ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Mental Health;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE This project will investigate the impact of prenatal exposures to complex mixtures of chemical and non-chemical stressors on key child health outcomes. It will also explore whether a healthy maternal diet during pregnancy can lessen the impact of these stressors on the child. This solution-oriented approach takes into account the complexity of real-world exposures and has strong potential to influence programs designed to improve children’s health.

PI_NAMEs: SCHANTZ, SUSAN L (contact)

PROJECT_TERMS: Address;anogenital distance;autism spectrum disorder;Award;Benzophenones;Birth;Birth Weight;Chemical Exposure;Chemicals;Child;Child Health;Cognition;Cognitive;cognitive development;cognitive function;cohort;Communities;community advisory board;community engagement;Complex Mixtures;Conceptions;Consumption;Creativeness;Data;Data Collection;design;Development;developmental disease;Diet;Dietary Component;Discrimination;Enrollment;ethnic diversity;Ethnic Origin;Exposure to;Federally Qualified Health Center;Feedback;Focus Groups;Gestational Age;Goals;good diet;Health;Healthcare;Illinois;improved;Incentives;Income;indexing;Individual;infancy;interest;Language Delays;Language Development;Low income;Low Income Population;maternal stress;mathematical ability;Measures;Methods;Modeling;Modification;mother nutrition;neurodevelopment;novel;novel strategies;Outcome;Paper;Participant;patient oriented;Pediatric cohort;perceived stress;perinatal outcomes;Phase;Phenols;phthalates;Pilot Projects;Poly-fluoroalkyl substances;Population Heterogeneity;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;prenatal stress;programs;Protocols documentation;Psychosocial Stress;Public Health;Race;racial diversity;reading ability;recruit;Reporting;Reproductive Health;Reproductive system;retention rate;School-Age Population;Schools;Science;Series;Stress;Stressful Event;stressor;Structure;success;Systems Development;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: The Illinois Kids Development Study ECHO Pregnancy and Pediatric Cohort


ADMINISTERING_IC: OD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Complementary and Integrative Health;Congenital Structural Anomalies;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Nutrition;Pediatric;Pregnancy;Prevention;Social Determinants of Health

ORG_CITY: DAVIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative The proposed work will address innovative research questions regarding unresolved disparities in periconceptional folate status and associations with downstream child health, exposures to novel plasticizing chemicals and other environmental exposures in relation to later child neurodevelopmental outcomes, interactions between these prenatal exposures, and potential intermediary epigenetic and biologic pathways. This work will help us to understand how factors could be modified to improve health outcomes of children, as well as identify the sub-populations of expecting families that might benefit most from preventive measures that can move us towards reducing the burden of neurodevelopmental disorders and improve the quality of life for children, with direct implications for clinical guidelines and public health recommendations.

PI_NAMEs: SCHMIDT, REBECCA JEAN (contact)

PROGRAM_OFFICER_NAME: MASH, CLAY

PROJECT_TERMS: Address;Affect;Age;Assessment tool;Attention deficit hyperactivity disorder;Attenuated;autism spectrum disorder;autism symptoms;Behavior;Behavioral;behavioral outcome;Biological;Blood;California;Chemicals;Child;Child Behavior Checklist;Child Health;Clinical;Clinical assessments;cohort;Communities;community engagement;Community Outreach;community partners;Conceptions;Data;Development;Developmental Delay Disorders;Disparity;Dose;Educational Activities;Ensure;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Pollutants;Epigenetic Process;Ethnic Origin;executive function;experience;Exposure to;Family;First Pregnancy Trimester;flexibility;Folic Acid;folic acid supplementation;Food;Fortification;Genetic;Grain;Guidelines;Health;Health Policy;Heavy Metals;high risk;Hispanic Populations;improved;in utero;innovation;Intake;Intervention;language outcome;Link;Measures;Mediating;Modified Checklist for Autism in Toddlers;Neural Tube Defects;Neurodevelopmental Disorder;novel;Nutritional;nutritional epidemiology;Outcome;Participant;Pathway interactions;people of color;perceived discrimination;personal care products;Persons;Placenta;Plasticizers;Policies;Population Heterogeneity;pregnant;prenatal;prenatal exposure;Prevalence;Preventive measure;Problem behavior;programs;Protocols documentation;Psychosocial Stress;Public Health;Quality of life;Race;racial diversity;randomized trial;Recommendation;recruit;reproductive epidemiology;Research;Resources;Risk;Shapes;Site;social;Social Functioning;socioeconomics;Subgroup;success;trait;Translations;Underrepresented Populations;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Prenatal Environment And Child Health (PEACH) in ECHO

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: FLUSHING

ORG_DEPT: PSYCHOLOGY

ORG_NAME: QUEENS COLLEGE

ORG_STATE: NY

PHR: Public Health Relevance The study will test the effects of in utero exposures to a natural disaster (hurricane Superstorm Sandy) in an intact cohort, whom we have followed since pregnancy. The study will help us chart the course of behavioral and neurodevelopmental outcomes from in utero to early adolescence as potential risk together with postnatal stress for future psychiatric and substance use disorders and determine whether specific epigenetic signatures within the placenta relate to offspring outcomes.

PI_NAMEs: NOMURA, YOKO  (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: 13 year old;Acceleration;addiction;Adolescence;Adrenal Glands;Adverse effects;Affect;Age;Aggressive behavior;Anxiety;ATAC-seq;Attention;Behavior;Behavior Disorders;Behavioral;behavioral outcome;behavioral phenotyping;biobank;biobehavior;Biological;biomarker identification;Birth;boys;Brain;Characteristics;Child;Child Behavior;Child Development;Child Rearing;Childhood;Chromatin;Clinic;Cognitive;cognitive development;cognitive function;cohort;Cohort Studies;cost;Data;dehydroepiandrosterone;demographics;Development;Dimensions;Discipline of obstetrics;Disease;early adolescence;early childhood;early onset substance use;emotion dysregulation;Emotional;Environment;Epigenetic Process;epigenome;excessive anxiety;Executive Dysfunction;executive function;Exposure to;fetal programming;Fright;Future;Gene Expression;gene network;Genes;Genetic;Genetic Transcription;girls;Goals;Hair;Health;high risk;Hurricane;Hydrocortisone;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Immune;Immune system;Impulsivity;in utero;Incidence;Individual Differences;infancy;Intervention;Investigation;Life;Longitudinal Studies;Longterm Follow-up;low socioeconomic status;marijuana use;maternal depression;maternal stress;Measures;Mental Health;Molecular;Molecular Profiling;Mothers;Natural Disasters;Natural experiment;neurobehavior;neurobehavioral;Neurocognitive;neurodevelopment;Neuropsychology;offspring;Outcome;pandemic disease;Parents;Pattern;Phase;Phenotype;Physiological;Pituitary Gland;Placenta;Population Heterogeneity;Positioning Attribute;postnatal;Predisposition;Pregnancy;Pregnant Women;prenatal;prenatal exposure;prenatal stress;Problem behavior;Progesterone;psychosocial;Psychosocial Stress;Puberty;public health relevance;Quasi-experiment;Race;recruit;repository;Research;Resources;response;Risk;Risk Marker;Risk Taking;Role;Sampling;Second Pregnancy Trimester;sex;Sex Differences;social;Social support;Socioeconomic Status;socioeconomics;Specimen;steroid hormone;Stress;stress reactivity;stressor;Structure of nail of toe;study population;Substance Use Disorder;Technology;Testing;Testosterone;Time;transcriptome sequencing;Wildfire;Woman;Work

PROJECT_TITLE: Epigenetic susceptibility of behavioral and addictive disorders during pre/pubescence after natural disaster exposures in-utero

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Liver Disease;Nutrition;Obesity

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Insulin resistance is commonly associated with obesity and is a major contributor to the development of obesity-related metabolic diseases, including nonalcoholic fatty liver disease, the metabolic syndrome, and insulin resistance and the metabolic syndrome. However, a subset of people with obesity are metabolically healthy (MHO) and protected from the adverse metabolic effects of excess adiposity. The mechanisms that determine the differences in metabolic health between people with MUO and MHO are not unclear. This project will examine the effects of plasma and adipose tissue small extracellular vesicles (sEVs) on multi-organ insulin action. We will isolate sEVs from subcutaneous abdominal adipose tissue biopsies and blood samples obtained from human participants with MHO, MUO or who are metabolically healthy and lean (MHL) and examine the effects of these sEVs on insulin resistance in muscle, liver and fat cells in culture and on insulin multi-organ insulin sensitivity in lean and obese mice. We will also identify differences in the potential bioactive molecules, namely miRNA and bioactive lipids, that are carried by sEVs. The results from this study will help determine whether plasma or adipose tissue sEVs in people who are MHL, MHO, or MUO are involved in regulating liver, muscle and adipose tissue insulin sensitivity. These results could identify novel pathways that regulate metabolic health in people and provide the foundation for exploring the potential of sEVs as a therapeutic target to prevent and treat the metabolic complications of obesity.

PI_NAMEs: KLEIN, SAMUEL  (contact);SAMOVSKI, DMITRI

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Abdomen;Address;Adipocytes;Adipose tissue;Adverse effects;Biopsy Specimen;Blood Circulation;Blood specimen;Body mass index;Body System;Body Weight decreased;Cells;Ceramides;design;Diglycerides;exosome;extracellular vesicles;Foundations;FOXO1A gene;Future;Gene Expression;Gene Proteins;glucose production;glucose tolerance;glucose uptake;Health;Hepatocyte;Heterogeneity;Human;Impairment;In Vitro;in vivo;insight;Insulin;insulin regulation;Insulin Resistance;insulin sensitivity;insulin signaling;IRS1 gene;Lipids;Lipolysis;liquid chromatography mass spectrometry;Liver;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;MicroRNAs;Modeling;Mus;Muscle;Muscle Cells;Muscle Fibers;new therapeutic target;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclease Protection Assays;Obese Mice;Obesity;obesity development;Organ;Participant;Pathway interactions;PDPK1 gene;Persons;Phosphorylation;Plasma;prevent;Proteins;Proteomics;subcutaneous;Technology;Therapeutic Intervention;therapeutic target;Thinness;transcriptome sequencing;vesicular release;Western Blotting

PROJECT_TITLE: Exosomes and insulin action in metabolically healthy and unhealthy obesity

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Hypertension;Nutrition;Physical Activity;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Eliminating racial/ethnic cardiovascular health disparities in the U.S. cannot be achieved without addressing disparities in evidence-based treatment of hypertension. In the Los Angeles County Department of Health Services (LAC DHS), the second largest municipal health system in the US, patient, clinician, healthy system, and community factors contribute to substantial disparities in hypertension prevalence, control, and outcomes by race/ethnicity. In this study, we use innovative methods in implementation science, community engagement, and behavioral economics to develop and deploy culturally-tailored, multi-level, sustainable implementation strategies that improve blood pressure control and reduce hypertension-related health disparities.

PI_NAMEs: BROWN, ARLEEN F. (contact);CASILLAS, ALEJANDRA

PROGRAM_OFFICER_NAME: MASTERSON, MARY YAA SEDEGAH

PROJECT_TERMS: Address;Adoption;Adult;African American;Anti-Hypertensive Agents;Asian;Asian Americans;Awareness;behavioral economics;blood pressure control;Cardiovascular Diseases;cardiovascular health;Caring;Cerebrovascular Disorders;Chronic Kidney Failure;Clinic;Clinical;Cluster randomized trial;Combined Modality Therapy;Communities;community engagement;Community Health Aides;community organizations;community-level factor;cost;cost effective;County;design;disease disparity;Disparity;disparity reduction;Dose;Education;Effectiveness;effectiveness evaluation;effectiveness testing;Electronic Health Record;ethnic health disparity;Ethnic Origin;Ethnic Population;evidence base;Evidence based practice;Evidence based treatment;Exercise;Exploration, Preparation, Implementation, and Sustainment;Exposure to;federal poverty level;Filipino;health disparity;Health Food;Health Services;Health system;Healthy Eating;healthy lifestyle;Heart Diseases;Heart failure;Household;Hypertension;hypertension control;hypertension treatment;implementation evaluation;implementation outcomes;implementation process;implementation science;implementation strategy;improved;Income;Individual;innovation;Intervention;Kidney Diseases;Latino;Leadership;Life Expectancy;Link;Los Angeles;medication compliance;Medication Management;Mediterranean Diet;Methods;Mission;Modification;mortality;multi-ethnic;Municipalities;Myocardial Ischemia;Obesity;Outcome;Patients;personal narratives;Pharmacists;Pharmacotherapy;Phase;Physical activity;Physicians;pill;population based;preference;Preparation;Prevalence;primary care clinic;primary care practice;Process;public-private partnership;Race;racial health disparity;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Resources;Schedule;Self Perception;Services;shared decision making;social;social norm;Subgroup;supported housing;System;Transportation;trial design;uptake;Visit

PROJECT_TITLE: Multi-ethnic Multi-level Strategies and Behavioral Economics to Eliminate Hypertension Disparities in LA County.


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences;Regenerative Medicine

ORG_CITY: Los Angeles

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: To date, no therapy exists to restore vision in the more than 64 million people worldwide who are legally blind as a result of diseases that damage the optic nerve, a nerve comprised of retinal ganglion cell (RGC) axons that relay visual information from the eye to the brain. The proposed research builds upon promising results by our group showing that electric fields direct regeneration of RGC axons in vitro and in vivo, even when applied after degeneration has started to set in. This project will lay the groundwork for the future development of a breakthrough electric field-based therapy to regenerate the optic nerve using novel waveforms and systems.

PI_NAMEs: GOKOFFSKI, KIMBERLY K (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Adult;Aftercare;Anatomy;Animals;Area;Automobile Driving;Axon;axon growth;axon injury;axon regeneration;Behavioral;Blinded;Brain;cell behavior;Cell Survival;Charge;Clinical;clinical application;Collection;combinatorial;comparative efficacy;Crush Injury;Data;Dependence;Development;diencephalon;Disease;Dorsal;electric field;Electric Stimulation;Electrical Engineering;Electrodes;Electron Microscopy;Electrophysiology (science);Electroretinography;experimental study;Eye;Functional disorder;Future;Growth;Growth Cones;Histologic;Hybrids;Immunohistochemistry;In Vitro;in vivo;Incidence;inhibitor;Interdisciplinary Study;interest;Investigation;Label;Lateral Geniculate Body;Legal Blindness;legally blind;Length;Light;Location;multimodality;Myelin;myelination;Natural regeneration;neoplastic;Nerve;Neurons;Neurosurgeon;novel;Optic Nerve;optic nerve disorder;optic nerve regeneration;Optic Nerve Transections;Optic tract structure;Patients;Pattern;Persons;Physiologic pulse;Potassium Channel Blockers;prophylactic;Rattus;Recovery;Recovery of Function;Regenerative response;remyelination;Reporting;Research;response;restoration;retinal ganglion cell regeneration;Retinal Ganglion Cells;Risk;sight restoration;Signal Pathway;Signal Transduction;Source;stem;superior colliculus Corpora quadrigemina;Synapses;Synaptic Transmission;System;Techniques;Technology;Testing;Tissues;Translations;transmission process;Viral;Vision;Visual;visual information;voltage;Work

PROJECT_TITLE: Restoration of Optic Nerve Function Driven by In Vivo Multimodal Electrical Stimulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Our overarching goal is to leverage the rich institutional environment at UCSF to develop a core curriculum to train a first generation of neurologists (primary learners: residents; other learners: medical students and clinical fellows) who are competent in providing sex and gender informed neurological care, and in understanding how to design and interpret studies informed by sex and gender. Deep exploration opportunities for interest learners include planning a mentored inquiry workshop, and participating in outpatient clinical selectives. A roadmap will be developed to support dissemination of the curriculum to other institutions and societies.

PI_NAMEs: BOVE, RILEY MARIE BROWNE (contact)

PROGRAM_OFFICER_NAME: HOMMER, REBECCA EVE

PROJECT_TERMS: Acceleration;Active Learning;Adult;Advisory Committees;Animals;Area;Basic Science;Benchmarking;Caring;Clinical;Clinical Competence;clinical practice;Clinical Research;Clinical Trials;clinically relevant;Collaborations;Committee Members;Communities;Competence;Complementary Health;curriculum development;design;Development;Discipline of obstetrics;diversity and equity;Education;Education Projects;education research;Educational Curriculum;Educational Materials;Educational Models;Educational workshop;Environment;Evaluation;evidence base;experience;Faculty;faculty mentor;Feedback;Foundations;Friends;Funding;Gender;Generations;Goals;Growth;Health;health care delivery;Hormonal;Human;innovation;Institution;interest;Journals;Knowledge;Lead;Learning;learning materials;lectures;lens;Life Cycle Stages;life span;Literature;Medical Students;Mentors;Motivation;Neonatology;Nerve Degeneration;Nervous System Disorder;neurodevelopment;Neurologic;Neurologist;Neurology;Neurosciences;Neurosciences Research;next generation;novel;Outcome;Outpatients;Paper;Participant;Patients;programs;Publications;Questionnaires;reproductive;Research;Residencies;response;Risk;Role;satisfaction;Scientist;Self Efficacy;sex;skills;Societies;Students;success;Surveys;tool;Training;Training Activity;Translational Research;translational study;Translations;Women's Health

PROJECT_TITLE: Sex and Gender Enriched Neurology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-K(50)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;HIV/AIDS;Hematology;Hodgkin's Disease;Infectious Diseases;Lymphatic Research;Lymphoma;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PUBLIC HEALTH RELEVANCE Epstein-Barr virus (EBV) is an important cause of human lymphomas such as Burkitt lymphomas (BLs) and diffuse large B cell lymphomas (DLBCLs) that have stringent forms of viral latency (types I and II) that cannot transform B cells in vitro. We have recently developed a new model system that allows us to obtain EBV-infected BL-like lymphomas with type I latency and EBV-infected DLBCLs with type II latency in naïve B cells. In this proposal, we will extend this model into primary human GC B cells, define the specific EBV genes and/or RNAs required to form each tumor type, and identify pathways that restore expression of the EBV LMP1 protein in BL- like tumors, thereby enhancing the T cell response to BL-like tumors in humanized mice.

PI_NAMEs: KENNEY, SHANNON CELESTE (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: anti-tumor immune response;B-Cell Lymphomas;B-Cell Neoplasm;B-Lymphocytes;Biological Models;Burkitt Lymphoma;Cell Culture Techniques;Cell Line;Cells;Development;DNA Methylation;DNA Methylation Inhibition;DNMT3B gene;EBNA2 protein;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Epstein-Barr Virus-Related Lymphoma;experimental study;Gene Mutation;Genes;Genetic Transcription;Growth;HIV Infections;Hodgkin Disease;Human;Human Herpesvirus 4;humanized mouse;Immune response;Immunocompetent;Immunocompromised Host;immunogenic;immunosuppressed;In Vitro;in vitro Model;in vivo;in vivo Model;infected B cell;interleukin-21;large cell Diffuse non-Hodgkin's lymphoma;LMP1;Lymphoma;Mediating;Modeling;mouse model;Mus;mutant;MYC gene;neoplastic cell;novel;Oncogenic Viruses;overexpression;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;promoter;Proteins;public health relevance;restoration;Retroviral Vector;Retroviridae;RNA;Role;small molecule;stable cell line;Structure of germinal center of lymph node;System;T cell response;T-Lymphocyte;Testing;Time;TNFSF5 gene;Tonsil;transcription factor;transforming virus;tumor;Umbilical Cord Blood;Viral;Viral Proteins;viral RNA;Virus Latency

PROJECT_TITLE: Roles of LMP1 and MYC in EBV-induced B-cell tumors


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Bipolar Disorder;Brain Disorders;Data Science;Depression;Genetics;Human Genome;Major Depressive Disorder;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Schizophrenia;Serious Mental Illness

PHR: NARRATIVE White matter circuitry is the basis for neuronal communication in the human brain and has been found to be abnormal in all major psychiatric, neurological, and developmental conditions. Our proposed work significantly extends the worldwide ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) consortium by mapping novel white matter circuitry biomarkers and the variability that drives underlying risk for mental illness. We will coordinate global genome-wide investigations into the genomic architecture of white matter structural and microstructural metrics in over 100,000 individuals of all ages in a discovery/replication framework and further, construct and disseminate an integrated ENIGMA DSI Studio pipeline offering coordinated, high- throughput, tractography and fiber analytic methods to identify structural dysconnectivity in ENIGMA working groups on severe mental illnesses.

PI_NAMEs: JAHANSHAD, NEDA  (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Age;analytical method;Architecture;Area;Automation;Behavior;Big Data to Knowledge;Bioinformatics;Biological Markers;biomarker identification;Bipolar Disorder;Brain;Brain imaging;Brain Mapping;Clinical;cohort;Collaborations;Communication;Communities;Complex;Computer software;Corpus Callosum;Data;Data Analyses;data integration;Data Science;Data Set;Development;Diagnosis;Diagnostic;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;distributed data;empowerment;Ensure;Exhibits;Fiber;follow-up;Genetic;genetic architecture;Genetic Risk;Genetic Variation;genome wide association study;genome-wide;genomic locus;Genomics;Guidelines;Human;Image;imaging biomarker;imaging modality;Individual;innovation;interest;International;Investigation;Language;life span;Link;Magnetic Resonance Imaging;Major Depressive Disorder;Maps;Measures;Mental disorders;Mental Health;Meta-Analysis;Metadata;Methods;Motion;multidisciplinary;Neurobiology;neuroimaging;Neurologic;Neurons;neuropsychiatry;novel;Ontology;Pattern;pleiotropism;Population;power analysis;Productivity;Protocols documentation;Proxy;Psychiatry;psychogenetics;Psychoses;Quality Control;rare variant;Reproducibility;Research;Research Personnel;Risk;Scanning;Schizophrenia;Sensitivity and Specificity;severe mental illness;sex;Shapes;Structural defect;Structure;suicidal behavior;Symptoms;Thick;Time;tool;tractography;Training;Treatment outcome;United States National Institutes of Health;Update;user-friendly;Variant;Ventricular;white matter;Work;working group

PROJECT_TITLE: Global studies into the Genetic Architecture of the Brain's White Matter Network through Harmonized and Coordinated Analyses in the ENIGMA-Consortium

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Transplantation

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE The gene APOL1 has been associated with increased risk of chronic kidney disease in African Americans. North East Consortium for Transplant Outcomes in APOL1 Kidney Recipients (NECTAR) Clinical Center, APOLLO CC6, will study the impact of this gene on long-term outcomes in renal transplant recipients that receive a kidney from an AA donor and on renal function of AA living donors by leveraging the infrastructure and collaborations established in Phase 1. In Phase 2, we will maximize long-term clinical data capture, recruitment of AA living donors and biospecimen collection according to the goals of the Consortium.

PI_NAMEs: DADHANIA, DARSHANA  (contact);FAROUK, SAMIRA

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Academic Medical Centers;Acceleration;Acute;Address;African American;African American population;African ancestry;Albumins;Allografting;American;Antibodies;APOL1 gene;Apolipoproteins;Bacterial Infections;biomarker identification;Biopsy;Blood;Chronic Kidney Failure;Clinical;clinical center;Clinical Data;cohort;Collaborations;Collection;Communication;Consent;Cost Savings;Counseling;Creatinine;Data;Databases;Diagnostic;digital pathology;Disparity;DNA;Education;End stage renal failure;Enrollment;Ensure;Environmental Risk Factor;ethnic difference;Evaluation;Exhibits;Failure;follow-up;gene interaction;Genes;Genetic;genetic risk factor;Genotype;Goals;graft failure;Graft Survival;Health;Health Care Costs;Health protection;high risk;Histocompatibility;HLA Antigens;Immunogenetics;Immunosuppression;improved;Individual;Infrastructure;interest;Kidney;kidney biopsy;Kidney Failure;Kidney Transplantation;Lesion;Living Donors;Longterm Follow-up;Measurement;Measures;Medical;Medical center;medical schools;member;Monitor;New York;non-diabetic;novel;Organ;Organ Procurements;Outcome;Outcome Study;Participant;participant enrollment;Pattern;Phase;Phenotype;Policies;post-transplant;predictive marker;Presbyterian Church;Prevalence;primary outcome;privacy protection;programs;prospective;Proteinuria;Protocols documentation;Quality of life;racial difference;recruit;Recurrent disease;Registries;Renal function;Reporting;repository;Research;response;Risk;risk variant;Role;Safety;secondary outcome;Serum;Site;Slide;Societies;Time;transplant centers;Transplant Recipients;transplant registry;Transplantation;United Network for Organ Sharing;United States National Institutes of Health;Universities;University Hospitals;Urine;Variant;Virus Diseases;Wood material

PROJECT_TITLE: 6/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center


ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE CC11 APOLLO Clinical Center Network comprises of all major active kidney transplant centers in Florida and Puerto Rico, as well as the University of California-Irvine and California Institute of Renal Research. To support the APOLLO Consortium’s goal of enrolling all kidney transplant recipients across the United States who received a kidney from an African American donor, as well as all African American living donors, we will continue to leverage the infrastructure and collaboration we built in Phase 1 to ensure that we continue to obtain complete clinical data, urine albumin-to-creatinine ratio, and facilitate return of genetic test results to fulfill the mission of Phase 2. Additionally, we will also continue to enroll living kidney donors and obtain biospecimens for participants enrolled in Phase 1 at the Miami Transplant Institute, Jackson Memorial Hospital, according to the goals of the Consortium.

PI_NAMEs: FORNONI, ALESSIA  (contact);ORTIGOSA-GOGGINS, MARIELLA CECILIA

PROJECT_TERMS: Acceleration;Acute;Address;African American;African ancestry;Albumins;Allografting;American;Antibodies;APOL1 gene;Apolipoproteins;Bacterial Infections;biobank;Biology;Biopsy;Blood;California;Clinic;clinical center;Clinical Data;cohort;Collaborations;Collection;Computerized Medical Record;Consent;Cost Savings;Counseling;Creatinine;Data;Databases;digital pathology;Disparity;DNA;Donor person;Education;Eligibility Determination;Enrollment;Ensure;Environmental Risk Factor;ethnic difference;European;Evaluation;Face;Failure;Florida;follow-up;gene interaction;Gene Mutation;General Hospitals;Genes;genetic risk factor;genetic testing;Genotype;Geography;Goals;graft failure;graft function;Graft Survival;Hand;Health;Health Care Costs;Healthcare Systems;high risk;HLA Antigens;Hospitals;Immunosuppression;improved;Individual;Infrastructure;Kidney;kidney biopsy;Kidney Failure;Kidney Transplantation;Lesion;Living Donors;living kidney donor;Longterm Follow-up;Measures;Medical;member;Mission;novel;Observational Study;Organ;Organ Procurements;Outcome;Participant;participant enrollment;Patients;Pattern;Phase;Policies;post-transplant;Prevalence;primary outcome;programs;prospective;Proteinuria;Puerto Rico;racial difference;recruit;Recurrent disease;Registries;Renal function;Reporting;repository;Research;response;Risk;Risk Factors;risk variant;Role;Safety;secondary outcome;Serum;Site;Slide;Test Result;Time;transplant centers;Transplant Recipients;transplant registry;Transplantation;United Network for Organ Sharing;United States;United States National Institutes of Health;Universities;Urine;Variant;Virus Diseases;Work

PROJECT_TITLE: 1-13 ApoL1 Genotypes in Kidney Donors and Long-Term Outcomes in Kidney Transplant Recipients Clinical Center


ADMINISTERING_IC: AI

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SEATTLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Over 20 million people living with HIV (PLHIV) are receiving antiretroviral therapy and require HIV viral load testing to identify cases of virological failure and provide actionable information to guide alternative clinical treatment. Current methods for HIV viral load measurement rely on quantitative PCR (qPCR) or digital PCR (dPCR), which are commonly restricted to highly resourced central laboratories and there is a need to decentralize HIV viral load monitoring to enable rapid, clinic-based or home self-testing viral load measurements. Here we develop a rapid POC HIV viral load test using digital isothermal amplification that leverages the characteristic viscous reaction buffer of recombinase polymerase amplification (RPA) isothermal amplification chemistry and commercially available porous membranes to accurately quantify HIV-1 RNA over clinically relevant HIV-1 subtypes and viral loads.

PI_NAMEs: POSNER, JONATHAN D (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Address;Adherence;antiretroviral therapy;base;Biological Assay;Buffers;Characteristics;Chemistry;Clinic;Clinical Treatment;clinically relevant;Complex;cost;Data;Decentralization;detection limit;Diagnostic;diagnostic platform;diagnostic tool;digital;DNA;Emulsions;Event;Failure;Genomics;Health;Heating;Heterogeneity;HIV;HIV drug resistance;HIV Infections;HIV-1;Home;Image Analysis;improved;Incubated;Individual;instrument;isothermal amplification;Kinetics;Laboratories;Machine Learning;Measures;Membrane;Methods;Microfluidic Microchips;Molecular;Monitor;novel;Nucleic Acid Amplification Tests;Nucleic Acids;Outcome;Paper;Patients;Persons;Plasma;point-of-care diagnostics;Poisson Distribution;Polymerase;Porosity;Procedures;Property;Public Health;Reaction;recombinase;Resources;response;Risk;RNA;Running;Scheme;self testing;Site;statistics;Temperature;Testing;Time;transmission process;Viral;Viral load measurement;Viral Load result;viral RNA;Viscosity

PROJECT_TITLE: Rapid, quantitative isothermal molecular assay for POC HIV-1 viral load monitoring using amplification nucleation site analysis

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative: DNA methylation is a critical epigenetic modification that is required for proper neuronal development, and improper DNA methylation is associated with autism-associated neurodevelopmental disease; but it is fundamentally unknown how the DNA methylation landscape is faithfully established across the neuronal genome. The proposed research will utilize genomic approaches to examine how the histone modification H3K36me2 functions to guide DNA methyltransferase 3A (DNMT3A) to establish the neuronal DNA methylation landscape and investigate how disruption of H3K36 methylation-mediated interactions with DNMT3A disturbs critical patterns of DNA methylation to disrupt neuronal transcription and brain function. Completing these goals will elucidate novel paradigms of H3K36 methylation function in the developing brain and provide insight into how mutations in H3K36 methyltransferases may lead to neurodevelopmental disorders.

PI_NAMEs: HAMAGAMI-SAMSON, NICOLE  (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Adult;Affect;Affinity;ASH1L gene;autism spectrum disorder;Binding;Brain;brain dysfunction;career;Child;Chromatin;chromatin modification;Clinical;conditional knockout;Deposition;Development;Dinucleoside Phosphates;Disease;DNA Methylation;DNA Modification Methylases;DNA Modification Process;Enhancers;Enzymes;Epigenetic Process;epigenomics;Functional disorder;Gene Expression;gene regulatory network;Genes;Genetic;Genetic study;Genetic Transcription;Genome;genome-wide;genome-wide analysis;Genomic approach;genomic data;Genomics;Goals;histone methyltransferase;histone modification;Histones;Human Genetics;Impairment;In Vitro;in vivo;insight;knock-down;Knockout Mice;Knowledge;Laboratories;Link;Mammalian Cell;Measures;Mediating;Methods;Methyl-CpG-Binding Protein 2;Methylation;methylation pattern;Methyltransferase;Modeling;Modification;Molecular;Mutant Strains Mice;Mutate;Mutation;Nervous System;neurodevelopment;Neurodevelopmental Disorder;Neuroglia;Neurologist;neuron development;Neurons;novel;Outcome;Pathology;Pathway interactions;Pattern;Play;Process;programs;Publishing;PWWP Domain;Reading;recruit;Regulation;Research;Research Training;Role;Site;Syndrome;System;Testing;Training;Transcriptional Regulation;transcriptome sequencing;Up-Regulation;Wild Type Mouse;Work;Writing

PROJECT_TITLE: The role of H3K36 methyltransferases on non-CpG methylation patterning in the mammalian brain


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision

ORG_CITY: GOLDEN

ORG_NAME: COLORADO SCHOOL OF MINES

ORG_STATE: CO

PHR: Currently most treatments for back of the eye diseases are based on frequent intravitreal injections, which are invasive, and could lead to serious complications such as endophthalmitis and retinal detachment. Here we propose to use novel engineered contact lenses to nonivasively deliver drugs capable of treating diabetic macular edema and posterior uveitis to the back of the eye. We have preliminary data showing feasibility of contact lens mediated delivery of drugs to the back of the eye and in this proposal, we focus on establishing the mechanisms and designing and testing novel contact lenses for delivery of small molecules and biologics to the back of the eye.

PI_NAMEs: CHAUHAN, ANUJ  (contact);KOMPELLA, UDAY B

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Adrenal Cortex Hormones;Age related macular degeneration;Animal Model;Anterior;anterior chamber;Antibodies;Area;Attention;Back;bevacizumab;Biocompatible Materials;Biological;Biological Availability;Biological Products;bulbar conjunctiva;Choroid;Clinical;conjunctiva;Contact Lenses;Convection;Cornea;Data;design;Devices;Dexamethasone;diabetic;Diameter;Diffuse;Diffusion;Disease;Drops;Drug Controls;Drug Delivery Systems;Drug Design;Drug Exposure;Drug Kinetics;drug release kinetics;Drug Transport;Endophthalmitis;Engineering;experience;experimental study;Eye;Eye diseases;Eyedrops;Formulation;Frequencies;Hour;Hydrogels;Hydrophilic Contact Lenses;Hydrophobicity;in silico;In Vitro;in vivo;in vivo monitoring;Injections;insight;intravitreal injection;Lateral;Length;lens;lipophilicity;macular edema;manufacture;mathematical model;Measures;Mediating;Modeling;New Zealand;novel;novel strategies;Ocular Physiology;ophthalmic drug;Oryctolagus cuniculus;Pathway interactions;Pharmaceutical Preparations;Pharmacology;Pilocarpine;polymerization;Polymers;Porosity;Posterior eyeball segment structure;Posterior Uveitis;Prazosin;predictive modeling;pressure;Property;Recommendation;Research;Research Personnel;residence;Retina;Retinal Detachment;Retinal Diseases;Role;Rotation;Scheme;Sclera;Series;Side;Silicones;small molecule;Steroids;Testing;Therapeutic;Time;Tissues;tool;Topical application;Treatment outcome;Vitamin E

PROJECT_TITLE: Back of the eye drug delivery: Novel contact lenses, pathways, and in-silico modeling

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


NIH_SPENDING_CATS: Behavioral and Social Science;Nutrition;Obesity;Prevention

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: The regulation of body weight - and the impact of excess weight on clinical phenotypes such as diabetes, cardiovascular disease and cancer - is extremely complex necessitating special training in centers with broad basic and translational research portfolios for the scientists who will help to break this nexus of disease. This K26 is to support mentoring of early career investigators from underrepresented and diverse backgrounds through providing protected effort and resources to Dr. Gallagher who will deliver focused mentoring, academic course work, sophisticated research experiences, and career development and networking, enabling them to transition to research independence. This program has important national implications by virtue of adding to a critical group of diverse bioscientists.

PI_NAMEs: GALLAGHER, DYMPNA  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Academia;Adipose tissue;adult obesity;Advisory Committees;Advocate;Age;Award;Awareness;Basic Science;Behavior;Behavior assessment;Behavioral;Biological;Biology;Body Composition;Body Weight;Body Weight Changes;Body Weight decreased;Calendar;Cardiovascular Diseases;career;career development;Career Mobility;career networking;Chronic Disease;Clinical;clinical development;Clinical Investigator;clinical phenotype;Clinical Research;Collaborations;Complex;cultural competence;Cultural Diversity;Data Reporting;design;Development;Diabetes Mellitus;Discipline;Disease;Educational process of instructing;Energy Intake;Energy Metabolism;Ensure;Environment;Event;evidence base;Exercise;experience;Experimental Designs;Exposure to;Faculty;follow-up;Food;Funding;General Population;graduate student;Grant;Health;Health Care Costs;Heterogeneity;Homeostasis;Human;Human body;human subject;Hunger;Individual;Intervention;Knowledge;Leadership;leadership development;Learning;Maintenance;Malignant Neoplasms;Manuscripts;Measurement;Measures;meetings;Mentors;Mentorship;Metabolic;Methodology;Methods;Molecular;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;New York;nutrition;Nutritional;Obesity;Outcome;Paper;Participant;participant enrollment;Pathway interactions;Persons;Phase;Phenotype;Physical activity;Physiological;Physiology;Positioning Attribute;Postdoctoral Fellow;Preparation;Procedures;Productivity;programs;prospective;psychologic;psychosocial;Psychosocial Assessment and Care;recidivism;Regulation;Reproducibility;Research;research and development;Research Personnel;research study;Resources;response;Rest;Role;Scientist;Services;Severities;sex;skills;sleep quality;Societies;success;System;Thinness;Time;Tissue Sample;total energy expenditure;Training;Training Programs;Translational Research;Travel;Underrepresented Populations;United States;Vocational Guidance;Weight;Work;Writing

PROJECT_TITLE: Support Mentoring of Early Career Clinical Researchers from Diverse Backgrounds


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Opioids;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The Mu and Kappa Opioid Receptor (MOR, KOR) systems are implicated in craving and mood, and thus important for the understanding of addiction. The MOR and KOR systems have never been probed in a single cohort of patients suffering from Alcohol Use Disorder. We will use PET imaging and various analyses, including kinetic modeling and machine learning, to explore the relationships between MOR and KOR status and patients' behaviors during a monitored attempt to abstain from drinking.

PI_NAMEs: COSGROVE, KELLY P.;MORRIS, EVAN D (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Abstinence;addiction;Adult;Age;alcohol abuse therapy;alcohol behavior;Alcohol consumption;alcohol craving;alcohol measurement;alcohol use disorder;Alcohols;Amygdaloid structure;Anhedonia;Animals;Behavior;Binding;biomarker identification;Brain imaging;carfentanil;Classification;Classification Scheme;Clinical;clinically relevant;cohort;contingency management;Corpus striatum structure;craving;cue reactivity;Data;Data Set;demographics;Development;Diagnosis;Down-Regulation;drinking;Drug Combinations;Drug Metabolic Detoxication;Drug Targeting;DSM-V;dysphoria;Equilibrium;Euphoria;Future;Globus Pallidus;Goals;Human;Image;imaging biomarker;improved;Individual;individual patient;individualized medicine;Inpatients;Joints;kappa opioid receptors;kappa receptors;kinetic model;Knowledge;Linear Models;Literature;Machine Learning;Measures;Medical;Monitor;Moods;mu opioid receptors;mu receptors;Naltrexone;Neurobiology;neuroimaging;new therapeutic target;novel;Opioid;Opioid Antagonist;Opioid Receptor;Outcome;Outpatients;Participant;Patients;Persons;Pharmacotherapy;Play;Positron-Emission Tomography;pre-clinical;predict clinical outcome;Protocols documentation;receptor;Recovery;recruit;regional difference;Relapse;response;Role;Scanning;sex;System;Techniques;Testing;Time;Tracer;Up-Regulation;Ventral Striatum;Withdrawal

PROJECT_TITLE: Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use Disorder


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: 8. Project Narrative The psychosocial environment is known to be associated with the unfolding of child health outcomes beginning very early in development, yet questions remain about the specific mechanisms linking psychosocial exposures and child health outcomes, and the calibration of the timing linking an exposure with an outcome. The proposed study adds to and extends the ECHO program by conducting annual assessments of our current ECHO cohort children thru age 20. When combined with other ECHO cohort data, this study will enable an in depth look at how adolescence can be a pivotal period in development for studying the timing of the effects of early psychosocial exposures and testing outcome-specific models that determine whether early psychosocial exposures have longer-term effects, latent or delayed effects, and/or desisting effects.

PI_NAMEs: GANIBAN, JODY M.;LEVE, LESLIE DIANE (contact);NEIDERHISER, JENAE M.

PROGRAM_OFFICER_NAME: ZANETTI, KRISTA A

PROJECT_TERMS: 20 year old;Address;Adherence;Adolescence;Adolescent;Affect;Age;aged;anxiety symptoms;Area;Attention deficit hyperactivity disorder;Award;Biological;Biology;Birth;Brain;Calibration;Characteristics;Child;Child Development;Child Health;Child Mental Health;Child Rearing;Child Support;Childbirth;Childhood;Classification;cohort;Cohort Studies;Conceptions;Conduct Disorder;Data;Data Element;data sharing;depressive symptoms;design;Development;Dimensions;Discrimination;Economics;Emotional;Enrollment;Ensure;Environment;Environmental Exposure;Esthesia;Ethnic Origin;Ethnic Population;Family;follow-up;Follow-Up Studies;Funding;Generations;Geography;Goals;Growth;Growth and Development function;Health;improved;Individual;Individual Differences;infancy;Infrastructure;insight;Intervention;Interviewer;Investigation;Knowledge;Lead;life span;Link;Longitudinal Studies;Low income;Manuscripts;Mental Health;Methods;middle childhood;Minority;Modeling;Neighborhoods;neurodevelopment;Neurodevelopmental Problem;novel;Outcome;Outcome Measure;Parents;Participant;Pediatric cohort;peer;Phase;phase 2 study;Policies;Population Heterogeneity;Predisposition;Pregnancy;prenatal;Process;Productivity;programs;protective factors;Protocols documentation;Psychologist;psychosocial;Puberty;racial identity;racial population;recruit;Research Design;Research Infrastructure;Research Personnel;resilience;retention rate;Risk;Risk Factors;Role;rural area;Sampling;Science;Shapes;Siblings;Site;social;Societies;Standardization;success;System;Temperament;Testing;Time;Training;urban area;Work

PROJECT_TITLE: The Early Growth and Development Study Cohort of the ECHO Program


PHR: PROJECT NARRATIVE  The proposed research is relevant to public health because the results are expected to provide much- needed evidence on which to base decisions regarding donating and accepting kidneys for transplantation. The absolute and relative risks of accepting a kidney from a donor with high-risk variants of APOL1 are needed to allow a potential recipient to make a fully informed decision on whether to accept a donated organ and the risks associated with high-risk APOL1 variants for a living kidney donor are also necessary to make this important decision. Clinicians caring for transplant recipients and donors will use these findings to personalize monitoring and interventions.

PI_NAMEs: ASTOR, BRAD C (contact)

PROJECT_TERMS: Academic Medical Centers;Acceleration;Acute;Address;African American;African ancestry;Albumins;Allografting;American;Antibodies;Apolipoproteins;Bacterial Infections;base;Blood;Caring;Clinic;clinical center;Clinical Data;cohort;Consent;Cost Savings;Counseling;Creatinine;Data;Disparity;DNA;Donor person;Education;Enrollment;Ensure;Environmental Risk Factor;ethnic difference;European;Evaluation;Face;Failure;follow-up;gene interaction;Genes;Genetic;genetic risk factor;genetic variant;Genotype;Geography;graft failure;graft function;Graft Survival;high risk;HLA Antigens;Immunosuppression;improved;Individual;Injury;Intervention;Iowa;Kidney;kidney biopsy;Kidney Failure;Kidney Transplantation;Lesion;Living Donors;living kidney donor;Longterm Follow-up;Measures;Medical;Minnesota;Monitor;Nebraska;novel;Organ;Outcome;Outcome Study;Participant;Pattern;Phase;Phenotype;Policies;post-transplant;Prevalence;primary outcome;programs;prospective;Proteinuria;Public Health;Quality of life;racial difference;recruit;Recurrent disease;Registries;Relative Risks;Renal function;Reporting;Research;Risk;risk variant;Role;Safety;secondary outcome;Serum;Time;Transplant Recipients;Transplantation;United Network for Organ Sharing;United States National Institutes of Health;Universities;Urine;Variant;Virus Diseases;Wisconsin

PROJECT_TITLE: 1/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Endocrine Disruptors;Nutrition;Pediatric;Prevention;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Early-life exposure to per- and polyfluorinated alkyl substances has been linked to a number of adverse health effects; however, PFAS toxicity and exposure assessment studies largely focus on a small number of PFAS. This proposal will evaluate aggregate exposure to PFAS mixtures using untargeted, unbiased methodology in maternal serum, placenta, cord blood, infant serum, formula, and breastmilk. The information collected in this study can be used to guide selection of PFAS for future studies and to inform guidance on breastfeeding in PFAS exposed populations.

PI_NAMEs: MANZ, KATHERINE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Active Learning;Address;Analytical Chemistry;analytical method;Behavior;Biological;Biological Monitoring;Biometry;Blood specimen;Body Burden;Breast Feeding;candidate selection;career;career development;Chemical Exposure;Chemicals;Child Health;Childhood;cohort;Communication;computerized data processing;Consumption;critical period;Data;Data Analyses;Developed Countries;Development;early life exposure;Environment;Environmental Engineering technology;Epidemiology;experience;exposed human population;Exposure to;Fluorine;Food;Funding;Future;Goals;Grant;Guidelines;Half-Life;Health;Human;Human Milk;Hypothyroidism;Individual;infancy;Infant;Infant formula;innovation;K-Series Research Career Programs;Knowledge;Leadership;Length;Life;Link;Low Birth Weight Infant;manufacture;maternal serum;Measures;member;Mentored Research Scientist Development Award;Mentors;Metabolic;Methodology;Methods;Milk;Mothers;next generation;Outcome;Outcome Study;perfluorooctane sulfonate;perfluorooctanoic acid;Perinatal;Phase;Placenta;placental transfer;Poly-fluoroalkyl substances;Population;post pregnancy;postnatal;Pre-Eclampsia;Predisposition;Pregnancy;prevent;Process Assessment;Production;Productivity;programs;Property;Public Health;Research;Research Design;Research Personnel;Rhode Island;Risk Assessment;Sampling;Serum;skill acquisition;skills;Source;Statistical Data Interpretation;statistics;Structure;substance use;symposium;Techniques;Testing;thyroid disruption;Time;Toxic effect;Toxicity Tests;Training;Umbilical Cord Blood;vaccine response;Vulnerable Populations

PROJECT_TITLE: Assessment of Early Life PFAS Exposure in Perinatal Biospecimens, Infant Formula, and Breastmilk.


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Macrophages are part of body’s immune system that play both a disease-fighting and an immune-suppressing role in cancer. We propose to develop a pair of PET imaging toolkits that are highly specific for human and mouse macrophages. This pair will allow us to study the role of macrophages in both clinical and preclinical applications.

PI_NAMEs: MARQUEZ-NOSTRA, BERNADETTE  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Address;Affinity;Aftercare;Binding;Biological;Biological Assay;Body part;Cancer Model;Cardiovascular Diseases;Cd68;Cell Separation;Cells;clinical application;clinical biomarkers;Clinical Research;clinical translation;co-clinical trial;companion animal;cross reactivity;CSF1R gene;Cytoplasm;cytotoxic;Data;density;Development;Disease;disease model;Drug Kinetics;fighting;Goals;Half-Life;Human;human imaging;human subject;Image;imaging probe;Immune;Immune checkpoint inhibitor;Immune system;immunogenicity;In Vitro;in vivo;Infiltration;Label;Lead;Libraries;Macrophage;Malignant Neoplasms;matrigel;Modeling;Monitor;mouse model;Mus;Neurodegenerative Disorders;novel;novel therapeutics;Orthologous Gene;pathogen;patient derived xenograft model;Peripheral Blood Mononuclear Cell;Phage Display;Play;Positron-Emission Tomography;pre-clinical;preclinical study;Prognosis;Property;Protein Glycosylation;Proteins;Radiolabeled;radioligand;radiotracer;Role;Sampling;screening;Specificity;Stains;Structure;Surface;Techniques;Testing;Tissues;trafficking;Translating;treatment effect;treatment response;tumor;tumor microenvironment;Tumor-associated macrophages;Work

PROJECT_TITLE: Development of novel human Fab probes for PET imaging of macrophages

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Orphan Drug;Pain Research;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: NARRATIVE We are leveraging cutting edge technologies in CRISPR/Cas9-mediated genome editing to treat sickle cell disease (SCD), a painful, life-threatening genetic disorder that affects 100,000 Americans and millions worldwide. Specifically, we will modify the blood forming cells of affected individuals to recreate a naturally occurring genetic condition that eliminates the deleterious effects of SCD. Our work has the potential to relieve suffering and extend the lifespan of patients with severe SCD.

PI_NAMEs: SHARMA, AKSHAY ;TSAI, SHENGDAR ;WEISS, MITCHELL J (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Acute Pain;Adult;Affect;Allogenic;AMD3100;American;analytical method;Attention;Autologous;BCL11A gene;bench to bedside;beta Globin;Binding;Bioethics Consultants;Biological Assay;Biological Markers;biophysical properties;Birth;Blood;Bone Marrow;Caring;CD34 gene;Cell Differentiation process;Cells;Cessation of life;Chromosomal Rearrangement;chronic pain;Clinical;clinical practice;Clinical Research;Clinical Trials;Communities;Complex;CRISPR/Cas technology;curative treatments;Data;debilitating pain;design;Deterioration;Development;Disease;early phase clinical trial;Education;efficacy evaluation;Engineering;Engraftment;Enhancers;Erythrocytes;Erythroid;erythroid differentiation;Erythropoiesis;Euthanasia;Exhibits;experience;extend lifespan;feasibility testing;Fetal Hemoglobin;first-in-human;Functional disorder;Future;Gene Modified;gene therapy;Genes;Genetic;Genetic Diseases;Genetic Transcription;genetic variant;genome editing;genome-wide;genotoxicity;Globin;Good Manufacturing Process;Guide RNA;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemoglobin;Human;Immune;Immunodeficient Mouse;Impairment;improved;In Vitro;in vivo;indexing;Individual;Informed Consent;Infusion procedures;insertion/deletion mutation;Laboratory Scientists;Lead;Life;manufacture;manufacturing process;Mediating;Medical;Missense Mutation;Modification;Molecular;Monitor;multidisciplinary;Multiple Organ Failure;Mus;Mutation Detection;Normal Cell;novel;novel therapeutics;Nuclear Localization Signal;off-target mutation;Organ;Outcome;Pain;Parents;Participant;patient oriented;Patients;Perinatal;Pharmaceutical Preparations;Pharmacology Study;polymerization;Polymers;pre-clinical;premature;Premature Mortality;Process;Process Assessment;process optimization;Production;promoter;Protocols documentation;Publishing;Quality Control;Quality of life;Repressor Proteins;Research;research study;Ribonucleoproteins;Running;Safety;safety assessment;Saint Jude Children's Research Hospital;scale up;Sickle Cell Anemia;Sickle Cell Trait;Sickle Hemoglobin;sickling;Specific qualifier value;stem cell growth;stem cell therapy;Stem cell transplant;stem cells;Technology;Testing;Therapeutic;therapeutic genome editing;Toxic effect;Toxicology;Transcription Repressor;Transfection;Translating;Variant;Work;Xenograft procedure

PROJECT_TITLE: Novel therapeutic gene editing to induce fetal hemoglobin for sickle cell disease

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: The Neural Code and Dynamics of the Reading Network We direct these will afflicts function also  will identify t he specific roles and interactional properties of brain areas involved in reading by obtaining  ecordings from the human brain f rom patients with electrodes placed to localize epilepsy, and we will use  data and analyses to understand how we read fluently and how we learn to read new words. This work (1) provide insights into normal reading in humans, ( 2) greatly enhance our understanding of dyslexia that millions of children and adults, and (3) enable us to prevent i nadvertent injury that may impair this vital in patients undergoing neurosurgical operations. Someday, based on the knowledge gained, we may be able to design prosthetic devices that could help patients with profound dyslexia. r

PI_NAMEs: TANDON, NITIN  (contact)

PROGRAM_OFFICER_NAME: GEBREHIWET, HERMON RUSSOM


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Digestive Diseases;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Inflammatory Bowel Disease;Racial and Ethnic Minority Health Research

ORG_CITY: MONTREAL

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: MONTREAL HEART INSTITUTE

ORG_STATE: PQ

ORG_ZIPCODE: H1T 1C8

PHR: PROJECT NARRATIVE This project aims to identify the genetic causes of the inflammatory bowel diseases (IBD) known as Crohn's Disease (CD) and ulcerative colitis (UC), particularly in populations currently underrepresented in IBD genetic studies. We further aim to determine biological impact of the genetic risk factors to better understand disease processes. Finally we aim to identify blood based markers associated with good vs poor treatment responses.

PI_NAMEs: RIOUX, JOHN D. (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Admixture;African American;African American population;American;antimicrobial;Apical;Behavior;Binding;Biological;Biological Assay;Biological Markers;Blood;Blood specimen;blood-based biomarker;Boston;causal variant;CCL11 gene;Cell model;Cells;Chronic;Clinical assessments;clinical heterogeneity;clinical remission;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;Collaborations;Complex;Crohn's disease;Data;Data Collection;design;Development;Disease;disease phenotype;endoplasmic reticulum stress;Ensure;Epithelial Cells;Epithelium;Etiology;exome sequencing;experimental study;fecal microbiome;Gastrointestinal tract structure;Gene Frequency;General Hospitals;Genes;Genetic;genetic architecture;Genetic Diseases;Genetic Engineering;Genetic Research;genetic risk factor;Genetic study;Genetic Variation;genome sequencing;genome wide association study;Genomics;Hispanic;Hispanic Americans;Homeostasis;Human;Human Engineering;human induced pluripotent stem cells;Individual;Inflammation;Inflammatory Bowel Diseases;interest;International;intestinal epithelium;Intestines;knock-down;Knock-out;Lead;Leadership;lipidomics;Massachusetts;member;metabolomics;microbiome analysis;Modeling;Molecular;molecular targeted therapies;Names;National Institute of Diabetes and Digestive and Kidney Diseases;Organoids;Participant;Pathogenesis;Patient Recruitments;Patients;Population;Population Heterogeneity;predicting response;Process;Productivity;prospective;protein protein interaction;Proteomics;Publications;Questionnaires;recruit;Relapse;Reporting;repository;Research;Research Personnel;Resources;response;risk variant;RNA Splicing;Role;Sampling;Serum;sex;single-cell RNA sequencing;Small Interfering RNA;stool sample;Techniques;Testing;Transcriptional Regulation;transcriptomics;treatment response;Ulcerative Colitis;Underrepresented Populations;University Hospitals;Variant;Visit;whole genome

PROJECT_TITLE: Montreal-Boston Collaborative GRC


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Muscular Dystrophy;Rare Diseases;Regenerative Medicine

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Project Narrative/Public Health Relevance Statement Muscle fibrosis affects many patients due to progressive loss of muscle strength and impaired mobility. There is no effective treatment. We will develop therapeutic strategies to treat muscle fibrosis by delivering mesenchymal stromal cells in specifically engineered hydrogel coatings.

PI_NAMEs: WONG, SING-WAN  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Advisory Committees;Affect;Alginates;animal imaging;Biochemical;Biocompatible Materials;Biodistribution;Biomedical Engineering;biophysical techniques;Biophysics;Bone Marrow;career development;Cell Therapy;Cell Volumes;Cells;Chemicals;Cicatrix;Clinical;Clinical Trials;Collagen;collagenase 3;Committee Members;confocal imaging;Cues;cytokine;Data;Deposition;design;Diffusion;Disease;Disease Progression;dysadherin;effective therapy;Encapsulated;Engineering;Ensure;Environment;experience;Extracellular Matrix;Fibrosis;Functional disorder;functional restoration;Gastrocnemius Muscle;Gel;Goals;Hydrogels;Image;immunoregulation;Impairment;improved;in vivo;Individual;Inflammatory;Injectable;Injections;Integrins;Interstitial Collagenase;Ischemia;Kinetics;Knowledge;Laboratories;Ligands;Marrow;mdx mouse;mechanical signal;Mechanics;Mediating;member;mesenchymal stromal cell;meter;Methods;Microfluidics;miniaturize;Mobility decline;Modeling;Molecular;Mus;Muscle;Muscle function;muscle regeneration;muscle strength;Muscular Atrophy;Muscular Dystrophies;muscular dystrophy mouse model;Myopathy;NF-kappa B;novel;novel therapeutic intervention;Organ;Oxidative Stress Induction;paracrine;Patients;Phase;prevent;Process;Production;programs;Property;public health relevance;Publishing;Recombinants;Regenerative Medicine;Reperfusion Therapy;Research Personnel;Research Project Grants;response;RGD (sequence);RNA delivery;RNA Interference;Role;Signal Transduction;Skeletal bone;Skeletal Muscle;Specific qualifier value;stem cells;success;Technology;Testing;Therapeutic;Thick;Thinness;tissue regeneration;Tissues;TNF gene;TNFRSF1A gene;Tumor Necrosis Factor Receptor;viscoelasticity;Work

PROJECT_TITLE: Engineering Mesenchymal Stromal Cells to treat Muscle Fibrosis

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: Relevance Gastroparesis and functional dyspepsia are disorders that predominantly affect younger women and have a very serious impact on quality of life and This research will help find new ways to diagnose and treat these conditions.

PI_NAMEs: PASRICHA, PANKAJ J (contact)

PROJECT_TERMS: Abdominal Pain;Address;Adult;Affect;antagonist;Biopsy;Black Box;blood glucose regulation;Childhood;Chronic;Clinical;Clinical Research;Clinical Trials;Data;diabetic gastroparesis;Diagnosis;Disease;DNA Repository;Dyspepsia;early satiety;Foundations;Functional disorder;Gastrointestinal Diseases;Gastrointestinal Motility;Gastroparesis;Goals;GPR4 gene;Human;Immune;improved;insight;Interstitial Cell of Cajal;Learning;Macrophage;Macrophage Activation;Malnutrition;Maps;Molecular;multiple omics;Myenteric Plexus;Nausea;Nausea and Vomiting;novel therapeutics;Nutritional Requirements;Nutritional Support;Outcome;Pathology;patient population;Patients;pediatric patients;phase 2 study;phase 3 study;Pioglitazone;Population;Quality of life;receptor;Registries;Research;Research Personnel;response;Role;Science;Serum;Stomach;symptom treatment;Symptoms;Syndrome;Techniques;Thick;Time;Tissues;young woman

PROJECT_TITLE: Advancing Science for the Diagnosis and Treatment of Gastroparesis


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Complementary and Integrative Health;Health Effects of Indoor Air Pollution;Hyperbaric Oxygen;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Carbon monoxide (CO) poisoning is a leading cause of death from environmental poisoning worldwide and is associated with high morbidity and mortality. Among survivors, permanent neurological morbidity is common even with prompt treatment. The objectives of this grant proposal are as follows: 1) to evaluate the use of circulating blood cells as a biomarker of severity in CO poisoning along with novel noninvasive optical measuring devices; 2) Among animals surviving 24 hours and 7 days post-CO exposure, further define cardiac and cerebral mitochondrial dysfunction, cerebral and cardiac metabolism, and clinically-relevant outcomes with those treated with hyperbaric oxygen (HBO) and those untreated with HBO; and 3) to test a promising mitochondria-directed therapy to preserve cellular energy production compared to HBO therapy with promising in vitro and in vivo data.

PI_NAMEs: JANG, DAVID H (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Acute;Address;Affect;Alternative Therapies;Animal Model;Animals;Applications Grants;Award;Behavior assessment;Behavioral;Biological Markers;biomarker development;Blinded;Blood Cells;Carbon Monoxide;Carbon Monoxide Poisoning;Carboxyhemoglobin;Cardiac;Cause of Death;Cell Physiology;Cells;Cerebrovascular Circulation;Cerebrum;Chronic;Cities;clinical application;clinical biomarkers;Clinical Trials;clinically relevant;Complex;complex IV;cytochrome c oxidase;Data;Devices;Diagnostic;disability;Disease Marker;Dose;efficacy outcomes;Engineering;Evaluation;exhaust;Exhibits;Exposure to;Extramural Activities;Family suidae;Fire - disasters;Functional disorder;Funding;Goals;Health;Heart Injuries;heart metabolism;Hemoglobin;Home;Hour;Hyperbaric Oxygen;Hyperbaric Oxygenation;Hypoxia;Image;In Vitro;in vivo;Inflammation;innovation;Institution;Intervention;Intervention Trial;Liquid substance;Magnetic Resonance Imaging;Measures;Methods;Mitochondria;mitochondrial dysfunction;Modeling;Monitor;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Nervous System Trauma;Neurocognitive;Neurocognitive Deficit;Neurologic;novel;novel strategies;novel therapeutic intervention;Optics;Outcome;Oxidation-Reduction;Oxygen;Oxygen Therapy Care;Pathway interactions;Patients;Permeability;Persons;Pharmacologic Substance;Physiological;Poisoning;porcine model;pre-clinical;Predictive Value;preservation;Prodrugs;Production;Prognosis;Publications;Randomized;Respiration;response;Role;Severities;Severity of illness;Succinates;Survivors;Sus scrofa;System;Technology;Testing;Therapeutic;therapeutic development;Time;tissue respiration;Translations;treatment effect;treatment response;treatment strategy;United States;Work

PROJECT_TITLE: The Use of Blood  Cells and Optical Cerebral Complex IV Redox States in a Porcine Model of CO Poisoning with Evaluation of Mitochondrial Therapy

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Disability Research;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Physical Activity;Physical Rehabilitation;Rehabilitation

ORG_CITY: ATLANTA

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Diabetic peripheral neuropathy is the most common complication in people living with diabetes, which causes limitations in functional mobility, decreased quality of life, and increased risk for ulceration and amputation. This career development award will evaluate the biomechanical and functional inter-relationships between plantar pressure and propulsion, surrogates of ulcer risk and walking function, and examine the feasibility and safety of using real-time biofeedback as a gait training intervention to break the cycle of disability in people with diabetic peripheral neuropathy. A thorough understanding of the underlying mechanisms contributing to walking dysfunction and evaluation of a preliminary gait training intervention can help develop improved gait rehabilitation approaches for individuals with diabetic peripheral neuropathy.

PI_NAMEs: RENDOS, NICOLE KRISTEN (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Address;Adult;Affect;Age;Amputation;Ankle;ankle joint;Biofeedback;Biofeedback Training;biomechanical test;Biomechanics;burden of illness;Characteristics;Clinical;Clinical Management;Clinical Trials;Clinical Trials Design;Communities;Complication;Complications of Diabetes Mellitus;Cutaneous;Data;design;Diabetes Mellitus;diabetic;Diabetic Foot;disability;Disease;dosage;Dose;Educational Intervention;Epidemiology;Esthesia;Evaluation;exercise program;Feedback;foot;Foot Diseases;Foot Ulcer;Fostering;Functional disorder;Future;Gait;Gait abnormality;gait rehabilitation;Generations;Goals;Health;Hypesthesia;improved;Individual;individual patient;insight;Intervention;joint stiffness;K-Series Research Career Programs;kinematics;Kinetics;Knowledge;Life;Lower Extremity;Measurement;Measures;Mentors;Methods;Mission;multidisciplinary;multimodality;Outcome;Participant;Patients;Peripheral Nervous System Diseases;Persons;Phase;pressure;prevent;Process;Quality of life;rehabilitation strategy;Research;response;Risk;Safety;safety and feasibility;Scientist;Sensory impairment;Structure;Symptoms;Time;Training;Training Programs;Ulcer;United States;United States National Institutes of Health;Vision;Walking;walking program;walking speed;Work

PROJECT_TITLE: Walking Function in Individuals with Diabetic Peripheral Neuropathy: Biomechanical Mechanisms and Implications for Clinical Outcomes and Gait Retraining

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


NIH_SPENDING_CATS: Cancer

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative This project seeks to accelerate the identiﬁcation of patient-speciﬁc therapeutic targets by harnessing new mea- surement techniques from tissue biopsies.

PI_NAMEs: NAEGLE, KRISTEN M (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Acceleration;Algorithms;Area;Biopsy;Brain;Breast;Cancer Model;Cell Physiology;Cells;Clinic;Clinical;Communities;Complement;Data;Data Set;Development;drug development;Enzymes;ERBB2 gene;Evaluation;experience;experimental study;Failure;FDA approved;Feedback;flexibility;Funding;Genetic;Goals;Graph;HER2 inhibition;Hour;Human;immune cell infiltrate;Immune signaling;Immunotherapy;improved;inhibitor therapy;Internet;kinase inhibitor;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Memory;Methods;Molecular;Mus;novel strategies;Oncology;patient response;Patients;Pharmaceutical Preparations;Phenotype;phosphoproteomics;Phosphorylation Site;Phosphotransferases;Physiological;Post-Translational Protein Processing;Pre-Clinical Model;precision medicine;Prostate;Proteins;Proteomics;Regulation;Research;Research Personnel;Resistance development;Resources;response;Serine;Signal Transduction;Solid;Solid Neoplasm;Speed;standard of care;statistics;Techniques;Testing;therapeutic target;therapy resistant;Threonine;Tissues;Translations;treatment response;tumor;tumor progression;Tyrosine Phosphorylation;usability;Visualization;web based interface;Work

PROJECT_TITLE: Inferring Kinase Activity from Tumor Phosphoproteomic Data


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Infant Mortality;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Necrotizing enterocolitis is a life-threatening intestinal disease in premature infants that is caused by immature intestine, aberrant bacterial colonization, and exaggerated inflammation. While no treatment options currently exist, our studies show that placental stem cell therapy is a multi-faceted approach that can ameliorate NEC damage through immunomodulation and epithelial regeneration. This proposal seeks to define the reparative cellular and molecular mechanisms and modes of actions involved in the immune modulation and epithelial resolution of NEC damage mediated by human placental stem cells.

PI_NAMEs: WEIS, VICTORIA  (contact)

PROJECT_TERMS: Address;Affect;Animal Disease Models;Attenuated;attenuation;Biological Models;Budgets;career;career development;Caring;Cell Separation;Cells;Cellular biology;Childhood;Clinical;clinical development;clinical translation;Clinical Treatment;combat;Data;Death Rate;Development;Development Plans;Disease;disease model;Doctor of Philosophy;effective therapy;Engraftment;Ensure;Environment;Epithelial Cells;epithelial repair;Epithelium;epithelium regeneration;Foundations;Gastroenterology;gastrointestinal;Goals;Grant;Growth;healing;high risk;Human;human disease;Image;Immune;Immune response;immunoregulation;improved;In Vitro;in vitro Model;in vivo;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;Inflammatory Response;innovation;Intestinal Diseases;intestinal epithelium;Intestines;Investigation;investigator training;K-Series Research Career Programs;laboratory experience;LGR5 gene;Life;Lymphocyte;Lymphocyte Subtypings;Measures;Medial;Mediating;Mentored Research Scientist Development Award;Mentors;Mesenchymal;Modeling;Molecular;molecular dynamics;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Natural regeneration;Necrotizing Enterocolitis;Neonatology;novel;novel therapeutics;Operative Surgical Procedures;Organ;Paracrine Communication;Pathogenicity;Pathway interactions;patient population;Perinatal;Personnel Management;Placenta;placental stem cell;Population;premature;Premature Infant;prevent;Prevention;Process;Proliferating;pup;Rattus;Recovery;regeneration function;Regulation;Regulatory T-Lymphocyte;repaired;reparative process;Reproducibility;Research;Research Personnel;Resected;Resolution;restoration;Risk Factors;Role;Signal Transduction;skills;skills training;stem cell niche;stem cell survival;stem cell therapy;stem cells;Survival Rate;Targeted Research;targeted treatment;Therapeutic;therapeutic candidate;therapeutic development;Therapeutic Effect;Therapeutic Research;therapeutically effective;therapy development;Time;Tissues;Translating;Translational Research;translational therapeutics;Translations;Writing

PROJECT_TITLE: Therapeutic Mechanisms of Placental Stem Cell-Based Therapy in Necrotizing Enterocolitis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: GM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Asexual reproduction has emerged many times across eukaryotes, but very little is known about the genetic mechanisms behind this major shift in biology. In addition to numerous pathogens that use asexual reproductive strategies, asexual reproduction serves as a key model for understanding the cell biology of meiosis and mitosis, and, processes such as cancer tumor evolution and fertility. The proposed research will leverage highly tractable insect systems in which microbial symbionts regulate reproductive mode to uncover the genetic basis of altered mitosis and meiosis and map the long-term evolutionary and genomic consequences of lost sex.

PI_NAMEs: LINDSEY, AMELIA RYAN ISIS (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Appearance;Arthropods;asexual;Asexual Reproduction;asexuality;Bacteria;Bacterial Proteins;Biological Models;Biology;Cell division;Cellular biology;comparative genomics;Creativeness;Defect;Degenerative Disorder;Development;Drosophila genus;Drug resistance;Environment;Eukaryota;Evolution;Fertility;forward genetics;Gene Pool;Genetic;Genetic Variation;genome sequencing;Genomic approach;Genomics;Goals;Health;Human;Inherited;Insecta;Interdisciplinary Study;invention;Link;Malignant Neoplasms;Maps;Mediating;Meiosis;Microbe;microbial;Mitosis;Mitotic;Modeling;Molecular;novel;novel therapeutics;Organism;Parthenogenesis;pathogen;Pathogenesis;Pathogenicity;Ploidies;Process;Proteins;Quantitative Trait Loci;Reproduction;reproductive;Reproductive Biology;Research;Rickettsia;sex;Sex Functioning;Sexual Reproduction;symbiont;System;theories;trait;tumor;Wolbachia;Yeasts

PROJECT_TITLE: Causes and consequences of microbe-mediated asexuality

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Behavioral and Social Science;Data Science

PHR: Project Narrative: The project team will develop a training program to teach skills and tools for rigor and reproducibility in biomedical data science, through a bootcamp with a flexible syllabus and collaborative projects, follow-on mentoring, and an online bilingual study guide that is interactive and self-paced. The trainees will be teams of faculty and technical personnel who will collaborate in the learning process and complement each other’s skills and perspectives. The program will strengthen trainees’ research and enable them to teach rigor and reproducibility at their institutions, which could be especially important for researchers from underrepresented groups and institutions with limited resources.

PI_NAMEs: GUTIERREZ, JUAN B;LIU, JING  (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: adaptive learning;Address;Applications Grants;Awareness;bilingualism;biomedical data science;Biomedical Research;career;Collaborations;Communities;Complement;complex data;computerized data processing;Data;Data Analyses;Data Collection;data management;Data Science;data sharing;Data Sources;design;E-learning;educational atmosphere;Educational Curriculum;Educational process of instructing;Ensure;Ethical Issues;Face;Faculty;flexibility;Friends;Fruit;Funding Agency;Goals;health record;heterogenous data;Human Resources;improved;Individual;innovation;insight;Institution;Instruction;instructor;Investigation;Journals;Judgment;Learning;lectures;Life Cycle Stages;Mentors;Meta-Analysis;Metadata;Methodology;minority investigator;Minority-Serving Institution;online course;Outcomes Research;Persons;Phase;Play;Population;predictive modeling;Process;Professional Organizations;programs;recruit;Reporting;Reproducibility;Research;Research Personnel;Research Project Grants;research study;Resources;Role;Shapes;skill acquisition;skills;Societies;sound;Spanish/English;Stress;Teacher Professional Development;Technical Expertise;Thinking;Time;tool;Trainers Training;Training;Training Activity;Training Programs;Underrepresented Populations;Universities;Work

PROJECT_TITLE: Training Biomedical Research Teams for Rigor and Reproducibility in Data Science


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE We propose to build upon an ongoing collaboration between the Health Care Systems Research Network (HCSRN) and the Claude D. Pepper Older Americans Independence Centers (OAICs) to expand a national resource created to pursue an interdisciplinary research agenda focused on the needs of older adults with multiple chronic conditions. Our efforts will ultimately translate into the delivery of higher quality, person- centered care for this growing population of older Americans.

PI_NAMEs: GURWITZ, JERRY H (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Administrative Supplement;Aducanumab;Aging;Alzheimer's Disease;American;Anemia;Award;Capsicum;care systems;career;career development;Caregivers;Caring;Clinical Research;Clinical Trials;cohort;Collaborations;collaboratory;comorbidity;COVID-19 pandemic;Data;Data Sources;Dementia;Development;Education;Educational Curriculum;Educational workshop;Elderly;equity, diversity, and inclusion;Exploratory/Developmental Grants Phase II;Feedback;Fostering;Funding;Geriatrics;Grant;Growth;health care delivery;health equity promotion;Health Personnel;Healthcare Systems;Heart failure;human old age (65+);improved;Infrastructure;innovation;instrument;Interdisciplinary Study;Intervention Trial;Knowledge;Libraries;Measures;member;Mentors;Mentorship;Methods;Minority;minority scientist;Mission;multiple chronic conditions;National Institute on Aging;next generation;novel;Nursing Homes;older adult;Older Population;Paper;patient engagement;patient oriented;Patients;person centered;Persons;Pilot Projects;Policies;Population;Pragmatic clinical trial;pragmatic intervention;pragmatic trial;Principal Investigator;Process;Productivity;programs;Publishing;recruit;Research;Research Activity;Research Design;Research Personnel;Resources;response;Scholars Program;Science;Scientist;Societies;success;symposium;synergism;systems research;Translating;Translational Research;Translational trial;Translations;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Voice

PROJECT_TITLE: Advancing Geriatrics Infrastructure and Network Growth (AGING) Initiative


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Women with diabetes and breast cancer have a 50% higher risk of death up to 10 years after cancer diagnosis compared to non-diabetic women with breast cancer, which may be partially due to suboptimal diabetes management during active cancer treatment. The goal of this study is to develop and pilot test a stakeholder- engaged intervention to manage diabetes for women receiving chemotherapy for incident, non-metastatic breast cancer. Findings from this innovative pilot study will lay the groundwork for a future, multi-site, randomized trial testing the intervention developed here.

PI_NAMEs: PINHEIRO, LAURA C (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: 2,4-Dinitrophenol;Active Learning;Acute;Affect;aggressive breast cancer;Attention;Award;blood glucose regulation;Breast;Breast Cancer Patient;Breast Cancer therapy;Breast Cancer Treatment;cancer care;cancer diagnosis;cancer health disparity;Cancer Patient;cancer therapy;career development;Caring;chemotherapeutic agent;chemotherapy;Chemotherapy-Oncologic Procedure;Chronic Disease;Clinical;Cluster randomized trial;Communities;comorbidity;design;Development Plans;diabetes control;diabetes management;Diabetes Mellitus;Disparity;Doctor of Philosophy;effectiveness testing;Endocrinologist;Ensure;ethnic disparity;ethnic minority;Evaluation;Face;Feeling;Future;glycemic control;Goals;Grant;Health;health care delivery;health disparity;health equity;Health Services;health training;High Prevalence;high risk;Hospitalization;implementation evaluation;implementation outcomes;implementation science;implementation trial;improved;improved outcome;Individual;Infection;innovation;Inpatients;interest;Internist;Intervention;Malignant Breast Neoplasm;Malignant Neoplasms;Medicine;Mentors;Mentorship;Modeling;mortality;mortality risk;multidisciplinary;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Nonmetastatic;Nurse Practitioners;Oncologist;Oncology;Oncology Nurse;Outcome;outcome disparities;Patient Care;Patient-Focused Outcomes;Patients;Phase;Pilot Projects;pilot test;Primary Care;primary care provider;Primary Nursing Care;Provider;Qualitative Research;racial disparity;racial minority;randomized trial;Reading;Reduce health disparities;Reporting;Research;Research Methodology;Research Personnel;Risk;Scientific Inquiry;Scientist;Site;skills;success;Testing;therapy design;Training;Uncertainty;United States Dept. of Health and Human Services;Woman;Work;Writing

PROJECT_TITLE: Optimizing the Delivery of Diabetes Management During Breast Cancer Care

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The current project aims to better understand the psychological processes that lead to alcohol use and its consequences during adolescence and early adulthood. Our goal is to compare the relative importance of four key factors thought to promote addiction, and to understand how their influence changes over time. Findings from such work can lead to new, targeted addiction interventions.

PI_NAMEs: BARTHOLOW, BRUCE D (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Acceleration;Accounting;addiction;Adolescence;Adolescent;Affect;Age;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol involvement;alcohol use disorder;Anxiety;Behavioral;cognitive control;cohort;Consumption;Data Collection;Data Set;data structure;design;Development;Diagnosis;disease classification;Disinhibition;drinking;Ecology;emerging adult;emerging adulthood;Enrollment;Etiology;Failure;Female;Goals;Heavy Drinking;Heterogeneity;Impairment;incentive salience;indexing;Individual;Individual Differences;individualized prevention;Intervention;Knowledge;Lifestyle-related condition;Link;longitudinal design;Maps;Measures;Modality;Modeling;multimodality;neuroadaptation;neurobehavioral;neurophysiology;Outcome;Participant;Patient Self-Report;Pattern;personalized intervention;personalized medicine;Persons;Phenotype;Play;Process;prospective;Prospective Studies;psychologic;Research;Research Domain Criteria;Research Personnel;Rewards;Risk;Role;Sampling;Severities;Shapes;social;Social Environment;Suggestion;symptom cluster;Symptoms;Testing;theories;Time;treatment strategy;Typology;Work

PROJECT_TITLE: Determining the Contributions of Four AARDoC Functional Domains to the Etiology of Heavy Drinking and AUD Symptoms: A Prospective, Multimodal Approach


NIH_SPENDING_CATS: Cancer;Immunotherapy;Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Understanding the pre-analytical variables that influence tissue-based biomarker tests is of utmost importance for validity and precision of the measurements. This project will systematically and comprehensively evaluate patient factors and tissue specimen pre-analytics for their effects on the validity, sensitivity, and specificity of singleplexed and multiplexed immunohistochemical predictive PD-L1 biomarker assays. This project will define the best pre- analytical conditions for specimen acquisition and inform a biomarker testing paradigm for the next generation of clinical tissue-based immune checkpoint protein assays for the benefit of cancer patients.

PI_NAMEs: ROEHRL, MICHAEL H. A. (contact)

PROGRAM_OFFICER_NAME: GUAN, PING

PROJECT_TERMS: 4 year old;Acceleration;Address;Affect;Age;Alcohols;Anti-emetics;anti-PD-L1;Asian;biobank;Biological Assay;Biological Markers;Biopsy;Black race;Body mass index;Cancer Patient;cancer type;Categories;cell type;Characteristics;Clinic;Clinical;clinical practice;cohort;Collaborations;contextual factors;Cytotoxic Chemotherapy;Data;Databases;Dependence;diagnostic assay;Eastern Cooperative Oncology Group;Ensure;Ethnic Origin;Evaluation;Excision;Face;Formalin;Freezing;gastroesophageal cancer;Gender;Goals;Guidelines;Health Care Costs;Hispanic;histological slides;Ice;immune checkpoint;Immunohistochemistry;immunological status;Immunooncology;Immunotherapy;innovation;Ischemia;Knowledge;Length;Lymphocyte;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measurement;Measures;Melanoma;Memorial Sloan-Kettering Cancer Center;Molecular;multiplex assay;neoplastic cell;next generation;Non-Small-Cell Lung Carcinoma;Outcome;overtreatment;Paraffin Tissue;patient variability;Patients;Performance;Performance Status;personalized diagnostics;personalized health care;Pharmacotherapy;Physiological;predictive marker;predictive test;preservation;Procedures;Process;programmed cell death ligand 1;Prospective cohort;Prospective Studies;protein expression;Proteins;Protocols documentation;Qualifying;Radiation;Research;sample fixation;Sampling;Site;Solid;Specificity;Specimen;Steroids;Temperature;Testing;Time;tissue fixing;Tissue Sample;Tissues;Translations;tumor;Tumor Tissue;Variant

PROJECT_TITLE: Evaluation of Patient Factors and Sample Pre-Analytics on Predictive Multiplex Immunohistochemical Assays in Immuno-Oncology Patients


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative This project will increase our understanding of how each individual's clinical measures and biomarkers would predict the time of progression to AD dementia from MCI. We will develop optimal deep survival models for early stage and late stage MCI patients. This project will greatly speed up the time it would take to identify potential MCI patients who are more likely to develop AD dementia in later years.

PI_NAMEs: SHAN, GUOGEN  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease patient;Alzheimer’s disease biomarker;Amyloid beta-Protein;Biological Markers;Cerebrospinal Fluid;Clinical;Clinical Data;Clinical Research;Clinical Trials;cohort;cost;Data;deep learning;Dementia;Diagnosis;Disease;drug development;drug testing;Event;falls;follow-up;Funding;Future;Glial Fibrillary Acidic Protein;hazard;high risk;Impaired cognition;improved;indexing;Individual;interest;Magnetic Resonance Imaging;Measures;Memory Loss;Methods;mild cognitive impairment;Modeling;Modernization;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;nonalzheimer dementia;novel;Outcome;Parents;Participant;Patient Care;Patients;Performance;Pharmaceutical Preparations;Phosphorylation;Placebos;Plasma;Play;Positron-Emission Tomography;potential biomarker;pre-clinical;predictive modeling;Process;programs;Property;Reporting;Research Project Grants;research study;Risk Factors;Sampling;Speed;Subgroup;Survival Rate;tau Proteins;tau-1;Techniques;Testing;theories;Time;time interval;tool;translational neuroscience;United States National Institutes of Health;Validation;Visit;web site

PROJECT_TITLE: Application of deep learning and novel survival models to predict MCI-to-AD dementia progression

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Prevention;Social Determinants of Health;Stroke

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Results from the study will provide clinicians, investigators, and policymakers with national data on rates, trends, and patterns of outcomes after ischemic stroke among Medicare beneficiaries, including variation among patient subgroups and geographic regions.

PI_NAMEs: LICHTMAN, JUDITH H (contact)

PROJECT_TERMS: Address;Adult;adverse outcome;Age;age related;Aging;aging demography;American;American Heart Association;American Stroke Association;Area;beneficiary;cardiovascular health;cardiovascular risk factor;Cardiovascular system;care providers;Caring;Cause of Death;Cessation of life;Characteristics;Clinical;clinical practice;Communities;community intervention;community-level factor;comorbidity;cost;County;Data;data resource;Data Set;Databases;Diagnostic tests;disability;disabled;Disease;Disparity;disparity elimination;Elderly;Event;Family;Fee-for-Service Plans;follow-up;functional disability;Geographic Locations;Goals;Grant;Guidelines;Health;health care availability;health disparity;Health Insurance;Health Resources;Health Status;Healthcare Systems;Heart Diseases;Heterogeneity;High Prevalence;high risk;Hospitalization;human old age (65+);improved;Inequity;Institute of Medicine (U.S.);Institution;Insurance Carriers;Investigation;Ischemic Stroke;Link;Longterm Follow-up;Medicare;Modeling;mortality;national surveillance;Neurologic Deficit;Outcome;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Policy Maker;Population;population based;Populations at Risk;post stroke;prevent;Prevention strategy;programs;Public Health;Public Policy;Recovery;Recurrence;Reporting;Research Personnel;residence;Resources;Risk;Role;Societies;sociodemographic disparity;sociodemographic factors;sociodemographics;Socioeconomic Status;Source;Stroke;stroke event;stroke incidence;stroke outcome;stroke risk;stroke survivor;Subgroup;System;Time;trend;United States;Variant;vascular risk factor

PROJECT_TITLE: Disparities in Patterns of Recurrent Stroke in the Elderly

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]