ORG_CITY: LEEDS

ORG_NAME: NORTHAMPTON VA MEDICAL CENTER

ORG_STATE: MA

PHR: More than 30,000 veterans are hospitalized for stroke each year, and in the critical first months of recovery, at least half are disabled by abnormal 3-D spatial function (spatial neglect). Their self-care, mobility, and ability to return home are severely limited. Worse, many of these veterans are never diagnosed, counseled about the problem, or prescribed spatial rehabilitation. Here, we attempt to speed up spatial neglect diagnosis, using the brain imaging that is always part of the first hours of stroke care. We will compare 4 methods to identify the special brain imaging features present in people with spatial neglect who respond to early rehabilitation, and who recover best at 3 and 6 months after stroke. Once we complete this study, the next step will be to confirm our findings in a larger project, to ensure clinical brain imaging can be used for treatment assignment in veterans across gender, race, and other characteristics.

PI_NAMEs: BARRETT, A. M. (contact)

PROJECT_TERMS: 3-Dimensional;acute stroke;Address;Affect;American Heart Association;anatomic imaging;associated symptom;Atlases;Awareness;Behavioral;Biological;Biological Markers;biomarker validation;Brain;Brain imaging;brain magnetic resonance imaging;Cardiac;care costs;care delivery;Caregivers;Caring;Characteristics;Clinical;clinical biomarkers;clinical imaging;clinical predictors;Cognition Disorders;Cognitive deficits;cognitive disability;cognitive rehabilitation;Communities;comparative;connectome;Consumption;Counseling;Data;design;Diagnosis;Diffusion Magnetic Resonance Imaging;disabled;Elements;Ensure;experience;Failure;Family Caregiver;Freedom;frontal lobe;functional disability;functional gain;functional improvement;functional independence;functional outcomes;Gender;Goals;high resolution imaging;Home;Hospitalization;Hour;Image;imaging biomarker;Imaging Techniques;improved;improved outcome;Injury;Lead;Left;Lesion;Life;Magnetic Resonance Imaging;Maps;Measurable;Measures;Methods;Motor;motor deficit;Movement;neural correlate;Neuroanatomy;Neurocognitive;neuroimaging;Neuropsychology;novel;novel strategies;observational cohort study;Outcome;Pathologic;Patients;Perception;personalized biomarkers;personalized care;Persons;post stroke;potential biomarker;predicting response;Process;Protocols documentation;Quality of life;Race;Recommendation;Recovery;Recovery of Function;Rehabilitation Outcome;Rehabilitation therapy;rehabilitative care;Reporting;Research;Research Personnel;Resolution;response;Rest;screening;Self Care;Serum;Site;skills;social;spatial neglect;Speed;statistics;Stroke;stroke outcome;stroke rehabilitation;stroke survivor;Structure;Supervision;Technical Expertise;Testing;Time;Translating;treatment planning;treatment response;Troponin;Veterans;white matter;white matter damage;Work

PROJECT_TITLE: A biomarker for personalized care in post-stroke spatial neglect

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: NARRATIVE Fatty liver disease and chronic kidney disease, affecting tens of millions of people in the US alone, exhibit pathological dysregulation of lipid metabolism, which is heavily dependent on the pivotal cofactor coenzyme A (CoA). CoA is synthesized from the essential nutrient vitamin B5 and is absolutely required for lipid synthesis, fatty acid oxidation, and the TCA cycle among other critical pathways, but little attention has been paid to how CoA supplies are actively coordinated with metabolic and biosynthetic demands, including in kidney and liver. Completion of our aims in both mammalian and fly models will reveal new regulatory mechanisms (metabolite signals and signaling pathways) for CoA synthesis, advance our mechanistic understanding of the in vivo roles of CoA synthesis enzymes, establish novel tools and models, and provide foundational knowledge for potentially manipulating CoA synthesis as a new therapeutic strategy.

PI_NAMEs: DIBBLE, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Acetyl Coenzyme A;Acyl Coenzyme A;acyl group;Address;Affect;Anabolism;Animal Model;Animals;Attention;Carbon;Cells;Choristoma;Chronic Kidney Failure;Citric Acid Cycle;Coenzyme A;cofactor;Critical Pathways;Disease;Disease Progression;Drosophila genus;Energy Supply;enzyme biosynthesis;enzyme pathway;Enzymes;Enzymes and Coenzymes;Evolution;Exhibits;Family;Fasting;fatty acid oxidation;fatty liver disease;feeding;fly;Functional disorder;Genes;Genetic;Genetic Transcription;Goals;Homeostasis;Human;in vivo;innovation;insight;insulin signaling;Isotopes;Kidney;kidney metabolism;Knowledge;Link;lipid metabolism;lipidomics;Lipids;Liver;liver metabolism;Mass Spectrum Analysis;Mediating;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;metabolomics;Modeling;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Nutrient;Obesity;Orthologous Gene;Pantothenate kinase;Pantothenic Acid;Pathologic;Pathway interactions;Persons;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiology;PIK3CG gene;Play;Process;Protein Biochemistry;Proto-Oncogene Proteins c-akt;Proximal Kidney Tubules;Pump;Regulation;response;Risk Factors;Role;Signal Pathway;Signal Transduction;solute;Tissues;tool;Triglycerides;Vertebrates;vitamin biosynthesis;Vitamins

PROJECT_TITLE: Regulation and Requirements for Coenzyme A Biosynthesis

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Childhood Injury;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sleep Research;Social Determinants of Health;Sudden Infant Death Syndrome

PROJECT_TERMS: Academy;Accidents;Address;Agreement;Alaska Native;American;American Indians;Asian;Asphyxia;Award;Back to Sleep;Beds;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chronic Disease;Collaborations;Communication;Communities;Contractor;Contracts;Data;Death Rate;Development;disorder prevention;Educational Materials;Elderly;Electronic Mail;Ensure;Environment;ethnic difference;ethnic disparity;Ethnic Population;evidence base;Feedback;Funding;Guidelines;Health Promotion;Health Service Area;High Prevalence;Hispanic;improved outcome;Infant;Infant Mortality;Live Birth;Low Prevalence;Mothers;National Institute of Child Health and Human Development;Native Hawaiian or Other Pacific Islander;Not Hispanic or Latino;Outcome;outreach;Pediatrics;prevent;Process;programs;racial difference;racial disparity;racial population;Recommendation;Reproductive Health;Resources;Risk Reduction;Secure;Sleep;Sudden infant death syndrome;Surface;Surveys;Telephone;Training;tribal leader;U-Series Cooperative Agreements;United States;United States Indian Health Service;Update;working group

PROJECT_TITLE: Healthy Native Babies Project


NIH_SPENDING_CATS: Pediatric;Prevention

ORG_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PROJECT_TERMS: Address;Agreement;Centers for Disease Control and Prevention (U.S.);Child;Child Health;Collaborations;Collection;Communication;cost;Data;data dissemination;data integration;data quality;Databases;Development;Family;Fostering;Funding;improved;Measurement;meetings;National Institute of Child Health and Human Development;Periodicals;Personal Satisfaction;Policy Maker;Preparation;Printing;Production;Program Effectiveness;Public Policy;Publications;Reporting;Research;Research Personnel;statistics;United States National Center for Health Statistics;web site;Work

PROJECT_TITLE: SUPPORT FOR THE FEDERAL INTERAGENCY FORUM ON CHILD HEALTH AND FAMILY STATISTICS


ADMINISTERING_IC: DA

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: NARRATIVE The marmoset is an increasingly attractive non-human primate (NHP) model for understanding neurophysiology and there is a major interest in the field for using it to study neurodegenerative diseases, particularly to model the social and cognitive deficits that accompany them, which current animal models are unable to do. At present, no NHP models exist with trinucleotide repeat mutations at the endogenous allele as occurs in Huntington’s disease, in part because of limitations in the ability of the CRISPR/Cas9 system to introduce long stretches of DNA, as well as limitations in marmoset reproductive technologies. Therefore, we propose to establish a new strategy that utilizes the expanded developmental potential of ground-state pluripotent cells to generate animals that carry the precise human mutation through assistant reproductive technologies, which we believe will pave the road for transgenic marmoset models as superior preclinical models to transgenic mice.

PI_NAMEs: BRIVANLOU, ALI H (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Address;Affect;Alleles;Amino Acids;Animal Model;Animals;autosome;Behavior;Behavioral;behavioral phenotyping;behavioral response;Biology;Birth;blastocyst;Brain imaging;Breeding;Callithrix;Callithrix jacchus jacchus;Cell Line;Cells;Code;Cognitive deficits;cognitive process;Collaborations;Communities;Complex;Corpus striatum structure;CRISPR/Cas technology;Derivation procedure;Development;Developmental Biology;developmental disease;differentiation in vitro;differentiation protocol;Disease;disease model;Disease Progression;DNA;Embryo;embryonic stem cell;Exons;Experimental Genetics;Fertilization in Vitro;Frequencies;Functional disorder;Genes;Genome;Germ Cells;Germ Lines;Grant;Guide RNA;Heritability;homologous recombination;Human;Huntington Disease;Huntington gene;Imaging technology;In Vitro;insight;interest;Knock-in;Knock-out;knockout gene;Laboratories;Mental disorders;Modeling;Molecular;molecular phenotype;Monitor;Morula;Mus;mutant;Mutation;Nervous System;Nervous System Disorder;neural;neural circuit;Neurodegenerative Disorders;neurogenetics;Neuronal Differentiation;Neurons;neurophysiology;nonhuman primate;Onset of illness;optogenetics;Outcome;Performance;Peripheral;Phenotype;pluripotency;Pluripotent Stem Cells;polyglutamine neurodegenerative diseases;Population;post pregnancy;Pre-Clinical Model;prevent;Primate Diseases;Primates;Proteins;Protocols documentation;Reporter;Reporter Genes;Reproductive Technology;Research;Retrieval;Role;Serial Magnetic Resonance Imaging;single-cell RNA sequencing;Social Behavior;social deficits;stem cell biology;stem cells;Stretching;Surgical Replantation;System;Technology;transcriptomics;Transgenic Mice;Transgenic Organisms;transmission process;Trinucleotide Repeats;Universities;Visuospatial

PROJECT_TITLE: Correlating molecular behavioral phenotypes in a marmoset model of Huntingtons disease


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Natural Products;Opioid Misuse and Addiction;Opioids;Substance Misuse;Therapeutic Cannabinoid Research

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative The opioid crisis has highlighted the need for enhanced non-opioid pharmacological therapies for the treatment of opioid use disorder. The present research project will characterize the development of a patented technology with cannabidiol, a non-intoxicating compound, on pharmacokinetics, tolerability, drug craving and relapse in individuals with heroin use disorder.

PI_NAMEs: HURD, YASMIN L. (contact)

PROGRAM_OFFICER_NAME: SOUSA, JASON CARLOS

PROJECT_TERMS: absorption;Abstinence;Acute;addiction;Address;Adverse effects;Affect;Animals;Anxiety;Attention;Behavior;Biological Availability;Cannabidiol;Cannabinoids;Chronic;Clinical;clinical investigation;Clinical Research;Clinical Trials;clinically relevant;Communities;cost;craving;Cues;Development;Disease;Dose;Double-Blind Method;drug abstinence;drug craving;Drug Kinetics;drug relapse;Ecological momentary assessment;effective therapy;Environment;Epidemic;FDA approved;follow-up;Foundations;gastrointestinal;Heroin;heroin use;Hour;Illicit Drugs;improved;Incidence;Incubated;Individual;insight;instrument;Kinetics;Knowledge;Legal patent;long chain fatty acid;Long-Term Effects;Longitudinal Studies;Measures;Medical;medication-assisted treatment;Metabolism;Methadone;Monitor;Neurobiology;non-opioid analgesic;novel;novel therapeutics;Opioid;Opioid agonist;opioid agonist therapy;opioid epidemic;opioid misuse;opioid use disorder;opioid withdrawal;Oral;Outcome;Outcome Measure;outpatient programs;overdose death;Participant;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Phase;Physiological;placebo controlled study;Placebos;Plasma;Population;pre-clinical;prescription opioid;Process;psychosocial;Randomized;Rattus;Recurrent disease;Regimen;Relapse;relapse prevention;Research;Research Project Grants;Risk;Safety;Services;side effect;Social Functioning;social stigma;System;Technology;Technology Assessment;Therapeutic;Therapeutic Intervention;Time;tool;Toxicology;Treatment Failure;treatment strategy;Urine;Woman

PROJECT_TITLE: Cannabidiol in the treatment of opioid use disorder


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The overarching goal of this proposed research is to identify novel pathways to prevent or slow Alzheimer's Disease and related dementias (ADRD) by investigating the primary drivers of cognitive resilience. We aim to generate a detailed biological framework for understanding how an individual's underlying genetic architecture and environmental factors combine to produce cognitive resilience in older adults. These results will be critical for designing future public health strategies and clinical interventions to reduce the burden of ADRD by fostering cognitive resilience in aging populations.

PI_NAMEs: THOMAS, ALVIN G. (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Animals;Atherosclerosis Risk in Communities;Award;Biological;Biological Markers;biracial;Brain Pathology;brain volume;Cardiovascular Diseases;career;Clinical;clinical trial enrollment;Cognitive;cognitive function;cognitive reserve;cohort;Communities;Complex;Data;Dedications;design;Diabetes Mellitus;Disease;doctoral student;early childhood;Economic Burden;Education;effective therapy;Elderly;Environment;Environmental Risk Factor;Epidemiology;epidemiology study;follow-up;Fostering;Future;General Population;Genes;Genetic;genetic architecture;genome wide association study;genomic data;Genomics;Goals;Health;Heritability;Heterogeneity;Human;Image;Impaired cognition;Individual;innovation;insight;Intervention;Joints;Lead;Magnetic Resonance Imaging;Maps;Measurement;Measures;men;Mendelian randomization;Mentors;Methods;Modality;Modeling;Molecular;multiple omics;neuroimaging;neuropathology;nonalzheimer dementia;novel;older adult;Pathway interactions;Phase;Phenotype;Physical activity;Plasma;Plasma Proteins;polygenic risk score;Population;Population Study;Postdoctoral Fellow;pre-doctoral;prevent;Prevention;Prevention strategy;Proteins;Proteome;Psychometrics;Public Health;Qualifying;Quantitative Trait Loci;Research;Research Personnel;Research Project Grants;resilience;resilience in aging;risk stratification;Sample Size;Scientist;social;Socioeconomic Status;Source;Training;trait;treatment strategy;Visit;Women's cohort;Work

PROJECT_TITLE: Genetic and Environmental Drivers of Cognitive Resilience in Aging Populations


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hearing Loss;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE The U.S. Deaf community – a group of more than 500,000 Americans who communicate using American Sign Language (ASL) – experiences nearly triple the rate of lifetime problem drinking and twice the rate of trauma exposure compared to the general population. Although there are several treatments for alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) in hearing populations, none have been developed for or tested with Deaf clients. To address these barriers, our team developed Signs of Safety, a Deaf-accessible therapy toolkit for treating AUD and PTSD. We propose a nationwide, virtual clinical trial to compare (1) Signs of Safety with (2) treatment as usual and (3) a no treatment control, to collect data on clinical outcomes, and to explore potential mediators and moderators of outcome.

PI_NAMEs: ANDERSON, MELISSA LEE (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Acceleration;addiction;Address;Adult;Aftercare;Alcohol abuse;alcohol abuse therapy;alcohol comorbidity;Alcohol consumption;alcohol use disorder;Alcohols;American;American Sign Language;arm;artist;Back;behavioral health;Client;Clinical;Clinical Trials;Cognitive;Cognitive Therapy;Collaborations;Communication;Communities;community engagement;coping;Coping Skills;Counseling;COVID-19 pandemic;Data;deaf;Development;Disparity;DSM-V;Education;Educational process of instructing;emotional abuse;Employment;Enrollment;evidence base;Evidence based treatment;experience;falls;Feasibility Studies;feasibility testing;Film;follow-up;Foundations;fourth grade;Frequencies;functional outcomes;Future;General Population;Health;Hearing;Immigrant;Impairment;indexing;Individual;Infrastructure;Intervention;Language;literacy;Literature;Manuals;Mediator;Mental Health;Mental Health Services;Methods;Motivation;Outcome;Participant;Persons;physical abuse;physical conditioning;pilot test;Population;Post-Traumatic Stress Disorders;Problem Solving;programs;Protocols documentation;Provider;psychoeducation;Psychotherapy;Randomized;recruit;Reporting;Research;Research Personnel;Resources;response;Safety;Self Efficacy;self-compassion;Services;Severities;Sexual abuse;Sign Language;Socialization;Testing;Text;timeline;Translations;Trauma;trauma exposure;treatment as usual;Treatment Protocols;treatment research;trial comparing;verbal;virtual;virtual clinical trial;virtual platform;Visual;Vocabulary;Waiting Lists;Work;Writing

PROJECT_TITLE: Evaluating Signs of Safety: A Deaf-Accessible Therapy Toolkit for AUD and Trauma

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: ROCHESTER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Splicing of gene transcripts is an essential process in human cells and frequently dysregulated in disease. Despite progress, the molecular-level mechanisms of splice site identification are incompletely understood. We seek to understand how the splicing machinery identifies gene transcripts for processing into legible RNA messages, thereby providing context for personalized medicines to treat patients with dysfunctional splicing.

PI_NAMEs: KIELKOPF, CLARA  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 3' Splice Site;Address;Binding;Biological Assay;biophysical techniques;Calorimetry;cancer recurrence;Cells;Co-Immunoprecipitations;Cryoelectron Microscopy;Dinucleoside Phosphates;Disease;Dissociation;Ensure;Fluorescence;Fluorescence Resonance Energy Transfer;Genes;Goals;Human;human disease;Malignant Neoplasms;Molecular;Molecular Conformation;molecular recognition;mRNA Precursor;Mutation;Neurodevelopmental Disorder;Nucleotides;Patients;personalized medicine;Phosphorylation;Process;Protein Dephosphorylation;Recurrence;response;RNA;RNA Binding;RNA Splicing;SF1;Signal Transduction;single molecule;Site;Spliced Genes;Spliceosomes;Transcript;transcriptome;U2 Small Nuclear Ribonucleoprotein;X-Ray Crystallography

PROJECT_TITLE: Molecular Recognition During Pre-mRNA Splicing


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE Understanding how cells in the embryo interpret complex signals to create organs is one of the most challenging and important questions in biology. We propose to develop in vitro models of organ development by combining human stem cells, advanced tissue engineering, and genomic editing techniques that will allow us to study de- tailed molecular mechanisms of organ formation in the human gut, from the lungs to the large intestine. The proposed work will significantly advance the current paradigms in stem cell biology and will innovate technol- ogies of recreating precise human organ tissues in a lab, and eventually enable high-throughput drug screening, and physiological modeling of gut homeostasis, chronic inflammation, and infections.

PI_NAMEs: SIMUNOVIC, MIJO  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: 3-Dimensional;Biochemical;Biology;Bypass;Cells;Characteristics;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Colon;Complex;Coupling;Developmental Biology;Embryo;embryonic stem cell;Embryonic Structures;fetal;Fetal Development;Gene Expression Profile;Genetic;genome editing;Germ Layers;gut homeostasis;high-throughput drug screening;Human;human pluripotent stem cell;human stem cells;human tissue;In Vitro;in vitro Model;Infection;Inflammation;Knowledge;Large Intestine;live cell microscopy;Lung;mechanical signal;Microfluidics;Molecular;Morphogenesis;morphogens;novel;Organ;organ growth;Organogenesis;Organoids;Pathway interactions;Patients;Pattern;physiologic model;pluripotency;Process;Protocols documentation;reconstitution;Regenerative Medicine;Reproducibility;Route;self organization;Signal Pathway;Signal Transduction;Source;spatiotemporal;stem cell biology;System;Techniques;technological innovation;Thymus Gland;Time;Tissue Engineering;Tissues;tool;Transcriptional Regulation;transcriptomics;Tube;Work

PROJECT_TITLE: Synthetic organogenesis: new paradigms in reconstituting human organ development in vitro


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Macular Degeneration;Nanotechnology;Neurodegenerative

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This project optimizes a new, safe imaging technology using a combination of light and sound in large animal eye models of wet macular degeneration. Imaging characteristics predicting lack of response to treatment are determined, and new nanoparticles for enhancement of imaging which are able to be safely excreted in the urine are evaluated. The long term goal of this project is to develop a multimodal molecular imaging using gold nanoparticles to image biomarkers predicting response to treatment to develop novel therapies of eye diseases.

PI_NAMEs: PAULUS, YANNIS MANTAS (contact);WANG, XUEDING

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Age related macular degeneration;Aging;Animal Model;Animals;bevacizumab;Biological Markers;Biology;biomaterial compatibility;Blindness;Blood capillaries;Blood Vessels;Characteristics;Choroidal Neovascularization;Clinical assessments;clinically relevant;Contrast Media;Development;Discipline;Disease;Ensure;Excretory function;Exhibits;Eye;Eye diseases;Fluorescence Microscopy;Functional Imaging;Goals;Histology;Image;Image Enhancement;imaging biomarker;imaging modality;imaging platform;imaging system;Imaging technology;Immunohistochemistry;improved;in vivo;Integrin alphaVbeta3;Integrins;invention;Legal Blindness;legally blind;Light;Macular degeneration;matrigel;Methods;microscopic imaging;Microscopy;Modeling;Molecular;molecular imaging;molecular marker;Molecular Target;Monitor;Morphologic artifacts;Motion;Multimodal Imaging;multimodality;nanoGold;nanoparticle;non-invasive imaging;novel;novel therapeutics;Optical Coherence Tomography;Oryctolagus cuniculus;Pathologic;Patients;Peptides;Performance;Pharmacologic Substance;Population;pre-clinical;predicting response;prognostication;ranibizumab;real-time images;Real-Time Systems;Renal clearance function;Research;research and development;Resolution;response;Safety;Scanning;serial imaging;sound;Speed;subretinal injection;System;technology development;technology platform;temporal measurement;Testing;Time;tool;Toxic effect;translational impact;treatment response;United States;Urine;Vascular Endothelial Growth Factors;Visualization;Work

PROJECT_TITLE: Multimodal Molecular Imaging of Choroidal Neovascularization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Prevention

ORG_CITY: Newark

ORG_DEPT: SURGERY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: RUTGERS CANCER INSTITUTE OF NEW JERSEY PUBLIC HEALTH RELEVANCE STATEMENT The catchment area of Rutgers Cancer Institute of New Jersey (CINJ) is the state of New Jersey (NJ), with a diverse population of over 9.2 million. In 2019, NJ ranked 6th in cancer incidence rates nationwide with 483.7 cases per 100,000 (54,271 cases). CINJ is the State of New Jersey's only National Cancer Institute (NCI)- designated Comprehensive Cancer Center. The mission of CINJ is to reduce the burden of cancer by advancing cancer research, prevention, screening and education for the most densely-populated and one of the most ethnically and socioeconomically diverse states in the US.

PI_NAMEs: LIBUTTI, STEVEN K. (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;Advocacy;Agreement;anti-cancer research;Appointment;Award;Basic Science;biobank;biomedical informatics;Biometry;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;cancer genetics;Cancer health equity;Cancer Hospital;Cancer Institute of New Jersey;Cancer Patient;cancer pharmacology;cancer prevention;cancer risk;Cancer Survivor;cancer therapy;career;Catchment Area;Clinical;clinical investigation;Clinical Research;Clinical Trials;Collaborations;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;County;Data;Education;Equity;equity, diversity, and inclusion;Ethnic Origin;Evaluation;evidence base;Evidence based intervention;Evolution;Faculty;Faculty Recruitment;Family member;Flow Cytometry;Funding;Future;Future Teacher;genome editing;Genomic Instability;Genomics;graduate student;Grant;Growth;health care quality;Health Sciences;Health system;Histopathology;Home;Hospitals;Human;Immunologic Monitoring;improved;Incidence;Individual;innovation;Institution;interdisciplinary collaboration;Intervention;investigator-initiated trial;Investments;Joints;Leadership;leadership development;Malignant Childhood Neoplasm;Malignant Neoplasms;member;metabolomics;Minority Groups;Mission;Modeling;multidisciplinary;National Cancer Institute;New Jersey;novel;Nurses;oncology service;Outcome;outreach;Pathogenesis;Patient Care;patient screening;Patients;Peer Review;Physicians;Policies;Population;Population Heterogeneity;Postdoctoral Fellow;Precision therapeutics;Prevention;Program Development;programs;public health relevance;Public Policy;Quality of life;Research;Research Activity;Research Infrastructure;Research Institute;Research Personnel;Resource Sharing;Resources;Risk;Role;Science;screening;Screening for cancer;Services;Site;socioeconomics;Strategic Planning;Structure;success;System;Therapeutic Intervention;Therapeutic Trials;Training;Training and Education;Translating;tumor immunology;tumor metabolism;undergraduate student;Underrepresented Minority;Underrepresented Populations;Universities;Vision;Visit;Work

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Hearing Loss;Nanotechnology;Neurosciences;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PITTSBURGH

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: RELEVANCE TO PUBLIC HEALTH The proposed research is relevant to public health because it addresses the delivery problem to treat or possibly prevent hearing loss. The proposal describes an ex vivo platform for testing transport and uptake of therapeutics into the inner ear and explores the potential of nanovesicles specially exosomes to enhance intratympanic transport of therapeutics that are currently considered for clinical trials or are in the clinical trial (neurotrophins for regeneration of neurons and AAVs (gene therapy) and small molecules (Chir and VPA) for regeneration of hair cells) in vitro and in vivo. Since the success of this research would open a new delivery horizon to advance regeneration and pharmacotherapeutics to treat and prevent hearing loss, the work is relevant to the part of the NIH’s mission that pertains to reducing illness and disability.

PI_NAMEs: MOATTI, ADELE  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Address;Affect;Amino Acid Sequence;Animal Model;Animals;Biological Models;Cell membrane;Cell Membrane Permeability;Cell secretion;Cells;Clinical Treatment;Clinical Trials;Cochlea;Data;deafness;Diffuse;disability;Drug Screening;Ear;efficacy testing;Encapsulated;Excision;exosome;extracellular;extracellular vesicles;Family suidae;FDA approved;gene therapy;Genes;Genetic;Goals;hair cell regeneration;Hearing;hearing impairment;hearing loss treatment;Human;human tissue;improved;In Vitro;in vivo;Individual;Injections;Labyrinth;Liposomes;Measures;Membrane;membrane model;Mesenchymal Stem Cells;Methods;Mission;Modeling;nanocarrier;nanovesicle;Natural regeneration;neuron regeneration;neurotrophic factor;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Pathology;Patients;Perilymph;Permeability;Pharmaceutical Preparations;Phase;Physiology;porcine model;pre-clinical;prevent hearing loss;Procedures;Proteins;Public Health;regenerative therapy;Reporting;Research;Research Personnel;Risk;Rodent;round window;Sampling;small molecule;stem cell exosomes;success;System;Testing;Therapeutic;Thick;Time;tool;Translating;Trauma;Tympanic membrane;United States National Institutes of Health;uptake;vesicle transport;Work

PROJECT_TITLE: Enhanced intratympanic delivery of therapeutics to treat and prevent hearing loss using nanovesicles in the porcine model

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: Durham

ORG_NAME: XILIS, INC.

ORG_STATE: NC

PHR: PROJECT NARRATIVE There remains a need to adopt cross-functional strategies to reduce the high costs and long lead times for developing novel models for functional precision medicine. As a solution, Xilis is leveraging its multi-disciplinary team to advance the commercial development of our benchtop microfluidic instrument that can rapidly generate and scale micro-organospheres (MOS) – high-fidelity, ex vivo patient avatars, which can predict patient response to treatments. Successful completion of this project will lead to a commercial-grade, automated instrument that can be readily plugged into the clinical workflow to expedite various downstream applications including diagnostic assay and drug development efforts.

PI_NAMEs: NELSON, DANIEL AARON (contact)

PROGRAM_OFFICER_NAME: LI, MELISSA WANLING

PROJECT_TERMS: Adopted;Architecture;Area;assay development;Biological;Biopsy;Cancer Biology;Cancer Center;cancer clinical trial;Cancer Diagnostics;cancer therapy;Cells;Chemoresistance;Clinic;Clinical;clinical care;Clinical Research;Clinical Trials;clinically actionable;Collaborations;Colorectal Cancer;Commercial grade;Complex;Computer software;cost;design;Development;Devices;diagnostic assay;diagnostic development;Disease;Disinfection;Disparate;drug development;Drug Screening;Electronics;Emulsions;Endocrine;Engineering;Environmental Risk Factor;Excision;experience;Funding;Generations;Genetic;Goals;Growth;Heart;improved;Institutional Review Boards;instrument;Lead;Malignant Breast Neoplasm;Malignant Neoplasms;Manuals;matrigel;Measures;Medical Device;Membrane;metastatic colorectal;Microfluidic Microchips;Microfluidics;minimal risk;Modality;Modeling;Monitor;multidisciplinary;Multiple Myeloma;novel;Oils;operation;Organoids;Outcome;patient response;Patients;personalized medicine;Phase;polymerization;Polymers;Population Heterogeneity;precision medicine;precision oncology;Procedures;Process;prototype;Publishing;Pump;Recovery;Reporting;Reproducibility;Resistance;Sampling;Series;Site;Small Business Innovation Research Grant;Standardization;stem cells;success;System;Testing;Therapeutic;treatment response;Tube;Universities;Validation;Xenograft procedure

PROJECT_TITLE: An integrated microfluidic device for patient-derived micro-organospheres


NIH_SPENDING_CATS: Behavioral and Social Science;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative  Vestibular dysfunction is a significant public health problem with evidence of postural instability has been reported in 35% of older adults, yet the effects of noise, on central vestibular pathways and resulting behavioral dysfunction are understudied. The proposed studies will expand our knowledge of afferent irregular fiber contributions to activation of vestibular nuclei, by assessing neuronal activity, indicators of synaptic transmission, and behavioral performance following bilateral noise-induced hypofunction. In the future, these results will contribute to the development of targets and a temporal window for pharmacotherapeutic intervention to direct vestibular rehabilitation.

PI_NAMEs: HOLT, AVRIL GENENE  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Address;Adult;Affect;Age;Animals;Behavior;behavior change;Behavioral;Bilateral;Biological Markers;bone;Brain;Calcium;calretinin;Cause of Death;Cerebellum;Cervical;Cessation of life;Characteristics;Clinic;Complex;Craniocerebral Trauma;Detection;Development;Dissociation;Dizziness;Dose;Environment;Evoked Potentials;Exhibits;fall risk;falls;Fiber;FOS gene;Frequencies;Functional disorder;Future;Glutamates;Head Movements;hearing impairment;Hearing Tests;Human Resources;Impaired cognition;in vivo;in vivo imaging;inhibitory neuron;Injury;Intervention;Interview;Knowledge;Label;Labyrinth;Link;Loudness;Magnetic Resonance Imaging;Manganese;Measurement;Modeling;Molecular;Molecular Genetics;molecular marker;Morphology;Motor;mouse model;Movement;Musculoskeletal Equilibrium;Neurodegenerative Disorders;Neurons;Noise;noise exposure;notch protein;Nuclear;older adult;Organ;otoconia;Pathway interactions;Pattern;Perception;Performance;Peripheral;Persons;Population;posture instability;premature;prevent;Public Health;Recording of previous events;Recovery;Reflex action;Rehabilitation therapy;Reporting;response;Risk;Role;skills;Symptoms;Synapses;synaptic function;Synaptic Transmission;System;Task Performances;Testing;Time;Vertigo;Vestibular dysfunction;Vestibular function;Vestibular Nerve;Vestibular nucleus structure;vestibular pathway;vestibular system;Walking

PROJECT_TITLE: The impact of peripheral injury on central vestibular pathways


NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD)

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Centrosomes are required for error-free mitosis and other cellular functions, and their deregulation drives developmental disorders, such as microcephaly and cancer. This proposal investigates novel paradigms of centrosome regulation by examining the functional consequences of mRNA localized to centrosomes.

PI_NAMEs: LERIT, DOROTHY A (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Active Biological Transport;Acute;Adhesions;autism spectrum disorder;Biochemistry;Biology;brain size;cancer biomarkers;cell behavior;Cell Cycle;Cell division;Cell Physiology;Cell Survival;cell type;Cells;Cellular biology;Centrosome;Chromosomal Instability;cilium biogenesis;Complex;Congenital Abnormality;Coupled;Data;Developmental Delay Disorders;developmental disease;Disease;disease model;Drosophila genus;Dynein ATPase;Embryo;Engineering;fly;FMR1 gene;Foundations;Functional disorder;Future;Genetic;Genome Stability;Goals;Head;Health;Heritability;Homeostasis;Human;Image;Intellectual functioning disability;interdisciplinary approach;Interphase;Knowledge;Learning;Link;Malignant Neoplasms;Memory;Messenger RNA;Microcephaly;Microtubule-Organizing Center;Microtubules;migration;Minus End of the Microtubule;Mitosis;Mitotic spindle;Modeling;Monitor;Motor;Mutation;Neurodevelopmental Disorder;Normal Cell;novel;Paraneoplastic Cerebellar Degeneration;pericentrin;posttranscriptional;Prognostic Marker;Proliferating;Protein Biosynthesis;Proteins;recruit;Regulation;response;Ribonucleoproteins;RNA;RNA Sequences;RNA-Binding Proteins;Role;Site;spatiotemporal;Structure;Testing;trafficking;Translations;Work

PROJECT_TITLE: Post-transcriptional mechanisms of centrosome regulation


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases

PI_NAMEs: POSNER, MARSHALL R (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Aging;aging biomarker;AIDS related cancer;Area;Award;Back;bench to bedside;cancer care;cancer cell;cancer clinical trial;Cancer Patient;cancer risk;cancer therapy;Clinic;clinical development;clinical investigation;clinical translation;Clinical Trials Design;Collaborations;Direct Costs;Discipline;Doctor of Philosophy;Education;Fostering;Funding;Goals;Immune system;Immunooncology;improved;innovation;Laboratories;Malignant Neoplasms;medical schools;meetings;member;Mission;novel therapeutic intervention;Paper;Patients;Peer Review;Persons;Population;preclinical development;Process;programs;Publishing;Research;Science;Therapeutic;Therapeutic Trials;therapy development;Translating;treatment strategy;tumor microenvironment;Work;working group

PROJECT_TITLE: Cancer Clinical Investigation


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: SANTA MONICA

ORG_NAME: SYMPHONY BIOSCIENCES, INC.

ORG_STATE: CA

PHR: Project Narrative Solid tumors cause over 1,500 deaths per day in the United States highlighting a profound, unmet need for new therapies. Our company’s long-term goal is to produce an affordable, chemo-/cell- free treatments that harness the immune system to fight solid tumors.

PI_NAMEs: ERFAN, DASHTIMOGHADAM  (contact);MAJEDI, FATEMEH SADAT

PROGRAM_OFFICER_NAME: CONNORS, BRITTANY SEAN

PROJECT_TERMS: 4T1;Abscopal effect;Adjuvant;Adverse effects;Affect;Alginates;Antibodies;arm;Autoimmune;Biocompatible Materials;biocompatible polymer;biodegradable polymer;Biological Sciences;Biomedical Engineering;Biopsy;Breast Cancer Model;cancer infiltrating T cells;Canis familiaris;CAR T cell therapy;Caring;Cells;Certification;Cessation of life;chemotherapy;Clinical Trials;cytokine release syndrome;Cytotoxic T-Lymphocytes;Data;design;Development;Devices;Distant;Distant Metastasis;Drug Kinetics;Early treatment;effector T cell;Endowment;engineered T cells;exhaustion;Exons;experience;fighting;Flow Cytometry;Formulation;Funding;Goals;Hematologic Neoplasms;Histology;Human;Immune;Immune system;Immunity;Immunologics;immunoregulation;Immunotherapy;Implant;improved;In Situ;Incubators;Infiltration;inhibitor;innovation;LoxP-flanked allele;lymph nodes;Lymphocyte;Lymphoma;Malignant Breast Neoplasm;Malignant Neoplasms;manufacturability;manufacture;Mechanics;Melanoma;Metastatic breast cancer;Modality;mouse model;Mus;Myelogenous;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;novel therapeutics;Operative Surgical Procedures;Outcome;particle;patient derived xenograft model;Performance;Phase;Pilot Projects;polyoma middle tumor antigen;Porifera;pre-Investigational New Drug meeting;Rattus;recruit;Regulatory T-Lymphocyte;response;scaffold;Secure;side effect;Site;Solid Neoplasm;standard of care;T cell response;T-Cell Activation;T-Lymphocyte;Techniques;Testing;Time;Toxic effect;Transforming Growth Factor beta;Translating;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;Tumor Suppression;tumor-immune system interactions;United States;Work

PROJECT_TITLE: Immunomodulatory biomaterial to enhancing T-cell responses to triple negative breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-R(12)B]


ORG_CITY: LUBBOCK

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

ORG_STATE: TX

PHR: Project Narrative: This proposal aims to understand how secretory and membrane proteins are properly synthesized and folded in the endoplasmic reticulum (ER). The ER-resident sensor molecules monitor and adjust the protein folding capacity of the ER according to demand. We previously discovered that one of the sensor molecules, IRE1, forms a direct complex with the protein translocation machinery in the ER. In this proposal, we will mechanistically understand how both IRE1 and protein translocation machinery work together to maintain ER homeostasis, which is fundamentally important for producing functional molecules, including antibodies, hormones, and transport proteins.

PI_NAMEs: MARIAPPAN, MALAIYALAM  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TITLE: The interplay between the UPR and protein biogenesis at the ER

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Duke University, a major research university, and North Carolina Central University, a historic black university, both in Durham, NC partner for this career development program in women’s health research. Selected junior faculty members and one postdoctoral trainee from these two institutions receive formal mentoring and training to conduct interdisciplinary research relevant to women’s health across the lifespan emphasizing health disparities and the effects that sex and gender have on health. These well- trained scientists will be the future champions for improving women’s health nationwide and globally.

PI_NAMEs: AMUNDSEN, CINDY  (contact)

PROGRAM_OFFICER_NAME: TIGNO, XENIA

PROJECT_TERMS: Address;Administrative Supplement;Advisory Committees;Affect;Appointment;Behavioral;career;career development;Career Mobility;Clinical;Clinical Services;Collaborations;Evaluation;Faculty;Fostering;Foundations;Funding;Future;Gender;gender difference;Goals;Grant;hands on research;Health Disparities Research;health disparity;Health Services Research;Historically Black Colleges and Universities;human disease;innovation;Institution;interdisciplinary approach;Interdisciplinary Study;interest;Journals;Lead;Leadership;Learning;life span;Mentored Clinical Scientist Development Program;Mentors;Monitor;North Carolina;Peer Review;Postdoctoral Fellow;programs;Publishing;recruit;Research;Research Institute;Research Personnel;Science;Scientist;sex;skills;social science research;Structure;success;Training;Universities;Women's Health;Work;Writing

PROJECT_TITLE: Building Interdisciplinary Research Careers in Women's Health (K12) - Administrative Supplement


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: MEMPHIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: New Methods and Chemical Tools Against Multi Drug-resistant Bacterial Infections Project Narrative/Relevance Multi-drug resistance bacterial infections are a global health crisis that urgently needs new antibacterials with novel mechanisms of action. This proposal outlines our approach to identifying new and effective antibacterials via an innovative targeted protein degradation strategy and inhibiting novel bacterial targets using the 19F NMR ligand screening platform.

PI_NAMEs: ROY, SUDESHNA  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Address;Alkenes;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Area;Award;Bacterial Drug Resistance;Bacterial Infections;Biological;Cell Wall;Cellular Structures;Chemicals;Collaborations;cost;Disparate;Environment;Enzymes;Evolution;fascinate;Fostering;Future;global health;Goals;graduate student;Healthcare Industry;Heterocyclic Compounds;human disease;innovation;insight;International;Learning;Ligands;Medicine;Methods;Multi-Drug Resistance;multidisciplinary;new chemical entity;Nitrogen;novel;Postdoctoral Fellow;programs;Property;protein degradation;rational design;Research;resistant strain;Science;screening;skills;small molecule;Structure;tool;undergraduate student;United States;Universities;Work

PROJECT_TITLE: Expanding the small molecule toolbox through novel applications of fluorinated alkenes

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Human Genome

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Not Applicable

PI_NAMEs: KARLSSON, ELINOR  (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Address;Adult;Animal Behavior;Behavior;behavior observation;Behavioral;behavioral genomics;behavioral phenotyping;Biological Assay;Biology;Black Box;Brain region;Canis familiaris;Code;Collaborations;Communities;community science;Complex;curriculum development;Data;Data Set;data visualization;Development;Etiology;Evolution;Exhibits;experience;Experimental Designs;Genes;Genome;genome sciences;genome wide association study;genomic locus;Genomics;Genotype;Goals;Habitats;Hour;Human;Hybrids;innovation;insight;interdisciplinary approach;Language;Life;Manuals;Maps;mathematical model;mobile app development;Motor;Pathway interactions;Pattern;phenome;Phenotype;phenotypic data;Population;Predatory Behavior;Privatization;pup;Recording of previous events;Regulatory Element;Research;Scientist;Speech Development;System;Testing;trait;Variant;whole genome;wolves

PROJECT_TITLE: Collaborative Research: EDGE CMT: Utilizing adaptive variation in predatory behavior to uncover the relationship between genes and complex behavioral phenotypes


ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Mutations in proteins inducing widespread transcriptomic or genomic changes are widely implicated in human disease. However, determining which mutations are pathogenic vs. benign remains a significant challenge in clinical applications of next-generation sequencing analysis. This project develops complementary pooled genome editing and computational approaches to interpret the impact of individual mutations to regulatory and DNA repair genes.

PI_NAMEs: GOREN, ALON  (contact);GYMREK, MELISSA ;KOMOR, ALEXIS C.

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Address;Affect;base editing;base editor;Benign;biobank;Biological Assay;Candidate Disease Gene;candidate identification;Categories;Cell model;cell type;Cells;Chemicals;Chromatin;Clinical;clinical application;clinically actionable;Code;cohort;computational pipelines;Computing Methodologies;CRISPR/Cas technology;Custom;Data Set;design;Detection;Development;Diagnostic;disorder risk;DNA Repair;DNA Repair Gene;EP300 gene;ERCC2 gene;follow-up;functional genomics;Gene Targeting;Genes;genetic regulatory protein;Genetic Transcription;genetic variant;Genome;genome editing;genome sequencing;Genome Stability;Genomic approach;genomic data;Genomics;Genotype-Tissue Expression Project;high throughput technology;Human Cell Line;human disease;human embryonic stem cell;human female;Human Genetics;human genomics;Individual;Induced Mutation;insight;interest;knockout gene;Laboratories;large datasets;Libraries;Link;male;Maps;Methods;Methyl-CpG-Binding Protein 2;Minority;MLL2 gene;model organism;Molecular Biology;MSH2 gene;Mutation;mutation screening;next generation sequencing;Pathogenicity;Patients;Phenotype;precision medicine;Process;Proteins;Quantitative Trait Loci;rare variant;Regulator Genes;Regulatory Element;Reporting;Rett Syndrome;Severities;single cell ATAC-seq;single cell sequencing;Single Nucleotide Polymorphism;single-cell RNA sequencing;Somatic Mutation;Technology;trait;Trans-Activators;transcription factor;transcriptomics;Variant;variant of interest;variant of unknown significance;whole genome;Xeroderma Pigmentosum

PROJECT_TITLE: A framework for interpreting global effects of genetic variants contributing to disease risk

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Narrative Over the last twenty years from the early days of linkage and candidate gene studies to the ongoing whole- genome sequencing efforts, the family-based association testing (FBAT) approach and its software implementation have become a popular and essential tool for the genetic association analysis of family data. The model-free character of the approach, its robustness against any form of genetic confounding, and the user- friendly implementation have fostered the research of a large user community and contributed to several thousand research papers. In this application, to better address the current and future data analysis challenges of the community, we propose to modernize the FBAT program by incorporating new methodological features and improving the technical capabilities of the implementation.

PI_NAMEs: LANGE, CHRISTOPH  (contact)

PROGRAM_OFFICER_NAME: ZHANG, LI

PROJECT_TERMS: Address;Affect;Alleles;biobank;Candidate Disease Gene;Childhood;cluster computing;Communities;Complex;Computer software;conditioning;Data;Data Analyses;design;Disease;Disease susceptibility;Documentation;dosage;Family;file format;Fostering;Future;General Population;Genetic;genetic analysis;genetic association;Genetic Diseases;genetic pedigree;Genetic Structures;Genome;genome sequencing;genome wide association study;genome-wide;genomic locus;Genomic Segment;Genotype;Haplotypes;Human Genome Project;improved;Individual;interest;Joints;Laws;learning materials;Licensing;Linkage Disequilibrium;Linux;Machine Learning;Maps;Mendelian randomization;Methodology;Modeling;Modernization;multidimensional data;Nuclear Family;offspring;open source;Outcome;Output;Paper;parallel computer;parallelization;Parents;phenome;Phenotype;Play;pleiotropism;Population;Population Control;Preparation;programs;Rare Diseases;rare variant;Reporting;Research;Research Project Grants;Role;Sample Size;Sampling;screening;Signal Transduction;Source Code;Specific qualifier value;statistics;stem;Structure;Susceptibility Gene;Testing;Text;tool;Traction;Training;trait;transmission process;Underrepresented Populations;Update;user friendly software;user-friendly;Variant;web page;whole genome

PROJECT_TITLE: Modernizing the family-based association testing (FBAT) approach and its software implementation in the FBAT-program

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE In this administrative supplement to our UC Davis BIRCWH program (PI, Dr. Nancy Lane), we propose to build on the experience and achievements of our previous 21 years of the program to advance, promote, and achieve interdisciplinary training and mentoring of team-based science for the next generation of researchers in women's health and sex differences. We are requesting to continue supporting our BIRCWCH Scholar who is from an underrepresented minority group and disadvantaged background to our program for two years. We believe that our BIRCWH faculty, mentors, and this additional Scholar will work to improve the health of women and to improve our knowledge and understanding of the mechanisms and manifestations of sex differences in health and disease as well as of the unique afflictions women face with the ultimate goal of more effective prevention, diagnosis, and treatment.

PI_NAMEs: LANE, NANCY E (contact)

PROJECT_TERMS: Academy;Address;Administrative Supplement;Area;Biometry;Breast Feeding;California;career;career development;clinical practice;Collaborations;Development Plans;disadvantaged background;Environment;ethnic minority;evidence base;experience;Female;Fostering;Foundations;Gender;gender difference;gender disparity;Grant;health difference;health disparity;improved;innovation;Interdisciplinary Study;interest;Journals;Knowledge;medical schools;meetings;Mentored Clinical Scientist Development Program;Mentors;Minority Groups;Pathway interactions;programs;racial minority;Research;research and development;Research Personnel;responsible research conduct;Schools;Science;sex;Sex Differences;symposium;Training;Translating;Underrepresented Minority;United States National Institutes of Health;Women's Health;Writing

PROJECT_TITLE: Building Interdisciplinary Research Careers in Women's Health at UC Davis


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Aligning with the 2019-23 Trans-NIH Plan for Women’s Health Research, the long-term objective of the UIC BIRCWH is to promote training and careers to develop a well-trained, diverse, and robust workforce to advance science for the health of women. Through evidence-based mentoring practices, innovative training strategies, and strong internal and external multidisciplinary collaborations, the UIC BIRCWH improves recruitment, retention, and advancement of women and URMs as scientists and academic leaders in interdisciplinary women’s health and sex/gender differences research.

PI_NAMEs: BUHIMSCHI, IRINA A;MAKI, PAULINE M (contact)

PROJECT_TERMS: Acceleration;Address;Administrative Supplement;Appointment;Black race;black women;cardiometabolic risk;career;career development;cohort;college;didactic education;dietary;Disease;Doctor of Philosophy;evidence base;Faculty;Female;Funding;Gender;Generations;Gestational Diabetes;Goals;Grant;Health;health disparity;Health Sciences;Healthcare;Hispanic;improved;Individual;Interdisciplinary Study;Knowledge;knowledge translation;lifestyle intervention;Malignant neoplasm of cervix uteri;Medicine;Mentors;Nature;Pharmacy facility;Physicians;Positioning Attribute;Postdoctoral Fellow;pregnant;prevent;Professional Competence;professor;programs;Research;Research Personnel;Science;Scientist;Secure;sex;success;tenure track;tool;Training;United States National Institutes of Health;Woman;Women's Health

PROJECT_TITLE: UIC Building Interdisciplinary Research Careers in Women's Health Program


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: MILWAUKEE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: The Medical Science Training Program (MSTP) at the Medical College of Wisconsin (MCW) provides integrated basic science and medical training as the educational foundation for future academic physician scientists. The mission of MCW-MSTP is to prepare students for careers as physician-scientists, which allows students to conduct hypothesis-driven research and to practice evidence-based medicine as an MD-PhD. MCW-MSTP welcomes all applicants, including students of diversity, students with disabilities, and students from socio-economically disadvantaged backgrounds.

PI_NAMEs: BARBIERI, JOSEPH T;SALZMAN, NITA H (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: WILMINGTON

ORG_NAME: NEMOURS CHILDREN'S HOSPITAL, DELAWARE

ORG_STATE: DE

PI_NAMEs: HILDENBRAND, AIMEE K (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TITLE: Empowering adolescents and young adults with sickle cell disease as partners in treatment decision making (EMPOWER-AYA)


PI_NAMEs: GUARINO, STEPHANIE HOWE (contact)

PROJECT_TITLE: Chronic Pain and Self-Efficacy: A Peer Mediated Group Intervention for Adults with Sickle Cell Disease


PI_NAMEs: JIN, JING  (contact)

PROJECT_TITLE: The eye as a window into sickle cell disease morbidity


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Burden of Illness;Clinical Research;Health Services;Hematology;Prevention;Rare Diseases;Sickle Cell Disease

PI_NAMEs: GWARZO, IBRAHIM HALIRU (contact)

PROJECT_TERMS: Accident and Emergency department;acute care;Adult;Age;Caring;Characteristics;Child health care;Chronic;Clinical;Code;Collaborations;Collection;County;Cross-Sectional Studies;Data;Data Sources;Databases;Delaware;Diagnosis;disparity reduction;Epidemiology;Ethnic Origin;Foundations;Funding;Health;health care service utilization;Health Services Accessibility;Healthcare;Healthcare Systems;Hospitals;ICD-9;Improve Access;Individual;Information Networks;Infrastructure;Inpatients;International Classification of Diseases;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);intervention program;Laboratories;life span;Location;Medicaid;Medicine;Modification;Neonatal Screening;Outpatients;Patients;Pattern;Persons;Population;Probability;programs;Quality of life;Race;Records;Research;Research Personnel;screening program;sex;Sickle Cell;Sickle Cell Anemia;Source;surveillance data

PROJECT_TITLE: Epidemiologic burden of Sickle Cell Disease: Evaluating Healthcare Utilization of Persons with Sickle Cell Disease in Delaware


ACTIVITY: ZIA

FUNDING_MECHANISM: INTRAMURAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Eczema / Atopic Dermatitis;Genetics;Human Genome;Infectious Diseases;Microbiome;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

PI_NAMEs: SEGRE, JULIA ANGELA (contact)

PROJECT_TERMS: Acne;Affect;Aftercare;Allergic rhinitis;Animal Model;Asthma;Atopic Dermatitis;Bacteria;bacterial community;Bacteriophages;Biological Markers;Biology;Characteristics;Child;Clinical;Clinical Research;Collaborations;Communities;congenital immunodeficiency;Corynebacterium;Cutaneous;Data;Disease;Disease Progression;Ecology;Eczema;experimental analysis;Flare;fungus;Future;gene environment interaction;Genes;Genetic;Genome;genome analysis;Genomics;Genus staphylococcus;Goals;Hay fever;healthy volunteer;Hematopoietic Stem Cell Transplantation;host-microbe interactions;Human;human disease;Human Papillomavirus;improved;In Vitro;Individual;individual patient;Infant;insight;Investigation;Laboratories;Life;longitudinal analysis;Longitudinal Studies;Malassezia;metagenome;metagenomic sequencing;Metagenomics;Methods;Microbe;microbial;microbial community;microbiome research;microbiota;novel;Organism;pathogen;patient population;Patients;Physiology;Population;Propionibacterium;Resolution;Ribosomal RNA;Role;Sequence Analysis;Severity of illness;Shotguns;Skin;skin microbiome;skin microbiota;Staphylococcus aureus;Staphylococcus epidermidis;Surface;tool;transcriptome sequencing;Viral;virome;Virus Diseases

PROJECT_TITLE: Gene-Environment Interactions at the Skin Surface


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PI_NAMEs: BURGESS, SHAWN M (contact)

PROJECT_TERMS: arm;base;base editor;Blood capillaries;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Computer software;cost effective;CRISPR/Cas technology;Data;Drops;Enhancers;functional genomics;gene function;Gene Targeting;Genes;Genetic Diseases;Genetic Screening;Genome;genome-wide;genomic locus;Germ Lines;Goals;Hearing;high throughput technology;human disease;Human Genetics;human model;improved;in vivo;Knock-in;Knock-out;knockout gene;Length;Modeling;Mutagenesis;Mutation;Natural regeneration;prime editor;Process;programs;Publications;reference genome;Research;Resources;Rest;site-specific integration;Techniques;Technology;telomere;Testing;tool;Transgenes;transmission process;Writing;Zebrafish;zebrafish genome

PROJECT_TITLE: Zebrafish targeted mutagenesis and functional genomics


PI_NAMEs: OSTRANDER, ELAINE  (contact)

PROJECT_TERMS: Accidents;Admixture;Adult;Affect;Age;age related changes;Aging;aging reversal;American;Americas;Architecture;Area;autosome;Bacteria;Behavior;Behavioral;Biologic Characteristic;biological age;Biological Aging;Biology;Body Size;Breeding;cancer genetics;Cancer Patient;cancer risk;candidate identification;Canis familiaris;Carcinoma;Chernobyl Nuclear Accident;Chronology;Cities;citizen science;Clams;Clinical;cohort;Collaborations;Communicable Diseases;Communities;companion animal;comparative genomics;Complex;Contracts;Cytosine;Data;Data Commons;Demography;Development;Developmental Process;Diagnosis;Disease;Disease susceptibility;disorder risk;DNA;DNA Sequence;dog genome;Dose;Enhancers;Environment;Environmental Pollution;epigenetic aging;epigenetic clock;epigenome;Epilepsy;Evolution;expectation;experimental study;Exposure to;Galapagos Islands;General Population;Genes;Genetic;genetic risk factor;Genetic study;genetic variant;Genome;genome repository;genome sciences;genome sequencing;genome-wide;genome-wide analysis;genomic data;Genomic Segment;Genomics;Geography;Greenland;Haplotypes;Health;Histiocytic sarcoma;Histopathology;Home;Human;Human Biology;human disease;Human Genetics;human migration;human mortality;Indigenous;Individual;insertion/deletion mutation;insight;interest;Intervention;Interview;Ionizing radiation;life span;Livestock;London;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mammals;Measurement;Measures;Mediating;Methylation;migration;Mitochondria;Modernization;Molecular;Morphology;mortality risk;multiple omics;muscle invasive bladder cancer;Mutation;Neoplasm Metastasis;Nuclear Accidents;Nucleotides;overexpression;Pattern;Persons;Phenotype;Phylogenetic Analysis;Point Mutation;Polymerase;Population;Population Genetics;population stratification;Power Plants;predictive modeling;pressure;Prevalence;Prions;programs;Proteins;Publishing;Reagent;Recording of previous events;reference genome;Regional Disease;repetitive behavior;Reporting;repository;Research;Research Design;Research Personnel;Rest;Risk;risk variant;Sampling;sex;Shapes;Site;Sledding;social media;Structure;Survival Rate;System;Tissues;tool;trait;treatment response;tumor;Ukraine;unsupervised clustering;Untranslated RNA;urinary;Variant;Viral;webinar;Weight;whole genome;Work;Writing;X Chromosome

PROJECT_TITLE: Cancer Genetics and Comparative Genomics


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Health Services;Human Genome;Infectious Diseases;Microbiome;Patient Safety;Prevention

PROJECT_TERMS: Antibiotic Resistance;antimicrobial;Bacterial Infections;Candida auris;carbapenem resistance;Cessation of life;clinical care;clinical center;clinical epidemiology;Collaborations;colonization resistance;cost;Development;Diagnostic;Disease Outbreaks;Ecosystem;emerging human pathogen;Emerging Technologies;epidemiologic data;Epidemiology;Evolution;Family;Genetic;Genetic Variation;Genome;genome sequencing;Genomic approach;genomic data;Genomics;Goals;Health care facility;Healthcare;Hospitals;Human;Human Microbiome;improved;In Vitro;Infection;Infection Control;insight;Intervention;Klebsiella pneumoniae;Laboratories;Metadata;metagenome;metagenomic sequencing;Metagenomics;Methods;Microbe;microbial colonization;microbial community;microbial genome;microbial genomics;Mission;Modeling;Monitor;mouse model;Multi-Drug Resistance;Mycoses;Nosocomial Infections;novel;Nursing Homes;Organism;pathogen;pathogenic bacteria;pathogenic fungus;Patient Care;patient population;patient safety;Patients;Pharmaceutical Preparations;Physicians;prevent;reference genome;resistant Klebsiella pneumoniae;Resolution;Risk Assessment;Scientist;Shotguns;Site;Skin;Skin colonization;social;Sphingomonas;Symbiosis;Testing;Translating;transmission process;United States;United States National Institutes of Health;whole genome

PROJECT_TITLE: Microbial genomics of hospital-associated pathogens


PROJECT_TERMS: Ablation;Adult;Aerobic;Affect;Alleles;ATAC-seq;blastema;Candidate Disease Gene;Cell Death;Chemical Exposure;Chemicals;Cisplatin;Communities;Copper;CRISPR/Cas technology;Data;Defect;Development;Diphtheria Toxin;ear development;Embryo;Embryology;experimental study;Exposure to;FDA approved;Fertilization;Fertilization in Vitro;Fishes;functional genomics;Gene Expression;Gene Expression Profiling;Gene Silencing;Genes;Genetic;Genetic Transcription;Genomics;Goals;hair cell regeneration;Hair Cells;Hearing;Human;Inbreeding;inhibitor;Injury;Insertional Mutagenesis;interest;Labyrinth;lateral line;Link;Losartan;Mammals;Measurable;Measures;Messenger RNA;Metabolic;model organism;Molecular;Morphology;mutant;Mutate;Mutation;Natural regeneration;Nature;neuromast;NF-kappa B;normal hearing;offspring;Organ;otoprotectant;ototoxicity;Parents;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiology;pleiotropism;prevent;Process;receptor;Recovery;Regenerative response;Research;Respiration;Role;screening;Sensory Receptors;Siblings;Signal Pathway;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;sound;Startle Reaction;stem cell niche;Testing;TGF-beta type I receptor;tissue regeneration;Transforming Growth Factor beta Receptors;Visual;Work;wound healing;Zebrafish;zebrafish genome

PROJECT_TITLE: Hearing regeneration in zebrafish


NIH_SPENDING_CATS: Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SOLOMON, BENJAMIN  (contact)

PROJECT_TERMS: Artificial Intelligence;Biological;Biology;Clinical;Collaborations;Data;Data Set;deep learning;Disease;Electronic Health Record;Extramural Activities;Face;flexibility;Genetic Diseases;Genomics;Goals;Health;Human;Image;implementation research;improved;insight;Institutional Review Boards;interest;Investigation;Medical;Medical Genetics;Medical Records;Methods;Modeling;multiple data types;novel;Optical Coherence Tomography;Paper;Phenotype;Protocols documentation;Publishing;Research;skin lesion;Standardization;Terminology;Testing;Text;United States National Institutes of Health;Work

PROJECT_TITLE: Medical Genomics Unit Analytic Projects


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetics;Human Genome;Neurosciences;Pediatric;Rare Diseases

PI_NAMEs: GAHL, WILLIAM  (contact)

PROJECT_TERMS: 10 year old;12 year old;13 year old;3 year old;4-Aminopyridine;9 year old;Achievement;Address;adenosine deaminase deficiency;Adult;Advocacy;Anesthesia procedures;Argentina;Artificial Intelligence;Asian;Atrophic;Auditory Brainstem Responses;Autoimmune encephalitis;Award;Axon;Base Sequence;Benign;Bioinformatics;Biopsy;boys;brain magnetic resonance imaging;Brain Stem;Brazil;Brothers;Calciphylaxis;Cardiac;Caring;Cell Polarity;Cerebellar Ataxia;cerebral atrophy;Child;Childhood;China;Clinical;Clinical Protocols;Clinical Research;cohort;Collaborations;Communication;Communities;Complex;Congo;Copy Number Polymorphism;D4Z4;data sharing;Defect;Demyelinations;Dental;design;Detection;Diagnosis;Diagnostic;diagnostic tool;Disease;disease-causing mutation;Doctor of Philosophy;doctoral student;Drosophila genus;Dysarthria;Dysmetria;early onset;Endoplasmic Reticulum;Ensure;Epigenetic Process;epileptic encephalopathies;Epstein-Barr Virus Infections;experience;Face;Family;Family member;fibroblast growth factor-14;follow-up;Fostering;Foundations;Gait Ataxia;gene function;gene product;Genes;Genetic;genetic counselor;Genetic Diseases;Genome;Genome Data Analysis Network;genomic tools;Genomics;Ghana;girls;Glutaminase;glutathione peroxidase;glycosylation;Goals;Hairy Cell Leukemia Variant;health disparity;Heterozygote;Human Biology;Human Genetics;Image;Immunology;Improve Access;improved;India;inhibitor;innovative technologies;Innovative Therapy;insight;interdisciplinary collaboration;International;Internist;Intramural Research Program;Journals;KBG syndrome;Knowledge;Limb structure;Limb-Girdle Muscular Dystrophies;Link;Machine Learning;Magnetic Resonance Imaging;Mali;Medical;Medical Genetics;Medical Students;meetings;member;Membrane Potentials;Methodology;Minority Groups;model organism;Motor;MRI Scans;Muscle;Muscle hypotonia;Mutation;Myoclonic Epilepsies;Myopathy;nanopore;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;National Institute of Allergy and Infectious Disease;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Neurologic;Neurologist;Neurology;Newly Diagnosed;novel;Nucleotides;older men;operation;Pakistan;Pathogenicity;Pathologic Nystagmus;Patients;Phase;Phenotype;Phosphotransferases;Physicians;Plasma;Plasma Cells;Polyneuropathy;Postbaccalaureate;Potassium Channel;Potassium Channel Blockers;Predisposition;prevent;Procedures;Process;Progeria;Program Reviews;programs;Publishing;Rare Diseases;reduce symptoms;Reporting;Research;Research Personnel;Research Project Grants;Resources;Rheumatology;RNA Splicing;Rome;Running;Schools;Scientist;Secure;Selenium;selenoprotein;Sensory;sensory neuropathy;Series;Serum;side effect;Site;skeletal;Skeletal Muscle;skills;Skin;skin biopsy;skin ulcer;Societies;Sodium Channel;Son;Specimen;Spinal Puncture;Spinocerebellar Ataxias;STAT4 gene;Support System;symposium;Systemic disease;Taiwan;Taxes;Techniques;Technology;Thailand;Therapeutic;TNF gene;tool;Topoisomerase III;Training;Training Programs;transcriptome sequencing;transcriptomics;Translational Research;translational research program;Underserved Population;United States National Institutes of Health;Update;Variant;Visceromegaly;Walking;Washington;working group

PROJECT_TITLE: Undiagnosed Diseases Program


ACTIVITY: ZIC

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Biotechnology;Brain Disorders;Genetics;Hematology;Human Genome;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases

PI_NAMEs: BAXEVANIS, ANDREAS  (contact)

PROJECT_TERMS: 3-Dimensional;Address;African ancestry;Alleles;Animals;Archives;Area;ATAC-seq;Attention deficit hyperactivity disorder;Autopsy;behavioral study;Binding;Bioinformatics;Blood Platelet Disorders;bone cell;brain tissue;Canis familiaris;CBFbeta-MYH11 fusion protein;Cells;Child Care;ChIP-seq;Chromatin;Classification;Clinical Data;Clinical Research;cohort;Collaborations;Collection;Communities;Computer Analysis;Computer software;computerized tools;computing resources;Data;Data Analyses;Data Collection;data portal;Data Set;Databases;design;Development;Diagnosis;DNA;DNA Methylation;Education;Event;exome;Familial Platelet Disorder;Frequencies;Gene Expression;Gene Frequency;gene network;gene therapy;Genes;Genetic Diseases;Genetic Transcription;Genome;genome-wide;genomic data;Genomic Segment;Genomics;Goals;Haplotypes;health assessment;healthy volunteer;Histocompatibility;Individual;Inherited;innovation;inorganic phosphate;integration site;Investigation;Knock-in Mouse;Laboratories;Length;leukemia;Longitudinal Studies;Maintenance;Maps;Medical;Metabolic Diseases;Methodology;Methods;Mitochondrial Diseases;Mnemiopsis;Modeling;Mutation;Myeloproliferative disease;National Human Genome Research Institute;neural;Neurons;Parents;patient derived induced pluripotent stem cells;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Phenotype;protein structure prediction;Proteome;Protocols documentation;pyruvate dehydrogenase;Recording of previous events;Regulation;Reporting;Research;Research Personnel;Research Support;Retrieval;RUNX1 gene;Sampling;Security;sex determination;single-cell RNA sequencing;Surveys;T memory cell;T-Lymphocyte;transcriptome;transcriptome sequencing;United States National Institutes of Health;Update;Variant;web interface;web site;website development;Youth;Zebrafish

PROJECT_TITLE: NHGRI/DIR Bioinformatics and Scientific Programming Core


PI_NAMEs: GARRETT, LISA  (contact)

PROJECT_TERMS: Alleles;Animals;Archives;Area;Bacteria;Breeding;Cell Line;Cells;Chimera organism;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Cryopreservation;design and construction;Disasters;Dissection;DNA;Electroporation;Embryo;embryo cell;embryonic stem cell;ES Cell Line;experimental study;Facial vein structure;Female;Fertilization in Vitro;Fibroblasts;Freezing;Gene Modified;Gene Targeting;Gene Transfer Techniques;Generations;Genes;Genetic Diseases;Genetically Engineered Mouse;genome editing;Genotype;Goals;Guide RNA;Harvest;Human Genetics;Hybrid Cells;Hybrids;immunocytochemistry;in utero;In Vitro;in vivo;induced pluripotent stem cell;inhibitor;Injections;Knockout Mice;Location;male;MAP Kinase Gene;Methods;model organism;Modeling;mouse model;Mus;mutant mouse model;Mutant Strains Mice;National Human Genome Research Institute;Natural Immunity;nuclease;Pathway interactions;pluripotency;Procedures;Production;programs;Protocols documentation;Reagent;Research;Research Personnel;Research Support;Services;Site;sperm cell;Standardization;stem cell technology;System;Techniques;Technology;Teratoma;Time;Transfection;Transgenic Mice;Transgenic Organisms;user-friendly;Work;zygote

PROJECT_TITLE: NHGRI/DIR Embryonic Stem Cell and Transgenic Mouse Core


PI_NAMEs: SOOD, RAMAN  (contact)

PROJECT_TERMS: Adult;Alleles;Antibodies;base editing;Biological Assay;Candidate Disease Gene;Chemicals;Clip;Collection;CRISPR/Cas technology;Cryopreservation;design;Developmental Delay Disorders;Disaster Planning;Disease;Dissection;DNA;DNA Repair;Electroconvulsive Therapy;Embryo;Ensure;Evaluation;Event;experimental study;FANCD2 protein;Fertilization in Vitro;Fishes;Functional disorder;functional genomics;Gene Transfer Techniques;Generations;Genes;Genetic Diseases;genome editing;Genomic approach;Genotype;Heat-Shock Response;human model;Image;Immunohistochemistry;In Situ;In Situ Hybridization;International;Kidney;Knock-in;Knock-out;knockout gene;Maintenance;Melanoma;Microinjections;Microscope;Mutagenesis;mutant;National Human Genome Research Institute;novel therapeutics;nuclease;Oligonucleotides;overexpression;Patients;Phenotype;plasmid DNA;Plasmids;Point Mutation;Procedures;Process;Protocols documentation;Research Personnel;Resources;RNA;Role;RUNX1 gene;Safety;Sampling;screening;Services;Shipping;small molecule;Source;System;Techniques;Testis;Tissues;tool;Training;transcriptome sequencing;Transgenic Organisms;Variant;Zebrafish

PROJECT_TITLE: NHGRI/DIR Zebrafish Core


ACTIVITY: ZID

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Services;Human Genome;Patient Safety

PROJECT_TERMS: Academic support;Accreditation;acute care;Administrative Personnel;Adverse event;Annual Reports;Area;Awareness;Biochemical;Bioethics;care providers;Clinical;clinical center;clinical database;clinical infrastructure;Clinical Investigator;Clinical Management;Clinical Protocols;Clinical Research;Clinical Trials Data Monitoring Committees;clinically significant;Congresses;Consultations;Contracts;COVID-19 pandemic;Credentialing;Data;data exchange;data management;design;Development;Diagnosis;Discipline;Disease;Education;Electronic Mail;Ensure;Event;Fellowship;flexibility;Genetic;genetic counselor;Genetic Diseases;Genetic Services;genetic testing;Genomics;Glycosphingolipids;Goals;Health;Health care facility;Health Personnel;Health Professional;Hospitals;Information Systems;Institutional Review Boards;Intervention Trial;Laboratories;laboratory facility;Licensing;Logistics;Medical;Medicine;meetings;member;Monitor;National Human Genome Research Institute;Natural History;Nurse Practitioners;Nursing Research;Other Genetics;pandemic disease;Paper;Patient Recruitments;patient safety;Patients;Pediatrics;Performance;Physicians;Policies;Principal Investigator;Process;programs;Protocols documentation;Reporting;Research;research clinical testing;research facility;Research Personnel;Research Project Grants;Residencies;Review Committee;Schedule;Scientific Advances and Accomplishments;Services;Supervision;System;Telephone;Testing;Training;Training Programs;Translational Research;Travel;United States National Institutes of Health;virtual;Writing

PROJECT_TITLE: NHGRI/DIR Clinical Support Services


ACTIVITY: ZIE

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Health Services;Human Genome;Pediatric;Social Determinants of Health

PI_NAMEs: SHCHELOCHKOV, OLEG  (contact)

PROJECT_TERMS: Accreditation;Age;American;Area;Baltimore;Biochemical Genetics;Board Certification;Books;Budgets;care outcomes;career;Caring;Certification;Child;Clinical;clinical center;Clinical Research;clinical training;Collection;community based care;Community Health;Counseling;Diagnostic;District of Columbia;Diverse Workforce;Doctor of Philosophy;Education;Eligibility Determination;Enrollment;Environment;epidemiology study;Evaluation;experience;Faculty;Family;Fellowship;Fostering;Future;Genetic;Genetic Medicine;Genomic medicine;Genomics;Goals;graduate medical education;Health;health equity promotion;Health Professional;Health system;Healthcare;Home;Hospitals;improved;Individual;Infertility;Infrastructure;Inpatients;Instruction;Laboratories;laboratory experience;Laboratory Research;learning materials;life-long learning;Maryland;Maternal-fetal medicine;matriculation;Medical;Medical Genetics;medical specialties;Medicine;meetings;metropolitan;Military Personnel;National Human Genome Research Institute;National Institute of Child Health and Human Development;Neonatal Screening;non-genetic;Outpatients;Patients;Pediatrics;Physicians;Policies;Population;Positioning Attribute;Primary Care;programs;Public Health;Reproductive Endocrinology;Research;Residencies;Rotation;Running;Schools;Scientist;Self Direction;Site;skills;Social Justice;Specialist;Time;Training;Training Programs;Training Support;Travel;underserved community;United States;United States National Institutes of Health;Universities;Virginia;Wages;Washington;Work

PROJECT_TITLE: NHGRI/DIR Medical Genetics and Genomic Medicine Training Programs


ACTIVITY: ZIG

ORG_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

PI_NAMEs: WOO, JOSEPH  (contact)

PROJECT_TERMS: Accreditation;activation-induced cytidine deaminase;Adult;Affect;Allergic rhinitis;Ambulatory Care;animal care;Animal Care and Use Committees;Animal Diseases;Animal Experimentation;animal facility;Animals;Apoptosis;Area;Arthritis;Autoimmune Diseases;Autoimmunity;Biology;Bone Development;Bone Marrow Transplantation;bone repair;Breeding;Cartilage;Chondrogenesis;chromatin remodeling;Cytoskeleton;Degenerative polyarthritis;Disease;Ensure;Equipment and supply inventories;Exclusion;experimental study;Familial Mediterranean Fever;fetal;Fostering;Genetic Recombination;Glycogen storage disease type II;growth differentiation factor 5;Guidelines;Hour;Hypersensitivity;In Vitro;Inflammatory;International;Laboratory Animals;mammalian COMP;member;Modeling;Mus;Muscle Development;Myofibrils;Myopathy;Myositis;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Organelles;Peer Review;Periodicals;Principal Investigator;Process;programs;Proteins;Rattus;receptor;Regulation;Research;research facility;Research Personnel;Research Support;response;retroviral transduction;Rodent;Sentinel;SIRT1 gene;Skeletal Muscle;skin organogenesis;Skin Tissue;Syndrome;Time;Tissue Engineering;Training Programs;Transgenic Mice;Tumor Necrosis Factor Receptor;United States National Institutes of Health;Visit;Voting;Work

PROJECT_TITLE: Animal care: supporting research on autoimmune, inflammatory and muscle diseases


ACTIVITY: ZIH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Prevention

PROJECT_TERMS: Adopted;Archives;Behavioral Research;Bioinformatics;Biological;Biometry;Clinical;clinical center;clinical database;Clinical Informatics;Clinical Protocols;Clinical Research;computer infrastructure;Computer software;computerized tools;computing resources;Data;Data Analyses;data warehouse;Databases;detection method;Development;Diagnosis;DNA Sequence;electronic data;Environment;Genetic Diseases;genetic pedigree;Genetic Research;genome sequencing;genome wide association study;genome-wide analysis;genomic data;Genomics;Health Insurance Portability and Accountability Act;Hereditary Disease;High Performance Computing;Human Genetics;Information Systems;innovation;Institution;Intramural Research;Laboratories;Metadata;Methodology;migration;molecular modeling;National Human Genome Research Institute;Online Systems;Pathway Analysis;peer;Prevention;programs;Protein Sequence Analysis;Public Domains;query tools;Research;Research Personnel;Resources;Running;scientific computing;Scientist;single cell analysis;terabyte;Translating;Translational Research;United States National Institutes of Health;Variant;whole genome

PROJECT_TITLE: NHGRI/DIR Scientific Computing


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: TUCSON

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative  The current multidisciplinary study will combine functional analyses, optogenetic techniques and molecular modeling to address successively the regulation of cardiac Ca2+-activated K+ channels in normal and failing cardiac myocytes.

PI_NAMEs: CHIAMVIMONVAT, NIPAVAN  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Address;Adrenergic Agents;Animals;Anti-Arrhythmia Agents;Area;Arrhythmia;Atrial Fibrillation;atrioventricular node;Binding;Book Chapters;Calcium-Activated Potassium Channel;Calmodulin;Cardiac;Cardiac Myocytes;Chemicals;Clinical;Coiled-Coil Domain;Compensation;Complex;Computer Models;computer studies;Cryoelectron Microscopy;Dimerization;Disease;Docking;experimental study;Feedback;Female;Functional disorder;Grant;Heart;Heart Atrium;Heart Diseases;Heart failure;Homology Modeling;Human;insight;interest;Ion Channel;Knowledge;Laboratories;Length;Libraries;male;Modeling;Molecular;molecular dynamics;molecular modeling;Motivation;multidisciplinary;Muscle Cells;Mutation;new therapeutic target;null mutation;optogenetics;Oryctolagus cuniculus;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Physiological;Potassium Channel;Process;Protein Isoforms;Publishing;receptor function;Regulation;Reporting;Role;Ryanodine Receptor Calcium Release Channel;sex;Source;Structural Models;Structure;superresolution imaging;Techniques;Testing;therapeutic target;tool;trafficking;Up-Regulation;Ventricular;voltage;Work

PROJECT_TITLE: Functional interactions of cardiac ion channels

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative  Our understanding of Treponema pallidum, and by extension syphilis, has been hindered by the lack of an in vitro culture system for over a century. The proposed research will test the hypothesis that T. pallidum naturally secretes muropeptides that drive syphilis pathogenesis. This work will therefore describe the biochemical features of released T. pallidum PG, elucidate its role in T. pallidum pathogenesis, and create a custom CRISPR platform that can be used for future investigation of T. pallidum biology.

PI_NAMEs: HAYES, KATHRYN ADAIR (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Affect;amidase;Architecture;Back;Bacteria;Biochemical;Bioinformatics;Biological Assay;Biology;Borrelia burgdorferi;Case Study;Cell division;cell growth;Cell membrane;Cessation of life;Chemicals;Chemistry;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;comparative;Congenital Syphilis;Culture Media;Custom;Cytoplasm;Delayed Hypersensitivity;Development;Disease;Endopeptidases;Environment;environmental stressor;experimental study;Future;Growth;human pathogen;Immune;Immune response;immunogenic;Immunologics;Immunomodulators;immunoregulation;In Vitro;in vivo;Incidence;Individual;Infection;Inflammation;insight;Investigation;Isotope Labeling;Knowledge;Lipopolysaccharides;Liquid Chromatography;Lyme Arthritis;Lyme Disease;lyme pathogenesis;Lytic;Membrane Proteins;Modeling;Modification;Molecular;mutant;Necrotic Lesion;Normal Cell;novel;Order Spirochaetales;Ornithine;Oryctolagus cuniculus;pathogen;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Peptides;Peptidoglycan;peptidoglycan monomer;Periodontal Diseases;Phase;Physiologic pulse;Play;Polysaccharides;Pregnancy;pressure;Public Health;Radiolabeled;Recycling;Reporter;Research;response;Role;Series;Severities;Sexual Transmission;Sexually Transmitted Diseases;stem;stillbirth;Structure;Symptoms;Syphilis;Syphilitic chancre;System;tandem mass spectrometry;Testing;Tissues;tool;Toxin;Treponema denticola;Treponema pallidum;Treponema pallidum subspecies pallidum;United States;Vertical Disease Transmission;Virulence Factors;Work;World Health Organization

PROJECT_TITLE: The natural release of Treponema pallidum peptidoglycan as a pathogenic determinant of syphilis


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_CITY: DEDHAM

ORG_NAME: CHROMATAN CORPORATION

PHR: PROJECT NARRATIVE The overall goal of the proposed Direct to Phase II SBIR project is to commercialize Continuous Countercurrent Tangential Chromatography (CCTC) for recombinant AAV purification. This novel platform will enable column-free, continuous, and single-use purification of rAAVs. Successful commercialization of the CCTC system in this field will lead to at least a 50% reduction in downstream production costs, increased recoveries (by 40%) and improved product quality for these life saving therapies that provide effective treatments and cures for such conditions as cancer, hemophilia and many others.

PI_NAMEs: SHINKAZH, OLEG  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;adeno-associated viral vector;Administrative Supplement;Affinity;Biological Assay;Bioreactors;Budgets;Buffers;Capsid;Cells;Chromatography;Column Chromatography;commercialization;cost;Data;design;Development;effective therapy;Enzyme-Linked Immunosorbent Assay;Equipment;Excision;Experimental Designs;Funding;Goals;Grant;Harvest;Hemophilia A;Hour;Immunoassay;improved;Malignant Neoplasms;manufacture;Manufacturer;Monoclonal Antibodies;next generation;novel;operation;particle;Phase;Plant Resins;Polishes;prevent;Process;Production;Productivity;Proteins;Protocols documentation;Quality of life;Recombinant adeno-associated virus (rAAV);Recovery;Research;Sampling;scale up;screening;Small Business Innovation Research Grant;System;Taxes;Techniques;Technology;Therapeutic;Time;United States National Institutes of Health;Viral

PROJECT_TITLE: Resubmission - Development and scale-up of Continuous Countercurrent Tangential Chromatography (CCTC) for next generation AAV vector manufacturing (Direct to Phase II)


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BATON ROUGE

ORG_DEPT: PATHOLOGY

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Project narrative: Antimicrobial resistance in bacteria has become a significant concern in human health. The lack of antimicrobial stewardship and increased use of antimicrobial drugs in animal feeds has led to the emergence of antibiotic-resistant bacterial pathogens from companion and food-producing animals. The availability of benchtop DNA sequencing platforms provides an accurate whole- genome sequence (WGS) for a broad range of bacteria in less than a day. Thus, identifying genetic determinants of antimicrobial resistance and typing of clinically critical bacterial pathogens help accurately define the transmission of drug-resistant and multi-drug-resistant organisms. The work performed under this project will allow a continuing collaboration with Center for Veterinary Medicine’s Vet-LIRN into investigating of human and animal food safety using Whole Genome Sequencing (WGS).

PI_NAMEs: BALASURIYA, UDENI B. R. (contact)

PROGRAM_OFFICER_NAME: CERIC, OLGICA

PROJECT_TITLE: Vet-LIRN Network Capacity-Building Project: Bacterial Whole Genome Sequencing


ORG_CITY: REYNOLDSBURG

ORG_NAME: OHIO STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: OH

PHR: FDA CVM Vet-LIRN PROGRAM (U18) GRANT PROPOSAL  FOR FOA # PAR-22-063 from the OHIO DEPARTMENT OF AGRICULTURE, ANIMAL DISEASE DIAGNOSTIC LABORATORY PROJECT NARRATIVE The FDA Veterinary Laboratory Investigation and Response Network (Vet-LIRN) enables analyses of animal diagnostic samples and animal food/drug products. Through Vet-LIRN, the FDA leverages the expertise of a national network of veterinary diagnostic laboratories to provide additional capability and capacity to strengthen the overall national food safety system. The Ohio Animal Disease Diagnostic Laboratory (ADDL) will offer its expertise and services to support testing and surveillance projects under direction from Vet-LIRN, provide surge capacities for testing using standardized Vet-LIRN methods, and assist Vet-LIRN with emergency response testing.

PI_NAMEs: PRARAT, MELANIE  (contact)

PROJECT_TITLE: FDA Vet-LIRN Infrastructure Support for Ohio ADDL


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: BROOKINGS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: SOUTH DAKOTA STATE UNIVERSITY

ORG_STATE: SD

PHR: 4/12/23 Project Narrative The South Dakota Animal Disease Research and Diagnos�c Laboratory (SD ADRDL) will serve as a Whole Genome Sequencing (WGS) core laboratory for the Veterinary Laboratory Inves�ga�on and Response Network (Vet-LIRN). Working with 5 partner source labs, SD ADRDL will perform WGS analysis on Salmonella enterica, Escherichia coli, Staphylococcus pseudintermedius, and other relevant organisms, uploading to NCBI bioprojects designated by Vet-LIRN Program Oﬃce. This data will be used to surveil for genes important to an�microbial resistance. 5U18FD006558 Page 1 of 1

PI_NAMEs: RUESCH, LAURA  (contact)

PROJECT_TITLE: ADRDL Diagnostic testing support for the FDA CVM VET-LIRN program


PHR: Project Narrative: Through a collaboration with the FDA’s Veterinary Laboratory Investigation and Response Network (Vet-LIRN), the Louisiana Animal Disease Diagnostic Laboratory will work toward the common mission of promoting human and animal health by expanding our diagnostic capabilities and capacity for routine and emergency response. The continued support of laboratories in this network is crucial for strengthening national food safety by providing rapid detection and response in a large-scale outbreak or emergency event.

PROJECT_TITLE: CVM VetLIRN Veterinary Dagnostic Laboratory Program (U18)


ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Testing for antimicrobial resistance in sick animals is needed to support the mission of FDA to protect public health. In 2017, FDA Vet-LIRN launched a surveillance initiative including whole genome sequencing as a key component for mitigating the lack of standardization in antibiotic susceptibility testing in their network. Sequencing methods are now standardized across six laboratories in the network, including at Cornell, and we are requesting support for these activities for the next five years.

PI_NAMEs: GOODMAN, LAURA BRUNENGRABER (contact)

PROGRAM_OFFICER_NAME: MILLER, MEGAN

PROJECT_TITLE: Genomic surveillance for antimicrobial resistance in animals


PHR: FDA CVM Vet-LIRN PROGRAM PROPOSAL  FOR FOA PAR-23-202 “FDA Vet-LIRN Network Capacity-Building Project and Equipment Grants” NARRATIVE This Veterinary Laboratory Investigation and Response Network (Vet-LIRN) capacity building project strengthens the capacity, collaboration, and integration of food-safety laboratories and networks, thereby facilitating an effective and coordinated response to future human and animal food safety issues. The Vet-LIRN at the U.S. Food and Drug Administration (FDA) and Animal Diseases Diagnostic Laboratory at the Ohio Department of Agriculture (Ohio ADDL) will collaborate to perform whole genome sequencing (WGS) of foodborne pathogen isolates. This project will support the identification and adoption of emerging technologies and the harmonization of analytical methods used by equipment platforms for antimicrobial resistance (AMR) studies.

PROJECT_TITLE: FDA Vet-LIRN Cooperative Agreement with Ohio ADDL to support projects and work associated with One Health, animal food issues, antimicrobial resistance, and surge capacity testing.


PHR: Project Narrative This goal of this application is to enhance the veterinary diagnostic capacity and capabilities of Animal Disease Research and Diagnostic Laboratory (ADRDL), South Dakota in support of improving the national food safety system. This project will allow ADRDL to participate in Veterinary Laboratory Investigation and Response Network (Vet-LIRN). Through this program, ADRDL will serve as a regional sequencing lab and also will perform diagnostic testing as required by Vet-LIRN.

PROJECT_TITLE: Strengthening national food safety system by improving veterinary diagnostics


ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative: Antimicrobial resistance (AMR) monitoring is a critical function for veterinary diagnostic laboratories to aid in identification of new or emerging resistance, to identify potential resistance reservoirs, and assess efficacy of interventions to reduce resistance development. Not only do resistant bacterial infections impact animal health and welfare, but they also have significant potential for causing negative human health consequences through transmission of resistant bacteria or resistance genes through food or animal contact. Whole genome sequence AMR data form important veterinary bacterial pathogens and improvements in standardized data quality assurance/quality control for bacterial resistance detection increases the ability of FDA Center for Veterinary Medicine to accurately detect resistance and provide more accurate monitoring of antimicrobial resistance in veterinary species.

PI_NAMEs: BURBICK, CLAIRE R (contact)

PROJECT_TITLE: Antimicrobial Resistance Monitoring of Bacterial Pathogens of Veterinary Concern