NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE A projected doubling of the elderly population by 2050 will dramatically increase the incidence of cognitive impairments associated with Alzheimer’s disease (AD), resulting in tremendous social and economic burdens. Advances in therapeutic or preventive strategies leading to even modest delays in onset and progression could significantly reduce this burden, especially as no real effective treatment at either the clinical or preclinical stage of AD currently exists. The proposed research utilizes a unique 60-year longitudinal cohort to provide new insights into factors from early childhood to later adulthood that impact neurocognitive mechanisms of reserve which, in turn, may serve to both delay the onset of AD pathology and moderate the impact of AD pathology and other age-related brain changes on cognitive decline.

PI_NAMEs: BUKA, STEPHEN L;HEINDEL, WILLIAM C (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: 7 year old;Address;Adolescence;Adult;Affect;Age;age related;Age related pathologies;Age-associated memory impairment;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid beta-42;Amyloid beta-Protein;Anatomy;Apolipoprotein E;Birth;Brain;Brain Pathology;Child;Childhood;childhood adversity;Clinical;Cognition;Cognitive;cognitive ability;Cognitive aging;cognitive control;cognitive function;cognitive neuroscience;cognitive testing;cohort;Cohort Studies;Data Collection;Development;early childhood;Economic Burden;Economics;Education;effective therapy;Elderly;Equilibrium;ethnic diversity;Etiology;Failure;Family;Functional Magnetic Resonance Imaging;Genotype;Health Status;Healthcare Systems;Impaired cognition;Incidence;Income;indexing;Individual;Individual Differences;insight;Investigation;late life;Life;Life Cycle Stages;Life Experience;life span;lifestyle factors;Link;Longitudinal cohort;Measures;member;middle age;neural network;Neurocognitive;neuroimaging;neuroprotection;Neuropsychology;novel;novel strategies;Occupational;Onset of illness;Outcome;Participant;Pathway interactions;Pattern;Perinatal;Phase;Physical activity;Plasma;Population;pre-clinical;Pregnancy;prenatal;prevent;Prevention strategy;programs;prospective;Race;Research;resilience;Risk;Saliva;Sampling Studies;social;Social Behavior;System;Therapeutic;Time

PROJECT_TITLE: Mechanisms of Risk and Resilience to Age-Related Cognitive Decline: A 60-Year Prospective Prenatal Cohort


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: CHARLOTTESVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE The Cancer Research Training Program (CRTP) described herein is designed to prepare the next generation of young investigators for successful careers in cancer research. By providing trainees with the practical skills to perform high-quality research, the foundational knowledge to cultivate a process of life-long learning, and the skills to be part of a dynamic and interactive research team, the CRTP will help to create a new generation of cancer researchers who are uniquely prepared to make inroads into understanding and treating cancer.

PI_NAMEs: DUDLEY, ANDREW CARL (contact);RUTKOWSKI, MELANIE R

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TITLE: Cancer Research Training Program: From Molecular Mechanisms to Therapeutic Strategies

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Regenerative Medicine

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The OHSU SOD is uniquely positioned to offer this comprehensive research mentoring and training PORT for the next generation of oral health scientists since we are the only dental school in the state of Oregon, supported by robust OHSU and state-wide research and research training resources. We are committed to address current and future shortages in the oral health research workforce by preparing a diverse and inclusive cadre of individuals for careers as independent scientists. Our objective is consistent with NIDCR’s mission to advance national research needs in the dental, oral and craniofacial health and science.

PI_NAMEs: WU, HUI  (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Acceleration;Address;Award;Basic Science;Biocompatible Materials;career;Clinical Research;Creativeness;Dentists;design;Doctor of Philosophy;Education;Educational workshop;Effectiveness;Environment;Event;experience;Fellowship;Funding;graduate student;Grant;Health;innovation;Institution;interdisciplinary approach;interest;Knowledge;Leadership;Master of Science;matriculation;Mentors;Mentorship;microbial;National Institute of Dental and Craniofacial Research;Oral health;Oregon;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Productivity;programs;Public Speaking;Qualifying;Recording of previous events;Regenerative Medicine;Research;Research Personnel;Research Training;School Dentistry;Schools;Science;Scientist;Series;Structure;Students;Tissue Engineering;Training;training opportunity;Training Programs;Translational Research;undergraduate research experience;undergraduate student;United States National Institutes of Health;Universities;Visit;workforce needs;Writing

PROJECT_TITLE: PORT (Portland Oral health Research Training)


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The Adolescent Health Promotion Research Training Program provides training in sexual and reproductive health research to post-doctoral physicians training in Adolescent Medicine. This program is designed to address national health and workforce disparities in adolescent health and responds to the Healthy People 2030 objectives. Physician graduates will ultimately contribute to the scientific development of innovative and effective prevention strategies for pregnancy and sexually transmitted infections, including the human immunodeficiency virus, among youth.

PI_NAMEs: TRENT, MARIA E. (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: adolescent health;Training Programs

PROJECT_TITLE: Adolescent Health Training Program


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biotechnology;Clinical Research;Lung;Orphan Drug;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative Acute respiratory distress syndrome (ARDS) is a common and life-threatening condition that is most frequently caused by sepsis, has a 30-50% death rate, and has no disease-specific therapies. The goal of my research program is to develop a discovery and mechanistic pipeline to identify clinically relevant mediators of ARDS, and rapidly translate the most promising findings into pre-clinical models. Using our novel discovery methods, model systems and translational research approach, we will transform our understanding of ARDS pathogenesis and lay the groundwork for future clinical trials.

PI_NAMEs: BASTARACHE, JULIE ANNE (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Acute respiratory failure;Affect;Alveolar;American;Biological Models;Blood capillaries;Catalogs;Cells;Clinical Trials;clinically relevant;cost;Coupled;Data;Death Rate;design;Development;Disease;flexibility;Functional disorder;Future;Gene Expression Profile;Goals;Health;Human;human model;Impairment;In Vitro;in vivo;injured;innovation;insight;Institution;Laboratories;Life;Lung;lung injury;Maps;mass spectrometric imaging;Mediator;Methods;Mission;Modeling;Molecular;mouse model;Mus;National Heart, Lung, and Blood Institute;new therapeutic target;novel;novel strategies;novel therapeutics;Pathogenesis;Pathologic;Pathology;Patients;Permeability;Phenotype;pre-clinical;Pre-Clinical Model;preclinical study;programs;protein expression;Proteins;Research;Resources;Sepsis;single-cell RNA sequencing;Statistical Methods;Structure of parenchyma of lung;systems research;targeted treatment;Testing;therapeutic target;Tissues;Transgenic Model;Transgenic Organisms;Translating;Translational Research;Translations

PROJECT_TITLE: Applying Innovative Lung Mapping Strategies to Understand Alveolar Capillary Barrier Permeability in ARDS


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Liver Disease;Nutrition;Obesity

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Systemic chronic inflammation is a common comorbidity of type 2 diabetes and inflammatory bowel disease, affecting a patient’s immune, nervous, endocrine, and reproductive systems. The contribution of postprandial inflammation to the systemic chronic inflammation in those contexts remains unclear. This study seeks to identify this missing link and understand how intestinal track displaced hyaluronan promotes liver Kupffer cell Marco expression to promote hepatic and systemic inflammation.

PI_NAMEs: ZHU, YI  (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Acute;Adipose tissue;Affect;Animal Model;bariatric surgery;Binding;Blood;CD44 Antigens;CD44 gene;Cells;Cessation of life;Chronic;Chronic Disease;Circulation;combat;comorbidity;cytokine;Data;Development;Diet;diet-induced obesity;Dietary Component;Digestion;Disease;Dose;Eating;Endocrine system;Endotoxemia;gastrointestinal;Genetically Engineered Mouse;gut inflammation;gut microbiota;HAS2 gene;Hepatic;Human;human subject;Hyaluronan;Hyperglycemia;Hyperlipidemia;immune activation;Immune system;Impairment;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Ingestion;Intestines;knock-down;Knock-out;Knockout Mice;Knowledge;Kupffer Cells;Leukocytes;Link;Liver;liver inflammation;Macrophage;Modeling;Modernization;Molecular;Molecular Weight;monocyte;mouse model;Movement;Mus;Nervous System;Non-Insulin-Dependent Diabetes Mellitus;novel;Nucleotides;Obesity;Organ;overexpression;pathogen;Pathology;Patients;Pattern;Pattern recognition receptor;Physiological;Plasma;Process;Production;Publications;receptor;Reproductive system;Research;response;RNA Interference;Role;Saturated Fatty Acids;Serum;Sodium Dextran Sulfate;Source;Sperm Adhesion Molecule 1;SR-A proteins;Stimulus;Structure;Surveys;systemic inflammatory response;temporal measurement;Testing;Tissues

PROJECT_TITLE: Postprandial activation of hyaluronan-MARCO axis contributes to systemic chronic inflammation

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Cancer;Chronic Pain;Clinical Research;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Prevention;Rehabilitation

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting toxicity of cancer treatment that often presents with debilitating pain, yet no effective preventive or treatment strategies exist. To improve the quality of life of cancer survivors, our project will examine spinal cord stimulation (SCS) as a promising non-pharmacologic strategy for CIPN pain and enhancement of chemo-efficacy.

PI_NAMEs: SIVANESAN, EELLAN  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acceleration;Aftercare;American Society of Clinical Oncology;Amyloid beta-Protein;Anesthesiology;Attenuated;attenuation;Biology;Blood Vessels;C Fiber;Calcium;Cancer Biology;cancer cell;cancer pain;Cancer Survivor;cancer therapy;career;Cell Proliferation;chemotherapy;Chemotherapy-induced peripheral neuropathy;chronic pain patient;chronic painful condition;Clinical;Clinical Trials;clinically relevant;control theory;Coupled;Data;debilitating pain;Development;dorsal column;Dose;Dose Limiting;Electric Stimulation;Electrophysiology (science);Environment;Evaluation;experimental study;Exposure to;Foundations;Funding;Future;Glioma;Goals;Human;Image;Immune;Immunology;improved;In Vitro;Infiltration;Inflammation;Inflammation Mediators;Injury;insight;Instruction;Investigation;Knowledge;Macrophage;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Mediator;medical schools;meetings;Mentors;Mentorship;minimally invasive;Modality;Modeling;Motor;Neuroimmune;neuroimmunology;Neuroimmunomodulation;neuronal excitability;Neurons;neuroregulation;Neurosciences;Neurostimulation procedures of spinal cord tissue;Nociception;Non-Small-Cell Lung Carcinoma;novel;Paclitaxel;Pain;pain behavior;pain inhibition;Pain management;painful neuropathy;Patient-Focused Outcomes;Patients;Perfusion;Peripheral;Peripheral Nervous System;Pharmaceutical Preparations;Prevalence;prevent;Prevention;Prevention strategy;Preventive treatment;Proliferating;Quality of life;quality of life for cancer survivors;Rattus;recruit;Refractory;Research;Research Personnel;Rodent;Safety;Scientist;side effect;Skin Cancer;somatosensory;Spinal;Spinal Ganglia;Sprague-Dawley Rats;Structure;Supervision;Technology;Testing;Therapeutic Intervention;Time;tool;Toxic effect;Training;Translating;translational study;Treatment Efficacy;treatment optimization;Treatment outcome;treatment strategy;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor-associated macrophages;Universities;Work

PROJECT_TITLE: Spinal cord stimulation for the attenuation of chemotherapy-induced peripheral neuropathy and enhanced chemotherapeutic efficacy

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: TAMPA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative The proposed research is relevant to public health because it is designed to produce preclinical groundwork for new strategies to reduce elevations in microvascular permeability that worsen outcomes of traumatic injury. The project is relevant to the part of the NIH mission that pertains to developing fundamental knowledge that will help prevent disability and early loss of life.

PI_NAMEs: BRESLIN, JEROME W (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Address;Alcoholic Intoxication;Applications Grants;Biological Markers;Blood;Blood Vessels;Caring;Cell model;Cells;clinically relevant;design;Development;Disability prevention;Endothelial Cells;Endothelium;Experimental Models;Extravasation;Functional disorder;Gene Expression;Goals;Hemorrhagic Shock;Human;improved;improved outcome;Injury;Knowledge;knowledge base;leukocyte activation;Life;lipidomics;Liquid substance;metabolomics;Methods;Microvascular Permeability;Mission;Modeling;Molecular;Monitor;Multiple Organ Failure;novel;novel therapeutics;Organ;Outcome;Patients;Permeability;personalized therapeutic;Physicians;Plasma;pre-clinical;prevent;Proteomics;Public Health;Research;Resolution;Resuscitation;Rodent Model;Sepsis;Shock;Signal Transduction;systemic inflammatory response;Therapeutic;Therapeutic Intervention;Time;tissue trauma;Tissues;transcriptome sequencing;translational impact;Trauma;Trauma patient;Traumatic injury;United States National Institutes of Health;Vascular Endothelium;venule

PROJECT_TITLE: Microvascular Leakage in Hemorrhagic Shock and Trauma

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Immunotherapy;Liver Cancer;Liver Disease;Nutrition;Obesity;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Many cancers, including colon cancer, are more aggressive in obese patients, but the explanation is unknown. We recently discovered that colon cancer grows faster in diet-induced obese mice and our preliminary findings suggest that such rapid growth is caused by overexpression of a molecule called GPR65 on the macrophages in the tumors of these mice, resulting in impaired anti-tumor immunity. In this project, we will identify the mechanism by which GPR65 becomes activated and promotes the growth of colon and other cancers.

PI_NAMEs: ENGLEMAN, EDGAR G.  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Acceleration;Acidity;Acids;Adult;Affect;anti-PD-1;Automobile Driving;Biological Assay;Blocking Antibodies;Blood donor;Cancer Etiology;cancer therapy;Cell Physiology;cell type;Cells;colon cancer patients;Colon Carcinoma;colon growth;Colorectal Cancer;CTLA4 gene;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;cytokine;Data;Development;Diet;diet-induced obesity;dietary;Disease;Exhibits;fatty acid oxidation;Flow Cytometry;Frequencies;Genus Hippocampus;Growth;High Fat Diet;Human;human data;Immune;immune checkpoint blockade;Immune response;Impairment;Inflammatory Response;innate immune mechanisms;KRASG12D;Lipids;Macrophage;Malignant Neoplasms;MC38;Mediator;Melanoma;Modeling;mortality;mouse model;Mus;neoplasm immunotherapy;neoplastic cell;Non obese;novel;Obese Mice;obese patients;Obesity;obesogenic;Oleic Acids;Outcome;overexpression;Overweight;Patients;Play;Population;Predisposition;Primary carcinoma of the liver cells;Production;Prognosis;programmed cell death ligand 1;rapid growth;receptor;response;Risk;Role;Sampling;Signal Transduction;Societies;Solid Neoplasm;subcutaneous;Testing;Therapeutic Effect;therapy outcome;TNF gene;Triglycerides;tumor;tumor growth;Tumor Immunity;tumor metabolism;tumor microenvironment;Tumor Promotion;Tumor-associated macrophages;United States

PROJECT_TITLE: Innate Immune Mechanisms Contributing to Cancer Growth in Obesity

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: RICHMOND

ORG_DEPT: ADMINISTRATION

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: PROJECT NARRATIVE FDA’s recent efforts towards banning menthol cigarettes must be paired with evidence-based tobacco regulatory policies that maximize the likelihood that menthol smokers respond by quitting tobacco use altogether or switching to modified risk tobacco products (MRTP) instead of non-menthol cigarettes. This project examines the influence of flavor availability on switching to an MRTP known as IQOS, part of the Heated Tobacco Product (HTP) class, among menthol smokers using clinical lab and naturalistic evaluations of abuse liability. Results will help federal regulators predict the public health impact on menthol cigarette smokers of policies restricting access to menthol-flavored HTPs.

PI_NAMEs: WHITE, AUGUSTUS MICHAEL (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: abuse liability;access restrictions;addiction;Address;Adult;arm;Authorization documentation;Behavior;behavior measurement;Behavioral;behavioral pharmacology;Blood;Cigarette;cigarette craving;cigarette smoke;Cigarette Smoker;cigarette smoking;Clinical;clinical translation;Clinical Trials;Collection;combustible cigarette;Congresses;Country;craving;Data;Data Analyses;Development;Ecological momentary assessment;Emerging Tobacco Products;Environment;Evaluation;evidence base;Funding;Future;Goals;Health;heated tobacco products;interest;Intervention;Learning;Legal;Measures;Medicine;Menthol;Mentorship;Methods;Modified Risk Tobacco Product;Morbidity - disease rate;mortality;Nicotine;novel;Outcome;Participant;Pattern;Pharmaceutical Preparations;Physicians;Physiological;Plasma;Policies;Policy Maker;Public Health;public policy on tobacco;Randomized;Reporting;Research;response;Sampling;Scientist;Signal Transduction;skills;Smoker;Smoking;smoking cessation;success;Targeted Research;Tobacco;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco use;Training;Translational Research;United States Food and Drug Administration;United States National Institutes of Health;Validity of Results;Visit;willingness;Work

PROJECT_TITLE: The Abuse Liability of a Novel Heated Tobacco Product (IQOS) and Its Feasibility as a Menthol Cigarette Substitute.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(21)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Genetics;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Innovative implementation strategies for HIV prevention are needed in the Southern US to decrease HIV transmission. Engaging high risk contacts of sexual and gender minority people with newly acquired HIV through social network methods may have higher yield in reaching those who would benefit from immediate linkage to HIV treatment or prevention services than standard partner services. The proposed research aims to evaluate HIV transmission networks in North and South Carolina, and to develop and implement a partner services intervention to use social network strategy to increase testing and linkage to HIV care or prevention.

PI_NAMEs: DENNIS, ANN  (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Acute;Address;Advocate;AIDS prevention;Anti-Retroviral Agents;Area;Behavior;Behavioral;Biological;black men who have sex with men;Caring;case finding;Cluster Analysis;Collaborations;community engagement;community involvement;Contact Tracing;County;Data;design;Detection;Development;Diagnosis;Disparity;distrust;Drug usage;effectiveness evaluation;effectiveness outcome;Ensure;Epidemic;epidemic response;Epidemiology;Evaluation;evidence base;experience;Friends;gender minority group;Genetic;Goals;high risk;high risk population;HIV;HIV diagnosis;HIV Infections;HIV Seropositivity;Human immunodeficiency virus test;hybrid type 1 design;implementation outcomes;implementation strategy;improved;Incidence;indexing;Individual;Infection;innovation;Intervention;Investigation;Knowledge;Link;Logistics;member;Methods;metropolitan;Molecular Epidemiology;multidisciplinary;Names;Newly Diagnosed;next generation;North Carolina;Notification;Outcome;Pathway Analysis;peer;Persons;Pharmaceutical Preparations;post intervention;pre-exposure prophylaxis;Prevention;prevention service;Public Health;Quasi-experiment;recruit;Reporting;Research;Resources;response;Risk;Rural;rural area;rural counties;Sequence Analysis;service engagement;service intervention;service utilization;Services;sex;Sexual and Gender Minorities;Sexual Partners;social;social contact;Social Network;social stigma;Social support;Source;South Carolina;standard of care;success;Testing;tool;transgender women;transmission process;treatment services;United States;uptake;urban area;Viral;Virus

PROJECT_TITLE: Rapid Response to Incident HIV Infection through Social Network Strategies and Molecular Epidemiology to Inform Partner Services


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Cardiovascular disease is the leading cause of death in diabetic patients. In previous grant cycles, we identified a novel pathway linking diabetes to atherosclerosis; in our preliminary data, we identified a compound that can inhibit this pathway. We expect that our work will yield a safe, effective drug to prevent cardiovascular disease in diabetic patients.

PI_NAMEs: BIDDINGER, SUDHA B (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Amines;Atherosclerosis;Bromides;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cause of Death;Cells;Cholesterol;Choline;Clinic;Clinical Research;cytokine;Data;Development;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;drug repurposing;Dyslipidemias;endoplasmic reticulum stress;Enzymes;FMO3;FOXO1A gene;Gene Expression Profiling;Glucagon;Glucose;Goals;Grant;gut microbes;gut microbiome;gut microbiota;Half-Life;Hepatic;Human;Hyperglycemia;Individual;Inflammation;inflammatory marker;inhibitor;Insulin;Insulin Resistance;knock-down;Libraries;Link;Lipids;Liver;Low Density Lipoprotein Receptor;Measures;Mediating;Mediator;Metabolic;Metabolic dysfunction;microbial;Modeling;Molecular;mouse model;Mus;new therapeutic target;novel;Oxides;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Plasma;Post-Translational Protein Processing;prevent;Production;Publishing;receptor;response;Role;Signal Transduction;stress kinase;targeted treatment;Testing;Therapeutic;therapeutic evaluation;therapy development;Time;transcription factor;transcriptomics;Ubiquitination;Work

PROJECT_TITLE: Pathogenesis of Dyslipidemia and Atherosclerosis in the Diabetic State


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Primary Health Care;Substance Misuse

ORG_CITY: ATHENS

ORG_NAME: OHIO UNIVERSITY ATHENS

ORG_STATE: OH

PHR: Project Narrative: Safety-net hospitals are ideal sites to stage evidence-based OUD services such as transitional opioid programs (TOPs) that link hospitalized patients to community-based outpatient settings in underserved communities. However, these institutions are less likely to offer OUD services, due in part to barriers that are not well understood. In this study, we will assess the current opioid programs offered by safety net hospitals, explore barriers and facilitators to adopting and implementing TOPs by interviewing hospital decision makers and community partners at five safety net hospitals, and convene an expert panel to identify and tailor high-yield implementation strategies to increase the availability of transitional opioid programs and other evidence-based opioid services in underserved communities.

PI_NAMEs: CHANG, JI E;FRANZ, BERKELEY  (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Acute;addiction;Address;Adopted;Adoption;beneficiary;Budgets;Buprenorphine;Caring;Catalogs;Centers for Disease Control and Prevention (U.S.);Characteristics;Chronic;Collaborations;Communicable Diseases;Communities;community barrier;community based service;Community Hospitals;community partners;community partnership;Data;Decision Making;disease transmission;Disparity;Economic Burden;Economics;effectiveness testing;Endocarditis;Ensure;evidence base;Evidence based program;Extramural Activities;Face;follow-up;Funding;Future;Goals;Harm Reduction;Health;Health Services;Health Services Accessibility;Healthcare Systems;Hepatitis C;HIV Infections;Hospitalization;Hospitals;implementation barriers;implementation science;implementation strategy;Improve Access;improved;Infectious Skin Diseases;Institution;Interdisciplinary Health Team;Intervention;Interview;Investments;Knowledge;Link;Logistic Regressions;longitudinal database;Medicaid;medication for opioid use disorder;Methods;Morbidity - disease rate;mortality;Opioid;opioid misuse;opioid overdose;opioid use;opioid use disorder;Outcome;Outpatients;Overdose;patient engagement;Patients;Pattern;Persons;Play;programs;Provider;Public Health;Publications;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Resources;Role;rural setting;safety net;Sampling;Schedule;secondary infection;Service provision;Services;Site;social;social stigma;Soft Tissue Infections;Stress;Testing;Time;trend;Typology;Underinsured;underserved community;Uninsured;United States;uptake;urban setting

PROJECT_TITLE: Developing Implementation Strategies to Improve Access to Transitional Opioid Programs in Safety Net Hospitals

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PHR: NARRATIVE Human samples contain immense riches of data, but are extremely precious as experiments consume them. To solve this problem, we propose developing a new method that indefinitely preserves such material across experiments. This means ideally limitless experiments can be performed to improve accuracy, or different ones can be performed to look at different types of information afforded by the sample.

PI_NAMEs: LAU, BILLY TSZ CHEONG (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Algorithms;assay development;Bioinformatics;Biological Assay;Biological Models;Biology;Cells;Cellular biology;Characteristics;cohort;Complementary DNA;Complex;computer framework;Consumption;Data;data integration;Data Set;Development;DNA;Dropout;Engineering;experimental study;Genome;Genomics;Goals;Human;Human Biology;human disease;Hybrids;improved;innovation;Libraries;Lymphocyte;magnetic beads;Methods;Molecular;multiple omics;Peripheral;Phase;Polymerase;Preparation;preservation;Primer Extension;programs;Research;Sampling;scale up;Sepharose;Signal Transduction;single cell sequencing;Solid;Source;Techniques;Technology;transcriptome sequencing;Vision

PROJECT_TITLE: Omics information maximization in single-cell sequencing with hybrid molecular and computational approaches


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: ATLANTA

ORG_DEPT: GENETICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Renal cysts are fluid-filled sacs that interfere with normal kidney function. Dysfunction of primary cilia or of cilia-associated proteins can lead to cystic kidneys so it is critical to understand the role of such proteins in renal cyst formation. Here we use a novel mouse model as an entry point to genetically isolate ciliary signaling in the context of known molecular players of cyst formation, and determine whether and when it can reverse renal cysts.

PI_NAMEs: CASPARY, TAMARA J. (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Ablation;ARL3 gene;Autosomal Dominant Polycystic Kidney;Biochemical;Cells;Cilia;Clinical;Cyst;Cyst Fluid;Cystic kidney;Cystic Kidney Diseases;Data;Dissection;Economic Burden;End stage renal failure;Engineering;Exclusion;experimental study;forging;Frustration;Functional disorder;Future;Gene Deletion;Genes;Genetic;Genetic Models;Genets;Goals;Growth;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;Health;insight;Kidney;kidney cell;Knowledge;Liver diseases;Mediator;Molecular;molecular targeted therapies;Morphology;mouse model;Mus;mutant;Mutation;novel;optimal treatments;Pathway interactions;Phenotype;Play;Polycystic Kidney Diseases;Proprotein Convertase 1;Proprotein Convertase 2;Proteins;PubMed;Renal function;Research;Role;SHH gene;Signal Transduction;smoothened signaling pathway;Testing;Therapeutic Intervention;therapeutic target;tool;trafficking;United States;Variant;Work

PROJECT_TITLE: Genetic dissection of ciliary ARL13B in kidney cystogenesis

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative Sepsis remains a major cause of morbidity and mortality; however development of effective therapies for sepsis treatment represents a major challenge. Using preclinical models of lung inflammation caused by live methicillin-resistant Staphylococcus aureus (USA300 clinical strain 923) and inactivated Staphylococcus aureus particles to recapitulate sterile septic conditions after antibiotic treatment, this study will investigate local regulation of lung microvascular barrier function via cell junction-associated molecular mechanisms promoting reduction of inflammatory signaling and recovery of endothelial barrier. This study may lead to discovery of a new group of pharmacological molecules for the treatment of sepsis and other diseases associated with increased vascular leakage and inflammation.

PI_NAMEs: BIRUKOVA, ANNA  (contact)

PROJECT_TERMS: Abdomen;Acceleration;Acute;Adhesions;Adhesives;Advanced Development;Agonist;Antibiotic Therapy;Arterial Fatty Streak;attenuation;Automobile Driving;Bacterial Model;Blood Vessels;Cell Adhesion;Cells;Clinical;Coagulation Process;cytokine;cytokine release syndrome;Data;Death Rate;Development;Disease;Edema;effective therapy;Endothelial Cells;Endothelium;experimental study;Extravasation;Feedback;Functional disorder;Future;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;improved;in vivo;Incidence;Infection;Inflammation;Inflammatory;Injury;Intercellular Junctions;Intervention;Leukocytes;Lung;lung injury;lung microvascular endothelial cells;mechanical force;Mediating;methicillin resistant Staphylococcus aureus;Microtubules;migration;Molecular;Monomeric GTP-Binding Proteins;Morbidity - disease rate;mortality;Multiple Organ Failure;Myocardial Ischemia;novel;Organ;particle;pathogen;Pathologic;Pathologic Processes;Pathway interactions;Peripheral;Permeability;pharmacologic;polypeptide;Pre-Clinical Model;Process;Proteins;pulmonary function;Pulmonary Inflammation;Recovery;recruit;Regulation;Reperfusion Therapy;research study;response;restoration;rho;Role;Sepsis;septic;Signal Transduction;Source;Staphylococcus aureus;Sterility;Stimulus;Structure;Tertiary Protein Structure;Testing;Therapeutic;Thrombin;TNF gene;Translational Research;Urinary tract;Vascular Endothelial Cell;Vascular Endothelium;vascular inflammation;Vascular Permeabilities

PROJECT_TITLE: Control of septic inflammation and lung microvascular endothelial barrier by cell junction signaling nexus

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: SEATTLE

ORG_NAME: PACIFIC NORTHWEST RESEARCH INSTITUTE

ORG_STATE: WA

PHR: PROJECT NARRATIVE Almost half of the human genome sequence has been created by self-replicating, genome-bound transposable elements like L1, and the replication of these elements can cause numerous diseases including cancer, autoimmunity, and infertility. Despite their persistence and prevalence, the functional consequences of the evolution of L1s is incompletely understood. We propose to study how L1s evade the factors used by the human genome to block their replication and how evasive L1s might impact human health. (3 sentences)

PI_NAMEs: MCLAUGHLIN, RICHARD NOEL (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Autoimmune Diseases;Autoimmunity;Automobile Driving;Basic Science;Binding;Biology;comparative genomics;Creativeness;Dedications;Defense Mechanisms;Directed Molecular Evolution;Disease;DNA;DNA Transposable Elements;Elements;Evolution;experience;experimental study;fascinate;Genetic;Genetic Diseases;Genome;genome analysis;Genomic Instability;Health;Human;Human Biology;Human Genome;In Vitro;Infertility;Innate Immune System;interest;Long Interspersed Elements;Malignant Neoplasms;Mentorship;Mutation;outreach;Pattern;pressure;Prevalence;prospective;Proteins;Recording of previous events;Repression;Research;Retroelements;Retrotransposon;RNA;Science;Scientist;Selfish DNA;Source;Speed;System;Variant

PROJECT_TITLE: Leveraging natural and directed evolution to dissect the functional consequences of sequence variation in human L1 retrotransposons

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Tolvaptan, which has limited efficacy and significant toxicity, is the only approved treatment that slows the decline of renal function in patients with ADPKD in the US. Among the most promising drug candidates are protein and lipid kinases. We applied a new strategy to identify novel kinases up-regulated in PKD kidneys and will determine whether inhibiting or activating any of these kinases slows cyst growth and progression of kidney disease with the goal to identify new kinases that are potential targets to slow cyst growth in patients.

PI_NAMEs: SKOLNIK, EDWARD Y (contact)

PROJECT_TERMS: Affect;Affinity;Animal Model;Autosomal Dominant Polycystic Kidney;Binding;Biological Assay;Clinical Trials;Collaborations;Combined Modality Therapy;Couples;Cyclic GMP;Cyst;Data;discoidin domain receptor 1;Doxycycline;drug candidate;Drug Targeting;End stage renal failure;Epithelial cyst;Extracellular Matrix;Fibrosis;Focal Adhesion Kinase 1;Funding;Genes;Genetic;genetic approach;Goals;Grant;Growth;Human;human disease;in vivo;inhibitor;insight;interest;interstitial;Kidney;Kidney Diseases;kinase inhibitor;Lipids;Mass Spectrum Analysis;Mediating;Medicine;Messenger RNA;mouse model;Mus;Mutation;new therapeutic target;novel;novel strategies;Pathogenesis;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;Play;polycystic kidney disease 1 protein;posttranscriptional;preservation;Proliferating;Proprotein Convertase 1;Proprotein Convertase 2;Proteins;PTK2 gene;Publishing;Renal function;Role;Signal Pathway;Signal Transduction;tandem mass spectrometry;Techniques;Technology;Testing;Therapeutic;therapeutic target;Time;tolvaptan;Toxic effect;Translating;Universities

PROJECT_TITLE: Identification of new therapeutic targets for ADPKD


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Complementary and Integrative Health;Dietary Supplements;Neurosciences;Stroke

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative  The proposal is focused on determining therapeutic mechanisms of a novel therapeutic strategy, post- ischemic acute injection of the DHA metabolite, NPD1. This strategy is based on our novel findings that out of several DHA metabolites, Resolvin D1, NPD1 and Resolvin D2, only NPD1 afforded robust protection against neonatal hypoxic-ischemic brain injury and this was coupled with beneficial effect on mitochondrial function. Potential implication of this research is very broad, because post-ischemic mitochondrial dysfunction is one of the major mechanisms of tissue damage driven by reperfusion injury.

PI_NAMEs: CHANG, CHUCHUN LIZ (contact);TEN, VADIM S

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Acute;Address;Affect;Anabolism;Animals;Apoptotic;Attenuated;attenuation;BAX gene;Bioenergetics;Blood;Brain;Brain Hypoxia-Ischemia;Brain Ischemia;Buffers;Cardiovascular Diseases;Cell Death;cell injury;Cell Membrane Permeability;Cerebrum;Cessation of life;Clinical;clinical application;Complex;Coupled;Docosahexaenoic Acids;Eicosapentaenoic Acid;Electric Conductivity;Emulsions;Event;Failure;Fatty Acids;Functional disorder;Gender;Human;hypoxic ischemic injury;Hypoxic-Ischemic Brain Injury;improved;In Vitro;in vivo;Injections;Inner mitochondrial membrane;innovation;Ischemia;Ischemic Brain Injury;Ischemic Stroke;Liver;Measures;Mediating;Mediator;Membrane;Metabolism;Microscopy;Mitochondria;mitochondrial dysfunction;Mitochondrial Matrix;mitochondrial membrane;Mus;natural hypothermia;neonatal hypoxic-ischemic brain injury;neonatal stroke;neurobehavioral;Neurologic;Neurons;neuroprotectin D1;neuroprotection;novel;novel therapeutic intervention;Omega-3 Fatty Acids;Organ;Outer Mitochondrial Membrane;Oxidative Phosphorylation;patch clamp;Pathologic;Pathway interactions;Permeability;pharmacologic;Plasma;preservation;prevent;Property;Protons;Recovery;Reperfusion Injury;Reperfusion Therapy;Reporting;Research;Respiration;Rodent Model;Role;Severities;Spleen;Stroke;Testing;Therapeutic;therapeutic target;Time;Tissues;translational impact;translational study;Triglycerides

PROJECT_TITLE: Omega 3 Fatty Acids, Acute Neuroprotection Via Mitochondria


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

PHR: In order to improve diagnostic quality, we need a systematic approach to measure it in large-scale data across clinical providers. In this project, we will develop such an approach and apply it to the specific setting of emergency department radiology, using data covering millions of visits and thousands of radiologists. Measures of diagnostic quality across a large number of clinicians in a wide range of locations will enable us to understand not only the determinants of diagnostic quality at the provider- and system-level but also its relationship with patient health outcomes.

PI_NAMEs: CHAN, DAVID CHIMIN (contact)

PROGRAM_OFFICER_NAME: HAUGSTETTER, MONIKA

PROJECT_TITLE: Measuring and Understanding Diagnostic Quality from Large-Scale Data

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Understanding how adult blood stem cells maintain themselves is essential for developing future cellular therapies and treating blood diseases including anemias, myelodysplastic disorders and hematopoietic malignancies. Previously, we found that the MUSASHI2 gene is essential for blood stem control and elevated abundance in patients with myelodysplastic syndromes results in a poor outcome. This proposal studies the mechanisms of the MUSASHI2 regulatory network for the development of novel future therapeutic strategies.

PI_NAMEs: KHARAS, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Address;Adult;Anemia;Bar Codes;Binding;Biology;Blood;Blood Cells;Bone Marrow;bone marrow failure syndrome;Cell division;Cell Lineage;Cell Therapy;Cells;clinical prognosis;Communication;conditional knockout;cytopenia;Data;Daughter;Defect;Development;Disease;Disease Progression;Dysmyelopoietic Syndromes;Engraftment;Failure;Future;Gene Expression;Genes;Genetic;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic hierarchy;Hematopoietic Neoplasms;hematopoietic stem cell differentiation;hematopoietic stem cell fate;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Hematopoietic System;Immune system;improved outcome;in vivo;insight;Journals;Laboratories;leukemia;leukemic stem cell;leukemogenesis;Lymphoid;Maintenance;Malignant Neoplasms;Mammalian Cell;Maps;Mediating;Medicine;Messenger RNA;Methods;Molecular;Morphology;mouse model;Myelogenous;Nature;new technology;Normal Cell;novel;novel therapeutic intervention;Outcome;overexpression;Pathway interactions;Patients;Phenotype;Process;progenitor;programs;Proteomics;Regulation;RNA-Binding Proteins;Role;self-renewal;Signal Transduction;single-cell RNA sequencing;small hairpin RNA;stem;Stem Cell Assay;stem cell differentiation;stem cell engraftment;stem cell expansion;Technology;Therapeutic;Therapeutic Intervention;Transforming Growth Factor beta;Transplantation;Work

PROJECT_TITLE: Uncovering the role for MSI2 network in hematopoietic stem cells

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


ORG_DEPT: PHARMACOLOGY

PHR: NARRATIVE Lung cancer accounts for more than 1.5 million deaths worldwide each year. This proposed Emory University P01 program intends to generate new therapeutic strategies for treating lung cancer patients by improving understanding of the dysregulated growth regulatory and immunotherapy resistance mechanisms in lung cancer patients with lost LKB1. Overseen by an Executive Committee, Internal and External Advisory Boards, the program will encompass three interconnected research projects supported by three core resources and an interdisciplinary team that will integrate novel insights from LKB1 biology and its role in resistance to immunotherapy in order to discover innovative clinical strategies for lung cancer patients based on LKB1 status.

PI_NAMEs: FU, HAIAN  (contact);RAMALINGAM, SURESH S

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Address;anti-cancer;Bioinformatics;Biology;Biometry;Biostatistics Core;BRAF gene;cancer cell;Cancer Etiology;cancer immunotherapy;Cancer Patient;central database;Cessation of life;checkpoint therapy;Cisplatin;Clinic;Clinical;clinical application;clinical translation;Clinical Trials;Colon Carcinoma;Combination immunotherapy;Coupled;Data;Data Analyses;data sharing;Development;Disease;driver mutation;effective therapy;Epidermal Growth Factor Receptor;Event;Experimental Designs;Fostering;Frequencies;Genes;Glutamate Dehydrogenase;Goals;Grant;Growth;Hematologic Neoplasms;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;Immunology;Immunosuppression;Immunotherapy;improved;in vivo;Incidence;inhibitor;innovation;insight;Institution;Invaded;Leadership;Lung Adenocarcinoma;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Medical;Metabolic;Methods;Modeling;Molecular;Molecular Immunology;molecular pathology;Monitor;multidisciplinary;mutant;Mutate;Mutation;Mutation Detection;Natural Immunity;Nature;New Agents;Non-Small-Cell Lung Carcinoma;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenic;Outcome;patient population;Patients;Peer Review;personalized medicine;personalized therapeutic;Persons;Phase II Clinical Trials;Primary Neoplasm;Program Research Project Grants;programs;Protein Kinase;PTK2 gene;Publications;Publishing;Refractory;Regimen;Regulatory T-Lymphocyte;Research;Research Project Grants;Resistance;resistance mechanism;Resources;response;Role;Signal Transduction;Solid Neoplasm;Source;STK11 gene;Supporting Cell;targeted treatment;Testing;Therapeutic;therapeutic development;therapeutically effective;Translating;tumor;tumor growth;Tumor Immunity;tumor progression;Tumor Suppressor Proteins;tumorigenesis;United States;Universities

PROJECT_TITLE: Deciphering LKB1-associated immunotherapy resistance in lung adenocarcinoma (LUAD)


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative While pancreatic ductal adenocarcinoma (PDAC) is resistant to immune checkpoint blockade (ICB), preventing the formation of the T cell sequestering CXCL12 “coat” renders mouse models of this disease susceptible. This proposal will identify the amino acids of KRT19 required to form the covalent isopeptide bond between it and CXCL12, quantify the rate of CXCL12 coat formation and disassembly, and determine how these processes polarize the immune system. The knowledge gained will guide future pre-clinical and clinical studies attempting to block the formation of the CXCL12 coat in the treatment of PDAC.

PI_NAMEs: MORESCO, PHILIP ANDREW (contact)

PROJECT_TERMS: adaptive immune response;Amino Acids;anti-PD-1;Biochemical Process;Biochemistry;Blocking Antibodies;cancer cell;Cancer Etiology;cancer infiltrating T cells;Carcinoma;Cell Line;Cells;Cessation of life;chemokine;Clinical;Clinical Research;Complex;covalent bond;crosslink;CXC Chemokines;CXCR4 Receptors;Data;Detection;Disease susceptibility;Doxycycline;Educational workshop;Engraftment;Enzymes;extracellular;Failure;Fellowship;fibroblast activation protein alpha;Fibroblasts;functional loss;Future;Generations;Glutamine;Glycocalyx;Goals;Growth;Harvest;Human;Immune;immune activation;immune checkpoint blockade;Immune system;Immunosuppression;In Vitro;in vivo;insight;keratin 12;Keratin-19;Kinetics;Knock-out;Knowledge;Laboratories;laboratory experience;Ligands;Link;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;matrigel;Mediating;Mediator;meetings;mouse model;Mus;mutant;Mutation;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pre-clinical;preclinical study;Predisposition;prevent;Procedures;Process;receptor;Recombinants;Refractory;Repression;Resistance;response;Risk;Scanning;Site;Source;Stains;Stromal Cell-Derived Factor 1;subcutaneous;Surface;Survival Rate;Suspensions;System;T-Lymphocyte;Time;Tissue Stains;Training;transcriptome sequencing;transglutaminase 2;tumor;tumor growth;Tumor Immunity;tumor immunology;United States;Universities;vector;Work

PROJECT_TITLE: Characterizing the biochemistry and dynamics of the immune suppressive CXCL12 coat in pancreatic cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Immunotherapy;Lung;Lung Cancer;Rare Diseases

PHR: PROJECT NARRATIVE Elevated glutaminolysis has been considered as a hallmark of cancer, but the mechanism through which glutaminolysis is upregulated and how it contributes to immunotherapy resistance is largely unclear. We found that glutamate dehydrogenase 1 (GDH1), an essential enzyme in the glutaminolysis pathway, is selectively activated by FAK in LKB1-deficient lung cancer and suppresses anti-tumor immunity via alpha KG-mediated metabolic, transcriptional, and protein stability regulation. In this proposal, we will explore the mechanism by which FAK-mediated GDH1 activation inhibits antitumor immunity specifically in LKB1-deficient lung cancer and validate the therapeutic efficacy of targeting GDH1 in combination with immune checkpoint inhibitors as a novel anti-cancer therapy.

PI_NAMEs: KANG, SUMIN  (contact)

PROJECT_TERMS: Adenocarcinoma Cell;alpha ketoglutarate;Anoikis;anti-cancer;Attenuated;attenuation;Binding;cancer cell;Cancer Control;Cancer Patient;cancer therapy;carcinogenesis;CD8-Positive T-Lymphocytes;Cell Death;Cell Line;Cell Proliferation;Cell Survival;Cells;Cellular Metabolic Process;cofactor;CREB1 gene;Cytometry;efficacy evaluation;Energy Metabolism;Enzymes;Focal Adhesion Kinase 1;Gene Expression;Genetic;Genetic Transcription;Genetically Engineered Mouse;genomic profiling;Glutamate Dehydrogenase;Glutamine;Goals;Homeostasis;Human;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune system;Immunologic Factors;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Infiltration;inhibitor;Invaded;kinase inhibitor;Ligands;Link;Lung Adenocarcinoma;lung cancer cell;Macrophage;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Mitochondria;Mus;mutant;Mutate;Mutation;neoplasm immunotherapy;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Oxidation-Reduction;Pathway interactions;Patients;PD-1 inhibitors;Phosphorylation;Play;poliovirus receptor;Post-Translational Protein Processing;Production;programmed cell death ligand 1;protein expression;Proteins;receptor expression;Receptor Signaling;Regulation;Regulatory T-Lymphocyte;Reporting;Resistance;response;restoration;Role;Signal Transduction;Stimulator of Interferon Genes;STK11 gene;T-Lymphocyte;targeted agent;targeted treatment;Testing;Therapeutic;Toxic effect;transcription factor;Treatment Efficacy;tumor;tumor growth;Tumor Immunity;tumor immunology;tumor progression;Tumor Promotion

PROJECT_TITLE: Project 1: Glutaminolytic GDH1 activation-dependent immunotherapy resistance in LKB1-mutant lung adenocarcinoma


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Clinical Research;Dementia;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: ANN ARBOR

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Balance disorders are common in people with Parkinson's disease and respond poorly to dopaminergic medications. We propose to investigate a novel hypothesis about the effects of cholinergic neurotransmitter changes in specific areas of the brain that are associated with processing of vestibular information and how this relates to balance disorders. Positive findings in the study may result in new treatment strategies to prevent falls in older parkinsonian and non-parkinsonian adults with age-related vestibular changes.

PI_NAMEs: BOHNEN, NICOLAAS IDA (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: acetylcholine transporter;Activities of Daily Living;Acute;Adult;Affect;age related;age related changes;age-related disease;Aging;Agonist;Amygdaloid structure;Area;Attention;Basal Ganglia;Bilateral;Binding;Brain;Brain region;Cell Nucleus;cholinergic;Chronic;Clinical;Cognitive;comorbidity;Data;Dementia;Denervation;Development;Disabling;Dopamine;dopamine transporter;Dopaminergic Agents;equilibration disorder;Equilibrium;Fall prevention;falls;Freezing;Functional disorder;functional loss;Fusiform gyrus;Gait;Geniculate body structure;Goals;human old age (65+);Impaired cognition;Impairment;improved;Inferior;information processing;Insula of Reil;Lateral Geniculate Body;Lobe;Measures;Medial;medial temporal lobe;Methods;Motor;motor symptom;Movement;multimodality;Nerve;neural network;Neurodegenerative Disorders;Neurotransmitters;new therapeutic target;normal aging;novel;novel therapeutic intervention;older adult;Older Population;Parahippocampal Gyrus;Parkinson Disease;Parkinsonian Disorders;Pathologic;Pathology;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Pontine structure;portability;Positron-Emission Tomography;Posture;posture instability;Prevalence;Pulvinar structure;Quality of life;Refractory;Research;Resistance;Rest Tremor;Sensory;Societies;Space Perception;Structure;System;Testing;Thalamic structure;Vestibular Diseases;Vestibular dysfunction;vestibular system;way finding;young adult

PROJECT_TITLE: Central cholinergic presbyvestibulopathy network changes and imbalance in Parkinson's disease and older persons


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences;Sleep Research

ORG_DEPT: PSYCHIATRY

PHR: Neuropeptide S is a neurotransmitter released in the brain to promote wakefulness, but the mechanisms by which it exerts its effects are unknown. Here we will use state of the art methods to map the connections between brain cells that produce Neuropeptide S and the cells known to promote wakefulness. The data generated in this proposal may lead to the development of new treatments for sleep and anxiety disorders.

PI_NAMEs: DE LECEA, LUIS  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Acetylcholine;Acute;Address;Affect;Amygdaloid structure;Anatomy;Anxiety;Anxiety Disorders;anxiety reduction;Architecture;Area;Arousal;Behavior;Behavioral;Body Temperature;Brain;brain cell;Brain region;Breathing;Cell Nucleus;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;combinatorial;CRISPR/Cas technology;Darkness;Data;Development;Dopamine;emotional stimulus;Enterobacteria phage P1 Cre recombinase;Etiology;experimental study;feeding;Fiber;gain of function mutation;Galanin;Gene Mutation;Genetic;Genetic study;Human;hypocretin;improved;Individual;Injections;Internal Ribosome Entry Site;knock-down;Knock-in Mouse;Knockout Mice;Label;Ligands;LoxP-flanked allele;Maps;Medial;Mediating;Messenger RNA;Methods;Motor Activity;Mus;Mutation;Names;Narcolepsy;Neurons;Neuropeptide Gene;Neuropeptide Receptor;Neuropeptides;neuropsychiatric disorder;Neurotensin;neurotransmission;neurotransmitter release;non rapid eye movement;Norepinephrine;novel therapeutics;optogenetics;Pattern;Peptides;Photometry;Physiological;Pontine structure;Population;Process;promoter;Regulation;Reporter;response;Role;Serine;Signal Transduction;Sleep;Sleep Architecture;Sleep Disorders;sleep regulation;Sleep Wake Cycle;Stress;Structure;Subgroup;System;Testing;Thalamic structure;tool;vigilance;Viral;Wakefulness

PROJECT_TITLE: Neuropeptide S and arousal

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

PHR: NARRATIVE Lung cancer is a major cause of cancer death with limited therapeutic options. Lung adenocarcinomas with LKB1 mutations are particularly aggressive and resistant to immunotherapy. This project aims to develop therapeutic strategies to restore tumor sensitivity to immunotherapy through STING activation for LKB1-mutant lung cancer patients.

PI_NAMEs: FU, HAIAN  (contact)

PROJECT_TERMS: Adenocarcinoma Cell;Agonist;antagonist;anti-cancer;Bioinformatics;Biometry;Cancer Etiology;cancer infiltrating T cells;Cancer Patient;cancer therapy;cell killing;Cell Line;Cells;Cessation of life;Chemicals;cIAP1 protein;Clinical;Clinical Trials;Data;Databases;design;Dissection;DNA;Down-Regulation;effective therapy;Effector Cell;Epidermal Growth Factor Receptor;Exhibits;Gene Activation;Gene Expression;gene repression;Genetically Engineered Mouse;Goals;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;Immune system;Immunocompetent;Immunologics;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;inhibitor;inhibitor-of-apoptosis protein;Interferon Type I;Intrinsic factor;IRF3 gene;Isogenic transplantation;JAK1 gene;Leadership;Lung Adenocarcinoma;Malignant neoplasm of lung;Mediating;Modeling;Molecular;molecular targeted therapies;mouse model;Mus;mutant;mutant mouse model;Mutate;Mutation;Natural Immunity;Non-Small-Cell Lung Carcinoma;novel therapeutic intervention;Pathway interactions;Patients;PD-1 blockade;pharmacologic;Phase;Phenotype;pre-clinical;Program Research Project Grants;protein function;protein protein interaction;PTK2 gene;Regulation;Reporting;research clinical testing;Resistance;response;restoration;Role;sample archive;Sampling;screening;sensor;Signal Transduction;small molecule;standard care;STAT1 protein;Stimulator of Interferon Genes;STK11 gene;Subgroup;targeted treatment;TBK1 gene;Testing;Therapeutic;Therapeutic Effect;therapeutically effective;transplant model;Treatment Efficacy;tumor;Tumor Immunity;tumor progression;Tumor Tissue;tumor-immune system interactions;tumorigenesis

PROJECT_TITLE: Project 2: Reversing STING-mediated immunosuppression in LKB1-mutant lung adenocarcinoma


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetics;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

PHR: NARRATIVE LKB1 is ranked as the 3rd most frequently mutated gene in lung adenocarcinoma; however, there are no effective targeted or immunotherapy agents for this patient population. Our goal is to use an inhibitor against FAK to enhance the efficacy of immunotherapy for patients with LKB1-mutant or LKB1-inactivated lung cancer that is tested in a Phase II clinical trial and mechanistically evaluated in pre-clinical models.

PI_NAMEs: MARCUS, ADAM I. (contact)

PROJECT_TERMS: Acceleration;anti-PD-1;anti-PD1 antibodies;Antibody Therapy;cancer cell;Cancer Patient;CD8-Positive T-Lymphocytes;Cell Adhesion;Cell Communication;cell motility;checkpoint therapy;Clinical;clinical development;clinically relevant;cohort;Collagen;Combined Modality Therapy;Data;efficacy evaluation;Fibroblasts;Focal Adhesion Kinase 1;Genes;Genetically Engineered Mouse;Genomics;Goals;immune checkpoint;Immune checkpoint inhibitor;Immunotherapeutic agent;Immunotherapy;improved;inhibitor;inhibitor therapy;Invaded;kinase inhibitor;KRAS2 gene;KRASG12D;Lead;Luciferases;Lung Adenocarcinoma;lymph nodes;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Metastatic Neoplasm to Lymph Nodes;Modeling;molecular targeted therapies;mouse model;Mus;mutant;Mutate;Mutation;Neoplasm Metastasis;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Pathway interactions;patient population;Patients;PD-1 inhibitors;pembrolizumab;pharmacologic;Phase II Clinical Trials;Phenotype;Pilot Projects;Pre-Clinical Model;preclinical trial;prevent;Primary Neoplasm;Publishing;recruit;Regimen;Regulation;Repression;Resistance;response;restoration;Salvage Therapy;STK11 gene;Subgroup;Symptoms;synergism;T cell infiltration;targeted agent;Testing;Therapeutic;Time;tumor;Tumor Burden;tumor growth;tumor progression;Tumor Suppressor Proteins

PROJECT_TITLE: Project 3: Inhibiting FAK to enhance immune checkpoint inhibitor therapy in LKB1-mutant lung adenocarcinoma


NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative Diseases of the gastrointestinal tract, liver and pancreas affect a large proportion of humanity, imposing a major burden on cost, productivity and quality of life. The overreaching goal of the proposed program is to educate a variety of health professionals with a doctorate degree to help improve digestive health in the population al large. By expanding the number of physicians and investigators the program will foster the discovery of new and more effective forms of treatment for digestive diseases.

PI_NAMEs: COMINELLI, FABIO ;FIOCCHI, CLAUDIO  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Digestive System Disorders;Science;Training Programs

PROJECT_TITLE: Combined Training Program in Digestive Disease Sciences


NIH_SPENDING_CATS: Cancer;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

PHR: NARRATIVE The Administrative Core 1 is vital for the overall direction, integration and administrative activities of all the program Projects and Cores. This Core will provide oversight and coordination of all P01 activities, maintain fiscal oversight and ensure compliance with all regulations. Core 1 will also oversee the evaluation of Project and Core progress, guided by Internal and External Advsiory Committees and an Executive Committee.

PROJECT_TERMS: Advocate;Award;Basic Cancer Research;Bioinformatics;Biology;Biostatistics Core;Cancer Center;Clinical Investigator;clinical translation;Clinical Trials;Collaborations;Communication;Consultations;Data;data quality;Decision Making;Ensure;Ethics;Evaluation;Evaluation Research;experience;experimental study;Funding;Future;Goals;Grant;Human Resources;Immunotherapy;improved;Individual;Institution;interdisciplinary approach;Interdisciplinary Study;Leadership;lectures;Lung Adenocarcinoma;Maintenance;Malignant neoplasm of lung;meetings;member;Monitor;National Cancer Institute;Office of Administrative Management;operation;Patients;Performance;Policies;Preparation;Procedures;Productivity;Program Research Project Grants;programs;Progress Reports;quality assurance;Quality Control;Recommendation;recruit;Regulation;remediation;Reporting;Research;Resistance;Resource Sharing;Resources;Schedule;Science;STK11 gene;Strategic Planning;success;symposium;Therapeutic;Training;Translating;United States National Institutes of Health;Universities

PROJECT_TITLE: Core 1:  Administration


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Neurosciences

ORG_CITY: GREER

ORG_NAME: NUBAD, LLC

ORG_STATE: SC

PHR: The work proposed here, a multidisciplinary effort to improve the therapeutic index of a well-established class of drugs-the aminoglycosides. We propose to reduce their ototoxicity, while simultaneously improving the anti- infective effects. In vitro and in vivo ototoxicity studies will be used to optimize the development of a new class of small molecules developed by NUBAD as non-toxic therapeutics. The success of the proposed work would be a significant addition to currently available classes of aminoglycosides in broad spectrum drug development. Using our preliminary data, we propose using our promising leads to develop and optimize a small library of small molecules that can be employed to inhibit microbial growth but with significantly lower ototoxicities, opening possibilities for development of therapeutics with improved therapeutic profiles over existing clinical standard of care drugs. The proposed research describes such a strategy for improving the therapeutic index of aminoglycosides by designing novel structures that lower their ototoxicities.

PI_NAMEs: STORY, SANDRA PAIGE (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: absorption;Acute;acute infection;Address;Affect;Aminoglycoside Antibiotics;aminoglycoside-induced ototoxicity;Aminoglycosides;Anti-Bacterial Agents;anti-fungal agents;Anti-Infective Agents;Antibiotics;Apical;Auditory;Auditory Brainstem Responses;Bacteria;Bacterial Infections;bacterial resistance;base;Biodistribution;Biological;Biological Assay;Biological Availability;Biology;Candida;candidate identification;Candidiasis;Cavia;Cell Death;Cell Wall;Cells;Chemistry;Clinic;Clinical;Cochlea;combat;Containment;cost;Creativeness;cystic fibrosis patients;Data;design;Detection;Development;disability;Disease;Dose;drug development;Drug Interactions;Drug Kinetics;Drug toxicity;economic cost;efficacy study;Equilibrium;Event;Excretory function;Feedback;follow-up;Fungal Drug Resistance;Generations;Growth;guinea pig model;Hair Cells;Health;Health Care Costs;hearing impairment;Human;Immunocompromised Host;improved;In Vitro;in vivo;Incidence;Individual;Infection;inhibitor;innovation;interest;Knowledge;Labyrinth;Lead;Legal patent;Lethal Dose 50;Libraries;Lipids;Liver Microsomes;Measurement;mechanical stimulus;Mechanoreceptors;Medical;Metabolic;Metabolism;method development;Methods;Microbe;microbial;Microbial Biofilms;Minimum Inhibitory Concentration measurement;Modeling;Modification;mouse model;multidisciplinary;Mus;Mycoses;National Institute of Allergy and Infectious Disease;Natural regeneration;nephrotoxicity;Nosocomial Infections;novel;novel therapeutic intervention;novel therapeutics;Organ;Organ Culture Techniques;ototoxicity;pathogen;Pathologic;Pathway interactions;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Pharmacodynamics;Phase;Population;pre-clinical;pre-Investigational New Drug meeting;preclinical toxicity;preference;prevent;Prevention therapy;Protocols documentation;Pseudomonas;Quality of life;Rapid screening;rapid technique;Renal function;Research;Resistance;Resistance profile;Risk-Benefit Assessment;RNA Binding;Role;screening;screening program;Sensory Hair;Series;Serum;side effect;Signal Transduction;small molecule;small molecule libraries;Solid;sound;South Carolina;standard of care;Structure;success;synergism;Testing;Therapeutic;therapeutic development;Therapeutic Index;Time;Tobramycin;Toxic effect;Tuberculosis;tuberculosis treatment;United States National Institutes of Health;Universities;Vestibular Diseases;vestibular system;Work

PROJECT_TITLE: Ototoxicity of modified aminoglycosides


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Rare Diseases

PHR: NARRATIVE The Molecular Pathology and Immunology Core 2 will collect and store tissues from patients with lung cancer, and will characterize these tissues using pathologic, genomic and immunologic tests. The Core will provide the tissues and the associated clinical, pathological, immunologic and genomic information to the investigators of all three of the proposed translational projects and to the biostatistics core for integration into a specialized lung cancer P01 database. These studies will help us understand lung cancer better and potentially allow us to develop new treatments for about one quarter of all lung adenocarcinoma patients whose tumors carry LKB1 mutations.

PI_NAMEs: DHODAPKAR, KAVITA MADHAV (contact)

PROJECT_TERMS: Anatomy;Archives;Bioinformatics;Biological;Biological Assay;Biopsy;Biostatistics Core;Blood;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;central database;Clinical;clinical practice;clinical trial protocol;Clinical Trials;Communication;Consent;Correlative Study;Coupled;Culture Media;Cytometry;Data;data integration;data sharing;Database Management Systems;Databases;Diagnosis;digital;Ensure;Ethics;Evaluation;experience;Fluorescence;Freezing;Gene Expression;genomic data;Genomics;Goals;Histologic;Histology;Histopathology;human tissue;IACUC;Image;Immune;Immune response;Immune system;Immunohistochemistry;Immunologic Monitoring;Immunologic Tests;Immunologics;Immunologist;Immunotherapy;Infrastructure;Institutional Review Boards;Investigation;Liquid substance;Lung;Lung Adenocarcinoma;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Molecular Immunology;molecular pathology;Monitor;mouse model;Mutation;neoplastic;Nursing Research;Pathologic;Pathologist;Pathology;Patients;Phenotype;preclinical study;Procedures;Process;prospective;Proteomics;Protocols documentation;Quality Control;repository;Research;Research Personnel;Resistance;Resource Sharing;Resources;Saliva;Sampling;Scientist;Secure;Services;single-cell RNA sequencing;Slide;Specific qualifier value;Specimen;Specimen Handling;Stains;Standardization;STK11 gene;Structure;System;Technical Expertise;Tissue Banks;Tissue Sample;Tissues;tool;Translations;tumor;Tumor Markers;Tumor-infiltrating immune cells;Update;Work

PROJECT_TITLE: Core 2


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NORMAN

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: Project Narrative (Overall Center) Structural biology lies at the intersection of many different areas of biological sciences. The Oklahoma COBRE in Structural Biology (OCSB) supports research projects that utilize a structural approach to gain insight into the basis of human diseases. The OCSB has established and supported scientific core facilities that enable investigators to use structural biology approaches to address biomedically important research areas that will lead to new therapeutic strategies.

PI_NAMEs: WEST, ANN H (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Address;Area;Award;base;Biological Sciences;biophysical analysis;biophysical properties;career;Centers of Research Excellence;Client;Communities;Consultations;Core Facility;Cryoelectron Microscopy;Crystallization;Data Collection;Development;Education;Educational workshop;experience;Faculty;faculty support;Fees;Freezing;Funding;Goals;Grant;Group Meetings;Health Sciences;human disease;insight;Institution;instrumentation;Interdisciplinary Study;Location;macromolecule;Mentors;mid-career faculty;Mission;Molecular Structure;novel therapeutic intervention;Oklahoma;outreach;Paper;Peer Review;Phase;Pilot Projects;Postdoctoral Fellow;posters;Preparation;Production;programs;protein expression;protein purification;Proteins;Publishing;Research;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;Roentgen Rays;Sampling;Series;Services;structural biology;Structure;Students;symposium;Training;Training and Education;Universities;Visit

PROJECT_TITLE: Oklahoma COBRE in Structural Biology


NIH_SPENDING_CATS: Cancer;Clinical Research;Data Science;Immunotherapy;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Orphan Drug;Rare Diseases

PHR: NARRATIVE The Bioinformatics and Biostatistics Core (Core 3) will serve as a focal point to provide comprehensive biostatistical resource, to provide a new integrative computational platform to support the elucidation of roles of GDH1, IAP/STING, and FAK in LKB1-deficient LUAD, and to develop and maintain a centralized data acquisition and management system. Core 3 will allow investigators across all P01 projects and cores to have a formalized, ongoing and collaborative interaction and arrangement with three key expertise areas in biostatistics, medical informatics, and bioinformatics.

PI_NAMEs: LIU, YUAN  (contact)

PROJECT_TERMS: Address;anti-cancer;Area;Basic Science;Bioinformatics;Biological;Biological Process;Biometry;Biostatistics Core;cancer information system;Cells;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;Communication;computational platform;Critical Thinking;Data;data acquisition;Data Analyses;data exchange;data integration;data integrity;data management;Data Management Resources;data sharing;design;Development;Dimensions;Elements;Ensure;experience;Experimental Designs;Fostering;Genes;Goals;Immunotherapy;Information Systems;Infrastructure;innovation;laboratory experiment;Lung;Lung Adenocarcinoma;lung cancer cell;Malignant neoplasm of lung;Manuscripts;Medical;Medical Informatics;member;Methodology;Molecular;Molecular Immunology;molecular pathology;Monitor;multidisciplinary;Mutate;next generation;novel;Pathway interactions;Patients;Phase;Preparation;Program Research Project Grants;programs;prospective;Protocols documentation;PTK2 gene;Reporting;Reproducibility;Research;Research Activity;Research Personnel;Research Project Grants;Resistance;resistance mechanism;Resources;Role;Sampling;Secure;shared database;Statistical Data Interpretation;STK11 gene;success;Systems Biology;Therapeutic;translational study;Tumor Immunity;tumorigenesis;Work

PROJECT_TITLE: Core 3: Bioinformatics and Biostatistics Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Precision Medicine;Prevention

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE STATEMENT Alzheimer’s disease and related dementias have a devastating impact on public health and patient function, and interventions to slow cognitive decline or reduce risk of developing dementia are desperately needed. There is a strong link between visual impairment and cognitive impairment or risk of dementia; we hypothesize that cataract surgery—a widely available intervention to improve vision—may be able to “bend the curve” for risk of dementia onset and worsening. This study will use existing large-scale electronic health record data to investigate the impact of cataract surgery and visual impairment on incidence and progression of dementia in a real-world setting, which will enable a subsequent clinical trial and other dementia research for a more precise approach to treating individual patients.

PI_NAMEs: PERSHING, SUZANN  (contact)

PROJECT_TERMS: Acceleration;Affect;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Archives;Benefits and Risks;Biometry;Caregivers;Cataract;Cataract Extraction;Characteristics;Classification;Clinical;Clinical Trials;Clinical Trials Design;Cognitive;cognitive function;cognitive testing;Contrast Sensitivity;Cox Proportional Hazards Models;Data;Data Set;Delirium;Dementia;dementia risk;Electronic Health Record;Electronics;Epidemiology;Eye diseases;Eyeglasses;Family;Foundations;Goals;hazard;Healthcare Systems;high risk;Home Nursing Care;Impaired cognition;Impairment;improved;Incidence;individual patient;Informatics;Institution;Intervention;Investigation;Link;Longitudinal Studies;Machine Learning;machine learning prediction;Mediator;Methods;mild cognitive impairment;model generalizability;Modeling;Natural Language Processing;neurosensory;open source;Operative Surgical Procedures;Ophthalmology;Outcome;Outcomes Research;Patient Selection;patient stratification;patient subsets;Patient-Focused Outcomes;Patients;Phenotype;Pragmatic clinical trial;precision medicine;predictive modeling;prevent;Provider;Public Health;public health relevance;Research;Resources;Risk;Risk Reduction;Sensory Deprivation;Severities;sex;shared decision making;social engagement;standard of care;Structure;structured data;Symptoms;Testing;Text;Time;unstructured data;Veterans Health Administration;Vision;Visual;Visual Acuity;visual deprivation;Visual impairment;visual information;visual processing;Work

PROJECT_TITLE: Using Informatics to Evaluate and Predict Cataract Surgery Impact on Alzheimer's Disease and Related Dementias and Mild Cognitive Impairment Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(55)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Address;Advisory Committees;Air;Award;base;Businesses;Centers of Research Excellence;Communication;Communities;community building;Core Facility;Development Plans;Education and Outreach;Educational Activities;Educational workshop;Ensure;experience;Faculty;Feedback;Funding;Future;Goals;Group Meetings;Incentives;Leadership;Mentors;Monitor;next generation;Occupational activity of managing finances;Oklahoma;operation;Pilot Projects;Policies;Preparation;Procedures;Productivity;programs;Progress Reports;Reporting;Research;Research Personnel;Research Project Grants;Series;Structural Biologist;structural biology;Techniques;Training;Update;Work;Writing

PROJECT_TITLE: Adminstrative Core


PI_NAMEs: BOURNE, PHILIP CHARLES (contact)

PROJECT_TERMS: Advisory Committees;Applications Grants;Award;base;Biological Sciences;biophysical properties;Centers of Research Excellence;Collaborations;Communities;Core Facility;cost;Cryoelectron Microscopy;Crystallization;Data;Educational workshop;Equipment;Faculty;Fee-for-Service Plans;Fostering;graduate student;Grant;Individual;innovation;instrumentation;Laboratories;Laboratory Research;Learning Module;macromolecule;Maintenance;Mass Spectrum Analysis;metabolomics;Methodology;Microscopy;Molecular;Names;next generation;Oklahoma;outreach;Peer Review;Phase;posters;Production;protein expression;protein purification;protein structure;Proteins;Proteomics;Protocols documentation;Publications;Research;Research Infrastructure;Research Personnel;Research Support;Resources;Scientist;Services;structural biology;Structure;symposium;Techniques;Technology;Training;Universities;Work

PROJECT_TITLE: Protein Production and Characterization Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Opioid therapy is controversial due to risks for misuse and dependence; yet, many patients continue to advocate for and use opioids at the cost of high rates of continued exposure and soaring national rates of opioid addiction and overdose deaths. This project will evaluate the neurobiological consequences of opioids, in particular how central nervous system (CNS) activity is altered in patients on long-term opioid therapy, a research focus which to date, has been remarkably neglected. The knowledge gained through this work will inform novel CNS-based strategies for effective alternatives to opioid therapy, avenues to reverse deleterious neurobiological consequences of opioid therapy, and treatments to aid in opioid cessation and to combat drug addiction.

PI_NAMEs: MARTUCCI, KATHERINE THERESA (contact)

PROJECT_TERMS: Absence of pain sensation;addiction;Address;Advocate;Affect;Affective;Analgesics;Attenuated;Behavior;Behavioral;Blood;Brain;brain based;Brain region;Central Nervous System;Cervical spinal cord structure;Clinical;clinical pain;Clinical Trials;Cognition;Cognitive;combat;cost;Data;Dependence;design;dorsal horn;Dose;Drug Addiction;fibromyalgia patients;financial incentive;Functional Magnetic Resonance Imaging;Funding;Future;Goals;heat stimulus;Human;Hyperalgesia;Impairment;improved;innovation;Knowledge;Measures;Medial;Motivation;National Institute of Drug Abuse;neglect;neural circuit;Neurobiology;neuroimaging;novel;Nucleus Accumbens;Opiate Addiction;Opioid;opioid epidemic;opioid mortality;opioid therapy;opioid use;opioid use disorder;opioid user;overdose risk;Pain management;Patients;patients who use opioids;Prefrontal Cortex;Probability;Psychology;Publishing;Reporting;Research;Resolution;response;Rest;reward anticipation;reward circuitry;Rewards;Risk;Sampling;Sensory;side effect;Spinal;Spinal Cord;Spinal cord posterior horn;Stimulus;Strategic Planning;System;Testing;women patients;Work

PROJECT_TITLE: Neurobiological Consequences of Long-Term Opioid Therapy in the Brain and Spinal Cord

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


PI_NAMEs: THOMAS, LEONARD M (contact)

PROJECT_TERMS: Award;base;Biological Process;Centers of Research Excellence;Collaborations;Collection;Communities;Competence;Complex;computer infrastructure;computerized data processing;computing resources;Consult;Cryoelectron Microscopy;Crystallization;Crystallography;Data;Data Collection;Deposition;design;detector;Development;Doctor of Philosophy;drug candidate;Education and Outreach;Educational workshop;Ensure;Equipment;Faculty;Fees;Freezing;Funding;Geography;graduate student;Grant;Group Affiliation;Growth;Health;Health Sciences;Human;human disease;Hybrids;improved;insight;Institution;instrument;instrumentation;interest;Knowledge;Laboratories;literacy;Literature;macromolecule;Methodology;Methods;Microscopy;Molecular;molecular dynamics;molecular modeling;Molecular Structure;next generation;novel therapeutics;Nucleic Acids;Oklahoma;Outcome;Output;Peer Review;Phase;Play;Postdoctoral Fellow;Preparation;prevent;Process;programs;protein data bank;Proteins;Publications;Qualifying;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resolution;Resources;Robotics;Roentgen Rays;Role;sample collection;Sampling;Scientist;screening;Services;Specialist;Structural Biologist;structural biology;Structure;Students;Synchrotrons;Techniques;Therapeutic;three dimensional structure;Three-dimensional analysis;Time;Training;undergraduate student;Universities;Work;X-Ray Crystallography

PROJECT_TITLE: Biomolecular Structure Core


PROJECT_TERMS: Applications Grants;Award;base;Centers of Research Excellence;Collaborations;Core Facility;Cryoelectron Microscopy;Data;experience;Funding;Funding Opportunities;Grant;Incentives;innovation;interest;Investments;Mentorship;Oklahoma;Participant;Phase;Pilot Projects;programs;Publications;Research;Research Personnel;Structural Biologist;structural biology;success;Techniques;Training

PROJECT_TITLE: Pilot Project Program


NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Health Services;Lung

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Up to one million Americans undergo invasive mechanical ventilation each year and are subject to high rates of morbidity and mortality. These patients are cared for by a team of clinicians, including physicians, nurses, and respiratory therapists; however, the role that each clinician group plays in determining patient outcomes is unknown. This project will explore how different types of clinicians contribute to patient outcomes individually and as teams, thereby creating new knowledge that can inform strategies and policies to improve care of this high-risk patient population.

PI_NAMEs: KERLIN, MEETA PRASAD (contact)

PROGRAM_OFFICER_NAME: STEFAN, MIHAELA STEFANIA

PROJECT_TERMS: Accounting;Acute;acute care;Adherence;American;brain dysfunction;Care given by nurses;Caring;Characteristics;Clinical;cohort;Collaborations;cost;Critical Illness;Discipline of Nursing;Dose;Economic Models;economic outcome;Economics;Effectiveness;evidence base;Future;Health system;high risk;high risk population;hospital care;Hospital Mortality;Hospitals;improved;improved outcome;Individual;individual patient;innovation;Institution;Intensive Care Units;Interdisciplinary Study;International;Intervention;Interview;K-Series Research Career Programs;Knowledge;Length of Stay;Measurement;Measures;Mechanical ventilation;member;Mentors;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;nurse performance;Nurses;Outcome;Patient Admission;Patient Care;patient population;Patient-Focused Outcomes;Patients;Pennsylvania;Performance;Physician's Role;Physicians;Play;Policies;Population;Process;programs;provider factors;Recommendation;Research;Resources;respiratory;Retrospective cohort study;Risk Adjustment;Role;Sampling;Science;Scientist;Sedation procedure;sedative;Societies;Standardization;statistics;Structure;team-based care;Techniques;Testing;Time;tool;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Economic modeling to understand the relationship between clinicians and outcomes of mechanically ventilated patients


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative This study takes advantage of unique camera technology developed in my laboratory for live imaging of cells in the human retina. We will use this camera to investigate how the retina's light‐capturing cells contribute to our vision and how they are affected by retinitis pigmentosa, the most common form of inherited irreversible vision loss. Results of this study may help improve our ability to detect and treat some of the most blinding diseases in the world.

PI_NAMEs: MILLER, DONALD T (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: 3-Dimensional;adaptive optics;Affect;Algorithms;Anatomy;Blindness;cell type;Cells;Clinic;Color;Color Visions;Complex;Cone;Custom;Data;Detection;Disease;Early Diagnosis;Early treatment;Electrophysiology (science);Electroretinography;Eye;gene replacement therapy;genetic testing;Genotype;Goals;Grant;Human;Image;image registration;improved;in vivo;Individual;Inherited;instrumentation;Investigation;Laboratories;Length;Light;light scattering;live cell imaging;Measurement;Measures;Mediating;Methods;Modality;Monitor;mosaic;neural;neuroprotection;Optical Coherence Tomography;Optical Methods;Optics;Outcome;Patients;Phase;Phenotype;Photoreceptors;Physiological;Physiological Processes;Process;Process Assessment;Property;Psychophysics;Red-Green Color Blindness;Research;Resolution;response;Retina;Retinal Cone;Retinal Degeneration;retinal rods;Retinitis Pigmentosa;Safety;Specificity;stem cell therapy;Structure;System;Techniques;Technology;Testing;therapy development;Tissues;tool;treatment trial;Vision;X Inactivation

PROJECT_TITLE: Imaging Structure and Function of Photoreceptors


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Prevention

ORG_CITY: MONTREAL

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: SAINTE-JUSTINE UNIVERSITY HOSPITAL CTR

ORG_STATE: PQ

PHR: Project Narrative Copy number variants are a class of genetic mutations, which are associated with greatly elevated rates of major psychiatric disorders such as autism and schizophrenia. We propose to assemble the largest neuroimaging and genomic dataset to date (total of 140,000 individuals) to identify mechanisms that mediate the effects of deletions and duplications on brain structure and function.

PI_NAMEs: BEARDEN, CARRIE E;JACQUEMONT, SEBASTIEN  (contact);THOMPSON, PAUL M

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Address;Algorithms;Architecture;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavioral;Brain;brain behavior;Brain Diseases;Brain imaging;Canada;case control;Clinic;Clinical;clinically relevant;Code;Cognition;cohort;Copy Number Polymorphism;Data;Data Aggregation;Data Set;Development;Diffusion Magnetic Resonance Imaging;Dimensions;disorder risk;DNA;DNA Sequence Alteration;Functional Magnetic Resonance Imaging;gene function;General Population;Genes;Genetic;Genetic Diseases;Genetic Predisposition to Disease;genetic variant;Genetic Variation;genome-wide analysis;genomic data;Heterogeneity;Image;Individual;Intelligence;Knowledge;Link;Loneliness;Magnetic Resonance Imaging;Maps;mathematical model;Measures;Mediating;Medical;Mental disorders;Methods;Modality;Molecular;multidisciplinary;multimodal neuroimaging;neural;neurodevelopmental effect;neurogenetics;neuroimaging;Neurotic Disorders;Norway;Participant;patient subsets;Pattern;Pediatric Hospitals;Personality Traits;Phenotype;polygenic risk score;Population;population based;postnatal;prenatal;Process;Psychopathology;Psychoses;psychotic;Recurrence;Research Domain Criteria;Rest;Risk;risk variant;Sample Size;Schizophrenia;Site;social;Statistical Models;structural imaging;Structure;Surface;Symptoms;Testing;Training;trait;Variant;Work

PROJECT_TITLE: Understanding Rare Genetic Variation and Disease Risk: A Global Neurogenetics Initiative

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Psychosis;Schizophrenia;Serious Mental Illness;Substance Misuse;Telehealth

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: PROJECT NARRATIVE Having a co-occurring substance use disorder is common in and a significant predictor of treatment dropout for individuals with first episode psychosis (FEP). Reducing substance use in this vulnerable co-occurring disorders population is an unmet need that requires novel interventions to improve engagement in substance use elements of integrated psychiatric care. The present research project will iteratively develop and pilot test a highly accessible version of a well-established substance use disorder treatment engagement strategy, Community Reinforcement Approach and Family Training, targeting family members of people with co-occurring substance use disorders and FEP and delivered via telemedicine (CRAFT-FT) to assess changes in substance use disorder treatment engagement, substance use, and family distress compared to treatment as usual and in-person CRAFT-F.

PI_NAMEs: MCCARTHY, JULIE M. (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: addiction;Address;Alcohol consumption;Anxiety;Area;arm;Attenuated;barrier to care;Biological;career;Child Care;Client;Clinical;clinical practice;Clinical Research;Clinical Trials;Communication;Communities;Data;Dedications;design;Development;Diagnosis;Diagnostic;Distress;Dropout;dual diagnosis;Educational Intervention;Elements;Evidence based treatment;experience;Family;Family member;Feedback;first episode psychosis;Focus Groups;Goals;Happiness;improved;Individual;innovation;Intervention;Intervention Studies;Interview;Leadership;longitudinal analysis;Manuals;marijuana use;Measures;Mental disorders;Mentors;Mentorship;Moods;Motivation;novel;novel strategies;open label;Outcome;Participant;Patient Self-Report;Patients;Persons;pilot test;Population;Prediction of Response to Therapy;preference;Protocols documentation;Psychiatric therapeutic procedure;Psychological reinforcement;Psychoses;psychosocial;Psychotherapy;Psychotic Disorders;randomized, clinical trials;Randomized, Controlled Trials;Readiness;Recommendation;Recording of previous events;reduced substance use;Research;Research Personnel;Research Project Grants;Role;Services;skills;Statistical Methods;substance use;Substance Use Disorder;substance use treatment;Technology;Telemedicine;Testing;therapy development;Time;Tobacco use;tool;Training;Transportation;treatment adherence;treatment as usual;Treatment outcome;treatment research;treatment risk;Urine;usability;Videoconferencing;Vulnerable Populations

PROJECT_TITLE: Improving Treatment Engagement in Individuals with Co-occurring Substance Use and Psychosis: A Telemedicine Family-Based Approach

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: 8. PROJECT NARRATIVE  This training grant contributes to the replenishment of specialists, both MD and PhD, in a number of topical areas of national health priorities. These include, but are not restricted to, diabetes, obesity, cardiovascular disease, women’s health, and behavioral medicine. It is a high quality and highly structured program, supported by an outstanding training faculty and exceptional institutional resources at one of the premier medical research campuses in the US. Over its long history (>46 years) it has been very successful in training outstanding fellows for research and research-related positions in academia and other research settings, as defined by the NIH.

PI_NAMEs: O'DOHERTY, ROBERT M (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TITLE: T32 Research Training in Diabetes and Endocrinology


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Gene Therapy;Genetics;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

PHR: Public Health narrative Gene therapy allows for production of therapeutic proteins by patients' own cells. However, once the gene therapy is administered to the body of a large animal or a human, we have no methods of measuring how well the gene therapeutic is expressed, or whether it has reached the correct cells. Here, we are developing new technologies that will enable such measurements with a simple and convenient blood test.

PI_NAMEs: SZABLOWSKI, JERZY OLGIERD (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Address;adenovirus mediated delivery;Animals;Area;Autopsy;Bacterial Proteins;Biochemical;Biological Markers;Biological Models;Blood;Blood Circulation;Blood Tests;blood-brain barrier permeabilization;Brain;brain cell;Brain Diseases;Brain imaging;Brain Injuries;Brain region;brain size;cell type;Cells;Cerebrovascular system;Characteristics;Chemicals;Color;cranium;Cytochrome P450;Democracy;design;Detection;Development;Diffusion;Disease;Engineering;Equipment;Euthanasia;Eye;Ferritin;Focused Ultrasound;FOS gene;Future;Gene Delivery;Gene Expression;Gene Expression Profiling;gene therapy;Genes;Goals;Histology;Human;Image;Imaging Device;Immobilization;immunogenic;improved;in vivo;interstitial;Kinetics;Label;Laboratory Research;Light;Luciferases;Magnetic Resonance Imaging;Measurement;Measures;Methods;millimeter;Molecular;Monitor;Mus;Neurons;new technology;non-invasive monitor;Optical Methods;Organ;Organ Size;Patients;Penetration;Physiological;Process;Production;promoter;protein biomarkers;Public Health;Reporter;Reporting;Research;sensor;Serum;side effect;Signal Transduction;Site;Specificity;Spinal Cord;Structure;Technology;Testing;therapeutic gene;therapeutic protein;Thick;Time;Tissues;Toxic effect;transcytosis;transgene expression;Translations;ultrasound;Vascular Permeabilities;Work

PROJECT_TITLE: Noninvasive site-specific measurement of gene expression in deep tissues with secreted reporters

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]