PHR: Narrative Our PO1 program has the ambition to position anti-glycan antibodies as a therapeutic alternative and/or complement to the current limited chemical arsenal of antibiotics. High affinity anti-glycan antibodies will be produced and characterized by a complementary expert group of chemists, bacteriologists, immunologists, and structural biologists with a focus on Staphylococcus aureus. Preliminary data, including in vivo studies, attest of the pertinence and feasibility of the project.

PI_NAMEs: TEYTON, LUC  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Acetylation;Achievement;Affinity;Animal Model;Antibiotic Resistance;Antibiotics;Antibodies;Antibody Affinity;Antigens;B-Lymphocytes;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;Bacteriology;Binding;Carbohydrates;Cell Wall;Characteristics;Chemicals;Chemistry;chemotherapy;Communication;Complement;Complex;Dangerousness;Data;design;Development;Dimensions;Drug resistance;Fab Immunoglobulins;Fc Immunoglobulins;fighting;Fimbriae Proteins;Glycopeptides;glycosylation;Goals;Health;Immune;Immune response;Immune system;immunogenic;Immunoglobulin Fragments;Immunologist;Immunology;Immunotherapy;in vivo;in vivo Model;Infectious Skin Diseases;Klebsiella pneumoniae;Knowledge;Life;Link;Mediating;Medical;Modification;Molecular;Monoclonal Antibodies;monomer;Mus;nanoparticle delivery;Nature;Neisseria gonorrhoeae;Oligosaccharides;pathogen;pathogenic bacteria;Peptides;Peptidoglycan;polyclonal antibody;Polysaccharides;Positioning Attribute;preclinical study;Preparation;Productivity;programs;Publishing;Qualifying;Reporting;Research Personnel;Resistance to infection;resistant strain;Science;Serotyping;small molecule;Staphylococcus aureus;Structural Biologist;structural biology;Structure;Surface;T-Lymphocyte;Therapeutic;United States National Institutes of Health;vaccine effectiveness;vaccine immunogenicity;Vaccines;Variant;web site;World Health Organization

PROJECT_TITLE: Multidimensional development of high-affinity anti-glycan antibodies to fight deadly bacterial infections


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: This PPG will develop a mechanistic understanding of how the TIGIT/CD155 and PD-1/PD-L1 coinhibitory pathways interact with each other to maintain tissue tolerance in the clinical context of autoimmune diseases and cancer. This new knowledge will further the development of novel strategies for manipulating coinhibitory pathways to stimulate or inhibit immune responses in specific diseases that can translate to novel human immunotherapies. Specifically, the translational goals are to develop novel strategies to treat autoimmunity and cancer, and to limit tissue inflammation associated with adverse autoimmune events observed with cancer immunotherapy.

PI_NAMEs: HAFLER, DAVID A. (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Address;Adverse event;Affect;Agonist;anti-PD-1;anti-PD-L1;Autoimmune;Autoimmune Diseases;Autoimmunity;autoreactive T cell;Binding;Blood;brain tissue;cancer immunotherapy;Cell Physiology;cell type;Cells;Central Nervous System Diseases;Chronic;Clinical;CNS autoimmune disease;CNS autoimmunity;Data;data integration;Defect;design;Development;Disease;Effector Cell;effector T cell;Equilibrium;Event;Experimental Autoimmune Encephalomyelitis;Experimental Models;experimental study;FOXP3 gene;Frequencies;Functional disorder;Genes;Glioblastoma;Goals;Grant;Human;Immune;Immune Evasion;Immune response;immune-related adverse events;immunopathology;Immunotherapy;In Vitro;in vivo;Inflammation;Inflammatory;interest;Investigation;Knowledge;Ligands;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Modeling;Molecular;Monoclonal Antibodies;mouse model;Mouse Strains;multiple omics;Mus;Myeloid Cells;Myeloproliferative disease;neoplastic cell;neuroinflammation;Neurologic;novel;novel strategies;novel therapeutic intervention;Pathogenicity;Pathway interactions;Patients;PD-1 blockade;PD-1/PD-L1;PDL1 pathway;peripheral tolerance;Predisposition;Process;Productivity;programmed cell death ligand 1;programmed cell death protein 1;Publications;Regulatory T-Lymphocyte;Research Personnel;Role;Series;Severities;Signal Transduction;success;synergism;T cell response;T-Cell Activation;T-Lymphocyte;Technology;Testing;Therapeutic;Therapeutic Intervention;therapy design;Tissues;Translating;translational goal;tumor;tumorigenesis;Work

PROJECT_TITLE: Costimulatory Mechanisms of Autoimmunity


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PROJECT_TERMS: Administrator;Affinity;Annual Reports;Antibiotic Resistance;Antibodies;Award;Bacterial Infections;Charge;Collaborations;Collection;combat;Communication;Communities;Contracts;design;Development;Dimensions;Electronic Mail;experience;Feedback;fighting;General Population;Goals;Grant;Individual;Institution;Medical;meetings;member;National Institute of Allergy and Infectious Disease;Participant;Polysaccharides;Principal Investigator;programs;Protocols documentation;Reporting;Research;Research Personnel;Resources;Review Committee;Role;Structure;Telephone;United States National Institutes of Health;Update;Veterans;virtual;web site;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Autoimmune Disease

PROJECT_TERMS: Address;Autoimmunity;Communication;Consultations;cost effective;Data;data sharing;Data Storage and Retrieval;Decision Making;Ensure;Goals;Institution;Intellectual Property;Monitor;program dissemination;programs;Publications;Research;Research Project Grants;Resources;Technology


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The goal of this application is to accomplish a comprehensive analysis of the transcriptional and immune function of PADI4, which my data indicate is a key target gene for p53-mediated tumor suppression. I expect the proposed research to impact our understanding of PADI4 and histone citrullination in cancer, as histone citrullination is among the most understudied histone post-translational modifications. Understanding the role of PADI4 in tumor suppression and the p53 pathway will provide crucial insight into cancer risk and could point toward novel therapeutic targets in cancer.

PI_NAMEs: INDEGLIA, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Address;Agar;Antigens;Arginine;ATAC-seq;Biological Assay;cancer cell;cancer risk;cancer therapy;Cell Line;Cells;Chromatin;chromatin immunoprecipitation;Citrulline;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;Complex;Data;data integration;Defect;druggable target;Epigenetic Process;experimental study;Genes;Genetic study;Genetic Transcription;genotoxicity;Goals;histone modification;Histones;Human;Immune;immune activation;immune function;Immunocompetent;Immunocompromised Host;Impairment;Individual;Injury;insight;Knockout Mice;Knowledge;Ligation;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;Methylation;Mus;Mutate;Mutation;neoplastic cell;new therapeutic target;novel;novel therapeutics;Oncogenes;Oncogenic;overexpression;Pathway interactions;Pharmaceutical Preparations;Play;Population;Post-Translational Protein Processing;Process;Proliferating;Property;Protein-arginine deiminase;Proteins;recruit;Regulation;Reporting;Research;response;Role;small molecule inhibitor;Testing;Tetracyclines;The Cancer Genome Atlas;Time;Tissues;TP53 gene;Transactivation;transcription factor;Transcriptional Activation;transcriptome sequencing;tumor;Tumor Cell Line;tumor growth;Tumor Suppression;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumor xenograft;unnatural amino acids;Variant

PROJECT_TITLE: Role of PADI4 as a key epigenetic regulator of the p53 pathway and tumor suppression


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: DENTISTRY

PHR: Acute myeloid leukemia (AML) has been proposed to interact with specialized niches within the bone marrow microenvironment as a means to resist chemotherapy. The goal of this work is to to determine the single-cell composition of human bone marrow, ascertain whether residual AML cells reside in a protective endosteal niche, and find if transcriptional changes incurred by AML cells over the course of therapy mediate their interaction with specific niche cell populations. Collectively, this work will improve our understanding of the microenvironmental contribution to AML chemoresistance, which will help nominate novel therapies that target sources of protection for AML within the bone marrow niche.

PI_NAMEs: BANDYOPADHYAY, SHOVIK  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Ablation;Acute leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;Antibodies;Biological Assay;Biopsy;Bone Marrow;Bone Marrow Aspiration;Bone marrow biopsy;Bone Marrow Cells;Bone Marrow Neoplasms;c-myc Genes;Cell Communication;cell type;Cells;Cellularity;Chemoresistance;Chemosensitization;chemotherapy;Clinical;clinical remission;Coculture Techniques;Complement;CRISPR/Cas technology;CXCR4 gene;Cytarabine;Cytotoxic Chemotherapy;Detection;Diagnosis;Diagnostic;Disease;Epitopes;Genetic;Genetic Transcription;Goals;Hematologic Neoplasms;Hematopoiesis;hematopoietic stem cell quiescence;Hematopoietic stem cells;Human;human tissue;Image;immunodeficiency;Immunophenotyping;improved;In Situ;indexing;Knock-out;leukemia;Leukemic Cell;Ligands;Marrow;Measures;Mediating;Mediator;Membrane Proteins;Methods;Microanatomy;Morphology;mouse model;multiplexed imaging;Mus;mutant;Mutation;neoplastic cell;new therapeutic target;novel therapeutics;NPM1 gene;overexpression;patient derived xenograft model;Patient Selection;Patients;Physiology;Population;Prognosis;Prognostic Factor;Proliferation Marker;Proteins;receptor;Relapse;relapse risk;Residual Neoplasm;Residual state;Resistance;Resolution;response;Sampling;self-renewal;single-cell RNA sequencing;Source;standard of care;stem cell niche;Stromal Cell-Derived Factor 1;Stromal Cells;Survival Rate;System;targeted treatment;therapy development;Time;Tissues;transcriptomics;treatment response;tumor;Visualization;Work

PROJECT_TITLE: Determining the Microenvironmental Contribution to Acute Myeloid Leukemia Chemoresistance


PI_NAMEs: SHARPE, ARLENE H. (contact)

PROJECT_TERMS: Address;Adhesions;Agonist;anti-PD-1;Autoimmunity;Backcrossings;Bone Marrow;Breeding;Candidate Disease Gene;CD8-Positive T-Lymphocytes;cell growth;Cell Physiology;cell type;Cells;Chimera organism;Collection;combinatorial;Congenic Strain;Cre driver;CRISPR/Cas technology;Cryopreservation;Cytoplasm;Data;data integration;Data Set;Dendritic Cells;Development;differential expression;effector T cell;Engineering;Equilibrium;FOXM1 gene;Gene Deletion;Generations;Genes;Genetic;Genetic Transcription;Genomics;Goals;Guide RNA;Hematopoietic;Hematopoietic System;Immune;Immune response;immunoregulation;In Vitro;in vivo;Inbreeding;Individual;innovation;interest;ITIM;Knock-out;knockout gene;Knockout Mice;Lentivirus;LoxP-flanked allele;Lymphocyte;Mediating;Mediator;Mouse Strains;multiple omics;Mus;mutant;Mutant Strains Mice;Mutation;Myeloid Cells;neoplastic cell;novel;PD-1/PD-L1;PDL1 pathway;phosphoproteomics;preservation;programmed cell death ligand 1;programmed cell death protein 1;Proteomics;receptor binding;Regulatory T-Lymphocyte;repository;Research Personnel;Role;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;System;T-Lymphocyte;Technology;Time;Tissues;transcriptomics;Transgenic Organisms;Work

PROJECT_TITLE: Core B Gene Perturbation Core


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Sexually Transmitted Infections

PI_NAMEs: HORSWILL, ALEXANDER R (contact)

PROJECT_TERMS: Address;Affinity;Animal Model;Antibiotic Resistance;Antibiotic susceptibility;Antibodies;Antibody Specificity;Bacterial Antibiotic Resistance;Bacterial Infections;Bacteriology;Binding;Biological Assay;burden of illness;carbapenem-resistant Enterobacteriaceae;Clinical;Community Healthcare;Complement;Complement 3b;Death Rate;Deposition;Development;Dimensions;disorder control;Drug-resistant Neisseria Gonorrhoeae;Exhibits;fighting;Financial Hardship;Goals;Growth;health care settings;Human;Immune;Immune response;Immune system;Immunotherapy;Infectious Agent;Infectious Skin Diseases;Invaded;Klebsiella pneumoniae;Knock-out;Length of Stay;Link;Mediating;Membrane Proteins;methicillin resistant Staphylococcus aureus;Microbial Antibiotic Resistance;microbial disease;microorganism;mouse model;mutant;Neisseria gonorrhoeae;neutrophil;Outcome;pathogen;pathogenic bacteria;Peptide Hydrolases;Peptidoglycan;Phagocytosis;Polysaccharides;Protein Glycosylation;Proteins;Reporting;Resistance;resistance mechanism;response;Role;Series;Serum;Skin;Staphylococcus aureus;Staphylococcus aureus infection;Surface;Teichoic Acids;Testing;Validation;World Health Organization

PROJECT_TITLE: Bacteriology Core


PROJECT_TERMS: Affinity;Agreement;Animals;Anti-Bacterial Agents;Antibodies;antibody engineering;Antibody Formation;Antigens;Archives;B-Lymphocytes;Bacterial Infections;Bacterial Proteins;Bacteriology;Binding;Cells;Charge;Chinese Hamster Ovary Cell;Chromatography;Complement;Computers;Crystallization;Deposition;Development;Dimensions;DNA;Electronics;Enzyme-Linked Immunosorbent Assay;Enzymes;Excision;experience;experimental study;Fab Immunoglobulins;Fc Immunoglobulins;fighting;Funding;Grant;Half-Life;Heart;Hemorrhage;Human;Immunization;Immunize;Immunoglobulin A;Immunoglobulin Fragments;Immunoglobulin M;Insecta;Institution;instrumentation;interest;Knowledge;Laboratories;Length;Light;meetings;member;Modification;Monoclonal Antibodies;Mus;Mutate;National Institute of Allergy and Infectious Disease;Papain;polyclonal antibody;Polysaccharides;Positioning Attribute;Production;programs;Proteins;PTPRC gene;Quality Control;Reagent;Recombinant Proteins;Recombinants;repository;Resources;Robot;Role;Route;Running;single cell sequencing;success;Surface Plasmon Resonance;System;Techniques;Time;Update;web site;Work

PROJECT_TITLE: Antibody Core


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Arteriovenous fistulas (AVFs) are the preferred type of vascular access for hemodialysis, and surgical creation of AVFs is the current gold standard, yet many surgical AVFs fail to mature for use. Endovascular AVF creation, a novel percutaneous (non-surgical) method to create a vascular access, was recently approved by the FDA. The goal of the proposed research is to establish a solid foundation for the design and conduct of a randomized clinical trial to compare the clinical and economic impact of endovascular AVFs and surgical AVFs.

PI_NAMEs: AL-BALAS, ALIAN  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Academic Medical Centers;Address;Age;Alabama;Arteries;Arteriovenous fistula;Award;Bacteremia;Blood flow;Blood Vessels;Cannulations;career development;Catheters;Clinical;Clinical Investigator;Clinical Research;Clinical Trials Design;cohort;Cohort Studies;cost;Country;Data;Databases;design;diabetic;Dialysis procedure;Diameter;economic impact;Eligibility Determination;Ensure;experience;FDA approved;Foundations;Frequencies;Functional disorder;Funding;Future;Goals;head-to-head comparison;Hemodialysis;Hospitalization;improved;Individual;Information Systems;Institution;Intervention;Investigation;K-Series Research Career Programs;Kidney;Legal patent;Mentors;Methods;novel;Operative Surgical Procedures;Outcome;Outcome Study;patient oriented;Patient Recruitments;patient retention;patient subsets;Patients;Physiological;Pilot Projects;Positioning Attribute;Postoperative Period;primary endpoint;Procedures;prospective;Public Health;Race;Randomized;randomized, clinical trials;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Schedule;Science;secondary endpoint;sex;skills;Solid;Surrogate Markers;Techniques;Time;Training;trial comparing;ultrasound;United States;Universities;Veins;Venous

PROJECT_TITLE: Endovascular vs. Surgical Arteriovenous Fistula Outcomes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: ZHANG, LE  (contact)

PROJECT_TERMS: Animal Model;ATAC-seq;Autoimmune Diseases;Autoimmunity;autoreactive T cell;Bar Codes;Biological Assay;Biological Process;Brain;Cell Nucleus;Cell Physiology;cell type;Cells;Chromatin;Clinical;Computational Biology;computing resources;Data;data integration;Data Set;Detection;Disease;disease model;Epigenetic Process;epigenomics;Experimental Models;Foundations;Freezing;Generations;Genes;Genetic Transcription;Genomics;Glioblastoma;Goals;Grant;Health;Human;human disease;human model;human tissue;Image;Immune;immune function;Immune response;Immune signaling;Immunity;Immunobiology;Immunologics;Inflammasome;Inflammation;insight;Investigation;Joints;Knockout Mice;Ligands;Malignant Neoplasms;Maps;Methods;Microfluidics;Microglia;Modeling;Molecular Profiling;Molecular Target;Morphology;mouse model;multiple omics;Multiple Sclerosis;multiple sclerosis patient;Mus;Myelogenous;Myeloid Cells;neuroinflammation;new technology;new therapeutic target;novel;Outcome;Pathway Analysis;Pathway interactions;PD-1/PD-L1;Preparation;Process;Program Research Project Grants;programmed cell death protein 1;Proteomics;receptor;Regulatory T-Lymphocyte;Reproducibility;Research;Research Personnel;Research Project Grants;Resolution;Role;Sampling;Services;Signal Pathway;Signal Transduction;single cell analysis;single cell ATAC-seq;single nucleus RNA-sequencing;single-cell RNA sequencing;Slide;Structure;Surface;System;T-Lymphocyte;Technology;therapeutic target;Therapeutic Uses;tissue fixing;tissue preparation;Tissues;tool;transcriptomic profiling;transcriptomics;Tumor-Infiltrating Lymphocytes;Universities;Work

PROJECT_TITLE: Core C: Subtractive Single Nucleus Seq and Spatial Multi-omics Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Narrative It is well established that Ewing sarcoma is driven by a fusion oncogene, EWSR1-FLI1, however the biology of this oncogene is poorly understood. In our prior work we identified that EWSR1-FLI1 dysregulates a fundamental process, transcription, causing an increase in R-loops. While R-loops serve normal functions, high levels of R-loops are considered deleterious and are often associated with genome instability and a loss of cellular fitness. The mechanism of how Ewing sarcoma is able to maintain high levels of R-loops without genomic instability is not known. If we can determine this mechanism, then we should be able to specifically target it as an alternate therapy for the treatment of Ewing sarcoma.

PI_NAMEs: BISHOP, ALEXANDER JAMES (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Acute;Alternative Splicing;Binding;Biological Assay;Biology;BRCA1 gene;cDNA Expression;Cell Cycle;Cell Cycle Progression;Cell Physiology;cell type;Cells;Chemicals;Childhood;Chimeric Proteins;ChIP-seq;comparison control;Data;Data Analyses;Defect;DNA Damage;DNA Repair;efficacy testing;Ewings sarcoma;EWSR1 gene;fitness;FLI1 gene;Genes;Genetic;Genetic Transcription;Genome;Genome Stability;genome-wide;Genomic Instability;Genomics;global run on sequencing;Goals;Growth;helicase;Impairment;in vivo;inhibitor;insight;interest;Intervention;Lesion;Link;Location;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Modeling;Molecular;Monitor;Nature;Oncogenes;Paper;Pathologic;Pathway interactions;Pharmacologic Substance;Phenotype;Physiological;prevent;Process;programs;protein function;Proteins;Publishing;replication stress;Reporter;Reporting;Resolution;response;RNA;RNA helicase A;RNA Interference;RNA metabolism;RNA Polymerase II;RNA Processing;RNA Splicing;Role;SETX gene;single cell sequencing;Site;Small Interfering RNA;stem cells;targeted treatment;Techniques;Testing;Text;Therapeutic;Time;Toxic effect;Transcription Process;transcriptome sequencing;tumor;tumor growth;tumor xenograft;Uridine;Work;young adult

PROJECT_TITLE: Dysregulated transcription processes in Ewing sarcoma

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Immunotherapy

PI_NAMEs: KUCHROO, VIJAY K. (contact)

PROJECT_TERMS: Address;Affect;Affinity;Antigen-Presenting Cells;Autoimmune;Autoimmunity;B-Lymphocytes;Back;Binding;cancer cell;CD28 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;cell growth;Cell Physiology;Cell secretion;cell type;Cells;Chronic;Chronic Disease;CTLA4 gene;cytokine;Data;Dendritic Cells;effector T cell;exhaust;Exhibits;Experimental Autoimmune Encephalomyelitis;experimental study;FOXP3 gene;Genomics;Grant;Growth;Human;Human poliovirus;In Vitro;in vivo;Inflammatory;Interferon Type II;Interleukin-10;Interleukin-12;Knockout Mice;Ligands;Ligation;Malignant Neoplasms;Modeling;Molecular;multiple omics;Mus;Myeloid Cells;Natural Killer Cells;neoplastic cell;novel;Oncogenic;Pathway interactions;PD-1 pathway;Phenotype;phosphoproteomics;Play;Population;Production;programmed cell death protein 1;programs;Proliferating;Proteomics;receptor;Regulatory T-Lymphocyte;Role;Signal Transduction;stemness;T cell regulation;T cell response;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Technology;Tissues;transcriptomics;tumor;Tumor Antigens;tumor growth;Tumor Immunity;Tumor Promotion;Tumor Stem Cells;tumorigenesis;Virus Diseases;Virus Receptors;Work

PROJECT_TITLE: Project 1: Bidirectional interactions between TIGIT and CD155 in regulating tissue tolerance


PI_NAMEs: WILSON, IAN A (contact)

PROJECT_TERMS: Acceleration;Affinity;Anti-Bacterial Agents;Antibodies;antibody engineering;Antibody Specificity;Antigens;B-Lymphocytes;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;Binding;Biochemical;biophysical properties;Biophysics;CD4 Positive T Lymphocytes;Charge;Chemicals;Complex;design;Development;Dimensions;efficacy testing;Engineering;Fab Immunoglobulins;fighting;global health;Glycopeptides;Goals;Grant;Helper-Inducer T-Lymphocyte;Histocompatibility Antigens Class II;Immune response;Immune system;Immunization;Immunologics;Immunotherapy;improved;instrumentation;Klebsiella pneumoniae;Length;Life;Link;MHC Class II Genes;Mission;Modeling;Modification;Neisseria gonorrhoeae;novel;Organism;Peptides;Peptidoglycan;Polysaccharides;rational design;response;Site;Staphylococcus aureus;structural biology;Structure;Surface;T cell response;T-Lymphocyte;Teichoic Acids;Therapeutic;Therapeutic antibodies;tool;Vaccines;Virus-like particle;X-Ray Crystallography

PROJECT_TITLE: Structural Biology Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative TRPM4 and TRPM5 are Ca2+-activated nonselective monovalent cation channels whose genetic mutations lead to multiple severe human diseases. Our project uses a multidisciplinary approach to investigate the structural mechanism underlying their activation and inhibition processes, aiming to reveal fundamental mechanisms to guide clinical interventions.

PI_NAMEs: DU, JUAN ;YAROV-YAROVOY, VLADIMIR M;ZHENG, JIE  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Address;Amino Acid Motifs;Binding;Binding Sites;Brugada syndrome;Calcium;Cardiac;Cardiovascular system;Cations;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Cryoelectron Microscopy;Data;Disease;disease phenotype;DNA Sequence Alteration;Exhibits;fluorescence imaging;Fluorometry;gain of function;gain of function mutation;Human;human disease;Immune system;Inherited;inhibitor;interdisciplinary approach;Intervention;Ion Channel;Knock-in Mouse;Knowledge;Lead;Link;Membrane;Membrane Potentials;Methods;Modeling;Molecular;Molecular Conformation;Monitor;Monovalent Cations;mouse model;mutant;Mutation;Nervous System;novel;Organ;patch clamp;Permeability;Pharmacologic Substance;Phenotype;Physiological;Play;Process;Property;Role;Side;Signal Transduction;Site;Skin;skin disorder;Structure;Syndrome;Testing;Tissues;TRPM5 gene;voltage

PROJECT_TITLE: Activation and Inhibition Mechanisms of Calcium-Activated Nonselective Cation Channels

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Biotechnology;Hematology;Immunotherapy;Kidney Disease;Organ Transplantation;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE We have achieved, in nonhuman primates and initial clinical trials, induction of transient hematopoietic chimerism and long-term I.S. free renal allograft survival, following combined kidney and BM, MHC mismatched transplantation. The proposed research studies will evaluate novel conditioning modalities using Bcl-2 and Mcl-1 inhibitors in place of irradiation or chemotherapy. We anticipate this will provide safer and more effective recipient conditioning, which will make this tolerance strategy available to many more transplant recipients, including those receiving organs from deceased donors. Our NHP model has proved to provide strong correlations with subsequently observed outcomes in humans. Thus we anticipate the results of these studies will be directly applicable to clinical trials.

PI_NAMEs: KAWAI, TATSUO  (contact)

PROGRAM_OFFICER_NAME: SHAW, JULIA M

PROJECT_TERMS: Achievement;Address;Allograft Tolerance;Allografting;Antigens;Apoptosis;Apoptotic;BCL2 gene;Bone Marrow;Bone Marrow Transplantation;Cells;chemotherapy;Chemotherapy and/or radiation;Chimerism;Clinical;clinical application;Clinical Trials;Clonal Expansion;Clone Cells;conditioning;Cryopreservation;Data;Disease;Dual-role transvestism;experimental study;extracellular vesicles;Family suidae;FDA approved;Future;Goals;Grant;Hematopoietic;Hematopoietic stem cells;HLA Antigens;Human;Immune;Immunologics;Immunosuppression;Immunosuppressive Agents;improved;In Vitro;in vivo;Infection;inhibitor;irradiation;Kidney;kidney allograft;Kidney Transplantation;Leukopenia;Living Donors;living kidney donor;Macrophage;Maintenance;Malignant Neoplasms;MCL1 gene;Metabolic Diseases;Methods;Modality;Modeling;Monoclonal Antibodies;monocyte;Morbidity - disease rate;mortality;Mus;Myelosuppression;Neutropenia;nonhuman primate;novel;novel strategies;Organ;Organ Transplantation;Outcome;Pathway interactions;Pharmaceutical Preparations;post-transplant;preclinical study;Process;Protocols documentation;Radiation;Regimen;Reporting;Reproducibility;research study;Role;standard of care;T-Lymphocyte;Testing;Therapeutic;Thrombocytopenia;Time;TNFSF5 gene;Transplant Recipients;Transplantation

PROJECT_TITLE: Bcl-2 and Mcl-1 inhibition for induction of hematopoietic chimerism and renal allograft tolerance without myelosuppression in nonhuman primates

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases

PI_NAMEs: SAVAGE, PAUL B (contact)

PROJECT_TERMS: adaptive immunity;Adjuvant;Affinity;Antibiotics;Antibodies;Antibody Affinity;Antigens;Aspartate;B-Lymphocytes;Bacteria;Bacterial Infections;Binding;Carbohydrates;Cell Wall;chemical synthesis;Clupeidae;Companions;Complement;Complement Activation;Dangerousness;design;Development;Dimensions;Disease Outbreaks;Drug resistance;drug resistant bacteria;Enzymes;Epitopes;Family;fighting;Fimbriae Proteins;Generations;glycosylation;Growth;Health;Hospitals;Human;human pathogen;Hypertension;Immune Evasion;Immune response;Immune system;Immunity;Immunoglobulin Class Switching;Immunoglobulin M;Individual;Infection;Infectious Agent;Instruction;Investigation;Klebsiella Infections;Klebsiella pneumoniae;Label;Learning;Link;Methods;nanomolar;Natural Immunity;Nature;Neisseria gonorrhoeae;novel therapeutics;Oligosaccharides;Organism;Outcomes Research;pathogen;pathogenic bacteria;Peptides;Performance;Phagocytosis;Polymers;Polysaccharides;Polyvalence;Preparation;pressure;Process;Production;Reagent;Resistance;resistant strain;response;ribulose;Scientist;Serine;Serotyping;Staphylococcus aureus;Structure;sugar;System;T-Cell Receptor;T-Lymphocyte;Therapeutic Uses;Time;Trisaccharides;United States National Institutes of Health;Vaccines;Virus;Virus-like particle;Work

PROJECT_TITLE: Carbohydrate epitope discovery via chemical synthesis


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Comparative Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Colorectal cancer (CRC) remains a leading cause of cancer death in the United States. The objective of the Rural Community Support for Colonoscopy project is to test the effectiveness and study the implementation of a patient navigation program for increasing colonoscopy completion in rural populations with a positive fecal immunochemical test (FIT) result. The findings from this study will advance our knowledge of the effectiveness of patient navigation in this patient population and will guide future implementation and dissemination of the program.

PI_NAMEs: COLE, ALLISON  (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: acceptability and feasibility;Address;Adult;aged;Cancer Burden;cancer diagnosis;Cancer Etiology;cancer therapy;cancer type;care coordination;Caring;Cessation of life;Child Care;Clinic;Clinical;Colonoscopy;Colorectal Cancer;colorectal cancer prevention;colorectal cancer screening;Communities;community advisory board;Community Health;community organizations;compare effectiveness;County;Creativeness;Data;Data Collection;Detection;Diagnosis;Early Diagnosis;Early Intervention;Education;effective intervention;Effectiveness;effectiveness testing;effectiveness/implementation design;effectiveness/implementation study;effectiveness/implementation trial;Enrollment;Evaluation;evidence base;Excision;Face;Failure;Federally Qualified Health Center;follow-up;Fright;future implementation;Geography;Health system;high risk;Hybrids;implementation evaluation;implementation outcomes;improved;improved outcome;insight;Integrated Health Care Systems;Intervention;Interview;Knowledge;Low income;Low Income Population;mortality;motivational enhancement therapy;Needs Assessment;Observational Study;Outcome;Pamphlets;Participant;participant enrollment;Pathway interactions;patient navigation;patient navigator;patient population;Patients;pilot test;Population;Precancerous Polyp;Primary Care;primary care clinic;procedure cost;Procedures;Process;program dissemination;Program Sustainability;programs;Provider;Qualitative Methods;Randomized;Randomized, Controlled Trials;Recommendation;Resources;Risk;Role;Rural;rural area;Rural Community;rural counties;rural disparities;Rural Health;rural patients;Rural Population;Schedule;screening;socioeconomics;Test Result;Testing;Time;Transportation;Travel;United States;United States Preventative Services Task Force;Washington;Work

PROJECT_TITLE: Rural Community Support for Colonoscopy


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Cancer

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative VCPIP1, an anti-tumor target and a deubiquitinase in the DUB OTU family, is abundant in many cancers and can be characterized using structural biology methods. Using structure-based drug discovery (SBDD) methods, I propose to utilize the unknown structure of VCPIP1 in complex with VCP to help optimize inhibitor activity within the drug discovery process. I expect this to make a profound impact in therapeutics and human health.

PI_NAMEs: SHAH, BINITA  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: 3-Dimensional;Affinity;anti-cancer;ATP phosphohydrolase;Binding;Binding Sites;Biochemical;Biological Assay;Biology;Body of uterus;Bortezomib;Breast;Cancer Biology;Carcinoma;Caspase;Cells;Chemicals;Classification;Client;clinical development;Complex;computerized data processing;Computing Methodologies;Coupled;crosslink;Cryoelectron Microscopy;Cysteine;Data;Data Collection;density;Deubiquitinating Enzyme;Deubiquitination;Development;Disease;Docking;Drug Design;drug discovery;Drug Targeting;Endometrial Carcinoma;Endoplasmic Reticulum;Engineering;Enzymatic Biochemistry;enzyme activity;Enzyme Inhibitor Drugs;Enzyme Kinetics;Enzymes;Experimental Designs;Family;FDA approved;Fluorescence;Glues;Golgi Apparatus;Health;High Prevalence;Homeostasis;Human;Immunoprecipitation;improved;In Vitro;inhibitor;insight;Knowledge;Lead;lenalidomide;Ligase;Location;Malignant Neoplasms;Mammalian Cell;Maps;Mass Spectrum Analysis;Mediating;member;Methods;Mitosis;Modeling;Molecular;Monitor;multicatalytic endopeptidase complex;Mutagenesis;mutant;Mutate;Oncoproteins;ovarian neoplasm;Pharmaceutical Preparations;Play;Precision therapeutics;prevent;Process;Proteasome Inhibitor;protein complex;protein structure function;Proteins;proteostasis;Reaction;reconstitution;reconstruction;Regulation;Resolution;Role;Sampling;scaffold;Signal Transduction;Site;Specificity;stoichiometry;structural biology;Structure;Substrate Interaction;System;targeted agent;Testing;Therapeutic;therapeutic target;Titan;tumor;Ubiquitin;ubiquitin isopeptidase;Ubiquitin-Activating Enzymes;Ubiquitin-Conjugating Enzymes;ubiquitin-protein ligase;Ubiquitination;valosin-containing protein;X-Ray Crystallography

PROJECT_TITLE: Structural and biochemical characterization of VCPIP1 and VCP complex


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

PROJECT_TERMS: Affect;Agonist;anti-PD-1;anti-PD-L1;Antibodies;Autoimmune Diseases;Autoimmunity;Binding;Blood;cancer immunotherapy;CD8-Positive T-Lymphocytes;Cell Physiology;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;CNS autoimmunity;conditional knockout;Cytometry;Cytoplasmic Tail;cytotoxicity;Data;Defect;design;Effector Cell;effector T cell;Equilibrium;Experimental Autoimmune Encephalomyelitis;FOXP3 gene;Frequencies;Functional disorder;Genes;genetic approach;Genetic Transcription;Glioma;Goals;Heterogeneity;high dimensionality;Immune;immune-related adverse events;In Vitro;Inflammation;insight;Interleukin-10;Knockout Mice;Malignant Glioma;Malignant Neoplasms;Mediating;Mediator;migration;Modeling;Molecular;Monoclonal Antibodies;multiple omics;multiple sclerosis patient;Mus;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Pathogenicity;Pathway interactions;PD-1 blockade;PD-1/PD-L1;PDL1 pathway;Peripheral;Play;Production;Program Research Project Grants;programmed cell death ligand 1;programmed cell death protein 1;programs;receptor;Regulatory T-Lymphocyte;Research Personnel;Role;Severities;Signal Transduction;single-cell RNA sequencing;Spleen;T cell receptor repertoire sequencing;T-Cell Activation;T-Lymphocyte;Testing;therapeutic target;Tissues;tool;transcriptomics;tumor;tumor growth;Tumor Immunity;Work

PROJECT_TITLE: Project 2: Elucidating how TIGIT agonists regulate CNS autoimmunity exacerbated by PD-1 blockade


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Uncontrolled hypertension has been associated with numerous effects on health resulting in a poor quality of life or even a fatal heart attack or stroke, $131 billions of dollars in national healthcare expenditures and worse outcomes that are most severe among the poor, disadvantaged, and racial and ethnic minorities such as refugees and immigrants. Since nothing is known about how refugees with hypertension manage their condition at home, we will look into barriers to that and feasibility of interventions to self-manage their hypertension as a critical step to the adaptation, implementation, and evaluation of evidence-based interventions that empower refugees to engage in self-managing their cardiovascular disease risk. In addition, the proposed project will allow the candidate to master a complex set of research skills in the development of novel hypertension interventions, and develop topical expertise required to fully characterize hypertension management challenges and intervene to reduce cardiovascular disease risk by researching special patient populations that are understudied and suffer disproportionately from hypertension, generating knowledge that can be applied to many other patients.

PI_NAMEs: AL-ROUSAN, TALA  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Age;Anti-Hypertensive Agents;Awareness;Biometry;Blood Pressure;blood pressure control;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career;Caring;Clinical;Clinical Trials;Communities;community intervention;Complex;cost effective;Country;County;Data;design;Deterioration;Development;Diagnosis;Disadvantaged minority;disease disparity;Disparity;Educational workshop;effectiveness research;efficacy evaluation;empowerment;Epidemiology;epidemiology study;ethnic minority;Evaluation;evidence base;Evidence based intervention;experience;Feasibility Studies;Foundations;Future;Gender;Goals;Health;health care availability;health disparity;Health Expenditures;health inequalities;Health Knowledge Attitudes Practice;health literacy;Home;Home Blood Pressure Monitoring;Hypertension;hypertension control;Immigrant;implementation research;improved;Instruction;Intervention;Intervention Studies;Iraq;Knowledge;Knowledge acquisition;Language;Learning;Literature;Location;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Migrant;migration;Minority Groups;Modeling;Monitor;multilevel analysis;Myocardial Infarction;National Heart, Lung, and Blood Institute;novel;Outcome;Outcome Measure;Pathway Analysis;patient oriented research;patient population;Patients;perceived discrimination;Pharmaceutical Preparations;Population;Positioning Attribute;preservation;Prevention;Protocols documentation;Provider;Quality of life;racial minority;randomized, clinical trials;Refugee Camp;Refugees;Religion;Research;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;responsible research conduct;Rest;satisfaction;Science;Self Management;Self Medication;skill acquisition;skills;social determinants;social health determinants;Social Network;Somalia;Specific qualifier value;Stress;Stroke;Structure;success;theories;Time;Titrations;tool;Training;Training Activity;Treatment Cost;Treatment Efficacy;Trust;Vulnerable Populations;Work

PROJECT_TITLE: Hypertension Self-management in Refugees Living in San Diego


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DALLAS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: The Chook Laboratory aims to understand mechanisms of how Karyopherin- proteins recognize cargos and other binding partners. We will discover new cargos and classes of NLSs for understudied importins and study Kap chaperone functions. We will study cargo interactions for exportins CRM1 and Msn5.

PI_NAMEs: CHOOK, YUH MIN  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Affect;Apoptosis;Base Sequence;Binding;Biochemical;cancer cell;Cell Physiology;comparative;Consensus;Cytoplasm;design;Disease;Exportins;Health;Histone H2A;Histones;Human;Importins;improved;inhibitor;Karyopherins;Laboratories;Malignant Neoplasms;Maps;Mediating;Molecular Chaperones;mRNA Export;Mutation;Nuclear;Nuclear Export;Nuclear Import;nucleocytoplasmic transport;Nucleosomes;Oncogenic;Phosphorylation;prevent;Proteins;response;RNA-Binding Proteins;Saccharomyces cerevisiae;Signal Transduction;small molecule inhibitor;Specificity;Structure;System;transportin SR

PROJECT_TITLE: Biochemical and cellular functions of Karyopherins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


PHR: PROJECT NARRATIVE Co-occurring and mutually exclusive patterns of cancer-promoting mutations reveal context-dependent effects of driver alterations in tumorigenesis. This project seeks to investigate the paradoxical effects of the frequently inactivated gene SETD2 in KRAS- and EGFR-driven lung adenocarcinoma. Understanding the mechanism of SETD2's relationship with each oncogene will identify targetable therapeutic vulnerabilities in human cancer.

PI_NAMEs: DOERIG, KATHERINE  (contact)

PROJECT_TERMS: Acceleration;antagonist;Benchmarking;BRAF gene;cancer cell;Cancer Etiology;cancer genome;cancer therapy;cancer type;Cell Death;Cell Line;Cell Proliferation;Conflict (Psychology);Data;Development;Disease;driver mutation;Epidermal Growth Factor Receptor;fitness;FRAP1 gene;Genes;Genetic;Genetic Epistasis;genome sequencing;Genotype;Growth;histone methyltransferase;Human;improved;Individual;insight;KRAS oncogenesis;KRAS2 gene;Laboratories;Lung Adenocarcinoma;Maintenance;Malignant Neoplasms;MAP Kinase Gene;Modeling;mouse model;Mus;Mutate;Mutation;neoplastic cell;new therapeutic target;Oncogenes;Oncogenic;outcome disparities;Pathway interactions;Patients;Pattern;PIK3CG gene;prevent;Protein Biosynthesis;Proto-Oncogene Proteins c-akt;Role;Signal Transduction;STK11 gene;synergism;Testing;Therapeutic Intervention;Therapeutically Targetable;tumor;Tumor Burden;Tumor Cell Line;tumor growth;Tumor Promotion;Tumor Suppressor Proteins;Tumor-Derived;tumorigenesis;tumorigenic;Work

PROJECT_TITLE: Paradoxical Effects of SETD2 Inactivation in EGFR- and KRAS-driven Lung Adenocarcinoma


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Neurosciences;Rehabilitation;Stroke

ORG_CITY: Nashville

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE  Aphasia is a common and debilitating communication disorder caused by damage to the language regions of the brain, most often from stroke. Although impairments in the production of naturalistic language, such as conversational speech, are ubiquitous in aphasia and of high priority for rehabilitation, there remains a lack of understanding about which brain regions are associated with impairment and how performance improves over time. The proposed project will address these limitations in the current literature by leveraging a novel measure and applying it to a large and ongoing longitudinal study, with the goal of building an explanatory brain- behavior framework that advances our understanding of naturalistic language production in aphasia and meaningfully informs clinical management practices.

PI_NAMEs: CASILIO, MARIANNE E (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acute;Address;advanced analytics;Agrammatism;Aphasia;aphasia recovery;Area;Auditory;Behavioral;Behavioral Model;Benchmarking;Biological Markers;brain behavior;Brain Injuries;Brain region;Brain scan;care coordination;Caregivers;Characteristics;Clinical;Clinical Management;clinically relevant;cognitive neuroscience;Communication impairment;Complex;Data;Deceleration;Dimensions;disability;Dissociation;Education;Generations;Goals;Growth;Health;Human;Impairment;improved;Individual;insight;Knowledge;Language;language impairment;Left;Lesion;lexical;Linear Models;Linear Regressions;Literature;Location;Longitudinal Studies;Maps;Measures;Mentorship;Methods;Modeling;neural;neural correlate;neuroimaging;Neuronal Plasticity;Non-linear Models;novel;Outcome Measure;outcome prediction;Patients;Pattern;Performance;phonology;post stroke;Practice Management;Production;Prognosis;prognostication;Provider;Psychometrics;Recovery;Rehabilitation therapy;Research;Research Personnel;Sampling;Semantics;Series;Severities;skills;sound;Speech;Stroke;stroke recovery;Techniques;Time;tool;translational research program;vector

PROJECT_TITLE: Neural correlates and recovery of naturalistic language production in aphasia


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_DEPT: SURGERY

PHR: NARRATIVE Multiple modifiable barriers cause race- and location-based disparities in accessing and receiving evidence-based, guideline-concordant care among patients with foregut cancers. This proposal uses a mixed methods approach to identify these barriers from the perspectives of patients, caregivers, and medical stakeholders, as well as from electronic health records. This information will be used to develop a clinic-based screening tool to identify patients at risk for for non- receipt of guideline concordant therapy, thereby enabling the effective allocation of resources and interventions to improve care for patients at greatest risk for disparities in care.

PI_NAMEs: FONSECA, ANNABELLE L (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: access disparities;Address;Advocate;Alabama;Appointment;Area;Biliary;cancer care;cancer health disparity;Cancer Patient;career;Caregivers;Caring;Cessation of life;Clinic;clinical application;Code;Communities;Community Health;Complex;Continuity of Patient Care;Data;Development;Disparity;disparity reduction;Educational workshop;Electronic Health Record;Esophagus;Ethnic Origin;evidence base;evidence based guidelines;Excision;experience;Failure;Focus Groups;Funding;Future;Goals;Guidelines;health care disparity;Health Disparities Research;health disparity;Health Services Accessibility;Health system;Healthcare Systems;Hospital Administrators;implementation science;improved;Incidence;Individual;individual patient;Inequity;Inferior;Institution;instrument;Intervention;Interview;K-Series Research Career Programs;Knowledge;Literature;Liver;Location;longitudinal, prospective study;Malignant Neoplasms;Measurable;Measures;Mediating;Mediation;Medical;Medicine;Mentorship;Methods;Modeling;modifiable risk;multidisciplinary;National Comprehensive Cancer Network;National Institute on Minority Health and Health Disparities;novel;Oncologist;Oncology;Pancreas;Patient Care;patient navigation;patient oriented research;Patients;pilot test;predictive modeling;Primary Care Physician;Primitive foregut structure;Process;Prognosis;prospective;Provider;Proxy;Race;Reduce health disparities;Research;Research Methodology;Research Personnel;Resource Allocation;Risk;Risk Factors;risk prediction;risk prediction model;Rural;rurality;sabbatical;Scientist;screening;Screening procedure;Site;skills;sociodemographic disparity;sociodemographic factors;sociodemographic predictors;sociodemographics;Socioeconomic Status;Statistical Models;Stomach;Structure;successful intervention;Surgeon;survival disparity;System;system-level barriers;Testing;tool;Training;Training Programs;treatment disparity;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: Reducing health disparities in foregut cancers by using modifiable barriers to predict risk for inequitable care: a novel implementation sciencebased approach


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases

PI_NAMEs: GRIMES, CATHERINE LEIMKUHLER (contact)

PROJECT_TERMS: Acetylation;Acetylmuramyl-Alanyl-Isoglutamine;Affinity;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antibodies;Antibody Response;Antibody Therapy;Antigens;Bacteria;Bacterial Infections;bacterial resistance;Carbohydrates;Cell Wall;clinically relevant;combat;Complex;Coupled;Coupling;Crosslinker;Data;Delaware;Development;Dimensions;Disaccharides;Elements;Family;fighting;flexibility;Generations;Glycopeptides;glycosylation;Gram-Negative Bacteria;Grant;Health;Human;Human body;Infection;Innate Immune Response;Libraries;Link;Methicillin;Methicillin Resistance;methicillin resistant Staphylococcus aureus;Microbial Biofilms;Modification;Molecular Target;monomer;Monosaccharides;Morbidity - disease rate;mortality;novel;novel strategies;particle;pathogen;pathogenic bacteria;Penicillins;Peptides;Peptidoglycan;phosphodiester;Polymers;Polysaccharides;Positioning Attribute;Production;programs;Reproducibility;Resistance;resistant strain;Role;Staphylococcus aureus;Structure;success;Teichoic Acids;Testing;Therapeutic;Therapeutic antibodies;Universities;Vancomycin;Vancomycin Resistance;Vertebral column;Viral;Virulence;Virulent;Work;World Health Organization

PROJECT_TITLE: Probing the role of peptidoglycan modification in the antibody response to Staphylococcus aureus


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: PROJECT NARRATIVE Diffuse intrinsic pontine glioma (DIPG) is a deadly pediatric brain tumor for which no curative treatment option currently exists. This proposal will explore developing splice-modulating antisense oligonucleotides (ASOs) to skip the exon that contains the H3.3 K27M mutation found in 70-80% of DIPG patients, leading to disrupted translation of the disease-defining mutant protein with the potential to reduce tumor burden and prolong survival. Knowledge gained from this proposal will advance our understanding of molecular targets in DIPG, potentially offer a new therapeutic option for further clinical drug development, and provide justification for use of antisense oligonucleotides in the treatment of genetic disorders and diseases.

PI_NAMEs: YANG, LUCIA  (contact)

PROJECT_TERMS: Antibodies;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Base Pairing;Binding;Biological Assay;Brain Neoplasms;Brain Stem;Cell Differentiation process;Cells;Central Nervous System;Chemistry;chemotherapy;Child;Childhood Brain Neoplasm;Childhood Glioma;clinical candidate;Clinical Drug Development;Code;Codon Nucleotides;Compensation;Complex;curative treatments;Data;design;Differentiation Antigens;Diffuse intrinsic pontine glioma;Disease;drug development;effective therapy;Electrophoretic Mobility Shift Assay;Excision;Exhibits;exon skipping;Exons;FDA approved;gain of function mutation;Genetic Diseases;Glial Fibrillary Acidic Protein;Glioma;Goals;H3 K27M mutation;Heterozygote;Histone H3;Histone H3.3;Histones;Human;Immunofluorescence Immunologic;in vivo;Initiator Codon;Injections;Kinetics;Knowledge;Lead;Local Therapy;Location;Lysine;Manuscripts;Mediating;Messenger RNA;Methionine;Methods;Methylation;Mitochondria;Modality;Molecular Target;mouse model;mutant;Mutate;Mutation;Nature;Neoplasms;neoplastic cell;neural;Neuroglia;Neuronal Differentiation;Neurons;novel therapeutics;Oncology;Operative Surgical Procedures;overexpression;paralogous gene;Pathologic;Patients;Pediatric Neoplasm;Point Mutation;Polycomb;pre-clinical;prevent;Proliferating;protein expression;protein H(3);Proteins;Protocols documentation;Radiation therapy;Research;restoration;Reverse Transcriptase Polymerase Chain Reaction;RNA;RNA Splicing;RNA-Binding Proteins;Role;side effect;Site;Site-Directed Mutagenesis;Specificity;Survival Rate;Therapeutic;Toxic effect;Translations;tumor;Tumor Burden;tumor diagnosis;tumor growth;Tumor Volume;Tumor-Derived;tumorigenesis;Visualization;Western Blotting;Xenograft procedure

PROJECT_TITLE: Inducing H3F3A exon skipping with antisense oligonucleotides as an approach to treat diffuse intrinsic pontine glioma


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: GALVESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: Narrative: HIV reservoirs are generated in several tissues, including the CNS. However, the nature and mechanism by which these viral reservoirs are generated are unknown. We propose to characterize the myeloid viral reservoirs in the CNS to metabolically eradicate these reservoirs from the CNS.

PI_NAMEs: EUGENIN, ELISEO A (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Address;alpha ketoglutarate;Amino Acids;Animal Model;antiretroviral therapy;Apoptosis;Autopsy;BIM Bcl-2-binding protein;Blood;Brain;Carbon;CD4 Positive T Lymphocytes;Cell Separation;Cell Survival;cell type;Cells;Chronic Disease;curative treatments;Data;DNA Integration;Effectiveness;Energy-Generating Resources;Enzymes;Generations;Genetic;Glucose;Glutamate-Ammonia Ligase;Glutamates;Glutaminase;Glutamine;Goals;HIV;HIV Infections;Human;Impaired cognition;In Vitro;in vivo;Individual;Infection;Inflammation;innovation;Interruption;laser capture microdissection;latent HIV reservoir;Life;Lipids;Location;Macrophage;Malignant Neoplasms;Medicine;Messenger RNA;Metabolic;Metabolic Pathway;metabolic profile;metabolomics;Methamphetamine;Microbiology;Microglia;Myelogenous;Myeloid Cells;Nature;neuroAIDS;Neurotransmitters;novel therapeutics;Persons;Phase II Clinical Trials;Phylogenetic Analysis;Population;prevent;Production;protein expression;Proteins;Proteome;Proteomics;Protocols documentation;Publications;Reporting;Reproducibility;Residual state;Resistance;response;Sampling;Source;System;T-Lymphocyte;therapeutic target;Tissues;translational medicine;Translational Research;Viral;viral rebound;Viral reservoir;Viremia;Virus;Virus Replication

PROJECT_TITLE: Metabolic strategies to eliminate CNS Myeloid Viral Reservoirs


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: HAFLER, DAVID A. (contact)

PROJECT_TERMS: Activities of Daily Living;Adopted;Aftercare;Agonist;anti-PD-1;Autoimmune Diseases;Autoimmunity;Blood;Brain;brain cell;brain tissue;CD4 Positive T Lymphocytes;Cell Culture System;Cell Physiology;Cell Separation;cell type;Cells;Central Nervous System Diseases;checkpoint therapy;Circulation;Clinical Management;clinical translation;Clinical Trials;Clonal Expansion;Controlled Clinical Trials;Coupled;Data;Data Set;Development;Disease;Double-Blind Method;effector T cell;Equilibrium;Exhibits;Experimental Models;Frequencies;Functional disorder;Gene Expression Profile;genetic manipulation;Genetic Transcription;Glioblastoma;Goals;Health;Human;human disease;human model;Immune;Immune Tolerance;immune-related adverse events;Impairment;In Vitro;in vivo;Inflammatory;insight;Interferon Type II;Investigation;Macrophage;Malignant Neoplasms;Mediator;Monoclonal Antibodies;monocyte;mouse model;multiple omics;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;Myeloid Cells;novel therapeutic intervention;Operative Surgical Procedures;Pathogenicity;Pathway interactions;Patients;PD-1 blockade;PD-1/PD-L1;PDL1 pathway;peripheral tolerance;Phase;Phenotype;Placebo Control;Play;prevent;Primary Cell Cultures;Program Research Project Grants;programmed cell death ligand 1;programmed cell death protein 1;receptor;Regulatory T-Lymphocyte;Resectable;Role;Sampling;Sequence Analysis;short hairpin RNA delivery;Signal Induction;Signal Transduction;single cell ATAC-seq;single cell sequencing;single nucleus RNA-sequencing;single-cell RNA sequencing;System;T-Cell Proliferation;T-Lymphocyte;Technology;Therapeutic;Tissues;transcriptome sequencing;transcriptomics;tumor

PROJECT_TITLE: Project 3: Role of Coinhibitory receptors in regulating Immune Tolerance in the Human Brain


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Public Health Relevance In this renewal application we propose the continued development of the Drug Dependence Epidemiology Training (DDET), a program to support pre- and post-doctoral training in substance use and substance use disorders. Our goal is to increase the number and quality of health professionals who apply expertise in epidemiology, biostatistics, prevention science, and services research to substance use research use research. We have a demonstrated commitment to enhancing diversity within the drug research community, as well as special emphasis in training on: HIV and Hepatitis C, epidemiological and statistical methods, social and structural factors, psychiatric disorders, and emerging issues, such as overdose prevention and SARS-CoV-2.

PI_NAMEs: JOHNSON, RENEE M.;MAHER, BRION S (contact)

PROGRAM_OFFICER_NAME: LOPEZ, MARSHA

PROJECT_TERMS: Epidemiology;National Institute of Drug Abuse;Training Programs

PROJECT_TITLE: NIDA Epidemiology Training Program


ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE This research project will study a molecular link between metabolic stress and innate immunity. This research is relevant to public health because it will uncover a new fundamental biological pathway that activates the immune system, impacting our understanding of infectious disease, autoimmunity, and cancer.

PI_NAMEs: BACHOVCHIN, DANIEL  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Affect;Antioxidants;Autoimmune Diseases;Autoimmunity;Binding;Biological;Biological Assay;CASP1 gene;Cell Death;Cell membrane;Cells;Communicable Diseases;Complex;cytokine;Data;disease-causing mutation;Electron Transport;Enzymes;Glutathione;Glutathione Disulfide;glutathione peroxidase;Goals;Homeostasis;Hydrogen Peroxide;Hyperactivity;IL18 gene;Immune system;Inflammasome;Inflammatory;inhibitor;Innate Immune System;Knowledge;Laboratories;Leucine-Rich Repeat;Link;Lytic;Malignant Neoplasms;marenostrin;Mediating;Metabolic stress;Mitochondria;Molecular;Monitor;Multiprotein Complexes;Mutation;N-terminal;Natural Immunity;Nucleotides;Nutrient;Oxidants;Oxidation-Reduction;Oxidative Stress;Oxidoreductase;pathogen;Pathway interactions;Patients;Pattern recognition receptor;Peptide Hydrolases;Play;prevent;Process;Proteins;Proteolysis;Public Health;Reactive Oxygen Species;Reagent;recruit;Reporter;Research;Research Project Grants;restraint;Role;Selenocysteine;Serine Proteinase Inhibitors;Signal Transduction;Site;small molecule inhibitor;Source;Starvation;Stress;Testing;Therapeutic;Time;TXN gene;Work

PROJECT_TITLE: Redox control of the NLRP1 inflammasome

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


PI_NAMEs: FINN, M.G.  (contact)

PROJECT_TERMS: adaptive immune response;Adjuvant;Affinity;Anti-Bacterial Agents;Antibodies;Antibody Affinity;Antigen Presentation;Antigen-Presenting Cells;Antigens;B-Lymphocytes;Bacterial Infections;Bacterial RNA;Capsid Proteins;carbohydrate structure;Carbohydrates;CD209 gene;Cells;cellular targeting;chemical stability;Chemicals;Chemistry;combat;Complement Receptor;Conjugate Vaccines;Dangerousness;density;design;Development;Dimensions;Disease;Drug Delivery Systems;Drug resistance;Engineering;Epitopes;Feedback;fighting;Formulation;Freeze Drying;Friends;Generations;Genetic;Germ Lines;Glycopeptides;Goals;Health;Human;Hydrogels;Immune;Immune response;Immune system;Immunologic Sensitization;Immunologic Stimulation;Immunologics;Implant;improved;insight;Laboratories;Learning;Ligands;lymph nodes;Modification;Molecular;Molecular Profiling;Molecular Target;nanoparticle;nanoparticle delivery;Nature;Nucleoproteins;Oligosaccharides;Outcome;pathogen;pathogenic bacteria;Pattern recognition receptor;Peptides;Peptidoglycan;Polysaccharides;Positioning Attribute;Preparation;Preventive vaccine;Process;Production;programs;Proteins;receptor;reconstitution;recruit;Refrigeration;Reporting;response;Rhamnose;RNA;scaffold;Serotyping;Signal Induction;Signal Transduction;small molecule;Streptococcus pneumoniae;Structure;Structure of germinal center of lymph node;success;sugar;System;T-Lymphocyte;Testing;therapeutic vaccine;Time;tool;Trisaccharides;uptake;vaccine delivery;vaccine development;Vaccines;Virus-like particle;Work

PROJECT_TITLE: Delivery of anti-bacterial glycan vaccines to cells and subcellular compartments


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative: A major contributor to altered gene expression and chromatin reorganization in endocrine-related cancers is nuclear receptor signaling. Hormone therapies are currently the cornerstone of treatment for most patients, however, a deeper understanding of nuclear receptor regulation of epigenetics will help combat tumor recurrence and therapeutic resistance. The proposed work will not only add depth to our current understanding of nuclear receptor biology, but also advance our ability to effectively treat hormone-dependent cancers with therapies that target nuclear receptors.

PI_NAMEs: GILLIS, NOELLE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;Affect;antagonist;ATP phosphohydrolase;Binding;Biological Process;Biology;cancer cell;Cell Line;Cells;Characteristics;ChIP-seq;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;Clinical;Clinical Research;cofactor;combat;Data;Death Rate;Development;effective therapy;Endocrine;Environment;Epigenetic Process;epigenetic regulation;epigenetic silencing;Event;Exhibits;Family;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genetic Transcription;genome-wide analysis;Genomics;Growth;Higher Order Chromatin Structure;Homeostasis;hormonal signals;hormone receptor-positive;hormone response element;hormone therapy;Hormones;Human;Individual;insight;interest;Ligands;Maintenance;Malignant - descriptor;malignant endocrine gland neoplasm;Malignant neoplasm of thyroid;Malignant Neoplasms;Mediating;member;Metabolism;Modeling;Mutation;Normal Cell;novel;novel therapeutics;Nuclear Hormone Receptors;Nuclear Receptors;Pathway interactions;patient prognosis;Patients;Phase;Phenotype;Physiological;Physiology;Play;Postdoctoral Fellow;prognostic indicator;programs;receptor binding;Receptor Cross-Talk;receptor function;Receptor Signaling;recruit;Recurrence;Recurrent tumor;Regulation;Reproduction;Research;Research Project Grants;Resistance;response;restoration;Role;Signal Transduction;SMARCA4 gene;Structure;synergism;targeted treatment;Technical Expertise;Testing;Therapeutic;therapeutic target;therapy resistant;THRB gene;thyroid disruption;Thyroid Gland;Thyroid Hormone Receptor;Thyroid Hormone Receptor Beta;Thyroid Hormones;thyroid neoplasm;Tissues;Training;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;Translating;tumor growth;tumor progression;Tumor stage;Tumor Suppressor Proteins;tumorigenic;Work;Xenograft procedure

PROJECT_TITLE: Nuclear Receptor Regulation of Epigenetics in Endocrine-Related Cancers


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: The goal of the short term research training program is to increase the number of optometrists who will do rigorous basic, clinical and translational research on normal vision and vision disorders. The program provides the initial step toward this goal by providing optometry students with an intensive exposure to research for twelve weeks early in their professional training. We aim to motivate talented optometry students to continue reseach training at the MS or PhD level, to include research in their careers, and to contribute to improvements in vision care.

PI_NAMEs: FRISHMAN, LAURA J. (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Aging;Animals;Anterior;Area;Basic Science;Binocular Vision;bioimaging;Biometry;career;Caring;Cellular biology;Clinical;clinical practice;Clinical Research;Communication;computer program;Electronics;evidence base;experience;Exposure to;Eye diseases;falls;Fellowship;Fostering;Funding;Health;Health Professional;Health Science Library;Immunology;improved;instrumentation;interest;Journals;Learning;meetings;Mentors;Methodology;Modernization;Molecular Biology;ocular surface;oculomotor;Optometry;programs;Public Health;Qualifying;recruit;Refractive Errors;repaired;Reproducibility;Research;Research Design;Research Project Grants;Resources;responsible research conduct;Scholarship;Schools;Science;Scientist;Services;skills;spatiotemporal;Structure;Students;System;Training;Training Programs;Translational Research;Underrepresented Populations;Underrepresented Students;Universities;Vision;vision development;Vision Disorders;Vision research;vision science;Visit;Visual;visual optics;Visual Pathways;Women's Group;Work

PROJECT_TITLE: Short Term Training in Health Professional Schools


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative This is a training grant proposal for interdisciplinary training of predoctoral and postdoctoral fellows in skin biology. The goal is to train future skin biologists who will use multidisciplinary approaches to tackle diseases of the skin, a high priority for NIAMS. The training has implications for skin diseases with barrier dysfunction, wound healing, vascular lesions, and pigment cell diseases such as vitiligo, melasma, nevi and melanoma.

PI_NAMEs: ANDERSEN, BOGI  (contact);GANESAN, ANAND K

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Biology;Skin;Training Programs

PROJECT_TITLE: Interdisciplinary Training Program in Skin Biology


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Alzheimer’s disease (AD) is a global public health crisis that specifically impacts the health of synapses, the nodes at which neurons connect to one another to form networks in the brain. Early traumatic brain injury (TBI) is the best-established environmental risk factor for AD, but the structural and mechanistic connections between TBI and AD are largely unknown. This study seeks to characterize synaptic neurodegeneration resulting from TBI and determine its connection to AD, which may help identify new targets for treating neurodegeneration and for preventing acute brain injuries from progressing to dementia.

PI_NAMEs: KUMMER, TERRANCE T (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acute Brain Injuries;Admixture;advanced disease;Age;aged;Aging;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyloidosis;Animal Model;Area;Atrophic;Automobile Driving;axon injury;behavioral outcome;Biochemical Process;Biological;Brain;Brain Diseases;Brain Injuries;Brain region;Cause of Death;Chemosensitization;Chronic;chronic traumatic encephalopathy;Clinical;clinical translation;clinically relevant;Cognition;Cognitive;Complement;Complement Activation;complement pathway;complement system;Complex;Data;demented;Dementia;Diffuse;disability;Disease;effective therapy;Elements;Emotional;empowerment;Environmental Risk Factor;Epidemiology;Epigenetic Process;Evaluation;Event;Excitatory Synapse;Face;Functional disorder;Genetic;gray matter;Half-Life;Head;Health;Human;Image;Image Analysis;Imaging Device;Impaired cognition;improved;Individual;Injury;Innate Immune System;innovation;Intervention;life span;Link;Measures;Mediating;Mediator;middle age;mild traumatic brain injury;Modeling;Monitor;mouse model;Mus;Nanostructures;Nerve Degeneration;neural;neural circuit;neurobehavioral;neuroinflammation;Neurological disability;neuron loss;Neurons;neuropathology;Neuropil;Neuropsychology;novel;Outcome;Pathologic;Pathology;Pattern;pharmacologic;Phase;Play;pre-clinical;prevent;Process;Public Health;Reproducibility;resilience;Role;Senile Plaques;social;Structure;superresolution imaging;Symptoms;Synapses;tau aggregation;tau Proteins;Tauopathies;Therapeutic;therapeutic target;Time;tool;Trauma;Traumatic Brain Injury;white matter;young adult

PROJECT_TITLE: Connecting Alzheimer's Disease to Traumatic Synaptic Neurodegeneration

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PI_NAMEs: TEYTON, LUC  (contact)

PROJECT_TERMS: Address;Affinity;Antibiotic Resistance;Antibiotics;Antibodies;Antibody titer measurement;Antigenic Variation;Antigens;Automobile Driving;B cell repertoire;B-Lymphocytes;Bacteria;Bacterial Infections;Bacteriology;Binding;Biological Assay;Biological Testing;biophysical analysis;Biophysics;Blood;CD4 Positive T Lymphocytes;Cell Maturation;Cells;Chemicals;Chemistry;Child;Conjugate Vaccines;design;Development;diabetic;Dimensions;Dissent;Elderly;Epitopes;Evaluation;fighting;Formulation;Generations;Germ Lines;Germ-Line Mutation;Glycopeptides;Goals;Haemophilus influenzae;Haptens;Helper-Inducer T-Lymphocyte;Histocompatibility Antigens Class II;Immune;Immune response;Immune system;Immunity;Immunization;immunodeficiency;Immunology;Immunotherapy;improved;in vivo;Influenza B Virus;insight;Intervention;Kidney;Kinetics;Knowledge;Link;man;Measurable;microbial;microbiome;Modality;Modeling;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mus;Neisseria meningitidis;next generation;novel strategies;Passive Immunotherapy;pathogen;Pathogenicity;Patients;Peptidoglycan;Phagocytosis;Polysaccharides;Population;Populations at Risk;Positioning Attribute;Process;Proteins;prototype;Race;Reagent;receptor;Recombinant Antibody;Recombinants;response;Serotyping;Staphylococcus aureus;Streptococcus pneumoniae;structural biology;Structure;Structure of germinal center of lymph node;Surface;System;T cell response;T-Lymphocyte;Teichoic Acids;Transplantation;vaccination outcome;Vaccine Design;vaccine effectiveness;vaccine immunogenicity;Vaccines;Work

PROJECT_TITLE: Molecular basis of glycan recognition by T and B cells


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE Tuberculosis (TB) is the leading infectious disease killer worldwide and a leading cause of death among people with HIV. While it is well established that in areas with rifampin-resistant or multidrug-resistant TB (RR/MDR-TB) HIV increases the number of RR/MDR-TB cases, it remains unclear if HIV impacts the transmission and evolution of RR/MDR-TB. This research project will integrate epidemiologic, clinical and genomic data to characterize HIV- mediated transmission and evolution of RR/MDR-TB in the Western Cape Province, South Africa.

PI_NAMEs: BOUTON, TARA CATHERINE (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: absorption;Address;Affect;African;analysis pipeline;antiretroviral therapy;Area;Automobile Driving;Award;biobank;Biometry;career;Caring;case finding;Cause of Death;Clinical;Clinical Data;clinical epidemiology;co-infection;cohort;Collection;Communicable Diseases;Communities;Compensation;Competence;Containment;cost;cost effective;Country;Data;deep sequencing;Development;Disease;drug quality;Drug resistance;Drug resistance in tuberculosis;Drug resistant Mycobacteria Tuberculosis;Environment;Epidemic;epidemiologic data;Evolution;experience;Extramural Activities;fitness;Funding;Genetic Epistasis;genomic data;genomic epidemiology;Genomics;Genus Mycobacterium;Goals;Grant;Growth;high risk;HIV;HIV resistance;HIV/TB;improved;In Vitro;Incidence;Individual;Infection;International;Intervention;isoniazid;Isoniazid resistance;K-Series Research Career Programs;Knowledge;Laboratories;Low Prevalence;Mediating;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Minority;Modeling;Molecular Epidemiology;Monitor;multidisciplinary;Multidrug-Resistant Tuberculosis;Mutation;mycobacterial;next generation sequencing;Outcome;Patients;Persons;Pharmaceutical Preparations;Physicians;Population;Positioning Attribute;Predisposition;Preparation;pressure;Prevalence;prospective;Province;Public Health;Publishing;recruit;Regimen;Research;Research Personnel;Research Project Grants;Resistance;resistance mutation;resistant strain;Resources;Retrospective cohort;Rifampicin resistance;Risk;Risk Factors;Robin bird;Role;Sampling;Scientist;Site;skills;South Africa;South African;Specimen;Sputum;Techniques;Therapeutic;Time;Training;Translating;transmission process;Tuberculosis;Tuberculosis diagnosis;tuberculosis treatment;United States National Institutes of Health;Variant;whole genome;Work

PROJECT_TITLE: Understanding HIV's impact on RR/MDR-TB development and transmission through genomics

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Dysregulation of histone methylation has emerged as a major cause of neurodevelopmental disorders including intellectual disabilities and autism spectrum disorders. While histone methylation plays important roles in any cell types, the proposed study is designed to identify methyl-histone regulations that are unique to neuronal cells. The obtained knowledge may be used to form the basis upon which abnormal methyl-histone regulations can be selectively targeted in the brain without affecting other organs.

PI_NAMEs: IWASE, SHIGEKI  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Address;Adopted;Affect;Affinity;Alternative Splicing;AT-Hook Motifs;autism spectrum disorder;Binding;Biochemistry;Brain;Cancer cell line;Catalytic Domain;cell type;Cells;Cellular biology;Chromatin;chromatin modification;Chromatin Remodeling Factor;Chromatin Structure;Complement;Complex;Cryoelectron Microscopy;Data;Defect;demethylation;design;Development;Disease;DNA;DNA Binding;DNA Sequence;embryonic stem cell;Enzymes;Excitatory Synapse;Exons;experimental study;functional genomics;Gene Expression;Genomic approach;Goals;Higher Order Chromatin Structure;histone demethylase;Histone H3;histone methylation;histone modification;Histones;Human;Human Genetics;Impairment;In Vitro;in vivo;insight;Intellectual functioning disability;interdisciplinary approach;Investigation;KDM1A gene;Knock-out;Knowledge;Lead;Lysine;Mediating;Mediator;Missense Mutation;Modeling;mouse model;Mus;Mutate;neurodevelopment;Neurodevelopmental Disorder;Neurons;novel strategies;Nucleosomes;Nucleotides;Organ;Pathogenesis;Pathologic;Patients;Pattern Recognition;PHD Finger;Play;Protein Isoforms;protein protein interaction;Publishing;Reaction;Reader;reconstitution;recruit;Regulation;Reporting;Research;RNA Splicing;Role;Specificity;structural biology;Substrate Specificity;synaptogenesis;Testing;therapeutic target;transcription factor;transcriptome

PROJECT_TITLE: A Neuron-specific Methyl-histone Regulatory Complex

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


PHR: Project Narrative Understanding how membrane proteins fold is central to understanding membrane protein misfolding diseases. We propose studies of the assembly and stability of single-span membrane proteins in living Escherichia coli. This allows us to gain insights into membrane protein stability in the context of the cellular milieu.

PI_NAMEs: WHITE, STEPHEN H. (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: ATP phosphohydrolase;Binding;Biological;Biological Models;Cells;Chimeric Proteins;Cryoelectron Microscopy;Cystic Fibrosis;Cytoplasm;Cytoplasmic Tail;Disease;Drug Targeting;Electrons;Engineering;Escherichia coli;experimental study;Foundations;Goals;Growth;human disease;Hydrophobicity;in vivo;in vivo Model;insight;Lipids;Membrane;Membrane Proteins;Methods;molecular dynamics;Motor;nanodisk;Paper;Pathway interactions;Peptide Hydrolases;periplasm;Process;Protein Family;protein folding;protein misfolding;Proteins;secretion process;Signal Recognition Particle;Structure;System;Temperature;Work

PROJECT_TITLE: Membrane Protein Folding and Assembly

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


NIH_SPENDING_CATS: Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: NORFOLK

ORG_DEPT: PEDIATRICS

ORG_NAME: EASTERN VIRGINIA MEDICAL SCHOOL

ORG_STATE: VA

PHR: Project Narrative Smoke-free public housing policies have been mandated by the U.S. Department of Housing and Urban Development (HUD). However, our work suggests these policies are considered to be so unfair by residents that compliance is severely undermined, with potentially negative unintended consequences. Our goal is to verify how these policies can be harmful and propose adaptations to increase their effectiveness.

PI_NAMEs: ENGLAND, KELLI ;SHEEHAN, BRYNN  (contact)

PROGRAM_OFFICER_NAME: LAND, STEPHANIE R

PROJECT_TERMS: Affect;Air;Area;Attitude;authority;Biological Markers;Communities;community advisory board;community based participatory approach;community based participatory research;Disease;Effectiveness;Environment;environmental tobacco smoke;environmental tobacco smoke exposure;Exhalation;Exhibits;experience;fine particles;Focus Groups;Fright;Goals;Group Interviews;Health;health disparity populations;Housing;implementation framework;implementation strategy;improved;Individual;Institution;Intervention;Interview;Justice;Laws;Left;Legitimacy;Low income;Measures;Mediating;member;Methods;metropolitan;Modeling;Monitor;Nicotine;Outcome;Perception;Persons;Policies;prevent;Process;Property;Proxy;Public Housing;Punishment;Recommendation;Reporting;response;Rights;Risk;Sampling;Smoke;Smoke-free home;Smoker;Smoking;soda tax;Surveys;Testing;theories;Tobacco;Trust;U.S. Department of Housing and Urban Development;Walking;willingness;Work

PROJECT_TITLE: Using Differences in Perceived Legitimacy and Resident Compliance to Promote Fair and Effective Implementation of Smoke Free Housing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DIRH-N(09)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: ARLINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

PHR: Narrative Mycobacterium tuberculosis infections require long and onerous treatment: antibiotic regimens that could clear infections more quickly would improve patient outcomes. This proposal seeks to determine how Mtb battens down the hatches of its cell wall during stress, thus increasing antibiotic tolerance. This work will characterize some of the molecular mechanisms responsible for treatment recalcitrance in Mtb, and will lay the foundation for future screens for anti-tolerance drugs.

PI_NAMEs: BOUTTE, CARA CHENEY (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Affect;antibiotic tolerance;Antibiotics;Binding;biological adaptation to stress;Cell model;Cell Polarity;Cell Wall;Data;Dependence;design;drug candidate;Drug Controls;Drug Screening;Drug Targeting;Drug Tolerance;effective therapy;Effectiveness;Enzyme Precursors;Enzymes;Event;Foundations;Future;genetic regulatory protein;Genus Mycobacterium;Goals;Growth;hatching;improved;In Vitro;Infection;Left;Measures;men;Metabolic;Metabolism;Modeling;Molecular;molecular modeling;mycobacterial;Mycobacterium smegmatis;Mycobacterium tuberculosis;novel therapeutics;Outcome;Patient-Focused Outcomes;Peptidoglycan;Permeability;Pharmaceutical Preparations;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Process;Protein Dephosphorylation;Protein Isoforms;Proteins;Recycling;Regimen;Regulation;Research;Role;Signal Pathway;Signal Transduction;Signaling Protein;Site;Stress;Testing;treatment strategy;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Work

PROJECT_TITLE: Control of cell wall synthesis and antibiotic tolerance in mycobacteria

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE: Attacking complex diseases such as cancer, arthritis, and Alzheimer’s dementia will require a new generation of researchers who are both outstanding physicians and skilled scientists who understand how to harness new technologies to advance human health. This application requests support for the Medical Scientist Training Program at the University of California, San Francisco, which is achieving this goal by offering a rigorous, integrated, and supportive program that results in graduates who hold both M.D. and Ph.D. degrees.

PI_NAMEs: KAO, AIMEE  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Grant;Medical;National Research Service Awards;Scientist;Training;Training Programs

PROJECT_TITLE: Medical Scientist Training Program (T32 NRSA Training Grant)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Exposures to deprivation (e.g., hunger) and threat (violence) during mid-to-late adolescence impact the mental and physical health of youth; however, we need more information on how potentially modifiable factors affect the impact of such exposures. The CAMINANDO-MH study examines the impact of exposures to threat and food deprivation on the mental health of 400 Latin American teens who migrated to the US as unaccompanied adolescents. We will follow them over 18 months to assess how psychological, cognitive, and social factors (e.g., daily stressors, supports) affect their mental health trajectories to clarify how to improve their outcomes.

PI_NAMEs: LEWIS-FERNANDEZ, ROBERTO ;ORJUELA, MANUELA A (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Accounting;Acute;Adolescence;Adolescent;Adolescent Development;Adult;Adverse event;Affect;Age;Buffers;Chronic;Cognitive;cognitive capacity;cognitive function;Communities;community organizations;community setting;Conflict (Psychology);coping;Coping Skills;Data;depressive symptoms;deprivation;Development;Dislocations;early adolescence;Economics;Effectiveness;Equation;European;Event;executive function;Exhibits;experience;Exposure to;follow-up;Food deprivation (experimental);Fostering;Future;generalized anxiety;Health;Health Status;Hunger;improved;improved outcome;Infrastructure;innovation;Intervention;Latin America;Latin American;Latino;Life;Lived experience;Longitudinal Studies;Mental Depression;Mental Health;Methods;Migrant;migration;Minor;Modeling;New York City;novel;novel strategies;Outcome;Parents;Pattern;Phase;physical conditioning;Pilot Projects;post-traumatic stress;Post-Traumatic Stress Disorders;Process;psychologic;Psychological Factors;psychosocial;recruit;Refugees;Reporting;resilience;Resources;Risk;Risk Factors;social;social factors;Social Network;Stress;Stressful Event;stressor;Substance Use Disorder;Symptoms;Teenagers;Testing;Textiles;Violence;Vulnerable Populations;Well in self;Work;Youth

PROJECT_TITLE: Mental Health of Latino Adolescent Who Migrate without a Parent: Understanding Risk and Identifying Resilience and Coping Strategies

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

PHR: Narrative IPUMS Health Surveys provides free, streamlined access to detailed, population-representative, individual-level data used by researchers to uncover sources of health disparities, to understand the mismatch between America's large health investments and poor health outcomes, and to examine the role of insurance coverage and access to needed care in improving population health and reducing health disparities. Continuing support for IPUMS Health Surveys will extend past and current health data infrastructure investments, allowing researchers to employ these rich yet complex data in scientifically rigorous and replicable studies of population health, health financing, and health policy.

PI_NAMEs: BLEWETT, LYNN A (contact);DREW, JULIA AR

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Adult;Affect;Affordable Care Act;application programming interface;Awareness;black men;career;Caring;Child;Child Mental Health;Communities;Complex;complex data;cost;Data;data access;Data Analyses;Data Collection;data infrastructure;data structure;Databases;Demography;Depressed mood;design;Documentation;Drops;Drug Prescriptions;Education;Educational workshop;Event;Exhibits;Family;Frequencies;Funding;Health;health care service;health care service utilization;health data;health disparity;Health Expenditures;Health financing;Health Insurance;Health Policy;Health Services Accessibility;Health Status;Health Surveys;Health system;Healthcare;Household;Improve Access;improved;Individual;Insurance Coverage;Investments;Medical;Medical Care Costs;Metadata;Mission;mortality;National Health Interview Survey;National Institute of Child Health and Human Development;novel strategies;opioid epidemic;outreach;Persons;Policies;poor health outcome;Population;Population Dynamics;population health;Population Study;Procedures;Public Housing;Readability;Reduce health disparities;Reproductive Health;Research;Research Personnel;Research Support;Research Training;Resources;Role;Services;social health determinants;Source;Subgroup;Surveys;symposium;Syphilis;System;Time;tool;Training;trend;Visual;web site;webinar;Work

PROJECT_TITLE: U.S. Health Surveys Microdata for Population Health Research

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: PROJECT NARATIVE Antibiotic resistance is an increasing problem especially in gram-negative bacteria where the permeability barrier created by the outer membrane (OM) excludes many antibiotics; yet, although a barrier, the pathways responsible for synthesizing and transporting OM components are potential targets for the development of antimicrobials that can weaken the OM. Our proposed study will investigate the biogenesis of a conserved component of the cell envelope of Enterobacterales, enterobacterial common antigen (ECA), which has functions in maintenance of the OM permeability barrier. The knowledge of ECA biogenesis gained through our work will facilitate functional studies of ECA and identify potential targets for antimicrobial small molecules.

PI_NAMEs: MITCHELL, ANGELA MARIE (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acute;Address;Anabolism;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;Antigens;antimicrobial;aqueous;bile salts;Biochemical;Biochemical Reaction;Biogenesis;Biology;Carbohydrates;cell envelope;Cell Membrane Permeability;Cells;Cellular Structures;Cessation of life;Cyclization;Defect;Development;economic cost;Enteral;enterobacterial common antigen;Environment;Escherichia;Escherichia coli;Escherichia coli K12;Exclusion;experience;Feedback;Genes;Genetic;genetic analysis;Genetic Determinism;Genetic Screening;genetic selection;Genetic Transcription;Genomics;Goals;Gram-Negative Bacteria;Head;Hydrophobicity;improved;Infection;innovation;insight;interest;Investigation;Klebsiella;Knowledge;Length;Link;Lipids;Maintenance;member;Membrane;Mutation;Nature;novel;Nutrient;Pathogenicity;Pathway interactions;Peptidoglycan;Periodicity;periplasm;Permeability;Phenotype;Phospholipids;Physiological;Play;posttranscriptional;Production;Reaction;Regulation;Regulatory Pathway;response;Role;Salmonella;small molecule;Stress;Surface;Techniques;Transcription Regulation Pathway;United States;Work;Yersinia

PROJECT_TITLE: Biogenesis of cyclic and phospholipid-linked enterobacterial common antigen


NIH_SPENDING_CATS: Genetics

ORG_CITY: Boulder

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative Paternal mitochondrial elimination and radiation-induced bystander effects are two vitally important, distinct, and dynamic biological processes essential for stress response, normal cell functions and organismal development. Defects in these two processes can cause multiple human diseases, such as inherited human mitochondrial diseases. This proposal seeks to understand the mechanisms that regulate and execute these two fundamental biological events and identify new genes and pathways important for these two processes, leading to identification of new therapeutic targets or ideas to treat human diseases caused by abnormalities in paternal mitochondrial elimination and improve disease treatment by reducing side effects caused by radiotherapy and other therapeutic treatments.

PI_NAMEs: XUE, DING  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Animals;Biochemical;Biological;biological adaptation to stress;Biological Process;Bystander Effect;Cell Physiology;Cells;Defect;Development;Disease;Ensure;Event;fitness;Genes;Human;human disease;Impairment;improved;Inherited;Mediating;Mitochondria;Mitochondrial Diseases;Molecular Genetics;new therapeutic target;Normal Cell;novel;Pathologic;Pathway interactions;Process;Proteomics;Radiation;Radiation therapy;response;reverse genetics;side effect;Signal Pathway;Stress;Therapeutic;Work;zygote

PROJECT_TITLE: Fundamental mechanisms of paternal mitochondrial eliminationand radiation-induced bystander effects

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Proper regulation of cell division during the process of making a sperm or egg (termed meiosis) ensures that these crucial cells inherit the correct genetic material. Errors in this process lead to genetic abnormalities, pregnancy loss, and developmental defects. The overall goal of this proposal is to understand the regulation of meiotic cell division, with a focus on mechanisms underlying preferential inheritance of certain chromosomes over others.

PI_NAMEs: LAMPSON, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Biological;Biological Models;Cell division;Cells;Centromere;Chemicals;Chromosome Segregation;Chromosomes;Conflict (Psychology);cost;Defect;Development;DNA;DNA Sequence;egg;Ensure;Evolution;Female;fitness;Genetic;Genetic Materials;Genome;Goals;Hybrids;Inherited;Lead;Link;Meiosis;Microtubules;Modeling;Molecular;Molecular Abnormality;Molecular Evolution;mouse model;Mus;optogenetics;Pathway interactions;Post-Translational Protein Processing;Pregnancy loss;Process;Proteins;recruit;Recurrence;Regulation;Reproductive Biology;reproductive fitness;Satellite DNA;segregation;sperm cell;System;Testing;theories;transmission process;Tubulin;Variant;Work;zygote

PROJECT_TITLE: Cell Biological mechanisms of centromere drive

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ORG_CITY: DETROIT

ORG_DEPT: CHEMISTRY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project Summary Research on human health has fundamentally changed in the last 20 years. Modern genomics and proteomics technologies have carefully characterized health-related events, which has opened the door to asking more complex questions about normal and disease states. Correspondingly, to confront complex research challenges, the career opportunities to Ph.D. scientists have diversified, including multiple non-academic positions (e.g., industry, biotechnology, government, publishing). Along with this research progress and changing career landscape, the biomedical culture has placed greater emphasis on quantitative data analysis, rigor and reproducibility, and transparency to ensure quality and accuracy of research findings and safety to minimize risk to scientists and the environment. To take advantage of this unprecedented opportunity to thoroughly dissect biological systems with high standards of rigor and many career perspectives, a biomedical work force capable of multi-disciplinary, team-driven, and problem-focused thinking is needed. In total, this modern world of biomedical research requires a rethinking of the Ph.D. training experience. To address the changing needs in biomedical work force training, we have created a Chemistry Biology Interface (CBI) training program at Wayne State University (WSU). WSU has the ideal campus environment for a scientifically rigorous and culturally rich training experience. CBI faculty among six departments and three colleges offer a wealth and diversity of research expertise for graduate training. WSU has in place a series of professional development activities to augment career preparation. The diverse undergraduate population at WSU also synergizes and supports an equally diverse graduate community. Building upon these strengths, the CBI program will augment the graduate training within core disciplines by promoting multi-disciplinary research knowledge and collaboration facilitated by cross-campus mentoring and peer-to-peer advising. These outcomes will be achieved through a series of CBI activities that center around an individualized “My Ph.D.” theme. The foundational activity is an annual "My Ph.D." workshop focused on career skills surveying, assessment, and planning, which will be led by CBI student peers and faculty for multi-level mentoring. Complementing the individualized skills evaluation, multi-disciplinary research, scientific rigor, communication skills, and peer cohort building/networking will be accomplished through annual CBI symposia, biweekly seminar activities, a team- taught and literature-based CBI course, a co-mentoring Ph.D. committee structure, early and sustained academic advising, internal and external research experiences (ATTRACT), and community outreach events (ACT OUT). Through these meaningful activities, WSU Ph.D. graduates will form a strong scientific identity with discipline-specific skills and informed multi-disciplinary perspectives. The combination of research breadth, skills depth, and enhanced mentoring facilitates the confident, solution-oriented, and collaborative thinking needed to address complex biological questions and migrate through a diverse career backdrop.

PI_NAMEs: CHOW, CHRISTINE S;PFLUM, MARY KAY H (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Chemistry Biology Interface Training Program at Wayne State University

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]