ADMINISTERING_IC: IP

IC_NAME: NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE The goal of our project is to gather important data on respiratory viral illnesses in communities in the Greater Boston Area. We will study how often respiratory viral illnesses occur – like COVID-19 and influenza – and how these viruses are spread. Our goal is to improve public health interventions to prevent disease.

PI_NAMEs: STEPHENSON, KATHRYN ELAINE (contact)

PROJECT_TITLE: IP24-045, A Prospective Observational Study of Respiratory Virus Epidemiology in the Greater Boston Area

STUDY_SECTION_NAME: Special Emphasis Panel[ZIP1 GCA (63)]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: PROJECT NARRATIVE Efforts to translate the diabetes prevention program have had limited effectiveness in the low-income Latino population. To build my research skills in natural experiments, we propose to evaluate the effectiveness of a statewide policy that mandates Medicaid DPP coverage, specifically looking at the impact on low-income Latinos. To support my career development in health disparities, we will adopt a community-partnered approach to supplement these findings and design and implement a single-arm feasibility and acceptability pilot trial of a community-based intervention linking low income Latino patients with prediabetes to local resources addressing structural and community-level barriers to improve recruitment, engagement, and weight loss in the DPP at three safety-net clinics in South Los Angeles.

PI_NAMEs: CASTELLON-LOPEZ, YELBA  (contact)

PROGRAM_OFFICER_NAME: ARTIS DICKERSON, SHAVON

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Amputation;Area;arm;Award;beneficiary;Blindness;Blood Pressure;Body Weight Changes;Body Weight decreased;Budgets;California;Cardiovascular Diseases;career;career development;Caring;Centers for Disease Control and Prevention (U.S.);Clinic;Clinical;Clinical Trials;Communities;community advisory board;community barrier;community engaged approach;community engaged intervention;community intervention;community partners;Complications of Diabetes Mellitus;cost;Data;Data Analyses;Death Rate;design;Development;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;diabetes risk;Disparity;Effectiveness;effectiveness evaluation;Eligibility Determination;Epidemic;evidence base;experience;Face;Federally Qualified Health Center;Food;Future;Goals;Grant;Health;Health Disparities Research;health disparity;health equity promotion;Health Insurance;health plan;Health system;high risk;implementation barriers;implementation intervention;improved;improved outcome;Incidence;Income;Insurance Coverage;interest;Intervention;intervention program;Intervention Studies;K-Series Research Career Programs;Kidney Failure;Language;Latino;Latino Population;Laws;Learning;Life Style;Limited English Proficiency;Link;Los Angeles;Low income;Low Income Population;marginalized population;Measures;Medicaid;Medicaid eligibility;Mentors;Metformin;minority communities;minority engagement;Minority Groups;minority health disparity;Natural experiment;Neighborhood Health Center;Non-Insulin-Dependent Diabetes Mellitus;obese person;Outcome;Outcome Study;Overweight;Participant;patient oriented;Patients;personalized approach;Physical activity;Pilot Projects;pilot trial;Policies;Pragmatic clinical trial;Prediabetes syndrome;Prevalence;prevent;primary outcome;Process;programs;randomized trial;Randomized, Controlled Trials;recruit;Reporting;Research;Research Personnel;Resources;Risk;safety net;secondary outcome;skill acquisition;skills;social health determinants;Spanish;Structure;success;Techniques;Translating;United States;Vulnerable Populations;Work

PROJECT_TITLE: Understanding Barriers to Engagement in the Diabetes Prevention Program among Low-Income Latino Patients: Design and Implementation of an Intervention in Community Health Centers

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Neurodegenerative;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE This expanded access program will offer ibudilast as an experimental treatment to people with amyotrophic lateral sclerosis (ALS) – a relentlessly progressive neurodegenerative disease – by adapting electronic infrastructures. We will assess its safety and efficacy, and additionally, capture the profile of ibudilast responders through the integration of pioneering sequencing methods, thereby paving the way for individualized ALS therapies.

PI_NAMEs: OSKARSSON, BJORN E (contact)

PROGRAM_OFFICER_NAME: LYON, DINA MARIE

PROJECT_TERMS: Acceleration;Adherence;Age;ALS patients;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Anti-Inflammatory Agents;Asthma;Autophagocytosis;Biological Markers;biomarker validation;Blood;candidate marker;Cells;Central Nervous System;Cessation of life;Characteristics;Clinic;Clinical;Clinical Trials;Data;Data Set;demographics;Disease;drug development;Effectiveness;efficacy evaluation;electronic consent;Electronics;Enrollment;Ethnic Origin;Evaluation;Event;Exclusion;Exclusion Criteria;Funding;Future;Gender;Genes;Genetic;genetic variant;Genome;genome sequencing;genomic data;genomic variation;Genomics;Health;Health Services Accessibility;Home;Hospitalization;inclusion criteria;inflammatory marker;Infrastructure;Intervention Trial;Investigational Therapies;Japan;Laboratories;Laws;Life;Light;Maps;Measurement;Medical;Methods;Monitor;Motor Neuron Disease;Multiomic Data;multiple omics;Neurodegenerative Disorders;neurofilament;novel;novel marker;Online Systems;Outcome;Outcome Measure;Participant;Pathology;Pathway interactions;patient population;patient stratification;Patients;Penetration;personalized medicine;Persons;Pharmaceutical Preparations;pharmacologic;Phase II/III Trial;phosphoric diester hydrolase;Physicians;Physicians' Offices;Plasma;Population;post stroke;precision medicine;primary outcome;Process;programs;protein TDP-43;Race;Research;Resources;responders and non-responders;response;RNA;Safety;Sampling;Sea;sex;Single Nucleotide Polymorphism;Site;stroke symptom;superoxide dismutase 1;Technology;Testing;therapy development;transcriptome;transcriptome sequencing;transcriptomics;treatment response;United States;Variant;virtual;Visit;whole genome

PROJECT_TITLE: Scalable Expanded Access with Analysis of Neurofilament and Other Biomarkers for Ibudilast in ALS (SEA-NOBI-ALS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-E (07)]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: Geneva

ORG_COUNTRY: SWITZERLAND

ORG_FIPS: SZ

ORG_NAME: PHARMACEUTICAL INSPECTION CO-OPERATION SCHEME-ASSOCIATION DE DROIT SUISSE

PHR: Project Narrative The project aims at addressing the need to have, at the global level, a recognized programme for standardization of training and qualification of GMP inspectors as these harmonisation efforts are crucial to achieve a consistent interpretation and uniformed application of GMP by inspectors worldwide. This is key to mutual trust, which in turn will allow for mutual reliance between regulatory authorities. This will allow not only to maximize inspectional resources but also to strengthen the protection of public health by ensuring effective, high-quality and comparable GMP inspections for the quality of regulated API and medicinal products.

PI_NAMEs: BOCHATON, FABIENNE  (contact);BRUNNER, DANIEL ;HODGSON, JEFFREY ;HOLY, JIRI

PROGRAM_OFFICER_NAME: MAXIMO, JULIANE

PROJECT_TITLE: Strengthening Global Competency & Capacity in Inspectional Approaches through the Implementation of a Web-based Educational Centre for Pharmaceutical Inspectors Worldwide

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 OC-T (05)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Nanotechnology;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE We recently discovered that glutaminase activity is highly upregulated in activated microglia during chronic stress and that inhibiting the elevated microglial activity relieves psychosocial behavior deficits and inflammatory cytokine induction. Although our glutaminase inhibitor JHU083 showed robust therapeutic efficacy in proof-of- concept studies, its lack of selectivity and propensity to cause gastrointestinal toxicity limits its translational application. Given the significant clinical potential of this mechanism, we propose to overcome this limitation by utilizing our recently developed and highly selective glutaminase inhibitor JHU29 and directly targeting it to microglia using a hydroxyl-dendrimer nanoparticle delivery system, and to evaluate the efficacy and safety of the dendrimer-glutaminase inhibitor conjugates in established mice models of chronic stress.

PI_NAMEs: ZHU, XIAOLEI  (contact)

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: Acute;Anhedonia;Animal Model;anti-depressive agents;Autopsy;Behavior;Behavior assessment;behavior test;Biodistribution;Biological Assay;Body Weight;Brain;Brain Injuries;brain tissue;Buffers;chemical stability;Chronic;Chronic stress;Circulation;Clinical;Clinical Chemistry;Clinical Research;clinical translation;Clinical Trials;combat;Complete Blood Count;cyanine dye 5;cytokine;Data;Data Set;Dendrimers;Dose;drug discovery;Drug Kinetics;Economic Burden;effective therapy;efficacy evaluation;Enzymes;Exhibits;experience;Fluorescence Microscopy;Functional disorder;Future;gastrointestinal;Generations;glutamatergic signaling;Glutamates;Glutaminase;Glutamine;glutamine analog;Histology;Hospitalization;Human;Hydrolysis;Hydroxyl Radical;in vivo;Inflammation;Inflammatory;inhibitor;Intervention;Investigational Drugs;Ketamine;Kinetics;Label;Major Depressive Disorder;Mental Depression;Mental disorders;Methods;Microglia;Modeling;Mood Disorders;Morphology;mortality;mouse model;Mus;nanoparticle;nanoparticle delivery;neuroinflammation;Norleucine;novel;Oral;Oral Administration;Pathologic;Pathology;Patients;Peripheral;Pharmaceutical Preparations;Phase II Clinical Trials;Phenotype;Plasma;Play;Pre-Clinical Model;Prefrontal Cortex;Prevalence;Prodrugs;Production;psychosocial;Reporting;residence;Resistance;Rodent Model;Role;Safety;scale up;severe COVID-19;single nucleus RNA-sequencing;social;social defeat;Societies;Stress;System;Therapeutic;therapeutic target;Toxic effect;translational applications;translational approach;translational potential;Treatment Efficacy;Up-Regulation;uptake

PROJECT_TITLE: Microglia-targeted glutaminase inhibition forthe treatment of chronic stress-associated depression

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: 8. PROJECT NARRATIVE The Centers of Excellence in Regulatory Science and Innovation (CERSI) program allows the U.S. Food and Drug Administration (FDA) to form extramural partnerships that foster robust and innovative research to develop new tools, standards, and approaches to assess the safety, efficacy, quality, and performance of FDA- regulated products, supporting regulatory decision-making and the overall mission of the FDA. Over the past seven years, the Yale-Mayo Clinic CERSI has pursued a series of innovative research projects that leverage real-world data sources to assess the safety, efficacy, quality, and performance of FDA-regulated products, informing regulatory decision-making as well as manufacturers, clinicians, and patients in support of optimizing patient-centered care, along with providing and supporting high-quality mentorship and training in regulatory science. The Yale-Mayo Clinic CERSI will continue this work, conducting high-quality, high-impact regulatory science research in priority areas identified by the FDA to modernize development and evaluation of FDA- regulated products, strengthen post-market surveillance and labelling of FDA-regulated products, and invigorate public health preparedness and response of FDA, patients, and consumers.

PI_NAMEs: ROSS, JOSEPH SOLOMON (contact)

PROGRAM_OFFICER_NAME: BATTLES, JESSICA JOY

PROJECT_TITLE: Yale-Mayo Clinic FDA Center of Excellence in Regulatory Science and Innovation (CERSI)


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Diabetes;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Diabetes increases the risk of cognitive impairment and dementia although the underlying mechanisms remain incompletely understood. We aim to evaluate newly developed, noninvasive measures of cerebral arterial compliance and blood flow in order to determine whether early functional brain changes proceed the development of irreversible cerebrovascular lesions and cognitive decline in older adults with diabetes and non-diabetic control participants. We will also examine the role of treatable/potentially modifiable mechanisms underlying cognitive changes, with the ultimate goals of advancing our understanding of the pathogenesis of diabetes-related cognitive dysfunction and identifying individuals at risk for cognitive impairment so that interventions to reduce dementia risk can be started as early as possible in order to improve health and functioning.

PI_NAMEs: BANGEN, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Address;Affect;aged;Alzheimer's Disease;Alzheimer's disease pathology;Apolipoprotein E;arterial spin labeling;arterial stiffness;Autopsy;biomarker identification;Blood flow;Blood Pressure;Blood Vessels;blood-based biomarker;Brain;brain health;cardiometabolism;care providers;cerebral microbleeds;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular lesion;Cerebrum;clinical decision-making;Cognition;Cognitive;cognitive change;cognitive testing;comorbidity;Control Groups;Dementia;dementia risk;demographics;Development;Diabetes Mellitus;diabetes pathogenesis;Diagnosis;Disease Marker;Dose;early detection biomarkers;Early identification;executive function;Family member;Femur;follow-up;glycemic control;Glycosylated hemoglobin A;Goals;Health;Hemorrhage;Hypertension;Impaired cognition;improved;improved outcome;Individual;individualized medicine;interest;Intervention;Laboratories;Lesion;Link;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measurement;Measures;Memory;Methods;mild cognitive impairment;neuroimaging;neuropathology;Neuropsychology;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;older adult;Participant;Peripheral;Physiologic pulse;Prevalence;Prognosis;Protocols documentation;Public Health;Resolution;response;Risk;Risk Factors;Risk Marker;Role;Sampling;Site;structural imaging;targeted treatment;Technology;Testing;treatment planning;Vascular Dementia;vascular risk factor;white matter;White Matter Hyperintensity;Work

PROJECT_TITLE: Intracranial arterial compliance, cerebral blood flow, and dementia risk in older adults with type 2 diabetes

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Back Pain;Biotechnology;Chronic Pain;Genetics;Neurosciences;Pain Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Chronic back pain is a leading cause of disability worldwide and is frequently caused by damage to the inter- vertebral discs in the spine. The objective of this application is to develop and validate a preclinical model of low back pain with intervertebral disc degeneration to facilitate the discovery of non-addictive treatments for back pain.

PI_NAMEs: STONE, LAURA S (contact)

PROGRAM_OFFICER_NAME: ROOF, REBECCA

PROJECT_TERMS: Absence of pain sensation;abuse liability;addiction liability;Address;Affect;Affective;age related;aggrecan;Analgesics;Attention;Back Pain;Behavior;Behavioral;behavioral phenotyping;Biological Assay;Biological Process;Brain;brain abnormalities;Cells;Chemicals;chronic back pain;Chronic low back pain;Clinical;clinically relevant;Cognitive;Cognitive deficits;conditioned place preference;Cre-LoxP;Crossbreeding;Cysteine;Development;disability;Disease;Down-Regulation;Ensure;Eye;Eye Abnormalities;Face;Genes;Genetic Recombination;Height;Histology;Human;Human Characteristics;Ibuprofen;Impairment;improved;in utero;Individual;inducible Cre;Inflammation;Injury;Intervention;Intervertebral disc structure;intervertebral disk degeneration;Keratin-19;Low Back Pain;LoxP-flanked allele;Maps;Measures;Mechanics;Modeling;Molecular;Morphine;Motor;mouse model;mRNA Expression;Mus;nerve supply;New England;novel;novel therapeutics;nucleus pulposus;Operative Surgical Procedures;Outcome;Pain;Pain Attribute;pain model;Pathologic;Pathology;Patients;Persistent pain;pharmacologic;Phenotype;Physical therapy;Physiological;Pre-Clinical Model;pregabalin;Procedures;Process;protein expression;Protein Secretion;Protocols documentation;Radiating Pains;radiological imaging;Radiology Specialty;Reporter;Secondary to;side effect;Site;skeletal;Societies;Spinal nerve structure;Structural Protein;System;Tamoxifen;targeted treatment;Testing;Therapeutic;therapeutic development;Therapeutic Effect;Therapeutic Intervention;Thinness;Time;Tissues;Universities;Validation;Vertebral column;Visual Acuity;Work

PROJECT_TITLE: Development and Validation of a Mouse Model of Intervertebral Disc Degeneration-Induced Low Back Pain to Facilitate Non-Addictive Analgesic Discovery

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Neurosciences;Pediatric;Rare Diseases

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE: PUBLIC HEALTH RELEVANCE Cranial neural crest cells are essential for the formation of diverse craniofacial structures including bones and cartilage as well as portions of cranial ganglia; as such, defects in cranial neural crest specification, epithelial- to-mesenchymal transition, and differentiation are root to many craniofacial birth defects including craniosynestosis, Treacher Collins and CHARGE syndromes. This project will identify the mechanisms that control BMP signaling during its essential roles in cranial neural crest specification and will determine the molecular function of BMP signaling during cranial neural crest epithelial-to-mesenchymal transition. The results will provide significant and novel avenues for translational approaches to prevent and treat neural crest-derived craniofacial birth defects.

PI_NAMEs: PIACENTINO, MICHAEL LOUIS (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Binding;Biology;Body System;bone;bone morphogenetic protein receptors;California;career;Cartilage;cell type;Cells;Cephalic;CHARGE syndrome;Chick;Childhood;chromatin immunoprecipitation;Cleft Palate;Clustered Regularly Interspaced Short Palindromic Repeats;comparison control;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;craniofacial development;craniofacial disorder;craniofacial structure;Data Set;Defect;Dentin;Development;Diffusion;DiGeorge Syndrome;Ectoderm;Embryo;embryo cell;Environment;Epidermis;epithelial to mesenchymal transition;Event;experience;experimental study;extracellular;Face;Ganglia;Gastrula;gastrulation;Genes;Genetic Epistasis;Goals;Image;in silico;in vivo;in vivo Model;Individual;Inhibitor of Differentiation Proteins;Lateral;Lead;Ligands;loss of function;Mandibulofacial Dysostosis;mathematical model;Measures;Medial;Mentors;Molecular;morphogens;neural;Neural Crest;Neural Crest Cell;neural plate;novel;Pathway interactions;Peptide Hydrolases;Peripheral;Peripheral Nervous System;Phase;Play;Population;prevent;programs;public health relevance;Reaction;receptor expression;Regulation;Reporter;Research;response;Role;Signal Pathway;Signal Transduction;Skeleton;spatiotemporal;Specific qualifier value;System;Systems Biology;Technology;Testing;Therapeutic;timeline;tool;Tooth structure;Training;transcriptome sequencing;translational approach

PROJECT_TITLE: Characterizing the cranial neural crest response to BMP signaling through gastrulation and neurulation

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Rare Diseases;Telehealth

ORG_CITY: Rockville

ORG_NAME: PEDIAMETRIX INC.

PHR: NARRATIVE  Delayed identification of infant head malformation is causing unnecessary medical complications and societal costs, partly because of the absence of tools available to pediatric offices. For this Fast-track SBIR proposal, PediaMetrix Inc. has joined forces with clinical institutions to develop and evaluate a 3D mobile scanning tool that provides cranial volume and malformation measurements. Our tool, called SoftSpotTM, will improve the early detection and management of infant cranial malformations at the point-of-care and avoid delayed, costly and intensive treatments.

PI_NAMEs: AALAMIFAR, FERESHTEH  (contact);SEIFABADI, REZA

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: 3-Dimensional;Address;Affect;Algorithms;Attention;Auditory Perceptual Disorders;Brain;Cellular Phone;Cephalic;Cephalometry;Child;Childhood;Classification;Clinical;commercialization;Complex;cost;Craniosynostosis;cranium;Data;Data Analyses;Data Collection;deep learning model;Deformity;design;Detection;Development;Diagnosis;digital health;digital tool;Early Diagnosis;Early treatment;effective therapy;Epidemic;Evaluation;experience;Feasibility Studies;Growth;Head;Head circumference;Health;Health Care Costs;Health Personnel;Health Professional;Helmet;Home;Image;Impairment;improved;indexing;infancy;Infant;infant monitoring;Institution;Intracranial Hypertension;Investigation;Left;Location;Machine Learning;machine learning method;malformation;Mandible;Measurement;Measures;medical complication;Methods;mHealth;millimeter;Mission;mobile application;mobile computing;Mobile Health Application;Monitor;Morbidity - disease rate;Motion;new technology;Operative Surgical Procedures;Patients;Pediatric Hospitals;pediatrician;Pediatrics;Penetration;Phase;Physical therapy;plagiocephaly;point of care;Positioning Attribute;Prevalence;prevent;prototype;quantitative imaging;reconstruction;Reporting;research clinical testing;Scanning;screening;sensor;shape analysis;Shapes;Site;Small Business Innovation Research Grant;smartphone application;social anxiety;societal costs;Standardization;Structure;support tools;Technology;Time;tool;Torticollis;Training;usability;user-friendly;Visit;Well Child Visits;Work

PROJECT_TITLE: Mobile Three-Dimensional Screening for Cranial Malformations


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biotechnology;Cardiovascular;Congenital Heart Disease;Genetics;Heart Disease;Pediatric;Rare Diseases;Regenerative Medicine;Transplantation

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PUBLIC HEALTH NARRATIVE Congenital cardiac anomalies represent the most common birth defect, affecting nearly 1% of all live births. Despite significant advances in surgical and medical management, these conditions remain a leading cause of death and disability in the newborn period. One significant source of morbidity and mortality arises from complications associated with the use of currently available prosthetic vascular grafts, cardiovascular patches, and replacement heart valves that are frequently required to perform reconstructive procedures. Tissue engineering offers a potential strategy for creating improved biomaterials for use in congenital heart surgery. In this project, we will elucidate the mechanism underlying LYST-mediated TEVG stenosis, the most common graft-related complication and the critical barrier preventing its widespread clinical use.

PI_NAMEs: BREUER, CHRISTOPHER KANE (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: Affect;Autologous;Automobile Driving;Biocompatible Materials;Blood Vessel Prosthesis;Blood Vessels;Cardiovascular system;Cause of Death;Cell Physiology;cell type;Cells;Child;CHS1 gene;Clinical;Clinical Research;Clinical Trials;Code;Complication;Computer Models;Congenital Abnormality;congenital heart abnormality;Congenital Heart Surgery;cost;critical period;design;Development;disability;Endosomes;Endothelial Cells;extracellular vesicles;functional restoration;genetic regulatory protein;Goals;graft function;Growth;heart valve replacement;Immune;Immune response;immunoregulation;Immunosuppression;Implant;implantation;improved;improved outcome;In Vitro;in vivo;Incidence;Infiltration;Inflammation;Live Birth;Macrophage;man;Mediating;Medical;Messenger RNA;MicroRNAs;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Newborn Infant;next generation;novel;operation;Operative Surgical Procedures;Paracrine Communication;Postoperative Period;prevent;Procedures;Process;Production;Proteins;Public Health;rational design;Regulator Genes;repaired;Role;Safety;scaffold;Serious Adverse Event;Signal Transduction;Smooth Muscle Myocytes;Source;Stenosis;Surgical complication;System;Tamoxifen;Therapeutic;Tissue Engineering;Tissues;Transgenic Organisms;Tubular formation;Vascular Graft;vascular tissue engineering;Vesicle;Wild Type Mouse

PROJECT_TITLE: Elucidating the Molecular Mechanisms Underlying LYST-mediated Tissue Engineered Vascular Graft Stenosis

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Precision Medicine;Prevention;Rehabilitation;Substance Misuse

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative  Anxiety and anxiety-related disorders frequently co-occur with alcohol use problems resulting in an enormous humanitarian and economic cost to society. The proposed research will use digital technology to examine person-specific risk factors predicting problematic alcohol use in individuals vulnerable to anxiety and anxiety-related disorders and will use this information to design a personalized intervention for individuals seeking psychological treatment. Results from this research will integrate output from novel and innovative digital technology methods into psychotherapy, advancing research on personalized treatment and prevention efforts.

PI_NAMEs: PICCIRILLO, MARILYN  (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: Accelerometer;Adult;Alcohol abuse;alcohol abuse therapy;alcohol comorbidity;Alcohol consumption;alcohol effect;alcohol misuse;alcohol relapse;alcohol research;alcohol risk;alcohol use disorder;Anxiety;anxiety-related disorders;Award;Behavior;Behavior Therapy;Behavioral;Bluetooth;career;Cellular Phone;Cessation of life;Cognitive Therapy;comparison intervention;Conduct Clinical Trials;coping;cost;craving;Data;Data Collection;data streams;design;Development;digital phenotyping;digital technology;disability;Distress;dual diagnosis;Ecological momentary assessment;economic cost;efficacy testing;Evaluation;Exhibits;feasibility testing;Feedback;Future;Health Care Costs;Heterogeneity;improved;Individual;individualized prevention;Influentials;innovation;Intervention;intervention effect;Mental Depression;Mental Health;Methods;Modeling;multilevel analysis;negative affect;negative emotional state;novel;Numbness;Outcome;Output;Pattern;personalized intervention;personalized medicine;Persons;Phase;phenotypic data;Post-Traumatic Stress Disorders;Predictive Factor;premature;Process;psychologic;Psychopathology;Psychotherapy;Randomized;randomized, clinical trials;Randomized, Controlled Trials;rate of change;reduce symptoms;reduced alcohol use;Research;Research Personnel;Risk Factors;Role;Self Medication;skills;Social Anxiety Disorder;Societies;Statistical Data Interpretation;Statistical Models;Substance Use Disorder;success;Suicide attempt;Symptoms;Testing;Therapeutic;Therapeutic Intervention;Time;Training;Treatment Efficacy;Vulnerable Populations;Work

PROJECT_TITLE: Digital Phenotyping of Anxiety and Anxiety-Related Alcohol Comorbidity and Treatment


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Muscular Dystrophy;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Muscular Dystrophy is a lethal muscle wasting disease with no cure or effective treatment. This proposal will study important mechanistic details about how myofiber cell death occurs in dystrophic muscles and measure the total contribution of necrotic cell death in dystrophic disease. The outcome of this proposal will aid in defining new therapeutic targets to treat Muscular Dystrophy.

PI_NAMEs: BROUND, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Ablation;Acute;Adenine Nucleotides;Adenosine;Ants;Area;Calcium;Cell Death;Cell Membrane Permeability;Cessation of life;Complex;cyclophilin D;Development;Disease;Disease Progression;Duchenne muscular dystrophy;Dystrophin;effective therapy;Exhibits;family genetics;Functional disorder;gene therapy;Genes;Genetic;Genetic Diseases;Goals;Heart;Homeostasis;inhibitor;insight;Knock-out;Knockout Mice;Limb-Girdle Muscular Dystrophies;mdx mouse;Measures;Membrane;membrane model;Mitochondria;mitochondrial membrane;Modeling;Molecular;Molecular Target;mouse model;Mus;Muscle;Muscle function;Muscle Mitochondria;Muscular Atrophy;Muscular Dystrophies;Myocardial Ischemia;Myopathy;Necrosis;new therapeutic target;novel;novel strategies;Nucleotides;Outcome;Pathology;Physiological;premature;prevent;Process;Protein Family;Protein Isoforms;Proteins;Publishing;Regulation;Reperfusion Injury;Research;Role;Rupture;Sarcolemma;Skeletal Muscle;SLC25A4 gene;SLC25A5 gene;System;targeted treatment;Testing;Up-Regulation;uptake;Wasting Syndrome;Work

PROJECT_TITLE: Mitochondrial Regulation of Calcium Homeostasis and Cell Death in Muscular Dystrophy


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Resilience interventions are a promising strategy to improve individuals’ mental health and well-being; however, emerging models too often rely on time and resource intensive in-person trainings tested with still largely preliminary research designs limiting confidence in their scalability and impact. This project will use a rigorous clustered randomized controlled efficacy trial to test a fully remotely delivered resilience intervention targeting childcare staff, a high-risk group of essential workers. Results will provide guidance for a scientifically sound, replicable resilience intervention that can be rapidly translated to workplaces that are chronically affected by structural inequities.

PI_NAMEs: HALES, DEREK ;JONES, DEBORAH J (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: Address;Adoption;Affect;Aftercare;Age;arm;Attention;attentional control;Awareness;care providers;Child Care;Chronic;Clinical Trials;Control Groups;Data;design;Education;efficacy evaluation;efficacy testing;efficacy trial;Electronic Mail;Employee;Enrollment;Essential worker;Exposure to;Focus Groups;follow-up;food insecurity;Health;Health Promotion;high risk;high risk population;Hour;improved;Individual;Inequity;interest;Intervention;intervention effect;Learning;Literature;Low income;Maintenance;marginalization;Measures;Mental Depression;Mental Health;mHealth;Minority;Modeling;novel;online delivery;Online Systems;Outcome;pandemic disease;Participant;Personal Satisfaction;Persons;Phase;Population;Population Heterogeneity;post intervention;primary outcome;programs;Public Assistance;Race;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;remote delivery;Research;Research Design;resilience;resilience scale;Resources;Risk;Sample Size;Sampling;satisfaction;Science;secondary outcome;social health determinants;Social support;sociodemographics;sound;stress management;stress resilience;stressor;Testing;Text;Therapeutic;Time;Training;Training Programs;Translating;Translations;treatment effect;Underserved Population;usability;web-based intervention;webinar;Wellness Program;Work;Workplace

PROJECT_TITLE: A Cluster-Randomized Control Trial of a Workplace Resilience Intervention for Child Care Providers' Mental Health & Well-Being

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 MQ (01)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention;Substance Misuse

ORG_CITY: NORTH CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI

ORG_STATE: IL

PHR: PROJECT NARRATIVE HIV infection often causes many brain disorders and affects the ability of people to care for themselves, and thus, the quality of their daily life. The social and economic impact cannot be overemphasized. The current study seeks to better understand HIV-associated neurocognitive disorders that have become more prevalent in the era of antiviral therapy and then use the knowledge acquired to develop new therapeutics to help treat these devastating conditions.

PI_NAMEs: HE, JOHNNY J (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Abbreviations;Affect;Agonist;alpha-bungarotoxin receptor;Anti-Inflammatory Agents;Anti-Retroviral Agents;Anti-viral Therapy;antiretroviral therapy;Astrocytes;Binding;Biochemical;Brain;Brain Diseases;Caring;Cell Nucleus;Cells;Central Nervous System;Central Nervous System Infections;Choline;cholinergic;Chronic;Cognitive;cognitive function;cost;Disease;disease model;DLG4 gene;Doxycycline;economic impact;Functional disorder;genetic approach;Genetic Transcription;Genomics;glial activation;Goals;Hippocampus;HIV;HIV Envelope Protein gp120;HIV Infections;HIV tat Protein;HIV therapy;HIV-associated neurocognitive disorder;Human;Immune;immune function;Impairment;improved;in vivo;Individual;Injury;Intervention;Knockout Mice;Knowledge acquisition;Learning;Life;life span;MAP Kinase Gene;Mediating;Memory impairment;Microglia;Minor;Modeling;Molecular;motor disorder;mouse model;Mus;Nervous System Disorder;Neurocognitive;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurologic;Neurology;Neurons;Neuropathogenesis;neuropathology;neuroprotection;neurotoxic;neurotoxicity;neurotransmission;Nicotinic Agonists;Nicotinic Receptors;novel therapeutics;p38 MAPK Signaling Pathway;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathway interactions;Penetrance;Performance at work;Persons;positive allosteric modulator;Positive Transcriptional Elongation Factor B;pre-clinical;prevent;Property;Regimen;Regulation;Role;Social Impacts;systemic inflammatory response;tat Protein;Technology;Testing;Therapeutic;Therapeutic Agents;Transgenic Mice;Treatment-related toxicity;Up-Regulation;Virulence Factors

PROJECT_TITLE: Positive allosteric modulator PNU-120596 to treat HIV-associated neurocognitive disorders

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR/STTR CONTRACTS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Rare Diseases

ORG_CITY: TALLAHASSEE

ORG_NAME: INSILICOM, LLC

PI_NAMEs: ZHANG, JINFENG  (contact)

PROJECT_TERMS: Acceleration;Address;Adverse effects;Affect;Algorithms;Award;Biological;Biological Process;Businesses;Cancer cell line;cancer therapy;candidate identification;candidate selection;Cell Line;clinical practice;Collaborations;Combined Modality Therapy;data integration;Data Set;design;Development;Disease;drug candidate;drug repurposing;Drug Targeting;effective therapy;efficacy evaluation;Ensure;Family;Genes;genomic data;Health;Human;Individual;Information Retrieval;insight;Investigation;knowledge graph;Label;Laboratories;machine learning model;Malignant Neoplasms;Manuals;model building;Modeling;Natural Language Processing;Nature;novel;Outcome;Pharmaceutical Preparations;predictive modeling;Probability;Processed Genes;programs;public database;PubMed;rare cancer;Research;Safety;Semantics;Small Business Innovation Research Grant;Statistical Methods;Techniques;technological innovation;Technology;Testing;Text;tool;Treatment Efficacy;United States National Institutes of Health;Validation

PROJECT_TITLE: SBIR FY24 CONCEPT AWARD-DRUG REPURPOSING FOR RARE CANCERS USING A LARGE-SCALE, HIGH-QUALITY BIOMEDICAL KNOWLEDGE GRAPH


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative This study will combine eight data sources on lifecourse social and vascular risk factors for Alzheimer’s Disease and Related Dementias (ADRD) to create a large (N=304,171) and diverse (25% Black) synthetic birth cohort (age 0 to 90) for research on ADRD. We will apply rigorous methods to estimate and incorporate corrections for selection forces, including survival, enrollment, attrition, and reverse causation from incipient dementia to risk factor changes. The synthetic cohort will then be used to rigorously estimate how lifecourse social and vascular factors and hypothetical age-specific interventions on those risk factors would affect ADRD risk and ADRD disparities.

PI_NAMEs: GLYMOUR, MEDELLENA MARIA;ZEKI AL HAZZOURI, ADINA  (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Address;Adolescent;Adopted;Adult;Affect;African American population;Age;age related;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;Attenuated;biological sex;Birth;Black American;Black Populations;Black race;Blood Vessels;Body Weight decreased;caucasian American;Child;Childhood;cohort;Cohort Studies;Coronary artery;cost;Data;Data Collection;Data Set;Data Sources;Dedications;Dementia;dementia burden;dementia risk;Development;Diagnosis;Disparity;emerging adult;Enrollment;Etiology;Evaluation;Face;Genetic Risk;geographic disparity;Goals;Health;Health and Retirement Study;Heart;high risk;human old age (65+);Impaired cognition;improved;Individual;Intervention;late life;Lead;Life;Life Cycle Stages;Longitudinal Studies;men;Mendelian randomization;Methodology;Methods;middle age;Modeling;multiple data sources;National Health and Nutrition Examination Survey;National Longitudinal Survey of Adolescent to Adult Health;National Longitudinal Survey of Youth;nutrition;Obesity;older adult;Pattern;Phase;Positioning Attribute;prevent;Prevention;Process;protective factors;Public Health;racial disparity;Research;research study;Risk;Risk Factors;Role;Sampling;social;social factors;socioeconomic disadvantage;Socioeconomic Factors;Stroke;Structure;Time;tool;vascular factor;vascular risk factor;Walking;Woman;young adult

PROJECT_TITLE: Building an unbiased pooled cohort for the study of lifecourse social and vascular determinants of Alzheimer's Disease and Related Disorders

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Pediatric

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PI_NAMEs: ESPINOSA, JOAQUIN M. (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Acceleration;Adult;advocacy organizations;Advocate;Affect;Alzheimer's Disease;Area;Atherosclerosis;autism spectrum disorder;Autoimmune Diseases;Caring;Clinical;Clinical Trials;cohort;Cohort Studies;Collaborations;Collection;Communication;Communities;Congenital Heart Defects;Cultural Backgrounds;Data Analyses;data management;Data Set;data sharing;demographics;Development;Diet;disability risk;Down's Syndrome;Enrollment;Ensure;Epigenetic Process;Epilepsy;equity, diversity, and inclusion;Ethnic Origin;Evolution;experience;extend lifespan;Family;Functional disorder;gastrointestinal;General Population;Genetic;Genetic Diseases;Goals;Growth;Health;hearing impairment;Hematological Disease;high risk;high standard;Hypertension;improved;Individual;Infection;Information Technology;Intellectual functioning disability;Investigation;Life Expectancy;life span;malformation;Malignant Neoplasms;Medical;Modernization;multidisciplinary;multiple omics;Nerve Degeneration;Neurobiology;Newborn Infant;Obstructive Sleep Apnea;open data;Outcome;outreach;Ownership;Pathology;patient registry;Patient Self-Report;Personal Satisfaction;Persons;Pharmaceutical Preparations;Population;Population Study;Professional Organizations;Quality of life;Race;Recording of previous events;Registries;Research;Research Personnel;Resources;Secure;sex;Societies;Socioeconomic Status;Solid;United States National Institutes of Health;Visual impairment

PROJECT_TITLE: Down Syndrome Connect Registry


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Prevention;Serious Mental Illness;Suicide;Suicide Prevention

ORG_CITY: BURLINGAME

ORG_NAME: MAGNUS MEDICAL INC

PHR: PROJECT NARRATIVE We recently developed a form of neuromodulation termed SAINT that induces remission in 90% of individuals with treatment-resistant depression. SAINT-induced remission is associated with significant reductions in explicit suicidal cognition. This project aims to elucidate the nature of the suicidal cognition changes produced by applying SAINT to the DLPFC-sgACC of acutely suicidal inpatients.

PI_NAMEs: BENTZLEY, BRANDON S (contact);WILLIAMS, NOLAN R.

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Acceleration;Acute;Admission activity;Anhedonia;Anterior;anti-depressive agents;antidepressant effect;attenuation;Brain;cingulate cortex;Cognition;Cognitive;Combined Modality Therapy;Coupled;Data;Depressed mood;depressive symptoms;design;Development;efficacy evaluation;efficacy testing;Electroconvulsive Therapy;Eligibility Determination;FDA approved;Feeling hopeless;Feeling suicidal;Future;Hospitalization;implementation intervention;Implicit Association Test;improved;indexing;Individual;innovation;inpatient psychiatric treatment;Inpatients;Intervention;Ketamine;Learning;Left;Length;Mediator;Mental Depression;Methods;modifiable risk;Moods;Nature;neural circuit;neural network;Neurobiology;neuroregulation;novel;Outcome;Outpatients;Participant;Patients;Pattern;Physiologic pulse;Pilot Projects;Prefrontal Cortex;preservation;prospective;Protocols documentation;psychiatric emergency;psychiatric inpatient;Psychiatric therapeutic procedure;Publishing;randomized trial;Randomized, Controlled Trials;reducing suicide;Remission Induction Therapy;repetitive transcranial magnetic stimulation;Rest;Safety;Schedule;side effect;Signal Transduction;social stigma;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;Sum;symptom treatment;symptomatic improvement;theories;Therapeutic;Therapeutic Effect;Time;treatment-resistant depression

PROJECT_TITLE: The Effects of Stanford Accelerated Intelligent Neuromodulation Therapy on Explicit and Implicit Suicidal Cognition


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Hypertension;Neurosciences;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Sleep and circadian disruption are common, particularly among disadvantaged populations, and have significant consequences for our cardiovascular health. The overall objective of the proposed study is to determine which sleep and circadian factors contribute to behavioral and biological markers of cardiovascular disease risk, and whether this differs by individual and community-level social determinants of health. A better understanding of the sleep-cardiovascular risk relationship across different levels of influence will help in the future design of multi-level sleep interventions to lower cardiovascular disease risk in populations most affected.

PI_NAMEs: THOMAS, STEPHEN J (contact)

PROGRAM_OFFICER_NAME: TATAW-AYUKETAH, GLADYS OROCK

PROJECT_TERMS: Address;Adult;Affect;Alcohol consumption;Area;Arrhythmia;associated symptom;Behavioral;Behavioral Medicine;Biological;Biological Markers;Black race;Blood Pressure;Blood Pressure Monitors;Body Temperature;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career;career development;circadian;Circadian Dysregulation;Collaborations;Communities;community-level factor;coronary artery calcification;Coronary heart disease;Data;design;Detection;Development Plans;Diabetes Mellitus;Diet;Disadvantaged;disease disparity;Disparity;Disparity population;Doctor of Philosophy;Echocardiography;Economics;Ethnic Origin;Ethnic Population;Event;Exhibits;Extramural Activities;feasibility testing;Female;Foundations;Funding;Future;Goals;Health;health disparity;Heart failure;High Prevalence;high risk;Hispanic;Hour;Hydrocortisone;Hypertension;improved;Incidence;indexing;Individual;infancy;Intervention;Knowledge;Left Ventricular Mass;Literature;Los Angeles;Measurement;Measures;Melatonin;Mendelian randomization;Mentorship;Methodology;Morbidity - disease rate;mortality;Myocardial Infarction;National Heart, Lung, and Blood Institute;New York;Not Hispanic or Latino;Obesity;Organ;Participant;Phase;Physical activity;poor sleep;Population;Population Heterogeneity;preference;Principal Investigator;Protocols documentation;psychologic;Race;racial population;Research;Research Personnel;Risk;Risk Factors;Role;Salivary;Science;Site;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep health;sleep quality;Sleeplessness;Smoking;social;social health determinants;Symptoms;Time;Training;Translating;Underinsured;Unemployment;United States

PROJECT_TITLE: Sleep and Circadian Contributions to Nighttime Blood Pressure Rhythms (SCN-BP)

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: PISCATAWAY

ORG_DEPT: GENETICS

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: Project Narrative Autosomal dominant polycystic kidney disease (ADPKD) is affects 1/400-1/1000 and is caused mutations in PKD1 and PKD2, which encode polycystin proteins. This competing renewal application will uncover the functions of the polycystins on cilia and tiny extracellular vesicles. Our studies will provide insight about the biology of normal and pathological processes that require or are modulated by extracellular vesicles including ADPKD.

PI_NAMEs: BARR, MAUREEN M (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Address;Affect;Afferent Neurons;Animal Communication;Animals;Architecture;Attenuated;Autosomal Dominant Polycystic Kidney;base;Biochemical;Biogenesis;Biological Markers;Biological Process;Biology;Biotin;Caenorhabditis elegans;Cell Physiology;cell type;Cilia;ciliopathy;Cloning;combat;Defect;delivery vehicle;Deposition;design;Disease;Engineering;Enzymes;extracellular vesicles;gene product;Genes;Genetic;Goals;Grant;Hermaphroditism;in vivo;insight;intercellular communication;Kidney;Kidney Diseases;Label;Life;Ligase;Location;male;Mammals;Mechanical Stimulation;Medical;model organism;Modeling;Molecular;Mutation;Nematoda;Neuroglia;Neurons;novel;parent grant;Partner in relationship;Pathologic Processes;Pathway interactions;PKD2 protein;Play;polycystic kidney disease 1 protein;protein function;Proteins;Proteome;real-time images;Reporter;Role;Sensory;Signal Pathway;Signal Transduction;Site;Sorting;System;Testing;therapeutic target;ultra high resolution;urinary;Vulva

PROJECT_TITLE: Polycystins, cilia, and extracellular vesicles in C. elegans

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

PHR: Project Narrative Genomic instability underlies many human diseases. This project will investigate the role of the conserved HELLS ATP dependent chromatin remodelers in regulation of DNA repair and genome stability. Understanding chromatin-based regulation of genome stability is critically important to advance understanding of the molecular events leading to genome instability, and ultimately to facilitate development of new approaches in disease prevention, diagnosis and treatment.

PI_NAMEs: CZAJA, WIOLETTA  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Administrative Supplement;Alkylating Agents;Alkylation;Area;base;Biological Assay;Cause of Death;Cell Death;Cell Survival;Cells;Centromere;Chromatin;chromatin remodeling;Chromosomal Breaks;Chromosomal Rearrangement;Chromosome abnormality;Cytoprotection;Data;Development;Diagnosis;Disease;disorder prevention;DNA;DNA Alkylation;DNA Damage;DNA Methylation;DNA Repair;DNA Repair Pathway;DNA replication fork;epigenomics;Etiology;Eukaryota;Event;Exhibits;Exposure to;Gametogenesis;Genetic;Genome;Genome Stability;genome-wide;Genomic approach;Genomic Instability;genomic locus;Genomics;Genotoxic Stress;Goals;HELLS gene;Heterochromatin;Human;human disease;Hypersensitivity;Immune system;immunodeficiency;immunodeficiency-centromeric instability-facial anomalies syndrome;Immunofluorescence Immunologic;Immunologic Deficiency Syndromes;insight;Knowledge;Link;Maintenance;Malignant Neoplasms;Measures;Mediating;member;Metabolism;model organism;Modeling;Molecular;Mus;Mutagens;mutant;Mutation;Neurospora;Neurospora crassa;Nonhomologous DNA End Joining;novel;novel strategies;Organism;Pathway interactions;Phenotype;Play;prevent;Proteins;Proteomics;Regulation;repaired;Reporter;Research;response;Role;Toxic effect

PROJECT_TITLE: Administrative Supplement: Role of HELLS chromatin remodeler in genome maintenance

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Coronaviruses;Dementia;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Physical Activity;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW ORLEANS

ORG_DEPT: NEUROSURGERY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE The development of cognitive deficits seen in vascular dementia (VaD) and COVID-19 is poorly understood and lacks effective treatments. As both conditions have several overlapping factors, α5β1 integrin stands out as a key mechanistic variable. Here, we propose to investigate a novel mechanism by which increased expression of integrin α5β1, a receptor that we have implicated in both VaD and COVID-19, precedes cognitive decline and can act as a therapeutic target.

PI_NAMEs: BIX, GREGORY JAYE (contact);BURANDA, TIONE

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: 2019-nCoV;abeta accumulation;Age;age related;age related changes;Age related pathologies;Amyloid beta-Protein;Bilateral;Binding;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;Brain;Carotid Stenosis;Cerebrovascular system;Chronic;Cognition;Cognitive deficits;cognitive function;Combined Modality Therapy;COVID-19;Data;Development;effective therapy;Elements;Exercise;Failure;Female;Fibronectins;Impaired cognition;improved;Inflammation;Injections;Integrin alpha5beta1;Integrins;Interleukin-6;Ischemia;male;Measurement;Measures;Methods;Modeling;morris water maze;Motor;Mus;NF-kappa B;novel;object recognition;occludin;Outcome;parent grant;Pathology;Peptides;Physiology;prevent;Progressive Disease;receptor;Rod;Role;sedentary;Specific qualifier value;Symptoms;Testing;Therapeutic;therapeutic target;Time;TNF gene;treatment group;Vascular Dementia;Western Blotting

PROJECT_TITLE: Investigating the role of Alpha5Beta1 integrin in cognitive dysfunction


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care;Suicide;Suicide Prevention

ORG_CITY: EUGENE

ORG_NAME: KSANA HEALTH, INC.

ORG_STATE: OR

PHR: PROJECT NARRATIVE  Despite efforts to prevent suicide, US rates are climbing, and suicide is the second leading cause of death amongst youth. Digital tools, especially personal smartphones, are promising avenues to address these issues and can be used to provide a unique understanding of proximal risk factors, including psychological distress, anhedonia and behavioral withdrawal, and sleep disturbance amongst high-risk individuals. This Fast-Track SBIR proposal will enhance the effectiveness of the delivery of preventative health care to youth at risk for suicide by developing and testing a comprehensive digital platform that allows practitioners to integrate objective mobile sensing and HIPAA compliant client communication tools into their management of these young people.

PI_NAMEs: ALLEN, NICHOLAS B (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Address;Adherence;Adoption;Anhedonia;Behavioral;Cause of Death;Cellular Phone;Client;Clinical Services;Communication Tools;Continuity of Patient Care;Data;Development;digital;digital platform;digital tool;Effectiveness;effectiveness clinical trial;feasibility trial;health care service organization;Health Insurance Portability and Accountability Act;high risk;high risk population;implementation fidelity;implementation framework;improved;indicated prevention;Mental Health Services;Methods;mobile sensing;outpatient programs;Outpatients;Patients;Persons;Phase;Pragmatic clinical trial;Preventive healthcare;preventive intervention;psychological distress;reducing suicide;Risk Factors;Risk Reduction;selective prevention;service delivery;Sleep disturbances;Small Business Innovation Research Grant;suicidal risk;Suicide;Suicide prevention;System;Testing;tool;user centered design;Withdrawal;Youth

PROJECT_TITLE: Development and testing of a digitally assisted risk reduction platform for youth at high risk for suicide


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative The proposed studies will investigate brain imaging markers of the locus coeruleus, a key brain region underpinning cognitive function impacted very early in Alzheimer’s disease, and will determined whether locus coeruleus markers are predictive of Alzheimer’s disease, cerebrovascular disease and cognitive decline in older adults.

PI_NAMEs: BONDI, MARK W;MATHER, MARA ;NATION, DANIEL A (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Adrenergic Agents;African American;Age;Alzheimer's Disease;American;Amyloid;apolipoprotein E-4;Asian Americans;Astrocytes;autosomal dominant Alzheimer's disease;Black race;Blood Vessels;Brain imaging;Brain region;Brain Stem;caucasian American;Cell Nucleus;Cells;cerebrovascular;Cerebrovascular Disorders;Cerebrum;Clinical;Cognition;Cognitive;cognitive function;cohort;Collaborations;Cross-Sectional Studies;Dementia;dementia risk;demographics;Disease Progression;Early Intervention;Education;Environment;ethnic diversity;Ethnic Population;experience;follow-up;Genetic;genetic risk factor;Geography;Goals;healthy aging;Hemorrhage;imaging biomarker;Impaired cognition;innovation;Institution;Intervention;Knowledge;Late Onset Alzheimer Disease;Latinx;Lesion;Link;locus ceruleus structure;Longitudinal Studies;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Medial;Memory;Methods;mild cognitive impairment;multimodality;Nerve Degeneration;Neurons;neuropathology;Neuropsychology;Non-linear Models;Norepinephrine;older adult;Outcome;Participant;Pathologic;Perfusion;Plasma;Play;Positioning Attribute;pre-clinical;predictive marker;Predictive Value;Protocols documentation;racial diversity;racial population;Research Personnel;Resources;Risk;Role;Sampling;selective attention;sex;Signal Transduction;Site;Source;Stimulus;Structure;synucleinopathy;tau mutation;tau Proteins;Tauopathies;Thick;Time;Vascular Diseases;vascular factor;vascular risk factor;white matter

PROJECT_TITLE: Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive Decline


ORG_CITY: LA JOLLA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE “PREVENT: Preparedness through Respiratory Virus Epidemiology and Community Engagement” proposes to participate in Components A1, A2, and B of the CDC Pandemic Preparedness Network by enrolling and retaining a diverse longitudinal community cohort of 2,000 individuals for collection of longitudinal symptom screening, respiratory pathogen testing and sequencing, assessment of immunity, and case-ascertained tracking of transmission. PREVENT also proposes to serve as the Data Hub for all nine CDC Pandemic Preparedness Network cohorts that will provide real-time publicly accessible data on incidence of the most common respiratory infections. Results from this project will provide information on risk factors, incidence, clinical courses, and impacts of important respiratory pathogens, that can be used for individual, institutional, and public health infection risk and infectious disease management.

PI_NAMEs: LAURENT, LOUISE CHANG (contact)

PROJECT_TITLE: IP24-045, PREVENT: Preparedness through Respiratory Virus Epidemiology and Community Engagement


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Heart Disease

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE  Heart failure affects 6.5 million individuals in the US and recent cardiovascular outcome trials (CVOTs) have demonstrated that SGLT2 inhibitors reduce hospitalization for heart failure (HHF) and cardiovascular mortality. SGLT2 inhibitors consistently increase the plasma ketone concentration and ketones are avidly taken up and metabolized by muscle to generate ATP. In the present grant we will examine the effect of exogenous ketone infusion, as well as the SGLT2i-induced rise in plasma ketone concentration, on skeletal and cardiac metabolism and on myocardial function and blood flow.

PI_NAMEs: DEFRONZO, RALPH A (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: acipimox;Affect;beta-Hydroxybutyrate;Blood flow;Butyrates;cardiac magnetic resonance imaging;Cardiovascular system;Deoxyglucose;design;Diabetes Mellitus;diabetic patient;Disease;Fatty Acids;Glucose;glucose uptake;Grant;Heart;Heart failure;heart failure with reduced ejection fraction;heart metabolism;Hospitalization;Individual;Infusion procedures;inhibitor;inhibitor therapy;Ketones;Left;Lipolysis;Metabolic;mortality;Muscle;muscle metabolism;Myocardial;Myocardium;New York;Outcome;Oxygen;Pharmaceutical Preparations;pharmacologic;Physiological;Placebos;Plasma;Positron-Emission Tomography;Protocols documentation;Risk;skeletal;Skeletal Muscle;Type 2 diabetic;uptake;Ventricular;Water

PROJECT_TITLE: Ketones, Muscle Metabolism, and SGLT2 Inhibitors

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Substance Misuse;Substance Misuse Prevention

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE The U.S. is in the midst of a grim opioid crisis, with older adolescents and young adults experiencing high rates of opioid misuse, addiction, and mortality. But because we have only scarce data on what types of prevention programs are proven to work with older adolescents and young adults, coordinated research is required to successfully adapt existing prevention programs or develop new interventions. As the Coordinating Center, RTI will support the HEAL Prevention Collaborative (HPC) to develop scientifically rigorous interventions and enable widespread adoption of positively evaluated HPC interventions for these at-risk populations.

PI_NAMEs: GRAHAM, PHILLIP W (contact)

PROGRAM_OFFICER_NAME: GOLDSTEIN, AMY B

PROJECT_TERMS: addiction;Address;Adolescent and Young Adult;Adoption;budget impact;Collaborations;Collection;Communication;comparative;Complex;computer infrastructure;Consensus;Consultations;cost effectiveness;cost estimate;Criminal Justice;Data;Data Analyses;Data Collection;data collection site;data harmonization;data integration;data management;Data Pooling;data sharing;Development;diverse data;economic evaluation;economic impact;Economics;Ensure;Etiology;evidence base;Evidence based intervention;experience;Fostering;Health;Healthcare;Helping to End Addiction Long-term;implementation framework;implementation intervention;implementation science;Infrastructure;Intervention;Knowledge;Leadership;Life Cycle Stages;Methodology;models and simulation;mortality;National Institute of Drug Abuse;Opiate Addiction;opioid abuse prevention;opioid epidemic;opioid misuse;opioid use disorder;Outcome;Policies;Population;Populations at Risk;prevent;Prevention;Prevention program;Prevention strategy;preventive intervention;Principal Investigator;Privatization;Procedures;Process;Program Evaluation;Recurrence;Research;Research Design;Research Personnel;Research Project Grants;Science;service intervention;Site;skills;systematic review;United States;web site;Work

PROJECT_TITLE: HEAL Initiative: Coordinating Center to Support NIDA Preventing Opioid Use Disorder in Older Adolescents and Young Adults


ORG_CITY: UNIVERSITY PARK

ORG_DEPT: CHEMISTRY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE Molecular chaperones maintain protein homeostasis in cells by facilitating protein folding, translocation, and degradation. They exist in multiprotein complexes to regulate cellular processes such as cell signaling, DNA repair, and more recently, cell metabolism. The proposed studies aim to understand how these chaperone complexes recruit and act on metabolic enzymes to meet the increased demand brought on by reprogramming events that contribute to human disease progression.

PI_NAMEs: PEDLEY, ANTHONY M (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Anabolism;Autophagocytosis;Biochemical;Biomass;Cell Physiology;Cells;Cellular Metabolic Process;Complex;Coupled;Disease;Disease Progression;DNA Repair;Ensure;Enzymes;Event;Fluorescence Microscopy;Glycolysis;Human;human disease;insight;Knowledge;malignant neurologic neoplasms;Mediating;Metabolic;Metabolic Pathway;Molecular;Molecular Biology;Molecular Chaperones;Multiprotein Complexes;Nervous System Disorder;novel therapeutic intervention;Nutrient availability;Parents;Phase;Predisposition;Proliferating;protein folding;Proteins;Proteome;Proteomics;proteostasis;Purines;recruit;Regulation;Signal Transduction;tool;ultra high resolution;Work

PROJECT_TITLE: Molecular Chaperone-mediated Regulation of Cell Metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Immunotherapy;Orphan Drug;Ovarian Cancer;Prevention;Rare Diseases;Vaccine Related;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PI_NAMEs: BLOCK, MATTHEW STEPHEN (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Adjuvant;Adjuvant Chemotherapy;analytical tool;Antibodies;antibody-dependent cell cytotoxicity;Antigens;cancer cell;cancer recurrence;chemotherapy;Clinic;Data;Dendritic Cell Vaccine;Diagnosis;Disease remission;Double-Blind Method;eosinophil;Future;Goals;Greater sac of peritoneum;Helper-Inducer T-Lymphocyte;high dimensionality;Immune;Immunization;improved;Interferon Type II;Macrophage;Maintenance;Malignant neoplasm of ovary;Mediating;mouse model;Neoadjuvant Therapy;novel;Operative Surgical Procedures;Outcome Measure;ovarian cancer prevention;Patients;Phagocytes;Phagocytosis;Phase;Phase II Clinical Trials;Physiologic pulse;Placebo Control;Platinum;pre-clinical;prevent;Production;programs;Randomized;recruit;relapse prevention;research clinical testing;resistance mechanism;response;T cell differentiation;T cell response;T-Lymphocyte;Testing;Therapeutic;tumor;Tumor Debulking;Vaccination;vaccine efficacy;Vaccines

PROJECT_TITLE: Th17 T cell-inducing vaccines for the prevention of ovarian cancer recurrence


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Genetics;Neurosciences;Pain Research;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Common chronic overlapping pain syndromes (COPCs), such as fibromyalgia and temporomandibular disorder, constitute one of our nation’s most significant healthcare problems, affecting nearly one in every three Americans. Despite their high prevalence, COPCs remain ineffectively treated, in large part, due to lack of valid animal models with translational relevance for discovery of safe effective therapies. Thus, the objective of this proposal is to develop and validate a novel mouse model of COPCs in which genetically predisposed mice undergo stressful and injurious events resulting in clinically-relevant behavioral and molecular phenotypes for in vivo screening of analgesic therapeutics.

PI_NAMEs: NACKLEY, ANDREA G (contact)

PROGRAM_OFFICER_NAME: ROOF, REBECCA

PROJECT_TERMS: Abdomen;Affect;American;Analgesics;Animal Model;Antiinflammatory Effect;anxiety-like behavior;Automobile Driving;Back;Behavior;behavioral phenotyping;Bilateral;Biological Markers;calcium indicator;Catechol O-Methyltransferase;Catecholamines;celecoxib;Chronic;chronic pain;Clinical;clinical effect;clinically relevant;Complex;cytokine;Data;depressive symptoms;duloxetine;effective therapy;Environmental Risk Factor;Enzymes;Etiology;Event;Exhibits;FDA approved;Female;Fibromyalgia;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;Genotype;Healthcare;High Prevalence;Hyperalgesia;improved;in vivo;in vivo calcium imaging;Individual;Inflammation;Inflammatory;Injury;Lead;male;Mastectomy;Measures;mechanical allodynia;Mechanics;meetings;Modeling;molecular phenotype;mouse model;multiplex assay;Mus;Nerve;Nociceptors;novel;Operative Surgical Procedures;Pain;pain behavior;pain model;pain reduction;Parents;Patients;Peripheral;Peripheral Nerves;Persistent pain;Persons;pharmacologic;Phase;Plasma;pregabalin;Production;psychologic;Reporting;response;Rodent;Rodent Model;Sampling;screening;Site;Stimulus;Stress;Stressful Event;Swimming;Syndrome;Temporomandibular Joint Disorders;Testing;Therapeutic;Time;Variant;Vehicle crash;Vulva;Wild Type Mouse;Woman;Work

PROJECT_TITLE: A novel clinically- relevant mouse model of chronic overlapping pain conditions for screening analgesics


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Our objective is to develop general principles for engineering proteases that can control signaling in cells. In accomplishing this objective we will develop tools for controlling signaling in a cell, and ultimately create avenues to advanced therapeutics.

PI_NAMEs: BRYAN, PHILIP N;ORBAN, JOHN  (contact);TOTH, ERIC A

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Active Sites;Adopted;Allosteric Site;Biochemical;Biological Models;Biophysics;Cancer cell line;Cancer Model;Catalysis;Cell Culture Techniques;Cell Line;Cell model;Cells;Cellular biology;Chemicals;cofactor;Complex;controlled release;design;Distal;Engineering;Enzymatic Biochemistry;Enzyme Precursors;experimental study;Generations;Goals;Homologous Gene;Human;Imidazole;improved;insight;interdisciplinary approach;Kinetics;Knowledge;KRAS2 gene;Libraries;Malignant neoplasm of urinary bladder;Methods;Modeling;Molecular;Molecular Conformation;Multidimensional NMR Techniques;mutant;Mutation;Nitrites;Oncogenic;pancreatic cancer cells;Peptide Hydrolases;Peptides;Phage Display;Protein Engineering;Protein Isoforms;Proteins;RAS genes;Reaction;Recommendation;Rhabdomyosarcoma;Roentgen Rays;Signal Transduction;Signaling Protein;Site;Specificity;Structure;System;Testing;Text;Therapeutic;tool;Variant;X-Ray Crystallography

PROJECT_TITLE: Engineering protein-specific proteases: targeting signaling proteins

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: ACCESS TO ADVANCED HEALTH INSTITUTE

ORG_STATE: WA

PHR: blah

PI_NAMEs: CASPER, COREY  (contact)

PROJECT_TERMS: Advanced Development;Animal Model;biodefense;Clinical;Communicable Diseases;Contracts;Disease Outbreaks;efficacy evaluation;efficacy testing;Emerging Communicable Diseases;Formulation;immunogenicity;Individual;manufacture;response;Safety;stability testing;Toxicology;vaccine candidate;vaccine development;Vaccines

PROJECT_TITLE: Advanced Development of Vaccine Candidates for Biodefense and Emerging Infectious Diseases


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

PI_NAMEs: WALTER, CHIP  (contact)

PROJECT_TERMS: Clinical;Clinical Trials;design;Development;Ethics;Evaluation;Human;Influenza A virus;influenza virus vaccine;innovation;National Institute of Allergy and Infectious Disease;Phase I Clinical Trials;sound;System;universal influenza vaccine;vaccine candidate;Vaccines

PROJECT_TITLE: Collaborative Influenza Vaccine Innovation Centers (CIVICs): Component C: Clinical Core


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Genetics

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative RNA molecules regulate gene expression post-transcriptionally through sequence elements that regulate translation, RNA stability, localization, and more. We define the mechanisms of RNA regulation and advance new approaches to reveal new modes of regulation, with relevance to basic biology and human disease.

PI_NAMEs: FLOOR, STEPHEN NICHOLAS (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;Area;Binding;Biological Assay;Biology;Cells;Cellular biology;Couples;Deaminase;Deamination;Development;Elements;Gene Expression;Genetic;Goals;Heterogeneity;Human;human disease;Individual;Measurement;Measures;Mediating;Messenger RNA;method development;Molecular;Molecular Biology;novel strategies;posttranscriptional;Proteins;Regulation;Research;Ribonucleoproteins;Ribosomes;RNA;RNA Sequences;RNA Stability;RNA-Binding Proteins;RNA-Protein Interaction;single molecule;Site;Systems Biology;Therapeutic;Training;Translations;Variant;Work

PROJECT_TITLE: The molecular grammar of human RNA biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: No Text

PI_NAMEs: HOLMES, KRISTI  (contact)

PROJECT_TERMS: Ecosystem;generalist repository;Text

PROJECT_TITLE: Zenodo and the Generalist Repository Ecosystem Initiative (GREI)


NIH_SPENDING_CATS: Data Science

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: CENTER FOR OPEN SCIENCE

ORG_STATE: VA

PI_NAMEs: PFEIFFER, NICI  (contact)

PROJECT_TERMS: Adopted;Architecture;Awareness;collaborative approach;Data;data ecosystem;data management;data resource;data reuse;Data Science;data sharing;data submission;Ecosystem;FAIR principles;Funding;generalist repository;Infrastructure;Mission;Modernization;open data;Reporting;Research Personnel;Services;social;Strategic Planning;Training;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: Center for Open Science (COS) Proposal for the NIH Generalist Repository Ecosystem Initiative (GREI)


ORG_CITY: NEW YORK

ORG_NAME: ELSEVIER, INC.

PI_NAMEs: SNOWDEN, TRACI  (contact)

PROJECT_TERMS: Adopted;Architecture;Awareness;collaborative approach;Data;data ecosystem;data management;data resource;data reuse;Data Science;data sharing;data submission;Ecosystem;FAIR principles;Funding;generalist repository;Infrastructure;Mission;Modernization;Reporting;Research Personnel;Services;social;Strategic Planning;Training;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: THE GENERALIST REPOSITORY ECOSYSTEM INITIATIVE (GREI)


ORG_CITY: CAMBRIDGE

ORG_NAME: VIVLI, INC.

ORG_STATE: MA

PI_NAMEs: LI, REBECCA H (contact)

PROJECT_TERMS: Adopted;Architecture;Awareness;Clinical Trials;collaborative approach;Data;data ecosystem;data management;data resource;data reuse;Data Science;data sharing;data submission;Ecosystem;FAIR principles;Funding;generalist repository;Infrastructure;Mission;Modernization;Reporting;Research Personnel;Services;social;Strategic Planning;Training;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: Vivli: A Generalist Repository For Clinical Trials Data


ORG_CITY: DAVIS

ORG_NAME: DRYAD

PI_NAMEs: GIBSON, JENNIFER  (contact)

PROJECT_TITLE: Dryad and the Generalist Repository Ecosystem Initiative (GREI)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Psychosis

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE: Psychotic symptoms (delusions and hallucinations) during Alzheimer disease cause substantial added burden for patients and families. Current medication treatments for psychosis in Alzheimer disease have limited benefits and cause substantial side effects. This project looks to accelerate the development of more effective medication treatments by generating detailed characterizations of altered protein levels in cortical synapses of individuals who experience psychosis during Alzheimer disease and using these characterizations to identify and test available medications for their ability to reverse the protein changes in mouse models of Alzheimer disease.

PI_NAMEs: KOFLER, JULIA K;SWEET, ROBERT A (contact);WANG, LIRONG

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: abeta accumulation;Acceleration;Actins;Administrative Supplement;Adult;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid beta-Protein;Animals;Antipsychotic Agents;Behavior;behavior test;Biology;Brain region;Caregiver Burden;CCR5 gene;Communities;conditioned fear;Cytoskeleton;Data;data sharing;Delusions;Dendritic Spines;density;design;Development;disability;Disease Progression;Dose;drug candidate;Drug Targeting;drug testing;effective therapy;Excess Mortality;excitatory neuron;experience;experimental study;Family;Funding;Goals;Hallucinations;Heritability;hTau Mice;Image;Impaired cognition;In Vitro;in vivo;Individual;inhibitor;Investigation;Investigational Therapies;Knowledge;Learning;Link;Measures;Memory;Methods;Modeling;Morbidity - disease rate;mortality;mouse model;multi-photon;Mus;Neurobiology;novel therapeutics;Outcome;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenotype;Phosphoproteins;phosphoproteomics;Positioning Attribute;postsynaptic;postsynaptic density protein;Protein Kinase;Proteins;Proteome;Proteomics;Psychoses;psychotic symptoms;Research;Resource Sharing;Resources;side effect;Signal Pathway;Signal Transduction;Structure;Synapses;Testing;therapeutic evaluation;therapy development;Toxic effect;Vertebral column

PROJECT_TITLE: Accelerating Treatment Development for Psychosis in AD: MODEL-AD+P - Supplement

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ORG_NAME: DIGITAL SCIENCE AND RESEARCH SOLUTIONS, INC.

PI_NAMEs: HAHNEL, MARK  (contact);VAN GULICK, ANA ELIZABETH

PROJECT_TERMS: Adopted;Architecture;Awareness;collaborative approach;Communities;Data;data ecosystem;data management;data resource;data reuse;Data Science;data sharing;data submission;Ecosystem;FAIR principles;Funding;generalist repository;Infrastructure;Mission;Modernization;Reporting;Research;Research Personnel;Services;social;Strategic Planning;Training;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: Advancing Figshare and the generalist repository landscape to meet research community needs


NIH_SPENDING_CATS: Natural Products

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Relevance to Public Health:  At the core of chemistry lies the power to manipulate the elements for the preparation of specific arrays of atoms in a predictable and reliable fashion. As synthetic chemists, our ability to construct molecules with exquisite precision is unique within the sciences. In this proposal, we outline broad approaches toward the construction of important linkages and describe the implemention of these methods in highly complex situations relevant to human medicine.

PI_NAMEs: STOLTZ, BRIAN M (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: The Synthesis of Bioactive Natural Products as a Driving Force for Discovery in Organic Chemistry


NIH_SPENDING_CATS: Microbiome

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative The goal of this supplement is to advance diversity in health-related research through the training and mentorship of Jasmine Walsh, a Black graduate student in the Chemical Biology PhD program at Harvard who is performing graduate research in the PI’s laboratory. The proposed research will substantially enhance one of the main projects on the R35 (GM128618), the investigation of how gut bacteria metabolize endogenous steroid hormones and how these steroid metabolites affect host function. This supplement will provide Jasmine with important research experience, mentorship, and career development opportunities while also advancing our understanding of how human gut bacteria affect host health and disease.

PI_NAMEs: DEVLIN, ABIGAIL SLOAN (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Affect;Analytical Chemistry;bacterial metabolism;Biochemistry;Biology;Black race;career;career development;Cell Culture Techniques;Chemicals;Development Plans;Disease;Doctor of Philosophy;Enzymes;experience;Female;germ free condition;Glucocorticoids;Gnotobiotic;Goals;Gonadal Steroid Hormones;graduate student;gut bacteria;Health;Human;Human Microbiome;immune function;In Vitro;in vivo;Investigation;Jasminum;Laboratories;Mentorship;Metabolism;Microbiology;microbiome;Mission;Mus;neurosteroids;Parents;pregnant;Progesterone;Progesterone Receptors;Progestins;programs;Receptor Signaling;Research;Research Training;Running;steroid hormone;Steroids;Training;Underrepresented Populations;United States National Institutes of Health

PROJECT_TITLE: Human microbiome metabolites in health and disease

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Cannabinoid Research;Endocannabinoid System Research;Nutrition;Obesity

ORG_NAME: CITY COLLEGE OF NEW YORK

PHR: Animal studies have demonstrated that the regulation of food intake requires articulation among endogenous cannabinoids (ECs), fatty acid-binding proteins (FABPs), and a peroxisome proliferator- activated nuclear receptor (PPARa), but the macromolecular basis for appetite, satiety, and obesity is poorly understood. This project will probe the solution-state macromolecular structure and function of EC- FABP, EC-PPAR, and FABP-EC-PPAR complexes in vitro at near-physiological concentrations, determining affinities, metabolic fates, molecular binding interfaces, and conformational changes to test proposed mechanisms of EC metabolic signaling. Working as a team with research trainees, our work will help to understand health risks and design future therapies for heart disease, autoimmune disorders, and type-2 diabetes.

PI_NAMEs: STARK, RUTH E. (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Abbreviations;Address;Administrative Supplement;Affinity;Amides;Animal Model;Animals;Appetite Regulation;Applications Grants;Articulation;Autoimmune Diseases;Binding;Binding Proteins;Binding Sites;Biological Assay;Biophysics;career;Cell Nucleus;Chemicals;Chimera organism;Complex;design;Desire for food;Diffusion;Dissociation;Drug Design;Drug Modulation;endocannabinoid signaling;Endocannabinoids;Enterocytes;Enzymes;Esters;Exhibits;experimental study;fatty acid amide hydrolase;fatty acid-binding proteins;Fatty Acids;Fluorescence;Food Intake Regulation;Future;Genetic Transcription;Glycerol;Health;heart disease risk;Heart Diseases;Human;Hydrophobicity;In Vitro;in vitro testing;Inflammation;Intestines;Knock-out;Knockout Mice;Ligand Binding;Ligand Binding Domain;Ligands;Lipase;Liver;Measures;Mediating;member;Metabolic;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;Molecular Structure;Monitor;Mus;neuroprotection;NMR Spectroscopy;Non-Insulin-Dependent Diabetes Mellitus;Nuclear Receptors;Obesity;Outcome;Pain;Pattern;Peroxisome Proliferator-Activated Receptors;Peroxisome Proliferators;Phenotype;Physiological;preference;pressure;programs;Protein Binding Domain;protein complex;protein protein interaction;Proteins;receptor binding;recruit;Regulation;Relaxation;Research;Risk;Role;Satiation;Signal Transduction;Signaling Molecule;Site;Surface Plasmon Resonance;Testing;Thermodynamics;Thinness;thyroid hormone receptor associated protein 220;Titrations;Underrepresented Populations;United States National Institutes of Health;Vertebral column;Work

PROJECT_TITLE: Administrative Supplement for Diversity


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: DAVIDSON

ORG_DEPT: BIOLOGY

ORG_NAME: DAVIDSON COLLEGE

PHR: Project Narrative Bacteria are engaged in an eternal struggle against viruses that infect them named phages. Some bacterial anti-phage defense systems involve proteins called OLD proteins, and here we propose basic biology experiments to investigate OLD proteins so that we might shed light on the molecular basis by which they engage with DNA and contribute to anti-phage defense. Studying the mechanisms by which bacteria defend themselves can lead to biotechnological advances like the CRISPR system, as well as contribute to the development of phage therapy to overcome antibiotic-resistant bacteria.

PI_NAMEs: THURTLE-SCHMIDT, BRYAN H (contact)

PROJECT_TERMS: Amino Acids;ATP Hydrolysis;ATP phosphohydrolase;ATPase Domain;Bacteria;Bacterial Antibiotic Resistance;Bacteriophage lambda;Bacteriophages;Basic Science;Binding;Biochemical;Biological;Biological Assay;Biology;Biomedical Research;Biotechnology;Burkholderia pseudomallei;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Combating Antibiotic Resistant Bacteria;CRISPR/Cas technology;Defect;design;Development;DNA;DNA Restriction Enzymes;DNA Restriction-Modification Enzymes;experience;experimental study;Family;Gel;Genes;Genetic;Genome;Goals;helicase;Helicase Gene;Hydrolysis;insight;Kinetics;Mediating;Molecular;Mutation Analysis;Names;nuclease;Nucleic Acid Biochemistry;Nucleotides;Orthologous Gene;Plaque Assay;Play;Prophages;protein function;Proteins;Research;Role;Sepharose;structural biology;System;Testing;Therapeutic;Therapeutic Intervention;Training;undergraduate student;Virus

PROJECT_TITLE: OLD family nuclease function across diverse anti-phage defense systems

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (81)]


NIH_SPENDING_CATS: Biotechnology;Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Nutrition;Obesity;Pediatric;Prevention;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Gestational and early childhood exposures, including maternal metabolic status and breastfeeding, are increasingly recognized as critical in the development of childhood and life-long obesity. The proposed research seeks to comprehensively assess the impact of maternal metabolic status on early childhood growth and metabolism, through the gene regulatory dynamics of placental and breastmilk microRNAs. This research has the potential to advance our understanding of the contribution of microRNAs and early-life exposures on growth and metabolism, and to more broadly contribute the Developmental Origins of Health and Disease.

PI_NAMEs: GOEHRING, ELIZABETH MARIE KENNEDY (contact)

PROGRAM_OFFICER_NAME: BROCKWAY, HEATHER MARIE

PROJECT_TERMS: 3' Untranslated Regions;absorption;Adult;Advisory Committees;Affect;Automobile Driving;Base Pairing;Bioinformatics;Biological Markers;Biology;Birth;Birth Weight;Body mass index;Breast Feeding;Breastfed infant;Cardiovascular Diseases;career;Child;Child Health;Childhood;circulating microRNA;Code;cohort;Cohort Studies;Data;Development;Disease;disorder prevention;DNA Methylation;early childhood;early life exposure;Educational Status;empowerment;Epidemiologic Methods;Epidemiologist;Epidemiology;epidemiology study;Epigenetic Process;epigenetic regulation;experience;extracellular;Faculty;Fetal Growth;follow-up;Future;Gene Expression;Genes;Genetic;Genetic Research;Genetic Transcription;genetic variant;genome-wide;Genomics;Genotype;gestational weight gain;Goals;Growth;Health;high risk;Home;Human Genetics;Human Milk;improved;Infant;insight;interest;Intestines;Knowledge;Life;Measures;Mediating;Mediator;Mentors;Mentorship;Messenger RNA;Metabolic;Metabolic Diseases;Metabolism;Methods;MicroRNAs;Molecular;Molecular Epidemiology;multiple omics;National Institute of Child Health and Human Development;New Hampshire;next generation;nutrition;obese mothers;Obesity;obesity in children;obesity risk;offspring;Outcome;Pattern;Phase;Placenta;Placental Biology;Population;population based;Population Study;Positioning Attribute;posttranscriptional;Pregnancy;prepregnancy;Proteins;Public Health Schools;Quantitative Trait Loci;Recommendation;Research;Research Design;Research Personnel;Research Project Grants;research study;Research Support;Resources;response;Rhode Island;Role;Secure;skills;Stimulus;tenure track;Testing;Tissues;Training;Transcript;transcriptome;transcriptomics;transgene expression;Universities;Untranslated RNA;Variant;Weight;Work

PROJECT_TITLE: Placental and breastmilk microRNAs in relation to early-life growth and metabolism


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: DALLAS

ORG_NAME: VA NORTH TEXAS HEALTH CARE SYSTEM

PHR: Contrast-associated acute kidney injury occurs frequently after coronary angiography and percutaneous coronary intervention in patients with heart failure with reduced left ventricular ejection fraction. Although, periprocedural administration of intravenous fluid, has been the standard intervention to prevent contrast- associated acute kidney injury, patients with congestive heart failure may not tolerate intravenous fluid. Unfortunately, there is no alternative therapy to prevent contrast-associated acute kidney injury in patients with congestive heart failure. This project will determine the effect of remote ischemic preconditioning on contrast-associated acute kidney injury in Veterans with congestive heart failure with reduced left ventricular ejection fraction who cannot tolerate intravenous fluid. It will characterize the effect of remote ischemic preconditioning on functional capacity and major adverse kidney events in Veterans with congestive heart failure with reduced left ventricular ejection fraction undergoing coronary angiography.

PI_NAMEs: OLAFIRANYE, OLADIPUPO  (contact)

PROJECT_TERMS: Activities of Daily Living;Acute Renal Failure with Renal Papillary Necrosis;Adult;Alternative Therapies;Angiography;Blood flow;Blood Pressure;Blood Vessels;Brain natriuretic peptide;Cardiac;Cell Cycle Arrest;Cessation of life;clinical practice;Clinical Trials;Complication;Congestive Heart Failure;contrast enhanced;Contrast Media;cooperative study;Coronary;Coronary Angiography;Coronary Arteriosclerosis;cost;Cytoprotection;Data;Data Analyses;design;Diagnosis;Diagnostic Imaging;Double-Blind Method;Elderly;Epithelial Cells;Event;Exclusion;Exposure to;Free Radicals;Generations;Growth;Heart;Heart failure;Heart Rate;Helicopter;hemodynamics;high risk;Hospital Mortality;Hospitalization;imaging study;improved;Incidence;Intervention;Intravenous;intravenous administration;Ischemia;ischemic injury;Ischemic Preconditioning;Isotonic Exercise;IV Fluid;Kidney;kidney cell;kidney dysfunction;Left Ventricular Ejection Fraction;Length of Stay;Life;Limb structure;Long-Term Effects;media use;Mediating;military veteran;Molecular;Monitor;Morbidity - disease rate;mortality;Multicenter Trials;Myocardial;Myocardial Infarction;Nature;Nitrites;novel therapeutics;Organ;Outcome;Participant;patient population;Patients;percutaneous coronary intervention;Persons;Plasma;Population;pressure;Prevalence;prevent;Prevention;Preventive therapy;primary outcome;Procedures;Process;programs;prophylactic;Proteins;Randomized Controlled Clinical Trials;randomized, clinical trials;renal ischemia;Renal Replacement Therapy;Reperfusion Therapy;Research Project Grants;Risk;Role;Safety;Saline;secondary outcome;Serum;Subgroup;Symptoms;Testing;Time;Toxic effect;Translations;Tubular formation;United States Department of Veterans Affairs;vasoconstriction;Vasodilation;Veterans;Walking

PROJECT_TITLE: Remote ischemic preconditioning for renal and cardiac protection in congestive heart failure (RICH) trial


ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Insulin-producing beta cells can be destroyed by CD8 T cells that recognize self-antigens. We have shown that these cells can be found in high numbers in the pancreatic islets of human donors with diabetes, and we have systematically analyzed antigen-specific CD8 T cells in the endocrine and exocrine pancreas. In the present proposal we will precisely delineate the phenotype, function, and location of antigen specific CD8 T cells and use the state-of-the-art multiplexing tool (Orion) and state-of-the-art machine learning analysis to deter- mine their precise spatial distribution within the whole pancreatic section, and to uncover complex cellular interactions and mechanisms. We will corroborate these findings in highly innovative dynamic in vitro mod- els using human islet microtissues and living donor tissue slices, and finally we will investigate the mech- anisms by which some aspects of the islet immune interface can be restored by the action of GLP1 ago- nists.

PI_NAMEs: QUESADA MASACHS, ESTEFANIA  (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Agonist;Antigen-Presenting Cells;Antigens;Autoantigens;Autoimmune Diseases;autoimmune pathogenesis;Automobile Driving;autoreactive T cell;autoreactivity;Beta Cell;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;cell injury;Cell Physiology;cell type;Cells;Characteristics;chronic autoimmune disease;Communication;Complex;Computer software;Coupling;cytokine;Cytotoxic T-Lymphocytes;Data;design;Development;Diabetes Mellitus;diabetes pathogenesis;Diagnosis;Disease;Endocrine;Environment;Event;Evolution;Exocrine pancreas;Exposure to;Frequencies;Funding;GCG gene;GLP-I receptor;Glucose;Goals;Grant;Heterogeneity;Human;human tissue;Image Analysis;Immune;Immune mediated destruction;Immune system;Immunomodulators;improved;In Situ;In Vitro;in vitro Model;in vivo;Infiltration;Inflammatory;innovation;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;insulitis;intercellular communication;Invaded;Investigation;islet;Islet Cell;Islets of Langerhans;Lesion;Living Donors;Location;Machine Learning;Macrophage;Maintenance;Metabolic;Methods;Modeling;Mus;Neighborhoods;non-diabetic;novel;novel strategies;novel therapeutics;Organ Donor;Organoids;Pancreas;Pathogenesis;Patients;Peptides;Pharmaceutical Preparations;Phenotype;Prediabetes syndrome;preproinsulin;preservation;Probability;Production;Property;Residual state;response;restraint;Role;Sampling;Seminal;Slice;Spatial Distribution;spatiotemporal;Specificity;Specimen;spheroids;Stains;Stress;Structure of beta Cell of islet;System;T-Lymphocyte;Techniques;Technology;timeline;Tissue Donors;Tissues;tool;Up-Regulation;Work

PROJECT_TITLE: Specificity, Phenotype and Function of Pancreatic CD8 T Cells in Human Type 1 Diabetes


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Administrative Supplement to Purchase Infrared Imager Narrative We are requesting funds to purchase a Near Infrared Imager to be used by the Laederach research laboratory, which is currently supported by NIGMS (R35GM140844; Donna Krasnewich PO). The cost of the LiCor DLx infrared imager is $66,600 and is therefore above the range of equipment that can be purchased using current grant funds. The imager will be installed in the Genome Sciences Building blue pod and it will be shared with UNC researchers with broad biomedical interests, many funded by NIH and NIGMS.

PI_NAMEs: LAEDERACH, ALAIN T (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Acceleration;Administrative Supplement;Biological;Cell Nucleus;cost;Cytoplasm;Data;digital imaging;Ensure;Equipment;experimental study;Fluorescence;Funding;Gene Expression;genome sciences;Grant;Home;Image Analysis;imager;instrument;interest;Laboratory Research;Measures;National Institute of General Medical Sciences;Post-Transcriptional Regulation;programs;protein expression;Proteins;Reproducibility;Research;Research Personnel;Resources;RNA;RNA Splicing;Role;Sampling;Scanning;Signal Transduction;Structure;Syncope;Translating;United States National Institutes of Health;Visualization;Western Blotting;Work

PROJECT_TITLE: Equipment Supplement to Purchase Infrared Imager