ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Genetics;Hearing Loss;Neurosciences;Prevention;Rehabilitation;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: INDIANAPOLIS

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Hearing loss affects more than 35 million adults and children in the United States and genetic variants play a major role in the survival of sensory cell within the inner ear. This project is directed at understanding how TMPRSS3, a protein that cuts other proteins, regulates the critical protein links around the sensory cells. The results may help us design strategies for treating inherited deafness.

PI_NAMEs: NELSON, RICK F (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: 3-Dimensional;Adaptor Signaling Protein;Address;Adult;Affect;Apical;Audiology;Biochemical;Biological;Cell Death;Cell Physiology;Cell Survival;Cells;Cessation of life;Charge;Child;Cochlea;Cochlear Implants;curative treatments;Cut protein;Data;deafness;design;Development;electrical potential;Endolymph;Epitopes;Frequencies;Gene Delivery;Gene Mutation;Gene Proteins;Genes;Genetic Complementation Test;genetic deafness;genetic variant;Genotype;Goals;Hair Cells;Hearing;hearing impairment;hereditary hearing loss;Hour;Human;human stem cell-derived;In Vitro;in vivo;insight;Knowledge;Labyrinth;Link;link protein;Location;Mammalian Genetics;Mediating;Membrane;Molecular;mouse model;multiple omics;mutant;mutant mouse model;Mutant Strains Mice;Mutation;novel;Organ of Corti;Organoids;overexpression;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pattern;Peptide Hydrolases;Perilymph;Permeability;Phenotype;Physiological;Play;postnatal;Potassium;preservation;prevent;Preventive treatment;Process;protein complex;Protein Truncation;Proteins;Proteolysis;Proteomics;Regulation;Reporting;Role;Sensory;Sensory Hair;Serine Protease;Side;single-cell RNA sequencing;targeted treatment;Techniques;Testing;Tight Junctions;transcriptomics;treatment strategy;United States;Variant;Work

PROJECT_TITLE: Mechanisms of Mammalian Genetic Hearing Loss

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: JOSLIN DIABETES CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE This project will determine how gut bacteria, known as the gut microbiome, can influence the health benefits of regular physical exercise. We will test whether specific types of gut bacteria can act in conjunction with exercise training to enhance improvements in metabolic health in mouse models of disease with high blood sugar levels. We anticipate this work will lead to development of a “probiotic” treatment to improve health and the response to exercise training in people with metabolic diseases like type 1 and type 2 diabetes.

PI_NAMEs: KOSTIC, ALEKSANDAR DAVID (contact);LESSARD, SARAH

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acute;Aerobic;Aerobic Exercise;Affect;Bacteria;Biological Response Modifier Therapy;Blood Glucose;blood glucose regulation;calmodulin-dependent protein kinase II;Carbon;Chronic;Coupled;Couples;Data;Defect;Development;Diabetes Mellitus;Diet;disease model;Exercise;exercise capacity;exercise intensity;exercise training;exhaustion;experience;Fermentation;FFAR2 gene;Fiber;glucose metabolism;glucose uptake;glycemic control;Glycogen;Gnotobiotic;GTP-Binding Proteins;gut bacteria;gut microbes;gut microbiome;gut microbiota;Health;Health Benefit;Human;Hyperglycemia;impaired glucose tolerance;Impairment;improved;In Vitro;in vivo;Individual;Injections;Insulin Resistance;insulin secretion;insulin sensitivity;knock-down;Lead;Measures;Mediating;Mediator;Metabolic;Metabolic Diseases;Metabolism;microbial;Microbiology;microbiome;Modeling;Molecular;mouse model;Mus;Muscle;Muscle function;muscle metabolism;Muscle Mitochondria;Nonesterified Fatty Acids;novel;oxidation;Pathology;Performance;Persons;Physical Exercise;Play;Prediabetes syndrome;probiotic therapy;Production;Propionates;receptor;Rectal Administration;response;Role;Running;sedentary;Serum;Signal Transduction;Site;Skeletal Muscle;skeletal muscle metabolism;Source;Supplementation;Testing;Time;Tissues;Training;treadmill;type I and type II diabetes;Veillonella;Volatile Fatty Acids;Work

PROJECT_TITLE: Gut microbial fermentation products of muscle-derived lactate as mediators of exercise and metabolism

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROGRAM NARRATIVE Achieving long-term survival of organ transplants without the need for lifelong immunosuppression will provide transplant recipients with healthier and longer lives. These studies will explore ways to eliminate the need for chronic immunosuppressive drugs in patients undergoing lung transplantation.

PI_NAMEs: MADSEN, JOREN C (contact)

PROGRAM_OFFICER_NAME: SHAW, JULIA M

PROJECT_TERMS: Acute;Address;Allograft Tolerance;Allografting;Antibodies;Autoimmune Diseases;BCL2 gene;Biological;Biological Assay;Bone Marrow Diseases;Bone Marrow Transplantation;career;Cell Therapy;Chimerism;Chronic;Clinical;clinical application;clinical translation;clinical trial readiness;Collaborations;Computer Analysis;conditioning;Cytomegalovirus Infections;Dedications;Engineering;Environment;experimental study;FDA approved;Fertilization;Flow Cytometry;Funding;Gene Modified;Goals;Hematopoietic;Human;Immune system;Immunity;Immunogenetics;immunoregulation;Immunosuppression;Immunosuppressive Agents;improved;innovation;insight;kidney allograft;Life;Lung;lung allograft;lung basal segment;Lung Transplantation;Lymphoproliferative Disorders;Molecular Immunology;Monoclonal Antibodies;Myelosuppression;nanoparticle;nanotherapy;next generation;nonhuman primate;novel strategies;Organ;Organ Survival;Organ Transplantation;Patients;Pharmaceutical Preparations;Physicians;Play;post-transplant;Preparation;Procedures;programs;Protocols documentation;Radiation;Regulation;Regulatory T-Lymphocyte;Research Personnel;Resistance;Risk Reduction;Sampling;Solid;statistics;Stress;Sum;synergism;Testing;Time;Toxic effect;Training;transcriptomics;Transplant Recipients;Transplant Surgeon;Transplant-Related Disorder;Transplantation;Transplantation Tolerance;virology;Whole-Body Irradiation

PROJECT_TITLE: Novel Approaches to Inducing Lung Allograft Tolerance in NHPs


PROJECT_TERMS: Advisory Committees;Allograft Tolerance;animal data;Bibliography;Biometry;Clinical Trials;Communication;Consultations;Data Analyses;data exchange;design;experience;Floor;Funding;General Hospitals;Goals;Grant;Hospitals;Human Resources;Institution;Joints;lung allograft;Manuscripts;Massachusetts;medical schools;Medicine;meetings;novel strategies;Preparation;professor;programs;Progress Reports;Publications;Reporting;Research;Research Design;Research Personnel;Resources;Sample Size;Science;Solid;Structure;symposium;transplant centers;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Dietary Supplements;Infectious Diseases;Microbiome;Nutrition;Prevention

ORG_CITY: LOUISVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE Published and preliminary results demonstrate that vitamin D can increase the immune defenses of gingival cells against the bacteria associated with periodontal disease. Here we propose to examine the role of vitamin D in periodontal disease in a mouse model, and to study the mechanism by which this occurs. The results will support the development of vitamin D as a therapy for periodontal disease and other oral infections.

PI_NAMEs: DIAMOND, GILL  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: 3-Dimensional;absorption;Actinobacillus actinomycetemcomitans;Address;Affect;Anti-Bacterial Agents;antimicrobial;Apical;Bacteria;Bioinformatics;Bone Development;bone loss;Bone Resorption;Calcium;cathelicidin antimicrobial peptide;Cells;Cholecalciferol;Chronic;Clinical;Clinical Trials;commensal microbes;Complex;cytokine;cytotoxicity;Data;Development;dysbiosis;Epigenetic Process;Epithelial Cells;Epithelium;Feedback;Genes;Genetic;Gingiva;Growth;Health;Health Status;Homeostasis;Host Defense;Human;Immune;Immunity;In Vitro;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Inflammatory Response Pathway;Kinetics;Link;Mechanics;Mediating;Mixed Function Oxygenases;Molecular;mouse model;Mus;Natural Immunity;Operative Surgical Procedures;Oral;Oral cavity;oral cavity epithelium;oral infection;oral microbial community;oral microbiome;oral supplementation;Outcome;pathogenic bacteria;Pathway interactions;Peptides;Periodontal Diseases;Periodontitis;periodontopathogen;Population;Porphyromonas gingivalis;prevent;Preventive therapy;Production;Publishing;Regulation;Reporting;response;Role;Signal Pathway;supervitaminosis;Surface;three dimensional cell culture;Tissues;Tooth Loss;Topical application;Toxic effect;transcription factor;Vitamin D;Vitamin D Deficiency;Vitamin D supplementation;Vitamin D3 Receptor;Vitamins

PROJECT_TITLE: Topical Vitamin D and Periodontal Disease


PI_NAMEs: KEAN, LESLIE S (contact)

PROJECT_TERMS: Address;Allograft Tolerance;Animals;Automobile Driving;Bioinformatics;bioinformatics pipeline;Biological;Biological Assay;Bone Marrow;Boston;cell type;Cells;Clinic;clinically relevant;Clone Cells;Collaborations;Complex;Computer Analysis;Computer software;Cytomegalovirus;Dana-Farber Cancer Institute;data management;Data Set;Development;Disparity;Ensure;experimental study;Flow Cytometry;General Hospitals;Graft Rejection;high dimensionality;Hospitals;Human Herpesvirus 4;Immune;Immune response;Immune system;Immune Tolerance;Immunity;Immunogenetics;Immunologic Monitoring;Immunology;Immunology procedure;Information Management;Lead;Link;Lung;lung allograft;Lung Transplantation;Macaca;Macaca fascicularis;Macaca mulatta;Massachusetts;medical schools;Methodology;Minnesota;Molecular;Molecular Analysis;Molecular Immunology;Monitor;novel;novel strategies;novel therapeutic intervention;Outcome;Pathway interactions;Pediatric Hospitals;Performance;Physicians;Procedures;Regimen;Reproducibility;Research;Research Personnel;Safety;Sampling;Scientist;single-cell RNA sequencing;spatiotemporal;Stains;Standardization;synergism;System;Systems Analysis;T cell infiltration;T-Lymphocyte;Techniques;tool;transcriptomics;Translating;Transplant Recipients;Transplantation;Transplantation Tolerance;Universities;Viral;viral detection;virology;Virus;Virus Latency;Woman

PROJECT_TITLE: Molecular Immunology Core


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Mali is a low-income country in Sub-Saharan West Africa where the incidence of mycobacterial infections, primarily tuberculosis, remains high driven in a large part by the persistence of the HIV epidemic with TB being the main cause of death in HIV-infected adults and children. The overarching goal of this research training program, “Building the Next Generation of Researchers in HIV/TB Diagnostics in Mali”, is to strengthen the scientific capacity to develop and implement diagnostic and monitoring technologies to address the HIV and TB epidemics. Through this program, we will achieve the overall goal of training the next generation of scientists and leaders in diagnostics of HIV and mycobacterial diseases in Mali and the region.

PI_NAMEs: MAIGA, ALMOUSTAPHA ISSIAKA;MURPHY, ROBERT LEO (contact);SYLLA, MARIAM

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Adult;Africa;antiretroviral therapy;Award;Biological Assay;Biomedical Engineering;career development;Child;Clinical;Collaborations;community setting;Detection;Device or Instrument Development;Diagnosis;Diagnostic;Disease;Doctor of Philosophy;Engineering;Environment;Epidemic;Faculty;Goals;Grant;Guidelines;HIV;HIV diagnosis;HIV drug resistance;HIV/AIDS;HIV/TB;Immunology;improved;Incidence;Income;low income country;Mali;Master of Science;Microbiology;Molecular Biology;Monitor;mycobacterial;Mycobacterium Infections;next generation;non-tuberculosis mycobacteria;Outcome;Peer Review;Productivity;programs;Public Health;Publications;Recommendation;Reduce health disparities;Research;Research Methodology;Research Personnel;Research Training;Schools;Science;Scientist;screening;success;Techniques;Technology;Testing;tool;Training;Training Programs;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;underserved community;United States National Institutes of Health;Universities;Validation;virology;World Health Organization

PROJECT_TITLE: Building the Next Generation of Researchers in TB/HIV Diagnostics in Mali (B-NextGen)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE 20-25% of AML have very high expression of a gene called Meningioma-1 (MN1), and most of these patients have a very poor prognosis, thus substantially contributing to over 10,000 deaths from AML/year in the US. We hypothesize that MN1 causes AML primarily by stabilizing gene regulatory hubs via intrinsically disordered, “sticky” domains. Dissecting how MN1 achieves this will yield fundamental insights into gene regulation and may point the way towards novel and innovative therapies targeting intrinsically disordered domains.

PI_NAMEs: BERNT, KATHRIN M (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;Affect;Affinity;Amino Acid Sequence;Amino Acids;Androgen Receptor;Binding;Cells;Cessation of life;Chromatin;Code;Complex;Disease;Dose;Enhancers;Epigenetic Process;Estrogen Receptors;Ewings sarcoma;EWS-FLI1 fusion protein;experimental study;Frequencies;Gene Expression Regulation;Genes;Genetic Transcription;Hematopoietic;Hematopoietic stem cells;inhibitor;Innovative Therapy;insight;Kinetics;leukemia;leukemia treatment;Leukemic Cell;Liquid substance;loss of function;Malignant - descriptor;Malignant Neoplasms;Mediating;member;Membrane;Meningioma-1;Microscopy;Modeling;Mus;Mutation;Myeloid Progenitor Cells;Nephroblastoma;Nerve Degeneration;notch protein;NOTCH1 gene;novel strategies;novel therapeutics;Nuclear;Nucleosomes;Oncogenes;Oncogenic;Organelles;Outcome;overexpression;patient population;Patients;Peptides;Phase Transition;Physical condensation;physical property;Physiological;polyglutamine;Positioning Attribute;preservation;progenitor;Prognosis;programs;promoter;Property;Proteins;recruit;Reporting;Series;Site;stem;stem cells;Stretching;Structure;System;targeted treatment;Testing;Theoretical model;Therapeutic;transcription factor;tumorigenesis;Variant

PROJECT_TITLE: IDP mediated transcriptional stabilization as a cause of AML

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


PROJECT_TERMS: Allograft Tolerance;cooperative study;Ensure;Expenditure;Funding;Funding Opportunities;Infrastructure;lung allograft;Monitor;National Institute of Allergy and Infectious Disease;nonhuman primate;novel strategies;Procedures;programs;Reporting;Structure;Transplantation Tolerance;web site

PROJECT_TITLE: Infrastructure and Opportunities Fund Management Core


PHR: PROJECT NARRATIVE Achieving long-term survival of organ transplants without the need for lifelong immunosuppression will provide transplant recipients with healthier and longer lives. These studies will explore ways to eliminate the need for chronic immunosuppressive drugs in patients undergoing lung transplantation.

PROJECT_TERMS: Acute;Address;allograft rejection;Allograft Tolerance;Antibodies;Antigens;Apoptosis;Autoimmune Diseases;B-Lymphocytes;BCL2 gene;Biological Assay;Bone Marrow Diseases;Bone Marrow Transplantation;Chimerism;Chronic;clinical application;clinical translation;clinical trial readiness;conditioning;Cytomegalovirus Infections;Data;design;Dose;Epigenetic Process;Eragrostis;experience;Exposure to;FDA approved;Fertilization;Funding;Gene Modified;Generations;Goals;Hematopoietic;High Density Lipoprotein therapy;High Density Lipoproteins;Human;Immune;Immunity;Immunologic Memory;Immunology;immunoregulation;Immunosuppression;Immunosuppressive Agents;infection risk;Inflammatory;insight;Kidney;kidney allograft;Life;Lipoproteins;Lung;lung allograft;Lung Transplantation;Lymphoproliferative Disorders;Macrophage;Metabolic;Molecular Immunology;Monoclonal Antibodies;mTOR inhibition;mTOR Inhibitor;Myeloid Cells;Myelosuppression;nanobiologic;nanoparticle;nanoparticle delivery;nanotherapy;next generation;nonhuman primate;novel strategies;Organ;Organ Survival;Organ Transplantation;Patients;Pharmaceutical Preparations;Play;post-transplant;preimplantation;prevent;programs;Protocols documentation;Radiation;Regulatory T-Lymphocyte;Resistance;Risk Reduction;Role;Sirolimus;statistics;Stress;System;T memory cell;T-Lymphocyte;Testing;Time;Toxic effect;Training;Transplant Recipients;Transplant-Related Disorder;Transplantation;Whole-Body Irradiation

PROJECT_TITLE: Project 1: Next Generation Mixed Chimerism Strategies to Induce Lung Allograft Tolerance in NHPs


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Hearing Loss;Neurodegenerative;Neurosciences;Pediatric;Peripheral Neuropathy;Rehabilitation

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Access to high-quality auditory input is crucial to the development of spoken language in children with hearing loss. Additional understanding of the perceptual consequences of Auditory Neuropathy and Cochlear Hearing Loss in school-age children is a first step to developing future audiologic treatments and optimizing best practices for maximizing speech perception outcomes in these populations. The proposed project aims to evaluate spectral and temporal resolution abilities and their relationship to phonological processing and speech perception in children with Auditory Neuropathy and Cochlear Hearing Loss.

PI_NAMEs: KANE, STACEY LYNN GOEBEL (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Accounting;Acoustics;Acute;Adult;Affect;Area;Audiology;Auditory;auditory neuropathy;boys;career development;career networking;Characteristics;Child;Clinical;Clinical Protocols;Cochlear Hearing Loss;Complex;Cues;Data;Detection;Development;Ethics;Etiology;Evaluation;Exhibits;Fellowship;Frequencies;Future;Goals;Hearing Aids;hearing impairment;Hospitals;Impairment;improved;Intervention;Knowledge;Language;Language Development;language perception;lexical;Long-Term Effects;Modeling;normal hearing;North Carolina;Outcome;peer;Perception;Performance;Peripheral;Phonetics;phonological awareness;phonology;Population;programs;Property;Protocols documentation;Psychophysics;Research;research clinical testing;Research Design;Resolution;Risk;School-Age Population;Sensorineural Hearing Loss;Signal Transduction;simulation;skill acquisition;skills;Speech Development;Speech Perception;speech recognition;Statistical Models;Structure;syntax;temporal measurement;Testing;Time Perception;Training;University resources;Vocabulary;word learning;Work

PROJECT_TITLE: Effects of Auditory Neuropathy and Cochlear Hearing Loss on Speech Perception


ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Although HIV infection can be controlled by daily lifelong adherence to expensive antiretroviral ARV therapies, it cannot presently be cured. While infected cells often hide from the immune system in latency, converging evidence supports that these may also be seen by cytotoxic T-cells but are able to resist being killed. This proposal will address the unmet need of identifying and overcoming mechanisms of cell-intrinsic resistance to cytotoxic T-cells in persistent HIV reservoirs, with the aim of developing new therapeutic approaches to curing infection.

PI_NAMEs: JONES, R. BRAD  (contact);SANJANA, NEVILLE

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Adherence;antagonist;Anti-Retroviral Agents;Antigens;antiretroviral therapy;Area;Automobile Driving;BCL1 Oncogene;Biological Assay;Biological Process;CD4 Positive T Lymphocytes;Cell Death;cell killing;Cell Survival;cell type;Cells;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;comorbidity;CRISPR screen;Cytotoxic T-Lymphocytes;Data;Data Set;Epidemic;Essential Genes;Expanded CRISPR-compatible cellular indexing of transcriptomes and epitopes by sequencing;Exposure to;Expression Profiling;Foundations;Freedom;Genes;genome-wide;Granzyme;Health Benefit;HIV;HIV Infections;HIV resistance;Immune response;Immune system;Immune Targeting;immunogenic;Immunooncology;Immunotherapy;improved;In Vitro;in vivo;Infection;Inflammation;inhibitor;innovation;Knock-out;Leadership;loss of function;Mediating;Membrane Proteins;Modernization;Molecular;mouse model;neoplastic cell;new therapeutic target;novel therapeutic intervention;Outcome;overexpression;Pathway interactions;Persons;Pharmaceutical Preparations;Play;Population;pre-clinical;preclinical evaluation;Predisposition;Productivity;Property;protein expression;protein profiling;Public Health;Publishing;Reporting;research clinical testing;Resistance;resistance mechanism;RNA Interference;Screening Result;Seminal;Series;small molecule inhibitor;social stigma;success;synergism;Testing;Therapeutic;therapeutic candidate;therapeutic target;tool;Toxic effect;Transcript;transcriptomics;translational approach;tumor;Validation;Viral;Virus

PROJECT_TITLE: Enhancing Susceptibility of HIV Reservoirs to CTL Through a Discovery to Translational Approach


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The Cancer Center Support Grant (CCSG) provides support for the Holden Comprehensive Cancer Center (HCCC) that is used to leverage the HCCC's strong culture of transdisciplinary cancer research including collaborative basic, clinical and population-based cancer research. The CCSG also supports the HCCC as it translates cancer research advances to the clinic and community with the goal of reducing the morbidity and mortality of cancer in the catchment area of the HCCC (the state of Iowa) and beyond.

PI_NAMEs: BURKARD, MARK E (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Address;Agonist;anti-cancer research;Area;ascorbate;Basic Cancer Research;Basic Science;Biometry;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer epidemiology;Cancer Etiology;cancer prevention;Cancer Research Infrastructure;cancer therapy;career;Catchment Area;Clinic;Clinical;Clinical Investigator;clinical practice;Clinical Protocols;Clinical Research;Clinical Services;Clinical Trials;Collaborations;collaborative environment;college;Communications Media;Communities;community advisory board;community engagement;Community Outreach;Comprehensive Cancer Center;design;Diagnostic;Disparity;DNA Repair;Dose;early phase clinical trial;Education;Environment;epidemiology study;Evaluation;evidence base;Flow Cytometry;Free Radicals;fundamental research;Funding;Genomics;Goals;Grant;high throughput screening;Holden Comprehensive Cancer Center at the University of Iowa;Human Papilloma Virus Vaccination;Image;improved;Infrastructure;innovation;Institution;interdisciplinary collaboration;Investigational Therapies;Iowa;Laboratories;Lymphoma;Malignant Neoplasms;Measures;meetings;member;Metabolism;Microscopy;Mission;Molecular Epidemiology;Monitor;Morbidity - disease rate;mortality;NCI-Designated Cancer Center;notch protein;novel therapeutics;Obesity;Oncogenes;Pain;Pathway interactions;Peer Review;Persons;pharmacologic;population based;Population Research;Population Sciences;Process;programs;protocol development;Protocols documentation;Publications;Publishing;Radiation;recruit;Research;Research Infrastructure;Research Personnel;Research Support;Resource Sharing;Resources;Rural;rural setting;rurality;Science;Scientific Advances and Accomplishments;Scientist;Specialized Program of Research Excellence;Structure;symposium;Teenagers;Testing;theranostics;TLR9 gene;Training;Translating;Translational Research;Universities;Viral Vector

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


PHR: PROJECT NARRATIVE The current half-life of a lung allograft is unacceptably short, and all recipients encounter significant complications, both from allograft rejection and from immunosuppression-associated toxicities. Given these issues, the ultimate goal of lung transplant is immune tolerance-induction, which promises life-long graft acceptance without chronic immunosuppression, and with maintenance of protective immunity against viruses and other infections. The proposed research is highly relevant to public health because it aims to improve clinical outcomes for patients that are undergoing lung transplantation, by discovering new strategies to induce immune tolerance.

PROJECT_TERMS: Ablation;Address;allograft rejection;Allograft Tolerance;Antibodies;Antibody-drug conjugates;Antigens;Area;Autoimmune Diseases;base editing;Biotechnology;Bone Marrow;Calcineurin inhibitor;Cell Therapy;Characteristics;chemotherapy;chimeric antigen receptor;Chimerism;Chronic;Clinical;clinical translation;conditioning;Data;Defect;design;Development;Drug Kinetics;Engineering;Environment;Equilibrium;evidence base;FOXP3 gene;Goals;graft vs host disease;Half-Life;high risk;Human;Immune;Immune Targeting;Immune Tolerance;Immunity;Immunomodulators;immunoregulation;Immunosuppression;improved;Infection;Inflammatory;Infusion procedures;innovation;insight;irradiation;isoimmunity;Kidney;Knock-out;Life;Lung;lung allograft;lung basal segment;Lung Transplantation;Lymphoproliferative Disorders;Maintenance;Marrow;Monoclonal Antibodies;Mus;nonhuman primate;novel;novel strategies;Patient-Focused Outcomes;post-transplant;preservation;Protocols documentation;PTPRC gene;Public Health;Regimen;Regulation;Regulatory T-Lymphocyte;Research;Research Personnel;Resistance;Risk;Safety;Signal Transduction;Sirolimus;Specificity;Steroid Resistance;Steroids;success;synergism;T-Cell Activation;T-Lymphocyte;Testing;TNFSF4 gene;TNFSF5 gene;Toxic effect;Transplantation;Transplantation Tolerance;Treg therapy;Virus

PROJECT_TITLE: Project 2: The New Era of Cellular Therapies For Lung Transplant Tolerance


NIH_SPENDING_CATS: Cancer

PHR: PROJECT NARRATIVE Not applicable

PI_NAMEs: LAUBENTHAL, CHRISTOPHER K (contact)

PROJECT_TERMS: Advocate;Award;Cancer Center;Cancer Center Support Grant;Catchment Area;Clinical;Clinical Research;Collaborations;Communication;Communities;Complement;Comprehensive Cancer Center;Education;Educational Activities;Environment;Evaluation;Fostering;Funding;Future;Grant;Growth;Growth and Development function;Human Resources;Infrastructure;Iowa;Leadership;Malignant Neoplasms;meetings;member;Mission;NCI Center for Cancer Research;operation;Peer Review;Process;Research;Research Activity;research faculty;Research Priority;Research Support;Resources;Services;Strategic Planning;Universities;Work

PROJECT_TITLE: Administration Core


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Immunotherapy;Women's Health Research

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on optimizing the therapeutic potential of STING agonists for the treatment of triple negative breast cancer where there is a critical need. The major barrier to the clinical realization of STING agonists for solid malignancies is the transient nature of the drug in the tumor microenvironment, and as such we propose a multifaceted approach to better retain the drug by using a PEGylated breast biopsy marker system and by inhibiting cell intrinsic degradation through targeting Rab7 and TREX1. Thus, the proposed research is relevant to the part of the NIH's mission that pertains to fostering fundamental creative discoveries, innovative research strategies, and their applications as a basis for ultimately protecting and improving health.

PI_NAMEs: BARBIE, THANH UYEN (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: 4T1;Agonist;analog;anti-PD1 therapy;biomarker driven;Breast biopsy;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Prevention;breast malignancies;cancer cell;cancer immunotherapy;Cells;Clinical;clinical application;clinical translation;Clinical Trials;clinically actionable;Creativeness;cytokine;Cytoplasm;Data;Development;Dinucleoside Phosphates;Drug Delivery Systems;Drug Kinetics;Drug usage;ds-DNA;effective therapy;evidence base;exodeoxyribonuclease;Exonuclease;Extravasation;first-in-human;Fostering;Gene Activation;Gene Expression;gene function;Genetic;Goals;Growth;Health;Human;Hyperactivity;IKKepsilon;Immune signaling;Immunotherapy;Impairment;improved;in vivo;inhibitor;Injections;Innate Immune Response;innovation;insight;interest;Knock-out;Knowledge;Laboratory Study;Lysosomes;Malignant Neoplasms;Methods;Mission;Modeling;mouse model;Mus;Nature;neoplastic cell;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;Pathway interactions;Patients;Periodicity;Pharmaceutical Preparations;pharmacologic;Phase I Clinical Trials;Phosphotransferases;Polyethylene Glycols;Polymers;Precision therapeutics;prevent;Prognosis;PTEN gene;Public Health;RAS Superfamily Proteins;recruit;Reporting;Research;Research Personnel;response;Rodent;Role;Secondary to;Signal Transduction;Solid;Stimulator of Interferon Genes;STING1 gene;System;T-Lymphocyte;TBK1 gene;Testing;Therapeutic;therapeutic gene;Three Prime Repair Exonuclease 1;Tissues;Toxic effect;trafficking;Translations;Treatment Efficacy;treatment response;trend;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;tumor microenvironment;United States National Institutes of Health;Up-Regulation

PROJECT_TITLE: Optimizing Therapeutic STING Agonism in Triple Negative Breast Cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Natural Products;Neurosciences;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This project will determine the degree to which cannabis use alters antiretroviral therapy (ART) pharmacokinetics (PK) among persons living with HIV (PLWH). In particular, the study will focus on effects relating to blood-brain barrier (BBB) permeability, CSF PK, and ART efficacy and neurotoxicity. As a result of this project, we aim to further understand the factors that may affect the persisting presence of HIV-associated neurocognitive disorders (HAND).

PI_NAMEs: HENRY, BROOK ;LETENDRE, SCOTT L (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: ABCB1 gene;Acetaminophen;Acute;Address;Affect;age effect;Albumins;Anatomy;anti-viral efficacy;antiretroviral therapy;Biological;Biological Markers;Blood;Blood - brain barrier anatomy;blood-brain barrier permeabilization;Buspirone;Cannabidiol;Cannabinoids;Cannabis;cannabis administration;Categories;CD4 Positive T Lymphocytes;Cell Count;Central Nervous System;Cerebrospinal Fluid;Characteristics;Chronic;co-infection;Cognition;Cognition Disorders;Cognitive;comorbidity;Consequences of HIV;Cytochrome P450;cytochrome P450 3A;Data;design;Disease;DNA;Dose;Double-Blind Method;drug distribution;Drug Kinetics;Drug usage;eligible participant;Emotional;enzyme activity;Enzymes;exogenous cannabinoid;General Population;Glucuronosyltransferase;Health;HIV;HIV-associated neurocognitive disorder;Inflammation;Knowledge;Legal;Literature;marijuana use;Measures;Medical;Medical Marijuana;Medicine;Mental Depression;Metabolism;Molecular;Mood Disorders;Moods;neurobehavioral;neurobehavioral disorder;Neurocognitive;neurotoxicity;NIH Office of AIDS Research;Outcome;Participant;Pathogenesis;Pathway interactions;Pattern;Performance;Peripheral Blood Mononuclear Cell;Permeability;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetic model;Pharmacology;Placebos;Plasma;Play;programs;Randomized;Recreation;Research;Research Priority;Resources;RNA;Route;Serum Albumin;sex;Subgroup;substance use;Tetrahydrocannabinol;therapy adherence;Toxic effect;Treatment Efficacy;Treatment-related toxicity;Uridine;Visit

PROJECT_TITLE: Cannabis Effects on Antiretroviral Therapy, Pharmacokinetics, and Neurotoxicity

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health

PI_NAMEs: HOUTMAN, JON C.D. (contact)

PROJECT_TERMS: Advisory Committees;anti-cancer research;Cancer Biology;Cancer Center;Cancer Center Support Grant;career;Catchment Area;Collaborations;Communities;Comprehensive Cancer Center;design;Development;Doctor of Philosophy;Education;Educational Status;ethnic diversity;Faculty;faculty mentor;Fostering;Goals;Grant;High School Student;Household;Infrastructure;innovation;Institution;Iowa;Learning;Malignant Neoplasms;Mentors;Middle School Student;Mission;NCI Center for Cancer Research;programs;Provider;Research;Research Personnel;Resources;Rural Community;Rural Population;senior faculty;Series;Site;socioeconomics;summer research;symposium;Talents;Teenagers;Training;Training and Education;Training and Infrastructure;Training Programs;Training Support;Underrepresented Minority;Universities

PROJECT_TITLE: Career Enhancement


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Prevention;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This collaborative study between Johns Hopkins University, the Nigeria Centre for Disease Control, Makerere University, the Ugandan Ministry of Health and the University of Florida Emerging Pathogen Institute builds on the findings from our earlier RO1 study of the “Epidemiology and Ecology of Cholera in Africa” which concluded that cholera outbreaks result from the “spread” of genetic lineages rather than from strains “emerging from the environment” like it does in Bangladesh. It also builds on the innovative molecular and GIS technologies developed during the earlier grant period to support a detailed study of transmission of the genetic lineages. The project will assist countries identify and stop cholera transmission, leading to a “cholera elimination scorecard” by which countries can monitor progress toward national elimination.

PI_NAMEs: DEBES, AMANDA KAY;SACK, DAVID A (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Advisory Committees;Africa;African;Area;Bacteriophages;Bangladesh;Biological;Biological Assay;Border Crossings;Cameroon;Case Study;Centers for Disease Control and Prevention (U.S.);Cessation of life;Cholera;Climate;Clinical;Collaborations;Country;Detection;Developing Countries;Diagnostic tests;Disease;Disease Outbreaks;DNA;Dryness;Ecology;Effectiveness;emerging pathogen;Environment;Epidemiology;epidemiology study;Evaluation;Feces;Florida;Genetic;genome sequencing;Genotype;Goals;Grant;Health;Hygiene;Immunity;improved;innovation;Institution;Interruption;Intervention;Maps;Methods;Molecular;Molecular Epidemiology;Monitor;Movement;Mozambique;new technology;Nigeria;Oral;Paper;Patients;Pattern;Persons;Play;Predatory Behavior;Predisposition;prevent;prevent outbreaks;Public Health;rapid detection;Rapid diagnostics;Readiness;Recommendation;Refrigeration;Relapse;Reporting;repository;Residual state;Resources;response;Role;Route;Sampling;Sanitation;Seasons;Sewage;Spottings;stool sample;Technology;Time;transmission process;Uganda;Universities;Vaccines;Vibrio;Vibrio cholerae;Vibrio cholerae O1;Water;whole genome

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Clinical Research;Diabetes

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Narrative Diabetic complications, particularly impaired wound healing and diabetic nephropathy, represent a major unmet need. The RAGE/DIAPH1 pathway contributes importantly to diabetic complications. In this application, we will work to develop novel small molecule antagonists of this interaction to treat the complications of diabetes.

PI_NAMEs: RAMASAMY, RAVICHANDRAN ;SCHMIDT, ANN MARIE (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Address;Ames Assay;Amino Acids;analog;Aniline;Animals;antagonist;Anterior Descending Coronary Artery;Antibodies;Arterial Injury;Atherosclerosis;Attenuated;Benchmarking;Binding;Biological Assay;Biological Availability;Biophysics;candidate selection;Canis familiaris;Cardiac Myocytes;cell transformation;Cells;Chemistry;clinical development;Complications of Diabetes Mellitus;Coupled;Cultured Cells;Cytoplasmic Tail;Data;data modeling;Delayed Hypersensitivity;design;Development;Diabetes Mellitus;Diabetic mouse;Diabetic Nephropathy;Disease;Drug Design;drug discovery;Drug Interactions;Drug Kinetics;Endothelial Cells;Epithelial Cells;Evaluation;experimental study;extracellular;Extracellular Domain;Family suidae;Female;Foundations;Genes;Genetic;Goals;Grant;high throughput screening;Immunoglobulin Domain;Impaired wound healing;In Vitro;in vivo;in vivo Model;Indoles;Inflammation;Insulin-Dependent Diabetes Mellitus;Interdisciplinary Study;Kidney;Kidney Diseases;Laboratories;Lead;lead candidate;lead optimization;lead series;Left;Ligand Binding;Ligands;Ligation;Macrophage;macrovascular disease;male;Mediating;Medical;Metabolic Activation;Modeling;Modification;Morbidity - disease rate;mortality;multidisciplinary;Mus;Mutation;myocardial infarct sizing;Myocardial Ischemia;National Institute of Diabetes and Digestive and Kidney Diseases;NMR Spectroscopy;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Oral;Pathology;Pathway interactions;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Positioning Attribute;programs;Property;Proteins;rational design;Rattus;receptor for advanced glycation endproducts;Reperfusion Injury;Reperfusion Therapy;Research;research clinical testing;response;risk mitigation;Rodent;Safety;safety study;scaffold;screening;Selection Criteria;Series;Signal Induction;Signal Transduction;Site;small molecule;small molecule libraries;Smooth Muscle Myocytes;Specificity;Structure;Structure-Activity Relationship;Testing;Therapeutic;therapeutic evaluation;Tissues;Toxicity Tests;Treatment Efficacy;Validation;Work

PROJECT_TITLE: Targeting RAGE/DIAPH1: Novel Therapeutic Strategy for Diabetic Complications


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Rare Diseases;Women's Health Research

PI_NAMEs: QUELLE, DAWN E (contact)

PROJECT_TERMS: Achievement;Affect;Animals;Arsenic;Automobile Driving;B-Lymphocytes;Basic Science;Bioinformatics;Biological;Biological Models;Blood Cells;Breast Adenocarcinoma;Breast Cancer Cell;Budgets;cancer cell;Cancer Center Support Grant;cancer initiation;Cancer Patient;carcinogenicity;Cell Physiology;Cell Survival;cell transformation;Cells;Clinical Management;Clinical Research;Collaborations;college;Comprehensive Cancer Center;Development;DNA Repair;Drug resistance;Environment;Environmental Carcinogens;Epigenetic Process;Event;extracellular;Family suidae;Foundations;Funding;Genetic;Genetic Markers;genetic signature;Genome Stability;Genomic Instability;Genomics;Goals;Grant;GTP-Binding Proteins;Human;Immune;immune activation;Immunologics;improved;innovation;insight;Institution;inter-institutional;Investigation;Iowa;Journals;Knowledge;Leadership;Lung Adenocarcinoma;Lymphoma;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Manuscripts;mechanical force;Melanoma;member;metaplastic cell transformation;model development;Modeling;Molecular;Multiple Myeloma;Mus;Mutagenesis;Neoplasm Metastasis;Neuroendocrine Therapy;Neuroendocrine Tumors;new therapeutic target;novel;Nuclear;Oncogenes;Outcome;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Peer Review;Pharmaceutical Preparations;Process;Productivity;programs;prostate cancer cell;Proteins;Publications;RAD52 gene;Receptor Protein-Tyrosine Kinases;Research;Research Personnel;response;Role;Sarcoma;Signal Transduction;Signaling Protein;stemness;therapeutic target;Toxic Environmental Substances;translational cancer research;translational oncology;tumor;tumor initiation;tumor metabolism;tumor microenvironment;tumor progression;tumorigenesis;Tyrosine Kinase Inhibitor;Validation;Work;Zebrafish

PROJECT_TITLE: Cancer Genes and Pathways


ORG_CITY: LITTLE ROCK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Project Narrative The consequences of irradiation- and/or Cisplatin (IR/CisP)-induced neurotoxicity, often irreversible and permanent neurological deficits, represent a daunting challenge when treating patients with cancer. This proposal aims to determine the mechanisms protecting neurons from IR/CisP-induced cytotoxicity, with the overarching goal to provide evidence supporting novel strategies to decrease their neurotoxicity, while maintaining therapy efficacy and improving patient quality of life. We expect this study to lay the foundation for future research investigating the targeting of the CDK5/SIRT2-CSB signaling axis as a novel strategy to alleviate and/or prevent neurotoxicity in cancer patients who need IR/CisP therapy.

PI_NAMEs: XIA, FEN  (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Attenuated;Behavioral;Binding;Biological;biological adaptation to stress;cancer cell;Cancer Patient;cancer therapy;Cell Death Induction;Cell Differentiation process;Cell Nucleus;Cell Physiology;Cell Survival;Cells;Cisplatin;Clinic;Cockayne Syndrome;Coupled;Cyclin-Dependent Kinase 5;cytotoxicity;Data;Deacetylase;Deacetylation;DNA Damage;DNA Repair;experimental study;Foundations;Genetic;Genetic Transcription;Goals;homologous recombination;improved;In Vitro;in vivo;Induced Neurons;inhibitor;insight;Interruption;Ionizing radiation;irradiation;Lung Adenocarcinoma;Malignant Neoplasms;Maps;Mediating;Mediator;Metabolism;Modeling;Molecular;mouse model;neoplastic cell;Nervous System Physiology;Neurologic;Neurologic Deficit;Neuronal Differentiation;neuronal survival;Neurons;neurotoxicity;nicotinamide-beta-riboside;novel;novel strategies;Nuclear;Nucleotide Excision Repair;Oxidative Stress;Pathway interactions;Patients;Peripheral;Peripheral Nervous System Diseases;pharmacologic;Phase;Phosphorylation;prevent;Proliferating;Proteins;Quality of life;recombinational repair;recruit;repaired;Resistance;response;Role;roscovitine;Series;Serine;Signal Transduction;Sirtuins;Site;Spinal Ganglia;Testing;Toxic effect;transcription factor;Transcription-Coupled Repair;Transcriptional Regulation;Treatment Efficacy;Treatment Protocols;tumor;Tumor Suppression

PROJECT_TITLE: The novel role of Sirtuin 2 in regulation of transcription-associated DNA damage repair

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: SPRINGFIELD

ORG_NAME: BAYSTATE MEDICAL CENTER, INC.

PHR: PROJECT NARRATIVE Although smoking is the leading cause of premature non-communicable death in the United States and contributes to millions of hospitalizations annually, most hospitalized smokers are rarely prescribed any kind of smoking cessation medication to help them quit. In this project, we will employ a nurse practitioner-led, hospital-based tobacco treatment team to prescribe effective medications, counsel patients on how to use them properly, and manage a text messaging system with the goal to maximize medication use, adherence, and smoking cessation. We anticipate demonstrating the effectiveness, feasibility, acceptability, cost- effectiveness, and sustainability of this program, so that, in the future, more hospitals will be able to capture the “teachable moment” of hospitalization to help smokers quit permanently.

PI_NAMEs: PACK, QUINN RUSSELL (contact)

PROGRAM_OFFICER_NAME: EINHORN, PAULA T

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Administrator;American;Behavioral;Cardiopulmonary;Cause of Death;Cellular Phone;Cessation of life;Combination Medication;cost;cost effective;cost effectiveness;Cost Savings;Counseling;Coupled;Data;discount;economic evaluation;economic value;Economics;Effectiveness;effectiveness evaluation;effectiveness-implementation randomized trial;effectiveness/implementation trial;experience;Failure;Financial Hardship;Financial Support;follow-up;Future;General Hospitals;Goals;Grant;Guidelines;health economics;Health Expenditures;Hospital Administrators;Hospitalization;Hospitals;Hybrids;implementation outcomes;implementation science;implementation strategy;improved;Individual;Inhalators;Inpatients;Insurance;Intervention;Interview;Knowledge;Lead;Length of Stay;low socioeconomic status;Measures;Mediating;medication compliance;Medicine;member;Meta-Analysis;Modeling;Motivation;multidisciplinary;nicotine patch;Nicotinic Agents;Nurse Practitioners;Outpatients;Patients;Pharmaceutical Preparations;Pharmacotherapy;Physicians;Policies;premature;Proctor framework;Professional counselor;Program Sustainability;Pulmonary Heart Disease;Qualitative Methods;quitline;Randomized;randomized trial;Recommendation;Safety;Services;skills;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;smoking relapse;success;symptom management;System;Technology;tertiary care;Testing;Text Messaging;theories;Time;Tobacco;Tobacco use;Training;treatment and outcome;treatment as usual;treatment program;United States;uptake;varenicline;virtual;Wages

PROJECT_TITLE: Implementing Effective Smoking Cessation Pharmacotherapy for Hospitalized Smokers with Cardiopulmonary Disease

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Clinical Research;Genetics;Kidney Disease;Pediatric;Rare Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: NARRATIVE Steroid resistant nephrotic syndrome (SRNS) is a leading cause of chronic kidney disease in the first three decades of life1. Renal biopsies typically reveal focal segmental glomerulosclerosis (FSGS), and these children are unresponsive to standard steroid therapy and invariably progress to end-stage renal disease. This career development grant will explore the pathogenic mechanisms by which human mutations in the novel disease genes NOS1AP and TRIM8 cause SRNS/FSGS.

PI_NAMEs: MAJMUNDAR, AMAR J (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Actins;Adaptor Signaling Protein;Advisory Committees;Agreement;Albuminuria;Antibodies;Biological;Biology;Blood;Boston;career;career development;CDC42 gene;Cell Physiology;Cells;Central Nervous System;Child;Childhood;Chronic Kidney Failure;Co-Immunoprecipitations;Coupled;Creatinine;Critical Pathways;Cytoskeleton;Data;Dedications;Defect;Development Plans;Disease;disease model;Edema;Electron Microscopy;End stage renal failure;Ensure;Environment;Epilepsy;Exhibits;Family;Focal and Segmental Glomerulosclerosis;Foot Process;Functional disorder;Funding;Genes;Genetic;glomerulosclerosis;Grant;Growth;Guanine Nucleotide Exchange Factors;Hand;Human;Hypoalbuminemia;Immunofluorescence Immunologic;Immunoprecipitation;Impairment;innovation;Institution;Kidney;kidney biopsy;Kidney Failure;Kidney Glomerulus;Knock-in;Label;Laboratories;Life;light microscopy;liquid chromatography mass spectrometry;Mediating;medical schools;Medicine;meetings;Mentors;Methodology;Microscopy;migration;Modeling;mouse model;Mus;mutant;Mutate;Mutation;Nephrology;Nephrotic Syndrome;Nitric Oxide Synthase Type I;novel;Nuclear;Nucleoplasm;overexpression;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pediatric Hospitals;podocyte;Program Development;Proliferating;Proteins;Proteinuria;Proteomics;Publications;Research;research and development;Research Proposals;Research Support;Resistance;Role;Science;Serum;Serum Albumin;Services;Steroid therapy;Steroid-resistant idiopathic nephrotic syndrome;Structure;success;symposium;Training;Ubiquitin;ubiquitin-protein ligase;Urine;Vocational Guidance;Western Blotting

PROJECT_TITLE: Delineation of pathogenic mechanisms of NOS1AP and TRIM8 mutations in monogenic SRNS/FSGS.

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Data Science;Dementia;Genetic Testing;Genetics;Lewy Body Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative This proposal will use transcriptomic data from plasma to model a predictive tool for Alzheimer Disease using bioinformatics and machine learning approaches. This is an innovative approach, a cost-effective and minimally invasive biomarker for Alzheimer Disease, which is critical for early detection (preclinical), diagnosis, disease intervention and monitoring. If successful, the results will lead to a breakthrough in the field.

PI_NAMEs: IBANEZ, LAURA  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: abeta deposition;accurate diagnosis;African American;alpha synuclein;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease diagnostic;Alzheimer's disease model;Alzheimer’s disease biomarker;Amyloid beta-Protein;Amyloid deposition;anti-cancer research;Area;Autopsy;Award;Bioinformatics;bioinformatics tool;Biological;Biological Markers;blood-based biomarker;Brain;burden of illness;care costs;Cells;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Clinical;cohort;Complex;cost effective;cost effectiveness;Custom;Data;Data Discovery;Data Set;deep neural network;Dementia;Dementia with Lewy Bodies;Deposition;design;Diagnosis;diagnostic screening;Diagnostic tests;diagnostic tool;Differential Diagnosis;digital;Disease;Disease Progression;disease-causing mutation;disorder control;Early Diagnosis;Economic Burden;feature selection;Fetal Development;Forensic Medicine;Genes;Goals;High-Throughput Nucleotide Sequencing;Human;Imaging Techniques;improved;Individual;Informatics;innovation;insight;Intervention;Knowledge;Learning Skill;longitudinal dataset;Machine Learning;Malignant Neoplasms;Medical Care Costs;Mentors;Methods;minimally invasive;Modeling;Monitor;mutation carrier;nano-string;Nerve Degeneration;Neurodegenerative Disorders;neuropathology;novel diagnostics;novel marker;Nucleic Acids;Nucleotides;Outcome;Parkinson Disease;Participant;Pathogenesis;Pathologic;Pathway interactions;Patients;Phase;Plasma;Plasma Cells;pre-clinical;predictive modeling;predictive tools;prenatal testing;presenilin-1;presenilin-2;prognostic tool;Reagent;Research Design;RNA;ROC Curve;Sampling;Screening procedure;skills;Specificity;Study Subject;Symptoms;Techniques;Testing;therapeutically effective;Time;tool;Training;trait;Transcript;transcriptome;transcriptome sequencing;transcriptomics;treatment response

PROJECT_TITLE: Plasma Cell-Free RNA as Non-invasive Biomarker for Neurodegeneration

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Immunotherapy;Precision Medicine

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE  Colorectal cancer is one of the most prevalent malignancies and a deadly form of cancer. Colorectal tumors at advanced stages often progress after initial treatment and become resistant to current therapies. The proposed studies will develop a new class of anticancer agents for targeting proteins that are essential for colorectal cancer cell growth and survival. In the long run, these studies may lead to new and improved therapies against colorectal cancer and other types of cancer.

PI_NAMEs: ZHANG, LIN  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;anti-tumor immune response;anticancer activity;Antineoplastic Agents;Apoptosis;Apoptotic;Biological Assay;Biological Markers;Bromodomain;Bromodomains and extra-terminal domain inhibitor;c-myc Genes;cancer cell;Cancer Cell Growth;Cancer Etiology;cancer initiation;Cancer Patient;cancer type;Carcinoma;Cell Death;cell killing;Cell Proliferation;Cell Survival;Cells;Cessation of life;Chemosensitization;chemotherapy;colon cancer patients;Colorectal Cancer;colorectal cancer treatment;Colorectal Neoplasms;CT26;Data;DNA;driver mutation;effective therapy;endoplasmic reticulum stress;Epigenetic Process;Exhibits;Genetic Transcription;Histone Acetylation;Immune;immunogenic;immunogenic cell death;Immunotherapy;improved;insight;Malignant Neoplasms;Mediating;metastatic colorectal;Metastatic Neoplasm to the Liver;Mismatch Repair;Modeling;Molecular;mortality;Mus;Mutation;novel;Oncogenic;Pathway interactions;patient derived xenograft model;personalized medicine;pre-clinical;Precision therapeutics;predictive marker;Protein Family;Proteins;Reader;Refractory;research clinical testing;Resistance;small molecule;small molecule inhibitor;targeted agent;targeted treatment;Tertiary Protein Structure;Testing;Therapeutic;TNFRSF10B gene;Treatment Efficacy;tumor;Tumor Immunity;tumor progression;Tumor Suppression;tumor xenograft;ubiquitin-protein ligase

PROJECT_TITLE: BET degraders for improving colorectal cancer therapy


NIH_SPENDING_CATS: Bioengineering;Cancer;Nanotechnology;Orphan Drug;Rare Diseases;Uterine Cancer;Women's Health Research

PHR: PROJECT NARRATIVE  Not applicable

PI_NAMEs: WENDT, MICHAEL KEITH (contact)

PROJECT_TERMS: Acceleration;Achievement;Agonist;Basic Science;bench to bedside;Budgets;cancer cell;Cancer Center Support Grant;cancer immunotherapy;Chemotherapy and/or radiation;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;college;Comprehensive Cancer Center;Dedications;Development;Direct Costs;DNA Repair;drug development;Endometrial Carcinoma;Ewings sarcoma;Funding;Funding Mechanisms;Goals;high throughput screening;innovation;Institution;inter-institutional;Investigational Therapies;Journals;Laboratories;Malignant Neoplasms;Manuscripts;member;Molecular Target;Monitor;Multiple Myeloma;nanoparticle;new therapeutic target;novel;novel therapeutic intervention;Peer Review;Pharmacologic Ascorbate;Phase;Phenotype;preclinical evaluation;Private Sector;Productivity;programs;Publications;Radiation therapy;Research;Research Personnel;Research Project Grants;response;Scientist;synthetic lethal interaction;Testing;Therapeutic;Toll-like receptors;Toxic effect;Toxicity due to chemotherapy;Translating;translational cancer research;Translational Research;translational scientist

PROJECT_TITLE: Experimental Therapeutics


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Natural Products;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_DEPT: CHEMISTRY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: NARRATIVE Chemistry and Pharmacology of Iboga Alkaloids There is an urgent need for the development of novel therapeutics for substance use disorders (SUDs). Ibogaine, the major psychoactive alkaloid of the African plant Tabernanthe iboga, represents an important prototype for this purpose. We propose to create and systematically examine novel ibogaine analogs in terms of synthetic methods and pharmacology, and provide new pharmacological probes for research relevant to SUDs and related psychiatric disorders.

PI_NAMEs: SAMES, DALIBOR  (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Absence of pain sensation;Abstinence;Address;Advanced Development;Adverse effects;Africa;African;Alcohols;Alkaloids;Alkenes;Amines;Analgesics;analog;Animals;ARRB2;attenuation;Behavior;Behavioral;Benzofurans;benzothiophene;Biological;Biological Assay;Bioluminescence;Biophysics;C10;carbene;Cardiac;Cell Line;Central Africa;Chemistry;Clinical;clinical effect;Clinical Research;Clinical Trials;Cocaine;Coupling;craving;Data;depressive symptoms;design;Development;Diels Alder reaction;disease model;Dissociation;Docking;Drug Addiction;drug craving;Drug Kinetics;drug metabolism;drug of abuse;Drug usage;efficacy evaluation;enantiomer;Energy Transfer;Engineering;Epidemic;Europe;Exhibits;experience;experimental study;G Protein-Coupled Receptor Signaling;Goals;GTP-Binding Proteins;healing;Human;Hydrogen Bonding;Iboga;Ibogaine;In Vitro;in vivo;Indoles;insight;Interruption;Ion Channel;kappa opioid receptors;Laboratories;Lead;Ligands;Light;Maps;Mental disorders;Methadone;Methods;Modeling;Molecular Target;monoamine;Morphine;morphine administration;Mus;Naloxone;Native-Born;neurobehavioral;Neuropharmacology;new chemical entity;Nickel;Nicotine;Nicotinic Receptors;novel;novel therapeutics;open label;Opiate Addiction;Opioid;Opioid agonist;Opioid Receptor;opioid use disorder;opioid withdrawal;Organic Synthesis;Overdose;overdose death;Oxygen;Parents;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenols;Plants;Positioning Attribute;pre-clinical;Property;prototype;Rattus;Reaction;receptor;Receptor Signaling;Relapse;Replacement Therapy;Reporting;Research;response;Rodent;Rodent Model;Role;scaffold;Sedation procedure;sedative;Self Administration;Series;side effect;Signal Transduction;Skeleton;substance use;Substance Use Disorder;substance use treatment;Sulfur;Synthesis Chemistry;System;Tail;tertiary amine;Testing;Validation;Withdrawal;Withdrawal Symptom

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PHS Relevance Statement Colorectal cancer (CRC) prevails as the third most common and deadliest cancer worldwide, affecting both men and women. Despite scientific breakthroughs, gaps in knowledge remain due to the multiple accumulation of molecular alterations occurring at onset and during disease progression. This study will investigate the role of the transcription factor STAT2 as a signaling mediator in the communication exchange between cancer cells and fibroblasts in the tumor microenvironment to accelerate disease progression.

PI_NAMEs: GAMERO, ANA M (contact)

PROGRAM_OFFICER_NAME: GEORGE, CHRISTINA DAWN

PROJECT_TERMS: Acceleration;Address;Affect;Animal Model;antitumor effect;Applications Grants;Biological;Biopsy;cancer biomarkers;cancer cell;cancer recurrence;Cancer Relapse;cancer therapy;Cell Communication;Cell Extracts;Cells;Chemicals;chemotherapy;Clinical;clinically relevant;Coculture Techniques;Colon;colon cancer patients;colon carcinogenesis;Colon Carcinoma;colon tumorigenesis;Colorectal Cancer;Communication;Computer Analysis;Conditioned Culture Media;CRISPR/Cas technology;Data;Data Set;Development;Disease;Disease Progression;EGF gene;Enabling Factors;Epidermal Growth Factor Receptor;Exposure to;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Gene Expression;Gene Expression Profile;Genes;Growth;Human;In Vitro;in vivo;Incidence;Incubated;intercellular communication;Interferon Type I;Invaded;Investigation;Knowledge;Malignant Neoplasms;MAP Kinase Gene;Measures;Mediating;Mediator;men;metastatic colorectal;migration;Molecular;mortality;multiplex assay;Neoplasm Metastasis;neoplastic cell;NF-kappa B;novel therapeutic intervention;Oncogenic;Phenotype;phenotypic biomarker;PIK3CG gene;Platelet-Derived Growth Factor;Play;prognostic indicator;programs;Proliferating;Proteins;Resistance;Role;Signal Pathway;Signal Transduction;STAT2 gene;Stat2 protein;STAT3 gene;Stromal Cells;success;System;targeted treatment;The Cancer Genome Atlas;Therapeutic Intervention;TNF gene;transcription factor;transcriptome sequencing;Transforming Growth Factor beta;tumor;Tumor Burden;Tumor Cell Invasion;tumor growth;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;tumorigenic;Tumorigenicity;Woman

PROJECT_TITLE: Investigation of STAT2 Signaling in the tumor microenvironment


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease

PI_NAMEs: SPITZ, DOUGLAS ROBERT (contact)

PROJECT_TERMS: Adjuvant;Algorithms;anti-cancer research;Biochemical;Biochemistry;Biological Markers;biomarker development;Cancer Biology;cancer cell;Cancer Center Support Grant;Cancer Diagnostics;cancer therapy;Chronic;college;Cytotoxic Chemotherapy;Development;Discipline;Epigenetic Process;Free Radicals;Functional Imaging;Funding;Genetic;Head and Neck Cancer;Image;image guided;imaging platform;imaging program;Imaging Techniques;Imaging technology;improved;Institution;inter-institutional;Journals;Malignant Neoplasms;Measures;Medical Imaging;member;Metabolic;metabolic imaging;Metabolism;mimetics;Monitor;neoplastic cell;Neuroendocrine Tumors;Normal Cell;Normal tissue morphology;novel;oral mucositis;oxidation;Oxidation-Reduction;Oxidative Stress;Patient-Focused Outcomes;Peer Review;Peptides;Pharmacologic Ascorbate;Phase III Clinical Trials;Productivity;prognostic tool;programs;Publications;Radio;Radioisotopes;Reaction;Research;Research Personnel;Science;Signal Transduction;Superoxide Dismutase;Testing;theranostics;Therapeutic;Therapeutic Intervention;therapeutic target;therapy outcome;tissue injury;Tissues;Toxic effect;translational study;tumor;Tumor Biology;tumor metabolism;Work

PROJECT_TITLE: Free Radical Metabolism and Imaging


NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project narrative Expert statistical analysis is fundamental to generating high-quality research that ultimately informs evidence-based practices used to combat HIV in sub-Saharan Africa. This proposal responds to the acute need for building statistical and data analytic capacity for HIV research in Kenya and sub-Saharan Africa by laying the groundwork for a university program suitable for training the next generation of experts in HIV data science.

PI_NAMEs: HOGAN, JOSEPH W (contact);MWANGI, ANN

PROJECT_TERMS: Africa South of the Sahara;African;Agriculture;Biometry;Biostatistical Methods;Canada;college;Data Science;design;Development;Doctor of Philosophy;Education;Educational Curriculum;Educational Status;Educational workshop;Europe;experience;Faculty;Fellowship;Foundations;Funding;Geography;Growth;Health;health data;Health Sciences;HIV;Infrastructure;Institution;International;Kenya;member;Methods;Nature;peer;Phase;Physicians;post-doctoral training;Process;programs;Research;Science;Scientist;statistics;Students;Teacher Professional Development;Training;Training Programs;United States;Universities;Work

PROJECT_TITLE: Brown Moi Partnership for Biostatistics Training in HIV-NAMBARI


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Health Services;Hematology;Immunization;Infectious Diseases;Lung;Lung Cancer;Lymphatic Research;Lymphoma;Ovarian Cancer;Prevention;Primary Health Care;Rare Diseases;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Tobacco;Tobacco Smoke and Health;Vaccine Related;Women's Health Research

PI_NAMEs: CHARLTON, MARY E. (contact)

PROJECT_TERMS: Address;Adolescent and Young Adult;Awareness;Behavioral;biobehavior;breast cancer survival;Budgets;Cancer Burden;Cancer Center Support Grant;cancer epidemiology;Cancer Etiology;cancer prevention;cancer therapy;carcinogenicity;care outcomes;Catchment Area;Chronic Lymphocytic Leukemia;Clinical;Collaborations;college;Colorectal Cancer;colorectal cancer screening;Comprehensive Cancer Center;Contralateral Breast;Death Rate;Decision Making;diphenyl;end of life;Etiology;Funding;Genetic;Goals;Guidelines;Head and Neck Cancer;health care service;Health Services;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;improved;Incidence;Influentials;Institution;inter-institutional;interest;Intervention;Iowa;Journals;Knowledge;leukemia;Life Style;lung cancer screening;Lymphoma;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Melanoma;member;Morbidity - disease rate;mortality;multiple chronic conditions;Neuroendocrine Tumors;Obesity;Outcome;Patterns of Care;Peer Review;Pesticides;Polychlorinated Biphenyls;Population Research;Population Sciences;Primary Cancer Prevention;Productivity;Prognostic Factor;programs;Publications;quality of life for cancer survivors;Radon;Recommendation;Research;Research Peer Review;Risk Factors;Rural Population;rurality;Sarcoma;Science;screening;Screening for cancer;Secondary Cancer Prevention;Statutes and Laws;Stress;Tobacco use;Tobacco Use Cessation;Tumor Biology;United States Preventative Services Task Force;Vaccination

PROJECT_TITLE: Cancer Epidemiology and Population Science


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE New perinatal HIV infections continue and an estimated 1.7 million children are living with HIV. The goal of our research program is to address the limited understanding of how the host environment and immune system influences HIV reservoir establishment and maintenance in children. Our critical focus on virus-host interactions, with experiments designed to perturb these interactions in a preclinical model, will inform pediatric-specific approaches to cure perinatal HIV.

PI_NAMEs: CHAHROUDI, ANN M (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adaptive Immune System;Address;Adolescence;Anti-viral Response;antiretroviral therapy;Binding;Bioinformatics;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Child;Childhood;clinical trial protocol;cohort;Collaborations;Communication;Complex;curative treatments;Data;Development;Disease;efficacy evaluation;Environment;experience;Experimental Designs;experimental study;Future;Goals;high dimensionality;HIV;HIV Infections;Immune;immune function;Immune system;Immune System Diseases;Immunity;Immunology;immunoregulation;In Vitro;in vivo;Infection;Innate Immune System;insight;Integration Host Factors;Interleukin-10;Investigation;Knowledge;Link;Maintenance;medical schools;Mentors;Metabolic;microbial;Mission;Modeling;Morbidity - disease rate;mortality;multidisciplinary;multiple omics;Nature;Neonatal;novel;novel therapeutics;Output;pathogen;Pathology;Pathway interactions;pediatric department;pediatric human immunodeficiency virus;perinatal HIV;Perinatal Infection;perinatal period;Pre-Clinical Model;pressure;Primates;programs;Research;Research Personnel;Resources;Role;Scientist;single cell technology;SIV;synergism;System;Testing;Thymus Gland;Tissues;tool development;Transforming Growth Factor beta;United States National Institutes of Health;viral rebound;Viremia;Virus;virus host interaction;Virus Latency

PROJECT_TITLE: Immune determinants of pediatric HIV/SIV reservoir establishment and maintenance


NIH_SPENDING_CATS: HIV/AIDS;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric - AIDS

PROJECT_TERMS: Accountability;Accounting;Achievement;Acquired Immunodeficiency Syndrome;Adherence;Administrative Personnel;Advisory Committees;Animals;Annual Reports;Area;biobank;Bioinformatics;cloud based;Cloud Computing;Collaborations;Communication;Communities;Computer software;Data;data communication;data dissemination;data management;data sharing;Decision Making;Dedications;Documentation;Ensure;Environment;Feedback;Fostering;Funding;Funding Opportunities;Future;Goals;Guidelines;HIV-1;Immune;Infection;Infrastructure;Institution;Lead;Leadership;Maintenance;Manuscripts;meetings;Mentors;Monitor;Occupational activity of managing finances;Output;pediatric human immunodeficiency virus;Play;Policies;Preparation;Production;programs;Protocols documentation;Recording of previous events;Regulation;Reporting;repository;Research;Research Personnel;Research Project Grants;Research Support;Resource Allocation;Resource Sharing;Resources;Role;Sampling;Schedule;Services;Site;SIV;Specimen;Strategic Planning;Structure;symposium;synergism;System;United States National Institutes of Health;Universities;Update;Work


ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Affecting tens of millions of individuals in the United States alone, age-related high frequency hearing loss results in difficulty understanding speech and problems hearing environmental sound. Due to limitations in high frequency bone conduction testing, clinicians have assumed that presbycusis is due to sensorineural dysfunction, but emerging evidence suggests conductive pathology contributes to presbycusis. Our goal is to define the structural and functional consequences of aging on the ossicular chain and to develop non-invasive methods to identify and localize conductive presbycusis in humans.

PI_NAMEs: REMENSCHNEIDER, AARON KYLE (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Acceleration;accurate diagnostics;Acoustics;Affect;Age;age effect;age related;Aging;Air;Behavioral;Biological Assay;bone;Bone Conduction;Cadaver;Clinical;clinically relevant;Conductive hearing loss;cost;Development;Diagnosis;Ensure;Etiology;experience;Frequencies;Functional disorder;Goals;Hearing;hearing impairment;Hearing problem;Hearing Tests;High-Frequency Hearing Loss;Human;Impairment;Individual;ineffective therapies;interest;Investigation;Joints;Knowledge;Lasers;Lesion;Life;Light;Measurement;Mechanics;Methods;middle ear;novel;novel therapeutics;Operative Surgical Procedures;Otologic Surgical Procedures;Output;Pathology;patient subsets;Patients;Population;Postoperative Period;Presbycusis;Prevalence;repaired;Research;research clinical testing;Risk;Role;Secondary to;simulation;Social isolation;sound;sound frequency;Sound Localization;Source;source localization;Speech;Speech Sound;Stimulus;targeted treatment;Temporal bone structure;Testing;Transducers;transmission process;trend;United States;Work

PROJECT_TITLE: Mechanisms of Conductive Presbycusis in Humans

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric - AIDS

PI_NAMEs: SHARMA, ASHISH ARUNKUMAR (contact)

PROJECT_TERMS: Adolescence;Animals;Big Data;Binding;Bioinformatics;bioinformatics pipeline;Biological Assay;Biological Models;Biometry;Blood;Cells;Child;Childhood;Clinical;cohort;curative treatments;cytokine;Data;Data Analyses;data integration;data management;Data Set;data tools;Disease;Ensure;Environment;epigenome;Equipment and supply inventories;experimental study;Flow Cytometry;Future;Goals;high dimensionality;HIV;Human;Human Resources;Immune;Immune response;Immunologics;Individual;Information Technology;Infrastructure;insight;integration site;Interruption;Life;Machine Learning;Maintenance;member;Meta-Analysis;Metabolic;metabolomics;Metadata;Methodology;model building;Modeling;Molecular;multidimensional data;Multiomic Data;multiple omics;network models;Network-based;nonhuman primate;novel therapeutics;Outcome;Participant;Pathway interactions;pediatric human immunodeficiency virus;Plasma;Positioning Attribute;Pre-Clinical Model;predicting response;predictive modeling;Process;programs;Protocols documentation;Proviruses;Quality Control;Reporting;Research;Research Personnel;Research Support;Sampling;Secure;single cell sequencing;single cell technology;SIV;Specimen;Standardization;Structure;System;Testing;Therapeutic Intervention;therapeutic target;Tissues;tool development;transcriptome;Universities;Validation;Vertebral column;Viral Load result;viral rebound;Viral reservoir;Virus;virus host interaction


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: ASKELSON, NATOSHIA M. (contact)

PROJECT_TERMS: Address;Agrochemicals;Cancer Burden;Cancer Center Support Grant;Cancer Control;cancer health disparity;cancer prevention;Cancer Prevention Intervention;cancer research center director;Cancer Research Network;cancer risk;cancer therapy;care delivery;Caring;Catchment Area;Colorectal;Communication;Communities;community advisory board;Community Developments;community engaged research;community engagement;Community Health;Community Outreach;Comprehensive Cancer Center;Consultations;Data;Dedications;Dissemination and Implementation;Doctor of Philosophy;Environmental Exposure;ethnic disparity;Evaluation;evidence base;Evidence based intervention;Exposure to;Goals;Grant;Guidelines;health disparity;Human Papilloma Virus-Related Malignant Neoplasm;Incidence;Iowa;Iowan;Joints;Kidney;leukemia;Link;Logic;Lymphoma;Malignant Neoplasms;Melanoma;member;Minority Groups;Modeling;Monitor;mortality;NCI Center for Cancer Research;Needs Assessment;Obesity associated cancer;operation;Outcome;Pancreas;Persons;Policies;Population;Population Sciences;programs;racial disparity;Radon;Research;Research Personnel;Research Project Grants;Risk;Risk Factors;Rural;screening;Screening for cancer;sociodemographic disparity;Strategic Planning;Structure;Time;Training;Underrepresented Populations;Underserved Population;Visualization

PROJECT_TITLE: Community Outreach and Engagement


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: Project Narrative This proposal aims to decipher how a conserved retinal interneuron detects visual threats, generates divergent threat representations downstream, and how these representations guide innate defensive behaviors. Insights into the organization and function of visual pathways in health, facilitate identification of early disorganization and dysfunction in common diseases of the retina and the brain. In addition, knowledge about the function of specific pathways in visually guided behaviors establishes benchmarks for comparisons of competing strategies for vision restoration.

PI_NAMEs: KERSCHENSTEINER, DANIEL  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Amacrine Cells;Animals;Award;Axon;Behavior;Behavioral Assay;behavioral response;Benchmarking;Brain;Calcium;Categories;Cell Physiology;Cell Shape;cell type;Communication;Computer Models;Data;Dendrites;Diameter;Early identification;electric impedance;Electron Microscopy;Environment;experimental study;follow-up;Freezing;Functional disorder;ganglion cell;genetic manipulation;Glutamates;Glycine;Goals;Grant;Health;Human;Image;impression;Insecta;insight;Interneurons;Knowledge;Link;Mediating;Methods;Morphology;Mus;neural;Neurons;Neurosciences;Neurotransmitters;optogenetics;Output;Pathway interactions;Resolution;response;Response Generalization;Retina;Retinal Diseases;Retinal Ganglion Cells;Sensory;sight restoration;Signal Transduction;SLC17A8 gene;Stimulus;superior colliculus Corpora quadrigemina;Synapses;synaptic inhibition;System;Techniques;Testing;Tissues;transmission process;two-photon;Vesicle;Vision;Visual;Visual Pathways;visual processing

PROJECT_TITLE: Synaptic Organization and Function of Retinal Interneurons and Downstream Visual Pathways


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Food Allergies;Health Services

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Eosinophilic esophagitis (EoE) is an understudied chronic inflammatory disease with increasing prevalence, incidence, healthcare costs, and burdens to quality of life. As clinical equipoise exists between effective medication and dietary therapies, complex decision making around treatments and chronic disease management is challenging for patients and providers, and understanding the drivers of decision making and applying shared decision making are critical gaps in patient-centered EoE care. This proposal aims to leverage patient and provider experiences and preferences to develop and test a multilevel decision support intervention that will help patients with EoE and their physicians share information to support informed decision making in selecting treatments.

PI_NAMEs: CHANG, JOY WEILING (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: acceptability and feasibility;Achievement;Address;Adherence;Allergic;Area;Attitude;Automobile Driving;Book Chapters;career;career development;Caring;Chronic;Chronic Disease;chronic inflammatory disease;Clinic;Clinical;Collaborations;Communication;Complex;Conduct Clinical Trials;cost;Counseling;Data;Decision Making;Deglutition Disorders;design;Development;Development Plans;Diagnosis;Diet therapy;dietary;Disease;Disease Management;Disease Outcome;disorder control;Education;Educational workshop;efficacy outcomes;Ensure;Eosinophilic Esophagitis;Eosinophilic Gastrointestinal Disease;eosinophilic inflammation;Equipoise;Esophageal Diseases;Esophagus;Evaluation;Exclusion;experience;Face;Feedback;Fibrosis;Focus Groups;Food;Fostering;Functional disorder;Funding;Gastroenterologist;Gastroenterology;Goals;Grant;Guidelines;Health Care Costs;Health Personnel;health related quality of life;Healthcare;Immune;Impaired health;improved;Incidence;Individual;individual patient;individualized medicine;innovation;instructor;Intervention;Intervention Studies;Interview;Joints;Knowledge;Left;Literature;Manuscripts;Maryland;Mediating;meetings;Mentors;Mentorship;Methodology;Methods;Michigan;novel strategies;Outcome;patient engagement;patient oriented;Patient Outcomes Assessments;Patient Preferences;patient-clinician communication;Patients;Pattern;Peer Review;Pharmaceutical Preparations;Physicians;pilot test;preference;Prevalence;prevent;prototype;Provider;provider factors;Publishing;Qualitative Research;Quality of Care;Quality of life;Randomized;Readiness;Recommendation;Reporting;Research;Research Methodology;Research Personnel;response;satisfaction;Science;Scientist;shared decision making;Standardization;Structure;Symptoms;Testing;Training;treatment adherence;treatment as usual;treatment choice;Treatment Protocols;Universities;usability;Variant;web based decision aid;young adult

PROJECT_TITLE: Developing Patient-Centered Decision Support for Eosinophilic Esophagitis

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: HIV/AIDS;Immunotherapy;Infectious Diseases;Pediatric;Pediatric - AIDS

PROJECT_TERMS: Address;Adolescence;Adult;Anti-Inflammatory Agents;Antigen Presentation;antiretroviral therapy;antiviral immunity;Binding;biobank;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Proliferation;Cells;Child;Childhood;clinical trial protocol;Complex;cytokine;Data;effector T cell;efficacy evaluation;Emigrant;Environment;Event;genetic signature;HIV;HIV Infections;IL10 gene;Immune;immune function;Immune response;Immune system;Immune System Diseases;Immunity;Immunology;immunoregulation;Immunosuppression;Impairment;improved;in vivo;Infant;infant infection;Infection;Inflammatory;interdisciplinary approach;Interleukin-10;Interruption;Knowledge;Lead;Life;lymph nodes;Macaca;Macaca mulatta;Maintenance;Mediating;memory CD4 T lymphocyte;microbial;Mission;Modeling;Monoclonal Antibodies;Morbidity - disease rate;mortality;multiple omics;Nature;Neonatal;neonatal immune system;neonatal period;novel;Output;pathogen;Pathway interactions;pediatric human immunodeficiency virus;perinatal HIV;perinatal period;Plasma;pressure;programs;Regulatory T-Lymphocyte;Research;Research Personnel;Role;Sampling;Signal Pathway;Signal Transduction;simian human immunodeficiency virus;SIV;stemness;Stimulus;synergism;System;T cell response;Testing;TGF Beta Signaling Pathway;Thymus Gland;Time;Transforming Growth Factor beta;Viral;viral rebound;Viral reservoir;Viremia;Virus


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Experiments in this proposal center on congenital Neurocutaneous melanocytosis (NCM) that comprises a spectrum of neoplastic abnormalities involving pigment cells in the brain and skin, for which we know little about the origin, underlying genetics and developmental biology. We focus on the oncogene NRAS Q61K which has recently been shown to be a driver in human NCM patients and aim to decipher the mechanisms underlying the cellular and molecular etiology of the disease.

PI_NAMEs: BASU, DIPANJAN  (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: Address;Alleles;Automobile Driving;base;Benign;Biochemical;Birth;Brain;Cell Proliferation;cell transformation;cell type;Cells;Cessation of life;Congenital Disorders;CRISPR/Cas technology;Crossbreeding;Data;Detection;Development;Developmental Biology;Diagnosis;Diffuse;Disease;Embryo;embryo cell;Embryonic Development;Etiology;Experimental Models;experimental study;Exposure to;Fluorescence;fluorescence imaging;Future;Gene Expression;Gene Expression Profiling;Genetic;genetic variant;Global Change;Growth Factor;Growth Factor Overexpression;HGF gene;Histologic;Human;Hydrocephalus;Hyperplasia;Imaging Techniques;Immunohistochemistry;In Vitro;in vivo;in vivo imaging system;Inbred C57BL Mice;Incidence;Infiltration;Interleukin-2;Intracranial Hypertension;Knock-in;Knowledge;KRAS oncogenesis;Laboratories;Leptomeninges;Lesion;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Childhood Neoplasm;melanocyte;Melanocytic nevus;MET gene;Methods;Mission;Mitogen-Activated Protein Kinases;Mitogens;Molecular;Morphogenesis;mouse model;Mus;mutant;Mutation;neoplastic;neoplastic cell;Neoplastic Cell Transformation;Neural Crest;Neural Crest Cell;Neuroepithelial, Perineurial, and Schwann Cell Neoplasm;Neurologic;Neurologic Symptoms;novel;offspring;Oncogene Activation;Oncogenes;Oncogenic;overexpression;Pathogenesis;Pathway Analysis;Pathway interactions;Patients;Pattern;permissiveness;Physiological;Pigments;Play;pre-clinical;Pre-Clinical Model;Process;Prognosis;Property;rare cancer;Receptor Protein-Tyrosine Kinases;Reporting;response;Role;Sampling;Seizures;Signal Pathway;Signal Transduction;Skin;Sorting;spatiotemporal;stemness;Structure;Testing;Tissue-Specific Gene Expression;Tissues;transcriptome sequencing;transcriptomics;Transgenes;Transgenic Mice;Transgenic Organisms;tumor;tumorigenesis;tumorigenic;United States National Institutes of Health;Vertebrates

PROJECT_TITLE: To study the molecular oncogenesis of congenital Neurocutaneous melanocytosis in a preclinical transgenic mouse model


ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Program Director/Principal Investigator (Robey, Ellen, A): Narrative: The non-classical MHC-1 molecules MHC-E play key, but poorly understood, functions in immune protection and immune regulation. We propose to investigate the factors that determine the function of the mouse MHC- E molecule, Qa-1 in homeostasis and during viral infection. OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page

PI_NAMEs: COSCOY, LAURENT ;ROBEY, ELLEN A (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Affinity;Age;Agonist;Aminopeptidase;Antigen Presentation;Antigen Presentation Pathway;antigen processing;Automobile Driving;Binding;CD8-Positive T-Lymphocytes;CD94 Antigen;cell transformation;cell type;Cells;Characteristics;cooking;cross reactivity;Cytomegalovirus;Cytotoxic T-Lymphocytes;Data;Down-Regulation;Family;Generations;Germ Lines;Goals;HIV vaccine;Homeostasis;Homologous Gene;Human;Immune;Immune Evasion;immunoregulation;In Vitro;in vivo;Infection;insight;interest;KLRD1 gene;Ligands;Macaca;Mediating;member;Modeling;Mouse Strains;Mus;Natural Killer Cells;pathogen;Peptide Leader Sequences;Peptide/MHC Complex;Peptides;Phenotype;Play;Positioning Attribute;Principal Investigator;programs;Proteins;Qa-1 Antigen;receptor;response;Role;Signal Transduction;SIV Vaccines;Splenocyte;Stress;Structure of thymic cortex;Structure of thymic medulla;T cell response;T-Lymphocyte;Techniques;Testing;Thymus Gland;Tissues;Transgenic Mice;Tumor Immunity;Up-Regulation;Vaccine Design;Vaccines;vector;Viral;Virus Diseases;Wild Type Mouse

PROJECT_TITLE: Presentation of Qa-1 restricted peptides during homeostasis and viral infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-J(03)]


NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_NAME: UNIVERSITY OF IOWA

PHR: PROJECT NARRATIVE Not applicable

PI_NAMEs: BURKARD, MARK E (contact)

PROJECT_TERMS: Address;anti-cancer research;Area;Award;Basic Science;Cancer Center;Cancer Center Support Grant;career;Catchment Area;Clinic;Collaborations;Comprehensive Cancer Center;Development;DNA Repair;Doctor of Philosophy;Faculty;Faculty Recruitment;Funding;Goals;Grant;high risk;high throughput screening;innovation;Institution;Lead;Leadership;Malignant Neoplasms;Memory;Mission;Names;NCI Center for Cancer Research;Play;programs;recruit;Research;Research Personnel;Resources;Role;Science;Scientist;Strategic Planning;Translating;Work

PROJECT_TITLE: Developmental Funds


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;HIV/AIDS;Infectious Diseases;Osteoporosis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: AUGUSTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Frailty is frequently observed in HIV patients on long term antiretroviral therapy (ART), and both osteoporosis and sarcopenia are now recognized as co-morbidities among older people with HIV. This project will determine whether inhibiting a key pathway in muscle and bone, the aryl hydrocarbon receptor signaling pathway, can improve muscle and bone function with aging in older people living with HIV.

PI_NAMEs: BELIN DE CHANTEMELE, ERIC J;MCGEE-LAWRENCE, MEGHAN E. (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Acceleration;Address;Age;Age Months;Age-Related Bone Loss;aged;Aging;Anabolism;Animal Model;Anti-Retroviral Agents;antiretroviral therapy;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Attenuated;Automobile Driving;bone;bone cell;bone loss;Bone Marrow;Bone Marrow Cell Transplantation;Bone Marrow Stem Cell;bone mass;Bone Resorption;bone strength;Catabolism;Cell Aging;clinical practice;comorbidity;Data;Development;Diagnosis;Disease Outcome;Disease Progression;emtricitabine;Enzyme Induction;experimental study;falls;Fracture;frailty;Functional disorder;functional outcomes;Funding Opportunities;Future;Gait speed;Genes;Goals;Hand Strength;Health;HIV;HIV Infections;HIV-1;HIV/AIDS;improved;In Vitro;in vivo evaluation;Inflammation;Inflammatory;inhibitor;innovation;Intervention;Knock-out;Knowledge;Kynurenine;life span;Measures;mechanical properties;Methylation;Molecular;mortality;mouse model;multidisciplinary;Mus;Muscle;Muscle Cells;muscle form;muscle strength;Muscular Atrophy;Musculoskeletal;myogenesis;novel;novel therapeutic intervention;Nuclear;Older Population;Osteogenesis;Osteoporosis;Outcome;overexpression;Oxidative Stress;Pathology;Pathway interactions;patient population;Patients;pharmacologic;Phenotype;Play;poor health outcome;Public Health;Quality of life;Receptor Activation;Resistance;response;Role;sarcopenia;senescence;Signal Pathway;Skeletal bone;Skeletal Muscle;stem cells;substantia spongiosa;targeted treatment;Testing;Thinness;Time;Tissues;Transgenic Mice;Tryptophan;Tryptophan 2,3 Dioxygenase;Wild Type Mouse

PROJECT_TITLE: Novel mechanisms of muscle and bone loss with HIV infection, antiretroviral therapy, and aging.


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Genetics;Human Genome;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE This work identifies molecular signatures explaining why symptoms are more pronounced on one side of the body in Parkinson’s patients. The proposed research benefits public health because it advances our understanding of the biological mechanisms underlying Parkinson’s disease, which in the long-term could serve to improve therapies and reduce the financial burdens associated with this devastating condition.

PI_NAMEs: COETZEE, GERHARD A (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: 3-Dimensional;Acceleration;advanced disease;Affect;Age;age related changes;Aging;alpha synuclein;Appearance;Bilateral;Biological;Brain;brain control;Brain Diseases;Cerebral hemisphere;Characteristics;Chromatin;Clinical;Data;Development;Disease;Disease Progression;DNA Methylation;Elderly;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Financial Hardship;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic analysis;Genetic study;Genetic Transcription;genome-wide;genome-wide analysis;Goals;Health;Human;Impairment;improved;in vivo;Individual;insight;Left;Link;Maps;Molecular;molecular asymmetry;Molecular Profiling;Motor;motor symptom;Mus;Nerve Degeneration;Neurobehavioral Manifestations;Neurodegenerative Disorders;neuron loss;Neuronal Dysfunction;Neurons;neuropathology;nigrostriatal system;non-motor symptom;Outcome;Parkinson Disease;Pathology;Pathway Analysis;Patients;Pattern;Phenotype;pre-clinical;Prefrontal Cortex;Prevalence;Process;progressive neurodegeneration;Public Health;Research;Risk Factors;risk variant;Role;Side;Structure;Subgroup;Symptoms;Synapses;Syndrome;Techniques;transcriptome;transcriptomics;Work

PROJECT_TITLE: Epigenetic contributions to symptom asymmetry in Parkinson's disease

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: anti-cancer research;Appointment;Area;Basic Science;cancer care;Cancer Center;Cancer Center Support Grant;cancer research center director;career;Clinical;Clinical Research;Communities;community advisory board;community engagement;Comprehensive Cancer Center;Development;Doctor of Philosophy;education research;empowerment;Evaluation;experience;Foundations;Funding;Future;Goals;Healthcare;Human;Immunology;Infrastructure;Institution;Investments;Iowa;Leadership;Malignant Neoplasms;meetings;member;Modeling;Molecular Epidemiology;NCI Center for Cancer Research;Obesity;Persons;Phase;Phase I Clinical Trials;Play;Population Sciences;Productivity;recruit;Research;Resources;Role;Strategic Planning;Strategic vision;Students;theranostics;Universities;Update;Vision;Work

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS

PI_NAMEs: MAVIGNER, MAUD  (contact)

PROJECT_TERMS: Adaptive Immune System;Address;Adolescence;Adult;Age;Antibodies;Antigens;antiretroviral therapy;Biological Assay;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Child;Childhood;clinical trial protocol;comparative;Complex;Data;Development;efficacy evaluation;Environment;Excision;Functional disorder;Genetic Transcription;HIV;HIV Infections;humanized mouse;Immune;Immune system;Immune System Diseases;Immunity;Immunologics;Immunology;Immunophenotyping;immunoregulation;In Vitro;in vitro Model;in vivo;Infant;Infection;Innate Immune System;integration site;interdisciplinary approach;Interruption;Investigation;Knowledge;Life;Macaca mulatta;Maintenance;Mediating;microbial;Mission;Modeling;Morbidity - disease rate;mortality;multiple omics;Nature;Neonatal;novel;Output;pathogen;pediatric human immunodeficiency virus;perinatal HIV;perinatal period;pressure;Production;programs;Reproducibility;Research;Research Personnel;Role;simian human immunodeficiency virus;SIV;synergism;T-Lymphocyte;Testing;Thymus Gland;transcriptomics;Viral;Viral Physiology;viral rebound;Viral reservoir;Viremia;Virus


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: DUPUY, ADAM J. (contact)

PROJECT_TERMS: Address;anti-cancer research;Basic Science;Biometry;Cancer Center Support Grant;Cancer Research Project;Clinical Research;Collaborations;college;Comprehensive Cancer Center;Consultations;Data Analyses;design;Development;Education;Effectiveness;Ensure;Equipment;Exercise;Feedback;Flow Cytometry;Free Radicals;Funding;Future;Genomics;Goals;high throughput screening;improved;Individual;Institution;Iowa;Leadership;Malignant Neoplasms;Medicine;member;Microscopy;Molecular Epidemiology;Monitor;new technology;novel strategies;Occupational activity of managing finances;Police;Policies;Population Research;programs;Radiation;Research;research facility;Research Personnel;Research Support;Resource Sharing;Resources;Services;Structure;Technology;Translational Research;Universities;University adminstration;Viral Vector;Work

PROJECT_TITLE: Shared Resource Management


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Cancer;Depression;Mental Health;Mental Illness;Prevention;Prostate Cancer;Rehabilitation;Substance Misuse;Suicide;Urologic Diseases

ORG_CITY: HOUSTON

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: NARRATIVE Prostate cancer survivorship is common and increasing, and may have substantial mental health impacts in patients and their intimate partners that are understudied and preventable. This project will provide the first long-term assessment of mental health outcomes in prostate cancer survivors and their partners by integrating highly complete data from primary care, specialty outpatient, and inpatient settings for a large population- based cohort. The results will identify the long-term mental health sequelae in prostate cancer survivors, their partners, and high-risk subgroups, and guide early interventions to improve their long-term health.

PI_NAMEs: CRUMP, CASEY  (contact);SIEH, WEIVA ;SUNDQUIST, KRISTINA

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: Address;alcohol use disorder;Anxiety;Birth;cancer diagnosis;Cancer Patient;cancer survival;Cancer Survivorship;cancer survivorship care;cancer therapy;Caring;Cause of Death;Cessation of life;Characteristics;Clinical;cohort;cost;cost efficient;Country;Data;Diagnosis;Disease;Distress;Drug Use Disorder;Early Intervention;Education;Educational workshop;Ethnic Origin;follow-up;Health;high risk;Hospitals;improved;Incidence;Income;Individual;innovation;Inpatients;Intervention;Knowledge;Long-Term Care;Longitudinal Studies;Major Depressive Disorder;Malignant neoplasm of prostate;Malignant Neoplasms;Marital Status;medical specialties;men;Mental Depression;Mental disorders;Mental Health;Military Personnel;Modeling;mortality;Operative Surgical Procedures;Outcome;Outpatients;Patients;Persons;Population;population based;Predisposition;premature;prevent;Primary Care;prostate cancer survivors;Prostate Cancer therapy;psychosocial;Public Health;Quality of life;Race;Radiation;Registries;Relative Risks;Research;Risk;Risk Assessment;Sample Size;Self Care;Sexual Dysfunction;side effect;Spouses;Stress;stress resilience;Subgroup;Suicide;Suicide attempt;Sweden;Testing;Time;tumor;United States National Institutes of Health;Urinary Incontinence;Vulnerable Populations

PROJECT_TITLE: Long-Term Mental Health Outcomes in Prostate Cancer Survivors and Their Partners

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]