NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

PHR: PROJECT NARRATIVE Alzheimer's disease (AD) is the most common neurodegenerative disease that causes dementia. Neuroinflammation, mediated by microglia, is a key disease mechanism of AD that needs to be better understood at the molecular level although existing methodological barriers limit our ability to characterize protein changes occurring in microglia in AD. In this proposal, we will use a novel cell type-specific in-vivo proteomic labeling approach called ciBONCAT to investigate the proteomic characteristics of microglia-mediated disease mechanisms in the brain and cerebrospinal fluid using mouse models of AD pathology, which may ultimately lead to identifying novel treatment targets and biomarkers for AD.

PI_NAMEs: RANGARAJU, SRIKANT  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: abeta accumulation;Adult;Age;age related;Aging;Alkynes;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amino Acids;Amyloid beta-Protein;analog;Animals;Anti-Inflammatory Agents;Apolipoprotein E;apolipoprotein E-4;APP-PS1;Astrocytes;Autopsy;Azides;beta amyloid pathology;Bioinformatics;Biological Markers;Biological Process;Biology;biomarker discovery;Brain;brain cell;Breeding;Cell Separation;cell type;Cells;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Characteristics;Chemistry;Coupled;Dementia;Dependence;Disease;Disease associated microglia;Genetic;Genetic Risk;genetic risk factor;Human;Human Genetics;Immune;immune checkpoint;Immunologic Markers;immunoregulation;Impaired cognition;in vivo;inducible Cre;Inflammasome;Inflammation;Inflammatory;inhibitor;innovation;insight;Intervention;Knock-in Mouse;Knowledge;Label;Late Onset Alzheimer Disease;Lipopolysaccharides;LoxP-flanked allele;Mass Spectrum Analysis;Mediating;Messenger RNA;Methionine;Methionine-tRNA Ligase;Methodology;Methods;Microglia;Modeling;Molecular;Morphologic artifacts;mouse model;Mouse Protein;multidisciplinary;Mus;mutant;Nerve Degeneration;Neurodegenerative Disorders;Neuroimmunomodulation;neuroinflammation;Neurons;novel;novel marker;novel strategies;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathologic;Pathology;Phenotype;Positioning Attribute;protein aggregation;protein biomarkers;Protein Biosynthesis;Proteins;Proteome;proteomic signature;Proteomics;Resolution;Risk;Role;Sampling;Sampling Biases;selective expression;Shapes;specific biomarkers;Synapses;Systems Biology;Tamoxifen;Testing;Transcript;transcriptomics;transgenic model of alzheimer disease;Wild Type Mouse

PROJECT_TITLE: Microglia-specific proteomic mechanisms and biomarkers of neuroinflammation in Alzheimer’s disease


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: ITHACA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative There is no treatment to correct the reduced brain blood flow observed in Alzheimer disease patients, although this reduction likely contributes to cognitive deficits and may accelerate disease progression. We recently found that blood flow in individual brain capillaries is stalled by arrested white blood cells in mouse models of Alzheimer’s disease, and we now propose to investigate the molecular and cellular mechanisms causing these capillary stalls and to determine the impact of increasing brain blood flow by interfering with capillary stalling on the progression of disease. These capillary stalls are a potential mechanism for the decreased blood flow in AD, and this work could lead to novel therapies that improve cognitive function and slow Alzheimer’s disease progression.

PI_NAMEs: NISHIMURA, NOZOMI ;SCHAFFER, CHRIS B (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: abeta accumulation;abeta deposition;Abeta synthesis;Acceleration;adhesion receptor;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Amyloid deposition;animal old age;Antibodies;arteriole;Award;Basement membrane;Binding;Blood capillaries;Blood flow;Blood Vessels;Brain;Brain Pathology;Brain region;CD36 gene;Cell Adhesion Molecules;cell injury;cell type;Cells;cerebral capillary;Cerebrovascular Circulation;Chronic;Cognitive;Cognitive deficits;cognitive function;Complement;constriction;Data;Development;Disease Progression;Endothelial Cells;Endothelium;Enzymes;Exhibits;Exposure to;Feedback;Fluorescence;Fluorescence Microscopy;Functional disorder;Hippocampus;Hour;Human Amyloid Precursor Protein;hypoperfusion;Hypoxia;Image;improved;in vivo;in vivo imaging;Incidence;Individual;Inflammation;Inflammatory;Knock-in;Knock-in Mouse;Knock-out;knockout gene;Leukocytes;Link;Location;Macrophage;Membrane Proteins;Memory;Microscopy;Molecular;mouse model;Mus;mutant;NADP;Nerve Degeneration;Neurobehavioral Manifestations;neuropathology;neutrophil;new therapeutic target;novel;novel therapeutics;overexpression;Oxidases;Pathology;Penetration;Performance;Pericytes;Peroxonitrite;pharmacologic;Photons;Physiological;presenilin;prevent;Production;promoter;protein expression;Reactive Oxygen Species;Role;scavenger receptor;Severities;Short-Term Memory;Signal Transduction;Site;Source;Speed;Surface;Symptoms;Testing;Therapeutic;therapeutic target;Time;two-photon;VEGFA gene;venule;Work

PROJECT_TITLE: Stalled capillary flow: a novel mechanism for hypoperfusion in Alzheimer disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Patient Safety;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE Although many patients have benefited from existing medications for alcohol use disorder (AUD), their effects are moderate or not effective in some individuals. Future efforts in the development of medications for AUD need to include: establishing new targets for drug development; using validated animal models to test medications for AUD; and developing biomarkers to help predict drug response. In addition, if possible, it is important to utilize medications that are familiar within the clinical practitioner community which will facilitate the inclusion of these medications into the alcohol treatment process.

PI_NAMEs: HAASS-KOFFLER, CAROLINA LUISA (contact)

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: Absence of pain sensation;absorption;acceptability and feasibility;Acute;addiction;Adverse event;adverse event risk;Agitation;alcohol abuse therapy;Alcohol consumption;alcohol content;alcohol craving;alcohol effect;alcohol intervention;alcohol use disorder;Alcohols;Animal Model;behavioral response;Binding;biobehavior;Biological Markers;Blood;Blood - brain barrier anatomy;Brain;brain cell;Bypass;Cellular Metabolic Process;Central Nervous System;Clinical;Clinical Protocols;Clinical Trials;Cognitive deficits;Communities;Computers;Consumption;craving;cue reactivity;Cues;Data;Decision Making;design;Development;Dose;Double-Blind Method;Drug Delivery Systems;drug development;Drug Interactions;Drug Kinetics;drug repurposing;drug response prediction;Drug Targeting;efficacy evaluation;endophenotype;Energy Metabolism;Event;evidence base;Face;Female;Fentanyl;Future;Glucose;glucose metabolism;Goals;Hormones;Human;Hypoglycemia;improved;Impulsivity;Individual;Insulin;Insulin Receptor;Intervention;Intranasal Administration;Ketamine;Laboratories;Laboratory Study;Measures;medication administration;Memory;Mental Depression;Metabolism;Methods;Midazolam;Modality;Molecular Target;Monitor;monoamine;Naloxone;Neurobiology;Neurodegenerative Disorders;new therapeutic target;novel;Opioid;Output;Participant;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase;Physiological;Placebo Control;Placebos;Procedures;Process;prolonged abstinence;psychologic;Questionnaires;Randomized;Randomized, Controlled Trials;Recovery;Research;response;Role;Safety;safety assessment;safety testing;Saline;Saliva;Seizures;Stress;System;targeted treatment;Testing;Therapeutic;transmission process;Treatment outcome;Weight;Work

PROJECT_TITLE: Intranasal Insulin Administration as Medication for Alcohol Use Disorder

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Millions of years ago, retroviruses infected ancient human ancestors and became a normal part of our genome as Human Endogenous Retroviruses (HERVs). Although HERVs are generally suppressed in normal cells, HML-2 is a special HERV species transiently activated in normal embryonic cells that are destined to produce gametes as well as various adult-onset cancers, possibly contributing to formation of malignant cells. Taking advantage of the latest advancement in modeling human embryos in cell cultures using cells not derived from real human embryos, this project attempts to test the hypothesis that exposure of human embryos to environmental toxic chemicals may cause incomplete suppression of HML-2 after their transient activation in the gamete-producing cells and consequently increase the cancer risk in the next generation.

PI_NAMEs: SHIODA, TOSHIHIRO  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Adult;Affect;ATAC-seq;Benzo(a)pyrene;cancer cell;cancer predisposition;cancer risk;cancer type;carcinogenesis;Cell Culture Techniques;Cell Differentiation process;Cells;Chemicals;Computer Analysis;CRISPR-mediated transcriptional activation;Data;Databases;deep sequencing;demethylation;Development;Dieldrin;Disease;DNA;DNA Methylation;DNA Methyltransferase Inhibitor;Dose;Embryo;embryo cell;Endogenous Retroviruses;environment related cancer;environmental chemical;epigenetic marker;Epigenetic Process;epigenetic silencing;exposed human population;Exposure to;Generations;Genes;Genetic Transcription;Genome;genome-wide;Genomic DNA;Germ Cells;Goals;Heritability;Heterochromatin;Heterogeneity;high risk population;Human;Human Genome;human model;human pluripotent stem cell;humanized mouse;Impairment;in utero;in vitro Model;Individual;induced pluripotent stem cell;Infection;insight;Knock-in;Life;Link;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Mammals;Melanoma;Methyltransferase;mouse genome;mouse model;multiple omics;Mus;Mutation;next generation;Normal Cell;novel;Oncogenic;Open Reading Frames;Organoids;Outcome;perfluorooctanoic acid;pharmacologic;Play;pluripotency;Pluripotent Stem Cells;Poison;Pregnancy;Pregnant Women;prevent;Production;protein complex;reconstitution;Relaxation;repaired;Research;Retroviridae;Risk;RNA;sex;single-cell RNA sequencing;Somatic Cell;Structure of primordial sex cell;Testing;Testis;Time;Toxic Environmental Substances;toxicant;Toxicology;Transactivation;transcription factor;Transcriptional Activation;transcriptome sequencing;Viral Proteins

PROJECT_TITLE: Environmental chemicals impair epigenetic suppression of the endogenous retrovirus HML-2 in human primordial germ cells, predisposing the next generation to malignancies through HML-2 reactivation

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: NARRATIVE Increasing evidence links a range of disorders, from congenital malformations to autism, intellectual disability, and brain tumors, to mutations that cause genes to be erroneously activated. Called gain-of-function mutations, such alterations often affect regions of our genomes called enhancers—“switches” for gene activity. The proposed research will use limb development as a model to determine the molecular mechanism by which these gain-of-function enhancer mutations promote limb congenital malformations utilizing novel genetically engineered mice and cutting-edge genomics and imaging methods. .

PI_NAMEs: KVON, EVGENY  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: 3-Dimensional;Address;adverse outcome;Affect;Animal Model;Anterior;autism spectrum disorder;Back;Base Pairing;Binding;Biological Assay;Brain Neoplasms;Cell Culture Techniques;cell type;Cells;Chromatin;clinical predictors;clinically significant;Congenital Abnormality;Congenital Limb Deformities;Data;derepression;Development;developmental disease;Developmental Gene;Disease;disease model;DNA Sequence;Ectopic Expression;Embryo;Enhancers;Ensure;Epigenetic Process;epigenome;epigenomic profiling;epigenomics;Etiology;Exhibits;experimental study;Feeds;fitness;gain of function;gain of function mutation;Gene Activation;Gene Expression;Genes;Genetic;genetic regulatory protein;Genetic Transcription;Genetically Engineered Mouse;Genome;genome sequencing;Genomics;Histones;Human;imaging modality;In Vitro;in vivo;Individual;Intellectual functioning disability;Knock-in Mouse;Knowledge;Label;Lead;LHX2 gene;Limb Bud;Limb Development;Limb structure;Link;malformation;Maps;Measures;Mediator;Modeling;Molecular;mouse model;Mus;Mutagenesis;Mutation;nanometer resolution;Neurodevelopmental Disorder;novel;Nucleic Acid Regulatory Sequences;Organoids;Pathogenicity;Patients;Phenotype;Play;Polydactyly;Population;Positioning Attribute;Predisposition;rare variant;Recurrence;Reporting;Reproducibility;Research;Resolution;Role;SHH gene;Site;smoothened signaling pathway;spatiotemporal;Susceptibility Gene;Switch Genes;Testing;transcription factor;Transcriptional Regulation;transcriptome sequencing;transcriptomic profiling;Transgenic Animals;Transgenic Mice;Transgenic Organisms;ultra high resolution;Untranslated RNA;Variant;Visualization;whole genome

PROJECT_TITLE: Decoding the Mechanism of Pathogenic Enhancer Mutations In Congenital Limb Disorders

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Alzheimer’s Disease (AD) is a devastating disease affecting over 6 million people in the U.S. and has burdened the U.S. healthcare system and caregivers with increases. It is hypothesized that biomarker deterioration starts many years before cognitive decline due to AD, and identifying high-risk subgroups based on biomarker information will expand the window of opportunity during which therapeutic intervention may have the greatest potential for success. This proposal will seek to develop novel statistical methods and new algorithms for subgroup identification and risk prediction for cognitive decline due to AD, through efforts to (1) establish a time-dynamic and personalized statistical classification and prediction framework using tree-based methods; and (2) leverage the Preclinical AD Consortium data to construct classification and prediction algorithms for onset of AD-related clinical symptoms.

PI_NAMEs: ZHU, YUXIN  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Affect;algorithm development;Algorithms;Alzheimer's Disease;Alzheimer's disease diagnosis;Applications Grants;Biological;Biological Markers;biomarker identification;Caregivers;Caring;Classification;classification algorithm;classification trees;Clinical;clinical application;Clinical Trials;clinically relevant;Cognitive;Data;data harmonization;Data Sources;Decision Trees;Dementia;Deterioration;Disease;Early Intervention;Enrollment;Event;flexibility;Follow-Up Studies;forest;Foundations;Genetic;Goals;Healthcare Systems;high risk;Impaired cognition;improved;Individual;innovation;Knowledge;Medical;method development;Methodology;Methods;novel;Outcome;personalized biomarkers;Persons;Population;pre-clinical;prediction algorithm;Process;progression risk;protective factors;prototype;Public Health;Research;Risk;Risk Factors;risk prediction;Sample Size;semiparametric;Statistical Methods;Structure;Subgroup;success;Symptoms;Therapeutic Intervention;Time;Trees

PROJECT_TITLE: Time-Dynamic Tree-Based Methods for Personalized Alzheimer's Disease Prediction

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Declines in attention and memory are a hallmark feature of Alzheimer’s disease, but some degree of cognitive decline is also evident in healthy older adults. This project will assess whether brain connectivity assessed by high-resolution relative to standard resolution diffusion-weighted imaging is more sensitive to both normal age- related cognitive decline and Alzheimer’s disease. Ultimately, results may assist with the early identification of adults who are at heightened risk for atypical cognitive decline and will set the stage for studies that may wish to use this clinically feasible high-resolution magnetic resonance imaging protocol in future aging research.

PI_NAMEs: MERENSTEIN, JENNA L (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Academic Medical Centers;Address;Adult;Affect;Age;age difference;age related;Age-associated memory impairment;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Attention;Brain;Brain imaging;Brain region;career;Clinical;Cognition;Cognitive;Cognitive aging;cognitive performance;Data;Data Set;Diffusion;Diffusion Magnetic Resonance Imaging;Early Diagnosis;Early identification;executive function;Exhibits;Fiber;Functional Magnetic Resonance Imaging;Future;Goals;Grain;Graph;graph theory;gray matter;healthy aging;Image;imaging study;Impaired cognition;Intervention;life span;Link;Liquid substance;Magnetic Resonance Imaging;Measures;Mediating;Memory;Methodology;Modality;Motor;multimodal data;multimodality;Neurocognitive;neuroimaging;novel;older adult;Older Population;Participant;Pathology;Pathway interactions;Prevalence;professor;programs;Protocols documentation;Reporting;Research;Resolution;Resources;Rest;Risk;Rodent;Sampling;segregation;Slice;Speed;standard measure;Structure;System;tau Proteins;Techniques;Testing;theories;Tissues;Training;Translating;Universities;white matter;Work;young adult

PROJECT_TITLE: High-resolution diffusion imaging of brain connectivity in healthy aging and Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Gene Therapy;Genetics;Heart Disease;Nanotechnology

ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative This project will address the clinical failure of synthetic small diameter vascular grafts due to the ingrowth of vascular smooth muscle cells. We are directly altering the vascular smooth muscle cells through non- viral gene delivery of microRNA 145, which is a known regulator of smooth muscle cells. The knowledge gained in this work will improve the treatment of cardiovascular disease in humans.

PI_NAMEs: HINDS, MONICA T (contact);YIM, EVELYN KING FAI

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: Adult;Alcohols;Amination;Anastomosis - action;Animal Model;Apoptosis;Arteries;Autologous Transplantation;Biochemical;Biocompatible Materials;Biodistribution;Blood;Blood flow;Blood Vessels;Bolus Infusion;Brain;Bypass;Cardiovascular Diseases;Cardiovascular system;Cause of Death;cell growth;cell motility;Cell Physiology;Cell Proliferation;Cell Reprogramming;Cells;Characteristics;Chemicals;Chemistry;Clinical;clinically relevant;Coagulation Process;Collaborations;Complex;Coronary artery;cost;cytokine;Data;design;Development;Devices;Diameter;Disadvantaged;Disease;dosage;Dose;Endothelial Cells;endothelial dysfunction;Endothelium;Engineering;Failure;Fibroblasts;Fluorescence;fucoidan;Gene Delivery;Genes;Genetic Markers;Goals;Growth;Growth Factor;Half-Life;healing;Heart;hemocompatibility;High Fat Diet;Homeostasis;Human;Hyperplasia;Immobilization;immunogenicity;Implant;implantation;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;innovation;interest;Intervention;Kidney;Knowledge;Legal patent;Liposomes;Liver;Lung;Macrophage;Materials Testing;Mediating;Metabolism;microRNA delivery;MicroRNAs;Modeling;Modification;monolayer;mouse model;nanoparticle;neointima formation;neutrophil;non-viral gene delivery;nonhuman primate;novel;nucleic acid delivery;nucleic acid-based therapeutics;Nucleic Acids;Organ;Oryctolagus cuniculus;overexpression;Particle Size;Pattern;Peripheral;Phenotype;plasmid DNA;Platelet Activation;Polymers;polypeptide;Prevalence;prevent;Productivity;Proliferating;Proteins;Regulation;Research;response;Role;Side;Smooth Muscle Myocytes;Sterilization;success;Surface;System;Techniques;Technology;Testing;Thrombosis;thrombotic;Thrombus;Toxic effect;Translating;Translations;United States;uptake;Vascular Diseases;Vascular Graft;Vascular Smooth Muscle;Viral;Weight;Work;zeta potential

PROJECT_TITLE: Engineering of biomaterials with controlled biomolecule delivery for cardiovascular applications

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Nanotechnology;Neurodegenerative;Neurosciences

ORG_CITY: MIAMI

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE: Public Health Relevance We propose to develop a biotherapeutic nanogel for Alzheimer’s disease treatment, with unique features of inherent autofluorescence, anti-viral, and anti-inflammatory properties. The proposed research will provide new avenues for the bioengineering of novel therapeutics for AD/ADRD research. The goal is to provide a safe and non-toxic treatment to reduce the oxidative stress and neuroinflammation associated with AD, which will advance the clinical application reducing the side effects and enhancing the treatment efficacy.

PI_NAMEs: VASHIST, ARTI  (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;abeta deposition;absorption;Address;Aducanumab;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;amyloid formation;Anti-Inflammatory Agents;Antibodies;Antioxidants;Area;associated symptom;Binding;Biological Response Modifier Therapy;biomarker identification;biomaterial compatibility;Biomedical Engineering;Biopolymers;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;Brain Diseases;Characteristics;Chitosan;Clinic;Clinical;clinical application;clinical translation;Combined Modality Therapy;Complex;Data;Dendritic Spines;Development;Disease;Disease Progression;Docking;early onset;efficacy study;experience;Flax;Genes;Goals;Growth;Immunology;Impaired cognition;improved;In Vitro;in vivo;in vivo evaluation;indexing;Inflammation;inflammatory marker;inhibitor;Intervention;Learning Skill;Legal patent;Link;Medicine;Memory Loss;Microglia;migration;Mission;molecular dynamics;molecular modeling;mouse model;Mucociliary Clearance;Mus;NanoGel;nanomaterials;nanomedicine;nanoparticle;Nature;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;neuropathology;NF-kappa B;Nose;novel;novel marker;novel therapeutics;Nucleotides;Oxidative Stress;Pathogenesis;Pathology;patient subsets;Patients;Peptides;Persons;Pharmaceutical Preparations;Play;Polymers;polyol;prevent;Production;Property;public health relevance;Reactive Oxygen Species;receptor;Reporting;Research;Role;Route;Senile Plaques;side effect;small molecule;Solid;success;Synapses;System;targeted treatment;tau Proteins;Testing;Therapeutic;therapy development;Thinking;TNF gene;Toxic effect;Translating;Treatment Efficacy;uptake;Viral

PROJECT_TITLE: Development of Biotherapeutic Nanogels for Alzheimers Disease Treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (83)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Myelin, the insulating structure around neuronal axons that makes up ~30% of our brain (consisting of 75% lipids/25% proteins) and is crucial for forming and preserving memories, is degenerated and possibly plays an important role in Alzheimer’s disease (AD), but its extent of degeneration and its interactions with known disease pathologies have not been quantified. We propose to use our novel synchrotron imaging to produce 3D myelin maps and quantify myelin degeneration in subregions of the hippocampus, the brain’s central memory-processing area, to see how myelin interacts with other abnormal processes in AD, including protein accumulation and inflammation. Complementing that with molecular analyses, we aim to fill a knowledge gap about myelin’s spatial degeneration, relationship with important pathology markers in the AD brain, and known lipid and protein dysregulation in AD, paving the way to a detailed understanding of the involvement of this important component of the brain in the disease.

PI_NAMEs: GEORGIADIS, MARIOS  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Age;aging related disease;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;Anatomy;Animal Model;Area;Axon;Biological;Biological Markers;Biology;Brain;Brain region;Cell Communication;Cell Culture Techniques;Cell Physiology;Cells;Cognition;Contralateral;Data;Demyelinations;dentate gyrus;detector;Diffusion Magnetic Resonance Imaging;Disease;entorhinal cortex;exosome;extracellular vesicles;Face;Fiber;Freezing;genetic analysis;Genomics;gray matter;Hippocampus;Histology;human disease;human tissue;Image;imaging modality;Immunohistochemistry;In Vitro;in vivo;Inflammation;innovation;Knowledge;light scattering;Link;lipidomics;Lipids;Literature;Magnetic Resonance Imaging;Maps;Measures;medial temporal lobe;Memory;memory process;Metabolic;Metabolism;meter;Methods;Microglia;Modeling;Molecular;Molecular Analysis;molecular marker;Molecular Profiling;Molecular Target;multidisciplinary;Myelin;myelin degeneration;Myelin Proteins;Myelin Sheath;myelination;nanosized;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;neuroinflammation;Neurons;normal aging;novel;Oligodendroglia;Paraffin Embedding;Pathology;Pattern;Perforant Pathway;Periodicals;Photons;Plasmalogens;Play;Positioning Attribute;preservation;Process;Proteins;Proteomics;quantitative imaging;RNA;Roentgen Rays;Role;Scanning;sex;Signal Transduction;spatial relationship;Specimen;Sphingomyelins;Stains;Structure;Sulfoglycosphingolipids;Synchrotrons;tau Proteins;Testing;Therapeutic;Three-Dimensional Image;Three-Dimensional Imaging;Time;Tissues;tomography;tool;Uncertainty;Vesicle;white matter;Work;X-Ray Medical Imaging

PROJECT_TITLE: Quantifying myelin degeneration in AD

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

ORG_STATE: PA

PHR: Project Narrative R-loops accumulate in many neurodevelopmental disorders and cancers and can impact the localization of important epigenetic regulators. Elucidating the mechanisms by which R-loops can alter the epigenetic landscape during neurodevelopment can aid in identification of new targets for therapeutic intervention in a range of neurological diseases and cancers where R-loops are deregulated.

PI_NAMEs: SARMA, KAVITHA  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: 3-Dimensional;Aberrant DNA Methylation;Affect;Architecture;autism spectrum disorder;Binding;Binding Proteins;Binding Sites;Brain;Chemicals;Child;Chromatin;Chromatin Structure;comparison control;Data;Development;Disease;DNA Damage;DNA Methylation;Enhancers;Epigenetic Process;Etiology;Exhibits;Frameshift Mutation;Gene Expression;Genes;Genetic Transcription;Genome;Genomic Instability;Genomics;Goals;Heterozygote;human induced pluripotent stem cells;Lead;lens;Malignant Neoplasms;malignant neurologic neoplasms;Mediating;Missense Mutation;Mutation;nerve stem cell;Nervous System Disorder;neural;neurodevelopment;Neurodevelopmental Disorder;Neurons;neuroprotection;new therapeutic target;Pathogenicity;patient derived induced pluripotent stem cells;patient retention;Process;programs;promoter;Protein Dynamics;Protein Fragment;Protein Truncation;Proteins;Publishing;rare condition;recruit;Regulation;response;RNA;Role;Site;Syndrome;System;Testing;Therapeutic Intervention;virulence gene;YY1 Transcription Factor

PROJECT_TITLE: R-loop functions in neuronal gene expression and genome organization

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative. Endothelial dysfunction is a major contributor to obesity-induced hypertension. A successful completion of this project will improve our understanding of the molecular mechanisms for endothelial dysfunction in obesity and may identify novel therapeutic targets for lowering blood pressure in obesity.

PI_NAMEs: SONKUSARE, SWAPNIL K. (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Adult;Affect;American;Arteries;Automobile Driving;Blood flow;Blood Pressure;blood pressure elevation;blood pressure reduction;Blood Vessels;Calcium;Calcium Signaling;Cardiovascular Diseases;Cells;clinically relevant;cytokine;Data;diet-induced obesity;Endothelial Cells;endothelial dysfunction;Endothelium;Functional disorder;Goals;High Fat Diet;human subject;human tissue;Hypertension;Immune;Impairment;improved;Individual;Inflammatory;Ion Channel;Knock-out;Knockout Mice;Link;Measurement;Mediating;Mineralocorticoid Receptor;Molecular;new therapeutic target;NOS2A gene;Obese Mice;obese patients;Obesity;Organ;paracrine;Pathogenesis;Pathway interactions;Peroxonitrite;pharmacologic;Play;Production;promoter;Reactive Nitrogen Species;receptor;Receptor Activation;Receptor Inhibition;Receptor Signaling;Resistance;Rest;Risk Factors;Role;Signal Transduction;Skeletal Muscle;Smooth Muscle;Smooth Muscle Myocytes;Tamoxifen;Testing;therapeutic target;TNF gene;Tumor Necrosis Factor Receptor;Vanilloid;Vascular Diseases;vascular inflammation;Vascular remodeling;Vascular Smooth Muscle;vasoconstriction;Vasodilation;Vasodilator Agents

PROJECT_TITLE: Paracrine TNF signaling impairs endothelial TRPV4 microdomains in obesity

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease

ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed research is relevant to the mission of the NIH because a better understanding of the mechanisms by which epithelial cells regulate homeostasis and repair will contribute to treatment of inflammatory intestinal disorders. The proposed work is of particular relevance to inflammatory bowel disease and Ulcerative Colitis.

PI_NAMEs: LACY-HULBERT, ADAM  (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: adverse outcome;Affect;American;Animal Model;Antibodies;Antibody titer measurement;antimicrobial;Autoantibodies;Autocrine Communication;B-Lymphocytes;Bacteria;Binding;biobank;Biological Markers;Cell Culture Techniques;Cell Line;Cell Maintenance;Cells;Chronic;clinical diagnosis;Colitis;Colonic Diseases;Crohn's disease;cytokine;Cytokine Activation;Data;Development;disability;Disease;dysbiosis;Epithelial Cells;epithelial repair;Epithelium;experimental study;Failure;Gene Expression;Genetic study;Grant;gut inflammation;gut microbes;Health;Helicobacter hepaticus;Homeostasis;Human;Immune;Immune Tolerance;Immunity;Immunoglobulin G;immunoregulation;In Vitro;in vivo;Inflammation;Inflammatory Bowel Diseases;Inflammatory Response;Injury;Integrin alphaV;integrin beta6;Integrins;intestinal barrier;intestinal epithelium;Intestines;Laboratories;Life;Mediating;Microbe;microorganism antigen;Mission;Modeling;mouse model;Mucosal Immune Responses;Mucosal Immune System;Mus;Organoids;Paracrine Communication;Pathogenesis;Patients;Peptides;Pharmaceutical Preparations;Phenotype;pre-clinical;prevent;Productivity;Regulation;Regulatory T-Lymphocyte;repaired;Reporter;repository;Research;response;Role;Sampling;Serum;Signal Transduction;Study models;T cell response;T-Lymphocyte;Testing;trafficking;Transforming Growth Factor beta;Ulcerative Colitis;United States National Institutes of Health;villin;Work

PROJECT_TITLE: Regulation of Intestinal Immunity and Repair by Integrins

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Data Science;Genetics;Human Genome;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pneumonia;Pneumonia and Influenza;Prevention

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Pneumonia is the most common cause of death due to infection worldwide and in patients admitted to the intensive care unit (ICU); it is not clear why some patients improve quickly while others do not, despite receiving appropriate therapy. Machine learning offers great opportunity to reveal important early features of response to treatment and predict which patients will be subsequently cured or not. This proposal will use state-of-the-art machine learning using clinical features and local lung host response transcriptomics to predict pneumonia cure, thereby providing opportunities for earlier diagnostic and treatment interventions to promote cure in critically ill patients.

PI_NAMEs: GAO, CATHERINE A. (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Address;adjudication;Advisory Committees;Age;Antibiotic Therapy;Antibiotics;Area;biobank;Biological;Biological Markers;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Bronchoscopy;Cause of Death;Cells;Clinical;Clinical Data;Critical Care;Critical Illness;Data;Data Analyses;Data Set;Databases;deep learning;Development;Diagnostic;direct patient care;Early identification;Early Intervention;Early treatment;Electronic Health Record;Elements;Enhancers;Enrollment;Environment;experience;Fever;Funding;Future;Gene Expression;Gene Expression Profile;genomic data;Genomics;Goals;high dimensionality;Hospital Mortality;Image;Immune response;Immunocompromised Host;Immunology;improved;Infection;Informatics;insight;Intensive Care Units;Intervention;Investigation;Knowledge;Laboratories;Learning;Leukocytosis;Lung;lung injury;Machine Learning;machine learning model;Measures;Mechanical ventilation;Mentors;Mentorship;Methodology;Microbiology;Modeling;Modification;Molecular;mortality;mouse model;multidimensional data;multidisciplinary;multiple omics;Outcome;outcome prediction;Paper;participant enrollment;pathogen;Patient Admission;Patients;Persons;Physicians;Physiological;Pneumonia;Pneumonia Severity Index;pneumonia treatment;Predictive Factor;predictive modeling;procalcitonin;prospective;Publications;recurrent neural network;Regulatory T-Lymphocyte;Research;Research Personnel;Resolution;Respiratory Failure;response;Sampling;scaffold;Scientist;Sepsis;Severity of illness;single-cell RNA sequencing;Site;skills;Steroids;Streptococcus pneumoniae;System;Systems Biology;Techniques;Testing;Therapeutic;Time;Training;transcriptome sequencing;transcriptomic profiling;transcriptomics;Treatment Failure;treatment response;Universities;Work

PROJECT_TITLE: Machine learning to predict cure in severe pneumonia episodes

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (JA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The goal of this proposal is to investigate the significance of different human CD8+ T cell subsets, including those expressing different levels of IL-7 receptor alpha, in health and disease such as Alzheimer’s disease using peripheral blood immune cells, brain cortical organoids and tissue. The results of the proposed study would advance our understanding of how aging alters CD8+ T cells, contributing to the development and progress of age-associated diseases like Alzheimer’s disease.

PI_NAMEs: KANG, INSOO  (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Accounting;Affect;Age;age effect;age related;age related changes;age-related disease;Aging;aging biomarker;aging gene;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Biological;Biological Assay;Brain;brain tissue;CD8-Positive T-Lymphocytes;Cells;Cerebrospinal Fluid;Characteristics;Chronology;Clinical;Cognition;Collaborations;CX3CR1 gene;cytokine;Cytometry;cytotoxic;Dementia;Development;differential expression;Disease;DNA;DNA Methylation;Elements;Epigenetic Process;Flow Cytometry;Gene Expression Profile;Genes;genetic signature;Genetic Transcription;genome-wide;genomic profiles;Goals;Health;healthy aging;high dimensionality;Hippocampus;Homeostasis;Human;human induced pluripotent stem cells;human old age (65+);IL7 gene;IL7R gene;Immune;Immune system;Immunity;Impairment;Individual;Infection;Inflammation;Inflammatory;interest;Interleukin 7 Receptor;Malignant Neoplasms;Memory;Meta-Analysis;methylome;migration;Neurons;Neuropsychology;older adult;Organ;Organoids;Performance;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Population;potential biomarker;Proteins;Reporting;Research;Severities;Signaling Protein;Subgroup;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Tissues;transcriptome;transcriptome sequencing;transcriptomics;young adult

PROJECT_TITLE: Studying the significance of memory CD8+ T cells differentially expressing IL-7 receptor alpha in human aging

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences;Pain Research;Patient Safety;Rehabilitation;Sleep Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: PROJECT NARRATIVE Every year, millions of older adults undergoing surgery suffer from sleep disturbances, including insomnia, linked with poorer surgical recovery, such as postoperative delirium, cognitive decline, and potentially Alzheimer’s disease (AD). This proposal is relevant to public health because it will test whether cognitive-based therapy for insomnia (CBT-I), an existing evidence-based therapy for insomnia and sleep disturbances newly tailored to the surgical patient, is feasible before planned orthopedic surgery and whether it improves sleep and brain health outcomes in those with moderate to severe insomnia. This unique pilot clinical trial will provide novel groundwork for future sleep interventions that may improve brain health outcomes after surgery.

PI_NAMEs: GAO, LEI  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: 3-Dimensional;Abbreviations;actigraphy;Address;Adherence;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Anxiety;anxiety reduction;brain health;Circadian Dysregulation;Circadian Rhythms;Clinical;Clinical Trials;Cognition;Cognitive;cognitive function;Cognitive Therapy;cohort;comorbidity;confusion assessment method;Data;Delirium;Dementia;Diagnosis;diaries;digital;digital delivery;digital intervention;Education;effective therapy;Elements;Enrollment;evidence base;Evidence based treatment;falls;Family;Foundations;Friends;Functional disorder;Funding;Future;geriatric depression;Hybrids;Immune;Impaired cognition;improved;improvement on sleep;Incidence;indexing;innovation;instrumental activity of daily living;interdisciplinary approach;Intervention;Joints;Link;Mental Depression;Methods;Moods;Neurocognitive;neurocognitive disorder;novel;older adult;older patient;Older Population;Operative Surgical Procedures;opioid use;Orthopedic Surgery;Orthopedics;Outcome;Pain;pain sensitivity;Pain Threshold;Patient Compliance;patient variability;Patients;Perioperative;Persons;Physical Function;Physicians;Pilot Projects;Pittsburgh Sleep Quality Index;poor sleep;Population;postoperative delirium;Postoperative Period;primary outcome;programs;Property;Protocols documentation;Psychometrics;Public Health;Questionnaires;Randomized;Recommendation;Recovery;Relaxation Techniques;resilience;satisfaction;Schedule;Self Administration;Severities;Sleep;Sleep Disorders;Sleep disturbances;sleep health;sleep quality;Sleeplessness;Stimulus;Surgical complication;Surveys;Symptoms;tau Proteins;Testing;Time;Training;Training Programs;trait;treatment as usual;United States Department of Veterans Affairs;United States National Institutes of Health;Verbal Rating Scale;virtual;Work

PROJECT_TITLE: A Pilot Study of Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients (SLEEP-BOOST)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Perilipin-2 (Plin2), a surface component of organelles known as lipid droplets, has been shown to accumulate in specific cells within the brains of Alzheimer’s disease (AD) patients and those with APOE4, a gene variant that increases risk of AD. Increased amounts of Plin2 indicates lipid accumulation and dysregulated metabolism. This project aims to determine the effects of lowering Plin2 in the specific brain cells on AD pathologies.

PI_NAMEs: COHEN, SARAH  (contact);JOHNSON, LANCE ALLEN

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Adipose tissue;Affect;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;apolipoprotein E-4;Apoptotic;Astrocytes;Brain;brain cell;Brain Diseases;career development;Cell Separation;cell type;Cells;Cholesterol;Cuprizone;Demyelinations;Diet;diet-induced obesity;Disease;Disease Progression;Environment;Enzymes;Excision;Fibrosis;Foundations;Future;Genes;genetic risk factor;genetic variant;Homeostasis;Impairment;Individual;Inflammation;Inflammatory;inflammatory milieu;insight;Knockout Mice;Knowledge;Late Onset Alzheimer Disease;Lipase;lipid metabolism;lipid transport;Lipids;Liver;liver inflammation;Macrophage;Metabolic;Metabolism;Microglia;Modeling;mouse model;Mus;Myelin;Nerve Degeneration;Neuroglia;neuroinflammation;Neurons;non-alcoholic fatty liver disease;novel;novel therapeutic intervention;Obesity;Organelles;Pathology;Patients;perilipin;Phagocytes;Phagocytosis;Phenotype;Play;Process;Proteins;remyelination;response;Role;Saccule structure;Stenosis;Surface;Testing;Tissues;Training;Work

PROJECT_TITLE: Assessing the role of APOE in glial lipid droplet metabolism and function


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cervical Cancer;Genetics;Human Genome;Infectious Diseases;Precision Medicine;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative Infection with human papillomaviruses (HPV) has been associated with cancers of the cervix, head and neck and the anogenital organs, and these cancers account for at least 5% of all cancers worldwide. In this study, we will develop a new way to stratify these cancers so that we can discover the underlying processes that distinguish the patients who will respond to certain treatments and have good prognosis, from patients whose tumors will not respond and instead progress rapidly. We expect our contribution to be significant because it will tremendously improve our understanding of how to better prevent, diagnose and treat cervical cancer and other HPV-associated cancers.

PI_NAMEs: OJESINA, AKINYEMI IFEDAPO (contact)

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: Alternative Splicing;Alternative Therapies;angiogenesis;Angiogenesis Inhibitors;base editing;bevacizumab;Biological Assay;burden of illness;Cancer cell line;cancer invasiveness;Cell Line;Cervical;Cervix Neoplasms;chemotherapy;Classification;Clinic;Clinical;Clinical Distribution;clinical practice;Clinical Trials;cohort;Country;Dasatinib;Data;Diagnosis;Diagnostic;diagnostic assay;Disparity;DNA Methylation;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Erlotinib;exome;experimental study;FGF2 gene;Gene Expression;Genome;genomic biomarker;Goals;Growth;Gynecologic Oncology Group;hazard;Head Cancer;HPV positive;HPV-High Risk;Human Chromosomes;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Hybrids;improved;Infection;inhibitor;Invaded;Investigation;keratinocyte;machine learning method;Malignant neoplasm of cervix uteri;Malignant Neoplasms;MAPK1 gene;MicroRNAs;Molecular;molecular marker;Motility;Multiomic Data;mutant;Mutation;Neck Cancer;novel diagnostics;novel therapeutic intervention;Organ;Outcome;Pathway interactions;patient response;patient stratification;Patients;Play;premalignant;prevent;Prevention program;Process;Prognosis;Progression-Free Survivals;Proliferating;protein expression;Proteins;Qualifying;Recurrence;Regression Analysis;Reporting;Research;Resistance;Resources;response;response biomarker;Reverse Transcriptase Polymerase Chain Reaction;Risk;RNA Splicing;Role;screening;Signal Pathway;success;Therapeutic;Tissues;Transcript;transcriptome sequencing;treatment strategy;tumor;Tumor Markers;United States;Vaccination;vaccine acceptance;Viral;viral genomics;Viral Markers;whole genome;Xenograft procedure

PROJECT_TITLE: Molecular Markers for Tumors Associated with Extrachromosomal HPV

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Dental, Oral, and Craniofacial Disease;Obesity;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Narrative Degenerative disorders of Temporomandibular Joint (TMJ) are painful and debilitating diseases, affecting over 20 million people in United States. The prevalence of obesity and growth of older population has risen dramatically over the past two decades and it has been observed that obesity accelerates aging. Our application proposes to understand the role of p21–highly-expressed (p21high) cells in TMJ degeneration and underlying mechanism by which p21high cells modulate TMJ degeneration.

PI_NAMEs: YADAV, SUMIT  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Acute Pain;Address;Affect;age acceleration;age related;age-related disease;aged;Aging;aging population;Automobile Driving;Cartilage;Cartilage injury;Cell Aging;cell type;Cells;chronic pain;Clinical;cost;Coupled;Data;Degenerative Disorder;Deterioration;Disease;Disease Progression;effective therapy;Elderly;Enterobacteria phage P1 Cre recombinase;Epidemic;FDA approved;Financial Hardship;Future;Genes;Genetic;global health;Goals;Growth;Heterogeneity;Homeostasis;Impairment;In Vitro;in vivo;Incidence;Incisor;inducible Cre;Inflammatory Response;inhibitor;innovation;insight;Intervention;joint destruction;joint injury;Joint repair;Knowledge;LoxP-flanked allele;mechanical load;Mechanics;Metals;Methodology;Modeling;Molecular;Molecular Biology;Monitor;mouse model;Mus;novel;Obese Mice;obese person;Obesity;old mice;Older Population;osteochondral tissue;Pain;Pathway interactions;Patients;Persons;pharmacologic;Play;Population;Prevalence;prevent;promoter;Public Health;Publishing;Quality of life;Regulatory Pathway;repaired;Replacement Arthroplasty;research clinical testing;Risk Factors;Role;senescence;senescent cell;senolytics;Societies;Synovial joint;Techniques;Temporomandibular Joint;Temporomandibular Joint Disorders;Testing;Therapeutic;Therapeutic Intervention;transcriptomics;Transgenic Mice;Trauma;Traumatic injury;United States;Work

PROJECT_TITLE: Targeting P21 positive senescent cells for alleviating TMJ degeneration

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Neurosciences;Opioids;Pain Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: INDIANAPOLIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: NARRATIVE Chronic pain and disability after bone fracture are common. We have identified a new targeted bone healing agent that may not only improve bone healing but when coupled with other FDA-approved medications may decrease associated pain. The latter could serve as an important step in fighting the current opioid crisis.

PI_NAMEs: KACENA, MELISSA A;OBUKHOV, ALEXANDER G.;WHITE, FLETCHER A (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Abdomen;Acute;Acute Pain;addiction;Address;afferent nerve;aging population;Analgesics;Animals;antagonist;Behavioral;Behavioral Assay;Biological Assay;Bioluminescence;Biosensor;bone fracture repair;bone fragility;bone healing;bone loss;Bone Pain;bone repair;Bone Resorption;Bone Tissue;Calcitonin;Calcitonin Gene-Related Peptide;Capsaicin;CASP1 gene;Chest;Chronic disability;chronic pain;chronic painful condition;Clinic;clinical pain;Coupled;cytokine;Data;Development;disability;Drug usage;DTR gene;FDA approved;Female;Femoral Fractures;fighting;Fracture;Frequencies;Genes;healing;Health;Healthcare Systems;Impaired cognition;Impairment;improved;In Vitro;in vivo;Individual;Inflammasome;Inflammation;Inflammation Process;Inflammatory;injured;Injury;innovation;insight;Kidney Failure;limb injury;Lower Extremity;male;Mechanics;Mediating;Monitor;Monoclonal Antibodies;mouse model;Mus;Nerve Fibers;Neurons;Neuropathy;Neuropeptides;Nociception;Nociceptors;non-opioid analgesic;Non-Steroidal Anti-Inflammatory Agents;novel;Operative Surgical Procedures;Opioid;opioid epidemic;Opioid Receptor;opioid sparing;opioid use;Orthopedic Surgery;Osteoblasts;osteogenic;Outcome;Pain;Pain management;pain outcome;pain relief;Pathogenesis;Patients;peptide drug;Peptide Signal Sequences;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Phase;Physiological;Play;polypeptide;Population;Postoperative Pain;Postoperative Period;pre-clinical;Prevention;Process;receptor;Recovery;Regulation;Reporter;Resolution;Role;side effect;Signal Transduction;skeletal;skeletal injury;Skeleton;Stimulus;substantia spongiosa;Surgical Models;surgical pain;targeted delivery;Testing;therapeutic evaluation;Time;Trauma;treatment group;Treatment outcome;TRPV1 gene;Ulcer;United States;Vanilloid;Ventilatory Depression;Work

PROJECT_TITLE: Novel treatments of fracture repair and bone pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Hypertension;Kidney Disease

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Public Health Relevance Statement (Narrative) Hypertension is a leading cause of stroke, age related vascular dementia and end-stage renal disease, which places a heavy burden on our economy and contributes to health disparities. Pressure-induced constriction of renal vessels is one mechanism that protects the delicate microvasculature of the kidney from injury associated with increases in systemic blood pressure; however, the mechanism(s) underlying initiation of the response is unknown. This proposal will determine the importance of members of the ENaC/Degenerin family of ions channels and TrpC6 channels in the initiation of pressure-induced constriction, and the role of these channels in protecting the kidney from hypertension related injury.

PI_NAMEs: DRUMMOND, HEATHER A (contact);KLEYMAN, THOMAS R

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: Acceleration;Address;age related;Agonist;Animals;Aortic coarctation;arteriole;ASIC channel;Attenuated;Biological Assay;Biological Models;Blood flow;blood pressure elevation;Blood Vessels;Cardiovascular Diseases;cell type;Cells;cerebral artery;Characteristics;Chronic Kidney Failure;constriction;Couples;Coupling;Data;Dysbarism;Electrophysiology (science);End stage renal failure;epithelial Na+ channel;Event;Exhibits;Family;Family member;Glomerular Capillary;health disparity;high salt diet;Hypertension;Injury;Injury to Kidney;Ion Channel;Kidney;kidney vascular structure;Knock-out;Knockout Mice;mechanical force;mechanical signal;Mechanoreceptors;mechanotransduction;Mediating;member;Modality;Modeling;Molecular;mouse model;Multiphoton Fluorescence Microscopy;Mus;mutant mouse model;NG-Nitroarginine Methyl Ester;Norepinephrine;novel;Organ;Predisposition;pressure;prevent;Prevention;Process;Property;public health relevance;Reflex action;Reporting;response;Role;shear stress;Signal Transduction;Smooth Muscle Myocytes;Speed;Stimulus;Stretching;Stroke;System;Systemic blood pressure;Testing;therapeutic target;Tissues;transcriptomics;transmission process;TRP channel;vascular bed;Vascular Dementia;vascular injury;Vascular Smooth Muscle;vasoconstriction;Xenopus oocyte

PROJECT_TITLE: Degenerin and TrpC6 channels in renal vascular mechanosesnsor signaling and protection against injury.


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_CITY: Los Angeles

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative  Melanin-concentrating hormone (MCH) is a peptide produced in the brain that stimulates eating, and there is interest in developing obesity pharmacotherapies that block this system. However, despite its known role in increasing food intake and body weight, very little is understood about the biological mechanisms through which MCH influences energy balance. This proposal will unravel the specific physiological and neural mechanisms through which MCH influences food intake regulation.

PI_NAMEs: KANOSKI, SCOTT EDWARD (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;Adult;adverse outcome;Anatomy;Animals;Anti-Obesity Agents;Appetite Stimulants;Attention;Automobile Driving;Autoradiography;awake;bariatric surgery;Behavioral;Behavioral Mechanisms;Biological;Body Weight;Body Weight decreased;Brain;Brain Mapping;Calcium;Carbohydrates;Caspase;Central Nervous System;Child;Chronic;Consumption;Data;detection of nutrient;Development;Eating;effective therapy;energy balance;Equilibrium;Event;experimental study;Feedback;feeding;Feeding behaviors;Fiber;food consumption;Food Intake Regulation;Frequencies;Funding;gain of function;Gene Expression Profile;Genetic;Glucose;Health Care Costs;hormonal signals;hormone deficiency;Hypothalamic structure;Image;Infusion procedures;Injections;Intake;interest;Lateral Hypothalamic Area;Learning;Light;Lipids;Literature;loss of function;Measures;Mediating;melanin-concentrating hormone;Metabolic;Nausea;neural;neural network;Neuroanatomy;Neurobiology;neuromechanism;Neurons;Neuropeptides;novel;Nutrient;Obesity;obesity treatment;Oral;overexpression;Pathway interactions;Pattern;Peptides;pharmacologic;Pharmacotherapy;Photometry;Physiological;Population;preference;Process;Rattus;receptor;Regulation;response;Rodent;Role;Satiation;side effect;single nucleus RNA-sequencing;Stimulus;Stomach;success;Sweetening Agents;System;Thinness;Transgenic Organisms;weight loss intervention;zona incerta

PROJECT_TITLE: Control of feeding behavior by melanin-concentrating hormone

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Immunotherapy;Organ Transplantation;Prevention;Rare Diseases;Regenerative Medicine;Transplantation

ORG_CITY: LA JOLLA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Clinical solid organ transplantation requires life-long immunosuppression to prevent allograft rejection. Current immunosuppressive strategies rely primarily on broad pharmacologic inhibition of lymphocyte function, which is incompletely effective at preventing rejection while increasing the risk for infection and tumors. Thus, new approaches for specific and durable allograft-specific immunosuppression are critically needed. We propose to utilize a pMHCII-based allogeneic 5-module chimeric antigen receptor-cytotoxic T cell (5MCAR-CTL) system to target and eliminate alloreactive T cells. Successful completion of the proposed experiments will generate tools and data to support refinement and development of this clinically-translatable cell engineering approach.

PI_NAMEs: KUHNS, MICHAEL S;MORRIS, GERALD PATRICK (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acute;Acute Graft Versus Host Disease;Address;Allogenic;allograft rejection;Allografting;Alloimmunization;B-Lymphocytes;base;CD4 Positive T Lymphocytes;Cell Transplantation;Cells;cellular engineering;chimeric antigen receptor;Clinical;clinical development;clinical translation;clinically relevant;Cytotoxic T-Lymphocytes;Data;experimental study;Expression Library;graft vs host disease;heart allograft;Hematopoietic Stem Cell Transplantation;Immune response;Immune system;Immunization;Immunosuppression;Impairment;improved;In Vitro;in vivo;Infection;infection risk;innovation;Investigation;Isoantibodies;Libraries;Ligands;Lymphocyte;Lymphocyte Function;Measures;Mediating;Modality;Modeling;mouse model;novel;novel strategies;Organ;Organ Transplantation;Outcome;Pathologic;Patients;Peptide Library;Peptide/MHC Complex;Peptides;pharmacologic;Predisposition;prevent;Production;receptor;response;Role;Solid;Specificity;System;T cell response;T-Lymphocyte;Technology;Testing;tool;Transplantation;tumor

PROJECT_TITLE: Use of allogeneic pMHCII-based 5MCAR-CTLs to eliminate alloreactive lymphocytes in transplant

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-L (02)]


ADMINISTERING_IC: CE

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PI_NAMEs: SAMUELS, ELIZABETH ANNE (contact)

PROJECT_TITLE: CE22-010, Rigorous Evaluation of Strategies to Prevent Overdose through Linking People with Illicit Substance Use Disorders to Recovery Support Services - 2022


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: This renewal would continue the tradition of innovative training for top-notch neuroscientists at Washington University. The proposed Neuroscience Pipeline will prepare underrepresented students for graduate-level studies through advanced educational and research experiences, intensive advising and dedicated community outreach. These efforts, combined with our mentor training and evaluation plans, should be scalable and findings translatable to those who share our goals of changing the local culture of mentoring future scientists and increasing diversity in the neurosciences.

PI_NAMEs: HERZOG, ERIK  (contact)

PROGRAM_OFFICER_NAME: JONES, MICHELLE

PROJECT_TERMS: Address;Adopted;African American;African American population;Awareness;Bees;Brain;cohort;college;Communication;Communities;community building;Community Outreach;Dedications;Development;Doctor of Philosophy;doctoral student;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Ensure;Environment;Evaluation;experience;Faculty;First Generation College Students;Future;General Population;Goals;graduate school;graduate student;Grant;High School Student;improved;innovation;Institution;interest;Knowledge;Laboratories;Latino;Latino Population;leadership development;Learning;Literature;Measures;Mediating;Mentors;Midwestern United States;Missouri;Molecular;Native Americans;Neuronal Dysfunction;Neurophysiology - biologic function;Neurosciences;Neurosciences Research;notch protein;novel;Oral;Outcome;Outcome Measure;Outcomes Research;outreach;peer;peer coaching;peer support;Perception;Population;Preparation;Process;programs;Published Comment;Reading;Research;Research Personnel;Science;Scientist;Self Efficacy;skills;Societies;Students;success;support network;symposium;Synapses;System;Techniques;Testing;Time;Training;Training Programs;trend;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Washington;Writing

PROJECT_TITLE: BP-ENDURE: The St. Louis Neuroscience Pipeline


NIH_SPENDING_CATS: Breast Cancer;Cancer;Machine Learning and Artificial Intelligence;Palliative Care;Patient Safety;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE In this project we will develop new methodology to predict a patient’s likelihood of developing a chronic condition and identify patients that need closer monitoring based in decline in quality of life and heavy symptom burden. Our methods will influence early intervention to manage symptoms, and will be evaluated prospectively within high risk, early-stage breast cancer settings.

PI_NAMEs: SOMANI, AMRITA BASU (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: active method;Adverse event;Affect;Algorithms;arm;Breast;Breast Cancer therapy;cancer clinical trial;Caring;Chronic;Clinical;clinical care;Clinical Trials;cohort;computer framework;Cues;Data;Data Reporting;Data Set;Deterioration;Development;Diarrhea;Distress;Drug toxicity;Early Intervention;efficacy evaluation;electronic patient reported outcomes;Event;experience;explainable machine learning;Fatigue;follow-up;Future;Health;health related quality of life;high risk;Impairment;improved;Individual;innovation;Intervention;Knowledge;Machine Learning;Malignant Breast Neoplasm;Maximum Tolerated Dose;Measures;Methodology;Methods;Modeling;Monitor;Neoadjuvant Therapy;Neuropathy;oncology trial;Participant;patient oriented;Patient Outcomes Assessments;Patients;personalized care;Pharmaceutical Preparations;Physical Function;prediction algorithm;predictive modeling;primary outcome;prospective;Provider;Quality of life;Reporting;Research;Resources;Risk;Serious Adverse Event;Severities;side effect;Site;Supportive care;Surveys;Symptom Burden;symptom cluster;symptom management;Symptoms;Testing;Time;Toxic effect;treatment effect;Treatment Side Effects;trial comparing;Visualization;women's treatment

PROJECT_TITLE: Analyzing Patient-Level Data in a Breast Cancer Clinical Trial

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE This project will benefit public health by supporting basic, translational, and clinical research on frontotemporal dementia and related neurodegenerative diseases of aging.

PI_NAMEs: GORNO TEMPINI, MARIA LUISA  (contact);ROSEN, HOWARD J;SEELEY, WILLIAM W

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Acceleration;aging related disease;Alzheimer disease detection;Alzheimer's Disease;Amyloid;Anatomy;Autopsy;Basic Science;behavioral variant frontotemporal dementia;Biological Markers;Biology;biomarker discovery;biomarker validation;Biometry;caregiver interventions;Caregiver well-being;Caregivers;Clinical;clinical heterogeneity;Clinical Research;clinical translation;clinical trial enrollment;Clinical Trials;Cognitive;cognitive process;Collaborations;Consultations;Data;data access;data management;data quality;Dementia caregivers;design;Diagnosis;Diagnostic;Disease;Emotional;Emotions;Ensure;exome sequencing;Face;Family;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Functional disorder;functional MRI scan;Gene Expression Profiling;Genes;Genetic;Goals;Grant;Health;Heterogeneity;Human Genetics;Image;improved;in vivo;innovation;International;Intervention;Knowledge;knowledge translation;Laboratories;Language;Lead;Link;Liquid substance;loss of function;Methods;Modeling;Modernization;Molecular Diagnosis;molecular diagnostics;Molecular Disease;molecular marker;Monitor;MRI Scans;Nerve Degeneration;Network-based;neural;Neurodegenerative Disorders;neuroimaging;neuropathology;Neuropsychology;novel;novel therapeutics;Outcome Measure;outreach;Pathogenesis;Pathogenicity;Pathology;Patient Participation;Patient Selection;Patients;Plasma;poor health outcome;Population;Populations at Risk;Positron-Emission Tomography;Primary Progressive Aphasia;Process;Productivity;prognostication;Program Research Project Grants;protein TDP-43;Proteomics;Public Health;Recording of previous events;recruit;Research;Research Methodology;resilience factor;risk variant;Sample Size;Sampling;social;Sorting;Source;Specimen;success;Syndrome;System;tau Proteins;Technology;Therapeutic;Tissues;tool;transcriptomics;Translating;Translational Research;United States National Institutes of Health;Variant

PROJECT_TITLE: Frontotemporal Dementia: Genes, Images, and Emotions


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Patient Safety;Racial and Ethnic Minority Health Research;Rare Diseases

PI_NAMEs: GORNO TEMPINI, MARIA LUISA  (contact)

PROJECT_TERMS: Acceleration;Accountability;Adherence;Alzheimer's Disease;Asian Americans;Attention;Awareness;Behavioral;behavioral variant frontotemporal dementia;Biological;Caregivers;caregiving;Clinical;Clinical Trials;Cognitive;cognitive neuroscience;cohort;Collaborations;Communication;Communities;Core Grant;corticobasal syndrome;data sharing;Dementia;diagnostic criteria;Discipline of Nursing;Disease;diversity and inclusion;Education;Emotional;Emotions;Ensure;Ethics;Event;Family Caregiver;Fertilization;Fostering;Frontotemporal Dementia;Future;Genes;Genetic;Goals;Health;Heterogeneity;Human;Human Resources;human subject protection;Image;improved;Infrastructure;insight;Institution;International;Language;Latinx;Laws;Leadership;Longitudinal cohort;Manuals;Measures;meetings;Mentors;Mentorship;Minority Groups;molecular marker;Molecular Profiling;Monitor;Nature;neuroimaging;novel;Online Systems;Output;outreach;Pacific Islander;Participant;Pathologic;Pathology;Patients;PGRN gene;Policies;Primary Progressive Aphasia;Productivity;Program Research Project Grants;programs;Progressive Aphasias;Progressive Supranuclear Palsy;quality assurance;Quality Control;recruit;Regulation;Reporting;Research;Research Personnel;Resources;San Francisco;Scientist;Secure;Shapes;social media;social stigma;success;Syndrome;synergism;tau Proteins;Therapeutic;tool;Translating;Underrepresented Populations;United States National Institutes of Health;Universities;usability;Variant;Vulnerable Populations

PROJECT_TITLE: Administration


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: MILLER, BRUCE L (contact)

PROJECT_TERMS: Activities of Daily Living;Affective;Age;Alzheimer's Disease;Alzheimer's disease patient;Attitude;automated algorithm;Autopsy;Behavior;Behavioral;behavioral variant frontotemporal dementia;Biological Markers;Caregiver Burden;Caregivers;Caring;Clinical;clinical care;clinical practice;Clinical Trials;Cognitive;cohort;Collection;Communities;Community Outreach;Core Grant;corticobasal syndrome;COVID-19;Data;Data Set;Dementia;design;Development;Diagnosis;Diagnostic;diagnostic criteria;digital;Disease;Early Diagnosis;Emotional;Emotions;Ensure;Europe;Evaluation;Evaluation Research;experience;Facial Expression;Faculty;Faculty Recruitment;Family;Family Caregiver;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Funding;Genes;Genetic;Goals;Health;Heterogeneity;Home;Hong Kong;Hybrids;Image;improved;in vivo evaluation;Individual;innovation;insight;International;Knowledge;Language;Latin America;Lead;Leadership;Linguistics;Liquid substance;machine learning algorithm;Maintenance;Measurement;Measures;member;Modeling;Molecular;Molecular Diagnosis;molecular marker;Monitor;Motor Neuron Disease;National Institute on Aging;neural;Neurologic;neuropathology;Neurosciences;Online Systems;outreach;pandemic disease;Participant;Pathologic;patient population;Patient Recruitments;Patient-Focused Outcomes;Patients;personalized approach;Persons;Phenotype;Plasma;Population Heterogeneity;Primary Progressive Aphasia;Procedures;Program Research Project Grants;Progressive Aphasias;Progressive Supranuclear Palsy;Recording of previous events;recruit;remote assessment;Research;research clinical testing;resilience;response;Scientist;Semantics;Site;social;South America;Speech;Standardization;Symptoms;Syndrome;Taiwan;Techniques;Technology;Telephone;Testing;Therapeutic;tool;Training;Translating;treatment strategy;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Variant;Visit;web-based assessment

PROJECT_TITLE: Clinical


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Data Science;Dementia;Frontotemporal Dementia (FTD);Genetics;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: RANKIN, KATHERINE P (contact)

PROJECT_TERMS: Acceleration;accurate diagnosis;analytical method;analytical tool;Area;Back;Biometry;Biostatistics Core;Clinical;Clinical Research;Code;cohort;Collaborations;Complex;complex data;complex modeling;Consultations;Creativeness;Data;Data Analyses;data exploration;data integration;data management;Data Management Resources;data quality;Data Science;Data Set;data sharing;Databases;design;Early Diagnosis;Emotions;Ensure;experience;Frontotemporal Dementia;Genes;Genetic;genetic signature;Goals;Human Resources;Image;improved;Individual;information gathering;Infrastructure;innovation;insight;Knowledge;Link;Magnetic Resonance Imaging;Methodology;Methods;Modality;Modeling;Molecular;multidimensional data;Neuroanatomy;neuroimaging;neuropathology;Neuropsychology;open data;Participant;Patients;Phenotype;precision medicine;Procedures;programs;proteomic signature;Protocols documentation;Recommendation;Research;Research Design;Research Methodology;Research Personnel;Resources;Signs and Symptoms;Specimen;Statistical Data Interpretation;Structure;support tools;Syndrome;Therapeutic;tool;Visualization;Work

PROJECT_TITLE: Data Management and Biostatistics


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: SEELEY, WILLIAM W (contact)

PROJECT_TERMS: Acceleration;Address;Alzheimer's Disease;anatomic imaging;Anatomy;Autopsy;Basic Science;Biological Markers;biomarker discovery;Biostatistics Core;Brain;Brain Diseases;brain tissue;Cells;Clinical;clinical conference;clinical translation;Collaborations;Complex;Consensus;Data;Data Correlations;data management;Databases;Dementia;Development;Diagnosis;Diagnostic;digital;Disease;Emotions;Equipment and supply inventories;Event;Faculty;Fellowship;Freezing;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Future;Genes;Genetic;Goals;Grouping;Health Insurance Portability and Accountability Act;Histologic;Human;Image;improved;innovation;International;knowledge translation;Laboratories;Life;Link;Liquid substance;loss of function;Management Information Systems;method development;Methods;Molecular;molecular imaging;molecular marker;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;Neurologist;Neurology;neuropathology;Neuropsychology;Neurosciences;next generation;novel therapeutics;Participant;Pathogenicity;Pathologic;Pathology;Patients;Play;primary outcome;protein TDP-43;Qualifying;Research;Research Personnel;Research Support;Resources;Role;Rotation;Running;Sampling;Scanning;Scientist;Secure;Slide;Source;Specimen;Spinal Cord;Stains;symposium;tau Proteins;Therapeutic;tissue resource;Tissues;Training;Translational Research;Validation;Work

PROJECT_TITLE: Neuropathology


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Immunotherapy;Lymphatic Research;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_DEPT: CHEMISTRY

PHR: Narrative. Communication between the lymph node and the organs it drains is imperative for predicting immune responses to vaccination, infection, and chronic disease, but have been difficult to study in vivo or in vitro. To address this gap, we will develop a user friendly, microscale system specifically co-culture intact samples of live tissue from the lymph node with other organs and allow recirculating of white blood cells between them as occurs in vivo. After determining the effects of various modes of fluid motion on intact lymph node tissue for the first time, we will generate a simple model the response of the lymph node to vaccination, as a proof-of-principle of this new system for modeling multi-tissue immunity outside the body.

PI_NAMEs: POMPANO, REBECCA R (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: 3D Print;Address;Adjuvant;Adopted;Adoption;Air;Antigen Presentation;Antigen-Antibody Complex;Antigens;Arthritis;Autoimmunity;Bathing;Biological Models;Biology;biomaterial compatibility;Biomedical Research;Brain;cancer immunotherapy;Cancer Vaccines;Cell Culture Techniques;Cell Survival;Cells;Chronic Disease;Circulation;Coculture Techniques;Communication;Communities;Complex;cooking;design;Disease;Drainage procedure;draining lymph node;effector T cell;Electronics;Engineering;Ensure;Environment;Event;experimental study;fighting;fluid flow;Force of Gravity;Gel;Hybrids;Image;Immune;immune function;Immune response;Immunity;Immunologist;Immunology;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Incubators;Infection;Inflammation;Inflammatory;Injections;innovation;interstitial;Joints;Laboratories;Lateral;Leukocytes;Liquid substance;Lymph;lymph node microenvironment;Lymph Node Tissue;lymph nodes;Lymphocyte;lymphoid organ;Magnetism;Methods;microdevice;Microfluidics;miniaturize;Modeling;Molecular;Monitor;Motion;Movement;Organ;Organ Culture Techniques;Organ Model;organ on a chip;Particulate;Pattern;Perfusion;Peripheral;predicting response;preservation;Proteins;prototype;Public Health;Pump;recruit;Reporting;Reproducibility;Research Personnel;response;Sampling;scale up;Series;simulation;Site;Skin;Slice;Stimulus;Stromal Cells;System;technology development;Testing;therapeutic evaluation;Time;Tissue Microarray;Tissues;tumor;Tumor Immunity;usability;user-friendly;Vaccination;Vaccine Design;vaccine immunogenicity;Vaccines;Viscosity;Work

PROJECT_TITLE: Multi-organ culture and pumping systems for ex vivo models of immunity in hybrid tissue-chips

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: ROSEN, HOWARD J (contact)

PROJECT_TERMS: accurate diagnosis;Advanced Development;Affect;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer’s disease biomarker;Amyloid;archive data;Archives;arterial spin labeling;Atlases;Behavioral Symptoms;behavioral variant frontotemporal dementia;Binding;Biological Markers;Biology;Biostatistics Core;Blood;blood-based biomarker;Brain;brain behavior;Brain imaging;Caregivers;Classification;Clinical;Clinical Trials;Cognitive;Collection;Consultations;corticobasal syndrome;Data;Data Analytics;data archive;data management;Databases;dementia care;Development;Diagnosis;Diagnostic;Diagnostic Imaging;diagnostic value;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;emotional behavior;Emotions;executive function;experience;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Functional Magnetic Resonance Imaging;Gene Expression;Genes;Goals;gray matter;Health;Heterogeneity;Image;image archival system;imaging modality;interest;Knowledge;Language;Magnetic Resonance Imaging;Maintenance;Maps;Measurement;Measures;Modality;molecular marker;molecular pathology;Nerve Degeneration;Neuroanatomy;Neurobehavioral Manifestations;Neurodegenerative Disorders;neuroimaging;novel;novel marker;Outcome Measure;Participant;Pathology;Patients;Perfusion;Play;Positron-Emission Tomography;Primary Progressive Aphasia;Process;Progressive Supranuclear Palsy;protein expression;protein TDP-43;Research;Research Personnel;resilience;Role;Secure;Semantics;serial imaging;Social Behavior;Speech;Structure;Syndrome;tau Proteins;Therapeutic Intervention;Time;tool;Tracer;Variant;Visit;white matter;Work

PROJECT_TITLE: Imaging


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Methamphetamine;Prevention;Racial and Ethnic Minority Health Research;Stimulant Use and Misuse;Substance Misuse

PHR: Project Narrative Methamphetamine use disorder – MUD – is a serious problem in the US and worldwide; treatment options and understanding of its underlying biology are severely limited. Large-scale genomewide studies are a proven method to increase knowledge of a disorder's biology, and accordingly, we propose collection of 10,000 subjects in Thailand ascertained for MUD and other substance use and psychiatric traits, to conduct a whole- genome sequencing analysis; these will be meta-analyzed with other MUD samples. Results from this study have the potential to advance greatly our understanding of genetic risk factors for MUD, and therefore of MUD biology, especially in understudied East Asian populations.

PI_NAMEs: GELERNTER, JOEL  (contact);POTENZA, MARC N

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Address;African ancestry;Asia;Asian;Asian ancestry;Asian population;Behavior;biobank;Biology;causal variant;Chromosome Mapping;Clinical;cohort;Collaborations;Collection;Communities;Copy Number Polymorphism;cost;Country;Data;Data Set;Dedications;Diagnosis;Disease;disorder control;disorder risk;DNA;Drug abuse;Drug Use Disorder;East Asian;Epidemic;European ancestry;Faculty;gene discovery;Genetic;genetic analysis;Genetic Diseases;Genetic Risk;genetic risk factor;Genetic study;genome analysis;genome sequencing;genome wide association study;genome-wide;Genomics;Genotype;Grant;Heritability;Heterogeneity;Hospitals;Human;Human Genetics;improved;in silico;Individual;Infrastructure;instrument;International;Knowledge;Maps;Medicine;Memory;Mental disorders;Mental Health;Meta-Analysis;Methamphetamine;Methamphetamine use disorder;Methods;Modeling;Neurobiology;neuroimaging;Participant;Pattern;Pharmaceutical Preparations;phenome;Phenotype;pleiotropism;Population;Prevention;Principal Investigator;programs;psychiatric genomics;Psychiatric Hospitals;Psychopathology;Public Health;recruit;Research;risk variant;sample collection;Sampling;Sampling Studies;Site;substance use;Substance Use Disorder;Taiwan;Thailand;Time;trait;Underrepresented Populations;Universities;Variant;Veterans;whole genome;Work

PROJECT_TITLE: Methamphetamine and Other Substance Use Disorder Genetics in Thailand

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Most cells in adult animals are in a non-cycling, quiescent state often referred to as G0. Some cells enter reversible states of G0 while others enter more robust and permanent states of G0, but the differences between reversible G0 and permanent G0 are poorly understood. This work investigates the molecular mechanisms that control different states of G0 across tissues, with an ultimate goal of generating tools to manipulate and control G0, which becomes improperly regulated in both cancer and aging.

PI_NAMEs: BUTTITTA, LAURA A (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Aging;Biological;Cell Cycle;Cell Cycle Inhibition;Cell Cycle Regulation;Cells;daughter cell;Development;Event;flexibility;G0 Phase;Goals;Malignant Neoplasms;mature animal;Metabolic;Molecular;Nutrient availability;Organ;Organism;Pathway interactions;Physiological;Process;Production;response;Series;Signal Transduction;tissue regeneration;Tissues;tool;Work;zygote

PROJECT_TITLE: Probing the flexibility of G0

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetic Testing;Genetics;Human Genome;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Rare Diseases

PI_NAMEs: YOKOYAMA, JENNIFER S (contact)

PROJECT_TERMS: Alzheimer's Disease;autosomal dominant mutation;autosome;Back;Bioinformatics;Biological Assay;Biological Markers;Blood;career;case-based;Clinical;clinical practice;cohort;cost;Data;Data Analyses;data management;data sharing;Dedications;Dementia;Development;Disease;DNA;Emotions;Enrollment;Environment;Etiology;exome sequencing;Fostering;Foundations;Frontotemporal Dementia;Functional disorder;Funding;Future;gene discovery;Gene Mutation;Generations;Genes;Genetic;genetic approach;genetic architecture;Genetic Counseling;genetic information;Genetic Risk;genetic risk factor;Genetic Screening;Genetic study;genetic testing;genome resource;genome sequencing;genome-wide;Genomic approach;Genomics;Genotype;Goals;Heritability;Image;Individual;Informatics;Infrastructure;Institution;interdisciplinary collaboration;International;Large-Scale Sequencing;Learning;Link;Maps;Medical Genetics;Mentors;Methods;Mining;molecular marker;multidisciplinary;multiple omics;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;neurogenetics;neuropathology;next generation sequencing;novel;Participant;Pathogenicity;Pathologic;Patients;Population;precision medicine;programs;Publications;recruit;Reporting;repository;Research;Research Personnel;research study;Resources;Risk Factors;risk variant;RNA;Role;sample collection;Sampling;screening;SNP array;Stratification;Subjects Selections;success;Therapeutic;Time;tool;Training;transcriptome sequencing;transcriptomics;Trinucleotide Repeat Expansion;whole genome;Work

PROJECT_TITLE: Genetics


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Molecular communication across cell types is central to life—communication between cell types in a human organ is critical to normal function, and microbe-host or microbe-microbe communication drives microbial ecosystems. This proposal will study signaling between human immune cells and fibroblasts and signaling between microbes relevant for human health (e.g., commensal and pathogenic bacteria and fungi). We will develop a suite of microfluidic tools to broaden the scope of mechanistic questions that can be addressed, ultimately enabling the development of therapies to target dysfunctional signaling and inflammation in human disease.

PI_NAMEs: THEBERGE, ASHLEIGH BROOKS (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;Affect;Area;B-Lymphocytes;Bacteria;Biological Assay;Biological Process;Biomedical Engineering;Biomimetics;Blood capillaries;cell type;Cells;Chemical Stimulation;Chemicals;commensal bacteria;commensal microbes;Communication;Complex;cost effective;Development;Disease;Ecosystem;Engineering;eosinophil;experimental study;Fiber;Fibroblasts;fungus;Future;Health;Home;Human;human disease;Immune;Immune response;Inflammation;Inflammatory;innovation;Investigation;Life;Mass Fragmentography;Mediating;Methods;Microbe;microbial;microbial community;Microfluidics;Molecular;monocyte;neutrophil;novel;novel strategies;Organ;paracrine;Paracrine Communication;pathogen;pathogenic bacteria;Phase;Positioning Attribute;Production;Role;sample collection;Sampling;Signal Transduction;Signaling Molecule;Signaling Protein;small molecule;Solid;System;therapy development;Time;tool;Translating;user-friendly;Vocabulary;volatile organic compound;Volatilization;Work

PROJECT_TITLE: Deciphering the role of chemical signals in inflammation with open microfluidic functional assays


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: BOXER, ADAM L. (contact)

PROJECT_TERMS: accurate diagnosis;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Amyloid beta-42;aptamer;Biological Assay;Biological Markers;Biological Specimen Banks;biomarker development;biomarker discovery;biomarker identification;Biostatistics Core;Blood;Categories;cell bank;Cell Culture Techniques;Cell Line;cell preparation;Cells;Classification;Clinical;clinical diagnosis;Collaborations;Collection;Communities;Data;Data Collection;data management;Data Set;Development;diagnostic biomarker;Disease;DNA;Early Diagnosis;Emotions;Epithelium;Evaluation;experience;Fibroblasts;follow-up;Frontotemporal Dementia;Functional disorder;Generations;Genes;Genotype;Glial Fibrillary Acidic Protein;Heterogeneity;Human;Image;improved;induced pluripotent stem cell;Infrastructure;insight;International;Laboratories;Lead;Light;lipidomics;Liquid substance;Measurement;Measures;Mission;molecular marker;Monitor;Nerve Degeneration;Neurodegenerative Disorders;neurofilament;neuroimaging;Neurologist;neuropathology;novel;novel marker;Nucleic Acids;Online Systems;Participant;Patients;Peripheral Blood Mononuclear Cell;Physicians;Plasma;Positioning Attribute;Privatization;Procedures;Process;Prognostic Marker;prognostication;Proteins;Proteomics;query tools;repository;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Resources;RNA;Sampling;Scientist;Serum;Specimen;Spinal Puncture;Staging;Standardization;Symptoms;synergism;tau Proteins;tau-1;Technology;Testing;therapeutic target;treatment effect;Validation;Visit;Work

PROJECT_TITLE: Biospecimens


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Chronic Liver Disease and Cirrhosis;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: BROOKLYN COLLEGE

ORG_STATE: NY

PHR: Project narrative  Maternal high-fat feeding during pregnancy and lactation predisposes the offspring to higher risk of developing non-alcoholic steatohepatitis (NASH). This project investigates the interacting effect of prenatal and postnatal choline supplementation with dietary fat on preventing the prenatal programming of NASH. This study will provide proof-of-concept evidence for a cost-effective and noninvasive prophylaxis for NASH, dissociating the maternal obesogenic environment with adverse health consequences in the offspring.

PI_NAMEs: JIANG, XINYIN  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Affect;Antioxidants;Betaine;Blood Glucose;blood glucose regulation;Characteristics;Choline;Choline Deficiency;choline supplementation;cognitive function;compare effectiveness;cost effective;Custom;Data;Development;Diet;Dietary Fats;Dissociation;DNA Methylation;emerging adult;Environment;Epigenetic Process;epigenetic regulation;Exposure to;Fatty acid glycerol esters;fatty acid supplementation;feeding;Fetal Liver;Fetus;Fibrosis;Fish Oils;Food;Fructose;Funding;Genes;Glucose Intolerance;Grant;Health;Hepatic;hepatocyte injury;High Fat Diet;high risk;improved;Inflammation;Insulin Resistance;Intake;Intervention;Joints;Lactation;lard;Lecithin;Life;lipid biosynthesis;lipid metabolism;lipidomics;Lipids;Lipoproteins;Liver;Long-Term Effects;maternal obesity;Metabolic;methyl group;Modernization;Modification;Mus;neurogenesis;nonalcoholic steatohepatitis;Nutrient;Obese Mice;Obesity;obesogenic;offspring;Oxidative Stress;Phospholipids;Plasmalogens;Play;Polyunsaturated Fatty Acids;Population;postnatal;postnatal period;Predisposition;Pregnancy;prenatal;Prevalence;prevent;Prevention;Process;promoter;prophylactic;Prophylactic treatment;protective effect;Public Health;Research;Risk Factors;risk mitigation;Role;simple steatosis;stable isotope;sugar;Supplementation;synergism;theories;Triglycerides;United States National Institutes of Health;Weaning;western diet

PROJECT_TITLE: Interaction of Choline and Fat in the Prenatal Programming of Nonalcoholic Steatohepatitis


ADMINISTERING_IC: HG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: EUGENE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF OREGON

PHR: ZFIN analyzes and curates zebrafish research data, provides support for zebrafish models of human disease, integrates links to data from other databases, and maintains and updates the zebrafish reference genome. The long term goals for ZFIN are a) to be the community database resource for the laboratory use of zebrafish, b) to develop and support integrated zebrafish genetic, genomic, developmental, and physiological information, c) to maintain the definitive reference data sets of zebrafish research information, d) to link this information extensively to corresponding data in other model organism and human databases, e) to facilitate the use of zebrafish as a model for human biology, and f) to help serve the broad needs of the biomedical research community.

PI_NAMEs: WESTERFIELD, MONTE  (contact)

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Adopted;Affect;Antisense Oligonucleotides;Articulation;Base Sequence;Behavior;Biological;Biomedical Research;Code;Communities;Computer software;Data;data access;data curation;data exchange;data management;data resource;Data Science;Data Set;Databases;Development;Disease;Elements;Evolution;FAIR principles;gene conservation;Gene Expression;gene function;Generations;Genes;Genetic;genetic analysis;Genetic Models;Genome;genome analysis;genome editing;genome resource;Genomics;Goals;Guidelines;Human;Human Biology;human disease;Human Genome;human model;improved;Individual;Industry Standard;Information Networks;Infrastructure;insight;International;knock-down;knockout gene;Laboratories;Link;meetings;Metadata;model organism;model organisms databases;Modeling;Mutate;Mutation;Nomenclature;Organism;Organogenesis;Orthologous Gene;Other Genetics;outreach;Pattern;Phenotype;Physiological;Physiology;Play;Process;Proteins;public database;Publications;Readability;Recovery;reference genome;repository;Research;Research Activity;Research Personnel;Resources;Role;Site;Societies;software systems;Software Tools;Strategic Planning;Structure;Surveys;symposium;Techniques;Technology;Time;tool;Training;Transgenic Organisms;United States National Institutes of Health;Update;user centered design;Vertebrate Biology;Vertebrates;Visualization;web site;wiki;Work;Zebrafish

PROJECT_TITLE: ZFIN: The Zebrafish Model Organism Database


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_STATE: CA

PROJECT_TERMS: Acoustics;affective neuroscience;Age;Algorithms;Alzheimer's Disease;Anatomic Models;Anatomy;Anterior;Area;Assessment tool;automated assessment;Autonomic nervous system;Basic Science;Behavior;behavioral variant frontotemporal dementia;Brain;Brain region;Cerebral Dominance;Clinical;clinical care;clinical development;Clinical Sciences;clinical translation;Clinical Trials;Cognitive;cognitive neuroscience;Communities;Data;Diagnosis;diagnostic accuracy;Differential Diagnosis;Disease;Disease Progression;Early Diagnosis;Emotional;emotional experience;Emotions;Empathy;Evaluation;Exhibits;experience;Facial Expression;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Functional disorder;Genes;Image;improved;innovation;Insula of Reil;Knowledge;Laboratories;Language;Language Tests;Left;Life;Linguistics;Maps;Measures;Methods;Modeling;Molecular;molecular pathology;Monitor;Motor;multimodality;Multivariate Analysis;Nerve Degeneration;neural;neural network;neurodegenerative phenotype;neuroimaging;neuropathology;novel strategies;Pathologic;Pathology;Patients;Perception;Persons;preservation;prevent;Primary Progressive Aphasia;Progressive Aphasias;remote assessment;Research;Semantics;Speech;standard measure;Structure;support network;Support System;Symptoms;Syndrome;System;Techniques;Technology;Theoretical model;Time;tool;treatment response;Variant;verbal;Work

PROJECT_TITLE: Language and Emotions: Discovery and Clinical Translation