ORG_DEPT: BIOLOGY

PHR: PROJECT NARRATIVE In animals with internal fertilization, secreted proteins transferred in seminal fluid are required for fertility, and have been canonically thought of as male-specific products. We discovered that many of the seminal fluid genes are also expressed by specialized cell types in the female reproductive tract. This project interrogates the functions and behavior of the male- vs female-contributed protein fractions and the extent to which their actions are cooperative or sexually antagonistic, toward a deeper understanding of the molecular mechanisms supporting fertility.

PI_NAMEs: THAYER, RACHEL C (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Address;Amino Acid Sequence;Animals;antagonist;Behavior;Biochemical;Biology;Candidate Disease Gene;career;Case Study;Categories;Cell Nucleus;cell type;Cervical;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;comparative genomics;Conflict (Psychology);Drosophila melanogaster;Ejaculation;Epitopes;Evaluation;Evolution;Exhibits;experimental study;Female;female reproductive tract;Fertility;Fertilization;fitness;fly;Future;Gene Deletion;Gene Duplication;Gene Family;Gene Proteins;Genes;genetic approach;Genetic Models;Genetic Variation;Genome engineering;Genomics;Genotype;Germ Cells;Gland;Human;Human Genetics;Incidence;interest;Investigation;Investments;Knock-out;knockout gene;Knowledge;Libraries;male;Mammalian Oviducts;Mammals;Mediating;Messenger RNA;Methodology;Methods;Modality;model organism;Modeling;Molecular;nanobodies;novel;Organ;Outcome;Oviposition;Partner in relationship;Pattern;Peptides;Phylogenetic Analysis;Physiological;Physiology;Population Genetics;Process;Production;Proliferating;protein expression;Protein Secretion;Proteins;Recording of previous events;reproductive;Reproductive Physiology;Role;Seminal;Seminal fluid;Series;Serine Protease;sex;Sleep;sperm cell;Testing;Time;training opportunity;transcriptome sequencing;transcriptomics;Transgenic Organisms;Uterus;vaginal fluid;Visualization;women versus men;Work

PROJECT_TITLE: The function and evolution of female-expressed seminal fluid proteins

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Mental Health;Mental Illness;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE 10.6 million people fell ill with tuberculosis (TB) in 2021 and as many as half will be burdened by common mental disorders (CMDs). If successful, the proposed research will help establish an intervention that can mitigate the negative impacts of CMDs on TB outcomes.

PI_NAMEs: WEST, NORA SOLON (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Address;Africa;antenatal care;Anxiety;Area;Behavior;Behavioral;career;career development;Caring;Cause of Death;Cessation of life;Clinic;Clinical Trials;common symptom;comorbidity;Consolidated Framework for Implementation Research;Consultations;Data;Dedications;Diagnosis;disability;effectiveness evaluation;Effectiveness of Interventions;Enrollment;Environment;evidence base;Evidence based intervention;experience;Feedback;Focus Groups;follow-up;Future;global health;Goals;Health;Health Personnel;Health system;HIV;implementation evaluation;implementation facilitators;implementation outcomes;implementation science;improved;Individual;International;Intervention;Intervention Studies;Interview;Longitudinal Studies;Mental association;Mental Depression;Mental disorders;Mental Health;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Modeling;Modification;Motivation;multidisciplinary;Outcome;Outpatients;Participant;Personal Satisfaction;Persons;Phase;pilot test;post-traumatic stress;Process;psychologic;psychosocial;Pulmonary Tuberculosis;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;research and development;Research Design;Research Infrastructure;Research Personnel;Resource-limited setting;Resources;Risk;Surveys;Symptoms;Testing;Training;treatment adherence;treatment duration;Treatment Failure;Treatment outcome;treatment services;Tuberculosis;tuberculosis treatment;Uganda;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Addressing unmet needs: intervention approaches for mental health among people with tuberculosiss in Uganda

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PITTSBURGH

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Subtle alternations of physical activity patterns at an early stage may act as preclinical indicators of Alzheimer’s disease and related dementias (ADRD). This project is designed to explore whether altered accelerometer-derived physical activity rhythms predict brain and cognitive aging and increase risk of ADRD. Identifying such changes before clinical manifestations of dementia may facilitate understanding of common pathophysiological mechanisms connecting motor function and brain aging and may suggest novel directions for tailored interventions to prevent or delay the onset of ADRD.

PI_NAMEs: CAI, YURUN  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Accelerometer;Activities of Daily Living;Adult;Affect;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Area;Attention;Baltimore;Biological Markers;Brain;brain magnetic resonance imaging;brain volume;Cerebellum;cerebral atrophy;Classification;Clinical;clinically significant;Cognition;Cognitive;cognitive ability;Cognitive aging;cognitive function;cohort;connectome;Data;Data Set;Dementia;Deposition;design;Diagnosis;Disease;Disease Progression;disorder risk;diverse data;Early identification;Entropy;executive function;falls;frontal lobe;Funding;gray matter;Health;Hippocampus;Human;Impaired cognition;Impairment;Individual;insight;Intervention;Language;Lesion;Link;Longitudinal Studies;Measurement;Measures;Memory;Methods;mild cognitive impairment;moderate-to-vigorous physical activity;Monitor;Motor;motor disorder;neocortical;Nerve Degeneration;neurophysiology;next generation;novel;Occipital lobe;older adult;Older Population;Outcome;Parietal Lobe;Participant;Pathologic;Pathologic Processes;Pathway interactions;Patient Self-Report;Pattern;Persons;Phase;Physical activity;Physiological;Pilot Projects;Plasma;Positron-Emission Tomography;Posture;pre-clinical;prevent;Probability;programs;Research;Research Personnel;Research Project Grants;response;Rest;Risk;Science;Secondary to;Signal Transduction;System;tau aggregation;tau Proteins;Temporal Lobe;Testing;Time;time use;Visuospatial;white matter;White Matter Hyperintensity

PROJECT_TITLE: A novel physical activity metric predicts cognitive and brain aging and ADRD risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-W (02)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative:  No vaccines are currently licensed to prevent human brucellosis and existing vaccines for livestock are not entirely efficacious. However, mechanisms underlying the ability of Brucella to subvert vaccine-mediated immunity remain unclear. In this proposal, we will investigate both how vaccines alter metabolism to protect the host, and how Brucella is able to evade adaptive immunity, which therefore could improve the future rational design of highly effective vaccines against Brucella.

PI_NAMEs: ATEYA, MOSTAFA F (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: adaptive immunity;Affect;Animals;Antibodies;Antibody Formation;Antibody-mediated protection;Attenuated Vaccines;B-Lymphocytes;Brucella;Brucella melitensis;Brucella Vaccine;Brucellosis;Cells;chronic infection;Complement;Complement Receptor;Data;Dendritic Cells;Disease;Exposure to;extracellular;Fc Receptor;Future;Genes;Genome;Glucose;Glucose Transporter;Goals;Human;Humoral Immunities;Immunity;Immunoglobulin Class Switching;Immunoglobulin M;improved;in vivo;Infection;Infection Control;Knowledge;Licensing;Livestock;Macrophage;Mass Fragmentography;Mediating;metabolic profile;Metabolism;Mus;mutant;Mutation;neglect;Output;pathogen;Patients;Predisposition;prevent;Primary Infection;Proteins;rational design;Role;Site;Surface;Testing;Tissues;Vaccinated;Vaccination;Vaccines;Virulence;Virulence Factors;Wild Type Mouse;Zoonoses

PROJECT_TITLE: Antibody Mediated Immunity Against Brucella

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Data Science;Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pain Research;Patient Safety

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Timely and accurate clinical decision-making is critical for public health, by aiding in the early detection of outbreaks, improving patient outcomes, and achieving higher-quality health care. Clinicians, especially in time- sensitive settings like emergency departments (EDs), often lack just-in-time access to reliable evidence-based information, leading to suboptimal patient care decisions. This research aims to a develop clinically reliable and transparent large language model (LLM)-based question answering (QA) system, and translate it into a clinical chatbot for timely, precise, evidence-based decision-making, ultimately improving patient outcomes and contributing to public health.

PI_NAMEs: XIE, QIANQIAN  (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Abdominal Pain;Accident and Emergency department;Address;Adoption;Artificial Intelligence;Automated Abstracting;biomedical data science;career;chatbot;Chest Pain;Clinical;clinical center;Clinical Data;clinical decision support;clinical decision-making;Clinical Informatics;Clinical Medicine;clinical practice;Code;Complex;Data;Data Set;Decision Making;Diagnostic;Diagnostic Errors;Disease;Disease Outbreaks;distraction;Early Diagnosis;Effectiveness;Electronic Health Record;Emergency Care;Emergency Department Physician;Emergency Medicine;Environment;evidence base;Evidence Based Medicine;Fever;Florida;Goals;Guidelines;Hallucinations;Headache;health care delivery;health care quality;Health system;Healthcare;Human;improved;individual patient;innovation;Knowledge;large datasets;large language model;Lead;Literature;Medical;Medical Students;Medicine;Mental Health;Mentors;Mentorship;method development;Methods;Modeling;multimodal data;multimodality;multitask;next generation;novel;open source;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phase;Physicians;Play;Positioning Attribute;pre-trained model;Predictive Analytics;pressure;Process;Public Health;Recommendation;Records;recruit;Research;Research Proposals;Resources;response;Retrieval;Software Validation;Solid;Source;structured data;supercomputer;System;Therapeutic;Time;tool;Training;Translating;Trust;trustworthiness;Universities;unstructured data;usability

PROJECT_TITLE: Reliable Question-Answering Frameworks for Clinical Decision Support using Domain-specific Large Language Models

STUDY_SECTION_NAME: Special Emphasis Panel[ZLM1 AS-C (01)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Narrative  Epigenetic age estimators provide a powerful tool in determining epigenetic age, alleviating the necessity of monitoring cohorts of animals throughout their lives in captivity or in the wild. Sex and gender differences in aging and other health outcomes are frequently severely confounded by behavioral and environmental factors, mandating the use of animal models. The present study, by using outbred deer mice (Peromyscus) will explore how genetic relatedness of parents, history of social interactions, and CDK8/19 inhibition impact epigenetic age.

PI_NAMEs: KIARIS, HIPPOKRATIS  (contact);RONINSON, IGOR B

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Address;Age;age acceleration;Aging;Animal Model;Animals;anti aging;Behavioral;biobehavior;Breeding;Caring;Cell Aging;Chronic;cohort;comparative;Cyclin-Dependent Kinases;Data;Daughter;Deer Mouse;Development;Disparity;DNA Methylation;Electronics;endoplasmic reticulum stress;Environment;Environmental Risk Factor;Epigenetic age;epigenetic aging;epigenome;Evaluation;exhaust;Exhibits;experimental study;Female;Fibroblasts;gender difference;Genetic;Genetic Transcription;Health;Health Status;Heterozygote;Human;Hybrids;In Vitro;Intervention;Laboratory mice;life span;Link;male;Mammals;men;Mitochondria;Molecular Chaperones;Monitor;motherhood;Mothers;Mus;offspring;Outcome;outcome disparities;Pair Bond;Parents;Peromyscus;pharmacologic;Population;prevent;Proteins;Recording of previous events;Records;Reporting;Resolution;response;sex;Sex Differences;Signal Induction;Social Environment;Social Interaction;socioenvironmental factor;Son;South Carolina;Telomere Shortening;Testing;Time;tool;transcriptome sequencing;trend;Universities;Weaning;Woman

PROJECT_TITLE: Motherhood, pair bonding and parental relatedness as modulators of epigenetic aging


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pediatric;Pneumonia;Pneumonia and Influenza

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Children are disproportionately affected by respiratory viruses and at risk of developing severe viral infections requiring admission to the pediatric intensive care unit. Once a child develops a severe disease, treatment options are currently limited to supportive measures that do not treat the underlying pathology. This proposal will provide insight into how the pediatric immune system promotes recovery from severe viral respiratory infections to inform the design of new treatments aimed at accelerating recovery and reducing the risk of complications from severe viral respiratory infections.

PI_NAMEs: PRIGGE, ANDREW  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: 5 year old;Acceleration;Active Learning;Acute;Address;Adenosine;Admission activity;Adolescent;Adoptive Transfer;Adult;Affect;Age;age difference;age related;Alveolar;alveolar epithelium;Amphiregulin;Biological Assay;Bronchoalveolar Lavage Fluid;cardiovascular health;career;career development;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Cellular biology;Child;Child Health;Childhood;Clinical;Data;design;dimensional analysis;Disease;Dose;epithelial repair;Exhibits;extracellular;Foundations;FOXP3 gene;Functional disorder;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Genomics;Goals;Hospitalization;Human;Hypoxemic Respiratory Failure;Immune;Immune system;Impairment;improved;Infection;Inflammation;Inflammatory Response;Influenza;Influenza A virus;influenza infection;influenza pneumonia;influenza virus strain;injury and repair;insight;keratin 5;Knowledge;Laboratories;Life;Lung;lung failure;lung injury;lung repair;Measures;Mechanical ventilation;Mediating;Mediator;Methods;Molecular;mouse model;Mus;novel;novel therapeutic intervention;Outcome;pathogen;Pathology;Pathway interactions;Patients;Pediatric Intensive Care Units;pediatric patients;Phenotype;Play;Pneumonia;pneumonia model;Predisposition;Process;programs;progression risk;Publishing;pulmonary function;Recovery;Recovery of Function;recruit;Regulatory T-Lymphocyte;repair function;repaired;Reporting;Research;Research Personnel;Resolution;respiratory health;respiratory virus;response;Risk;Risk Reduction;Role;Severities;single-cell RNA sequencing;Structure;Structure of mucous membrane of nose;Supportive care;Suspensions;Systems Biology;T cell response;T-Lymphocyte;Testing;therapeutic target;Time;tissue repair;Training;training opportunity;transcription factor;translational approach;translational study;Viral;Viral Pneumonia;Viral Respiratory Tract Infection;Virus Diseases;Work

PROJECT_TITLE: Multidimensional analysis of the regulatory T cell response in children with severe viral pneumonia

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (M3)]


ADMINISTERING_IC: HD

ED_INST_TYPE: PRIMATE CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cerebral Palsy;Childhood Injury;Infectious Diseases;Maternal Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Unintentional Childhood Injury;Women's Health Research

ORG_CITY: PORTLAND

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Premature birth is a significant obstetrical problem that is associated with fetal brain injury and a high risk of later-life neurological and behavioral deficits. This proposal will expand our understanding of mechanisms of fetal neuroinflammation and white matter injury in response to intrauterine Ureaplasma infection that causes premature birth.

PI_NAMEs: KELLEHER, MEREDITH ANNE (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: Amniotic Fluid;Animal Model;Animals;antenatal;Anti-Inflammatory Agents;Antibiotic Therapy;Antibiotics;Archives;Astrocytes;Azithromycin;Bacteria;Behavioral;Biological Models;Birth;Brain;Brain Injuries;brain tissue;Cell Culture Techniques;Cell Death;Cell Maturation;Cells;Cerebral Palsy;Clinical;Clinical Management;clinically relevant;Cognitive;Cognitive deficits;cohort;cytokine;Data;Demyelinating Diseases;Demyelinations;Development;Digestion;Discipline of obstetrics;experience;Extracellular Matrix;fetal;fetal brain injury;Fetal Lung;Fetal Membranes;Future;Gene Expression;Gene Expression Profiling;glial activation;Health;hemodynamics;high risk;Hippocampus;Histologic;Human;Hyaluronic Acid;Hyaluronidase;Immune;immune cell infiltrate;Immunohistochemistry;improved;Induced Labor;Infant;Infection;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;innovation;intraamniotic infection;intrauterine infection;intrauterine inflammation;intraventricular hemorrhage;Laboratories;late life;Lesion;Longitudinal Studies;lung injury;Macaca mulatta;Macrolides;Mediating;Microglia;Modeling;Molecular;Mothers;Motor;Multiple Sclerosis;Myelin;myelination;Neonatal;neonate;neurodevelopment;Neurodevelopmental Impairment;neuroinflammation;Neurologic;Neurological outcome;neuroprotection;nonhuman primate;novel;oligodendrocyte progenitor;Oligodendroglia;Outcome;Paraffin Embedding;Patients;Perinatal;perinatal brain;Perinatal Brain Injury;Pharmaceutical Preparations;Phenotype;Physiology;Placenta;postnatal;postnatal development;preclinical study;Pregnancy;pregnant;premature;Premature Birth;Premature Infant;Premature Labor;Preterm brain injury;prevent;Process;Production;protein expression;Proteins;receptor;Research Personnel;response;Risk;RNA;Role;Sampling;Sensory;stem cells;systemic inflammatory response;Techniques;Testing;therapy development;Tissue Banks;Tissue Extracts;tissue resource;Tissues;transcriptomics;treatment group;ultrasound;Ureaplasma Infections;Ureaplasma parvum;vascular inflammation;Ventricular;white matter;white matter injury

PROJECT_TITLE: Microglial Polarization: Brain Injury or Protection in Response to Intrauterine Infection

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Networking and Information Technology R&D (NITRD);Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PI_NAMEs: TOPF, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: 3-Dimensional;Address;Adjuvant Radiotherapy;Anatomy;Area;Augmented Reality;augmented reality headset;Beds;Cadaver;Cancer Model;cancer surgery;cancer therapy;career;Cessation of life;chemotherapy;Clinical;Clinical Trials;Clinical Trials Design;Collaborations;Communication;Complex;computer generated;Computer software;cost;Custom;Data;Defect;Effectiveness;Engineering;Environment;Excision;experience;Feasibility Studies;Foundations;Future;Goals;Hand;Head and Neck Cancer;head and neck cancer patient;Head and neck structure;Head and Neck Surgery;hologram;Image;improved;Locally Advanced Malignant Neoplasm;malignant mouth neoplasm;Malignant Neoplasms;Measures;Mentors;Modeling;mortality;new technology;Operating Rooms;Operative Surgical Procedures;Outcome;Pathologist;Patient-Focused Outcomes;Patients;portability;Prognostic Factor;prospective;Protocols documentation;Quality of life;Recurrence;Resected;Risk;Sampling;Scanning;Scientist;Site;soft tissue;Solid;Specimen;standard of care;Surgeon;Surgical margins;Surgical Oncology;Surgical Pathology;survival outcome;System;Technology;Telephone;three-dimensional modeling;Time;Tissues;Training;tumor;verbal;virtual;Visual Aid;Voice

PROJECT_TITLE: Augmented Reality to Guide Head and Neck Cancer Surgery

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Injury;Dental, Oral, and Craniofacial Disease;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: SAN ANTONIO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Public Health Relevance Statement. Violence is a serious public health problem in the United States that directly or vicariously impacts the lives of millions of Americans. Violence exposure has significant consequences for health and healthcare utilization, yet research overlooks the effects of exposure to community-based violence on dental care utilization. We use data from three national longitudinal datasets to pioneer research on exposure to community violence and dental care utilization over the lifespan: (1) the National Longitudinal Study of Adolescent to Adult Health, (2) the Future of Families and Child Wellbeing Study, and (3) Neighborhood Gun Violence and Health in 100 Cities Study.

PI_NAMEs: MUNGIA, RAHMA  (contact);TESTA, ALEXANDER MICHAEL

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Adolescence;Adolescent;Adult;adverse childhood events;Age;American;Applications Grants;Behavior;behavioral and social science;Birth;care systems;Cause of Death;Censuses;Child;Child Welfare;Childhood;Cities;Communities;Community Healthcare;community violence;cost;Data;Data Set;Data Sources;Dental;Dental Care;Dentistry;Development;emerging adulthood;Environment;ethnic minority;Ethnic Origin;experience;Exposure to;Facilities and Administrative Costs;Family;Financial cost;Firearms;Foundations;Funding;Future;Gun injury;gun violence;Health;health care service;health care service utilization;health data;health disparity;Hearing;Human;improved;Individual;Interpersonal Violence;Intervention;intimate partner violence;Investigation;Knowledge;Life Cycle Stages;life span;Literature;longitudinal dataset;Longitudinal Studies;low socioeconomic status;Maintenance;Measures;Minority Groups;National Institute of Dental and Craniofacial Research;National Longitudinal Survey of Adolescent to Adult Health;Neighborhoods;novel;Oral health;Pain;Pattern;Personal Satisfaction;Persons;Population;Prevention;Public Health;public health relevance;Qualifying;Quality of life;R24;Race;racial minority;Racial Segregation;Reduce health disparities;Research;Risk;Role;Science;Shapes;social;social health determinants;social science research;Socioeconomic Status;Source;Time;Translational Research;Trauma;treatment services;United States;uptake;Variant;Victimization;Violence;violence exposure;violent crime;Visit

PROJECT_TITLE: Violence Exposure and Dental Care Utilization Over the Lifespan

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 CC (13)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Pediatric;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Social Determinants of Health;Unintentional Childhood Injury

PHR: PROJECT NARRATIVE Although the frequency of athletic knee injuries in children has skyrocketed, delayed surgery due to multilevel barriers can have lifelong consequences. This project will identify barriers to timely surgery in Hispanic high school athletes and design and test an intervention to reduce delayed treatment. In the future, the knowledge and intervention developed in this study will be adapted to address similar disparities in other communities, resulting in more equitable care for all youth athletes.

PI_NAMEs: PATEL, NEERAJ M. (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acute;Address;Adolescent;anterior cruciate ligament injury;Appointment;Arthritis;Arthroscopy;Athletic;Attitude;bilingualism;care seeking;career;career development;Caring;Chicago;Child;Childhood;Childhood Injury;Clinic;Clinical Trials;Collaborations;Communities;community advisory board;community center;community engaged research;community research;Community Trial;community-centered;culturally appropriate intervention;Data;Day Surgery;design;Development;Development Plans;Discipline;Disparity;disparity reduction;Education;Equity;Evaluation;evidence base;expectation;Familiarity;Family;Feasibility Studies;Feedback;Female;Focus Groups;Foundations;Frequencies;Funding;Future;Goals;health equity;Healthcare Systems;high school;Hispanic;hispanic community;Hispanic Women;implementation facilitators;implementation framework;implementation science;Incidence;Inequity;Injury;Institution;Insurance;International;Intervention;Interview;Knee;Knee Injuries;Knowledge;Language;male;member;Mentors;Mentorship;Methods;Modeling;multidisciplinary;Not Hispanic or Latino;Operative Surgical Procedures;Orthopedics;Parents;patient navigator;patient oriented;Patient Outcomes Assessments;Patients;Pediatric Hospitals;pediatrician;Pilot Projects;Population;population health;Process;programs;Publishing;Qualitative Methods;Randomized;Repeat Surgery;Research;Research Design;Research Personnel;Resources;Risk;Scientist;Seasons;Soccer;Spanish;Specialist;Sports;Sports Medicine;Surgeon;Surveys;Testing;therapy design;Training;Universities;user centered design;Voice;Work;Youth

PROJECT_TITLE: RED KARD: Reducing Disparities in Knee Arthroscopy for Adolescents

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Burden of Illness;Clinical Research;Dementia;Neurodegenerative

ORG_CITY: Los Angeles

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project narrative: This funding application seeks support for the implementation of Wave 2 of the Longitudinal Aging Study in India (LASI). Wave 2 of LASI plays a pivotal role in advancing our understanding of the aging process in India, addressing the unique challenges faced by older adults, and facilitating the formulation of policies and programs to enhance their well-being and quality of life. Furthermore, the data collected during LASI Wave 2 will provide crucial backing for the Longitudinal Aging Study in India- Diagnostic Assessment of Dementia (LASI-DAD). LASI-DAD's data will significantly contribute to our understanding of dementia prevalence, incidence, cognitive changes over time, and the comprehensive evaluation of the economic and caregiving burdens associated with dementia, both at the population level and among diverse demographic groups.

PI_NAMEs: LEE, JINKOOK  (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Address;Age;Aging;aging process;Ally;Behavioral;care giving burden;Cognition;cognitive change;COVID-19;Data;Dementia;dementia burden;Diagnostic;Economic Burden;economic evaluation;Eligibility Determination;Ensure;Ethics;follow-up;Formulation;Funding;Future;Genomics;Grant;Health and Retirement Study;Household;Incidence;India;instrument;International;Interview;late life;Measures;Monitor;older adult;Parents;Personal Satisfaction;Play;Policies;Population;Population Sciences;Prevalence;programs;quality assurance;Quality Control;Quality of life;Research;Research Personnel;Respondent;Role;Sampling;socioeconomics;Surveys;Testing;Time;Trainers Training;Update

PROJECT_TITLE: Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Surveys in India (LASI)


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE New research methods have made it possible to create and characterize dozens of animal models of human cognitive disorders in parallel. By combining high throughput CRISPR technology with state-of-the-art sequencing, imaging, and behavioral assays, this project will generate highly detailed quantitative descriptions of dozens of distinct models of human neurodevelopmental disorders in zebrafish. Computational tools will then be used to interpret, relate, and predict phenotypes, providing insights about the cellular and molecular pathways involved in brain development and cognitive dysfunction.

PI_NAMEs: CAREY, CLAYTON  (contact)

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Acoustics;Address;Animal Model;Animals;Bar Codes;Behavior;Behavioral;Behavioral Assay;behavioral outcome;behavioral phenotyping;Biological;Biological Assay;Biology;Brain;brain morphology;Brain region;career development;Cell Physiology;cell type;Cellular biology;Cellular Morphology;Characteristics;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition Disorders;Cognitive;cohort;computerized tools;CRISPR/Cas technology;Data;Data Analyses;Data Science;Data Set;Dedications;Descriptor;Development;Developmental Biology;Dimensions;Disease;disease model;DNA;droplet sequencing;Embryo;experimental study;Fostering;functional genomics;Gene Expression Profile;gene function;Generations;Genes;Genetic;Genetic Diseases;Genetic Transcription;genome editing;Genotype;Goals;high dimensionality;Human;human model;Image;Impaired cognition;improved;Individual;Informatics;insight;Joints;Knock-out;knowledge integration;Laboratories;large scale production;Larva;Lead;Link;Machine Learning;machine learning prediction;machine vision;Manuals;Measurement;Measures;member;Mentors;Mentorship;Methodology;Microfluidics;Modeling;Molecular;molecular modeling;molecular phenotype;Morphology;multimodality;mutant;Mutate;Neurodevelopmental Disorder;Neurons;new technology;novel strategies;novel therapeutic intervention;Pathway interactions;Phenotype;phenotypic data;Physiological;Postdoctoral Fellow;predictive modeling;Protocols documentation;Quantitative Microscopy;Research;Research Methodology;Resolution;response;Sampling;single-cell RNA sequencing;Stimulus;Structure;Syndrome;System;Techniques;Technology;therapeutic development;Therapeutic Intervention;Time;tool;Training;transcription factor;transcriptome;Universities;Utah;Visual;Work;Zebrafish

PROJECT_TITLE: Integrated multimodal phenotyping of zebrafish models of human cognitive disorders

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: WASHINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative  We aim to create an affordable device for imaging calcium transients, using pinhole illumination to create optical sectioning, which will reduce background light (F0) and consequently increasing the optical signal (dF/F0). The device will be simple enough to share as an open-source tool or as a modification of existing brightfield fluorescent microscopes.

PI_NAMEs: WU, JIAN-YOUNG  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TITLE: A low cost approach for imaging calcium signals from a large population of neurons

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Patient Safety;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project narrative Aging involves a gradual clinical decline in cognitive and physical function and often the development of various comorbidities. However, significant life events, such as a cancer diagnosis, cancer treatment, or other individual-level and societal-level factors can accelerate clinical decline and aging in cancer survivors compared to other older people without a cancer diagnosis. The completion of this study will identify targetable multilevel aging risk factors in the older population with lung cancer, as well as provide a valuable monitoring tool to predict dynamic risk of aging-related clinical decline, allowing for a deeper understanding of drivers of aging acceleration and timely intervention before clinical decline occurs.

PI_NAMEs: CHOI, EUNJI  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acceleration;active method;advanced analytics;Affect;Aftercare;Age;age acceleration;Aging;aging process;aging related;anti-cancer research;Big Data;bridge program;California;cancer diagnosis;Cancer Etiology;Cancer Patient;Cancer Survivor;Cancer Survivorship;cancer therapy;career;Cessation of life;Characteristics;Chronic Disease;Clinical;clinical predictive model;clinical risk;Code;cognitive function;Cohort Studies;Community Health;Community Healthcare;Community Practice;comorbidity;Data;Data Analytics;Data Science;Databases;Development;Diagnosis;Disease;Disparity;drivers of aging;Electronic Health Record;electronic health record system;Electronics;Environment;epidemiologic data;Epidemiology;epidemiology study;Equipment;Event;Exposure to;Financial Hardship;Gender;Goals;Grant;Health;health data;health goals;Health Status;Healthcare Systems;healthy aging;human old age (65+);Immunotherapy;indexing;Individual;insight;Intervention;Knowledge;Life;Link;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Medical;Medical Care Costs;Medicare;Medicare claim;Mentorship;Methodology;Methods;Modeling;Monitor;mortality disparity;Neighborhoods;neoplasm registry;Non-Small-Cell Lung Carcinoma;Older Population;Outcome;Patients;Persons;Physical Function;pre-clinical;primary outcome;Procedures;Process;Public Health;quantification of aging;Race;racial disparity;Racial Segregation;Research;research clinical testing;Research Personnel;Research Project Grants;Risk;Risk Factors;risk prediction;risk prediction model;screening;skills;social factors;social health determinants;Socioeconomic Status;Standardization;Survivors;Time;tool;Training;Treatment-related toxicity;tumor;Update;Urbanization;user-friendly;Validation

PROJECT_TITLE: Evaluation of clinical and social factors associated with deficit accumulation trajectories in older survivors with early-stage non-small cell lung cancer

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Aging;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Contraception/Reproduction;Estrogen;Heart Disease;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Prevention;Sleep Research;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Women are twice as likely as men to develop post-traumatic stress disorder (PTSD), a chronic stress disorder that may negate the cardiovascular (CV) protection conferred by female hormones before menopause. The proposed longitudinal study builds on cross-sectional findings from my current K01 to identify low estradiol levels and sleep disturbances as potential mechanisms in the development of CV disease in young women. This follow-up study (two years later) of the vascular and neural alterations in young women with PTSD will help inform the development of strategies to improve CV health in this growing and high-risk population of women.

PI_NAMEs: FONKOUE, IDA TCHUISSEU (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Acceleration;actigraphy;Adult;Age;arterial stiffness;arterial tonometry;Autonomic Dysfunction;Award;Biological;Biological Availability;Blood Vessels;Body mass index;brachial artery;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular Physiology;Cardiovascular system;career;career development;Cause of Death;Centers for Disease Control and Prevention (U.S.);Characteristics;Chronic stress;Clinical;Clinical Research;Clinical Sciences;Data;Development;Diagnosis;Disease;early onset;Endothelium;Environment;Estradiol;estrogenic;Female;Female of child bearing age;follow-up;Follow-Up Studies;Foundations;Funding;Future;Generalized Anxiety Disorder;Goals;Grant;Health;Heart Diseases;high risk population;Hormonal;Hormones;Hour;Hypertension;Impairment;improved;improvement on sleep;in vivo;Inosine Dialdehyde;Intervention;K-Series Research Career Programs;Lead;Long-Term Effects;Longitudinal Studies;Master of Science;Measures;Mediating;men;Menopause;Mentorship;Minnesota;multidisciplinary;Nerve;neural;neurobiological mechanism;Neurosecretory Systems;Nitric Oxide;Outcome;Panic Disorder;Pathology;Pathway interactions;Peripheral;Plasma;Play;Population;Post-Traumatic Stress Disorders;Postmenopause;Premenopause;Prevalence;prevent;Prevention strategy;Production;programs;protective effect;Psyche structure;Research;Research Project Grants;Resources;Rest;Risk;Risk Factors;Role;Severities;Sleep;Sleep disturbances;Stress;stress disorder;Surveys;Sympathetic Nervous System;Testing;Time;tonometry;Translational Research;Trauma;trauma exposure;United States;United States National Institutes of Health;Universities;Vascular Diseases;Vascular Endothelium;Vulnerable Populations;Woman;Women's Health;Women's mortality;Work;young woman

PROJECT_TITLE: Longitudinal changes in vascular and autonomic function in premenopausal women with PTSD

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-N (M1)]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Primary Health Care

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Infants born prematurely represent a vulnerable population that has an elevated likelihood of developing social and cognitive impairments. The present study aims to use non-invasive infant neuroimaging methods to identify the neural mechanisms underlying social and cognitive difficulties in both preterm and full term infants. Through charting brain and behavioral development longitudinally we hope to inform early identification and intervention strategies.

PI_NAMEs: KELSEY, CAROLINE M. (contact)

PROGRAM_OFFICER_NAME: KING, TRACY

PROJECT_TERMS: Age;Autism Diagnosis;autism spectrum disorder;Award;Behavioral;behavioral impairment;Biological Markers;Blood flow;Brain;candidate marker;Cerebrovascular Circulation;Child;Chronology;Clinic;Clinical;Cognitive;cognitive development;Collection;cost;Data;Development;Developmental Delay Disorders;developmental disease;Diagnosis;early childhood;Early identification;Early Intervention;Electroencephalography;Enrollment;Equilibrium;experience;Faculty;Fibrinogen;follow-up;frontal lobe;functional near infrared spectroscopy;Funding;Future;Goals;Grant;Health;Health care facility;Hemoglobin;Heterogeneity;high risk;high risk infant;Impaired cognition;Impairment;improved;indexing;Infant;Interruption;Intervention;intervention program;Investigation;Language;Learning;Life;life span;Link;Measures;Mediating;Medical;Metabolic;Methods;Mission;Motor;multimodality;National Institute of Child Health and Human Development;neural;neurodevelopment;neuroimaging;neuromechanism;Neurons;neurovascular;neurovascular coupling;novel;Nutrient;Oxygen;Participant;Pattern;Personal Satisfaction;Phase;Population;Positioning Attribute;postsynaptic;Pregnancy;premature;Premature Birth;Premature Infant;Primary Care;primary care clinic;primary care visit;Process;programs;Property;psychological outcomes;Public Health;Qualifying;Questionnaires;recruit;Research;Research Personnel;Resolution;response;Rest;Sampling;screening program;Services;social;Social Development;Synaptic Potentials;synaptogenesis;Techniques;temporal measurement;Testing;Theoretical model;Time;Training;treatment response;United States;Visit;Vulnerable Populations;Well baby checks

PROJECT_TITLE: Neural Markers of Developmental Delays in Premature and Full Term Infants

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE In the recovery from work literature, strain refers to effects (e.g., on affect, physiology, fatigue levels, etc.) of exposure to stressors or any other demands which, if allowed to accumulate, can lead to impaired health and performance. The goals of this study are to use digital health data to see if physiological measures, such as heart rate variability, and performance-based measures, such as mobile cognitive testing, can serve as indicators of accrued strain, which is often unobservable and hence easy to ignore. The ability to utilize real- world digital health data for the identification of strain will enable enhancement of existing, and creation of new, worker recovery interventions, which could prevent the negative effects of strain accumulation.

PI_NAMEs: HERNANDEZ, RAYMOND  (contact)

PROGRAM_OFFICER_NAME: LIOCE, MARIA

PROJECT_TITLE: Examining Potential Mobile Measures of Strain, or the Accumulated Effects of Exposure to Demands

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Endometriosis;Immunotherapy;Women's Health Research

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Endometriosis is a debilitating chronic disease characterized by an abnormal endometrial immune microenvironment, affecting 10% of reproductive-age women worldwide. The goal of this proposal is to gain a better understanding of the contribution of uterine natural killer cells, the dominant cytolytic lymphocyte in the endometrium, to endometriosis pathobiology and to identify non-invasive, mechanistically-driven diagnostic biomarkers in menstrual blood. Ultimately, completion of this work will contribute to significantly reducing the long diagnostic delay associated with endometriosis by unraveling fundamental immune mechanisms and expanding the pool of potential therapeutic targets, thereby mitigating the burden of illness and disability associated with this condition.

PI_NAMEs: FEYAERTS, DORIEN  (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TERMS: Activities of Daily Living;Affect;Age;Autologous;Biological Assay;Biological Markers;Biopsy;Biopsy Specimen;Blood;burden of illness;Career Choice;career development;case control;Cell Differentiation process;Cell Separation;Cell-Mediated Cytolysis;Cells;Cervical;Chronic Disease;Classification;Clinical Management;Computational Biology;cost effective;Cytolysis;Cytometry;cytotoxicity;Development;Diagnosis;diagnosis standard;Diagnostic;diagnostic biomarker;Diagnostic Procedure;differential expression;directed attention;disability;Disease;Disease stratification;Disparity;Dissociation;Endometrial;Endometrial Stromal Cell;endometriosis;Endometrium;Environment;Etiology;Exhibits;Formalin;Foundations;Functional disorder;Goals;high dimensionality;Human;Image;Immune;Immune response;Immunity;Immunoassay;Immunology;improved;innovation;insight;Laboratories;Laparoscopy;Ligands;Lymphocyte;machine learning method;Macrophage;Mediating;medical schools;Mentors;Messenger RNA;Modeling;Monitor;Natural Killer Cells;noninvasive diagnosis;Paraffin Embedding;Phagocytes;Phase;Phenotype;Play;predictive modeling;Proteins;Quality of life;receptor;reconstitution;Recurrence;reproductive;Reproductive Immunology;reproductive system disorder;Research;Research Training;Risk Assessment;Role;single-cell RNA sequencing;Source;Suspensions;Symptoms;System;Therapeutic;therapeutic development;therapeutic target;Tissues;Training;translational scientist;tumor-immune system interactions;Universities;Uterine Diseases;Uterus;Woman;Work

PROJECT_TITLE: Endometrial immune microenvironment dysfunction in endometriosis pathobiology


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pain Research;Pediatric;Telehealth

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Despite experiencing disabling chronic pain at similar rates as adolescents and older adults, there is limited research to inform interventions for this underserved age group. This project will define potent treatment targets using ecological momentary assessment and co-design with young adults to develop a personalized, adaptive mobile intervention for pain management. Knowledge gained can lead to a new generation of effective, accessible, and scalable digital health interventions for young adults, halting the escalation of pain, disability, and socioeconomic and health disparities in adulthood.

PI_NAMEs: MURRAY, CAITLIN  (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: adaptive intervention;Address;Adolescent;Adult;Affect;Age;age group;Anxiety;Behavioral;Breathing;career;Caring;Cellular Phone;Childhood;Chronic disabling pain;chronic pain;chronic pain management;clinical pain;Cognitive;Conduct Clinical Trials;contextual factors;Data;design;Development;digital;digital health;disability;Disabling;Ecological momentary assessment;Economic Burden;Effectiveness;Ensure;experience;Face;Generations;Goals;health disparity;Health Services Accessibility;human centered design;Improve Access;improved;Individual;innovation;Intervention;Knowledge;Location;Mental Depression;Mental disorders;Methodology;Methods;mHealth;mhealth interventions;mindfulness;mobile application;Mobile Health Application;Moods;negative mood;novel;Obesity;older adult;Outcomes Research;Pain;Pain Clinics;Pain management;Patients;personalized approach;poor sleep;Population;Population Intervention;Positioning Attribute;Protocols documentation;prototype;psychologic;Psychological Theory;Randomized;randomized trial;randomized, clinical trials;Research;Risk;Scientist;Severities;skills;Sleep;Sleep disturbances;smartphone application;Societies;socioeconomic disparity;substance use;Surveys;symptomatic improvement;tailored messaging;Testing;theories;therapy development;Time;Training;Training Activity;Treatment Efficacy;Vulnerable Populations;young adult

PROJECT_TITLE: Using ecological momentary assessment to develop an adaptive psychological intervention for young adults with chronic pain.

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (05)]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetic Testing;Genetics;Human Genome;Neurosciences;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE Glioblastoma is the most common primary malignant brain tumor in adults and remains fatal despite aggressive treatments. One of the main barriers to understanding glioblastoma tumor biology and developing more effective therapies is the dependence on tumor tissue obtained via invasive surgical procedures for diagnosis. This work will evaluate whether cell-free DNA methylation patterns derived from peripheral blood correlate with tumor biology and treatment response, thereby providing a method for longitudinal molecular profiling.

PI_NAMEs: VAIOS, EUGENE  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Adult;aggressive therapy;Apoptosis;Attention;Award;biobank;Biological;Biological Markers;Biopsy;Blood;Blood Cells;Blood specimen;Brain Injuries;Brain Neoplasms;cell free DNA;Cells;chemoradiation;chemotherapy;Classification;Clinical;Clinical Trials;Clinical Trials Design;cohort;cost;Data;Dependence;Detection;Development;Diagnosis;Diagnostic;Disease Surveillance;DNA;DNA Double Strand Break;DNA Methylation;effective therapy;Eligibility Determination;Encephalitis;Enrollment;Epidermal Growth Factor Receptor;Epigenetic Process;epigenomics;Feasibility Studies;Gene Frequency;Genes;genetic variant;Genomic DNA;Genomics;Germ-Line Mutation;Glioblastoma;Glioma;Goals;Heterogeneity;Image;Immune;immune activation;improved;Inflammation;Inflammatory;Inter-tumoral heterogeneity;Investigation;Isocitrate Dehydrogenase;Link;Lymphocyte;Magnetic Resonance Imaging;Malignant neoplasm of brain;Measures;Mesenchymal;Methods;Methylation;methylation pattern;MGMT gene;Modification;Molecular;Molecular Profiling;Mutation;Mutation Analysis;neoplastic cell;neutrophil;noninvasive diagnosis;novel;novel therapeutic intervention;O-(6)-methylguanine;Operative Surgical Procedures;Outcome;participant enrollment;Pathway interactions;Patient Recruitments;Patients;Pattern;Peripheral;peripheral blood;Phase;Population;Prediction of Response to Therapy;Prognostic Marker;Progression-Free Survivals;Proliferating;promoter;prospective;PTEN gene;Radiation;Radiation therapy;radiological imaging;Randomized;Recruitment Activity;Recurrence;Recurrent disease;Recurrent tumor;Research;response;Retrospective Studies;risk stratification;Sample Size;Sampling Errors;screening;Selection for Treatments;skills;Somatic Mutation;standard of care;Stimulator of Interferon Genes;temozolomide;Testing;Tissues;TP53 gene;treatment response;tumor;Tumor Biology;Tumor Burden;Tumor Cell Necrosis;tumor DNA;tumor heterogeneity;Tumor Markers;tumor microenvironment;Tumor Tissue;Whole Blood;Work

PROJECT_TITLE: Cell-Free DNA Methylation Patterns as a Biomarker for Tumor Biology and Clinical Outcomes for Glioblastoma Patients

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: BOZEMAN

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: Project Narrative Drawing from a national sample of cohabiting and married couples, the proposed project examines how romantic relationship characteristics are associated with alcohol use among sexual and gender minority (SGM) and cisgender straight adults. We also examine if romantic partnership characteristics help buffer against heavy alcohol use in the face of discrimination stressors among SGM couples. Expanding knowledge about how SGM couples thrive in antagonistic contexts will inform intervention programing and help reduce health disparities for this population.

PI_NAMEs: GREENE, KAYLIN  (contact)

PROGRAM_OFFICER_NAME: RUFFIN, BEVERLY

PROJECT_TERMS: Adult;aged;Alcohol abuse;alcohol consequences;Alcohol consumption;alcohol related problem;alcohol research;Alcohols;Area;assault;Attention;Attenuated;Behavior;Bisexual;Buffers;Cause of Death;Cessation of life;Characteristics;cisgender;coping;County;Couples;Data;Data Set;Discrimination;Disparity;Disparity population;disparity reduction;Distress;Drug usage;Emotional;Environment;Etiology;experience;Funding;Gays;Gender;gender minority group;Harm Reduction;Health;Health behavior;health disparity;health disparity populations;Heavy Drinking;Heterogeneity;Individual;Injury;innovation;insight;interdisciplinary collaboration;interest;Intervention;intervention program;Knowledge;Leadership;Lesbian;Lesbian Gay Bisexual Transgender;Link;Marriage;Measures;men;Modeling;multilevel analysis;multiple data sources;National Institute of Child Health and Human Development;National Institute on Alcohol Abuse and Alcoholism;National Institute on Minority Health and Health Disparities;Pattern;perceived discrimination;Persons;Policies;Population;Population Research;preventable death;Prevention;protective factors;Reduce health disparities;Research;Research Personnel;resilience factor;Respondent;Risk;Risk Factors;Role;Sampling;satisfaction;secondary analysis;Services;Sexual and Gender Minorities;sexual minority group;Shapes;social;social stigma;Spouses;Stress;stressor;substance use;Surveys;Testing;Time;Time Study;willingness;Woman;Work

PROJECT_TITLE: Romantic Relationships, Discrimination Stressors, and Alcohol Use among Sexual and Gender Minority Adults

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE  My recent work led to a discovery of perivascular retinal neurons, termed Fam19a4/Nts-RGCs, that selectively interact with vessels via perivascular endfeet. I further found that Piezo2, a mechanosensitive cation channel, is enriched in these perivascular neurons at the interface of neurovascular interactions. My proposed project will combine electrophysiology, experimental optic neuropathy models, single-cell profiling, and in vivo imaging to investigate Piezo2's role in modulating these newly characterized perivascular neurons' physiological properties and pathological responses.

PI_NAMEs: WANG, FEI  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Acute;adaptive optics;Affect;Amacrine Cells;Award;Behavior;Blood Vessels;Brain;career;Cations;cell assembly;Cell Communication;Cell Physiology;cell type;Cells;cellular resilience;Cellular Structures;Central Nervous System;cholinergic;Chronic;Collaborations;Collection;Data;Dendrites;detector;Electrodes;Electrophysiology (science);Endothelial Cells;Ensure;Exhibits;experimental study;Eye;feature detection;Feedback;Foundations;ganglion cell;Genetic;Glaucoma;Goals;imaging platform;imaging system;in vivo;in vivo imaging;in vivo imaging system;Individual;information processing;innovation;Interneurons;Intervention;Ischemia;Knowledge;Laboratories;Learning;Light;Link;Measurement;Measures;mechanical force;mechanical pressure;Mechanical Stimulation;Mediating;Mentors;Microglia;Modeling;Molecular;mutant;Nervous System Physiology;neurochemistry;Neuroglia;Neurologic;Neurons;neuroprotection;neurotransmission;neurovascular;novel;ocular imaging;optic nerve disorder;patch clamp;patch sequencing;Pathologic;Pathway interactions;Perfusion;Peripheral Nervous System;Pharmacology;Photic Stimulation;Physiologic Intraocular Pressure;Physiologic pulse;Physiological;Piezo 2 ion channel;post-doctoral training;pre-doctoral;pressure;presynaptic;programs;Property;Publications;Reagent;Research;Resolution;response;Response to stimulus physiology;Retina;Retinal Diseases;Retinal Ganglion Cells;retinal neuron;Risk Factors;Role;sensory stimulus;signal processing;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Solid;Specificity;starburst amacrine cell;Stereotyping;Stimulus;Structure;Synapses;System;Techniques;Temperature;Testing;Time;tool;Training;transcriptomics;transmission process;two-photon;Vascular Endothelial Cell;vasoconstriction;Vasodilation;Viral;Vision;vision development;Visual;visual stimulus;Work

PROJECT_TITLE: Defining Roles of Perivascular Retinal Neurons by Integrating Visual Stimuli and Vascular Tones

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (03)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: The consequences of weakness in the extremities, chronic pain, paralysis, and amputation can adversely affect a Veteran’s ability to work, to engage in activities, and to maintain a desired quality of life. Nerve stimulation coupled with advanced prosthetic technologies has shown the capability to restore some sensation in the lost limb and decrease phantom pain. Nerve stimulation is also emerging as a non-opioid treatment for acute and chronic pain. While the baseline technologies exist to provide the patient adequate treatment, optimal implanted devices will require a higher-density of connections from the nerve to the stimulator. Our proposed research will address this need in a manner that will also allow for a minimally invasive procedure and reduce the bulk of implanted material. This work will contribute to improvements in existing implanted nerve stimulation systems and will provide the opportunity for investigating new treatments to enhance Veterans’ lives.

PI_NAMEs: GBUR, JANET L (contact)

PROJECT_TERMS: Acute Pain;Adhesions;Aerosols;Affect;Amputation;Animals;Architecture;Biological;biomaterial compatibility;Biotechnology;Chronic;chronic pain;chronic pain management;Clinical;Complex;Computer-Aided Design;Core Facility;Coupled;Data;density;design;Development;Devices;Diameter;electric impedance;Electric Stimulation;Electrodes;Electronics;Ensure;Environment;Esthesia;Evaluation;experimental study;fabrication;Family Felidae;Fatigue;flexibility;Foundations;functional independence;Funding;Future;Implant;implant material;implantable device;implantation;Implantation procedure;improved;In Vitro;in vivo;Ink;Journals;Lead;limb loss;Limb structure;manufacture;manufacturing technology;Mechanics;Medical Device;metallicity;military veteran;miniaturize;minimally invasive;Modality;Monitor;motor control;nanoscale;Nerve;neural;neurological rehabilitation;neuroprosthesis;neurorestoration;neurotechnology;non-opioid analgesic;Nonpharmacologic Therapy;novel;Pain management;Paralysed;Partner in relationship;Patient Care;Patients;Performance;Periodicity;Peripheral Nerve Stimulation;Phantom Limb Pain;Power Sources;Preclinical Testing;preclinical trial;Printing;Procedures;process optimization;Prosthesis;prototype;Publishing;Quality of life;rehabilitation research;Rehabilitation therapy;Research;Research Personnel;Resistance;Resources;response;restoration;Sampling;Science;Series;Specimen;Spectrum Analysis;System;Technology;technology platform;Testing;Tissues;Translating;Trauma;Tube;Universities;Veterans;Work

PROJECT_TITLE: Development of Novel, Flexible Printed Lead Body for Use in Minimally Invasive Pain Management Systems

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ORG_CITY: HONOLULU

ORG_NAME: VA PACIFIC ISLANDS HEALTH CARE SYSTEM

ORG_STATE: HI

PHR: This project will evaluate neurofeedback, a type of biofeedback, training as a low risk, non-invasive, effective treatment for our Veterans who had a concussion(s) while at war serving in the military. Some Veterans, who experienced concussions, may suffer from some long-lasting health issues such as headaches, trouble paying attention, sleep difficulties and negative feelings about their life. These can negatively impact all aspects of life, including work, health, relationships, ability to do daily tasks and quality of life. Since neurofeedback, has been shown to help other people who had concussions, this study will examine whether neurofeedback will help our Veterans. Neurofeedback will be used to assist Veterans to self-regulate brain wave activity and stabilize the underlying physiological disconnections that may stem from concussions. Assisting Veterans to self-regulate brain wave activity through neurofeedback has the potential for significant positive changes in Veterans’ physical and mental health and their perceptions of self-health management and overall quality of life.

PI_NAMEs: CARLSON, JUDY M (contact)

PROJECT_TERMS: Achievement;Affect;Afghanistan;Aftercare;Anxiety;Area;Attention;Biofeedback;Brain;Brain Concussion;Brain Injuries;Chronic;Chronic Headaches;Clinical;Clinical Trials;clinically significant;comparison control;computerized;Control Groups;Data;design;Devices;Diagnosis;Disabling;Disease;effective therapy;emotional symptom;Enrollment;Evaluation;experience;Exposure to;Feedback;Feeling;follow-up;Freedom;Frequencies;group intervention;Headache;Health;health management;Hour;Impairment;improved;improvement on sleep;indexing;instrument;Intervention;Iraq;Life;Measures;member;Mental Depression;Mental Health;mild traumatic brain injury;Military Personnel;neurofeedback;Neuronal Plasticity;operation;Outcome;Patient Self-Report;Patients;Perceived quality of life;Perception;performance tests;persistent symptom;Personal Satisfaction;Persons;physical conditioning;physical symptom;Physiological;post intervention;Post-Concussion Syndrome;Post-Traumatic Stress Disorders;Process;Psyche structure;Quality of life;Questionnaires;Randomized;Rehabilitation therapy;Research Design;Risk;Role;Sampling;satisfaction;Self Perception;Severities;simulation game;Sleep;sleep difficulty;Sleep disturbances;sleep quality;Sleeplessness;standard care;stem;Stress;success;Symptoms;tool;Training;Traumatic Brain Injury;treatment as usual;treatment group;treatment strategy;Veterans;Visual attention;War;Work

PROJECT_TITLE: Neurofeedback Impact on Chronic Headache, Sleep and Attention Disorders Experienced by Veterans with Mild Traumatic Brain Injury.


ADMINISTERING_IC: OD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative This proposal seeks to develop a cell-cell mRNA delivery platform to express therapeutic payloads to address diseases. This platform will have broad applications, including: 1) correcting disease causing mutations using gene editing, 2) inducing cell killing in diseased cell types like cancer and 3) reprogramming cell states to replace lost cell types in diseases like type 2 diabetes.

PI_NAMEs: TOBIN, VICTORIA ROSE (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Address;Biological Assay;burden of illness;Bypass;cancer cell;Capsid Proteins;Caspase;Cell Death Induction;cell killing;Cell Line;Cell Reprogramming;Cell Therapy;cell type;Cells;clinically relevant;delivery vehicle;Disease;disease-causing mutation;Elements;engineered T cells;Engineering;Ensure;epidermal growth factor receptor VIII;ERBB2 gene;Gene Mutation;Genes;genome editing;Goals;Home;Human;Immune;immunoengineering;Immunosuppression;In Vitro;in vivo;in vivo Model;K-562;Logic;Malignant Neoplasms;Measures;Messenger RNA;Methods;mouse model;mRNA delivery;mRNA Export;Mus;neoplastic cell;Non-Insulin-Dependent Diabetes Mellitus;novel;particle;Pathogenicity;Patients;Population;Production;Protein Engineering;protein expression;Proteins;receptor;Regional Disease;RNA;RNA-Binding Proteins;sensor;Specificity;Surface Antigens;System;T-Lymphocyte;Testing;Therapeutic;Therapeutic Agents;therapeutic protein;Tissues;Transfection;tumor;Viral;Work

PROJECT_TITLE: Targeted cell-to-cell mRNA delivery of therapeutic circuits

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Bioengineering;Biomedical Imaging;Brain Disorders;Childhood Injury;Clinical Research;Emergency Care;Health Services;Neurosciences;Patient Safety;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: PROJECT NARRATIVE This project investigates the accuracy and feasibility of using point-of-care, low-field brain magnetic resonance imaging (POC LF-MRI) for diagnosing traumatic brain injury (TBI) in children, a population vulnerable to the harmful ionizing radiation of traditional CT scans. Through a comprehensive, observational cohort study, we aim to compare the accuracy of POC LF-MRI against the current standard of care, assess its capability to track injury progression, and evaluate its practical metrics in emergency and critical care settings. Our goal is to determine if POC LF-MRI can provide accurate, efficient, and more accessible neuroimaging, potentially redefining pediatric trauma care while reducing ionizing radiation risks and enhancing patient safety.

PI_NAMEs: CHAUDHARI, PRADIP  (contact);LEPORE, NATASHA

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: 17 year old;Accident and Emergency department;Accounting;Acute;acute care;Adoption;age group;Brain;brain magnetic resonance imaging;cancer risk;Caring;Cessation of life;Child;Child Care;Child health care;Childhood;Childhood Injury;Clinical;cost effective;Craniocerebral Trauma;Critical Care;Diagnosis;diagnostic accuracy;Diagnostic tests;disability;Disadvantaged;Distant;Edema;Emergency Care;Emergency department visit;Equity;Evaluation;Expert Systems;Exposure to;follow-up;Fracture;Future;Goals;hazard;Health;Health Care Costs;Hemorrhage;Hospitalization;Image;improved;Injury;innovation;Intensive Care Units;Intervention;Intratracheal Intubation;Ionizing radiation;Knowledge;Length of Stay;Life;magnetic field;Magnetic Resonance Imaging;Measurable;Measures;member;Modality;Modernization;Monitor;Morbidity - disease rate;mortality;multidisciplinary;neuroimaging;neurosurgery;observational cohort study;Outcome;patient safety;Patients;pediatric patients;pediatric trauma;point of care;portability;prospective;Protocols documentation;Radiation;Radiation Dose Unit;Radiation exposure;radiation risk;Research;Risk;Risk Assessment;risk stratification;Safety;Scanning;Sedation procedure;severe injury;Signs and Symptoms;Skull Fractures;standard of care;System;Time;trauma care;Trauma patient;Traumatic Brain Injury;user-friendly;Vulnerable Populations;Work;X-Ray Computed Tomography

PROJECT_TITLE: Point-of-Care Brain Magnetic Resonance Imaging in Children with Head Trauma (BRAINCHILD)

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Services;Infectious Diseases;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Telehealth

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Aligned with NIH's priority of supporting the development of innovative mobile health applications to improve clinical and public health outcomes and strengthen research capacity in low- and middle-income countries, the proposed Suubi-Mhealth study seeks to develop an mhealth intervention for use among Ugandan youth (14-17 years) with comorbid HIV and depression, taking into account their unique contextual, cultural, and developmental needs. This digital therapy intervention delivered via a mobile application, will utilize the core tenets of cognitive-behavioral therapy (CBT) found to improve depression and ART adherence. We expect for Suubi-Mhealth to be an acceptable and feasible mhealth tool to reduce depression, improve ART adherence and overall mental health functioning among youth living with HIV.

PI_NAMEs: CAVAZOS-REHG, PATRICIA A;MUGISHA, JAMES ;NABUNYA, PROSCOVIA  (contact)

PROGRAM_OFFICER_NAME: BEKALU, MESFIN AWOKE

PROJECT_TERMS: 15 year old;acceptability and feasibility;active method;Address;Adherence;Adolescent;Adult;Africa South of the Sahara;Age;antiretroviral therapy;Behavior Therapy;behavioral health;Caregivers;Cellular Phone;Child;Clinic;Clinical;Cognitive Therapy;comorbidity;Control Groups;Depressed mood;depressive symptoms;Development;digital treatment;Drops;Evaluation;evidence base;Evidence based intervention;experience;Feedback;Focus Groups;Goals;Health;health care settings;Health Personnel;HIV;HIV Infections;improved;innovation;Intervention;intervention effect;intervention refinement;Interview;Lead;Letters;low and middle-income countries;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methodology;Methods;mHealth;mhealth interventions;mobile application;Mobile Health Application;Outcome;Persons;Phase;pilot test;post intervention;Practical Robust Implementation and Sustainability Model;Prevalence;primary outcome;programs;Protocols documentation;Public Health;Quality of life;recruit;Research;Resource-limited setting;response;Risk;Sampling;secondary outcome;Signal Transduction;Site;social stigma;Specific qualifier value;Structure;Subgroup;success;Testing;Therapeutic Intervention;therapy adherence;Time;tool;transmission process;treatment adherence;Uganda;United States National Institutes of Health;user centered design;Waiting Lists;Work;young adult;Youth

PROJECT_TITLE: Suubi-Mhealth: A mobile health intervention to address depression and  improve ART adherence among Youth living with HIV (YLHIV) in Uganda

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-J(56)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Teenage Pregnancy;Telehealth;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative In order to promote an optimal transition into adulthood, innovative solutions to prevent HIV infection and unintended pregnancy are needed among adolescent girls and young women in high HIV prevalence low- and middle-income countries. We propose to co-design and test a novel peer-navigator intervention, facilitated by an mHealth application, to increase pre-exposure prophylaxis and modern contraception use among a high-risk sub-population of young women in Zambia. The mHealth intervention has the potential to provide a model for scale-up across other sub-Saharan African settings and significantly reduce the burden of HIV and unintended pregnancy among adolescent girls and young women.

PI_NAMEs: HAMPANDA, KAREN MARIE (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Africa South of the Sahara;African;age group;aged;AIDS prevention;arm;authority;Awareness;Behavioral;Behavioral Mechanisms;Biological Factors;Caring;Cause of Death;Clinic;Communication;Contraceptive Agents;Contraceptive Availability;Contraceptive methods;Contraceptive Usage;Counseling;Country;Data;design;Education;effectiveness evaluation;Effectiveness of Interventions;effectiveness-implementation RCT;Ensure;Event;experience;Face;Female;Female Adolescents;follow-up;Future;Government;Health;health belief;health service use;high risk;High Risk Woman;high-risk adolescents;HIV;HIV Infections;HIV-infected adolescents;human centered design;Hybrids;implementation determinants;implementation evaluation;improved;innovation;Intention;Intervention;Interview;Investments;Knowledge;Lesotho;Level of Evidence;Life;Life Change Events;Link;low and middle-income countries;Low Prevalence;Mediation;member;Methods;mHealth;mhealth interventions;Mobile Health Application;Modeling;Modernization;mortality;navigator intervention;neglect;Notification;novel;Oral;Outcome;Outcome Study;Participant;Pathway interactions;peer;peer support;Perception;Performance;Phase;Population;pre-exposure prophylaxis;Predisposition;preference;Pregnancy;Pregnancy Complications;prevent;Prevention;primary outcome;programs;prospective;Public Health;Qualitative Methods;Quality of life;randomized trial;Recommendation;reproductive;Reproductive Health;reproductive health intervention;Reproductive Health Services;reproductive outcome;Research;Risk;Running;scale up;secondary outcome;Self Efficacy;service delivery;Services;sexual and reproductive health;Site;social;social factors;social stigma;structural determinants;Students;Surveys;Tablets;Testing;theories;tool;transition to adulthood;unintended pregnancy;Universities;university student;uptake;Visit;young woman;Zambia

PROJECT_TITLE: mHealth Intervention to Increase Uptake of Contraception and PrEP Among Female University Students in Zambia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-K(55)R]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_DEPT: OTOLARYNGOLOGY

PHR: PUBLIC HEALTH RELEVANCE Chronic cough that does not respond to standard cough treatments (known as refractory chronic cough) is highly disruptive and significantly reduces well-being. The proposed studies will lay the groundwork for a larger clinical trial of the use of vibrotactile stimulation to the larynx to reduce refractory chronic cough via dose refinement (Aim 1) and conduct of a pilot randomized clinical trial (Aim 2). This potential treatment is noninvasive, repeatable, independently usable, and portable, making it a promising option for improving the quality of life of people who suffer from refractory chronic cough.

PI_NAMEs: MISONO, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: acceptability and feasibility;Adherence;Adverse event;Affect;Air;Anterior;Area;Asthma;base;Behavioral;Biometry;Caring;Chronic;chronic pain;Clinic;Clinical;Clinical Trials;cost;Coughing;Data;design;Devices;Disease;Dose;effective therapy;eligible participant;Enrollment;Equilibrium;Etiology;Feedback;Fibromyalgia;Gastroesophageal reflux disease;Goals;Health;Health Services Accessibility;Healthcare Systems;Hypersensitivity;improved;Individual;insight;Interdisciplinary Study;interest;irritation;Larynx;Link;Literature;Lung Diseases;Measures;Medical;Medical Device;medical specialties;Mission;mobile application;Motor;Motor Cortex;multidisciplinary;National Heart, Lung, and Blood Institute;Neck;Neuropathy;neuroregulation;novel;novel therapeutic intervention;Occupational;Outcome;Participant;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;Physiology;Play;portability;primary outcome;Productivity;Provider;public health relevance;Pulmonology;Quality of life;Questionnaires;Randomized;randomized, clinical trials;Randomized, Controlled Trials;reduce symptoms;Refractory;Regimen;Reporting;Resources;Role;secondary outcome;Sensory;sensory input;Series;Severities;side effect;Skin;social;somatosensory;Spasm;Spastic Dysphonias;standard care;Stimulus;Structure;Symptom Burden;Symptoms;Testing;timeline;usability;vibration;vibrotactile stimulation;Visit;vocal cord

PROJECT_TITLE: Vibrotactile stimulation of the larynx for refractory chronic cough

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT (MA)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Nutrition;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Relapse is a leading cause of death in pediatric acute myeloid leukemia (AML), and new therapies are needed for relapsed disease. AML relapse is mediated by leukemia stem cells (LSC), which undergo unique metabolic adaptations in order to survive chemotherapy. Emerging evidence shows that LSC require lipid metabolism to mediate relapse. The purpose of this work is to determine how lipid metabolism supports LSC mitochondria and the process of oxidative phosphorylation. This will be done by studying lipid metabolism in AML cell lines as well as using a high-fat diet to drive AML relapse in mice engrafted with pediatric AML. If successful, this work will improve our understanding of AML biology by providing a mechanistic explanation for the ways in which lipids support LSC during relapse.

PI_NAMEs: ZACHMAN, DEREK  (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Adipose tissue;Biology;Body mass index;burden of illness;Candidate Disease Gene;Carbon;career development;Cause of Death;Cell Line;Cells;Chemoresistance;chemotherapy;Childhood Acute Myeloid Leukemia;Clinical;Data;Data Set;Databases;design;Development Plans;Diagnosis;effective therapy;Engraftment;Ensure;Environment;experience;experimental study;fatty acid oxidation;Fatty Acids;Fellowship;Future;Gene set enrichment analysis;Genes;Genetic Transcription;Glucose;Goals;Growth;Hematology;Heme;heme biosynthesis;High Fat Diet;immunodeficiency;improved;In Vitro;in vivo;Institution;Isotopes;knock-down;leukemia;leukemia relapse;leukemia treatment;leukemic stem cell;Link;lipid metabolism;Lipids;Malignant Childhood Neoplasm;Mediating;Mentors;Metabolic;Metabolism;metabolomics;Mitochondria;Molecular;mouse model;Mus;new therapeutic target;novel;novel therapeutics;nutrition;Oncology;Outcome;Oxidative Phosphorylation;Oxidative Regulation;Palmitates;patient derived xenograft model;Patients;Pediatric cohort;Pediatric Hematology;pediatric patients;Phosphorylation;Physicians;Physiology;preference;Process;programs;Property;protein complex;Proteins;Proteome;Proteomics;Recurrent disease;Relapse;Research;Research Personnel;Resources;RNA Interference;Role;Running;Saint Jude Children's Research Hospital;Scientist;Source;stable isotope;stem cell biology;success;Survival Rate;targeted treatment;Testing;Therapeutic;Time;Training;transcriptome sequencing;translational potential;Transplantation;uptake;Work;Xenograft procedure

PROJECT_TITLE: Metabolic regulation of oxidative phosphorylation in pediatric AML relapse


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Behavioral disorders that have a strong social component, such as autism spectrum disorders, are often more common and severe in males than in females. Sexual differentiation of the brain likely contributes to these differences. This research explores the behavioral consequences of sex differences in neural systems implicated in social behavior.

PI_NAMEs: DE VRIES, GEERT J. (contact);PETRULIS, ARAS T

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Ablation;Acute;Adult;Affect;Amygdaloid structure;Anatomy;autism spectrum disorder;Behavior;Behavior Disorders;Behavioral;Brain;brain control;CASP3 gene;Cell Physiology;Cells;Data;designer receptors exclusively activated by designer drugs;Enterobacteria phage P1 Cre recombinase;Excision;Female;Foundations;Functional disorder;Genetic;genetic approach;Grant;Human;Injections;interest;knock-down;Laboratories;male;mature animal;Medial;Morbidity - disease rate;Mus;nerve supply;neural;neural circuit;Neurons;neuroregulation;Neurotransmitters;Output;pharmacologic;Play;prevent;Production;Research;Rodent;Sex Differences;Sex Differentiation;sexual dimorphism;social;Social Behavior;Social Behavior Disorders;social communication;Social Controls;Steroids;Structure of terminal stria nuclei of preoptic region;System;Testing;theories;tool;Tracer;Translating;Vasopressins;vector control;Vertebrates;Viral Vector;women versus men;Work

PROJECT_TITLE: Sex Differences in the Neural Control of Social Behavior

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: MILWAUKEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN MILWAUKEE

ORG_STATE: WI

PHR: PROJECT NARRATIVE This study aims to examine whether the proposed computerized cognitive training program can improve the neural indicators of the ability to inhibit inappropriate responses, and produce a clinically meaningful level of reduction in obsessive-compulsive disorder and related symptoms. This project is expected to generate valuable knowledge to guide the development of an effective, personally-optimizable, theoretically-sound, and portable computerized intervention that can be applied to numerous clinical problems characterized by the poor ability to inhibit inappropriate responses, yielding significant public health impact.

PI_NAMEs: LARSON, CHRISTINE L;LEE, HAN JOO  (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Adult;Adverse effects;Attention deficit hyperactivity disorder;Basal Ganglia;Behavior monitoring;Behavior Therapy;Behavioral;behavioral impairment;behavioral response;Binge Eating;Brain;Clinical;clinical practice;Cognitive;cognitive control;cognitive process;cognitive training;comparison group;computerized;confirmatory trial;cost efficient;Data;design;Development;Diagnostic;Disease;dosage;Dose;Educational Intervention;effectiveness evaluation;efficacious treatment;Electrophysiology (science);endophenotype;Failure;follow-up;frontal lobe;functional outcomes;Goals;Impairment;improved;indexing;Individual;Inferior;innovation;Intervention;Knowledge;Link;Literature;Measures;Mediating;Monitor;neural;neurobehavioral;Neurocognitive Deficit;neuroimaging;neuromechanism;novel;Obsessive compulsive behavior;Obsessive-Compulsive Disorder;Outcome;Participant;patient subsets;Patients;Performance;personalized medicine;Pharmacological Treatment;Phase;Placebos;portability;post intervention;Process;Provider;Public Health;Randomized;randomized, clinical trials;reduce symptoms;remediation;Research;Research Domain Criteria;response;Skin;sound;Specific qualifier value;Specificity;stem;Substance Use Disorder;success;symptomatology;Symptoms;System;Therapeutic;therapy design;Training;Training Programs;Translating;treatment responders;Trichotillomania

PROJECT_TITLE: Neural Mechanisms of Response Inhibition Training for Obsessive-Compulsive Disorder and Related Conditions


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: LEXINGTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE The Quantitative Team Science (QuanTS) Program will provide training and mentorship in collaborative skills to equip quantitative scientists to work effectively on research teams across all fields of medicine. To accomplish this goal, we will create online didactic training materials that are broadly accessible to the quantitative science community, facilitate an experiential, small-group mentorship program focused on team science skills for early-career quantitative scientists, and provide guidance and training materials for mentors. We will also integrate novel evaluation processes within the program to examine facilitators, barriers and outcomes of the proposed methods for training and mentoring quantitative team scientists.

PI_NAMEs: POMANN, GINA-MARIA ;SLADE, EMILY  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-V (IP)]


NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE: Down syndrome is the world’s leading cause of intellectual disability. Proposed studies will use Down syndrome (Trisomy21)-human embryonic stem cell-derived neurons to model neurologic defects. This will yield molecular mechanistic insights into dysfunction, that eventually will provide therapeutic targets to reduce neurologic compromise in individuals born with Down syndrome.

PI_NAMEs: SMITH, GARY DANIEL (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Alzheimer's Disease;Aneuploidy;Animal Model;autism spectrum disorder;autosome;Axon;Behavioral;Biological Models;Birth;Brain;Brain Diseases;Cardiac;Cell Line;Cell model;Chromosome 21;Clinical;Cognitive;cognitive ability;Complex;Congenital Abnormality;Congenital chromosomal disease;craniofacial;Defect;Development;directed differentiation;Disease;dosage;Down Syndrome Cell Adhesion Molecule;Down's Syndrome;Drosophila genus;Early Onset Alzheimer Disease;effective therapy;Epilepsy;Exhibits;experience;Frequencies;Functional disorder;GABA Antagonists;Genes;Genetic;Genetic study;Goals;hippocampal pyramidal neuron;Human;Human Chromosomes;human embryonic stem cell;Human Genetics;human induced pluripotent stem cells;human model;human stem cells;Immunologics;Impairment;Individual;Inhibitory Synapse;insight;Intellectual functioning disability;Interneurons;Knowledge;Link;male;Materials Testing;Memory;memory recognition;Modeling;Molecular;Morphology;mouse model;Mus;Neocortex;nerve supply;Nervous System Disorder;Neurodegenerative Disorders;Neurodevelopmental Disorder;neurogenesis;Neurologic;Neurological Models;neuron development;neuronal cell body;Neuronal Dysfunction;Neurons;object recognition;overexpression;Pathogenesis;Pathology;Patients;Physiological;postsynaptic;Presynaptic Terminals;prevent;Proteins;Severities;spatial memory;stem cell model;stem cells;Structure;Study models;Synapses;Synaptic plasticity;Synaptic Transmission;synaptogenesis;System;Testing;therapeutic development;therapeutic target;Trinucleotide Repeats;Trisomy;United States National Institutes of Health;Variant

PROJECT_TITLE: Human Embryonic Stem Cell Models for Studying Mechanisms Underlying Changes In Inhibitory Synapses in Down Syndrome

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cardiovascular;Fentanyl Misuse and Addiction;Opioid Misuse and Addiction;Opioids;Substance Misuse;Wound Healing and Care

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Relevance to Public Health. Fentanyl and xylazine drugs are responsible for an ever increasing number of drug overdose deaths in the United States. Our studies will provide a better understanding of how and why these drugs cause illness and death; and, in the long- term, may lead to improved therapies for preventing and treating overdose.

PI_NAMEs: COTTEN, JOSEPH F (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Adrenergic Agonists;Adult;Anesthetics;Animals;base;Blood Gas Analysis;Blood Pressure;Body Temperature;Bradycardia;Breathing;Brown Fat;Cause of Death;Cessation of life;Chronic;Conscious;Dexmedetomidine;Dorsal;Dose;Electromyography;Female;Fentanyl;Gastrocnemius Muscle;genioglossus muscle;Heart Rate;hemodynamics;Human;Hypotension;Impaired wound healing;Impairment;Implant;improved;induced hypothermia;infection rate;Injections;Intravenous;intravenous drug user;male;Measures;Medical;Metabolism;Muscle Rigidity;natural hypothermia;Nose;Opioid;opioid use;Overdose;overdose death;Pharmaceutical Preparations;Physiologic Thermoregulation;Plethysmography;prevent;Public Health;Rattus;Receptors, Adrenergic, alpha-2;Rodent;Sedation procedure;sedative;Skeletal Muscle;skin wound;synthetic opioid;Tail;Telemetry;Temperature;Testing;Thermogenesis;Thermography;Thick;Toxic effect;United States;vasoconstriction;Ventilatory Depression;wound healing;Wound Infection;Wound models;Xylazine

PROJECT_TITLE: Xylazine and fentanyl effects on rat breathing, metabolism, and thermoregulation

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: EAST LANSING

ORG_DEPT: CHEMISTRY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Neurodegenerative diseases, including Alzheimer’s disease (AD) and Alzheimer’s disease related dementias (ADRD) are characterized by accumulation of intrinsically disordered proteins (IDPs) and impairment of proteasome-mediated protein degradation. This R36 proposal aims to investigate small molecule 20S proteasome activation as a novel strategy to resolve both pathogenic events. Successful completion of this work will enable the rapid design, development, and identification of 20S proteasome activators, and elucidate the role of 20S proteasome modulation in neurodegenerative diseases as a novel therapeutic strategy for disease treatment.

PI_NAMEs: COLOMBANI-GARAY, DANIEL JOSE (contact)

PROGRAM_OFFICER_NAME: COGLIATI, TIZIANA PAOLA

PROJECT_TERMS: alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-Protein;analog;Binding;Biological Assay;Chemicals;Complex;Cryoelectron Microscopy;cytotoxic;Data;Derivation procedure;design;Development;Diazomethane;Disease;Disease Progression;Docking;Enhancers;Event;Human;Impairment;improved;insight;Libraries;Ligands;Mass Spectrum Analysis;Mediating;Modeling;Molecular;molecular dynamics;multicatalytic endopeptidase complex;Neurodegenerative Disorders;neurotoxicity;novel;novel strategies;novel therapeutic intervention;Pathogenicity;Peptide Hydrolases;phosphoneuroprotein 14;Photoaffinity Labels;prevent;Production;protein degradation;protein oligomer;Proteins;Proteolysis;Regulation;restoration;Role;scaffold;screening;Series;Signal Transduction;small molecule;Surface Plasmon Resonance;symptom management;synuclein;Therapeutic;Time;Work

PROJECT_TITLE: Development of N-acyl fluspirilene mediated proteasome enhancement for the treatment of neurodegenerative diseases

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cardiovascular;Fentanyl Misuse and Addiction;Lung;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed exploratory studies are specifically relevant to a recent public safety alert issued by the DEA and DOJ regarding the enhanced lethality of fentanyl when co-administered with xylazine. The proposed research will systematically evaluate the dose/response for toxic side effects of each drug individually and in combination to define interactions and potentially identify actionable clinically relevant endpoints to improve outcome.

PI_NAMEs: HEERDT, PAUL MARK (contact)

PROGRAM_OFFICER_NAME: LE, HOANG VAN

PROJECT_TERMS: Acceleration;Acidosis;Anesthesia procedures;Animal Model;Animals;Biochemical;Blood;Blood flow;blood perfusion;Blood Pressure;blood pressure reduction;Brain;Cardiac Output;cardiovascular effects;cardiovascular pharmacology;Cardiovascular Physiology;Cardiovascular system;cerebral autoregulation;Cerebrum;Cessation of life;Chemosensitization;Clinical;clinically actionable;clinically relevant;Compensation;Critical Illness;Data;depressive symptoms;Dose;drug clearance;Exhibits;experience;Experimental Models;experimental study;Family suidae;Fentanyl;fentanyl overdose;Goals;Heart;heart function;Heart Rate;Hepatic;Homeostasis;Human;Hypercapnia;Hypoventilation;Hypoxemia;Hypoxia;illicit opioid;Impairment;improved outcome;Incidence;Individual;innovation;insight;interest;Intervention Studies;Intravenous;intravenous administration;Kinetics;Knowledge;Left;Liver;Mental Depression;Metabolic;Modeling;Monitor;mortality;National Institute of Drug Abuse;novel therapeutic intervention;Opioid;Opioid Receptor;Organ;Outcome;Overdose;overdose death;Oxygen;Patients;Perfusion;Pharmaceutical Preparations;Pharmacodynamics;Pharmacology;Physiological;Play;Poisoning;Probability;Property;public health relevance;Publishing;Receptors, Adrenergic, alpha-2;Reporting;Research;respiratory;Respiratory physiology;response;Safety;Secondary to;sedative;Self Administration;Series;side effect;Time;Tissues;Toxic effect;Translational Research;ventilation;Ventilatory Depression;Writing;Xylazine

PROJECT_TITLE: Cardiorespiratory Pharmacodynamics of Fentanyl-Xylazine

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Contraception/Reproduction;Infectious Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: OMAHA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE Annually, in the US, the treatment costs of chlamydial genital infections exceed 700 million dollars. Chlamydia grows within a pathogen-specified vacuole, the inclusion, within host cells. This proposal describes innovative approaches that examine specific mechanisms associated with limiting host cell stress to infection.

PI_NAMEs: RUCKS, ELIZABETH ANN (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Affect;Affinity Chromatography;Age;Amino Acids;Antibiotic Therapy;Area;Attention;Bacterial Vaginosis;Binding;Cells;Cellular Stress;Centrosome;Cervical;Chlamydia;Chlamydia Infections;Chlamydia trachomatis;Cholesterol;Cholesterol Homeostasis;Clathrin;Clathrin Adaptors;Cytoplasm;Data;Development;Dislocations;Ectopic Pregnancy;Endometrial;Endoplasmic Reticulum;Endosomes;Epithelial Cells;Equilibrium;Exocytosis;experimental study;Female of child bearing age;Gatekeeping;genital infection;Golgi Apparatus;Homeostasis;Host Defense Mechanism;Image;Immune system;improved;In Transferrin;Infection;Infertility;innovation;Intercept;Iron;knock-down;Label;Laboratories;Life Style;Link;lipid transport;Literature;Lysosomes;macrogolgin;Mass Spectrum Analysis;Mediating;Membrane;novel;Nutrient;Organelles;Organism;pathogen;Pathogenesis;Pathway interactions;Patients;Pelvic Inflammatory Disease;Phase;Phosphatidylinositols;Play;Positioning Attribute;Post-Translational Protein Processing;prevent;Proteins;receptor recycling;recruit;Recycling;reproductive system disorder;Risk;Role;Second Pregnancy Trimester;Signal Transduction;Site;Small Interfering RNA;SNAP receptor;Source;Specific qualifier value;Sphingomyelins;Spontaneous abortion;Stress;Structure;success;syntaxin;syntaxin 6;System;targeted treatment;Testing;TFRC gene;trafficking;trans-Golgi Network;Transferrin;transmission process;Treatment Cost;tubal infertility;Vacuole;vaginal microbiota;Vesicle;Woman;Women's Health

PROJECT_TITLE: Chlamydia trachomatis manipulates (PI)CALM to carry on

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]