NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: PROJECT NARRATIVE Effectively engaging men in HIV prevention remains one of the greatest challenges to driving the HIV epidemic towards elimination in sub-Saharan Africa. The objective of this project is to use an implementation science approach to establish the impact of HIV self-test distribution through male social networks, with innovative community-based support on pre-exposure prophylaxis (PrEP) uptake among men in Eastern Zimbabwe. Such a strategy aims to engage hard-to-reach men, decrease barriers to the uptake of male HIV testing prevention by reducing the need for engagement with clinics and seeks to expedite subsequent uptake of PrEP. We will use the findings of the study to model the potential population level impacts and cost-effectiveness of male peer to peer HIVST distribution strategies on the uptake of PrEP in HIV hyper-endemic settings.

PI_NAMEs: NYAMUKAPA, CONSTANCE ;TANSER, FRANK COURTENEY (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adoption;Affect;Africa South of the Sahara;African;AIDS prevention;Automobile Driving;Awareness;behavior test;Behavioral Research;Calibration;care systems;Caring;Characteristics;Clinic;cluster randomized design;Cluster randomized trial;cohort;Communities;cost effectiveness;Data;Development;Diagnostic Reagent Kits;effectiveness trial;eHealth;Epidemic;Evaluation;Face;Female Adolescents;Gender;General Population;Goals;Health;health care availability;High Prevalence;HIV;HIV Infections;HIV Seronegativity;Human immunodeficiency virus test;implementation evaluation;implementation fidelity;implementation science;Improve Access;improved;Incidence;Individual;Infrastructure;innovation;Intervention;Laboratories;Logic;male;mathematical model;Mathematics;Measures;meetings;men;Methods;Modeling;Network-based;novel strategies;Outcome;Paper;peer;peer networks;Penetration;Performance;Population;pre-exposure prophylaxis;Prevention;prevention service;primary outcome;Principal Investigator;Process;programs;public health research;Research;response;Risk;Risk Assessment;risk perception;Rural;scale up;secondary outcome;self testing;Seminal;Social Network;South Africa;Structure;study population;Subgroup;Telephone;Testing;testing services;transmission process;treatment services;uptake;Woman;Work;young woman;Zimbabwe

PROJECT_TITLE: Harnessing male peer networks to enhance engagement with HIV prevention:  A large-scale cluster randomized trial to increase HIV self-testing and PrEP uptake among men in Eastern Zimbabwe


ADMINISTERING_IC: DA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Natural Products;Neurosciences;Pediatric;Substance Misuse

ORG_CITY: BLOOMINGTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PI_NAMEs: LU, HUI-CHEN  (contact)

PROJECT_TERMS: Acute;addiction;Age;Anatomy;antagonist;Antibodies;Astrocytes;Attention;awake;Axon;Behavioral;Brain;Brain imaging;Brain region;Cannabinoids;Cannabis;career;Cell Physiology;cell type;Cells;Chronic;CNR1 gene;compulsion;Confocal Microscopy;Data;data analysis pipeline;Development;disease model;Distant;Dopamine;dopamine D3 receptor;Drug abuse;Drug Exposure;drug of abuse;drug withdrawal;endocannabinoid signaling;Endocannabinoids;Energy Metabolism;Equipment;experience;Exposure to;fetal marijuana exposure;fluorescence lifetime imaging;Functional Imaging;Glutamates;High Performance Computing;Human;Image;In Vitro;in vivo;Indiana;Intake;International;Knowledge;Measurement;Medial;Metabolic;Methodology;microscopic imaging;Midwestern United States;Modeling;Molecular;molecular scale;Monitor;monoamine;Morphology;Mus;nanoscale;National Institute of Drug Abuse;neural circuit;Neurons;novel strategies;Operative Surgical Procedures;Pattern;Perinatal;Pharmaceutical Preparations;Pharmacology;Phase;Physiological;Population;postnatal;Prefrontal Cortex;prevent;protein protein interaction;Protocols documentation;pup;Relapse;Research;Research Personnel;Rodent;Role;Scientist;sensor;Signal Transduction;Signaling Molecule;Signaling Protein;single molecule;Slice;small molecule;Somatosensory Cortex;Stains;Substance Use Disorder;superresolution imaging;THC exposure;Time;tool;Universities;Visualization;Weaning;white matter;Withdrawal

PROJECT_TITLE: Multi-Scale Imaging Core (MSIC)


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PURDUE UNIVERSITY

PHR: Word learning represents one of the major difficulties experienced by children with developmental language disorder (DLD). In this project, children with DLD participate in activities that emphasize the frequent recall of newly introduced words with the goal of significantly improving these children’s word learning outcomes. Findings from this project might serve as the foundation for the development of new methods of treatment.

PI_NAMEs: LEONARD, LAURENCE BAKER (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 5 year old;Age;Assessment tool;Child;Clinical;Cognitive Science;Development;Economics;experience;Foundations;Funding;Goals;Housing;improved;insight;interest;Investigation;Language;Language Development;Language Development Disorders;language impairment;Learning;learning ability;Learning Difficulty;learning outcome;learning strategy;Literature;Methods;Nature;novel therapeutic intervention;peer;Personal Satisfaction;Play;Population;Procedures;Psychology;Research Personnel;response;Retrieval;Role;Schedule;Semantics;Series;social;specific language impairment;Structure;therapy design;word learning;Work

PROJECT_TITLE: Retrieval-Based Word Learning in Developmental Language Disorder

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Social Determinants of Health;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative This postbaccalaureate training program is designed to provide two-year research opportunities and professional development activities to recently graduated people from diverse backgrounds that were at an undergraduate institute with limited research opportunities. Program participants are expected to develop novel research projects that will provide important new insights into the neurobiology underlying drug use and addiction. The research and education activities of the program will prepare the program participants for successful matriculation into neuroscience- related Ph.D. or M.D./Ph.D. programs.

PI_NAMEs: FERGUSON, SUSAN MARIE (contact);PHILLIPS, PAUL E. M.

PROGRAM_OFFICER_NAME: FRIEND, LINDSEY NICOLE

PROJECT_TERMS: addiction;Affect;Alaska;Alaska Native;American Indians;Awareness;Black race;career;cohort;Communication;Counseling;Coupled;Data;design;Development;Dimensions;Disabled Persons;Disparity;Disparity population;Doctor of Medicine;Doctor of Philosophy;Doctor's Degree;Drug Addiction;Drug usage;Economically Deprived Population;Education;Educational Activities;Educational Status;Educational workshop;effectiveness evaluation;Electronic Mail;Emotions;ethnic minority;Ethnic Origin;Evaluation;Event;experience;Exposure to;Faculty;Funding;Future;Gender;Geography;Goals;graduate school;graduate student;Grant;Growth;Hispanic;Historically Black Colleges and Universities;Idaho;improved;Individual;insight;interest;Journals;Knowledge;Laboratories;marginalized population;matriculation;meetings;member;Mental disorders;Mentors;minority communities;Montana;National Institute of Drug Abuse;Native American community;Neurobiology;Neurosciences;Neurosciences Research;next generation;Not Hispanic or Latino;novel;Oral;outreach;Pain;Participant;Pathway interactions;Persons;Population Heterogeneity;Postbaccalaureate;Postdoctoral Fellow;posters;Process;Program Effectiveness;programs;Questionnaires;Race;Readiness;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Schedule;Science;sex;skills;social media;Societies;stem;Students;success;Surveys;tool;Training;training opportunity;Training Programs;undergraduate education;undergraduate student;underserved community;Universities;Washington;Writing;Wyoming

PROJECT_TITLE: University of Washington Significant Opportunities in Addiction Research (UW-SOAR) Neuroscience Doctoral Readiness Program


NIH_SPENDING_CATS: Brain Disorders;Breastfeeding, Lactation and Breast Milk;Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Natural Products;Neurosciences;Substance Misuse

PI_NAMEs: BRADSHAW, HEATHER BRYTE (contact)

PROJECT_TERMS: Acute;addiction;Alcohols;Animal Model;Animals;Area;Behavioral;Biological Assay;Biological Markers;Brain Concussion;Cannabinoids;Cannabis;career;career preparation;cell type;Cells;Central Nervous System;Characteristics;Chronic;Cluster Analysis;Coupling;Data;data mining;Data Science;design;Development;Disease;Disease Progression;Drug abuse;Drug Addiction;Drug Exposure;drug maintenance;Drug Modelings;drug of abuse;Drug usage;Drug Use Disorder;Endocannabinoids;Evaluation;experience;Exposure to;Funding;genotypic sex;Glioma;guided inquiry;hands on research;Health;Human;human disease;Human Milk;Indiana;Infant Health;insight;Learning;Leukotrienes;Libraries;lipid mediator;lipidome;lipidomics;Lipids;Liver;Mass Spectrum Analysis;metabolomics;Microglia;Minority;Minority-Serving Institution;Modeling;multidrug abuse;Neurons;neurophysiology;novel;novel therapeutics;offspring;Opioid;Outcome;Pattern;Pharmaceutical Preparations;Physiology;Plasma;Play;Post-Traumatic Stress Disorders;pre-clinical;Prediction of Response to Therapy;programs;Prostaglandins;Regulation;Research;response;Rodent;Rodent Model;Role;Running;Sampling;Scientist;sex;Sex Differences;Signal Transduction;Signaling Molecule;small molecule;Structure;Students;System;targeted biomarker;Techniques;Technology;theories;Tissues;tool;Training;training opportunity;treatment response;Underrepresented Minority;underrepresented minority student;Universities;Work

PROJECT_TITLE: Bioactive Lipid Mediators Core (BLMC)


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Clinical Research;Data Science;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Sleep Research

ORG_CITY: ATHENS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: This project aligns closely with the strategic goals of HLBS by targeting a significant sleep disorder, Obstructive Sleep Apnea (OSA), which has been linked to cardiovascular, cerebrovascular, and neurological diseases. The proposed approach fosters interdisciplinary workforce development and advances translational research by bridging the gap between technology and clinical practice, facilitating a more effective management of sleep disorders and improving public and individual health outcomes.

PI_NAMEs: KE, YUAN ;PHILLIPS, BRADLEY GEORGE;SONG, WENZHAN  (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Address;Adult;Age;Apnea;Artificial Intelligence;Behavioral;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder risk;Cerebrovascular Disorders;Cessation of life;Classification;Clinical;Clinical Management;clinical practice;Computers;Data;data modeling;Data Science;data streams;deep learning;Discipline;Disease;Drowsiness;Engineering;Ensure;Event;evidence base;Failure;flexibility;Fostering;Gender;Goals;Health;Health Benefit;health practice;Heart Rate;Home;Home environment;Hypercapnia;Hypoxemia;improvement on sleep;Individual;Informatics;innovation;insight;Interdisciplinary Study;Internet of Things;Learning;Left;Link;Machine Learning;Mediating;Medical;Metabolic Diseases;Methods;Modeling;Monitor;Movement;Nervous System Disorder;neural;Noise;non-invasive monitor;novel;novel strategies;Obstructive Sleep Apnea;Outcome;Output;patient home care;Patients;Pattern;Persons;Polysomnography;Population;Process;prototype;Quality Control;Race;Real-Time Systems;recurrent neural network;Reflex action;Reproducibility;Research;Research Personnel;Respiration;response;Science;Self Management;sensor;Severities;Signal Transduction;Sleep;Sleep Apnea Syndromes;Sleep Disorders;sleep quality;Sleep Stages;Statistical Data Interpretation;statistics;Stroke;Sum;System;technological innovation;Technology;theories;Time Series Analysis;tool;Traffic accidents;Translational Research;usability;Validation;Variant;vibration;Workforce Development;Workplace

PROJECT_TITLE: SCH: Contactless and Engagement-free Sleep Apnea Monitoring and Characterization


ADMINISTERING_IC: GM

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: HOUSTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative (Relevance):  The proposed research is designed to elucidate the function and molecular mechanisms of Lsm12 as an NAADP receptor in NAADP-evoked calcium signaling. The findings of the proposed research will help in identifying new drug targets and therapeutics for NAADP signaling-related diseases.

PI_NAMEs: YAN, JIUSHENG  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Affect;Affinity;Affinity Chromatography;Agonist;analog;Binding;Binding Sites;Biochemical;Biological;Calcium;Calcium Signaling;Cell Line;Cell Physiology;Cells;Complex;Data;Defect;design;Development;Disease;Electrophysiology (science);Endosomes;Factor V;genetic regulatory protein;Human;Immobilization;innovation;Ion Channel;Knockout Mice;Knowledge;Label;Lipids;Lysosomes;Mammalian Cell;Mediating;Membrane;Molecular;Mutation;NAADP;NADP;new therapeutic target;Nicotine Dependence;novel;novel therapeutics;Organelles;Physiological Processes;Play;Process;Property;Protein Dephosphorylation;protein function;protein protein interaction;Proteins;Proteomics;receptor;Regulation;Reporting;Research;response;RNA-Binding Proteins;Role;Second Messenger Systems;Signal Transduction;Source;Testing;Therapeutic

PROJECT_TITLE: Molecular basis of the NAADP-gated calcium release channel complexes

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: Los Angeles

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Narrative:  Tissue patterning is a fundamental process that establishes complex skin architectures required for optimal skin functions. We have used the developing skin as experimental models to study the morphogenetic processes involved in the generation of multiple appendage units, the formation of cyclic renewable follicles, and the assembly of the muscle network. The newly learned principles and concepts will enhance our ability to promote tissue patterning in engineered skin and to move forward toward applications in future regenerative medicine.

PI_NAMEs: CHUONG, CHENG-MING  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: 3-Dimensional;Adult;appendage;Architecture;Back;Biochemical;Biological Assay;Biomechanics;Biophysical Process;Biophysics;Blood Vessels;Calcium Channel;Cell Communication;cell motility;Cell Polarity;Cells;Chemicals;Chick Embryo;Competence;Complex;Coupling;Cutaneous Muscle;Dermal;Dermis;Development;Diffusion;Embryo;Engineered skin;Epigenetic Process;Epithelium;Event;Experimental Models;Extracellular Matrix;Feathers;Fibroblast Growth Factor;Fluorescence Resonance Energy Transfer;Funding;Future;Gap Junctions;Generations;Genes;Hair;Hair follicle structure;Image;in vivo;inhibitor;Knowledge;Lead;Learning;Link;Maps;Matrix Metalloproteinases;mechanical force;Mechanics;member;MMP14 gene;Molecular;Morphogenesis;morphogens;Morphology;movie;Mus;Muscle;Natural regeneration;Nerve;Newborn Infant;next generation sequencing;novel;Organ;Organoids;Pathogenesis;Pathway interactions;Pattern;Pattern Formation;Periodicals;Periodicity;Peripheral;physical property;Physiological;planar cell polarity;Play;Primordium;Process;Progress Reports;Property;Publications;reconstitution;Regenerative Medicine;Regenerative wound healing;Role;Second Messenger Systems;self organization;Signal Transduction;Skin;skin morphogenesis;skin regeneration;Smooth Muscle Myocytes;Specific qualifier value;stem cells;Stretching;Structure;Tenascin;Tissue Engineering;tissue mapping;Tissues;tongue papilla;transcriptome sequencing;Work

PROJECT_TITLE: Tissue Patterning in living skin and organ ex


NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Natural Products;Substance Misuse

PI_NAMEs: HAJOS, NORBERT  (contact)

PROJECT_TERMS: addiction;Address;Adolescent;African-American Graduate Student;Anatomy;Applications Grants;Area;Cannabinoids;Cannabis;career;Career Choice;Clinical;cognitive change;Data;design;Drug abuse;Drug Addiction;Drug usage;Education;Educational Status;Ensure;Equity;Experimental Designs;experimental study;Feedback;Funding;Gills;Goals;graduate student;Grant;high risk;Human;Image;Indiana;Individual;Inhalation;innovation;insight;interest;Kentucky;Knowledge;lipidome;lipidomics;Lipids;Location;meetings;member;Mentors;Methodology;mild traumatic brain injury;Modeling;Molecular;multiple drug use;National Institute of Drug Abuse;Nature;Neurosciences;novel;Opioid;opioid user;Outcome;phytocannabinoid;Pilot Projects;Plasma;Population;Postdoctoral Fellow;Process;process improvement;professor;programs;Publications;Rattus;recruit;Research;Research Personnel;Resources;Scientist;skills;Societies;Substance abuse problem;success;Summary Reports;Support Groups;System;Talents;Techniques;THC exposure;Traumatic Brain Injury;Universities;Work;Writing

PROJECT_TITLE: IUB C3A Pilot Project Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The function of many rogue, disease-causing proteins cannot not be easily blocked using a small molecule drug approach, hence they are ‘undruggable’. To address this, we propose to simply eliminate or inactivate these unwanted proteins from the body instead of trying to use drugs to block their function. Here we describe the development of a new classes of drugs that target ‘undruggable’ proteins for destruction or inactivation and propose to implement these new pharmaceutical strategies against problem proteins that play key roles in oncology.

PI_NAMEs: CREWS, CRAIG M (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Academia;Address;bench to bedside;Cell Culture Techniques;Clinical;Clinical Trials;Development;Disease;drug candidate;drug development;Drug Industry;Drug Targeting;Drug usage;FDA approved;first-in-human;Future;Genomics;in vivo;innovation;knock-down;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Modality;Multiple Myeloma;novel;novel anticancer drug;novel drug class;novel therapeutics;Nuclear Hormone Receptors;Oncogenic;Oncology;Oncoproteins;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Play;Proteasome Inhibitor;protein degradation;Proteins;Proteolysis;proteostasis;recruit;Refractory;Relapse;Research;Small Interfering RNA;small molecule;success;Technology;Translating;translational cancer research;tumor;ubiquitin-protein ligase;Validation;wasting;Work

PROJECT_TITLE: Inducing Proximity: An Emerging Paradigm for New Therapeutic Modalities


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Aedes aegpyti is a major vector of dengue, Zika, and chikungunya. We propose to explore the differences between the sex chromosomes to develop mosquito control methods by tipping the balance towards the non-biting males.

PI_NAMEs: TU, ZHIJIAN JAKE (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: active control;Address;Aedes;Anopheles gambiae;Area;autosome;Biological;Cells;chikungunya;Chikungunya virus;Chromatin;Chromosome 1;Chromosome Breakage;Chromosome Pairing;Chromosomes;cost;CRISPR/Cas technology;Culex (Genus);Culicidae;Dengue;Dengue Vaccine;Dengue Virus;Dengvaxia;Disease Outbreaks;disease transmission;disorder control;Economics;Equilibrium;Female;fitness;Future;Gene Targeting;Genes;genetic approach;genetic manipulation;Genetic Transcription;Geography;Germ Lines;Haplotypes;improved;Incidence;innovation;innovative technologies;Insecticide Resistance;insight;Laboratories;Link;male;Male Sterility;Measures;Meiosis;Methods;Minor Lymphocyte Stimulatory Loci;Mitosis;Modeling;Molecular;Mosquito Control;Mosquito-borne infectious disease;Myeloma Proteins;Names;novel;Population;Population Growth;Population Replacements;Prevention;Probability;programs;promoter;Property;prototype;Recommendation;Research;Resistance;RNA-Binding Proteins;sex;Sex Bias;Sex Chromosomes;Sex Differences;Sex Ratio;Site;Specificity;sperm cell;Split Genes;Surveys;System;Testing;Time;tool;transgene expression;Transgenes;Transgenic Organisms;transmission process;vector;vector control;vector management strategies;Wolbachia;Wood material;X Chromosome;Y Chromosome;ZIKA;Zika Virus

PROJECT_TITLE: Sex ratio distortion in Aedes aegypti

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)M]


NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Chronic Pain;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Osteoarthritis;Pain Research;Physical Activity;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project narrative Osteoarthritis is a common and serious disease, and there are likely multiple different subtypes, or phenotypes. This proposal will enhance the candidate’s abilities and capacities in patient-oriented research (POR) and mentoring through aims focused on the intersection of POR, health equity (opportunities for all to have good health), and machine learning (computer algorithms) to examine different osteoarthritis phenotypes in two diverse population-based cohorts, leveraging extensive existing data. The proposed midcareer investigator award project represents a necessary step towards understanding risk factors and outcomes in osteoarthritis and is relevant to the NIAMS mission of achieving health equity and understanding differences in disease across diverse groups of people.

PI_NAMEs: NELSON, AMANDA E (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Accelerometer;Address;Age;Age Years;aged;algorithm development;Algorithms;Area;Artificial Intelligence;artificial intelligence algorithm;Award;Big Data Methods;Biological Markers;Black race;career;Chronic Disease;clinical center;Clinical Data;Clinical Investigator;Clinical Research;cohort;Cohort Studies;Computational algorithm;County;Creatinine;Data;Data Sources;deep learning algorithm;Degenerative polyarthritis;Development;Disease;diversity and equity;effective therapy;Enrollment;Epidemiology;epidemiology study;Ethnic Origin;Event;experience;Funding;Future;Gait speed;Glean;Goals;Health;health equity;health inequalities;Healthcare Systems;Hispanic;Image;improved;indexing;Individual;individual variation;Inequity;Infrastructure;insight;Institution;interest;Intervention;Joints;Knee;Knee Osteoarthritis;knee pain;Longitudinal Studies;Machine Learning;Measures;Medical;men;Mentors;Methodology;Methods;Midcareer Investigator Award in Patient-Oriented Research;Mission;Modeling;Musculoskeletal Diseases;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;osteoarthritis pain;Outcome;Pain;pain catastrophizing;patient oriented research;Patient Self-Report;Patients;Performance;Persons;Phenotype;Physical activity;population based;Population Heterogeneity;precision medicine;programs;Publishing;Pulmonary function tests;Questionnaires;Race;racial difference;radiological imaging;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Rheumatism;Risk;Risk Factors;Role;Sampling;Scientist;Self Assessment;sex;Sex Differences;skills;Socioeconomic Status;socioeconomics;Structure;Subgroup;Symptoms;Testing;Therapeutic;Time;Training;Validation;Woman;Work

PROJECT_TITLE: Mentoring in Patient Oriented Research in Osteoarthritis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE The primary focus of this project is to investigate the neural mechanisms of age-related attentional distractibility, focusing on the neural circuit between the locus coeruleus and the salience network (LC-SN), by utilizing both human brain imaging and an animal-model based circuit-selective gene manipulation approach. We will examine the effects of aging on the LC-SN network using a mouse model, test whether LC-SN dysconnectivity increases attentional distractibility in human older adults, and rescue the attentional deficit in both aged mice and human older adults (including, as an exploratory variable, family history of Alzheimer’s disease within our human studies). The successful implementation of this research may have significant translational implications to identify and protect against attentional declines in the context of typical aging, as well as among those at-risk for ADRD.

PI_NAMEs: KATZ, BENJAMIN D;KIM, IL HWAN ;LEE, TAE-HO  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: age effect;age related;age related decline;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Animal Model;Animals;Area;Attention;Attentional deficit;Behavior;Behavioral;Brain;Brain imaging;Cognitive;Cognitive aging;cognitive training;Compensation;Data;dementia risk;Exhibits;Failure;Family;Family history of;First Degree Relative;Functional disorder;Future;Genetic;genetic manipulation;Human;Human Characteristics;human imaging;human model;Image;imaging approach;Imaging Techniques;Impairment;improved;In Vitro;in vivo;Individual;interest;Knowledge;Laboratories;Link;Location;locus ceruleus structure;Magnetic Resonance Imaging;Measures;Modeling;Molecular;Morphology;mouse model;multimodality;Mus;network models;neural;neural circuit;neural network;neural tract;Neurobiology;neuromechanism;neuromelanin;Neuronal Plasticity;Noise;novel;old mice;older adult;Parents;Pathologic;Pathway Analysis;Performance;Physiological;programs;Published Comment;Recording of previous events;Research;Research Design;response;Rest;Role;selective attention;Siblings;Signal Transduction;Specificity;Symptoms;Testing;therapeutic target;Training;Training Programs;Transgenes;Visualization;Work;young adult

PROJECT_TITLE: Losing specificity: the role of the locus coeruleus in age-related distractibility

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative  This proposed research is expected to not only identify novel and (putative) causal genes, proteins and brain re- gions for Alzheimer's disease through integrative post-GWAS data analysis, but also contribute powerful and robust statistical and machine learning methods for causal inference as valuable computational tools for the elucidation of genetic components of common diseases, thus facilitating their prevention, early diagnosis and therapeutic development.

PI_NAMEs: PAN, WEI  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Algorithms;Alzheimer's Disease;Alzheimer's disease risk;Biological;Brain region;causal variant;cognitive system;Communities;Complex;Computer software;computerized tools;Data;Data Analyses;Data Set;deep learning;deep neural network;Disease;DNA Methylation;Documentation;drug development;Early Diagnosis;endophenotype;Epigenetic Process;epigenomics;Etiology;flexibility;functional genomics;Gene Expression;Genes;Genetic;genetic association;Genetic Diseases;genetic predictors;Genome;genome sequencing;genome wide association study;genome-wide;genomic data;Genomics;Goals;Image;improved;Influentials;insight;interest;Intervention;Knowledge;Least-Squares Analysis;Linear Models;Linear Regressions;machine learning method;Methods;Modeling;modifiable risk;Molecular;Molecular Target;Motivation;neural network;Neural Network Simulation;neuroimaging;Non-linear Models;novel;Operant Conditioning;Outcome;phenotypic data;pleiotropism;predictive modeling;Prevention;programs;protective factors;Protein Region;Proteomics;Public Domains;Publishing;Pythons;Relaxation;Research;response;Risk;Risk Factors;Sampling;software development;statistical and machine learning;Systems Analysis;Technology;TensorFlow;Therapeutic;therapeutic development;therapy development;Time;trait;transcriptome;transcriptomics;whole genome;Writing

PROJECT_TITLE: Causal and integrative deep learning for Alzheimer's disease genetics


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Viral infections like SARS-CoV-2 can induce devastating damage on the lungs resulting in the acute respiratory distress syndrome (ARDS). Neutrophils are an immediate responder to viral pneumonia and release neutrophil extracellular traps (NETs) in an attempt to help control infections. In this proposal, we will generate new understanding on how NETs contribute to COVID-19-induced ARDS, and test new strategies to prevent and/or treat this disease.

PI_NAMEs: LOONEY, MARK ROBERTS (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;ACE2;Acute Lung Injury;Acute Respiratory Distress Syndrome;Alveolar;aspirate;Attention;Biological;Biology;Blood;Cause of Death;Cessation of life;Chromatin;Coagulation Process;cohort;Complement;Complement Activation;Containment;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19/ARDS;Deoxyribonucleases;Development;Disease;effective therapy;Excess Mortality;experimental study;Explosion;extracellular;Extracellular Space;Feedback;gain of function;grasp;Host Defense;Human;in vivo;Infection;Infection Control;Influenza;Influenza A virus;Knowledge;Literature;loss of function;loss of function mutation;Lung;Lung infections;lung injury;Mass Spectrum Analysis;Measures;microbial;Modeling;Molecular;mortality;mouse model;Mouse Strains;Mus;neutrophil;Neutrophil Activation;Neutrophilia;new pandemic;novel;novel strategies;novel therapeutic intervention;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peptide Hydrolases;peripheral blood;Persons;Plasma;Platelet Activation;Pneumonia;Positioning Attribute;post SARS-CoV-2 infection;Predisposition;prevent;Process;Production;Proteins;Proteomics;Reporting;respiratory pathogen;response;Role;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Sepsis;Serum;severe COVID-19;Severities;Sterility;Testing;Therapeutic;therapeutic evaluation;therapeutic target;tissue injury;Trachea;Transgenic Organisms;viral pandemic;Viral Pathogenesis;Viral Pneumonia;Virus;Virus Diseases

PROJECT_TITLE: Mechanisms and pathogenicity of SARS-CoV-2-induced neutrophil extracellular traps

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Clinical Research;Diabetes;Digestive Diseases;Genetics

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: PROJECT NARRATIVE While diabetes is a known complication of acute pancreatitis (AP), a full understanding of the underlying etiology of this disorder is lacking. To address this gap in knowledge, we have assembled a multidisciplinary team at Indiana University, with expertise in exocrine pancreas pathophysiology, diabetes, β cell biology, genetics, and pancreatic imaging. As part of the newly formed Type 1 Diabetes in Acute Pancreatitis Consortium, members of the Indiana University Clinical Center will collaborate with other consortium members to undertake studies focused on the comprehensive clinical, epidemiological, biological and imaging characterization of diabetes occurring after AP.

PI_NAMEs: EVANS-MOLINA, CARMELLA ;FOGEL, EVAN L (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: 3-Dimensional;acute pancreatitis;Address;Adult;Affect;Alpha Cell;Ancillary Study;Arginine;Artificial Intelligence;Autoantibodies;Beta Cell;biobank;Biological;Biological Markers;biomarker development;Cell Death;Cell Physiology;Cellular biology;Cellular Stress;Clinical;clinical center;clinical phenotype;Clinical Research;clinical risk;Closure by clamp;Collaborations;Complication;contrast enhanced;Data;Defect;Development;Diabetes Mellitus;diabetes mellitus genetics;diabetic patient;Diffusion Magnetic Resonance Imaging;Disease;Duodenum;Endocrine;endocrine pancreas development;Enrollment;Epidemiology;Etiology;euglycemia;Evolution;Exhibits;Exocrine pancreas;Exocrine pancreatic insufficiency;extracellular;Extracellular Matrix;Fatty acid glycerol esters;Functional disorder;Genetic;genetic analysis;Genomic DNA;Glucagon;Glucose;Glucose Intolerance;glucose tolerance;Goals;Health;Hyperglycemia;Image;Imaging Techniques;Immune;immune activation;Immunologics;Impaired fasting glycaemia;impaired glucose tolerance;Impairment;Incidence;Indiana;Individual;Infiltration;Insulin;Insulin deficiency;Insulin Resistance;insulin secretion;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Investigation;islet autoimmunity;Islet Cell;islet cell antibody;Knowledge;Liquid substance;Longitudinal Studies;Magnetic Resonance;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Measurement;Measures;medical schools;member;Meta-Analysis;Metabolic;Metabolic dysfunction;metabolic phenotype;Methodology;Monitor;Morphology;Motion;multidisciplinary;Natural History;Nested Case-Control Study;non-diabetic;novel;Observational Study;OGTT;Pancreas;pancreas imaging;Pancreatic Function Tests;Pancreatitis;participant enrollment;Patients;Perfusion;Phenotype;Physiological;Plasma;polygenic risk score;Population;prospective;Qualifying;radiomics;Relaxation;Reporting;repository;Research Personnel;response;Risk;Risk Factors;Risk Marker;Secretin;Serum;Signal Transduction;Structure of beta Cell of islet;Subgroup;Techniques;Testing;Texture;Time;Tissues;type I and type II diabetes;Universities;Urine;Work

PROJECT_TITLE: Indiana University clinical Center for acute pancreatitis and diabetes clinical research network


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Social Determinants of Health;Vaccine Related

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: Project Narrative The trajectory of the COVID-19 epidemic is shaped by individual behavior. We propose the development of new transmission models of COVID-19 and seasonal inﬂuenza that study the interplay between individual behavior and transmission dynamics, while considering important uncertainties, such as seasonal effects and the loss of immunity. Building on our prior work on vaccination behaviors for inﬂuenza and the transmission of COVID-19, these models will be informed by tailored longitudinal surveys, observed behavior, and case data from the ongoing pandemic, and we will develop tools that run our models and allow users to identify the effects of behavioral factors on policy effectiveness, evaluate the potential impact of vaccine availability, and identify strategies that are robust to a wide range of uncertainties.

PI_NAMEs: PARKER, ANDREW ;VARDAVAS, RAFFAELE  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Accounting;Adaptive Behaviors;Affect;Age;Attitude;Back;Behavior;behavior change;Behavioral;Behavioral Model;behavioral response;Belief;Calibration;Cessation of life;Characteristics;Circulation;Cities;Clinical Medicine;Communicable Diseases;comparison intervention;Complex;Coupled;COVID-19;COVID-19 pandemic;COVID-19 vaccine;Data;Data Set;Decision Making;decision research;Development;Disease;disease transmission;economic outcome;Effectiveness;Ensure;Epidemic;Epidemiology;experience;falls;Fatigue;Funding;Funding Agency;Future;Health;Healthcare Systems;Heterogeneity;Immunity;Individual;Infection;Influenza;insight;interactive tool;Intervention;Longitudinal Studies;Longitudinal Surveys;machine learning method;Masks;mathematical model;Measures;medical supply;Memory;Methods;Modeling;models and simulation;National Institute of Allergy and Infectious Disease;novel vaccines;Online Systems;Outcome;outcome forecast;pandemic disease;Pattern;peer;Perception;Periodicals;Persons;Policies;population based;Population Heterogeneity;prevent;protective behavior;Psychology;Reaction;Research;Resources;Respiratory Signs and Symptoms;Respiratory Tract Infections;Respondent;response;Risk;Risk Behaviors;risk perception;Running;Sampling;SARS-CoV-2 transmission;seasonal influenza;Seasons;Shapes;Signal Transduction;social;social contact;Social Distance;social media;Social Network;socioeconomics;Speed;Structure;Surveys;Technology;Testing;tool;Translating;transmission process;Uncertainty;US State;user-friendly;Vaccinated;Vaccination;vaccine access;vaccine effectiveness;Vaccines;Variant;Virulent;Virus;Virus Diseases;Work

PROJECT_TITLE: Modeling the Coupled Dynamics of COVID-19 Transmission and Protective Behaviors

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Women's Health Research

PHR: PROJECT NARRATIVE The I-SPY 2 neoadjuvant breast cancer clinical trial is a personalized, adaptive trial designed to improve outcomes in high-risk breast cancer patients. This study seeks to unravel the complex interactions between intrinsic host germline and tumor somatic mutations, and extrinsic tumor microenvironment features that drive the biology of response or resistance to therapy. This research aims to generate genomic and tumor microenvironment response-predictive biomarkers that improve on current qualifying biomarkers – providing better stratification of patients and directing them to best predicted interventions – and that identify possible alternative treatment strategies for non-responders – reducing unnecessary therapeutic burden.

PI_NAMEs: SAYAMAN, ROSALYN WONG (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Address;Affect;Age;alternative treatment;Autoimmune;Beds;Biological;Biological Markers;Biology;Body mass index;BRCA1 gene;Breast;Breast Cancer Patient;Breast Oncology;California;Cancer Burden;Cancer Center;cancer clinical trial;cancer genomics;career development;Caring;cell type;Cells;chemokine;Clinical;Clinical Data;Clinical Trials;Complex;Comprehensive Cancer Center;Computational Biology;Copy Number Polymorphism;Country;cytokine;Data;Data Set;density;Department chair;Development;DNA Repair;DNA Repair Disorder;Doctor of Philosophy;Environment;Ethnic Origin;exome sequencing;experience;explainable machine learning;Extracellular Matrix;Faculty;Family;Fluorescence;fluorescence imaging;Gene Expression;gene interaction;Genes;Genetic;Genomics;Germ Lines;Germ-Line Mutation;Goals;Guidelines;Heritability;high risk;Hypoxia;IFIH1;Immune;immune cell infiltrate;Immune response;Immunofluorescence Immunologic;immunological status;Immunology procedure;immunoregulation;Immunotherapy;improved;improved outcome;In complete remission;in silico;Institution;Interferons;International;Intervention;Laboratories;Learning;Machine Learning;machine learning algorithm;machine learning classification;machine learning method;machine learning model;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Medicine;Mentors;Metabolic;Methodology;Methods;Modeling;multidisciplinary;Multiomic Data;multiple omics;Mutation;Neoadjuvant Therapy;neoantigens;novel;oncology program;optimal treatments;Outcome;Pathologic;Pathway interactions;patient response;patient stratification;Patients;personalized medicine;Population;Positioning Attribute;predict clinical outcome;predicting response;predictive marker;predictive modeling;Predictive Value;Predisposition;Principal Investigator;Prognosis;programs;Publications;Publishing;Qualifying;Race;receptor;Reporting;Research;research and development;Research Proposals;Residual Cancers;response;risk variant;Role;Sampling;San Francisco;Signal Pathway;Signal Transduction;Single Nucleotide Polymorphism Map;SNP genotyping;Solid;Somatic Mutation;STING1 gene;Stromal Cells;Systems Biology;T-Lymphocyte Subsets;targeted treatment;Technology;tenure track;Testing;The Cancer Genome Atlas;Therapeutic;therapy resistant;Time;Training;trait;transcriptomics;translational medicine;treatment arm;treatment response;treatment strategy;trial design;tumor;tumor immunology;tumor microenvironment;Tumor-infiltrating immune cells;Universities;unsupervised clustering;Woman;Work

PROJECT_TITLE: A systems biology approach to elucidate the biology of immune-associated outcomes in breast cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Rural Health

ORG_CITY: LITTLE ROCK

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE  The Data Coordinating and Operations Center (DCOC) for the IDeA States Pediatric Clinical Trials Network will facilitate the development, implementation and reporting on multicenter clinical trials that address the health needs of children living in IDeA states. Since populations in IDeA states are disproportionately rural and medically underserved, the clinical trials findings should have implications for those populations. The DCOC will also collaborate with the clinical investigators in enhancing the clinical trial workforce to improve the environment for conducting clinical trials in the IDeA states.

PI_NAMEs: COURTNEY, SHERRY ;OUNPRASEUTH, SONGTHIP T. (contact);PRIOR, FRED WILLIAM

PROGRAM_OFFICER_NAME: RAJU, TONSE N

PROJECT_TERMS: Address;Affect;age difference;Airway Disease;Area;Arkansas;Award;Biomedical Research;Biometry;Biostatistics Core;Caring;Centers of Research Excellence;Child;Child Care;Child Health;Childhood;Clinical;Clinical and Translational Science Awards;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Cooperative Group;Clinical Trials Network;Collaborations;college;community engagement;Conduct Clinical Trials;Data;Data Coordinating Center;data management;design;Development;Diagnosis;Disease;Dissemination and Implementation;Doctor of Philosophy;drug metabolism;Eligibility Determination;Environment;evidence base;experience;Functional disorder;Funding;Future;Grant;Health;improved;Informatics;Infrastructure;Institution;interest;Leadership;Medical;medically underserved;medically underserved population;Medicine;member;Mentors;Methodology;Multi-Institutional Clinical Trial;Multicenter Studies;Nebraska;neurodevelopment;Obesity;operation;Outcome;Patients;pediatric department;pediatric patients;Pediatric Research;Perinatal;Physicians;Pilot Projects;Population;Population Distributions;Population Heterogeneity;postnatal;prenatal;Prevention;Principal Investigator;programs;Publishing;Randomized, Controlled Trials;Recording of previous events;Reporting;Research;Research Activity;research and development;Research Institute;Research Personnel;Research Project Grants;Rural;rural area;rural underserved;Science;Scientist;Site;skill acquisition;Training and Education;Translational Research;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Data Coordinating and Operations Center for the ECHO IDeA States Pediatric Clinical Trials Network


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health

ORG_NAME: RICE UNIVERSITY

PHR: Project Narrative This study is novel in applying the theoretical perspective of work-family conflict to ADRD caregivers with psychoneuroimmunological methods. If our hypotheses are supported, researchers will better understand the role of employment as a risk factor to caregivers’ psychosocial functioning and chronic inflammaiton. By identifying if employment and psychosocial variables are predictors of higher chronic inflamation, we will be better able to identify caregivers most at risk and tailor effective interventions.

PI_NAMEs: PAOLETTI, JENSINE  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Atherosclerosis;Bereavement;Cardiovascular Diseases;cardiovascular risk factor;care giving burden;Caregiver Burden;Caregivers;caregiving;Caring;Chronic;Chronic stress;Conflict (Psychology);cytokine;Data;Dementia;Dementia caregivers;dementia caregiving;effective intervention;emotion regulation;Emotions;Employee;Employment;Employment Status;Equilibrium;Exhibits;experience;Family;Family Caregiver;family caregiving;Fatigue;Feeling;Foundations;frailty;Funding;Future;Health;Health Psychology;Hour;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Intervention;Investigation;Leisures;Life;Linear Regressions;Longitudinal Studies;Malignant Neoplasms;Mediating;Mediation;Mediator;Mental Depression;Mental Health;Methods;Modeling;mortality;National Research Service Awards;Non-Insulin-Dependent Diabetes Mellitus;novel;Occupational Health;Occupations;Osteoporosis;Outcome;Patient Self-Report;Patients;perceived stress;physical conditioning;poor health outcome;Poverty;Premature aging syndrome;Production;prognostic;Psychoneuroimmunology;psychosocial;Psychosocial Factor;Research;Research Design;Research Personnel;Rest;retiree;Risk;Risk Factors;Role;Sampling;Social Environment;Spouse Caregiver;Spouses;Stress;stressor;Testing;theories;Time;Widow;Work;Workplace

PROJECT_TITLE: Employment Status, Psychosocial Functioning, and Chronic Inflammation Among Dementia Spousal Caregivers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(21)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Burden of Illness;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: This trial is important as it will help to better understand the extent that child gastrointestinal illnesses (GI) can be attributable to consuming untreated private well water and which viral, bacterial and protozoan pathogens are the most likely contributors of GI in these water supplies. The results will help inform GI burden estimates and policy decisions regarding the management of private well water supplies globally and across the United States.

PI_NAMEs: MURPHY, HEATHER M (contact)

PROGRAM_OFFICER_NAME: FLORESE, RUTH HUAB

PROJECT_TERMS: Accounting;Adenoviruses;Advisory Committees;Age;Bacteria;burden of illness;Campylobacter;Canada;Child;Childhood;Communities;Consumption;cost;Cryptosporidium;Data;Devices;Diarrheagenic E. coli;Disease;disease transmission;drinking water;Elderly;Enteral;enteric infection;enteric pathogen;Enterovirus;epidemiologic data;Epidemiologic Methods;Feces;gastrointestinal;Giardia;ground water;Health;Health Care Costs;high risk;Household;Immune;Immunocompromised Host;Incidence;Intervention;Knowledge;Link;microbial;Modeling;Norovirus;Paper;pathogen;Pennsylvania;Persons;Placebos;Policies;Privatization;Protozoa;Publishing;randomized trial;Randomized, Controlled Trials;Recreation;Risk;Risk Assessment;Risk Estimate;rural families;Salmonella;Schools;Shigella;Source;stool sample;System;Testing;Ultraviolet Rays;United States;Viral;Virus;Vulnerable Populations;Washington;Water;Water consumption;water quality;water sampling;Water Supply;water treatment;waterborne illness;waterborne pathogen;well water;Wisconsin;Work

PROJECT_TITLE: Wells and Enteric Disease Transmission: A randomized trial of children supplied drinking water from private wells (WET-Trial)

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE Effective targeted therapies remain to be found for pancreatic cancer, the 3rd leading cause of cancer deaths in the US, and surpassing colorectal cancer in 2020 to become the 2nd leading cause of cancer deaths. With KRAS mutations found in ~95% of pancreatic cancers, it is well-accepted that effective anti-KRAS therapies will provide successful treatments for this deadly cancer. Based on recent unpublished observations, we propose four provocative directions not widely pursued by the RAS and cancer research field to make “undruggable” KRAS druggable.

PI_NAMEs: DER, CHANNING J. (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Adherence;anti-cancer research;Automobile Driving;Autophagocytosis;Award;Biochemistry;Biology;Cancer Etiology;cancer therapy;Cessation of life;clinical efficacy;Colorectal Cancer;Defect;Dependence;Development;Enzymes;Frequencies;Glycolysis;Goals;Growth;high reward;high risk;Human;Impairment;KRAS2 gene;Mainstreaming;Malignant neoplasm of pancreas;Malignant Neoplasms;member;Metabolic;Mitochondria;mutant;Mutation;MYC Family Protein;MYC gene;neglect;novel;Pancreatic Ductal Adenocarcinoma;PIK3CG gene;Play;Protein Kinase;ras Oncogene;ras Proteins;Research;Research Personnel;Research Support;Resistance;Risk;Role;Signal Transduction;targeted treatment;therapeutically effective;tumor metabolism

PROJECT_TITLE: Targeting undruggable RAS for cancer treatment


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: US HELPING US, PEOPLE INTO LIVING, INC.

ORG_STATE: DC

PHR: PROJECT NARRATIVE Stark inequities in pre-exposure prophylaxis (PrEP) use, retention in PrEP care, PrEP adherence, and PrEP protection persist among Black sexual minority men (SMM) and HIV incidence continues to increase among certain segment of Black SMM, especially those in the Southeastern United States (U.S.). This signifies a critical failure of the U.S. public health system and the need to: (1) investigate the concomitant and intersecting associations of anticipated, perceptions, and experiences of RD at multiple levels with key PrEP continuum outcomes; (2) assess the moderating effects of resiliency factors on the link between multilevel RD and PrEP continuum outcomes, and (3) triangulate quantitative, qualitative and social mapping data to validate causal relationships and identify possible social-structural and/or strengths-based interventions that may mitigate the effects of multilevel RD on PrEP continuum outcomes. The combination of novel multilevel RD and resiliency measures and robust phenotypic PrEP biomarker data, in addition to the study population and location, represents a significant advancement in HIV prevention and has the potential to increase the number of Black SMM who initiate and adhere to PrEP and ultimately reduce HIV incidence, which aligns with the federal plan to End the HIV Epidemic by 2030, the National HIV/AIDS Strategy and funding priorities of the NIH.

PI_NAMEs: HICKSON, DEMARC A (contact)

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: Adherence;AIDS prevention;Awareness;Biological;Biological Markers;black men;black men who have sex with men;Black race;Blood;Buffers;cardiovascular health;Caring;Cities;Cohort Studies;Collection;Communities;community academic partnership;Conscious;Data;Deep South;Development;Diagnosis;Discrimination;Economic Factors;Environmental Risk Factor;Epidemic;Epidemiology;experience;Failure;Focus Groups;follow-up;Funding;Future;Geography;Health;health care settings;health inequalities;Health system;Healthcare;HIV;HIV diagnosis;HIV disparities;HIV Seronegativity;HIV/AIDS;Homophobia;Homosexuality;Human immunodeficiency virus test;Hydrocortisone;Incidence;Individual;Inequity;innovation;insight;interest;Intervention;Knowledge;Life;Link;Location;male health;Maps;Measurement;Measures;Medical;men who have sex with men;men's group;Methodology;Methods;Minority;minority stress;minority stressor;Modeling;multidisciplinary;multilevel analysis;National Institute of Mental Health;National Institute on Minority Health and Health Disparities;Neighborhoods;novel;Outcome;Participant;Pathway interactions;Patient Self-Report;perceived discrimination;Perception;Pharmaceutical Preparations;Phase;Phenotype;Political Factor;Population;pre-exposure prophylaxis;prevention service;Prevention strategy;prospective;Public Health;Race;racism;recruit;Religiosity;Research;resilience;resilience factor;Risk Behaviors;Role;Sampling;self esteem;Sexual Health;sexual minority community;sexual minority men;sexual minority status;Sexually Transmitted Diseases;Site;social;Social Adjustment;social factors;social stigma;social structure;Social support;Southeastern United States;Spirituality;Stress;Stressful Event;stressor;Structural Racism;study population;success;Surveys;Techniques;Testing;theories;Time;trait;trend;United States;United States National Institutes of Health;uptake;Washington

PROJECT_TITLE: Multilevel Racism & Discrimination and PrEP Outcomes Among Black SMM in the Southeastern U.S.


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE TO PUBLIC HEALTH Langerhans cells are resident cells of skin that participate in the immune responses. We propose to study leprosy as a model to gain insight into the mechanism by which Langerhans cells indirectly contribute to host defense against infection by the activation of T cells and directly mediate antimicrobial responses.

PI_NAMEs: MODLIN, ROBERT L (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: adrenomedullin;Amino Acids;Anti-Bacterial Agents;anti-microbial peptide;Antigen Presentation;Antigen Presentation Pathway;Antigens;antimicrobial;Autophagocytosis;Bacteria;Bacterial Proteins;C-Type Lectins;cathelicidin;CCL17 gene;CCL22 gene;CD1 Antigens;cell killing;Cell Line;Cell Physiology;Cells;Cellular biology;Clinical;combat;Cutaneous;CXCL2 gene;Data;Dendritic Cells;differential expression;Epidermis;Epitopes;Funding;Gene Expression;Genes;Goals;Host Defense;Host Defense Mechanism;human model;Hydrophobicity;Immune response;Immunobiology;Infection;innate immune function;insight;Interferon Type II;Laboratories;Langerhans cell;langerin;Lepromatous Leprosy;Leprosy;Lesion;Ligand Binding;Link;Lipids;Location;Macrophage;Maps;Mediating;microbial;Modeling;Molecular;Mycobacterium leprae;novel;pathogen;pathogenic microbe;Pathway interactions;Patients;peptide structure;Peptides;perforin 2;Progressive Disease;Proteins;Public Health;Reaction;response;Ribosomes;Role;single-cell RNA sequencing;Skin;skin disorder;skin lesion;Structure;T cell response;T-Cell Activation;T-Lymphocyte;Techniques;Time;Tuberculoid leprosy

PROJECT_TITLE: CD1-restricted T-cell Responses in Skin

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases;Rare Diseases

ORG_DEPT: CHEMISTRY

ORG_NAME: SAN FRANCISCO STATE UNIVERSITY

PHR: Project Narrative: Penicillins are essential antibiotics for the resolution of gram-positive bacterial infections. The development of chemoenzymatic strategies for the green chemical synthesis of penicillin-class antibiotics can help to increase their availability and decrease the cost of production. In the present work we join the activities of an engineered aldehyde dehydrogenase from the bacterial styrene catabolic pathway and the fungal isopenicillanic acid N-acyltransferase to generate a new route for the synthesis of penicillins from 6-aminopenicillanic acid and aldehyde stating materials.

PI_NAMEs: GASSNER, GEORGE T. (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Acids;Active Sites;Acyl Coenzyme A;Acylation;Acyltransferase;aldehyde dehydrogenases;Aldehydes;amidase;amidation;Amino Acid Substitution;Amino Acids;Antibiotics;aptamer;Bacterial Meningitis;Biological Assay;C-terminal;Carboxylic Acids;catalase;chemical synthesis;Chemicals;Chemistry;Chimeric Proteins;Coenzyme A;Coenzyme A Ligases;cost;detection assay;Development;Disease;Engineering;Environmental Impact;Enzymes;Fermentation;Flavins;Fluorescence;fungus;Future;Gonorrhea;Gram-Positive Bacterial Infections;High Pressure Liquid Chromatography;Histidine;improved;In Vitro;Isomerase;Kinetics;Laboratories;Lactams;Ligase;Methods;Mixed Function Oxygenases;Monobactams;mutant;Mutation;Natural regeneration;novel strategies;Outcome;Oxidoreductase;Pathway interactions;Penicillins;Persons;Pharyngeal structure;phenylacetaldehyde;polypeptide;Preparation;Process;Production;Protein Engineering;prototype;Pseudomonas;pyridine nucleotide;Reaction;Recombinants;Resolution;Route;Side;Specificity;Structure;styrene oxide;Styrenes;Substrate Specificity;Sulfhydryl Compounds;Synthetic Genes;Syphilis;System;thioester;Transferase;United States;Work;Yaws

PROJECT_TITLE: Repurposing Styrene Catabolic Enzymes for the Synthesis of Penicillins


PHR: Project Narrative von Willebrand factor (vWF) is essential for normal hemostasis and thrombosis and is involved in other important processes such as angiogenesis and cancer cell metastasis. Regulated release of vWF depends on normal maturation of its storage granule, the Weibel-Palade bodies (WPBs), and subsequent fusion of WPBs to the plasma membrane, processes which are poorly understood. Using live cell microscopy, pulldown of endogenously tagged proteins, and a genetically modified mouse model, we propose to elucidate the endosomal pathway in WPB biogenesis, the associated trafficking machinery, and regulation of WPB exocytosis by the exocyst complex.

PI_NAMEs: SHARDA, ANISH VAIBHAV (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Adaptor Protein Complex 3;Adaptor Signaling Protein;Advisory Committees;Affect;Albinism;angiogenesis;Binding;Biogenesis;Blood;Blood Cells;Blood Coagulation Disorders;Blood Platelets;cancer cell;cardiovascular risk factor;Cardiovascular system;career;Cell membrane;Cells;cellubrevin;Clinical;Co-Immunoprecipitations;Coagulation Process;Complex;Cytoplasmic Granules;Data;Defect;Dependence;Disease;Docking;Endosomes;Endothelial Cells;Endothelium;Environment;Eukaryotic Cell;Exocytosis;experimental study;Fellowship;Five-Year Plans;fluidity;Gene Modified;Genes;Genetic Polymorphism;Goals;Growth;Hematology;Hemorrhage;Hemostatic Agents;Hemostatic function;Hermanski-Pudlak Syndrome;Human;Immunoprecipitation;Impairment;in vivo;Individual;innovation;Israel;live cell microscopy;Lysosomes;Mediating;Medical center;Melanosomes;Membrane;Membrane Protein Traffic;Mentors;Mentorship;Molecular;Molecular Weight;Morbidity - disease rate;mouse model;Neoplasm Metastasis;Organelles;Pathway interactions;Plasma;platelet function;Play;Postdoctoral Fellow;Process;protein complex;protein transport;Proteins;Qualifying;rab GTP-Binding Proteins;receptor;Regulation;release factor;Reporting;Research;Research Personnel;Role;Scientist;Secondary to;Secretory Vesicles;Skin Pigmentation;SNAP receptor;SNAP23 gene;syntaxin 3;Thrombosis;trafficking;Training;trans-Golgi Network;Vesicle;von Willebrand Disease;von Willebrand Factor;Weibel-Palade Bodies;Yeasts

PROJECT_TITLE: Molecular Mechanisms Underlying Endothelial Weibel-Palade Body Biogenesis and Exocytosis

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE The overall goal of the proposed research is to determine how common genetic variants and environmental risk factors predispose to the development, natural history, and phenotypic heterogeneity of idiopathic interstitial pneumonia (IIP) by establishing and prospectively evaluating a cohort of subjects at high-risk of familial interstitial pneumonia (FIP). Our proposed rare disease cohort focuses on a critical unmet public health need in interstitial pneumonia, to understand the etiology, natural history, and phenotypic heterogeneity of preclinical pulmonary fibrosis (PrePF), before the lung is scarred irreversibly.

PI_NAMEs: SCHWARTZ, DAVID ALBERT (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Ancillary Study;Automobile Driving;biobank;Biological;Biological Markers;case finding;Cicatrix;Classification;Clinical;Clinical assessments;clinical phenotype;clinically significant;cohort;Cohort Studies;Collaborations;Communities;Complex;Data;data warehouse;Databases;Development;Diagnosis;Diagnostic;Disease;Disease Progression;Dominant Genetic Conditions;Dose;drug development;Drug Targeting;Early Diagnosis;Enrollment;Environment;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;Etiology;Event;Family;Family history of;fibrotic lung;fibrotic lung disease;First Degree Relative;follow-up;gain of function;Genes;Genetic;Genetic Models;Genetic Risk;genetic risk factor;Genetic Transcription;genetic variant;Goals;Heterogeneity;high risk;high risk population;Idiopathic Interstitial Pneumonia;improved;Individual;interstitial;Interstitial Pneumonia;Intervention;Lung;Molecular;molecular phenotype;Monitor;MUC5B gene;National Heart, Lung, and Blood Institute;Natural History;Nested Case-Control Study;Observational Study;Onset of illness;Outcome;patient advocacy group;Patient Selection;Phenotype;Physiological;Physiology;Play;Pneumonia;Population;pre-clinical;preclinical development;Prediction of Response to Therapy;Predisposing Factor;Primary Prevention;prognostic;Program Development;programs;promoter;prospective;Protocols documentation;Public Health;Pulmonary Fibrosis;Questionnaires;radiological imaging;Random Allocation;Rare Diseases;Research;Risk;Risk Factors;Role;Sampling;Scanning;Secondary Prevention;Signs and Symptoms;Specimen;Standardization;study population;Subjects Selections;Symptoms;Testing;transcriptomics;Variant;Visit;Vital Status

PROJECT_TITLE: Preclinical Pulmonary Fibrosis, an opportune rare disease cohort


NIH_SPENDING_CATS: Biotechnology;Immunization;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative This proposal will provide a system for the scalable continuous evolution and computational design of antibodies against user-selected antigens. Antibodies are critical tools in medical research and are the basis for numerous therapies, but the generation of custom antibodies against new targets is a difficult and specialized task. The system proposed will turn antibody generation into a routine and widely accessible process for researchers in almost any field.

PI_NAMEs: KRUSE, ANDREW ;LIU, CHANG C (contact);MARKS, DEBORA S

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Acetylcholine;addiction;Affinity;Animals;Antibodies;Antibody Affinity;antibody engineering;Antibody Formation;antibody libraries;antigen binding;Antigen Presentation;Antigen Targeting;Antigen-Presenting Cells;Antigens;Architecture;Area;Back;Biogenic Amine Receptors;Biological Sciences;biomarker discovery;Biomedical Research;cancer therapy;Cell Surface Receptors;Cells;Central Nervous System;Chemistry;Clinic;Collection;Communities;cost;crowdsourcing;Custom;Cytometry;Data;Data Set;decision research;Democracy;design;Detergents;Diagnostic;Directed Molecular Evolution;Docking;Dopamine;Elements;empowerment;Engineering;epidemic response;Epinephrine;Evolution;experimental study;Explosion;follow-up;G-Protein-Coupled Receptors;Generations;generative models;Genes;Genetic;Histology;Human;Hybridomas;Image;Immune checkpoint inhibitor;Immune system;Immunization;Immunize;Immunoglobulin Fragments;Immunoprecipitation;improved;in vivo;innovation;insight;interest;Libraries;Machine Learning;machine learning algorithm;machine learning model;Medical Research;Medicine;Methods;Molecular;Molecular Biology;Molecular Conformation;Monoclonal Antibodies;nanobodies;Neurobiology;Neurosciences;Neurotransmitters;new technology;Nobel Prize;novel;Outcome;Pathogen detection;Phage Display;Pharmaceutical Preparations;Pheromone;Play;Process;Production;Productivity;Proliferating;Protein Engineering;Proteins;Proteome;Public Health;Reagent;receptor;Research;Research Personnel;response;Role;scaffold;Signal Transduction;Specificity;Speed;structural biology;Surface;System;Techniques;Testing;Therapeutic;tool;Training;Tube;Update;V(D)J Recombination;Western Blotting;Yeasts

PROJECT_TITLE: Making antibody generation rapid, scalable, and democratic through machine learning and continuous evolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BCMB-A(51)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE Opioid Use Disorder (OUD) is a chronic, relapsing disease characterized by compulsive drug seeking and use. This proposal addresses the need for better understanding of the neurocircuitry mediating opioid-motivated approach and avoidance behavior with a focus on groups of projection neurons that are differentially and selectively sensitive to activation by environmental contexts conditioned to morphine (a rewarding opioid) versus naloxone (an aversive opioid antagonist). From a translational perspective, this knowledge may aid in the development of novel treatment strategies acting selectively at signaling or molecular targets unique to opioid- sensitive functional neurons in the brain.

PI_NAMEs: NEDELESCU, HERMINA  (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Address;Affect;Amygdaloid structure;Anatomy;approach behavior;Area;Aversive Stimulus;avoidance behavior;Axon;Behavior;Behavior Control;Behavioral;Behavioral Model;Brain;Brain Diseases;Brain region;career;career development;Chronic;conditioned place preference;Data;Desire for food;Development;Development Plans;Drug Controls;Drug Modelings;drug of abuse;drug seeking behavior;Environment;Event;experience;Future;Genes;Glutamates;Goals;hippocampal pyramidal neuron;insight;Investigation;Knowledge;Laboratory Research;Learning;Link;Mediating;Mentors;Mentorship;Molecular;Molecular Target;Morphine;motivated behavior;Naloxone;neural circuit;Neurobiology;neurochemistry;Neurons;Neurosciences;novel;Nucleus Accumbens;Opioid;Opioid agonist;Opioid Antagonist;opioid use disorder;optogenetics;Output;Pathway interactions;Pattern;Pharmaceutical Preparations;Presynaptic Terminals;Process;programs;recruit;Recurrent disease;Relapse;Research;research and development;Research Design;response;Rewards;Role;Sensory Process;Signal Transduction;Site;skills;Source;Stimulus;success;System;Testing;tool;Training;transmission process;treatment strategy

PROJECT_TITLE: Control of opioid-motivated approach and avoidance behavior by neuronal ensembles in the basolateral amygdala and their projection targets in the nucleus accumbens

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Current treatments for addiction remain limited by gaps in the fundamental knowledge of how different regions of prefrontal cortex interact in decision-making. We will close a gap in the understanding of cognitive control in prefrontal cortex by studying effortful decision making with intracranial recordings and direct cortical stimulation in humans.

PI_NAMEs: HERMAN, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: addiction;Anterior;Back;Behavior;Behavioral;Biological Assay;Biological Markers;Brain;career;cingulate cortex;Code;Cognitive;cognitive control;cognitive process;cognitive reappraisal;Computer Models;cost;Cost Control;Cost Measures;Data;Decision Making;design;Development;Diffusion;discounting;Dissociation;Electrophysiology (science);Epilepsy;Etiology;experience;Experimental Psychiatry;experimental study;Foundations;Frequencies;Funding;Goals;Human;improved;indexing;Information Theory;innovation;Intervention;Intuition;K-Series Research Career Programs;Knowledge;Link;Maps;Measurement;Measures;Mediating;memory process;Methods;Modeling;Monitor;neural;neural correlate;neural model;neuroeconomics;neuromechanism;neurophysiology;Neurophysiology - biologic function;neuroregulation;novel;novel marker;Operative Surgical Procedures;Patients;Persons;Phase;Physiology;Play;Prefrontal Cortex;Process;Psychiatry;Randomized;Recovery;Research;Research Personnel;Resolution;Resource Allocation;Resources;Role;Short-Term Memory;Signal Transduction;skills;spatiotemporal;therapy development;Time;Training;Translating;Work

PROJECT_TITLE: Neural Basis of Effortful Decision Making

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Genetics

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: NARRATIVE Transcription is the first step in gene expression, is the most highly regulated step in gene expression, and is the target of two classes of current antibacterial drugs. Bacterial and archaeal transcription initiation and transcription elongation are well understood, but bacterial and archaeal transcription termination are only poorly understood. The proposed work will define the structural and mechanistic basis of the principal pathways of bacterial and archaeal transcription termination.

PI_NAMEs: EBRIGHT, RICHARD H. (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Anti-Bacterial Agents;antitermination;Archaea;Bacteria;Cleavage And Polyadenylation Specificity Factor;Complex;Cryoelectron Microscopy;deep sequencing;DNA;Endoribonucleases;Escherichia coli;Exoribonucleases;Gene Expression;Genetic Transcription;Invaded;Kinetics;mechanical force;Mediating;Modeling;nanopore;Pathway interactions;Pharmaceutical Preparations;Phase;protein protein interaction;Proteins;Regulation;Resolution;rho;RNA;single molecule;Structure;Testing;Thermococcus;Transcription Elongation;Transcription Initiation;transcription termination;Transcriptional Regulation;translocase;Work

PROJECT_TITLE: Prokaryotic Transcription Termination R37GM041376-R01GM041376 - Competitive Renewal Resubmission 1

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: HANOVER

ORG_DEPT: MISCELLANEOUS

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: NARRATIVE Motivated by soaring spending and stagnating life expectancy, the first 20 years of this PPG have focused on the causes and consequences of health care efficiency in the U.S. In this competitive renewal application, we respond to the NIA’s call to focus our research exclusively on persons with ADRD. While there are many forms of inefficiency in ADRD diagnosis, treatment, and care, we are interested primarily in inequity in care delivery as a form of inefficiency. We seek to advance knowledge regarding how the structural influences of state and federal policies, the organization and structure of health care services, and implicit and explicit biases in clinical decision-making influence medical and social care received by persons with ADRD, especially those from racialized and marginalized groups.

PI_NAMEs: BARNATO, AMBER E (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: access disparities;Accountability;acute care;Acute Disease;Adult;Affect;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Area;Asian population;Behavior;beneficiary;Black Populations;Budgets;burden of illness;care coordination;care delivery;care outcomes;Caring;Clinical;clinical decision-making;Clinical Services;Communities;community based service;COVID-19 prevalence;Data;data resource;Decision Making;Detection;Development;Diagnosis;Diagnostic tests;Disabled Persons;disease diagnosis;Disparity;Economic Burden;Eligibility Determination;end of life care;Equity;evidence base;Excess Mortality;experience;explicit bias;Exposure to;Face;falls;Family Caregiver;federal policy;Fee-for-Service Plans;Health;health care disparity;health care quality;health care service;health care service organization;health care service utilization;health disparity;health inequalities;Health Policy;Health Services;Health system;Healthcare;Healthcare Systems;Heterogeneity;Hispanic Populations;Home;home based service;Hospitals;Housing;implicit bias;improved;improved outcome;Individual;Inequity;innovation;Institution;Integrated Delivery Systems;Interdisciplinary Study;interest;Knowledge;lens;Life Expectancy;Link;Low income;marginalization;marginalized population;Marketing;Measures;Medicaid;Medical;Medicare;Methodology;Methods;Modeling;modifiable risk;novel;Nursing Homes;older adult;Outcome;Ownership;Patient Care;Patients;Pattern;payment;Perception;Persons;Physicians;point of care;Policies;practice factors;preference;Primary Care;primary care practice;Process;Productivity;Program Research Project Grants;Provider;Public Health;Quality of life;racial disparity;racial population;referral services;Research;Resources;Running;Sampling;Science;Seminal;service organization;Services;Shapes;social;social health determinants;Social support;Social Work;Source;Specialist;Structure;synergism;System;Testing;treatment and outcome;trend;Variant;Vulnerable Populations;Work

PROJECT_TITLE: Causes and Consequences of Healthcare Inequity in Alzheimer's Disease and Related Dementias


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

PROJECT_TERMS: Address;Adherence;Adult;Aging;Alzheimer's disease patient;Alzheimer's disease related dementia;Amber;American;Anthropology;Area;authority;Cardiovascular system;career development;Caring;Clinical;clinical care;Collaborations;Communication;Communities;community advisory board;Community Healthcare;Complement;Coordination and Collaboration;Data;data exchange;dementia care;Development;Discipline;Disparity;Economics;Elements;Engineering;Ensure;Equity;experience;Faculty;Family;Fostering;Funding;Future;Geography;Geriatrics;Gerontology;Goals;Grant;Health;health care delivery;health care disparity;health care service utilization;health equity;Health Policy;Healthcare;Human Resources;Indiana;Inequity;innovation;Institution;intersectionality;Intervention;Investments;Journals;Knowledge;Leadership;Machine Learning;marginalized population;Medicaid;Medical;Medicare;meetings;member;Methods;outcome disparities;Palliative Care;Patients;Peer Review;Pilot Projects;Policies;Primary Care;Principal Investigator;Productivity;Program Research Project Grants;Provider;Public Health;Publications;racial population;Reproducibility;Research;research and development;Research Personnel;Research Support;Resources;Scientist;Seminal;Services;social;Social Work;Sociology;statistics;Structure;symposium;synergism;System;Telemedicine;Touch sensation;United States National Institutes of Health;Universities;Variant;web site;Work;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Social Determinants of Health

PI_NAMEs: ALFORD-TEASTER, JENNIFER A (contact)

PROJECT_TERMS: administrative database;Algorithms;Alzheimer's disease related dementia;Alzheimer's disease risk;Caliber;Catalogs;Censuses;Clinical;Code;cohort;Collaborations;collaborative environment;Communities;County;Data;Data Analyses;Data Analytics;Data Collection;data curation;data de-identification;data management;data repository;Data Set;data visualization;Databases;design;Development;Enrollment;Ensure;Evaluation;experience;Fostering;Future;Generations;Geography;Goals;Grant;Guidelines;health care delivery;health care disparity;health care service;health care service utilization;heterogenous data;Human Resources;Individual;Inequity;Interview;Lead;Leadership;Learning;Libraries;Link;Manuscripts;Measures;Medicare claim;Medicare/Medicaid;Methodology;Methods;novel;Output;Pattern;Persons;Phase;Policies;Postdoctoral Fellow;Procedures;Production;Program Research Project Grants;programs;Records;repository;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resource Sharing;Resources;Rest;Rural;Sampling;Secure;Source;Standardization;Structure;structured data;synergism;Testing;Validation;Variant;Visual;Work

PROJECT_TITLE: Data Management Core B


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Inflammatory Bowel Disease;Microbiome;Obesity

ORG_DEPT: GENETICS

PHR: Project Narrative This proposal will focus on a family of of intracellular innate immune receptors that we first described and their profound impact on cancers. We will explore their roles in myriad modes of cancer suppression or exacerbation including those associated with inflammation and obesity. In addition, we will explore the trio network of innate immunity, microbiome and cancer, and explore ways to utilize these interactions to improve anti-cancer immunotherapy.

PI_NAMEs: TING, JENNY P (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: adaptive immunity;Address;Advanced Malignant Neoplasm;Affect;Animals;Anti-Inflammatory Agents;Binding;cancer immunotherapy;Cancer Model;cancer therapy;Cells;Chronic;Colitis;Colitis associated colorectal cancer;Colorectal Cancer;combat;Complex;Crohn's disease;Family;Family member;Foundations;Gene Family;Genetic;genetic association;Goals;gut homeostasis;gut microbiome;Human;Immune;Immunologic Receptors;Immunotherapy;improved;Inflammasome;Inflammation;Inflammatory Bowel Diseases;Leucine-Rich Repeat;Link;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;member;metaplastic cell transformation;microbial products;microbiome;Modeling;Molecular;mouse model;Mus;Natural Immunity;novel strategies;Nucleotides;Obesity;Pattern;Predisposing Factor;Proteins;receptor;Recording of previous events;Resistance;Risk Factors;Role;Translating

PROJECT_TITLE: Intracellular Innate Immune Receptors in Cancer Suppression and Immunotherapy


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Rare Diseases;Usher Syndrome

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: The mammalian auditory organ harbors two types of sensory cells called inner and outer hair cells. We made the unexpected and novel discovery that each cochlear cell type preferentially expresses a distinct isoform of the deafness gene Myosin VIIa (MYO7A). We hypothesize that intrinsic differences of the two MYO7A isoforms significantly influence the functional output of the two hair cell types. This project has the potential to reveal the molecular mechanisms underlying the functional specialization of different hair cell types, and will contribute fundamentally to our understanding of hearing and deafness.

PI_NAMEs: SHIN, JUNG-BUM  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Address;Affect;Ankle;Apical;Auditory;Binding;Biochemistry;Cell Physiology;cell type;Cells;Cellular Morphology;Cochlea;Complex;deafness;Development;differential expression;Electrophysiology (science);Endowment;Exhibits;experimental study;Genes;Genetic;Genetically Engineered Mouse;Hair;Hair Cells;Hearing;Hearing Tests;Image;Inner Hair Cells;insight;Interdisciplinary Study;Knock-in Mouse;Link;Liquid substance;Measurement;Measures;Mechanics;mechanotransduction;Modeling;Molecular;Morphology;Motor;mouse model;Mus;Mutation;MYO7A gene;Myosin ATPase;novel;Organ;Outer Hair Cells;Output;Pattern;Performance;Probability;progressive hearing loss;Property;Protein Isoforms;Proteins;Reporting;response;Rest;Role;Sensory;Sensory Hair;Severities;Site;Techniques;Testing;Time;tool;Transcript;Usher Syndrome Type 1

PROJECT_TITLE: Significance of Myo7a isoforms in hair cell function

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: O'MALLEY, ALISTAIR JAMES (contact)

PROJECT_TERMS: Accounting;Address;Affect;algorithmic bias;Alzheimer's disease care;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Area;Assisted Living Facilities;Attention;Automation;care outcomes;Caring;Chronology;Collaborations;Communities;community based service;Comparative Effectiveness Research;complex data;Computer software;Computing Methodologies;Data;Data Analytics;Death Rate;dementia care;Detection;Development;Diagnosis;Diagnostic;Diagnostic Procedure;Diagnostic tests;Disease;Disparity;electric impedance;Environment;Experimental Designs;Goals;Health;health care availability;health care disparity;health disparity;health inequalities;Health Personnel;Health Services Accessibility;Health system;Healthcare;Heterogeneity;Home;Hospitals;Human Resources;improved;Inequity;innovation;insight;interest;Link;Machine Learning;machine learning algorithm;Measurement;Measures;Medical;medical specialties;Medicare claim;member;Methods;Minority;Modeling;network models;Network-based;Neurologist;novel;Nursing Homes;Outcome;Output;Pathway Analysis;patient population;patient responsibilities;Patient-Focused Outcomes;Patients;Persons;Physicians;Provider;provider networks;Quality of Care;Race;Research;Research Design;Risk;Risk Factors;rurality;Secure;Services;sex;socioeconomic disparity;Specialist;Statistical Methods;Statistical Models;statistics;Structure;synergism;Time;trend;Variant;Work

PROJECT_TITLE: Methods Core C


NIH_SPENDING_CATS: Cannabidiol Research;Cannabinoid Research;Cerebrovascular;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Natural Products;Neurosciences;Substance Misuse

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE Addictive drugs, including cannabis, can alter the structure and function of the blood-brain barrier (BBB), which helps protect the brain from the adverse effects of inflammation. These changes influence the risk for cognitive and mood disorders, particularly among vulnerable people with HIV. This project aims to combine multidisciplinary observational and mechanistic data to determine how cannabis and HIV combine to affect the BBB, inflammation, and the brain, which should provide valuable insights into the mechanisms underlying these relationships that may lead to new therapies and reduce the public health impact of these conditions.

PI_NAMEs: FIELDS, JEREL ADAM;IUDICELLO, JENNIFER E (contact);MARCONDES, MARIA CECILIA GARIBALDI

PROGRAM_OFFICER_NAME: MCCLURE-BEGLEY, TRISTAN DAVID

PROJECT_TERMS: 3-Dimensional;Adhesions;Adverse effects;Affect;Agonist;antagonist;Anti-Inflammatory Agents;antiretroviral therapy;Astrocytes;Biological Markers;Biology;biomarker panel;Blood;Blood - brain barrier anatomy;blood-brain barrier function;blood-brain barrier permeabilization;Brain;Cannabidiol;cannabinoid receptor;Cannabinoids;Cannabis;cannabis use behavior;Cardiovascular Diseases;Cell Adhesion Molecules;Cells;Central Nervous System;Cerebral endothelium;Cerebrospinal Fluid;Chronic;Clinical;Cognition Disorders;cohort;Cytoskeleton;Data;Diffusion Magnetic Resonance Imaging;DNA;Dose;Endocannabinoids;Endothelial Cells;Endothelium;Etiology;Extravasation;Frequencies;Future;Gene Expression;General Population;Genetic Markers;HIV;HIV Infections;Homeostasis;Image;imaging modality;improved;In Vitro;in vitro Model;in vivo;Individual;Individual Differences;Infection;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;Injury;innovation;insight;Interdisciplinary Study;Investigation;knowledge translation;Leukocytes;Link;Macrophage;marijuana use;Measures;Metabolic;Microfluidics;Microglia;migration;Mitochondria;mitochondrial dysfunction;Modeling;monocyte;Mood Disorders;multidisciplinary;multimodality;Nervous System Trauma;Neurocognitive;Neurocognitive Deficit;Neuroglia;neuroimaging;Neurons;Neurotoxins;novel therapeutics;Observational Study;Outcome;Oxidative Phosphorylation;Participant;Pathogenesis;Pathogenicity;Patients;Pattern;Pericytes;Permeability;Persons;Pharmaceutical Preparations;Plants;Plasma;pre-clinical;Pre-Clinical Model;Property;Proteins;Public Health;receptor binding;recruit;Research;research clinical testing;Research Proposals;response;Risk;RNA;Role;Route;Structure;Substance abuse problem;substance use;Techniques;Technology;Testing;Tetrahydrocannabinol;Therapeutic Intervention;Tight Junctions;Toxic effect;Variant;Viral;Virus Replication;Vulnerable Populations

PROJECT_TITLE: Cannabis and Pathogenic Mechanisms influencing Blood Brain Barrier Function in HIV


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Climate-Related Exposures and Conditions;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Air pollution exposure is a well-established risk factor for many health conditions including dementia. Yet, how air pollution affects dementia is poorly understood. Here, we aim determine the role of air pollution on two of the most common causes of dementia, namely Alzheimer's disease and vascular cognitive impairment, using well-characterized diverse longitudinal studies of brain aging that will provide biological insights and identify characteristics for people at higher risk (e.g., sex and race/ethnicity).

PI_NAMEs: HUELS, ANKE  (contact);WINGO, THOMAS SPURGEON

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: accelerated epigenetic aging;Address;Affect;African American;Age;Aging;aging brain;Air Pollution;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;ambient air pollution;Amyloid beta-42;apolipoprotein E-4;Biological;Biological Markers;Blood;Blood Vessels;Brain;brain health;brain magnetic resonance imaging;Cardiovascular Diseases;Cerebrospinal Fluid;Cerebrovascular Disorders;Cerebrum;Characteristics;Chronic Disease;Clinical;Cognition;Cognitive;cohort;comorbidity;Confounding Factors (Epidemiology);Cross-Sectional Studies;Data;Dementia;dementia risk;design;Diabetes Mellitus;DNA Methylation;Ethnic Origin;executive function;Exposure to;Female;fine particles;Genetic;Genetic Risk;Health;healthy aging;high risk;Hippocampus;Hypertension;Image;Impaired cognition;Impairment;Individual;insight;Ischemia;Knowledge;language impairment;Link;Longitudinal Studies;low socioeconomic status;Measures;Mediating;Medical;Memory;Memory impairment;Mental Depression;methylation pattern;modifiable risk;Modification;neighborhood disadvantage;Nerve Degeneration;Nervous System;neurocognitive test;Observational Study;older adult;Olfactory Nerve;Participant;Persons;programs;Psychological Factors;Race;racial diversity;recruit;Research;Resolution;Risk;Risk Factors;Role;sex;Short-Term Memory;social;Socioeconomic Factors;Socioeconomic Status;Stress;Symptoms;systemic inflammatory response;tau Proteins;tau-1;Testing;United States Environmental Protection Agency;Vascular Cognitive Impairment;Work

PROJECT_TITLE: Air pollution and early signs of dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Acceleration;acute care;Address;Administrator;Adoption;Adult;Adverse event;Affect;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;American;beneficiary;Black Populations;Black race;care delivery;care outcomes;Caregivers;Caring;Clinical;Collaborations;Communities;community based service;community setting;community-level factor;Complex;cost;court;Data;Data Reporting;Decision Making;design;Diagnosis;disability;Disability status;Disabled Persons;Discipline of Nursing;Disparity;disparity reduction;dual eligible;Eligibility Determination;end of life care;Equity;Ethnic Origin;Evaluation;Event;Family;federal policy;Funding;Goals;Government Financing;health care disparity;Health care facility;Hispanic;Hispanic Populations;Home;Home Nursing Care;Hospitalization;improved;Individual;Inequity;informant;Institution;Institutionalization;interest;Interview;Investments;Link;longitudinal analysis;marginalized population;Medicaid;Medical;Medicare;Medicare/Medicaid;Methods;Modeling;Morbidity - disease rate;mortality;Nursing Homes;Outcome;pandemic disease;Patient Care;Patient Self-Report;Patients;payment;person centered;Persons;Policies;preference;Primary Care;Process;Program Research Project Grants;programs;Quality of Care;Quality of life;Race;racial disparity;racial population;recruit;response;Risk;Sampling;service delivery;service providers;Services;social;Social outcome;Surveys;synergism;System;Testing;uptake;Waiting Lists;waiver;welfare;Work

PROJECT_TITLE: Inequities in Home and Community-Based Services Access and Disparities in Alzheimer's Disease and Related Dementias


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cardiovascular;Clinical Research;Contraception/Reproduction;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Women's Health Research

ORG_CITY: CINCINNATI

ORG_NAME: THE CHRIST HOSPITAL

ORG_STATE: OH

PHR: PROJECT NARRATIVE Despite the substantial cardiovascular risk burden associated with the development pregnancy related- hypertensive disorders, surprisingly little is known regarding the mechanisms that drive the development of these hypertensive disorders of pregnancy in some women or the subsequent cardiovascular disease (CVD) outcomes in these vulnerable women. We hypothesize that: (i) the stress of pregnancy augments pre-existing metabolic and inflammatory derangements in certain women, making them more susceptible to hypertensive disorders of pregnancy; (ii) in this setting, affected women are prone to developing coronary microvascular dysfunction (CMD), a previously unrecognized driver of CVD risk; and, (iii) women affected by a hypertensive disorder of pregnancy, especially in the setting of pre-existing metabolic and inflammatory risk and CMD, are more likely to experience accelerated subclinical cardiac disease and progression to clinical CVD. To test our hypotheses and determine mechanisms by which certain women are made vulnerable to hypertensive disorders of pregnancy and subsequent CVD, we will comprehensively interrogate the clinical, biochemical, and physiological determinants of pregnancy-associated CVD risk in both a community cohort enriched with cardiometabolic traits and a clinical cohort that is deeply phenotyped using advanced non-invasive cardiovascular imaging.

PI_NAMEs: QUESADA, ODAYME  (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Acceleration;Adult;Affect;Age;aged;Award;Biochemical;Cardiac;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular imaging;cardiovascular risk factor;Cardiovascular system;career development;case control;Cicatrix;Clinical;Clinical Investigator;clinical translation;cohort;Communities;Conceptions;Coronary;Coronary Arteriosclerosis;coronary fibrosis;Data;design;Development;Diagnostic;Disease Outcome;Echocardiography;Endothelium;Epidemiology;Etiology;Event;Exhibits;experience;Functional disorder;Future;Goals;Heart Abnormalities;Heart Diseases;Heart failure;heart imaging;Heterogeneity;high risk;Hispanic Community Health Study/Study of Latinos;Hispanic Women;Hypertension;Impaired fasting glycaemia;indexing;Inflammation;Inflammatory;inflammatory marker;Investigation;Knowledge;Magnetic Resonance;Measures;Mediating;men;Metabolic;Metabolic syndrome;Microvascular Dysfunction;Mission;Modeling;mortality;normotensive;Outcome;Oxidative Stress;Participant;Pathway interactions;perfusion imaging;Phenotype;Physiological;Population;Population Sciences;Pre-Eclampsia;Predisposition;Pregnancy;Pregnancy Complications;pregnancy disorder;pregnancy hypertension;Pregnancy Interval;Program Development;prospective;Recording of previous events;recruit;Reporting;Research;Risk;Risk Factors;sex;Sex Differences;Site;skill acquisition;Stress;Structure;Testing;Time;Training;trait;United States National Institutes of Health;Visit;Woman;Women's Health

PROJECT_TITLE: Hypertensive Disorders of Pregnancy: Pathways to Future Cardiovascular Disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]