ADMINISTERING_IC: OD

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE. The Wisconsin National Primate Research Center (WNPRC) base operating grant supports services and resources for research addressing human health issues utilizing non-human primate (NHP) models. The WNPRC provides a rich and integrated portfolio of cutting-edge services, resources, and scientific expertise that support NHP research with high impact and direct relevance to human and animal health and disease. With ongoing additions to WNPRC infrastructure, and expansion of the Center’s scientific components and collaborations, the WNPRC is poised to advance the translation of NHP research findings into new remedies for some of our society’s most pressing medical problems.

PI_NAMEs: GREJNER-BRZEZINSKA, DOROTA A. (contact)

PROGRAM_OFFICER_NAME: BUHRING, BETTINA D

PROJECT_TERMS: Address;Animals;base;Biology;Biomedical Research;Collaborations;Communities;Disease;Doctor of Philosophy;Ecosystem;Funding;Grant;Health;Human;human disease;improved;Individual;Infrastructure;International;Knowledge;Medical;Midwestern United States;Mission;Modeling;Molecular;nonhuman primate;Prevention;Primates;programs;Quality of life;Research;Resources;Scientist;Services;Societies;Training;Translations;United States National Institutes of Health;Wisconsin

PROJECT_TITLE: Wisconsin National Primate Research Center Support


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PI_NAMEs: EHRT, SABINE  (contact)

PROJECT_TERMS: Affect;Aftercare;Agar;Alveolar Macrophages;B-Lymphocytes;Biological Markers;Biological Response Modifiers;Biotin;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;chemotherapy;Chronic;chronic infection;Clinical;Colony-forming units;Dexamethasone;Disease;disorder risk;Environment;Essential Genes;First Independent Research Support and Transition Awards;Genes;high risk;Human;Immune;Immunity;immunopathology;Immunophenotyping;Immunosuppression;in vivo;Infection;insight;Integration Host Factors;interstitial;Leukocytes;Ligase;Macrophage;Measures;Messenger RNA;Modeling;mouse model;Mouse Strains;Mus;mutant;Mycobacterium tuberculosis;Natural Killer Cells;Patients;Persons;Pharmacology;Physiological;Population;Predisposition;prevent;Proteins;Recommendation;Recurrent disease;Regulon;Relapse;relapse prediction;relapse risk;SCID Mice;Symptoms;T-Cell Depletion;T-Lymphocyte;Testing;thioredoxin reductase;Time;transcriptome;transcriptomics;Tuberculosis;tuberculosis chemotherapy

PROJECT_TITLE: Determinants of Paucibacillary Mtb Infection in Mice


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences;Patient Safety

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE There is a compelling need to find better alternatives to current general anesthetics, all of which produce undesirable effects and derive from pre-1980 molecular discoveries. This MIRA proposal aims to secure continued research support for the PI, a physician-scientist and international leader in research on general anesthetics whose innovative and rigorous work, long supported by NIGMS, aims to advance the field by defining receptor-based anesthetic mechanisms and by using zebrafish as a model to accelerate anesthetic discovery and mechanisms research. The PI also advances the NIH mission as a grant reviewer and director of a research training program (T32) for anesthesiologists.

PI_NAMEs: FORMAN, STUART A (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Acceleration;Address;Adopted;Affect;Agonist;Alcohols;Alphaxolone;Anesthetics;Animals;Area;Awareness;Barbiturates;Basic Science;Behavioral;Chemicals;Clinical;Conscious;Drug Interactions;Drug Receptors;Electrophysiology (science);Etomidate;Family;gamma-Aminobutyric Acid;General Anesthesia;General anesthetic drugs;Goals;Grant;hypnotic;improved;innovation;International;Intervention;Ion Channel Gating;Kinetics;Knock-in;Knock-out;Knowledge;Larva;Libraries;Ligands;Maps;Mediating;Medical;Membrane;Memory;Mission;Modeling;Molecular;Molecular Target;Motor;Mutation;National Institute of General Medical Sciences;Neural Inhibition;Neurophysiology - biologic function;neurosteroids;Nociception;Pharmaceutical Preparations;pharmacodynamic model;pharmacologic;Physicians;Proteins;receptor;Research;Research Support;Research Training;response;Role;Scientist;Secure;sedative;Site;Structure;Synapses;Testing;Time;tool;Toxic effect;Training Programs;Transgenic Organisms;Translational Research;United States National Institutes of Health;Work;Zebrafish

PROJECT_TITLE: Basic and Translational Research on General Anesthetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health; it will develop a novel approach to an HIV Cure by durably silencing and permanently inactivating viral expression. These results would have substantial benefit to the field because they would vertically advance understanding of the biology of HIV latency and provide tangible tools to eradicate HIV from people living with HIV. The project is relevant to NIH’s mission as it fulfills one of the high- priority topics of research for support using AIDS-designated funds, the research toward a Cure.

PI_NAMEs: NDHLOVU, LISHOMWA C;OTT, MELANIE MARIA (contact);VALENTE, SUSANA T

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Adopted;Africa;antiretroviral therapy;antiviral immunity;Architecture;base;base editor;Binding;Biology;Blood;Brazil;cell type;Cells;Cerebrospinal Fluid;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;collaboratory;combinatorial;Communication;Communities;Community Health Education;community partners;comorbidity;cortistatin;Dedications;Detection;DNA;Endogenous Retroviruses;Ensure;Epigenetic Process;Excision;expectation;Face;Failure;Foundations;Funding;Gene Silencing;Genome engineering;Gifts;Goals;Gut associated lymphoid tissue;Health;Health Services;HIV;HIV-1;Human;Human Genome;Immunosuppression;improved;Industry;industry partner;Infection;inhibitor;innovation;Intake;Integration Host Factors;integration site;latent HIV reservoir;Learning;Leukapheresis;life span;lymph nodes;member;Military Personnel;Mission;Molecular;Morbidity - disease rate;mortality;Mutation;Myeloid Cells;National Institute of Allergy and Infectious Disease;National Institute of Neurological Disorders and Stroke;next generation;novel;novel strategies;Obstruction;organizational structure;Peptide Nucleic Acids;Persons;Pharmaceutical Preparations;prevent;programs;Provirus Integration;Proviruses;Public Health;recombinase;Research;Research Personnel;Research Support;restoration;Risk;Sampling;San Francisco;Science;social stigma;Source;Stem cell transplant;success;Suggestion;Technology;Testing;Tissues;tool;Toxic effect;Translations;United States National Institutes of Health;Viral;Viral Load result;viral rebound;Viral reservoir;Virion;Virus;Virus Latency;Virus Replication;Work

PROJECT_TITLE: HOPE - HIV Obstruction by Programmed Epigenetics


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: IRVINE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative This project aims to develop new models for prediction of cognitive outcomes including cognitive change and incident Alzheimer’s disease. Prediction models will be developed by applying advanced machine learning techniques to high-dimensional data including clinical, neuropsychological, genetic, and biomarker data. This approach will lead to predictive tools that can be effectively used in research as well as clinical decision making for patients in prodromal stages of Alzheimer’s disease or individuals with normal cognition and high-risk of developing Alzheimer’s Disease.

PI_NAMEs: EZZATI, ALI  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Affect;aged;Aging;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease therapy;American;amyloid imaging;arm;Artificial Intelligence;Big Data;biological heterogeneity;Biological Markers;Biometry;career;career development;Classification;Clinical;clinical decision-making;clinical heterogeneity;clinical practice;Clinical Research;Clinical Trials;Cognition;Cognitive;Cognitive aging;cognitive change;cohort;comparative;Complex;computational neuroscience;cost;Data;Data Collection;data harmonization;data quality;Data Set;Data Sources;Decision Making;Dementia;demographics;Development;diagnostic accuracy;Dimensions;Disease;Disease Progression;Early Diagnosis;effective therapy;Elderly;Enrollment;Ensure;feature selection;follow-up;Foundations;functional decline;functional outcomes;Future;Genetic;Genetic Risk;global health;Goals;healthcare burden;high risk;Image;Impaired cognition;improved;Individual;innovation;International;Investigation;K-Series Research Career Programs;Life Style;Longitudinal cohort;Machine Learning;machine learning framework;machine learning method;machine learning model;machine learning prediction;Magnetic Resonance Imaging;Measurement;Measures;Mentors;Mentorship;Methodology;Methods;mild cognitive impairment;model generalizability;Modeling;multidimensional data;Neurobiology;Neurodegenerative Disorders;neuroimaging;Neurologist;Neurology;Neuropsychology;novel;Outcome;Participant;participant enrollment;patient oriented;Patients;Performance;Pharmaceutical Preparations;Population;pre-clinical;predict clinical outcome;Predictive Analytics;predictive modeling;predictive tools;Predictive Value;prevent;Prevention trial;Primary Prevention;prodromal Alzheimer's disease;prognostic;Research;Research Personnel;research study;risk prediction;Sample Size;Sampling;Secondary Prevention;Statistical Methods;structured data;success;Techniques;Therapeutic Effect;trial enrollment;United States;Universities;Washington;Work

PROJECT_TITLE: Predictive analytics for cognitive decline and Alzheimer's disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Declines in cognitive function and walking function are highly intertwined in older adults. A therapeutic approach that combines complex (cognitively engaging) aerobic walking exercise with non-invasive electrical brain stimulation may be effective at restoring lost function. This study tests whether electrical stimulation of prefrontal brain regions is more beneficial than sham stimulation.

PI_NAMEs: CLARK, DAVID J (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Adjuvant;Aerobic;Affect;Age;Age-associated memory impairment;Alzheimer's Disease;Alzheimer's disease related dementia;Behavior Therapy;Behavioral;behavioral outcome;Brain;Brain region;Cathodes;Clinical;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive task;cohort;combinatorial;Complex;Control Groups;density;design;dosage;efficacy evaluation;Electric Stimulation;Electrical Stimulation of the Brain;Enrollment;Esthesia;executive function;Exercise;experience;falls;frontal lobe;functional near infrared spectroscopy;functional restoration;improved;Intervention;Knowledge;machine learning algorithm;Magnetic Resonance Imaging;Measures;Mediation;Membrane Potentials;Modeling;Motor;multi-component intervention;Neuronal Plasticity;Neurons;neuroregulation;older adult;Outcome;Participant;Patient Self-Report;Performance;Persons;phase 1 study;phase 2 study;Pilot Projects;placebo group;Prefrontal Cortex;preservation;prevent;Procedures;Randomized;recruit;Research;Research Infrastructure;response;Risk Factors;Role;Safety;Site;supervised learning;Surface;Targeted Research;Testing;Therapeutic;transcranial direct current stimulation;treatment group;United States National Institutes of Health;Walking;walking program;walking speed;wearable device

PROJECT_TITLE: Cognitively engaging walking exercise and neuromodulation to enhance brain function in older adults

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome;Networking and Information Technology R&D (NITRD)

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

PHR: Project Narrative The proposed project will generate software tools that increase the ability of scientists to use genome sequence data to advance human health. This software enables creating central database repositories and websites contain- ing genome data and data on cellular networks for disease-causing bacteria such as Mycobacterium tuberculosis. The software will enable researchers to computationally detect cross-feeding relationships between bacteria within the human microbiome to develop a mechanistic understanding of the microbiome to advance health.

PI_NAMEs: KARP, PETER D (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Algorithmic Analysis;Algorithms;anti-microbial drug;Bacteria;Bacterial Genome;Bacterial Infections;base editing;Biochemical;Biochemical Pathway;Biochemical Reaction;Bioinformatics;Biological;Biology;cell growth regulation;central database;Chemicals;Choking;chronic inflammatory disease;cloud based;cofactor;Communication;Communities;comparative;Computer software;dashboard;Data;Data Analyses;Databases;Development;Disease;Disease Outbreaks;Documentation;Drug Design;Drug Targeting;Environment;Essential Genes;experimental study;feeding;Filler;Genbank;Gene Expression Profiling;gene product;Genes;Genome;genome database;Genome Mappings;genome-wide;Grant;gut microbiome;Health;Human;Human Microbiome;improved;Informatics;interest;International;Internet;Knowledge;Letters;Licensing;M. tuberculosis genome;Maintenance;member;Metabolic;Metabolic Pathway;metabolomics;metagenome;microbial community;microbial genome;microbiome;Mission;Modeling;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;next generation;Online Systems;operation;Operon;Organism;pathogen;pathogen genome;pathogenic bacteria;pathogenic Escherichia coli;Pathogenicity;Pathway Analysis;Pathway interactions;pathway tools;Procedures;Process;Production;Proteins;Publishing;Reaction;reconstruction;repository;Research;research and development;Research Personnel;response;RNA;Running;Scientist;Services;software systems;Software Tools;Speed;Structure;System;Systems Biology;tool;Training;transcriptome sequencing;Update;Vibrio cholerae;Visit;Visualization;web site;Work

PROJECT_TITLE: Development and Support of the Pathway Tools Software

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: EAST LANSING

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: NARRATIVE This project focuses on largely unexplored mechanisms that multicellular eukaryotes have evolved to grow and protect themselves from death and diseases caused by insufficiency and defects in secretory protein synthesis. To achieve our goals, we will harness the power of the genomic resources and molecular tools of the model plant species Arabidopsis thaliana, which allow genetic and advanced analyses that are impossible to perform in humans and whole-body mammalian models. By studying the signaling pathways of conserved sensors that monitor the homeostasis of secretory protein synthesis, this work will reveal new mechanisms that coordinate growth, stress responses and cell fate decisions and thus improve our understanding of human growth and disease.

PI_NAMEs: BRANDIZZI, FEDERICA  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Address;Biological;biological adaptation to stress;Biological Models;Body System;Cell Death;Cell Death Process;Cell Differentiation process;Cell Line;Cells;Cessation of life;Chronic;Defect;design;Diabetes Mellitus;Disease;Effector Cell;Endoplasmic Reticulum;endoplasmic reticulum stress;environmental stressor;Eukaryota;forward genetics;frontier;Genetic;genetic resource;Genetic Screening;genome resource;Goals;Growth;Homeostasis;Housekeeping;Human;improved;In Vitro;in vivo;Knowledge;Life;Link;Malignant Neoplasms;Medical;Membrane;misfolded protein;model organism;Modeling;Molecular;Monitor;Mouse-ear Cress;Nerve Degeneration;novel;Organism;Pathway interactions;Phosphorylation;Physiological;Plant Model;Plants;Production;Protein Biosynthesis;protein folding;Protein Kinase;Proteins;Research;Resistance;response;Ribonucleases;Role;secretory protein;sensor;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Stress;targeted treatment;therapeutically effective;tool;transcription factor;Work

PROJECT_TITLE: Unfolded protein response in the model species Arabidopsis thaliana

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: TALLAHASSEE

ORG_DEPT: BIOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: PROJECT NARRATIVE Guanylate-binding protein 2 (GBP2) is a major interferon-inducible GTPase that fights against microbial pathogens by disrupting their membranous replicative niche. Structural and mechanistic insights gleaned from this research will fill a major gap in the knowledge of pathogen detection and elimination by cell autonomous immunity and will shed light upon the design of new therapeutics for both infectious and autoinflammatory diseases.

PI_NAMEs: YIN, QIAN  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Address;analog;antimicrobial;Attention;autoinflammatory diseases;Bacteria;Bacteriolysis;Binding;Binding Proteins;Biochemical;Biological Assay;biophysical techniques;Biophysics;cell growth regulation;Cells;Communicable Diseases;Complex;Coupled;Coupling;Cryoelectron Microscopy;Crystallography;cytokine;Cytolysis;Data;design;Detection;Development;Dynamin;enzyme activity;Enzyme Kinetics;Exposure to;Extravasation;Family;farnesylation;fighting;Fluorescence;Glean;Goals;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;guanylate;Higher Order Chromatin Structure;Human;Hydrolysis;Immune;Immunity;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;insight;Interferon Type I;Interferon Type II;Interferons;Knowledge;Lead;Length;Light;light scattering;Lipids;Liposomes;Maps;Measures;Membrane;membrane model;microbial;Modeling;Molecular;Molecular Conformation;novel therapeutic intervention;novel therapeutics;Nucleotides;Parasites;pathogen;Pathogen detection;pathogen exposure;pathogenic microbe;Pattern recognition receptor;Play;Process;protein activation;Protein Activation Pathway;Proteins;prototype;reconstitution;recruit;Regulation;Research;Role;Rupture;Structure;System;Techniques;Toxoplasma gondii;unilamellar vesicle;Vacuole;Work;X-Ray Crystallography

PROJECT_TITLE: Mechanistic Insights into Activation and Regulation of Interferon-inducible GTPase GBP2

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ORG_CITY: PASADENA

ORG_DEPT: CHEMISTRY

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative! Accurate protein biogenesis is a pre-requisite for the generation and maintenance of a functional proteome, and is critical for preventing the onset of numerous diseases rooted in defective protein homeostasis. The proposed studies will advance our knowledge of the molecular and cellular mechanisms that ensure protein homeostasis within the cell, and contribute to the general understanding of physiology and pathology of eukaryotic cells at a fundamental level.

PI_NAMEs: SHAN, SHU-OU  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TITLE: Accurate Molecular Decision Making during Protein Biogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Contraception/Reproduction;Depression;Mental Health;Mental Illness;Prevention;Serious Mental Illness;Substance Misuse;Women's Health Research

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Alcohol use and misuse is rising in females, which makes it essential to identify female-specific risk factors for alcohol misuse. The proposed project will build a better understanding of cyclical changes in objective (heart rate variability) and subjective (self-reported) emotion regulation as a risk factor for cyclical alcohol misuse in females. By studying alcohol misuse changes across the most frequently-experienced reproductive sex steroid transition (i.e., the menstrual cycle), the results of this study will contribute critical information to NIAAA’s priorities for building a better understanding of alcohol misuse in females across the lifespan.

PI_NAMEs: PANG, RAINA  (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Address;alcohol consequences;Alcohol consumption;alcohol craving;alcohol misuse;alcohol relapse;alcohol risk;Alcohols;Awareness;Behavior;Behavioral Symptoms;clinically significant;coping;Data;Development;Dimensions;Distress;DSM-V;Ecological momentary assessment;emotion regulation;Emotional;emotional symptom;Emotions;Etiology;experience;Female;gender difference;Gonadal Steroid Hormones;Health;Heart Rate;heart rate variability;Heavy Drinking;high intensity drinking;Impairment;indexing;Individual;Individual Differences;individualized medicine;life span;Literature;Luteal Phase;male;Maps;Measures;Mediation;Menstrual cycle;Menstruation;Meta-Analysis;Mood Disorders;Motivation;National Institute on Alcohol Abuse and Alcoholism;Pathway interactions;Patient Self-Report;Periodicity;Peripheral;Persons;physical symptom;Physiological;Premenopause;premenstrual dysphoric disorder;Prevention strategy;Progesterone;prospective;Psychological reinforcement;Psychophysiology;recruit;Recurrence;reproductive;Research;response;Risk;Risk Factors;risk sharing;Sampling;screening;sensor;Severities;sex;Skin Temperature;Source;Strategic Planning;Symptoms;Testing;theories;United States National Institutes of Health;wearable sensor technology;Women's Health

PROJECT_TITLE: Cyclical deficits in emotion regulation as a risk factor for alcohol misuse in premenopausal females

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: DETROIT

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project Narrative Opioid use disorder (OUD) is a critical public health problem; however, the mechanisms underlying opioid use and relapse are still poorly understood. Stress is a clinically significant but experimentally understudied, correlate/predictor of drug motivation, use, and relapse. The proposed study will use neuromodulation via repetitive transcranial magnetic stimulation (rTMS), contrasted at two different, theoretically motivated frontal- cortical sites to examine mechanisms of pharmacological stress-induced opioid seeking in people with OUD and to explore potential targets for future interventions.

PI_NAMEs: MOSES, TABITHA EMILY HOWARD (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: acute stress;Address;Affective;alpha-amylase;Arousal;Attenuated;Basic Science;Behavior;Behavioral;biological adaptation to stress;Biological Markers;Biological Models;Brain;Brain imaging;Brain region;career;Cigarette Smoker;Clinical Research;clinical translation;clinically significant;Cognitive;cognitive function;Collaborations;craving;Data;design;Drug Modulation;drug seeking behavior;Drug usage;Electroencephalography;emotion dysregulation;Emotional;Event-Related Potentials;Executive Dysfunction;executive function;experience;Experimental Designs;FDA approved;Foundations;frontal lobe;Functional disorder;Future;Goals;Heart Rate;human subject;Hydrocortisone;Hyperactivity;Impairment;improved;improved outcome;indexing;Individual;innovation;Intervention;Knowledge;Learning;Left;Literature;Location;Major Depressive Disorder;Measurement;Measures;Medial;Mentorship;Methods;Modeling;Motivation;National Institute of Drug Abuse;negative affect;neural;neurobehavioral;neurobiological mechanism;Neurobiology;neuromechanism;neuropsychiatric disorder;neuroregulation;nicotine seeking behavior;Opioid;opioid use;opioid use disorder;Outcome;Participant;Pathway interactions;Pattern;Persons;Pharmaceutical Preparations;pharmacologic;Physicians;Placebos;Play;Prefrontal Cortex;Procedures;Protocols documentation;psychologic;Public Health;Publishing;Relapse;relapse risk;repetitive transcranial magnetic stimulation;Reproducibility;Research;response;reward circuitry;Rewards;Role;Scientist;Site;skills;Sorting;Stress;stress management;stress reactivity;stress reduction;stressor;Structure;substance use;Substance Use Disorder;Systems Theory;Techniques;theories;therapeutically effective;therapy development;tool;Training;training project;Treatment Protocols;Wisconsin;Work;Yohimbine

PROJECT_TITLE: Neuromodulation of stress-induced dysfunction and drug-seeking in opioid use disorder: comparison of fronto-cortical targets


ADMINISTERING_IC: DK

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: DOWNERS GROVE

ORG_NAME: MIDWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE Obesity is a major problem in the US, largely influenced by consumption of Western-style diets that modulate the gut microbiota. However, most research to date has emphasized bacteria within the gut, but has neglected to examine fungal communities. Thus, this project will investigate the impact of diet on the gut mycobiota and the specific effect of Candida on increasing fat absorption and obesity. This knowledge is expected to facilitate novel approaches targeting the gut mycobiome to increase quality of life and reduce health-care costs related to obesity.

PI_NAMEs: MARTINEZ-GURYN, KRISTINA BROOKE (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: 16S ribosomal RNA sequencing;absorption;Adult;Antibiotics;Bacteria;bacterial community;Binding;Biological Assay;BODIPY;Body Composition;Body Weight;C Type Lectin Receptors;Candida;Candida albicans;Carbohydrates;CD36 gene;Communities;Consumption;Data;Diabetes Mellitus;Diet;diet-induced obesity;Digestion;Disease;Epithelium;Esterification;Eukaryota;Fat-Restricted Diet;Fatty acid glycerol esters;Fatty Acids;feeding;Fluorescent in Situ Hybridization;fungal microbiota;fungus;gastrointestinal;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Germ-Free;Gnotobiotic;Goals;gut microbes;gut microbiome;gut microbiota;Health Care Costs;High Fat Diet;host-microbe interactions;Human;Impairment;In Vitro;innovation;Insulin Resistance;Intestines;jejunum;Knock-out;Knockout Mice;Knowledge;Length;Lipids;Literature;Macronutrients Nutrition;Mediating;member;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic Marker;Metabolism;Microbe;microbial;microbiome;microbiota;Molecular;Morphology;Mus;mycobiome;neglect;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Nutrient;Obese Mice;Obesity;obesity development;oral glucose tolerance;Organoids;Physiological Processes;Plasma;Play;Quality of life;Radiolabeled;receptor;Regulation;Research;response;Role;Saline;saturated fat;Shapes;Signal Transduction;Site;Small Intestines;small molecule;Stains;sugar;Supplementation;targeted treatment;Testing;therapeutic development;transcriptome sequencing;translocase;Up-Regulation;uptake;Weight Gain;western diet;Work;Yeasts

PROJECT_TITLE: The role of the gut mycobiota in regulating host lipid absorption and obesity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P(54)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Human Genome;Psoriasis;Rheumatoid Arthritis

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Systemic lupus erythematosus (lupus), rheumatoid arthritis, psoriasis, psoriatic arthritis and Sjogren’s syndrome are autoimmune diseases in which white blood cells produce inflammation in the kidneys (nephritis), joints (arthritis), skin (scaly patches) and glands (salivary in mouth and lacrimal in eyes (dry mouth and eyes), respectively. Current treatments for these diseases leave a large unmet need. By examining the cells of the involved tissues one cell at a time and learning which genes each cell expresses, we will identify new targets for drug development to treat these conditions.

PI_NAMEs: BRENNER, MICHAEL B. (contact);HACOHEN, NIR

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Arthritis;Autoimmune;Autoimmune Diseases;Autoimmunity;Automobile Driving;B-cell receptor repertoire sequencing;Biological;Biopsy;Blood;Blood specimen;Cell Nucleus;cell preparation;Cell Survival;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;cohort;Collaborations;Communication;Communities;computational pipelines;Computer Analysis;Consensus;Data;data pipeline;data quality;Data Set;design;Dimensions;Disease;disorder subtype;Dissociation;drug development;experience;Eye;eye dryness;flexibility;Freezing;gene product;Genes;Genomics;Gland;Goals;high dimensionality;Human Resources;Image;Industry;industry partner;Inflammation;Infrastructure;Joints;Kidney;lacrimal;Learning;Leukocytes;Lip structure;Lupus;Methods;Minor salivary gland structure;Modification;Molecular;Morphologic artifacts;multidimensional data;Nephritis;new therapeutic target;novel therapeutic intervention;Nuclear;Oral cavity;Organ;Pathology;Pathway interactions;Patients;peripheral blood;Phase;Pilot Projects;Preparation;preservation;Proteomics;Protocols documentation;Psoriasis;Psoriatic Arthritis;reconstruction;recruit;Research Personnel;Rheumatoid Arthritis;Running;Salivary;Sampling;scale up;single cell analysis;single cell genomics;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;Sjogren's Syndrome;Skin;Specimen;Suggestion;Synovial Membrane;Systemic Lupus Erythematosus;Systems Biology;Technical Expertise;Technology;Testing;Time;tissue preparation;Tissue Preservation;tissue processing;Tissue Sample;Tissues;Transcript;transcriptomics;United States National Institutes of Health;Urine;Vision;Work;Xerostomia

PROJECT_TITLE: Single cell and spatial genomic analyses of specimens from patients with autoimmune diseases (Technology Core)


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Narrative The development of high-throughput genomic technology has transformed biomedical sciences and provides limitless potential for developing new treatments for disease. However, analyzing the data generated by these technologies requires tremendous computational resources and significant computational expertise by the researchers. The education program described in this proposal is a program designed to train the next generation of biomedical researchers and provide them mentoring to support their careers in biomedical research.

PI_NAMEs: ESKIN, ELEAZAR  (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Area;Biomedical Research;California;career;Career Mobility;Collaborations;Communities;Computing Methodologies;computing resources;curriculum development;Data;design;Development;Disease;Education;effectiveness measure;Evaluation;Exposure to;Faculty;faculty mentor;faculty support;Funding;Genomics;Goals;graduate student;innovation;Institution;Knowledge;Learning;lectures;Letters;Los Angeles;Mentors;method development;Methodology;Methods;Minority-Serving Institution;National Institute of General Medical Sciences;next generation;Organizational Objectives;outreach;outreach program;Participant;Periodicals;Positioning Attribute;Postdoctoral Fellow;Program Description;Program Development;programs;Reproducibility;Research;Research Personnel;Science;Series;skills;Students;success;summer institute;summer program;Surveys;Techniques;Technology;Time;Training;Travel;Underrepresented Populations;Universities

PROJECT_TITLE: Computational Genomics Summer Institute and Mentoring Network


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: SANTA CRUZ

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: PROJECT NARRATIVE Respiratory syncytial virus (RSV) is the top cause of severe lower respiratory tract disease in young children worldwide. This proposal seeks to use atomic-level structural information on the RSV G protein to rationally engineer it as an effective vaccine antigen that protects against RSV infection and disease.

PI_NAMEs: DUBOIS, REBECCA MICHELLE (contact);TRIPP, RALPH A

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: Affect;Affinity;airway epithelium;Antibodies;Antibody Response;Antigens;Binding;Body Weight decreased;Cells;Cellular Infiltration;Child;CX3CL1 gene;cytokine;design;Disease;Elderly;Electron Microscopy;Engineering;Epithelial Cells;Epitopes;Essential Amino Acids;Evaluation;functional status;Funding;glycosylation;Goals;GTP-Binding Proteins;Human;human monoclonal antibodies;Immune;Immune response;Immunity;Immunization;Immunocompromised Host;immunogenic;immunogenicity;Immunology;improved;Inbred BALB C Mice;Infant;insight;interdisciplinary approach;Leukocytes;Lower respiratory tract structure;Lung;Measurement;Molecular Conformation;Morbidity - disease rate;mortality;Mus;mutant;Mutation;Negative Staining;novel;Pathogenesis;pathogenic virus;Pathway interactions;Phenotype;Positioning Attribute;preservation;prevent;protein complex;Protein Engineering;protein oligomer;protein structure;Proteins;Pulmonary Pathology;rational design;Research;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Syncytial Virus Vaccines;Respiratory Tract Diseases;response;Safety;Serum;Severity of illness;Structure;Surface;Testing;three dimensional structure;Vaccinated;Vaccination;Vaccine Antigen;Vaccine Research;Vaccines;Viral Load result;Viral Pathogenesis;Viral Physiology;Viral Respiratory Tract Infection;virology;Virus;Virus Diseases;X-Ray Crystallography

PROJECT_TITLE: Structure-guided engineering to increase respiratory syncytial virus G protein immunogenicity

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: NARRATIVE DNA sequences can form structures that are “difficult-to-replicate,” which can serve as barriers to DNA replication and repair and lead to genome instability and cancer. Our proposal is designed to characterize the role of DNA2/MutSα complex in overcoming specific difficult-to-replicate structures, called G-quadruplexes, during DNA replication or repair. Our results will define the cellular pathways and molecular mechanisms involved in overcoming G-quadruplexes, will affirm that individuals with defects in these pathways are more susceptible to cancer, and will provide a solid foundation for new cancer treatment regimens.

PI_NAMEs: SHEN, BINGHUI  (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Aflatoxin B1;Binding;Binding Proteins;Biological;Cancer Biology;cancer cell;Cancer Etiology;cancer initiation;cancer therapy;Cells;Centromere;Chemical Exposure;Chemicals;Chromosomes;Complex;Defect;design;Development;DNA;DNA biosynthesis;DNA Double Strand Break;DNA Mismatch Repair Protein MSH2;DNA Repair;DNA replication fork;DNA Sequence;DNA Sequence Alteration;DNA Structure;Double Strand Break Repair;Elements;Environment;Environmental Risk Factor;Epigenetic Process;Excision;Excision Repair;Foundations;Funding;G-Quartets;Gene Expression;Gene Mutation;Genetic;Genome;Genomic Instability;Goals;helicase;Histones;Human;Impairment;In Vitro;Individual;Knowledge;Malignant Neoplasms;Mammalian Cell;Mediating;Microsatellite Repeats;Minisatellite Repeats;Modeling;Molecular;Movement;MSH2 gene;MSH6 gene;Mus;novel;Nuclear;nuclease;Pathway interactions;Phenotype;Pigments;Predisposition;Process;protoporphyrin IX;Radiation;recruit;repaired;replication stress;Resolution;response;RNA;Role;S phase;Signal Transduction;Single-Stranded DNA;Site;Solid;Source;Structure;synergism;Tail;telomere;Treatment Protocols;tumor progression;tumorigenesis;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Dynamic functions of DNA2 counteract DNA replication stresses and tumorigenesis

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ORG_DEPT: PHARMACOLOGY

PHR: Narrative Despite the fact that steroid hormone receptors (SRs) are the most targeted proteins in medicine for a wide variety of conditions, development of next generation tissue or cell-selective drugs is limited by lack of high- resolution 3D structures. To fully understand SR biology and therapeutic opportunities requires structure analyses of the native state full-length receptor and associated coregulatory proteins as a complex on target DNA and to determine how protein interactions modulate the conformation and activity of SRs. The overall goal of the project is to fill this major gap in our knowledge.

PI_NAMEs: EDWARDS, DEAN P;GRIFFIN, PATRICK ROBERT (contact);KUMAR, RAJ

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: 3-Dimensional;Affect;Agonist;Attenuated;base;Binding;Biological Assay;Biology;Cells;Classification;Clinical;Complex;Coupled;crosslink;Crosslinker;Cryoelectron Microscopy;Data;data exchange;detector;Deuterium;Development;DNA;DNA receptor;Drug Interactions;Electrons;Environment;EP300 gene;Exhibits;experimental study;flexibility;Gene Activation;Genes;Genetic Transcription;Goals;Heterogeneity;Hydrogen;Image;image processing;insight;Kinetics;Knowledge;Length;Ligands;Link;Macromolecular Complexes;Maps;Mass Spectrum Analysis;Measures;Mediating;Medicine;Modeling;Molecular Conformation;Mutagenesis;Mutate;Mutation;N-terminal;nanometer resolution;NCOA3 gene;Negative Staining;next generation;Normal tissue morphology;novel;Nuclear;Outcome;Pathologic;Pharmaceutical Preparations;Phase;Physiological;Process;progesterone receptor A;progesterone receptor B;Progesterone Receptors;Progestins;protein complex;Protein Hormone Receptor;Protein Isoforms;Proteins;receptor;reconstruction;Reporting;Resolution;response;Response Elements;Role;RXR;screening;steroid hormone receptor;Structural Models;Structure;Surface;Techniques;Therapeutic;three dimensional structure;Tissues;tool;Transactivation;Transcription Coactivator;transcription factor;X-Ray Crystallography

PROJECT_TITLE: Structural dynamics of progesterone receptor-coactivator complexes

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: BETHESDA

ORG_NAME: AMERICAN GASTROENTEROLOGICAL ASSN/INST

ORG_STATE: MD

PHR: PROJECT NARRATIVE Fecal microbiota transplantation (FMT) is an established treatment for patients with recurrent Clostridioides difficile infection (CDI), but its role in treating acutely ill patients with severe or fulminant CDI is uncertain. Important safety concerns also remain around FMT, including the potential for transmission of harmful microorganisms or possible development of chronic conditions such as diabetes or heart disease due to changes in gut microbes resulting from FMT. This research will help determine if FMT has a role in the treatment of acutely ill hospitalized patients with severe or fulminant CDI, assess techniques to identify potentially harmful microorganisms that may be transmitted by FMT, and see if chronic conditions develop more commonly years after FMT.

PI_NAMEs: KELLY, COLLEEN RENEE;LAINE, LOREN A.;WU, GARY D. (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acute;Address;American;Animal Model;Bacteria;biobank;Biological Response Modifier Therapy;Biometry;Case Study;Childhood;Chronic;Clinical;Clinical Data;Clinical effectiveness;clinical practice;Clostridium difficile;Colectomy;Colitis;Collection;Communicable Diseases;comparative effectiveness;comparative safety;Control Groups;COVID-19 pandemic;Crohn's disease;Data;Data Analytics;Databases;Development;Diabetes Mellitus;Donor person;Donor Selection;Effectiveness;effectiveness evaluation;Eligibility Determination;emerging pathogen;Enrollment;enteropathogenic Escherichia coli;Escherichia coli EHEC;Evaluation;Event;experimental study;FDA approved;fecal transplantation;Feces;Feedback;Formulation;Foundations;Gastroenterology;genome sequencing;Genotype;Goals;gut microbes;gut microbiota;Heart Diseases;Hepatology;high risk population;Hospitalization;Human;Human Microbiome;in vitro Bioassay;Incidence;Infection;Infrastructure;Infusion procedures;Investigation;Knowledge;Link;Malignant Neoplasms;Marketing;Medical;Metadata;metagenomic sequencing;Microbe;microorganism;Morbidity - disease rate;mortality;multi-drug resistant pathogen;mycobiome;next generation;North America;nutrition;Obesity;off-label use;Participant;participant enrollment;Pathogenesis;pathogenic bacteria;Patients;Phase II/III Trial;Phenotype;Population;Practice Guidelines;prototype;Provider;randomized trial;Recurrence;recurrence prevention;Registries;Reporting;Research;resistome;Resources;Risk;Role;Safety;Scientific Advances and Accomplishments;Sensitivity and Specificity;Shotguns;Site;Societies;Source;Structure;Techniques;technology platform;Time;transmission process;Transplant Recipients;virome;virulence gene;whole genome;Work

PROJECT_TITLE: Fecal Microbiota Transplant National Registry


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: Houston

ORG_NAME: ACCEL DIAGNOSTICS, LLC

ORG_STATE: TX

PHR: Narrative Responding to the COVID-19 emergency, Accel Diagnostics is developing an inexpensive, easy to use, rapid, and quantitative anti-COVID-19 antibody test, RapidQCT™ - The first fully disposable quantitative blood test, the size of credit card, which require only one drop of blood from finger prick to quantify the COVID-19 antibody titer (concentration), and help monitoring the spreading of the disease and the individual and herd immunity.

PI_NAMEs: GANDINI, ALBERTO  (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;acquired immunity;Age;Antibodies;antibody test;Antibody titer measurement;Biological Assay;Blood;Blood Tests;Calibration;Chickenpox;Clinical;Collaborations;Companions;cost;COVID-19;COVID-19 monitoring;COVID-19 pandemic;COVID-19 point of care;COVID-19 vaccine;Data;design;Development;Devices;Diagnosis;Diagnostic;Disease;Disease Progression;Drops;Emergency Situation;Enrollment;Ensure;expectation;fabrication;Fetal Development;Fingers;Funding;Funding Mechanisms;Gender;Hand;health management;Health Personnel;Health protection;Health Sciences;Hearing;Hepatitis B;Herd Immunity;Immune system;Immunity;Immunocompetence;Immunoglobulin G;Immunoglobulin M;Immunologics;Individual;Infection;Institutional Review Boards;Lateral;Legal patent;Licensing;manufacture;Marketing;maternal immune system;Measles;Medicine;mHealth;microfluidic technology;mobile application;Molecular;Monitor;novel;Nucleic Acid Amplification Tests;Outcome;pandemic disease;Patients;Persons;Phase;Physicians;Play;point of care;Population;pre-clinical;Pregnancy;Process;Protocols documentation;prototype;rapid test;Readiness;Reagent;Recommendation;Reproducibility;response;Rubella;Sample Size;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 infection;SARS-CoV-2 positive;scale up;Secondary Immunization;Secure;Self Administration;Serology;Serology test;Severities;Societies;Specificity;Statistical Data Interpretation;Symptoms;Technology;Test Result;Testing;Texas;Thinness;Time;Time trend;tool;Translating;trend;Universities;Vaccination;vaccination strategy;Validation;Viral Proteins;Virus;Virus Diseases

PROJECT_TITLE: A COVID-19 Point of Care Serological Assay for Rapid Quantification of Antibody Titer.


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Small vessel disease (SVD) of the brain is a leading cause of stroke and disability, including vascular cognitive impairment and dementia (VCID). By using a set of advanced optical imaging tools and a clinically relevant mouse model of the most common monogenic inherited form of SVD, CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), we will elucidate the mechanisms of microvascular dysfunction and the missing link between small vessel dysfunction and their capacity to provide adequate brain tissue oxygenation. We hope that this work will fill significant gaps in our understanding of the mechanisms and consequences of microvascular dysfunction in CADASIL, and inform about the vascular mechanisms of progressive neurodegeneration and cognitive impairment in more common forms of SVD as well as in Alzheimer’s disease and related dementias.

PI_NAMEs: AYATA, CENK ;SAKADZIC, SAVA  (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: age related;Alzheimer's disease related dementia;Amyloid;Animal Genetics;Animal Model;Antibodies;Area;Arterial Disorder;arteriole;autosome;awake;Blood capillaries;Blood flow;Blood Vessels;Brain;Brain Diseases;Brain region;brain tissue;Cerebral small vessel disease;Cerebrovascular Circulation;Cerebrum;Clinical;clinically relevant;Cortical vasculature;Data;Dementia;Diffusion;disability;Disease;DTR gene;EGF gene;Epidermal Growth Factor Receptor;Equilibrium;Erythrocytes;Exhibits;Functional disorder;Genetic;gray matter;hemodynamics;Heterogeneity;human disease;human model;Hyperemia;Hypertension;Hypoxia;Imaging Device;Immunologics;Impaired cognition;Impairment;Inherited;innovative technologies;insight;islet;Knowledge;Link;Maps;Measurement;Measures;metabolic rate;Microscopy;Microvascular Dysfunction;Modeling;Molecular;Morphology;mouse model;multimodality;Mus;mutant;Mutation;NOTCH3 gene;novel;novel imaging technology;Optical Coherence Tomography;optical imaging;Optics;Oxygen;Passive Immunization;Pathway interactions;Perfusion;Pericytes;pharmacologic;progressive neurodegeneration;Publishing;Research;Resolution;response;Rest;Signal Transduction;Smooth Muscle Myocytes;Stroke;Structural defect;Subcortical Infarctions;Subcortical Leukoencephalopathy;Testing;therapy development;Time;TIMP3 gene;tissue degeneration;tissue oxygenation;Tissues;tool;Transgenic Mice;Transgenic Model;Trees;two photon microscopy;vascular cognitive impairment and dementia;Vascular Smooth Muscle;Visualization;white matter;Work

PROJECT_TITLE: Investigating the Microvascular Mechanisms of O2 Supply-Demand Mismatch in Small Vessel Disease using Novel High-Resolution Optical Imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-E(03)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PHOENIX

ORG_NAME: BANNER HEALTH

ORG_STATE: AZ

PHR: NARRATIVE We will develop, use, and extensively share two critically important resources of cognitive, biomarker, genetic, and related data from cognitively unimpaired 50-90-year-old persons with each common form of APOE, the major AD susceptibility gene, representing six levels of risk. We will clarify the impact of APOE, other genetic and non-genetic factors, and their interactions on the predisposition to, protection from and potential prevention of AD, inform the design and size of 12 or 24-month prevention trials using biological outcome measurements, and demonstrate the value of extremely promising blood tests in these endeavors. We will provide an extensively shared resource of data, findings, biological samples, and motivated APOE-tested volunteers for the research community, support a wide range of other studies, and increase the chance that our Alzheimer's Prevention Initiative (API) will help find and support the accelerated approval of AD prevention therapies before 2025.

PI_NAMEs: ASHTON, NICHOLAS ;LANGBAUM, JESSICA BROOKE;REIMAN, ERIC MICHAEL (contact);SU, YI ;WOODRUFF, BRYAN K

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Acceleration;Affect;Age;age stratification;Age Years;Alleles;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-42;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-4;Arizona;autosome;Binding;Biological;Biological Markers;Blood;Blood Pressure;Blood Tests;blood-based biomarker;Brain imaging;Clinical;Clinical Data;Cognitive;cohort;Communities;Complement;Data;Data Analyses;data anonymization;data resource;data sharing networks;design;Detection;Development;DNA;Dose;Education;endophenotype;Enrollment;Evaluation;Foundations;Functional disorder;Future;Gene Silencing;Genetic;genetic resource;Genetic Risk;Genotype;Heparan Sulfate Proteoglycan;Heterozygote;Homozygote;human old age (65+);Image;indexing;Inflammation;interest;Latino;Life Style;Light;Measurement;Mutation;Nerve Degeneration;neurofilament;Neuronal Injury;non-genetic;novel;Older Population;Other Genetics;Outcome;Participant;Persons;Plasma;polygenic risk score;pre-clinical;Predisposition;Prevention;prevention evaluation;Prevention therapy;Prevention trial;Productivity;programs;protective factors;rare variant;Research;Residual state;Resource Sharing;Resources;Risk;Risk Factors;Role;Sampling;Secondary Prevention;Senile Plaques;sex;Specimen;Surrogate Endpoint;Susceptibility Gene;tau Proteins;Testing;Therapeutic;Update;Variant;volunteer

PROJECT_TITLE: APOE in the Predisposition to, Protection from and Prevention of Alzheimer's Disease


ADMINISTERING_IC: HD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Genetics;Human Genome;Infertility;Pediatric;Pregnancy;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_DEPT: VETERINARY SCIENCES

PHR: The proposed studies will conduct a systematic, comparative study on trophoblast from mice and bovine embryos, as well as human trophoblast cell culture models, focusing on a novel mechanism in trophoblast formation and gene expression. The proposed project has the potential to revolutionize our understanding of the molecular basis of early embryonic loss and clinical reproductive disorders that are associated with abnormal placentation.

PI_NAMEs: JIANG, ZONGLIANG  (contact);XIAO, ZHUO ANDREW

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Abnormal placentation;Address;Adenine;Alleles;Biology;blastocyst;cancer cell;Cattle;Cell Culture Techniques;Cell Lineage;Cells;Clinical;Communication;comparative;Comparative Study;Complex;conditional knockout;Defect;demethylation;Development;DNA Methylation;Elements;Embryo;embryo culture;Embryo Loss;Embryonic Development;Enhancers;Ensure;Epigenetic Process;epigenetic regulation;Experimental Models;Failure;failure Implantation;Fetal Growth Retardation;Fetus;Gene Expression;Gene Targeting;Genes;Genetic;Genetic Transcription;Genomics;Human;Human Genome;human pluripotent stem cell;human stem cell-derived;human stem cells;Hypoxia;Impairment;imprint;improved;in utero;In Vitro;in vivo;innovation;insight;interest;Invaded;Knock-out;Knockout Mice;Laboratories;Locus Control Region;mammalian genome;Mammals;Maps;Modeling;Modification;Molecular;Mothers;mouse model;Mus;natural Blastocyst Implantation;Nature;novel;Nucleic Acid Regulatory Sequences;overexpression;Pathology;Physiological;Placenta;placental trophoblasts;Placentation;Play;Pluripotent Stem Cells;Positioning Attribute;Pre-Eclampsia;Pre-implantation Embryo Development;Probability;Regulatory Element;reproductive system disorder;Research;response;Role;Signal Pathway;Single Nucleotide Polymorphism;somatic cell nuclear transfer;Specific qualifier value;Spontaneous abortion;stem cell differentiation;stem cell model;stem cell self renewal;Study models;Testing;trophoblast;trophoblast stem cell;Uterus;Work

PROJECT_TITLE: DNA Methylation at N6-Adenine in Placental Trophoblast Development

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Genetics;Kidney Disease

ORG_CITY: SALT LAKE CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: We propose to use the newly developed small molecule KH-3 to evaluate HuR-targeted therapeutics for inhibition of renal inflammation and subsequent renal fibrosis by using animal models that resemble chronic kidney disease (CKD) in many ways seen in human patients. Successfully carried out, these results will serve as an important basis for translation into the clinical setting with improved potential for patient care for those living with, or at the risk of, progressive CKD.

PI_NAMEs: HUANG, YUFENG  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Adjuvant Therapy;Affect;Angiotensin II;Animal Model;Animals;Antibodies;Antigens;Attenuated;Binding Proteins;Biodistribution;Biological Assay;Biological Markers;biomarker identification;Cell Line;Cell Physiology;Cell Survival;Cells;Chronic;Chronic Kidney Failure;Clinical;Companions;cytokine;cytotoxicity;Data;Development;Diabetic Nephropathy;Disease;disease model;Disease Progression;Disease remission;DOCA;Dose;Drug Kinetics;End stage renal failure;Exhibits;experimental study;Fibrosis;Future;Genes;Glomerular Mesangial Cell;Glomerulonephritis;glomerulosclerosis;Goals;Growth;Healthcare;high throughput screening;Human;Hypertension;Immune response;Immunoprecipitation;improved;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;Injections;Injury;Injury to Kidney;Innovative Therapy;Ischemia;Kidney;kidney cell;Kidney Diseases;Kidney Failure;kidney fibrosis;knock-down;Lead;lead optimization;Malignant Neoplasms;Maximum Tolerated Dose;Mediating;Mediator;Messenger RNA;Metabolism;Methods;Modeling;Monitor;mRNA Stability;mRNA Translation;Nephritis;novel;novel therapeutic intervention;Outcome;overexpression;Patient Care;Patient Selection;Patients;Prevalence;Proteins;Proteinuria;Rattus;Reaction;Renal function;Renal glomerular disease;Renal Tissue;Reperfusion Therapy;response;Ribonucleoproteins;Risk;RNA-Binding Proteins;Route;Safety;Schedule;Series;small hairpin RNA;small molecule;targeted biomarker;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Tissues;transcriptome sequencing;Transforming Growth Factor beta;Translations;treatment strategy;Tubular formation;Validation

PROJECT_TITLE: Novel therapeutic strategy for renal fibrosis by targeting RNA-binding protein HuR


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurosciences;Prevention;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Despite the success of antiretroviral therapy (ART) in decreasing mortality for HIV-1-infected patients, ART has not cured the disease. A persistent viral reservoir in the T cells of HIV patients receiving potent ART is a significant barrier preventing an HIV cure. Including scientists from leading universities and Merck Research Laboratories, Qura Therapeutics, Emmune, ViiV Healthcare and Macrogenics, the Collaboratory of AIDS Researchers for Eradication (CARE) will develop and testing therapies that will destroy the viral reservoir and allow ART-free remission.

PI_NAMEs: MARGOLIS, DAVID M. (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affinity;Animal Model;Antibodies;antibody-dependent cell cytotoxicity;antiretroviral therapy;Area;Back;Binding;Biological;Biological Assay;Biological Models;Biology;Bispecific Antibodies;candidate selection;CD4 Positive T Lymphocytes;Cells;Cellular biology;chimeric antigen receptor T cells;Chromatin;chromatin remodeling;chronic infection;Clinical;clinical development;Clinical Trials;collaboratory;Communities;Complex;Dedications;design;Development;Disabling;Disease;Disease remission;Engineering;Environment;Experimental Animal Model;experimental study;Funding Mechanisms;Generations;Genetic Transcription;Genome;Goals;Government;Healthcare;HIV;HIV Entry Inhibitors;HIV Infections;HIV-1;Human;humanized mouse;improved;in vivo;Industry;industry partner;Infection;Infrastructure;insight;Interruption;Intervention;Laboratory Research;latent infection;Lead;Lymphoid;Macaca mulatta;Measures;Methods;mimetics;Mission;Modality;Monoclonal Antibodies;mortality;mouse model;Mus;Myelogenous;Myeloid Cells;neonatal Fc receptor;next generation;NF-kappa B;nonhuman primate;novel;novel strategies;Patients;Peptides;peptidomimetics;Pharmaceutical Preparations;pre-clinical;preclinical study;prevent;Prevention;Process;programs;Proviruses;receptor;reconstitution;Regulation;Research;Research Personnel;Residual state;response;Science;Scientist;Signal Transduction;SIV;small molecule;Speed;success;sulfotransferase;System;T-Cell Receptor;T-Lymphocyte;Technology;Testing;Therapeutic;Time;Tissues;tool;Universities;Validation;Viral;Viral Antigens;Viral Proteins;viral rebound;Viral reservoir;Viremia;Work


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Biotechnology;Data Science;Genetics;Human Genome;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative 6 million children in the US suffer from asthma, and the likelihood that any child will develop asthma depends heavily on their genetic and epigenetic regulations. My statistical machine learning models will identify new genetic and epigenetic risk factors that are associated with childhood asthma by regulating the expression of disease-causing or disease-preventing genes. This knowledge will help to advance precision medicine approaches to treating childhood asthma.

PI_NAMEs: KIM, SOYEON  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Affect;Asthma;asthmatic;Award;Bioinformatics;Biological;biomarker identification;Child;Childhood;Childhood Asthma;CISH gene;Classification;clinical care;clinical center;Data;differential expression;Disease;Distant;DNA;DNA Methylation;Doctor of Philosophy;Education;Environment;Environmental Risk Factor;Epigenetic Process;epigenetic regulation;epigenome-wide association studies;Extrinsic asthma;Floor;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;genome wide association study;Goals;Grant;Health Care Costs;Journals;Knowledge;Laboratories;learning strategy;machine learning method;machine learning model;Malignant neoplasm of lung;Manuscripts;Measures;Mediation;medical schools;Mentors;Methylation;Modeling;Molecular Abnormality;Morbidity - disease rate;Multiomic Data;Nasal Epithelium;Nature;novel;novel therapeutics;Outcome;Pathogenesis;Pediatric Hospitals;Play;Postdoctoral Fellow;precision medicine;prevent;Puerto Rican;Quality of life;Regulation;Research;Rice;Risk Factors;RNA;Role;Single Nucleotide Polymorphism;Source;statistical and machine learning;statistical learning;Statistical Methods;statistics;Supercomputing;symposium;targeted treatment;Testing;Transcript;Universities;Work

PROJECT_TITLE: Identifying Genetic and Epigenetic Risk Factors Regulating Gene Expression for Childhood Asthma

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Dietary Supplements;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Prevention;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Young women’s breast cancer is a particularly deadly disease, and biology related to weaning is the likely cause. With weaning, changes occur in the breast that are very similar to a healing wound and cause increased incidence of metastatic breast cancer in rodent models. The purpose of this research is to test the ability of ibuprofen and vitamin D to prevent these deadly postpartum breast cancers, using relevant rodent models and a unique collection of normal human breast tissue obtained from women during the lactation/weaning cycle.

PI_NAMEs: SCHEDIN, PEPPER J (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Accounting;Age;Anti-Inflammatory Agents;anticancer activity;arm;Autoimmune;Biology;Breast;breast cancer diagnosis;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Prevention;Breast Cancer Prevention Trial;Breast Epithelial Cells;cancer chemoprevention;cancer invasiveness;CD8-Positive T-Lymphocytes;Cell Death;Characteristics;Chemoprevention;Child;Clinical;Collection;cost;Cytotoxic T-Lymphocytes;Data;Deposition;Diagnosis;Disease;early onset;Event;Exhibits;Extracellular Matrix;Fibroblasts;Foundations;Functional disorder;Gland;Goals;high risk;High Risk Woman;Hot Spot;Human;Ibuprofen;Immune;immune cell infiltrate;Immune system;Immune Tolerance;Immunologic Surveillance;immunoregulation;improved;improved outcome;Incidence;Infiltration;Inflammatory;Intervention;ITGAM gene;Lactation;Life;Lymphangiogenesis;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;Mammary gland;Mammary Gland Parenchyma;Mammary Neoplasms;Metastatic breast cancer;Modeling;mouse model;Myeloid-derived suppressor cells;Neoplasm Metastasis;Neoplasm Transplantation;Non-Steroidal Anti-Inflammatory Agents;Noninfiltrating Intraductal Carcinoma;novel;Nulliparity;Nurses;Outcome;Pathway interactions;Patients;Phenotype;Physiological;pill;Play;postnatal;postpartum breast cancer;Postpartum Period;Postpartum Women;pre-clinical;Pregnancy;pregnant;prevent;Prevention strategy;Preventive;Probability;Process;Prognosis;protective effect;Reaction;Regulatory T-Lymphocyte;reproductive;Research;Risk;risk prediction;Rodent;Rodent Model;Role;Safety;safety and feasibility;Secondary Cancer Prevention;Secondary Prevention;T-Lymphocyte;Testing;timeline;Tissues;Translating;transplant model;tumor;Tumor Immunity;tumor microenvironment;Tumor Tissue;tumorigenic;Vitamin D;Vitamin D Deficiency;Vitamin D supplementation;volunteer;Weaning;Woman;women's outcomes;women's prevention;Work;wound healing;young woman

PROJECT_TITLE: NSAIDs During Postpartum Involution for Breast Cancer Chemoprevention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-K(03)M]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative The core pillars of this project are aimed at increasing our understanding of mammalian consumption behavior, the rejection of toxins, and the principles of sensory coding. As such, the work is directly related to improving human health in this era of obesity and binge-eating. Using electrophysiology in freely moving and consuming animals, along with pioneering computational techniques, I will examine the influence that the main feeding region, the lateral hypothalamus, has on cortical taste processing and behavior, paving the way for future research on intervention in disorders relating to hedonics and consumption.

PI_NAMEs: MAIGLER, KATHLEEN C (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TITLE: The contribution of lateral hypothalamus to cortical palatability coding and behavior


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Mendelian conditions, which include diseases, but also include phenotypic differences that may not be considered a “disease,” are caused mainly by mutations in the protein-coding regions of the genome. Although the genes underlying thousands of Mendelian phenotypes have been identified, there are thousands of Mendelian conditions for which the gene(s) remain to be discovered. We propose to use an extensive network of clinicians and investigators, next generation sequencing coupled with new analytical paradigms, and technological innovations to efficiently discover novel genes for as many Mendelian conditions as possible.

PI_NAMEs: BAMSHAD, MICHAEL JOSEPH;EICHLER, EVAN ;WEI, CHIA-LIN  (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Acceleration;advocacy organizations;analytical tool;Clinical;clinical care;ClinVar;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;Collaborations;Communities;Congenital Abnormality;Coniferophyta;cost effective;Country;Coupled;CRISPR interference;Data;Data Coordinating Center;data sharing;database of Genotypes and Phenotypes;Deposition;design;Development;Diagnostic;Diagnostic tests;Disease;disease-causing mutation;empowerment;exome;exome sequencing;Family;follow-up;FURIN gene;gene discovery;Gene Expression;Genes;Genetic;genetic architecture;Genome;genome editing;genome sequencing;genome wide methylation;Genomics;Genotype;Goals;high throughput screening;Human Genetics;Individual;Industry;innovation;Institution;Knowledge;Leadership;Link;Medical;Medical Genetics;Metadata;Methodology;Methods;Mutation;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;next generation sequencing;novel;novel strategies;open data;Open Reading Frames;Pathogenicity;Phenotype;phenotypic data;programs;Publishing;rare condition;Rare Diseases;Reporting;repository;Research;Research Personnel;Resources;RNA Splicing;Role;Sampling;success;technological innovation;Technology;Testing;tool;transcriptome sequencing;Translations;United States National Institutes of Health;Universities;Untranslated RNA;Validation;Variant;variant detection;Washington;web platform;whole genome;Work

PROJECT_TITLE: University of Washington Mendelian Genomics Research Center (UW-MGRC)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_DEPT: PSYCHOLOGY

PHR: PROJECT NARRATIVE Alcohol dependence and multiple withdrawal experiences are related to increased severity of alcohol use disorder, craving, and resistance to treatment. Studies proposed in this preclinical application take a multidisciplinary genetic, pharmacological, and molecular approach to elucidate the role of TARP γ-8, a novel AMPAR auxiliary protein, in the regulation of dependence-escalated alcohol self-administration.

PI_NAMEs: HOFFMAN, JESSICA LEA (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Address;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol reinforcement;alcohol response;alcohol use disorder;Alcohols;AMPA Receptors;Amygdaloid structure;Automobile Driving;Behavior;Behavior assessment;Behavioral;behavioral plasticity;Binding;Brain;Brain region;brain reward regions;Calcium;Calcium Signaling;calmodulin-dependent protein kinase II;career;Chronic;Confocal Microscopy;craving;Data;Dependence;Development;drinking;Ethanol;excitatory neuron;experience;experimental study;Fiber;Gene Expression;Genetic;genetic regulatory protein;Glutamates;Hippocampus;Infusion procedures;inhibitor;innovation;insight;Integral Membrane Protein;interdisciplinary approach;Knowledge;Learning;Link;Maintenance;Measures;Medial;Mediating;Membrane;Memory;Methods;Modeling;Molecular;multidisciplinary;Mus;neural;neuromechanism;novel;Nucleus Accumbens;Pathologic;Pathology;Pathway interactions;Permeability;pharmacologic;Pharmacology;Phase;Phosphorylation;Photometry;pre-clinical;preclinical study;Prefrontal Cortex;Process;Property;Prosencephalon;Proteins;receptor expression;receptor function;Receptor Inhibition;Regulation;Resistance;Rewards;Role;Scientist;selective expression;Self Administration;Severities;Site;Synaptic plasticity;Synaptic Transmission;Techniques;Testing;trafficking;Training;transmission process;Up-Regulation;vapor;Withdrawal;Work

PROJECT_TITLE: Pathological AMPA receptor adaptations governing dependence-escalated alcohol self-administration

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Genetics

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: Narrative Protection of DNA against damages and errors are integral to maintaining genomic stability. Defects in DNA metabolic processes that replicate and repair the genome lead to genetic instability and chromosomal rearrangements causing cancers, aging, and inherited disorders. Replication Protein A is central to coordinating almost all DNA replication and repair processes in the cell and our work focuses on deciphering the underlying molecular mechanisms which can be exploited to develop novel chemotherapeutics.

PI_NAMEs: ANTONY, EDWIN  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Adopted;Affinity;Aging;Amino Acids;Architecture;Binding;Biochemical;Biophysics;Cancer Etiology;Cells;Chromosomal Rearrangement;Complex;Defect;dexterity;Dissociation;DNA;DNA Binding;DNA Binding Domain;DNA biosynthesis;DNA damage checkpoint;DNA Maintenance;DNA metabolism;DNA Repair;DNA Repair Pathway;ds-DNA;Enzymes;flexibility;Fluorescence;Gatekeeping;Genetic;Genetic Recombination;Genome;genome integrity;Genome Stability;Goals;Hereditary Disease;Individual;Investigation;Kinetics;Knowledge;Label;Lead;Length;Metabolic;Metabolism;Modeling;Molecular;novel;Nucleosomes;Pathway interactions;Phosphorylation;Positioning Attribute;Post-Translational Protein Processing;Process;Property;protein function;Proteins;recruit;repaired;replication factor A;Replication-Associated Process;Role;Single-Stranded DNA;Site;Specificity;telomere;Telomere Maintenance;Therapeutic;Thermodynamics;tool;Work

PROJECT_TITLE: Coordination of DNA Metabolism by Replication Protein A

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Pediatric

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This renewal application is aimed at continuing to prepare physicians for independent careers in the investigation and treatment of childhood psychiatric disorders. Such training and education programs are urgently needed. This need is based on the large number of children affected, the considerable costs to society associated with their care, the limited effectiveness of available treatment and prevention programs, the small number of physician-scientists active in the field, and the potential for significant scientific advances in the foreseeable future.

PI_NAMEs: MARTIN, ANDRES S (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: academic review;Academy;Accreditation;Achievement;Address;Adolescent;adolescent mental health;Adolescent Psychiatry;Adult;Affect;American;Applications Grants;Appointment;Award;base;Behavioral Research;Biomedical Research;Cancer Education Grant Program;career;Caring;Child;Child Mental Health;Child Psychiatry;Childhood;Clinical;Clinical Sciences;cohort;Collaborations;Colorado;cost;Country;Creativeness;Dedications;design;Deterioration;Development;disability;education research;Educational Grants;Effectiveness;Eligibility Determination;Enrollment;Ethnic Origin;experience;Exposure to;Faculty;Family;Fostering;Foundations;Funding;Future;Goals;graduate medical education;graduate school;Grant;hands on research;Home;indexing;Individual;innovation;Institution;Interdisciplinary Study;International;Investigation;Journals;K-Series Research Career Programs;Leadership;Measures;medical schools;member;Mental disorders;Mental Health;Mentors;Mentorship;Modeling;Morbidity - disease rate;mortality;Names;Neurology;next generation;Participant;participant enrollment;Pathway interactions;Peer Review;Physicians;Positioning Attribute;Post Graduate Year;Postdoctoral Fellow;Prevention program;Privatization;Productivity;Professional Organizations;programs;Psychiatrist;Psychiatry;Publications;Race;recruit;Research;Research Personnel;Research Training;Risk;Role;Scholarship;Scientific Advances and Accomplishments;Scientist;Series;severe mental illness;Site;skills;Societies;Structure;success;Training;Training and Education;treatment program;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Vermont;Woman;Work

PROJECT_TITLE: Research Education for Future Physician-Scientists in Child Psychiatry


NIH_SPENDING_CATS: Cancer;Skin Cancer

ORG_CITY: NEW YORK

ORG_DEPT: DERMATOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Metastasis is the main cause of cancer-related deaths however no effective therapies exist to specifically target metastatic disease. Here we use a clinically relevant patient-derived model of melanoma metastasis to examine the role of different isoforms of NAD+ kinase in oxidative stress resistance during metastatic colonization. Our study will establish the role and regulation of a specific NAD+ kinase isoform in metastasizing melanoma cells and determine the role of subcellular oxidative stress in limiting metastatic spread.

PI_NAMEs: PISKOUNOVA, ELENA  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Adopted;Affinity Chromatography;Anoikis;Antioxidants;Automobile Driving;Binding;cancer cell;Cancer cell line;Cancer Etiology;Cancer Patient;cancer survival;Carbon;Cell Line;cell regeneration;cell type;Cells;Cessation of life;ChIP-seq;Circulation;clinical predictors;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Cytoplasm;Data;Dependence;Disease;Disease Outcome;effective therapy;Environment;Enzymes;Event;experience;Frequencies;Genetic;Homeostasis;Human;Immunocompromised Host;In Situ;in vitro Model;in vivo;Invaded;Malignant neoplasm of pancreas;Malignant Neoplasms;Melanoma;Melanoma Cell;Metabolic;Metabolic Pathway;metabolic profile;Metastatic Melanoma;migration;Mitochondria;Modeling;Molecular;mortality;mouse model;Mus;Mutation;NAD+ kinase;NADP;Nature;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Nodule;Normal Cell;Normal tissue morphology;novel;novel therapeutics;Organ;Organelles;overexpression;Oxidation-Reduction;Oxidative Stress;Pathway interactions;patient derived xenograft model;Patients;Physiological;Primary Neoplasm;Production;Proliferating;promoter;Protein Isoforms;Protein Sequence Analysis;Reactive Oxygen Species;Reduced Glutathione;Regulation;Regulatory Element;Reporter;Resistance;response;Role;sensor;Signal Transduction;Stress;subcutaneous;targeted treatment;Testing;Therapeutic Intervention;Therapeutically Targetable;transcription factor;Transcription Initiation Site;Transcriptional Regulation;tumor;tumor progression;Up-Regulation;Visceral;Work

PROJECT_TITLE: Differential role of different NAD+ kinase Isoforms in melanoma metastasis

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE: A wealth of information has been accumulated about individual biological machineries that read our genetic information, and a number of critical regulatory steps within this multi-step process have already been identified. Nonetheless, an understanding at the molecular and mechanistic level of the true composition of these large biological machineries and how their interactions are precisely controlled is far from complete. Using a multi- pronged approach, we propose to investigate these machineries in their native state to elucidate their regulation and interactions, and thereby, identify key therapeutic targets and generate reagents that may serve as drugs or as leads for drug discovery.

PI_NAMEs: APOSTOLOU, EFFIE ;JOSEFOWICZ, STEVEN ZVI;LIS, JOHN T (contact);YU, HAIYUAN

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Advisory Committees;Affect;Affinity;Affinity Chromatography;aptamer;Architecture;ATAC-seq;Automobile Driving;Base Pairing;Binding;Biological;biological adaptation to stress;Biological Assay;Biotinylation;Cell Separation;Cells;Chemicals;ChIP-seq;Chromatin;Complex;conflict resolution;Consensus;crosslink;Crosslinker;Cryoelectron Microscopy;Detection;Developmental Gene;Dimensions;Disease;drug discovery;Ensure;Epigenetic Process;Funding;Gene Expression Regulation;gene induction;Genes;genetic information;Genetic Transcription;Genome;genome-wide;Goals;Health;Heterogeneity;Human;improved;Individual;Inflammatory;inhibitor;insight;Knowledge;Lead;Learning;Location;Macromolecular Complexes;Mass Spectrum Analysis;Measures;meetings;member;Membrane Proteins;Messenger RNA;Methods;Mitosis;Modeling;Molecular;molecular mechanics;molecular modeling;Monitor;novel;novel therapeutics;Pharmaceutical Preparations;Phosphorylation;Physiological;Polymerase;Positioning Attribute;Precision Run-On Sequencing;Process;promoter;Proteins;Protocols documentation;Publications;Reagent;recruit;Regulation;Research;Research Personnel;Resolution;RNA;RNA Polymerase II;Role;Specificity;Streptavidin;Structure;Surface;Technology;Testing;therapeutic development;Therapeutic Intervention;therapeutic target;transcription factor;Transcriptional Regulation

PROJECT_TITLE: Structure, Function, and Dynamics of Macro-molecular Complexes that Execute and Regulate Genome Function


PHR: Project Narrative G protein-coupled receptors (GPCRs) are the target of more than a third of drugs current prescribed in the clinic, and new GPCR targeting therapeutics hold the potential to significantly improve human health. Recent breakthroughs have identified a population of GPCRs which signal from endosomes as a new therapeutic drug target. Toward this end, we seek to understand the fundamental mechanisms of GPCR sorting and signaling at endosomes. By understanding how these processes operate, our studies aim to guide future drug development targeting endosomal GPCR signaling.

PI_NAMEs: LOBINGIER, BRADEN  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Address;Adrenergic Receptor;Area;Automobile Driving;beta-2 Adrenergic Receptors;Binding;Biological;Biology;Cell surface;Cells;Chemicals;Clinic;Consensus;drug development;Drug Targeting;Endosomes;Event;Family;Future;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic Engineering;Genomics;Goals;GTP-Binding Proteins;Health;Human;improved;Kinetics;Knowledge;Mediating;Membrane;Modeling;Molecular;novel therapeutics;Pathway interactions;Pharmaceutical Preparations;Population;Process;Proteins;Proteomics;receptor;receptor function;response;Signal Transduction;Signaling Molecule;Signaling Protein;Sorting;targeted treatment;Testing;trafficking;Work

PROJECT_TITLE: Endosomes as a multifunctional hub to control GPCR function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: ATLANTA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: It is highly significant to develop new influenza vaccines improving cross protective efficacy in young naïve and aged populations under naïve and pre-existing immune conditions. The outcomes in this project will be translational and relevant to improve the cross protective efficacy of influenza vaccination and will have significant impact in the influenza vaccination program and public health.

PI_NAMEs: KANG, SANG-MOO  (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: Adjuvant;Adult;Affinity;Age;aged;Aging;aging population;aging related;Animal Model;Animals;Antibodies;Antibody Affinity;Antigen Targeting;Avian Influenza;B-Lymphocytes;Cells;Cessation of life;Chemicals;Chickens;Collaborations;Complex;Consensus;cross immunity;Crosslinker;Data;design;Development;efficacy evaluation;efficacy testing;Elderly;Epitopes;Exposure to;Extracellular Domain;Ferrets;flu;Generations;Hemagglutinin;Human;human old age (65+);Immune;Immune Sera;Immunity;Immunization Programs;immunogenic;immunogenicity;Immunoglobulin G;immunosenescence;improved;Individual;Influenza;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;Influenza A Virus, H5N1 Subtype;Influenza A Virus, H7N9 Subtype;Influenza A Virus, H9N2 Subtype;influenza infection;Influenza vaccination;influenza virus vaccine;Knockout Mice;Length;Link;manufacture;mouse model;Mus;Mutate;nanoparticle;Neuraminidase;novel;old mice;Outcome;particle;Phylogenetic Analysis;Preparation;protective efficacy;Proteins;Public Health;Recombinants;Reporting;response;Role;seasonal influenza;Seasons;Structure of germinal center of lymph node;Surface;T-Lymphocyte;Tandem Repeat Sequences;Testing;translation to humans;Translational Research;universal influenza vaccine;universal vaccine;Vaccination;vaccination strategy;vaccine candidate;vaccine immunogenicity;vaccine strategy;vaccine-induced immunity;Vaccines;Virus;Virus Diseases;Virus-like particle;young adult

PROJECT_TITLE: Seasonal and universal Vaccination in aged populations with pre-existing immunity


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Data Science;Rheumatoid Arthritis

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Tissue inflammation is central to a wide range of human diseases, including immune-mediated and autoimmune diseases such as Psoriatic Spectrum Disease, Rheumatoid Arthritis, Sjogren’s Syndrome, and Systemic Lupus Erythematosus. The key cell-states driving tissue inflammation are now being discovered. Here we propose a Systems Biology Core to enable the AMP AIM network to define these key cell states, their spatial localization, and their interactions with each other.

PI_NAMEs: RAYCHAUDHURI, SOUMYA  (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Acceleration;algorithm development;Algorithms;analytical method;Autoimmune;Autoimmune Diseases;Automobile Driving;B-Lymphocytes;bioinformatics tool;biological systems;Blood specimen;CD8-Positive T-Lymphocytes;Cells;Cellular Assay;Clinical;Clinical Data;Collaborations;Communities;Complex;complex data;Computational Biology;computerized tools;Computing Methodologies;Consultations;Cues;Data;Data Analyses;data integration;data modalities;data resource;Data Set;Development;Disease;Education;Ensure;Epigenetic Process;experience;Fibroblasts;Genetic;Genomics;Goals;Helper-Inducer T-Lymphocyte;high dimensionality;Histologic;HLA-DR Antigens;Hospitals;human disease;Immune;Individual;Inflammation;Inflammatory;innovation;International;investigator training;Leadership;Mediating;Medicine;Methods;Modality;Molecular;multidimensional data;multimodal data;multimodality;Nephritis;novel;novel strategies;Outcome;Pathway interactions;Patients;Peripheral;Phenotype;Positioning Attribute;Process;programs;Proteins;Proteomics;Psoriasis;Quality Control;Reproducibility;Research;Rheumatism;Rheumatoid Arthritis;Rheumatology;Sampling;single cell genomics;Sjogren's Syndrome;skills;Statistical Methods;success;System;Systemic Lupus Erythematosus;Systems Biology;Technology;text searching;Tissue Model;Tissue Sample;Tissues;tool;Training;Transcript;transcriptomics;Validation;Woman

PROJECT_TITLE: Integrative analysis of high dimensional tissue molecular data to define key biological systems in autoimmune diseases (SBC)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

PHR: The  burden  of  frontotemporal  dementia,  amyotrophic  lateral  sclerosis,  and  other  TDP- 43- related  proteinopathies  including  Alzheimer’s  disease  is  large,  yet  no  effective  therapeutics  exist  to  effectively  slow  disease  onset  or  progression.  The  studies  outlined  in  this  proposal  will  allow  us  to  determine  the  molecular  mechanisms  underlying  the  regulation  of  lysosomal  gene  expression  in  neurons,  and  to  rigorously  test  the  therapeutic  potential  of  a  novel  approach  to  increase  lysosome  biogenesis  in  animal  models  of  TDP- 43  proteinopathy,  which  may  eventually  lead  to  the  development  of  improved  treatments  for  a  range  of  neurodegenerative diseases in the future.

PI_NAMEs: LIM, JANGHOO  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Adult;Affect;ALS patients;Alzheimer's Disease;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Animal Model;Antisense Oligonucleotides;Autophagocytosis;Behavioral;Behavioral Assay;Biochemical;Biogenesis;Bioinformatics;cell type;Cortical Cord;Cytoplasm;Cytoplasmic Inclusion;Data;Development;Disease;Disease Progression;DNA-Binding Proteins;Effectiveness;Etiology;Evaluation;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Future;Gene Expression;Genetic;Genetic Transcription;Goals;improved;in utero;in vivo;in vivo Model;insight;Lysosomes;Mediating;Molecular;Motor;motor deficit;Motor Neurons;mouse model;Mus;nemo-like kinase;Nervous System;Neurodegenerative Disorders;Neuroglia;Neurons;neuropathology;novel;novel strategies;Nuclear;Onset of illness;Organelles;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Phenotype;phosphoproteomics;Phosphorylation;Play;postnatal;Pre-Clinical Model;prevent;protein aggregation;protein TDP-43;Protein-Serine-Threonine Kinases;Proteins;Quality Control;Regulation;Research;response;Role;Serine;Spinal Cord;TDP-43 aggregation;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutically effective;transcription factor;transcriptomics

PROJECT_TITLE: Evaluation of a novel NLK function in lysosome biogenesis and neurodegenerative diseases

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD-M]


ORG_STATE: NY

PHR: As a result of their numerous and varied biological roles, RNA and DNA are drug targets and therapeutic agents. This project applies state-of-the-art measurement and modeling techniques to watch these molecules as they interact with cellular partners. The critical insight gained will expand understanding of how genes are regulated, an important consideration in treating diseases like cancer.

PI_NAMEs: POLLACK, LOIS  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Biological;Biology;computerized tools;Coupled;Disease;DNA;Drug Targeting;Elements;flexibility;Gene Expression;Genes;insight;Ions;Ligands;Malignant Neoplasms;Measurement;Modeling;Molecular Conformation;molecular scale;Motivation;mRNA Translation;new therapeutic target;nucleic acid structure;Nucleic Acids;Pharmaceutical Preparations;programs;protein complex;Proteins;Resolution;RNA;Role;Signal Transduction;Structure;targeted agent;Techniques;Therapeutic Agents;Therapeutic Intervention;Vaccines;Variant

PROJECT_TITLE: Exploring the Dynamic Structures of Nucleic Acids

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative There is a major national shortage of qualified clinicians trained to conduct rigorous research in clinical pharmacoepidemiology, and in particular research focusing on drug safety and comparative effectiveness research/patient-centered outcomes research. This training program helps to address this shortage by providing clinicians with rigorous didactic training and the opportunity to conduct mentored research mentored by outstanding program faculty.

PI_NAMEs: HENNESSY, SEAN  (contact);LO RE, VINCENT

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TITLE: Clinical Pharmacoepidemiology Training Grant


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Suicide;Suicide Prevention

ORG_NAME: COLUMBIA UNIVERSITY TEACHERS COLLEGE

PHR: PROJECT NARRATIVE Suicide is the second leading cause of death in adolescents and young adults, and identifying high-risk young people remains an immense challenge. The proposed research will employ machine learning-based approaches to test whether non-verbal behaviors (i.e., paralinguistic characteristics, spontaneous facial action, and head motion) exhibited during suicide assessments can be used to identify adolescents and young adults with recent suicidal ideation. This project may inform the development of an objective method of detecting suicide risk at scale.

PI_NAMEs: GRATCH, ILANA  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Adolescent and Young Adult;Area;Behavior;Behavioral;Behavioral Model;Cause of Death;Characteristics;Clinical;Code;Computational Science;Computing Methodologies;Contracts;Data;Detection;detection method;Development;Disease;Exhibits;experience;Face;Feeling;Feeling suicidal;Goals;Head;Head Movements;Health Personnel;Health Professional;high risk;Human;indexing;inferential statistics;Interview;Interviewer;Lateral;Machine Learning;Manuals;Mental Health;Motion;Movement;Muscle;Nature;non-verbal;Participant;Patients;Persons;Process;prospective;Radial;Reaction Time;Recording of previous events;Reporting;Research;Research Personnel;response;Risk;Self Administration;Severities;Smiling;Speech;suicidal;suicidal adolescent;suicidal behavior;suicidal individual;suicidal risk;Suicide;Suicide prevention;support vector machine;Surface;Task Performances;Testing;Thinking;Training;United States;Validation;Video Recording;Work;young adult;Youth

PROJECT_TITLE: Detecting suicide risk in adolescents and young adults: A machine learning-based analysis of nonverbal behaviors exhibited during suicide assessments


ORG_CITY: CHICAGO

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Narrative Cytokine signaling is essential to immune function and is an area with great clinical therapeutic potential. Dozens of cytokine families have different roles in the immune system which all signal through their specific combinations Janus kinases (Jaks) and STAT proteins. We propose using biochemistry, biophysics, and protein engineering to understand how the different cytokine receptor families interact with the Jaks and STATs which will identify new targets for tuning cytokine signaling.

PI_NAMEs: MENDOZA, JUAN LUIS (contact)

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;Apoptosis;Area;Binding;Biochemistry;Biophysics;Cell Nucleus;Clinical;cytokine;Cytokine Receptors;Cytokine Signaling;Defense Mechanisms;Dimerization;Disease;Engineering;Family;Genes;Health;Hematopoiesis;Human;immune function;Immune response;Immune system;Infection;Inflammation;Innate Immune System;Interferon Type II;Interferons;Interleukin-2;Janus kinase;Knowledge;Malignant Neoplasms;microbial;Molecular;novel therapeutic intervention;Phosphorylation;Play;Protein Engineering;protein protein interaction;Proteins;receptor;response;Role;Shapes;Signal Transduction;STAT protein;System;T cell response;Technology;Therapeutic;Therapeutic Intervention;Time;tool development

PROJECT_TITLE: Shedding new light on cytokine signaling through molecular engineering

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


PHR: PROJECT NARRATIVE Eccrine sweat glands are a type of ectodermal appendage and are essential for human thermoregulation. This proposal builds on our previous work implicating the transcription factor Engrailed-1 as a major determinant of eccrine fate to interrogate the eccrine gland developmental program. The aims of this proposal are to define the transcription factors that regulate Engrailed-1 expression during eccrine gland placode specification and to determine the downstream cellular and molecular targets of Engrailed-1 which execute the differentiation of eccrine sweat glands from these primordia.

PI_NAMEs: KAMBEROV, YANA G (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Adopted;Alleles;appendage;base;Biology;Cell Nucleus;Cells;cellular targeting;Cessation of life;ChIP-seq;Clinical;Collaborations;comparative;Data;Data Set;Development;Dissection;eccrine;Eccrine Glands;Ectoderm;Enhancers;evaporation;experimental study;FBXO32 gene;Future;Gene Expression;Gene Expression Profile;gene repression;Genes;Genetic;Genetic Transcription;Genomics;Gland;gland development;Goals;Hair;Hair follicle structure;Heat Exhaustion;Heat Losses;Human;Hyperthermia;In Vitro;in vivo;in vivo evaluation;Intervention;jun Oncogene;keratinocyte;knock-down;Knock-in Mouse;Knock-out;Knockout Mice;lentiviral-mediated;Limb structure;loss of function;Medial;Mediating;Modeling;Molecular;Molecular Target;mouse model;Mus;Mutagenesis;Natural regeneration;novel;Organ;Outcome;overexpression;Pathologic;Pathway interactions;Patients;Phenotype;Physiologic Thermoregulation;Positioning Attribute;programs;Regulation;repaired;Risk;Role;Signal Induction;single nucleus RNA-sequencing;Skin;SP1 gene;Specific qualifier value;System;Technology;Testing;transcription factor;Transcription Factor AP-1;Transcription Repressor;Transcriptional Activation;transcriptomics;Validation;Work;wound

PROJECT_TITLE: Genetic and Cellular Mechanisms of Engrailed-1 Regulation and Function in Eccrine Sweat Gland Development

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]