NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Lymphatic Research;Lymphedema;Obesity

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Despite a growing awareness of lipedema as a distinct clinical entity from obesity and lymphedema, fundamental gaps persist in our knowledge regarding both disease mechanisms and efficacy of promising treatments. The overall goal of this work is to address clinical unmet needs for patients with lipedema using advanced magnetic resonance imaging methods of vascular and molecular dysfunction, in sequence with portable clinical measures of adiposity and edema. Findings are intended to determine modalities appropriate for lipedema screening, demonstrate effects of lymphatic stimulation on symptoms of lipedema, and advance our understanding of the circulatory mechanisms involved in lipedema.

PI_NAMEs: CRESCENZI, RACHELLE L (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Address;Adipose tissue;Affect;Angiography;arm;Awareness;Blood;Blood Circulation;Blood flow;Blood Flow Velocity;Blood Vessels;Body fat;Body mass index;case control;Characteristics;Clinical;Clinical Trials;comparison control;Data;Deposition;design;Diagnosis;diagnostic screening;Diet;Disease;Edema;evidence base;Exercise;Fatty acid glycerol esters;Female;Foundations;Functional disorder;Future;Goals;Image;imaging biomarker;Imaging Device;imaging modality;improved;Inflammatory;inflammatory marker;Investigation;Knowledge;Leg;Limb structure;Lipedema;Lower Extremity;lymph flow;Lymphangiography;Lymphatic;lymphatic circulation;lymphatic imaging;lymphatic insufficiency;lymphatic vessel;Lymphedema;Magnetic Resonance Imaging;Manuals;Measures;Medicine;Modality;Molecular;Morbidity - disease rate;multimodality;novel;Obesity;obesity treatment;Pain;Pain Measurement;Pathogenesis;Pathologic;Patients;Perfusion;Pharmacologic Substance;Phenotype;Physical therapy;Physiology;portability;psychological distress;Quality of life;Radiology Specialty;Refractory;Reporting;Research;Research Personnel;screening;secondary lymphedema;Sensitivity and Specificity;Skin;Sodium;subcutaneous;symptomatology;Symptoms;System;Techniques;Technology;Testing;Time;Tissues;tool;ultrasound;Upper Extremity;Vascular Diseases;Visualization;volunteer;Water;whole body imaging;Woman;Work

PROJECT_TITLE: Visualizing vascular mechanisms of lipedema

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Dissemination and Implementation Research;Health Services;Hematology;Patient Safety;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: MEMPHIS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: PROJECT NARRATIVE Commonly applied methods to measure and analyze multimorbidity fail to provide adequate context and technical support from which to design, evaluate, and implement multilevel clinically-relevant interventions as indicated by the recently announced PAR-20-179 (Advancing Research to Develop Improved Measures and Methods for Understanding Multimorbidity). To address this gap, we propose to build on our prior novel work designing the cumulative burden measure of multimorbidity and: (1) develop patient-level personalized risk- prediction, based on predefined risk factors and “burden weights,” a condition-specific, patient-derived health- related quality of life metric designed to incorporate patient perspectives; (2) create visualization tools to facilitate sharing of cumulative burden data, from any cohort, broadly across different stakeholder audiences; (3) study, for the first time, chronic multimorbidity in a highly vulnerable population of pediatric and adult sickle cell patients while simultaneously examining the barriers and enablers that impact effective implementation of the cumulative burden measures in an unrelated, non-cancer clinical population. We anticipate our work will yield a suite of visualization templates and modular applied method resources in order to support implementation within a diverse number of cohort studies with the ultimate goal of assisting health system planning and improving understanding by clinicians, researchers, advocacy groups, and policymakers about the growing problem of multimorbidity affecting nearly every sub-group of society.

PI_NAMEs: BHAKTA, NICKHILL HITESH (contact);YASUI, YUTAKA

PROGRAM_OFFICER_NAME: SMITH, ASHLEY

PROJECT_TERMS: Accounting;Address;Adoption;Adult;Advocacy;Affect;Age;analytical tool;Caring;Catalogs;Child;Childhood;childhood cancer survivor;Childhood Cancer Treatment;Chronic;Clinical;clinical care;clinical decision-making;Clinical Oncology;clinically relevant;cohort;Cohort Studies;comorbidity;Complex;Consolidated Framework for Implementation Research;Data;design;Dissemination and Implementation;Ensure;Epidemiologic Methods;Epidemiology;epidemiology study;Etiology;Event;Frequencies;Future;Goals;Health;Health Personnel;Health Policy;health related quality of life;Health Services;Health system plans;High Prevalence;implementation science;improved;Incidence;Individual;individual patient;innovation;insight;interest;Intervention;Life;Life Cycle Stages;Long Term Survivorship;Measures;Methodology;Methods;Morbidity - disease rate;multidisciplinary;multiple chronic conditions;novel;Online Systems;Outcome;Outcomes Research;Output;Pathology;Patient Outcomes Assessments;Patients;Pattern;Pediatric cohort;Personal Satisfaction;personalized predictions;personalized risk prediction;Policies;Policy Maker;Population;Prevalence;Prevention;Process;prospective;Publishing;Recurrence;Research;Research Design;Research Personnel;Research Priority;research study;Resources;response;Risk;Risk Factors;risk prediction;Saint Jude Children's Research Hospital;severe mental illness;Severities;Sickle Cell;Sickle Cell Anemia;Societies;software development;Subgroup;Testing;Therapeutic;Time;tool;treatment planning;Variant;Visual;Visualization;Visualization software;Vulnerable Populations;Weight;Work

PROJECT_TITLE: Measuring Lifelong Multimorbidity with Patient Perspectives: Implementing and Visualizing the Cumulative Burden Methodology Across Cohorts

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Neurosciences;Substance Misuse;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Reanalyzing data from some of the seminal studies linking a low level of response (LR) to alcohol to future alcohol-related problems, this R21/R33 Phased Innovation project aims to: 1) explore relationships of LR to acute and chronic alcohol tolerance; and 2) elucidate some of the functional brain networks underlying one's sensitivity and acute tolerance to alcohol. Building on the experienced investigative team's prior research, and incorporating insights from Newlin and Thomson's “Differentiator” and King's “Modified Differentiator” models, we will use neuroendocrine and ethanol-functional magnetic resonance imaging (fMRI) approaches to explore the hypothesis that alcohol sensitivity involves both the drug's rewarding and stress-provoking properties which might differ between the sexes. The successful completion of this project should lead to more refined sex- specific hypotheses regarding these functional brain networks, and to improved neuroimaging-based quantitative models that better explain the linkages among alcohol sensitivity, tolerance, and the development of alcohol use disorders.

PI_NAMEs: ANTHENELLI, ROBERT M (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Acute;Adrenal Glands;Affect;Affective;alcohol effect;alcohol related problem;alcohol response;alcohol sensitivity;alcohol use disorder;Alcohols;Amygdaloid structure;Ataxia;Blood alcohol level measurement;Brain;Brain region;breath alcohol measurement;career;Chronic;Corticotropin;Data;Data Set;Development;Diagnostic;Dose;drinking;drug reward;emerging adulthood;emotion regulation;Emotional;Emotional Stress;Endocrine;Ethanol;Exhibits;experience;experimental study;Face;falls;Feasibility Studies;feasibility trial;Female;Functional Magnetic Resonance Imaging;Future;Goals;hedonic;Hormonal;Hormones;Human;Hydrocortisone;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;imaging approach;improved;Individual;individual response;innovation;insight;Interview;Laboratories;Laboratory Study;lens;Life;Limb structure;Link;male;Measures;men;Modeling;neurobiological mechanism;neuroimaging;Neurosecretory Systems;Pathway interactions;Patient Self-Report;Pattern;Persons;Pharmaceutical Preparations;Phase;pilot test;Pituitary Gland;Pituitary-Adrenal System;Placebos;Plasma;Prefrontal Cortex;Procedures;Property;Research;response;Rest;reward processing;Rewards;secondary analysis;sedative;segregation;Seminal;Series;sex;Sex Differences;Stress;stress reactivity;Structure;Testing;Trier Social Stress Test;Woman;Work

PROJECT_TITLE: Exploring Potential Sex Differences In Neurobiological Mechanisms of Alcohol Sensitivity and Tolerance

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Lung;Pediatric;Physical Activity;Prevention;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: PROJECT NARRATIVE Although the Fontan surgical procedure, which reroutes blood from the heart to the lungs, has greatly improved survival in children born with “single ventricle” congenital heart defects, these patients remain at risk for significant organ dysfunction and premature death. The proposed research focuses on using magnetic resonance imaging and computational models to characterize the novel role of blood viscosity in the Fontan circulation, with the long-term goals of developing sensitive tools to screen for Fontan failure and therapies to improve care in this growing population of chronically ill patients. This project is relevant to public health and in line with the NHLBI’s mission as it will promote the prevention and treatment of heart disease, so that people with the Fontan circulation can live longer and have more fulfilling lives.

PI_NAMEs: CHENG, ANDREW L (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: 4D MRI;Accounting;Affect;aged;Behavior;Biomechanics;Blood;Blood flow;Blood Vessels;Blood Viscosity;California;Cardiac;Cardiac Catheterization Procedures;cardiac magnetic resonance imaging;Cardiac Output;Cardiopulmonary;career development;Caring;Cessation of life;Child;Childhood;Chronically Ill;Circulation;Clinical;Clinical Markers;cohort;Complex;Computer Models;congenital heart abnormality;Congenital Heart Defects;Cyanosis;Data;Development;Development Plans;Diagnosis;Educational Curriculum;Electrical Engineering;Engineering;ethnic diversity;Exercise;exercise capacity;Exercise Test;experience;Face;Failure;Functional disorder;Funding;Geometry;Goals;Heart;Heart Diseases;Heart Transplantation;improved;In Vitro;in vivo;Interdisciplinary Study;Liquid substance;Liver Failure;Los Angeles;Lung;Lymphatic;Magnetic Resonance Imaging;Mentored Patient-Oriented Research Career Development Award;Mission;Modeling;mortality;multidisciplinary;National Heart, Lung, and Blood Institute;novel;Operative Surgical Procedures;Organ;Outcome;Patients;Pediatric cardiology;Pediatric cohort;Pediatric Hospitals;Performance;Persons;pharmacologic;Physicians;Physiologic pulse;Population;Predictive Value;premature;prevent;Prevention;Prognostic Marker;Property;Public Health;Publishing;Pulmonary artery structure;Research;Research Design;Research Personnel;Research Project Grants;Rest;Risk;Role;Route;Scientist;shear stress;Single ventricle congenital heart disease;statistics;Testing;Therapeutic Intervention;tool;Training;Translating;Universities;Variant;Vascular Diseases;Venous;Ventricular Dysfunction;Viscosity;Wisconsin

PROJECT_TITLE: Impact of Blood Viscosity and Vascular Compliance on Fontan Circulation Dysfunction in Children

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: BELTSVILLE

ORG_NAME: PACIFIC INSTITUTE FOR RES AND EVALUATION

ORG_STATE: MD

PHR: PROJECT NARRATIVE This study will support spatial and legal epidemiological research that will (1) summarize tribal alcohol policies across 56 tribal nations collocated in 13 US states, (2) perform qualitative and quantitative studies of the local contexts and enforcement implementation of alcohol policies across these 56 tribal nations, and (3) assess relationships of state and tribal alcohol policies to alcohol related health outcomes using hospital discharge and traffic injury data. For communities experiencing stark health inequities, the tribal alcohol policy measures developed in this project will increase capacity for policy making, provide opportunities for culturally and contextually-tailored health policy research interventions, create collaborative knowledge for multiple jurisdictions, and support jointly constructed solutions to public health problems. Results will advance methods for understanding alcohol regulation and measures of population health among communities experiencing some of the most disparate health inequities in the United States, demonstrate the utility of including community voices to enrich our empirical assessments of contextual factors associated with alcohol-related outcomes, and support community advocacy for policy change by improving understanding of policy effects on health outcomes.

PI_NAMEs: LEE, JULIET P (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: Accident and Emergency department;Address;Adopted;Advocacy;Affect;Alaska Native;Alcohol abuse;alcohol availability;Alcohol consumption;Alcohol dependence;alcohol measurement;alcohol policy information system;alcohol related problem;Alcohols;American Indian Tribe;American Indians;AODR mortality;Area;Attitude;authority;behavioral study;Charge;Communities;community advisory board;community based participatory research;community engagement;Community Health;comparative;Congresses;contextual factors;Data;design;Documentation;Economics;Effectiveness;Ensure;Epidemiologic Methods;Epidemiology;epidemiology study;evidence base;experience;Foundations;Genetic;Hand;Health;health assessment;health disparity;health inequalities;Health Policy;heterogenous data;High Prevalence;Hospitalization;Hospitals;improved;Indian reservation;Indigenous;Individual;Information Dissemination;Information Systems;Injury;insight;Intervention;Interview;Investigation;Joints;Knowledge;Law Enforcement;Laws;Legal;Literature;Low Prevalence;Measures;Methods;Modeling;National Institute on Alcohol Abuse and Alcoholism;Outcome;Police;Policies;Policy Making;Policy Research;Population;population health;Prevention approach;Prevention Research;Price;Psychology;Public Health;Public Policy;public policy on alcohol;Qualitative Research;Records;Regulation;repository;Research;Research Institute;Research Methodology;Research Personnel;Reservations;Risk;Sales;Sampling;Scientist;Site;social;social structure;spatial epidemiology;structural determinants;Surveys;tribal community;tribal health;tribal lands;tribal leader;tribal Nation;Tribes;Typology;underage drinking;United States;Universities;US State;Vehicle crash;Voice;Washington;Work;Writing

PROJECT_TITLE: Healthy Native Nations: Identifying Effective Alcohol Policies for American Indian Tribes

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research is relevant to public health in that the discovery of novel models of radiation necrosis and glioma response are expected to transform our understanding of the effects of high LET radiation and reveal novel avenues for treatment. Thus the proposed studies are relevant to the National Cancer Institute and its mission to support research to improve cancer treatment and rehabilitation.

PI_NAMEs: GROSSHANS, DAVID R (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: 3-Dimensional;Accidents;Animal Model;Apoptosis;Area;Biological;Biological Models;Brain;Brain Diseases;Brain Glioblastoma;Brain Injuries;Brain Neoplasms;brain tissue;cancer cell;cancer rehabilitation;cancer therapy;Carbon;Cell Death;cell killing;Cell Survival;cell type;Cells;Central Nervous System;Cerebrum;Cessation of life;Clinical;clinical practice;Clinical Treatment;Clinical Trials;clinically relevant;Coculture Techniques;combinatorial;Data;density;Deposition;design;Disease;disorder control;Dose;Dose Fractionation;Effectiveness;Environment;Fractionation;Glioblastoma;Glioma;Growth;Heavy Ions;Heterogeneity;High-LET Radiation;Human;human induced pluripotent stem cells;Immunocompetent;Immunotherapy;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Incidence;interest;ionization;Ions;irradiation;Knowledge;Malignant Neoplasms;Maps;Mission;Modeling;Molecular;Mus;National Cancer Institute;Necrosis;Necrosis Induction;neoplastic cell;neuroinflammation;Neurons;Normal tissue morphology;novel;novel therapeutics;Organoids;particle;particle beam;particle therapy;Pathway interactions;patient response;Patients;pharmacologic;phenomenological models;Photons;physical property;Play;postmitotic;process optimization;proton therapy;Protons;Public Health;Radiation;Radiation Dose Unit;Radiation necrosis;radiation resistance;radiation response;Radiation therapy;radioresistant;Relative Biological Effectiveness;Reporting;Research;Research Support;response;Rodent Model;Roentgen Rays;Role;Scheme;Signal Pathway;stem cells;success;Survival Rate;System;therapy development;Tissues;Toxic effect;Transgenic Animals;Treatment Efficacy;treatment planning;treatment response;tumor;Variant

PROJECT_TITLE: Determining the optimal ion and fractionation scheme for the treatment of GBM in a comprehensive human organoid model


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Recovery Support Services;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: BOZEMAN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: Project Narrative This research project uses a Community-Based Participatory Research (CBPR) framework to test the efficacy of a culturally adapted relapse prevention intervention developed collaboratively by community partners from the Fort Peck Indian Reservation in northeastern Montana and research partners from Montana State University. The Indigenous Recovery Planning intervention employs trained Fort Peck community members to deliver manualized intervention content to American Indian adults with substance use disorder (SUD). By increasing access to culturally responsive evidence-based treatment, this research aims to decrease SUD- related health disparities and improve public health outcomes for underserved Native communities locally and nationally.

PI_NAMEs: SKEWES, MONICA C (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Abstinence;Accidents;Address;Adult;Affect;Aftercare;alcohol use disorder;Alcohols;American Indian community;American Indian Population;American Indians;Area;barrier to care;Behavior Therapy;Clinical Trials;commune;Communities;community advisory board;community based participatory research;community partners;Control Groups;cultural values;culturally appropriate intervention;Data;Death Rate;design;Distress;Drug Use Disorder;effective therapy;efficacious intervention;efficacious treatment;efficacy testing;Employment;ethnic identity;ethnic minority;evidence base;Evidence based intervention;Evidence based treatment;experience;Fetal Alcohol Spectrum Disorder;follow up assessment;follow-up;frontier;Generations;Grief reaction;healing;Health;health disparity;health equity;Health Services Accessibility;Hypertension;improved;indexing;Indian reservation;Indigenous;Injury;innovation;Institutional Racism;Intervention;Intervention Trial;Interview;Knowledge;Lateral;Liver diseases;Maintenance;Manuals;Mediator;Medical;member;Methods;Montana;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Outcome Assessment;Participant;patient engagement;Persons;Pharmaceutical Preparations;Pilot Projects;post intervention;preventive intervention;primary outcome;process evaluation;prospective;protective factors;psychologic;Public Health;Quality of life;Race;racism;Random Allocation;Randomized;randomized, controlled study;Randomized, Controlled Trials;Recovery;reduced substance use;relapse prevention;relapse risk;Reporting;Research;Research Project Grants;Risk Factors;satisfaction;secondary outcome;Sioux Indians;Spirituality;standard care;Stress and Coping;Structure;substance use;Substance Use Disorder;Suicide;Testing;therapy design;Training;Trauma;trauma symptom;treatment effect;Treatment outcome;tribal member;Universities;Violence;Waiting Lists;Work

PROJECT_TITLE: Randomized Controlled Trial of Indigenous Recovery Planning for American Indians

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(55)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Stroke

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Magnetic resonance imaging (MRI) was a major advance of the 20th century in patient care, but the need for high magnetic field instrumentation limits widespread accessibility. We have made progress with low-field MRI and compute-based imaging reconstruction and interpretation approaches. We propose the deployment of a point-of-care (POC), portable and highly mobile low-field MRI solution in two independent patient care settings. This system will be used at the bedside in individual patients as a model for broader deployment into any healthcare setting.

PI_NAMEs: KIMBERLY, WILLIAM TAYLOR;ROSEN, MATTHEW SCOT;SHETH, KEVIN NAVIN (contact)

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: Acute;acute stroke;Algorithms;Ambulances;Blood;Brain Edema;Brain hemorrhage;Brain Injuries;brain magnetic resonance imaging;Cerebral hemisphere hemorrhage;Cessation of life;Characteristics;Classification;classification algorithm;Clinical;clinical care;Clinical Research;clinical translation;Collaborations;Communities;Computed Tomography Scanners;Computer Interface;Controlled Environment;cost;Critical Illness;cryogenics;Data;Data Set;Decision Making;deep learning;deep neural network;Democracy;design;Detection;Development;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic technologies;Diffusion;Emergency Medicine;Engineering;Enrollment;Environment;experience;General Hospitals;Health;health care settings;Health system;Hemorrhage;Hospitals;Hour;Human;Image;Image Analysis;image reconstruction;improved;individual patient;Industry Collaboration;industry partner;Infarction;innovation;insight;Institution;instrument;instrumentation;Ischemia;Ischemic Stroke;Liquid substance;low and middle-income countries;Machine Learning;magnetic field;Magnetic Resonance Imaging;Massachusetts;Measurement;Measures;Methodology;Methods;Modeling;Monitor;Multicenter Studies;multidisciplinary;neuroimaging;Neurological disability;novel;novel strategies;operation;Patient Care;Patients;Physiologic pulse;point of care;portability;Positioning Attribute;post stroke;Power Sources;prevent;prospective;Public Health;Radiation;reconstruction;Research;Resolution;Resources;Rural Community;Sampling;Scanning;Sensitivity and Specificity;Serial Magnetic Resonance Imaging;Source;Specialist;Specificity;standard of care;Stroke;stroke neurology;stroke patient;success;System;Tablet Computer;Techniques;technological innovation;Technology;Time;tool;Training;Translational Research;ultra high resolution;Uncertainty;virtual;Weight;X-Ray Computed Tomography

PROJECT_TITLE: Portable, Low Field Brain Magnetic Resonance Imaging (MRI) for Acute Stroke


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Pain Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE / RELEVANCE  3 sentences We propose to study the effects of the NK1 receptor antagonist, tradipitant, on gastric function and symptom improvement in patients with functional dyspepsia. We will utilize and further validate simultaneous measurements of gastric emptying and gastric accommodation utilizing a solid meal and nuclear medicine scanning technique to better understand the pathophysiology of functional dyspepsia as well as the mechanism of action of tradipitant. Further understanding of the underlying gastric physiologic changes will provide groundwork for future diagnostic and therapeutic advances in functional dyspepsia.

PI_NAMEs: WANG, XIAO JING  (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Abdomen;Abdominal Pain;Acids;Address;Affect;American;Amitriptyline;antagonist;Anti-Anxiety Agents;Anti-Cholinergics;anti-depressive agents;Antibiotics;Antral;aprepitant;Automobile Driving;care seeking;Central Nervous System;chemotherapy;clinical effect;clinical efficacy;comorbidity;Complex;Consult;cost;Development;Diagnostic;Discipline of Nuclear Medicine;Disease;Distress;Dyspepsia;early satiety;Eating;economic impact;Economics;effective therapy;Enteral Feeding;Epigastric;Escitalopram;Fasting;FDA approved;Functional disorder;Future;G-Protein-Coupled Receptors;Gastric Emptying;gastrointestinal function;gastrointestinal symptom;gastrointestinal system;Gastrointestinal tract structure;Gastroparesis;General Population;Generations;Genes;Genetic Polymorphism;genetic variant;Health;health care service utilization;Helicobacter pylori;Hypersensitivity;imaging modality;improved;indexing;Institution;Literature;Measurement;Measures;Medical;Meta-Analysis;Morbidity - disease rate;Nausea;Nausea and Vomiting;Neuromodulator;non-invasive imaging;novel;Pain;Participant;Patient Outcomes Assessments;patient tolerability;Patients;Peptides;Periodicity;Pharmaceutical Preparations;Pharmacodynamics;Pharmacogenetics;pharmacologic;Physicians;Physiological;Placebos;Population;Prevalence;Productivity;Proton Pump Inhibitors;receptor;Receptor Activation;Receptor Gene;reduce symptoms;Reporting;risk/benefit ratio;Safety;Satiation;Scanning;side effect;Solid;Stomach;Substance P;symptomatic improvement;Symptoms;Syndrome;systematic review;TAC1 gene;Tachykinin;TACR1 gene;Techniques;Therapeutic;Variant;Visceral;volunteer;Workplace

PROJECT_TITLE: Pharmacodynamics, Pharmacogenetics, Clinical Efficacy and Safety of Tradipitant for Functional Dyspepsia

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Eyes with advanced glaucomatous damage have little residual reserve and small amounts of progression can have important consequences affecting patient’s visual function and quality of life. We propose optimizing the use of longitudinal optical coherence tomography macular data to confirm and predict functional progression. The results of the proposed study will lead to the development of more effective methods for earlier detection of glaucoma progression and will allow clinicians to more aggressively treat deteriorating eyes resulting in decreased visual disability and reduced rates of blindness from glaucoma. ! !

PI_NAMEs: NOURI-MAHDAVI, KOUROS  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: advanced disease;Affect;Age;age related;Algorithm Design;Algorithms;Axon;Bayesian Analysis;Bayesian Modeling;Blindness;central visual field;Clinical;clinical application;clinical encounter;cohort;Complex;Computer software;Data;Decision Making;Detection;Deterioration;Development;Diagnostic;Disease;Disease Progression;Early Diagnosis;Enrollment;Ethnic Origin;experience;Eye;Floor;follow-up;functional loss;functional outcomes;Future;Gender;Glaucoma;Goals;high risk;Image;improved;inclusion criteria;Joints;Linear Regressions;longitudinal analysis;macula;Measurement;Measures;meetings;Methods;Modeling;Monitor;Noise;nonlinear regression;novel;Optic Disk;Optical Coherence Tomography;patient population;Patients;Pattern;Performance;Positioning Attribute;predictive modeling;Probability;prospective;Quality of life;rate of change;Reproducibility;Residual state;Retina;Retinal Ganglion Cells;retinal nerve fiber layer;Severities;Severity of illness;Signal Transduction;Software Design;software development;Structure;Structure-Activity Relationship;Testing;Thick;Time;time use;tool;Vision;Visit;Visual disability;Visual Fields

PROJECT_TITLE: Detection of Disease Progression in Advanced Glaucoma

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Childhood Injury;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Infant Mortality;Neurosciences;Palliative Care;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Unintentional Childhood Injury

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Narrative: Premature birth and congenital heart disease are two of the most common causes of sickness and death of newborns in developed countries. Both conditions are associated with brain injury and abnormal neurodevelopment. Our goal is to understand the best approach for treating heart defects to prevent brain injury and improve neurodevelopment in babies born early with heart conditions.

PI_NAMEs: MCQUILLEN, PATRICK SEAN (contact)

PROGRAM_OFFICER_NAME: EGERSON, D'ANDREA R

PROJECT_TERMS: Accounting;Address;Affect;Age;Anesthetics;Birth;Brain;brain abnormalities;Brain Injuries;brain magnetic resonance imaging;Bypass;Cardiac;cardiac repair;Categories;Chromatin;Cilia;Clinical;clinical risk;Common Ventricle;comorbidity;comparative;Complex;congenital heart abnormality;Country;critical congenital heart disease;Developed Countries;Development;Diagnosis;Diffusion;Duct (organ) structure;Equilibrium;Evaluation;experience;Genes;Genetic;genetic variant;Gestational Age;Goals;gray matter;Growth;Heart;heart defect;Image;improved;Infant;Inherited;Injury;Intervention;Knowledge;Live Birth;machine learning model;Magnetic Resonance Imaging;Measures;Molecular Abnormality;Morbidity - disease rate;Morphology;multimodality;Nature;Neonatal Mortality;neurodevelopment;Neurodevelopmental Disorder;Newborn Infant;operation;Operative Surgical Procedures;optimal treatments;Outcome;Oxygen;palliation;palliative;Palliative Surgery;Parents;Patients;Pattern;perinatal morbidity;Perioperative;personalized decision;Physiology;Positioning Attribute;Postoperative Period;Predisposition;premature;Premature Birth;Premature Infant;preterm newborn;prevent;primary outcome;repaired;Reporting;Resources;Risk;Risk Factors;sedative;Severity of illness;sex;Shunt Device;Socioeconomic Status;Source;Spectrum Analysis;Staging;Stents;Structure;surgical risk;Syndrome;Term Birth;Testing;Time;Variant;Vulnerable Populations;Weight;white matter;white matter injury

PROJECT_TITLE: Brain Injury and Dysmaturation in Newborns with Congenital Heart Disease Born Preterm

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Alzheimer’s disease and related disorders (ADRD) research represents an area of major national investment. But ADRD research faces delays and risks to internal and external validity resulting from consistent challenges to efficient and generalizable accrual. Recruitment registries are tools to address these challenges by establishing large repositories of individuals who are potentially eligible and willing to participate in research, expediting discovery. This proposal will provide researchers with critical evidence to instruct methods to diversify registries by including people from the most disadvantaged neighborhoods and addressing sample bias in these unique recruitment interventions.

PI_NAMEs: GILLEN, DANIEL L;GRILL, JOSHUA  (contact);KIND, AMY J.

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: Acceleration;Accounting;Address;Advertising;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Attitude;Bolus Infusion;Brain Diseases;Characteristics;Clinical Research;cohort;combat;Community Outreach;Computer software;Consent;cost;crowdsourcing;Data;Data Sources;Databases;deprivation;design;digital;Disease;disorder risk;Disparity;Effectiveness;Eligibility Determination;Enrollment;Ethnic Origin;Face;Facebook;General Population;improved;indexing;Individual;Institution;Interruption;Intervention;intervention effect;Investments;Methodology;Methods;Modeling;Modernization;Modification;Multilingualism;National Health and Nutrition Examination Survey;neighborhood disadvantage;Neighborhoods;novel;open source;Outcome;Participant;participant retention;Patient Recruitments;Persons;Population;Population Heterogeneity;Prevalence;Probability Samples;Procedures;Public Health;Questionnaires;Race;Randomized;recruit;Registries;repository;Research;Research Personnel;research study;Resources;retention rate;Risk;Sampling;Sampling Biases;Series;social health determinants;Subgroup;Testing;Time;tool;Uncertainty;Validity of Results;Weight;willingness;Work

PROJECT_TITLE: Recruiting and retaining participants from disadvantaged neighborhoods in registries

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-K(90)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: PROVIDENCE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative In a genetic screen, we made the unexpected discovery of a synaptic tRNA methyltransferase, TRM9L that regulates the formation and function of synapses and oxidative stress response. An emerging framework suggests a role for the dynamic regulation of tRNAs in modulating gene expression, while a growing list of links between tRNA modifying enzymes and neurological disorders underlines the importance of understanding how tRNA modification impacts neuronal function. Our proposed aims combine genetic and biochemical analyses to determine how TRM9L functions in the nervous system.

PI_NAMEs: O'CONNOR-GILES, KATHALEEN M (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Animals;Anticodon;Attenuated;Axon;Biochemical;biological adaptation to stress;Codon Nucleotides;Collaborations;Complex;Drosophila genus;Engineering;Enzymes;Epilepsy;experimental study;Family;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic;genetic analysis;Genetic Screening;Genetic study;Growth;Growth Cones;imaging study;in vivo;insight;Intellectual functioning disability;Laboratories;Learning;Link;Links List;loss of function;Memory;Messenger RNA;Methylation;Modeling;Modification;Nerve Degeneration;Nervous System;nervous system development;Nervous System Disorder;Nervous System Physiology;neural circuit;neurodevelopment;Neuronal Plasticity;Neurons;neurotransmitter release;Oxidative Stress;paralogous gene;Play;Positioning Attribute;posttranscriptional;protein expression;Proteomics;Regulation;Resistance;response;Role;spatiotemporal;Stress;Synapses;synaptic function;Synaptic plasticity;System;Testing;tool;Transcript;Transfer RNA;Translational Regulation;Translations;tRNA Methyltransferases;Uridine;Validation;Yeasts

PROJECT_TITLE: Function of TRM9L and tRNA Wobble Uridine Modification in the Nervous System

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CLEVELAND STATE UNIVERSITY

ORG_STATE: OH

PHR: Narrative Similar or identical DNA sequences along chromosomes have an impressive ability to find and interact with each other. Defects in such homologous DNA interactions may result in cell senescence, cancer, and reproductive failure. Our work will generate an assay that identifies sites of homologous DNA interactions along the entire genome of intact cells, thereby allowing diagnosis of mistakes in DNA interactions under pathological conditions.

PI_NAMEs: BOERNER, VALENTIN  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Adsorption;Alleles;Biological Assay;Biological Process;Cell Aging;Cells;Chromatin;Chromosomal Breaks;chromosome conformation capture;chromosome missegregation;Chromosome Segregation;Chromosome Structures;Chromosomes;Congenital Abnormality;Cruciform DNA;Cytology;Defect;detection assay;Development;Diagnosis;Digestion;Disease;DNA;DNA Ligation;DNA Sequence;ds-DNA;Elements;Engineering;Ensure;Excision;Failure;Foundations;Frequencies;Gene Dosage;Gene Expression;Genetic;Genetic Diseases;Genetic Recombination;Genome;Genome engineering;Genome Mappings;Genome Stability;genome-wide;Genomic Instability;Genomic Segment;Germ Lines;Glean;Goals;Haploidy;Head;Health;Hi-C;Homologous Gene;homologous recombination;improved;insight;Investigation;Ligation;Link;Malignant Neoplasms;Maps;Mediating;Meiosis;Mitotic;model organism;Molecular;Monitor;novel;Nucleotides;Pathologic;Positioning Attribute;Premature aging syndrome;Premature Birth;prevent;Proteins;prototype;Refractory;repaired;Reporter;reproductive;Resolution;Ribosomal DNA;Role;Saccharomycetales;segregation;Sexual Reproduction;Sister Chromatid;Site;Somatic Cell;Specificity;Surface;System;tool;Trans-Activators;Validation;whole genome;Work;yeast genome;Yeasts

PROJECT_TITLE: Assay for Detection of Homologous DNA Interactions

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The proposed research is relevant to public health because a better understanding of how IgE is produced and regulated is ultimately expected to increase understanding of health issues related to allergic disease, in which IgE plays a key role. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to developing fundamental knowledge that will help to reduce the burdens of human disability.

PI_NAMEs: WESEMANN, DUANE R. (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Affinity;Allergens;Allergic;Allergic Disease;Allergic inflammation;Alternative Splicing;Anaphylaxis;Anatomic Models;Antibodies;Antibody-Producing Cells;antigen binding;Antigens;Apoptosis;B-Cell Antigen Receptor;B-Lymphocytes;Basophils;Binding;Biological;Biology;Bone Marrow;Bone Marrow Aspiration;Cell Degranulation;Cell Lineage;Cell surface;Cell Surface Receptors;Cell Survival;Cells;Complex;cytokine;Data;deep sequencing;density;Development;disability;Distal;Evolution;experimental study;Food;Gene Expression Profiling;genetic manipulation;Geography;Health;Heavy-Chain Immunoglobulins;Human;Human Volunteers;Hypersensitivity;IgE;Immunity;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;Immunoglobulins;Individual;Inflammation;Inflammation Mediators;insight;Interleukin-13;Interleukin-4;Knowledge;life span;Literature;Location;manufacture;mast cell;Mediating;Membrane;Memory;Memory B-Lymphocyte;Messenger RNA;Mission;mouse model;Mus;Nature;Organ;pathogen;Pathogenesis;Patients;Pattern;Peripheral;Plants;Plasma Cells;Plasmablast;Play;Process;Production;Property;Proteins;Public Health;receptor density;Research;response;restraint;RNA Splicing;Role;Signal Transduction;Site;Source;Stimulus;Structure of germinal center of lymph node;Surface;Surface Immunoglobulins;Systemic disease;Testing;Tissues;transcriptomics;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Understanding IgE Biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(57)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative The proposed project will develop an advanced mechanical testing tool for tumor mechanics studies. Knowledge learned in this proposal provides information that will aid in developing novel diagnostic or/and treatment strategies for cancer.

PI_NAMEs: WU, MINGMING  (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;Architecture;aspirate;Atomic Force Microscopy;Behavior;Biocompatible Materials;Biological Assay;Biological Sciences;Blood Vessels;Cancer Prognosis;Cell Adhesion Molecules;Cell Culture Techniques;Cell Line;cell type;Cell-Cell Adhesion;Cells;Cessation of life;Clinical;computer program;Data Analyses;diagnostic tool;Distant;Drug Delivery Systems;E-Cadherin;engineered stem cells;Engineering;Equus caballus;experimental study;Extracellular Matrix;fabrication;Feedback;force sensor;Funding;Generations;Goals;Image;Impairment;In Vitro;in vivo;innovation;interstitial;intravital imaging;Invaded;Knowledge;Learning;Malignant - descriptor;Malignant Neoplasms;Materials Testing;Measures;Mechanics;Membrane;Methods;Microfluidics;microscopic imaging;Molecular;molecular dynamics;Neoplasm Metastasis;neoplastic cell;novel diagnostics;optical imaging;Optics;Organ;Organoids;Pathway interactions;Physiological;Play;pressure;Primary Neoplasm;Prognosis;rapid growth;Reporter;Research;response;Role;Running;Secondary to;Site;Solid;Solid Neoplasm;spheroids;Stress;Stretching;Techniques;technological innovation;Testing;Theoretical model;Time;Tissue Engineering;Tissues;tool;treatment strategy;tumor;Tumor Cell Invasion;Tumor Cell Migration;tumor progression;Tumor Promotion;vascular abnormality;Work

PROJECT_TITLE: Microfluidic platform for solid tumor mechanics and invasion

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Gene Therapy;Genetics;Human Genome;Immunotherapy

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Many forms of cancer are able to defeat T cell therapies by suppressing their growth and anti-tumor effectiveness. This research project is significant in that it will both study and develop tools to hack and reprogram the suppressive programs within therapeutic T cells. It is expected that these studies will be used to develop cell therapies that can overcome T cell dysfunction for patients with multiple types of blood cancers and solid tumors.

PI_NAMEs: JAN, MAX  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Achyrocline;Advisory Committees;Area;Biology;cancer genomics;cancer therapy;cancer type;career development;Cell Physiology;Cell Therapy;Cells;Cellular immunotherapy;Chemicals;chimeric antigen receptor;chimeric antigen receptor T cells;Chromatin Modeling;Clinical;clinical training;combat;cost;Data;Dedications;Defect;design;Development Plans;DNA Methylation;DNMT3a;DNMT3a mutation;Doctor of Philosophy;Dominant-Negative Mutation;drug action;Effectiveness;effector T cell;Engineering;Epigenetic Process;epigenome;epigenomics;experience;Functional disorder;Gene Expression Profiling;General Hospitals;Genes;genetic manipulation;Glues;Goals;Growth;Hematologic Neoplasms;Hematopoietic Neoplasms;Immune;Immunotherapy;Impairment;improved;In Vitro;in vivo;Institution;interest;K-Series Research Career Programs;Knowledge;Laboratories;Leadership;lenalidomide;loss of function;Malignant Neoplasms;Maps;Massachusetts;Mediating;Memory;Mentors;Mentorship;Methods;Mission;Molecular;Molecular Genetics;multicatalytic endopeptidase complex;mutant;Mutate;next generation;novel strategies;Outcome;overexpression;Pathology;patient response;Patients;Persons;Pharmaceutical Preparations;Physicians;polypeptide;Postdoctoral Fellow;Process;programs;protein degradation;Proteins;Records;Research Personnel;Research Project Grants;Resources;Risk;Role;Route;Schedule;Scientist;self-renewal;single cell genomics;single-cell RNA sequencing;skills;Solid;Solid Neoplasm;System;T cell response;T cell therapy;T-Lymphocyte;Testing;Therapeutic;tool;Training;Treatment Failure;Treatment outcome;tumor;tumor immunology;tumor microenvironment;Tumor Suppression;Tumor Suppressor Proteins;ubiquitin-protein ligase;Variant;Work

PROJECT_TITLE: Reprogramming the chimeric antigen receptor T cell epigenome to augment anti-tumor activity

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE In this Pathway to Independence Award, the applicant will use advanced multimodal neuroimaging and statistical techniques to elucidate the extent to which small vessel cerebrovascular disease (svCBVD) and Alzheimer’s disease (AD) pathophysiology are additive or synergistic in their effects on neurodegeneration and cognition in a community-based, middle-aged, multiethnic cohort. Specifically, the contribution of svCBVD pathophysiology, through its effect on amyloid clearance and tau phosphorylation, to AD-related neurodegeneration and memory impairment in midlife will be compared across racial/ethnic groups. Outcomes from this proposal will provide key information about the mechanisms by which svCBVD and AD pathophysiology interact at the earliest stage of their development to affect neurodegeneration and cognition that informs clinical trials on the relevant target(s) in dementia with mixed pathology that can be generalized to racially/ethnically diverse populations.

PI_NAMEs: LAO, PATRICK JORDAN (contact)

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Acceleration;Address;Affect;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Area;Autopsy;Award;Biological;Biological Markers;Black Populations;Blood Vessels;burden of illness;cardiovascular risk factor;cerebrovascular amyloid;Cerebrovascular Disorders;Cerebrovascular system;Clinical Trials;clinically relevant;Cognition;Cognitive;cohort;Communities;comorbidity;Data;Data Collection;Dementia;Development;Disease;Disease Progression;Education;ethnic difference;ethnic disparity;ethnic diversity;ethnic minority;ethnic minority population;Ethnic Origin;Ethnic Population;Evaluation;Exclusion;executive function;flexibility;follow-up;Functional disorder;Funding;Goals;High Prevalence;Hispanic Populations;Impaired cognition;Impairment;Individual;Intervention;Lead;Link;longitudinal analysis;Magnetic Resonance Imaging;Mediating;Memory;Memory impairment;Memory Loss;Mentors;middle age;Mission;multi-ethnic;multimodal neuroimaging;multimodality;National Institute on Aging;neglect;Nerve Degeneration;neuroimaging;neuron loss;Neuropsychology;Neurosciences;Not Hispanic or Latino;offspring;Outcome;Pathologic;Pathology;Pathway interactions;Phase;Population Heterogeneity;Positioning Attribute;programs;racial difference;racial disparity;racial diversity;racial minority;racial minority population;racial population;Recommendation;Regional Disease;Research;Role;skills;Socioeconomic Status;Statistical Models;statistics;tau Proteins;tau-1;Techniques;therapeutic target;Thick;Thinness;Time;Training

PROJECT_TITLE: Understanding the mechanisms linking small vessel cerebrovascular disease and Alzheimer's disease pathophysiology with neurodegeneration and cognition during midlife


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Health Services;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE California has the highest incidence and largest number of tuberculosis (TB) cases in the contiguous U.S., of which 80% are due to reactivation. These TB cases can be prevented via screening and treatment of latent tuberculosis infection (LTBI), yet, current adoption of the latent TB screening and treatment guidelines has been extremely poor. We will leverage expansive electronic health record data from two of the largest healthcare organizations in California to create and validate a new LTBI screening and treatment approach that can vastly improve identification and successful treatment of LTBI.

PI_NAMEs: TARTOF, SARA  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Address;Adoption;barrier to care;California;Caring;Cessation of life;Characteristics;clinical practice;Collaborations;Communicable Diseases;compare effectiveness;Confusion;Continuity of Patient Care;cost;culturally appropriate intervention;Data;data resource;design;Disease;Education;Educational Intervention;Effectiveness;effectiveness evaluation;effectiveness measure;efficacy trial;Electronic Health Record;electronic health record system;ethnic diversity;evidence base;experience;Guidelines;health care service organization;Healthcare;HIV;improved;Incidence;Individual;Infection Control;innovation;Institution;interest;Intervention;Interview;Joints;Knowledge;Laboratories;Machine Learning;Medical;member;Modeling;models and simulation;novel strategies;Patient Care;Patients;Performance;Persons;Pharmacy facility;point of care;Population;Population Heterogeneity;Positioning Attribute;prevent;Probability;Provider;Public Health;racial diversity;Randomized;Recording of previous events;Research;Resources;Risk;Risk Factors;screening;screening guidelines;screening program;simulation;Testing;Time;Translating;treatment adherence;treatment guidelines;treatment stratification;Tuberculosis;United States;wasting;Work;Writing

PROJECT_TITLE: A New Approach to an Old Problem: Redesigning Latent Tuberculosis Screening and Treatment

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE  Basic biological research, applied biomedical research, and biotechnology are limited by our ability to get information into and out from living systems, and to act on information inside living systems. This research will result in transformative advances in capabilities to design genetically- encoded technologies that receive, process, and transmit molecular information. Such technologies will significantly impact our ability to monitor, interface with, and program the dynamic cellular state, thereby resulting in an enhanced understanding of biological processes leading to disease and new approaches for constructing targeted molecular therapeutics.

PI_NAMEs: ENDY, DREW  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: applied biomedical research;Automation;Biological Assay;Biological Process;biological research;biological systems;Biosensor;Biotechnology;Catalytic RNA;Communities;complex biological systems;Data;Data Set;design;Disease;Elements;Engineering;Environment;Evolution;Generations;Genes;Genetic;Goals;improved;innovation;insight;interest;Libraries;Ligands;Measurement;Methods;Molecular;molecular targeted therapies;Monitor;novel;novel strategies;Organism;Pharmaceutical Preparations;Process;programs;Regulatory Element;Research;RNA;RNA Sequences;Structure;Structure-Activity Relationship;System;Technology;tool;transmission process;Untranslated RNA;Work

PROJECT_TITLE: Data-Rich Strategies for Programming Ligand-Responsive RNA Regulatory Systems

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Title: Watching cooperative interactions between base and nucleotide excision repair proteins. PI: Bennett Van Houten, PhD Project Narrative: This highly innovative project is focused on understanding how common forms of oxidative DNA damage, produced during environmental genotoxicant insult and inflammation during toxic responses, are detected and repaired in various genomic locations in living cells. This project will also explore how chromatin remodelers work with DNA repair enzymes from nucleotide (NER) and base excision repair (BER) pathways. Loss of or key alterations in BER or NER are associated with several pathophysiologies, including cancer, premature aging and neurodegeneration.

PI_NAMEs: VAN HOUTEN, BENNETT  (contact)

PROGRAM_OFFICER_NAME: HEACOCK, MICHELLE

PROJECT_TERMS: 8-hydroxyguanosine;adduct;base;Base Excision Repairs;Biochemistry;Cells;Cellular biology;Chromatin;Chromatin Structure;Complex;Data;DNA;DNA Damage;DNA glycosylase;DNA purification;DNA Repair;DNA Repair Enzymes;DNA Repair Gene;Doctor of Philosophy;Environment;environmental mutagens;Functional disorder;Gene Expression Profile;Genome;genomic locus;genomic tools;Human Genome;Individual;Inflammation;innovation;Label;Lesion;Malignant Neoplasms;methylation pattern;Molecular;Nerve Degeneration;Nuclear Extract;Nucleosomes;Nucleotide Excision Repair;Nucleotides;Optics;oxidative DNA damage;particle;Pathway interactions;Premature aging syndrome;Process;Proteins;Protocols documentation;RAD23B gene;repaired;Resolution;response;sensor;single molecule;Site;Testing;Thymine DNA Glycosylase;Time;tool;ultra high resolution;Work;XPA gene


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative The theme of the UNC Center for Environmental Health and Susceptibility (UNC-CEHS) is translating interdisciplinary research on environmental susceptibility to improve public health in North Carolina. The CEHS provides infrastructure and resources to support members in conducting interdisciplinary research and works with communities to identify environmental health susceptibilities and improve the health of North Carolinians. Our scientific and public health discoveries will be disseminated to advance national priorities in preventing environmental disease.

PI_NAMEs: TROESTER, MELISSA A. (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Advisory Committees;Ally;Applications Grants;Area;Arts;Asthma;Attention deficit hyperactivity disorder;autism spectrum disorder;base;Basic Science;Budgets;career;career development;Clinic;Clinical Data;Clinical Research;Collaborations;college;Communication;Communities;community engagement;community partners;Consultations;Core Facility;Data;data acquisition;Data Analyses;Data Science;Dentistry;developmental disease;Discipline of Nursing;Disease;Effectiveness;Ensure;environment related cancer;Environmental Exposure;Environmental Health;Evaluation;Faculty;Feedback;Fostering;Funding;Genomics;Goals;Growth and Development function;Health;health disparity;Health Sciences;Heart Diseases;Histopathology;Human;Image;improved;Individual;Infrastructure;innovation;instrumentation;Interdisciplinary Study;Knowledge;Laboratories;Leadership;Lung Diseases;Malignant Neoplasms;Mass Spectrum Analysis;Medicine;member;Mentors;method development;Methods;Mission;Modeling;Molecular;Molecular Analysis;Monitor;Morbidity - disease rate;mortality;National Institute of Environmental Health Sciences;Newsletter;next generation;North Carolina;Outcome;patient engagement;Pharmacy facility;Pilot Projects;Population Study;Predisposition;prevent;programs;Public Health;Publications;Pulmonary Heart Disease;recruit;Reporting;Research;Research Design;Research Personnel;Resources;Schools;Science;Scientist;Services;Strategic Planning;Strategic vision;symposium;Technology;Training;Translating;translational goal;Translational Research;Translations;Universities;Walking;Work

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(P0)]


PROJECT_TERMS: Advisory Committees;Analytical Chemistry;Area;Award;Basic Science;Bioinformatics;Biometry;career;career development;Clinical Medicine;Communication;Communications Media;Communities;community advisory board;community engagement;community partners;Computational Biology;Core Facility;Data Science;Development;developmental disease;Ensure;Environment;environment related cancer;Environmental Health;Epidemiology;Evaluation;experience;Genetic;Goals;Grant;Health;health science research;Health Sciences;Human;Human Resources;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;Investments;Knowledge;Leadership;leadership development;medical schools;member;Mentors;Methods;Molecular;Molecular Analysis;Monitor;multidisciplinary;next generation;North Carolina;Occupational activity of managing finances;Office of Administrative Management;operation;Pathology;Pilot Projects;Predisposition;Program Development;programs;Public Health;Public Health Schools;Publications;Pulmonary Heart Disease;recruit;Reporting;Request for Applications;Research;Research Personnel;Research Priority;Research Support;Resource Allocation;Resources;response;Schools;Science;Scientist;Services;Strategic Planning;Structure;Technology;Time;Toxicology;Training;Translating;Translational Research;translational study;Universities

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Eye Disease and Disorders of Vision;Neurosciences;Transplantation

ORG_DEPT: BIOLOGY

ORG_NAME: HERBERT H. LEHMAN COLLEGE

PHR: Project Narrative and Impact to Human Health Photoreceptor loss due to degenerative retinopathy is a leading cause of adult vision loss worldwide. Transplantation of photoreceptor precursor cells (PPCs) into the degenerative retina is an exciting strategy for replacing lost photoreceptors and restoring vision. This project aims to define and optimize the cellular mechanisms driving PPC migration into the retina for photoreceptor repopulation and vison restoration.

PI_NAMEs: REDENTI, STEPHEN M (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Adult;Automobile Driving;Binding;Bioinformatics;Biological Models;Biomedical Engineering;Biomimetics;Blindness;CD11b Antigens;cell motility;Cell secretion;Cell Surface Receptors;Cell Transplantation;Chemotaxis;Chondroitin Sulfates;comparison control;Complex;Coupled;CXCR4 gene;Data;Databases;Development;EGF gene;Epidermal Growth Factor Receptor;Exhibits;Experimental Models;Extracellular Matrix;Fibronectins;Gene Expression;Genetic Vectors;Geneticin;Geometry;glial cell-line derived neurotrophic factor;Goals;GTP-Binding Proteins;Health;Human;In Vitro;in vivo;Individual;innovation;Integrin beta Chains;Integrins;Invaded;Knock-out;Laboratories;Length;Ligands;Light;Measures;Mediating;Microfluidic Microchips;Microfluidics;Microscopy;migration;Modeling;Molecular;Muller's cell;Mus;novel;Nuclear;overexpression;PDGFRB gene;photoreceptor degeneration;Photoreceptors;Plasmids;Platelet-Derived Growth Factor;polarized cell;Population;precursor cell;Process;Proteins;receptor;Receptor Cell;receptor expression;Receptor Up-Regulation;receptor upregulation;Resistance;response;restoration;Retina;Retinal Degeneration;Retinal Diseases;Retinal Ganglion Cells;Retinal Photoreceptors;Retinitis Pigmentosa;rho;Rhodopsin;Role;sight restoration;Signal Pathway;Signal Transduction;Speed;Stains;Stimulus;Synapses;Techniques;Testing;Time;Tissues;Transfection;Transplantation;Travel;Vascular Endothelial Growth Factors;Vision;Visual Cortex;Western Blotting;whole genome;Work

PROJECT_TITLE: Modeling Photoreceptor Migration in Biomimetic Microenvironments to Optimize Transplantation


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Depression;Genetics;Human Genome;Mental Health;Mental Illness;Microbiome;Neurosciences;Nutrition;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE: Neuropsychological symptoms, such as fatigue, depressive symptoms, cognitive dysfunction, sleep problems, and pain, are among the most common, debilitating, and long-lasting side effects from cancer and its treatment and are prognostic to survival. The proposed research will examine the association between gut microbiome and neuropsychological symptoms through the role of short chain fatty acids and inflammation in the gut-brain axis among patients with head and neck cancer receiving radiotherapy. The findings may indicate new biomarkers and novel therapeutic targets for neuropsychological symptoms in cancer survivors.

PI_NAMEs: FEDIRKO, VERONIKA ;XIAO, CANHUA  (contact)

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: 16S ribosomal RNA sequencing;active method;Aftercare;Anti-Inflammatory Agents;Bacteria;Biological Factors;Biological Markers;blood-brain barrier crossing;Brain;Butyrates;Cancer Patient;Cancer Survivor;cancer therapy;chemoradiation;Clinical;Cognition;commensal bacteria;Complex;Data;depressive symptoms;Development;Dietary Fiber;Distress;dysbiosis;Eating;experience;Fatigue;fecal microbiome;Fermentation;Goals;gut bacteria;gut microbiome;gut microbiota;gut-brain axis;Head and Neck Cancer;head and neck cancer patient;High Prevalence;high risk;Homeostasis;Human;Human papilloma virus infection;immunoregulation;Impaired cognition;improved;Incidence;Individual;Inflammation;Inflammatory;Link;Longitudinal Studies;Malignant Neoplasms;Mass Fragmentography;Mediating;Mental Depression;metagenomic sequencing;microbial;microbiome;Mucositis;Mus;neuroinflammation;Neuropsychology;new therapeutic target;Oral cavity;Outcome;Pain;Pathway interactions;Patient-Focused Outcomes;Patients;Peripheral;Phase;Phenotype;Plasma;Play;Production;prognostic;protein biomarkers;Proteins;Radiation therapy;Regulation;Research;restoration;Role;side effect;Signal Pathway;Sleep;Sleep Disorders;symptom management;Symptoms;targeted treatment;therapeutic target;Time;Transcriptional Regulation;transcriptome;treatment response;trend;Validation;Volatile Fatty Acids;Work;Xerostomia

PROJECT_TITLE: The Role of the Gut Microbiome and Short Chain Fatty Acids in the Regulation of Inflammation and Neuropsychological Symptoms in Patients with Head and Neck Cancer

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health

PI_NAMEs: NICHOLS, HAZEL B (contact)

PROJECT_TERMS: Acceleration;Address;Applications Grants;Basic Science;Cancer Hospital;Clinical;Clinical Research;Collaborations;Collection;community engagement;Consultations;Core Facility;cost effective;Data;Development;developmental disease;environment related cancer;Environmental Health;epidemiology study;Fostering;Goals;Grant;Health Sciences;Human;human study;human subject;Human Subject Research;improved;Institutional Review Boards;instrumentation;Integrative Medicine;Interdisciplinary Study;Laboratories;member;Methods;Mission;Molecular Analysis;neoplasm registry;North Carolina;novel;patient engagement;patient oriented;Pilot Projects;Population;Predisposition;Price;protocol development;Protocols documentation;Public Health;public health research;Pulmonary Heart Disease;quality assurance;recruit;Reproducibility;Research;Research Personnel;research study;Research Support;Resources;Scientist;Services;Specimen;Strategic Planning;Study Subject;Technology;Translating;Translational Research;Work

PROJECT_TITLE: Integrative Health Sciences Facility Core (IHSFC)


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Men who have sex with men (MSM) are heavily burdened by HIV in the U.S., particularly young MSM and MSM of color, and many new infections occur in the context of primary or main partnerships. The overarching goal of this proposal is to improve public health by establishing the effectiveness the 2GETHER intervention package, an innovative relationship education and HIV prevention program for both single and partnered MSM, in a Hybrid Type I Effectiveness-Implementation Trial design.

PI_NAMEs: NEWCOMB, MICHAEL E (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: acceptability and feasibility;Affect;Age;Agreement;AIDS prevention;Behavior;Behavioral;Black race;Characteristics;cisgender;clinical decision-making;Communication;condomless anal sex;condoms;conflict resolution;cost;Cost Analysis;cost effective;cost estimate;Coupled;Couples;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;effectiveness/implementation trial;eHealth;Elements;Enrollment;Ethnic Origin;evidence base;Exclusion;experience;follow-up;Funding;future implementation;Goals;Health;high risk;HIV;HIV Infections;HIV risk;HIV Seronegativity;Human immunodeficiency virus test;Hybrids;implementation barriers;implementation determinants;implementation outcomes;implementation strategy;improved;Incidence;Individual;Infection;innovation;interest;Intervention;Interview;Latinx;male couples;Measures;men of color;men who have sex with men;Methods;older men;Outcome;Participant;Personal Satisfaction;pilot trial;Population;post intervention;pre-exposure prophylaxis;preference;Prevention;Prevention program;Prevention strategy;Preventive;Preventive service;program costs;programs;Public Health;Race;randomized trial;Randomized, Controlled Trials;recruit;Rectum;Research;Research Methodology;Risk;Risk Behaviors;rural area;rurality;Safety;Sampling;secondary outcome;Services;skills;Subgroup;Testing;transgender;transgender men;treatment arm;treatment effect;trial design;Underserved Population;United States;United States National Institutes of Health;uptake;videoconference;young men who have sex with men

PROJECT_TITLE: Effectiveness of Relationship Education for Reducing HIV Incidence in Men Who Have Sex with Men


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative The proposed research is relevant to public health because a greater understanding of plasticity after central vision loss can inform new therapies for treating low vision and has potential to benefit millions of individuals suffering from low vision. The treatment of low vision is particularly relevant to the mission of the NEI to support research on visual disorders, mechanisms of visual function and preservation of sight. The comparison of dif- ferent training and outcome factors is in line with the NIMH RDOC framework and studies in an aging popula- tion are consistent with the mission of the NIA.

PI_NAMEs: SEITZ, AARON R;TURK-BROWNE, NICHOLAS BENJAMIN;VISSCHER, KRISTINA  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Address;Adult;Affect;aging population;Attention;Behavior;Behavioral;behavioral outcome;behavioral plasticity;Biological Models;Blindness;Brain;Central Scotomas;cognitive control;Compensation;Complex;Data Set;data sharing;Discrimination;experience;extrastriate visual cortex;Eye;Eye Movements;Face;gaze;improved;Individual;Individual Differences;innovation;Investigation;Knowledge;Learning;learning outcome;lens;Literature;macula;Macular degeneration;Measures;Methods;Mission;Modeling;Modification;National Institute of Mental Health;neural;Neuronal Plasticity;novel strategies;novel therapeutics;Outcome;Patients;Pattern;Perceptual learning;Performance;Peripheral;Persons;Photoreceptors;Population;preservation;Process;Psychophysics;Public Health;Reading;Recovery;Rehabilitation therapy;Research;Research Design;Research Project Summaries;Research Support;Rest;Sampling;Scotoma;Sensory;spatial integration;Structure;System;Testing;Training;Translating;Vision;Vision Disorders;Visual;Visual Cortex;Visual impairment;visual processing;Work

PROJECT_TITLE: Characterization of Multiple Factors in Training and Plasticity in Central Vision Loss


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Data Science;Genetics;Human Genome

PI_NAMEs: LU, KUN  (contact)

PROJECT_TERMS: Address;analytical method;Applications Grants;Area;Award;Bioinformatics;Biometry;Clinical;Collaborations;Communities;community engagement;Competence;Conceptions;Core Facility;Data;data acquisition;Data Analyses;data analysis pipeline;Data Analytics;Data Collection;Data Science;developmental disease;Education and Outreach;educational atmosphere;Educational workshop;Ensure;environment related cancer;Environmental Health;Faculty;Genomics;Grant;Health Sciences;Human Resources;Human Subject Research;improved;Infrastructure;innovation;instrumentation;Interdisciplinary Study;Investigation;Laboratories;Lead;lectures;Medicine;member;method development;Methods;Molecular;Molecular Analysis;Neurodevelopmental Disorder;North Carolina;novel;outreach;Pathology;Pilot Projects;population based;Predisposition;programs;Public Health;Pulmonary Heart Disease;Qualifying;Research;Research Design;Research Personnel;Sample Size;Science;Services;Statistical Methods;symposium;Technology;Training;Translating;Translational Research;Translations;Update;user-friendly;Work

PROJECT_TITLE: Molecular Analysis and Statistical Support Facility Core (MASS)


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: GRAY, KATHLEEN M (contact)

PROJECT_TERMS: 6 year old;Adolescent;Advisory Committees;Affect;African American;Age;Asthma;Awareness;Child;Client;Communication;Communities;community engagement;Community Health Education;community partners;Decision Making;design;Development;Disparity;Education;Educational workshop;Elements;Emergency department visit;Ensure;Environmental Exposure;Environmental Health;Ethnic Population;Exposure to;Fellowship;Fostering;Gender;Goals;Health;health disparity;Health Educators;Health Hazards;health literacy;Health Professional;health science research;Home;Hospitalization;Housing;improved;Income;infrastructure development;Instruction;Interdisciplinary Study;K-12 Faculty;Lead Poisoning;learning engagement;Low Income Population;Malignant Neoplasms;meetings;member;Minority;mortality;North Carolina;Outcome;outreach;Persons;Population;Positioning Attribute;Predisposition;Prevalence;programs;public education;Public Health;Public Health Professional Education;Race;racial population;Research;Research Personnel;resilience;Risk;Science;science teacher;Scientist;skills;Social Environment;symposium;teacher;Trainers Training;Training;Translating;translational goal;Vulnerable Populations;webinar;Work

PROJECT_TITLE: Community Engagement Core (CEC)


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Gene Therapy;Genetics;Human Genome;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Solid and blood tumors are known to escape from and develop resistance to therapies, which renders therapies ineffective and leads to tumor progression. In this project, I propose to determine the mechanism of glioma escape from epidermal growth factor variant three (EGFRviii) targeted chimeric antigen receptor (CAR) T cell therapy and to design and test novel combination therapy strategies to prevent escape from and resistance to CAR T cells. The goal of this project is to provide better combination therapy strategies for use in patients based on mutations observed in tumor escaped cells in patients with glioma and other solid tumors.

PI_NAMEs: SWANSON, JACK H (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Acute Lymphocytic Leukemia;Adult;Antigen Targeting;Antigens;Apolipoproteins B;Bioinformatics;Blood;Brain;CAR T cell therapy;CD19 gene;cell killing;Cell Line;Cells;Central Nervous System;chemotherapy;Child;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Trials;combat;Combined Modality Therapy;Cytidine Deaminase;Data;Data Analyses;Deletion Mutation;design;DNA Sequence Alteration;Down-Regulation;engineered T cells;Enzymes;Epidermal Growth Factor;Epidermal Growth Factor Receptor;epidermal growth factor receptor VIII;experimental study;Family;FDA approved;Frameshift Mutation;Gene Expression;Gene Mutation;Genes;Genetic Transcription;genome sequencing;Genomics;Glioma;Global Change;Goals;Grant;Growth Factor;Hematologic Neoplasms;Hematopoietic Neoplasms;Human;Immune;Immunocompetent;immunodeficiency;Immunotherapeutic agent;Immunotherapy;In complete remission;In Vitro;in vivo;in vivo Model;Induced Mutation;ineffective therapies;Intrinsic factor;knock-down;Laboratories;large cell Diffuse non-Hodgkin's lymphoma;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Melanoma;Messenger RNA;Modeling;mouse model;Multiple Myeloma;Mus;mutant;Mutation;neoantigens;neoplastic cell;Neuroglia;novel;oncolytic Vesicular Stomatitis Virus;oncolytic virotherapy;Operative Surgical Procedures;Pathway interactions;Patients;polypeptide;pressure;prevent;Prognosis;Protocols documentation;Radiation therapy;rational design;receptor;Recurrence;Refractory;Relapse;Reproducibility;Research;Resistance;Resistance development;resistance mechanism;response;Solid;Solid Neoplasm;subcutaneous;Surface Antigens;T cell therapy;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapy design;therapy resistant;transcriptome sequencing;transcriptomics;tumor;Tumor Escape;tumor progression;Variant;Vesicular stomatitis Indiana virus;Virus Diseases;whole genome;Xenograft procedure

PROJECT_TITLE: Defining Antigen-Dependent and Antigen-Independent Mechanisms for EGFRviii-Expressing Tumor Escape From Therapy


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: WORCESTER

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative Early life immune system activity needs to be tightly regulated to prevent organismal developmental abnormalities. A better understanding of the origin and development of immune cells in early life has important clinical implications, especially in providing novel insights into how child-specific diseases arise. We plan to generate a high resolution atlas of skin immune cells of children, which will greatly accelerate progress towards determining how early life immune system develops and identify genetic regulatory networks that are relatively fragile, and often contribute to disease susceptibility.

PI_NAMEs: KANG, JOONSOO  (contact);RASHIGHI, MEHDI ;REBOLDI, ANDREA

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: 1 year old;3-Dimensional;Acceleration;Adipose tissue;Adult;age related;Animals;Antibiotics;Atlases;autoinflammatory diseases;Birth;Body mass index;brain tissue;Calibration;Catalogs;Cell Differentiation process;Cell Lineage;cell type;Cells;Censuses;Characteristics;Child;Childhood;Cholesterol;Clinical;Colitis;Couples;cytokine;Data;Dermal;Development;Diet;Diet Habits;dietary;Dietary Cholesterol;Disease;Disease susceptibility;Dose;dysbiosis;Ecology;Environmental Risk Factor;Epithelial Cells;Epithelium;Equilibrium;Etiology;Event;Fetus;Fibroblasts;First Pregnancy Trimester;fitness;flexibility;Fortification;G-Protein-Coupled Receptors;gene network;gene regulatory network;Generations;Genetic;genetic manipulation;Genetic Polymorphism;genome-wide;Host Defense;Human;IL17 gene;Immune;Immune response;Immune system;Immunity;infancy;Infant;Infection;Inflammatory;Inflammatory Response;innovation;insight;Insulin-Dependent Diabetes Mellitus;intercellular communication;interleukin-22;keratinocyte;Knowledge;Learning;Life;Link;Lymphocyte;Lymphocyte Function;Lymphocyte Subset;Lymphoid;Lymphoid Cell;Lymphoid Tissue;Maps;Maternal antibody;Mediating;Metabolic;Metabolic dysfunction;Methods;microorganism;Modeling;Molecular;Mus;Mycoses;Neonatal;neonatal human;neonatal immune system;neonate;Nerve Growth Factors;Neutrophil Infiltration;Normal Cell;novel;Nutritional;Obesity;Organ;Organogenesis;Organoids;Participant;pathogen;Patients;Pattern;Perinatal;Predisposition;Pregnancy;prevent;Production;programs;Proteome;Psoriasis;receptor;Receptor Signaling;reconstitution;Recording of previous events;recruit;Regulation;repaired;Resolution;response;Sampling;sensor;sensory mechanism;Sentinel;Severity of illness;single cell analysis;Skin;Skin Tissue;Structure of parenchyma of lung;Systems Development;T-Lymphocyte;Teenagers;Testing;Thymus Gland;Tissue Sample;Tissues;Toll-like receptors;transcriptome;transcriptomics;Vegetarian diet

PROJECT_TITLE: Parsing cholesterol metabolite regulation of skin immunocytes in children to identify archetypes of human neonatal immune system


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: The proposed research will facilitate a better understanding of how specific types of DNA mutations can increase or decrease in abundance through inheritance, human development, and human aging. Such understanding may lead to novel ways to treat individuals carrying certain disease-causing mutations.

PI_NAMEs: BRYNJARSDOTTIR, JENNY ;LAFRAMBOISE, THOMAS LOUIS (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: Address;Age;Aging;aging process;Algorithms;Alleles;autism spectrum disorder;base;Bayesian Modeling;Benign;biomedical informatics;Biotechnology;Blindness;Cell Nucleus;Cells;Characteristics;ChIP-seq;Chromosomes;clinically relevant;Complex;computational platform;computer infrastructure;Computer software;Data;Data Analyses;Data Set;Data Sources;Development;Diabetes Mellitus;Disease;disease phenotype;disease-causing mutation;disorder risk;DNA;DNA Sequence Alteration;Ensure;exome;experience;experimental study;flexibility;Generations;Genes;Genetic;Genetic Anticipation;genetic variant;Genome;genomic data;Genomics;Germ Lines;Goals;Haplotypes;Health;heteroplasmy;Human;Human Development;human disease;Human Genome;human genomics;In Vitro;in vivo;Individual;insight;Language;large datasets;Liquid substance;Malignant Neoplasms;Medical;Methodology;Methods;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial dysfunction;mitochondrial genome;Modeling;Modernization;Mothers;Mutation;Nature;next generation sequencing;novel;novel strategies;Nuclear;Nucleotides;offspring;Organ;Pathogenicity;Phenotype;portability;Positioning Attribute;Process;Property;Proteins;Publishing;Research;Research Personnel;Resolution;Risk;Risk Assessment;Role;Statistical Computing;Statistical Models;Stroke;System;Techniques;Testing;Time;Tissues;tool;transcriptome;tumor heterogeneity;Validation;Variant;Work

PROJECT_TITLE: Tools and Data for Bayesian Modeling of Mitochondrial Genome Dynamics in Human Disease

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: RICHMOND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: A shortage exists of MD and PhD scientific researchers equipped to develop new treatments for cardiovascular disease, the most common cause of morbidity and mortality both internationally and within the United States. Over the last 15 years, Virginia Commonwealth University, through the Pauley Heart Center, has created a high-quality research environment with federally funded, multi-disciplinary (involving collaborations among 7 institutional departments), translational (involving pursuit of fundamental discoveries that impact meaningful health outcomes) research projects conducive to training and mentoring young investigators. We now propose to further expand this academic environment to train post-doctoral professionals and clinician scientists desirous of an academic career in translational cardiovascular research – thereby helping to address the shortage of well-trained multi-disciplinary translational academic investigators needed in this area of high public health impact.

PI_NAMEs: HUNDLEY, WILLIAM GREGORY (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TITLE: Multi-Disciplinary Training Program in Translational Cardiovascular Research

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: ENGEL, STEPHANIE  (contact)

PROJECT_TERMS: Achievement;Advisory Committees;Area;Award;Budgets;Clinic;Collaborations;Communities;community engagement;community partners;Consult;Consultations;Core Facility;County;design;Development;developmental disease;Discipline;Eligibility Determination;environment related cancer;Environmental Health;Evaluation;Expenditure;experience;Extramural Activities;Faculty;Feedback;Floods;Foundations;Funding;Goals;Grant;Health;Health Sciences;Human Resources;human subject;Human Subject Research;improved;Incentives;Incubators;innovation;Interdisciplinary Study;interest;Investigation;Investments;Joints;member;Mentorship;Mission;Molecular Analysis;Monitor;National Institute of Environmental Health Sciences;North Carolina;novel;Outcome;outreach;Phase;Pilot Projects;Postdoctoral Fellow;Predisposition;professor;programs;Public Health;Publications;Publishing;Pulmonary Heart Disease;Research;research data dissemination;Research Personnel;Resources;respiratory health;response;Science;Series;Signal Recognition Particle;statistics;stem;success;Superfund;symposium;Translating;translational impact;Translational Research;United States National Institutes of Health;vaping;Walking;Work

PROJECT_TITLE: Pilot Project Program


NIH_SPENDING_CATS: Infectious Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: TUCSON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: RELEVANCE (See instructions): Despite advances in diagnostics and therapeutics, Human cytomegalovirus remains a major life-threatening complication following solid organ or stem cell transplantation and in people who are immune compromised. The goal of our work is to elucidate the molecular mechanisms by which human cytomegalovirus (HCMV) regulates cellular stress pathways to control entry into and exit from latency.

PI_NAMEs: GOODRUM, FELICIA D (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: ABCC1 gene;Address;apolipoprotein E receptor 2;ATF6 gene;Automobile Driving;biological adaptation to stress;CD34 gene;Cell surface;Cell Surface Proteins;Cells;Cellular Stress;Charge;Chemicals;Cholesterol;Cholesterol Homeostasis;Complication;Cytomegalovirus;Cytomegalovirus Infections;Defective Viruses;Diagnostic;DNA biosynthesis;Down-Regulation;endoplasmic reticulum stress;Engineering;Environment;Epidermal Growth Factor Receptor;Fatty Acids;Gene Expression;Genes;Glycoproteins;Goals;Hematopoietic;hematopoietic differentiation;Hematopoietic stem cells;Human;human embryonic stem cell;Immune;Infection;inhibitor;insight;Instruction;Integration Host Factors;knock-down;latent infection;Libraries;Life;Link;lipid biosynthesis;Lipids;Liver X Receptor;Low Density Lipoprotein Receptor;Maintenance;Maps;Mediating;Metabolism;Molecular;mutant;Myelogenous;novel;Organ;Pathway interactions;Persons;prevent;Proteins;proteostasis;reactivation from latency;recombinant virus;Regulation;response;Role;Signal Pathway;small hairpin RNA;Solid;Stem cell transplant;Sterols;Stress;Therapeutic;therapeutic target;trafficking;Tumor Necrosis Factor Receptor;ubiquitin-protein ligase;valosin-containing protein;Very Long Chain Fatty Acid;Viral;Viral Genes;Viral Proteins;Virus;Virus Diseases;virus host interaction;Virus Latency;Work

PROJECT_TITLE: Mechanisms of Human Cytomegalovirus Latency in Primary Human Hematopoietic Cells

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Human Genome;Liver Disease;Precision Medicine;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project Narrative: The lack of approved drugs for treatment of MAFLD is due to the heterogenous pathology of disease progression and the limitation that animal models do not fully recapitulate the human disease. The use of a combined QSP and iPSC-derived MPS experimental platform to examine mechanistic detail of key disease- related genetic variants and to use for testing predicted drugs serves as a starting point to identify optimized therapeutics that will advance the approach to MAFLD drug discovery. The more detailed analysis of the best drugs and drug combinations in an optimized biomimetic model will refine the selection of drugs/combinations for select patient cohorts.

PI_NAMEs: MIEDEL, MARK T. (contact);SOTO-GUTIERREZ, ALEJANDRO

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Acids;Address;Animal Model;Biochemical;Biological Process;Biomimetics;Cell Differentiation process;cell type;Cells;clinical development;clinically relevant;cohort;Computer Analysis;Data;Disease;disease phenotype;Disease Progression;Disease susceptibility;disorder risk;Dose;Drug Combinations;drug discovery;Drug Industry;drug repurposing;Drug Targeting;drug testing;fatty acid metabolism;Fatty Acids;fatty liver disease;Fibrosis;Functional disorder;Genetic;genetic variant;genome editing;genome wide association study;Genomics;Goals;hepatic acinus structure;Hepatocyte;Heterogeneity;high risk;Human;human disease;human induced pluripotent stem cells;Individual;individual patient;induced pluripotent stem cell;Inflammation;insight;Investments;Link;Liver;liver function;Metabolic dysfunction;metabolic-associated fatty liver disease;metabolomics;microphysiology system;Mitochondria;Modeling;Molecular Target;Monitor;Mutation;Names;non-alcoholic fatty liver disease;novel;Outcome;Pathology;Pathway interactions;Patient Selection;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacology;Pharmacotherapy;Phenotype;Pioglitazone;pre-clinical;precision medicine;protective allele;protective effect;Public Health;response;Risk;Risk Factors;risk variant;Role;successful intervention;System;Testing;Therapeutic;Time;transcription factor;transcriptome sequencing;treatment optimization;Variant;Vascularization

PROJECT_TITLE: Implementing A QSP Platform to Predict and Test Drugs for Metabolic Associated Fatty Liver Disease Genetic Variants in an iPSC-cell Based Human Biomimetic Liver Microphysiology System

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The T-cell lymphomas are aggressive and often chemotherapy resistant lymphomas that are associated with dismal outcomes. As novel therapeutic strategies are needed, we will investigate the role of Notch ligands, and the stromal cells that provide them, as oncogenic drivers and novel therapeutic targets in these lymphomas.

PI_NAMEs: MAILLARD, IVAN ;WILCOX, RYAN A (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acute;Address;Antibodies;ATAC-seq;Automobile Driving;biobank;Cell Communication;Cells;Chemoresistance;ChIP-seq;clinical translation;cohort;Computing Methodologies;Cryopreservation;Data;Data Set;Development;Diagnosis;Disease;Extranodal;Gene Expression;Genetic;genetic approach;Genetic Transcription;Genetically Engineered Mouse;genome-wide;Growth;Heterogeneity;Human;imaging modality;improved;in vivo;Individual;Ligands;Lymphoid Tissue;Lymphoma;Malignant - descriptor;Malignant Neoplasms;Mature T-Lymphocyte;Mediating;Methods;Modeling;Molecular;Mus;neoplastic cell;new therapeutic target;Non-Malignant;notch protein;novel therapeutic intervention;Oncogenic;Outcome;Pathogenesis;Patients;Peripheral;pharmacologic;Physiological;Play;primary lymphoid organ;programs;Proliferating;receptor;Recurrence;Refractory Disease;Relapse;Resistance;Reticular Cell;Role;secondary lymphoid organ;Signal Transduction;single cell analysis;Site;Sorting;Source;Specific qualifier value;Specimen;Stromal Cells;Stromal Neoplasm;T-Cell Lymphoma;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic target;Therapeutically Targetable;Transcriptional Activation;transcriptional reprogramming;tumor;tumor microenvironment

PROJECT_TITLE: Notch ligands as oncogenic drivers and therapeutic targets in T-cell lymphomas

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetics;Hematology;Orphan Drug;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Project Narrative Chronic myelomonocytic leukemia (CMML) is an aggressive blood cancer for which we unfortunately have no curative therapies. Our group has now identified that 20% of CMML patients harbor a second subclonal disease that confers unique clinical characteristics. This R37 extension will build on the CMML PDX models generated during the parent grant to model this new discovery, confirm biologic clone-to-clone interactions, and begin to determine how these two distinct clones collaborate to result in fully manifested CMML.

PI_NAMEs: PADRON, ERIC  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Acute leukemia;Acute Myelocytic Leukemia;Affect;Architecture;Binding;Biological;Biological Assay;Biology;Cells;Characteristics;Chromatin;Chronic;Chronic Myelomonocytic Leukemia;Clinical;Clinical Data;Clinical Trials;Clone Cells;Collaborations;Communication;Credentialing;curative treatments;cytokine;Cytokine Signaling;cytopenia;Data;Dependence;Disease;disease model;Dysplasia;efficacy evaluation;Engraftment;experience;Gene Mutation;Genes;Genetic;Genetically Engineered Mouse;Genotype;Goals;hematopoietic differentiation;Hematopoietic Neoplasms;Histologic;Human;Human Characteristics;human disease;Hybrids;Immunocompromised Host;improved;in vivo;Knockout Mice;leukemia;Leukemic Cell;Marrow;mast cell;Mast Cell Neoplasm;Messenger RNA;Modeling;Monocytosis;mouse model;Mouse Strains;Mus;mutant;Mutate;Mutation;mutational status;Myeloproliferative disease;nano-string;Natural History;new therapeutic target;non-genetic;novel;novel therapeutic intervention;parent grant;patient derived xenograft model;Patients;Phase;phase 2 study;Phenotype;pre-clinical;predicting response;prospective;Proteome;Recurrence;Resolution;response;RNA;RNA Splicing;Sampling;screening;Signal Pathway;Signaling Protein;Spliceosomes;stem cells;success;System;Testing;Therapeutic;therapeutic target;Tissue Banks;transcriptome;Translating;Xenograft procedure

PROJECT_TITLE: Developing and credentialing patient-derived xenograft models to advance therapeutic approaches for chronic myelomonocytic leukemia


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

PHR: From mouse to man, traumatic injuries to the joint cause inflammation and, when the instigating injury remains uncorrected, persistent inflammation culminates in irreversible degradation of all joint structures. This project develops and validates a novel joint injectable anti-inflammatory sustained drug delivery system in client owned canines presenting with knee injury (cruciate ligament disease). Successful completion of this study will advance this new technology towards human clinical implementation and validate, for the first time, the safety and therapeutic efficacy of IL-1Ra delivered from mechanically activated microcapsules (MAMCs) compared to systemic and soluble IL-1Ra joint injections in a pilot clinical trial (executed through the PennVet Veterinary Clinical Investigation Center).

PI_NAMEs: MAUCK, ROBERT L (contact)

PROJECT_TERMS: Acute;Affect;Aftercare;anakinra;antagonist;anterior cruciate ligament injury;Anti-Inflammatory Agents;Arthralgia;Atomic Force Microscopy;Attenuated;Biological Response Modifier Therapy;Biopsy;Canis familiaris;capsule;Cephalic;Client;Clinical;clinical implementation;clinical investigation;Clinical Trials;clinically relevant;companion animal;cytokine;Data;design;Diagnosis;disability;Disease;Dose;Drug Delivery Systems;Encapsulated;Enrollment;Enzyme-Linked Immunosorbent Assay;Enzymes;Evaluation;Exposure to;Formulation;Glucocorticoids;Health;Histologic;Hour;Human;improved;Inflammation;Inflammatory;inflammatory marker;Injectable;Injections;Injury;Interleukin-1 beta;Intra-Articular Injections;joint inflammation;joint loading;Joints;Knee Injuries;Knee Osteoarthritis;ligament injury;Ligaments;Limb structure;Link;man;Measures;mechanical load;Mechanics;Microcapsules drug delivery system;Microspheres;Miniature Swine;Modeling;Mus;new technology;novel;novel therapeutics;Operative Surgical Procedures;Organ Culture Techniques;Osteotomy;Outcome;Pain;Pain Measurement;particle;Patients;postoperative recovery;receptor;repaired;Reporting;residence;Rupture;Safety;Severities;Signal Transduction;Stifle joint;Stimulus;Structure;Synovial Fluid;Synovial joint;Synovial Membrane;Synovitis;System;Technology;Technology Assessment;Testing;Therapeutic;Time;Tissues;Traumatic injury;Treatment Efficacy;Weight-Bearing state

PROJECT_TITLE: Evaluation of Anti-Inflammatory Delivery from Mechanically-Activated Microspheres in the Context of Cruciate Ligament Injury

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]