NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Immunization;Immunotherapy;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative Because of the problems associated with recurrent ocular infection, reducing establishment of latency and reactivation should be a major goal of controlling ocular HSV-1 infection. We now plan to determine if suppression of CD80 by HSV-1 ICP22 gene affects virus replication in the eye, eye disease and latency- reactivation. We also plan to evaluate the negative effect of CD80 on eye disease using a combination of recombinant ICP22 viruses, knockout mice and transgenic mice.

PI_NAMEs: GHIASI, HOMAYON  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acceleration;acute infection;Adverse effects;Affect;Antibodies;Apoptotic;Back;Binding;Binding Sites;Blindness;C57BL/6 Mouse;CD28 gene;CD8-Positive T-Lymphocytes;CD80 gene;CD8B1 gene;Cessation of life;Cicatrix;clinically significant;Compensation;Cornea;corneal scar;CTLA4 gene;design;Developed Countries;DNA;exhaustion;Eye;Eye diseases;Eye Infections;Failure;Funding;Ganglia;Genes;Goals;Herpes stromal keratitis;Herpesvirus 1;Herpetic Keratitis;Immune;immune cell infiltrate;immune clearance;Immune Evasion;Immune response;Immune system;Immunize;immunogenicity;In Vitro;in vivo;Inbred BALB C Mice;Individual;Infection;Inflammatory Response;Knockout Mice;latent infection;Light;Maps;Mediating;Methods;mouse model;Mus;Mutate;neutralizing antibody;novel;novel strategies;overexpression;Pathology;Phase;Play;Predisposition;prevent;Primary Infection;Production;programmed cell death ligand 1;programmed cell death protein 1;promoter;prophylactic;Publishing;reactivation from latency;recombinant virus;Recombinants;Recurrence;Recurrent disease;recurrent infection;Role;side effect;Simplexvirus;Structure of trigeminal ganglion;T cell response;T-Lymphocyte;Testing;Therapeutic;Time;Transgenic Mice;Travel;vaccine trial;Vaccines;Viral;Viral Eye Infections;Viral Load result;Virion;Virus;Virus Replication

PROJECT_TITLE: Therapeutic control of HSK by CD80


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: OVERALL MEDICAL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PORTLAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The importance of myelination is highlighted by the devastating neurological symptoms that accompany diseases such as leukodystrophies and multiple sclerosis. Despite myelin’s essential function in maintaining the health of the CNS, the precise molecular mechanisms that regulate its formation have not been fully elucidated. Successful completion of this proposal will help uncover key molecular mechanisms that drive CNS myelination, potentially leading to new therapeutic targets.

PI_NAMEs: COLLINS, HANNAH YOUNG (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Action Potentials;Appointment;Axon;axonal degeneration;Biological Models;career;Cell Lineage;cell motility;Cell Proliferation;cell type;Cells;Central Nervous System;Complex;Cullin Proteins;Demyelinating Diseases;density;Development;Disease;Dorsal;FBXW7 gene;Genetic;Genetic Models;Genetic Screening;Growth;Health;Homeostasis;Individual;innovation;Institution;Knock-out;Laboratories;Length;leukodystrophy;Life;Ligase;loss of function;Maintenance;Mammals;Membrane;Methods;Modeling;Molecular;Morphology;mouse genetics;mouse model;Multiple Sclerosis;Mus;mutant;Mutant Strains Mice;Myelin;Myelin Basic Proteins;Myelin Sheath;myelination;Neuroglia;Neurologic Symptoms;Neurosciences Research;new therapeutic target;novel;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Optic Nerve;Population;precursor cell;Process;protein B;protein degradation;protein expression;Protein Isoforms;Proteins;Proteomics;Regulation;remyelination;response to injury;RNA Splicing;Rodent;Rodent Model;Role;Science;skills;Speed;Spinal Cord;Thick;Time;Training;transcription factor;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Zebrafish

PROJECT_TITLE: Control of CNS Myelination by the E3 Ligase Component Fbxw7


ADMINISTERING_IC: ES

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: CORVALLIS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: OREGON STATE UNIVERSITY

PHR: PROJECT NARRATIVE The Oregon State University Center for Advancing Science, Practice, Programming and Policy in Research Translation for Children's Environmental Center (ASP3IRE Center) seeks to close this “environmental health gap” by bridging the fields of health promotion and environmental health science. By following best practices of implementation and dissemination science, the research and activities in this Center will accelerate the uptake of evidence-based interventions that will target children's environmental health issues in in high-risk populations.

PI_NAMEs: KILE, MOLLY L (contact);MCCLELLAND, MEGAN M

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 4 year old;Acceleration;Area;authority;care coordination;Catalogs;catalyst;Child;Child Development;Child Health;Collaborations;Communities;community organizations;community partners;community setting;County;Data Science;Databases;Development;dissemination science;early childhood;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Environmental Health;Equity;equity, diversity, and inclusion;evidence base;Evidence based intervention;Exposure to;Family;Feeds;Gatekeeping;Generations;Grant;Health;health care service utilization;Health Hazards;health knowledge;Health Personnel;health plan;health practice;Health Professional;Health Promotion;health training;Healthcare;high risk population;Home;implementation intervention;implementation science;implementation strategy;improved;Infrastructure;innovation;Intervention;Investments;Laboratories;laboratory development;Learning;member;Methods;Mission;Modeling;novel;Nursery Schools;Oregon;Partnership Practice;Persons;Play;Policies;Population;Predisposition;Prevention;programs;recruit;repository;Research;Research Personnel;research to practice;resilience;Resources;Schools;Science;Scientist;Services;social;social media;System;Testing;Time;tool;Training;training opportunity;Translating;translational health science;Translational Research;Translations;Trust;United States;Universities;uptake;web portal;welfare;Work

PROJECT_TITLE: Advancing Science, Practice, Programming and Policy in Research Translation for Children's Environment Health (Asp3ire)


NIH_SPENDING_CATS: Pediatric

PI_NAMEs: KILE, MOLLY L (contact)

PROJECT_TERMS: Acceleration;Area;authority;Awareness;career development;Career Mobility;Caring;Child;Child Health;Collaborations;Communication;Communities;Compassion;County;Development;Educational workshop;Effectiveness;effectiveness evaluation;Ensure;Environment;Environmental Health;Equity;equity, diversity, and inclusion;Evaluation;Event;Evidence based intervention;Family;Fostering;Funding;Goals;Grant;Health;Health Services;Human Resources;implementation strategy;improved;Infrastructure;innovation;Investments;Knowledge;Leadership;Learning;meetings;member;Mentorship;Mission;Monitor;National Institute of Environmental Health Sciences;operation;Oregon;Performance;Play;Policies;Postdoctoral Fellow;Productivity;programs;Public Health;recruit;Research;Research Personnel;Research Priority;research to practice;Resources;Role;Schools;Science;Services;Structure;symposium;synergism;Training;translational health science;Translational Research;Translations;Trust;United States;Universities;web site


PI_NAMEs: MACDONALD, MEGAN I (contact)

PROJECT_TERMS: automated analysis;Awareness;Behavior;care coordination;Caregivers;catalyst;Child;Child Development;Child Health;Communities;Data;Data Analyses;data integration;Data Science;Development;Devices;digital;Discipline;early childhood;Educational workshop;Effectiveness;Environment;Environmental Exposure;Environmental Hazards;Environmental Health;Epidemiology;expectation;Funding;Grant;Health;Health Hazards;Health Promotion;implementation science;improved;innovation;Institution;interest;Intervention;Knowledge;Mentors;Methods;Mission;novel;Oregon;Parents;Play;Policies;Positioning Attribute;Predisposition;Program Effectiveness;programs;Qualifying;Research;Research Project Grants;Risk;Schools;Science;Scientist;social;social media;Structure;success;teacher;Time;timeline;tool;Training;Translating;translational health science;Translational Research;translational scientist;Translations;Trust;United States;Universities;uptake;Work

PROJECT_TITLE: Advancing Science, Practice, Programming and Policyin Research Translation for Children's Environment Health (Asp3ire)


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: CHARLES R. DREW UNIVERSITY OF MED & SCI

ORG_STATE: CA

PHR: PROJECT NARRATIVE /RELEVANCE TO PUBLIC HEALTH Despite the prevention and treatment efforts of the past 30 years, Latino men who have sex with men (MSM) continue to be disproportionately impacted by HIV nationally, and is particularly a problem in Los Angeles, which is a predominantly Latino minority city. Yet a powerful cultural source of motivation for behavior change has been underutilized: the family. The long-term goal of this K01 is for Dr. del Pino to become an independent investigator and national thought leader (1) to expand our understanding of the impact of family relationships on Latino MSM and how to include them in the development and testing of HIV biomedical interventions and (2) to address HIV and other health disparities in diverse sexual and gender minority communities.

PI_NAMEs: DEL PINO, HOMERO ERWIN (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;Affect;AIDS prevention;Award;Behavior;behavior change;Biometry;Blood;career;career development;Chicago;Cities;Clinic;clinical center;clinical epidemiology;Clinical Research;cohort;Cohort Studies;Collaborations;Complex;Cross-Sectional Studies;Data;Data Analyses;design;Development;Disparity;Effectiveness;efficacy testing;Eligibility Determination;Emotional;epidemiology study;Ethnic Population;experience;Family;Family member;Family Relationship;family support;Federally Qualified Health Center;Focus Groups;follow-up;Funding;gender minority community;Goals;Health;Health behavior and outcomes;health disparity;Heterosexuals;high risk;high risk men;HIV;HIV diagnosis;HIV disparities;HIV Infections;HIV/AIDS;Homophobia;Human immunodeficiency virus test;Individual;Infrastructure;Intervention;intervention refinement;Interview;Knowledge;Latino;Latino Population;life span;Long-Term Effects;Los Angeles;Medicine;men of color;men who have sex with men;Mental Health;Mentors;Mentorship;mid-career faculty;Minority;Motivation;National Center for Advancing Translational Sciences;National Institute of Drug Abuse;National Institute of Mental Health;National Institute on Minority Health and Health Disparities;Paper;Perception;Pharmacy facility;Philosophy;physical conditioning;pilot test;pre-exposure prophylaxis;prevent;Prevention;prevention service;preventive intervention;Procedures;Process;Prospective, cohort study;Public Health;public health research;Publishing;racial population;recruit;Reporting;Research;Research Personnel;Research Priority;Resources;Risk;Risk Behaviors;Risk Reduction;Safe Sex;Science;Sex Behavior;Sexual and Gender Minorities;Siblings;social stigma;Social support;Source;stem;substance use;System;Testing;Theoretical model;therapy development;Time;Training;Translational Research;treatment services;Universities;uptake;Urine;Viral;Viral Load result;willingness;Work;Youth

PROJECT_TITLE: Understanding and Engaging Families in HIV Biomedical Prevention for Latino Men Who Have Sex with Men


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric;Prevention;Social Determinants of Health

PI_NAMEs: MCCLELLAND, MEGAN M (contact)

PROJECT_TERMS: Acceleration;Achievement;Address;Adherence;Affect;Air;Applications Grants;authority;Behavioral;Behavioral Sciences;built environment;care coordination;Chemicals;Child;Child Development;Child Health;Child Welfare;Clinic;Cognitive;Collaborations;Communities;Community Practice;Complement;Coupled;Development;Discipline;Disease;early childhood;Education;Environment;Environmental Hazards;Environmental Health;Environmental Impact;Environmental Science;Evaluation;evidence base;Evidence based intervention;expectation;Exposure to;Family;Funding;Goals;Grant;hazard;Health;Health behavior;Health Promotion;Healthcare;improved;Individual;Information Systems;Infrastructure;Institution;interdisciplinary approach;Intervention;Investments;Knowledge;Life;Medicaid;Methods;Mission;Modeling;National Institute of Environmental Health Sciences;Oregon;Outcome;Personal Satisfaction;Policies;Policy Maker;prevent;programs;promote resilience;Public Health;Public Health Practice;Research;Research Personnel;Risk Factors;Science;social;social interventions;System;theories;timeline;Training;Translating;translational health science;Translational Research;Translations;United States Environmental Protection Agency;Universities;uptake;Water Pollution;Work


ADMINISTERING_IC: DK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE In contemporary practice for people with HIV, type 2 diabetes mellitus, obesity, and food insecurity (insufficient access to enough food for an active, healthy life) are major threats to health. The proposed research program will significantly advance our understanding of how to best address food insecurity in the context of diabetes management for people with HIV, by testing an innovative medically tailored meal delivery + lifestyle intervention for individuals with food insecurity, diabetes, and HIV. This intervention has the potential to improve health and reduce the impact of food insecurity among people with HIV and diabetes.

PI_NAMEs: BERKOWITZ, SETH A (contact)

PROGRAM_OFFICER_NAME: RAJAPAKSE, NISHADI

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;active comparator;Address;Adult;Affect;Aftercare;Aging;Anti-Retroviral Agents;Asian ancestry;Behavior;behavior change;Body mass index;Body Weight decreased;cardiometabolic risk;Cardiovascular Diseases;Caring;Chronic;Chronic Kidney Failure;Clinical;Cognitive;combat;Communities;comorbidity;comparative effectiveness trial;comparison group;Complications of Diabetes Mellitus;Data;diabetes control;diabetes distress;diabetes management;Diabetes Mellitus;diabetes risk;diabetes self-management;Diet;Dietitian;Dimensions;Distress;effective intervention;Effectiveness;Enrollment;Environment;evidence base;experimental study;Food;food insecurity;food quality;food security;General Population;Glycosylated hemoglobin A;Goals;group intervention;Health;Health behavior;HIV;Home;improved;Individual;Inflammation;innovation;Intervention;intervention effect;Interview;Knowledge;Life;lifestyle intervention;Medical;Medicine;Metabolic;Methods;Modeling;Modernization;Non-Insulin-Dependent Diabetes Mellitus;nutrition education;Nutritional;Obesity;obesity management;obesogenic;Outcome;Participant;Pathway interactions;Patient Outcomes Assessments;Patients;Persons;Pharmaceutical Preparations;Positioning Attribute;Premature Mortality;Prevalence;primary outcome;programs;psychologic;Quality of life;Randomized;randomized trial;randomized, clinical trials;recruit;Reporting;Research;response;Risk;Role;secondary analysis;secondary outcome;Self Efficacy;skills;standard of care;Structure;Testing;therapy design;tool;Treatment Efficacy;Variant;Weight;Weight Gain

PROJECT_TITLE: Food as Medicine for HIV: A Randomized Trial of Medically Tailored Meals and Lifestyle Intervention


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: PITTSBURGH

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: This proposal develops an acellular therapy for the in vivo regeneration of the mandibular condyle cartilage of the temporomandibular joint using a novel multi-layer scaffold design and biomaterials. The novel scaffold design will be used to recapitulate the native tissue architecture. Furthermore, we have developed a novel clinically relevant injury model for the TMJ in goats, which is used in the proposed studies.

PI_NAMEs: ALMARZA, ALEJANDRO JOSE (contact);TABOAS, JUAN MANUEL

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 4 year old;Adult;Architecture;articular cartilage;Articulation;base;Bilateral;Binding;Biochemical;Biocompatible Materials;Biological Assay;Biological Availability;bioscaffold;BMP2 gene;bone;Bone Regeneration;Cartilage;cartilage degradation;cartilage regeneration;cartilaginous;Cells;Chondrocytes;Chondrogenesis;clinically relevant;condylar cartilage;costal cartilage;Data;Defect;design;Diffusion;ethylene glycol;Family suidae;Fibroblasts;Fibrocartilages;fibula;Functional Regeneration;Gelatin;Goat;Growth;healing;Heparin;Heparin Binding;Hyaline Cartilage;Hydrogels;Implant;implant design;In Vitro;in vivo;in vivo regeneration;Infiltration;Injury;Kinetics;Liquid substance;Mandible;Mandibular Condyle;Mandibular Scaffold;mechanical load;mechanical properties;migration;Miniature Swine;Modeling;Nanoporous;Natural regeneration;novel;osteochondral tissue;Osteogenesis;osteoprogenitor cell;Pain;Pathology;Patients;Perfusion;Periodicity;Permeability;Phenotype;Polymers;Porifera;prevent;progenitor;Property;Publishing;regeneration potential;regenerative;Regenerative research;regenerative therapy;regenerative treatment;Replacement Arthroplasty;scaffold;Shapes;Site;stem cell population;stem cells;subchondral bone;Technology;Temporomandibular Joint;Temporomandibular Joint Disorders;Time;Tissue Engineering;tissue regeneration;Tissues;Transforming Growth Factor beta;treatment effect

PROJECT_TITLE: Polymer Scaffolds for Mandibular Condyle Cartilage Regeneration

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: Nashville

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative: Cataract is the primary cause of blindness in the world and, with surgery as the most common treatment, it costs the US healthcare system billions of dollars each year. Major lens membrane proteins, AQP0 and Lim2 are essential for lens transparency and an understanding of the roles that these proteins play in cataract formation will allow therapies to be developed to prevent, treat or delay its onset. This proposal focuses on structural analysis of these two lens membrane proteins using advanced mass spectrometry techniques with the goal of elucidating the role that protein-protein and protein-lipid interactions play in cataract development.

PI_NAMEs: O'NEALE, CARLA  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adhesions;Adopted;Affect;Age;Binding;Biological Assay;Blindness;C-terminal;Calcium-Binding Proteins;Calmodulin;Cataract;Cell Adhesion;cell water;Chemicals;common treatment;Complement;cost;crosslink;Crystalline Lens;Data;Deuterium;Development;Environment;experimental study;fiber cell;Functional disorder;Galectin 3;Generations;Goals;Healthcare Systems;Homeostasis;Human;Hydrogen;insight;Integral Membrane Protein;lens;Lens Fiber;lens transparency;Life;Link;Lipid Binding;Lipids;Mass Spectrum Analysis;Membrane;Membrane Proteins;Microcirculation;MIP gene;molecular dynamics;Mus;Mutation;Nutrient;Operative Surgical Procedures;Permeability;Physiological;Play;prevent;Property;Protein Analysis;Protein Dynamics;protein function;protein structure;Proteins;reconstitution;Regulation;Reporting;Research Personnel;Role;Site;Structure;System;Tail;Techniques;Testing;therapeutic development;therapeutic target;Tissues;Vascular blood supply;Vision;wasting;Water;water channel

PROJECT_TITLE: Structural analysis of protein-protein and protein-lipid interactions of lens membrane proteins.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: ANN ARBOR

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: This proposal centers on the impact of atypical, shortened (s) TDP43 isoforms in the pathogenesis of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The studies described here will uncover the prevalence of sTDP43 deposition in sporadic and familial FTD/ALS, illustrate downstream consequences of sTDP43 accumulation for RNA homeostasis, and determine the contribution of sTDP43 to neurodegeneration in FTD/ALS disease models. Our aim is to highlight a heretofore-undiscovered disease mechanism responsible for neurodegeneration in TDP43-related FTD/ALS, paving the way for effective therapeutic approaches that prevent sTDP43 deposition.

PI_NAMEs: BARMADA, SAMI  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Address;Affect;ALS patients;Alternative Splicing;Amino Acids;Amyotrophic Lateral Sclerosis;Antibodies;Automobile Driving;Autopsy;Binding;Brain;C9ORF72;Cell Death;Cell Nucleus;Characteristics;Clinical;cohort;CRISPR/Cas technology;Cultured Cells;Cytoplasm;Data;Deposition;design;Disease;disease model;Disparate;Exclusion;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Generations;Genome engineering;Goals;Homeostasis;human induced pluripotent stem cells;Hyperactivity;In Vitro;in vivo;Induced Mutation;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Label;Length;Link;locked nucleic acid;Michigan;Modeling;mutant;Mutation;Nerve Degeneration;neuron loss;Neurons;neuroprotection;novel;novel therapeutics;Nuclear;Nuclear Export;Nuclear Protein;overexpression;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Play;Prevalence;prevent;Production;Protein Isoforms;protein TDP-43;Proteins;Reagent;Reporter;RNA;RNA Splicing;RNA-Binding Proteins;Rodent;Specificity;Stress;stress granule;stressor;targeted treatment;Testing;Therapeutic;therapeutically effective;therapy development;Time;Tissues;Toxic effect;Transcript;Universities

PROJECT_TITLE: Atypical TDP43 isoforrms driving neurodegeneration in FTD/ALS

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Networking and Information Technology R&D (NITRD);Nutrition;Precision Medicine;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: DAVIS

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative Individuals with diverse backgrounds, behaviors, health issues, exposures and dietary habits may have different metabolic responses to food components and patterns of eating with important health and wellness implications. To identify predictive characteristics for specific nutritional responses with health risks or benefits to the individual, this study proposes to capitalize on the unprecedented scope and scale of the All of Us Research Program by adding dietary response assessment data in an ancillary sub-cohort, and by utilizing technologies for multi-omics, microbiome, and wearable devices. A prototype challenge meal and three distinct dietary patterns are proposed with the expectation that responses to both macro- and micro-nutrients in a diverse cohort will reflect the distribution of physiologic response phenotypes in the population.

PI_NAMEs: ADAMS, SEAN HARRISON;BENNETT, BRIAN JOSEPH;BOROWSKY, ALEXANDER D (contact);GOODMAN, MARC T;LI, ZHAOPING ;STEINBERG, FRANCENE M

PROGRAM_OFFICER_NAME: CLARK, DAVID

PROJECT_TERMS: Address;All of Us Research Program;Artificial Intelligence;Behavior;Big Data;Big Data Methods;Biological Markers;biological systems;Blood;blood glucose regulation;California;Carbohydrates;Cessation of life;Characteristics;Chemistry;Chronobiology;clinical center;Clinical Nutrition;cohort;Collaborations;Collection;Communication;Communities;community advisory board;community based participatory research;Complex;Consent;Coupled;Crossover Design;Data;Data Collection;data modeling;data sharing;design;Diet;Diet Habits;dietary;Dietary Intervention;Dietary Practices;digital applications;Disparate;Domiciles;Eating;Eating Behavior;Ecology;Electronic Health Record;Emerging Technologies;Enrollment;Environment;Environmental Risk Factor;Epigenetic Process;expectation;experience;Exposure to;Fatty acid glycerol esters;feeding;Food;Genetic;genomic data;Goals;gut microbiota;Health;Health Food;Health Personnel;Hormones;Human;Hunger;improved;indexing;Individual;individual response;individual variation;innovation;inter-individual variation;Intervention;Kinetics;Lipids;Macronutrients Nutrition;Marketing;Measurement;Measures;Medical center;member;Metabolic;Metabolism;metabolomics;Metagenomics;metatranscriptomics;Methods;Microbe;microbiome;microbiota;Micronutrients;Modernization;multiple omics;National Health Programs;Nature;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Nutritional;Nutritional Science;Nutritionist;organizational structure;Outcome;Participant;Pattern;personalized nutrition;Persons;Phase;Phenotype;Physical activity;Physiological;Physiology;Phytonutrients;Population;Population Heterogeneity;Precision Health;precision medicine;precision nutrition;Prediabetes syndrome;premature;programs;Protocols documentation;prototype;psychosocial;Public Health;Recommendation;recruit;Research Design;response;Risk;Rural Community;Satiation;sedentary lifestyle;Shapes;social factors;Standardization;Subgroup;suburban communities;synergism;System;Technology;Testing;Time;Training;Type 2 diabetic;Unhealthy Diet;United States National Institutes of Health;Urban Community;Urine;wearable device

PROJECT_TITLE: California Partnership for Personalized Nutrition


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Disability Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Prevention;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Despite treatment advances, people with HIV (PWH) often still develop neurologic problems. CHARTER Plus will provide a resource of research data and biospecimens to enable innovative studies that investigate neurologic, cognitive, psychiatric, and drug use disorders across the lifespan in PWH.

PI_NAMEs: ELLIS, RONALD J.;LETENDRE, SCOTT L (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Address;Adult;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;antiretroviral therapy;Area;Behavioral;Behavioral Sciences;Biological;Biological Markers;Biological Specimen Banks;biopsychosocial;Blood;Blood Vessels;Central Nervous System;Cerebrospinal Fluid;Certification;Characteristics;co-infection;Cognitive;cognitive disability;cohort;Collaborations;Collection;Communication;comorbidity;comparison group;Consultations;Data;Data Analyses;Data Coordinating Center;data management;data repository;Dementia;Development;Diagnosis;Dimensions;disability risk;Disease;Disparity;Drug usage;Drug Use Disorder;effective therapy;Emotional;Equipment and supply inventories;Ethnic Origin;Evaluation;experience;Family history of;Feces;fighting;Funding Agency;Future;Genetic;health disparity;healthspan;HIV;HIV anti-retroviral;HIV diagnosis;HIV Infections;Human Resources;Immunologics;Immunology;Impaired cognition;improved;Incidence;Inflammation;innovation;Knowledge;Life;life span;Link;Long-Term Effects;Machine Learning;Maps;Medical;meetings;Mental Depression;Mental disorders;Mental Health;Methods;National Institute of Mental Health;National NeuroAids Tissue Consortium;Nervous System Physiology;neuroAIDS;neurobehavioral;neuroimaging;Neurologic;Neurological disability;neuropsychiatry;Older Population;operation;Outcome;Participant;peer;Persons;Phenotype;pre-exposure prophylaxis;premature;Premature aging syndrome;prevent;psychiatric disability;Publishing;quality assurance;Quality Control;Race;Recording of previous events;recruit;Research;Research Design;Research Domain Criteria;Research Personnel;Research Priority;Research Project Grants;Research Support;Resources;response;Risk;Risk Behaviors;Saliva;senescence;sex;Site;Spinal Puncture;Subgroup;Substance Use Disorder;syndemic;Therapeutic;tool;Training;Urine;Viral;virology;weapons;web portal;Work

PROJECT_TITLE: CHARTER Plus: A resource for cutting-edge research on neurological function and mental health in people with HIV and substance use disorders across the lifespan


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: AMHERST

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative The studies proposed in this application assess mechanisms by which the hormone amylin suppresses food intake and body weight by influencing macronutrient intake, with particular focus on its actions in the ventral tegmental area (VTA), a key nucleus in the brain important for feeding and other motivated behaviors. Understanding the integrated mechanisms by which amylin acts in the brain to promote negative energy balance may shed light onto novel mechanisms of action for energy balance control, and thus may provide insight into novel pharmacological targets and strategies for the treatment of obesity.

PI_NAMEs: MIETLICKI-BAASE, ELIZABETH GENEVIEVE (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Acute;Address;Affect;amylin receptor;Appetite Depressants;Area;Automobile Driving;Award;Behavioral;Behavioral Mechanisms;Body Weight;Body Weight decreased;Brain;Carbohydrates;Cell Nucleus;Cells;Central Nervous System;Chronic;Communication;Consumption;Cost of Illness;Dependovirus;design;Development;Diet;dietary;Dopamine;dopaminergic neuron;Eating;energy balance;Estradiol;Estrous Cycle;Fatty acid glycerol esters;Feedback;feeding;Female;Food;Hormones;Hyperphagia;insight;Intake;interest;islet amyloid polypeptide;knock-down;Light;Liquid substance;Literature;Macronutrients Nutrition;male;Mediating;motivated behavior;Motivation;neural;neuromechanism;Neurons;neurotransmission;novel;Nucleus Accumbens;Obesity;obesity treatment;Ovariectomy;Pancreas;Pathway interactions;peptide hormone;Peptides;Periodicity;Persons;pharmacologic;Pharmacotherapy;Phase;Physiological;Physiology;Population;Publishing;Rattus;Receptor Activation;receptor expression;Receptor Signaling;reduced food intake;Research;response;Rewards;Role;Saccharin;Scanning;Sex Differences;Signal Transduction;Site;Stimulus;Sucrose;System;Testing;treatment strategy;United States;Ventral Tegmental Area;Weight Gain;Work

PROJECT_TITLE: Effects of mesolimbic amylin signaling on macronutrient intake

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Heart Disease;Orphan Drug;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative Heart failure is the most expensive medical problem in the United States, and a major cause of death and disability. While the disease is less common in children, the clinical consequences are similarly severe. Emerging experimental evidence and epidemiologic data suggest that the pediatric heart failure population is distinctly different from adult patients. However, the treatment paradigms remain similar, based almost entirely on data derived from adults. This application will address potential novel treatments for pediatric heart failure.

PI_NAMEs: SUCHAROV, CARMEN C (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Address;Adult;Adverse effects;Age;Arrhythmia;Award;Biocompatible Materials;Bioinformatics;Biological;Biological Markers;Blood Volume;Cardiac;Cardiac Myocytes;Cause of Death;cell growth regulation;Cells;Cessation of life;Child;Childhood;circulating microRNA;Circulation;Clinical;Clinical Data;Clinical Trials;clinically relevant;combinatorial;Cyclic AMP;Data;Death Rate;design;Devices;Dilated Cardiomyopathy;disability;Disease;Economic Burden;epidemiologic data;Etiology;exosome;Faculty;Failure;Fibrosis;Freedom;Functional disorder;Gene Expression;Generations;Health Care Costs;Heart;Heart failure;Home;Hospitalization;Hypertrophy;improved;In Vitro;Infusion procedures;inhibitor;Investigation;Knowledge;lipid metabolism;Malignant Childhood Neoplasm;Malignant Neoplasms;Measurement;Mediating;Medical;Mentorship;Metabolic dysfunction;MicroRNAs;microvesicles;Milrinone;Mitochondria;mitochondrial dysfunction;Molecular;Morbidity - disease rate;mortality;Muscle Cells;Myocardial;Myocardium;Neonatal;novel;novel therapeutics;Outcome;Pathologic;patient oriented research;Patients;pediatric heart failure;Population;preservation;prognostic value;Publishing;Quality of life;Rattus;Recovery;Research;response;Risk;Sampling;Serum;Symptoms;System;Testing;therapeutic target;Time;Tissues;transcriptome;Transplant Recipients;Transplantation;treatment response;United States;Ventricular;Ventricular Function;Vulnerable Populations;Work

PROJECT_TITLE: Investigations of Pathologic Remodeling Using Pediatric Heart Failure Serum


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Most melanomas fail to anti-PD1 because of lack of immune cells within the tumors. Our proposed study will look at how a newly identified pathway on tumor vasculature comprises a resistant mechanism to limit immune cell infiltration into melanoma, with the aim of targeting this pathway to improve melanoma therapy.

PI_NAMEs: ZHU, YUWEN  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Angiogenic Factor;anti-PD-1;anti-PD1 therapy;Binding;Biological;Blocking Antibodies;Blood Vessels;cancer immunotherapy;cancer therapy;cancer type;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Adhesion Molecules;Cells;Clinical;Confocal Microscopy;Drug Delivery Systems;Endothelium;Exclusion;Extravasation;Feedback;Functional disorder;Genes;Goals;Human;Hypoxia;Image;Immune;immune cell infiltrate;immune checkpoint blockers;immune function;Immunologics;Immunotherapy;improved;in vivo;Infiltration;inhibiting antibody;insight;KDR gene;Ligands;Lymphocyte Function;Lymphocytic Infiltrate;Malignant Neoplasms;Melanoma;Melanoma patient;Melanoma Tumor;migration;Modeling;Molecular;Monoclonal Antibodies;Mus;Myeloid-derived suppressor cells;Neoplasm Metastasis;Neoplasms in Vascular Tissue;novel;novel strategies;novel therapeutic intervention;Outcome;Pathway interactions;Patients;PD-1 inhibitors;PD-1/PD-L1;Perfusion;Physiologic Neovascularization;Relapse;Research;Resistance;resistance mechanism;Role;Shapes;Signal Transduction;Specimen;T cell infiltration;T-Lymphocyte;Testing;Therapeutic;therapeutic evaluation;Tissues;Toxic effect;tumor;tumor growth;tumor hypoxia;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Up-Regulation;vascular abnormality;Vascular Diseases;Vascular Endothelial Growth Factors;Vegf Inhibitor;Visualization

PROJECT_TITLE: The CD93 pathway and melanoma therapy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project narrative TDP-43 aggregation is a common feature of many neurodegenerative diseases and myopathies. In this proposal I will isolate TDP-43 aggregates from skeletal muscle and test the hypothesis that muscle-derived TDP-43 aggregates can be transmitted in a retrograde manner to the brain. The proposed experiments have the potential to change the current understanding of the spread of pathology in several neurodegenerative diseases.

PI_NAMEs: LYNCH, EILEEN MARIE (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: alpha synuclein;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyotrophic Lateral Sclerosis;Atrophic;Behavior;Biological Assay;Biopsy;Biosensor;Brain;Brain region;Cell Line;Cell Nucleus;Cells;Cellular Stress;Central Nervous System;Coculture Techniques;cognitive change;Collaborations;Competence;Cytoplasm;Cytoplasmic Granules;Dementia;Development;Diagnosis;Disease;enhancing factor;Environment;experimental study;Fluorescence Resonance Energy Transfer;Frontotemporal Dementia;Future;Hindlimb;Human;improved;In Vitro;in vivo;Induced pluripotent stem cell derived human neuron;Inflammation;Injections;Intramuscular;Intramuscular Injections;Link;Methods;misfolded protein;Monitor;Motor;motor impairment;mouse model;multisystem proteinopathy;Mus;Muscle;muscle form;Mutate;Mutation;Myoblasts;Myopathy;Natural regeneration;Necrosis;Nerve Degeneration;Neurodegenerative Disorders;Neuromuscular Diseases;Neurons;neurotransmission;novel diagnostics;novel therapeutics;Nuclear Localization Signal;Parkinson Disease;Pathogenicity;Pathologic;Pathology;Patients;Phosphorylation;protein aggregation;protein TDP-43;Proteins;Qualifying;Recombinants;Research;Research Personnel;Resources;RNA-Binding Proteins;sensor;Skeletal Muscle;Spinal Cord;Stress;stress granule;Structure;superoxide dismutase 1;Symptoms;System;tau aggregation;TDP-43 aggregation;Testing;Time;timeline;Training;transmission process;Wild Type Mouse

PROJECT_TITLE: Retrograde transmission of pathogenic TDP-43 to the CNS

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Lung;Lung Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Histological transformation from lung adenocarcinoma (LUAD) to small cell lung cancer (SCLC) and subsequent diversification into more aggressive SCLC subtypes, are examples of neuroendocrine lineage plasticity, a process that promotes metastasis and treatment resistance in lung cancer. This proposal uses 1) single-cell sequencing in patient tumors of combined LUAD/SCLC histology and 2) functional experiments in preclinical models of SCLC transformation to identify transcriptomic and epigenetic changes driving lineage plasticity. These molecular drivers may identify a novel class of drug targets that ablate lineage plasticity, with therapeutic implications in not just lung cancer but also any cancer type where small cell transformation may arise.

PI_NAMEs: CHAN, JOSEPH MINHOW (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Ablation;Advisory Committees;ASCL1 gene;ATAC-seq;Atlases;Automobile Driving;BETA2 protein;biomarker identification;cancer cell;Cancer Center;Cancer Histology;Cancer Model;cancer subtypes;cancer type;career;career development;Cell Nucleus;cell transformation;Cells;Chemoresistance;Classification;Clinical;cohort;Collaborations;Computing Methodologies;Doctor of Philosophy;Drug Targeting;ELF3 gene;Environment;Epidermal Growth Factor Receptor;Epigenetic Process;epigenetic regulation;experience;experimental study;Faculty;Funding;Genes;genetic manipulation;Genetic Markers;Genetic Transcription;Genomics;Goals;Histologic;Histology;Human;In Vitro;in vivo;in vivo Model;innovation;Knock-out;laboratory experience;Lasers;Libraries;Lung;Lung Adenocarcinoma;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Medical Oncology;Memorial Sloan-Kettering Cancer Center;Mentors;Modeling;Molecular;molecular marker;Mus;Mutation;Neoplasm Metastasis;Neurosecretory Systems;Non-Small-Cell Lung Carcinoma;notch protein;novel drug class;Oncogenic;overexpression;Patient Care;patient derived xenograft model;Patients;Phenotype;Physicians;Play;Population;pre-clinical;Pre-Clinical Model;preclinical study;Preparation;pressure;prevent;Process;programs;RB1 gene;Recurrence;Relapse;Research;research and development;Research Proposals;Resistance;Resources;Risk;RNA;Role;Sampling;Scientist;Signal Transduction;single cell sequencing;single-cell RNA sequencing;skills;small cell lung carcinoma;targeted treatment;tenure track;Therapeutic;therapeutic target;therapy resistant;TP53 gene;Training;transcription factor;transcriptomics;tumor;tumor heterogeneity;Validation;Variant;whole genome

PROJECT_TITLE: Uncovering Epigenetic and Transcriptional Drivers of Neuroendocrine Plasticity at Single-Cell Level in Patients with Small Cell Lung Cancer Transformation

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Relevance: HGSC is the most lethal form of ovarian cancer and remains largely incurable. CCNE1amp HGSC has a particularly poor prognosis, as it fails to respond to platinum-based therapy. By developing and characterizing sophisticated new mouse and human models of CCNE1amp HGSC, we hope to develop new therapeutic strategies for this deadly disease.

PI_NAMEs: HACKER, KARI E;NEEL, BENJAMIN G. (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Affect;Angiogenesis Inhibitors;anti-CTLA4;anti-PD-L1;Apoptosis;Behavior;Biological;Biology;BRCA1 gene;BRCA2 gene;Cancer Biology;CCNE1 gene;cell behavior;cell transformation;Cells;Cessation of life;chemokine;chemotherapy;Credentialing;CXCL10 gene;cytokine;Disease;Disease Resistance;Doxorubicin;Engineering;Epithelium;Event;Expanded CRISPR-compatible cellular indexing of transcriptomes and epitopes by sequencing;FDA approved;Flow Cytometry;gemcitabine;gene repair;Generations;genomic profiles;Genomics;Goals;granulocyte;homologous recombination;Human;human model;immune checkpoint blockade;Immunity;Immuno-Chemotherapy;Immunocompetent;Immunofluorescence Immunologic;Immunohistochemistry;improved;In complete remission;In Vitro;in vivo;inhibitor;Injections;insight;Invaded;Kinetics;Knockout Mice;Malignant neoplasm of ovary;Mammalian Oviducts;Memory;Modeling;Molecular Abnormality;mouse model;Mus;mutant;Mutation;Myeloid-derived suppressor cells;neoplastic cell;NF1 gene;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Organoids;Other Genetics;Outcome;Output;Ovarian;Ovarian Carcinoma;overexpression;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phenotype;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;potential biomarker;Prognosis;Proliferating;Property;prospective;recruit;Regimen;Resistance;response;Serous;Signal Transduction;Subgroup;Surveys;T memory cell;T-Lymphocyte;targeted treatment;taxane;Testing;Therapeutic;Topotecan;transcriptome;tumor;Tumor-Derived;tumor-immune system interactions;Tumorigenicity;Work

PROJECT_TITLE: New Approaches to Modeling and Targeting Cyclin E-amplified High-Grade Serous Tubo-Ovarian Carcinoma

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Mental Health;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Although lifetime prevalence of schizophrenia is equal between sexes, adolescent onset schizophrenia is almost twice as common in males. Dysfunction in prefrontal cortex is a key feature of the disease, and prefrontal cortical circuits develop late in adolescence. This project will examine how microglia, a resident immune cell in the brain that are sexually dimorphic, shape prefrontal circuitry and cognition in typical adolescent development.

PI_NAMEs: HAMM, JORDAN P (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: 3-Dimensional;Adolescence;Adolescent;Adolescent Development;Adult;Anatomy;Animals;Attention;awake;Basic Science;Brain;Brain region;Calcium;cell motility;Cell Physiology;Cells;Cerebral cortex;Cognition;cognitive ability;cognitive development;cognitive function;cognitive reappraisal;Coupling;critical period;CSF1R gene;density;Dependence;Development;Disease;Electronic Medical Records and Genomics Network;emerging adult;Female;Female Adolescents;Foundations;Functional disorder;Future;Goals;Homeostasis;Human;Image;Immune;immune function;in vivo imaging;Inflammatory;inhibitor;insight;Link;male;Measures;Medial;Mediator;Mental disorders;Microglia;Morphology;Motility;Mus;neural;neural circuit;neural network;Neuroglia;Neuroimmune;neuronal circuitry;Neurons;neuroregulation;novel;Odors;Optics;optogenetics;Pattern;pharmacologic;Phase;Physiological;Population;preadolescence;Prefrontal Cortex;Prevalence;Process;psychosocial stressors;PTPNS1 gene;Regulation;response;Rodent;Role;Schizophrenia;sex;Sex Differences;sexual dimorphism;Shapes;spatiotemporal;Surveys;Synapses;Synaptic plasticity;Techniques;Testing;Time;Training;two photon microscopy;two-photon;Vertebral column;Visual Cortex;Work

PROJECT_TITLE: Sex differences in microglia-neuron-circuit interactions in adolescence


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: The ultimate cause of most breast cancer-related deaths is metastasis, the spread of cancer to distant organs. Recent research indicates that in breast cancer, as well as many other tumor types, circulating clusters of tumor cells are associated with therapy resistance, widespread metastases, and significantly worse prognosis. By learning more about these micrometastases, this proposal seeks to identify molecular vulnerabilities that can be used to eradicate them, thereby extending survival in patients with metastatic breast cancer.

PI_NAMEs: CHEUNG, KEVIN JON (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Address;Adhesions;Affinity;Aggressive behavior;anti-cancer research;Apoptosis;Area;Automobile Driving;Biological Assay;Biological Markers;Breast;breast cancer metastasis;Breast Cancer Patient;breast cancer survival;burden of illness;Cancer Patient;cancer recurrence;cancer type;Cell Culture Techniques;Cell Proliferation;Cells;Cessation of life;Clinical;Communities;Cooperative Behavior;Data;Data Set;Disease;Distant;early phase trial;Environment;epidemiology study;Epidermal Growth Factor Receptor;epigen;Event;Feedback;Fos-Related Antigens;Frequencies;Genetic Transcription;Growth;Hematopoietic Neoplasms;Human;human data;improved;In Situ;In Vitro;in vivo;Individual;innovation;Laboratories;Learning;Life;Ligands;Ligation;Light;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Metastatic breast cancer;metastatic process;Metastatic/Recurrent;Methods;Micrometastasis;Modeling;Molecular;mortality;mouse model;multidisciplinary;Mus;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;novel therapeutic intervention;Organ;Organoids;Outcome;Patient-Focused Outcomes;Patients;Play;Positioning Attribute;pre-clinical;prevent;Privatization;Prognosis;programs;Proliferating;Prostate;Protein Tyrosine Kinase;Receptor Activation;Receptor Signaling;Recurrence;Research;Resistance;Resistance development;Role;Sampling;Signal Induction;Signal Transduction;Site;success;Survival Rate;targeted treatment;Testing;Therapeutic;transcription factor;Transcriptional Activation;tumor;women's diagnosis;Work

PROJECT_TITLE: Role of tumor cell cluster-induced signaling in breast cancer metastasis

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative Progressive multiple sclerosis is a common, debilitating disease that currently has no effective treatments. Nanoparticle drug delivery methods capable of reinvigorating glial cells’ ability to produce myelin are promising, but the major limiting factor is the inability to effectively cross the blood-brain barrier to target the right cells. We have developed a strategy to determine how our own natural bioparticles reach these cells, to engineer these abilities into a remyelination-stimulating drug delivery system.

PI_NAMEs: MIZENKO, RACHEL REGINA (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Address;Area;Autoimmune;Biodistribution;Biological Assay;Biological Availability;Biomimetics;Blocking Antibodies;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier penetration;blood-brain barrier permeabilization;brain endothelial cell;career;cell type;Cells;Central Nervous System;clinical translation;Clinical Trials;Coculture Techniques;Data;delivery vehicle;Demyelinations;density;detection limit;Development;differentiation in vitro;Differentiation Inducer;Disease;Disease Progression;Drug Delivery Systems;Drug Targeting;Dyes;Education;effective therapy;Electroporation;Endothelium;Engineering;Exhibits;Experimental Autoimmune Encephalomyelitis;Extracellular Protein;extracellular vesicles;Fluorescence;Goals;Heterogeneity;Immune Targeting;In Vitro;in vivo;in vivo evaluation;Individual;Inflammation;interest;Knowledge;Label;Laboratories;Lesion;Liposomes;Mediating;Medical;Membrane Proteins;Methods;MicroRNAs;Modeling;Molecular;Multiple Sclerosis;Myelin;nanoparticle;nanoparticle drug;National Research Service Awards;Neurodegenerative Disorders;Neuroglia;Neurologic;Neurology;next generation;novel therapeutics;oligodendrocyte progenitor;Oligodendroglia;Pathogenesis;Pathway interactions;Pattern;Pharmaceutical Preparations;Pharmacology;Population;precursor cell;prevent;protein expression;Proteins;receptor;Recovery;remediation;remyelination;Reporting;Resources;Sorting;Source;stem cell differentiation;stem cells;Surface;synthetic drug;System;Technical Expertise;Techniques;Testing;Therapeutic;therapeutically effective;Tissues;trafficking;Training;transcytosis;translational medicine;Universities;Untranslated RNA;uptake;Vesicle

PROJECT_TITLE: Engineered extracellular vesicles as a targeted drug delivery system for multiple sclerosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-U(20)L]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: BLACKSBURG

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative - Relevance  Using the Pavlovian fear conditioning paradigm, the proposed experiments outlined in this document will expand the current literature on the physiological underpinnings of fear memory storage. Enhanced understanding of the biological mechanisms underlying fear memory storage are important not only for increasing our basic knowledge of this process but also for the potential translation of research findings to both normal and disordered memory in humans.

PI_NAMEs: JAROME, TIMOTHY JOSEPH (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Address;Affect;Amygdaloid structure;Animals;Anxiety Disorders;Area;Auditory;Automobile Driving;behavior test;Behavioral;Behavioral Mechanisms;Biological;Brain;cell type;conditioned fear;Cues;Data;design;Development;Disease;Emotional;Empathy;Environment;Etiology;experience;experimental study;fear memory;Female;Focus Groups;foot;Fright;Genetic;genetic manipulation;Genetic Transcription;Goals;Human;Individual;Knowledge;Learning;learning strategy;Literature;male;Memory;memory acquisition;Memory Disorders;Modeling;Molecular;Molecular Profiling;Mutation;neurobiological mechanism;Neurobiology;Patients;Performance;pharmacologic;Pharmacology;Physiological;Population;Post-Traumatic Stress Disorders;Predisposition;Procedures;Process;protein degradation;Proteome;Proteomics;Rattus;response;Rodent;sex;Sex Differences;sex variable;Shock;social;Social Behavior;Stimulus;Symptoms;Testing;Therapeutic Intervention;Training;transcriptome;transcriptomics;translational potential;Translational Research;Translations;traumatic event;Visual;whole genome;Work

PROJECT_TITLE: Behavioral, molecular and sex-specific mechanisms of indirectly learned fear memory

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Hematology;Immunization;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: BINGHAMTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: Project Narrative: There is a critical need for new linker technology for antibody-drug conjugates (ADCs) in order to avoid off-target payload release that drives dose-limiting toxicity. Herein, we propose the optimization and evaluation of novel ADC linkers that are cleaved by legumain. We will optimize the cleavage rate and stability of this linker, demonstrate its efficacy in models of pancreatic cancer, and establish its safety profile in comparison to existing ADC technology.

PI_NAMEs: TUMEY, LAWRENCE  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Address;Alcohols;Amines;Antibody-drug conjugates;Area;Asparagine;asparaginylendopeptidase;Autoimmunity;Behavioral;Biological Assay;Biological Markers;Cancer cell line;Carbamates;Catabolism;Cathepsins;Circulation;clinical application;Communicable Diseases;cytotoxicity;Data;design;Development;Dose Limiting;Drug Kinetics;efficacy evaluation;Ensure;enterotoxin receptor;Enzymes;esterase;Evaluation;Exatecan;Exhibits;FDA approved;Fluorescence Resonance Energy Transfer;foot;Funding;Generations;Goals;Head;head-to-head comparison;Hematology;Human;Hydrophobicity;improved;In Vitro;interest;Left;Leukocyte Elastase;Libraries;Lymphocyte;Lysosomes;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuscripts;Marketing;Measures;Medical;member;Modeling;Mus;Neutropenia;novel;Oncology;Ophthalmology;pancreatic cancer model;Peptide Hydrolases;Peptides;Pharmacologic Substance;Phase II Clinical Trials;Plasma;Predisposition;Process;Rapid screening;Rattus;research clinical testing;Resistance;Safety;screening;side effect;Site;success;System;Technology;Testing;Therapeutic;Thrombocytopenia;Toxic effect;unnatural amino acids;Work;Xenograft Model

PROJECT_TITLE: Legumain to the rescue: A new ADC linker strategy to address the limitations of cathepsin cleavage

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Trypsins are proteins that mediate disease processes in cancer and pancreatitis. More selective inhibitors are needed to target trypsins in order to study the roles of these proteins in diseases and as a stepping stone to developing better drugs to treat these diseases. In this project, we will develop highly selective trypsin inhibitors, along with innovative new methods for studying interactions between proteins that will be applicable to unraveling many disease processes and developing new drugs.

PI_NAMEs: RADISKY, EVETTE S (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Active Sites;Affinity;Allosteric Regulation;Allosteric Site;Binding;Binding Proteins;Biochemical;Biological;Biological Models;Biological Process;Calibration;Catalysis;combinatorial;Computer Analysis;Data;design;Development;dimer;Dimerization;Directed Molecular Evolution;Disease;disease model;Engineering;Enzymes;Family;Future;Generations;Goals;Heterogeneity;Human;in silico;Individual;inhibitor;inhibitor therapy;innovation;insight;International;lead optimization;Libraries;Ligands;Machine Learning;Malignant Neoplasms;Maps;Mediating;Medical;Membrane Proteins;mesotrypsin;Methodology;Methods;Molecular;Molecular Conformation;molecular dynamics;molecular modeling;molecular recognition;monomer;Mutation;Nature;next generation sequencing;novel;novel strategies;novel therapeutics;Pancreatitis;Pathologic;Pathology;Peptide Hydrolases;Peptides;Pharmaceutical Preparations;pharmacologic;Play;Positioning Attribute;Pre-Clinical Model;Process;Productivity;Protease Inhibitor;protein complex;Protein Isoforms;protein protein interaction;Protein-Protein Interaction Map;Proteins;Proteome;Publishing;Regulation;Role;screening;Serine Protease;Shapes;Specificity;Structure;Surface;System;Therapeutic;Therapeutic Agents;therapeutic target;tool;Trypsin;Trypsin Inhibitors;trypsin-like serine protease;Validation;virtual screening;X-Ray Crystallography;Yeasts

PROJECT_TITLE: Exploiting new approaches for selective inhibition of trypsins

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Disability Research;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Project Narrative The causative relationships between global transcriptomic dysregulation in Down Syndrome (DS) and the observed pathological phenotypes in brain cells as well as the development of Alzheimer’s disease (AD) pathology remains unclear. In the current application, we will investigate whether downregulated in trisomy brain expressed X-linked/transcription elongation factor A (SII) (BEX/TCEAL) genes on X chromosome contribute to the global transcriptomic alterations and neurodevelopmental and neurodegenerative cellular phenotypes in DS. Thus, we will assess whether we can mitigate cellular and molecular phenotypes in DS-and AD-related pathology by correcting the dysregulation of the X-chromosome-linked genes in DS-derived cortical spheroids.

PI_NAMEs: ZELDICH, ELLA  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: abeta deposition;Adult;Affect;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Astrocytes;autism spectrum disorder;Autopsy;Binding;Binding Sites;Biology;Brain;brain abnormalities;brain cell;Brain Pathology;brain tissue;Cell Line;Cell model;Cells;Chromosome 21;Cognitive deficits;cognitive disability;Data;Data Set;Deposition;Development;differential expression;Down's Syndrome;Down-Regulation;Early Onset Alzheimer Disease;Evaluation;Exhibits;Family member;Gene Expression;Gene Family;gene product;gene repression;Genes;Genetic;Genetic Transcription;genome-wide;Global Change;Histologic;Human;Human Chromosomes;hyperphosphorylated tau;Individual;induced pluripotent stem cell;Intellectual functioning disability;Link;Mental disability;Mental disorders;Modeling;molecular phenotype;motor disorder;Myelin;myelination;neglect;Neocortex;Nerve Degeneration;Neurons;NGFRAP1 gene;Oligodendroglia;overexpression;Pathologic;Pathology;Patients;Pattern;Phenotype;Play;Prefrontal Cortex;prenatal;preservation;Process;Reporting;Resolution;restoration;Schizophrenia;single-cell RNA sequencing;small hairpin RNA;spheroids;success;Synapses;System;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;Transcript;transcription factor;transcription factor S-II;transcriptome;transcriptomic profiling;transcriptomics;Trisomy;Untranslated RNA;Up-Regulation;X Chromosome;X Inactivation

PROJECT_TITLE: The contribution of X-chromosome-linked genes to cellular phenotypes and AD-related pathology in Down Syndrome

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative  The locomotor central pattern generator (CPG) is thought to be a set of neurons responsible for the generation of rhythmic neuronal activity. Proper assembly and function of the locomotor CPG is essential for the development of normal locomotor rhythm and pattern and therefore, essential to the survival of the animal. We have recently reported that ventral spinocerebellar tract (VSCT) neurons are necessary and sufficient for locomotor behavior. This proposal aims to elucidate the physiological properties, connectivity, and function of VSCT neurons both during development and adulthood using mouse models.

PI_NAMEs: MENTIS, GEORGE Z (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Adult;Anatomy;Animal Behavior;Animal Model;Animals;Automobile Driving;Axon;Behavior;Behavioral Assay;Biological Assay;CAV2 gene;Cells;central pattern generator;Cerebellum;Characteristics;conditional knockout;Confocal Microscopy;Connexins;Coupled;Coupling;Critical Thinking;Data;Dependence;Development;Exhibits;experimental study;Extensor;Flexor;Foundations;Generations;Genetic;genetic approach;Genetic Transcription;Goals;HCN1 gene;HCN4 gene;Image;Immunohistochemistry;in vivo;Individual;Interneurons;knock-down;Knockout Mice;Label;Lasers;Left;limb movement;Limb structure;Locomotion;locomotor control;Maintenance;Maps;Mediating;Molecular;Morphology;Motor;Motor Activity;Motor Neurons;mouse genetics;mouse model;Movement;Mus;Muscle;Neonatal;neonatal mice;neuronal circuitry;Neurons;neuroregulation;Nodal;novel;optogenetics;patch clamp;Pattern;Periodicity;Peripheral;Pharmacology Study;Physiological;Population;postnatal;postnatal development;Property;Protocols documentation;Publishing;Reporting;RNA Interference;Role;Sensory;sensory feedback;Solid;Speed;Spinal;Spinal Cord;Spinocerebellar Tracts;Synapses;Techniques;Testing;transcription factor;two-photon;Viral;Virus;Work;ZFHX3 gene

PROJECT_TITLE: Cellular and Neuronal Circuit Mechanisms Involved in Locomotor Activity

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Back Pain;Biomedical Imaging;Chronic Pain;Clinical Research;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Prevention

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Chronic pain has a staggering economic cost and causes huge suffering to individuals. Once pain is chronic it is very hard to reverse and, hence, the best strategy to prevent chronic pain is early identification and treatment of high-risk individuals. This application aims to identify structural gray and white matter biomarkers of risk and resilience to pain chronification after the onset of low-back pain by testing specific hypotheses based on existing knowledge of chronic pain and the brain while at the same time addressing the influence of sex and types of clinical presentations (i.e., presence or absence of sciatica).

PI_NAMEs: GEHA, PAUL  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Acute;Address;Amygdaloid structure;Anatomy;Anisotropy;Anterior;Area;Back Pain;Biological;Biological Markers;biomarker identification;Brain;brain circuitry;Brain imaging;Chronic;Chronic low back pain;chronic pain;cingulate cortex;Classification;Clinical;clinical phenotype;cost;Data;Deep Brain Stimulation;design;Diagnostic;Diffusion;Diffusion Magnetic Resonance Imaging;Early identification;Early treatment;economic cost;Emotional;External Capsule;Female;follow-up;Globus Pallidus;gray matter;Healthcare Systems;high risk population;Hippocampus;Human;imaging study;improved;Individual;innovation;Internal Capsule;Knowledge;Learning;Light;Limbic System;Low Back Pain;male;Maps;Measures;Mediating;negative affect;Neurites;Neuropathy;Nociception;novel;Nucleus Accumbens;Numeric Rating Scale;Outcome;Pain;pain chronification;Pain Free;pain patient;painful neuropathy;Pathway interactions;Patients;Peripheral;Phenotype;pre-clinical;predict clinical outcome;prevent;Prevention;Preventive treatment;Procedures;Prognostic Marker;Property;Radiculopathy;recruit;Reporting;resilience;resilience biomarker;Resolution;Risk;Risk Marker;risk prediction;Role;Scanning;Sciatica;sex;Shapes;Societies;Structure;Symptoms;Techniques;Testing;Time;translational potential;Ventral Striatum;Visit;water flow;white matter

PROJECT_TITLE: Brain Structural Biomarkers of Risk and Resilience to Pain Chronification

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NPI-N(90)S]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The development of powerful biomarkers, measuring amyloid deposition, tau accumulation, and neurodegeneration, has provided important insights into the pathophysiology of Alzheimer’s disease (AD) and AD-related dementias. Still, we do not understand why some individuals are able to resist pathology while others are more susceptible to cognitive decline. In this proposal, we will investigate two aims with the overall goals of (1) advancing magnetic resonance elastography technology in order to (2) assess the impact of biomechanics, an understudied facet of brain structure, on the pathology-cognition relationship.

PI_NAMEs: MURPHY, MATTHEW CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid deposition;Anatomy;Anisotropy;Atrophic;Biological;Biological Markers;Biomechanics;Brain;Buffers;burden of illness;cardiometabolism;cell motility;Chemicals;Clinic;Clinical Trials;Cognition;Cognitive;cognitive function;cognitive performance;Country;Coupled;Data;Data Discovery;Data Set;Dementia;demographics;design;Development;Diffusion Magnetic Resonance Imaging;Disease;elastography;Environment;experimental study;Face;follow-up;Functional disorder;Future;Goals;Health;imaging modality;Impaired cognition;improved;in vivo;Individual;Inflammatory Response;insight;Knowledge;Learning;Link;Machine Learning;magnetic field;Magnetic Resonance Elastography;Maps;Measurement;Measures;mechanical properties;Mechanics;Microglia;Modality;Modeling;Nerve Degeneration;Neurophysiology - biologic function;Neuropsychological Tests;Noise;Older Population;Pathologic;Pathology;Patient Recruitments;Performance;Persons;Physiological Processes;Play;Positioning Attribute;Positron-Emission Tomography;Predisposition;Process;Prognosis;Relaxation;Reporter;Reporting;Research;resilience;Resolution;Role;Sampling;Signal Transduction;simulation;structural determinants;Structure;success;tau aggregation;tau Proteins;Techniques;Technology;Testing;Therapeutic;tool;Translating;United States;vector;white matter;White Matter Hyperintensity;Work

PROJECT_TITLE: Advancing MR elastography to map mechanical signatures of key AD/ADRD processes

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Although Black men in the United States are disproportionately impacted by diabetes and experience incarceration at very high rates, there is limited research to date on best strategies to improve health outcomes for this population. To address this gap in knowledge, we propose to study MANAGe-DM, a novel nurse case management intervention comprised of three components: diabetes education/skills training, basic needs navigation, and health system navigation in improving glycemic control among Black men with type 2 diabetes with recent release from incarceration.

PI_NAMEs: HAWKS, LAURA C. (contact)

PROGRAM_OFFICER_NAME: RAJAPAKSE, NISHADI

PROJECT_TERMS: Address;Adult;Affect;Aging;American;Anxiety;Behavior;Black American;black men;Black race;Blood Pressure;career development;Caring;Case Management Nurse;Case Manager;caucasian American;Cause of Death;Cessation of life;Cholesterol;Chronic Disease;Clinic;Clinical;Communities;community engaged research;Complication;Country;Death Rate;diabetes control;diabetes education;Diabetes Mellitus;Diet;disorder control;Disparity;effective intervention;empowerment;Exercise;experience;Exposure to;flexibility;food insecurity;Future;glycemic control;Glycosylated hemoglobin A;Goals;Grant;Health;health care delivery;Health Priorities;Health system;Healthcare;Healthcare Systems;Heart Diseases;High Prevalence;Housing;Hypertension;Imprisonment;improved;Income;Individual;innovation;Intervention;intervention effect;Intervention Studies;Knowledge;LDL Cholesterol Lipoproteins;male;Mediator;medication compliance;men;Mental Depression;Modeling;Morbidity - disease rate;mortality;mortality risk;Motivation;Navigation System;Non-Insulin-Dependent Diabetes Mellitus;novel;Nurses;nursing standards;Outcome;Participant;Patient-Focused Outcomes;Patients;peer;Population;Prevalence;prison population;Prisons;Public Health;Quality of life;Race;racial disparity;racial identity;Randomized;Randomized, Controlled Trials;Reinforcing Factor;Research;Risk;Risk Factors;Role;Self Care;Self Efficacy;sex;skills;skills training;social;social structure;Social support;Socialization;Stress;Structural Racism;System;Testing;Training;treatment arm;treatment as usual;Treatment Efficacy;Trust;Unemployment;United States;Vulnerable Populations;Wisconsin;women versus men;Work

PROJECT_TITLE: MANAGe-DM: novel nurse case management to improve diabetes outcomes in Black men recently released from incarceration

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infertility;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Telehealth

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Project Narrative Our overarching objective is to increase engagement in oncofertility care by female and male adolescent and young adult cancer patients at cancer diagnosis, in order to improve their future fertility and quality of life. Through a stepped wedge cluster randomized trial, we will evaluate the effectiveness of three scalable, telehealth interventions (a smart electronic health record screen and referral, telehealth oncofertility counseling, and telehealth financial navigation) in adult and pediatric oncology settings. We will also study how the intervention is implemented to inform future scaling up.

PI_NAMEs: SU, HUI-CHUN IRENE (contact)

PROGRAM_OFFICER_NAME: EVERSON, NICOLE MARIE

PROJECT_TERMS: access disparities;Achievement;Address;Adolescent;Adolescent and young adult cancer patients;Adult;aged;barrier to care;California;cancer care;cancer diagnosis;Cancer Patient;Cancer Survivor;Cancer Survivorship;cancer therapy;care delivery;Caring;Childhood;Clinic;Clinical;clinical care;Clinical Trials;Cluster randomized trial;Collaborations;Conflict (Psychology);Congresses;Counseling;Data;Development;Diagnosis;effectiveness evaluation;Electronic Health Record;Equity;Evaluation;Evidence based practice;experience;Failure;Family;Female Adolescents;Fertility;fertility preservation;Financial Hardship;Frequencies;Future;future implementation;Goals;Guidelines;Health Services;Health system;hybrid type 1 design;implementation evaluation;implementation framework;implementation intervention;implementation science;improved;Incidence;Infertility;innovation;Institution;Intervention;Intervention Studies;Knowledge;Late Effects;Life;Male Adolescents;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical;Methods;Modeling;multi-component intervention;multidisciplinary;Newly Diagnosed;novel;oncofertility;Oncologist;Oncology;Pathway interactions;patient engagement;patient oriented;Patient Outcomes Assessments;Patient Preferences;Patients;Pediatric Oncology;Persons;pilot test;Policies;preservation;prevent;primary outcome;Procedures;Process;psychosocial;psychosocial outcome;Qualitative Methods;Quality of life;Randomized, Controlled Trials;Recommendation;remote delivery;Reporting;reproductive;Research;Risk;scale up;Scanning;Services;shared decision making;Site;Specialist;study population;Technology;telehealth;Testing;Time;tool;treatment as usual;uptake;usability;virtual;young adult

PROJECT_TITLE: Evaluation of a telehealth oncofertility care intervention in adolescent and young adult cancer patients: a stepped wedge cluster randomized controlled trial

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Endocrine Disruptors;Neurosciences;Pediatric;Pregnancy;Sleep Research

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative According to the American Academy of Pediatrics, approximately half of US children experience significant sleep issues, despite the critical importance of sleep to a child’s physical, cognitive, and behavioral development. Exposure to some types of endocrine-disrupting chemicals such as perfluoroalkyl substances (PFAS) have been shown to be associated with sleep outcomes. Our study would be the first to explore the link between individual and mixtures of PFAS during pregnancy and child sleep problems, disturbance, and impairment at ages 2, 3, and 4 years using existing data from a pregnancy cohort study in Illinois.

PI_NAMEs: GEIGER, SARAH  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 4 year old;Academy;Address;Adolescence;Adult;Affect;Age;American;Area;attributable risk;Behavioral;Birth;Blood;Blood Circulation;boys;Characteristics;Chemical Exposure;Child;Child Behavior Checklist;Childhood;Cognitive;Cohort Studies;Complex;cost;Data;Development;early childhood;Endocrine Disruptors;environmental chemical;Environmental Risk Factor;experience;exposed human population;Exposure to;Fetal Development;Fetus;girls;Health;Healthcare;Hormonal;Illinois;Impairment;in utero;Individual;Infant;Information Systems;Link;Literature;maternal serum;Measurable;Measurement;Measures;Modeling;Mothers;neurodevelopment;novel;Nursery Schools;Outcome;Parents;Patient Outcomes Assessments;Pediatrics;Pharmacologic Substance;Plague;Poly-fluoroalkyl substances;Pregnancy;Pregnant Women;prenatal;prenatal exposure;Preschool Child;Process;prospective;Prospective cohort;Public Health;Reporting;Sampling;School-Age Population;Serum;sex;Sleep;Sleep Disorders;Sleep disturbances;sleep health;sleep quality;Statistical Methods;Syndrome;Time;virtual

PROJECT_TITLE: Relationship between prenatal maternal PFAS exposure and child sleep outcomes

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Asthma;Climate-Related Exposures and Conditions;Clinical Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Pediatric;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative  Our project focuses on the respiratory health of young Mexican American adults living in an agricultural community for whom we have collected extensive information since their mothers were pregnant. In this grant, we will assess exposure to agricultural pesticides and particulate matter air pollution from pregnancy through 22 years of age and determine how these exposures work together to effect respiratory health in early adulthood.

PI_NAMEs: GUNIER, ROBERT  (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: 21 year old;7 year old;Absenteeism;Address;Adolescence;Adult;Age;Age Years;agricultural community;agricultural pesticide;Agriculture;Air;air monitoring;Air Pollutants;Air Pollution;Airway Disease;airway inflammation;Asthma;Biological;Biological Markers;Birth;California;Cells;Child;Childhood;Childhood Asthma;cohort;Cohort Studies;Complex;cost;Cross-Sectional Studies;Data;Data Reporting;design;Disease;DNA;DNA Methylation;early life exposure;emerging adult;Environment;Environmental Exposure;epigenetic marker;Epigenetic Process;Epithelial Cells;Ethylenes;Etiology;Exposure to;Family;farm worker;fine particles;fungicide;Future;Genes;Goals;Grant;Growth;health assessment;Hypersensitivity;Individual;Inflammation;Joints;Life;Link;Longitudinal Studies;Measures;Methylation;methylome;Mexican Americans;Morbidity - disease rate;mortality;Mothers;Nasal Epithelium;nasal swab;Nose;novel;Occupational;Occupational Exposure;Organophosphates;Outcome;Participant;Particulate Matter;Pathway interactions;Persons;pesticide exposure;Pesticides;Play;Policies;pollutant;potential biomarker;Predisposition;Pregnancy;pregnant;prenatal;prospective;Prospective Studies;pulmonary function;Pulmonary function tests;Quality of life;remote sensing;Research;Respiratory Disease;respiratory health;Respiratory Signs and Symptoms;response;Risk;Role;Salinas Valley;Schools;Site;Societies;Spirometry;Structure of mucous membrane of nose;Study of Latinos;Sulfur;Symptoms;Testing;Tissues;urban area;Visit;Work;young adult

PROJECT_TITLE: Prenatal and lifetime exposure to pesticides and particulate matter and respiratory health in young adults from the CHAMACOS birth

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Diabetes;Genetics;Human Genome;Obesity

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Public Health Relevance Statement (Project Narrative) In order to better understand the composition of human white adipose tissue, we performed single nucleus RNA sequencing, which allowed us to collect information about individual cell types within this complex tissue. We found several distinct types of adipocytes, some of which are associated with body weight and risk of type 2 diabetes (T2D). Here we will identify which factors predispose to the development of one adipocyte type over another, with the goal of finding targets for treatments that can ameliorate metabolic diseases like T2D.

PI_NAMEs: EMONT, MARGO PREMINGER (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Adipocytes;Adipose tissue;Atlases;bariatric surgery;Biological Assay;blood glucose regulation;Body mass index;Body Weight;Body Weight decreased;Cell Culture Techniques;Cell Nucleus;cell type;Cells;Chromatin;Communities;Complex;CRISPR-mediated transcriptional activation;Data;Data Correlations;Data Set;Development;differential expression;energy balance;experience;experimental study;Genetic;genetic association;Genetic Transcription;genome wide association study;Goals;Heterogeneity;high body mass index;Human;In Vitro;Individual;Insulin Resistance;insulin sensitivity;Knowledge;Lipids;Measurement;Mentors;Metabolic;metabolic abnormality assessment;Metabolic Diseases;metabolic phenotype;Modeling;Non-Insulin-Dependent Diabetes Mellitus;obese person;Population;Positioning Attribute;Predisposing Factor;Prevalence;public health relevance;Publishing;Regulation;Regulatory Element;Resolution;Risk;Sampling;Signal Transduction;single nucleus RNA-sequencing;subcutaneous;Testing;Thinness;Time;Tissues;trait;transcription factor;Transposase;Validation;Visceral;Work

PROJECT_TITLE: Investigating the regulation of distinct human adipocyte subpopulations


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Estrogen;Genetics;Neurodegenerative;Neurosciences;Women's Health Research

ORG_CITY: PORTLAND

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Currently, there are over 5.7 million Alzheimer’s disease (AD) patients in the United States, and nearly two-thirds of the AD patients are postmenopausal women who have lost the neuroprotective effects of estrogens. We have synthesized and characterized a non-steroidal estrogenic ligand, STX that selectively targets the CNS and is neuroprotective against amyloid toxicity in a mouse model of AD. In the proposed studies we will isolate the STX receptor using photo-crosslinking and click chemistries and confirm its identity via in vivo CRISPR mutagenesis studies, which will augment the development of STX as a novel therapeutic for treating postmenopausal women and AD.

PI_NAMEs: KELLY, MARTIN JEFFREY (contact);SCHULTZ, CARSTEN

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: Academy;Acceleration;adeno-associated viral vector;Alkynes;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;American;Amyloid;Amyloid beta-Protein;Azides;Biological;blood-brain barrier crossing;Brain;Breast Cancer Risk Factor;Calcium Signaling;candidate identification;Cells;Central Nervous System;Chemistry;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Conjugated Estrogens;Core Facility;Coupled;CRISPR/Cas technology;crosslink;Data;Dementia;design;Development;Diazomethane;effective therapy;Electrophysiology (science);Endocrinologist;Estradiol;Estrogen Nuclear Receptor;Estrogen Receptors;estrogenic;Estrogens;Event;Exhibits;experimental study;fluorophore;Gene Deletion;Goals;Guide RNA;Hippocampus;Hormone replacement therapy;Hypothalamic structure;improved;In Vitro;in vivo;Isomerism;knock-down;Label;Ligands;Measures;Membrane;Mitochondria;Molecular;mouse model;mRNA Expression;Mus;Mutagenesis;Neurology;neuron loss;Neurons;neuroprotection;nonhuman primate;novel;novel therapeutics;Oral;Oral Administration;pharmacologic;Physiological;Postmenopause;prevent;Pro-Opiomelanocortin;Process;Proteins;Proteomics;receptor;Receptor Activation;recombinase;Recommendation;Research;response;Reverse Transcriptase Polymerase Chain Reaction;Rodent;Selective Estrogen Receptor Modulators;Senile Plaques;Shiga Toxin;side effect;Signal Pathway;Signal Transduction;Slice;Small Interfering RNA;Staphylococcus aureus;Structure of nucleus infundibularis hypothalami;Synaptic Transmission;Therapeutic;thrombotic;Toxic effect;United States;Virus;Woman

PROJECT_TITLE: Identification of the Neuroprotective STX Receptor in the Brain

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Hematology;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Antiphospholipid syndrome (APS) is a leading cause of blood clotting and is triggered by abnormal antibodies that activate immune cells and thereby damage blood vessels. This proposal investigates a natural mechanism by which enzymes convert harmful molecules released from dying cells into a substance called adenosine that protects blood vessels from inflammation. The goal of this work is to harness these protective pathways to protect against the devastating effects of APS in patients.

PI_NAMEs: KNIGHT, JASON  (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Adenosine;Adjuvant;ADORA2A gene;Agonist;Animal Model;Anti-Inflammatory Agents;Anti-phospholipid Syndrome;Antibodies;Anticoagulants;Anticoagulation;Antiphospholipid Antibodies;Area;Autoimmune;Bioenergetics;Blood coagulation;blood damage;Blood Platelets;Blood Vessels;Cell Respiration;Cell Surface Receptors;Cells;Chromatin;Chronic;Clinic;Clinical;Coagulation Process;cohort;combat;Communication;COVID-19;Cyclic AMP;Cyclic AMP Receptors;Cyclic AMP-Dependent Protein Kinases;Data;Deterioration;dietary;dietary manipulation;Disease;disease phenotype;drug candidate;ecto-nucleotidase;Enzymes;Event;experience;experimental study;extracellular;Functional disorder;Glucose;glucose metabolism;Glycogen;Goals;Grant;Homeostasis;Hyperactivity;Immune;immunothrombosis;In Vitro;Inflammation;Intervention;Knockout Mice;Lupus;Mass Spectrum Analysis;Measurement;Mediating;Metabolic;Metabolism;microbicide;Modeling;Mus;Myelogenous;Neurofibrillary Tangles;neutrophil;Neutrophil Activation;Organ;Patients;Pentosephosphate Pathway;Phenotype;Phosphorylation;platelet function;Play;Pregnancy loss;protective pathway;Proteins;Purine Nucleotides;Purinergic P1 Receptors;receptor;Research Personnel;Resistance;restraint;Role;Signal Transduction;Surface;System;Therapeutic;Thrombosis;thrombotic;Time;Work

PROJECT_TITLE: Purinergic modulation of the autoimmune vascular phenotype

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: HOSPITAL FOR SICK CHLDRN (TORONTO)

ORG_STATE: ON

ORG_ZIPCODE: M5G 1X8

PHR: PROJECT NARRATIVE Autism Spectrum Disorder (ASD) affects 1 in 44 children, but our understanding of the genetics of ASD remains limited. This project aims to understand how newly discovered small proteins (miniproteins) contribute to the genetic etiology of ASD. The results of this study will provide a critical infrastructure for inclusion of miniprotein genes in complex trait genetic analyses and will identify new targets for mechanistic study in the neurobiology of ASD.

PI_NAMEs: KALISH, BRIAN  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Address;Affect;Amino Acids;Atlases;autism spectrum disorder;Base Sequence;Bioinformatics;Biology;Brain;brain tissue;Calcium Signaling;Cell Differentiation process;cell type;Child;Clinical;Code;cohort;Collection;Complex Genetic Trait;computational pipelines;Computer Models;Data;Data Set;de novo mutation;Development;Disease;disorder risk;dosage;Etiology;experimental study;Family;Foundations;Future;Genes;Genetic;genetic analysis;genetic architecture;Genetic Diseases;Genetic Predisposition to Disease;genetic variant;Genome;genome annotation;genome sequencing;genome wide association study;Genomics;Goals;Grant;Heritability;Human;human disease;Impairment;Individual;Infrastructure;Inherited;insertion/deletion mutation;interest;Investigation;Knowledge;large datasets;life span;mitochondrial metabolism;Modeling;Molecular;mRNA Translation;Nervous System;Neurobiology;Neurodevelopmental Disorder;Neurologic;Neurons;neuropsychiatric disorder;Neurosciences;novel;Nucleotides;Open Reading Frames;Phenotype;polygenic risk score;programs;Protein Analysis;Protein Truncation;Proteins;Regulation;repetitive behavior;Research;research clinical testing;ribosome profiling;RNA Binding;Role;social communication;Social Interaction;Specificity;three dimensional structure;trait;Translating;Translations;translatome;transmission process;Twin Studies;United States;Untranslated RNA;Variant;whole genome;Work

PROJECT_TITLE: Discovery of Novel Autism-Associated Variation in Brain Miniproteins

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Methamphetamine;Neurodegenerative;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: Public Health Relevance The molecular mechanisms responsible for neuropsychological impairment in HIV patients are not easily inferred with conventional high-throughput analysis methods. To investigate the molecular mechanisms behind the interactions of HIV and methamphetamine (METH), this interdisciplinary project will profile gene expression at the single cell level in key brain regions relevant to the effects of persistent HIV infection and substance use disorder (SUD) in a small animal model of neuroHIV in a behavioral paradigm of voluntary intravenous METH self-administration. We will bring to bear computational methods to elucidate the genes (master regulator genes) driving the altered gene expression, which will provide a framework for new testable hypotheses on the mechanisms underlying the neuropathogenesis of the increased neuroinflammation, neurodegeneration and compulsivity to take METH in the context of METH abuse that can be targeted therapeutically to improve neuropsychological functioning in people with HIV.

PI_NAMEs: SANNA, PIETRO P (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Address;Adopted;Alzheimer's Disease;Animal Model;Astrocytes;Automobile Driving;Behavior;Behavioral Paradigm;Binding;Brain region;Cell Nucleus;cell type;Cells;Central Nervous System;Chronic;Clinical;comorbidity;Computing Methodologies;Data;Data Coordinating Center;Development;Disease;Disease Progression;Drug Addiction;drug mechanism;Drug usage;DSM-IV;experience;Freezing;Gene Expression;gene network;gene regulatory network;Genes;genetic signature;genome-wide;Genomics;Goals;Head;high throughput analysis;HIV;HIV Infections;HIV-1;Human;Impairment;improved;Intake;Intravenous;Lymphocyte;Macrophage;Malignant Neoplasms;Methamphetamine;methamphetamine abuse;methamphetamine effect;methamphetamine use;Methamphetamine use disorder;Methods;Microglia;Modeling;Molecular;Nerve Degeneration;nerve injury;neural;neuroAIDS;neuroinflammation;Neurons;Neuropathogenesis;Neuropsychology;Neurosciences;new therapeutic target;novel;novel therapeutics;Pathogenicity;Pathway Analysis;Patients;Pattern;Persons;Pharmaceutical Preparations;Proteins;public health relevance;Rat Transgene;Rattus;reconstruction;Recording of previous events;Recreation;Regulation;Regulator Genes;Research Personnel;Resolution;Resources;Rodent Model;Sampling;Self Administration;single cell analysis;single nucleus RNA-sequencing;stimulant abuse;Substance Use Disorder;Synapses;Systems Biology;targeted treatment;Testing;Therapeutic;therapeutic target;Tissues;Transcript;transcriptomics;Transgenes;Transgenic Organisms;Validation;validation studies;Virus

PROJECT_TITLE: Single nucleus gene expression in moderate and compulsive drug self-administration in a rodent model of HIV


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: RELEVANCE Black Americans are at nearly twice the risk for Alzheimer’s disease and Related dementias (ADRD) compared to non-Hispanic White Americans; yet they are underrepresented in research. As a result, our scientific understanding of ADRD may not generalize to Black populations. This project will investigate the prevailing theory of Alzheimer’s disease, the Amyloid hypothesis, testing if it holds up in a group of Black participants, and we will also examine recruitment and retention strategies using a scientific approach to understand what works and why.

PI_NAMEs: GLEASON, CAREY E (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: abeta accumulation;abeta deposition;Acceleration;Address;Adult;Affect;African American population;Age;Age of Onset;age related;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid;Amyloid beta-Protein;Amyloidosis;archived data;Area;Belief;Biological Markers;Black American;black patient;Black Populations;Black race;caucasian American;Cerebrovascular Disorders;Cerebrum;Chronic;Clinical;Clinical Research;Cognition;Cognitive;cohort;Collection;Data;Data Set;Diabetes Mellitus;Disclosure;Disease;disease model;Disparity;Emotions;Enrollment;Event;Family history of;fighting;Functional disorder;Goals;health disparity;Impaired cognition;Impairment;improved;Individual;International;Investments;Link;Longitudinal cohort;Meta-Analysis;Metabolic Diseases;Methods;middle age;Minority Groups;Mission;Modeling;Not Hispanic or Latino;Participant;Pathologic;patient engagement;Pattern;pattern perception;perceived discrimination;Perception;PET positivity;Plasma;Population;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;Predictive Factor;predictive modeling;processing speed;prognostic value;programs;prospective;psychosocial;Psychosocial Factor;Race;recruit;Research;retention rate;Risk;ROC Curve;Role;Sampling;Sleep;Stressful Event;success;symposium;tau Proteins;Testing;theories;Time;Trust;United States National Institutes of Health;vascular risk factor;Visit;Work

PROJECT_TITLE: African Americans Fighting Alzheimer’s in Midlife (AA-FAIM)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(55)R]