NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: LOS ANGELES

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE/ RELEVANCE TO PUBLIC HEALTH Older individuals respond poorly to infectious agents/vaccines due, in part, to aging of the immune system (immunosenescence), a process accelerated in HIV+ individuals that is poorly understood, especially in the gastrointestinal tract, which houses more than 60% of the body’s immune cells. In this study, we aim to understand the effects of aging alone and in combination with chronic HIV infection in mucosal B-cells by studying humoral immunity to SARS-CoV2. This is of great importance as it will aid to identify possible therapies to slow or improve immunosenescence.

PI_NAMEs: EPELDEGUI, MARTA  (contact);YANG, OTTO O

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: 2019-nCoV;Acceleration;Acute;adaptive immunity;Affect;Affinity;Age;age acceleration;age difference;age effect;age related;Aging;Antibodies;Antibody Formation;Antibody Response;antigen challenge;Antigen Presentation;Antigens;antiretroviral therapy;Automobile Driving;B-Cell Antigen Receptor;B-Lymphocytes;Bacteria;Bacterial Translocation;Biological Assay;Biological Models;Blood;Cardiovascular Diseases;CD4 Positive T Lymphocytes;Cell Aging;Cell Maturation;Cells;Cellular Immunity;Chronic;chronic infection;Circulation;Clinical;Clonal Expansion;comorbidity;Complex;COVID-19;Cytomegalovirus;cytotoxic;Data;effector T cell;Ensure;exhaust;Exhibits;Exposure to;frailty;Frequencies;gastrointestinal;Gastrointestinal tract structure;Goals;Gut associated lymphoid tissue;gut microbiome;Gut Mucosa;Haemophilus influenzae;Helper-Inducer T-Lymphocyte;HIV;HIV Infections;HIV-1;Human;Humoral Immunities;Immune;immune activation;immune function;Immune response;Immune system;Immune System Diseases;Immunity;Immunoglobulin Class Switching;Immunoglobulin M;Immunoglobulin-Secreting Cells;Immunologics;immunoregulation;immunosenescence;improved;Individual;Infection;Infectious Agent;Inflammaging;Inflammation;Inflammatory;Life Expectancy;Literature;Lymphocyte;Lymphoid Tissue;Maintenance;Malignant Neoplasms;Memory;Memory B-Lymphocyte;microbial;Modeling;Moderna COVID-19 vaccine;mucosal HIV infection;Mucous Membrane;neoantigens;normal aging;nutrient absorption;Older Population;pathogen;Pathogenesis;Pathogenicity;peripheral blood;Persons;Pfizer-BioNTech COVID-19 vaccine;Phenotype;Physiological;Plasma;Population;Predisposition;premature;Process;Public Health;Regulation;response;RNA vaccine;Role;Sampling;SARS-CoV-2 immunity;SARS-CoV-2 spike protein;senescence;Sigmoid colon;Site;Study models;Symptoms;T-Cell Depletion;T-Lymphocyte;Testing;Time;Tissues;Vaccinated;Vaccination;vaccine response;Vaccines;Virus;Virus Diseases;Work

PROJECT_TITLE: Mucosal B-cell aging in PLWH

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research;Rehabilitation;Stroke

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The Brain Attack Surveillance in Corpus Christi (BASIC) Project is a long-running biethnic population-based stroke study in a Mexican American and non-Hispanic white population initiated in 2000 with continuous follow- up of mortality and recurrent stroke and with post-stroke cognitive and physical assessments since 2009. Using the rich data in BASIC, the goal of this study is to measure levels of and disparities in life expectancy and cognitively and functionally healthy and unhealthy life years lived after stroke in Mexican American and non-Hispanic white persons, as well as trends in these outcomes. This data is critical to support the growing number of stroke survivors and could inform policies to improve the health of the diverse and aging US population.

PI_NAMEs: LISABETH, LYNDA D (contact);MEHTA, NEIL

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Affect;Age;Age of Onset;Aging;aging in place;Caregiver Burden;Cessation of life;Cognition;Cognitive;Cognitive deficits;cognitive disability;cognitive function;cognitive testing;cost;Data;Death Rate;dementia risk;Dependence;Deterioration;disability;Disparity;disparity reduction;ethnic difference;ethnic disparity;Ethnic Origin;Ethnic Population;experience;follow-up;Future;General Population;Generations;Goals;Health;Health and Retirement Study;Hispanic Americans;Impaired cognition;improved;Individual;innovation;Joints;Latinx population;Life;Life Expectancy;Measures;Medical;Methods;Mexican Americans;Minority;Minority Groups;mortality;mortality risk;motor deficit;Not Hispanic or Latino;Outcome;outcome disparities;Patients;Persons;Physical assessment;physical conditioning;Physical Function;physical impairment;physically handicapped;Play;Policies;Population;population based;post stroke;post stroke cognitive impairment;Quality of life;Recovery;Recurrence;Resources;Respondent;Role;Running;Service provision;Shapes;Societies;Stroke;stroke cognitive outcome;stroke incidence;stroke outcome;stroke survivor;Subgroup;Time;trend;Work

PROJECT_TITLE: Ethnic Differences in Life Expectancy and Cognitively Healthy and Unhealthy Life Years After Stroke

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Microbiome;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: WORCESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative Our gut microbiome has been linked to our susceptibility to Alzheimer's disease, but the complexity of the human microbiome makes it extremely difficult to unravel how individual bacteria influence neurodegeneration. By utilizing the relative simplicity of the Caenorhabitis elegans nervous system and microbiome, we are unraveling the molecular mechanisms of how individual bacterial species suppress neuronal degeneration. Achieving these goals will significantly advance our understanding of how degeneration is regulated by our microbiome, which is critical for developing effective strategies to protect against degenerative diseases, including Alzheimer's disease.

PI_NAMEs: ALKEMA, MARK ;BYRNE, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Adult;Aerobic;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Animal Feed;Animals;Axon;axonal degeneration;Bacteria;Behavior;Biological Models;Caenorhabditis elegans;Choline;cholinergic;Chronic;Citrobacter freundii;Comamonas;Complex;Data;Degenerative Disorder;Development;Diet;Disease;Enzymes;experimental study;feeding;gamma-Aminobutyric Acid;Gene Expression Profile;Genes;Genetic;Goals;gut microbiome;gut microbiota;gut-brain axis;Health;host microbiome;Human;Human Microbiome;human microbiota;improved;Individual;Intestinal Diseases;Intestines;Link;Metabolic;Metabolism;microbiome;microbiota;Modeling;Molecular;Molecular Target;Motor;mutant;Nematoda;Nerve Degeneration;Nervous System;Neurobiology;Neurodegenerative Disorders;Neurons;neuroprotection;neurotransmission;novel;overexpression;Pathway interactions;Physiology;Play;Predisposition;prevent;Protocols documentation;response;Role;screening;Signal Transduction;stool sample;Supplementation;Surveys;tau Proteins;Vitamin B 12

PROJECT_TITLE: How do microbiota determine neuronal function and protect against neurodegeneration?

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Z(55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Dementia;Health Services;Machine Learning and Artificial Intelligence;Nanotechnology;Neurodegenerative;Neurosciences;Prevention;Primary Health Care

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Alzheimer's disease (AD) is a major health crisis, impacting millions of individuals worldwide, and its prevalence is expected to increase significantly by 2050. Current methods for diagnosing AD using positron emission tomography (PET), analysis of cerebrospinal fluid (CSF) or blood biomarkers are expensive, invasive, and limited to specialized healthcare settings, highlighting the need for more accessible and affordable tests. Leveraging our extensive knowledge and experience in developing point-of-care (POC) diagnostics, we propose to develop a sensitive (LoD<10pg/mL), low-cost, easy-to-use, rapid (<30 min) smartphone-based assay to detect amyloid beta (isoforms 42 and 40), phosphorylated tau (isoforms 181, 217, and 231), and Neurofilament Light of the ATN framework in blood/plasma placed on an inexpensive (<$5 material cost), disposable, and mass-producible microfluidic-based cartridge

PI_NAMEs: SHAFIEE, HADI  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: accurate diagnosis;Address;Adult;Advisory Committees;Affect;Algorithms;Alzheimer disease detection;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease blood test;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease test;Alzheimer’s disease biomarker;amnestic mild cognitive impairment;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Artificial Intelligence;beta amyloid pathology;Biological Assay;Biological Markers;biomarker panel;Blood;Blood specimen;blood-based biomarker;Caring;Cellular Phone;Cerebrospinal Fluid;Chemistry;Clinical;clinical diagnosis;Clinical Trials;clinically relevant;Cognitive;cognitive testing;Computer software;cost;cost effective;cost estimate;Cost Savings;deep learning;Dementia;Detection;Development;Diagnosis;diagnostic platform;Diagnostic Procedure;diagnostic strategy;Disease;Disease Management;Disease Progression;drug candidate;Early Diagnosis;Emotional;Ensure;Equipment;experience;Eye;Family;fighting;Financial Hardship;Gases;General Hospitals;Glycerol;Goals;Health;health care settings;Health Services Accessibility;Healthcare Systems;High Prevalence;Home;Hospitals;Hydrogen Peroxide;Image;image processing;Immunoassay;Immunotherapy;Impaired cognition;imprint;improved;Individual;innovation;Knowledge;Label;Light;Machine Learning;magnetic beads;Magnetic nanoparticles;Massachusetts;Measurement;Measures;Methodology;Methods;microchip;Microfluidics;Monitor;nanoparticle;nanoprobe;Nanotechnology;Nerve Degeneration;Neurodegenerative Disorders;neurofilament;neuroimaging;novel therapeutics;Optics;Participant;Pathologic;Patient Care;Patients;Performance;Physiological;Plasma;Platinum;point of care;point of care testing;point-of-care detection;point-of-care diagnostics;Positron-Emission Tomography;Prevalence;Primary Care;primary care setting;Procedures;Prognosis;Protein Isoforms;Research;Sample Size;Sampling;screening;Senile Plaques;Signal Transduction;Site;smartphone application;Specialist;Surface;Symptoms;System;targeted biomarker;tau Proteins;tau-1;Telephone;Testing;Time;tool;Treatment Efficacy;United States;user-friendly;Visit;Wait Time;Water;Woman

PROJECT_TITLE: Blood-based Alzheimer's biomarker detection at the point of care

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging

ORG_CITY: Chicago

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative Aging is a process with which all organisms must contend, and mitochondria are a fundamental factor in both upstream and downstream events of cellular aging. However, many aging hypotheses related to mitochondria have remained unsolved, because our ability to control and track individual mitochondria and their morphology, genomes, functions, and interactions with other organelles as cells age has been limited. The goal of the proposed work is to implement powerful molecular and single-cell techniques in combination with in silico modeling approaches to address these limitations and gain new mechanistic insights into the role of mitochondria in cellular aging.

PI_NAMEs: KOSLOVER, ELENA FABRIKANT;LACKNER, LAURA L (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Address;Age;age related changes;Aging;aging reversal;Biological Assay;Biological Models;Biology;Cardiolipins;Carrier Proteins;cell age;Cell Aging;Cell Cycle;Cell Death;Cell Differentiation process;cell growth;Cell Physiology;Cells;Cellular biology;Collaborations;Computer Models;Computer Simulation;Daughter;daughter cell;drivers of aging;Event;experience;experimental study;fitness;functional decline;Generations;Genome;Goals;Human;Image;in silico;Individual;innovation;insight;Investigation;Link;Lipids;live cell imaging;Maintenance;Measures;Membrane;Methods;Microfluidics;Mitochondria;Mitochondrial DNA;Mitochondrial Inheritance;Modeling;Molecular;Molecular Biology;molecular modeling;Morphology;Mothers;mutant;novel;novel therapeutic intervention;Organelles;Organism;Oxidation-Reduction;Physiological;Play;Positioning Attribute;predictive modeling;Process;Proteins;Research;Role;segregation;simulation;System;Techniques;Testing;tool;Vacuole;Visualization;Work;Yeasts

PROJECT_TITLE: Interdisciplinary investigation of functional asymmetry and topological restructuring in mitochondrial networks during cellular aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Aging;Genetics;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE  We recently showed that hypoxia reverses disease in a mouse model of mitochondrial electron transport chain complex 1 deficiency. We now propose comprehensively and mechanistically studying the ability of hypoxia to rescue a mouse model of impaired mitochondrial proteostasis.

PI_NAMEs: JAIN, ISHA HIMANI (contact)

PROJECT_TERMS: Affect;aging process;Altitude;anaerobic glycolysis;Behavior;Biological Markers;Brain region;Breathing;Bypass;Cell Respiration;Chronic;clinical application;Complex;CRISPR screen;Data;Defect;design;Disease;Dose;Electron Transport;Environment;Exposure to;extend lifespan;Functional disorder;Genetic;Genetic Diseases;genome-wide;Goals;healthy volunteer;HTRA2 gene;Human;Hypoxia;Hypoxia Inducible Factor;Impairment;inhibitor;insight;interest;Iron;K562 Cells;Knockout Mice;Lesion;loss of function mutation;Mediating;Metabolic;Mitochondria;Mitochondrial Diseases;mitochondrial dysfunction;Mitochondrial Electron Transport Chain Deficiencies;Modeling;Molecular Chaperones;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Nervous System Trauma;nestin protein;Neurologic;neuropathology;normoxia;Oxygen;Pathology;Patients;Peptide Hydrolases;Phase I Clinical Trials;Phenotype;Premature aging syndrome;prevent;protein complex;Proteins;Proteomics;proteostasis;Research;response;Role;small molecule;Sulfur;System;Testing;transcription factor;Treatment Protocols;treatment strategy;Work

PROJECT_TITLE: A Translatable Form of Hypoxia Therapy for Impaired Mitochondrial Proteostasis

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ORG_CITY: BRONX

ORG_DEPT: GENETICS

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Our research holds significant public health relevance as we aim to investigate the genetic foundations of the loss of chromosome Y (LOY) and its connections to the aging process. This exploration is pivotal for deciphering LOY's role in the susceptibility to diseases linked with aging. Directly aligning with the NIA's mission, our study seeks to cultivate foundational insights that can mitigate the challenges and disabilities humans face in their later years.

PI_NAMEs: BARZILAI, NIR J;ZHANG, ZHENGDONG  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Age;Age of Onset;age related;Age related macular degeneration;Age related pathologies;age-related disease;Aging;aging biomarker;aging process;aging related;Alzheimer's Disease;Appearance;Area;Bayesian Analysis;Binding;Breast Cancer Risk Factor;Calibration;Cardiovascular system;CD14 gene;Cell Aging;cell behavior;Cell Cycle;Cell Fraction;Cells;Chromosome abnormality;chromosome Y loss;Chronology;Code;cohort;Complex;Computing Methodologies;Data;Data Set;disability;Disease;Disease susceptibility;Diving;DNA Damage;DNA polymerase gamma;DNA Primase;DNA Sequence Alteration;DNA-Directed DNA Polymerase;Elderly;Elderly man;Event;Exhibits;exome sequencing;extreme human longevity;Face;Fibroblasts;Fluorescent in Situ Hybridization;Foundations;Frequencies;Functional disorder;Gene Frequency;Genes;Genetic;Genetic Markers;Genetic Risk;genetic variant;Genome;Genome Stability;genome wide association study;Genomic Instability;Genomics;Genotype;Goals;Health;Human;Human Genome;Individual;innovation;insight;Leukocytes;Life Expectancy;Link;Longevity;Maintenance;male;Mechanics;men;Menopause;Methodology;Methods;Mission;Mitochondria;mitochondrial genome;Modeling;Mosaicism;multi-ethnic;Mutation;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;older men;Pathway interactions;Physiological;Play;polygenic risk score;Predisposition;Process;public health relevance;Random Allocation;rare variant;Research;Resolution;response;Rest;Risk;risk variant;Role;Sampling;Shapes;SNP array;Somatic Cell;Somatic Mutation;statistics;stem;stem cells;Stress;Testing;Therapeutic;Variant;whole genome;Woman

PROJECT_TITLE: Loss of the Y Chromosome and Its Implications in Aging

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Physical Rehabilitation;Prevention;Rehabilitation;Sarcopenia

ORG_CITY: WASHINGTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Precise optical scanning of 3D whole body shape is now possible with a variety of widely available commodity devices. These affordable and accessible scans may hold untapped wealth of health-related information that can be used with machine learning. In this proposal, we use this technology to develop low-cost, convenient, widely available, and accurate approaches that can augment care of older adults, and in particular for the care of individuals with sarcopenia and obesity.

PI_NAMEs: HAHN, JAMES K (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: 3-Dimensional;Address;adverse outcome;age effect;age related;Agreement;Algorithms;artificial intelligence algorithm;Bedside Technology;Body Composition;Businesses;Caring;Cessation of life;Clinical;clinical application;clinical care;clinical practice;Clinical Trials;Cohort Studies;Communities;convolutional neural network;cost;cost effective;Creatine;Cross-Sectional Studies;Data;Devices;Diagnosis;diagnostic accuracy;dietary;disability;Disabling;Disparity;Dual-Energy X-Ray Absorptiometry;Early Diagnosis;early screening;empowerment;Exercise;Fatty acid glycerol esters;Fatty Liver;Foundations;functional decline;Health;Health Care Costs;Healthcare;Home;human old age (65+);Image;imaging modality;improved;Individual;Intervention;Machine Learning;machine learning algorithm;machine learning prediction algorithm;Magnetic Resonance Imaging;Measurable;Measures;Methodology;Methods;mobile application;mobile computing;Modality;Morbidity - disease rate;multimodality;multitask;muscle form;Muscle function;Nature;neural network algorithm;novel;Nursing Homes;Obesity;older adult;Optics;Outcome;Participant;Patient Recruitments;pharmacologic;Phenotype;Physical Function;Population;prediction algorithm;Prevalence;prevent;programs;prototype;reduced muscle mass;Research;Resources;Risk;risk mitigation;sarcopenia;sarcopenic obesity;Scanning;shape analysis;Shapes;Syndrome;System;Technology;Technology Transfer;Testing;Time;Training;Translating;treatment strategy;United States;usability;user centered design;Validation;Visceral;Work;X-Ray Computed Tomography;young adult

PROJECT_TITLE: 3D body shape analysis for predicting sarcopenia and obesity in older adults

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Nashville

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative The proposed project aims to understand the role of social networks in the etiology of health and health risk behaviors in the older never-married (ONM) population. We will identify intra- and interpersonal mechanisms underlying the role of social networks by collecting and analyzing the first-ever nationally representative survey data on ONM adults across two-time points. Results from this study will address a crucial unmet need for researchers and policymakers, guiding interventions to enhance the quality of life for the ONM population, while addressing the challenges they introduce to their social circles and the broader healthcare system.

PI_NAMEs: SONG, LIJUN  (contact)

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: Address;Adult;Affect;age-related disease;aged;Aging;aging process;Attention;Baseline Surveys;Behavior;behavior change;Characteristics;Cognitive;Collection;Complex;Costs and Benefits;Data;Data Collection;Data Set;density;Development;Disadvantaged;Documentation;drinking;Epidemiology;Etiology;family caregiving;Growth;Health;Healthcare;Healthcare Systems;Individual;instrument;Intervention;Investigation;Knowledge;Life;Link;Literature;Loneliness;Long-Term Care;Maps;Marriage;Measurement;Mediating;men;Methods;Modeling;Never Married;older adult;Outcome;Pathway interactions;physical inactivity;Policy Maker;Population;population based;Portraits;prospective;Psyche structure;Quality of life;Regression Analysis;Research;Research Personnel;resilience;response;Risk;Risk Behaviors;Role;Sample Size;Sampling;Science;Shapes;Smoking;social;Social Controls;social engagement;Social Network;Social support;sociodemographics;Socioeconomic Factors;Socioeconomic Status;Subgroup;Surveys;Testing;theories;Time;Woman

PROJECT_TITLE: National Study of Older Never-Married Adults


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Narrative One of the major obstacles to developing effective treatments for neurodegenerative diseases has been a paucity of genetic targets against which to direct therapeutic efforts. Recent human studies have revealed a robust and reproducible link between polymorphism in the Ms4a family of genes and Alzheimer’s Disease and related neurodegenerative disorders. Here, we will characterize the role of Ms4a genes in neurodegenerative pathogenesis and elucidate the mechanisms by which Ms4a genes regulate neurodegenerative processes.

PI_NAMEs: GREER, PAUL LIEBERMAN (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Behavioral;Biological Assay;Candidate Disease Gene;Cognitive;conditional knockout;Data;Degenerative Disorder;Disease;DNA Sequence Alteration;DNA sequencing;effective therapy;experimental study;Family member;Frontotemporal Dementia;Gene Family;Genes;Genetic;Genetic Polymorphism;Genetic study;Human;Human Genetics;improved;Individual;insight;Knockout Mice;Knowledge;Laboratories;Link;Mediating;member;Membrane;Microglia;mouse genetics;mouse model;Multigene Family;Multiple Sclerosis;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;new therapeutic target;novel;novel strategies;novel therapeutics;Pathogenesis;Pathology;Phenotype;Play;Predisposition;Process;Reagent;Reproducibility;Research;Risk;Role;stem;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Work

PROJECT_TITLE: Elucidation of the mechanisms by which Ms4a genes regulate neurodegeneration in Alzheimer’s Disease and related disorders

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;HIV/AIDS;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_NAME: GEORGETOWN UNIVERSITY

PHR: PROJECT NARRATIVE Using a multidisciplinary approach, this cross-sectional and longitudinal study aims to investigate the impact of Alzheimer’s disease (AD) risk genes and their interactions with HIV disease severity in older Blacks/African Americans living with HIV, who may be at a greater risk of developing Alzheimer’s disease and related dementias (ADRD) later in life.

PI_NAMEs: JIANG, XIONG  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Accounting;Address;Affect;African American;African American population;aging demography;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Back;Black Populations;Brain;Brain Diseases;Brain region;caudate nucleus;clinical diagnosis;cognitive performance;cohort;Data;Dementia;Deposition;Diffusion Magnetic Resonance Imaging;Disease;Disease Marker;disease phenotype;Disease Progression;Elderly;Enrollment;Episodic memory;executive function;Functional Magnetic Resonance Imaging;genetic risk factor;Genetic Variation;Goals;high risk;Hippocampus;HIV;HIV Seronegativity;HIV-1;HIV-2;HIV-associated neurocognitive disorder;Imaging Techniques;Immunosuppression;Impaired cognition;Individual;interdisciplinary approach;interest;Knowledge;Life;Link;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Measures;medial temporal lobe;Memory;mild cognitive impairment;multidisciplinary;Multimodal Imaging;multimodality;nerve injury;neural;Neuropsychological Tests;Neuropsychology;Not Hispanic or Latino;Observational Study;older adult;Participant;Pathology;Persons;Phenotype;Plasma;Play;Population Heterogeneity;Positron-Emission Tomography;Prevalence;Probability;Public Health;Recording of previous events;Research;research clinical testing;response;Rest;Risk;Risk Factors;risk variant;Role;Severity of illness;Signal Transduction;Structure;Subgroup;success;tau Proteins;Techniques;Underrepresented Populations;Visit;Vulnerable Populations;β-amyloid burden

PROJECT_TITLE: A multidisciplinary study of Alzheimer's disease risk factors in Blacks/African Americans living with HIV

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Progranulin mutations cause frontotemporal dementia (FTD), a devastating disease for which no cure currently exists. In this project, we will test a novel therapeutic approach that uses antisense oligonucleotides (ASOs) to restore normal progranulin levels in a humanized progranulin-deficient mouse model of FTD. Additionally, we will define the timing window for effective ASO treatment, as well test for potential off-target effects for lead ASOs.

PI_NAMEs: NGUYEN, ANDREW D. (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: 3' Untranslated Regions;Address;Affect;Alleles;Amyotrophic Lateral Sclerosis;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Applications Grants;Astrocytes;Base Pairing;behavior test;Behavioral;Binding;Binding Sites;Body Weight;Brain;causal variant;Cells;Cysteine;Data;design;Development;Diagnosis;Disease;Dose;effectiveness evaluation;Evaluation;Foundations;Frameshift Mutation;Frontotemporal Dementia;Gangliosides;Gene Expression;Goals;Government;granulin;Heterozygote;Human;humanized mouse;Hyperactivity;improved;in vivo evaluation;Induced pluripotent stem cell derived neurons;innovation;insight;Laboratory Study;Lead;lipidomics;Lipids;Memory;Messenger RNA;Microglia;MicroRNAs;Modality;Molecular;mouse model;mRNA Decay;multidisciplinary;Mus;Mutation;Nervous System Disorder;neuroinflammation;Neurons;Nonsense Mutation;novel;novel strategies;novel therapeutic intervention;Persons;PGRN gene;Phenotype;pre-clinical;prevent;Protein Secretion;Proteins;repetitive behavior;Reporting;Research;Research Personnel;RNA;RNA Sequences;RNA Splicing;screening;Solid;Spinal Muscular Atrophy;Testing;Therapeutic;tool;transcriptome sequencing;transcriptomics;Translational Repression;Translations;Untranslated RNA;Work

PROJECT_TITLE: Antisense Oligonucleotides for Progranulin-deficient Frontotemporal Dementia

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;HIV/AIDS

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PI_NAMEs: EARP, H. SHELTON (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: anti-cancer research;Area;Award;Basic Science;Budgets;Cancer Center;Cancer Center Support Grant;cancer education;career;Catchment Area;Clinical Sciences;Committee Membership;Communication;Communities;community advisory board;community engagement;Community Outreach;Comprehensive Cancer Center;computer network;Contracts;Development;Education;Ensure;Equipment;Evaluation;experience;Faculty;Fostering;Funding;Funding Opportunities;Grant;HIV;Human Resources;Informatics;Information Technology;Infrastructure;innovation;Institution;Leadership;Malignant Neoplasms;meetings;member;Mentors;Mission;Monitor;NCI Center for Cancer Research;North Carolina;operation;Output;Patient advocacy;Population Sciences;Process;programs;Recommendation;recruit;Recurrence;Reporting;Research;Research Activity;Resource Sharing;Resources;Sampling;Services;Strategic Planning;Surveys;symposium;Training;Training and Education;translational cancer research;Translational Research;UNC Lineberger Comprehensive Cancer Center;United States National Institutes of Health;Universities;Vision;Wages;Work

PROJECT_TITLE: Admin-Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Health Services;Rehabilitation

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PI_NAMEs: CAPLAN, STEVEN H (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Cancer Center;cancer survivorship care;cell fixing;Cells;Communities;Consultations;Core Facility;Coupled;Data;Dedications;design;Development;experimental study;Fees;Goals;Image;Image Analysis;image processing;Imaging Techniques;innovation;Laser Scanning Confocal Microscopy;light microscopy;Lighting;live cell imaging;Maintenance;Medical center;member;Methods;Microscope;Microscopic;microscopic imaging;Microscopy;Modeling;molecular imaging;Nebraska;notch protein;Optics;Photobleaching;Publishing;Quality of Care;reconstruction;Research;Research Personnel;Resolution;Resource Sharing;Services;single molecule;Structure;superresolution microscopy;Techniques;Technology;Three-Dimensional Imaging;Tissues;Training;ultra high resolution;Universities

PROJECT_TITLE: Advanced Microscopy Shared Resource

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PI_NAMEs: KLEIN, SABRA L. (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: 2019-nCoV;Antibody Response;biobank;cellular targeting;Collection;Communication;Communities;COVID-19;COVID-19 patient;COVID-19 treatment;COVID-19 vaccine;Data;data dissemination;data sharing;Development;Education;Ensure;Evaluation;Fostering;Funding;Goals;Immune response;Immunity;Information Dissemination;International;Leadership;meetings;Mentors;Molecular Target;outreach;Pathogenesis;Peripheral Blood Mononuclear Cell;Procedures;Productivity;Professional Organizations;Progress Reports;Publications;Research;Research Personnel;Research Project Grants;Sampling;Serology;severe COVID-19;Site Visit;skills;social media;Specimen;T-Lymphocyte;United States National Institutes of Health;Universities;vaccine-induced immunity;web site

PROJECT_TITLE: JH-EPICS Administrative Core


PI_NAMEs: PEKOSZ, ANDREW S. (contact)

PROJECT_TERMS: 2019-nCoV;Amino Acids;Antibody Response;Biological Assay;biosafety level 3 facility;Carbohydrates;Cell Culture Techniques;Cell Line;Cells;Clinical;Complex;Containment;COVID-19;COVID-19 surveillance;Data;Doctor of Philosophy;Ensure;experience;experimental study;Generations;Immunity;improved;Influenza;International;Laboratories;laboratory experience;laboratory facility;Lead;Mammalian Cell;Measures;Methods;milligram;particle;Pathogenesis;Pathology;Peptides;Plaque Assay;Post-Translational Protein Processing;Production;Protein Binding Domain;protein function;protein purification;Proteins;Protocols documentation;Public Health;Reagent;reagent standardization;receptor binding;Recombinant Proteins;repository;Reproducibility;Research Personnel;Research Project Grants;Resources;respiratory virus;response;SARS coronavirus;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Serology;Source;Standardization;T-Lymphocyte;Testing;Time;Universities;Viral Antigens;viral RNA;Virion;virology;Virus;Virus Diseases;Work

PROJECT_TITLE: Virology Resource Core


PI_NAMEs: ZEGER, SCOTT L. (contact)

PROJECT_TERMS: 2019-nCoV;Affect;Age;age difference;Biological;Clinical;Clinical Research;Collaborations;COVID-19;COVID-19 pandemic;COVID-19 patient;Data;design;Disease Progression;economic impact;ethnic difference;Ethnic Origin;Gender;gender difference;Health Services;Hospitals;Human;Immune;immune function;Immune system;Immunity;intersectionality;Intervention;laboratory experiment;Laboratory Study;Measures;men;mortality;Outcome;Pathogenesis;Patients;precision medicine;Race;racial difference;Registries;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Role;SARS-CoV-2 immune response;Severity of illness;sex;social;Social Impacts;Specific qualifier value;Statistical Data Interpretation;Statistical Methods;Statistical Models;Subgroup;Testing;Therapeutic;Time;Woman

PROJECT_TITLE: Analysis Resource Core


PI_NAMEs: COX, ANDREA L (contact)

PROJECT_TERMS: 2019-nCoV;Acute Respiratory Distress Syndrome;anakinra;antagonist;Antibodies;antiviral immunity;Avian Influenza;Biological Assay;Carnitine Palmitoyltransferase I;CASP1 gene;Cell Death;Cell Line;Cell Physiology;Cell surface;cell type;chemokine;chronic infection;Clinical Markers;Clinical Trials;COVID-19;COVID-19 pathogenesis;COVID-19 patient;Critical Illness;cytokine;Data;Disease;Disease Progression;Disease stratification;Endocytosis;Enzymes;Epidemic;experience;fatty acid oxidation;Flow Cytometry;Foundations;Genes;glucose metabolism;Goals;Hepatitis C virus;Hexokinase 2;HIV;Hospitalization;Human;IL18 gene;Immune;Immune response;Immune signaling;Immunity;Impairment;In Vitro;Incubated;Inflammasome;Inflammation;Inflammatory;Influenza;Influenza A Virus, H5N1 Subtype;Influenza A Virus, H7N9 Subtype;influenza virus strain;inhibitor;Interferons;Interleukin Receptor;Interleukin-1 beta;Interleukin-6;Interleukin-8;Interleukins;Intubation;Investigation;Macrophage;Malignant Neoplasms;Measures;Mediating;Metabolic;metabolic profile;Mitochondria;Monoclonal Antibodies;Myeloid Cells;Myeloid-derived suppressor cells;novel;Obesity;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Persons;Plasma;Population;Production;Proteins;Recovery;Research Project Grants;Resources;respiratory infection virus;respiratory virus;response;Role;SARS coronavirus;SARS-CoV-2 antibody;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;severe COVID-19;Severity of illness;Signal Transduction;Simplexvirus;single cell analysis;single-cell RNA sequencing;Stains;targeted treatment;Testing;Therapeutic Intervention;transcriptome sequencing;Viral;Viral Pathogenesis;Virulent;Virus;Virus Diseases;Work

PROJECT_TITLE: Project 1: Mechanisms of innate sensing and pathogenesis of SARS-CoV-2


PI_NAMEs: POWELL, JONATHAN D (contact)

PROJECT_TERMS: 2019-nCoV;Address;antigen-specific T cells;antiviral immunity;Apoptosis;Automobile Driving;Biological Assay;Biological Markers;cancer immunotherapy;Cancer Patient;Carnitine Palmitoyltransferase I;Caspase Inhibitor;Cell Physiology;Cell surface;cell type;Cells;Cellular Assay;Clinical;COVID-19;COVID-19 patient;Critical Illness;Disease;Disease Outcome;effector T cell;Enzymes;Epitopes;fatty acid oxidation;Flow Cytometry;Functional disorder;Generations;Glycolysis;granulocyte;Hexokinase 2;histone methylation;HIV-1;Immune;Immune response;Immune System Diseases;Immunity;Inflammasome;Inflammation;inhibitor;innovation;insight;Link;Lymphopenia;Mediating;Metabolic;Metabolic Marker;Metabolism;methylation biomarker;Mitochondria;Mitochondrial Membrane Protein;Monitor;monocyte;Myeloid Cells;Myeloid-derived suppressor cells;Natural Immunity;Nature;new therapeutic target;novel;novel marker;novel therapeutics;Pathogenesis;Pathogenicity;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Population;prevent;programs;Proteins;rational design;Regimen;Research Project Grants;response;Role;SARS-CoV-2 immune response;SARS-CoV-2 infection;severe COVID-19;Severities;Severity of illness;single cell analysis;Stains;Surrogate Markers;T cell receptor repertoire sequencing;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;Therapeutic Agents;therapeutic evaluation;Treatment Efficacy;Treatment Protocols;tumor;Variant;Viral Antigens;Virus;Virus Replication;Voltage-Dependent Anion Channel

PROJECT_TITLE: Project 2: Interrogating immuno-metabolic programs using a novel Flow Cytometry based  assay to reveal novel T cell subsets in SARS-CoV-2 infected patients


PROJECT_TERMS: 2019-nCoV;Antibodies;Antibody Response;Antibody titer measurement;antibody-dependent cell cytotoxicity;Autoimmunity;Cells;Characteristics;Clinical;cohort;Complement;Complement Activation;Complement-Dependent Cytotoxicity;convalescent plasma;COVID-19 pandemic;COVID-19 patient;COVID-19 survivors;Data;dimer;Disease;Enrollment;experience;Goals;Hospitalization;Immune response;Immunity;Immunoglobulin A;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin M;Immunoglobulins;Individual;Infection;influenza infection;Kinetics;Linear Regressions;male;Measures;Mediating;Methods;Modeling;monomer;neutralizing antibody;pandemic disease;Pathogenesis;Pathology;Patients;Phase;Plasma;Population;Positioning Attribute;post SARS-CoV-2 infection;Predisposition;prospective;Prospective cohort;Proteins;Public Health;receptor binding;Regression Analysis;Research Personnel;Research Project Grants;Resolution;Resources;response;Role;sample fixation;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 immune response;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Serology;Serology test;Serum;severe COVID-19;Severity of illness;Time;Vaccination;vaccine development;Variant;Virion;virology;Virus;Work

PROJECT_TITLE: Project 3: Defining the antibody landscape after SARS-CoV-2 infection


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PI_NAMEs: BOYD, SCOTT DEXTER (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: 2019-nCoV;Acceleration;Achievement;adaptive immune response;Address;Biometry;Clinical;Collaborations;collaborative environment;Communication;Communities;COVID-19 patient;Data;Data Analyses;data integration;data management;data repository;database of Genotypes and Phenotypes;Disease;Goals;insight;medically underserved population;meetings;member;Mentors;novel diagnostics;novel therapeutics;organizational structure;patient population;Patient-Focused Outcomes;Patients;Populations at Risk;Productivity;Reporting;Research;Research Personnel;Resources;Risk;SARS-CoV-2 immune response;SARS-CoV-2 immunity;SARS-CoV-2 infection;Science;Scientist;Secure;Serology;Structure;Teleconferences;Training;Translations;virology

PROJECT_TITLE: Admin Core


PI_NAMEs: NADEAU, KARI C. (contact)

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Address;Adherence;antibody test;assay development;Basic Science;biobank;Biological Assay;Biopsy;Blood;Budgets;Clinical;clinical care;Clinical Data;clinical implementation;Clinical Management;Clinical Research;Clinical Virology;cohort;Cohort Studies;convalescent plasma;Core Facility;COVID-19;COVID-19 patient;cytokine;Data;Data Analyses;data management;Detection;Development;Disease;Dose;Ensure;experience;Goals;Guidelines;Healthcare;Household;Human;Human Resources;immune checkpoint blockade;Immune response;Immunity;Immunologic Monitoring;Immunologics;Immunology;Immunotherapy;Individual;Infrastructure;innovation;Institutional Review Boards;Laboratories;Leadership;Measures;medically underserved;member;Monitor;novel;Occupational Health;Oncology;participant retention;Patient Care;patient population;Patient Recruitments;Patients;Peptides;Performance;Phenotype;Populations at Risk;preservation;Procedures;Protocols documentation;recruit;research clinical testing;research faculty;Research Project Grants;Reverse Transcriptase Polymerase Chain Reaction;Risk;sample collection;Sampling;SARS-CoV-2 antigen;SARS-CoV-2 immunity;SARS-CoV-2 infection;screening;Services;Specimen;Structure of mucous membrane of nose;success;T-Lymphocyte;Testing;Tissues;Translational Research;Translations;United States National Institutes of Health;vaccine trial;Viral;virology;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Clinical-Virology Core


PI_NAMEs: WANG, TAIA  (contact)

PROJECT_TERMS: 2019-nCoV;Alanine;Amino Acids;Antibodies;Antibody Response;Antibody Specificity;Antigen Targeting;Antigen-Antibody Complex;B-Lymphocytes;Binding;Cell Line;Characteristics;Clinical;clinically significant;Clonal Expansion;Collaborations;COVID-19;COVID-19 pandemic;COVID-19 pathogenesis;COVID-19 patient;COVID-19 treatment;COVID-19 vaccine;Cryoelectron Microscopy;cytokine;Demographic Factors;design;Development;Disease;Dissection;Engineering;Epitope Mapping;Epitopes;Escape Mutant;Evaluation;Genetic;Health;Heterogeneity;Human;Humoral Immunities;IgG Receptors;Immunity;Immunoglobulin-Secreting Cells;Infection;Inflammation;Joints;Kinetics;Life;Maps;Mediating;Membrane Proteins;Memory;Memory B-Lymphocyte;Methods;Molecular;Monoclonal Antibodies;Mucous Membrane;mutant;Mutate;novel vaccines;Outcome;passive antibodies;pathogen;Patients;Persons;Phenotype;Play;Pneumonia;Population;Prevention;Property;Proteins;reconstitution;Research;Research Personnel;Resolution;response;RNA Viruses;Role;Sampling;Sampling Studies;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Serology;seropositive;severe COVID-19;Sorting;Specificity;structural determinants;Structure;Symptoms;T-Lymphocyte;Testing;Therapeutic antibodies;Therapeutic Monoclonal Antibodies;tool;trend;Vaccine Adjuvant;Vaccine Design;vaccine development;vaccine efficacy;vaccine-induced antibodies;Viral Antigens;Viral Proteins;Virion;Virus;Virus Diseases;Work

PROJECT_TITLE: Project 1: Serology


PROJECT_TERMS: 2019-nCoV;Acute;acute COVID-19;Affinity;age stratification;Antibodies;Antibody Response;Antibody Specificity;Antigens;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocyte Subsets;B-Lymphocytes;Bar Codes;Biological Assay;Biopsy;Biopsy Specimen;Blood;Blood specimen;Cell Differentiation process;Cells;Clinical;Clinical Data;Clonal Evolution;Clonal Expansion;Clone Cells;cohort;Collaborations;Communities;COVID-19 severity;Data;Data Analyses;Databases;deep sequencing;design;Disease;Dissociation;DNA;effectiveness evaluation;Epitopes;Ethnic Origin;expectation;follow-up;Frequencies;Funding;immune checkpoint blockade;Immune response;Immunity;Immunofluorescence Microscopy;Immunoglobulin Genes;Immunoglobulin Somatic Hypermutation;Immunoglobulin-Secreting Cells;Immunologic Receptors;improved;Individual;Infection;interest;Joints;Libraries;Light;Link;long term memory;Measures;Memory B-Lymphocyte;Monoclonal Antibodies;monoclonal antibody production;Mucous Membrane;Mutate;neutralizing antibody;Nose;patient response;Patients;peptide based vaccine;peripheral blood;Phenotype;Plasma Cells;Plasmablast;Population;Population Group;prognostic value;Resources;response;Sampling;SARS-CoV-2 exposure;SARS-CoV-2 immunity;SARS-CoV-2 infection;Serology;Serum;sex;Site;Sorting;Specificity;Specimen;Structure of mucous membrane of nose;synergism;T cell response;TFRC gene;Time;transcriptome;Vaccination;vaccine response;Vaccines;Viral Antigens;virology;Virus;Work;Yeasts

PROJECT_TITLE: Project 2: B Cells


PI_NAMEs: DAVIS, MARK MORRIS (contact)

PROJECT_TERMS: 2019-nCoV;Algorithmic Analysis;Alleles;alpha-beta T-Cell Receptor;Antibodies;antigen-specific T cells;Antigens;Automobile Driving;B-Lymphocytes;Biological Assay;Blood;Blood Cells;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Characteristics;Chromatin;Clinical;Clinical Data;Clinical Virology;cohort;Collaborations;Communities;Computational algorithm;COVID-19;COVID-19 patient;cytotoxic;Data;Data Analyses;data integration;Data Set;Databases;design;Disease;early phase clinical trial;Ensure;Epigenetic Process;Epitopes;Female;Gene Expression Profile;Genetic;Genetic Transcription;Genome;genome-wide;genomic tools;Genomics;Goals;high throughput technology;Human;human coronavirus;human leukocyte antigen testing;immune activation;Immunity;Immunologics;improved outcome;Individual;Infection;innovation;interest;Link;Lymphocyte;Measurement;Measures;Modeling;Molecular Analysis;molecular phenotype;Mucous Membrane;next generation sequencing;novel;pandemic disease;Patients;peptide based vaccine;Peptides;Phenotype;post SARS-CoV-2 infection;pre-pandemic;Privatization;Process;programs;Respiratory Mucosa;response;Role;Sampling;SARS-CoV-2 antigen;SARS-CoV-2 immunity;SARS-CoV-2 spike protein;Serology;Sex Bias;Site;Specificity;T cell receptor repertoire sequencing;T cell response;T memory cell;T-Cell Immunologic Specificity;T-Lymphocyte;Technology;Testing;Tissues;tool;transcriptome;transcriptome sequencing;Transposase;Vaccination;vaccination strategy;Vaccines;Variant;Viral;Viral Antigens;Virus;women's outcomes;Work;X Inactivation

PROJECT_TITLE: Project 3: T Cells


PHR: Project Narrative Our highly integrated Center uses novel technologies and reagents to build a portfolio of critical reagents designed to map, track and potentially treat SARS-CoV2 and related infections in the future, while addressing fundamental questions into the molecular and immunologic mechanisms that regulate serologic responses in the mucosal and systemic compartments after natural infection or medical interventions.

PI_NAMEs: BARIC, RALPH S (contact);WOLFGANG, MATTHEW C

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: 2019-nCoV;Address;Antibodies;Antibody Repertoire;Antibody Response;Antigens;Applied Research;Automobile Driving;B-Cell Antigen Receptor;B-Lymphocytes;Basic Science;Biology;Cessation of life;Clinical;cohort;convalescent plasma;COVID-19;COVID-19 treatment;Data;design;Development;Disease;Funding;Future;Goals;Health system;Hospitalization;Human;human monoclonal antibodies;Humoral Immunities;Immune;Immune response;Immunity;Immunoglobulin A;Immunoglobulin G;Immunologics;improved;Individual;Infection;Infrastructure;innate immune function;International;Intervention;Kinetics;Maps;Mediating;Medical;Medical center;Memory;Memory B-Lymphocyte;Molecular;Mucous Membrane;neutralizing antibody;new technology;North Carolina;novel;novel coronavirus;pathogen;Pathogenesis;Pathogenicity;Patient Recruitments;Persons;post SARS-CoV-2 infection;Productivity;programs;Protein Chemistry;Proteins;Reagent;Recombinants;Reporting;Research;Research Project Grants;Resource Sharing;Resources;response;Role;sample collection;Sampling;SARS coronavirus;SARS-CoV-2 antibody;SARS-CoV-2 antigen;SARS-CoV-2 infection;Science;Serology;Serology test;Serum;Services;Techniques;Testing;Texas;Therapeutic Intervention;Time;US State;Vaccines;Virus Diseases;Writing

PROJECT_TITLE: North Carolina Seronet Center for Excellence


PI_NAMEs: BARIC, RALPH S (contact)

PROJECT_TERMS: 2019-nCoV;Address;Agreement;Automobile Driving;Charge;Clinical;cohort;Collaborations;Common Data Element;Community Networks;Consent;COVID-19;Data;data repository;data sharing;design;Dimensions;Disease;Enrollment;Ensure;Experimental Designs;Future;Goals;Grant;Human;Human Resources;Immune response;Infection;Infrastructure;Institutional Review Boards;Knowledge;Laboratories;Leadership;North Carolina;Pathogenesis;Patients;Procedures;programs;Protocols documentation;recruit;Research;Research Infrastructure;Research Project Grants;Resource Sharing;response;Role;sample collection;Sampling;Science;Serology;Services;Structure;Therapeutic Intervention;Vaccination;Virus Diseases

PROJECT_TITLE: Core A: Administrative Core


PI_NAMEs: DESILVA, ARAVINDA M. (contact)

PROJECT_TERMS: 2019-nCoV;Affinity;Antibodies;Antibody Response;Antigens;B-Lymphocytes;Biological Assay;Containment;Coronavirus;Coronavirus spike protein;detection assay;Enzyme-Linked Immunosorbent Assay;Fc Receptor;Goals;Health care facility;human coronavirus;Immune;Immune Sera;Immunoglobulin Genes;Individual;Infection;Label;Length;Mammalian Cell;Measures;Methods;Middle East Respiratory Syndrome;milligram;N-terminal;North Carolina;Nucleocapsid;pandemic disease;Paralysed;Pathogenicity;Pattern;Persons;Production;Property;Proteins;Proteomics;receptor binding;Recombinants;Research;Research Project Grants;Resource Sharing;SARS coronavirus;SARS-CoV-2 antigen;SARS-CoV-2 exposure;SARS-CoV-2 infection;Science;Serology;Serology test;Serum;Site;Sorting;Specificity;Structure;System;Testing;Vaccines;Viral;Viral Pathogenesis;Virus

PROJECT_TITLE: Core B: Shared Resource Core For Characterizing Antibody Responses To SARS-CoV-2 And Other Pathogenic Human Coronaviruses


PI_NAMEs: IPPOLITO, GREGORY C (contact)

PROJECT_TERMS: 2019-nCoV;Abate;Advisory Committees;Affinity Chromatography;Antibodies;Antibody Repertoire;Antibody Response;Area;B cell repertoire;B-Lymphocytes;Binding;Biological Assay;Categories;Cessation of life;Circulation;Clinical Trials;Clonality;Cloning;cohort;comparative;Computerized Medical Record;convalescent plasma;Coronavirus;County;COVID-19;COVID-19 pandemic;cross reactivity;Data;Data Set;Disease;Disease Outbreaks;Enzyme-Linked Immunosorbent Assay;Epitope Mapping;Epitopes;experimental study;Future;Half-Life;Home;Human;human monoclonal antibodies;Immune;Immunoglobulin A;Immunoglobulin G;Immunoglobulins;in vivo;Individual;Infection;Institutional Review Boards;Kinetics;Letters;Masks;Methodology;Middle East Respiratory Syndrome Coronavirus;Molecular;Monitor;Monoclonal Antibodies;mouse model;Mucous Membrane;Natural History;Nature;neutralizing antibody;neutralizing monoclonal antibodies;North Carolina;Outcomes Research;Patients;Pattern;Persons;Phase;Policies;Population;Prevalence;Proteins;Proteomics;Protocols documentation;Research;Resolution;response;Role;sample collection;SARS coronavirus;SARS-CoV-2 spike protein;Scourge;Serology;Serum;social;Source;Specificity;Specimen;Study Subject;Survivors;Swelling;Symptoms;Techniques;Testing;Texas;Time;Transfusion;Translating;US State;Viral;virtual;Virus;Work;zoonotic coronavirus

PROJECT_TITLE: Core C: Immunoglobulin Proteomics in COVID-19


PROJECT_TERMS: 2019-nCoV;Acute Respiratory Distress Syndrome;Address;Antibodies;Antibody Formation;Antibody Repertoire;Antibody Response;Antibody Therapy;Antibody-Dependent Enhancement;Applied Research;Biological Assay;Blood Coagulation Disorders;Cessation of life;China;Chiroptera;clinical care;Clinical Immunology;cohort;Collaborations;Collection;convalescent plasma;Coronavirus;Coronavirus Infections;Country;COVID-19;COVID-19 assay;COVID-19 pandemic;COVID-19 patient;COVID-19 treatment;Data;design;diagnostic assay;Diagnostic Reagent;Disease;Epidemic;Epitopes;Future;future outbreak;Glycoproteins;Goals;Human;human disease;human model;Immune;Immunity;Immunoglobulin A;Immunoglobulin G;Immunology;improved;In Vitro;in vivo;Infection;Inflammatory;insight;Intervention;Investigation;Kinetics;Lentivirus;Maps;Measures;Memory B-Lymphocyte;Middle East Respiratory Syndrome;Middle East Respiratory Syndrome Coronavirus;Modeling;mouse model;Mucosal Immunity;Mucous Membrane;neutralizing antibody;new technology;North Carolina;novel;novel coronavirus;novel diagnostics;old mice;Outcome;pandemic disease;Pathogenicity;Persons;Play;Pneumonia;Population;post SARS-CoV-2 infection;prevent;programs;Public Health;Reagent;Recombinants;response;reverse genetics;Role;Sampling;Sarbecovirus;SARS coronavirus;SARS-CoV-2 exposure;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Serodiagnoses;Serology;Serum;Severe Acute Respiratory Syndrome;Specificity;Study models;Technology;Texas;Therapeutic antibodies;Time;time use;Translational Research;Treatment Protocols;Vaccination;vaccine candidate;Viral;Virus;Work;Zoonoses;zoonotic coronavirus

PROJECT_TITLE: Project 1: Serological Correlates of SARS CoV2 Immunity and Disease


PI_NAMEs: BARTELT, LUTHER A (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Acute;Acute Respiratory Distress Syndrome;Address;Animal Model;Antibodies;Antigen-Antibody Complex;Antigens;Applied Research;attenuation;Automobile Driving;B-Lymphocyte Subsets;Basic Science;Binding;biobank;Biological;Biological Assay;Blood;Blood Coagulation Disorders;Cessation of life;Clinical;cohort;Collaborations;Collection;convalescent plasma;COVID-19;COVID-19 pandemic;COVID-19 pathogenesis;COVID-19 patient;COVID-19 severity;COVID-19 treatment;cytokine;Data;Databases;demographics;Development;Disease;Disease Outbreaks;Drug or chemical Tissue Distribution;Ferritin;Fibrin fragment D;Frequencies;Funding;Hospitalization;Human;Illness Days;Immune;immune activation;Immune response;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunologic Markers;Immunologics;immunoregulation;Individual;Infection;Inflammation;Inflammatory;inflammatory marker;Influenza;Infrastructure;Infusion procedures;innovation;Institution;Interruption;investigator-initiated trial;Kinetics;Libraries;Light;Link;Measures;Memory B-Lymphocyte;metabolomics;Molecular;mortality;mouse model;mucosal site;Mucous Membrane;Mus;neutralizing antibody;North Carolina;novel;Outcome;pandemic pathogen;participant enrollment;Passive Immunotherapy;Patients;Phase;Plasma;plasma cell development;Plasma Cells;Pneumonia;polyclonal antibody;prevent;Property;Proteins;Randomized;receptor binding;Recombinants;Recovery;repository;Research;Research Personnel;Resolution;response;Sampling;SARS coronavirus;SARS-CoV-2 antibody;SARS-CoV-2 antigen;SARS-CoV-2 infection;Serology;Serum;severe COVID-19;Site;Specificity;Specimen;Speed;Syndrome;System;technology development;Testing;Therapeutic;Therapeutic Studies;Tissues;trafficking;translational model;treatment program;Viral;Viral Respiratory Tract Infection;Virus;Virus Replication

PROJECT_TITLE: Project 2: Characterizing humoral responses to SARS-CoV-2, and the immunological and biological effects of plasma therapy for severe Covid-19


PI_NAMEs: WOLFGANG, MATTHEW C (contact)

PROJECT_TERMS: 2019-nCoV;Acute Respiratory Distress Syndrome;Address;Affect;Antibodies;Antibody Repertoire;Applied Research;Automobile Driving;B-Lymphocytes;Bacterial Infections;Basic Science;Cell Physiology;Cells;Cessation of life;Clinical;clinical biomarkers;COVID-19;COVID-19 pathogenesis;COVID-19 patient;COVID-19 severity;Data;Development;Disease;Epithelial Cells;experience;Failure;Hospitalization;Human;Humoral Immunities;Immune;immune function;Immune response;Immune System Diseases;Immunologics;Immunosuppression;improved;indexing;Individual;Infection;Inflammatory;Inflammatory Response;Inhalation;Injury;innate immune function;innate immune mechanisms;Innate Immune Response;Innate Immune System;Interruption;Investigation;Lung;Lung immune response;Macrophage;Mediating;Middle East Respiratory Syndrome;Molecular;Monoclonal Antibodies;mouse model;Mucous Membrane;Natural Immunity;Nature;neutrophil;North Carolina;novel;Outcome;pathogen;Pathogenesis;Pathogenicity;Patients;Peripheral;Pharyngeal structure;Phase;polyclonal antibody;post SARS-CoV-2 infection;Regulation;Repression;Research;Resolution;respiratory;Respiratory Disease;Respiratory distress;response;SARS-CoV-2 infection;Serology;Severe Acute Respiratory Syndrome;Severities;Shapes;Site;Surface;Symptoms;T-Lymphocyte;Testing;Therapeutic;Tissues;Viral

PROJECT_TITLE: Project 3: Serological Interactions with the Mucosal Innate Immune System Regulates COVID-19 Associated Tissue Damage.


ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PI_NAMEs: HIRSCH, FRED R (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: 2019-nCoV;Adherence;Administrator;advocacy organizations;Advocate;Age;anti-cancer research;Antibodies;Antibody Response;Area;Basic Science;Budgets;Cancer Center;Cancer Patient;Caregivers;Clinical;Clinical Research;cohort;Collaborations;Colorado;Communication;Complex;Consult;COVID-19;COVID-19 susceptibility;Data Science Core;data sharing;design;distinguished professor;Doctor of Medicine;Doctor of Philosophy;Ensure;Epidemiology;ethnic diversity;Expenditure;experience;Foundations;Gender;Health system;Hearing;human subject;individual responsibility;Infection;Institution;inter-institutional;Interdisciplinary Study;International;Laboratories;Leadership;Lung;Malignant neoplasm of lung;Malignant neoplasm of thorax;Malignant Neoplasms;Medical;medical schools;meetings;Monitor;National Cancer Advisory Board;National Cancer Institute;Office of Administrative Management;Patient advocacy;Patient Recruitments;Patients;Preparation;Preventive measure;Principal Investigator;professor;programs;Progress Reports;Publications;recruit;Reporting;Research;Research Activity;Research Personnel;Resource Sharing;Resources;SARS-CoV-2 antibody;SARS-CoV-2 infection;Science;Serology;Services;Socioeconomic Status;symposium;synergism;Texas;Thoracic Oncology;timeline;translational cancer research;translational research program;Travel;Universities;Vaccination;Vaccines;vaccinology;virology;Voice;Work

PROJECT_TITLE: Administrative Core


PI_NAMEs: MACK, PHILIP C (contact)

PROJECT_TERMS: 2019-nCoV;Address;Adopted;Advisory Committees;Age;Aliquot;anti-cancer research;Antibodies;Antibody Response;biobank;Biological Assay;Blinded;Blood;Blood specimen;Cancer Control;Cancer Patient;Clinical;Clinical Management;Clinical Research;Clinical Trials;Collection;Colorado;Comprehensive Cancer Center;Control Groups;COVID-19 risk;COVID-19 susceptibility;Data;Data Science Core;Databases;Dedications;design;Development;distinguished professor;Doctor of Philosophy;Elements;Enrollment;Ethnic Origin;experience;Foundations;Gender;Health Insurance Portability and Accountability Act;Human;Individual;Infection;Infrastructure;Institution;Institutional Review Boards;interest;Leadership;low dose computed tomography;Lung;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Medical center;Medical Oncology;Minority;Minority Groups;Mission;Molecular;Monitor;Mutation;Names;operation;Participant;participant enrollment;Pathology;Patient Recruitments;Patients;Pharmaceutical Preparations;Pharmacology Shared Resource;Population Control;Privacy;Process;professor;programs;prospective;protocol development;Publications;recruit;Reporting;Research;Research Personnel;Resources;Role;routine screening;Safety;sample collection;Sampling;SARS-CoV-2 infection;Science;screening program;Serology;Site;Skin Cancer;Smoking History;Southwest Oncology Group;Specimen;System;Thoracic Oncology;Tobacco smoking behavior;translational medicine;Translational Research;translational scientist;Underserved Population;Universities;vaccine-induced antibodies;Vaccines;Work

PROJECT_TITLE: Clinical Core


PI_NAMEs: SHYR, YU  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Animals;Antibodies;Berry;Bioinformatics;Biometry;Clinical;Collaborations;Computer software;COVID-19 susceptibility;Data;Data Analyses;data cleaning;data quality;Data Science Core;Databases;Development;Ensure;Experimental Designs;Human Resources;Informatics;Laboratories;Malignant neoplasm of lung;Manuscripts;member;Methods;Monitor;Participant;Publications;Qi;quality assurance;Quality Control;Reporting;Research;research and development;Research Design;Research Personnel;Research Project Grants;Sample Size;SARS-CoV-2 infection;Science;Serology;Statistical Methods;Testing;translational study;Work;Writing

PROJECT_TITLE: Data Science COre


PI_NAMEs: KRAMMER, FLORIAN  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Advocate;Age;Antibodies;Antibody Response;Binding;Biological Assay;Cancer Control;Cancer Patient;cancer therapy;Cells;Clinical;Clinical Sciences;clinical translation;Clinical Trials;Collaborations;comorbidity;comparative;Complement;Coronavirus;COVID-19;COVID-19 incidence;COVID-19 pandemic;COVID-19 susceptibility;COVID-19 vaccination;COVID-19 vaccine;cytokine;Data Science Core;Death Rate;Demographic Impact;demographics;design;Development;Epithelial Cells;Ethnic Origin;Fc Receptor;Future;Gender;General Population;Generations;Glycoproteins;Hamsters;Histology;Immune;Immune response;Immunity;Incidence;Individual;Infection;infection rate;information gathering;insight;inter-individual variation;Kinetics;Knowledge;Longevity;Lung;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Marketing;Mediating;Modeling;neutralizing antibody;patient response;Patients;Persons;Policies;Population;power analysis;Predisposition;Preparation;prospective;protective efficacy;Race;receptor;Regimen;response;Role;SARS-CoV-2 antibody;SARS-CoV-2 infection;Serology;seropositive;severe COVID-19;Smoking History;Smoking Status;Specimen;Statistical Data Interpretation;Testing;trait;translational scientist;Vaccinated;Vaccination;vaccine candidate;vaccine response;vaccine trial;Vaccines;Viral;Viral Antigens;viral entry inhibitor;Viral Physiology;Viral Proteins;virology;Virus;Vulnerable Populations;Work

PROJECT_TITLE: Project 1: Characterization of the Antibody Response to SARS-CoV-2 in Lung Cancer Patients


PI_NAMEs: GARCIA-SASTRE, ADOLFO  (contact)

PROJECT_TERMS: 2019-nCoV;ACE2;acquired immunity;adaptive immunity;Address;Age;airway epithelium;Anti-viral Agents;Antibodies;antibody-dependent cell cytotoxicity;antiviral immunity;Bioinformatics;Biological Assay;cancer cell;Cancer Patient;Cells;Clinical;Clinical Sciences;Clinical Trials;cohort;Collaborations;Collection;comorbidity;COVID-19;COVID-19 detection;COVID-19 pandemic;COVID-19 risk;COVID-19 susceptibility;COVID-19 treatment;COVID-19 vaccine;cytokine;Data;Data Science Core;Data Set;Death Rate;Defect;demographics;Development;Disease;Emergency Situation;Epithelial Cells;Epithelium;Evaluation;Exhibits;experimental study;Future;gender diversity;Genetic Transcription;Genomic approach;Histology;Human;Immune;Immune response;Immune Sera;Individual;Infection;Influenza A virus;influenzavirus;insight;inter-individual variation;Interferons;Kidney;Knowledge;Lung;lung cancer cell;Lung Diseases;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Methods;Molecular;molecular subtypes;Monitor;Monkeys;mortality;multidisciplinary;Natural Immunity;neoplastic cell;neutralizing antibody;Normal Cell;Normal tissue morphology;novel therapeutic intervention;pandemic influenza;patient population;Patients;permissiveness;Pharmaceutical Preparations;Population;pre-clinical;Predisposition;Preparation;prevent;Prevention strategy;Production;protective efficacy;protein expression;Proteins;receptor;remdesivir;Resistance;Resources;respiratory;respiratory virus;response;Risk;Risk Reduction;Sample Size;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 exposure;SARS-CoV-2 immunity;SARS-CoV-2 infection;screening panel;Serology;severe COVID-19;single-cell RNA sequencing;Smoking;Smoking Status;Specificity;Tissues;Tobacco smoking behavior;transcriptomics;tumor;Vaccination;vaccine distribution;vaccine strategy;Vaccines;Viral;Viral Physiology;Virus Diseases;Virus Receptors;Virus Replication

PROJECT_TITLE: Project 2: Susceptibility of Lung Cancer Cells to SARS- CoV-2 Infection and Antibody-Mediated Neutralization


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative: Not Applicable

PI_NAMEs: SANZ, IGNACIO E. (contact)

PROJECT_TERMS: 2019-nCoV;Accreditation;Address;Administrative Supplement;Advisory Committees;animal safety;assay development;Autoimmunity;B-Lymphocytes;Cancer Center;Cancer Patient;Certification;Conflict of Interest;Dedications;Disclosure;Ensure;experience;Goals;Guidelines;Human;Human Biology;Human Resources;Immune response;Immunology;immunoregulation;Individual;Infrastructure;Institution;Laboratories;Leadership;Malignant Neoplasms;Medicine;meetings;member;multidisciplinary;operation;Pathology;Patients;Physicians;Plasma Cells;Program Evaluation;programs;Protocols documentation;Radiation;recruit;Research Personnel;Research Subjects;Resources;Rotation;Safety;SARS-CoV-2 infection;Scientist;Site;symposium;synergism;System;Training;tumor immunology;Vaccines;Viral Vaccines;Virus Diseases

PROJECT_TITLE: Immune Regulation of COVID-19 Infection in Cancer and Autoimmunity


PHR: Narrative: All of the studies proposed in this U54 Program require blood samples from COVID-19 patient with particular underlying diseases, including systemic lupus erythematosus, rheumatoid arthritis, and multiple myeloma. This Core is in charge of collecting those samples and distributing them to each Project in the most efficient and effective manner possible.

PI_NAMEs: ROBACK, JOHN D (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;acute infection;Address;Administrative Supplement;African American population;Age;Aliquot;Ambulatory Care Facilities;Anemia;Autoimmunity;biobank;Blood;Blood specimen;Cancer Patient;Charge;Clinic;Clinical;clinical investigation;Clinical Investigator;Clinical Research;Collaborations;Collection;Communicable Diseases;Consent;COVID-19;COVID-19 pandemic;COVID-19 patient;data mining;database design;database query;Databases;demographics;design;Disease;Enrollment;Environment;Freezing;Funding;Goals;Healthcare;Hematological Disease;high risk;hospital care;Hospitals;Iatrogenesis;Immunologic Monitoring;immunoregulation;Individual;Institution;Institutional Review Boards;interest;Investigation;Label;Laboratories;Leadership;Location;Malignant neoplasm of lung;Malignant Neoplasms;meetings;Metadata;Multiple Myeloma;Nurses;Oncology;Participant;participant enrollment;Pathologist;patient population;Patient Recruitments;Patients;Peripheral Blood Mononuclear Cell;Plasma;Population;Population Programs;programs;prospective;Publishing;Qualifying;recruit;repository;Research;Research Activity;research clinical testing;Research Personnel;Reverse Transcriptase Polymerase Chain Reaction;Rheumatoid Arthritis;Rheumatology;RNA;sample archive;sample collection;Sampling;Sampling Studies;SARS-CoV-2 infection;SARS-CoV-2 positive;Schedule;Secure;Serology;serosurveillance;Serum;Services;severe COVID-19;Site;Specialist;Specimen;Systemic Lupus Erythematosus;Target Populations;Test Result;Testing;Training;Venipunctures;Venous blood sampling;Whole Blood

PROJECT_TITLE: Core 1:  Sample Procurement and Clinical Core


PHR: Narrative: Requirement in the Overall component only.

PI_NAMEs: NEISH, ANDREW S (contact)

PROJECT_TERMS: 2019-nCoV;Administrative Supplement;Antibodies;Antibody Response;antibody test;antibody-dependent cell cytotoxicity;Autoimmune;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;Binding;Biological Assay;Blood specimen;CLIA certified;Clinical;clinical application;Clinical Immunology;Collaborations;Communicable Diseases;COVID-19 assay;COVID-19 pandemic;COVID-19 patient;design;Detection;detection test;Development;Diagnostic;diagnostic assay;Enzyme-Linked Immunosorbent Assay;Evaluation;FDA Emergency Use Authorization;Funding;Future;Goals;Grant;Healthcare;high throughput analysis;Human;Immune;Immune response;Immunoassay;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunologic Monitoring;Immunologist;immunoregulation;improved;innovation;Laboratories;Laboratory Research;Leadership;Malignant Neoplasms;Measures;Medical;Medicine;meetings;Membrane;Modification;Nucleocapsid;Oncology;pathogenic virus;Pathologist;Pathology;Pathway interactions;patient population;Patients;Physician Executives;Positioning Attribute;Productivity;professor;prospective;Proteins;receptor binding;repository;Reproducibility;Research;research clinical testing;Research Personnel;Resource Sharing;response;Rheumatology;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 antigen;SARS-CoV-2 immune response;SARS-CoV-2 infection;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Serology;Serology test;serosurveillance;Services;Site;Specimen;Testing;Training;Translating;Translational Research;United States National Institutes of Health;Variant;Viral;Viral Respiratory Tract Infection;Viral Vaccines;Virus Diseases;Work

PROJECT_TITLE: Immune Monitoring Core


PHR: Project Narrative Non-Applicable

PROJECT_TERMS: 2019-nCoV;Accounting;Acute;Administrative Supplement;Age;Anti-viral Response;Antibodies;Antibody Repertoire;ATAC-seq;Autoimmune;Autoimmune Diseases;Autoimmunity;autoreactivity;B cell therapy;B-Lymphocytes;Biological Assay;Cancer Patient;Cell Compartmentation;Cell Physiology;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;Clinical;clinical heterogeneity;Clonal Expansion;Collaborations;COVID-19;COVID-19 vaccination;COVID-19 vaccine;Development;Dimensions;Disease;Equilibrium;Ethnic Origin;Event;Fatal Outcome;Flow Cytometry;Generations;Heterogeneity;Human;Immune;immune checkpoint blockade;Immune response;Immune Tolerance;immune-related adverse events;immunodeficiency;Immunoglobulin-Secreting Cells;Immunologic Memory;Immunologics;immunoregulation;Incidence;Individual;Infection;Knowledge;Longevity;Malignant Neoplasms;Measures;Mediating;Memory;Memory B-Lymphocyte;Molecular;Monoclonal Antibodies;Mus;neutralizing antibody;novel;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Phase;Phenotype;Plasma Cells;Population;programs;Regulation;Respiratory Failure;response;SARS-CoV-2 infection;severe COVID-19;Severities;Severity of illness;standard of care;Systemic Lupus Erythematosus;TLR7 gene;transcriptome sequencing;Vaccination;Viral;Work


PHR: Narrative This proposal aims at understanding the mechanistic underpinnings of SARS-COV-2 infection in cancer patients which lead to their worsened prognosis. We will dissect features of the innate and adaptive immune responses using unbiased holistic approaches to define the impact of the cancer host milieu on qualitative and quantitative features of the protective memory T and B cell response. Our major goal is to develop novel effective interventions to treat this severely affected population.

PI_NAMEs: SEKALY, RAFICK PIERRE (contact)

PROJECT_TERMS: 2019-nCoV;acute infection;adaptive immune response;Address;Administrative Supplement;Affect;African American population;Age;Aggressive course;American;Anti-Inflammatory Agents;Antibodies;Antibody Diversity;Antibody Formation;Antigens;Apoptosis;Astronomy;ATAC-seq;Autoimmunity;B-Cell Lymphomas;B-Lymphocyte Subsets;B-Lymphocytes;Bioinformatics;Biological Assay;cancer immunotherapy;Cancer Patient;cancer therapy;cancer type;Cell Compartmentation;Cell Physiology;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;Chromatin;Clinical;Coculture Techniques;cohort;comorbidity;COVID-19;COVID-19 patient;cytokine;Data;Death Rate;density;Disease;Disparity;effective intervention;Effector Cell;Epigenetic Process;epigenome;Ethnic Origin;Flow Cytometry;Functional impairment;Gene Expression Profiling;Genetic Transcription;Goals;high dimensionality;holistic approach;Homeostasis;Immune;Immune response;Immunologic Memory;immunological intervention;immunoregulation;Immunotherapy;Impairment;Incidence;Individual;Infection;Inflammasome;Inflammation;Inflammatory;inflammatory milieu;Innate Immune Response;Interferons;Intervention;Lead;Licensing;Longevity;Lymphopenia;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediating;Medical;Memory;Memory B-Lymphocyte;Metabolic;Methylation;microbial;microbiome;Minor;minority disparity;Modification;Molecular;Monitor;monocyte;mortality;Myeloablative Chemotherapy;Natural Immunity;novel;Obesity;Outcome;Pathway interactions;Patients;Phenotype;Plasmablast;Population;post SARS-CoV-2 infection;Prevalence;Prevention;Process;Prognosis;prophylactic;public health intervention;Radiation therapy;recruit;Regulatory T-Lymphocyte;Reporting;response;SARS-CoV-2 infection;Serum;severe COVID-19;Severity of illness;single-cell RNA sequencing;Societies;Sorting;synergism;T memory cell;T-Lymphocyte;Testing;Therapeutic;transcriptome;transmission process;tumor;Vaccines;Virus;Virus Diseases


PI_NAMEs: DHODAPKAR, MADHAV V (contact)

PROJECT_TERMS: 2019-nCoV;adaptive immunity;Administrative Supplement;African American;Age;American;antiviral immunity;Autoimmunity;B lymphoid malignancy;B-Cell Lymphomas;B-Lymphocytes;Blood;Bone Marrow;Cancer Patient;Caring;Clinical Data;cohort;comorbidity;COVID-19;COVID-19 complications;COVID-19 morbidity;COVID-19 mortality;COVID-19 pandemic;COVID-19 patient;COVID-19 risk;COVID-19 vaccination;COVID-19 vaccine;Data;Development;Disease;Disease Progression;experience;global health;Health;Hematologic Neoplasms;high risk;hypogammaglobulinemia;Immune;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immune system;immune-related adverse events;Immunity;immunodeficiency;Immunologic Memory;Immunologics;Immunology;immunopathology;immunoregulation;Immunosuppression;Immunotherapy;Impairment;Individual;Inflammation;Inflammatory Response;Influenza;insight;Malignant neoplasm of lung;Malignant Neoplasms;Morbidity - disease rate;mortality;multidisciplinary;Multiple Myeloma;Natural Immunity;Non-Small-Cell Lung Carcinoma;Outcome;Paresis;pathogen;Pathology;Patients;Plasma Cell Neoplasm;Plasma Cells;Population;post SARS-CoV-2 infection;Race;Recording of previous events;Regulation;research clinical testing;Research Personnel;response;Risk;SARS-CoV-2 exposure;SARS-CoV-2 immunity;SARS-CoV-2 infection;Seasons;Serology;severe COVID-19;standard care;standard of care;T cell response;targeted treatment;tumor;tumor immunology;Vaccines;Viral;Viral Cancer;Virus;Virus Diseases


PHR: Narrative for Overall: The Emory SeroNet U54 program brings together a multidisciplinary team of scientists to address unmet needs relating to protective immunity against SARS CoV-2 infection. The team has a long track record of studies in viral, tumor- and autoimmunity, and will examine the nature and regulation of SARS-CoV-2 immunity in patients with autoimmunity and cancer. These studies will also provide basic insights into determinants of protective anti-viral immunity and risk of SARS-CoV-2 related immunopathology.

PI_NAMEs: DHODAPKAR, MADHAV V;SANZ, IGNACIO E. (contact)

PROJECT_TERMS: 2019-nCoV;Acute;acute COVID-19;adaptive immune response;Address;Administrative Supplement;African American;Antibody Formation;Antibody Response;Antitumor Response;antiviral immunity;Autoimmune;Autoimmune Diseases;Autoimmunity;B lymphoid malignancy;B-Lymphocytes;Biology;Cancer Patient;cancer therapy;Cells;Clinical;COVID-19;COVID-19 mortality;COVID-19 pathogenesis;COVID-19 severity;COVID-19 vaccination;COVID-19 vaccine;Data Set;Defect;density;Development;Disease;Ensure;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;Equilibrium;experience;Future;Generations;Genetic Transcription;Hematologic Neoplasms;Heterogeneity;high risk;Immune;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunologic Monitoring;Immunologics;Immunology;immunopathology;immunoregulation;Impairment;infection rate;Inflammation;Inflammatory;inflammatory milieu;Innate Immune Response;insight;interest;long term memory;Longevity;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediating;Memory B-Lymphocyte;Minority;Molecular;Monitor;multidisciplinary;Nature;neutralizing antibody;Non-Small-Cell Lung Carcinoma;Outcome;Paresis;pathogenic autoantibodies;Pathogenicity;Pathway interactions;patient population;Patients;Plasma Cells;Population;Population Programs;post SARS-CoV-2 infection;programs;prospective;recruit;Regulation;repository;Research;Research Personnel;response;Risk;Role;Sampling;SARS-CoV-2 immunity;SARS-CoV-2 infection;Scientist;serosurveillance;success;Systemic Lupus Erythematosus;T cell response;T-Lymphocyte;Target Populations;Technology;translational study;tumor;Tumor Antigens;University Hospitals;Vaccines;Viral;Virus;Virus Diseases;Work


ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: NARRATIVE: Overview Our study will be centered on the ethnically/racially diverse population served by our health system in Los Angeles, given then critical need for more knowledge regarding the determinants of COVID-19 related risks in these minority subgroups. Leveraging our collective experience, resources, and infrastructure at major academic institutions from across Southern California (Cedars Sinai, UCSD, UCLA, and USC), we will advance the scientific enterprise through the three distinct yet closely integrated research Projects: Project 1 will elucidate the natural history and longitudinal trajectories that represent the diversity of SARS-CoV-2 exposure, infection, recovery, and clinical immunity patterns across the spectrum of persons at risk; Project 2 will investigate the determinants of SARS-CoV-2 response in persons with altered innate immune function, with a focus on individuals with pre-infection susceptibility traits (e.g. metabolic disease states); and, Project 3 will investigate the determinants of SARS-CoV-2 response in persons with altered adaptive immune function, with a focus on individuals with immune-altered status arising from select malignancies, autoimmune disease, and/or their directed therapies.

PI_NAMEs: FIGUEIREDO, JANE C. (contact);KARIN, MICHAEL ;MERCHANT, AKIL

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: 2019-nCoV;Address;Affect;Area;Autoimmune Diseases;base;Basic Science;biobank;California;Caring;Characteristics;Chronic Disease;Clinical;clinical phenotype;Clinical Sciences;Cohort Studies;Collaborations;Communities;Coronavirus;COVID-19;COVID-19 risk;COVID-19 susceptibility;COVID-19 treatment;Data;Data Analyses;Data Collection;Disease;disorder risk;Enrollment;Ensure;Epidemiologist;Ethnic Origin;Evaluation;Evaluation Studies;experience;Exposure to;Foundations;Funding;Goals;Health;Health Personnel;Health system;Healthcare Systems;Immune;immune function;immune reconstitution;Immunity;Immunologist;Individual;Infection;Inflammatory Response;Infrastructure;innate immune function;insight;Institution;Knowledge;Los Angeles;Malignant Neoplasms;Metabolic Diseases;Minority;Molecular Profiling;Natural History;Nature;novel;operation;Outcome;pandemic disease;Patients;Pattern;Persons;Population Heterogeneity;Population Sciences;Populations at Risk;Predisposition;programs;Public Health;Publishing;racial diversity;racial population;Recovery;Recovery of Function;recruit;Reporting;Request for Applications;Research;Research Personnel;Research Project Grants;Resources;response;Risk;SARS-CoV-2 antibody;SARS-CoV-2 exposure;Scientific Advances and Accomplishments;Scientist;Seroprevalences;severe COVID-19;Signal Transduction;stay-at-home order;Structure;Subgroup;Techniques;Therapeutic;trait;Translational Research;translational scientist;Viral;Virus;Vulnerable Populations;World Health Organization

PROJECT_TITLE: Diversity and Determinants of the Immune-Inflammatory Response to SARS-CoV-2


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Food insecurity affects 13.5 million Americans and is associated with heart disease, diabetes, and poor diet quality. This project uses a community engaged approach to collaborate with food pantries to design, implement, and evaluate digital strategies to encourage pantry clients to choose healthier foods. The goal of the proposed work is to identify acceptable and effective community interventions to improve diet quality and promote cardiovascular health equity among a vulnerable US population.

PI_NAMEs: JIA, JENNY  (contact)

PROGRAM_OFFICER_NAME: ILIAS, MALIHA R

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Affect;American;Architecture;Award;Behavior Therapy;behavioral economics;Belief;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;career;Chicago;Client;Collaborations;Color;Communities;community engaged approach;community intervention;Consumption;cost;Data;Data Collection;Decision Making;design;Diabetes Mellitus;Diet;Dietary Practices;digital;Disparity;Effectiveness;effectiveness study;effectiveness trial;Evaluation;experience;Feedback;Focus Groups;Food;food environment;food insecurity;food security;Food Selections;Future;Goals;Health;Health Benefit;health equity;Health Food;Heart Diseases;high risk;Household;Hybrids;Hypertension;implementation barriers;implementation evaluation;implementation facilitators;implementation research;implementation science;improved;Individual;Inequity;innovation;Interdisciplinary Study;Interruption;Intervention;Intervention Studies;Interview;Knowledge;Label;Low income;Measures;Mentorship;Methods;Modeling;National Heart, Lung, and Blood Institute;new technology;nutrition;Nutrition Labeling;Nutritional;operation;Persons;Population;population health;prevent;prototype;repository;Research;Research Personnel;Research Priority;Resources;Restaurants;Risk Factors;Series;Site;social;social stigma;Strategic vision;System;Testing;therapy design;Time;Training;Training Programs;Training Support;Unhealthy Diet;uptake;Visit;Weight;Work

PROJECT_TITLE: Community-engaged Design and Implementation of a Behavioral Economics Food Choice Intervention in Food Pantries to Improve Cardiovascular Health

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project 3 NARRATIVE Angiogenesis is essential for tumor growth; several anti-angiogenesis drugs including bevacizumab have been approved for clinical use but have shown only modest efficacy. This necessitates development of new anti- angiogenesis therapies. Elevated EGFL6 was reported in ovarian cancer but not in normal adult tissues; our preliminary studies showed that EGFL6 blockade in ovarian cancer models resulted in significant reduction in tumor burden without affecting wound healing. The proposed work could have significant implications for development of new anti-EGFL6 based therapies in ovarian cancer.

PI_NAMEs: SOOD, ANIL K (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Adult;Adverse event;Affect;Aftercare;angiogenesis;Angiogenesis Inhibitors;antiangiogenesis therapy;Antibodies;Antibody-drug conjugates;antitumor effect;Area;bevacizumab;Biological;Biopsy;Blood Vessels;cancer cell;Cancer Model;cancer therapy;Carcinoma;CD4 Positive T Lymphocytes;CD8B1 gene;chemotherapy;Clinical;Collection;Complex;Computer software;Data;Data Analyses;Death Rate;Development;differential expression;Endothelial Cells;Epidermal Growth Factor;Epithelial ovarian cancer;exhaustion;FDA approved;Fibroblasts;first-in-human;Genes;Genetic Transcription;genomic profiling;Growth;Home;Human;humanized antibody;Hypoxia;Immune;Immune checkpoint inhibitor;Immune response;Immunosuppression;improved;in vivo;Infiltration;innovation;insight;Interferons;lead candidate;Macrophage;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Molecular;Monoclonal Antibodies;mouse model;novel;ovarian neoplasm;Ovarian Tissue;Paclitaxel;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;phase 1 study;Phase I Clinical Trials;Physiologic Neovascularization;Plasma;pre-clinical;recruit;Recurrence;Regulation;Reporting;Resistance;response;Role;Safety;Serous;Signal Pathway;Signal Transduction;single cell analysis;Source;T-Lymphocyte;targeted treatment;taxane;Testing;The Cancer Genome Atlas;Therapeutic;therapy outcome;Tissues;tumor;Tumor Angiogenesis;Tumor Burden;tumor growth;tumor microenvironment;tumorigenesis;TWIST1 gene;Uterus;Vascular Endothelial Growth Factors;Work;wound healing

PROJECT_TITLE: Targeting EGFL6 in Ovarian Cancer


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE The Healthy Brain and Child Development (HBCD) study will encompass data collection from a cohort of 7,500 parent-child dyads across 24 independent U01 sites and three additional subcontract sites over a range of modalities including harmonized neuroimaging, neurophysiology, behavioral and cognitive assessments, and the collection of biospecimens. This administrative supplement will enable the HBCD Data Coordinating Center to fully support successful and coordinated data collection and release activities across the Consortium through the accommodation of required and unplanned costs secondary to evolving study workflows and increasing site support needs, opportunities to incorporate new data types into HBCD, changes in federal guidelines related to data sharing, and modality-specific technical requirements for analysis.

PI_NAMEs: DALE, ANDERS M;FAIR, DAMIEN A;SMYSER, CHRISTOPHER DANIEL (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: Acceleration;Administrative Supplement;Affect;Age;awake;Behavior assessment;Behavioral;behavioral health;Biological Factors;Brain;brain health;Child;Child Development;Child Health;Childhood;clinical care;cognitive testing;cohort;Collection;Communities;Computer software;computerized data processing;cost;Data;Data Collection;data collection site;Data Coordinating Center;Data Element;data resource;Data Security;data sharing;Databases;Dedications;Development;Ensure;Environmental Impact;Environmental Risk Factor;Equipment;Family;Feeds;Genetic;Guidelines;Helping to End Addiction Long-term;improved;infancy;Investigation;Leadership;Life;longitudinal dataset;magnetic resonance imaging/electroencephalography;Modality;MRI Scans;multimodality;neurodevelopment;neuroimaging;neurophysiology;Opiate Addiction;Opioid;opioid misuse;Parents;Participant;Pregnant Women;Process;Protocols documentation;Public Health;Public Policy;Quality Control;recruit;Research;Secondary to;Security;Shapes;Site;sociodemographics;Speed;Standardization;Statistical Data Interpretation;success;System;Time;United States National Institutes of Health;usability

PROJECT_TITLE: Healthy Brain and Child Development National Consortium Data Coordinating Center


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Contraception/Reproduction;Disability Research;Intellectual and Developmental Disabilities (IDD);Maternal Health;Pregnancy;Prevention;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE This research project will yield the first large-scale multi-state data on pregnancy-related information needs of women with developmental disabilities that affect cognition (DD-C), and will inform future communication of a range of health messages to people with DD-C. Our proposed decision aid will help women with DD-C assess their support needs in relation to pregnancy, time their pregnancies, prepare for a healthy pregnancy if they decide they are ready for pregnancy, and communicate with medical professionals about reproductive decisions. This project directly supports NICHD's vision of “Healthy pregnancies. Healthy children. Healthy and optimal lives.”

PI_NAMEs: HORNER-JOHNSON, WILLI  (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Adult;adverse outcome;adverse pregnancy outcome;Affect;Child;Choice Behavior;Clinical;Clinical Trials;Cognition;Collaborations;Communication;Comprehension;Conflict (Psychology);Data;Decision Aid;Decision Making;design;Development;Developmental Disabilities;disability;Disadvantaged;efficacy testing;evidence base;experience;Face;financial decision making;Friends;Funding;Future;General Population;Goals;Health;Health behavior;Healthcare;healthy pregnancy;improved;Individual;innovation;Interview;Investigation;Knowledge;Libraries;Low Birth Weight Infant;Mammographic screening;Maternal and Child Health;maternal stress;Medical;Methods;motherhood;National Institute of Child Health and Human Development;Needs Assessment;novel;Operative Surgical Procedures;Outcome;Participant;Patient Participation;Patients;Pattern;peer;Persons;Planned Pregnancy;Population;Pre-Eclampsia;Preconception Care;Pregnancy;Pregnancy Outcome;pregnant;Premature Birth;Preparation;prevent;Process;Readiness;reproductive;Research;Research Project Grants;Resources;Risk;Sampling;Self Efficacy;smoking cessation;sociodemographic group;Subgroup;support tools;Surveys;Target Populations;Time;tool;tool development;Trust;unintended pregnancy;usability;Vision;web based decision aid;web interface;Woman;women with disabilities;women's outcomes;Work

PROJECT_TITLE: Understanding and Supporting Reproductive Decisions Among Women with Developmental Disabilities that Affect Cognition

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PI_NAMEs: KAFTAN, EDWARD  (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Address;AIDS related cancer;Award;Basic Science;cancer care;Cancer Center;Cells;Clinical Research;clinical trial recruitment;Clinical Trials;Communicable Diseases;Communication;Consult;Databases;Development;Development Plans;digital;Direct Costs;Disease;Evaluation;Event;Faculty Recruitment;faculty support;Funding;Goals;Grant;improved;Industry;Infrastructure;innovation;interdisciplinary collaboration;Interdisciplinary Study;Intervention;Journals;Leadership;Malignant Neoplasms;meetings;member;Mission;Nature;Newsletter;operation;Pamphlets;Paper;Patients;Play;Process;process improvement;programs;Publications;Publishing;Radio;Recommendation;Research;research clinical testing;Resource Sharing;Resources;Role;Science;social health determinants;social media;Strategic Planning;symposium;Translational Research;treatment trial;web site;Work;Yale Cancer Center

PROJECT_TITLE: Cancer Center Administration


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Immunization;Microbiome;Pediatric;Pediatric - AIDS;Prevention;Vaccine Related

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: PROJECT NARRATIVE Infants born to HIV-infected mothers have altered immunity and enteric microbiota. However, our understanding of the factors influencing these changes are incomplete. The project utilizes integrative multiomic techniques and gnotobiotic mouse models to characterize the effects of the expanded gut virome of HIV-exposed infants on their bacterial microbiota and responses to vaccination.

PI_NAMEs: BROWN, BRYAN P (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: 16S ribosomal RNA sequencing;adaptive immunity;Adult;Animals;antagonist;Bacille Calmette-Guerin vaccination;Bacteria;bacterial community;Bacterial Vaccines;bacteriome;Bacteriophages;Bayesian Analysis;BCG Live;BCG Vaccine;Biological Assay;Cells;cohort;Colon;Communities;cytokine;Data;data integration;Data Set;Development;Disease;Disease susceptibility;Enteral;Etiology;experimental group;experimental study;Feces;Funding;Gene Expression;Germ-Free;Gnotobiotic;gut bacteria;gut dysbiosis;gut microbiome;gut microbiota;Health;high risk;HIV;HIV Infections;Human;Human Microbiome;Immune;Immune response;Immunity;Immunization;Immunize;Infant;insight;Intestines;Life;Linear Regressions;Link;Mediating;metagenome;Metagenomics;Microbe;microbial;microbiome;microbiota;Modeling;Morbidity - disease rate;Mothers;mouse model;Mucosal Immunity;Mucous Membrane;multiple omics;Neonatal;Peripheral;Play;Probiotics;pup;Research;response;Role;Shapes;Shotguns;single-cell RNA sequencing;Spleen;Statistical Data Interpretation;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Testing;Therapeutic;Vaccination;vaccine response;Viral;Virion;virome;Virus;Whole Blood;Work

PROJECT_TITLE: Identifying inter-kingdom microbial determinants of altered immunity in HIV exposed infants

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: NOTRE DAME

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project Narrative Neighborhood disadvantage (e.g., poverty and exposure to violence) is a robust indicator of youth adjustment difficulties across most domains of development, yet there are youth who thrive despite significant neighborhood adversity. This project investigates: (1) how resilience changes as youth reach important developmental milestones and freely explore their environments, (2) whether these developmental changes differ by resilience domain (psychiatric, social, emotional, academic), and (3) how warm and involved parenting as well as neighborhood protective factors might shape their development. In doing so, the proposed project can identify specific and modifiable protective factors that promote resilience to chronic neighborhood risk.

PI_NAMEs: SHEWARK, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Adolescence;Adolescent Behavior;Adolescent Development;Adult;Area;Award;career;Characteristics;Child;Child Development;Child Rearing;Childhood;Chronic;Church;cognitive ability;cognitive reappraisal;Competence;Data;Development;developmental psychology;early childhood;emerging adulthood;Emotional;Environment;Exclusion;Family;family influence;Goals;Green space;Growth;improved;Informal Social Control;Interdisciplinary Study;intervention program;Knowledge;Lead;life span;Link;Literature;Maintenance;Measurement;Methodology;Methods;middle childhood;Modeling;Nature;neighborhood disadvantage;Neighborhoods;Outcome;Pathway interactions;Personal Satisfaction;Pharmacy facility;Phase;physical conditioning;Play;Populations at Risk;Positioning Attribute;Poverty;promote resilience;protective factors;Research;Research Personnel;resilience;Resources;Risk;Role;Scholars Program;Schools;Science;Shapes;skills;social;social skills;System;Techniques;Testing;Time;Training;Transportation;violence exposure;Work;Youth

PROJECT_TITLE: The Development of Youth Resilience to Neighborhood Disadvantage