NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Psychosis;Serious Mental Illness;Social Determinants of Health

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Charting mental illness trajectories to determine when, where, and how to intervene is a key  objective of the NIMH mission to transform the understanding and treatment of mental illness. This  project will: (1) deepen our understanding of the trajectory leading to hospitalization discharge  with knowledge about behavioral biomarkers and their relationship to symptoms and  discharge-readiness; (2) contribute to the knowledge on how social context impacts patient's  behaviors since some symptoms or predictive biomarkers may only be seen in a specific context such  as social or solitary interactions; and (3) contribute a credible, objective framework for  behavioral measurement by defining interpretable biomarkers and latent factors for symptoms and  discharge assessment. The project will also enable a judicious use of remote sensing and non-direct  clinical encounters (e.g., telemedicine), which are increasingly viewed as essential capabilities  in the medical fields to reduce costs while maintaining or elevating care standards.

PI_NAMEs: BAKER, JUSTIN T (contact);DE LA TORRE, FERNANDO

PROGRAM_OFFICER_NAME: FERRANTE, MICHELE

PROJECT_TERMS: acceptability and feasibility;Address;Behavior;behavior measurement;Behavioral;behavioral health;Biological Markers;biomarker development;care delivery;Caring;Chronic Disease;Clinical;clinical care;clinical decision-making;clinical encounter;clinical practice;Clinical Research;Complex;computer framework;Computer software;cost;Data;Data Set;Dependence;Development;Diagnostic;Discharge Plannings;Disease;Ensure;Equipment;fundamental research;Goals;health assessment;Healthcare;Healthcare Systems;Hospitalization;Hospitals;Human;improved;Individual;Informatics;Inpatients;insight;Interview;Judgment;Knowledge;Linear Models;longitudinal dataset;Measurement;Measures;Medical;Mental disorders;Mental Health;Mental Health Services;Methods;Mission;Modality;Modeling;Monitor;multimodality;Names;National Institute of Mental Health;neural model;non-verbal;novel;novel strategies;Outcome;Patients;Population;predict clinical outcome;predictive marker;Process;prognostic;Protocols documentation;provider behavior;Proxy;psychiatric symptom;Psychiatry;Psychotic Disorders;Readiness;remote sensing;Research;Resource Allocation;scaffold;Self Perception;severe mental illness;Shapes;social;Social Environment;Symptoms;System;Technology;Telemedicine;Testing;Time;trustworthiness;Universities;Validation;Work

PROJECT_TITLE: SCH: INT: Collaborative Research: Context-Adaptive Multimodal Informatics for Psychiatric Discharge Planning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MOSS-V(50)]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative  The goals of this project are to collect data in the 2023 wave of the Panel Study of Income Dynamics on three continuing modules—family dynamics, fertility and newborns, and education—and to design and collect enhanced information on fertility intentions and new data on contraceptive use, as well as to clean, document, distribute, and promote these data.

PI_NAMEs: MCGONAGLE, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Adolescence;Adoption;Adult;Area;Behavior;Behavioral Research;Birth;Book Chapters;Books;Charge;Child;child bearing;Child Development;Childhood;cohort;Collection;Complex;Consumption;Contraceptive methods;Contraceptive Usage;cost effectiveness;COVID-19 impact;COVID-19 pandemic;Data;data archive;data centers;Data Collection;Data Set;Data Sources;Decision Making;design;distributed data;Economics;Education;Exercise;experience;Family;Family dynamics;Family Process;Family Study;Fertility;Funding;Generations;Genetic Markers;Goals;Grant;Health;Health behavior;health disparity;Health Status;Household;Immigrant;Income;innovation;intergenerational;Internet;Investments;journal article;Life;Life Cycle Stages;Life Experience;Living Arrangement;Marriage;Measurement;migration;Modeling;National Institute of Child Health and Human Development;Neighborhoods;Newborn Infant;Obesity;offspring;Outcome;outreach;pandemic disease;panel study of income dynamics;Personal Satisfaction;Policies;Poverty;Process;Research;Research Personnel;Research Support;response;Running;Sampling;SARS-CoV-2 exposure;Savings;Schools;Science;Scientist;Shapes;Shock;Smoking;social;Social Sciences;Socioeconomic Status;Surveys;Teenagers;Telephone;Time;transition to adulthood;transmission process;Wages;young adult

PROJECT_TITLE: Family Dynamics, Fertility and Contraception, and Investments in Children across Generations

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Single important nucleotide polymorphisms (SNPs), the most common type of human genetic variants, play roles in shaping complex human traits and causing diseases, andadvancements in high-throughput technologies have enabled researchers to generate multiple types of omics data used in the identification and analyses of these SNPs. Our group constructed a series of data portals for molQTLs, including data portals for expression QTLs (eQTLs), methylation QTLs (meQTLs), and splicing QTLs (sQTLs) based on a large number of patient samples, and these related data resources have been broadly accessed since their releases. The goal of this proposal is to enhance, expand, and promote our existing data resources that will bridge the genetic variants and different molecular features through molQTL analysis, providing a unique data resource for understanding the functional effects of genetic variants and facilitating access to and understanding of complex datasets for non-expert users.

PI_NAMEs: HAN, LENG  (contact)

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TERMS: Antineoplastic Agents;Arthritis;biobank;cancer type;Categories;causal variant;Clinical;Clinical Trials;Communities;Complex;complex data;CRISPR/Cas technology;Data;data portal;data resource;Data Set;database of Genotypes and Phenotypes;Deposition;Disease;disorder risk;Educational workshop;Epigenetic Process;Event;genetic architecture;Genetic Polymorphism;genetic variant;genome editing;genome wide association study;Genomics;Genotype;Goals;Heart Diseases;high throughput technology;Human;Human Genetics;Immune;Individual;Investigation;Link;Linkage Disequilibrium;Malignant Neoplasms;Maps;Mediation;metabolomics;Methylation;microbiome;Molecular;molecular phenotype;multidimensional data;Multiomic Data;novel;novel diagnostics;novel therapeutic intervention;Nucleotides;online resource;Patients;Pharmaceutical Preparations;phenotypic data;Play;Polyadenylation;Post-Transcriptional Regulation;precision medicine;prognostic;Proteins;Proteomics;Quantitative Trait Loci;Research;Research Personnel;Resources;response;Risk;RNA Editing;RNA Splicing;Role;Sampling;Series;Shapes;Single Nucleotide Polymorphism;Statistical Methods;Technology;The Cancer Genome Atlas;therapeutic target;trait;Translating;translational medicine;translational potential;Untranslated Regions;Untranslated RNA;Update;user-friendly;Variant;Writing

PROJECT_TITLE: MolQTL: A comprehensive resource for molecular quantitative trait loci inhuman cancer.

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Prostate Cancer;Urologic Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: NARRATIVE Advanced prostate cancer remains an incurable disease that often colonizes the skeleton, causing bone destruction and pain. Drugs used to mitigate bone destruction can induce changes in bone metastatic prostate cancer cells that, in turn, attract and activate specific immune cells (γδ T cells). Based on this observation, we propose to study 1) how prostate cancer cells and bone microenvironmental cells namely, mesenchymal stromal cells (MSCs), affect the activity of γδ T cells; 2) how γδ T cells can be manipulated to make them more effective cancer killers by introducing cancer-specific chimeric antigen receptors; and 3) how γδ T cells modify the bone microenvironment response; with the long-term goal of developing novel and more effective immunotherapies for prostate cancer.

PI_NAMEs: ABATE-DAGA, DANIEL  (contact)

PROGRAM_OFFICER_NAME: SALOMON, RACHELLE

PROJECT_TERMS: Acute;Adoptive Transfer;advanced prostate cancer;Affect;Anatomy;androgen deprivation therapy;androgen independent prostate cancer;anti-cancer;Antigen Targeting;Antigens;antitumor effect;Apoptosis;Apoptotic;Attention;Autologous;Binding;Biological Availability;Biological Testing;bisphosphonate;bone;Bone Diseases;Bone Marrow;Bone Matrix;cancer cell;Cancer Patient;CAR T cell therapy;carcinogenesis;Castration;CD28 gene;CD3 Antigens;CD8B1 gene;Cell Differentiation process;Cell Line;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Trials;CTLA4 gene;CWR22Rv1;Cytokeratin;Cytokine Receptors;cytotoxic;cytotoxicity;Data;design;Deterioration;Disease;Drug usage;early phase clinical trial;Effectiveness;Engineering;enhancing factor;experimental study;Flow Cytometry;Frustration;Generations;Genetic;genetically modified cells;Goals;Growth;Histologic;Homing;Human;Immune;immune checkpoint blockade;Immunocompetent;Immunotherapy;In Vitro;in vitro testing;in vivo;indexing;Infiltration;insight;isopentenyl pyrophosphate;Luciferases;luminescence;Malignant Bone Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Membrane;men;mesenchymal stromal cell;Metastatic Prostate Cancer;microSPECT;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;mouse model;Mus;Myeloid Cells;neoplastic cell;novel;novel strategies;Osteoblasts;Osteoclasts;Osteogenesis;osteogenic;overexpression;Pain;patient derived xenograft model;Patients;Performance;pharmacologic;Phenotype;phosphoproteomics;Physiology;pre-clinical;prevent;Process;Production;programmed cell death ligand 1;Property;prostate cancer cell;prostate stem cell antigen;Randomized;Reagent;recruit;Regulatory T-Lymphocyte;Resolution;response;Roentgen Rays;Safety;Signal Pathway;Signal Transduction;Site;Skeleton;Solid;Stains;Structure;subcutaneous;success;T-Cell Receptor;T-Cell Receptor Therapy;T-Lymphocyte;T-Lymphocyte Subsets;targeted cancer therapy;Techniques;Testing;Therapeutic Effect;Time;Tissues;Toxic effect;Translations;Transmembrane Domain;Treatment Efficacy;tumor;Tumor Antigens;tumor growth;tumor microenvironment;tumor progression;Xenograft Model;Zoledronate;γδ T cells

PROJECT_TITLE: Understanding the influence of bone-metastatic prostate cancer and mesenchymal stromal cells on γδ T cells, in the bone microenvironment.

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Asthma;Genetics;Lung

ORG_CITY: DURHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Relevance  This project is relevant to public health because it has a high likelihood of finding new, or improving current, asthma medications. Furthermore, the results could alter our understanding of beta-2-adrenergic receptor function in asthma at a paradigm-shifting level. Finally, the signaling pathways and ligands we reveal in this project could be highly applicable to drug discovery for many other diseases.

PI_NAMEs: CHU, HONG W;DICKEY, BURTON F;PENN, RAYMOND B.;WALKER, JULIA K L (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Ablation;Address;Adrenal Cortex Hormones;Agonist;airway epithelium;airway hyperresponsiveness;airway inflammation;Allergens;Allergic;ARRB2;Arrestins;Asthma;asthma model;asthmatic;Basic Science;beta-2 Adrenergic Receptors;beta-arrestin;Biology;Bronchodilation;Cell Physiology;cell type;Cells;Clinic;Clinical Research;Collaborations;Complex;cytokine;desensitization;Deterioration;Disease;disease model;drug discovery;epidemiology study;Epithelial Cells;Epithelium;Failure;G-Protein-Coupled Receptors;Genes;Genetic;genetic regulatory protein;GTP-Binding Proteins;Hand;Human;human subject;immunoregulation;improved;in vivo;Inflammation;Inflammatory;Interleukin-13;Knock-out;Knockout Mice;Ligands;Lung;Mechanics;Mediating;Modeling;Molecular;mortality;mouse model;Mucous body substance;Mus;Muscle Contraction;NIH Program Announcements;novel;Pathology;permissiveness;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenotype;Physiological;Physiology;pre-clinical;Prophylactic treatment;protective effect;Public Health;Pulmonary Inflammation;receptor function;Research;respiratory smooth muscle;Safety;scaffold;Series;Signal Pathway;Signal Transduction;Signaling Protein;System;Tachyphylaxis;Testing;Therapeutic;Translational Research;Universities;Work

PROJECT_TITLE: Novel Biased Beta2-AR Ligands as Asthma Therapeutics

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: In a subset of diseases called myeloproliferative neoplasms (MPN), mutations of a protein called calreticulin cause abnormalities in bone marrow cells and aberrant production of platelets from their precursor cells. Mechanistically, the mutations affect calcium handling by cells, induce aberrant interaction with a growth factor receptor to amplify cell proliferation, and also negatively influence key immune system processes to help abnormal cells evade the immune response. Understanding these processes could elucidate new pathways to combat MPN, and thus the proposed research contributes to the mission of the NIH relating to advancement of fundamental knowledge to reduce the burden of human disease and disability.

PI_NAMEs: RAGHAVAN, MALINI  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Abnormal Cell;Address;Affect;Affinity;Alleles;Antigen Presentation;Antigen-Presenting Cells;Antigens;Apoptotic;Base Pairing;Binding;Binding Proteins;Binding Sites;Blood Platelets;Bone Marrow;Bone Marrow Cells;C-terminal;Calcium;Calcium Binding;Calcium Signaling;calreticulin;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Maturation;Cell Proliferation;Cell secretion;Cell surface;cell transformation;Cells;Charge;Chronic;combat;Complex;Dendritic Cells;Dependence;dimer;disability;Disease;disulfide bond;Disulfides;driver mutation;Endoplasmic Reticulum;Environment;Fibrosis;Frameshift Mutation;Genes;Globulins;Glycoproteins;Growth Factor Receptors;Health;Hemorrhagic Thrombocythemia;Homeostasis;Human;human disease;Hyperplasia;Immune Evasion;Immune response;Immune system;Immunity;Immunologics;Immunotherapeutic agent;Impairment;Induced Mutation;Infection;Inflammation;insertion/deletion mutation;insight;Knowledge;leukemia;Light;Link;lysyl-aspartyl-glutamyl-leucine;Major Histocompatibility Complex;Malignant Neoplasms;Measures;Mediating;Mediator;Megakaryocytes;Mission;Molecular;Molecular Chaperones;monocyte;MPL gene;Mutagenesis;mutant;Mutate;Mutation;Myelofibrosis;Myeloproliferative disease;Nature;neoantigens;neoplasm immunotherapy;novel;Oncogenic;Pathway interactions;Patients;peptide I;Peptides;Phagocytosis;Phagocytosis Induction;Phosphatidylserines;precursor cell;Primary Myelofibrosis;Process;Production;protein activation;protein folding;Proteins;Recurrence;Research;response;Sampling;Site;Somatic Mutation;Specificity;Splenomegaly;T cell response;tool;United States National Institutes of Health

PROJECT_TITLE: Calreticulin-mediated protein folding in health and disease

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases;West Nile Virus;Zika Virus

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Dengue virus (DENV) and related flaviviruses are pathogens of high biomedical significance against which we lack effective countermeasures. Building on our prior work, we will optimize small molecule inhibitors of the viral envelope protein and demonstrate antiviral efficacy in vivo. Our goal is to establish the proof of concept needed to develop direct-acting antiviral drugs targeting E.

PI_NAMEs: GRAY, NATHANAEL SCHIANDER;YANG, PRISCILLA LI-NING (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Address;ADME Study;Animal Model;Anti-viral Agents;anti-viral efficacy;antiviral drug development;aqueous;Automobile Driving;Binding;Binding Proteins;Binding Sites;Biochemical;Biological Assay;Biology;Chemicals;combat;Complex;Computational Biology;Computer Analysis;Computer Models;Culicidae;cytotoxicity;Dengue Infection;Dengue Virus;design;Disease;Docking;Drug Design;Drug Kinetics;Drug Targeting;E protein;efficacy testing;emerging virus;Engineering;env Gene Products;Enzymes;Evaluation;experimental study;extracellular;Flavivirus;flavivirus glycoprotein E;Foundations;Future;Glucosides;Goals;high throughput screening;human pathogen;Immune response;Immunity;in silico;In Vitro;in vivo;in vivo evaluation;in vivo Model;Infection;inhibitor;Japanese encephalitis virus;Kinetics;Lead;lead optimization;lead series;Libraries;Liposomes;Maximum Tolerated Dose;Measures;Mediating;Membrane Fusion;Microsomes;Minority;Modeling;mouse model;mutant;novel therapeutics;particle;pathogen;Peptide Hydrolases;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phenotype;Plasma Proteins;Polymerase;process optimization;Property;prophylactic;Proteins;Public Health;Recombinants;Resistance;resistance mutation;Resistance profile;Resources;screening;Serial Passage;Series;Serotyping;Site;Site-Directed Mutagenesis;small molecule;small molecule inhibitor;Solubility;structural biology;Structural Models;Structure;Therapeutic;Time;transmission process;Viral;viral entry inhibitor;Viral Envelope Proteins;viral resistance;Viremia;Virion;Virus;Virus Inhibitors;West Nile virus;Work;X-Ray Crystallography;ZIKA;Zika Virus

PROJECT_TITLE: Validating the Flavivirus Envelope Protein as an Antiviral Target

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Cardiovascular;Clinical Research;Health Services;Heart Disease;Networking and Information Technology R&D (NITRD);Prevention;Telehealth

ORG_CITY: NASHVILLE

ORG_NAME: VOLUMETRIX, LLC

ORG_STATE: TN

PHR: Project Narrative Decompensated HF is the leading cause of hospitalization. HF leads to water accumulation in the tissues (lungs and legs) resulting in shortness of breath and leg swelling. This project will advance the development of an accurate, inexpensive, easy to use device (“NIVAHF”) for volume measurements in patients with HF. Use of these devices will ultimately help health care providers and patients prevent water overload. The long-term goal is to prevent costly hospital readmissions, improve quality of life, and reduce mortality in patients with HF.

PI_NAMEs: HOCKING, KYLE MITCHELL (contact);LINDENFELD, JOANN

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Academic Medical Centers;Advanced Development;Algorithm Design;Android;Awareness;Blood capillaries;Breakthrough device;Cardiac Catheterization Procedures;Categories;Certification;Clinic;Clinical;Collaborations;commercialization;Communication;Companions;Congestive Heart Failure;COVID-19;Data;Dehydration;design;Development;Device Designs;Devices;diagnostic tool;Dialysis patients;Disease;Durable Medical Equipment;Early identification;Edema;effective therapy;Elderly;Electronic Health Record;Environment;Evaluation;experience;Experimental Animal Model;Fast Healthcare Interoperability Resources;Freezing;global health;Goals;Health Personnel;Healthcare;Heart failure;hemodynamics;Home;Home environment;Hospital Costs;hospital readmission;Hospitalization;Hospitals;Human;Impairment;improved;Incidence;Industry Standard;Laboratories;Lead;Leg;Legal patent;Licensing;Life;life span;Limb structure;Lung;manufacture;Measurement;Measures;Medical;Medicare;meetings;member;Military Personnel;mobile application;Modification;Monitor;Morbidity - disease rate;mortality;non-invasive monitor;novel;older patient;Outpatients;patient population;Patients;pediatric patients;Peripheral;Phase;Physicians;Physiologic Monitoring;Physiological;pressure;prevent;Process;Provider;Pulmonary Capillary Wedge Pressure;Qualifying;Quality of life;Recurrence;remote monitoring;Shortness of Breath;Signal Transduction;Signs and Symptoms;Small Business Innovation Research Grant;Specific qualifier value;Swelling;Symptoms;Technology;telehealth;Telemedicine;Tissues;trend;Triage;usability;validation studies;Venous;virtual;Water;wearable device;Work

PROJECT_TITLE: Non-Invasive Venous Waveform Analysis (NIVA) in patients with Heart Failure (HF)


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: AMHERST

ORG_DEPT: BIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Signaling pathways control specific processes through common or shared factors. How a specific output results from the activation of a common module is a key question addressed by the proposal. Understanding `signaling specificity' is relevant to human health because cross talk between pathways leads to cancer and other diseases.

PI_NAMEs: CULLEN, PAUL JAMES (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Address;Binding;Cancer Etiology;Cell Differentiation process;Cell membrane;Cell Polarity;Cell Shape;cell type;Cells;Disease;experimental study;Family;Glycoproteins;Goals;Growth;GTP Binding;GTP-Binding Proteins;Guanosine Triphosphate;Health;Human;insight;Link;Lysine;Malignant Neoplasms;MAP Kinase Gene;MAPK3 gene;Maps;microbial;Mitogen-Activated Protein Kinases;Modification;Monomeric GTP-Binding Proteins;Mucins;Output;pathogenic fungus;Pathway interactions;Phosphotransferases;Post-Translational Protein Processing;Process;protein degradation;protein function;Protein Kinase;Proteins;Regulation;Reporting;response;rho GTP-Binding Proteins;Role;scaffold;sensor;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Site;Specificity;System;Testing;Ubiquitin;ubiquitin ligase;Virulence;Work;Yeasts

PROJECT_TITLE: Control of MAPK Signaling by Cell Polarity Proteins

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Data Science;Health Services;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Incidentalomas may indicate significant health problems, such as malignancy to the patient in the short or medium term, but also may lead to overtreatment, which comes with substantial downstream expenditures as well as patient anxiety. In this project, we will build natural language processing approaches to extract cancer related incidentalomas reported in radiology reports (Aim 1) and create the first large scale incidentaloma database for half-a-million patients who received radiologic imaging tests in University of Washington Medical Center, Harborview Medical Center, Seattle Cancer Care Alliance, and Northwest Hospital and Medical Center between 2007 and 2019 (Aim 2). This database will be used for clinical and economic analysis of incidentalomas (Aim 3).

PI_NAMEs: GUNN, MARTIN ;YETISGEN, MELIHA  (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Abdomen;Active Learning;Address;Adherence;Adrenal Glands;Age;Agreement;Angiography;Anxiety;cancer care;cancer diagnosis;cancer risk;Caregivers;Categories;Cessation of life;Chest;Clinical;Clinical Data;clinical database;Clinical Practice Guideline;Clinical/Radiologic;Code;cohort;Communication;Communities;comorbidity;cost;Data;data repository;Data Set;Databases;Death Rate;Development;Diagnosis;Disease;Documentation;economic evaluation;economic impact;Economics;Ensure;Epidemic;Expenditure;follow-up;Funding;Future;Growth;Guidelines;Health;health care delivery;health care service organization;health economics;Healthcare;Hospitals;Image;Imaging technology;improved;Incidental Findings;incremental cost;Interdisciplinary Study;Investigation;Kidney;Link;Liver;Lung;Lung nodule;Machine Learning;machine learning method;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Neoplasms;Medical center;Medical Informatics;Methods;Modeling;Modernization;Natural Language Processing;Neck;novel;Oncology;open source;Organ;Outcome;Outcomes Research;overtreatment;Pancreas;Pancreatic Cyst;Patient Noncompliance;patient population;Patient risk;Patients;Performance;Prevalence;Pulmonary Embolism;Radiation exposure;radiological imaging;radiologist;Radiology Specialty;Recommendation;Reporting;repository;Research;Research Project Grants;Risk;Risk Factors;Running;Scanning;Semantics;Services;structured data;surveillance imaging;systematic review;Technology;Testing;Text;Thyroid Gland;Thyroid Nodule;Training;tumor;Universities;Washington

PROJECT_TITLE: Large scale clinical and economic impact analysis of potentially malignant incidental findings in radiology reports

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Adolescent Sexual Activity;Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Opioids;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Sexually Transmitted Infections;Substance Misuse;Substance Misuse Prevention;Tobacco;Underage Drinking

PHR: Project Narrative To stem the epidemics of substance abuse and sexual risk factors related to health disparities among American Indian and Alaska Native (AIAN) youth, this collaborative partnership between a Native school, an AIAN organization, and a university team of Native researchers will focus on the development of sustainable health practices and youth leadership development. Targeting at-risk AIAN youth for primary prevention efforts and enlisting them to become positive youth development health leaders may stimulate important individual and community-wide changes. Better information is needed on cost-effective and culturally-grounded methods to prevent substance use as well as sexual risk reduction results among AIAN youth so that current and future generations of Native communities can thrive and live healthfully.

PI_NAMEs: EVANS-CAMPBELL, TERESA A (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Address;Affect;African American population;Age;Age Years;Alaska Native;Alaska Native population;Alcohol consumption;alcohol prevention;alcohol use initiation;Alcohols;American Indian Population;American Indians;behavior change;Behavioral;Chlamydia;Collaborations;Communities;community based participatory research;cost;cost effective;Data;digital;Disparity;Drug usage;Elderly;Epidemic;Ethnic Origin;Event;Evidence based program;experience;Family;First Intercourses;Future Generations;General Population;Gonorrhea;Health;health disparity;Heart;heroin use;High Prevalence;high school;High School Student;HIV;Indigenous;Individual;Intervention;intervention effect;Lead;Leadership;leadership development;Marijuana;Mediating;Metaphor;Methods;Modeling;Motivation;multidisciplinary;native youth;Opioid;opioid misuse;Oral;Pain;Pathway interactions;Pattern;peer;Pharmaceutical Preparations;Population;Population Programs;positive youth development;Poverty;Predisposition;Prevention;Primary Prevention;Process;programs;Public Health;Quasi-experiment;Race;Randomized;Recording of previous events;Research;Research Infrastructure;Research Personnel;response;Risk;Risk Factors;Safe Sex;Schools;Self Efficacy;sex;sexual and reproductive health;Sexual Health;sexual risk behavior;sexual risk reduction;Sexually Transmitted Diseases;skills;smoking prevalence;social;stem;Stress and Coping;Students;Substance abuse problem;substance use;substance use prevention;Sustainable Development;syndemic;Syphilis;Teenagers;Testing;therapy development;Tobacco;Tobacco use;Training;Tribal School;Tribes;United States;Universities;Unsafe Sex;Waiting Lists;Washington;Youth

PROJECT_TITLE: Discovering Our Story, to develop the Chemawa Journey of Transformation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(55)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Genetics;Precision Medicine;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: RELEVANCE: Breast cancer is the 2nd leading cause of the women’s cancer related death in the United States. Understanding improved means for the treatment of the disease is of clear public health relevance. The overall goal of this project is to advance the understanding of disease recurrence and means to more effectively intercede.

PI_NAMEs: KNUDSEN, ERIK  (contact);WITKIEWICZ, AGNIESZKA

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: 13q;Adjuvant Chemotherapy;Affect;antagonist;Aromatase Inhibitors;Biological;Breast Cancer Model;Breast Cancer Patient;Bypass;CDK2 gene;CDK4 gene;Cell Cycle;Cell Cycle Arrest;Cell Cycle Deregulation;Cell Cycle Progression;Cell Cycle Regulation;Cell model;Cessation of life;Clinic;Clinical;Complex;Critical Pathways;Cytostatics;Data;de novo mutation;Disease;Disease Progression;drug use screening;Estrogen Antagonists;Estrogen receptor positive;Estrogen Receptor Status;Estrogen Receptors;Estrogen Therapy;Estrogens;Event;Evolution;Fulvestrant;Gene Dosage;Gene Expression Profile;Gene Targeting;Genetic;genetic evolution;genetic selection;Goals;Hormonal;hormone therapy;improved;in vivo;inhibitor;Intervention;Malignant Breast Neoplasm;Malignant Neoplasms;Metastatic breast cancer;Modeling;Molecular Target;Neoplasm Metastasis;next generation;Organoids;Pathway interactions;patient derived xenograft model;Patients;personalized approach;Pharmacologic Substance;Pre-Clinical Model;pressure;Process;prognostic;programs;Proliferating;public health relevance;Publishing;receptor function;Recurrent disease;Regimen;Regulatory Pathway;Relapse;Resistance;response;Retinoblastoma Genes;Risk;Sampling;Seminal;Signal Pathway;targeted agent;targeted treatment;Therapeutic;Therapeutic Intervention;therapeutic target;therapy resistant;treatment response;tumor;tumor heterogeneity;Tumor Suppressor Proteins;United States;Woman;Work

PROJECT_TITLE: RB tumor suppressor as a therapeutic target in ER-positive breast cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Liver Cancer;Liver Disease;Lung;Lung Cancer;Nanotechnology;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Therapeutic application of CRISPR/Cas in solid tumors is currently limited by the stiff and fibrotic tumor microenvironment that acts as a barrier to nanoparticle uptake. In this grant application, we propose a unique combination of siRNA-mediated gene silencing of focal adhesion kinase (FAK, a key modulator of tumor extracellular matrix (ECM)) and CRISPR-mediated gene editing (deletion) of programmed death-ligand 1 (PD- L1, a brake that blocks cancer immunotherapy), via an all-in-one Selective ORgan Targeting (SORT) lipid nanoparticle (LNP) approach. Outcomes of this work will include elucidation of the fundamental mechanisms how and why FAK inhibition improves LNP uptake and gene editing, optimized Liver and Lung SORT LNP formulations for multiplexed siRNA + Cas9 mRNA + sgRNA delivery, and therapeutic benefit in orthotopic and genetically engineered mouse models of cancer, ultimately revealing a new strategy to enable CRISPR therapies in solid tumors.

PI_NAMEs: SIEGWART, DANIEL JOHN (contact)

PROJECT_TERMS: Affect;Antibodies;Applications Grants;Biological Markers;Brain;cancer immunotherapy;Cancer Model;cancer therapy;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;Data;design;Encapsulated;Endocytosis;Exhibits;Extracellular Matrix;Focal Adhesion Kinase 1;Formulation;Future;gene correction;gene editing technology;Gene Proteins;gene repair;Gene Silencing;Genes;Genetic Enhancement;Genetic Suppression;Genetically Engineered Mouse;genome editing;Growth;immune cell infiltrate;improved;in vivo;innovation;Intravenous;intravenous administration;Kinetics;knock-down;lipid nanoparticle;Lipids;Liver;liver cancer model;Lung;lung cancer cell;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;Measures;mechanical force;mechanical properties;Mechanics;Mediating;Messenger RNA;Modeling;Modification;mRNA delivery;Mus;Muscle;nanoparticle;nanoparticle delivery;neoplastic cell;Non-Small-Cell Lung Carcinoma;nucleic acid delivery;Nucleic Acids;Organ;Outcome;Pathway interactions;Penetration;Primary carcinoma of the liver cells;programmed cell death ligand 1;Proteins;repaired;Series;Single-Stranded DNA;Small Interfering RNA;Solid Neoplasm;spheroids;Spleen;synergism;System;Therapeutic;therapeutic genome editing;three dimensional cell culture;Tissues;Toxic effect;Treatment Efficacy;Tropism;tumor;Tumor Burden;tumor microenvironment;tumor progression;Tumor Tissue;uptake;Work

PROJECT_TITLE: Multiplexed nanoparticle delivery to increase CRISPR/Cas gene editing for enhanced cancer therapy

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Antimicrobial Resistance;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PUBLIC HEALTH RELEVANCE Men who have sex with men (MSM) are often at an increased risk of gonorrhea and other sexually transmitted diseases. Despite WHO and US CDC recommendations for routine gonorrhea testing, many MSM have never received a gonorrhea test. The proposed community-based pay-it-forward intervention will engage local MSM, generate donations to sustain the testing service, and improve sexual health services for sexual minorities.

PI_NAMEs: TANG, WEIMING ;TUCKER, JOSEPH DAVID (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: Affect;Antibiotic Resistance;Antimicrobial Resistance;arm;authority;azithromycin resistance;Characteristics;China;Cities;Clinic;Clinical Trials;Communities;community engaged approach;community engagement;community partnership;comparison control;cost;Data;Development;Diagnosis;Diagnostic;Diagnostic tests;Early Diagnosis;Effectiveness;effectiveness testing;Equity;evidence base;Feeling;Fees;Financial Hardship;Gifts;Gonorrhea;Government;Health;health service use;Health Services;Healthcare;implementation research;implementation strategy;implementation study;improved;Individual;Infection;Infrastructure;innovation;Intervention;intervention mapping;low and middle-income countries;male health;Measures;men;men who have sex with men;Methods;Mission;Molecular;National Institute of Allergy and Infectious Disease;North Carolina;novel strategies;Observational Study;Participant;Persons;Pharmaceutical Preparations;point of care;point-of-care diagnostics;Population;Preventive service;Price;programs;Province;Public Health;public health relevance;Public Sector;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Research Infrastructure;Resistance;Resource-limited setting;Risk;scale up;screening;service uptake;Sexual Health;sexual minority;sexual minority health;Sexually Transmitted Diseases;Site;Testing;testing services;testing uptake;theories;Time;Translating;Translations;transmission process;treatment arm;Universities;Vaccines;Work;World Health Organization

PROJECT_TITLE: Pay-it-forward gonorrhea testing among men who have sex with men: The PIONEER pragmatic randomized controlled trial

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE: Antibiotic resistance is a looming crisis, with the real possibility of common infections becoming untreatable if we do not increase our ability to combat antibiotic resistant pathogens. This U19 will target the development of antibiotic-sparing therapeutics including rationally designed glycomimetics, peptidomimetics and pyridones, as well as mAbs, that can inhibit key host-pathogen interactions and affect the viability of pathogens that are both antibiotic-sensitive and antibiotic-resistant. Thus, this U19 has great potential to impact human health by combating the rising antibiotic resistance problem.

PI_NAMEs: HULTGREN, SCOTT J. (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: 2-hydroxypyridine;Acinetobacter;Acinetobacter baumannii;Acute;Address;Adhesives;Advanced Development;Affect;Affinity;analog;Animal Model;Antibiotic Resistance;antibiotic resistant infections;Antibiotic Therapy;Antibiotics;Bacteria;Bacterial Adhesins;Bacterial Antibiotic Resistance;Bacterial Infections;Bacterial Proteins;bactericide;Basic Science;Binding;Bladder;Carbapenem-resistant Acinetobacter;carbapenem-resistant Enterobacteriaceae;catheter associated UTI;Cause of Death;Cells;Chemistry;Chronic;Clindamycin;clinical development;Clinical Treatment;Clostridium difficile;Collaborations;combat;combinatorial chemistry;Communicable Diseases;community-acquired UTI;Complex;COVID-19 pandemic;Crystallization;design;Development;Disease;drug discovery;Drug resistance;drug resistant pathogen;Enterobacteriaceae;Enterococcus;Erythromycin;Escherichia coli Adhesins;Escherichia coli drug resistance;Extended-spectrum β-lactamase;extracellular;Family;Fiber;Funding;Generations;glycomimetics;Goals;Gram-Negative Bacteria;Habitats;Health;Healthcare;Human;Immunologist;Immunology;in vivo;Infection;innovation;insight;interdisciplinary approach;Investigational Therapies;Klebsiella;Knowledge;Lead;Life;Ligands;Mannose;Mannosides;Mediating;medical schools;Medicine;meetings;member;Membrane;methicillin resistant Staphylococcus aureus;microbial;Microbiology;mimetics;Molecular;Molecular Chaperones;Monoclonal Antibodies;Multi-Drug Resistance;multi-drug resistant pathogen;Multidrug-resistant Acinetobacter;Multiple Bacterial Drug Resistance;neutralizing monoclonal antibodies;Nosocomial Infections;novel;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Patients;peptidomimetics;Permeability;Pharmaceutical Chemistry;Phase Ia/Ib Clinical Trial;Pilum;pressure;prevent;Process;programs;Pyridones;rational design;receptor;Recurrence;Resistance;resistance mechanism;Resistant Streptococcus pneumoniae;Scientist;small molecule;small molecule inhibitor;small molecule therapeutics;sortase;Streptococcus;Streptococcus Group B;Streptococcus pneumoniae;Streptococcus pyogenes;structural biology;Structure;success;Surface;synergism;Testing;Therapeutic;Therapeutic Monoclonal Antibodies;therapy development;Time;tool;Translating;United States National Institutes of Health;Universities;urgent and serious threat;Urinary tract infection;Uropathogenic E. coli;Usher Proteins;Vaccines;Vancomycin resistant enterococcus;Virulence;Washington;Work

PROJECT_TITLE: Innovative Strategies to Combat Antibiotic-resistant Infections


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: Affinity;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;Area;Attention;Bacteria;Bacterial Adhesins;Bacterial Antibiotic Resistance;Bacterial Infections;Basic Science;Budgets;Cellular biology;Clinical;Collaborations;combat;Combating Antibiotic Resistant Bacteria;Communication;Communication Methods;COVID-19;data exchange;Development;Doctor of Philosophy;Electronic Mail;Ensure;Fostering;functional improvement;Funding;Goals;Grant;Guidelines;Health;Human;Immunology;individual responsibility;Infection;innovation;Institution;Interdisciplinary Study;International;Journals;Leadership;Ligands;Medicine;meetings;member;Membrane;Methodology;Microbiology;mimetics;Monitor;Monoclonal Antibodies;Multi-Drug Resistance;Nosocomial Infections;novel antibiotic class;pathogen;pathogenic bacteria;Pathogenicity;Peer Review;Persons;Pharmaceutical Chemistry;Physiology;prevent;product development;Program Evaluation;programs;Progress Reports;Publications;rational design;Regulation;Research;Research Personnel;Research Project Grants;Resource Sharing;response;Schedule;Scientist;Series;Site Visit;small molecule inhibitor;success;Teleconferences;Therapeutic;therapeutic development;Translating;Translations;United States;United States National Institutes of Health;Wages

PROJECT_TITLE: Administrative Core


ORG_DEPT: CHEMISTRY

PHR: PROJECT NARRATIVE We are interested in understanding at a molecular level how nerve cells conduct electrical signals and how this process is affected by cellular cues, genetic variation, disease, and injury. Chemical synthesis makes possible access to precision reagents that are needed to investigate these complex biological phenomena. Our studies are expected to reveal new insights into the mechanisms through which cells shape neuronal activity and help guide the development of new medicines for treating nervous system disorders.

PI_NAMEs: DU BOIS, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Action Potentials;Acute;Address;Affect;Affinity;Affinity Chromatography;Antibodies;Arrhythmia;Binding;Binding Proteins;bioelectricity;Biological Phenomena;Biotin;Biotinylation;cell fixing;Cell membrane;Cell Shape;cell type;Cells;Cellular Membrane;Chemical Agents;chemical synthesis;Chemicals;Chemistry;Collection;Complex;Cryoelectron Microscopy;Cues;Cysteine;Development;Digit structure;Disease;Drug Kinetics;Electrophysiology (science);Engineering;Epilepsy;Epitopes;experimental study;extracellular;Fluorescent Dyes;Generations;Genetic;genetic approach;Genetic Variation;Goals;guanidinium;Human;human disease;Human Pathology;hydrophilicity;Image;imaging agent;Individual;Inflammation Mediators;Inflammatory;inhibitor;Injury;insight;interest;Investigation;Ions;Kinetics;Label;Lead;Literature;live cell imaging;Lysine;Measures;Medicine;Membrane;Membrane Proteins;Methods;Modeling;Modification;Molecular;Molecular Probes;Movement;Mutagenesis;mutant;Myopathy;nanomolar;Natural Products;Natural Source;Nature;Nerve Block;nerve injury;Nervous System Disorder;Neuroglia;neuronal excitability;Neurons;neurotransmission;Oral cavity;Organism;painful neuropathy;Penetration;Physiology;Population;Post-Translational Protein Processing;Process;programs;Property;protein complex;protein degradation;Protein Isoforms;protein transport;Proteins;Proteomics;Reagent;Reporting;Research;response;Role;Saxitoxin;Shapes;Signal Transduction;Site;Skeletal Muscle;small molecule;Sodium Channel;sodium ion;spatiotemporal;Structure;Study models;success;Surface;Tetrodotoxin;Therapeutic;Tissues;tool;Toxin;Training;Transfection;Vestibule;voltage;Work

PROJECT_TITLE: Guanidinium Toxins as Molecular Probes for NaV Study

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Urologic Diseases

PI_NAMEs: JANETKA, JAMES W (contact)

PROJECT_TERMS: 2-hydroxypyridine;Acinetobacter;Adhesives;analog;antagonist;Anti-Bacterial Agents;Antibiotic Resistance;antibiotic resistant infections;Antibiotic susceptibility;Antibiotics;aqueous;Area;Bacteria;Bacterial Adhesins;Bacterial Antibiotic Resistance;bactericide;Binding;Binding Proteins;Biological Process;Carbohydrates;catheter associated UTI;Chemistry;clinical candidate;Clinical Treatment;Clinical Trials;Collaborations;Collection;combat;Communicable Diseases;COVID-19 pandemic;Cytochrome P450;Dependence;design;Development;Discipline;Docking;Dose;drug discovery;Drug Kinetics;drug resistant pathogen;Enterococcus;Enzymes;Escherichia coli;Evaluation;Feces;Fibrinogen;Galactosides;galacturonic acid;Gastrointestinal tract structure;Generations;global health;glycomimetics;Glycosides;Gram-Negative Bacteria;Grant;Health;healthcare-associated infections;Heterocyclic Compounds;Human;Hydrogen Bonding;improved;in silico;In Vitro;in vivo;Individual;Infection;inhibitor;innovation;interest;Intestines;Klebsiella;Knowledge;Leadership;Lectin;Ligands;Liquid substance;Mannose;Mannosides;Mediating;Membrane;membrane assembly;Metabolic;Methodology;microbial;Molecular Chaperones;Molecular Conformation;molecular modeling;Multi-Drug Resistance;multi-drug resistant pathogen;Mus;Names;novel therapeutics;Organic Chemistry;Organic Synthesis;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Peptides;peptidomimetics;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase Ia/Ib Clinical Trial;physical property;Pilum;Plasma;Plasma Proteins;programs;Property;Proteins;Publishing;Pyridones;rational design;Rattus;Recurrence;Resistance development;scaffold;small molecule;small molecule inhibitor;small molecule therapeutics;Societies;Solubility;structural biology;Structure;success;Surface;System;Testing;Therapeutic;Therapeutic Monoclonal Antibodies;Time;Tissues;Universities;Urinary tract infection;Uropathogen;Uropathogenic E. coli;Validation;Virulence;Washington;Work

PROJECT_TITLE: Rational design and synthesis of small molecule inhibitors targeting unique pathogenic mechanisms in Gram- and Gram+ bacteria important in UTI


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: SAN FRANCISCO

ORG_NAME: SAN FRANCISCO STATE UNIVERSITY

PHR: The San Francisco State University U-RISE program prepares undergraduate students to continue into biomedical PhD degree programs en route to careers in the biomedical research workforce. San Francisco State University has developed into a productive training environment to prepare its students for high quality PhD degree programs. This program will prepare a diverse population of highly talented undergraduate students underrepresented in the sciences to enter into top ranked biomedical PhD degree programs with the skills to successfully complete their PhD degrees.

PI_NAMEs: ESQUERRA, RAYMOND M. (contact);FUSE, MEGUMI M.

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Academic skills;Academic Training;Admission activity;Biomedical Research;career;Communication;community building;Doctor of Philosophy;Educational Curriculum;Educational workshop;Effectiveness;Ensure;experience;Foundations;Funding;Goals;improved;literacy;Measurable;Participant;peer;peer coaching;programs;Qualifying;Research;Research Training;San Francisco;Science;Scientist;Series;skills;skills training;Students;success;Training;Training Programs;undergraduate student;United States National Institutes of Health;Universities;university student;Writing

PROJECT_TITLE: U-RISE at San Francisco State University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: BERKELEY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project narrative Soluble guanylate cyclase (sGC) is an enzyme central to the nitric oxide (NO) signaling pathway in animals. However, a complete structural and mechanistic understanding of the 3-stage activation of sGC by NO has thus far remained elusive. This proposal will harness a newly discovered NO-specific sGC from the colonial single- cell choanoflagellate, Choanoeca flexa, to explore the structural and evolutionary trajectory of sGC regulation using mutagenesis, cryo-electron microscopy, and small-angle X-ray scattering.

PI_NAMEs: THOMAS, WILLIAM CAREY (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Allosteric Regulation;analog;Animals;Binding;Biochemical;Biological Assay;Biophysics;C-terminal;Catalytic Domain;Cells;Cellularity;cofactor;Coiled-Coil Domain;Collaborations;Complex;Cryoelectron Microscopy;Crystallography;Cyclic GMP;design;Development;drug development;Elements;Enzymatic Biochemistry;Enzyme Activation;Enzymes;Equilibrium;Eukaryotic Cell;Evolution;Exhibits;experience;experimental study;Gases;Goals;Guanosine;Heme;heme a;Human;Immune response;improved;Infection;Investigation;Knowledge;Life;Manduca sexta;Mathematics;Mediating;metalloenzyme;Moderate Activity;Molecular Conformation;Monitor;Moths;Mutagenesis;mutant;Mutation;N-terminal;neurotransmission;Nitric Oxide;Nitric Oxide Signaling Pathway;Outcome;Periodicity;Pharmaceutical Preparations;Physiological;Physiological Processes;Physiology;Population Distributions;post-doctoral training;Process;Proteins;Recording of previous events;Regulation;Research;Research Proposals;Resolution;response;Ribonucleotide Reductase;Roentgen Rays;Role;Sampling;Scientist;Secondary to;Signal Pathway;Signal Transduction;Signaling Molecule;Site;skills;small molecule;Soluble Guanylate Cyclase;structural biology;Structure;Surveys;Techniques;therapeutic target;Titrations;Tobacco;tripolyphosphate;Universities;Variant;Vasodilation;Visualization;Work;YC-1

PROJECT_TITLE: Structural and biochemical investigations into the mechanism and evolution of soluble guanylate cyclase regulation


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PHR: Public Health Relevance. Substance use disorders comprise some of the most devastating and expensive to treat disorders in modern society. Determining the neurochemical imbalances underlying such disorders is a key step in developing appropriate therapies; however, in most cases the neurochemistry, especially of extracellular proteins, is not well understood. In this project, we are developing novel instrumentation and techniques that enable proteins to be monitored in the living brain and testing them in an animal model of cocaine use.

PI_NAMEs: KENNEDY, ROBERT T (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: addiction;Adsorption;advanced analytics;Animal Model;Animals;Back;Behavior;Biological Assay;Blood capillaries;Brain;Brain-Derived Neurotrophic Factor;capillary liquid chromatography;Cell Nucleus;cocaine self-administration;cocaine use;Consumption;Coupled;Custom;Data;Detection;Development;Devices;Dialysis procedure;Diameter;Diffusion;Disease;disease model;Dopamine;Drug Addiction;drug of abuse;Effectiveness;extracellular;Extracellular Protein;Extracellular Space;Goals;improved;in vivo;in vivo evaluation;in vivo monitoring;Informatics;insight;instrumentation;interstitial;Liquid substance;Mass Spectrum Analysis;Measurement;Measures;Membrane;meter;Methods;Microdialysis;Modeling;Modernization;Molecular Weight;Monitor;neural;neurochemistry;Neurons;neurotransmitter release;Neurotransmitters;new technology;novel;novel strategies;Nucleus Accumbens;particle;Peptides;Perfusion;Pharmaceutical Preparations;Prefrontal Cortex;Preparation;pressure;Protein Dynamics;Protein Secretion;Proteins;Proteome;Proteomics;public health relevance;Recovery;release factor;Resolution;response;Role;Sampling;Site;small molecule;Societies;Structure;Substance abuse problem;Substance Use Disorder;System;Techniques;Testing;Thick;Time;Tissues;Training;ultra high pressure;Width;Work

PROJECT_TITLE: New Technology for In Vivo Monitoring the Brain Extracellular Proteome at High Spatial Resolution in Substance Abuse Models


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Genetics;Urologic Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Benign prostatic hyperplasia (BPH), a major cause of lower urinary tract symptoms (LUTS), is a highly prevalent debilitating disease in aging men, and its annual treatment costs exceed $4 billion. There is an unmet need for prevention and more effective medical treatment of clinical BPH or LUTS. The proposed mechanistic and preclinical studies will investigate how histological BPH leads to clinical BPH, which will help guide future clinical studies to develop and/or optimize therapeutics targeting mechanisms driving progression from histological BPH to clinical BPH or LUTS.

PI_NAMEs: WANG, ZHOU  (contact);YOSHIMURA, NAOKI

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Affect;afferent nerve;Afferent Pathways;Age;age-related disease;aged;Aging;androgen sensitive;Androgen Suppression;Androgens;Anti-Inflammatory Agents;Automobile Driving;Benign;Benign Prostatic Hypertrophy;Bladder;Cadherins;celecoxib;Cell Line;cell type;Cells;Chronic;Clinical;Clinical Research;Clinical Treatment;clinically significant;cytokine;Data;Disabling;Disease;Down-Regulation;Dutasteride;E-Cadherin;Electrophysiology (science);Epithelial Cells;Epithelium;Etiology;Event;Exhibits;experimental study;Foundations;Functional disorder;Future;Genes;Heterozygote;Histologic;Human;Incontinence;Increased frequency of micturition;Inflammation;Inflammatory;insight;Intercellular Junctions;knockout gene;Knockout Mice;Lower urinary tract;lower urinary tract symptoms;Mediating;Medical;men;micturition urgency;Modeling;Molecular;mouse model;multidisciplinary;Mus;Non-Steroidal Anti-Inflammatory Agents;novel;older men;Overactive Bladder;overexpression;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;preclinical study;Prevention;Proliferating;Prostate;Prostatic;Prostatic Epithelium;Proteins;PTGS2 gene;Quality of life;Rattus;Role;role model;Signal Transduction;Specimen;success;symptom management;Symptoms;Syndrome;Testing;Therapeutic;therapeutic target;therapy development;Tissues;Transfection;Treatment Cost;Urination

PROJECT_TITLE: Role of E-Cadherin Down-Regulation in Prostatic Inflammation and Lower Urinary Tract Dysfunction

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Urologic Diseases

PI_NAMEs: ELLEBEDY, ALI HASSAN (contact)

PROJECT_TERMS: Acinetobacter;Adherence;Adhesives;alternative treatment;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;Bacteria;Bacterial Adhesins;Bacterial Drug Resistance;Binding;Bladder;Bordetella pertussis;Carbapenem-resistant Acinetobacter;carbapenem-resistant Enterobacteriaceae;Catheters;Cells;Centers for Disease Control and Prevention (U.S.);Clinical;Cloning;Collaborations;combat;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Contracts;Development;Drug resistance;drug resistant pathogen;Drug resistant Pseudomonas aeruginosa;Drug-resistant Campylobacter;Drug-resistant Neisseria Gonorrhoeae;Enterobacteriaceae;Enterococcus;Enzymes;Epitopes;Excision;Extended-spectrum β-lactamase;extracellular;Fiber;Fibrinogen;fluid flow;Future;Gastrointestinal tract structure;gene conservation;Generations;Goals;Gram-Negative Bacteria;Health;host colonization;Host Defense Mechanism;Human;human tissue;Indwelling Catheter;Infection;innovation;Interdisciplinary Study;Invaded;Kidney;Klebsiella;Mannose;Mediating;Membrane;Methods;Microbial Biofilms;Molecular Chaperones;Molecular Machines;Monoclonal Antibodies;Monoclonal Antibody Therapy;Mucous Membrane;Multi-Drug Resistance;multi-drug resistant pathogen;multidrug-resistant Pseudomonas aeruginosa;Mutation;Nature;non-typhoidal Salmonella;Operon;pathogen;pathogenic bacteria;Pathway interactions;periplasm;Persons;Pilum;pilus genes;polymerization;Polymers;pressure;prevent;programs;Proteins;Public Health;Pump;Reporting;residence;Resistance;Resistance development;resistance mechanism;resistant Shigella;Salmonella;Serotyping;Site;sortase;success;Surface;System;Techniques;Testing;Therapeutic;therapeutic development;Therapeutic Monoclonal Antibodies;Time;Tissues;tool;Transmembrane Domain;United States;urinary;Uropathogenic E. coli;Usher Proteins;Vaccine Design;Virulence;Work

PROJECT_TITLE: Developing protective monoclonal antibodies against Gram- and Gram+ bacteria


NIH_SPENDING_CATS: Cancer;Genetics

PHR: PROJECT NARRATIVE Many chemotherapies kill cancer cells by inducing genome instability during DNA replication. Emerging evidence suggests that chemotherapy resistance can arise from over-stabilization of replicating DNA due to different mechanisms. This project investigates the molecular mechanism and therapeutic potential of a novel regulator of DNA stability during replication, named profilin-1.

PI_NAMEs: SHAO, JIEYA  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Actin-Binding Protein;Actins;anti-cancer;anticancer activity;arm;Binding;brca gene;Breast Cancer Cell;Camptothecin;cancer cell;Cell Death;Cell Nucleus;Cells;Characteristics;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;Chromatin;Chromosome abnormality;Clinical;cofactor;Complex;coping mechanism;Cytoplasm;Data;DNA;DNA biosynthesis;DNA Damage;DNA lesion;DNA Maintenance;DNA Repair;DNA replication fork;Enzymes;Equilibrium;Excision;Exportins;FANCD2 protein;Foundations;Funding;Genomic Instability;genotoxicity;Grant;Histones;hydroxyurea;Hypersensitivity;insight;Investigation;Knowledge;Malignant Neoplasms;Mammalian Cell;Methylation;micronucleus;Modeling;Molecular;Names;Natural Immunity;novel;Nuclear;nuclease;Nucleosomes;Oncogenes;Outcome;Phenotype;Play;Poly(ADP-ribose) Polymerase Inhibitor;polymerization;Polymers;Predisposition;Process;profilin 1;Proline;Proteins;Publishing;Rationalization;Regulation;Relaxation;replication stress;Reporting;Role;Single-Stranded DNA;Slide;SMARCA5 gene;Solid;Source;stem;Stimulator of Interferon Genes;Stress;Structure;Testing;Therapeutic;Time;Transcription Elongation;treatment response;tumor;tumor growth;Tumor Suppressor Proteins;Up-Regulation;Work

PROJECT_TITLE: Role of nuclear profilin-1 in DNA replication fork stability and cancer chemotherapy response

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: Los Angeles

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Cranial joint defects such as temporomandibular joint disorders are common craniofacial defects, and while vertebrate heads have a diverse number and type of joints, how the location and subtype of joints are specified remains unclear as a result of the limb being the focus of many joint biology studies. My project investigates 1) how cranial joints are specified separately from replacement cartilage of bone and 2) how they are given regional information to specify the joint subtype they eventually become. These findings will lead to a better understanding of the genetic underpinnings of cranial joint diseases, and potentially inform new and improved approaches to prevent or treat craniofacial defects resultant from improper patterning or maintenance of cranial joints.

PI_NAMEs: ELLIOTT, KELSEY  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Adult;Affect;Alleles;Animal Model;arthropathies;Binding;Binding Sites;Bioinformatics;Biological Assay;Biology;bone;California;Cartilage;cartilaginous;cell type;Cells;Cephalic;Chromatin;Classification;Communities;cost;Country;craniofacial;Craniofacial Abnormalities;craniofacial development;craniofacial disorder;Craniosynostosis;cranium;Data;Data Set;Defect;design;Development;Disease;DNA Binding;Dominant-Negative Mutation;Ear;Embryo;Emerging Technologies;Enhancers;Exclusion;experience;experimental study;Face;Fellowship;Fishes;flexibility;Gene Expression;Gene Expression Profiling;Gene Transfer Techniques;Genes;Genetic;genetic testing;Genomics;Goals;Head;Health Sciences;Human;improved;In Situ Hybridization;innovation;Institution;Jaw;joint formation;joint function;Joints;Label;large datasets;Limb structure;Location;Maintenance;Mediating;Mentorship;Modeling;morphogens;mutant;Mutation;Natural regeneration;Neural Crest;Neural Crest Cell;novel;Pattern;Physiologic Ossification;Play;Population;Positioning Attribute;precursor cell;prevent;professor;promoter;Regulatory Element;Replacement Arthroplasty;Research;Resolution;Role;Scientist;single cell analysis;Site;skeletal;Skeletal Development;skeletal tissue;Skeleton;skull base;Specific qualifier value;Surgical sutures;Synovial joint;Techniques;Temporomandibular Joint;Temporomandibular Joint Disorders;tenure track;Testing;transcription factor;Transcription Factor AP-1;transcriptome;transgene expression;Transgenic Organisms;Universities;Vertebral column;Work;Zebrafish

PROJECT_TITLE: Modular Control of Cranial Skeletal Connectivity through Joint-Specific Enhancers

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PI_NAMEs: CLEUREN, AUDREY  (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Acetyl Coenzyme A;Acute;Affect;Blood;Cell Physiology;cell type;Cells;Disease;Endothelial Cells;endothelial dysfunction;Endothelium;Epigenetic Process;Functional disorder;Glycolysis;High-Throughput Nucleotide Sequencing;Histone Acetylation;histone modification;Human;human disease;in vitro Assay;in vivo;Inflammation;Inflammatory;inhibitor;insight;Lead;Location;Mediating;Memory;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;Modification;Molecular;Natural Immunity;Oklahoma;Physiological;Play;Research;Role;Stimulus;Testing;therapeutic target;Tissues;transcriptomics;vascular bed

PROJECT_TITLE: Metabolic and epigenetic reprogramming in the inflamed endothelium


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: Lung cancer is the second-most commonly diagnosed cancer among U.S. Veterans. Significant advances have been made in screening and treatment of lung cancer. Longevity following lung cancer has increased. After lung cancer treatment however, many Veterans experience losses in functional capacity and increased symptoms. Rehabilitation services are needed to address these health issues. This project seeks to better understand Veteran lung cancer survivors’ health goals following treatment, knowledge and outcome expectations for exercise and rehabilitation, and feelings towards technology to guide rehabilitation services. It will also test a telerehabilitation intervention with Veterans after lung cancer treatment, with goals to improve their function and quality of life. This project will advance knowledge on strategies to better meet the rehabilitation needs of Veteran lung cancer survivors. It will also develop the career of a physician researcher to acquire expertise in rehabilitation services for many Veteran lung cancer survivors.

PI_NAMEs: HA, DUC M. (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Adherence;Adverse effects;Adverse event;Aftercare;arm;Authorship;behavior change;Behavioral;behavioral health;Cancer Biology;cancer diagnosis;cancer rehabilitation;Cancer Survivor;Cancer Survivorship;cancer therapy;career;career development;Caring;chemoradiation;Clinical;clinical center;Clinical Research;Clinical Sciences;Clinical Trials;Colorado;Conduct Clinical Trials;cost effective;curative treatments;Data;Data Analyses;design;Diagnosis;Doctor of Philosophy;Education;Elderly;Eligibility Determination;Enrollment;Environment;Equilibrium;Excision;Exercise;exercise capacity;Exercise Physiology;exercise program;exercise rehabilitation;exercise training;expectation;experience;experimental arm;Feeling;functional improvement;Funding;Goals;Health;health goals;Health Sciences;Health Technology;Impaired health;Impairment;Improve Access;improved;innovation;Intervention;Interview;K-Series Research Career Programs;Knowledge;Learning;Leisures;Longevity;loss of function;Lung;Malignant neoplasm of lung;Master of Science;Medical;Medical center;Medical Oncology;Medicine;Mentors;mid-career faculty;Modeling;Non-Small-Cell Lung Carcinoma;oncology program;Operative Surgical Procedures;Outcome;Participant;Patient Outcomes Assessments;Patient Participation;Patient Self-Report;Patients;Physical activity;Physical Function;Physical therapy;Physicians;Postdoctoral Fellow;precision oncology;professor;Program Accessibility;programs;psychosocial;Publishing;pulmonary rehabilitation;Qualitative Research;Quality of life;Radiation;Randomized;randomized trial;Recommendation;Recording of previous events;rehabilitation research;rehabilitation science;rehabilitation service;Rehabilitation therapy;Reporting;Research;research and development;Research Personnel;Safety;screening;Self Efficacy;Services;social cognitive theory;Stage at Diagnosis;Structure;Supportive care;Survival Rate;Survivors;Symptom Burden;Symptoms;System;systematic review;Teacher Professional Development;Techniques;Technology;telehealth;telerehabilitation;Testing;Time;Training;Translational Research;Transportation;Travel;United States Department of Veterans Affairs;Universities;uptake;usability;Veterans;Work

PROJECT_TITLE: Telerehabilitation for Veteran Lung Cancer Survivors Following Curative Intent Therapy

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Urologic Diseases

PROJECT_TERMS: Acinetobacter;Acute;Adhesives;Affinity;antagonist;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;Antibodies;Antibody Therapy;Bacteria;Bacterial Adhesins;Bacterial Antibiotic Resistance;bacterial community;Bacterial Infections;Basic Science;Binding;Biological Availability;Bladder;cancer therapy;candidate identification;carbapenem-resistant Enterobacteriaceae;catheter associated UTI;Catheters;Cell Wall;Cells;Chronic;Chronic Cystitis;Climate;Clinical Treatment;Clinical Trials;Collaborations;combat;Communicable Diseases;community-acquired UTI;COVID-19;design;Development;diabetic;Disease;drug discovery;drug resistant pathogen;Enterobacteriaceae;Enterococcus;Enterococcus faecalis;experimental study;Extended-spectrum β-lactamase;extracellular;Fibrinogen;Funding;Galactose;gastrointestinal;Gastrointestinal tract structure;global health;glycomimetics;Gram-Negative Bacteria;gut colonization;Habitats;Health;Healthcare;host colonization;Human;implant coating;implantation;In Vitro;in vivo;Indwelling Catheter;Infection;Inflammatory;Ingestion;innovation;Invaded;Kidney;Klebsiella;Klebsiella pneumoniae;Knowledge;Life;life span;Ligands;Mannose;Mannosides;Medicine;Microbial Biofilms;mimetics;Modeling;Molecular Chaperones;Monoclonal Antibodies;mouse model;multi-drug resistant pathogen;Multidrug-resistant Acinetobacter;Neurons;Nosocomial Infections;Oral;pathogen;Pathogenicity;Pathway interactions;Pectins;Permeability;Phase;Phase Ia/Ib Clinical Trial;Pilum;Plants;Pre-Clinical Model;pressure;prevent;Privatization;programs;receptor;Recurrence;residence;Resistance;resistance mechanism;Resistance profile;Resources;small molecule;sortase;Structure-Activity Relationship;success;Surface;Testing;Therapeutic;Therapeutic Monoclonal Antibodies;Tissues;Translating;United States;urgent and serious threat;Urinary tract infection;Uropathogen;Uropathogenic E. coli;Vaccines;Vancomycin Resistance;Vancomycin resistant enterococcus;Work;wound

PROJECT_TITLE: Development of anti-adhesin mAbs and high-affinity ligand mimetics to treat and prevent UTIs


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Public health statement The proposed work will study the causes for certain acquired and inherited heart diseases associated with cardiac arrhythmia (=irregular heart beats) and a high risk for sudden and premature deaths. The studies will also examine the benefit of new drugs in animal models and human heart cells generated from patient-derived induced pluripotent stem cells, which will provide important information for new drug therapies for patients with arrhythmia disorders.

PI_NAMEs: KNOLLMANN, BJORN C (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Academia;Accounting;Adult;Animal Model;Anti-Arrhythmia Agents;Area;Arrhythmia;Catecholaminergic Polymorphic Ventricular Tachycardia;Cessation of life;Clinical;cost;Development;Disease;drug development;Drug Industry;Functional disorder;Goals;Heart;heart cell;Heart Diseases;high risk;Human;human induced pluripotent stem cells;Implantable Defibrillators;improved;Inherited;Ion Channel;Knowledge;Membrane;Molecular;mortality;novel strategies;novel therapeutics;Patient Care;patient derived induced pluripotent stem cells;patient subsets;Patients;personalized care;Pharmacotherapy;premature;programs;Public Health;Research;sudden cardiac death;Sudden Death;Syndrome;targeted treatment;Therapeutic;tool;Ventricular Arrhythmia;Vision;Work

PROJECT_TITLE: Toward a Mechanism-Based Approach to Treating Cardiac Arrhythmia


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Human Genome;Regenerative Medicine

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Recent single cell genomic studies of the human intestine have revealed new biological observations about human development, homeostasis and disease; opening the door to uncover novel insights about fundamental human biology. Using single cell genomic approaches, we have identified a new growth factor, Epiregulin (EREG), which is expressed in the stem cells of the developing human intestine, but which is absent from the murine intestine, suggesting a unique role in human development. These studies will shed light onto normal human intestinal homeostasis and may lead to insights into how perturbations to this homeostasis leads to disease.

PI_NAMEs: CHILDS, CHARLIE  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Adult;Animal Model;base;Biochemical;Biological;Biological Assay;capsule;Cell Differentiation process;cell type;Cells;Chromatin;Complex;Conceptions;CRISPR/Cas technology;Cues;Data;Development;Disease;Duodenum;Endothelium;Epidermal Growth Factor;Epiregulin;Epithelium;Event;experimental study;Family member;fetal;Gene Expression Profile;Genes;Genomic approach;Goals;Growth Factor;Heterogeneity;Homeostasis;Human;Human Biology;human data;Human Development;human model;Immune;Immunofluorescence Immunologic;In Vitro;in vivo;induced pluripotent stem cell;inhibitor;insight;intestinal epithelium;intestinal homeostasis;Intestines;Kidney;Lead;Ligands;Light;Location;loss of function;Maintenance;MAP Kinase Gene;Mesenchymal;Mesenchyme;Modeling;Molecular;Morphogenesis;Morphology;multiple omics;Mus;Muscularis Mucosa;Natural regeneration;Neurons;new growth;novel;organoid transplantation;Organoids;Outcome;Pathway interactions;pharmacologic;Phosphorylation;Phosphotransferases;Physiological;Play;Population;Role;Sampling;Secretory Cell;self-renewal;Signal Transduction;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Smooth Muscle;stem cell function;stem cell homeostasis;stem cell niche;stem cells;Stomach;Structure;System;Testing;transcription factor;Transplantation;Villus;Western Blotting;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Investigating the Role of Epiregulin During Human Intestinal Development


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors, which modulate synaptic transmission and serve as drug targets for a variety of neurological disorders. Due to the receptor’s complex multidomain structure and dimerization, the allosteric mechanisms that couple ligand binding to receptor signaling remain poorly understood. Using structural and biophysical approaches, this proposal will elucidate the conformational dynamics and inter-domain interactions that shape the mGluR activation pathway.

PI_NAMEs: STRAUSS, ALEXA  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Affinity;Agonist;Alzheimer's Disease;Anxiety;Architecture;Binding;Biological Assay;biophysical analysis;biophysical techniques;Brain;Brain region;C-terminal;Cells;comparative;Complex;Coupled;Coupling;Cryoelectron Microscopy;Cysteine;Cysteine-Rich Domain;Data;dimer;Dimerization;Disease;Drug Targeting;Exhibits;extracellular;Extracellular Domain;Family;G-Protein-Coupled Receptors;Glutamates;GTP-Binding Proteins;Heterodimerization;Heterogeneity;Homo;improved;In Vitro;insight;Kinetics;Length;Ligand Binding;Ligand Binding Domain;Ligands;Mediating;Mental Depression;Mental disorders;metabotropic glutamate receptor 2;metabotropic glutamate receptor 3;Metabotropic Glutamate Receptors;Modeling;Molecular;Molecular Conformation;Molecular Probes;Mutation;Nervous System;Nervous System Disorder;neurotransmitter release;Neurotransmitters;novel;patch clamp;Pathway interactions;Pattern;pharmacologic;Pharmacology;Physiological;Play;positive allosteric modulator;Property;Publishing;receptor;Receptor Activation;receptor function;Receptor Signaling;recruit;Reporting;Resolution;response;Role;Schizophrenia;Sequence Homology;Series;Shapes;Structure;Synapses;Synaptic Transmission;System;Techniques;tool;Transmembrane Domain;Visualization;Work

PROJECT_TITLE: Structural and Allosteric Mechanisms of mGluR Activation


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Attention deficit/hyperactivity disorder (ADHD) is a prevalent early-onset disorder, reliably identified by preschool age, that impairs acquisition of normative milestones, presages chronic mental health problems, and evidences marked disparities in timeliness and prevalence of identification for minoritized racial and ethnic groups. The proposed research builds from a growing research base on neurodevelopmental risk markers for ADHD at toddler age, focusing particularly on dense measurement of toddler attention (dys)regulation and modeling developmental patterns at individual and group levels, to determine if patterns can be meaningfully characterized during this period of rapid development and whether accounting for change can optimize models of neurodevelopmental vulnerability to ADHD. As their inclusion has important implications for risk assessment and health disparities related to emergent ADHD, this work carefully considers the role of structural and familial risks and protective factors in the pathway toward an impairing disorder of early childhood.

PI_NAMEs: NILI, AMANDA  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: 5 year old;Accounting;Address;adverse childhood events;Age;Age Months;Attention;Attention deficit hyperactivity disorder;Award;base;Behavior;Behavioral;Caregiver well-being;Child;Chronic;Clinical;clinical application;clinical predictors;clinical translation;Collection;Communities;Data;Data Collection;data modeling;Development;diagnostic criteria;Dimensions;Disease;Disparity;early childhood;Early Intervention;early onset disorder;Equation;Equity;Ethnic Origin;Ethnic Population;Goals;Grouping;Growth;health disparity;health inequalities;Impairment;Individual;Inequity;innovation;Intervention Studies;Investigation;Link;Literature;Measurement;Measures;Mental Health;mental set;Mentors;Methods;Modeling;multilevel analysis;novel;Nursery Schools;Outcome;Parents;Pathway interactions;Pattern;Phase;Population;predictive modeling;Prevalence;protective factors;Proxy;Psychopathology;Race;racial diversity;racial minority population;recruit;Regulation;Reporting;Research;Research Personnel;Resources;Risk;Risk Assessment;Risk Factors;Risk Marker;risk prediction model;Role;Sampling;Sampling Studies;School-Age Population;skills;sociodemographics;Specific qualifier value;Standardization;Structural Models;Surveys;Symptoms;Syndrome;Testing;Time;Toddler;tool;Training;Well Child Visits;Work

PROJECT_TITLE: Development matters: Characterizing patterns of emergent ADHD risk through a neurodevelopmental framework

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Prevention;Women's Health Research

ORG_CITY: ROCHESTER

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE  The proposed research aims to expand the capability and performance of ultrasound tomography as a non-ionizing radiation imaging modality that enables greater sensitivity and specificity for breast cancer screening. To achieve this goal, we plan to incorporate both reflection and transmission information in our modeling and inversion approaches to improve and expand the tissue characterization capabilities of ultrasound tomography. Successful completion of this project will improve fundamental understandings of acoustic models and inversion techniques for reflection and transmission ultrasound and further enable quantitative and spatially resolved imaging of tissue properties for the early detection and diagnosis of cancer.

PI_NAMEs: ALI, REHMAN  (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: 3-Dimensional;acoustic imaging;Acoustics;Algorithms;attenuation;bone;Breast;Breast Cancer Detection;Breast Cancer Early Detection;breast cancer metastasis;breast imaging;Callback;cancer biomarkers;Cancer Detection;cancer diagnosis;cost;density;Detection;diagnostic value;Disease;early detection biomarkers;Early Diagnosis;Equation;Exposure to;FDA approved;Goals;Health Care Costs;Healthcare Systems;Image;imaging capabilities;imaging modality;improved;Ionizing radiation;Knowledge;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Ultrasonography;Mammography;Measures;Methods;migration;Modeling;Morphologic artifacts;Nonionizing Radiation;Patient Care;Patients;Performance;Physiologic pulse;Property;Radiation;reconstruction;Research;Resolution;Roentgen Rays;screening;Screening for cancer;Screening procedure;Sensitivity and Specificity;Signal Transduction;sound;Speed;System;Techniques;Technology;Testing;three-dimensional modeling;Tissue Expansion;Tissue imaging;Tissue Model;Tissues;tomography;Translating;transmission process;Ultrasonic wave;Ultrasonography;ultrasound;United States;Water;Woman;Work;World Health Organization;X-Ray Tomography

PROJECT_TITLE: Multiparametric Tissue Characterization for Breast Cancer Screening Using Transmission and Reflection Ultrasound Tomography

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-B(20)L]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Contraception/Reproduction;Emerging Infectious Diseases;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

PHR: PROJECT NARRATIVE: Toxoplasma gondii pathogen of humans and can cross the placental barrier where it represents a significant health threat to the developing fetus. How the placenta resists and responds to pathogen exposure is poorly understood. Our goal is to better understand what happens when T. gondii encounters the placenta with the goal of ultimately developing new ways to predict infection outcomes and specifically if the fetus is at significant risk of infection.

PI_NAMEs: BOYLE, JON P (contact);COYNE, CAROLYN B

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Ablation;Acute;Address;Adhesions;Adopted;Affect;Antiparasitic Agents;base;Biological Assay;Biological Markers;Biology;Blindness;Blood;Bypass;Cell Line;Cell Nucleus;cell type;Cells;Characteristics;chemokine;Clinical;Collaborations;Congenital Abnormality;Congenital Toxoplasmosis;cytokine;Cytokine Signaling;cytotrophoblast;Data;Defense Mechanisms;design;Development;Developmental Delay Disorders;diagnostic tool;enhancing factor;Event;experimental study;fetal;Fetal Development;Fetal health;Fetus;Gene Expression Profile;Genetic Transcription;Goals;Health;Human;human pathogen;Immune;Immune response;Immune signaling;immunoregulation;in utero;in vitro Model;in vivo;Infection;infection risk;Invaded;Knowledge;Lead;Link;Mammalian Cell;Maternal Health;Maternal-Fetal Exchange;Mediating;Modeling;Molecular;Molecular Biology;mouse model;Multivariate Analysis;mutant;neonate;Outcome;Parasites;pathogen;pathogen exposure;Physiological;Placenta;placental infection;placental trophoblasts;Placentation;Predisposition;Pregnancy;Pregnancy loss;Pregnancy Outcome;Pregnant Women;Production;Proteins;Proteoglycan;Publishing;Research Design;Resistance;resistance mechanism;response;Sampling;Series;seroconversion;Serum;Signal Pathway;Signal Transduction;Spontaneous abortion;Sulfate;Surface;Syncytiotrophoblast;Teratogens;Testing;Tissues;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;transcriptome;transmission process;Treatment Protocols;trophoblast;Vertical Transmission;Woman;Work

PROJECT_TITLE: Placental resistance and response to the teratogenic pathogen Toxoplasma gondii

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: YUAN, PENG  (contact)

PROJECT_TERMS: Acinetobacter;Address;Adhesions;Age;alternative treatment;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;Antibodies;appendage;Bacterial Adhesins;Bacterial Drug Resistance;Bacterial Infections;Bacteriology;beta barrel;Binding;Biochemical;Biogenesis;Biological Assay;Biology;Bordetella pertussis;Campylobacter;Carbapenem-resistant Acinetobacter;carbapenem-resistant Enterobacteriaceae;Cell Membrane Permeability;Centers for Disease Control and Prevention (U.S.);Chemicals;combat;Complex;Development;Diagnosis;Drug resistance;drug resistant pathogen;Drug resistant Pseudomonas aeruginosa;Drug-resistant Campylobacter;efficacy testing;Enterobacteriaceae;Escherichia coli;experience;Extended-spectrum β-lactamase;extracellular;Fiber;Fimbriae Proteins;Funding Opportunities;Gram-Negative Bacteria;Habitats;Immunoglobulins;Immunology;In Vitro;in vivo;Individual;Infection;inhibitor;innovation;interdisciplinary approach;International;Invaded;Knowledge;Ligand Binding Domain;Mediating;Membrane;Molecular;Molecular Chaperones;Molecular Conformation;Monoclonal Antibodies;Multi-Drug Resistance;multidisciplinary;multidrug-resistant Pseudomonas aeruginosa;Nature;novel;novel strategies;pathogen;pathogenic bacteria;Pathway interactions;periplasm;Permeability;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pilum;polymicrobial biofilm;Predisposition;prevent;Prevention therapy;programs;Pseudomonas aeruginosa;Public Health;receptor;recruit;Reporting;resistant Shigella;Role;Salmonella;Shapes;Shigella;small molecule;small molecule libraries;structural biology;Structure;Surface;System;targeted treatment;Tertiary Protein Structure;Therapeutic;therapeutic development;Therapeutic Monoclonal Antibodies;therapeutic target;therapy development;Tissues;treatment strategy;United States;urgent and serious threat;Urinary tract infection;Uropathogenic E. coli;Usher Proteins;Virulence;Virulence Factors;Work

PROJECT_TITLE: Antibiotic-sparing strategies targeting outer membrane ushers in Gram-negative bacterial pathogens


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Orphan Drug;Rare Diseases

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

PHR: Narrative: 17 Hsp90 inhibitors that target the N-terminal domain of Hsp90 have undergone clinical evaluation for the treatment of cancer. Unfortunately, most have failed and the remaining IND’s are likely to follow suite due to an identical mechanism of action, which leads to induction of the pro-survival heat shock response and consequently, dose- escalating toxicities. Through a series of key studies, C-terminal inhibitors of Hsp90 have been identified that manifest potent anti-cancer activities and do not induce Hsp90 levels, creating a new opportunity to develop cancer chemotherapeutics that target Hsp90. In this application, the optimization and in vivo evaluation of these compounds against HNSCC will be pursued the hope of delivering a new IND for subsequent clinical evaluation.

PI_NAMEs: BLAGG, BRIAN S J (contact);COHEN, MARK STEVEN

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: 3-Dimensional;Ablation;Academia;Affinity;Aftercare;analog;anti-cancer;anti-tumor drug;anticancer activity;Apoptosis;Apoptotic;Binding;Binding Sites;C-terminal;cancer cell;cancer therapy;Cell Line;Cells;Cetuximab;Cisplatin;Client;Clinic;clinical development;Clinical Trials;Development;Dose;Dose Limiting;Drug Industry;Drug Kinetics;Drug resistance;Drug toxicity;Engineering;Enzymes;Exhibits;Geldanamycin;Genes;Genetic Markers;Growth;Head and Neck Squamous Cell Carcinoma;Heat-Shock Response;Hepatotoxicity;HSP 90 inhibition;Immune;improved;in vivo;in vivo evaluation;inhibitor;innovation;Lead;lead optimization;Ligands;Malignant - descriptor;Malignant Neoplasms;Mediating;meter;Modification;Molecular Chaperones;Molecular Conformation;molecular recognition;N-terminal;nanomolar;neoplastic cell;next generation;Non-Malignant;novel;novel anticancer drug;novel strategies;Novobiocin;Pathway interactions;Patients;Pharmaceutical Preparations;polypeptide;Population;Pre-Clinical Model;pre-IND studies;predictive modeling;prevent;Process;process optimization;Proliferating;protein degradation;protein folding;Proteins;research clinical testing;Research Personnel;Resistance;Schedule;segregation;Seminal;Series;Signal Transduction;Signaling Protein;single-cell RNA sequencing;small molecule;small molecule inhibitor;Solubility;Structure;Therapeutic;therapeutic target;Toxic effect;transcriptome sequencing;tumor;tumor growth;tumorigenic

PROJECT_TITLE: Engineering the Next Generation of Safer Hsp90 Inhibitors

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Precision Medicine

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed research aims to improve somatic variant detection in malformations of cortical development and to better understand the cell-type-specific molecular and functional effects of those variants. This knowledge has the potential to advance the development of precision treatments for drug-resistant epilepsy. Thus, the proposed research is relevant to the NIH’s mission to reduce illness.

PI_NAMEs: BEDROSIAN, TRACY ANN (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Advanced Development;Affect;Astrocytes;Automobile Driving;behavioral outcome;Brain;brain cell;brain tissue;causal variant;Cell Lineage;Cell Nucleus;Cell Separation;cell type;Cells;Child;Clinical;Cognitive;Cortical Malformation;Data;Detection;Development;Diagnosis;Diagnostic;Disease;Excision;exome sequencing;Fluorescence;gene discovery;Gene Expression;Gene Expression Profile;Genetic;Genetic Predisposition to Disease;genetic testing;Genetic Transcription;genetic variant;Genotype;Goals;Hyperplasia;improved;individual patient;innovation;Intractable Epilepsy;Knockout Mice;Knowledge;malformation;malformation in cortical development;member;Mission;Molecular;mosaic;Mosaicism;mouse model;Neurons;novel;novel strategies;Oligodendroglia;Operative Surgical Procedures;Patients;personalized medicine;Phenotype;Precision therapeutics;profiles in patients;Publishing;Recurrence;repository;Research;Resected;Resolution;Seizures;Somatic Mutation;Sorting;targeted treatment;Techniques;Testing;Therapeutic;therapeutically effective;Tissues;transcriptomics;Transgenic Mice;Translating;treatment strategy;United States National Institutes of Health;Variant;variant detection

PROJECT_TITLE: Deciphering brain mosaicism in drug-resistant epilepsy at cellular resolution

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Transient Receptor Potential (TRP) channels are regulated by a broad range of stimuli, including chemicals, temperature and mechanical stress and are directly involved in sensory perception such as taste, olfaction, thermal perception and nociception. TRP channels are implicated in the pathogenesis of numerous diseases and some of them represent important prognostic markers and promising targets for new therapeutic strategies to treat a variety of human cancers. Our goal is to study TRP channels using a combination of biophysical and biochemical techniques and to obtain detailed information about their structure and function that will help to develop new drug design strategies.

PI_NAMEs: SOBOLEVSKY, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Affinity;Algae;Architecture;base;Binding;Biochemical;Biological Assay;Biophysics;Borates;Calcium;Calmodulin;cancer therapy;Cell Line;Cells;chemical synthesis;Chemicals;Cloning;Complex;Cryoelectron Microscopy;Data;Disease;Drug Design;Drug Targeting;Electrophysiology (science);Elements;Epithelium;Eukaryotic Cell;Evolution;experience;Family;Fluorescence;Funding;gain of function;Genetic Polymorphism;genetic variant;Genetic Variation;Goals;Haplotypes;Hearing;High temperature of physical object;Human;human disease;human genome sequencing;hypercalciuria;Image;improved;in silico;Inhibition of Apoptosis;Inhibition of Cell Proliferation;inhibitor;Integral Membrane Protein;Ions;Knowledge;Length;Lipids;Malignant Neoplasms;Mechanical Stress;Mediating;Membrane;Methods;mimetics;Modernization;Molecular;Molecular Conformation;molecular dynamics;Molecular Sieve Chromatography;Mutagenesis;mutant;Mutation;new therapeutic target;Nociception;novel therapeutic intervention;novel therapeutics;overexpression;Pain;Pathogenesis;Pattern;Perception;Permeability;Phosphatidylinositol 4,5-Diphosphate;Physiological;Piperazines;Predisposition;Prognostic Marker;Protein Engineering;Rattus;Regulation;renal calcium;Role;Ruthenium Red;sensor;Sensory;Site;small molecule;Smell Perception;Specificity;Spectrum Analysis;Squirrel;Stimulus;Structure;success;System;Taste Perception;Techniques;Temperature;Therapeutic;Tissues;Touch sensation;TRP channel;TRPV1 gene;uptake;Vanilloid;Variant;Vision;Visualization;voltage;Work;X-Ray Crystallography

PROJECT_TITLE: Structure and function of Transient Receptor Potential Channels

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Mental Health;Pediatric;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: CARSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CALIFORNIA STATE UNIV-DOMINGUEZ HILLS

PHR: PROJECT NARRATIVE High levels of prenatal stress exposure can have long-lasting effects on infants’ abilities to regulate their emotions. Because early problems with emotion regulation increase risk for a wide range of later psychological disorders, identifying factors that protect mothers and their infants from the negative effects of stress during pregnancy is a public health priority. This proposed project, a first step to informing early prenatal prevention of psychological disorders, will provide information about how pregnant women’s day-to-day fluctuations in stressful and positive experiences influence infant outcomes in emotion regulation, particularly among mothers exposed to high levels of chronic stress.

PI_NAMEs: TUNG, IRENE  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Address;Affect;Affective;aged;Aleurites;Award;Behavior;Biosensing Techniques;Birth;Black race;Buffers;Cardiac;career development;Cellular Phone;Childhood;Chronic stress;Data;Data Analytics;Data Collection;Development;Devices;Diagnostic;Diagnostic Factor;Discrimination;emerging adult;emotion regulation;Emotions;Environment;experience;Exposure to;Family;Fetal Development;Generations;girls;Goals;Health;heart rate variability;improved;In Situ;indexing;Individual;Individual Differences;infancy;Infant;infant outcome;Institution;Intervention;Life;Link;Literature;Longitudinal cohort;Longitudinal Studies;Low income;maternal caregiving;maternal stress;Measures;Mental disorders;Mentors;Methodology;Methods;middle childhood;Modeling;Mothers;offspring;Outcome;Parents;Participant;Pathway interactions;perceived stress;Physiological;Physiology;postnatal;Postpartum Period;Pregnancy;pregnant;Pregnant Women;prenatal;Prenatal care;prenatal risk factor;prenatal stress;Prevention;preventive intervention;Process;programs;prospective;protective factors;Protocols documentation;Psychiatry;psychologic;Psychopathology;psychosocial resources;public health priorities;racial minority;racial minority women;Recording of previous events;Recovery;recruit;Recurrence;Regulation;Research;Research Domain Criteria;resilience;resilience factor;Resources;Risk;Risk Factors;Role;Sampling;Self Efficacy;Shapes;Social support;Stress;stress resilience;Stressful Event;stressor;Testing;theories;Training;transmission process;United States National Institutes of Health;Universities;Visit;wearable device;wearable sensor technology;Well in self;Women's cohort;Women's study;Work

PROJECT_TITLE: Maternal Stress Resilience During Pregnancy and Offspring Emotion Regulation

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Urologic Diseases

PI_NAMEs: CAPARON, MICHAEL G. (contact)

PROJECT_TERMS: 2-hydroxypyridine;Address;Antibiotic Resistance;antibiotic resistant infections;Antibiotic Therapy;Antibiotics;Bacillus subtilis;Bacteria;Bacterial Infections;bactericide;Biochemical;catheter associated UTI;Cause of Death;Cell Physiology;Cells;Cessation of life;chemical genetics;Chemicals;Clindamycin;Clinical;Clostridium difficile;Collaborations;combat;Data;density;Development;Dose;Drug Design;Drug resistance;drug resistant microorganism;druggable target;efficacy evaluation;Environment;Erythromycin;Essential Genes;Evaluation;experimental study;Expression Library;Family;Fibrinogen;fitness;Genes;Genetic;genetic approach;genetic resource;global health emergency;Goals;Gram-Positive Bacteria;Healthcare;Hospitals;Human;improved;In Vitro;in vitro Model;in vivo;in vivo evaluation;Infection;Infectious Skin Diseases;innovation;Lead;methicillin resistant Staphylococcus aureus;Methodology;Microbe;Microbial Biofilms;Microbiology;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;mouse model;Multi-Drug Resistance;multi-drug resistant pathogen;Mus;next generation;Nosocomial Infections;novel;Organic Chemistry;Organism;overexpression;pathogen;Pathogenesis;Pathogenicity;Patients;polymicrobial biofilm;Positioning Attribute;Prevalence;Process;Property;Recording of previous events;Resistance;Resistant Streptococcus pneumoniae;Respiratory Tract Infections;scaffold;Skin;soft tissue;Soft Tissue Infections;Solubility;standard of care;Streptococcus Group B;Streptococcus pyogenes;Structure;Structure-Activity Relationship;synergism;System;Talents;Testing;therapeutic development;therapeutic target;Tissues;Toxic effect;Translations;Urinary tract;Urinary tract infection;Urine;Vancomycin resistant enterococcus

PROJECT_TITLE: GmPcides: Componds that disarm antibiotic resistance in multiple gram-positive pathogens