NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Contraception/Reproduction;Dementia;Hypertension;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Neurodegenerative;Neurosciences;Pregnancy;Prevention;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_DEPT: FAMILY MEDICINE

PHR: PROJECT NARRATIVE Women have a two-fold higher lifetime risk for Alzheimer Disease (AD), vascular dementia, and related dementias (RD) compared to men. Hypertensive disorders of pregnancy, including preeclampsia, eclampsia, and gestational hypertension, may contribute to sex differences in ADRD, with midlife experiences such as depression influencing the magnitude of risk. We propose to 1) create a model that can identify AD and related dementias in a large health administrative database; and 2) test the link (and mediating factors) between hypertensive disorders of pregnancy and ADRD, which will serve as the first step towards creating women’s tailored intervention that can mitigate ADRD risk for women.

PI_NAMEs: SCHLIEP, KAREN C. (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: administrative database;Affect;Age;Aging;aging population;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Applications Grants;Area;Award;biomedical informatics;Blood Vessels;career;Chronic Disease;Classification;Clinical;clinical diagnostics;Cognitive;cohort;Cohort Studies;comorbidity;cost;County;Data;Data Analyses;Data Set;Databases;Dementia;dementia risk;Diagnosis;Disparity;Disproportionately impacts women;Eclampsia;Elderly;Epidemiology;epidemiology study;Etiology;experience;Family;Fertility;Fostering;Frontotemporal Dementia;Future;Genetic;Goals;Health;health assessment;health difference;Health Status;high risk;Hypertension;hypertension treatment;hypertensive;Image;improved;improved outcome;Individual;Inflammatory;International;Intervention;Knowledge;late life;Lead;Lewy Body Dementia;Life course epidemiology;Life Cycle Stages;life span;lifetime risk;Link;Longevity;longitudinal analysis;Machine Learning;machine learning model;Maternal-fetal medicine;Mediating;Medical;Medical Records;Memory;men;Menopause;Mental Depression;Mentored Research Scientist Development Award;Mentors;Methods;middle age;Midlife women;Modeling;mortality risk;Neurologic;Neurological outcome;Neurologist;Neuropsychology;normotensive;novel;Outcome;Patients;Population;population based;Population Database;Population Research;Population Study;Positioning Attribute;Pre-Eclampsia;predictive modeling;Pregnancy;Pregnancy Complications;pregnancy disorder;pregnancy hypertension;Prevalence;prevent;Principal Investigator;professor;programs;prospective;Psychosocial Factor;Public Health;Recording of previous events;Records;reproductive;Reproductive Health;reproductive system disorder;Research;Research Methodology;Research Personnel;Retrospective cohort study;Retrospective Studies;Risk;Risk Factors;risk mitigation;Sensitivity and Specificity;sex;Sex Differences;skills;Social Environment;sociodemographics;Testing;Training;Universities;Utah;Validation;Vascular Dementia;Woman;women versus men;Women's Health;women's reproductive health

PROJECT_TITLE: Hypertensive Disorders of Pregnancy and Subsequent Risk of Vascular Dementia, Alzheimer's Disease, or Related Dementia: A Retrospective Cohort Study Taking into Account Mid-Life Mediating Factors.

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ADMINISTERING_IC: EB

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE To preserve their vision, glaucoma patients must take daily eye drop medications; and yet, 40% of patients do not do this, and 20% are unable to successfully instill the drops into their eyes. We will quantify and understand the movement factors influencing eye drop instillation success and use this information to inform the development of a scalable Eye Drop Adherence Monitoring System that measures each time eye drops are dispensed and whether the drops are successfully instilled into the eye. Accurate monitoring of eye drop adherence is an essential step towards providing effective support for people to self-manage their glaucoma.

PI_NAMEs: CAIN, STEPHEN MATTHEW;NEWMAN-CASEY, PAULA ANNE (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, KRISTIN HEDGEPATH

PROJECT_TERMS: acceptability and feasibility;Adherence;Adult;Affect;African American;African American population;Age;Aging;aging related;Agreement;Algorithms;American;base;Behavior;Biomechanics;Blindness;body position;Caring;Cellular Phone;Classification;Clinical;Communication;Computers;Controlled Environment;Data;data communication;design;Development;Diagnosis;diaries;Discrimination;Drops;Educational process of instructing;effective therapy;Effectiveness;Engineering;ethnic minority;Event;Eye;Eyedrops;Feedback;Glaucoma;Goals;Hand functions;Head;Home;Impairment;improved;Individual;Intervention;Interview;intrinsic motivation;Knowledge;Limb structure;Link;low socioeconomic status;Machine Learning;Measures;Medical Care Team;medication compliance;microsensor;Monitor;motion sensor;Movement;novel;older adult;outcome disparities;Participant;patient oriented;Patients;performance tests;personalized intervention;Persons;Pharmaceutical Preparations;Physicians;Population;portability;Positioning Attribute;Posture;power consumption;Predictive Factor;preservation;prevent;Probability;programs;Proprioception;prototype;Provider;racial minority;Research;Sampling;Schedule;Self Management;sensor;sensor technology;success;System;Tactile;Testing;Text;Text Messaging;text messaging intervention;Time;tool;United States;usability;user centered design;user-friendly;Video Recording;Vision;wearable sensor technology;Work

PROJECT_TITLE: Quantifying and Understanding Glaucoma Eye Drop Medication Instillation and Adherence

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Pediatric;Precision Medicine

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Diagnostic assessment of autism spectrum disorder (ASD) has benefitted from the development of standardized assessment tools. However, recent research indicates that the diagnostic validity of commonly used instruments varies substantially as a function of child characteristics (e.g., biological sex, language level, cognitive ability, behavior problems). Leveraging information from assessments of more than 17,500 children, the proposed study will determine how to optimize use of standardized instruments, alone or in combination, for determining ASD diagnosis in specific subgroups of children for clinical or research purposes.

PI_NAMEs: BISHOP, SOMER L. (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Affect;Age;artificial neural network;Assessment tool;Attention deficit hyperactivity disorder;Autism Diagnosis;Autism diagnostic;autism diagnostic observation schedule;autism spectrum disorder;autism symptoms;autistic children;Behavioral;behavioral phenotyping;biological sex;Case Study;Characteristics;Child;Child Behavior Checklist;Classification;Clinical;clinical diagnosis;clinically significant;cognitive ability;comorbidity;Data;Data Analyses;Decision Making;Decision Trees;Development;Developmental Delay Disorders;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic platform;diagnostic tool;Education;Electronics;ethnic minority;Evaluation;Explosion;Female;girls;Goals;Guidelines;Health;Heterogeneity;improved;Individual;individual variation;Infant;instrument;Intellectual functioning disability;Interview;Knowledge;Language;Language Disorders;Light;Literature;Machine Learning;Male Adolescents;Measures;Methods;Modified Checklist for Autism in Toddlers;next generation;Paper;Parents;Participant;Performance;personalized approach;Persons;Phenotype;phrases;Population;Population Characteristics;Predictive Value;prevent;Problem behavior;Procedures;Process;Property;Psychometrics;Questionnaires;racial minority;Recommendation;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resources;Risk;Sampling;screening;Screening procedure;Sensitivity and Specificity;Services;sex;skills;social;social communication;Specific qualifier value;Speech;Standardization;Stretching;study characteristics;Subgroup;System;Techniques;Testing;Time;Toddler;tool;Triage;Update;Validation;verbal;Weight;Work;Youth

PROJECT_TITLE: Individualized approaches to determining likelihood of ASD caseness

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: RICHMOND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE  Diabetic retinopathy (DR) is the most common cause of severe vision loss in the working-age population in the world, and the standard drug treatment is the intravitreal (IVT) injection of anti-VEGF agents that must be frequently administered and are not adequately responded by 40% DR patients. Oral administration of fenofibrate, a PPARα agonist, has shown robust therapeutic effects on DR in type 2 diabetic patients; however oral fenofibrate has poor retinal absorption and IVT injection of fenofibrate is short-lived, requiring frequent IVT injections. Here, we propose a new method to provide sustained delivery of fenofibrate to effectively and safely treat DR with 2 or less IVT injections/year, significantly reducing the treatment burden of diabetic patients.

PI_NAMEs: MA, JIAN-XING ;XU, QINGGUO  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: absorption;Acute;Address;Age;Agonist;angiogenesis;Animal Model;Animals;Blindness;Blood Vessels;Bolus Infusion;Chronic;Chronic Disease;Clinical;clinical practice;Clinical Research;clinical translation;Clinical Treatment;Clinical Trials;cost;Data;db/db mouse;Development;diabetic;diabetic patient;diabetic rat;Diabetic Retinopathy;Dose;Drug Delivery Systems;Drug Kinetics;drug standard;Drug Targeting;Dyslipidemias;efficacy testing;Endophthalmitis;Extravasation;Eye;Fenofibrate;Formulation;Future;Genes;Half-Life;Healthcare Systems;Human;improved;In Vitro;in vivo;Inflammation;inhibitor;Injections;Insulin-Dependent Diabetes Mellitus;Intercellular adhesion molecule 1;interest;Interleukin-6;intravitreal injection;Ischemia;Kidney Failure;Knock-out;Lead;Leukostasis;lipid metabolism;Lipids;macular edema;Maximum Tolerated Dose;Medical;meter;Methods;Mitochondria;Modeling;Monitor;Morphology;nanoparticle;neovascularization;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Oral;Oral Administration;Oryctolagus cuniculus;oxidation;particle;Particle Size;Pathway interactions;Patient Care;Patient Compliance;Patients;Pharmaceutical Preparations;Pharmacotherapy;Population;PPAR alpha;preclinical development;Prevention;proliferative diabetic retinopathy;randomized placebo-controlled clinical trial;Rattus;Regulation;Reporting;Reproducibility;Retina;Retinal Neovascularization;retinal toxicity;Risk;Safety;safety study;side effect;Streptozocin;Testing;Therapeutic Effect;Toxic effect;Treatment Efficacy;Type 2 diabetic;Vascular Endothelial Growth Factors;Virulence Factors;Vision

PROJECT_TITLE: Sustained release of fenofibrate for the treatment of diabetic retinopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: BETHLEHEM

ORG_DEPT: BIOLOGY

ORG_NAME: LEHIGH UNIVERSITY

ORG_STATE: PA

PHR: Narrative During slow-wave of sleep and absence epilepsy, the brain is unresponsive to sensory input; the thalamic reticular nucleus is thought to focus this neural “searchlight” of arising sensory attention. Here, we will leverage optogenetic and photostimulation techniques to determine the specific functional topography of electrically coupled networks, which form the dominant synaptic connection within TRN. The method established here can be applied to easily and quickly map coupled interneuron networks throughout the brain.

PI_NAMEs: HAAS, JULIE S (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Absence Epilepsy;Acute;Area;Attention;Attention deficit hyperactivity disorder;Binding;Brain;Brain region;Cell Nucleus;Cells;Communication;Computer Models;connexin 36;Coupled;Coupling;Dependence;design;Discrimination;Disease;Electrical Synapse;Electrophysiology (science);Epilepsy;experience;Gap Junctions;Goals;In Vitro;information processing;insight;Interneurons;Investigation;Lead;Link;Maps;Measures;Mediating;Mental Depression;Methods;Modality;Modeling;Modernization;Molecular;molecular subtypes;Nervous System Disorder;neural;neuronal cell body;Neurons;novel;novel strategies;Opsin;optogenetics;patch clamp;Pathway interactions;Pattern;Phenotype;Physiological;Population;Publishing;Research;Role;Schizophrenia;segregation;Sensory;sensory gating;sensory input;Services;Sleep;sleep epilepsy;Slow-Wave Sleep;Specificity;success;Synapses;synaptic depression;Techniques;Testing;Thalamic structure;Time;transmission process;voltage;Work

PROJECT_TITLE: Identifying Electrically Coupled Networks in vitro

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease;Rare Diseases;Vector-Borne Diseases

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: INFECTIOUS DISEASES INSTITUTE

PHR: PROJECT NARRATIVE Schistosoma mansoni (Sm) and hepatitis B virus (HBV) are endemic infections in Africa with substantial prevalence, morbidity and mortality. Proposed is a clinical and mechanistic investigation to characterize the nature and magnitude of impact from Sm infection on the course of chronic HBV infection. Findings will provide insight for understanding and managing the co-occurring endemics of Sm and HBV in many regions of Africa.

PI_NAMEs: OCAMA, PONSIANO  (contact)

PROGRAM_OFFICER_NAME: FLORESE, RUTH HUAB

PROJECT_TERMS: Address;Africa;Africa South of the Sahara;Biological Assay;Biopsy;Blood;Blood specimen;career development;CD8B1 gene;Cessation of life;Chronic Hepatitis B;chronic liver disease;Clinical;clinical investigation;Clinical Management;co-infection;cohort;Collection;Communicable Diseases;Country;Data;Development;Diagnosis;Diagnostic Procedure;Disease;DNA;Epidemiology;Feces;follow-up;Foundations;Funding;Future;Geography;Grant;Hepatitis B Virus;HIV;Hygiene;Image;Immune;Immune response;Immunologics;Immunology;improved;Incidence;Individual;Infection;infection burden;Infrastructure;insight;Interferon Type II;Investigation;Liver;liver biopsy;Liver Fibrosis;London;Malignant neoplasm of liver;Measures;Medical Research;Microscopy;Morbidity - disease rate;mortality;National Cancer Institute;Natural Killer Cells;Nature;novel;Patients;Pattern;peripheral blood;Persons;Praziquantel;Prevalence;Primary carcinoma of the liver cells;Process;Public Health;Research;Research Infrastructure;Research Institute;Research Personnel;response;Risk;Schistosoma mansoni;Schistosoma mansonii infection;Schistosomiasis;Schools;Serology;Serum;Serum Markers;socioeconomics;Staging;Technology Transfer;treatment response;Tropical Medicine;Uganda;ultrasound;Universities;Urine;Viral;viral DNA;Viral hepatitis;virology;Virus;Virus Diseases;Work

PROJECT_TITLE: Clinical and immunological impact of Schistosoma mansoni infection and treatment on the course of chronic hepatitis B virus (HBV) infection in Uganda

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(55)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Mental Health;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Programming of child asthma and respiratory health is influenced by maternal exposures such as a woman’s lifetime stress and consequent oxidative stress, an underexplored mechanism of prenatal programming of child respiratory health. This investigation will be the first to examine associations among maternal lifetime psychosocial stress, novel biomarkers of systemic and cumulative oxidative stress, and child asthma and lung function in a racial/ethnically diverse cohort of mother child dyads. The planned approach may allow for detection of relationships that vary across racial/ethnic groups and contribute to novel prevention and treatment strategies.

PI_NAMEs: CARROLL, KECIA NICOLE (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Accounting;Address;Age;Antioxidants;Asthma;Biological;Biological Clocks;Biological Markers;Biological Process;biomarker selection;Black, Indigenous, People of Color;Body mass index;Cells;Child;Childhood Asthma;Chronic stress;cohort;Cohort Studies;Complex Mixtures;Detection;Disease Outcome;disorder risk;Disparity;early childhood;Environmental Risk Factor;Equilibrium;ethnic diversity;Ethnic Origin;Ethnic Population;Event;experience;Exposure to;F2-Isoprostanes;Fetal Diseases;fetal programming;Genome;Growth and Development function;health disparity;heteroplasmy;in utero;indexing;Individual;insight;Interpersonal Violence;Investigation;Isomerism;Joints;Life Cycle Stages;Lipid Peroxidation;Low income;Lung;Maternal Exposure;Maternal-Fetal Exchange;Measures;Mediating;Metabolic;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial dysfunction;Modeling;Modification;Molecular;Mothers;Mutate;novel;novel marker;Obesity;offspring;Overweight;Oxidants;Oxidative Phosphorylation;Oxidative Stress;Pathogenesis;people of color;Placenta;Play;Population;Population Heterogeneity;postnatal;Pregnancy;prenatal;prenatal risk factor;prepregnancy;Prevention strategy;Process;Production;Psychosocial Stress;psychosocial stressors;pulmonary function;Race;racial diversity;racial population;Reactive Oxygen Species;Research;Respiratory Disease;respiratory health;Risk;Role;Sampling;sex;Site;Stress;stressor;Time;Trauma;trauma exposure;treatment strategy;urinary;Wheezing;Woman;Work

PROJECT_TITLE: Associations among maternal lifetime psychosocial stress, prenatal systemic and placental oxidative stress mixtures, and child asthma

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Genetics;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Relevance to public health: Circadian clocks are biological timers that govern physiology and behavior; however, the underlying regulatory mechanisms are not fully understood. Utilizing an integrative approach, the proposed research will reveal novel genetic regulators of circadian rhythms and decipher molecular and physiological mechanisms governing tissue physiology. The fundamental insights will advance our understanding of biological timing and may ultimately lead to novel chronotherapies against clock-related diseases.

PI_NAMEs: YOO, SEUNG-HEE  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: age related neurodegeneration;Behavior;Biochemical;Biological;Biological Clocks;Breeding;Cell Physiology;Cells;Chronotherapy;circadian;circadian pacemaker;Circadian Rhythms;Disease;Dissection;exome sequencing;Foundations;Generations;Genes;Genetic;Genetic Screening;Genetic Transcription;glycogen synthase kinase 3 beta;Goals;Health;Hypothalamic structure;Image;insight;interest;Knowledge;Mammals;Methodology;MicroRNAs;Molecular;mouse genetics;Mus;Muscle function;mutant;Myocardium;novel;Periodicity;Phenotype;Physiological;Physiological Processes;Physiology;Play;Proteins;proteostasis;Public Health;Reagent;Regulation;Reporter;Reporting;Research;Role;Running;Sarcomeres;Scheme;screening;Skeletal Muscle;Striated Muscles;suprachiasmatic nucleus;System;Tissues;ubiquitin-protein ligase;Variant

PROJECT_TITLE: Mammalian circadian rhythms: from genes to mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: WALTHAM

ORG_DEPT: MISCELLANEOUS

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE This study will collect survey, interview, and drug supply data from the community of people who are homeless and who use drugs in the area of Boston known as “Mass and Cass” who have been affected by a recent large- scale street encampment relocation and provided housing equipped with harm reduction services. The study will learn from residents about the impacts of the public health-led relocation and how co-provision of harm reduction services onsite within a housing environment changes drug use, HIV risk behaviors, treatment uptake and the local drug supply.

PI_NAMEs: GREEN, TRACI C (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Abstinence;Acute Hepatitis;addiction;Address;Affect;Air;Area;Behavior;Boston;Caring;Catalogs;Cause of Death;Cities;cohort;Communicable Diseases;Communities;Contracts;COVID-19 pandemic;Crime;Data;Data Set;Disasters;Disease Outbreaks;Drug abuse;drug market;Drug usage;Enrollment;Environment;Epidemiology;Equipment and supply inventories;Evolution;experience;Exposure to;Fentanyl;Gender;Goals;Harm Reduction;Health;health care service;Hepatitis A Virus;HIV;HIV risk;Homeless persons;Homelessness;Hospitals;Housing;Illicit Drugs;Improve Access;improved outcome;Individual;Injections;insight;Intervention;Interview;Leadership;Learning;Life;Link;Massachusetts;Measurement;Measures;meetings;member;Methods;multidisciplinary;Naloxone;Natural experiment;novel;Outcome;Overdose;overdose risk;Patterns of Care;peer;peer support;Persons;Pharmaceutical Preparations;Policies;Positioning Attribute;pre-exposure prophylaxis;prevention service;Process;programs;Prophylactic treatment;Public Health;public health emergency;Public Housing;Research;Research Support;residence;response;Risk;Risk Behaviors;risk mitigation;Role;Safety;SARS-CoV-2 infection;Science;Seasons;Service provision;service uptake;Services;Site;social;social cohesion;social health determinants;Social isolation;Social outcome;statistics;Sterility;Structure;success;supported housing;Surveys;syndemic;Syringes;Time;transitional housing;United States;uptake;Violence;Work

PROJECT_TITLE: Rapid measurement of novel harm reduction housing on HIV risk, treatment uptake, drug use and supply


ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Genomic analysis of genome-edited cellular therapies is critical to ensure their safety and efficacy. However, current methods for measuring on-target editing efficiency and identifying unwanted somatic mutations use antiquated methods or require modifications to the editing process and so cannot be used to analyze cellular products that will be given to patients. In this application, we propose to optimize our recently described whole- genome sequencing assay for somatic mutations in cancer (ChromoSeq) so that it can be used for rapid, accurate, and comprehensive genomic evaluation of fully manufactured genome-edited cellular therapies.

PI_NAMEs: DUNCAVAGE, ERIC J;SPENCER, DAVID H (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Address;Adverse effects;Alleles;Benchmarking;Binding Sites;Biological Assay;Cancer Patient;Cell Physiology;Cell Therapy;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Chromosomal Rearrangement;Clinical;Clinical Research;Clinical Trials;Collection;cost effective;Coupled;CRISPR/Cas technology;Dangerousness;Data;Data Set;deep sequencing;design;DNA;DNA analysis;DNA sequencing;efficacy evaluation;Ensure;Evaluation;experience;experimental study;Frequencies;Funding;Future;Genes;genome analysis;genome editing;genome sequencing;genome-wide analysis;genomic platform;Genomics;Goals;Guide RNA;Guidelines;Human;Human Cell Line;Human Genome;improved;in silico;insertion/deletion mutation;integration site;Joints;Malignant Neoplasms;manufacture;manufacturing process;Measurement;Measures;Methods;Modification;mutant;Mutation;off-target mutation;Patients;Performance;Pharmaceutical Preparations;Process;Qualifying;Reagent;Recommendation;Safety;Single Nucleotide Polymorphism;somatic cell gene editing;Somatic Mutation;Specificity;targeted nucleases;Technology;Testing;Therapeutic;Transgenes;tumor;United States Food and Drug Administration;Variant;whole genome

PROJECT_TITLE: Genome sequencing for evaluating the efficacy, specificity, and safety of human genome editing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-M(70)R]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Social Determinants of Health;Suicide

ORG_CITY: NORTH CHICAGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI

ORG_STATE: IL

PHR: NARRATIVE  Sexual minority adolescents (SMA) are disproportionately affected by mental health problems (e.g., depression, suicidality) relative to their heterosexual peers, which is generally attributed to unique interpersonal stressors (e.g., sexual orientation-related rejection). In addition to experiences of rejection, rejection sensitivity (RS; i.e., expectations of rejection accompanied by anxiety and/or anger) also plays an important role in mental health, but little is known about its development and role in SMA's mental health. As such, the goals of the proposed R01 are to: (1) Determine the longitudinal and daily relations among sexual orientation-related rejection, RS (anxious and angry), and mental health (depression, suicidal ideation, and reactive aggression); (2) Identify mechanisms (social withdrawal, self- and other-blame in response to rejection, and sexual orientation concealment) underlying the longitudinal and daily relations between RS and mental health problems; and (3) Examine sexual orientation-related social support and acceptance as protective factors in the development of RS.

PI_NAMEs: FEINSTEIN, BRIAN  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Adolescence;adolescent mental health;Adult;Affect;Age;Aggressive behavior;Anger;Anxiety;anxious;Attention;Clinical;cohort;Cross-Sectional Studies;Data;depressive symptoms;Development;Disparity;early experience;Emotions;expectation;experience;Face;Feeling suicidal;Goals;Health;Heterosexuals;improved;Individual;Intervention;Investigation;Lesbian Gay Bisexual;Life;Link;Mental Depression;Mental Health;Methods;Modeling;novel;Participant;peer;Personal Satisfaction;Play;Population;protective factors;Public Health;Reaction;recruit;Reduce health disparities;Reporting;Research;response;Risk Factors;Role;Sampling;Sampling Studies;Sex Orientation;Sexual and Gender Minorities;sexual minority;sexual minority group;sexual minority youth;sexual role;social;Social support;Strategic Planning;stressor;suicidal;Testing;theories;Time;United States National Institutes of Health;Withdrawal;Work

PROJECT_TITLE: A longitudinal and experience sampling investigation of rejection sensitivity and its role in sexual minority adolescents' mental health

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: NARRATIVE Targeting RNA Splicing in Glioma  RNA alternative splicing (AS) is an evolutionally conserved co-transcriptional process. AS regulates landscapes of transcriptomes and proteomes in development and diseases such as cancer. This application will investigate the relationship between glioma driver mutations and tumor-associated AS programs that affect glioma malignancy, and test whether targeting RNA splicing constitutes a therapeutic vulnerability to treat gliomas.

PI_NAMEs: CHENG, SHI-YUAN  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;Affect;Alternative Splicing;Antisense Oligonucleotides;avatar models;Biological;Biological Models;Biological Process;CDKN2A gene;Cell model;Classification;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Data Set;Development;differential expression;Disease;DNA Sequence Alteration;driver mutation;Duchenne muscular dystrophy;epidermal growth factor receptor VIII;Eukaryota;Event;Evolution;Genome;Genotype;Glioma;Goals;Growth;human disease;Human Engineering;human induced pluripotent stem cells;innovation;Knowledge;Maintenance;Malignant Neoplasms;malignant phenotype;Mediating;Mediator;methylome;Modeling;Molecular;molecular subtypes;Mutation;novel;Oligonucleotides;Oncogenic;Pathway interactions;patient prognosis;Patients;Phenotype;Prognosis;programs;Property;Protein Binding Domain;protein expression;Protein Isoforms;Protein Splicing;Proteins;Proteome;PTEN gene;Research;Research Project Grants;RNA Splicing;RNA-Binding Proteins;Spliced Genes;stem-like cell;Technology;Testing;Therapeutic;Therapeutic Intervention;Transcription Process;transcriptome;transcriptome sequencing;treatment response;tumor;Tumor Biology;tumor xenograft;Tumorigenicity;Xenograft Model

PROJECT_TITLE: Targeting RNA Splicing in Glioma

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Nutrition;Organ Transplantation;Transplantation

PHR: PROJECT NARRATIVE The number of people in need of a liver transplant far exceeds the number of suitable donor livers, yet every year a substantial proportion of donated livers are discarded because they contain too much fat. Livers that contain too much fat are more susceptible to transplant-related ischemia reperfusion injury (IRI) resulting in poorly functioning grafts, a process that is neither preventable nor easily reversed. The proposed research will offer key insights into how lipid metabolism and composition participate in hepatic IRI, with the goal of identifying novel therapeutic approaches to attenuate or prevent IRI, ultimately increasing organ availability and improving recipient outcomes.

PI_NAMEs: LISS, KIM HUNG HO (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Anti-Inflammatory Agents;Attenuated;Award;Benign;Bioinformatics;Biological Markers;Bone Marrow;career;career development;Caring;Cell Death;cell injury;Chemicals;Chemistry;Childhood;Coculture Techniques;Communities;cytotoxic;Data;Development Plans;Developmental Biology;drug development;Drug Targeting;Environment;Experimental Models;Extrahepatic;Fatty acid glycerol esters;Fatty Acids;Fatty Liver;Fellowship;Fibrosis;Functional disorder;Funding;Gastroenterology;Genomics;Goals;graft function;Hepatic;Hepatic Tissue;Hepatocyte;Hepatology;High Fat Diet;Homeostasis;Hydrolysis;Hypoxia;Immunology;improved;In Vitro;Incubators;Infiltration;Inflammation;Inflammatory;Inflammatory Infiltrate;inhibitor;Injury;insight;interest;Intervention;intrahepatic;knock-down;Knock-out;Knowledge;Knowledge acquisition;Kupffer Cells;Laboratories;Learning;Lecithin;Lipase;lipid metabolism;Lipid Synthesis Pathway;lipidome;lipidomics;Lipids;Lipolysis;Liver;Liver Failure;liver injury;liver ischemia;liver transplantation;Macrophage;Mediating;Mediator;medical schools;Medicine;Mentors;Metabolic Pathway;Metabolism;metabolomics;mortality;multiple omics;Mus;Natural regeneration;non-alcoholic fatty liver disease;Nonesterified Fatty Acids;novel;novel therapeutic intervention;nutrition;Operative Surgical Procedures;Organ;Organ Donations;Organ Donor;Outcome;Patient-Focused Outcomes;Pediatrics;Persons;Phenotype;Phospholipids;Physicians;Plasma;Predisposition;Prevalence;prevent;Process;Recording of previous events;Recovery;recruit;Reperfusion Injury;Reperfusion Therapy;Research;Research Personnel;Research Training;Resources;response;Role;Scientist;Secondary to;single nucleus RNA-sequencing;skills;Structure;Technical Expertise;Testing;theories;Therapeutic Intervention;tissue repair;Training;transcriptome sequencing;Transplantation;Triglycerides;United States National Institutes of Health;Universities;Waiting Lists;Washington;Wild Type Mouse;Work

PROJECT_TITLE: Role of Lipid Metabolism in Hepatic Ischemia Reperfusion Injury in Steatotic Livers

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Lung;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Successful completion of the proposed studies will reveal a novel role of HDAC6 in the pathogenesis of silicosis. The studies will validate the therapeutic potential of HDAC6 inhibition against silicosis. The proposed studies will provide important information for future clinical trials.

PI_NAMEs: FU, JIAN  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Acetylation;AKT1 gene;alpha Tubulin;Alveolar Macrophages;Alveolus;Autoimmune Diseases;Binding;Cell Physiology;Chronic;Clinical Trials;Cytoplasm;Deacetylase;Deacetylation;Deposition;Diagnosis;Disease;Dust;effective therapy;Exposure to;Fibrosis;Functional disorder;Future;Genetic Transcription;HDAC6 gene;Inflammation;Inflammatory;Inflammatory Response;Ingestion;Inhalation;Injury;Leukocytes;Malignant Neoplasms;Mediating;Mediator;Microtubule Stabilization;Microtubules;Molecular;mouse model;Myelogenous;novel;Nuclear Translocation;particle;Pathogenesis;Patients;Persons;Phenotype;Phosphorylation;Play;Production;Profibrotic signal;protective effect;protein function;Pulmonary Fibrosis;Pulmonary Inflammation;Regulation;Reporting;response;Risk;Role;Signal Transduction;Silicon Dioxide;Silicosis;Testing;Therapeutic;therapeutic target;TNF gene;transcriptomics;Transforming Growth Factor beta;Tubulin;Work

PROJECT_TITLE: Inflammatory Injury Caused by Silica Exposure

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: This project will test the novel hypothesis that noninvasive vagus nerve stimulation will result in the improvement of vascular inflammation and oxidative stress in African Americans.

PI_NAMEs: SHIBAO, CYNDYA ADRIANA (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: 3-nitrotyrosine;Academia;Academic Medical Centers;Acetylcholinesterase;Acetylcholinesterase Inhibitors;Acute;adduct;African American population;Animal Model;Antigen-Presenting Cells;Aorta;Area;Atherosclerosis;Award;bioelectronics;Blinded;Blood Vessels;Cardiovascular Diseases;career;Cause of Death;cholinergic;Chronic;Clinical Pharmacology;Collaborations;Credentialing;cytokine;Dedications;Development;Ear lobe;effective therapy;Endothelial Cells;endothelial dysfunction;Endothelium;Enrollment;Event;experience;Faculty;Foundations;Functional disorder;Funding;Galantamine;Harvest;Hispanic Populations;Hypertension;immune activation;immunogenic;Impairment;improved;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Infusion procedures;Intercellular adhesion molecule 1;Intervention;Leadership;Link;Lipids;Measures;Mediating;Medicine;member;Mentors;mid-career faculty;monocyte;Morbidity - disease rate;mortality;NADP;NADPH Oxidase;neuroregulation;Nitric Oxide;Nitric Oxide Signaling Pathway;novel;novel strategies;Outcome;oxidation;Oxidative Stress;Parasympathetic Nervous System;Parents;Participant;patient oriented;Peripheral Blood Mononuclear Cell;Population;Postdoctoral Fellow;prevent;Production;Proteins;Publications;randomized placebo controlled study;Reactive Oxygen Species;Regulation;Research;Research Personnel;Research Project Grants;Research Training;response;Signal Pathway;skills;Source;Strategic Planning;Superoxides;Testing;Time;Tragus;Training;training opportunity;transmission process;vagus nerve stimulation;vascular endothelial dysfunction;vascular inflammation;Work

PROJECT_TITLE: Mentoring in cholinergic regulation of vascular oxidation

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Aging;Diabetes;Genetics;Human Genome

ORG_CITY: BOSTON

ORG_NAME: JOSLIN DIABETES CENTER

PHR: PROJECT NARRATIVE  Diabetes is a critical health problem in the US because it leads to fatal complications. These studies will determine the mechanisms contributing to age-associated β-cell functional decline. Understanding how mRNA chemical modifications regulate gene expression will facilitate development of therapeutic strategies.

PI_NAMEs: F DE JESUS, DARIO  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Acceleration;Adult;Age;age related;aged;Aging;Area;ATM activation;Autoimmune;Automobile Driving;Beta Cell;beta-Galactosidase;Bioinformatics;Biology of Aging;Candidate Disease Gene;candidate validation;career;Cell Aging;Cell Line;Cell Physiology;Cell secretion;Cell Survival;Chemicals;comparison control;Complement;crosslink;crosslinking and immunoprecipitation sequencing;Data;Data Analyses;Data Set;Dependovirus;Development;Diabetes Mellitus;Disease;DNA Damage;Exhibits;experience;experimental study;Female;Foundations;functional decline;Future;Gene Expression;Genes;Genetic Models;Goals;hallmarks of aging;Health;High Fat Diet;Homologous Gene;Human;Immunoprecipitation;Impairment;improved;in vivo;in vivo evaluation;Inbred NOD Mice;Inflammation;insight;Insulin Resistance;islet;Knockout Mice;Messenger RNA;Metabolism;Methods;Methylation;methylome;Methyltransferase;Modification;Molecular;Molecular Biology;Molecular Target;mouse genetics;mRNA Translation;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Pathway interactions;Patients;Phase;Physiology;protein complex;Publishing;Regulation;Research;Research Personnel;response;Ribonucleosides;RNA;RNA Splicing;Role;senescence;single-cell RNA sequencing;stressor;Testing;therapeutic development;therapeutic target;Time;Training;Transcript;transcriptomics;type I and type II diabetes;Up-Regulation;Work

PROJECT_TITLE: Interrogating the role of m6A mRNA methylation in the aging of the β-cell and diabetes

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: Columbus

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Several electrogenic proteins critical for electrical excitation in cardiac tissue (including voltage-gated sodium channels, inward-rectifying potassium channels, L-type calcium channels, the sodium- potassium ATPase, and the sodium-calcium exchanger) reside in distinct ion channel “pools” within cells, with a subset of these channels critical for conduction preferentially localized at the site of cell- cell junctions, the intercalated disk. While recent evidence suggests that cardiac conduction is sensitive to perturbations at the intercalated disk, the contributions of these distinct ion channel pools and the intercalated disk nanoscale structure in regulating conduction under both normal and pathological conditions are not fully understood. We hypothesize that distinct ion channel pools on the lateral membrane and both at and within the intercalated disk, and intercalated disk structure constitute the key components of a “global/local control” system that regulate robust cardiac conduction, mitigating sensitivity to changes in ion channel and gap junction expression, and that this system of regulation is disrupted during pathological settings, including non-ischemic heart failure.

PI_NAMEs: HUND, THOMAS JEFFREY;VEERARAGHAVAN, RENGASAYEE ;WEINBERG, SETH HOWARD (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Ablation;Acute;Adhesions;Angiotensin II;Anti-Arrhythmia Agents;Arrhythmia;Calcium Channel;Cardiac;Cells;Chronic;Closure by clamp;Complex;Computer Analysis;Computer Models;Connexin 43;Connexins;Coupling;Data;data pipeline;Defect;diagnostic value;Disease;Disease Progression;Electric Stimulation;Electron Microscopy;Electrophysiology (science);Elements;Experimental Models;experimental study;Formulation;Gap Junctions;Genetic;Health;Heart;Heart failure;Heterogeneity;Human;inhibitor;Intercalated disc;Intercellular Junctions;interstitial;inward rectifier potassium channel;Ion Channel;L-Type Calcium Channels;Lateral;light microscopy;Link;Maps;Measurement;Measures;Mechanics;Mediating;Membrane;Microscopy;Modeling;Molecular;Mus;Mutation;Myocardium;Na(+)-K(+)-Exchanging ATPase;nano;nanoscale;neglect;novel;novel therapeutic intervention;Optics;Pathologic;Pathology;Patients;Peptides;pharmacologic;plakoglobin;Predisposition;preservation;Proteins;Regulation;Research;response;Risk;simulation;Site;Sodium Channel;Sodium-Calcium Exchanger;Structural defect;Structure;Structure-Activity Relationship;System;TAC1 gene;targeted treatment;Techniques;Testing;Tissue Model;Tissues;ultra high resolution;Validation;Ventricular;voltage;Work

PROJECT_TITLE: Distinct Ion Channel Pools and Intercalated Disk Nanoscale Structure Regulate Cardiac Conduction

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative The proposed work will significantly advance our understanding of the post-embryonic cellular mechanisms underlying cognitive dimensions in genetically identifiable cases of mental illness. This knowledge will provide a solid mechanistic basis for the design of novel therapeutic options to treat cognitive deficits.

PI_NAMEs: HIROI, NOBORU  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: 22q11.2;Address;Adult;Affect;Animals;Axon;Birth;Brain region;Capital;Cell Physiology;Cells;Childhood;Cognition;Cognitive;Cognitive deficits;cognitive development;cognitive function;cognitive task;Copy Number Polymorphism;Data;design;Development;Diffusion Magnetic Resonance Imaging;Dimensions;Disabling;Disease;Dose;Electron Microscopy;Electrophysiology (science);Event;Exhibits;Fiber;fimbria;flexibility;Funding;Gene Mutation;Genes;Genetic;genetic variant;Goals;granule cell;Heterozygote;high risk;Hippocampus;Human;Impaired cognition;Impairment;improved;In Vitro;in vivo;Individual;Knowledge;Letters;Link;Magnetic Resonance Imaging;memory acquisition;Memory impairment;Mental disorders;migration;Molecular;mouse model;Mus;Mutant Strains Mice;Mutation;Myelin;myelination;Nature;Neonatal;nerve stem cell;Neurodevelopmental Disorder;neurogenesis;Neurons;Nomenclature;novel;novel therapeutics;oligodendrocyte progenitor;Oligodendroglia;Outcome;Pathway interactions;Pharmaceutical Preparations;Physiological;Play;Postembryonic;postnatal;postnatal period;precursor cell;Production;Progress Reports;Proteins;Publishing;Research;Rodent;Role;Short-Term Memory;Signal Transduction;social deficits;Social Interaction;Solid;spatial memory;Speed;stem cells;subventricular zone;Testing;Text;Therapeutic;therapeutic development;Variant;white matter;Wild Type Mouse;Work

PROJECT_TITLE: Postnatal mechanisms of cognitive development in mice

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: Los Angeles

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Narration Human skin exhibits regional specificities. In future regenerative medicine, we need to learn more about how skin regional specificity is set up so we can guide skin stem cells to form proper functional forms. Chickens display high skin regional specificity and serves as an experimental model to decipher these principles.

PI_NAMEs: CHUONG, CHENG-MING  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: 3-Dimensional;Affect;Alopecia;antagonist;Anterior;appendage;Architecture;ATAC-seq;Birds;Cell Communication;Cells;Chickens;ChIP-seq;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Color;combinatorial;Communication;Competence;craniofacial;Data;Dermal;Dermis;Development;Dorsal;Ear;Epidermis;Epigenetic Process;epigenetic regulation;Epithelium;Evaluation;Exhibits;Experimental Models;experimental study;Face;Feathers;Fibroblast Growth Factor;Fibroblasts;Future;Gene Cluster;Gene Expression Regulation;genetic analysis;Genetic Recombination;Genetic study;Genome;genome-wide;Hair;Human;insight;Knowledge;Learning;Mediating;member;Mesenchymal;Modeling;Molecular;molecular scale;Morphogenesis;morphogens;Morphology;Mus;Narration;Neural Crest;Organizational Change;Organoids;Patients;Phenotype;Pluripotent Stem Cells;Polishes;Production;progenitor;Regenerative Medicine;Regulation;Research;Role;Scalp structure;Signal Transduction;single cell analysis;Skin;Skin injury;skin regeneration;Skin Substitutes;Specific qualifier value;Specificity;Specimen;stem cell biology;stem cells;Tail;Technology;Time;Tissue Transplantation;transcriptome;transcriptome sequencing;Transplantation;Untranslated RNA;Variant;Viral;Work

PROJECT_TITLE: Epigenetic Regulation of Skin Regional Specificity

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative The metabolic activity of tumors and the structure and composition of their surrounding microenvironment are crucial, poorly understood components of cancer progression. By developing whole cell spatially-resolved models of tumor metabolism we will test our capacity to faithfully simulate metabolic growth and activity in different settings. In the longer term, we envisage that our computational approach will enable forecast of patient- and site-specific tumor growth and progression, and facilitate the screening of therapeutic interventions.

PI_NAMEs: DUKOVSKI, ILIJA ;KOROLEV, KIRILL SERGEEVICH;SEGRE, DANIEL  (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: 3-Dimensional;Address;Affect;Amino Acids;Area;Biochemistry;Biomass;biophysical model;Biophysics;Cancer cell line;Cancer Model;cell type;Cells;Cellular Metabolic Process;Characteristics;combinatorial;Complex;complex data;computational platform;Computer software;Data;Data Set;Databases;Development;Differential Equation;Dimensions;Ecosystem;Environment;Equilibrium;follow-up;Future;Gene Expression;Genes;genome-wide;Geometry;Glucose;Growth;Heterogeneity;Human;human model;Image;in silico;in vivo;Knowledge;Malignant Neoplasms;mathematical model;Metabolic;metabolic phenotype;Metabolism;microbial;microbiome;Modeling;models and simulation;Morphology;Neoplasm Metastasis;open source;Outcome;Patients;Play;Population;Predictive Cancer Model;Research;Role;screening;Severities;simulation;Site;spatiotemporal;Structure;Surface;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;tool;Translating;tumor;tumor growth;tumor heterogeneity;tumor metabolism;tumor progression;uptake;Vascularization;Warburg Effect;Work

PROJECT_TITLE: Spatio-temporal mechanistic modeling of whole-cell tumor metabolism


ORG_CITY: COLUMBIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: NARRATIVE Erectile dysfunction due to diabetes mellitus is difficult to treat despite advances in pharmacotherapeutic approaches in the field. This unmet need is the focus of this project that has identified a new ion channel in the cell membrane of smooth muscle that contributes to constriction of the penile vasculature.

PI_NAMEs: LAMB, FRED S;WEBB, R CLINTON (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Acute;Address;Affect;Agonist;Angiotensin II;Animal Model;Anions;antagonist;Apoptosis;Arteries;Binding Proteins;biophysical properties;Blood;Blood Vessels;Carbenoxolone;Cardiovascular Diseases;Cell membrane;Cell Volumes;channel blockers;Chronic;Complications of Diabetes Mellitus;constriction;Contracts;Cyclic GMP;Cytoplasm;Data;db/db mouse;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Dilator;Disease;Down-Regulation;Endothelium;Erectile dysfunction;Etiology;extracellular;Family Planning;Generations;Genes;Guanosine Triphosphate;Hydrogen Peroxide;Hyperglycemia;Hyperlipidemia;Impairment;improved;In Vitro;in vitro activity;in vivo;Incidence;Inflammation;Inflammatory;Inflammatory Response;inhibitor;inorganic phosphate;Ion Channel;Knock-out;Knockout Mice;Leucine-Rich Repeat;Life;male;Measures;Mediating;men;migration;montelukast;Mus;MYLK gene;NADP;Nicotinamide adenine dinucleotide;Nitric Oxide;Nitrogen;novel;novel therapeutic intervention;novel therapeutics;Oxidases;Oxidative Stress;Oxides;Oxygen;Pathway interactions;penis;Peroxonitrite;Pharmaceutical Preparations;pharmacologic;phosphodiesterase V;Principal Investigator;Production;Proliferating;Protein Family;Protein Isoforms;Quality of life;Reactive Oxygen Species;receptor;Refractory;Relaxation;Rho-associated kinase;Role;Severities;Sexual Dysfunction;Signal Pathway;Signal Transduction;sildenafil;Smooth Muscle;Smooth Muscle Myocytes;Source;Superoxides;Tamoxifen;Testing;Therapeutic Agents;TNF gene;Vascular Smooth Muscle;Vasodilation;Work

PROJECT_TITLE: LRRC8 anion channels, superoxide and RhoA in diabetic erectile dysfunction

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ORG_CITY: PITTSBURGH

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Title: Structural and functional analysis of a novel class of androgen receptor antagonists Castration-resistant prostate cancer (CRPC) is currently incurable and is the second leading cause of cancer death in American men. Androgen-independent activation of the androgen receptor (AR) remains the major driving force leading to CRPC. Structural and functional analysis of a novel class of AR antagonists capable of inducing AR degradation in the nucleus may lead to new therapeutics for CRPC.

PI_NAMEs: WANG, ZHOU  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: abiraterone;American;analog;Androgen Antagonists;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgen Response Element;Androgens;antagonist;aqueous;Binding;Biological Assay;Cancer Etiology;Cancer Patient;Castration;Cell Nucleus;Cells;Cessation of life;Chemicals;chromatin immunoprecipitation;Complex;course development;Cryoelectron Microscopy;Data;design;detection assay;Development;dosage;driving force;drug development;DU145;enzalutamide;FDA approved;Generations;Genes;Goals;improved;In Vitro;inhibitor;Lead;Length;Libraries;Ligand Binding Domain;Malignant neoplasm of prostate;Medicine;men;Metastatic Prostate Cancer;Methodology;Methods;Modeling;mRNA Expression;next generation;novel;novel strategies;novel therapeutics;Nuclear;Parents;particle;Patients;PC3 cell line;Proliferating;prostate cancer cell;prostate cancer cell line;Prostate Cancer therapy;Receptor Activation;receptor binding;Relapse;Resistance;Resistance development;RNA Splicing;Ru-1881;scaffold;small molecule;Solubility;Specificity;Stanolone;Structure-Activity Relationship;success;Surface Plasmon Resonance;targeted agent;targeted treatment;Testing;tumor growth;tumor xenograft;Universities;Variant


ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative Sugar-rich diets can promote disease by modifying gene expression and metabolism in the human gut microbiota. We are investigating how dietary sugar consumption silences the activity of a highly conserved bacterial transcription factor necessary for gut colonization. We have identified molecular determinants that control the activity of this transcription factor and propose to elucidate how host sugar consumption reduces its activity in vivo. Our study will reveal how modern industrialized diets influence the human gut microbiota and identify novel molecular targets to manipulate gut microbial composition and metabolism.

PI_NAMEs: TOWNSEND, GUY EDMUND (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: absorption;Autoimmune Diseases;Bacteroides;Bacteroides thetaiotaomicron;Bacteroidetes;Binding;Carbohydrates;Colitis;Colorectal Cancer;commensal bacteria;Consumption;Development;Diet;dietary;Dietary Sugars;Disease;Disease susceptibility;Distal;Exhibits;fitness;Fructose;Fucose;Gene Expression;Genes;Genetic Transcription;Glucose;Growth;gut bacteria;gut colonization;gut inflammation;gut microbes;gut microbiota;Health;Homologous Gene;host microbiota;host-microbe interactions;Human;human disease;Immune system;immunoregulation;In Vitro;in vivo;Individual;Industrialization;Inflammatory Bowel Diseases;Insulinase;Intestines;Ligands;Mammals;Mediating;Metabolic;Metabolism;metabolomics;microbial;microbial products;microbiota composition;Modernization;Molecular;Molecular Target;Mus;mutant;non-alcoholic fatty liver disease;novel;Pathogenesis;Pathway interactions;Peptide Hydrolases;Physiology;Polysaccharides;Population;Predisposition;Process;Proteins;Reducing diet;Regulatory T-Lymphocyte;Reporter;response;Rodent Model;Role;Signal Pathway;Signal Transduction;sugar;T cell differentiation;Thinness;transcription factor;transcriptomics;Work

PROJECT_TITLE: Elucidating the consequences of dietary sugar consumption on the gut microbiota

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lupus;Prevention

ORG_CITY: WORCESTER

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: NARRATIVE Autoimmune diseases affect up to 8% of the US population and its prevalence is rising, setting the stage for an impending public health crisis that we do not yet understand and are not prepared to face. We will leverage a multidisciplinary team of leading investigators, cutting edge tools designed for at-home, longitudinal tissue sampling, and an innovative strategy to discover how autoimmunity begins, relapses, and spreads in a large population of at-risk individuals. This approach will provide insight into autoimmunity that will help physicians better manage, or even prevent, devastating consequences of these diseases in the future.

PI_NAMEs: GARBER, MANUEL ;HARRIS, JOHN E (contact);IRVINE, DARRELL J;RASHIGHI, MEHDI

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Affect;Age of Onset;Autoantibodies;Autoimmune Diseases;Autoimmunity;Biological Markers;biomarker identification;Blood;Blood capillaries;Cells;Clinical;clinical diagnosis;Clinical Management;cohort;Collection;Cutaneous Lupus Erythematosus;Data;Dermatologist;design;Development;Devices;Diagnosis;Disease;Disease Marker;Disease Progression;Disproportionately impacts women;Engineering;Enrollment;Epithelial Cells;Exhibits;Face;Family member;Future;Gene Expression;Genetic;Genotype;Hazard Models;health disparity;High Prevalence;Home;Human;Immune;Individual;innovation;insight;Interferon Type I;interstitial;Liquid substance;Longitudinal cohort;Lupus;Methods;minimally invasive;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;multidisciplinary;multiple omics;Needles;Onset of illness;Organ;Participant;Patients;Physicians;Population;Populations at Risk;pre-clinical;predictive modeling;Prevalence;prevent;Property;Proteins;Proteomics;Public Health;Punch Biopsy;Questionnaires;Recurrent disease;Relapse;Reporting;Research Personnel;response;Risk;sample collection;Sampling;Scientist;Scourge;Serum;Severity of illness;single-cell RNA sequencing;Skin;skin color;skin disorder;Statistical Models;Systemic disease;Systemic Lupus Erythematosus;Testing;Time;Tissue Sample;Tissues;tool;transcriptome sequencing;UV induced;Vitiligo

PROJECT_TITLE: Predictive drivers of new onset, relapse, and progression of human autoimmunity in skin


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative Cancer immunosurveillance ascribes a role of cellular immunity in eliminating transformed cells. Cancer immunotherapy approaches exploiting such activity have produced durable responses in a subset of cancer patients. Experiments proposed in this project will define a novel regulatory process of immunosurveillance response mediated by tumor-associated macrophages, which can be targeted for therapy of a wide range of malignancies.

PI_NAMEs: LI, MING  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Ablation;anti-PD-1;Antigen Presentation;Antigen-Presenting Cells;Antigens;Attenuated;Bioenergetics;cancer cell;cancer immunotherapy;Cancer Model;Cancer Patient;cancer type;CD8-Positive T-Lymphocytes;Cell Compartmentation;Cell Differentiation process;cell growth;Cell Lineage;Cell Physiology;Cell Size;Cell Therapy;cell transformation;Cells;Cellular Immunity;Characteristics;Chromatin;Chronic;Complex;Cross Presentation;Cytokine Activation;Cytotoxic T-Lymphocytes;Dendritic Cells;Development;Dual-role transvestism;Enhancers;exhaust;exhaustion;Exhibits;experimental study;FRAP1 gene;Functional disorder;Gene Expression;Gene Expression Profile;Gene Mutation;Generations;Genes;Genetic;Genetic Enhancer Element;Genetic Models;genetic signature;Globulins;Growth Factor;Human;IFN consensus sequence binding protein;immune checkpoint blockade;Immunologic Surveillance;in vivo;inhibitor;insight;Interferon Type II;Interferons;Interleukin-15;loss of function;lymphoid organ;Macrophage;Major Histocompatibility Complex;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Metabolic;Metabolic Activation;Mononuclear;mouse model;Mouse Strains;Mus;neoantigens;notch protein;novel;Nutrient;overexpression;Oxygen;Phagocytes;Pharmacotherapy;Population;Process;progenitor;programmed cell death protein 1;programs;Proteins;receptor;recruit;Regulation;response;Role;Sampling;Signal Transduction;Specific qualifier value;System;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic Intervention;transcription factor;transcriptome;Transforming Growth Factor beta;Transforming Growth Factors;Transgenic Model;tumor;tumor growth;tumor microenvironment;Tumor Promotion;Tumor Tissue;Tumor-associated macrophages

PROJECT_TITLE: Antigen-Presenting Cell Control of CD8+ T Cell Exhaustion in Cancer

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Individuals who suffer from post-traumatic stress disorder (PTSD) are often at higher risk for developing comorbid alcohol use disorder (AUD). The studies in this project will provide broader understanding of the consequences of stressor exposure on alcohol interoceptive effects, which care a key component of alcohol drinking.

PI_NAMEs: BESHEER, JOYCE  (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: alcohol comorbidity;Alcohol consumption;alcohol effect;alcohol sensitivity;alcohol use disorder;Alcohols;antagonist;Anterior;Attenuated;Beds;Behavior;Behavioral;Caring;conditioning;Corticosterone;drinking;drug discrimination;experience;experimental study;Exposure to;Feces;foxes;Funding;Gene Expression;genetic approach;Glutamates;high risk;Immobilization;Individual;Individual Differences;innovation;interest;Literature;Measures;Mental disorders;Messenger RNA;Metabotropic Glutamate Receptors;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Neurobiology;Neurons;neurophysiology;Nucleus Accumbens;Odors;Pathology;Pathway interactions;Pharmacotherapy;Phenotype;Post-Traumatic Stress Disorders;pre-clinical;Pre-Clinical Model;prevent;Procedures;Rattus;receptor;receptor expression;Receptor Gene;response;Rodent Model;Self Administration;Signal Transduction;Stress;stress reactivity;stressor;Subgroup;System;Systems Development;Testing;Therapeutic;Time;Trauma;traumatic event

PROJECT_TITLE: Characterization of alcohol interoceptive effects following predator odor exposure: relevance to PTSD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-T(02)M]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: NARRATIVE Occupational exposures in women who work during their pregnancies can lead to poor reproductive outcomes, such as miscarriages or fetal malformations. The objective of this study is to evaluate the direct and multigenerational effects of the engineered nanomaterial, nano-titanium dioxide, on reproductive outcomes in females and how those may be mediated by vascular and oxidative stress mechanisms after maternal inhalation exposure. The fundamental knowledge discovered in these studies, along with the career development pursued by the investigator, will be used to identify ways to better protect the reproductive health of female workers in occupational settings as well as their daughters and potentially sons.

PI_NAMEs: BOWDRIDGE, ELIZABETH COMPTON (contact)

PROJECT_TITLE: Multi-generational Effects of Maternal Engineered Nano-Material Inhalation Exposure on Microvascular and Reproductive Health Outcomes

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


ADMINISTERING_IC: CK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Healthcare-associated infections (HAI) and antibiotic resistance (AR) cause patient suffering. This proposal from the Duke-UNC Prevention Epicenters Program includes four lines of investigation to decrease HAI, AR, and patient harm related to a) environmental disinfection, b) antimicrobial stewardship, c) diagnostic stewardship, and d) community-associated Clostridioides difficile infection (CDI). Utilizing unique collaborative, multicenter research infrastructure, these investigations aim to decrease risk for patients and will focus on novel strategies to prevent environmental contamination from hospital sinks, decrease overuse of antibiotics, improve utilization of urinalysis and urine culture for the diagnosis of urinary tract infections, and identify novel sources for community-associated CDI.

PI_NAMEs: ANDERSON, DEVERICK JOHN (contact)

PROJECT_TITLE: CK20-004, Duke-UNC Prevention Epicenter Program for Protecting Patients from Infections, Antibiotics Resistance and Other Adverse Events


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Breast cancer is the leading cancer among women, accounting for one-third of diagnosed cancers. While sus- picious mammographic ﬁndings may be clariﬁed with ultrasound imaging, a subset of ultrasound images yield inconclusive results, necessitating biopsies or follow-up procedures, which increase patient anxiety and places an additional burden on the time and resources of our healthcare system. The goal of this project is to develop ultrasound technology that will resolve existing ambiguities.

PI_NAMEs: BELL, MUYINATU A. LEDIJU (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: Accounting;Acoustics;Anxiety;Benign;Biometry;Biopsy;Board Certification;Breast;Breast Cancer Detection;breast malignancies;cancer diagnosis;Cancer Patient;Clinic;Clinical;clinical care;Clinical Pathways;Clutterings;Collaborations;Complex;Cyst;Data;Dedications;deep learning;deep neural network;Developing Countries;Development;Diagnosis;Diagnostic;Disease;Early Diagnosis;Environment;Equipment;experience;Faculty;follow-up;Goals;Healthcare;Healthcare Systems;Hospitals;Human body;Image;imaging modality;imaging scientist;Imaging Techniques;Imaging technology;improved;In Situ;innovation;Investigation;Length;Letters;Liquid substance;Liver;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of pancreas;Malignant neoplasm of testis;Malignant Neoplasms;Mammary Ultrasonography;Mammography;Mass in breast;men;Methods;Morbidity - disease rate;mortality;neural network architecture;novel;novel strategies;Organ;Pancreas;Pathology;Pathway interactions;Patients;Performance;photoacoustic imaging;Procedures;Publishing;radiologist;Reader;Real-Time Systems;Recording of previous events;Research;Research Personnel;Resource Allocation;Resources;rural area;screening;Series;Solid;Speed;success;Techniques;Technology;Testing;Time;tool;Ultrasonography;ultrasound;Uncertainty;United States;Universities;Wait Time;Woman;Work

PROJECT_TITLE: Minimizing Uncertainty in Breast Ultrasound Imaging with Real-Time Coherence-Based Beamforming

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Atrial fibrillation (AF) is one of the most common human cardiac arrhythmias and DM is an independent risk factor for AF. This application explores new treatment paradigms of encouraging inflammation resolution to prevent DM-associated AF.

PI_NAMEs: DUDLEY, SAMUEL C (contact)

PROJECT_TERMS: Applied Research;Arachidonate 12-Lipoxygenase;Arachidonic Acids;Arrhythmia;Atrial Fibrillation;Cardiac;Cardiac Myocytes;CCL2 gene;clinically relevant;Diabetes Mellitus;diabetic;Down-Regulation;Enzymes;Equilibrium;experimental study;Fatty Acids;fundamental research;GPR6 gene;Heart;Heart Atrium;Human;human tissue;improved;Inflammasome;Inflammation;Inflammatory;insight;Interleukin-1 beta;knock-down;Leucine-Rich Repeat;lipid mediator;Lipids;LOX gene;Macrophage;Metabolic syndrome;Metabolism;migration;Modeling;Morbidity - disease rate;mouse model;Mus;novel;Obesity;Oxidative Stress;Oxidoreductase;Patients;prevent;Prevention;Process;Production;receptor;Resolution;response;Risk;Risk Factors;Signal Transduction;systemic inflammatory response;Testing;Transmembrane Domain;Up-Regulation;Writing

PROJECT_TITLE: Resolution of inflammation and atrial fibrillation


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Primary Health Care;Rare Diseases;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE Some of the largest disparities in human papillomavirus vaccination rates exist in rural communities, which represent missed opportunities for cancer prevention. This study will implement and evaluate a novel practice- level intervention approach that engages the entire medical team to increase adolescent HPV vaccine delivery and completion in rural community-based primary care practices.

PI_NAMEs: RODRIGUEZ, ELISA MARIE (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: 12 year old;Address;Adolescent;Adolescent Behavior;Adopted;Adoption;Affect;Age;cancer prevention;Characteristics;Child;Childhood;Clinical;clinical practice;Clinical Trials;Cluster randomized trial;Communities;community based practice;community engaged research;Community Networks;COVID-19 pandemic;Disease;Disparity;Education;effectiveness testing;Environment;Evaluation;evidence base;Evidence based practice;experience;Family;Female Adolescents;Gender;geographic disparity;Goals;Group Practice;health care delivery;health care settings;Health system;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immunization;implementation framework;implementation science;improved;Incidence;innovation;Insurance;Interdisciplinary Study;Intervention;intervention effect;intervention program;Knowledge;Lead;Longitudinal Studies;Male Adolescents;Measures;Medical;Methods;Modeling;Monitor;Neisseria meningitidis;New York;New York City;novel;Outcome;patient population;Patients;Performance;Persons;Pertussis;Phase;Positioning Attribute;Practical Robust Implementation and Sustainability Model;Prevention education;primary care practice;primary care setting;Process;programs;Provider;Recommendation;Recording of previous events;recruit;Research;Research Design;Rural;rural area;Rural Community;rural counties;rural healthcare;Rural Population;rural setting;rural underserved;Sample Size;Site;socioeconomics;Solo Practices;System;Testing;trial design;Underrepresented Populations;underserved community;United States;United States National Institutes of Health;urban area;Vaccination;vaccination strategy;vaccine acceptance;vaccine delivery;vaccine hesitancy;Vaccines;Visit

PROJECT_TITLE: Implementation of evidence-based strategies to optimize HPV vaccination in rural primary care settings

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DREXEL UNIVERSITY

PHR: NARRATIVE / PUBLIC HEALTH RELEVANCE This longitudinal study examines the separate and combined population-level influences of nutrition policy interventions for schools and modifiable characteristics of food environments around schools on academic performance overall and related racial/ethnic disparities. The study will generate new evidence on the extent to population-level nutrition policy interventions targeted at the school environment reduce racial/ethnic gaps in academic performance, a strong predictor of education, which, in turn is a salient determinant of health.

PI_NAMEs: SANCHEZ, BRISA N (contact);SANCHEZ-VAZNAUGH, EMMA V.

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Adult;Affect;African American;Beverages;California;Characteristics;Child;Childhood;Cognition;Color;Communities;community intervention;community-centered;community-level factor;Data;design;Diet;Diet and Nutrition;Dietary intake;Dietary Intervention;Disparity;disparity reduction;Education;Effectiveness;English Language;Environment;environmental intervention;Equity;ethnic disparity;ethnic diversity;ethnic health disparity;Ethnic Origin;Evaluation;evidence base;Exposure to;Fatty acid glycerol esters;Food;food environment;food standard;Geography;Goals;good diet;Health;health determinants;health disparity;Hunger;improved;Individual;Inequality;Infrastructure;Intake;Intervention;Latino;Latino Population;Link;longitudinal design;Longitudinal Studies;Low income;Mathematics;Methodology;Natural experiment;Neighborhoods;Neurobiology;nutrition;Nutrition Policy;Nutritional;Pathway interactions;peer;Performance;Play;Policies;poor health outcome;Population;Population Heterogeneity;Price;Process;public health relevance;Race;racial disparity;racial health disparity;Reduce health disparities;Research;school environment;Schools;Series;Shapes;social determinants;social health determinants;Standardization;Students;Subgroup;sugar;Testing;Time;United States Department of Agriculture;United States National Institutes of Health

PROJECT_TITLE: Effectiveness of population level interventions in schools and academic performance

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Mechanistic target rapamycin mTOR complex 1 (mTORC1), an evolutionarily conserved protein kinase complex, functions as a central controller of cell growth and proliferation. This proposal will investigate new upstream regulators for cellular mTORC1 activity. Our overarching goals are to understand how ubiquitinated Rheb-centered menbraneless structure facilitates mTORC1 activation and amplifies specific downstream signaling essential for cell growth and proliferation and organ homeostasis.

PI_NAMEs: INOKI, KEN  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Ablation;Affect;Amino Acids;Aspartate;Binding;Biogenesis;cancer cell;Carbamyl Phosphate;cell growth;Cell Proliferation;Cells;Code;Complex;Cullin Proteins;cullin-3;Data;Databases;density;Dihydroorotase;Enzymes;Epithelial Cells;FRAP1 gene;Functional disorder;Generations;Goals;Growth;Growth Factor;Homeostasis;in vivo;insight;Kidney;knock-down;Knockout Mice;Ligase;Lipids;Liver;lysosome membrane;Lysosomes;Machado-Joseph Disease;Mediating;Membrane;Molecular;Monomeric GTP-Binding Proteins;multicatalytic endopeptidase complex;Mus;Mutation;NF-kappa B;novel;nucleotide metabolism;Nucleotides;Organ;Pathway interactions;Physiological;Play;podocyte;Polyubiquitination;Post-Translational Protein Processing;preference;Process;Proliferating;Protein Kinase;Protein-Serine-Threonine Kinases;Proteins;Proteomics;Pyrimidine;recruit;Recruitment Activity;Regulation;Reporting;response;Role;Signal Transduction;Starvation;Structure;Surface;Tissues;transcarbamylase;Ubiquitin;ubiquitin isopeptidase;ubiquitin ligase

PROJECT_TITLE: Molecular mechanism of Rheb-dependent mTORC1 regulation

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Asthma;Health Effects of Indoor Air Pollution;Lung

ORG_CITY: ORLANDO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: Currently, there is still a need for the development of novel treatments for asthma which can change the asthmatic disease course rather than simply manage it. Since around half of all asthmatics suffer from an allergic form of the disease, understanding how our body recognizes allergens may be important in trying to prevent the establishment of an allergic state and the progression to allergic asthma. The present study seeks to characterize how the protein LMAN1 recognizes and downregulates the inflammatory responses to allergens, which may, in turn, provide support for future targeting of LMAN1 for the treatment of allergic asthma.

PI_NAMEs: TIGNO-ARANJUEZ, JUSTINE TIGLAO (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: adaptive immune response;Adoptive Transfer;Adrenal Cortex Hormones;Affect;Agonist;airborne allergen;airway epithelium;airway hyperresponsiveness;airway inflammation;Allergens;Allergic;allergic airway inflammation;Allergic inflammation;allergic response;Antibody Formation;Asthma;asthma model;asthmatic;Attenuated;Binding;Biochemical;biological adaptation to stress;Biological Assay;Biological Products;Bone Marrow;Cell Line;Cell surface;Chimera organism;Chronic;cytokine;Cytoplasmic Tail;Data;Dendritic Cells;design;Development;Disease;Dose;Down-Regulation;efficacy testing;EMSA;endoplasmic reticulum stress;Engineering;Epithelial Cells;Event;Exposure to;Extrinsic asthma;Flow Cytometry;Future;Golgi Apparatus;Histopathology;Immune response;In Vitro;in vivo;Individual;Inflammatory;Inflammatory Response;Inhalation;interest;Knockout Mice;Knowledge;Laboratories;Lectin;Life;Ligands;Luciferases;Lung;Mannose;Mannose Binding Lectin;Mediator;Medicine;Modeling;Molecular;molecular drug target;mutant;NF-kappa B;novel;novel therapeutics;Pathway interactions;Persons;Phenotype;Play;prevent;Process;Production;protein function;Proteins;Pyroglyphidae;Quality of life;receptor;Recommendation;Regulation;Reporting;Respiratory Tract Infections;response;Risk Factors;Role;sensor;Severities;Shapes;Signal Transduction;Structure;Surface;symptom management;Symptoms;T cell response;targeted treatment;Testing;Therapeutic;therapeutic target;therapy development;valosin-containing protein;Western Blotting

PROJECT_TITLE: Cell surface LMAN1 as a General Sensor and Negative Regulator of Mannosylated Aeroallergens

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE Latinx individuals in the US are lonelier than non-Latinx White individuals, and Latinx individuals who drink consume more alcohol, engage in more hazardous drinking, and experience disproportionately greater alcohol problems than White individuals who drink. This project will identify precursors of loneliness in hazardous- drinking Latinx individuals and explain the link between loneliness and the development of problem drinking in this population. This research will fill an important gap in explaining the underlying social-cognitive, behavioral, interpersonal, and cultural mechanisms contributing to loneliness and alcohol problems in Latinx individuals, and it will have broad application to many additional health disparity populations.

PI_NAMEs: DERRICK, JAYE L (contact)

PROGRAM_OFFICER_NAME: RUFFIN, BEVERLY

PROJECT_TERMS: Acceleration;Acculturation;Alcohol abuse;alcohol consequences;Alcohol consumption;Alcohols;Area;Attention;Back;Behavioral;cisgender;Cognitive;college;Communities;Conflict (Psychology);Consumption;contextual factors;coping;Crowding;Cues;Data;design;Development;Disparity;drinking;Ecological momentary assessment;experience;Feeling;First Generation College Students;Gender Identity;gender minority group;hazardous drinking;Health;health disparity populations;Heterosexuals;Hispanic Populations;improved;Individual;innovation;Latinx;Latinx population;Lead;Link;Location;Loneliness;loved ones;Mainstreaming;Mental Health;Modeling;Monitor;National Institute on Alcohol Abuse and Alcoholism;Not Hispanic or Latino;novel;Participant;Patient Self-Report;Personal Satisfaction;Persons;physical conditioning;Population;population health;Process;psychologic;Recovery;Research;Risk Factors;Sampling;sensor;Sexual and Gender Minorities;sexual identity;sexual minority group;social;Social Environment;social factors;Source;Structure;substance misuse;Testing;Time;United States Substance Abuse and Mental Health Services Administration;wearable device

PROJECT_TITLE: Acculturation, Social Context, Loneliness, and the Development of Alcohol Problems in Latinx Individuals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-P(90)S]


ORG_CITY: DETROIT

ORG_NAME: HENRY FORD HEALTH SYSTEM

PHR: The proposed research is relevant to public health because it addresses a major health problem associated with enzalutamide-resistant prostate cancer (ERPC) which is currently incurable and is taking thousands of lives every year (~34,500 deaths projected for the year 2022) primarily because ERPC cells are resistant to available therapeutic regimen in the clinic. Interestingly, we found that a pseudokinase, called Tribbles 2 (Trib2), is overexpressed in ERPC cells and tumors and inhibition of Trib2 decreases the viability of ERPC cells, suggesting that Trib2 plays a seminal role in ERPC phenotype and that Trib2 may turn out to be an attractive, novel target for prevention and therapy of ERPC. Thus, this project has been designed, which is focused to understand the regulation and role of Trib2 in ERPC cells, and to examine the in vivo effects of targeting Trib2 using mouse models, with a goal to develop a new molecularly targeted therapeutic strategy against ERPC.

PI_NAMEs: GHOSH, JAGADANANDA  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: abiraterone;Address;Adenocarcinoma;Age;Androgen Antagonists;Androgen Receptor;androgenic;Apoptosis;Binding;bone;Bypass;Cancer Cell Growth;Castrate sensitive prostate cancer;Castration;Cell Culture Techniques;cell killing;Cell Line;cell type;Cells;Cessation of life;Characteristics;Chromogranin A;Clinic;Clinical;clinically relevant;design;Development;Distant Metastasis;Dose;effective therapy;Environment;enzalutamide;Epithelium;Exons;EZH2 gene;Family;FDA approved;Gene Chips;Gene Expression;Gene Expression Profiling;Gene Targeting;Generations;Goals;Health;Image;Immunoprecipitation;In Vitro;in vivo;in vivo Model;Induced Neurons;inhibitor;Injections;Kidney;knock-down;Knock-out;knockout gene;Knockout Mice;Knowledge;Link;Liver;LNCaP;Luciferases;Lung;male;Malignant neoplasm of prostate;Mass Spectrum Analysis;Measures;Medical;member;Metastatic to;Modeling;Molecular;molecular marker;Molecular Target;molecular targeted therapies;Monitor;mouse model;Movement;multicatalytic endopeptidase complex;Mus;Neoplasm Metastasis;neuroendocrine differentiation;neuroendocrine phenotype;Neuroendocrine Therapy;Neuron-Specific Enolase;Neurosecretory Systems;new therapeutic target;novel;overexpression;Pathologic;Patients;Phenotype;Play;Population;pre-clinical;Prevention;profiles in patients;Prostate;prostate cancer cell;prostate cancer cell line;prostate cancer model;prostate cancer progression;Prostate Neuroendocrine Neoplasm;Prostatic Neoplasms;Proteins;Public Health;receptor function;Regimen;Regulation;Research;Resistance;Role;Sampling;SCID Mice;Seminal;Synaptophysin;Testing;Therapeutic;therapy development;therapy resistant;TP53 gene;transcription factor;transdifferentiation;Transgenic Mice;Transgenic Organisms;tumor;tumor growth;tumor progression;Up-Regulation;Work;Xenograft procedure

PROJECT_TITLE: Neuroendocrine differentiation post anti-androgenic therapy: Role of Tribbles 2

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Comparative Effectiveness Research;Contraception/Reproduction;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE Urinary tract infections (UTIs) are common during pregnancy and can cause serious maternal and neonatal consequences, but current clinical guidelines fail to provide guidance for first trimester management of UTI due to uncertainty about the relative benefits and harms of commonly used antibiotic regimens. Our proposed study will evaluate the utilization, effectiveness, and safety of commonly-used antibiotic regimens in pregnant women treated for outpatient UTI. Ultimately, the evidence generated by this study will inform clinical guidelines and antibiotic prescribing, which will lead to better outcomes in pregnant women and infants, improved antimicrobial stewardship, and improved long-term bacterial susceptibility to antibiotics.

PI_NAMEs: BUTLER, ANNE MOBLEY (contact)

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: Address;administrative database;Adverse drug event;Adverse event;Affect;Ambulatory Care;American College of Obstetricians and Gynecologists;anti-microbial drug;Anti-microbial susceptibility;Antibiotic Resistance;antibiotic resistant infections;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteriuria;Benefits and Risks;beta-Lactams;Calendar;Cardiac;Clinical;clinical decision-making;Clinical Trials;Clostridium difficile;comparative safety;Congenital Abnormality;cost efficient;Data;Databases;Diarrhea;early pregnancy;Effectiveness;effectiveness analysis;Electronic Health Record;epidemiology study;Evaluation;Exanthema;Exclusion;First Pregnancy Trimester;follow-up;Geographic Locations;Gestational Age;Guidelines;Healthcare Systems;Hypersensitivity;improved;Infant;insight;kidney infection;Knowledge;Low Birth Weight Infant;Microbiology;microbiome;Modernization;Neonatal;Nitrofurantoin;Obesity;Observational Study;optimal treatments;oral cleft;Outcome;Outpatients;pathogen;Patients;Pattern;perinatal complications;perinatal outcomes;Pharmaceutical Preparations;Population Heterogeneity;Predisposition;Pregnancy;pregnant;Pregnant Women;Premature Birth;Premature Labor;prevent;prospective;randomized trial;randomized, clinical trials;Recommendation;Recording of previous events;Regimen;Research Design;Risk;Risk Estimate;Safety;Sample Size;screening guidelines;Second Pregnancy Trimester;Sepsis;Smoking Status;standard care;standard of care;stillbirth;Sulfonamides;Teratogens;Third Pregnancy Trimester;Time;treatment duration;Treatment Failure;Treatment Protocols;treatment risk;Uncertainty;urinary;Urinary tract infection;Uropathogen;Variant;Woman;women's treatment

PROJECT_TITLE: Identifying Optimal Antibiotic Regimens to Treat Urinary Tract Infections During Pregnancy

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: VAN NUYS

ORG_NAME: TRACE-ABILITY, INC.

ORG_STATE: CA

PHR: Achievement of the project aims will put Trace-Ability in position to support all manufacturers of cancer PET drugs in their full capacity with a fully-automated QC solution. The impact in the field of Oncology will be manifested in increased availability of FDG and other cancer PET scans and facilitation of new tracer development. Such availability is currently limited by throughput and compliance issues in PET drug QC, which Tracer-QC has proven to address successfully, but needs scalable kit production to offer the enabling benefits to the entire industry.

PI_NAMEs: ELIZAROV, ARKADIJ  (contact)

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: Acetonitriles;Achievement;Address;Aliquot;Automation;base;Biological Assay;Businesses;Cancer Patient;cancer type;Clinic;clinical imaging;Color;comparative;Contrast Media;cost;Data Analyses;Deoxyglucose;design;Development;Devices;drug quality;Endotoxins;Ensure;Equipment;Ethanol;Freezing;Half-Life;Health;high risk;imaging modality;industrial production;Industry;Injections;innovation;Malignant Neoplasms;Manuals;manufacture;Manufacturer;manufacturing process;manufacturing scale-up;manufacturing technology;Measurement;Methods;Molds;Molecular;new technology;Oncology;operation;Optics;patient population;Patients;Performance;Pharmaceutical Preparations;Phase;Positioning Attribute;Positron-Emission Tomography;Problem Solving;Procedures;Process;Production;Quality Control;Radioactive;Radioactivity;Reader;Records;Recurrence;Reporting;Risk;Sampling;scale up;Site;skills;standard of care;System;Technology;Testing;tool;Tracer;tumor;Validation;validation studies;Visual;Work

PROJECT_TITLE: Establishing industrial production of components that enable expanding accessibility of PET imaging to cancer patient population.


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Project Narrative Post-Traumatic Stress Disorder (PTSD) is a devastating mental illness with limited treatment options. Recent large-scale genomic studies identified Foxp2 transcription factor as having a significant contribution to this and other psychiatric diseases, however, the molecular mechanisms by which Foxp2 contributes to PTSD symptomatology are unknown. I propose a mechanistic approach to define upstream mediators and downstream targets of Foxp2 within specific cell-types and circuits that are implicated in fear-related behaviors in adult mice.

PI_NAMEs: PONOMAREVA, OLGA Y (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Address;Adult;Adult women;Affect;Amygdaloid structure;Animal Disease Models;Animals;antagonist;Attention deficit hyperactivity disorder;Award;Behavior;Behavioral;behavioral study;beta catenin;cell type;Cells;Child Abuse and Neglect;Cohort Studies;conditioned fear;Corpus striatum structure;Data;depressive symptoms;Development;Disease;disease model;Down-Regulation;emotion regulation;Emotional;Emotions;Estrous Cycle;experience;Extinction;fear memory;Feedback;Female;forkhead protein;FOXP2 gene;Fright;Funding;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;genome wide association study;genome-wide;Genomics;Goals;inhibitor;Intercalated Cell;Ion Channel;knock-down;Knock-out;knockout gene;Language Development;Learning;Learning Disorders;Literature;Lithium;male;marijuana use disorder;mature animal;Mediating;Mediator;member;Memory;memory consolidation;memory process;Mental disorders;Messenger RNA;Molecular;Molecular Biology;Molecular Genetics;Molecular Target;Mus;nervous system development;neural circuit;neuromechanism;Neurons;neuropsychiatric disorder;overexpression;Pathway interactions;Peptides;personalized medicine;Physicians;Population;Post-Traumatic Stress Disorders;Regulation;Reporting;Research Proposals;Resolution;response;Reverse Transcriptase Polymerase Chain Reaction;Risk;Role;Scientist;Sex Differences;Shock;Short-Term Memory;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;skills;symptomatology;Testing;Time;Tissue-Specific Gene Expression;Training;transcription factor;Transcriptional Regulation;WNT Signaling Pathway;Work

PROJECT_TITLE: Understanding Foxp2-Mediated Molecular Signaling in Fear Learning

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Characterization of somatic variation in human tissues is fundamental to our understanding of disease processes. We will develop a platform for data collection, curation, analysis, and visualization for the Somatic Mosaicism across Human Tissues (SMaHT) Network. The variant catalog, workbench, and data portal we develop will enable the scientiﬁc community to take advantage of the data, tools, and technologies developed by the Network. 2

PI_NAMEs: PARK, PETER J (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: archive data;Benchmarking;Bioinformatics;bioinformatics tool;Biological Assay;Biological Process;Catalogs;Cell Fraction;ClinVar;Cloud Computing;cloud platform;cohort;Communities;Complex;computational pipelines;Computer software;Computing Methodologies;Consult;Controlled Environment;Copy Number Polymorphism;Data;data access;Data Analyses;data analysis pipeline;data and analysis portal;Data Collection;data ecosystem;data management;data modeling;data platform;data portal;Data Set;data sharing;data standards;data submission;data visualization;Databases;design;Detection;detection method;Development;Diploidy;Disease;DNA Insertion Elements;DNA Sequence Rearrangement;DNA Transposable Elements;Ensure;Environment;experience;flexibility;Funding;Genome;genome-wide;Genomics;Goals;Haplotypes;Health;human tissue;Image;improved;Individual;Ingestion;insertion/deletion mutation;interactive visualization;International;Intuition;Knowledge;large scale data;Lead;Malignant Neoplasms;Measures;member;Metadata;metadata standards;Methods;Microsatellite Repeats;mosaic variant;Mosaicism;Mutation;novel strategies;Population Heterogeneity;Positioning Attribute;Process;Protocols documentation;Quality Control;Regulation;Reproducibility;Research Personnel;Resources;Role;Sampling;Scheme;Scientist;Secure;single cell technology;Single Nucleotide Polymorphism;Software Engineering;Standardization;Technology;Testing;Tissue Procurements;Tissues;tool;United States National Institutes of Health;user-friendly;Variant;variant detection;Visual;Visualization;Visualization software;web services;Work

PROJECT_TITLE: Data Analysis Center for Somatic Mosaicism Across Human Tissues Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-D(70)R]