ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE  Despite development of reperfusion therapies, many patients still experience considerable neurological disability following ischemic stroke, which indicates a critical need for neuroprotective treatments that can improve post-stroke functional outcomes in the setting of recanalization. In this grant renewal application, we will demonstrate that neuroprotective effectiveness of 3-hydroxy-3-methyllutaryl coenzyme A (HMG-CoA) reductase inhibitors (i.e., statins) is dependent upon functional expression of organic anion transporting polypeptide 1a4 (Oatp1a4), an endogenous uptake transporter expressed at the blood-brain barrier (BBB). Our work will directly impact public health in the United States by informing development of novel treatment paradigms for stroke by showing that transporter-mediated drug delivery is a critical mechanism that enables neuroprotective drugs to achieve efficacious concentrations in the ischemic brain.

PI_NAMEs: RONALDSON, PATRICK THOMAS (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Activin Receptor;activin receptor-like kinase 1;Age;Agonist;Alteplase;Animal Model;Animals;antagonist;Apoptosis;atorvastatin;Autophagocytosis;Biological Markers;Blood;Blood - brain barrier anatomy;Blood Vessels;bone morphogenetic protein 9;Brain;brain endothelial cell;Brain Ischemia;Central Nervous System;Central Nervous System Agents;Clinic;clinically relevant;Coenzyme A;Data;Development;Disabilities experience;disability;Dose;Drug Delivery Systems;drug discovery;Effectiveness;endovascular thrombectomy;experience;experimental study;Female;functional outcomes;Goals;Grant;Hypoxia;improved;in vivo;in vivo Model;Incidence;indexing;inhibitor;Injections;Intervention;Intravenous;intravenous administration;Ischemic Stroke;Laboratories;male;Measures;Mediating;Middle Cerebral Artery Occlusion;Modeling;Motor;Necrosis;Neurocognitive;Neurologic;Neurological disability;Neurological outcome;neuroprotection;Neuroprotective Agents;novel;novel therapeutics;OATP Transporters;Organic Anion Transporters;Oxidative Stress;Oxidoreductase;Patients;Performance;Pharmaceutical Preparations;Pharmacotherapy;Phase III Clinical Trials;post stroke;Pravastatin;pre-clinical;preclinical study;Process;Public Health;Publishing;Rattus;receptor;Reperfusion Therapy;response;Rodent;Role;Signal Transduction;Smad Proteins;Sprague-Dawley Rats;Stress;Stroke;stroke model;stroke outcome;stroke patient;stroke recovery;stroke therapy;Tail;Testing;TGF Beta Signaling Pathway;TGF-beta type I receptor;Therapeutic;therapeutic effectiveness;thrombolysis;Thrombolytic Therapy;Time;Transforming Growth Factor beta;Transforming Growth Factors;Translating;treatment strategy;United States;uptake;Vascular Endothelium;Veins;Work

PROJECT_TITLE: Targeting Blood-Brain Barrier Transporters to Treat Ischemic Stroke


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biomedical Imaging;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: DURHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because cardiovascular disease is a dire health concern for rural dwelling adults in the US who are among the most resource-limited. As a consequence of the work proposed, we expect to identify the determinants of differences in cardiac structure and function in rural America and their relationship to subclinical cardiovascular disease, considering a broad view of the determinants of health. The project is relevant to the part of the NIH’s and NHLBI’s missions that pertain to scientific inquiry to improve health in rural America and reduce health disparities.

PI_NAMEs: BLOOMFIELD, GERALD SAMUEL (contact);DOUGLAS, PAMELA SUSAN

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Adult;Age;American;Ancillary Study;Appalachian Region;Artificial Intelligence;Biological;Biological Factors;Blood;burden of illness;Cardiac;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Characteristics;Clinic;Clinical;cohort;Collaborations;Communities;comorbidity;Companions;cost effective;County;Data;Data Set;Death Rate;Dedications;Development;Diabetes Mellitus;Disease;Disparity;Echocardiography;Ensure;Environmental Risk Factor;Epidemiologic Factors;epidemiology study;Evaluation;experience;Family history of;Frequencies;Functional disorder;Funding;Geometry;Goals;Health;health determinants;health equity;Heart;Heart Abnormalities;Heart Diseases;Heart failure;heart imaging;Hematological Disease;High Prevalence;high risk;Hypertension;Image;imaging biomarker;Imaging Device;improved;improved outcome;Incidence Study;Individual;Individual Differences;industry partner;Infrastructure;insight;Intervention;Knowledge;Laboratories;Left Ventricular Hypertrophy;Life;life span;Longitudinal cohort;Longitudinal cohort study;Longitudinal Studies;Lung;Lung Diseases;Measures;Mediating;Mediation;Medical History;Methodology;Mission;Mississippi;Modification;Monitor;Morbidity - disease rate;mortality;Motion;multi-ethnic;Myocardial Infarction;Names;National Heart, Lung, and Blood Institute;Neighborhoods;novel;Obesity;Parents;Participant;Pathway interactions;Phenotype;Population;Poverty Areas;premature;Prevalence;prognostic;progression risk;Public Health;quality assurance;Race;Reduce health disparities;Research;Research Personnel;Resources;response;Risk;Risk Factors;Rural;rural America;Rural Appalachia;rural area;Rural Community;rural dwellers;rural residence;rural setting;Scientific Inquiry;Scientist;sex;Sleep;Sleep Disorders;Smoking History;social;social factors;social health determinants;Statistical Methods;Stress;Stroke;Structure;Symptoms;Testing;tool;transmission process;United States National Institutes of Health;Vascular Diseases;Work;X-Ray Computed Tomography

PROJECT_TITLE: Epidemiologic Determinants of Cardiac Structure and Function in Rural Residents: RURAL ECHO

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Extracellular matrix homeostasis and its dysregulation that occurs in the trabecular meshvvork tissues of glaucomatous eyes is complicated, and an area of intense research. The role of actively released exosomes in these processes is largely unknown. Due to the natural flow patterns of aqueous humor through the trabecular meshwork tissues, exosomes represent ideal platforms to participate in conventional outflow regulation through the maintenance of extracellular matrix homeostasis.

PI_NAMEs: MCDONNELL, FIONA  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Anterior;Aqueous Humor;Area;Binding;Biology;cell type;Cells;Cellular biology;Cornea;Cytoskeleton;Data;design;differential expression;Disease;Elements;Environment;Equilibrium;ex vivo perfusion;exosome;Experimental Designs;Exposure to;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;extracellular vesicles;Eye;Feedback;Fibroblasts;Fibronectins;Fibrosis;Flow Cytometry;Functional disorder;Gene Expression;Genes;Glaucoma;Homeostasis;Human;Immunofluorescence Immunologic;In Situ;In Vitro;Integrins;intercellular communication;Interruption;kinase inhibitor;Label;Maintenance;Malignant Neoplasms;Matrix Metalloproteinases;Mechanics;Mediating;Mentors;Methods;MicroRNAs;Monitor;nanosized;nanovesicle;natural flow;novel;Ocular Hypertension;optic nerve disorder;Organ Culture Techniques;Outcomes Research;Pathway interactions;Pattern;Perfusion;Phase;Phenotype;Physiologic Intraocular Pressure;Process;Production;Proteomics;Regulation;Rejuvenation;repaired;Research;Resistance;Rho-associated kinase;Risk Factors;Role;skills;Stretching;Techniques;theories;Therapeutic;Tissues;Trabecular meshwork structure;Tracer;Training;Waste Management

PROJECT_TITLE: Exosomes and Conventional Outflow Homeostasis

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Clinical Research;Neurodegenerative;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: BLOOMINGTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE American football players can experience hundreds of mild “subconcussive” head hits annually from football tackles. The teenage brain responds more adversely to these hits than does the adult brain, leading to an increased risk for development of a brain disorder in later life. We will aim to address whether, and to what extent, repetitive subconcussive head impacts during a high school football career negatively impact brain health and, ultimately, to establish safety guidelines for head impact exposure.

PI_NAMEs: KAWATA, KEISUKE  (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acute;Address;Adolescence;Adolescent;Adult;American;Autoimmune Responses;Awareness;Axon;axon injury;biobehavior;Biological Markers;Blood;Brain;brain cell;Brain Concussion;Brain Diseases;brain health;career;catalyst;Chronic;Clinical;Clinical Research;concussive symptom;contact sports;Corpus Callosum;Data;Development;Dose;evidence based guidelines;Exhibits;exosome;experience;Exposure to;Eye;Functional Magnetic Resonance Imaging;gaze;glial activation;Glial Fibrillary Acidic Protein;Goals;Guidelines;Head;head impact;Health;high school;Ice Hockey;Image;Impairment;innovation;kinematics;late life;Light;Limbic System;Long-Term Effects;Longitudinal Studies;Manufactured football;Measures;mechanical force;Microglia;Molecular;motor impairment;multimodality;Nerve Degeneration;neural;Neurocognitive Deficit;neurodevelopment;neurofilament;Neuroglia;neuroimaging;neuroinflammation;Neurologic;Neurons;oculomotor;Participant;Pathologic;Performance;Physiological;Play;Positioning Attribute;Prefrontal Cortex;prevent;progressive neurodegeneration;Prospective Studies;Proteomics;Protocols documentation;Public Health;Recording of previous events;Research;Research Personnel;response;Rest;Risk;Safety;Seasons;sensor;Sensory;Serum;Signs and Symptoms;Site;Soccer;Speed;Sports;Structure;subconcussion;synaptic pruning;tau Proteins;Teenagers;Testing;Time;ubiquitin C-terminal hydrolase;United States;white matter;white matter change;Work

PROJECT_TITLE: Subconcussive neurodegenerative progression in adolescent athletes

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The kidney is one of the two organs in the body that can synthesize new glucose via gluconeogenesis, but the impact of this process in renal cell carcinoma (the most common form of kidney cancer) is not known. This proposal will test whether and how a metabolic stress signal, fibroblast growth factor-21 (FGF-21), drives renal cell carcinoma via increasing rates of renal gluconeogenesis. This study will utilize a unique complement of genetic and pharmacologic models and tracer analysis to document kidney-specific gluconeogenesis rates in awake mice with kidney cancer, and link alterations in renal glucose production to renal cell carcinoma progression for the first time, thereby potential identifying FGF-21 as a potential therapeutic target for kidney cancer.

PI_NAMEs: PERRY, RACHEL JAMISON (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Acceleration;Acetyl Coenzyme A;Adrenergic Agents;Adrenergic Receptor;Affect;Automobile Driving;awake;Cessation of life;Chronic;Chronic Kidney Failure;clinical development;clinical investigation;Clinical Trials;Complement;Data;Diabetes Mellitus;Dwarfism;Enzymes;fibroblast growth factor 21;Genetic;genetic approach;Genetic Predisposition to Disease;Gluconeogenesis;Glucose;glucose metabolism;glucose production;glucose uptake;Glycolysis;Homeobox;Human;Impairment;in vivo;Infusion procedures;inhibitor;Kidney;Kidney Neoplasms;Link;Lipolysis;Liver;Measures;Metabolic;Metabolic stress;Metabolism;Methodology;Methods;Modeling;mouse model;Mus;neutralizing antibody;novel;Obesity;Organ;oxidation;Pathogenesis;Pathway interactions;pharmacologic;Pilot Projects;Process;Prognosis;Proteins;Pyruvate Carboxylase;Rattus;Regulation;Renal Adenoma;Renal Carcinoma;Renal Cell Carcinoma;Research Personnel;Risk;Rodent;Role;Signal Transduction;Starvation;Techniques;Testing;therapeutic target;Time;Tissues;Tracer;tumor;tumor growth;Tumor Markers;tumor metabolism;tumor progression;Tumor Promotion;United States

PROJECT_TITLE: Defining the Role of Renal Gluconeogenesis in Renal Cell Carcinoma

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Data Science;Digestive Diseases;Eczema / Atopic Dermatitis;Food Allergies;Genetics;Human Genome;Nutrition;Pediatric;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Food allergy and atopic dermatitis are common allergic conditions affecting 10% and 20% of children, respectively. Systems Biology of Early Atopy (SunBEAm) is a general population pre-birth cohort study initiated by the NIH to study the role and inter-relationships of genetic, clinical, biological, and environmental early-life factors in the development of allergic diseases, with an emphasis on FA and AD. The SunBEAm Analysis & Bioinformatics Center will assay SunBEAm biosamples using high dimensional profiling and apply integrative systems biology to identify novel determinants of FA and AD.

PI_NAMEs: BUNYAVANICH, SUPINDA  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Adult;Affect;Allergic;Allergic Disease;Anaphylaxis;Angioneurotic Edema;Area;Atopic Dermatitis;atopy;Award;biobank;Bioinformatics;Biological;Biological Assay;biological heterogeneity;Biological Markers;biological systems;Biology;Birth;Cardiovascular system;Child;Chronic;Clinical;Clinical Management;cohort;Cohort Studies;Collection;Communication;Complex;Computational Biology;Data;data integration;Data Science;design;Development;Diagnosis;Dimensions;Disease;Distress;Emotional;Enrollment;Ensure;expectation;experience;Fathers;Food;food antigen;Food Hypersensitivity;Funding;Future;gastrointestinal;General Population;Genetic;Genome;Goals;Health;high dimensionality;Hypersensitivity;Immune;Immunologist;Impairment;improved;Individual;Infrastructure;Ingestion;innovation;Intervention;Knowledge;Life;lipidome;machine learning model;metabolome;microbiome;Molecular;multiple omics;multiscale data;National Institute of Allergy and Infectious Disease;novel;novel marker;nutrition;Participant;Phenotype;Physicians;Policies;Pregnant Women;Prevention;Procedures;Proteome;Quality of life;Research;Research Activity;Research Personnel;respiratory;Risk;Risk Factors;risk sharing;Role;Scientist;Skin;success;Symptoms;System;Systems Biology;Technology;Time;tool;transcriptome;United States National Institutes of Health;Urticaria;Visualization;whole genome

PROJECT_TITLE: Systems Biology of Early Atopy (SUNBEAM) Analysis and Bioinformatics Center


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Patient Safety;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project narrative The proposed research will apply principles of clinical pharmacology in order to better define the therapeutic window and optimal use of three drugs used in the treatment of mycobacterial infections. This project aims to establish the bactericidal kinetics of standard of care for Mycobacterium avium complex lung disease, define the pharmacokinetics (PK)-toxicodynamic (TD) relationships for a novel nitroimidazole antibiotic, and describe the magnitude of drug-drug interaction between first-line tuberculosis treatment and a promising agent for adjunctive host-directed therapy. The knowledge gained by this proposal through these diverse yet complementary aims will strengthen the science of tuberculosis and nontuberculous mycobacteria therapeutics.

PI_NAMEs: IGNATIUS, ELISA HELEN (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Adverse event;Advisory Committees;analytical method;Antibiotics;Antimycobacterial Agents;Area;Azithromycin;bactericide;Bronchiectasis;Cessation of life;Clinical;Clinical Investigator;Clinical Pharmacology;Clinical Trials;Collaborations;Colony-forming units;Combined Antibiotics;Combined Modality Therapy;Committee Members;Communicable Diseases;Companions;Complex;Country;Data;design;Development;Disease;Dose;drug biological activity;drug development;Drug Exposure;Drug Interactions;Drug Kinetics;Drug resistance;Drug toxicity;Drug usage;drug-sensitive;Enzymes;Evaluation;Funding;Future;Goals;Hepatotoxicity;high risk;Immune response;improved;in vivo;Incidence;Institution;Investigation;Kinetics;Knowledge;Lead;Learning;Licensing;Lung;Lung Diseases;lung injury;Medical;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;minimal inhibitory concentration;Modeling;multidisciplinary;mycobacterial;Mycobacterium avium Complex;Mycobacterium Infections;New Agents;Nitroimidazoles;non-tuberculosis mycobacteria;novel;novel therapeutics;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetic model;pharmacologic;Pharmacology;pharmacometrics;Pharmacotherapy;Phase;Physicians;Population;Positioning Attribute;Pravastatin;Pre-Clinical Model;predictive tools;Research;Research Personnel;Resources;response;Rifabutin;Rifampin;Science;Scientist;screening;Serum;skill acquisition;skills;Sputum;standard care;standard of care;success;Therapeutic;Time;tool;Toxic effect;Training;treatment effect;trial design;trial enrollment;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Writing

PROJECT_TITLE: Optimizing Anti-mycobacterial Therapy Using A Pharmacology-based Approach

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

PHR: Project Narrative Identifying where tuberculosis transmission occurs is an urgent priority for tuberculosis control programs. Yet current genomic epidemiology approaches for inferring transmission linkages have limited resolution because they sequence a single M. tuberculosis genome from each infected individual. We propose to develop sequencing and transmission inference approaches to recover the M. tuberculosis diversity within infected individuals and harness this diversity to reconstruct transmission linkages in a high-incidence setting.

PI_NAMEs: WALTER, KATHARINE SASSANDRA (contact)

PROJECT_TERMS: Bioinformatics;Brazil;burden of illness;career;Clinical;Clinical Trials;clinically significant;Collaborations;Communicable Diseases;Consensus;Consensus Sequence;deep sequencing;Development;Diagnosis;disease transmission;diverse data;Drug resistance;Enrollment;Epidemic;epidemiological model;Epidemiology;epidemiology study;Event;Evolution;experience;Faculty;Foundations;Funding;Future;Genetic;Genetic Models;Genome;genomic data;genomic epidemiology;genomic tools;genomic variation;Genomics;Genotype;Hybrids;Incidence;Individual;Infection;information model;innovation;Interruption;K-Series Research Career Programs;Link;Location;M. tuberculosis genome;mathematical model;Mathematics;Measures;medical schools;Medicine;Mentors;Methods;microbial disease;mid-career faculty;Minority;Modeling;Molecular Epidemiology;Mycobacterium tuberculosis;novel;novel strategies;Participant;pathogen;Pattern;Phylogenetic Analysis;Physicians;Population;Population Genetics;Positioning Attribute;Prisons;professor;programs;prospective;Prospective cohort;Public Health Schools;Recovery;reference genome;Reference Standards;Reporting;Reproducibility;Research;Research Proposals;Resolution;Resource-limited setting;Risk;Sampling;Scientist;screening;secondary infection;skill acquisition;Sputum;Statistical Data Interpretation;surveillance data;Time;tool;Training;transmission process;Treatment outcome;Trees;Tropical Disease;Tuberculosis;United States National Institutes of Health;Universities;Variant;Visualization;Writing

PROJECT_TITLE: Leveraging within-host M. tuberculosis diversity data to enhance transmission inference

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SYRACUSE

ORG_NAME: SYRACUSE VA  MEDICAL CENTER

PHR: Primary Care Brief Mindfulness Training (PCBMT) consists of group mindfulness classes designed to be delivered in primary care to Veterans with psychological distress. Many Veterans who are not willing to engage in traditional mental health treatment are willing to take classes to learn skills they can apply in their daily life to manage distress. Earlier research has indicated that Veterans like these classes and that they are associated with reduced mental health symptoms. The current study seeks to test PCBMT in three VA sites to further investigate its effectiveness in helping Veterans reduce psychological distress. Results of this study have the potential to create a new treatment option for Veterans and improve Veteran mental health.

PI_NAMEs: POSSEMATO, KYLE  (contact)

PROJECT_TERMS: active control;alternative treatment;Anxiety;biological adaptation to stress;Clinical;Clinical Trials;clinically significant;cognitive reappraisal;cost;design;Diagnostic;Distress;educational atmosphere;Educational process of instructing;Effectiveness;effectiveness testing;effectiveness/implementation trial;emotion regulation;Equity;evidence base;experience;flexibility;future implementation;Geography;health administration;Health Personnel;Housing;Hybrids;implementation barriers;implementation determinants;implementation efforts;implementation evaluation;implementation facilitators;improved;Intervention Studies;Interview;Learning;Learning Skill;Life;Location;Mediating;Mediator;Meditation;Mental Depression;Mental Health;Mental Health Services;Mental Processes;military veteran;mindfulness;mindfulness intervention;Mindfulness Training;mindfulness-based stress reduction;Modality;Moods;Outcome;Participant;Pathologic;Patient Preferences;peer;Pharmaceutical Preparations;Phase;Post-Traumatic Stress Disorders;preference;Primary Care;primary care clinic;primary care patient;primary care setting;Problem Solving;Process;programs;Provider;psychoeducation;psychologic;psychological distress;Psychotherapy;Race;Randomized;Randomized, Controlled Trials;Reporting;Research;Scanning;self reliance;Series;Severities;sex;Site;skills;social health determinants;social stigma;Specialist;Stigmatization;Stressful Event;Symptoms;Testing;traditional therapy;Training;Training Programs;Trauma;treatment as usual;Treatment Step;Veterans;Voice;whole health;willingness;Work;Yoga

PROJECT_TITLE: Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Buprenorphine and other medications for opioid use disorder are standard of care for the treatment of opioid use disorder, and utilization is linked with substantial reductions in the risk of negative outcomes, including overdose and death. Research has shown that longer periods in treatment (>12 months) yield the greatest benefit, yet more than half of patients will discontinue before 12 months. The goal of this study is to understand why early buprenorphine discontinuation takes place, and identify modifiable factors at the patient, provider and system-level that contribute. Ultimately this study will help to inform interventions designed to improve retention in treatment for Veterans with opioid use disorder.

PI_NAMEs: WYSE, JESSICA JASMINE (contact)

PROJECT_TERMS: addiction;Address;Age;Area;barrier to care;Birth;Buprenorphine;buprenorphine treatment;care providers;Caring;Cessation of life;Clinical;Clinical Trials;Data;Data Reporting;design;Dose;Emergency department visit;Enrollment;Ensure;Ethnic Origin;experience;Face;follow-up;Foundations;Goals;Health;Health system;Hospitalization;Housing;improved;innovation;Intervention;Interview;Learning;Link;male;Medical Records;medication for opioid use disorder;Methodology;Methods;Morbidity - disease rate;mortality;Motivation;novel;Observational Study;Opioid;opioid mortality;opioid overdose;opioid use disorder;Outcome;Overdose;Pain interference;participant enrollment;Patient Preferences;patient retention;Patient-Focused Outcomes;Patients;perceived discrimination;Perception;Personal Satisfaction;Pharmaceutical Preparations;Play;polysubstance use;Predictive Factor;Process;Prospective, cohort study;Provider;provider factors;Race;racial minority;Recommendation;Records;Relapse;relapse risk;Research;Resources;Risk;Risk Reduction;Role;Rural;rurality;Sampling;sex;shared decision making;social;social stigma;standard of care;substance use;Suicide;Surveys;System;therapy design;therapy development;Transportation;transportation access;Trust;urban residence;Veterans;Woman

PROJECT_TITLE: Predictors and Processes of Early Buprenorphine Discontinuation

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: Nashville

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE There is no effective medical therapy that modifies the progression of calcific aortic valve disease (CAVD), which requires an undesirable surgical intervention. We have recently discovered that targeting cadherin-11 can prevent CAVD in preclinical mouse models. We propose that cadherin-11 is a robust target for developing a novel therapy for CAVD.

PI_NAMEs: MERRYMAN, WILLIAM D (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Address;Affect;age related;Age Years;alpha Actin;aortic valve disorder;aortic valve replacement;Aortic Valve Stenosis;Biological Markers;Biology;bone;Bone Marrow Transplantation;cadherin-11;Cadherins;Cardiac;Cardiovascular Diseases;Cell Communication;Cells;Clinical;Clinical Research;Clinical Trials;clinically relevant;cohort;Development;Disease;Disease Progression;Echocardiography;Elderly;Enrollment;Future;Genetic Models;Goals;heart imaging;Heart Valve Diseases;Heterozygote;Human;human old age (65+);Immune;In Vitro;Incidence;Individual;interstitial cell;Intervention;kidney fibrosis;Measures;mechanical load;Medical;Modeling;Monoclonal Antibodies;mouse model;Mus;Myofibroblast;Nodule;novel therapeutics;older patient;Onset of illness;Operative Surgical Procedures;Pathology;Patients;Persons;pharmacologic;Physicians;Population;pre-clinical;prevent;Procedures;Quality of life;Severities;small molecule;Smooth Muscle;Testing;Therapeutic;valve replacement

PROJECT_TITLE: Cadherin-11 in calcific aortic valve disease

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pain Research;Palliative Care;Prevention;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The emerging clinical subspecialty of Neuropalliative care has grown substantially over the past several years, and Neuropalliative care research has seen its first randomized controlled trials. The Neuropalliative Care Research Symposium will bring together a diverse group of stakeholders including clinicians, researchers, and patient/family advocates from many fields and disciplines with a common interest in understanding and advancing research in Neuropalliative care and moving the field forward.

PI_NAMEs: CREUTZFELDT, CLAIRE JOHANNA (contact)

PROGRAM_OFFICER_NAME: BENSON, RICHARD T

PROJECT_TERMS: Academy;Address;Adoption;Adult;advanced directive;Advocate;Affect;Age;American;Attention;behavior change;Behavioral;Behavioral Research;Caregiver Burden;Caring;Clinical;Clinical Investigator;Clinical Research;Collaborations;Colorado;Communication;Communities;Complex;Conscious;Data Collection;Dedications;Dependence;design;Development;Diagnosis;Discipline;Discipline of Nursing;Disease;Disparity;Early identification;Education;education research;Educational workshop;end of life;end of life care;Equity;equity, diversity, and inclusion;evidence base;experience;Face;Faculty;Family;Family Caregiver;Family member;Fellowship;Fostering;Funding;Future;General Population;Geriatrics;Goals;Grief reaction;Growth;Health;health inequalities;Healthcare;Heart failure;Hospice Care;improved;Incidence;informal caregiver;Interdisciplinary Study;interest;International;Intervention;Investigation;Learning;life span;Malignant Neoplasms;Manuscripts;Mechanical ventilation;Medical;Medicine;meetings;member;Mentors;Methods;Mission;Modeling;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurologic;Neurology;next generation;non-motor symptom;Outcome Assessment;Outcomes Research;Pain;Pain management;palliative;Palliative Care;Palliative Medicine;Participant;Patient Care;patient oriented;Patient Outcomes Assessments;Patients;Peer Review;person centered;Persons;Prevalence;prevent;Prevention;Prognosis;psychologic;Psychology;psychosocial;Publications;Quality of Care;Quality of life;Race;racial disparity;racism;Randomized, Controlled Trials;Research;Research Activity;Research Design;Research Methodology;Research Personnel;research study;Role;Science;science and society;Scientific Advances and Accomplishments;social;Social Sciences;Social Work;Societies;Specialist;Spirituality;symposium;Symptoms;therapy development;Time;tool;Training;Travel;Underrepresented Minority;United States National Institutes of Health;Videotape;web site

PROJECT_TITLE: Neuropalliative Care Research Symposium

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-K (39)]


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative To establish an infection, many bacterial pathogens forage heme-iron from human hemoglobin. We will use molecular- and systems-level approaches to elucidate how this process occurs in pathogenic Corynebacterium diphtheriae and other Gram-positive bacteria.

PI_NAMEs: CLUBB, ROBERT THOMPSON (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Actinobacteria class;Affinity;Antibiotics;Bacteria;Bacterial Antibiotic Resistance;Basic Science;Bifidobacterium;Binding;Biochemical;Biochemistry;Biology;Blood;Cell Culture Techniques;Cell surface;Cell Wall;Cells;Cellular Membrane;Chemicals;cofactor;Complement 3d Receptors;Complex;Corynebacterium diphtheriae;Cytoplasm;Development;Diphtheria;Enzymes;Erythrocytes;Etiology;Excision;experimental study;extracellular;Goals;Gram-Positive Bacteria;gut microbiome;gut microbiota;haptoglobin-hemoglobin complex;Harvest;Heme;Heme Iron;heme receptor;Hemoglobin;Human;Human body;human pathogen;Infection;Infectious Skin Diseases;insight;Iron;iron protoporphyrin IX;Learning;Location;Mass Spectrum Analysis;Mediating;member;Membrane;Metabolism;Metals;Methods;Microbe;microbial;Microbiology;model organism;Molecular;Mycobacterium tuberculosis;NMR Spectroscopy;novel;novel therapeutics;Nutritional Immunity;pathogen;pathogenic bacteria;Pathogenicity;Process;protein function;Proteins;Proteomics;receptor;Reporter;Research;Research Personnel;Research Project Grants;sensor;Structural Biochemistry;structural biology;Surface;System;Testing;tool;Upper Respiratory Infections;uptake;Work;X-Ray Crystallography

PROJECT_TITLE: Molecular basis of heme scavenging by Gram-positive bacteria

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PI_NAMEs: HANCOCK, MEAGHAN H (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: 3' Untranslated Regions;Address;Adenoviruses;Affect;AKT Signaling Pathway;Apoptosis;Binding;Biochemical;Bioinformatics;Biological Assay;Bone Marrow;CD34 gene;Cell Differentiation process;Cell Proliferation;Cell Surface Receptors;Cells;Collaborations;Complement;Coupled;CREB1 gene;Cytomegalovirus;Data;Development;DNA biosynthesis;Down-Regulation;EGF gene;Engraftment;Epidermal Growth Factor Receptor;Event;experimental study;Family;Fibroblasts;Flow Cytometry;FRAP1 gene;Funding;Gene Expression;Generations;Genetic;Genetic Transcription;Goals;Growth;Growth Factor Receptors;Harvest;Hela Cells;Hematopoiesis;Hematopoietic;hematopoietic differentiation;Hematopoietic stem cells;Herpes Simplex Infections;Herpesviridae;Hour;Human;human embryonic stem cell;humanized mouse;Immunoblot Analysis;In Vitro;in vivo;Individual;Induction of Apoptosis;Infection;inhibitor;Instruction;Integrins;Kinetics;latent infection;Luciferases;Lytic Phase;lytic replication;Maintenance;MCL1 gene;Measures;Mediating;MEKs;member;MicroRNAs;Modeling;Molecular;monocyte;mouse model;Mus;mutant;Mutate;Myelogenous;Myelopoiesis;Nerve Growth Factors;Neurons;NGFR Protein;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Phosphorylation;Phosphotransferases;Play;Population;Principal Investigator;Process;programs;Proliferating;promoter;protein activation;Protein Biosynthesis;protein expression;Proteins;Proto-Oncogene Proteins c-akt;Publishing;Quantitative Reverse Transcriptase PCR;reactivation from latency;receptor;Receptor Signaling;Regulation;Reporter;Reproducibility;RNA;Role;Signal Pathway;Signal Transduction;Simplexvirus;small hairpin RNA;Standardization;stem cell homeostasis;stem cell proliferation;stem cells;Surface;Techniques;Testing;transcription factor;Transcription Factor AP-1;Transfection;Undifferentiated;Validation;Viral;Virus;Virus Activation;Virus Diseases;Virus Latency;Western Blotting;Withdrawal;Work

PROJECT_TITLE: Molecular Aspects of Cytomegalovirus Latency


ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

ORG_STATE: MA

PHR: Veterans comprise 93% of all State Veterans Home nursing home (SVH) residents. Frontline staff, such as nursing assistants, provide much of the hands-on care for these Veterans. This study is based on a program that capitalizes on the expertise of frontline staff. It uses inter-disciplinary frontline staff huddles for identifying and implementing evidence-based fall prevention interventions. The study will investigate the effectiveness of the program at reducing falls, evaluate how the program is implemented, and assess how the program is sustained once the researchers leave. This will benefit the Veterans living and staff working in the participating SVHs. It will also benefit the entire SVH system, by providing information on how this program can be spread and sustained across the system when applied to fall prevention and, potentially, other important issues.

PI_NAMEs: HARTMANN, CHRISTINE W (contact);SNOW, A LYNN

PROJECT_TERMS: Accountability;Address;Adoption;Aging;Area;Attention;Bite;burnout;Caring;Censuses;Cessation of life;Clinical;clinically significant;Collaborations;Communication;Communities;community living;Congresses;cost;COVID-19;COVID-19 pandemic;Data;Data Collection;design;Discipline of Nursing;Effectiveness;effectiveness/implementation study;Ensure;Evaluation;evidence base;Evidence based practice;Evidence based program;experience;Fall prevention;falls;Frequencies;Frontline worker;Funding;Future;Geriatrics;Government;Home;Home Nursing Care;Hospitalization;Hybrids;implementation facilitation;improved;Infection Control;Infection prevention;information gathering;Infrastructure;Injury;innovation;Inpatients;Intervention;Investigation;Job Satisfaction;Knowledge;Learning;Life Cycle Stages;Long-Term Care;Maintenance;Measures;meetings;Mental Health;Methodology;Methods;Mission;multimodality;Nursing Homes;older adult;operation;Outcome;patient safety;payment;Pharmaceutical Preparations;Policies;Population;post intervention;pragmatic trial;preventive intervention;primary outcome;Process;Program Effectiveness;Program Sustainability;programs;Quality of Care;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Relationship-Building;Replicating Effective Programs;Research;Research Personnel;Research Support;response;restraint;Role;Safety;scale up;Science;Scientific Advances and Accomplishments;Site;Spottings;Structure;success;System;theories;treatment as usual;trial design;Veterans;Vulnerable Populations;Work

PROJECT_TITLE: Pragmatic trial to increase quality of care in State Veterans Homes: Improving safety using an evidence-based, frontline staff huddling practice

STUDY_SECTION_NAME: HSR-6 Aging, Recovery, and Workforce[HSR6]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE Compared to the general population, individuals from underserved communities are more likely to receive low quality end-of-life care and unwanted, costly and burdensome treatments due in part to a lack of advance care planning (ACP; the process of discussing wishes for end-of-life care with loved ones/clinicians and documenting them in advance directives). This study will use existing, trusted, and respected social networks to evaluate two conversation-based tools intended to engage underserved individuals in discussions about end-of-life issue and motivate them to carry out ACP behaviors. Through this study we will learn how best to engage underserved populations in ACP so as to: 1) increase the likelihood that patients from underserved communities will receive high-quality end-of-life care; 2) address health disparities related to end-of-life treatments; and 3) reduce unnecessary suffering for patients and their families.

PI_NAMEs: VAN SCOY, LAUREN JODI (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Address;Advance Care Planning;advanced directive;Affect;African American;African American population;American;attentional control;Behavior;Black race;Caring;caucasian American;Cessation of life;Communication;Communities;comparative efficacy;Control Groups;cost;Data;design;distrust;Education;end of life;end of life care;Environment;Ethnic Origin;Event;evidence base;Evidence based intervention;experience;Eye;Family;Foundations;General Population;Goals;Health Benefit;Health Care Costs;health disparity;health inequalities;Health Professional;Health Resources;Healthcare Systems;Hispanic;hospice environment;implementation evaluation;improved;Individual;innovation;Intensive Care Units;Intervention;Intervention Studies;Latinx;Latinx population;Learning;loved ones;Measures;Mediator;Medical;Methods;Modeling;Negative Finding;Outcome;Participant;Patients;Performance;Placebos;Play;Population;population health;preference;prevent;primary outcome;Process;Protocols documentation;Public Health;Quality of life;Race;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Resources;Risk;Role;Science;Scientific Advances and Accomplishments;secondary outcome;Site;social culture;Social Network;Structure;therapy design;tool;treatment as usual;Trust;underserved community;Underserved Population;United States National Institutes of Health;Update;Visual;Work

PROJECT_TITLE: Engaging underserved communities in end-of-life conversations: a cluster, randomized controlled trial

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Current modalities can measure one to several unique attributes of a cell, such as spatial location, transcriptome, epigenome, morphology, and physiology, yet fail to capture how these unique profiles interact to cumulatively describe a single cell. The proposed research will create a suite of tools tailored to deriving connected cellular profiles, successfully characterizing spatial transcriptomic cells with greater cell type specificity, and integrating molecular profiles with morphological and physiological data. In completing this proposal, I will provide intuition for how spatial location effects cellular identity and begin to untangle how the underlying transcriptomic influences physiological response to stimulation, helping to establish what constitutes a normal cellular response, and what might be considered aberrant, and potentially associated with disease.

PI_NAMEs: KRIEBEL, APRIL ROSE (contact)

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TITLE: Leveraging Spatial Location for Single-Cell Molecular and Morphological Characterization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


FUNDING_MECHANISM: OTHERS

ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

PHR: Long-term neurological consequences of traumatic brain injury (TBI) may be the most critical issue facing Veterans over the next 50 years, given that TBI has become a signature injury of modern warfare. Large cohort studies in both civilian and Veteran populations have clearly demonstrated an association between TBI and an increased incidence of dementia diagnosis with advancing age. Thus, there is a critical need to identify pathophysiological mechanism(s) underlying progressive age-related neurodegeneration which are amenable to modifiable lifestyle and/or therapeutic interventions decades before the clinical presentation of cognitive impairment or dementia. This proposal aims to investigate the impact of modifiable cardiovascular risk factors on chronic TBI-related sequelae, a goal in-line with the VA’s strategic mission to implement “Whole Health for Life,” “the radical redesign of healthcare” within the VA.

PI_NAMEs: SWANSON, RANDEL L (contact)

PROJECT_TERMS: Accounting;Age;age related neurodegeneration;Alcohol consumption;Algorithmic Analysis;Amnesia;Animals;Archives;Blood Pressure;Blood specimen;Blood Vessels;Board Certification;Body mass index;Brain;Brain Injuries;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;care systems;career;career development;Categories;Cerebrum;Cholesterol;Chronic;classification algorithm;Clinical;Clinical Data;clinically relevant;Cohort Studies;combat veteran;Coupled;Data;Dementia;design;Development;Diabetes Mellitus;Diagnosis;Diffusion Magnetic Resonance Imaging;early detection biomarkers;Elderly;endophenotype;follow-up;Goals;healing;Health behavior;Healthcare;Healthcare Systems;Hyperlipidemia;Impaired cognition;Incidence;indexing;Injury;Joints;Knowledge;Laboratories;Leadership;Life;lifestyle intervention;Literature;Longitudinal cohort study;longitudinal, prospective study;marine;Measures;Medical center;Medicine;Mentorship;microvascular pathology;mild traumatic brain injury;Military Personnel;military veteran;Mission;Modality;Modernization;multidisciplinary;Multiple Trauma;Nervous System Trauma;neuroimaging;Neurologic;Outcome;Pathology;Patients;Pennsylvania;Physical activity;Physical Medicine;Physical Rehabilitation;Physicians;Positioning Attribute;Pre-Clinical Model;Prevalence;professor;Recording of previous events;repaired;Research;Research Design;Research Methodology;Research Proposals;Resource Sharing;Retrospective cohort study;Risk;Risk Factors;secondary analysis;Secondary to;Severities;sex;skills;Sleep;sleep quality;Smoking;Subgroup;Techniques;Testing;Therapeutic Intervention;Time;Training;translational approach;translational medicine;Translational Research;translational therapeutics;Traumatic Brain Injury;Unconscious State;Universities;Veterans;Water;White Matter Hyperintensity;whole health

PROJECT_TITLE: Traumatic and Treatable Vascular Pathology in the Outcome of TBI

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Healthcare access for all Veterans was adversely impacted by COVID-19 safety-related guidelines. Disruptions in care for Veterans on antipsychotic medications are particularly concerning given the patient and system level costs associated with the suboptimal treatment and monitoring of this Veteran population. The proposed project has significant and immediate relevance to Veterans and the VHA in that it seeks to better understand how COVID-19 related care disruptions impacted healthcare delivery and outcomes for Veterans on antipsychotic medications. Aside from addressing a critical knowledge gap, the proposed study seeks to identify potential strategies to further mitigate the impact of COVID-19 on the healthcare of Veterans with severe forms of mental illness as well as prepare for future public health and/or other national emergencies.

PI_NAMEs: GRUBAUGH, ANOUK L (contact)

PROJECT_TERMS: Address;Adherence;Administrator;Admission activity;Age;Age of Onset;Agranulocytosis;Antipsychotic Agents;Area;Attitude;Behavior;Bipolar Disorder;Blood Glucose;Blood Pressure;care outcomes;Caring;Chronic;Chronic Disease;Clinical;Clozapine;Code;cohort;Continuity of Patient Care;cost;COVID-19;COVID-19 impact;Data;Data Sources;Diabetes Mellitus;Diagnostic;Disease;Drug Prescriptions;economic impact;Emergency Care;Emergency Situation;ethnic minority;Ethnic Origin;Event;experience;Fasting;Future;Gender;Generations;Guidelines;Health;health care availability;health care delivery;health care service utilization;Health Personnel;Healthcare;Healthcare Systems;Heart;Heart Diseases;heart function;hospital readmission;Individual;insight;Interruption;Interview;Knowledge;Lipids;Malignant Neoplasms;Mental disorders;Mental Health;Metabolic;Methodology;Methods;Military Personnel;military veteran;Monitor;mortality;multiple data sources;neutrophil;non-compliance;Nurse Practitioners;obesity risk;Outcome;Outpatients;patient population;Patients;Pharmaceutical Preparations;Pharmacists;pharmacy benefit;Population;post-COVID-19;prevent;Provider;psychiatric inpatient;Psychiatrist;Public Health;racial difference;racial minority;racial population;relapse prevention;Research Design;Resistance;Rural;rural area;Safety;Schizophrenia;Services;severe mental illness;side effect;Statistical Methods;Suggestion;Suicide;Suicide prevention;symptom management;System;Testing;urban dwelling;Veterans;Visit;Weight;Woman

PROJECT_TITLE: Impact of COVID-19 on Continuity of Care for Veterans on Antipsychotic Medications

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE When patients recover after lung illnesses, including pneumonia, influenza or coronavirus infection, or more severe lung injuries requiring a ventilator, the lung must heal. The mechanisms by which this healing occurs are unknown, and no medications exist to help lung healing when the process does not occur correctly. We have found a new lung stem cell that is important in lung healing after injury, and this grant is testing the idea that this stem cell state is controlled by epigenetic complexes which could be targeted by drugs to improve lung regeneration.

PI_NAMEs: ZACHARIAS, WILLIAM JOHN (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Adult;adult stem cell;Affect;Alveolar;alveolar epithelium;Animals;ATAC-seq;Attention;Automobile Driving;Binding;Biology;Cell Differentiation process;Cells;Chemicals;ChIP-seq;Chromatin;Chromatin Remodeling Factor;Chronic;Cleavage Under Targets and Release Using Nuclease;Clinical;Co-Immunoprecipitations;combinatorial;Complex;Computer Analysis;constitutive expression;Coronavirus Infections;coronavirus pandemic;Cre driver;Data;Death Rate;Deposition;disability;Disease;Drug Targeting;Ensure;Epigenetic Process;epigenomics;Epithelial Cells;epithelial stem cell;epithelium regeneration;exhaustion;fibrotic lung;Future;Gases;gene repression;Genetic;Genetic Transcription;Genome;genomic locus;Genomics;Grant;healing;Homeostasis;Hospitalization;Human;Image;improved;In Vitro;in vivo;Infection;Influenza;influenza infection;Injury;insight;Laboratories;life span;Literature;Lung;Lung Diseases;lung injury;lung regeneration;Maintenance;Mechanical ventilation;Mediating;Modeling;Molecular Conformation;Mus;Natural regeneration;novel;old mice;Organ;Organoids;patient population;patient subsets;Patients;Pharmaceutical Preparations;Phenotype;Play;Pneumonia;Population;premature;prevent;Process;progenitor;Proliferating;Proteomics;Publishing;pulmonary function;pulmonary symptom;Recovery;regeneration potential;regenerative;regenerative biology;regenerative therapy;Regulation;repaired;Respiratory physiology;Respiratory System;Review Literature;Risk;RNA;Role;SARS-CoV-2 infection;self-renewal;Specific qualifier value;Specificity;Stable Populations;stem cell function;stem cell population;stem cell proliferation;stem cell self renewal;stem cells;Stress;Structure;Survivors;System;Testing;Therapeutic;therapeutic development;Time;tissue oxygenation;Tissues;Ventilator;Viral;Work

PROJECT_TITLE: Defining PRC2 complex epigenomic control in alveolar progenitor cells

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Spatial navigation, a fundamental human behavior which facilitates a safe and independent life, is among the first behaviors to decline in healthy aging and Alzheimer’s disease and related dementias, greatly contributing to poor health outcomes and a loss of independence in these populations. Supporting spatial navigation requires an understanding of how the brain constructs spatial representations from communication tools that convey spatial directions in abstracted forms (i.e., signs, maps, verbal directions, and global positioning systems). This proposal examines behavioral and neural properties of spatial direction comprehension, and how those properties are altered in older adults and individuals with amnestic mild cognitive impairment, providing a novel characterization of spatial function in the human brain.

PI_NAMEs: WEISBERG, STEVEN M (contact)

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: 3-Dimensional;Affect;Age;age related;age related neurodegeneration;Aging;aging brain;aging process;aging related;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;amnestic mild cognitive impairment;Architecture;Area;Award;Basic Science;Behavior;Behavior assessment;behavior test;Behavioral;Brain;Brain region;cerebral atrophy;clinical application;cognitive neuroscience;Communication Tools;Comprehension;Data;Dedications;Dementia;Deterioration;Disorientation;Environment;experience;Florida;Foundations;Functional Magnetic Resonance Imaging;Future;Global Positioning System;Goals;Health;healthy aging;Hippocampus;Human;Imaging Techniques;Impairment;Individual;Institution;intraparietal sulcus;Learning;Left;Life;Maps;medial temporal lobe;Methodology;mild cognitive impairment;Modeling;Nerve Degeneration;neural;neural circuit;neural network;Neurodegenerative Disorders;Neurology;neuromechanism;Neurosciences;normal aging;novel;older adult;Older Population;pathological aging;Patients;Pattern;poor health outcome;Population;Process;Property;Quality of life;Research;Research Project Grants;Research Proposals;Research Training;response;Role;skills;Testing;therapy design;tool;Universities;verbal;virtual environment;Visual;way finding;young adult

PROJECT_TITLE: Behavioral and neural properties of spatial direction comprehension in aging and amestic mild cognitive impairment

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Learning powerfully influences nearly all brain functions, from early sensory processing and control of movement, to cognition. Deficits in learning and memory present a serious challenge to individuals and society. This project will generate insights about the neural processes that transfer memories from short- to long-term storage.

PI_NAMEs: GOLDMAN, MARK S;RAYMOND, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Amygdaloid structure;Area;Automobile Driving;Behavior;Behavioral;Brain;Brain region;candidate identification;Cell Nucleus;Cerebellum;Cognition;Computer Models;conditioned fear;Data;density;Dissection;Episodic memory;experience;experimental study;Eye Movements;Foundations;Goals;Hippocampus;improved;in vivo;Individual;insight;Learning;long term memory;Measures;medial vestibular nucleus;Mediating;Memory;memory acquisition;memory consolidation;Modeling;motor learning;Motor Skills;Movement;Nature;neural;neural circuit;neural patterning;Neurons;neurotransmission;oculomotor;optogenetics;Output;predictive modeling;Process;Research;Sensory;Shapes;Short-Term Memory;Site;Societies;Synapses;System;Testing;Time;Training;transmission process;vestibular system;Vision;visual information;Work

PROJECT_TITLE: Activity-Dependent Mechanisms of Memory Consolidation

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


ORG_DEPT: PEDIATRICS

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Chronic vascular inflammation is a major cause of morbidity and mortality worldwide. This proposal seeks to improve the understanding of molecular mechanisms by which vascular inflammation develops by examining the role of endothelial cell-specific Wnt signaling suppression in endothelial inflammation and metabolism. The proposed work has the potential to influence the development of new therapeutic options for vascular inflammation.

PI_NAMEs: GOODWIN, JULIE  (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: 3-Dimensional;Affect;antagonist;Aorta;Architecture;Area;Arteries;atherogenesis;Atherosclerosis;Attenuated;Bioenergetics;Biological Assay;Blood Vessels;Cardiovascular Diseases;Cell Separation;Cells;Cellular Metabolic Process;ChIP-seq;Chromatin;chromatin immunoprecipitation;Chromatin Loop;chromosome conformation capture;Chronic;Data;Data Set;Defect;defined contribution;Development;Diabetes Mellitus;Endothelial Cells;Endothelium;Environment;experimental study;fatty acid oxidation;Fibrosis;Gene Expression;Gene Modified;Genes;Genome;Genomics;Glucocorticoid Receptor;Glucocorticoids;Goals;Heterogeneity;Hi-C;improved;In Vitro;Infiltration;Inflammation;Inflammatory;Inflammatory Response;insight;interest;LDL-Receptor Related Protein 1;Lesion;lipid metabolism;lipoprotein receptor related protein 5;Macrophage;Mediating;Mesenchymal;Metabolic;metabolic phenotype;Metabolism;Mitochondria;Modeling;Molecular;Molecular Conformation;Morbidity - disease rate;mortality;mouse model;Mus;mutant mouse model;next generation sequencing;Nitric Oxide;novel;novel therapeutic intervention;novel therapeutics;Organ;Pathogenesis;Pathologic;Pathway interactions;Phenotype;Play;preference;Production;Proteins;receptor;receptor function;Regulation;Research;Response Elements;Role;Sepsis;single-cell RNA sequencing;Systemic blood pressure;Technology;Testing;Therapeutic;Transcriptional Regulation;transcriptome;transcriptomics;Vascular Diseases;vascular inflammation;Vasodilation;WNT Signaling Pathway;Work

PROJECT_TITLE: Endothelial cell- specific Wnt suppression ameliorates vascular inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(02)M]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Public Health Relevance  Health disparities adversely affecting sexual and gender minority (SGM) adolescents and youth of color are well-documented. Stigmatizing experiences, institutionalized oppression, and lack of access to resources and services can engender emotional distress and unhealthy coping behaviors, and disparities are expected to be more pronounced for those with multiple marginalized social positions. This mixed methods study using an intersectional approach is directly responsive to the National Academy of Medicine report and the NIH’s call for research to advance the health of SGM populations; interventions built on the insights gleaned from this work will extend protective benefits across the SGM youth population and reduce persistent health disparities.

PI_NAMEs: EISENBERG, MARLA E. (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: 19 year old;Academy;Address;Adolescent;adolescent health;Adult;Affect;African American;Asian;black men;Black race;bullying;California;Characteristics;Child;children of color;cisgender;Communities;Coping Behavior;Data Set;design;Development;Disadvantaged;Disparity;emotional distress;Ethnic Origin;Ethnic Population;experience;Face;Family;Feeling;Gays;Gender;gender minority community;gender minority group;gender minority youth;Glean;Health;Health behavior;Health behavior and outcomes;health disparity;high risk;high risk sexual behavior;Immigrant;Immigrant community;Immigration;Individual;Inequality;insight;Institutionalization;intersectionality;Intervention;Interview;Language;Latino;Lesbian Gay Bisexual Transgender Queer;Literature;Location;male;marginalization;Measures;Mediating;Medicine;Methods;Minnesota;nonbinary;Outcome;peer;Personal Satisfaction;Persons;Population;Positioning Attribute;Process;Production;protective factors;public health relevance;Race;racial population;racism;Recommendation;Reporting;Research;resilience;Resources;Risk;Risk Behaviors;Risk Factors;Safety;Sampling;Schools;Services;Sex Orientation;Sexual and Gender Minorities;Sexual Health;sexual minority;sexual minority group;sexual minority health;sexual minority youth;social;Social Identification;Social status;social stigma;Stigmatization;Structure;Students;substance use;Surveys;Teenagers;Testing;theories;United States National Institutes of Health;Victimization;Work;Youth

PROJECT_TITLE: Adolescent health at the intersections of sexual, gender, racial/ethnic, immigrant identities and native language

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Prevention;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The vast majority of PCa patients present with clinically localized disease, for which radical prostatectomy (RP) represents a standard treatment option. Although RP is performed with curative intent, a significant proportion of surgically treated patients face the risk of PCa recurrence and require further treatment. Therefore, the long- term goal of this project is to develop and validate prognostic and predictive biomarkers through the analysis of tumor samples from two completed landmark phase III trials to personalize PCa patient care following surgery.

PI_NAMEs: LUO, JINGQIN ;MAHER, CHRISTOPHER A (contact);SIMKO, JEFF P

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Address;androgen deprivation therapy;Androgens;arm;biobank;Biological Assay;cancer recurrence;Clinical;clinical translation;cohort;Data;Diagnosis;Disease;disorder control;Event;Exposure to;Face;follow-up;Freedom;Gene Expression Profile;Genes;Genomics;Goals;Guidelines;high risk;High-Throughput DNA Sequencing;improved;Local Therapy;Localized Disease;Malignant neoplasm of prostate;Malignant Neoplasms;men;molecular marker;National Comprehensive Cancer Network;novel;Operative Surgical Procedures;Pathologic;Patient Care;patient subsets;Patient-Focused Outcomes;Patients;Pelvic lymph node group;Performance;personalized medicine;Phase III Clinical Trials;phase III trial;Positioning Attribute;Postoperative Period;predicting response;predictive marker;predictive modeling;predictive signature;prognostic;Prognostic Marker;prospective;prostate cancer risk;Prostatectomy;PSA level;Publishing;Radiation;Radiation therapy;Radiation Therapy Oncology Group;Radical Prostatectomy;Randomized;randomized trial;Recurrence;Research;Resources;response;Retrospective cohort;Risk;Sampling;serum PSA;side effect;standard care;standard of care;Technology;Therapeutic;Tissue Therapy;Tissues;transcriptome;transcriptome sequencing;transcriptomics;treatment strategy;tumor;United States;Vertebral column

PROJECT_TITLE: Molecular Biomarkers of Long-Term Response to Androgen Deprivation Therapy and Radiation in Prostate Cancer

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: While the MISSION Act of 2018 increased access to community providers through its Veterans Community Care Program, the quality of care provided in the community is largely unknown. We will improve existing risk adjustment methods used by VA so that rigorous and fair VA/Community Care (CC) quality comparisons can be conducted. We will make national and local quality comparisons of care for Veterans with serious mental illness (SMI) and, separately, total hip and total knee arthroplasty (THA/TKA)—both of which are in high-cost and high-volume categories of outsourced CC services. Through collaboration with our operational partners (the Office of Community Care [OCC], Analytics and Performance Integration [API], the Office of Health Equity [OHE], the Access Office, and the Serious Mental Illness Research and Evaluation Center [SMITREC]), we will provide VA leaders and policymakers with the tools to enable more informed purchasing decisions and Veterans with timely and needed guidance on which setting of care (VA/CC) is most appropriate for their care.

PI_NAMEs: ROSEN, AMY K (contact);VANNEMAN, MEGAN ENFIELD

PROJECT_TERMS: Address;Affect;Area;burden of illness;Calibration;care providers;care systems;Caring;Categories;Code;Collaborations;Communities;Community Healthcare;Community Pharmacy;community-level factor;comorbidity;cost;Data;Data Set;Data Sources;Databases;Decision Making;design;Discrimination;Disparity;Emergency department visit;Ensure;Equity;Evaluation;Future;Goals;Health;health care availability;health disparity;health equity;Health Services Accessibility;Healthcare;high risk;Hip region structure;hospital readmission;housing instability;Improve Access;improved;Individual;innovation;knee replacement arthroplasty;Measures;Medicare;Methodology;Methods;Modeling;Monitor;mortality;Odds Ratio;Outcome;outcome prediction;Outsourcing;Patients;Performance;Pharmacy facility;Policies;Policy Maker;Population;Private Sector;programs;Provider;Quality of Care;Research;Resources;Risk;Risk Adjustment;Services;severe mental illness;shared decision making;social;social health determinants;Subgroup;System;Testing;tool;tool development;Veterans;web site

PROJECT_TITLE: Comparing Quality of Care between VA-Delivered and VA-Purchased Care: The Need for Better Risk Adjustment

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative The interplay between a patient’s immune response and the genetic background of their infecting strain can lead to severe Clostridioides difficile infection. Identifying features of C. difficile genetic background that directly influence patient immune response to infection, and those factors that act independently of patient immune response to cause severe disease, could provide insights into novel mechanisms leading to severe infections. Using bacterial genomics in combination with patient health histories and clinical factors, this proposal aims to identify markers of C. difficile infection severity and novel pathways of bacterial pathogenesis and then validate predictive performance using in vitro and in vivo methods.

PI_NAMEs: MAGGIONCALDA, EMILY  (contact)

PROGRAM_OFFICER_NAME: GLOCK, JONATHAN A

PROJECT_TERMS: Adult;adverse outcome;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Bacteria;bacterial genetics;Bacterial Genome;Base Sequence;Big Data;Bioinformatics;Biological Markers;Biological Models;biomarker identification;Centers for Disease Control and Prevention (U.S.);Clinical;Clostridium;Clostridium difficile;Complement;cost;cytokine;Data;Data Analyses;data repository;Data Set;Disease;Electronic Health Record;Epidemiology;Exhibits;experience;Genes;Genetic;genetic makeup;genetic strain;genetic variant;Genetic Variation;Genome;genome wide association study;Genomics;Germination;gut colonization;gut inflammation;gut microbiome;gut microbiota;Health;healthcare burden;Healthcare Systems;healthcare-associated infections;Immune;Immune response;improved;In Vitro;in vivo;Incidence;Individual;Infection;insight;Integration Host Factors;Investigation;Knowledge;Machine Learning;Measurement;Measures;Mediating;Medicine;Metadata;Methods;Michigan;microbiome;Morbidity - disease rate;mouse model;new therapeutic target;novel;novel therapeutics;Outcome;pathogen;Pathogenesis;Pathway interactions;Patient Care;Patient risk;Patient-Focused Outcomes;Patients;Performance;Phylogeny;predictive modeling;Predictive Value;Process;Recording of previous events;Reporting;repository;Reproduction spores;Resolution;response;Risk Factors;Role;Sampling;Serum;Severities;Structure;Symptoms;Testing;Toxin;Training;treatment strategy;Validation;Variant;Virulence Factors;whole genome;Work

PROJECT_TITLE: Elucidating genetic mechanisms of Clostridioides difficile pathogenesis and patient immune manipulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07B-U(20)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Acute kidney injury (AKI) is a common complication of cisplatin chemotherapy, and effective therapeutic and preventative strategies for cisplatin-associated AKI (CP-AKI) are lacking. In this proposal, we will study the association between intravenous magnesium (IV Mg), mannitol, metformin, and statins and CP-AKI using a target trial framework; we will evaluate in a double-blind, randomized, placebo-controlled trial whether the administration of IV Mg reduces the risk of CP-AKI in patients receiving hyperthermic intraoperative chemotherapy with cisplatin; and we will examine in a prospective cohort study whether urinary quinolinate normalized to tryptophan, a novel marker and potential therapeutic target for AKI in other contexts, is elevated in patients with CP-AKI.

PI_NAMEs: GUPTA, SHRUTI  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Adult;Advisory Committees;Animal Model;Anticoagulation;Apoptosis;Area;Area Under Curve;Attenuated;attenuation;biobank;Biological Markers;Blood;Cancer Center;cancer therapy;Cardiac Surgery procedures;chemotherapy;Chemotherapy-Oncologic Procedure;Cisplatin;Clinical;Clinical Trials;comorbidity;Complication;Conduct Clinical Trials;Continuous Infusion;COVID-19 patient;Creatinine;Critical Illness;Dana-Farber Cancer Institute;Data;Data Set;Databases;demographics;design;Dose;Double-Blind Method;efficacy testing;Environment;Epidemiologic Methods;Epidemiology;Event;Extracorporeal Membrane Oxygenation;Future;Goals;high risk;Homeostasis;Hour;Hyperthermia;Hypomagnesemia;Impairment;Incidence;Injury;injury prevention;Injury to Kidney;innovation;Intervention;Intravenous;intravenous administration;Laboratories;LCN2 gene;Magnesium;Malignant neoplasm of testis;Malignant Neoplasms;Mannitol;Mentors;Mentorship;Mesothelioma;Metabolic stress;Metformin;Morbidity - disease rate;mortality;Nephrology;new therapeutic target;Niacinamide;Nicotinamide adenine dinucleotide;Non-Small-Cell Lung Carcinoma;novel;novel marker;Observational Study;Oncologist;Oral;Outcome;Oxidative Stress;Pathway interactions;patient oriented;patient oriented research;Patient Recruitments;Patients;Pharmaceutical Preparations;Placebos;Plant Leaves;Plasma;Platinum;Postoperative Period;Pre-Clinical Model;prevent;Prevention;Prevention strategy;primary outcome;Prone Position;prophylactic;prospective;Prospective, cohort study;protective effect;Publishing;quinolinate;Randomized;randomized placebo controlled trial;randomized, clinical trials;rat KIM-1 protein;recruit;Renal Replacement Therapy;Research Personnel;Risk Reduction;Saline;Sampling;secondary outcome;Serum;Serum Magnesium Level;skill acquisition;skills;Specific qualifier value;statistics;Testing;therapeutic target;therapeutically effective;tocilizumab;Training;translational approach;Translational Research;Tryptophan;Tubular formation;urinary;Urine

PROJECT_TITLE: Novel Pathways and Therapeutic Targets for Cisplatin-Associated Acute Kidney Injury

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Cancer results from the accumulation of mutations in critical genes controlling cell division. The proposed research will provide insight into the mechanisms driving the accumulation of mutations. This information is important for designing strategies to prevent or delay cancer development and improve therapy outcomes.

PI_NAMEs: SHCHERBAKOVA, POLINA V (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Affect;Alleles;Amino Acids;Animal Model;Automobile Driving;Biochemical;Biological;Biological Assay;Biological Models;Bypass;cancer risk;Cell division;Cell Proliferation;Cells;Classification;Colon;Colorectal Cancer;correctional system;cost;Data;Defect;design;Development;DNA Polymerase II;DNA Structure;DNA-Directed DNA Polymerase;Endometrial Carcinoma;Environment;Epithelial Cells;Etiology;Exonuclease;Future;gain of function;Genes;Genomic Instability;Goals;Human;improved;innovation;insight;Laboratories;Link;loss of function;Malignant Neoplasms;Modeling;Mus;Mutagenesis;mutant;Mutation;mutation carrier;Nature;novel;Nucleotides;Pathogenicity;personalized medicine;Phenotype;Phosphodiesterase I;Polymerase;polymerization;Polymers;Predisposition;prevent;Prognosis;Property;Proteins;Reaction;reconstitution;Recurrence;Research;Role;Specificity;Testing;therapy outcome;tool;treatment response;tumor;tumorigenesis;Variant;variant detection;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Mechanisms of Genome Instability in Tumors with DNA Polymerase Epsilon Mutations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-K(02)M]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE The proposed study seeks to advance management of women with type 2 diabetes mellitus receiving antenatal corticosteroids by testing the efficacy of three treatment strategies at achieving maternal glycemic control and subsequently evaluating the association between maternal glycemic control and neonatal outcomes. This will enhance the candidate’s career development to independent research in type 2 diabetes mellitus and pregnancy.

PI_NAMEs: BATTARBEE, ASHLEY NICOLE (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Adrenal Cortex Hormones;Alabama;Algorithms;antenatal;Award;Behavioral Sciences;Biometry;career development;Caring;Client satisfaction;Clinical;Clinical Management;clinical practice;Clinical Trials;comparison control;Continuous Glucose Monitor;cost;Data;data acquisition;Development Plans;Diabetes Mellitus;Discipline of obstetrics;efficacy testing;Endocrinology;Enrollment;Ensure;evidence base;Exclusion;experience;fetal;Funding;Glucose;glucose monitor;glycemic control;Goals;Grant;Health Resources;high risk population;High Risk Woman;Home;Hyperglycemia;Hyperinsulinism;implementation science;improved;Infusion procedures;Insulin;Interdisciplinary Study;Intervention;Knowledge;Lung;Maternal and Child Health;maternal hyperglycemia;maternal risk;Measures;Mentors;Metabolic dysfunction;Multi-Institutional Clinical Trial;Multicenter Trials;multidisciplinary;Neonatal;neonatal morbidity;neonatal outcome;Neonatal respiratory morbidity;neonate;Neonatology;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Population;Positioning Attribute;Pregnancy;Pregnancy Complications;Pregnant Women;Premature Birth;prospective;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Regimen;Research;Research Design;Research Personnel;respiratory;Retrospective Studies;Sample Size;Scientist;Secure;side effect;skill acquisition;skills;Slide;Specific qualifier value;Standardization;Structure;Testing;theories;Time;Titrations;Training;Training Programs;treatment strategy;United States;Universities;Variant;Woman;women's outcomes;Writing

PROJECT_TITLE: Close the GAP: Glycemic control after Antenatal corticosteroids in women with Pregestational diabetes

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Nanotechnology;Prevention;Women's Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE This preclinical study will determine the effectiveness of a refined ablative solution at preventing breast tumor formation in cancer-prone rodent models and the scalability of this intraductal procedure to humans by using rabbits as an intermediate and relevant larger animal model. This procedure could lead to a breakthrough in primary prevention of breast cancer by providing a minimally invasive local intervention.

PI_NAMEs: SEMPERE, LORENZO  (contact)

PROGRAM_OFFICER_NAME: SAUTER, EDWARD RICHARD

PROJECT_TERMS: Ablation;ablative procedure;Adverse effects;Affect;Alcohol consumption;Animal Model;Animals;Anxiety;brca gene;Breast;Breast Cancer Model;Breast Cancer Prevention;Breast Epithelial Cells;Cancer Etiology;Cannulations;Cattle;cell regeneration;Cells;Cellulose;Chemicals;Clinical;Clinical Research;Clinical Trials;Contrast Media;Data;Diagnostic;Duct (organ) structure;effectiveness evaluation;Emotional;Epithelial Cells;Epithelium;Esthetics;Ethanol;evidence base;experimental group;Fibrosis;first-in-human;Fluoroscopy;follow-up;Gene Mutation;Genetic;high risk;High Risk Woman;Human;Image;Image Analysis;image guided;Imaging Techniques;in vivo;in vivo imaging;in vivo monitoring;Incidence;Infusion procedures;Injections;Intervention;Knowledge;Lead;Li-Fraumeni Syndrome;Localized Malignant Neoplasm;Logistics;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;Mammary Neoplasms;Manuals;Mastectomy;Methods;minimally invasive;Modeling;Molecular;mouse model;nanoparticle;Operative Surgical Procedures;Oryctolagus cuniculus;Patient observation;pre-clinical research;preclinical study;premalignant;prevent;Prevention strategy;preventive intervention;Primary Prevention;Procedures;Process;prophylactic mastectomy;Protocols documentation;psychologic;Publishing;Pump;Quality of life;Rattus;Research;research study;Resolution;Risk;Rodent Model;Safety;Sheep;side effect;social;System;tantalum oxide;Testing;Therapeutic;Tissues;Toxic effect;Translational Research;Treatment Efficacy;Trees;tumor;Visualization;Woman;Women's mortality;X-Ray Medical Imaging

PROJECT_TITLE: Image-Guided Intraductal Ablative Procedure for Primary Prevention of Breast Cancer

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Asthma;Clinical Research;Emergency Care;Health Services;Lung;Pediatric;Precision Medicine

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE  This proposal will leverage an improved understanding of an individual's biologic and physiologic response to emergent asthma therapies to inform biomarker-directed, individualized asthma therapy; a paradigm shift in the Emergency Department (ED) management of pediatric acute asthma exacerbations. A clinical prediction model incorporating objective markers of ED treatment response will be developed to guide clinical decisions, facilitate timely and appropriate therapeutic interventions and disposition decisions, and improve clinical outcomes for children acute asthma exacerbations.

PI_NAMEs: NAVANANDAN, NIDHYA  (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Acceleration;Accident and Emergency department;Accounting;Acute;Acute Respiratory Distress Syndrome;Address;Adrenal Cortex Hormones;Airway Resistance;Asthma;asthma exacerbation;Automobile Driving;Biological;Biological Markers;Biological Response Modifier Therapy;Bronchodilator Agents;career;career development;Caring;Child;Childhood;Childhood Asthma;Chronic;Clinical;clinical practice;clinical predictive model;clinical predictors;Clinical Research;Development Plans;diagnostic biomarker;Effectiveness;Emergency Care;Emergency department visit;Emergency Medicine;Enrollment;Ensure;Epithelial Cells;experience;feasibility trial;Funding;Future;Genes;Goals;Home;hospital readmission;Hospitalization;improved;improved outcome;Individual;individualized medicine;Infrastructure;Inhalation;innovation;Institution;Interferons;K-Series Research Career Programs;Knowledge;Laboratories;Lead;Leadership;Length of Stay;Measures;Mentors;Mentorship;Methods;Modeling;Molecular Genetics;Morbidity - disease rate;mortality;multidisciplinary;Nasal Epithelium;Nose;novel;novel diagnostics;novel marker;Oscillometry;Outcome;Outpatients;pediatric emergency;personalized approach;Physicians;Physiological;Positioning Attribute;Prediction of Response to Therapy;Predictive Analytics;predictive modeling;prospective;Prospective Studies;pulmonary function;Research;Research Methodology;Resources;response;Scientist;skills;Spirometry;success;targeted treatment;Testing;Therapeutic Intervention;therapy development;Time;tool;Training;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;treatment response;treatment strategy;unnecessary treatment;Validation;Variant;Work

PROJECT_TITLE: Novel Markers of Treatment Responsiveness for Pediatric Acute Asthma Exacerbations

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Genetics;Kidney Disease;Prevention

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: 8. Project Narrative Genetic variants in a single gene, APOL1, account for the very high rate of kidney disease in African Americans, and also confer resistance to Sleeping Sickness in Africa. We want to understand precisely how these genetic variants lead to this major disparity in kidney disease at a biological level. Understanding how these differences in the APOL1 gene cause kidney disease in African Americans will have direct implications for improving all aspects of care for the growing number people with this serious public health problem and ultimately removing a major racial health disparity.

PI_NAMEs: FRIEDMAN, DAVID J (contact);POLLAK, MARTIN R.

PROGRAM_OFFICER_NAME: MARTIN, IMAN

PROJECT_TERMS: Affinity;Africa;African American population;African ancestry;African Trypanosomiasis;Alleles;American;Bacterial Artificial Chromosomes;Behavior;Binding;Biochemical;Biological;Biological Models;Biology;Caring;Cell Death;Cell Physiology;Cells;Code;cytotoxic;cytotoxicity;Data;Disease;disorder risk;Disparity;Dose;Drosophila genus;Elements;endophenotype;Endoplasmic Reticulum;Engineering;European;experimental study;Foot Process;gain of function;gain of function mutation;Gene Dosage;Genes;Genetic;genetic variant;Genome;Genotype;Goals;Heterozygote;high risk;Human;human tissue;Image;improved;In Vitro;in vivo;Individual;Inflammatory;Inherited;insight;Interferons;Kidney;kidney cell;Kidney Diseases;Kidney Failure;Label;Lead;Link;Lipids;Literature;loss of function;loss of function mutation;Mediating;Mitochondria;mitochondrial dysfunction;Mitochondrial Matrix;Molecular;mouse model;Movement;Mus;Names;Organoids;overexpression;Pathway interactions;Persons;Phenotype;prevent;Primates;Property;Proteins;Proteinuria;Public Health;Publishing;racial health disparity;recessive genetic trait;recruit;Reproducibility;Resistance;Risk;Risk Behaviors;risk variant;Role;Seminal;Stains;Stimulus;Support System;System;Testing;Toxic effect;trafficking;Transcript;Transgenic Mice;Variant;Work;Yeasts

PROJECT_TITLE: APOL1 Nephropathy: Linking Genetics and Mechanisms

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

PHR: COVID-19 pandemic dramatically disrupted primary care causing profound impacts on morbidity and mortality related to chronic and preventive disease care. Department of Veterans Affairs (VA) Office of Primary Care (OPC) provides primary care to over 6 million Veterans and is responsible for mitigating the effects to chronic and preventive care caused by these disruptions. On March 1st 2020, OPC launched a multi-component care coordination intervention called Preventative Health Inventory (PHI). Early data suggests increasing adoption across the VA. However, significant knowledge gaps remain around PHI implementation and outcomes. Our proposal is a rapid-cycle evaluation aimed to fill these knowledge gaps and support OPC in mitigating the impact of COVID-19 on chronic and preventive care.

PI_NAMEs: REDDY, ASHOK  (contact)

PROJECT_TERMS: acute COVID-19;Address;Adoption;Blood Pressure;care coordination;care delivery;Care given by nurses;Caring;Case Manager;Chronic;Chronic Care;Chronic Disease;Clinic;cohort;Collaborations;colon cancer screening;colorectal cancer screening;comparison group;COVID-19;COVID-19 impact;COVID-19 pandemic;dashboard;Data;Development;Diabetes Mellitus;Diffusion;Disease;Disease Management;Early Diagnosis;Effectiveness;Electronic Health Record;electronic structure;Electronics;Emergency department visit;Equipment and supply inventories;Evaluation;experience;Frontline worker;Glycosylated hemoglobin A;Health;Health Services;Health system;Hospitalization;Hypertension;implementation evaluation;improved;improved outcome;Infrastructure;innovation;insight;Intervention;Interview;Knowledge;Licensing;Managed Care;Measurement;Measures;member;Methodology;Modeling;Monitor;Morbidity - disease rate;mortality;multilevel analysis;Outcome;pandemic disease;pandemic impact;pandemic response;patient centered medical home;Patients;Policy Maker;Prevention;Preventive;Preventive care;Preventive healthcare;Primary Care;primary care clinic;primary care patient;primary care services;primary care team;programs;Provider;Quality of Care;Quasi-experiment;Recovery;Research Design;Research Personnel;response;screening;Screening for cancer;Series;service delivery;Services;Structure;Team Nursing;Telephone;Testing;tool;United States Department of Veterans Affairs;uptake;Variant;Veterans;Veterans Health Administration;video visit;virtual;virtual delivery;virtual healthcare;Visit;Work

PROJECT_TITLE: COVID-19 Preventive Health Inventory: Evaluating a primary care approach to catching-up on needed chronic and preventive care for Veterans


PHR: VA hospitals measure the performance of clinicians though routine review of clinical care. These Ongoing Professional Practice Evaluations (OPPE) determine if clinicians are competent to continue VA practice. The current OPPE process is inefficient and does not have clear benefits for professional development or patient care. A new VA mandate requires national standards of practice for all clinicians, and methods to enforce these standards. With a focus on outpatient cardiology care, we propose to develop and test a novel two-tiered OPPE system. First, clinicians will be assessed with electronic quality measures. Our research will establish the reliability of these measures and determine the best ways to measure clinicians. Clinicians with substandard performance on quality measures will then be assessed by peer review. Our research will determine the best methods for peer review. Finally, we will survey and interview clinicians to determine how current and proposed OPPE methods impact their practice and their professional development.

PI_NAMEs: DOLL, JACOB A (contact)

PROJECT_TERMS: Adherence;Agreement;American Medical Association;Benchmarking;Blinded;Cardiac;Cardiology;care delivery;Caring;case-based;Certification;Clinical;Clinical assessments;clinical care;clinical practice;cohort;Collaborations;Data;Decentralization;Development;Electronic Health Record;Electronics;Ensure;Evaluation;evidence base;Face;Feedback;Goals;Healthcare;Hospitals;implementation barriers;improved;innovation;instrument;Intervention;Interview;Investigation;Joints;Knowledge;Licensure;Link;Measurement;Measures;Medical;Medical center;medical specialties;Methodology;Methods;Monitor;novel;Online Systems;Outpatients;Patient Care;Patient-Focused Outcomes;Peer Review;Perception;Performance;Policies;Positioning Attribute;prevent;Procedures;Process;Professional Practice;programs;Provider;Quality of Care;Reporting;Research;Safety;Sample Size;Surveys;System;Testing;theories;tool;trustworthiness;Validity and Reliability;Veterans;web platform;Work

PROJECT_TITLE: Improving Performance Evaluation of Clinicians to Support National Standards of Practice

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

ORG_STATE: TX

PHR: Timely screening for serious conditions lies at the heart of effective preventive care and can help prevent poor health outcomes and mortality among Veterans. However, COVID-19 dramatically impacted preventive screening efforts in the US and elsewhere, by shuttering clinics that conducted in-person screenings for “high- touch" conditions such as cancer, and by making coordination with specialists, such as mental health providers, more difficult. Our study seeks to better understand and optimize screening workflow within VA primary care teams, and between primary and specialty care teams within during such crises, in order to maintain continuous, high-quality screening service to Veterans regardless of public health conditions. Our findings will contribute to the VA’s ability to fulfill its “Fourth Mission” of providing resources and assistance to all Americans during national emergencies.

PI_NAMEs: HYSONG, SYLVIA J. (contact)

PROJECT_TERMS: Accountability;Address;Adopted;American;Behavior;Breast Cancer Detection;Caring;Categories;Cause of Death;Cervical Cancer Screening;Chronic Disease;Clinic;Clinical;colon cancer screening;Complex;Country;COVID-19;COVID-19 pandemic;Data;Data Analyses;design;Detection;Diagnosis;Disease;Disease Management;Drops;Early treatment;emergency preparedness;Emergency Situation;Ensure;exhaust;Exhibits;experience;Focus Groups;Future;Genetic Transcription;Goals;Health;Health Personnel;Healthcare;Heart;Human Resources;improved;Individual;Interruption;Intervention;Interview;Lead;Leadership;Malignant Neoplasms;Maps;Measures;Medical center;medical specialties;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methods;Mission;Modeling;mortality;notch protein;Oncology;Outcome;Outpatients;pandemic disease;Participant;Patients;Pattern;Performance;Persons;poor health outcome;post-pandemic;Post-Traumatic Stress Disorders;Predisposition;prevent;Prevention;Preventive care;Preventive screening;Preventive service;Primary Care;primary care team;Procedures;Process;programs;Public Health;public health emergency;Quality of Care;Recommendation;Research;Resources;Role;routine screening;rurality;screening;Screening for cancer;screening services;Services;Shapes;Site;Specialist;Strategic Planning;Structure;Symptoms;System;telehealth;Testing;Time;Touch sensation;Transcript;tv watching;Update;Variant;Veterans;Woman;Work

PROJECT_TITLE: Maintaining Preventive Care during Public Health Emergencies through Effective Coordination


PHR: Treatment effects may vary with time for several reasons, including changes in policies or attitudes over time, interaction with simultaneous delivery system change, and differences between early and late adopters. To the extent these differences are ignored, treatment effect estimates can be biased, leading promising treatments to be overlooked or allowing harmful practices to be sustained. Our results will improve investigators’ ability to generate rigorous evidence from studies of Veterans’ geriatric and palliative care in which treatment or event timing cannot be controlled.

PI_NAMEs: GARRIDO, MELISSA M (contact)

PROJECT_TERMS: Academy;Accounting;Address;Adult;analytical method;Attitude;Body Weight decreased;Calendar;care recipients;care systems;Caring;Characteristics;cohort;Communities;Data;Data Collection;Data Pooling;data warehouse;Elderly;end of life care;Entropy;Equilibrium;Evaluation;Event;experience;Geriatrics;Goals;Health and Retirement Study;health care quality;Healthcare;Healthcare Systems;Heterogeneity;improved;innovation;interest;Intervention;Lead;Length;Longitudinal Studies;Medicine;Methodology;Methods;Monte Carlo Method;Observational Study;Outcome;Palliative Care;Performance;Policies;Policy Analysis;Probability;Process;Program Evaluation;programs;Randomized, Controlled Trials;Research Personnel;Resources;Retrospective cohort;Retrospective cohort study;Sampling;Seasons;secondary analysis;Self Direction;simulation;Surveys;System;Time;treatment effect;treatment group;vector;Veterans;Weight

PROJECT_TITLE: Heterogeneity in Treatment Effect Timing in Geriatrics and Palliative Care Studies

STUDY_SECTION_NAME: HSR-3 Healthcare Informatics[HSR3]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Lung;Lung Cancer;Lymphatic Research;Patient Safety

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Our goal is to reduce diagnostic and treatment errors, improve survival, and increase the value of care for lung cancer patients by improving our ability to select patients who benefit from a lymph node biopsy prior to starting treatment. This study determines the effectiveness of guideline recommended selection criteria for a pretreatment lymph node biopsy, and it tests whether a novel approach to selecting patients for lymph node biopsy is equivalent to guideline recommended strategy in terms of survival but superior in terms of lower biopsy-related severe adverse events and health expenditures. Findings from this study will lead to: 1) developing and testing implementation strategies designed to increase guideline-concordant lymph node evaluation, 2) alternative guideline recommendations for lymph node evaluation, and/or 3) justifying trials comparing outcomes between different lymph node evaluation strategies.

PI_NAMEs: FARJAH, FARHOOD  (contact)

PROGRAM_OFFICER_NAME: MARCUS, PAMELA M

PROJECT_TERMS: Address;Adoption;Adverse event;Biopsy;Cancer Patient;Cancer Research Network;care costs;Caring;Case Mixes;Characteristics;chemotherapy;Classification;Clinical;cohort;comparative effectiveness;comparative effectiveness study;cost;Data;data sharing;Databases;design;Diagnostic;Diagnostic Errors;Disease;effectiveness evaluation;Electronic Health Record;Eligibility Determination;Evaluation;follow-up;Funding;Goals;Guidelines;Health Expenditures;Health Services Accessibility;high risk;Hospitals;Image;implementation strategy;improved;Infrastructure;Injury;Investigation;Learning;Level of Evidence;Life;Link;lung cancer screening;lymph node biopsy;lymph nodes;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Modeling;models and simulation;National Cancer Institute;neoplasm registry;Network Infrastructure;Nodal;Non-Small-Cell Lung Carcinoma;novel;novel strategies;Observational Study;Operative Surgical Procedures;Outcome;Pathologic;Patient Care;Patient Selection;Patient-Focused Outcomes;Patients;Patterns of Care;Pilot Projects;Practice Guidelines;predictive modeling;Procedures;Process;radiological imaging;Recommendation;Research Design;Risk;Risk Estimate;Selection Criteria;Selection for Treatments;Serious Adverse Event;Site;Specialist;Staging;Survival Rate;Techniques;Testing;Time;Translating;treatment optimization;trial comparing;tumor;Uncertainty;Unnecessary Surgery;Variant;Vital Status;Work

PROJECT_TITLE: Comparative-Effectiveness of Pretreatment Lung Cancer Nodal Staging

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]