ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Public Health Relevance Work by the applicants and collaborators has identified 3 candidate drugs for repositioning for alcohol use disorder (AUD) that are currently in different stages of clinical testing and that are likely to act at least in part via modulation of neuroinflammation. Using these 3 candidate drugs for AUD and a panel of selected anti- inflammatory drugs with different mechanisms of actions, we aim to reverse engineer the effects of alcohol on neuroinflammation to identify mechanisms behind alcohol-induced tissue damage and therapeutic efficacy. This approach is expected to highlight specific alcohol-induced inflammatory pathways of motivational significance and that their delineation will point to new and more effective therapeutic targets and medications for AUD.

PI_NAMEs: REPUNTE-CANONIGO, VEZ ;SANNA, PIETRO P (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Alcohol abuse;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol use disorder;Alcohols;Anti-Inflammatory Agents;Astrocytes;attenuation;base;Biochemical;Carbenoxolone;Chronic;Complex;drug action;drug candidate;drug repurposing;Effectiveness;Environmental Risk Factor;Enzyme-Linked Immunosorbent Assay;Gene Expression;Gene Expression Regulation;gene regulatory network;Genetic;Glucocorticoid Receptor;Glucocorticoids;Heavy Drinking;Human;Immunohistochemistry;Inflammasome;Inflammation;Inflammatory;inhibitor;Link;Microglia;Mifepristone;Modeling;Molecular;Monitor;Motivation;Neurobiology;Neurodegenerative Disorders;neuroinflammation;Neurons;new therapeutic target;Pathogenesis;Pathway Analysis;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Positioning Attribute;predictive modeling;Probenecid;Proteins;public health relevance;Rattus;receptor;Receptor Activation;Receptor Signaling;recruit;Regulation;research clinical testing;Reverse engineering;Role;Self Administration;Signal Transduction;Systems Biology;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;therapeutically effective;Tissues;TLR4 gene;transcriptome sequencing;Treatment Efficacy;treatment response;virtual;Western Blotting;Work

PROJECT_TITLE: Alcohol-Induced Neuroinflammation and AUD Therapeutic Mechanisms


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SYRACUSE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_FIPS: US

ORG_NAME: SYRACUSE UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative The proposed research addresses the critical public health need for sufficiently intense speech treatments, without which ~6 million Americans adults live with unresolved speech sound disorders. The project’s investigation of intensive motor-based treatment bootcamps and artificial intelligence-driven treatment potentiates an evidence-based paradigm shift in which combined speech-language pathologist/artificial intelligence service delivery overcomes existing access barriers to sufficiently intense treatment. The project is relevant to the NIDCD’s and NIH’s missions of conducting behavioral research to reduce disability, as those with unresolved speech sound disorders may experience reduced educational, social, emotional, and occupational outcomes throughout the lifespan.

PI_NAMEs: PRESTON, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acceleration;Address;Adolescent;Adult;Affect;aged;Agreement;algorithm training;Algorithms;American;Articulation Disorders;Artificial Intelligence;Behavioral Research;Case Study;Child;Chronic;Classification;classification algorithm;Clinical;clinical efficacy;Communication impairment;Consensus;design;Detection;Development;disability;Disease;Dose;Education;effective therapy;Emotional;evidence base;Evidence based practice;experience;Experimental Designs;Feedback;Frequencies;Goals;Human;improved;improved outcome;Individual;ineffective therapies;innovation;Investigation;Judgment;Language;Learning;life span;Mediating;Mission;Motor;motor learning;National Institute on Deafness and Other Communication Disorders;Occupational;optimal treatments;Outcome;Participant;Pathologist;Performance;Production;Public Health;Quality of life;Randomized, Controlled Trials;Recommendation;Research;Research Design;Residual state;Resources;service delivery;skills;social;sound;Speech;Speech Sound;Stimulus;System;Technology;Teletherapy;Testing;Therapeutic;Time;tool;Training;Treatment Efficacy;Treatment Failure;United States National Institutes of Health;web app;Work

PROJECT_TITLE: Intensive Speech Motor Chaining Treatment and Artificial Intelligence Integration for Residual Speech Sound Disorders

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Infectious Diseases;Radiation Oncology;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: CHAPEL HILL

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative  In the past few decades, the human papilloma virus (HPV) has been driving an epidemic of head and neck squamous cell carcinoma (HNSCC) emphasizing the need for a clear understanding of HPV-driven carcinogenesis in these tumors. The goals of this proposal are to characterize a previously unrecognized subset of HPV-associated HNSCC that harbors somatic inactivating mutations in NF-κB regulators and to explore roles of NF-κB signaling in an alternative mechanism of HPV tumorigenesis. This work should help to define an alternative mechanism through which HPV causes cancer in the head and neck, personalize cancer care and de-escalate therapy to improve quality of life amongst survivors, while providing a basis for discovery and testing of novel therapies that may benefit patients at high risk of dying from HPV-associated cancer.

PI_NAMEs: ISSAEVA, NATALIA ;YARBROUGH, WENDELL G (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: anti-tumor immune response;Automobile Driving;Bioinformatics;biological adaptation to stress;Biological Markers;Cancer Etiology;carcinogenesis;CD4 Positive T Lymphocytes;Cell Proliferation;Cells;cervical and uterine cancer;Characteristics;chemotherapy;Classification;Clinical Trials;cohort;Coupled;Cytoprotection;Data;Defect;Deglutition;Disease;Down-Regulation;effective therapy;Engineering;Epidemic;Episome;Etiology;Functional disorder;Gene Expression;Genes;Goals;Head and Neck Squamous Cell Carcinoma;Head and neck structure;high risk;HPV E7;HPV negative;human papilloma virus oncogene;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;immune cell infiltrate;improved;In complete remission;Incidence;Infiltration;Maintenance;Mediating;metaplastic cell transformation;Modeling;Morbidity - disease rate;Mutation;NF-kappa B;novel therapeutics;Oncology;oral HPV-positive head and neck cancers;Oxidative Stress;Papillomavirus Transforming Protein E6;Pathway Analysis;Pathway interactions;Patients;Pattern;personalized cancer care;Prognosis;Prognostic Marker;promoter;protective pathway;Quality of life;Radiation;Radiation therapy;Radiation Tolerance;Recurrence;Recurrent tumor;Reporting;response;Risk;Role;side effect;Signal Transduction;Speech;survival prediction;Survivors;Testing;Therapeutic;TNF receptor-associated factor 3;Tobacco;Treatment Failure;treatment response;tumor;tumor microenvironment;tumorigenesis;Viral Genes;Work

PROJECT_TITLE: Dissecting NF-kB pathway in HPV-associated head and neck cancer

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Gestational Diabetes and Pharmacotherapy (GAP) study is a randomized controlled trial that will investigate the optimal glycemic threshold for pharmacotherapy addition to medical nutrition therapy in GDM. The GAP study will promote standardization in GDM management and will have direct relevance for clinical practice.

PI_NAMEs: PALATNIK, ANNA  (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: active control;active control group;Acute;Address;adverse outcome;Agreement;Anxiety;Birth;Birth trauma;Black race;Cesarean section;Clinical;clinical practice;clinically relevant;Complications of Diabetes Mellitus;Data;diabetes management;Diabetes Mellitus;Disease Management;Disparity;ethnic minority;Ethnic Origin;Ethnic Population;evidence based guidelines;Exercise;Exposure to;Foundations;Frequencies;Gestational Age;Gestational Diabetes;Glucose;glycemic control;Goals;Guidelines;Health;health care delivery;healthy pregnancy;Heterogeneity;Hispanic;Hyperbilirubinemia;Hyperglycemia;Hypoglycemia;improved;Insulin;Interview;Lead;Level of Evidence;maternal hyperglycemia;maternal outcome;Maternal-fetal medicine;Medical Nutrition Therapy;Medication Management;Mental Depression;minority patient;National Institute of Child Health and Human Development;Neonatal;Neonatal Hypoglycemia;neonatal outcome;neonate;Obesity Epidemic;offspring;Outcome;Patient Outcomes Assessments;Patients;perceived stress;Perinatal mortality demographics;Pharmacotherapy;Pre-Eclampsia;predict clinical outcome;Pregnancy;pregnant;Premature Birth;prenatal exposure;prevent;Provider;Race;racial minority;racial population;Randomized;Randomized, Controlled Trials;Reduce health disparities;Respondent;response;Risk;Safety;safety assessment;Self Efficacy;Small for Gestational Age Infant;Standardization;standardize guidelines;standardize measure;standardized care;Strategic Planning;Stress;Surveys;Variant

PROJECT_TITLE: Gestational Diabetes and Pharmacotherapy (GAP) – A Randomized Controlled Trial Investigating Timing of Pharmacotherapy Initiation for Patients with Gestational Diabetes

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Colorectal Cancer;Digestive Diseases;Lung;Lung Cancer;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Cancer epidemiology is complex due to the long induction period between when a risk factor occurs and when a cancer develops. However, most of the cancer literature uses standard methodology to analyze cancer incidence and survival data. In the current application, we propose to make more efficient use of cancer incidence and survival data by considering four distinct types of innovations: (a) lethal cancer models to predict which disease-free subjects will die due to a specific cancer in the future, (b) latency models to make optimal use of repeated measures of exposure data, (c) cure models to assess which pre-diagnostic risk factors predict whether a patient will be cured of a cancer, and (d) Colorectal cancer screening models to incorporate previous colonoscopy data to more accurately predict future CRC risk.

PI_NAMEs: ROSNER, BERNARD A (contact)

PROGRAM_OFFICER_NAME: DIVI, RAO L

PROJECT_TERMS: adenoma;Advanced Development;Age;aged;Alcohol consumption;Aspirin;Beta Carotene;Biological;Birth;Body mass index;Breast;Breast Cancer Risk Factor;calcium intake;cancer diagnosis;cancer epidemiology;Cancer Model;Cancer Patient;cancer risk;cancer survival;carcinogenicity;Cessation of life;Colonoscopy;Colorectal Cancer;colorectal cancer progression;colorectal cancer risk;colorectal cancer screening;Complex;Contraceptive Usage;Data;Development;Diagnosis;Diagnostic;Disease;Exogenous Hormone Therapy;Exposure to;Folic Acid;follow-up;Future;Goals;High Risk Woman;Hormone replacement therapy;improved;Incidence;innovation;Intake;interest;Interruption;Lesion;Literature;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammographic screening;Measures;Methodology;Methods;Modeling;modifiable risk;mortality;Natural History;Nurses' Health Study;Oral Contraceptives;Outcome Assessment;parity;Patients;Physical activity;Polyps;Postmenopause;Predictive Factor;Predisposing Factor;Predisposition;Pregnancy Histories;premalignant;Premenopause;Prevention;Probability;Process;Processed Meats;prognostic model;Prospective Studies;Psychosocial Stress;Public Health;Recording of previous events;Research Personnel;Risk;Risk Estimate;Risk Factors;risk prediction;risk prediction model;screening;Smoking;Specific qualifier value;Survival Analysis;Time;Update;Woman;Work

PROJECT_TITLE: Methodologic Innovations in Cancer Epidemiology

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Our previous work identified a novel paracrine signaling between acetylcholine-producing immune cells and thermogenic beige adipocytes within subcutaneous fat. We propose to investigate the activation and regulation of this signaling pathway during metabolic adaptation. Insights gained from proposed studies may lead to new therapeutic targets counteracting human metabolic diseases.

PI_NAMEs: WU, JUN  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Ablation;Acetylcholine;Adipocytes;Adipose tissue;Adrenergic Receptor;Affect;Agonist;beta-2 Adrenergic Receptors;Calcium;cell type;Cells;Choline O-Acetyltransferase;cholinergic;Chronic;Communication;Complex;coping;Cre lox recombination system;Data;Defect;Diabetes Mellitus;diabetes pathogenesis;energy balance;experimental study;Fatty acid glycerol esters;feeding;Functional disorder;Genetic;Genetic Models;glycemic control;Hand;High Fat Diet;Homeostasis;Human;Immune;In Vitro;in vivo;insight;Insulin Resistance;interdisciplinary approach;Investigation;Ion Channel;Knock-in Mouse;Knock-out;loss of function;Macrophage;Mediating;Metabolic;Metabolic Diseases;Metabolism;Molecular;mouse model;Mus;new therapeutic target;Nicotinic Receptors;novel;Obesity;obesity development;Organism;paracrine;Paracrine Communication;Pathogenesis;Pathologic;pharmacologic;Physiological;Play;Production;recruit;Regulation;Reporter;response;Role;Series;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Source;Spatial Distribution;Streptozocin;Stromal Cells;subcutaneous;Testing;thermal stress;three-dimensional visualization;Tissues;tool;transcriptome;Visualization;Work

PROJECT_TITLE: The role of immune-adipocyte cholinergic signaling during metabolic adaptation and dysfunction

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Mental Health;Prevention

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The US Government is the leading funder of HIV prevention and care in low- and middle-income countries, and there is a need to allocate resources with evidence-based strategies proven to work in the most efficient manner possible. This project will provide needed policy and program advice on what is working in global HIV prevention based on the strength of evidence from the scientific literature using systematic reviews and meta- analyses to address the most salient needs emerging in the field, including the impact of COVID-19 on HIV services. The study will provide essential information to guide intervention programming to improve the public health impact of US investments in global HIV/AIDS prevention and control.

PI_NAMEs: SWEAT, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: Address;Adherence;Africa;AIDS prevention;Appointment;Area;Attention;Behavior;Behavioral;Caring;Characteristics;Client;Code;Collaborations;commune;Communities;Consensus;Cost Analysis;cost effectiveness;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data;data repository;Decentralization;Development;Disease;Effectiveness;evidence base;experience;Government;Grant;Guidelines;Health;Health Services Accessibility;HIV;Home;implementation intervention;improved;Information Retrieval;innovation;Intervention;intervention effect;intervention mapping;Intervention Studies;Investments;Journals;Link;Literature;low and middle-income countries;mathematical model;meetings;Mental Health;Meta-Analysis;Methods;Modeling;Outcome;Paper;Participant;Patients;Peer Review;Pharmaceutical Preparations;Policies;Population;pre-exposure prophylaxis;Prevention;Printing;Productivity;programs;prospective;Public Health;Publications;Publishing;rapid growth;Reaction;Reporting;repository;Reproductive Health;Research;Research Design;Resource Allocation;Risk;Role;Scientist;service delivery;Services;sexual and reproductive health;Shock;social;success;systematic review;Techniques;theories;therapy design;Time;Training;Training Programs;Translational Research;United States National Institutes of Health;Update;vaccine access;Vaccines;Work

PROJECT_TITLE: The Evidence Project: Systematic Reviews of Critical HIV Interventions, and Disruption in HIV Services from COVID-19 in LMIC


NIH_SPENDING_CATS: Aging;Diabetes;Nutrition;Obesity;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative This study will provide a mechanistic explanation for the clinical observations that type-2 diabetes in patients is linked with telomere shortening of adipocyte progenitor cells in fat tissue and that obesity predisposes to type-2 diabetes. It will also investigate how this process is linked with the circadian rhythm and test whether nutritional intervention can delay replicative senescence in adipose tissue and metabolic disease development.

PI_NAMEs: KOLONIN, MIKHAIL G (contact);MAHAN, KRISTIN ECKEL

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Ablation;Acceleration;Adipocytes;adipose derived stem cell;Adipose tissue;Aging;Brown Fat;Caloric Restriction;Cell Aging;Cell Death;cell type;Cells;circadian;Circadian Dysregulation;circadian regulation;Circadian Rhythms;Clinical;Clinical Data;Competence;Data;Deposition;Development;Diabetes Mellitus;Diet;diet-induced obesity;Dietary Intervention;Disease;energy balance;exhaustion;Fatty acid glycerol esters;Fatty Acids;feeding;Fibrosis;Foundations;Functional disorder;Genetic;Gluconeogenesis;Glucose;Glucose Intolerance;Growth;Health;High Fat Diet;Hyperplasia;Hypertrophy;Hypoxia;Inflammation;innovation;Insulin;Insulin Resistance;Intervention;ketogenesis;Knock-out;Knockout Mice;Laboratories;Length;Leucocytic infiltrate;Life Style;Link;lipid biosynthesis;Lipids;Lipolysis;Liver;Maintenance;Measures;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Methods;Mitochondria;Modeling;mouse model;Mus;Muscle;Non-Insulin-Dependent Diabetes Mellitus;Nutritional;nutritional approach;obese person;Obesity;old mice;Organ;Outcome;Pancreas;Pathologic;Patients;PDGFA gene;pharmacologic;Phenotype;Physiological;Physiology;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor alpha Receptor;Platelet-Derived Growth Factor Receptor;Population;prevent;Process;Production;progenitor;Proliferating;recruit;Regulation;Reporting;response;self-renewal;sex;Signal Transduction;Skeletal Muscle;stem cell differentiation;stem cell population;stem cell proliferation;stem cells;Telomerase;telomere;Telomere Shortening;Testing;TGFBR2 gene;Time-restricted feeding;Tissues;Transforming Growth Factor beta;translational impact;Triglycerides;Vascularization

PROJECT_TITLE: Metabolic consequences of adipocyte progenitor replicative senescence: mechanism and intervention

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE The overarching goal of 21EH Scholars is to expand and diversify the pool of students entering the environmental health sciences workforce. We propose to do accomplish this goal by providing summer and academic-year, mentored research experiences in environmental health sciences research labs at UNC-CH to students from diverse backgrounds including those who attend NCCU, a partner HBCU, and transfer students from the NC community college system. In addition to supporting the development of undergraduate researchers, the program also will provide professional development for students and robust mentorship training to prepare participating mentors to create inclusive learning environments.

PI_NAMEs: BAINES, ANTONIO THOMAS;GRAY, KATHLEEN M (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Address;African American population;Alaska Native;American Indians;Area;Behavioral Sciences;Biological;career;Clinical Sciences;cohort;Communication;Communities;community college;community engagement;cultural competence;Development;Disabled Persons;Discipline;Droughts;Education;educational atmosphere;Educational Curriculum;Employment;Engineering;Environment;Environmental Health;Environmental Medicine;environmental stressor;Ethnic Population;Evidence based practice;experience;Faculty;Fostering;Goals;graduate student;Health;Health Personnel;Health Professional;health science research;Hispanic;Historically Black Colleges and Universities;Hour;Human;implicit bias;Individual;Knowledge;medical schools;member;Mentors;Mentorship;Monitor;Natural Disasters;next generation;North Carolina;Participant;Pathway interactions;peer;Persons;Planets;Population;Postdoctoral Fellow;posters;Problem Solving;programs;racial bias;racial population;recruit;Research;Research Personnel;Scholars Program;Science;Scientist;Sex Bias;skill acquisition;skills;social;STEM career;STEM field;student participation;Students;success;summer research;symposium;System;Time;Toxicology;Training;transfer student;undergraduate research experience;undergraduate student;Underrepresented Minority;Underrepresented Students;Universities;university student;Woman;Work

PROJECT_TITLE: 21st Century Environmental Health Scholars: Increasing Diversity in Environmental Health Sciences Through Mentored Research Experiences (21EH Scholars)


ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE This proposed research project has significant public health implications given the profound increase in the incidence of diabetes mellitus and the ensuing exponential increase in health care expenditures required to treat its complications. Diabetic complications are optimally prevented when euglycemia is achieved through the use of insulin infusion pumps that approximate normal glucose homeostasis for insulin-dependent diabetes patients. The resultant knowledge will extend infusion pump lifetime by providing additional insights into the causal role of mast cell activation and products following insulin excipient and device induced tissue reaction to allow the identification of new targets that will advance the development of more effective and specific approaches that will optimize future diabetes therapies.

PI_NAMEs: KLUEH, ULRIKE  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Abdomen;absorption;Achievement;Address;Advanced Development;Affect;Air;American;Arachidonic Acids;arm;Biological;Blood Glucose;blood glucose regulation;Body Surface Area;Buttocks;Cannulas;Cell Communication;Cell Degranulation;Cell Line;Cells;Characteristics;chemokine;Cicatrix;clinical efficacy;clinically relevant;Complications of Diabetes Mellitus;Connective Tissue;Cre-LoxP;Cresol;Cutaneous;cytokine;cytotoxic;cytotoxicity;Data;Dermal;Devices;diabetes management;Diabetes Mellitus;diabetes mellitus therapy;Disease;Dose;Enzyme Inhibition;Epidemic;Epidermis;euglycemia;Event;Excipients;Excision;extend lifespan;Fibrosis;first responder;flexibility;Formulation;Future;Genes;glycemic control;Glycosylated hemoglobin A;Goals;Health Expenditures;Human;Hypoglycemia;improved;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;Inflammatory Response;Infusion procedures;Infusion Pumps;injection/infusion;Injections;innovation;insight;Insulin;Insulin Infusion Systems;insulin mediators;Insulin-Dependent Diabetes Mellitus;Knowledge;Laboratories;Leukocytes;Life;Longevity;Macrophage;manufacture;mast cell;MCL1 gene;Mediator;Methodology;Molecular;mouse model;Mus;neutrophil;new technology;novel;Pathology;Pathway interactions;Patients;pediatric patients;Peptide Hydrolases;Persons;Phagocytosis;Pharmaceutical Preparations;Pharmaceutical Solutions;pharmacokinetics and pharmacodynamics;Phenols;Phenotype;Phosphotransferases;porcine model;Practice Management;practice setting;pre-clinical;preservation;prevent;Preventive therapy;Probability;Proteins;Public Health;Publishing;Puncture procedure;Reaction;recruit;Recurrence;Research Project Grants;Role;Rotation;Site;Skin;Skin injury;skin irritation;skin organogenesis;Skin Tissue;Sterility;subcutaneous;Subcutaneous Tissue;System;Technology;Testing;Time;tissue injury;Tissues;Toxic effect;Transgenic Mice;uptake

PROJECT_TITLE: Infusion device optimization by addressing root causes of the inflammatory response

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Hematology;Rare Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative This grant is to support the investigators of the Dana-Farber/Partners Cancer Care (DF/PCC) NLAPS in their efforts to provide scientific leadership and accrual to the national fight against cancer. The Harvard-affiliated DF/PCC investigators have for decades been leaders in developing critical clinical trials that have set the standard for cancer treatment in the US, in developing the scientific rationale for those trials, and in enrolling patients on the most important studies that move the field forward. Investigators from DF/PCC have made and continue to make contributions as leaders in critical NCTN trials that have in recent years improved outcomes for patients with prostate cancer, lung cancer, breast cancer, melanoma, myeloma, leukemia, ovarian cancer and other tumor types, helping reduce the burden of cancer in American society, and improved survival for patients in the US and across the world.

PI_NAMEs: BURSTEIN, HAROLD JOHN (contact);KIBEL, ADAM S;RYAN, DAVID P

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Adherence;Adult;American;American College of Radiology Imaging Network;anti-cancer research;Awareness;Biometry;Breast;Cancer Burden;cancer care;Cancer Patient;cancer therapy;cancer type;Caring;Clinical;Clinical Research;Clinical Treatment;clinical trial implementation;Clinical Trials;Clinical Trials Cooperative Group;Colorectal;Committee Membership;Communities;Conduct Clinical Trials;Dana-Farber Cancer Institute;design;Development;Discipline;Disease;Eastern Cooperative Oncology Group;Ensure;experience;experimental study;fighting;Funding;Future;General Hospitals;Generations;Goals;Grant;Head and neck structure;Hospitals;imaging modality;imaging study;improved;improved outcome;Infrastructure;innovation;Institution;Lead;Leadership;leukemia;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Massachusetts;Medical;Melanoma;member;Mentors;Mission;Modality;Modeling;Monitor;multimodality;Multiple Myeloma;National Cancer Institute;National Clinical Trials Network;novel;Oncology;Operative Surgical Procedures;participant enrollment;Patient-Focused Outcomes;Patients;Pilot Projects;Positioning Attribute;pre-clinical;Principal Investigator;programs;Prostate;Protocols documentation;Radiation therapy;rare cancer;Research;Research Personnel;Role;Sarcoma;Scientific Advances and Accomplishments;Site;Societies;standard care;Support Groups;support network;Supportive care;Symptoms;Teaching Hospitals;Training;Translational Research;Translations;treatment trial;trial design;tumor;Woman;Work

PROJECT_TITLE: NCTN Lead Academic Participating Site at Dana-Farber/Partners Cancer Care


ORG_CITY: DAVIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Narrative Obesity will soon be the leading cause of preventable cancers and a large proportion of cancer patients are obese, but little is understood about how obesity influences the effectiveness of cancer therapy. Clinical studies as well as our pre-clinical data show that obese cancer patients are more resistant to radiotherapy and have higher rates of cancer recurrence. Based on our previous data showing that obesity profoundly impacts tumor biology we will examine mechanisms inducing radiotherapy resistance and how to improve outcomes in obese patients.

PI_NAMEs: MONJAZEB, ARTA MONIR (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Address;adipokines;Adoptive Transfer;Affect;antitumor effect;Apoptotic;BCL2 gene;Biological;cancer cell;cancer infiltrating T cells;Cancer Model;Cancer Patient;cancer recurrence;cancer survival;cancer therapy;Cell Proliferation;Clinical;Clinical Data;Clinical Research;Data;diet-induced obesity;Dose;Effectiveness;exhaustion;Fractionated radiotherapy;Functional disorder;Genes;Hormonal Change;Hormones;Immune;Immune response;Immune system;Immune System Diseases;immunosuppressed;Implant;improved;improved outcome;In Vitro;in vivo;Inflammation;Knowledge;Leptin;Link;Malignant Neoplasms;Mediating;Metabolic;Modeling;mouse model;Mus;Obese Mice;obese patients;Obesity;obesity treatment;Outcome;pandemic disease;Patients;personalized medicine;Phenotype;pre-clinical;preclinical study;Preventable cancer cause;Production;Proliferating;Publishing;radiation delivery;Radiation Physics;radiation resistance;radiation response;Radiation therapy;Recurrence;Regulation;Resistance;response;Signal Transduction;Smoking;survivin;T-Lymphocyte;Testing;therapy outcome;Thinness;Toxic effect;Treatment Efficacy;treatment response;treatment strategy;tumor;Tumor Biology;tumor growth;Tumor Immunity;tumor metabolism;tumor microenvironment;United States;Up-Regulation

PROJECT_TITLE: The Impact of Obesity on Radiotherapy Anti-Tumor Effects

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Genetics;Liver Disease;Nutrition;Obesity

PHR: Project Narrative Excessive fat is a hallmark of obesity and a driving force for diabetes and fatty liver disease. This project will delineate a new RNA-based mechanism responsible for excessive fat growth and dysfunction. The outcomes are expected to identify RNA modifiers as new therapeutic targets for the treatments of obesity, type 2 diabetes, fatty liver disease.

PI_NAMEs: RUI, LIANGYOU  (contact)

PROJECT_TERMS: adenovirus mediated delivery;Adipocytes;adipokines;adiponectin;Adipose tissue;Adrenergic Agents;Binding;Brown Fat;Catalytic Domain;cell behavior;Cells;Complex;Development;Diabetes Mellitus;diet-induced obesity;driving force;Embryo;epitranscriptomics;Exercise;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;Functional disorder;gain of function;Gene Expression Profiling;Gene Proteins;Genetic;Genetic Transcription;glucose metabolism;Glycerol;Growth;High Fat Diet;Hormones;Impairment;improved;Insulin;Insulin Resistance;insulin signaling;Knockout Mice;Life;Life Cycle Stages;Link;Lipase;Lipolysis;Liver;Mediating;Messenger RNA;Metabolic;Metabolic Diseases;Metabolism;Methylation;Methyltransferase;Modeling;Modification;Monoacylglycerol Lipases;mRNA Decay;mRNA Precursor;Mus;mutant;Neonatal Mortality;new therapeutic target;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;Nuclear Export;Obesity;Obesity associated disease;obesity treatment;obesogenic;Outcome;overexpression;Pathway interactions;PIK3CG gene;Post-Translational Protein Processing;posttranscriptional;Process;Protein Biosynthesis;Protein Family;Proteins;Reaction;Reader;Research;Resistance;RNA;RNA Binding;RNA methylation;RNA Splicing;Role;Signal Transduction;Starvation;Sympathetic Nervous System;System;Testing;Tissue Expansion;Tissues;trafficking;Transcript;Translations;Triglycerides

PROJECT_TITLE: Role of adipose mRNA modifications in metabolic disease

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Prevention;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE In previous studies with adolescent girls and young women (AGYW) at risk of HIV in sub-Saharan Africa, 20- 50% have symptoms of common mental disorders (e.g., depression, anxiety, stress) which are associated with suboptimal adherence to HIV pre-exposure prophylaxis (PrEP), a highly effective HIV prevention approach. In this K99/R00 project, the candidate, an epidemiologist and behavioral scientist committed to HIV and global mental health research, seeks to address poor PrEP adherence and mental health among AGYW at risk of HIV by adapting, testing, and optimizing an evidence-based mental health intervention for the context of PrEP delivery. This study will provide important insights on approaches for integrating mental health interventions in PrEP delivery and the optimized intervention has the potential to improve both PrEP adherence and mental health outcomes for AGYW in South Africa and other high burden settings.

PI_NAMEs: VELLOZA, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Accounting;Address;Adherence;adolescent health outcomes;Africa South of the Sahara;African;African Women;Age;AIDS prevention;Anxiety;Award;Behavioral;Behavioral Sciences;career;Characteristics;Clinic;common symptom;community advisory board;Complex;Consolidated Framework for Implementation Research;coping;cost;Counseling;Data;design;Development;Discrimination;Educational workshop;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;empowerment;Ensure;Epidemiologist;Epidemiology;evidence base;experience;Face;Feedback;Female Adolescents;Friendships;gender-based violence;Goals;Health;health care delivery;Healthcare;High Risk Woman;HIV;human centered design;Human immunodeficiency virus test;hybrid type 2 trial;implementation barriers;implementation cost;implementation science;implementation strategy;improved;Incidence;Individual;innovation;insight;Intervention;intervention effect;Interview;Link;Manuals;Measures;meetings;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentors;multidisciplinary;Outcome;Perception;persistent symptom;Persons;Pharmaceutical Preparations;Population;Postdoctoral Fellow;pre-exposure prophylaxis;preference;Prevention approach;prevention service;problem solving therapy;Process;programs;prototype;psychologic;Publishing;Randomized;Recommendation;Reproductive Health;Research;Research Personnel;scale up;Scientist;service delivery;Services;social stigma;South Africa;South African;Specific qualifier value;standard of care;Stress;Surveys;Symptoms;Testing;Therapeutic Intervention;therapy design;tool;Training;treatment adherence;treatment arm;Universities;Washington;Work;young woman;Youth;Zimbabwe

PROJECT_TITLE: Adaptation and optimization of the Friendship Bench mental health intervention for adolescent girls and young women in South African PrEP delivery settings

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Breast Cancer;Cancer;Digestive Diseases;Estrogen;Genetics;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases;Women's Health Research

PHR: Project Narrative ERα-positive cancers remain a major clinical need and proposed herein (F99) we seek to explore novel derivatives of ErSO, our newly discovered cytotoxic drug for the treatment of ERα-positive breast cancers. Further, hepatocellular carcinoma is a highly lethal cancer type with a major breakthrough for disease management yet to be elucidated. This proposal (K00) seeks to address this clinical need via study of the mutant allele imbalance (MAI) of CTNNB1 oncogenic mutations, studying this imbalance on tumor metabolism, and ultimately provide insights into CTNNB1 MAI with implications for targeted therapies for hepatocellular carcinoma.

PI_NAMEs: BOUDREAU, MATTHEW W (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Accounting;addiction;Address;Alleles;Allelic Imbalance;anti-cancer;Aromatase Inhibitors;beta catenin;Biological;Biological Availability;Biological Models;blood-brain barrier penetration;bone;Brain;Cancer Biology;cancer cell;cancer therapy;cancer type;career;Cell Death;Cell Line;Cell Reprogramming;Cells;Classification;Clinic;Clinical;clinical development;Clinical Oncology;Clinical Trials;Coin;Complex;complex data;CTNNB1 gene;Cytostatics;cytotoxic;Cytotoxic agent;Data;Data Set;Development;Disease;Disease Management;Disease Resistance;Doxycycline;driver mutation;drug discovery;Drug Kinetics;ESR1 gene;Estrogens;Evaluation;experience;experimental study;gain of function;Generations;genomic data;Growth;Heterozygote;in vivo;Incidence;insight;Investigation;Licensing;Link;Lung;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant Neoplasms;Mammary Neoplasms;Measures;Mediating;Metabolism;metabolomics;Metastatic breast cancer;Metastatic malignant neoplasm to brain;Modality;Modeling;mortality;mouse model;mutant;Mutation;Neoplasm Metastasis;neurotoxicity;Nitrogen;Normal Cell;Normal tissue morphology;novel;Oncogenes;Oncogenic;Oral;overexpression;Pathway interactions;Patients;Penetrance;Pharmaceutical Chemistry;Pharmacodynamics;Pharmacotherapy;Phase;Phase I Clinical Trials;Positioning Attribute;Primary carcinoma of the liver cells;Property;Proteins;Proteomics;Resistance;resistance mechanism;response;Sampling;Selective Estrogen Receptor Modulators;Signal Transduction;skills;small molecule;success;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;Toxic effect;Training;translational potential;trial planning;tumor;tumor eradication;tumor growth;tumor metabolism;Work

PROJECT_TITLE: Targeting Oncogenic Drivers in Cancer


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: In all organ systems, efficient clearance of senescent, damaged, dead and infected cells is necessary for tissue homeostasis and immunosurveillance against viral infections. Understanding this process at a deeper molecular level may reveal novel therapeutic strategies for many age-related and infectious diseases. This application breaks new ground by defining the regulation and function of ion channel TRPM7 in this process and may therefore advance TRPM7 as a novel drug target to modify immunity and tissue regeneration.

PI_NAMEs: DESAI, BIMAL N. (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: age-related disease;Antibodies;Antigen Presentation Pathway;antiviral immunity;Apoptotic;Architecture;Biochemical;Biological Assay;Biological Process;Biophysics;Body System;Cathepsins;Cell Nucleus;Cell Physiology;Cells;Communicable Diseases;Complement;Data;design;Disease;Drug Targeting;Eating;endonuclease;experimental study;Foundations;Genes;Heart;Homeostasis;immune activation;Immune system;Immunity;Immunologic Surveillance;Immunologics;in vivo;Inflammation;Inflammatory;innovation;insight;Investigation;Ion Channel;Lead;Lysosomes;Macrophage;Mediating;Membrane;Membrane Fusion;Modeling;Molecular;Mus;NADPH Oxidase;Nature;Necrosis;new therapeutic target;novel;novel therapeutic intervention;Output;pathogen;Phagocytes;Phagocytosis;Phagolysosome;Phagosomes;Phosphatidylserines;Phosphotransferases;Physiological;Play;Population;prevent;Process;Proteins;Reagent;Regulation;Research;restraint;Role;Secretory Vesicles;senescence;Signal Transduction;Small Interfering RNA;Techniques;Testing;tissue regeneration;Tissues;trafficking;Transgenic Organisms;vacuolar H+-ATPase;Vesicle;Viral;Virus;Virus Diseases;Vision;wound healing

PROJECT_TITLE: TRPM7 at the Crossroads of Tissue Homeostasis and inflammation

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE . The goal of this project is to establish the molecular mechanisms regulating the expression of key components in the signaling of the cardiac natriuretic peptides ANP and BNP in adipocytes and adipose tissue: in particular the transcriptional regulation of the genes encoding natriuretic peptide receptor-C (Nprc), the cGMP-specific phosphodiesterase-9 (Pde9), and the NP-degrading enzyme neprilysin (Mme). We will also test the hypothesis that the elevated NPRC expression in adipose tissue in obesity results in excessive uptake of the peptides ANP and BNP from the circulation and (iii) and to test in mouse models the efficacy and utility of a longer-acting ANP analogue to increase brown/beige adipocyte amount and activity, thus raising energy expenditure and protecting from obesity-induced insulin.

PI_NAMEs: COLLINS, SHEILA  (contact)

PROJECT_TERMS: Adipocytes;Adipose tissue;Adult;Agonist;Atrial Natriuretic Factor;beta-adrenergic receptor;Binding;Body Composition;Body fat;Body Temperature;Body Weight;Brain natriuretic peptide;Brown Fat;Calories;Cardiac;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Catecholamines;Cells;cGMP production;Chronic;Circulation;Clinical Research;cold temperature;Consumption;Critical Pathways;Cyclic AMP;Cyclic GMP;Data;Denervation;Disease;economic impact;effective therapy;Elements;Energy Intake;Energy Metabolism;Enzymes;Epidemic;Fasting;Fatty Acids;Fatty Liver;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;genome-wide;Glucose;glucose tolerance;Goals;Health;Healthcare;High Fat Diet;Histology;Homeostasis;Human;improved;in vivo;Incidence;Income;Individual;Infusion procedures;Insulin;Insulin Resistance;insulin sensitivity;Knockout Mice;Knowledge;Ligands;liver inflammation;Mediating;Metabolic;Metabolic Diseases;Metabolism;Mitochondria;MME gene;Molecular;mouse model;Mus;Natriuretic Peptides;Nature;Neprilysin;Non-Insulin-Dependent Diabetes Mellitus;Norepinephrine;novel;obese person;Obesity;Operative Surgical Procedures;Pattern;peptide analog;Peptide Hydrolases;Peptide Receptor;Pharmaceutical Preparations;phosphoric diester hydrolase;Physiological;Plasma;prevent;Process;Production;Productivity;programs;protein expression;Proteins;Protons;Publishing;Quality of life;receptor;receptor expression;recruit;response;Risk Reduction;Role;saluretic;Signal Pathway;Signal Transduction;Sympathetic Nervous System;Syndrome;System;Temperature;Testing;Thermogenesis;Thinness;Tissues;Transcriptional Regulation;Triglycerides;uncoupling protein 1;uptake;Work

PROJECT_TITLE: Natriuretic peptide and cGMP signaling in adipose tissue and energy metabolism

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE  The main aims of this study are to: 1) Determine the extent that Smad2/3 activation contributes to myopia progression, structural changes indicative of pathological myopia (PM), and retinal degeneration in mouse models of Marfan syndrome (MFS) and Rbp3-mediated retinitis pigmentosa (RP); 2) Determine a role for TGFβ- dependent mitogen-activated protein kinase (MAPK) signaling in myopia progression, PM changes and retinal degeneration in MFS and Rbp3-deficient mice. The scientific goal of this proposal is to elucidate the mechanisms driving excess eye growth, its structural complications, and concomitant retinal degeneration in two etiologically- distinct causes of monogenic myopia to identify and target common drivers of disease progression.

PI_NAMEs: DOYLE, JEFFERSON JAMES (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Aorta;Automobile Driving;autosome;Biochemical;Biometry;bone;Ciliary Body;Clinical;Communication;Connective Tissue Diseases;Data;Degenerative Myopia;Disease Progression;E2F transcription factors;Educational workshop;efficacious treatment;Electroretinography;Etiology;experience;Eye;Funding;Fundus photography;Future;Gene Expression;Genetic Diseases;Goals;Growth;Histologic;Human;Immunofluorescence Immunologic;in vivo;Individual;Inherited;inhibitor;K-Series Research Career Programs;Knowledge;Laboratories;Leadership;Length;loss of function mutation;Lung;MAPK3 gene;Marfan Syndrome;Mediating;meetings;Mendelian disorder;Mentors;Mentorship;Mitogen-Activated Protein Kinases;Modeling;Molecular;mouse model;Mus;Muscle;Myopia;new therapeutic target;novel therapeutic intervention;Optical Coherence Tomography;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathway interactions;Patients;Phenotype;Photoreceptors;programs;Research;Research Activity;response;responsible research conduct;Retina;Retinal Degeneration;Retinal Detachment;Retinal Dystrophy;Retinitis Pigmentosa;Retinoschisis;Review Literature;Risk;Role;Scientist;side effect;Signal Transduction;skills;Techniques;Testing;Therapeutic;Thinness;Training;Transforming Growth Factor beta;Vision;Visual impairment;Western Blotting;Writing

PROJECT_TITLE: Elucidation of the Molecular Mechanisms Driving Genetically-Induced High Myopia


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Nutrition

ORG_CITY: LA JOLLA

PHR: PROJECT NARRATIVE Interventions such as fasting that lower food intake have long been known to extend lifespan. This application shows that increasing energy expenditure rather than lowering food intake, an intervention we call reverse fasting, also increases lifespan even in animals that eat more than ad libitum fed animals. Our result strongly argues against the view that damage from energy metabolism is a significant driver of aging.

PI_NAMEs: PETRASCHECK, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Aging;Animal Feed;Animals;Caenorhabditis elegans;Candidate Disease Gene;CD2 Antigens;Cyclic AMP;Diet;Dose;drivers of aging;Eating;empowerment;Energy consumption;Energy Intake;Energy Metabolism;Energy Supply;Equilibrium;experimental study;extend lifespan;Fasting;Fatigue;feeding;follow-up;Future;G-Protein-Coupled Receptors;Gene Expression;Generations;Genes;Health;Hyperphagia;Insulin;Intake;Intervention;knock-down;Link;Longevity;Measures;Mediating;Metabolic;Mitochondria;Modeling;mutant;Pathway interactions;Phenotype;Predisposition;prevent;reduced food intake;Respiration;response;RNA Interference;Serotonin;serotonin receptor;Signal Transduction;Starvation;Testing;Time;trigger point

PROJECT_TITLE: Lifespan extension by reverse fasting


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative The proposed research is relevant to public health because it rooted in the social ecological model framework, which considers the myriad levels of our healthcare system in the quantitative and qualitative evaluation of social factors, facilitators and barriers, and surgical outcomes for patients with limited English proficiency (LEP). With the findings of this research and the evaluation of a mobile medical interpretation application deployed to patients with LEP, we have the potential to design and implement future scalable interventions built with patient-centered communication and mitigating negative social factors at the core across hospitals across the US for maximum impact. Thus, the proposed research is relevant to the NIMHD’s mission as it aims to reduce health inequities and improve the care of millions of patients by mitigating language and communication barriers.

PI_NAMEs: ORTEGA, GEZZER  (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Acceleration;Address;Adverse event;adverse event risk;Affect;Award;Bypass;career;Caring;Certification;Clinical;cohort;Communication;Communication Barriers;Communities;Complex;Complication;Continuity of Patient Care;Data;data registry;design;direct application;Discipline;Disparity;Emergency Situation;empowerment;Equity;Evaluation;experience;Family;Funding;Future;Gestures;Goals;Health;health data;health disparity;health inequalities;health information technology;health outcome disparity;Healthcare;Healthcare Systems;high risk;Home;hospital readmission;Hospitals;implementation science;improved;improved outcome;Individual;Inequity;innovation;Institution;Institutional Racism;Intervention;Interview;Language;Legal;Length of Stay;Limited English Proficiency;Link;Medical;Medicine;Mentors;Mission;mobile application;mobile computing;Modeling;National Institute on Minority Health and Health Disparities;nonEnglish language;Nurses;Operative Surgical Procedures;Outcome;Participant;Patient Care;patient oriented;patient population;Patient-Centered Care;patient-clinician communication;Patient-Focused Outcomes;Patients;Persons;Physicians;Play;Policies;Provider;Public Health;Qualifying;Qualitative Evaluations;Qualitative Research;Quantitative Evaluations;readmission rates;Research;Research Methodology;Resources;Risk Factors;Scientist;Services;skills;social;social factors;social health determinants;sociodemographic factors;socioeconomics;Spanish;Structure;Surgeon;surgery outcome;surgical disparities;Surgical Specialties;technology intervention;Testing;therapy design;Training;Translations;United States;United States National Institutes of Health;Vulnerable Populations

PROJECT_TITLE: Improving Outcomes for Spanish-Speaking Surgical Patients with Limited English Proficiency


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Rates of alcohol use disorders (AUD) in women have increased by 84% over the past 10 years. All FDA- approved medications for AUD have relatively low efficacy and none target factors that maintain drinking in women. This research will contribute to the public health effort to improve AUD treatment by providing a neurobiologically-informed approach to the development of sex-appropriate therapeutics for AUD, mentoring the next generation of interdisciplinary and translational researchers focused on alcohol use and women’s health, and providing an institutional, regional, and national center of research excellence on sex differences in alcohol use spanning T1 to T4 translation.

PI_NAMEs: MCKEE, SHERRY ANN (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Accounting;addiction;Address;Affect;alcohol abuse therapy;Alcohol consumption;alcohol use disorder;Alcohols;Area;Award;Basic Science;Behavioral;behavioral pharmacology;Biology;Biomedical Research;Brain;Cardiovascular Diseases;Centers of Research Excellence;cerebral atrophy;Clinical Sciences;Cognitive deficits;Collaborations;Communities;Consultations;Darkness;Data;Development;drinking;economic cost;Ensure;Environment;Ethanol Metabolism;experience;Faculty;faculty support;FDA approved;Funding;Goals;Gonadal Steroid Hormones;Health;Healthcare;heuristics;hypothalamic-pituitary-adrenal axis;improved;Infrastructure;Institution;interest;Laboratories;Leadership;liver inflammation;Malignant Neoplasms;men;Mentors;metabolomics;Modeling;Morbidity - disease rate;mortality;National Institute on Alcohol Abuse and Alcoholism;negative affect;Negative Reinforcements;neuroadaptation;Neurobiology;neurochemistry;Neuroimmune;Neurosciences;neurotoxicity;next generation;novel therapeutics;outreach;outreach program;Pharmaceutical Preparations;Policies;Positive Reinforcements;Positron-Emission Tomography;programs;Psychiatry;Public Health;Publications;recruit;Research;Research Personnel;Research Priority;Resources;response;Rewards;Risk;Role;Sampling;sex;sex as a biological variable;Sex Differences;Side;Specialized Center;Stress;Structure;Substance abuse problem;success;System;Teacher Professional Development;Therapeutic;therapeutic target;Translating;translational approach;translational pipeline;Translational Research;translational scientist;Translations;treatment response;United States;Withdrawal;Woman;Women's Health

PROJECT_TITLE: YALE-SCORE ON SEX DIFFERENCES IN ALCOHOL USE DISORDER


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Substance Misuse;Women's Health Research

PHR: Rates of alcohol use disorders (AUD) in women have increased by 84% over the past 10 years. All FDA- approved medications for AUD have relatively low efficacy and none target factors that maintain drinking in women. The Leadership Administrative Core will advance the public health effort to improve AUD treatment by providing key infrastructure to support an integrated scientific environment focused on the development of sex- appropriate treatments for AUD.

PROJECT_TERMS: addiction;Advanced Development;alcohol abuse therapy;Alcohol consumption;alcohol use disorder;Award;Biosensor;career;Clinical Research;Collection;Communities;Consultations;Darkness;Data;Data Collection;design;Development;Doctor of Philosophy;drinking;Education;Education and Outreach;Ensure;Environment;faculty support;FDA approved;Funding;gender difference;Goals;Health Personnel;Human Resources;improved;Infrastructure;Institution;Lead;Leadership;meetings;Mentorship;Office of Administrative Management;outreach;Pharmaceutical Preparations;Pilot Projects;Policies;preclinical study;Principal Investigator;Public Health;Research;Research Personnel;Resources;Role;sex;Sex Differences;Side;Structure;synergism;Teacher Professional Development;Therapeutic;Training;Translating;translational pipeline;translational potential;Translations;Woman;Work

PROJECT_TITLE: Leadership Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMNR-A]


ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Colorectal cancer is the 2nd most common cause of cancer death among men and women in the Unites States, with a majority of the mortality associated with metastasis that has spread to other organs. We have proposed to investigate the mechanisms of how lipid metabolism promotes CRC metastasis. The completion of this study will help to advance our knowledge of the contribution of lipid metabolism to CRC metastasis and to further guide the development of novel therapeutic strategies to treat CRC and potentially other solid cancers.

PI_NAMEs: ZAYTSEVA, YEKATERINA  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: analog;Biological;Biological Assay;Biological Sciences;cancer cell;Cancer Etiology;Cancer Patient;Cause of Death;CD36 gene;Cecum;Cell Survival;Cessation of life;Clinical;Clinical Trials;Collaborations;Colorectal Cancer;colorectal cancer metastasis;colorectal cancer progression;Compensation;Data;Development;Disease;Drug Evaluation;Drug Targeting;Environment;Enzymes;fatty acid metabolism;Fatty Acids;Fatty-acid synthase;Gene Modified;genetic approach;Goals;Growth;high risk;Human;In Vitro;in vivo;in vivo Model;Incidence;inhibitor;Injections;Knowledge;lipid biosynthesis;lipid metabolism;Lipids;Literature;Malignant Neoplasms;Mediating;men;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Metastatic Neoplasm to the Liver;Metastatic Neoplasm to the Lung;Microarray Analysis;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Neoplasm Metastasis;neutralizing antibody;new therapeutic target;novel;novel therapeutic intervention;Oncology;Organ;Organoids;Outcome;overexpression;Palmitates;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Phase;Phase I/II Clinical Trial;Phase II Clinical Trials;Pre-Clinical Model;preclinical study;prevent;Prognosis;Public Health;Recurrent disease;Regulation;Research;resistance mechanism;response;Role;Sampling;Signal Pathway;Solid;Solid Neoplasm;Specimen;Sphingolipids;Sphingosine;sphingosine 1-phosphate;sphingosine kinase;stable isotope;targeted treatment;Testing;Therapeutic;therapeutic target;Tissue Microarray;transcriptome sequencing;translational impact;translocase;tumor;Tumor Angiogenesis;tumor metabolism;United States;Up-Regulation;uptake;Validation;Woman

PROJECT_TITLE: Targeting Lipid Metabolism in Colorectal Cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Social Determinants of Health;Substance Misuse;Women's Health Research

PHR: The Career Enhancement Core of the Yale-SCORE contributes to public health by responding to the dramatic need for interdisciplinary and translational scientists, focused on applying sex as a biological variable (SABV) to the study of alcohol use. The Career Enhancement program provides: a team of mentors who are leaders in translational, alcohol, and SABV science, salary support for junior faculty, a pilot project program, and a core curriculum that provides foundational knowledge, professional development and leadership training.

PI_NAMEs: PETRAKIS, ISMENE L. (contact)

PROJECT_TERMS: Alcohol consumption;alcohol research;alcohol use disorder;Alcohols;Award;Behavioral;Biological;career;career development;career life balance;Chairperson;cohort;Collaborations;Communities;Complex;Data;Dedications;Development;Doctor of Philosophy;drinking;early-career faculty;Education;Educational Curriculum;Educational process of instructing;effective therapy;Eligibility Determination;Ensure;Environment;Evaluation;Executive Dysfunction;experience;Faculty;faculty mentor;faculty support;Feedback;Funding;gender difference;Goals;graduate student;Grant;Health;Immune response;Institution;International;Knowledge;Lead;Leadership;leadership development;Learning;Letters;Maintenance;Maps;Mediation;medical schools;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;National Institute on Alcohol Abuse and Alcoholism;neuroadaptation;neurotoxicity;next generation;Peptide Initiation Factors;pharmacokinetics and pharmacodynamics;Phase;Pilot Projects;Policies;Postdoctoral Fellow;Prevention strategy;Process;programs;psychiatric comorbidity;Psychiatry;psychosocial;Public Health;Publications;Publishing;Qualifying;recruit;Research;Research Personnel;Research Project Grants;research study;Research Support;Resources;responsible research conduct;Risk;Risk Factors;Role;Science;Scientist;Series;sex;sex as a biological variable;Sex Differences;skills;sociocultural determinant;stress reactivity;Structure;success;Symptoms;synergism;Time;tool;Training;translational pipeline;Translational Research;translational scientist;treatment strategy;United States National Institutes of Health;Wages;Withdrawal;Woman;Women's Health;Work;Writing

PROJECT_TITLE: Career Enhancement Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Social Determinants of Health;Substance Misuse;Women's Health Research

PHR: Rates of alcohol use disorders (AUDs) in women have increased by 84% over the last decade, relative to the 35% increase in men. The Resource Support Core is addressing public health by supporting the dramatic need for translational research to address the concerning increase in rates of AUD among women. The key purpose of the Resource Support Core is to provide essential research-related resources to Yale-SCORE investigators, trainees, and collaborating researchers.

PI_NAMEs: GUEORGUIEVA, RALITZA  (contact)

PROJECT_TERMS: Address;Alcohol consumption;alcohol use disorder;Animals;behavioral phenotyping;Big Data;Biological Assay;Biosensor;Blood alcohol level measurement;clinical investigation;Clinical Research;Clinical Trials Data Monitoring Committees;Collaborations;Communication;Consultations;craving;cytokine;Data;Data Analytics;data management;data resource;Data Set;demographics;design;digital;Disease;Doctor of Philosophy;drinking;drinking behavior;DSM-V;Ensure;Environment;Ethanol Metabolism;ethnic minority;executive function;Female;Goals;Gonadal Steroid Hormones;Human;human subject;hypothalamic-pituitary-adrenal axis;IACUC;Impulsivity;innovation;Institution;Institutional Review Boards;Investigation;Leadership;Location;male;Medical;meetings;men;Menstrual cycle;Methods;Modernization;Monitor;Moods;Pilot Projects;pre-clinical;Procedures;psychiatric symptom;Public Health;Quality Control;racial minority;Recording of previous events;recruit;Reporting;Reproductive History;Research;Research Personnel;Resources;Safety;Sampling;screening;Sex Differences;social;Stress;System;Techniques;therapy development;Time;Tobacco use;Training;Translational Research;Translations;wearable sensor technology;Woman

PROJECT_TITLE: Resource Support Core


NIH_SPENDING_CATS: Aging;Diabetes;Nutrition;Obesity

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Recruitable thermogenic beige adipocytes have been thought to be short-lived, rapidly converting to “white-like” adipocytes after discontinuing the stimuli. This creates a key challenge to explore beige adipocytes as a sustainable therapy for chronic metabolic diseases. We have recently discovered that beige adipocytes have the ability to stay long-lived and subsequently improve energy expenditure and metabolic fitness. This proposal is designed to leverage our expertise in adipocyte biology and mouse genetics and study the mechanism on how beige adipocytes lose their cellular identity under both physiological and pathological conditions, and how this progress can be maintained to combat obesity and insulin resistance.

PI_NAMEs: JIANG, YUWEI  (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: adipocyte biology;Adipocytes;Adipose tissue;Age;age acceleration;Aging;arm;Autophagocytosis;Biological Markers;CDKN2A gene;Cell Cycle;cell type;Cells;Chronic;combat;Consumption;Cyclin-Dependent Kinases;Data;design;Development;Diabetes Mellitus;diet-induced obesity;Disease;Energy Metabolism;Epidemic;Excision;experimental study;Fatty acid glycerol esters;Genetic;Glucose;Goals;Health;improved;in vivo;inhibitor;insight;Insulin Resistance;insulin sensitivity;Laboratories;life span;Lipids;Longevity;Maintenance;Measures;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic fitness;metabolic phenotype;Molecular;mouse genetics;mouse model;Mus;Nature;new therapeutic target;Non obese;novel;novel strategies;Obesity;old mice;Outcome;p19ARF;Pathologic;Pathway interactions;pharmacologic;Phenocopy;Phenotype;Physiological;preservation;prevent;Process;programs;Proteins;recruit;Regulation;response;Role;senescence;Signal Transduction;Stimulus;System;Testing;Therapeutic;therapeutic target;TP53 gene;transcriptomics;uncoupling protein 1;Work

PROJECT_TITLE: Regulation of beige adipocyte maintenance and its impact on metabolic outcomes


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Substance Misuse;Women's Health Research

PHR: Rates of alcohol use disorders (AUD) in women have increased by 84% in women over the past 10 years. All FDA-approved medications for AUD have relatively low efficacy and none target factors that maintain drinking in women. This research contributes to the public health effort to improve AUD treatment, by establishing whether guanfacine, a selective alpha2a adrenergic agonist, demonstrates efficacy for AUD by preferentially attenuating stress-induced drinking in women and stimulation-induced drinking in men.

PROJECT_TERMS: addiction;Address;Adrenergic Agonists;Adrenergic Receptor;Affect;Agonist;alcohol abuse therapy;Alcohol consumption;alcohol effect;alcohol use disorder;Alcohols;Attenuated;Behavior;Biosensor;Blood alcohol level measurement;Cardiovascular system;Cellular Phone;Clinical;Clinical Trials;Clinical Trials Design;cognitive function;Consumption;Corticotropin;craving;cytokine;Darkness;Data;design;Development;Double-Blind Method;drinking;drinking behavior;Ethanol Metabolism;FDA approved;Feedback;Female;Frequencies;Germ Cells;Gonadal Steroid Hormones;Grant;Guanfacine;Heavy Drinking;heuristics;Human;Hybrids;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Imagery;improved;innovation;Investigation;Laboratories;Location;male;men;Moods;Negative Reinforcements;Neurobiology;neuromechanism;noradrenergic;Norepinephrine;novel;Outcome;Participant;Pharmaceutical Preparations;Phase;Pilot Projects;Placebo Control;Placebos;Positive Reinforcements;Pre-Clinical Model;presynaptic;Property;prospective;Prospective Studies;Public Health;Randomized;Regulation;Relapse;Research;Resources;Rewards;Safety;sex;Sex Differences;Side;social;Stress;stress reactivity;stress reduction;System;Therapeutic;Time;Titrations;treatment duration;Treatment outcome;treatment response;wearable sensor technology;Woman;women versus men

PROJECT_TITLE: PROJECT 1: Targeting stress-reactivity and noradrenergic mechanisms for sex-appropriate alcohol use disorder treatment.


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE  We have discovered through in-depth analysis of unique sets of matched samples from patients before and after carboplatin/paclitaxel treatment, chemosensitive/chemoresistant patient-derived xenograft (PDX) models, and platinum or taxane-resistant cell lines, that chemoresistant ovarian cancer cells have a preferential dependence on ribosomal biogenesis for their survival. Targeting ribosomal biogenesis with inhibitors of RNA Polymerase I (Pol I) are effective in eliminating chemoresistant cells, without damaging noncancerous cells at equivalent doses. This proposal will identify the optimal approach to target chemoresistant ovarian cancer cells with a new class of inhibitors, elucidate the fundamental mechanisms causing chemoresistant cells to be more dependent on ribosomal biogenesis than nonmalignant cells, and identify new targetable genes that can be used combination with Pol I inhibition for enhanced therapeutic effect.

PI_NAMEs: LANDEN, CHARLES NICHOLSON (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Affect;Biogenesis;Biological Products;biomarker identification;cancer cell;Cancer cell line;cancer subtypes;candidate identification;Carboplatin;Cell Line;Cells;Cessation of life;Chemoresistance;chemotherapy;Chromatin Structure;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;combat;combinatorial;CRISPR library;Cytotoxic agent;Data;Dependence;Development;Disease Resistance;DNA;DNA Damage;DNA Polymerase I;Dose;drug candidate;druggable target;efficacy evaluation;Epithelial ovarian cancer;Evolution;Genes;Genetic Transcription;Histology;in vivo;in vivo Model;inhibitor;knock-down;Knock-out;Life;Maintenance Therapy;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Microscopic;Modeling;Molecular;next generation;Non-Malignant;novel;novel strategies;novel therapeutic intervention;Paclitaxel;Pathway interactions;patient derived xenograft model;Patient Selection;Patients;phase I trial;Phase I/II Trial;Phenotype;Platinum;Population;pre-clinical;Predisposition;prevent;Process;Production;Proliferating;promoter;Recurrence;Resistance;response;response biomarker;Ribosomal Biogenesis Pathway;Ribosomal DNA;Ribosomal RNA;ribosome profiling;Ribosomes;RNA Polymerase I;RNA Polymerase Inhibitor;Role;Sampling;Science;screening;side effect;Site;small hairpin RNA;Specificity;synergism;System;taxane;Therapeutic;Therapeutic Effect;TP53 gene;transcriptome;Translating;translatome;treatment response;tumor;Tumor Debulking;Up-Regulation;virtual

PROJECT_TITLE: Targeting RNA Polymerase I Transcription Machinery in Chemoresistant Ovarian Cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Nanotechnology;Orphan Drug;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Pancreatic ductal adenocarcinoma (PDAC) is currently the third most lethal cancer in the United States with poor prognosis in part due to the late-stage diagnosis and treatment. We propose to develop a novel nano- formulation of miRNA that reverts pancreatic cancer at an early stage of cancer development. These nanotherapeutics can be used as a pre-malignant stage treatment or prophylaxis for individuals with high risk of pancreatic cancer.

PI_NAMEs: SCHMITTGEN, THOMAS D.;ZHANG, FAN  (contact)

PROGRAM_OFFICER_NAME: CLIFFORD, JOHN LEO

PROJECT_TERMS: 3' Untranslated Regions;3-Dimensional;Acinar Cell;Acinus organ component;Acute;acute pancreatitis;Age;arm;Attenuated;Binding Sites;Biodistribution;Biological Assay;Biological Markers;Blood;Body Temperature Changes;Body Weight;Caerulein;cancer initiation;cancer therapy;Cell Line;Cell surface;Cessation of life;Chemotherapy and/or radiation;Chronic;Clinic;Clinical;Colorectal Cancer;Data;Death Rate;Dendrimers;Development;Diagnosis;Disease;Dose;Duct (organ) structure;Early Diagnosis;Early treatment;effective therapy;efficacy study;Engineering;Epigenetic Process;Epithelium;Event;Formulation;Genes;Glycoproteins;high risk;Histology;immunogenicity;Immunotherapy;improved;In Vitro;in vivo evaluation;Incidence;Individual;Intraepithelial Neoplasia;Knockout Mice;KPC model;KRASG12D;Lesion;Libraries;lipid nanoparticle;Luc Gene;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Maximum Tolerated Dose;Mesenchymal;Metaplasia;Methods;microRNA delivery;MicroRNAs;Mus;nanoformulation;nanoparticle;nanoparticle delivery;nanotherapeutic;new therapeutic target;novel;Oligonucleotides;Operative Surgical Procedures;Outcome;Pancreas;Pancreatic Ductal Adenocarcinoma;Pancreatic Intraepithelial Neoplasia;Patients;premalignant;Process;Prognosis;Prophylactic treatment;Publishing;Quantitative Reverse Transcriptase PCR;Repression;restoration;Role;screening;Testing;Therapeutic;Toxic effect;Transfection;Treatment Effectiveness;tumor;Tumor Suppression;tumorigenesis;United States;Untranslated RNA;vector

PROJECT_TITLE: R21 MPI microRNA directed therapy for treating early stage pancreatic cancer


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Neurodegenerative;Neurosciences;Substance Misuse;Women's Health Research

PHR: In the United States, approximately 33 million men and women have an alcohol use disorder (AUD) and their alcohol use has devastating consequences on their health and mental well-being, with women suffering greater consequences than men. Current treatments for AUD show only minimal efficacy. This research contributes to the public health effort by identifying neurochemical mechanisms, including microglia and synaptic density, that underlie the sex differences in alcohol-related dysfunction, informing novel sex-appropriate therapeutic approaches.

PI_NAMEs: COSGROVE, KELLY P. (contact)

PROJECT_TERMS: Abstinence;addiction;Admission activity;Affinity;Age;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol effect;alcohol use disorder;Alcohols;Behavioral;Binding;Biological Markers;Brain;Brain imaging;Cardiovascular system;Cells;Cerebellum;cerebral atrophy;Chronic;chronic alcohol ingestion;Clinical;Clinical Trials;Consumption;Country;craving;Darkness;Data;density;Development;drinking;drinking behavior;Ensure;Environment;Ethanol Metabolism;Exhibits;Functional disorder;Glycoproteins;Gonadal Steroid Hormones;gray matter;Guanfacine;Health;Hippocampus;Human;hypothalamic-pituitary-adrenal axis;Image;imaging biomarker;Imaging Device;Imaging Techniques;Immune;Immune System Diseases;Impaired cognition;Impairment;Individual;Interruption;Laboratories;Link;Measures;men;men's group;Microglia;molecular marker;Moods;negative affect;Negative Reinforcements;Nerve Degeneration;neuroadaptation;neurochemistry;Neurocognitive;neuroimaging;Neuroimmune;Neuroimmune system;novel;Outcome;Outer Mitochondrial Membrane;Outpatients;Participant;Pathologic Processes;Patients;Peripheral;Pharmaceutical Preparations;Phase;Physiological Processes;Placebos;Positive Reinforcements;Positron-Emission Tomography;preclinical study;presynaptic;Property;Proteins;Public Health;radiotracer;repair function;Reporting;Research;Rewards;Scanning;sex;Sex Differences;sex variable;Side;Signal Transduction;Stress;stress reactivity;Structure;Surveys;Synapses;Synaptic Vesicles;synergism;System;Technology;theories;Therapeutic;Time;tool;Treatment outcome;United States;Well in self;Woman

PROJECT_TITLE: PROJECT 2: Imaging sex differences in stress-related neurochemical mechanisms of alcohol use disorders


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Income volatility, i.e., fluctuations in income over time, creates uncertainty for low socioeconomic status families of whether they will have enough money to make ends meet, which may cause anxiety, worry, and stress. Chronic stress may in turn accelerate aging. This project will investigate the association between income volatility and anxiety, worry, and stress and the association between income volatility and physiological aging.

PI_NAMEs: CARVALHO, LEANDRO SIQUEIRA (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Acceleration;Advisory Committees;Affect;age acceleration;age related;Aging;allostatic load;American;Anxiety;Area;Award;Biological Aging;Biological Markers;Biological Process;Buffers;Cardiovascular Diseases;cardiovascular disorder risk;career;career development;Cell Aging;Characteristics;Chronic;Chronic stress;college;coping;Data;Data Aggregation;Deaths of despair;Dementia;Economics;Evaluation;Event;experience;Face;Family;Financial Hardship;food insecurity;Future;Goals;Health;health disparity;Health Expenditures;Impaired cognition;Income;Individual;Life;Link;low socioeconomic status;Measures;men;Mental Depression;Mental Health;Mentors;Metabolic Diseases;mortality;Not Hispanic or Latino;Personal Satisfaction;Physiological;Population;Populations at Risk;Proxy;Research;Research Personnel;Resources;Risk;Savings;Schedule;Scientist;skills;social;Socioeconomic Status;Source;Stress;study population;Surveys;Time;Training;Trust;Uncertainty;Volatilization;Weather;Work

PROJECT_TITLE: Shaky Income, Rising Angst? Income Volatility, Psychological Health, and Biological Aging

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Neurosciences;Substance Misuse;Women's Health Research

PHR: Women are more likely to drink in response to stress than men. Project 3 will study mechanisms for sex differences in negative reinforcement drinking to be studied in Projects 1 and 2 to help provide new targets for the treatment of problem drinking. We will contribute to the public health by investigating sex differences in nerve cell function, neuroimmune signaling, and metabolism that respond to alcohol and stress, and determine whether these factors can be targeted to develop sex-appropriate treatments for alcohol use disorders.

PI_NAMEs: PICCIOTTO, MARINA R (contact)

PROJECT_TERMS: Acute;addiction;Affect;Agonist;Alcohol abuse;alcohol abuse therapy;alcohol behavior;Alcohol consumption;alcohol effect;alcohol exposure;alcohol relapse;alcohol use disorder;Alcohols;allostasis;Amygdaloid structure;Animal Model;Anti-Anxiety Agents;anti-depressive agents;Anxiety;anxiety-related behavior;Area;Behavior;Behavioral;biological adaptation to stress;Brain;brain metabolism;Brain Stem;catalase;cell injury;Cell Physiology;Chronic;chronic alcohol ingestion;Consumption;Darkness;Data;density;Dependence;depressive symptoms;Development;drinking;endophenotype;Enzymes;Equilibrium;Ethanol;Ethanol Metabolism;experience;Female;GABA Agents;GABA-A Receptor;gamma-Aminobutyric Acid;glial activation;Grant;Guanfacine;Hippocampus;Human;Hyperactivity;hypothalamic-pituitary-adrenal axis;Inflammation;Intervention;Knock-out;Maintenance;male;Measures;Mediating;men;Metabolism;Microglia;Modeling;Molecular;Molecular Genetics;Mus;negative affect;Negative Reinforcements;nerve injury;neural;neuroadaptation;neurobiological mechanism;Neurobiology;neurochemistry;Neuroimmune;neuroinflammation;Neuromodulator;neuronal patterning;Neurons;neurotransmission;Neurotransmitters;noradrenergic;Norepinephrine;Norepinephrine Receptors;novel;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pilot Projects;postsynaptic;preclinical study;Predisposition;preference;Prefrontal Cortex;presynaptic;Public Health;Publishing;receptor;Relapse;response;restraint stress;Rodent;Role;sex;Sex Differences;sexual dimorphism;Side;Signal Pathway;Signal Transduction;Stress;stress reactivity;Structure;Synapses;synaptic pruning;System;Therapeutic;Time;Translating;varenicline;Woman;women versus men

PROJECT_TITLE: PROJECT 3: Neurobiological basis of negative-reinforcement drinking in female and male mice


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Depression;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative__ ______________________________________________________________________ Family caregivers to persons living with Alzheimer’s disease and related dementias provide complex care tasks (e.g., medication management, pain management, and mobility assistance) with no training, resulting in a lack confidence when performing complex care tasks and an increased likelihood of experiencing experience emotional difficulty. Learning Skills Together is a psychoeducational skills-based intervention developed by a multidisciplinary team of healthcare experts to improve caregivers’ self-efficacy with the performance of complex care tasks and to reduce their emotional distress. We propose to test caregiver participation in the Learning Skills Together program in a randomized controlled trial and compare its effects on caregiver self-efficacy with an active control group.

PI_NAMEs: MEYER, KYLIE NICOLE (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: active control group;Active Learning;Address;Adult;Affect;African American;Aging;Alzheimer's Disease;Alzheimer's disease caregiver;Alzheimer's disease related dementia;Area;arm;Awareness;Beds;Behavior Therapy;Behavioral Model;Behavioral Symptoms;Belief;Black race;care outcomes;care recipients;caregiver depression;caregiver interventions;Caregivers;caregiving;Caring;Characteristics;Cognitive;cognitive change;Communication;Communities;community setting;comparative efficacy;Complex;Control Groups;Deglutition;Deglutition Disorders;Dementia;dementia care;Dementia caregivers;dementia caregiving;Dental Hygiene;depressive symptoms;design;Discipline of Nursing;Disease;Educational Intervention;Educational process of instructing;effectiveness evaluation;efficacy testing;emotional distress;emotional experience;Ethnic Origin;evidence base;experience;Family;Family Caregiver;Feedback;feeding;Gait;Gender;Gerontology;glucose monitor;Goals;group intervention;Health;Health education;Health Professional;Healthcare;improved;Intervention;intervention effect;Knowledge;Latinx;Learning Skill;Mediator;Medical;Medical Care Team;Medication Management;Mental Depression;Methods;Modeling;monitoring device;multidisciplinary;multiple chronic conditions;National Institute on Aging;nutrition;Occupational Therapy;older adult;online delivery;Outcome;Pain management;Participant;peer learning;Perception;Performance;Personal Satisfaction;Persons;Pilot Projects;pilot test;Population;post intervention;preservation;Problem Solving;programs;psychoeducation;psychoeducational intervention;psychological symptom;Race;Randomized;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Resistance;Resources;response;Risk;secondary outcome;Self Care;Self Efficacy;skills;Speech-Language Pathology;Structure;Subgroup;symposium;Testing;theories;Training;Treatment Efficacy;United States National Institutes of Health;videoconference;Videoconferencing;Well in self;Woman

PROJECT_TITLE: Learning Skills Together: A Randomized Controlled Trial of a Complex Care Skills Intervention to Improve AD/ADRD Caregiver Self-Efficacy

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Lung;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE  Metastatic disease, the most common cause of breast cancer-related mortality, is mediated by cancer cells capable of disseminating and colonizing distant organs. We will determine the signaling events within tumor microenvironment required for emergence of disseminating cancer cell phenotype (invasive and stem). We will also determine the mechanisms by which these cancer cells re-disseminate from metastatic foci, a process that may perpetuate metastases even after the removal of the primary tumor. Since the majority of patients with metastases are treated with chemotherapy we will determine the effect of chemotherapy on these two processes.  To capture the true biology of the tumor microenvironment we will employ novel technologies for in vivo imaging of large volumes of tissue along with our novel biosensors, both in primary tumors and in the lungs, with single cell resolution, and over many days. The findings will likely lead to new approaches for treatment of metastatic disease which is responsible for 90 percent of cancer related mortality.

PI_NAMEs: CONDEELIS, JOHN S;ENTENBERG, DAVID ;OKTAY, MAJA HRZENJAK (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Actins;Anatomy;Biosensor;Blood capillaries;Blood Vessels;cancer cell;carcinogenesis;Cells;Chemoresistance;chemotherapy;Circulation;curative treatments;Data;density;Diagnosis;Disease;Disseminated Malignant Neoplasm;Distant;Distant Metastasis;Endothelial Cells;Event;Excision;Extravasation;Future;genetic regulatory protein;Immunofluorescence Immunologic;improved outcome;in vivo;in vivo imaging;insight;Kinetics;Life;Light;Lung;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Metastasis Induction;Metastatic breast cancer;Metastatic Neoplasm to the Lung;Microanatomy;Modeling;Molecular;Molecular Target;mortality;Neoplasm Metastasis;neoplastic cell;new technology;NF-kappa B;notch protein;novel;novel therapeutic intervention;Organ;Patient-Focused Outcomes;Patients;Phenotype;Population;Primary Neoplasm;Process;programs;Protein Isoforms;Publishing;Resolution;Signal Transduction;Site;stem;stem cells;stemness;Techniques;Time;Tissues;transcription factor;tumor;Tumor Biology;tumor growth;tumor initiation;tumor microenvironment;Tumor-associated macrophages;Woman

PROJECT_TITLE: THE EFFECT OF TUMOR MICROENVIRONMENT ON METASTASIS

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Narrative TET enzymes remove DNA methylation and their activity is often lost or diminished in many different cancers, including B cell lymphomas. Why loss-of TET function causes development of cancers remains unclear. This proposal will investigate mechanisms by TET proteins prevent the accumulation of unusual structures in the DNA, called G-quadruplexes, which cause genomic instability and transcriptional perturbations; that are hallmarks of cancer cells. These studies will be pivotal in understanding how TET proteins suppress development of cancers and will pave way for new therapeutic regimens for treatment of B-cell and other malignancies.

PI_NAMEs: SHUKLA, VIPUL  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acute;ARID1A gene;ATRX gene;B lymphoid malignancy;B-Cell Lymphomas;B-Lymphocytes;Binding Proteins;Biological Models;Biological Process;cancer cell;cell growth;Cell Physiology;Cells;cellular development;ChIP-seq;Chromatin;Chromatin Structure;clinically significant;cohort;comparison control;Complex;Cytosine;demethylation;Deposition;Development;Dioxygenases;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Methylation;DNA Polymerase II;DNA Structure;DNA-Directed DNA Polymerase;DNA-Directed RNA Polymerase;Environment;Enzymes;ERCC3 gene;Evaluation;Family;G-Quartets;Gamma-H2AX;Gene Expression;Genetic Transcription;Genome;genome integrity;Genome Mappings;genome-wide;Genomic Instability;Genomic Segment;Genomics;Government;helicase;Hematologic Neoplasms;Hematology;Histones;Human;humoral immunity deficiency;Hypoxia;Immunization;infancy;insight;Investigation;large cell Diffuse non-Hodgkin's lymphoma;Ligands;Link;loss of function;loss of function mutation;Lymphoma;Lymphomagenesis;Malignant - descriptor;Malignant Neoplasms;Mature B-Lymphocyte;Mediating;member;Mentors;Metabolic;Modeling;Molecular;mortality;Mus;Mutation;Myeloid Cells;Normal Cell;novel;novel therapeutics;Nucleic Acid Regulatory Sequences;Nucleosomes;Oncogenes;Oncogenic;Pathogenesis;Pathologic;Patients;Penetrance;Persons;Phase;Physiological;Positioning Attribute;prevent;Process;programs;Proliferating;protein function;Protein translocation;Proteins;Proteomics;Reaction;recruit;Research;RNA;Role;skill acquisition;small molecule;Solid;Solid Neoplasm;Structure;Structure of germinal center of lymph node;T-Lymphocyte;Testing;Training;Transcription Alteration;Transcription Elongation;transcription factor;transcriptome sequencing;Treatment Protocols;tumor;Tumor Suppressor Proteins;tumorigenesis

PROJECT_TITLE: Tumor suppressive functions of TET proteins in B cell malignancies: role of G-quadruplex structures

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: HADLEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: PROJECT NARRATIVE This premise of this project is to develop the fundamental understanding of the structural factors that underlie the formation and deconstruction of supramolecular assemblies, due to covalent and non-covalent interaction between polymers and proteins. These molecular assemblies are programmable, in that these can be triggered to disassemble in the presence of a biologically relevant stimulus or a combination such stimuli. Such programmed assemblies have utility in a broad range of unmet biomedical applications.

PI_NAMEs: THAYUMANAVAN, SANKARAN  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Protein-Induced Self-Assembly and Disassembly of Nanostructures Based on Oligo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: CHARLESTON

ORG_DEPT: NEUROLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: Project Narrative Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective therapy for Parkinson’s disease (PD), however, some patients experience an unintended decrement in cognition which impacts quality of life and independence. This study will evaluate neuroimaging biomarkers to help identify the neural basis for increased vulnerability to cognitive decline. The proposed research is relevant to the NIH and NINDS missions to reduce disability and seek fundamental knowledge about the brain to reduce the burden of neurological disease.

PI_NAMEs: LENCH, DANIEL  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Acceleration;Acetylcholine;Affect;Anatomy;Anterior;Attention;Attentional deficit;Award;Basal Nucleus of Meynert;Behavioral;Brain;Brain region;career;Cerebral cortex;cholinergic;cingulate cortex;Clinical;Cognition;Cognitive;Cognitive deficits;cognitive performance;cognitive reserve;Corpus striatum structure;Data;Deep Brain Stimulation;Diffusion;Diffusion Magnetic Resonance Imaging;disability;Disabling;Dopamine;Dorsal;Dose;Dyskinetic syndrome;effective therapy;Evaluation;executive function;experience;Faculty;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;illness length;Image;imaging study;Impaired cognition;improved;Individual;Interruption;K-Series Research Career Programs;Knowledge;Language;Language Disorders;Lead;Lesion;Measures;Medial;Memory;Mentors;Mission;Motor;motor symptom;Movement Disorders;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;nerve supply;Nervous System Disorder;neural;neural network;Neurobehavioral Manifestations;Neurocognitive;neurocognitive test;neuroimaging marker;Neurologist;Neuropsychology;neuroregulation;Neurotransmitters;Operative Surgical Procedures;Parkinson Disease;Participant;Pathway interactions;Patient Selection;patient subsets;Patients;Phase;Positioning Attribute;Postoperative Period;Prefrontal Cortex;programs;Quality of life;recruit;Research;Scanning;Schedule;Secure;side effect;skills;Source;Specificity;STN stimulation;Structure;Structure of subthalamic nucleus;System;tenure track;Tissues;tool;Training;United States National Institutes of Health;Visuospatial

PROJECT_TITLE: A Neural Basis for Cognitive Decline Following Deep Brain Stimulation


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

PHR: NARRATIVE Oxygen is essential in the retina, and the deficiency of oxygen is a culprit in a broad spectrum of retinal diseases. However, it remains challenging to measure oxygen in vivo in the eye. This multidisciplinary proposal is to develop a disruptive imaging method to provide unprecedented volumetric oxygen mapping in living mouse retina, as well as a deep learning method, to translate our oxygen measurements into label-free retinal oximetry for future clinical applications.

PI_NAMEs: YI, JI  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: 3-Dimensional;adaptive optics;Address;Affect;Age related macular degeneration;algorithm training;American;Biochemistry;Blood capillaries;Blood flow;Blood Vessels;Cardiovascular system;Cell Respiration;Choroid;choroidal circulation;clinical application;clinical translation;Consumption;Data;Data Set;deep learning;design;Detection;Diabetic Retinopathy;Dyes;Eye;Fluorescence Angiography;Fundus;Future;Glaucoma;Goals;hemodynamics;Human;human imaging;Hypoxia;Image;Imaging Device;imaging modality;Imaging Techniques;improved;in vivo;Inhalation;Label;Lasers;learning network;lens;Light;Location;Machine Learning;machine learning framework;Maps;Measurement;Measures;Mediating;Medicine;Metabolic;Methodology;Methods;Microscopy;multidisciplinary;Multimodal Imaging;Mus;Nobel Prize;novel;novel imaging technique;Ophthalmoscopes;Ophthalmoscopy;Optical Coherence Tomography;optical imaging;Optics;Oxygen;Oxygen saturation measurement;Partial Pressure;Pathologic;Pathology;phosphorescence;Photons;Physiology;porphyrin a;programs;Public Health;quantitative imaging;Resolution;response;Retina;retina circulation;Retinal Diseases;retinal imaging;Role;Scanning;sensor;Signal Pathway;Signal Transduction;Speed;success;Time;Tissues;tool;Training;Translating;two photon microscopy;two-photon;Vascular System;Visible Radiation

PROJECT_TITLE: A novel method for volumetric oxygen mapping in living retina


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: SYRACUSE

ORG_DEPT: PHYSICS

ORG_NAME: SYRACUSE UNIVERSITY

PHR: Project Narrative Protein identification and quantification in challenging heterogeneous biofluids have pivotal significance in biomarker discovery. These proposed studies will impact healthcare by providing technological tools for ultrasensitive protein detection in biomedical diagnostics, quantitative proteomics, and molecular therapeutics.

PI_NAMEs: MOVILEANU, LIVIU  (contact)

PROGRAM_OFFICER_NAME: MULVANEY, SHAWN PATRICK

PROJECT_TERMS: Address;Affinity;Anisotropy;antibody mimetics;Architecture;Area;Binding;Binding Proteins;Biological;Biological Assay;Biological Markers;biomarker discovery;biomarker performance;Biosensor;Cells;Clinical;combinatorial;Complex;Crowding;design;Detection;detection limit;detector;Deterioration;Development;Diagnostic;Disease;disease prognostic;Elements;Engineering;Epidermal Growth Factor Receptor;Event;Fingerprint;Fluorescence Polarization;Formulation;Goals;Healthcare;high throughput technology;Human;Impairment;improved;Kinetics;Knowledge;Label;Libraries;Liquid substance;Malignant Neoplasms;Mammalian Cell;Masks;Measurement;Membrane Proteins;Methods;Microelectrodes;Modification;Molecular;Names;Nanostructures;Nature;next generation;Noise;operation;Outcome;Output;Performance;Physiologic pulse;polypeptide;Pore Proteins;preservation;Property;protein biomarkers;Protein Engineering;protein expression;Proteins;Proteome;Proteomics;Reading;Reagent;Reporter;Research;Resolution;Sampling;scaffold;Sensitivity and Specificity;sensor;sensor technology;Serum;Signal Transduction;Structure;Surface;targeted biomarker;Techniques;Technology;Therapeutic;Time;time use;tool;trait;Validation;Variant;Work

PROJECT_TITLE: Development of Modular Synthetic Sensors for Protein Biomarker Detection