ORG_CITY: Durham

ORG_NAME: REDBUD LABS, INC.

ORG_STATE: NC

PHR: NARRATIVE In this project, Redbud Labs will develop a compact, flexible solution for automated library preparation. Our goal is to enable decentralized sequencing by simplifying the workflow for small labs, both research and clinical.

PI_NAMEs: FISHER, JAY KENNETH (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Adoption;Automation;Bioinformatics;biothreat;Chemistry;Clinical;cloud based;Collection;commercialization;Communicable Diseases;Computer software;Containment;cost;Data;Decentralization;design;Development;Devices;Diagnostic;Diagnostic Equipment;diagnostic platform;Diagnostic tests;Disease;Disease Outbreaks;Disease Surveillance;Environment;Evolution;flexibility;Future;genomic epidemiology;Goals;High-Throughput Nucleotide Sequencing;Hour;improved;Incubated;innovation;instrument;Intervention;invention;laptop;Libraries;Library Automation;Ligation;Liquid substance;magnetic beads;Manuals;Marketing;Metagenomics;meter;Microfluidics;Military Personnel;Names;nanopore;next generation sequencing;Nucleic Acids;operation;pandemic disease;Pathogen detection;Performance;Phase;portability;Preparation;prototype;Public Health;repaired;Research;Research Personnel;Resource-limited setting;response;Risk;Sampling;Scientist;Signal Transduction;Small Business Innovation Research Grant;Specialist;success;System;Technology;testing access;Time;tool;Training;transmission process;Validation;Variant;Virus

PROJECT_TITLE: System for unitary automation of library preparation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-S (13)]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PHR: NARRATIVE In this project Redbud Labs will automate nucleic acid extraction from formalin-fixed paraffin-embedded (FFPE) tissue. Our system is compact, cost-effective, and easy-to- use. This Phase II project will seek to maximize the integrity and yield of NAs extracted from these samples.

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Acids;Automation;base;Biopsy;Centrifugation;Chemistry;Clinical;Colorectal Neoplasms;commercial launch;Consumption;cost effective;Cytolysis;Data;Decision Making;design;Development;Filtration;Formalin;Freezing;Future;Genomics;Goals;improved;instrument;Liquid substance;Lung Neoplasms;magnetic beads;Manuals;Marketing;Melanoma Tumor;meter;Methods;Microfluidics;Morphology;next generation sequencing;nucleic acid purification;Nucleic Acids;operation;Paraffin;Paraffin Embedding;Performance;Phase;Plasma;precision medicine;Preparation;preservation;Process;Protocols documentation;prototype;repository;Reproducibility;Resources;Risk;RNA;sample fixation;Sampling;skills;Small Business Innovation Research Grant;Solid;success;Swab;System;Therapeutic;Time;Tissue Embedding;tissue processing;Tissue Sample;Tissues;Translations;Tube;tumor;Validation;Waxes;Work

PROJECT_TITLE: Improving extraction success of FFPE samples with automated and reliable microfluidic sample preparation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-S (12)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Eye Disease and Disorders of Vision;Pediatric

ORG_CITY: SOMERVILLE

ORG_NAME: DIOPTER TECHNOLOGIES, INC.

ORG_STATE: MA

PHR: Cystinosis is a genetic disease characterized by accumulation of cystine crystals in multiple organs including cornea. The current treatment regimen is 8 drops of cysteamine every day, which is effective, but tedious and could lead to poor compliance. Our goal is to replace the 8xdaily drop treatment with a daily disposable contact lens which will provide similar delivery to the drops but improve compliance and address other deficiencies of the current formulation including side effects due to preservatives and acidic pH of the formulation.

PI_NAMEs: ADAMS, CHRIS  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 10 year old;Address;Age;Animals;base;Benzalkonium Chloride;Blurred vision;Cadaver;Clinical Research;Contact Lenses;Cornea;corneal scar;Cystamine;Cysteamine;Cysteine;Cystine;Cystinosis;Data;design;Diameter;Diffusion;dimer;Disease;Disulfides;Dose;Drops;Drug Kinetics;drug release profile;Endothelium;Ethanol;Exposure to;Eye;Eyedrops;Formulation;Freezing;Genes;Genetic Diseases;Glass;Goals;Hour;improved;In Vitro;in vivo;in vivo evaluation;Kidney;Legal patent;lens;Life;Lysosomes;manufacture;Measures;Metabolic Diseases;Molecular Weight;Mutation;Oral;Organ;Oryctolagus cuniculus;oxidation;Oxygen;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;Phase;Phosphate Buffer;Photophobia;potency testing;pre-Investigational New Drug meeting;Reaction;Redness;Regimen;Research;Saline;Shapes;side effect;Sterility;success;Symptoms;Technology;Testing;Therapeutic Effect;Tissues;Toxic effect;Treatment Protocols;Vial device;Vision;Vitamin E;Water

PROJECT_TITLE: Sustained cysteamine delivery by nanobarrier contact lenses to replace 8xdaily drops with a daily disposable lens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-M (12)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Human Genome;Neurosciences

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative: The role of maternal care in offspring health is widely accepted, but recent research has shown that paternal care contributes unique advantages to offspring, including significant impacts on survival and psychological development. Our research will fill a critical gap in the literature by providing novel insight into the genetic and neural basis of evolved variation in paternal care behavior in natural populations. This work will contribute to our understanding of the biology of paternal care in a vertebrate system and may reveal insights into the mechanistic basis of variation in this complex behavioral trait in humans.

PI_NAMEs: MORAN, RACHEL  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TITLE: Genetic and neural mechanisms of paternal care behavior

STUDY_SECTION: MRAF

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: BERKELEY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The nuclear envelope (NE) and the nuclear pore complex (NPC) embedded within the NE are vital structures for eukaryotic cells, and mutations in genes encoding NE and NPC components are intimately linked with a series of human diseases that are collectively known as nuclear envelopathies. However, our knowledge of the category and diverse functions of NE proteins in eukaryotic kingdoms, especially beyond humans and yeasts, remains limited. This research aims to comprehensively unravel the NE protein inventory in the eukaryotic life domain and explore novel, yet critical and conserved, roles of the NPC in facilitating rapid mitotic progression in undifferentiated cells and regulating gene expression via gene gating mechanism, which may offer key insights into fundamental cell biology and potential therapeutic avenues and impact fields ranging from genetics to medicine.

PI_NAMEs: GU, YANGNAN  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Bioinformatics;Biological;biological systems;Biomedical Engineering;Categories;Cell division;Cell Nucleus;Cell Physiology;Cell Proliferation;Cells;Cellular biology;Chromatin;Complex;env Gene Products;Equipment and supply inventories;Eukaryotic Cell;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic manipulation;Human;human disease;insight;Knowledge;Laboratories;Life;Link;Malignant Neoplasms;Medicine;Membrane;Mitotic;model organism;Molecular;Mutation;novel;Nuclear;Nuclear Envelope;Nuclear Pore Complex;nucleocytoplasmic transport;Plant Stems;Plants;Play;Process;Proteins;Proteomics;Regulation;Research;response;Role;Series;Signal Transduction;Stress;Structure;Therapeutic;Therapeutic Intervention;transcriptional reprogramming;Undifferentiated;Yeasts

PROJECT_TITLE: Understanding the role of the nuclear pore complex in undifferentiated cell proliferation and gene gating

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biotechnology;Brain Disorders;Gene Therapy;Genetics;Neurosciences;Substance Misuse

ORG_CITY: BELLEFONTE

ORG_NAME: ACTUATED MEDICAL, INC.

ORG_STATE: PA

PHR: Project Narrative: Alcohol addiction is a major public health burden. DREADDs (designer receptors exclusively activated by designer drugs) are chemogenetic tools primarily used for neuroscience research, but recently appreciated for their potential as therapeutics for neurological disorders, including addictive behaviors like alcohol addiction. A complication of the implementation of chemogenetic tools is that the viral vectors used to deliver them, such as an adeno-associated virus (AAV), must be reliably and accurately placed within target brain structures for precise viral expression and resultant clinical effect from the DREADDs. This project develops a system that leverages oscillation of a thin injection cannula for reduced insertion and friction forces relative to larger standard cannulas, improving the targeting and reliability of precise injections to deep brain locations.

PI_NAMEs: BAGWELL, ROGER BROOKS (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: addiction;Addictive Behavior;Adoption;Alcohol dependence;alcoholism therapy;Aliquot;Animal Model;Attention;behavior measurement;Behavior Therapy;Behavioral;Blood Vessels;Bolus Infusion;Brain;Brain region;brain tissue;Cannulas;cell type;Cells;Central Nervous System;Clinical;clinical effect;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;commercialization;Communities;Complication;Consumption;Counseling;Coupling;delivery vehicle;Dependovirus;designer receptors exclusively activated by designer drugs;Development;Devices;Disease;Distal;Dura Mater;Electronics;Electrophysiology (science);experience;experimental study;Failure;Family suidae;first-in-human;fluorophore;Frequencies;Friction;Future;gene editing technology;gene therapy;Genes;Genetic;Goals;Health;Health Sciences;Histologic;improved;in vivo;indexing;Infection;Infusion procedures;Injections;innovation;Intervention;Length;Liquid substance;liver function;Location;Manuals;Marketing;Medical;meetings;Mental disorders;meter;Methods;minimally invasive;Naltrexone;Needles;Nervous System Disorder;neural;neural circuit;Neurosciences;Neurosciences Research;Neurosurgeon;Operative Surgical Procedures;Oregon;Parkinson Disease;Penetration;Pennsylvania;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;Phase;Plasmids;Polydipsia;Population;Positioning Attribute;pre-clinical;Pre-Clinical Model;Primates;psychologic;Public Health;Puncture procedure;putamen;Radium;Recombinant adeno-associated virus (rAAV);Relapse;Renal function;Reporter;Research;Safety;Sales;Saline;Schedule;Science;Sepharose;Services;Small Business Innovation Research Grant;small molecule;Specificity;Stainless Steel;Stains;Standardization;Stimulus;Structure;Substance abuse problem;Syringes;System;Task Performances;Testing;Therapeutic;Thinness;Time;tool;Training;transgene expression;transmission process;Tropism;Uncertainty;Universities;usability;Validation;vector;verification and validation;vibration;Viral;Viral Vector;Withdrawal

PROJECT_TITLE: Oscillated Insertion Tool for Minimally Invasive, Low-Damage, Accurate Placement of Delivery Cannula to Improve Efficacy for DREADDS Therapy in Alcohol Addiction Treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-H (13)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Vector-Borne Diseases

ORG_CITY: Baltimore

ORG_NAME: VECTECH, LLC

ORG_STATE: MD

PHR: Project Narrative. The proposed project aims to develop a commercially available image recognition platform for operational larval surveillance of medically relevant mosquito species, initially capable of identification of 10 key species to Placer County, CA as initial proof of concept. The project will involve validating optics for larval species identification and modifying an existing imaging device to achieve these requirements, building a high-quality image dataset with the device, and training a computer vision system to identify mosquito larvae species. This tool will enable mosquito control organizations to make same-day control decisions based on larval surveillance data targeted to species of concern, leapfrogging conventional larval surveillance practices, and providing accurate and timely data on mosquito populations and potential disease transmission.

PI_NAMEs: FAIMAN, ROY  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Adult;Aircraft;Algorithms;Area;artificial intelligence algorithm;Bite;Breeding;Classification;Collaborations;Collection;commercialization;Computer Vision Systems;convolutional neural network;cost;County;crowdsourcing;Culicidae;Data;Data Set;Databases;Decision Making;design;Development;Devices;Diagnostic;digital;Disease;disease transmission;Disease Vectors;Environment;Goals;high resolution imaging;Image;Imaging Device;imaging platform;imaging system;Individual;Intervention;Larva;Measurement;Medical;Medical Surveillance;Microscope;mobile application;Modernization;Monitor;Morphology;Mosquito Control;Mosquito-borne infectious disease;Nature;Neural Network Simulation;operation;Optics;Persons;Phase;Population;Prevention;Process;remote sensing;Research;Resolution;Resources;sample collection;Site;Slide;Spatial Distribution;Specimen;Specimen Handling;Standardization;success;surveillance data;Surveillance Methods;Surveys;System;Systems Development;Testing;Ticks;tool;Training;Translating;Travel;unnecessary treatment;Vaccines;Validation;vector;vector control;Visual;wasting;Work

PROJECT_TITLE: Automated identification of larval mosquito species with computer vision


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: GERMANTOWN

ORG_NAME: VERACHEM, LLC

PHR: Project narrative Metalloenzymes have been identified as drug targets in virtually every therapeutic area, including anti-inflammatory, antibiotics, antivirals, and anticancer, but the complicated nature of metal interactions with potential drug molecules makes the already difficult drug development process even harder for this class of targets. This project aims to develop a software tool that can accurately predict the binding affinities of metalloenzymes and potential drug molecules, and therefore help research scientists more quickly discover drug candidates suitable for preclinical testing and beyond. Currently available molecular modeling methods are unable to make accurate enough predictions to help scientists with the design of metalloenzyme-targeting drugs; therefore, the proposed project will provide a new capability with significant impact on the development of treatments for human disease.

PI_NAMEs: WEBB, SIMON  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Acceleration;Active Sites;Affinity;Algorithms;anti-cancer;Anti-Inflammatory Agents;Anti-viral Agents;Antibiotics;Antineoplastic Agents;Area;Binding;Charge;Complex;computer cluster;Computer software;Consumption;Crystallography;density;design;Docking;drug candidate;Drug Design;drug development;Drug Industry;Drug Kinetics;Drug Targeting;drug-like compound;electronic structure;Environment;Enzymes;Exhibits;experimental study;Face;FDA approved;Free Energy;Generations;Geometry;human disease;improved;inhibitor;Ions;Ligand Binding;Ligands;metalloenzyme;Metalloproteins;Metals;Methodology;Methods;Mining;Modeling;Molecular Conformation;molecular modeling;Nature;neglect;novel;Output;oxidation;parallelization;perturbation theory;Pharmaceutical Preparations;Phase;Potential Energy;Preclinical Testing;predictive modeling;Preparation;Process;Program Development;Property;Proteins;quantum chemistry;Quantum Mechanics;Reproduction;Research;research and development;Resources;Scientist;Scoring Method;Series;Small Business Innovation Research Grant;small molecule libraries;Software Tools;Speed;Statistical Mechanics;Structure;System;theories;Therapeutic;therapeutic target;therapy development;Time;United States;Viral Cancer;virtual

PROJECT_TITLE: Metalloenzyme binding affinity prediction with VM2


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Kidney Disease;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: PEWEE VALLEY

ORG_NAME: LAGRANGE SCIENTIFIC, LLC

ORG_STATE: KY

PHR: PROJECT NARRATIVE  The aggressive and unpredictable nature of metastatic clear cell renal cell carcinoma (ccRCC) is reflected by high rates of morbidity and mortality. While drastic improvements to post-surgical surveillance protocols have been made over recent years, early identification of progression from primary tumor to a disseminated metastatic disease state remains a difficult challenge for physicians and frequently results in detrimental delays of therapeutic intervention. LAGRANGE SCIENTIFIC is developing an innovative technology that accurately and specifically identifies which patients at the time of primary tumor resection will experience a disseminated ccRCC metastasis, and with Phase II support, will mature this highly accurate prognostic test for later progression to metastasis into a regulatory-approved laboratory testing service.

PI_NAMEs: COUGHLIN, RICHARD THOMAS (contact)

PROGRAM_OFFICER_NAME: LOU, XING-JIAN

PROJECT_TERMS: Address;Alberta province;algorithm development;Algorithms;American;analytical method;anti-cancer research;biobank;Biological Assay;Biological Markers;biomarker panel;Cancerous;case control;Case/Control Studies;Characteristics;Chemicals;chemotherapeutic agent;Clear cell renal cell carcinoma;CLIA certified;Clinical;clinical diagnosis;cohort;Collection;commercialization;Cooperative Human Tissue Network;Core Biopsy;Data;Data Analyses;Databases;detection limit;Diagnosis;Diagnostic;diagnostic biomarker;diagnostic development;Diagnostic tests;Disease;Disease Progression;Early identification;Early treatment;Evaluation;Excision;experience;Feasibility Studies;Florida;follow-up;Goals;Health;Heterogeneity;high risk;Histopathology;Immunomodulators;improved;Individual;innovative technologies;Kidney Neoplasms;Label;Laboratories;Lead;Legal patent;liquid chromatography mass spectrometry;Malignant Neoplasms;Marketing;medical schools;metabolic abnormality assessment;metabolomics;Methanol;Methods;Morbidity - disease rate;mortality;multidisciplinary;multiple reaction monitoring;Nature;Neoplasm Metastasis;Ontario;Operative Surgical Procedures;Pathologist;Pathology;Patients;Performance;Phase;phase 2 study;Physicians;Pilot Projects;predictive marker;predictive panel;Primary Neoplasm;prognostic;prognostic assays;Prognostic Marker;programs;prospective;Protocols documentation;prototype;quality assurance;Receiver Operating Characteristics;Recurrence;Renal Carcinoma;research and development;Risk;Running;sample collection;Sampling;Services;Shipping;Small Business Innovation Research Grant;Source;Specificity;Specimen;standard of care;Surgical Oncologist;Survival Rate;Systemic Therapy;Techniques;Technology;Testing;testing services;Texas;Therapeutic Intervention;Time;Tissue Banks;Tissue Sample;Tissues;Training;Translating;tumor;Tumor Bank;tumor heterogeneity;Tumor stage;Tumor Tissue;United States National Institutes of Health;Universities;Update;validation studies;Virginia

PROJECT_TITLE: A PROGNOSTIC ASSAY FOR METASTATIC CLEAR CELL RENAL CELL CARCINOMA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-V (13)]


ADMINISTERING_IC: OH

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: ROCHESTER

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Proposal Narrative As a strategy combining health protection with health promotion to prevent worker injury and advance well- being, the broadened scope of Total Worker Health (TWH®) makes it a promising holistic approach to address the sign production, situation, and individual factors associated with sign language interpreter injury development. The overall objective of this study will employ implementation strategies to adapt and evaluate an integrated TWH® program and pilot test its efficacy on interpreter well-being. These project aims align with objective six of the National Occupational Research Agenda, Healthy Work Design and Well-Being Cross- Sector Program, “improve the safety, health, and well-being of workers through healthier work design and better organizational practices.”

PI_NAMEs: ROMAN, GRETCHEN  (contact)

PROJECT_TITLE: Health protection and promotion of sign language interpreters through implementation of Total Worker Health?

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Data Science;Diabetes;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Wound Healing and Care

ORG_CITY: Johns Creek

ORG_NAME: ANXOMICS LLC

ORG_STATE: GA

PHR: Project Narrative: The study aims to develop an image-based platform to manage and improve the outcomes of Diabetic Foot Ulcers (DFUs) by performing an automated image analysis of complications associated with impaired healing. The platform will analyze the phenotypic features of the DFUs using artificial intelligence to predict ulcers with a high probability of infection and ischemia along with changes in physical parameters such as color, size, and texture to assist physicians and patients in better managing DFUs.

PI_NAMEs: BHASIN, MANOJ  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Algorithms;Amputation;Antibiotic Resistance;Artificial Intelligence;automated image analysis;Caregivers;Caring;Cellular Phone;Characteristics;Chronic;Clinical;Color;Communicable Diseases;convolutional neural network;cost;cost effective;Data;Data Set;deep learning;deep learning algorithm;deep learning model;deep neural network;Detection;Development;diabetes management;Diabetes Mellitus;Diabetic Foot;Diabetic Foot Ulcer;Diagnosis;diagnostic platform;Evaluation;experience;Fibroblasts;healing;high risk;Home;Hospitals;Image;Image Analysis;Impaired healing;Impaired wound healing;improved;improved outcome;India;Infection;Inflammation;Information Management;International;Ischemia;Lighting;limb amputation;Marketing;Measures;Melatonin;Methods;Minor;Minority;Minority Groups;Mission;mobile application;Modeling;Molecular;Monitor;Nature;non-healing wounds;Normal tissue morphology;Outcome;outcome prediction;pathogen;Patients;Performance;Persons;Phase;Phenotype;Physicians;Pilot Projects;portability;predictive modeling;Principal Investigator;Probability;Prognosis;prospective;Quality Control;randomized, clinical trials;Remote management;segregation;Shapes;Signs and Symptoms;single-cell RNA sequencing;skills;Skin;Small Business Technology Transfer Research;Societies;System;Systems Analysis;Teaching Hospitals;Technology;Testing;Texture;Time;tool;Training;Translating;Ulcer;Underrepresented Minority;University Hospitals;user-friendly;Validation;Visual;Work;working group;wound;wound healing;Wound Infection;wound treatment

PROJECT_TITLE: A Deep Learning-based Platform for the Remote Management andAnalysis of Diabetic Foot Ulcers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-S (11)]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Pediatric;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Despite the demonstrated effectiveness of family-centered preventive interventions (FCPI) to prevent cardiovascular disease (CVD) risk factors during childhood, implementation barriers have led to their limited adoption in pediatric primary care. Two randomized effectiveness-implementation trials of the Family Check-Up 4 Health program conducted in several primary care systems have demonstrated significant positive effects on child and family health behaviors associated with CVD risk and have identified barriers to multiple implementation outcomes limiting scale-up and public health impact. Multiple implementation strategies developed in partnership with a standing Community Advisory Board will be integrated and tested in the proposed biphasic study to assess their effects on identified implementation barriers, with the goal of promoting widespread adoption and sustained implementation of family-based CVD prevention in primary care.

PI_NAMEs: BERKEL, CADY  (contact);SMITH, JUSTIN D

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: 13 year old;5 year old;Address;Adolescence;Adoption;Affect;Age;aged;Area;automated text message;Behavior Therapy;behavioral health;budget impact;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;care systems;Caring;Characteristics;checkup examination;Child;Child Health;Child Rearing;Childhood;Clinical;clinical decision support;Clinical effectiveness;Code;Collaborations;Communities;community advisory board;cost;Cost Analysis;cost effectiveness;Data;Development;disease disparity;economic cost;economic impact;Educational Curriculum;effective intervention;Effectiveness;effectiveness evaluation;effectiveness-implementation randomized trial;effectiveness/implementation hybrid;effectiveness/implementation study;Electronic Health Record;Emotional;Enrollment;Ethnic Origin;Ethnic Population;evidence base;Family;Family Demographies;Family health status;follow-up;Gender;Goals;Health;Health behavior;Health behavior and outcomes;Health Promotion;Home;Hybrids;implementation barriers;implementation cost;implementation design;implementation outcomes;implementation strategy;implementation/effectiveness;improved;Individual;individualized medicine;Informal Social Control;Integrated Health Care Systems;interest;Intervention;Link;Low Income Population;lower income families;Machine Learning;Mexican Americans;Modeling;Monitor;Motivation;motivational enhancement therapy;Outcome;Parents;Patients;pediatrician;Phase;Population;practice setting;prevent;Prevention trial;preventive intervention;Primary Care;primary care setting;primary care visit;primary outcome;Process;programs;prospective;Public Health;Race;racial population;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research Support;Resources;Risk;Risk Factors;Role;Sample Size;Sampling;scale up;skills;social;social health determinants;Suggestion;Supervision;support tools;System;Technology;Testing;Text Messaging;Time;Training;Translating;treatment as usual;treatment planning;Trust;United States Preventative Services Task Force;universal prevention;usability

PROJECT_TITLE: Testing Technology-Based Implementation Strategies for a Family-Based Pediatric Health Behavior Intervention in Community-Based Primary Care: A Cluster Randomized Factorial Trial

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(MA)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The causal role of aging on Alzheimer's disease (AD) risk variants in neuronal or glial cells is unresolved. We propose a team science approach to integrate computational and experimental models of aging, towards deconvolving the gene x environment impact of aging on gene expression, cellular aging phenotypes, and genetic risk for AD. We hope to find insights into the mechanism of disease initiation and progression in AD, in order to one day reverse the disrupted molecular pathways that contribute to this debilitating disorder.

PI_NAMEs: BRENNAND, KRISTEN JENNIFER (contact);GERSTEIN, MARK BENDER

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Affect;Age;age acceleration;age effect;age related;age related neurodegeneration;aged;Aging;aging brain;aging process;aging related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Automobile Driving;Back;Benchmarking;Binding;Biological Assay;Brain;brain cell;brain control;causal variant;Cell Aging;cell type;Cells;Chromatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Code;combinatorial;Computer Models;Data;Data Set;Dementia;Disease;Disease Progression;disorder control;disorder risk;drivers of aging;effective therapy;Embryo;Environment;Epigenetic Process;epigenetic regulation;epigenomics;Etiology;Exhibits;Experimental Models;Family;functional genomics;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic;Genetic Research;Genetic Risk;Genetic Screening;Genetic study;genetic variant;Genomics;Genotype;Genotype-Tissue Expression Project;hallmarks of aging;Health Care Costs;Heritability;Human;human induced pluripotent stem cells;Impaired cognition;In Vitro;in vitro Model;Individual;insight;Intervention;Life;Link;machine learning model;Measures;Methods;Microglia;Modeling;Molecular;Molecular Profiling;multimodality;multiple datasets;Mutation;network models;Network-based;neural;neural network;Neuroglia;Neurons;normal aging;novel;novel therapeutics;Pathogenesis;Pathologic;Pathway interactions;patient stratification;Patients;Personal Satisfaction;Phase;Phenotype;prevent;Prevention strategy;Process;Regulation;Reporter;Research;Risk Factors;risk variant;Role;Science;screening;Signal Transduction;Silicon Dioxide;Somatic Cell;standard care;stem cell model;Symptoms;Testing;Therapeutic;trait;transcription factor;transcriptomics;Translational Research;treatment strategy;Twin Studies;Untranslated RNA;Variant;Work

PROJECT_TITLE: Team science approach to integrate machine-learning models and functional genomics to study aging in the context of Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-2 (M2)]


ORG_CITY: SEATTLE

ORG_NAME: HEALIONICS CORPORATION

ORG_STATE: WA

PHR: NARRATIVE Many kidney failure patients receiving hemodialysis rely on vascular access via an implanted prosthetic arteriovenous shunt graft. These grafts typically suffer from flow blockages and infections, requiring frequent interventions to restore function. The severity of these issues can be reduced through improved graft integration with the surrounding tissue by applying an outer layer of our novel porous biomaterial scaffold onto conventional grafts. Effectiveness has been demonstrated in preclinical and clinical studies and this project now aims at obtaining FDA clearance for market introduction. v0.9

PI_NAMEs: MARSHALL, ANDREW  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Address;Anastomosis - action;Animals;Area;Arteries;Arteriovenous fistula;arteriovenous graft;Artificial Implants;Award;Bacteria;bacterial resistance;bioscaffold;Blood;Blood Cells;Blood flow;Blood Vessels;Bypass;Cannulations;capsule;Catheters;Clinical;Clinical Research;Clinical Trials;Coagulation Process;Collaborations;commercial launch;commercialization;constriction;Coupled;design;Development;Devices;Dialysis patients;Effectiveness;Elements;Environment;Exhibits;Failure;functional restoration;Funding;Goals;Hemodialysis;hemodynamics;high risk;human data;Hyperplasia;Implant;improved;Infection;infection risk;innovation;Intervention;Investments;Kidney Failure;Legal patent;Maintenance;Marketing;Mechanics;Medical;Microbial Biofilms;Needles;novel;Outcome;Pathologic;Patients;Performance;Phase;Physiologic arteriovenous anastomosis;Porosity;pre-clinical;preclinical study;Preparation;Privatization;Process;Production;Prosthesis;Qualifying;Quality of life;Recurrence;Relaxation;Resistance to infection;response;Risk;Series;Severities;Sheep;Silicones;Skin;Small Business Innovation Research Grant;Stenosis;Stress;Surface;Testing;Thrombosis;Tissues;Tube;Validation;Vascularization;Veins;Venous

PROJECT_TITLE: Commercial and Regulatory Development of an Enhanced Performance Hemodialysis Access Graft

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (19)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: HOUSTON

ORG_NAME: IMAGEN BIOWORKS INC.

PHR: PROJECT NARRATIVE A method for isolating cells with interesting spatiotemporal properties from three-dimensional cultures can be a powerful technique to understand how genes determine cellular functions, identify novel drug targets, and engineer effective cellular therapeutics. However, existing cell isolation techniques cannot retrieve cells from three-dimensional cultures with single-cell precision. The authors plan to address this unmet need by developing a platform/workflow that can isolate individual cells from 3D cultures based on their spatial and temporal characteristics.

PI_NAMEs: LEE, JIHWAN ;ST-PIERRE, FRANCOIS  (contact)

PROJECT_TERMS: 3-Dimensional;Academia;Address;aspirate;Biological Assay;biological systems;Biomedical Engineering;Businesses;cancer infiltrating T cells;cell behavior;Cell Physiology;Cell Separation;Cell Therapy;Cells;Characteristics;Coculture Techniques;code development;college;commercialization;Communication;Detection;Devices;Directed Molecular Evolution;Disease;Dissociation;drug development;Engineering;Environment;Exhibits;experience;experimental study;Faculty;Fluorescence;fluorescence imaging;Fluorescence-Activated Cell Sorting;gene therapy;Genes;Genetic;Genetic study;Genetic Variation;Goals;Grant;Image;improved;Individual;Industry;Innovation Corps;insight;instrument;interest;Joints;Journals;Label;laser capture microdissection;Lead;Legal patent;Light;Lighting;Marketing;Medicine;member;Methods;Microscope;Microscopy;Molecular;Nature;new technology;new therapeutic target;Optical Methods;Optics;Organ;particle;Pattern;Performance;Phase;Phenotype;photoactivation;Photons;Physiological;Population;programs;Property;Protein Engineering;Proteins;Protocols documentation;Publications;Reagent;Reporting;Research;Resolution;Retrieval;Rice;Sampling;Science;screening;Services;software development;Sorting;spatiotemporal;Speed;spheroids;Stimulus;Structure;Surface;T cell infiltration;T-Lymphocyte;Techniques;Technology;three dimensional cell culture;three dimensional structure;Time;tissue fixing;tissue/cell culture;Tissues;transcriptomics;tumor;two photon microscopy;two-photon;Universities;Variant;Visualization;Work

PROJECT_TITLE: A versatile platform to isolate cells from three-dimensional samples after spatial and temporal profiling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-G (15)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

PHR: NARRATIVE In this project, Redbud Labs will develop a compact, easy to use solution for automated hepatitis C virus (HCV) point of care (POC) RNA viral load (VL) testing. Our goal is to enable greater community surveillance and treatment of chronic HCV infections in diverse clinical settings.

PROGRAM_OFFICER_NAME: DYALL, JULIE

PROJECT_TERMS: Affect;Anti-viral Agents;Antibodies;antibody test;assay development;Biological Assay;Blood;Caring;Chemistry;Chronic Hepatitis C;chronic infection;Clinical;Cold Chains;Communities;comorbidity;Comprehensive Health Care;Consumption;cost;cross reactivity;design;Detection;detection limit;Development;Devices;Diagnosis;Diagnostic;Diagnostic Sensitivity;Diagnostic Specificity;Diagnostic tests;Diffusion;Disease;Disease Surveillance;Dryness;Electricity;Excision;Exposure to;Failure;Fluorometry;follow-up;Freeze Drying;Genotype;global health;Goals;HCV screening;healthcare burden;Hepatitis B Virus;Hepatitis C;Hepatitis C Antibodies;Hepatitis C virus;High Prevalence;HIV;HIV-1;human error;improved;Individual;Infection;instrument;isothermal amplification;Kinetics;Laboratories;Letters;Liquid substance;magnetic beads;Marketing;Measurement;meter;Methods;Microfluidic Microchips;Microfluidics;Molecular;neglect;Nucleic Acid Amplification Tests;nucleic acid purification;Nucleic Acids;Oranges;Patients;Persons;Phase;Plasma Cells;point of care;point of care testing;Polymerase;Population;Populations at Risk;portability;Preparation;Protocols documentation;Public Health;Reagent;recombinase;Resolution;Resource-limited setting;Rest;RNA;Routine Diagnostic Tests;Running;Sampling;scale up;Specificity;Specimen;success;surveillance strategy;Suspensions;System;Systems Integration;Technology;Testing;testing access;Time;treatment strategy;Validation;viral detection;Viral Load result;Viremia;virus testing;Visit

PROJECT_TITLE: Rapid point-of-care molecular test for HCV VL

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-B (13)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: HAYWARD

ORG_NAME: PLANET BIOTECHNOLOGY, INC.

PHR: Gonorrhea is the second most common bacterial STI and affects over 87 million people annually, globally. The emergence of multidrug-resistant gonococcal strains worldwide has severely limited treatment options. Safe and effective therapeutics against gonorrhea are urgently needed. Here, we will develop and evaluate complement-based therapeutics that provides broad protection against both PorB1A and PorB1B strains using a combination of our lead Fc3/FH* with FH6-7/Fc or C4BP/Fc.

PI_NAMEs: LEWIS, LISA ANN;SHAUGHNESSY, JUTAMAS ;WYCOFF, KEITH  (contact)

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: Affect;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Arthritis;bactericide;Binding;Biological Assay;Biotechnology;Ceftriaxone;Cells;Characteristics;Chimeric Proteins;Chlamydia;chronic pelvic pain;Classification;Clinical;Collaborations;Complement;complement 4b-binding protein;Complement Factor H;Complement Inactivators;Cytolysis;cytotoxicity;Dermatitis;design;Development;Devices;Drug-resistant Neisseria Gonorrhoeae;Ectopic Pregnancy;efficacy evaluation;efficacy testing;Endocarditis;Engineering;Epithelial Cells;fitness;Flow Cytometry;Freeze Drying;Goals;Gonorrhea;Health;HIV;Human;IgG3;Immune Evasion;Immunoglobulin G;Immunoglobulin M;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vitro testing;in vivo;Incidence;Infection;Infertility;inhibitor;Knowledge;Laboratories;Lead;Ligands;Mediating;Membrane Proteins;Modeling;mouse model;Multi-Drug Resistance;Mus;Neisseria gonorrhoeae;novel;Pathway interactions;Persons;Planets;Plants;Point Mutation;preclinical development;Prevalence;prevent;Prevention;Protein Binding Domain;Proteins;public health priorities;rational design;Recommendation;Reporting;Research Personnel;Resistance;Serum;Sexually Transmitted Diseases;Technology;Testing;Therapeutic;therapeutically effective;therapy development;Tobacco;Transgenic Mice;transmission process;trend;United States;Universities;Vaccines;Vagina;Vaginal Ring;VDAC1 gene;Virulence Factors;Woman;Work

PROJECT_TITLE: A broad spectrum anti-gonorrhea immunotherapeutic

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-X (14)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE: The architecture of the retina is established during development by the generation and maintenance of a balanced complement of retinal cell types, which can be disrupted in pathological situations, including retinal neurodegeneration. The role of immune cells, such as resident microglia, in the development and function of the retina is poorly understood. This study will investigate the molecular pathways governing the properties of developing retinal microglia, and how this influences development of the retina itself. THERE IS NO CHANGE FROM THE ORIGINAL SUBMISSION

PI_NAMEs: VETTER, MONICA L (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TITLE: Developmental regulation of retinal microglia


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Immunotherapy;Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: Tigard

ORG_NAME: VIROGENOMICS BIODEVELOPMENT, INC.

ORG_STATE: OR

PHR: Project Narrative There are currently no FDA-approved treatments for methamphetamine addiction. Our previous studies show that treatment with MHC Class II constructs can improve cognitive function, decrease drug-seeking behavior, and reduce inflammation following methamphetamine use in animal models. This proposal aims to move our current generation construct, DRhQ, from the lead optimization stage to the preclinical development stage by evaluating treatment efficacy and relevant biomarkers, which are critical steps in advancing the drug into the clinic.

PI_NAMEs: LOFTIS, JENNIFER M;MURNANE, KEVIN SEAN;SHIRLEY, RENEE LYNN (contact)

PROGRAM_OFFICER_NAME: KARUPPAGOUNDER, SARAVANAN SHANMUGAM

PROJECT_TERMS: Abstinence;addiction;Addictive Behavior;Address;Aftercare;Amphetamines;Animal Model;Animals;Area;Axon;Behavior;Behavior Therapy;Binding;Biological;Biological Markers;Brain;Brain region;C57BL/6 Mouse;Cells;Central Nervous System;Clinic;Clinical;Clinical Trials;Cognition;Cognitive;cognitive function;Collection;Corpus striatum structure;Cues;cytokine;Data;design;Disease;Disease remission;drug development;Drug Kinetics;drug seeking behavior;Drug usage;effectiveness evaluation;Evaluation;Excision;experimental study;FDA approved;Formulation;Generations;Health;healthy volunteer;Hippocampus;Human;Immunologic Factors;Immunotherapeutic agent;Immunotherapy;improved;Individual;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Intake;Knock-out;Laboratories;Lead;lead optimization;macrophage migration inhibitory factor receptor;manufacture;Marketing;Measurable;Methamphetamine;Methamphetamine dependence;methamphetamine exposure;methamphetamine use;MHC Class II Genes;Migration Inhibitory Factor;Modeling;monomer;mouse model;Multiple Sclerosis;Mus;Neuroimmune;neuroinflammation;neuron regeneration;Neurons;neurotoxic;novel therapeutic intervention;Patients;Pharmaceutical Preparations;pharmacodynamic biomarker;Phase;Phase I Clinical Trials;Phase II Clinical Trials;Plasma;Population;pre-clinical;preclinical development;preclinical efficacy;preclinical safety;preference;Prefrontal Cortex;Process;Production;protein expression;psychostimulant;Questionnaires;Rattus;receptor;Recombinant Proteins;Recording of previous events;Recovery;Relapse;relapse patients;remyelination;repaired;Research;research clinical testing;Rodent;Self Administration;Signal Transduction;Small Business Innovation Research Grant;Specimen;standard of care;Stimulant;stimulant use;stimulant use disorder;Substance Use Disorder;Surveys;Testing;Therapeutic;therapeutic target;Tissues;Toxicology;Translating;Treatment Effectiveness;Treatment Efficacy;treatment response;Wild Type Mouse

PROJECT_TITLE: Immunotherapeutic Targeting CD74 as a Treatment for Stimulant Use Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-S (14)]


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative  Intermittent exotropia, a periodic outwards deviation of the eyes, is a condition that affects millions of Americans. Treatment has been hindered by a lack of knowledge about its prognosis, inability to quantify its severity, and limited understanding of its neural mechanism. This research project will validate the use of ambulatory eye tracking glasses for measurement of exotropia occurrence rate and uncover the contribution of retinal ganglion cells projecting to a midbrain center controlling eye movements.

PI_NAMEs: HORTON, JONATHAN C (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Administrative Supplement;Affect;Amblyopia;Ambulatory Monitoring;American;animal data;area striata;awake;Axon;Brain Stem;Caring;Cells;Child;Childhood;Clinical;Consensus;Convergence Insufficiency;Data;Data Analyses;Dependovirus;Diplopia;Discrimination;Employment;Esthesia;Exotropia;experimental study;Eye;eye hand coordination;Eye Movements;follow-up;ganglion cell;Genes;Glass;Goals;Injections;insight;instrument;Knock-out;Knowledge;Label;Laboratory Study;Lateral Geniculate Body;Lentivirus Vector;light weight;Longitudinal, observational study;Macaca;Measurement;Measures;Midbrain structure;Monitor;Monkeys;monocular;Natural History;neural;neuromechanism;nonhuman primate;observational cohort study;Operative Surgical Procedures;patient stratification;Patients;Periodicals;Pharmaceutical Preparations;Positioning Attribute;Prejudice;prevent;Primates;Prognosis;Property;prospective;psychological distress;Publishing;Quality of life;receptive field;Recommendation;Research;Research Project Grants;response;Retina;Retinal Ganglion Cells;retinotectal;retrograde transport;Risk;Saccades;sample fixation;Scotoma;Severities;social;Strabismus;superior colliculus Corpora quadrigemina;System;Technology;tetanospasmin;Tetracyclines;Time;Toxin;Tracer;translational approach;United States;Update;Vision;Visual;Visual Fields;Visual impairment;visual tracking;wearable device


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: IOWA CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative: The proposed project evaluates the trends in non-nurse staff turnover, factors associated with turnover, and adverse implication of turnover on resident quality in Iowa nursing homes. It is relevant to public health because it will provide empirical evidence for state and national policymakers on ways to address staff turnover and improve worker and resident welfare.

PI_NAMEs: SHARMA, HARI  (contact)

PROJECT_TITLE: Improving the Well-being of Nursing Home Workers  An Examination of Non-nurse Staff Turnover and Quality in Nursing Homes


ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Features of employment precarity are associated with adverse behavioral health outcomes; however, most studies have not examined employment precarity comprehensively, nor have they explored increasing employment precarity and risk of poor behavioral health over time. The proposed project will provide a mechanism to measure employment precarity comprehensively while accounting for its dynamic nature over time and will elucidate the relationships between employment precarity, employment variability, and behavioral health longitudinally. Determining the relationships between these phenomena across the life course can help to identify opportunities for more targeted research to pinpoint possible interventions to prevent or reduce adverse behavioral health outcomes in the US workforce.

PI_NAMEs: BONNEY, TESSA  (contact)

PROJECT_TITLE: Employment Precarity and Adverse Behavioral Health Outcomes in the NLSY79 and 97 Cohorts


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: MADISON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This project investigates the impacts of drone-induced distractions on construction workers (i.e., material handling laborers and roofers) at heights. The relationships between the distraction impacts and the drone operations are quantified. The project will help to prevent fatal and non-fatal injuries related to falls, slips, and trips due to the distractions induced by emerging aerial robotics and automation technologies in construction.

PI_NAMEs: ZHU, ZHENHUA  (contact)

PROJECT_TITLE: Impacts of Drone Distractions on Working Safety at Heights in Construction


ED_INST_TYPE: SCHOOLS OF NURSING

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE The provision of nursing care often involves risk taking procedures that can result in injury to the provider. Yet, little is known about the unit-level prevalence of these injuries, the contributing factors and the associated costs. Understanding the mechanism of workplace injuries among acute care nurse can improve care delivery and nurse and patient outcomes.

PI_NAMEs: CIMIOTTI, JEANNIE P.;LI, YIN  (contact)

PROJECT_TITLE: Workplace Injuries among Acute Care Nurses: Implications for the Healthcare System


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative This pilot study will be the first thorough approach to consider the comprehensive ecosystem leading to highway struck-by hazards. The proposed approach makes use of combination of objective and subjective methods, to measure workers’ cognitive load relative to hazard recognition performance under various conditions and provide practical guideline for designing interventions that address a practical need, instead of fitting a technology to an issue. As such, this project is expected to provide important and impactful new knowledge that can help guide and facilitate industry implementation (e.g., when, how, and which emerging technologies to use “safely”).

PI_NAMEs: ROOFIGARI-ESFAHAN, NAZILA  (contact)

PROJECT_TITLE: Pilot Study to Investigate and evaluate Factors impacting Highway Construction Workers' Hazard Recognition Performance


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This project addresses a critical research gap specific to the U.S., wherein there have been no large, nationally representative, cohort studies of the association between long working hours and CVD mortality by applying a Research to Practice (r2p) approach in reducing the occupational mortality burden of CVD. The short- and long- term outputs and outcomes would be to create an active database of evidence on this association. This project has national and global relevance, and addresses goals set by the National Occupational Research Agenda (NORA) Health Work Design and Well-being sector and the NORA Cancer, Reproductive, Cardiovascular, and Other Chronic Disease Prevention cross-sectors.

PI_NAMEs: LI, JIAN  (contact)

PROJECT_TITLE: Do long working hours increase the risk of cardiovascular disease mortality? Evidence from the U.S. National Health Interview Survey 1997-2015


ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Narrative Although workers in the drying cleaning and laundry industry are exposed to synthetic fibers (containing microplastics) by handling clothing and linens every day, these workers’ exposure to microplastics is mainly unknown. Further, the effects of work-related factors (workforce, workplace, and work hazards) on exposure to microplastics among these workers are not investigated. This proposed R21 study, in response to the National Occupational Research Agenda: the Services Sector and the Cross-sector of Healthy Work Design, will provide helpful information for workers, industry, local, state, and national agencies, and policymakers to develop a mitigation strategy for reducing workers’ exposure to microplastics in this business sector.

PI_NAMEs: HAN, INKYU  (contact)

PROJECT_TITLE: Inhalation exposure assessment to microplastics for workers in the laundry and dry cleaning industry


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Neurosciences;Substance Misuse

ORG_CITY: CHARLESTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Alcohol abuse causes or exacerbates many diseases including neurological disease, and is a leading cause of preventable death in the United States. Much of the toxicity associated with ethanol, including metabolic dysfunction, is due to the production of its reactive metabolite acetaldehyde, which in the brain is produced primarily by the enzymes catalase and CYP2E1. In this proposal, we seek to understand how chronic binge drinking changes acetaldehyde production by CYP2E1 inside brain regions, and the consequences on cellular metabolism and stress.

PI_NAMEs: HARTMAN, JESSICA HELENE (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Acetaldehyde;Acute;Alcohol abuse;Alcohol consumption;Alcohol dehydrogenase;alcohol effect;alcohol exposure;alcohol use disorder;Alcohols;binge drinking;Brain;Brain region;Caenorhabditis elegans;Cardiovascular Diseases;catalase;Cell Line;Cells;Cerebellum;Chronic;chronic alcohol ingestion;Consumption;Cultured Cells;CYP2E1 gene;Disease;Economic Burden;Endoplasmic Reticulum;Enzymes;Ethanol;Ethanol Metabolism;Ethanol toxicity;experimental study;Exposure to;Fatty Liver;frontal lobe;Funding Opportunities;Gene Targeting;Genotype;Goals;Grant;Health;Heavy Drinking;Hippocampus;Human;innovation;insight;Intake;Link;Lipid Peroxidation;liver injury;Malignant Neoplasms;Measures;Mediating;Membrane;Metabolic;Metabolic dysfunction;Metabolism;Microsomes;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Mus;Myopathy;Nervous System Disorder;Nervous System Trauma;Neurosciences;Organ;Organelles;Osteoporosis;Outcome;Oxidative Stress;Oxidative Stress Induction;Pathology;Pathway interactions;peroxisome;Prefrontal Cortex;prevent;preventable death;Production;protein complex;Regulation;Research;Research Personnel;Resources;respiratory;Role;Specificity;Stress;subcellular targeting;System;Testing;Therapeutic;therapeutic target;Toxic effect;Transgenic Mice;Transgenic Model;Transgenic Organisms;United States;Work

PROJECT_TITLE: Subcellular-targeted CYP2E1 and alcohol in the brain

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project Narrative Membrane proteins regulate cellular processes through conformational changes across the plasma membrane, yet such transmembrane processes are often inaccessible with current tools. We will advance spectroscopic and biochemical methods and, through these advances, probe the membrane proteins relevant to treatments for cancer and antibiotic resistant infection. The proposed studies will introduce an approach to uncover the biophysical mechanisms of this important class of biomolecules.

PI_NAMEs: SCHLAU-COHEN, GABRIELA  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: antibiotic resistant infections;Bacteria;Behavior;Biochemical;Biophysical Process;Biophysics;Cancer Biology;cancer therapy;Cell membrane;Cell Physiology;Chemoreceptors;Complex;Drug Design;Drug Targeting;Environment;Epidermal Growth Factor;Fluorescence;improved;Individual;insight;interest;Investigation;Knowledge;Laboratories;Length;Ligands;Lipid Bilayers;Mammals;Membrane;Membrane Proteins;Methods;microbial;Molecular;Molecular Conformation;nanodisk;National Institute of General Medical Sciences;non-Native;Organism;Physiological;Plants;Process;protein structure;Proteins;Protocols documentation;receptor;Resolution;Role;Signal Transduction;single molecule;single-molecule FRET;Spectrum Analysis;Stimulus;sugar;Tars;temporal measurement;tool;Work

PROJECT_TITLE: Revealing transmembrane conformational signaling through single-molecule FRET

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative This grant will design and measure a novel stakeholder- and technology-based framework aimed at improving dementia screening and diagnosis, secondary cardiovascular preventive measures, and utilization of anticholinergics, in primary care settings, and among disadvantaged and racial and ethnic minority populations at risk for dementia. The study will be in the context of a pilot Embedded Pragmatic Clinical Trial (ePCT) that is optimized with/for the stakeholders (patients, caregivers, primary care providers) and leverages validated methods based on electronic health records, artificial intelligence, and modern clinical workflow integration. This pilot ePCT will pave way for larger ePCTs that address disparities in timely diagnosis, access to specialists, and evidence-based care delivery.

PI_NAMEs: BRODY, ABRAHAM AIZER;DODSON, JOHN A;RAZAVIAN, NARGES  (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Address;Adoption;Affect;age-related disease;Alzheimer's Disease;Alzheimer's disease related dementia;Ambulatory Care;Anti-Cholinergics;Artificial Intelligence;Asian Americans;Black race;burden of illness;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular risk factor;Cardiovascular system;care delivery;Caregiver support;Caregivers;Caring;Clinical;clinical decision support;Cognitive;cohort;Communities;Complex;Coupled;Dementia;dementia risk;design;Detection;Diabetes Mellitus;Diagnosis;Disadvantaged minority;Disease;Disparity;Early Diagnosis;economic disparity;effectiveness evaluation;Elderly;Electronic Health Record;Enrollment;ethnic minority population;Ethnic Population;Evaluation;evidence base;Failure;Family;Future;Goals;Grant;Health;health management;Health Status;High Prevalence;human old age (65+);Hypertension;Impaired cognition;implementation measures;improved;Individual;Inequity;Intervention;Latino;Lipids;Machine Learning;machine learning method;Measures;Medicaid;Memory;Methods;mild cognitive impairment;Modeling;Modernization;Monitor;Native American population;Neurologist;novel;novel therapeutics;Obesity;older adult;Outcome;Pathogenesis;patient engagement;Patient-Focused Outcomes;Patients;Persons;Population;Population Heterogeneity;Populations at Risk;Pragmatic clinical trial;pragmatic trial;Predictive Value;preventive intervention;Preventive measure;Primary Care;primary care provider;primary care setting;primary outcome;Qualifying;Race;racial diversity;racial minority population;Risk Factors;screening;screening disparities;screening program;secondary outcome;Secondary Prevention;Smoking;socioeconomic disadvantage;socioeconomics;Specialist;Strategic Planning;support tools;Technology;Testing;Therapeutic Agents;tool;treatment arm;Underrepresented Minority;Uninsured;United States;uptake;usability

PROJECT_TITLE: Leveraging Electronic Health Records for Reducing Dementia Screening Disparities in Diverse Communities

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Gene expression plays a central role in immune regulation and is often affected in immune diseases and during viral infections. The goal of the proposed research is to determine the rules governing the regulation of immune genes and to determine the mechanisms by which viruses hijack immune expression programs to favor viral replication. The findings and principles uncovered by these studies will lay a foundation for the design of novel therapeutic strategies.

PI_NAMEs: FUXMAN BASS, JUAN IGNACIO (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Affect;Binding;Biological;Biological Assay;Biological Process;Cell Proliferation;cell type;Cells;Cues;cytokine;Cytokine Gene;Data Set;design;Disease;DNA Viruses;Double Stranded DNA Virus;Foundations;Gene Expression;Gene Expression Profile;gene regulatory network;Genes;genetic manipulation;Genetic Transcription;Genome;genome-wide;Goals;Human;Hybrids;Immune;Immune Evasion;immune function;Immune response;Immune System Diseases;immunoregulation;Immunosuppression;Individual;Laboratories;Logic;Metabolic;Modeling;novel;novel therapeutic intervention;Outcome;pathogen;Play;Productivity;programs;Promoter Regions;protein protein interaction;Regulation;Regulatory Element;Reporter;Research;response;Retroviridae;Role;Specificity;Structure;Therapeutic;transcription factor;Transcriptional Regulation;Viral;Viral Genes;Viral Genome;Viral Physiology;Virus;Virus Diseases;Virus Latency;Virus Replication;Yeasts

PROJECT_TITLE: Structure and Function of Immune Gene Regulatory Networks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Cancer;Kidney Disease;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: Project Narrative The Children’s Oncology Group (COG) brings together more than 10,000 experts to refine front-line therapy for childhood cancer, study novel approaches to patients with recurrent disease, advance understanding of cancer biology, and improve supportive care and quality of life for cancer survivors. Dr. Jeffrey Dome has been a substantial contributor to the COG ever since its inception over 20 years ago at both the central and local levels. The NCI Research Specialist Award will provide a mechanism to protect his time to continue to advance COG science.

PI_NAMEs: DOME, JEFFREY S (contact)

PROGRAM_OFFICER_NAME: MAHER, MOLLY ELIZABETH

PROJECT_TERMS: Adolescent;Amendment;Award;Bilateral;Biology;Cancer Biology;Caring;Cessation of life;Child;Classification;clinical practice;clinical trial enrollment;Clinical Trials;Clinical Trials Cooperative Group;Collaborations;Conduct Clinical Trials;Country;Development;Diagnosis;Discipline;Disease;Enrollment;Fostering;Future;Generations;Histology;Hospitals;improved;Infrastructure;Institution;International;Kidney Neoplasms;Leadership;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant childhood renal neoplasm;Malignant Neoplasms;member;National Clinical Trials Network;Nephroblastoma;novel marker;novel strategies;operation;participant enrollment;Patients;Pediatric Oncology Group;Phase;Principal Investigator;protocol development;Publications;quality assurance;quality of life for cancer survivors;Recurrent disease;Research;Rhabdoid Tumor;Science;Site;Specialist;Support Groups;Supportive care;Therapeutic;Therapeutic Trials;Time;tumor DNA;United States

PROJECT_TITLE: Development, review, and conduct of Children's Oncology Group (COG) Clinical Trials


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Palliative Care;Parkinson's Disease;Rare Diseases;Rehabilitation

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: PROJECT NARRATIVE Anxiety symptoms are very common among people with neurodegenerative movement disorders, including Huntington’s disease (HD) and Parkinson’s disease (PD). These symptoms cause significant burden for patients and caregivers, and evidence-based treatments are lacking. This project includes development and preliminary evaluation of a novel, easily accessible, web-based psychological intervention (MindTrails- Movement) for treating anxiety in HD and PD.

PI_NAMEs: GIBSON, JESSIE SELLERS (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Address;Adult;American;Anxiety;Anxiety Disorders;anxiety reduction;anxiety symptoms;anxious;Behavior Therapy;Benign;Breathing;career;career development;Caregiver Burden;Caregivers;Case Series;Clinical;Clinical Trials;Clinical Trials Design;Cognition;Cognitive;Cognitive Therapy;cognitive training;Collaborations;Communities;cost;COVID-19 pandemic;Data;design;Development;Diagnosis;digital;Doctor of Philosophy;Environment;Evaluation;Evidence based treatment;experience;FDA approved;Feedback;flexibility;follow-up;Foundations;functional status;Gait abnormality;Goals;Home;human centered design;Huntington Disease;ideation;improved;improved outcome;Individual;innovative technologies;internet delivery;Intervention;Interview;Knowledge;Leadership;Measurement;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Modification;Mood Disorders;Movement;Movement Disorders;Nerve Degeneration;Neurodegenerative Disorders;neuropsychiatric symptom;Nonpharmacologic Therapy;novel;Nurses;Nursing Schools;off-label use;Online Systems;Parkinson Disease;Participant;Patient Recruitments;Patients;Persons;Pharmaceutical Preparations;Phase;Physical activity;Population;Prevalence;Process;programs;Protocols documentation;prototype;Provider;psychologic;Quality of life;Recommendation;recruit;Research;research and development;Research Personnel;Sampling;Scientist;self-reported anxiety;sex;skills;stakeholder perspectives;Strategic Planning;Subgroup;success;symptom management;symptom treatment;Symptoms;Testing;therapy development;Thinking;Time;Training;Training Programs;trait;Transportation;Universities;Virginia;Waiting Lists;Work

PROJECT_TITLE: Modification of Threat Interpretation Bias to Reduce Anxiety in Neurodegenerative Movement Disorders

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(84)]


ORG_CITY: NEW HAVEN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE We propose to develop a set of DNA-nanostructure-based tools for controlling membrane shape, tension and dynamics in a programmable way with high precision. This toolkit will create precisely controlled systems for the mechanistic studies of protein-mediated membrane trafficking and membrane-modulated protein functions and in the future, enable applications in biotechnology and synthetic biology such as drug delivery and artificial organelles.

PI_NAMEs: LIN, CHENXIANG  (contact)

PROJECT_TERMS: 3-Dimensional;Biochemical;Biophysics;Biotechnology;Cell-Free System;Cells;Cellular biology;chemical property;Chemicals;Complex;DNA;Drug Delivery Systems;Engineering;Future;Geometry;Knowledge;Lipid Bilayers;lipid transport;Lipids;Liposomes;mechanical properties;Mediating;Membrane;Membrane Proteins;membrane reconstitution;Methods;Modification;Molecular;molecular assembly/self assembly;Motion;nanodisk;nanoengineering;nanopore;Nanostructures;Nanotechnology;Nutrient;Organelles;physical property;Protein Conformation;protein function;Proteins;reconstitution;Research;Role;Shapes;Signal Transduction;structural biology;Structure;synthetic biology;System;tool;trafficking;uptake;Waste Management

PROJECT_TITLE: DNA nanotechnology enabled high-precision membrane engineering


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PONCE

ORG_NAME: PONCE SCHOOL OF MEDICINE

ORG_STATE: PR

PHR: NARRATIVE Hispanic cancer patients and survivors face social and structural inequalities perpetuating mental health disparities while no interventions exist to address these health inequities perpetrated by structural, social, and social-environmental adverse events. This project is innovative because it disrupts traditional psycho-oncology mental health care to address upstream structural (limited access to psycho-oncology mental health care and psychological distress screening), social (mental health stigma), and biological (psychological stress and inflammation biomarkers) determinants of mental health among Hispanic cancer patients and survivors. The team anticipates this project will push a transformative population-level impact through a multilevel approach that empowers communities to understand and address mental health among individuals.

PI_NAMEs: ARMAIZ-PENA, GUILLERMO N;CASTRO, EIDA MARIA (contact)

PROGRAM_OFFICER_NAME: DOOSE, MICHELLE

PROJECT_TERMS: Academia;Address;Adverse event;Anxiety;anxiety symptoms;Bankruptcy;Behavior;biobehavior;Biological;Biological Markers;Cancer Patient;Cancer Survivor;Caregiver support;Caring;Case Management;Catecholamines;chemokine;Chemoresistance;Chronic;Chronic stress;Clinical;Clinical Research;Clinical Trials;Communication;Communities;community empowerment;Community Health;Community Health Aides;community intervention;community led intervention;community partners;Community Services;COVID-19 pandemic;cytokine;Data Collection;depressive symptoms;Diagnosis;Disease Progression;Distress;Earthquakes;Economics;empowerment;Equity;Event;experience;Exposure to;Face;Family;Family Caregiver;Financial Hardship;geographic disparity;Government;Health;health care quality;health care service;health disparity;health inequalities;Health Personnel;Health Sciences;Health system;Healthcare Systems;High Prevalence;Hispanic;Hispanic Populations;Hurricane;Hydrocortisone;hypothalamic-pituitary-adrenal axis;implementation intervention;Individual;Inequality;Inequity;Inflammation;inflammatory marker;innovation;insight;Institute of Medicine (U.S.);Institution;Intervention;intervention effect;Job loss;Location;Malignant Neoplasms;Medical;member;Mental Depression;Mental disorders;Mental Health;Mental health promotion;Mental Health Services;migration;Natural Disasters;Not Hispanic or Latino;Oncology;Outcome;Personal Satisfaction;Phase;Physiological;Politics;Population;Poverty;prevent;Prevention;psychologic;psychological distress;Psychological Stress;psychosocial;Publishing;Puerto Rican;Puerto Rico;Recommendation;Reporting;Research;Research Personnel;Resources;Role;Rural;screening;Services;skills;social;social disparities;social factors;Social Justice;social stigma;socioenvironmental factor;Specialist;Stress;structural determinants;Survivors;systematic review;systemic inflammatory response;Training;underserved community;United States;Universities

PROJECT_TITLE: Mental Health CPR: Transforming Cancer Survivors' Mental Health with Community Participatory Reach for Equity


ADMINISTERING_IC: TR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The Colorado Clinical and Translational Sciences Institute’s (CCTSI) T32 Pre-Doctoral Training Program aligns and supports the goals of NCATS to ensure that a diverse pool of highly trained scientists is available in adequate numbers and in appropriate research areas to carry out the nation’s clinical and translational science research agenda. Our proposed Team Oriented Training across the Translational Sciences Spectrum (TOTTS) program will support pre-doctoral trainees’ (biomedical/bioengineering PhD students, population health/health outcomes PhD students, clinician doctoral students) competency development and foster characteristic development for translational research scientists. Evaluation will focus on our ability to achieve program objectives and goals of attracting and supporting the training and persistence in the field of individuals from diverse (especially underrepresented) backgrounds that have the potential to infuse clinical translational science and research with new perspectives and approaches that are efficient and effective.

PI_NAMEs: CICUTTO, LISA  (contact)

PROGRAM_OFFICER_NAME: DIBELLO, ANTHONY THOMAS

PROJECT_TERMS: Colorado;pre-doctoral;Universities

PROJECT_TITLE: CTSA Predoctoral T32 at University of Colorado Denver


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dissemination and Implementation Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE The proposed research is relevant to both public health and NIH’s mission because developing a smartphone app that rapidly delivers naloxone to opioid overdose victims may deescalate the overdose epidemic in Philadelphia and improve the health of the U.S. by understanding mental, addictive, and physical disorders.

PI_NAMEs: LANKENAU, STEPHEN E (contact);SCHWARTZ, DAVID GARY

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Acute;Address;Adoption;African American population;behavioral study;Cessation of life;Cities;Communities;community organizations;COVID-19 impact;COVID-19 pandemic;design;Disease;Effectiveness;Emergency Situation;Enrollment;Ensure;Environment;Epidemic;Equity;Event;experience;Family member;Feasibility Studies;Fentanyl;Goals;Government Agencies;Health;Heroin;improved;innovation;insight;Intervention;Latinx;Link;Local Government;Maintenance;manufacture;Medical;member;Mission;Modeling;mortality;Naloxone;naloxone dispensing;Neighborhoods;opioid epidemic;opioid misuse;opioid mortality;opioid overdose;opioid use;Outcome;Outcome Measure;Overdose;overdose death;Overdose reduction;Overdose reversal;overdose risk;Participant;Pathway interactions;Pattern;Persons;Philadelphia;pilot test;Population;prescription opioid;Process;Psyche structure;Public Health;public health intervention;public health priorities;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recovery;Research;response;scale up;Signal Transduction;smartphone application;Speed;Subgroup;synthetic opioid;United States National Institutes of Health;uptake;urban setting;usability;volunteer;willingness

PROJECT_TITLE: UnityPhilly Response App for Overdose Reversal: Assessing Citywide Effectiveness and Sustainability

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Burden of Illness;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dietary Supplements;Emerging Infectious Diseases;HIV/AIDS;Health Services;Infectious Diseases;Nutrition;Prevention;Rare Diseases;Tuberculosis

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE Undernutrition is a critical TB comorbidity and drives the TB epidemic in India. The NUTRIENT-India study will help quantify the long-term impact of nutritional interventions on TB incidence and mortality among persons with and without TB in India and define the most cost-effective nutritional interventions in the Indian context. Estimating cost-effectiveness of nutritional supplementation to mitigate the TB epidemic in India may incentivize Indian policymakers to wield nutritional policy effectively to attain their TB elimination goals.

PI_NAMEs: SINHA, PRANAY  (contact)

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adult;Age;age group;Alcohol consumption;Anti-Retroviral Agents;antiretroviral therapy;Bayesian Modeling;Body mass index;Calibration;Categories;CD4 Lymphocyte Count;Cessation of life;Characteristics;Clinical;clinical decision-making;cohort;comorbidity;cost;Cost Analysis;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost estimate;cost-effectiveness ratio;Country;Data;data streams;Diabetes Mellitus;Dietary Intervention;disability-adjusted life years;economic evaluation;Economic Policy;Effectiveness;Epidemic;falls;Food;Funding;Future;Goals;health economics;Health Policy;Health Surveys;Healthcare;HIV;HIV Seronegativity;HIV/TB;improved;Incentives;Incidence;incremental cost-effectiveness;India;Individual;insight;interest;Intervention;Investments;K-Series Research Career Programs;Language;Learning;Literature;Low Prevalence;Malnutrition;markov model;mathematical model;Mathematics;Mentorship;Modeling;models and simulation;modifiable risk;mortality;multidisciplinary;novel;nutrition;Nutritional;Nutritional status;Nutritional Study;nutritional supplementation;Observational Study;pandemic disease;Patients;Persons;Policies;Policy Maker;Population;Prevalence;programs;prospective;Public Health;Publishing;Research Personnel;Resolution;Resources;Risk Estimate;Risk Factors;Risk Reduction;sex;Smoking;South Africa;Surveys;systematic review;transmission process;Treatment Failure;Treatment outcome;Tuberculosis

PROJECT_TITLE: Nutritional Interventions to End Tuberculosis among persons with HIV in India (NUTRIENT-India)

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: Veterans are at increased risk for hematopoietic system diseases like leukemia. The only cure for many patients with these diseases is hematopoietic stem cell transplantation (HCT). However, the new immune system from the transplant (graft) often launches a multisystem attack against the patient (host), termed chronic graft-versus-host-disease (cGVHD). Treatment options are inadequate, and cGVHD will kill most long- term HCT survivors who overcome their original cancer. Clinical trials of promising new treatments as well as the ability to make optimal patient care decisions are thwarted by the absence of assessments to determine whether patients are responding to treatment or progressing. The proposed research will study the ability to objectively and reliably measure cGVHD in skin by a combination of innovative handheld, noninvasive tools: 3D photography, artificial intelligence, and the Myoton device. This may enable evidence-based, personalized cGVHD therapies and guide treatment decisions for improved outcomes in Veteran and other HCT survivors.

PI_NAMEs: TKACZYK, ERIC R (contact)

PROJECT_TERMS: 3-Dimensional;Address;Affect;Allogenic;Area;Artificial Intelligence;Assessment tool;Award;biomechanical test;Biomechanics;Body Surface Area;Categories;chronic graft versus host disease;Clinical;clinical examination;Clinical Trials;Color;Complex;convolutional neural network;Cutaneous;Cutaneous sclerosis;Data;Data Set;deep learning;Dermatologist;Devices;Diagnosis;digital;Digital Photography;Disease;Ensure;Erythema;Evaluation;evidence base;experience;follow-up;handheld equipment;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Hematopoietic System;Image;imaging modality;improved;improved outcome;innovation;leukemia;Light;Long-Term Survivors;Machine Learning;Malignant Neoplasms;Measurement;Measures;Mechanics;Methods;military veteran;Modeling;Monitor;mortality;Muscle;neural network;new technology;Organ;Palpation;Patient Care;Patient imaging;Patients;personalized therapeutic;Photography;Process;Property;prospective;Prospective cohort;Reproducibility;Research;response;Risk;Role;Sclerosis;Severity of illness;Skin;Skin Cancer;skin disorder;Surface;Symptoms;System;Technology;Testing;Therapeutic Trials;tool;Transplant Recipients;transplant survivor;Transplantation and Immune System;treatment response;United States National Institutes of Health;Validation;Veterans;viscoelasticity;Visit;Visualization;Work

PROJECT_TITLE: GVHD quantitative assessment in skin of Veterans post-HCT


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The Center for the Assessment of Tobacco Regulations (CAsToR) aims to provide evidence-based and expert-informed modeling of the behavioral and public health impacts of FDA tobacco rules or other regulatory actions, focusing on Impact Analysis, Behavior and Health Effects as Scientific Domains. In TCORS 3.0, CAsToR will have four projects based on the detailed analyses of current and historical tobacco use patterns in the US for the whole population and for key population subgroups.

PI_NAMEs: LEVY, DAVID THEODORE;MENDEZ EMILIEN, DAVID  (contact);MEZA, RAFAEL

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: addiction;Behavior;Behavioral;behavioral health;Behavioral Model;Cardiovascular Diseases;career;Characteristics;Cigar;comparative;Data;Data Analyses;data modeling;Decision Making;Education;Electronic cigarette;Electronic Nicotine Delivery Systems;Ethnic Origin;evidence base;Family Smoking Prevention and Tobacco Control Act;Flavoring;Future;Health;health warning;Individual;Infrastructure;insight;longitudinal analysis;Manufacturer;Marketing;Meta-Analysis;Modeling;models and simulation;Monitor;next generation;Nicotine;Nicotine Dependence;novel;Outcome;Pattern;Policies;Policy Analysis;Policy Maker;polytobacco use;Population;Population Assessment of Tobacco and Health;population health;Prevalence;Process;Public Health;public policy on tobacco;Race;Regulation;Research;Research Personnel;Respiratory Disease;response;Risk;Rural Population;Sales;Smoking;socioeconomics;Source;Subgroup;Surveys;systematic review;Tobacco;tobacco control;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco use;tool;Toxic effect;Training;Urban Population;vaping;Vulnerable Populations;Work;young adult;Youth

PROJECT_TITLE: Center for the Assessment of Tobacco Regulations (CAsToR) TCORS 3.0

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-R(50)R]


PI_NAMEs: LEVY, DAVID THEODORE (contact)

PROJECT_TERMS: Age;age related;Behavior;behavioral health;Calibration;Characteristics;Cigar;Cigarette;cohort;Collaborations;comparative;Consultations;Data;Data Analyses;data modeling;Disease Outcome;Electronic Nicotine Delivery Systems;evidence base;Family Smoking Prevention and Tobacco Control Act;flexibility;Future;Health;Health Surveys;heated tobacco products;Heterogeneity;Individual;longitudinal analysis;Marketing;Meta-Analysis;Methods;Modeling;models and simulation;Monitor;mortality;mortality risk;Nicotine;novel;Oral;Outcome;Pattern;Policies;Policy Analysis;Population;Population Assessment of Tobacco and Health;Prevalence;Public Health;Quasi-experiment;Race;Regulation;Relative Risks;Research;Research Project Grants;Review Literature;Sales;sex;simulation;Smoking;Socioeconomic Status;Specific qualifier value;Structure;Surveys;systematic review;Tobacco;tobacco control;tobacco products;tobacco regulation;Tobacco use;trend;Uncertainty;United States Food and Drug Administration;Variant

PROJECT_TITLE: Modeling the Impact of Novel Tobacco Product use on Smoking and Long-Term Health Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-R]


ADMINISTERING_IC: DE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative The complex sensory and structural defects of craniofacial disorders can be traced to an early period in embryogenesis, with the emergence of four multipotent cell lineages at the neural plate border. Of these four, the neural crest and pre-placodal lineages are most closely-related, respectively forming all facial bones and cartilage, as well as cranial sensory organs and nerves, in parallel. The goal of this project is to expand our knowledge of the distinct molecular mechanisms that govern placodal and neural crest progenitor fates by examining novel roles for the Foxi3 transcription factor and extracellular BMP signaling during border cell specification.

PI_NAMEs: MAUNSELL, HELEN RUTH (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Address;Affect;Anterior;ATAC-seq;bone;Cartilage;Cell Lineage;cell type;Cells;Central Nervous System;Cephalic;Characteristics;Chromatin;Classification;Cleft lip with or without cleft palate;Complex;Congenital Abnormality;craniofacial;craniofacial development;craniofacial disorder;Data;Development;Disease;Embryo;Embryonic Development;Epidermis;Epigenetic Process;extracellular;Face;face bone structure;Functional disorder;gastrulation;Genes;Genetic;genetic manipulation;Genetic Transcription;Goals;Impairment;in vivo;insight;Jaw;Knockout Mice;Knowledge;Label;Labyrinth;Methods;Molecular;multiple omics;multipotent cell;Mus;mutant;Mutation;Nerve;Neural Crest;Neural Crest Cell;neural plate;Neuroglia;Neurons;neurosensory;novel;novel marker;Null Lymphocytes;Olfactory Epithelium;Organ;Palate;Pathway interactions;Peripheral Nervous System;Phenotype;Population;Positioning Attribute;Process;progenitor;programs;Reconstructive Surgical Procedures;Reporter;response;Role;segregation;Sensory;Sensory impairment;Signal Induction;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Specific qualifier value;stem cell fate;stem cells;Structural defect;Structure;Syndrome;Testing;Time;Tissues;transcription factor;Transgenic Mice;Work;Zebrafish

PROJECT_TITLE: Molecular mechanisms regulating cranial sensory development

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Atherosclerosis;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Neurosciences;Patient Safety;Prevention;Stroke

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: In the United States, more than 100,000 carotid endarterectomy or stent procedures are performed annually on patients with narrowing of a carotid artery due to atherosclerosis who have not yet experienced symptoms of a stroke. Recent advances in medical management of atherosclerotic disease have raised questions regarding the net benefit of these procedures to prevent stroke. We are requesting support to complete two parallel multicenter randomized clinical trials, one comparing intensive medical management (IMM) vs. endarterectomy plus IMM (n=1240), the other comparing IMM vs. stenting plus IMM (n=1240).

PI_NAMEs: BROTT, THOMAS G;LAL, BRAJESH K;MESCHIA, JAMES F (contact)

PROGRAM_OFFICER_NAME: JANIS, SCOTT

PROJECT_TERMS: Abbreviations;Acceleration;Address;adjudication;Adult;Affect;Age;Alabama;Ancillary Study;Applications Grants;artery stenosis;Atherosclerosis;atherothrombosis;Blinded;Blood Pressure;Canada;cardiovascular risk factor;Carotid Arteries;Carotid Atherosclerotic Disease;Carotid Endarterectomy;Carotid Stenosis;Carotid stent;Cessation of life;cigarette smoking;Clinical;Clinical Trials;Clinical Trials Data Monitoring Committees;cognitive change;cognitive function;cognitive testing;cohort;Companions;compare effectiveness;Computer Assisted;COVID-19;COVID-19 pandemic;Credentialing;Data;Data Coordinating Center;data management;design;Detection;Devices;Diabetes Mellitus;Doppler Ultrasound;efficacy evaluation;Endarterectomy;Enrollment;Ensure;Event;experience;follow up assessment;follow-up;Funding;Goals;Hyperlipidemia;Hypertension;hypoperfusion;improved;Informed Consent;inhibitor;Ipsilateral;Knowledge;LDL Cholesterol Lipoproteins;Life Style;Lipoproteins;Medical;Medical Records;meetings;Modernization;Monitor;Multicenter Trials;operation;Operative Surgical Procedures;Outcome;Outcome Assessment;Outcome Study;Patient Recruitments;Patients;Periodicals;prevent;primary endpoint;primary outcome;Primary Prevention;Procedures;Proprotein Convertases;Protocols documentation;Radial;Randomized;randomized trial;randomized, clinical trials;Recommendation;recruit;Reporting;Research Design;Research Personnel;restenosis;revascularization;Risk;Risk Factors;Risk Reduction;safe patient;safety study;secondary endpoint;secondary outcome;Serine Protease;Severities;sex;Site;Spain;Standardization;Stenosis;Stents;Stroke;stroke event;Stroke prevention;stroke risk;Study Subject;Subtilisins;success;Surgeon;Symptoms;telephone delivery;Telephone Interviews;therapeutic target;treatment arm;treatment group;trial comparing;United States;Universities;vascular risk factor;Withdrawal

PROJECT_TITLE: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2)


PI_NAMEs: MENDEZ EMILIEN, DAVID  (contact)

PROJECT_TERMS: addiction;Addictive Behavior;Address;Adolescent;Adolescent and Young Adult;Adult;Affect;Affective;Age;Agreement;Behavior;Biological;Biological Factors;Brain;Cessation of life;combustible tobacco;Data;Decision Making;Demographic Factors;demographics;design;Education;Electronic cigarette;Electronic Nicotine Delivery Systems;Ensure;Environmental Risk Factor;experimental study;Future;Gender;Health;Human;Individual;Intention;Literature;Location;Long-Term Effects;Longitudinal Studies;Marketing;Modeling;National Longitudinal Survey of Adolescent to Adult Health;Neurosciences;next generation;Nicotine;Nicotine Dependence;nicotine use;novel;Pathway interactions;Policies;Population;Population Analysis;Population Assessment of Tobacco and Health;premature;pressure;prevent;Prevention;Process;Public Health;Publishing;Race;Regulation;Secure;Smoking;social;Social Environment;social factors;social influence;Social Network;social norm;Socioeconomic Status;Source;Structure;Surveys;Tobacco;tobacco products;tobacco regulation;Tobacco use;tool;transmission process;United States Food and Drug Administration;years of life lost;young adult;Youth

PROJECT_TITLE: Modeling the Process of Nicotine Addiction among Youths and Young Adults and Its Potential Future Consequences


ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: OVERALL: PROJECT NARRATIVE The overarching goal of the Virginia State University (VSU)-Virginia Commonwealth University (VCU) Massey Cancer Center (MCC) PartnErship for CancEr Disparities Research and Training (SUCCEED) program is to lead in the transformation of cancer-related outcomes for Virginians and to serve as a model of transdisciplinary disparities research. The institutions will jointly conduct pilot research projects addressing local, cancer-related health disparities and will develop a training program for VSU faculty and undergraduate students designed to attract and prepare investigators for careers in cancer disparities.

PI_NAMEs: SHEPPARD, VANESSA B;WINN, ROBERT A. (contact)

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TERMS: Address;Affect;African American;anti-cancer research;Black Populations;Black race;Cancer Burden;Cancer Center;cancer health disparity;career;career development;Cause of Death;Collaborations;Colorectal Cancer;Communities;community partnership;Comprehensive Cancer Center;Data;Death Rate;design;Development;Diagnosis;Disease;Disparity;Economics;Education;Elements;Emotional;Evaluation;experience;Faculty;Family;Fostering;Funding;Funding Agency;Goals;Growth;Health;Health Disparities Research;health disparity;health inequalities;Historically Black Colleges and Universities;Individual;Infrastructure;Institution;Intervention;Journals;K-Series Research Career Programs;Knowledge;Lead;Liver;Localized Malignant Neoplasm;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Massey Cancer Center at the Virginia Commonwealth University;meetings;member;Mentors;minority investigator;minority undergraduate;Modeling;mortality;multidisciplinary;Nature;neoplasm registry;Outcome;Output;Pattern;Peer Review;Phase;Pilot Projects;Positioning Attribute;Prevention;programs;Publications;Recording of previous events;Research;Research Activity;Research Personnel;Research Project Grants;research study;Research Support;Research Training;Resources;rural dwellers;science education;Social Well-Being;statistics;Students;summer research;survivorship;Testing;Training;Training Activity;Training and Education;Training Programs;undergraduate student;Underrepresented Minority;Universities;Virginia;Vision;Vital Statistics

PROJECT_TITLE: 1/2 VSU-MCC Partnership for Cancer Disparities Research and Training program (SUCCEED)


PI_NAMEs: FRIEDMAN, ABIGAIL S. (contact)

PROJECT_TERMS: Adolescent;Adoption;Adult;Affect;Area;Behavior;Border Crossings;Characteristics;Child;Cigar;Cigarette;cigarette smoking;cigarillos;combustible cigarette;Data;Data Set;design;Disparity;Effectiveness;Electronic Nicotine Delivery Systems;electronic vape;Ensure;Environment;Epidemic;Flavoring;Future;Geographic Factor;Health;Health behavior and outcomes;Individual;innovation;Laws;Legal system;Link;low socioeconomic status;Measures;Menthol;Methods;Modeling;Monitor;National Health Interview Survey;Nicotine;nicotine use;Outcome;Output;Participant;Patient Self-Report;Policies;Policy Analysis;Policy Maker;Public Health;public policy on tobacco;Quasi-experiment;Randomized;Regulation;Research;Research Design;response;Running;Rural;rural counties;rural disparities;rural dwellers;Sales;Smoking;Socioeconomic Status;Subgroup;Surveys;Taxes;Testing;Tobacco;tobacco flavor;tobacco products;tobacco regulation;Tobacco use;United States Food and Drug Administration;Urbanicity;vaping;Variant;Youth

PROJECT_TITLE: Assessing the Impact of Flavor Restrictions on Smoking and Vaping


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: WINN, ROBERT A. (contact)

PROJECT_TERMS: Advisory Committees;Animals;anti-cancer research;Cancer Center;cancer health disparity;Communication;Data;Doctor of Philosophy;Education Projects;education research;Educational workshop;Ensure;Environment;Evaluation;Expenditure;Funding;Future;Goals;Grant;Human Resources;human subject;Institution;Institutional Review Boards;Interruption;Leadership;meetings;member;Mission;Modeling;Monitor;Policies;pressure;Principal Investigator;Problem Solving;programs;Progress Reports;Publications;Research;Research Project Grants;Resource Allocation;Resources;Safety;Strategic Planning;System;timeline;Training;Training Programs;Universities;Virginia

PROJECT_TITLE: SUCCEED Administrative Core


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Orphan Drug;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_STATE: CT

PHR: PROJECT NARRATIVE DNA repair abnormalities occur frequently across human cancer types, presenting the potential for targeted tumor treatment via synthetic lethal approaches. We recently discovered a novel DNA modifying agent which generates DNA interstrand crosslinks specifically in tumor cells lacking the DNA direct repair enzyme O6- methylguanine-DNA methyltransferase (MGMT) and is effective in temozolomide (TMZ)-resistant glioma models. This proposal seeks to understand the therapeutic potential of this compound in a broader array of MGMT-deficient cancers, specifically by targeting additional defects in interstrand crosslink repair and by circumventing TMZ resistance.

PI_NAMEs: GUEBLE, SUSAN E (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Abnormal DNA Repair;Alkylating Agents;animal facility;Award;Basic Science;Bioinformatics;Biological Assay;Biology;cancer care;Cancer Histology;Cancer Patient;cancer type;Cell Line;Cell model;Cells;Clinical;clinical predictors;Clinical Trials;clinically relevant;Collaborations;collaborative environment;Colon Carcinoma;Combined Modality Therapy;CRISPR screen;crosslink;cytotoxicity;Databases;Dedications;Defect;Deposition;DNA;DNA Damage;DNA Interstrand Crosslinking;DNA Repair;DNA Repair Disorder;DNA Repair Gene;DNA Repair Pathway;Drug resistance;Effectiveness;efficacy evaluation;Equipment;experience;Fanconi's Anemia;functional loss;Funding;Glioblastoma;Glioma;Goals;homologous recombination;homologous recombination deficiency;Human;Hypermethylation;In Vitro;in vitro Model;in vivo;in vivo Model;Influentials;inhibitor;Institution;Islet Cell Tumor;Laboratories;Lead;Leadership;Lesion;Libraries;Malignant Neoplasms;Mediating;medical schools;Melanoma;Mentorship;MGMT gene;Mismatch Repair;Modeling;Molecular Biology;mouse model;neoplastic cell;Normal tissue morphology;novel;Paper;Pathway interactions;Patients;Poly(ADP-ribose) Polymerase Inhibitor;Positioning Attribute;Prevalence;Primary Lesion;Process;professor;promoter;Proteins;Publications;Publishing;Recurrence;repair enzyme;repaired;Research;research facility;Research Personnel;Resistance;resistance factors;resistance mechanism;Resources;response;Science;skills;System;targeted agent;targeted treatment;Technical Expertise;temozolomide;tenure track;Therapeutic;Therapeutic Agents;Therapeutic Radiology specialty;Toxic effect;Training;tumor;tumor xenograft;undergraduate student;Universities;Vision;Vocational Guidance;Work;Xenograft Model;Yale Cancer Center

PROJECT_TITLE: Therapeutic Potential of a Novel MGMT-Dependent DNA Interstrand Crosslinking Agent in the Treatment of DNA Repair Deficient Cancer