ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics;Regenerative Medicine;Wound Healing and Care

ORG_CITY: BOSTON

ORG_DEPT: DENTISTRY

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Diabetic bone disease (DBD) characterized by substantial high fracture risk represents a major complication of type 2 diabetes (T2D) afflicting 40 million people in the US and 370 million in the world. Long noncoding RNAs (lncRNAs) are a family of non-protein-coding transcripts playing important roles in gene expression and pathogenesis of many human diseases. We have recently discovered and characterized a new lncRNA, lncR-DBD, which targets the major etiopathogenesis of DBD and emerges as a novel, efficient and effective therapeutic remedy for the epidemic DBD.

PI_NAMEs: CHEN, JAKE JINKUN (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Anti-diabetic Drugs;Binding Proteins;Biocompatible Materials;Biological Process;Biology;Biomechanics;bisphosphonate;Blood Glucose;bone;bone cell;Bone Diseases;bone fracture repair;bone healing;bone metabolism;Bone Regeneration;Bone Resorption;Bone Tissue;Boston;Calcitonin;Cell Physiology;cell type;Cellular biology;Chondrocytes;Clinic;Clinical Trials;Code;Coin;Complication;Data;Defect;Development;Diabetes Mellitus;diabetic;diabetic bone disease;Diabetic mouse;Disease;Dose;Drug Delivery Systems;Drug Targeting;efficacy evaluation;Epidemic;Epigenetic Process;Experimental Pathology;Family;Foundations;fracture risk;Functional disorder;Future;Gene Expression;Genes;Health;histone methylation;human disease;Hyperglycemia;Impaired wound healing;Incidence;knockout gene;Knockout Mice;Laboratories;Length;Link;lipid biosynthesis;loss of function;Lysine;Methods;Molecular;Molecular Biology;mouse model;Mus;nanoparticle;Natural regeneration;New Jersey;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Nucleotides;Osteoblasts;Osteoclasts;Osteogenesis;osteogenic;Outcome;Pathogenesis;Pathologic;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;posttranscriptional;prevent;PTH gene;recruit;Research;Research Personnel;RNA;RNA Binding;Role;Selective Estrogen Receptor Modulators;side effect;Site;skills;System;Techniques;Technology;Therapeutic;Therapeutic Effect;therapeutic RNA;therapeutic target;therapeutically effective;tissue repair;Transcript;Transcription Process;translational study;Universities;Untranslated RNA;wound healing

PROJECT_TITLE: Therapeutic Potentials of a New Long Noncoding RNA in Diabetic Bone Wound Repair

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HONOLULU

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PI_NAMEs: OKAMOTO, SCOTT KIYOSHI (contact)

PROJECT_TERMS: Acceleration;Address;Asian Americans;Award;Basic Science;biobehavior;Biomedical Research;Biometry;Cancer Center;Chronic;Clinical;clinical infrastructure;Clinical Research;clinical translation;Collaborations;Communities;community engagement;community organizations;Community Outreach;Data;design;Development;disorder prevention;early onset;Eligibility Determination;Epidemiology;ethnic minority;Ethnic Origin;Evaluation;experience;Extramural Activities;Face;Faculty;federal policy;Filipino;Financial Support;Funding;Funding Agency;Geography;Goals;Grant;Guidelines;Hawaii;Health;health disparity;Health Expenditures;Homelessness;Immigrant;improved;Indigenous;innovation;Institution;Investments;Knowledge;Leadership;Mainstreaming;medically underserved population;Mental Health;mid-career faculty;Minority-Serving Institution;Modeling;Monitor;multi-ethnic;National Institute of Drug Abuse;National Institute of General Medical Sciences;National Institute on Aging;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Nature;Outcome;Patient Care;Performance;Persons;physical conditioning;Pilot Projects;Positioning Attribute;Premature Birth;Principal Investigator;Procedures;Process;Productivity;professor;programs;Public Health;racial minority;Reduce health disparities;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Rural;Schools;Science;Secure;Sexual and Gender Minorities;Social Work;sociocultural determinant;substance abuse prevention;substance use;System;Time;Translating;Translational Research;undergraduate research;Underserved Population;United States National Institutes of Health;Universities;vulnerable community;Vulnerable Populations;Woman;young adult;Youth

PROJECT_TITLE: Pilot Projects Program


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Embryonic and tissue development requires the tight spatiotemporal regulation of morphogenic movements in order to properly instruct cell fates. While a widely used cellular shape change involved in morphogenesis is apical constriction, the mechanisms by which it is regulated in mammals are largely unknown. Our investigations will uncover conserved and distinct apical constriction regulators in several mammalian morphogenic events.

PI_NAMEs: SUMIGRAY, KAELYN D. (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Apical;Architecture;Automobile Driving;Behavior;Biophysics;Cell Culture Techniques;Cell Differentiation process;Cell Shape;Cells;Complex;constriction;Cues;Development;Developmental Process;Dimensions;Disparate;Embryo;Ensure;Environment;Event;flexibility;gastrulation;Genetic;Genetic Transcription;insight;intestinal crypt;Intestines;Invertebrates;Investigation;Knowledge;Learning;Licensing;Mammals;Mechanics;model organism;Modeling;Molecular;Morphogenesis;Movement;Mus;Neural tube;novel;Pathway interactions;Pattern;Positioning Attribute;Primitive Streaks;Process;Proliferating;protein protein interaction;Proteins;Regulation;Research;Shapes;spatiotemporal;stem cell differentiation;System;Tissues

PROJECT_TITLE: Mechanics of mammalian morphogenesis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PI_NAMEs: MICHOR, FRANZISKA  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Affect;Biological Models;Blood capillaries;Blood Circulation;Blood Vessels;Cell Nucleus;Cell Survival;Cells;Chromatin;Chromatin Structure;Collaborations;Computer Models;Data;Dedications;Disease;DNA;electron tomography;Event;Exposure to;Extravasation;Fostering;Future;Gene Expression;Genes;Genetic Transcription;Genome Mappings;Genomics;HDAC3 gene;Hi-C;Image;Imaging technology;In Vitro;in vitro Model;in vivo;in vivo Model;Infrastructure;interest;Label;Lead;Link;mechanical properties;Mechanical Stress;Mechanics;Microscopic;Microscopy;migration;Modeling;Molecular;Molecular Conformation;mRNA sequencing;nanoimaging;nanoscale;Nanoscopy;nanosensors;Neoplasm Metastasis;neoplastic cell;Nuclear;Nucleosomes;operation;optical nanoscopy;Optics;Organ;Pattern;Phenotype;predictive modeling;Process;programs;Property;Resolution;Role;Scanning;Services;shear stress;Signal Pathway;single cell mRNA sequencing;single molecule;Stress;stressor;Technology;therapeutic target;Transcription Alteration;Transcription Process;transcriptional reprogramming;transcriptomics;Transmission Electron Microscopy;transmission process;Tumor Cell Migration;Validation;whole genome

PROJECT_TITLE: Core2:  Transcriptomics and Chromatin Structure


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: CHEMISTRY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative: A detailed understanding of human disease at the single cell level represents a challenging frontier, and very few measurement techniques are available to accurately quantify metabolites involved in all areas of human health. This MIRA application draws from our experience with nanoelectrochemistry, sensor development, and single cell analysis to innovate a generalizable platform to study metabolite concentrations in cellular compartments with minimal perturbation to cellular homeostasis.

PI_NAMEs: DICK, JEFFREY E (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TITLE: Nanoelectrochemistry and Single Cell Metabolomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: The Center for Tumor-Immune Systems Biology at MSKCC NARRATIVE Cancer immunotherapies are designed to harness the human immune system to attack cancer cells and eliminate tumors. Breakthroughs in cancer immunotherapy such as checkpoint blockade agents have revolutionized cancer care, but only a fraction of patients with specific tumor types respond to these new treatments. Our proposed Research Center will deploy tools from systems biology to improve our fundamental understanding of tumor-immune interactions in contexts where current immunotherapies fail and to develop novel strategies for enhancing responses in contexts where they have only partial success.

PI_NAMEs: LESLIE, CHRISTINA S (contact);RUDENSKY, ALEXANDER Y

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Address;Algorithmic Analysis;anti-cancer;Anti-Inflammatory Agents;Astrocytes;Award;Blood Vessels;Brain;Cancer Biology;cancer care;cancer cell;Cancer Center;cancer immunotherapeutics;cancer immunotherapy;Caspase;CD8-Positive T-Lymphocytes;Cell Death;Cells;Chromatin;Clear cell renal cell carcinoma;clinical care;Colon Carcinoma;Colorectal Cancer;Complex;Computational Biology;computer studies;Computing Methodologies;Data;Data Set;Dendritic Cells;design;Development;Disease associated microglia;Distal;Ecosystem;Education and Outreach;Educational workshop;Engineering;experimental study;Functional disorder;Genes;Genetic Transcription;graduate student;Human;Immune;immune checkpoint blockade;Immune response;Immune system;Immunofluorescence Immunologic;immunogenic;immunogenic cell death;Immunological Models;Immunologics;Immunology;Immunotherapeutic agent;Immunotherapy;improved;In complete remission;innovation;insight;Invaded;Investigation;learning strategy;lectures;Ligands;Link;Liver;Lung Adenocarcinoma;machine learning model;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Melanoma Cell;Memorial Sloan-Kettering Cancer Center;Metastatic Neoplasm to Lymph Nodes;Metastatic Neoplasm to the Leptomeninges;Methods;Mismatch Repair;Mitochondria;Modality;Modeling;Molecular Analysis;mouse model;multidisciplinary;Multiomic Data;multiple omics;novel;novel strategies;optical imaging;Organ;Patients;Process;programs;receptor;Refractory;refractory cancer;Renal Cell Carcinoma;Research;Research Personnel;Research Project Grants;Resistance;Resource Sharing;response;Role;Scientific Advances and Accomplishments;Scientist;Solid Neoplasm;standard of care;success;symposium;System;Systems Biology;T cell response;T memory cell;T-Lymphocyte;Technology;Therapeutic;tissue regeneration;tool;Training;Training Activity;Training Programs;transcriptomics;tumor;Tumor Immunity;tumor immunology;tumor-immune system interactions;undergraduate student


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Dissemination and Implementation Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research

PI_NAMEs: SY, ANGELA U (contact)

PROJECT_TERMS: Acceleration;Award;Benchmarking;Biology;Biometry;Centers for Disease Control and Prevention (U.S.);clinical application;Clinical Research;Collaborations;collaborative environment;Colorado;Communities;community engagement;community organizations;Community Outreach;community research;community setting;Consultations;Core Facility;culturally appropriate intervention;Data;design;Development;Dimensions;distinguished professor;Doctor of Philosophy;economic evaluation;economic impact;Effectiveness;Elements;Ensure;Epidemiology;Evaluation;Evaluation Research;experience;Filipino;formative assessment;Fostering;Funding;Goals;Grant;Hawaii;Health;Health Surveys;Healthcare Systems;higher education;Impact evaluation;implementation evaluation;improved;indexing;Indigenous;Individual;innovation;Institution;Investments;Knowledge;Lead;Measures;Medical;Medical center;medical schools;Mentors;Methods;Monitor;multidisciplinary;Native Hawaiian or Other Pacific Islander;Native-Born;Outcome;Outcome and Process Assessment;Outreach Research;Pathway Analysis;Performance;Personal Satisfaction;Persons;Physicians;Pilot Projects;Policies;Process;process evaluation;Productivity;professor;Program Evaluation;programs;Progress Reports;Public Health;Public Health Practice;Reduce health disparities;Research;Research Design;Research Infrastructure;Research Personnel;Resources;Science;Scientific Advances and Accomplishments;Scientist;Services;Social Network;sound;Strategic Planning;success;System;Time;tool;Translating;Translational Research;Universities;Washington

PROJECT_TITLE: Tracking and Evaluation Core


NIH_SPENDING_CATS: Cancer

PI_NAMEs: LESLIE, CHRISTINA S (contact)

PROJECT_TERMS: Administrative Efficiency;Adopted;Advisory Committees;Award;Collaborations;Communication;Communities;Data;data management;data sharing;Ensure;Faculty;Feedback;Funding;Goals;high school;Human Resources;Immune system;Infrastructure;Leadership;Malignant Neoplasms;Measures;Memorial Sloan-Kettering Cancer Center;Mentors;multidisciplinary;next generation;organizational structure;outreach;Pilot Projects;Postdoctoral Fellow;Procedures;programs;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Review Committee;Structure;System;Systems Biology;tool;Training;tumor;tumor immunology;undergraduate student;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative Despite the majority of college students being underage for drinking, almost 80% report consuming alcohol in the past year and more than 1 in 3 report heavy drinking in the past month. Reports also show college is a high-risk window for cannabis use and consequences (including using both substances in the same day), which is highly concerning considering that the potency of present-day cannabis has markedly increased and availability continues to grow due to increased legalization across the U.S. The proposed research will address these important public health problems by testing a modified version of our parent-intervention that includes content for parents to have broader discussions about alcohol and cannabis use.

PI_NAMEs: TURRISI, ROBERT J (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Acute;Address;Administrator;age group;Air;alcohol consequences;Alcohol consumption;alcohol measurement;Alcohols;Anxiety;assault;Attention;Behavior;Binding;binge drinking;Brain;Cannabis;Cardiovascular system;Cellular Phone;Cessation of life;Chronic;Cognition;Cognitive deficits;college;college drinking;Communication;Communities;Computers;Control Groups;cost;Data;Decision Making;design;Development;drinking;efficacy evaluation;endogenous cannabinoid system;Evaluation;evidence base;Family;Feedback;follow-up;Health;Health Surveys;Heavy Drinking;high risk;high risk drinking;high school;Home;Individual;Injury;interest;Intervention;Intervention Studies;laptop;Legal;Letters;Literature;marijuana legalization;marijuana use;marijuana user;Mediation;Mediator;member;Mental Depression;Mental Health;Methods;Military Personnel;Modeling;National Institute on Alcohol Abuse and Alcoholism;novel;parental influence;parenting intervention;Parents;Perception;Performance;physical conditioning;Population;post intervention;Prevention;Prevention strategy;Preventive;primary outcome;Process;Psychoses;psychosocial;Public Health;Publishing;randomized, clinical trials;Readability;reduced alcohol use;Reporting;Research;Resources;respiratory;Review Literature;Risk;secondary outcome;sex;skills;Sleep Disorders;Students;Subgroup;Surgeon;Surveys;Tablets;Teenagers;Testing;trend;underage drinking;Universities;university student

PROJECT_TITLE: A randomized clinical trial: Examining a brief parent-intervention to reduce college student drinking and cannabis use

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: WASHINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: A program in Aging and Alzheimer’s Research Training (AART) at Georgetown University will train PhD students and postdoctoral fellows in laboratory research into causes and connections of aging-related neurodegenerative diseases. The program will build on a wide array of current research laboratories at Georgetown University in aging and neurodegeneration, on clinical and neuropathological programs, on graduate aging coursework, on regional centers of aging and Alzheimer’s disease, and on a dynamic office for career development. The overall goal is to train students and fellows whose current research experience is related to, but not focused on, aging and Alzheimer’s disease research, and to foster advances in aging/AD research by promoting this interdisciplinary work.

PI_NAMEs: REBECK, G WILLIAM (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TITLE: Aging and Alzheimer's Research Training


NIH_SPENDING_CATS: Brain Disorders;Breast Cancer;Cancer;Genetics;Lung;Lung Cancer;Neurosciences;Rare Diseases;Women's Health Research

PI_NAMEs: MASSAGUE, JOAN  (contact)

PROJECT_TERMS: Adenocarcinoma Cell;Alzheimer's Disease;Apoptosis;Astrocytes;autocrine;Basement membrane;Binding;Blood Vessels;Brain;brain cell;brain shape;Breast Cancer Cell;cancer cell;Cancer Patient;Cell Communication;cell type;Cells;cerebral capillary;Clinical;Communication;Complex;contextual factors;differential expression;Disease associated microglia;Disseminated Malignant Neoplasm;ERBB2 gene;Exclusion;Extracellular Matrix Proteins;Factor Analysis;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Growth;Homeostasis;Immune;Immune system;Immunologist;knowledge of results;Label;Laminin;Lead;Learning;Logic;Lung Adenocarcinoma;lung colonization;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mediator;Memorial Sloan-Kettering Cancer Center;Metastatic malignant neoplasm to brain;Microglia;Modeling;Morbidity - disease rate;mortality;mouse model;multiple omics;Natural Immunity;Nature;Neoplasm Metastasis;Neural Cell Adhesion Molecule L1;Patients;pharmacologic;Phenotype;Physicians;prevent;Primary Neoplasm;programs;Research;Research Personnel;Resistance;response;Sampling;Shapes;Signal Transduction;single cell analysis;single-cell RNA sequencing;spatial relationship;spatiotemporal;System;Systems Analysis;Systems Biology;Testing;therapeutic development;therapeutic evaluation;Therapeutic Intervention;Tissues;Transcriptional Regulation;triple-negative invasive breast carcinoma;tumor;tumor growth;unpublished works

PROJECT_TITLE: Project I: Systems analysis of tumor-stroma interactions in brain metastasis


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Patient Safety;Substance Misuse

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: NARRATIVE  The proposed research is relevant to public health because it will provide a detailed picture of alcohol-induced changes in human drug-metabolizing ensemble and characterize system-wide changes in drug metabolism induced by alcohol exposure. The obtained knowledge will be instrumental for optimizing drug dozing regimes in alcohol consumers, and the drugs used in treatment of Alcohol Use Disorder and Alcohol Withdrawal Syndrome in particular. Besides providing new insights on the effects of alcohol on drug metabolism, this study will result in fundamental conceptual advancements in our understanding of complex cases of drug-drug and drug-alcohol interactions, adverse drug effects, and other alcohol-induced disorders with P450-dependent pathogenesis. Elaboration of the concept of function and regulation of the human drug-metabolizing ensemble as an integral multi-enzyme system, which is the long-term goal of our studies, is a matter of critical importance for in-depth understanding of the changes in human drug metabolism under influence of alcohol exposure and establishing a rational approach for optimal drug use under chronic alcohol exposure.

PI_NAMEs: DAVYDOV, DMITRI R (contact);PRASAD, BHAGWAT

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Adverse drug effect;Adverse effects;Affect;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol use disorder;Alcohol withdrawal syndrome;Alcohol-Induced Disorders;Alcohols;AODR mortality;Biological Assay;carcinogenesis;Chemicals;Chronic;Clinical;Cocaine;Collection;Complex;crosslink;CYP1A2 gene;CYP2C19 gene;CYP2C9 gene;CYP2D6 gene;CYP2E1 gene;CYP3A4 gene;Cytochrome P450;Diazepam;Drug Interactions;Drug Kinetics;drug metabolism;Drug Metabolism Induction;drug of abuse;Drug Prescriptions;Drug usage;Eicosanoids;Endoplasmic Reticulum;Enzyme Induction;Enzymes;Foundations;Genotype;Goals;Health;Hepatocyte;high throughput screening;Human;Hypertension;Individual;insight;intermolecular interaction;interspecies communication;Knowledge;Knowledge acquisition;Life;Liver;Liver Microsomes;Mass Spectrum Analysis;Mediating;Medical;Membrane;Metabolic;Metabolism;Minor;Opioid;Pathogenesis;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Phenytoin;Physiological;Play;Preparation;Prevention;Property;protein expression;protein protein interaction;Proteins;Proteomics;Public Health;Recording of previous events;Regulation;Research;Role;Route;Series;Signal Pathway;Signal Transduction;Substrate Specificity;System;Systems Integration;Therapeutic;Tissues;Tolbutamide;Tretinoin;Warfarin

PROJECT_TITLE: Inter-Enzyme Crosstalk in the Cytochrome P450 Ensemble: Implications for the Effects of Alcohol on Drug Metabolism and Alcohol-Drug Interactions

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Liver Disease;Lymphatic Research;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: RUDENSKY, ALEXANDER Y (contact)

PROJECT_TERMS: Ablation;Acute;Antibodies;Antigen-Presenting Cells;antitumor effect;Architecture;ATAC-seq;Biological Assay;cancer cell;carcinogenesis;Carcinogens;Cell Communication;Cell Nucleus;cell type;Cells;checkpoint therapy;chemokine;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Colon;colon cancer patients;Colon Carcinoma;Colorectal Cancer;colorectal cancer progression;Combination immunotherapy;combinatorial;Combined Modality Therapy;commensal microbes;Computer Analysis;Computer Models;Coupled;Cues;Development;Disease;Disease Progression;Disease Resistance;Distal;enteric infection;Epithelium;Equilibrium;experimental analysis;Exposure to;Failure;Flow Cytometry;Genes;Genetic;Genetic Models;Human;Immune;immune checkpoint blockade;Immune system;Immune Targeting;Immunity;immunoregulation;Immunotherapy;Inflammatory;Inflammatory Response;Intestines;Lead;Ligands;Liver;lymph nodes;lymphoid organ;Maintenance;Malignant Neoplasms;Mediating;Memorial Sloan-Kettering Cancer Center;metastatic colorectal;Metastatic Neoplasm to the Liver;microbiota;Microscopy;Mismatch Repair;Mismatch Repair Deficiency;Modality;mouse genetics;multiple omics;Mus;Mutagenesis;Neighborhoods;Neoplasm Metastasis;neoplastic cell;novel;optical imaging;Organoids;Patients;pharmacologic;prevent;Primary Neoplasm;programs;receptor;Recombinants;Regulatory T-Lymphocyte;Resolution;RNA;Role;Signal Pathway;Site;stem cell organoids;stem cells;Stimulus;Supporting Cell;Survival Rate;Systems Biology;T cell receptor repertoire sequencing;T-Lymphocyte;Testing;Therapeutic;Tissues;tool;transcriptome sequencing;transcriptomics;Transplantation;tumor;tumor progression

PROJECT_TITLE: Project II: Immune regulatory circuits in primary colon cancer and lymph node and liver metastases


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Prevention;Social Determinants of Health

PHR: This project aims to discover which aspects of the food environment and dietary behavior have influence on dietary intake and quality, and how they relate to Just-In-time intervention receptivity. An integrated system of wearable sensor and computational methods will be developed to capture and analyze the various exposures and patterns in the eating environment.

PI_NAMEs: SAZONOV, EDWARD S;ZHU, FENGQING MAGGIE (contact)

PROJECT_TERMS: Adult;Awareness;Behavior;Behavioral Sciences;Body part;Computer Hardware;Computer software;Computing Methodologies;Cues;Data;Data Analyses;Data Collection;design;Detection;Diet;dietary;dietary guidelines;Dietary intake;Dietary Practices;Disease;Eating;Eating Behavior;Environment;Environmental Exposure;Face;Feedback;food environment;Grain;Health;Health Care Costs;human model;Image;image processing;improved;Individual;Intervention;Learning;Life;Methods;Monitor;novel;Obesity;Outcome;Overweight;Participant;Pathway interactions;Pattern;Physical environment;Pilot Projects;power consumption;preventable death;privacy preservation;Research;Research Personnel;Semantics;Social Interaction;Stream;Systems Integration;Technology;technology development;Time;Training;transmission process;Unhealthy Diet;United States;Vision;Visual;wearable data;wearable device;wearable sensor technology;Work

PROJECT_TITLE: SCH: Wearable Sensing and Visual Analytics to Estimate Receptivity to Just-In-Time Interventions for Eating Behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Kidney Disease;Rare Diseases;Skin Cancer

PI_NAMEs: CHENG, EMILY H (contact)

PROJECT_TERMS: Abscopal effect;adaptive immune response;Affect;Allografting;anti-CTLA-4 therapy;anti-PD-1;Antigens;APAF1 gene;Apoptosis;BAX gene;BCL1 Oncogene;cancer care;cancer cell;cancer type;CASP9 gene;Caspase;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Death;Cell Line;Cell Membrane Permeability;Cell Nucleus;cell type;Cells;Clear cell renal cell carcinoma;Computer Models;cytochrome c;Cytosol;Dimensions;Distant;draining lymph node;Ecosystem;Engineering;Epigenetic Process;Evolution;Gene Expression;Genetic Engineering;Genetically Engineered Mouse;Goals;Human;Immune;immune checkpoint blockade;Immune response;Immune system;Immunofluorescence Immunologic;immunogenic;immunogenic cell death;immunogenicity;Immunologic Memory;Immunologics;Immunotherapy;improved;In complete remission;in vivo;Inflammatory;Inner mitochondrial membrane;insight;Interferon Type I;Label;Lead;Luciferases;Melanoma;Melanoma Cell;Memorial Sloan-Kettering Cancer Center;Mitochondria;Mitochondrial DNA;Modeling;Molecular;mouse model;multiple omics;Mus;Mutation;Necrosis;Neoplasm Metastasis;novel;Outer Mitochondrial Membrane;Pathway interactions;Patients;Probability;Process;programs;Protein Family;Recurrent tumor;Renal Cell Carcinoma;Research Personnel;Resolution;response;RNA;Sampling;Stimulator of Interferon Genes;success;survival outcome;System;Systems Biology;T cell receptor repertoire sequencing;T-cell receptor repertoire;T-Lymphocyte;The Cancer Genome Atlas;Therapeutic;Transplantation;tumor;tumor heterogeneity;Tumor Immunity;tumor progression

PROJECT_TITLE: Project III: Engineering immunogenic cell death in melanoma and renal cell carcinoma.


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Social Determinants of Health

PI_NAMEs: SHIKUMA, CECILIA M. (contact)

PROJECT_TERMS: Address;Advocate;Age;Attention;Behavior Therapy;Biometry;Burn injury;Case Report Form;Child;Chronic Disease;Clinic;Clinical;Clinical Investigator;Clinical Research;clinical research site;Clinical Skills;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Communities;Community Developments;community engagement;community organizations;Community Outreach;community setting;Complement;COVID-19 pandemic;Data;Data Analyses;Databases;design;Development;Elderly;Ensure;Epidemiology;Ethics;Faculty;Failure;Feasibility Studies;Filipino;Food Supplements;Funding;Goals;Hawaii;Health;health disparity;Health Professional;Human Resources;human subject;improved;Indigenous;Infrastructure;innovation;Inpatients;Institution;Institutional Review Boards;Knowledge;Laboratory Technicians;Medical;Medical center;Medical Device;medical schools;medically underserved population;Mentors;Native Hawaiian or Other Pacific Islander;Nursing Research;operation;Outpatients;outreach;Participant;Patient Rights;patient safety;Perinatal;Persons;Pharmacologic Substance;Physicians;Pilot Projects;Play;Procedures;Process;Professional Organizations;programs;psychologic;Reduce health disparities;Regulatory Affairs;Research;Research Design;Research Personnel;Resources;Role;Safety;Science;Scientist;Services;sound;Technology;Time;Translational Research;translational scientist;Trust;Underserved Population;Universities;Vulnerable Populations;wasting;Woman;Work

PROJECT_TITLE: Clinical Research and Regulatory Support Core


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE: The field of metabolomics has mainly been driven by technologies that either completely lose the spatial information of the underlying metabolic processes being studied or require invasive procedures, thus unable to probe metabolism at the most physiologically relevant states. The proposed research aims to develop a research program that will pave a path towards in vivo, noninvasive imaging of tissue metabolomics through development of an unprecedented high-resolution, multinuclear magnetic resonance spectroscopic imaging (MRSI) technology and a novel multimodal biochemical imaging framework that integrates MRSI and mass spectrometry imaging for the first time. If successful, this research will transform metabolomics into a powerful noninvasive and tissue specific tool (from an invasive and nonspatial-specific one) for studying metabolism in living animals and humans.

PI_NAMEs: LAM, FAN  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Animals;Autopsy;Biochemical;Biological;Biological Markers;Biological Process;Biomedical Engineering;biomedical scientist;Cell Nucleus;Complex;complex biological systems;Data;data acquisition;Development;Disease;Disease Management;disease prognosis;Dreams;Generations;Goals;Heterogeneity;high dimensionality;Human;Image;imaging modality;imaging study;Imaging Techniques;Imaging technology;in vivo;in vivo imaging;instrumentation;Machine Learning;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Measures;Metabolic;metabolic abnormality assessment;Metabolism;metabolomics;Molecular;multimodality;NMR Spectroscopy;non-invasive imaging;novel;Nuclear;Nuclear Magnetic Resonance;Physiological;Procedures;programs;Research;Resolution;Sampling;spectroscopic imaging;success;Technology;Time;Tissue imaging;Tissue Sample;Tissues;tool;translation to humans

PROJECT_TITLE: Towards In Vivo Imaging of Tissue Metabolomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


NIH_SPENDING_CATS: Cancer;Immunotherapy

PI_NAMEs: TANSEY, WESLEY  (contact)

PROJECT_TERMS: American;Attention;Bioinformatics;bridge program;cancer immunotherapy;cancer therapy;Cell Communication;Clinical;Communication;Communities;Computational Biology;design;Development;Education and Outreach;Educational Activities;Educational workshop;Funding;Geographic Locations;Goals;Graduate Education;Imagination;immune checkpoint blockade;Immune system;Immunologics;Immunology;Institution;International;Internships;Journals;Knowledge;knowledge base;learning materials;Malignant Neoplasms;medical schools;Memorial Sloan-Kettering Cancer Center;Minority;multidisciplinary;next generation;outreach;programs;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Role;Scientist;Series;STEM student;Students;success;summer research;symposium;System;Systems Biology;Training;Training Activity;treatment response;tumor;tumor progression;Tumor-infiltrating immune cells;undergraduate education;underserved community;Universities;Update;virtual;web site

PROJECT_TITLE: Outreach Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: PE'ER, DANA  (contact)

PROJECT_TERMS: Address;Architecture;Bayesian Analysis;Bayesian Method;Benchmarking;Biological;Cell Communication;cell type;Cells;Communities;Complex;computerized data processing;computerized tools;Computing Methodologies;Data;Data Analyses;data analysis pipeline;data integration;deep learning;denoising;digital;Emerging Technologies;Functional disorder;Generations;Genetic Transcription;genome-wide;genomic data;Goals;Image;Immune;Immune system;improved;intercellular communication;Measurement;Memorial Sloan-Kettering Cancer Center;method development;Methods;Modeling;Molecular;Morphologic artifacts;multiplexed imaging;Neighborhoods;new technology;Phenotype;Play;Population;protein profiling;Proteins;Research;Resolution;Resource Sharing;RNA;Role;single cell genomics;spatial integration;success;System;Systems Biology;Technology;technology development;tissue mapping;Tissues;tool;Transcript;transcriptome;transcriptomics;tumor;tumor microenvironment;tumor-immune system interactions;Work

PROJECT_TITLE: Shared Resource Core: Computational and technology development for spatial expression analysis.


ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative Measuring receptor-ligand interactions on cells is essential in a wide range of biomedical research and clinical applications. However, existing adhesion assays suffer frommany limitations, including bulkiness, low throughput, difficulty in resolving the non-uniform distribution of receptors on single cells, and the inability to measure both tensile and shear forces in cell adhesion. The goal of this proposed project is to develop a novel light-based four-dimensional adhesion frequency assay to overcome these key obstacles and enable a multiplexed and programmable three-dimensional profiling of both shear and tensile affinities of cells and viruses at sub-cellular resolution.

PI_NAMEs: ZHENG, YUEBING  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 2019-nCoV;3-Dimensional;ACE2;Address;Adhesions;Affinity;Anti-Bacterial Agents;Anti-viral Agents;Area;Automation;Bacterial Infections;Benchmarking;Binding;Biological;Biological Assay;Biological Process;Biology;biomaterial compatibility;Biomedical Research;Biometry;Biophotonics;cancer cell;CD8-Positive T-Lymphocytes;Cell Adhesion;cell fixing;cell killing;Cell membrane;Cell surface;Cells;Cellular biology;Cellular Membrane;Clinic;Clinical;clinical application;Communities;Complex;Cytomegalovirus Infections;design;Devices;digital;Endothelium;Environment;Epithelial Cells;Event;experimental study;Four-dimensional;Frequencies;Glycoproteins;Goals;Hematopoietic;Human body;imaging system;Immunity;Immunotherapy;improved;Infection;insight;invention;Kinetics;Lasers;Ligands;Light;Major Histocompatibility Complex;Maps;Measurement;Measures;medical schools;Methods;Microfluidics;microrobot;microsystems;Modality;multimodality;multiplex assay;novel;operation;optical imaging;Optics;pathogen;Peptides;Performance;Pharmaceutical Preparations;Process;Production;prototype;receptor;Recombinants;recruit;Research;Research Personnel;Resolution;Rotation;shear stress;simulation;Site;Solid;Stress;Surface;Surface Plasmon Resonance;System;T-Cell Receptor;T-Lymphocyte;Techniques;Technology;technology research and development;Translations;United States National Institutes of Health;user-friendly;Virus;Virus Diseases

PROJECT_TITLE: Four-dimensional Adhesion Frequency Assay for Full Profiling of Receptor-ligand Interactions on Cells

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Cancer;Liver Disease;Nutrition;Obesity;Prevention;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: The obesity epidemic has led to the increased incidence of fatty liver disease that can lead to hepatocellular carcinoma (HCC), which is the 4th leading cause of cancer deaths in the US. There are no effective treatments for this disease and the molecular pathways that lead to HCC in the context of obesity are not well understood. The studies proposed here will investigate a novel molecular pathway mediated by HAF which protects cells against the stresses associated with fatty liver disease that can lead to HCC, and thus reveal new treatment strategies.

PI_NAMEs: KOH, MEI YEE  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Address;Age;Albumins;Apoptosis;Automobile Driving;Cancer Etiology;Carcinoma;Cell Death;Cell Death Induction;Cells;Cessation of life;Complex;cytokine;Cytoprotection;diagnostic strategy;dietary;Disease;Disease Progression;DNA Damage;Early Diagnosis;effective therapy;Etiology;Fatty Liver;fatty liver disease;Female;Fibrosis;Functional disorder;Genes;Genetic Transcription;Genomic Instability;Goals;HAF deficiency;Hepatitis;Hepatocyte;Heterozygote;Human;Hypoxia;Hypoxia Pathway;In Vitro;in vivo;Incidence;Infiltration;Inflammatory;Inflammatory Response;insight;knock-down;Link;Liver;liver inflammation;liver injury;male;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant Neoplasms;Measures;Mediating;Mediator;Medical;Metabolic;metabolic-associated fatty liver disease;Molecular;Monitor;mortality;mouse model;Mus;neoplastic;Neoplastic liver;new therapeutic target;nonalcoholic steatohepatitis;novel;novel diagnostics;novel therapeutic intervention;Nuclear;Obesity;Obesity Epidemic;Outcome;overexpression;p65;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Phosphorylation;Phosphotransferases;Physiological;Play;potential biomarker;predictive marker;Prevalence;prevent;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Prognostic Marker;Proteins;response;Role;Sampling;screening;Severities;Signal Transduction;Small Interfering RNA;Stress;Testing;therapeutic target;therapy resistant;Time;Tissues;TNF gene;TNFRSF5 gene;Transfection;Transforming Growth Factor beta;treatment response;treatment strategy;Tumor Necrosis Factor-Beta;Tumor Suppressor Proteins;ubiquitin-protein ligase;Viral hepatitis

PROJECT_TITLE: A Role for the Novel HAF-NFkappaB Axis in Driving Obesity-Associated Liver Cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Sexually Transmitted Infections;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Alcohol is the most prevalently used substance among gay and bisexual men (GBM) but the impact of alcohol use and misuse on PrEP adherence is not well understood; therefore, the proposed research uses multiple data collection methodologies to better elucidate how alcohol effects PrEP adherence. The information that will be gained from the study is relevant to public health efforts to eliminate the HIV epidemic in the U.S. and relevant to NIAAA’s research priority to reduce HIV incidence and improve prevention strategies, including consistent use of PrEP, among GBM who drink.

PI_NAMEs: WESTMORELAND, DREW ANNE (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Adherence;Age;AIDS prevention;Alcohol consumption;alcohol effect;alcohol involvement;alcohol measurement;alcohol misuse;alcohol research;alcohol testing;alcohol use disorder;Alcohols;American;Attitude;Back;Belief;Bisexual;Blood;career;career development;Caring;Communication;Complex;condomless anal sex;condoms;contextual factors;Continuity of Patient Care;Dairying;Data;Data Analyses;Data Collection;data collection methodology;Decision Making;Diagnosis;diaries;Dose;drinking;Dryness;Ecological momentary assessment;Educational workshop;emtricitabine;Enrollment;Epidemic;Epidemiologist;Ethnic Origin;experience;FDA approved;follow-up;Formulation;Fumarates;Gays;General Population;Goals;Grant;Growth;Health behavior;high risk;HIV;HIV risk;HIV Seronegativity;HIV Seropositivity;HIV/STD;implementation science;improved;Incidence;Individual;Infection;Intervention;Interview;K-Series Research Career Programs;knowledge base;Link;Literature;meetings;men;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Methods;Monitor;multiple data sources;National Institute on Alcohol Abuse and Alcoholism;Outcome;Participant;participant enrollment;Pathway interactions;Patient Self-Report;Pattern;people of color;Perception;Persons;Pharmaceutical Preparations;pill;Play;Population;pre-exposure prophylaxis;prevent;Prevention Research;Prevention strategy;Principal Investigator;Public Health;Publishing;Qualitative Research;Race;Recommendation;Research;Research Methodology;Research Personnel;Research Priority;Risk;Risk Behaviors;Risk Reduction;Role;Sampling;Schedule;sex;Sex Behavior;Sexual Health;Sexual Partners;sexual risk behavior;sexual risk reduction;skills;social;Specimen;Spottings;substance use;Surveys;Techniques;Tenofovir;tenure track;Testing;Time;timeline;Toxic effect;Training;United States;Unsafe Sex;uptake;Viral;Writing

PROJECT_TITLE: The Impact of Alcohol on PrEP Adherence in Vulnerable Men

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: Project Narrative We develop the multiplexed super-resolution force spectroscopy to investigate the mechanism of ribosome translocation during protein synthesis. We will measure the power strokes from elongation factors and their mutants during ribosome translocation on modified mRNA sequences and in the presence of antibiotics. Our research will provide new model about the ribosome translocation with sub-codon steps and provide potential drug targets for the related diseases.

PI_NAMEs: WANG, YUHONG  (contact);XU, SHOUJUN

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Acoustics;Affect;Amino Acids;Antibiotic Resistance;Antibiotics;base;Binding;Biological Assay;biophysical tools;CAG repeat;Cardiovascular Diseases;Cells;Child;Codon Nucleotides;Congenital Epilepsy;Degenerative Disorder;design;Detection;Disease;disease-causing mutation;DNA Tumor Viruses;Drug Targeting;Elongation Factor;Epilepsy;Exons;Funding;G-Quartets;Generations;Grant;GTP Binding;Guanosine Triphosphate;Health;Homologous Gene;Human;human disease;Huntington Disease;Huntington gene;improved;insight;Intellectual functioning disability;Kinetics;Knowledge;Legal patent;Location;Maintenance;Malignant Neoplasms;Manuscripts;Measurement;Measures;mechanical force;Messenger RNA;Methods;Modeling;Modification;Movement;multiplex detection;Muscle;mutant;Mutation;Neurons;new technology;new therapeutic target;novel;Nucleotides;Outcome;Paper;Peptide Elongation Factor G;Peptides;Phase;Phosphorylation;Phosphotransferases;Play;Positioning Attribute;Power stroke;Process;Protein Biosynthesis;Radiation;Reading Frames;Regulation;Research;Resistance;Resolution;Ribosomal RNA;Ribosomes;RNA;Role;Sampling;Scheme;sensor;Side;Spectrum Analysis;Structure;Techniques;therapeutic target;Time;Transfer RNA;Translational Regulation;Translations;translocase;ultra high resolution;Virus Diseases

PROJECT_TITLE: A novel force spectroscopy to study the ribosome power strokes and frameshifting

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE We propose to utilize the Youth Risk Behavior Survey (YRBS) to assess alcohol use disparities between sexual minority youth (SMY) and heterosexual youth at the intersections of multiple marginalized identities including sex and race/ethnicity, and to determine how these associations impact HIV vulnerability. The team’s pooled dataset, which contains 950,295 youth from local versions of the YRBS, will be extended to include YRBS data collected between 2021 and 2025, providing the opportunity to conduct innovative, intersectional research on the associations between alcohol use, HIV vulnerabilities, and mental health on a national scale and adapt novel methodologies for this purpose. This project builds upon a highly successful prior R01 which facilitated critical health disparities research, interdisciplinary collaboration, and high-impact publication, by strengthening the available sample and leveraging additional modes of complex quantitative inquiry to support innovation in analysis and application of results.

PI_NAMEs: PHILLIPS, GREGORY L. (contact)

PROJECT_TERMS: Address;Adolescence;Adolescent Risk Behavior;Adult;Age;aging population;Alaska Native;Alcohol abuse;alcohol consequences;Alcohol consumption;alcohol risk;Alcohols;American;American Indians;Anxiety;Area;Attenuated;Behavior;behavioral and social science;binge drinking;Bisexual;Categories;Cities;Climate;college;comparative;Complex;County;Critical Pathways;Data;Data Pooling;Data Set;Dependence;Development;Disparity;drug of abuse;Drug usage;Emergency department visit;Ensure;Epidemiology;ethnic minority;Ethnic Origin;experience;Funding;Goals;Health;Health behavior;Health Disparities Research;health disparity;health equity;Heterosexuals;high school;High School Student;HIV;HIV disparities;HIV risk;Individual;individual variation;innovation;interdisciplinary collaboration;Intervention;Investigation;Journals;large datasets;Legal;lens;male;marginalization;Mental Depression;Mental Health;Methodology;Methods;Minority Status;minority stress;multilevel analysis;National Institute on Alcohol Abuse and Alcoholism;Neurocognitive;NIH Office of AIDS Research;non-suicidal self injury;novel;Outcome;outcome disparities;Participant;Pathway interactions;Pattern;Pediatrics;peer;Peer Review;physical conditioning;Policies;Population;Positioning Attribute;Prevalence;psychological distress;Public Health;Publications;Race;racial minority;Reporting;Research;Research Personnel;Research Priority;risk minimization;Role;same-sex marriage;Sample Size;Sampling;School-Age Population;Schools;sex;Sex Behavior;Sex Orientation;Sexual Health;sexual identity;sexual minority;sexual minority youth;Social Change;social science research;social stigma;Statistical Methods;Stigmatization;substance use;success;Suicide;Surveys;Techniques;theories;Time;Time trend;Tobacco use;trend;United States;Unsafe Sex;Vulnerable Populations;Work;young men who have sex with men;Youth

PROJECT_TITLE: Intersectional Approaches to Population-Level Health Research: Role of HIV Risk and Mental Health in Alcohol Use Disparities among Diverse Sexual Minority Youth


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Malaria;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

ORG_CITY: MENANDS

ORG_NAME: WADSWORTH CENTER

PHR: Project Narrative – Public Health Relevance Malaria remains the major mosquito-borne parasitic disease worldwide, and Venezuela and Brazil combined are currently responsible for an estimated 720,000 malaria cases, 75% of all those reported in South America. Our studies will provide the first regional comparison of key understudied ecological mechanisms and landscape genetics directly linked to malaria risk from the primary malaria vectors in endemic hotspots: gold mining settlements in Venezuela and rainforest riverine, mining, and agricultural settlements in Brazil. This field-based study at multiple spatial scales will provide evidence to improve control strategies that maximally impact malaria transmission.

PI_NAMEs: CONN, JAN E (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Affect;Agriculture;Anopheles gambiae;Anopheles Genus;anthropogenesis;Atlases;Automobile Driving;Blood;Brazil;Case Study;Categories;Characteristics;Chromosome Mapping;Collection;Copy Number Polymorphism;Country;Coupled;Coupling;Data;Deforestation;Demography;DNA Resequencing;Ecology;Economic Development;Elements;Evolution;Female;forest;Genes;Genetic;Genetic Drift;Genetic Markers;Genetic Polymorphism;Genetic Variation;Genome;genome sequencing;genome-wide;genomic signature;Genomics;Geographic Locations;Goals;Gold;Habitats;Household;Human;Human Bites;improved;indexing;Individual;insight;Interruption;Intervention;Knowledge;land cover;land use;Latin America;life history;Link;Maintenance;Malaria;malaria transmission;Measurable;Measures;Mining;mosquito-borne;Nature;Nucleotides;Panama;Parasitic Diseases;parity;Pattern;Population;Population Genetics;Population Sizes;Precipitation;pressure;Prevalence;Proliferating;Public Health;public health relevance;Rain;reference genome;regional difference;Reporting;Resistance;Rest;Risk;Risk Factors;Role;Rural;Sampling;Seasons;Signal Transduction;Single Nucleotide Polymorphism;Socioeconomic Factors;socioeconomics;South America;Structure;sugar;Surveys;Temperature;Testing;transmission process;Variant;vector;Vectorial capacity;Venezuela;whole genome

PROJECT_TITLE: Latitudinal Landscape Genomics and Ecology of Anopheles Darlingi

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE This Clinical and Translational Science Award (CTSA) will continue support for the The Ohio State University (OSU) Center for Clinical and Translational Science (CCTS) in partnership with Nationwide Children’s Hospital. Applying a health equity and DEIA lens to everything we do, we will address critical clinical translational roadblocks to provide leadership, education, training, and resources, in collaboration with the CTSA Consortium, to advance today’s discoveries and improve health for all.

PI_NAMEs: GERHARDT, CYNTHIA A;JOHNSON, JULIE A. (contact)

PROGRAM_OFFICER_NAME: CURE, PABLO

PROJECT_TERMS: Address;Adopted;Appalachian Region;Applied Research;career development;Clinical;Clinical and Translational Science Awards;clinical center;Clinical Research;Clinical Sciences;clinical translation;Clinical Trials Informatics System;clinically relevant;Collaborations;college;Communities;community engaged research;complex data;computing resources;cost;COVID-19;Data;data access;Data Science;Data Set;Decision Making;Democracy;demographics;Development;Discipline;Disparity;Dissemination and Implementation;Education;Effectiveness;Ensure;Environment;Equity;Faculty;Foundations;Funding;Grant;Growth;Health;health care delivery;health disparity;health equity;Healthcare;Human;implementation science;improved;Individual;Industry;Infant;Infrastructure;innovation;Institution;Investments;Knowledge;Leadership;Left;lens;Life Cycle Stages;Maternal Mortality;Medical center;member;Methods;multi-site trial;novel strategies;Ohio;opioid epidemic;Outcomes Research;Patients;Pediatric Hospitals;Population;Process;Public Health;Racial injustice;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Design;Research Personnel;Resource Informatics;Resources;response;Rural;Science;skills;social;social health determinants;System;Systems Integration;Thinking;tool;Training;Training and Education;Training Support;translational pipeline;Translational Research;Universities;Validation;Vision;Voice;Work

PROJECT_TITLE: The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve Health


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: American Indian or Alaska Native;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE This proposal seeks to continue the successful holistic University of Utah Native American Research Internship (NARI) program to include summer research experiences in diabetes, obesity, and metabolism, which are major health concerns of the AI/AN population. The NARI-NIDDK program will partner diabetes, obesity and metabolism researchers at the University of Utah with those AI/AN undergraduates who aspire to help understand why AI/AN have been affected so disproportionately. The overarching goal of the NARI-NIDDK program is to increase the diversity of the U.S. biomedical science workforce and reduce health disparities in the AI/AN population by supporting the scientific development of each undergraduate NARI-NIDDK participant.

PI_NAMEs: HOLSTI, MAIJA  (contact);SUMMERS, SCOTT A

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Adult;Affect;African American population;Age;Alaska Native;Alaska Native population;American Indian Population;American Indians;Area;Bachelor's Degree;Basic Science;Biomedical Research;Cardiovascular Diseases;career;Cessation of life;Clinical;Clinical Research;college;Communities;community engagement;Degree Completion;Development;diabetes education;Diabetes Mellitus;Diagnosis;Disease;Drops;Education;effectiveness evaluation;ethnic minority population;experience;Faculty;Family;Family member;Goals;graduate school;Health;health disparity;Healthcare;High Prevalence;higher education;Home;innovation;interest;Internships;Leadership;life span;medical schools;Medicine;member;Mentors;Mentorship;Metabolism;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Native Americans;native elder;Native-Born;Not Hispanic or Latino;Obesity;Outcome;outreach;outreach program;Participant;peer;Persons;poor health outcome;Population;Positioning Attribute;Professional Education;programs;racial minority population;recruit;Reduce health disparities;Reporting;Research;Research Assistant;Research Personnel;Research Project Grants;Risk Factors;Science;Scientist;stem;STEM research;Students;summer internship;summer program;summer research;Talents;Training;Translational Research;tribal Nation;undergraduate student;Underrepresented Minority;underserved community;United States;Universities;Utah;Work

PROJECT_TITLE: Native American Research Internship (NARI) Summer Program in Diabetes, Obesity and Metabolism

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Immunotherapy;Infectious Diseases;Lupus;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: PROJECT NARRATIVE Patients with combined immunodeficiencies (CID), such as partial recombination activating gene (RAG) deficiency, often present with chronic infections and autoimmune diseases, in which B and T cells are dysfunctional, including many B cells that produce antibodies against self. We aim to specifically determine the unique characteristics and fate of these autoantibody-producing B cells and to understand how they go awry in partial RAG deficiency. Accomplishing these aims may help researchers design treatments to correct the tendency of these B cells to produce autoantibodies rather than protective antibodies, and thus alleviate autoimmunity and susceptibility to infections in patients with partial RAG deficiency and other CID.

PI_NAMEs: WALTER, JOLAN ESZTER (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Acceleration;Age;age related;anti-CD20;Antibodies;Antibody Response;Antibody-Producing Cells;Antigens;Apoptosis;Autoantibodies;Autoantigens;Autoimmune;Autoimmune biomarker;Autoimmune Diseases;Autoimmunity;Automobile Driving;autoreactive B cell;autoreactivity;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocyte Subsets;B-Lymphocytes;Cell Count;Cell Lineage;Cell secretion;Cells;Characteristics;Chronic;chronic infection;Clinical;Coculture Techniques;cohort;Common Variable Immunodeficiency;Communicable Diseases;congenital immunodeficiency;Contracts;CTLA4 gene;cytokine;cytopenia;Data;Development;Disease;Etiology;Event;experimental study;Gene Expression;Generations;Genes;Genetic Predisposition to Disease;Genetic Recombination;Germ-Free;Goals;Helper-Inducer T-Lymphocyte;Herpesviridae;Human;Human Herpesvirus 4;Humoral Immunities;Hyperactivity;Immune;Immunity;immunodeficiency;Immunologic Stimulation;Impairment;improved;Individual;Infection;Inflammation;Inflammatory;innovation;Interferon Type II;interleukin-21;International;Intervention;Mediating;Microbe;microbial;Modeling;Molecular;mouse model;Mus;novel;Pathogenesis;Patients;Persons;Phenotype;Play;Population;Predisposition;Production;Proliferating;Receptor Signaling;recombinase;Refractory;Regulatory T-Lymphocyte;Research;Research Personnel;response;Severities;Signal Pathway;Signal Transduction;Site;Stimulus;Surface;Systemic Lupus Erythematosus;T cell therapy;T-Cell Activation;T-Lymphocyte;Testing;therapy design;TLR7 gene;Toll-like receptors;transcription factor;transcriptome;Variant;Virus;Virus Diseases

PROJECT_TITLE: Mechanisms driving extrafollicular polyreactive B cell lineages in partial RAG deficiency

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Complementary and Integrative Health;Dementia;Lymphatic Research;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Sleep Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PI_NAMEs: KELLEY, DOUGLAS H (contact)

PROGRAM_OFFICER_NAME: HORGUSLUOGLU, EMRIN U

PROJECT_TERMS: 3-Dimensional;Address;Alzheimer's Disease;Artificial Intelligence;Biology;Blood Vessels;Brain;Brain imaging;Brain region;Cephalic;Cerebrospinal Fluid;Clinical;Communities;contrast enhanced;Contrast Media;Data;data-driven model;Educational process of instructing;Engineering;Equation;experience;Failure;fluid flow;Future;glymphatic flow;glymphatic function;glymphatic system;Health;high risk;High School Student;Human;Image;imaging modality;improvement on sleep;in vivo;in vivo imaging;Intercellular Fluid;invention;Link;Liquid substance;Magnetic Resonance Imaging;Measurement;Measures;Methods;Modality;Morphologic artifacts;Mus;Nature;neural network;Neurologic;Neurosciences;Noise;novel;outreach;particle;Pathologic;Pathologic Processes;Physics;Postdoctoral Fellow;pressure;Rehabilitation therapy;Research Personnel;Resolution;Science;Series;Sleep;Sorting;spatiotemporal;Speed;Stroke;synthetic data;System;Techniques;Training;Traumatic Brain Injury;two-dimensional;two-photon;Variant;wasting;Work

PROJECT_TITLE: CRCNS: Waste-clearance flows in the brain measured using physics-informed neural network


ORG_CITY: ATLANTA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Liver receptor homolog 1 (LRH-1) is a nuclear hormone receptor that acts as an important regulator of lipid and glucose metabolism and has shown promise as a new therapeutic target for obesity-related metabolic diseases; however, a poor understanding of how ligands regulate LRH-1 has hampered development of modulators. This proposal is centered on improving recently developed high-affinity LRH-1 modulators to support in vivo studies for use in a new humanized LRH-1 mouse model. These tools will enable the study of LRH-1 biology and have therapeutic potential for diseases such as diabetes and fatty liver disease.

PI_NAMEs: CALVERT, JOHN WINTER;ORTLUND, ERIC A (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Address;Adipose tissue;Affinity;Agonist;American;Anti-diabetic Drugs;Atherosclerosis;Award;Behavior;Bile Acids;Binding;Binding Sites;Biological;Biological Assay;Biological Availability;Biology;biophysical properties;Cardiovascular Diseases;Characteristics;Charge;Chemicals;Chemistry;Clinical;comorbidity;CRISPR/Cas technology;design;Development;Diabetes Mellitus;diet-induced obesity;dietary;Disease;Dose;Drug Kinetics;efficacy evaluation;Epidemic;Exposure to;Fatty acid glycerol esters;Fatty Acids;fatty liver disease;Gene Expression Profile;Generations;Glucose;glucose metabolism;glucose tolerance;Health;Homeostasis;Human;humanized mouse;improved;in vivo;innovation;insight;Insulin;Insulin Resistance;insulin sensitivity;Knowledge;Lead;Ligand Binding;Ligands;lipid metabolism;lipidomics;Lipids;lipophilicity;liquid chromatography mass spectrometry;Liver;liver function;Measures;Metabolic;Metabolic Diseases;Metabolic Pathway;Modeling;Modification;Monitor;mortality risk;mouse model;mRNA Expression;Mus;Myocardial Infarction;new therapeutic target;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;NR5A2 gene;Nuclear Hormone Receptors;Nuclear Orphan Receptor;Obese Mice;Obesity;Oral cavity;Overnutrition;Overweight;Pharmacodynamics;Pharmacology;Phospholipids;Plasma;pre-clinical;preclinical study;Proteins;Proteomics;Research;reverse cholesterol transport;Risk;Rodent;Rodent Model;Series;small molecule;Stroke;Structure;Structure-Activity Relationship;success;Surface;Testing;Therapeutic;Therapeutic Agents;Tissues;tool;transcriptome;transcriptome sequencing;United States;Work

PROJECT_TITLE: Targeting the orphan nuclear receptor LRH-1 with small molecules

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Narrative Patients with unresectable hepatocellular carcinoma have poor overall survival. Immunotherapy with PD-L1 and VEGF inhibitor is a recent major advance, however, progression free survival remains short at less than 7 months. We propose to examine the clinical activities and immune effect of a novel combination therapy using radiation followed by intratumor injection of autologous dendritic cells followed by standard of care PD-L1 and VEGF inhibitors.

PI_NAMEs: LIN, YI ;PARK, SEAN S (contact);ROBERTS, LEWIS R

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Antigen Presentation;Autologous Dendritic Cells;bevacizumab;Blood;Cancer Etiology;CD14 gene;CD8-Positive T-Lymphocytes;Cell Death;Cells;Cellular Immunity;checkpoint receptors;Cholangiocarcinoma;Clinical;clinical efficacy;Clonal Expansion;Combination immunotherapy;Combined Modality Therapy;cooperative study;Correlative Study;curative treatments;cytotoxic;Cytotoxic T-Lymphocytes;Dendritic Cells;Disease;Distant;Dose;Dose Limiting;Excision;exhaustion;Galactose Binding Lectin;Image Cytometry;Immune;Immune checkpoint inhibitor;Immunotherapy;improved;improved outcome;in vivo;Inflammatory;inhibitor;Injections;innovation;insight;Interferon Type II;Intervention;Investigation;Liver;Liver neoplasms;liver transplantation;manufacture;Mediating;Methods;monocyte;Morbidity - disease rate;mortality;Multicenter Studies;neoantigens;neoplastic cell;novel;novel therapeutics;Operative Surgical Procedures;partial response;Patient-Focused Outcomes;Patients;PD-1 inhibitors;PDL1 inhibitors;Phase;phase 2 study;Phase II Clinical Trials;Pilot Projects;Primary carcinoma of the liver cells;primary endpoint;Primary Malignant Neoplasm of Liver;programmed cell death ligand 1;programmed cell death protein 1;Progression-Free Survivals;Radiation;Radiation therapy;Recurrent disease;Reporting;resistance mechanism;response;Role;Running;Safety;Serious Adverse Event;Signal Transduction;single-cell RNA sequencing;spatial relationship;Stable Disease;standard of care;Survival Rate;T cell receptor repertoire sequencing;T cell response;T-Lymphocyte;Technology;Testing;Therapeutic;therapeutic development;Toxic effect;transcriptome;treatment center;tumor;Tumor Antigens;Tumor Expansion;Tumor-Derived;Unresectable;Up-Regulation;uptake;Vegf Inhibitor

PROJECT_TITLE: Radiation and dendritic cells to hepatomas to improve immunotherapy response

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Physical Rehabilitation;Rehabilitation

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE  Speech disorders negatively impact communication, reducing the overall quality of life and well-being of individuals with speech disorders. The proposed research is relevant to public health because the project’s findings will form a strong scientific foundation for developing theory-driven, effective, and optimized treatments for speech disorders. Additionally, this project will pave the way for developing more refined and complete theoretical perspectives of speech and speech disorders.

PI_NAMEs: DALIRI, AYOUB  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Adult;Apraxia;Auditory;auditory feedback;Awareness;Behavior;Behavior Therapy;Behavioral;Black race;clinically relevant;Communication;Communication impairment;Communications Media;Computer Models;design;Detection;Development;Disease;effective therapy;Emotional;Ensure;Experimental Models;Feedback;Foundations;Goals;Impairment;improved;Individual;Individual Differences;individual variation;Knowledge;Learning;Maps;Methods;Modeling;Motor;motor control;motor learning;novel;Outcome;Output;Performance;Personal Satisfaction;personalized medicine;Process;process improvement;Production;programs;Protocols documentation;Public Health;Quality of life;Research;response;Sensory;social;sound;Speech;speech accuracy;Speech Disorders;Stuttering;System;Testing;Theoretical model;theories;Training;Treatment Effectiveness;treatment optimization;treatment response;Troglodytinae;Visual;visual feedback

PROJECT_TITLE: Improving speech motor learning processes using augmented behavioral interventions

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: This project will improve deep-learning based CT image formation methods by extracting and exploiting CT specific information that is innate to the deep learning network, so that CT images appear sharper and less noisy. The better images will help doctors make more accurate diagnosis with high confidence.

PI_NAMEs: XU, JINGYAN  (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: abdominal CT;accurate diagnosis;Affect;calcification;Calcium;Cardiac;Cardiac Catheterization Procedures;Clinic;Clinical;clinical application;clinical efficacy;clinical translation;Computer Vision Systems;coronary computed tomography angiography;Data;Data Collection;Daughter;deep learning;deep neural network;design;Detection;Development;Diagnosis;digital;Ensure;Evaluation;Excision;experience;flexibility;follow-up;Future;Image;Image Analysis;image guided;image reconstruction;imaging modality;imaging properties;improved;innovation;interest;Joints;Kidney;Label;Learning;learning network;Lesion;Libraries;Liver;loss of function;Methods;Modeling;Modernization;Mothers;Names;neural network architecture;Noise;Output;Patients;Performance;Photons;Physics;Process;Proliferating;Property;prospective;radiologist;Research;Research Personnel;Resolution;response;Running;Sampling;Signal Transduction;Site;Specific qualifier value;statistics;System;Systems Analysis;Task Performances;Technology;Testing;Time;Training;Validation;Work;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: DL-based CT image formation with characterization and control of resolution and noise

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Women's Health Research

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE We developed a cost-effective, minimally-invasive approach to determine the amount of tumor-derived DNA in blood through shallow (‘ultra low-pass’) whole genome sequencing of cell-free DNA from a single blood sample. In this proposal, we will analytically validate our cell-free DNA assay (UH2 portion) then establish clinical validity and prospectively evaluate performance in metastatic breast cancer through two large tissue collection and two therapeutic clinical trials (UH3 portion). The ultimate goal of this research is to utilize this cell-free DNA genomic biomarker to guide therapy in metastatic breast and other cancers.

PI_NAMEs: ADALSTEINSSON, VIKTOR ;LENNON, NIALL JOHN (contact);STOVER, DANIEL G.

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: Advanced Malignant Neoplasm;androgen independent prostate cancer;Androgen Receptor;antagonist;assay development;Biological Assay;Biopsy;Blood;Blood specimen;Blood Tests;Breast;cancer type;Cell Fraction;cell free DNA;Circulation;Clinical;Collaborations;Collection;computational pipelines;cost effective;Dedications;Detection;Development;DNA;DNA sequencing;Estrogen receptor positive;Genes;genome sequencing;genomic biomarker;Goals;Hemorrhage;improved;ineffective therapies;Infection;inhibitor;innovation;Institution;Knowledge;Libraries;liquid biopsy;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;MEKs;Metastatic breast cancer;minimally invasive;Multiple Myeloma;Mutate;Mutation;Pain;patient oriented;patient response;Patients;pembrolizumab;Performance;Plasma;Ploidies;Process;Prognosis;prospective;Proto-Oncogene Proteins c-akt;Protocols documentation;Publications;Quality of life;Reproducibility;Research;Research Personnel;Risk;Role;Running;Sampling;Sensitivity and Specificity;Specimen;success;survival outcome;Testing;Therapeutic;Therapeutic Clinical Trial;Therapeutic Trials;therapy outcome;Time;time interval;Tissue Banks;treatment response;triple-negative invasive breast carcinoma;Tube;tumor;tumor DNA;Tumor-Derived;Validation;whole genome;Work

PROJECT_TITLE: Assay Validation of Cell-Free DNA Shallow Whole Genome Sequencing To Determine 'Tumor Fraction' in Advanced Cancers


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative  This project aims to develop new imaging agents that can efficiently detect parathyroid glands preoperatively, and be used intraoperatively to guide exploration. It is expected that PET signal will introduce high sensitivity for parathyroid detection, and NIRF signal will facilitate subsequent gland localization during surgery. The success of this application will greatly benefit the management of patients with primary hyperparathyroidism.

PI_NAMEs: KIM, LAWRENCE THOMAS;WU, ZHANHONG  (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Address;adenoma;Affect;Area;Calcium;Calcium-Sensing Receptors;Cells;cinacalcet;Circulation;Clinical;Data;design;Detection;Development;Disease;Dissection;Dyes;Ensure;Evaluation;Excision;extracellular;Fluorescence;fluorescence-guided surgery;Fluorescent Dyes;fluorophore;G-Protein-Coupled Receptors;Gland;Goals;Human;Hydrogen Bonding;Hyperparathyroidism;Image;Image-Guided Surgery;imaging agent;imaging modality;Imaging Techniques;improved;innovation;Interdisciplinary Study;interest;Isotopes;Kidney;Label;Lasers;Lead;Ligands;Location;lymph nodes;Membrane;Methods;Modality;Modeling;Morbidity - disease rate;Multiple Abnormalities;Neck;Nodule;nonhuman primate;Normal tissue morphology;novel;novel imaging technique;Operative Surgical Procedures;Optics;Parathyroid Adenoma;Parathyroid gland;Patients;Penetration;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Play;Positron-Emission Tomography;prevent;Radio;Rattus;Reaction;receptor;Research;Rodent Model;Role;Sestamibi Scan;Signal Transduction;small molecule;Stains;success;targeted agent;Technology;Thyroid Gland;Tissues;Tracer;Transplantation;ultrasound;United States;X-Ray Computed Tomography

PROJECT_TITLE: The development of novel PET/NIRF agents for hyperparathyroidism management

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Primary Health Care;Rehabilitation;Rural Health

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE There is substantial evidence that conducting multifactorial fall risk assessments and developing personalized prevention plans in primary care settings can reduce falls, but many barriers exist to integrating this evidence into practice. The US Preventive Service Task Force recommends fall prevention exercises for community- dwelling adults who are at increased risk for falls, however less than half of older persons report discussing their falls with their primary care providers (PCPs). The goal of this project is to develop, test, and evaluate shareable, standards-based fall prevention clinical decision support, eSTEPS (electronic Strategies for Tailored Exercise to Prevent FallS) that can used by primary care providers to facilitate personalized activity and exercise prescriptions and reduce falls in at risk older adults.

PI_NAMEs: DYKES, PATRICIA C (contact);LATHAM, NANCY K

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Address;Adopted;Adult;Algorithms;American;Artificial Intelligence;behavior change;Caring;clinical decision support;Clinical Decision Support Systems;clinical practice;Clinical Trials;clinically actionable;cohort;Communities;cost;Data;Decision Making;design;Development;Disparity;disparity reduction;effective intervention;effectiveness evaluation;efficacy testing;Elderly;Electronic Health Record;Electronics;Emergency department visit;Ensure;evidence base;evidence based guidelines;Exercise;exercise prescription;exercise program;Exercise Test;experience;fall injury;Fall prevention;fall risk;falls;Focus Groups;Frequencies;Goals;Guidelines;Health;Health system;Healthcare;high risk;Home;Hour;implementation protocol;improved;individualized prevention;Intervention;Learning;Length of Stay;Machine Learning;machine learning method;Meta-Analysis;Monitor;neighborhood safety;older adult;older patient;Older Population;patient engagement;patient oriented;patient portal;Patient Preferences;Patients;Persons;Populations at Risk;predictive modeling;Prevention Guidelines;Prevention program;Primary Care;primary care clinic;primary care practice;primary care provider;primary care setting;programs;Randomized, Controlled Trials;Recommendation;Reporting;Research;Risk;Risk Assessment;Risk Reduction;Rural;rural area;Safety;screening;Screening procedure;smartphone application;Technology;Testing;treatment as usual;United States;United States Preventative Services Task Force;usability;Visit;wellness visit

PROJECT_TITLE: electronic Strategies for Tailored Exercise to Prevent FallS (eSTEPS).


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Emphysema;HIV/AIDS;Infectious Diseases;Lung

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Emphysema is a common serious co-morbidity in people living with HIV (PLWH). We will study if doxycycline slows its progression in PLWH (current or former smokers) by measuring diffusing capacity (how well oxygen transfers from air into blood) and quantifying computed tomography (CT) scans of the lungs. We will evaluate if doxycycline improves health status with patient-oriented surveys and functional status with 6 minute walk tests in a multi-center, randomized, placebo-controlled trial.

PI_NAMEs: GLESBY, MARSHALL J;KANER, ROBERT J (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Acceleration;Address;Adult;Age of Onset;Air;Alveolar Macrophages;Antibiotics;antiretroviral therapy;arm;barometric pressure;Biological;Blood;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Carboxyhemoglobin;Cause of Death;Chronic Obstructive Pulmonary Disease;Clinical;clinical care;clinical research site;Clinical stratification;comorbidity;comparison control;Conduct Clinical Trials;Data;Data Coordinating Center;density;Development;Diffusion;Disease;Disease Progression;Double-Blind Method;double-blind placebo controlled trial;Doxycycline;eligible participant;Enrollment;epidemiologic data;experience;FDA approved;former smoker;functional status;Funding;Gelatinase A;Gelatinase B;Gene Expression;General Population;Generic Drugs;Health Status;Hemoglobin;High Prevalence;HIV;HIV Infections;HIV Seronegativity;improved;Incidence;Individual;innovation;Interdisciplinary Study;interest;Intervention;Lung;lung imaging;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Measures;Metalloproteinase Gene;National Heart, Lung, and Blood Institute;Natural History;Oral;Organism;Oxygen;Participant;Pathogenesis;patient oriented;patient population;Performance;Persons;Pharmacy facility;Phase;Phase II Clinical Trials;Pilot Projects;Placebo Control;Placebos;Population;Prevalence;prevent;primary endpoint;Proteins;Pulmonary Emphysema;pulmonary function;Quality of life;radiological imaging;Randomized;randomized placebo controlled trial;Reading;Records;Reporting;Resistance;respiratory;Safety;safety testing;Sampling;Side;Site;Smoke;Smoking Status;success;Surveys;targeted treatment;Testing;Tissues;Training;transcriptome sequencing;treatment duration;trend;Walking;X-Ray Computed Tomography

PROJECT_TITLE: 1/2 Doxycycline for Emphysema in People Living with HIV: The DEPTH Trial

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(JA)]


ORG_NAME: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

PHR: PROJECT NARRATIVE Polyamines are small organic cations that are found in all living organisms. Polyamine levels are dysregulated in multiple diseases, including cancer, but their precise molecular functions are not understood. We will develop and apply new technologies to understand the role of polyamines in cell function and disease.

PI_NAMEs: JAIN, ANKUR  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Affect;Amines;Autophagocytosis;Biochemical;biological adaptation to stress;Biological Assay;Cations;cell growth;Cell Physiology;Cell Survival;Cells;Disease;DNA;DNA Sequence Alteration;Genetic Transcription;Health;Homeostasis;interest;Knowledge;Learning Disabilities;Link;Malignant Neoplasms;Mammalian Cell;Measures;Metabolic Pathway;Metabolism;Methods;Molecular;new technology;Organism;Parkinson Disease;Pathway interactions;pharmacologic;Polyamines;Proteins;Risk Factors;RNA;Role;Snyder-Robinson syndrome;stem;Structure;Technology;therapeutic target;Translations;uptake;Work

PROJECT_TITLE: Elucidating the molecular and cellular functions of polyamines


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

PHR: PROJECT NARRATIVE Smoking accounts for 8 out of 10 COPD-related deaths in the US. The FDA continues its efforts to strengthen tobacco control. There is a lack of evidence about the long-term effects of tobacco regulations on respiratory chronic diseases. This project will use a natural history disease microsimulation model to estimate the impact of two FDA cigarette-oriented regulations on the US COPD burden.

PI_NAMEs: SANCHEZ-ROMERO, LUZ MARIA (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Advertisements;Area;Award;Behavior;Behavioral;Biologic Characteristic;burden of illness;Cancer Intervention and Surveillance Modeling Network;career;Cessation of life;Characteristics;Chronic lung disease;Chronic Obstructive Airway Disease;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;Cigarette;cigarette smoking;Clinical;cohort;Cohort Studies;Collaborations;Complex;Data;design;Development;Disease;disease model;disease natural history;disorder risk;Economic Burden;Electronic Nicotine Delivery Systems;Environment;Epidemiology;experience;flexibility;Functional disorder;Future;Genus Mentha;Goals;Grant;Health;health economics;health warning;Incidence;Individual;Institution;Intervention;Knowledge;Long-Term Effects;Lung;Lung Diseases;Malignant neoplasm of lung;Malignant Neoplasms;markov model;Medical Care Costs;Menthol;Mentors;Michigan;model development;Modeling;models and simulation;Morbidity - disease rate;mortality;Natural History;neoplasm resource;non-cigarette tobacco product;novel;Obstruction;Outcome;Policies;Policy Maker;Population;Prevalence;prevent;Primary Prevention;productivity loss;Public Health;public policy on tobacco;pulmonary function;pulmonary function decline;Race;Recording of previous events;Regulation;Research;Research Activity;Research Personnel;Research Project Grants;Resources;respiratory;Respiratory Disease;respiratory health;Risk Factors;Science;screening;Severities;simulation;skill acquisition;Smoking;Smoking Behavior;smoking exposure;Smoking History;Smoking Status;sociodemographics;System;Technical Expertise;Thinking;Tobacco;tobacco control;tobacco products;tobacco regulation;tobacco regulatory science;tool;Training;Training Activity;Translations;trend;tumor progression;United States National Institutes of Health;Universities;Update

PROJECT_TITLE: Modeling the impact of tobacco regulations on US future trends of Chronic Obstructive Pulmonary Disease.


NIH_SPENDING_CATS: Cancer;Clinical Research;Estrogen;Genetics;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: CORAL GABLES

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: NARRATIVE Prostate cancer resistance to medical castration develops more rapidly in men who inherit the adrenal-permissive germline gain-of-function in the steroidogenic enzyme HSD3B1 we discovered in a previous project period. This proposal will determine whether the adrenal-permissive HSD3B1(1245C) allele is a predictive biomarker that enables treatment selection for upfront treatment and whether the adverse biology is directly reversible by enzyme inhibition. We anticipate that this work is likely to change the standard of care for patients with prostate cancer.

PI_NAMEs: SHARIFI, NIMA  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: abiraterone;Ablation;Adrenal Glands;advanced prostate cancer;Adverse effects;Alleles;androgen biosynthesis;androgen deprivation therapy;androgen independent prostate cancer;Androgens;Aromatase;Automobile Driving;Award;base;Bile Acids;Biological Markers;Biology;BMX gene;Cancer Etiology;Castrate sensitive prostate cancer;Castration;Cell Line;Cessation of life;Clinical;Clinical Trials;clinically significant;Collaborations;Data;dehydroepiandrosterone;design;Disease;DNA;efficacy evaluation;Enrollment;Enzyme Inhibition;Enzymes;Estrogen receptor positive;FDA approved;gain of function;Genetic;genetic variant;Genotype;Germ Lines;Germ-Line Mutation;Gonadal Steroid Hormones;Hepatic;Hepatocyte;hormone therapy;Human;Hydroxysteroid Dehydrogenases;improved;in vivo;individual patient;Inherited;innovation;Institution;ketogenesis;Ketone Bodies;Link;liver metabolism;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Castration;men;Metabolic;Metabolism;Modeling;Molecular;molecular marker;Natural regeneration;Nonmetastatic;novel;Oncology;Outcome;Patient Care;Patient Selection;Patients;permissiveness;Pharmaceutical Preparations;pharmacologic;Phase II Clinical Trials;Phosphorylation;Phosphotransferases;Physiology;Postmenopause;predictive marker;Prior Therapy;Process;Prostate Cancer therapy;Reproducibility;Research Personnel;Resistance;Role;Sampling;Selection for Treatments;Serum;Signal Transduction;standard of care;Stanolone;steroid metabolism;Steroids;Testing;Therapeutic;treatment choice;tumor;Tumor Biology;tumor growth;Variant;Work

PROJECT_TITLE: Elucidating a novel molecular biomarker for castration-resistant prostate cancer

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Antibodies blocking the CD47/SIRPα axis are a promising strategy in cancer immunotherapy with a rapid developing field in recent years. Understanding the contribution of the antibody Fc domain to the antitumor activity of anti-CD47/SIRP α antibodies remains an outstanding question in the field, as there is no consensus on the ideal Fc format to maximize the activity of these agents. The proposed research will inform the development of Fc-optimized anti-CD47/SIRPα antibodies, prevent antibody-mediated toxicities and guide optimal combination strategies, which could be applicable to a wide range of malignancies.

PI_NAMEs: OSORIO, JUAN C (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Anti-CD47;anti-PD-1;Antibodies;antitumor effect;Antitumor Response;Binding;Biological Assay;Blocking Antibodies;cancer cell;cancer immunotherapy;cancer therapy;cancer type;career;career development;CD47 gene;CD47-SIRPα;CD47-SIRPα blockade;CD8-Positive T-Lymphocytes;Cell Surface Receptors;Cells;Classification;Clinic;Clinical;clinical training;Clinical Trials;Consensus;Cytoprotection;Data;Dendritic Cells;Development;Development Plans;early phase clinical trial;Eating;Effector Cell;efficacy testing;Engineering;Ensure;Environment;Epidermal Growth Factor Receptor;experience;Fab Immunoglobulins;Fc Receptor;Fc(alpha) receptor;Flow Cytometry;Foundations;Funding;Future;Goals;Grant;Human;human tissue;humanized mouse;Immune;immune cell infiltrate;immune checkpoint;Immune Targeting;Immunocompetent;Immunocompromised Host;Immunoglobulin Fragments;Immunology;Immunotherapy;Infiltration;Institution;International;Investigation;Laboratories;Laboratory Research;Lead;Macrophage;Malignant Neoplasms;Mediating;Medical Oncology;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;Minority;Modeling;Monoclonal Antibodies;mouse model;Mus;Myelogenous;Myeloid Cells;neoplastic cell;neutrophil;novel;Outcome;overexpression;Pathway interactions;Patients;Phagocytes;Phagocytosis;Phenotype;Physicians;preclinical study;prevent;Prognosis;PTPNS1 gene;Qualifying;rational design;receptor;recruit;Research;Research Project Grants;research study;response;Role;Scientist;Signal Transduction;skills;Specimen;System;T cell response;T-Cell Activation;T-Lymphocyte Subsets;Testing;Therapeutic;Toxic effect;Toxicity Tests;Training;Treatment Efficacy;tumor;Tumor Antigens;Tumor Biology;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;Tumor-infiltrating immune cells;Universities;Variant

PROJECT_TITLE: Role of Fc Receptors in the Therapeutic Activity of Antibodies Targeting the CD47-SIRP-alpha axis

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Clinical Research;Immunotherapy;Precision Medicine;Women's Health Research

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Significant progress in cancer outcome may be achieved through data-driven personalized treatment selection for each patient. EMPIRI’s novel, patent-pending, 3D tumor culture method (E-slices) can accurately predict individual patient’s tumor response to chemo, targeted, and immunotherapies in a clinically actionable time frame. This R01 application will validate the clinical utility of E-slices for TNBC patient care.

PI_NAMEs: GALLUP, DAVID ;UENO, NAOTO T.;YUN, KYUSON  (contact)

PROJECT_TERMS: 3-Dimensional;Adjuvant Chemotherapy;Adriamycin PFS;anti-cancer research;anti-PD-L1;anti-PD-L1 therapy;Architecture;Biological Assay;Biotechnology;Breast Cancer Patient;Breast Cancer Treatment;Businesses;cancer care;Cancer Center;cancer diagnosis;Cancer Diagnostics;Cancer Patient;Carboplatin;Cells;Cessation of life;Characteristics;Chemicals;chemotherapy;Clinical;clinical care;Clinical Data;clinical practice;Clinical Research;clinical translation;Clinical Trials;clinically actionable;cost;Cyclophosphamide;Data;design;diagnostic assay;Diagnostic tests;Doxorubicin;drug sensitivity;Engineering;Evaluation;evidence base;genomic profiles;Genomics;Goals;Immuno-Chemotherapy;Immunotherapy;improved;in vivo;Individual;individual patient;Industrialization;Institution;invention;Legal patent;Licensing;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mechanics;metastatic colorectal;Methodist Church;Methods;Modeling;Molecular Profiling;mouse model;Mutation;Neoadjuvant Therapy;novel;Oncology;Organoids;Outcome;Paclitaxel;Patient Care;patient derived xenograft model;patient response;Patient-derived xenograft models of breast cancer;Patients;pembrolizumab;personalized care;personalized medicine;Pharmaceutical Preparations;Physicians;precision drugs;precision medicine;product development;prospective;Prospective Studies;Reagent;Reporting;Research;Research Institute;resistance mechanism;Resolution;responders and non-responders;response;Retrospective Studies;Scientist;Selection for Treatments;Serum;single cell genomics;Slice;Solid;Solid Neoplasm;standard of care;System;T-Cell Activation;targeted treatment;taxane;Testing;three dimensional cell culture;Time;tissue culture;Tissues;Translating;treatment response;treatment strategy;triple-negative invasive breast carcinoma;tumor;Tumor Biology;tumor immunology;tumor microenvironment;Tumor Tissue;Validation

PROJECT_TITLE: Validation of a novel 3D culture platform for TNBC treatment selection


ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Perineuronal nets (PNNs) are condensed extracellular matrix around a subset of neurons, which play important roles in the regulation of energy and/or glucose homeostasis. Our pilot observations indicate that 17β-estradiol (E2) can increase PNNs in a brain region called posterodorsal medial amygdala (MePD) in both male and female mice, and PNNs in the MePD enmesh GABA neurons and regulate feeding, body weight and glucose balance. We will follow up these findings to test whether E2 induces PNNs to facilitate GABA neurons in the MePD to prevent obesity and metabolic dysregulation.

PI_NAMEs: WANG, CHUNMEI  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: addiction;Adult;adult obesity;Age;Alzheimer's Disease;American;Amygdaloid structure;Appetite Stimulants;behavioral response;Biology;Bipolar Disorder;Blood Glucose;blood glucose regulation;Body Weight;Brain;Brain region;Buffers;Cells;Cellular Structures;Centers for Disease Control and Prevention (U.S.);Chemical Models;Child;Chronic;combat;comorbidity;Digestion;Disease;Dorsal;effective therapy;Electrons;Equilibrium;ESR1 gene;Estradiol;Estrogens;Etiology;Extracellular Matrix;Fatty acid glycerol esters;feeding;Female;follow-up;gain of function;gamma-Aminobutyric Acid;Genetic;genetic approach;Genetic Models;global health;Glucose;Glucose Intolerance;Glycosaminoglycans;Health;High Fat Diet;Homeostasis;hormonal signals;Hyaluronan;Hyperglycemia;Hyperinsulinism;Hyperphagia;Hypothalamic structure;improved;In Situ;insulin sensitivity;Ions;loss of function;male;Medial;Mediating;Metabolic;Metabolic syndrome;Metabolism;Modeling;Molecular;Molecular Conformation;mouse model;Mus;neural;neural circuit;Neurobiology;Neuroglia;Neurons;Neurosecretory Systems;Nutritional status;Obesity;obesity prevention;Overweight;pandemic disease;paracrine;Pattern;Play;Population;Prevalence;prevent;Regulation;Reporting;Role;Schizophrenia;sex;Signal Transduction;Structure;Structure of nucleus infundibularis hypothalami;Synapses;Synaptic plasticity;targeted treatment;Testing;Therapeutic Intervention;Tomogram;Visualization;Weight;Weight Gain

PROJECT_TITLE: ESTROGEN-INDUCIBLE PNNS ENHANCE EXCITATORY SYNAPTIC STRENGTH ONTO GABA NEURONS IN THE MEPD TO PREVENT OBESITY AND METABOLIC DYSREGULATION

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ORG_CITY: RICHLAND

ORG_NAME: BATTELLE PACIFIC NORTHWEST LABORATORIES

PHR: NARRATIVE Heterogeneity is inherent in cellular processes. In disease evolution (e.g., cancer) there is extensive genetic and phenotypic diversity between tumors (intertumour heterogeneity) and within individual tumors (intratumour heterogeneity). However, there is an unmet technical challenge for comprehensive proteomic characterization of tumor heterogeneity. We aim to develop a new proteomics technology for enabling routine, rapid, accurate comprehensive characterization of the diverse heterogeneity of tumor cells to meet current biomedical needs.

PI_NAMEs: SHI, TUJIN  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Acceleration;Address;Adsorption;Amino Acids;Antibodies;Biological;Biology;Biomedical Research;Biopsy;Calibration;Cancer Biology;Carrier Proteins;Cell Culture Techniques;Cell Line;Cell Physiology;Cells;Clinical;Collection;Complex;cost;Coupled;Detection;detection sensitivity;Devices;Disease;Epidermal Growth Factor Receptor;Evolution;experience;Genetic;Genomic Instability;Genomics;Genotype;Goals;Heterogeneity;Human;Immunoassay;improved;Individual;Inductively Coupled Plasma Mass Spectrometry;insight;ion mobility;ion source;ionization;Ions;Label;Lanthanoid Series Elements;Liquid Chromatography;liquid chromatography mass spectrometry;Malignant Neoplasms;Mammalian Cell;MAP Kinase Gene;Mass Spectrum Analysis;Measurement;Messenger RNA;Methods;minimally invasive;Movement;multiple omics;nanoelectrospray;neoplastic cell;Pathway interactions;Peptides;Performance;Phenotype;PIK3CG gene;precision medicine;Preparation;pressure;Proteins;Proteome;Proteomics;Recovery;Research;Resolution;Sampling;Sensitivity and Specificity;Signal Pathway;single cell analysis;single cell technology;Source;Specificity;Specimen;Stable Isotope Labeling;Structure;Surface;surfactant;System;Techniques;Technology;technology development;time of flight mass spectrometry;tool;transcriptome;transcriptomics;tumor;tumor heterogeneity;Variant;whole genome

PROJECT_TITLE: Targeted proteomics technology for accurate quantitative single-cell proteomics