NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Neurosciences

PI_NAMEs: LEIN, PAMELA J (contact)

PROJECT_TERMS: Acute;Administrator;Advanced Development;Analytical Chemistry;authority;Award;Calendar;central database;chemical threat;Chemicals;cholinergic;Cholinesterase Inhibitors;Chronic;Collaborations;Communication;Communities;Data;data sharing;Database Management Systems;education research;Educational workshop;Ensure;Environmental Health;Equipment and supply inventories;Event;Federal Government;Fostering;Funding;General Population;Goals;Government Agencies;Grant;Hazardous Substances;Human Resources;IACUC;Individual;innovation;Intellectual Property;interest;Intoxication;Investigational Drugs;Leadership;Legal patent;Logistics;Manuscripts;medical countermeasure;Medical Research;meetings;member;Mission;Monitor;Neurologic;Online Systems;operation;Organophosphates;Outcome;Pharmaceutical Chemistry;Pilot Projects;Policies;pre-Investigational New Drug meeting;Procedures;programs;Publications;PubMed;Qualifying;Readiness;Reagent;recruit;Regulation;Reporting;Research;research and development;Research Institute;Research Personnel;Research Project Grants;Resource Sharing;Safety;Science;Scientist;Secure;Security;Strategic Planning;success;synergism;System;Technology Transfer;Therapeutic;Therapeutic Agents;therapeutic candidate;therapeutic development;timeline;Training;United States Food and Drug Administration;United States National Institutes of Health;Universities;web site;Work

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: DAVIS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PI_NAMEs: GURKOFF, GENE GABRIEL (contact)

PROJECT_TERMS: Academia;Acute;Address;Animal Disease Models;Area;Basic Science;Biometry;career;chemical threat;Chronic;Clinical Trials;cohort;Communities;Complex;design;Development;disadvantaged background;Diverse Workforce;drug development;drug discovery;Drug Screening;education research;Educational Activities;Educational workshop;Effectiveness;effectiveness evaluation;emergency preparedness;Emergency response;Environment;equity, diversity, and inclusion;Evaluation;experience;Exposure to;Faculty;Feedback;Fostering;Future;Generations;Goals;Government;graduate student;Growth;Human Resources;Image;improved;Industry;Innovative Therapy;Institution;instructor;Interdisciplinary Study;Intoxication;Knowledge;Laboratories;Learning;lectures;medical countermeasure;Medical Students;meetings;member;Mentors;Mission;Nervous System Disorder;Neurologic;Neurology;Neurosciences;neurotoxicology;next generation;Organophosphates;Outcome;outreach;Participant;Patients;Pharmaceutical Chemistry;Pharmacology;Pharmacology and Toxicology;Postdoctoral Fellow;Preclinical Testing;Process;programs;recruit;Research;Research Activity;Research Personnel;Research Project Summaries;Research Training;Resources;responsible research conduct;role model;Scientist;skills;socioeconomic disadvantage;success;Therapeutic;Toxicology;Training;Translational Research;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Work

PROJECT_TITLE: Research Education Core


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetic Testing;Genetics;Kidney Disease;Organ Transplantation;Pediatric;Precision Medicine;Transplantation

ORG_CITY: BIRMINGHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative/Relevance Nearly all kidney transplants fail within 10-15 years, reducing health, quality of life and longevity for people with end-stage kidney disease. Pediatric kidney transplant recipients have distinct characteristics and challenges to long-term transplant survival, but have been excluded from recent studies that validated novel clinical and molecular biomarkers of kidney transplant outcomes in adult kidney recipients. This project will conduct a large translational study of clinical and molecular biomarkers in a retrospective and prospective cohort of pediatric and young adult kidney transplant recipients, helping young transplant recipients realize the benefits of molecular biomarkers that are accruing in adults.

PI_NAMEs: SEIFERT, MICHAEL EDWARD (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Acute;Address;Adolescent;Adult;Age;Allografting;Archives;biobank;Biological Markers;Biopsy;Categories;Characteristics;Child;Childhood;Clinical;clinical biomarkers;clinical phenotype;clinical predictors;cohort;Data;design;Detection;detection method;Diagnosis;Diagnostic;Diagnostic Sensitivity;diagnostic tool;early detection biomarkers;Early Diagnosis;End stage renal failure;Epidemiology;Event;Exclusion;Face;Failure;follow-up;Functional disorder;Future;Gene Expression Profile;Genes;Genetic;Health;Histologic;Histology;Immune;Immune system;improved;Individual;Inflammatory;Injury;Institution;Isoantibodies;Kidney;kidney biopsy;Kidney Transplantation;Life Expectancy;Link;Longevity;Measures;Mediating;medication nonadherence;Methods;Modeling;Molecular;molecular marker;molecular phenotype;nano-string;Nephrology;novel;Outcome;Participant;participant enrollment;Pathology;Pathway interactions;Pediatric cohort;Performance;personalized diagnostics;Persons;Phenotype;post-transplant;predictive tools;prognostic performance;prognostic tool;prognostic value;prospective;Prospective cohort;Quality of life;racial diversity;repository;Residual state;Retrospective cohort;Retrospective cohort study;Role;Specificity;surveillance study;T-Lymphocyte;Technology;Testing;tool;Translating;translational study;Transplant Recipients;Transplant-Related Disorder;Transplantation;Uncertainty;Validation;validation studies;vascular injury;young adult;Youth

PROJECT_TITLE: Clinical and Molecular Biomarkers of Endpoints in Pediatric Renal Transplantation

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Precision Medicine

PI_NAMEs: WULFF, HEIKE  (contact)

PROJECT_TERMS: Acetylcholinesterase;Acute;Analytical Chemistry;antagonist;Anti-Inflammatory Agents;Anticonvulsants;Atropine;Benzodiazepines;Biological Assay;Biological Markers;biomarker identification;blood-brain barrier permeabilization;Brain;calcium-activated potassium channel small-conductance;Calpain;chemical resource;Chronic;Cognitive deficits;Collaborations;Cyclooxygenase Inhibitors;Data;Dedications;design;Detection;detection method;Development;Doctor of Philosophy;Dose;Drug Kinetics;endoplasmic reticulum stress;Ensure;Enzyme-Linked Immunosorbent Assay;Epilepsy;Epoxide hydrolase;Exposure to;Formulation;Goals;Immunoassay;Impaired cognition;improved;inhibitor;Intoxication;Isoflurophate;Lead;lipid mediator;liquid chromatography mass spectrometry;Mass Fragmentography;Mass Spectrum Analysis;Measures;medical countermeasure;metabolomics;Monitor;Muscarinic Acetylcholine Receptor;nanobodies;neuroimaging;neuroinflammation;Neurologic;Neurons;Neuroprotective Agents;novel therapeutic intervention;novel therapeutics;Organophosphates;Oximes;Patients;Penetration;Pharmaceutical Chemistry;pharmacokinetics and pharmacodynamics;Pharmacology;physical property;Plasma;Plasminogen Activator Inhibitor 1;predictive marker;professor;Quality Control;Reagent;reagent testing;Recurrence;Reproducibility;Research;Risk;Scientist;Seizures;Services;Severities;small molecule;stability testing;standard of care;STAT3 gene;Status Epilepticus;Therapeutic;therapeutic candidate;Tissues;Transforming Growth Factor beta Receptors;Work

PROJECT_TITLE: Core A: Analytical and Medicinal Chemistry Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Neurosciences

PI_NAMEs: CHAUDHARI, ABHIJIT J (contact)

PROJECT_TERMS: Acute;Affect;analysis pipeline;anatomic imaging;animal imaging;Brain;Brain imaging;Budgets;cellular imaging;Chronic;Collaborations;Communities;data acquisition;Data Analyses;Dedications;Derivation procedure;design;Development;Disease;Doctor of Philosophy;education research;Emerging Technologies;Ensure;Equipment;experience;experimental study;Fluorescence;fluorescence imaging;Functional disorder;Functional Imaging;Future;Genomics;Goals;Grant;Human;human imaging;IACUC;Image;Image Analysis;image processing;imaging biomarker;Imaging Device;imaging modality;imaging probe;imaging science;imaging Segmentation;imaging study;Imaging technology;improved;in vivo;in vivo imaging;Intoxication;kinetic model;Lead;Machine Learning;Magnetic Resonance Imaging;Manuscripts;Measures;Medical Imaging;Methods;Microscopic;Military Personnel;Mission;Modality;Modernization;Molecular;molecular imaging;Monitor;multi-scale imaging data;multimodality;neuroimaging;neuroimaging marker;Neurologic;neuropathology;neurotoxicology;novel;optical imaging;Organophosphates;Pharmacology;Positron-Emission Tomography;Preparation;professor;Protocols documentation;quantitative imaging;Radiology Specialty;radiotracer;Reproducibility;Research;Research Personnel;Resources;response;Scientist;structural imaging;success;Surrogate Endpoint;targeted imaging;Technology;Therapeutic;Therapeutic Intervention;therapeutically effective;Tissue imaging;tool;toxic organophosphate insecticide exposure;Tracer;Training;Translating;Validation;virtual;X-Ray Computed Tomography

PROJECT_TITLE: Core B: Neuroimaging Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Data Science;Neurosciences

PI_NAMEs: TANCREDI, DANIEL JOSEPH (contact)

PROJECT_TERMS: Acute;Address;Adherence;Analytical Chemistry;Behavioral;cholinergic;Cholinesterase Inhibitors;Chronic;Clinical Research;Code;Collaborations;Complex;Data;Data Analyses;Data Collection;Data Pooling;data sharing;data standards;Data Storage and Retrieval;Database Management Systems;design;Development;Drug Kinetics;Education;education research;Ensure;Evaluation;experience;Experimental Designs;experimental study;Faculty;FAIR principles;graduate student;Human Resources;Image;imaging study;improved;Interdisciplinary Study;Intoxication;meetings;Methodology;Methods;Mission;neuroimaging;Neurologic;neurotoxic;novel;novel therapeutic intervention;Organophosphates;Pharmaceutical Chemistry;Pilot Projects;pre-clinical research;Procedures;programs;Reporting;repository;Reproducibility;Reproduction;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Sample Size;Science;Scientist;senior faculty;Severities;sound;standard of care;Statistical Data Interpretation;Statistical Methods;statistics;Status Epilepticus;systematic review;Targeted Research;Therapeutic;Therapeutic Effect;Training;Training and Education;Validation

PROJECT_TITLE: Core C: Statistics Core


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences

PROJECT_TERMS: Acute;acute care;Address;Adult;Adverse effects;Alzheimer's disease model;anakinra;Animals;antagonist;Anti-Inflammatory Agents;Astrocytes;astrogliosis;Atropine;Attenuated;Behavior;Behavior assessment;Benzodiazepines;Biological Markers;Blood;Blood brain barrier dysfunction;Brain;Brain region;chemical threat;Chemicals;Chronic;Clinical;Cognitive;Cognitive deficits;cognitive function;Collaborations;Convulsants;Coxibs;Cyclic AMP;cyclooxygenase 2;Data;Development;Dose;Electroencephalography;Enzyme Inhibition;Epilepsy;Epileptogenesis;Epoxide hydrolase;Face;FDA approved;Female;Gliosis;Goals;Histology;HMGB1 gene;Homologous Gene;Human;IL8 gene;Impaired cognition;improved;in vivo imaging;Incidence;Individual;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Interleukin-1 beta;Interleukin-1 Receptors;Interleukin-6;Intoxication;Isoflurophate;Laboratories;Lead;Life;Link;lipid mediator;lipidome;Magnetic Resonance Imaging;male;Measures;medical countermeasure;Medical Research;Memory Loss;Microglia;mineralization;Minocycline;Modeling;Monitor;Morbidity - disease rate;Motor;Natural History;Nerve Degeneration;neuroinflammation;Neurologic;Neurologic Deficit;Neurological outcome;neuropathology;neuroprotection;novel therapeutics;Organophosphates;Outcome;Oximes;Parkinson Disease;Pathology;Pathway interactions;Pharmaceutical Preparations;Phenotype;Pilocarpine;Positron-Emission Tomography;Pre-Clinical Model;predictive marker;prevent;Prostaglandins;Rattus;Recurrence;Research Institute;Resolution;response;Rest;Risk;Safety;Seizures;Signal Transduction;Signaling Molecule;small molecule inhibitor;Soman;spatiotemporal;standard of care;STAT3 gene;Status Epilepticus;Stroke;Survivors;Testing;Therapeutic;therapeutic candidate;therapeutic target;Treatment Efficacy

PROJECT_TITLE: Project 1: Reduction of Pro-Inflammatory Signaling


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Cerebrovascular;Epilepsy;Neurodegenerative;Neurosciences

PI_NAMEs: GELLI, ANGIE  (contact)

PROJECT_TERMS: Acute;acute care;Address;Albumins;Alteplase;Animals;Astrocytes;Behavior assessment;Biochemical;Biological Markers;biomarker identification;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood coagulation;blood-brain barrier disruption;blood-brain barrier function;Brain;brain endothelial cell;cadherin 5;Calpain;calpain inhibitor;Cell Death;chemical threat;Chemicals;cholinergic;Chronic;cognitive function;Convulsants;Data;data sharing;Detection;efficacy evaluation;Electroencephalography;Epilepsy;Epileptogenesis;Experimental Designs;Extravasation;Female;Fluorescent Dyes;Fostering;Frequencies;Functional disorder;functional outcomes;Gadolinium;Glial Fibrillary Acidic Protein;Goals;Hemorrhage;Histologic;Human;Image;Impaired cognition;improved;in vivo;in vivo imaging;Individual;inhibitor;Injury;Intoxication;Isoflurophate;Life;Link;Literature;macromolecule;Magnetic Resonance Imaging;male;Maps;Measures;Mediating;Mediator;Microglia;Modeling;Molecular;molecular marker;Motor;Nerve Degeneration;neuroinflammation;Neurologic;Neurologic Deficit;Neurologic Effect;Neurological outcome;neurological pathology;neuroprotection;neurovascular;neurovascular unit;novel therapeutic intervention;novel therapeutics;occludin;Organophosphates;Pathway interactions;Pericytes;Permeability;pharmacologic;Plasminogen Activator Inhibitor 1;Poison;Poisoning;prevent;Property;Publishing;Rattus;receptor;Recurrence;Risk;Role;Safety;Seizures;Signal Transduction;small molecule inhibitor;spatiotemporal;standard of care;Status Epilepticus;Survivors;Testing;Therapeutic;therapeutic candidate;therapeutic target;tool;toxic organophosphate insecticide exposure;transcytosis;Transforming Growth Factor beta;translational potential;Treatment Efficacy;wireless sensor

PROJECT_TITLE: Project 2: Protection of Blood-Brain Barrier Function


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences

PROJECT_TERMS: Acetylcholinesterase;Acute;acute care;Amygdaloid structure;antagonist;Anticonvulsants;Atropine;Attention;awake;Behavior;Behavioral;behavioral outcome;behavioral study;Benzodiazepines;Biological Assay;Biological Markers;brain tissue;calcium-activated potassium channel small-conductance;Cell Death;chemical threat;cholinergic;Chronic;Clinical Data;Clinical Trials;Cognition;Cognition Disorders;Cognitive;cognitive function;cognitive testing;combinatorial;Combined Modality Therapy;comparative efficacy;conditioned fear;Data;Deep Brain Stimulation;Development;Dorsal;effectiveness evaluation;Electrodes;entorhinal cortex;Epilepsy;Evaluation;Event;executive function;Exposure to;falls;FDA approved;Female;Frequencies;Functional disorder;Glutamine;Goals;high risk;Hippocampus;Hour;Human;Impaired cognition;Impairment;Implant;improved;Individual;Injury;insight;Interruption;Intervention;Intoxication;Isoflurophate;Learning;Link;long term memory;Longitudinal Studies;male;mass casualty;Measures;Medial Septal Nucleus;Memory;Modeling;Molecular;Morbidity - disease rate;Motor;Muscarinic Acetylcholine Receptor;Natural History;Nerve Degeneration;neural;neurobehavior;neuroinflammation;Neurologic;Neurologic Deficit;Neurological outcome;neuronal excitability;neuropathology;new therapeutic target;novel;object recognition;Organophosphates;Outcome;Oximes;Patients;Performance;Peripheral;Phenotype;Pralidoxime chloride;pre-clinical;Pre-Clinical Model;predictive marker;Prefrontal Cortex;prevent;Rattus;Recurrence;Riluzole;Risk;Seizures;Severities;sex;Short-Term Memory;Sodium Channel;standard of care;Status Epilepticus;Survivors;System;Telemetry;Testing;Therapeutic;therapeutic candidate;Time;touchscreen;Toxic effect;Visuospatial;voltage

PROJECT_TITLE: Project 3: Normalization of Neuronal Excitability


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: KANSAS CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Electronic cigarette (EC) use continues to proliferate and is expected to surpass combustible cigarette use rates within the next two years. The US Food and Drug Administration (FDA) has regulatory authority to set appropriate tobacco product standards to protect public health and has shown interest in exploring a product standard limiting the allowable level of nicotine in e-liquids. African American smokers take larger puffs and inhale more intensely than whites and this study will examine if they may therefore be differentially impacted by proposed EC nicotine product standards that place a ceiling on the allowable levels of nicotine due to compensatory puffing, increased e-liquid consumption, reduced rates of substitution, and greater exposure to non-nicotine constituents.

PI_NAMEs: LEAVENS, ELEANOR LADD SCHNEIDER (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol;Adult;African American;authority;base;Behavior;Biological Markers;Carbon Monoxide;career;Cigarette;cigarette smoke;cigarette smoking;combustible cigarette;comparative;comparative efficacy;Compensation;Consumption;Crossover Design;Data;Disparity;Electronic cigarette;electronic cigarette use;electronic liquid;Engineering;evidence base;Exhalation;experience;Exposure to;Foundations;Goals;Health;Health Benefit;health inequalities;Human;inflammatory marker;Inhalation;innovation;interest;Knowledge;Laboratories;liquid nicotine;Lung;Measurable;Measures;Medicine;Morbidity - disease rate;mortality;Nicotine;nicotine exposure;Outcome;Participant;Pattern;Phase;Policy Maker;Population;Proliferating;Public Health;Randomized;randomized trial;rapid growth;Regulation;Research;Scientist;Smoke;Smoker;Smoking;smoking-related disease;Sodium Chloride;Standardization;System;Tobacco;tobacco products;toxicant;Toxicant exposure;Training;United States Food and Drug Administration;United States National Academy of Sciences;vaping;Vulnerable Populations;week trial;Weight

PROJECT_TITLE: Impact of e-cigarette nicotine concentration on compensation, cigarette use, and biomarkers of exposure and harm in African American and White smokers


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences

ORG_CITY: Chicago

ORG_DEPT: BIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative Human neurodevelopmental disorders of cognition are tightly associated with genetic mutations in nuclear proteins that regulate gene expression and synaptic proteins that control neuronal connectivity in the brain. The higher-ordered three-dimensional (3D) organization of the genome plays fundamental roles in gene expression, but the functions and mechanisms of genome organization in the developing brain remain poorly understood. Our research on the 3D organization of the neuronal genome will provide critical insights on how genome folding shapes neuronal connections to ensure a functional, healthy brain.

PI_NAMEs: YAMADA, TOMOKO  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: 3-Dimensional;Address;Architecture;autism spectrum disorder;B-Lymphocytes;base;Behavior;Binding;Biological;Biological Process;Brain;cancer cell;Cell Nucleus;cell type;Cerebellum;Chromatin;Chromatin Remodeling Factor;Chromosomes;cofactor;Coffin-Siris Syndrome;Cognition Disorders;Complex;Data;Development;DNA;DNA Sequence Alteration;embryonic stem cell;Enhancers;Ensure;Environment;Enzymes;Epigenetic Process;experience;Gene Expression;gene repression;Genes;Genetic Transcription;Genome;Genomics;Goals;Grant;Homeobox;Human;Impairment;in vivo;insight;LIM Domain;Link;Locales;Mediator;Molecular;Morphogenesis;Mus;Mutation;neural circuit;neural patterning;Neurodevelopmental Disorder;Neuronal Differentiation;Neurons;novel;Nuclear;Nuclear Proteins;olfactory sensory neurons;Pattern;Physical condensation;Physiological;Play;postsynaptic;presynaptic;Proteins;recruit;Reporting;Research;RNA Processing;Role;Sensory;Shapes;Signal Transduction;Stimulus;Structure;Synapses;Testing;transcription factor

PROJECT_TITLE: Mechanisms of Genome Organization in Brain Development and Behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(71)R]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: MINNEAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative This project will address fundamental questions about the causes, molecular mechanisms, and phenotypic consequences of regulatory genetic variation. Regulatory variation arises from inter-individual differences in DNA sequence that alter gene expression and underpin much of the genetic risk for common human diseases. A better understanding about the causes and consequences of regulatory variation will improve our ability to predict genetic disease risk from individual genomes.

PI_NAMEs: ALBERT, FRANK WOLFGANG (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Affect;Autoimmune Diseases;Biological Models;Cardiovascular Diseases;Cells;Complex;Computational Biology;disorder risk;DNA;DNA Sequence;fundamental research;Gene Expression;Genes;Genetic;genetic predictors;Genetic Risk;Genetic Variation;Genome;genome-wide;Health;Human;human disease;improved;Individual;Individual Differences;Knowledge;Laboratories;Messenger RNA;Molecular;Nature;Nervous System Disorder;personalized approach;Phenotype;protein degradation;Proteins;Research;Risk;Saccharomyces cerevisiae;Shapes;trait;Variant;Work;Yeasts

PROJECT_TITLE: Causes and consequences of regulatory genetic variation

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: The proposal studies the mechanisms by which the SARS-like clade 1 SARS2 epidemic and zoonotic precursor strains use novel interaction networks to regulate cross species transmission and pathogenesis in mammals. The proposal develops novel reagents and animal models that support the global effort to control the spread and severity of COVID-19 disease.

PI_NAMEs: BARIC, RALPH S (contact);LI, FANG

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;ACE2;Acute Respiratory Distress Syndrome;airway epithelium;Animal Model;Animals;Anti-viral Agents;Binding;Biochemical;Biological Assay;Cells;Cessation of life;China;Chiroptera;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Coronavirus;Coronavirus spike protein;Country;Coupled;COVID-19;COVID-19 outbreak;COVID-19 pandemic;COVID-19 severity;cross-species transmission;Death Rate;Development;Disasters;Elderly;Electrons;emerging virus;Epithelial Cells;experience;Foundations;Future;Genes;Glycoproteins;Goals;Growth;Human;human disease;human model;human tissue;Immunotherapeutic agent;In Vitro;in vivo;Individual;Infection;insight;Laboratories;Light;Lung;Mammals;Mediating;Microscopic;Middle East Respiratory Syndrome Coronavirus;Molecular;Molecular Conformation;mouse model;Mus;Mutation;novel;novel coronavirus;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Peptide Hydrolases;Performance;permissiveness;Physiological;Play;Positioning Attribute;prevent;programs;Proteins;Reagent;receptor;receptor binding;recombinant virus;Research;Research Personnel;respiratory;Role;SARS coronavirus;SARS-CoV-2 pathogenesis;SARS-CoV-2 spike protein;SARS-CoV-2 transmission;Severe Acute Respiratory Syndrome;Site;Species Specificity;Structure;Techniques;Testing;tissue tropism;Tropism;Vaccines;Variant;Viral;Viral Pathogenesis;Virus Replication;Zoonoses

PROJECT_TITLE: Cell entry, cross-species transmission and pathogenesis of novel coronavirus from

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research;Precision Medicine;Rehabilitation

ORG_CITY: PHILADELPHIA

ORG_NAME: ALBERT EINSTEIN HEALTHCARE NETWORK

ORG_STATE: PA

PHR: Project Narrative After amputation of an arm or leg, up to 90% of subjects experience a “phantom limb”, a phenomenon characterized by persistent feelings in the missing limb. Many subjects with a phantom limb experience intense pain in the missing extremity that is often poorly responsive to medications or other interventions. The proposed work will contrast the efficacy of two virtual reality based treatments for phantom limb pain. The more efficacious treatment will be used in a home-based therapy. The neural basis and pathophysiology of phantom limb pain will be explored with ultra-high field MRI imaging. Finally, we will attempt to derive predictors of response to therapy. The investigations are designed to serve as well-planned stages in the translational pipeline and will thus provide a critical bridge to developing a large-scale randomized control trial using an optimized treatment.

PI_NAMEs: BUXBAUM, LAUREL J (contact);COSLETT, H BRANCH

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Adherence;Aftercare;Agreement;Algorithms;Amputation;Anxiety;arm;Auditory;Behavioral;Biological Markers;Brain;classification trees;Client satisfaction;Clinical;clinical biomarkers;clinical implementation;comorbidity;comparative efficacy;Consent;cost;Data;debilitating pain;design;Development;Dropout;efficacious treatment;Ensure;Equipment;Esthesia;experience;Feedback;Feeling;follow-up;Functional disorder;Functional Magnetic Resonance Imaging;Grant;Graph;head mounted display;Home;Human;Image;imaging biomarker;imaging study;indexing;Individual;intense pain;Intervention;Investigation;Knee;Laboratories;Leg;limb amputation;limb loss;Limb structure;Lower Extremity;Magnetic Resonance Imaging;Measures;Mental Depression;Mental Health;Methods;Modification;Motion;Motor;Movement;multimodality;Nature;neural;Neuroanatomy;neuroimaging marker;Neuronal Plasticity;Pain;Pain in lower limb;Pain management;Pain Measurement;pain reduction;Participant;Persistent pain;Persons;Phantom Limb;Phantom Limb Pain;Pharmaceutical Preparations;Play;predicting response;Prediction of Response to Therapy;Predictive Factor;predictive marker;programs;psychologic;Quality of life;Randomized;Randomized, Controlled Trials;regression trees;Research;Rest;Safety;Sampling;Sensory;sensory feedback;Signal Transduction;Syndrome;System;Tactile;Target Populations;telerehabilitation;Testing;translational pipeline;Treatment Efficacy;treatment optimization;Treatment outcome;Treatment Protocols;treatment response;ultra high resolution;Upper Extremity;virtual;virtual reality;Vision;Visual;visual feedback;Work

PROJECT_TITLE: Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Project Narrative Because clinical, educational, and social outcomes and services depend on accurate knowledge of cognitive and linguistic processes, it is necessary to ensure that the benefits of research are not limited to a subset of the population and that linguistically diverse groups are not under-served and under-represented in science. The proposed project focuses on the consequences of bilingualism for language, cognition, and the brain, with the goal of understanding how knowing another language changes memory, decision making, and conceptual organization. This work examines the plasticity of the human brain as it adapts to accommodate multiple languages and provides a basic-science foundation for future translational research to improve health and human services for linguistically diverse populations.

PI_NAMEs: MARIAN, VIORICA  (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Address;Architecture;auditory processing;base;Basic Science;behavior measurement;bilingualism;Brain;Clinical;Cognition;Cognitive;cognitive change;cognitive function;cognitive process;cognitive system;cognitive task;Communities;Comprehension;Cues;Decision Making;density;Development;Dissociation;Education;Electroencephalography;experience;experimental study;Foundations;Funding;Future;Goals;Grain;Health;health care settings;Human;improved;Individual;innovation;insight;Intervention;Judgment;Knowledge;Koreans;Language;language comprehension;Language Development;language processing;Learning;lexical;life span;Linguistics;Link;Measures;member;Memory;Memory Loss;Methods;Moon;Multilingualism;Names;Neighborhoods;neural;neuromechanism;Neurophysiology - biologic function;older adult;Organizational Change;Orthography;Pathway interactions;phonology;Population;Population Heterogeneity;Population Process;preference;Process;Public Health;Questionnaires;Research;Resources;Science;semantic processing;Semantics;Sensory;Services;Shapes;Social outcome;Social Work;Spanish/English;Speech;Statistical Models;Stimulus;System;Testing;Theoretical Studies;Time;tool;Translational Research;Translations;United States;Visual;visual processing;visual search;visual tracking;Work;Writing

PROJECT_TITLE: Cognitive Architecture of Bilingual Language Processing


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: ATLANTA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The research proposed herein aims to discover a new class of covalent E3 ligase recruiters by chemoproteomic approaches. This research will generate novel degraders with the potential to expand the repertoire of E3 ligases, as well as tissue- and disease-specific molecular degraders.

PI_NAMEs: CHANG, JAEWON  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: adduct;biomaterial compatibility;Chemicals;Chemistry;chemoproteomics;Coupled;Cysteine;design;Development;Disease;Goals;Human Genome;interest;Ligands;Lysine;Modality;Molecular;next generation;novel;novel strategies;novel therapeutics;pharmacologic;protein degradation;Protein Degradation Induction;Proteins;Proteomics;Publishing;recruit;Research;Series;Serine;small molecule;Tacrolimus Binding Protein 1A;Therapeutic;Tissues;Tyrosine;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Chemical Proteomics Approach to Discover Novel Small Molecule E3 Ligase recruiters for Targeted Protein degradation (TPD)

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Chronic Pain;Clinical Research;Health Services;Opioids;Pain Research;Palliative Care;Prescription Drug Misuse;Primary Health Care;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE State policies addressing opioid prescribing may have profound influences on opioid use and pain management among patients with cancer, leading to both intended and unintended consequences. The proposed study will shed light on the extent to which two prominent state policies – mandates for prescriber participation in the Prescription Drug Monitoring Programs and legislative limits on opioids prescribed for acute pain – had intended and unintended effects among three clinically important subpopulations of patients with cancer. Findings will inform continued development of clinical and policy guidelines and interventions at prescriber, provider organization, pharmacy, health plan and policy levels that will support optimal opioid prescribing and pain management for cancer patients.

PI_NAMEs: BAO, YUHUA  (contact)

PROGRAM_OFFICER_NAME: DORIA-ROSE, PAUL P

PROJECT_TERMS: active method;Acute Pain;Address;Adult;advanced disease;Affect;American Society of Clinical Oncology;Analgesics;anti-cancer treatment;Benefits and Risks;cancer care;cancer diagnosis;Cancer Pain Management;Cancer Patient;Cancer Survivor;cancer therapy;care coordination;care providers;Chills;Chronic;chronic pain;chronic pain management;Clinical;clinical development;clinical encounter;Consensus;Coupled;Databases;Disease;Disease remission;dosage;Evaluation;Event;Exclusion;experience;Future;Guidelines;Health;health care service organization;Health Insurance;Health Personnel;health plan;Health Policy;high risk;Hospitals;Indolent;innovation;Insurance;interest;International;Intervention;Life Expectancy;Link;Long Term Survivorship;Long-Term Survivors;Machine Learning;Malignant Neoplasms;Maps;Measures;medical specialties;Medicare;Mining;non-cancer chronic pain;non-opioid analgesic;Oncologist;Oncology;Opioid;opioid epidemic;opioid policy;opioid therapy;opioid use;Outcome;Overdose;Pain;Pain management;patient subsets;Patients;Pattern;Persons;Pharmacy facility;Policies;Policy Maker;Population;Practice Guidelines;prescription monitoring program;prescription opioid;Primary Care;primary care provider;Proliferating;Provider;response;Risk;Specialist;Survivors;therapy development;treatment risk;Treatment-Related Cancer

PROJECT_TITLE: Opioid Treatment of Pain in People with Cancer: Intended and unintended consequences of state policies addressing opioid prescribing

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Microbiome;Precision Medicine

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative Microbiome studies routinely collect multiple -omics data types in order to understand the mechanism by which the microbiome impacts human health and diseases. This project develops novel statistical methods for analysis of microbiome and other -omics data types. The proposed methods will provide systems biology insights into the role of the microbiome in human health and pave the way for intervening the microbiome to address various public health problems.

PI_NAMEs: MA, JING  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Aging;analytical tool;Biological;Biological Markers;Canis familiaris;Collaborations;Communities;Computational algorithm;Computer software;Confidence Intervals;Data;Data Analyses;Data Set;detection platform;Development;dimension reduction;Disease;drug metabolism;Failure;Foundations;Goals;gut microbiome;Health;Health Promotion;high dimensionality;Human;Individual;innovation;insight;Intervention;Joints;Knowledge;Measures;Metabolic Marker;Metabolite Interaction;metabolome;metabolomics;metagenome;Methodology;Methods;Microbe;microbial;microbiome;microbiome analysis;microbiome composition;microbiome research;microbiome therapeutics;microbiota;Modeling;Multiomic Data;multiple omics;Network-based;novel;open source;Outcome;outcome prediction;Pathway Analysis;Pathway interactions;Phylogenetic Analysis;Phylogeny;Play;Precision therapeutics;predictive modeling;Procedures;Production;Public Health;Resources;Role;Sampling;Scientific Advances and Accomplishments;Software Tools;Solid;Statistical Methods;Structure;structured data;Study of Latinos;Systems Biology;Taxon;Taxonomy;Techniques;Testing;therapeutic target;Trees;Uncertainty;user friendly software;Work

PROJECT_TITLE: Statistical Methods for Network-based Integrative Analysis of Microbiome Data

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Hematology;Infectious Diseases;Lung;Rare Diseases;Sepsis

ORG_CITY: AUGUSTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: AUGUSTA UNIVERSITY

PHR: PROJECT NARRATIVE Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS) carry an unacceptably high level of mortality which results from the fundamental lack of effective pharmacological therapies. A common feature of ALI is the loss of endothelial barrier function in the lungs, but a multitude of mechanisms underlie the pathological changes that contribute to pulmonary edema and lung injury. This Project is focused on the novel role of the crosstalk of calpain and myosin light chain phosphatase in endothelial barrier regulation with the goal of accelerating the development of new therapies for ARDS.

PI_NAMEs: SU, YUNCHAO ;VERIN, ALEXANDER D (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acceleration;Actins;Actomyosin;Acute Lung Injury;Acute Respiratory Distress Syndrome;Affect;Antibiotics;Attenuated;Bacteria;Bacterial Infections;Bacterial Toxins;Binding;Calpain;Caspase;Catalytic Domain;Cell Separation;Cyclin-Dependent Kinase 5;Cytoskeletal Modeling;Cytoskeleton;Data;Development;Down-Regulation;Ectopic Expression;Endopeptidases;Endothelial Cells;Endothelium;Escherichia coli;Exposure to;ezrin;Family;Feedback;Focal Adhesions;Gene Delivery;Goals;Head;Human;In Vitro;in vivo;Integrins;Intensive Care;interdisciplinary approach;knock-down;Knock-in Mouse;Knock-out;Knockout Mice;Link;Lipopolysaccharides;Lung;lung injury;lung microvascular endothelial cells;Mammalian Cell;Mediating;Membrane;mimetics;Molecular;mortality;mouse model;Mus;mutant;Mutation;Myosin Light Chains;myosin phosphatase;novel;novel therapeutics;overexpression;Pathologic;Pathway interactions;Patients;Permeability;pharmacologic;Phosphorylation;Plasma;prevent;Protein Dephosphorylation;Protein Family;Proteins;Proteolysis;Pulmonary Edema;Regulation;Resistance;response;rho;Rod;Role;Sepsis;septic;Streptococcus pneumoniae;Streptococcus pneumoniae plY protein;Stress Fibers;Tail;Talin;Testing;tool;Toxin;Ubiquitination;Vinculin;Withdrawal

PROJECT_TITLE: Calpain/talin/MLCP axis in pulmonary endothelial barrier regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-H(03)]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative This proposal for the competing continuation of the University of Pittsburgh Training Program in the epidemiology of aging, funded by the NIA since 1989, is focused on the “Epidemiology of Musculoskeletal Decline and Disability in Aging.” The training program will include 3 pre- doctoral and 2 post-doctoral positions in epidemiology. Our rich multidisciplinary training environment is customized to the background of each trainee to address novel approaches in aging research with an emphasis on cutting-edge biological and physiological methods for epidemiology, a core discipline for research and practice in public health, for the goal of improving the musculoskeletal health and physical function of our aging population.

PI_NAMEs: STROTMEYER, ELSA S. (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Aging;Epidemiology;Training

PROJECT_TITLE: Training in the Epidemiology of Aging


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative Richter’s syndrome (RS) is an aggressive malignancy of B cells that arises in a subset of patients with the otherwise typically indolent chronic lymphocytic leukemia (CLL), and dramatically limits survival in CLL patients. Despite advances in tumor sequencing techniques and analytic tools, the genetic basis of RS remains largely uncharacterized. The objective of the proposed studies is to identify and trace the origins of RS arising from CLL and define its molecular features in order to gain a deeper understanding of the subtypes of RS—which is anticipated to improve both the diagnosis and therapy of RS.

PI_NAMEs: PARRY, ERIN M (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Accounting;Admixture;Advisory Committees;analytical tool;Automobile Driving;B lymphoid malignancy;B-Lymphocytes;Biological;Biological Process;Biology;Cancer Biology;cancer genetics;career;career development;Case Series;Cell Line;Cells;Chronic Lymphocytic Leukemia;Clinical;Clinical Data;cohort;Communities;Computational Biology;Dana-Farber Cancer Institute;Data;design;Detection;detection sensitivity;Development;Development Plans;Diagnosis;disorder control;DNA;DNMT3a;Environment;Epigenetic Process;epigenetic regulation;Event;Evolution;exome sequencing;EZH2 gene;Foundations;functional genomics;Gene Expression;Genes;Genetic;Genetic Transcription;Genetic Transformation;genome sequencing;Genomics;Germ Lines;Goals;Histology;improved;improved outcome;Indolent;insight;International;Knowledge;Laboratories;large cell Diffuse non-Hodgkin's lymphoma;leukemic transformation;Lymphoma;Malignant Neoplasms;Mentors;Mentorship;Modernization;Molecular;Molecular Genetics;Mutation;next generation;novel;Outcome;Pathway interactions;patient subsets;Patient-Focused Outcomes;Patients;Physicians;Process;prognostic significance;prognostication;Recurrence;Research;Research Personnel;Resources;Richter's Syndrome;sample collection;Sampling;Scientist;Signal Transduction;Specimen;statistics;Structure;Techniques;Testing;Therapeutic;therapy resistant;Tissues;Training;transcriptome;transcriptomics;translational scientist;tumor;Variant;whole genome;Work

PROJECT_TITLE: Tracing the Evolution of Chronic Lymphocytic Leukemia to Richter's Syndrome: Defining Transformation

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Overall Project Narrative Rheumatic diseases cause significant morbidity and early mortality, especially in young women and underserved populations, partly because molecular heterogeneity makes diagnosis and treatment selection difficult and often a case of trial and error. The Oklahoma Rheumatic Disease Resources Cores Center helps address these complex disorders by providing centralized access to large collections of well-characterized, diverse patient samples, clinical research infrastructure for new recruitment, investigator and clinical trialist mentoring, expert consulting, and cutting-edge resources. Our Center has long-standing success launching the independent careers of 33 Junior Center Investigators and fostering a host of collaborations, and we commit to expanding these skills and resources to improve the understanding of rheumatic disease mechanisms and patient outcomes.

PI_NAMEs: JAMES, JUDITH A (contact)

PROGRAM_OFFICER_NAME: GARCIA-CAZARIN, MARY

PROJECT_TERMS: Address;Aliquot;American;Applications Grants;assay development;base;Basic Science;biobank;Biological Markers;career;career development;Caring;Cells;Certification;Clinical;Clinical Data;Clinical Management;clinical phenotype;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;Cohort Studies;Collaborations;Collection;college;Communication;Complex;Cytometry;Data;data warehouse;Development;Diagnosis;Disease;disease classification;Distant;Educational workshop;Electronics;empowerment;Enrollment;Evaluation;experience;forging;Fostering;Funding;Genetic;Goals;Health;Heterogeneity;high dimensionality;Human;Human Resources;Immunologic Monitoring;Immunologics;improved;Individual;Information Systems;Infrastructure;innovation;Institution;Institutional Review Boards;inter-institutional;Investigation;investigator-initiated trial;Investments;Leadership;Lupus;Manuscripts;Mediator;Mentors;Mission;Molecular;molecular phenotype;Monitor;Morbidity - disease rate;mortality;multidimensional data;multidisciplinary;multiple omics;National Institute of Allergy and Infectious Disease;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;next generation;novel;Oklahoma;outreach;Participant;Pathogenesis;Pathologic;Pathologist;Patient Selection;patient subsets;Patient-Focused Outcomes;Patients;Phenotype;phenotypic data;Pilot Projects;precision medicine;Precision therapeutics;Preparation;Prevention;Procedures;Process;Prognosis;Program Development;programs;Proteomics;Protocols documentation;recruit;Research;Research Design;Research Infrastructure;Research Personnel;Resources;Rheumatism;sample collection;Sampling;Scholars Program;Science;Scientist;Seasons;Selection for Treatments;Services;skills;success;Symptoms;systems research;Technology;technology platform;Testing;Training;Training Programs;transcriptomics;Underrepresented Populations;Underserved Population;Visit;web-enabled;Work;Writing;young woman

PROJECT_TITLE: Oklahoma Rheumatic Disease Research Cores Center


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

PROJECT_TERMS: Acceleration;Adult;Advisory Committees;Advocate;Aliquot;Autoantibodies;Autoimmune;Autoimmunity;Award;biobank;Blood Vessels;Cardiology;career;career development;Certification;Childhood;Clinical;clinical care;Clinical Data;Clinical Investigator;clinical phenotype;Clinical Research;Clinical Trials;Coagulation Process;Code;Collaborations;Collection;Communication;Communities;Connective Tissue Diseases;Data;Databases;Degenerative polyarthritis;Dermatology;Development;Discipline;Disease;Distant;Educational workshop;effectiveness evaluation;Endocrinology;Ensure;Epidemiologist;Epidemiology;Etiology;Evaluation;Exposure to;forging;Fostering;Funding;Future;Gene Expression Profiling;Genetic;Genotype;Geriatrics;Goals;Grant;Hematology;House Staffs;Human;Human Resources;Hypersensitivity;Immune;Immunologist;Immunology;improved;Individual;Inflammation;Institution;interdisciplinary approach;interest;Investigation;Investments;Leadership;Lupus;Manuscripts;Mediator;Medicine;meetings;member;Mentors;Mission;Molecular;molecular pathology;multidisciplinary;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;Oklahoma;Oncology;outreach;Participant;Pathogenesis;patient subsets;Patients;Phenotype;Precision therapeutics;preclinical study;Prevention;Program Development;programs;Publications;PubMed;Qualitative Evaluations;Quantitative Evaluations;Research;Research Personnel;Research Project Grants;Resources;Rheumatism;Rheumatology;Sampling;Scholars Program;Science;Series;Services;Sjogren's Syndrome;Structure;Students;success;Suggestion;symposium;Systemic Lupus Erythematosus;Technology;Testing;Therapeutic Trials;tribal community;undergraduate student;Underrepresented Populations;Undifferentiated;United States National Institutes of Health;user-friendly;web-enabled;Writing

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: EY

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Eye Disease and Disorders of Vision;Nanotechnology;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Neuromodulation through brain-machine interfaces such as neural implants is essential to study the functions of our brain and to develop treatments for neurological disorders. Our goal is to develop a novel minimally-invasive and optoelectronic interface to wirelessly modulate the activity of neurons with subcellular resolution, overcoming the major limitations of current implantable technologies. This interface will be constructed as an ultra-small and thin polymeric film that will conform to the neuronal membrane and establish an exceptional symbiosis with the cell, pioneering a novel concept of brain-machine interface for advances in treatment of brain diseases and elucidating neurological questions like learning and plasticity.

PI_NAMEs: SARKAR, DEBLINA  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TITLE: A Novel Wireless and Subcellular Device for Neuromodulation


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: NATIONAL BUREAU OF ECONOMIC RESEARCH

PHR: OTHER PROJECT INFORMATION – Project Narrative This project will produce an annual database of mortality rates covering the U.S. population incorporating income, race and ethnicity, and use this database to understand determinants of mortality and health inequality in the COVID-19 pandemic and beyond.

PI_NAMEs: CHETTY, RAJ  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: 2019-nCoV;Address;Affect;Age;American;Area;Behavior;beneficiary;Black American;Censuses;Cessation of life;Characteristics;Code;Collaborations;Communities;Community Surveys;Consultations;County;COVID-19;COVID-19 impact;COVID-19 mortality;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Set;Databases;Death Rate;Death Records;Deaths of despair;demographics;Development;Dimensions;Dislocations;Disparity;Disparity population;disparity reduction;Economically Deprived Population;Economics;Employment;Ethnic Origin;Excess Mortality;experience;Gender;Geographic Locations;Geography;Health;Health behavior;health disparity;health inequalities;Health Services Accessibility;Hispanic Americans;Household;human old age (65+);Income;income disparities;Individual;Inequality;infection rate;Intervention;Life Expectancy;Link;long term COVID-19 pandemic impacts;Long-Term Effects;Longevity;Low income;Measurement;Measures;men;Monitor;mortality;Mortality Determinants;mortality disparity;mortality statistics;Outcome;outcome disparities;pandemic disease;Paper;Policies;Population;post-pandemic;programs;public database;Publishing;Race;racial disparity;Recurrence;Regression Analysis;Research;Research Personnel;research study;Resources;safety net;Sampling;social;Social Security;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Status;socioeconomics;Source;statistics;Subgroup;success;Surveys;Taxes;Time;tool;trend;underserved community;Underserved Population;United States;United States National Institutes of Health;Update;Variant;Vulnerable Populations;Woman;Work

PROJECT_TITLE: A New Database to Measure the Association Between Income, Race, and Mortality: Inequality in Longevity During and Beyond the COVID-19 Pandemic


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Precision Medicine

PI_NAMEs: MERRILL, JOAN T. (contact)

PROJECT_TERMS: Aliquot;American;Autoantibodies;Autoimmune;Autoimmune Diseases;base;biobank;career;Caring;Certification;Classification;Clinic;Clinical;Clinical Data;clinical phenotype;Clinical Protocols;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;Collaborations;Collection;college;Complex;COVID-19;COVID-19 impact;Data;data complexity;Data Reporting;data warehouse;Disease;Distant;Dose;Flare;Funding;Genetic;Geographic Locations;Goals;Grant;Home;Human;Human Resources;human subject;Human Subject Research;Immunologics;improved;individualized medicine;Informatics;Information Systems;Infrastructure;innovation;insight;Institutional Review Boards;Intervention Studies;investigator-initiated trial;Investments;Link;Mentors;Mentorship;Methods;Modeling;Molecular;molecular phenotype;Monitor;novel;novel strategies;Oklahoma;Outcome;Participant;Pathologist;Pathology;patient oriented;Patient Outcomes Assessments;Patient Participation;Patient Recruitments;patient subsets;Patients;Pharmacologic Substance;Phenotype;phenotypic data;Population;post-COVID-19;precision medicine;Process;prospective;protocol development;Protocols documentation;Publications;PubMed;recruit;repository;Reproducibility;Research;research clinical testing;Research Design;Research Personnel;Research Support;Resources;Rheumatism;Rheumatology;sample collection;Sampling;Science;Scientist;Secure;Selection for Treatments;Services;Site;Sjogren's Syndrome;Stratification;Subjects Selections;System;Systemic Lupus Erythematosus;Testing;Time;Training;Translational Research;trial design;underserved area;United States National Institutes of Health;vaccine trial;Visit

PROJECT_TITLE: Clinical Characterization and Biorepository Core


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biotechnology;Genetics;Human Genome;Precision Medicine

PI_NAMEs: GUTHRIDGE, JOEL MARVIN (contact)

PROJECT_TERMS: Address;antibody detection;Area;Autoimmune Diseases;Awareness;B-cell receptor repertoire sequencing;base;biobank;Biological Markers;Blood;Blood Cells;cell fixing;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chromium;Clinical;clinical center;Competence;Complex;Consultations;Cytometry;Data;Data Analytics;Data Set;Development;Diagnostic;Dimensions;Disease;Dissociation;Education;Emerging Technologies;Epigenetic Process;Equipment;experience;Experimental Designs;Freezing;Funding;Future;Generations;Genetic;Genetic Polymorphism;Genomic DNA;Genomics;Genotype;Heterogeneity;Histology;Human;human disease;Human Herpesvirus 4;Human Resources;Image;Immunofluorescence Immunologic;Immunologics;Immunophenotyping;Individual;Institution;Mediator;Methods;Modeling;Molecular;Molecular Disease;molecular phenotype;Molecular Profiling;Multiomic Data;multiple omics;nano-string;new technology;Oklahoma;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patient Care;patient stratification;Patients;Phenotype;phenotypic data;Plasma;Population;precision medicine;Process;prognostic tool;programs;protein biomarkers;Proteomics;Quality Control;Research;Research Personnel;Resolution;Resources;Rheumatism;RNA;Sampling;Secure;Serum;Services;single nucleus RNA-sequencing;single-cell RNA sequencing;success;T-cell receptor repertoire;Technology;Therapeutic;Time;Tissue Banks;tissue fixing;Tissues;Training;Transcript;transcriptome;transcriptomics;Transformed Cell Line;Translating;treatment response;Update;whole slide imaging

PROJECT_TITLE: Human Phenotyping Core


NIH_SPENDING_CATS: Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research;Rehabilitation

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The aim of this research is to reveal the fundamental neural mechanisms that underlie comprehension across human spoken languages. An understanding of how speech is coded in the brain has significant implications for the development of new diagnostic and rehabilitative strategies for language disorders (e.g. aphasia, dyslexia, autism, et alia). A cross-linguistic approach is critical for a true understanding of language, and this proposal strives to achieve a broader view of diversity and inclusion in neuroscience.

PI_NAMEs: CHANG, EDWARD  (contact)

PROGRAM_OFFICER_NAME: GEBREHIWET, HERMON RUSSOM

PROJECT_TERMS: Acoustics;Acute;Address;Aphasia;Auditory;Auditory area;auditory processing;autism spectrum disorder;awake;Behavior;bilingualism;Brain;Brain Mapping;Brain Neoplasms;Central Hearing Loss;Chinese;Chronic;Clinical;Code;Communication impairment;Comparative Study;Complex;Comprehension;Cues;density;Development;Disease;diversity and inclusion;Dyslexia;Electrodes;Elements;Epilepsy;Equipment and supply inventories;Event;experience;Goals;Human;Individual;innovation;insight;Investigation;Knowledge;Language;Language Development Disorders;Language Disorders;Lateral;lexical;Linguistics;Methodology;Modeling;Nervous System Disorder;neural;neuroimaging;neuromechanism;neurophysiology;Neurosciences;Neurosurgical Procedures;Noise;non-Native;novel;novel diagnostics;Participant;Patients;Pattern;Phonetics;phonology;Population;Process;programs;Property;Rehabilitation therapy;remediation;Research;Resolution;response;signal processing;Signal Transduction;Site;sound;Spanish;Spanish/English;spatiotemporal;Specific qualifier value;Speech;speech processing;Speech Sound;speech synthesis;statistics;Stimulus;Stress;Surface;Temporal Lobe;temporal measurement;Testing;theories;Work

PROJECT_TITLE: The neural coding of speech across human languages


ORG_DEPT: PATHOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative: In addition to the dominant structures like the cortical actin cytoskeleton and the stress fibers, actin filaments in a mammalian cell are also comprised of several lower-abundance and transient pools of dynamic actin filaments that are associated with various organelles. While the role of the dominant structures has been explored, questions remain regarding the spatio-temporal regulation of these discrete and dynamic pools of actin and the specific role they play in shaping organelle and cellular homeostasis. Using cellular and biochemical tools, this research program will characterize the organelle-associated pool of actin filaments with respect to its assembly factors, associated proteins and signaling mechanism and aim to elucidate its role in organelle biology both in human physiology and pathology.

PI_NAMEs: CHAKRABARTI, RAJARSHI  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TITLE: Elucidating the roles for discrete actin filaments in maintenance of organelle and cellular homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


ADMINISTERING_IC: MH

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: Princeton

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative Understanding the origin of individual differences in behavior is not only a question of deep fundamental interest, but is also central to understanding the variable penetrance of neuropsychiatric disease. We propose and intend to test a new hypothesis regarding the origin of individual differences: that they arise in part from small differences in initial conditions caused to be amplified by positive feedback, such that different individuals from different reward associations within the same environment. This results from the fact that the world is high-dimensional, in that there are almost always multiple possible actions or events that could be attributed to reward.

PI_NAMEs: WITTEN, ILANA  (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TITLE: Individual differences through self-reinforcement of suboptimal strategies


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention;Rehabilitation;Sleep Research

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE  Older adults who survive hospitalization in the intensive care unit (ICU) may experience distressing symptoms, such as cognitive impairment, which may prevent them from remaining independent after discharge. Disturbances in sleep and circadian rhythm are prevalent among ICU patients and may contribute to delirium, which could result in subsequent cognitive decline. The proposed study will determine preliminary individual and combined effects of behavioral interventions that target sleep, circadian rhythm, and cognitive function, and will guide future clinical trials to help older ICU survivors manage these symptoms throughout their recovery.

PI_NAMEs: ELIAS, MAYA  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: actigraphy;active control;Adult;Affect;Age;Alzheimer's disease related dementia;Behavior Therapy;Behavioral;Biological;Body Temperature;Chronotherapy;circadian;Circadian Rhythms;Clinical;Clinical Trials;Clinical Trials Design;Cognition;Cognitive;cognitive function;cognitive training;Cohort Studies;computerized;COVID-19;Critical Care;Critical Illness;Data;Delirium;design;Development;Distress;Dose;Earplug;Educational Intervention;Elderly;Enrollment;Ensure;Equation;executive function;experience;Eye;Foundations;Funding;Future;Goals;Grant;Heart failure;high risk;Hip Fractures;Hospitalization;Hospitals;Impaired cognition;improved;improved outcome;Individual;Intensive Care;Intensive Care Units;Intervention;intervention effect;Intervention Trial;K-Series Research Career Programs;Knowledge;Malignant Neoplasms;Masks;Mediating;Mentored Patient-Oriented Research Career Development Award;Methodology;Modeling;multimodality;Obstructive Sleep Apnea;older adult;Outcome;Outcome Study;Participant;Patients;Pharmaceutical Preparations;Polysomnography;post-doctoral training;Postdoctoral Fellow;prevent;Principal Investigator;programs;psychological outcomes;Randomized;Randomized, Controlled Trials;Recording of previous events;Recovery;Research;risk mitigation;Risk Reduction;Sample Size;Science;Series;Severities;Severity of illness;sex;Sleep;Sleep Deprivation;Sleep disturbances;Spanish;Statistical Data Interpretation;Sum;Survivors;symptom management;symptom science;symptomatic improvement;Symptoms;Syndrome;Testing;Training;Training Activity;Treatment Efficacy;United States National Institutes of Health;wearable sensor technology

PROJECT_TITLE: A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Immunotherapy;Lung;Lung Cancer;Radiation Oncology

ORG_CITY: Columbus

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Some lung cancer patients respond well to therapy while others do not. We are investigating the repurposing of an FDA-approved drug to enhance the effectiveness of established radiation and immunotherapy for lung cancer.

PI_NAMEs: DENKO, NICHOLAS C. (contact);LI, ZIHAI ;WILLIAMS, TERENCE MARQUES

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Address;anti-PD-1;anti-PD1 therapy;Antigens;Antioxidants;Blood;Blood Pressure;Blood Vessels;Cancer Model;Cancer Patient;cancer therapy;Cell Line;Cell Respiration;Cell Transplantation;Cells;chemoradiation;Chemoresistance;chemotherapy;Chemotherapy and/or radiation;Chronic;Clinical;Clinical Research;Clinical Treatment;Clinical Trials;Complex;Data;Data Set;Databases;Dependence;design;DNA sequencing;Dose;driver mutation;Drops;Effectiveness;Electron Transport;Engineering;Enrollment;Equilibrium;Erectile dysfunction;exhaust;exhaustion;FDA approved;Future;Gastrointestinal tract structure;Gene Expression;Genes;Genetic;Genetic Transcription;Human;Hypoxia;Image;imaging study;Immune;immune cell infiltrate;immune checkpoint blockade;Immunocompetent;Immunophenotyping;Immunotherapeutic agent;Immunotherapy;improved;in vitro testing;inhibitor;innovation;Intervention;Intravenous infusion procedures;Lead;Lung;Magnetic Resonance Imaging;Malignant neoplasm of lung;Malignant Neoplasms;Maximum Tolerated Dose;Metabolic;Metabolism;migration;Mitochondria;mitochondrial metabolism;Modality;Modeling;mRNA sequencing;Mus;Muscle relaxants;mutant;Mutation;Neoplasm Transplantation;neoplastic cell;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;novel;novel strategies;Oncogenic;Outcome;Oxidative Phosphorylation;Oxygen;Oxygen Consumption;Papaverine;Parents;Pathway interactions;Patient-Focused Outcomes;Patients;PD-1 blockade;Perfusion;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacologic;Phase I Clinical Trials;phase I trial;Phenotype;phosphoric diester hydrolase;Physiology;Population;Pre-Clinical Model;Process;progenitor;prognostic indicator;programs;Radiation;radiation resistance;radiation response;Radiation therapy;Radio;Radioimmunotherapy;Radiosensitization;Refractory;Reporter;Research Personnel;Resistance;response;Safety;Side;Smooth Muscle;standard of care;System;T cell infiltration;T-Cell Activation;T-Lymphocyte;Testing;The Cancer Genome Atlas;Theft;theories;Therapeutic;treatment response;tumor;tumor DNA;tumor hypoxia;tumor microenvironment;Tumor Oxygenation;Up-Regulation;vascular bed;Vascular resistance;Vasospasm

PROJECT_TITLE: Overcoming Hypoxic Resistance in Non-Small Cell Lung Cancer By Targeting Mitochondrial Metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-L(02)M]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Emerging Infectious Diseases;HIV/AIDS;Health Services;Infectious Diseases;Lung;Lung Cancer;Prevention;Rare Diseases;Substance Misuse;Tobacco;Tobacco Smoke and Health;Tuberculosis

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE (Public Health Relevance) People with HIV who smoke have little access to resources to help them quit, and smoking cessation interventions are needed that can be scaled within existing HIV care infrastructure. We will evaluate how smoking cessation strategies known to work in other populations may support people with HIV in South Africa quit smoking utilizing the existing infrastructure of routine HIV care. We will assess the ability of these smoking cessation interventions to help PWH quit, as well as how feasible, acceptable, and cost-effective they are in this setting to inform ways to bring the program to scale.

PI_NAMEs: GOLUB, JONATHAN E. (contact);MARTINSON, NEIL A

PROGRAM_OFFICER_NAME: CORREA-MENDEZ, MARGARITA

PROJECT_TERMS: Abstinence;Address;Adoption;Adult;Age;antiretroviral therapy;arm;Behavioral;Biochemical;budget impact;Carbon Monoxide;Cardiovascular Diseases;Caring;Cause of Death;Chronic Obstructive Pulmonary Disease;Cigarette;Clinic;Clinical;Clinical Practice Guideline;Clinical Trials;comorbidity;cost;cost comparison;cost effective;cost effectiveness;Cost effectiveness research;Cotinine;Counseling;craving;Data;design;Development;effective intervention;Effectiveness;effectiveness/implementation study;efficacy evaluation;Enrollment;Epidemiologist;epidemiology study;EuroQOL;evidence base;Evidence based intervention;Exhalation;Gender;Goals;Guidelines;health related quality of life;high risk;HIV;Home;implementation cost;implementation determinants;implementation evaluation;implementation fidelity;implementation/effectiveness;Incidence;Infrastructure;Intervention;intervention effect;Lung;Maintenance;Malignant Neoplasms;Measures;Mediator;men;Motivation;nicotine craving;nicotine gum;nicotine patch;nicotine replacement;Outcome;Participant;patient screening;Patient Self-Report;Patients;peer;peer support;peri-urban;Persons;PF4 Gene;Phase;Policies;Population;Prevalence;primary care setting;primary outcome;programs;Psychologist;public health relevance;Randomized;Randomized, Controlled Trials;Research;Resource-limited setting;Resources;Risk Factors;scale up;Scientist;screening;secondary outcome;Self Efficacy;service delivery;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;smoking initiation;smoking prevalence;smoking-related disease;social;South Africa;South African;Stress;stressor;success;Target Populations;therapy development;Time;tobacco screening;Tobacco smoking behavior;Tobacco Use Cessation;treatment optimization;treatment strategy;Tuberculosis;urban setting;Urine;varenicline;Variant;Woman;Work

PROJECT_TITLE: Evaluating smoking cessation interventions for PWH in South Africa: Efficacy, implementation, and cost-effectiveness.


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Substance Misuse

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PUBLIC HEALTH RELEVANCE STATEMENT: Heavy alcohol drinking has been shown to be linked to the onset and severity of Alzheimer’s disease. In patients with Alzheimer’s disease, cognitive decline is related to the development of abnormal forms of the protein tau. In this project, we will elucidate how extracellular cold inducible RNA-binding protein (eCIRP) mediates tau abnormalities caused by alcohol, and investigate whether they can be attenuated by targeting eCIRP with a small peptide. This project will help us not only understand the molecular mechanism involved in the relationship between alcohol and Alzheimer’s disease, but also provide new potential therapeutic strategies to treat patients with Alzheimer’s disease in the future.

PI_NAMEs: MARAMBAUD, PHILIPPE ;WANG, PING  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Affinity;Alcohol consumption;alcohol effect;alcohol exposure;alcohol measurement;Alcohols;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Animal Model;Animals;Attenuated;Binding;Binding Proteins;binge drinking;blood-brain barrier crossing;Brain;Calcium;Calpain;calpain inhibitor;Cause of Death;Cell membrane;Cerebrospinal Fluid;Cytoplasm;Development;Dose;experimental study;Exposure to;extracellular;Fluorescence Resonance Energy Transfer;Focused Ultrasound;Future;Gene Expression;Goals;hyperphosphorylated tau;IL6ST gene;Impaired cognition;in vivo;inhibitor;Injections;insight;Interleukin 6 Receptor;Interleukin Activation;interleukin-6 receptor alpha;Intravenous;JAK1 gene;JAK2 gene;Knockout Mice;Link;MAPT gene;Mediating;Mediator;Memory impairment;Microglia;Modeling;Molecular;Mus;Nerve Degeneration;neurodegenerative dementia;Neurofibrillary Tangles;Neurons;neutralizing antibody;novel;Pathogenesis;Pathologic;Pathology;Pathway interactions;Pattern;Peptides;Phosphorylation;Phosphotransferases;Preventive;Probability;protein expression;public health relevance;RNA-Binding Proteins;Role;Severities;Signal Transduction;Source;STAT3 gene;Surface Plasmon Resonance;tau aggregation;tau mutation;tau Proteins;tau-1;Tauopathies;Therapeutic;Therapeutic Effect;Time;Transgenic Organisms;TYK2;Up-Regulation;Wild Type Mouse

PROJECT_TITLE: Promotion of Alzheimers Disease by Alcohol - Role of eCIRP


NIH_SPENDING_CATS: Biotechnology;Duchenne/ Becker Muscular Dystrophy;Immunotherapy;Muscular Dystrophy;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: IRVINE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE The current study promises to transform the field by defining how regulatory T cells (Treg) suppress a novel macrophage and stromal cell interaction that promotes muscle fibrosis during Duchenne muscular dystrophy (DMD). Our research has great potential to reveal new targets and innovative therapeutic strategies that inhibit fibrogenic inflammatory responses in DMD.

PI_NAMEs: VILLALTA, SERGIO ARMANDO (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Ablation;Acute;Address;Antibodies;Antibody Therapy;Biological Assay;Cell Communication;Cells;Chronic;Clinical;Complex;Data;Deposition;Development;Disease;Disease Progression;Duchenne muscular dystrophy;Extracellular Matrix;Fibrosis;Foundations;Galectin 3;Gene Expression Profile;Genes;Goals;Histologic;Immune;immune cell infiltrate;Immune system;Immunogenetics;immunoregulation;Immunosuppression;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;innovative technologies;insight;Interferon Type II;Interleukin-10;Interleukin-2;Investigational Therapies;Lymphoid;Macrophage;mdx mouse;Mediating;Mediator;Molecular;Mus;Muscle;muscle degeneration;muscle regeneration;Muscular Dystrophies;Myelogenous;Natural regeneration;novel;novel strategies;osteopontin;Outcome;Outcome Study;Pathogenesis;Pathologic Processes;Pathway interactions;pharmacologic;Population;Process;Production;Regulatory T-Lymphocyte;Reporting;Research;response;Role;Severities;Severity of illness;Signal Transduction;single-cell RNA sequencing;stem;Stromal Cells;System;Testing;Therapeutic;Time

PROJECT_TITLE: Novel macrophage and regulatory T cell interactions that promote the pathogenesis of Duchenne muscular dystrophy

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative Congenital dyserythropoietic anemias (CDAs) are a group of blood disorders in which erythropoiesis, the production of red blood cells, is impaired. Inherited and de novo mutations in the gene VPS4A have recently been identified to be a cause of CDA suggesting a specific requirement for VPS4A function in erythropoiesis. This proposal aims to identify the mechanisms by which VPS4A mutations cause this disease and will reveal a new pathway essential for erythropoiesis enhancing our understanding of both CDA pathogenesis and normal red cell development.

PI_NAMEs: SEU, KATIE GIGER (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: ATP phosphohydrolase;ATPase Domain;Biogenesis;Blood typing procedure;Bone Marrow;career;Cell Culture Techniques;Cell Survival;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Congenital dyserythropoietic anemia;Critical Pathways;Cytokinesis;Cytoplasm;de novo mutation;Defect;Development;Disease;disease natural history;Dominant-Negative Mutation;Endosomes;Erythroblasts;Erythrocytes;Erythroid;Erythropoiesis;Excision;exosome;Failure;Functional disorder;Genes;Genetic Diseases;Goals;Hematological Disease;Heme;Hemolysis;Hemolytic Anemia;Homologous Gene;Human;human disease;human induced pluripotent stem cells;Impairment;In Vitro;in vivo;Individual;induced pluripotent stem cell;Inherited;insight;Integral Membrane Protein;Investigation;Iron;Iron Overload;knock-down;loss of function;Lysosomes;Mammalian Cell;Membrane;Mitochondria;Modeling;Molecular;mouse model;Multivesicular Body;Mus;mutant;Mutation;Neurodevelopmental Disorder;novel;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peripheral;peripheral blood;Phenocopy;Phenotype;Play;Production;receptor;receptor recycling;recruit;Recycling;Reporting;Reticulocytes;Role;Site;Sorting;Spleen;Syndrome;TFRC gene;Time;trafficking;Transferrin;Transfusion;Transgenic Mice;uptake;Vacuolar Protein Sorting;Variant;Vesicle;Viral;Work;Yeasts

PROJECT_TITLE: Role of VPS4A and ESCRT-III in terminal erythropoiesis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK(M1)-1-D]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biodefense and Related Countermeasures;Biomedical Imaging;Cardiovascular;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Lung

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE These studies are relevant to public health for two reasons. First, they will identify the effect of SARS-CoV-2 infection on plaque inflammation and atherosclerosis progression and determine whether these effects are mediated by a new SARS-CoV-2 entry factor. Secondly, they will determine how noninfectious viral debris contribute to plaque inflammation and aggravated atherosclerosis and whether their persistence constitutes the molecular basis for the increased risk of long term CV events.

PI_NAMEs: GIANNARELLI, CHIARA  (contact)

PROGRAM_OFFICER_NAME: OLIVE, MICHELLE

PROJECT_TERMS: 2019-nCoV;ACE2;Acute;acute coronary syndrome;acute infection;Adverse effects;Affect;Anti-viral Agents;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Autopsy;biobank;Biological Assay;Blood;Blood Vessels;Bone Marrow;cardiovascular risk factor;Cardiovascular system;Cells;Circulation;Clinical Sciences;clinically relevant;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 patient;COVID-19 treatment;cytokine;Data;design;Detection;Disease Progression;Event;Exposure to;fluorodeoxyglucose;Foam Cells;Future;Gene Transfer;global health;Goals;Hamsters;Heart;Hematopoietic;Histologic;Human;human data;human model;human RNA sequencing;Immune;Immune response;Immunofluorescence Immunologic;indexing;individualized medicine;Infection;Inflammation;Inflammatory;Inflammatory Response;Interleukin-6;Knowledge;lipid metabolism;Lung;Macrophage;Measures;Mediating;Medical center;Mesocricetus auratus;Modeling;Molecular;molecular targeted therapies;molnupiravir;Monitor;Myocardial Infarction;Neuropilin-1;New York City;Nucleocapsid;olfactory bulb;Organ;Outcome;Patients;PET/CT scan;Post-Acute Sequelae of SARS-CoV-2 Infection;prevent;prospective;Proteins;PTPRC gene;Public Health;receptor;Recovery;Resolution;Risk;Role;Sampling;SARS-CoV-2 infection;SARS-CoV-2 spike protein;single cell analysis;single-cell RNA sequencing;small molecule inhibitor;Spleen;Stroke;systemic inflammatory response;Testing;Tissues;transcriptome;United States National Institutes of Health;vaccine development;Viral;viral RNA;Virus;Virus Replication;western diet;Work;X-Ray Computed Tomography

PROJECT_TITLE: Mechanisms of atherosclerotic cardiovascular complications in COVID19

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE The postdoctoral training program in Clinical Therapeutics is the core function of the Committee on Clinical Pharmacology and Pharmacogenomics at The University of Chicago and the educational component within the Center for Personalized Therapeutics. The program provides an infrastructure for training of both clinicians and translational scientists in clinical pharmacology, therapeutics, and pharmacogenomics. Upon completion of the program, trainees are expected to become accomplished in basic research methodology, experimental design, and data interpretation and presentation, and be prepared for a competitive research career, as well as certification in Clinical Pharmacology (licensed physicians) or accredited in Applied Pharmacology (non- physicians or non-licensed physicians) by the American Board of Clinical Pharmacology.

PI_NAMEs: DOLAN, MARY EILEEN;O'DONNELL, PETER HUGH (contact);RATAIN, MARK J

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Clinical;Therapeutic

PROJECT_TITLE: Clinical Therapeutics


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Infectious Diseases;Inflammatory Bowel Disease;Neurosciences

ORG_CITY: PULLMAN

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: Project Narrative We propose to investigate how the nervous system and immune system interact to achieve the resolution of infection and the specificity of innate immunity, two important but poorly understood issues in immunology. Failure to properly resolve infection or to ensure appropriate innate immune responses to specific pathogens can lead to uncontrolled inflammation, which has now been recognized as a unifying mechanism for many inflammatory diseases, such as arthritis, sepsis, and inflammatory bowel disease. Understanding the molecular and neuronal mechanisms responsible for neural regulation of both infection resolution and innate immune specificity could benefit the development of new treatments for infectious diseases and innate immune disorders.

PI_NAMEs: SUN, JINGRU  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Arthritis;Back;Biological Models;Caenorhabditis elegans;Development;Disease;Ensure;environmental change;Failure;G-Protein-Coupled Receptors;Heart Rate;Homeostasis;Human;Immune;Immune response;Immune system;Immune System Diseases;Immunity;Immunologics;Immunology;improved;Infection;infectious disease treatment;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Innate Immune Response;Mediating;Molecular;Natural Immunity;Nervous System;Nervous System control;neural network;Neurobiology;Neuroimmune;Neurons;neuroregulation;neurotransmission;pathogen;Research;Resolution;Sepsis;Specificity;theories

PROJECT_TITLE: Neuronal and molecular mechanisms underlying neural regulation of innate immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: Chicago

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: NARRATIVE The dynamic accessibility of chromatin is key to understanding regulatory capacity of the genome. We will combine optical genetics, imaging and high throughput sequencing tools to develop a novel technology to characterize the native landscape of accessible genome in living cells. This technology will enable us to gain new insight into the organizing principles of supranucleosomal conformation during cell state transition.

PI_NAMEs: WANG, XIAOZHONG ALEC (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Architecture;ATAC-seq;Binding;biophysical properties;Biophysics;Cell Differentiation process;cell fixing;Cells;Characteristics;Charge;Chromatin;Chromosomes;computational pipelines;computerized data processing;Coupled;crosslink;Crowding;Data Set;design;Detergents;Digestion;Disease;DNA;DNase I hypersensitive sites sequencing;embryonic stem cell;Enhancers;Environment;enzyme activity;Epiblast;epigenomics;Exhibits;Experimental Designs;Gene Expression;Genetic;Genome;genome-wide;Genomic DNA;Genomics;High-Throughput DNA Sequencing;High-Throughput Nucleotide Sequencing;Histones;Image;imaging study;In Situ;in vitro Model;indexing;insight;Interphase;Light;Liquid substance;Maps;Measures;Methods;Micrococcal nuclease digestion of chromatin followed by sequencing;Mitosis;Mitotic Chromosome;Modeling;Molecular;Molecular Conformation;Molecular Probes;Mouse Embryonic Stem Cells;Mus;Names;new technology;next generation sequencing;novel;novel strategies;nuclease;Nucleoplasm;Nucleosomes;Optics;optogenetics;Permeability;Physical condensation;Procedures;promoter;Protocols documentation;prototype;recruit;Regulatory Element;Role;sample fixation;Structure;System;Techniques;Technology;technology development;Testing;tool;Tracer;Validation;virtual

PROJECT_TITLE: Optogenomic mapping of chromatin accessibility in live cells

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE This project aims to develop novel molecular risk models that will identify and integrate drivers of resistance to decrease the likelihood of ALL relapse. Comprehensive resistance drivers will be identified by innovative analysis of coding and non-coding regions of the human genome in large cohort of relapse specimens. The novel molecular risk models will be built by comparing the frequency profiles of resistance drivers detected at diagnosis between patients who have relapsed and those who are cured.

PI_NAMEs: MA, XIAOTU  (contact)

PROGRAM_OFFICER_NAME: BHARTI, SANITA

PROJECT_TERMS: Acute Lymphocytic Leukemia;Affect;Algorithms;Biological Assay;Blood;cancer cell;Cancer Etiology;Cells;Cessation of life;chemotherapy;Child;Childhood Acute Lymphocytic Leukemia;Clinical Research;Clinical Trials;Clinical Trials Cooperative Group;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;Collaborations;Coupled;Cytotoxic Chemotherapy;Data;deep sequencing;design;Detection;Diagnosis;Disease remission;Dominant Genetic Conditions;efficacy testing;empowerment;Ensure;Event;experience;Frequencies;Future;Genome;genome sequencing;Genomics;Goals;Hand;Heart failure;high risk;Human Genome;Immunotherapy;improved;improved outcome;Incidence;Infertility;innovation;insight;Knowledge;knowledge integration;Late Effects;leukemia relapse;Malignant Childhood Neoplasm;Measures;Methods;Modeling;Molecular;Newly Diagnosed;novel;novel therapeutics;Open Reading Frames;Outcome;Patients;Pattern;Pediatric Oncology Group;Prevalence;prognostic;prospective;Proteins;rare variant;Relapse;relapse patients;relapse risk;Residual Cancers;Residual Neoplasm;Resistance;Resistance profile;Resources;Retrospective Studies;Risk;risk minimization;risk prediction;risk stratification;Saint Jude Children's Research Hospital;Secure;single cell sequencing;Specimen;Survival Rate;Technology;Testing;Therapeutic Agents;therapy resistant;Time;transcriptome sequencing;treatment response;tumor;Untranslated RNA;Variant

PROJECT_TITLE: Tracking Therapy-Resistant Alterations in Childhood Acute Lymphoblastic Leukemia

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Immunotherapy;Neurosciences;Rare Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE More effective therapies are needed for malignant gliomas as most patients will ultimately relapse despite surgery, radiation, and chemotherapy. Our preliminary work shows that gliomas carrying mutations in the ATRX gene have activation of a range of innate immune responses and are selectively sensitive to double-stranded RNA (dsRNA)-based immune therapies. Our proposal will define the role of ATRX mutations in mediating innate immune responses in the tumor and its microenvironment, and also explore the potential of dsRNA-based agonists as promising therapies for ATRX-mutant gliomas.

PI_NAMEs: ASHLEY, DAVID M. (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: 19q;Adaptive Immune System;Affect;Aftercare;Agonist;Astrocytoma;cancer type;Cartoons;Cell Line;Cells;Chemosensitization;chemotherapy;Chromatin;chromatin remodeling;Chromosomes;cohort;cytokine;Data;Dependence;Double-Stranded RNA;effective therapy;Gene Expression;Gene Proteins;Glioma;Goals;Human;Immune;immune activation;immune cell infiltrate;Immune checkpoint inhibitor;Immune Response Genes;Immune signaling;Immune system;Immunobiology;Immunologic Surveillance;Immunologics;Immunotherapeutic agent;Immunotherapy;in vivo;Inflammation;Inflammatory;inhibitor;Innate Immune Response;Innate Immune System;innovation;insight;Interferon Type I;Knock-out;Knockout Mice;Link;link protein;Malignant - descriptor;Malignant Glioma;Measures;Mediating;member;Modeling;Molecular Profiling;Mus;mutant;Mutate;Mutation;Natural Immunity;neoplastic cell;nondeletion type alpha-thalassemia/mental retardation syndrome;novel;oligodendroglioma;Operative Surgical Procedures;Patients;Poly ICLC;pre-clinical;Primary Brain Neoplasms;Production;Protein Deficiency;Proteins;Radiation;Radiation therapy;Relapse;resistance mechanism;response;RNA;Role;Signal Transduction;Specimen;SWI/SNF Family Complex;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic evaluation;therapy design;Time;Tissues;TP53 gene;tumor;Tumor Escape;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;tumor-immune system interactions;Work

PROJECT_TITLE: ATRX mutations, innate immune activation and therapeutic vulnerability in malignant gliomas

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Horizontal gene transfer, which refers to the direct transfer of genetic material between bacterial cells, is an important way that pathogens evolve and has been implicated in a wide variety of infectious diseases. However, we don’t yet fully understand how different genetic and environmental factors influence the overall success and consequences of gene transfer events, especially in the time window immediately after these events occur. This proposal uses both computational and experimental methods to tease apart these relationships; ultimately, we hope to be able to predict high-risk gene transfer (e.g., to new/emerging pathogens) before it occurs, thereby allowing us to explore novel control and treatment strategies.

PI_NAMEs: LOPATKIN, ALLISON  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Address;Antibiotic Resistance;Antibiotic Therapy;Bioinformatics;Bioremediations;Cells;Clinical;clinically relevant;Communicable Diseases;Computer Models;cost;Distant;driving force;emerging pathogen;Environment;Environmental Risk Factor;Epidemiologic Monitoring;Event;Evolution;experimental study;fitness;Gene Transfer;Genetic;Genetic Materials;Geography;Goals;Health;high risk;Horizontal Gene Transfer;Human;In Situ;Individual;Industrialization;insight;Mediating;Metabolic;Methods;microbial;microbiome research;Minority;Mission;Molecular;Multi-Drug Resistance;National Institute of General Medical Sciences;novel;Partner in relationship;pathogen;Pathogenesis;Plasmids;Population;Prevalence;Process;programs;Research;resistance gene;success;Time;trait;treatment strategy;Virulence;Work

PROJECT_TITLE: Determinants underlying horizontal gene transfer-mediated pathogen success

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Chronic Pain;Neurosciences;Pain Research;Urologic Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Urinary bladder function and responses to insults depend on inputs from afferent nerve fibers located in the bladder mucosa and musculature. Our work is focused on understanding how acid-sensing ion channels operate to control the transmission of sensory information arising from the urinary bladder. The results of this research will provide information that might help to design new therapies to treat visceral pain.

PI_NAMEs: CARATTINO, MARCELO DANIEL (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Action Potentials;afferent nerve;Afferent Neurons;Afferent Pathways;ASIC channel;Binding;Bladder;Bladder Control;Bladder mucosa;bladder pain;C Fiber;Calmodulin;Chemicals;Chronic;chronic pain;Collection;Complex;Coupled;Cyclophosphamide;Cystitis;Data;design;Development;Esthesia;Event;experimental study;Exposure to;extracellular;Fiber;Frequencies;Genetic;Image;Inflammation;Injury;insight;intravesical;Ion Channel Gating;Knockout Mice;Ligands;Mechanical Stimulation;mechanical stimulus;Mediating;medical attention;Membrane;Modeling;Molecular;Mus;Nerve Fibers;Nociception;nociceptive response;novel;novel therapeutics;overexpression;Pain;pain behavior;Pain Disorder;patch clamp;Pathway interactions;Patients;Peripheral;Peripheral Nerves;pharmacologic;Physiological;Pilot Projects;Play;pressure;prevent;Process;Protons;receptor;Reporting;Research;response;Role;Sensory;Signal Transduction;Source;Stretching;Testing;Tissues;tool;Transgenic Mice;transmission process;Urination;Visceral Afferents;Visceral pain;voltage;Work

PROJECT_TITLE: Role of acid-sensing ion channels in bladder sensory signaling

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Chronic Pain;Complementary and Integrative Health;Genetics;Interstitial Cystitis;Microbiome;Neurosciences;Pain Research;Urologic Diseases

ORG_DEPT: UROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Chronic pelvic pain is debilitating and afflicts millions of patients in the U.S. Microglia are CNS immune cells that play significant roles in pain and are poised to respond to changes in microbiota. We will evaluate the role of microglia responses to microbiota in clinically-relevant models of pelvic pain. This groundwork will provide biomarkers for identifying patients amenable to dysbiosis-targeted therapies, demonstrate the feasibility of microglia-targeted therapies, and identify new probiotics for chronic pelvic pain.

PI_NAMEs: KLUMPP, DAVID J (contact)

PROJECT_TERMS: Ablation;Acute Pain;attenuation;Biological Markers;Biological Process;Cells;chronic pain;chronic pelvic pain;Chronic Prostatitis;Circulation;Clinic;Clinical;clinically relevant;cognitive function;conditional knockout;Cues;Data;Development;Diagnosis;Disease;dysbiosis;effective therapy;Endotoxins;Etiology;Exhibits;fecal transplantation;Female;Fostering;Future;Gene Expression;Genetic;genetic approach;Genetic Predisposition to Disease;glial activation;gut dysbiosis;gut microbiota;Immune;In Vitro;in vivo;Infection;innovation;Interstitial Cystitis;Knockout Mice;Leaky Gut;Mediating;Mediator;men;microbial;microbial products;microbiome;microbiota;Microglia;Modeling;Morbidity - disease rate;Morphology;mouse model;Mus;Neurons;novel;Pain;pain behavior;pain patient;pain score;Pathogenesis;Pathogenicity;Patients;Pelvic Pain;pharmacologic;Phenotype;Play;pre-clinical;probiotic therapy;Probiotics;Reporting;response;Rodent;Rodent Model;Role;Serum;Signal Transduction;Site;Symptoms;targeted treatment;Testing;TLR4 gene;Toll-like receptors;transcriptome sequencing;Transducers;treatment strategy;urologic;urologic chronic pelvic pain syndrome

PROJECT_TITLE: TLR Transduction of Dysbiotic Pelvic Pain


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Natural Products

ORG_CITY: CORVALLIS

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: Proteins that are secreted from cells or located at cellular membranes represent about 39% of the human proteome and the cellular pathway for production and secretion of proteins is emerging as an important therapeutic target relevant to cancer, neurodegeneration and inflammatory diseases. A small group of macrocyclic natural products have been identified as potent and selective agents that modulate the protein secretory pathway in discrete ways, although how they work is not well understood. Discovery of new secretory pathway inhibitors, and elucidation and comparison of their specific action, is expected to allow targeted manipulation of this pathway, leading to the development of new therapeutic agents for chronic diseases.

PI_NAMEs: ISHMAEL, JANE E;MCPHAIL, KERRY LEIGH (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Binding;Biogenesis;Biological Assay;Cell secretion;Cells;Cellular Membrane;cellular targeting;chemical synthesis;Chemicals;cheminformatics;Chronic Disease;Client;Complex;Cryoelectron Microscopy;Cyanobacterium;Cytosol;Databases;Development;Diabetes Mellitus;Dimensions;Disease;Docking;Elements;Eukaryotic Cell;Family;fungus;Future;Goals;Homeostasis;Human;human disease;Inflammatory;inhibitor;interdisciplinary approach;Knowledge;Lateral;Length;Libraries;Ligand Binding;Ligands;lipophilicity;Luciferases;Maintenance;Malignant Neoplasms;Mammalian Cell;Membrane;Membrane Proteins;metabolomics;Modeling;Molecular;Multi-Institutional Clinical Trial;Natural product discovery;Natural Products;Nature;Nerve Degeneration;NMR Spectroscopy;novel therapeutics;Organism;pathogenic bacteria;Pathway interactions;Peptide Synthesis;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;Phenotype;Physiological;polypeptide;Process;Production;Protein Biosynthesis;Protein Dynamics;Protein Import;Protein Inhibition;Protein Secretion;Proteins;Proteome;proteostasis;Reporter;Resolution;Ribosomes;scaffold;Scheme;screening;secretory protein;Series;small molecule;Solid;Solid Neoplasm;structural biology;Structure;Structure-Activity Relationship;Substrate Specificity;Testing;Therapeutic;Therapeutic Agents;therapeutic target;tool;Toxic effect;Translating;Translations;Variant;Work;Yeasts

PROJECT_TITLE: Modulation of Protein Biogenesis and Secretion by Natural Product Translocon Ligands

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]