, ROXANNE ELAINE

PROJECT_TERMS: active method;Address;Adopted;Adoption;Adult;Advanced Malignant Neoplasm;Affect;Amendment;American;Breast;Cancer Center;cancer pain;Cancer Pain Management;Cancer Survivor;cancer therapy;Cannabis;Cannabis policy;chronic pain management;clinical practice;Clinical Practice Guideline;Colorectal;Consensus;curative treatments;Data;data registry;Data Sources;Databases;Diagnosis;Disease;Disease remission;District of Columbia;Evaluation;experience;Goals;Guidelines;Head and Neck Cancer;Health;health care service utilization;Incidence;Institutional Policy;interest;Interview;Knowledge;Laws;Lead;Legal Status;Life Expectancy;Link;Lung;Malignant Neoplasms;marijuana use;marijuana use disorder;Medical;Medical Marijuana;Medicare;Medicare claim;Methods;neoplasm registry;Oncology;Opioid;opioid sparing;opioid therapy;opioid use;opioid use disorder;Outcome;Pain;Pain management;pain outcome;Palliative Care;Patient-Focused Outcomes;Patients;Physicians;Policies;Policy Analysis;population based;Practice Management;programs;Quasi-experiment;Recommendation;Recreation;Reporting;Research;Role;Sampling;substance use;Surveys;survivorship

PROJECT_TITLE: Impact of State Cannabis Laws on Cancer Pain Management and Outcomes: A mixed-methods study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOLOGY

ORG_NAME: WORCESTER POLYTECHNIC INSTITUTE

PHR: PROJECT NARRATIVE Primary cilia concentrate molecular machinery of all major signaling pathways thus allowing cells to communicate with their environment, and cilia defects cause a spectrum of disorders called ciliopathies. The proposed research is relevant to public health because it aims to identify new genes and map pathways in cilia assembly and post-developmental remodeling. This fundamental knowledge has the potential to facilitate development of therapeutic strategies to manage human conditions caused by anatomical and functional cilia abnormalities.

PI_NAMEs: NECHIPURENKO, INNA  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Address;Anatomy;Award;Bioinformatics;Caenorhabditis elegans;Cell Culture Techniques;Cell Physiology;Cells;Cilia;ciliopathy;Collaborations;Communication;Defect;Development;Disease;Environment;Exposure to;G-Protein-Coupled Receptors;gene conservation;Genes;Genetic;genetic analysis;Genetic Diseases;genetic disorder diagnosis;Goals;GTP-Binding Proteins;Heterotrimeric GTP-Binding Proteins;Human;imaging approach;in vivo;Individual;insight;Knowledge;Mammalian Cell;Maps;Mediating;Modeling;Molecular;Molecular Genetics;Morphogenesis;Morphology;Output;Pathway interactions;programs;Proteomics;Public Health;recruit;Research;Research Personnel;Resolution;response;Signal Pathway;Signal Transduction;Signaling Protein;Stress;therapeutic development;Tissues;trafficking;Training

PROJECT_TITLE: Genetic analysis of signaling pathways in cilia assembly and remodeling

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Hematology;Liver Disease;Rare Diseases

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative This application describes a novel mechanism of liver injury caused by the anti-leukemia drug PEGylated asparaginase (PEG-ASNase) involving drug-induced activation of adipose triglyceride lipase (ATGL) and the onset of adipose tissue lipolysis leading to liver injury. PEG-ASNase is a crucial drug used to cure leukemias; however, its use in adult patients is largely avoided due to its high risk of liver injury, which is hallmarked by the onset of hepatic steatosis. The goals of this project are to elucidate the mechanism of PEG-ASNase-induced liver injury and to identify pharmacological strategies that can prevent PEG-ASNase-induced liver injury, increase ALL survival rates, and extend the therapeutic benefit of PEG-ASNase to adult patients.

PI_NAMEs: FERNANDEZ, CHRISTIAN ANTONIO (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Ablation;Acute Lymphocytic Leukemia;Adipocytes;Adipose tissue;Adult;Adult Acute Lymphocytic Leukemia;allyl sulfide;Amino Acids;antileukemic agent;Apoptosis;asparaginase;Asparagine;Attenuated;Calcium;Cathepsins;Cell Death;Cells;Childhood Acute Lymphocytic Leukemia;Clinical;Data;Dose Limiting;drug induced liver injury;Drug usage;EIF-2alpha;Ensure;Enzymes;Eukaryotic Initiation Factors;Fatty Liver;Genes;Genetic;Goals;Hepatic;Hepatocyte;high risk;Human;in vivo;inhibitor;Knockout Mice;leukemia;Lipase;Lipid Peroxidation;Lipolysis;liver injury;Mediating;Mitogen-Activated Protein Kinases;mouse model;Mus;novel;PAR-2 Receptor;Pathway interactions;Patients;Pegaspargase;Peptide Hydrolases;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;prevent;Production;Prokaryotic Initiation Factor-2;Protein Biosynthesis;Receptors, Adrenergic, beta-3;response;risk mitigation;Survival Rate;Testing;Therapeutic;transcriptome sequencing;Treatment Efficacy;Up-Regulation;Work

PROJECT_TITLE: Mechanistic Study of PEG-asparaginase-Induced Liver Injury

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Chronic Pain;Genetics;Human Genome;Neurosciences;Pain Research;Substance Misuse

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Alcohol-induced analgesia is a phenomenon related to two major public health problems in the US: alcohol use disorder and pain conditions. Alcohol confers analgesic effects in a dose- dependent fashion, but the genes and networks underlying this heritable process are poorly characterized. In this training proposal we will study the genetic aspects of ethanol-induced analgesia in mouse models using the complementary, genome-wide methodologies of behavioral quantitative trait locus mapping, differential gene expression analysis in critical brain regions, and weighted gene co-expression network analysis.

PI_NAMEs: ROGERS, WALKER DAVID (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Absence of pain sensation;Acute;addiction;Address;Affect;Alcohol consumption;alcohol use disorder;Alcohols;Algorithms;American;Analgesics;Animals;antinociception;attenuation;Behavioral;Behavioral Genetics;behavioral phenotyping;behavioral response;Bioinformatics;bioinformatics resource;Biological;Biological Assay;Brain region;Candidate Disease Gene;candidate identification;candidate validation;Characteristics;chronic alcohol ingestion;chronic pain;chronic painful condition;Data;Databases;design;Development;diagnostic criteria;differential expression;Dose;Ensure;Environmental Risk Factor;Ethanol;Event;experience;experimental study;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Modified;gene network;Gene Targeting;Genes;Genetic;genetic architecture;Genetic study;genome wide association study;genome-wide;genomic locus;Genotype;GIRK2 subunit, G protein-coupled inwardly-rectifying potassium channel;Heritability;Human;Hyperalgesia;Inbred Mouse;Informatics;Knockout Mice;large-scale database;Link;Literature;Maps;mechanical allodynia;Mediation;Methodology;midbrain central gray substance;model organism;Molecular;mouse genome;mouse model;Mus;neural circuit;Nociception;Opioid Receptor;overexpression;Pain;Pain management;pain symptom;Pathway Analysis;Pathway interactions;Pattern;Peripheral Nervous System Diseases;Persons;phenomics;Phenotype;Population;Potassium Channel;Prefrontal Cortex;Process;Property;Public Health;Quantitative Trait Loci;Reaction Time;Recombinants;Reporting;Research;response;Risk;Rodent Model;Role;Sampling;Signal Pathway;Source;Symptoms;System;Tissue-Specific Gene Expression;Training;training opportunity;trait;transcriptome sequencing;transcriptomics;trend;United States;Variant;Viral Vector;whole genome;Withdrawal

PROJECT_TITLE: Elucidating causal mechanisms of ethanol-induced analgesia in BXD recombinant inbred mouse lines


NIH_SPENDING_CATS: Health Effects of Indoor Air Pollution;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

ORG_STATE: CA

PHR: Project Narrative Medicinal chemistry has historically been driven, to great positive effect, by organic chemistry. There are, however, medicinal problems that can best be solved by exploiting the unique chemistry of inorganic compounds; this research program will broadly take the approach of identifying and solving such problems. During this award period, the focus of the proposed research program will be on the development of (i) a small-molecule metalloporphyrin-based antidote for carbon monoxide poisoning and (ii) an understanding of the biologically relevant chemistry of the pentavalent antimonial drugs used to treat the neglected tropical disease leishmaniasis.

PI_NAMEs: JOHNSTONE, TIMOTHY CHARLES (contact)

PROJECT_TERMS: Antidotes;Antimony;Area;Award;Biochemistry;Bioinorganic Chemistry;Biological;Biology;Carbon Monoxide;Carbon Monoxide Poisoning;Chemistry;Collaborations;Complex;Data;Development;drug structure;Drug usage;Environment;Exhibits;Foundations;Health;improved;Inorganic Chemistry;insight;Investigation;Iron;Knowledge;Leishmaniasis;Medicine;Metabolic Biotransformation;Metalloporphyrins;Methodology;Methods;Molecular Structure;Narrative Medicine;neglected tropical diseases;Organic Chemistry;Oxygen Therapy Care;Parasitic Diseases;Pharmaceutical Chemistry;Pharmaceutical Preparations;Philosophy;Poisoning;Porphyrins;programs;Property;Research;side effect;small molecule;stem;Structure;success;Techniques;Training

PROJECT_TITLE: Using Inorganic Chemistry to Understand and Solve Health-Related Problems


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Rare Diseases;Tuberculosis

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE The inability to quickly and accurately diagnose tuberculosis (TB) in children and initiate treatment is a major contributor to the high mortality of childhood TB worldwide. This study will identify novel Mtb- and host-derived biomarkers, and determine the best biomarker panels (i.e., biosignatures) that can meet the World Health Organization-recommended diagnostic accuracy thresholds for a TB triage or diagnostic test. If successful, the results will the first step needed to make progress toward addressing the critical unmet need for non-sputum biomarker-based tests for childhood TB.

PI_NAMEs: CATTAMANCHI, ADITHYA  (contact);ERNST, JOEL D.

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: 5 year old;accurate diagnosis;Address;Africa South of the Sahara;bioinformatics pipeline;Biological;Biological Assay;Biological Markers;biomarker discovery;biomarker identification;biomarker panel;biomarker signature;biosignature;Blood;Blood Banks;Cause of Death;Child;Childhood;Clinical;clinical research site;clinically relevant;co-infection;cohort;Communicable Diseases;Consensus;cost;Data;Detection;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic tests;Disease;Enrollment;Evaluation;Failure;field study;Gambia;Gene Expression;Gene Targeting;Genetic Transcription;HIV;HIV Infections;HIV/TB;Human;Immunity;Immunoassay;In Vitro;in vitro Model;in vivo;in vivo Model;Investigation;ion mobility;Knock-out;Machine Learning;Macrophage;Mass Spectrum Analysis;Measurement;Measures;Methods;Modeling;mortality;mouse model;multiple omics;Mus;Mycobacterium tuberculosis;next generation;novel;pathogen;Pathogenesis;Pathway Analysis;Pathway interactions;Performance;Plasma;point of care;point-of-care diagnostics;Post-Translational Protein Processing;Prevalence;Probability;prospective;Prospective cohort;Proteins;Recommendation;Reference Standards;Resolution;ROC Curve;Role;Sampling;South Africa;Specificity;Sputum;success;Symptoms;targeted biomarker;Testing;transcriptomics;Translating;Translational Protein Modification;Translations;Triage;Tryptophan;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;Uganda;United States National Institutes of Health;Urine;Validation;validation studies;World Health Organization

PROJECT_TITLE: Childhood Omics and Mycobacterium tuberculosis-derived BiOsignatures (COMBO) for TB diagnosis in high HIV prevalence settings

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)-R]


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Skin Cancer

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Polyomavirus (PyV) is a DNA tumor virus responsible for causing many debilitating human diseases, ranging from neurological disorders and kidney diseases to cancer. At the cellular level, PyV must target to and enter the host nucleus in order to cause infection. In this proposal, we intend to investigate how the prototype PyV SV40 exploits the actions of two nuclear membrane protein complexes – LINC and NPC – to reach the nucleus enabling infection.

PI_NAMEs: TSAI, BILLY  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Binding;Biochemical;Biological Assay;BK Virus;Cell Nucleus;Cell surface;Cells;Cellular biology;combat;Complex;Coupled;Cystitis;Cytoskeleton;Cytosol;Demyelinating Diseases;DNA Tumor Viruses;DNA Viruses;Endoplasmic Reticulum;Endosomes;Event;experimental study;Family;Foundations;Fractionation;Hemorrhage;Human;human disease;imaging approach;Importins;In Vitro;Infection;insight;Integration Host Factors;JC Virus;Kidney Diseases;knock-down;loss of function;Malignant Neoplasms;Mediating;Membrane Proteins;Merkel cell carcinoma;Merkel Cells;Methods;Modeling;mutant;Nervous System Disorder;Nuclear;Nuclear Envelope;Nuclear Import;Nuclear Pore Complex;nucleocytoplasmic transport;particle;Pathway interactions;Polyomavirus;Polyomavirus Infections;Positioning Attribute;prevent;Process;Progressive Multifocal Leukoencephalopathy;protein complex;Protein Complex Subunit;Proteomics;prototype;reconstitution;Role;Simian virus 40;Skin Neoplasms;Viral;Viral Structural Proteins;virology;Virus

PROJECT_TITLE: Investigating the nuclear entry mechanism of SV40

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Infertility;Women's Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE The gonadotropin surge-induced ovulatory changes include the infiltration of leukocytes into the dominant follicle, implying a significant role of leukocytes in the ovulatory process; however, underlying mechanisms remain elusive. Our pilot single-cell transcriptomic data using human follicular aspirates revealed specific cytokines produced by leukocytes and their corresponding receptors in follicular cells, indicating a collaborative role of leukocytes and follicular cells in successful ovulation. Consequently, the proposed study will characterize leukocyte-derived cytokines and their receptors in the human dominant follicle and elucidate their actions and roles in periovulatory granulosa cells, thereby better understanding the mechanisms of how leukocytes facilitate the ovulatory process and luteal formation in the human ovary and its impact on female fertility.

PI_NAMEs: CHOI, YOHAN  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Acute;Address;Anabolism;Animal Model;antagonist;Anti-Inflammatory Agents;aspirate;Bioinformatics;Cell Cycle;Cell Physiology;Cell Proliferation;Cells;Chronic;cytokine;Cytokine Receptors;Data;Data Set;Development;Dinoprostone;egg;Endometriomas;Etiology;Event;Female;female fertility;Female infertility;Fertility;Fertilization in Vitro;Foundations;Gene Expression;Gene Expression Profiling;Gonadotropins;granulosa cell;Hour;Human;Human Chorionic Gonadotropin;IFNGR1 gene;IFNGR2 gene;IL10RB gene;IL16 gene;IL1R1 gene;IL6ST gene;improved;In Situ;in vivo;Infertility;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;Interferon Type II;Interleukin-10;Interleukin-16;Knowledge;Leucocytic infiltrate;Leukocytes;Ligands;Light;Luteal Cells;Luteinization;male;Malignant Neoplasms;MAPK3 gene;Mediator;Messenger RNA;Metabolic;Metabolism;Micro Array Data;Mitochondria;oncostatin M;Ovarian;Ovary;Ovulation;Ovulation Induction;Ovulation Inhibition;Patients;Persons;Pharmaceutical Preparations;Phase;Phosphopeptides;Phosphorylation;Play;Polycystic Ovary Syndrome;Process;Production;Progesterone;Prostaglandin Production;Proteins;Proteomics;PTGS2 gene;receptor;receptor expression;Recombinant Human Chorionic Gonadotropin;Reproductive Physiology;Research;Role;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;spatiotemporal;Specific qualifier value;STAT3 gene;Steroid biosynthesis;steroid hormone;Supplementation;tandem mass spectrometry;Techniques;theca cell;Therapeutic;Therapeutic immunosuppression;Tissue-Specific Gene Expression;Tissues;TNF gene;TNFRSF1A gene;transcriptome sequencing;transcriptomics;Western Blotting;Woman;women's reproductive health

PROJECT_TITLE: The Impact of Leukocyte-derived Cytokines on Ovulation in Humans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-C (02)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative While expression engineering tools have great potential to enhance fundamental science and medicine, the lack of effective ways to control their activity limits their utility. We aim to generate a deeper understanding of transduction mechanisms that could fill this need and use these insights to design better expression control tools.

PI_NAMEs: KHAKHAR, ARJUN  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Agonist;Architecture;Biology;Biosensor;Catalysis;Catalytic RNA;cell type;Chemicals;Cues;design;Devices;Effectiveness;Engineering;G-Protein-Coupled Receptors;Gene Expression;Genes;Genetic Transcription;Genotype;Goals;high throughput screening;Human;inducible gene expression;insight;Kinetics;Ligands;Machine Learning;Medicine;Messenger RNA;Methods;Mission;Molecular;Mutation;National Institute of General Medical Sciences;novel;Nuclear;Nuclear Receptors;Nuclear Structure;Pathology;Phenotype;plant metabolites;programs;Regulation;Research;response;RNA;RNA Splicing;Safety;Science;Signal Transduction;Specificity;Structure;synthetic biology;System;Therapeutic;tool;trafficking;transcription factor;Transcriptional Regulation;Work;Yeasts

PROJECT_TITLE: Elucidating Mechanisms and Design Principles for Chemically Inducible Expression Modulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-F (55)]


ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative This research program aims to develop a chemical proteomic platform for the investigation of extracellular proteinaceous cysteines. Using this pioneering platform, our goal is to decipher the complex landscape of reactivity among extracellular proteinaceous cysteines and leverage these cysteine sites for functional applications.

PI_NAMEs: ZHANG, XIAOYU  (contact)

PROJECT_TITLE: Chemical proteomic mapping and functional manipulation of extracellular proteinaceous cysteines

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: NARRATIVE – PARENT GRANT Intestinal parasites, including soil-transmitted helminths (STH), infect over 1.5 billion people worldwide, resulting in a massive global burden of disease. Mass drug administration (MDA) to high risk populations is the cornerstone of the global strategy for controlling STH infections; however, varied MDA program success indicates that re-infection from environmental reservoirs is common. This proposal leverages a novel, sensitive and specific molecular assay to detect STH DNA in large volumes of soil within a multi-country community-wide MDA randomized controlled trial to define, for the first time, the impact of an MDA intervention on soil reservoirs of STH, and to evaluate the potential for using soil STH DNA as a non-invasive surveillance tool to monitor human infection prevalence.

PI_NAMEs: AJJAMPUR, SITARA SWARNA RAO;IBIKOUNLÉ, MOUDACHIROU ;PICKERING, AMY J. (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Adherence;Affect;Albendazole;Area;Biological Assay;burden of illness;Collection;Communities;cost comparison;cost effective;Country;Data;detection method;Diagnostic;DNA;egg;Evaluation;Feces;field study;helminth infection;Helminths;high risk population;Home;Human;Human Activities;improved;India;Individual;Infection;infection rate;Intervention;Intestinal parasite;Intestines;Laboratory Study;Location;Methods;Molecular;Monitor;novel;parent grant;Persons;Pharmaceutical Preparations;Prevalence;programs;Randomized, Controlled Trials;Resistance;Sanitation;Schools;Soil;soil sampling;stool sample;Study models;success;Testing;Time;tool;transmission process;Water

PROJECT_TITLE: Diversity Supplement - Environmental surveillance of albendazole resistance markers in human infective helminths using dual amplicon metabarcoding


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Pulmonary vascular remodeling is a critical hallmark of Pulmonary Arterial Hypertension. Nicotinamide phosphoribosyltransferase (NAMPT) has been shown to promote pulmonary vascular remodeling, and its inhibition can be a potential therapeutic target. The proposed research will seek to elucidate cellular and metabolic mechanisms governing how NAMPT contributes to PAH pathobiology via metabolic reprogramming mediated pulmonary vascular remodeling.

PI_NAMEs: MACHADO, ROBERTO F. (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Acetylation;Animal Model;Apoptosis;Attenuated;Biological Assay;Cessation of life;Characteristics;Deacetylase;Endothelial Cells;endothelial dysfunction;Ensure;Environment;Enzymes;Evaluation;experimental study;Functional disorder;Gene Expression;Genus Hippocampus;Glycolysis;Harvest;hemodynamics;Homeostasis;Human;Impairment;improved;in vivo;Inflammatory;Knockout Mice;Manganese;Mediating;Membrane Potentials;Metabolic;Mitochondria;mitochondrial membrane;Modeling;Mus;nicotinamide phosphoribosyltransferase;overexpression;Oxidative Stress;particle;Pathogenesis;Pathologic;pharmacologic;Phenotype;Production;Prognosis;Proteins;pulmonary arterial hypertension;Pulmonary arterial remodeling;pulmonary artery endothelial cell;Pulmonary artery structure;pulmonary vascular remodeling;Reactive Oxygen Species;Research;Resistance;Right Ventricular Hypertrophy;Signal Transduction;Sirtuins;Superoxide Dismutase;Systolic Pressure;targeted treatment;Therapeutic;therapeutic target;Vascular remodeling;Vasomotor;Ventricular;Warburg Effect

PROJECT_TITLE: NAD-dependent Signaling and Pulmonary Vascular Remodeling in PAH

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

PHR: PROJECT NARRATIVE Despite the advancements in the management of propionic acidemia (PA) through dietary interventions, patients with PA still experience complications, and there is currently no effective drug treatment available. In this project, we propose to explore the potential of using triacetin to rebalance the acetyl-CoA/propionyl-CoA ratio for the treatment of PA. The anticipated outcome of this project is to enhance the therapeutic effectiveness of PA management, increase tolerance to dietary protein intake, and reduce the complications associated with a low- protein diet.

PI_NAMEs: CHEN, XIAOXIN LUKE;ZHANG, GUOFANG  (contact)

PROGRAM_OFFICER_NAME: PITTENGER, STEVEN THEODORE

PROJECT_TERMS: absorption;Acetates;Acetic Acids;Acetyl Coenzyme A;Adverse reactions;Affect;Amino Acids;Ammonium;carnitine supplementation;Cells;Clinical Trials;Coenzyme A;Data;Diet;Dietary Intervention;Dietary Proteins;dietary restriction;Disease;drug development;effective therapy;Effectiveness;efficacy evaluation;Energy Metabolism;Equilibrium;Esters;Evaluation;Exhibits;experience;FDA approved;Fibroblasts;Food Additives;Future;gene therapy;Genes;Genetic Transcription;Glycerol;Goals;gut microbiome;Hepatocyte;HepG2;Histologic;Histone Acetylation;Human;Hyperammonemia;improved;In Vitro;in vivo;insight;Isoleucine;ketotic hyperglycinemia;Knockout Mice;Life;Lipids;Metabolic;Metabolic Diseases;Metabolism;Methionine;methylmalonyl-CoA decarboxylase;Modeling;Monitor;mouse model;Mus;mutant;Mutation;Myocardial dysfunction;novel therapeutics;Outcome;Pathology;Pathway interactions;Patients;pharmacokinetics and pharmacodynamics;Pharmacotherapy;Phase;Phenotype;Plasma;prevent;Propionates;propionyl-coenzyme A;protein intake;Protein-Restricted Diet;Secure;Supplementation;Systemic Therapy;Testing;Therapeutic;therapeutic effectiveness;therapy development;Threonine;Tissues;Transgenic Organisms;Treatment Efficacy;Valine

PROJECT_TITLE: Triacetin Treatment for Propionic Acidemia by Rebalancing the Acetyl-CoA/Propionyl-CoA Metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-1 (01)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative Defects in synaptic structure and function are often associated with developmental disorders and diseases such as addiction, autism, neuropathic pain, and Alzheimer’s. By defining basic mechanisms controlling synapse density and NMDAR synaptic localization, our proposed research will promote understanding of the molecular and cellular mechanisms that mediate these events and should provide new insights into the pathology of and potential therapies for disease such as addiction.

PI_NAMEs: DALVA, MATTHEW B (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: addiction;Addictive Behavior;Address;Alzheimer's Disease;Architecture;Area;autism spectrum disorder;bassoon protein;Brain;Cells;Cellular Morphology;Chemicals;Color;Communication;Data;Defect;Dendritic Spines;density;developmental disease;Disease;DLG4 gene;Ephrin-B3;Epilepsy;Event;experience;experimental study;Generations;Glutamate Receptor;Health;Human;insight;Label;Learning;Link;Logic;Maintenance;Mediating;Memory;Methods;Molecular;molecular dynamics;Morphology;nano;nanoarchitecture;nanoscale;Nervous System;neural circuit;Neurons;neurotransmitter release;NMDA receptor A1;novel;Pain;painful neuropathy;Pathologic;Pathology;Pattern;postsynaptic;postsynaptic density protein;presynaptic;Presynaptic Terminals;Process;Proteins;reconstruction;Research;Scaffolding Protein;Shapes;Site;Societies;Spinal Anesthesia;Structure;superresolution imaging;superresolution microscopy;Synapses;Synaptic plasticity;Synaptic Transmission;synaptogenesis;Synaptophysin;synaptotagmin I;synaptotagmin VII;Testing;Vertebral column;Visualization

PROJECT_TITLE: Cell-Contact Mediated Mechanisms Assembling Synapses (R01DA022727)


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Hematology;Immunotherapy;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Our proposed clinical trial addresses the significant challenge of relapse prevention post-allogeneic hematopoietic cell transplantation (alloHCT) by introducing a novel strategy that simultaneously suppresses graft-versus-host disease (GVHD) and enhances graft-versus-leukemia (GVL) effects. Utilizing a pioneering combination of post-transplant cyclophosphamide (PTCy) with sirolimus and VIC-1911, an oral selective Aurora kinase A inhibitor, the study aims to harness the benefits of selective immune modulation while eliminating the broad immune suppression of tacrolimus and mycophenolate mofetil. This innovative approach aims to establish a new standard for GVHD prophylaxis that reduces the risks of both GVHD and relapse, leveraging the University of Minnesota’s longstanding and productive collaboration with the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) to accomplish this goal.

PI_NAMEs: EBENS, CHRISTEN LAYNE;JUCKETT, MARK  (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Accounting;Acute;Acute Graft Versus Host Disease;Address;Adult;Affect;Aftercare;Allogenic;antitumor effect;arm;aurora kinase A;Blood;Bone Marrow Transplantation;Calcineurin inhibitor;CD28 gene;Cells;Chimeric Proteins;chronic graft versus host disease;Clinical Trials;Clinical Trials Network;Collaborations;conditioning;CTLA4 gene;curative treatments;Cyclophosphamide;Data;Disease;disorder risk;Dose;Effectiveness;Ensure;Evaluation;experience;Failure;first-in-human;Future;Genetic;Goals;graft vs host disease;graft vs leukemia effect;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;human data;Immune;Immunologics;immunoregulation;Immunosuppression;Impairment;improved;Incidence;Infrastructure;inhibitor;innovation;Institution;Malignant - descriptor;Minnesota;Mission;Molecular;mortality;mouse model;mTOR Inhibitor;mycophenolate mofetil;neoplastic cell;novel;novel strategies;Oral;Pathway interactions;patient population;Patient-Focused Outcomes;Patients;Peripheral Blood Stem Cell;personalized therapeutic;Phase;Phase II Clinical Trials;phase II trial;post-transplant;PPP3CA gene;pre-clinical;preservation;prevent;Productivity;profiles in patients;Prophylactic treatment;Randomized;receptor function;Regimen;Regulatory T-Lymphocyte;Relapse;relapse prevention;Resources;Risk;Role;Route;Safety;side effect;Signal Transduction;Sirolimus;Source;success;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Tacrolimus;Testing;Therapeutic;Transplantation;trial comparing;Universities

PROJECT_TITLE: BMT CTN Core - University of Minnesota

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (M1)]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Nutrition

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Eosinophilic esophagitis (EoE) is an allergic disease of the esophagus partially mediated by epithelial barrier breach, resulting in normally harmless antigens penetrating the underlying tissues, encountering immune cells, and initiating allergic responses. We uncovered that the aryl hydrocarbon receptor (AHR) acts as a sensor molecule that in response to divergent environmental signals can maintain epithelial homeostasis or elicit innate immune response. Thus, we suggest that AHR plays a key role in EoE pathogenesis.

PI_NAMEs: AZOUZ, NURIT P (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: 3-Dimensional;Agonist;Air;Allergic;Allergic Disease;allergic response;Anti-Inflammatory Agents;Antigens;Area;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Biology;Cell Line;Cell Nucleus;Cells;conditional knockout;Data;Dependence;Development;Diet;dietary;Differentiated Gene;Disease;Environment;Environmental Risk Factor;Enzymes;Eosinophilia;Eosinophilic Esophagitis;Epithelial Cells;Epithelium;Equilibrium;Esophageal Diseases;Esophagus;Exposure to;Food;Generations;Genetic Transcription;Health;Homeostasis;Human;Hypersensitivity;Immune;Immunity;in vivo;Inflammation;Inflammatory Response;Innate Immune Response;insight;Intervention;Life Style;Ligands;Mediating;microbiome;microbiota metabolites;Modeling;Molecular;mouse model;Mus;Nature;Outcome;Oxazolone;Particulate Matter;Pathogenesis;Pathology;Pathway interactions;Penetration;pharmacologic;Play;Prevalence;Probiotics;Process;Production;Protease Inhibitor;Proton Pump Inhibitors;Reaction;receptor;Receptor Activation;Receptor Signaling;Research;response;Role;sensor;Signal Pathway;Signal Transduction;Source;Stimulus;Stratified Epithelium;Testing;Tissues;toxicant;transcription factor;Transcriptional Activation;Tryptophan;Tryptophan Metabolism Pathway;Xenobiotics;Zinc;Zinc deficiency

PROJECT_TITLE: Mechanisms of aryl hydrocarbon receptor control of eosinophilic esophagitis

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Sleep Research;Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative This proposed study is designed to be an ancillary study to investigate the impactof prenatal and postnatal factors flame-retardant exposure on sleep health, neurodevelopment, and in children social determinants of health . Ms. Kelli Williams will be involved with the research group in the design, conduct, and analysis of research data for flame-retardant exposures in children as an ancillary study. She has significant interest in increasing diversity in research and can provide her expertise through her background and dynamic educational training on social determinants of health combined with her budding data computational skillset.

PI_NAMEs: CHEN, AIMIN  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Affect;Ancillary Study;Animals;Behavioral;Birth;career;Chemicals;Child;Cognition;cohort;Cohort Studies;Data;design;Disease Outcome;Doctor of Philosophy;Enrollment;environmental chemical;Environmental Epidemiology;Epidemiology;epidemiology study;Esters;experience;Flame Retardants;Funding;Goals;Grant;Health;Human;Hyperactivity;Impaired cognition;improved;innovation;interest;Knowledge;Link;Mediating;Mediation;Memory;Mental Health;Mentors;Minority;Modification;neurobehavior;neurodevelopment;neuroimaging;neurotoxicity;Organophosphates;Particulate;Pennsylvania;polybrominated diphenyl ether;Population;postnatal;Pregnancy;prenatal;Process;programs;prospective;psychosocial development;Research;Role;skills;Sleep;Sleep disturbances;sleep health;social determinants;social health determinants;Techniques;Toxic Environmental Substances;Training and Education;Underserved Population;United States National Institutes of Health;Universities

PROJECT_TITLE: Impact of pre- and postnatal chemical mixture exposures on child neurobehavior and neuroimaging


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Ineffective wound repair following tissue injury results in scarring and loss of important organ functions that can have devastating consequences. Here, we focus on addressing fundamental gaps in our understanding of the molecular mechanism involved in poor wound repair outcomes. Successful completion of this project will lead to new strategies for effective regeneration of tissue injuries.

PI_NAMEs: O'SHEA, TIMOTHY MARK (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Address;Adult;Antimitotic Agents;Astrocytes;Biocompatible Materials;Body System;Cell Communication;Cells;Central Nervous System;Cicatrix;Competence;copolymer;Growth Factor;Hydrogels;improved;In Vitro;in vivo;Injectable;Injury;insight;Knowledge;Lesion;Liver;Mammals;Metabolic;Mitotic;Modeling;Molecular;Mus;Natural regeneration;neonate;Newborn Infant;Nucleosides;Organ;Organ Model;Outcome;Population;postnatal development;Process;Recovery;recruit;Regulation;repaired;self-renewal;Signal Transduction;Spinal cord injury;Testing;tissue injury;tissue regeneration;Tissues;Work;wound healing

PROJECT_TITLE: Regulating parenchymal repair in wound healing


NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE Cells deform their shape to extend protrusions. Protrusions are essential to processes ranging from immune surveillance to cancer metastasis. This project will construct and apply a framework to investigate the molecular regulation of 3D protrusion function.

PI_NAMEs: DRISCOLL, MEGHAN KATRIEN (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 3-Dimensional;Algorithms;Biochemical;Biochemical Pathway;Cell membrane;Cell Physiology;Cell Shape;Cell surface;Cells;Cellular biology;Cellular Morphology;Chemicals;Computational Geometry;computational pipelines;computer science;Computing Methodologies;Coupling;Cytoskeleton;Data Set;Dedications;Feedback;Fluorescence Microscopy;Genetic;Geometry;Image;Immunologic Surveillance;in vivo;Intervention;Investigation;mathematical sciences;Measures;meter;microscopic imaging;Molecular;Movement;Neoplasm Metastasis;Pharmacologic Substance;polymerization;Polymers;Process;Proteins;Regulation;Research;Scientist;Shapes;Signal Transduction;spatiotemporal;Surface;Techniques;Time;Visualization;Work

PROJECT_TITLE: Investigating the molecular regulation of cell protrusion function in 3D


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Rehabilitation;Social Determinants of Health;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative After a fall-related trauma, evidence indicates older adults living with Alzheimer’s disease and related dementias (ADRD) spends substantially less time at home after injury than those without ADRD; however, there are currently few useful tools to help clinicians prognosticate home time for patients with ADRD. Thus, the overall objectives of this administrative supplement expand meaningfully on the parent grant research and career development goals supporting additional research and training to 1) develop, validate, and assess the equity of a predictive tool designed to help clinicals prognosticate home time for older adults following fall- related trauma, and 2) determine how older adults living with ADRD, their care partners, and clinicians caring for them could best utilize these predictions to guide care decisions. Using prediction model outputs as a starting point, this project will inform an R01 testing tailored care pathways based on these predictions to optimize home time for older trauma survivors living with ADRD.

PI_NAMEs: FALVEY, JASON RAYMOND (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Administrative Supplement;Admission activity;aging in place;Alzheimer's disease patient;Alzheimer's disease related dementia;Applications Grants;Area;Baltimore;Biometry;Calibration;career development;Caring;Clinical;clinical practice;Collaborations;community engagement;Consensus;Data Set;Dementia;deprivation;design;Development;Discrimination;economic disparity;Elderly;Equity;Failure;fall injury;fall risk;falls;frailty;Future;Geography;Gerontology;Goals;health disparity populations;Heterogeneity;Hip Fractures;Home;Hospitals;indexing;Injury;Life;Maryland;Mentors;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;Municipalities;Neighborhoods;Nurses;Nursing Homes;older adult;Outcome;Output;parent grant;Parents;Pathway interactions;patient subsets;Patient-Focused Outcomes;Patients;Performance;Population;precision medicine;predictive modeling;predictive tools;prognostication;programs;Publications;Qualitative Research;Race;Recovery;Rehabilitation therapy;Research;research and development;Risk;Services;shared decision making;Socioeconomic Status;Subgroup;Surgeon;Survivors;Testing;Time;tool;tool development;Training;Translating;Trauma;Trauma recovery;Traumatic Brain Injury;Traumatic injury;Universities;Work

PROJECT_TITLE: The ENRICH Study: Engaging Community and Municipal Services to Promote High Quality Aging in Place After Hip Fracture


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Cardiovascular;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE In view of the ongoing threat of mass casualties due to radiological accidents or nuclear terrorism, there is an urgent need for blood assays that determine radiation exposure and predict injuries that may follow. This joint project aims to develop a novel multi-component blood assay that reconstructs absorbed radiation dose and at the same time predicts injury in the heart, one of the organs at risk for long-term loss of function due to radiation exposure. This work will create a novel concept for minimally invasive assays that streamline treatment decisions for victims of a nuclear event.

PI_NAMEs: BOERMA, MARJAN  (contact);CHEEMA, AMRITA KAUR

PROGRAM_OFFICER_NAME: VEDAMONY, MERRILINE M

PROJECT_TERMS: absorption;Acute;Age;Algorithms;Animal Model;Animals;Arkansas;biodosimetry;Bioinformatics;Biological Assay;Biological Markers;biomarker development;biomarker panel;Biometry;Blood;Blood specimen;Body System;Cardiac;Classification;Clinical;Data;design;Development;Doctor of Philosophy;Dose;Early treatment;Echocardiography;Exposure to;falls;FDA approved;feasibility testing;feature selection;Female;General Population;Goals;Heart;heart function;Heart Injuries;Histopathology;improved;in vivo;Individual;Infrastructure;Injury;innovation;Interdisciplinary Study;Ionizing radiation;irradiation;Joints;Knowledge;Leg;Leukocytes;Life;Longitudinal Studies;loss of function;Machine Learning;machine learning framework;machine learning model;machine learning prediction;male;mass casualty;Measurement;Medical;metabolomics;minimally invasive;Modeling;Molecular;multimodal data;multiple omics;novel;Nuclear;Nuclear Accidents;Nuclear Warfare;Organ;organ injury;Output;peripheral blood;Plasma;predictive panel;predictive test;protein biomarkers;Proteins;Radiation;radiation absorbed dose;Radiation Accidents;Radiation Dose Unit;Radiation exposure;Radiation Injuries;Radiobiology;Radiology Specialty;Rattus;reconstruction;Risk;Roentgen Rays;Sampling;Science;System;targeted biomarker;Techniques;Terrorism;Time;tissue injury;tool;Triage;Universities;Work;young adult

PROJECT_TITLE: Development of a minimally invasive biomarker assay to detect delayed radiation injury


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Tourette Syndrome

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NIMH Diversity Supplement Parent grant: 5R01MH130609-02 Principal Investigator: Christopher Pittenger MD PhD Trainee: Enock B. Teefe MD PROJECT NARRATIVE: Obsessive-Compulsive Disorder (OCD) and tic disorders, including Tourette Syndrome (TS), are debilitating neuropsychiatric conditions with few effective treatments. This research project integrates neuroimaging and genetic techniques to deepen our understanding of the genes and neural pathways contributing to these disorders. This is crucial for public health, as it enhances our foundational knowledge of the root causes of OCD and tic disorders, potentially unveiling new treatment avenues to lessen the impact of these conditions.

PI_NAMEs: PITTENGER, CHRISTOPHER JOHN (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Adult;Affect;Autopsy;Basal Ganglia;Binding;Brain;career;Complex;Data;data integration;Development;Disease;Doctor of Philosophy;Dopamine;dopamine D3 receptor;Dopamine Receptor;DRD2 gene;effective therapy;Functional disorder;Ganglia;Gene Expression;Genes;Genetic;genetic risk factor;Genetic Techniques;genetic variant;Genetic Variation;genome sequencing;Gilles de la Tourette syndrome;Human;imaging genetics;indexing;innovation;Investigation;Knowledge;Mentors;Multiomic Data;National Institute of Mental Health;neural circuit;Neural Pathways;neurogenetics;neuroimaging;neuropsychiatry;novel;Obsessive-Compulsive Disorder;parent grant;Participant;polygenic risk score;Positron-Emission Tomography;Principal Investigator;Productivity;Public Health;receptor binding;Receptor Gene;Research;Research Project Grants;Signal Transduction;skills;targeted treatment;Testing;Therapeutic Intervention;Tic disorder;Training;whole genome

PROJECT_TITLE: Dysregulation of dopamine receptors in the basal ganglia in OCD and tic disorders: Positron Emission Tomography with [11C]-PHNO


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Narrative. Communication between the lymph node and the organs it drains is imperative for predicting immune responses to vaccination, infection, and chronic disease, but have been difficult to study in vivo or in vitro. To address this gap, we will develop a user friendly, microscale system specifically co-culture intact samples of live tissue from the lymph node with other organs and allow recirculating of white blood cells between them as occurs in vivo. After determining the effects of various modes of fluid motion on intact lymph node tissue for the first time, we will generate a simple model the response of the lymph node to vaccination, as a proof-of-principle of this new system for modeling multi-tissue immunity outside the body.

PI_NAMEs: POMPANO, REBECCA R (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: 3D Print;Address;Air;Arthritis;Autoimmunity;Biological Models;Biomedical Research;Brain;Cell Culture Techniques;Cells;Chronic Disease;Circulation;Coculture Techniques;Communication;Communities;cooking;design;Disease;Drainage procedure;Ensure;Event;fighting;fluid flow;Hybrids;immune function;Immune response;Immunity;Immunologist;Immunology;Immunosuppression;Immunotherapy;In Vitro;in vivo;Incubators;Infection;Joints;Laboratories;Lateral;Leukocytes;Liquid substance;Lymph Node Tissue;lymph nodes;Lymphocyte;lymphoid organ;Magnetism;microdevice;Microfluidics;miniaturize;Modeling;Molecular;Motion;Organ;Organ Culture Techniques;Perfusion;Peripheral;predicting response;preservation;prototype;Public Health;Pump;Research Personnel;response;Sampling;scale up;Series;simulation;Skin;Slice;System;Testing;Time;Tissue Microarray;Tissues;tumor;Tumor Immunity;user-friendly;Vaccination;Vaccine Design;vaccine immunogenicity;Vaccines

PROJECT_TITLE: Multi-organ culture and pumping systems for ex vivo models of immunity in hybrid tissue-chips


NIH_SPENDING_CATS: Aging;Genetics

PHR: PROJECT NARRATIVE Disruption of the enzymes that write and erase DNA methylation is associated with numerous diseases, including cancers. Despite their fundamental importance, the genetic mechanisms that regulate methylation writer and eraser genes during development remain poorly understood. We will uncover the mechanisms that regulate writer and eraser genes over the cell cycle and during tissue and organ development, as well as during tissue aging.

PI_NAMEs: WILLIAMS, BEN  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: age related;Aging;Arabidopsis;Biological Models;Cell Cycle;Cell Cycle Regulation;Cell division;Cells;Development;Disease;Dissection;DNA;DNA Methylation;Ensure;Environment;Enzymes;Epigenetic age;Epigenetic Process;epigenetic regulation;Failure;Gene Expression Regulation;Gene Silencing;Genes;Genetic;Genomic Imprinting;Goals;Health;Homeostasis;Human;Inherited;insight;Knowledge;Laws;loss of function mutation;Malignant Neoplasms;Methylation;methylation pattern;Modification;organ growth;organ regeneration;Tissues;Trans-Activators;transcription factor;Writing

PROJECT_TITLE: Identifying mechanisms underpinning epigenetic homeostasis

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Endocrine Disruptors;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Environmental exposure to neurotoxicants including pesticides is strongly linked to the etiology of Alzheimer’s disease, yet the mechanisms by which these exposures contribute to Alzheimer’s pathology and neurodegeneration remain poorly understood. Building on our existing NIEHS-funded R01, we will employ an innovative suite of imaging, genetic, and biochemical tools in combination with induced neurons (iNs) from male and female Alzheimer’s disease patients and unaffected individuals to answer longstanding questions about the mechanisms by which environmental toxicant exposures drive Alzheimer’s disease pathology. These studies will also provide the basis for a larger Alzheimer’s focused R01 grant to uncover how gene-environment interactions contribute to Alzheimer’s disease.

PI_NAMEs: FREYBERG, ZACHARY  (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: 3-Dimensional;abeta accumulation;Acceleration;Affect;Age;age related neurodegeneration;Age related pathologies;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;American;Amyloid beta-Protein;biochemical tools;Brain;Cells;Cessation of life;Cognitive;cognitive function;Cryo-electron tomography;cytotoxic;decrease resilience;Dementia;Development;Disease;Disease Progression;Environmental Exposure;environmental pesticide exposure;Environmental Risk Factor;Epigenetic Process;Etiology;Exhibits;Exposure to;familial Alzheimer disease;Female;Fibroblasts;Fostering;Functional disorder;Funding;gene environment interaction;Genetic;Glutamate Transporter;Grant;Human;hyperphosphorylated tau;Image;Impaired cognition;Impairment;In Situ;Incidence;Individual;Induced Neurons;innovation;Intervention;knock-down;Link;live cell imaging;Long-Term Potentiation;male;Measures;Mediating;Memory Loss;men;Messenger RNA;Metabolic;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Motor;National Institute of Environmental Health Sciences;Nerve Degeneration;neuron loss;Neuronal Plasticity;neuronal survival;Neurons;Neurotoxins;novel;novel strategies;novel therapeutics;overexpression;Oxidative Stress;Oxidative Stress Induction;Paraquat;Pathogenesis;Pathologic;Pathology;Patients;Persons;pesticide exposure;Pesticides;Play;Process;Production;progressive neurodegeneration;protein aggregation;Protein Biosynthesis;Reactive Oxygen Species;Reporter;resilience;Ribosomes;Role;Rotenone;Rough endoplasmic reticulum;Sex Differences;Site;Stress;Structure;Synapses;Synaptic plasticity;System;tau aggregation;tau Proteins;tool;Toxic Environmental Substances;Toxicant exposure;trafficking;transcriptomics;Translations;Vesicle;vesicular glutamate transporter 2;Woman;women patients;women versus men;Work

PROJECT_TITLE: Impact of pesticide exposure on mechanisms of neuroplasticity in Alzheimer's Disease

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE This proposal is relevant to public health because there is currently no available treatment for children with long- segment airway defects. Tissue engineering has the potential to replace diseased tissue with healthy, living tissue capable of repair and growth. A composite tracheal graft that possesses the mechanical properties needed to maintain graft patency and the biocompatibility to support regeneration will provide a viable solution for this complex population.

PI_NAMEs: CHIANG, TENDY  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Air Movements;airway epithelium;airway obstruction;Animal Model;Animals;Attenuated;Autologous;Autologous Transplantation;Biocompatible Materials;Biological;biomaterial compatibility;Biomechanics;Biopsy;Bronchi;Bronchoscopy;Cartilage;cartilaginous;Cells;Child;Childhood;Chondrocytes;Chondrogenesis;Clinical;Clinical Management;clinical translation;Complex;conditional knockout;Congenital Abnormality;Defect;Detection;Development;Diameter;Dimensions;Disease;efficacy testing;Epithelial Cells;Epithelium;epithelium regeneration;Expression Profiling;extracellular;Extracellular Matrix;Generations;Growth;Host Defense;Image;Implant;implantation;improved;Infection;Inflammation;Injury;innovation;Intervention;Legal patent;Liquid substance;Maintenance;Malignant Neoplasms;Maps;Mass Spectrum Analysis;mechanical properties;Mechanics;Mediating;Modeling;Modification;mouse model;Mucociliary Clearance;Mus;Natural regeneration;Operative Surgical Procedures;Organ;Oryctolagus cuniculus;Outcome;parent project;Patients;Performance;Population;preservation;Production;progenitor;protein expression;Public Health;Radial;radiological imaging;repaired;replacement tissue;respiratory surgery;restoration;Role;shear stress;sheep model;Source;Splint Device;stem;stress reduction;Surface;Techniques;Testing;Time;Tissue Engineering;Tissues;Trachea;Tracheal Diseases;translational barrier;Trauma;Work

PROJECT_TITLE: Tissue-engineered trachea composites for long-segment airway replacement (DIVERSITY SUPP - Hussein)

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Violence Research;Youth Violence

PHR: Narrative Population-level maltreatment prevention could significantly improve public health, but it is not yet clear how to prevent maltreatment at scale. The proposed project will estimate the potential for major social safety net policies (EITC, CTC, SSI, TANF, SNAP/WIC, and Medicaid/CHIP) to prevent neglect and physical abuse in young children. To accurately and comprehensively identify the policies with the greatest potential impact, the project will measure and account for the ways that policies interact with one another and examine effects on both maltreatment-related injuries and Child Protective Services reports.

PI_NAMEs: MASON, SUSAN M. (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: 18 year old;abuse neglect;Accident and Emergency department;Accounting;Address;Affect;Age;aged;Asian;Black race;Categories;Child;Child Abuse and Neglect;child protective service;Childhood Injury;Communities;Data;Databases;design;Disability status;Economics;Eligibility Determination;Equity;Ethnic Origin;evidence base;experience;Failure;Family;family structure;Financial Hardship;Goals;Health Care Costs;Hispanic;Hospitalization;Hybrids;improved;Individual;Information Systems;Injury;innovation;Inpatients;Knowledge;life span;Link;maltreatment;marginalization;Measures;Medicaid;Modeling;Near Drowning;neglect;Not Hispanic or Latino;Outcome;Parenting Education;Parents;physical abuse;Policies;Population;Poverty;poverty alleviation;prevent;Prevention;preventive intervention;programs;Psyche structure;Public Health;Race;Reporting;Research;Research Personnel;response;Risk;safety net;Shapes;social;Social Welfare;Social Well-Being;Special Supplemental Nutrition Program for Women, Infants, and Children;Stress;stressor;structural determinants;Subgroup;System;Time;Time trend;Visit

PROJECT_TITLE: Estimating Impacts of Social Safety Net Generosity on Neglect and Physical Abuse in Young Children

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Suicide;Suicide Prevention;Telehealth

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Emergency Departments (EDs) are increasingly providing the first line of clinical contact for adolescents with suicidal ideation and attempts, many of whom remain at high risk for recurrent crises following discharge. This proposal will lead to a novel text-based intervention supporting parents in engaging in recommended suicide prevention activities to promote post-discharge youth safety. Findings from this study will inform a scalable intervention approach intended to improve post-ED continuity of care and reduce youth suicidal behavior and related crises during a high-risk care transition.

PI_NAMEs: CZYZ, EWA KARINA (contact)

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;adaptive intervention;Address;Adolescent;Adoption;Affect;Age;arm;brief intervention;Caregivers;Caring;Child;Clinical;Continuity of Patient Care;coping;Data;design;Distress;effective intervention;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Elements;Emergency Care;Emergency department visit;Emergency Department-based Intervention;Emotions;experience;Family;Feeling;Feeling suicidal;follow-up;Funding;Future;Goals;Health system;high risk;high risk parents;Hour;Hybrids;implementation barriers;implementation evaluation;implementation facilitators;implementation framework;improved;Individual;Interruption;Intervention;Life;Measures;Mediating;Monitor;multi-site trial;National Institute of Mental Health;negative affect;novel;Outcome;parenting intervention;Parents;Patients;pediatric patients;Personal Satisfaction;Persons;Practice Guidelines;prevent;primary outcome;Randomized;randomized trial;Recommendation;Recurrence;Reporting;routine care;Safety;Sampling;secondary outcome;Self Care;Self Efficacy;Services;Stress;suicidal;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Surveys;Text;Text Messaging;text messaging intervention;texting support;therapy design;Time;treatment arm;uptake;Work;Youth

PROJECT_TITLE: Effectiveness of text-based support for parents of suicidal adolescents following emergency department visits

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Arthritis;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences;Osteoarthritis;Pain Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative The aim of this ancillary application is to collect additional data to investigate the interplay between chronic pain and mild-cognitive impairment. The findings will facilitate the development of new biomarkers and treatments for Alzheimer’s disease and its related dementias (AD/ADRD).

PI_NAMEs: KONG, JIAN  (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Acceleration;Administrative Supplement;alternative treatment;Alzheimer's Disease;Biological Markers;Blood specimen;Brain;chronic pain;Clinical Trials;Cognition;Cognitive;cognitive function;cohort;Data;Dementia;dementia risk;Development;Disease;Elderly;Functional disorder;Funding;Grant;Impaired cognition;Individual;inflammatory marker;Knee Osteoarthritis;locus ceruleus structure;Measurement;Mediating;Memory;mild cognitive impairment;mind/body;National Center for Complementary and Integrative Health;neuroinflammation;neuroregulation;noradrenergic;Pain Free;Parents;Participant;Patients;Persons;Play;Population;Research;Role;Sample Size;Structure;System;U-Series Cooperative Agreements;United States National Institutes of Health

PROJECT_TITLE: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Biotechnology;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Muscular Dystrophy;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: San Diego

ORG_NAME: MYOGENE BIO, LLC

PHR: Project Narrative In this project, the long-term durability of a gene editing therapy for Duchenne muscular dystrophy will be assessed in a humanized mouse model. The potential for long-lasting effect will be determined by comparing functional and molecular efficacy at 6 months versus 2 months. The proposed work will contribute towards development of an innovative gene editing therapy for the treatment of 50% of Duchenne muscular dystrophy patients.

PI_NAMEs: YOUNG, COURTNEY S (contact)

PROGRAM_OFFICER_NAME: PITTENGER, STEVEN THEODORE

PROJECT_TERMS: Acceleration;Advanced Development;Affect;Aftercare;aged;Alleles;Becker Muscular Dystrophy;Carrying Capacities;Cells;Cessation of life;Clinical;clinical development;Code;cohort;Complex;CRISPR/Cas technology;Data;design;Development;Disease;DNA;Dose;drug development;Duchenne muscular dystrophy;Dystrophin;efficacy outcomes;efficacy study;Environment;exon skipping;Exons;experience;Future;gene product;gene replacement;gene replacement therapy;gene-editing approach;Genes;Genetic;genotyped patients;Glycoproteins;Grant;Histology;Human;humanized mouse;Immune response;Immunosuppression;improved;in vivo;Injections;innovation;Learning;Life;mdx mouse;meetings;micro-dystrophin;Molecular;molecular marker;mouse model;Mus;Muscle;muscle degeneration;Muscle function;Muscular Atrophy;Mutation;next generation;non-Native;Orphan Drugs;Patients;postmitotic;preclinical efficacy;preclinical study;premature;preservation;Proteins;Rare Diseases;Reading Frames;Recommendation;Regimen;Regulation;restoration;Risk Reduction;Symptoms;Testing;therapeutic genome editing;Tissues;Transgenes;United States;vector;Voice;Wasting Syndrome;Work

PROJECT_TITLE: Durability of a gene editing therapy that restores dystrophin in a humanized mouse model of Duchenne muscular dystrophy


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Congenital Structural Anomalies;Digestive Diseases;Liver Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_CITY: MILWAUKEE

ORG_DEPT: PEDIATRICS

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Biliary atresia is a neonatal inflammatory, sclerosing lesion of the bile ducts that results in cirrhosis. This proposal will determine the mechanism of neutrophil extracellular trap formation (NETosis) in biliary atresia and the role of NETosis in promoting fibrosis. Knowledge gained could result in the identification of novel therapeutics targeting NETosis, thus preventing cirrhosis in children with biliary atresia.

PI_NAMEs: DWINELL, MICHAEL B;MACK, CARA LYNN (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Address;bile duct;Biliary;Biliary Atresia;Biliary cirrhosis;biliary tract;Biological Markers;Biology;Cell Line;Chemotactic Factors;Child;Childhood;cholangiocyte;Chronic;Cirrhosis;Data;Disease;Electrons;extracellular;Fibroblasts;fibrogenesis;Fibrosis;Hepatic;Hepatic Stellate Cell;Human;IL17 gene;IL8 gene;IL8RB gene;Immune;Immunophenotyping;infancy;Inflammatory;Injury;Knowledge;Lesion;Literature;Liver diseases;liver transplantation;Mediating;Mitochondria;mouse model;Mus;Myofibroblast;NADPH Oxidase;Neonatal;neutrophil;new therapeutic target;novel;novel therapeutics;Organ;Organoids;Outcome;Pathogenesis;Pathway interactions;Patients;peripheral blood;Plasma;prevent;Production;Proteins;Reactive Oxygen Species;Research;Role;Rotavirus;Signal Transduction;Source;stellate cell;Testing;Thromboplastin;transcriptomics

PROJECT_TITLE: Mechanisms of neutrophil extracellular trap formation and contribution to biliary fibrosis in biliary atresia

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ORG_CITY: Aurora

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE Candida albicans is a commensal fungus that colonizes the intestine of most healthy people but has the capacity to cause infections and exacerbate inflammation in susceptible people. Immune status determines risk for C. albicans-associated disease, but the impact of immune environment on C. albicans inherent pathogenic potential is not well understood. This proposal aims to comprehensively define the impact both homeostatic and pathogenic immune environments on C. albicans pathogenic potential.

PI_NAMEs: OST, KYLA  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Adherence;Antibodies;Biology;Candida albicans;Cells;Colitis;Disease;Environment;Foundations;fungus;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic Transcription;Goals;gut colonization;gut microbiome;Human;Hyphae;Immune;immunodeficiency;Immunoglobulin A;immunological status;in vivo;Individual;Infection;Inflammation;Inflammatory;Intestines;Invaded;Investigation;Life;Life Style;Link;Microbe;microbial;microbial community;microbiome;Modeling;Morphology;mouse model;murine colitis;Mus;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Phenotype;Predisposition;prevent;Regulation;Risk;Role;Study models;targeted treatment

PROJECT_TITLE: Dissecting the impact of immune environment on Candida albicans pathogenic potential in the gut


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Immunotherapy;Orphan Drug;Patient Safety;Prevention;Rare Diseases;Regenerative Medicine;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The mission of this grant is to form a network of established blood and marrow transplant centers, such as the Stanford BMT-CT Program, that will collaborate and conduct impactful multicenter clinical trials investigating leukemia, lymphoma, and myeloma, as well as non-malignant diseases such as sickle cell anemia and aplastic anemia. The Division of BMT-CT at Stanford has been an outstanding contributor to past CTN clinical trials with 579 patients enrolled on 25 clinical trials and has been an active participant in CTN committees and related activities. The trial proposed in the current application aims to identify a safe and novel GVHD prevention strategy in patients lacking HLA matched donors, and if successful, will address a main complication that limits safe allogeneic transplantation and is a major source of morbidity and mortality following allogeneic HCT for patients with ALL, AML, or MDS.

PI_NAMEs: MUFFLY, LORI  (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Acute Graft Versus Host Disease;Adult;Adverse event;Advisory Committees;Allogeneic Bone Marrow Transplantation;Allogenic;Allografting;Aplastic Anemia;Area;Autologous Transplantation;Basic Science;bench-to-bedside translation;Blood;Bone Marrow Transplantation;CD3 Antigens;Cell Therapy;Cells;chimeric antigen receptor T cells;CLIA certified;Clinical;clinical center;Clinical Research;clinical trial protocol;Clinical Trials;Clinical Trials Network;Collaborations;Complication;conditioning;Cyclic GMP;Data;Data Aggregation;data management;design;Development;Disease;disorder risk;Distress;Engineering;Enrollment;experience;Faculty;Financial Hardship;financial toxicity;Funding;Future;genetically modified cells;Goals;graft failure;graft vs host disease;Grant;Health Services;Hematological Disease;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Homologous Transplantation;Immunotherapy;improved;Incidence;Infrastructure;innovation;Institution;Institutional Review Boards;International;Intervention;Interview;investigator-initiated trial;Laboratories;Leadership;leukemia;Lymphoma;Mission;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Multiple Myeloma;Non-Malignant;novel;novel strategies;operation;Outcome;Participant;participant enrollment;Patient Participation;Patients;Phase;Phase I/II Clinical Trial;Phase Ib/II Trial;Play;Population;pre-clinical;prevent;Prevention strategy;primary outcome;Procedures;Program Research Project Grants;programs;Prophylactic treatment;protocol development;Protocols documentation;Randomized, Controlled Trials;Recurrent disease;Regulatory T-Lymphocyte;Reporting;Research;Research Activity;Research Personnel;Research Support;Residual Neoplasm;Risk Reduction;Role;Safety;Sickle Cell Anemia;Site;social health determinants;Source;stem;study population;T-Lymphocyte;Tacrolimus;Target Populations;Testing;Toxic effect;translational clinical trial;Translational Research;transplant centers;Transplant Recipients;Transplantation;transplantation therapy;treatment planning;trial planning;Umbilical Cord Blood;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: BMT Core - Stanford University


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Social Determinants of Health

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative This is an application requesting for an Administrative Supplement to Enhance Diversity for the NIH U01 HL160274 grant. The proposed combined clinical and bioinformatics studies, although within the scope of the parent grant, are not in the funded Specific Aims. Our proposed study promises to contribute both technically and conceptually to the overall understanding of the molecular mechanisms underlying HFpEF patients in underserved communities.

PI_NAMEs: CADEIRAS, MARTIN ;CHIAMVIMONVAT, NIPAVAN  (contact);LOPEZ, JAVIER ENRIQUE

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Administrative Supplement;Bioinformatics;Blood specimen;California;career;career development;Clinical;Clinical Data;cohort;comorbidity;Complement;EFRAC;experience;Fostering;Funding;Goals;Grant;Health;Heart failure;improved;Individual;individualized medicine;insight;Link;Mentors;Molecular;multi-ethnic;Multiomic Data;Outcome;parent grant;parent project;Patients;Phenotype;Physicians;Population;preservation;prospective;Request for Applications;Research;Risk;Risk Factors;Scientist;Services;social health determinants;sociodemographic factors;Testing;Training;underserved community;United States National Institutes of Health

PROJECT_TITLE: A prospective multiethnic HFpEF cohort from California's Central Valley