NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Heart Disease;Hematology;Nutrition;Physical Activity

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative (Public Health Relevance) Heart failure with preserved ejection fraction (HFpEF) is a highly morbid condition in which exercise capacity is significantly reduced. Our goal is to understand how functional iron deficiency relates to exercise capacity in HFpEF and in middle-aged adults at risk for HFpEF. We will then perform a trial to investigate how iron repletion influences mechanisms of exercise intolerance in patients with symptomatic HFpEF.

PI_NAMEs: LEWIS, GREGORY DYER (contact);MALHOTRA, RAJEEV

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: Activities of Daily Living;Adult;Anemia;Animal Model;Biological Availability;Blood Tests;Blood Vessels;Body System;Cardiac Myocytes;Cardiac Output;cardioprotection;Cardiopulmonary;cardiorespiratory fitness;Cardiovascular Diseases;Cardiovascular system;Catecholamines;Cell Respiration;Cells;Citric Acid Cycle;cohort;Communities;cost;Development;EFRAC;Enzymes;Erythropoiesis;Exercise;exercise capacity;exercise intolerance;Exercise Test;Ferritin;Framingham Heart Study;Functional disorder;General Population;Generations;Genetic Determinism;Goals;Guidelines;Heart failure;hemodynamics;Hemoglobin concentration result;hepcidin;HFE2 gene;High Prevalence;Homeostasis;Hormones;Human;Impairment;improved;Individual;Inflammatory;insight;Interleukin-1 beta;Interleukin-6;Intervention;Intravenous;Iron;iron deficiency;iron supplementation;Liver;Measures;middle age;Morbidity - disease rate;mortality;Muscle Fibers;Myoglobin;Nitric Oxide;Oral;Organ;Oxidative Phosphorylation;Oxygen;Patients;Peripheral;Pharmacotherapy;Phenotype;Physiological;Play;Population;pregnant;preservation;Prevalence;Production;prospective;Proteins;Public Health;public health relevance;Pulmonary Vascular Resistance;Quality of life;randomized trial;Recommendation;Reporting;Risk;Risk Factors;Role;routine screening;Serum;Signal Pathway;Skeletal Muscle;Study models;Therapeutic;Transferrin;United States National Institutes of Health;ventricular hypertrophy;Work

PROJECT_TITLE: Characterization of Functional Iron Deficiency and Repletion in Heart Failure with Preserved Ejection Fraction

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Hematology;Infectious Diseases;Neurosciences;Prescription Drug Misuse;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Persistent HIV replication in populations of macrophages and microglia in protected anatomical compartments like the brain is a central impediment to successfully curing HIV. This problem is heightened among vulnerable populations with substance use disorders, including misuse of therapeutics such as benzodiazepines which exacerbate neuroHIV. This proposal will address these issues by defining the transcriptional processes regulating HIV replication dynamics in myeloid cells and evaluating how epigenetic factors such as RUNX1 are involved in benzodiazepine mediated increases in transcription and replication.

PI_NAMEs: GASKILL, PETER JESSE (contact);KLASE, ZACHARY ALAN

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: abuse liability;Affect;American;Anatomy;antiretroviral therapy;Atlases;Awareness;benzodiazepine misuse;Benzodiazepines;Blood Vessels;Brain;cell type;Cells;Central Nervous System;Chromatin;chromatin immunoprecipitation;chronic infection;Clinical;Complex;Data;Data Correlations;Development;Disease;DNA;Dose;drug misuse;Epigenetic Process;epigenetic regulation;Failure;gag Gene Products;Gene Expression Profile;Genetic;Genetic Transcription;HIV;HIV Infections;HIV-1;Human;human induced pluripotent stem cells;Image;Individual;induced pluripotent stem cell;Infection;Infection prevention;knock-down;Macrophage;Mediating;memory CD4 T lymphocyte;Microglia;monocyte;mutant;Myelogenous;Myeloid Cells;neuroAIDS;Neurocognitive;neuroinflammation;Neuropathogenesis;novel therapeutics;Outcome;Penetrance;Persons;Pharmaceutical Preparations;Population;Process;Production;programs;Protocols documentation;Proviruses;Publishing;reactivation from latency;Recrudescences;recruit;reduce symptoms;Regulation;Risk;Role;RUNX1 gene;single cell ATAC-seq;single-cell RNA sequencing;Small Interfering RNA;Source;Substance Use Disorder;Symptoms;Testing;Therapeutic;Transcription Process;Transcriptional Regulation;Viral;viral DNA;Viral reservoir;viral RNA;Virion;Virus;Virus Replication;Vulnerable Populations;Xanax

PROJECT_TITLE: Benzodiazepine mediated mechanisms of transcriptional semi-quiescence in discrete myeloid populations


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: DURHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE Less than 2% of the human genome sequences are protein-coding genes, while more than 98% of the genome consists of non-coding regulatory DNA and RNA sequences which play an essential role in biology and human diseases. Targeted engineering the function and activity of non-coding regulatory genome could greatly expand the “druggable genome”, and holds great promise for gene-regulation based therapeutics and genomics medicine. Here, by taking advantage of our newly developed multi-omics approach, we seed to identify the regulators, which determine the activity of non-coding DNA and RNA sequences and can be utilized to modulating gene expression via engineering non-coding regulatory sequences.

PI_NAMEs: DIAO, YARUI  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Amino Acid Sequence;Biochemical;Biological Process;Biology;Cells;Chromatin;Code;Development;Disease;disease model;DNA Sequence;Engineering;Enhancers;Epigenetic Process;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Genomic DNA;Genomic medicine;Genomics;Goals;human disease;Human Genome;in vivo Model;innovation;Knowledge;Mediating;Modification;Molecular Analysis;mouse model;multiple omics;novel strategies;Play;Proteins;recruit;Regulation;Research;RNA;RNA Sequences;Role;Testing;Therapeutic;Untranslated RNA;Work

PROJECT_TITLE: Multi-omics functional analysis of non-coding regulatory genome for genomic medicine


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Health Services;Palliative Care;Patient Safety

ORG_CITY: BOSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: NARRATIVE Patients who survive acute critical illness but require prolonged mechanical ventilation (PMV, i.e. mechanical ventilation >14-21 days) are growing rapidly in number, have large post-acute care expenditures, and experience a grim 60% 1-year mortality. It is unclear how decisions made during the transition from acute respiratory failure to prolonged mechanical ventilation (e.g. use of LTCHs for post-acute care) impacts long- term outcomes. We will determine (1) trends and drivers of variation in post-acute facility use among patients at high risk for PMV and (2) the ways in which LTCH use may influence provider behavior at short stay hospitals and outcomes of patients at high risk for PMV, using quantitative/econometric and qualitative methods. The knowledge generated from this mixed methods approach will be critical to inform both clinical practice (i.e. by altering the way providers plan for and choose optimal sites of post-acute care) and future policy (i.e. by potentially shaping future payment reform and determining whether other sites of post-acute care, such as skilled nursing facilities, should be targets of quality reporting legislation).

PI_NAMEs: LAW, ANICA C (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute;acute care;Acute respiratory failure;Admission activity;advanced directive;Affect;care outcomes;career;Caregivers;Caring;Case Manager;clinical practice;cohort;cost;Critical Illness;Data;Decision Making;Dedications;Do Not Resuscitate Order;econometrics;Enteral Feeding;Expenditure;experience;Family;Future;Gastrostomy;Goals;Health Services;high risk;Home;hospital bed;hospital care;Hospital Closures;Hospitalization;Hospitals;improved;improved outcome;informant;Institution;Intervention;Interview;Knowledge;large-scale database;Learning;Length of Stay;Life;Mechanical ventilation;Medicare;meetings;Mentorship;Methods;Modeling;mortality;multidisciplinary;Natural experiment;novel;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Pattern;payment;Physicians;Policies;prognostication;Provider;provider behavior;Qualitative Methods;Reporting;Research Personnel;Shapes;Site;Skilled Nursing Facilities;Statutes and Laws;Structure;Testing;Time;Tracheostomy procedure;trend;Tube;Uncertainty;United States National Institutes of Health;Variant

PROJECT_TITLE: Prolonged mechanical ventilation: patterns of post-acute care and patient outcomes

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Nutrition;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Sarcopenia

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Sarcopenia, defined as low muscle mass and function, affects up to 60% of individuals diagnosed with colorectal cancer and is associated with treatment complications, poor prognosis, and reduced overall and cancer-related survival. Currently, there have been no investigations into therapeutic strategies to ameliorate the burden of sarcopenia in cancer. The goal of this proposed study is to examine the feasibility and acceptability of creatine supplementation and resistance training in individuals who are sarcopenic after treatment for colorectal cancer and to measure outcomes related to body composition, physical function and quality of life.

PI_NAMEs: FAIRMAN, CIARAN  (contact)

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Adherence;Adverse event;Affect;Aftercare;Aging;arm;Biology;Body Composition;Body fat;Bone Mineral Contents;cancer care;cancer diagnosis;Cancer Survivor;cancer therapy;Characteristics;chemotherapy;Clinical;colon cancer patients;Colorectal Cancer;colorectal cancer treatment;cost estimate;Creatine;Data;density;design;Diagnosis;Dietary Intervention;dietary supplements;disability;Economic Burden;Effectiveness;Etiology;Exercise;exercise intervention;exercise training;experience;Future;Goals;Health;health related quality of life;Healthcare Systems;Hospital Costs;Individual;Inflammation;innovation;insight;Intervention;intervention effect;Investigation;lifestyle intervention;Malignant Neoplasms;Malnutrition;Measures;men;Mitochondria;mitochondrial dysfunction;Molecular;Morbidity - disease rate;mortality;multimodality;Muscle;Muscle Cells;muscle form;Muscle function;muscle strength;Natural Compound;novel;Nutritional Study;older adult;Outcome;Outcome Measure;Physical Function;physical inactivity;pilot trial;Placebos;Play;Population;Prognosis;prognostic;protein degradation;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;recruit;reduced muscle mass;Reporting;Research Priority;resistance exercise;response;Role;Safety;Sampling;sarcopenia;secondary outcome;side effect;Signal Transduction;skeletal muscle wasting;success;Supplementation;Testing;Therapeutic;Thinness;Treatment-related toxicity;trial comparing;Tumor Burden;Woman

PROJECT_TITLE: The Feasibility and Acceptability of Resistance Training and Creatine Supplementation to Promote Physical Function in Sarcopenic Colorectal Cancer Survivors

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: As preclinical Alzheimer's Disease (AD) becomes a more common target of intervention studies, there is an increased demand for cognitive assessments that are sensitive to very early cognitive change. This study will develop the mobile Cognitive App Performance Platform (mCAPP), with tasks based on current theories of cognitive neuroscience and focused on areas of domain-specific cognitive deficits known to be impacted early in AD. The mCAPP will be validated in a cohort of carefully characterized individuals with neuropsychological and neuroimaging biomarker data in order to leverage existing data and create a tool that has the potential to reduce study participation burden, gamify the experience to increase engagement, and provide an opportunity to collect cognitive data frequently and quickly for the purpose of cognitive screening and monitoring cognitive change during intervention trials in preclinical AD.

PI_NAMEs: MECHANIC-HAMILTON, DAWN J (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Aging;aging brain;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Area;Assessment tool;Atrophic;Biological Markers;career;career development;Caring;Clinic;Code;Cognition;Cognitive;cognitive change;Cognitive deficits;cognitive neuroscience;cognitive performance;cognitive testing;cohort;computerized;Data;Data Collection;Data Set;design;Detection;Development;Diagnosis;digital technology;Early Diagnosis;Enrollment;entorhinal cortex;Environment;executive function;experience;flexibility;Floor;Funding;Health;Hippocampus;Home;Impaired cognition;Individual;Intervention;Intervention Studies;Intervention Trial;Knowledge;Lead;Length;Magnetic Resonance Imaging;Measures;medial temporal lobe;Memory;mobile computing;Molecular;molecular pathology;Monitor;Motivation;Nerve Degeneration;Neuroanatomy;Neurobehavioral Manifestations;neuroimaging marker;Neuropsychology;older adult;Pattern;Performance;Phosphorus 32;pilot test;Positron-Emission Tomography;pre-clinical;Principal Investigator;processing speed;Property;Psychometrics;remote administration;Reporting;Research;Resolution;Resources;response;Risk;screening;structural imaging;targeted imaging;Temporal Lobe;Testing;theories;Time;tool;treatment trial;United States National Institutes of Health;Update;user-friendly;Validation

PROJECT_TITLE: Development of a Mobile Cognitive App for Detecting and Monitoring Change in Preclinical Alzheimer's Disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Contraception/Reproduction;Endometriosis;Pain Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: PATHOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Endometriosis is a common and debilitating gynecological disease affecting ~10% of women ages 15-45. Our studies investigating endometrial regeneration in endometriosis will address the goals of the NICHD related to the investigation of stem cells in the endometrium and to development of therapies for gynecologic disorders.

PI_NAMEs: MONSIVAIS, DIANA  (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: 3-Dimensional;ACVR1 gene;Adult;Affect;Age;aldehyde dehydrogenases;Anabolism;Area;Bioinformatics;Biological Assay;bone morphogenetic protein receptors;Bone Morphogenetic Proteins;cancer stem cell;Cell Differentiation process;Cell Separation;cell type;Cells;Choristoma;chronic pelvic pain;Clinical;cohort;Collaborations;college;Data;Defect;Development;Diagnosis;Differentiation Antigens;Disease;drug discovery;Drug Targeting;efficacy evaluation;efficacy testing;Endometrial;endometrial organoid;Endometriomas;endometriosis;Endometrium;Enzymes;Epithelial Cells;Epithelium;Excision;experience;Family;Female Genital Diseases;Fibrosis;Floods;Gene Expression Profile;Genetic;genome-wide;Gland;Goals;Greater sac of peritoneum;Growth;Gynecologic;Health;hormone therapy;Hormones;Human;Image;In Vitro;in vivo;Infertility;Inflammation;inhibitor;Intestines;Investigation;kinase inhibitor;Knowledge;Lead;Lesion;life span;Ligands;Medicine;member;Metabolism;Morphology;mouse model;Mus;National Institute of Child Health and Human Development;Natural regeneration;neglect;Non-Steroidal Anti-Inflammatory Agents;novel;Operative Surgical Procedures;Organ;Organoids;Ovarian;Ovary;overexpression;Pain;Pain management;Pathway interactions;Patients;Pelvic Pain;Peritoneal;Phosphotransferases;Play;Postpartum Period;Pregnancy;progenitor;Proliferating;Psyche structure;Publishing;receptor;Recurrence;regeneration potential;regenerative;repaired;Reporter;response;Retinoids;Role;Self Assessment;self-renewal;side effect;Signal Pathway;Signal Transduction;Signaling Protein;small molecule inhibitor;Social Well-Being;stem cell biomarkers;stem cell division;stem cell function;stem cell niche;stem cell self renewal;stem cells;stemness;Stromal Cells;System;Testing;Therapeutic;therapeutic target;therapeutically effective;therapy development;Tissues;transcriptomics;Transforming Growth Factor beta;Transforming Growth Factors;Tretinoin;Uterine cavity;Woman

PROJECT_TITLE: Targeting the endometrial stem cell niche inendometriosis

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative The intracellular bacterial pathogen Legionella pneumophila is an important cause of hospital- and community- acquired pneumonia. We propose to define novel mechanisms underlying how the innate immune system successfully overcomes the ability of Legionella to disarm alveolar macrophage function. Defining these mechanisms will enable the design of new anti-bacterial therapeutics that are effective against Legionella and other intracellular bacterial pathogens.

PI_NAMEs: SHIN, SUNNY  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Ablation;Acetyl Coenzyme A;Address;aerobic glycolysis;alveolar epithelium;Alveolar Macrophages;Anti-Bacterial Agents;Antibiotic Resistance;antimicrobial;Automobile Driving;Bacterial Infections;Bacterial Pneumonia;Cell Physiology;cell type;Cells;Collaborations;Communities;community acquired pneumonia;cytokine;Cytokine Signaling;Data;Defense Mechanisms;defined contribution;design;Development;Enzymes;epigenetic marker;Epigenetic Process;Epithelial Cells;Funding;Future;Generations;Genetic Transcription;Granulocyte-Macrophage Colony-Stimulating Factor;Granulocyte-Macrophage Colony-Stimulating Factor Receptors;Histone Acetylation;Hospitals;Host Defense;Host Defense Mechanism;Immune;immune clearance;improved;In Vitro;in vivo;Infection;Infection Control;Inflammatory;Inflammatory Response;innate immune mechanisms;Innate Immune System;insight;Interleukin-1;Interleukin-1 alpha;Interleukin-1 beta;Interleukin-1 Receptors;Interleukin-12;Interleukin-6;JAK2 gene;Knowledge;Lactate Dehydrogenase;Legionella;Legionella pneumophila;Legionnaires' Disease;Licensing;Lung;Mediating;Metabolic;monocyte;Morbidity - disease rate;mortality;mouse model;Myeloid Cells;Nosocomial pneumonia;novel;pathogen;pathogenic bacteria;pathogenic microbe;Production;programs;Protein Biosynthesis;Publishing;Receptor Signaling;Research;response;Role;Signal Transduction;Source;Stat5 protein;Testing;Therapeutic;therapeutically effective;Time;TNF gene;Transcriptional Activation;Translations;Type IV Secretion System Pathway;Vaccines;Virulence;Virulence Factors

PROJECT_TITLE: Innate immune-mediated control of pulmonary Legionella pneumophila infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-S(02)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: COLLEGE PARK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Narrative By harmonizing and freely disseminating current and historical time diary data from around the world, IPUMS Time Use enables rigorous and reproducible investigations of the implications of time use for health and well- being over time and space and among population subgroups. The data are critical for understanding the uneven consequences of public health crises (e.g., the COVID-19 pandemic, structural racism) and social determinants of children’s formative experiences, family processes, parenting, and quality of life. The expansions and enhancements proposed in this continuation will stimulate scientifically rigorous, policy-relevant research on population behavior, health, and well-being across the life course, over time, and across policy contexts.

PI_NAMEs: FLOOD, SARAH M;SAYER, LIANA C (contact)

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Affect;Age;aged;American;application programming interface;Area;Asia;base;Behavior;behavior measurement;Belgium;career;Child;Child Rearing;cloud based;Code;Communities;Complex;cost;Country;COVID-19 pandemic;Data;data acquisition;data harmonization;data infrastructure;Data Set;Databases;diaries;Dimensions;Discipline;Documentation;Eating;Economics;Education and Outreach;Ensure;Europe;experience;Family Process;flexibility;Funding;Gender Role;Geography;Health;health data;health inequalities;Hour;improved;Income;Individual;Industry;Infrastructure;innovation;interactive tool;International;Interview;Investigation;Investments;Life Cycle Stages;Measures;Metadata;Mission;Names;National Institute of Child Health and Human Development;New York;North America;Obesity;Occupations;outreach;Personal Satisfaction;Persons;Phase;Physical activity;Policies;Population;Population Dynamics;population health;population survey;preservation;Public Health;Quality of life;racial minority;Reproducibility;reproductive;Research;Research Personnel;Research Support;Resources;Respondent;Sampling;Scheme;sedentary lifestyle;Services;Sleep;sleep quality;social;social determinants;Source;Structural Racism;Structure;Students;Subgroup;Surveys;Time;time use;Training;Training Activity;trend;user-friendly;Variant;Woman;Work

PROJECT_TITLE: Time Use Data for Health and Well-Being

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: The reactivation of Plasmodium vivax dormant parasites is one of the major challenges to current malaria elimination efforts. We propose to implement a tightly-controlled field study in Cambodia, specifically designed to empower state-of-the-art genomic analyses, to rigorously study P. vivax relapses and the efficacy of primaquine radical cure. Our studies will provide a unique perspective on the mechanisms regulating these dormant parasites and will provide immediately-relevant clinical information to better eliminate this important human parasite.

PI_NAMEs: SERRE, DAVID  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Address;Adherence;Africa;Alleles;Area;atovaquone;Biology;Blood;Blood specimen;Cambodia;Chloroguanide;clinically relevant;Collaborations;Collection;Country;CYP2D6 gene;design;Detection;Development;Dose;Drug Kinetics;economic impact;efficacy evaluation;empowerment;Enrollment;Erythropoiesis;Falciparum Malaria;field study;Fingers;Frequencies;Gene Expression;Gene Expression Profile;Genes;Genetic Polymorphism;Genome;genome sequencing;Genomic approach;Genomics;Genotype;Glucosephosphate Dehydrogenase Deficiency;Human;improved;In Vitro;Incidence;Individual;Infection;Inflammation;insight;Laboratories;Liver;Malaria;Metabolism;Modernization;Morbidity - disease rate;Parasites;patient subsets;Patients;Pattern;Persons;Pharmaceutical Preparations;Plasmodium falciparum;Plasmodium vivax;Population;Predisposition;Primaquine;Primary Infection;Proteins;Proxy;Recommendation;Recrudescences;Recurrence;Regimen;Relapse;response;Retreatment;Sepsis;Serology;side effect;Sporozoites;Testing;Time;transmission process;Variant;Vivax Malaria;whole genome;Work

PROJECT_TITLE: Rigorous Assessment of P. vivax Relapses and Primaquine Efficacy for Radical Cure

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Aging;Chronic Obstructive Pulmonary Disease;Emphysema;Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: Aging is associated with loss of lung structure, declining function, and increased susceptibility to lung disease, together termed senile emphysema. The goal of this proposal is to define mechanisms that result in loss of adult mesenchymal vascular progenitor and innate lymphoid progenitor cell function, contributing to accelerated lung aging and increased susceptibility to emphysema in the aged population.

PI_NAMEs: MAJKA, SUSAN M (contact);REINHARDT, RICHARD LEE

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: 5 year old;Acceleration;Address;Adult;Age;age acceleration;age related decline;aged;Aging;aging population;angiogenesis;Biological Assay;Biology;Blood Vessels;Cardiovascular system;Cell Communication;Cell Count;Cell Physiology;Cells;Cellular Structures;Characteristics;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Coculture Techniques;Coupled;cytokine;Data;Development;Disease;Distal;Endothelium;epithelial stem cell;exhaustion;exposure to cigarette smoke;Female;Functional disorder;Goals;Histologic;Homeostasis;Human;human model;Immune;immune cell infiltrate;Impairment;In Vitro;in vivo;in vivo evaluation;Inflammation;Inflammatory;Inflammatory Infiltrate;Interleukin-13;knock-down;Knowledge;Link;Lung;Lung Diseases;Lung Lavage Fluid;Lymphoid;Lymphoid Cell;Maintenance;male;Medial;Mesenchymal;Modeling;mouse model;Mus;novel;old mice;Oxidation-Reduction;Patients;Phenotype;Physiological;Physiology;Plasma;Play;Predisposition;Premature aging syndrome;Process;progenitor;Prognosis;Proteins;Pulmonary Emphysema;pulmonary function;Sampling;Senility;single-cell RNA sequencing;Smoker;Smoking;spheroids;stem cell aging;stem cell function;stem cell population;stem cells;Stromal Cells;Structure;Structure of parenchyma of lung;Subgroup;Testing;Tissues;transcriptomics;Vascular Diseases;Vascular remodeling;Work

PROJECT_TITLE: Loss of progenitor function accelerates lung aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-A(03)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

PHR: PROJECT NARRATIVE  Despite accumulating evidence indicates that alpha-synuclein-based neurodegeneration develops first in the brainstem before affecting other brain areas, existing imaging methods are incapable of resolving details of tiny deep brainstem nuclei in living elderly humans. This limits our capability of diagnosing and treating early stage synucleinopathy patients (such as premotor Parkinson's disease) before they develop symptoms. The goal of this project is to fill this gap by generating an atlas of arousal and motor brainstem nuclei in living elderly healthy subjects by ultra-high field MRI. We will use the atlas as a tool to investigate brainstem-based biomarkers of premanifest synucleinopathy able to assess the integrity of brainstem microstructure and connectivity pathways before the development of full-blown neurodegeneration.

PI_NAMEs: BIANCIARDI, MARTA  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Adult;Affect;Aging;alpha synuclein;Alzheimer's Disease;Animal Model;Animals;Area;Arousal;Atlases;Behavioral;Behavioral Symptoms;Biological Markers;biomarker identification;biomarker validation;Brain;Brain region;Brain Stem;Cell Nucleus;Clinical;Clinical Research;comparison control;Complex;connectome;Corpus striatum structure;Dementia;Dementia with Lewy Bodies;Dependence;Development;Diagnosis;Diagnostic;diagnostic biomarker;disability;Disease;Disease Progression;dorsal motor nucleus;Early Diagnosis;Early treatment;Elderly;Evaluation;Fostering;Goals;Human;human model;Image;imaging biomarker;imaging modality;Imaging Techniques;Impaired cognition;Impairment;improved;in vivo;Individual;Lewy Bodies;Lewy Body Dementia;Location;locus ceruleus structure;Magnetic Resonance Imaging;Maps;Methods;Modeling;Morphology;Motor;Multiple System Atrophy;Neocortex;Nerve;Nerve Degeneration;Neurobehavioral Manifestations;Neurodegenerative Disorders;neuroimaging;novel;novel diagnostics;Older Population;olfactory bulb;Outcome;Parkinson Disease;Parkinson's Dementia;pars compacta;Pathogenesis;Pathway interactions;Patients;Physicians;Population;prevent;protein aggregation;Proteins;raphe nuclei;REM Sleep Behavior Disorder;Research;research study;Resolution;Reticular Formation;Risk;Role;Structure;Substantia nigra structure;Symptoms;synucleinopathy;Technology;Testing;Therapeutic;therapeutic development;Time;tool;Work;young adult

PROJECT_TITLE: Brainstem-based imaging biomarkers of premanifest synucleinopathy

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Genetics;Hearing Loss

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Hearing loss is the most common sensory deficit in humans and causes severe disability in affected individuals. The goal of this project is to understand how sensory cells within the ear build a mechano-sensitive hair bundle to detect sound, as this process is commonly disrupted in genetic and acquired forms of hearing loss. We propose to study the molecules that build and maintain the hair bundle, and to understand how disruption to these processes cause hearing loss.

PI_NAMEs: BIRD, JONATHAN EDWARD (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Acceleration;Actins;Affect;Animals;Architecture;ATP phosphohydrolase;ATPase Domain;Auditory;Binding;Biochemical;Biological Assay;C-terminal;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Cochlea;Complex;Critical Pathways;Cryoelectron Microscopy;Cytoskeleton;Data;deafness;Defect;Detection;Development;disability;Ear;Electron Microscopy;Epidermal Growth Factor Receptor Pathway Substrate 8;experimental study;Filament;Fluorescence Microscopy;Foundations;Genes;Genetic;Genetic Engineering;GNAI3 gene;Goals;GPSM2 gene;Growth;Hair;Hair Cells;Hearing;hearing impairment;Heart;Height;hereditary hearing loss;Human;In Vitro;in vitro activity;in vivo;Individual;Inherited;Laboratories;Labyrinth;Life;Life Cycle Stages;light microscopy;Longevity;Maintenance;Measures;Mechanics;mechanotransduction;Microfilaments;Microscopy;Molecular;Molecular Motors;monomer;Motor;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Myosin ATPase;N-terminal;novel;Organelles;Outcome;particle;Pathologic;Pathology;Pathway interactions;Patients;Phase;polymerization;Polymers;postnatal;preservation;Process;Property;protein complex;Protein Isoforms;protein purification;Proteins;Pyrenes;Resolution;Sensory;single molecule;sound;Spectrum Analysis;Stereocilium;Structure;synergism;Tail;Testing;trafficking;WHRN gene;Work

PROJECT_TITLE: Molecular Mechanisms of Hair Bundle Development and Maintenance


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Data Science

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: BIDS-TP: Project Narrative The focus of the University of Michigan (UM) Biomedical Informatics and Data Science Training Program (BIDS-TP) is on developing a unique environment and an effective curriculum to train a cadre of data-savvy, computationally-skilled, and highly-motivated biomedical scholars. All BIDS-TP students will be trained in collecting, managing, processing, interrogating, and analyzing large amounts of complex high-dimensional biomedical information, as well as scientific rigor, validity, and reproducibility. BIDS-TP will increase the capacity, ability, and efficacy of the US workforce to address known and unexpected biomedical, health and environmental challenges using advanced bioinformatics and data science techniques.

PI_NAMEs: DINOV, IVO D (contact);MILLS, RYAN E

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: biomedical informatics;Data Science;Training Programs

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative About 30 million Americans have diabetes, another 84 million have prediabetes, and nearly a quarter of health care expenditures are for diabetes and its complications. In addition to economic costs, metabolic diseases like diabetes cause enormous suffering due to heart disease, kidney failure, liver failure, strokes, amputations and many other health problems. This application is relevant to public health because of its overarching goal of training exceptional scientists capable of developing new strategies to decrease the burden of diabetes in the United States.

PI_NAMEs: COLONNA, MARCO ;SEMENKOVICH, CLAY F. (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Diabetes Mellitus;Metabolic Diseases

PROJECT_TITLE: Diabetes and Related Metabolic Diseases

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Lung;Lung Cancer;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: Project Narrative: Several prior studies have shown the potential value of medication sampling to promote population-wide smoking cessation engagement, but whether these same benefits apply to varenicline, arguably the best single-agent cessation medication, is unclear. This randomized clinical trial will offer a test of varenicline sampling as a method to engage all smokers in the quitting process. Ultimately, the population impact of medication/varenicline sampling could be profound, offering a significant and measurable opportunity to lessen the impact of tobacco on public health.

PI_NAMEs: CARPENTER, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: CICCOLO, JOSEPH THOMAS

PROJECT_TERMS: Address;Agonist;antagonist;Archives;Attitude;Behavior;Behavioral;Biochemical;Biological;brief advice;Cancer Control;cancer prevention;catalyst;Clinic;Clinical;clinically significant;comparison group;Cues;Data;design;diaries;Dose;Drug Prescriptions;evidence base;Exercise;Face;Failure;Fatigue;follow-up;Future;Goals;Guidelines;Hand;Health Personnel;Health Technology;Incidence;innovation;Instruction;Internal Medicine;Intervention;Malignant Neoplasms;Measurable;Mediator;Medical;Methodology;Methods;mHealth;mindfulness;Morbidity - disease rate;mortality;Motivation;nicotine replacement;optimism;Outcome;Participant;Penetrance;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Physicians;Population;population based;pragmatic intervention;Prevention Research;primary care setting;Procedures;Process;programs;psychologic;Public Health;Publications;quitline;Randomized;randomized, clinical trials;Reaction;Recommendation;recruit;Research;Resources;Risk Factors;Risk Reduction;Role;Safety;Sampling;Sampling Studies;secondary outcome;Self Efficacy;side effect;Smoker;Smoking;Smoking Behavior;smoking cessation;South Carolina;Testing;Therapy trial;Time;Tobacco;tobacco control;tool;uptake;varenicline;Work

PROJECT_TITLE: A Translational Randomized Clinical Trial of Varenicline Sampling to Promote Smoking Cessation and Scalable Treatment Dissemination

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Natural Products;Nutrition

ORG_CITY: WILMINGTON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NORTH CAROLINA WILMINGTON

PHR: Project Narrative This project is relevant to public health because it will provide detailed information on the fate of substances found in Ashwagandha once they are ingested. These data will provide a picture of which components are altered during digestion and which original and altered compounds from Ashwagandha might be absorbed into the bloodstream; information that is critical for future studies examining Ashwagandha’s health effects.

PI_NAMEs: STRANGMAN, WENDY  (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: absorption;Affect;age related;Animals;anti-depressive agents;Anxiety;aqueous;Artificial Membranes;Ashwagandha;Ayurvedic Medicine;Biological Assay;Biological Availability;Biological Models;Blood Circulation;Botanical dietary supplements;Cell Membrane Permeability;Cellular Assay;Chemical Structure;Chemicals;Circulation;Clinical;Cognition;Complex;Complex Mixtures;Consumption;Coupled;Data;Deterioration;dietary supplements;Diffusion;Digestion;Drosophila genus;Drug Industry;Environment;Enzymes;Evaluation;Future;gastrointestinal;gut microbiome;Health;Health Benefit;improved;In Vitro;in vitro Assay;in vitro Model;in vivo;Incubated;Individual;Industry Standard;Ingestion;innovation;insight;interest;Intestinal Absorption;Intestines;Investigation;Laboratories;Liquid Chromatography;Liquid substance;Marketing;Mass Spectrum Analysis;maternal compound W;Medicine;Membrane;Metabolic;metabolic profile;metabolomics;Methods;Modeling;Names;National Center for Complementary and Integrative Health;Natural Products;Natural Remedy;Neurologic;Oral;Outcome Study;passive transport;Permeability;Pharmaceutical Preparations;Pharmacologic Substance;Plant Leaves;pre-clinical;Preparation;pressure;Process;Property;Protocols documentation;Public Health;Reaction;Reporting;Research;resilience;Resolution;Resources;sleep quality;Standardization;Statistical Data Interpretation;Testing;Time;time use

PROJECT_TITLE: Effects of digestion on composition and bioavailability of compounds from Ashwagandha: an in vitro study


ORG_DEPT: OTOLARYNGOLOGY

PHR: PROJECT NARRATIVE  There is a current and growing public health need for well-trained basic and clinician scientists, and physician scientists, to conduct research in otolaryngology and communication health to increase the science knowledge base and improve prevention, diagnosis, and treatment of disorders that decrease the lifespan and quality of life of men and women of all ages. This grant supports the continuation of Interdisciplinary Research Training in Otolaryngology and Communication Sciences, an integrated program based in the Department of Otolaryngology-Head and Neck Surgery at the Medical University of South Carolina. The goal is to provide mentored research opportunities in the disciplines related to otolaryngology and communication health, and the tools to become independent investigators and effective research team members whose work will increase understanding of mechanisms underlying these disorders and improve health outcomes.

PI_NAMEs: DUBNO, JUDY R (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Narrative This proposal focuses on research and training that are directly relevant to hearing loss, speech and language disorders, and communication disorders in humans. This training program will prepare a cadre of scientists to address fundamental questions pertaining to hearing and communication neuroscience. These individuals will not only advance our understanding of biologic and behavioral bases of a broad spectrum of auditory-vocal communication disorders, but will also generate innovative diagnostic and therapeutic applications.

PI_NAMEs: SHERA, CHRISTOPHER A (contact)

PROJECT_TITLE: Training in Hearing and Communication Neuroscience


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Telehealth

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE The prevalence of anxiety and depression are high among adolescents, but most ethnic minority adolescents in need do not access any MH care. The White House, the U.S. Surgeon General, the American Academy of Pediatrics, and the American Academy of Child and Adolescent Psychiatry, have all called for action to address the youth MH crisis and have highlighted accessible, effective school-based MH interventions for diverse students as a key strategy; research is needed to determine how to implement digital tools to improve mental health service access and outcomes for vulnerable youth served by school-based health centers.

PI_NAMEs: NADEEM, ERUM ;VAN METER, ANNA ROBINSON (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: Academy;acceptability and feasibility;Address;Adolescent;Adolescent Psychiatry;Adult;Affect;American;Anxiety;anxiety symptoms;barrier to care;Behavioral;Black race;Caring;Child Psychiatry;Clinical;Cognition;Communities;community advisory board;Consent;Coping Skills;cost;COVID-19;depressive symptoms;digital;digital health;digital healthcare;digital intervention;digital mental health;digital tool;Disease;disorder risk;Dose;Economics;Education;effective intervention;Effectiveness;effectiveness trial;effectiveness/implementation trial;emotion regulation;ethnic minority;Ethnic Origin;evidence base;Evidence based intervention;Exhibits;experience;Exposure to;Family;Feedback;Feeling suicidal;Focus Groups;Fright;functional improvement;Health Services Accessibility;Health Technology;high school;Hybrids;Immigrant family;implementation strategy;Improve Access;improved;innovation;Intervention;Interview;Judgment;Latinx;Low income;Mental Depression;Mental disorders;Mental Health;Mental Health Services;minority children;Moods;National Health Services;National Institute of Mental Health;Outcome;Outcome Assessment;pandemic disease;Parents;Participant;Pediatrics;peer;Persons;Phase;Population;Prevalence;Privacy;programs;Public Health;racial disparity;racial minority;Randomized;Randomized, Controlled Trials;reduce symptoms;Research;school based health center;School Health Services;Schools;screening;Services;social stigma;Stress;stressor;Students;substance use;suicidal risk;Suicide attempt;suicide rate;Surgeon;Symptoms;Technology;Testing;Transportation;trauma exposure;treatment as usual;university student;vulnerable adolescent;Youth

PROJECT_TITLE: Expanding minority youth access to evidence-based care: A pilot effectiveness trial of a digital mental health intervention

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Dietary Supplements;Genetics;Nutrition

ORG_DEPT: BIOLOGY

ORG_NAME: HERBERT H. LEHMAN COLLEGE

PHR: Project Narrative PUBLIC HEALTH RELEVANCE: Understanding signaling mechanisms for transceptors-mediated macro- and micro-nutrient sensing and uptake will contribute to improvement of human nutrition. In addition, transcriptional control has been the key to many physiological or pathological conditions, and thus the cooperative model of transcriptional control has a potential of providing protein targets for drug development in treating cancers and other diseases.

PI_NAMEs: ZHENG, ZHI-LIANG  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Alleles;Amino Acids;Arabidopsis;Binding;Biochemical;C-terminal;Cell membrane;Cell Nucleus;Cells;Code;Complex;Cytoplasm;detection of nutrient;Disease;drug development;Drug Targeting;Elements;Enhancers;Environment;Eukaryota;Event;Family;FHL1 gene;fungus;gain of function;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Growth and Development function;Guanosine Triphosphate Phosphohydrolases;Human;improved;inorganic phosphate;insight;Lead;Link;loss of function;Malignant Neoplasms;MAP Kinase Modules;Measures;Mediating;member;Micronutrients;Minerals;Modeling;Modification;Monomeric GTP-Binding Proteins;mutant;Nitrates;novel;Nutrient;nutrition;Organism;Pathologic;Pathway interactions;Pattern;Peptides;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Physiological;Plant Model;Plants;Polymerase;Post-Translational Protein Processing;Productivity;promoter;protein degradation;protein function;Proteins;public health relevance;receptor;recruit;Regulatory Element;Reporting;Research;response;rho;rho GTP-Binding Proteins;RNA Polymerase II;RNA polymerase II largest subunit;Role;sensor;Signal Transduction;Sulfate;sulfate transporter;Sulfur;System;Testing;transcription factor;transcription factor TFIIH;Transcription Initiation;Transcriptional Regulation;uptake;Work;Yeasts;Zinc

PROJECT_TITLE: Role of ROP GTPases in sulfate transceptor SULTR1;2-regulated sulfur nutrient sensing


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

PHR: Narrative: This T32 Training Program is dedicated to the training of the next generation of environmental health scientists by emphasizing training in translational research that transcends basic and population based research, patient oriented research, community engagement and public health policy.

PI_NAMEs: PENNING, TREVOR M (contact);SIMMONS, REBECCA A

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Environmental Health;Training Programs;Translational Research

PROJECT_TITLE: Translational Research Training Program in Environmental Health Sciences

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(T)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Estrogen;Genetics;Infectious Diseases;Sexually Transmitted Infections;Urologic Diseases;Women's Health Research

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Worldwide, Neisseria gonorrhoeae (Ng) is one of the most common sexually transmitted bacterial diseases. These bacterial infections cause pelvic inflammatory disease that can lead to infertility, ectopic pregnancy and chronic pelvic pain and have been associated with increased transmission of HIV. We will examine how Ng manages to evade the immune system to enhance its ability to infect females by exploiting an estrogen- induced anti-viral protein called interferon epsilon.

PI_NAMEs: GOLENBOCK, DOUGLAS T (contact);RAM, SANJAY

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Affect;Anti-Bacterial Agents;Antibiotics;antimicrobial;Antimicrobial Cationic Peptides;Attenuated;Bacteria;Bacterial Adhesion;Bacterial Infections;Bacterial Sexually Transmitted Diseases;bactericide;cathelicidin antimicrobial peptide;cell type;Cells;Cervical;chemokine;chronic pelvic pain;Complement;Cytidine Monophosphate N-Acetylneuraminic Acid;cytokine;Cytometry;Data;Dichloromethylene Diphosphonate;Drug-resistant Neisseria Gonorrhoeae;Ectopic Pregnancy;Effector Cell;efflux pump;enhancing factor;Environment;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Epithelium;Estrogen Therapy;Estrogens;Female;female reproductive tract;female reproductive tract infection;Gene Expression;Genes;Gonadal Steroid Hormones;Gram-Negative Bacteria;HIV;Hormones;Host Defense;Human;human model;Immune;Immune Evasion;Immune system;in vivo;Incidence;Infection;Infertility;Inflammation;Innate Immune Response;Interferon alpha;Interferons;Invaded;Knock-out;knockout animal;Knockout Mice;Leukocytes;Lipid A;lipooligosaccharide;Lipopolysaccharides;Mediating;Menstrual cycle;Metabolism;Molecular;Monoclonal Antibodies;mouse model;Mus;Myeloid Cells;Neisseria gonorrhoeae;neutralizing monoclonal antibodies;Nucleic Acids;pathogenic bacteria;Pathway interactions;Pattern;Pelvic Inflammatory Disease;Phagocytes;Phase;Phenotype;phosphoethanolamine;Play;Predisposition;prevent;Production;Productivity;Proteins;Proteomics;Public Health;receptor;Receptor Signaling;Recombinant Interferon;recruit;Regulation;reproductive tract;Resistance;response;Role;Sexual Transmission;Sexually Transmitted Diseases;sialic acid binding Ig-like lectin;Sialic Acids;sialylation;Sialyltransferases;Signal Transduction;Tissues;transcriptome sequencing;transmission process;type I interferon receptor;urogenital tract;Vagina;Viral Proteins;virtual;Wild Type Mouse;Woman

PROJECT_TITLE: Neisseria gonorrhoeae exploits host interferon epsilon to establish infection in the female urogenital tract

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Nutrition;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Food insecurity and social isolation are social risks that affect a wide variety of health outcomes, and commonly co-occur. To improve health and reduce health inequities, effective strategies to address food insecurity and social isolation are critically necessary, particularly among medically underserved populations with chronic conditions such as diabetes. If the proposed aims are achieved, a combination of group medical visits and produce prescriptions may prove a viable model for addressing social isolation and food insecurity in primary care settings.

PI_NAMEs: THOMPSON-LASTAD, ARIANA LAUREN (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Address;Adoption;Adult;Affect;Asian;Black race;California;career;career development;Caring;Centers for Population Health;Chronic;Clinic;Clinical Trials;Communities;comparison group;County Government;COVID-19 pandemic;Data;design;Development;Diabetes Mellitus;Disparity;effectiveness testing;effectiveness/implementation study;Elderly;Electronic Health Record;Ensure;Environment;ethnic diversity;Ethnic Origin;experience;Farm;Federally Qualified Health Center;Focus Groups;Food;Food Access;food insecurity;fruits and vegetables;Funding;future implementation;Glycosylated hemoglobin A;Goals;Health;Health Benefit;health care service utilization;health care settings;health disparity;Health education;health equity;Health equity research;health inequalities;Health Surveys;Home;Household;Human;Immigrant family;implementation evaluation;improved;innovation;Intervention;Interview;K-Series Research Career Programs;Latino;Linguistics;literacy;Low income;Maintenance;Managed Care Programs;Measurement;Medicaid;Medical;medically underserved population;Mental Health;Mentored Research Scientist Development Award;Mentors;Methods;Modeling;mortality;Multilingualism;Natural experiment;nutrition;nutrition education;Observational Study;Outcome;patient oriented;patient population;Patients;peer support;Persons;physical conditioning;Population;Practice based research;Primary Care;primary care setting;process evaluation;programs;Qualitative Methods;Qualitative Research;Race;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;research and development;Research Methodology;Research Personnel;Research Support;responsible research conduct;Risk;Role;San Francisco;Site;social;social influence;Social isolation;Spanish;Spanish/English;Structure;synergism;telehealth;Time;Training;transportation access;treatment as usual;United States Department of Agriculture;Universities;Visit

PROJECT_TITLE: Produce Prescriptions and Group Medical Visits: Addressing Food Insecurity and Social Isolation in Primary Care


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: Auburn

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: Project Narrative for The Development and Experimental Verification of Computational  Methods to Design Therapeutic Proteins  Binding proteins such as antibodies are among the most important tools in modern medicine, but they still have limitations. The proposed research will allow for the design of proteins with better properties that are less expensive to produce in far less time than current methods. This will allow doctors to respond to medical threats, whether they are cancer, a new antibiotic-resistant bacteria, or an emerging pandemic, in near real time, thereby saving the lives of individuals that current technologies cannot help.

PI_NAMEs: PANTAZES, ROBERT J (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Amino Acids;Antibodies;Antigens;Autoimmune Diseases;Bacterial Antibiotic Resistance;Binding;Binding Proteins;clinical application;Computer software;Computing Methodologies;Consumption;design;Development;Enzymes;Epitopes;fighting;flexibility;Foundations;Health;Immune response;Immune system;improved;Individual;Malignant Neoplasms;Medical;Methods;Modern Medicine;new pandemic;novel;Outcome;Patients;Peptides;Personal Computers;personalized cancer therapy;Property;Protein Engineering;Proteins;Research;Rest;Selection Criteria;Technology;therapeutic protein;Time;tool;Universities;Validation

PROJECT_TITLE: The Development and Experimental Verification of Computational Methods to Design and Predict the Properties of Therapeutic Proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biotechnology;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Gene Therapy;Genetics;Infectious Diseases;Nanotechnology;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_NAME: XAVIER UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Resistance to chemotherapeutic drugs such as doxorubicin is a major reason for cancer treatment failure. The development of a targeted nanocarrier system that increases the delivery of doxorubicin into chemoresistant breast cancer cells will lead to enhanced cellular toxicity and antitumor effects as a result of the enhanced knock-down of multidrug resistant genes.

PI_NAMEs: KUNDU, ANUP KUMER (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: ABCB1 gene;ABCC1 gene;ABCG2 gene;Acids;Address;anti-cancer;anti-cancer therapeutic;Antineoplastic Agents;antitumor effect;aptamer;Aptamer Technology;ATP-Binding Cassette Transporters;Binding;Breast Cancer Cell;Breast Cancer therapy;Breast Cancer Treatment;Bypass;cancer cell;cancer drug resistance;cancer therapy;Cardiomyopathies;Cardiotoxicity;Cells;Chemoresistance;Chemotherapy-Oncologic Procedure;clinical application;Clinical Research;cytotoxicity;delivery vehicle;Deposition;Development;Disease;Disseminated Malignant Neoplasm;DNA;Dose;Doxorubicin;Drug resistance;Encapsulated;Failure;Formulation;Genes;Goals;innovation;knock-down;Label;lipid nanoparticle;Liposomal Doxorubicin;Liposomes;liver injury;Malignant Breast Neoplasm;Molecular Conformation;Multi-Drug Resistance;Multidrug Resistance Gene;nanocarrier;nanoparticle;nanoparticle delivery;Nanotechnology;neoplastic cell;Normal Cell;Normal tissue morphology;Nuclear;Oligonucleotides;Outcome;overexpression;particle;Pharmaceutical Preparations;Polymers;prevent;Proteins;receptor;Reporting;Resistance;Resistance development;resistance gene;RNA;RNA Interference;side effect;siRNA delivery;Small Interfering RNA;Specificity;System;targeted delivery;Testing;Therapeutic;Tissues;Toxic effect;Treatment Failure;uptake

PROJECT_TITLE: Formulation of a targeted nanoparticle system for the treatment of chemoresistant breast cancer


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT LAY NARRATIVE The incidence of dizziness increases from 22% for adults between the ages of 65 and 69 to over 40% between the ages of 80 and 84 years, and fall-related injuries are highly correlated with reports of dizziness, constituting the sixth leading cause of death in the elderly and associated with a 20% mortality rate. We will identify the genes and pathways involved in the vestibular portion of the balance system of humans and aged mice, compare the genomic composition of human and mouse vestibular tissues, then test the hypothesis that the genes and/or pathways identified are critical to balance function. Our team will combine resources with the expertise of a neurotologist, otolaryngologist/data scientist, computational biologists, and neurogeneticists to identify genes and pathways underlying imbalance, leading to targeted therapies for prevention and treatment of imbalance and falls in the elderly.

PI_NAMEs: CLIFFORD, ROYCE ELLEN;FRIEDMAN, RICK A (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Acceleration;Adult;Affect;Age;age related;aged;Aging;aging process;American;Anatomy;Animal Disease Models;Animal Model;Atherosclerosis Risk in Communities;Atlases;Behavioral;biobank;Biology;Candidate Disease Gene;candidate identification;Catalogs;Cause of Death;cell type;Cells;Cerebellum;Cessation of life;cohort;comparative;Complex;Computational Biology;Computing Methodologies;Data;data integration;Data Scientist;Data Set;DCC gene;Death Rate;Development;Discipline;Dizziness;effective therapy;Elderly;Equilibrium;Evoked Potentials;FAIR principles;fall injury;falls;Force of Gravity;Foundations;functional decline;Functional disorder;Future;ganglion cell;Gene Expression;Gene Expression Profiling;gene network;Genes;Genetic;genetic analysis;genetic architecture;Genetic Transcription;genome wide association study;genomic locus;Genomics;Goals;Hair Cells;Head;hereditary hearing loss;Heritability;Human;human data;Human Genetics;Human Genome;human model;human old age (65+);human subject;Hybrids;in vivo;Incidence;Individual;innovation;Intervention;Knock-in Mouse;Knock-out;Knowledge;large datasets;Literature;Measures;Mediating;Meta-Analysis;Methodology;Motion;mouse genome;mouse model;multidisciplinary;Mus;Muscle;National Institute on Deafness and Other Communication Disorders;Nerve Fibers;Neuroanatomy;Neurons;old mice;older adult;Operative Surgical Procedures;Organ;Otolaryngologist;Outcome;Pathway Analysis;Pathway interactions;Performance;Pharmacologic Substance;Phenotype;Physiological;Population;Prevention;Prevention therapy;programs;PTK2 gene;Publications;Purkinje Cells;Quantitative Trait Loci;receptor;receptor function;Reporting;Resources;response;Rodent Model;Saccule and Utricle;sensor;Sensory;single cell sequencing;single-cell RNA sequencing;Site;Specimen;System;targeted treatment;Testing;Therapeutic Intervention;Tissues;trait;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Translations;Validation;Variant;Vestibular dysfunction;Vestibular function;Vestibular ganglion;Vestibular nucleus structure;vestibular system;Veterans;Women's Health;Work

PROJECT_TITLE: The genetics of functional decline in the aging vestibular system: A GWAS and gene expression analysis in aging mice and humans


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome;Kidney Disease;Orphan Drug;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: A triumvirate of interacting regulatory elements co-exist on chromosome 3, which is commonly lost in human clear cell renal cell carcinoma, contributing to haploinsufficiency, with loss of heterozygosity driving disease progression. This study will explore the unique interplay between these factors (methylation writers, readers, and erasers) at the mitotic spindle that sets the stage for renal carcinogenesis. We further identify and define key nodes at which pharmacologic strategies provide the opportunity to explore therapeutic intervention.

PI_NAMEs: DERE, RUHEE ;MASON, FRANK M (contact);WALKER, CHERYL L.

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Address;Alleles;aurora kinase;aurora kinase A;Automobile Driving;Biochemical;Biological Assay;Biology;carcinogenesis;Cell division;Cells;Centrosome;Chromatin;chromatin remodeling;Chromosome 3;chromosome 5q loss;Chromosome abnormality;Chromosomes;Clear cell renal cell carcinoma;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Complex;Cytoskeleton;Data;Defect;Development;Disease;Disease Progression;Dropout;Equilibrium;Etiology;Evolution;Failure;Genes;genome integrity;Genome Stability;Genomic Instability;Genomics;Heterozygote;histone methyltransferase;Histones;Human;innovation;insight;Intervention;Kidney;Link;loss of function;Loss of Heterozygosity;Lysine;Malignant Neoplasms;Mediating;member;Methylation;Methyltransferase;Microtubules;Mitosis;Mitotic;Mitotic spindle;Modeling;Molecular;mutant;Mutation;novel;novel therapeutic intervention;Oncogenic;Organoids;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;preservation;prevent;Proteins;Publishing;Reader;recruit;Regulation;Regulatory Element;Reporting;Role;Route;screening;Specimen;targeted treatment;Testing;therapeutic evaluation;Therapeutic Intervention;Time;tool;Tubulin;tumor;Tumor Suppression;Tumor Suppressor Proteins;ubiquitin isopeptidase;ubiquitin-protein ligase;Work

PROJECT_TITLE: Convergent Drivers of Tumor Evolution at the Mitotic Spindle

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-J(02)M]


ED_INST_TYPE: COMPUTER CENTER

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE In eukaryotes, transcriptional regulation is essential to maintaining cell identity, responding to intra- and extra-cellular signals, and coordinating various cellular activities, whereas dysregulations in this process can cause a broad range of diseases. Parallel multi-omics single- cell sequencing now becomes a routine technique to reveal the transcriptional regulatory mechanisms at the finest resolution possible, but its computational modeling is still in its infancy due to its ultra-high dimensionality, complex feature interactions, and high vulnerabilities to numerous confounding factors. This research aims to develop a suite of interpretable deep learning models and open-source software to construct personalized regulome via flexible single- cell multiome integration, which will push our understanding of transcriptional regulation to a single cell resolution and allow direct prioritizations of key dysregulations associated with genetic disorders.

PI_NAMEs: ZHANG, JING  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: 3-Dimensional;Adult;Age;Base Pairing;Benchmarking;Biological;Biological Assay;Boundary Elements;Brain;California;cell type;Cells;ChIP-seq;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Collaborations;Communities;Complex;Computational Biology;computational suite;Computer Models;Computer software;computerized data processing;Data;data integration;deep learning model;dimension reduction;Disease;Dropout;Engineering;epigenome;Eukaryota;Event;Excision;extracellular;flexibility;functional genomics;Gender;Gene Expression Regulation;Generations;generative models;Genes;Genetic Diseases;genetic risk factor;Genetic Transcription;Genome;genome annotation;genomic profiling;Genomics;Genotype;Heterogeneity;Hi-C;high dimensionality;Human;Hybrids;Individual;infancy;Label;Learning;Link;Machine Learning;member;Methods;Modality;Modeling;multimodality;Multiomic Data;multiple omics;neural;open source;Performance;Phenotype;Process;reconstruction;Regulation;Regulatory Element;Reporting;Research;Resolution;Risk Factors;Sampling;Scheme;Scoring Method;Sensitivity and Specificity;sequencing platform;Signal Transduction;single cell sequencing;single cell technology;Specificity;supervised learning;Techniques;Tissues;tool;transcription factor;Transcriptional Regulation;transcriptome;ultra high resolution;Universities;Untranslated RNA;user friendly software;Validation;Variant

PROJECT_TITLE: Decoding the Noncoding Regulatory Genome with Super-resolution via Single-cell Multiomics Integration

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE This application focuses on improving diagnostic accuracy of developmental language disorder (DLD), a chronic developmental disorder occurring in 7% of the US population that negatively impacts children's long-term social, educational, and vocational outcomes. The proposed project will be the first to investigate DLD markers in Vietnamese bilingual and monolingual children. Outcomes include validated tools for accurate identification, which in turn will increase access to intervention to relieve the burden of the disorder for children who speak Vietnamese as a first language (spoken by 1.5 million in the US and 100 million worldwide).

PI_NAMEs: PHAM, GIANG THUY (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TITLE: Clinical markers of DLD in bilingual and monolingual Vietnamese children

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: Project Narrative Cryogenic Electron Microscopy (cryo-EM) has become a major technology to determine the structures of proteins, particularly large protein complexes and assemblies, but reconstructing protein structures from cryo-EM images data is still a time-consuming, labor-intensive, and inaccurate process. This project will develop deep learning methods to automatically and accurately build protein structures from cryo-EM images, which will be useful tools to advance structural biology and structure-based biomedical research and technology development.

PI_NAMEs: CHENG, JIANLIN  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: 3-Dimensional;Algorithms;Attention;autoencoder;Biomedical Research;Communities;Complex;Computer software;Consumption;convolutional neural network;Cryoelectron Microscopy;Data;deep learning;deep learning model;denoising;density;Development;electron density;Equipment;Homology Modeling;Human;Image;image processing;improved;Individual;Ion Channel;Laboratories;Machine Learning;machine learning method;machine learning pipeline;Manuals;Maps;markov model;mathematical methods;Membrane;Membrane Proteins;Methods;microscopic imaging;Modeling;Natural Language Processing;Noise;novel;Nuclear Magnetic Resonance;open source;particle;Positioning Attribute;prevent;Process;protein complex;protein data bank;protein structure;Proteins;reconstruction;recurrent neural network;research and development;Resolution;Rotation;Signal Transduction;Software Tools;Software Validation;Statistical Methods;structural biology;Structure;supervised learning;Techniques;Technology;technology development;Testing;three dimensional structure;Time;tool;Training;Translations;unsupervised clustering;unsupervised learning;Vertebral column;Work;X-Ray Crystallography

PROJECT_TITLE: Deep learning methods for automated and accurate reconstruction of protein structures from cryo-EM image data


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: COLLEGE STATION

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: PROJECT NARRATIVE Therapeutic interventions, such as exposure therapy, reduce pathological fear in patients with anxiety disorders—but this fear reduction is often transient and vulnerable to relapse. The impermanence of extinction-based therapy is a major challenge to clinical interventions for a host of disorders, including anxiety and post-traumatic stress disorder. Therefore, the long-term goal of this project is to understand the neural substrates of extinction, particularly the specific brain circuits involved in the contextual retrieval of extinguished fear memories.

PI_NAMEs: MAREN, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Amygdaloid structure;anatomical tracing;Anxiety;Anxiety Disorders;Area;Binding;Brain;Clinic;Clinical;Communication;conditioned fear;Conditioned Stimulus;Coupling;Data;Dependence;Disease;emotion regulation;emotional behavior;Extinction;fear memory;Fostering;Freezing;Fright;Funding;Genetic;Goals;Hippocampus;Human;Impairment;Individual;innovation;Intervention;Label;Lead;Learning;learning extinction;Medial;Mediating;Memory;memory encoding;memory retrieval;Mental disorders;neural;neural circuit;Neurons;novel;optogenetics;Pathologic;Pathway interactions;Patients;pharmacologic;Phase;Post-Traumatic Stress Disorders;Prefrontal Cortex;prevent;Process;Rattus;Relapse;relapse prevention;Reporting;Retrieval;Reuniens Thalamic Nucleus;Role;Safety;System;Testing;Thalamic structure;Therapeutic Intervention;Trauma;Viral;Work

PROJECT_TITLE: Neural Substrates of Contextual Memory in Fear Extinction


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: DETROIT

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project Narrative The Center for Leadership in Environmental Awareness and Research (CLEAR) proposes an integrated, transdisciplinary framework, rooted in advanced techniques in environmental engineering and biomedical research, to address human exposure routes and health risks from volatile organic compounds (VOCs) in urban areas. Research findings on (a) the relationship between VOC exposure and human health risks—for preterm birth and associated adverse health outcomes in particular—combined with (b) new methods and technologies to assess, communicate, and reduce those health risks, and (c) a new understanding of related biological systems, will contribute to improved public health interventions. CLEAR research is expected to have a direct impact on affected communities, stakeholders, and the agencies responsible for reduction of environmental VOC exposure and for Superfund site management.

PI_NAMEs: MILLER, CAROL JEAN;RUNGE-MORRIS, MELISSA A (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: Address;adverse birth outcomes;Adverse effects;Affect;Aging;Awareness;Bayesian Modeling;Behavioral;Benzene;Biological;Biological Assay;Biological Markers;biological systems;Biomedical Research;Birth;Birth Rate;built environment;Businesses;Chemicals;Child Health;Cities;Collaborations;college;Communication;Communities;community engagement;Complex;Computing Methodologies;cost;Country;Data;Data Analyses;data management;Dedications;design;Detection;Development;Documentation;Education;Engineering;Ensure;Environmental Engineering technology;Environmental Health;Environmental Impact;Environmental Pollution;Environmental Science;Epidemiologic Methods;ethylbenzene;Etiology;experience;exposed human population;exposure pathway;exposure route;Exposure to;Faculty;Fetal health;Gases;Great Lakes Region;ground water;Hazardous Substances;Health;Health system;Home;Human;Immune;Immunologics;improved;Industrialization;Inflammation;Inflammatory Response;Infrastructure;innovation;Institution;Internet of Things;Intervention;Knowledge;Laboratories;landfill;Leadership;Life;Link;Maps;Maternal Health;Methodology;Methods;Michigan;Minority Groups;model organism;Modeling;mouse model;Neurologic;next generation;novel;offspring;Outcome;Participant;Pathway interactions;Phase;Placenta;Plants;Play;pollutant;Predisposition;Pregnancy Outcome;pregnant;Premature Birth;prevent;programs;Property;Public Health;public health emergency;public health intervention;real time model;remediation;Reporting;reproductive;Research;Research Activity;research and development;Research Project Grants;residence;response;Risk;Risk Assessment;risk mitigation;Role;Sampling;Schools;Science;Scientist;seal;sensor technology;Site;Soil;Specimen;Superfund;superfund site;System;Targeted Research;Techniques;Technology;Testing;Tetrachloroethylene;Time;Tissues;Toluene;Toxic effect;Toxicant exposure;Training;Translating;Translational Research;Translations;Trichloroethylene;Universities;urban area;urban setting;vapor;vapor intrusion;Visualization software;volatile organic compound;Workplace;Xylene;Zebrafish


NIH_SPENDING_CATS: Health Effects of Indoor Air Pollution

PHR: Project Narrative Exposure to volatile organic compounds (VOCs) has, in recent years, been of increasing concern because of the heightened awareness of vapor intrusion into basements and resulting impacts on public health. Our ability to address this public health issue is limited by our ability to identify belowground VOC contamination in a spatially comprehensive and cost-efficient way. CLEAR’s (Center for Leadership in Environmental Awareness and Research) Project E1 provides proof-of-concept for using aboveground plant tissue to provide data identifying hot spots and sources of belowground VOCs that can be integrated into a geospatial GIS framework; metrics from our geospatial GIS framework and metrics of public health concern can be spatially correlated to focus remediation and/or mitigation.

PI_NAMEs: HOOD, GLEN RAY (contact)

PROJECT_TERMS: Address;Architecture;Area;Awareness;Benzene;Biological;Biomedical Research;Characteristics;Chemicals;Cities;Collaborations;Communities;community engagement;Complex;contaminant transport;cost effective;cost efficient;Data;Data Analyses;data management;data sharing;Dedications;Development;Effectiveness;effectiveness evaluation;Environment;Environmental Health;ethylbenzene;experience;Exposure to;Goals;ground water;Hazardous Substances;Health;health data;Hot Spot;Human;hydrology;improved;indoor air;Indoor Air Quality;Industrialization;Infiltration;Infrastructure;innovation;interest;Leadership;Link;Maps;member;method development;Methods;minimally invasive;Modeling;Monitor;offspring;Outcome;Plants;Positioning Attribute;Precipitation;Predisposition;Premature Birth;Privatization;Problem Solving;Process;Property;Public Health;remediation;Research;residence;Risk Assessment;Sampling;Scheme;Signal Recognition Particle;Soil;Source;stable isotope;Superfund;Techniques;Technology;Testing;Tetrachloroethylene;theories;Time;Tissues;Toluene;Toxic effect;Training;Trichloroethylene;uptake;Urban Community;urban setting;vapor;vapor intrusion;volatile organic compound;Water;Work;Xylene

PROJECT_TITLE: E1 - Building Aboveground Strategies to Identify and Address Belowground Hot Spots for VOC Vapor Intrusion in Complex Urban Settings


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: FORT COLLINS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Non-learned defensive behaviors are necessary for survival, like fleeing or freezing in the face of threat. How these behaviors are changed depending on the circumstances, however, is not known. We will test whether the cerebellum, a brain region involved in the coordination of movement, modulates defensive behaviors.

PI_NAMEs: VAAGA, CHRISTOPHER EDWARD (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Amygdaloid structure;Animals;Behavior;behavior change;Behavior monitoring;Behavioral;behavioral outcome;behavioral response;Biological Assay;Brain region;Cerebellar Nuclei;Cerebellum;Complex;conditioned fear;Conditioned Stimulus;Coupled;Dedications;Detection;Dopamine;dopaminergic neuron;Environment;experimental study;fear memory;Fiber;flexibility;Foundations;Freezing;Fright;Goals;habituation;Heterogeneity;Impairment;in vivo;induced pluripotent stem cell;Interneurons;Learning;Lesion;Medial;midbrain central gray substance;Midbrain structure;Monitor;Motor Neurons;Movement;Mus;Muscle;Nature;neural circuit;Neurons;Optics;optogenetics;Output;Pattern;Photometry;Play;Predatory Behavior;Property;response;Role;sex;Signal Transduction;Source;Synapses;System;Techniques;Testing;Wild Type Mouse;Work

PROJECT_TITLE: Cerebellar Modulation of Innate Defensive Behaviors

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Bioengineering;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

PHR: Project Narrative – Project E2 Project Narrative The Center for Leadership in Environmental Awareness and Research (CLEAR) is dedicated to understanding and mitigating human exposures to volatile organic compounds (VOCs) and health risks in urban areas. Assessing and remediating VOC vapor intrusion (VI) is challenging due to the complexity and high cost of off- line sampling methods and conventional engineering remediation strategies. CLEAR Project E2 transforms the paradigm of VI assessment and remediation from conventional off-line methods to a new data-science driven approach and provides a first-of-its-kind platform with functionality ranging from real-time VI monitoring and data collection/analysis to data-based decision making and improved remediation outcomes.

PI_NAMEs: WAGER, YONGLI  (contact)

PROJECT_TERMS: Address;Adsorption;Aging;Air;air sampling;Awareness;Bayesian Modeling;Bayesian Network;Benzene;Biological;Carbon;Chemicals;Cities;clay;Collaborations;Collection;Complement;Complex;cost;cost efficient;Coupled;Data;Data Collection;Data Science;Data Sources;Decision Making;Dedications;design;Development;Disparity;energy efficiency;Engineering;Environment;Environmental Health;environmental justice;Environmental Monitoring;Environmental Risk Factor;Exhibits;exposed human population;Exposure to;Face;Funding;Future;Goals;ground water;Hazardous Substances;Health;Home;Human;improved;Industrialization;Industry Standard;Inequity;Infrastructure;innovation;Internet of Things;Kinetics;Lead;Leadership;Low income;Machine Learning;machine learning algorithm;Methods;Minority;Mission;Modeling;Modification;Monitor;novel;offspring;Outcome;particle;Pathway interactions;Pattern Recognition;Performance;Population;practical application;Premature Birth;Property;Public Health;remediation;Research;Research Personnel;Research Project Grants;response;Risk;Risk Assessment;risk prediction model;Sampling;Scientific Advances and Accomplishments;sensor;Signal Recognition Particle;Signal Transduction;Site;Soil;Source;stem;Superfund;Surveys;System;Technology;Testing;Tetrachloroethylene;Time;Toluene;tool;Toxic effect;Trichloroethylene;urban area;urban setting;vapor intrusion;Variant;volatile organic compound;Water;water sampling;web platform;Work;Zeolites

PROJECT_TITLE: Integrated IoT Sensing and Edge Computing Coupled with a Bayesian Network Model for Exposure Assessment and Targeted Remediation of Vapor Intrusion


NIH_SPENDING_CATS: Health Effects of Indoor Air Pollution;Prevention;Social Determinants of Health

PHR: Project Narrative: This project will provide a better understanding of reproductive, developmental, immunological, neurobehavioral, and multigenerational health effects of a wide-range of individual VOCs and VOC mixtures in zebrafish, including combinations and concentrations of VOC contamination similar to those found in the homes and environments of our target population in Detroit, MI. CLEAR Project B1 will identify specific genetic and epigenetic biomarkers associated with each VOC exposure and their potential impacts on subsequent generations. Results will be utilized by the Community Engagement Core to aid the community, policy-makers, physicians, and other stakeholders to implement prevention and intervention measures to protect public health.

PI_NAMEs: BAKER, TRACIE R (contact)

PROJECT_TERMS: Acute;Address;Adsorption;Adult;Advanced Development;adverse outcome;anthropogenesis;aquatic organism;Awareness;Behavior assessment;Behavioral Assay;Biological;Biological Assay;Biological Markers;biomarker validation;Birth Rate;candidate marker;Cardiovascular system;Chemicals;Child;Chronic;Collaborations;Communities;community engagement;Complex Mixtures;Congenital Abnormality;consumer product;contaminated fish;Country;Data;Data Analyses;Dedications;Dermal;Development;Disease;Dose;Endocrine system;Ensure;Environment;environmental chemical;Environmental Health;Environmental Impact;Environmental Pollutants;epigenetic marker;Epigenetic Process;epigenetic regulation;Evaluation;evidence base;exhaust;experimental study;exposed human population;Exposure to;Generations;Genes;Genetic Markers;Genome;Goals;ground water;Health;health assessment;health of the mother;Hepatic;Home;Human;Immune;immune function;immune health;Immune system;Immunologics;Impairment;improved;Individual;indoor air;Industrialization;Ingestion;Inhalation;innovation;interest;Intervention;Kidney;Knowledge;Leadership;Life;Link;Measures;Mediating;Mission;model organism;Modeling;Molecular;Monitor;Multiple Abnormalities;Nervous System;neurobehavioral;Neurologic;neurotoxicity;novel;off-gassing;Outcome;Pathway interactions;Phenotype;Physicians;placental mammal;Policy Maker;Population;Positioning Attribute;potential biomarker;Pregnant Women;Premature Birth;prevent;Prevention;programs;Public Health;reproductive;Reproductive Health;Research;Research Project Grants;Research Proposals;Research Training;respiratory;Risk;Risk Assessment;Route;seal;Signal Recognition Particle;Source;Superfund;superfund site;System;Target Populations;Techniques;Technology;Testing;Therapeutic;Toxic effect;toxicant;transcriptomics;translational impact;Transport Process;United States National Institutes of Health;urban area;urban setting;vapor intrusion;volatile organic compound;Water;Work;Zebrafish

PROJECT_TITLE: Developmental VOC Exposure in Zebrafish:  Toxic Mechanisms and Biomarkers


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Atherosclerosis (thickening and hardening of the blood vessels) is a leading cause of death in the US. We plan to test new nanoparticle-based therapies to promote vessel health treating vascular disease.

PI_NAMEs: FANG, YUN  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TITLE: Precision nanomedicine targeting novel endothelial mechano-sensing mechanisms


NIH_SPENDING_CATS: Behavioral and Social Science;Endocrine Disruptors;Health Effects of Indoor Air Pollution;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

PHR: Project Narrative The Center for Leadership in Environmental Awareness and Research (CLEAR) has built an integrated, transdisciplinary framework, rooted in advanced techniques in environmental engineering and biomedical research, to address human exposures to volatile organic compounds (VOCs) and health risks in urban areas. Research findings on (a) the relationship between VOC exposure and human health risks—for preterm birth and related health outcomes in particular—combined with (b) new methods and technologies to assess and reduce those health risks, and (c) a new understanding of related biological systems, will contribute to improved public health interventions. CLEAR research is expected to have a direct impact on affected communities, stakeholders, and the agencies responsible for Superfund site management and the reduction of environmental VOC exposure. Project B2 uses a mouse model to decipher the signaling pathways by which exposure to VOCs during pregnancy have an impact on early life growth and development with a particular focus on the developing fetal immune system.

PI_NAMEs: MOR, GIL G (contact)

PROJECT_TERMS: Abbreviations;Address;Affect;Air Pollutants;American;Area;Asthma;Awareness;B-Lymphocytes;Benzene;Biological;biological systems;Biomedical Research;Birth;Birth Rate;Chemical Exposure;Chemicals;Child;Chronic Disease;Cities;Clinical;Communicable Diseases;Communities;community engagement;Consultations;Data;Data Analyses;data integration;data management;Decidua;Dedications;Development;Dose;Environmental Engineering technology;Environmental Health;Epidemiology;epidemiology study;ethylbenzene;Etiology;exposed human population;Exposure to;fetal;Fetal Development;Fetal Growth Retardation;fetal programming;Fetus;Fishes;Future;ground water;Growth;Growth and Development function;Health;Homing;Household;Human;Immune;immune activation;Immune response;Immune system;implantation;improved;in utero;Incidence;Industrialization;Infant;Infection;Inflammation;Inflammatory;Inhalation;Inhalation Exposure;Leadership;Life;Link;Liver;Maternal Exposure;maternal morbidity;maternal outcome;Methods;microbial;microorganism;Modeling;Modification;Molecular;mortality;Mothers;mouse model;Mus;Nature;Neonatal;neonatal morbidity;neonate;Newborn Infant;Occupational;offspring;Outcome;Pathogenesis;Personal Satisfaction;Phenotype;Placenta;Play;postnatal;Pre-Eclampsia;preclinical study;Predisposition;Pregnancy;Pregnancy Complications;Premature Birth;prenatal exposure;Process;Property;public health emergency;public health intervention;pup;Receptor Signaling;Reporting;Research;response;Risk;Role;Severities;Signal Pathway;Site;Soil;stressor;Superfund;superfund site;System;T cell differentiation;T-Lymphocyte;Techniques;Technology;Testing;Thymus Gland;Toll-like receptors;Toluene;Toxic effect;Training;urban area;Vaccines;vapor intrusion;Viral;volatile organic compound;Volatilization;Xylene;Zebrafish

PROJECT_TITLE: Impact of BTEX Chemical Exposure During Pregnancy to Maternal and Fetal Well-Being


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

PHR: Volatile organic compounds (VOCs) contaminate shallow soils and groundwater at Superfund, residential, commercial, and industrial properties, leading to exposures via vapor intrusion; available data suggests that VOCs are associated with higher risk for preterm birth (PTB). The Center for Leadership in Environmental Awareness and Research (CLEAR) is dedicated to understanding and mitigating this serious environmental health problem. CLEAR Project B3 will specifically address the impact of VOCs on PTB risk through an epidemiologic study of pregnant women in metropolitan Detroit; additionally, B3 will examine if VOCs are associated with altered maternal inflammation or placental function (DNA methylation, gene expression) and potential sources of VOC exposure, which may yield insights into interventions to prevent adverse pregnancy outcomes and/or areas to target for VOC remediation.

PI_NAMEs: CASSIDY-BUSHROW, ANDREA E (contact)

PROJECT_TERMS: 37 weeks gestation;Address;adduct;adverse pregnancy outcome;Affect;Animals;Area;Awareness;Benzene;Biological;Biological Markers;Birth;Birth Rate;black women;Blood;Blood specimen;Chemicals;Chronic Disease;Circulation;Cities;Clinical;cohort;Collaborations;community engagement;Complex;cost;Data;Data Analyses;data management;Dedications;Deterioration;Disease;DNA Methylation;Engineering;Ensure;Environment;Environmental Exposure;Environmental Health;Environmental Risk Factor;epidemiology study;ethylbenzene;Exposure to;Failure;Fetal Tissues;Fetus;Frequencies;Gene Expression;Gene Expression Profile;Goals;ground water;Health;Health system;high risk;High Risk Woman;Home;Human;improved;Industrialization;Infant;Infant Mortality;Inflammation;Inflammatory;inflammatory marker;Infrastructure;innovation;insight;Intervention;Leadership;Link;manufacture;Maternal-Fetal Exchange;Measurement;Measures;Mediating;Medical;Methods;metropolitan;Michigan;Minority Women;Mission;Neighborhoods;Nested Case-Control Study;novel;offspring;Outcome;Patients;Petroleum;Placenta;Pregnancy;Pregnant Women;Premature Birth;prenatal;prenatal exposure;Prevalence;prevent;Prevention;Property;prospective;Proteins;Public Health;Race;racial disparity;Recording of previous events;recruit;remediation;Research;Research Project Grants;Resources;Risk;Risk Factors;Sampling;sex;Site;social determinants;Soil;Source;Specimen;Statistical Data Interpretation;Structure;Superfund;Tetrachloroethylene;Time;Toluene;toxicant;Trichloroethylene;United States;urban setting;Urine;vapor intrusion;volatile organic compound;Vulnerable Populations;Woman;Work;Xylene

PROJECT_TITLE: Epidemiological Study of Volatile Organic Compounds and Preterm Birth in Detroit


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Infectious Diseases;Skin Cancer

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE This proposal will test the ability of CBL0137 to induce Z-DNA formation in advanced and metastatic melanoma. This effect of CBL0137 as of a ‘virus mimetic’ is predicted to activate nuclear necroptosis via the ZBP1-RIPK3- MLKL signaling cascade in melanoma TME and synergize with immunotherapy. We will therefore clinically validate an entirely new concept for making immunologically cold tumors hot with a broader reach to immunotherapy-refractory human cancers.

PI_NAMEs: ASTSATUROV, IGOR  (contact);OLSZANSKI, ANTHONY J.

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: anti-cancer;anti-tumor immune response;Automobile Driving;Binding;Biological;Biopsy;Blood specimen;Bypass;cancer clinical trial;cancer immunotherapy;Cell Nucleus;cell type;Cells;Clinical;Clinical Oncology;Clinical Trials;Combination immunotherapy;Coupled;Data;Double-Stranded RNA;experience;feasibility trial;Fibroblasts;Human;immune checkpoint blockade;Immune response;Immunity;Immunofluorescence Immunologic;immunogenic;immunogenicity;Immunologic Adjuvants;Immunologics;Immunosuppression;Immunotherapy;In Situ;Inflammatory;Inflammatory Response;Influenza;influenza infection;influenzavirus;Informatics;Innate Immune Response;insight;Interferon Type I;intravenous administration;ipilimumab;Left;Malignant - descriptor;Malignant Neoplasms;Melanoma;Melanoma patient;Melanoma Tumor;Metastatic Melanoma;Metastatic/Recurrent;mimetics;Mind;mouse model;Myeloid-derived suppressor cells;Natural Killer Cells;Neoadjuvant Therapy;Nivolumab;novel;Nuclear;Nuclear Protein;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Pre-Clinical Model;Proteins;Refractory;Resistance;response;RIPK3 gene;RNA;RNA Binding;Safety;sensor;Signal Transduction;small molecule;Solid Neoplasm;synergism;T cell infiltration;Testing;Tissue Sample;transcriptomics;translational oncology;tumor;Tumor Antigens;tumor microenvironment;tumor-immune system interactions;Validation;Viral;viral detection;Virus;Virus Diseases;Virus Replication;Work;Z-Form DNA

PROJECT_TITLE: A Phase I Proof-of-Concept Study of CBL0137 Combined with Ipilimumab and Nivolumab Therapy in Locally Advanced or Metastatic Melanoma


NIH_SPENDING_CATS: Social Determinants of Health

PHR: Project Narrative The Center for Leadership in Environmental Awareness and Research (CLEAR) has built an integrated, transdisciplinary framework, rooted in advanced techniques in environmental engineering and biomedical research, to address human exposures to volatile organic compounds (VOCs) and health risks in urban areas. Research findings on (a) the relationship between VOC exposure and human health risks—for preterm birth and associated adverse health outcomes in particular—combined with (b) new methods and technologies to assess and reduce those health risks, and (c) a new understanding of related biological systems, will contribute to improved public health interventions. CLEAR research is expected to have a direct impact on affected communities, stakeholders, and the agencies responsible for Superfund site management and the reduction of environmental VOC exposure. The Administrative Core is the integrative hub for CLEAR that provides experienced leadership, business management, structures for communication and coordination among CLEAR projects and cores, processes for research translation to stakeholders, and mechanisms for evaluation and adjustment of Center activities.

PI_NAMEs: MILLER, CAROL JEAN (contact)

PROJECT_TERMS: Address;Advisory Committees;Affect;Annual Reports;Awareness;Benchmarking;biological systems;Biomedical Research;Birth;Birth Rate;Businesses;career development;Cities;cohesion;cohort;commercialization;Communication;Communities;community engagement;community partners;dashboard;Data;Decision Making;Dedications;design;digital platform;Doctor of Philosophy;economic impact;Education;Educational workshop;Engineering;Ensure;Environmental Engineering technology;Environmental Exposure;Environmental Health;environmental justice;Environmental Science;Etiology;Evaluation;Event;Exhibits;experience;exposed human population;Exposure to;Fostering;General Population;Goals;Government;Government Agencies;ground water;Health;Human;Human Development;Human Resources;improved;Industrialization;Information Centers;innovation;insight;Institution;Intellectual Property;investigator-initiated translational research;Justice;Laws;Leadership;Location;Marketing;meetings;member;Methods;migration;Mission;Multimedia;National Institute of Environmental Health Sciences;offspring;operation;Outcome;Paper;Performance;Physicians;Physiologic pulse;Policies;Policy Maker;Premature Birth;Process;programs;Progress Reports;Property;Public Health;public health intervention;Publications;remediation;Reproductive Health;Research;Research Activity;Research Project Grants;Resources;Risk;Science;Scientist;Self-Examination;Series;Signal Recognition Particle;Soil;stem;Structure;success;Superfund;superfund site;symposium;Techniques;technological innovation;Technology;technology development;translational approach;translational engagement;Translational Research;Universities;urban area;vapor intrusion;Visualization;volatile organic compound;Xenobiotic Metabolism

PROJECT_TITLE: Administrative Core