NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Health Services;Infectious Diseases;Lung

ORG_CITY: PHILADELPHIA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative  Viral respiratory tract infections such as influenza and COVID-19 cause substantial suffering worldwide. Though screening diagnostics, which identify infected individuals quickly before they spread disease widely, are an effective containment strategy during outbreaks, no testing platform exists today that has the capacity to check hundreds of millions of people daily. This study aims to develop a novel screening diagnostic based on mass-manufacturable microscopic circuits that detect viruses, which will enable nimble widespread testing during future pandemics.

PI_NAMEs: CAMPBELL, MATTHEW FREDERICK (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Acceleration;Affect;Algorithms;Antibodies;antigen binding;Antigens;Applied Research;aptamer;Area;Award;Biological;Biological Assay;Biology;Biomedical Engineering;Biomedical Research;Biosensor;career;career development;Cations;Cellular Phone;Chemicals;Clinical;clinically relevant;combat;contagion;Containment;COVID-19;COVID-19 detection;COVID-19 pandemic;data exchange;Databases;design;detector;Development;Development Plans;Diagnostic;diagnostic platform;diagnostic screening;Disease;Disease Outbreaks;Doctor of Medicine;Economic Burden;Electric Conductivity;emerging virus;Engineering;Environment;Epidemic;experience;Eye;fabrication;feasibility testing;flexibility;Funding;Future;future pandemic;Goals;handheld equipment;Human;human disease;Immobilization;Immunoassay;Individual;Influenza;instrument;integrated circuit;Investigation;K-Series Research Career Programs;Label;Light;light emission;manufacture;Measurement;Medical;Mentors;Mentorship;Methods;Microscopic;Middle East Respiratory Syndrome Coronavirus;Mucous body substance;multiplex detection;nanofabrication;nanowire;novel;novel coronavirus;Nucleic Acids;Optics;pandemic disease;Patients;Pennsylvania;Persons;Plants;Play;point of care;Population;portability;Positioning Attribute;Postdoctoral Fellow;Procedures;Production;professor;Property;Reader;receptor;Research;Research Personnel;Resources;respiratory;Respiratory Tract Infections;response;saliva sample;Sampling;SARS coronavirus;Scheme;Schools;screening;seasonal influenza;Secure;Semiconductors;sensor;signal processing;Silicon;skills;Solvents;Source;Specificity;Specimen;Surface;Swab;System;tenure track;Test Result;Testing;Thinness;tool;Training;Transistors;two-dimensional;United States;United States National Institutes of Health;Universities;Viral;viral detection;Viral Respiratory Tract Infection;Virus;wireless;Work

PROJECT_TITLE: Rapidly Adaptable and Mass-Producible Microscopic Chiplets for Minimally-Instrumented Respiratory Viral Screening

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE: Aging is the biggest risk factor for multiple inflammation dependent chronic diseases. FGF21 is a hormone, that can lower inflammation and extend healthy lifespan. The proposed studies in this program project will study the mechanism of action of FGF21 that promotes health and test the prediction that increasing FGF21 levels in in mice will reduce age-related disease burden.

PI_NAMEs: DIXIT, VISHWA DEEP (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Adipocytes;adiponectin;Adipose tissue;Adult;Affect;Affinity;age related;age related chronic disease;age-related disease;Aging;aging process;Agonist;anti aging drug;Behavior;Behavioral;Binding;Biological;Body System;burden of illness;Caloric Restriction;Chronic Disease;Complex;Consumption;Data;Development;Elderly;Endocrine;energy balance;Energy Metabolism;Epithelium;Evaluation;Fasting;fatty acid oxidation;Fibroblast Growth Factor;fibroblast growth factor 21;Fibroblast Growth Factor Receptors;Generations;Gerontology;geroprotector;glucose metabolism;Goals;Growth;hallmarks of aging;Health;Health Promotion;healthspan;Homeostasis;Hormones;Human;Hypothalamic structure;Immune;Immunologics;immunosenescence;Impairment;improved;Inflammaging;Inflammation;insulin sensitivity;ketogenesis;Knockout Mice;Knowledge;Leptin;life span;Ligands;Ligation;lipid metabolism;Lipids;Liver;Longevity;Lymphopoiesis;Mediating;Medical center;member;Membrane;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Modality;Modeling;Molecular;mouse model;Mus;Nature;neural;Neurons;novel;novel strategies;old mice;Organ;overexpression;Pathway interactions;pharmacologic;Physiological;pre-clinical;Program Research Project Grants;programs;Protein Tyrosine Kinase;Proteins;receptor;recruit;Regulation;Research;Research Personnel;response;Risk Factors;Role;senescence;Signal Transduction;skills;Structure;Sympathetic Nervous System;Testing;Texas;Thymus Gland;Tissues;Translations;Universities;Variant

PROJECT_TITLE: Competing Renewal P01


NIH_SPENDING_CATS: Aging

PROJECT_TERMS: Advisory Committees;Award;Collaborations;Communication;Communities;Consultations;Data;Data Analyses;Data Storage and Retrieval;Development Plans;Education;Ensure;experience;Funding;Future;Goals;Human;Immune;immunosenescence;Inflammaging;Intramural Research Program;Medical center;meetings;member;Metabolic;mouse model;Mouse Strains;Occupational activity of managing finances;Participant;Personnel Management;Process;programs;Progress Reports;Reagent;Recommendation;Reporting;Research Personnel;Research Training;Resource Sharing;Role;Scientific Advances and Accomplishments;Services;statistics;Suggestion;Transgenic Mice;United States National Institutes of Health

PROJECT_TITLE: Admin-Core


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: RIVERSIDE

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

ORG_STATE: CA

PHR: NARRATIVE The research proposed has significant relevance to public health because there are not many study systems to investigate the mechanisms underlying evolutionary genetic and phenotypic changes in host-parasite interactions. Parasitism by helminths (worms) is hypothesized to have driven population genetic changes in human, animal, and plant hosts, contributing to auto-immune pathologies and placing burdens on growth and development, but data obtained using a combination of evolutionary, genome-wide, and functional genetic approaches from genetically tractable host-parasite study systems is necessary to address this question. Thus, the research proposed pertains to NIGMS's research mission of understanding the principles, mechanisms, and processes that underlie living organisms, and NIH’s mission area of developing fundamental knowledge that will help to (1) sustainably reduce the burdens of parasitism and autoimmune pathologies and (2) advance our understanding of how selection shapes genetic and phenotypic variation in hosts and parasites over time.

PI_NAMEs: GROEN, SIMON CORNELIS (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Animals;Area;Autoimmune;Biological Models;Comprehension;Data;Ecology;Evolution;Experimental Genetics;fitness;Genes;Genetic;genetic approach;genetic architecture;genetic variant;Genetic Variation;genome-wide;genome-wide analysis;Genomics;geographic difference;Geography;Goals;Growth and Development function;Helminths;Host resistance;Human;Immune system;Infection;infection rate;innovation;Intervention;Knowledge;Laboratories;Link;Mission;Molecular Genetics;Mutation;National Institute of General Medical Sciences;Natural Selections;Nematoda;Organism;Outcome;Parasites;parasitism;Pathology;Phenotype;Plants;Population;Population Genetics;pressure;Process;programs;Public Health;Research;Research Personnel;Resistance;Shapes;System;Systems Biology;Temperature;Testing;Time;trait;United States National Institutes of Health;Variant

PROJECT_TITLE: Evolutionary Systems Biology of Host-Parasite Interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


PHR: Core B: Project Narrative: The analysis of lifespan and healthspan in mice require specialized and centralized facility to conduct metabolic testing, behavior tests like age-related changes in memory and cognition. The mice where local FGF21 levels are elevated are predicted to live long. This Core will conduct detailed analyses of disease burden and pathology to determine the cause of lifespan extension and to understand the aging process.

PROJECT_TERMS: Adipose tissue;age related;age related changes;Aging;aging process;Animal Experimentation;animal resource;Animals;behavior test;Biological Assay;Biology of Aging;Body System;bone;Breeding;burden of illness;Cause of Death;Cells;Chronic Disease;Cognition;Control Groups;Core Facility;Development;Diet;drinking water;Environment;Euthanasia;Evaluation;experience;Experimental Designs;extend lifespan;Female;FGF21 gene;Fibroblast Growth Factor;fibroblast growth factor 21;frailty;functional decline;Generations;Genotype;Goals;Growth;gut microbiota;Health Status;healthspan;Immune system;Immunologic Markers;immunosenescence;improved;Individual;Inflammaging;Inflammasome;Infrastructure;insight;Knock-out;life span;Link;Liver;Longevity;Lymphoid Tissue;male;Malignant Neoplasms;Measures;medical schools;Memory;Metabolic;metabolic phenotype;Metabolism;Microbial Biofilms;middle age;Modality;Modeling;Molecular;Monitor;mouse model;Mus;Neurons;novel;old mice;overexpression;Pathologic;Pathology;Pathway interactions;Performance;Phase;Physiology;primary endpoint;Procedures;programs;Protocols documentation;Receptor Protein-Tyrosine Kinases;Regulation;Research;Research Project Grants;Resources;Role;Signal Transduction;skills;Standardization;Sterility;System;Testing;Time;Tissues;Transgenic Mice;Translating;Tumor Burden;Variant;ventilation;Water;Work

PROJECT_TITLE: Healthspan Core


PHR: NARRATIVE STATEMENT Thymus produces immune cells called as T-lymphocytes that are critical for protection against infections and cancers. However, with age, thymus is replaced with fat cells and its ability to produce T-cells is diminished. This research project will understand the effect of pro-longevity hormone FGF21 on rejuvenation of immune system of aged mice and to determine its mechanism of action in reducing inflammation.

PROJECT_TERMS: Adipocytes;Adipose tissue;Advocate;Age;age related;aged;Aging;Agonist;Automobile Driving;beta-Hydroxybutyrate;Biological;Biological Availability;Biological Process;Bone Marrow;burden of illness;Caloric Restriction;Catecholamines;CD8-Positive T-Lymphocytes;cell growth;Cells;Chronic;Clinical;Clone Cells;Coenzyme A;cohort;Collaborations;Consumption;Coronavirus Infections;COVID-19;Data;Development;Dietary Intervention;Elderly;Emerging infection;Enzymes;extend lifespan;Failure;Family;fatty acid oxidation;FGF2 gene;FGF21 gene;Fibroblast Growth Factor;fibroblast growth factor 21;Fibroblasts;Funding;Gerontology;Goals;Growth;Growth Factor;healthspan;Hematopoietic Stem Cell Transplantation;Homeostasis;Hormones;Human;Immune;Immune system;Immune Targeting;Immunologic Surveillance;Immunologics;immunosenescence;improved;Infection;Inflammaging;Inflammasome;Inflammation;Inflammatory;influenza infection;Intervention;ketogenesis;ketogentic;Ketone Bodies;life span;Lipids;Lipoatrophy;Lipolysis;Liver;Longevity;Lyase;Lymphopoiesis;Macrophage;Malignant Neoplasms;Mediating;Metabolic;Metabolic hormone;Metabolism;Mitochondria;Modeling;Morbidity - disease rate;mouse model;Mus;nerve supply;neural;novel;old mice;Organ;overexpression;Patients;Peripheral;Phenotype;primary lymphoid organ;Production;Proliferating;Proteins;receptor;Rejuvenation;Research;Research Project Grants;Resistance;response;Risk;Severities;Sympathetic Nervous System;T cell reconstitution;T-Cell Immunologic Specificity;T-Lymphocyte;Testing;Thymic epithelial cell;Thymus Gland;Transgenic Mice;Tyrosine 3-Monooxygenase;Vaccination;Validation;vigilance

PROJECT_TITLE: Project 1 - Dixit


NIH_SPENDING_CATS: Aging;Nutrition;Obesity

PHR: Relevance Statement Adipose tissue physiology plays a central role in systemic energy homeostasis. We know that FGF21 expression in adipocytes exerts a profound positive effect on health- and lifespan. Here, we want to focus on FGF21-induced changes in adipose tissue that lead to systemic improvements in overall metabolic homeostasis. We will focus on immune-metabolic changes, how they translate into metabolomic and gene expression alterations, with a particular focus on the impact on leptin and adiponectin, and how these adipokines synergize and antagonize FGF21 action. Combined, this will delineate how a fat pad needs to be changed to exert o potently positive impact on health- and lifespan.

PI_NAMEs: SCHERER, PHILIPP E (contact)

PROJECT_TERMS: Adipocytes;adipokines;adiponectin;Adipose tissue;Adult;Affect;age related;aged;Aging;aging process;Anti-Inflammatory Agents;Antiatherogenic;Area;Attention;autocrine;Beta Cell;Biological Assay;Body Weight;Body Weight decreased;Brain;Brown Fat;Cell Survival;cell type;Cells;Chronic;Circulation;Closure by clamp;Collaborations;comparison control;Data;Drops;Eating;Endocrine;Energy Metabolism;Exhibits;exosome;extend lifespan;Fatty acid glycerol esters;Fatty Liver;FGF21 gene;fibroblast growth factor 21;Fibrosis;Funding;Gene Expression Alteration;Glucose;Health;healthspan;High Fat Diet;Homeostasis;Hormones;Hour;Immune;improved;Inflammaging;Inflammation;Inflammatory;Insulin;insulin mediators;insulin sensitivity;Knock-out;Knockout Mice;Leptin;life span;Light;Lipids;Liver;Longevity;Mediating;Mediator;Metabolic;Metabolic Control;Metabolic Diseases;metabolic profile;Metabolism;metabolomics;mortality;mouse model;Mus;novel;Obesity;old mice;overexpression;pharmacologic;Phenotype;Physiological;Physiological Processes;Physiology;Plasma;Play;postmitotic;preservation;programs;Proteins;response;Role;senescence;Serum;Signal Transduction;single nucleus RNA-sequencing;Spleen;synergism;systemic inflammatory response;Transgenic Animals;Transgenic Mice;Translating;Visceral fat;Work

PROJECT_TITLE: Project2: Impact of adipose-tissue derived FGF21 on immunometabolic control of aging


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Data Science;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative The proposed expansion, improvement, and support of IPUMS are directly relevant to the central mission of the National Institutes of Health as the steward of medical and behavioral research for the nation. These data are advancing fundamental knowledge about human population dynamics, and they address key priorities of the Population Dynamics Branch of NICHD. This infrastructure will multiply the quality, quantity, accessibility, and interoperability of information about the human population, creating a resource of unprecedented power for understanding ongoing transformations of demographic behavior and population health.

PI_NAMEs: CLEVELAND, LARA L;RUGGLES, STEVE  (contact);SOBEK, MATTHEW

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Archives;Asia;Behavior;Behavioral Research;Censuses;Collaborations;Communities;computerized data processing;Country;Creativeness;Data;data access system;data acquisition;data cleaning;Data Discovery;data dissemination;data harmonization;data infrastructure;data ingestion;Databases;Development;Economics;Educational workshop;Elements;environmental change;Europe;Family Demographies;Fertility;Funding;global health;Growth;Health;Health behavior;Health Surveys;Household;Human;improved;Individual;Infrastructure;innovation;International;interoperability;Investments;Knowledge;Medical Research;Metadata;Mission;mortality;National Institute of Child Health and Human Development;Nuptiality;Online Systems;outreach;parity;Persons;Planets;Population;Population Dynamics;Population Growth;population health;population movement;preservation;Process;Publications;Publishing;Research;Research Personnel;Research Support;Resources;Risk;Running;Sampling;Secure;Shapes;social;Source;Surveys;System;Training;United States National Institutes of Health

PROJECT_TITLE: Integrated International Microdata for Population Dynamics and Health Research

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Narrative Several human illnesses such as chronic viral infection, cancer, autoimmunity, and neurodegenerative diseases are due to aberrant activation of innate immune responses and are associated with production of proinflammatory cytokines. We have identified a novel repressor complex composed of Capicua-Ataxin1 or 1L, which prevents aberrant expression of antiviral genes in the absence of virus infection; and, upon viral infection, this complex is rapidly degraded to turn on antiviral responses. Our proposed study will investigate the Capicua-Ataxin1 mediated regulation of innate immune responses in human cells and knock out mouse models.

PI_NAMEs: MANICASSAMY, BALAJI  (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: A549;airway epithelium;Anti-viral Response;ATAC-seq;ataxin-1;Autoimmune Diseases;Binding;Binding Sites;Biological Assay;Bone Marrow;Cancer Model;cancer type;cell type;Cells;ChIP-seq;Chromatin;chromatin immunoprecipitation;Chronic;comparison control;Complex;CRISPR screen;cytokine;Dendritic Cells;derepression;Diabetes Mellitus;Disease;Distal;DNA;DNA Binding;Drosophila genus;Elements;Embryo;Embryonic Development;Encephalomyocarditis virus;Enterobacteria phage P1 Cre recombinase;Epithelial Cells;Fibroblasts;Gene Expression;gene repression;Genes;genetic corepressor;Genetic Transcription;genome-wide;Goals;Homeostasis;Human;IFIH1;Immune;Immunity;in vivo;Infection;Inflammatory;Influenza A virus;influenza infection;Innate Immune Response;insight;Integration Host Factors;Interferon Type I;Interferon Type II;Interferon-beta;Interferons;IRF3 gene;ISG15 gene;Knock-out;Knockout Mice;loss of function mutation;Luciferases;Macrophage;Malignant Neoplasms;Mediating;microbial;Modeling;mouse model;multicatalytic endopeptidase complex;Mus;Mutate;Natural Immunity;Nerve Degeneration;Neurodegenerative Disorders;neuron development;novel;Nucleic Acids;Pathway interactions;Pattern recognition receptor;Post-Translational Protein Processing;prevent;Production;promoter;Promoter Regions;Receptor Activation;Receptor Protein-Tyrosine Kinases;Regulation;Reporter;Repression;Repressor Proteins;Respiratory System;RNA;RNA Viruses;Role;sensor;Spinocerebellar Ataxias;STAT1 gene;Stimulus;transcription factor;Transcription Repressor;Transcriptional Regulation;transcriptome sequencing;Up-Regulation;Validation;Vesicular stomatitis Indiana virus;Viral;Viral Genes;Virus;Virus Diseases;Virus Replication;Zika Virus

PROJECT_TITLE: Regulation of innate antiviral responses by the DNA-binding transcriptional repressor complex CIC-ATXN1/L


NIH_SPENDING_CATS: Aging;Neurosciences;Nutrition

PHR: Narrative Project 3: The role of AgRP/Augα-ALK pathway in FGF21’s brain action on aging This project tests the relevance for anew brain pathways in aging associate with FGF21.

PI_NAMEs: HORVATH, TAMAS L (contact)

PROJECT_TERMS: age related;Aging;aging related;ALK Pathway;Animals;Behavior;Behavioral;Blood - brain barrier anatomy;Brain;brain pathway;burden of illness;Caloric Restriction;Cells;Collaborations;Development;Energy Metabolism;Etiology;Event;FGF21 gene;Fiber;fibroblast growth factor 21;glucose metabolism;Hippocampus;Hypothalamic structure;Impairment;Incidence;knock-down;knockout animal;life span;Ligands;male;Malignant Neoplasms;Mediating;Metabolic;Modality;Mus;neoplastic;Neurons;new therapeutic target;novel;Outcome;paraventricular nucleus;Pathway interactions;Peripheral;Phenotype;Receptor Protein-Tyrosine Kinases;Regulation;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Structure of nucleus infundibularis hypothalami;Testing;Thinness;Tissues

PROJECT_TITLE: The role of AgRP/Auga-ALK pathway in FGF21's brain action on aging


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: NARRATIVE We will use state-of-the-art transcriptomic and epigenomic technologies to produce single cell resolution, multi- modal and multiscale spatial maps of cellular senescence in male and female mouse brain, liver, bone marrow, breast and colon. The planned research will improve our understanding of cellular senescence in these vital organs and provide key references for the functional characterization of senescent cells in healthy and disease states.

PI_NAMEs: ADAMS, PETER D. (contact);REN, BING

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Address;Age;age-related disease;Aging;aging related;animal old age;Atlases;biological age;Biological Assay;Bone Marrow;Brain;Breast;Cell Aging;Cells;Cellular Assay;Characteristics;Chromatin;Chronology;Clinic;Collaborations;Colon;Data;Data Analyses;data sharing;Development;Disease;DNA Methylation;Environment;Epigenetic age;Epigenetic Process;epigenome;epigenomics;Exhibits;experience;Female;Functional disorder;Future;Gene Expression;Genetic;genetic approach;Genetic Markers;Goals;hallmarks of aging;Health;Health Benefit;Heterogeneity;histone modification;Human;human old age (65+);human tissue;Immunology;improved;In Situ;In Vitro;in vivo;Individual;Inflammatory;innovation;Knowledge;life span;Link;Liver;male;Maps;Measurement;Modeling;Molecular;mouse model;Mouse Strains;multimodality;multiple omics;Mus;Neighborhoods;old mice;Organ;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Population;Proliferating;regeneration potential;Research;Resolution;Role;Scientist;senescence;senescent cell;senolytics;senomorphic;Technology;telomere;tissue mapping;Tissues;tool;transcriptome;transcriptomic profiling;transcriptomics;whole genome

PROJECT_TITLE: Spatial mapping senescent cells across the mouse lifespan by multiplex transcriptomics and epigenomics


NIH_SPENDING_CATS: Aging;Genetics;Human Genome

PI_NAMEs: ADAMS, PETER D. (contact)

PROJECT_TERMS: Acceleration;Adherence;Aging;Atlases;Benchmarking;Biological;Biological Assay;Bone Marrow;Brain;Breast;Cell Aging;Cell Separation;Cells;Cellular Assay;Cellular biology;Clinic;Collaborations;Colon;Communication;Data Analyses;Data Collection;Data Coordinating Center;data exchange;data sharing;Decision Making;Development;Ensure;Epigenetic Process;epigenome;epigenomics;equipment acquisition;experience;Experimental Designs;experimental study;flexibility;Funding;Goals;Group Meetings;Human;human tissue;Individual;Infrastructure;Institution;Leadership;life span;Liver;Malignant Neoplasms;Maps;meetings;member;Monitor;multimodality;Mus;Names;nano-string;operation;organizational structure;Performance;Persons;Policies;Procedures;Productivity;programs;Protocols documentation;Recording of previous events;Regulation;Reporting;Research;Research Activity;Research Personnel;Resolution;Resource Allocation;Resources;Role;senescence;senescent cell;Structure;Tissue Banks;tissue mapping;tissue preparation;tool;transcriptomics;Travel;United States National Institutes of Health;Validation

PROJECT_TITLE: Admin Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Prevention;Serious Mental Illness;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE  This research would contribute to fundamental knowledge about modifiable risks of Alzheimer’s disease (AD) and our capacity to potentially delay brain amyloid beta (Aβ) deposition that occurs in elderly with Major Depressive Disorder (MDD). To our knowledge, this will be the first project to explore the association between changes in depressive symptoms and changes in cerebrospinal fluid (CSF) Aβ levels, as well as plasma biomarkers of vascular dysfunction, which could potentially facilitate the development of novel therapeutic interventions to prevent the risk of AD.

PI_NAMEs: POMARA, NUNZIO  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: abeta deposition;Adult;Age;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Amyloid beta-Protein;anti-depressive agents;Biological;Biological Markers;Blood;Blood Platelets;Blood Vessels;Brain;cardiovascular risk factor;Cerebrospinal Fluid;Cerebrovascular Disorders;Clinical Trials;Cognitive;Cognitive deficits;cognitive testing;Data;Dementia;dementia risk;Deposition;depressive symptoms;Development;disorder risk;Double-Blind Method;effective therapy;Elderly;Epidemiology;Escitalopram;Etiology;Evaluation;Frequencies;geriatric depression;Goals;Homocysteine;Impaired cognition;in vivo;Individual;inflammatory marker;Knowledge;late life;Lead;life span;Link;Magnetic Resonance Imaging;Major Depressive Disorder;Measures;Mediating;Mediator;Mental Depression;mild cognitive impairment;MMP2 gene;MMP9 gene;modifiable risk;Monitor;Nature;novel therapeutic intervention;older adult;P-Selectin;Pathogenesis;Patients;Persons;Plasma;Platelet Activation;Population;Positron-Emission Tomography;prevent;prodromal Alzheimer's disease;Randomized;randomized placebo controlled study;reduce symptoms;Reporting;Research;research clinical testing;Residual state;response;Risk;Risk Factors;Risk Reduction;Selective Serotonin Reuptake Inhibitor;Severities;single episode major depressive disorder;Study models;Symptoms;tau Proteins;tau-1;Testing;treatment response;Vascular Diseases;White Matter Hyperintensity

PROJECT_TITLE: Depression treatment and Aβ dynamics: A study of Alzheimer’s disease risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-W(02)]


PROJECT_TERMS: Ablation;Address;Age;age-related disease;Aging;Architecture;Atlases;Biological;Biological Assay;Bone Marrow;Brain;Breast;Cell Aging;Cells;Cellular Assay;Characteristics;Chromatin;Collaborations;Colon;Data;Data Analyses;Data Set;Disease;DNA Methylation;drinking water;Epigenetic age;epigenome;epigenomics;Evaluation;Exhibits;Female;Functional disorder;Future;Gene Expression;Genetic;genetic approach;Genetic Markers;Goals;hallmarks of aging;Heterogeneity;Histone Deacetylase Inhibitor;histone modification;Human;Imaging technology;In Situ;Individual;Inflammatory;innovation;Knowledge;life span;Link;Liver;male;Maps;Measurement;Molecular;Molecular Profiling;Mouse Strains;multiple omics;Mus;Neighborhoods;old mice;Organ;pharmacologic;Phenotype;Population;Proliferating;protein biomarkers;Research;Resolution;senescence;senescent cell;senolytics;senomorphic;Technology;telomere;Tissue atlas;tissue mapping;Tissues;tool;transcriptome;transcriptomics;Vorinostat;whole genome;Work

PROJECT_TITLE: Bioanalysis Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Gene Therapy;Genetics;HIV/AIDS;Neurodegenerative;Neurosciences;Substance Misuse

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Eradication of HIV in latently infected cells is critical for a cure of HIV and HIV-associated neurocognitive disorders. This proposed research is relevant to public health because the discovery of a novel gene therapy targeting HIV-1 cellular reservoirs is ultimately expected to snip out integrated HIV provirus in the brain. Thus, the strategy to eradicate virus and save host cells in this proposal is relevant to NIH's mission to develop novel therapeutics for the permanent cure of HIV in the presence of substance use disorder.

PI_NAMEs: HU, WENHUI  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: adenovirus mediated delivery;Amino Acids;antiretroviral therapy;Astrocytes;Blood Vessels;blood-brain barrier crossing;blood-brain barrier penetration;Brain;Capsid;cDNA delivery;cell type;Cells;cellular transduction;Chronic;clinical application;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Complementary DNA;Cre lox recombination system;Data;Dependovirus;Devices;Disease;dosage;Endogenous Retroviruses;exosome;FDA approved;Gene Delivery;gene therapy;Gene Transfer;gene-targeted therapy;genome editing;genome editor;Goals;high reward;high risk;HIV;HIV-1;HIV-associated neurocognitive disorder;immunogenicity;In Vitro;in vivo;Injectable;Injections;Intravenous;intravenous administration;Link;Macrophage;Mediating;Messenger RNA;Microglia;Mission;Mus;Myeloid Cells;neuroAIDS;neurocognitive disorder;neuroinflammation;Neurons;Neuropathogenesis;novel;novel therapeutics;Outcome;Participant;particle;Peptides;Phase I Clinical Trials;Production;Proviruses;Public Health;Reporter;Research;response;Safety;Serotyping;Site;Substance Use Disorder;success;syncytin;System;Technology;Therapeutic;therapeutic development;Tissues;tool;Toxic effect;transduction efficiency;transgene expression;Transgenes;Transgenic Mice;Treatment Efficacy;United States National Institutes of Health;vector;Viral Packaging;Virus;Virus Latency

PROJECT_TITLE: Long-term microglia-targeted endogenous retrovirus-like particle (ERVLP) delivery of Cas12f editor to cure HIV


NIH_SPENDING_CATS: Aging;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: REN, BING  (contact)

PROJECT_TERMS: 3-Dimensional;age group;analytical method;analytical tool;Anti-Inflammatory Agents;Atlases;Back;Biological;Biological Assay;Bone Marrow;Brain;Brain Mapping;Breast;Candidate Disease Gene;Cell Aging;Cell model;cell type;Cells;Chromatin;chromatin modification;Chromosome Mapping;CISH gene;Collaborations;Colon;Communities;Computer software;Data;Data Analyses;Data Coordinating Center;Data Files;data format;data quality;data repository;Data Set;data sharing;data standards;DNA Methylation;Enhancers;Ensure;Epigenetic age;epigenome;epigenomics;Exhibits;experience;experimental study;FAIR principles;Female;file format;Gene Expression;Genes;Genetic;Genetic Markers;Genetic Transcription;genomic data;genomic signature;Genomics;Goals;Hepatocyte;Hippocampus;histone modification;Image;interoperability;life span;Link;Liver;Machine Learning;machine learning classifier;machine learning model;male;Maps;Metadata;Modeling;Molecular Conformation;molecular phenotype;mouse model;multiple omics;Mus;old mice;open source;Pathway interactions;pharmacologic;Phenotype;Population;Process;programs;promoter;public repository;Publishing;Recording of previous events;Regulation;Regulatory Element;repository;Reproducibility;Research Design;Resolution;Resources;senescence;senescent cell;senolytics;senomorphic;sex;single cell analysis;single cell genomics;single cell sequencing;Space Perception;Tissues;transcriptome;transcriptomics;validation studies;Work

PROJECT_TITLE: Data Analysis Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cervical Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Rare Diseases;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Due to disparities in healthcare access, women in rural America and other low-resource settings worldwide are twice as likely to die from cervical cancer as their urban and high-resource counterparts. We will develop a paper- based sample-to-answer test that provides sensitive and specific detection of high-risk pre-cancer and invasive cervical cancer at the point-of-care. This test will enable rapid screening and reduce barriers to same-visit treatment, ultimately reducing cervical cancer disparities by saving the lives of patients whose disease would have otherwise be missed.

PI_NAMEs: LINNES, JACQUELINE  (contact);MOHAMMED, SULMA IBRAHIM

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Acetic Acids;Antibodies;Area;beta Actin;Binding;Biological Assay;Biological Markers;Biomedical Engineering;Blinded;Buffers;cancer biomarkers;cancer health disparity;cancer invasiveness;Cancerous;Caring;Cause of Death;CDKN2A gene;Cell Culture Techniques;Cervical;Cervical Cancer Screening;Cervical Intraepithelial Neoplasia;Cessation of life;Characteristics;Clinical;clinical infrastructure;clinically relevant;Cold Therapy;Country;Cytology;Cytolysis;Death Rate;Detection;Development;Devices;Diagnostic;Disease;Disparity;Early Diagnosis;early screening;Ensure;Enzyme-Linked Immunosorbent Assay;Evaluation;Flowers;follow-up;Goals;Gynecologic Oncologist;health care availability;health care delivery;health care disparity;Health Personnel;Healthcare;high risk;high risk population;Horseradish Peroxidase;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papillomavirus;Human Resources;Immunoassay;Incidence;Income;infection rate;Infertility;Infrastructure;insight;instrumentation;Laboratories;Lesion;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Marketing;MCM2 gene;Methods;Monitor;mortality;multiplex detection;nanoGold;North Carolina;Outcome;overtreatment;Pap smear;Paper;Pathologist;Patients;Performance;performance tests;point of care;point of care testing;Policies;Predictive Value;premalignant;Premature Birth;Prevention;Primary Prevention;Process;programs;protein biomarkers;protein purification;Proteins;Rapid screening;Rare Diseases;Reagent;Receiver Operating Characteristics;Refrigeration;Resource-limited setting;Resources;Risk Reduction;risk stratification;Rural;rural America;sample collection;Sampling;scale up;Scientist;screening;Screening procedure;screening program;Sensitivity and Specificity;Signal Transduction;skills;Specialist;Specificity;Specimen;standard of care;Step Tests;Swab;Techniques;Technology;Testing;Time;TOP2A gene;tumor progression;two-dimensional;United States;Universities;Vaccines;valosin-containing protein;viral detection;Visit;Visual;Woman;World Health Organization;Zambia

PROJECT_TITLE: Point-of-care screening test for early cervical cancer detection

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Data Science;Disability Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety;Stroke

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE Preventable, intraoperative technical errors harm 16,000 patients in the United States each year, resulting in neurologic injury, stroke, and other disabilities in up to 70% and death in up to 16% of affected patients. Without a systematic data source and method describing intraoperative actions, interventions to prevent intraoperative errors during neurosurgery cannot be rationally designed and implemented. The proposed research seeks to address this problem by constructing a clinical and video dataset of neurosurgical video and patient data, using advanced machine learning and computer vision techniques to ‘watch’ recorded surgical video, automatically detect intraoperative actions, and predict upcoming adverse events using a model which integrates clinical data with surgeon movement metrics and visual features of the surgical field.

PI_NAMEs: DONOHO, DANIEL A. (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Address;Adverse event;adverse outcome;Affect;Anatomy;Architecture;Award;Cadaver;career;career development;Carotid Artery Injuries;Cerebrospinal Fluid;cerebrovascular;Cessation of life;Characteristics;Classification;Clinical;Clinical Data;Complex;Computer Vision Systems;Consensus;Data;Data Set;Data Sources;deep learning;design;Development Plans;disability;Discipline;Disease;Etiology;Evaluation;experience;Feedback;Foundations;Future;Goals;Hemorrhage;high risk;Human;improved;Institution;instrument;International;Intervention;Knowledge;Label;large datasets;Learning;Length;Machine Learning;machine learning algorithm;machine learning method;machine learning model;Measures;Medical Imaging;Memory;Mentors;Mentorship;Methods;Mission;Modeling;Movement;multimodal data;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Nervous System Trauma;neural network;neural network algorithm;Neurological disability;Neurosurgeon;neurosurgery;Operative Surgical Procedures;Outcome;Pathology;Patient-Focused Outcomes;Patients;Pattern;Performance;Perfusion;Persons;Phase;Pituitary Gland;Pituitary Neoplasms;post stroke;Postoperative Period;predictive modeling;prevent;Procedures;prospective;rational design;Research;research and development;Residual Neoplasm;Resources;Scientist;self-attention;simulation;skills;Standardization;Statistical Methods;Stroke;success;Surgeon;Surgical Error;surgical research;surgical risk;Techniques;Testing;therapy design;Time;Tissues;tool;Training;United States;Video Recording;Visual;visual learning;Visualization;Work

PROJECT_TITLE: Video Analysis of Neurosurgical Technical Performance and Adverse Events


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Ovarian cancer most frequently metastasizes to the adipocyte-rich omentum and recurrences most frequently occur at adipose tissue depots. In this project, we will investigate the effect of metabolic reprogramming before and after chemotherapy on immune function and therapy response.

PI_NAMEs: LENGYEL, ERNST  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Abdomen;Abdominal Cavity;Acetates;Adhesions;Adipocytes;adipokines;Adipose tissue;Adjuvant Chemotherapy;Biochemical;Biological Assay;Biology;cancer cell;Cancer Patient;Cause of Death;cell type;Cellular Assay;Characteristics;Chemoresistance;chemotherapy;confocal imaging;Data;defined contribution;Disease;Effector Cell;Epithelium;exhaustion;experience;Fibroblasts;Glucose;Immune;Immune checkpoint inhibitor;immune function;Immunotherapy;In Vitro;in vivo;insight;Intra-abdominal;Invaded;Label;Laboratories;Lipids;long chain fatty acid;Macrophage;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;mass spectrometric imaging;Metabolic;Metabolism;metabolomics;Methods;Methyltransferase;migration;mouse model;Natural Killer Cells;Neoadjuvant Therapy;Neoplasm Metastasis;Omentum;Operative Surgical Procedures;Organ;oxidation;Patients;Primary Neoplasm;Process;Production;Recurrence;research clinical testing;Resistance;Role;screening;small molecule inhibitor;Stromal Cells;Structure;T-Lymphocyte;Testing;therapy resistant;three dimensional cell culture;treatment response;tumor;tumor microenvironment;tumor progression;Tumor Tissue;Visceral

PROJECT_TITLE: Metabolic reprogramming of the tumor microenvironment and therapy resistance


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Social Determinants of Health

ORG_CITY: MADISON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE We propose a new undergraduate research education program, NextGenPop, which aims to significantly increase the pipeline of scholars from underrepresented backgrounds entering the field of population science. It is a collaborative initiative that mobilizes five leading universities to train advanced undergraduate students in contemporary population research and demographic analysis though a brief but intensive summer residential program and ongoing remote and in-person follow-up. This effort will ultimately advance the body of demographic and public health knowledge to more fully reflect the diversity of human populations today.

PI_NAMEs: CARLSON, MARCIA JEANNE (contact);MUSICK, KELLY

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Address;Advisory Committees;Ally;Applied Research;Attention;career;Career Mobility;Child Health;cohort;critical period;Data;Data Analyses;data tools;Demographic Analyses;Demography;Development;Doctor of Philosophy;education research;Educational Curriculum;Ensure;Environment;ethnic diversity;experience;Faculty;Family;follow-up;Fostering;Future;Geographic Locations;Government;graduate school preparation;Growth;Health;health knowledge;Human;Human Development;Individual;Inequality;Infrastructure;insight;Institution;Knowledge;Learning;lens;marginalization;meetings;member;Methodology;Methods;Minnesota;Mission;next generation;Participant;Pattern;peer support;Personal Satisfaction;Persons;Policies;Population;Population Process;Population Research;Population Sciences;Process;Productivity;Professional Organizations;Program Development;programs;Public Health;racial diversity;recruit;Research;Research Personnel;Resources;Rotation;Science;Shapes;Site;Structure;student training;Students;study population;success;summer program;Techniques;tool;Training;undergraduate research;undergraduate student;Underrepresented Students;Universities;virtual;Visualization;Wisconsin

PROJECT_TITLE: NextGenPop: Recruiting the Next Generation of Scholars into Population Research


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The most common form of hearing loss is caused by the death of hair cells in the cochlea. Young mammals are capable of regenerating some hair cells, but this ability disappears by the time they are old enough to hear. In our proposal, we will use genetic reprogramming to drive cells of the inner ear to produce new hair cells, and to understand the mechanisms through which this reprogramming can happen in clinically-relevant conditions.

PI_NAMEs: GROVES, ANDREW K (contact);RAPHAEL, YEHOASH

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Acute;Affect;age related decline;Alleles;animal old age;Animals;Cause of Death;Cells;Chronic;Clinical;clinically relevant;Cochlea;comparative efficacy;Complement;Consensus;Data;deaf;deafening;deafness;Ear;Ectopic Expression;Embryo;Engineering;Environment;Epigenetic Process;Epithelium;experimental study;feasibility testing;Future;Genes;Genetic;Genetic Engineering;Genetic Transcription;GFI1 gene;guinea pig model;hair cell regeneration;Hair Cells;Hearing;hearing impairment;Human;improved;Injury;Intervention;Labyrinth;Mammals;Minority;Morphology;Mus;Natural regeneration;Neonatal;Organ of Corti;Pathology;Patients;regeneration potential;regenerative;regenerative approach;Regenerative capacity;response;Sensorineural Hearing Loss;Severities;success;Supporting Cell;Testing;Therapeutic;Time;Tissues;transcription factor;transcriptomics;transdifferentiation;Transgenic Organisms;Type II Hair Cell;Utricle structure;Vertebrates;vestibular system

PROJECT_TITLE: Enhancing Atoh1 function in hair cell regeneration

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: BIRMINGHAM

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The proposed research is highly relevant to public health because identification of the Parkinson’s disease (PD) patients at a high-risk for developing dementia (PDD) is critical for better prognostication, correct identification of PDD in its prodromal stage to recruit in new disease-modifying clinical trials, and to better understand the pathophysiological processes underlining PDD. The proposed project identifies the best predictive biomarkers for PDD through examining the comprehensive Gaussian and non-Gaussian diffusion-MRI (dMRI)-derived white matter (WM) changes predicting PDD, examining the network-level discrepancies predicting PDD derived from dMRI-derived whole-brain structural connectivity and resting-state functional MRI (rsfMRI)-derived whole-brain functional connectivity, and developing a multivariate and multimodal statistical model by combining these sophisticated pathologically relevant neuroimaging measures with non-imaging measures such as clinical (disease duration and severity), demographics (age, sex, years of education), genetics (LRRK2), and CSF- measures (β-Amyloid, α-Synuclein, tau) to identify the best predictive biomarkers of PDD through machine learning approach. The machine learning algorithm developed in our proposal also has great potential for significantly advancing the understanding of other neurodegenerative disorders such as Alzheimer’s disease (AD) thereby helping to understand AD- and PD-specific neuroanatomical changes predicting dementia.

PI_NAMEs: MISHRA, VIRENDRA R (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: accurate diagnosis;Age;alpha synuclein;Alzheimer's Disease;Amyloid beta-Protein;Anatomy;Biological Markers;biomarker identification;Brain;Classification;Clinical;Clinical Trials;Cognition;cognitive impairment in Parkinson's;cohort;Complex;Data;data acquisition;Dementia;demographics;density;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;disorder subtype;Education;Fiber;Functional disorder;Functional Magnetic Resonance Imaging;Genetic;Goals;gray matter;high risk;illness length;Image;Impaired cognition;LRRK2 gene;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Measurement;Measures;Methods;mild cognitive impairment;misfolded protein;Modality;Modeling;Monitor;multimodality;Neurites;Neuroanatomy;Neurodegenerative Disorders;neuroimaging;Neuropsychology;novel;Parkinson Disease;Parkinson's Dementia;Pathologic;Patients;Pattern;Physiological Processes;pre-clinical;predictive marker;prion-like;Process;prognostication;progression marker;Public Health;rapid eye movement;recruit;Research;Resolution;Rest;Risk;Severity of illness;sex;Statistical Models;tau Proteins;Time;tool;transmission process;Validation;Variant;Water;white matter;white matter change

PROJECT_TITLE: Towards Generating a Multimodal and Multivariate Classification Model from Imaging and Non-Imaging Measures for Accurate Diagnosis and Monitoring of Dementia in Parkinsons disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Cannabinoid Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Natural Products;Substance Misuse;Therapeutic Cannabinoid Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE HIV-1 infection causes chronic inflammation in HIV-infected persons who have high rates of substance abuse. This study will evaluate the role of cannabinoids in HIV-mediated inflammasome signaling in lymphoid tissue. This study will inform mechanisms of pathogenesis and novel therapeutic advances to improve the outcomes of HIV-infected persons.

PI_NAMEs: SWARTZ, TALIA H (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: Anti-Inflammatory Agents;antiretroviral therapy;Bioinformatics;Biological Markers;cannabinoid receptor;cannabinoid treatment;Cannabinoids;Cannabis;career;career development;CD4 Positive T Lymphocytes;Cell Death;cell type;Cells;cellular imaging;cellular targeting;Central Nervous System;Chronic;cohort;Colitis;comorbidity;Core Facility;Data;Disease;Dissociation;DNA;drug development;drug of abuse;Exhibits;experience;Gene Expression;Genomics;Goals;Health system;HIV;HIV-1;Human;Immune;Immunology;immunoregulation;Impaired cognition;improved outcome;Individual;Infection;Inflammasome;Inflammation;Inflammatory;insight;Institution;interest;Interleukin-1 beta;Link;Lymphoid Tissue;Macaca;Macrophage;Mediating;Mediator;medical schools;Methods;migration;Modeling;Molecular;Myocardial Infarction;novel;novel strategies;novel therapeutics;Operative Surgical Procedures;Pathogenesis;Pathway interactions;Patients;Peripheral;peripheral blood;Persons;pharmacologic;Physicians;pleiotropism;polysubstance abuse;Premature aging syndrome;Principal Investigator;Property;receptor;Receptor Activation;Receptor Signaling;Recommendation;Research Personnel;response;Role;Scientist;sensor;Signal Transduction;SIV;Substance abuse problem;Testing;Therapeutic Agents;Tissues;Tonsil;Tonsillar Tissue;transcriptomics;Viremia;virology

PROJECT_TITLE: Elucidating the mechanisms of cannabinoids on HIV-1 infection and inflammasome activation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-F(50)R]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Genetics;Human Genome;Pediatric

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Gene editing technologies have progressed rapidly in humans and several efforts at clinical translation are ongoing. Recent experiments in translation in reproductive settings have emphasized the need for more values based and patient-centered governance mechanisms for translation of prenatal gene editing. We propose to conduct empirical and deliberative research to inform a governance structure that is in alignment with patient and clinician priorities.

PI_NAMEs: ALLYSE, MEGAN A. (contact);ISASI, ROSARIO

PROGRAM_OFFICER_NAME: LOCKHART, NICOLE C

PROJECT_TERMS: Acceleration;Address;advocacy organizations;Affect;Age of Onset;Agreement;Animal Model;aspirate;Assisted Reproductive Technology;Attention;Attitude;Birth;Child;China;Clinical;clinical application;clinical practice;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Communities;community engaged research;community partners;Consensus;Country;deliberative democracy;design;Development;Disease;disease-causing mutation;Embryo;Emerging Technologies;Empirical Research;Ethics;Event;Exercise;experimental study;falls;Family;Family member;Fetus;Future;Gene Delivery;gene editing technology;Genes;Genetic;Genetic Diseases;Genetic Medicine;genetic technology;Germ Lines;Goals;Government;Heritability;Human;Impaired cognition;in utero;In Vitro;Income;Individual;informant;Infrastructure;innovation;International;Interview;Left;Literature;Mediating;member;Methods;Modeling;Mutation;novel;Participant;Pathway interactions;Patient advocacy;patient oriented;patient population;Patient Representative;Patients;Penetrance;permissiveness;physical impairment;Policies;Policy Maker;prenatal;prenatal intervention;Prenatal Structures;pressure;Process;Professional Organizations;Professional Self Regulation;progenitor;Protocols documentation;Published Comment;Qualitative Research;recruit;Regenerative Medicine;Regulation;Reporting;reproductive;Reproductive Sciences;Research;Risk;Safety;Sampling;Science;Science Policy;Scientist;Severities;Social Values;Source;Structure;Support Groups;symposium;System;Technology;tool;translational potential;Translations;United States;United States Food and Drug Administration;Voice;Work

PROJECT_TITLE: PaSAGE: PAtient Supported Approaches to Gene Editing


ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative Cellular differentiation is the process through which individual stem cells generate a multitude of cell types, each with distinct form and function. The proposed project aims to illuminate the mechanisms that drive differentiation through data-driven modeling of high-throughput single-cell data. A comprehensive understanding of such mechanisms will provide a basis to decipher the dysregulation in disease and significantly boost the potential of cell engineering to produce treatment-grade cells and tissues.

PI_NAMEs: SETTY, MANU N (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Algorithms;ATAC-seq;Biological Process;Biology;Cell Communication;Cell Differentiation process;cell type;Cells;cellular engineering;Chromatin;Complex;Computer Models;Data;Data Set;data-driven model;Disease;embryo cell;Enhancers;Event;Genetic Transcription;Heterochromatin;Homeostasis;in vivo;Individual;insight;Life;Measurement;Modeling;multimodality;Natural regeneration;novel;Organism;Phenotype;Process;Research;Role;Shapes;Signal Transduction;single-cell RNA sequencing;spatiotemporal;stem cells;Technology;Therapeutic;Tissues;Transcriptional Regulation;transcriptome sequencing;transmission process;wound healing

PROJECT_TITLE: Computational Modeling of Lineage Decisions using Single-cell Data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Molecular based blood tests provide an accessible and affordable option for screening high risk populations for many common cancers, leading to early detection with better outcomes. We propose to study the origins and molecular characteristics of cell-free DNA fragments in pre-neoplastic lung lesions and in treatable lung tumors with the aim of improving not only the ability to detect small early lesions, but also to identify which lesions are likely to progress to cancer. Through optimization of our molecular test in plasma, we plan to test and validate our approach in both accrued samples and a prospective lung cancer screening population.

PI_NAMEs: SIDRANSKY, DAVID ;VELCULESCU, VICTOR E. (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Adenocarcinoma;ATAC-seq;Benign;biomarker development;biomarker identification;Blood;Blood Tests;cancer biomarkers;cancer classification;Cancer Detection;cancer genomics;cancer invasiveness;Cancer Patient;carcinogenesis;case control;cell free DNA;Cells;Characteristics;Chromatin;Clinical;clinical application;cohort;Collaborations;computed tomography screening;cost;Data;Data Analyses;data integration;deep sequencing;Detection;detection sensitivity;Development;Disease;DNA;DNA Fragmentation;DNA Markers;DNase I hypersensitive sites sequencing;Early Detection Research Network;Early Diagnosis;epigenome;epigenomics;Evaluation;Event;Frequencies;Futility;Gene Expression;General Population;Genome;genome sequencing;genome-wide;Genomics;Hematopoietic;Hi-C;high risk population;improved;Incidence;Individual;insight;Intervention;Lesion;Leukocytes;liquid biopsy;Localized Malignant Neoplasm;Lung;lung cancer screening;lung lesion;Lung Neoplasms;Lung nodule;lung tumorigenesis;Machine Learning;machine learning model;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Methylation;Modeling;Molecular;Multiomic Data;neoplastic;Nodule;Non-Invasive Lesion;noninvasive diagnosis;Normal tissue morphology;novel;Nucleosomes;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Performance;Phase;Plasma;Population;premalignant;Process;prospective;Research;Sampling;screening;Screening for cancer;Sensitivity and Specificity;Specimen;Spiral Computed Tomography;Statistical Data Interpretation;Testing;Tissues;tool;Training;transcriptome;transcriptome sequencing;Translating;tumor;tumor progression;tumorigenesis;Variant;whole genome

PROJECT_TITLE: DNA evaluation of fragments for early interception (DELFI) of Lung cancer


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project narrative Alterations in the nonspecific thalamus, a brain region crucial for consciousness, are recently implicated in the morphine effects and addictive disorders. Thus, resolving the mechanisms that regulate its activity is an important task in the pursuit of novel drug targets. This research proposal will provide the first comprehensive study on the role of T-type calcium channels in the nonspecific thalamus in the function of the morphine-mediated effects and opioid addiction, using ex vivo recordings of neuronal activity and behavioral experiments, coupled with a sophisticated genetic approach, thereby identifying these channels as a potential drug target for opioid use disorder.

PI_NAMEs: TIMIC STAMENIC, TAMARA  (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Acute;addiction;Addictive Behavior;Amygdaloid structure;Anesthesia procedures;Anesthesiology;Animal Behavior;Animal Model;Anterior;Behavior;Behavioral;Behavioral Model;biophysical properties;Brain;Brain region;Calcium;Calcium Channel;Calcium Channel Blockers;Calcium ion;Cells;Central Medial Thalamic Nucleus;Claustral structure;Closure by clamp;Colorado;conditioned place preference;Conscious;Corpus striatum structure;Coupled;Data;Disease;Drug abuse;Drug Addiction;drug reward;Drug Targeting;Education;Electrophysiology (science);experimental study;FOS gene;FOS Protein;Foundations;Genetic;genetic approach;Goals;Image;in vivo;Injections;insight;interest;Intralaminar Nuclear Group;knock-down;Knock-out;Knowledge acquisition;Laser Scanning Microscopy;Medial Dorsal Nucleus;Mediating;Mentors;Mentorship;Methods;Modeling;Molecular;Morphine;motivated behavior;mouse genetics;mu opioid receptors;neuronal excitability;Neurons;new therapeutic target;novel;novel strategies;novel therapeutics;Nucleus Accumbens;Olfactory tubercle;Opiate Addiction;Opioid;Opioid Analgesics;opioid overuse;opioid use disorder;Overdose;overdose death;Pain;patch clamp;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;Play;Positioning Attribute;Preparation;Prevention;Principal Investigator;Process;Property;Protein Isoforms;putamen;Regulation;Research;Research Personnel;Research Proposals;Resources;Role;Self Administration;skills;Slice;small hairpin RNA;Stimulus;T-Type Calcium Channels;Technology;Testing;Thalamic structure;Tissues;Training;two-photon;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities;Viral;voltage

PROJECT_TITLE: The role of T-type calcium channels in the morphine effects in the nonspecific thalamus

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE Diffuse intrinsic pontine gliomas (DIPGs) are highly lethal pediatric brain tumors and a leading cause of cancer- related deaths in children. Chimeric antigen receptor (CAR) T-cell immunotherapy has the potential to improve outcomes in adult and pediatric patients with brain tumors; however, CAR design must be optimized and carefully evaluated in DIPG mouse models that closely mimic human disease. In this study, we propose to enhance CAR T–cell efficacy for DIPGs by optimizing the CAR co-stimulatory domain, silencing the negative T-cell regulators, and defining the inhibitory mechanisms in the DIPG tumor immune microenvironment that are activated by CAR T–cell treatment.

PI_NAMEs: KRENCIUTE, GIEDRE  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Ablation;Address;Adoptive Transfer;Adult;Affect;antigen-specific T cells;Antigens;Antitumor Response;Brain Neoplasms;cancer cell;Cancer Etiology;CAR T cell therapy;CD276 gene;CD28 gene;Cell Communication;Cell Line;Cell Physiology;Cell surface;Cell Therapy;Cells;Cellular biology;Child;Childhood Brain Neoplasm;childhood cancer mortality;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Research;clinically relevant;CRISPR screen;cytokine;Data;design;Development;Diffuse intrinsic pontine glioma;diffuse midline glioma;disease model;effective therapy;effector T cell;efficacy evaluation;Endoplasmic Reticulum;endoplasmic reticulum stress;engineered T cells;Engineering;eosinophil;Evaluation;exhaustion;experience;Flow Cytometry;Frequencies;Gene Deletion;Genes;genome wide screen;genome-wide;glucose-regulated proteins;Goals;Golgi Apparatus;GRP78 gene;Human;human disease;Immune;immune cell infiltrate;Immune response;Immunocompetent;immunodeficiency;Immunooncology;Immunotherapy;improved;improved outcome;In Vitro;in vitro activity;in vivo;innovative technologies;Intervention;Intrinsic factor;Knock-out;Knowledge;Literature;Macrophage;Mediating;Methods;Modeling;Molecular;Molecular Target;monocyte;mouse model;Mouse Strains;multidisciplinary;Mus;Myeloid Cells;neoplastic cell;novel;novel therapeutics;Outcome;Pathway interactions;Patients;pediatric patients;Phase;Phenotype;Population;pre-clinical;Proteins;prototype;Publishing;response;Role;Safety;safety testing;Signal Pathway;single-cell RNA sequencing;Solid Neoplasm;Subgroup;Surface;T-Cell Activation;T-Cell Receptor;T-Cell Receptor Therapy;T-Lymphocyte;Testing;TNFRSF5 gene;tool;Translations;tumor;Tumor Antigens;tumor heterogeneity;tumor-immune system interactions;Xenograft Model

PROJECT_TITLE: GENETICALLY ENGINEERED T CELLS FOR DIPG

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE About 12% of reproductive aged women of all marital statuses in the US have impaired fecundity - with increasing age, ovulatory disorders, endometriosis, and tubal factor as leading causes. Those who conceive spontaneously or with fertility therapies are at increased risk of adverse pregnancy outcomes due mainly to implantation and placenta disorders. Our Center for Research, Innovation and Training in Reproduction and Infertility at UCSF brings together expertise in clinical medicine, basic and translational science, and advanced technologies focused on the inter-related roles of endometrial inflammation, epigenetics, and development as determinants of early pregnancy outcomes and provides a rich environment for trainees and outreach to the community about innovations in reproductive science and medicine.

PI_NAMEs: ERLEBACHER, ADRIAN  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: accurate diagnostics;Address;adverse pregnancy outcome;Affect;Age;aged;Antigens;B-Lymphocytes;Basic Science;Biological Models;California;career;Cells;Center for Translational Science Activities;Chorion;Chorionic Sac;Clinical;Clinical Medicine;clinically relevant;Communities;community engagement;Conceptus;Couples;Decidua;design;Development;Developmental Process;Diagnostic;Discipline;Disease;diversity and inclusion;early pregnancy;early pregnancy loss;Education;Education and Outreach;embryo tissue;Endometrial;endometriosis;Endometrium;Environment;Epigenetic Process;experience;Failure;Female;Female infertility;Fertility;fetal;Fetal Growth Retardation;Fetal Membranes;Fostering;Funding;Future Generations;Genomics;Goals;Health;health science research;Human;Immunologics;Impairment;Implant;implantation;Infertility;infertility treatment;Inflammation;Inflammation Mediators;Inflammation Process;Inflammatory;innovation;insight;Institution;interdisciplinary collaboration;Investigation;literacy;Lymphocyte;Marital Status;Maternal-Fetal Exchange;Medicine;member;Mentors;Mentorship;Molecular;Morbidity - disease rate;multiple omics;novel;offspring;Outcome;outreach;Pathologic;Pathology;Personal Satisfaction;personalized medicine;Phenotype;Pilot Projects;Placenta;Placenta Diseases;Polycystic Ovary Syndrome;Positioning Attribute;Pre-Eclampsia;Pregnancy;Pregnancy Outcome;Pregnant Women;preimplantation;Premature Birth;Process;Quality of life;Reproduction;reproductive;Reproductive Health;Reproductive Medicine;reproductive outcome;Reproductive Sciences;reproductive success;Research;Research Personnel;Research Project Grants;Risk;Role;San Francisco;Science;Scientist;Specificity;Specimen;Stromal Cells;Students;Subfecundity;subfertility;success;T-Lymphocyte;targeted treatment;Technology;Time;Training;translational approach;Translational Research;trophoblast;United States National Institutes of Health;Universities;Uterus;Villous;Woman;Work;World Health Organization

PROJECT_TITLE: Immunological, epigenetic and developmental determinants of early pregnancy success


PROJECT_TERMS: Administrator;Award;Center for Translational Science Activities;Collaborations;Communication;Complex;cost effectiveness;Development;Doctor of Medicine;Doctor of Philosophy;early pregnancy;Education;Ensure;Epigenetic Process;Expenditure;experience;Faculty;Funding;Goals;Guidelines;Health Insurance Portability and Accountability Act;Home;Immunologics;Infertility;Infrastructure;Institution;Interdisciplinary Study;Laboratories;Medicine;meetings;member;Mentors;novel;operation;Personnel Management;Pilot Projects;programs;Regulation;Reproduction;Reproductive Sciences;Research;Research Personnel;Research Project Grants;Resources;success;Talents;Translational Research;United States National Institutes of Health;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Endometriosis;Genetics;Human Fetal Tissue;Human Genome;Infertility;Obesity;Polycystic Ovary Syndrome (PCOS);Pregnancy;Women's Health Research

PI_NAMEs: HUDDLESTON, HEATHER G (contact)

PROJECT_TERMS: Address;Allografting;Antigens;Archives;Autoantigens;Autoimmune;B cell therapy;B-Lymphocytes;Beds;CD8-Positive T-Lymphocytes;Cell Line;Cell Lineage;Cell Physiology;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chronic;comorbidity;CRISPR/Cas technology;Data;Decidua;Decidual Cell;Development;Developmental Process;Diagnostic;Disease;early pregnancy;early pregnancy loss;Endometrial;endometriosis;Endometrium;Ensure;Environment;Epigenetic Process;Epithelial Cells;Event;experimental study;failure Implantation;Female;Fertility;fetal;Fetal Development;Fibroblasts;First Pregnancy Trimester;Fostering;Frequencies;Genes;Goals;Human;Immune;Immunologics;immunoregulation;Impairment;implantation;improved;Infection;Infertility;Inflammation;Inflammatory;insight;Invaded;Knowledge;Lymphocyte;Lymphocyte Function;Lymphocyte Subset;Maternal-Fetal Exchange;Mediating;Mediator;Menstrual cycle;microbial;Modeling;natural Blastocyst Implantation;Natural Killer Cells;novel;obese patients;Obesity;Pathogenesis;Pathway interactions;Patients;Peptides;Phase;Phenotype;Placentation;Polycystic Ovary Syndrome;Population;Pregnancy;Pregnancy Outcome;Process;prospective;Proteome;Regulatory T-Lymphocyte;Reproduction;reproductive;reproductive outcome;reproductive success;Role;single cell technology;single-cell RNA sequencing;Specificity;Specimen;Spiral Artery of the Endometrium;Stains;subfertility;Subgroup;success;System;T-Cell Immunologic Specificity;T-Lymphocyte;Therapeutic;Thinness;Tissues;transcriptome;trophoblast;Uterus;Vascular remodeling;Villous;Woman;Work

PROJECT_TITLE: Lymphocyte function in inflammatory disorders of human endometrium and decidua


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Narrative Autism spectrum disorder (ASD) is a neurodevelopmental disorder with deficits in two core domains: social interaction and communication, and repetitive behaviors or restrictive behaviors. Mutations in many genes are associated with ASDs. This research project aims to discover a common pathophysiology induced by these mutations, which will provide invaluable information for development of effective therapies of ASD.

PI_NAMEs: RUMBAUGH, GAVIN R;XU, BAOJI  (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Affinity Chromatography;Androgens;Apoptosis;Appearance;Astrocytes;autism spectrum disorder;barrel cortex;Behavior;Behavior Disorders;Behavioral;boys;brain cell;Cd68;cell growth;Cephalic;Cognitive deficits;communication behavior;comparison control;Data Set;Dendritic Spines;density;Development;Diagnosis;Disease;dosage;effective therapy;Estradiol;Etiology;Eukaryotic Initiation Factors;Female;Functional disorder;Genes;girls;Gonadal Hormones;Gonadal Steroid Hormones;Hormone Receptor;Image;imaging study;Impairment;In Vitro;in vivo;in vivo imaging;Induced Mutation;Injury;Innovative Therapy;insight;Knock-in Mouse;Label;Lead;male;Messenger RNA;Microglia;Molecular;Monitor;Morphology;Motility;Mouse Strains;Mus;Mutation;neural circuit;Neurodevelopmental Disorder;Neuronal Dysfunction;Neurons;overexpression;Pathologic;Patients;Perinatal;Phenotype;Process;Proliferating;Protein Biosynthesis;Proteins;PTEN gene;repetitive behavior;Research Project Grants;response;Ribosomes;risk variant;Role;sex;Sex Chromosomes;sex determination;sexual dimorphism;Social Interaction;sry Genes;Synapses;Testing;Testis;Testosterone;transcriptome;transcriptome sequencing;Translating;Translations;TSC1 gene;TSC2 gene;Vertebral column;Viral;X Chromosome;Y Chromosome

PROJECT_TITLE: Molecular and cellular basis for autism spectrum disorders caused by exacerbated translation


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

PHR: Project Narrative: Pancreatic cancer is highly lethal and current treatments such as chemotherapy and radiation are only minimally effective due to its profound therapeutic resistance. This proposal seeks to build on prior work from our group exploring metabolic dependencies in pancreatic cancer to understand how metabolic adaptations through cell autonomous and non-cell autonomous mechanisms are integrated to allow for continued growth in an austere tumor microenvironment. The results of these studies may have an important impact on the treatment of this disease.

PI_NAMEs: KIMMELMAN, ALEC  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Amaze;Carbon;Cause of Death;Cell Survival;cell type;Cells;Chemotherapy and/or radiation;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Custom;Dependence;design;Disease;DNA Sequence Alteration;Environment;Equilibrium;Fibroblasts;Genetic;genetic signature;Glutamine;Growth;in vivo;in vivo evaluation;in vivo Model;Knowledge;KRAS oncogenesis;Libraries;Malate-Aspartate Shuttle Pathway;Malates;malic enzyme;Malignant neoplasm of pancreas;Metabolic;Metabolic Pathway;Metabolism;mouse model;Mus;NADP;neoplastic cell;Neurons;novel;Nutrient;Oncogenes;Oxidation-Reduction;Oxygen;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;Pathway interactions;pharmacologic;Population;Production;programs;Pyruvate;Refractory;Research;response;Role;Source;Stromal Cells;System;Therapeutic;therapeutically effective;therapy resistant;Tracer;tumor;tumor metabolism;tumor microenvironment;Work

PROJECT_TITLE: Identifying Metabolic Dependencies of Pancreatic Cancers


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Neurosciences;Nutrition

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: NARRATIVE Type 2 diabetes (T2D) is a common disorder with a complex etiology that remains incompletely understood. In 2016, we demonstrated that in rodent models of T2D, normoglycemia can be restored for weeks or months in rodent models of T2D by central administration of fibroblast growth factor 1 (FGF1). With support from this program, insight into underlying mechanisms has grown considerably since then, and convergent findings point to a key role for AgRP neuron inhibition as a key mediator of FGF1 effects on both food intake and glucose metabolism. Proposed studies will investigate the roles played by distinct AgRP neurons projections and signaling molecules in FGF1-induced feeding and metabolic control, and identify mechanisms underlying sustained inhibition of these neurons by FGF1.

PI_NAMEs: SCHWARTZ, MICHAEL W (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;Agonist;Analgesics;Anorexia;anorexic;Anti-diabetic Drugs;ART protein;Blood Glucose;blood glucose regulation;Brain;Calcitonin Gene-Related Peptide;Clinic;Complex;Data;Diabetes Mellitus;diabetes mellitus therapy;diabetic;Disease;Disease remission;Dose;Eating;Electrophysiology (science);Etiology;Extracellular Matrix;feeding;FGF1 gene;Fibroblast Growth Factor Receptors;FOS gene;GABA Agonists;GABA-A Receptor;gamma-Aminobutyric Acid;Glucose;glucose metabolism;Goals;Hyperglycemia;Hypothalamic structure;Injections;insight;Intake;Intervention;Investigation;Islets of Langerhans;Light;Liquid substance;Macaca mulatta;Malaise;Mediating;Mediator;Melanocortin 4 Receptor;Metabolic;Metabolic Control;Methods;Microinjections;Modeling;Neurons;Non-Insulin-Dependent Diabetes Mellitus;Paper;parabrachial nucleus;Peptides;pharmacologic;Physiological;Pilot Projects;Play;prevent;Primates;programs;Publishing;receptor;Remission Induction;Reporting;response;Rodent Model;Role;Secondary to;Series;Signal Transduction;Signaling Molecule;Stains;Structure of nucleus infundibularis hypothalami;Testing;transcriptomics;Translating

PROJECT_TITLE: Divergent Mechanisms Underlying Anorexic and Antidiabetic Actions of FGF1 in the Brain

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Osteoarthritis;Physical Injury - Accidents and Adverse Effects

ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Degenerative and post-traumatic osteoarthritis are human diseases with high impact on US public health, with increasing economic relevance due to a non-linear increase in prevalence. Here, we propose to extend our recent discovery of PIEZO mechanically-sensitive ion channels’ role in mechanically-induced injury of chondrocytes, the cellular element of cartilage, by addressing the questions how – mechanistically – PIEZO channels function in chondrocytes, how they function in inflammatory conditions that mimic osteoarthritis, how they function in live animals, and how their function can be attenuated toward a disease-modifying therapy.

PI_NAMEs: GUILAK, FARSHID  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Address;Affect;Age;Age Years;Aging;anakinra;Animals;antagonist;Anti-Inflammatory Agents;arthropathies;articular cartilage;ATF2 gene;Attenuated;attenuation;Binding;Biochemical;biological adaptation to stress;Body Weight;Cartilage;Cartilage injury;Cell model;Cells;Chondrocytes;chondroprotection;Complex;Coxibs;cytokine;Degenerative polyarthritis;Dependence;Development;disability;Disease;Dynamin;economic impact;Economics;Electrophysiology (science);Elements;Environment;experimental study;Exposure to;Family suidae;frailty;Friction;Gene Expression;Gene Expression Regulation;Genetic Transcription;Grant;Health;HNF4A gene;Human;human disease;human old age (65+);Hypersensitivity;IL1R1 gene;in vivo;Inflammation;Inflammatory;inhibitor;Injury;insight;Interferons;Interleukin-1 alpha;Ion Channel;joint injury;joint loading;Joints;Life;Link;loss of function;mechanical force;mechanical properties;mechanical signal;Mechanical Stress;Mechanics;mechanotransduction;Mediating;meloxicam;Membrane;Metabolic;Methods;Modeling;Morphology;Mus;Non-Steroidal Anti-Inflammatory Agents;Obesity;osteochondral tissue;Pain;Pathogenesis;Pathologic;Pathway interactions;Pharmaceutical Preparations;Phenotype;Physiological;Piezo 1 ion channel;Piezo 2 ion channel;Piezo ion channels;Population;Prevalence;Process;promoter;Public Health;radiological imaging;response;response to injury;Role;Signal Transduction;skeletal;Social isolation;Societies;socioeconomics;Surface;synergism;Synovial joint;Testing;Therapeutic;trafficking;transcription factor;Trauma;Traumatic Arthropathy;United States;voltage

PROJECT_TITLE: Deconstructing Cartilage Mechanotransduction by Piezo Channels

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Human Fetal Tissue;Human Genome;Infertility;Maternal Health;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_STATE: CA

PROJECT_TERMS: Acute;Affect;Biopsy;Blood;Cells;Cleavage Under Targets and Release Using Nuclease;Code;Conceptus;Decidua;Decidual Cell Reactions;Development;Disease;early experience;early pregnancy;Endometrial;Endometrial Stromal Cell;endometriosis;Epigenetic Process;epigenetic silencing;Etiology;experimental study;EZH2 gene;female fertility;Fibroblasts;First Pregnancy Trimester;Fostering;Gene Expression;Gene Silencing;Generations;Genes;Genetic;genome-wide;genomic locus;histone modification;Histones;Human;Immune;Immune response;Immunologics;immunoreaction;Impairment;implantation;imprint;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;insight;Knowledge;Laboratory Study;Leukocytes;Macrophage;Maternal-Fetal Exchange;Methylation;Methyltransferase;Modeling;mouse model;Mus;neutrophil;Pathology;Pathway interactions;Patients;Peripheral;Phenotype;Placenta;Placentation;Play;Pregnancy;pregnancy failure;Pregnancy Outcome;preimplantation;prevent;promoter;Proteins;Protocols documentation;Reaction;recruit;Regulation;Regulatory Pathway;response;Role;Sampling;Specimen;Stromal Cells;success;T-Cell Activation;T-Lymphocyte;Techniques;Testing;Time;Tissues;Uterus;Woman;Work;wound healing

PROJECT_TITLE: Epigenetics of decidual inflammation


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: There is an urgent need to understand how diabetes and elevated blood sugar levels impacts health and risk of complications. This project aims to answer this question by using large-scale biobank data and genetic analyses to discover genes that increase risk and enhance the biological insights of complications of diabetes. Such insights into complications of diabetes may guide development of potential clinical predictors, strategies for prevention and novel drug targeted towards for treatment and prevention of risk of complications of diabetes.

PI_NAMEs: SALEM, RANY  (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Adult;Affect;Albuminuria;American;Amputation;biobank;Biological;Biology;Blindness;Blood Glucose;Blood Vessels;Cessation of life;Classification;clinical predictors;comorbidity;Complex;Complications of Diabetes Mellitus;Coronary heart disease;cost;Data;Data Analyses;Development;diabetes management;Diabetes Mellitus;Disease;End stage renal failure;Environment;Ethnic Population;experience;Frequencies;Functional disorder;gene discovery;gene environment interaction;Genes;Genetic;genetic analysis;genetic association;Genetic Predisposition to Disease;Genetic Risk;Genome;genome-wide;genomic locus;Genomics;glycemic control;Goals;Health;Health Services Accessibility;Healthcare;Heritability;Heterogeneity;Hyperglycemia;improved;Individual;Inherited;insight;Kidney Diseases;Knowledge;macrovascular disease;Mediation;Microvascular Dysfunction;Minority Groups;Neuropathy;new therapeutic target;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Organ;Pathway interactions;Patient Selection;Patients;Peripheral Vascular Diseases;Phenotype;pleiotropism;Population;precision medicine;Predisposition;Prevention;Prevention strategy;Prevention therapy;Productivity;racial population;rare variant;Recommendation;Retinal Diseases;Risk;Risk Factors;Risk Management;risk sharing;risk stratification;risk variant;Role;Sample Size;sex;Smoking;Smoking Status;Stroke;Testing;Variant;Work

PROJECT_TITLE: Genomic, gene-environment and casual inference studies in diabetic complications

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Clinical Research;Contraception/Reproduction;Health Services;Hypertension;Lupus;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Systemic lupus erythematosus has been linked to excess preeclampsia in pregnancy and  preterm delivery, however promising preliminary data suggest that hydroxychloroquine may  protect pregnant women with lupus from these potentially catastrophic outcomes. This work  leverages three large population-based databases from around the world (United States, Israel,  and Sweden) with detailed prescription and clinical data to address threats to internal validity  common in pharmacoepidemiological studies such as confounding by indication and selection  bias while disentangling these outcomes from the effects of potential mediators such as  glucocorticoids and gestational diabetes. Finally, given that hydroxychloroquine is safe and  effective in pregnant women with lupus for managing their disease, we will work with patients  and providers to understand why pregnant women with lupus are either choosing not to use  this medication or are not being prescribed it in the first place.

PI_NAMEs: SIMARD, JULIA F (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Address;Adherence;adverse outcome;adverse pregnancy outcome;Affect;Ambulatory Care;Antiphospholipid Antibodies;Award;Behavioral Sciences;Benefits and Risks;Blindness;California;Cerebral Palsy;Child;chronic autoimmune disease;Clinical;clinical care;Clinical Data;Clinical Trials;cohort;comparative effectiveness study;Complication;cytokine;Data;Databases;design;Diagnosis;Discipline of obstetrics;Disease;Disease Management;Documentation;Early identification;early onset;effective therapy;Electronics;Epidemiologist;Epidemiology;experience;Female of child bearing age;Focus Groups;Funding;Future;General Population;Gestational Diabetes;Glucocorticoids;Goals;Guideline Adherence;health care availability;health care service organization;Heterogeneity;high risk population;Hydroxychloroquine;Hypertension;improved;Infant;Infection;Inflammatory;innovation;inpatient service;International;Interruption;Intervention;Israel;lens;Link;Lupus;Maternal Mortality;Mediating;Mediation;Mediator;Medical;medical schools;Mentored Research Scientist Development Award;Methodology;Methods;Modification;multidisciplinary;novel;Outcome;Oxidative Stress;parity;Pathogenesis;Patient Compliance;patient engagement;Patients;Pharmaceutical Preparations;Pharmacoepidemiology;Phenotype;phenotyping algorithm;Phospholipids;Placentation;Population;population based;Population Study;Pre-Eclampsia;Pregnancy;pregnant;Pregnant Women;premature;Premature Birth;Premature Infant;prevent;Primary Care;Production;programs;Proteinuria;Provider;provider adherence;Recommendation;recruit;reproductive;Research;Research Personnel;Residual state;Rheumatology;Risk;Risk Reduction;Selection Bias;Serology;Stroke;Sweden;Systemic Lupus Erythematosus;Toll-like receptors;United States;Universities;Woman;Work;working group;Writing

PROJECT_TITLE: Can hydroxychloroquine prevent preeclampsia and preterm delivery in lupus pregnancy?

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative: We propose to study the mitochondrial and molecular mechanisms occurring in cocaine action. We will examine adaptations in key brain reward neuronal cells in cocaine self-administration and how such adaptations influence reward circuits and drug seeking behavior. Our studies will provide new information into mitochondrial and molecular mechanisms in neuronal cell types in key reward brain regions in cocaine action.

PI_NAMEs: LOBO, MARY KAY  (contact)

PROJECT_TERMS: Affect;Amygdaloid structure;Behavior;behavioral response;Binding;Brain;brain reward regions;Cell Nucleus;cell type;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;Cocaine;cocaine exposure;cocaine seeking;cocaine self-administration;Dendrites;Dependovirus;Disease;Dopamine;Dopamine Receptor;Drug abuse;drug of abuse;drug seeking behavior;Dynamin I;epigenome;Exposure to;Foundations;Gene Expression;Genetic;genetic approach;Genetic Transcription;Globus Pallidus;Growth;high throughput analysis;Hippocampus;Intake;Intravenous;Label;lipidomics;Medial;Mediating;Mediator;metabolomics;Mitochondria;Modeling;Molecular;Monitor;Motivation;multiple omics;Mus;nano-string;neuronal circuitry;Neuronal Plasticity;Neurons;Nuclear;Nucleus Accumbens;Optics;Output;Pharmaceutical Preparations;Prefrontal Cortex;prevent;Process;Proteins;Proteomics;Rattus;Recurrent disease;Regulation;response;reward circuitry;Rewards;Ribosomes;RiboTag;Role;Self Administration;sensor;stimulant exposure;Substance Use Disorder;Synapses;tool;transcription factor;Transcription Process;transcriptome;transcriptomics;Ventral Tegmental Area;Viral;Work

PROJECT_TITLE: Cocaine-induced mitochondrial mechanisms and molecular mediators in reward circuitry

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Pregnancy;Prevention;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE The proposed research directly responds to calls from researchers, public health officials, and women’s health advocates for new measures that better capture what individuals wanted for themselves before and after a pregnancy became a part of their lives. By producing a novel measure of post-conception pregnancy acceptability, we will expand our understanding of the links between the contexts in which pregnancy occurs and reproductive health outcomes. Ultimately, measures of pregnancy acceptability can be incorporated into epidemiologic surveillance of the US’s ability to meet its citizens’ reproductive needs in ways that intentionally center individuals’ lived experiences and inform development of more effective, evidence-based and person- centered interventions to improve reproductive health outcomes and equity.

PI_NAMEs: BORRERO, SONYA B. (contact);SWITZER, GALEN E.

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: abortion;adverse outcome;Advocate;Affect;Affective;Age;Automobile Driving;Benchmarking;child bearing;Cognitive;cognitive interview;Communities;Complex;Conceptions;Conscious;Consensus;Contraception Behavior;Contraceptive methods;Development;Dimensions;driving force;Elements;Emotional;Epidemiologic Monitoring;Epidemiology;Equity;Evaluation;evidence base;experience;Family Planning Programs;Feedback;Fertility;Goals;Health;Health behavior and outcomes;health organization;Improve Access;improved;Individual;Intention;Intervention;Interview;Judgment;Life;Link;Lived experience;Longitudinal cohort;marginalized population;Measurement;Measures;Mediating;Methods;Modeling;neglect;novel;Outcome;person centered;Persons;Planned Pregnancy;Policies;Population;Pregnancy;Pregnancy Outcome;Premature Birth;Prenatal care;programs;Property;Psychometrics;Public Health;Qualitative Research;Rationalization;Reporting;reproductive;Reproductive Health;reproductive outcome;Research;Research Personnel;response;Review Literature;social;Social outcome;Social support;sound;statistics;Structure;substance use;Testing;trend;unintended pregnancy;Validation;Validity and Reliability;Woman;Women's cohort;Women's Health;women's reproductive health;Work

PROJECT_TITLE: Development and validation of a novel, person-centered measure of post-conception pregnancy acceptability


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Human Fetal Tissue;Human Genome;Maternal Health;Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

PI_NAMEs: BLELLOCH, ROBERT  (contact)

PROJECT_TERMS: Anatomy;Arteries;Biological Assay;Blood;Blood flow;candidate identification;Cells;Chorion;Chorionic Sac;Chorionic villi;Conditioned Culture Media;cytotrophoblast;Data;Decidua;Decidua Basalis;Defect;Development;Disease;Dissection;early pregnancy;early pregnancy loss;Embryo;endometriosis;Epigenetic Process;Epithelium;experimental study;Fertility;fetal;Fetal Growth Retardation;Fetal Membranes;Functional disorder;Generations;Genetic Transcription;Goals;Human;Immune;Immunologics;implantation;Inflammatory;insight;interest;Invaded;Investigation;Learning;Ligands;Location;Maps;migration;Modeling;Molecular;Morphology;novel;Obesity;Organoids;Pathway interactions;Placenta;placental membrane;Polycystic Ovary Syndrome;Population;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy Outcome;Premature Labor;Process;progenitor;programs;Property;protein profiling;Publishing;receptor;Repression;Risk;Second Pregnancy Trimester;Signal Transduction;single-cell RNA sequencing;Site;Source;stem cell differentiation;stem cell fate;stem cells;Stratified Epithelium;success;Surface;Surveys;Syncytiotrophoblast;Testing;theories;transcriptome;transcriptome sequencing;transcriptomics;trophoblast;trophoblast stem cell;Uteroplacental Circulation;Uterus;Villous;Villus;Work

PROJECT_TITLE: Establishing the development basis for the morphological and functional asymmetry of the human chorion


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Despite the availability of effective mental health treatment, approximately 47% of Latinx adults with serious mental illness are not engaged in treatment. The main goal of this current study is to identify cultural and social factors contributing to mental health treatment hesitancy and engagement; culturally adapt a Motivational Interviewing treatment engagement intervention that is trauma informed and peer delivered for Latinx with SMI; and conduct a pilot study to evaluate the feasibility, acceptability, and engagement of target mechanisms associated with the culturally adapted intervention. The proposed project will provide the groundwork for an R01 to test the effectiveness of the intervention.

PI_NAMEs: ROJAS PEREZ, OSCAR FERNANDO (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Address;Adult;Age;Alcohol consumption;Attention;Attitude;barrier to care;behavior change;behavior prediction;bilingualism;care delivery;career development;Caring;Chronic Disease;Clinical;Communities;Contraceptive Agents;cultural values;culturally appropriate intervention;design;Disinfection;Effectiveness;Effectiveness of Interventions;effectiveness testing;empowerment;Environment;Ethnic Origin;Ethnic Population;evidence base;experience;Foundations;Future;General Population;Glean;Goals;health inequalities;Health Personnel;Health system;implementation fidelity;implementation intervention;improved;Individual;Insurance;Intervention;Interview;K-Series Research Career Programs;Latinx;lens;Link;Lived experience;Los Angeles;maltreatment;Measles Vaccine;Mediating;Medicaid;medical specialties;medication compliance;Mental disorders;Mental Health;Mentors;Methods;Mexican;Mexico;Mood Disorders;Morbidity - disease rate;motivational enhancement therapy;National Institute of Mental Health;Neighborhoods;Outcome;peer;person centered;Persons;phenomenological models;physical conditioning;Pilot Projects;Population;Positioning Attribute;Premature Mortality;Prevention;programs;Provider;psychotic;Public Health;Quality of life;Race;racial population;Recovery;Research;Research Personnel;Research Support;satisfaction;Self-Injurious Behavior;service delivery;service engagement;Services;severe mental illness;Severity of illness;social;social factors;Strategic Planning;Suicide;Suicide attempt;Thinking;Training;Trauma;treatment adherence;treatment center;Treatment Efficacy;treatment response;Universities

PROJECT_TITLE: Abriendo Caminos: Engaging Latinx Communities Through Culturally Responsive Peer Delivered Motivational Interviewing

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


PI_NAMEs: GIUDICE, LINDA C (contact)

PROJECT_TERMS: Acceleration;Affect;Area;Artificial Intelligence;black women;bridge program;career;career development;Child;Clinical;clinical translation;Collaborations;Communication;Communities;community engagement;Community Health Education;community involvement;Community Networks;Community Outreach;Degree program;Development;Disadvantaged;Disadvantaged minority;disadvantaged student;Discipline of obstetrics;Disease;Doctor of Medicine;Doctor of Philosophy;early pregnancy;Education;Education and Outreach;Educational process of instructing;Educational Status;educationally disadvantaged;endometriosis;Ensure;Epigenetic Process;Equity;equity, diversity, and inclusion;Event;experience;Faculty;faculty mentor;Family;Fertility;Fertility Study;Festival;Future;girls;Goals;graduate student;Gynecology;Health;high school;high school program;High School Student;Immunologics;Infertility;infertility treatment;Inflammatory;Infrastructure;innovation;International;Internships;Knowledge;Laboratories;Learning;literacy;Master of Science;medical schools;Medicine;meetings;member;Mentors;minority student;minority undergraduate;Mission;Nursing Faculty;outreach program;Parents;Patient Education;Patients;Physicians;Postbaccalaureate;Postdoctoral Fellow;Pregnancy;Pregnancy Outcome;Professional Organizations;programs;Regenerative Medicine;Reproduction;reproductive;Reproductive Biology;Reproductive Health;Reproductive Sciences;Research;Research Personnel;Resources;San Francisco;Science;scientific literacy;Scientist;Series;social media;sociodemographics;stem cell biology;Stream;Structure;student mentoring;student training;Students;success;summer program;teacher;Training;training opportunity;Training Programs;undergraduate research;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;web site;webinar;Women's Health;Work

PROJECT_TITLE: Education - Outreach Core


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: Chicago

ORG_DEPT: BIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative The goal of this project is to elucidate the molecular and genetic mechanisms that control the expression of odorant receptors—which exhibit an unusual form of random monoallelic expression. The experiments will shed light on genetic mechanisms that play a central role in defining the vast array of cell types that make up the mammalian brain, and that influence development, phenotypic variation, and disease.

PI_NAMEs: BOZZA, THOMAS  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: 3-Dimensional;Afferent Neurons;Alleles;Amines;Biological Models;Biological Process;Brain;cell type;Chromatin;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;defined contribution;derepression;Development;Disease;DNA;Dorsal;Dosage Compensation (Genetics);Elements;Enhancers;Environment;Epigenetic Process;Excision;Exhibits;experimental study;Family;Gene Cluster;Gene Expression;Gene Family;Gene Order;Gene Targeting;Genes;Genetic;Genetic Enhancer Element;Genome;genome-wide;Goals;interest;Knowledge;Light;Mammals;Modeling;Molecular;Molecular Conformation;Mus;Mutation;Names;Neurobiology;Neuronal Differentiation;Neurons;novel;Nuclear;Odorant Receptors;Olfactory Epithelium;Olfactory Pathways;olfactory receptor;olfactory sensory neurons;Pathogenesis;Phenotype;Play;Population;prevent;Probability;promoter;Property;receptor;receptor expression;Receptor Gene;Role;Specific qualifier value;Specificity;Testing;Variant

PROJECT_TITLE: Mechanisms of Trace Amine-associated Receptor Gene Choice