NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Mood and anxiety disorders are frequently associated with aberrant communication between limbic and cognitive neural networks, which may trigger emotional dysregulation. We propose to study small subregions of limbic structures such as the hippocampus and amygdala, using combined structural and functional connectomic analysis and determine how they relate to core symptoms of mood and anxiety disorders. A better understanding of limbic connectomic impairments, and how network organization elements capture differences and commonalities across individuals with mood and anxiety disorders, may provide improved diagnostics and inform more effective treatment strategies.

PI_NAMEs: JACOB, YAEL  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Agreement;Amygdaloid structure;Anatomy;Anxiety;Anxiety Disorders;anxiety symptoms;Architecture;Award;Biological Markers;Brain;Brain imaging;Brain Mapping;Brain region;Classification;Clinical;Cognitive;cognitive system;Communication;Complex;connectome;Data Set;Dependence;depressive symptoms;design;Development;Diagnostic;diagnostic strategy;Diffusion Magnetic Resonance Imaging;Dimensions;Disease;effective therapy;Elements;emotion dysregulation;emotion regulation;Evaluation;experience;Functional Magnetic Resonance Imaging;Generalized Anxiety Disorder;Goals;Grain;graph theory;Hippocampus;Human;Impairment;improved;Individual;Information Networks;K-Series Research Career Programs;Light;Link;Literature;machine learning algorithm;Magnetic Resonance Imaging;Major Depressive Disorder;Maps;Mathematics;Measurement;Measures;Mental Depression;Mental disorders;Methods;Modification;Mood Disorders;mood symptom;multimodal learning;multimodality;Network-based;neural;neural network;neuroimaging;neuromechanism;neuropsychiatry;Noise;novel;Pathway Analysis;Patients;Pattern;programs;Protocols documentation;Research;Resolution;Role;Science;Selection for Treatments;Signal Transduction;skill acquisition;skills;Structure;Symptoms;System;Testing;theories;Time;tool;Training;Translational Research;treatment strategy;ultra high resolution;white matter;Work

PROJECT_TITLE: Multidimensional brain connectome features of depression and anxiety

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Nerve damage and dysfunction have been related to fracture risk and bone health in diverse clinical conditions. Identification and characterization of novel neuroskeletal regulatory pathways has high potential to inform strategies for preventive and regenerative medicine, including treatment of reduced bone mass and strength.

PI_NAMEs: SCHELLER, ERICA LYNN (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: ACTL6B gene;Adolescence;afferent nerve;Anorexia;axonal degeneration;Biosensor;bone;bone cell;Bone Diseases;bone fragility;Bone Growth;bone health;bone mass;bone strength;chemotherapy;Childhood;Chronic;Clinical;Clinical Management;conditional knockout;Custom;Data;Diabetes Mellitus;diabetic;Diabetic mouse;Disease;Enzymes;fracture risk;Functional disorder;Future;Goals;Health;healthy aging;High Fat Diet;Homeostasis;Impairment;in vivo;Inflammation;inhibitor;Injury;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;Knock-out;knockout animal;Knockout Mice;life span;Link;loss of function;MAP Kinase Gene;Mediating;Mediator;Metabolic;Metabolic Diseases;Molecular;mouse model;Multiple Sclerosis;N-terminal;NAD+ Nucleosidase;Natural regeneration;Nerve;nerve damage;Nervous System;neural;Neurodegenerative Disorders;Neurons;Neuropathy;Neurophysiology - biologic function;neuroregulation;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Osteogenesis;Outcome;Oxidative Stress;Pathway interactions;Peripheral;Peripheral Nervous System Diseases;Prevalence;prevent;Prevention;Prevention strategy;Preventive Medicine;Proteins;Regenerative Medicine;Regulation;Regulatory Pathway;Resistance;response;response to injury;Role;sarcopenia;Sensory;Signal Transduction;skeletal;skeletal disorder;Spinal cord injury;Sterility;System;Testing;Therapeutic Intervention;Time;tool;treatment strategy;type I and type II diabetes;Virus;Work

PROJECT_TITLE: Sarm1 and neural regulation of bone

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Estrogen;Liver Disease;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE: The liver exhibits significant sexual dimorphism and spatial heterogeneity within the liver lobule in physiological function and disease manifestation. We show that sexual dimorphism in the liver is spatially zonated due to coordinated interaction between local zonation signals including Wnts and systemic sexual dimorphism signals including growth hormone. We propose studies to characterize zonated sexual dimorphism in the liver, determine the mechanisms that drive it, and test whether it controls sex differences in liver response to non- alcoholic fatty liver disease

PI_NAMEs: WANG, BRUCE MAO ZHENG (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acute;Adult;Affect;age difference;aged;Biological;Cells;Disease;Disease Outcome;Disease Progression;Disease susceptibility;Disparity;Estrogens;Exhibits;fatty liver disease;Gene Expression;Genes;Hepatocyte;Heterogeneity;hormonal signals;human disease;improved;Libido;Liver;Liver diseases;liver function;liver injury;Lobular;Lobule;Mediating;men;Menopause;Metabolic;Modeling;Mus;non-alcoholic fatty liver disease;notch protein;Organ;Outcome;Pathology;Pattern;Physiological;Physiology;Population;Predisposition;prepuberty;reproductive;response;response to injury;Role;Severities;sex;Sex Differences;sexual dimorphism;Signal Transduction;single-cell RNA sequencing;Somatotropin;STAT5B gene;Testing;transcriptomics;Variant;WNT Signaling Pathway;Woman

PROJECT_TITLE: Characterizing zonated hepatocyte sexual dimorphism and its role in fatty liver disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Pediatric;Prevention;Rehabilitation

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: Project Narrative (Relevance) Hearing loss, including deafness, poses obstacles to children's language development and social relationships. This project employs innovative, longitudinal modeling of objectively measured naturalistic behavior to investigate young children's vocal interactions in preschool, and the influence of those interactions on their language development. The project will indicate whether understudied processes of peer- and teacher-influenced language development differ between children with hearing loss and their typically hearing preschool peers over months and years. These efforts will pave the way for classroom-based interventions to enhance the language development of children with hearing loss and other children with language delays.

PI_NAMEs: MESSINGER, DANIEL S (contact);PERRY, LYNN K

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 2 year old;3 year old;4 year old;Affect;Age;Age Months;automated analysis;Behavior;Behavioral;Biological Assay;biological sex;Child;Child Development;Child Language;Cochlear implant procedure;Cochlear Implants;cohort;Competence;Complex;Computer Models;cost;Data;data de-identification;deafness;design;Development;Developmental Process;Early Intervention;Enrollment;Exposure to;Fertile Period;Growth;Hearing;Hearing Aids;hearing impairment;Impairment;improved;indexing;Individual;Individual Differences;innovation;Intervention;Language;Language Delays;Language Development;Life;Location;Measurement;Measures;Mediating;Modeling;Movement;multilevel analysis;Nursery Schools;Oral;Participant;Pattern;peer;Physics;Positioning Attribute;Process;Quality of life;Reproducibility;Role;Sampling;scaffold;Schools;Severities;social;social contact;Social Development;Social Interaction;social relationships;societal costs;Socioeconomic Status;Speech;Speech Development;Standardization;Statistical Models;teacher;temporal measurement;Testing;Time;tool;Veins;vocalization

PROJECT_TITLE: Language Development and Social Interaction in Children with Hearing Loss

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Hearing Loss;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative The auditory midbrain (inferior colliculus) is an important auditory integration center whose dysfunction has been associated with a large number of central hearing impairments. Proposed research will increase our understanding of the organization, physiology, and development of local synaptic networks in the inferior colliculus and explore the role of these networks in generating impaired sound processing. Results from this research will help to fill an important knowledge gap about the neuronal circuits that underlie auditory processing and will help to better understand the cause of perceptual hearing impairments that can result from anomalous hearing experiences during childhood including those resulting from otitis media with effusion.

PI_NAMEs: KANDLER, KARL  (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Address;Affect;Auditory;auditory pathway;auditory processing;awake;Axon;Cell Nucleus;Cell Shape;cell type;Cells;Cellular Morphology;Characteristics;Child;Childhood;Chronic;Communication;Conductive hearing loss;Development;developmental plasticity;Exhibits;experience;Exposure to;Functional disorder;Generations;Glutamates;Hearing;hearing impairment;Hyperacusis;Impairment;In Vitro;in vivo;Inferior Colliculus;insight;Knowledge;Lasers;Location;Maps;Midbrain structure;Morphology;Mus;neural circuit;neuronal circuitry;Neurons;Neurotransmitter Receptor;Noise;novel;optogenetics;Otitis Media with Effusion;patch clamp;Pattern;Physiologic pulse;Physiological;Physiology;Play;preference;presynaptic;Probability;Process;Property;Recording of previous events;Research;response;Role;Scanning;Shapes;Slice;sound;Sound Localization;spatiotemporal;Speech;Speech Perception;stellate cell;Stimulus;Synapses;Synaptic plasticity;Testing;Tinnitus;Whole-Cell Recordings

PROJECT_TITLE: Development of the intrinsic synaptic circuits of the inferior colliculus

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: NEW HAVEN

ORG_NAME: CONNECTICUT AGRICULTURAL EXPERIMENT STA

ORG_STATE: CT

PHR: Project Narrative How sensory systems adapt to allow an organism to exploit a new environment is one of the most ancient and fundamental problems in biology. This project is designed to elucidate the molecular underpinnings of chemosensory adaptations. This project may provide new molecular targets and new eco-friendly strategies to control insects, including vectors of human diseases.

PI_NAMEs: DWECK, HANY  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Adaptive Behaviors;Address;Affect;Agriculture;Alleles;Behavior;Behavioral;Binding Sites;Biological;Biological Models;Biology;Candidate Disease Gene;Cells;Central Nervous System;Chemicals;Code;Complex;CRISPR/Cas technology;Cues;Cytochrome P450;design;Drosophila genus;economic implication;egg;Electrophysiology (science);Enhancers;Environment;Enzymes;Evolution;Experimental Designs;experimental study;Family;Fermentation;fly;Friends;Fruit;Gene Combinations;Genes;Genetic;Genetic Models;Glutathione S-Transferase;Goals;human disease;In Situ Hybridization;Individual;Insect Control;Insect Vectors;Insecta;Knowledge;Label;Leg;Logic;loss of function mutation;Modeling;Molecular;Molecular Target;mutant;neuronal patterning;Organism;Oviposition;Pattern;Perception;Persons;Plants;preference;receptor;response;Reverse Transcriptase Polymerase Chain Reaction;RNA;Role;Sensory;sensory mechanism;sensory system;Stimulus;System;Taste Perception;taste system;Testing;tool;Toxin;transcriptome sequencing;vector

PROJECT_TITLE: Molecular basis of adaptation in a chemosensory system

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Aphasia;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation;Stroke

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: This project seeks to increase the functional impact of established aphasia treatment by combining the benefits of complementary learning approaches through adaptive timing models. Successful outcomes will show that adaptive computer-based treatments provide a novel way to produce large, durable, and generalizable improvements and will develop the next generation of aphasia-specific timing and learning models. This study has high potential clinical impact as treatment paradigms from this study are clinically feasible and implementable in the near term.

PI_NAMEs: EVANS, WILLIAM STREICHER (contact)

PROJECT_TERMS: adaptive learning;Address;Affect;Aftercare;Algorithms;Anomia;Aphasia;aphasia rehabilitation;Back;Brain Injuries;Clinical;clinical practice;Clinical Trials;Combined Modality Therapy;Complex;Computer software;Computers;Data;Data Set;design;Development;effective intervention;Equilibrium;flexibility;Frustration;Future;Hour;improved;improved outcome;Individual;individual patient;innovation;interest;Intervention;Language Disorders;Learning;Literature;Memory;model building;Modeling;Names;Nature;neglect;Neuronal Plasticity;next generation;novel;open source;Outcome;Outcome Study;Participant;Patients;Performance;personalized medicine;Persons;Population;processing speed;Quality of life;Randomized;Reaction Time;Research;Retrieval;Schedule;Speech;Speed;standard care;Stroke;System;telehealth;Testing;theories;Time;Training;treatment research

PROJECT_TITLE: Integrating complementary learning principles in aphasia rehabilitation via adaptive modeling


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE Block of nerve conduction using applied electrical signals is a promising approach to control neural activity with myriad potential clinical applications including treatment of pain, diabetes, and heart failure. However, the continued development and clinical translation of electrical nerve block is limited by the lack of selectivity over which specific nerve fibers are blocked. We will design and test novel nerve block waveforms and electrodes that will enable the continued advance of medical device therapies.

PI_NAMEs: GRILL, WARREN M. (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Address;Algorithms;Anesthesia procedures;Animal Model;Animals;Autonomic Dysfunction;autonomic nerve;Axon;bioelectronics;C Fiber;Cervical;Charge;chronic pain management;clinical application;clinical translation;Complex;Computer Models;design;Development;Diabetes Mellitus;Diameter;Discontinuous Capillary;Electric Stimulation;Electrodes;Elements;Engineering;engineering design;experimental study;Family suidae;Fiber;Frequencies;Geometry;Heart failure;Heart Rate;Horns;Human;in vivo;in vivo evaluation;Inflammation;Measures;Medical Device;Nature;Nerve;Nerve Block;Nerve Fibers;neural;Neural Conduction;neuroregulation;novel;Outcome;Pain management;particle;Performance;Peripheral;Peripheral Nerves;Physiologic pulse;Physiological;preclinical study;preservation;Rattus;response;sciatic nerve;Shapes;Signal Transduction;Technology;Testing;therapeutic target;tool;Training;Translations;Vagus nerve structure

PROJECT_TITLE: Optimized Electrical Block of Peripheral Nerves

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative This application aims to develop a structured, on-site summer environmental health sciences research program for high school teachers and students from three Indigenous communities in the Northern Plains. High school teacher-student teams will conduct high-quality, locally relevant environmental health sciences research through collaboration with Columbia University and Missouri Breaks Industries Research Inc (MBIRI) researchers that collectively have decades of experience in environmental health sciences research. Through this research as well as through developing professional skills, both for students and teachers, we ultimately aim to enable the participants to pursue research and professional careers in environmental health sciences/STEM, and, ultimately, to contribute to the prevention and control of diseases of environmental origin inclusively and with diverse perspectives.

PI_NAMEs: NIGRA, ANNE E (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Admission activity;American Indians;career;Cheyenne;Collaborations;college;Communication;Communities;community advisory board;community engagement;community-centered;Creativeness;design;Discipline;disorder control;Education;education research;Educational Activities;Educational Curriculum;Educational workshop;Employment;Employment Opportunities;Ensure;Environmental Health;Ethics;experience;Faculty;Future Teacher;geographic barrier;Goals;health science research;Health Sciences;high school;High School Faculty;high school program;High School Student;Indigenous;indigenous community;Individual;Industry;Joints;meetings;Mentors;Mentorship;Mission;Missouri;North Dakota;Northern Plains;Occupations;Oral;Participant;posters;Prevention;Process;Program Accessibility;programs;Public Health Schools;Recording of previous events;recruit;Research;Research Personnel;Research Priority;Research Project Grants;response;Rural;Schools;Science;science teacher;Scientist;Sioux Indians;Site;skills;South Dakota;STEM field;Structure;Students;success;summer research;Supervision;symposium;teacher;technical college;Time;Training;Training Activity;Training and Education;Translational Research;Tribes;undergraduate student;Universities;Update;virtual;Work;Writing

PROJECT_TITLE: Environmental Health Research for Teachers and High School Students (EARTH) in the Great Northern Plains


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_DEPT: CHEMISTRY

PHR: PROJECT NARRATIVE Treatment-resistant prostate cancer negatively impacts thousands of men every year, and new therapeutic strategies are urgently needed to improve patient outcomes. This work will evaluate therapeutic opportunities for the long noncoding RNA (lncRNA) SChLAP1, an underexplored driver of aggressive prostate cancer, with the objective of validating drug-like small molecules that inhibit its oncogenic functions. The long-term goal of this work is to yield a precision medicine- based strategy for aggressive and treatment-resistant prostate cancer while helping to establish lncRNA targeting as a therapeutic paradigm in oncology.

PI_NAMEs: HARGROVE, AMANDA E (contact);SOMARELLI, JASON ANDREW

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: American;Architecture;Binding;Binding Proteins;Binding Sites;Biological;Biological Assay;Biological Markers;Blood;cancer cell;Cause of Death;cell motility;Cell Survival;Cells;Cessation of life;Chromatin;Chromatin Remodeling Factor;Chromosomes;Clinical;Complex;Data;Development;DNA;DNA Binding;enzalutamide;Evaluation;Evolution;exosome;Follow-Up Studies;Future;Genomics;Goals;hormone therapy;improved;in vivo;insight;intermolecular interaction;Invaded;knock-down;Knowledge;Laboratories;Lead;Libraries;Ligands;liquid biopsy;Longterm Follow-up;Malignant neoplasm of prostate;Maps;Mass Spectrum Analysis;men;Metastatic Prostate Cancer;migration;Modeling;Molecular;mortality;multiple datasets;Neoplasm Metastasis;New Agents;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Oncology;Outcome;overexpression;Patient-Focused Outcomes;Pharmaceutical Preparations;Phenotype;precision medicine;prevent;Primates;Process;Proliferating;Prostate;prostate cancer progression;Prostate Cancer therapy;protein complex;Proteins;Resistance;RNA;Role;Scaffolding Protein;screening;Site;small molecule;standard of care;Structure;success;SWI/SNF Family Complex;Therapeutic;Therapeutic Agents;therapeutic target;therapeutically effective;therapy resistant;tool;Transcript;Untranslated RNA;Urine;validation studies;Work

PROJECT_TITLE: Therapeutic Targeting of The Long Noncoding RNA SCHLAP1 in Aggressive Prostate Cancer


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE The proposed studies will advance our understanding into the complexity of subcellular lipid and protein metabolism and signaling. The data gleaned from these studies will help advance our understanding into the underlying mechanisms of metabolic diseases and help facilitate therapeutic or nutritional avenues positively impact human health.

PI_NAMEs: MASHEK, DOUGLAS G (contact)

PROJECT_TERMS: Affect;aging related disease;Architecture;Area;Biochemical;Biochemical Pathway;Bioenergetics;Biogenesis;Cardiovascular Diseases;Cell Physiology;cell type;Cells;Cellular biology;Characteristics;Cirrhosis;comorbidity;Coupling;Data;Development;Endoplasmic Reticulum;Energy Metabolism;Etiology;Fasting;fatty acid oxidation;Fatty Acids;feeding;Functional disorder;Glean;Health;Hepatic;High Fat Diet;Human;imaging approach;innovation;Isotopes;Laboratories;Link;lipid metabolism;Lipids;Liver;liver biopsy;Liver diseases;Malignant Neoplasms;Membrane;Membrane Lipids;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;Mitochondria;mitochondrial membrane;mitochondrial metabolism;mouse model;Mus;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutritional;Organelles;oxidation;Oxidative Phosphorylation;Pathway interactions;Physiological;Play;protein metabolism;Proteins;Proteome;Proteomics;Publishing;Research;Risk;Role;Route;sensor;Signal Transduction;superresolution imaging;superresolution microscopy;Testing;Therapeutic;Time;trafficking;transcriptome sequencing;Work

PROJECT_TITLE: Lipid droplets and the compartmentalization of subcellular metabolism


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Immunotherapy;Nanotechnology;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: NARRATIVE Advanced stage ovarian cancer often spreads along currents of abdominal fluid and remains the leading cause of deaths from gynecologic tumors in the US. These currents confer fluid shear stress on ovarian cancer metastases, which changes the molecular characteristics of the tumors and makes them more resistant to chemotherapy. This proposal will develop a light-activatable nanotechnology to improve photoimmunotherapy and overcome fluid shear stress-induced chemoresistance in ovarian cancer.

PI_NAMEs: HUANG, HUANG CHIAO  (contact);RIZVI, IMRAN

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: 3-Dimensional;Abdomen;Abscopal effect;Address;Adhesions;Animal Model;Animals;anti-tumor immune response;Antibody Activation;Artificial nanoparticles;Ascites;Biodistribution;Biometry;Cancer Biology;cancer cell;Cancer Patient;cancer therapy;cancer type;Carboplatin;Carcinomatosis;Cause of Death;Cell Death;Cell Line;Cell Physiology;Cells;Characteristics;Chemoresistance;Chemosensitization;chemotherapy;Cisplatin;Clinic;Clinical;Cytoskeleton;density;design;Development;Diffuse;Disease Resistance;DNA;Dose;dosimetry;Drug Kinetics;Effectiveness;Engineering;Epidermal Growth Factor Receptor;Female Genital Neoplasms;fluorescence imaging;Goals;Greater sac of peritoneum;Gynecologic Oncology;Image;image guided;image-guided drug delivery;Immune;Immune mediated destruction;Immunocompetent;Immunoconjugates;immunogenic cell death;immunoregulation;improved;in vivo;individual patient;insight;intraperitoneal;Knowledge;Leadership;Light;light dosimetry;Liquid substance;malignant ascites;Malignant neoplasm of ovary;Malignant Neoplasms;migration;Mitochondria;Modeling;Modification;Molecular;Molecular Profiling;Monitor;mouse model;multidisciplinary;Mus;nano;nanoparticle;nanoscale;Nanotechnology;nanotechnology platform;Neoplasm Metastasis;Nodule;Operative Surgical Procedures;Optics;Outcome;Ovarian;ovarian neoplasm;Pathway interactions;patient derived xenograft model;patient prognosis;Patients;Perfusion;Peritoneal;Peritoneal Fluid;Pharmaceutical Preparations;Phenotype;photoimmunotherapy;Photosensitizing Agents;Physiological;Platinum;Platinum Compounds;Play;Proliferating;receptor;Recurrence;Regimen;Research;Residual state;Resistance;response;Role;Route;Safety;safety assessment;shear stress;Signal Transduction;standard care;Stress;Surface;T-Lymphocyte;targeted biomarker;targeted delivery;targeted treatment;taxane;Technology;Testing;Therapeutic;Therapeutic Index;three-dimensional modeling;Time;Tissues;tumor;Tumor Burden;Tumor Debulking;Tumor Immunity;tumor immunology;Tumor-associated macrophages;uptake;Xenograft procedure

PROJECT_TITLE: Targeting Fluid Stress-induced Chemoresistance in a 3D Carcinomatosis Perfusion Model Using Mechanism-based Photo-immunoconjugate Nanoparticles

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Lymphatic Research;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Granulomas are a hallmark of Mycobacterium tuberculosis (Mtb) infection; but not all granulomas are successful at eliminating Mtb. This proposal seeks to unravel the differences in local adaptive immune responses between successful (Mtb eliminated) and unsuccessful (Mtb persists) granuloma outcomes in both lung and lymph node tuberculosis. The ultimate goal is to use this knowledge to guide the selection of appropriate antigens to re-elicit a successful response through vaccination.

PI_NAMEs: ROY CHOWDHURY, ROSHNI  (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Acid Fast Bacillae Staining Method;adaptive immune response;Adult;Animal Model;Antigens;Architecture;Bacillus;BCG Live;Biological Response Modifiers;candidate identification;Catalogs;Cause of Death;CD8-Positive T-Lymphocytes;cell mediated immune response;Cells;Cellular Immunity;Clinical;comparative;complementarity-determining region 3;Computational algorithm;Data;design;Development;DNA;draining lymph node;Effector Cell;effector T cell;Epitopes;Focal Infection;Genetic Transcription;Goals;Granuloma;Granulomatous;Hilar;Histologic;HIV;HIV Seronegativity;Human;Immune;Immune response;Immunity;Immunization;Individual;Infection;Inflammatory;inflammatory milieu;innovation;insight;interest;Knowledge;Lesion;Licensing;Lung;Lung Diseases;Lung infections;lung lesion;Lymph Node Mapping;Lymph Node Tuberculosis;lymph nodes;Lymphatic System;machine learning algorithm;Maps;Mediastinal;Methods;mimetics;Modification;Molecular;Mus;mycobacterial;Mycobacterium bovis;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;Myeloid Cells;Necrosis;nonhuman primate;novel vaccines;Organ;Organoids;Outcome;outcome disparities;pathogen;Pathogenesis;Patients;Phenotype;Population;public database;pulmonary granuloma;Pulmonary Tuberculosis;Reaction;Research;response;Site;Specimen;Staging;Stains;stem;Sterilization;Structure;Swelling;T cell receptor repertoire sequencing;T cell response;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Thoracic Lymph Node;Tissues;trafficking;transcriptomics;transmission process;Tuberculosis;tuberculosis granuloma;tuberculosis immunity;Tuberculosis Vaccines;Vaccination;Vaccine Design;Vaccines;Variant

PROJECT_TITLE: The human lung and lung-draining lymph node response to Mycobacterium tuberculosis

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Narrative This Outstanding Investigator Award R35 program will determine how cells that regulate blood clotting contribute to diseases of the heart, lung, and blood. Results generated my lead to new diagnostics and/or therapies for patients who suffer from heart attacks, sepsis, or blood disorders.

PI_NAMEs: WEYRICH, ANDREW S (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Address;Award;Biology;Blood;Blood coagulation;Blood Platelets;Cells;Clinic;clinical investigation;Disease;Eukaryotic Initiation Factor-4E;Gene Expression;Gene Expression Regulation;Health;Heart;Heart Diseases;Hematological Disease;Human;inhibitor;Knowledge;Lead;Lung;Lung Diseases;Megakaryocytes;Mus;Myocardial Infarction;novel diagnostics;novel therapeutics;Pathway interactions;Patients;programs;Research;Research Personnel;response;Role;Sepsis;Testing

PROJECT_TITLE: Translational Control of Megakaryocyte and Platelet Gene Expression in Disease


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Human Genome;Infertility;Pediatric;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative  Assisted Reproductive Technologies have helped many couples worldwide to conceive children. However, adverse metabolic and cardiovascular outcomes have been observed, which are associated with ART procedures. Using our advanced model for IVF, this proposal will study reproductive outcomes in offspring induced by ART and the underlying sex specific mechanisms involved. Considering that healthy offspring is one of the main goals of ART, it is critical that these offspring are not wholly dependent upon ART.

PI_NAMEs: RHON CALDERON, ERIC ALEJANDRO (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Abnormal placentation;Academia;Adult;Adult Children;Adult women;Adverse effects;Affect;Age;Androgen Receptor;assisted reproduction;Assisted Reproductive Technology;Birth;bisulfite;bone age;Breeding;Cardiovascular system;Cells;Child;Cleavage Under Targets and Release Using Nuclease;Clinic;Clinical;Complex;Conceptions;Couples;Data;Dehydroepiandrosterone Sulfate;Development;DNA Methylation;drivers of aging;embryo cryopreservation;embryo culture;Ensure;Epigenetic Process;Estrogen Receptor 2;Exhibits;Fellowship;Female;female reproductive system;Fertility;Fertilization in Vitro;Fetal Growth Retardation;Fetus;Focus Groups;Future;Gene Expression;Genes;Genetic;Germ Cells;girls;Gland;Goals;Gonadal structure;Health;Histologic;Histones;Human;human old age (65+);improved;in vitro Model;Individual;Infertility;Inherited;Injections;Intracytoplasmic Sperm Injections;Laboratories;leydig interstitial cell;Life;life span;Link;Litter Size;Liver;Luteinizing Hormone;male;Male Genital Organs;Metabolic;Methodology;Methods;Methylation;methylation pattern;methylome;Morphology;Mothers;mouse model;Mus;offspring;Organism;Outcome;Ovarian;Ovarian aging;Ovary;Parents;Pathway interactions;Physiological;Physiology;Post-Translational Protein Processing;Pregnancy;Pregnancy Complications;Preimplantation Diagnosis;Premature Birth;Premature Ovarian Failure;Procedures;Proteins;Proteome;receptor expression;reproductive;reproductive function;reproductive outcome;Reproductive system;Research;Research Personnel;Reserve Cell;Risk;sertoli cell;Severities;sex;Sex Ratio;Sexual Development;Site-Directed Mutagenesis;Somatic Cell;sperm cell;stillbirth;success;System;Techniques;Technology;Teenagers;Testis;Tissues;tool;Training;transcriptome;transcriptome sequencing;Uterus;Work

PROJECT_TITLE: Assessment of reproductive outcomes on adult offspring from in vitro fertilization using a mouse model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-A(20)L]


ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Although numerous urinary tract infection (UTI) vaccines have been developed and tested over the past 30 years, no effective vaccine has yet emerged. We recently developed a novel vaccination strategy and formulation that resulted in the complete eradication of uropathogenic bacteria harboring in the bladder of UTI prone mice for the first time. We wish to undertake additional studies in mice to optimize the vaccine delivery method and identify surrogates of vaccine efficacy which will facilitate first-in-man studies.

PI_NAMEs: ABRAHAM, SOMAN N (contact);STAATS, HERMAN F

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Adjuvant;Age;Antibodies;Antigens;appendage;Bacteria;Bacterial Adhesins;Bacterial Infections;Bacterial Vaccines;Bladder;Bladder mucosa;Blood;CD4 Positive T Lymphocytes;Cells;Clinical;Clinical Research;Clinical Trials;Country;cytokine;Data;Defect;draining lymph node;effectiveness testing;Epithelial Cells;Epithelium;Escherichia coli;Escherichia coli Infections;Escherichia coli Vaccines;experience;Female;first-in-human;Flare;Formulation;Future;Hair;Human;IgG1;Immune;Immune response;Immunity;Immunization;Immunize;Immunoglobulin A;Immunoglobulin G;Infection;Interferon Type II;Interleukin-2;Intramuscular;Intravesical Administration;Invaded;Longevity;Mediating;Methods;Mucous Membrane;Mus;nanoparticle;Nature;novel;novel vaccines;oral bacteria;pathogen;patient population;Patients;Phase I Clinical Trials;Positioning Attribute;prevent;Property;recruit;Recurrence;response;Sampling;success;Suppositories;Testing;Th1 Cells;Time;trafficking;type 1 fimbriae;Urethra;Urinary tract infection;Urine;Uropathogenic E. coli;Vaccinated;Vaccination;vaccination strategy;Vaccine Antigen;vaccine delivery;vaccine efficacy;vaccine strategy;vaccine trial;Vaccinee;Vaccines;Vagina;Woman

PROJECT_TITLE: A novel vaccination strategy to curb recUTIs

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE Cholera is a devastating diarrheal illness currently taking lives in poverty-stricken countries around the world. This study proposed will shed light on importance of posttranscriptional and posttranslational regulation of virulence genes during V. cholerae infection, with the goal of better understanding V. cholerae stress responses and pathogenesis and, potentially, discovering novel treatment options for the cholera disease.

PI_NAMEs: ZHU, JUN  (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Affect;antioxidant enzyme;Bacteria;Binding;Biochemical;biological adaptation to stress;Biological Assay;Catalysis;Cholera;coping;Country;Cues;Cysteine;Cytometry;diarrheal disease;Disease;disulfide bond reduction;Enzymes;Gene Activation;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic approach;Genetic Transcription;glutaredoxin;Glutathione;Goals;gut colonization;Host Defense;human pathogen;Image;In Vitro;in vivo;Infant;Infection;Ligation;Link;mass spectrometric imaging;Mediating;Messenger RNA;Molecular;Molecular Chaperones;mouse model;novel;Oxidation-Reduction;Oxidative Stress;Pathogenesis;pathogenic bacteria;Post-Translational Protein Processing;Post-Translational Regulation;posttranscriptional;Poverty;Production;programs;protein function;Protein S;Proteins;Proteomics;Reactive Oxygen Species;Regulation;Repression;response;RNA;RNA Binding;Signal Transduction;Small Intestines;spatiotemporal;Stimulus;Stress;Sulfhydryl Compounds;System;Testing;tool;Transcriptional Regulation;transcriptome;Untranslated RNA;Vibrio cholerae;Vibrio cholerae infection;Virulence;virulence gene

PROJECT_TITLE: sRNA-regulated S-glutathionylation controls Vibrio cholerae virulence

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

ORG_STATE: TX

PHR: Narrative The sense of taste allows us to identify nutrients and avoid toxins within food, which is essential to maintain health and homeostasis. Taste dysfunction can lead to malnutrition and a decreased quality of life, but identifying the underlying causes and potential treatments for taste dysfunction is hindered by a limited understanding of how taste receptor cells and peripheral gustatory neurons re-establish connections in the taste bud during taste receptor cell turnover. This proposal seeks to define synaptic partnerships and dynamics during the continual turnover of taste receptor cells.

PI_NAMEs: LANDON, SHANNON MARIE (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Biological Assay;Brain;Calcium;Cell Differentiation process;Cells;Circumvallate Papilla;cohort;Complex;Consummatory Behavior;Data;density;design;Development;Engineering;experimental study;Fiber;Food;Functional disorder;Fungiform Papilla;Ganglia;Goals;Grant;Half-Life;Hand;Health;Homeostasis;Hour;Image;in vivo;Individual;inhibitor;innovation;Label;Larynx;life span;Light;Location;Longevity;Maintenance;Malnutrition;Maps;Methods;Microscopy;Modeling;Molecular;Mus;nerve supply;neurogenetics;Neurons;novel;Nutrient;Peripheral;Population;postsynaptic;precursor cell;presynaptic;prevent;Process;promoter;Proteins;Quality of life;Receptor Cell;reconstitution;Sampling;sensory system;SHH gene;Signal Transduction;Site;Stimulus;Structure of geniculate ganglion;Synapses;Synaptic Cleft;Synaptic Membranes;System;Taste Buds;Taste Disorders;Taste Perception;taste system;Techniques;Technology;Testing;Time;Tissues;tool;Toxin;Transgenic Mice;two photon microscopy;Variant;Viral;Visualization;Work

PROJECT_TITLE: Defining the Connectivity and Dynamics of Peripheral Sour Taste Circuits


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ROCHESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Caenorhabditis elegans has been a workhorse for gene discovery and pathway analysis, and is the only established system where high-throughput genetic analysis can be conducted in the context of a living multi-cellular organism. The goal of this research is to develop viral vector-based technologies to facilitate large scale genetic screens based on targeted gene overexpression, which would be of wide interest within the C. elegans community and fuel years of genetic discovery across a range of disciplines. Our goals are to achieve targeted gene activation in C. elegans using vesicular stomatitis virus to deliver a single guide RNA (CRISPRa), and to develop Orsay virus as a vector to exogenously deliver genes of interest into C. elegans.

PI_NAMEs: FERRAN, MAUREEN C;SAMUELSON, ANDREW VAUGHN (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Acceleration;Aging;Animals;Area;Biological;Biological Models;Biological Phenomena;biological systems;Caenorhabditis elegans;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;COVID-19 pandemic;CRISPR interference;CRISPR screen;CRISPR/Cas technology;Development;Discipline;Disease;Double-Stranded RNA;Escherichia coli;expression vector;feeding;flexibility;follow-up;Foundations;functional genomics;Gene Activation;gene delivery system;gene discovery;Gene Expression;Gene Targeting;Genes;Genetic;genetic analysis;genetic approach;Genetic Screening;Genomic approach;Goals;grasp;Guide RNA;Health;high throughput screening;Human;improved;Infection;Innate Immune Response;innovation;insight;interest;Intestines;Investigation;knock-down;large datasets;Large-Scale Sequencing;Libraries;Light;Low Density Lipoprotein Receptor;Mediating;Messenger RNA;Methods;model organism;Modernization;mutant;Natural Immunity;Nematoda;Open Reading Frames;Organism;overexpression;pathogen;Pathogenicity;Pathway Analysis;Phenotype;Population;Process;Production;promoter;Promoter Regions;Protein Isoforms;Reagent;receptor;recombinant viral vector;Recombinants;Regulation;Reporter Genes;Research;RNA;RNA delivery;RNA Interference;screening;success;System;Systems Biology;Technology;Testing;Tissues;tool;Transcription Coactivator;Transgenic Animals;Transgenic Organisms;uptake;usability;Variant;vector;Vesicular stomatitis Indiana virus;Viral;Viral Genome;Viral Vector;Virion;Virus;Virus Diseases;virus host interaction;Work

PROJECT_TITLE: Viral vector-mediated gene activation to facilitate large-scale genetic analysis in Caenorhabditis elegans.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-M(82)S]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARATIVE The misregulation of proteins involved in gene silencing is proposed to play a causative role in a subset of pediatric gliomas associated with poor prognosis. This research proposal will define the mechanisms of how these proteins affect gene expression to promote tumorigenesis. Findings from our project will facilitate the development of targeted therapies for these clinically challenging tumors that lack effective therapies.

PI_NAMEs: LEWIS, PETER W (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Affect;Affinity;antitumor effect;Binding;Biochemical;Biochemistry;Biological Assay;Brain;Catalysis;Cell Differentiation process;Cell Proliferation;Cells;Childhood Glioma;Chromatin;Clinical;Complex;CpG Islands;Data;Development;diffuse midline glioma;effective therapy;Elements;Ependymoma;Exhibits;Foundations;Future;Gene Expression;Gene Expression Profile;Gene Silencing;Genes;Genetic;genome-wide;Genomics;Glioma;Goals;Health;Histone H3;histone modification;Histones;Human;insight;interdisciplinary approach;Investigation;Knowledge;loss of function mutation;Lysine;Malignant - descriptor;Malignant Neoplasms;Methionine;Methods;Methylation;Molecular;mutant;neoplastic cell;novel;oncohistone;Pathogenesis;Phenotype;Phosphorylation;Play;Polycomb;Positioning Attribute;Post-Translational Protein Processing;Post-Translational Regulation;Posterior Fossa;PRC1 Protein;pre-clinical;Prognosis;programs;Proliferating;promoter;Proteins;recruit;Regulation;Repression;Research Proposals;Residual state;Resistance;Role;Site;Surface;targeted treatment;Testing;theories;Therapeutic;Therapeutic Intervention;therapeutic target;tumor;Tumor Suppressor Genes;tumorigenesis;tumorigenic;Work

PROJECT_TITLE: Understanding the regulation of PRC2 activity by EZHIP and the K27M oncohistone in pediatric gliomas

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Cardiac muscle cells have highly specialized pathways to ensure the quality of muscle proteins that are required for contraction. Genetic mutations that impair key proteins in these pathways, are implicated in causing human cardiac muscle weakness resulting in heart failure and premature death. In this proposal, we examine the mechanisms for development of cardiomyopathy by one such mutation, namely R120G in a chaperone protein, alpha-B crystallin (HSPB5), to understand the efficacy of stimulating autophagic pathways for mitochondrial quality control in preventing protein aggregates and cardiomyopathy.

PI_NAMEs: DIWAN, ABHINAV  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Ablation;Adaptor Signaling Protein;Adult;Adverse effects;Affect;Arginine;Attenuated;Autophagocytosis;autosome;Biological Models;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cell Death;Cell Line;Cells;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Coupled;CRISPR/Cas technology;Crystallins;Cytosol;Data;Development;DNA Sequence Alteration;Ensure;Excision;experimental study;Functional disorder;Funding;Genes;Genetic;Glycine;Grant;Heart failure;heart function;Heart Transplantation;Heat shock proteins;Human;human induced pluripotent stem cells;Impairment;induced pluripotent stem cell;Knock-in;life span;Lysosomes;Maintenance;Mammalian Cell;Mediating;Mitochondria;Mitochondrial Proteins;Modeling;Molecular Chaperones;mouse model;Mus;Muscle Proteins;Muscle Weakness;mutant;Mutation;Myocardial dysfunction;Myocardium;Natural Immunity;neonatal mice;novel;overexpression;Pathology;Pathway interactions;pharmacologic;Point Mutation;Positioning Attribute;premature;Premature Mortality;preservation;prevent;Process;promoter;protein aggregation;protein expression;Proteins;proteotoxicity;Quality Control;Reagent;Role;Sarcomeres;Structure;superresolution imaging;Testing;Therapeutic;Tissues;TRAF2 gene;Transgenic Mice;Treatment Efficacy;Troponin T;uptake;Visualization;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Mitophagy and Cardiac Myocyte Protein Aggregation

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Osteoarthritis

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Osteoarthritis is a severely debilitating disease with no disease-modifying treatments. Although it is considered primarily a disease of the elderly, sports-related injuries can lead to post-traumatic osteoarthritis in people of all ages. Molecular mechanisms regulating osteoarthritis are poorly understood, and in this application, we propose in-depth investigations into the development of a calcium/calmodulin-dependent protein kinase family member as a new generation therapeutic target that protects against trauma-induced osteoarthritis, representing a major breakthrough in anti-osteoarthritis treatment.

PI_NAMEs: SANKAR, UMA  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Ablation;Adenosine Monophosphate;Affect;Age;aggrecan;Apoptosis;articular cartilage;Attenuated;bone cell;Bone remodeling;Bone Spur;Ca(2+)-Calmodulin Dependent Protein Kinase;Cartilage;cartilage degradation;cell type;Cells;Cellular Metabolic Process;Chondrocytes;Complex;Cre lox recombination system;curative treatments;cytokine;Data;debilitating pain;Deformity;Degenerative polyarthritis;Development;Disease;Disease Progression;Down-Regulation;Elderly;Etiology;Family member;Functional impairment;gain of function;Gender;Generations;Genetic;Goals;healing;Heredity;Hypertrophy;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;insight;Interleukin-1 beta;Investigation;Joint Capsule;joint injury;Joints;Knee;Knockout Mice;Ligaments;Link;loss of function;Macrophage;Medial meniscus structure;Mediating;Meniscus structure of joint;mitochondrial dysfunction;Mitogen-Activated Protein Kinases;Molecular;Morphology;mouse model;Muramidase;Mus;novel therapeutic intervention;Obesity;Operative Surgical Procedures;Osteitis;Osteoblasts;Osteoclasts;Outcome;overexpression;Oxidative Stress;p38 Mitogen Activated Protein Kinase;Pain;Pain management;Pathogenesis;Pathology;Pathway interactions;Persons;pharmacologic;Phosphotransferases;Play;prevent;Process;Proliferating;Protein Kinase;Protein-Serine-Threonine Kinases;Regulation;Replacement Arthroplasty;response;response to injury;Role;Signal Pathway;Signal Transduction;Sports;subchondral bone;Surgical Models;Synovial Membrane;Synovitis;T-Lymphocyte;Tamoxifen;Testing;Tetracyclines;Therapeutic;therapeutic target;Tissues;Trauma;Traumatic Arthropathy

PROJECT_TITLE: CaMKK2 Signaling in Osteoarthritis

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Women's Health Research

ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Relevance to public health Cell motility is a fundamental cell behavior that contributes to normal immune system function and is hijacked by cancer cells to spread, and we have developed a simple yet powerful animal model to study cell motility and engulfment (cells eating other cells). Our work has led to a novel understanding of a class of human immunodeficiencies and a novel strategy to improve cancer therapy. The current proposal is to uncover additional molecular mechanisms of cell motility and engulfment for the benefit of human health.

PI_NAMEs: MONTELL, DENISE J. (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Adhesives;Animal Model;Anterior;B-Lymphocytes;Basement membrane;cancer cell;cancer immunotherapy;cancer therapy;cell behavior;Cell Communication;cell killing;Cell model;cell motility;Cell Polarity;Cell Shape;cell type;Cells;Cellular Morphology;Chemicals;chronic infection;cohesion;Complex;congenital immunodeficiency;constitutive expression;Cytoskeleton;Development;Disease;Drosophila genus;Eating;egg;Epithelial Cells;Exhibits;Family;fly;follow-up;Funding;Genes;Genetic Models;Germ-Line Mutation;Goals;Guanosine Triphosphate Phosphohydrolases;Health;Hematopoietic;Human;human disease;Hyperactivity;Imaging Techniques;immune system function;immunodeficiency;improved;in vivo;in vivo Model;inhibitor;insight;Investigation;Macrophage;Mediating;migration;Molecular;Monomeric GTP-Binding Proteins;Mutation;Natural regeneration;Neoplasm Metastasis;Normal tissue morphology;novel;novel strategies;Nurses;Oocytes;Oogenesis;optogenetics;Ovary;Pathway interactions;Patients;Phagocytes;Phagocytosis;photoactivation;premature;Process;programs;Property;protein complex;Public Health;recruit;Regulation;rho;Role;Signal Transduction;spatiotemporal;Structure;Surface;System;T-Lymphocyte;Testing;tumor;Work

PROJECT_TITLE: Spatiotemporal regulation of collective cell behaviors in Drosophila

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative Malfunctioning mitochondria contribute to the pathogenesis of several diseases of the outer retina such as AMD, Stargardt disease, cone-rod dystrophies and Retinitis Pigmentosa. Understanding mitochondrial dynamics in photoreceptors will help prevent the dysfunction of this essential organelle. Maintaining healthy mitochondria can delay the onset and progression of photoreceptor degeneration.

PI_NAMEs: BROCKERHOFF, SUSAN E (contact);HURLEY, JAMES BRYANT

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Age related macular degeneration;Biogenesis;Biological Models;Biology;Blood Vessels;cell type;circadian;circadian regulation;Circadian Rhythms;Cone;cone-rod dystrophy;Darkness;Disease;Ensure;Environment;Equilibrium;experience;Exposure to;Functional disorder;Glycolysis;Health;Homeostasis;Light;Maintenance;Metabolic;metabolic abnormality assessment;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Morphology;Motility;mouse model;Movement;Mus;Neurons;Organelles;Pathogenesis;photoreceptor degeneration;Photoreceptors;prevent;Process;Production;Radiation;Retina;Retinitis Pigmentosa;Stargardt's disease;Stress;Structure;Synapses;System;Vision;Work;Zebrafish

PROJECT_TITLE: Photoreceptor Mitochondria and Ca2+ Dynamics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(02)M]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PUBLIC HEALTH RELEVANCE STATEMENT (NARRATIVE) The COVID-19 pandemic is the most threatening public health challenge in the 21st century – the number of cumulative cases has reached 184.8 million as of July 7, 2021 with 3.996 million deaths (case-fatality rate of 2.2%), making COVID-19 the third leading cause of death in the US in 2020. Before effective measures such as mRNA vaccines are developed, non-pharmaceutical interventions (NPIs) are key for effective control; following development, optimal vaccine allocation becomes vital. This research explores novel NPI and vaccine allocation strategies using simulations for controlling COVID-19 and other infectious diseases (pandemic preparedness).

PI_NAMEs: NISHI, AKIHIRO  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Address;Age;Agreement;Application procedure;Area Under Curve;Behavior;Behavioral Sciences;Binding;Businesses;California;Case Fatality Rates;Cause of Death;Cessation of life;Circulation;Cities;Communicable Diseases;Communities;Country;County;COVID-19;COVID-19 pandemic;Crowding;Data;Development;Diagnosis;Disease;Disease Outbreaks;disorder control;dynamic system;Early Diagnosis;Early Intervention;Economics;Employee;epidemic response;Epidemiology;ethnic disparity;Ethnic Origin;Event;Exhibits;Face;Failure;Fatigue;France;Friends;Friendships;Goals;high risk;Home;Hour;Household;improved;Individual;Infection;infection risk;Influenza;Intervention;Investigation;Japan;Knowledge;Location;Masks;mathematical model;Mathematics;Measures;Mental Health;Modeling;Network-based;Nonlinear Dynamics;novel;novel vaccines;Older Population;operation;pandemic preparedness;pathogen;Pattern;Persons;physical conditioning;Pilot Projects;Play;Predisposition;Public Health;public health relevance;Quarantine;Race;racial disparity;Reproduction;Research;RNA vaccine;Role;Sampling;Schools;Signal Transduction;simulation;Social Distance;social group;Social Network;social norm;Social Policies;social structure;socioeconomics;sound;South Korea;Specific qualifier value;stay-at-home order;Structure;Students;Subgroup;success;Techniques;theories;Time;transmission process;Tuberculosis;Vaccinated;vaccine development;vaccine distribution;vaccine strategy;Vaccines;Variant;Workplace

PROJECT_TITLE: Network Intervention Planning without Actual Network Data for Infectious Disease Control

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Few treatment options are available for T cell cancers that affect ~100,000 patients worldwide each year. The current proposal will generate a type of immunotherapy using new antibodies that specifically kill the T cell cancers and retain enough healthy T cells to maintain a functioning immune system. This immunotherapy may improve patient outcome and limit side effects associated with traditional chemotherapies.

PI_NAMEs: PAUL, SUMAN  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Affect;Animal Model;Antibodies;Antibody Therapy;Antigen Targeting;Antigens;B-Cell Leukemia;B-Lymphocytes;beta Chain Antigen T Cell Receptor;Binding;Biochemical;Biological Assay;Bispecific Antibodies;cancer cell;Cancer cell line;Cancer Patient;Cancerous;career;CD19 gene;Cell surface;Cells;chemotherapy;Clinical Trials;Cytometry;cytotoxicity;cytotoxicity test;Data;Development;Engineering;experience;feasibility testing;Funding;Future;Genes;Goals;high dimensionality;Human;Immune;Immune response;Immune system;immune system function;Immune Targeting;Immunity;Immunoglobulin Constant Region;Immunosuppression;Immunotherapy;improved;improved outcome;In Vitro;in vivo;in vivo evaluation;Laboratories;Lead;leukemia/lymphoma;Libraries;Malignant - descriptor;Malignant Neoplasms;Measures;Mediating;Monoclonal Antibodies;mouse model;MS4A1 gene;Mus;novel therapeutic intervention;pathogen;Patient-Focused Outcomes;Patients;Phage Display;Phase;Physicians;Population;pre-clinical;preservation;pressure;programs;quantitative imaging;Receptor Down-Regulation;receptor downregulation;receptor expression;Receptor Signaling;Relapse;Research;safety testing;Scientist;side effect;Signal Transduction;skills;Surface Antigens;T-Cell Depletion;T-cell diversity;T-Cell Leukemia;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Testing;therapeutic evaluation;therapy resistant;translational research program;tumor;Validation

PROJECT_TITLE: TCR Targeting Antibodies for the Treatment of T cell Cancers

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Metastasis is the predominant killer of cancer patients. Understanding how tumor cells respond to and evade cancer suppression mechanisms in order to metastasize is essential for the development of therapies that effectively prevent this lethal process. This project aims to characterize the mechanism by which the secreted protein APOE acts via its receptor LRP1 on melanoma cells to inhibit their invasion and metastasis, with potential future applications in therapeutically exploiting this mechanism.

PI_NAMEs: ADAKU, NNEOMA  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Animal Model;Apolipoprotein E;Binding;Biological Assay;Cancer Biology;Cancer Patient;Cell Line;Cell surface;cell type;Cells;Cessation of life;collaborative environment;Conflict (Psychology);CRISPR/Cas technology;Cytoplasm;Data;Doctor of Philosophy;Functional disorder;Future;Gene Expression;Gene Targeting;Genetic;Genetic Transcription;genetic variant;Genetically Engineered Mouse;Glycoproteins;Goals;Human;Human Cell Line;Immunotherapy;improved;In Vitro;in vivo;Institution;Invaded;Knock-out;Laboratories;LDL-Receptor Related Protein 1;Lipoprotein Receptor;Literature;Mediating;Melanoma;Melanoma Cell;Melanoma patient;Metastasis Suppression;Metastatic Melanoma;Metastatic Neoplasm to the Lung;MicroRNAs;migration;Modeling;Molecular;Mouse Cell Line;mouse model;Mouse Strains;mRNA sequencing;Mus;mutant;Mutate;Mutation;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;novel therapeutics;overexpression;pharmacologic;Phenotype;Phenylalanine;Phosphorylation;Phosphotransferases;Physicians;prevent;Process;programs;promoter;Protein Secretion;Proteins;receptor;Receptor Signaling;repaired;Repression;Resistance;Role;role model;Scientist;Signal Pathway;Signal Transduction;Skin Cancer;Smooth Muscle Myocytes;Surface;Testing;Therapeutic;Therapeutically Targetable;therapy development;Training;transcriptome sequencing;transcriptomics;Tumor Escape;tumor progression;Tyrosine;Tyrosine Phosphorylation;Universities;Vascular Smooth Muscle;vascular smooth muscle cell migration;Work

PROJECT_TITLE: Elucidating the Function of LRP1 in APOE-mediated Suppression of Melanoma Metastasis


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE The short-term goal of this K99/R00 application is the development of the PI as an independent investigator skilled in the use of participatory systems science and community-engaged approaches to select and adapt an intervention, lung cancer prevention and risk reduction interventions, and intervention development and implementation science. The proposed research will select and adapt an intervention protocol to reduce lung cancer risk among Central Appalachian Kentucky women through a community-engaged process and will pilot test the selected intervention using a two-armed randomized controlled trial. The long-term goal is to reduce lung cancer disparities among Appalachian women and for the PI to become an independent researcher and expert in community-engaged intervention development for cancer risk reduction among Appalachian women.

PI_NAMEs: THOMPSON, JESSICA RUTH (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: 18 year old;Active Learning;Address;Appalachian Region;Area;Attitude;Awareness;Behavior;Behavior Therapy;Behavioral;Cancer Center;Cancer Etiology;cancer health disparity;Cancer Intervention;cancer risk;care giving burden;career development;Chronic Disease;Chronic stress;clinical center;Clinical Sciences;Communities;community center;community collaboration;community engaged approach;community engaged intervention;community engagement process;community partners;community-level factor;Coping Behavior;Country;County;Death Rate;Development;Development Plans;disorder prevention;disparities in women;Disproportionately impacts women;Economically Deprived Population;Effectiveness of Interventions;Enrollment;Environment;Environmental Exposure;Environmental Risk Factor;Equity;Evidence based intervention;experience;falls;Farm;Funding;Future;Gender;geographic disparity;Goals;Health;health care availability;health disparity;health disparity populations;health economics;health equity;Health Technology;High Risk Woman;human centered design;implementation cost;implementation science;improved;Incidence;Individual;Insurance;Intervention;intervention mapping;intervention refinement;Intervention Studies;Intervention Trial;Kentucky;Knowledge;Literature;lung cancer prevention;Malignant neoplasm of lung;Malignant Neoplasms;men;Mentors;Mentorship;Methods;Mining;model building;Modeling;mortality;NCI-Designated Cancer Center;Needs Assessment;non-smoker;Participant;Passive Smoking;Perception;Persons;Phase;pilot test;Population;Postdoctoral Fellow;Poverty;Preventive;Preventive screening;Preventive service;primary care provider;Process;Protocols documentation;Psychosocial Factor;public policy on tobacco;Quality of life;Radon;Randomized, Controlled Trials;Research;Research Methodology;Research Personnel;Risk;Risk Factors;Risk Reduction;Rural;Rural Appalachia;Sample Size;satisfaction;Science;Scientist;Self Efficacy;Series;service providers;sex;skills;Smoking;social;socioeconomic disadvantage;socioeconomic disparity;Source;Specificity;Surveys;System;Targeted Research;therapy development;Training;training opportunity;Translational Research;Trust;United States National Institutes of Health;Universities;Water;Woman;women's diagnosis;Women's mortality

PROJECT_TITLE: Reducing Lung Cancer Risk among Appalachian Women Using Community‐Engaged Intervention Research


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Caregiving Research;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Depression;Disability Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention;Stroke;Telehealth

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Relevance. Caring for a family member after a stroke can be very difficult and worsen the physical and mental health of untrained caregivers. The TASK III intervention is a unique, comprehensive caregiver intervention program that enables caregivers to develop the necessary skills to manage care for the survivor, while also taking care of their own health.

PI_NAMEs: BAKAS, TAMILYN  (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Address;American;American Heart Association;care systems;caregiver interventions;Caregivers;caregiving;Caring;Chronic;Climacteric;Clinical Trials;Communication;cost;Data;depressive symptoms;diet and exercise;directed attention;disability;Education;efficacy testing;electronic book;Emotional;empowerment;Enrollment;expectation;experience;Family;Family Caregiver;Family member;Fatigue;Feasibility Studies;Funding;Future;Goals;Guidelines;Health;health assessment;health care service utilization;Health Personnel;Health Technology;health training;Healthcare;improved;innovation;Institutionalization;Intervention;intervention program;Learning;Long term disability;Managed Care;Mediator;Mental Health;novel;Nurses;Outcome;Pain;Patient Self-Report;Patients;Perception;physical conditioning;Physical Function;Policies;post intervention;preference;premature;primary outcome;Problem Solving;Program Evaluation;programs;psychoeducation;Public Health;Publishing;Randomized;Randomized Controlled Clinical Trials;Recommendation;recruit;Rehabilitation therapy;Reporting;resource guides;Risk;satisfaction;secondary outcome;Self Efficacy;Self Management;Shortness of Breath;skills;Sleep;societal costs;Stress;stress management;Stressful Event;Stroke;stroke intervention;stroke survivor;Survivors;symptom self management;Symptoms;Technology;telehealth;Telephone;Testing;Time;Time Management;Training;Translating;trend;Videoconferencing;web site;Well in self

PROJECT_TITLE: Telehealth Assessment and Skill-Building Intervention for Stroke Caregivers (TASK III)

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative: Lipoprotein(a) [Lp(a)], the major lipoprotein carrier of oxidized phospholipids, has consistently been implicated as a risk factor for calcific aortic valve disease through human epidemiological and genetic studies. However, the mechanisms by which Lp(a) and its oxidized phospholipids (OxPL) mediate the development and progression of calcific aortic valve disease in vivo are not known. This proposal will fill these gaps in knowledge through comprehensive analysis of aortic valves, including quantitative molecular imaging of calcification, proteomics, and hemodynamics in transgenic mice expressing Lp(a) that bind OxPL and mutant Lp(a) that do not bind OxPL, which are uniquely available only in our laboratory.

PI_NAMEs: YEANG, CALVIN  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Address;Affect;Aging;aging population;aortic valve;aortic valve disorder;aortic valve replacement;apolipoprotein B-100;apolipoprotein Lp(a+);Apolipoproteins B;Award;Binding;Binding Sites;Blood Vessels;calcification;career;Caring;Cessation of life;Characteristics;Cholesterol;Clinical;Clinical Trials;clinically relevant;comparative;comparison control;conventional therapy;Data;design;Development;Diet;Disease;disorder risk;Echocardiography;efficacy testing;Elderly;Epidemiology;epidemiology study;Failure;Funding;Genetic;Genetic study;Goals;Heart failure;hemodynamics;high risk;Histologic;Human;human disease;In Vitro;in vivo;in vivo Model;Incidence;Individual;Inflammatory;insight;interstitial cell;Knowledge;Laboratories;Left;lipid metabolism;lipidomics;Lipids;Lipoprotein (a);Lipoproteins;liquid chromatography mass spectrometry;Lysine;Measurement;Mediating;Mediator;Medical;Mentors;Mentorship;Minerals;Molecular;molecular imaging;Monitor;Morbidity - disease rate;mouse model;multidisciplinary;Mus;mutant;Mutation;natural antibodies;novel;novel therapeutics;Operative Surgical Procedures;osteogenic;Outcome;Pathogenicity;Pathway interactions;Patients;Phospholipids;Phosphorylcholine;Physicians;Physiologic intraventricular pressure;Population;prevent;Prevention therapy;Preventive therapy;Procedures;Process;Progressive Disease;Proteins;Proteomics;randomized, clinical trials;Research;Research Personnel;Risk;Risk Factors;Role;Scientist;skills;Stroke;Symptoms;targeted treatment;Techniques;Testing;Tissues;Training;Transgenic Mice;Transgenic Organisms;Translating;valve replacement;Variant;Work

PROJECT_TITLE: Defining the Role of Lipoprotein(a) and its Oxidized Phospholipids in the Development and Progression of Calcific Aortic Valve Disease Using Unique Transgenic Mouse Models

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Older adults experience declining mobility, which leads to diminished quality of life, high health care costs, and thus constitutes a major health care problem. It is unclear what factors lead to mobility decline, but energy production by the mitochondrion is thought to play a role. This longitudinal study utilizes new methodology to measure systemic mitochondrial function in blood cells of older people over time, to understand the role of mitochondrial function in age-associated physical function decline.

PI_NAMEs: MOLINA, ANTHONY J;SHIVA, SRUTI  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Age;age related;age related changes;age related decline;aged;Aging;aging population;Ancillary Study;Biochemical;Bioenergetics;Biological Assay;Biological Markers;Biology;Biopsy;Blood;Blood Cells;Blood Platelets;Body System;Brain;Cardiovascular system;Cells;Central Nervous System;Chemicals;Clinical;cohort;Complex;cost effective;Coupled;Data;Denervation;Electron Transport;Enrollment;experience;extracellular;Fatty Acids;follow-up;Functional disorder;Genus Hippocampus;Glucose;Glycerophosphates;Glycolysis;Health Care Costs;Healthcare;Heart;Heterogeneity;Human;Individual;Knowledge;Lead;Link;Longitudinal Studies;longitudinal, prospective study;Lung;Measurement;Measures;Mediator;Methodology;Methods;Mitochondria;mitochondrial dysfunction;Mobility decline;Molecular Analysis;Morbidity - disease rate;mortality;Muscle;muscle form;Muscle function;Muscle Mitochondria;Musculoskeletal;Myocardium;novel;older adult;Older Population;Organ;Outcome;Oxidative Phosphorylation;Parents;Participant;Performance;Peripheral Blood Mononuclear Cell;Permeability;Persons;Physical Function;Physical Performance;Play;Population;Production;Quality of life;Research;Resolution;Role;sarcopenia;Schedule;Site;Skeletal Muscle;Solid;Spirometry;synergism;System;Testing;therapy development;Time;Tissues;Visit;Walking

PROJECT_TITLE: The relationship between blood based bioenergetics and muscle function, mobility, and aging

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative The Mouse Peroxisome Research Resource (MPRR) serves as a central resource for mouse models and monoclonal antibodies for basic and translational research in peroxisome biology. The MPRR is a community-driven resource that enhances basic research to better define the roles peroxisomes play in human health and accelerate preclinical testing of therapeutic hypothesis aimed at developing and implementing improved treatments for peroxisomal disorders.

PI_NAMEs: BRAVERMAN, NANCY ELISE;HACIA, JOSEPH G (contact);ZUBERI, AAMIR RAFIQ

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Acceleration;Address;Alleles;Antibodies;base editing;Basic Science;Biochemical;Biological;Biological Assay;Biology;Body System;career;Cells;Clinical;clinical phenotype;Communities;Complex;conditional knockout;cost effective;Cryopreservation;Data;Deposition;Development;Disease;disease model;Ensure;Feedback;Fees;Free Will;Functional disorder;Generations;Genes;Genetic;genetic resource;genome editing;Genotype;Goals;Health;Human;Hybridomas;Immunohistochemistry;Immunologics;improved;Inbreeding;Individual;Infrastructure;innovation;Institution;interest;Knock-out;Knockout Mice;Knowledge;Laboratories;Laboratory Research;Legal;Licensing;Location;Measurement;member;Mendelian disorder;Metabolic;Methods;Mission;Modality;model development;Modeling;Monoclonal Antibodies;monoclonal antibody production;mouse genetics;mouse model;Mus;mutant;Mutant Strains Mice;novel;Organelles;outreach program;Peroxisomal Disorders;peroxisome;Phenotype;Play;Preclinical Testing;Proteins;rational design;Reagent;Recommendation;repository;repository infrastructure;Research;Research Personnel;Resources;Role;Science;Services;Signal Pathway;Signal Transduction;Specimen;Standardization;Structure;tandem mass spectrometry;targeted treatment;The Jackson Laboratory;therapeutic evaluation;Therapeutic Intervention;therapy development;Tissues;Translational Research;United States National Institutes of Health;Universities;Western Blotting

PROJECT_TITLE: A Mouse Model Resource for Peroxisome Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-A(55)R]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Epstein-Barr Virus (EBV) infects nearly all individuals and alters cellular metabolism upon infection of naïve B cells in order to establish a latent memory B cell reservoir and promote tumorigenesis in immune compromised hosts. As such, discerning the mechanisms by which EBV induces metabolic changes is imperative for understanding EBV-mediated tumorigenesis and the impact of metabolism on normal B cell maturation in the germinal center. The proposed studies will further elucidate the role of the viral protein EBNA-LP in remodeling cellular metabolism through transcriptional co-activation of metabolic genes and may ultimately lead to potential therapeutic targets of EBV-related malignancies.

PI_NAMEs: CABLE, JANA  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Adult;Alanine;Antigens;B-Lymphocytes;Binding;Binding Proteins;Biological Assay;cell growth;cell growth regulation;Cell Maturation;Cell Proliferation;Cell Survival;Cells;Cellular Metabolic Process;Chromatin;Chromatin Remodeling Factor;Co-Immunoprecipitations;Collagen;Complex;Data;Disease;Electron Microscopy;Enzymes;EP300 gene;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Epstein-Barr Virus Nuclear Antigens;Epstein-Barr Virus-Related Malignant Neoplasm;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genus Hippocampus;Glucose;Goals;Growth;Herpesviridae;Higher Order Chromatin Structure;Human Herpesvirus 4;Hydroxyproline;Immune;Immune response;Immunofluorescence Immunologic;In Vitro;Individual;Infection;Infectious Mononucleosis;insight;latent infection;Leucine;lymphoblastoid cell line;Lymphoid Tissue;Lymphoma;Mediating;Membrane;Memory;Memory B-Lymphocyte;Metabolic;Metabolic Activation;Metabolism;Modeling;Modification;Molecular;mutant;Mutation;new therapeutic target;novel;Nuclear;Nuclear Protein;Oral;Oral cavity;oral cavity epithelium;Organelles;Outcome;Oxidative Phosphorylation;Oxygen Consumption;Patients;Peptides;Phase;Post-Translational Protein Processing;Procollagen-Proline Dioxygenase;Proline;promoter;Protein Family;protein oligomer;Proteins;recruit;Regulation;Role;Saliva;Site;stable cell line;Structure of germinal center of lymph node;T-Lymphocyte;therapeutic target;Tonsil;Transcription Coactivator;transcription factor;transcriptome sequencing;transmission process;tumorigenesis;Up-Regulation;Viral Proteins;Virus;Virus Diseases;YY1 Transcription Factor

PROJECT_TITLE: Metabolic regulation of Epstein-Barr Virus-infected tonsillar B cells by EBNA-LP


NIH_SPENDING_CATS: Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Orientia tsutsugamushi is an understudied bacterial pathogen and global health threat that causes scrub typhus, a potentially deadly disease that afflicts at least one million people each year. This project will determine how O. tsutsugamushi virulence factors called Anks modulate immune defense mechanisms. Doing so will expand understanding of how Orientia and similar pathogens manipulate host cell functions to cause disease and may identify novel targets for treating scrub typhus.

PI_NAMEs: CARLYON, JASON A (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: adaptive immunity;ANK1 gene;Ankyrin Repeat;Annual Reports;Antigen-Presenting Cells;Bacteria;Binding;Biological Assay;Blood Vessels;C-terminal;Case Study;Cell Nucleus;Cell Physiology;cell type;Cells;Cellular biology;Cessation of life;cohort;Complex;Coupled;Cytoplasm;Data;Defense Mechanisms;design;Development;Disease;Dominant-Negative Mutation;Endothelial Cells;Etiology;Evolution;F Box Domain;F-Box Motifs;functional mimics;functional outcomes;gain of function;Gene Expression;Genes;Genetic;global health;Hospitalization;Immune response;Immunity;Immunoprecipitation;immunoregulation;Impairment;in vivo;Infection;inhibitor;innovation;insight;Invaded;Knowledge;Leukocytes;Life;Link;Lysine;Mammalian Cell;Mass Spectrum Analysis;Mediating;Microbe;microbial;mimicry;multicatalytic endopeptidase complex;Mus;Natural Immunity;Nature;novel;Organ failure;Orientia tsutsugamushi;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Persons;Phosphotransferases;prevent;Preventive vaccine;protein protein interaction;Proteins;Role;screening;Scrub Typhus;SKP Cullin F-Box Protein Ligases;success;System;Testing;therapeutic target;Time;Toxic effect;Trans-Activators;Trees;Ubiquitin;ubiquitin ligase;Ubiquitination;Virulence;Virulence Factors;Yeasts

PROJECT_TITLE: Orientia tsutsugamushi Ank-host interactions in scrub typhus pathogenesis

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: ANN ARBOR

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The Michigan Institute for Clinical and Health Research at the University of Michigan seeks to develop a new postdoctoral T32 training program to prepare early-stage postdoctoral fellows for impactful careers in translational science and research. Trainees receive personalized support for their training needs, multi-level training to enhance their professional networks, communication and dissemination training for diverse audiences, and training in diversity, health equity, and inclusion. The overall objective of this training program is to help form the next generation of investigators that strive to improve the lives of individuals and their communities through translational science and research.

PI_NAMEs: ELLINGROD, VICKI L;HARTE, STEVEN EDWARD (contact)

PROGRAM_OFFICER_NAME: CONROY, JENNIE LYNN

PROJECT_TITLE: CTSA Postdoctoral T32 at the University of Michigan

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-6 (01)]


NIH_SPENDING_CATS: Infectious Diseases;Nutrition

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE While metal toxicity is broadly toxic to bacteria, how they respond to this toxicity and the order in which they do so remains unknown. This project will explore the effects of copper and zinc overabundance on Streptococcus pneumoniae to elucidate bacterial systems used to respond to metal stress, how the bacteria enact that response, and which systems are targets of metal stress.

PI_NAMEs: JOHNSON, MICHAEL DAVID LESLIE (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TITLE: Elucidating the Orchestrated Bacterial Response to Copper Toxicity

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative The goal of the described research program is to develop new classes of chemical compounds to be screened for efficacy against various diseases. The synthetic approach described in this proposal, which involves a tungsten-activated benzene substrate, is fundamentally different than other known approaches to cyclohexene and cyclohexane compounds, and allows access to new materials with widely diverse shapes that are rich in amines, amides, carboxylic acids, esters, and heterocyclic fragments groups that are ubiquitous in pharmaceutical agents. Access to such compounds improves the chances for the discovery and development of new medicines to improve public health.

PI_NAMEs: HARMAN, WALTER DEAN (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Rapid Synthesis of Topologically Complex Molecules with Tungsten Dearomatization Agents

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The genomes of multicellular organisms are utilized distinctly over time and space as cells multiply and specialize during normal development. Understanding this process is of critical biomedical significance, as mis-regulation of the human genome underlies many diseases, including the devastating ability of cancer cells to acquire drug resistance and to metastasize. Identifying the initial steps that poise developmental genes for activation or repression, providing a mechanistic understanding for how regulatory decisions occur, and discovering how cells aberrantly switch state in cancer are all critical goals of our research.

PI_NAMEs: KURODA, MITZI I (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: acquired drug resistance;Benchmarking;Binding;biological systems;cancer cell;Cancer Etiology;Cell Proliferation;cell type;Cells;Chromatin;Collaborations;Complement;Complex;Development;Developmental Gene;Disease;Drosophila genus;Drosophila melanogaster;Embryo;embryo cell;Epigenetic Process;epigenetic regulation;Event;fly;Funding;Fusion Oncogene Proteins;Gene Activation;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;Germ Lines;Goals;group competition;Human;Human Genome;knock-down;Light;Malignant Neoplasms;Mammalian Cell;Methods;Molecular;NCOA2 gene;Neoplasm Metastasis;Normal Cell;Organism;Pattern;Phenotype;Play;Polycomb;PRC1 Protein;Process;programs;protein complex;Protein Dynamics;Proteins;Regulation;Repression;Research;Resolution;response;Role;Specific qualifier value;System;Testing;Time;transcription factor;Transcriptional Regulation;Variant;Work;zygote

PROJECT_TITLE: Epigenetic regulation of transcriptional programming


NIH_SPENDING_CATS: Aging;Biotechnology;Clinical Research;Immunization;Infectious Diseases;Kidney Disease;Organ Transplantation;Prevention;Transplantation;Vaccine Related

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative People with immunocompromising conditions, including end stage renal disease (ESRD) and renal transplantation, are at increased risk of developing severe infections. Vaccination is the preferred mode of protection against infections but people with the highest risk of infectious morbidity tend to have poor responses to vaccines. This study will identify actionable inflammatory and/or metabolomic factors and immunogenomic characteristics associated with decreased responses to vaccines in people with ESRD with and without transplantation.

PI_NAMEs: WEINBERG, ADRIANA  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: 2019-nCoV;Acceleration;Acquired Immunodeficiency Syndrome;Address;Adult;Adverse drug effect;Affect;Age;Age Years;cell mediated immune response;Cells;Cellular Immunity;Characteristics;Clinical Trials;Clone Cells;congenital immunodeficiency;Defect;Disease;Dose;End stage renal failure;Filtration;Flow Cytometry;Funding;Genomics;Goals;Herpes zoster disease;Herpesvirus Type 3;high risk;Iatrogenesis;Immune;Immune response;Immunity;Immunization;Immunocompromised Host;immunogenicity;Immunogenomics;Immunologics;Immunology;immunosenescence;Immunosuppression;Impairment;improved;In Vitro;Infection;Inflammation;Inflammatory;Influenza;Kidney;Kidney Transplantation;Knowledge;Memory;Metabolism;metabolomics;Morbidity - disease rate;older adult;Participant;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Plasma;post-transplant;Predisposition;Randomized;Recombinants;Regimen;Research;Research Personnel;Resources;response;Risk;Role;Sampling;System;T cell response;T-Lymphocyte;Therapeutic immunosuppression;Training;Transplant Recipients;Transplantation;United States National Institutes of Health;Vaccination;Vaccines;Zoster Vaccine

PROJECT_TITLE: PERSISTENCE OF IMMUNE RESPONSES TO THE RECOMBINANT ZOSTER VACCINE IN IMMUNE COMPROMISED HOSTS WITH END-STAGE RENAL DISEASE WITH AND WITHOUT KIDNEY TRANSPLANTATION

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 JTS-I (S1)]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

PHR: Project Narrative Pseudomonas aeruginosa, which infects immunocompromised people, can communicate among its own populations using a signaling system called quorum sensing. We seek to understand how quorum sensing evolves over time and influences interactions with other microbes, with the idea that these studies will eventually lead to potential new treatments for bacterial infections.

PI_NAMEs: DANDEKAR, AJAI  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Bacteria;Bacterial Infections;Behavior;Cells;Coculture Techniques;Communication;Cooperative Behavior;Environment;Evolution;Funding;Gene Expression;Generations;Genetic;human pathogen;Immunocompromised Host;Individual;intercellular communication;interest;Knowledge;Microbe;microbial;Microbial Genetics;Modeling;Molecular Biology;Molecular Genetics;National Institute of General Medical Sciences;Organism;Persons;Population;Population Sizes;Pseudomonas aeruginosa;quorum sensing;response;Signal Transduction;Social Behavior;Social Interaction;System;Therapeutic;Time;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MRAF-C (01)]


ED_INST_TYPE: GRADUATE SCHOOLS

PHR: PROJECT NARRATIVE This project develops new methods for DEER spectroscopy. DEER is a technique that measures the internal motions of proteins, which are crucial for many molecular-level processes in the human body. The resulting data are essential for understanding the molecular basis of life and disease and for providing the knowledge base necessary to develop new drugs

PI_NAMEs: STOLL, STEFAN  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;Amino Acids;Bayesian Analysis;Biomedical Research;Computing Methodologies;Cryoelectron Microscopy;Data;Data Analyses;deep learning;Disease;drug development;Electrons;Environment;experimental analysis;Fluorescence Resonance Energy Transfer;Freezing;Goals;Human;Human body;innovation;insight;knowledge base;Label;Life;Measurement;Measures;Membrane Proteins;Methodology;Methods;millisecond;Modeling;Molecular;Molecular Conformation;Motion;nanoscale;novel therapeutics;Process;protein complex;Protein Conformation;Proteins;Reproducibility;Research Personnel;Spectrum Analysis;Structure;Techniques;Time;tool;X-Ray Crystallography

PROJECT_TITLE: DEER spectroscopy tools for probing protein conformational dynamics


NIH_SPENDING_CATS: Genetics

PHR: NARRATIVE Differences between cells determine how they respond when in a new environment or when challenged with a drug. However, quantifying differences between cells and measuring whether and how those differences dictate what cells do is challenging. This proposal describes the development and application of new methods to measure how cell-to-cell differences dictate response to challenges, including drugs used to treat human disease.

PI_NAMEs: FOWLER, DOUGLAS M (contact)

PROGRAM_OFFICER_NAME: KRASNEWICH, DONNA M

PROJECT_TERMS: biological heterogeneity;biological systems;Biology;Cell Physiology;Cells;Cellular Morphology;Development;Drug usage;Environment;fascinate;Funding;Genes;genetic variant;Genetic Variation;Heterogeneity;human disease;Human Genetics;Individual;insight;Measures;metabolomics;Methods;Molecular;mutation screening;non-genetic;novel strategies;Organism;Pharmaceutical Preparations;Phenotype;Population;protein function;protein structure;Proteins;Proteomics;response;Shapes;success;trait;transcriptomics;tumor;Variant;Work

PROJECT_TITLE: New approaches for investigating the causes and consequences of cellular heterogeneity


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative A defining feature of cells are membrane bilayers that separate them from their environment and, in human and other eukaryotic cells, delineate intracellular compartments with specialized functions. Here we address the fundamental question how cells make and maintain these membranes. Dysfunction in membrane lipid homeostasis is linked to a number of neurological disorders, including Alzheimer’s and Parkinson’s diseases, among many others. Our work will inform regarding disease mechanism, prerequisite for the development of therapeutic strategies.

PI_NAMEs: REINISCH, KARIN M (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Address;Alzheimer's Disease;aqueous;Autophagosome;Biogenesis;Cell membrane;Cells;Collaborations;Disease;Endoplasmic Reticulum;Environment;Eukaryota;Eukaryotic Cell;Family;Fatty Acids;Functional disorder;Grant;Homeostasis;Human;Hydrophobicity;Integral Membrane Protein;Laboratories;Link;lipid transfer protein;lipid transport;Lipids;Maintenance;Mediating;Membrane;Membrane Lipids;Molecular;Movement;Nervous System Disorder;Organelles;Parkinson Disease;Physiological;Physiology;Process;Proteins;Role;Site;therapeutic development;Time;Vesicle;Work;Yeasts

PROJECT_TITLE: Mechanisms in Membrane Dynamics

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Errors in cell division have been linked to developmental defects and disease in humans. We take inter- disciplinary approaches to decipher the molecular mechanisms required for accurate cell division. Our findings have the potential to facilitate the development of new therapeutic strategies based on targeting cell division and the cytoskeleton.

PI_NAMEs: KAPOOR, TARUN M. (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;ATP phosphohydrolase;Biochemical;Cell division;Cell Line;Cell Physiology;Cells;Cellular biology;Centrosome;Chemicals;Chromosomes;Complex;Cytoskeleton;Defect;Development;Disease;Dose;Goals;Hour;Human;Image Analysis;inhibitor;insight;interdisciplinary approach;Knowledge;Length;Light;Link;Malignant Neoplasms;Measures;meter;Microscopy;Microtubules;Mitosis;Molecular;Motor;nanoscale;Neurons;novel therapeutic intervention;novel therapeutics;Nuclear;Output;Permeability;Phenotype;Process;protein function;protein protein interaction;Proteins;Proteomics;quantitative imaging;Recombinants;Research;Resistance;self assembly;structural biology;Structure;Tubulin

PROJECT_TITLE: Chemical Biology of Cell Division


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: The Dartmouth Clinical and Translational Science Institute, SYNERGY, supports research and training that will speed the development of new treatments, diagnostics, programs, and services to improve the health of people everywhere. With our collaborators at MaineHealth, the University of Vermont, and elsewhere we are especially committed to improving healthcare delivery to individuals living in rural areas in northern New England and nationally.

PI_NAMEs: BERNSTEIN, STEVEN L (contact);PAULSEN, KEITH D.;TOSTESON, ANNA N. A.

PROGRAM_OFFICER_NAME: DOYLE, JAMIE MIHOKO

PROJECT_TERMS: Acceleration;Address;aging population;Area;Biological;Biomedical Engineering;Businesses;Center for Translational Science Activities;Chronic;Clinical;Clinical Research;Clinical Sciences;clinical translation;Collaborations;college;Communities;community engagement;community partners;Companions;Complex;COVID-19;COVID-19 pandemic;Data;Data Science;Data Scientist;Dedications;design;Development;Diagnostic;digital health;Disparity;early experience;Economics;Elements;Engineering;evidence base;Faculty;Fostering;Future;Geography;Goals;Health;health care delivery;health care settings;health equity;Health system;Healthcare;Healthcare Systems;Hospitals;human centered design;implementation science;improved;Individual;innovation;insight;Interest Group;Internet;Knowledge;Leadership;Learning;Machine Learning;medical schools;member;Mentored Clinical Scientist Development Program;Modeling;Neighborhood Health Center;New England;New Hampshire;next generation;novel;pandemic disease;Patients;Persons;Policy Making;Population;Process;programs;psychologic;Public Health;Reporting;Research;Research Personnel;Research Support;Resources;Rural;rural area;Rural Community;Rural Health;Rural Health Centers;rural health disparities;rural healthcare;Rural Population;Science;Scientist;Services;skills;social;Speed;substance use;System;telehealth;Therapeutic;Time;Training;translational model;translational pipeline;Translational Research;translational scientist;Transportation;United States Department of Veterans Affairs;Universities;vaccine hesitancy;Vermont;Work;Workforce Development;working group

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-9 (01)]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE. The Center for Clinical and Translational Science (CCTS) and its tristate Partner Network of eleven institutions in the Deep South are dedicated to improving health and advancing health equity in a region disproportionately burdened by chronic diseases. The Center will expand its diverse, highly-trained clinical and translational research workforce, assembling faculty, trainees, clinical research professionals and community stakeholders to create collaborative synergies in clinical and translational science research, to catalyze team science-driven investigation into new therapies and health care delivery paradigms and to enhance the dissemination and implementation of evidence-based knowledge toward health impact. This work will complement and inform translational research efforts to improve public health locally, regionally and beyond as the CCTS remains poised to serve as a national resource for responding to current and future public health emergencies.

PI_NAMEs: DELAFONTAINE, PATRICE ;GUTIERREZ, ORLANDO M (contact)

PROGRAM_OFFICER_NAME: ATIENZA, AUDIE A

PROJECT_TERMS: Acceleration;Address;Affect;Alabama;Area;Back;Bioinformatics;Biomedical Research;Biotechnology;burden of chronic illness;cardiometabolism;career;Chronic Disease;Clinical;clinical center;Clinical Research;Clinical Sciences;Clinical Trials;Communication;Communities;community partners;community partnership;Complement;Consultations;Country;COVID-19 pandemic;Data;Data Analytics;data interoperability;Dedications;Deep South;design;Development;digital;Disease;disease disparity;Disparity;Dissemination and Implementation;Diverse Workforce;Ecosystem;Ensure;Equity;Ethics;Evaluation;evidence base;Faculty;Feedback;Future;Goals;Growth;Health;health care delivery;health disparity;health equity;Health Sciences;Health system;Healthcare Systems;high dimensionality;improved;industry partner;Informatics;Infrastructure;innovation;insight;Institution;Intervention;Investigation;Knowledge;Leadership;Learning;Louisiana;Malignant Neoplasms;Medical center;Mentors;Mission;Mississippi;multidisciplinary;National Center for Advancing Translational Sciences;Neurologic;novel strategies;novel therapeutics;Patients;Persons;Pilot Projects;Population;Process;programs;Public Health;public health emergency;Public Health Informatics;Research;Research Methodology;Research Project Grants;research study;Research Support;Resource Informatics;Resources;Science;Scientific Advances and Accomplishments;Services;skills;Special needs;synergism;Talents;Testing;tool;Training;Training and Education;Training Programs;Translating;Translation Process;Translational Research;Trust;Universities;Vision;Work

PROJECT_TITLE: CTSA UM1 at the University of Alabama at Birmingham