ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: NARRATIVE Mg2+ is essential for wide range of cellular processes including the imposition of membrane shape and stability, neutralization and stabilization of nucleic acids and nucleotides, channel modulation, enzyme secretion from acinar cells, and serves as a cofactor for cytosolic and mitochondrial metabolic enzymes. Although cellular Mg2+ dynamics is accomplished via numerous Mg2+ transport machineries, the molecular identity of these Mg2+ flux mechanisms have not been fully elucidated. In the MIRA program, we will identify ligands and channels and elucidate Mg2+-dependent metabolic signals that would establish the Mg2+ flux compendium.

PI_NAMEs: MUNISWAMY, MADESH  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acinar Cell;Binding;Biochemical Reaction;Bioenergetics;Biological;Biophysics;Buffers;Cations;Cell membrane;Cell model;Cell Physiology;Cells;Cellular biology;cofactor;Complex;CRISPR/Cas technology;Cytosol;Deficiency Diseases;Dissociation;Endosomes;Enzymes;Equilibrium;Event;Functional disorder;Funding;Future;Homeostasis;Hormonal;Ion Channel;ionization;Laboratories;Ligands;Link;Lysosomes;Magnesium;Membrane;Metabolic;Metabolism;MgATP;Mitochondria;Mitochondrial Matrix;Molecular;mouse model;Nucleic Acids;Nucleotides;Organelles;Phenotype;Physiological;programs;Proteins;Rest;RNA interference screen;Role;Route;Shapes;Signal Pathway;Signal Transduction;Stimulus;Testing;uptake;Work

PROJECT_TITLE: Magnesium flux compendium: Discover ligands, channels, and metabolic signals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Spatial navigation is fundamental to survival, and entorhinal cortex (EC) function is fundamental to remembering cognitive maps of environments, and perhaps in mapping relationships between knowledge more generally. EC dysfunction is one of the earliest effects of Alzheimer’s disease, yet how EC contributes to the cognitive mapping abilities that are impacted in aging and Alzeheimer’s-related dementia is remarkably poorly understood. We will utilize cutting-edge neuroimaging and virtual reality techniques to test specific predictions about how EC supports the cognitive map in young adults, and apply this foundational knowledge in an aged cohort to test a deep, mechanistic perspective of age-related declines in goal-directed navigation.

PI_NAMEs: BROWN, THACKERY IAN (contact)

PROGRAM_OFFICER_NAME: THOMAS, CIBU PAUL

PROJECT_TERMS: Address;Age;age difference;age related;age related changes;age related decline;age-related disease;aged;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;apolipoprotein E-4;Biological Markers;Brain;Cells;Code;Cognition;Cognitive;cohort;Communication;Complex;Computer Models;Data;Dementia;design;entorhinal cortex;Environment;Euclidean Space;experience;experimental study;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Geometry;Goals;graph theory;healthy aging;Hippocampus;Human;Hybrids;Impaired cognition;Impairment;Individual;insight;Intervention;Knowledge;Learning;Life;Link;Literature;Location;Machine Learning;Maps;Measures;member;Memory;Methods;mild cognitive impairment;Modeling;Motion;neural;neuroimaging;neuromechanism;Neurons;Nobel Prize;novel;Pattern;Performance;Persons;pre-clinical;preference;programs;psychologic;Research;Research Personnel;Rodent;Route;segregation;Shapes;Signal Transduction;Space Perception;spatial memory;spatial relationship;statistical learning;Structure;System;Techniques;Testing;theories;Time;Update;virtual;virtual reality;Visual Cortex;way finding;Work;young adult

PROJECT_TITLE: Influences of Environmental Geometry and Aging on Cognitive Mapping Mechanisms

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_CITY: DAVIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative (Public Health Relevance) Protein synthesis on the ribosome and intracellular motility and cell division, based on the molecular motors are crucial for development and maintenance of all of the organs in the body. The specific cellular machines to be studied here, the ribosome, myosins, and cytoplasmic filaments, are required for appropriate neuronal development, sensorineural function in hearing and eyesight, the immune response and cell division. Thus errors of expression or function lead to severe developmental neurological, cardiovascular, immunological deficits, and play roles in cancer cell division and metastasis, muscular dystrophy, cystic fibrosis and many other diseases. The studies proposed here will give fundamental information on how gene expression, cellular development, and transport motors function and may eventually lead to therapeutic targets in these diseases.

PI_NAMEs: GOLDMAN, YALE E (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Active Biological Transport;Amyloid Proteins;Biochemical;Biophysical Process;biophysical techniques;biophysical tools;cancer cell;Cardiovascular system;Cell division;Cell Nucleus;Cells;Cellular biology;cellular development;Characteristics;Cystic Fibrosis;Cytoplasmic Filaments;Defect;Development;Disease;Duchenne muscular dystrophy;Environment;Eukaryota;Fluorescence;Fluorescence Resonance Energy Transfer;Gene Expression;Grant;Hearing;Immune response;Immunologics;In Vitro;Individual;katanin;Kinetics;Lead;Length;Link;Literature;Maintenance;mechanical force;mechanical properties;Methods;Microtubules;molecular dynamics;Molecular Motors;Motility;Motor;Muscle;Muscular Dystrophies;Myosin ATPase;Myosin Type I;Neoplasm Metastasis;Nerve Degeneration;Neurologic;neuron development;non-muscle myosin;nucleoside triphosphatase;optic trap;optical traps;Organ;Organelles;Peripheral;Pharmacologic Substance;Pigmentation physiologic function;Play;premature;programs;Property;Protein Biosynthesis;protein expression;Protein Isoforms;protein transport;Proteins;public health relevance;Reaction;Ribosomes;Role;sensor;Series;Signal Transduction;Signaling Molecule;single molecule;Skeletal Muscle Myosins;synergism;System;targeted delivery;Technology;Terminator Codon;Testing;therapeutic target;Tissues;tool;United States National Institutes of Health;vesicle transport

PROJECT_TITLE: "Structural Dynamics of Molecular Motors and the Ribosome" The studies proposed will give basic information on gene expression, cellular development, and transport motor function in cell biology.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: MH

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Dissemination and Implementation Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Despite strong consensus that early, specialized intervention for children with Autism Spectrum Disorder (ASD) can have a dramatic impact on outcomes, the public health system’s capacity to provide such services is severely challenged by the rapid rise in ASD prevalence. The goal of this research is to increase timely and equitable access to ASD-specialized early intervention during the critical first three years of life by capitalizing on the existing infrastructure of the Part C Early Intervention (EI) system, which is publicly funded and available in all U.S. States. This project will train EI providers to use an evidence-based, inexpensive, parent-mediated intervention that can improve child and family outcomes as well as mitigate the substantial economic costs associated with ASD.

PI_NAMEs: STONE, WENDY L. (contact)

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: acceptability and feasibility;Address;Aftercare;Age;Area;autism spectrum disorder;autism symptoms;autistic children;Behavior;Behavior Therapy;Birth;Characteristics;Child;Child Language;Child Rearing;clinically relevant;Code;Consensus;Consensus Development;Consultations;Data;data management;Development;Developmental Delay Disorders;Developmental Disabilities;dosage;Early Intervention;economic cost;Educational process of instructing;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation design;effectiveness/implementation hybrid;Equity;evidence base;Evidence based intervention;Family;Family member;follow-up;Funding;Future;Goals;Health system;Heterogeneity;Home;hybrid type 1 design;Hybrids;implementation determinants;implementation evaluation;improved;improved outcome;Individuals with Disabilities Education Act;Infrastructure;innovation;Intervention;intervention program;Interview;joint attention;Language;Language Development;language outcome;Lead;Learning;Life;Measures;Mediating;member;Methods;Modification;Motor;multi-site trial;National Institute of Mental Health;Outcome;Parents;Patient Self-Report;Personal Satisfaction;Play;Population;Prevalence;Procedures;Protocols documentation;Provider;provider intervention;Public Health;quality assurance;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Reporting;Research;Role;Sample Size;Sampling;Self Efficacy;service delivery;service intervention;Services;Site;social communication;Source;Stress;System;Technology Assessment;Testing;Training;treatment as usual;treatment effect;Variant

PROJECT_TITLE: 1/4: Improving the Part C Early Intervention Service Delivery System for Children with ASD: A Randomized Clinical Trial


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE: Glaucoma is a leading cause of incurable vision loss, and increased pressure inside the eye is a major risk factor. There is strong evidence that the biomechanical properties of the eye contribute to the well-known interindividual differences in susceptibility to increases in eye pressure. The proposed research will uniquely define protective biomechanical properties which may serve as new and more effective therapeutic targets.

PI_NAMEs: PARK, SHIN AE  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: 3D ultrasound;Age;Animals;Astrocytes;Atomic Force Microscopy;Autopsy;Axon;Behavior;Biomechanics;Blindness;Cadaver;Canis familiaris;Cell Death;Cell Physiology;Cells;Chronic;Clinical;Clinical Data;clinically relevant;Collagen;Data;Development;disease model;Disease Progression;Elastin;Electroretinography;Exhibits;Extracellular Matrix;Eye;Fibroblasts;Genes;Genetic;genetic approach;Glaucoma;Goals;Histologic;Histology;Human;improved;in vivo;Individual;Individual Differences;Induced Mutation;innovation;Ligation;limbal;Maps;Matrix Metalloproteinases;Measures;Mechanics;Medical;Mentors;Microfibrils;Missense Mutation;Modeling;Molecular Genetics;multidisciplinary;mutant;Mutation;nerve damage;Neuroglia;neuroprotection;new therapeutic target;Normal Cell;novel;novel therapeutic intervention;novel therapeutics;Open-Angle Glaucoma;Operative Surgical Procedures;Optic Disk;Optic Nerve;optic nerve disorder;Optical Coherence Tomography;Papillary;Pathogenicity;Patients;Persons;Physiologic Intraocular Pressure;Predisposition;preservation;pressure;Property;Publishing;Research;Resistance;Retinal Ganglion Cells;Risk Factors;Role;Sclera;Structure;Testing;therapeutic target;therapeutically effective;Tissues;Trabecular meshwork structure;Translational Research;translational study;Vision;Vision Tests

PROJECT_TITLE: Biomechanical and genetic effects on glaucoma progression


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: Project Narrative Animals and plants are composed of somatic cells that form the body, and germ cells that transmit genetic material to the next generation via the union of egg and sperm. This international conference will cover the latest research in germline biology in a range of organisms and experimental systems. By focusing on emerging topics in germline specification, the development of germ cells, gamete formation, fertilization and egg to embryo transition, the meeting will provide unique opportunities for sharing results and for fostering collaborations. The knowledge presented should positively impact the study of gene transmission and reproduction as relevant for human health and breeding of animals and plants.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Agriculture;animal breeding;Animals;Area;Basic Science;Biochemistry;Biological Models;Biology;career;career development;career networking;Cell Differentiation process;Cell Lineage;Cells;Cellular biology;Collaborations;Data;Development;egg;Embryo;Embryonic Development;Ensure;Environment;Epigenetic Process;Equilibrium;Ethics;Evolution;Faculty;Fertility;Fertilization;Fostering;Gene Expression Regulation;Genes;Genetic;Genetic Materials;Genome;Genomics;Germ Cells;Germ Lines;germline stem cells;graduate student;Health;Heritability;Human;Individual;Industry;interest;International;Interview;Knowledge;Laboratories;Lead;Malignant Neoplasms;Mediation;Medicine;meetings;Meiosis;Minority;model organism;Molecular;Molecular Biology;next generation;Oral;Organism;Participant;Pharmacology;Physiology;Plants;Positioning Attribute;Postdoctoral Fellow;posters;Production;programs;Published Comment;Publishing;replacement tissue;Reproduction;Research;Research Institute;Research Personnel;Schedule;Science;Scientist;Series;Somatic Cell;Source;Specific qualifier value;sperm cell;stem cell biology;structural biology;Structure of primordial sex cell;success;symposium;System;Techniques;Thinking;tissue stem cells;Touch sensation;transmission process;unpublished works;Visit;Woman;Work

PROJECT_TITLE: CSHL Conference on Germ Cells

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Genetics;Microbiome;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative The opioid crisis has resulted in an alarming number of infants with a history of prenatal opioid exposure. Opioids are known to impair immune responses, thus uncovering how prenatal opioid exposure contributes to immune dysfunction is of great interest. This proposal postulates that immune dysfunction following prenatal opioid exposure may be the result of modulation of gut microbiota and epigenetic reprogramming of intestinal macrophages.

PI_NAMEs: ABU, YAA  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Address;Adult;Affect;Age;Animal Model;Anti-Inflammatory Agents;Attenuated;Birth;Brain region;brain tissue;Cells;Chronic;Circulation;cytokine;Data;Development;differential expression;Distress;dysbiosis;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;epigenetic regulation;epigenome;Equilibrium;experience;Exposure to;fetal opioid exposure;Functional impairment;genomic locus;Goals;gut dysbiosis;gut microbes;gut microbiome;gut microbiota;gut-brain axis;Histones;Human;Hydromorphone;Immune;Immune response;Immune system;Immune System Diseases;immunoregulation;Immunosuppression;Impairment;in utero;Incidence;Infant;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;insight;interest;Interleukin-1 beta;Intestines;Investigation;Life;Lysine;Macrophage;Maintenance;Measures;Mediating;metabolome;microbial;microbiome;Modeling;Modification;Molecular;Morbidity - disease rate;Morphine;mortality;mouse model;Mus;National Institute of Drug Abuse;Neonatal;Neonatal Abstinence Syndrome;Neurologic Symptoms;neutrophil;offspring;Opioid;opioid epidemic;opioid exposure;opioid use;opioid user;Phenotype;Play;Population;postnatal;Pregnancy;prenatal;prenatal exposure;probiotic therapy;Production;promoter;Promoter Regions;Recording of previous events;Regulation;Reporting;reproductive;response;Role;Streptococcus pneumoniae;Syndrome;systemic inflammatory response;Systemic Inflammatory Response Syndrome;Taxonomy;Testing;TLR4 gene;TNF gene;United States;Woman

PROJECT_TITLE: Prenatal Opioid Exposure and Inflammation: The Role of the Microbiome and Epigenome.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07-U(20)L]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Bioengineering;Clinical Research;Data Science;Diabetes;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Activity;Prevention

ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Type 1 diabetes is difficult to manage during exercise, and few validated tools exist to recommend treatment options to avoid dangerous complications resulting from low blood glucose. This proposal combines physiological modelling and deep learning to develop a novel artificial intelligence decision support system to help multiple daily injection users maintain safe blood glucose levels during and after exercise. We will build and validate this system in three parts: 1) we will tune a decision support system to correctly identify issues in patient glycemic control and recommend appropriate treatment modifications; 2) we will develop a new hypoglycemia prediction tool that reflects the longitudinal dynamics of glucose uptake during and after exercise; and 3) we will explore the performance of this decision support system and hypoglycemia prediction tool in a clinical trial.

PI_NAMEs: YOUNG, GAVIN  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acute;Address;Adult;Aerobic;Aerobic Exercise;Affect;Algorithms;Area;Artificial Intelligence;artificial intelligence model;Behavior;Big Data;Blood Glucose;Carbohydrates;Clinic;Clinical Medicine;Clinical Trials;Compensation;Complex;computer framework;Consensus;Continuous Glucose Monitor;Control Groups;Cutaneous;Dangerousness;Data;Data Set;Decision Support Systems;deep learning;design;Diabetes Mellitus;diabetic;Disease;Dose;Eating;empowerment;Event;Exercise;exercise regimen;experience;experimental study;Fright;Functional disorder;Future;Glucose;glucose uptake;glycemic control;Goals;Guidelines;Hour;Human;human model;human study;Hybrids;Hypoglycemia;improved;in silico;Injections;Insulin;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Intake;Jogging;mathematical model;Mathematics;Mediating;medical complication;model building;Modeling;Modification;next generation;novel;Outcome;Participant;Patients;Performance;Persons;Physical activity;Physical Exercise;physiologic model;Physiological;Physiology;predictive modeling;predictive tools;primary outcome;Production;Recommendation;Recording of previous events;recruit;Research;Resistance;resistance exercise;response;Running;Safety;safety assessment;secondary outcome;simulation;smartphone application;strength training;Structure of beta Cell of islet;Support System;support tools;Surveys;System;Techniques;Time;tool;Tracer;Training;United States;usability;Variant;Walking;Weight Lifting;Work

PROJECT_TITLE: Leveraging Big Data and Deep Learning to Develop Next Generation Decision Support Tools to Improve Glycemic Outcomes in Type 1 Diabetes


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Neurosciences;Rehabilitation;Stroke

ORG_CITY: BOSTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative  Stroke is a leading cause of long-term disability among American adults, and so promoting recovery from devastating stroke conditions such as aphasia (an acquired language disorder) is a public health priority. Aphasia recovery is often greatest in the first few months after stroke (the subacute phase), yet recovery extent varies widely between stroke survivors and cannot currently be predicted for individual patients. This research aims to address this problem by identifying currently unknown relationships between subacute phase brain function patterns and language recovery in people with aphasia.

PI_NAMEs: MEIER, ERIN LYNN (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Acquired Language Disorders;acute stroke;Address;Adult;Affect;American;Aphasia;aphasia recovery;Area;Behavior;behavior change;Brain;brain behavior;Chronic;Chronic Phase;chronic stroke;Cognitive deficits;cognitive skill;Communication difficulty;comparison control;cost;Data;data integrity;design;Disease;dorsal visual stream;early onset;Exhibits;experience;flexibility;Foundations;Functional Imaging;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Home;Image;imaging study;Impairment;improved;indexing;Individual;individual patient;Injury;insight;inter-individual variation;Knowledge;Language;Language Disorders;language impairment;language outcome;Language Tests;Left;Lesion;Linguistics;Long term disability;Magnetic Resonance Imaging;Measures;Modality;Modeling;Modernization;MRI Scans;multimodality;Nature;neural;Neurobiology;Neuronal Plasticity;noninvasive brain stimulation;novel;Participant;Patients;Pattern;Persons;Phase;Phenotype;phonology;portability;post stroke;predictive modeling;Process;Prognosis;Protocols documentation;public health priorities;Quality of life;Recovery;Research;Residual state;Rest;Sampling;Semantics;Site;skills;social situation;source localization;Stroke;stroke recovery;stroke survivor;stroke-induced aphasia;Structure;System;Testing;Time;Time Study;trait;ventral visual stream;wearable device;Work

PROJECT_TITLE: Functional Connectivity Correlates of Subacute to Early Chronic Post-Stroke Aphasia Recovery

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Principal Investigator (Last, First, Middle): Anton, Eva S. Project Narrative The emergence of progenitor diversity and the resultant neuronal organization and connectivity lay the foundation for an appropriately wired cerebral cortex. We plan to deconstruct the molecular logic of progenitor diversity and neuronal connectivity necessary for the formation of the cerebral cortex using models of neurodevelopmental disorders. Consequently, this work will provide a framework to establish how changes in progenitor balance or neuronal connectivity can lead to neurodevelopmental disorders and brain malformations.

PI_NAMEs: ANTON, EVA S (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: autism spectrum disorder;brain malformation;Cerebral cortex;Cilia;Cortical Malformation;Development;Developmental Process;Diagnostic;Epilepsy;Equilibrium;Evaluation;Foundations;Generations;genetic manipulation;Genetic Models;Goals;Growth;Human;Image;innovation;insight;lissencephaly;Logic;Macrocephaly;Maintenance;Maps;Mediating;Microcephaly;Modeling;Molecular;mouse genetics;Mutation;Neurodevelopmental Disorder;neuronal circuitry;neuronal growth;Neurons;optogenetics;Population;Principal Investigator;Production;progenitor;Proliferating;Radial;Schizophrenia;Services;Signal Transduction;single cell genomics;Therapeutic;Time;Work

PROJECT_TITLE: DEFINING MECHANISMS OF PROGENITOR BALANCE AND NEURONAL CONNECTIVITY


NIH_SPENDING_CATS: Aging;Clinical Research;Estrogen;Infectious Diseases;Microbiome;Urologic Diseases;Women's Health Research

ORG_CITY: RICHARDSON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: Project Narrative Postmenopausal women are disproportionately affected by recurrent urinary tract infection (rUTI), a disease that can persist for years and greatly lower quality of life. High rates of antimicrobial resistance and allergy have rendered many front-line antibiotics ineffective against rUTI and new therapies are urgently needed. The recently characterized microbiome of the urinary tract has been identified as a promising source of new rUTI therapies; therefore, the goal of this project is to gain the foundational knowledge necessary for the rational design of effective probiotic therapies for rUTI, using state-of-the-art techniques and human cohorts to determine the function of the urinary microbiome and how it, along with the chemical environment of urine, are altered during rUTI in postmenopausal women.

PI_NAMEs: DE NISCO, NICOLE JANELL (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: 3-Dimensional;Address;Affect;Anatomy;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;Bacteria;Bacterial Infections;biobank;Bladder;Carbohydrates;Carbon;Chemicals;Classification;cohort;combat;community-acquired UTI;Data;Development;Disease;Disease remission;Disproportionately impacts women;dosage;Environment;Estrogen Therapy;Estrogens;Excretory function;Genetic;Goals;Health;healthcare burden;Hormonal Change;Human;Hypersensitivity;Incidence;Infection;infection management;Knowledge;Lactobacillus;longitudinal analysis;Longitudinal Studies;Maintenance;Mass Spectrum Analysis;Measures;member;Metabolic;Metabolism;metagenome;metagenomic sequencing;Methods;microbiome;microbiome analysis;microbiota;Modality;Modeling;multidisciplinary;novel therapeutics;Oral;Outcome;Pathway interactions;Patients;Persons;Population;Postmenopause;Predisposition;Premenopause;probiotic therapy;Quality of life;rational design;Recording of previous events;Recovery;Recurrence;Refractory;Relapse;Role;Sampling;Shotguns;Source;spatiotemporal;Structure;targeted treatment;Techniques;Testing;Time;Urethra;urethral microbiome;urinary;Urinary Microbiome;Urinary tract infection;Urine;Urologic Diseases;Uropathogen;Vagina;vaginal microbiome;vaginal microbiota;Woman;Work

PROJECT_TITLE: Defining the dynamics of urobiome structure and function in postmenopausal women and its role in recurrent UTI susceptibility

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Aging;Nutrition;Obesity;Prevention

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE  People over age 65 typically suffer from visceral adiposity, which accelerates aging by promoting insulin resistance, cardiovascular dysfunction, and many other chronic health conditions, significantly shortening healthspan and lifespan. We recently discovered that the generation of new fat cells is the major contributor of age-associated adiposity, and we propose to study when, where, and why does the making of new fat cells take place during aging. Successful completion of the proposed research will provide new therapeutic avenues for the prevention and treatment of age-associated adiposity and its related chronic diseases, ultimately promoting longevity and healthy aging.

PI_NAMEs: WANG, QIONG ANNABEL (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Abdomen;adipocyte differentiation;Adipocytes;Adipose tissue;adult stem cell;Age;age acceleration;Age Months;age related;aged;Aging;aging related;American;Area;Biological Assay;Cardiovascular system;Cell Aging;Cell Enlargement;Cell Physiology;cell type;Cells;Censuses;Chronic;Chronic Disease;Circulation;Data;Diet;differentiation in vitro;Exhibits;experimental study;Functional disorder;Generations;Goals;Grant;Health;healthspan;healthy aging;Human;human old age (65+);Hypertrophy;In Vitro;in vivo;Inflammatory;insight;Insulin Resistance;Knowledge;life span;lipid biosynthesis;Location;Longevity;mouse model;Mus;novel;novel therapeutics;Obesity;old mice;paracrine;Persons;Play;Population;prevent;Prevention;pro-aging;Process;Proliferating;Research;Role;Sampling;senescence;senescent cell;single cell sequencing;Stains;Study models;subcutaneous;Testing;Time;Tissue Expansion;Transplantation;Visceral

PROJECT_TITLE: Defining the Role of Adipogenesis in Age-Associated Adiposity

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Our analysis of the emergence of heterochromatin will advance understanding of epigenetic programming, disruptions of which contribute to cancer and developmental abnormalities. Our studies of mitochondrial genetics probe mechanisms of inheritance of mitochondrial diseases and degenerative changes with aging. These mitochondrial studies might uncover targets for interventions that would block propagation or accumulation of pathogenic mitochondrial mutations.

PI_NAMEs: O'FARRELL, PATRICK H (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: age related;age related decline;Aging;Behavior;Binding;Biology;Cell Cycle;Cells;Chromatin Modeling;Chromatin Structure;Collaborations;Complex;Development;disease transmission;Dissociation;Drosophila genus;Embryo;Epigenetic Process;Evolution;experimental study;Genetic;genetic element;Genome;genome integrity;Genomics;Heterochromatin;heterochromatin-specific nonhistone chromosomal protein HP-1;histone methylation;In Vitro;in vivo;inhibitor;Intervention;Learning;Liquid substance;Malignant Neoplasms;Mitochondria;Mitochondrial Diseases;mitochondrial genome;Mitochondrial Inheritance;Molecular;mutant;Mutation;Nuclear;Nucleosomes;Outcome;Pathogenicity;Phase;Phenotype;Positioning Attribute;programs;recruit;Repetitive Sequence;Schedule;Severity of illness;Specific qualifier value;Supervision;Therapeutic;Time;tool;transmission process

PROJECT_TITLE: Embryonic Emergence of Heterochromatin and Nuclear Supervision of Mitochondrial Genetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Interstitial Cystitis;Neurosciences;Prevention;Radiation Oncology;Urologic Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE Radiation cystitis is a debilitating condition caused by pelvic tumor irradiation that is associated with inflammation, neurogenic detrusor overactivity, hemorrhagic cystitis and chronic fibrosis that may require a cystectomy and where current therapies, which are often ineffective, focusing only on controlling hemorrhaging. Accordingly, our goals are to better characterize the pathophysiology of radiation cystitis in order to implement novel agents, to be used singly or in combination, to enhance its treatment: 1) mitochondrially targeted free radical scavenger, XJB-5-131; 2) p75 neurotrophin receptor (p75NTR) modulator, LM11A-31; 3) soluble guanylyl cyclase (sGC) activator, cinaciguat; and 4) intravesical infrared dye or contrast media mixture, gadobutrol/ferumoxytol, to selectively irradiate the bladder within the abdomen, or enhance non-invasive magnetic resonance imaging (MRI) of bladder wall fibrosis, respectively. As LM11A-31 and cinaciguat have passed clinical safety trials for non-urological pathologies, the proposal has considerable clinical relevance.

PI_NAMEs: KANAI, ANTHONY JOHN (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Abdomen;Acute;afferent nerve;American Cancer Society;Antioxidants;Apoptosis;awake;Biopsy;Bladder;cancer diagnosis;Cancer Patient;Cells;Cessation of life;Chronic;Chronic Phase;Clinical;clinically relevant;Collagen;conditional knockout;Contrast Media;Cystectomy;Cystitis;cytochrome b5 reductase;Data;Decerebration procedure;Deposition;design;Diagnosis;Dose;Dyes;Electrocoagulation;ferumoxytol;Fibrosis;Fluorescent Dyes;Formalin;Free Radical Scavengers;Functional disorder;gadobutrol;Goals;Hemorrhage;Histologic;Human;Hyperbaric Oxygen;imaging modality;Impairment;In Situ;Individual;Inflammation;Inflammatory;Inner mitochondrial membrane;intravesical;irradiation;Knockout Mice;Legal patent;Magnetic Resonance Imaging;Malignant Neoplasms;men;Mitochondria;mitochondrial dysfunction;Molecular;Monitor;mouse model;Mus;Myofibroblast;NADP;Nerve;Nerve Degeneration;NGFR Protein;non-invasive imaging;non-invasive monitor;novel;novel therapeutics;Organ;Outcome;Pathology;Pelvic Cancer;Pelvis;Phase;Physiological;Pre-Clinical Model;prevent;Prevention;radiation cystitis;Radiation therapy;Reactive Oxygen Species;Receptor Signaling;Reporter;Rodent;Safety;Signal Transduction;Smooth Muscle;Soluble Guanylate Cyclase;Telemetry;Testing;Therapeutic Agents;Thinness;Transforming Growth Factor beta;Treatment Protocols;tumor;United States;urologic;Urothelial Cell;Urothelium;Visualization;Woman

PROJECT_TITLE: Novel Mechanistic Approaches in Prevention, Treatment and Non-Invasive Assessment of Radiation Cystitis in Mice

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infertility;Polycystic Ovary Syndrome (PCOS);Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PCOS is a common genetic disorder affecting up to 15% of reproductive-age women worldwide. PCOS is a leading cause of infertility and type 2 diabetes in young women. Our studies promise to define biologically relevant subtypes of PCOS and to identify genes contributing to PCOS in diverse populations.

PI_NAMEs: DUNAIF, ANDREA E (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Adipocytes;Affect;African;African American;Age;anovulatory infertility;Asian ancestry;Biological Assay;Body mass index;case control;case finding;causal variant;Cell Line;Cluster Analysis;cohort;Cohort Studies;Complex;CRISPR/Cas technology;Data;Diagnosis;diagnostic criteria;Disease;disorder subtype;East Asian;Etiology;European;European ancestry;Expert Opinion;functional genomics;gene discovery;Genes;genetic architecture;genetic association;Genetic Diseases;genetic variant;genome wide association study;genome-wide;Glucose;Heritability;high body mass index;Hispanic;Human;individualized medicine;Infertility;insight;Insulin;Knowledge;Koreans;Luteinizing Hormone;Maps;Meta-Analysis;Metabolic;Metabolic Diseases;Neurosecretory Systems;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Pathogenesis;Pathway interactions;Patient Self-Report;Phenotype;Polycystic Ovary Syndrome;Population;Population Heterogeneity;Reporter;reproductive;reproductive system disorder;Research;Series;Sex Hormone-Binding Globulin;Signal Transduction;Testing;timeline;Tissues;trait;United States National Institutes of Health;Untranslated RNA;Variant;Woman;young woman

PROJECT_TITLE: Elucidating the Genetic Architecture of Metabolic and Reproductive PCOS Subtypes in Diverse Populations

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The virulence of SARS-CoV-2 and its toll on human health is staggering, and the need for a safe and effective vaccine remains dire. This proposal aims to develop and optimize a better adjuvant for a SARS-CoV-2 vaccine based on a proven strategy developed for influenza virus vaccination by using a combination adjuvant strategy to activate an array of innate receptor pathways which more closely recapitulates natural viral infection. We anticipate that these studies will lead to a translatable adjuvant compatible with different vaccine platforms and will accelerate and improve the protective efficacy of SARS-CoV-2 vaccines, while promoting the types of responses which avoid vaccine related enhancement of disease.

PI_NAMEs: SCHOTSAERT, MICHAEL ;WONG, PAMELA TINMOI (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: 2019-nCoV;Acceleration;adaptive immune response;adaptive immunity;Address;Adenovirus Vector;Adjuvant;aged;Agonist;Animals;Anti-viral Response;Antibodies;Antibody Avidity;Antibody Response;Antibody-Dependent Enhancement;Antigens;antiviral immunity;Automobile Driving;Cellular Immunity;Chemicals;Clinical;Coronavirus;coronavirus vaccine;COVID-19;COVID-19 patient;COVID-19 vaccine;Data;Disease;Dose;Effectiveness;Elderly;Ensure;Environment;Epitopes;Exhibits;Formulation;Future;Generations;Hamsters;Health;Human;Immune;Immune response;Immunity;immunopathology;improved;Individual;Infection;Influenza;Influenza vaccination;influenzavirus;Innate Immune Response;insight;Interferon Type I;Intramuscular;lead optimization;Ligands;Light;Longevity;Lung;medical schools;Mesocricetus auratus;Modeling;Morbidity - disease rate;mortality;mouse model;Mucosal Immunity;Mucous Membrane;Mus;Mutation;nanoemulsion;neutralizing antibody;novel;pathogen;Pathology;Pathway interactions;Patients;permissiveness;Phase;Population;Positioning Attribute;Prevalence;Prevention;protective efficacy;rational design;receptor;Respiratory syncytial virus;response;RNA;Role;Route;Safety;safety study;SARS coronavirus;SARS-CoV-2 antigen;SARS-CoV-2 immunity;SARS-CoV-2 infection;Selection Criteria;Sendai virus;senescence;Shapes;Sterility;System;T cell response;Technology;Testing;tissue resident memory T cell;tool;Transgenic Mice;Vaccination;vaccine candidate;vaccine development;vaccine efficacy;vaccine platform;Vaccines;Variant;Viral;Virulence;Virus;Virus Diseases;Work

PROJECT_TITLE: Combined adjuvant approaches for enhancement of SARS-CoV-2 vaccine efficacy

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: GENETICS

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative Astrocytes are the most abundant cell type in the mammalian nervous system and actively contribute to neural circuit formation by influencing the neurons around them. The precise timing by which neural stem cells transition from generating neurons to astrocytes is an important variable in the formation of proper neural circuits and has been implicated in various neurodevelopmental disorders. This proposal uses genomic and stem cell-based approaches to identify the cellular origins of human astrocytes and the molecular pathways that drive gliogenesis. Together, this knowledge will help reveal new avenues for studying the pathogenesis and therapeutic strategies of neurodevelopmental disorders.

PI_NAMEs: SLOAN, STEVEN A (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: 3-Dimensional;Acceleration;activating transcription factor;Address;Appearance;Area;Astrocytes;ATAC-seq;Automobile Driving;axonal pathfinding;Bar Codes;Binding;bioinformatics pipeline;Biological Models;Categories;Cell division;Cell Fate Control;cell type;Cells;Central Nervous System;Chromatin Remodeling Factor;Competence;Data;Development;Drosophila genus;Enhancers;epigenomics;Exhibits;experimental study;flexibility;fly;Gene Expression;Gene Expression Regulation;Generations;Genes;genetic manipulation;Genetic Transcription;Genome;Genomics;gliogenesis;Human;Human Development;human induced pluripotent stem cells;human stem cells;Impairment;Individual;innovation;Intrinsic drive;knock-down;Knowledge;migration;Molecular;Molecular Evolution;Molecular Profiling;Morphology;mosaic;Mosaicism;nerve stem cell;Nervous System;nervous system development;neural circuit;Neurodevelopmental Disorder;neurogenesis;Neuroglia;Neurons;novel;Organoids;Pathogenesis;Pathway interactions;Pattern;Phenotype;Physiological;Physiology;Population;Primates;Process;progenitor;programs;promoter;prospective;Protocols documentation;Radial;recruit;Repression;Reproducibility;Rodent;Route;Scheme;Signal Transduction;Site;small hairpin RNA;Specific qualifier value;stem cell based approach;stem cell population;stem cells;Surface;synaptogenesis;System;Testing;Therapeutic;Time;tool;trait;transcription factor;Ventricular;Work

PROJECT_TITLE: Molecular Drivers of Human Gliogenesis

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: HL

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: The mitochondrial ATP synthase is a multi-subunit complex that generates most ATP in mammalian cells and has also been suggested to function as the mitochondrial permeability transition pore. Using two independent mouse models that we engineered to be deficient in the ATP synthase complex in cardiomyocytes, we investigate these functions in isolated cardiac mitochondria, cardiomyocytes, and hearts in vivo. Loss of the mitochondrial ATP synthase in cardiomyocytes results in lethal heart failure which is mediated by novel mechanisms that we define. Additionally, our data do not support a role for the mitochondrial ATP synthase as the mitochondrial permeability transition pore and suggest that it functions as a negative regulator. Finally, we explore the role of deficient ATP synthase function in human heart failure.

PI_NAMEs: KITSIS, RICHARD N (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Adenine Nucleotide Translocase;Age;Apoptosis;ATP Synthesis Pathway;Attenuated;Biology;Cardiac;Cardiac Myocytes;Cell Death;Cessation of life;Collaborations;Complex;Cytoplasm;Data;defined contribution;Depressed mood;Disease;Electron Transport;Engineering;Event;Exhibits;experimental study;Functional disorder;gain of function;Gene Deletion;Genetic;Heart;Heart failure;heart function;Human;in vivo;Individual;Infarction;inhibitor;Investigation;Knockout Mice;Left;loss of function;Mammalian Cell;Mediating;Metabolic;Mitochondria;mitochondrial permeability transition pore;Mitochondrial Proton-Translocating ATPases;Modeling;mortality;mouse model;Mus;Myocardial dysfunction;Myocardial Ischemia;Necrosis;novel;Pathway interactions;Patients;Pharmaceutical Preparations;pressure;Protein Complex Subunit;Radioisotopes;Regulation;Reperfusion Therapy;response;Role;Specimen;Surgeon;Testing;Uncertainty;Ventricular;Wild Type Mouse

PROJECT_TITLE: Mitochondrial ATP Synthase in Cardiac Biology and Disease

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Contraception/Reproduction;Endometriosis;Genetics;Human Genome;Infertility;Pain Research;Prevention;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

PHR: PROJECT NARRATIVE: Endometriosis is a debilitating disease involving the growth of uterine tissue outside the uterus. The over-arching goals of this study are to develop a blood test for the non-invasive detection of endometriosis. The proposed study will improve our understanding of the biology of endometriosis and lead to the development of new diagnostic/screening tools to help us identify women at high risk of endometriosis for whom an intervention may be tested and for whom intervention is most critically needed.

PI_NAMEs: PETERS, DAVID GERARD (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Affect;Age;Anatomy;Area;Biology;Biopsy;Blood Tests;cell free DNA;cell type;Chronic Disease;chronic pelvic pain;Clear Cell;common symptom;Complex;cost;cost effective;Data;Detection;Development;Diagnosis;Diagnostic;Disease;disease diagnosis;disease phenotype;DNA;DNA Methylation;DNA methylation profiling;Dysmenorrhea;Dyspareunia;Early Diagnosis;economic impact;effective therapy;Endometrial;endometriosis;Endometrium;epigenomics;experience;extracellular;Foundations;Genetic;genome-wide;genome-wide analysis;Germ-Line Mutation;Gland;Goals;Growth;Gynecologic;Health;High Risk Woman;Hospitalization;Hysterectomy;improved;Infertility;Intervention;Intestines;Laparoscopic Surgical Procedures;Laparoscopy;liquid biopsy;Liquid substance;Location;Malignant neoplasm of ovary;Menarche;Menopause;Menstruation;method development;Methods;Nature;Non-Invasive Detection;novel;novel diagnostics;novel therapeutics;Oncology;Onset of illness;Operative Surgical Procedures;Pain;Pathologic;Patients;Pelvic Pain;Personal Satisfaction;Phenotype;Plasma;Postmenopause;psychologic;Quality of life;reproductive;Risk;Sampling;screening;Screening procedure;Serous;sex;social;Somatic Mutation;Symptoms;Testing;Time;Tissue Sample;Tissues;tool;urinary;Uterus;Woman;young woman

PROJECT_TITLE: The non-invasive early detection of endometriosis

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cardiovascular;Emerging Infectious Diseases;Heart Disease;Infectious Diseases;Influenza;Lung;Physical Injury - Accidents and Adverse Effects;Pneumonia and Influenza

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Our world is continually facing the challenge of influenza and other aggressive viral infections in epidemic proportions on a yearly basis. This project will examine the biology of MG53, a tissue repair gene, in cardiopulmonary protection associated with viral infection. Our findings with the dual function of MG53 in tissue repair and anti-inflammation shall provide novel means to mitigate virus-induced multi-organ injuries.

PI_NAMEs: CAI, CHUANXI ;MA, JIANJIE  (contact);YOUNT, JACOB

PROJECT_TERMS: Animal Model;Anti-Inflammatory Agents;anti-influenza drug;Anti-viral Agents;Biology;Cardiac;Cardiopulmonary;cardiopulmonary system;Cell membrane;Cells;Cessation of life;combat;Combined Modality Therapy;Custom;cytokine release syndrome;Data;Dose;Epidemic;Exposure to;Face;FDA approved;Functional disorder;gain of function;gene repair;Genes;Genetic;Goals;Heart;heart function;heart preservation;Host Defense Mechanism;Human;Immunity;Infection;infectious disease treatment;Inflammation;Influenza;influenza infection;influenzavirus;Injury;Integral Membrane Protein;Interferon Type I;Interferons;Interleukin-6;intravenous administration;Knock-out;Knockout Mice;loss of function;Lung;lung injury;Macrophage;Manuscripts;member;Membrane;Membrane Fusion;Molecular;Morbidity - disease rate;mortality;mouse model;multiorgan injury;Multiple Organ Failure;Mus;Muscle;Myocardial dysfunction;Myocarditis;novel;organ injury;overexpression;Pathology;Physiological;Play;Population;Predisposition;prevent;Production;prophylactic;Protein Family;Proteins;Publishing;pulmonary function;Pulmonary Pathology;Recombinants;repaired;Research;respiratory infection virus;Rodent;Role;Safety;Saline;seasonal influenza;Signal Transduction;Site;Study models;Testing;Therapeutic;tissue injury;tissue repair;Tissues;TRIM Gene;Viral;Virus;Virus Diseases;Wild Type Mouse

PROJECT_TITLE: Protein therapy to treat virus induced cardiopulmonary injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: HADLEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative Circadian clocks are time-tracking systems that allow organisms to adapt to the time of day, and drive many cellular functions; their alteration can lead to a variety of diseases and physiological conditions. We propose the development of a chemical biology toolkit that will enable the concurrent tracking of multiple circadian signals at different levels, and utilize chemical entities to selectively target and alter the behavior of core clock proteins. These platforms will facilitate an array of further studies to understand the roles and functioning of the molecular clock that are currently not feasible.

PI_NAMEs: FARKAS, MICHELLE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;Behavior;Binding;Binding Proteins;Biology;Cell Physiology;Cells;Chemicals;circadian;circadian pacemaker;Circadian Rhythms;Clock protein;Compensation;Development;Disease;Disparity;Feedback;Firefly Luciferases;Genes;genetic approach;Genetic Transcription;Heart Diseases;Image;Individual;knock-down;Knock-out;Malignant Neoplasms;Metabolic Diseases;Modeling;Molecular;molecular clock;mouse model;nano;nanobodies;New Agents;new therapeutic target;Organism;paralogous gene;Physiological;prevent;promoter;Proteins;Reporter;response;Role;scaffold;Signal Transduction;small molecule;Stimulus;Surface;System;Time;tool;Translations;Work;Yeasts

PROJECT_TITLE: Chemical Biology Approaches for Studying Circadian Rhythms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Chronic Pain;Clinical Research;Health Services;Neurosciences;Pain Research;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE: Chronic musculoskeletal conditions, such as low back pain, have substantial costs and burden on society. A better understanding of the underlying reason for developing chronic low back pain is needed. This award will allow the PI to expand his mentoring of trainees in musculoskeletal pain phenotypes and leverage the rich clinical research environment at Duke University to advance his current clinic research.

PI_NAMEs: GOODE, ADAM  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acute;Address;Affect;Area;Award;Biochemical;Biological;Biological Markers;Biomechanics;career;career development;Career Mobility;Cartilage;Chronic;Chronic low back pain;chronic musculoskeletal pain;chronic pain;chronic painful condition;Clinic;Clinical;clinical care;clinical implementation;clinical pain;clinical phenotype;Clinical Research;Clinical Sciences;clinically significant;Collaborations;collaboratory;Communities;Complement;cost;Data;Data Science;design;Development;Direct Costs;Discipline;Disease;Educational process of instructing;Electronic Health Record;Ensure;Environment;Epidemiology;experience;Facilities and Administrative Costs;Fostering;Funding;Generations;Goals;Health;health care service utilization;Health system;Healthcare;Healthcare Systems;Heterogeneity;High Prevalence;Image;innovation;Intervertebral disc structure;Knee Osteoarthritis;Learning;Low Back Pain;Mechanics;medical schools;meniscus injury;Mentors;Mentorship;Methodology;Methods;mid-career faculty;Midcareer Investigator Award in Patient-Oriented Research;multidisciplinary;Musculoskeletal;Musculoskeletal Pain;next generation;Occupational Therapy;opioid epidemic;Orthopedic Surgery;Outcome;Pain;pain chronification;Pain management;Pain Research;patient oriented research;Patients;Persons;Phenotype;Physical therapy;Physicians;population health;pragmatic trial;predictive marker;Prevalence;prevent;Process;Productivity;programs;psychologic;Quality of life;rehabilitation research;Request for Applications;Research;Research Design;Research Infrastructure;Research Institute;Research Methodology;Research Personnel;Research Project Grants;Resources;Risk Reduction;Role;Scientist;Serum;skill acquisition;skills;Societies;Sociology;Strategic Planning;systems research;Time;tool;Training;Training Programs;Translational Research;trial design;United States;United States National Institutes of Health;Universities;Urine;Vertebral column;Wages;Work;years lived with disability

PROJECT_TITLE: Mentoring in Musculoskeletal Pain Phenotypes

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Sepsis

ORG_DEPT: EMERGENCY MEDICINE

PHR: PROJECT NARRATIVE: Catheters we place in patients for life-sustaining therapies such as dialysis can become infected causing significant medical and economic harm. Current management of these infections frequently includes removal and replacement of the catheter which can be difficult due to their life-sustaining function and risks associated with the procedure. In this study, we will develop a strategy to treat these infections in place using a combination of heat, antibiotics, and fluid flow and thus obviate the need for risky catheter replacement procedures.

PI_NAMEs: VANEPPS, J SCOTT (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Adjuvant;Adopted;Animals;Antibiotics;antimicrobial;Bacteria;Biomass;Blood Vessels;Caring;Catheters;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;clinical practice;Clinical Trials;comorbidity;Complication;cost;Coupled;Data;Device Removal;Devices;Dialysis procedure;Disease;Dose;Economics;End stage renal failure;Excision;experimental study;fluid flow;Functional disorder;Future;Geometry;Goals;healthcare-associated infections;heat injury;Hemodialysis;high risk;Human;Immune response;improved;In Situ;Incidence;Infection;infection management;instrumentation;Life;life-sustaining therapy;Liquid substance;Mechanics;Medical;Medical Errors;Microbial Biofilms;Modeling;Morbidity - disease rate;mortality;Nature;Patients;Phase;Population;Preparation;Procedures;Publishing;Rattus;Recommendation;Regimen;Reporting;research clinical testing;Risk;Role;Sepsis;Specific qualifier value;Standardization;Surface;System;Temperature;Therapeutic heat application;therapy development;therapy duration;Time;Translating;Translations;treatment optimization;treatment strategy;trend;Uncertainty;Vancomycin;Venous;Work

PROJECT_TITLE: Adjuvant heat treatment for catheter salvage in central line associated bloodstream infection (HEATSAVE)

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Aging;Biotechnology;Rare Diseases

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: PROPOSAL NARRATIVE SS peptides are among the most promising therapeutic compounds for the treatment of mitochondrial dysfunction associated with primary heritable diseases, chronic pathologies, and aging-related declines in health. Understanding the mode of action of these compounds coupled with the identification of variants with greater activity will mark a significant advance in the quest to treat mitochondrial disorders. The objective of the proposed research plan is to elucidate the molecular mechanism by which SS peptides operate at the membrane, mitochondria, and cellular levels, particularly with respect to aging-related diseases, and to evaluate a library of SS peptide variants that will inform the design of next-generation compounds with greater bioavailability and efficacy.

PI_NAMEs: ALDER, NATHAN N (contact)

PROJECT_TERMS: Affect;Aging;aging related;aging related disease;Alzheimer's Disease;Animal Diseases;Behavior;Binding;Bioenergetics;Biological Assay;Biological Availability;Biomimetics;biophysical analysis;biophysical techniques;Biophysics;Calcium;Calorimetry;Cardiolipins;Cell Culture Techniques;Cell Line;Cell model;Cell Physiology;Cell Survival;Chronic;Clinical Trials;Complex;Confocal Microscopy;Coupled;Crista ampullaris;crosslink;design;Diabetes Mellitus;Disease;Electrostatics;Energy Metabolism;Equilibrium;Evaluation;FDA approved;Fluorescence;Foundations;Free Radical Scavenging;functional restoration;Gene Expression;Goals;Health;Heart Diseases;Heritability;improved;Inner mitochondrial membrane;insight;interdisciplinary approach;Interdisciplinary Study;interfacial;Ions;islet amyloid polypeptide;Kidney Diseases;Kinetics;Label;Lead;Libraries;Lipid Bilayers;lipidomics;Lipids;Lipoproteins;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Medicine;Membrane;membrane assembly;membrane model;Membrane Structure and Function;Metabolic Diseases;Mitochondria;Mitochondrial Diseases;mitochondrial dysfunction;mitochondrial membrane;Modeling;Molecular;Molecular Analysis;Molecular Conformation;molecular dynamics;Molecular Mechanisms of Action;Morphology;nanodisk;Nerve Degeneration;next generation;Non-Insulin-Dependent Diabetes Mellitus;Organelles;Outcome;Oxidative Phosphorylation;Oxidative Stress;Pathologic;Pathology;Pattern;peptide analog;Peptide Conformation;peptide drug;Peptides;Permeability;Phase;physical property;Physiologic pulse;Play;Polymers;preclinical trial;preservation;Process;Production;Property;protein complex;protein expression;protein transport;Proteins;rational design;Reactive Oxygen Species;Research;Research Support;Resolution;Role;Safety;Sampling;Series;Shotguns;Side;Site;Solid;Stress;stressor;Structure;Surface;System;Techniques;Testing;Therapeutic;Thermodynamics;Treatment Efficacy;Variant;virtual;Work;Yeasts

PROJECT_TITLE: First-in-class peptide therapeutics for mitochondrial disorders: molecular mechanism of action and optimization of design


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

PHR: PROJECT NARRATIVE The rheumatologic diseases are a diverse group of conditions that together result in a large burden of disease in the United States and can lead to considerable morbidity, disability, lost work and premature death. The causes of these diseases remain poorly understood and there is a need for better therapies. This application will support the UCSF rheumatology research training of physician-scientists that for over 40 years has trained a cadre of the nation's leading researchers to address pressing questions that advance our understanding and treatment of rheumatic diseases.

PI_NAMEs: YAZDANY, JINOOS ;ZIKHERMAN, JULIE  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Clinical Immunology;Rheumatology

PROJECT_TITLE: Academic Rheumatology and Clinical Immunology


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: Los Angeles

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative This project aims to develop tools to promote genetic research of aging, behavioral, and social phenotypes in diverse populations. Existing comparable tools require that researchers omit some data when those data come from diverse populations, whereas our proposed tools account for population differences in a way that allows researchers to use much more data in more diverse samples. Using these tools, we will be able to make scientific discoveries that are more representative of the global population, which will reduce the potential for unequal benefits from genetic research.

PI_NAMEs: TURLEY, PATRICK ANSEL (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Address;African;Aging;Algorithms;Alzheimer's Disease;American;Behavioral;behavioral phenotyping;biobank;Characteristics;China;cohort;Communication;Computer software;computer studies;computerized tools;cost;Data;Data Set;Dedications;design;Dimensions;Distant;diverse data;Documentation;East Asian;Education;Environment;ethical, legal, and social implication;Ethics;European;European ancestry;experience;General Population;Genes;Genetic;genetic association;Genetic Research;Genetic study;genome wide association study;genome-wide;Genomics;Genotype;Grant;Health;Human Resources;improved;indexing;Individual;Knowledge;Linkage Disequilibrium;Methods;Modeling;novel strategies;online repository;Outcome;Paper;Performance;Persons;Phenotype;Population;Population Genetics;Population Heterogeneity;prevent;Publications;Publishing;repository;Research;Research Personnel;Sample Size;Sampling;Siblings;simulation;social;Social Sciences;Source;South Asian;Statistical Bias;statistics;tool;trait;Weight;Writing

PROJECT_TITLE: Studying the Genetics of Aging, Behavioral, and Social Phenotypes in Diverse Populations

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Newark

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Modified Public Health Relevance Section   The prevalence of schizophrenia and other mental disorders is high, and they cause severe socioeconomic stress on patients, families, and the society. Despite the identification of many genetic factors in human genetics studies, effective therapeutics are limited due to a lack of understanding of the pathophysiology of mental disorders. This proposal aims at understanding the function of SETD1A, which has been shown to be strongly associated with schizophrenia, and results derived from this study potentially will potentially help in devising novel therapeutics for mental disorders.

PI_NAMEs: MING, GUO-LI ;PANG, ZHIPING P. (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Axon;Brain;Cell Line;cell type;Cells;chromatin immunoprecipitation;Complex;CRISPR/Cas technology;Data;Defect;Development;differential expression;Electrophysiology (science);Engineering;Enhancers;Epigenetic Process;epigenomics;excitatory neuron;Exhibits;Exons;experimental study;Family;Functional disorder;functional genomics;Genes;Genetic;Genetic study;Genetic Transcription;genome wide association study;genome-wide;Goals;Heterozygote;Histone H3;histone methylation;histone methyltransferase;Human;Human Genetics;human induced pluripotent stem cells;Image;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;inhibitory neuron;Knock-out;loss of function;loss of function mutation;Loss of Heterozygosity;Lysine;Memory impairment;Mental disorders;Methylation;Modeling;Molecular;molecular phenotype;Morphology;mouse model;mutant;neural;neural model;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neuronal Differentiation;Neurons;neuropsychiatric disorder;neurotransmission;novel therapeutics;Organoids;overexpression;Pathway interactions;Patients;pharmacologic;Phenotype;Physiology;Population;premature;Prevalence;promoter;Property;public health relevance;Resolution;risk variant;Role;Schizophrenia;SET Domain;Short-Term Memory;single nucleus RNA-sequencing;Societies;socioeconomics;stem cell model;Stress;Structure;Supporting Cell;Synapses;synaptic function;System;Techniques;therapeutically effective;trait;transcriptome;transcriptome sequencing;transcriptomics;Variant

PROJECT_TITLE: Loss-of-Function Analyses of SETD1A in Human Neural Models


ADMINISTERING_IC: OD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative – Overall The Tulane National Primate Research Center (TNPRC) has a mission to improve human and animal health through basic and applied biomedical research. The Center serves as a national resource for biomedical research that requires the use of nonhuman primates. Hundreds of NIH-funded investigators each year rely on the resources of the TNPRC to conduct their research.

PI_NAMEs: HAMM, L LEE (contact)

PROGRAM_OFFICER_NAME: BUHRING, BETTINA D

PROJECT_TERMS: 2019-nCoV;Accreditation;Aging;animal care;Animal Model;animal resource;Animals;applied biomedical research;Area;aspirate;Automation;Award;base;biocontainment facility;Biomedical Research;biomedical resource;career development;Cellular Immunology;Chronic;Communities;comorbidity;Containment;Contracts;COVID-19;COVID-19 pandemic;data centers;Dedications;Development;Education;Electronics;Emerging Communicable Diseases;Employee;empowerment;energy efficiency;Engineering;Environment;equity, diversity, and inclusion;evidence base;Faculty;Funding;Generations;Grant;Growth;Health;Health Sciences;HIV/AIDS;Human;imaging facilities;improved;industry partner;Infection;Infrastructure;Institution;Investments;Laboratories;Leadership;Lighting;Louisiana;Lung;medical schools;Methods;Mission;Modeling;mouse model;Mus;National Institute of Allergy and Infectious Disease;nonhuman primate;operation;outreach;Pathogenicity;Performance;PET/CT scan;Play;Post-Acute Sequelae of SARS-CoV-2 Infection;Postdoctoral Fellow;Primates;Private Sector;programs;Public Health Schools;quality assurance;Quality Control;recruit;Request for Applications;Research;Research Personnel;Resources;response;Role;SARS-CoV-2 infection;Schools;Science;Speed;square foot;Strategic Planning;success;System;Technology;therapeutic evaluation;Therapeutic Studies;Time;Training;Training Activity;Training and Education;Tropical Medicine;Tuberculosis;undergraduate student;United States National Institutes of Health;Universities;Update;vaccine evaluation;Vaccines;Vision;Work

PROJECT_TITLE: Tulane National Primate Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-A(41)P]


ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: The goal of this MIRA grant application is to continue developing a research program aiming to understand the biogenesis of mitochondrial membranes, with a focus on (1) oxidative phosphorylation (OXPHOS) individual enzymes and supercomplexes, and (2) mitoribosomes and the mitochondrial translation machinery, as they occur in yeast and human cells. Disorders arising from impaired mitochondrial OXPHOS function or mitochondrial gene expression, including protein synthesis, result in a variety of pathologies, including encephalomyopathies and cardiomyopathies. Identifying and characterizing factors required for OXPHOS enzyme assembly, mitoribosome biogenesis and translation, and the pathways in which they act is a prerequisite towards understanding the molecular basis of these disorders.

PI_NAMEs: BARRIENTOS, ANTONI  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Affect;Aging;Applications Grants;Biochemistry;Biogenesis;Biological;Cardiomyopathies;Catalytic Domain;Cell Nucleus;Cells;Complex;complex IV;Cryoelectron Microscopy;cytochrome c oxidase;Cytoplasm;Disease;Enzymes;Gene Expression;gene-editing approach;Genes;Genetic;Goals;Health;Human;Human Cell Line;Impairment;Individual;insight;Lead;Link;Malignant Neoplasms;Membrane;Metabolic Diseases;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial membrane;Modernization;Molecular;Molecular Structure;Mutation;Myopathy;Nerve Degeneration;Nuclear;Oxidative Phosphorylation;Pathology;Pathway interactions;Process;programs;Prosthesis;Protein Biosynthesis;protein complex;Proteins;Recombinant Proteins;reconstruction;Research;Ribosomes;Role;Science;Stress;Structure;System;Translations;yeast genetics;Yeasts

PROJECT_TITLE: Mitochondrial Biogenesis in Health and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE Understanding the function in human neurons of the vast and cell-type specific repertoire of psychiatric disease genes isoforms produced by alternative splicing will provide a clearer understanding of how these genes contribute to neuropsychiatric diseases. We will catalog full-length isoforms of psychiatric disease genes in human cortical tissues and compare them with human induced pluripotent stem cell (hiPSC)-derived 3D organoids, and studying the impact of genetic variation on the alternative splicing of these psychiatric disease genes and neuronal phenotypes.

PI_NAMEs: BRENNAND, KRISTEN JENNIFER;FANG, GANG  (contact)

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Alternative Splicing;American;autism spectrum disorder;Autopsy;Bipolar Disorder;Brain;brain control;Brain Diseases;brain tissue;Catalogs;Cell Communication;Cell model;cell type;Cells;Clinical;clinical predictors;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Data;Development;Diagnostic;differential expression;Engineering;Exhibits;Exons;Experimental Designs;Failure;fetal;Genes;Genetic study;Genetic Variation;Genotype;Glutamates;Goals;Human;human induced pluripotent stem cells;Impairment;improved;Induced pluripotent stem cell derived neurons;Length;Maps;Mental disorders;mutant;neural circuit;Neurodevelopmental Disorder;Neurons;neuropsychiatric disorder;novel;novel therapeutic intervention;Organoids;overexpression;Pattern;Phenotype;Physiological;predict clinical outcome;Prosencephalon;Protein Isoforms;Quantitative Trait Loci;Research;Resolution;risk variant;RNA Splicing;Schizophrenia;schizophrenia risk;single cell sequencing;standard care;Synapses;synaptic function;targeted sequencing;Technology;Tissues;transcriptomics;Work

PROJECT_TITLE: Resolving complex alternative splicing of psychiatric disease genes using single-cell approaches

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: THIKA

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: MOUNT KENYA UNIVERSITY

PHR: NARRATIVE Tuberculosis (TB) and COVID-19 are the leading causes of mortality from infectious diseases globally. The slow rollout of COVID-19 vaccines in low- and middle-income countries means that cases of co-infection with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and latent Mycobacterium tuberculosis (Mtb) infection will continue to take place. This proposal will identify how SARS-CoV-2 impacts reactivation of latent Mycobacterium tuberculosis (Mtb) infection or immunity to Mtb antigens.

PI_NAMEs: GITAKA, JESSE  (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: 2019-nCoV;Acceleration;Antibodies;Antigens;Antimycobacterial Agents;Biological Assay;Biological Markers;Blood;Blood specimen;CD4 Positive T Lymphocytes;Classification;Clinical;co-infection;cohort;Communicable Diseases;Country;County;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 vaccine;Data;Disease;Disease Progression;Epidemiology;Epitopes;exhaustion;Flow Cytometry;follow-up;Foundations;Frequencies;Gene Expression;Gene Expression Profiling;genetic signature;Gold;Health care facility;high risk;Immune response;Immunity;Immunoglobulin G;Immunologics;Incidence;Individual;Infection;Inflammation;Inflammatory Response;Infrastructure;interest;Interferon Type I;Interferon Type II;Interferons;Kenya;latent infection;lateral flow assay;low and middle-income countries;Measures;Mediating;mortality;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;Nucleocapsid Proteins;Participant;Patients;Peptides;Peripheral Blood Mononuclear Cell;Phenotype;Play;Population;progression risk;Public Health;Pulmonary Tuberculosis;reactivation from latency;Recording of previous events;recruit;Reporting;Research;respiratory;response;Reverse Transcriptase Polymerase Chain Reaction;Risk;risk prediction;RNA;Sampling;SARS-CoV-2 exposure;SARS-CoV-2 infection;SARS-CoV-2 variant;screening;Serology;Seroprevalences;severe COVID-19;Signal Transduction;skills;systemic inflammatory response;T cell response;T memory cell;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;therapeutic target;Tube;Tuberculin Test;Tuberculosis;tuberculosis immunity;Vaccination;vaccine efficacy;Virus Diseases;Whole Blood;Work

PROJECT_TITLE: Impact of SARS-CoV-2 infection on reactivation of latent Mtb infections in a Kenyan Cohort

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: MADISON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE In this career development award we aim to use genetic and retinal imaging data to enhance our understanding of the pathways that can lead to vision loss among people with diabetic retinal diseases. Improved understanding will translate into interventions aimed at preventing blindness from diabetes.

PI_NAMEs: CHANNA, ROOMASA  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Adult;Affect;aged;Algorithmic Analysis;American;Appearance;Artificial Intelligence;biobank;Bioinformatics;Blindness;Blood Vessels;career development;Clinical;Clinical Management;clinical practice;Clinical Research;Clinical Trials;cohort;collaborative environment;Computational algorithm;Data;Data Analyses;Data Set;Development;Development Plans;diabetes management;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Disease;Disease Pathway;Environment;experience;Family;fiber cell;Fundus;Future;Ganglion Cell Layer;Genes;Genetic;Genetic Predisposition to Disease;genetic risk factor;genome wide association study;genomic data;Genomics;Goals;Hyperglycemia;illness length;Image;Image Analysis;imaging modality;improved;Institution;Intervention;K-Series Research Career Programs;Knowledge;large datasets;macular edema;Measurement;Medical center;Mentors;Mentorship;Methods;Molecular;nerve damage;Nerve Degeneration;Nerve Fibers;novel;novel therapeutics;Optical Coherence Tomography;Outcome;Participant;Pathway interactions;Patients;Persons;Phenotype;population based;Predisposition;Prevalence;prevent;Prevention;Process;Publications;racial population;Regression Analysis;Reporting;Research;Retina;Retinal Diseases;Retinal Ganglion Cells;retinal imaging;Risk Factors;Role;Sample Size;Scanning;Scientist;screening;skills;Specialist;standard of care;Techniques;Testing;Thick;Time;Training;Translating;Translational Research;Vascular Endothelial Growth Factors;Vision;Visual;Visual disability;Work

PROJECT_TITLE: Diabetic Retinopathy: Genetics and Neurodegeneration (MSN246458)


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Nutrition;Pediatric;Physical Activity;Prevention

ORG_CITY: CHARLOTTE

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

PHR: 8. Project Narrative  The SKyRoCKeT Study (Surface-Knit and Reformulate CADENCE-Kids for Translation) will recruit a sex- and age-balanced sample of 360 young people 6-20 years of age to develop an integrative, physiologically-coherent age-cadence-log(MET) surface-based model, reformulate the prior R21 CADENCE- Kids study by providing individualized, more precise, age-specific and coherent cadence-intensity thresholds, investigate additional differences by anthropometric factors, and translate cadence-intensity thresholds to over- ground walking. The SKyRoCKeT Study is an innovative critical step to provide a coherent, interpretable, objectively monitored step-based intensity metric to inform (inter)national physical activity (PA) guidelines by transforming currently vague guidelines of PA intensity into quantifiable PA recommendations that can be of widespread use, which clinicians, young people, parents, and researchers can integrate into preventive care management and action plans for personalized care. The SKyRoCKeT Study will allow for a user-friendly, interpretable metric to more accurately inform public health/behavioral interventions, assessments, analyses, school-based health and physical education curricula and programs, and public health messages for young people and their caregivers.

PI_NAMEs: BARR-ANDERSON, DAHEIA JULINA;GUNN, LAURA H (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 20 year old;Academic achievement;Adolescent and Young Adult;Adult;Advisory Committees;Age;age related;Algorithms;Behavior;Behavior Therapy;Body mass index;Calibration;cardiometabolic risk;cardiorespiratory fitness;Caregivers;Characteristics;Child;Clinical;Cognition;Communication;cost;Data;Development;Devices;Dimensions;Dose;Educational Curriculum;Energy Metabolism;evidence base;Exertion;flexibility;Funding;Guidelines;Health;Health education;Heart Rate;Height;Heterogeneity;Human;Indirect Calorimetry;Individual;innovation;inter-individual variation;Intervention;Leg;Length;Linear Models;Managed Care;Maximum Heart Rate;Measures;Metabolic;Modeling;Moderate Exercise;moderate-to-vigorous physical activity;Monitor;Obesity;older adult;Outcome;Oxygen;Oxygen Consumption;Parents;personalized care;Persons;Physical activity;Physical Education;Physiological;Physiology;Pilot Projects;Preventive care;programs;Protocols documentation;Public Health;Public Health Applications Research;Recommendation;recruit;Reporting;Research;Research Personnel;response;Risk Factors;Running;Sampling;Schools;Science;sex;Strenuous Exercise;success;Surface;Time;Training;Translating;Translations;treadmill;uptake;user-friendly;Walking;wearable device;Weight

PROJECT_TITLE: The SKyRoCKeT Study: Surface-Knit and Reformulate CADENCE-Kids for Translation.

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: ARLINGTON

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

PHR: Project Narrative Our studies of the elimination of morphologically complex cells will provide important fundamental insights on programmed cell death and clearance, which are essential facets of proper development and homeostasis. These studies are relevant to public health in several respects: our findings may help devise targeted therapies against both tumor formation and immune dysfunction as well as in understanding brain development, injury and disease.

PI_NAMEs: GHOSE, PIYA  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Animals;Apoptosis;Architecture;Autoimmune Diseases;Biological;Brain;Caenorhabditis elegans;cancer therapy;Cell Death;Cell Physiology;Cells;Cellular biology;Cessation of life;Complex;Defect;Development;developmental disease;Disease;Embryonic Development;Excision;experimental study;Genes;Genetic;genetic analysis;Genetic study;Health;Homeostasis;Immune System Diseases;in vivo;Inflammation;Injury;insight;Interphase Cell;Lead;Link;Malignant Neoplasms;Mitochondria;Modeling;Morphology;Mutation;Nerve Degeneration;Neurons;novel;programs;Public Health;Regulation;Regulator Genes;Resistance;Role;sex;targeted treatment;trafficking;tumor

PROJECT_TITLE: In Vivo Genetic Analysis of Compartmentalized Cell Elimination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Drug Abuse (NIDA only);Emergency Care;Health Services;Mental Health;Mental Illness;Neurosciences;Opioid Misuse and Addiction;Opioids;Patient Safety;Physical Injury - Accidents and Adverse Effects;Screening and Brief Intervention for Substance Misuse;Serious Mental Illness;Substance Misuse;Suicide

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Opioid overdoses and suicides continue to be major public health problems that often converge in the emergency department (ED). The proposed study aims to establish the safety of administering ketamine to individuals with opioid use disorder who are endorsing suicidal ideation in the ED, and evaluate the preliminary efficacy on opioid- and suicide-related outcomes. Results from this study will help lay the foundation for an adequately powered efficacy trial of ketamine as a treatment option in the ED to improve opioid- and suicide-related outcomes.

PI_NAMEs: CHAI, PETER R;GOLDFINE, CHARLOTTE ;SUZUKI, JOJI  (contact)

PROGRAM_OFFICER_NAME: MANDLER, RAUL N

PROJECT_TERMS: Accident and Emergency department;Acute;Acute Pain;addiction;Address;Admission activity;Adverse effects;Agitation;alcohol use disorder;Alcohols;Anesthetics;Animals;antidepressant effect;arm;Back;behavior change;Behavior Therapy;Behavioral Mechanisms;Blood Pressure;Cardiovascular system;Caring;Cocaine use disorder;comorbidity;completed suicide;COVID-19 pandemic;craving;Data;depressive symptoms;design;Diastolic blood pressure;Disease;Dose;Double-Blind Method;drug misuse;efficacy trial;Eligibility Determination;Emergency department crowding;Emergency department visit;emergency settings;Event;experience;Face;Feeling suicidal;follow-up;Foundations;Goals;Heart Rate;hemodynamics;Human;hypertensive;improved;improved outcome;Incidence;Individual;Infusion procedures;innovation;interest;Intervention;Intravenous;Ketamine;Link;medication for opioid use disorder;Mental Depression;Mental disorders;Methods;Monitor;National Institute of Drug Abuse;Opioid;opioid overdose;Opioid Receptor;opioid use;opioid use disorder;opioid withdrawal;Outcome;Outcome Assessment;Overdose;overdose death;Pain;Participant;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Placebo Control;Placebos;Prevalence;prevent;Prevention;primary outcome;Psychiatric therapeutic procedure;Psychotherapy;Public Health;Randomized;randomized placebo controlled trial;randomized trial;Relapse;Reporting;Research;Safety;safety assessment;safety outcomes;Saline;screening;screening, brief intervention, referral, and treatment;secondary outcome;Sedation procedure;Serious Adverse Event;side effect;substance misuse;Substance Use Disorder;suicidal;Suicide;Suicide attempt;Symptoms;Tachycardia;Testing;timeline;Toxicology;treatment-resistant depression;Visit

PROJECT_TITLE: Ketamine for the treatment for opioid use disorder and suicidal ideation in the emergency department

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative Glucose is a key nutrient for supporting embryo development and decidualization of the endometrium. Our preliminary data indicate that the endometrium stores two distinct glycogen pools that may be important in regulating glucose availability to the embryo and decidua. This project will use a novel Cre/Lox mouse to separately investigate the role of epithelium and decidual glycogen and determine how obesity affects endometrial glycogen metabolism.

PI_NAMEs: DEAN, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: Address;Affect;AMHR2 gene;Area;blastocyst;C-Peptide;C57BL/6 Mouse;Circadian Rhythms;Data;Decidua;Decidual Cell Reactions;Defect;Diestrus;Diet;diet-induced obesity;early pregnancy;early pregnancy loss;Embryo;Embryonic Development;Endometrial;endometrial stroma;Endometrial Stromal Cell;Endometrium;Ensure;Enzymes;Epithelium;Estradiol;fasting glucose;Fat-Restricted Diet;Fatty acid glycerol esters;Fertility;Fertilization;Global Change;Glucose;glucose metabolism;Glucose Transporter;glucose uptake;glucose-6-phosphatase;Glycogen;glycogen metabolism;Glycogen Phosphorylase;Glycolysis;Growth Factor;GYS1 gene;High Fat Diet;Hormonal;Human;human data;Hyperglycemia;Hyperinsulinism;Hypoxia;Immunohistochemistry;Impairment;implantation;In Vitro;Infertility;Insulin;Invaded;Knock-out;Lactoferrin;Length;Link;Litter Size;LoxP-flanked allele;macromolecule;maternal obesity;Metabolism;metabolomics;Modeling;Morula;mouse model;Mus;National Institute of Child Health and Human Development;natural Blastocyst Implantation;novel;Nutrient;nutrition;Obesity;Pathogenesis;Placentation;Pre-implantation Embryo Development;Pregnancy;pregnancy failure;Pregnancy loss;Pregnancy Outcome;preimplantation;Process;Proestrus;Progesterone;Regulation;Reproduction;reproductive;Research;response;Role;Serum;Site;Spain;spatiotemporal;Time;Tissues;treatment group;Uterus;Woman

PROJECT_TITLE: Deciphering the Roles of Endometrial Glycogen Reserves and the Impact of Obesity on Fertility


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Growth factors are biochemical signals that regulate diverse cellular functions including proliferation, differentia- tion, or metabolic activity. This proposal seeks to develop new reagents and methods to selectively activate or suppress the activity of these signals with spatial and temporal control by tailoring their interactions at the sur- faces of cells. Once established, the tools will enable new biological discoveries and cell-based therapies.

PI_NAMEs: GODULA, KAMIL  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Anabolism;analytical tool;Basic Science;Binding;Biochemical;Biological;Biological Assay;Biological Products;biological research;Biomedical Research;cancer therapy;Carrier Proteins;Cell Differentiation process;Cell Line;Cell membrane;Cell Physiology;Cell Proliferation;Cell surface;Cell Therapy;Cells;cellular engineering;Chemicals;Chimera organism;Communities;Complex;Data;Development;Disease;Disease Management;Elements;embryonic stem cell;Engineering;Enzymes;Equilibrium;extracellular;Family;FGF1 gene;FGF2 gene;Fibroblast Growth Factor;Fibroblast Growth Factor Receptor 1;Fibroblast Growth Factor Receptor 2;Fibroblast Growth Factor Receptors;Future;Gene Expression;Genetic Engineering;Goals;Growth Factor;Growth Factor Inhibition;Growth Factor Interaction;Growth Factor Receptors;Harvest;Heparan Sulfate Biosynthesis;Heparan Sulfate Proteoglycan;Heparitin Sulfate;Heterogeneity;Immune System Diseases;improved;inorganic phosphate;Laboratories;Ligands;Link;Lipids;Lysosomes;Macrophage;Malignant Neoplasms;man;Mediating;member;Membrane;Metabolic;Methods;mimetics;Mus;mutant;Mutation;nerve stem cell;new technology;Oligosaccharides;Outcome;Patients;Polysaccharides;polysulfated glycosaminoglycan;Production;Proliferating;Property;Protein Family;Proteoglycan;prototype;Proxy;Reagent;receptor;Recombinants;Recycling;regeneration potential;Regenerative Medicine;Regulation;Regulatory Element;response;scaffold;Scaffolding Protein;Signal Pathway;Signal Transduction;Signaling Protein;Specificity;Structure;Structure-Activity Relationship;Sulfate;System;Techniques;Technology;Therapeutic;Therapeutic Uses;Tissue Engineering;tool;Work

PROJECT_TITLE: Cell membrane-targeting proteoglycan chimeras as selective growth factor signaling actuators

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Nearly one in five children are obese, and disparities in overweight and obesity between children from low- and middle-to-high-income households persist despite a multitude of school-based interventions. The structured days hypothesis posits that structure within a school day plays a protective role for children against obesogenic behaviors, and, ultimately, prevents the occurrence of excessive weight gain. Based on demand-side financing, which has a long history addressing large scale public health problems in the United States through federal, state, and local programs like the Supplemental Nutrition Assistance Program and the 21st Century Learning Centers Program, this study will provide access to healthy structured programming via vouchers to afterschool programs and summer day camps during two “windows of vulnerability” (ie afterschool and summer) for low-income children.

PI_NAMEs: WEAVER, ROBERT G (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Address;Administrator;Adult;after-school program;Age;Behavior;Body fat;Body mass index;Calendar;Child;Communities;cost;cost-effectiveness evaluation;design;Diet;Disparity;disparity reduction;Effectiveness;Environment;excessive weight gain;experience;Family;Fatty acid glycerol esters;Fee-for-Service Plans;Food;food insecurity;fourth grade;good diet;Health;Hour;Household;implementation barriers;Incentives;Income;income disparities;innovation;Intervention;Interview;Learning;learning community;Literature;Low income;lower income families;novel;nutrition;Obesity;obesity in children;obesity treatment;obesogenic;Outcome;Overweight;Parents;Participant;Physical activity;Play;Policies;Prevalence;prevent;primary outcome;program costs;programs;Public Health;Randomized;Recording of previous events;Reporting;Role;Schools;secondary outcome;Services;Side;Sleep;Sleep disturbances;sleep pattern;Structure;summer program;systematic review;Testing;Time;treatment program;United States;United States Department of Agriculture;voucher;Weight;Weight Gain

PROJECT_TITLE: Increasing Low-income Children's Access to Healthy Structured Programming to Reduce Obesity

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Congenital lung diseases are a significant source of pediatric morbidity and mortality for which no definitive treatments exist, although next generation in utero gene therapy may be applied to these disorders to correct pathogenic mutations prior to birth. While animal studies of viral vector delivery of in utero gene therapies are encouraging, identification of alternative, potentially safer delivery approaches will significantly advance the field toward clinical translation. In this proposal, we investigate the potential of ionizable lipid nanoparticles for this application by generating novel mouse fetal lung optimized ionizable lipid nanoparticles.

PI_NAMEs: PALANKI, ROHAN  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acceleration;adenoviral mediated;Affect;Aftercare;AlamarBlue;alpha 1-Antitrypsin Deficiency;Animal Model;Animals;Antibodies;antibody conjugate;Binding;Biocompatible Materials;Biological Assay;Bioluminescence;biomaterial compatibility;Biomedical Engineering;Birth;Blood;Blood Circulation;Campylobacter fetus;cell type;Cells;Charge;Childhood;Cholesterol;Clinical;Clinical Medicine;clinical translation;Complex;Congenital Disorders;CRISPR/Cas technology;curative treatments;Cystic Fibrosis;cytokine;cytotoxicity;delivery vehicle;design;Development;Disease;Dose;Encapsulated;Endocytosis;Environment;Epithelial Cells;Epithelium;Evaluation;experience;Experimental Designs;FDA approved;fetal;Fetal Lung;Fetus;Flow Cytometry;Fluorescence;Formulation;gene editing technology;gene therapy;Genes;genome editing;genotoxicity;Gestational Age;Guide RNA;Harvest;Hospitalization;Hour;Immune system;in utero;in vivo;in vivo imaging system;Inbred BALB C Mice;Inherited;Injections;Intercellular adhesion molecule 1;Lead;lead optimization;Libraries;Life;Lipid Chemistry;lipid nanoparticle;Lipids;Literature;Luciferases;Lung;Lung Diseases;Lung Transplantation;Maleimides;Mediating;medical schools;Mentorship;Messenger RNA;Microfluidics;Modeling;Molecular Abnormality;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;mRNA delivery;Mus;Mutation;nanoparticle delivery;neonatal patient;next generation;novel;novel therapeutics;nucleic acid delivery;Nucleic Acids;Palliative Care;Pathogenicity;Pediatric Hospitals;Pennsylvania;Phenotype;Philadelphia;Phospholipids;Polyethylene Glycols;postnatal;pre-clinical;Property;Protein C Deficiency;Proteins;pulmonary function;Pulmonary Surfactant-Associated Protein C;Reaction;Reporter;Respiration Disorders;Respiratory Disease;Respiratory Failure;Respiratory physiology;reverse genetics;RNA;RNA delivery;Safety;Scheme;Slice;Source;Stains;stem cells;Structure;Surface;surfactant;symposium;Syndrome;System;Testing;Toxic effect;Trachea;Training;Transfection;Universities;uptake;Viral Vector;Work

PROJECT_TITLE: Ionizable Lipid Nanoparticles for Fetal Lung Targeting

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Public Heath Relevance: This proposal will provide us with an understanding of how gamete formation ensures cellular fitness and counteracts cellular aging. The findings have potential impact in the areas of age- associated diseases including cancer and neurodegeneration, regenerative medicine and reprogramming.

PI_NAMEs: UNAL, ELCIN  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Affect;Age;age effect;age related;age-related disease;aged;Aging;aging mechanism;aging process;Area;Behavior;Biochemical;Biological Models;Biology of Aging;Caenorhabditis elegans;Candidate Disease Gene;Cell Aging;Cell Cycle Progression;cell injury;Cell model;Cells;Cellular Morphology;Cessation of life;Chromosomes;Complement;Critical Pathways;Cytoplasm;Dedications;Defect;Deterioration;Development;Disease;Dissection;DNA;Ectopic Expression;egg;Ensure;Eukaryota;Event;Exclusion;experimental study;extend lifespan;Eye;Family;fitness;functional decline;Functional disorder;gain of function;Gametogenesis;gene product;Gene Targeting;Genes;Genetic;Genetic Induction;Genetic Recombination;Germ Cells;Germ Lines;Goals;Growth;hallmarks of aging;Health;healthspan;Homologous Gene;Human;improved;Incentives;insight;life span;Link;live cell microscopy;Longevity;Malignant Neoplasms;Meiosis;membrane biogenesis;Methods;Mitochondria;model organism;Modification;Molecular;Morphogenesis;Nerve Degeneration;novel strategies;Nuclear;Nuclear Pore Complex;Nucleolar Proteins;Oogenesis;Organelles;Pathology;Pathway interactions;Physiological;precursor cell;Predisposition;Production;programs;Proteins;public health relevance;Quality Control;Regenerative Medicine;Regulation;Rejuvenation;Risk Factors;Saccharomyces cerevisiae;Saccharomycetales;segregation;Somatic Cell;sperm cell;Spermatogenesis;System;temporal measurement;Therapeutic;Tissues;TP53 gene;transcription factor;Vacuole;Yeasts

PROJECT_TITLE: Elucidating Cellular Aging and Quality Control Pathways through Meiotic Differentiation

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Myeloproliferative neoplasms (MPN) are clonal blood disorders characterized by overproduction of normal blood cells and an increased risk for progression to bone marrow scarring (fibrosis) or leukemia. Importantly, fibrosis or leukemia in MPN patients is highly lethal. I propose to focus on a key regulator, the High Mobility Group A1 (HMGA1) protein, because our preliminary data strongly suggest that HMGA1 is required for disease progression; my long-term goal is to identify pathways that could be blocked in therapy to treat, or even prevent, progression in patients with MPN.

PI_NAMEs: KIM, YOUNGEUN JOSEPH (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Adult;Age;Aging;Alleles;Back;Blood Cells;Bone Marrow;Cell Cycle Progression;Cells;Chromatin;Cicatrix;Clinical;Clonal Expansion;Colony-Stimulating Factor Receptors;Complex;cytokine;Cytotoxic T-Lymphocytes;Data;Disease;Disease Progression;DNA;Embryonic Development;Engraftment;Feeds;Fibrosis;Fostering;Gene Expression;Gene Expression Regulation;gene function;gene network;gene repression;Genes;Genetic;Genetic Transcription;Goals;Growth;Hematologic Neoplasms;Hematological Disease;Hematopoietic Neoplasms;Hematopoietic stem cells;HMGA Proteins;Human;Hyperactivity;Immune;Immune Evasion;immune function;Immune response;Immunity;Individual;insight;JAK2 gene;Laboratories;Lesion;leukemia;leukemic transformation;Link;Lymphoid Cell;Malignant Neoplasms;Mediating;Mediator;Modeling;mouse model;Mus;mutant;Mutation;Myelofibrosis;Myeloproliferative disease;novel strategies;novel therapeutic intervention;Oncogenes;Oncogenic;Outcome;overexpression;Pathway interactions;Patient-Focused Outcomes;Patients;Phosphorylation;Phosphotransferases;Population;postnatal;prevent;Production;progression risk;Proliferating;promoter;Protein Tyrosine Kinase;Proteins;Publishing;recruit;replication factor C;Risk;Role;Signal Induction;Signal Transduction;Solid Neoplasm;Spleen;STAT protein;STAT3 gene;symptomatic improvement;synergism;Testing;therapeutic evaluation;Tissues;transcription factor;transcriptome sequencing;Treatment Efficacy;tumor progression;uncontrolled cell growth;Up-Regulation;Work

PROJECT_TITLE: Targeting HMGA1-Mediated Progression and Immune Evasion in Myeloproliferative Diseases