ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Data Science;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE Computed Tomography (CT) images play an integral role in screening and diagnosing lung cancer, interstitial lung disease, and stroke. While quantitative image features can facilitate accurate characterization of diseases, these features are highly sensitive to variations in how the CT images are acquired and reconstructed, negatively impacting their reproducibility and the performance of machine learning models that utilize these features. This project investigates the effects of varying CT parameters on these image-derived features and uses that infor- mation to identify optimal techniques to mitigate their effects in a task-dependent manner.

PI_NAMEs: HSU, WILLIAM  (contact);MCNITT-GRAY, MICHAEL F

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Academia;Address;Adopted;Adoption;Affect;Agreement;Algorithms;Area;Back;biomarker development;biomarker validation;Brain Ischemia;brain tissue;Characteristics;Chest imaging;Classification;Clinical;clinical practice;clinical translation;Clinical Trials;Collaborations;Collection;Communities;computed tomography screening;computerized tools;Coupled;Data;Data Set;Detection;Development;Diagnosis;Diagnostic;Disease;disease phenotype;Disease Progression;Dose;Ensure;Fostering;Goals;Head;High Resolution Computed Tomography;Image;Image Analysis;improved;Industry;Industry Collaboration;Infarction;innovation;Institution;Interstitial Lung Diseases;Ischemia;large datasets;Link;Lung nodule;Machine Learning;machine learning model;Malignant neoplasm of lung;Maps;Medical Imaging;Methods;Modeling;Morphology;multidisciplinary;neural network;Nodule;novel;open source;open source tool;Outcome;Patient-Focused Outcomes;Patients;Performance;Photons;Physics;Play;predictive modeling;Process;process improvement;Proliferating;prospective;Protocols documentation;Publications;Pulmonary Emphysema;quantitative imaging;Radiation Dose Unit;radiomics;reconstruction;Reproducibility;Research;Resources;Role;Scanning;screening;Seminal;Severity of illness;Slice;Software Tools;Source;Standardization;Stroke;Surrogate Endpoint;Techniques;Technology;Texture;Thick;Thinness;tool;Training;Variant;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Computational Toolkit for Normalizing the Impact of CT Acquisition and Reconstruction on Quantitative Image Features

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Orphan Drug;Rare Diseases

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative We find that disruption of lipid metabolism triggers a novel form of cell death in sarcoma and other cancer cells. These studies will investigate the biochemical regulation of this cell death mechanism and its potential application to the treatment of cancer.

PI_NAMEs: DIXON, SCOTT  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Acyltransferase;Aggressive Fibromatosis;analog;Animal Cancer Model;Animal Model;Antineoplastic Agents;Apoptosis;Apoptotic;Biochemical;cancer cell;Cancer Model;cancer therapy;Caspase;Cell Death;Cell Death Induction;Cell Line;cell type;Clinical;Clinical Research;Clinical Treatment;Clinical Trials;Coenzyme A;Connective Tissue;conventional therapy;design;drug candidate;Elements;Enzymes;Fatty Acids;Future;Genes;Genetic Screening;Genetically Engineered Mouse;genome-wide;Goals;Human;Image;improved outcome;in vivo;innovation;interest;Investigation;Lecithin;Link;lipid metabolism;lipidomics;Lipids;Lysophospholipids;Malignant Neoplasms;Mesenchymal Cell Neoplasm;Metabolic;Metabolism;Modeling;molecular marker;Names;NF-kappa B;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oxidoreductase;Palmitates;Palmitoyl Coenzyme A;palmitoylation;Pathway interactions;Patients;Post-Translational Protein Processing;protein transport;Proteins;Regulation;Research;Resistance;Role;Sarcoma;small molecule;Soft tissue sarcoma;targeted cancer therapy;Testing;Therapeutic;Therapeutic Effect;therapeutic target;tool;Toxic effect;Tumor Suppressor Proteins

PROJECT_TITLE: Triggering a New Cancer Cell Death Mechanism in Sarcoma

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE The goal of this project is to establish APOE-genotype-dependent and cell type-specific connectivity maps covering ~12,000 drugs demonstrated safety in humans, using human iPSC-derived brain cells. We will then apply these connectivity maps to Alzheimer’s disease drug repurposing and test the identified top candidate drugs in a novel mouse model of Alzheimer’s disease.

PI_NAMEs: HUANG, YADONG  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Acceleration;Address;Age of Onset;Algorithms;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Animals;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Area;Astrocytes;Bar Codes;brain cell;Bumetanide;Cell Nucleus;cell type;Cells;Central Nervous System;Central Nervous System Agents;Central Nervous System Diseases;Computer Analysis;Consumption;cost;Data;Data Set;Databases;Development;differential expression;Dimethyl Sulfoxide;Disease;Dose;drug candidate;drug development;drug repurposing;Drug Targeting;drug testing;Environmental Risk Factor;excitatory neuron;Formulation;Gene Expression;Gene Expression Profile;Genes;Genetic;Genomics;Genotype;Goals;Hour;Human;human induced pluripotent stem cells;induced pluripotent stem cell;inhibitory neuron;large-scale database;Libraries;Malignant Neoplasms;manufacture;Maps;Microglia;Molecular;Molecular Profiling;mouse model;Nature;Neurodegenerative Disorders;Neurons;novel;novel therapeutics;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacotherapy;Process;Protein Isoforms;Proteins;public database;Reporting;research and development;Resources;Safety;screening;single-cell RNA sequencing;success;tau Proteins;Testing;Therapeutic;Therapeutic Agents;Time;Toxicology;transcriptomics;Validation;whole genome

PROJECT_TITLE: Develop AD Connectivity Maps with Human iPSC-Derived Brain Cells and their Use


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Lung;Pulmonary Hypertension

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Many different types of heart disease can ultimately lead to disease of the lung vessels. Lung vessel disease causes worsening of symptoms and shortens life expectancy in patients with heart disease. This project will study lung vessel changes in heart disease to find new treatments that improve symptoms and survival for patients with heart disease.

PI_NAMEs: BORLAUG, BARRY A.;REDFIELD, MARGARET M (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Address;Adult;Aerobic;Anatomy;Animal Model;Autopsy;Back;Bioinformatics;Biological;Biology;Blood capillaries;Blood Vessels;Circulation;Classification;Clinical;Data;differential expression;Disease;effective therapy;Epidemiology;Exertion;fasudil;FRAP1 gene;Functional disorder;Glean;Goals;Heart Diseases;hemodynamics;Histologic;Human;individualized medicine;innovation;kinase inhibitor;Knowledge;laser capture microdissection;Left;Life Expectancy;Link;Localized Disease;Location;Lung;Lung Diseases;Mass Spectrum Analysis;Mediating;Miniature Swine;Morbidity - disease rate;mortality;Nature;Neonatal;novel;novel strategies;novel therapeutics;Outcome Study;Outcomes Research;Pathway interactions;Patients;personalized therapeutic;Phenotype;porcine model;pressure;Prognosis;programs;Proteins;Proteomics;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary arterial remodeling;Pulmonary Heart Disease;Pulmonary Hypertension;pulmonary vascular disorder;Pulmonary Vascular Resistance;pulmonary venous hypertension;Research;response;Rho-associated kinase;right ventricular failure;Severities;Signal Transduction;Sirolimus;stem;Structure of parenchyma of lung;symptomatic improvement;Symptoms;System;Techniques;Terminology;Therapeutic;Therapeutic Agents;therapeutic target;transcriptomics;treatment response;Vascular remodeling;vasoconstriction;Venous;Ventricular;Work

PROJECT_TITLE: Pulmonary Hypertension in Left Heart Disease

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: NEW HAVEN

ORG_DEPT: DERMATOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Discoid lupus erythematosus is a chronic disfiguring autoimmune skin disease characterized by an immune cell infiltrate predominantly composed of T lymphocytes, which appear to promote tissue inflammation and damage, but how they do so is not well understood. I will perform translational immunologic research on human skin and blood samples with parallel studies in a mouse model to delineate the roles of key survival, inflammatory, cytotoxic, and other effector pathways in potentially pathogenic T lymphocytes, and to probe how they are regulated. These efforts will advance our understanding of discoid lupus erythematosus and help identify targeted strategies for treating this disease.

PI_NAMEs: LITTLE, ALICIA  (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Address;Adoptive Transfer;Advisory Committees;Affect;African American Women;Alopecia;antagonist;Atrophic;Autoimmune;Autoimmune Diseases;Bar Codes;Biometry;Blood;Blood specimen;Bone Marrow;career development;Cell Separation;Cell Survival;Cells;Cellular biology;Chimera organism;Chronic;Cicatrix;clinical investigation;Clonal Expansion;Clone Cells;comparative;Cutaneous;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Dermatology;Development;Diagnosis;Discoid Lupus Erythematosus;Disease;draining lymph node;effector T cell;Environment;exhaustion;Flow Cytometry;Fluorescent in Situ Hybridization;FOXP3 gene;Future;Gene Expression Profile;Genes;genetic signature;Granzyme;Head and neck structure;Human;Hypopigmentation;Hypoxia;Hypoxia Inducible Factor;hypoxia inducible factor 1;Imaging Techniques;immune cell infiltrate;Immunobiology;Immunofluorescence Immunologic;Immunologics;Impairment;Infiltration;Inflammation;Inflammatory;Inflammatory Infiltrate;Injury;Kidney;Laboratories;Lesion;Lupus;lupus prone mice;Maps;Mediating;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Natural Killer Cells;new therapeutic target;novel;novel therapeutics;Pathogenicity;Pathway interactions;Patients;pharmacologic;Phenotype;Physicians;Population;Production;programs;PTPRC gene;Quality of life;reconstitution;Regulatory T-Lymphocyte;Research;research study;response;Role;Scientist;Signal Transduction;single-cell RNA sequencing;Site;Skin;skin damage;skin disorder;skin lesion;Skin Tissue;Systemic disease;Systemic Lupus Erythematosus;T cell infiltration;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Techniques;Testing;Therapeutic;tissue injury;Tissues;Training;transcription factor;transcriptomics;translational immunology;Translational Research;Work

PROJECT_TITLE: Pathogenic T cells in discoid lupus erythematosus

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: MADISON

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE In this application, a groundbreaking abdominal CT imaging paradigm will be implemented to generate spectral CT images from a single-kV CT acquisition and translated into clinical practices for wide clinical dissemination. This new paradigm will enable quantitative spectral CT imaging for all current and future CT exams without requiring expensive hardware modifications. This new paradigm will provide precise medical disease diagnosis while facilitating clinical workflow, thereby reducing the overall healthcare cost in conjunction with reducing radiation risks associated with current CT imaging.

PI_NAMEs: CHEN, GUANG-HONG  (contact);LUBNER, MEGHAN GALVIN;QI, ZHIHUA

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: Abdomen;abdominal CT;absorption;Academic Medical Centers;Address;adenoma;Adrenal Glands;Anatomy;Attenuated;attenuation;Clinical;clinical application;clinical diagnostics;clinical implementation;clinical practice;clinical translation;community clinic;Community Hospitals;Compton radiation;Computed Tomography Scanners;contrast enhanced;contrast enhanced computed tomography;Data;Data Set;detector;Developing Countries;Development;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic tool;disease diagnosis;Dose;Elements;Environment;Evaluation;experience;Future;Health Care Costs;Hospitals;Image;image reconstruction;imaging facilities;imaging modality;imaging system;Imaging Techniques;improved;Incidental Findings;innovation;Iodine;Lipids;Magnetic Resonance Imaging;Maps;Measurement;Measures;Medical;Methods;Modern Medicine;Modernization;Modification;Nodule;novel;Pathway interactions;Patients;Penetration;Performance;Phase;Photons;Process;quantitative imaging;Radiation Dose Unit;radiation risk;Radiology Specialty;Research;Resolution;Roentgen Rays;Scanning;Series;Signal Transduction;Source;spectral energy;Speed;success;System;Techniques;Technology;technology platform;temporal measurement;tool;Translating;Tube;uptake;virtual;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: Clinical Translation of a One-Stop-Shop Imaging Method for Abdominal CT

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: HD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: Project Narrative. The proposed research is relevant to public health because they have the potential to provide a better understanding of which young children are at high risk of metabolic consequences of obesity. Thus, the advances proposed are expected to have a high impact to the health and wellbeing of all US citizens because metabolic diseases, such as obesity and its complications, are currently the number one killers of adults, and are becoming epidemic in children as well. This is relevant to the part of NIH's mission which focuses on the prevention of disease by supporting research in the diagnosis of human diseases.

PI_NAMEs: HEYMSFIELD, STEVEN ;SHEPHERD, JOHN ALAN (contact)

PROGRAM_OFFICER_NAME: CLARK, DAVID

PROJECT_TERMS: 3-Dimensional;6 year old;Address;Adolescent obesity;Adult;Age;Air;Anthropometry;arm;Award;Biometry;Birth;Black race;Body Composition;Body mass index;Body Size;Body Water;Calibration;cancer risk;cancer type;Cardiovascular Diseases;Characteristics;Child;Childhood;clinical practice;Clinical Research;clinically relevant;computer scientist;Computers;Data;demographics;Descriptor;Development;Diagnosis;Dietary Factors;Discipline of Nursing;Disease;Disease Resistance;disorder prevention;disorder risk;Dual-Energy X-Ray Absorptiometry;early childhood;Epidemic;ethnic diversity;experience;Failure to Thrive;Fatty acid glycerol esters;Fluid Shifts;Goals;Grant;Health;health determinants;high risk;human disease;Hydration status;Image;Incidence;Insulin Resistance;International;Intervention;Investigation;Leg;Length;Life;Life Cycle Stages;Link;Machine Learning;Malignant Neoplasms;Manuals;Measurement;Measures;Medical Imaging;Metabolic;Metabolic Diseases;metabolomics;Methods;Mission;Modeling;Modernization;Monitor;Movement;muscle form;National Institute of Diabetes and Digestive and Kidney Diseases;nutrition;Obesity;obesity in children;obesity prevention;obesity risk;Optics;Outcome;Participant;pediatrician;Personal Satisfaction;Phenotype;Play;Plethysmography;Population;population stratification;predictive modeling;Public Health;Qualifying;rapid weight gain;recruit;Research;Research Personnel;Research Support;Resolution;Resources;Risk;Role;Scanning;sensor;sex;Shapes;Spectrum Analysis;Speed;Study models;Technology;Thinness;Time;tool;United States National Institutes of Health;Visualization;Weight;whole body imaging

PROJECT_TITLE: Quantifying body shape in pediatric clinical research

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Kidney Disease

ORG_CITY: STONY BROOK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: PROJECT NARRATIVE / RELEVANCE STATEMENT Kidney disease is a major public health problem due to high treatment costs, mortality, and high comorbidities with other major diseases such as diabetes, hypertension, and cardiovascular disease. The proposed project is highly relevant for the health of citizens of the U.S. because glomerular disease is the third most common cause of end stage kidney disease in the U.S. This project will enable significantly improved molecular understanding of PPARγ-mediated mechanisms and therapeutic exploitation of this nuclear receptor by next generation modulators for targeted therapies for glomerular disease with reduced side effects.

PI_NAMEs: AGRAWAL, SHIPRA  (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Adipocytes;Adverse effects;Agonist;Albumins;Animal Model;Anti-diabetic Drugs;ATAC-seq;Binding;Cardiovascular Diseases;ChIP-seq;Chronic Kidney Failure;Clinical;clinical application;Clinical Trials;comorbidity;Cytoskeleton;Data;Development;Diabetes Mellitus;Disease;Disease Progression;Drug Kinetics;Economic Burden;effective therapy;efficacy evaluation;End stage renal failure;Event;Filtration;Functional disorder;Genes;Genetic Transcription;Goals;Health;Human;Hypertension;improved;Injury;Kidney Diseases;Knowledge;lead series;lipid biosynthesis;Lipids;Mediating;Medical;Messenger RNA;Modeling;Molecular;mortality;Nephrotic Syndrome;next generation;novel;novel strategies;Nuclear Receptors;oligonucleotide therapeutics;Outcome;Pathway interactions;Peroxisome Proliferator-Activated Receptors;Pharmacodynamics;Pioglitazone;Plasminogen Activator Inhibitor 1;podocyte;Polyadenylation;posttranscriptional;PPAR gamma;pre-clinical;protective effect;Proteinuria;PTGS2 gene;Public Health;Publishing;Rattus;Refractory;Regulation;Renal glomerular disease;Reporting;Repression;RNA Splicing;Role;side effect;Signal Transduction;Site;slit diaphragm;Structure;targeted treatment;Testing;Therapeutic;Thiazolidinediones;Toxic effect;Toxin;Transactivation;Transcriptional Regulation;transcriptomics;Treatment Cost;Variant;WT1 gene

PROJECT_TITLE: Mechanisms and Selective Modulation of PPARy for the Treatment of Podocytopathies

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: NEWARK

ORG_NAME: NORTH JERSEY AIDS ALLIANCE ,INC. (NJCRI)

ORG_STATE: NJ

PHR: Project Narrative As recent outbreaks confirm, the threat of HIV among people who inject drugs in the US is not over. In New York City, those who started injecting drugs in Puerto Rico are the most HIV, HCV, and overdose vulnerable ethnic group. This proposed culturally appropriate intervention will integrate HIV, HCV, and overdose prevention knowledge and practices in migrants’ everyday lives to reduce the significant potential for an HIV outbreak.

PI_NAMEs: GELPI-ACOSTA, CAMILA  (contact);GUARINO, HONORIA M

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: AIDS prevention;Air;analog;Behavioral;Boston;Client;Clinical Trials;Consultations;County;culturally appropriate intervention;Data;Death Rate;design;Diffusion;Disease Outbreaks;Drug Residues;drug use behavior;Educational Curriculum;Effectiveness;effectiveness outcome;effectiveness/implementation trial;empowerment;ethnic minority;Ethnic Population;Ethnography;Evaluation;evidence base;Feedback;Focus Groups;Future;Goals;Grant;Health;Health behavior change;Hepatitis C;Hepatitis C Prevalence;High Prevalence;HIV;HIV/HCV;implementation fidelity;implementation intervention;implementation strategy;Indiana;Injecting drug user;Injections;innovation;Intervention;intervention refinement;Interview;Knowledge;Learning;Massachusetts;Measures;meetings;member;Methods;Migrant;migration;Modeling;naloxone carriage;Needle Sharing;Neighborhoods;New York City;Nonmigrant;Not Hispanic or Latino;opioid overdose;Outcome Measure;outreach;Overdose;overdose death;overdose prevention;overdose risk;peer;peer influence;Pharmaceutical Preparations;Positioning Attribute;prevent;preventive intervention;Process;Protocols documentation;Puerto Rican;Puerto Rico;racial minority;Recommendation;Reporting;Research;Resources;response;Risk;Risk Behaviors;Risk Reduction;Role;Rural;rural area;Series;Services;Social Network;Sterility;Structure;surveillance study;syndemic;Syringes;theories;Time;Training;United States;urban area;Veins;Visual;Waiting Lists;Water

PROJECT_TITLE: Ending HIV and Taming HCV and Overdose Among Puerto Rican PWID in New York City: The Ganchero Intervention

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_CITY: DURHAM

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative RAS genes are mutated to remain in an active oncogenic state in one-fifth of all human cancers. The proposed study to identify novel intensity-specific regulators of oncogenic Ras signaling, and elucidate their roles during tumorigenesis has a direct relevance in a broad spectrum of human cancers. Hence, these regulators may predict the risk of KRAS-mutant cancers and could be leveraged as new therapeutic targets.

PI_NAMEs: KABIRI, ZAHRA  (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Biochemistry;biological adaptation to stress;Cancer Biology;Cancer cell line;cancer initiation;cancer therapy;candidate identification;Cells;clinically relevant;Codon Nucleotides;CRISPR/Cas technology;Disease;Drosophila genus;experience;Eye;Family;Family member;fascinate;Feedback;fly;Frequencies;gene discovery;Genes;Genetic;Genetic Predisposition to Disease;Genetically Engineered Mouse;Goals;Growth;Homologous Gene;Human;in vivo;knock-down;KRAS2 gene;Libraries;Link;Malignant Neoplasms;malignant phenotype;Mammalian Cell;MAP Kinase Gene;Maps;Mediating;Medicine;Messenger RNA;Monitor;Monomeric GTP-Binding Proteins;mRNA Stability;mRNA Translation;multidisciplinary;mutant;Mutate;Mutation;new therapeutic target;novel;novel strategies;novel therapeutics;Oncogenic;Output;Pathology;Pathway interactions;Phenotype;Positioning Attribute;Post-Transcriptional Regulation;Protein Subunits;Proteins;RAS driven cancer;RAS genes;ras Proteins;Regulation;Research;Research Personnel;response;Ribosomal Proteins;Ribosomes;risk prediction;RNA Interference;RNA-Binding Proteins;Role;screening;senescence;Signal Transduction;stem cell biology;Testing;Therapeutic Intervention;therapeutic target;therapy resistant;Time;Translations;tumor initiation;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;tumorigenesis;whole genome

PROJECT_TITLE: Identifying Novel Intensity-Specific Regulators of RAS Signaling


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Narrative This proposal aims to reveal how microcircuitry within a specific brain structure contributes to normal behavioral control, and how dysfunction of this structure results in abnormal behavior. Greater understanding of this circuitry would be of immense value in designing improved therapies for Parkinson's Disease, dystonias, Tourette Syndrome, and other serious brain disorders.

PI_NAMEs: BERKE, JOSHUA D (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Acetylcholine;Affect;Amphetamines;Behavior;Behavior Control;Behavioral;Bilateral;Bradykinesia;Brain;Brain Diseases;Calcium;Calcium Signaling;Cells;Cognitive;computer framework;Corpus striatum structure;Cues;Data;Decision Making;design;Dopamine;Dopaminergic Agents;Dorsal;Dystonia;Electrophysiology (science);Event;expectation;experimental study;Functional disorder;Gene Modified;Gilles de la Tourette syndrome;Goals;Human;improved;Individual;information processing;Infusion procedures;innovation;innovative technologies;insight;Interneurons;Investigation;Joints;Knowledge;Laboratories;Learning;Methods;Modeling;Monitor;Motor;Movement;Nervous System Disorder;Neurons;operation;optical fiber;Optics;optogenetics;Oxidopamine;Parkinson Disease;Parvalbumins;Pathway interactions;Pattern;Photometry;Play;Population;Process;programs;Psychological reinforcement;Rattus;Reaction Time;Recording of previous events;redshift;Research;reward anticipation;Rewards;Rodent Model;Role;sensor;Sensory;Shapes;Side;Signal Transduction;Slice;Somatostatin;Structure;temporal measurement;Testing;tool;Training;Vision

PROJECT_TITLE: Striatal Microcircuit Dynamics

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: COLUMBIA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Preeclampsia is the leading cause of maternal mortality worldwide. The proposed project will utilize three recently developed, highly innovative cell culture models to understand how the development of the placenta is disrupted in preeclampsia.

PI_NAMEs: ROBERTS, R. MICHAEL;SCHULZ, LAURA CLAMON (contact);SCHUST, DANNY J

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: 3-Dimensional;Address;Affect;Biological Models;blastocyst;BMP4;Cell Culture Techniques;Cell Line;Cell Nucleus;cell type;Cells;Characteristics;Conceptions;Conceptus;convict;Defect;Development;Disease;early experience;early onset;Embryo;Environment;Epigenetic Process;experience;Exposure to;Face;Failure;fetal;Fibroblasts;First Pregnancy Trimester;Genetic;Germ Cells;Giant Cells;Grouping;Heterogeneity;HLA G antigen;Human;Impairment;Implant;implantation;induced pluripotent stem cell;Infant;inhibitor;innovation;Invaded;Knowledge;Laboratories;Maternal Mortality;migration;Mitochondria;Modeling;Morbidity - disease rate;mortality;Mothers;Organoids;Oxidative Stress;Pathologic;pathophysiology of preeclampsia;Pathway interactions;Patients;Physiological;Placenta;Placenta Diseases;placental trophoblasts;Placentation;Population;Pre-Eclampsia;Predisposition;Pregnancy;Pregnancy loss;Production;Property;Protocols documentation;Reactive Oxygen Species;Role;Signal Transduction;Site;Source;Spiral Artery of the Endometrium;stem cell model;stem cell organoids;stem cells;Stress;Syncytiotrophoblast;Testing;transcriptome sequencing;transcriptomics;trophoblast;trophoblast stem cell;Umbilical cord structure;Uterus;Villous;Villus

PROJECT_TITLE: Modeling Normal and Abnormal Trophoblasts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-L(02)M]


ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: The overall goal of the study is to understand how DNA-dependent protein kinase (DNA-PK) suppresses genomic instability and prevents the malignant transformation of blood cells via its KU-dependent assembly and release on both DNA and RNA. Specifically, we will 1) analyze RNA vs DNA binding by KU and DNA-PK; 2) characterize the impact of acute KU-depletion on RNA metabolism, 3) the physiological functions of the C-terminal region (CTR) and tail of Ku80 in normal hematopoiesis and malignant transformation.

PI_NAMEs: ZHA, SHAN  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Acute;Affect;Alanine;Anemia;artemis;ataxia telangiectasia mutated protein;Binding;Biochemical;Biogenesis;Biological Assay;Blood Cells;Bone marrow failure;C-terminal;cancer cell;cancer clinical trial;cancer therapy;Catalytic Domain;Cell Cycle;Cells;Cellular biology;Chromosomal translocation;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Defect;Development;DNA;DNA Binding;DNA Double Strand Break;DNA Repair;DNA-dependent protein kinase;DNA-PKcs;Double Strand Break Repair;Double-Stranded RNA;ds-DNA;Embryo;endonuclease;Erythropoiesis;G22P1 gene;Gene Rearrangement;Genetic;Genetic study;Genomic Instability;Genomic Segment;genotoxicity;Goals;Hematopoiesis;Holoenzymes;Human;Human Cell Line;Impairment;In Vitro;in vivo;inhibitor;leukemia/lymphoma;Licensing;Ligation;live cell imaging;Lymphocyte;Lymphoma;Malignant - descriptor;Malignant Neoplasms;Mammals;Mediating;Molecular Conformation;mouse model;Mus;Myeloid Leukemia;N-terminal;Nonhomologous DNA End Joining;Oncogenic;Pathway interactions;Phase;Phosphorylation;Phosphotransferases;Physiological;preservation;prevent;Proliferating;protein kinase inhibitor;Proteins;recruit;Regulation;Ribosomal RNA;Ribosomes;RNA;RNA Binding;RNA metabolism;RNA Processing;Role;single molecule;single-molecule FRET;Small Nucleolar RNA;Stress;Structure;System;Tail;targeted cancer therapy;telomere;Testing;tool;Transfer RNA;Translations;Tumor Suppression;V(D)J Recombination;XRCC5 gene

PROJECT_TITLE: The role of DNA-PKcs in DNA repair, lymphocyte development, RNA metabolism and tumor suppression

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Mental Health;Primary Health Care;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Alcohol use disorder (AUD) is common and causes extensive morbidity and mortality and we have effective psychosocial treatments, in particular Cognitive Behavioral Therapies (CBT) and Motivational Interviewing (MI); however, less than 10% of patients with AUD receive treatment. Primary care is a critical setting for identifying patients with untreated AUD, but limited accessibility of specialty addiction treatment and other barriers prevent patients from initiating and receiving effective AUD treatment. This project aims to fill this gap by testing the impact of a novel telemedicine-delivered MI-CBT treatment intervention (MI-CBT TeleTx) compared to enhanced usual care (EUC) on AUD treatment utilization and alcohol-related outcomes among primary care patients with AUD.

PI_NAMEs: BONAR, ERIN E.;LIN, LEWEI ALLISON (contact)

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: Abstinence;addiction;Address;Adult;Alcohol consumption;alcohol effect;alcohol intervention;alcohol related consequences;alcohol risk;alcohol use disorder;alcohol-related death;Alcohols;care seeking;Caring;Cellular Phone;Chronic;Clinic;Clinical;Cognitive Therapy;comparison intervention;Consensus;COVID-19;COVID-19 pandemic;design;drinking;effective therapy;efficacy evaluation;efficacy trial;evidence base;Evidence based treatment;experience;follow-up;Functional impairment;functional improvement;Goals;Healthcare Systems;Heavy Drinking;Home;improved;Infrastructure;innovation;interest;Intervention;intervention effect;Location;Measures;Mediator;Medical;medical specialties;Mental disorders;Mental Health;Michigan;Modeling;Morbidity - disease rate;mortality;Motivation;motivational enhancement therapy;National Institute on Alcohol Abuse and Alcoholism;novel;Outcome;Participant;patient engagement;Patients;Persons;Population;prevent;Primary Care;primary care clinic;primary care patient;Provider;psychoeducation;psychosocial;Public Health;Quality of life;Randomized;Recommendation;Recovery;recruit;Risk;Science;screening, brief intervention, referral, and treatment;social stigma;Socioeconomic Status;Strategic Planning;Substance Use Disorder;Telemedicine;Testing;Therapeutic Intervention;treatment as usual;Videoconferencing;Work

PROJECT_TITLE: Harnessing telemedicine to improve alcohol use disorder outcomes in primary care patients

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Back Pain;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Chronic Pain;Clinical Research;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE / RELEVANCE Inquiry into the effects of long-term prescription opioid use in patients with chronic pain are highly relevant and timely due to the increased epidemic of prescription opioid use in the US. Using quantitative sensory testing, neuropsychological assessments, multimodal neuroimaging and advanced statistical techniques for data analysis, the proposed study seeks to identify the effects of long-term prescription opioid use on the brain and their relation to clinical symptoms. By detecting changes at behavioral, molecular and neural systems levels, this study will be pivotal in the development of effective pain management strategies in chronic pain, and training of Dr. Jarrahi as an independent investigator in the field of translational pain research.

PI_NAMEs: JARRAHI, BEHNAZ  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: abuse liability;addiction;Address;Affect;American;Amygdaloid structure;Anterior;Award;Behavior;Behavioral;Brain;brain circuitry;brain morphology;Caring;Chronic;Chronic low back pain;chronic pain;chronic pain patient;chronic painful condition;classification algorithm;Clinical;clinical application;Clinical Trials;Cognitive;cognitive control;cognitive function;cognitive performance;cognitive process;cohort;Corpus striatum structure;Data;Data Analyses;data modeling;Decision Making;Development;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;dopamine system;Drug usage;Epidemic;Epidemiologist;Epidemiology;Executive Dysfunction;executive function;experience;Faculty;flexibility;Functional Magnetic Resonance Imaging;Funding;Future;Goals;gray matter;Health;Hyperalgesia;Iatrogenesis;imaging scientist;Imaging Techniques;Infrastructure;innovation;Insula of Reil;Investigation;Link;Long-Term Effects;Machine Learning;machine learning classifier;Magnetic Resonance Imaging;Measures;Mediating;Medical;Mentors;Molecular;Morphology;MRI Scans;Multimodal Imaging;multimodal neuroimaging;National Institute of Drug Abuse;neural;neuroimaging;Neuropsychological Tests;Neuropsychology;neurotransmission;Nucleus Accumbens;Opiate Addiction;Opioid;Opioid Analgesics;opioid tapering;opioid therapy;opioid use;Pain;Pain management;Pain Measurement;pain patient;pain processing;Pain Research;patient oriented;Patient Self-Report;Patients;Pattern;Pharmaceutical Preparations;Play;Positron-Emission Tomography;Prefrontal Cortex;prescription opioid;Prevalence;Principal Investigator;Psyche structure;Psychophysics;Questionnaires;Raclopride;receptor binding;Recovery;recruit;Research;Research Personnel;Research Project Grants;Resolution;response;responsible research conduct;Rest;Rewards;risk mitigation;Role;Sensory;Short-Term Memory;skills;Societies;Specialist;Strategic Planning;Structure;Substance abuse problem;substance use;Substance Use Disorder;Symptoms;System;Techniques;Testing;Thick;Time;tool;Training

PROJECT_TITLE: Multivariate Machine Learning to Characterize Opioid-induced Alterations in the Brain in Chronic Pain

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Obesity;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Microtubule targeted agents (MTAs) are a mainstay in the treatment of breast and ovarian cancers; however, acquired resistance to these drugs remains a significant problem. In the proposed research, I will identify key determinants for the targeted use of MTAs for the treatment of ovarian cancer (F99 phase), and further employ mechanistically diverse MTAs to elucidate the molecular mechanisms of adipocyte-mediated resistance in ovarian cancer (K00 phase). The proposed F99/K00 training and research will determine mechanisms underlying taxane resistance and promote a more rational use of a class of mechanistically underappreciated drugs for the more effective treatment of women’s cancers.

PI_NAMEs: YEE, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: ABCB1 gene;Actins;Adipocytes;Adipose tissue;Agonist;anti-cancer;Antimitotic Agents;Arachidonic Acids;Area;Binding;Bioinformatics;Biological Markers;biomarker identification;Breast Cancer Model;Breast Cancer Treatment;Cancer Model;cancer pharmacology;Cancer Prognosis;cancer therapy;career;Chemoresistance;Chronic;Classification;Clinical;clinically relevant;Cytoskeletal Proteins;Cytoskeleton;Development;Diagnosis;diet-induced obesity;Disease;Disease Resistance;disorder risk;docetaxel;Drug Efflux;Drug resistance;effective therapy;efflux pump;Epidermal Growth Factor Receptor;Fellowship;Filament;follow-up;Future;Growth Factor;GTP-Binding Proteins;High Fat Diet;IL8 gene;improved;In Vitro;in vivo;Inflammation;Inflammatory;Injections;innovation;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Metabolic Diseases;Microtubules;Modeling;Molecular;Molecular and Cellular Biology;Mus;N-terminal;Neoplasm Metastasis;novel;novel therapeutics;Obesity;Omentum;Oncogenes;Oncogenic;optimal treatments;Paclitaxel;Patients;Peritoneum;Pharmaceutical Preparations;pharmacophore;Phase;Postdoctoral Fellow;pre-doctoral;Process;Production;Prognosis;Protein Isoforms;refractory cancer;relapse patients;Research;Research Personnel;Resistance;Resistance development;resistance mechanism;response;Signal Pathway;Signal Transduction;Solid Neoplasm;Specificity;Tacca;targeted agent;targeted delivery;targeted treatment;taxane;Testing;Therapeutic;Time;TLR4 gene;tool;trafficking;Training;tumor;tumor progression;Up-Regulation;Vinca Alkaloids;Woman;women's treatment

PROJECT_TITLE: Adipose tissue immunometabolism in ovarian cancer progression and chemoresistance


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Our goal is to support biomedical analysis of genome and epigenome data by developing faster and more accu- rate approaches to compare genomic interval sets.

PI_NAMEs: SHEFFIELD, NATHAN  (contact)

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TERMS: Address;Affect;Algorithms;Area;ATAC-seq;Automobile Driving;Binding;Biological;Biomedical Research;ChIP-seq;Chromosomes;Communities;Data;Data Set;Data Sources;Databases;design;Dimensions;Disease;Disease Outcome;DNA;Epigenetic Process;epigenome;epigenomics;experimental study;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic analysis;Genetic Annotation;Genetic Variation;Genome;genome analysis;Genomic Segment;Genomics;Goals;Health;Human;Human Genome;human reference genome;improved;Individual;innovation;Investments;Learning;Machine Learning;machine learning method;markov model;Measures;Methods;Natural Language Processing;novel;novel strategies;Outcome;Protocols documentation;Resources;scalable algorithms;Signal Transduction;Source;Speed;Structure;Techniques;Text;tool;trait;vector;Work

PROJECT_TITLE: Novel methods for large-scale genomic interval comparison

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Prevention;Vector-Borne Diseases

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative: The Epicenter for Emerging Infectious Disease Intelligence will establish research hubs in the Amazon and Congo Basin forest for emerging infectious disease research, building on our demonstrated commitment to capacity strengthening in these regions. Our proposed research will enhance surveillance for arboviruses and filoviruses in acute febrile illness cases, vectors, and vertebrate hosts that are perpetuating transmission in forest and urban systems. This work will advance an understanding of cross-species transmission dynamics for emerging viral threats, as well as optimize innovative and deployable surveillance and testing strategies to strengthen infectious disease surveillance and enable rapid response to outbreaks as part of the Emerging Infectious Disease Research Center network.

PI_NAMEs: BARKER, CHRISTOPHER M;COFFEY, LARK L;EVANS, TIERRA SMILEY;JOHNSON, CHRISTINE KREUDER (contact);MORRISON, AMY CELESTE

PROGRAM_OFFICER_NAME: WOODSON, SARA ELAINE

PROJECT_TERMS: Acute;acute infection;Animals;Arboviruses;Area;Chiroptera;Clinic;cohort;Collaborations;Communicable Diseases;Communities;Congo;Consensus;Country;Coupled;cross-species transmission;Culicidae;deep sequencing;Detection;Disease;disease model;Disease Outbreaks;Disease Surveillance;disease transmission;disorder risk;Early Diagnosis;Ecosystem;Emerging Communicable Diseases;emerging infectious disease evolution;emerging virus;Enrollment;Ensure;epidemiological model;Epidemiology;Ethics;Event;Evolution;experience;Fever;Filovirus;forest;global health;Goals;Government;Health;high risk;Human;Immunodiagnostics;improved;Infectious Disease Epidemiology;Infectious Diseases Research;Influenza;innovation;insight;Institution;integration site;Intelligence;International;Investigation;Medical Entomology;Methods;Microbiology;Modeling;Monitor;multidisciplinary;National Institute of Allergy and Infectious Disease;new pandemic;next generation;nonhuman primate;novel;outbreak concern;outbreak preparedness;outbreak response;pandemic potential;Pathogen detection;Peripheral;Persons;Peru;Pilot Projects;Predisposition;Readiness;Recording of previous events;Research;Research Activity;Research Priority;Resources;response;Rest;Reverse Transcriptase Polymerase Chain Reaction;Risk;RNA Viruses;Scientist;Seasons;Security;Serology;Site;Source;Surveillance Program;System;Techniques;Technology;Testing;Time;tool;transmission process;Uganda;urban setting;Urbanization;vector;vector-borne;Viral;viral transmission;virology;Virus;vulnerable community;Work;Zoonoses;zoonotic spillover

PROJECT_TITLE: EpiCenter for Emerging Infectious Disease Intelligence


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed research will evaluate the implementation and effectiveness of HIV testing and prevention services in community pharmacies to increase HIV testing access and prevent delayed HIV diagnosis that results in higher community transmission and poorer treatment outcomes. Successful development of this model could establish pharmacies as a sustainable, HIV prevention source, particularly for populations with lower access to HIV prevention resources.

PI_NAMEs: CRAWFORD, NATALIE D. (contact)

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Adopted;Adoption;AIDS prevention;American;Attitude;Blood Pressure;Cholesterol;Client;community collaboration;community engagement;Community Pharmacy;Community Surveys;community transmission;Consolidated Framework for Implementation Research;Counseling;COVID-19;Development;Effectiveness;effectiveness outcome;effectiveness testing;effectiveness/implementation study;Engineering;Epidemic;experience;Exploration, Preparation, Implementation, and Sustainment;Glucose;Goals;Health;health care availability;high risk population;HIV;HIV diagnosis;HIV Infections;HIV risk;HIV Seronegativity;HIV Seropositivity;Human immunodeficiency virus test;hybrid type 1 design;hybrid type 1 study;Hybrids;implementation evaluation;implementation outcomes;implementation science;Individual;Infection;Interview;Knowledge;member;Methodology;Methods;model development;Modeling;multidisciplinary;Neighborhoods;online community;patient safety;Persons;Pharmacy facility;Phase;phase 3 study;Policies;Population;pre-exposure prophylaxis;Preparation;Prevalence;prevent;Prevention;prevention service;Primary Prevention;Readiness;Reporting;Research;Research Design;Resources;Risk Reduction;scale up;screening;Self Efficacy;service delivery;Service provision;service uptake;Services;social stigma;Source;Stigmatization;System;Testing;testing access;testing services;testing uptake;Training;transmission process;Treatment outcome;United States;Variant;Viral Load result;virtual;willingness;Work

PROJECT_TITLE: Strengthening the HIV prevention continuum using pharmacies


PHR: PROJECT NARRATIVE Pulmonary arterial hypertension (PAH) is a progressive vascular disease with high morbidity and mortality. Type 2 BMP receptor (BMPR2) mutations are the commonest genetic causes of PAH. This application aims to elucidate the molecular mechanism of activation of BMPR2 and its downstream signaling pathway, which is critical for the maintenance of the healthy pulmonary vasculature and mitigating PAH.

PI_NAMEs: HATA, AKIKO  (contact);JURA, NATALIA

PROJECT_TERMS: Activin Receptor;activin receptor-like kinase 1;ACVR1 gene;ACVRL1 gene;Binding;Biological Assay;Biophysics;Blood Vessels;BMP2 gene;Bone Morphogenetic Protein Receptor Gene;bone morphogenetic protein receptors;C-terminal;Catalytic Domain;Cell Nucleus;Cells;Cessation of life;Complex;Cryoelectron Microscopy;Deuterium;Development;Disease;Distal;extracellular;Family;Gene Mutation;Gene Structure;Genes;Genetic;Goals;Heritability;Heterozygote;Homeostasis;Hydrogen;In Vitro;innovation;insight;interdisciplinary approach;Investigation;Knowledge;Length;Ligand Binding;Ligand Binding Domain;Ligands;Light;Link;Lung;lung microvascular endothelial cells;Maintenance;Maps;Mass Spectrum Analysis;Measures;member;Membrane;Membrane Biology;Methods;Modeling;Molecular;Molecular Conformation;Morbidity - disease rate;mortality;Mutagenesis;mutant;Mutation;novel;novel therapeutics;Pathogenesis;Pathogenicity;Pathologic;Patients;Phosphorylation;Phosphotransferases;Physiological;primary pulmonary hypertension;Progressive Disease;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary arterial remodeling;Pulmonary artery structure;receptor;Receptor Activation;Receptor Gene;Receptor Serine/Threonine Kinase;Receptor Signaling;reconstitution;Regulation;Research;right ventricular failure;Rodent;Roentgen Rays;Role;Signal Pathway;Signal Transduction;Site;Smad Proteins;stem;structural biology;Structural Models;Structure;success;Tail;targeted treatment;Time;Transforming Growth Factor beta;Transmembrane Domain;Variant;Vascular Diseases;Work;X-Ray Crystallography

PROJECT_TITLE: Elucidating the structural insights into the BMP receptor mutations in PAH


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Underserved, racial and ethnic minority communities are experiencing higher rates of COVID-19 cases and associated mortality compared to whites due to long standing social and structural inequities that also drive disparities in chronic diseases such as stroke, cardiovascular disease, diabetes, and hypertension. Patients with underlying chronic diseases who are recovering from COVID-19 depend on the support of family caregivers who are being exposed to the same pandemic and racial stressors, exposure that can affect the health and quality of life of both partners. The primary goal of this study is to test the efficacy of an adapted, telehealth-enhanced intervention that targets barriers impacting family illness management behaviors of survivor:carepartner dyads for improved quality of life and COVID-19/chronic disease related health outcomes.

PI_NAMEs: MAGWOOD, GAYENELL SMITH (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: 2019-nCoV;Address;Adult;Affect;African American;Age;Anxiety;arm;attentional control;barrier to care;Behavior;Behavioral;Cardiovascular Diseases;care delivery;Caring;Chronic;Chronic Disease;Chronic Kidney Failure;Communities;Community Health Aides;community intervention;comorbidity;contextual factors;COVID-19;COVID-19 impact;COVID-19 morbidity;COVID-19 mortality;COVID-19 pandemic;COVID-19 risk;COVID-19 survivors;Death Rate;design;Diabetes Mellitus;Discrimination;disorder risk;Disparity;Economically Deprived Population;efficacy testing;Environment;ethnic minority;experience;Exposure to;Family;Family Caregiver;Family Relationship;family support;Fatigue;Focus Groups;Future;Goals;Health;Health Benefit;health care availability;health inequalities;Health Personnel;Health Promotion;Health Status;Healthcare Systems;high risk;Hospitalization;Hypertension;Impairment;improved;Individual;Inequity;informal care;Information Management;innovation;Institutional Racism;intersectionality;Intervention;intervention effect;Interview;Linear Models;Link;Literature;Measures;Mental Health;Methods;Minority;minority communities;Minority Groups;minority health;minority patient;Modeling;mortality;Nurses;Older Population;Outcome;Pain interference;pandemic disease;pandemic impact;pandemic stressor;Patient Care;Patients;Pattern;people of color;PhenX Toolkit;physical conditioning;preference;pressure;psychosocial;Psychosocial Factor;Public Health;public health emergency;Qualitative Methods;Quality of life;Race;racial minority;racism;Recovery;Reduce health disparities;Research;Risk;risk mitigation;Role;rural area;SARS-CoV-2 infection;secondary outcome;Self Efficacy;Self Management;Sick Role;social;social determinants;Social Environment;social health determinants;Social Identification;Social status;Social support;social vulnerability;sociodemographic factors;socioeconomic disadvantage;Stress;stressor;Stroke;stroke patient;structural determinants;structural health determinants;Survivors;Symptoms;System;telehealth;Testing;theories;therapy design;Trauma;trauma exposure;Treatment Efficacy;underserved community;underserved minority;Underserved Population

PROJECT_TITLE: Improving the Collaborative Health of Minority COVID-19 Survivor & Carepartner Dyads Through Interventions Targeting Social and Structural Health Inequities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(58)R]


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: A major challenge for treatment of non-small cell lung cancer (NSCLC) is the presence or emergence of therapeutic resistance to receptor tyrosine kinase (RTK) inhibitors. We have identified a new approach for targeting cell surface glycoprotein receptors (such as RTKs) through inhibition of the oligosaccharyltransferase (OST). To advance this therapeutic strategy the proposed research will characterize and test OST inhibitors in genetically defined subgroups of NSCLC to identify mechanisms of drug sensitivity as well as novel inhibitors with the potential for clinical translation.

PI_NAMEs: CONTESSA, JOSEPH N (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Address;analog;Animal Model;Apoptosis;Asparagine;Biological Models;Bypass;cancer subtypes;cancer survival;cancer therapy;Catalytic Domain;Cell Cycle Arrest;cell killing;Cell Proliferation;Cell Surface Proteins;Cell Survival;Cells;Chemicals;Clinic;clinical translation;Clinical Trials;combinatorial;Combined Modality Therapy;Complex;Coupled;Couples;Data;Death Rate;design;Diagnosis;Disease;drug development;drug discovery;Drug Kinetics;drug sensitivity;efficacy testing;Endoplasmic Reticulum;Epidermal Growth Factor Receptor;epithelial to mesenchymal transition;experimental study;FGFR1 gene;Fluorescence;Gene Amplification;gene product;Glycoproteins;glycosylation;Goals;high throughput screening;Immune;immune checkpoint;Immune checkpoint inhibitor;improved;In Vitro;in vivo;in vivo evaluation;Individual;inhibitor;KRAS2 gene;Lead;Link;lung cancer cell;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Membrane Glycoproteins;Modality;Molecular;Morbidity - disease rate;Morphology;mortality;mutant;Mutation;neoplastic cell;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;novel;novel strategies;novel therapeutics;Oncogenic;overexpression;Pathway interactions;Patient-Focused Outcomes;Pharmaceutical Chemistry;pharmacologic;Polysaccharides;Post-Translational Protein Processing;Prevention;Process;programs;Property;Protein Complex Subunit;Protein Overexpression;Proteins;Radiation therapy;Radiation Tolerance;receptor;Receptor Activation;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Research;Resistance;senescence;Series;Signal Pathway;Signal Transduction;Site;small molecule;small molecule inhibitor;Specificity;Subgroup;Systemic Therapy;Testing;Therapeutic;therapeutic development;Therapeutic Effect;therapy resistant;Toxic effect;Translating;Translations;Treatment Efficacy;treatment strategy;tumor;tumor growth;tumor xenograft;Tyrosine Kinase Inhibitor;United States;Work

PROJECT_TITLE: OST Inhibition in NSCLC

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Genetics;Osteoporosis

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: This research will investigate how a protein hormone (parathyroid hormone, PTH) is able to interact with the surface of a cell in bone and transmit signals to the cell's DNA to regulate the expression of genes involved in bone breakdown. PTH is essential for maintaining serum calcium levels, but too much of the hormone or genetic diseases that act like PTH can cause major bone loss and disabilities. The results of our research will help develop treatments for hyperparathyroidism and other bone and skeletal disorders in place of surgery.

PI_NAMEs: PARTRIDGE, NICOLA C (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Adult;Binding;Biological Assay;bone;Bone Development;Bone Diseases;bone loss;Bone Resorption;bZIP Domain;Calcium;calcium metabolism;Calcium Metabolism Disorders;Catabolism;Cell Nucleus;Cells;chromatin immunoprecipitation;Chronic Kidney Failure;Co-Immunoprecipitations;Continuous Infusion;CREB1 gene;Cyclic AMP;Cyclic AMP Response Element;Cyclic AMP-Dependent Protein Kinases;Cytoplasm;Data;Development;disability;Disease;Distal;DNA;G-Protein-Coupled Receptors;Gene Expression;Genes;Genetic Diseases;Genetic Transcription;Goals;Grant;Homeostasis;hormone regulation;Hormone Responsive;Hormones;Hyperparathyroidism;Immunofluorescence Immunologic;in vivo;Individual;interest;knock-down;Knowledge;Mass Spectrum Analysis;McCune-Albright Syndrome;Mediator;Messenger RNA;Metaphyseal chondrodysplasia;Molecular;Mus;novel;Nuclear;Nuclear Accidents;Nuclear Translocation;Operative Surgical Procedures;Osteoblasts;Osteoclasts;Osteoporosis;parathyroid hormone (1-34);Pathway interactions;peptide analog;Phosphoric Monoester Hydrolases;Phosphorylation;Physiological;Play;Population;Protein Dephosphorylation;protein expression;Protein phosphatase;Protein Serine/Threonine Phosphatase;Proteins;Proteomics;prototype;PTH gene;Quantitative Reverse Transcriptase PCR;Regulation;Research;response;Role;salt-inducible kinase;scaffold;Series;Serum Calcium Level;Serum Markers;Signal Transduction;Site;skeletal;skeletal disorder;Skeleton;Small Interfering RNA;Surface;Testing;Time;TRANCE protein;Transcription Coactivator;transcription factor;transmission process;Work

PROJECT_TITLE: Nuclear Events in PTHR1 Action on Bone


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Pediatric;Prevention;Unintentional Childhood Injury

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: 1 Project Narrative Each year, more than a quarter of a million U.S. infants and children suffer critical illness and receive intensive care yet little is known about their long-term recovery. The objective of this study is to learn about pediatric recovery from critical illness to guide future intervention research to optimize child and family health. 1

PI_NAMEs: CURLEY, MARTHA AQ (contact);WATSON, R SCOTT

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Acute;Address;Adult;Affect;Age;Caring;Characteristics;Child;Child Health;Childhood;Chronically Ill;Cognitive;congenital heart abnormality;Continuity of Patient Care;Control Groups;Critical Care;Critical Illness;Data;design;Disease;Emotional;emotional experience;Enrollment;Exhibits;experience;Family;Family health status;Frequencies;functional status;Future;Gender;Goals;Health;health related quality of life;Health Status;Heterogeneity;Hospitalization;Hospitals;Impaired cognition;Impairment;improved;Infant;Intensive Care;Intensive Care Units;Interdisciplinary Study;Intervention;Intervention Studies;Knowledge;Learning;long term recovery;Longitudinal cohort study;Medical;Mental Health;mental state;Mission;modifiable risk;Morbidity - disease rate;mortality;National Institute of Child Health and Human Development;Outcome;Outcome Assessment;Parents;patient population;Patients;Pediatric cohort;Pediatric Intensive Care Units;pediatric trauma;Pediatrics;Pennsylvania;Personal Satisfaction;physical impairment;Population;prevent;programs;prospective;psychological trauma;Publishing;Quality of life;Recovery;Rehabilitation therapy;Research;Research Institute;Risk;Risk Factors;Siblings;social;Social outcome;Social Problems;sociodemographics;Strategic Planning;Subgroup;Survivors;Syndrome;Testing;Time;Traumatic injury;Universities;Well in self

PROJECT_TITLE: Post-Intensive Care Syndrome Pediatrics, Longitudinal Cohort study

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE This study is based on our recent findings that the expression of FoxO transcription factors is suppressed in articular cartilage from aged and osteoarthritis-affected human and mouse joints. The proposed research will investigate the role of FoxO in joint homeostasis, consequences of FoxO suppression in joint aging and osteoarthritis pathogenesis and determine potential therapeutic benefits of increasing FoxO expression. The findings from this work have potential to lead to a paradigm shift in the understanding of the impact of joint aging on osteoarthritis pathogenesis and lead to new approaches to prevention and treatment. !

PI_NAMEs: LOTZ, MARTIN K (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Abnormal Cell;Acceleration;Affect;age related;aged;Aging;aging related;Apoptosis;arthropathies;articular cartilage;Autophagocytosis;Cartilage;cartilage degradation;Cell Aging;Cell Death;Cells;Cessation of life;ChIP-seq;Chondrocytes;Data Analyses;Data Set;Degenerative polyarthritis;Elements;Equilibrium;Event;extracellular;Extracellular Matrix;Extracellular Matrix Degradation;Failure;Foundations;FOXO1A gene;FOXO3A gene;Gatekeeping;Genes;Growth;Histones;Homeostasis;Human;Impairment;In Vitro;in vitro Model;Injury;Joints;knock-down;Knockout Mice;Maintenance;Mediator;Molecular;mRNA Expression;Mus;novel;novel strategies;Operative Surgical Procedures;Outcome;overexpression;Oxidants;Pathogenesis;Pathway interactions;pharmacologic;postnatal;prevent;Prevention approach;Process;promoter;protective effect;protein expression;Proteins;Regulation;Reporting;Research;Risk Factors;Role;Severities;Severity of illness;Signal Transduction;Sirolimus;Surgical Models;Testing;Therapeutic;Tissues;transcription factor;transcriptome sequencing;Work

PROJECT_TITLE: FoxO transcription factors in joint aging and osteoarthritis pathogenesis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Rare Diseases;Tuberculosis

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: PROJECT NARRATIVE Tuberculous meningitis (TBM) is the most devastating form of childhood tuberculosis, with much of the damage caused by infarction, the pathogenesis of which is poorly understood. We will recruit a cohort of children with probable or confirmed TBM and will use advanced molecular, proteomic and neuroimaging techniques to better understand the pathophysiology of infarction in TBM. We will then use computer simulation to evaluate the impact of different therapeutics, with the aim of developing a more targeted approaches to therapy.

PI_NAMEs: SEDDON, JAMES ALEXANDER (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Acute;Address;Affect;Anatomy;Anticoagulants;Area;Artificial Intelligence;Bioinformatics;Biological;Biology;Blood;Blood specimen;Blood Vessels;Brain;brain dysfunction;Brain Injuries;Cerebral Infarction;Cerebral Ischemia;cerebral oxygenation;Cerebrospinal Fluid;Cessation of life;Characteristics;Child;Childhood;Clinical;clinical epidemiology;Clinical Research;Coagulation Process;cohort;Computer Simulation;Data;Development;Diagnosis;differential expression;Disease;endothelial dysfunction;Endothelium;Evolution;experience;fluorodeoxyglucose positron emission tomography;follow-up;Functional disorder;Future;Gene Expression;Genes;Goals;Image;Immunoassay;improved;Infarction;Inflammation;Inflammatory;insight;Ischemia;Ischemic Penumbra;Laboratories;Left;Machine Learning;Magnetic Resonance Imaging;Mass Spectrum Analysis;Measures;Meningeal Tuberculosis;Methods;Molecular;Morbidity - disease rate;mortality;multidisciplinary;multiple omics;neglect;Neurodevelopmental Deficit;neuroimaging;Neurologic;Neurological disability;Neurosciences;Outcome;Pathogenesis;Pathogenicity;Pathologic Processes;Pathway interactions;PET/CT scan;Phenotype;Plasma;point of care testing;Population;predictive modeling;Probability;Process;prospective;protein profiling;Proteins;Proteomics;Public Health;Radiologic Finding;Radiology Specialty;radiomics;recruit;Research;Research Infrastructure;response;RNA;Sampling;South Africa;study population;Survivors;targeted treatment;Techniques;Therapeutic;Therapeutic Intervention;Thrombosis;thrombotic;Time;Tissues;transcriptome sequencing;transcriptomics;treatment stratification;Tuberculosis;Vasculitis;Work

PROJECT_TITLE: Understanding ischemia in children with tuberculous meningitis (iThemba)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-B(02)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE (RELEVANCE)  This project will construct models of gene regulatory networks controlling early human development by taking an integrative approach involving perturbation of core regulatory network elements, quantitative genomic and proteomic measurements with high temporal and single-cell resolution, and systems level analyses. Knowledge gained from the study will provide a conceptual framework for dissecting gene regulatory networks during cell state transitions, and reveal general features of genomic variants that contribute to cellular and organismal phenotypes.

PI_NAMEs: BEER, MICHAEL A;HADJANTONAKIS, ANNA-KATERINA ;HUANGFU, DANWEI  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: 3-Dimensional;Adult;algorithmic methodologies;ATAC-seq;Atlases;Attention;Back;Binding Sites;Biological Assay;Biological Models;Cell Fate Control;Cell model;Cell Physiology;cell type;Cells;ChIP-seq;Chromatin Conformation Capture and Sequencing;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Computing Methodologies;CRISPR interference;CRISPR screen;Data;Data Set;design;Development;Developmental Biology;Disease;DNA Computations;DNA Sequence Analysis;Ectoderm;Elements;Embryo;Embryonic Development;Emerging Technologies;Endoderm;Enhancers;Epiblast;functional genomics;Gene Expression;gene regulatory network;Generations;Genes;Genetic;genetic variant;genome-wide;genomic variation;Genomics;Germ Cells;Germ Layers;Goals;Health;Hi-C;Histones;Homeostasis;Human;Human Development;human embryonic stem cell;improved;Individual;innovation;Knowledge;Learning;Machine Learning;Maintenance;Malignant Neoplasms;Maps;Mass Spectrum Analysis;mathematical model;Measurement;Mesoderm;Modeling;multimodality;Mus;Natural regeneration;network models;Neuroectoderm;Organoids;Pathologic;Pathway Analysis;Peripheral;Phenotype;Physiological;pluripotency;predictive modeling;Proteins;Proteomics;Publishing;Records;Regulatory Element;Research Personnel;Resolution;Role;screening;self-renewal;Sequence Analysis;Signal Transduction;single cell genomics;single-cell RNA sequencing;Somatic Cell;stem cell biology;stem cell differentiation;System;Systems Biology;temporal measurement;Testing;Tissues;transcription factor;transcriptome sequencing;Variant;Work

PROJECT_TITLE: Genomic control of gene regulatory networks governing early human lineage decisions


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Digestive Diseases;Digestive Diseases - (Gallbladder);Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: CLIFTON PARK

ORG_NAME: KITWARE, INC.

PHR: Project Narrative Virtual simulators are powerful tools for training surgeons in skill-intensive minimally invasive procedures, however, to date most available simulators focus mainly on new surgeons in formal training programs, including medical students and surgery residents. There is a recognized need to support training and maintenance of skills for practicing surgeons. The goal of this project is to design, develop and evaluate open source software templates to train, retrain and advance performance of practicing surgeons to improve patient safety and healthcare outcomes.

PI_NAMEs: ENQUOBAHRIE, ANDINET ASMAMAW (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Academic Medical Centers;Adopted;Adverse event;Algorithms;Anatomy;bile duct;care outcomes;care providers;Child;Cholecystectomy;clinical application;Clinical Research;Collaborations;Communities;Computer software;continuing medical education;design;Development;Engineering;Ensure;Equipment;Equipment Malfunction;Evaluation;Event;experience;Face;Feedback;Funding Opportunities;Goals;heat injury;Hemorrhage;Hospitals;improved;Injury;innovation;Laparoscopic Cholecystectomy;Laparoscopic Surgical Procedures;Learning;Learning Skill;Maintenance;Medical;Medical center;medical schools;Medical Students;Methodology;Methods;minimally invasive;Minor;Modeling;New York;open source;open source tool;Operative Surgical Procedures;orthognathic;Outcome Assessment;Patient Care;patient safety;Patients;Performance;Physics;physiologic model;Physiologic pulse;Physiological;Physiology;Procedures;prototype;Puncture procedure;Regimen;Research Institute;resilience;response;Science;simulation;skill acquisition;skills;software development;Surgeon;Surgical Error;Techniques;Technology;technology development;Testing;Time;tool;Training;Training and Education;Training Programs;Training Support;Universities;Validation;Variant;virtual;virtual reality simulator;virtual surgery;Visualization;Work

PROJECT_TITLE: Surgical Simulator for Improving Skill Proficiency and Resilience

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CAMBRIDGE

ORG_DEPT: CHEMISTRY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project Narrative Alzheimer’s disease is a devastating neurodegenerative disease of aging which poses a massive burden on the health care system but for which there is currently no effective therapy or cure. Accumulating evidence suggests that targeting microglia could be beneficial in slowing disease progression, and our labs have discovered a novel microglial drug target called PU.1, that, when reduced in humans, significantly delays the age of onset of the disease. Therefore, we propose development of a drug discovery program aimed at safely reducing PU.1 activity, restoring beneficial microglial function and ultimately slowing the progression of Alzheimer’s disease.

PI_NAMEs: GOATE, ALISON M;RAY, WILLIAM J;TSAI, LI-HUEI  (contact)

PROGRAM_OFFICER_NAME: REFOLO, LORENZO

PROJECT_TERMS: Adopted;Affect;Age;Age of Onset;Aging;aging related disease;Agreement;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease therapeutic;Amyloid beta-Protein;Animals;Basic Science;Binding Proteins;Biological Assay;Biological Markers;Biology;biomarker development;biomarker identification;bone marrow hyperplasia;Brain;Canis familiaris;Cell Line;Cell Physiology;Cells;Chemistry;ChIP-seq;Clinical;Collaborations;combat;counterscreen;Data;Development;Disease;Disease Progression;Disease susceptibility;drug development;drug discovery;Drug Industry;Drug Targeting;effective therapy;efficacy evaluation;Failure;Future;Gene Expression;Genes;Genetic;Genetic study;Genetic Transcription;genome wide association study;genotoxicity;Goals;Haplotypes;Healthcare Systems;Human;Human Genetics;human genomics;human induced pluripotent stem cells;Immune;Immunoprecipitation;in vivo;induced pluripotent stem cell;Innate Immune System;innovation;Lead;lead optimization;Macrophage;Mass Spectrum Analysis;Measurement;Mediation;medical schools;Microglia;Microsomes;Modeling;Modification;Molecular and Cellular Biology;Molecular Target;mouse model;Mus;Myeloid Cells;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;neuroinflammation;No-Observed-Adverse-Effect Level;novel;novel therapeutics;Onset of illness;Peripheral;Peripheral Blood Mononuclear Cell;Permeability;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;phase 1 study;Phase III Clinical Trials;Plasma;Populations at Risk;Post-Translational Protein Processing;preclinical development;preclinical study;Prevalence;Primates;programs;proto-oncogene protein Spi-1;rational design;Rattus;Research Personnel;Risk Reduction;risk variant;Role;Route;Safety;safety study;scale up;screening;Sentinel;Series;small molecule;small molecule therapeutics;SPI1 gene;Structure;Technology;Testing;Tissues;tool;Toxicology;transcriptome sequencing;transcriptomics;University of Texas M D Anderson Cancer Center;Validation;Veterans;Wild Type Mouse

PROJECT_TITLE: Development of PU.1 Inhibitory Modulators as Novel Therapeutics for Alzheimer's Disease


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Maternal Health;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

PHR: NARRATIVE Structural racism and discrimination (SRD) among African Americans has remained a historical legacy of the United States and the resulting trauma can modify physiologic function and be transmitted to subsequent generations. The proposed study seeks to investigate the impact of race and transgenerational SRD-related trauma among AA women on distinct epigenetic modifications at the maternal-fetal interface that are linked to altered immune cell development, activation, and signaling in the placenta and developing fetus. Results from these studies may inform future interventions to address health disparities among at-risk mother-infant pairs and can promote their overall health and well-being.

PI_NAMEs: CHAKRABORTY, RANA ;JOHNSON, ERICA L (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Accounting;Address;Adult;adverse outcome;African;African American;African American population;African American Women;African ancestry;Awareness;Biological;Biological Markers;bisulfite sequencing;Black race;caucasian American;Cells;Child;Childhood;Chromatin Structure;Chronic;Civil Rights;cohort;comparative;Crows;cytokine;Death Rate;Development;digital;Discrimination;Disparity;Education;Environment;Epigenetic Process;experience;Exposure to;fetal;Fetal Development;Fetal Growth Retardation;fetal immunity;Fetus;Future;Gene Expression;Generations;genetic signature;Genetic Transcription;genome-wide;Genomic DNA;genomic platform;Germ Lines;Health;health disparity;Health Promotion;Immune;immune activation;Immune response;Immune System Diseases;Immunity;Immunologics;immunoregulation;in utero;infancy;Infant;Infant Health;infant morbidity;infant morbidity/mortality;Infant Mortality;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Inheritance Patterns;Inherited;Intervention;Link;Maternal Health;maternal stress;Maternal-Fetal Exchange;Modification;Mononuclear;Mothers;multiple omics;nano-string;neonate;Pathology;Pattern;perceived stress;Personal Satisfaction;Phenotype;Physiological;Placenta;Placentation;Population;Pre-Eclampsia;Pregnancy;Pregnancy Outcome;Pregnant Women;Premature Birth;Property;Race;racial disparity;response;Risk;Shapes;Signal Transduction;single-cell RNA sequencing;Socioeconomic Status;Standardization;Stress;Structural Racism;Surveys;systemic inflammatory response;Tissues;Training;transcriptome;transcriptome sequencing;transcriptomics;transgenerational epigenetic inheritance;transmission process;Trauma;Umbilical Cord Blood;United States;Vision;Voting Right;whole genome

PROJECT_TITLE: The Impact of Transgenerational Racial Trauma on Epigenetic Modifications in the Mother-Infant Dyad during Pregnancy. Comparisons Between Caucasian and African American Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-G(55)]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Congenital Structural Anomalies;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because a better understanding of the neurobiology underlying intellectual disability will lead to improved methods for prevention and treatment. The proposed research is relevant to the part of the NICHD's mission that pertains to developing interdisciplinary studies investigating the cellular and genetic factors that contribute to intellectual and developmental disabilities.

PI_NAMEs: DE RUBEIS, SILVIA  (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Ablation;Accounting;Address;Adult;Affect;Affinity Chromatography;Anxiety;autism spectrum disorder;Awareness;Behavior;behavior test;Behavioral;behavioral outcome;behavioral phenotyping;Biochemistry;Body Weight;Brain;brain malformation;Cell model;Cell Physiology;clinical phenotype;clinical sequencing;Cognitive;Cognitive deficits;Corpus Callosum;Cortical Malformation;Data;Defect;Development;Developmental Biology;Developmental Delay Disorders;Disease;disorder risk;Electroporation;Female;Functional disorder;Genes;Genetic;Genetic Diseases;Goals;Health;human tissue;Hyperactivity;improved;in utero;in vivo;Individual;innovation;Intellectual functioning disability;Interdisciplinary Study;Laboratories;Link;Literature;loss of function mutation;male;Maps;Measures;Messenger RNA;Methods;Microgyria;Missense Mutation;Mission;Molecular;Molecular Target;Motor;motor behavior;motor deficit;mouse model;Movement Disorders;mRNA Translation;Mus;Muscle hypotonia;Mutant Strains Mice;Mutation;National Institute of Child Health and Human Development;nerve stem cell;Neurobiology;Neurodevelopmental Disorder;neurogenesis;Neurons;Neurosciences;new therapeutic target;novel;novel therapeutic intervention;Pathogenicity;Pharmacological Treatment;Phenotype;Population;Preclinical Testing;Prevention;Problem behavior;Process;Prosencephalon;Protein Truncation;Public Health;Reporting;Research;Ribosomes;RNA Helicase;Sensory;social;Social Behavior;social deficits;Standardization;Syndrome;targeted treatment;Testing;Therapeutic;therapeutically effective;Translating;translatome;Validation;Viral;X Inactivation

PROJECT_TITLE: Cellular and molecular determinants of DDX3X syndrome

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposed project will help reduce the prevalence of bullying perpetration, victimization, and witnessing and improve the general bullying climate, sense of safety, responses to bullying (ie, positive bystander actions by students and more positive responding by teachers) as well as student-teacher and student relationships through the intermediate outcomes of teachers’ improved ability to detect, prevent, and intervene with bullying and peer conflicts in the classroom. The BCCU is a bullying prevention program that includes professional developmental and coaching that leverages motivational interviewing to empower teachers to engage in practice changes and mixed-reality simulation for guided practice of new skills. Together, the BCCU components addresses knowledge, attitudes, and skills of teachers to intervene with students who are directly involved (eg, victims, perpetrators) and indirectly involved (eg, bystanders/witnesses) in bullying, including foundational classroom management that integrates social-behavioral expectations, how to identify bullying behaviors in the classroom, and how to select and implement evidence-based strategies to address and intervene with these behaviors in real-time.

PI_NAMEs: PAS, ELISE TOURIS (contact);WAASDORP, TRACY EVIAN

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Academic achievement;acceptability and feasibility;Address;Adult;Aggressive behavior;Area;Attitude;Baltimore;Behavior;Behavioral;bullying;bullying prevention;checkup examination;Child;Child Behavior;Childhood;Climate;Competence;Data;Data Reporting;design;Detection;Development;Distal;effective intervention;efficacy testing;elementary school;Emotional;Empathy;empowerment;evidence base;expectation;experience;fifth grade;follow-up;Funding;Future Teacher;Grant;Health;High Prevalence;Hour;improved;Influentials;innovation;interest;Intervention;junior high school;Justice;Knowledge;Laws;Mediating;Mental Health;mixed reality;Modeling;motivational enhancement therapy;Outcome;peer;Perception;perpetrators;perspective taking;Philadelphia;pilot trial;Play;Practice Management;Prevalence;prevent;Prevention;Prevention program;Prevention strategy;Preventive;Professional counselor;Public Health;Randomized;randomized trial;Randomized, Controlled Trials;Reporting;response;Role;Safety;Sampling;School-Age Population;Schools;Self Efficacy;Self Perception;Shapes;simulation;Site;skills;social;Social Development;Students;teacher;Teacher Professional Development;Testing;Time;Training;Victimization;Well in self;Youth

PROJECT_TITLE: Coaching Teachers in Bullying Detection and Intervention

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Neurosciences;Opioids;Pain Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE  The central nervous system has an intrinsic pain modulatory system that regulates nociceptive processing through descending projections from the ventrolateral periaqueductal gray (vlPAG) to the rostral ventromedial medulla (RVM) that are relayed to the dorsal horn of the spinal cord. This circuit inhibits pain normally but can shift to facilitate pain contributing to persistent pain states. The studies in this proposal will map and define the circuit by identifying relevant PAG neurons and their connections with the RVM and examine the underlying cellular mechanisms responsible for the shift from inhibition to facilitation of pain.

PI_NAMEs: HEINRICHER, MARY MAGDALEN;INGRAM, SUSAN L (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Absence of pain sensation;Acute Pain;Adult;antinociception;Area;Automobile Driving;Behavior;Behavioral;Brain;Brain Stem;cell type;Cells;Central Nervous System;chronic pain;Complement;Complex;Development;dorsal horn;Electrophysiology (science);Equilibrium;experimental study;Freund's Adjuvant;Goals;Heterogeneity;Hyperalgesia;In Vitro;in vivo;Inflammation;Inflammatory;Injections;insight;Label;Laboratories;Link;Maps;Maternal Behavior;Measures;Mediating;midbrain central gray substance;Molecular;mu opioid receptors;Neurons;neurotransmitter release;Nociception;Opioid;Opioid Analgesics;optogenetics;Output;Pain;pain behavior;pain inhibition;Pain management;Pathway interactions;Peripheral;Persistent pain;pharmacologic;Physiological;Population;Property;Rattus;recruit;Reproduction;response;Role;sensory integration;Slice;Spinal cord posterior horn;Stress;Synapses;Synaptic plasticity;System;Testing;transmission process;Viral;Work

PROJECT_TITLE: Defining the descending pain modulatory circuit


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Improving adherence to physical activity (PA) programs is critical for overweight midlife adults (ages 50-64) in order to enhance weight management efforts and reduce risk of chronic disease and premature death. Current national PA recommendations, which call for PA of at least moderate intensity (64-76% of maximum heart rate), do not consider how people feel (i.e., pleasure or displeasure) while they are exercising, despite the fact that many overweight midlife adults find moderate intensity PA to be aversive. In this study we will compare the effects of an explicit recommendation for self-paced PA versus a traditional intensity-based exercise prescription (based on heart rate range) on PA behavior among previously low-active overweight midlife adults.

PI_NAMEs: WILLIAMS, DAVID M (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Accelerometer;Adherence;Adult;adult obesity;Affective;Age;age related;Alzheimer's Disease;behavioral outcome;Body Weight Changes;Body Weight decreased;Cardiovascular Diseases;Cessation of life;Chronic Disease;Colon Carcinoma;Data;Dementia;displeasure;Energy Metabolism;Exercise;exercise adherence;exercise prescription;Exertion;experience;Feeling;fitness;follow-up;Frequencies;Guidelines;Health Benefit;heart disease risk;Heart Rate;hedonic;improved;Laboratory Study;Malignant Breast Neoplasm;Malignant Neoplasms;Maximum Heart Rate;Measurement;Measures;Mediation;Mediator;Methods;middle age;Modeling;Morbidity - disease rate;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Obesity;Osteoporosis;Overweight;overweight adults;Participant;Patient Self-Report;Persons;Physical activity;Pilot Projects;Play;pleasure;Population;premature;prevent;primary outcome;Procedures;programs;protective effect;Protocols documentation;Public Health;Randomized;Recommendation;recruit;Research;response;Risk;Risk Reduction;Role;sarcopenia;secondary analysis;secondary outcome;Secondary to;Self Determination;Testing;theories;therapy design;treatment effect;trend;vigorous intensity;Walking;Weight;Weight Gain;weight maintenance;Weight maintenance regimen;World Health Organization

PROJECT_TITLE: Comparing a recommendation for self-paced versus moderate intensity physical activity for midlife adults: an RCT


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: In this proposal we will develop a cross-sectional imaging technology termed dynamic µOCT (DµOCT) that identifies distinct cells and tissues using intracellular motility signatures, a proxy of cell activity and state. Research will involve conducting a series of experiments in spheroids, animals, and human tissue to understand the nature of the dynamic signal and determine the diagnostic capacity of this technology for distinguishing disease, cell/tissue activity, and response to therapy. We additionally will develop next generation DµOCT technology that will increase resolution, provide more powerful diagnostic algorithms, and enable the use of DµOCT in living patients.

PI_NAMEs: JONAS, OLIVER ;TEARNEY, GUILLERMO J (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: 3-Dimensional;Algorithms;analysis pipeline;Animal Model;animal tissue;Antineoplastic Agents;ANXA5 gene;Apoptosis;Apoptotic;Architecture;Area;Basic Science;Biological;Biological Sciences;Cancerous;Cell Death;Cell Line;Cell Maturation;Cell Physiology;Cell Proliferation;Cells;Clinical;clinical diagnosis;Clinical Sciences;clinically relevant;contrast imaging;Cytoskeleton;Data;data mining;Data Set;Devices;Diagnostic;diagnostic accuracy;diagnostic algorithm;Dimensions;Disease;disease diagnosis;drug efficacy;Epithelium;experimental study;Fluorescein-5-isothiocyanate;Fluorescence;Fluorescence Microscopy;Frequencies;Grant;Growth;histological slides;Human;human tissue;Image;imaging system;Imaging technology;Immunohistochemistry;Implant;improved;in vivo;Individual;inhibitor;Label;Lateral;Learning;Light;machine learning algorithm;Measures;Melanoma Cell;Metabolic;Metabolism;meter;Methods;microdevice;Microscopic;Microscopy;Modification;Molecular;Morphologic artifacts;Morphology;Motility;Motion;mouse model;Movement;Mus;Nature;Necrosis;new technology;next generation;Optical Coherence Tomography;Optics;Organism;Organoids;Pathology;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Phase;Phase-Contrast Microscopy;Phenotype;Pilot Projects;Process;Proliferating;Propidium Diiodide;Proxy;Research;Resolution;response;Sampling;Scanning;Series;Signal Transduction;Skin;Source;spatiotemporal;Speed;spheroids;Stains;Techniques;Technology;technology validation;temporal measurement;Testing;three dimensional cell culture;Time;Tissue imaging;Tissue Model;Tissues;tool;Training;treatment response;tumor;ultra high resolution;Upper digestive tract structure;validation studies;Visualization

PROJECT_TITLE: Dynamic µOCT for cellular tissue phenotyping

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Prevention

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative  T cell development in the thymus depends on the thymic microenvironment, of which thymic epithelial cells (TECs) are the major component. However, TECs undergo a qualitative and quantitative loss over time, which results in thymic involution and T cell immunodeficiency in older adults, leading to increased susceptibility to infection and cancer, and difficulty in establishing protective immunity via vaccination. The purpose of this project is to develop novel recombinant Foxn1 fusion proteins and to determine the ability of the proteins to rejuvenate the aged TECs, and subsequently to enhance T cell generation in old mice.

PI_NAMEs: LAI, LAIJUN  (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Address;Adult;Age Factors;age related;aged;Aging;Amino Acids;Antibodies;Antigens;Architecture;Atrophic;Autoantigens;Autoimmune Diseases;Autoimmunity;autoreactive T cell;Blood Proteins;care outcomes;Cell Count;Cell Nucleus;Cell Physiology;Cell surface;Cells;Chimeric Proteins;Chronic Disease;Complementary DNA;Cytoplasm;Death Rate;Development;Dose;Drug Kinetics;Elderly;expression vector;Family;fetal;gene cloning;Generations;Genetic;Genetic Transcription;Goals;Health;Human;Immune response;Immune system;Immune Tolerance;Immunity;Immunofluorescence Immunologic;improved;In Vitro;in vivo;Infection;influenza infection;Injections;Insertional Mutagenesis;Intramuscular;Intramuscular Injections;Intravenous;intravenous injection;Lead;life span;Maintenance;Malignant Neoplasms;Mammalian Cell;Mediating;Medicine;member;migration;Modernization;Modification;Mus;novel;novel strategies;old mice;older adult;Organ;Outcome;Output;overexpression;Patients;Penetration;Peptides;Peripheral;peripheral lymphoid organ;Phase;Plasmids;Play;postnatal;Predisposition;prevent;Prevention;Process;Proteins;Reaction;receptor;Recombinants;Regimen;Rejuvenation;restoration;Risk;Rodent;Role;Route;Structure of thymic cortex;subcutaneous;Subcutaneous Injections;System;T-Cell Development;T-Cell Immunodeficiency;T-cell receptor repertoire;T-Lymphocyte;tat Protein;Thymic epithelial cell;thymic regeneration;thymocyte;Thymus Gland;Time;Toxicology;transcription factor;Transgenes;Vaccination;Western Blotting;Winged Helix

PROJECT_TITLE: Treating T cell immunodeficiency among older adults by a recombinant Foxn1 fusion protein

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: MADISON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Parasite infections lead to substantial morbidity and mortality in humans, livestock, and wildlife. Natural selection for host immunity (and parasite infectivity) causes variation in the prevalence and intensity of infection, but little is known about how most parasitic diseases evolve. This research will integrate lab and field experiments to describe how stickleback fishes and cestode parasites evolve to manipulate infection outcomes to their own benefit, how these changes are interdependent (i.e., coevolution), and how the process of coevolution varies over space and time.

PI_NAMEs: WEBER, JESSE NATHANIEL (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Affect;Biological Assay;Candidate Disease Gene;Cells;Cestoda;Coculture Techniques;Data;Dose;Evolution;experimental study;Fishes;forward genetics;Gasterosteidae;Genetic;genetic approach;genetic manipulation;genetic resource;Growth;Helminths;Heritability;Human;Immune;Immunity;In Vitro;Infection;Lead;Livestock;Maps;Measures;Mining;Modernization;Molecular;Morbidity - disease rate;mortality;Natural Selections;Outcome;Parasites;Parasitic Diseases;Parasitic infection;pathogen;Pathway interactions;pharmacologic;Physiology;Population;Prevalence;Process;Protocols documentation;purge;Recording of previous events;Research;resistance mechanism;Series;Specificity;Time;trait;Transgenic Organisms;Transplantation;Variant;Work

PROJECT_TITLE: Mining natural infection variation to find the genetic basis of coevolution between vertebrate hosts and helminth parasites

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Norovirus-infected transplant patients may develop serious sequelae, but the host factors and clinical circumstances that dictate severity of infection are unknown. This proposal explores the role of the gut microbiome in modulating norovirus infections. The results from these studies may yield mechanistic insights on viral pathogenesis of human noroviruses and explore the potential therapeutic role of precision probiotics in the treatment of norovirus infections.

PI_NAMEs: CHONG, PEARLIE PAO EE (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: abstracting;Acute;Adherent Culture;Adult;Anti-viral Agents;Antibiotics;B-Lymphocytes;Bacteroides;Bacteroides fragilis;Binding;Bioinformatics;Blood Group Antigens;CD8-Positive T-Lymphocytes;Cell Separation;Cells;Cessation of life;Childhood;Chronic;Chronic diarrhea;Clinical;Clinical Trials;cohort;Computerized Medical Record;cost;cytokine;Data;Dendritic cell activation;Enteral;enteric virus infection;Enterobacteriaceae;Etiology;Exhibits;experimental study;Family;fecal transplantation;Flow Cytometry;Foundations;Future;Gastroenteritis;Goals;Grant;gut bacteria;gut microbiome;gut microbiota;Health system;Hematopoietic Stem Cell Transplantation;Human;human microbiota;Immune response;Immunocompromised Host;Immunology;Immunosuppression;In Vitro;Incubated;Individual;Infection;Inflammatory;Innate Immune Response;insight;Integration Host Factors;Interferon Type I;Interferon Type II;Interferons;Interleukin-10;Interleukin-4;Interleukin-5;Intestines;Klebsiella;Malnutrition;Mediating;member;Metagenomics;microbiome signature;microbiota profiles;Modeling;Molecular;Mus;Natural History;next generation sequencing;Norovirus;novel;Organ;Pathogenesis;Pathogenicity;Patients;persistent symptom;Physicians;Play;Polysaccharides;Pre-Clinical Model;Probiotics;Production;Proteins;Proteomics;Resolution;response;RNA;Role;Sample Size;Sampling;Scientist;Serum;Severities;Shotgun Sequencing;skills;Solid;stool sample;Surface;T cell response;Taxonomy;Therapeutic;TNF gene;tool;Training;Transforming Growth Factor beta;Transplant Recipients;United States;Viral;Viral Pathogenesis;Virus;Virus Replication;Wasting Syndrome

PROJECT_TITLE: The role of gut microbiota in human norovirus infections in transplant patients

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SALT LAKE CITY

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE The increasing affordability of genome sequencing has created new opportunities to personalize health care. To maximize the clinical impact of genomic information, we must train a workforce of physicians and scientists to interpret and manage genomic data, to work within teams of researchers from different disciplines, and to communicate genomic information effectively and responsibly to patients. Armed with this training, a new generation of scientists will develop and apply precision diagnostics and therapies to provide truly personalized health care.

PI_NAMEs: JORDE, LYNN  (contact)

PROGRAM_OFFICER_NAME: COLLEY, HEATHER

PROJECT_TERMS: Genomic medicine;Training Programs

PROJECT_TITLE: Training Program in Genomic Medicine