NIH_SPENDING_CATS: Aging;Genetics;Human Genome

ORG_DEPT: BIOLOGY

ORG_NAME: BROWN UNIVERSITY

PHR: Narrative Metformin has the potential to increase lifespan in several animal model systems. It is currently explored for its potential to slow human aging. Yet, the underlying mechanism by which metformin increases, or in some cases decreases lifespan are unresolved. We propose to conduct a genome wide association study with Drosophila to uncover how metformin modulates aging.

PI_NAMEs: TATAR, MARC  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Acceleration;Adult;Affect;age related;Aging;analytical method;Animal Model;Bioinformatics;Biological Models;Candidate Disease Gene;cohort;Complex;Complex Genetic Trait;Data;Data Analyses;Diet;Dissection;Dose;Drosophila genome;Drosophila genus;experience;Experimental Genetics;extend lifespan;Failure;fly;Gene Expression;Gene Order;Genes;Genetic;Genetic Epistasis;Genetic study;Genetic Variation;genome wide association study;Genomics;hazard;Human;innovation;knock-down;life span;Longevity;Mammals;Maps;Meta-Analysis;Metformin;Methods;Molecular;mortality;Mus;novel strategies;Orthologous Gene;Pathway interactions;Positioning Attribute;reference genome;Regulation;response;RNA Interference;segregation;semiparametric;Series;sex variable;Site;success;Survival Analysis;Testing;trait;Translating;validation studies;Variant;Work

PROJECT_TITLE: Genome wide association analysis with Drosophila to discover how metformin effects longevity


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative The mission of the Harvard/MIT MD-PhD Program is to “train the next-generation of premier and diverse physician- scientist leaders” who embody the dual-calling to make a difference today by touching the life of a patient in need and make a difference tomorrow by achieving scientific breakthroughs that will change our world. By harnessing the educational, clinical, and scientific resources of Harvard Medical School, Harvard University, the Massachusetts Institute of Technology, and its world-class hospitals and affiliated institutes, we aim to provide our students with unparalleled depth and breadth of clinical and research opportunities supported by a profoundly caring and invested community of student colleagues, faculty mentors, and program staff. Our dynamic training program is based on a series of academic and integrative objectives, girded by principles of rigor, integrity, responsibility, self-evaluation, inclusivity, diversity, and empathy, with the ultimate goal of contributing to a much-needed, multidisciplinary MD-PhD workforce to serve the critical health care and biomedical technology needs of the United States and beyond.

PI_NAMEs: JONES, DAVID SHUMWAY;LEES, JACQUELINE A.;REID, ANDREA E;WALENSKY, LOREN DAVID (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PISCATAWAY

ORG_DEPT: GENETICS

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Serrated tumors are a subset of colon tumors with especially poor prognosis, and while these tumors are believed to initiate with mutations to the BRAF gene, the immediate consequences of these mutations within cancer-initiating cells remain unclear. Using new technologies, the proposed research will investigate changes in gene regulatory mechanisms in the moments after oncogenic mutations in BRAF. The proposed studies are significant in that they will facilitate chemoprevention, early detection, and/or tumor-suppression strategies for Serrated colon cancer.

PI_NAMEs: VERZI, MICHAEL P. (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Address;Adenocarcinoma;ATAC-seq;Benign;Binding;Biopsy;BRAF gene;cancer initiation;cancer subtypes;CDX2 gene;Cell Differentiation Induction;Cell Nucleus;Cells;Chemoprevention;Chromatin;Colon;Colon Carcinoma;Colonic Neoplasms;Colorectal Cancer;Data;Differentiated Gene;Early Diagnosis;EGF gene;Environment;epigenomics;Epithelial Cells;epithelial injury;Epithelium;Event;fetal;gain of function mutation;Genes;Genetic;Genetic Models;Genetic Transcription;Genome;genomic locus;Goals;Grant;Growth;Hour;Human;in vivo;in vivo Model;Inflammatory;Injury;injury and repair;innovation;intestinal epithelium;Intestines;Knowledge;KRAS2 gene;MADH4 gene;MAP Kinase Gene;MAPK1 gene;MAPK3 gene;Maps;Measurement;Measures;Modeling;Molecular;Monitor;mouse model;Mus;mutant;Mutate;Mutation;Natural regeneration;new technology;Nuclear;Oncogenic;Pathway interactions;Patients;permissiveness;Phosphorylation;Pre-Clinical Model;Predisposition;preservation;prevent;Prevention strategy;Prognosis;programs;Proteins;Publishing;recruit;regenerative;Research;response;restoration;Screening for cancer;Signal Transduction;stem cell differentiation;stem cell division;stem cells;Testing;Therapeutic;therapeutic evaluation;tissue repair;Tissues;tool;transcription factor;transcription factor CDX2;transcriptome;transcriptome sequencing;Transgenic Model;tumor;tumor initiation;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis;Work

PROJECT_TITLE: Mechanisms of Serrated Colon Tumor Suppression

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hematology;Liver Cancer;Liver Disease;Orphan Drug;Prevention;Rare Diseases;Regenerative Medicine

ORG_CITY: EAST LANSING

ORG_DEPT: PATHOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Some patients who have unhealthy tissue (e.g., a tumor) removed from their liver using a surgical procedure called partial hepatectomy develop complications because the remaining liver tissue does not sufficiently regenerate to recover its normal function. Our studies suggest that partial hepatectomy is associated with activation of blood clotting in the liver of humans and mice, and that a specific blood clotting protein, fibrinogen, can promote liver regeneration. The primary goal of this research is to discover how fibrinogen promotes liver regeneration so that we can discover new strategies to predict, prevent and ultimately treat liver dysfunction in patients after partial hepatectomy.

PI_NAMEs: LUYENDYK, JAMES P (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Afibrinogenemia;Biochemistry;biomarker development;Blood coagulation;Blood Coagulation Factor;Blood Platelets;Cessation of life;Clinical;Clinical Research;Coagulation Process;Complication;crosslink;Deposition;Development;Ensure;Excision;experimental study;Factor XIII;Failure;FDA approved;Fibrin;Fibrinogen;Functional disorder;Gene Modified;genetic approach;Glutaminase;Goals;Hemostatic function;Hepatectomy;Hepatic;Hour;Human;improved;innovation;Integrin Inhibition;Integrins;International;intrahepatic;Link;Liver;liver biopsy;Liver diseases;Liver Dysfunction;Liver Failure;liver function;liver injury;Liver neoplasms;Liver Regeneration;Malignant neoplasm of liver;Measures;Metastatic Neoplasm to the Liver;Modification;Mus;mutant;Mutation;Natural regeneration;new therapeutic target;novel;novel strategies;Operative Surgical Procedures;Outcome;outcome prediction;Partial Hepatectomy;Pathology;Patient Care;Patients;pharmacologic;Physicians;Plasma;Platelet aggregation;platelet function;Polymers;predictive marker;prevent;Procedures;Proteins;Publishing;Recovery;Regenerative pathway;Regenerative response;regenerative therapy;repository;Research;Research Personnel;Role;Sampling;Scientist;Secondary to;Structure;Supplementation;targeted treatment;Testing;Therapeutic;therapeutic target;Time;Tissues;Translational Research;tumor;Wild Type Mouse

PROJECT_TITLE: Novel coagulation-dependent mechanisms of liver regeneration to detect and prevent liver dysfunction after partial hepatectomy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-J(06)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Rare Diseases;Spina Bifida

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Dysregulation of the actin and myosin network can profoundly disrupt how cells respond to their environment and communicate with one another, leading to cancer and birth defects, such as neural tube defects and hereditary deafness. The proposed work will advance our understanding of how actin and myosin networks influence cell-cell communications essential for tissue assembly. Ultimately, this new knowledge will facilitate diagnosis and treatment of human birth defects and help improve the health and quality of life by restoring, maintaining, or enhancing tissue and organ function.

PI_NAMEs: LU, XIAOWEI  (contact);SUTHERLAND, ANN E

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Actins;Actomyosin;Alleles;AMOT gene;Antibodies;Apical;Behavior;Binding;Biochemical;Biochemistry;Biological;Biological Assay;Biomechanics;cell behavior;Cell Communication;cell motility;Cell Polarity;Cell Shape;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Complex;Congenital Abnormality;constriction;convergent extension;Couples;Cytokinesis;Cytoskeleton;Data;deafness;Defect;design;Development;Diagnosis;directional cell;Disease;E-Cadherin;Embryo;Environment;Epithelial Cells;Etiology;experimental study;fluorescence imaging;Fluorescence Resonance Energy Transfer;Foundations;Generations;Genes;Genetic;genetic deafness;Goals;Health;heart defect;Human;improved;in silico;In Situ;in vivo;Inner Hair Cells;insight;Integrins;Intercalated Cell;interdisciplinary approach;Knock-in;Knock-in Mouse;Knowledge;Labyrinth;Ligands;live cell imaging;Malignant Neoplasms;Maps;mechanical force;Mechanics;mechanotransduction;Mediating;Medical;Microfilaments;Molecular;Molecular Conformation;Morphogenesis;Motor;mouse genetics;mouse model;Movement;Mus;mutant;Mutant Strains Mice;Mutation;Myosin ATPase;Myosin Type II;neural;neural correlate;neural plate;Neural tube;Neural Tube Closure;Neural Tube Defects;Neurofibromin 2;neuroimaging;novel;Organ;Pathogenicity;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphotransferases;Physiology;planar cell polarity;Play;polarized cell;Process;protease-activated receptor 3;Protein Tyrosine Kinase;Proteins;Quality of life;receptor;Regulation;rho GTP-Binding Proteins;Role;Scaffolding Protein;sensor;Sensory Hair;Series;Signal Pathway;Signal Transduction;src-Family Kinases;Surface;Testing;Time;Tissues;transcription factor;Tube;Variant;Work

PROJECT_TITLE: Mechanisms of mechanotransduction during neural tube morphogenesis

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: FLAGSTAFF

ORG_DEPT: MISCELLANEOUS

ORG_NAME: NORTHERN ARIZONA UNIVERSITY

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The Southwest Health Equity Research Collaborative (SHERC) will recruit and support a new cadre of health equity-related researchers to grow basic biomedical, clinical, and behavioral research at Northern Arizona University with a focus on translational research, team science and diversity, equity, inclusion, and justice. SHERC research projects will explore multi-level factors that might lead to increased health risks and disease transmission, and variables that may affect disease morbidity and mortality in underserved populations in Arizona and the southwestern United States. In collaboration with community-based organizations, community leaders, policy experts, and researchers, SHERC will identify relevant strategies to enhance community assets and resilience to minimize the impacts of health disparities and advance health equity in our region.

PI_NAMEs: BALDWIN, JULIE ANN (contact)

PROGRAM_OFFICER_NAME: JOSEPH, SUSAN KALAPURA

PROJECT_TERMS: 2019-nCoV;Accountability;Address;Affect;airway inflammation;Area;Arizona;Asthma;authority;Basic Science;Behavior Therapy;behavioral health;Behavioral Research;Behavioral Sciences;Biomedical Research;Biometry;career;Childhood Asthma;Chronic Disease;Clinical;Clinical and Translational Science Awards;Clinical Research;Clinical Sciences;Collaborations;Communicable Diseases;Communities;community collaboration;community engagement;community organizations;community partners;Computing Methodologies;coping;County;Data Analyses;Data Collection;data quality;Data Science;Data Security;design;Development;Disease;disease transmission;efficacious intervention;empowerment;Ensure;Environment;epidemiological model;equity, diversity, and inclusion;Evaluation;evidence base;Extramural Activities;Federally Qualified Health Center;Feedback;Fiber;Fostering;Funding;Geography;Goals;gut microbiome;Health;health disparity;health disparity populations;health equity;Health equity research;health goals;health inequalities;Hospitals;Imprisonment;improved;Individual;Informatics;Infrastructure;innovation;Institution;inter-institutional;Intervention;Justice;Laboratories;laboratory equipment;leadership development;member;Mentors;Methodology;Methods;minority communities;Minority Groups;minority health disparity;Minority Health Research;Minority-Serving Institution;Modeling;Morbidity - disease rate;mortality;novel;Physical activity;Pilot Projects;Policies;Population;Population Heterogeneity;Postdoctoral Fellow;Productivity;Program Development;programs;Quality Control;recruit;Reduce health disparities;reduce symptoms;Relationship-Building;Research;Research Design;research facility;Research Personnel;Research Project Grants;resilience;respiratory microbiome;Risk;Role;Schools;Science;Scientific Inquiry;sedentary lifestyle;senior faculty;social health determinants;Southwestern United States;spatial epidemiology;Supplementation;Testing;theories;Time;tool;Translational Research;tribal health;tribal organization;Tribes;Underserved Population;United States Indian Health Service;United States National Institutes of Health;Universities;women's outcomes;Work


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative: The proposed research is relevant to public health because it seeks to inform upon the potential benefits of surgical versus medical intervention for type B aortic dissection through the development of modern geometric and mechanistically based selection criteria. Upon completion there will be a richer and more nuanced understanding of aortic stability as defined from computed tomography angiography imaging, which will allow for more optimal patient selection. Thus, the proposed research is relevant to the part of the NIH’s mission to enhance cardiovascular health and improve mortality.

PI_NAMEs: POCIVAVSEK, LUKA  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Algorithmic Analysis;Algorithms;Angiography;Aorta;Behavior;biomechanical model;Biomechanics;blood pressure variability;cardiovascular health;Cessation of life;Characteristics;Classification;Clinical;Clinical Management;Clinical Pathways;clinically relevant;Computer Models;Computer Vision Systems;Data;Data Set;Development;Diameter;differential geometry;dimension reduction;Dimensions;Disease;Dissection;Elasticity;Elements;Equilibrium;Evaluation;Evolution;Failure;Foundations;geometric structure;Geometry;Goals;Growth;high risk;Image;improved;indexing;individual patient;Injury;innovation;Intervention;Link;Maps;Measures;Mechanics;Medical;Methods;Mission;Modeling;Modernization;mortality;novel;Operating Rooms;Operative Surgical Procedures;Outcome;Pathway interactions;Patient imaging;patient population;Patient Selection;patient variability;Patients;Pattern;Physiological;preservation;Principal Component Analysis;Probability;Process;Public Health;Research;Risk;risk stratification;Role;Scanning;Selection Criteria;Shapes;simulation;Stress;success;Surgeon;surgical risk;System;Techniques;Testing;Time;tool;United States National Institutes of Health;Validation;Walking;Work;X-Ray Computed Tomography

PROJECT_TITLE: A Geometric and Morphoelastic Study of Aortic Dissection Evolution

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Address;Advisory Committees;American Indians;Area;Arizona;Behavioral Research;Benchmarking;Biomedical Research;Budgets;cancer prevention;career;Clinical Research;Collaborations;Communities;community partners;Creativeness;Data;Decision Making;design;Development;Ensure;Evaluation;experience;Feedback;Funding;Goals;Government;health disparity;health disparity populations;health equity;Health equity research;Hispanic;Human Resources;improved;Individual;Infrastructure;innovation;Institution;institutional capacity;Latinx;Leadership;Logic;meetings;microbiome;Minority-Serving Institution;model design;Monitor;Native American Research Center for Health;Native Americans;Outcome;Output;pathogen;programs;Recommendation;Reporting;Research;research and development;Research Personnel;Research Project Grants;Resources;Schedule;Science;Southwestern United States;Strategic Planning;success;System;Targeted Research;Time;training opportunity;translational approach;Universities;Vision

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: CAMPLAIN, RICKY L. (contact)

PROJECT_TERMS: Administrator;Alaska Native;American;American Indians;Anxiety;anxiety symptoms;Arizona;Blood Pressure;Body Composition;cardiovascular risk factor;Chronic;Cohort Studies;Collection;County;Data;Dedications;design;detention center;Deterioration;diaries;Disease;Disparity;Drug Addiction;Epidemic;exercise intervention;experience;Food Services;Gender;gender difference;gender disparity;General Population;Goals;Growth;Health;health equity;Health equity research;Housing;Hypertension;Imprisonment;Improve Access;improved;improvement on sleep;Individual;Inequality;Institution;Intervention;Interview;Jail;Leisures;Maintenance;Manuals;Measures;Medical;men;Mental Depression;Mental disorders;Mental Health;Modeling;moderate-to-vigorous physical activity;Modification;novel;Outcome;outcome disparities;Pattern;Physical activity;physical conditioning;physical inactivity;Policies;poor health outcome;poor sleep;Probability;Procedures;Prospective cohort;Recommendation;Records;Recreation;Reporting;Research;Risk;Running;Rural;Schedule;sedentary;sedentary lifestyle;Sex Bias;sex variable;sleep quality;social;Stress;Structure;success;Time;time use;Weight Gain;Woman;women versus men;Women's Health;Work;Yavapai

PROJECT_TITLE: Gender Differences in Physical Activity Opportunities and Impacts While Incarcerated


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE: Tissue-engineered medical products (TEMPs) have the potential to restore form, function and appearance to patients who suffer from trauma, disease or congenital defects that are otherwise untreatable by either pharmaceuticals or biopharmaceuticals. TEMPs can also be used in research and development for drug screening, for personalized medicine, and could reduce the need for animal testing. The fact that these products are not available commercially highlights a large and pressing unmet demand; the goal of this project is to develop technological solutions to transition tissue engineering from laboratory-scale to the world of commercial manufacturing.

PI_NAMEs: WELTER, JEAN F (contact)

PROGRAM_OFFICER_NAME: RUSSELL, LUISA MARIE

PROJECT_TERMS: Adoption;Animal Testing;Appearance;Automation;Basic Science;Biological;Biological Products;Biomedical Engineering;biomedical imaging;Bioreactors;Biosensing Techniques;bridge program;Cartilage;Cell Culture Techniques;Cell Physiology;Cells;Cessation of life;Characteristics;Clinical;Collaborations;Communities;Community Developments;Conditioned Culture Media;Congenital Abnormality;cost effective;Data Management Resources;design;Development;Disease;Drug Screening;Education;Engineering;Ensure;Evaluation;Evolution;experience;fabrication;Feedback;Feeds;flexibility;Funding;Generations;Goals;Growth;improved;Individual;innovation;innovative technologies;insight;Institute of Medicine (U.S.);Intervention;Knowledge;Laboratories;manufacture;manufacturing process;manufacturing systems;manufacturing technology;Mechanical Stimulation;Medical;meetings;Methods;Modeling;Molecular;Monitor;multimodality;Names;new technology;non-invasive monitor;novel;optical sensor;Pathway interactions;Patients;personalized medicine;Pharmacologic Substance;Phenotype;prevent;Process;product development;program dissemination;programs;Property;Protocols documentation;prototype;Publications;Quality Control;regenerative;Regenerative Medicine;Reporter;Reproducibility;research and development;Resources;Running;scaffold;Science;sensor;Services;Shapes;Site-Directed Mutagenesis;success;symposium;synergism;Technology;Testing;Time;Tissue constructs;Tissue Engineering;Tissues;tool;Training;Trauma;user-friendly;Vertebral column;web site

PROJECT_TITLE: Center for Modular Manufacturing of Structural Tissues


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: The proposed public health focused research will elucidate the links between specific neighborhood and societal indicators of structural racism and subsequent mental health, as well as stress-related neurophysiological mechanisms and sociocultural buffers that account for and influence this link. Identifying these mechanisms and buffers will inform advances in targeting, not only intermediate proximal pathways, but also fundamental causes of poor mental health that contribute to mental health disparities and inequities.

PI_NAMEs: HYDE, LUKE WILLIAMSON (contact);MITCHELL, COLTER M.S.;MONK, CHRISTOPHER STEPHEN;NEBLETT, ENRIQUE W

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Age;Birth;Black American;Buffers;caucasian American;Censuses;Child;Child Rearing;Child Welfare;Chronic;Cities;cohort;Communities;community-level factor;Criminal Justice;critical developmental period;Data;Data Collection;Development;Dimensions;Discrimination;Disease;Elements;emerging adult;evidence base;Exclusion;experience;Exposure to;Family;Foundations;Geography;Goals;Health;health disparity;health equity promotion;health inequalities;Health Promotion;Immune;Individual;Institution;Intervention;Life Cycle Stages;Link;Longitudinal Studies;Low income;Measurement;Measures;Mental Health;Neighborhoods;neurophysiology;Neurosciences;Outcome;Participant;Pathway interactions;Personal Satisfaction;physical conditioning;Physiological;Policies;Positioning Attribute;Poverty;Process;promote resilience;Psychology;Public Health;Race;racial health disparity;racial identity;racism;Recording of previous events;Reduce health disparities;Religion;Research;residential segregation;resilience;resilience factor;Resources;response;Risk;Role;Sampling;Schools;segregation;social cohesion;social culture;Socialization;sociocultural determinant;Sociology;Stress;Structural Racism;Structure;System;Testing;Therapeutic Intervention;transition to adulthood;Variant;Violence;Vulnerable Populations;young adult

PROJECT_TITLE: Structural Racism and Black American Mental Health: Neurophysiological Mechanisms and Sociocultural Processes Promoting Resilience During the Transition to Adulthood


NIH_SPENDING_CATS: Biotechnology;Data Science

PROJECT_TERMS: Access to Information;Address;Advisory Committees;Agreement;Authorization documentation;Award;Committee Members;Communication;Communities;Complex;Computer software;conflict resolution;Contracts;cost;Data;data repository;Data Science;data science management;Databases;Disclosure;empowerment;Ensure;Equilibrium;Equipment;Funding;Funding Agency;Goals;Grant;Human Resources;human subject;IACUC;Industry;innovation;Institutional Review Boards;Internet;invention;Leadership;Legal;Legal patent;manufacture;Marketing;material transfer agreement;Medical;meetings;Mission;Monitor;National Institute of Biomedical Imaging and Bioengineering;Notification;operation;Outcome;outreach;Participant;Persons;Procedures;Process;Productivity;Publishing;Recommendation;recruit;Regulation;Reporting;repository;Research;research and development;Resources;Retirement;Running;Schedule;Science;Scientist;Services;skills;social media;statistics;symposium;Technology;Technology Transfer;Thinness;Tissue Engineering;Tissues;Training;training project;Translations;Travel;United States National Institutes of Health;Universities;Update;Vision;web site;Work


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Microbiome;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: COPE, EMILY K (contact)

PROJECT_TERMS: Accident and Emergency department;Acetates;Address;Adherence;Affect;airway inflammation;allergic airway inflammation;Area;Arizona;Asthma;asthma exacerbation;asthmatic;asthmatic patient;Black race;Blood;Butyrates;Carbohydrates;cell type;Cells;Child;Childhood Asthma;Chronic;Clinic;Clinical Trials;cohort;Colon;community partnership;Complex;Consumption;coping;County;Dendritic Cells;Development;Diagnosis;Diet;dietary;Dietary Fiber;Dietary Intervention;Dietary Practices;Disease;Disparity;Ecology;Economic Burden;economic disparity;Economics;Environmental Exposure;Enzymes;eosinophil;Evaluation;experience;Family;Fermentation;Fiber;Funding;genetic risk factor;Goals;gut microbiome;gut microbiota;Health;health disparity;health equity;Health equity research;healthcare burden;Hispanic;Homing;host microbiota;host-associated microbial communities;host-microbe interactions;Human;Hypersensitivity;Immune;Immune system;improved;In Vitro;in vivo;Incidence;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Intake;Intervention;Link;Low Income Population;low socioeconomic status;Lung;Measures;Mediating;Metabolic;Metabolism;metropolitan;microbial;microbial composition;microbiome;microbiome composition;microbiota;microbiota metabolites;migration;minority children;Morbidity - disease rate;Mus;nasal microbiota;Not Hispanic or Latino;Nutritional;Obesity;Outcome;patient population;Patients;Pediatric Hospitals;Peripheral;Persons;Phenotype;Physiological;Pilot Projects;Play;polarized cell;Population;Poverty;preclinical study;Prevalence;Preventive;Process;Production;Propionates;Protocols documentation;Public Health;Recommendation;recruit;reduce symptoms;Reducing diet;Reporting;respiratory microbiome;Risk;Risk Factors;Role;Scientist;Site;skills;Small Intestines;soluble fiber;Supplementation;T-Lymphocyte;Travel;underserved community;Underserved Population;urban area;Urban Population;urban residence;urban underserved;Visit;Volatile Fatty Acids

PROJECT_TITLE: Evaluation of Soluble Fiber as a Strategy to Decrease Asthma Morbidity in Underserved Populations


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Wound Healing and Care

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Wound healing is an energetically demanding process and outcomes of identical wounds in different individuals are notably heterogeneous, ranging from regenerative (low scarring) in some to functionally debilitating and harmful scarring (high scar) in others, which often causes major healthcare, psychosocial, and economic burdens. To address this vital unmet clinical need, our aim is to discover what determines human wound healing and scar heterogeneity so that we can create therapies to reduce or even prevent fibrosis and scars in both dermal and other organ injuries. The research proposed in this application will investigate how cells from different patients uniquely change their energy metabolism in response to biomechanical tension and oxidative stress after injury to result in different degrees of scarring, which could inform the development of effective new therapies to improve tissue repair.

PI_NAMEs: BALAJI, SWATHI  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Actins;Address;aerobic glycolysis;antifibrotic treatment;biobank;Bioenergetics;Biological Models;Biomechanics;career;Cell Proliferation;Cells;Cicatrix;Clinical;clinically relevant;Collagen;Communication;Cytoskeleton;Data;Deposition;Dermal;design;Development;dimer;Dimerization;Disease;Economic Burden;Energy Metabolism;Enzymes;experimental study;Extracellular Matrix;Fibroblasts;Fibrosis;Foundations;gain of function;Glycolysis;healing;Healthcare;Heterogeneity;Human;improved;In Vitro;in vivo;Individual;Inflammatory;Injury;Invaded;Knowledge;Lead;Link;loss of function;Malignant Neoplasms;mechanical signal;Mechanics;mechanotransduction;Mediating;Mediator;Metabolic;Metabolic Pathway;metabolic profile;Metabolism;migration;Mitochondria;Molecular Chaperones;Morbidity - disease rate;Mus;Natural regeneration;novel;novel therapeutics;Organ;organ injury;Outcome;Oxidative Phosphorylation;Oxidative Stress;Oxygen;p38 Mitogen Activated Protein Kinase;Pathway interactions;Patients;Phenotype;Phosphorylation;Phosphotransferases;Physiological;predictive modeling;Predisposition;prevent;Process;Production;Proliferating;Proteome;psychosocial;regenerative;Regulation;Research;response;response to injury;Role;Scleroderma;Signal Transduction;Skin;skin healing;Skin injury;Source;stem;Testing;Therapeutic;tissue repair;transcriptomics;Transforming Growth Factor beta;Transplantation;Validation;Variant;Warburg Effect;whole genome;wound;wound healing;Wound models;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Differential changes in energy metabolism in response to mechanical tension give rise to human scaring heterogeneity

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: SOMOZA, RODRIGO ALFONSO (contact)

PROJECT_TERMS: Affect;Affinity;Animals;antagonist;aptamer;Automation;Back;Biological;Biological Markers;Bioreactors;Biosensor;Cell Culture Techniques;Cell Differentiation process;Cell Fate Control;cell growth;Cell Physiology;Cell Separation;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;Complex;CRISPR-mediated transcriptional activation;Culture Media;Cultured Cells;Data;design;Development;Ensure;Environment;Event;fabrication;Feedback;Fluorescence;fluorescence imaging;Gene Expression;Generations;Genetic;Goals;Grain;Growth Factor;Harvest;Health;Heterogeneity;Human;Imaging technology;induced pluripotent stem cell;interest;Intervention;Label;manufacture;manufacturing process;Measurement;Mesenchymal Stem Cells;Microfluidics;MicroRNAs;Modernization;Modification;Molecular;Monitor;Needs Assessment;new technology;non-invasive monitor;novel;Optics;Outcome;Output;Pathway interactions;Phenotype;Population;preconditioning;Process;Production;programs;promoter;Qualifying;real time monitoring;Regenerative Medicine;Reporter;Resolution;response;scaffold;sensor;sensor technology;Signal Transduction;Site;Site-Directed Mutagenesis;small hairpin RNA;Sorting;spatiotemporal;Specificity;stem cells;System;Techniques;Technology;Testing;Tetanus Helper Peptide;Therapeutic;Time;Tissues;tool;Translating;Vertebral column;Work

PROJECT_TITLE: TR&D-1: Cell Fabrication


NIH_SPENDING_CATS: Mental Health

ORG_CITY: PROVIDENCE

ORG_STATE: RI

PHR: This application proposes a training program in computational psychiatry, an emerging field central to the NIMH mission. We propose enrolling six postdoctoral fellows who will work with a primary research mentor in a computational field and a secondary research mentor in psychiatry.

PI_NAMEs: FRANK, MICHAEL J. (contact);RASMUSSEN, STEVEN A;SERRE, THOMAS

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TITLE: Brown Postdoctoral Training Program in Computational Psychiatry


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Social Determinants of Health

PI_NAMEs: MIHALJEVIC, JOSEPH  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Algorithm Design;Algorithms;Censuses;Characteristics;Cities;cloud based;Communicable Diseases;Communities;community engagement;Community Participation;Complex;Computer software;County;COVID-19;COVID-19 pandemic;Data;Data Set;Decision Making;design;Development;Disease;disease disparity;disease model;Disease Outcome;Disease Surveillance;Disparity;Education;Education and Outreach;Educational workshop;Elements;epidemic potential;epidemiological model;Equity;Ethnic Origin;Event;Exhibits;experience;Feedback;future epidemic;future pandemic;Geographic Locations;Geography;Goals;Grain;Health;health disparity;Health equity research;Health Planning;hospitalization rates;improved;Infection;Infectious Disease Epidemiology;infectious disease model;Infrastructure;Ingestion;insight;Learning;Learning Module;Link;Localized Disease;machine learning algorithm;Methods;metropolitan;Modeling;Movement;movement analysis;Neighborhoods;new epidemic;novel;Online Systems;Outcome;Output;outreach;pandemic preparedness;Parameter Estimation;pathogen;Pattern;Persons;population stratification;Public Health;Publishing;Race;response;Series;social;social health determinants;Social stratification;sociodemographic factors;sociodemographic group;sociodemographics;socioeconomics;Spatial Design;spatial epidemiology;Standardization;Statistical Methods;statistics;Structure;Study models;Subgroup;success;symposium;Techniques;Testing;tool;Training;translational model;transmission process;Unit of Measure;Variant;web site;webinar;Workforce Development

PROJECT_TITLE: SSCIMA: Integrating Analysis of Socio-economic Sub-population Dynamics to Improve Spatial Models of Infectious Disease


PROJECT_TERMS: 3D Print;Acceleration;Affinity;aptamer;Behavior;Binding;Biochemical;Biocompatible Materials;bioink;Biological;biomaterial compatibility;Bioreactors;bioscaffold;Biosensor;Calibration;Cartilage;Cell Density;cell determination;Cell division;Cell Physiology;Cell surface;Cell-Matrix Junction;Cells;Cellular Metabolic Process;Chemistry;Citrates;Collagen;complex data;Consumption;Cues;data acquisition;data integration;data streams;Dedications;Derivation procedure;design;Detection;detection limit;detector;Development;Devices;Disparate;Dyes;Engineering;Ensure;Excision;Exhibits;fabrication;Feedback;Fiber;Fiber Optics;Fluorescence;Gel;Generations;Germ Cells;Glass;Glucose;in vitro testing;innovation;instrument;Light;Lighting;Link;Location;Mammalian Cell;manufacture;Measurement;Measures;Medial;Metabolic;Metabolic Marker;Metabolism;Methods;Molecular;Molecular Conformation;Monitor;novel;Nutrient;optical fiber;Optics;Oxygen;Performance;Process;process optimization;Production;Property;prototype;Reaction;Reagent;Reporter;Reproducibility;Resistance;scaffold;sensor;Signal Transduction;Skin;Source;Specificity;Spottings;stability testing;Standardization;Structure;Surface;System;Technology;Thick;Thinness;Time;Tissue constructs;Tissue Differentiation;Tissue Engineering;Tissue Microarray;tissue support frame;Tissues;uptake;usability;Validation;Variant;wasting;Work

PROJECT_TITLE: TR&D-2: Sensor Enabled Scaffolds


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: PROPPER, CATHERINE R (contact)

PROJECT_TERMS: Address;Arizona;Bioinformatics;Biomedical Engineering;Biometry;Catchment Area;Clinical and Translational Science Awards;Clinical Sciences;Collaborations;Communities;community engaged research;community partners;community partnership;Complement;computing resources;Core Facility;Credentialing;Data Analyses;Data Collection;data resource;Data Science;Dentistry;Development;Discipline;Discipline of Nursing;Educational workshop;Emergency Situation;Ensure;Epidemiology;Equipment;Event;Faculty;Funding;Goals;Health;health disparity;health equity;Health equity research;Housing;Human Resources;improved;incentive program;informatics infrastructure;Information Technology;Infrastructure;innovation;inter-institutional;Interdisciplinary Study;investigator training;Laboratories;laboratory equipment;laboratory facility;large scale data;Maintenance;Medicine;Methodology;Methods;Minor;Minority-Serving Institution;Mission;Modeling;multidisciplinary;Needs Assessment;novel;program dissemination;programs;Protocols documentation;public database;Public Health;Public Health Informatics;Reduce health disparities;Research;Research Activity;research and development;Research Design;research facility;research faculty;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Resources;Scanning;Science;Secure;Security;Series;Services;skills;Southwestern United States;statistics;success;Techniques;Training;training opportunity;Training Programs;translational pipeline;Translational Research;Universities;Update;Work

PROJECT_TITLE: Research Capacity Core


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: NARRATIVE The proposed “Biobehavioral Research Training to End the HIV/AIDS Epidemic” T32 is a competing continuation of the UCLA training program to prepare physician and social/behavioral scientists for academic research careers focused on integrated biomedical-behavioral (i.e., biobehavioral) approaches to HIV/AIDS prevention and treatment in diverse global settings. Despite remarkable advances in prevention of new HIV infections and treatment of HIV disease, significant challenges remain that highlight the need for integrating behavioral science and biomedical approaches. The renewal of our highly successful training program will help ensure that a new generation of scientific leaders is prepared to take us forward into the next era of HIV research, specifically by providing training to integrate behavioral and biomedical approaches to ending HIV/AIDS globally.

PI_NAMEs: CLARK, JESSE LAWTON (contact);GORBACH, PAMINA MAE

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;post-doctoral training;Prevention Research

PROJECT_TITLE: Postdoctoral Training in Global AIDS Prevention Research


NIH_SPENDING_CATS: Bioengineering;Biotechnology

PI_NAMEs: BASKARAN, HARIHARA  (contact)

PROJECT_TERMS: Address;Algorithms;Amino Acids;Autologous;Automation;Biological;Biological Markers;Bioreactors;Cell Culture Techniques;Cells;Chemicals;Culture Media;CYP1A1 gene;data management;Defect;design;Development;Ensure;extracellular;Feedback;Fiber Optics;fluid flow;Growth Factor;Health;Individual;Injections;Liquid substance;manufacture;manufacturing systems;Measurement;Measures;mechanical properties;Mechanical Stimulation;mechanical stimulus;Mechanics;Medical;Methods;Modulus;Monitor;Nutrient;optical sensor;Periodicals;Phenotype;Play;Polymers;Process;Quality Control;Regulation;Research Personnel;response;risk mitigation;scaffold;seal;sensor;Series;Shapes;Signal Transduction;Sterility;Stimulus;Surface;System;Systems Development;Technology;Temperature;Tissue constructs;Tissue Engineering;Tissues;Ultrasonics;uptake;Vertebral column;Work

PROJECT_TITLE: TR&D-3: Bio-instructive Bioreactors


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: DE HEER, HENDRIK DIRK (contact)

PROJECT_TERMS: Address;Applications Grants;Arizona;Attention;Behavior Therapy;Behavioral Research;Behavioral Sciences;Benchmarking;Biomedical Research;career;career development;Clinical;Clinical Sciences;collaborative approach;Competence;Complex;Coping Skills;Creativeness;Data;Decision Making;design;Development;disadvantaged background;Disparity;early experience;Effectiveness;Equilibrium;equity, diversity, and inclusion;ethnic minority;Evaluation;expectation;experience;Faculty;faculty mentor;Failure;Family;Feedback;Funding;Goals;Grant;Health;health equity;Health equity research;Health Occupations;Healthcare;improved;innovation;insight;Institution;institutional capacity;Justice;Mentors;Mentorship;minority communities;multidisciplinary;occupational stressor;Outcome;Outcome Measure;outreach;Peer Review;Pilot Projects;Postdoctoral Fellow;pre-clinical research;Process;Program Development;Program Evaluation;Program Research Project Grants;programs;Public Health;Publications;Qualitative Methods;racial minority;racial minority population;recruit;Research;research and development;Research Personnel;Research Support;Research Technics;Review Literature;Science;Self Efficacy;Time;timeline;Training;translational impact;Translational Research;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Investigator Development Core


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: I am reapplying for 5 years of support for mentored training and research. The proposed training and research projects address a key gap in care quality for patients with heart failure with reduced ejection fraction (HFrEF) requiring cardiac resynchronization therapy (CRT): the treatment of non-response to CRT and uncertainty in the feasibility of measuring cardiac function in these patients with cardiac MRI (CMR). We plan to prospectively assess the use of a novel cardiac pacing method with a lead placed in the left bundle branch area (LBBAP) in Veterans with HFrEF whom have been identified as CRT non-responders, and to measure cardiac function using CMR in addition to traditional echocardiography. We expect that LBBAP will result in significant improvement in cardiac function versus continued CRT, and that CMR will be an accurate and feasible method to assess cardiac function in these patients with cardiac devices. This award supports my long-term goal of using cardiac imaging to improve care of Veterans with heart failure whom require device therapy.

PI_NAMEs: CARLSON, SELMA D (contact)

PROJECT_TERMS: Address;Adult;Affect;Area;Award;Biometry;Bundle-Branch Block;Bypass;Cardiac;Cardiac conduction system;cardiac device;Cardiac health;cardiac magnetic resonance imaging;cardiac pacing;cardiac resynchronization therapy;cardiac vein;Cardiology;career;Caring;Categories;Cessation of life;Clinical;clinical care;clinical center;cost;Data;Death Rate;design;Development;Devices;Diagnostic;Diagnostic Imaging;Echocardiography;Economic Burden;effectiveness evaluation;EFRAC;Evaluation;experience;experimental study;Future;Goals;Grant;group intervention;Health Care Costs;Healthcare;Healthcare Systems;Heart;Heart failure;heart failure with reduced ejection fraction;heart function;heart imaging;Heart Rate;Hospitalization;hospitalization rates;Image;Imaging Device;implantable device;implementation science;improved;improved outcome;innovation;Institution;Interdisciplinary Study;Intervention;Intervention Trial;Investigation;K-Series Research Career Programs;Lead;Left;Left Ventricular Ejection Fraction;Left Ventricular Function;Left ventricular structure;Magnetic Resonance Imaging;Measurement;Measures;Mechanics;meetings;Mentors;Methods;Minnesota;Modality;Morbidity - disease rate;Morphologic artifacts;mortality;New York;novel;Output;Pathologic;patient oriented;patient population;patient response;Patient-Focused Outcomes;Patients;pharmacologic;Physiological;Population;post intervention;prospective;Protocols documentation;Quality of Care;Quality of life;Randomized;randomized, controlled study;Randomized, Controlled Trials;Reproducibility;Research;Research Activity;Research Personnel;Research Project Grants;Research Training;Right ventricular structure;Risk;skills;standard care;sudden cardiac death;symptomatic improvement;Symptoms;System;Techniques;Therapeutic;Time;Tissues;Training;training project;treatment group;Uncertainty;Universities;Ventricular;Ventricular septum;Veterans;Veterans Health Administration

PROJECT_TITLE: Evaluation of Left Bundle Branch Area Pacing As A Rescue Strategy for Cardiac Resynchronization Therapy Non-response in Patients With Heart Failure: A Randomized Controlled Trial


PI_NAMEs: BOLLENBACH, THOMAS  (contact)

PROJECT_TERMS: 3-Dimensional;Acoustics;Agitation;Aliquot;Architecture;articular cartilage;Automation;Biological Markers;biophysical properties;Bioreactors;Biosensor;Cartilage;Cell Culture System;Cell Culture Techniques;Cells;Complex;Computer-Aided Design;Core Facility;cost effective;Data;data acquisition;Data Management Resources;design;Development;Elements;Engineering;Ensure;Environment;Equipment;Evolution;fabrication;Feedback;Goals;Good Manufacturing Process;Guidelines;Harvest;improved;Knowledge;Logic;Manuals;manufacture;manufacturing systems;Measurement;Measures;Mechanics;Microfluidics;Modeling;Modification;Monitor;next generation;Nutrient;Optics;Organ;Play;preservation;Process;Production;prototype;Regenerative Medicine;Research Personnel;Running;Sampling;Scientist;Secure;sensor;sensor technology;Specific qualifier value;Sterility;System;Time;tissue culture;Tissue Engineering;Tissues;tool;Training;Translating;translational goal;Vertebral column;Vial device

PROJECT_TITLE: TR&D-4: Growing Tissue in the Scalable, Modular, Automated, and Closed (SMAC) Foundry


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: SABO, SAMANTHA JANE (contact)

PROJECT_TERMS: Accountability;Address;Advisory Committees;Affect;American Indians;Arizona;Awareness;behavioral health;Clinical;Collaborations;Communication;Communities;community academic partnership;community building;community engaged research;community engagement;Community Health;Community Medicine;community organizations;Consensus;Development;Discrimination;Dissemination and Implementation;dissemination strategy;Economics;Engineering;Equity;Evaluation;evidence base;experience;Faculty;Fostering;Foundations;Geography;Goals;Health;health disparity;health equity;Health equity research;health inequalities;Hispanic;Inequity;Information Centers;Information Dissemination;Interactive Systems Framework;interest;Intervention;Justice;Latinx;member;Mentors;Mexico;Modeling;multimodality;Pathway interactions;Pilot Projects;Policies;Population;population health;Population Heterogeneity;Poverty;Preparation;program dissemination;programs;public-private partnership;Research;Research Infrastructure;Research Personnel;Research Project Grants;Rural;Signal Transduction;social;social determinants;social health determinants;Southwestern United States;Strategic Planning;Structural Racism;Surveys;System;Translating;Translational Research;Translations;Tribes;United States;United States National Academy of Sciences;United States National Institutes of Health;Universities;University resources;Vision

PROJECT_TITLE: Community Engagement Core


PI_NAMEs: BALDWIN, JULIE ANN (contact)

PROJECT_TERMS: Administrator;Area;Arizona;Behavioral Sciences;Biomedical Engineering;Black American;Budgets;career;Chronic;Clinical;Clinical Sciences;Communication;Communities;community engagement;Community Health;community partners;Core Facility;Degree program;design;Development;disadvantaged background;Discipline;Doctor of Philosophy;early onset;Environment;Equity;equity, diversity, and inclusion;Expenditure;experience;Faculty;faculty mentor;Family;formative assessment;Funding;Gender;Goals;Health;health economics;health equity;Health equity research;Health Occupations;Health Services Research;Hispanic Americans;Individual;Informatics;Institution;Justice;Leadership;member;Mentors;Mexican Americans;Mission;Native Americans;Occupational Therapy;Persons;Physical therapy;Physician Assistants;population health;Positioning Attribute;Productivity;programs;Public Health;Public Health Informatics;Qualifying;racism;Records;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Resources;Science;senior faculty;Sexuality;social stigma;Societies;Southwestern United States;Strategic Planning;Stress and Coping;structural health determinants;success;tenure track;Training;Translational Research;Underrepresented Populations;United States National Institutes of Health;Universities;Wages;Work;Writing

PROJECT_TITLE: Recruitment Core


PROJECT_TITLE: Training and Dissemination


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: SANTA CRUZ

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative Comprehensive profiling of DNA and RNA molecules, including nucleotide modifications, is important for a complete understanding of how genes are normally regulated or dysregulated in disease; however, this requires methods for higher resolution profiling than what is currently available by standard sequencing techniques. To this end, we will develop approaches using long-read technology to simultaneously detect in vivo genome-wide DNA modification and accessibility and correlate changes with complete RNA sequences, along with RNA modifications. We will apply our approaches to the study of well-characterized biological responses known to impact chromatin in established mammalian cell lines and probe the inter-dependence of the epigenome and epitranscriptome by suppressing expression of key protein modulators.

PI_NAMEs: BROOKS, ANGELA NORIE (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Affect;base;Biological;Biomedical Research;Cell Line;Chromatin;chromatin remodeling;Chromatin Structure;Detection;Disease;DNA;DNA Modification Process;epigenome;epigenomic profiling;epigenomics;epitranscriptome;epitranscriptomics;Event;experimental study;Gene Expression Regulation;Genes;Genetic Fingerprintings;genome sequencing;genome-wide;improved;in vivo;knock-down;Length;Mammalian Cell;Methods;Modification;Molecular;Molecular Profiling;nanopore;novel strategies;Nucleotides;Protein Isoforms;protein phosphatase inhibitor-2;Resolution;response;RNA;RNA Editing;RNA Processing;RNA Sequences;RNA-Binding Proteins;Signal Transduction;Stretching;Techniques;Technology;Testing;tool;transcriptome;transcriptome sequencing

PROJECT_TITLE: A novel approach to improve comprehensive profiling of the epigenome and epitranscriptome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: NEUROSURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative:  Parkinson’s disease (PD) is a debilitating neurodegenerative disorder that disrupts proper movement control and motor learning. Motor control and skilled motor learning are regulated by the striatum, which integrates excitatory inputs in the form of glutamate from the cortex and thalamus. This proposal uses interdisciplinary approaches to identify the mechanisms that determine the synaptic plasticity in the striatum, and results from these studies aim to generate a better mechanistic understanding of how dopamine and loss of dopamine alter the striatal function, ultimately to provide potential new therapeutic avenues for PD.

PI_NAMEs: DING, JUN  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Affect;Axon;Basal Ganglia;Behavior;Behavioral;Brain;cell type;Corpus striatum structure;Disease;Dopamine;effective therapy;Electric Stimulation;Electrophysiology (science);experimental study;Funding;Future;Gene Expression;Genetic;Genetic Recombination;Glutamates;Goals;Image;Immediate-Early Genes;Impairment;in vivo;interdisciplinary approach;L-DOPA induced dyskinesia;Label;Learning;Lesion;loss of function;Mediating;Memory;Molecular;Molecular Profiling;Motor;Motor Activity;motor behavior;motor control;Motor Cortex;motor learning;motor skill learning;Motor Skills;Movement;Movement Disorders;Mus;N-Methyl-D-Aspartate Receptors;nerve supply;neural correlate;Neurodegenerative Disorders;Neuronal Plasticity;Neurons;novel therapeutics;Output;Parkinson Disease;Pattern;Population;prevent;promoter;Role;single-cell RNA sequencing;Structure;success;Synapses;Synaptic plasticity;Thalamic structure;tool;two-photon;Vertebral column;Visualization

PROJECT_TITLE: Dopamine modulation of synaptic plasticity and integration in the striatum

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The goal of this study is to develop a new paradigm of deep learning that combines medical imaging data and clinical knowledge to augment breast cancer diagnosis, risk assessment, and lesion detection. This study will contribute major technical innovations for deep learning on small datasets, longitudinal examinations, and content-efficient images, not only to breast imaging, but also applicable/extendable to other diseases/organs. New algorithms, tools, and source code will be provided to advance research and clinical applications.

PI_NAMEs: WU, SHANDONG  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Address;Algorithms;Artificial Intelligence;Biological;biomedical imaging;breast cancer diagnosis;Breast Cancer Risk Factor;breast imaging;cancer imaging;Clinical;clinical application;clinical imaging;Clinical Sciences;Computational Technique;Data;Data Set;deep learning;deep learning model;design;Detection;Development;Devices;Disease;Engineering;experience;Goals;Image;imaging modality;innovation;insight;Knowledge;Lesion;Malignant Breast Neoplasm;Maps;Medical;Medical Imaging;Methodology;Methods;Modeling;multidisciplinary;novel;novel strategies;Organ;Patients;Research;Research Personnel;Risk Assessment;risk prediction;Source Code;Structure;success;Technology;tool;Training;trustworthiness

PROJECT_TITLE: SCH: Leverage clinical knowledge to augment deep learning analysis of breast images

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cancer;Genetics;Nutrition;Skin Cancer

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Melanocyte development involves both extensive proliferation and the formation of a large number of dendrites. Both of these processes are likely to require high levels of fatty acids, however, the mechanism through which melanocytes access fatty acids during development is not known. This study aims to determine how melanocytes acquire fatty acids during differentiation and what role these fatty acids play in proper melanocyte development and function.

PI_NAMEs: JOHNS, ELEANOR  MAY (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Adipocytes;Affect;Apoptosis;Binding Proteins;Cell Lineage;Cell membrane;cell motility;Cell Proliferation;cell type;Cells;Chemicals;Communication;CRISPR/Cas technology;Data;Defect;Dendrites;Dendritic Cells;Development;Disease;Embryo;Embryonic Development;Environment;Enzymes;Event;experimental study;FABP3 gene;Family;Family member;fatty acid metabolism;fatty acid oxidation;fatty acid transport;fatty acid-transport protein;Fatty Acids;Fluorescence Microscopy;Gene Expression;Genes;Genetic;genetic manipulation;Genetic Transcription;Genus Hippocampus;Germ Lines;human pluripotent stem cell;Hyperpigmentation;Image Analysis;in vitro Model;in vivo;in vivo Model;Injections;insight;Invaded;Investigation;keratinocyte;Knock-out;Label;Lecithin;lipid metabolism;Lipids;Measures;melanoblast;melanocyte;Melanoma;Melanoma Cell;Membrane;Metabolic;Metabolism;Methods;migration;Mitochondria;Modeling;Morphology;Neural Crest;Nonesterified Fatty Acids;novel;Oncogenic;oxidation;Pathway interactions;Pattern;Pattern Formation;Phenotype;Phosphatidylethanolamine;Phospholipids;Pigmentation Disorders;Pigmentation physiologic function;Play;Process;Production;Proliferating;promoter;Protein Family;Protein Inhibition;Proteins;Role;sensor;Signal Transduction;Skin;Skin Cancer;Skin Pigmentation;Source;Supporting Cell;System;Testing;tumor microenvironment;ultraviolet damage;uptake;UV protection;Variant;Work;Zebrafish

PROJECT_TITLE: Investigating the role of fatty acid metabolism in melanocyte differentiation: Insights into the metabolic requirements of development


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is a devastating, progressive, neurodegenerative disease that affects millions of Americans, yet there is no cure, and there are very limited treatment options. As the blood brain barrier (BBB) blocks nearly all drugs from entering the central nervous system, ultrasound contrast agents activated by ultrasound are being explored to transiently open the BBB and enhance drug delivery to the brain. This proposal will determine the mechanisms by which ultrasound contrasts agents open the BBB and use this drug delivery strategy to ultimately increase the number of therapeutic candidates that can be delivered to the brain for the treatment of AD and other neurologic diseases.

PI_NAMEs: CONWAY, GRACE  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Adherens Junction;Adverse effects;Affect;aging population;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;American;Antibodies;Area;Astrocytes;bench-to-bedside translation;beta-site APP cleaving enzyme 1;Biology;Blood - brain barrier anatomy;Blood capillaries;Blood Vessels;blood-brain barrier permeabilization;Brain;brain circulation;brain endothelial cell;Calcium;career;career development;Caregivers;Cells;Central Nervous System;clinical translation;Coculture Techniques;cognitive ability;cognitive function;Combined Modality Therapy;Confocal Microscopy;Contrast Media;Cytoskeleton;Data Analyses;Deposition;design;Development;Dextrans;Disease;Dose;Drug Delivery Systems;Drug Design;Drug Modelings;Drug usage;Electrical Resistance;Endothelial Cells;Endothelium;Enzymes;Event;Experimental Designs;experimental study;Failure;Family;FDA approved;Goals;Healthcare Systems;human old age (65+);Image;Impaired cognition;improved;In Vitro;in vivo;inhibitor;insight;Intravenous;Liver;Mediating;meetings;Mentors;Microbubbles;Microbubbles Ultrasound Contrast Medium;Microcirculation;Modeling;Molecular;Monitor;mouse model;multidisciplinary;Mus;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;novel therapeutic intervention;novel therapeutics;Patients;Penetration;Permeability;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Phase I Clinical Trials;Phase II Clinical Trials;Physicians;Physics;Physiology;Pittsburgh Compound-B;Plasma;Positron-Emission Tomography;Proteins;Research Project Grants;Scientist;side effect;Signal Transduction;Site;sonoporation;Statistical Data Interpretation;Stress;Structure;Suspensions;symptom management;Techniques;Testing;theranostics;Therapeutic;therapeutic candidate;Tight Junctions;Training;Translational Research;Ultrasonic Transducer;ultrasound;Umbilical vein

PROJECT_TITLE: Treatment of Alzheimer’s Disease using Ultrasound-Targeted Microbubble Cavitation-Mediated Blood Brain Barrier Opening to Facilitate Drug Delivery to the Brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-Y(20)L]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Dietary Supplements;Digestive Diseases;Microbiome;Nutrition;Obesity;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative: Excess body weight is associated with metabolic dysfunction, including insulin resistance and chronic inflammation, and with increased risk for chronic disease including colon cancer. We propose a 12-month randomized controlled (RCT) dietary intervention to investigate our hypothesis that restoring the natural high fiber content of the western diet with natural foods, including legumes such as dry beans, will have a multi- modal effect on suppressing the elevated colon cancer risk in high risk overweight/obese post-polypectomy volunteers by inducing weight loss, suppressing systemic inflammatory responses, and by stimulating the colonic microbial production and release of antineoplastic metabolites. Should our hypotheses prove correct, our methods could be used in other high-risk populations at risk for colon cancer.

PI_NAMEs: HARTMAN, TERRYL J. (contact);O'KEEFE, STEPHEN J.D.

PROGRAM_OFFICER_NAME: EMENAKER, NANCY J

PROJECT_TERMS: adenoma;Adenomatous Polyps;African;African American population;Antineoplastic Agents;Apoptosis;arm;Atherosclerosis;bean;Behavior;Behavior Therapy;Bile Acids;Biochemical Markers;Biological;Biological Markers;Body mass index;Body Weight;Body Weight decreased;C-reactive protein;Calories;cancer biomarkers;cancer risk;carcinogenicity;Carcinogens;CD3 Antigens;Cd68;Cell Proliferation;Chinese;Chronic;Chronic Disease;Colon;colon cancer prevention;colon cancer risk;Colon Carcinoma;Colonoscopy;Colorectal Cancer;colorectal cancer risk;Communities;Consumption;Controlled Clinical Trials;Controlled Study;Depressed mood;design;Diet;Diet Modification;dietary;dietary control;Dietary Intervention;Disease;Dryness;Education;Energy Intake;Epidemiology;Equilibrium;experience;Fabaceae;Fasting;Fatty acid glycerol esters;Female;Fermentation;Fiber;Food;food consumption;Gastroenterology;Gastrointestinal Motility;Gastrointestinal Transit;Germ-Free;Glucose;Goals;gut microbiota;Health;high risk;high risk population;High-Risk Cancer;Incidence;Inflammation;Inflammatory;Instruction;Insulin;Insulin Resistance;insulin signaling;Intake;Intervention;intervention participants;Intervention Studies;intraepithelial;Investigation;Lentils - dietary;Link;Lipids;Longterm Follow-up;Lymphocyte;Macrophage;Maintenance;male;Malignant Neoplasms;Measures;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolome;Methods;Microbe;microbial;microbiome;microbiota;middle age;Modification;Monitor;mortality;Mucous Membrane;multimodality;Mus;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Nutritional;Obesity;Outcome;Overweight;Participant;Patients;Pattern;Phase;Phytochemical;Plants;Plasma;Polypectomy;Polyps;Population;Population Heterogeneity;Population Intervention;Populations at Risk;prevent;Production;programs;Public Health;Publishing;Randomized;randomized, clinical trials;Recording of previous events;recruit;Reporting;Research;response;Risk;Risk Factors;Satiation;Science;Self Direction;Serum;Speed;systemic inflammatory response;Testing;Therapeutic;Time;volunteer;Weight;Weight Gain;Weight maintenance regimen;western diet

PROJECT_TITLE: Fiber-rich Foods to Treat Obesity and Prevent Colon Cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

ORG_CITY: BIRMINGHAM

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: “Describe the relevance of this research to public health in, at most, three sentences.” The network's overall goal is to do science that is immediately applicable to everyday clinical practice, to foster movement of its findings into everyday clinical practice, and thereby improve the health of the nation. The network will continue to be a highly collaborative environment wherein clinicians in everyday clinical practice, academic researchers, patient representatives, and their communities become engaged in “win-win” activities that each group sees as mutually beneficial and which improves health.

PI_NAMEs: GILBERT, GREGG H (contact)

PROGRAM_OFFICER_NAME: FISCHER, DENA

PROJECT_TERMS: Achievement;Alabama;Belief;Chicago;Clinical;clinical decision-making;clinical implementation;clinical practice;Clinical Research;Clinical Trials Data Monitoring Committees;collaborative environment;Communication;Communities;Compensation;Data;Data Collection;Dental;Dental Care;Dental General Practice;Dental Specialties;Development;Dissemination and Implementation;Effectiveness;effectiveness study;electronic data;Elements;Ensure;Environment;evidence base;experience;flexibility;Florida;Fostering;Funding;Funding Mechanisms;Geographic Locations;Goals;Growth;Health;Health Sciences;Human Resources;Illinois;improved;Infrastructure;Institutional Review Boards;interest;journal article;Journals;Learning;Manuscripts;Measures;medical specialties;Movement;National Institute of Dental and Craniofacial Research;Office Visits;operation;Oral health;patient advocacy group;Patient Care;Patient Recruitments;Patient Representative;patient retention;Patients;Peer Review;Performance;Phase;Process;Productivity;protocol development;Public Health;public-private partnership;Publications;recruit;Research;Research Personnel;research study;research to practice;Resources;routine practice;Scandinavia;Science;Special Population;Specific qualifier value;Standardization;Structure;System;Texas;Text;Training;Translational Research;United States;Universities;Work

PROJECT_TITLE: The National Dental PBRN Administrative and Resource Center


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE The overarching mission of our research is to elucidate how transcription and spatial location influence fine-scale features of genome folding. We will accomplish this goal by using both established and innovative genomics and bioinformatics to track the progress of chromatin interactions during transcription and in nuclear space. This work will resolve long-standing mechanistic questions and provide new computational and wet-lab tools for investigating genome architecture at unprecedented resolution.

PI_NAMEs: ROWLEY, MICHAEL JORDAN (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TITLE: Fine-Scale Genome Folding Relative to Transcription and Location

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease

PROJECT_TERMS: Address;administrative database;Caring;Clinical;clinical decision-making;clinical practice;Clinical Research;Collaborations;Community of Practice;Consensus;Data;Decision Making;Dental;Dental Care;Dentistry;Development;Enrollment;experience;Face;Feedback;Fostering;Future;Geographic Distribution;Goals;Healthcare Systems;implementation process;improved;Information Dissemination;insight;Interview;Knowledge;Lead;meetings;Methods;Modeling;Movement;National Institute of Dental and Craniofacial Research;Newsletter;operation;organizational structure;Patient Care;Patients;Personal Satisfaction;Play;population health;Process;Professional Organizations;Questionnaires;recruit;Reporting;Research;Research Assistant;research study;research to practice;Resources;Respondent;response;Role;routine practice;Source;success;Testing;Text;Time;Training;Work

PROJECT_TITLE: The National Dental PBRN - Administrative Core


ADMINISTERING_IC: FD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: ITHACA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative The AHDC wishes to continue its cooperative agreement with the FDA Vet-LIRN and the Vet-LIRN network of veterinary diagnostic laboratories to promote the areas of food and feed surveillance, method development and standardization, quality management, and provide surge capacity for large-scale testing in the event of an emergency. The Analytical Toxicology section of the AHDC intends to continue cooperative activities with the FDA Vet-LIRN, the Vet-LIRN network, and federal, state, local and tribal organizations to promote animal health and feed and food safety and security.

PI_NAMEs: BISCHOFF, KARYN  (contact)

PROGRAM_OFFICER_NAME: CERIC, OLGICA

PROJECT_TITLE: Animal Feed and Pet Food Safety Cooperative Agreement with FDA/VET-LIRN


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE HIV continues to be a major cause of death and suffering worldwide. Our program supports training of early career stage investigators to become independent, patient-based and translational scientists addressing the highest impact research questions in HIV that are designed to reach affected populations. Building on the successful outcomes of our prior training program, we aim to train the next generation of researchers in HIV biomedical prevention, novel treatments and cure research.

PI_NAMEs: HAVLIR, DIANE V (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: HIV;Training;Translational Research

PROJECT_TITLE: Training in HIV Translational Research

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Public Health Relevance Statement The proposed research is relevant to public health because heart failure-associated morbidity and mortality represent a major economic and health burden. The study will define the role of asporin, an extracellular matrix protein, in mediating protective effects to heart. In addition, the objective of this project is to develop new asporin- based therapies to reduce cardiac injury and adverse cardiac remodeling.

PI_NAMEs: PARKER, SARAH J (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Address;adeno-associated virus 9 delivery;Anabolism;Angiotensin II;asporin;Autophagocytosis;biglycan;Binding;Biological;Biology;Blood flow;Cardiac;Cardiac Myocytes;cell behavior;Cell Death;Cell Death Induction;Cell Survival;cell type;Cells;Cicatrix;Core Protein;coronary fibrosis;decorin;Degenerative polyarthritis;Deposition;design;Economics;Exhibits;Extracellular Matrix;Extracellular Matrix Proteins;Extracellular Protein;Fibrillar Collagen;Fibroblasts;Fibrosis;Functional disorder;Genes;Glycosaminoglycans;Glycosphingolipids;Goals;Grant;Health;Heart;Heart Block;Heart failure;heart function;Heart Injuries;Hypertrophy;Hypoxia;improved;In Vitro;in vivo;Infarction;inhibitor;innovation;insight;Investigation;ischemic injury;Knockout Mice;Leucine;Ligands;Link;Macrophage;Malignant Neoplasms;Mediating;Metabolic;metabolic profile;metabolome;Modification;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Ischemia;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Osteoporosis;Pathologic;Pathway interactions;Patients;peptide drug;Peptides;Play;pleiotropism;pressure;prevent;Process;protective effect;Proteins;Proteoglycan;Public Health;public health relevance;purine metabolism;Pyrimidine;receptor;Recombinants;Regulation;Reperfusion Injury;Research;response;Role;Signal Transduction;Stress;Testing;therapeutic evaluation;Therapeutic Intervention;therapeutic target;therapeutically effective;Transforming Growth Factor beta;Treatment Efficacy

PROJECT_TITLE: Asporin, an extracellular protein, regulates cardiac remodeling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: LEXINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE This study would have critical implications for the pathophysiology of numerous CNS conditions, and help reconcile mixed results with anti-IL-1 therapeutics and inform new IL-1 modulation strategies. Moreover, defining the role of neuronal IL-1R1 signaling would provide a new neuroprotective approach, as well as enable the development of new formulations of existing IL-1 targeted interventions to preserve the neuroprotective functions of IL-1.

PI_NAMEs: BACHSTETTER, ADAM D (contact);NORRIS, CHRISTOPHER MARK

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acute;Address;Age;Animal Disease Models;Anti-Inflammatory Agents;Attention;Autoimmune Diseases;Axon;Behavior;Behavioral Assay;Brain;cell type;Cells;Chronic;Closed head injuries;cognitive function;cognitive recovery;Complex;cytokine;Data;Development;Electrophysiology (science);Exhibits;experimental study;FDA approved;Formulation;Functional disorder;Gene Expression Profile;Genes;genetic approach;Goals;inducible Cre;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;Injury;Interleukin Suppression;Interleukin-1;interleukin-1 receptor accessory protein;Interleukin-1 Receptors;Intervention;knock-down;Knockout Mice;Knowledge;LoxP-flanked allele;Maintenance;Mediating;Memory;Modeling;mouse model;Mus;Nature;Nerve Degeneration;nerve injury;Nervous System Disorder;Nervous System Trauma;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurons;neuroprotection;neuroregulation;novel;Pathway interactions;Peripheral;Phase;Phenotype;Physiology;preservation;Process;Receptor Signaling;Recovery;response;RiboTag;Role;Signal Transduction;Synapses;synaptic function;Synaptic plasticity;System;Testing;Therapeutic;Tissues;Traumatic Brain Injury

PROJECT_TITLE: Neuronal IL-1R1 Signaling in Mild Closed Head Injury

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative By developing and applying new, advanced tools and methods in electron diffraction, we aim to facilitate the determination of new structures from macromolecular assemblies. To achieve this, we have assembled a team of experts in cryoEM, crystallography, biochemistry and computation that will establish MicroED as an accessible tool for experts and novices alike. With a focus on method development tested on driving biological projects, community engagement through workshops, symposiums, collaborations and one on one training, we forecast that our MicroED resource would have a long and lasting impact on biomedical research.

PI_NAMEs: GONEN, TAMIR  (contact);NANNENGA, BRENT

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: 3-Dimensional;Automobile Driving;Biochemistry;Biological;Biomedical Research;Categories;Collaborations;community engagement;Country;Coupled;Cryoelectron Microscopy;Crystallization;Crystallography;Development;Disease;Educational workshop;electron diffraction;Electron Diffraction Microscopy;Electrons;Engineering;experience;Goals;Growth;Human Resources;imaging facilities;improved;innovation;Institution;instrument;instrumentation;Life;Light;macromolecular assembly;Macromolecular Complexes;method development;Methodology;Methods;Modality;Molecular Biology;Molecular Structure;nano;nanocrystal;nanoscale;Natural Products;next generation;novel;novel therapeutics;Phase;Preparation;Procedures;programs;protein structure;Resolution;Resources;Roentgen Rays;Sampling;screening;small molecule;Structure;symposium;System;Technology;technology development;Testing;Time;tool;Toxin;Training;Visible Radiation;X ray diffraction analysis

PROJECT_TITLE: MEDIC - MicroED Imaging Center at UCLA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(40)P]


PI_NAMEs: GONEN, TAMIR  (contact)

PROJECT_TERMS: Advisory Committees;Automobile Driving;Biological;Budgets;Chemistry;Communication;community engagement;Computing Methodologies;Cryoelectron Microscopy;Crystallography;Educational workshop;electron diffraction;Eligibility Determination;Ensure;experience;Fostering;Funding;Goals;Grant;Human Resources;image reconstruction;imaging facilities;improved;Instagram;Joints;Leadership;Maintenance;Medical center;meetings;member;Methodology;Micro Electron Diffraction;Mind;Mission;Molecular Structure;nano;Natural Products;news;Online Systems;particle;Persons;Post-Translational Protein Processing;Preparation;Principal Investigator;Procedures;programs;Progress Reports;Protocols documentation;Qualifying;Recommendation;Reporting;Research;Research Activity;research and development;Research Personnel;Research Support;Resolution;Resource Sharing;Resources;Role;Schedule;Secure;Site;social media;structural biology;Structure;Suggestion;Synchrotrons;Techniques;Technology;technology development;technology research and development;Teleconferences;Training;Twitter;United States National Institutes of Health;Update;web site;X-Ray Crystallography

PROJECT_TITLE: MEDIC - MicroED Imaging Center - Admin Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SEATTLE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Retinal pigment epithelial (RPE) cells have unique metabolic requirements that are perturbed in disease states. Findings from our studies will provide a framework for understanding how extracellular matrix dysregulation leads to increased lipid generation and reduced anti-oxidative capacity in human RPE cells. These studies will expedite the understanding of the underlying causes of RPE-related disease and facilitate treatment discovery.

PI_NAMEs: CHAO, JENNIFER RAYMING (contact);DU, JIANHAI

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Acids;Affect;Age related macular degeneration;Autopsy;Biochemical;Biological Assay;Biology;Branched-Chain Amino Acids;Buffers;Cell Respiration;Cells;Clinical;comparison control;CRISPR/Cas technology;Data;Degenerative Disorder;Deposition;Development;Disease;Drusen;Energy Metabolism;Exhibits;Extracellular Matrix;Extracellular Matrix Degradation;Generations;Genes;Glucose;Glutathione;Glutathione Metabolism Pathway;Goals;Human;human disease;Impairment;induced pluripotent stem cell;inherited retinal degeneration;ketogentic;lipid metabolism;Lipids;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;Mutation;NADP;novel strategies;Nuclear RNA;nutrient metabolism;Outcome;oxidation;Oxidation-Reduction;oxidative damage;Oxidative Stress;Pathologic;patient derived induced pluripotent stem cells;Production;programs;Protein Biosynthesis;protein degradation;Proteomics;Research;Resources;Role;Sorsby's fundus dystrophy;Stress;stressor;Structure of retinal pigment epithelium;sugar;Testing;Thinness;TIMP3 gene;transcriptome sequencing;treatment strategy

PROJECT_TITLE: Metabolic dysfunction from ECM remodeling in diseases of human RPE

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


PI_NAMEs: EISENBERG, DAVID  (contact)

PROJECT_TITLE: TRD1: Dedicated sample preparation for MicroED


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Nanotechnology;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative The successful development and translation of the proposed STICK nano-delivery platform will have a significant impact on the clinical management of diffuse midline glioma (DMG) as well as many other brain malignancies. This will be accomplished by minimizing drug release into normal tissues and limiting off-target toxicity, while maximizing tumor cell-specific drug delivery to DMG, thus dramatically enhancing therapeutic efficacy and minimizing off-target toxicity. The team of experts in pediatric neuro-oncology (Drs. Antony & Monje) and epigenetics in pediatric glioma (Dr. Knoepfler) will provide comprehensive expertise to facilitate the clinical development of the proposed novel targeting and transformable nano-theranostics that will ultimately benefit many patients with DMG.

PI_NAMEs: LI, YUANPEI  (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Acidosis;Acids;Address;Binding;Biodistribution;biophysical techniques;Blood;Blood - brain barrier anatomy;Blood Circulation;blood-brain barrier crossing;blood-brain tumor barrier;Boronic Acids;Brain;Brain Neoplasms;Cell surface;Central Nervous System;Characteristics;Child;Childhood;Childhood Glioma;Circulation;Clinical;clinical development;Clinical Management;crosslink;design;Development;Diagnosis;Diffuse intrinsic pontine glioma;diffuse midline glioma;Disease;Drug Delivery Systems;Drug Kinetics;Drug Targeting;Encapsulated;Endothelium;Engineering;Ensure;epigenetic drug;Epigenetic Process;epigenetic therapy;Excision;Feasibility Studies;Genetically Engineered Mouse;Glioblastoma;Glucose;Glucose Transporter;glycemic control;Glycoproteins;Goals;Grant;Heterogeneity;Histology;Histones;image guided;image-guided drug delivery;imaging agent;Immunotherapeutic agent;improved;in vivo;liquid chromatography mass spectrometry;Lysine;Magnetic Resonance Imaging;Malignant Neoplasms;Mediating;Metastatic malignant neoplasm to brain;Methionine;Microdialysis;Modeling;Molecular;molecular drug target;molecular imaging;Monitor;mouse model;Mutation;Nanodelivery;nanoparticle;nanotechnology platform;nanotheranostics;neoplastic cell;Nervous System Disorder;neuro-oncology;Normal tissue morphology;novel;optical imaging;Outcome;overexpression;patient derived xenograft model;Patients;Penetration;Pharmaceutical Preparations;Physiological;premature;Radiation;Research;response;Scheme;Series;Sialic Acids;Site;spatiotemporal;Specificity;Surface;Survival Rate;Symptoms;theranostics;Therapeutic;Therapeutic Index;Therapeutic Use Study;therapeutically effective;three-dimensional modeling;Time;Tissues;Toxic effect;transcytosis;Translations;Treatment Efficacy;Treatment-related toxicity;tumor;Tumor Burden;tumor microenvironment;tumor progression;tumor specificity;Tumor Tissue;tumor-specific gene delivery;uptake

PROJECT_TITLE: A “STICK” theranostic nanoplatform for image-guided drug delivery to brain malignancies

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Biotechnology

PI_NAMEs: PENCZEK, PAWEL A. (contact)

PROJECT_TERMS: absorption;Acceleration;Adopted;Biological Assay;Computer software;computerized data processing;Crystallization;Data;Data Analyses;Data Collection;Dedications;detector;Development;Diffusion;Dose Fractionation;Electron Beam;electron diffraction;Electron Diffraction Microscopy;Electron Microscopy;Electrons;experimental study;Exposure to;foot;Fourier Transform;Frequencies;Heavy Metals;Homologous Gene;Image;imaging facilities;ionization;Lead;Methodology;Methods;microscopic imaging;Modality;Modeling;Modification;Molecular;nanocrystal;Pattern;Phase;Physics;Procedures;Process;protein structure;Proteins;Radiation induced damage;Reagent;Resolution;Roentgen Rays;Sampling;Signal Transduction;small molecule;Spottings;Statistical Distributions;Statistical Methods;statistics;Structure;System;Technology;tool;voltage;Work;X-Ray Crystallography

PROJECT_TITLE: TRD2: Phasing and refinement


NIH_SPENDING_CATS: Biotechnology;Natural Products

PROJECT_TERMS: Address;Amino Acids;analytical method;analytical tool;Bacterial Genome;Binding;Biological Assay;Cessation of life;Collection;Communities;Crystallization;Databases;design;Development;drug development;drug discovery;Drug Industry;electron diffraction;Electron Diffraction Microscopy;Evaluation;Fungal Genome;Goals;Growth;Human Resources;imaging facilities;inhibitor;Ion Channel;Laboratories;Lead;Libraries;Life;Maps;Medicine;Methodology;Methods;nanocrystal;Natural Product Drug;Natural Products;nerve agent;Neurotoxins;Neutron Diffraction;Paralysed;Peptides;Pharmaceutical Preparations;polypeptide;Powder dose form;Preparation;Procedures;Process;Proteins;receptor;Resolution;Ribosomes;Roentgen Rays;Sampling;small molecule;Specimen;Structure;Techniques;Technology;Time;Toxin;X-Ray Crystallography

PROJECT_TITLE: TRD3: Peptide inhibitors and small molecule drug discovery


NIH_SPENDING_CATS: Bioengineering;Biotechnology

PI_NAMEs: SPENCE, JOHN CHARLES (contact)

PROJECT_TITLE: TRD4: Design and Engineering of MicroED hardware for nanocrystallization and time resolved studies


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking

PHR: Project Narrative This study examines the influence of sociodemographic statuses and transitions among those now entering midlife on comorbid health outcomes in early midlife, as well as the role of life-course alcohol use and social and neighborhood environments for midlife health. Drawing on longitudinal data from a diverse community sample from age 10 to 47, the study investigates the long-term malleability of environmental factors and seeks to identify promising intervention targets to design and tailor prevention programs from early adolescence to midlife. The goal of the study is to provide midlife researchers and health practitioners with specific recommendations for preventive interventions addressing public health priorities for midlife adults.

PI_NAMEs: EPSTEIN, MARINA  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Address;Adolescence;Adult;Affect;Age;Alcohol consumption;alcohol misuse;Alcohols;Attention;Behavior;Biological Markers;Career Choice;Censuses;Child Rearing;Childhood;cognitive function;cohort;Communities;comorbidity;COVID-19 pandemic;Data;Data Collection;design;Development;disability;Disease;Disparity;early adolescence;Education;elementary school;emotional experience;Environment;Environmental Risk Factor;experience;Family;Focus Groups;Frequencies;Friends;Gender;Generations;Goals;Health;Health behavior;human old age (65+);Impairment;improved;innovation;Intervention;intervention effect;Investigation;Knowledge;Label;late life;Life;Life Cycle Stages;Link;Long-Term Effects;Longitudinal Studies;Measures;Mental Health;middle age;multi-ethnic;Neighborhoods;Outcome;Participant;Patient Self-Report;physical conditioning;prevent;Prevention program;preventive intervention;professional atmosphere;programs;prospective;protective factors;Public Health;public health priorities;Recommendation;reduced alcohol use;Research;Research Personnel;Risk;Risk Factors;Role;Sampling;school environment;social;Social Development;Social Environment;sociodemographics;socioeconomics;Stress;substance use;Substance Use Disorder;Testing;theories;therapy design;Translating;uptake;Work

PROJECT_TITLE: Health and Functioning in New Midlife Adults: Understanding the Role of Alcohol Use, Social Environments, and Preventive Intervention over the Life Course

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


PROJECT_TERMS: Address;Affect;Antibodies;Automobile Driving;Biochemistry;Biomedical Research;Capsid Proteins;Charge;Chemistry;Communication;Complex;Cryoelectron Microscopy;Crystallization;Development;DNA;drug discovery;Drug Targeting;electron diffraction;Electron Diffraction Microscopy;experience;Family;G-Protein-Coupled Receptors;Gene Expression;HIV-1;imaging facilities;interest;Ligands;Medicine;Membrane Proteins;Membrane Transport Proteins;Molecular Conformation;Natural product discovery;Natural Products;neurotransmission;Nutrient;Porosity;protein complex;protein function;protein structure;Proteins;protonation;receptor;Regulation;research and development;Resolution;small molecule;structural biology;Structure;symporter;Technology;technology development;X-Ray Crystallography

PROJECT_TITLE: MEDIC - MicroED Imaging Center - Driving Biomedical Projects (DBPs)


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Prevention;Women's Health Research

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Narrative  Ductal carcinoma in situ (DCIS) is one of the most commonly diagnosed malignancies of the breast and data are lacking with regard to optimal treatment. Consequently, the majority of DCIS are treated in the same manner: i.e. surgery +/- radiation +/- hormonal therapy that results in either over- or under-treatment of many patients. In the current work we will test the hypothesis that histologic or radiologic markers prior to surgery can guide decision support by identifying predicting up-staging and pathological risk scoring following surgical excision.

PI_NAMEs: DAMAGHI, MEHDI ;NIELL, BETHANY LYNN (contact);RAGHUNAND, NATARAJAN

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Acidosis;Adjuvant;Adjuvant Therapy;advanced analytics;Antibodies;Area;arm;Attention;Axilla;Basic Science;Biochemical;Biological Markers;Biopsy;Breast;Breast Carcinogenesis;Breast conservation;breast malignancies;cancer care;Carcinoma;Cells;Clinical;Clinical Pathways;Clinical Trials;cohort;Consent;contrast enhanced;Core Biopsy;Data;deep learning;Diagnosis;Diagnostic;Disease;disease natural history;disorder risk;Duct (organ) structure;Epigenetic Process;Evolution;Excision;Excision biopsy;Formalin;Foundations;Functional disorder;Genotype;Goals;Habitats;Health;Heritability;Histologic;hormone therapy;Hyperplasia;Hypoxia;Image;Immunohistochemistry;Indolent;Intervention Trial;Knowledge;Lesion;Machine Learning;machine learning model;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Metastatic breast cancer;Methods;Milk;model building;Modeling;Multiparametric Analysis;Mutation;neoplastic;Noninfiltrating Intraductal Carcinoma;Operative Surgical Procedures;optimal treatments;Outcome;Paraffin Embedding;Pathologic;Pathology;Patients;Periodicals;Phenotype;Physiological;Population;practical application;preclinical study;premalignant;Prevalence;Process;prospective;Prospective cohort;Prospective Studies;Proteins;Protocols documentation;Radiation;Radio;Radiology Specialty;radiomics;Receiver Operating Characteristics;Resected;Retrospective cohort;Retrospective Studies;Risk;Sentinel Lymph Node Biopsy;SLC2A1 gene;Staging;Stains;standard of care;statistics;Surgical Pathology;Testing;Time;Tissue Embedding;Tissues;Training;tumor;Validation;validation studies;Variant;Woman;Work

PROJECT_TITLE: Radiomics and Pathomics to predict upstaging of DCIS

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


PROJECT_TERMS: Algorithms;Automobile Driving;Awareness;base;Biological;Books;Collaborations;Communities;community engagement;Community Outreach;Computer software;computerized data processing;Country;Cryoelectron Microscopy;Crystallization;Crystallography;Data;Data Analyses;Data Collection;data sharing;Dedications;Drug Design;drug discovery;Educational workshop;Equipment;experience;experimental study;Future;Goals;Guidelines;imaging facilities;Information Dissemination;Institution;instrument;instrumentation;Internet;Knowledge;Laboratories;Laboratory Research;Learning;Link;member;Methodology;Methods;Micro Electron Diffraction;Negative Staining;Online Systems;operation;outreach;Parents;Participant;practice setting;Preparation;programs;protocol development;Protocols documentation;Publications;Recommendation;Research;Research Activity;research and development;Research Design;Research Methodology;Research Personnel;Resources;Roentgen Rays;Sampling;Scientist;Services;Site;Site Visit;Structure;symposium;System;Techniques;Technology;technology development;technology research and development;Titan;Training;Travel;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: MEDIC - MicroED Imaging Center - Community Engagement


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: PROJECT NARRATIVE The work in these studies will generate fundamental knowledge of the molecular mechanisms underlying the protein-protein interactions of the APP ectodomain and the cellular consequences of these interactions across different cell types. These studies have the potential to lay the foundation for future work to harness the fundamental functions of APP to counteract pathogenic pathways in Alzheimer’s disease, Down syndrome, and obesity.

PI_NAMEs: RICE, HEATHER C. (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Address;Affinity;Alzheimer's Disease;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Binding;Cell Membrane Proteins;Cell Physiology;Cell Surface Proteins;cell type;cognitive function;design;Disease;Down's Syndrome;Etiology;Extracellular Domain;Family member;Foundations;Future;GABA-B Receptor;gamma-Aminobutyric Acid;Generations;Goals;Health;Knowledge;Lead;Length;Ligand Binding;Ligands;Mediating;Membrane Proteins;Mitochondria;Molecular;Neuroglia;novel;Obesity;Pathogenicity;Pathway interactions;Phosphoglycerate Mutase;Phosphorylation;Physiological;Protein Fragment;protein function;protein protein interaction;Protein Serine/Threonine Phosphatase;Proteolytic Processing;receptor;Receptor Signaling;Regulation;Research;response;Signal Pathway;Signal Transduction;Work

PROJECT_TITLE: Mechanisms of APP ectodomain function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ORG_CITY: SAN DIEGO

ORG_DEPT: CHEMISTRY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Project Narrative  High-throughput screening of compound libraries is a fundamental starting point to drug development efforts, and natural product libraries are one of the most valuable sources of novel bioactive molecules. However, until now there have been few evidence-based rules for the rational design of natural product libraries. This work is relevant to public health because it will demonstrate the utility of bioanalytical liquid chromatography-mass spectrometry to addressing this biological need, and lead to accelerated drug development in the long term.

PI_NAMEs: CICHEWICZ, ROBERT HENRY;MCCALL, LAURA-ISOBEL  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Acceleration;Accounting;Address;Affect;Alternaria;American;Biological;Breathing;Chemicals;citizen science;clinical translation;Coculture Techniques;Collection;Complex;cost;Data;design;Disease;Diversity Library;drug development;drug discovery;drug resource;emerging pathogen;Ensure;Environment;Epidemic;evidence base;fungus;Generations;Habits;high throughput screening;Individual;Lead;Libraries;Liquid Chromatography;liquid chromatography mass spectrometry;metabolomics;Methodology;Methods;microbial;Natural product discovery;Natural Products;Nature;novel;novel strategies;Oklahoma;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Poverty;Production;programs;Public Health;quorum sensing;Randomized;Rare Diseases;rational design;Reporting;Risk;Running;Sampling;scaffold;Signal Transduction;single molecule;small molecule;small molecule libraries;Soil;Source;Stress;success;System;tandem mass spectrometry;Testing;Trichoderma;Universities;Validation;Work

PROJECT_TITLE: An LCMS-guided bioanalytical approach for rational natural product library design and optimization

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]