ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Social Determinants of Health;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Transgender and gender diverse (TGD) individuals are often diagnosed with late-stage cancer and often die from cancer prematurely. These individuals appear to be underscreened for breast cancer at rates and for reasons that are unknown. This K23 application will enable the principal investigator to investigate these rates and reasons; to learn from her 6 senior mentors; to take necessary coursework; and ultimately to emerge as a national leader with the goal of helping TGD individuals acquire equity in cancer screening and cancer care.

PI_NAMEs: CATHCART-RAKE, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: LAI, GABRIEL Y

PROJECT_TERMS: Adherence;Adopted;Age;Age Years;assigned female at birth;assigned male at birth;Benchmarking;Bilateral;Breast;Breast Cancer Detection;Breast Cancer Early Detection;cancer care;cancer diagnosis;career development;Caring;Categories;Cessation of life;cis-female;cisgender;Clinic;clinically relevant;Code;cohort;comparative;Data;data warehouse;Databases;Dedications;Diagnosis;Discrimination;Disease Outcome;Disparity;Documentation;Drug Prescriptions;Eligibility Determination;Endocrinologist;Epidemiologist;Equity;experience;falls;Female;Feminization;forging;Fright;Future;Gender;gender affirmation;gender diverse;gender dysphoria;gender transition;General Population;Goals;health care disparity;health inequalities;Health Personnel;high risk;hormone therapy;Hormones;improved;Individual;Institution;insurance claims;interest;International;intersectionality;Intersex;Intervention;Interview;Learning;Life;male;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammographic screening;Mammography;Mastectomy;Medical Oncologist;medical specialties;medically underserved;Mentors;minority patient;Modeling;multidisciplinary;nonbinary;Office Visits;Operative Surgical Procedures;Organ;Outcome;Outpatients;Pan American Health Organization;Patients;Perception;Persons;Pharmacy facility;Population;Population Heterogeneity;Positioning Attribute;premature;Primary Care Physician;Principal Investigator;prospective;Qualitative Methods;recruit;Reporting;Research;Research Personnel;Sampling;screening;Screening for cancer;Screening procedure;Services;Sexual and Gender Minorities;skills;sound;Testing;Thinking;transfeminine;transgender;transgender men;transgender women;transmasculine;Trust;Underserved Population;United States;Visit;Writing

PROJECT_TITLE: Cancer Screening Mammography in Transgender and Gender Diverse (TGD) Individuals

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (M2)]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Physical Activity;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN LUIS OBISPO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_NAME: CALIFORNIA POLY STATE U SAN LUIS OBISPO

ORG_STATE: CA

PHR: Project Narrative Cardiovascular disease (CVD) is a leading cause of death in the US. Obesity in mothers and children is linked with nearly every major CVD risk factor, including hypertension, elevated glucose, high cholesterol, poor diet, and physical inactivity. This research will test an empirically validated pre- and postnatal lifestyle intervention within an evidence-based home visiting program to improve cardiovascular health in Hispanic and non- Hispanic women and children during pregnancy and postpartum.

PI_NAMEs: PARADE, STEPHANIE HART;PHELAN, SUZANNE  (contact);WING, RENA R

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Accounting;Adherence;Affect;Ancillary Study;Behavior;black women;Blood Pressure;Body mass index;Body Weight;Body Weight decreased;Breast Feeding;burnout;California;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cause of Death;Child;Cholesterol;clinically significant;cohort;design;Development;Diabetes Mellitus;Diet;early childhood;Early Intervention;effectiveness evaluation;effectiveness testing;effectiveness/implementation trial;empowerment;evidence base;experience;Family;family support;feeding;Funding;Future;gestational weight gain;Glucose;Goals;Health behavior;health of the mother;Health Personnel;Heart;Hispanic;Hispanic Women;Home;Home environment;Home visitation;Hybrids;Hypertension;improved;infancy;Infant;innovation;Intervention;Life;lifestyle intervention;Link;Low income;low socioeconomic status;Maternal and Child Health;maternal obesity;maternal weight;Measures;Mediator;medication compliance;Modeling;modifiable risk;Mothers;Not Hispanic or Latino;Obesity;obesity prevention;online delivery;Overweight;perinatal women;Phase;physical inactivity;Positioning Attribute;postnatal;Postpartum Period;postpartum weight;Pregnancy;Pregnancy Complications;prenatal;Prevalence;prevent;programs;Protocols documentation;Quality of life;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;remote delivery;Research;Research Design;Research Personnel;Resources;Rhode Island;Risk;Risk Factors;sedentary;Series;Site;skills;Sleep;social health determinants;Social support;Spanish/English;Target Populations;Telephone;Testing;Time;Triglycerides;tv watching;underserved community;Unhealthy Diet;United States National Institutes of Health;waist circumference;Woman;Women's mortality;Work

PROJECT_TITLE: Healthy Hearts/ Corazones Saludables: Partnership to promote cardiovascular health in Hispanic and non-Hispanic mothers and children in US home visiting programs


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: LA JOLLA

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative High- and low-level computations for coordination of orofacial motor actions Neuronal circuits in the brainstem control life-sustaining functions, including breathing and other rhythmic orofacial motor actions that underlie both exploration and consumption, and that must be performed without interruption from the moment of birth. Our hypothesis is that high-level rhythmic signals modulate the phase of low-level rhythmic activity on a cycle-wise basis, and high-level broadband signals regulate both set-point and posture to form coordinated and precise rhythmic behaviors. Guided by our hypothesis, we use and advance the tools of modern neuroscience to add informative labels to individual neurons in the brainstem, place these cells within circuits, connect circuits with motor actions, and coordinate different actions into behaviors.

PI_NAMEs: ECONOMO, MICHAEL NICHOLAS;GOLOMB, DAVID ;KLEINFELD, DAVID  (contact);O'CONNOR, DANIEL HANS;WANG, FAN

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-P (13)]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Neurosciences;Substance Misuse

PI_NAMEs: KLEINFELD, DAVID  (contact)

PROJECT_TERMS: Address;Animals;Basal Ganglia;Behavior;Biological;Brain Stem;Breathing;Cells;Cerebellar Nuclei;Consumption;Coupled;Data;Esthesia;experience;Experimental Designs;extracellular;Feedback;feeding;Goals;Head;Head Movements;Image;Individual;insight;interest;Label;Lead;Mastication;Midbrain structure;Modeling;molecular phenotype;Motor;Motor Cortex;Motor Neurons;Movement;Mus;Nature;Neurons;Nose;Optics;orofacial;Output;Periodicity;Phase;Plants;preBotzinger complex;promoter;Prosencephalon;Rattus;Reflex action;Rewards;Rodent;Role;Running;sensor;Sensory;sensory cortex;Signal Pathway;Signal Transduction;Smell Perception;Structure of trigeminal nerve spinal tract nucleus;superior colliculus Corpora quadrigemina;Synapses;synergism;System;Testing;Theoretical model;theories;Tongue;Touch sensation;Training;Vibrissae

PROJECT_TITLE: Confluence of high- and low-level signaling for the control of orofacial rhythmic motor actions


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Bioengineering;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Neurosciences;Rehabilitation;Substance Misuse

PI_NAMEs: GOLOMB, DAVID  (contact)

PROJECT_TERMS: Address;Affect;Anatomy;Animals;Area;arm;Behavior;biomechanical model;Biomechanics;Biophysics;Blood Vessels;Brain;Brain Stem;Breathing;Cell Nucleus;chemical property;Code;Computational Technique;Consumption;Coupled;Coupling;Data;Distal;Elasticity;electrical property;Elements;experimental group;experimental study;Face;Facial motor nucleus;Feedback;Ganglia;Generations;Goals;Head;Hydromorphone;insight;Jaw;kinematics;Laboratories;Lead;Location;Mastication;member;Modeling;Motor;Motor Activity;motor control;Motor Cortex;Motor Neurons;Movement;Muscle;Neurologic;neuronal circuitry;Neurons;Octopus;Organ;orofacial;Pattern;Plants;Positioning Attribute;preBotzinger complex;predictive modeling;programs;Property;Psychological Techniques;Rattus;response;Rod;Rodent;Rotation;Sense Organs;sensor;Sensory;sensory feedback;sensory input;Shapes;Signal Transduction;Spinal;superior colliculus Corpora quadrigemina;Synapses;System;theories;three-dimensional modeling;Tongue;Torque;Touch sensation;Translations;Trigeminal System;two-dimensional;Vascularization;Vibrissae;Work

PROJECT_TITLE: The shape, movement, and signals of active sensors: Modeling the biomechanics of deformable orofacial organs


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Neurosciences;Substance Misuse;Temporomandibular Muscle/Joint Disorder (TMJD)

PI_NAMEs: WANG, FAN  (contact)

PROJECT_TERMS: 3-Dimensional;Ablation;Anatomy;Axon;Behavior;biomechanical model;Blood flow;Brain Stem;Breathing;Cells;Collaborations;Data;Dorsal;Electrophysiology (science);expiration;feeding;Feeding behaviors;flexibility;Frequencies;genetic approach;Goals;in vivo;Jaw;jaw movement;kinematics;Label;Lead;Location;Mammals;Mastication;Mechanics;Methods;Modeling;Molecular;Motor;Motor Neurons;Movement;Muscle Tonus;nerve supply;neural;neuromechanism;Neurons;novel;Oral cavity;orofacial;parvocellular;Pattern;Periodicity;Physiological;Physiology;Play;Population;Reticular Formation;Rodent;Role;Shapes;Signal Transduction;Synapses;Techniques;Testing;Thinking;Tongue;Trigeminal System;Vascular Smooth Muscle;virus genetics

PROJECT_TITLE: Identifying brainstem oscillators and other low-level mechanisms controlling tongue and jaw movements


PI_NAMEs: ECONOMO, MICHAEL NICHOLAS (contact)

PROJECT_TERMS: Address;Anatomy;Animals;Anterolateral;Architecture;Area;Axon;Behavior;Behavioral;Brain;Brain imaging;Brain region;Brain Stem;Breathing;Cell Nucleus;cell type;Cells;Communication;Complement;Complex;Consumption;Costs and Benefits;Dissection;Dorsal;Elements;experience;experimental study;flexibility;Fluorescent in Situ Hybridization;food consumption;Goals;high throughput technology;Individual;Investigation;Jaw;jaw movement;Label;Lead;Learning;Locomotion;Logic;Maps;Modeling;Molecular;Morphology;Motor;Motor Neurons;Movement;Mus;Muscle;Neuroanatomy;Neurons;novel;orofacial;Output;Pathway interactions;Pattern;Physiology;presynaptic;Proprioception;Rabies virus;reconstruction;Respiration;Reticular Formation;Role;sensory feedback;Shapes;Signal Transduction;single cell technology;Spatial Distribution;Spinal Cord;Structure;superior colliculus Corpora quadrigemina;Synapses;System;Time;Tongue;tool;transcriptomics;transmission process;Trigeminal Nuclei;virus genetics;Water;Work

PROJECT_TITLE: Neuroanatomical and molecular architecture of high- and low-level circuits controlling orofacial movements


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Neurosciences;Substance Misuse

PI_NAMEs: O'CONNOR, DANIEL HANS (contact)

PROJECT_TITLE: Top-down and bottom-up signals for flexible orofacial behaviors


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Substance Misuse

PROJECT_TERMS: adaptive optics;Advisory Committees;Agreement;Anatomy;Animals;awake;Behavior;Boston;Brain;Budgets;computer science;Consultations;Contracts;Data;Data Analyses;Data Science Core;data sharing;design;Development;Doctor of Philosophy;Electrophysiology (science);Ensure;experience;experimental study;Funding;genetic manipulation;Goals;Grant;Histology;Human Resources;Image;in vivo;in vivo optical imaging;Lead;Leadership;Link;meetings;member;Motor;Neurons;orofacial;Persons;Physics;Postbaccalaureate;professor;programs;Regulation;Research Personnel;Resources;Services;Site;summer research;two photon microscopy;Underrepresented Minority;United States National Institutes of Health;Update;videoconference;Virus

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Data Science;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Neurosciences;Substance Misuse

PI_NAMEs: PREVOSTO, VINCENT  (contact)

PROJECT_TERMS: Collaborations;computerized data processing;Data;Data Analyses;data analysis pipeline;data exchange;data management;data repository;data reuse;Data Science;Data Science Core;Data Set;data sharing;data tools;data visualization;database query;Ensure;Guidelines;Infrastructure;Lead;Motor;orofacial;performance site;Process;Publications;repository;Reproducibility;Research;Research Personnel;Secure;web portal

PROJECT_TITLE: Data Science Core


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Bioengineering;Biomedical Imaging;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Neurosciences;Substance Misuse

PI_NAMEs: FRIEDMAN, BETH  (contact)

PROJECT_TERMS: 3-Dimensional;Address;analysis pipeline;anatomic imaging;Anatomy;annotation  system;Atlases;Automation;Axon;Behavior;Brain;Brain imaging;Brain Mapping;Brain Stem;Cells;Collaborations;Data;data ingestion;Data Science Core;Data Set;density;Distal;Electrodes;Electrophysiology (science);experimental study;Feedback;Histology;Image;image visualization;improved;Individual;Label;Laboratories;Lead;Light;Lighting;Maps;Methodology;Methods;Microscopy;Motor;Motor Neurons;Movement;multi-electrode arrays;Mus;Muscle;Neighborhoods;Neuroanatomy;Neurons;open source;orofacial;Output;Pathway interactions;peer;Peer Review;peer support;performance site;Peripheral;Population;Population Control;Publications;reconstruction;Regulation;Research Personnel;Resolution;Reverse engineering;Running;Sampling;Shapes;Silicon;Site;Skeleton;Structure;success;support tools;Synapses;Techniques;Time;tool;virus genetics;Visualization;web platform;web-accessible

PROJECT_TITLE: Quantitative Neuroanatomy


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Bioengineering;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Neurosciences;Substance Misuse

PI_NAMEs: LIU, RUI  (contact)

PROJECT_TERMS: adaptive optics;Brain Stem;brain tissue;Cell Physiology;cellular imaging;Collaborations;Custom;Fiber;Functional Imaging;Funding;Goals;Image;in vivo;Laser Scanning Microscopy;Lasers;Lead;Maintenance;meter;Microscope;Motor;Motor Cortex;multi-photon;neuronal circuitry;optogenetics;orofacial;Parents;Penetration;performance site;Research Personnel;Resolution;Site;Structure;superior colliculus Corpora quadrigemina;synaptic function;System;Techniques;Technology;Tissues;Training;Travel;two-photon;white matter

PROJECT_TITLE: Advanced Nonlinear Imaging


ADMINISTERING_IC: TR

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: Columbus

ORG_DEPT: PSYCHIATRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative: This institutional training grant will train early career faculty at the Ohio State University and Nationwide Children’s Hospital. The goal is to develop individualized plans and comprehensively train faculty to participate in and then lead in clinical and translational research, to ultimately improve human health for all.

PI_NAMEs: CARNES, CYNTHIA A;PHAN, K. LUAN  (contact)

PROGRAM_OFFICER_NAME: CURE, PABLO

PROJECT_TERMS: Appointment;career;Career Mobility;Characteristics;clinical center;Clinical Research;Clinical Sciences;clinical translation;Communication;Communities;Data Analyses;Dedications;Development;diversity and inclusion;early-career faculty;Elements;Eligibility Determination;Environment;equity, diversity, and inclusion;Evaluation;experience;Faculty;Fostering;Funding;Future;Goals;Grant;improved;Individual;innovation;Institution;Lead;Leadership;life span;Logic;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Modeling;Monitor;Ohio;Outcome;Participant;Pediatric Hospitals;Preparation;Productivity;Program Evaluation;programs;Publications;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reproducibility;Research;Research Design;Research Ethics;Research Personnel;responsible research conduct;rural patients;Science;Scientist;skill acquisition;Structure;suburb;success;Training;Translational Research;translational scientist;Universities;Writing

PROJECT_TITLE: CTSA K12 Program at The Ohio State University

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-7 (01)]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Stroke

ORG_CITY: CINCINNATI

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: This Japan-US workshop entitled “Making Acute Stroke Trials Succeed: Challenges and Potential Solutions” has two goals: 1) To exchange information about the opportunities and barriers to conduct collaborative stroke clinical trials that are innovative in design, patient- centered, and pragmatic; 2) To explore the use of emergency consent procedures, and other innovative methods to facilitate enrollment in acute stroke trials in Japan and the U.S. The workshop can be viewed as an accelerator of patient-centered global collaborative trials and a facilitator of enrollment using emergency consent procedures in Japan.

PI_NAMEs: BRODERICK, JOSEPH PAUL (contact);ELM, JORDAN J.;GROTTA, JAMES C;NAIDECH, ANDREW M

PROGRAM_OFFICER_NAME: AFZAL, MARIAM MASHEEB

PROJECT_TERMS: Acute;acute stroke;Address;Anti-Hypertensive Agents;Brain hemorrhage;brain research;Cardiovascular system;Cerebral hemisphere hemorrhage;Clinical;Clinical Trials;Collaborations;collaborative trial;Consent;Country;Dedications;design;Educational workshop;Emergency Situation;Enrollment;Future;Goals;Informed Consent;innovation;International;Japan;Japanese;Knowledge;Methodology;Methods;National Institute of Neurological Disorders and Stroke;Outcome;Participant;Pathway interactions;Patient Care Management;patient oriented;Patient-Focused Outcomes;pragmatic trial;Procedures;programs;recombinant FVIIa;Research Personnel;Resources;Stroke;stroke clinical trials;stroke therapy;stroke trials;Surveys;System;Time;trial design;working group


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: GREENVILLE

ORG_DEPT: SURGERY

ORG_NAME: EAST CAROLINA UNIVERSITY

ORG_STATE: NC

PHR: Narrative East ethnically RACING assessment barriers, vertical  Carolina University has a longstanding mission to serve rural eastern North Carolina, a racially and  diverse region with significant health disparities and adverse social determinants of health. This AHEAD project will identify gaps in health disparities research capacity through an institutional needs and develop an action plan for improvement. By leveraging existing strengths, reducing identified and building a supportive infrastructure and transdisciplinary community, the action plan will catalyze a growth in extramural biomedical research funding to advance health equity in our region.

PI_NAMEs: VERBANAC, KATHRYN M. (contact);ZHOU, YING

PROGRAM_OFFICER_NAME: HOLMES, ANGELA L

PROJECT_TERMS: academic preparation;Active Learning;Address;Articulation;Arts;aspirate;Award;Awareness;Basic Science;Big Data;Biomedical Research;career development;Classification;Clinical;Clinical Research;Collaborations;college;Communities;community research;Data;Decision Making;design;Development Plans;Discipline;Disparity;Distress;Economics;Environment;ethnic diversity;Ethnic Origin;evidence base;expectation;Expenditure;Extramural Activities;Faculty;faculty community;faculty research;Feedback;Focus Groups;Fostering;Funding;Goals;Grant;Growth;Health;health care availability;Health Disparities Research;health disparity;health equity;Health Professional;Hospitals;Human Resources;improved;Information Systems;Infrastructure;insight;Institution;institutional capacity;Leadership;Learning;Maps;medical schools;Methods;Mission;National Institute on Minority Health and Health Disparities;Needs Assessment;North Carolina;Outcome;peer;population health;Poverty;Productivity;Qualifying;Race;racial diversity;Reduce health disparities;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Rural;Schools;Science;social health determinants;Strategic Planning;Support System;supportive environment;Surveys;synergism;System;Teacher Professional Development;Time;Training;Translational Research;Underrepresented Populations;Underrepresented Students;Unemployment;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: RACING AHEAD (Research-focused Assessment of Capacity, Institutional Needs and Growth strategies to Advance Health Equity and Address Disparities)

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 XLN (M1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Patient Safety;Racial and Ethnic Minority Health Research;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Transition age adults (ages 18-25) with opioid use disorders are poorly served by the current treatment system for substance use disorders. This study will examine the variation in quality of treatment for opioid use disorders for this age cohort and examine multilevel factors—individual, community, treatment program—associated with higher quality care. The findings from this study will inform clinical decision making by patients and providers as well as public health responses to the rising tide of young adults seeking treatment for OUD.

PI_NAMEs: NEIGHBORS, CHARLES J (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: addiction;Address;Adherence;Adult;Adverse event;Age;age group;Belief;Biological;Black Populations;Black race;Brain;Caring;Characteristics;Clinical;clinical decision-making;cohort;Communities;community-level factor;critical developmental period;Data;Data Set;Development;Disparity;Drug Prescriptions;Early treatment;Ecology;effective therapy;efficacious treatment;ethnic difference;Ethnic Population;health disparity;Health Services;Individual;Informal Social Control;Institution;Intervention;Interview;Latinx;Latinx population;Leadership;Medicaid;medication administration;medication for opioid use disorder;meetings;Mental Health;Methods;Minority;Modeling;multidisciplinary;multiple data sources;Neurologic;New York;Nurse Practitioners;opioid use disorder;organizational structure;Outcome;outreach;Overdose;parent grant;parent project;parental monitoring;Parents;Patients;Performance;Pharmaceutical Preparations;Pharmacotherapy;Physician Assistants;Physicians;Policy Maker;Prevalence;Process;programs;Provider;psychologic;Public Health;Quality of Care;racial difference;racial population;recruit;Registries;Research;Research Personnel;response;Rewards;Role;social;Social Change;social expectations;stem;Structure;Substance Use Disorder;System;treatment program;treatment response;Variant;young adult;Youth

PROJECT_TITLE: Organizational factors associated with quality of care for opioid use disorders among transition-age adults in Medicaid - Revision  - Revision - 1 - Diversity Supplement

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: RELEVANCE Home visiting programs offer a potentially effective and sustainable framework for delivering interventions to improve cardiovascular health (CVH) among women and children. As part of the “Early Intervention to Promote Cardiovascular Health of Mothers and Children” (ENRICH) program, this project proposes to develop, implement, and evaluate a CVH intervention integrated into home visiting programs throughout Alabama, which has some of the highest cardiovascular disease mortality rates in the country. This study will examine the intervention’s health benefits for mothers and their children (aged 0-4 years) as well as factors associated with the implementation of the program.

PI_NAMEs: DUTTON, GARETH R (contact)

PROJECT_TERMS: Adherence;Adolescence;adverse pregnancy outcome;Affect;African American;aged;Alabama;Behavior Therapy;behavioral health intervention;black women;Blood Pressure;Body mass index;burden of illness;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Caring;Child;Childhood;Chronic;Clinical;clinical center;clinical practice;Collaborations;community engagement;Community Practice;contextual factors;Country;County;Data Collection;Death Rate;demographics;design;Deterioration;dietary;Dose;early childhood;Early Intervention;Education;effectiveness evaluation;Effectiveness of Interventions;effectiveness outcome;effectiveness/implementation trial;Eligibility Determination;emerging adult;Enrollment;ethnic minority;evidence base;experience;Family;follow-up;Gestational Age;Gestational Diabetes;gestational weight gain;Glucose;good diet;Health;Health behavior;Health Benefit;health care availability;health of the mother;health related quality of life;high risk;Home;Home environment;Home visitation;Household;Hypertension;implementation evaluation;implementation outcomes;improved;improved outcome;in utero;Income;Infrastructure;Interdisciplinary Study;Intervention;intervention refinement;Life;Lipids;Low income;Maternal and Child Health;maternal risk;Measures;Medical;member;mortality;Mothers;next generation;novel;Obesity;obesity prevention;offspring;Outcome;Perinatal;Phase;Physical activity;Pilot Projects;Positioning Attribute;Postpartum Period;Pre-Eclampsia;Pregnancy;Preparation;preservation;preventive intervention;primary outcome;Procedures;programs;Protocols documentation;psychosocial outcome;Public Policy;Race;racial minority;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Research Design;Research Personnel;Resources;Risk;Risk Factors;secondary outcome;sedentary;Services;Site;Sleep;Smoking;social health determinants;Standardization;sustainability framework;Time;tobacco exposure;Training;Vulnerable Populations;Woman;Women's Health;women's morbidity;Women's mortality;Work

PROJECT_TITLE: ENRICH ALABAMA: Improving cardiovascular health of women and children through a novel home visiting intervention


ORG_CITY: Newark

ORG_DEPT: PEDIATRICS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Narrative The NJ ACTS K12 Career Development Program, Doctors as Valued Learning Partners (DEVELOP), prepares early career faculty for independent careers in translational sciences. The program provides mentorship, personalized training, educational opportunities, salary, research, and travel support to prepare Scholars for an independent research career. Scholars will engage in research in translational science grounded in preclinical, clinical, epidemiologic, behavioral, or community-based research methods under the mentorship of teams of highly qualified, committed faculty from the four NJ ACTS partner institutions.

PI_NAMEs: CHAN, JOHN R.;HALM, ETHAN A (contact)

PROGRAM_OFFICER_NAME: GANNOT, GALLYA

PROJECT_TERMS: Academy;Awareness;Basic Science;career;career development;Clinical;Clinical Sciences;clinical translation;community setting;Development;Development Plans;didactic education;Disease;Doctor of Pharmacy;Doctor of Philosophy;Doctor's Degree;early-career faculty;Educational Curriculum;Ensure;Environment;Ethics;experience;Faculty;faculty mentor;Fostering;Future;Health;health care delivery;Health Sciences;Health system;improved;Individual;innovation;Institution;interest;Journals;K-Series Research Career Programs;knowledge base;Leadership;Learning;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Methodology;multidisciplinary;New Jersey;Outcome;pandemic disease;personalized approach;Process;Productivity;programs;Public Policy;Qualifying;recruit;Research;Research Personnel;Resources;response;Scientist;skills;Structure;Technology;tool;Training;Translating;Translational Research;translational scientist;Universities

PROJECT_TITLE: NJ ACTS: A Platform for Translational Science in New Jersey: CTSA K12 Program at Rutgers, Biomedical Health Sciences


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Equitable TRanslational science to Accelerate Impact of New innovations (E-TRAIN) T32 is proposed as a postdoctoral training program for the Northwestern University Clinical and Translational Sciences (NUCATS) Institute. This 2-year program expands domain expertise through mentored research and develops skills in cross-disciplinary team science to accelerate development, demonstration, and dissemination of new health innovations. Inclusive excellence, equitable and anti-racist study design, and trainee wellness will support human-centered design, dissemination, and implementation. Trainees will be prepared to contribute to the goal of the National Center for Advancing Translational Science of “bringing more treatments to all people more quickly” by reducing clinical and translational science (CTS) barriers.

PI_NAMEs: GOLLAN, JACQUELINE K;MCCOLLEY, SUSANNA A (contact)

PROGRAM_OFFICER_NAME: CONROY, JENNIE LYNN

PROJECT_TITLE: NUCATS T32


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Relevance Synaptic plasticity is integral to development and experience-dependent changes in the brain. While there have been attempts to link synaptic plasticity mechanisms discovered in reduced preparations to in-vivo function such as memory formation, important challenges and questions remain. We are now at the point of being able to address these important questions, but the challenge of integrating molecular mechanisms to behavior remains. Global collaboration between molecular and cellular biologists, technology developers and systems neuroscientists is critically important to connect mechanistic level knowledge of synaptic function to in-vivo behavior.

PI_NAMEs: SHEPHERD, JASON D (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TITLE: Investigating the mechanisms of Arc‐dependent synaptic plasticity

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE This proposal aims to test an intervention to improve cardiovascular health among high risk mothers and young children. Home visitation models meeting federal criteria of evidence of effectiveness will be leveraged to test the effectiveness of the intervention in a multicenter clinical trial.

PI_NAMEs: LEGRO, RICHARD S.;PAUL, IAN M (contact)

PROJECT_TERMS: 2 year old;3 year old;Address;Affect;American Heart Association;Appalachian Region;Area;Behavior;Behavior Therapy;Behavioral;Birth;Body mass index;cardiovascular health;caregiving;Caring;Categories;Cessation of life;Child;Child Health;Child Rearing;Childbirth;Childhood;cigarette smoking;Client;Cluster randomized trial;Collaborations;Communities;Community Health;community partners;comorbidity;Computerized Medical Record;Conceptions;County;data sharing;design;disparity reduction;Documentation;early childhood;Early Intervention;economic disparity;Educational Curriculum;Effectiveness;Effectiveness of Interventions;effectiveness testing;efficacious intervention;Enrollment;experience;Family;Family Nursing;food security;Goals;Growth;Habits;Health;Health Care Sector;health equity;health information technology;health of the mother;Health Personnel;Health Services Accessibility;Health system;Healthcare;healthy lifestyle;Heart Diseases;high risk;Home;Home environment;Home visitation;Household;hybrid type 1 trial;implementation context;Implementation readiness;improved;improved outcome;indexing;infancy;Infant;Infant Care;Informal Social Control;Interruption;Intervention;Intervention Studies;Knowledge;Lead;Life;Life Style;lifestyle intervention;Link;Manuals;Maternal and Child Health;maternal outcome;Measures;medically underserved;meetings;member;Metabolic syndrome;Minority Groups;Modeling;mortality;Mothers;Multi-Institutional Clinical Trial;Multicenter Trials;multidisciplinary;National Heart, Lung, and Blood Institute;Nurses;Nutritional;Nutritionist;Obesity;obesity prevention;obstetric care;operation;Outcome;Participant;Patient Recruitments;Phase;pilot test;Positioning Attribute;Postpartum Period;Poverty;Pregnancy;Pregnant Women;prenatal;Primary Care;primary outcome;Primary Prevention;programs;Protocols documentation;psychosocial;Randomized;rapid infant weight gain;Research;Research Design;Risk;Risk Factors;role model;rural setting;Schedule;Self Efficacy;Site;skills;Sleep;social cognitive theory;social health determinants;Testing;therapy design;tobacco exposure;Tobacco use;Training;Treatment Efficacy;tv watching;underserved area;urban setting;Visit;Vulnerable Populations;Weight;Woman;women's outcomes;Work

PROJECT_TITLE: Early Intervention to Promote Cardiovascular Health of Mothers and Children in Northern Appalachia


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Infertility;Maternal Health;Regenerative Medicine;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Dilation & curettage (D&C) is one of the most common surgical procedures performed on women throughout the World, with resulting intrauterine fibrosis developing in ~40% of women who undergo D&C in the postpartum (6wk period after birth), but is very rare after D&C in nonpregnant women (<1%). While stem/progenitor cells and macrophage immune cells are crucial for endometrial repair, the role of these cells and underlying molecular mechanisms in this susceptibility of the endometrium to fibrosis and abnormal repair are unknown. This work will have an important impact on the reproductive field by revealing mechanisms underlying abnormal uterine repair, and on the medical field at large by providing insights into the body’s physiological anti-fibrotic wound healing mechanisms, leading to a deeper understanding of the pathogenesis of fatal idiopathic fibrotic diseases in other organs.

PI_NAMEs: TAL, RESHEF  (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Adhesions;Biology;Birth;Cells;Cicatrix;Coculture Techniques;Dangerousness;Dilatation and Curettage;Disease;Endometrial;Endometrium;Fibroblasts;Fibrosis;Human;Immune;In Vitro;Infertility;Injury;innovation;insight;Knowledge;Macrophage;Macrophage Activation;Medical;Mesenchymal Stem Cells;Modeling;Molecular;Mus;novel;Operative Surgical Procedures;Organ;Pathogenesis;Patients;Phenotype;Physiological;Play;Population;Postpartum Period;Predisposition;Pregnancy Complications;Pregnancy loss;Premature Birth;Recurrence;repaired;reproductive;response;response to injury;Role;stem cells;Uterus;Woman;Work;wound healing

PROJECT_TITLE: THE ROLE OF MESENCHYMAL PROGENITOR CELLS IN ABNORMAL UTERINE REPAIR

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Dental, Oral, and Craniofacial Disease

ORG_CITY: NASHVILLE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: Project Narrative The Meharry STRONG Program is designed to systematically assess current research capacity and strengths, identify critical gaps and barriers, and develop evidence-based action plans to address top priorities. The outcomes of our assessment will be the identification of capacity-building interventions that we can undertake to strengthen our research framework and capacity.

PI_NAMEs: CHEAIRS, TANEISHA GILLYARD;GANGULA, PANDU R;LINDSEY, MERRY L. (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: Active Listening;Address;Area;Assessment tool;Big Data;Biomedical Research;biomedical scientist;Calibration;Cardiovascular Diseases;career;Communicable Diseases;Communities;Data;Data Analyses;Data Collection;database query;Dedications;design;Development;Disease Outcome;diverse data;Doctor of Philosophy;empowerment;Ensure;Environment;Evaluation;evidence base;Faculty;Feedback;Fostering;Funding;Goals;Grant;Growth;health data;Health equity research;Health Professional;Health Sciences;health training;Historically Black Colleges and Universities;improved;inferential statistics;Infrastructure;insight;Institution;interest;Intervention;Leadership;Malignant Neoplasms;medical schools;Needs Assessment;Outcome;Personal Satisfaction;Population Heterogeneity;Privatization;Probability;Process;programs;Public Health;Reduce health disparities;Research;Research Infrastructure;Resources;Series;Source;Strategic Planning;Students;success;Surveys;tool;Training;Uncertainty;Voice

PROJECT_TITLE: STrengthening Research OpportuNities for Growth at Meharry Medical College (Meharry-STRONG)


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: RENO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: PROJECT NARRITIVE Preterm labor leads to preterm delivery of an underdeveloped fetus in 50% of cases and there are no FDA- approved medications available to prevent preterm delivery. The research planned in this application will employ tissues and cells from pregnant women. Mariani Ramirez is a diversity applicant whom we will mentor to examine the role of endogenous nitric oxide, which relaxes the muscle of the term, but not preterm human uterus, in regulating the formation of gap junctions that couple the tissue electrically and coordinate labor contractions.

PI_NAMEs: BUXTON, IAIN L (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: African American Women;Biomedical Research;Blood flow;C-terminal;Caucasians;Cells;Cessation of life;Connexin 43;Development;disability;Doctor of Philosophy;extreme prematurity;FDA approved;Fetus;Gap Junctions;Hour;Human;Label;Mechanics;Medical;Mentors;Muscle Cells;Muscle relaxation phase;Myometrial;myometrium;Nitric Oxide;Nitrosation;Pharmaceutical Preparations;Phosphorylation;Post-Translational Protein Processing;Pregnancy;Pregnant Women;Premature Birth;Premature Infant;Premature Labor;prevent;Relaxation;Research;Role;Stretching;Therapeutic;Time;Tissues;Tocolysis;Tocolytic Agents;translational approach;Uterus;Vascular Endothelial Cell;women of color

PROJECT_TITLE: Post-translational Modification of Cx43 Regulates Myometrial Quiescence

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Emergency Care;Health Services;Neurodegenerative;Neurosciences

ORG_DEPT: EMERGENCY MEDICINE

PHR: PROJECT NARRATIVE: The Geriatric Emergency care Applied Research network 2.0 – Advancing Dementia Care brings together leaders who have transformed the emergency care of older adults and partners them with Alzheimer's disease and related dementia (ADRD) experts to optimize care and improve the health of older persons with dementia. It will leverage existing networks and organizations to prioritize research gaps and support pilot grant opportunities for future larger-scale, full proposals.

PI_NAMEs: HWANG, ULA Y (contact);SHAH, MANISH N

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acceleration;Accident and Emergency department;Accreditation;Address;Admission activity;advanced dementia;Advisory Committees;Alzheimer's Disease;Alzheimer's disease related dementia;Applied Research;Award;Caregivers;Caring;Collaborations;Communication;Consensus;Consultations;Data;data warehouse;Decision Making;Delirium;Dementia;dementia care;Detection;Development;Dissemination and Implementation;Education;Elderly;Emergency Care;Emergency Department patient;Emergency department visit;Emergency Medicine;Environment;evidence base;experience;Fostering;Foundations;Funding;Funding Opportunities;Future;Geriatrics;Goals;Grant;Growth;Guidelines;Health;Hospitals;implementation science;improved;Informatics;Infrastructure;innovation;Knowledge;large scale data;Lead;learning network;medical specialties;meetings;Multicenter Studies;Network Infrastructure;older adult;Older Population;operation;Persons;Phase;Pilot Projects;Process;Productivity;programs;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Priority;Research Support;Resources;Risk Factors;Science;skills;Testing;United States National Institutes of Health;Update


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE With 10 million residents, Los Angeles County is the most populous in the US; three-quarters of residents identify as ethnic minorities and more than one-third were born outside the US; and nearly 1.5 million people are below the poverty line. Rates of premature death and disability related to heart disease, diabetes, stroke and violence exceed national averages; the disease burden is magnified by language barriers, cultural beliefs, poverty and disparities in access to care. The goal of the CTSI is to bring biomedical innovations to bear on the greatest health needs of Los Angeles—one of the nation's most ethnically, socially and economically diverse counties.

PI_NAMEs: BROWN, ARLEEN F.;DUBINETT, STEVEN M. (contact);NAEIM, ARASH

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: Acceleration;access disparities;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Behavior;Belief;Boston;burden of illness;California;career;Career Choice;Caregivers;Caring;Cessation of life;Clinical;Clinical Psychology;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communication;Communication Methods;Communities;community based participatory research;Community Health Education;community organizations;Community Outreach;community partners;community-centered;County;cultural competence;Dementia;design;Diabetes Mellitus;Diagnosis;disability;diversity and inclusion;Doctor's Degree;Education;Education and Outreach;Environment;Equity;equity, diversity, and inclusion;ethnic minority;Ethnic Origin;Ethnic Population;Event;experience;Faculty;Family;Fellowship;First Generation College Students;Goals;graduate school;Health;health care availability;health care disparity;health disparity;health literacy;Health Occupations;Health Services Accessibility;Healthcare Systems;healthy aging;Heart Diseases;Hispanic Populations;Home;improved;Informatics;Informed Consent;Infrastructure;innovation;Institution;interest;Language;Latino Population;Latinx;Limited English Proficiency;Linguistics;Lived experience;Los Angeles;Massachusetts;Medical;Medical center;medical schools;Medicine;Methodology;Methods;Mission;Modeling;multidisciplinary;National Center for Advancing Translational Sciences;Neurology;Neuropsychology;Neurosciences Research;oral communication;Outcome;outreach program;parent grant;Participant;Patients;Persons;population health;Positioning Attribute;Postdoctoral Fellow;Poverty;premature;Primary Care;Process;programs;Psychiatry;Publications;Puerto Rico;racial minority population;Research;Research Infrastructure;Research Personnel;Science;Scientist;simulation;Site;skills;social;Spanish;Special Population;Speed;Stroke;Tennessee;Testing;Time;Training;Training and Education;Training Programs;translational impact;translational pipeline;Translational Research;Translations;trial design;Trust;trustworthiness;United States;Universities;Violence;volunteer;willingness;Woman;Writing

PROJECT_TITLE: UCLA Clinical and Translational Science Institute


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Mental Health;Neurosciences;Stroke

ORG_CITY: Aurora

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE - FROM PARENT AWARD Cognitive impairment following stroke is emerging as one of the leading causes of disability in the country. Despite large research efforts, there are currently no approved pharmacotherapies for improving functional outcomes following stroke. This proposal aims to uncover molecular mechanisms underlying stroke-induced synaptic and cognitive deficits to identify potential molecular targets for pharmacologic intervention.

PI_NAMEs: BURCH, AMELIA  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;Address;Adenosine Diphosphate Ribose;Affect;Animal Model;Astrocytes;Attention;Behavioral Assay;Biological Assay;Brain;Brain region;calmodulin-dependent protein kinase II;Cations;Cause of Death;Cell model;cell type;Cells;Central Nervous System;Cerebral Ischemia;Chronic;Clinical Trials;Cognitive;Cognitive deficits;cognitive disability;cognitive load;cognitive process;Country;Data;Dementia;disability;Electrophysiology (science);Endothelium;Ensure;executive function;Exhibits;experience;Family;functional improvement;Health;Healthcare Systems;Hippocampus;Human;Image;Immunofluorescence Immunologic;Impaired cognition;Impairment;improved;In Vitro;in vivo;Infarction;inhibitor;Injections;Intervention;Ion Channel;Ischemia;ischemic injury;Ischemic Stroke;Knock-out;Knockout Mice;Language;Learning;Ligands;Long-Term Potentiation;Measures;Memory;Memory impairment;Microglia;middle cerebral artery;Middle Cerebral Artery Occlusion;mild cognitive impairment;Modeling;Molecular;Molecular Target;molecular targeted therapies;mortality risk;mouse model;Mus;neural network;Neural Pathways;neurobehavioral;Neurologic;Neurons;neuroprotection;neurorestoration;novel;novel therapeutic intervention;Oxidative Stress;parent project;Pathology;Pathway interactions;patient population;Patients;pharmacologic;Pharmacotherapy;Phenocopy;post intervention;post stroke;preservation;Procedures;receptor;Recovery of Function;Reperfusion Therapy;Research;restoration;Role;sex;Short-Term Memory;Signal Transduction;Slice;Source;Stroke;Survivors;Symptoms;Synapses;synaptic function;Synaptic plasticity;Therapeutic Intervention;Thrombolytic Therapy;treatment strategy;United States;Up-Regulation

PROJECT_TITLE: CD38 activation of TRPM2 in hippocampal neurons contributes to stroke-induced cognitive dysfunction


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: Self-destructive behaviors such as self-injury, disordered eating, and substance use are common among Veterans with posttraumatic stress disorder (PTSD) and other trauma or stressor-related disorders and are linked to profound distress and impairment. The proposed study would use advanced computational methods to model [the cognitive, emotional, physiological, and behavioral processes] that maintain suicidal ideation and other self-destructive behaviors at both the group and individual levels in gender-balanced samples of Veterans. Knowledge generated by this research could be used to improve existing trauma-focused treatments and develop personalized, real-time assessment and intervention tools for Veterans who engage in self- destructive behaviors in the context of traumatic stress.

PI_NAMEs: ZELKOWITZ, RACHEL L (contact)

PROJECT_TERMS: adaptive intervention;Address;Affect;Affective;Alcohols;Area;Assessment tool;Award;Behavior;Behavioral;Behavioral Symptoms;Binge Eating;Boston;career;career development;Characteristics;Clinical;Clinical Investigator;Clinical Psychology;clinically significant;Cognition;Cognitive;comorbidity;Complex;Computing Methodologies;Data Analyses;Data Collection;density;depressive symptoms;Detection;Development;Disease;Disparate;Distal;Distress;Drug usage;Eating Disorders;Ecological momentary assessment;Emotional;Environment;experience;Feeling suicidal;follow-up;food restriction;Future;Gender;Goals;Health Sciences;Healthcare Systems;Impairment;improved;Individual;Injury;Intervention;Knowledge;Link;Maps;Mental disorders;Mentorship;Methodology;Methods;Modeling;Monitor;Moods;network models;non-suicidal self injury;Outcome;Pathway Analysis;personalized care;Physiological;post 9/11;Post-Traumatic Stress Disorders;Postdoctoral Fellow;Principal Investigator;Process;Protocols documentation;psychologic;purge;real time model;recruit;Regression Analysis;Reporting;Research;Research Personnel;Research Priority;response;Risk;Risk Marker;Sampling;Secondary to;Self Destructive Behavior;Self Direction;Self-Injurious Behavior;Services;skill acquisition;stressor;substance use;suicidal;suicidal behavior;suicidal morbidity;Suicide;Suicide attempt;Suicide prevention;Supervision;Symptoms;System;Techniques;Testing;Time;tool;Training;Trauma;trauma exposure;traumatic stress;Treatment outcome;Universities;Validation;Veterans;Violence;Woman;women versus men;Women's Health

PROJECT_TITLE: Psychological Drivers of Self-Destructive Behaviors in PTSD


ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

PHR: Alcohol and prescription opioid use disorders and comorbid major depressive disorder (MDD) are costly and prevalent in Veterans and associated with poor clinical outcomes, including an elevated risk of mortality. Despite the urgent need to improve treatment and reduce the burden of these co-occurring disorders on Veterans, the shared genetic vulnerability underlying them is poorly understood. Prior studies are limited by inadequate power to detect small effects, a lack of population diversity, and inadequate associated phenotypic information. This CDA-2 application addresses these limitations by using data from the Million Veteran Program, a longitudinal, electronic health record-based biobank, to investigate the genetic architecture of alcohol and prescription opioid use and comorbid MDD. Findings from this CDA-2 will increase our understanding of the etiology, genetic architecture, associated phenotypes, and causal pathways between these comorbidities and inform precision medicine approaches to these disorders in Veterans.

PI_NAMEs: HARTWELL, EMILY  (contact)

PROJECT_TERMS: Address;African ancestry;alcohol comorbidity;Alcohol consumption;alcohol use disorder;Alcohols;biobank;Bioinformatics;Biological;career;Caring;Categories;Chronic;chronic pain;Clinical;comorbid depression;comorbidity;comparison group;Complex;Consumption;Control Groups;cost;Data;Death Rate;depressive symptoms;Development;Diagnosis;Disease;Disease Progression;disorder risk;Drops;dual diagnosis;Electronic Health Record;Etiology;European ancestry;Foundations;Genes;Genetic;genetic architecture;genetic association;genetic epidemiology;Genetic Heterogeneity;Genetic Predisposition to Disease;Genetic Research;genetic variant;genome wide association study;Genotype;Goals;Health;Heritability;Heterogeneity;ICD-9;Impairment;improved;Individual;Investigation;Major Depressive Disorder;Measures;Medical;Medicine;Mendelian randomization;Mental Depression;mortality;mortality risk;novel;opioid use;opioid use disorder;Outcome;Pain;Pathway interactions;Patient Self-Report;Patients;personalized medicine;Pharmaceutical Preparations;phenome;Phenotype;phenotypic data;pleiotropism;polygenic risk score;Population Heterogeneity;Post-Traumatic Stress Disorders;precision medicine;prescription opioid;Prevention;Prevention strategy;Primary Care;programs;psychiatric comorbidity;Psychiatric Diagnosis;psychogenetics;Quality of life;Questionnaires;Recording of previous events;Relapse;Research;Risk;Sampling;Self Medication;Severities;Specific qualifier value;Statistical Methods;statistics;substance use;Substance Use Disorder;substance use treatment;suicidal risk;symptomatology;Symptoms;Testing;Training;trait;Translational Research;Treatment outcome;treatment strategy;Variant;Veterans

PROJECT_TITLE: Genetic architecture of substance use disorders and major depression


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Rare cancers comprise over 25% of tumors in U.S. adults, but due to low incidence and geographically dispersed patient populations, they are challenging to study, leading to significant unmet clinical needs. This proposal will form a Research Center that will directly engage patients with two such rare cancers – osteosarcoma and leiomyosarcoma – as partners in research in order to generate a large shared database of clinical, genomic, molecular, and patient reported data. We hope that this work can accelerate discoveries that drive novel treatment strategies, new clinical trials, and new standards of care, and also serve as a model for patient- partnered research in other cancer types and patient communities.

PI_NAMEs: GEORGE, SUZANNE ;JANEWAY, KATHERINE A (contact);MACK, JENNIFER W;VAN ALLEN, ELIEZER M

PROGRAM_OFFICER_NAME: GILLANDERS, ELIZABETH

PROJECT_TERMS: Acceleration;Address;Adult;Age;anti-cancer research;Behavioral Research;Behavioral Sciences;Biology;Blood;bone;Bone neoplasms;Cancer Patient;cancer type;Caring;cell free DNA;Child;Childhood;Clinical;Clinical Data;clinical database;Clinical Research;Clinical Trials;Communities;Computational Biology;Computer Analysis;Consent;Country;Dana-Farber Cancer Institute;Data;data de-identification;Data Reporting;Data Science;Databases;Development;Diagnostic Procedure;Disparate;empowerment;exome;experience;Failure;Genome;genomic data;Genomics;Geography;Germ Lines;Goals;improved;Incidence;Institution;Intervention Studies;Leadership;leiomyosarcoma;literacy;Malignant Neoplasms;Medical Records;member;Mesenchymal;Minority;Modeling;Molecular;Morbidity - disease rate;novel;Observational Study;Osteosarcoma;Participant;patient engagement;patient population;Patient Recruitments;Patients;Prevention strategy;primary bone cancer;Primary Neoplasm;prognostic indicator;public database;rare cancer;Research;Risk Factors;Rural;Saliva;Sampling;Sarcoma;shared database;Smooth Muscle;social media;Specimen;Survival Rate;targeted treatment;therapeutic biomarker;therapy resistant;Time;Tissue Sample;transcriptome;Translational Research;treatment response;treatment strategy;tumor;tumor DNA;Tumor Tissue;web site;whole genome;Work

PROJECT_TITLE: Count Me In: Partnering with patients to define the clinical and genomic landscape of rare aggressive sarcomas in children and adults


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

PI_NAMEs: WAGLE, NIKHIL  (contact)

PROJECT_TERMS: Acceleration;Accountability;Administrator;Adult;Advisory Committees;Advocacy;Age;anti-cancer research;Behavioral Research;Behavioral Sciences;Benchmarking;Blood;bone;Cancer Biology;cancer genomics;Caring;Child;Childhood;Clinical;Clinical Data;clinical database;Clinical Research;Clinical Trials;Communication;Communities;Computational Biology;Computational Science;Computer Analysis;Consent;Cross Presentation;Dana-Farber Cancer Institute;Data;data de-identification;Data Reporting;Data Science;Databases;Development;Diagnostic Procedure;Electronics;Elements;Ensure;Expenditure;experience;Failure;Genome;genomic data;Genomics;Germ Lines;Goals;Immunology;improved;Leadership;leiomyosarcoma;literacy;Malignant Neoplasms;Medical Records;meetings;member;Minority;Molecular;Monitor;Morbidity - disease rate;novel;Osteosarcoma;Participant;Pathology;patient engagement;Patient Recruitments;Patients;Pediatric Oncology;Persons;Population Sciences;precision medicine;Prevention strategy;programs;rare cancer;Reporting;Research;Research Personnel;Research Project Grants;Rural;Saliva;Sarcoma;Series;shared database;Smooth Muscle;Specimen;Survival Rate;targeted treatment;Technology;Time;Tissue Sample;tool;Translational Research;treatment strategy;tumor;tumor DNA;Tumor Tissue;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: PAINTER, CORRIE ANN (contact)

PROJECT_TERMS: Acceleration;Adult;Age;anti-cancer research;Behavioral Research;Behavioral Sciences;Blood;bone;Caregivers;Caring;Child;Childhood;Clinical;Clinical Data;clinical database;Clinical Research;Clinical Trials;Communication;Communities;Computational Biology;Computer Analysis;Consent;Dana-Farber Cancer Institute;Data;Data Aggregation;data de-identification;Data Reporting;Data Science;Data Set;Databases;design;Development;Diagnostic Procedure;Disease;empowerment;Enrollment;Ethnic Origin;experience;Failure;Gender;Genome;genome sequencing;genomic data;genomic profiles;Genomics;Geographic Locations;Geography;Germ Lines;Goals;improved;Individual;Infrastructure;Intervention;Joints;Knowledge;Leadership;leiomyosarcoma;literacy;loved ones;Medical Records;member;metastatic process;Minority;Molecular;Morbidity - disease rate;Mutation;novel;operation;Osteosarcoma;outreach;Participant;patient engagement;patient population;Patient Recruitments;Patients;pediatric patients;Prevention strategy;Process;Race;rare cancer;repository;Research;Research Design;Research Personnel;research study;Resistance;Rural;Saliva;Sarcoma;shared database;Smooth Muscle;Specimen;standard of care;success;Survival Rate;targeted treatment;Time;Tissue Sample;Translational Research;treatment strategy;tumor;tumor DNA;Tumor Tissue;understudied cancer;United States;web site

PROJECT_TITLE: Participant Engagement Unit


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Genetics;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: GABRIEL, STACEY  (contact)

PROJECT_TERMS: Acceleration;Adult;Age;analytical tool;anti-cancer research;Back;Behavioral Research;Behavioral Sciences;Biological Assay;Blood;bone;Cancer Center;cancer genome;cancer genomics;Caring;cell free DNA;Child;Childhood;childhood sarcoma;Clinical;Clinical Data;clinical database;Clinical Research;Clinical Trials;clinically relevant;Collaborations;Communities;Computational Biology;Computer Analysis;computerized data processing;Consent;Dana-Farber Cancer Institute;Data;Data Analytics;data de-identification;Data Files;Data Reporting;Data Science;Databases;Development;Diagnostic Procedure;exome sequencing;experience;Failure;Family;Funding;Genome;genome sequencing;genomic data;genomic platform;genomic profiling;Genomics;Germ Lines;Goals;improved;Infrastructure;Leadership;leiomyosarcoma;literacy;Malignant Neoplasms;Medical Records;member;Minority;Molecular;Morbidity - disease rate;National Human Genome Research Institute;novel;Osteosarcoma;Participant;patient engagement;Patient Participation;Patient Recruitments;Patients;Prevention strategy;Process;programs;rare cancer;Reporting;Research;RNA;Rural;Saliva;Sampling;Sarcoma;shared database;Smooth Muscle;Specimen;Survival Rate;targeted treatment;The Cancer Genome Atlas;Time;Tissue Sample;tool;transcriptome;Translational Research;treatment strategy;tumor;tumor DNA;Tumor Tissue;web site;whole genome

PROJECT_TITLE: Genome Characterization Unit


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Social Determinants of Health

PI_NAMEs: MACK, JENNIFER W (contact)

PROJECT_TERMS: Acceleration;Address;Adolescent;Adolescent and Young Adult;Adult;Age;anti-cancer research;Area;Behavioral Research;Behavioral Sciences;Blood;Blood specimen;bone;cancer clinical trial;Caring;Child;Childhood;Clinical;Clinical Data;clinical database;Clinical Research;Clinical Trials;Communication;Communities;Computational Biology;Computer Analysis;Consent;Country;Dana-Farber Cancer Institute;Data;data de-identification;Data Reporting;Data Science;Databases;Decentralization;Development;Diagnostic Procedure;Disease;Economics;efficacy trial;Electronics;Enrollment;Ensure;ethnic minority;Ethnic Origin;experience;Failure;Feedback;Future;Genome;genomic data;genomic profiling;Genomics;Germ Lines;Goals;Hemangiosarcoma;improved;Intervention;Intervention Trial;Knowledge;Leadership;leiomyosarcoma;literacy;Literature;Malignant Neoplasms;Medical Records;member;Metastatic breast cancer;Metastatic Prostate Cancer;Minority;Molecular;Morbidity - disease rate;novel;Osteosarcoma;Outcome;outreach;Participant;participant enrollment;patient engagement;Patient Recruitments;Patient-Focused Outcomes;Patients;Phase;Population;Population Heterogeneity;Prevention strategy;Process;Protocols documentation;Race;racial minority;rare cancer;Rare Diseases;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;Rural;rural area;rural dwellers;Saliva;saliva sample;Sarcoma;shared database;Site;Smooth Muscle;social;Specimen;success;Survival Rate;targeted treatment;Testing;Time;Tissue Sample;Translating;Translational Research;Translations;treatment strategy;tumor;tumor DNA;Tumor Tissue;Underrepresented Populations;understudied cancer;United States;web site;Work;young adult

PROJECT_TITLE: Engagement Optimization Unit


ADMINISTERING_IC: EB

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Data Science;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative:  The substrate specificity of E3 ligases determines which proteins in a cell are targeted for degradation. Changes in substrate specificity can lead to disease (in the case of mutations) or enable potential treatments (in the case of pharmacological agents such as molecular glues). Here we propose novel computational approaches to identify endogenous substrates and to identify molecular glues that will target specific disease- causing proteins.

PI_NAMEs: MISCHLEY, VICTORIA  (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: ADAR1;Address;Autoimmune Diseases;Benchmarking;Binding;Biological;Biological Assay;Biology;Catalogs;Cells;Complex;computerized tools;Computing Methodologies;Data;Descriptor;design;Development;Disease;drug discovery;Equilibrium;Future;Glues;Goals;Human;human disease;immune checkpoint blockade;Immunotherapy;improved;insight;interest;Intervention;Laboratories;Ligase;Machine Learning;machine learning classifier;machine learning method;Malignant Neoplasms;Measures;Mediating;Methods;Modality;model building;Modeling;Molecular;multicatalytic endopeptidase complex;Mutation;Nature;Network-based;neural network;novel;pharmacologic;Polyubiquitin;prevent;protein degradation;protein protein interaction;protein structure prediction;Proteins;Proteome;rational design;Research Personnel;Resistance;response;small molecule;small molecule libraries;Specificity;structural biology;Structure;Substrate Interaction;Substrate Specificity;Testing;Time;Training;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;yeast two hybrid system

PROJECT_TITLE: Developing computational methods to identify of endogenous substrates of E3 ubiquitin ligases and molecular glue degraders


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Physical Activity

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Cognitive impairment begins early in Parkinson’s disease (PD) and progresses to dementia in a majority of patients, impairing quality of life and contributing to growing health-related costs. The proposed study is designed to study exercise and a novel aging-regulator, klotho, that may mediate-exercise induced benefits on cognition. This research has the potential to fill a major gap in identifying novel therapeutic strategies to counter cognitive decline in PD.

PI_NAMEs: LUTHRA, NIJEE  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acceleration;Adherence;Adult;Age;age effect;Aging;Alleles;alpha synuclein;Amyloid beta-Protein;anti aging;Attenuated;Awareness;Biological Markers;biomarker identification;Biostatistical Methods;Blood;Brain;brain volume;career;career development;Career Mobility;Clinical;Clinical Investigator;Clinical Trials;Cognition;Cognitive;cognitive ability;cognitive enhancement;cognitive function;cognitive impairment in Parkinson's;cognitive testing;cohort;Conduct Clinical Trials;Control Groups;cost;Critiques;data harmonization;Databases;Dementia;Denervation;design;Deterioration;Development;Disease;effective therapy;executive function;Exercise;exercise intervention;experience;genetic variant;Goals;Growth;Health;healthy aging;Home;Hormones;Impaired cognition;Impairment;improved;innovation;klotho protein;Letters;Life;Light;Link;Longevity;longitudinal analysis;Measures;Mediating;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;model organism;mouse model;Movement Disorders;multimodality;Nerve Degeneration;neural;neurofilament;Neurologist;novel;novel therapeutic intervention;novel therapeutics;Outcome;overexpression;pandemic disease;Parkinson Disease;Participant;Pathogenicity;Pathology;Pathway interactions;Patient Outcomes Assessments;Patients;Persons;Phenotype;Physical Exercise;Physical Performance;Pilot Projects;Population;progression marker;Proteins;Quality of life;Randomized;Randomized, Controlled Trials;Research;research and development;Research Personnel;Research Proposals;resilience;resistance exercise;response;Role;Serum;Signal Transduction;single photon emission computed tomography;Statistical Methods;Synaptic plasticity;tau Proteins;Testing;Training;Training Programs;treatment strategy;β-amyloid burden

PROJECT_TITLE: Enhancing Cognitive Resilience In Parkinson's Disease: Role Of Antiaging Protein Klotho

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This project will evaluate disparities in domestic mold exposure and asthma morbidity both before and after a large-scale intervention in New York City public housing to reduce mold, by determining their distributions across climatic, neighborhood, building, and individual characteristics. Such analyses directly support the NIEHS’s commitment to uncovering where exposure burdens combine with social determinants to impact health in an era of climate change. Our findings will inform more equitable mold interventions and housing policies.

PI_NAMEs: FLORES, NINA  (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Address;Adult;Affect;Age;Air;American;Asthma;asthma exacerbation;Atmosphere;authority;Black race;burden of illness;Censuses;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;Child;Chronic;Climate;climate change;Color;Communities;Construction Materials;Coronavirus;cost;Data;Data Collection;Development;Diagnosis;Disparate;Disparity;Disparity population;Economic Burden;Education;Emergency department visit;environmental justice;Equity;Ethnic Origin;Evaluation;Event;experience;Exposure to;extreme weather;Future;Growth;Health;Health Benefit;health data;Home;Household;Housing;Hurricane;improved;Incentives;Income;Individual;Insurance;Intervention;Knowledge;Legal;Link;Low income;lower income families;Molds;Morbidity - disease rate;mortality;National Institute of Environmental Health Sciences;Natural experiment;Neighborhoods;New York City;North America;parent grant;Parents;Policies;Prevalence;programs;Public Housing;Race;remediation;repaired;Reporting;Reproduction spores;Research;respiratory;response;Schools;Services;sex;social;social determinants;sociodemographics;socioeconomics;Subgroup;Symptoms;System;Temperature;Testing;Time Series Analysis;tool;Toxin;Training;underserved community;Underserved Population;United States;United States National Aeronautics and Space Administration;ventilation;Visit;Water;Weather;Work

PROJECT_TITLE: An equity-focused evaluation of a system-wide intervention to reduce mold in NYC public housing and its impact on asthma burden

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-E(20)L]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Lung;Networking and Information Technology R&D (NITRD);Physical Activity;Physical Rehabilitation;Pulmonary Hypertension;Rare Diseases;Rehabilitation;Telehealth

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE Increasing physical activity improves quality of life and functional capacity in patients with pulmonary arterial hypertension (PAH), a rare disease with a median survival of seven years. We recently demonstrated in a randomized pilot trial the feasibility of increasing step counts in patients with PAH using a text-based mobile health intervention. Accordingly, we now propose a larger, longer-term study to test whether increasing step counts through a mobile health intervention will improve quality of life in patients with PAH.

PI_NAMEs: BRITTAIN, EVAN L (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Activities of Daily Living;Adipose tissue;Adverse event;Age;Agreement;arm;Behavioral;Cardiopulmonary rehabilitation;Cellular Phone;Cessation of life;Clinical;cohort;Collection;cost;Data;Data Collection;data exchange;Databases;Devices;Dropout;Effectiveness;Enrollment;Event;Exercise;exercise capacity;experience;feasibility trial;fitbit;Funding;Goals;health related quality of life;Home;home test;Hospitalization;Impairment;improved;Individual;innovation;Inpatients;Institutional Review Boards;Insurance;Intervention;intervention effect;Link;Measures;mhealth interventions;Monitor;novel;Outcome;Participant;participant enrollment;Patient Outcomes Assessments;Patients;Pharmaceutical Preparations;Physical activity;Physical Fitness;pilot trial;Population;primary endpoint;Process;Psychology;Publishing;pulmonary arterial hypertension;Pulmonary Hypertension;Quality of life;Quality of Life Assessment;Questionnaires;Randomized;randomized trial;Rare Diseases;Registries;Rehabilitation therapy;Reproducibility;Right Ventricular Function;Risk;Safety;secondary endpoint;sex;Supervision;Testing;Text;Text Messaging;text messaging intervention;Theory of Change;Time;treatment arm;treatment as usual;United States;United States National Institutes of Health;Visceral;Walking

PROJECT_TITLE: The MObile Health InterVEntion in Pulmonary Arterial Hypertension (MOVE PAH) Study

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(MA)]


ADMINISTERING_IC: FD

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: DANBURY

ORG_NAME: SONATA SCIENTIFIC, LLC

PHR: Narrative Supply chains for more than 50% of medical devices are threatened by current and new ethylene oxide (EtO) regulations because of the limitations of current EtO control technologies. The proposed research will demonstrate an EtO abatement technology to minimize fugitive EtO emissions from sterilization facilities and warehouses beyond what is achievable with current approaches. The proposed technology addresses a void in current abatement strategies, creating the opportunity to dramatically reduce fugitive EtO emissions, ensure an uninterrupted supply chain of medical devices, and protect workers and communities from harmful EtO exposure.

PI_NAMEs: PETRUSKA, MELISSA A (contact)

PROGRAM_OFFICER_NAME: WILKICKI, KELLY

PROJECT_TITLE: Reduced EtO emissions to safeguard biomedical supply chains


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY

PHR: Narrative Addressing health disparities, especially in the face of COVID-19, requires an integrated multisector equity-focused, community-based approach. Our proposal examines the impact of Harlem Strong Community Mental Health and Economic Empowerment Collaborative, a community-wide multisectoral coalition in which a health insurer works with a network of community-based organizations, medical providers, and behavioral health provider to engage in a network- wide implementation planning process to: (1) problem solve financing, access, and quality of care barriers, (2) support capacity building for mental health task-sharing for community health workers, (3) facilitate coordination and collaboration across mental health / behavioral health, primary care, and a range of social services, including case management, housing supports, employment and financial education, and other community resources to improve linkages to services, and (4) identify a set of common mental health, social risk, and health metrics and strategies to integrate these metrics into data systems across the network for continuous quality improvement of the system. The long-term goal of our study is to develop sustainable model for task-sharing mental health care that will be embedded in a coordinated comprehensive network of services, including primary care, behavioral/mental health, social services, and other community resources.

PI_NAMEs: NGO, VICTORIA KHANH (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: Address;Adoption;Affect;American;Awareness;barrier to care;Behavioral;behavioral health;Black race;Businesses;care coordination;care providers;care systems;Caring;Case Management;Cessation of life;collaborative care;Communities;community based care;community engaged approach;community engagement;Community Financing;Community Health Aides;community intervention;Community Networks;community organizations;community partners;community planning;community setting;Competence;Complex;Coordination and Collaboration;cost effectiveness;Cost Savings;COVID-19;crowdsourcing;Development;Disparity;distrust;Economics;Education;Effectiveness;effectiveness testing;effectiveness/implementation design;Emotional;Employment;empowerment;Ensure;Equity;ethnic minority;Evaluation;evidence base;Evidence based intervention;Family;federal poverty level;Fireflies;Fortification;Goals;graduate school;hackathon;Health;health disparity;health knowledge;Health Personnel;Health Policy;Health system;high risk;Household;Housing;Human;Hybrids;implementation barriers;implementation evaluation;implementation outcomes;implementation strategy;implementation tool;implementation/effectiveness;improved;Inequity;infection rate;informant;Information Systems;innovation;insight;Institutional Racism;Institutionalization;Insurance Carriers;Interview;Job loss;Latino;learning community;Linguistics;Low income;Managed Care;Medical;Mental Health;Mental Health Services;Methods;Modeling;neighborhood safety;Neighborhoods;Outcome;pandemic disease;Poverty;prevent;Primary Care;primary care practice;primary health service;Problem Solving;Process;Provider;provider factors;Public Health Schools;Quality of Care;Quality of life;racism;Randomized;research study;Resources;Risk;safety net;scale up;screening;Sequential Multiple Assignment Randomized Trial;Services;Site;skills;social;social stigma;Social Work;socioeconomic disparity;socioeconomics;Stress;stressor;Support System;supported housing;syndemic;System;technological innovation;Technology;Testing;Time;Training;trial design;United States;United States National Institutes of Health;uptake;Use Effectiveness;vulnerable community;Work

PROJECT_TITLE: Harlem Strong Mental Health Coalition: A Multi-sector Community-Engaged Collaborative for System Transformation


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Heart Disease;Pediatric;Pediatric Cancer;Physical Activity;Physical Rehabilitation;Prevention;Rare Diseases;Rehabilitation;Telehealth

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: Survivors of childhood cancer in their thirties have exercise capacity that mirrors values found among older adults in the general population. This proposal tests the efficacy of an individually prescribed telehealth-based exercise intervention on exercise capacity in this population. This study has potential to move standard of care (encouraging physical activity) for exercise intolerance from its’ current state, where it is ineffective for most survivors, to a clinically actionable, practical, sustainable, and generalizable intervention.

PI_NAMEs: MULROONEY, DANIEL A.;NESS, KIRSTEN KIMBERLIE (contact)

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: Accounting;active lifestyle;Activities of Daily Living;Adherence;Adopted;Adult;Aerobic;Age;American;Anthracycline;anti-cancer research;attentional control;Behavioral;Body System;Cardiac;Cardiology;Cardiomyopathies;cardiovascular health;cardiovascular risk factor;chemotherapy;Chest;childhood cancer survivor;Chronic;Client;Clinical;clinically actionable;cognitive function;cognitive reserve;cohort;Communities;Control Groups;cost;daily functioning;Data;Demographic Factors;design;Dose;Educational Intervention;efficacy evaluation;efficacy testing;Eligibility Determination;Emotional;emotional distress;Environment;Exercise;exercise capacity;exercise intervention;exercise intolerance;Exercise Physiology;exercise prescription;Exercise Tolerance;experience;Family;follow-up;Foundations;Funding;Future;General Population;group intervention;Health;Home;Hour;Impairment;implementation science;improved;Individual;Instruction;Internal Medicine;Intervention;Life;Longevity;Lung;Malignant Childhood Neoplasm;Measures;Metabolic;mobile application;Monitor;mortality;Motivation;multidisciplinary;muscle form;Musculoskeletal;neuromuscular;neurosensory;older adult;Oncology;Online Systems;Oxygen;Participant;Persons;Physical activity;physical inactivity;Population;Prevalence;programs;Psychology;Quality of life;Radiation;Randomized;remediation;remote delivery;Reporting;response;Risk;Role;sex;Smoking Status;Specialist;standard of care;strength training;Strenuous Exercise;success;Supervision;Survival Rate;Survivors;survivorship;telehealth;therapy design;Thinness;Time;tool;Training;uptake;Videoconferencing;Visit;young adult

PROJECT_TITLE: Telehealth based exercise intervention to improve functional capacity in survivors of childhood cancer with significantly limited exercise tolerance


NIH_SPENDING_CATS: Childhood Obesity;Diabetes;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Pregnancy;Prevention;Women's Health Research

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: PROJECT NARRATIVE This proposal leverages a very well characterized and deeply phenotyped cohort of mother-offspring pairs to investigate different biological pathways by which the in utero environment may confer risk of obesity-related conditions in offspring during childhood. It will explore the relevance of metabolic subtypes during pregnancy, as a means to identify nuances in metabolism that are related to maternal fuels implicated in fetal programming (e.g., glucose, insulin, lipids) lifestyle intervention targets (e.g., diet, physical activity), placental signaling, and offspring’s metabolic profile. Findings from this study will improve knowledge of in utero risk stratification, maternal and child metabolic pathways involved in early life cardiometabolic risk and could reveal targets for prevention strategies to interrupt the transgenerational cycle of diabetes and obesity.

PI_NAMEs: FRANCIS, ELLEN CROSS (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: 5 year old;8 year old;Address;adipokines;Amino Acids;Behavioral;Biochemical;Biological;Biological Assay;Biological Markers;Biology;Birth;Blood;Blood Pressure;Body mass index;Cardiometabolic Disease;cardiometabolic risk;career;Child;Childhood;Cholesterol;Chorionic villi;circulating biomarkers;Clinical;cohort;Complex;Data;detection of nutrient;Development;Developmental Biology;Diabetes Mellitus;Diet;disorder risk;early-onset obesity;Environment;Exposure to;Fasting;Fatty acid glycerol esters;Fatty Acids;fetal;Fetal Development;fetal programming;FRAP1 gene;Gestational Diabetes;Glucose;Health;Heterogeneity;high dimensionality;Hyperglycemia;improved;in utero;Infant;Instruction;Insulin;Insulin Signaling Pathway;Interruption;Knowledge;Life;Life course epidemiology;Life Cycle Stages;Life Style;lifestyle data;lifestyle intervention;Lipids;maternal condition;maternal obesity;Mediating;Mentors;Metabolic;Metabolic Diseases;Metabolic Pathway;metabolic profile;Metabolism;metabolomics;modifiable behavior;Mothers;novel;Obesity;obesity risk;obstetrical complication;offspring;offspring obesity;Overnutrition;Participant;Pathology;Pathway interactions;Perinatal;Phase;Phenotype;phenotypic data;Phosphorylation;Physical activity;Physiological Adaptation;Placenta;Placental Biology;Plasma;Pregnancy;Pregnant Women;prenatal;prepregnancy;Prevention strategy;Principal Component Analysis;Process;Proteins;Research;Research Personnel;Resource Allocation;Resources;response;Risk;risk stratification;Role;Sampling;Serum;Severities;Signal Pathway;Signal Transduction;Subgroup;symposium;Techniques;Testing;Tissues;Training;Triglycerides;unsupervised clustering;Woman;Youth

PROJECT_TITLE: Characterizing metabolic variability during pregnancy to understand pathways of in-utero overnutrition: an integrative analysis of metabolomics and lifestyle data

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Children with substantial African ancestry have long been known to have half or less the rate of acute lymphoblastic leukemia (ALL) than do children with other continental ancestries. We will conduct admixture mapping of ALL risk and outcome in African-American patients. The proposed research will potentially answer a long-standing mystery by revealing critical genes or loci that explain the comparative deficit of B-cell ALL in AA compared to EA children, possibly pointing towards prevention.

PI_NAMEs: SCHEURER, MICHAEL E.;SPECTOR, LOGAN G. (contact)

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: Accounting;Acute Lymphocytic Leukemia;Admixture;admixture mapping;African;African American;African ancestry;Alleles;American;B-Cell Acute Lymphoblastic Leukemia;Birth;Birth Weight;Body mass index;Candidate Disease Gene;Cause of Death;CEBPE gene;Central Nervous System;Characteristics;Child;Clinical;comparative;Confidence Intervals;Data;Diagnosis;Disease;disorder risk;DNA;Environment;Environmental Risk Factor;European;European ancestry;Exposure to;GATA3 gene;Gene Frequency;Genes;Genetic;genetic architecture;genetic variant;Genome;genome wide association study;genomic locus;Genotype;high risk;Immunophenotyping;improved outcome;in silico;In Vitro;Incidence;Inherited;International;Life;Link;Maintenance Therapy;Malignant Neoplasms;Maps;Maternal Age;Mediation;Modeling;multi-ethnic;novel;Odds Ratio;offspring;Outcome;Parents;Patients;Perinatal;pharmacogenetic variants;Population Study;Prevention;Race;Registries;relapse risk;Research;Residual state;Risk;Risk Factors;risk variant;Sampling;Single Nucleotide Polymorphism;Socioeconomic Status;success;survival disparity;Techniques;Testing;United States;Variant;White Blood Cell Count procedure

PROJECT_TITLE: Admixture analysis of acute lymphoblastic leukemia in African American children: the ADMIRAL Study

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BELLEFONTE

ORG_NAME: ACTUATED MEDICAL, INC.

PHR: Project Narrative: Relevance – Loss of bladder or bowel control, generally known as urinary or bowel incontinence, respectively, are conditions with many etiologies that are not only debilitating and embarrassing for the millions affected but are also very costly to the healthcare and workforce sectors. Sacral nerve stimulation (SNS) is an effective, minimally invasive treatment for otherwise intractable cases, or those that do not respond to conservative treatments such as pharmacotherapies. However, placement of the leads that innervate the muscles for the bladder or bowel is a complex, highly precise process in which insufficient response from lead stimulation has suspended implantation in up to 76% of cases in some studies. This Phase I project addresses the shortcomings in imaging and visualization of soft tissues behind bone by developing a guidance tool with a photoacoustic ‘eye in the needle’ approach to better place SNS leads with millimeter-level accuracy adjacent to the nerve, resulting in more successful and reliable treatment for patients.

PI_NAMEs: BAGWELL, ROGER BROOKS (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Achievement;Address;Affect;Anatomy;Award;Bladder;Bladder Control;Blurred vision;bone;Cadaver;Catheterization;Catheters;Certification;Clinic;Clinical;clinical efficacy;Clinical Research;college;commercialization;Complex;cost;design;Detection;Devices;Effectiveness;efficacy evaluation;Electrodes;Ensure;Enteral Feeding;Etiology;Evaluation;experience;Eye;Failure;failure Implantation;Fecal Incontinence;Fluoroscopy;Goals;Health Care Costs;Health Personnel;Healthcare;Hospitals;Hypertension;Image;imaging modality;Implant;implantation;improved;In Vitro;in vivo;Incontinence;innovation;Intestines;Lasers;Lateral;Lead;Length;Life;Longitudinal Studies;Marketing;Medical;Medical center;Medical Device;Medicine;Methodology;millimeter;minimally invasive;Minimally Invasive Surgical Procedures;Muscle;Muscle Tension;Needles;Nerve;neural;Neurosciences;Noise;novel;Operative Surgical Procedures;Optics;Outcome;Patients;Pelvic Floor Muscle;Pelvis;Performance;Persons;Pharmacotherapy;Phase;Physicians;Population;pre-clinical;preclinical study;Procedures;Process;Reporting;Resolution;response;Sacral nerve;sacrum;Safety;Sales;Severities;side effect;Small Business Innovation Research Grant;social stigma;soft tissue;sphincter ani muscle structure;Standardization;statistics;stem;Sterility;success;System;Techniques;Technology;Testing;tool;Transducers;transmission process;ultrasound;United States National Institutes of Health;urinary;Urinary Incontinence;Urinary tract infection;Validation;Visualization;Water

PROJECT_TITLE: Photoacoustic Tool to Improve Visualization and Success Rates in Sacral Neural Modulation Lead Placement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-R (11)]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine

PHR: Narrative The All of Us Research Program aims to collect data from a diverse group of participants in the United States with an overrepresentation of traditionally underrepresented groups. However, there are disparities in disease prevalence compared to the broader U.S. population, limiting the ability of researchers to test hypotheses that could apply to the U.S. population. To improve the generalizability of the data and expand their impact, this proposal aims to develop, assess, and refine synthetic sampling weights for the All of Us Research Program data by leveraging external data resources from the U.S. population.

PI_NAMEs: CHEN, QINGXIA  (contact);CRONIN, ROBERT M

PROGRAM_OFFICER_NAME: HUELSNITZ, CHLOE OLIVIA

PROJECT_TERMS: Affect;All of Us Research Program;American;Baseline Surveys;Biomedical Research;Calibration;Case Study;Censuses;cohort;Cohort Studies;Collaborations;Community Surveys;Compensation;Complex;Data;data resource;Data Set;design;disability;Disclosure;Disease;Disparity;Effectiveness;effectiveness evaluation;Ethnic Origin;Gender;Geographic Locations;Geography;Goals;Housing;Hypertension;improved;Individual;Literature;Longitudinal cohort;machine learning method;Masks;Methodology;Methods;multimodal data;National Health and Nutrition Examination Survey;Obesity;Participant;Phenotype;Population;Prevalence;Probability;Publishing;racial difference;recruit;Research Personnel;response;Risk;Sample Size;Sampling;statistical learning;Statistical Methods;statistics;Surveys;Target Populations;Testing;Underrepresented Populations;United States;Weight;Work

PROJECT_TITLE: DARSaW: Developing, Assessing, and Refining Synthetic Sampling Weights to Improve Generalizability of the All of Us Research Program Data


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE The project proposed here is relevant to public health for two reasons. First, it can guide the development of more equitable public health policies for infectious diseases. Second, it can lead to the discovery of novel biomarkers or drugs for infectious diseases which in turn can reduce the burden of infectious diseases.

PI_NAMEs: ASGARI, SAMIRA  (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: Accounting;admixture mapping;Affect;Behavioral;biobank;Biology;burden of illness;Categories;clinical care;Code;cohort;Communicable Diseases;Communities;Complex;COVID-19 disparity;Data;Data Set;Development;Diagnostic tests;Disease;disease phenotype;Disparity;Economics;Electronic Health Record;Environmental Risk Factor;epidemiology study;Equity;ethnic difference;ethnic disparity;ethnic minority;Ethnic Origin;Ethnic Population;experience;Future;Gene Expression;Genetic;genetic analysis;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;genetic variant;Genome;genome sequencing;genome wide association study;Genomic Segment;Genotype;Geography;Goals;health care availability;health disparity;Health Policy;Hepatitis;HIV;HIV/AIDS;Human;Human Genetics;human genomics;improved;in silico;Inequality;insight;inter-individual variation;Justice;Life Style;low socioeconomic status;Malaria;Names;novel;novel diagnostics;novel marker;novel therapeutics;Participant;pathogen;Patient Self-Report;Pharmaceutical Preparations;Population;Population Group;Population Heterogeneity;Positioning Attribute;Predisposition;Prevalence;Public Health;Race;racial difference;racial disparity;racial minority;Rare Diseases;rare variant;Recording of previous events;Research Personnel;Residual state;Resources;Respiratory Tract Infections;Risk Factors;risk variant;Role;Sepsis;Sexually Transmitted Diseases;Shapes;social disparities;Societies;sociodemographic factors;sociodemographic variables;sociodemographics;Socioeconomic Status;socioeconomics;Stratification;Structural Racism;Structure;Surveys;Susceptibility Gene;Testing;Tuberculosis;Variant;whole genome;Work

PROJECT_TITLE: Identifying genetic and sociodemographic determinants of susceptibility to infectious diseases in diverse population groups


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_NAME: TENNESSEE STATE UNIVERSITY

PHR: Project Narrative  Assessment needs of research administrative support and services and physical infrastructure that inform action plans have not been appropriately investigated and are essential to the NIH mission for disease prevention, treatment, cures.

PI_NAMEs: QUICK, QUINCY ANTOINE (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Administrator;Agriculture;Award;Behavioral;Behavioral Research;Biomedical Research;biomedical scientist;Capital;Data;Development;disorder prevention;Ecosystem;Effectiveness;Expenditure;Faculty;Focus Groups;Foundations;Funding;Grant;Grant Review;Historically Black Colleges and Universities;improved;Infrastructure;innovation;Institution;Laboratories;Leadership;Methodology;Mission;Monitor;Needs Assessment;novel;Procedures;Process;Productivity;Recording of previous events;Reporting;Reproducibility;Research;research and development;research facility;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Science;Services;Source;Surveys;teacher;Techniques;Tennessee;tool;United States Department of Agriculture;United States National Institutes of Health;Universities

PROJECT_TITLE: Tennessee State University Needs Assessment and Five Pillar Strategic Action Plan