NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Digestive Diseases;Liver Disease;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Organ Transplantation;Transplantation

ORG_CITY: Houston

ORG_NAME: INFORMAI, INC.

PHR: PROJECT NARRATIVE The organ transplantation process has many inefficiencies and significant issues that result in less than optimal patient outcomes and impacts to valuable clinical resources. Our product, TransplantAI, aims to transform the organ matching process. By utilizing advanced AI algorithms, large proprietary datasets and access to world renowned medical experts at leading transplant centers and organ procurement organizations (OPOs), the InformAI team plans to address limitations of current transplant analytic models by enhancing data insights into organ discard, waitlist mortality and post transplant survival.

PI_NAMEs: HAVELKA, JIM  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Address;Anatomy;Architecture;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;automated segmentation;Classification;Clinical;clinical care;clinical decision support;cloud based;Code;Collaborations;college;Data;data access;data pipeline;Data Set;Decision Making;deep learning;design;Dimensions;Ensure;Environment;Evaluation;Exhibits;Face;Fast Healthcare Interoperability Resources;Funding;Future;Graft Survival;Health Care Costs;Health Insurance Portability and Accountability Act;Heart;Heart Rate;Heart Transplantation;hospital care;Hospitals;Human Subject Research;human-in-the-loop;Image;imaging Segmentation;improved;Informatics;innovation;insight;Institution;Institutional Review Boards;Journals;Kidney;Kidney Transplantation;Liver;liver transplantation;Lung;Lung Transplantation;Machine Learning;machine learning algorithm;machine learning method;machine learning model;machine learning pipeline;Manuals;Marketing;Measures;Medical;Medicine;meetings;Methodist Church;Methods;migration;Modeling;mortality;open source;Organ;organ allocation;Organ Donor;Organ Procurements;Organ Size;Organ Transplantation;Outcome;outcome prediction;Patient-Focused Outcomes;Patients;Peer Review;Performance;Phase;Physicians;point of care;portability;post-transplant;Process;prototype;Publishing;radiologist;Radiology Specialty;Research;Resources;Risk;Risk Assessment;Secure;Services;Site;Small Business Innovation Research Grant;Solid;success;Survival Rate;System;Techniques;Technology;Testing;Time;tool;Training;transplant centers;Transplant Recipients;transplant registry;Transplantation;Underrepresented Populations;United Network for Organ Sharing;United States National Institutes of Health;usability;user-friendly;verification and validation;Waiting Lists;wasting;web site;Work;X-Ray Computed Tomography

PROJECT_TITLE: Artificial Intelligence Tool to Optimize Organ Transplantation Outcomes (Transplant-AI)


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Neurosciences;Nutrition

ORG_CITY: DAVIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ZOOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative Modern human lifestyles powered by technological advances and demanding work schedules often impinge on robust daily rhythms of physiology and behavior, which are hallmarks of healthspan This project aims to understand the molecular mechanisms by which metabolic signals from feeding-fasting cycles interact with environmental time cues to orchestrate temporal changes in physiology. Our findings will shed light on the impact of disrupting metabolic regulation of daily rhythms and pave the way to new therapeutic targets for circadian and metabolic disorders.

PI_NAMEs: CHIU, JOANNA CHUNGYEN (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: Animal Model;Animals;Behavior;Behavioral;Biochemical;Biological Assay;Biological Rhythm;Biology;Biotin;blood-brain barrier permeabilization;Brain;Bypass;Cell Physiology;Cells;Chronic Disease;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;circadian transcriptome;Clock protein;Cues;Cysteine;Diet;Drosophila genus;Eating;Elements;Environment;enzyme activity;Equilibrium;Exhibits;Fasting;feeding;fly;Food;Future;Gene Expression;Genetic;Genetic Transcription;Goals;healthspan;High Fat Diet;Hour;Human;human disease;Immune System Diseases;insight;Knowledge;Life Style;Light;Link;lipid metabolism;lipidomics;Lipids;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Membrane;Metabolic;Metabolic Diseases;Metabolism;model organism;Modeling;Modernization;Modification;Molecular;Molecular Biology;molecular clock;mouse model;Mus;Nervous System Disorder;new therapeutic target;Nutrient;nutrition;Organ;Output;Palmitates;palmitoylation;Pathology;Periodicity;Peripheral;Phase;Phosphorylation;Physiological;Physiology;Play;Post-Translational Protein Processing;Process;programs;protein function;protein protein interaction;Proteins;Proteome;Proteomics;Publishing;receptor;Regulation;Regulatory Pathway;Reporting;response;Role;Saturated Fatty Acids;Schedule;Shapes;Signal Transduction;Site;Sleep Wake Cycle;sugar;Technology;Temperature;Testing;Time;Time-restricted feeding;Tissues;transcription factor;Western Blotting;Work

PROJECT_TITLE: Non-transcriptional regulation of circadian physiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-U (02)]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Deterioration of the retina, the light-sensing portion of the eye, is caused by a number of incurable inherited diseases that result in progressive vision loss and blindness. This proposal focuses on determining how mutations in the metabolic enzyme IMPDH1 cause dominant forms of inherited photoreceptor degeneration. We aim to determine the normal physiological role of IMPDH1 in photoreceptors, and how this is perturbed in blind patients with degenerative disease due to IMPDH1 mutations.

PI_NAMEs: BROCKERHOFF, SUSAN E (contact);KOLLMAN, JUSTIN M

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Adenine Nucleotides;Allosteric Regulation;Anabolism;Animals;Antibody Specificity;autosomal dominant mutation;Biochemical;Biochemistry;Biological;Biological Assay;Biological Models;blind;Blindness;Cell Physiology;cell type;Cells;Cellular biology;circadian;Collection;Cryoelectron Microscopy;Data;Degenerative Disorder;Deterioration;Disease;disease model;Dissection;DNA Binding;energy balance;Energy Metabolism;Engineering;enzyme activity;Enzyme Inhibition;Enzymes;Equilibrium;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Eye;Filament;gain of function;Genetic;Genetic Transcription;Genome;Guanine Nucleotides;Health;Hereditary Disease;Homeostasis;Human;human disease;Immunofluorescence Immunologic;Immunoprecipitation;In Situ;In Vitro;in vivo;Inherited;Inosine Monophosphate;interdisciplinary approach;Knock-out;Knockout Mice;Light;Link;Metabolic;Metabolism;Methods;Missense Mutation;Mitochondria;Mitochondrial DNA;Modeling;Molecular;mutant;Mutation;Nucleotide Biosynthesis;nucleotide metabolism;Nucleotides;Oxidoreductase;Pathway interactions;Patients;Phenotype;photoreceptor degeneration;Photoreceptors;Physiological;Polymers;Positioning Attribute;Property;protein expression;Proteins;purine metabolism;Purine Nucleotides;Purines;RalDH1;Reagent;Regulation;Reporter;Resolution;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;Retinal Dystrophy;RNA;Role;Signaling Molecule;Single-Stranded DNA;structural biology;Structure;Tissues;tool;Transgenic Organisms;Translations;Variant;Vertebrate Photoreceptors;Zebrafish

PROJECT_TITLE: IMPDH1 in photoreceptor function and disease

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Obesity;Osteoporosis;Prevention

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Bariatric surgery could provide considerable health benefit to the 30 million Americans living with severe obesity, but the associated risk of bone loss and fracture is concerning to both patients and providers. This ancillary study to an ongoing clinical trial is designed to test whether a first-line antiresorptive medication for osteoporosis can preserve bone microarchitecture, density, and strength in the year after bariatric surgery. This will improve our understanding of antiresorptive treatment efficacy in bariatric surgery patients, and offer insight on the underlying biological mechanisms of action for preventing bone microstructure deterioration, which is increasingly recognized as an independent predictor of fracture.

PI_NAMEs: WEAVER, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: 3-Dimensional;Address;Age;American;Ancillary Study;Area;Attenuated;Award;bariatric surgery;Beavers;bioimaging;Biological;Biological Markers;Biology;bisphosphonate;blood-based biomarker;Body fat;Body Weight decreased;bone;Bone Density;bone fragility;bone loss;bone preservation;Bone remodeling;Bone Resorption;bone strength;Bone Tissue;bone turnover;calcification;Clinical;clinical practice;Clinical Practice Guideline;Clinical Trials;cohort;comorbidity;cortical bone;cost effective;Data;density;design;Deterioration;Diameter;Distal;Dual-Energy X-Ray Absorptiometry;Elements;Enrollment;Ensure;Equipment;European;Failure;Femur;Finite Element Analysis;Fracture;Funding;Gastrectomy;Grant;Health Benefit;Hip region structure;Image;imaging modality;improved;in vivo imaging;Infrastructure;insight;Institution;Intervention;intervention effect;Knowledge;Low Dose Radiation;Measures;mechanical load;Metabolic;Modality;Monitor;Morbid Obesity;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Neck;novel;Obesity;Operative Surgical Procedures;Osteogenesis;Osteoporosis;Outcome;Parents;Participant;participant enrollment;Patients;Peripheral;Pharmaceutical Preparations;Placebos;Porosity;Positioning Attribute;preservation;prevent;primary outcome;prophylactic;prospective;Provider;Publishing;Radial;Randomized;randomized trial;Randomized, Controlled Trials;Regulation;Reproducibility;Resolution;Resources;response;Risedronate;Risk;Scanning;Secondary to;Secure;Site;skeletal;Societies;Structure;substantia spongiosa;Testing;Thick;tibia;Time;Tissues;Treatment Efficacy;Vertebral column;Visit;X-Ray Computed Tomography

PROJECT_TITLE: Adding bone microarchitecture and strength measures to the STRONG BONES randomized trial examining risedronate use to mitigate bone loss after bariatric surgery

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 SP (M1)]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Social Determinants of Health

ORG_CITY: GOLDEN

ORG_NAME: TDA RESEARCH, INC.

ORG_STATE: CO

PHR: Project Narrative Typical indoor air pollutants include CO, VOCs, nitrogen oxides, benzene, and formaldehyde. As people spend ~90% of their time indoors, the EPA considers indoor air pollution to be one of the top five environmental risks to public health (EPA 2019). Particularly important are chlorinated VOCs, which are known to increase the risk of cancer from 1 in a million to 1 in 100,000 at 4 ppb, typical concentrations observed in indoor air (WHO Guidelines for Indoor Air Quality: Selected Pollutants 2010). Our technology will reduce the high risk VOCs and other common pollutants to less than 4 ppb to reduce health risks.

PI_NAMEs: JAYARAMAN, AMBALAVANAN  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: 3-Dimensional;Adsorption;Air;Aircraft;Benzene;Breathing;building materials;cancer risk;Carbon;Carbon Dioxide;Carbon Monoxide;catalyst;Certification;Cessation of life;Chemicals;cigarette smoke;Collaborations;commercialization;cooking;Dangerousness;Data;Dedications;design;Devices;Drops;Economics;Electronics;Engineering;Environment;Environmental Risk Factor;Evaluation;Excision;experience;fabrication;Filtration;Formaldehyde;Formulation;Furniture;Gases;Government;Guidelines;Health;high efficiency particulate air filter;high risk;Home;Household;Incidence;indoor air;Indoor Air Pollution;Indoor Air Quality;indoor concentrations;indoor exposure;indoor pollutant;Industry;Inhalation;irritation;Life;Malignant Neoplasms;manufacture;manufacturing facility;Marketing;Metals;Modification;National Institute of Environmental Health Sciences;neurotoxic;Nitrogen Dioxide;Nitrogen Oxides;operation;oxidation;particle;Particulate;Performance;Persons;Phase;pollutant;Pollution;portability;Preparation;pressure;prototype;Public Health;Pump;Recommendation;Recycling;Research;Risk;Schools;Small Business Innovation Research Grant;Source;Spacecraft;System;Systems Integration;Techniques;Technology;Temperature;Testing;Time;toxicant;Toxin;volatile organic compound;water vapor;Weight;Workplace

PROJECT_TITLE: High Efficiency Sorption System for Removing Harmful Contaminants from Indoor Air

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-S (12)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Disability Research;Hearing Loss;Neurosciences;Rehabilitation

ORG_CITY: OAKLAND

ORG_NAME: AURICLE HEALTH INC

PHR: Project Narrative High-frequency sensorineural hearing loss (SNHL) with residual low-frequency hearing impairs patients’ ability to understand speech, afflicts more than 3.3 million Americans, and annually costs more than $100B between health care and lost productivity. Current treatments are inadequate and destructive, leading to loss of residual hearing, but extracochlear stimulation of the spiral ganglion promises a minimally invasive method to restore speech understanding in affected individuals. In the proposed project, Auricle will iterate the design of its stimulation electrode and conduct an animal study to confirm long-term effectiveness of the implant, delivering proof-of-concept for its innovative strategy.

PI_NAMEs: WONG, FRANCIS  (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Acute;Adhesions;Adhesives;Adult;Affect;Age;aged;Algorithms;American;Animal Model;Animals;Auditory;Auditory Brainstem Responses;Back;Biological;biomaterial compatibility;bone;Cadaver;Cavia;Chronic;Clinical;Clinical Research;Cochlea;Cochlear Implants;Cochlear Nerve;cost;deaf;Dementia;design;Development;Device Designs;Devices;Discrimination;Effectiveness;electric impedance;Electrodes;energy efficiency;Exhibits;experimental study;external ear auricle;flexibility;Foundations;Frequencies;Frustration;Glass Ionomer Cements;Goals;Health;Healthcare;Hearing;Hearing Aids;hearing impairment;hearing restoration;High-Frequency Hearing Loss;Histologic;Human;Implant;Implanted Electrodes;improved;in vivo;Individual;Inflammatory;innovation;insight;Link;Measures;Mental Depression;Methods;middle ear;minimally invasive;Modeling;Monitor;neural stimulation;Neurons;novel;Operative Surgical Procedures;osteogenic;Otology;Patients;Persons;Phase;Population;pre-clinical;preservation;Procedures;Process;Productivity;programs;Promontory;prototype;Public Health;Quality of life;Research;Residual state;response;Risk;Safety;Sampling;Sensorineural Hearing Loss;Silicones;social;Solid;sound;Speech;speech processing;spiral ganglion;Surface;Technology;Testing;Time;tissue preparation;Tissues;tool;Withdrawal;Work

PROJECT_TITLE: Development of an Extracochlear Device to Restore Hearing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-M (12)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Lung;Pediatric;Prevention

ORG_CITY: PALOS VERDES ESTATES

ORG_NAME: INDELIBLE LEARNING, INC.

PHR: PROJECT NARRATIVE Proper hand hygiene is a low-cost, high-impact intervention that can prevent transmission of a host of respiratory and gastrointestinal diseases (including the common cold, Influenza, Norovirus, Shigella, and others); our interactive handwashing trainer improves hand washing technique, decreases the amount of germs on hands, and addresses an urgent unmet public health need to blunt the spread of infections.

PI_NAMEs: CRILEY, JASMINKA  (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: 3-Dimensional;Absenteeism at work;Achievement;Address;Adherence;Adult;Age;Anatomy;animation;Area;Awareness;Behavior;Businesses;care costs;Caring;Cellular Phone;Cessation of life;Child;Childhood;Clinics and Hospitals;Code;commercialization;Common Cold;Communities;Computers;cost;cost effective intervention;COVID-19;dashboard;Decision Making;design;design,build,test;Development;Devices;digital;Disease;Disease Outbreaks;economic impact;Education;Educational process of instructing;effectiveness evaluation;efficacy study;Ensure;Evaluation;experience;falls;Family;feasibility testing;flu;Fluorescent Dyes;Focus Groups;Fostering;gastrointestinal;Gastrointestinal Diseases;gastrointestinal infection;General Population;Germ;Habits;Hand;Handwashing;Health Benefit;Hospitalization;Hygiene;Image;improved;Infection;infection risk;Influenza;innovation;Instruction;Intervention;Intuition;Learning;Lighting;Measures;member;memory consolidation;Methods;Microbiology;Motion;Norovirus;Nose;novel;Oral cavity;oral infection;Outcome;pandemic disease;Parents;pathogen;Patients;Performance;performance site;Persons;Phase;Play;Positioning Attribute;prevent;Production;Productivity;productivity loss;programs;prototype;Public Health;Randomized, Controlled Trials;Recommendation;Regimen;Reporting;Research Design;Research Personnel;research study;respiratory;Respiratory Disease;Respiratory Syncytial Virus Infections;Respiratory Tract Infections;Rewards;Running;School Nursing;School Teachers;School-Age Population;Schools;Seasons;Shigella;Site;skills;Soaps;student participation;Students;success;Supervision;Surface;System;Tablets;teacher;Teaching Materials;Techniques;Technology;Testing;Time;tool;Touch sensation;touchscreen;Training;transmission process;trend;usability;virtual;visual feedback;Work;World Health Organization

PROJECT_TITLE: Interactive Hand Hygiene Trainer for School-Age Children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (10)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: Spokane

ORG_NAME: PHOTON BIOSCIENCES, LLC

PHR: Project Narrative No dual modality probe of the type that is required for super-resolution correlated light electron microscopy (CLEM) is readily available. To enable elucidation of cellular and detailed subcellular structures at the pseudoatomic level using super-resolution CLEM, Photon Biosciences proposes a novel genetically expressible probe that has high electron density and luminescence necessary to act as a dual-modality probe for both modes of imaging. This novel and innovative probe for super-resolution CLEM will enable biomedical innovations that require modeling regions of interest inside a cell to a pseudoatomic level.

PI_NAMEs: LAWRENCE, CHARLES MARTIN;LEWIS, KEVIN MICHAEL (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;base;Binding;Binding Sites;Biological Sciences;Cell Physiology;Cells;Chimeric Proteins;clinical diagnostics;Clustered Regularly Interspaced Short Palindromic Repeats;commercialization;Complex;Coupled;cryogenics;electron density;Electron Microscopy;electron tomography;Electrons;Engineering;Environment;Fluorescent Probes;fusion gene;Genes;genome editing;Genome engineering;Goals;Gold;Image;in silico;innovation;interest;Ions;Lanthanoid Series Elements;Light;light microscopy;luminescence;Metallothionein;Microscope;microscopic imaging;Microscopy;Modality;Modeling;Monitor;Mutate;nanoscale;Nature;Noise;novel;Nuclear;overexpression;Parents;Peptides;Phase;phosphorescence;Photons;Plasmids;polypeptide;Proteins;Pseudomonas aeruginosa;quantum;Quantum Dots;Research;Resolution;Ribosomal Proteins;Ribosomes;Shapes;Signal Transduction;single molecule;small molecule;Structure;Subcellular structure;success;superresolution microscopy;Techniques;Temperature;Time;Tomogram;tomography;tool;ultra high resolution;Validation;Variant;Visualization

PROJECT_TITLE: A Biosinpired Genetically-Expressible Dual-Modality Peptide-Based Probe for Super-Resolution Correlative Light and Electron Microscopy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-G (15)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD)

ORG_CITY: LADERA RANCH

ORG_NAME: MYRIAD ADVANCED TECHNOLOGIES LLC

PHR: Project Narrative In the United States, eye surgeries are the most frequently performed surgical interventions aimed at mitigating the adverse effects of vision loss that can significantly impact the quality of life of individuals and their families, and pose serious safety risks, necessitating long-term care. Effective ophthalmic intraoperative visualization is crucial for achieving favorable surgical outcomes in the treatment of eye diseases. To enhance visualization and consequently improve surgical outcomes, we are developing a System on Chip to enable Swept-Source Optical Coherence Tomography to provide real-time 3- dimensional imaging with high-resolution, high-speed, low-latency, and the capacity to handle large volume scans.

PI_NAMEs: AL-QAISI, MUHAMMAD  (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: 3-Dimensional;Adoption;Adverse effects;Algorithms;analog;Apple;Architecture;Artificial Intelligence;Blindness;Businesses;California;ChIP-on-chip;Clinic;Clinical;Communication;cost;Custom;Data;design;Development;digital;Digital Signal Processing;Electronics;Evaluation;Eye diseases;Family;Generations;Goals;Hand;Healthcare;high volume manufacturing;Hybrids;Image;Image Analysis;Imaging technology;improved;Individual;integrated circuit;Lasers;Logic;Long-Term Care;Marketing;meter;Microscopy;Modernization;Monitor;next generation;novel;novel strategies;open source;Operating Rooms;Operative Surgical Procedures;Ophthalmologic Surgical Procedures;Optical Coherence Tomography;Optics;Performance;Persons;Phase;Process;Protocols documentation;prototype;Pythons;Quality of life;Radio communications;radio frequency;Readiness;reconstruction;research and development;Resolution;Resources;Risk;Safety;Sampling;Scanning;Scientist;signal processing;Signal Transduction;Source;Speed;Stream;Structure;surgery outcome;System;Technology;Thick;Time;Tissues;Translating;United States;Vendor;virtual;Vision;Visualization;wireless communication;Work

PROJECT_TITLE: System on Chip for Intraoperative OCT

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-S (11)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: HONOLULU

ORG_NAME: HAWAII BIOTECH, INC.

ORG_STATE: HI

PHR: 8. Project Narrative The proposed research focuses on the further advancement of a candidate vaccine that protects against chikungunya virus (CHIKV) which causes debilitating disease in humans. The vaccine is based on an established recombinant subunit platform for producing viral envelope proteins. Although CHIKV is not yet prevalent in the U.S., recent epidemics in the Americas provide the potential for the virus to become endemic in the U.S. and its territories. CHIKV is classified as a category C priority pathogen and has been identified as a prototype pathogen for the Togaviridae family of viruses in NIAID’s Pandemic Preparedness Plan. A successful CHIKV vaccine would also streamline the rapid development of vaccines for other Togaviruses with pandemic potential.

PI_NAMEs: CLEMENTS, DAVID E (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acute Disease;Adjuvant;adverse event risk;Aedes;Alpha Virus;Americas;Antibodies;Area;Arthralgia;Arthritis;Attenuated;Biotechnology;Bite;Category C pathogen;Cells;Cessation of life;chikungunya;chikungunya infection;Chikungunya virus;Chronic;Chronic Disease;Classification;climate change;Clinical;Clinical Trials;Collaborations;college;combat;commercialization;Complex;Culicidae;Cyclic GMP;debilitating symptom;Dengue Virus;design;Development;Disease;Disease Outbreaks;Dose;emerging virus;Ensure;Epidemic;Epidemiology;Evaluation;Exanthema;experience;Family;Feedback;Fever;Flaviviridae;Formulation;Geographic Distribution;global health;Goals;Grant;Hawaii;Headache;Healthcare;Human;Human papillomavirus 16 E1 protein;Immune response;Immune Sera;Immunization;Immunocompetent;Immunocompromised Host;in vivo;Individual;Infection;innovation;Insecta;International;Licensing;Link;manufacture;Measures;Medicine;member;Methods;Morbidity - disease rate;mosquito-borne;mouse model;Mus;Myalgia;National Institute of Allergy and Infectious Disease;neutralizing antibody;next generation;Oryctolagus cuniculus;pandemic potential;pandemic preparedness;pathogen;Persons;Phase;Photophobia;Positioning Attribute;pre-clinical;preclinical development;prevent;Preventive;prototype;Published Comment;Quality of life;Readiness;Recombinant Proteins;recombinant virus;Recombinants;Reporting;Research;research clinical testing;Risk;Role;Safety;Serum;Severity of illness;Specific qualifier value;Subunit Vaccines;success;Symptoms;System;Tanzania;Technology;technology platform;Testing;Therapeutic;Togaviridae;Toxicology;transmission process;Vaccine Antigen;vaccine candidate;Vaccine Design;vaccine development;vaccine formulation;Vaccines;Viral;Viral Antigens;Viral Envelope Proteins;viral transmission;Virus;virus classification;Virus Diseases;Virus Replication;Virus-like particle;West Nile virus;Work

PROJECT_TITLE: Chikungunya Recombinant Subunit Vaccine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-D (10)]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Neurosciences;Regenerative Medicine;Transplantation

ORG_CITY: COLUMBIA

ORG_NAME: CRYOCRATE, LLC

ORG_STATE: MO

PHR: NARRATIVE The long-term vision of CryoCrate LLC related to this project is to commercialize a “First-in-Class” biocompatible cryopreservation medium product, OdinSol®, which eliminates the need for any toxic cell permeating cryoprotectant used in traditional cryopreservation methods. This novel technology will provide enabling and efficient options for biobanking urgently needed for the development and implementation of cell-based therapeutics and tissue engineering in personalized medicine and other emerging biomedical technologies. In this project, we will obtain qualifications associated with Good Manufacturing Practice production, biocompatibility, safety and efficacy testing, and secure 510(k) clearance, to pave the path to commercialization.

PI_NAMEs: HAN, XU  (contact)

PROGRAM_OFFICER_NAME: VONKOLLMAR, DESIREE

PROJECT_TERMS: 3-Dimensional;Age related macular degeneration;Apoptosis;Award;biobank;biomaterial compatibility;Biomedical Technology;bioprinting;Cell Physiology;Cell Therapy;Cells;Cellular Morphology;Chemicals;Cities;Clinical;Collaborations;commercial prototype;commercialization;Contracts;Cryopreservation;cytotoxicity;Data Set;Development;Devices;Dimethyl Sulfoxide;drug discovery;Drug Screening;Dry Ice;efficacy evaluation;efficacy testing;Endotoxins;Equipment and supply inventories;Evaluation;evaluation/testing;experience;extracellular;Feedback;Foundations;Future;Glycerol;Glycols;Goals;Good Manufacturing Process;Health;human induced pluripotent stem cells;Ice;immunodeficiency;Impairment;improved;In Vitro;in vivo;in vivo evaluation;induced pluripotent stem cell;Industry;Kansas;Laboratories;Letters;Liquid substance;Mammalian Cell;manufacturing organization;Marketing;Methods;Missouri;Modeling;Molecular;nanoscale;Nature;nerve stem cell;neural;neurophysiology;new technology;next generation;Nitrogen;novel;Osmolar Concentration;Outcome;personalized medicine;Pharmaceutical Preparations;pharmacologic;Polysaccharides;Practice Guidelines;preservation;prevent;Process;Production;Protocols documentation;Qualifying;Rattus;Reagent;regeneration model;regenerative;Regenerative Medicine;Research;Research Contracts;response;Safety;safety testing;Secure;Small Business Innovation Research Grant;Standardization;stem cell derived tissues;Sterility;Structure;Structure of retinal pigment epithelium;supply chain;Technology;technology platform;Testing;Tissue Differentiation;Tissue Donors;Tissue Engineering;Tissue Transplantation;Tissues;Trademark;Transplantation;Transplantation Surgery;Transportation;United States National Institutes of Health;Universities;Viscosity;Vision research;Work

PROJECT_TITLE: Establishment of a First-in-Class Biocompatible and Efficient Cryopreservation Technology Platform for the Next Generation of Cell-Based Therapeutics in Regenerative Medicine and Drug Discovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-G (13)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Organ Transplantation;Prevention;Substance Misuse;Transplantation

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE  Fifty percent of alcoholic liver disease (ALD) patients have alcohol recidivism within the first five years of transplantation, and advanced fibrosis or graft loss occurs in approximately 20% of those patients. We have found that the ceramide synthesizing enzyme ceramide synthase 6 is upregulated early in ALD at the stage of steatosis and regulates the development of fatty liver. This project aims to understand how CerS6 specifically regulates proteins involved in liver fat development and how CerS6 and its ceramides can be used as early biomarkers of ALD in patients with both pre- and post-transplant ALD.

PI_NAMEs: CARR, ROTONYA M (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Ablation;alcohol effect;alcohol prevention;Alcoholic Liver Diseases;Alcoholic steatohepatitis;Alcohols;Biochemical;Biogenesis;Biological Assay;Biological Markers;Biological Models;Biology;blood glucose regulation;Cells;Ceramides;Chronic;Cirrhosis;Closure by clamp;Complex;Data;Development;diagnostic biomarker;Diet;dihydroceramide desaturase;Disease;disorder control;early detection biomarkers;Early Diagnosis;Early identification;Energy Metabolism;Enzymes;Epidemiology;Ethanol;euglycemia;Experimental Models;Fatty acid glycerol esters;Fatty Liver;Fibrosis;Flow Cytometry;Genetic;Genetic Transcription;Genetically Engineered Mouse;global run on sequencing;glucose disposal;Glucose Intolerance;glucose tolerance;Goals;Grant;Hepatic;hepatic gluconeogenesis;Hepatocyte;Hepatology;Homeostasis;Human;Hyperinsulinism;Impairment;improved;In Vitro;in vivo;in vivo Model;Insulin Resistance;insulin sensitivity;insulin signaling;Investigation;Kinetics;Knockout Mice;Lesion;Lipase;lipidomics;Lipids;Liver;Liver diseases;liver transplantation;Longitudinal cohort;LoxP-flanked allele;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolic Pathway;metabolic phenotype;Modeling;Molecular;Mus;novel;Null Lymphocytes;Pathway interactions;Patients;perilipin;pharmacologic;Physiological;Physiology;post-transplant;post-transplant disease;prevent;Prevention;problem drinker;Protein Biosynthesis;Proteins;recidivism;Recurrence;Recurrent disease;reduced food intake;Regulation;Research;Research Personnel;Role;Serodiagnoses;Serum;Signal Transduction;skills;Sphingolipids;Steatohepatitis;synthetic enzyme;Testing;Therapeutic;therapeutic biomarker;Tissues;Tracer;transcription factor;Transcriptional Regulation;transcriptome sequencing;Translating;Transplant Recipients;Transplantation;Triglycerides;United States;Up-Regulation;Weight Gain;Work

PROJECT_TITLE: Molecular mechanisms of post-transplant recurrent alcoholic liver disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(03)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: ATLANTA

ORG_DEPT: NEUROLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Motor symptoms of Parkinson’s disease remain a major disability for a large number of patients over the chronic course of the disease because currently available treatments provide only partial improvement. This project investigates a novel therapeutic strategy to selectively target genes in affected brain areas. Results of these preclinical studies can lead to clinical tests of a new gene therapy to improve mobility in patients with Parkinson’s disease.

PI_NAMEs: PAPA, STELLA M (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Affect;Animal Model;Area;Attention;Behavior;Behavioral;Bilateral;Binding Sites;Brain;Brain region;Cell membrane;Cells;Chronic;Clinical;Clinical Trials;Cognitive;cognitive change;Cognitive deficits;cognitive testing;Corpus striatum structure;Data;Development;disability;Disease;disease model;Disease Progression;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;Dose;drug action;Dyskinetic syndrome;efficacy evaluation;Electrophysiology (science);Evaluation;Evolution;Functional disorder;functional restoration;Gene Expression;Gene Silencing;gene therapy;gene-targeted therapy;Genes;Genetic;glutamatergic signaling;Glutamates;Grant;Health;Hyperactivity;Impaired cognition;improved;improved mobility;in vivo;inhibitor;Injections;knock-down;Learning;Levodopa;Measures;Memory;Midbrain structure;Modeling;Morphology;Motor;motor deficit;Motor disability;motor disorder;motor impairment;motor symptom;Movement;MPTP model;MPTP non-human primate;MPTP Poisoning;Neurobehavioral Manifestations;Neurons;nigrostriatal degeneration;nonhuman primate;novel;novel therapeutic intervention;optogenetics;Outcome Measure;Parkinson Disease;Parkinsonian Disorders;parkinsonian non-human primate;Pathologic;Patients;Performance;Periodicals;Pharmacotherapy;Phenotype;Physiological;Play;preclinical study;Primates;promoter;Rattus;Recombinant adeno-associated virus (rAAV);Regulation;Research;Resolution;response;Rodent;Role;Safety;safety assessment;Signal Transduction;small hairpin RNA;Standard Model;Structure;Synapses;synaptic function;Testing;Therapeutic Effect;therapeutic target;tool;translational study;Up-Regulation;vector;Viral Vector;Virus

PROJECT_TITLE: Gene therapy targeting striatal dysfunction for Parkinson’s disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: GALVESTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Drug overdose deaths, misuse and substance use disorders (SUDs) collectively constitute a major, high-impact health problem in the U.S. This competitive renewal of the training grant Translational Explorations in Substance Use Disorders (T32 DA007287) at the University of Texas Medical Branch addresses the large gap between the problem of SUDs and efficacious solutions by applying innovative mentoring and research approaches to fully equipping the next generation of SUD scientists to greatly enhance therapeutic strategies.

PI_NAMEs: CUNNINGHAM, KATHRYN A. (contact);HOMMEL, JONATHAN DEAN

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Substance Use Disorder


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: This project is focused on the impact of the COVID-19 pandemic on pain management for Veterans with chronic low back pain. Chronic low back pain is the most common form of chronic pain for Veterans, causing significant pain and disability. Current recommendations from experts are that Veterans receive several forms of pain management services, with an emphasis on approaches other than opioid medications. The COVID-19 pandemic may have led to substantial disruptions and changes in pain management services, including increases in telehealth. This mixed-methods project will explore changes in pain management services following the onset of COVID-19, including any persisting effects, and perceived impacts of these changes (negative and positive). Finally, the project includes a stakeholder panel comprised of operational partners, Veterans, clinicians, and other experts who will provide guidance throughout the research and ensure rapid dissemination of findings and recommendations.

PI_NAMEs: MATTHIAS, MARIANNE S;MCGUIRE, ALAN BENJAMIN (contact)

PROJECT_TERMS: Address;Administrator;Affect;Appointment;Area;care delivery;Caring;Characteristics;chiropracty;Chronic Care;Chronic low back pain;chronic pain;chronic pain management;chronic painful condition;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Collection;data warehouse;design;Diagnosis;disability;effective therapy;Ensure;Environment;Equity;Event;evidence base;experience;Funding;Future;Goals;Guidelines;health care delivery;Health Services Accessibility;Healthcare;Height;implementation strategy;innovation;interest;Interruption;Interview;Light;Low Back Pain;Methodology;Methods;Modality;multimodality;Nonpharmacologic Therapy;Office Management;Opioid;Opioid Analgesics;opioid epidemic;opioid use disorder;Outcome;Pain;Pain management;pandemic disease;Participant;Patients;Pattern;Persons;Pharmaceutical Preparations;Phase;Physical therapy;Policies;post-COVID-19;prescription opioid;public health emergency;Publishing;Race;Recommendation;Reporting;Research;response;Retrospective cohort;Safety;Sampling;satisfaction;service delivery;Services;Site;Surveys;telehealth;Telephone;Testing;Time;Veterans;virtual delivery;virtual healthcare;virtual visit;Visit;Work

PROJECT_TITLE: COVID-19 Impact on Pain management: Highlighting, Explaining, and Realigning services (CIPHER)

STUDY_SECTION_NAME: Special Emphasis Panel[HSR9]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome;Nutrition

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE The microbiota protects the host from microorganisms that cause disease in unprotected or immunocompromised individuals. Enteric pathogens such as Salmonella enterica, however, are adept at circumventing and weakening these protections and in doing so render the host susceptible to infection. Here, we propose to elucidate the mechanisms by which Salmonella overcomes microbiota-mediated colonization resistance with the goal of uncovering new therapeutic strategies to restore this important protective barrier.

PI_NAMEs: RADLINSKI, LAUREN CHRISTINE (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: acid stress;Acids;Amino Acids;Animal Model;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Attenuated;bacterial genetics;Biochemical Reaction;biological adaptation to stress;Buffers;Carboxy-Lyases;Catabolism;Cataloging;Cell Death;colonization resistance;commensal microbes;Communities;Consumption;Cytoplasm;Cytosol;Dietary Fiber;Discipline;Disease;dysbiosis;Ecosystem;Engineering;enteric infection;enteric pathogen;Enterobacteriaceae;Environment;Family;Fermentation;gastrointestinal;gastrointestinal infection;Glean;Gnotobiotic;Goals;Growth;gut colonization;gut homeostasis;high risk;Homeostasis;Host Defense;Hypoxia;Immunocompromised Host;improved;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory Response;innovation;intestinal epithelium;Intestines;Invaded;Knowledge;Large Intestine;Link;Mediating;Metabolic Pathway;metabolomics;Microbe;microbial;microbial community;microbiome;microbiota;microbiota composition;microorganism;Modeling;Modification;mouse model;Mus;novel therapeutic intervention;Nutrient;Nutritional;Outcome;pathogen;Pathway interactions;Patients;pH Homeostasis;Play;Predisposition;prevent;Production;programs;Protons;Public Health;Reaction;Research;Resistance;Role;Salmonella;Salmonella enterica;Salmonella infections;Salmonella typhimurium;Secure;Supplementation;Testing;Toxic effect;Treatment Failure;Type III Secretion System Pathway;Virulence;Virulence Factors;Volatile Fatty Acids;Work

PROJECT_TITLE: Mechanisms of Microbial Competition During Salmonella Infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07B-U(20)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Black individuals are burdened by a constellation of socioeconomic and cardiovascular risk factors that put them at a greater risk for developing Alzheimer's disease and related dementias (ADRDs). One potential explanation for the increased burden of these factors and overall risk for ADRDs is racially stratified educational environments and resulting experiences of discrimination, yet there is little evidence on the potential lifecourse effects of structural and interpersonal racism as a driver of racial inequalities in healthy brain aging. This study will use rigorous casual inference methods to provide new evidence on how school segregation and experiences of discrimination impact ADRDs risk and contribute to racial disparities.

PI_NAMEs: GUTIERREZ, SIRENA CELESTE (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Address;Adult;Affect;African American population;Age;Aging;aging brain;Alzheimer's disease related dementia;Alzheimer's disease risk;biological adaptation to stress;Black Populations;Black race;brain health;cardiovascular risk factor;career;Chronic;Cognitive;Cognitive aging;cognitive function;cohort;Competence;Dementia;dementia burden;dementia risk;Desegregation;Discrimination;Disparity;early childhood;Education;educational atmosphere;Employment Opportunities;Environment;Epidemiologic Methods;Epidemiologist;Ethnic Population;Event;experience;Exposure to;first grade;Funding;Future;Goals;Health;health care availability;health inequalities;healthy aging;high risk;human old age (65+);Hypertension;Impaired cognition;improved;Income;Individual;Inequity;insight;Intervention;late life;Life;Life Cycle Stages;Life Experience;Link;Longitudinal cohort;Measures;Mediator;Mentorship;Methodology;Methods;middle age;mild cognitive impairment;Neighborhoods;ninth grade;Not Hispanic or Latino;Occupational;older adult;Outcome;Participant;Pathway interactions;Patient Self-Report;perceived discrimination;Physiological;Policies;poor health outcome;Population;Population Heterogeneity;Population Intervention;prevent;Public Health;Race;racial difference;racial disparity;racial population;Racial Segregation;racism;Records;Research;Research Personnel;Research Support;residential segregation;Risk;Risk Factors;Role;school environment;Schools;Scientist;segregation;Shapes;sixth grade;skills;Social Environment;social factors;Socioeconomic Status;socioeconomics;stressor;Structural Racism;System;Time;Training;twelfth grade;United States;Work

PROJECT_TITLE: Racial Disparities in Alzheimer's Disease and Related Dementias: The Role of School Segregation and Experiences of Discrimination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-D(20)L]


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Microglia and macrophages assume diverse functional states after ischemic stroke and critically influence neuroinflammation, injury progression, and brain repair. This proposal will investigate the role of signal transducer and activator of transcription 1 (STAT1) in regulating microglial and macrophage functions and long- term stroke outcomes, and the underlying mechanisms involving inflammation resolution and neurorestoration. Positive results from this proposal may also pave the road for the potential clinical use of STAT1 inhibitor as a therapy to enhance rehabilitation and recovery, and improve the quality of life of stroke victims.

PI_NAMEs: SHI, YEJIE  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;Affect;arginase;Brain;Brain Infarction;Brain Injuries;brain remodeling;brain repair;brain tissue;Cells;Cerebral Ischemia;Cerebrum;Clinical;clinical translation;Clinical Treatment;clinically relevant;Coculture Techniques;Cognitive deficits;Cues;effective therapy;Equilibrium;fludarabine;Foundations;Functional disorder;Future;gene repair;Genes;Genetic;gray matter;Guidelines;Homeostasis;Hour;Immune;immune function;Immune response;improved;In Vitro;in vitro testing;in vivo;in vivo evaluation;Infiltration;Inflammation;Inflammatory;inhibitor;Injury;Interferons;intraperitoneal;Invaded;Ischemia;Ischemic Stroke;knock-down;Knock-out;Lentivirus;long term recovery;Macrophage;Mediator;Microglia;Middle Cerebral Artery Occlusion;Modeling;Molecular;monocyte;Mus;Nature;Nervous System Physiology;neuroinflammation;neurological recovery;neuron loss;Neurons;neuroprotection;neurorestoration;new therapeutic target;novel;old mice;Outcome;overexpression;Peripheral;pharmacologic;Phenotype;Phosphorylation;Pilot Projects;post stroke;preservation;prevent;primary endpoint;Quality of life;Recovery;Recovery of Function;Rehabilitation therapy;repaired;Resolution;response;Role;sex;Signal Induction;Signal Transduction;small hairpin RNA;Solid;STAT1 protein;Stroke;stroke outcome;stroke recovery;stroke therapy;stroke victims;Tamoxifen;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Time;Titrations;transcription factor;Transgenic Organisms;Treatment Protocols;white matter;Work;young adult

PROJECT_TITLE: Modulating microglia and macrophage functions to promote stroke recovery

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Eczema / Atopic Dermatitis;Immunotherapy;Infectious Diseases;Microbiome;Pediatric

ORG_CITY: LA JOLLA

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative  This project seeks to establish an ADRN Clinical Research Center that will advance understanding of Atopic Dermatitis. The successful completion of our aims will provide essential new information to permit development of an innovative therapy based on the topical use of naturally occurring beneficial skin bacteria.

PI_NAMEs: GALLO, RICHARD L (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: 18 year old;6 year old;Adult;Age;Anti-Inflammatory Agents;Antibiotic Resistance;Antibiotics;Antigen-Presenting Cells;antimicrobial;Atopic Dermatitis;Bacteria;beneficial microorganism;Cells;Characteristics;Child;Childhood;Chronic;Chronic Disease;Clinical Research;cohort;Cutaneous;Defect;Dermal;Dermis;Development;Disease;Dose;dysbiosis;Elements;Environment;Epithelial Cells;fighting;Frequencies;Functional disorder;Goals;Growth;Human;Immune response;Immune system;Immune Targeting;Immunosuppression;Immunosuppressive Agents;Immunotherapy;improved;Incidence;Inflammation;Inflammatory;innovation;Innovative Therapy;insight;Interruption;Intervention;keratinocyte;Lymphocyte;mast cell;Measures;member;Microbe;microbial;microbiome;microbiome therapeutics;Mission;Mupirocin;Myelogenous;Nature;novel therapeutic intervention;Oral;Patients;pediatric patients;Penetration;Peptide Hydrolases;Peptides;Phenotype;Play;Population;prototype;Recurrence;Research;response;Severities;Shapes;side effect;Skin;skin barrier;skin disorder;skin microbiome;Staphylococcus aureus;Staphylococcus hominis;success;Surface;Testing;Topical Antibiotic;Topical application;Toxin;Triamcinolone;Work

PROJECT_TITLE: Microbiome Function in Atopic Dermatitis


ADMINISTERING_IC: HD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative  Cells lining the lower part of the oviduct retain sperm to form a reservoir before fertilization. The goal of this study is to define how complex sugars on the sperm surface and newly-discovered Siglec proteins in the reservoir surface contribute to sperm adhesion and regulation of the local immune system. The long-term outcome of our findings could result in the development of novel contraceptive targets and help us understand some of the causes of idiopathic infertility.

PI_NAMEs: MOLINA, LEONARDO  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Address;Adhesions;Affinity;Binding;Biochemical;Biological;Biological Assay;career;career development;Cell Line;cell type;Cells;Chemotaxis;Complex;Contraceptive methods;contraceptive target;Data;data management;Deposition;Development;Diagnosis;Educational workshop;Embryonic Development;Environment;Epithelial Cells;Epithelium;experience;experimental study;Faculty;Family suidae;female reproductive tract;Fertility;Fertilization;gamete transport;Gene Expression;Genomic approach;Germ Cells;Glycobiology;Glycoconjugates;Glycolipids;Goals;Grant;Hamsters;Hour;idiopathic infertility;Illinois;Immune;Immune response;Immune system;Immunohistochemistry;Immunology;immunoregulation;Immunosuppression;In Vitro;in vivo;in vivo Model;Infiltration;Innate Immune Response;innovation;Insemination;insight;interdisciplinary approach;Knock-out;Knowledge;Learning;Lectin;Leucocytic infiltrate;Leukocyte Chemotaxis;life span;Ligands;Location;male;Mammalian Oviducts;Mammals;Mass Spectrum Analysis;Measures;Mediating;Mediator;Mentors;Migration Assay;Modeling;Molecular;Neuraminidase;novel;novel strategies;Organ;Outcome;Phagocytes;Polysaccharides;practical application;prevent;professor;programs;Proteins;Rattus;receptor;Regulation;Reproduction;Reproductive Biology;Research;Research Training;Resources;response;responsible research conduct;Role;Science;Scientist;senior faculty;sialic acid binding Ig-like lectin;Sialic Acids;sialoadhesin;sialylation;Site;sperm cell;Structure;success;sugar;Surface;System;Techniques;Testing;Tissues;Training;transcription factor;transcriptome sequencing;Tube;Universities;Uterus;Writing

PROJECT_TITLE: Siglecs in the Porcine Oviduct: Roles in the Sperm Reservoir and Sperm Immune Response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-B(20)L]


ADMINISTERING_IC: DE

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE Head and neck squamous cell carcinoma (HNSCC) remains a deadly malignancy around the world and in the US HNSCC incidence is rising at an epidemic rate, fueled largely by the human papillomavirus (HPV). Our data indicate that generation of replication stress via RAD51 inhibition can directly target the E7 oncogene critical to HPV+HNSCC and may generate superior anti- tumor activity compared to standard of care cisplatin, when combined with radiation. We also demonstrated that targeting of RAD51 increased sensitivity to radiation in HPV-negative HNSCC, which is often refractory to conventional chemo-radiation strategies.

PI_NAMEs: FREDERICK, MITCHELL J.;OSMAN, ABDULLAH ALI (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Anatomy;Area;Automobile Driving;Biology;Bone Marrow;Cancer Patient;cancer subtypes;Cell Cycle;Cell Line;Cell Survival;Cells;Cessation of life;chemoradiation;chemotherapy;Cisplatin;Clinical;Clinical Trials;Complex;Cytoprotection;Data;Defect;Disease;disorder risk;DNA Damage;DNA Repair;DNA Repair Gene;Down-Regulation;Drug Combinations;drug sensitivity;Drug Targeting;efficacy evaluation;Epidemic;Etiology;Gene Expression;Generations;Genes;Genomics;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Hematopoietic;Heterogeneity;high risk;homologous recombination;HPV E7;HPV negative;HPV oropharyngeal cancer;HPV positive;HPV-High Risk;HPV-negative head and neck cancer;Human;human model;Human papilloma virus infection;human papilloma virus oncogene;Human Papillomavirus;Immunocompetent;improved;Incidence;Individual;Inferior;inhibitor;Laboratories;Lead;Link;Location;Low risk HPV;malignant mouth neoplasm;Malignant Neoplasms;malignant oropharynx neoplasm;Mediator;Mitotic;Molecular;Morbidity - disease rate;mouse model;Mus;Natural History;new therapeutic target;Normal Cell;NOTCH1 gene;Oncogenes;Operative Surgical Procedures;oral HPV-positive head and neck cancers;Outcome;overexpression;overtreatment;patient derived xenograft model;Patients;Pattern;Pharmaceutical Preparations;Phosphotransferases;Pre-Clinical Model;precision oncology;Predisposition;Primary Neoplasm;Prognosis;protein function;Proteins;Publishing;Radiation;recombinational repair;Refractory;replication stress;Resistance;response;Risk;Risk Factors;Salivary Glands;Sampling;side effect;Smoker;Smoking;standard of care;stem cells;Survival Rate;targeted agent;Testing;Tobacco use;Toxic effect;TP53 gene;tumor;tumor growth;Tumor Suppressor Proteins;tumor-immune system interactions;Virus Diseases;Virus Replication;Work;Xenograft Model

PROJECT_TITLE: Targeting replication stress and homologous recombination repair mechanisms in HPV-positive and negative head and neck cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: Chicago

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative The purpose of the Cancer Health Equity Career Development Program (CHECDP) at the University of Illinois at Chicago is to continue to train a diverse cadre of scientists with the skills and experience needed to become independent scientists and address the significant challenges and opportunities of cancer-related health inequities and to advance health equity policies at the local and national levels. We propose to continue the successful CHECDP for years 31-35.

PI_NAMEs: FITZGIBBON, MARIAN L. (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Cancer health equity;career development;Program Development

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: Familial Alzheimer’s disease (FAD) is caused by mutations in the substrate and enzyme that produce amyloid peptide, which deposits as plaques in the brain. Understanding the changes in structure and function induced by these mutations is essential to deciphering the etiology of FAD and developing strategies for the discovery of FAD therapeutics. The goal of this project is to use chemical probes along with structural and computational approaches to elucidate how FAD mutations in the enzyme, gamma-secretase, alter its structure and function.

PI_NAMEs: WOLFE, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Active Sites;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease therapeutic;Amino Acids;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid peptide;analog;Aspartate;Aspartic Endopeptidases;beta secretase;Binding;Brain;Carboxypeptidase;Carboxypeptidase A;Cerebrum;Chemicals;Complex;Computational Biology;crosslink;Cryoelectron Microscopy;Deposition;design;Disease Pathway;dominant genetic mutation;enzyme substrate complex;Enzymes;Etiology;familial Alzheimer disease;Functional disorder;gain of function;gamma secretase;Generations;Goals;Induced Mutation;Inherited;inhibitor;insight;Lateral;Link;loss of function;Membrane;Membrane Proteins;middle age;mimetics;Missense Mutation;Modeling;Molecular;Molecular Conformation;molecular dynamics;mutant;Mutation;Neurodegenerative Disorders;Pathogenesis;Pathogenicity;Peptide Hydrolases;Peptides;peptidomimetics;presenilin;presenilin-1;presenilin-2;Prevention strategy;Proteolysis;Reporting;Senile Plaques;Stress;structural biology;Structure;Substrate Domain;Substrate Interaction;synthetic peptide;therapeutically effective;Time;Transmembrane Domain;Variant;Visualization;Water

PROJECT_TITLE: Structure and Function of Gamma-Secretase in Familial Alzheimer's Disease

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Depression;Genetics;Human Genome;Major Depressive Disorder;Mental Health;Mental Illness;Prevention;Serious Mental Illness;Suicide

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Major depressive disorder (MDD) is a common cause of disability, suicide, and adverse life/health outcomes. We propose to identify the subset of people with MDD who are especially impacted by MDD. We will do this is a highly rigorous way via very similar analyses in large samples from the US, UK, Sweden, Denmark, and Norway. We will use all available data (treatment history, other medical and psychiatric problems, and genetic information). Our goal is to predict those who are likely to develop the worst forms of MDD early in their illness. Successful predictions will enable us to craft interventions in future studies to improve the health of MDD patients who are the most severely ill.

PI_NAMEs: SULLIVAN, PATRICK F (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Affect;Age;Algorithms;biobank;Body mass index;Clinical;clinical predictors;clinically relevant;cohort;Collaborations;completed suicide;Computer software;Data;data analysis pipeline;data harmonization;Data Set;Denmark;density;design;Development;Diagnosis;Diagnostic;disability;Family;follow-up;Future;Generations;Genetic;genetic information;genetic pedigree;Genetic Risk;genome wide association study;genome-wide;genomic data;Genomics;Goals;Health;Healthcare;Healthcare Systems;Hereditary Disease;Heritability;improved;Individual;Infrastructure;Inherited;Intention;Intervention;Life;Major Depressive Disorder;Medical;Medical History;meetings;Mental disorders;Methods;Modeling;Norway;Outcome;Paper;Patients;Persons;Phenotype;phenotypic data;Population;prediction algorithm;predictive modeling;Preventive;psychiatric genomics;Psychiatry;Psychoses;Quality of life;Recording of previous events;recruit;Reproducibility;Research Personnel;Retrospective cohort;Risk;Risk Factors;risk variant;Sample Size;Sampling;Scheme;Scotland;Secure;Severities;sex;Smoking;Social Functioning;Suicide;Sweden;Tail;tertiary prevention;Testing;therapy resistant;Training;translational goal;treatment pattern;Twin Multiple Birth;Validation;Work

PROJECT_TITLE: A Trans-Nordic Study of Extreme Major Depression

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Liver Disease;Lung;Maternal Health;Maternal Morbidity and Mortality;Orphan Drug;Patient Safety;Prevention;Rare Diseases;Tuberculosis;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative Pregnant and postpartum women living with HIV (WLWH) experience high rates of hepatotoxicity with isoniazid preventive therapy (IPT), but there are limited data on underlying toxicity mechanisms in this population. Using a case-control design, the proposed research will characterize the pharmacology of isoniazid metabolites and toxicity biomarkers using metabolomics and inflammatory cytokines in pregnant and postpartum WLWH. This work will help address critical knowledge gaps in the use of IPT in this population, and also establish Dr. Kristina Brooks as an independent investigator in TB/HIV pharmacology and adverse drug reactions.

PI_NAMEs: BROOKS, KRISTINA MARIE (contact)

PROGRAM_OFFICER_NAME: CLELAND, NAANA G

PROJECT_TERMS: Acetyltransferase;Acids;Address;Adult;adverse drug reaction;Area;Biological Markers;biomarker identification;Biometry;career;case control;cell type;Characteristics;Clinical;Clinical Pharmacology;Clinical Trials;Clinical Trials Network;cohort;cytokine;Data;data integration;design;Development;drug induced liver injury;Drug Kinetics;Early Diagnosis;Early treatment;effective therapy;Ensure;Enzymes;experience;Foundations;Gestational Age;glomerular filtration;Goals;Health;Helper-Inducer T-Lymphocyte;Hepatotoxicity;high risk;HIV;HIV/TB;Human;Immune;immune function;Immunologic Markers;Immunologics;Immunology;Individual;infant morbidity/mortality;Inflammatory;Inflammatory Response;insight;interest;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;isoniazid;Kidney;Knowledge;Laboratories;Late pregnancy;Link;Literature;Logistic Regressions;maternal morbidity;Maternal Mortality;Measures;Mediating;Mentors;Metabolic;metabolic phenotype;metabolomics;Modeling;mortality;Outcome;Parents;Patients;Pharmaceutical Preparations;Pharmacogenetics;Pharmacology;Phase;Physiological;Population;post pregnancy;Postpartum Period;Postpartum Women;Predictive Value;Pregnancy;Pregnant Women;Prevalence;prevent;Preventive therapy;Recommendation;Regimen;Research;Research Personnel;Research Priority;response;Safety;Sampling;Site;Special Population;statistics;Testing;Toxic effect;Training;treatment arm;Tuberculosis;tuberculosis treatment;United States National Institutes of Health;uptake;Vulnerable Populations;Woman;Women's cohort;Work;World Health Organization

PROJECT_TITLE: Biomarkers of Hepatotoxicity in Women Living with HIV and Latent TB

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: WILMINGTON

ORG_NAME: NEMOURS CHILDREN'S HOSPITAL, DELAWARE

ORG_STATE: DE

PHR: NARRATIVE Youth with type 1 diabetes (T1D), particularly those from ethnic minority and lower financial resource backgrounds, exhibit significant difficulty adhering to the complicated treatment regimen for T1D, placing them at risk for adverse acute and long-term health outcomes. Although evidence-based behavioral interventions are efficacious at improving health outcomes for youth with T1D, few families receive this care. Effective implementation strategies, or methods for increasing the integration of behavioral intervention into standard care for youth with T1D, and additional data supporting effectiveness of this intervention when delivered as part of standard care can contribute meaningfully to improving the overall health of youth with T1D.

PI_NAMEs: PRICE, JULIA ELIZABETH WINTERROWD (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Adherence;Adolescent;Affect;Area;Attitude;Awareness;Behavior Therapy;Behavioral;behavioral health;Behavioral Research;Belief;burden of illness;care delivery;Caring;cerivastatin;Cessation of life;Childhood;Chronic;Chronic Disease;Clinic;Complex;Complications of Diabetes Mellitus;Conduct Clinical Trials;Consolidated Framework for Implementation Research;Data;design;Development;Diabetes Mellitus;diabetes mellitus therapy;Diabetic Coma;Diabetic Ketoacidosis;Disease;Educational Materials;Effectiveness;Effectiveness of Interventions;effectiveness/implementation trial;efficacious intervention;Electronic Health Record;Eligibility Determination;Endocrinology;Environment;ethnic minority;Evaluation;evidence base;Evidence based practice;Exhibits;experience;experimental study;Family;Feedback;Funding;glycemic control;Goals;Health;health care disparity;Health Personnel;Healthcare;Healthy People 2020;Heart Diseases;implementation facilitators;implementation science;implementation strategy;implementation trial;improved;Individual;innovation;Institution;Insulin-Dependent Diabetes Mellitus;integrated care;Interview;K-Series Research Career Programs;Knowledge;Leadership;Literature;Low income;Medical;Mentors;Methods;Outcome;Parents;Patient Schedules;Patient-Focused Outcomes;Patients;Pattern;Pediatric Hospitals;Penetration;Persons;physical conditioning;pilot trial;population health;Price;Process;programs;Provider;psychosocial;Public Health Informatics;Quality of life;Randomized;Recommendation;Regimen;Research;Research Methodology;Research Personnel;Research Support;Resources;Risk;Sampling;Services;Site;skill acquisition;Specific qualifier value;standard care;System;Testing;testing uptake;theories;Training;Treatment Protocols;United States;uptake;Youth

PROJECT_TITLE: Uptake of Evidence-Based Behavioral Intervention for Pediatric Type 1 Diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Infectious Diseases

PHR: NARRATIVE Staphylococcus aureus is one of the most dangerous and costly bacterial pathogens in the United States. This proposal will uncover the mechanism by which the respiratory metabolism regulates virulence and advance our understanding on the adaptive mechanisms that enable this organism to be such a versatile pathogen.

PI_NAMEs: GENNIS, ROBERT B (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Aerobic;Affect;alpha Toxin;Animals;Bacteria;Biochemical;Biochemistry;Bioenergetics;Cell Physiology;Cells;cost;Cytochrome c Reductase;Dangerousness;Data;Development;differential expression;Disease;Elements;Environment;Enzymes;Evolution;flexibility;Gene Expression Profiling;Generations;Genetic;Genus staphylococcus;Goals;Growth;Human body;In Vitro;Infection;interdisciplinary approach;Kinetics;Knock-out;Knowledge;Link;Membrane;Membrane Proteins;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;Microbial Biofilms;microfluidic technology;Molecular;Monitor;Morbidity - disease rate;mortality;Multi-Drug Resistance;NADH;Nebraska;new therapeutic target;Nitrates;Nutrient;Organ;Organism;oxidation;Oxidation-Reduction;Oxygen;pathogen;Pathogenesis;pathogenic bacteria;Pattern;Process;Production;promoter;protein purification;Proteins;Proteomics;Qualifying;Regulation;Respiration;respiratory;Respiratory Chain;respiratory enzyme;Role;sensor histidine kinase;Signal Induction;Signal Transduction;Signaling Molecule;Site;Staphylococcus aureus;Staphylococcus aureus infection;System;Techniques;Technology;Testing;therapeutically effective;United States;Universities;Variant;Virulence;Virulence Factors;Vitamin K 2

PROJECT_TITLE: The molecular mechanism linking respiratory NADH oxidation and virulence in Staphylococcus aureus

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: SANTA BARBARA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: PROJECT NARRATIVE: Neurodegenerative Disorders, such as Alzheimer's Disease and other dementias, as well as the general aging process, are characterized the distinct loss of vital synaptic connections in the brain21; as of 2019, diseases such as this affect a devastating 57.4-million people worldwide22. The proposed research seeks to break the mold of conventional research on Neurodegeneration, exploring a unique phylum of invertebrates, the tardigrade, whose entire nervous system can survive extreme environmental stressors without observable impact on nervous system function. Our work will unveil and subsequently assess the utility of novel homologous targets for a therapeutic generation with the potential to revolutionize our understanding of the limits of fundamental animal physiology as well as neurodegenerative patient outcomes.

PI_NAMEs: KIRK, MOLLY J (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: abeta toxicity;Acetylation;adeno-associated viral vector;Affect;Age;Aging;aging process;Alzheimer's Disease;Amyloid beta-Protein;Anatomy;Animals;animation;Ankyrins;aversive conditioning;Behavioral;Biological Assay;Brain;Caenorhabditis elegans;Centrifugation;Chemical Synapse;cohort;Collaborations;Data;Dehydration;Dementia;density;Desiccation;Development;Disease;Environment;environmental stressor;Excision;Exposure to;Force of Gravity;Fortification;Freezing;Gap Junctions;Generations;genetic regulatory protein;Genetic Transcription;Goals;Head;Health;Homologous Gene;Hour;Human;Hydration status;Hypergravity;In Vitro;Invertebrates;knock-down;Length;long term memory;Maintenance;Manuals;Memory;memory retention;Metabolic;Modeling;Molds;Molecular;Molecular Target;Mollies;Monitor;Morphology;Motion;mouse model;Mus;Natural regeneration;Nerve Degeneration;Nervous System;Nervous System Disorder;Nervous System Physiology;neural;Neurites;Neurodegenerative Disorders;neuroligin 1;neuronal survival;Neurons;new therapeutic target;normal aging;novel;Patient-Focused Outcomes;Persons;Phenotype;Phosphorylation;Physiology;Planet Earth;Population;Predisposition;presynaptic;prevent;Process;Proteins;Proteome;Proteomics;Protocols documentation;Recovery;regenerative;Regenerative capacity;Regulation;Research;resilience;response;RNA Interference;Role;Stress;Suspensions;Synapses;Synapsins;synaptic function;System;system architecture;Testing;Therapeutic;therapeutic development;Time;transcriptome sequencing;transcriptomics;Tubulin;Up-Regulation;Visualization;Walking;Water;Work

PROJECT_TITLE: Neuroresilience to hyper-gravity and desiccation in tardigrade Hypsibius exemplaris


NIH_SPENDING_CATS: Aging;Neurodegenerative;Neurosciences

PHR: Project Narrative In humans, an age-related decline in neuromuscular function is associated with loss of muscle mass (sarcopenia), increased frailty and a degradation of both health and quality of life. Using three independent mouse lines, newly implicated in homeostatic plasticity, we will determine whether homeostatic plasticity functions to counteract the insidious effects of age-related neuromuscular decline over the normal lifespan.

PI_NAMEs: DAVIS, GRAEME W (contact)

PROJECT_TERMS: Adult;Adverse effects;adverse outcome;Age;age acceleration;age effect;age related;age related changes;age related decline;aged;Aging;aging population;aging process;Anatomy;Antibodies;Behavior;Biochemical;Cognitive;combat;Data;Development;diet and exercise;Disease Progression;Drosophila genus;epithelial Na+ channel;frailty;Future;Genes;Genetic;Health;Human;In Situ;Injury;Integrins;Knock-out;life span;Life Style;Maintenance;Mediating;Molecular;Motor;mouse model;Mouse Strains;Mus;Muscle;Muscle denervation procedure;muscle form;Muscle function;Muscular Atrophy;Mutation;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;neuromuscular;neuromuscular function;Neuromuscular Junction;neuromuscular system;neuroprotection;neurotransmitter release;normal aging;novel;novel marker;Onset of illness;Paper;pharmacologic;Physiological;preservation;presynaptic;Publishing;Quality of life;Research;resilience;Risk Factors;Rodent Model;Role;sarcopenia;Semaphorin-3A;Semaphorins;Signal Transduction;Synapses;synaptic function;Testing;Therapeutic;tool

PROJECT_TITLE: Homeostatic Neuroprotection in the Aging Nervous System

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Oligodendrocytes and microglia are two types of glial cells with critical functions in the brain. Despite their important roles in health and disease, many questions remain unanswered about the genetic mechanisms that control the development and function of these cells. The goal of this project is to use the powerful genetic and cellular approaches in the zebrafish model system to discover new genes with essential functions in oligodendrocytes and microglia. The mechanistic insight gained from these studies will advance our fundamental understanding of the central nervous system, illuminate the pathways that are disrupted in diseases of the brain, and suggest avenues toward therapies for neurological disorders.

PI_NAMEs: TALBOT, WILLIAM S (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Address;Apoptotic;Axon;axon injury;Biological Models;Brain;Brain Diseases;Cell Physiology;Cells;Central Nervous System;critical period;Development;Disease;Genes;Genetic;glial cell development;Goals;Health;in vivo imaging;Infection;insight;Microglia;Molecular;Motility;mutation screening;Myelin;Myelin Sheath;myelination;Nervous System Disorder;Neuroglia;Neuronal Plasticity;Oligodendroglia;pathogen;Pathway interactions;Phagocytes;Process;remyelination;Research;Role;Vertebrates;Zebrafish

PROJECT_TITLE: Genetic and cellular analysis of glial development and function in vertebrates


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Alzheimer's disease is considered the most costly and burdensome disease in the U.S, and its public health impact will only grow with the increase of 65-75 year olds in the next decade. Paralleling cardiovascular disease and cancer, it is now widely recognized that a key to slowing disease progression is early identification during pre-dementia phases. With cognitive and biomarker data beginning when participants were in their 50s, the longitudinal VETSA project stands to advance progress toward early identification, which may, in turn, improve quality of life and reduce societal burden.

PI_NAMEs: ELMAN, JEREMY A;FRANZ, CAROL ELAINE;PANIZZON, MATTHEW S (contact);REYNOLDS, CHANDRA A

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Acceleration;Accounting;Address;Adult;Age;age related changes;Age Years;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Anxiety;Binding;Biological Assay;Biological Markers;Biometry;Blood;Cardiovascular Diseases;causal model;Classification;Cognition;Cognitive;cognitive ability;cognitive change;cognitive function;cognitive performance;cognitive process;cognitive reserve;cognitive testing;Communities;Consensus;cost;Data;Dementia;design;Detection;Diagnosis;Digit structure;Disease;Disease Progression;Early identification;Environment;Episodic memory;Etiology;executive function;familial Alzheimer disease;Family;Funding;Genetic;Genetic Crosses;genome-wide;Genotype;Growth;Health;Heritability;Hour;Impaired cognition;improved;indexing;Individual;Individual Differences;Knowledge;Lead;Light;Malignant Neoplasms;Measures;Mediator;Medical;Medical History;Memory;memory recall;Mendelian randomization;Meta-Analysis;middle age;mild cognitive impairment;Modeling;Mydriasis;Nerve Degeneration;neurofilament;non-demented;novel;older adult;Participant;Pathologic;Pattern;Phase;Plasma;polygenic risk score;Populations at Risk;Positioning Attribute;pre-clinical;predictive marker;prevent;Process;protective factors;psychosocial;Public Health;Pupil;Quality of life;Questionnaires;Research;Resources;response;Risk;Risk Factors;Risk Marker;Sampling;Savings;Short-Term Memory;Staging;System;tau Proteins;Telephone;Testing;Time;Twin Multiple Birth;Twin Studies;United States National Institutes of Health;Update;Vietnam;virtual;Visit;Visual;Work

PROJECT_TITLE: The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Hypertension;Neurodegenerative;Neurosciences;Prevention;Telehealth

ORG_CITY: TUCSON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Persons with mild cognitive impairment (PwMCI) are at higher than average risk for nonadherence to medications due to the COVID-19 pandemic. Hypertension is prevalent among PwMCI and nonadherence to medication increases the risk of accelerated cognitive decline through cerebrovascular disease. This project will adapt an existing hypertension medication self-management system to develop Medication Education, Decision Support, Reminding, and Monitoring-Memory (MEDSReM-M) to meet the needs and abilities of PwMCI and conduct an efficacy study to assess medication adherence benefits.

PI_NAMEs: INSEL, KATHLEEN C (contact);MUDAR, RAKSHA ANAND

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Acceleration;Activities of Daily Living;Address;Adherence;Adoption;Adult;Age;Android;Anti-Hypertensive Agents;Attention;Blood Pressure;cardiovascular risk factor;Caring;Cerebrovascular Disorders;Chronic;Cognition;Cognitive;cognitive ability;cognitive function;cognitive skill;Collaborations;Communities;comorbidity;Compensation;Competence;Control Groups;COVID-19 pandemic;COVID-19 pandemic effects;Dementia;dementia risk;design;Deterioration;Development;digital;digital health;digital intervention;digital technology;digital treatment;Dose;Drug Prescriptions;Education;Educational Intervention;efficacy evaluation;efficacy study;Ensure;Evaluation;experience;Failure;Family;Friends;Future;group intervention;Health;Health Personnel;Health Professional;Health system;Healthcare;Heart failure;heuristics;high risk;Human;Hypertension;Impaired cognition;Impairment;improved;Individual;Intervention;Interview;Learning Skill;lonely individuals;medication compliance;Medication Management;medication nonadherence;member;Memory;mHealth;mHealth self-management;mild cognitive impairment;Monitor;Myocardial Infarction;older adult;Older Population;Outcome;Persons;Pharmaceutical Preparations;Population;Populations at Risk;preservation;procedural memory;prospective memory;Quality of life;randomized, clinical trials;Randomized, Controlled Trials;rate of change;Reminder Systems;remote monitoring;Risk;Self Determination;Self Management;Self Medication;Standardization;Stroke;Structure;Support System;support tools;System;Technology;Testing;theories;Time;tool;usability;user centered design;Vulnerable Populations;web portal

PROJECT_TITLE: Digital Technology to Support Adherence to Hypertension Medications for Older Adults with Mild Cognitive Impairment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-M(54)R]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome

ORG_CITY: ITHACA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Salmonella infections present a public health threat in the US and around the world. We aim to investigate the means by which chemical signals of the gut reduce Salmonella virulence and carriage. This research has the potential to identify new and innovative means to reduce or prevent salmonellosis.

PI_NAMEs: ALTIER, CRAIG  (contact)

PROJECT_TERMS: 129X1/SvJ Mouse;Acids;Affect;Amino Acids;Animals;Antibiotics;Bacteria;Behavior;Binding;Biological;Chemicals;Clinical;Coculture Techniques;colonization resistance;Country;Dimerization;Disease;DNA;DNA Binding;Ectopic Expression;Environment;Equilibrium;Escherichia coli;Fatty Acids;foodborne pathogen;Formates;Gammaproteobacteria;Gene Expression;Gene Fusion;Genes;Genetic Transcription;Goals;Growth;gut colonization;Health;Human;improved;in vivo;Infection;Inflammation;innovation;interspecies communication;intestinal epithelium;Intestines;Invaded;Large Intestine;Ligands;Location;long chain fatty acid;Measures;microbiota;Modeling;Molecular;mouse model;Mus;mutant;novel;novel strategies;Outcome Study;pathogen;Population;Positioning Attribute;predictive modeling;prevent;Process;Production;Proteins;Public Health;quorum sensing;Recombinants;Repression;Research;resistant strain;response;Salmonella;Salmonella infections;Scheme;Siblings;Signal Induction;Signal Repression;Signal Transduction;Signaling Molecule;Structure;Testing;Transcription Coactivator;Virulence;Work

PROJECT_TITLE: Interspecies Bacterial Signaling to Regulate Salmonella Virulence

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: The goal of this proposal is to define how the ill-defined protein, FIT2, regulates: 1) the amount and types of lipids (i.e., fats) loaded onto particles (known as VLDL) that can cause heart disease; and, 2) how these resulting lipid-rich VLDL particles are captured in membrane containers that exit the part of the cell called the Endoplasmic Reticulum (ER). These studies will capitalize on new mouse models having liver-specific deficiency FIT2, as well as cell culture systems that the investigators have used to decipher the molecular mechanisms that control upstream, early events during the biogenesis of VLDL in the ER. The relationship of FIT2 to non-alcoholic fatty liver disease and steatohepatitis along with atherosclerosis (the basis of coronary heart disease and heart attacks) will be established, and these and all other hypothesis-driven studies will be made possible by close collaborations with other experts.

PI_NAMEs: BRODSKY, JEFFREY L.;FISHER, EDWARD A (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Acceleration;Adipocytes;Affect;Anabolism;Apolipoproteins;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Biogenesis;biological adaptation to stress;Biological Assay;Cell Culture System;Cell Line;Cell secretion;Cells;Cholesterol;Cholesterol Esters;Chylomicrons;Circulation;Clinic;clinically relevant;Collaborations;Coronary heart disease;Data;Databases;defined contribution;Degradation Pathway;Endoplasmic Reticulum;endoplasmic reticulum stress;Endothelial Cells;Engineering;Enterocytes;Event;experience;Fatty acid glycerol esters;Fatty Acids;fatty liver disease;Generations;Goals;Golgi Apparatus;Heart Diseases;Hepatic;Hepatocyte;High Fat Diet;Homeostasis;Human;hypercholesterolemia;Hypertriglyceridemia;In Vitro;in vivo;Incubated;International;Kinetics;Lipids;Lipoproteins;Liver;LoxP-flanked allele;Macrophage;Mediating;Membrane;Membrane Lipids;Membrane Proteins;Metabolic;Metabolism;microsomal triglyceride transfer protein;Modeling;Molecular;mouse model;Mus;Myocardial Infarction;Names;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Outcome;Output;overexpression;Paper;particle;Pathogenicity;Pathway interactions;Peripheral;Pharmaceutical Preparations;Pilot Projects;Plasma;Play;Predisposition;Production;Property;protein degradation;Protein Secretion;Proteins;Publications;Publishing;Research Personnel;Rodent Model;Role;Sampling;Severities;Smooth Endoplasmic Reticulum;Source;Steatohepatitis;System;Testing;Tissues;Transcript;transcriptomics;Triglycerides;Very low density lipoprotein;Vesicle;Work

PROJECT_TITLE: The role of FIT2 in VLDL assembly, hepatic triglyceride homeostasis, and lipoprotein atherogenicity

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Eating Disorders;Mental Health;Neurosciences;Nutrition;Obesity;Pediatric;Prevention

PHR: PROJECT NARRATIVE Overweight/obesity and loss of control eating (characterized by the sense that one cannot control what or how much one is eating) are prevalent among children and adolescents, and both are associated with serious medical and psychosocial health complications. Although our recently published data suggest that youth with these conditions may have relative deficits in neurocognitive functioning, particularly working memory, understanding of how these processes and their neural correlates are related to change and stability in eating- and weight-related outcomes over time is limited, thereby impeding development of targeted, optimally timed interventions. The proposed study aims to assess prospective associations between general and food-specific executive functioning and underlying neural substrates, and eating and weight outcomes among children at varying levels of risk overweight/obesity and eating disorders, which will help guide research efforts towards the development of effective prevention and intervention strategies.

PI_NAMEs: GOLDSCHMIDT, ANDREA BETH (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Address;Adolescence;Adolescent;Affect;Age;Area;Behavior;Behavioral;Body mass index;Body Weight Changes;Body Weight decreased;Brain;brain pathway;Categories;Child;Childhood;Chronic;Clinical;Cognitive;Communities;comorbidity;Data;Decision Making;design;Development;dietary;Disease;Dorsal;Early Intervention;Eating;Eating Behavior;Eating Disorders;eating pathology;Emotional;Emotions;Etiology;excessive weight gain;Executive Dysfunction;executive function;follow-up;Food;Functional Magnetic Resonance Imaging;Future;Health;Healthcare Systems;healthy weight;Height;Impairment;improved;Impulsivity;inter-individual variation;Intervention;Investigation;Knowledge;loss of control over eating;Maintenance;Measures;Medical;middle childhood;Modeling;Nature;negative affect;neglect;neural;neural correlate;Neural Pathways;Neurocognitive;neuroimaging;neuromechanism;Neurophysiology - biologic function;Obesity;obesity in children;Outcome;Overweight;Parietal Lobe;Participant;Pathway interactions;Pattern;Performance;Phenotype;Prefrontal Cortex;prevent;Prevention strategy;preventive intervention;Principal Investigator;Process;process improvement;prospective;Prospective Studies;Protocols documentation;psychosocial;Public Health;Publishing;Regulation;Remittance;Research;Research Design;restraint;Risk;Role;Sampling;Scientific Advances and Accomplishments;Short-Term Memory;Specificity;Structure;therapy development;Time;Training;Weight;Weight Gain;Weight maintenance regimen;Youth

PROJECT_TITLE: Executive Functioning, Weight Trajectories, and Loss of Control Eating in Children with Overweight/Obesity: A Prospective Study

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Social Determinants of Health;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The burden of HIV among female sex workers (FSW) in South Africa is disproportionally high and addressing the treatment needs of FSW is critical to supporting optimal health and wellbeing, reducing onward transmission, and altering the HIV epidemic; how to feasibly and effectively implement strategies to support the unmet needs of those most marginalized remains often unclear. This study will leverage existing data collected over 18-months among a cohort of 777 non-virally suppressed FSW living with HIV to understanding longitudinal patterns of engagement with HIV treatment support strategies, the role engagement had on sustained retention and viral suppression, and the mechanisms through which implementation outcomes (i.e., fidelity, feasibility, and appropriateness) influenced sustained retention and viral suppression. Results will inform the measurement, optimization, and dissemination of HIV implementation strategies aimed to increase HIV treatment access, retention, and viral suppression among FSW living with HIV at greatest need.

PI_NAMEs: COMINS, CARLY  (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;antiretroviral therapy;Award;Caring;Case Management;Characteristics;Clinical;cohort;Consolidated Framework for Implementation Research;contextual factors;Country;Data;data cleaning;Decentralization;Development;Dose;Drops;Ensure;Epidemic;Epidemiologist;Evaluation;Evidence based intervention;experience;Face;Fellowship;female sex worker;follow-up;Fostering;Goals;Health;Health Benefit;Health Services Accessibility;Heterogeneity;HIV;implementation context;implementation determinants;implementation fidelity;implementation outcomes;implementation research;implementation strategy;implementation/effectiveness;improved;Infrastructure;Intervention;Interview;lens;marginalization;marginalized population;Measurement;Measures;Mentorship;Methods;Modeling;multi-component intervention;National Institute of Mental Health;novel;Nurses;Outcome;Ownership;Participant;Pattern;peer;Personal Satisfaction;Persons;Population;Probability;psychosocial;Randomized;Research;Role;Scientist;Sequential Multiple Assignment Randomized Trial;sex;skills;South Africa;Specific qualifier value;Telephone;Testing;texting support;Time;Training;transmission process;treatment optimization;Treatment outcome;treatment strategy;uptake;Viral;Visit;Woman;women's outcomes;Work

PROJECT_TITLE: HIV Treatment Strategies for Female Sex Workers Living with HIV in South Africa: Engagement Trajectories and Implementation Determinants


ORG_CITY: FLUSHING

ORG_DEPT: BIOLOGY

ORG_NAME: QUEENS COLLEGE

PHR: U-RISE at Queens College, CUNY, Narrative This grant requests support for the training of students from diverse backgrounds and for their increased representation and success in the biomedical sciences within Queens College. We have a track record of mentoring such trainees for the last 18 years through the MARC U-STAR program (set to expire in May 2022). The proposed project will ensure that we can continue to serve the diverse community of Queens County via the U-RISE mechanism.

PI_NAMEs: ALVARADO, SEBASTIAN GASTON;TAJERIAN, MARAL  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Affect;Aromatase;Biomedical Research;career;Caucasians;Cities;college;Communities;Country;Data;Dedications;Degree Completion;Development;Discipline;Educational workshop;Eligibility Determination;Environment;equity, diversity, and inclusion;Ethics;ethnic diversity;faculty mentor;Funding;Funding Mechanisms;Graduate Degree;graduate school;Grant;Institutionalization;New York;programs;Publications;Research;Research Personnel;Research Training;Science;Services;Social Mobility;STEM field;Students;success;Talents;Training;Training and Infrastructure;undergraduate research;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities

PROJECT_TITLE: U-RISE at Queens College, CUNY

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Asthma;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Pediatric;Social Determinants of Health

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative This project will establish a clinical research center to conduct network wide research to develop asthma treatments for children living in low-income urban settings. The site-specific research will investigate molecular mechanisms that could explain the heterogeneous clinical phenotypes and how allergy, pollution and stress affect these mechanisms. The knowledge gained from the network and site-specific studies will improve asthma outcome and has the potential to lead to novel therapeutic approaches.

PI_NAMEs: KATTAN, MEYER  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Accounting;Address;Adult;Affect;Age;Air Pollution;airway epithelium;Allergens;Allergic;Asthma;asthmatic;asthmatic patient;atopy;Biological Markers;Biological Products;carrier status;Cells;Censuses;Characteristics;Child;Childhood Asthma;clinical phenotype;Clinical Research;Clinical Trials;Cluster Analysis;Code;Communities;Coupled;cytokine;Development;Dictyoptera;Disease;disorder control;Environment;Environmental Exposure;Epithelial Cells;experience;Exposure to;follow-up;Genetic;Genetic Polymorphism;Genetic study;Goals;Guidelines;Heterozygote;Hypersensitivity;IgE;IL6 gene;Immune system;Impairment;improved;indexing;Individual;Individual Differences;indoor concentrations;Inflammation;Inflammatory Response;inner city;Institution;Interleukin 6 Receptor;Interleukin-1;Interleukin-2;Interleukin-6;Interleukins;Investigation;Irritants;Knowledge;Lead;Low income;Measures;Mediating;Medical center;Mendelian disorder;Molecular;Morbidity - disease rate;Nasal Epithelium;National Institute of Allergy and Infectious Disease;neutrophil;new therapeutic target;New York;New York City;Nitrogen Dioxide;novel therapeutic intervention;Outcome;Participant;Pathogenesis;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Phenotype;pollutant;Pollution;Population;Prevention approach;Production;programs;prospective;Protocols documentation;receptor;receptor binding;Receptor Signaling;Recording of previous events;Recurrence;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;Resources;response;Role;Sampling;Severities;Severity of illness;Signal Transduction;Site;skills;Stress;Symptoms;systemic inflammatory response;Testing;Universities;Urban Community;urban setting;Variant;Wheezing

PROJECT_TITLE: CAUSE Clinical Research Center New York (CAUSE-CRC)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This proposal is aimed at studying how neural circuits acquire and store prospective and retrospective associations between reward predictors and rewards. Since maladaptive learning and memory are common in many mental illnesses, the mechanisms learned here could improve our understanding of the specific nature of these deficits.

PI_NAMEs: K NAMBOODIRI, VIJAY MOHAN  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Animals;Behavior;Behavior Control;Behavioral;Brain;Calcium;Cues;Data;Evolution;excitatory neuron;expectation;experimental study;Extinction;fitness;Image;improved;in vivo calcium imaging;Individual;Learning;learning strategy;Medial;Mediating;member;Memory;memory acquisition;memory encoding;Memory impairment;Mental disorders;Mus;Nature;neural circuit;neuronal circuitry;Neurons;novel;Nucleus Accumbens;optogenetics;Outcome;Output;Pathway interactions;Population;Probability;prospective;prospective memory;Recording of previous events;recruit;response;Rewards;sound;Structure;Testing;Theoretical model;Therapeutic;Training;two-photon;Ventral Tegmental Area

PROJECT_TITLE: Prospective and retrospective learning in orbitofrontal cortex

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]