NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Health Services;Primary Health Care

PI_NAMEs: MOHR, DAVID CURTIS (contact)

PROJECT_TERMS: Acceleration;Administrator;American;anxiety symptoms;Behavior;Behavior Therapy;Capsicum;Caregivers;Caring;Clinic;Clinical;Communication;Consultations;Cost Savings;Decision Making;Dementia;depressive symptoms;design;Development;Devices;digital health;Disabled Persons;Elements;Evaluation;Evidence based intervention;experience;Face;Failure;Family;Frail Elderly;frailty;Future;Goals;Health Care Costs;health care service;Health Technology;Healthcare Systems;Home;Human;implementation science;improved;innovation;Knowledge;Methodology;Methods;model design;Modeling;multiple chronic conditions;older adult;Outcome;Patients;Pattern;Persons;Pilot Projects;Piper;primary care practice;primary care setting;primary care team;Process;prototype;Randomized, Controlled Trials;Research;Research Personnel;Self Care;service delivery;Services;Technology;technology development;technology intervention;technology validation;Textiles;Translating;Universities;user centered design;Work

PROJECT_TITLE: Healthcare System & Technology Design Core


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE We propose to develop a self-shield kilovoltage x-ray cabinet system with the capabilities of delivering both FLASH and conventional dose-rate irradiations for pre-clinical laboratory research. The novel system, unlike other technologies, make FLASH irradiation broadly available to the research community, which is critical to advance the research and translation of FLASH radiotherapy. FLASH has transformative potential to enhance significantly the efficacy of radiotherapy in cancer treatment.

PI_NAMEs: REZAEE, MOHAMMAD  (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: Animals;Anodes;Biological;cancer therapy;Charge;clinical translation;Collimator;commercialization;Communities;Complex;conventional dosing;conventional therapy;design;design and construction;Development;Dimensions;Dose;Dose Rate;dosimetry;Electron Beam;Electrons;Explosion;Filtration;Fluoroscopy;in vivo Model;industry partner;instrumentation;irradiation;Laboratories;Laboratory Research;Laboratory Study;Legal patent;manufacture;Mechanics;Monte Carlo Method;Normal tissue morphology;novel;Output;particle;Pennsylvania;Performance;Positioning Attribute;pre-clinical;pre-clinical research;Probability;programs;Property;Protons;Radiation;Radiation Dose Unit;Radiation Physics;Radiation therapy;Research;Research Activity;Research Personnel;Robotics;Roentgen Rays;Rotation;Source;System;Systems Development;systems research;Technology;Thick;Toxic effect;Translational Research;Translations;Tube;tumor;Universities;Validation;x-ray irradiation

PROJECT_TITLE: An ultra-high (FLASH) dose rate x-ray cabinet system for pre-clinical laboratory radiation research


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Primary Health Care

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PI_NAMEs: WELTY, LEAH J (contact)

PROJECT_TERMS: accurate diagnosis;Address;adjudication;Aging;American;analytical method;Area;Biometry;burden of illness;Capsicum;Caring;Chronic;Clinical;clinical decision-making;Clinical Sciences;Collaborations;comorbidity;Complex;Data;Data Analyses;Data Analytics;data harmonization;Data Reporting;design;Development;Diagnosis;Disease;Electronic Health Record;experience;Faculty;functional decline;Funding;Health;Health Status;Healthcare;improved;indexing;innovation;Lead;Measurement;Medical;Medical Records;Mentors;Mentorship;Methodology;Methods;Mission;Modeling;Morbidity - disease rate;multiple chronic conditions;multiple data sources;novel strategies;older adult;older patient;Outcome;Patient Care;Patient Outcomes Assessments;Patient Self-Report;Patients;phenomenological models;Population;Primary Care;primary care services;Probability;programs;Quality of life;Recording of previous events;Reporting;Research;Research Design;Research Personnel;research study;Research Support;Resources;Risk;Severities;Source;Statistical Models;Structure;tool;Translational Research;Triage;Universities;voucher

PROJECT_TITLE: Data Analytics Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PI_NAMEs: EROGLU, CAGLA  (contact)

PROJECT_TERMS: Affect;Astrocytes;awake;Behavior;behavior change;Behavioral;Brain;Cell Adhesion;Chemosensitization;cholinergic;Chromatin;Collaborations;Communication;Complement;Complex;CRISPR/Cas technology;Cues;Data;detector;Development;Epigenetic Process;epigenome;Equilibrium;ERG gene;Excitatory Synapse;experience;extracellular;Future;Gene Expression;Genetic;Giant Cells;Goals;histone modification;Image;Immediate-Early Genes;Impairment;in vivo;Individual;Infiltration;Inhibitory Synapse;Instinct;learned behavior;Learning;Link;Measures;Mediating;Memory;Modality;Molecular;molecular modeling;Morphology;multiphoton imaging;Mus;neural circuit;Neuroglia;neuronal circuitry;Neurons;Neuropil;neuroregulation;neurotransmission;Neurotransmitters;noradrenergic;novel;Outcome;Pathway interactions;Performance;Play;Prefrontal Cortex;Property;Proteomics;Reporter Genes;Rewards;Role;Searching Behavior;Sensory;Signal Pathway;Signal Transduction;Structure;Supporting Cell;Synapses;synaptic function;Synaptic Transmission;synaptogenesis;Testing;Time;tool;Training;Transgenic Mice;transmission process;Viral

PROJECT_TITLE: Linking Neuron-Astrocyte Communication to Long-Term Changes in Neural Circuit Function and Behavior


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease

ORG_CITY: WORCESTER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: NARRATIVE Regulated recruitment and migration of acute inflammatory cells termed neutrophils (PMN) into the intestine and across the specialized epithelium that lines it is critical for host defense, yet dysregulation of this process is associated with disease. The goal of this proposal is to examine pathways can drive of pro- and anti-inflammatory states through regulation of PMN transmigration. Results from these experiments will reveal new insights into innate regulation of mucosal inflammation and homeostasis and extensions of this work could lead to targets for experimental therapeutics.

PI_NAMEs: MCCORMICK, BETH A (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: ABCB1 gene;Acute;Address;Agonist;Anti-Inflammatory Agents;Apical;arm;ATP-Binding Cassette Transporters;Bacterial Infections;Biological;Biological Assay;Cannabinoids;Cell surface;Cells;Chemotactic Factors;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CNR2 gene;Colitis;Colon;Communication;Disease;efflux pump;Eicosanoids;endocannabinoid signaling;Ensure;Enteral;Epithelial Cells;epithelial injury;Epithelium;Ethanolamines;Event;experimental study;Family;first responder;follow-up;genome editing;Goals;healing;Health;Homeostasis;Host Defense;Human;Immune;immunoregulation;Immunotherapeutic agent;in vivo Model;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Injury;insight;Intervention;intestinal epithelium;Intestinal Mucosa;Intestines;Invaded;Investigational Therapies;Knock-in;Knock-out;Knowledge;Mediating;member;Microfluidic Microchips;microorganism;migration;Modeling;Molecular;Mucositis;Mucous Membrane;Nature;neutrophil;Neutrophil Infiltration;novel;novel therapeutic intervention;Pathologic;Pathway interactions;Pharmacologic Actions;Pilot Projects;Play;positive allosteric modulator;Process;Protocols documentation;receptor;Receptor Activation;receptor binding;receptor function;recruit;Regulation;Regulatory Pathway;response;restraint;Role;sensor;Severities;Signal Transduction;Stimulus;Submucosa;Surface;System;Testing;Therapeutic Intervention;validation studies;Work

PROJECT_TITLE: Control of Neutrophilic Inflammation in Intestinal Health and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)S]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Health Services;Pain Research;Palliative Care;Primary Health Care

PI_NAMEs: CELLA, DAVID  (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Age;Aging;Algorithms;American;Area;Behavior;Capsicum;Caregivers;Caring;Chicago;Clinical;Collaborations;community center;Complex;Computers;Consultations;Data Collection;design;Development;disability;Education;education research;experience;Faculty;Family;Fatigue;Frequencies;Functional impairment;functional outcomes;functional status;Funding;Health;health care settings;Healthcare;healthy aging;Impaired cognition;improved;Information Dissemination;Information Systems;innovation;International;Intervention;Link;Malignant Neoplasms;Managed Care;Measurement;Measures;Medical;Mentorship;Methodology;Mission;Monitor;multiple chronic conditions;Nausea;older adult;older patient;Outcome;Outcome Assessment;Pain;Patient Monitoring;patient oriented;Patient Outcomes Assessments;Patients;Pilot Projects;preference;Primary Care;primary care clinician;primary care provider;primary care services;primary care setting;Process;Psyche structure;Quality of Care;Quality of life;Research;Research Methodology;Research Support;Resources;Sampling;Services;skills;Social Sciences;symptom management;Symptoms;System;Testing;United States National Institutes of Health;Universities

PROJECT_TITLE: Patient-Reported Outcomes Measurement Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Coronaviruses assembly within cells lining the gut, lung and kidneys uses the apical membrane recycling system and requires a specific interaction between host cell Myosin Vb and the coronavirus M glycoprotein. We now seek to evaluate the basis of the interaction of M protein with Myosin Vb in the recycling system of epithelial cells, and how interruption of this association may decrease efficient virus assembly.

PI_NAMEs: GOLDENRING, JAMES RICHARD (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: 2019-nCoV;Alternative Splicing;Amino Acids;Animals;Apical;apical membrane;Binding;Binding Sites;Biological Assay;Brain;brush border membrane;cell assembly;Cell Line;Cell membrane;Cells;Code;Coronavirus;Coronavirus Infections;COVID-19 pandemic;Cytoplasmic Tail;Diarrhea;Disease;Disease Outbreaks;Elements;Endosomes;Enteral;Enterocytes;Epithelial Cells;Evaluation;Exons;Family;gastrointestinal;Glycoproteins;glycosylation;GTP-Binding Proteins;Heart;Human;human coronavirus;Hybrids;Infection;Interruption;Intervention;Intestinal Mucosa;Intestines;Kidney;Lead;Length;Link;live cell imaging;Lung;Lung Diseases;MDCK cell;Membrane;Middle East Respiratory Syndrome;Middle East Respiratory Syndrome Coronavirus;Monomeric GTP-Binding Proteins;Mouse Protein;Mucous Membrane;multiple myeloma M Protein;Murine hepatitis virus;Mutagenesis;Mutation;MYO5A gene;Myosin ATPase;Organoids;pathogenic virus;Pathogenicity;Pathway interactions;Pattern;Point Mutation;porcine epidemic diarrhea virus;protein transport;Proteins;Recycling;Regulation;Reporting;Resolution;respiratory;RNA Splicing;Role;scaffold;screening;Severe Acute Respiratory Syndrome;Site;small molecule;Symptoms;System;Tail;targeted treatment;Testing;Tetracyclines;Tissues;trafficking;Transmembrane Domain;Ubiquitin;Validation;Variant;Vesicle;Viral;Viral load measurement;Viral Proteins;Virion;Virus;Virus Assembly;virus host interaction;Virus-like particle;yeast two hybrid system;Yeasts

PROJECT_TITLE: Small GTP Binding Proteins in Gastrointestinal Mucosa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


NIH_SPENDING_CATS: Aging;Clinical Research;Health Services;Networking and Information Technology R&D (NITRD);Primary Health Care

PI_NAMEs: ACKERMANN, RONALD T. (contact)

PROJECT_TERMS: Adoption;Aging;American;Area;Bibliometrics;Capsicum;Caregivers;Caring;Chicago;Chronic Disease;Clinical;Clinical Sciences;Collection;Communication;Communities;community engagement;Community Healthcare;community organizations;Complement;Coupled;design;Development;Disease Outcome;dissemination strategy;education research;eHealth;Elderly;Electronic Health Record;Electronics;Evaluation;evidence base;Evidence based practice;Faculty;Feedback;Goals;Growth;Health;health care service organization;Health Policy;Health Services Research;Health system;Healthcare;Healthcare Systems;Home;improved;Individual;Information Centers;Information Dissemination;Infrastructure;innovation;Institution;Internet;Intervention;Lead;Leadership;Learning;Managed Care;Medicine;mHealth;Modeling;multiple chronic conditions;Neighborhood Health Center;novel;novel strategies;older adult;Outcome Measure;Outcomes Research;Output;outreach;Participant;Patients;Persons;Policies;Policy Maker;Practice Management;preference;Preparation;Primary Care;primary care services;Privatization;Process;Professional Organizations;Public Health;Publishing;Quality of life;repository;Research;Resources;symposium;systems research;Technology;technology platform;Time;Translational Research;Translations;United States Agency for Healthcare Research and Quality;Universities;usability;Work

PROJECT_TITLE: Information Dissemination Core


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Pancreatic cancer is a deadly disease, in part, because the cancer cells are able to recruit non-cancerous cells called “fibroblasts” that in turn can help the cancer cells grow and evade therapies. The purpose of this study is to better understand how these non-cancerous fibroblast cells change during the development of pancreatic cancer, how different types of noncancerous cells contribute to tumor growth, and how we can develop new drugs to prevent these cells from aiding the cancer cells. This work will identify new ways to block the cancer- promoting, fibroblast cells, which could lead to new treatments for patients affected by pancreatic cancer.

PI_NAMEs: TUVESON, DAVID A (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Ablation;Address;Affect;Alleles;analytical method;Antigen Presentation;Biology;cancer cell;Cell Survival;Cells;Cellular Assay;Chemoresistance;Chromatin;Clinical Research;Coculture Techniques;combinatorial;Complex;Computational Biology;Computer Analysis;Computing Methodologies;curative treatments;Cytometry;Cytotoxic T-Lymphocytes;Desmoplastic;detection method;Development;Disease;Disease Progression;Drug Delivery Systems;effective therapy;Fibroblasts;Genes;Genetic Complementation Test;Genetic Transcription;Heterogeneity;Histologic;Human;IL1R1 gene;Image;Immune;immune checkpoint;immune checkpoint blockade;immunoregulation;Immunosuppression;Immunotherapy;improved;In Situ;Inflammatory;KPC model;KRAS oncogenesis;KRAS2 gene;Ligands;Machine Learning;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediator;Metastatic Neoplasm to the Liver;Methods;Mitogens;Modeling;mouse model;Mus;mutant;Mutation;novel;novel therapeutic intervention;novel therapeutics;Organoids;Outcome;pancreas development;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;paracrine;Paracrine Communication;Pathway interactions;patient prognosis;Patients;pharmacologic;Pharmacotherapy;Phenotype;Population;preclinical study;prevent;progenitor;Property;Proteins;recruit;Regimen;Regulatory Element;Research;Resistance;Resolution;restraint;RNA;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;Specimen;T cell infiltration;T-Lymphocyte;Target Populations;Testing;Therapeutic;therapeutic target;therapy design;Tissues;tool;transcriptomics;Translating;transplant model;Transposase;tumor growth;tumor progression;Tumor Promotion;tumor-immune system interactions;Work;Xenograft Model

PROJECT_TITLE: Fibroblast Heterogeneity in Pancreatic Cancer

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Neurosciences;Substance Misuse

PI_NAMEs: TIAN, LIN  (contact)

PROJECT_TERMS: Acetylcholine;Address;Affect;Astrocytes;awake;Axon;Behavior;Behavioral;Biology;Biosensor;Brain;Calcium;calcium indicator;Cell Adhesion Molecules;cell type;cognitive process;Color;Communication;Complex;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;design;Development;Dopamine;Engineering;Equilibrium;Excitatory Synapse;experience;experimental study;extracellular;Fluorescence;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;genetic manipulation;genomic profiling;Glutamates;Image;imaging system;improved;in vivo;Individual;Infiltration;Inhibitory Synapse;Investigation;Knowledge;Label;Lead;Measures;Mind;minimally invasive;Modeling;Modernization;Molecular;multidisciplinary;multiplexed imaging;Mus;neural circuit;Neuromodulator;neuronal circuitry;Neurons;neuroregulation;Neurotransmitters;novel;novel strategies;optogenetics;Pathology;Pathway interactions;Pattern;Pharmaceutical Preparations;Phosphotransferases;postsynaptic neurons;presynaptic;Process;Property;Protein Engineering;Proteins;reconstitution;redshift;Resolution;Resources;response;Role;screening;sensor;Serotonin;Shapes;Signal Pathway;Signal Transduction;Slice;spatiotemporal;Stimulus;Supporting Cell;Synapses;synaptic function;Synaptic Transmission;synaptogenesis;Techniques;Technology;Testing;tool;two photon microscopy;two-photon

PROJECT_TITLE: Novel Genetically Encoded Indicators for Interrogating Neuron-Astrocyte Communication Across Timescales


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Project Narrative The objective of this study is to better understand the underlying neurophysiology associated with motion processing deficits in cerebral (cortical) visual impairment (CVI). CVI is the leading cause of congenital visual impairment in the developed world yet, little is known as to how visual perceptual deficits in these individuals relate to early maldevelopment of central visual pathways and structures. We will carry out psychophysical behavioral testing combined with multimodal neuroimaging to characterize brain-behavioral relationships associated with motion processing deficits; which is an important marker of developmental vulnerability.

PI_NAMEs: MERABET, LOTFI  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Adolescent;Anisotropy;Attention;Behavior assessment;behavior test;Behavioral;blood oxygen level dependent;Brain;cerebral visual impairment;Cerebrum;Child;Child Care;Clinical assessments;clinical development;community involvement;comparison control;Complex;design;Development;Diffusion;Dorsal;dorsal visual stream;Education;Environment;Eye Movements;Fiber;Functional disorder;Functional Magnetic Resonance Imaging;gaze;Image;imaging approach;Impairment;indexing;Individual;innovation;insight;Interdisciplinary Study;interest;Investigation;Length;Magnetic Resonance Imaging;Motion;Motion Perception;Multimodal Imaging;multimodal neuroimaging;multimodality;Nature;Network-based;neural correlate;neuroimaging;neurological rehabilitation;Neuronal Plasticity;neurophysiology;Outcome;Outcome Measure;Parietal;Participant;Pathway interactions;Pattern;Performance;Perinatal;Periventricular Leukomalacia;Population;Predisposition;programs;Psychophysics;Rehabilitation therapy;Reporting;Research;Resolution;response;Rest;secondary outcome;Signal Transduction;statistics;Stream;Structure;Testing;Time;United States;ventral visual stream;virtual reality;virtual reality simulation;Visual;Visual attention;Visual impairment;Visual Motion;Visual Pathways;visual processing;Visual Psychophysics;visual search;Visual System;white matter

PROJECT_TITLE: Neurophysiological Correlates of Visual Motion Processing in Cerebral Visual Impairment

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: NEW ORLEANS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Post-tuberculosis lung disease (PTLD), which develops in up to half of people with pulmonary tuberculosis, is an increasingly recognized cause of lung disease with up to 4.3 million new cases worldwide every year. However, the underlying biologic mechanisms that lead to PTLD are still poorly understood. This proposal aims to understand the underlying clinical host factors and host immunological factors that lead to PTLD, measuring lung function over two-years after pulmonary tuberculosis and using state-of-the art techniques including RNA sequencing.

PI_NAMEs: ZIFODYA, JERRY S. (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acute-Phase Reaction;Adult;Africa South of the Sahara;Aftercare;Antigens;Award;Bioinformatics;Biological;Biological Assay;Biological Markers;biomarker identification;C-reactive protein;career;Characteristics;chemokine;Chronic;circulating biomarkers;Clinical;cohort;Cohort Studies;Complement;Consequences of HIV;Cross-Sectional Studies;CXCL9 gene;Data;Development;Discipline;DNA;Enrollment;Enzyme-Linked Immunosorbent Assay;Epidemiology;Female;follow-up;genetic risk factor;Genetic Transcription;Goals;Hepatic;HIV;HIV Infections;immune activation;Immunocompromised Host;Immunogenetics;Immunologic Factors;Immunologic Markers;Immunologics;Immunology;Impairment;improved;Individual;Infiltration;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Integration Host Factors;Interdisciplinary Study;Interferon Type I;Interferons;International;Intervention;K-Series Research Career Programs;Kenya;Knowledge;Literature;Longitudinal cohort;Longitudinal Studies;Lung;Lung Diseases;lung injury;Measurement;Measures;Medical Research;Mentors;Mentorship;Modeling;Morbidity - disease rate;mortality;Neutrophil Collagenase;Newly Diagnosed;Opportunistic Infections;Outcome;Participant;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Physicians;Plasma;Positioning Attribute;Predictive Factor;prevent;profiles in patients;programs;prospective;Prospective Studies;Proteins;Public Health Schools;Publishing;pulmonary function;pulmonary function decline;Pulmonary Tuberculosis;Recording of previous events;Research;Research Institute;Research Methodology;Research Personnel;Research Training;Resource-limited setting;respiratory;response;responsible research conduct;Risk;Risk Factors;Sampling;Science;Scientist;sex;Signal Transduction;Spirometry;statistics;Symptoms;Techniques;Testing;Time;TNF gene;Training;transcriptome sequencing;transcriptomics;Tropical Medicine;Tuberculosis;tuberculosis treatment;Universities;Up-Regulation;Washington;Work

PROJECT_TITLE: Clinical and biologic risk factors for post-tuberculosis lung disease (PTLD) in people with and without HIV

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRAVIVE  The proteasome is the central protease in our cells, and as such it controls the levels, and therefore the functionality, of hundreds of proteins. We know from model organism studies that the activity of the proteasome promotes longevity as well as ameliorates some mechanisms of neurodegeneration. In this study, we will develop an understanding of key mechanisms that control the activity of the proteasome.

PI_NAMEs: FINLEY, DANIEL J (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Affect;Binding;Caenorhabditis elegans;Cells;Complex;Deubiquitinating Enzyme;Disease;Enzymatic Biochemistry;Enzymes;Eukaryota;extend lifespan;fascinate;Genetic;genetic analysis;Impairment;interest;Laboratories;Longevity;Mediating;Methods;model organism;multicatalytic endopeptidase complex;mutant;Nerve Degeneration;Output;Pathway interactions;Peptide Hydrolases;Perception;polyglutamine;Proteins;Proteomics;proteostasis;receptor;reconstitution;recruit;Regulation;Reporting;Role;single molecule;Specificity;Stress;structural biology;Structure;Substrate Specificity;System;Time;Ubiquitin;ubiquitin isopeptidase;ubiquitin ligase;Work;Yeasts

PROJECT_TITLE: Regulation of Proteasome Activity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Atlanta Network for Training in KUH Scientific Research (ATLANTIS) is an Institutional Network Award for Promoting Kidney, Urologic, and Hematologic Research Training in Atlanta. Our goal is to create an institutional resource for training the next generation of researchers for the study of kidney, urology, and hematologic (KUH) diseases. ATLANTIS will bring together trainees at multiple career stages who are interested in furthering their scientific research training and pursuing a career in biomedical research.

PI_NAMEs: WALL, SUSAN MARIE (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Address;Affect;Award;Awareness;Biomedical Engineering;Biomedical Research;Calendar;career;Career Choice;career development;career preparation;Chronic Kidney Failure;Cities;Clinical;Clinical Sciences;cloud based;Collaborations;college;Communication;Communities;Competence;Computer software;Coupled;design;Development;digital;disadvantaged background;disadvantaged student;Discipline;Disease;Economic Burden;Education;Educational process of instructing;Engineering;Environment;ethnic minority;experience;Faculty;Fostering;Goals;graduate school;Health;health care availability;Health Personnel;Healthcare;Hematological Disease;Hematology;high school;Historically Black Colleges and Universities;Home;Human;human disease;Individual;Infrastructure;innovation;Institution;interdisciplinary collaboration;interest;Investigation;Kidney;Kidney Diseases;learning community;Medical;medical specialties;member;Mentors;Mentorship;metropolitan;minority trainee;Morehouse School of Medicine;Nephrology;next generation;novel;outreach;outreach program;Pathway interactions;Patients;peer;peer coaching;peer networks;Personal Growth;Persons;Postdoctoral Fellow;pre-doctoral;Program Development;programs;Qualifying;racial disparity;racial minority;recruit;Research;research faculty;Research Personnel;Research Training;Resources;Science;Scientist;Sickle Cell Anemia;skills;social disparities;social media;Societies;socioeconomics;STEM career;strength training;Structure;success;support network;Surveys;System;Technology;TNFSF15 gene;Training;Translational Research;Underrepresented Minority;underrepresented minority student;Universities;Urinary tract infection;urologic;Urologic Diseases;Urology;Vision;web site;Woman

PROJECT_TITLE: Atlanta Network for Training In KUH Scientific Research (ATLANTIS)


NIH_SPENDING_CATS: Hematology;Kidney Disease

PI_NAMEs: SANDS, JEFF M (contact)

PROJECT_TERMS: Address;Adherence;Advisory Committees;Award;base;Biomedical Research;Budgets;career;Career Choice;career development;Chronic;Chronic Kidney Failure;Cities;Clinical;clinical care;Collaborations;college;Communication;Dedications;design;Development;disadvantaged background;disadvantaged student;Disease;Economic Burden;Education;education resources;Educational process of instructing;Engineering;Ensure;Environment;equity, diversity, and inclusion;Evaluation;Exposure to;Fellowship;formative assessment;Fostering;Funding;Goals;Growth;Health;Hematological Disease;Hematology;high school;Historically Black Colleges and Universities;Hospitalization;Human;human disease;Infrastructure;innovation;Institution;interest;Investigation;Kidney;Knowledge;Leadership;Logistics;Medical;meetings;Mentors;Minority Groups;Mission;Monitor;Morehouse School of Medicine;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;Nephrology;next generation;novel strategies;outreach program;Pathway interactions;peer;Postdoctoral Fellow;pre-doctoral;Program Development;Program Effectiveness;Program Evaluation;Program Reviews;programs;Qualifying;recruit;Reporting;Research;Research Personnel;Research Support;Research Training;Resources;Science;Scientist;Sickle Cell Anemia;STEM career;Strategic Planning;strength training;success;symposium;Technology;TNFSF15 gene;Training;Training Programs;Underrepresented Minority;underrepresented minority student;Universities;urologic;Urology;Vision;Woman


ADMINISTERING_IC: HD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: TALLAHASSEE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE This project will uncover the mechanisms through which COVID-19 has and will have short-term and long-term impacts on children’s reading skills. We use a risk-resilience model as the framework for this project, which recognizes children have varying levels of risk factors that make them more or less likely to be affected by COVID-19 related disruptions to their sources of resiliency. This project will help us understand how the COVID-19 pandemic is affecting children, as well as add to our general knowledge about how trauma affects children.

PI_NAMEs: HART, SARA ANN;LITTLE, CALLIE  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Academic achievement;Achievement;Address;Affect;Age;Attention;Censuses;Child;Cognitive;cohort;community center;Computers;COVID-19;COVID-19 impact;COVID-19 pandemic;Data;Data Collection;digital;digital divide;digital technology;Economic Conditions;economic impact;Economics;elementary school;Enrollment;Environment;Equilibrium;Ethnic Origin;experience;Family;Family history of;Family member;family structure;Food;fourth grade;Gender;Geography;Goals;Grant;Health;Home;Housing;Impairment;Instruction;instructor;Internet;kindergarten;Knowledge;Learning;Learning Disabilities;Libraries;Link;Location;long term consequences of COVID-19;Long-Term Effects;Longitudinal Surveys;Measurement;Measures;Mediating;Mental disorders;Mental Health;Mentors;Methods;Modeling;Monitor;neighborhood disadvantage;Occupations;Outcome;pandemic disease;Parents;Pathway interactions;peer;Peer Group;Personal Satisfaction;Persons;physical conditioning;pre-pandemic;Procedures;Questionnaires;Race;racial discrimination;Reading;reading ability;reading difficulties;recruit;Research;resilience;resilience factor;Resources;Risk;Risk Factors;Role;Sampling;school closure;Schools;Services;Severities;skills;social;Social Interaction;Socioeconomic Status;socioeconomics;Source;Speed;Stress;stressor;Surveys;teacher;Technology;Testing;Time;Trauma;Twin Multiple Birth;UNESCO;Work

PROJECT_TITLE: Assessing the links between risk factors, COVID-19 impacts, and reading skills

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


PI_NAMEs: BROWN, LOU ANN S (contact)

PROJECT_TERMS: Address;Area;Award;Biomedical Research;Biometry;Businesses;career;career development;Career Exploration;Communication;Communities;Contracts;Creativeness;design;Development;digital platform;Doctor of Medicine;Doctor of Philosophy;Education;educational atmosphere;Educational workshop;equity, diversity, and inclusion;experience;Faculty;flexibility;Fostering;Freedom;Funding;Future;Goals;graduate student;Grant;Hematological Disease;Hematology;Hour;Individual;innovation;Inosine Diphosphate;Institution;interest;Kidney;Laboratories;Lead;Leadership;leadership development;Learning;lectures;meetings;member;Mentors;multidisciplinary;National Institute of General Medical Sciences;next generation;Oral;oral communication;peer;Postdoctoral Fellow;pre-doctoral;pressure;prevent;programs;Readiness;Research;research faculty;Research Personnel;Research Training;Resources;Role;Schools;Scientist;Series;Sexual Harassment;Shapes;skill acquisition;skills;social media;Social Network;Societies;success;Teacher Professional Development;Time;timeline;TNFSF15 gene;Training;Training Programs;urologic;Urology;Vocational Guidance;Work;Writing


NIH_SPENDING_CATS: Contraception/Reproduction;Electronic Nicotine Delivery Systems;Infertility;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Tobacco;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Results from this project can provide foundational understanding describing the safety of e-cigarette use during pregnancy. These studies offer a valuable resource to the public health community defining the impact of e-cigarettes on early pregnancy success and fetal health. Furthermore, deepened understanding of factors affecting early pregnancy can benefit the treatment of women suffering from infertility, early pregnancy loss, or hypertensive pregnancy disorders.

PI_NAMEs: MARBREY, MARGEAUX WETENDORF (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: aerosolized;Affect;Agonist;antagonist;Arteries;Benchmarking;Biological Process;Buffers;Cell Differentiation process;Cell Physiology;Cells;Cessation of life;chemokine;chemokine receptor;cigarette smoking;Communication;Community Health;Complex;CXCR4 Signaling Pathway;Dangerousness;Data;Decidua;Delayed Embryo Implantation;early pregnancy;early pregnancy loss;Electronic cigarette;electronic cigarette use;Electronic Nicotine Delivery Systems;Embryo;Embryo Transfer;Embryonic Development;Endometrial;Enzymes;Epithelium;Euthanasia;Event;Exhibits;experience;experimental study;Exposure to;Faculty;failure Implantation;Fertility;Fertility Rates;fetal;Fetal Death;Fetal Growth Retardation;Fetal health;Fetal Weight;Flavoring;Gene Expression;Goals;Hormonal;hormonal signals;Human;hypertensive;Immune;immunoregulation;Impairment;implantation;improved;In Vitro;in vitro Model;in vivo;Infertility;Inhalation;Invaded;knock-down;Knowledge;Laboratories;Liquid substance;Litter Size;malformation;Measures;Mediating;migration;Modeling;Molecular;Mus;natural Blastocyst Implantation;Nicotine;Organoids;Pathology;Pathway interactions;Patients;Placenta;Placentation;Positioning Attribute;Pregnancy;pregnancy disorder;Pregnant Women;Process;Proliferating;Propylene Glycols;Prostaglandins;protein expression;Public Health;Publishing;recruit;Recurrence;Regulation;Reporting;reproductive fitness;reproductive system disorder;Research;Resources;Safety;Sampling;Signal Pathway;smoking during pregnancy;Spiral Artery of the Endometrium;Spontaneous abortion;stillbirth;Stromal Cell-Derived Factor 1;Stromal Cells;success;Supplementation;tenure track;Testing;Time;Tissues;Toxic effect;toxicant;transcriptomics;trophoblast;uterine receptivity;Uterus;vapor;Vascular Permeabilities;vegetable glycerin;Vitamin E Acetate;Woman;women's treatment

PROJECT_TITLE: Investigating Implications of E-Cigarettes on Pregnancy Success and Reproductive Fitness

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


PI_NAMEs: HEILMAN, STACY STEPHANS (contact)

PROJECT_TERMS: Address;Area;Award;Biomedical Research;career;Career Choice;career development;Collaborations;college;Communication;Communication Tools;Communities;Community Networks;Community Outreach;Custom;Dedications;Democracy;design;digital;digital platform;Discipline;Education;Environment;Event;experience;Exposure to;Face;Faculty;Fostering;Future;Generations;Goals;Health;Hematological Disease;Hematology;high school;Historically Black Colleges and Universities;innovation;innovative technologies;Institution;interdisciplinary collaboration;interest;Internet;Kidney;Leadership;learning community;learning network;medical schools;Mentors;Mentorship;metropolitan;Minority Recruitment;Mission;Modernization;Morehouse School of Medicine;Names;Nephrology;next generation;Non-Malignant;notch protein;novel;outreach program;Participant;peer;peer coaching;peer networks;Persons;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Production;programs;Publishing;recruit;Research;Research Personnel;Research Project Grants;Research Training;Residencies;Resource Development;Resources;Science;Scientist;Structure;success;support network;Talents;Thinking;Training;Training Programs;undergraduate student;Universities;urologic;Urology


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: MILWAUKEE

ORG_NAME: AURORA HEALTH CARE, INC.

ORG_STATE: WI

PHR: PROJECT NARRATIVE The Aurora NCORP community site will enroll patients in an expanded portfolio of NCI-sponsored clinical trials. The program is built on a foundation of high-quality cancer care, an experienced leadership structure and a strong clinical research infrastructure.

PI_NAMEs: HALLMEYER, SIGRUN ;SAPHNER, THOMAS J (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Adolescent;Adult;Advocate;Aftercare;cancer care;Cancer Control;cancer health disparity;Cancer Patient;Cardiology;care delivery;Childhood;Clinical Research;Clinical Trials;Communities;Community Outreach;Country;Disparity population;Electronic Health Record;Enrollment;experience;Foundations;Goals;Health;Health system;Health Technology;Healthcare;Hospitals;Illinois;Image;improved;Leadership;Location;Malignant Childhood Neoplasm;medical specialties;multidisciplinary;Newly Diagnosed;Oncology;oncology trial;Outcomes Research;participant enrollment;Patient-Focused Outcomes;Patients;Pediatric Hospitals;Pediatric Research;Prevention;programs;Research;Research Infrastructure;Research Institute;Resource Sharing;Resources;screening;Services;Site;Structure;System;Time;Underrepresented Populations;Wisconsin;Work;young adult

PROJECT_TITLE: Aurora NCORP Community Site


ADMINISTERING_IC: LM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: HARVARD UNIVERSITY

PHR: This proposal seeks to establish an Al-driven "cyborg tissue" platform that integrates flexible electronic  sensors and actuators with developing human-induced pluripotent stem cell (hiPSC)-derived cardiac  tissues for monitoring and controlling tissue maturation. The closed-loop system will collect multimodal  electrical, mechanical, and genetic data from cells, analyze the data using statistical models, and  generate control policies through reinforcement learning to promote tissue maturation via distributed electrical actuations. By improving our understanding of how genetic, molecular, electrical, and mechanical  processes regulate hiPSC-derived cardiac organoid maturation, this resulting bioelectronics system will have  wide-ranging applications in regenerative medicine and pharmacology.

PI_NAMEs: DING, JIE ;LI, NA ;LIU, JIA  (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: 3-Dimensional;Acceleration;Algorithms;Architecture;Artificial Intelligence;bioelectronics;Biological Models;biomaterial compatibility;biomedical informatics;Biophysics;Cardiac;Categories;Cell Maturation;Cells;Chronic;Computational Biology;course development;Data;data integration;Development;E-learning;Electric Stimulation;electronic sensor;Electronics;empowerment;Evaluation;Evolution;Experimental Designs;Feedback;flexibility;flexible electronics;Gene Expression;Genes;Genetic;Genetic Markers;Goals;human induced pluripotent stem cells;Implant;improved;In Situ;in vivo;Intervention;Joints;Learning;learning strategy;Machine Learning;Maps;mathematical model;Measurement;mechanical signal;Mechanics;miniaturize;Mission;Modality;Modeling;Molecular;molecular phenotype;Monitor;multimodal data;multimodality;nanoelectronics;novel;Organoids;Patients;pharmacologic;Pharmacology;Policies;predictive modeling;Process;Property;Psychological reinforcement;Regenerative Medicine;Research;Resolution;Rewards;Scientist;sensor;Signal Transduction;single-cell RNA sequencing;Site;spatiotemporal;statistical learning;Statistical Models;stem cell derived tissues;stem cells;success;synthetic biology;System;Technology;Testing;Time;Tissue Embedding;Tissue Engineering;Tissue Sample;Tissues;tool;trustworthiness;United States National Library of Medicine;Variant;virtual;Work

PROJECT_TITLE: SCH: Al-driven Flexible Electronics for Cardiac Organoid Maturation


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention

ORG_CITY: EAST LANSING

ORG_DEPT: PEDIATRICS

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE The primary goal of the current application is to determine how genetic factors influence the development of brain structure and function in infancy and early childhood. Several major disorders emerge during this period, including autism and ADHD, and altered brain development at this early stage may increase risk for later-onset disorders such as schizophrenia. This project will provide new insights into the developmental origins of psychi- atric disease and inspire an exciting new line of research focused on preventing psychiatric conditions through very early intervention in at-risk individuals.

PI_NAMEs: KNICKMEYER, REBECCA  (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Aggressive behavior;Alzheimer's Disease;Anxiety;Area;Asia;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Behavior assessment;behavior measurement;Behavioral;behavioral phenotyping;behavioral study;Biological;Birth;Brain;brain circuitry;Brain scan;Caring;Child;Child Behavior;Childhood;Clinical;clinical care;cohort;Complex;Data;Data Set;Development;Diagnostic;Diffusion Magnetic Resonance Imaging;disability;Disease;disorder risk;DNA;early childhood;Early identification;Early Intervention;Ethnic Origin;Europe;executive function;Fiber;functional genomics;Functional Magnetic Resonance Imaging;Future;Genes;Genetic;Genetic Risk;genetic variant;Genome;Genome Scan;genome wide association study;Genomic approach;genomic data;Genomics;Goals;Growth;Haplotypes;Heritability;high risk;Human;Image;Impulsivity;indexing;Individual;infancy;Infant;innovation;insight;instrument;Late-Onset Disorder;Libraries;Life;Link;longitudinal design;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mental disorders;Methods;Michigan;Modeling;Molecular;Multivariate Analysis;nervous system development;neural circuit;neurodevelopment;neuroimaging;new therapeutic target;novel;novel therapeutics;Outcome;Participant;Pathologic;Pathway interactions;Pattern;Pediatric cohort;Phenotype;prevent;Prevention;Preventive Medicine;Process;prophylactic;Protocols documentation;psychiatric genomics;Quality Control;Research;Research Personnel;Resources;Rest;Risk;risk variant;Scanning;Schizophrenia;Severities;Single Nucleotide Polymorphism;Site;Source;South Africa;Structure;Surface;Symptoms;Testing;Thick;Time;tool;trait;trait impulsivity;United States;Variant

PROJECT_TITLE: Genetic Influences on Infant Brain Development: Understanding the Developmental Origins of Mental Illness

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Rural Health;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Although sexual and gender minorities (SGM) experience among the largest mental health disparities of any population, evidence-based mental health practice specifically targeting this population's distinct stressors and stress responses has been unavailable until recently. Now that LGBTQ-affirmative CBT has shown effectiveness across several trials and generated high demand, implementation science is needed to determine optimal nationwide implementation strategies. This study will identify optimal means through which to implement this treatment innovation in the US's large network of LGBTQ community centers, thereby producing generalizable guidance for EBP implementation across low-resource settings nationwide in which mental health disparities populations are likely to seek treatment.

PI_NAMEs: PACHANKIS, JOHN EDWARD (contact)

PROGRAM_OFFICER_NAME: MAVANDADI, SHAHRZAD

PROJECT_TERMS: Address;Adoption;biological adaptation to stress;budget impact;Budgets;career;Caring;Characteristics;Client;Climate;Clinical Trials;Code;Cognitive Therapy;community center;community setting;compare effectiveness;Competence;Consolidated Framework for Implementation Research;Consultations;coping;cost;Data;demographics;depressive symptoms;Disparity population;E-learning;effective therapy;Effectiveness;effectiveness outcome;evidence base;Evidence based intervention;Evidence based practice;experience;Future;gender minority community;gender minority group;health disparity;health disparity populations;health equity;Health Personnel;health practice;Hybrids;implementation determinants;implementation outcomes;Implementation readiness;implementation science;implementation strategy;improved;Individual;innovation;Interview;Knowledge;learning materials;Lesbian Gay Bisexual Transgender Queer;Maintenance;Measures;Mediating;Mediation;Mental Health;Mental Health Services;Methods;Outcome;Pathway interactions;peer;people of color;Pilot Projects;Policies;Population;Provider;provider factors;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Resource-limited setting;Risk;rural area;Self Efficacy;Series;Sexual and Gender Minorities;sexual minority group;skills;social cognitive theory;social stigma;Societies;Stress;stressor;success;Supervision;Supportive care;Surveys;systematic review;Target Populations;theories;Trainers Training;Training;Training Support;transgender;Uninsured;volunteer;webinar;Workplace

PROJECT_TITLE: Implementing sustainable evidence-based mental healthcare in low-resource community settings nationwide to advance mental health equity for sexual and gender minority individuals

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Pediatric;Prevention;Serious Mental Illness;Sleep Research;Suicide;Suicide Prevention

ORG_CITY: PISCATAWAY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Adolescent suicide and suicidality have increased in recent years, which parallels the advent and rapid growth of social media use in adolescents’ daily lives. The proposed study will be the first in a broader program of research that leverages smartphone technology to examine how social media use impacts risk for the development and worsening of suicidal ideation and behavior among adolescents. This research program aims to identify modifiable risk factors, including social media use and sleep disruption, for adolescent suicide risk, and ultimately, contribute to the development of interventions that are personalized, scalable, and delivered in real time to prevent suicide.

PI_NAMEs: HAMILTON, JESSICA LEIGH (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: actigraphy;Address;Adolescent;Adolescent Development;adolescent suicide;Affect;Affective;Age;Arousal;Attenuated;Beds;Behavior;boys;career;Cause of Death;Cellular Phone;child depression;Clinical;clinically actionable;Cognitive;Data;Depressed mood;depressive symptoms;design;Development;digital media;Ecological momentary assessment;Environment;Feeling suicidal;Foundations;Future;girls;Goals;Growth;Health;high dimensionality;high risk;high-risk adolescents;ideation;innovation;Instagram;Interview;Link;Longitudinal Studies;machine learning algorithm;Measures;media use;Mediating;Mental Depression;Mental Health;Mentors;Mentorship;Methodology;Methods;mobile computing;mobile sensing;Modeling;modifiable risk;Monitor;Moods;mortality;Nature;novel;Outcome;Participant;Pathway interactions;Patient Self-Report;Pattern;personalized intervention;Persons;Population;Positioning Attribute;prevent;Prevention;Prevention program;programs;prospective;Prospective Studies;Psychiatry;Public Health;rapid growth;recruit;Research;Research Personnel;Risk;Risk Factors;Sampling;Scientist;secondary analysis;sex;Silk;skills;Sleep;Sleep disturbances;sleep onset;social;social media;statistical and machine learning;statistics;success;suicidal;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide prevention;supervised learning;Techniques;Technology;Telephone;Testing;therapy development;Time;Training;Universities;Visit;Youth

PROJECT_TITLE: The impact of social media use on precursors of adolescent suicide risk: Aprospective study


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_NAME: INFINITE BIOMEDICAL TECHNOLOGIES, LLC

PHR: PROJECT NARRATIVE The mission of our company is to improve the lives of individuals with upper limb loss (ULL). In this project, we hope to empower the user by enabling improved control over their prosthesis. Specifically, this project is focused on a system to allow the user to start training for how to contract their residual muscles in order to generate signals which are sensed and interpreted by their prosthesis in order to drive the motors which control it. This is particularly important since currently there is not a system which is available to individuals before their prosthesis is fabricated, and this is the very time period in which training is the most valuable.

PI_NAMEs: KALIKI, RAHUL REDDY (contact)

PROGRAM_OFFICER_NAME: WU, GUANGYING

PROJECT_TITLE: Regulatory clearance of a rehabilitation system for individuals with upper limb loss


NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

PI_NAMEs: LIU, SIRU  (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: Academic Medical Centers;Address;Affect;Body Weight decreased;Cardiopulmonary Resuscitation;career;career development;Clinical;clinical decision support;Data;design;Development Plans;Electronic Health Record;Equity;experience;explainable artificial intelligence;Fatigue;Federal Government;Feedback;Healthcare Systems;Human;improved;Learning;Logic;Machine Learning;Manuals;Methods;neglect;patient safety;Phase;predictive modeling;Process;Recommendation;Research;response;skills;standardized care;Suggestion;support tools;Taxonomy;Techniques;Text

PROJECT_TITLE: Optimizing Clinical Decision Support Alerts Using Explainable Artificial Intelligence (XAI)


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Clinical Research;Headaches;Migraine;Neurosciences;Pain Research

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Exposure to a narrow band of green light (nbGL) is capable of reducing headache intensity, photophobia and anxiety caused by a migraine attack. The proposed studies will provide insight to how nbGL affects the hyperexcitable cortex in (a) ictal and (b) interictal migraineurs; the non- hyperexcitable cortex in (c) healthy controls; and in a widely studied animal model of migraine. If successful, it will provide a mechanistic basis for a novel therapeutic approach that is not invasive, risk-free, and affordable.

PI_NAMEs: BURSTEIN, RAMI  (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Acute;Affect;Affective;Amber;Anesthesia procedures;animal data;Animal Disease Models;Animal Model;Anxiety;Area;Attenuated;Auras;Aversive Stimulus;awake;Basic Science;Brain;Characteristics;Clinical;Clinical Data;Clinical Research;Clinical Sciences;Cognitive;Color;Complex;Darkness;Data;Development;Disease;Electrocorticogram;Electrophysiology (science);Emotional;Event;experience;Exposure to;Female;Frequencies;frontal lobe;functional near infrared spectroscopy;Goals;Headache;Hour;Human;human subject;insight;Knowledge;Light;light effects;male;Measures;Medial;member;Methods;Migraine;migraine treatment;neural;Neurobiology;Neurons;Nociception;novel;novel therapeutic intervention;Outpatients;Pain;Pain Measurement;pain perception;Patients;Persistent pain;Photophobia;Phototherapy;portability;pre-clinical research;preclinical study;Property;Publishing;Rattus;Research;Research Design;response;Rest;Risk;Rodent Model;Sedation procedure;Sensory;sensory stimulus;Series;side effect;Signal Transduction;Somatosensory Cortex;Specificity;spectroscopic imaging;Spreading Cortical Depression;Stimulus;Symptoms;Testing;Therapeutic;translational study;trend;Work

PROJECT_TITLE: Narrow Band Green Light Effects on Cortical Excitability and Responsivity in Migraine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-J(02)M]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The aim of this research is to reveal the fundamental mechanisms that underlie comprehension of spoken language. An understanding of how speech is coded in the brain has significant implications for the development of new diagnostic and rehabilitative strategies for language disorders (e.g. aphasia, dyslexia, autism, et alia). Abnormal perception of phonemes is a central component to language disability in all of these conditions.

PI_NAMEs: CHANG, EDWARD  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TITLE: Functional organization of the superior temporal gyrus for speech perception

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Genetics;Mental Health;Neurosciences;Substance Misuse;Tobacco

ORG_CITY: PHILADELPHIA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative processes translating major to to identify genetic and epigenetic variation provide powerful insight into the molecular that cause addiction and other diseases of the central nervous system (CNS). However, genetic- and epigenetic-level insights into therapies that treat substance abuse remains a challenge. Here, we will exploit the chemistry of pharmacophores found in psychoactive drugs study the impact of genetic variants and epigenetic modifications in addiction. Tools Measuring changes in protein activity in mouse models of vaping addiction will identify targets for anti-addiction drugs to treat this growing epidemic.

PI_NAMEs: MATTHEWS, MEGAN L (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: activity-based protein profiling;addiction;Biochemistry;Biological Process;Brain;Central Nervous System;Central Nervous System Diseases;Chemicals;Chemistry;chromatin remodeling;Dependence;Development;Disease;DNA Sequence Alteration;Drug abuse;Drug Addiction;Electronic Nicotine Delivery Systems;enzyme activity;Enzymes;Epidemic;Epigenetic Process;epigenetic variation;Genetic;genetic variant;Genetic Variation;Goals;Image;Inhalation Exposure;insight;Maps;Measures;Mental disorders;Mixed Function Oxygenases;Modification;Molecular;Monoamine Oxidase Inhibitors;mouse model;Mutation;Nicotine Dependence;novel;novel therapeutics;Oxidases;Oxygenases;Pathology;Penetration;Pharmaceutical Preparations;pharmacologic;pharmacophore;Pharmacotherapy;Pre-Clinical Model;Process;Proteins;Proteomics;Psychotropic Drugs;Recording of previous events;Substance abuse problem;success;therapeutic development;tool;Transcriptional Regulation;Translating;vaping

PROJECT_TITLE: MAOI-inspired activity probes to translate epigenetics and genetics into drugs


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative      There is a critical need for better understanding of molecular events underlying gliomagenesis, a process leading to  most  aggressive  primary  brain  tumors.  miR- 10b  emerged  as  a  common  regulator  involved  in  neoplastic  transformation  of  glial  cells,  glioma  growth,  and  survival.  This  project  will  investigate  epigenetic  mechanisms  of  miR- 10b activation in the brain and thereby advance our understanding of brain tumors and may open the door for  new therapeutic approaches.

PI_NAMEs: KRICHEVSKY, ANNA M. (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: 3-Dimensional;Adult;Affect;aggressive therapy;Animal Model;Anti-sense RNA;Apoptosis;Architecture;Astrocytes;Binding;Biochemical;Brain;brain cell;Brain Neoplasms;CCCTC-binding factor;Cell Cycle;Cell model;Cells;ChIP-seq;Chromatin;Chromatin Loop;chromosome conformation capture;comparative;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Data;Data Analyses;data modeling;Dependence;derepression;Diagnosis;Disease;DNA;DNA analysis;DNA Methylation;Elements;Enhancers;Epigenetic Process;Etiology;Europe;Event;fetal;Gene Expression;Genes;Genetic;Genetic Transcription;genome editing;genome-wide;Genomic Segment;Genomics;Glioblastoma;Glioma;Gliomagenesis;Goals;Growth;Heterogeneity;Hi-C;Histones;Human;imaging approach;In Situ Hybridization;Investigational Therapies;Lead;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Mediating;Microglia;MicroRNAs;Modeling;Molecular;Molecular Conformation;molecular targeted therapies;Mutate;Mutation;neoplastic cell;Neoplastic Cell Transformation;Neoplastic Processes;nerve stem cell;Neuroglia;Neurons;novel;novel strategies;novel therapeutic intervention;Oncology;overexpression;Patients;Pattern;pediatric patients;Primary Brain Neoplasms;Process;promoter;Prosencephalon;Proteins;Regulation;Regulatory Element;Repression;Resolution;RNA;RNA Interference;Role;Signal Transduction;Site;stem cells;Techniques;Testing;Therapeutic;therapeutically effective;three dimensional structure;Tissues;tool;Transcript;transcription factor;Transcriptional Activation;tumor;United States;Untranslated RNA;Up-Regulation;virtual;Work

PROJECT_TITLE: Epigenetics and 3D Structure of miR-10b/HoxD Locus in the Brain and Malignant Glioma

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Cancer treatments are complex, potentially toxic, and expensive to deliver. This new training program for pre and postdoctoral trainees focuses on preparing scientists from diverse disciplines to become independent investigators to conduct cancer care delivery research that will ultimately improve the care experience for patients with cancer. With the support of their mentors, formal coursework, selected emphasis activities, and professional socialization, trainees will acquire skills in descriptive discovery research, intervention development and testing, and implementation science to address gaps in the field.

PI_NAMEs: FRIESE, CHRISTOPHER R (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: cancer care;care delivery;Interdisciplinary Study;Research Training

PROJECT_TITLE: Interdisciplinary Research Training Center in Cancer Care Delivery

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Immunotherapy of cancer using cells is an expensive and cumbersome process. The present project aims at developing artificial cells that can be produced inexpensively via microfluidic engineering based methods. These artificial cells will be developed to activate T cells in vivo to boost its capability to fight cancer.

PI_NAMEs: AGRAWAL, ANSHU ;LEE, ABRAHAM P (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Adhesions;Adjuvant;Affect;Animal Testing;Antibodies;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;APC Vaccine;Area;Autoantigens;Autologous;Back;Binding;Biological;Blood;Breast Cancer Patient;cancer immunotherapy;Cancer Patient;CD28 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Adhesion Molecules;Cell membrane;cell preparation;Cell Size;Cells;Complex;Consumption;Cytoskeleton;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;efficacy evaluation;Emulsions;Engineering;Engraftment;Evaluation;fighting;Formulation;Goals;Grant;Hydrogels;Immune system;Immunologic Memory;immunological synapse;In Vitro;in vivo;in vivo evaluation;Incubated;Individual;Influenza;Integral Membrane Protein;Integrins;Interferon Type II;Ligands;Lipid Bilayers;Malignant Breast Neoplasm;Malignant Neoplasms;manufacturing scale-up;mechanical properties;Mechanics;Melanoma;Membrane;Methods;Microfluidic Microchips;Microfluidics;Modeling;Molecular;Mus;neoplastic cell;Patients;Peripheral Blood Mononuclear Cell;Process;Production;Proliferating;Proteins;response;scale up;Specificity;Synapses;T cell response;T cell therapy;T-Cell Activation;T-Lymphocyte;Testing;Time;TNF gene;tumor;Tumor Antigens;tumor eradication;Tumor Expansion;tumor microenvironment;tumor progression;unilamellar vesicle;Vaccination

PROJECT_TITLE: Microfluidic Precision Engineered Artificial Antigen Presenting Cells for Cancer Immunotherapy


ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: The proposed center, ASPIRES, addresses a public health problem of highest importance, youth suicide. The health care system has been identified as an optimal location for suicide prevention, but lack of prevention strategies universally integrated into routine health care is an obstacle to reducing the rate of youth suicide. ASPIRES will facilitate integrated research studies of high impact, applying innovative sustainable practice- based research methods with strong potential to address national suicide prevention priorities and help to achieve the aspirational goal of rapidly reducing youth suicide in the U.S.

PI_NAMEs: BRIDGE, JEFFREY A (contact);FONTANELLA, CYNTHIA ANN

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: Acceleration;Acute;acute care;Address;Adolescent;alternative treatment;Back;brief intervention;Caring;Child;Childhood;Clinical Pathways;Common Data Element;Communication;Communities;Continuity of Patient Care;data integration;data sharing;Detection;Development;Discipline;Early identification;effective intervention;effective therapy;Effectiveness of Interventions;effectiveness testing;effectiveness/implementation design;effectiveness/implementation hybrid;Ensure;epidemiology study;Evidence based intervention;Evidence based treatment;experience;Family;Fostering;Goals;Grant;health care delivery;health care settings;health disparity;Health Services;Health Services Accessibility;Healthcare;Healthcare Systems;high risk;Hospitalization;Household;Hybrids;implementation context;implementation facilitators;implementation framework;Implementation readiness;implementation strategy;improved;Individual;Infrastructure;innovation;Inpatients;Intervention;Location;medical specialties;National Institute of Mental Health;next generation;Ohio;Patients;Pattern;Pediatric Hospitals;Persons;Pilot Projects;point of care;Population Heterogeneity;Positioning Attribute;Practice based research;Prevention;Prevention Research;Prevention strategy;preventive intervention;primary care setting;programs;Psychiatric Hospitals;Public Health;Recommendation;reducing suicide;Research;Research Methodology;Research Project Grants;research study;Risk;routine practice;Running;Schools;Science;screening;Service setting;socioeconomics;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;synergism;Target Populations;technology intervention;Testing;Translations;Underserved Population;United States;uptake;Vision;Work;Youth

PROJECT_TITLE: The Center for Accelerating Suicide Prevention in Real-world Settings (ASPIRES)


NIH_SPENDING_CATS: Clinical Research;Health Services;Mental Health;Prevention;Suicide;Suicide Prevention

PHR: The Administrative Core (AC) is crucial to the success of ASPIRES, its projects, and cores. The center would not be able to function efficiently and effectively without the services of the AC. The AC, in collaboration with the MC, will assure that the overarching goal of the center is carried throughout each project and core.

PI_NAMEs: BRIDGE, JEFFREY A (contact)

PROJECT_TERMS: Acceleration;Address;Administrator;Annual Reports;Applications Grants;Books;career;Clinical;clinical practice;Clinical Trials Data Monitoring Committees;Collaborations;Collection;Committee Members;Communication;Community Practice;community setting;Continuity of Patient Care;Data;Data Set;Decision Making;Development;Discipline;Engineering;Ensure;Evaluation;Feasibility Studies;Feedback;Fostering;Funding;Future;Goals;Grant;implementation research;improved;Information Systems;Infrastructure;innovation;International;Joints;Journals;Lived experience;member;Methodological Studies;Methodology;Methods;Monitor;novel;organizational structure;Outcome;Persons;Pilot Projects;Policy Maker;practice setting;Prevention approach;prevention practice;Prevention Research;prevention service;Prevention Services Research;preventive intervention;Principal Investigator;Productivity;programs;Provider;Public Health;Published Comment;Publishing;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;research study;Resource Allocation;Safety;Science;Scientist;Services;social media;success;Suicide;Suicide prevention;Sum;symposium;synergism;timeline;tool;Training;training opportunity;web site;Work;Workplace;Youth

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: Narrative Our results point to mature neutrophils recruited to the tumor microenvironment suppressing the expansion and activation of T cells required for anti-tumor immunity. This suppressor activity was dependent on a number of neutrophil functions, including complement signaling, a therapeutically targetable pathway. The impact of our proposal is to gain safety and preliminary efficacy data on APL-2-based regimens in recurrent epithelial ovarian cancer with malignant effusions and a detailed understanding of how these regimens modulate the immune landscape in the tumor microenvironment.

PI_NAMEs: SEGAL, BRAHM H.;ZSIROS, EMESE  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Anaphylatoxins;anti-PD-1;arm;Ascites;bevacizumab;Biology;Blood;Blood Vessels;cancer immunotherapy;Cancer Patient;Cause of Death;cell injury;chemokine;Chemotactic Factors;Circulation;cohort;Complement;Complement 3a;Complement 5a;Complement component C4a;Cyclophosphamide;cytokine;Cytometry;Cytotoxic T-Lymphocytes;Data;Diagnosis;Disease;disorder control;Disseminated Malignant Neoplasm;efficacy evaluation;efficacy testing;effusion;Epithelial ovarian cancer;Exposure to;FDA approved;Foundations;FRAP1 gene;Genetic Transcription;glucose uptake;Goals;granulocyte;Granulopoiesis;Guidelines;Human;Immune checkpoint inhibitor;Immune response;immunogenic;immunoregulation;Immunosuppression;Immunotherapy;Infiltration;Inflammatory;inhibitor;Lead;Liquid substance;Lymphocyte;Malignant - descriptor;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Memory;Mitochondria;Modeling;Morphology;Mus;Myeloid-derived suppressor cells;NADPH Oxidase;National Comprehensive Cancer Network;neutrophil;Neutrophil Infiltration;Newly Diagnosed;novel;novel strategies;nuclear factors of activated T-cells;objective response rate;Oral;paroxysmal nocturnal hemoglobinuria;Pathway interactions;Patients;pembrolizumab;Peptides;Phase II Clinical Trials;phase II trial;Phenotype;primary endpoint;Progression-Free Survivals;Proliferating;Quality of life;Randomized;randomized trial;Recurrence;Refractory;Regimen;Relapse;Research;response;Response Generalization;response to injury;Safety;Sampling;secondary endpoint;Signal Pathway;Signal Transduction;Specific qualifier value;standard of care;Suppressor-Effector T-Lymphocytes;survival prediction;T cell infiltration;T memory cell;T-Cell Activation;T-Lymphocyte;Testing;Therapeutically Targetable;Time;tumor;Tumor Immunity;tumor microenvironment;tumor progression;United States;Work

PROJECT_TITLE: Targeting complement to enhance antitumor immunity and control malignant effusions in patients with recurrent epithelial ovarian cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Childhood Injury;Clinical Research;Dissemination and Implementation Research;Health Services;Mental Health;Pediatric;Prevention;Social Determinants of Health;Suicide;Suicide Prevention

PHR: NARRATIVE The ASPIRES Center will implement, evaluate, and optimize suicide prevention interventions and practices across the continuum of primary, specialty, and acute care to improve youth mental health and reduce the suicide rate. The Methods Core (MC) is essential to that process in promoting the advancement and application of rigorous and innovative methods to test and evaluate the impact and implementation of these evidence-based interventions. The overall goal of the MC is to strengthen the rigor, quality, and implementation success of the research projects within ASPIRES while simultaneously developing and promoting innovative methods for suicide prevention research.

PI_NAMEs: BROCK, GUY  (contact)

PROJECT_TERMS: Acceleration;acute care;Address;Applications Grants;Area;Artificial Intelligence;Behavior;Behavior Therapy;Big Data Methods;Capital;career;Childhood;clinical decision-making;Collaborations;Communities;Community Health;Creativeness;Data;Data Analyses;Data Collection;Data Element;data harmonization;data management;data sharing;data standards;design;Development;digital health;Elements;Ensure;Environment;Evaluation;Evidence based intervention;Fostering;Future;Generations;Goals;Grant;Growth and Development function;Health;health management;Health system;Healthcare Systems;implementation framework;implementation science;implementation strategy;improved;Information Technology;Infrastructure;innovation;Institution;interdisciplinary collaboration;Intervention;Leadership;medical specialties;Mental Health;Mentors;Methodology;Methods;Modeling;Monitor;multidisciplinary;National Institute of Mental Health;Nerve;novel;Ohio;outreach;Parents;Patient Representative;Patients;Pediatric Hospitals;Pilot Projects;Population;population health;Population Intervention;Population Study;Positioning Attribute;Practical Robust Implementation and Sustainability Model;Predictive Analytics;Preparation;Prevention;prevention practice;Prevention Research;preventive intervention;Process;Productivity;programs;Protocols documentation;Public Health;public health intervention;Qualitative Methods;Quality Control;reducing suicide;Research;Research Design;Research Institute;Research Methodology;Research Personnel;Research Project Grants;Resources;Risk;Science;Services;social health determinants;social structure;Standardization;Statistical Models;student training;success;Suicide;Suicide prevention;suicide rate;synergism;Technology;Testing;Universities;Work;working group;Youth

PROJECT_TITLE: Methods Core


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Data Science;Dental, Oral, and Craniofacial Disease;Pediatric;Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The DS-CHANGE training program builds upon long-standing collaborations between Kwame Nkrumah University of Science and Technology (KNUST), the University of Washington (UW), Seattle Children’s Hospital, and the non-profit Smile Train. We propose to (i), develop a cadre of trained Ghanaian scientists who can use data science approaches to tackle prominent child health problems, (ii) build faculty and institutional capacity for data science at KNUST, and (iii) develop competencies to ensure Ghanaian biomedical data science teams work effectively and synergistically. Trainees will develop skills and acquire experience with real world data science problems that address 3 of the top 10 ten causes of child death and disability in Ghana: malaria, injury and congenital malformations.

PI_NAMEs: AMOAKO-YIRENKYI, PETER ;DONKOR, PETER ;MCKINNEY, CHRISTY MICHELLE (contact)

PROGRAM_OFFICER_NAME: POVLICH, LAURA

PROJECT_TERMS: Active Learning;biomedical data science;Biometry;certificate program;Cessation of life;Child;Child Health;Clinical Informatics;Collaborations;Complex;computer science;Congenital Abnormality;congenital anomaly;Data Science;Data Scientist;disability;Discipline;Doctor of Philosophy;Educational process of instructing;Effectiveness;Epidemiology;evidence base;externship;Faculty;Funding;Ghana;Goals;graduate student;Health;Injury;Institution;institutional capacity;Malaria;Mathematics;Mentors;Methodology;Methods;orofacial cleft;Parasitology;Pediatric Hospitals;Pediatrics;Positioning Attribute;programs;Qualifying;Research;Research Institute;Science;Scientist;Smiling;Technology;Training;Training Programs;Universities;Washington

PROJECT_TITLE: Data Science for Child Health Now in Ghana (DS-CHANGE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(70)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: BALTIMORE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Many researchers use DNA sequencing to study disease and biology, and analyzing this data requires sophisticated software capable of piecing together puzzles made of billions of fragments of DNA. The main strategy used to assemble the puzzle — aligning sequencing reads to a genome — suffers from “reference bias” which causes it to give incorrect answers downstream. Here we propose a suite of new methods, visualizations, software tools, and genome representations that help researchers to analyze sequencing data while avoiding the perils of reference bias. ii

PI_NAMEs: LANGMEAD, BENJAMIN THOMAS (contact)

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TERMS: Address;Alleles;Awareness;Biology;Categories;Collection;Communities;Complementarity Determining Regions;Computer software;Darkness;Data;Data Set;Disease;DNA;DNA sequencing;Event;experimental study;Genetic;genetic information;Genetic Variation;Genome;Genomics;Genotype;Glean;Graph;Haplotypes;Human;Human Genome;improved;indexing;Libraries;Licensing;Linkage Disequilibrium;Maps;Measures;Methods;model organism;Modernization;next generation sequencing;novel;open source;preservation;Process;Property;Publishing;reference genome;Research;Research Personnel;Resources;Sequence Alignment;Site;Software Tools;Standardization;System;Text;tool;Training;uptake;Variant;Visualization;Work

PROJECT_TITLE: Personal and panel references for improved alignment

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

PHR: Project narrative: Pediatric primary care is an ideal service setting for intervention research designed to rapidly reduce suicide and suicidal behaviors among US youth. This stepped wedge cluster- randomized controlled trial will test effectiveness of a population-based quality improvement (QI) intervention, Stepped Approach to Reducing Suicide in Primary Care (STARRS-PC) that implements a clinical pathway for youth identified by screening as being at elevated risk for suicide.

PI_NAMEs: FONTANELLA, CYNTHIA ANN (contact)

PROJECT_TERMS: Academy;Acceleration;Accident and Emergency department;Address;Adolescent;aged;American;Caring;Cause of Death;Cessation of life;Childhood;Clinical;clinical care;Clinical Pathways;Clinical Trials;Communities;Community Practice;design;Detection;effectiveness evaluation;Effectiveness of Interventions;effectiveness research;effectiveness testing;effectiveness/implementation hybrid;effectiveness/implementation study;evidence base;Evidence based intervention;Family;Feeling suicidal;follow-up;Health Personnel;Health Professional;Healthy People 2020;high risk population;Hybrids;implementation facilitators;improved;Individual;Intervention;intervention effect;Intervention Studies;Interview;Knowledge;Low income;Managed Care;Mediating;Mediator;Mental Health;Modeling;Morbidity - disease rate;National Institute of Mental Health;non-suicidal self injury;Ohio;organizational readiness;Outcome;Outcome Assessment;Outcome Measure;Pathway interactions;Patient-Focused Outcomes;Patients;pediatrician;Pediatrics;Phase;Pilot Projects;population based;practice setting;Prevention strategy;preventive intervention;Primary Care;primary care clinician;primary care setting;Process;Protocols documentation;Provider;Public Health;Randomized, Controlled Trials;recruit;reducing suicide;Reporting;Research;Research Design;Risk;Risk Assessment;Risk Management;Risk Reduction;routine care;rural setting;Safety;satisfaction;screening;secondary outcome;Self Efficacy;Service setting;Site;Strategic Planning;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Surveys;Testing;therapy design;Time;Time trend;treatment as usual;treatment effect;Triage;urban setting;Youth

PROJECT_TITLE: Signature Project


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Mental Health;Mental Illness;Pediatric;Prevention;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

PHR: Project Narrative With this proposal we seek to prevent an imminent public health concern, suicidal behavior (SB), among exceedingly vulnerable 6- to 9-year-old children whose parents have a history of suicide attempt (PH+). Through both genetic and familial mechanisms, these children are at especially high risk of NSSI and SB including suicide attempts, however, no prevention programs exist for young children in PH+ families. We will use an established prevention program to address family-and child-level mediators of SB and NSSI and evaluate parental and clinician acceptability, feasibility, and effectiveness on reducing suicide risk factors in highly vulnerable youth.

PI_NAMEs: SHEFTALL, ARIELLE HOPE (contact)

PROJECT_TERMS: 11 year old;18 year old;9 year old;Acceleration;acceptability and feasibility;Address;Adult;Age;Age of Onset;Awareness;Behavior;behavior observation;Behavior Therapy;boys;Buffers;Cause of Death;Child;Child Behavior;Child of Impaired Parents;Child Rearing;Childhood;Clinic;cohesion;Communication impairment;coping mechanism;depressive symptoms;Diagnostic;Discipline;early onset;Educational process of instructing;effective intervention;Effectiveness;effectiveness testing;effectiveness/implementation hybrid;efficacious intervention;Emergency department visit;emotion dysregulation;emotion regulation;Emotional;Emotions;Empathy;Environment;externalizing behavior;Family;Feeling suicidal;follow-up;Future;Genetic;girls;Goals;Heritability;high risk;high risk population;Hostility;implementation framework;improved;Intervention;intervention effect;Interview;maltreatment;Measures;Mediator;Methods;model design;Monitor;National Institute of Mental Health;non-suicidal self injury;offspring;Outcome;parent-child communication;parental monitoring;parenting intervention;Parents;Participant;Patient Self-Report;peer;Perception;permissiveness;Physiological;Population;post intervention;Practical Robust Implementation and Sustainability Model;prevent;Prevention program;primary outcome;programs;Public Health;Qualitative Methods;Race;Randomized;Recording of previous events;reducing suicide;Reporting;Research;Research Priority;resilience;Risk;Risk Assessment;Risk Factors;Risk Reduction;Schools;secondary outcome;Self-Injurious Behavior;Services;skills;social skills;statistics;Stressful Event;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Testing;Time;Training Programs;transmission process;treatment as usual;trend;virtual;Visit;Vulnerable Populations;Youth

PROJECT_TITLE: Incredible Years - Parent Training


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Firearms Research;Health Services;Mental Health;Mental Illness;Patient Safety;Pediatric;Prevention;Serious Mental Illness;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

PHR: The suicide rate in U.S. adolescents has increased 75% during the past decade, but scientifically supported interventions do not exist to prevent adolescent suicide during high-risk healthcare transition periods. To address this gap, we will develop and test a safe firearm storage suicide prevention intervention (Safer Still) that has considerable capacity for future widespread use. Successful completion of this study will contribute to the NIH’s mission to support evaluation of innovative interventions to prevent firearm injury and mortality, which will have direct community benefits.

PROJECT_TERMS: 17 year old;Acceleration;Address;Adolescent;adolescent suicide;aged;Behavior;behavioral economics;behavioral health;Caring;Cause of Death;Cessation of life;Childhood;Choice Behavior;Communities;cost;critical period;Data;Decision Making;Development;Economics;Effectiveness;effectiveness testing;effectiveness/implementation study;Evaluation;Family;Feedback;firearm storage;Firearms;Future;General Population;Goals;Gun injury;Health;Health Personnel;Health Services;Healthcare;Healthcare Systems;high risk;Hospitals;Household;Hybrids;implementation evaluation;improved;Individual;informant;Information Technology;innovation;inpatient psychiatric treatment;Inpatients;insight;interest;Intervention;intervention effect;Intervention Studies;Interview;Length of Stay;Marketing;Mediating;Mediator;Mental Health;Mission;Modeling;Modification;mortality;Motivation;Ownership;Parents;Participant;Patients;Persons;Phase;Practical Robust Implementation and Sustainability Model;prevent;Prevention Research;preventive intervention;Psychiatric Hospitals;psychiatric inpatient;Psychology;Randomized;Randomized, Controlled Trials;Readiness;Recording of previous events;recruit;Reporting;Research;response;Risk;routine care;Sampling;Self Management;Series;service intervention;suicidal adolescent;suicidal behavior;suicidal morbidity;suicidal patient;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Technology;technology intervention;Testing;therapy development;tool;traditional care;treatment as usual;United States;United States National Institutes of Health;Update;usability;Youth

PROJECT_TITLE: Safer Still


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Glioblastoma is the most common and lethal brain cancer, and one key mechanism by which it develops resistance to chemotherapy involves defects in a DNA repair pathway called mismatch repair (MMR). There are currently no treatments proven to be effective against these especially aggressive MMR-deficient glioblastomas. The work of this proposal investigates two new therapeutic strategies against these cancers: 1) combining inhibitors of different calcium channels, and 2) repurposing the chemotherapy drug irinotecan and the anti- cholesterol statin drugs as novel inhibitors of the TGF-β signaling pathway.

PI_NAMEs: PUROW, BENJAMIN W. (contact)

PROJECT_TERMS: ABCB1 gene;Adult;Affect;Anti-Hypertensive Agents;anti-PD-1;bevacizumab;Biological;Brain;Brain Neoplasms;Calcium;Calcium Channel;Calcium Channel Blockers;Calcium Channel Inhibition;Cell Death;Cell Survival;checkpoint therapy;Chelating Agents;chemotherapy;Childhood;Cholesterol;Clinic;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Colon;Computer Models;Defect;Development;Devices;DNA;DNA Damage;DNA Repair Pathway;efficacy evaluation;Excision;experience;gene repair;Genes;Glioblastoma;Hereditary Nonpolyposis Colorectal Neoplasms;Hypertension;Immune checkpoint inhibitor;Immune response;Immunocompetent;Immunologics;Immunotherapeutic agent;In Vitro;in vivo;inhibitor;insight;irinotecan;knock-down;Knock-out;L-Type Calcium Channels;Least-Squares Analysis;MADH3 gene;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;Mediator;Mibefradil;Mismatch Repair;Mismatch Repair Deficiency;MLH1 gene;Modeling;mouse model;MSH2 gene;MSH6 gene;Mus;Mutate;Mutation;novel;novel therapeutic intervention;orotate;Oxidative Stress;Patients;pediatric patients;Pharmaceutical Preparations;Phenotype;phosphoproteomics;PMS2 gene;pre-clinical;Radiation;Recurrence;Reporting;Resistance;Resistance development;resistance mechanism;response;Safety;Secondary to;Signal Transduction;Simvastatin;small hairpin RNA;Small Interfering RNA;standard care;stem;T-Type Calcium Channels;temozolomide;Testing;TGF Beta Signaling Pathway;Therapeutic;Time;tool;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;treatment strategy;tumor;Verapamil;voltage;Work

PROJECT_TITLE: Vulnerabilities of MMR-deficient glioblastoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Patient Safety;Pediatric;Prevention;Serious Mental Illness;Suicide;Suicide Prevention

PHR: Suicide rates for U.S. adolescents are at the highest levels in over a decade, while access to psychiatric hospitalization to treat youth at acute risk is decreasing, despite the increasing demand for this higher level of care. To address the need for additional treatment options, we will examine a brief, evidence-based alternative to inpatient psychiatric care (Intensive Crisis Intervention, ICI) that has the potential for widespread community use. This research is consistent with NIMH’s priorities for high-impact practice-based research with near-term potential to address NIMH suicide prevention priorities.

PI_NAMEs: FRISTAD, MARY A (contact)

PROJECT_TERMS: Acceleration;acceptability and feasibility;Accident and Emergency department;Acute;Address;Adherence;Admission activity;Adolescent;Age;alternative treatment;Ambulatory Care;base;Beds;Behavioral;behavioral health;Caring;Case Series;Catchment Area;Cause of Death;Child;Childhood;Clinical;Clinical Management;clinical material;Cognitive;Cognitive Therapy;Communities;Consumer Satisfaction;Crisis Intervention;Data Collection;Effectiveness;effectiveness evaluation;Eligibility Determination;Enrollment;Evaluation;evidence base;Evidence based treatment;experience;Family;Family psychotherapy;Feeling hopeless;Feeling suicidal;follow-up;functional improvement;Goals;Health Services Accessibility;high risk;hospital readmission;Hospitalization;hybrid type 1 design;implementation facilitators;implementation intervention;improved;innovation;inpatient psychiatric treatment;inpatient service;Inpatients;Intervention;intervention refinement;Interview;intrinsic motivation;Knowledge;Length of Stay;Manuals;Measures;Mental disorders;Methods;Modeling;motivational enhancement therapy;National Institute of Mental Health;novel;novel strategies;Outcome;Outcome Assessment;parenting intervention;Parents;Patients;Pediatric Hospitals;pilot test;pilot trial;Practical Robust Implementation and Sustainability Model;Practice based research;primary outcome;Procedures;Process;Protocols documentation;Provider;Psychiatric Hospitals;psychiatric inpatient;Psychiatric therapeutic procedure;Randomized;Randomized, Controlled Trials;readmission rates;Recommendation;recruit;reducing suicide;Research;response;Risk;Safety;secondary outcome;Secure;Self-Injurious Behavior;Services;skills;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Supervision;Surveys;Symptoms;Testing;Therapeutic;Time;Training;treatment effect;Treatment outcome;trial comparing;Work;Youth

PROJECT_TITLE: Intensive Crisis Intervention


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Digestive Diseases;Mental Health;Microbiome;Neurosciences;Nutrition;Pediatric

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: The proposed research is relevant to public health because it focuses on identifying the role of the microbiome-gut-brain axis in the pathogenesis of child-onset anxiety at the mechanistic level of microbe-epithelial interactions and enteroneuroactivity. Once these interactions are fully described, there is the potential for a significant advancement in the mental and overall health of children with anxiety and neurodevelopmental disabilities by deepening our understanding of the necessity of microbes in early life neurobehavioral development. Thus, the project is relevant to NICHD’s mission because it pertains to enhancing the lives of children and understanding child development.

PI_NAMEs: BOLTE, ERIN E (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: 3 year old;Adolescent;Anabolism;Animals;Anxiety;anxiety-like behavior;behavior test;behavioral phenotyping;Brain;Career Choice;Cell Count;cell type;Cells;Child;Child Development;Child Health;Childhood;childhood anxiety;college;Colon;Complex;Consumption;Data;Development;Developmental Process;dietary control;Dopamine;dysbiosis;Enteral;Enteroendocrine Cell;Environment;Enzymes;Epithelium;Exposure to;Feces;feeding;functional status;Funding;GABA Receptor;gamma-Aminobutyric Acid;Gastroenterology;gastrointestinal epithelium;Germ-Free;Goals;gut microbes;gut microbiome;gut-brain axis;High Fat Diet;host-microbe interactions;immunoreactivity;Impairment;In Vitro;in vivo;intestinal epithelium;Intestines;Investigation;Knowledge;Laboratories;Lactation;Lead;Life;Link;maternal obesity;Measures;Medicine;metabolic phenotype;metabolomics;Microbe;Microbiology;microbiome;Mission;Modeling;Modification;multidisciplinary;National Institute of Child Health and Human Development;neurobehavior;neurobehavioral;neurochemistry;neurodevelopment;Neurodevelopmental Disability;Neurologic;Neurology;Neurotransmitters;nonhuman primate;offspring;Pathogenesis;Pathway interactions;pediatrician scientist;Phenotype;Pregnancy;Primates;Process;Production;Psyche structure;Public Health;receptor;Research;response;reward circuitry;Rodent;Rodent Model;Role;Secondary to;Serotonin;Shapes;stool sample;Testing;Texas;Tryptophan 5-monooxygenase;United States National Institutes of Health;Weaning

PROJECT_TITLE: The role of microbe-epithelial interactions on primate enteroneuroactivity in response to maternal high fat diet

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-V(20)L]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: The purpose of this research proposal is to study the role of chromatin dynamics in genome regulation and cell fate decisions. The proposed research is relevant to public health because many of the proteins studied are mutated in human cancers, including pancreatic neuroendocrine tumors and pediatric glioblastomas. Understanding the normal physiology of these proteins will lead to greater insights and therapeutic opportunities in disease states.

PI_NAMEs: BANASZYNSKI, LAURA  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Adult;adult stem cell;Cell Maintenance;Cell Physiology;cell type;Cells;Childhood Glioblastoma;Chromatin;chromatin modification;Chromatin Structure;Complex;Data;Deposition;Development;developmental disease;Disease;DNA;epigenetic regulation;Equilibrium;Euchromatin;Eukaryotic Cell;Event;Gene Activation;genetic corepressor;Genome;Genomics;Goals;Heterochromatin;histone acetyltransferase;Histones;Homeostasis;Human;insight;Islet Cell Tumor;Malignant Neoplasms;Mediating;Molecular;Molecular Chaperones;mouse model;Mutate;Mutation;novel;Organism;Phosphorylation;Physiology;Proteins;Public Health;recruit;Regulation;Research;Research Proposals;Role;Serine;Specific qualifier value;Structure;Therapeutic;Variant

PROJECT_TITLE: Chromatin Dynamics and Genome Regulation

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ORG_CITY: BOSTON

ORG_STATE: MA

PHR: Narrative This pulmonary training program in basic science and clinical/translational research provides comprehensive training for individuals with a serious commitment to a career in biomedical research focused on lung disease and critical care medicine. Our primary goals are to train the next generation of physician-scientists and scientists to become independent researchers in academic medicine, better understand the pathogenesis of lung disease and identify new therapeutic modalities for lung disease.

PI_NAMEs: LEVY, BRUCE D;WASHKO, GEORGE R (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Research;respiratory;Training

PROJECT_TITLE: Integrated Training in Respiratory Research

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]