ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: We propose to advance a novel liquid biopsy, focused on urine, to monitor bladder cancer patients under immunotherapy treatment. We will specifically exploit urinary extracellular vesicles (uEVs) as a novel biomarker, and molecularly profile them using an enhanced nanoplasmonic-electrochemical platform. Our translational study will critically evaluate and establish this new EV assay for accurate and timelier bladder cancer cancer detection and treatment monitoring.

PI_NAMEs: CASTRO, CESAR M (contact);LEE, HAKHO

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Acceleration;Anatomy;Bioinformatics;Biological Assay;Biological Markers;Biological Specimen Banks;Biology;biomarker identification;biomarker panel;Biomedical Engineering;Bladder;Bladder Urothelium;Cancer cell line;Cancer Detection;Cancer Patient;cancer therapy;cell bank;Cells;Charge;Clinical;clinical imaging;clinical investigation;Clinical Oncology;Clinical Trials;Collection;commercialization;Consensus;Correlative Study;Coupled;Coupling;Decision Making;Detection;Devices;Diagnostic;effective therapy;exosome;expectation;experience;extracellular vesicles;Generations;Genitourinary system;Glean;Graft Rejection;Guidelines;Human;Image;Image Analysis;imaging modality;Immune checkpoint inhibitor;Immunotherapy;improved;innovation;insight;instrumentation;Investigation;Kidney;Kidney Transplantation;Laboratories;Light;liquid biopsy;Location;Magnetism;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;Membrane;Messenger RNA;Molecular;Molecular Profiling;Monitor;multidisciplinary;nanoGold;nanometer;nanoplasmonic;Nanotechnology;Neoplasm Metastasis;novel;novel marker;Nucleic Acids;Oncologist;Patients;Performance;peripheral blood;personalized immunotherapy;Pharmacodynamics;Physics;plasmonics;pre-clinical;pressure;prospective;Prostate;Proteins;Protocols documentation;Reaction;Regimen;Regression Analysis;repository;Research Personnel;response;Sampling;sensor;Signal Transduction;Source;Surface;System;Systems Biology;Testing;Time;tool;Traction;translational study;treatment strategy;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;urinary;Urine;Urogenital Cancer;X-Ray Computed Tomography

PROJECT_TITLE: High throughput nanoplasmonic exosome testing (NEXT) of immunotherapies in bladder cancer


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative  Chronic pain is a serious health concern effecting millions of American annually. In this application we are proposing to use innovative physiological, pharmacological and calcium imaging approaches, together with a novel somatosensory preparation to characterize the spinal circuitry involved in processing both nociceptive and non-nociceptive information. These studies will provide new knowledge about how specific populations of spinal neurons interact to form networks that process peripheral sensory information under normal conditions and following neuropathic injury.

PI_NAMEs: KOERBER, H RICHARD (contact);ROSS, SARAH ELIZABETH

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Acute;Address;Agonist;allodynia;American;Brain;Calcium;calcium indicator;Capsaicin;Catalogs;cell type;Cells;cellular imaging;central sensitization;Chemicals;Chronic;chronic pain;Code;Coupled;Cutaneous;Data;dorsal horn;effective therapy;excitatory neuron;experience;G-Protein-Coupled Receptors;Goals;Hand;Health;heat stimulus;Hyperalgesia;Image;imaging approach;imaging study;Individual;injured;Injury;innovation;insight;Knowledge;Label;Measures;mechanical stimulus;Mechanics;Modeling;Mus;Nerve;nerve injury;neural;neural circuit;Neurons;Neuropathy;new therapeutic target;Nociception;novel;novel strategies;Optics;Output;Pain;pain chronification;Pain management;pain sensation;Patients;Peripheral;Persistent pain;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Population;Preparation;Process;programs;Property;Quality of life;receptor;recruit;Research;response;Sensory;sensory input;sensory integration;sensory stimulus;Series;Skin;somatosensory;spared nerve;Spinal;Spinal Cord;Stimulus;Testing;Tetrodotoxin;Thermal Hyperalgesias;tool;Transgenic Mice;two-photon;Visualization

PROJECT_TITLE: Comprehensive Phenotyping of Specific Populations of Spinal Neurons Processing Cutaneous Information Before and After Injury

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: DETROIT

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Cancer is the 2nd major cause of human mortality. Consequently, PhDs and MD/PhDs specifically trained in the discipline of Cancer Biology and professionally involved in cancer research, education, policy and clinical care are a critical national health need. This training grant currently in its 35th year is a cornerstone of a unique interdisciplinary graduate program designed to train the next generation of cancer biologists to meet this urgent national need.

PI_NAMEs: MATHERLY, LARRY H (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Cancer Biology;Training Programs

PROJECT_TITLE: Training Program in the Biology of Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE (RELEVANCE)  The impact of gene loss on complex phenotypes is strongly influenced by the cellular context and the genetic background. Working with consortium partners, we will prioritize the target genes for Phase 1 of the MorPhiC project, develop standards for data and resource sharing, and optimize methods for joint analyses. Our Production Center is expected to deliver a rich resource of knockout human pluripotent stem cell lines from diverse genetic backgrounds, extensive knockout phenotyping datasets in multicellular contexts that are informative of diverse human biology, robust and scalable knockout and phenotyping pipelines along with associated transferable methods and establish strong use cases for the MorPhiC catalog.

PI_NAMEs: HUANGFU, DANWEI  (contact);STUDER, LORENZ P.

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: 3-Dimensional;Address;Affect;Astrocytes;autism spectrum disorder;Biological Assay;Catalogs;Cell Line;Cell Physiology;cell repository;Collection;Communities;Complex;CRISPR/Cas technology;Data;Data Set;data sharing;data standards;Diabetes Mellitus;Disease;disease phenotype;Embryo;endodermal progenitor;Engineering;ES Cell Line;ethnic minority population;experience;Experimental Designs;Feedback;Female;Foundations;Future;Genes;Genetic;Genetic study;Genetic Variation;genome-wide;Germ Layers;Goals;Human;Human Biology;human disease;Human Genetics;Human Genome;human pluripotent stem cell;induced pluripotent stem cell;information gathering;Investigation;Investments;islet;Islets of Langerhans;Joints;Knock-out;knockout gene;Knockout Mice;large scale production;Link;male;member;Metabolic;Metabolic Diseases;Methods;Microglia;Mission;Modeling;multimodality;Mutagenesis;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;Non-Insulin-Dependent Diabetes Mellitus;Organoids;Pattern;Penetrance;Phase;Phenotype;phenotypic data;pluripotent stem cell differentiation;Population;Production;programs;Publications;Quality Control;racial minority population;Research;Research Personnel;Resource Sharing;Resources;screening;single-cell RNA sequencing;Societies;Specific qualifier value;System;Testing;Time;Underrepresented Populations;Work

PROJECT_TITLE: Center for scalable knockout and multimodal phenotyping in genetically diverse human genomes


ADMINISTERING_IC: EY

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: FORT WORTH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

ORG_STATE: TX

PHR: Narrative The broad use of anti-inflammatory steroids in millions of patients can cause elevated pressure inside eyes leading to glaucomatous loss of vision in susceptible individuals, which is a clinically significant problem. This steroid response is found in most glaucoma patients and is an important risk factor in the development of glaucoma. We have discovered a likely mechanism and are identifying genes responsible for this steroid responsiveness, which may play a major role in the development of glaucoma.

PI_NAMEs: CLARK, ABBOT FREDERICK (contact);GEISERT, ELDON E

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Alternative Splicing;Anterior;Anti-Inflammatory Agents;Antiinflammatory Effect;aqueous;Aqueous Humor;Biochemical;Bioinformatics;Biological;Biological Markers;Blindness;Cell Separation;Cells;Chromosome Mapping;Chronic;Clinical;clinically relevant;clinically significant;Cornea;Data;Development;differential expression;Disease;Disease Resistance;Disparate;Dominant-Negative Mutation;ex vivo perfusion;Eye;gene therapy;Generations;Genes;Glaucoma;Glucocorticoid Receptor;Glucocorticoids;Human;Iatrogenesis;Immunosuppressive Agents;in vivo;Inbred Mouse;Individual;Inherited;innovation;knock-down;Link;man;Maps;Mediating;Mediator;Molecular;molecular phenotype;mouse model;Mouse Strains;Mus;Ocular Hypertension;Open-Angle Glaucoma;Pathway interactions;Patients;Perfusion;pharmacologic;Phenotype;Physiologic Intraocular Pressure;Play;Population;Predisposition;pressure;Primary Open Angle Glaucoma;Protein Isoforms;Quantitative Trait Loci;receptor expression;Receptor Inhibition;Recombinants;Reproducibility;Research;Resistance;Resistant Hypertension;responders and non-responders;response;Retinal Diseases;Risk Factors;RNA Interference;Role;side effect;Spliceosomes;Steroids;Testing;Therapeutic Agents;therapy development;Tissues;Trabecular meshwork structure;Transactivation;transcriptome;transcriptome sequencing;Work

PROJECT_TITLE: Glucocorticoids, ocular hypertension and glaucoma


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: IRVINE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PUBLIC HEALTH RELEVANCE Exposure to environmental agents can induce abnormal skeletal development posing lifelong implications for the patient’s health. This study is significant because it will reveal a novel mechanism whereby environmental toxicants influence osteoblast differentiation through alterations in microRNA expression. Through this, this proposal is relevant to the mission of NIH to increase understanding of how the environment affects biological processes to advance disease diagnosis, treatment, prevention, and ultimately support healthier lives.

PI_NAMEs: SPARKS, NICOLE RENEE (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Accounting;advanced disease;Adverse effects;adverse outcome;Affect;ATAC-seq;Bioinformatics;Biological;Biological Process;biomarker identification;bone;Bone Development;career development;Cells;Chemical Exposure;Chemicals;Chromatin;Communication;Complex;Congenital Abnormality;Cytogenetic Analysis;Data;Defect;Development;Development Plans;Disease;disease diagnosis;DNA;DNA Methylation;DNA methyltransferase inhibition;early embryonic stage;Electroporation;Environment;environmental agent;environmental chemical exposure;Epigenetic Process;epigenetic regulation;Etiology;experimental study;Exposure to;Failure;Frequencies;Gene Expression;Generations;Genes;Genetic;Genetic Transcription;Genome engineering;Genomics;Global Change;Goals;Health;human embryonic stem cell;Hypermethylation;in utero;In Vitro;in vivo;independency;Infant Mortality;interest;Investigation;knock-down;Knock-out;Knockout Mice;Knowledge;malformation;Mediating;Mentors;Messenger RNA;Methylation;MicroRNAs;miRNA expression profiling;Mission;Modification;Molecular;mRNA Expression;Mus;next generation sequencing;non-genetic;novel;Ontology;Operative Surgical Procedures;osteoblast differentiation;Osteoblasts;Osteogenesis;osteogenic;Outcome;overexpression;Pathway interactions;Patients;Physiologic calcification;Play;pregnant;prenatal exposure;Prevention;Principal Investigator;Process;promoter;Proteins;Public Health;public health relevance;Regulation;Repression;Research;Risk;Role;Science;Signal Pathway;skeletal;skeletal abnormality;Skeletal Development;skeletal disorder;Skeletal system;Skeleton;skills;stem;success;System;Systems Development;Testing;Therapeutic;Tissue-Specific Gene Expression;Toxic effect;Toxic Environmental Substances;toxicant;Toxicant exposure;Toxicology;Training;transcriptome sequencing;United States;United States National Institutes of Health;Untranslated RNA;Validation;Writing

PROJECT_TITLE: Analysis of environmentally-sensitive epigenetic machinery during osteogenic differentiation


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: INDIANAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Lysine methylation is a widespread posttranslational modification, and the enzymes responsible for adding and removing lysine methylation are dysregulated in many human diseases. While we understand much about lysine methylation on histone proteins, thousands of non-histone proteins are also methylated. Our research aims to determine how non-histone lysine methylation regulates protein function and ultimately impacts cellular processes.

PI_NAMEs: CORNETT, EVAN MITCHELL (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Biochemistry;Biological Process;Cell Physiology;Cells;Chromatin;circadian;circadian pacemaker;developmental disease;Enzymes;Genomics;Goals;Histones;Human;human disease;Lysine;Maps;Mass Spectrum Analysis;Methods;Methylation;methylome;Methyltransferase;Neuronal Differentiation;non-histone protein;Physiological;Post-Translational Protein Processing;Process;protein function;Proteins;Proteome;Proteomics;Regulation;Research;Resolution;Signal Transduction;Substrate Specificity

PROJECT_TITLE: Regulation of non-histone protein function by lysine methylation

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: BIRMINGHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE (OVERALL) Every undiagnosed disease program faces a huge problem of having identified significant numbers of genomic variants with insufficient functional evidence for clinical reporting and thus lacking clinical actionability. The UAB Center for Precision Animal Modeling (C-PAM) will develop a strategy and pipeline for efficient modeling and analysis of genomic variants of uncertain significance that are associated with a disease to determine if the variant is causal of the disease, to evaluate the significance on gene function and disease pathophysiology, and to support identification and evaluation of therapeutic targets. C-PAM will accomplish this by analyzing variants using a series of rigorous clinical and innovative bioinformatic tools and through the generation and distribution of clinically and molecular informative animal models to the research community.

PI_NAMEs: MIGHT, MATTHEW BRENDON;YODER, BRADLEY K. (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Address;Animal Disease Models;Animal Model;animal resource;Animals;Basic Science;Bioinformatics;bioinformatics infrastructure;bioinformatics pipeline;bioinformatics tool;Biological;causal variant;Characteristics;Classification;Clinical;Clinical assessments;clinical center;Clinical Data;clinical diagnosis;Clinical Distribution;clinical phenotype;Clinical Sciences;clinically actionable;Collaborations;Collection;Communities;Complex;Computational Science;cost;Cost Effectiveness Analysis;Data Science;Data Set;Decision Making;Diagnosis;diagnostic tool;Disease;disease model;Drug Targeting;Etiology;expectation;Face;Family;Functional disorder;Future;gene function;Generations;Genes;Genetic Polymorphism;genetic variant;Genome;genome sequencing;genomic data;Genomic medicine;Goals;Health;Human;human disease;Human Genetics;improved;Individual;Informatics;Inheritance Patterns;innovation;Institute of Medicine (U.S.);Institution;inter-institutional;interdisciplinary approach;interest;Knowledge;Laboratories;Maps;Methodology;Mission;Modeling;Molecular;novel;novel therapeutic intervention;outreach program;Pathogenesis;Pathogenicity;Pathway interactions;patient advocacy group;Patient Care;Patients;Phenotype;phenotypic data;precision medicine;prevent;programs;protein function;Quality of life;Rare Diseases;Recording of previous events;recruit;Reporting;Research;Research Personnel;Resources;Scientist;Sequence Analysis;Series;Services;targeted treatment;Technology;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Translational Research;United States National Institutes of Health;Variant;variant of unknown significance;virulence gene;Vision;whole genome

PROJECT_TITLE: UAB Pilot Center for Precision Animal Modeling (C-PAM)


PI_NAMEs: YODER, BRADLEY K. (contact)

PROJECT_TERMS: Accounting;Address;Affect;Animal Disease Models;Animal Model;animal model selection;animal resource;Animals;Area;authority;Basic Science;Benchmarking;Bioethics Consultants;Bioinformatics;Biological;Biological Models;Caenorhabditis elegans;Clinical;clinical center;clinical diagnosis;Clinical Informatics;Clinical Sciences;Collaborations;Communication;Communities;Complex;Computational Science;cost;Data Science;Development;diagnostic value;Disease;disease model;disease phenotype;Disease Progression;disease-causing mutation;Eligibility Determination;Engineering;Ensure;Etiology;Evaluation;experience;Fee-for-Service Plans;Future;Generations;Genes;genetic variant;genome sequencing;Goals;Grant;Health;Human;human disease;Human Engineering;Human Genetics;Human Resources;IACUC;improved;indexing;Individual;Informatics;innovation;insight;Institutional Review Boards;interdisciplinary approach;interest;Leadership;Legal;Maps;Measures;Medical Genetics;Medicine;meetings;member;Mission;Modeling;multidisciplinary;Mus;novel;Occupations;operation;Organizational Models;organizational structure;outreach;Pathogenesis;Pathogenicity;patient advocacy group;Patient Care;Patients;Performance;Phase;Phenotype;phenotypic data;Procedures;programs;Quality Control;Rare Diseases;Rattus;recruit;Reporting;Reproducibility;Research;Research Personnel;Resource Sharing;Resources;Running;Scientist;Services;social media;Strategic Planning;System;targeted treatment;Technology;Testing;Therapeutic;Translational Research;United States National Institutes of Health;Variant;virulence gene;Vision;voucher;web page;whole genome;Work;Zebrafish

PROJECT_TITLE: UAB Pilot Center for Precision Animal Modeling (C-PAM) - Coordination Section

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-U]


PI_NAMEs: MIGHT, MATTHEW BRENDON (contact)

PROJECT_TERMS: Affect;Animal Model;Back;Bioinformatics;Biological;Biological Models;Blood;Cell Physiology;Classification;Clinic;Clinical;Clinical assessments;Clinical Data;clinical development;clinical phenotype;clinically relevant;Collection;Communication;Data;Development;Disease;disease model;drug discovery;Ensure;forgetting;gene therapy;Genes;Genetic Diseases;genetic variant;genomic data;Genomics;Genotype;Goals;Health Insurance Portability and Accountability Act;health record;Human;improved;Individual;Informed Consent;innovation;Intake;Internet;Knowledge;Learning;Light;Link;model development;Modeling;Online Systems;Ontology;Operative Surgical Procedures;Participant;Pathogenicity;Patient Care;Patients;Persons;Pharmaceutical Preparations;Phenotype;Physicians;pre-clinical;Pre-Clinical Model;Process;programs;Reporting;Research;Research Personnel;Research Subjects;Role;Saliva;Sampling;Scientist;Secure;Source;Specimen;Standardization;Study models;System;Therapeutic;Tissues;Update;Urine;Validation;Variant;variant of unknown significance;Work

PROJECT_TITLE: UAB Pilot Center for Precision Animal Modeling (C-PAM) - Preclinical/Co-Clinical Section


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE - MECHANOSURVEILLANCE IN BREAST CANCER METASTASIS Metastasis is the leading cause of breast cancer related deaths, but the majority of treatment options that target known abnormalities in cancer cells are not curative. In our effort to identify additional abnormalities in cancer cells for therapeutic targeting, we found that the immune system could sense and destroy cancer cells based on cancer cells’ altered biophysical stiffness. In this project, we aim to close the knowledge gap in our molecular understanding of this novel mode of immune surveillance, which we termed mechanosurveillance, in order to facilitate clinical progress in metastatic breast cancer treatment.

PI_NAMEs: ER, EKREM EMRAH  (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Actins;Activated Lymphocyte;Atomic Force Microscopy;Biochemical;Bioinformatics;biophysical properties;Biophysics;Blood Vessels;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;Breast Cancer Treatment;Calcium;Cancer Biology;cancer cell;Cancer Model;CD8B1 gene;cell transformation;Cells;Cessation of life;Chemicals;Clinical;Clinical Data;clinically relevant;Coculture Techniques;Complement Factor B;Confocal Microscopy;Coupled;Cytoplasmic Granules;Cytoskeleton;cytotoxic;Data;Data Analyses;Data Set;Diagnosis;Disease;Doxycycline;experimental study;factor A;Flow Cytometry;Future;Genes;Genetic;Genetic Epistasis;Genetic Transcription;Genomics;Goals;Histologic;Human;Image;Immune;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunocompetent;Immunocompromised Host;Immunologic Surveillance;immunological synapse formation;In Situ;In Vitro;in vivo;inducible gene expression;Infiltration;interdisciplinary approach;Invaded;junctophilin;Knowledge;Ligands;Lung;Lymphocyte;Lymphocyte Activation;Machine Learning;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;mechanical signal;mechanical stimulus;Mechanics;Mediator;Melanoma;Metastatic breast cancer;Metastatic Neoplasm to the Lung;Methods;Modeling;Molecular;Motility;mouse model;multiplexed imaging;Mus;mutant;myocardin;Natural Killer Cells;Neoplasm Metastasis;novel;novel therapeutics;Nuclear;Oncogenic;Organ;Organoids;overexpression;palliative;patient derived xenograft model;Patients;pharmacologic;Phosphorylation;Prevalence;prevent;Process;Prognosis;Proteins;Publishing;receptor;Regulation;Research Design;Sampling;Serum Response Factor;Structure;Surface;System;T-Cell Activation;T-Lymphocyte;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic target;Therapeutically Targetable;Tissue Sample;transcription factor;transcriptomics;treatment strategy;Woman;Work

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: WORTHEY, ELIZABETH A (contact)

PROJECT_TERMS: Accounting;animal data;Animal Model;Bioinformatics;Catalogs;Clinical;Code;Collaborations;Communities;Computer Analysis;computer framework;Computer software;computerized tools;Computing Methodologies;cost effective;Data;data access;Data Analytics;data modeling;data repository;Data Science;Data Set;data sharing;Data Sources;data warehouse;Decision Making;Deposition;design;Development;Diagnosis;Disease;drug candidate;drug repurposing;Drug Targeting;Ensure;Etiology;Evaluation;flexibility;Generations;Genes;Genetic;Genotype;Goals;Human;human model;Impact evaluation;Infrastructure;innovation;interest;Knowledge;Life Cycle Stages;Link;Machine Learning;Methodology;Methods;model organism;Modeling;Molecular;new therapeutic target;novel;Outcome;Output;Pathogenicity;Patients;Pharmaceutical Preparations;Phase;Phenotype;Physiological;pre-clinical;Process;programs;quality assurance;Quality Control;Rare Diseases;repository;Research;Research Personnel;Sampling;skills;software development;software infrastructure;Standardization;targeted treatment;Testing;Therapeutic;therapeutic candidate;therapeutic target;tool;transfer learning;Update;user-friendly;Variant;Visualization

PROJECT_TITLE: UAB Pilot Center for Precision Animal Modeling (C-PAM) - Bioinformatics Section


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Mental Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: Project Narrative The current lack of translatability with current pharmacologic strategies for traumatic brain injury (TBI) dictates that other therapeutic strategies be evaluated thereby increasing the probability of bench-to-bedside success. Neural stem cell therapies may be a feasible alternative to pharmacotherapies for improving function after TBI as they can exploit their inherent ability to migrate and stimulate endogenous repair mechanisms, and thus the proposed studies will use an established rat model of TBI to test LM-NSC008 cell migration, distribution, and therapeutic efficacy in both sexes. A rehabilitative approach is also included and consists of using environmental enrichment, a well validated preclinical model of neurorehabilitation combined with LM-NSC008 cells to accelerate clinical translation to patients with TBI.

PI_NAMEs: GUTOVA, MARGARITA ;KLINE, ANTHONY E. (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;Adult;Advocate;Affect;Affective;Allogenic;analytical method;Animals;Area;Attention;Behavior;Behavioral;behavioral outcome;bench to bedside;Biological Assay;Brain;Brain Injuries;brain tissue;Brain-Derived Neurotrophic Factor;Cell Lineage;cell motility;Cell Therapy;Cells;chemokine;Chronic;Clinic;Clinical;clinical translation;Clinical Trials;clinically relevant;Cognition;Cognitive;cognitive testing;Combined Modality Therapy;cytokine;Dendritic Cells;disability;Distal;Distant;DLG4 gene;DNA;Dose;Dyes;Educational workshop;efficacy evaluation;environmental enrichment for laboratory animals;Equilibrium;Evaluation;executive function;Exhibits;Expression Profiling;Female;FOXG1B gene;functional improvement;Gene Modified;glial activation;Glial Fibrillary Acidic Protein;Human;Immune;Immunohistochemistry;Impaired cognition;improved;Individual;Inflammation;Injury;Intranasal Administration;L-myc Gene;Learning;male;Mediating;Menstrual cycle;migration;Modeling;Morphology;Motor;nano-string;Natural regeneration;nerve stem cell;nestin protein;neural;neural network;neurobehavioral;neurological rehabilitation;neuron loss;Neurons;neurotrophic factor;neutrophil;Optics;Patients;pharmacologic;Pharmacotherapy;Phase;Pilot Projects;Pre-Clinical Model;preclinical study;Probability;Proteins;Protocols documentation;Rattus;Recommendation;Recovery;regeneration potential;Regenerative capacity;Rehabilitation therapy;repaired;Reporting;RNA;sex;Signal Transduction;Signaling Molecule;Site;stem cell therapy;success;Synapses;Synapsins;TBI Patients;TBI treatment;Techniques;Testing;Therapeutic;Time;Tissues;Translating;Translations;Trauma;Traumatic Brain Injury;Traumatic Brain Injury recovery;Treatment Efficacy;Tubulin;Tumorigenicity;United States National Institutes of Health;Visualization;Walking;water maze;white matter

PROJECT_TITLE: Neurobehavioral, cognitive, and mechanistic effects of intranasally administered neural stem cells and environmental enrichment after cortical impact injury in rats

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Heart Disease;Orphan Drug;Pediatric;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE  This project will study the effectiveness of performing "clinical trials in a dish" for an inherited arrythmia known as catecholaminergic polymorphic ventricular tachycadia. The study will advance our understanding of how iPSC-based, personalized tissue chip models can be used to predict individual patient responses and to plan and de-risk clinical trials.

PI_NAMEs: PARKER, KEVIN KIT;PU, WILLIAM TSWENCHING (contact)

PROGRAM_OFFICER_NAME: HARGROVE, PASSLEY R

PROJECT_TERMS: Accounting;Adrenergic beta-Antagonists;arm;Arrhythmia;Bioreactors;Boston;Calmodulin;Cardiac;cardiac implant;Cardiac Myocytes;Case Series;Catecholaminergic Polymorphic Ventricular Tachycardia;Cells;Cessation of life;Child;Clinical;clinical risk;Clinical Treatment;clinical trial in a dish;clinical trial on a chip;Clinical Trials;Clinical Trials Design;clinically relevant;Cryopreservation;Data;Defibrillators;Denervation;design;differentiation protocol;disease model;dominant genetic mutation;effective therapy;effectiveness study;efficacy evaluation;Emotional Stress;Event;Exercise;Exhibits;Flecainide;Future;Genes;Genetic;genome editing;Genotype;Goals;Human;improved;In Vitro;Individual;individual patient;individualized medicine;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;information gathering;Inherited;inhibitor;Investigational Therapies;Life;Malignant - descriptor;microphysiology system;Modeling;Modification;Monitor;Mutation;Operative Surgical Procedures;out-of-hospital cardiac arrest;partial response;patient derived induced pluripotent stem cells;Patient Recruitments;patient response;Patient Selection;Patients;Pediatric Hospitals;Phase;Phosphotransferases;precision medicine;Precision therapeutics;predicting response;Prediction of Response to Therapy;Prevalence;programs;prospective;Protocols documentation;Randomized;randomized placebo controlled trial;Rare Diseases;recruit;Regimen;Reporting;response;Risk;Ryanodine Receptor Calcium Release Channel;standard of care;synergism;Testing;Therapeutic;therapeutic development;therapeutic target;Therapeutic Trials;Time;Tissue Engineering;Tissue Microarray;Tissue Model;Treatment Efficacy;treatment response;trial design;Variant;Ventricular;Ventricular Arrhythmia

PROJECT_TITLE: Tissue chips for precision treatment of catecholaminergic polymorphic ventricular tachycardia


PI_NAMEs: WALLIS-SCHULTZ, DEEANN  (contact)

PROJECT_TERMS: Acceleration;Animal Model;Animal Testing;Animals;Archives;Area;Biochemical;Biocompatible Materials;Bioinformatics;Biological;Biological Assay;Caenorhabditis elegans;ciliopathy;Clinical;clinical center;Collaborations;Communities;Computer software;Consultations;cost;Data;data management;Databases;design;Development;Disease;disease model;distributed model;Ensure;Fee-for-Service Plans;Future;Genetic;Goals;human disease;in vivo Model;Individual;innovation;insight;Intervention;Mission;Mus;Musculoskeletal Diseases;mutant;Neurodevelopmental Disorder;outreach;Pathogenicity;Patients;Phase;Phenotype;pre-clinical;precision medicine;Quality Control;Rattus;repository;Research Personnel;Resources;Rodent;screening;Services;targeted treatment;Therapeutic;therapeutic evaluation;Time;United States National Institutes of Health;Variant;Work;Zebrafish

PROJECT_TITLE: UAB Pilot Center for Precision Animal Modeling (C-PAM) - Resource and Service Section


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Genetics;Human Genome;Neurosciences;Physical Activity;Prevention

PHR: Project Narrative  Aging and related neurodegenerative diseases such as Alzheimer's disease (AD) are an escalating major health concern in the US. The proposed research will examine the molecular 4D nucleome changes that occur in human hippocampus during the course of aging, and the positive effects of physical activity. The proposed research will produce multi-omics cell atlases of the human hippocampus to delineate molecular profiles of normal aging, and uncover potential transcriptional regulatory programs that are impacted by aging.

PI_NAMEs: REN, BING ;XU, XIANGMIN  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Affect;Age;age group;Age Months;age related;age related changes;age related neurodegeneration;Age-associated memory impairment;Aging;aging brain;aging related;Alzheimer's Disease;Animals;Architecture;Area;Atlases;Autopsy;Biological Process;Brain;brain cell;brain control;Brain region;Brain-Derived Neurotrophic Factor;Caring;cell type;Cells;Chromatin;Chromatin Structure;Cognitive;cognitive function;cohort;Data;Diet;DNA;DNA Methylation;DNA methylation profiling;Enhancers;epigenome;Exercise;exercise intervention;Exhibits;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;genomic data;Goals;Health;Hippocampus;Human;human data;human old age (65+);human subject;Impaired cognition;improved;Individual;interest;Intervention;Joints;life span;lifestyle factors;Maps;Measures;Medical;Methods;methylome;Molecular;Molecular Profiling;Monitor;mouse model;multiple omics;Mus;neural circuit;neurotrophic factor;new therapeutic target;normal aging;novel;novel strategies;Nuclear;Older Population;Pattern;Persons;Physical activity;Physical Exercise;Population;Process;programs;promoter;Regulation;Research;Resolution;response;Role;Running;Sampling Studies;sedentary;single cell analysis;single cell genomics;Smoking;Testing;tool;transcriptome;Uncertainty;United States;wearable device;Work

PROJECT_TITLE: Single-Cell Analysis of Aging-Associated 4D Nucleome in the Human Hippocampus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(70)R]


NIH_SPENDING_CATS: Genetics;Precision Medicine

PI_NAMEs: KESTERSON, ROBERT A (contact)

PROJECT_TERMS: Alleles;Animal Disease Models;Animal Model;animal model development;Area;Biochemical;Bioinformatics;Biological;Caenorhabditis elegans;Cardiovascular Diseases;Cell Physiology;ciliopathy;Clinical;clinical center;Clinical Sciences;Communities;cost;cost effective;Data Scientist;Development;Disease;disease model;Disease Pathway;Drug Screening;experience;Functional disorder;Funding Opportunities;gene function;Generations;Genes;Genetic;Genetic Models;genetic resource;Genetic Screening;genetic selection;Genetic Structures;Genetic study;genetic variant;Genetic Variation;Goals;House mice;Human;Immune System Diseases;In Vitro;in vivo;in vivo Model;innovation;insight;Institute of Medicine (U.S.);Institution;interest;Intervention;loss of function mutation;model development;model organism;Modeling;Molecular;Mus;Musculoskeletal Diseases;Mutagenesis;mutant;Mutation;Nervous System Disorder;Neurodevelopmental Disorder;new technology;novel;novel therapeutics;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Physiological;Play;pre-clinical;precision medicine;Preclinical Testing;Production;Rattus;Rattus norvegicus;repaired;Research;Research Personnel;Resources;Rodent;Rodent Model;Role;screening;Series;Services;Standardization;Technology;Testing;Therapeutic;therapeutic evaluation;Time;Translational Research;treatment center;United States National Institutes of Health;Variant;variant of interest;Vision;Zebrafish

PROJECT_TITLE: UAB Pilot Center for Precision Animal Modeling (C-PAM) - Disease Modeling Unit


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Microbiome;Prevention

ORG_CITY: SEATTLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE People living with HIV are at higher risk for severe COVID-19, hospitalization, and mortality, but the immune mechanisms contributing to the enhanced disease are unclear. This project will investigate the role of HIV-related dysregulation of immune responses and the microbiome on SARS-CoV-2 disease using a nonhuman primate model of HIV/AIDS. This innovative study will contribute to our understanding of how normal immunity drives SARS-CoV-2 lung pathophysiology and how immunodeficiencies promote enhanced COVID-19 disease.

PI_NAMEs: O'CONNOR, MEGAN A (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: 16S ribosomal RNA sequencing;2019-nCoV;Acceleration;ACE2;Acute;adaptive immunity;Affect;Alveolar Macrophages;Animals;antiviral drug development;associated symptom;Automobile Driving;B-Lymphocytes;Cells;Cessation of life;co-infection;comorbidity;COVID-19;COVID-19 prevention;COVID-19 severity;COVID-19 vaccination;Disease;Disease Outcome;Disease Progression;dysbiosis;Enteral;Enterocytes;Epithelial Cells;Evolution;exhaustion;extracellular;Frequencies;Functional disorder;gastrointestinal;Gastrointestinal tract structure;Generations;high risk;HIV;HIV Infections;HIV/AIDS;Homeostasis;Hospitalization;Humoral Immunities;Immune;immune activation;Immune response;Immune System Diseases;Immunity;Immunocompromised Host;immunodeficiency;immunopathology;Immunosuppression;Impairment;Individual;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;innovation;insight;Intestines;Link;Lung;lung microbiome;Macaca nemestrina;Macrophage;Measures;microbial;microbial community;microbiome;microbiome composition;Modeling;monocyte;mortality;mucosal site;Mucous Membrane;neutrophil;nonhuman primate;oral commensal;Outcome;Pathogenesis;Pathologic;Persons;Phase;Play;Proteobacteria;Pulmonary Inflammation;Pulmonary Pathology;receptor;rectal microbiome;Rectum;respiratory;respiratory pathogen;Respiratory System;response;Risk;Risk Factors;Risk Reduction;Role;SARS-CoV-2 antiviral;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;SARS-CoV-2 variant;severe COVID-19;Severity of illness;SIV;T cell response;Testing;variants of concern;Viral;Viral hepatitis;Viral Load result;viral transmission;Virulent;Virus;Virus Diseases;Virus Shedding;Work

PROJECT_TITLE: Mechanisms of SARS-CoV-2 pathogenesis during HIV/SIV infection


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Depression;Digestive Diseases;Mental Health;Mental Illness;Microbiome;Neurosciences;Pediatric

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: Narrative Functional gastrointestinal disorders (FGIDs) are common, costly, cause significant pain and distress and yet are often ineffectively treated because they remain poorly understood. Our published and preliminary data strongly support the ideas that: (1) selective serotonin reuptake inhibitor (SSRI) antidepressant exposure in pregnancy is a major unexplored contributor to FGIDs in children and (2) that a serotonin-producing microbiota enterotype that is highly linked to FGID onset is transferrable from adult to child where it continues to drive elevated 5-HT signaling. This proposal will test whether SSRI antidepressant exposure impacts GI function triggering pathology consistent with FGID diagnoses and whether 5-HT producing microbiota provide a synergistic mechanism for these associations.

PI_NAMEs: MARGOLIS, KARA GROSS (contact);SAVIDGE, TOR C.;TAKSER, LARISSA ;TALATI, ARDESHEER

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: 17 year old;Address;Adult;Age;Animals;antagonist;anti-depressive agents;Behavioral;Biological Markers;Biology;Birth;Blood;Brain;Child;Clinical Management;Cohort Studies;cost;cost effective;Coupled;Data;Denmark;Development;Diet;disorder risk;Distress;DNA sequencing;Educational workshop;Exhibits;Exposure to;Feces;fetal;Foundations;Functional Gastrointestinal Disorders;Funding;gastrointestinal disorder diagnosis;gut microbiome;gut microbiota;Home environment;Homeostasis;Human;Impairment;improved;Individual;infancy;Infant;Infrastructure;innovation;Life;Link;Long-Term Effects;Longitudinal Studies;Mass Spectrum Analysis;maternal depression;maternal microbiome;maternal microbiota;Measures;Meconium;Mediating;Mental Health;Methods;microbial;microbiome;microbiota;Modeling;Moods;Morbidity - disease rate;Mothers;motility disorder;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;nervous system development;neurodevelopment;Newborn Infant;novel;offspring;Onset of illness;Outcome;Pain;Pathology;Perinatal;Phenotype;Population;Population Study;postnatal;Pregnancy;prenatal;prospective;Prospective Studies;Public Health;Publishing;Risk;Risk Factors;Role;Rome;sample collection;Selective Serotonin Reuptake Inhibitor;Serotonin;Signal Pathway;Signal Transduction;stool sample;Stress;symptomatology;Symptoms;Testing;therapeutic target;Time;Toddler;transmission process;Woman

PROJECT_TITLE: A Prospective Study Examining the Role of Gestational SSRI Exposure in the Development of Functional Gastrointestinal Disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Heart Disease;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_DEPT: GENETICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Narrative. Friedreich’s ataxia (FA) is a common, fatal hereditary disorder associated with devastating clinical manifestations. While neurologic disease limits mobility, 60% of individuals with FA die from progressive cardiomyopathy. The goal of this R61/R33 proposal is to carry out a phase IA/IB clinical study of AAVrh.10hFXN (a serotype rh.10 adeno-associated virus coding for human frataxin) to reverse cardiac manifestations of Friedreich’s ataxia.

PI_NAMEs: CRYSTAL, RONALD G (contact);KAMINSKY, STEPHEN MICHAEL;WEINSAFT, JONATHAN W.

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Adverse event;Affect;Arrhythmia;Ataxia;Automobile Driving;Biological Markers;Capsid;Cardiac;cardiac magnetic resonance imaging;Cardiomyopathies;Cessation of life;Clinical;Clinical Research;Clinical Trials;Code;Complementary DNA;coronary fibrosis;Data;Dependovirus;Development;Disease;DNA cassette;Dose;Drug Packaging;Early identification;Echocardiography;efficacy study;Electrocardiogram;Enrollment;Experimental Animal Model;Fibrosis;frataxin;Friedreich Ataxia;Gene Expression;gene transfer vector;Genes;Genetic;Genome;Goals;Heart;Heart failure;Hereditary Disease;Human;human study;Hypertrophy;improved;Individual;Inherited;inherited cardiomyopathy;Institutional Review Boards;Intravenous;intravenous administration;Introns;Investigational Drugs;Left;Left Ventricular Dysfunction;Left Ventricular Hypertrophy;Left Ventricular Remodeling;Life;Link;manufacture;manufacturing process;Mediating;Mitochondria;Monitor;Morbidity - disease rate;mouse model;Myocardial;Myocardial tissue;Nervous System Disorder;nonhuman primate;open label;Outcome;Outpatients;Parents;Patients;Phase;Phase Ia/Ib Clinical Trial;Phenotype;preclinical efficacy;preservation;Procedures;Production;promoter;Protocols documentation;Quality Control;Records;Reporting;Risk;Route;Safety;safety assessment;Secondary to;Serotyping;Serum;Statistical Data Interpretation;Therapeutic;therapeutic gene;Time;Toxicology;Variant;vector;Ventricular

PROJECT_TITLE: Phase IA/IB Study of AAVrh.10hFXN Therapy to Treat the Cardiomyopathy of Friedreich's Ataxia


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_NAME: POPULATION COUNCIL

PHR: P50 Project Narrative The Population Council P50 Contraception Development Research Center aims to develop a new vaginal ring without any hormones that will prevent pregnancy and that may better meet the needs of many women around the world. The prevention of unintended pregnancy is a public health priority with approximately half of all pregnancies in the world being unintended. As a significant added benefit, this new contraceptive will also protect women from sexually transmitted infections, which continue to occur at high rates and cause problems in women such as infertility, premature delivery of babies, and increased risk of HIV.

PI_NAMEs: HADDAD, LISA BLAKE (contact)

PROGRAM_OFFICER_NAME: LINDSEY, CHRISTOPHER CHARLES

PROJECT_TERMS: Adherence;Advanced Development;Advisory Committees;AIDS prevention;Anti-Bacterial Agents;antimicrobial;Bacterial Vaginosis;Basic Science;Behavioral Sciences;Biomedical Research;candidate selection;career;Characteristics;Child Health;Chlamydia;chronic pelvic pain;Clinical Trials;collaborative environment;combat;community engagement;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;Copper;Cross-Over Studies;Cross-Sectional Studies;Data;design;Development;Development Plans;Dimensions;Dose;Drug Delivery Systems;Drug Kinetics;Ensure;Evaluation;experience;experimental study;Failure;Fellowship;Formulation;Fostering;Funding;Goals;Gonorrhea;Good Manufacturing Process;Grant;Health;health goals;HIV;HIV-1;Hormones;Human;Human Herpesvirus 2;improved;In Vitro;in vivo;Industry;Infertility;innovation;Institution;interest;Investigational Drugs;Investments;Lactic acid;Lead;Macaca mulatta;manufacture;Marketing;Maternal and Child Health;Maternal Mortality;Mechanics;Medical;Menstruation;Methods;National Institute of Child Health and Human Development;novel;Pathway interactions;Performance;Persons;Pharmacologic Actions;Pharmacologic Substance;Pilot Projects;Polymers;Population;preclinical study;Pregnancy;Premature Birth;prevent;Prevention;Prevention Research;Prodrugs;product development;Production;Property;prototype;public health priorities;Regulatory Affairs;Reproductive Health;Research;research and development;Research Personnel;Research Project Grants;Risk;Safety;safety study;Science;sensor;Sexually Transmitted Diseases;Sheep;Side;Social Sciences;sperm cell;success;synergism;Technology;technology development;Temperature;Testing;timeline;Toxic effect;unintended pregnancy;Vagina;Vaginal Ring;Viral;Woman;Women's Health;Work;Zinc;Zinc Acetate

PROJECT_TITLE: Contraception development research center to advance a novel intravaginal ring as a non-hormonal multipurpose prevention technology


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

PROJECT_TERMS: Address;Advanced Development;Advisory Committees;Agreement;AIDS prevention;Behavioral Sciences;Biomedical Research;Budgets;career;Clinic;Clinical Sciences;Clinical Trials;Collaborations;Communication;community advisory board;Complex;Contraceptive Agents;Contraceptive methods;Copper;Counseling;Data;data management;design;Ensure;Environment;experience;Formulation;Fostering;Funding;Goals;Grant;Health;Heart;HIV/STD;industry partner;Infrastructure;innovation;Knowledge;Lactic acid;Lead;Leadership;manufacture;Mentorship;Monitor;multidisciplinary;Multiple Partners;National Institute of Child Health and Human Development;novel;Occupational activity of managing finances;Pathway interactions;Population;Prevention;Process;Prodrugs;product development;Productivity;programs;Regulatory Affairs;research and development;Research Personnel;Research Priority;Resource Allocation;Science;Scientist;Services;skills;Social Sciences;Strategic Planning;Talents;Technology;Testing;timeline;Training;training opportunity;U-Series Cooperative Agreements;USAID;Vagina;Vaginal Ring;Veterans;Woman;Work;Zinc

PROJECT_TITLE: Population Council Contraception Development Research Center Administrative Core


ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: This proposal will characterize the role of mitochondrial unfolded protein response in prostate cancer progression leading to aggressive disease. The proposed research will define the underlying mechanism of mitochondrial regulation of therapeutic resistance and its translational relevance in prostate cancer. The successful completion this study will provide alternative treatment options for men with this lethal prostate cancer.

PI_NAMEs: CHANDRA, DHYAN  (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: activating transcription factor;Address;alternative treatment;androgen independent prostate cancer;androgen sensitive;Androgens;Apoptosis;Attenuated;cancer cell;cancer subtypes;Caspase;Cell Nucleus;Cell Proliferation;Cell Survival;Cells;Chaperonin 60;chromatin immunoprecipitation;clinically relevant;Data;Data Analyses;Development;Disease;docetaxel;enzalutamide;Generations;Genetic;Genetic Engineering;Gleason Grade for Prostate Cancer;Human;Hypoxia;Immune response;immunogenic cell death;in silico;in vivo;Inhibition of Apoptosis;inhibitor;Knock-out;Knockout Mice;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;men;Metabolic;Mitochondria;Mitochondrial Proteins;neoplastic cell;neuroendocrine phenotype;novel;novel therapeutics;Organoids;overexpression;patient derived xenograft model;Patients;Primary Neoplasm;Production;Prognosis;promoter;prostate cancer cell;prostate cancer progression;prostate carcinogenesis;Prostatic Neoplasms;Prostatic Tissue;Proteins;proteostasis;Reactive Oxygen Species;Regulation;Reporter;Research;Resistance;Resistance development;response;Role;Signal Transduction;standard of care;Stress;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Uses;therapy outcome;therapy resistant;transcription factor;Treatment Efficacy;tumor;Tumor Burden;tumor growth;tumor progression;tumorigenesis

PROJECT_TITLE: Hsp60 Regulation of Prostate Cancer Progression

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Contraception/Reproduction;Infectious Diseases;Prevention;Sexually Transmitted Infections;Topical Microbicides;Women's Health Research

PI_NAMEs: VARIANO, BRUCE F (contact)

PROJECT_TERMS: Adherence;Advanced Development;AIDS prevention;analytical method;Anti-Bacterial Agents;Bacterial Vaginosis;Biological Assay;Characteristics;Chlamydia;clinical efficacy;Collaborations;Contraceptive Agents;Contraceptive methods;Copper;cost efficient;Data;design;Development;Dimensions;Documentation;Dose;Evaluation;expectation;experience;Failure;flexibility;Formulation;Geometry;Goals;Gonorrhea;Health;health goals;Healthcare;HIV;HIV-2;HIV/STD;Human;Human Herpesvirus 2;In Vitro;in vitro testing;Infection;Ions;Lactic acid;Lead;lead candidate;Macaca mulatta;manufacture;manufacturing process;manufacturing scale-up;Marketing;Measures;Mechanics;medical schools;meetings;metallicity;Methods;Modeling;Molds;multidisciplinary;new technology;novel;Pathway interactions;Performance;Pharmacologic Substance;Polymers;Population;Positioning Attribute;pre-clinical;preference;Pregnancy;prevent;Prevention;Prodrugs;Property;prototype;public health intervention;Qualifying;quality assurance;Quality Control;Regimen;Reproductive Health;Research;research and development;research clinical testing;Research Project Grants;Residual state;Role;safety testing;Salts;scale up;Scientist;Self Care;sensor;sexual and reproductive health;Sexual Transmission;Sexually Transmitted Diseases;Sheep;Silicone Elastomers;social;Source;Specific qualifier value;Spermatocidal Agents;stability testing;Technology;Technology Transfer;Temperature;Testing;tool;Universities;Vagina;vaginal infection;Vaginal Ring;Viral;Viral Physiology;Woman;Zinc

PROJECT_TITLE: Formulation development and testing of a novel non-hormonal intravaginal ring to prevent pregnancy and sexually transmitted infections


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Duchenne/ Becker Muscular Dystrophy;Genetics;Heart Disease;Human Genome;Muscular Dystrophy;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Project Narrative The psychological and socioeconomic effects of DMD on families are enormous. These include medical care costs, opportunity costs for career and work, and the psychological toll taken on parents and siblings. The identification of genetic modifiers of DMD will allow for patient stratification in upcoming clinical trials of novel therapies, may reveal novel targets for potential therapies, and may allow patient-specific tailoring of current therapies.

PI_NAMEs: FLANIGAN, KEVIN M (contact);VIELAND, VERONICA J.;WEISS, ROBERT B

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: 20 year old;Affect;Age;age effect;Archives;Award;Becker Muscular Dystrophy;Birth;C-terminal;Candidate Disease Gene;Cardiac;Cardiomyopathies;career;Cessation of life;Clinical;Clinical Trials;cohort;Collaborations;coronary fibrosis;Data;Databases;density;Deoxyribonucleases;Diagnosis;disability;Disease;Disease Progression;DNA;Duchenne muscular dystrophy;Dystrophin;dystrophinopathy;Engineering;Enrollment;Europe;exon skipping;Exons;Family;Fatty acid glycerol esters;Fibrosis;First Independent Research Support and Transition Awards;Funding;Future;Gene Modified;Gene Mutation;gene therapy;Genes;Genetic;Genetic Polymorphism;genome-wide;genomic data;Genomic Segment;Genotype;Goals;Grant;heart function;Hi-C;Hypersensitivity;in silico;Link;Magnetic Resonance Imaging;male;Maps;Measures;Medical Care Costs;Methods;micro-dystrophin;Modeling;Molecular;Morbidity - disease rate;Mus;Muscle;Muscle Fibers;Muscular Dystrophies;Mutation;Myopathy;Natural History;Necrosis;novel;novel strategies;novel therapeutics;Open Reading Frames;opportunity cost;Outcome;Parents;participant enrollment;Pathway interactions;patient stratification;Patients;Phenotype;phenotypic data;preservation;Principal Investigator;programs;promoter;Proteins;psychologic;pulmonary function;Quantitative Trait Loci;Recontacts;Records;Research;Research Personnel;Resources;Sampling;Severities;Severity of illness;Siblings;Signal Transduction;Single Nucleotide Polymorphism;Site;Skeletal Muscle;SNP array;SNP genotyping;socioeconomics;Testing;Therapeutic Intervention;therapy outcome;Thrombospondin 1;trait;United States National Institutes of Health;Update;Validation;validation studies;Variant;Walking;Work

PROJECT_TITLE: Genetic modifiers of Duchenne Muscular Dystrophy

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Complementary and Integrative Health;Dietary Supplements;Hypertension;Natural Products;Nutrition;Prevention

ORG_CITY: FOREST GROVE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PACIFIC UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE It is estimated that high blood pressure affects nearly 75 million persons, contributes to the death of over 410,000 Americans each year, and results in more than $51.2 billion in annual treatment costs. Due to high treatment costs, adverse side effects of existing drugs, and high risk of drug-drug interactions, only approximately 50% of adults with hypertension have their blood pressure adequately controlled. This project seeks to investigate isothiocyanates (ITCs), natural products derived from cruciferous vegetables as a cheaper alternative to effectively treat or protect against hypertension with minimal side effects and minimal risk of drug interactions.

PI_NAMEs: ELBARBRY, FAWZY  (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Acetylcholinesterase;Acids;Address;Adult;Adverse effects;Affect;Affinity;allyl isothiocyanate;American;American Heart Association;analog;Angiotensin II;Animal Model;Anti-Hypertensive Agents;Antiinflammatory Effect;Antioxidants;Arachidonic Acids;Arteries;benzyl isothiocyanate;Binding;Biological Assay;Biological Availability;Blood Pressure;blood pressure elevation;blood pressure reduction;Brassica;Broccoli - dietary;Cabbage - dietary;Cardiovascular Diseases;cardiovascular risk factor;Cauliflower;Cause of Death;Central Nervous System;Cessation of life;Chemoprevention;Chronic;Clinical Sciences;Consumption;Coronary heart disease;cost;cruciferous vegetable;Cytochrome P450;Cytosol;Death Rate;Development;Diet;dietary;Docking;Doctor of Pharmacy;Dose;Drug Interactions;Drug Kinetics;Effectiveness;Endothelium;Enrollment;Enzymes;Epoxide hydrolase;Epoxy Compounds;Family;Fatty Acids;Female;Fluorescence;Food;Functional disorder;Goals;graduate student;Healthcare;Heart;high risk;Horseradish;Human;Hypertension;hypertensive;improved;in vivo;Inbred SHR Rats;Incidence;Incubated;Individual;Inflammation;inhibitor;Isothiocyanates;Kale - dietary;Kidney;kidney vascular structure;Kinetics;Laboratories;Lepidium sativum;Liver;male;Measures;minimal risk;Modeling;Molecular;Monophenol Monooxygenase;Morbidity - disease rate;mortality;Mustard;Natural Products;Nature;novel;Oral;Oxidative Stress;Pathogenesis;Patients;Persons;Pharmaceutical Preparations;pharmacokinetic characteristic;pharmacologic;Phenethyl Isothiocyanate;Plants;Play;Population;prevent;Probability;Property;Rattus;Readiness;Recombinants;Regulation;Research;Research Infrastructure;Research Training;Resources;Risk;Role;side effect;skills;Sodium Chloride;Stroke;structural determinants;Students;Sulforaphane;Testing;Therapeutic;therapeutic target;Tissues;training opportunity;Treatment Cost;Uncertainty;undergraduate student;Uninsured;United States;Universities;Vegetables;Watercress

PROJECT_TITLE: Antihypertensive Effect of Food-Origin Isothiocyanate Soluble Epoxide Hydrolase Inhibitors


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Social Determinants of Health;Telehealth

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PURDUE UNIVERSITY

PHR: PROJECT NARRATIVE Drastic shifts in family and community life associated with the spread of COVID-19 have been especially challenging for families of children with neurogenetic conditions (NGC), who are particularly vulnerable to reductions in targeted therapeutic services, and whose children are more likely to experience increases in challenging behavior as a result of the changes. The proposed study will test the feasibility, efficacy, and impact of a personalized digital assessment and treatment network for reducing secondary health effects of COVID-19 on NGC caregivers.

PI_NAMEs: KELLEHER, BRIDGETTE LYNNE (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Acceleration;Acute;Address;Algorithms;Award;Behavior;Behavior Therapy;Black race;Caregiver Burden;Caregiver support;Caregivers;caregiving;Caring;Cellular Phone;Child;Child Care;Child Rearing;Clinic;Clinical;clinically significant;Communication;Communities;compare effectiveness;Complex;cost effective;cost efficient;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;current pandemic;Data;design;Diagnostic;digital assessment;digital delivery;digital health;digital healthcare;digital intervention;digital mental health;digital treatment;Distress;Ecological momentary assessment;Education;Effectiveness;efficacy testing;Emergency Situation;Epidemic;evidence base;Evidence based intervention;Evidence based treatment;experience;Face;Family;feasibility testing;Financial Hardship;first responder;Fright;Frontline worker;Frustration;Functional impairment;Future;Geography;graduate student;Health;health disparity;Health Services Accessibility;Healthcare;high risk;high risk population;Infrastructure;innovation;Intervention;Life;Longitudinal Studies;Medical;meetings;Mental Health;Methods;Minority;Modeling;Monitor;motivational enhancement therapy;neurogenetics;novel;Outcome;pandemic disease;pandemic impact;Participant;Patients;peer;peer coaching;personalized medicine;physical conditioning;post-traumatic stress;pre-pandemic;prevent;Protocols documentation;Provider;Public Health;Questionnaires;Race;Randomized;response;Risk;Route;scale up;Self Efficacy;Series;service intervention;Services;smartphone application;Social Distance;Social isolation;Stress;Symptoms;Syndrome;targeted treatment;teacher;telehealth;therapy design;tool;Training;Trauma;treatment as usual;Triage;Underserved Population;uptake;vector;virtual;Vocation;Vulnerable Populations;Work

PROJECT_TITLE: Optimizing a Personalized Health Approach for Virtually Treating High-Risk Caregivers During COVID-19 and Beyond

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-M(54)R]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Infectious Diseases;Microbiome;Prevention;Sexually Transmitted Infections;Topical Microbicides;Women's Health Research

PI_NAMEs: TELESHOVA, NATALIA  (contact)

PROJECT_TERMS: Adherence;Advanced Development;Advisory Committees;AIDS prevention;Andrology;Animals;Anti-Bacterial Agents;Anti-Infective Agents;antimicrobial;Area;Bacteria;Bacterial Vaginosis;Biological Response Modifiers;Biology;Blood;Calibration;Cells;Cervical;cervicovaginal;Cervix Mucus;Chemicals;Chlamydia;Clinical;Clinical Trials;Collaborations;college;combat;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;Copper;Copper Sulfate;cost;Data;design;Development;dosage;Dose;Drug Kinetics;efficacy testing;Evaluation;Female Condoms;Formulation;Goals;Gonorrhea;Health;Histology;HIV;HIV-1;Hormonal;hormonal contraception;Human;Human Herpesvirus 2;Immune;improved;In Vitro;in vitro activity;in vitro testing;in vivo;in vivo evaluation;innovation;Ions;Lactic acid;Lactobacillus;Lead;lead candidate;Macaca mulatta;Male Condoms;Methods;microbiota;Motility;multidisciplinary;Mus;novel;Oryctolagus cuniculus;Penetration;Pharmaceutical Preparations;Pharmacologic Substance;Population;Positioning Attribute;pre-clinical;pre-Investigational New Drug meeting;Preclinical Testing;Pregnancy;pregnancy prevention;prevent;Prevention;Prodrugs;product development;prototype;public health intervention;Qualifying;Research;research and development;Research Personnel;Research Project Grants;rRNA Genes;Safety;safety assessment;Seminal Plasma;Sexually Transmitted Diseases;Sheep;side effect;Simplexvirus;skills;sperm cell;STI prevention;Technology;technology development;Testing;Toxic effect;transcriptome;transcriptome sequencing;unintended pregnancy;United States Food and Drug Administration;Universities;uptake;Vagina;vaginal fluid;vaginal microbiota;Vaginal Ring;Viral;Woman;Zinc Acetate

PROJECT_TITLE: Preclinical testing of a novel non-hormonal intravaginal ring to prevent pregnancy and sexually transmitted infections


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Lung;Prevention;Pulmonary Hypertension;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Schistosomiasis is a parasitic infection affecting more than 250 million individuals in many tropical countries, and is a major cause of pulmonary arterial hypertension (PAH) worldwide. How this parasite together with the body’s immune system injure the lung blood vessels to cause PAH is not well understood. Using a series of experiments with mice experimentally exposed to the parasite, along with analysis of blood samples collected from patients with this condition in Brazil, we seek to understand how this happens, and identify new ways to diagnose the disease and potentially prevent it or treat it in the future.

PI_NAMEs: GRAHAM, BRIAN BARKLEY (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: adaptive immunity;Address;Affect;Amplifiers;Animal Model;Antigen Presentation;Antigens;Area;Autoimmune Diseases;Automobile Driving;Blood;Blood specimen;Blood Vessels;Brazil;Cardiac Catheterization Procedures;CCL2 gene;CCL7 gene;CD4 Positive T Lymphocytes;cell type;Cells;Circulation;Clinical;clinical center;cohort;Communicable Diseases;Country;cross immunity;cytokine;Dendritic Cells;Development;Diagnosis;diagnostic biomarker;Diagnostic tests;Disease;disease diagnosis;Echocardiography;Equilibrium;Event;experimental study;Exposure to;Foundations;Fractalkine;Future;Helminths;Human;Hypoxia;Immune;Immune system;Immune Tolerance;Individual;Inflammation;Inflammatory;Interleukin-1;interstitial;ITGAM gene;Ligands;Lung;Macrophage;Modeling;monocyte;mouse model;Mus;Natural Immunity;novel diagnostics;novel strategies;Parasites;Parasitic infection;Pathogenesis;Pathology;Patients;Phenotype;Plasma;Plasma Proteins;Population;Populations at Risk;Predisposition;prevent;Proteins;Public Health;pulmonary arterial hypertension;Pulmonary Hypertension;pulmonary vascular disorder;recruit;Resource-limited setting;Risk;Role;Schistosoma;Schistosomiasis;screening;Series;Source;Specimen;Sterility;SU 5416;T-Cell Activation;Testing;Thrombospondin 1;Transforming Growth Factor beta;Vaccines;Vascular Diseases;vascular inflammation;Vascular remodeling;Work

PROJECT_TITLE: Activation, Phenotype and Function of CD4 T Cells in Schistosoma-Pulmonary Hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Overall Project Narrative Antiretroviral treatment (ART) options for pregnant women and children living with HIV have fallen behind those for adults, reflecting the substantial research gap for modern ART regimens in these groups. Here we propose a series of interrelated projects that expand the scientific objectives and data utilization of a valuable nationwide birth surveillance system in Botswana (the Tsepamo Study), and connect it with the infrastructure provided by an existing program for identifying and treating infants with HIV (the Early Infant Treatment Study). The four proposed projects, anchored by two cores, include: 1) expanded congenital abnormality surveillance and performance of an emulated clinical trial to address critical questions related to the use of ART regimens by maternal weight strata; 2) creation of surveillance reporting criteria in pregnancy and validation of a target trial approach to ART regimen comparisons; 3) use of Tsepamo data and EIT infrastructure to perform targeted point- of-care HIV testing at birth followed by optimized Dolutegravir-based ART for infants; and 4) utilizing point-of- care diagnostics and the Dolutegravir treatment cohort, and specimens from mRNA vaccine recipients, to support laboratory-based precision medicine approaches for immune control of pediatric HIV infection.

PI_NAMEs: SHAPIRO, ROGER L (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Address;Adult;antiretroviral therapy;Birth;Botswana;Child;chromosomal location;Clinical Trials;cohort;Collaborations;Congenital Abnormality;Data;data management;data sharing;Data Sources;Development;Diagnosis;efficacy study;experience;Exposure to;forging;Funding;high risk infant;HIV;HIV vaccine;HIV-1;Human immunodeficiency virus test;Immune;Immune response;infancy;Infant;Infection;Infrastructure;Laboratories;maternal weight;Measures;Messenger RNA;Methodology;Modernization;neonate;Neural Tube Defects;novel strategies;Outcome;pediatric human immunodeficiency virus;pediatric human immunodeficiency virus infection;Performance;point of care;point-of-care diagnostics;precision medicine;Pregnancy;Pregnant Women;Principal Investigator;programs;Reporting;Research;Research Personnel;Research Priority;RNA vaccine;safety study;Series;Specimen;Surveillance Program;System;Techniques;treatment guidelines;treatment optimization;Treatment Protocols;treatment strategy;United States National Institutes of Health;Validation;Viral reservoir;Weight;Woman;Work

PROJECT_TITLE: Closing Research Gaps in Antiretroviral Treatment for Pregnant Women and Infants Living with HIV


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS

PROJECT_TERMS: antiretroviral therapy;Collaborations;Communication;cost;Data;data management;experience;Fostering;Goals;HIV;Human Resources;Infant;Infrastructure;Institution;Institutional Review Boards;meetings;Monitor;Occupational activity of managing finances;Pregnant Women;Process;Productivity;programs;Reporting;Research;Research Personnel;Resources;skills;success;Teleconferences;timeline;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: RALEIGH

ORG_DEPT: PHYSICS

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: Project Narrative Mistakes in cell division result in cells having extra or missing genetic information, a state which is associated with cancer, miscarriage, and birth defects. The results of this study will provide insight on how components of the machine that segregates genetic information are built, and how their mechanical properties are tuned to ensure that genetic information is segregated accurately when cells divide. In the long run, this approach will potentially suggest new explanations for how disease states related to cell division arise, and new strategies for targeting them.

PI_NAMEs: ELTING, MARY WILLIARD (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;Affect;Architecture;Axon;Biochemistry;Biological Process;Building Codes;Bundling;Cell division;Cells;Chromosome Segregation;Chromosomes;Cilia;Congenital Abnormality;Coupling;Crosslinker;daughter cell;Disease;Engineering;Equilibrium;Fiber;Fission Yeast;flexibility;genetic information;Goals;In Vitro;in vivo;insight;Kinetochores;Lead;Malignant Neoplasms;Maps;Measures;mechanical properties;Mechanics;Microtubule Bundle;Microtubules;Mitotic spindle;Molecular;Molecular Probes;molecular scale;Morphology;novel;programs;Property;reconstitution;response;segregation;self organization;Spontaneous abortion;Stereotyping;Structure;System;Time;tool;transmission process;Work

PROJECT_TITLE: Microtubule bundles in the mitotic spindle: probing how mechanical and functional robustness emerge from molecular architecture

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS

PI_NAMEs: KGATHI, COULSON  (contact)

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Anti-Retroviral Agents;antiretroviral therapy;Birth;Botswana;Child;Clinical Management;Collaborations;COVID-19 vaccine;Data;data anonymization;Data Collection;data dissemination;data management;Data Reporting;Data Set;data sharing;Databases;Dedications;distributed data;electronic data;Ensure;experience;Goals;HIV;Human immunodeficiency virus test;Immune;Infant;Laboratories;Link;Maintenance;Methodology;Mothers;Outcome;Participant;Patients;point of care;Pregnancy;Pregnant Women;Process;Program Research Project Grants;programs;quality assurance;Quality Control;Research;Services;Specimen;Surveillance Program;surveillance study;System

PROJECT_TITLE: Data Management and Distribution Core


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;HIV/AIDS;Infectious Diseases;Maternal Health;Pediatric;Pediatric - AIDS;Pregnancy;Women's Health Research

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adopted;Adult;adverse birth outcomes;Africa;African;Anti-Retroviral Agents;antiretroviral therapy;Award;Birth;Birth Intervals;Botswana;Clinical Trials;Complex;Conceptions;Congenital Abnormality;Country;Data;Databases;dietary;emtricitabine;Evaluation;Exclusion;experience;Folic Acid;Funding;Guidelines;Health;Health Status Indicators;HIV;Hospitals;improved;Incidence;Individual;Infant;Intake;International;Lamivudine;Link;maternal hypertension;maternal weight;Modeling;Modernization;Multiple Pregnancy;Neonatal Mortality;Neural Tube Defects;novel;Outcome;Patients;Pattern;pre-exposure prophylaxis;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;Prevalence;Productivity;Program Research Project Grants;programs;Publications;Rain;randomized, clinical trials;Regimen;Reporting;Research;Resource-limited setting;Risk;Safety;Seasons;secondary analysis;Site;Small for Gestational Age Infant;stillbirth;surveillance study;System;Tenofovir;Time;timeline;treatment guidelines;treatment program;Treatment Protocols;trial comparing;Update;Weight;Weight Gain;Woman

PROJECT_TITLE: Tsepamo Plus: Expanded Congenital Abnormalities Surveillance with an Emulated Clinical Trial to Evaluate Weight Impact on Birth Outcomes for Newer ART Regimens


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

PI_NAMEs: FRIEDLAND, BARBARA A (contact)

PROJECT_TERMS: Address;Adherence;Age;aged;Anti-Bacterial Agents;arm;Attitude;Bacterial Vaginosis;Behavior;Behavioral Research;Benefits and Risks;Biological Markers;Body Temperature;Characteristics;Clinical;Clinical Trials;Coitus;Collaborations;Compressive Strength;Contraceptive Agents;Contraceptive methods;Copper;Cross-Over Studies;Cross-Sectional Studies;Data;Data Reporting;Defecation;design;Development;Dose;Esthesia;Evaluation;Excision;Exercise;experience;experimental study;Formulation;Future;Goals;Health;health goals;Hormones;Intention;Interview;male;Measurement;Measures;Mechanics;meetings;Menstruation;Methods;National Institute of Child Health and Human Development;novel;Nulliparity;older women;open label;parity;parous;Participant;Pathway interactions;Patient Self-Report;Pattern;Perception;Performance;Personal Satisfaction;Pharmacologic Substance;physical property;Planning Theory;Population;Preclinical Testing;preference;Pregnancy;prevent;Prevention;product development;prototype;Questionnaires;Randomized;Regimen;Reporting;reproductive;Reproductive Health;Research;research and development;Research Project Grants;Risk;Running;sensor;Sex Behavior;sexually active;Sexually Transmitted Diseases;sociodemographics;Sorting;STI prevention;Structure;Surveys;Technology;Temperature;Text Messaging;Time;tool;unintended pregnancy;Universities;uptake;Vagina;Vaginal Ring;Visit;Walking;Woman;Zinc

PROJECT_TITLE: Investigating end-user perspectives to inform the development of a novel non-hormonal intravaginal ring to prevent pregnancy and sexually transmitted infections


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Complementary and Integrative Health;Dietary Supplements;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Nutrition;Pediatric;Prevention

ORG_CITY: Aurora

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project narrative Dysfunctional maturation of GABAergic neurotransmission and excitatory/inhibitory [E/I] balance in the brain is implicated in several neurodevelopmental disorders. Identification of the ontogenic, molecular, cellular and circuit mechanisms is crucial for understanding childhood social, cognitive and anxiety disorders and for the identification of intervention and treatment advances. Neuregulin 1 (NRG1), and CHRNA7 [15q13.3] (encoding the a7nAChR) are key modulators of nervous system development. Signaling via the a7nAChR is a critical driver of the GABA excitatory/inhibitory [E/I] shift, mediated via the chloride transporters, NKCC1 and KCC2. Here we will use a novel transgenic mouse model of NRG1 overexpression, molecular biology, cell biology, slice electrophysiological approaches and behavioral neuroscience to examine the role of a novel NRG1 isoform on brain development (spanning from birth to adulthood) as it mechanistically relates to cortical maturation of GABA transmission and E/I balance, neurobehavior. The project will also provide mechanistic data and identify prenatal intervention strategies to improve brain development in-utero.

PI_NAMEs: LAW, AMANDA JAYNE (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Adult;Agonist;Alleles;alpha-bungarotoxin receptor;Anxiety;Anxiety Disorders;ARHGEF5 gene;Attenuated;autism spectrum disorder;Behavior;Behavioral;Biological;Birth;Brain;Calcium;Candidate Disease Gene;CDK6-associated protein p18;Cells;Cellular biology;Childhood;Chlorides;Choline;choline supplementation;Cognition;Cognition Disorders;cognitive function;Crossbreeding;Data;Development;Developmental Disabilities;developmental disease;dietary;Dietary Supplementation;Electrophysiology (science);Engineering;Equilibrium;experimental study;gamma-Aminobutyric Acid;Gene Expression Profiling;Gene Modified;Genes;Genetic;Genetic Polymorphism;genetic risk factor;Genetic Transcription;Growth;Hippocampus;Human;Immunofluorescence Immunologic;Immunohistochemistry;improved;in utero;Individual;Intervention;Investigation;knock-down;Knowledge;Link;Long-Term Effects;Maps;Mediating;Memory;microdeletion;Molecular;Molecular Biology;mouse model;multidisciplinary;Mus;mutant;neocortical;Neonatal;nervous system development;Neuregulin 1;Neuregulins;neurobehavior;neurobehavioral;neurobiological mechanism;neurodevelopment;Neurodevelopmental Disorder;Neurons;neurophysiology;Neurosciences;neurotransmission;Neurotransmitters;next generation sequencing;Nicotinic Receptors;novel;Nutrient;Outcome;overexpression;Pathogenesis;Pathway interactions;Persons;Phase;Phenotype;preclinical trial;Pregnancy;prenatal;prenatal intervention;prevent;primary outcome;promoter;Protein Isoforms;Regulation;Reproducibility;Research;Risk;Rodent;Role;Sensory;Signal Pathway;Signal Transduction;Slice;social;social deficits;Social Discrimination;Social Interaction;sodium-potassium-chloride cotransporter 1 protein;Structure;Supplementation;symporter;Syndrome;Testing;Time;transcriptome sequencing;Transgenic Mice;transmission process

PROJECT_TITLE: Neuregulin/Alpha7nAChR Signaling, the GABAergic Switch and Neurodevelopmental Risk: Mechanisms of Gestational Choline Supplementation.

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative The elderly have impaired capabilities to regulate their internal temperature, resulting in this population being particularly susceptible to injuries and death during heat waves. This project seeks to identify and mitigate the effects of aging on adverse thermal and cardiovascular responses during heat wave conditions.

PI_NAMEs: CRANDALL, CRAIG G (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acceleration;Activities of Daily Living;Address;Adverse effects;age effect;age group;Aging;Air;Air Conditioning;American;Attenuated;Body Temperature;Cardiovascular Physiology;Cardiovascular system;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chicago;cost;Coupled;COVID-19;current pandemic;Data;Death Rate;Dryness;efficacy evaluation;Elderly;Electricity;Encapsulated;Exhibits;Experimental Models;Exposure to;Frequencies;future pandemic;Generations;global temperature;Government;Heat Stress;Heat Stress Disorders;Heat Waves;Heating;Home;Household;Human;Humidity;Hyperthermia;Impairment;Individual;indoor air;Industry;Injury;Libraries;Literature;Los Angeles;Low Income Population;Metabolic;Midwestern United States;Modality;Morbidity - disease rate;mortality;Outcome;pandemic disease;Perfusion;Physiological;Population;Predisposition;prevent;Quarantine;Reporting;response;Risk;Shapes;Skin;Socioeconomic Status;socioeconomics;Stress;Temperature;Testing;Time;United States;Vulnerable Populations;Water;Work;young adult

PROJECT_TITLE: Heat waves and the elderly: reducing thermal and cardiovascular consequences

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;HIV/AIDS;Infectious Diseases;Maternal Health;Pediatric;Pediatric - AIDS;Pregnancy;Prevention;Women's Health Research

PI_NAMEs: SWANSON, SONJA ALSEMGEEST (contact)

PROJECT_TERMS: African;antiretroviral therapy;Benchmarking;Birth;Botswana;Calibration;Clinical;cohort;Computer software;cost;Country;Data;Databases;Decision Making;Future;Guidelines;HIV;improved;Infant;Influentials;Interdisciplinary Study;Methodology;Methods;mother nutrition;Multiple Pregnancy;Neural Tube Defects;novel;Observational Study;Outcome;Pregnancy;Pregnancy Outcome;Pregnant Women;premature;Probability;Procedures;Program Sustainability;Property;Protocols documentation;randomized trial;Recommendation;Regimen;Reporting;Research;Research Design;Safety;Sample Size;Sampling;Signal Transduction;Statistical Data Interpretation;stillbirth;study population;Subgroup;surveillance data;surveillance study;System;Techniques;Testing;Uncertainty;unethical;Weight Gain;Woman

PROJECT_TITLE: Methodology: Developing Reporting Criteria for Pregnancy Surveillance Cohorts and New Techniques for Supporting Target Trials


NIH_SPENDING_CATS: Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

PHR: Inflammatory breast cancer (IBC), a highly lethal form of breast cancer, disproportionately affects African American (AA) compared with non-Hispanic White women (W) with hazard ratios for death 30% higher in AA compared to W even after adjusting for socioeconomic position, age at diagnosis, treatment, and hormone receptor status. Recently, we discovered that this disparity may be the result of a heightened adaptive stress response signaling in the tumor microenvironment of AA linked to IBC risk factors, which can lead to greater capacity for clonal evolution of death-resistant tumor cells contributing to aggressive, therapy-resistant disease. As the incidence is rising and targets for therapy are scant, IBC has the potential to become a major public health disparity concern. This study has the potential to lead to new treatment options, provide a biomarker for stress related progression and therapy resistance in AA-IBC, and predict those who would benefit from these targeted approaches.

PI_NAMEs: DEVI, GAYATHRI  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Address;Affect;African American;African ancestry;Age;aggressive breast cancer;Apoptosis;Apoptotic;Biological;biological adaptation to stress;Biological Assay;Biological Markers;Biology;Breast;Breast biopsy;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;Breast Cancer Risk Factor;Breast Epithelial Cells;Breast Feeding;Cancer Biology;cancer cell;cancer health disparity;cancer subtypes;Cell Communication;Cell Death;cell immortalization;Cell Line;Cessation of life;Characteristics;Chronic;Clinical;Clonal Evolution;Coculture Techniques;cohort;Communities;Data;Data Set;determinants of treatment resistance;Diagnosis;differentiation in vitro;Disease;Disease Resistance;Disparity;DNA Damage;Drug resistance;Embolism;environmental agent;environmental change;epidemiology study;Epigenetic Process;Ethnic Origin;Exhibits;Exposure to;Gene Expression;Genes;genetic signature;Genomic Instability;Growth;hazard;health determinants;health disparity;Health Services Accessibility;high body mass index;Homeostasis;Hormone Receptor;Immunohistochemistry;Implant;in vivo Model;Incidence;Infiltration;Inflammation;Inflammatory;inflammatory breast cancer;intercellular communication;International;Invaded;Lead;Lesion;Life;Link;Macrophage;Malignant Breast Neoplasm;mammary;Mammary gland;Mammary Gland Parenchyma;Maps;Mediating;Medical;Modeling;modifiable risk;Molecular;molecular subtypes;monocyte;mouse model;Multi-Drug Resistance;Multiparity;Mutation;Neoplasm Metastasis;neoplastic cell;Normal Cell;Not Hispanic or Latino;novel;Observational epidemiology;Organoids;Outcome;Pathway interactions;Patients;Pattern;pharmacologic;Phenotype;Pregnancy;Premalignant Cell;prevent;Primary Neoplasm;Proliferating;Public Health;Race;Reproductive History;Research;Resistance;response;Risk Factors;Scientist;Signal Transduction;Skin;Socioeconomic Status;stem cells;Stimulus;Stress;Stress Response Signaling;stressor;Stromal Neoplasm;Symptoms;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;therapy outcome;therapy resistant;Tissues;trait;Treatment Efficacy;tumor;tumor growth;tumor heterogeneity;tumor initiation;tumor microenvironment;tumor progression;Tumor Stem Cells;Tumor-associated macrophages;tumorigenic;United States;Variant;White Women;Woman;Work;Zoledronic Acid

PROJECT_TITLE: Molecular Determinants of Health Disparities in Inflammatory Breast Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-J(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: COLLEGE STATION

ORG_DEPT: CHEMISTRY

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: Project Narrative Targeting of essential viral RNA structures rather than proteins is a potentially transformative antiviral strategy. This project seeks to develop a novel antiviral discovery platform that overcomes many of the challenges associated with selective RNA targeting, leading to increased productivity of RNA-targeted screening campaigns. The proposed technologies will be developed around severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with the goal of identifying RNA-targeted small molecules that inhibit viral replication.

PI_NAMEs: SCZEPANSKI, JONATHAN THOMAS (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Address;Affinity;Anti-viral Agents;Antibodies;antiviral drug development;aptamer;Area;Attention;Base Pairing;betacoronavirus;Binding;Biochemical;Biological Assay;Cells;Charge;Chemicals;combat;Couples;COVID-19 pandemic;Development;DNA;drug discovery;Drug Targeting;Drug usage;Elements;enantiomer;future outbreak;Goals;high throughput screening;Image;Ligands;Methodology;Molecular Conformation;novel;Nucleic Acids;Nucleotides;Oligonucleotides;Optics;Pharmaceutical Preparations;Process;Productivity;Property;Proteins;Publishing;Research Project Grants;Ribose;RNA;RNA Binding;RNA Viruses;RNA-targeting therapy;SARS-CoV-2 antiviral;SARS-CoV-2 genome;screening;small molecule;small molecule inhibitor;small molecule libraries;Specificity;stereochemistry;Structure;Technology;Time;Untranslated RNA;variants of concern;Vertebral column;Viral;Viral Genome;Viral Physiology;Viral Proteins;viral RNA;Virus;Virus Replication

PROJECT_TITLE: An L-Aptamer-Displacement Assay for High-Throughput Screening of RNA-Targeted Small Molecule Antivirals

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Princeton

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: We have created FlyWire, an online community of Drosophila neurobiologists collaborating to proofread an automated reconstruction of a fly brain from electron microscopic images. Here we propose to disseminate FlyWire widely to scientists, both experimentalists and theorists, who will leverage FlyWire for fundamental discoveries about brain development and function.

PI_NAMEs: MURTHY, MALA  (contact)

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TITLE: Dissemination of FlyWire, A Whole-Brain Connectomics Resource


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Unintentional Childhood Injury

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE Bicycling is a leading cause of childhood injury and crashes with motor vehicles cause fatalities and severe injuries with long-term physical and psychological sequelae. This project will use novel technology to observe real-world naturalistic bicycling (safety behaviors and errors) to evaluate the impact of an early adolescent bicycle safety education program and parent training session component. The long-term goal of this project is to reduce the burden of childhood bicycling injuries and increase bicycling safety.

PI_NAMEs: HAMANN, CARA  (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Address;Adolescent;Age;Behavior;Behavior assessment;behavior change;Behavioral;bicycle injury;bicycle safety;Bicycling;Child;Child Development;Childhood;Childhood Injury;Cities;Cluster randomized trial;Code;Communities;comparison control;Competence;consumer product;Control Groups;County;Data;data acquisition;Data Collection;data portal;Development;Economically Deprived Population;Educational Curriculum;Educational Intervention;Educational process of instructing;Effectiveness;effectiveness evaluation;elementary school;Emergency department visit;Evaluation;Evaluation Methodology;Event;Fatal injury;Feedback;Foundations;Goals;group intervention;Hand;hazard;Helmet;Home;Hour;Impact evaluation;improved;improved outcome;Information Systems;Injury;innovation;Intervention;Iowa;Knowledge;Libraries;Location;Measures;Methodology;Methods;Minority;Motor Vehicles;Neighborhoods;new technology;North Carolina;Outcome;Outcome Study;parenting intervention;Parents;Participant;Perception;Performance;Persons;Play;Predisposition;Prevalence;Program Evaluation;programs;psychologic;Randomized;randomized trial;Randomized, Controlled Trials;Recreation;recruit;Research;Risk;Risk Behaviors;Risk Taking;Role;Route;Safety;safety education;Scanning;Schools;Self Efficacy;severe injury;Signal Transduction;Site;skills;summer program;Surveys;System;Technology;Testing;three-arm study;tool;Training;Training and Education;Transportation;Traumatic Brain Injury;Travel;virtual environment;Work;Youth

PROJECT_TITLE: A cluster randomized trial to improve adolescent bicycling safety

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Women's Health Research

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adult;Adverse event;Africa;Age;age group;antiretroviral therapy;barrier to testing;Binding;Birth;Botswana;Cessation of life;Child;Clinical;cohort;cost;Country;Data;Databases;Diagnosis;Diagnostic;diagnostic strategy;Diagnostic tests;Discipline of obstetrics;Dose;effectiveness evaluation;Enrollment;experience;Goals;Guidelines;Health;high risk;high risk infant;HIV;HIV diagnosis;HIV Infections;HIV-1;Hospitalization;Human immunodeficiency virus test;Immunologics;implementation research;improved;in utero;infancy;Infant;infant outcome;Infection;International;Laboratories;Lamivudine;Life;Lopinavir/Ritonavir;Maternal-Fetal Transmission;Measures;Methodology;Modernization;Modification;Mothers;neonate;Nevirapine;New Agents;Newborn Infant;novel therapeutics;Outcome;Perinatal;Pharmaceutical Preparations;point of care;point of care testing;Positioning Attribute;Pregnant Women;program costs;Program Effectiveness;Program Research Project Grants;programs;Recommendation;Regimen;Research;Research Design;Resource-limited setting;RNA;screening;Site;Target Populations;Testing;Time;Treatment Failure;Treatment outcome;treatment program;Treatment Protocols;Viral;viral rebound;Viral reservoir;Visit;Zidovudine

PROJECT_TITLE: Point-of-Care HIV Testing and Early Dolutegravir Use for Infants


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Childhood Injury;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Unintentional Childhood Injury

ORG_CITY: EVANSTON

ORG_NAME: ENDEAVOR HEALTH CLINICAL OPERATIONS

PHR: This goal of the study is to elucidate basic mechanisms of resting state functional MRI regulation and the role of interneurons during postnatal development in rabbits. As a result we expect to develop a specific early MRI marker to detect interneuron injury after perinatal hypoxia-ischemia prognostic of behavioral and cognitive impairments.

PI_NAMEs: DROBYSHEVSKY, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: 3 year old;Adult;Age;Agonist;Animals;antagonist;antenatal;Behavior Disorders;Behavioral;behavioral impairment;Biological Markers;biomarker development;Blood flow;blood oxygen level dependent;Blood Vessels;Brain;Brain Hypoxia-Ischemia;Brain Injuries;Brain region;Cannulas;Cell Count;Cells;Cognition Disorders;Cognitive;Cognitive deficits;Data;Development;Diagnosis;early detection biomarkers;Early Intervention;Electrodes;Electrophysiology (science);Equilibrium;experience;fetal;field study;Frequencies;Functional Magnetic Resonance Imaging;GABA Receptor;gamma-Aminobutyric Acid;Glutamate Receptor;Goals;Growth;hippocampal pyramidal neuron;Human;Hyperactivity;hypoxic ischemic injury;Hypoxic-Ischemic Brain Injury;Impaired cognition;Impairment;Implant;improved;Infant;Injury;insight;interest;Interneurons;Intervention;Lasers;Learning;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Measures;Microinjections;Modality;Modeling;Motor;Neonatal;Neonatal Intensive Care;neonate;Neurodevelopmental Impairment;neuronal circuitry;Neurons;Newborn Infant;Oryctolagus cuniculus;Outcome Study;Oxygen;Pacemakers;patch clamp;Pattern;Perfusion;Perinatal Brain Injury;perinatal development;Perinatal Hypoxia;perinatal period;pharmacologic;Physiological;Play;postnatal development;postnatal period;Premature Infant;prognostic;prognostic assays;prognostic value;prognostication;Property;Regulation;Reporting;Rest;Role;sensor;serial imaging;Shapes;Signal Transduction;Sleep;Somatosensory Cortex;Testing;Time;Tissues;Western Blotting

PROJECT_TITLE: Role of interneurons in resting state fMRI connectivity during normal development and after perinatal brain injury

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Biotechnology;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Current genetic studies largely ignore most of the entire human history that gave rise to genetic variation. This proposal will leverage recent breakthroughs in inferring the sequence of genealogies across the genome to develop novel analytical methods in multiple subdisciplines of human genetic research. The result of our proposal will improve the way genetic studies are designed and analyzed, leading to a better understanding of the genetic risk factors to diseases, particularly in understudied admixed populations.

PI_NAMEs: CHIANG, CHARLESTON  (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Address;Admixture;African American population;African ancestry;Alleles;analytical method;Asian population;Benchmarking;causal variant;Collection;Complex;Data;Data Set;design;Development;Discipline;Disease;Distant;DNA;East Asian;Epidemiologist;ethnic minority population;Etiology;European;Event;Evolution;experience;Genealogical Tree;Genealogy;Genes;Genetic;genetic analysis;genetic architecture;genetic pedigree;Genetic Recombination;Genetic Research;genetic risk factor;Genetic study;Genetic Variation;Genome;genome wide association study;genome-wide;Genomic medicine;Genomic Segment;Genomics;Genotype;Geography;Goals;Graph;Haplotypes;Heritability;Heterogeneity;Hispanic Populations;Historical Demography;Human;human disease;Human Genetics;improved;Indigenous American;Individual;Inherited;innovation;interest;Latino;method development;Methods;Minority Groups;Modeling;Mutation;Native Hawaiian;Natural Selections;novel;novel strategies;open source;Patient Recruitments;Persons;Phenotype;Polynesian;Population;population based;Population Genetics;Population Heterogeneity;Population Sizes;Positioning Attribute;prevent;Process;Recording of previous events;Research;Sampling;simulation;Structure;Testing;Time;trait;Trees;United States

PROJECT_TITLE: A genome-wide genealogical framework for statistical and population genetic analysis

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]