NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Disability Research;Pain Research;Pediatric

PHR: PROJECT NARRATIVE - RELEVANCE Gastroparesis and functional dyspepsia affect both children and adults, is responsible for great morbidity, and is associated with increased mortality. Little is understood regarding the epidemiology, causes, and natural history of these disorders in adults but the knowledge void is even greater in children. The results of this proposal will provide novel insights into their clinical expression and course in children.

PI_NAMEs: CHUMPITAZI, BRUNO PEDRO;PREIDIS, GEOFFREY A (contact)

PROJECT_TERMS: Adolescent;Adult;Affect;age difference;age group;age related;Anxiety;Assessment tool;Caring;Categories;Child;Childhood;children's depression inventory;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;cohort;common symptom;comorbidity;cost;Data;Development;Diabetes Mellitus;dietary;Dietitian;disability;Disease;Distress;Duodenum;Dyspepsia;early satiety;Eating Behavior;eosinophil;Epidemiology;Epigastrium;Equipment and supply inventories;Etiology;field study;Food;functional disability;Functional disorder;Functional Gastrointestinal Disorders;Future;Gastric Emptying;Gastritis;gastrointestinal;Gastroparesis;General Population;Goals;Hospitalization;Hypersensitivity;improved;Incidence;innovation;insight;interdisciplinary approach;Intestinal permeability;Knowledge;Link;mast cell;Measures;Mechanics;Mental Depression;Methodology;Methods;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Nausea and Vomiting;neuropathology;novel;Obstruction;Operative Surgical Procedures;Outcome Assessment;Pain;pain catastrophizing;Parents;Patients;pediatric patients;Population;Prevalence;prospective;Psychologist;psychosocial;Quality of life;Questionnaires;Radionuclide Imaging;recruit;Registries;Research;Role;Sample Size;Satiation;Severities;Severity of illness;Site;Stomach;Symptoms;Testing;Toddler;trait;transition to adulthood;Treatment outcome;Validation;Visceral;Vomiting;Water;Work

PROJECT_TITLE: Advancing Clinical Science in Pediatric Gastroparesis


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Microbiome

ORG_CITY: EL PASO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO

ORG_STATE: TX

PHR: Project Narrative Gastroparesis affects approximately 10% of the US population, with patients suffering with chronic, severe and difficult to control symptoms of nausea, vomiting, inability to finish normal size meal, fullness and abdominal pain. The NIH GpCRC has generated an extensive number of individual studies, which have increased our knowledge and concepts of understanding of this condition, its complications, diagnostic challenges and clinical outcomes. As the next step in the continuation of our research, we are proposing two new clinical projects: 1- Investigate whether the composition of the gut microbiota, in the stomach and duodenum of GP patients differs in idiopathic, compared to diabetic etiologies and control patients; and 2- investigate how a new medication, utilizing the mechanism of 5 Hydroxytryptamine (5HT) stimulation by a selective 5HT4 receptor agonist, which is already FDA approved for constipation, may help to reduce symptoms of gastroparesis as well as accelerate gastric emptying while having a satisfactory profile adverse event.

PI_NAMEs: MCCALLUM, RICHARD WARWICK (contact);SAROSIEK, IRENE

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Abdominal Pain;Acceleration;Adverse event;Adverse reactions;Affect;Agonist;Antral;Biopsy;Buspirone;capsule;Chronic;Clinical;clinical care;Clinical Research;Clinical Trials;clinically relevant;cohort;Constipation;Control Groups;design;diabetic;diabetic gastroparesis;Diagnosis;Diagnostic;Diagnostic tests;diagnostic value;Dissection;Double-Blind Method;Duodenum;dysbiosis;efficacy evaluation;Endoscopy;Enrollment;Etiology;Exhibits;FDA approved;Functional disorder;Gastric Emptying;gastric microbiota;Gastroparesis;Grant;gut microbiota;Immunologics;improved;Individual;insight;Investigation;Knowledge;Large Intestine;laxative;Medical;meetings;Methodology;Methods;microbiota;microbiota composition;Motility;Mucous Membrane;National Institute of Diabetes and Digestive and Kidney Diseases;Nausea;Operative Surgical Procedures;Outcome;Pathogenesis;Pathologic;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacologic;Placebo Control;Placebos;Population;Protocols documentation;Pyloric sphincter structure;Qualifying;Radionuclide Imaging;Randomized;randomized placebo controlled trial;Reaction;receptor;Recommendation;reduce symptoms;Registries;Research;Research Design;response;Role;Safety;Sampling;Serotonin;Serotonin Receptors 5-HT4;Severities;Small Intestines;Smooth Muscle;Stomach;Subgroup;Submucosa;symptomatic improvement;Symptoms;Testing;Time;Tissue Sample;Tissues;treatment duration;Treatment Efficacy;United States National Institutes of Health;Upper digestive tract structure;Vomiting;wireless

PROJECT_TITLE: A multicenter, double-blind, randomized, placebo- controlled, parallel study to assess the efficacy of 5- HT4 agonist prucalopride for the treatment of diabetic and idiopathic gastroparesis


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Cardiovascular;Diabetes;Genetics;Wound Healing and Care

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Clinical trials on VEGF therapy to rescue diabetic vasculopathy has produced limited to no benefits. Troubleshooting VEGF therapy in a way that would help maximize clinical outcomes would fill a major void in the current healthcare needs. The proposed research will unveil the critical role of PLCγ2 in VEGF signaling to help improve the efficiency and robustness of vasculogenic VEGF therapy in wound healing in diabetic subjects.

PI_NAMEs: SINGH, KANHAIYA  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Accounting;Address;Adjuvant;Adult;Affect;aging population;Angioblast;angiogenesis;beneficiary;blood vessel development;Blood Vessels;cadherin 5;Cadherins;Cardiovascular system;CDH5 gene;Cell Compartmentation;Cells;chronic wound;Clinical;Clinical Research;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;combination gene therapy;Complex;cost;CpG Islands;Cyclic AMP-Dependent Protein Kinases;demethylation;Dermal;Development;Diabetes Mellitus;diabetic;diabetic ulcer;diabetic wound healing;Diglycerides;Dinoprostone;DNA;DNA Methylation;Down-Regulation;Eicosanoids;Elements;Endothelial Cells;Endothelium;Environment;Epigenetic Process;epigenetic silencing;Exhibits;expectation;falls;functional outcomes;Gene Combinations;Gene Expression;Gene Targeting;Generations;Genes;Granulation Tissue;Guide RNA;Healthcare;Human;Hyperglycemia;Hypermethylation;improved;in vivo;Infection;injured;Injury;Inositol;Ischemia;Knockout Mice;lipid mediator;Literature;lymphatic vessel;Macrophage;Mediating;Medicare;Methylation;Molecular;Mus;Myelogenous;Myeloid Cells;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;Outcome Study;Pathway interactions;Patients;Perfusion;Phosphatidic Acid;PIK3CG gene;PLCgamma2;Population;Prevalence;prevent;Process;Production;promoter;Protein Dephosphorylation;Proto-Oncogene Proteins c-akt;public health relevance;Reactive Oxygen Species;Recovery of Function;Regimen;Regulation;Reporting;Research;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;Testing;Therapeutic;Therapeutic Intervention;therapy outcome;Tissues;tool;TREM2 gene;tripolyphosphate;Vascular Diseases;Vascular Endothelial Growth Factors;Vascularization;vasculogenesis;Vasculogenic;Work;wound;wound healing;wound vascularization

PROJECT_TITLE: Regulatory Mechanisms Addressing Diabetic Vasculopathy

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed study will refine and evaluate components of a school-based multi-level communications strategy that addresses intrapersonal, interpersonal, and institutional factors associated with HPV vaccination uptake and completion. Participatory methods and community engagement are foundational to the approach. Achieving the goals of this project has the potential to inform the South African Integrated School Health Programme regarding effective strategies to promote uptake and completion of HPV vaccine amongst girls and boys and provide an approach that is replicable in other low- and middle-income settings where the burden of HPV-associated cancers is high.

PI_NAMEs: BUTLER, LISA MICHELLE;KATZ, INGRID T. (contact)

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: acceptability and feasibility;Address;Administrator;Adolescent;Age;Anogenital cancer;Area;boys;Cancer Control;Cancer Etiology;cancer prevention;Caring;Charge;Child;civil society;Clinical Trials;Communication;Communities;community engagement;Consult;COVID-19;Decision Making;design;Dose;Drops;Educational Curriculum;Effectiveness;effectiveness evaluation;elementary school;Eligibility Determination;Enrollment;Ensure;Epidemic;Evaluation;Exposure to;feasibility trial;Female;fifth grade;Focus Groups;Gender;girls;Goals;Government;Grant;Health;Health behavior;health communication;health equity;Healthcare;HIV;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human Resources;hybrid type 2 trial;Hybrids;Immunization;Immunization Programs;improved;Income;Individual;Influentials;Institution;Interruption;Intervention;Interview;learning materials;Link;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant oropharynx neoplasm;Measures;Medical;Methods;Misinformation;Nurses;Ownership;Parents;Participant;Phase;Population Heterogeneity;Preparation;Prevention;programs;Questionnaires;Randomized;Randomized, Controlled Trials;recruit;Research;Research Personnel;Resource-limited setting;Sampling;school health;School-Age Population;Schools;sexual debut;Sexually Transmitted Diseases;social media;South Africa;South African;Structure;Students;study population;System;teacher;Testing;trial planning;United States;uptake;urban setting;Vaccinated;vaccination strategy;vaccine hesitancy;Vaccines;Voice;Vulnerable Populations;Women's mortality;working group;young woman

PROJECT_TITLE: Multi-level school-based intervention to improve HPV vaccine uptake and completion in South Africa


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: PROJECT NARRATIVE Family planning clinics are a primary source of health care access for women, providing an ideal opportunity to integrate HIV prevention efforts (e.g., pre-exposure prophylaxis (PrEP) information and care) into existing clinic practices. Through preliminary work, we have identified successful strategies to increase PrEP uptake among Black cisgender women. Using a stepped-wedge hybrid trial, we will implement these strategies within the Planned Parenthood of Illinois health center setting to improve PrEP care continuum outcomes among this population with the goal of reducing new HIV infections among women and contributing to efforts to End the Epidemic.

PI_NAMEs: HAIDER, SADIA  (contact);JOHNSON, AMY KRISTEN

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Address;Administrator;Adopted;Adoption;AIDS prevention;Area;Black Populations;Black race;black women;Caring;Chicago;cis-female;cisgender;Clinic;Clinical;Continuity of Patient Care;Data;Disparity;Education;effective intervention;Effectiveness;effectiveness evaluation;effectiveness trial;Electronic Health Record;Eligibility Determination;Environment;Epidemic;experience;Family Planning;Federally Qualified Health Center;Goals;Health;health care availability;Health Services Accessibility;Health system;High Prevalence;High Risk Woman;HIV;HIV Infections;Hybrids;Illinois;implementation efforts;implementation evaluation;implementation intervention;implementation outcomes;implementation science;implementation strategy;improved;Incidence;Inequity;Infection;Injections;insight;Intervention;Interview;Knowledge;Lesbian Gay Bisexual Transgender Queer;Maintenance;men who have sex with men;Methods;Neighborhood Health Center;Outcome;patient population;Patients;Pharmaceutical Preparations;Planned Parenthood Federation of America;Population;pre-exposure prophylaxis;prevent;Prevention strategy;Primary Care;Provider;Race;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research Methodology;Risk;satisfaction;scale up;Services;sex;sexually active;Site;social determinants;Source;Standardization;structural health determinants;Time;tool;Training;transgender women;uptake;Woman;Work

PROJECT_TITLE: Implementation of PrEP Care Among Women in Family Planning Clinics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-W(50)R]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Estrogen;Liver Disease;Nutrition;Obesity;Women's Health Research

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: The overall goal of this proposal is to determine the collective contributions of glucagon, insulin, estrogen, and altered gluconeogenesis substrate availability to the metabolic dysfunction of patients with T2DM. The strong focus on glycerol metabolism is justified based on preliminary data and may highlight an important and previously underappreciated therapeutic target for patients with T2DM.

PI_NAMEs: HE, LING ;WONDISFORD, FREDRIC E. (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Address;Affect;alpha-glycerophosphoric acid;Carbon;Data;Diabetes Mellitus;Enzymes;EP300 gene;Esterified Fatty Acids;Estradiol;Estrogen Receptors;Estrogens;Fasting;fatty acid metabolism;Fatty Acids;Fatty Liver;Female;Gene Expression;Genes;Genetic Transcription;Glucagon;Gluconeogenesis;Glucose;glucose metabolism;glucose production;Glycerol;Glycerol Kinase;Goals;Hepatic;hepatic gluconeogenesis;Hepatocyte;Hyperglycemia;Hyperinsulinism;in vivo;Infusion procedures;insight;Insulin;Insulin Receptor;Insulin Resistance;insulin sensitivity;Knockout Mice;Label;Laboratories;Link;lipid biosynthesis;lipid metabolism;Lipids;Liver;Low Prevalence;male;Measurement;Mediator;men;Metabolic dysfunction;Metabolic Pathway;Metabolism;metabolomics;Modeling;mouse model;Mus;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Nutritional;Obesity;Ovariectomy;oxidation;Pathway interactions;Patients;Positioning Attribute;Prediabetes syndrome;Premenopause;Pyruvate;Receptor Signaling;Regulation;Role;sex;Sex Differences;Signal Transduction;Technology;Testing;therapeutic target;Transcription Coactivator;Transcriptional Regulation;Triglycerides;Universities;Woman;Women's prevalence

PROJECT_TITLE: Glycerol Regulation of Gluconeogenesis and Fatty Acid Metabolism

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Genetics;Mental Health;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE We recently discovered a new type of intercellular communication pathway: Arc, a gene critical for memory and long-lasting forms of synaptic plasticity, forms virus-like capsids that transport proteins and RNA cell-to-cell. The goal of this proposal is to investigate the mechanisms of Arc intercellular signaling and synaptic plasticity. Arc dysregulation is implicated in neurodevelopmental and psychiatric disorders; thus, our work will help determine mechanisms of cognition and memory.

PI_NAMEs: SHEPHERD, JASON D (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Acute;Amino Acids;AMPA Receptors;Binding;Biochemical;Biogenesis;Brain;Capsid;Carrier Proteins;Cell Communication;Cells;Chromatin;Cognition;Data;Dendrites;Dependence;Disease;Electrophysiology (science);Encapsulated;Endocytosis;Epigenetic Process;Excision;experience;experimental study;extracellular vesicles;Family;Funding;gag Gene Products;Genes;Glutamate Receptor;Goals;Hippocampus;Homeostasis;Image;imaging approach;in vivo;Incubated;insight;Intellectual functioning disability;intercellular communication;Knock-out;Knockout Mice;Label;Learning;Long-Term Depression;Long-Term Potentiation;loss of function;LoxP-flanked allele;luminescence;Maintenance;Measures;Mediating;Mediator;Memory;memory consolidation;Mental Depression;Mental disorders;Messenger RNA;Modeling;Molecular;Mus;mutant;nanoluciferase;Neurodevelopmental Disorder;Neurons;novel;Nucleic Acid Regulatory Sequences;patch clamp;Pathway interactions;Physiological;Plasmids;Play;Process;Promoter Regions;Property;protein expression;Proteins;receptor;receptor expression;Regulation;Retrotransposon;Retroviridae;RNA;Role;self assembly;Signal Transduction;Slice;Structure;Surface;Synapses;Synaptic plasticity;System;Techniques;Tertiary Protein Structure;Testing;trafficking;Transfection;Transfer RNA;Transgenic Mice;uptake;vesicular release;Viral;Virus;Work

PROJECT_TITLE: Investigating the mechanisms of Arc-dependent synaptic plasticity

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Microbiome;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: DALLAS

ORG_DEPT: PEDIATRICS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: 1 Feeding intolerance develops in 75% of very low birth weight preterm infants leading to malnutrition and poor 2 neurodevelopmental outcomes. Non-specific signs of developmental feeding intolerance (DFI) are often 3 incorrectly interpreted as pathologic feeding intolerance (PFI); as a result, frequent feeding delays and 4 interruptions lead to prolonged use of parenteral (intravenous) nutrition and central catheters, increasing 5 morbidity in infants who do not have gastrointestinal pathology. This proposal seeks to provide evidence for 6 objective biomarkers to differentiate DFI from PFI with the goal of limiting unnecessary feeding delays, parenteral 7 nutrition, and improving outcomes.

PI_NAMEs: ORTIGOZA, ERIC BRUM (contact)

PROGRAM_OFFICER_NAME: SANTOS SCHMIDT, AUGUSTO FREDERICO

PROJECT_TERMS: 16S ribosomal RNA sequencing;Abdomen;Address;Age;age difference;Area;Bioinformatics;Biological Markers;biomarker development;biomarker validation;Blinded;career development;Catheters;Child Health;Clinical;Clinical Research;Collection;commensal bacteria;commensal microbes;Complex;Computer Models;Cutaneous;Data;Dedications;Development;Development Plans;Enteral Feeding;Environment;evidence base;Feces;feeding;Fostering;Foundations;Funding;gastrointestinal;Gastrointestinal Motility;Gastrointestinal Physiology;Goals;Growth;gut microbiome;gut microbiota;Health;high throughput analysis;Hospitals;Ileus;improved outcome;Infant;innovation;Interruption;Intestinal Obstruction;Intravenous;K-Series Research Career Programs;Knowledge;Lead;Leadership;Learning;Length of Stay;Longitudinal cohort study;Machine Learning;Malnutrition;Master of Science;Measurement;Measures;Medical center;Mentors;Mesentery;metabolomics;Methods;microbiome;microbiota;microbiota metabolites;Monitor;Morbidity - disease rate;Motility;motility disorder;Multicenter Studies;multidisciplinary;Near-Infrared Spectroscopy;Necrotizing Enterocolitis;Neonatal;Neonatal Intensive Care;Neonatal Intensive Care Units;novel;nutrition;operation;Outcome;Parenteral Nutrition;Pathologic;Pathology;patient population;perinatal medicine;Physicians;Physiological;predictive modeling;Pregnancy;Premature Infant;prevent;Principal Component Analysis;Productivity;programs;prospective;Prospective, cohort study;Proteobacteria;recruit;Research;Research Personnel;Risk;Sample Size;segregation;Shotguns;Signal Transduction;skills;skills training;Spontaneous intestinal perforation;Stomach;stool sample;System;Taxonomy;Testing;Time;tool;Training;translational medicine;Validation;Very Low Birth Weight Infant;Volatile Fatty Acids;Work

PROJECT_TITLE: Integrating Novel Physiological Biomarkers of Feeding Intolerance in Preterm Infants

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Contraception/Reproduction;Gene Therapy;Genetics;Maternal Health;Maternal Morbidity and Mortality;Nanotechnology;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative The proposed research is relevant to public health because the development of placental therapies would lead to a potential treatment for Placental Insufficiency, Fetal Growth Restriction and a reduced risk of developing adult diseases such as diabetes and cardiovascular disease. Furthermore, this delivery mechanism may aid with developing both placental-specific therapies in other placental pathologies such as Pre-eclampsia and other organ-specific therapeutics as well as novel disease models in nonhuman primates. The proposed studies are highly innovative and exploratory and will assess the utility and feasibility of our approach while building successful collaboratively developed research tools.

PI_NAMEs: JONES, HELEN N (contact);SCHMIDT, JENNA ANN

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Address;Admission activity;Adult;Adverse effects;adverse pregnancy outcome;Animal Model;Animals;Aromatase;Arteries;Basic Science;Biology;Blood Vessels;Cardiovascular Diseases;Catheters;Chemistry;Child;Clinical Research;Development;Diabetes Mellitus;Disease;disease model;Environment;experience;fetal;Fetal Growth;Fetal Growth Retardation;Fetal health;Fetus;Florida;Functional disorder;gene therapy;Genetic;Giant Cells;Goals;guinea pig model;Health;Heart;Human;improved;in utero;in vivo;Injections;innovation;Insulin-Like Growth Factor I;interest;Intervention Studies;Knowledge;Lead;Life;life span;Macaca mulatta;Maternal complication;Maternal Health;Maternal Physiology;Maternal-Fetal Exchange;Mediating;Metabolic;Metabolism;Methods;model development;Modeling;Molecular;Morbidity - disease rate;mortality;Mothers;mouse model;multidisciplinary;nanocarrier;nanoparticle;nonhuman primate;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Obesity;offspring;Operative Surgical Procedures;Organ;organ growth;Outcome;Pathology;pediatric pharmacology;Peptides;peptidomimetics;Peripheral;Personal Satisfaction;Physiological;Physiology;Placenta;Placental Biology;Placental Insufficiency;Placentation;Plasmids;Polymers;Positioning Attribute;post pregnancy;postnatal;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy Outcome;pregnant;Pregnant Women;premature;Premature Birth;prenatal stress;Prevention;promoter;Proteins;Public Health;Regulation;Reporter;Research;Research Personnel;Rest;Risk;Risk Factors;Safety;safety and feasibility;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic protein;Therapeutic Studies;tool;transgene expression;Translating;Translational Research;Treatment Efficacy;treatment strategy;Universities;Uterus;Wisconsin;Women's Health;Work

PROJECT_TITLE: Efficacy and safety of nanoparticle mediated placental gene therapy in nonhuman primates


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

ORG_STATE: MD

PHR: PROJECT NARRATIVE The difficulty of eliminating infected cells is a major impediment to eradicating HIV-1. The goal of this proposal is to develop therapeutic antibodies (tAbs) that target highly conserved CD4-induced (CD4i) Env epitopes and eliminate HIV-1 infected cells by antibody-dependent cellular cytotoxicity (ADCC). This novel class of tAb could be effective in reducing the size of the viral reservoir in people living with HIV-1.

PI_NAMEs: FINZI, ANDRES ;PAZGIER, MARZENA ELZBIETA (contact)

PROGRAM_OFFICER_NAME: ZHOU, YAN

PROJECT_TERMS: Antibodies;antibody engineering;Antibody Therapy;antibody-dependent cell cytotoxicity;Antibody-Dependent Enhancement;Antigen Receptors;antiretroviral therapy;Binding Sites;cancer therapy;CD4 Antigens;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Data;design;Development;DNA;Early treatment;Engineering;Engraftment;Epitope Mapping;Epitopes;Evaluation;Family;Fc Receptor;flexibility;Generations;Glycoproteins;Goals;HIV;HIV Envelope Protein gp120;HIV-1;humanized mouse;Hybrids;Immunodominant Epitopes;In Vitro;in vivo;Individual;Infection;Knowledge;Lead;Length;Link;Mediating;mimetics;Mus;Natural Killer Cells;neutralizing antibody;next generation;novel;particle;Peripheral Blood Mononuclear Cell;Persons;Plasma;Population;prevent;receptor binding;Research;Site;small molecule;Specificity;Structure;success;Surface;synergism;System;Testing;Therapeutic antibodies;tool;Transfer RNA;unnatural amino acids;Variant;Viral;viral rebound;Viral reservoir;Virion;Virus;weapons

PROJECT_TITLE: A new strategy to eliminate HIV-1-infected cells by unlocking the Env trimer

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BALTIMORE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Exposure of cells to chemical or environmental perturbations such as ultraviolet (UV) radiation and reactive oxygen species causes transcriptome-wide RNA damage, resulting in ribosomal collisions, and activation of ribotoxic stress response pathways. This proposal will characterize molecular mechanisms of how two kinases, ZAK and GCN2, are activated on collided ribosomes, and regulate the activation of the Ribotoxic Stress Response and Integrated Stress Response pathways that determine cellular life-or-death decisions during translational distress. These studies are likely to have broad therapeutic implications in understanding the anti-tumorigenic role of ribotoxic stress response in damaged skin cells which prevent their transformation into malignant carcinomas.

PI_NAMEs: SINHA, NILADRI K (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: analog;Apoptosis;Atlases;Biochemical;biological adaptation to stress;Biological Assay;Carcinoma;Cell Cycle Arrest;Cell Line;Cell Survival;Cells;cellular imaging;Cessation of life;Chemicals;Code;cofactor;Collaborations;coping;Cues;Data;Defect;Distress;Engineering;Equilibrium;Event;experimental study;Feedback;FRAP1 gene;gain of function;Gene Expression;Genetic;genetic manipulation;Goals;Growth and Development function;Homeostasis;imaging approach;in vivo;insight;JNK-activating protein kinase;kinase inhibitor;Laboratories;Life;live cell imaging;loss of function;Malignant - descriptor;MAP Kinase Kinase Kinase;MAPK8 gene;Measurement;Measures;Mediating;Memorial Sloan-Kettering Cancer Center;Mentors;Messenger RNA;Modeling;Molecular;Monitor;Mutagens;Mutation;novel;Outcome;p38 Mitogen Activated Protein Kinase;Pathway interactions;phosphoproteomics;Phosphotransferases;Positioning Attribute;prevent;programs;Proteomics;Reactive Oxygen Species;Reporter;Research;Resolution;response;Ribosomes;RNA;Role;Signal Pathway;Signal Transduction;Site;skills;skin damage;Specificity;Stress;Stress Response Signaling;Technology;tenure track;Testing;Therapeutic;Time;Training;transcriptome;Translating;tumorigenic;Ultraviolet Rays;Variant

PROJECT_TITLE: Molecular mechanisms of ZAK- and GCN2-mediated signaling in response to ribotoxic stress


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: FORT COLLINS

ORG_DEPT: CHEMISTRY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative. This project aims to develop new chemical tools that enable biologically active molecules to be constructed in a highly expedient fashion. In particular, coupling reactions that form carbon-carbon and carbon-heteroatom bond to pyridines are targeted. Two approaches, via phosphonium ion intermediates and by direct addition of nucleophiles, will deliver a set of reactions that are immediately applicable in drug discovery.

PI_NAMEs: MCNALLY, ANDREW  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: New Chemical Process to Selectively Functionalize Pyridines, Diazines and Pharmaceuticals

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Physical Activity;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Women living with HIV (WLWH) experience psychological, social and structural barriers to HIV care that result in outcome disparities compared to men. To address common co-occurring barriers (substance use, violence/trauma) for WLWH, we will implement a combination intervention of acceptance and commitment therapy, exercise and social support delivered by peer navigators among four different community-based organizations across the U.S. Combining interventions may enhance healthcare access and training peer navigators increases education access and may contribute to improved economic stability directly addressing social disparities of health.

PI_NAMEs: KARRIS, MAILE ANN YOUNG (contact)

PROJECT_TERMS: Abstinence;Accelerometer;Acquired Immunodeficiency Syndrome;Address;Adherence;antiretroviral therapy;Anxiety;barrier to care;behavior change;Behavior Therapy;Caring;Collection;Communities;community organizations;coping mechanism;Diagnostic;Diagnostic Factor;Economics;Education;education access;Effectiveness;effectiveness evaluation;effectiveness research;efficacious intervention;empowerment;Epidemic;Evaluation;Exclusion;Exercise;Exercise Therapy;experience;Exploration, Preparation, Implementation, and Sustainment;Feedback;flexibility;Focus Groups;Gender;girls;Goals;Health;health care availability;health disparity;Health Services Accessibility;HIV;HIV/AIDS;hybrid type 1 study;Hybrids;implementation framework;implementation process;implementation strategy;improved;Individual;Intervention;intervention effect;Interview;Loneliness;Maintenance;Measures;Mediator;Meditation;men;Mental Depression;Methods;mindfulness;Modification;Moods;Neighborhoods;Outcome;outcome disparities;Participant;peer;peer support;Periodicals;Persons;Pharmaceutical Preparations;Phase;Preparation;Process;Provider;psychologic;racism;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reduce health disparities;Reporting;Research;resilience;Resources;Risk;Self Efficacy;Site;social;social disparities;social stigma;Social support;standard of care;substance use;substance use treatment;sustainability framework;syndemic;therapy adherence;Time;Training;Trauma;trauma symptom;Violence;violence against women;Viral;Visit;Withdrawal;Woman;women of color;women's morbidity;women's outcomes

PROJECT_TITLE: Women focused Encounters for Resilience, Independence, Strength and Eudaimonia (WE RISE)


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Nutrition;Obesity;Physical Activity;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Low wage workers comprise one third of all workers in the U.S. and have a high prevalence of cardiometabolic risk factors, including depression and physical inactivity. The proposed project develops and tests a dynamic workplace-based depression intervention that is tailored to the specific social and behavioral needs of low- wage workers and enhanced with text message support for mood and physical activity. If found to be feasible and acceptable, this intervention could provide a scalable workplace program to reduce the adverse economic and health impacts of depression for low-wage workers and their employers.

PI_NAMEs: MCCURLEY, JESSICA LAUREN (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: acceptability and feasibility;Address;Adult;adverse outcome;arm;Behavior Therapy;Behavioral;Behavioral Sciences;Blood Pressure;Body mass index;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;care coordination;career;career development;Caring;Chronic;Clinical;clinically relevant;Cognitive Therapy;Coping Behavior;cost;Data;depressive symptoms;design;Development Plans;Diabetes Mellitus;disability;Disparity;Ecological momentary assessment;Economics;Educational Curriculum;Educational workshop;Effectiveness;efficacy trial;Employee;Employee Health;Employment;evidence base;Evidence based intervention;exercise intervention;feasibility testing;Feedback;Financial Hardship;Food;General Hospitals;Goals;Grant;Health;Health behavior;Health equity research;Health Promotion;High Prevalence;Hospitals;Housing;Impairment;implementation science;improved;Individual;Industry;Information Dissemination;innovation;Intervention;intervention delivery;intervention refinement;Intervention Trial;Interview;Low income;Low Income Population;low socioeconomic status;Massachusetts;Mental Depression;Mentorship;Methods;mHealth;Moods;Obesity;Occupations;Outcome;Participant;Phase;Physical activity;physical inactivity;Pilot Projects;pilot trial;poor sleep;Population;Positioning Attribute;preference;pressure;Prevalence;Preventive care;primary outcome;Process;programs;Provider;Publications;Randomized;randomized trial;Randomized, Controlled Trials;Research;Research Personnel;Risk;Risk Factors;scale up;Scientist;secondary outcome;skill acquisition;Sleep;sleep quality;social;social determinants;social disparities;social health determinants;Suggestion;Technology;telephone delivery;telephone session;Testing;Text;Text Messaging;text messaging intervention;texting support;therapy design;Time;Training;trial comparing;trial design;uptake;Wages;Waiting Lists;Wellness Program;Work;Workplace;Writing

PROJECT_TITLE: Be Well at Work-Plus: Engaging low-wage workers in the design and implementation of a depression and physical activity intervention

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PULLMAN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE Through the proposed research, we will determine if intraindividual cognitive variability can be used to identify early, pre-symptomatic signs of Alzheimer’s disease in adults with Down syndrome. The results of these studies may provide support for the translational application of intraindividual cognitive variability as well as the inclusion of DS individuals in anti-Alzheimer’s disease trials. Furthermore, the proposed work may have important implications for public health because the less invasive and easily disseminatable ways to detect the early signs of neurodegeneration in the DS population used here could also be applied to low-resource communities, enabling earlier interventions to reduce the impact of dementia on individuals, their families, and society.

PI_NAMEs: FONSECA, LUCIANA  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta deposition;Adult;Age;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapy;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Amyloid deposition;Area;autosomal dominant Alzheimer's disease;Biological Markers;Brazil;career;Cerebrospinal Fluid;Chronic Brain Damage;Clinical;Clinical Trials;Cognition;Cognitive;cognitive function;cognitive performance;cohort;Cohort Studies;Collaborations;Control Groups;Corpus striatum structure;cost;Data;Dementia;dementia risk;design;Deterioration;Diagnosis;Disease;Down's Syndrome;Early Diagnosis;Early identification;Early Intervention;Ethnic Population;executive function;Family;follow-up;Foundations;General Population;High Prevalence;high risk;high risk population;Impaired cognition;improved;Incidence;Individual;Intellectual functioning disability;International;Intervention;Knowledge;Linear Models;Link;Logistic Models;Longitudinal cohort;Longitudinal cohort study;Measures;Memory;Mentors;middle age;mild cognitive impairment;Modeling;Nerve Degeneration;Neurobiology;neuroimaging;neuropathology;Neuropsychological Tests;Neuropsychology;novel;novel marker;Outcome Measure;Pathology;Pathway interactions;Peptides;Performance;performance tests;Persons;Phase;Plasma;Population;Positron-Emission Tomography;pre-clinical;processing speed;programs;Public Health;Quality of life;recruit;Research;Research Design;research study;Resource-limited setting;risk prediction;sex;skills;Societies;Target Populations;tau Proteins;Testing;Therapy trial;Time;Training;translational applications;Universities;Visuospatial;Washington;Work;β-amyloid burden

PROJECT_TITLE: Intraindividual cognitive variability in aging adults with Down syndrome: associations with Alzheimer's disease plasma biomarkers, neuropathology and clinical dementia

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

PI_NAMEs: FISCH, KATHLEEN MARIE;JEPSEN, KRISTEN LYNN;LAURENT, LOUISE CHANG (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TITLE: Omics Data Generation Center (ODGC) for the Acute to Chronic Pain Signatures (A2CPS) Program


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Pain Research

PI_NAMEs: FISCH, KATHLEEN MARIE (contact)

PROJECT_TERMS: Acute;Agreement;biocomputing;Bioinformatics;Biological Assay;candidate marker;chronic pain;chronic pain management;Clinical;Collaborations;Collection;Communication;Complex;Computational Biology;Consultations;Data;Data Coordinating Center;data exchange;data integration;data management;data submission;design;Disease;Disputes;Elements;Ensure;experience;extracellular;Funding;Generations;Genetic;Genetic Predisposition to Disease;genetic variant;Genomic medicine;Genomics;Goals;Human Resources;Infrastructure;Institution;Institutional Review Boards;Intellectual Property;Laboratories;Lead;Leadership;lipidomics;Manuscripts;meetings;metabolomics;Metadata;Mission;Monitor;neuroimaging;Office of Administrative Management;operation;organizational structure;Pain;Participant;Persons;Physicians;Physiological;Policies;Population Genetics;Preparation;primary outcome;Procedures;programs;Progress Reports;Proteomics;Protocols documentation;psychosocial;Research;Research Personnel;Resolution;Resource Allocation;Resources;RNA;Sampling;Scientist;Services;stem cell biology;success;symposium;System;Systems Development;Training;Transfer Agreement;Translational Research;Travel;United States National Institutes of Health

PROJECT_TITLE: A2CPS Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ETTN-P]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Genetics;Pain Research;Prevention

PI_NAMEs: LAURENT, LOUISE CHANG (contact)

PROJECT_TERMS: Acute;Acute Pain;Adopted;Biological Markers;candidate marker;candidate selection;Cells;chronic pain;chronic pain management;Clinical;clinical center;Clinical Data;cohort;Collaborations;Collection;Communication;comparative;Data;Data Analyses;data analysis pipeline;data integration;Data Set;data standards;data submission;Detection;Development;extracellular;extracellular vesicles;Generations;Goals;Human;Human Resources;imaging biomarker;Knowledge;Laboratories;Libraries;Longitudinal cohort;Management Information Systems;Measurement;Mediation;Mediator;Metadata;metadata standards;Methods;MicroRNAs;miniaturize;Molecular;Multiomic Data;musculoskeletal injury;novel;Operative Surgical Procedures;Pain;pain chronification;pain signal;patient biomarkers;personalized strategies;predictive marker;Predisposition;Preparation;Prevention;Prevention strategy;primary outcome;Procedures;Process;programs;Protocols documentation;psychosocial;Quality Control;Quantitative Reverse Transcriptase PCR;recruit;Reproducibility;Reproducibility of Results;Research Design;Research Personnel;resilience;Resources;Risk;RNA;Running;sample collection;Sample Size;Sampling;skills;Stimulus;Testing;therapeutic target;Tissues;transcriptome sequencing;transcriptomics;transmission process;Validation;Work

PROJECT_TITLE: A2CPS ExRNA Component


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PI_NAMEs: LINDQUIST, MARTIN  (contact);WAGER, TOR D.

PROJECT_TITLE: Data Center for Acute to Chronic Pain Biosignatures


PI_NAMEs: LINDQUIST, MARTIN  (contact)

PROJECT_TERMS: Acute;Benchmarking;biosignature;chronic pain;Clinical;clinical center;clinical research site;Collaborations;Communication;Communities;cost effectiveness;Data;Data Analyses;data centers;Data Collection;data integration;data quality;data resource;data submission;design;Effectiveness;Enrollment;Environment;Evaluation;experience;Funding;Goals;Individual;Infrastructure;Lead;Leadership;Maintenance;Measures;meetings;member;Monitor;operation;outreach;Patients;Personnel Management;Principal Investigator;Productivity;programs;Recurrence;Reporting;Research;Research Personnel;Research Support;Resources;response;Schedule;Services;Site;sound;statistics;Structure;success;Translations;United States National Institutes of Health;Universities;Update;virtual;Vision;Work;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Neurosciences


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Mental Health;Neurosciences;Pediatric

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Between 7 and 10% of children demonstrate severe and persistent mathematical disabilities (MD), with adverse life-long consequences for employability, socio-economic wellbeing, health, and life expectancy. The overarching objective of our research is to characterize the brain and cognitive mechanisms underlying atypical development of numerical skills in children and adolescents with MD. Our proposed studies will contribute foundational knowledge necessary for reducing the public health burden of learning disabilities.

PI_NAMEs: MENON, VINOD  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Acceleration;Address;Adolescent;Adult;Age;Arithmetic;Attention;Brain;Brain imaging;Child;Childhood;Cognition;Cognitive;Development;Diagnosis;elementary school;Etiology;Exhibits;Foundations;Growth;Health;Health Resources;high school;Impairment;Individual;innovation;Instruction;Intervention;junior high school;Knowledge;Learning Disabilities;Life Expectancy;Lobe;Longitudinal cohort;longitudinal design;low health literacy;Maps;mathematical ability;mathematical difficulties;Mathematics;mathematics disability;Measures;Medial;Memory;Memory impairment;Modeling;multimodality;neural;Neurocognitive;Outcome;Parietal;Pathway interactions;Pattern;peer;Personal Satisfaction;poor health outcome;Problem Solving;Psyche structure;Public Health;Research;response;Retrieval;Risk Factors;skills;socioeconomics;System;Testing;university student;Visuospatial

PROJECT_TITLE: Longitudinal Neurocognitive Studies of Mathematical Disabilities: Outcomes and Trajectories

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Clinical and molecular heterogeneity of Alzheimer's disease is increasingly recognized as a major factor impacting diagnosis, treatment, and most importantly the design and testing of new drugs. Despite the substantial effort in identifying AD subtypes, there is currently no identified association between pathological subtypes, cognitive function, and molecular subtypes. The overarching goal of this K25 proposal is to identify and characterize molecular subtypes of Alzheimer’s disease associated with cognitive function by leveraging high throughput omics data from different brain regions and cohorts, machine learning, digital deconvolution, and traditional statistical approaches.

PI_NAMEs: ETELEEB, ABDALLAH M (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Address;Advisory Committees;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;Animal Model;Autopsy;Award;Biological;Biological Markers;biological systems;Biology;biomarker identification;Blood;blood-based biomarker;Brain;Brain region;cerebral atrophy;Cerebrospinal Fluid;Chromatin Remodeling Factor;Clinical;Clinical Trials;clinically relevant;Cognitive;cognitive function;cohort;Data;data integration;Data Set;Dedications;Dementia;Dementia with Lewy Bodies;design;Development;Diagnosis;digital;Disease;Disease Progression;disorder subtype;DNA Methylation;Doctor of Philosophy;Educational workshop;effective therapy;Encapsulated;Environment;Epigenetic Process;experience;Feedback;Foundations;Funding;Future;Genes;Genetic;Genetic Markers;genetic risk factor;Genomics;Goals;Heterogeneity;histone modification;Human;human old age (65+);illness length;Impaired cognition;improved;Individual;innovation;insight;Journals;K-Series Research Career Programs;Knowledge;Leadership;Learning;Machine Learning;Malignant Neoplasms;Medical Research;medical schools;Mentors;Mentorship;Modality;model organism;Modeling;Molecular;molecular marker;Molecular Profiling;molecular subtypes;mouse model;Multiomic Data;multiple datasets;Nerve Degeneration;Neurodegenerative Disorders;Neurology;neuropathology;Neurosciences;novel;novel therapeutics;Parkinson's Dementia;Pathologic;Pathology;Pathway interactions;patient subsets;Pharmaceutical Preparations;potential biomarker;precision medicine;Proteomics;Regulation;Reporting;Research;Risk;sex;skills;spatiotemporal;specific biomarkers;symposium;tau Proteins;Techniques;Testing;Training;Training Programs;trait;transcriptomics;United States;Universities;Untranslated RNA;Validation;Washington;Work

PROJECT_TITLE: Identification and characterization of molecular subtypes of Alzheimer's disease associated with cognitive function through cross-omics data integration

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Narrative Near-infrared spectroscopy (NIRS) measures cerebral blood oxygenation using light emitters and sensors placed on the surface of the scalp. Meanwhile, electroencephalography (EEG) measures electrophysiological brain activation created when neurons in the brain are firing. Those techniques are portable, low-cost, and versatile technology that is well suited for real-time detection of brain activity and brain computer interface (BCI) applications, however, neither is without limitations. In this Trail Blazer R21 proposal, we propose a novel approach in which instead of estimating the patterns of brain activity de novo for a task, we use brain activity patterns derived from meta-analysis of existing fMRI databases to construct a novel data compression model allowing us to implement a real-time, task agnostic, projection of fNIRS-EEG onto a low dimensional parameter space associated with each of the six key cognitive domains defined in the recent DSM-V.

PI_NAMEs: SANTOSA, HENDRIK  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Area Under Curve;Attention;Back;Blood;blood oxygen level dependent;Brain;brain computer interface;Brain imaging;Brain Mapping;Brain region;Categories;cerebral blood volume;Cerebrum;Classification;clinical translation;Cognitive;Communities;Complex;connectome;cost;cost comparison;Data;Data Compression;Databases;Dedications;Detection;Dimensions;DSM-V;Electroencephalography;Electrophysiology (science);Environment;executive function;Freedom;Frequencies;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Human;Human Activities;Image;imaging approach;improved;innovation;interest;Knowledge;Label;Language;Lead;Learning;Light;Linear Models;Magnetic Resonance Imaging;Maps;Mathematics;Measurement;Measures;Memory;Meta-Analysis;Metadata;Methods;Modality;Modeling;Motor;multimodal fusion;multimodality;Near-Infrared Spectroscopy;neural;neuroimaging;Neurons;Noise;novel;novel strategies;Pattern;Penetration;Performance;portability;predictive modeling;Protocols documentation;Publications;Receiver Operating Characteristics;Relaxation;Reporting;repository;Reproducibility;Resolution;Rest;Scalp structure;Sensitivity and Specificity;sensor;Short-Term Memory;Signal Transduction;social cognition;Surface;Techniques;Technology;Testing;Time;Training

PROJECT_TITLE: Cognitive Domains Classification Using fNIRS-EEG

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(91)S]


ORG_CITY: Washington

ORG_NAME: POPULATION REFERENCE BUREAU

ORG_STATE: DC

PHR: Project Narrative A Coordinating Center for the NICHD Population Dynamics Centers Research Infrastructure Program will improve the translation and dissemination of major peer-reviewed findings from population dynamics research to multiple audiences, facilitating the adoption of relevant findings for health research and practice. It will also improve synergy across the Population Dynamics Centers, enhancing the productivity and scientific impact of the Centers and of population dynamics research overall.

PI_NAMEs: MATHER, MARK  (contact)

PROGRAM_OFFICER_NAME: CLARK, REBECCA L

PROJECT_TERMS: Adoption;Communication;cost effective;Decision Making;Demography;Educational workshop;empowerment;Event;Feedback;Fostering;Funding;Health;improved;Incubators;Measures;meetings;Mentors;Methods;National Institute of Child Health and Human Development;news;Newsletter;peer;peer learning;Peer Review;Performance;Periodicals;Policies;Population;Population Dynamics;population health;Population Research;Productivity;programs;repository;Reproductive Health;Research;Research Infrastructure;Research Personnel;Series;social media;statistics;Surveys;symposium;synergism;Translating;Translations;web site;Writing

PROJECT_TITLE: Center for Public Information on Population Research


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE The goal of this application is to develop a behavioral and experimental approach to study the cellular-level mechanisms that combine proprioceptive and motion signals on the skin to generate tactile motion representations in different reference frames. We will record single-unit activity in non-human primates (NHPs) trained to discriminate tactile motion on a finger in different reference frames (e.g., relative to the center of their body, or relative to another finger on the hand), and with their hands placed in different postures (e.g., hand supinated vs. pronated). Our project will demonstrate the first experimental paradigm in NHPs to study the neural areas and mechanisms that produce flexible (i.e., reference frame-specific) representations of tactile motion.

PI_NAMEs: GOMEZ-RAMIREZ, MANUEL  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: analog;Animals;Area;Bayesian Analysis;Behavior;Behavioral;Behavioral Paradigm;Body part;Brain;Cells;Chronic;Cognitive;computer framework;Computer Models;Cues;Cutaneous;Data;density;discrimination task;experimental study;Feedback;Fingers;flexibility;Funding;generative models;Goals;Grant;grasp;Hand;haptics;Human;indexing;Judgment;Knowledge;Learning;Location;Medial;Mediating;Modeling;Molecular Conformation;Motion;Motion Perception;Motor;neural;neural model;neuromechanism;Neurons;neurophysiology;neurotransmission;nonhuman primate;object motion;Pattern;Perception;Phase;Play;Population;Positioning Attribute;Posture;Proprioception;Protocols documentation;Psychophysics;response;Role;sensory feedback;Signal Transduction;Skin;somatosensory;Somatosensory Cortex;Source;Speed;Stimulus;Tactile;tactile stimulation;Temporal Lobe;Testing;Thumb structure;Time;Touch sensation;Training;Visual Motion;Work

PROJECT_TITLE: Developing an Experimental and Computational Framework for Studying Neural Representations of Tactile Motion on the Hand

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE This proposal aims to study the regulatory mechanisms controlling heparin biosynthesis in order to bioengineer a safer, recombinant form of anticoagulant heparin in cultured cells. The research is highly relevant to public health because the recombinant heparin products generated in these studies represent new potential therapeutics for improving patient care and minimizing heparin-induced thrombocytopenia (HIT), a life- threatening, immune-mediated complication to heparin therapy.

PI_NAMEs: WEISS, RYAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: acute care;Affect;Affinity;Anabolism;Animal Sources;Animals;Antibodies;Anticoagulants;Antidotes;Binding;Binding Sites;Biological;Biological Assay;Biological Products;Biomedical Engineering;Blood Platelets;Candidate Disease Gene;candidate validation;Categories;Cell Line;Cell Physiology;Cell surface;Cells;Cellular biology;chemokine;China;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coagulation Process;Complex;Complication;Connective Tissue;CRISPR screen;Cultured Cells;Deep Vein Thrombosis;Development;Engineering;enhancing factor;Enzymes;Epitopes;Exhibits;experience;Factor Xa;Family suidae;Flow Cytometry;functional genomics;Future;Genes;Genetic;genetic testing;genome wide screen;genome-wide;genome-wide analysis;Goals;Guide RNA;Hemorrhage;Heparan Sulfate Biosynthesis;Heparin;heparin-induced thrombocytopenia;Heparitin Sulfate;Immune;immunoreactivity;improved;Incidence;Individual;inhibitor;innovation;Intestines;Knock-out;Knowledge;Life;Ligand Binding;Mammalian Cell;Mass Spectrum Analysis;mast cell;Mediating;metabolic engineering;Methods;Modification;Molecular;Mucous Membrane;National Heart, Lung, and Blood Institute;novel;Oligosaccharides;Operative Surgical Procedures;Oral;Outcome;overexpression;Pathway interactions;Patient Care;Patients;PF4 Gene;Pharmaceutical Preparations;Plasma Proteins;prevent;Prevention;Process;Production;Property;Public Health;Pulmonary Embolism;Recombinants;Regulation;Reporting;Research;Risk;RNA library;screening;Serine Proteinase Inhibitors;Site;Sorting;Source;stable cell line;Sulfate;supply chain;Therapeutic;Thrombin;Transcription Repressor;whole genome;Work

PROJECT_TITLE: Genome-wide Analysis of Anticoagulant Heparin Sulfate for Bioengineering Heparan

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Clinical Research;Emergency Care;Health Services;Pediatric;Physical Injury - Accidents and Adverse Effects

ORG_CITY: PORTLAND

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Reducing mortality in children using emergency services is a critical public health priority. We will conduct a mixed methods evaluation of emergency department (ED) pediatric readiness using two multi-state cohorts of children and over 1,500 hospitals to assess which components of ED readiness improve short- and long-term survival, and empirically develop a new global measure of readiness based on these findings. Finally, we will use positive deviance methods and 150 interviews with key informants across 30 hospitals to identify specific processes of care and key aspects of pediatric readiness among EDs with better-than-expected survival.

PI_NAMEs: NEWGARD, CRAIG D. (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Admission activity;Automobile Driving;Budgets;care coordination;care systems;Caring;Cause of Death;Child;Child Care;child services;Childhood;Childhood Injury;clinical practice;cohort;Complement;Critically ill children;Data;Data Science;Death Records;design;Emergency Care;Emergency Department evaluation;Emergency department visit;Emergency medical service;Equipment;Evaluation;Expert Opinion;General Hospitals;Grant;Guidelines;Health system;Hospital Mortality;hospital organization;Hospitalized Child;Hospitals;Human Resources;improved;informant;Injury;Institute of Medicine (U.S.);Interview;Link;Machine Learning;machine learning method;Measures;Medical;Methods;mortality;multidisciplinary;National Health Policy;National Institute of Child Health and Human Development;novel;Outcome;Outcome Measure;Participant;Patients;pediatric department;pediatric emergency;Policies;preventable death;Process;programs;Public Health;public health priorities;Qualitative Methods;R24;Readiness;Reporting;Research Design;Research Infrastructure;Resources;rural setting;Safety;Sampling;Structure;survival prediction;Translating;Trauma;trauma care;trauma centers;Triage;United States Health Resources and Services Administration;Vital Statistics

PROJECT_TITLE: Components of emergency department pediatric readiness associated with short- and long-term survival among children: a mixed methods evaluation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(91)S]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Amyloid-bodies and the Evolution of Malignancies Narrative Cancer cells encounter various adverse environmental conditions during tumorigenesis. Our group has recently discovered that cancer cells solidify their proteins to enter spore-like state, like how yeast undergo sporulation. By this process of protein solidification, cancer cells can resist the harsh conditions of the tumor microenvironment.

PI_NAMEs: LEE, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Acidosis;Amyloid;amyloid formation;amyloidogenesis;Animal Model;Applications Grants;Balbiani Body;Biochemical;Biological;Biological Assay;biophysical properties;cancer cell;Catalytic Domain;cell assembly;Cell Cycle Regulation;Cells;Clinical;Data;Dedications;Depressed mood;Detection;Dinucleotide Repeats;DNA biosynthesis;DNA-Directed DNA Polymerase;Elements;Environment;Enzyme Activation;Enzymes;Evolution;extracellular;fascinate;Genetic Transcription;Germ Cells;granule cell;Growth;Human;Human Genome;Hypoxia;Immobilization;in vivo;Junk DNA;Liquid substance;Malignant - descriptor;Malignant Neoplasms;malignant phenotype;Mediating;Membrane;Metabolic;metabolic depression;Metabolism;Names;Nature;neoplastic cell;Normal tissue morphology;Nuclear Envelope;Nucleic Acids;Oncogenic;Organelles;Participant;Pathway interactions;Phase Transition;Phenotype;Physical condensation;Physiological;Play;Process;programs;Proliferating;Protein Array;Proteins;Proteome;Proteomics;Publishing;Reporting;Reproduction spores;response;Ribosomal RNA;Ribosomes;RNA;Role;Sampling;Signal Transduction;Solid;solid state;Stimulus;Stress;stress granule;stressor;System;Tail;Testing;tumor;tumor microenvironment;tumor progression;tumorigenesis;tumorigenic;Untranslated RNA;Xenopus;Yeasts

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH The proposed research is relevant to public health because the proposed novel neural control for powered prosthetic ankle will improve balance control, postural stability, and balance confidence in individuals with lower limb amputation. This, in turn, improves their community participation and quality of life. The project is relevant to the part of the NIH’s mission such that demonstrating the effectiveness of neural prosthesis control will help individuals with lower limb amputation to improve the capacity to maintain balance, which reduces risk of fall, encourages prosthesis usage, and improves the health of lower limb amputees.

PI_NAMEs: HUANG, HE  (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: active lifestyle;Activities of Daily Living;Address;Amputees;Ankle;ankle prosthesis;Biological;Biomechanics;Clinical;clinically significant;Cognitive;cognitive load;cognitive process;Community Participation;design;Devices;Effectiveness;Electromyography;Equilibrium;fall risk;falls;fear of falling;Freedom;Future;Goals;Health;improved;Incidence;Individual;innovation;Joint Prosthesis;Joints;Knee;Knowledge;Lead;limb amputation;Limb Prosthesis;Limb structure;Locomotion;Lower Extremity;Mechanics;Mission;Motor;motor control;motor function improvement;motor learning;Muscle;Musculoskeletal Equilibrium;neural;neural prosthesis;Neuromechanics;neuromuscular;neuroregulation;neurotransmission;novel;operation;Outcome;Participant;Pattern;Periodicity;Physical therapy;Population;Positioning Attribute;Posture;powered prosthesis;prevent;Production;programs;Prosthesis;prosthesis control;Public Health;Quality of life;Randomized, Controlled Trials;Rehabilitation therapy;Reporting;Research;Residual state;Resources;restoration;Risk Reduction;Robotics;Single-Blind Study;Structure;success;Technology;Time;Training;United States National Institutes of Health;Walking

PROJECT_TITLE: Toward Restoration of Normative Postural Control and Stability using Neural Control of Powered Prosthetic Ankles

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-H(03)M]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE The increased risk of early childhood obesity remains a pressing public health issue especially in low-income families. This study proposes a novel approach by developing and testing digitally delivered early childhood obesity prevention modules in an existing home visitation program over a 1 year period to improve obesogenic behaviors and prevent overweight and obesity of at-risk infants.

PI_NAMEs: MOBLEY, AMY R (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: 1 year old;Abbreviations;acceptability and feasibility;Address;Adult;Affect;Age;Attitude;Behavior;behavior change;Biometry;Birth;Breast Feeding;cardiovascular disorder risk;Cellular Phone;Child;Child Development;Childhood;Communities;comorbidity;Conceptions;cost effective;COVID-19;critical period;Data;digital;digital delivery;digital intervention;digital technology;E-learning;early childhood;Educational Curriculum;Enrollment;Evaluation;evidence base;Family;Family member;Fathers;Feasibility Studies;feeding;Florida;Foundations;Friends;Future;Goals;Health;Health Personnel;high risk;Home;Home visitation;Image;improved;Infant;innovation;Interdisciplinary Study;Intervention;Interview;Juice;Learning Module;Length;Life;literacy;Low income;lower income families;Mediator;member;Methods;Modeling;Mothers;novel strategies;Nurses;nutrition;Obesity;obesity development;obesity in children;obesity prevention;obesity risk;obesogenic;Overweight;parenting intervention;Parents;Pediatrics;Persons;Pilot Projects;pilot trial;Population Heterogeneity;preference;Prevalence;prevent;Prevention program;preventive intervention;primary outcome;programs;Protocols documentation;Psychology;Public Health;Randomized;randomized trial;recruit;Research;Resources;response;Risk;Risk Factors;Schedule;secondary outcome;Series;skills;Sleep;Social Network;Social Workers;Solid;Technology;technology intervention;Testing;Training;treatment effect;Treatment Efficacy;trend;tv watching;Underserved Population;usability;Weight;Work

PROJECT_TITLE: A pilot feasibility study of digitally delivered modules focused on preventing the development of obesity during the first year of life within an existing statewide home visitation program

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(JA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Primary Health Care;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The proposed IMPOWR Research Center at Montefiore-Einstein (IMPOWR-ME) will create a multidisciplinary and synergistic program of research to test multimodal treatments that address both chronic pain and opioid use disorder. IMPOWR-ME will generate critical knowledge about the effectiveness, implementation, and cost- effectiveness of providing onsite yoga classes or physical therapy in methadone treatment programs, providing Acceptance and Commitment Therapy and/or a care management smartphone app for individuals in primary care-based buprenorphine treatment, and choosing microdosing or standard buprenorphine induction for hospitalized patients with chronic pain and opioid use disorder or opioid misuse. Patients with lived experience with chronic pain and/or opioid use disorder, patient and policy advocates, payors, and health system partners will be engaged in all stages of the research. IMPOWR-ME is well-positioned to become a long-lasting hub for stakeholder-engaged research with multidisciplinary senior and early stage investigators focused on reducing overdose through better treatments for OUD and CP.

PI_NAMEs: ARNSTEN, JULIA H.;GABBAY, VILMA ;STARRELS, JOANNA L. (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: acute care;Address;Adoption;Advocate;Area;biopsychosocial factor;black patient;Black Populations;Buprenorphine;buprenorphine treatment;care seeking;Caring;chronic pain;chronic pain management;chronic pain patient;Clinical;clinical care;Collaborations;Combined Modality Therapy;Communities;comorbidity;cost effective;cost effectiveness;County;Data Analyses;Data Analytics;data management;Death Rate;design;Dissemination and Implementation;Dose;effective intervention;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness testing;effectiveness/implementation trial;Ensure;Equity;Evidence based practice;experience;flexibility;future implementation;Goals;Grant;Health;health care settings;Health Services Accessibility;Health system;Helping to End Addiction Long-term;Hispanic;Hispanic Populations;hospital care;Hospitalization;Hybrids;implementation trial;implementation/effectiveness;Improve Access;Individual;innovation;Institution;integrated care;Interdisciplinary Study;Intervention;Knowledge;Leadership;Lived experience;Maintenance;Managed Care;Mental Health;Mentors;Methadone;methadone treatment;mindfulness;Morbidity - disease rate;mortality;multi-component intervention;multidisciplinary;multimodality;Neighborhoods;New York City;novel;Opiate Addiction;opioid epidemic;opioid misuse;opioid mortality;opioid treatment program;opioid use disorder;opioid withdrawal;Outcome;Overdose;overdose death;Overdose reduction;Pain Research;Participant;Patient-Focused Outcomes;Patients;Persons;Physical Function;Physical therapy;Physiological;Pilot Projects;Policies;Policy Maker;Population;Positioning Attribute;Poverty;Primary Care;primary care clinic;programs;Psychiatry;psychologic;Public Health;Qualitative Methods;Quality of life;racial diversity;racism;Recording of previous events;Recovery;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;response;Site;smartphone application;social factors;social health determinants;social stigma;syndemic;Testing;three-arm trial;Time;Training;treatment adherence;treatment program;two-arm trial;United States;Vulnerable Populations;Yoga

PROJECT_TITLE: Integrated Care for Chronic Pain and Opioid Use Disorder: The IMPOWR Research Center at Montefiore/Einstein (IMPOWR-ME)


ORG_CITY: NEW ORLEANS

ORG_NAME: OBATALA SCIENCES, INC.

ORG_STATE: LA

PHR: The current application combines exposure to fundamental concepts in both biotechnology research and entrepreneurial development and provides a pathway to create opportunity for a more diverse workforce. The outcomes will provide a fundamental appreciation for the ethics of responsible conduct in research and a mechanism to reinforce some of the necessary elements of success within research in biotechnology and entrepreneurship.

PI_NAMEs: FRAZIER, TRIVIA  (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: Academia;Academic Medical Centers;Achievement;Address;African American;Age;Asian Americans;Award;Biotechnology;Businesses;career;Caucasians;Cells;Clinical;clinical translation;commercialization;Communities;community college;Complement;Continuing Education;Core Facility;cost;curriculum development;Dedications;demographics;design;Development;Diverse Workforce;Economic Development;Educational Curriculum;Educational process of instructing;Elements;Employee;Employment Opportunities;Entrepreneurship;Ethics;Exposure to;Foundations;Funding;Future;Goals;Good Manufacturing Process;Growth;high standard;Hispanic Americans;Human;Human Resources;Immersion;Incubators;Individual;Industry;innovation;insight;Intention;Internships;Laboratories;laboratory facility;Louisiana;manufacture;Medical;Methods;Middle Eastern;Minority;Modeling;next generation;operation;Organizational Culture;Outcome;Pathway interactions;Perception;Personal Growth;Positioning Attribute;Privatization;programs;recruit;regenerative;Regenerative Medicine;regenerative therapy;Research;Research Institute;Research Personnel;responsible research conduct;Role;Science;Scientist;Small Business Innovation Research Grant;Students;success;Therapeutic;Tissues;tool;Training;Training Programs;Universities;Woman;Work

PROJECT_TITLE: Getting Regenerative Medical Biotech REDI to Age


ORG_CITY: BOSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: PROJECT NARRATIVE Functional magnetic resonance imaging (fMRI) research has transformed our understanding of human brain function and disease, but recent work has exposed an endemic lack of statistical power (i.e., ability to detect effects of interest) and a need for power analysis tools that meet the demands of the typical user. We propose to create a web-based power calculator tailored to typical fMRI studies that only requires the user to specify information readily available to them. By enabling researchers to more easily and accurately plan studies for desired levels of power, this power calculator will promote more robust and reproducible findings in the field.

PI_NAMEs: NOBLE, STEPHANIE MARIE (contact)

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: Address;Algorithmic Analysis;Algorithms;base;Benchmarking;Brain;BRAIN initiative;career;Characteristics;Complex;Computer software;Data;Data Set;Databases;Dedications;design;Development;Dimensions;Disease;Documentation;Functional Magnetic Resonance Imaging;Funding;Human;Individual;interactive tool;interest;International;Internet;Literature;Maps;Memory;Methodology;Methods;Modeling;Modernization;Online Systems;Participant;Patients;Pilot Projects;power analysis;Procedures;Production;Professional Competence;Recommendation;Reproducibility of Results;Research;Research Design;Research Personnel;Sample Size;Sampling;Sampling Studies;Scanning;simulation;Specific qualifier value;study characteristics;symposium;Testing;tool;Training;web app;web-based tool;Work

PROJECT_TITLE: Empirical Power Analysis Tool for fMRI


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE In developing B and T lymphocytes, functional antigen receptor genes are assembled from component gene segments by V(D)J recombination through a DNA cleavage and joining mechanism. In this project, we will decipher patterns in DNA sequences that govern the efficacy of V(D)J recombination using a recently developed cellular recombination assay that is coupled with a high throughput sequencing approach. Findings from this study will be important for elucidating how the antigen receptor repertoire in the adaptive immune system is formed, as well as the basis for aberrant recombination reactions that can lead to oncogenic chromosomal rearrangements.

PI_NAMEs: RODGERS, KARLA K (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Adaptive Immune System;Address;Antigen Receptors;B-Lymphocytes;base;Base Pairing;Binding;Binding Proteins;Biochemical;Biological Assay;Cells;Chromatin;Chromosomal Rearrangement;Complex;Coupled;defined contribution;Development;Disease;DNA;DNA Double Strand Break;DNA Sequence;Elements;Environment;Ephrin-A5;Equilibrium;Event;experimental study;Gene Modified;Gene Proteins;Gene Rearrangement;Genes;Genetic Recombination;Genetic Transcription;Genome;Genome Stability;High-Throughput Nucleotide Sequencing;Histone H3;IgK;improved;In Vitro;insight;Libraries;Lymphocyte;Mediating;Methods;mouse model;Mus;mutant;Mutate;next generation sequencing;Nonhomologous DNA End Joining;Oncogenic;Outcome;Pattern;Peptide Signal Sequences;Process;promoter;Reaction;Receptor Gene;recombinase;Risk;Shapes;Signal Transduction;Site;System;T-Cell Development;T-Lymphocyte;Testing;V(D)J Recombination;Variant

PROJECT_TITLE: DNA sequence selectivity in conventional and aberrant V(D)J recombination

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Nutrition;Post-Traumatic Stress Disorder (PTSD);Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Acute are by information comorbid stressors affect energy homeostasis via brain and body interactions. The proposed experiments  designed to identify key changes in energy metabolism in male and female mice after acute stressor manipulating a key central nervous system region that drives stress-related behaviors. This basic is critical for developing novel strategies to treat stress-associated conditions that are with energy dysregulation.

PI_NAMEs: RAJBHANDARI, ABHA K (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Ablation;Acute;acute stress;adenylate;Adipose tissue;Affect;Anatomy;Animals;Area;Behavior;Behavioral;Behavioral Model;Bioenergetics;biological adaptation to stress;Biology;Blood;Brain;Brain Stem;Brown Fat;Cells;Central Nervous System;Chemicals;Chronic stress;comorbidity;COVID-19 pandemic;Data;Desire for food;Disease;Energy Metabolism;Enterobacteria phage P1 Cre recombinase;environmental stressor;Experimental Designs;feeding;Female;fighting;food consumption;Freezing;Fright;Future;Gatekeeping;Genes;Genetic Polymorphism;Homeostasis;Human;In Situ Hybridization;Indirect Calorimetry;Intake;knock-down;Learning;Link;Lipolysis;locus ceruleus structure;loss of function;LoxP-flanked allele;mad itch virus;male;Measurement;Measures;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Mitochondria;molecular targeted therapies;mouse model;Mus;Nature;nerve supply;Neurons;Neuropeptide Receptor;Neuropeptides;novel;novel strategies;Oxygen;PACAPR-1 protein;Peptides;Physiological;pituitary adenylate cyclase activating polypeptide;Pituitary Gland;Population;post-traumatic stress;Process;programs;Respiration;response;retrograde transport;Rodent;Rodent Model;Role;sex;Sex Differences;sexual dimorphism;Societies;Stress;stress related disorder;stressor;Systems Biology;Techniques;Testing;Thermogenesis;Tissues;tool;Transcript;transcriptomics;translational model;uncoupling protein 1;Viral;virus testing;Water consumption;Woman;women versus men;Work

PROJECT_TITLE: Linking stress-associated brain and adipose functions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P(54)]


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Vanderbilt-Ingram Cancer Center (VICC) is a matrix center that integrates all of Vanderbilt’s cancer-related expertise and resources in order to deliver its mission of alleviating cancer death and suffering through pioneering research; innovative patient-centered care; and evidence-based prevention, education and community initiatives. This mission is accomplished through translation of exceptional cancer research into interventions for the prevention, diagnosis and treatment of cancer. The Cancer Center Support Grant provides infrastructure to facilitate multidisciplinary basic, clinical and population-based research, to advance VICC discoveries to cancer patients and the community, and to educate and train the next generation of cancer investigators and workforce.

PI_NAMEs: PARK, BEN HO (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Academic Medical Centers;Address;anti-cancer research;Antineoplastic Agents;Arts;Award;Basic Science;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer epidemiology;cancer health disparity;Cancer health equity;Cancer Patient;cancer prevention;cancer therapy;care providers;career;Caring;Catchment Area;Cell Proliferation;Cessation of life;Clinical;clinical investigation;clinical practice;Clinical Research;Collaborations;Communities;community engagement;Community Outreach;Dedications;Diagnosis;Discipline of Nursing;disorder control;disparity reduction;drug discovery;Early Diagnosis;Education;Education and Outreach;Engineering;Ethnic Origin;Evaluation;evidence base;Evidence based intervention;Faculty;Funding;Future;Genome;Genomics;geographic disparity;graduate student;Grant;Growth;Guidelines;Health;Health equity research;host neoplasm interaction;Informatics;Infrastructure;innovation;Institution;Intervention;Investments;Lead;Leadership;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Medical center;medical schools;Medicine;member;Mission;Modeling;multidisciplinary;National Cancer Program;NCI Center for Cancer Research;next generation;Oncology;Organization administrative structures;Outcome;Patient Care;Patient-Centered Care;Patients;Peer Review;Population Research;Postdoctoral Fellow;precision oncology;Prevention;Productivity;programs;Race;recruit;Research;Research Activity;research facility;Research Personnel;Resource Sharing;Resources;Schools;Science;Signal Transduction;socioeconomic disparity;Strategic Planning;success;Technology;Training;Translating;Translational Research;Translations;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Students who participate in this program will receive rigorous training in fundamental areas of pharmacology, physiology, molecular and structural biology and drug discovery, as well as participate in cutting-edge research that examines the mechanisms of action of drugs that are either currently in use or being developed to treat a variety of human diseases. At the core of the training program, high level emphasis will be placed on mentorship, student development in the ethical conduct of research, inclusivity and wide-ranging career guidance. The knowledge gained by these trainees will have a direct impact on human health as they apply this knowledge as basic researchers, clinicians, educators, business leaders, intellectual property specialists or public policy advocates in the development and implementation of safe and effective drugs.

PI_NAMEs: JACOB, TIJA C. (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TITLE: Predoctoral Training in Pharmacological Sciences (Resubmission)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Cancer

PHR: ADMINISTRATIVE CORE 001 – VANDERBILT-INGRAM CANCER CENTER ADMINISTRATION PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Administrative Core.

PI_NAMEs: SCHAUM, JULIA C (contact)

PROJECT_TERMS: analytical tool;anti-cancer research;Award;Basic Science;Budgets;Cancer Center;Cancer Center Support Grant;cancer health disparity;Cancer Intervention;career;career development;Caring;Cessation of life;Clinical Research;clinical translation;Clinical Trials;Cohort Studies;Collaborations;Communication;Communities;community engagement;Community Outreach;community partners;Data;Data Analytics;data dashboard;data warehouse;Development;Education;Educational workshop;Evaluation;Event;evidence base;Extramural Activities;Faculty Recruitment;faculty support;Family;Fostering;Funding;Funding Mechanisms;Grant;Group Meetings;Informatics;innovation;Institution;Interdisciplinary Study;Intervention Trial;Leadership;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;medical schools;meetings;member;Mission;National Clinical Trials Network;Newsletter;operation;outreach;Patient advocacy;Patient Care;Patient-Centered Care;Patients;Performance;Philanthropic Fund;Play;Population Research;Prevention;Process;programs;Progress Reports;Publications;Recommendation;Reporting;Research;Research Personnel;Research Support;Resource Sharing;Resources;Role;Science;Services;Specialized Program of Research Excellence;Strategic Planning;Students;Tennessee;tool;Training;Training and Education;Translational Research;Universities;Visualization;Visualization software;working group

PROJECT_TITLE: Administrative Core


PHR: CORE 001 – CANCER RESEARCH CAREER ENHANCEMENT AND RELATED ACTIVITIES PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Cancer Research Career Enhancement and Related Activities.

PI_NAMEs: WILLIAMS, CHRISTOPHER S. (contact)

PROJECT_TERMS: Active Learning;Address;Advisory Committees;anti-cancer research;Area;Basic Science;Cancer Biology;cancer care;Cancer Center;Cancer Center Support Grant;cancer education;care providers;career;career development;Catchment Area;Cessation of life;Clinical;clinical practice;Clinical Research;Clinical Sciences;clinical training;Communities;Complement;Creativeness;Dedications;Development;Doctor of Philosophy;early-career faculty;Ecosystem;Education;Education and Outreach;education research;Educational Activities;Educational Curriculum;Ensure;Environment;Ethics;evidence base;Extramural Activities;Faculty;Financial Support;Foundations;Funding;Future;graduate student;Grant;Growth;Incidence;Individual;Infrastructure;innovation;Institution;Investments;kindergarten;Lead;Leadership;learning strategy;literacy;Malignant Neoplasms;Medical Students;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Mission;Modeling;Modernization;Morbidity - disease rate;mortality;National Research Service Awards;NCI Center for Cancer Research;next generation;Outcome;Patient Care;Patient-Centered Care;Peer Review;Physicians;population based;Population Heterogeneity;Population Sciences;Postdoctoral Fellow;Preparation;Prevention;profession allied to medicine;programs;recruit;Research;Research Personnel;Research Training;Resources;responsible research conduct;Rural;Scientist;Series;skills;Students;Study Section;Tennessee;Training;Training Activity;Training and Education;training opportunity;Training Programs;Translational Research;Translations;twelfth grade;undergraduate student;Underrepresented Minority;Vision;Writing


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities

PHR: CORE 002 – ANIMAL AND HUMAN IMAGING SHARED RESOURCE PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Animal and Human Imaging Shared Resource.

PI_NAMEs: PETERSON, TODD E (contact)

PROJECT_TERMS: Address;Animal Cancer Model;Animal Experimentation;animal imaging;Animal Model;Animals;biomedical imaging;Breast;Cancer Center Support Grant;cancer clinical trial;cancer imaging;Clinical;clinical imaging;Clinical Trials;clinically relevant;Collaborations;Data;Data Analyses;Dedications;design;Development;Effectiveness;Ensure;Environment;Equipment;Event;Experimental Designs;experimental study;Faculty;Funding;gastrointestinal;Goals;Good Manufacturing Process;Healthcare;Histology;Human;human imaging;human model;Image;Image Analysis;imager;imaging facilities;imaging modality;imaging probe;imaging science;imaging scientist;imaging study;imaging system;Imaging Techniques;improved;in vivo;Individual;innovation;Institution;instrument;Investigational Drugs;Investigational New Drug Application;Isotopes;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Neoplasms;Mentorship;method development;Methods;Mission;Modality;Molecular;Monitor;multimodality;Non-Invasive Detection;non-invasive imaging;novel;Nuclear;Optics;Patients;PET/CT scan;Phase;Physicians;Positron-Emission Tomography;pre-clinical;precision oncology;Preparation;Production;programs;Proteomics;Protocols documentation;quantitative imaging;Radiochemistry;Radiopharmaceuticals;Reproducibility;Research;Research Personnel;Resource Sharing;Resources;response;responsible research conduct;Scientist;Services;single photon emission computed tomography;Specialized Program of Research Excellence;Students;System;Talents;The Vanderbilt-Ingram Cancer Center at the Vanderbilt University;Time;Tracer;Training;tumor;tumor metabolism;Ultrasonography;ultrasound;Universities


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

PHR: CORE 003 – BIOANALYTICS AND PROTEOMICS SHARED RESOURCE PROJECT NARRATIVE Per the PAR-13-386 FOA, the project narrative is not applicable for the Bioanalytics and Proteomics Shared Resource.

PI_NAMEs: CAPRIOLI, RICHARD M (contact)

PROJECT_TERMS: Acetylation;Affinity Chromatography;assay development;Cancer Center;Cancer Center Support Grant;Chemicals;Collaborations;Communities;Complex;Complex Mixtures;Consultations;cost effective;crosslink;data acquisition;Data Analyses;Dedications;design;Deuterium;Dimensions;Doctor of Philosophy;Effectiveness;Elements;Ensure;experimental analysis;Experimental Designs;experimental study;Goals;High Pressure Liquid Chromatography;Histology;Hydrogen;Image;Individual;Inductively Coupled Plasma Mass Spectrometry;instrument;instrumentation;Isotope Labeling;Label;Laboratories;laboratory facility;Laboratory Personnel;large datasets;Leadership;Location;Malignant Neoplasms;Mass Fragmentography;mass spectrometric imaging;Mass Spectrum Analysis;medical schools;member;Mentorship;metabolomics;Methods;Mission;Modification;Molecular Profiling;multiple reaction monitoring;NCI Center for Cancer Research;new technology;novel strategies;Peptides;Pharmaceutical Preparations;Phosphorylation;Post Translational Modification Analysis;Post-Translational Protein Processing;Postdoctoral Fellow;Preparation;Procedures;programs;Protein Analysis;protein crosslink;protein expression;protein profiling;protein protein interaction;Proteins;Proteome;Proteomics;Proteomics Shared Resource;Reproducibility;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;responsible research conduct;Role;Sampling;service delivery;Services;skills;small molecule;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Stable Isotope Labeling;Students;System;Techniques;Technology;Tennessee;Tissue imaging;Tissues;tool;Training;Training and Education;Ubiquitination;Universities;Validation


NIH_SPENDING_CATS: Bioengineering;Cancer

PHR: CORE 004 – CELL IMAGING SHARED RESOURCE PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Cell Imaging Shared Resource.

PI_NAMEs: TYSKA, MATTHEW J (contact)

PROJECT_TERMS: Acceleration;anti-cancer research;Basic Science;Biomedical Engineering;Cancer Center;Cancer Center Support Grant;Caring;Cell Physiology;cellular imaging;Collaborations;Communities;Computers and Advanced Instrumentation;cost;Data;data acquisition;Data Analyses;Dedications;design;Development;digital imaging;Doctor of Philosophy;Effectiveness;Electron Microscope;Electron Microscopy;Ensure;Equipment;Experimental Designs;fluorescence microscope;Functional Imaging;Funding;Future;Goals;Human Resources;Image;imaging capabilities;Individual;Institution;Instruction;instrumentation;Leadership;Learning;Light;Lighting;live cell microscopy;Maintenance;Malignant Neoplasms;medical schools;member;Mentors;Mentorship;Methods;Microscope;Microscopic;microscopic imaging;Microscopy;Mission;Modeling;Modernization;NCI Center for Cancer Research;new technology;Optics;Outcomes Research;Philosophy;Physics;Preparation;Probability;programs;Publications;reconstruction;Reproducibility;Research;Research Methodology;Research Personnel;Research Support;Resource Sharing;Resources;Scanning;Services;skills;Source;Specimen;Speed;Strategic Planning;Structure;Students;Subcellular Anatomy;success;superresolution microscopy;Surveys;Techniques;Technology;Tennessee;Time;Tissues;Training;ultra high resolution;Universities;Update;Work

PROJECT_TITLE: Cell Imaging Shared Resource


PHR: CORE 005 – CHEMICAL SYNTHESIS AND HIGH-THROUGHPUT ANALYTICS SHARED RESOURCE PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Chemical Synthesis and High- Throughput Analytics Shared Resource.

PI_NAMEs: SULIKOWSKI, GARY ALLEN (contact)

PROJECT_TERMS: 3-Dimensional;Affinity;Animals;anti-cancer;anti-cancer research;Antineoplastic Agents;Area;assay development;Automation;Basic Cancer Research;Biochemical;Biological;Biological Assay;Biology;cancer cell;Cancer Center;Cancer Center Support Grant;Cells;chemical synthesis;Chemicals;Chemistry;Clinical;Collection;Communities;Complex;Custom;design;Development;Disease;drug action;Drug Combinations;drug discovery;Drug Kinetics;drug mechanism;drug metabolism;Drug resistance;Drug Targeting;Effectiveness;Ensure;Epigenetic Process;experience;Experimental Designs;FDA approved;Flow Cytometry;Fluorescent Probes;Formulation;functional genomics;Funding;Future;Genomic Library;Goals;high throughput screening;Human;human model;Image;Immunomodulators;Immunooncology;In Vitro;in vivo;Individual;Informatics;insight;Institution;instrument;instrumentation;interest;Investments;Isotope Labeling;kinase inhibitor;Kinetics;Lead;lead optimization;Leadership;Libraries;Malignant Neoplasms;Measures;medical schools;member;Mentorship;Methodology;Methods;model organism;Modeling;NCI Center for Cancer Research;new therapeutic target;novel;novel anticancer drug;novel therapeutic intervention;novel therapeutics;Nucleotides;Organoids;patch clamp;Pathway interactions;Patients;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phenotype;Play;pre-clinical;Pre-Clinical Model;programs;Property;Reproducibility;Research;Research Personnel;Research Support;Resistance;Resource Sharing;Resources;responsible research conduct;Role;Sampling;screening;screening services;Services;Small Interfering RNA;small molecule;Structure;Structure-Activity Relationship;Students;Techniques;Technology;Tennessee;Testing;three dimensional cell culture;tool;Training;Translating;translational cancer research;Translational Research;tumor;tumor metabolism;United States National Institutes of Health;Universities;validation studies;virtual;whole genome;Whole Organism;Work

PROJECT_TITLE: Chemical Synthesis and High-Throughput Analytics Shared Resource


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Data Science;Networking and Information Technology R&D (NITRD)

PHR: CORE 006 – DATA SCIENCE SHARED RESOURCE PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Data Science Shared Resource.

PI_NAMEs: SHYR, YU  (contact)

PROJECT_TERMS: Animals;Basic Science;Bioinformatics;bioinformatics pipeline;bioinformatics tool;Biological;biological research;Biometry;Biostatistics Shared Resource;Cancer Center;Cancer Center Support Grant;Clinical;clinical decision support;Clinical Research;Clinical Trials;Collaborations;collaborative approach;Computational Biology;Computer software;Custom;Data;data acquisition;Data Analyses;data de-identification;data quality;Data Science;Data Set;database design;Databases;design;Development;Education;Educational workshop;Effectiveness;electronic data capture system;Electronic Health Record;Emerging Technologies;Ensure;Experimental Designs;flexibility;genome sciences;Genomics;Goals;Health Insurance Portability and Accountability Act;Human Resources;Individual;Informatics;Information Retrieval;Information Storage;Infrastructure;Institutional Review Boards;Laboratories;Laboratory Research;Laboratory Study;large datasets;Leadership;Manuscripts;meetings;member;Mentors;Mentorship;Methodology;Methods;Mission;novel;Participant;patient population;Patients;Population;Prevention;Privacy;Process;Productivity;programs;Proteomics;Quality Control;Reporting;Reproducibility;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;responsible research conduct;Sample Size;Science;Services;software development;Specimen;Students;Techniques;tool development;Training;Translating;Visualization;Work;Writing

PROJECT_TITLE: Data Science Shared Resource


PHR: CORE 007 – FLOW CYTOMETRY SHARED RESOURCE PROJECT NARRATIVE Per the PAR-17-095 FOA, the project narrative is not applicable for the Flow Cytometry Shared Resource.

PI_NAMEs: HIEBERT, SCOTT W (contact)

PROJECT_TERMS: Aerosols;Antibodies;Bar Codes;base;Biological Assay;Cancer Center;Cancer Center Support Grant;catalyst;cell preparation;Cell Separation;Cells;Clinical stratification;Clinical Trials;Color;Complex;Computer software;Computers and Advanced Instrumentation;Containment;cost;cost effective;Custom;Cytometry;Data Analyses;Education;Elements;Ensure;Equipment;Experimental Designs;experimental study;Faculty;Flow Cytometry;Flow Cytometry Shared Resource;Funding;Future;genome sciences;Goals;Grant;Human Resources;Immune;immune cell infiltrate;Immunophenotyping;improved;Individual;Instruction;instrument;instrumentation;Lasers;Maintenance;Malignant Neoplasms;member;Methods;Mission;Modernization;multidisciplinary;NCI Center for Cancer Research;neoplastic cell;new technology;Performance;Phenotype;Preparation;Property;protocol development;Protocols documentation;Publications;Reproducibility;Research;Research Personnel;resource guides;Resource Sharing;Resources;Running;Sampling;Schedule;Services;single-cell RNA sequencing;skills;Sorting;Speed;Stains;stem;stem cell population;student training;success;Techniques;Time;Tissues;Training;Training and Education;tumor;Work

PROJECT_TITLE: Flow Cytometry Shared Resource