NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Social Determinants of Health

PI_NAMEs: APPLEYARD, CAROLINE B (contact)

PROJECT_TERMS: Address;American Society of Clinical Oncology;anti-cancer research;Basic Cancer Research;Biometry;Bone Marrow Transplantation;Cancer Center;cancer clinical trial;cancer health disparity;cancer therapy;career;Career Choice;career development;Career Mobility;Caring;Clinical;Clinical Oncology;clinical practice;clinical training;Clinical Trials;Communities;cultural competence;design;Development;Diagnosis;Doctor of Philosophy;doctoral student;Education;education research;Educational workshop;Effectiveness;Evaluation;experience;Exposure to;Faculty;faculty mentor;Feedback;Fellowship Program;Florida;Goals;graduate school;Grant;Health Disparities Research;health disparity;Health Sciences;Hematology;Hispanic;Immersion;improved;Industry;interest;Interest Group;investigator training;Island;Latino;Latino Population;Malignant Neoplasms;Medical;Medical Students;Mentors;Mentorship;minority health;Needs Assessment;Oncologist;Oncology;Operative Surgical Procedures;Outcome;Participant;patient engagement;peer coaching;Population;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Prevention;programs;Puerto Rican;Puerto Rico;recruit;Research;Research Personnel;Residencies;Rotation;Scholarship;Science, Technology, Engineering and Mathematics;Scientist;senior faculty;Series;Site;STEM research;Students;success;summer research;Surgical Oncology;Training;tumor;undergraduate student;Universities;Urology;Vision;Writing

PROJECT_TITLE: Research Education Core


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PONCE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: PONCE SCHOOL OF MEDICINE

ORG_STATE: PR

PI_NAMEs: JIMENEZ CHAVEZ, JULIO CESAR (contact)

PROJECT_TERMS: Address;Awareness;Behavior;bilingualism;biobank;Biologic Characteristic;Cancer Burden;Cancer Center;cancer education;cancer health disparity;Cancer health equity;cancer prevention;cancer risk;Characteristics;Communication;Communities;community advisory board;community collaboration;community engagement;Community Health Education;community organizations;Community Outreach;Community Participation;community partners;community research;Cuban;Early Diagnosis;Education and Outreach;Educational Activities;Educational Curriculum;Equity;ethnic minority population;Ethnic Population;Event;evidence base;Evidence based program;Feedback;Florida;Genetic Counseling;Genetic Risk;Goals;Health;Health Disparities Research;Health Sciences;high risk;Hispanic;improved;Individual;interest;intervention refinement;Knowledge;Latino;Latino Population;Malignant Neoplasms;member;Mexican;outreach;Participant;Patient Recruitments;Persons;Pilot Projects;Population;preference;Prevention;programs;promoter;Puerto Rican;Puerto Rico;racial minority population;recruit;Reporting;Research;Research Activity;research data dissemination;Research Personnel;Research Priority;Research Project Grants;Research Support;screening;Screening for cancer;Skin Cancer;social culture;Source;success;telephone based;tool;Training;training opportunity;Translational Research;Underserved Population;United States;Universities;virtual;Woman;Work

PROJECT_TITLE: Outreach Core


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Substance use has been declared as a public health emergency, fueled by alarmingly high relapse rate (as high as 90%). This mechanistic human study will examine whether down-regulation of enhanced preferential attention to drug-related cues to reduce craving and prolong abstinence in individuals with cocaine use disorder. Successful completion of this project will advance mechanistic research into developing attention regulation as a potential behavioral intervention for relapse prevention in substance use disorders.

PI_NAMEs: PARVAZ, MUHAMMAD ADEEL (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: Abstinence;Accounting;addiction;Affect;Affective;Aftercare;Alcohols;Arousal;Attention;attentional bias;Attenuated;Back;Behavior Therapy;Behavioral;Cessation of life;Chronic;Clinic;Clinical;clinical effect;clinical outcome assessment;Clinical Research;clinically significant;Cocaine;cocaine cue;cocaine overdose;cocaine relapse prevention;cocaine use;Cocaine use disorder;Cocaine Users;Cognitive;cognitive process;cognitive reappraisal;comparison control;Control Groups;COVID-19 pandemic;craving;Cross-Sectional Studies;cue reactivity;Cues;Data;Down-Regulation;Drug Addiction;drug seeking behavior;Drug usage;Electroencephalography;emotion regulation;Enrollment;Evidence based intervention;Exposure to;follow-up;Foundations;gaze;human study;improved;Incubated;Individual;innovation;Intervention;Longitudinal Studies;Measures;Mediating;Minority;Neurocognitive;novel;Outcome;Outcome Measure;outcome prediction;Participant;Patient Self-Report;Pharmaceutical Preparations;Population;predict clinical outcome;Prediction of Response to Therapy;Procedures;Process;prolonged abstinence;public health emergency;Randomized;randomized, controlled study;reduced substance use;Regulation;Relapse;relapse prediction;relapse prevention;Reporting;Research;Research Personnel;Smoker;substance use;Substance Use Disorder;Surveys;Techniques;Testing;Time;Training;treatment research;treatment response;United States;visual tracking

PROJECT_TITLE: Cognitive Reappraisal for Mitigating Incubation of Cocaine Cue-Reactivity

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: SEATTLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE For many human diseases, we do not know which cell types and which genes within those cell types are at the root of the problem. Rapid advances in DNA sequencing technology now allow us to look inside individual cells from healthy tissue, but we lack algorithms and software for comparing such measurements to those from diseased tissue. This proposal aims to develop generally applicable software tools that will allow scientists to compare the regulation of genes in healthy and diseased tissue, as well as uncover fundamental mechanisms in embryonic development and other biological processes.

PI_NAMEs: KIMELMAN, DAVID ;TRAPNELL, BRUCE COLSTON (contact)

PROGRAM_OFFICER_NAME: GAO, JEAN XUEJING

PROJECT_TERMS: Algorithms;animal data;Animals;ATAC-seq;Atlases;Biological Assay;Biological Process;Bulla;Catalogs;cell type;Cells;Chemicals;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Computer software;Data;Data Set;defined contribution;Development;Developmental Biology;Disease;Disease Progression;DNA;DNA Methylation;DNA sequencing;Elements;Embryo;Embryonic Development;Engineering;Epigenetic Process;epigenome;Evolution;experimental study;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic analysis;Genetic Transcription;genome editing;Goals;histone modification;human disease;Individual;Informatics;insight;interest;knockout gene;Literature;Maps;Measurement;Measures;Mediating;Methods;Molecular;Output;Pathogenesis;Pathologic;Pathology;Phenotype;Physiological;Population;programs;Publishing;Regression Analysis;Resolution;Sampling;Scientist;single cell analysis;single cell genomics;single cell sequencing;single-cell RNA sequencing;software development;Software Tools;Specimen;Systems Development;Techniques;Technology;Time;Tissues;tool;tool development;Transcriptional Regulation;transcriptome sequencing;Untranslated RNA;vertebrate genome;Work;Zebrafish

PROJECT_TITLE: New software tools for differential analysis of single-cell genomics perturbation experiments

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Pediatric;Physical Activity;Prevention

ORG_CITY: IRVINE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: MoTrPAC Narrative While there are many important health benefits of physical activity, how exercise exerts its effects is not fully understood. A more comprehensive understanding of the molecular mechanisms underlying the responses to exercise would significantly impact public health. Continuation of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) will achieve its objective of generating a comprehensive map of the molecular responses to acute exercise and exercise training with a long-range goal of elucidating the mechanisms by which exercise improves health.

PI_NAMEs: COOPER, DAN M;RADOM-AIZIK, SHLOMIT  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: 17 year old;18 year old;Acceleration;Acute;Adolescent;Adult;Age;age group;Age Years;Ancillary Study;Animals;Award;Bioinformatics;Biological Process;Blood;Charge;Chemicals;Child;Childhood;Chronic;Clinical;clinical center;Clinical Protocols;Clinical Research;Clinical Trials Data Monitoring Committees;cohort;Collaborations;Collection;Communication;Communities;COVID-19 pandemic;Data;design;Development;Disease;Disease Outcome;Educational Intervention;endurance exercise;Enrollment;Ensure;ethnic minority;Exercise;Exercise Test;exercise training;falls;follow-up;Frequencies;Funding;Gender;gender equality;Goals;Health;Health Benefit;Heterogeneity;Human;improved;Individual;innovation;insight;Institution;Institutional Review Boards;Intervention;life span;Manuals;Manuscripts;Maps;Measurement;Minority Groups;Molecular;Multi-site clinical study;multiple omics;novel;Observational Study;operation;pandemic disease;Participant;Pathway interactions;Phase;Phenotype;phenotypic data;Physical activity;Physiological;pre-clinical;Procedures;Protocols documentation;Puberty;public database;Public Health;quality assurance;Race;racial minority;Randomized;Randomized, Controlled Trials;recruit;Recruitment Activity;Research;Research Personnel;Resistance;resistance exercise;Resources;response;Schedule;sedentary;sex;Site;Suspensions;Time;Tissues;Training;Training Programs;Transducers;United States National Institutes of Health;Visit;working group;Youth

PROJECT_TITLE: Molecular Transducers of Physical Activity Consortium (MoTrPAC): Pediatric Clinical Center


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: ANN ARBOR

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The major goal of this grant application is to determine the molecular mechanisms by which the transcriptional co-activators YAP/TAZ control age-related skin dermal extracellular matrix (ECM) homeostasis. In this application, we will test the novel hypothesis that dermal ECM homeostasis is governed by the adaptation of fibroblasts to the state of the surrounding ECM microenvironment and that this “outside-in adaptation” is critically regulated by YAP/TAZ.

PI_NAMEs: FISHER, GARY J (contact);QUAN, TAIHAO

PROGRAM_OFFICER_NAME: KATIYAR, PRAGATI

PROJECT_TERMS: Acceleration;Affect;age related;aged;Aging;Applications Grants;Architecture;Atrophic;Behavior;Cells;Chronology;Clinical;Collagen;Collagen Fibril;conditional knockout;Contusions;Cytoskeleton;Data;Dermal;Deterioration;Disease;Extracellular Matrix;Extracellular Matrix Degradation;Fibroblasts;functional decline;Gene Modified;Goals;Growth;Homeostasis;Human;humanized mouse;Immunity;Impairment;Individual;Interstitial Collagenase;Investigation;late life;Life;Link;Malignant Neoplasms;mechanical force;mechanical properties;Mechanics;mechanotransduction;Mediating;Modeling;Molecular;Morbidity - disease rate;Morphology;mouse model;Neonatal;novel;Pathogenesis;Pathway interactions;Phenotype;Physiological;postnatal;Production;Proteins;Regulation;resilience;response;restoration;Risk Factors;Signal Pathway;Skin;Skin Aging;Skin Cancer;skin disorder;Stretching;Testing;Thinness;Transcription Coactivator;wound healing

PROJECT_TITLE: YAP/TAZ Regulation of Extracellular Matrix Homeostasis

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: HERE! Project Narrative School-based health centers have a growing evidence-base in addressing disparities children in rural communities face across health, behavioral health, and educational outcomes. With many rural children and families being hard hit by economic downturns and the national pediatric mental health crisis, support around social determinants of health needs is a priority. The current cluster randomized crossover trial across 12 rural school-based health centers will assess the impact of rural school-based community health workers on student attendance, socieo-emotional learning and school climate, and school-based health center onsite and telehealth services utilization versus an enhanced usual care condition.

PI_NAMEs: NELSON, EVE-LYNN  (contact)

PROGRAM_OFFICER_NAME: BLACHMAN, DARA

PROJECT_TERMS: Address;Adoption;Adult;Automobile Driving;Behavior Disorders;behavioral health;behavioral outcome;care delivery;Child;Child Mental Health;Child Support;Childhood;Chronic;Chronic Disease;Clinic;Clinical Trials;cohort;Communities;community advisory board;Community Health;Community Health Aides;Community Networks;community organizations;community partnership;Cross-Over Trials;design;developmental disease;Discrimination;Disparity;Dose;Economics;Education;educational atmosphere;Emergency Situation;Emotional;emotional abuse;Evaluation;evidence base;experience;Face;Family;Food;Foundations;Goals;Health;health disparity;health equity;health service use;Health Services;Healthcare;healthcare community;high risk;Housing;Hunger;improved;Individual;intergenerational;Intervention;Kansas;kindergarten;Lead;Learning;Maintenance;Measures;Medical;medical specialties;meetings;Mental Health;Neighborhood Health Center;Outcome;Performance;Persons;physical abuse;poor health outcome;Population;Poverty;prevent;Prevention;Preventive service;primary outcome;Process;public health emergency;racism;Randomized;Resources;response;Risk;Rural;rural area;Rural Community;rural disparities;school based health center;Schools;secondary outcome;Services;Site;social emotional learning;social health determinants;Social outcome;social stigma;Social Work;State Government;Student Health Services;Students;Suicide attempt;System;systematic review;telehealth;Testing;Time;Transportation;Trauma;treatment as usual;Trust;twelfth grade;universal prevention;Youth

PROJECT_TITLE: Health Equity and Rural Education (HERE!) Clinical Trial: A Healthcare-Community Partnership Leveraging School-Based Community Health Workers to Improve Student Attendance


NIH_SPENDING_CATS: Cancer;Hematology;Lymphatic Research;Lymphoma;Precision Medicine;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE I am committed to the successful implementation of NCI-funded clinical trials and have devoted a large portion of my career to ensuring such studies are available to patients nationwide. I will utilize the support provided by this award to improve accrual to studies throughout the state of Georgia and access to leadership roles for trainees and junior colleagues. I will leverage leadership in real world evidence cohorts to develop the next generation of impactful trials.

PI_NAMEs: COHEN, JONATHON B. (contact)

PROGRAM_OFFICER_NAME: TAWAB-AMIRI, ABDUL

PROJECT_TERMS: Address;American College of Radiology Imaging Network;Award;Cancer Center;career;Clinic;Clinical;Clinical Trials;cohort;Collaborations;Communication;Communities;community engagement;Community Outreach;Conduct Clinical Trials;Country;Data;Development;Disease;Early Therapeutic-Clinical Trials Network;Eastern Cooperative Oncology Group;Enrollment;Ensure;experience;Funding;Future;Growth;Home;Improve Access;improved;improved outcome;innovation;Institution;interest;Lead;Leadership;Lymphoma;Malignant Neoplasms;metropolitan;Modality;Monitor;National Clinical Trials Network;next generation;Oncologist;participant enrollment;Patient-Focused Outcomes;Patients;Persons;Positioning Attribute;programs;Research;Research Personnel;Resources;Role;Safety;Series;Site;skills;Specialist;standard of care;success;Therapeutic Studies;Tumor Expansion;Universities;virtual;working group

PROJECT_TITLE: Increasing Participation in NCI-Funded Clinical Trials at Winship Cancer Institute


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Machine Learning and Artificial Intelligence;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BERKELEY

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Discovering biological features underlying disease mechanisms is crucial to develop effective treatments and therapies, but follow-up studies verifying relationships between features and disease traits are costly. We propose a recommendation system based on the PCS framework that aims at efficient discoveries for high yields in experimentation. We will leverage this system to recommend genes and interactions for follow-up gene-silencing experiments to advance the mechanistic understanding of cardiac hypertrophy.

PI_NAMEs: YU, BIN  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Algorithms;Awareness;Biological;Case Study;clinical practice;Clinical Trials;cohort;Complex;cost;Data;Data Science;Decision Trees;Dependence;Disease;disease heterogeneity;disease phenotype;effective therapy;Effectiveness;Entropy;Etiology;experimental study;flexibility;follow-up;Follow-Up Studies;gene interaction;Gene Silencing;Genes;Genetic;Genome;genome wide association study;Hand;Head;Heart Diseases;Heart Hypertrophy;Heritability;human induced pluripotent stem cells;improved;induced pluripotent stem cell derived cardiomyocytes;insight;Investigation;Learning;Linkage Disequilibrium;Measures;Methodology;Methods;Modeling;multimodality;National Institute of General Medical Sciences;Noise;novel;Population;Problem Sets;Process;Proteins;random forest;Recommendation;Research Personnel;Risk Factors;Sampling;Signal Transduction;simulation;Small Interfering RNA;Source;Statistical Data Interpretation;Structure;success;Survival Analysis;System;Testing;trait;Validation;Variant;Weight;Work

PROJECT_TITLE: DMS/NIGMS 2: A Stability Driven Recommendation System for Efficient Disease Mechanistic Discovery


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Project Narrative: (3 sentences) Bayesian models that monitor serum vancomycin levels to optimize the delivery of intravenous vancomycin have limitations in achieving a patient-specific pharmacokinetic model. To overcome these limitations, we will develop deep-learning based models suited for time-sequencing data to disentangle complex relationships in big patient data from electronic health records. The success of our models will lead to optimized vancomycin usage, increased patient safety, and reduced healthcare costs through high prediction accuracy and reliability.

PI_NAMEs: NIGO, MASAYUKI  (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: Adverse event;anti-microbial drug;antimicrobial;Architecture;Arizona;Bayesian Modeling;Boston;Clinical;Complex;Creatinine;Critical Illness;Data;data harmonization;Data Set;Data Sources;Databases;deep learning;deep learning model;demographics;Differential Equation;dosage;Dose;Drug Kinetics;Drug toxicity;electronic health data;Electronic Health Record;flexibility;Future;Goals;Guidelines;Health Care Costs;Health Sciences;Healthcare Systems;Hemodialysis;Hospitals;Human;improved;Inpatients;Intensive Care Units;Intravenous;Laboratories;machine learning model;methicillin resistant Staphylococcus aureus;Methodist Church;Mission;model generalizability;Modeling;Monitor;Neural Network Simulation;Output;patient population;patient safety;patient subsets;Patients;Pediatric Intensive Care Units;Peripheral;Pharmaceutical Preparations;pharmacokinetic model;population based;Population Heterogeneity;predictive modeling;pregnant;prototype;Publishing;Recommendation;recurrent neural network;Renal Replacement Therapy;Research;Sampling;Serum;Source;Structure;Subgroup;success;System;Techniques;Testing;Texas;Therapeutic;Time;Toxic effect;trend;United States;United States National Institutes of Health;Universities;Update;Validation;Vancomycin

PROJECT_TITLE: Deep Learning Based Pharmacokinetic Model for Vancomycin

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Neurosciences;Pain Research;Palliative Care;Patient Safety;Primary Health Care;Racial and Ethnic Minority Health Research;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The proposed Achieving Equity through SocioCulturally-informed, Digitally-Enabled Cancer Pain managemeNT (ASCENT) clinical trial will test whether a novel digitally enabled, collaborative approach to team based pain management can improve clinical outcomes and reduce longstanding and devastating disparities among rural dwelling and Hispanic/Latinx cancer survivors.

PI_NAMEs: AUSTIN, JESSICA DANIELLE;CHEVILLE, ANDREA LYNNE (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: Address;Adoption;Adult;Advanced Malignant Neoplasm;Affect;Algorithms;arm;cancer care;cancer health disparity;cancer pain;Cancer Pain Management;Cancer Patient;Cancer Survivor;cancer therapy;care coordination;care delivery;care outcomes;care providers;care seeking;Caring;Case Manager;Cessation of life;Characteristics;Chronic Cancer Pain;chronic pain;Clinical;clinical decision support;Clinical Trials;collaborative approach;collaborative care;Communities;community organizations;Data;Data Collection;demographics;design;Detection;Development;digital;Dimensions;disability;Disease;Disparity;disparity reduction;Effectiveness;effectiveness clinical trial;effectiveness evaluation;Elderly;Electronic Health Record;Elements;Engineering;Equity;ethnic minority;evidence base;experience;flexibility;functional improvement;geographic barrier;Goals;Guidelines;health care service utilization;Health Services Accessibility;Health system;Healthcare Systems;Hispanic;Hybrids;implementation evaluation;implementation strategy;improved;individualized medicine;Institutionalization;intense pain;Intervention;Language;Latinx;Learning;Linguistics;Link;Location;Low income;Machine Learning;Malignant Neoplasms;Mediating;Mediator;Medical;meetings;Modality;Modeling;Monitor;Moods;multidisciplinary;multilevel analysis;multimodality;novel;opioid epidemic;Outcome;Outcome Measure;Pain;Pain management;pain outcome;pain reduction;patient navigation;patient navigator;patient oriented;Patient Outcomes Assessments;patient population;patient portal;Patient Recruitments;Patients;Pattern;Persistent pain;personalized care;Persons;Pharmaceutical Preparations;Phase;Physical Function;preference;prescription opioid;Procedures;Provider;provider communication;Quality of life;Randomized;randomized, clinical trials;Rehabilitation therapy;Reporting;Research;Resource-limited setting;Resources;response;role model;Rural;rural area;rural dwellers;rural Hispanic;rural residence;Services;Sleep;social;social culture;social health determinants;Specialist;Survivors;Symptoms;System;team-based care;telecare;Testing;treatment as usual;treatment planning;Unemployment;virtual;Vulnerable Populations;Work

PROJECT_TITLE: Achieving Equity through SocioCulturally-informed, Digitally-Enabled Cancer Pain managemeNT” (ASCENT) Clinical Trial


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Despite its life-saving potential, lung cancer screening uptake remains extremely low in the United States. The goal of this proposal is to identify and pilot test the feasibility of multilevel strategies to facilitate uptake of lung cancer screening. This research will help address an urgent public health need to help all eligible patients benefit from a proven strategy for the early detection of lung cancer.

PI_NAMEs: RICHMOND, JENNIFER ANN (contact)

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: Academic Medical Centers;Address;Administrator;Advisory Committees;Age;American;Annual Reports;Area;Award;Awareness;Black race;Cancer Control;Cancer Etiology;cancer prevention;Cancer Survivor;career;Collaborations;Communities;community advisory board;community engaged research;community engagement;Congresses;Decision Making;design;Effectiveness;effectiveness evaluation;Eligibility Determination;Environment;Equity;Ethnic Origin;evidence base;Exclusion;experience;feasibility testing;Future;Goals;health equity;Health Personnel;Health system;Healthcare;implementation framework;implementation science;implementation strategy;improved;Individual;Inequity;innovation;Intervention;Interview;Investigation;Knowledge;Leadership;Life;low dose computed tomography;Low income;Lung;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Medical;Mentors;Methods;mortality;Nurses;Participant;patient-level barriers;Patients;Phase;pilot test;Population;Population Heterogeneity;post implementation;Preventive service;Process;Provider;provider communication;Public Health;Race;racial diversity;racism;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reporting;Research;Resources;routine screening;Scientist;screening;Screening for cancer;screening program;Smoke;smoking cessation;Smoking History;sociodemographics;socioeconomic diversity;socioeconomics;Structure;System;Training;Trust;trustworthiness;United States;United States Preventative Services Task Force;uptake

PROJECT_TITLE: Developing a Trustworthy Multilevel Intervention to Improve Lung Cancer Screening


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Physical Injury - Accidents and Adverse Effects;Rural Health;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE People living in rural areas are more likely to have a serious injury and more like to die from that injury than their urban counterparts. This disparity can be reduced by appropriate use of air medical helicopters to quickly transport injured patients to a trauma center from rural regions, but use of this resource when others may need it, risk of crashing, and high cost make it important to use air medical transport (AMT) by helicopter appropriately. Decisions by first responders about which patients benefit from AMT are frequently inaccurate, and this research will help us identify who needs to be transported by helicopter and ultimately reduce disparities for rural patients that rely on air medical helicopters for life-saving care after injury.

PI_NAMEs: BROWN, JOSHUA B (contact)

PROGRAM_OFFICER_NAME: JOSEPH, SUSAN KALAPURA

PROJECT_TERMS: Air;Algorithms;Ambulances;Blood Transfusion;care delivery;Caring;Consensus;cost;Data;data registry;Decision Making;Disparity;disparity reduction;Emergency medical service;Emergency Medicine;Emergency response;evidence base;experience;Face;Feedback;Fees;Financial Hardship;first responder;Future;Geography;Goals;Guidelines;Healthcare Systems;Helicopter;high risk;Hospitals;Hour;improved;improved outcome;injured;Injury;innovation;Intervention;Life;Literature;Measures;Medical;Medical emergency;meetings;Methodology;Methods;Minor;mortality risk;multidisciplinary;novel;Online Systems;Outcome;Outcome Assessment;patient oriented;patient safety;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Persons;Physiology;Pre-hospitalization care;preservation;prospective;recruit;Registries;Research;Resources;Risk;Rural;rural America;rural Americans;rural area;rural patients;Rural Population;Safety;severe injury;Standardization;Surveys;System;Time;tool;Trauma;trauma care;trauma centers;Trauma patient;Triage;underserved rural area;Validation;Variant;Work

PROJECT_TITLE: Establishing a consensus-based definition of air medical transport need for rural patients after injury

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Infectious Diseases;Kidney Disease;Microbiome;Urologic Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE  FimH and FmlH are critical adhesion proteins that enable uropathogenic E. coli (UPEC) to cause serious and often drug-resistant urinary tract infections (UTIs). Current attempts to treat UTIs must overcome unique challenges due to the complexity of UPEC pathogenesis and drug delivery limitations. The proposed research will identify long-lived D-peptides that block these adhesion proteins and serve as a potential alternative treatment for challenging UTIs.

PI_NAMEs: ROBINS, MARCY  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Acetylgalactosamine;Acute;Adhesions;Affinity;alternative treatment;Amino Acids;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Avidity;Bacteria;Bacterial Adhesins;bacterial community;Bacteriophages;Binding;Biological Assay;Bladder;Bypass;Catheterization;Cell-Matrix Junction;Cells;chemical synthesis;Chemicals;Chronic;Circular Dichroism;Circular Dichroism Spectroscopy;Collaborations;commensal bacteria;Complex;Consensus Sequence;cost;Cytoplasm;cytotoxicity;deep sequencing;design;Disease Progression;Drug Delivery Systems;Drug Kinetics;Drug resistance;efficacy evaluation;efficacy study;enantiomer;Filtration;fitness;Fluorescence Polarization;Galactose;glycomimetics;Goals;Growth;gut microbiome;gut microbiota;Half-Life;Hemagglutination;Image;immune clearance;Immune response;immunogenicity;improved;in vitro Assay;in vivo;Infection;Inflammation;inhibitor;Injections;Kidney;kidney cell;Knowledge;Laws;Lead;Lectin;Libraries;Ligation;Lower urinary tract;Mammalian Cell;Mannose;Measures;Mediating;Methods;Microbial Biofilms;Modeling;Molecular Conformation;Monitor;mouse model;Mus;next generation sequencing;novel;Output;Pathogenesis;peptide chemical synthesis;Peptide Hydrolases;peptide L;Peptide Phage Display Library;Peptide Synthesis;Peptides;Periodicity;Phage Display;Phase;Pilum;Population;prevent;Proteins;Randomized;Recombinant Proteins;Recombinants;Recurrence;recurrent infection;Reporting;Research;resistant strain;Risk;Risk Reduction;screening;Secondary Protein Structure;Solid;Specificity;Structure;Surface;Transitional Epithelium;Treatment Efficacy;Urinary tract;Urinary tract infection;Urination;Urine;Uropathogenic E. coli;vaginal microbiota;Validation;Virulence;Woman;X-Ray Crystallography

PROJECT_TITLE: D-peptide Inhibitors of Uropathogenic E. coli Adhesion Proteins to Treat Urinary Tract Infections


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Physical Activity;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE There is a maternal health crisis in the United States. Although severe maternal morbidity (SMM) is largely preventable, Black birthing people are disproportionately affected by SMM and associated risk factors. The purpose of this study is to test the effectiveness of an integrated care model approach at two different levels of intensity designed to facilitate timely, appropriate care for high-risk Black birthing people and reduce risk for SMM.

PI_NAMEs: FITZPATRICK, STEPHANIE LENAY (contact)

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: Address;Affect;arm;Behavior;behavioral health;Birth;Black race;care outcomes;Caring;chatbot;Clinical;Clinical Services;comorbidity Index;Data;Data Collection;design;Diagnosis;disability;Discipline of obstetrics;disparities in morbidity;Disparity;disparity reduction;Effectiveness;effectiveness testing;Electronic Health Record;Emotional;Enrollment;Ensure;experience;First Pregnancy Trimester;fitbit;Fostering;Goals;Health;health care disparity;Health Personnel;high risk;Home Blood Pressure Monitoring;hospital readmission;Hospitalization;improved;Incidence;Inequity;integrated care;Intervention;longitudinal design;Managed Care;Maternal Health;Maternal Mortality;Measures;Modeling;Monitor;New York;Not Hispanic or Latino;Nurses;Outcome;Participant;Pattern;Persons;Physical activity;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnancy Outcome;prenatal;prevent;programs;Questionnaires;Randomized;Recording of previous events;recruit;Registered nurse;Research Personnel;Risk;Risk Factors;Risk Reduction;Self Management;Services;severe maternal morbidity;social;Social support;Social Work;Surveys;Technology;Telephone;Testing;Time;Touch sensation;two-arm study;United States;women's outcomes

PROJECT_TITLE: Maternal OutcoMes (MOMs) Program: Testing Integrated Maternal Care Model Approaches to Reduce Disparities in Severe Maternal Morbidity


NIH_SPENDING_CATS: Cachexia;Cancer;Clinical Research;Digestive Diseases;Nutrition;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The majority of patients with pancreatic cancer suffer from involuntary weight loss, fatigue, and frailty, known as cachexia. These effects of cancer limit patients' quality of life, their ability to tolerate treatment, and can contribute to mortality. Our studies investigate how pancreatic cancer changes metabolism of fat stores to cause cachexia in the hopes of developing new effective treatments.

PI_NAMEs: GROSSBERG, AARON  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Ablation;Adipose tissue;Area;Back;Body Weight decreased;Cachexia;Cancer Cachexia;cancer complication;Catabolism;Clinical Trials;Collaborations;cytokine;Data;Development;Dietary Intervention;Disease;Eating;effective therapy;energy balance;Energy-Generating Resources;Fasting;Fatigue;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;frailty;Genetic;genetic approach;Glucose;Goals;Hepatic;Heterogeneity;Homeostasis;Human;Impairment;In Vitro;in vivo;Infection;Inflammation;Inflammatory;insight;Interleukin-6;Intervention;Isotope Labeling;Ketones;Life;life span;Link;lipid metabolism;Lipid Mobilization;Lipids;Lipolysis;Liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Metabolic;Metabolism;metabolomics;Molecular Target;Monitor;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;muscle form;Muscular Atrophy;novel;Nutrient;nutrition;Nutritional;Organ;Organism;Outcome;oxidation;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;pharmacologic;Physical Function;Physiological;Physiology;Plasma;pre-clinical;Pre-Clinical Model;preservation;prevent;Prevention;Process;profiles in patients;prospective;Quality of life;Research;resilience;Role;Sampling;Signal Transduction;Site;Skeletal Muscle;skeletal muscle wasting;stable isotope;Starvation;Supplementation;Testing;Therapeutic;therapeutic target;therapeutically effective;Tissue Banks;tissue resource;tool;tumor;Tumor-Derived;Wasting Syndrome

PROJECT_TITLE: Metabolic vulnerability due to dysregulated lipid metabolism in PDAC cachexia

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative MRI is an exquisitely flexible and sensitive technique, with observable signal changes due to an array of underlying neurobiological and neurodegenerative factors that occur due to cerebrovascular disease, Alzheimer's disease, and traumatic brain injury. However, multiple underlying phenomena (e.g. myelin loss, neuron death, and vascular tissue damage) can cause similar signal changes, thus reducing the specificity with which MR is able to characterize the neurobiology (e.g. of vascular lesions seen in the broad spectrum of neurodegenerative diseases such as Alzheimer’s Disease and post-traumatic neurodegeneration). In this project, we will build and share acquisition and analysis tools that bridge the divide between in vivo MRI images, ex vivo tissue images, and neuropathological diagnosis allowing the development of new innovative technologies for highly specific in vivo pathology mapping with significant clinical impact.

PI_NAMEs: FISCHL, BRUCE ;HUANG, SUSIE YI;VAN DER KOUWE, ANDRE JAN WILLEM (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: 3-Dimensional;Address;Aging;Air;Algorithm Design;Algorithmic Software;Algorithms;Alzheimer's Disease;analysis pipeline;Anatomy;Architecture;Atlases;Automobile Driving;Autopsy;axon injury;Back;Back Injuries;Biological Markers;biomarker discovery;Blood - brain barrier anatomy;Blood Vessels;Brain;Brain Injuries;Brain Mapping;Brain Stem;Cerebellum;Cerebral hemisphere;Cerebrovascular Disorders;Clinical;Cognitive;Collaborations;connectome;Darkness;Data;data streams;Deposition;Detection;Development;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Documentation;Dropout;Environment;ex vivo imaging;flexibility;Functional disorder;Goals;Health;Hemorrhage;high resolution imaging;Histology;Histopathology;Human;Image;Image Analysis;image guided;imaging biomarker;Imaging technology;improved;in vivo;in vivo imaging;Infarction;innovative technologies;Internships;Iron;Label;Lesion;Link;Liquid substance;Location;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Manuals;Maps;medial temporal lobe;Memory;Microscope;Microvascular Dysfunction;millimeter;Morphologic artifacts;multimodality;Myelin;Nerve Degeneration;Neurobiology;Neurodegenerative Disorders;neuron loss;neuropathology;Neurosciences;non-invasive imaging;Pathologic;Pathology;Positioning Attribute;Process;Property;Protocols documentation;Protons;reconstruction;recruit;Research;Research Personnel;Resolution;Sampling;Scanning;Shapes;Signal Transduction;Site;Slice;Specificity;Stains;Stream;structural imaging;System;Techniques;Temperature;Tissue imaging;Tissues;tool;Translations;Traumatic Brain Injury;Traumatic brain injury related dementia;ultra high resolution;Underrepresented Minority;Underrepresented Populations;Validation;validation studies;Variant;vascular cognitive impairment and dementia;white matter;White Matter Hyperintensity;white matter injury

PROJECT_TITLE: An Acquisition and Analysis Pipeline for Integrating MRI and Neuropathology in TBI-related Dementia and VCID


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT According to the CDC database, 6.5 million (10.7%) of Americans aged 65 and older are living with Alzheimer’s disease in 2022, while there are no potent medicines to prevent its onset or progression. In this project, we will test a novel pathogenesis hypothesis and two treatments that target the aggregation of hyperphosphorylated tau. Positive outcomes of this project will shed insights to the mechanisms of Alzheimer’s dementia and may suggest new treatments of this devastating disorder.

PI_NAMEs: KUAN, CHIA-YI  (contact);KUO, MIN-HAO

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: 3xTg-AD mouse;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;American;Apolipoprotein E;apolipoprotein E-4;Apomorphine;Attenuated;Axon;Axonal Transport;Behavioral;Biochemical;biophysical properties;Brain;cingulate cortex;Clinical Treatment;Cognitive;Cognitive deficits;Cryoelectron Microscopy;Databases;Detergents;Disease;Dose;Estrogen Receptor Modulators;Exhibits;Exposure to;Female;Heparin;Hippocampus;Histologic;human old age (65+);hyperphosphorylated tau;Impaired cognition;Impairment;In Situ Nick-End Labeling;In Vitro;in vivo;Induced Neurons;inhibitor;Injections;insight;J20 mouse;Kinesin;Knock-in Mouse;Lysosomes;male;Medicine;Microtubule-Associated Proteins;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Movement;Mus;Mutant Strains Mice;Neurites;Neurofibrillary Tangles;neuron loss;Neurons;neuropathology;neurotoxic;neurotoxicity;novel;Osteoporosis prevention;Outcome;Pathogenesis;Pathologic;Peptides;Phosphorylation Site;Physical condensation;Pilot Projects;Postmenopause;prevent;protective effect;Proteins;public health relevance;Raloxifene;Recombinants;Reporter;Reporting;Respiration;sarkosyl;Structure;Superoxides;Symptoms;System;tau aggregation;tau interaction;tau Proteins;tau-1;Testing;Therapeutic;Toxic effect;Toxicity Tests;Wild Type Mouse;Woman

PROJECT_TITLE: Treating neurotoxicity and cognitive deficits due to hyperphosphorylated tau.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Q(55)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: San Diego

ORG_NAME: CORTECHS LABS, INC.

PHR: Project Narrative When screening for prostate cancer it is often unclear who should be biopsied and if there is a targetable lesion to biopsy, which are critical to the accurate diagnosis of clinically significant prostate cancer. In this proposal, we will develop a set of quantitative and non-invasive tools to help clinicians determine who should be biopsied and where to target the biopsy. These tools will utilize restricted spectrum imaging (RSI), a novel tissue microstructure imaging method, and deep learning to predict the Gleason score of prostate lesions, and incorporate clinical data including age, family history, and genetics to accurately predict current and future risk for clinically significant prostate cancer. 2

PI_NAMEs: WHITE, NATHAN SCOTT (contact)

PROGRAM_OFFICER_NAME: ZHAO, MING

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;accurate diagnostics;Affect;Age;artificial intelligence algorithm;artificial intelligence model;Biopsy;Blinded;cancer therapy;Classification;Clinical;Clinical Data;clinical predictors;clinical risk;Clinical Treatment;clinically significant;cloud platform;Commercial grade;commercial launch;commercialization;Communities;Computer software;convolutional neural network;Data;Data Set;deep learning;deep learning model;demographics;Detection;Diagnosis;Diagnostic;diagnostic tool;Diffusion Magnetic Resonance Imaging;Early Diagnosis;Family;Future;Genetic;Gland;Gleason Grade for Prostate Cancer;Goals;Health Care Costs;Image;imaging modality;Imaging Techniques;improved;Indolent;innovation;Institution;Label;Legal patent;Lesion;Location;Magnetic Resonance Imaging;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Device;men;Methods;Modeling;neural network;neural network architecture;noninvasive diagnosis;novel;Output;overtreatment;Pathologic;Pathology;Performance;Phase;Production;prospective;Prostate;prostate biopsy;prostate cancer risk;prostate lesions;PSA screening;Quality of life;Radical Prostatectomy;radiologist;Radiology Specialty;Reader;Recording of previous events;Restriction Spectrum Imaging;Risk Assessment;Risk Factors;risk prediction model;safety net;Scanning;Screening for Prostate Cancer;Sensitivity and Specificity;software development;Structure;System;Techniques;Testing;Tissues;tool;Training;tumor;United States;Update;usability;Validation;virtual biopsy;wasting;water diffusion

PROJECT_TITLE: RSI-AI: Predicting clinically significant prostate cancer to guide biopsy decisions by combining advanced tissue microstructure imaging with deep learning


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Precision Medicine;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: MADISON

ORG_NAME: AIQ SOLUTIONS, INC.

ORG_STATE: WI

PHR: Project Narrative  Theranostics combines molecular targeted diagnostic and therapeutic radionuclides for imaging and therapy. AIQ Solutions will build a dedicated AI-powered theranostics software -TRAQinform Theranostics- to provide objective and actionable information predicting and summarizing theranostic patient response to meet the currently unmet need for theranostic patient management, not addressed by any existing commercial products.

PI_NAMEs: CORN, PAUL G.;PERK, TIMOTHY  (contact);TAGAWA, SCOTT T

PROGRAM_OFFICER_NAME: TRIPURANI, SWAMY KRISHNA

PROJECT_TERMS: Algorithms;androgen independent prostate cancer;Area;Clinical;clinical decision-making;Clinical effectiveness;Clinical Research;Clinical Trials;clinically relevant;commercialization;Computer software;cost;Data;Decision Making;Dedications;design;Detection;Development;Diagnostic;Discipline of Nuclear Medicine;Disseminated Malignant Neoplasm;Dose;dosimetry;Early identification;Effectiveness;Evaluation;FDA approved;FOLH1 gene;Health Care Costs;Image;Image Analysis;imaging modality;improved;Individual;Legal patent;Lesion;Life;Lutetium;Malignant neoplasm of prostate;Malignant Neoplasms;Manuals;Marketing;Measures;Medical;Medical Oncologist;Modality;Modeling;molecular imaging;Molecular Target;novel;Organ;Outcome;Output;Patient imaging;Patient Recruitments;patient response;Patient Selection;Patient-Focused Outcomes;Patients;Peptide Receptor;Performance;personalized medicine;PET/CT scan;Phase;Physicians;Positioning Attribute;Prediction of Response to Therapy;Probability;Process;prognostic model;prospective;prostate lesions;Prostatic Neoplasms;Quality of life;Radiation Dose Unit;Radiation Oncologist;Radionuclide Imaging;Radionuclide therapy;radiotracer;Reader;receptor;receptor expression;Research;Research Personnel;response;rho;ROC Curve;Small Business Innovation Research Grant;Software Tools;spatiotemporal;standard of care;System;Testing;theranostics;Time;tool;Toxic effect;Tracer;Treatment Efficacy;treatment response;Treatment-related toxicity;tumor;uptake;usability;Validation

PROJECT_TITLE: Comprehensive Assessment of Cancer Theranostics Response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-Z(10)B]


ORG_CITY: MIAMI

ORG_NAME: STEMSYNERGY THERAPEUTICS, INC.

ORG_STATE: FL

PHR: PROJECT NARRATIVE This proposal seeks to continue the pre-clinical development of novel MYC degraders to treat c-myc-dependent non-small cell line cancers (NSCLCs) and colorectal cancers (CRCs). We show that our MYC degraders harbor excellent drug-like properties and are effective in inhibiting the growth of c-myc-dependent NSCLC and CRC in pre-clinical models. Our MYC degraders have potential to impact the lives of millions of cancer patients in U.S. and represent a significant market opportunity.

PI_NAMEs: FEI, DENNIS LIANG (contact);KNOWE, MATTHEW

PROGRAM_OFFICER_NAME: ZANE, LINDA KARINE

PROJECT_TERMS: Adult;Animals;anti-cancer;aurora kinase A;Binding;Biological Assay;Biological Availability;c-myc Genes;cancer cell;Cancer Patient;cancer type;canine model;Canis familiaris;Cell Culture Techniques;Cell Cycle Progression;Cell Death;Cell Line;Cell Physiology;Cell Proliferation;Cellular Assay;Clinical;Clinical Trials;colon cancer cell line;Colorectal Cancer;Dependence;Dissociation;Dominant-Negative Mutation;Dose;Dose Limiting;drug candidate;Drug Kinetics;efficacy evaluation;efficacy testing;functional group;Genes;Genetic Transcription;Grant;Growth;Guidelines;Homeostasis;Human;improved;In Vitro;inhibitor;Intellectual Property;Lead;Legal patent;Liver Microsomes;Malignant neoplasm of lung;Malignant Neoplasms;Marketing;Metabolic;Modeling;Molecular;Molecular Conformation;Monitor;mouse model;multicatalytic endopeptidase complex;Mus;MYC Family Protein;Neuroblastoma;novel;Oral;overexpression;paralogous gene;Patients;Peptides;Permeability;Pharmaceutical Preparations;Phase;Phosphotransferases;Play;Pre-Clinical Model;preclinical development;preclinical safety;Proliferating;Property;Protein-Serine-Threonine Kinases;Proteins;Proto-Oncogene Proteins c-myc;Protocols documentation;Rattus;Research;Resistance;Role;Safety;safety study;Small Business Innovation Research Grant;small molecule;Solubility;Testing;Therapeutic;Therapeutic Agents;Tissues;tool;Toxic effect;Toxicokinetics;Toxicology;transcription factor;Transgenic Mice;Translations;tumor growth;tumor xenograft;tumorigenesis;Validation;Vendor;Xenograft Model

PROJECT_TITLE: Small Molecule MYC Degraders as Novel Cancer Therapeutic Agents

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-T(10)B]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

ORG_CITY: PROVIDENCE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE There are an estimated 11.2 million Mexicans living in the United States, making them by far the largest national origin immigrant group and 25% of all immigrants. The newest sources of large migration from Latin America are the Central American countries of El Salvador, Guatemala and Honduras: from 1990 to 2015 the number of people from these three countries resident in the United States grew from 975,000 to 3.0 million. The Mesoamerican Migration Project will collect survey data in Mexico, El Salvador, Guatemala, Honduras and the U.S. and build on the long-standing NICHD-funded Mexican Migration Project and Latin American Migration Project to provide the most comprehensive dataset for describing, tracking, and explaining current and past migration from Mexico and Central America to the U.S.

PI_NAMEs: LINDSTROM, DAVID P. (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: authority;Authorization documentation;Border Crossings;Central America;Central American;Characteristics;Child;Climate;Communities;cost;Country;Crime;Data;Data Files;Data Set;Databases;design;Development;Documentation;Droughts;Economic Conditions;Educational workshop;El Salvador;Event;experience;Faculty;Family;food insecurity;Funding;gang;Goals;Guatemala;Hand;Homicide;Honduras;Household;Household Heads;Immigrant;Immigration;informant;Infrastructure;innovation;interest;Interview;Interviewer;Journals;Latin America;Latin American;Livestock;Longitudinal trends;male;men;Mesoamerican;Mexican;Mexican Americans;Mexico;Migrant;migration;Monitor;Movement;Municipalities;National Institute of Child Health and Human Development;National origin;Paper;Personal Satisfaction;Persons;Policies;Population;Prevalence;Professional Meetings and Conferences;Questionnaires;recruit;Reporting;Request for Proposals;Research;Research Design;Research Personnel;Sampling;Series;social;social media;Source;Spouses;stem;Surveys;Telephone;Telephone Interviews;Testing;theories;Training;Twitter;United States;Universities;university student;Urbanization;Variant;Violence;Weather;web site;Woman;Writing

PROJECT_TITLE: Public Use Data on Mexican and Central American Immigration

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Breastfeeding, Lactation and Breast Milk;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;HIV/AIDS;Infectious Diseases;Maternal Health;Neurosciences;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health;Women's Health Research

PHR: Project Narrative The success of programs to prevent vertical transmission of HIV has led to a growing population of HIV- exposed, uninfected (HEU) children who, despite not being infected, exhibit neurodevelopmental delays and reduced growth. In this project we will continue to follow a prospectively recruited well-characterized cohort of children without and with HIV exposure, stratified by ART exposure duration, through early childhood with multimodal MR neuroimaging and cognitive assessments around ages 6 and 8 years, examining how factors around birth impact later brain health and how the postnatal environment, including maternal health, influences neurodevelopment and school-readiness. Additionally, we will build capacity for using low-cost mobile MRI scanners to differentiate healthy and atypical neurodevelopment in low-resource settings.

PI_NAMEs: LAUGHTON, BARBARA ;MEINTJES, ERNESTA MARIA;VAN DER KOUWE, ANDRE JAN WILLEM (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: 2 year old;Africa South of the Sahara;Age;Algorithms;antenatal;Behavior assessment;Birth;Brain;brain health;Brain imaging;Cessation of life;Child;Childhood;Clinic;Clinical assessments;Cognition;cognitive performance;cognitive testing;cohort;Collaborations;Communities;comparative;computing resources;Conceptions;cost;Data;Development;Diffusion Magnetic Resonance Imaging;Drug Combinations;early childhood;efavirenz;emtricitabine;Enrollment;Ensure;Environment;Environmental Risk Factor;Exhibits;Exposure to;eye hand coordination;Face;Faculty;fetal;Fetal Development;follow-up;Functional disorder;General Hospitals;Gestational Age;graduate student;gray matter;Growth;Health;High Prevalence;high risk;HIV;HIV Infections;HIV Seropositivity;HIV-1;Home;Human;Human Milk;Image;Imaging technology;Impaired cognition;in utero;inclusion criteria;infancy;Infant;Infant Development;infant nutrition;Infection;Infrastructure;Intervention;Investments;Life;Link;longitudinal analysis;Magnetic Resonance;Magnetic Resonance Imaging;Massachusetts;Maternal Health;maternal wellbeing;Mediating;mental development;Metabolic;Metabolism;microbial;microbiome;Milk;Monitor;Morbidity - disease rate;morphometry;mortality;Mothers;multimodal neuroimaging;multimodality;neonate;neural;neural correlate;neurodevelopment;neuroimaging;Nutritional;Oligosaccharides;Outcome;peer;Performance;perinatal HIV;Personal Satisfaction;Population;Postdoctoral Fellow;postnatal;Pregnancy;Pregnant Women;prenatal;prevent;Prevention Guidelines;programs;prospective;Public Health;Readiness;recruit;Regimen;Reporting;Research Personnel;Resource-limited setting;Risk;Role;Sampling Studies;Schools;Site;social;socioeconomics;South Africa;Spectrum Analysis;success;System;Tenofovir;Testing;three-arm study;tool;Toxic effect;Training;United States National Institutes of Health;Universities;Vertical Transmission;white matter;Woman

PROJECT_TITLE: Neural correlates of in utero HIV and ART exposure: early childhood follow-up of a prospectively recruited cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CN-T(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: PROJECT NARRATIVE Blood flow to the brain is very important for healthy neurological function, but it is dysregulated in patients who suffer strokes, Alzheimer’s disease and other related dementias. Here, we will examine whether strokes can initiate disease processes in astrocytes, a key brain cell that controls brain blood vessels, to cause long-lasting decrease in blood flow and contribute to dementia. Findings from this study may guide the development of novel treatment strategies to prevent or reduce dementia by restoring brain blood flow.

PI_NAMEs: MISHRA, ANUSHA  (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: abeta accumulation;abeta deposition;Abeta synthesis;Ablation;Acute;AD transgenic mice;Adult;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-Protein;Amyloidosis;Architecture;arteriole;Astrocytes;astrogliosis;Attenuated;Autopsy;Behavior;Behavioral;beta amyloid pathology;Bilateral;Biological Assay;Biological Markers;Blood capillaries;Blood flow;Brain;brain cell;brain control;catalyst;cerebrovascular;Cerebrovascular Circulation;cerebrovascular reactivity;Cerebrovascular system;Chronic;Cognitive;cognitive performance;comorbidity;constriction;Coupled;Data;Dementia;design;Development;Discipline;Disease;Early Intervention;emerging adult;Epidemiology;Etiology;Evaluation;experimental study;Exposure to;Functional disorder;Future;Genetic;Health;Human;human old age (65+);Hydroxyeicosatetraenoic Acids;hypoperfusion;Hypoxia;Immunohistochemistry;Impaired cognition;Impairment;improved;in vivo;Infarction;insight;Intervention;Ischemia;ischemic injury;Ischemic Stroke;Lesion;life span;Link;Measurement;Metabolic;metabotropic glutamate receptor 5;Mixed Function Oxygenases;Modeling;Molecular;Monitor;mouse model;Mus;Nerve Degeneration;Nervous System Disorder;Nervous System Physiology;neural;Neuronal Dysfunction;neurovascular;neurovascular coupling;novel;Outcome;Pathogenesis;Pathology;patient population;Patients;Peptide Initiation Factors;pharmacologic;Physiological;Pilot Projects;Play;preservation;prevent;Procedures;Process;receptor;Regulation;Reporting;response;Rodent;Role;Signal Transduction;Slice;Stroke;subcortical ischemic vascular disease;Testing;Tg2576;Therapeutic Intervention;therapeutic target;Time;Tissues;treatment strategy;Trees;Vascular blood supply;Vasoconstrictor Agents

PROJECT_TITLE: Astrocyte regulation of cerebral blood flow at the intersection of ischemia and Alzheimer's disease

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Narrative Recent years have shown that the structural dynamics of biomolecular systems is essential to biological actions and interactions in the cell, and it is critically important to identify the sites controlling the structural dynamics so as to design effective modulators of function and assess the impact of mutations. With this perspective, we aim to develop novel computational methods and tools to predict allosteric sites and essential mechanisms, assess the pathogenicity of point mutations, and assist in the design of effective intervention methods for modulating biological function and allo-targeting. These tools will be made accessible to the broader community through our widely used ProDy interface to enable effective usage and dissemination.

PI_NAMEs: BAHAR, IVET  (contact);DORUKER, PEMRA

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Address;Algorithms;Allosteric Site;Amino Acids;analytical method;application programming interface;Assessment tool;Attention;Benchmarking;Biological;Biological Process;Case Study;Cells;Collaborations;Communities;Complex;Computer Models;computerized tools;Computing Methodologies;computing resources;conformer;Crowding;Cryoelectron Microscopy;cryptic protein;Data;Data Set;Databases;design;Development;Dimensions;Discrimination;Distal;dynamic system;effective intervention;Elasticity;Elements;Event;experimental study;Family member;Four-dimensional;Frequencies;Goals;Grain;Growth;Human;Hybrids;improved;innovation;intermolecular interaction;Intervention;Laboratories;Learning;Letters;Libraries;Ligand Binding;Light;loss of function;machine learning algorithm;machine learning method;Maps;Mechanics;method development;Methodology;Methods;Modeling;Molecular;Molecular Conformation;molecular dynamics;Motion;multi-scale modeling;Mutation;network models;new technology;novel;Orthologous Gene;paralogous gene;Pathogenicity;Pathway interactions;Pattern;Performance;pharmacologic;Pharmacologic Substance;pharmacophore;Point Mutation;Productivity;Protein Dynamics;Protein Family;protein protein interaction;Proteins;Resources;response;Sampling;Scanning;simulation;Site;Solid;Structure;System;Technology;Tertiary Protein Structure;Testing;three dimensional structure;Time;tool;Translations;Validation;Variant;Work

PROJECT_TITLE: Toward  a  deeper  understanding  of  allostery  and  allotargeting  by  computational approaches

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: EXETER

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY OF EXETER

ORG_ZIPCODE: EX4 4QJ

PHR: Social modifiers of primate lifespan Social adversity is one of the strongest predictors of individual mortality, yet the extent to which the social environment determines how long humans and other primates live, and the molecular signatures of social aging and longevity remain unclear. This project investigates whether and why some primates live longer than others, and how social factors modify lifespans and the pace of molecular aging in a well-studied genera, the macaque. This work will help place human lifespans in the evolutionary, ecological, and social contexts from which they emerge, and will identify hypotheses about how modifiable social factors could effectively be deployed to improve health and wellbeing in aging primates, including, potentially, humans.

PI_NAMEs: BRENT, LAUREN JOHANNA NICOLE (contact);CHIOU, KENNETH LYU;ELLIS, SAMUEL ;SNYDER-MACKLER, NOAH

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Accounting;Affect;Age;Age Distribution;Aging;aging biomarker;aging clocks;aging process;Behavioral;biodemography;Biological;Blood;Body Size;Climate;comparative;Conflict of Interest;Data;Data Set;data sharing;Databases;Diet;Disease;DNA Methylation;epigenetic aging;epigenetic clock;Equity;extend lifespan;Generations;Genes;Genome;Health;Home;Human;improved;Individual;Infrastructure;Injury;insight;Length;Life Cycle Stages;life history;life span;Longevity;Longitudinal Studies;low socioeconomic status;Macaca;Modeling;Molecular;Molecular Profiling;mortality;Nature;Pathway Analysis;Pathway interactions;Personal Satisfaction;Persons;Population;Predatory Behavior;Primates;rate of aging;Research;Research Personnel;Resources;Risk;Sample Size;Sampling;Shapes;Skin;social;social adversity;social disparities;Social Environment;social factors;Social Impacts;Social isolation;Social Network;Social support;Socioeconomic Status;species difference;stem;structured data;System;Testing;trait;Variant;Violence;Work

PROJECT_TITLE: Social Modifiers of Primate Lifespan

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (M1)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: The involvement of practicing physicians, well-trained in research methodology, is critical for assuring clinical relevance and applicability of research findings. Lack of peer mentorship can be a significant barrier to a career as a clinician-scientist. This project builds a nationwide peer mentorship network for otolaryngologist-scientists that will support these important contributors to the research community and strengthen the diversity of the NIDCD research pipeline.

PI_NAMEs: NEWLANDS, SHAWN D. (contact);PICCIRILLO, JAY F.

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: academic program;Achievement;Address;Animals;Applications Grants;Area;aspirate;Award;career;Career Choice;Career Mobility;Clinical;clinical application;clinical practice;Clinical Research;clinically relevant;cohort;Communication;Communities;Country;Department chair;design;Development;Disparate;Disparity;Educational Materials;Ensure;Equilibrium;Evaluation;experience;experimental study;Faculty;Feedback;Funding;Genus Mentha;Goals;Grant;Grant Review;Group Meetings;health disparity;Health Services;Hearing;Immunology;improved;Individual;Infrastructure;innovation;Institution;interest;Maintenance;Malignant Neoplasms;Mediation;medical specialties;Medicine;meetings;member;Mentors;Mentorship;Mind;Mission;Modeling;Names;National Institute on Deafness and Other Communication Disorders;Occupations;Otolaryngologist;Otolaryngology;Outcome;Outcome Measure;outreach;peer;Persons;Physicians;Population Research;Program Evaluation;programs;recruit;Research;Research Methodology;Research Personnel;Research Technics;Research Training;Resources;response;Role;Running;Scientist;Secure;skills;Smell Perception;Societies;Speech;Structure;success;Surgeon;System;Time;Time Management;Training;United States National Institutes of Health;virtual;Walking;web site;Work

PROJECT_TITLE: Neely National Physician-Scientist Mentorship Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Z (43)]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE There is an urgent, unmet public health need to improve outcomes for chronic lung diseases, which disproportionately impacts the Southeast. This program will provide research training for investigators who will ultimately improve the healthcare and outcomes for individuals with lung diseases with particular emphasis on lung cancer prevention, screening and implementation, critical care, telehealth, and rare lung diseases, including pulmonary fibrosis, sarcoidosis and cystic fibrosis. Training in innovation and entrepreneurship will enable investigators to create innovative solutions to challenges in health, to catalyze interdisciplinary entrepreneurial efforts, and ultimately become change agents to address national and global health problems.

PI_NAMEs: FEGHALI-BOSTWICK, CAROL A. (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Foundations;innovation;Lung;Scholarship

PROJECT_TITLE: Pulmonary Focused Foundations in Innovation and Scholarship (PuFFInS)

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM (JA)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative Brain temperature regulation is a crucial hemodynamic parameter particularly after ischemia or brain injury. Currently, we have limited methods to measure and predict brain temperature in the clinical setting. Our goal is to develop a new method for non-invasive brain temperature monitoring, combined with a simulated model to enable brain temperature predictions, validated in healthy volunteers and patients with chronic cerebrovascular disease.

PI_NAMEs: FLEISCHER, CANDACE C. (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: 3-Dimensional;Address;Adherence;Anatomy;Animal Model;Biological Markers;Biomedical Engineering;biophysical model;Biophysics;Blood flow;blood treatment;Body Temperature;Brain;Brain Injuries;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular reactivity;Chemicals;Chronic;Clinical;clinical application;clinical decision-making;clinical development;cohort;Complement;Data;Disease;Dissociation;Empiricism;Engineering;Environment;Evaluation;Goals;healthy volunteer;Heart Arrest;hemodynamics;Heterogeneity;High temperature of physical object;Human;Human Volunteers;Impairment;Implant;improved;in vivo;Infarction;Injury;injury recovery;innovation;insight;Ischemia;ischemic injury;Ischemic Stroke;Knowledge;Liquid substance;Location;Magnetic Resonance;Mammals;Measurement;Measures;Methods;Modeling;Monitor;Morphologic artifacts;Morphology;mortality;mouse model;natural hypothermia;nerve injury;Nervous System Physiology;neural;neurological recovery;Neurology;neuroprotection;nonhuman primate;novel;novel strategies;Operative Surgical Procedures;Patient-Focused Outcomes;Patients;physical property;Physiologic Thermoregulation;porcine model;post stroke;predictive modeling;Predisposition;Prognosis;prognostic;Prognostic Marker;Recovery;Regulation;Reporting;Research;Research Project Grants;Resistance;response;Scanning;Scientist;Stroke;Structure;Temperature;Therapeutic;Thermometry;Tissues;tool;Traumatic Brain Injury;Validation;Work

PROJECT_TITLE: Synergistic advancements in MR thermometry and predictive thermal modeling towards improved characterization of human brain temperature

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Immunization;Vaccine Related

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Future advancements in our ability to develop, license and deploy effective vaccines against infectious and non- infectious diseases depend on advanced training of scientists in the multidisciplinary, rapidly evolving field of Vaccinology. This T32 Training Program in Vaccinology provides post-doctoral fellows with training in the performance of “bench” research and/or clinical studies and the analytical skills required to critically posit, evaluate, and advance focused and relevant scientific questions within the broad field of Vaccinology. Towards this goal, talented trainees receive exceptional academic support, research guidance, and mentoring from our dedicated faculty, as evidenced by the scientific and career successes of our prior trainees in the last two decades of this grant.

PI_NAMEs: SZTEIN, MARCELO B. (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TITLE: Fellowship Training Program in Vaccinology

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


PHR: Narrative Despite major advances in melanoma therapy, a major fraction of patients with advanced disease fail to respond adequately to therapy. This Program Project brings together highly collaborative studies focusing upon specific mechanisms underlying disease formation/progression and success or failure of these therapies, utilizing a collection of genetically defined preclinical animal models, and highly annotated melanoma patient biopsies. The Projects highlight key druggable pathways whose modulation profoundly alters the tumor microenvironment, rigorously assessing their mechanistic detail in stringent animal models, in advance of translating these opportunities into clinical trials.

PI_NAMEs: FISHER, DAVID E (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Active Sites;advanced disease;Advisory Committees;Animal Model;anti-CTLA4;anti-PD-1;Antigen Presentation;Antigens;arginine methyltransferase;Bar Codes;Bioinformatics;Biopsy;Budgets;cancer cell;CD8-Positive T-Lymphocytes;Cell Communication;Cell Physiology;Cells;checkpoint inhibition;Clinical Trials;Clonality;coactivator-associated arginine methyltransferase 1;Collection;Committee Members;Communication;Complex;Cross Presentation;cross reactivity;Cutaneous Melanoma;Data;Dendritic Cells;Development;Disease;Environment;Enzymes;Epigenetic Process;exhaust;exhaustion;Expenditure;Eye;Family;FDA approved;Genes;Genetic;Genetic Transcription;Genome;Grant;Growth;Hormones;Human;human tissue;Image;Imaging technology;Immune;immune checkpoint;Immune Evasion;Immunity;immunogenic;immunogenicity;immunoregulation;Immunotherapy;improved;in vivo;inhibitor;Interferon Activation;Interferons;Journals;Knock-out;Logistics;Malignant Neoplasms;Mediating;Mediator;meetings;melanocyte;Melanoma;Melanoma Cell;Melanoma patient;MHC antigen;Modeling;Molecular;Mutation;Names;Nature;neoplasm immunotherapy;Nodal;novel;Nuclear;Oncogenic;Oncoproteins;operation;Paper;Pathology;Pathway interactions;Patients;Peptide Hydrolases;Peptide/MHC Complex;Peptides;Pharmaceutical Preparations;pharmacologic;Phenotype;pre-clinical;Predisposition;pressure;Productivity;programs;Property;Proteins;Publications;Publishing;Quality Control;Regulation;Reporter;Research;Research Personnel;Resistance;response;Role;Science;Signal Pathway;Signal Transduction;single-cell RNA sequencing;success;System;T-Cell Activation;T-Lymphocyte;Technology;Testing;Therapeutic;therapeutic target;therapy resistant;Thermodynamics;Tissue Sample;tool;Transcription Coactivator;transcriptomics;Transforming Growth Factor beta;Translating;translational potential;Treatment Failure;Treatment outcome;treatment response;tumor;Tumor Immunity;tumor microenvironment;tumor progression;tumorigenesis;Validation;Visualization;Zebrafish

PROJECT_TITLE: Targetable epigenetic and transcriptional mechanisms in melanoma thatshape the microenvironment

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-F (M1)]


NIH_SPENDING_CATS: Cancer;Genetics;Skin Cancer

PHR: The administrative core ensures the successful administration of the PPG by providing: (1) leadership, oversight and cohesiveness, (2) communication and dissemination of information for maximal interdisciplinary collaborative research, and (3) management and fiscal oversight. In addition, the administrative core guarantees that the PPG meets its overall goals and complies with all institutional, governmental, and NIH regulations and policies.

PROJECT_TERMS: Acceleration;Accounting;Administrator;Advisory Committees;Bioinformatics;Biology;Boston;Collaborations;collaborative environment;Committee Members;Communication;Communities;Computer software;Cutaneous;Dana-Farber Cancer Institute;Development;Doctor of Medicine;Doctor of Philosophy;Ensure;Environment;Epigenetic Process;Expenditure;Financial Support;Fostering;Funding;General Hospitals;Genetic Transcription;Goals;Grant;Hospitals;Human Resources;Information Dissemination;Institution;instrumentation;Joints;Laboratories;laboratory experience;Leadership;Massachusetts;meetings;Melanoma;Monitor;Pathology;Pediatric Hospitals;Performance;Policies;Preparation;Productivity;Program Research Project Grants;programs;Progress Reports;Regulation;Research;Research Ethics;Research Personnel;Resources;scientific organization;Scientist;skills;Structure;Supervision;Technology;tool;training opportunity;Translational Research;United States National Institutes of Health;Woman

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Human Genome;Immunotherapy;Skin Cancer

PHR: Narrative Project 1 examines the role of DDI2 as regulator of a pathway that suppresses levels of MHC- antigen presentation complexes at the tumor surface, thereby promoting immune evasion. Because DDI2 is transcriptionally targeted by the melanoma oncoprotein MITF, we will test the hypothesis that the MITF-DDI2 axis represents a novel oncogenic immune modulation mechanism. We will also scrutinize the antigenic repertoire regulated by DDI2 via immunopeptidomics to test the hypothesis that pharmacologic DDI2 suppression would stimulate both quantity and diversity of presented antigens by melanoma cells.

PROJECT_TERMS: Active Sites;anti-CTLA4;anti-PD-1;Antigen Presentation;antigen-specific T cells;Antigens;Bioinformatics;Biological Assay;CD4 Positive T Lymphocytes;CD8B1 gene;cell killing;Cells;chromatin remodeling;Clinical;clinical translation;Collaborations;Complex;contextual factors;Coupled;Data;Development;Drug Targeting;Enzymes;Epigenetic Process;FDA approved;Genes;Genetic Transcription;Goals;HIV Protease Inhibitors;HIV-1 protease;Human;Immune;Immune checkpoint inhibitor;Immune Evasion;Immunofluorescence Immunologic;immunogenicity;Immunophenotyping;immunoregulation;Immunotherapy;In Vitro;in vivo;Knock-out;knockout gene;Link;Melanins;melanocyte;Melanoma;Melanoma Cell;MHC antigen;MHC Interaction;Modeling;Molecular;mouse model;Mus;Mutate;Nelfinavir;neoplastic cell;novel;Oncogenes;Oncogenic;Oncoproteins;Pathology;Pathway interactions;Patients;Peptide Hydrolases;Peptide/MHC Complex;Peptides;Pharmaceutical Preparations;pharmacologic;Phenocopy;Pigmentation physiologic function;Pigments;Population;pre-clinical;Process;Protease Inhibitor;protein aggregation;protein expression;protein misfolding;protein protein interaction;Proteins;Proteomics;Quality Control;Regulation;Resistance;response;RNA;Role;single-cell RNA sequencing;Skin tanning;Solid Neoplasm;Surface;T cell receptor repertoire sequencing;T-Cell Activation;T-cell diversity;T-Lymphocyte;Testing;therapeutic target;therapy resistant;Thermodynamics;transcription factor;Transcription Factor Oncogene;Transcriptional Regulation;Treatment Efficacy;Treatment outcome;tumor;tumor microenvironment;tumor progression;tumor-immune system interactions;tumorigenesis;Up-Regulation;UV induced;virtual

PROJECT_TITLE: Remodeling Chromatin and the Tumor Microenvironment: Direct Oncogenesis and Therapeutic Targeting


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Skin Cancer

PHR: Project Description We have developed a system to study how multiple growth factor signals are interpreted by cancer cells and their niche in vivo. We also have developed cellular barcoding methods to examine the clones of cancers cells that are most hurting the patient at a particular time. The ability to examine the spatial signals and clones will potentially lead to new therapies.

PI_NAMEs: ZON, LEONARD IRA (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Area;Bar Codes;Blood;cancer cell;cancer drug resistance;cancer imaging;CD8-Positive T-Lymphocytes;Cell Communication;Cell Physiology;cell type;Cells;Chromatin;Clinical;Clonal Evolution;Clonal Expansion;Clonality;Clustered Regularly Interspaced Short Palindromic Repeats;Color;Complex;Coupled;Dendritic Cells;DNA;DNA sequencing;driving force;Drug resistance;Eating;Ecosystem;Endothelial Cells;Epigenetic Process;Evolution;exhaust;extracellular;Fibroblasts;Fishes;Gene Expression;Genetic Transcription;Genotype;Growth;Growth Factor;Hour;Human;IL8 gene;Image;Immune;in vivo;in vivo fluorescence imaging;interest;Interferon Type I;Interferons;Investigation;Label;Macrophage;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;Membrane Proteins;Methods;Mitochondria;Mitochondrial DNA;multiplexed imaging;Mutate;neoplastic cell;novel therapeutics;Outcome;overexpression;Pathway interactions;Patients;Play;Population;Reporter;response;Role;Sampling;Signal Transduction;single cell analysis;single cell ATAC-seq;Stromal Cells;Surface;System;T cell infiltration;T cell receptor repertoire sequencing;T-Lymphocyte;Technology;TGF Beta Signaling Pathway;therapy resistant;Time;Tissues;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;Transgenic Organisms;tumor;tumor heterogeneity;tumor progression;WNT Signaling Pathway;Work;Zebrafish

PROJECT_TITLE: Transcriptional mechanisms and melanoma


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Skin Cancer

PHR: Narrative This project focuses on a novel epigenetic target for immunotherapy of melanoma, the CARM1 enzyme. We will investigate how inhibition of this enzyme enhances the function of dendritic cells and T cells in the immune response against melanoma.

PI_NAMEs: WUCHERPFENNIG, KAI W (contact)

PROJECT_TERMS: Affinity;Alleles;anti-melanoma immunity;Antigen Presentation;Antigens;Apoptotic;Arginine;arginine methyltransferase;arm;ATAC-seq;Attenuated;Autologous;Binding;cancer infiltrating T cells;CD8-Positive T-Lymphocytes;Cell Line;Cell Physiology;Cells;Chromatin;Chronic;Clinical;coactivator-associated arginine methyltransferase 1;Coculture Techniques;Collaborations;conditional knockout;CRISPR screen;Cross Presentation;Cytosol;cytotoxic;Data;Dendritic Cells;design;Disease;draining lymph node;Effector Cell;Enhancers;Enzyme Inhibition;Enzymes;Epigenetic Process;exhaustion;Functional impairment;Gene Expression;Generations;Genes;Genetic Screening;Genetic Transcription;Growth;Histone H3;Human;Human Activities;Immune;immune checkpoint blockade;Immune response;Immunity;Immunotherapy;improved;In Vitro;in vivo;Infiltration;inhibitor;interest;Knockout Mice;LoxP-flanked allele;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Melanoma;Melanoma Cell;Melanoma Vaccine;Methylation;Modeling;Molecular;mouse model;multicatalytic endopeptidase complex;Mus;neoplastic cell;novel;novel strategies;Nuclear Hormone Receptors;Pathogenicity;Pathway interactions;Patients;PD-1 blockade;Peptides;Play;Population;Process;Proliferating;promoter;Proteins;receptor;Resistance;Role;sensor;Sentinel;single-cell RNA sequencing;small molecule inhibitor;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Transcription Coactivator;transcription factor;transcriptome sequencing;Transgenic Mice;tumor;Tumor Antigens;tumor microenvironment;Up-Regulation;uptake;Zebrafish

PROJECT_TITLE: The Epigenetic Enzyme CARM1 as a Negative Regulator of Dendritic cells and CD8 T cells in Melanoma


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Skin Cancer

PHR: Project Narrative The Pathology and Bioinformatics Core will serve as a crucial resource for the Program to investigate melanoma signaling networks governing immune evasion and response by providing Investigators with expertise and infrastructure to ensure experimental approaches are soundly designed, implemented, and executed. The efforts of the Core will also ensure that findings made in the individual Projects are integrated into broader conclusions on the signaling networks of melanoma, with particular emphasis on the tumor-immune microenvironment.

PI_NAMEs: RODIG, SCOTT J (contact)

PROJECT_TERMS: animal tissue;Architecture;biobank;Biocompatible Materials;Bioinformatics;Biological Assay;Biological Markers;biomarker development;Biopsy Specimen;Cell Communication;Clinical;computerized tools;Data;data integration;Data Set;design;Development;Ensure;Epigenetic Process;Equipment;Expert Opinion;Genetic Transcription;Genomics;Goals;Histopathology;human tissue;Immune;Immune Evasion;Immune response;Immune signaling;Individual;Infrastructure;inter-institutional;large datasets;Melanoma;Methods;Modeling;Molecular;novel;Pathologic;Pathology;programs;Quality Control;Research;Research Design;Research Personnel;Resources;Sampling;Services;Signal Pathway;Signal Transduction;sound;Source;Statistical Data Interpretation;synergism;Techniques;tissue biomarkers;Tissue Sample;Tissues;transcriptomics;tumor;tumor-immune system interactions;Work

PROJECT_TITLE: Pathology and Bioinformatics Core


ADMINISTERING_IC: DK

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Narrative Zinc dyshomeostasis is implicated in the elderly population and Alzheimer’s disease (AD). ApoE4 is the strongest genetic risk factor in AD, and Zinc-APOE4 interaction and resulted toxicity in the central nervous system (CNS) is unclear. New information obtained from this study may lead to novel strategies for targeting zinc dyshomeostasis and its interaction with APOE4 as potential treatment of AD.

PI_NAMEs: QIN, YI-XIAN ;ZHU, DONGHUI  (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: abeta accumulation;abeta oligomer;Accounting;Address;Administrative Supplement;Adverse effects;Affect;Affinity;aging population;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Animal Model;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Apoptosis;Apoptotic;Area;Astrocytes;Attenuated;Automobile Driving;Binding;Biological Assay;Brain;brain cell;brain endothelial cell;Brain-Derived Neurotrophic Factor;Caspase;Cell Death;Cell Line;Cell Physiology;Cell Survival;cell type;Cells;Central Nervous System;cerebrovascular;Chelating Agents;chelation;Clinical Trials;Copper;cytotoxicity;Dementia;Docking;Edetic Acid;Elderly;Exhibits;Frequencies;gain of function;Genes;genetic risk factor;glial activation;glial cell-line derived neurotrophic factor;Histocompatibility Antigens Class II;Human Biology;Immune;Incubated;Inflammation;Inflammatory;insight;Investigation;Ionophores;Ions;Knowledge;Measures;Mediating;Metals;Microglia;mitochondrial dysfunction;Molecular;Molecular Conformation;Mus;Nerve Degeneration;Nervous System;Nervous System Disorder;Neuroglia;Neurologic;neuron loss;Neurons;neurotoxic;neurotrophic factor;Nitric Oxide Synthase;novel;novel strategies;Pathogenesis;Pathway interactions;Patients;Pericytes;Persons;Population;Precipitation;Prevalence;Process;Protein Isoforms;Proteins;Risk;Role;Senile Plaques;Spectrum Analysis;Surface Plasmon Resonance;tau aggregation;Testing;Therapeutic;Thinness;Toxic effect;Trace Elements;Traction;Zinc;Zinc deficiency

PROJECT_TITLE: Administrative Supplement: Zinc-APOE4 interaction and toxicity in the central nervous system (CNS)


NIH_SPENDING_CATS: Cancer

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: The Tumor Biology Training Program (TBTP) is designed to prepare the next generation of dynamic, diverse cancer researchers with lifelong learning skills so that they can make significant inroads into the understanding, prevention and treatment of cancer and to advance scientific knowledge so that all of our cancer patients can live longer and happier lives.

PI_NAMEs: RIEGEL, ANNA TATE;ROBBINS, DAVID J;YI, CHUNLING  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Grant;Training;Tumor Biology

PROJECT_TITLE: Training Grant In Tumor Biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-R (M1)]


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative There is a great need to increase the number and diversity of physician-scientists, who are uniquely positioned to translate cancer-related scientific discoveries directly to patients. This program seeks to increase the number and diversity of physician-scientists who are committed to investigative excellence in cancer-related research by providing early 2-year training experiences for undergraduate students.

PI_NAMEs: CHEN, HERBERT  (contact)

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: academic preparation;Achievement;Address;Admission activity;African American;Alabama;anti-cancer research;Area;Awareness;Basic Science;Calendar;Cancer Biology;Cancer Burden;cancer care;cancer genetics;Cancer Patient;cancer prevention;cancer therapy;cancer type;career;career development;Clinical;Collaborations;Communication;Communities;community engagement;Community Health;Community Outreach;Comprehensive Cancer Center;Dedications;design;Development;Diagnosis;Diagnostic;Disparity;dissemination strategy;Education;education research;Educational Curriculum;Educational workshop;Environment;Event;experience;Exposure to;Extramural Activities;Family;Foundations;Friends;Funding;Future;Goals;graduate school;Health Services;Individual;Infrastructure;Instruction;interest;Knowledge;Learning;Malignant Neoplasms;medical schools;meetings;member;Mentors;Mentorship;minority health;multidisciplinary;next generation;Oncology;oncology program;Operative Surgical Procedures;Outcome;outreach;Participant;Patients;Physician's Role;Physicians;Play;Population;Population Heterogeneity;Positioning Attribute;Prevention;Process;programs;Reduce health disparities;Research;research data dissemination;Research Personnel;Research Training;responsible research conduct;Role;Science;Scientist;Signal Transduction;skill acquisition;Students;success;summer research;Surgeon;symposium;Training;Training Programs;Translating;tumor immunology;Tumor Pathology;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Populations;Universities;university student;Youth

PROJECT_TITLE: FUture Surgeons and Scientists Investigating ONcology

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Infectious Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative Despite scientific advances in combating deadly infectious diseases and successes in treatment in developed countries, the world-wide death toll continues to rise because new diseases continue to emerge, drug resistance is increasing, and there are no effective vaccines for some of the deadliest diseases. To address these challenges, the Graduate Program in Tropical Infectious Diseases (GPiTID) is embedded in a school of public health but focuses on fundamental scientific discovery using cutting edge approaches of genomics, cell biology, immunology, population biology and gene editing, coupled with epidemiology of the diseases in their natural setting, to address major infections that pose a threat to public health both in the US and abroad. There is a focus on fundamental scientific training but in the context of the diseases as holistic problems and with an emphasis on fundamental discoveries that could lead to new interventions including drug, vaccine, and insecticide development.

PI_NAMEs: FORTUNE, SARAH ;KANKI, PHYLLIS J.;WIRTH, DYANN F (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Communicable Diseases;programs

PROJECT_TITLE: The Graduate Program in Tropical Infectious Diseases


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Our understanding of the neural basis of human cognitive abilities has been limited by opportunities and methods to record from populations of single neurons in the human prefrontal cortex. This work leverages recent advances in neurotechnology and opportunities to record from awake humans to study how populations of neurons in prefrontal cortex mediate human cognitive function. Using a unique neural probe that can record hundreds of neurons from a single shank, we will study executive function during awake deep brain stimulation surgeries.

PI_NAMEs: DENMAN, DANIEL JAMES;KRAMER, DANIEL R (contact);PAULK, ANGELIQUE C

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Address;Alzheimer's Disease;Animal Model;Area;awake;Cognition;Cognition Disorders;Cognitive;cognitive ability;cognitive function;Complex;Conflict (Psychology);conflict resolution;Cortical Column;Deep Brain Stimulation;Dimensions;Disease;effective intervention;Electrodes;Electrophysiology (science);executive function;Exhibits;feature selection;flexibility;Functional disorder;Geometry;Goals;Human;Image;implantation;information processing;Joints;Knowledge;Measures;Mediating;Methods;Middle frontal gyrus structure;Motor Cortex;Nature;neocortical;neural;Neurons;neurotechnology;novel;Operative Surgical Procedures;Participant;participant enrollment;patient engagement;Patients;Penetration;Population;population based;Population Dynamics;Prefrontal Cortex;Process;Research;Resolution;response;selective attention;Sensory;sensory cortex;sensory input;severe injury;Short-Term Memory;Site;Source;Structure;System;Technology;Testing;Therapeutic Intervention;tool;Traumatic Brain Injury;Work

PROJECT_TITLE: Neocortical microarchitecture of executive function using large-scale intracranial electrophysiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-P (14)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative In response of RFA-AG-24-018, we propose to develop a biologically relevant multi-scale model of brain aging using advanced yet clinically feasible diffusion MRI, which holds enormous untapped potential to bridge the meso-macro gap and disentangle the extent of neuro-inflammation and neurodegeneration in aging and the onset of Alzheimer’s disease (AD) and AD related dementias (ADRD). We will create in vivo brain charts of quantitative diffusion MRI and white matter microstructure markers across the life-span, in order to create a novel brain aging framework and validate it using histopathology and proteomics on postmortem brain samples, as well as by longitudinal follow-up MRI and comparison against conventional structural MRI. This brain microstructure age framework will provide meaningful insight into the microstructural processes underlying brain aging and AD/ADRD and enable quantitative assessment of treatment response to future symptomatic and disease-modifying therapies.

PI_NAMEs: FIEREMANS, ELS  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Acceleration;Age;age related deterioration;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Astrocytosis;Autopsy;axonal degeneration;biological age;Brain;Brain scan;brain volume;Centenarian;Clinical;cohort;Collection;Data;Data Set;Dementia;Demyelinations;Deterioration;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Dimensions;Disease;Disease Progression;Electronic Health Record;Ethnic Origin;Evaluation;follow-up;Functional disorder;Future;Genetic;Gliosis;gray matter;Health;healthy volunteer;Histopathology;Human;Image;image processing;Impaired cognition;in vivo;indexing;Individual;Infiltration;insight;life span;Life Style;lifestyle factors;Macrophage;Magnetic Resonance Imaging;Measures;Mediating;meter;Methods;millimeter;Modeling;modifiable risk;Molecular;Monitor;MRI Scans;multi-scale modeling;multidisciplinary;Nerve Degeneration;neuroimaging;neuroinflammation;neuropathology;novel;open source;Parameter Estimation;Pathologic;Pathologic Processes;Pathology;Patients;Phase;Preventive measure;Process;Proteomics;Protocols documentation;Race;Research;research study;Resolution;response;Risk;Risk Factors;Role;Sampling;Scanning;Series;sex;Source;Specificity;Specimen;Staging;Structure;tau Proteins;Time;treatment response;Validation;water diffusion;white matter;Work

PROJECT_TITLE: Multiscale Modeling of Brain Aging and Alzheimer’s Disease with MRI, Pathology and Proteomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-2 (M2)]