PI_NAMEs: MERTENS, JEROME S. (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Aging;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Area;Autopsy;Basic Science;biobank;Bioenergetics;Biological Aging;Biological Assay;Biological Markers;Biopsy;Cataloging;Cell Line;Cell model;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Collection;combat;Communities;Complex;Data;data management;Development;Disease;disease model;Etiology;exhaust;familial Alzheimer disease;Fibroblasts;Fostering;Generations;genome editing;Genomics;Goals;Health;Human;Human Genetics;Human Resources;Immune;Induced Neurons;induced pluripotent stem cell;Knowledge;Latin American;Latino;Latino Population;Metabolism;Modeling;Molecular;Nerve Degeneration;Nervous System Disorder;Neurons;Organoids;Participant;Pathology;Persons;Play;preservation;prevent;programs;Protocols documentation;Quality Control;Research;Research Personnel;Research Project Grants;Resources;Role;sample collection;Sampling;Services;skills;Skin;Societies;Somatic Cell;Source;stem cell model;Stem Cell Research;System;tool;Training;validation studies;vector;Work

PROJECT_TITLE: Core I: iPSC Core


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Genetics;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This proposal will establish scalable methods for linking neurons' molecular identities to synaptic inputs and outputs across the mammalian central nervous system. The molecular and connectivity information will be registered to a common atlas, allowing scale-up to the full brain. Once these methods have been developed, they have the potential to accelerate functional studies of neural circuits in a variety of species and brain areas, and disease states.

PI_NAMEs: DUAN, XIN  (contact);FEINBERG, EVAN HARRIMAN;YAO, SHENQIN

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: 3-Dimensional;Acceleration;Adoption;analytical tool;Anatomy;Antibodies;Area;Atlases;Axon;Bar Codes;Brain;brain cell;Brain region;cell type;Cells;Central Nervous System;computational pipelines;computational platform;Computing Methodologies;cost;cytotoxic;cytotoxicity;Data;Data Display;Data Set;denoising;Detection;Development;Disease;Dissociation;empowerment;Epitopes;Equipment;experimental study;Fluorescence;Gene Expression;Generations;Goals;imaging Segmentation;In Situ;information gathering;innovation;Investigation;Label;Libraries;Link;Location;machine learning method;Maps;Messenger RNA;Methods;Midbrain structure;model organism;Modernization;Molecular;Morphologic artifacts;Mus;neural;neural circuit;Neurons;Neurosciences;Oligonucleotides;Outcome;Output;Physiology;postsynaptic;postsynaptic neurons;presynaptic;presynaptic neurons;Process;Proteins;Protocols documentation;Rabies;rabies label;rabies viral tracing;Rabies virus;reconstruction;Research;Resources;RNA;scale up;Science;single-cell RNA sequencing;Slice;Sorting;Specificity;Structure;Synapses;System;Taxonomy;Techniques;Technology;Testing;Time;Tissues;tool;Tracer;transcriptome;transcriptomics;user-friendly;Viral;web portal;Work

PROJECT_TITLE: BRAIN CONNECTS: Scalable Approaches for Bidirectional Brain-wide Trans-Neuronal Connectivity Mapping of Defined Cell Types

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-S (17)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Digestive Diseases;Inflammatory Bowel Disease;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project narrative. Individuals with autism spectrum disorder (ASD) are more likely to have gastrointestinal dysfunction and inflammation and worsened gut symptoms co-occur with worsened behavioral and learning problems. The gut microbe Limosilactobacillus reuteri is observed in animal models and preliminary human trials to mitigate ASD and gut inflammation. This proposal aims to investigate the mechanism by which L. reuteri remediates these diseases and suggest a gut or microbial therapeutic for ASD and gut inflammation.

PI_NAMEs: BRITTON, ROBERT A (contact);DI RIENZI, SARA C

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Adult;Affect;Animal Model;Animals;Anti-Inflammatory Agents;Anxiety;associated symptom;autism spectrum disorder;Behavior;Behavioral;Body Weight decreased;Brain;Cell Proliferation;Child;Clinical;Colitis;Communication;Data;Defect;Disease;dosage;Epithelial Cells;Epithelium;Exposure to;Family suidae;Flare;Functional disorder;gastrointestinal;gastrointestinal epithelium;gut inflammation;gut microbes;gut-brain axis;high reward;high risk;Hormones;Human;Hypothalamic structure;Immune system;Incidence;Individual;individuals with autism spectrum disorder;Inflammation;Inflammatory Bowel Diseases;intestinal epithelium;Intestines;Investigation;Knock-out;Knockout Mice;Lactobacillus reuteri;Learning;Link;Location;Mediating;Microbe;microbial;microbiome;millisecond;model of autism spectrum disorder;mouse model;murine colitis;Mus;Nerve;novel;Oral;Oxytocin;Oxytocin Receptor;Pathogenicity;Pathology;Patients;Permeability;Pharmaceutical Preparations;Phenotype;prenatal exposure;remediation;repetitive behavior;Research;Role;Severities;Signal Transduction;social;Social Behavior;Social Interaction;social stress;Sodium Dextran Sulfate;Stress;success;Testing;Therapeutic;Tissues;transmission process;Valproic Acid

PROJECT_TITLE: Investigating the role of intestinal-derived oxytocin in social behavior and gut inflammation.

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: NEW ORLEANS

ORG_NAME: SOUTHEAST LOUISIANA VETERANS HEALTH CARE

ORG_STATE: LA

PHR: The research proposed in this grant will have a significant impact because when successfully completed it will fill key gaps in our understanding of the basic mechanism of insulin secretion in healthy men and insulin deficiency and type 2 diabetes in a large segment of the aging and androgen-deficient male population of the Veterans Healthcare system. This information will provide the foundation for development of approaches to modulate the androgen receptor (AR) to prevent diabetes without prostate or cardiovascular side effects. PHS 398/2590 (Rev. 11/07) Page Continuation Format Page

PI_NAMEs: MAUVAIS-JARVIS, FRANCK  (contact)

PROJECT_TERMS: Adenylate Cyclase;Aging;Agonist;Androgen Receptor;Androgens;Award;B-Lymphocytes;base;Beta Cell;Binding;Cardiovascular system;Cell membrane;Cell Physiology;clinically relevant;Complex;Cyclic AMP;Data;Dendrimers;Development;Diabetes Mellitus;Docking;Drug Targeting;Endosomes;Epidemic;Estrogen Nuclear Receptor;Exhibits;Failure;Foundations;FRAP1 gene;Functional disorder;Funding;Gene Modified;Genetic;GLP-I receptor;Glucagon;glucagon-like peptide 1;Glucose;Goals;Grant;Healthcare Systems;Human;human male;in vivo;innovation;Insulin;Insulin deficiency;insulin secretion;Investigation;islet;Islet Cell;Laboratories;Ligands;male;Maps;Mediating;Membrane;men;Methods;military veteran;Molecular;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nuclear;pharmacologic;Phosphatidylinositols;Phosphotransferases;Physiological;polypeptide;prevent;Production;Prostate;Publishing;Qualifying;receptor;Receptor Activation;recruit;Research;Role;side effect;Signal Transduction;src-Family Kinases;Stanolone;Structure of beta Cell of islet;Testing;Testosterone;Tissues;tool;transcription factor;Translating;Veterans;Work

PROJECT_TITLE: Role of the Androgen Receptor in Insulin Secretion in the Male


ADMINISTERING_IC: DC

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: BOSTON

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative This innovative multidisciplinary doctoral program trains researchers in Speech and Hearing sciences by combining broad exposure to relevant basic science and engineering disciplines, with rigorous expertise in at least one research area, and intense exposure to clinical practice. The program’s graduates are taking on leaderships roles in academia and industry where they work at the forefront of scientific discovery and develop novel assistive devices and therapies for those affected by disorders of hearing, voice, speech, language and balance. Some are combining research careers with clinical practice in otology, neurology, audiology or speech- language pathology.

PI_NAMEs: GELEOC, GWENAELLE S (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Hearing;Science;Speech;Training

PROJECT_TITLE: Training for Speech and Hearing Sciences


ORG_CITY: COLUMBIA

ORG_NAME: HARRY S. TRUMAN MEMORIAL VA HOSPITAL

ORG_STATE: MO

PHR: Project Narrative: Relevance to Veterans Health Corneal fibrosis (scarring) is a leading cause of blindness in veterans, military personnel, and civilians. Globally, 23 million people have corneal opacity/fibrosis in one eye and 4.9 million people are blind in both eyes. At present, 2 million veterans have impaired vision, >167,000 veterans are legally blind, and >7000 veterans develop blindness each year. Currently, corneal transplantation is standard of care to restore vision and no-specific drug therapies exist to cure corneal fibrosis without side effects in humans. The project leads development to novel mechanism-based non-surgical treatments to control active wound healing and established corneal scar in vivo, advance translation of the first non-surgical therapy for preexisting corneal fibrosis towards human clinical trials and identify mechanisms, targets, and strategies to prevent/treat corneal blindness from open-field blast injury. Successful completion of project fulfills the mission of the Veterans Health Administration to achieve excellence in research and offer best health care to veterans.

PI_NAMEs: JOHNSON, RUDOLPH ;MOHAN, RAJIV RAVINDRA (contact)

PROJECT_TERMS: 3-Dimensional;active control;Advanced Development;Affect;American;Autophagocytosis;BHLH Protein;Binding;Biological Assay;Blast Injuries;Blindness;Cardiac;Caring;CASP1 gene;Cell Physiology;Cells;Cellular Assay;Chronic;Cicatrix;Clinical;Clinical Trials;Cornea;Corneal Diseases;corneal epithelial wound healing;Corneal Injury;Corneal Opacity;corneal repair;corneal scar;Corneal Stroma;cytokine;Data;Development;Drops;Euthanasia;Event;Excision;Exposure to;Eye;Eyedrops;Fibroblasts;Fibrosis;Funding;Gene Silencing;gene therapy;Gene Transfer;gene-targeted therapy;Genes;Goals;Health;Healthcare;Histologic;Histology;Human;Image;In Vitro;in vitro Model;in vivo;Inflammation;Interleukins;Intervention;Keratoplasty;Knowledge;Lead;Legal Blindness;legally blind;Letters;Lung;MADH3 gene;MAP Kinase Gene;Mediating;Methods;Military Personnel;Mission;Missouri;Modeling;Molecular;Multimodal Imaging;multimodality;Mus;Myoblasts;Myofibroblast;nanomedicine;nanoparticle;Normal Cell;novel;novel strategies;ophthalmic examination;Oryctolagus cuniculus;Pathology;Patients;Persons;Pharmacotherapy;Phosphorus 32;Pilot Projects;Postoperative Period;pre-clinical;prevent;Prevention;Progress Reports;Property;Proteins;Publishing;Recycling;Research;Resolution;RNA Interference;Rodent Model;Role;Seminal;side effect;sight restoration;Signal Transduction;Site;standard of care;Testing;Therapeutic;Three-Dimensional Imaging;Time;tissue repair;Tissues;Translations;Transmission Electron Microscopy;treatment response;Veterans;Veterans Health Administration;Vision;Visual impairment;Visually Impaired Persons;Western Blotting;wound healing;Wound models

PROJECT_TITLE: Targeted Gene Therapy and Nanomedicine Approaches to Treat Corneal Diseases


ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: We are developing a visual prosthesis that can restore vision to the blind. The lateral geniculate nucleus (LGN) of the thalamus is an attractive site for implantation because it is spatially more expansive than the retina and thus enables higher acuity and a larger number of stimulation sites. At the same time, the neural signaling patterns used by LGN neurons are much less abstract than those of the visual cortex, thereby allowing for more straightforward encoding schemes with the prosthesis. While it has been challenging to develop a high- count, multi-channel device that can safely be implanted into a deep brain structure, our colleagues have recently developed such a device, and here we are studying how to effectively stimulate LGN neurons including how to optimize transmission to downstream cortical neurons. A functional LGN prosthesis is particularly attractive as it would be suitable for just about all blind patients, including returning battlefield soldiers and others who have suffered traumatic eye loss.

PI_NAMEs: FRIED, SHELLEY  (contact)

PROJECT_TERMS: Accidental Falls;Age;Age related macular degeneration;Aging;Anatomy;Animals;Area;area striata;Bilateral;blind;Blindness;Brain;cell type;Cells;Chronic;Clinical;Clinical Research;combat;Development;Device Designs;Devices;Diabetes Mellitus;Diabetic Retinopathy;Disease;Effectiveness;Electric Stimulation;Electrodes;Evaluation;Eye;Eye Injuries;Foundations;Future;General Population;Genetic;Glaucoma;Implant;implantable device;implantation;In Vitro;Individual;Investigation;Lateral Geniculate Body;Learning;Maps;member;Mental Depression;Mus;neural;Neurons;neurotransmission;Obesity;Ocular Prosthesis;optogenetics;Outcome;Pathway interactions;Patients;Pattern;Performance;Pharmacologic Substance;Physiology;Population;Positioning Attribute;preclinical study;Prosthesis;response;Retina;retina implantation;Scheme;Secondary to;Shapes;sight restoration;Signal Transduction;Site;Soldier;stem cells;Structure;Surface;Technology;Testing;Thalamic structure;Time;Tissues;transmission process;Trauma;Unemployment;Veterans;Vision;Visual;Visual Cortex

PROJECT_TITLE: Functional analysis of an LGN-based visual prosthesis


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative  The goal of this program is to enable remote C-H functionalizations by catalytic, radical mechanisms that are not possible by other methods. This strategy will facilitate rapid conversion of simple feedstock chemicals (alcohols, amines) to medicinally relevant, nitrogen-rich molecules (α-amino acids, β-amino alcohols, aza- heterocycles). Towards this end, the key enabling tactic of regioselective 1,5-hydrogen atom transfer (HAT) will be (1) rendered asymmetric and (2) intercepted by novel mechanisms – to yield unique reactivity and selectivity and streamline access to complex, biologically relevant molecules.

PI_NAMEs: NAGIB, DAVID A (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Radical Chaperones to Harness Remote, Selective C-H Functionalization Mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative The proposed research is relevant to public health because it will yield a better understanding of risk in autism and thus will lead to improved methods for prevention and treatment. By our exploration of de novo and transmitted variation, it is also relevant to the NIH mission and to the IACC recommendations around identifying genetic risk in ASD.

PI_NAMEs: BUXBAUM, JOSEPH D. (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Acceleration;Adult;Affect;analytical method;ANK2 gene;autism spectrum disorder;autism symptoms;Brain Diseases;cell type;Clinical;cohort;Copy Number Polymorphism;Data;Development;developmental disease;Diagnosis;Disease;disorder risk;exome;Family;First Pregnancy Trimester;Foundations;functional genomics;gain of function;gene discovery;General Population;Genes;Genetic;genetic architecture;Genetic Risk;Genetic Variation;genomic data;Goals;Heterogeneity;improved;Individual;Inherited;innovation;insertion/deletion mutation;insight;International;Knowledge;Learning;Link;loss of function;Mental disorders;Methods;Mission;Mutation;Neurodevelopmental Disorder;neuropsychiatric disorder;novel;novel therapeutics;Nucleotides;Outcome;Pathogenesis;Pathway interactions;Pattern;Play;Population;population based;Prevention;Process;Public Health;rare variant;Recommendation;repetitive behavior;Research;Research Project Grants;Resources;RFX3;Risk;risk variant;Role;Sampling;Sequence Analysis;sex;Signal Transduction;Site;social deficits;Source;Statistical Methods;Symptoms;therapeutic target;Trans-Omics for Precision Medicine;transmission process;United States National Institutes of Health;Variant;whole genome

PROJECT_TITLE: 1/4 - The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(60)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Antimicrobial Resistance;Behavioral and Social Science;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Mental Health;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Relevance to Public Health This randomized controlled trial will test whether a recently developed community-based intergenerational mentoring program known as Generation Exchange (GenX) can enhance antiviral resistance in a COVID- vulnerable population of older African-American women and men in a low-SES urban community. Additional studies will identify the biological processes that promote resistance to respiratory virus infections and viral disease in older African-American women and men.

PI_NAMEs: COLE, STEVE W (contact);SEEMAN, TERESA E

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: 2019-nCoV;active control;Address;African American population;African American Women;Age;Age disparity;age effect;Anti-viral resistance;Anti-viral Response;Antibodies;arm;Basic Science;biobehavior;Biochemical;Biological;biological adaptation to stress;Biological Factors;Biological Process;Biology;cell type;Cells;Chronic Disease;Clinical;Communities;community intervention;Coronavirus;COVID-19;COVID-19 pandemic;COVID-19 susceptibility;Cytotoxic T-Lymphocytes;Dendritic Cells;Disease;Disparity population;Education;Educational Status;falls;fighting;Gene Expression;Gene Expression Regulation;Gene Family;Generations;Genes;Genetic Transcription;Genomics;Goals;Health;HIV-1;Host resistance;Human;IL6 gene;Immune;In Vitro;Individual;infection rate;Inflammation;Inflammatory;Inflammatory Response;Influenza;Interferon Type I;intergenerational;Intervention;intervention program;Intervention Studies;Intervention Trial;Life;Link;Loneliness;low socioeconomic status;Maps;Meaning and purpose;Measures;Mediator;men;Mentors;monocyte;Obesity;Older Population;Overweight;Pathology;Pathway interactions;Personal Satisfaction;Persons;Physical activity;Pilot Projects;poor sleep;Population;primary endpoint;primary outcome;Process;programs;psychosocial;Public Health;racial disparity;Randomized;Randomized, Controlled Trials;Research;resilience;resilience factor;Resistance;Resistance to infection;respiratory infection virus;respiratory virus;response;Risk Factors;secondary endpoint;secondary outcome;sex;Signal Transduction;Sleep;social;social disparities;social engagement;social interventions;Social isolation;Social support;sociodemographic group;sociodemographics;socioeconomic disadvantage;Stress;Sympathetic Nervous System;T cell response;Testing;TNF gene;transcription factor;Urban Community;vaccine response;Viral;Viral Physiology;Virus Diseases;Vulnerable Populations;Woman

PROJECT_TITLE: Enhancing Innate Anti-Viral Resistance Through A Community-Based Intervention

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE Alcohol misuse exacerbates cognitive aging and increases the risk of Alzheimer’s disease and related dementia. Aging and chronic alcohol consumption both influence noradrenergic circuit functions. We combine brain imaging and longitudinal clinical assessment to investigate the noradrenergic mechanisms that underlie the effects of alcohol misuse on cognitive aging and the development of Alzheimer’s disease and related dementia.

PI_NAMEs: LI, CHIANG-SHAN RAY (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: abeta deposition;Acceleration;Acute;Address;Age;age related changes;Age-associated memory impairment;Aging;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol exposure;alcohol misuse;Alcohols;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Autopsy;Basal Nucleus of Meynert;Brain;Brain imaging;Brain region;burden of illness;Cells;cerebral atrophy;Cerebral cortex;Cessation of life;Chronic;chronic alcohol ingestion;cingulate cortex;Clinical;Clinical assessments;Clinical Research;Cognition;Cognitive;Cognitive aging;cognitive control;Cognitive deficits;cognitive function;cognitive performance;cognitive reserve;cognitive testing;Data;dementia risk;density;Development;drinking;Early Onset Alzheimer Disease;Emotional;Emotions;entorhinal cortex;epidemiology study;Etiology;Functional disorder;Functional Magnetic Resonance Imaging;Goals;healthy aging;Heavy Drinking;Hippocampus;Image;Impaired cognition;Individual;Intoxication;Life;Light;Link;Literature;locus ceruleus structure;Logistics;Longitudinal Studies;Magnetic Resonance Imaging;Mediating;Memory;mild cognitive impairment;modifiable risk;Molecular;Neocortex;Nerve Degeneration;neural;Neurofibrillary Tangles;neuroinflammation;neuromelanin;neuron loss;Neurons;Neuropil Threads;noradrenergic;older adult;Patients;Positron-Emission Tomography;preclinical study;Prefrontal Cortex;Prospective Studies;Reporting;response;Rest;Risk;Role;Severities;Sex Differences;Signal Transduction;social;Source;Staging;Structure;System;Thalamic structure;Time;Withdrawal;Woman

PROJECT_TITLE: Noradrenergic mechanisms of alcohol's impact on the development of MCI and early stage AD


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative The learning and un-learning of a fear response through conditioning and extinction learning is a process that is of interest not only for basic neuroscience research, but also for clinical intervention and diagnostic procedures in a variety of psychiatric disorders. In the present proposal, building on strong preliminary data that suggest a pivotal role of visual and attention systems, along with limbic structures, in aversive learning, we seek to use simultaneous EEG-fMRI, combined with computational modeling and advanced analytical techniques including machine learning, to characterize—in time and space—the dynamics and communication within and among the brain’s visual, attention and limbic networks during the acquisition and extinction of conditioned fear in healthy populations. Furthermore, testing of the proposed computational model on a community sample stratified by their cardiac reactivity to threat will advance our understanding of the model’s capability to differentiate individual differences in threat response, and lay the foundation for identifying new biomarkers and treatment targets for disorders of fear, anxiety, and post-traumatic stress.

PI_NAMEs: DING, MINGZHOU  (contact);KEIL, ANDREAS

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Acceleration;Address;advanced analytics;Amygdaloid structure;Animal Experiments;Animals;Anxiety;Area;Association Learning;Attention;attentional bias;attentional control;aversive conditioning;Behavior;Behavioral;Biological Markers;biomarker identification;Brain;Brain imaging;Cardiac;Clinical;Clinical Research;Communication;Communities;Complex;Computer Models;Computing Methodologies;conditioned fear;Conditioned Reflex;conditioning;Cues;Data;Deceleration;Diagnostic;Diagnostic Procedure;Disease;Disease susceptibility;Electrophysiology (science);Emotions;Etiology;Event-Related Potentials;executive function;experience;experimental study;Extinction;Foundations;Fright;Functional Magnetic Resonance Imaging;Goals;Heart Rate;hemodynamics;Human;imaging modality;indexing;Individual;Individual Differences;innovation;interest;Intervention;Laboratories;Learning;learning extinction;Limbic System;Machine Learning;machine learning algorithm;Measurement;Mental Depression;Mental disorders;Methods;Modeling;Monitor;Multimodal Imaging;multimodality;National Institute of Mental Health;neural;neuroimaging;Neurosciences Research;novel;Perception;Population;post-traumatic stress;potential biomarker;predictive modeling;Predisposition;Process;Psychophysics;Research;Research Domain Criteria;response;Role;Safety;Sampling;Scalp structure;Sensory;Shapes;Signal Transduction;Stimulus;Stress;Structure;Study models;System;Techniques;temporal measurement;Testing;Time;tool;Training;translational applications;Translational Research;Visual;Visual Cortex;Visual evoked cortical potential;visual neuroscience;Visual Perception;Work

PROJECT_TITLE: Acquisition, extinction, and recall of attention biases to threat: Computational modeling and multimodal brain imaging

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: MILWAUKEE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the T cell-mediated destruction of insulin-producing pancreatic b cells. CD8 T cells, with the help of CD4 T cells, are required for this destruction, however, the cellular mechanisms mediating this process remain incompletely understood. Therefore, the goal of this fellowship is to characterize a possible mechanism that may provide new therapeutic targets for the prevention and treatment of T1D.

PI_NAMEs: BROWN, ASHLEY K (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acceleration;Affect;Algorithms;Autoimmune;Autoimmune Diabetes;Autoimmune Diseases;autoreactive B cell;autoreactivity;B-Lymphocytes;Beta Cell;Biochemical Pathway;Bioenergetics;Bioinformatics;Blood;Body System;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Compartmentation;Cell Cycle Progression;cell growth;Cell Physiology;Cell Separation;Cell Survival;Cellular Metabolic Process;Childhood diabetes;chronic autoimmune disease;Clinical;clinically relevant;Complement;CRISPR/Cas technology;cytokine;Cytotoxic T-Lymphocytes;Data;Dependence;Development;Diabetes Mellitus;diabetic;diabetogenic;Disease;effector T cell;experimental study;Family;Fellowship;Financial Hardship;Genes;Genetic Transcription;Glucose;Goals;Histology;Immunologics;Immunology;In Vitro;Inbred NOD Mice;Incidence;Infiltration;Inflammation Mediators;Insulin;Insulin deficiency;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;integration site;interleukin-21;islet;kinase inhibitor;Knock-out;Knowledge;Manuscripts;Measures;Mediating;medical schools;meetings;Metabolic;metabolic profile;Metabolism;Mission;Mitochondria;Molecular;Moloney Leukemia Virus;Morphology;mouse model;multidisciplinary;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;Non obese;overexpression;Oxidative Stress;Pathway interactions;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;Physicians;PIM1 gene;prevent;Prevention;Process;Production;Protein-Serine-Threonine Kinases;proto-oncogene protein pim;Provirus Integration;Publications;Rag1 Mouse;Research;Research Institute;Risk;Role;Scientist;Severities;Signal Transduction;single-cell RNA sequencing;Structure;Structure of beta Cell of islet;T cell therapy;T-Cell Activation;T-Lymphocyte;Testing;Time;Training;transcriptomics;United States;Urine;Wisconsin;young adult

PROJECT_TITLE: Mechanisms by which PIM kinase modulates the effector function of autoreactive CD8 T cells in type 1 diabetes


NIH_SPENDING_CATS: Genetics;Human Genome;Kidney Disease;Regenerative Medicine

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative There is a longstanding gap of knowledge in the developmental role of the renal interstitium. Our proposed studies aim to understand how renal interstitial cell pattern is established and the function of this pattern. The proposed research will greatly enhance our capability to generate functional and mature nephron tubules for potential cell replacement therapy

PI_NAMEs: CARROLL, THOMAS JOSEPH (contact);PARK, JOO-SEOP

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Ablation;Anatomy;Binding;Bioinformatics;Biological Assay;Biology;cell cortex;Cell Lineage;cell replacement therapy;cell type;Cells;Cellular biology;Co-Immunoprecipitations;Complex;Data;Defect;Development;Distal;Duct (organ) structure;Endothelium;Enhancers;Epithelium;Fibroblasts;gain of function;Gene Expression;Gene Expression Profile;Genes;Genetic Epistasis;Genetic Transcription;genome-wide;Heterogeneity;Histologic;In Situ Hybridization;Individual;Injury to Kidney;insight;interstitial;interstitial cell;Kidney;Kidney Diseases;Knowledge;Ligands;Ligation;Location;loss of function;Maintenance;Maps;Modeling;Molecular;Mus;mutant;Natural regeneration;Nature;nephrogenesis;Nephrons;Newborn Infant;notch protein;Organ;Organoids;Pathway interactions;Pattern;Play;Population;promoter;Regulon;Renal Interstitial Cell;Research;Role;Signal Pathway;Signal Transduction;single cell analysis;single-cell RNA sequencing;Specific qualifier value;Testing;Tissue Engineering;Tissues;transcription factor;transcriptome sequencing

PROJECT_TITLE: The Role of Renal Interstitium in Kidney Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-J(05)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Heart Disease;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: WINSTON-SALEM

ORG_DEPT: SURGERY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative A poor understanding of the vascular etiology of Alzheimer’s disease and related dementias has hindered progress toward treatments and preventive strategies in older adults. Cardiac autonomic dysfunction, indexed by lower heart rate variability (HRV) or higher QT interval variability (QTV), may be associated with worse cognitive performance and incident dementia, yet most studies of HRV and QTV are limited by their short-term duration or imprecise computation that does not accurately capture autonomic function in real-world settings. The goal of this K01 Mentored Career Development Award is to obtain training in computing novel measures of extra long-term (14-day duration) ambulatory HRV and QTV that better represent autonomic function using an innovative signal processing method, and initiate a mentored research project to determine their association with cognitive performance and dementia risk in a large cohort of older US adults.

PI_NAMEs: SCHAICH, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Adult;Affect;age related;aging brain;Alzheimer's disease pathology;Alzheimer's disease related dementia;analytical tool;Area;Arrhythmia;Atherosclerosis Risk in Communities;Autonomic Dysfunction;Biological Markers;Blood Vessels;brain health;Brain region;brain volume;burden of illness;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;career;cerebral microbleeds;Cerebrovascular Disorders;Cerebrum;Cessation of life;circadian;Clinical;Cognition;Cognitive;cognitive function;cognitive performance;cognitive testing;cohort;Cohort Studies;Data;Dementia;dementia risk;Development;Devices;Disease Outcome;Diurnal Rhythm;Education;Electrocardiogram;Etiology;Event;executive function;experience;Future;Goals;Heart;Heart failure;heart rate variability;Hour;Impaired cognition;Impairment;Incidence;indexing;Infarction;innovation;insight;Intervention;K-Series Research Career Programs;Knowledge;Lacunar Infarctions;Language;Link;Literature;Longitudinal Studies;Measures;Memory;Mentored Research Scientist Development Award;Mentors;Methods;mild cognitive impairment;Morbidity - disease rate;mortality;Neurocognitive;neuroimaging;neuroimaging marker;Neurologic;Neurosciences;novel;older adult;Outcome;Parents;Participant;Performance;Perfusion;Periodicity;Persons;phenotypic data;population based;Prefrontal Cortex;Prevalence;Prevention strategy;Public Health;Research;Research Project Grants;Resources;Risk;Risk Factors;Role;signal processing;Signal Transduction;skills;Technology;tool;Training;translational study;treatment strategy;vascular contributions;Vascular Diseases;vascular risk factor;Ventricular;wearable device;White Matter Hyperintensity;Work

PROJECT_TITLE: Cardiac Autonomic Function, Cognitive Performance, and Neurocognitive Outcomes

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: The purpose of this proposal is to provide training in professional skills to a diverse group of PhD students in cellular, biochemical and molecular biology research that will enhance their ability to develop into independent scientists with careers in biomedical research-related fields. In addition to rigorous training in cellular and molecular-based scientific disciplines, the students will be involved in experiential learning in scientific communication, networking and mentoring, and career development. The goal is to prepare these trainees to become leaders in the scientific workforce in a supportive, safe, inclusive and academically rigorous environment.

PI_NAMEs: MCCULLOUGH, AMANDA K;TYNER, JEFFREY WALLACE (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: programs;Science

PROJECT_TITLE: Program in Biomedical Sciences

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ORG_CITY: BLACKSBURG

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Three-dimensional (3D) bioprinting has shown tremendous potential in constructing customized tissue models and implantable tissues. However, existing 3D bioprinters are incapable of printing biomimetic tissues with the resolution, complexity, and functions as native tissues. The proposed research will develop an acoustics-based 3D bioprinting technology, which overcomes these obstacles and enables biocompatible, fast, and scalable printing of functional biomimetic tissues with high resolution and complex features such as controlled anisotropic properties, high cell densities, and biomimetic cellular architectures.

PI_NAMEs: TIAN, ZHENHUA  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: 3-Dimensional;3D Print;Acoustics;Address;Anisotropy;anti-cancer research;Architecture;Area;Biological;Biological Models;biomaterial compatibility;Biomedical Research;Biomimetics;bioprinting;Blood capillaries;Blood Vessels;Cell Communication;Cell Density;Cell Physiology;Cell Shape;cell type;Cells;Communities;Complex;density;Development;Diameter;digital;Drug Screening;Emerging Technologies;Ensure;Face;Holography;Hydrogels;Implant;improved;In Vitro;in vitro Model;in vivo;Individual;Ink;instrument;internal control;invention;large print;Light;meter;Microfluidics;microsystems;Mississippi;Motor Neurons;Muscle;Muscle Fibers;neuromuscular;next generation;Pattern;Performance;photopolymerization;Physiological;polymerization;Polymers;Positioning Attribute;Printing;Property;Protocols documentation;prototype;Regenerative Medicine;Research;Research Personnel;Resolution;Rotation;scaffold;Series;Skeletal Muscle;spheroids;Structure;Surface;System;Technology;Tissue Engineering;Tissue Model;Tissues;tool;tumor;Vascular System;Vascularization

PROJECT_TITLE: Development of a multifunctional, acoustofluidic 3D bioprinter with single-cell resolution

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: STANFORD

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Drug resistance is a major impediment to the successful treatment of infectious disease and cancer. Although genetic mechanisms of drug resistance have been widely studied, non-genetic mechanisms may explain the extraordinary speed and frequency with which many medications can be rendered ineffective. The proposed research will establish how non-genetic drug resistance is acquired and maintained, and facilitate the development of novel therapeutic strategies targeting these mechanisms.

PI_NAMEs: XIE, JING LIN  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Aftercare;anti-fungal agents;Biological;Biology;Brefeldin A;Candida albicans;career development;Cells;Chemicals;Chromatin;Clinical;Clinical Microbiology;clinically relevant;Collaborations;Collection;combat;Communicable Diseases;Communities;CRISPR interference;CRISPR/Cas technology;design;Development;Development Plans;DNA Sequence;droplet sequencing;Drug resistance;Drug Tolerance;Educational process of instructing;Environment;epigenetic memory;Epigenetic Process;epigenetic variation;Evolution;Exposure to;fitness;Fluconazole;Fluconazole resistance;Fostering;Foundations;Frequencies;Gene Expression;Gene Expression Profile;Genetic;genetic approach;Genetic Transcription;genome-wide;Goals;Growth;Health Care Costs;Heritability;Heterogeneity;high throughput screening;Human;Human Pathology;improved;in silico;infectious disease treatment;Infrastructure;insight;Kinetics;Laboratories;Libraries;Maintenance;Malignant Neoplasms;Measurement;medical schools;Memory;Mentors;Methodology;Modeling;Molecular;mutant;Mutation;non-genetic;novel;novel therapeutic intervention;novel therapeutics;Outcome;overexpression;pathogenic fungus;pathogenic microbe;Patient-Focused Outcomes;Pharmaceutical Preparations;Phase;Phenocopy;Phenotype;Play;Population;Prevalence;programs;Proteins;proteostasis;Public Health;Research;research and development;Research Personnel;Research Training;Resistance;response;Series;single cell technology;single-cell RNA sequencing;skills;small molecule;Speed;Stress;Systems Biology;Technology;Testing;Therapeutic;Training;transcription factor;transcriptome sequencing;Treatment Failure;Universities;Variant;Work;Writing;yeast prion

PROJECT_TITLE: Understanding and targeting non-genetic mechanisms of drug resistance

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

PHR: Narrative The technological advances developed in this proposal will enable novel research capabilities relevant to the most pressing biomedical research problems today. New instrumentation and methodologies presented here will enable researchers to obtain deep structural and dynamics insight on a range of biological macromolecules, from membrane proteins to large macromolecular machines.

PI_NAMEs: RALSTON, CORIE Y (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Antibodies;Award;beamline;Binding;Biological;biological systems;Biomedical Research;biophysical techniques;biophysical tools;Blood capillaries;Cells;chromophore;Collection;Communities;Complex;Country;Data;Data Collection;data quality;detector;Development;Dose;Dose Rate;Dryness;Environment;Exclusion;experimental study;Exposure to;Fingerprint;flexibility;Fluorescence;Fluorescence Spectroscopy;Funding;Goals;Grant;Hybrids;improved;Injections;insight;instrument;instrumentation;Investigation;Kinetics;Light;Liquid substance;Location;macromolecular assembly;macromolecule;Maps;Mass Spectrum Analysis;Measurement;Membrane Proteins;Methodology;Methods;Microfluidics;Molecular Conformation;novel;protein complex;Protein Dynamics;protein structure;Proteins;Pump;Raman Spectrum Analysis;Research;Research Personnel;Resolution;Roentgen Rays;Sampling;small molecule;Solvents;Source;Spectrum Analysis;Speed;structural biology;Structure;success;Synchrotrons;System;Technology;Time;tool;Tube;Water;X ray spectroscopy

PROJECT_TITLE: Development of high-dose time-resolved X-ray footprinting technologies to enable detailed structural and kinetics information to be obtained for challenging biological problems

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Contraception/Reproduction;Estrogen;Heart Disease;Hypertension;Menopause;Prevention;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Aging women are at an increased risk for cardiovascular disease, which is the number-one killer of women in the US and women who enter menopause prematurely have a 50% increased risk of cardiovascular disease compared with women who enter menopause at a typical age. The proposed research aims to determine mechanisms that contribute to autonomic and blood pressure dysregulation in younger and older premature- and early-menopausal women, providing fundamental knowledge of the causes of hypertension and cardiovascular diseases in these women. Results from this study will inform future studies on prevention and treatment strategies to improve cardiovascular health in aging women.

PI_NAMEs: KELLER-ROSS, MANDA LINEA (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Address;Age;age effect;aged;Aging;aging process;arm;Attenuated;Automobile Driving;Autonomic Dysfunction;Autonomic nervous system;Baroreflex;Bilateral oophorectomy;Biological Aging;Biology of Aging;Biometry;Blood Pressure;blood pressure regulation;Cardiac health;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;career;Career Choice;career development;Cessation of life;clinical practice;Clinical Research;Clinical Skills;Data;design;Doctor of Philosophy;Early identification;early onset;Empirical Research;Estrogens;experience;Female;Foundations;Functional disorder;Funding;Future;Goals;Gonadal Steroid Hormones;Health;health disparity;human old age (65+);Hypertension;improved;innovation;insight;International;K-Series Research Career Programs;Knowledge;Laboratories;Link;Literature;Long-Term Effects;Measures;medical schools;men;Menopause;Mentored Research Scientist Development Award;Mentors;Mentorship;Minnesota;Mission;Morbidity - disease rate;mortality;Muscle;Nature;Nerve;normal aging;novel therapeutic intervention;older women;Outcome;Outcome Study;Ovarian;Ovary;Physical Medicine;Postmenopause;premature;Premature Menopause;Premenopause;Prevention strategy;Preventive therapy;professor;prophylactic;Qualifying;Rehabilitation therapy;Research;Research Activity;Rest;Scientist;sex;skill acquisition;skills;stressor;technique development;Techniques;Therapeutic;Training;Training Activity;treatment strategy;United States National Institutes of Health;Universities;Woman;Women's Health;Women's mortality

PROJECT_TITLE: Autonomic regulation of blood pressure in premature and early menopausal women

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: The overall goal of this predoctoral program is to offer exceptional interdisciplinary training in Molecular and Cellular Biology and Genetics with a concentration in cell signaling, epigenetics and genome maintenance. This program will provide a broad understanding of disease mechanisms and is aimed at developing in the trainees an in-depth understanding of the clinical challenges associated with their research interest area. Beyond scientific and state-of-the- art technical knowledge and translational research competencies, our goal is to develop in these trainees critical thinking and rigor, managerial, teaching and training skills, communication proficiency and a capacity for professional networking.

PI_NAMEs: GRANA, XAVIER  (contact);SOBOLOFF, JONATHAN A

PROGRAM_OFFICER_NAME: BROWN, ANISSA F

PROJECT_TERMS: Epigenetic Process;Genome;Maintenance;Molecular Biology;Molecular Genetics;Signal Transduction

PROJECT_TITLE: Molecular Biology and Genetics: Signaling, Epigenetics and Genome Maintenance


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Retroviruses are major causes of disease in animals and humans that replicate by reverse transcribing viral RNA into DNA. The initial immune response to retroviral infection is critical to the ability to clear infection, because once the viral DNA integrates into the host chromosomes, persistent infections arise, leading to diseases such as cancer and immunodeficiencies. Here we will examine the timing and location of virus replication and host response, using unique cell culture and mouse models developed by our lab.

PI_NAMEs: ROSS, SUSAN R (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Animals;APOCEC3G gene;apolipoprotein B mRNA editing enzyme;arm;Base Excision Repairs;Binding;Biological Models;Capsid;Cell Culture Techniques;Cell Nucleus;Cells;chemokine;Chromatin;Chromosomes;chronic infection;Code;Complex;cytokine;Cytoplasm;Data;Deamination;Dendritic Cells;Deoxycytidine;Deposition;Development;Disease;Dissociation;DNA;DNA Integration;ds-DNA;endonuclease;Enzymes;Escape Mutant;Eukaryota;Event;Evolution;Generations;Genetic Engineering;Genome;HIV;Human;Hybrids;Immune response;Immunity;Immunodeficiency and Cancer;In Vitro;in vivo;in vivo Model;Infection;Infectious Agent;Integrase;Interferon Type I;Knockout Mice;Ligands;Location;Lymphocyte;Macrophage;mammary tumor virus;Mediating;Membrane Fusion;Mouse Mammary Tumor Virus;mouse model;Murine leukemia virus;Mus;Mutation;Nuclear;Nucleic Acids;Organism;Peptides;Production;Prokaryotic Cells;Protein Family;Proteins;receptor;repair enzyme;repaired;response;Retroviridae;Retroviridae Infections;Reverse Transcription;RNA;RNA-Directed DNA Polymerase;Role;sensor;Single-Stranded DNA;System;Therapeutic Intervention;tool;Transcript;Transcription Initiation;TREX1 gene;Uracil;uracil-DNA glycosylase;Viral;viral DNA;Viral Genome;Viral Proteins;Viral Reverse Transcription;viral RNA;Virion;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Interplay between reverse transcription and host restriction

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Depression;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Microbiome;Pediatric;Pediatric - AIDS;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: Project Narrative We propose to study the impacts of socioeconomic, behavioral, and psychosocial impacts of COVID-19 pandemic and mitigation on adolescent girls in rural Kenya. We will examine these factors in relation to biological measures of stress, and how this relates to vaginal microbiome composition, Bacterial vaginosis, sexually transmitted infections, and HIV. This proposal advances global health and adolescent health, as the knowledge gained will support future policy and guidelines on school closures and the types of support adolescent girls need in the wake of similar future catastrophe.

PI_NAMEs: MEHTA, SUPRIYA DINESH (contact)

PROGRAM_OFFICER_NAME: YATES, FRANKLIN WILLEM

PROJECT_TERMS: Adolescent;adolescent health;Africa;Age;aged;Anxiety;Area;Bacterial Vaginosis;Behavior;Behavioral;Biological;Caring;Cessation of life;Characteristics;Chlamydia;cohort;Communities;Complex;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 risk;COVID-19 stress;Crime;Data;depressive symptoms;Economics;Enrollment;Environment;Estradiol;Estrogen decline;Estrogens;Evaluation;experience;Female Adolescents;Focus Groups;follow-up;food security;Future;girls;global health;Goals;Gonorrhea;Guidelines;harassment;hazard;Health Personnel;High School Student;HIV;Hormonal;Household;Housing;Human Herpesvirus 2;Human immunodeficiency virus test;Hydrocortisone;Income;Individual;infection risk;Interpersonal Violence;Intervention;Kenya;Knowledge;Lactobacillus;Logistics;low and middle-income countries;Measures;Mediating;Mediation;Mediator;Mental Depression;microbiome composition;Natural Disasters;Outcome;pandemic disease;pandemic response;Parents;Perception;Policies;Population;post-COVID-19;Pregnancy;Prevalence;prevent;Procedures;psychosocial;Publishing;Reporting;Research;response;Risk;Rural;rural area;Safety;school closure;school reopening;Schools;Secondary Schools;Series;sexual and reproductive health;Sexual Partners;Sexually Transmitted Diseases;social;Socioeconomic Factors;socioeconomics;Source;Specimen;Stress;stressor;Structure;teacher;therapy development;Time;tool;Trichomonas;Trichomonas Infections;Vagina;vaginal microbiome;Violence;Visit;Water;young woman;Youth

PROJECT_TITLE: Increased risk of STI and HIV among adolescent girls and young women due to COVID-19 and pandemic mitigation: Biological, behavioral, and psychosocial mediators

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision

ORG_CITY: Newark

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative The eye lens is a transparent organ responsible for fine focusing of light onto the retina. Two common age- related lens pathologies are: 1) cataracts, defined as any opacity in the lens, a leading cause of blindness worldwide and 2) presbyopia, a reduction in the lens' ability to change shape during focusing, which is linked to age-dependent increases in lens stiffness. This project will use a multiscale integrative approach to determine the fundamental mechanisms by which molecular regulation of actin filament networks controls nanoscale membrane structures and microscale cellular shapes and deformability, to establish macroscale biomechanical properties and transparency in genetic (mouse) and physiological (primate) models for the human lens.

PI_NAMEs: FOWLER, VELIA M (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Actin-Binding Protein;Actins;Address;Affect;Age;age related;alpha Actinin;Anterior eyeball segment structure;Apical;Architecture;Behavior;Binding;Biomechanics;Blindness;Cataract;Cell Differentiation process;Cell membrane;Cell Shape;Cell Surface Extensions;Cell-Matrix Junction;Cells;Cellular Morphology;Complement;Complex;confocal imaging;Confocal Microscopy;crosslink;Crosslinker;Crystalline Lens;Cytoskeleton;Data;Elasticity;Elements;Epithelial Cells;Epithelium;F-Actin;Family;fiber cell;Filament;Fimbrin;flexibility;fluorescence imaging;Future;gene function;Genetic;Goals;Growth;Human;Intercellular Junctions;Knowledge;Label;Lateral;lens;lens induction;lens transparency;Light;Link;Macaca;Measures;Mechanics;Mediating;Membrane;Microfilaments;Modeling;Molecular;Molecular Target;Morphology;mouse model;multiphoton imaging;multiphoton microscopy;Mus;nanoscale;non-muscle myosin;Nonmuscle Myosin Type IIA;Organ;Pathology;Pathway interactions;Peripheral;pharmacologic;Physiological;plastin;Play;predicting response;Presbyopia;prevent;Primates;Property;Protein Isoforms;Radial;recruit;Regulation;Reporter;resilience;response;Retina;Role;Scanning Electron Microscopy;Shapes;Stress Fibers;Structure;Testing;Thinness;Tissues;Tropomyosin;Visualization;Work

PROJECT_TITLE: Actin cytoskeleton regulation of lens architecture, transparency and mechanics

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE: CRISPR-Modified Cardiac Xenograft Transplantation In this proposal, we will rigorously test the hypothesis that hearts from “Pig 2.0” that express up to 12 xeno- targeted genetic modifications are protected from injury in clinically relevant preclinical heart xenotransplantation models. These studies are highly likely to be informative regarding mechanisms of Pig 2.0 cardiac xenograft injury or protection, and to contribute directly to development of a clinically applicable strategy for heart xenotransplantation.

PI_NAMEs: PIERSON, RICHARD N (contact)

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: Address;Adenosine;Adhesions;Adhesives;Antibodies;Binding;Biochemical;Biological Assay;Blood;Blood Coagulation Disorders;Blood Platelets;Cells;Clinic;Clinical;clinical application;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Coagulation Process;Complement;complement pathway;CRISPR gene drive;Data;design;Development;DNA cassette;Drug usage;Endothelium;Erythrocytes;ex vivo perfusion;Exhibits;experience;experimental study;Family suidae;Flow Cytometry;Functional disorder;gene editing technology;Gene Expression;Gene Modified;Genetic;Genetic Engineering;genetic regulatory protein;Genotype;Health;Heart;heart function;Heart Injuries;heart xenograft;Histology;Hour;Human;immunomodulatory therapies;immunoregulation;Immunosuppression;improved;In Vitro;in vivo;Inflammation;Injury;innovation;insight;Integrins;Intervention;Ischemia;Kidney;Knock-out;Learning;Leukocytes;Life;Liver;Lung;Measures;Mediating;Modeling;Modification;Monoclonal Antibodies;novel;Organ failure;Organ Transplantation;Papio;Pathway interactions;Pharmaceutical Preparations;Phenotype;Physiology;Positioning Attribute;pre-clinical;Predisposition;prevent;protein expression;Publishing;Refractory;Regimen;Regulator Genes;Reperfusion Injury;Reporting;Residual state;Resources;revascularization;Selectins;Steroids;Structure;targeted treatment;Testing;Thrombomodulin;thrombotic;TNFRSF5 gene;Transferase;Translating;Translations;Transplantation;Treatment Protocols;trial design;United States National Institutes of Health;Work;Xenograft Model;Xenograft procedure

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Mental Health;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Mental health depends critically on the capacity to simulate structural relationships in the environment. Surprisingly however, little is known about the underlying brain mechanisms of mental simulation. Our work aims to deepen our understanding of the computational principles and neural mechanisms of mental simulation. This knowledge would benefit the future development of rational diagnostics and therapeutics for mental health problems related to inference, prediction, and planning.

PI_NAMEs: FIETE, ILA R.;JAZAYERI, MEHRDAD  (contact)

PROJECT_TITLE: CRCNS: Computational principles of mental simulation in the entorhinal and parietal cortex


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: MISCELLANEOUS

ORG_STATE: CA

PHR: NARRATIVE: OVERALL The proposal aims to develop new technologies to fully utilize the unique capabilities of the World’s first X-ray laser to understand how the molecules of life are assembled and how they move. The new technologies will provide high quality images and movies of molecules, allowing to understand molecules work with or against each other. The project will work with experts in the fields of drug design and enzymology, to name a few, to design and build new capabilities that will be made available to all scientists.

PI_NAMEs: BOUTET, SEBASTIEN  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Active Sites;Address;Adenine;Antibiotics;Area;Automation;Automobile Driving;Back;base;Beds;beta-Lactamase;Binding;Biological;Biomedical Research;Biomedical Technology;Collaborations;Communities;community engagement;Complex;Coupled;Coupling;Cryoelectron Microscopy;Crystallography;cytochrome c oxidase;Data Analyses;Data Collection;design;Development;driving force;Drug Design;Educational workshop;Electron Microscopy;Ensure;Enzymatic Biochemistry;Experimental Designs;experimental study;Foundations;Future;G-Protein-Coupled Receptors;Generations;Genetic Transcription;Goals;Grant;Health;Health Services Research;Human;Image;improved;innovative technologies;instrumentation;Internet;Laboratories;Lasers;Length;Life;Light;Macromolecular Complexes;Measurement;Membrane Proteins;Metabolism;metalloenzyme;Methodological Studies;Methodology;Methods;movie;Names;Neisseria gonorrhoeae;neurotransmission;new technology;novel strategies;Physiologic pulse;Process;Production;programs;Property;Regulation;Research;Resource Development;Resources;Ribonucleotide Reductase;RNA Polymerase II;Roentgen Rays;Sampling;Science;Scientist;screening;Services;Signal Transduction;Source;Specificity;structural biology;Structure;success;synchrotron radiation;Synchrotrons;Technology;technology development;technology research and development;Testing;Time;tool;Training;Variant;Virus Diseases;Visualization;Work;x-ray free-electron laser

PROJECT_TITLE: Structural Dynamics at LCLS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(40)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

PHR: NARRATIVE: ADMINISTRATION AND MANAGEMENT A narrative is not required for this component of the proposal.

PROJECT_TERMS: Accountability;Advisory Committees;Automobile Driving;Award;Collaborations;Communication;Communities;Complement;Development;Ensure;experience;Funding;Funding Opportunities;Future;Institution;Light;Liquid substance;meetings;Molecular Biology;Monitor;Occupational activity of managing finances;Office of Administrative Management;operation;organizational structure;Output;Personnel Management;Procedures;Process;program dissemination;Recommendation;Reporting;Resources;Roentgen Rays;Role;Sampling;Scanning;Schedule;Services;Source;Strategic Planning;Structure;synchrotron radiation;synergism;System;Technology;technology research and development;Time;tool;Training Activity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J]


NIH_SPENDING_CATS: Rehabilitation

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative The number of successful researchers working in the area of deafness and other communication disorders is not sufficient to meet current needs. In this application, we propose a training program designed to bolster the research skills of clinicians and to introduce basic scientists to the study of communication disorders. Through this program, we can increase the proportion of PhDs who make substantive scientific contributions to our knowledge of the causes, diagnosis, and treatment of disorders of communication.

PI_NAMEs: STRICKLAND, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Communication impairment

PROJECT_TITLE: Communicative Disorders


PHR: NARRATIVE: TR&D-1 A narrative is not required for this component of the proposal.

PI_NAMEs: HUNTER, MARK  (contact)

PROJECT_TERMS: Active Sites;Automobile Driving;Biomedical Research;Collaborations;Communities;Complement;Complex;Data;Databases;Development;Development Plans;Dose;Electronics;Ensure;experimental study;Goals;high reward;high risk;improved;In Situ;interest;Laboratories;laboratory equipment;Measurement;Membrane Proteins;metalloenzyme;Methods;Monitor;novel diagnostics;Performance;Physiological;Preparation;Process;Property;Readiness;Research;Roentgen Rays;Sampling;Science;Services;Site;Source;structural biology;Structure;success;Synchrotrons;Technology;technology development;technology research and development;Temperature;Time;tool;wasting;Work;X ray diffraction analysis;x-ray free-electron laser


ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative The modification of proteins with the addition of a lipid group, S-acylation, is a tightly regulated, dynamic process with profound effects on many biological processes. The study of S-acylation using traditional experimental approaches, however, has proven technically challenging. This research program will build upon and further innovate chemical biology technologies to study the enzymes that install and remove this protein modification to ultimately define their role(s) in pathophysiologically-relevant contexts.

PI_NAMEs: DICKINSON, BRYAN  (contact)

PROJECT_TITLE: Chemical biology approaches to probe signaling by protein lipidation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(07)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PHR: Project Narrative: Alzheimer’s disease (AD) and related dementia syndromes (ADRD) represent an enormous challenge for patients, families, caregivers, and health care systems. Due to availability, cost, contraindications, and a number of other factors, currently available clinical diagnostic tools leave many people presenting with mild memory loss (and their families) with substantial uncertainty regarding their risk and likely rate of progression moving forward. In this project, we assess whether novel blood-based biomarkers of ADRD can be used to improve diagnosis and predict prospective rates of cognitive decline and thereby serve as powerful clinical and research tools.

PI_NAMEs: CHHATWAL, JASMEER P (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;American;Amyloid;amyloid precursor protein processing;Biological Markers;Blood;blood-based biomarker;Caregivers;Clinic;Clinical;clinical care;clinical diagnosis;clinical diagnostics;clinical predictors;Clinical Research;Cognition;Cognitive;cognitive performance;cost;Cross-Sectional Studies;Data;Dementia;design;Diagnosis;diagnostic tool;Disease Progression;Family;Family health status;flexibility;functional decline;Funding;Healthcare Systems;Hippocampus;Image;imaging biomarker;Immunoassay;Impaired cognition;Impairment;improved;in vivo;Light;Magnetic Resonance Imaging;Measures;Medical;Memory Loss;Modeling;N-terminal;Nerve Degeneration;neurofilament;neuroimaging;Neurology;novel;Participant;Pathologic;Pathology;Patients;Performance;Persons;Plasma;Population;Positron-Emission Tomography;predictive marker;Probability;prognostic model;prospective;Public Health;relative cost;Research;Research Personnel;research study;Risk;risk stratification;Sampling;secretase;Signal Transduction;Spinal Puncture;Syndrome;tau aggregation;tau Proteins;tau-1;Time;tool;Uncertainty;β-amyloid burden

PROJECT_TITLE: Plasma tau and neurodegenerative markers as predictors of rate of AD progression

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Narrative Proposed conferences are critical venues for shared work and dialogue and development of diverse scholars with expertise in time use, family inequality, and well-being over contexts and groups. Facilitating research how COVID-19 has affected daily behaviors, interactions, and well- being is an urgent new need. There are also critical needs to advance knowledge on underexplored topics, including time as a pathway for racial-ethnic differences in time use and health and time use as a social determinant of health across life stages and contexts.

PI_NAMEs: SAYER, LIANA C (contact)

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Agriculture;American;Behavior;career;Child;Child Health;Child Rearing;Communication;Communities;COVID-19;Data;Data Collection;data harmonization;Development;diaries;Discipline;Educational workshop;Effectiveness;Environment;ethnic difference;ethnic health disparity;experience;Family;Food;Funding;Gender;Geography;Government Agencies;graduate student;Grant;Health;health disparity;health disparity populations;health inequalities;Health Sciences;improved;Individual;Inequality;innovation;Interdisciplinary Study;interest;International;Knowledge;lens;Life;Life Cycle Stages;Life Experience;life span;Link;Maryland;Mentors;Methodology;National Institute of Child Health and Human Development;next generation;Obesity;Paper;Pathway interactions;Personal Satisfaction;Persons;Physical activity;Policies;Population Dynamics;population health;Population Research;post-pandemic;Postdoctoral Fellow;pre-pandemic;programs;Public Health;Public Policy;Publications;racial difference;racial health disparity;Recording of previous events;Request for Applications;Research;research and development;Research Personnel;Research Project Grants;Research Support;Resources;Role;Scholarship;Sleep;Social Change;social factors;social health determinants;Social Interaction;Social Sciences;statistics;Structural Racism;Surface;Surveys;symposium;Time;time use;tool;Underrepresented Populations;United States Department of Agriculture;Universities;Variant;virtual;webinar;Work;young adult

PROJECT_TITLE: Time Use Across the Life Course: Family Inequality and Multigenerational Well-Being

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


NIH_SPENDING_CATS: Biotechnology

PHR: NARRATIVE: TR&D-2 A narrative is not required for this component of the proposal.

PROJECT_TERMS: Automobile Driving;Beds;Biochemical Reaction;Collaborations;Color;Communities;Complex;Consumption;cryogenics;Crystallization;Crystallography;Data;Data Collection;Databases;density;design;Development;Development Plans;Devices;Diffusion;Drug Design;Enzymatic Biochemistry;experimental study;Exposure to;Feedback;fluid flow;Geometry;Goals;Lasers;Ligands;Liquid substance;Membrane;Membrane Proteins;metalloenzyme;Methods;Modeling;movie;Particle Size;Pathway interactions;Pattern;Phase;Physiologic pulse;Preparation;programs;Protein Array;Protein Dynamics;Radiation;Reaction;Research;Resolution;RNA;Roentgen Rays;Sampling;Scanning;Science;screening;Services;Stream;Structure;Surface Tension;Suspensions;System;Technology;Temperature;Testing;Thinness;Time;Viscosity;Work;x-ray free-electron laser


ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: Up to 20% of women Veterans (WV) using VHA primary care experience past-year intimate partner violence (IPV), which contributes to numerous physical and mental health conditions, including suicidality. Despite national recommendations to screen WVs for IPV, there is low adoption of IPV screening programs in primary care. In response, VHA is spreading IPV screening programs in Women’s Health Model 1 and Model 2 primary care clinics, where the majority of WV VHA primary care patients receive care. The systematic and effective implementation of IPV screening programs within primary care clinics is expected to enhance care for WVs as well as improve access to, and timeliness of, IPV-related care. Given the high prevalence of IPV among WVs and its significant negative health effects, successful implementation of IPV screening programs is expected to reduce morbidity among WV VHA patients.

PI_NAMEs: IVERSON, KATHERINE M (contact);MILLER, CHRISTOPHER JOSEPH

PROJECT_TERMS: Abnormal coordination;Academy;access disparities;Address;Adoption;Area;Caring;Clinic;Clinical;Clinical effectiveness;clinical practice;Community Services;compare effectiveness;Counseling;Data;Data Analyses;Data Collection;Dedications;design;Disclosure;Economics;Effectiveness;effectiveness outcome;effectiveness/implementation hybrid;Evaluation;Evidence based practice;experience;Forcible intercourse;Funding;future implementation;Gender;Health;health care service;health service use;High Prevalence;Hybrids;implementation barriers;implementation evaluation;implementation fidelity;implementation outcomes;implementation science;implementation strategy;Improve Access;improved;informant;innovation;interest;Intervention;Interview;intimate partner violence;Life;Maintenance;Managed Care Programs;Medicine;Mental Health;Mental Health Services;Methodology;Methods;Modeling;operation;Patients;Persons;Phase;physical conditioning;population health;Population Heterogeneity;Primary Care;primary care clinic;primary care patient;primary care visit;Process;Program Evaluation;programs;Promoting Action on Research Implementation in Health Services framework;Provider;Psyche structure;Psychiatric Social Work;Psychosocial Assessment and Care;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Records;Research;Resources;response;routine screening;screening;screening guidelines;Screening procedure;screening program;Services;Site;social;Social Work;Specific qualifier value;suicidal;suicidal risk;Suicide prevention;Surveys;telephone coaching;Testing;Time;Training;United States;United States Preventative Services Task Force;uptake;Veterans;Veterans Health Administration;Violence;virtual;Woman;Women's Health;Women's Health Services;women's morbidity

PROJECT_TITLE: Addressing Intimate Partner Violence Among Women Veterans: Evaluating the Impact and Effectiveness of VHA's Response.

STUDY_SECTION_NAME: Special Emphasis Panel[HS8A]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE 1.5 million patients die of TB every year partly due to delays in diagnosing the disease. The world needs faster, more accurate and/or less expensive diagnostics for TB and drug-resistant TB. We will identify, prioritize and evaluate promising new diagnostics across different use-cases in rigorous clinical studies and use the data to further develop and advance better and more reliable TB diagnostics for global use.

PI_NAMEs: CATTAMANCHI, ADITHYA ;DENKINGER, CLAUDIA MARIA;NAHID, PAYAM  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Address;Algorithms;authority;Award;Biotechnology;Caring;Characteristics;Clinical Research;clinical research site;Complement;cost;cost effective;Country;Data;data modeling;design;design verification;Development;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic algorithm;diagnostic development;Diagnostic tests;Diagnostics Research;disease diagnosis;Drug resistance;Drug resistance in tuberculosis;Ensure;Epidemiology;Evaluation;experience;Extreme drug resistant tuberculosis;Failure;Feedback;field study;flexibility;Fostering;Foundations;Geographic Locations;Geography;Goals;Guidelines;health economics;Health system;improved;Incubators;innovation;Laboratories;Leadership;Link;Medicine;Modeling;mortality;Multicenter Studies;next generation;novel;novel diagnostics;Organizational Policy;Outcome;Patients;Performance;Pharmaceutical Preparations;Phase;Policies;Population;Predisposition;Process;prototype;Public Health;Recording of previous events;Regimen;Research;Research Personnel;Site;Special Population;Specific qualifier value;Structure;Study models;Technology;Testing;transmission process;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;Update;usability;World Health Organization

PROJECT_TITLE: Rapid Research for Diagnostics Development in TB Network (R2D2 TB Network)


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Rural Health;Social Determinants of Health

PHR: PROJECT NARRATIVE The Rural Environmental Health Training Program will provide environmental health sciences training across three focus areas: mechanisms of environmentally-mediated diseases prevalent in rural areas, community- engaged and epidemiological approaches designed for population sparse areas, and exposure science. Trainees will apply these approaches to further our understanding of toxicological mechanisms, characterize exposures and design environmental health interventions to lessen rural health disparities.

PI_NAMEs: GOHLKE, JULIA M (contact);POELZING, STEVEN

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(T)]


PHR: NARRATIVE: TR&D-3 A narrative is not required for this component of the proposal.

PROJECT_TERMS: Algorithms;Area;Attention;Automation;beamline;Biochemical Reaction;biological systems;Collaborations;Communities;Consumption;Data;Data Analyses;data analysis pipeline;Data Collection;data quality;Data Set;data streams;Development;Development Plans;Electronics;Equilibrium;Evolution;experience;experimental study;Failure;Feedback;G-Protein-Coupled Receptors;Genomics;Goals;Human;Human Resources;improved;innovation;Intervention;Lasers;Lighting;Measurement;Measures;Metalloproteins;Metals;Methods;Monitor;Optics;Outcome;Physiological;Process;programs;Protein Dynamics;Proteins;Pump;Reaction;Resources;RNA Polymerase II;Safety;Sampling;Science;sensor;Series;Services;Signal Transduction;software systems;Source;structural biology;Structure;success;System;Techniques;technology research and development;Temperature;temperature jump;temporal measurement;Time;Ultraviolet Rays;Visible Radiation


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Palliative Care;Patient Safety;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: PEDIATRICS

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Although most children with cancer are cured long-term, 10-15% of children will ultimately develop advanced, incurable illness, rendering cancer the leading cause of non-accidental death in children. Currently, no measures exist to assess the quality of care children with cancer receive near the end of life. The proposed research will help develop family-centered measures of high quality end-of-life care and test novel methods of evaluating quality.

PI_NAMEs: ANANTH, PRASANNA J (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Academy;Address;Adult;Advanced Malignant Neoplasm;Advisory Committees;Artificial Intelligence;Award;Bereavement;cancer care;care delivery;career;career development;Caregivers;Caring;Cessation of life;Child;Child Care;Childhood;Clinical;Cognitive;cohort;Cohort Studies;Data;Data Collection;Data Sources;design;Development Plans;Electronic Health Record;end of life;end of life care;Equity;Evaluation;evidence base;experience;experimental study;Face;Family;Foundations;Goals;health assessment;health care service utilization;Healthcare;hospice environment;hospice utilization;Hospitalization;improved;Intubation;Investigation;Knowledge;Leadership;Length of Stay;Libraries;Life;Malignant Childhood Neoplasm;Malignant Neoplasms;Manuals;Measurement;Measures;Medicine;Mentorship;Methods;Minority;multimodality;Natural Language Processing;Non-accidental;novel;Outcome;Pain;Palliative Care;Parents;patient oriented;Patient Outcomes Assessments;Patients;preference;Procedures;Process;Process Measure;programs;Property;prospective;Provider;provider communication;Psychometrics;Quality of Care;Questionnaire Designs;Questionnaires;Reporting;Research;Research Personnel;Research Technics;Resources;Sampling;Science;skills;Structure;Surveys;Symptoms;Testing;tool;Training;Training Activity;trend;Validation;Work

PROJECT_TITLE: The Pediatric Advanced Cancer Experience (PACE): Measuring Quality of End-of-Life Care for Children with Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


PHR: NARRATIVE: DRIVING BIOMEDICAL PROJECTS PORTFOLIO A narrative is not required for this component of the proposal.

PROJECT_TERMS: Active Sites;Adenine;Antibiotics;Area;Automobile Driving;Beds;beta-Lactamase;Binding;Biochemical Reaction;Communities;cytochrome c oxidase;Development;Emerging Technologies;Equilibrium;experimental study;Goals;improved;interest;Life Cycle Stages;Light;Macromolecular Complexes;macromolecule;Membrane Proteins;metalloenzyme;method development;Methodology;Methods;Molecular Conformation;Motivation;Neisseria gonorrhoeae;Process;programs;Research;Research Personnel;Ribonucleotide Reductase;RNA Polymerase II;Roentgen Rays;Selection Criteria;Signal Transduction;Source;Specificity;Structure;Technology;technology development;temporal measurement;Testing;Time;tool;Training;United States National Institutes of Health;Variant;willingness;x-ray free-electron laser


NIH_SPENDING_CATS: Genetics;Hematology;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: NARRATIVE The development and function of the hematopoietic system require precisely regulated gene expression programs orchestrated by noncoding regulatory DNA sequences such as transcriptional enhancers. This project aims to fill a critical gap by developing new approaches to dissect the molecular composition of tissue- specific enhancers in native chromatin during erythroid differentiation and hematopoiesis. Given that noncoding regulatory elements are frequently targeted by disease-associated genetic variations, these studies may provide new strategies for developing mechanism-based therapeutics for genetic or acquired blood disorders.

PI_NAMEs: XU, JIAN  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: 3-Dimensional;Address;Affinity;Biotinylation;Cell Differentiation process;Cell Fate Control;cell type;Cells;Chromatin;Chromatin Structure;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Complex;CRISPR/Cas technology;Data;Development;Differentiation Therapy;Disease;DNA;DNA Sequence;Elements;Engineering;Enhancers;Epigenetic Process;Erythroid;Erythroid Cells;erythroid differentiation;Erythroid Progenitor Cells;Fetal Hemoglobin;Funding;GATA1 gene;Gene Expression;Gene Targeting;Genetic;Genetic Transcription;genetic variant;Genetic Variation;genome-wide;genome-wide analysis;Genomics;Goals;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic differentiation;Hematopoietic stem cells;Hematopoietic System;human disease;In Situ;in vivo;Individual;innovation;Investigation;Knock-in Mouse;Label;Link;Maps;Mediating;Molecular;Molecular Analysis;mouse model;novel strategies;novel therapeutics;Pathologic;pharmacologic;Physiological;Process;programs;Proteins;Proteomics;Regulation;Regulatory Element;Repression;Repressor Proteins;Resolution;RNA;Role;spatiotemporal;Specific qualifier value;Specificity;Stem Cell Development;Structure;System;Technology;Testing;Therapeutic;Tissues;tool;trait;transcription factor;Transcriptional Regulation;Untranslated RNA;Work

PROJECT_TITLE: Molecular Analysis of Transcriptional Enhancers in Hematopoiesis

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


PHR: NARRATIVE: COMMUNITY ENGAGEMENT A narrative is not required for this component of the proposal.

PROJECT_TERMS: Area;Automobile Driving;Awareness;Collaborations;Communities;community engagement;Computer software;Data;design;Development;Educational workshop;Effectiveness;Ensure;Environment;experience;Feedback;Goals;graduate student;Growth;improved;Information Dissemination;Internet;Knowledge;Laboratories;laboratory experience;Licensing;meetings;Methodology;Methods;Mission;new technology;Online Systems;operation;Process;program dissemination;Publications;Qualifying;Research;Research Personnel;Resources;Roentgen Rays;Scientist;Services;Source;student training;symposium;Synchrotrons;Technology;technology research and development;technology training;Testing;tool;Training;web site;Work


ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project narrative The Molecular Biophysics Training Program is designed to yield a cohort of new PhDs with the skills to apply quantitative approaches rooted in physics to biomedical problems. The program will draw students from bi- institutional graduate programs shared between Weill Cornell Medicine and Sloan Kettering Institute. It will generate scientifically rigorous, thematically organized, socially cohesive and broadly inclusive educational and training environments to prepare students for diverse careers in academic and non-academic fields following timely completion of their doctoral degrees.

PI_NAMEs: BOUDKER, OLGA ;ELIEZER, DAVID  (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Biophysics;Molecular;Training Programs

PROJECT_TITLE: Molecular Biophysics Training Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Cardiovascular disease is the leading cause of morbidity and mortality in the US and worldwide, and there is a significant need for training a new generation of investigators in next-generation technologies to solve this complex disease. This Training Program will equip an elite group of pre-doctoral and post-doctoral scholars to become the next-generation of scientists and physician scientists capable of discovering cures for Cardiovascular Disease

PI_NAMEs: KOZAR, ROSEMARY A;STRICKLAND, DUDLEY K. (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TITLE: Interdisciplinary Training Program in Cardiovascular Disease

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Project Narrative Pancreatic β cells secrete insulin into the vasculature at specific locations called secretion hot spots, where various cytoskeletal and mechanosensitive proteins localize and modulate secretion levels. Since the mechanisms of this regulation are to a large extend elusive, I propose to determine details of organization of the cytoskeletal networks at hot spots and test if their molecular interplay regulates insulin secretion toward the vasculature. Understanding these molecular mechanisms may have high impact by providing potential targets for restoring normal glucose-stimulated insulin secretion in type 2 diabetes.

PI_NAMEs: FYE, MARGRET A (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Actins;Actomyosin;Address;Adhesions;Architecture;Area;Beta Cell;Biological Assay;Blood Glucose;blood glucose regulation;Blood Vessels;Cell membrane;Cell Physiology;Cells;Compensation;Complex;Computer Analysis;Coupled;Couples;Cytoskeletal Modeling;Cytoskeleton;Diabetes Mellitus;Docking;Dominant-Negative Mutation;Dyes;Elements;Event;Exocytosis;Extracellular Matrix;Face;Fluorescence Resonance Energy Transfer;FluoZin-3;Focal Adhesions;Glucose;Guanine Nucleotide Exchange Factors;Hot Spot;Imaging Techniques;improved;Insulin;insulin granule;insulin regulation;Insulin Resistance;insulin secretion;islet;Islets of Langerhans;Knowledge;Label;Laboratories;live cell imaging;Location;Mediating;Mediator;Microtubule Depolymerization;Microtubules;Minus End of the Microtubule;Modeling;Molecular;Monomeric GTP-Binding Proteins;Morphology;Mus;Myosin Type II;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel;Nucleotides;Nutrient;Peripheral;pharmacologic;Play;Plus End of the Microtubule;Positioning Attribute;Process;Proteins;Regulation;Role;sensor;Signal Transduction;Structure of beta Cell of islet;Testing;Therapeutic;therapeutic target;Tissues;Total Internal Reflection Fluorescent;ultra high resolution;Visualization;voltage

PROJECT_TITLE: Cytoskeleton-mediated regulation of insulin secretion hot spots in pancreatic beta cells


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: WASHINGTON

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative This training program will provide scientific and professional development for PhD students and postdoctoral fellows pursuing research careers focused on the brain basis of speech, language, and communication. The program activities emphasize cross-disciplinary training, clinical experiences, community engagement, and professional development in order to produce well-rounded scientists who have a broad perspective on how their research impacts the community at large. This type of training will hopefully lead to high rates of retention of successful service-minded scientists who will make important discoveries and engage with communities who may benefit from research on the brain basis of communication.

PI_NAMEs: TURKELTAUB, PETER ETHAN (contact)

PROJECT_TITLE: Georgetown University Brain and Language Training Program


ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

ORG_STATE: TX

PHR: Chronic kidney disease (CKD) is a major public health problem, afflicting an estimated 37 millions of US adults and among Veterans, the prevalence of CKD is nearly 50% higher than that of the US general population. CKD is associated with maladaptive cardiac remodeling resulting from impairments in insulin/insulin like growth factor-1 receptor (IGF1R) signaling. We have identified a novel mechanism: signal regulatory protein alpha (SIRPα) that interferes with myocardial insulin/IGF-1 receptor functions resulting in CKD-induced cardiomyopathy. This discovery will stimulate novel targets for therapies to prevent CKD-associated heart failure.

PI_NAMEs: THOMAS, SANDHYA S (contact)

PROJECT_TERMS: Adipose tissue;Adult;adverse outcome;Autophagocytosis;Cachexia;Cardiac;Cardiac Myocytes;Cardiometabolic Disease;Cardiomyopathies;Cardiorenal syndrome;Cardiovascular Diseases;cell type;Chronic Kidney Failure;Circulation;Complication;Culture Media;Data;Defect;Development;Fibroblasts;FRAP1 gene;General Population;Goals;Growth;Growth Factor;Heart;Heart failure;heart function;Impairment;improved;Inflammation;Insulin;Insulin Receptor;Insulin Resistance;Insulin-Like-Growth Factor I Receptor;Kidney Diseases;Knock-out;Knockout Mice;Knowledge;Macrophage;Measures;Mediating;Mediator;Metabolic;Molecular;mortality;multicatalytic endopeptidase complex;Mus;Muscle;muscle form;Myocardial;Myocardial dysfunction;Myocardium;new therapeutic target;novel;Pathway interactions;Patients;potential biomarker;Prevalence;prevent;Protein Biosynthesis;protein degradation;Protein Dephosphorylation;Protein Tyrosine Phosphatase;PTPN11 gene;Public Health;receptor;receptor binding;receptor function;Receptor Signaling;Recombinants;recruit;Resistance;response;Role;Serum;SHPS-1 protein;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;Sulfate;System;targeted biomarker;Testing;therapeutic target;Toxin;Tyrosine;Ubiquitin;Uremia;uremic cardiomyopathy;Veterans

PROJECT_TITLE: Chronic Kidney Disease-Induced Defects Initiated by SIRPα


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Alzheimer’s Disease is a currently incurable brain disease. Brain entropy is an important trait of brain function and may provide critical information for unveiling neuromechanisms of complex disorders like AD. Using large existing data, this project will examine brain entropy change in AD and to assess brain entropy as a potential biomarker for AD. Given our aging population and the increasing prevalence of AD, performing this project is likely to have significant public health impact.

PI_NAMEs: WANG, ZE  (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Acceleration;Affect;Age;Aging;aging population;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;Area;Biological Markers;Brain;Brain Diseases;Brain Injuries;Clinical;Cognition;Cognitive;cognitive control;cognitive function;cognitive reserve;Compensation;Complex;Consumption;Data;Data Set;deep learning;Dementia;Detection;Deterioration;disability;Disease;Disease Management;Education;Elderly;Entropy;experience;Failure;Functional Magnetic Resonance Imaging;functional outcomes;Future;glucose metabolism;Hippocampus;imaging biomarker;Impaired cognition;improved;Individual;Intervention;Knowledge;Language;Literature;machine learning method;Magnetic Resonance Imaging;Maps;Measurement;Measures;medial temporal lobe;Memory;men;method development;mild cognitive impairment;Modeling;neuroimaging;neuroimaging marker;neuromechanism;normal aging;Normal Range;novel;open source;Outcome;Pain;Pathology;Patients;Pattern;Persons;Positron-Emission Tomography;potential biomarker;predictive modeling;Prefrontal Cortex;Prevalence;public database;Public Health;Publishing;Reporting;Research;Research Personnel;Rest;Role;Severity of illness;sex;Shapes;support vector machine;Symptoms;tau Proteins;Testing;therapy development;tool;trait;translational study;uptake;Woman;Work

PROJECT_TITLE: Brain entropy mapping in Alzheimer's Disease


NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: My laboratory is studying the signaling pathways that may be responsible for the development of primary open angle glaucoma (POAG). POAG is an age-related, chronic optic neuropathy that results in irreversible blindness. A major cause of POAG is the increase in the expression of TGFβ2. The goal of this grant is to study how the coordinated activities of the Calcineurin/NFATc1 and αvβ3 integrin pathways can drive the expression of TGFβ2 by creating a positive feedback loop.

PI_NAMEs: PETERS, DONNA M (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Adenovirus Vector;age related;Anterior;anterior chamber;Aqueous Humor;Binding;Biological Process;Blindness;Calcineurin;Cannulations;cell type;Cells;cellular transduction;Chelating Agents;Chronic;Clinical;Combined Modality Therapy;connective tissue growth factor;Deposition;Development;Dexamethasone;early onset;Etiology;Extracellular Matrix;Extracellular Matrix Proteins;Feedback;Fibronectins;Fibrosis;Genetic Transcription;Glaucoma;Glucocorticoids;Goals;Grant;Human;Immunofluorescence Microscopy;In Vitro;in vivo;Injections;Integrin alphaVbeta3;Integrin Signaling Pathway;Integrins;Ionomycin;Ionophores;Laboratories;LoxP-flanked allele;Luciferases;Measures;mechanical force;Mechanics;Monkeys;Mus;myocilin;novel;nuclear factors of activated T-cells;optic nerve disorder;overexpression;Pathway interactions;Patients;Phosphoric Monoester Hydrolases;Physiologic Intraocular Pressure;pressure;prevent;Primary Open Angle Glaucoma;Property;Protein Isoforms;Proteins;Reporter;Role;Signal Pathway;Signal Transduction;small hairpin RNA;Stretching;Testing;Tissues;Trabecular meshwork structure;transcription factor;Transcriptional Activation;Transforming Growth Factor beta;Transgenes;vector;Western Blotting;Work

PROJECT_TITLE: NFAT and fibrosis in the trabecular meshwork

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: Narrative The International Agency for the Prevention of Blindness’s Vision Atlas reports that as of 2021 there are 43 million people living with blindness and 295 million people who have moderate to severe vision impairment. In the US there are 12 million people with visual impairment, including one million people who are blind. The Training Program in the Molecular Bases of Eye Diseases has as its goal to train scientists who will use a wide range of disciplines to elucidate the causes of visual impairment and blinding diseases with the aim of developing methods for earlier diagnosis, more effective treatments, means for prevention and eventually to develop cures.

PI_NAMEs: D'AMORE, PATRICIA ANN (contact);GREGORY-KSANDER, MEREDITH

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Narrative Individuals can be predisposed to specific cancers, such as blood cancers, by inherited variation. We have begun to define this variation, but we do not understand why it can predispose individuals to acquire blood cancers. In this grant, we will study the pressures that arise from these inherited risk variants that promote blood cancer emergence.

PI_NAMEs: SANKARAN, VIJAY GANESH (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Address;Alleles;cancer risk;Cells;CHEK2 gene;Coupling;Data;Development;Disease;disorder risk;DNA Sequence Alteration;Downstream Enhancer;Enhancers;epidemiology study;follow-up;Genes;Genetic;genetic association;Genetic Variation;genome editing;genome sequencing;genome wide association study;genome-wide;Germ Lines;GFI1B gene;Grant;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Heritability;Human;Individual;Inherited;innovation;insight;Laboratories;Libraries;loss of function;Malignant Neoplasms;Modeling;mouse model;Mus;Myeloproliferative disease;polygenic risk score;Predisposition;pressure;Process;Property;Regulatory Element;Risk;risk variant;Role;Somatic Mutation;tumorigenesis;Untranslated RNA;Variant;whole genome;Work

PROJECT_TITLE: Selective pressures from inherited variation impacting myeloproliferative neoplasm initiation

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]