NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: PEDIATRICS

PHR: Project Narrative Toddlers with recurrent wheeze, particularly from low-income urban settings, are at higher risk of developing asthma and suffering long-term consequences of their airways disease. This project investigates how different types of asthma develop over time from ages 2 to 6 years with the objective of identifying critical windows along the airway development pathways that lead to lung dysfunction and disease. These time points are potential targets for interventions that could change the course of the disease, which will advance the goal of preventing asthma and improving child health.

PI_NAMEs: LIU, ANDREW H (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Address;Affect;Age;Airway Disease;airway epithelium;airway obstruction;Asthma;asthma prevention;Automobile Driving;Biology;Characteristics;Child;Child Health;Childhood;Childhood Asthma;Clinical;Clinical Research;clinical research site;clinical translation;cohort;Collaborations;Colorado;Coupled;design;Development;Disease;early childhood;electric impedance;experience;Faculty;follower of religion Jewish;Functional disorder;Future;Genetic Transcription;Goals;Health;high risk;improved;infancy;Inflammation;inhibitor therapy;inner city;innovation;insight;Intervention;Investigation;Knowledge;Lead;Life;Longitudinal cohort study;Low income;lower income families;Lung;lung development;Maps;Measurement;Measures;medical schools;Mentors;Methods;Molecular;National Institute of Allergy and Infectious Disease;Nature;Nose;novel strategies;Outcome;Pathway interactions;Pediatric Hospitals;personalized medicine;Phenotype;Physiological;Physiology;pneumography;prevent;programs;Public Health;pulmonary function;Recording of previous events;recruit;Recurrence;Research;Research Design;Research Personnel;research study;resilience;Risk;Role;Sampling;Science;Techniques;Time;Toddler;transcriptome;transcriptome sequencing;translational scientist;Universities;urban children;urban setting;Wheezing

PROJECT_TITLE: Critical Windows in the Development of Asthma Endotypes and Phenotypes in High-Risk Toddlers


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE The liver is known for a remarkable regenerative ability through the proliferation of the main functional cell type of the liver, the hepatocyte; however, in end stage liver disease (ESLD), hepatocyte proliferation is exhausted. To overcome the scarcity of donor livers for transplantation to treat ESLD, promotion of the liver’s own biliary epithelial cell (BEC)-mediated regeneration could provide a pool of functional hepatocytes that replenish the liver, thereby recovering liver function. The proposed research is relevant to public health and the NIH mission, as it will establish new therapeutic interventions to promote generation of functional hepatocytes derived from BECs with VEGFA delivered in the liver via clinically safe non-integrative nucleoside-modified mRNAs complexed to lipid nanoparticles.

PI_NAMEs: GOUON-EVANS, VALERIE B (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Ablation;Acute;acute liver injury;Affect;Albumins;Apoptosis;Bile fluid;Biliary;Bilirubin;Cause of Death;cell dedifferentiation;Cell Lineage;cell type;Cells;Chemical Models;Chemicals;cholangiocyte;Chronic;Cirrhosis;Clinical;clinically significant;Complex;Data;disease model;Disease regression;Documentation;Dominant-Negative Mutation;end stage liver disease;Endothelial Cells;Epithelial Cell Proliferation;Epithelial Cells;exhaust;Face;Fibrosis;Fishes;Generations;genetic approach;Goals;Hepatocyte;Human;in vivo;Inflammation;injured;Injury;Investigation;KDR gene;Knock-out;Knockout Mice;lipid nanoparticle;Liver;liver cell proliferation;Liver diseases;liver function;liver injury;Liver Regeneration;liver repair;Liver Stem Cell;liver transplantation;MAP Kinase Gene;Maps;Mediating;Mediator;Messenger RNA;Metabolic;Mission;Mitogens;Modeling;Molecular Mechanisms of Action;mortality;mouse model;Mus;Natural regeneration;novel;novel therapeutic intervention;Nucleosides;Organ Donor;overexpression;p38 Mitogen Activated Protein Kinase;Pathway interactions;Persons;Phase;PI3K/AKT;prevent;Procedures;Process;Proliferating;Public Health;Rattus;Reaction;Recovery;regenerative;repaired;Reporting;Research;Rodent;Role;senescence;stem cells;Testing;Therapeutic;therapeutic target;Therapeutic Uses;Transgenic Organisms;Transplantation;United States National Institutes of Health;VEGFA gene;virtual;Zebrafish

PROJECT_TITLE: Investigation of the role of VEGFA in harnessing cholangiocyte-driven liver regeneration

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Complementary and Integrative Health;Data Science;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Microbiome;Nutrition;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PI_NAMEs: XAVIER, RAMNIK J (contact)

PROJECT_TERMS: Acceleration;Algorithms;Applications Grants;Basic Science;biobank;Bioinformatics;Biological Markers;Biological Response Modifier Therapy;Biopsy;Blood specimen;Cells;Clinical;Clinical Data;clinical database;Clinical Research;Clinical Trials;Clostridium difficile;cohort;Cohort Analysis;Collaborations;Collection;Colon;Colonoscopy;Communities;Computerized Medical Record;Consultations;Crohn's disease;Data;Data Analyses;Data Collection;Databases;Diagnosis;Diet;Disease;disease diagnosis;Disease Outcome;disease phenotype;Disease Progression;DNA Library;Early Diagnosis;Education;efficacy study;Endoscopy;Enrollment;Environment;Environmental Exposure;Evaluation;Event;Fatigue;fecal metabolome;fecal microbiome;fecal transplantation;Feces;Gastrointestinal Diseases;Gene Cluster;gene function;General Hospitals;Genetic;genomic data;genomic locus;Genomics;Genotype;genotyped patients;Health;Human;Human Genetics;Human Microbiome;improved;in silico;in vivo;Individual;Infection;Inflammatory Bowel Diseases;Infrastructure;insight;Institution;interest;Intervention;knowledgebase;Laboratory Finding;Laboratory Research;Libraries;Life;Link;Longitudinal cohort;Maps;Massachusetts;Mental Depression;metabolomics;Metadata;Metagenomics;metatranscriptomics;Methods;microbial;microbiome;Molecular;Monitor;Natural Language Processing;Newly Diagnosed;participant enrollment;Patients;Phenotype;phenotypic data;Physicians;Probiotics;prognostication;prospective;Prospective cohort;Protocols documentation;Publications;rare variant;Registries;relapse prediction;repository;Research;Research Design;Research Personnel;research study;Research Support;Resources;response;risk stratification;Role;Sampling;Scientist;Serum;service organization;Services;Site;success;Symptoms;Testing;Therapeutic;Tissue Sample;Tissues;tool;Training;Training and Education;transcriptome sequencing;Translating;translational study;Translations;treatment optimization;treatment response;Ulcerative Colitis;Urine;Variant

PROJECT_TITLE: Clinical Core


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: NARRATIVE – Cornell Center for Reproductive Genomics (Overall) Infertility afflicts 10% of couples in the United States, 50% of which are due to male factors, predominantly resulting from errors in sperm production, leading to abnormal sperm morphology, inviable sperm, or low sperm numbers. Studies in the current P50 program will critically address the genetic, transcriptomic and epigenomic mechanisms of spermatogenesis and how these crucial gene regulatory events determine sperm quality. An important aspect of the translational approach is to use the basic biology to define new benchmarks and criteria by which to judge the fertilization potential of sperm from men with a high rate of sperm morphological abnormalities.

PI_NAMEs: COHEN, PAULA ELAINE (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: 3' Untranslated Regions;Address;Affect;Alternative Splicing;Aneuploidy;Assisted Reproductive Technology;ATAC-seq;Benchmarking;Biology;Bromodomain;career;Cells;Child;Chromatin;Chromatin Remodeling Factor;Clinical;clinically significant;Collaborations;combinatorial;Communities;Complex;Couples;Defect;Deposition;Development;Ensure;Environment;Epigenetic Process;epigenomics;epitranscriptomics;Event;Faculty;Fertility;Fertilization;Foundations;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Transcription;Genome;genomic profiling;Genomics;Germ Cells;Goals;Grant;Haploidy;Head;high throughput screening;Histones;Human;improved;indexing;Infertility;innovation;insight;Institution;interest;Life Cycle Stages;male;male fertility;meetings;Meiosis;men;Mentorship;Messenger RNA;Methylation;Modification;Morphology;mouse model;mRNA Stability;mRNA Translation;Mus;New York;next generation sequencing;Nuclear;Participant;Pathogenicity;Patients;Pattern;Pennsylvania;Pilot Projects;Play;Polyadenylation;Population;Post-Transcriptional Regulation;posttranscriptional;Process;Production;Property;Protamines;Proteins;recruit;Regulation;Regulatory Pathway;Reproduction;reproductive;Reproductive Biology;Research;Resources;RNA;RNA metabolism;Role;role model;Rural;school district;Schools;Scientist;Site;Source;Specialized Center;sperm cell;Sperm Count Procedure;sperm function;sperm morphology;Sperm Motility;sperm quality;Spermatocytes;Spermatogenesis;Spermatogenic Cell;Spermiogenesis;stem cells;symposium;Technology;Testing;Testis;Time;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;translational approach;Translations;underserved community;United States;Universities;Untranslated RNA;Variant

PROJECT_TITLE: Spermatogenic gene regulation and infertility


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative A principal goal of modern human genomics is to identify the genetic variants that contribute to disease risk and to learn about the population genetic forces that govern their prevalence and distribution. However, because global patterns of human genetic variation are shaped by the geography of our evolutionary history, existing statistical methods that ignore the geography of genetic variation are inadequate. To address this shortfall, we propose to incorporate geography into new statistical methods for studying population genetic structure, admixture, and selection, which together will yield new insights into human evolutionary history and the etiology of human disease.

PI_NAMEs: BRADBURD, GIDEON  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Admixture;Computer software;Data Set;Demography;Detection;disorder risk;DNA analysis;Environment;Etiology;expectation;Gene Frequency;Genetic Population Study;Genetic Processes;genetic variant;Genetic Variation;Genome;genomic data;Genomic DNA;Genomic Segment;Genomics;Genotype;Geography;Goals;Height;Heterogeneity;Human;human disease;Human Genetics;human genomics;Individual;insight;Joints;Learning;Length;Link;Methods;Modeling;Modernization;Movement;Natural Selections;novel;open source;Pattern;Phenotype;Polygenic Traits;Population;Population Analysis;Population Density;population genetic structure;Population Genetics;Population Replacements;Prevalence;Process;Recording of previous events;Research;Research Personnel;Sampling;Shapes;simulation;Slide;spatiotemporal;Statistical Methods;Testing;Time;trait;Work

PROJECT_TITLE: Incorporating geography into statistical methods for analysis of population genomic DNA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


PROJECT_TITLE: Administrative Core


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Human Genome;Infectious Diseases;Pediatric;Primary Immunodeficiencies;Rare Diseases;Sepsis

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE While risk for severe infection is known to have a heritable component with offspring of parents who died from infection at a young age having a 6-fold increase in their risk of death from infection, the contributing genetic factors remain unknown. Using whole exome sequencing, this project aims to identify genetic sites of immune variation that associate with the development of sepsis-associated thrombotic microangiopathy and hyperinflammation, phenotypes at high-risk of poor sepsis outcome. This effort will identify specific genotypes that convey risk for poor outcome and may identify outcome-associated mechanisms as potential future therapeutic targets in severe pediatric sepsis.

PI_NAMEs: KERNAN, KATHRYN  (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: activation product;Address;Adopted;Adult;Age;Anemia;Award;biobank;Bioinformatics;bioinformatics resource;Biological Markers;career;Caring;Cell Communication;Cell Physiology;central nervous system injury;Cessation of life;Characteristics;Child;Childhood;Childhood Injury;Clinical;Clinical Trials;Code;cohort;Complement;Complement Activation;congenital immunodeficiency;cost;Critical Care;Critically ill children;cytokine;cytopenia;cytotoxic;Cytotoxic T-Lymphocytes;Data Science;Data Set;Databases;Defect;Development;Diagnosis;Disease;Endothelium;Enrollment;exome sequencing;Experimental Designs;Foundations;Functional disorder;Future;Genetic;genetic epidemiology;Genetic Risk;genetic variant;Genetic Variation;Genomic approach;genomic data;Genomic medicine;Genomics;Genotype;Hemolytic-Uremic Syndrome;Hemophagocytic Lymphohistiocytoses;Hepatic;Hepatobiliary;Heritability;high risk;Hospitalization;Household;Immune;Immune System Diseases;Immunologics;Immunophenotyping;immunoregulation;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;K-Series Research Career Programs;Knowledge;Laboratories;Link;Macrophage;Measurement;Mentored Clinical Scientist Development Program;Mentors;Mentorship;mortality;mortality risk;Multi-Institutional Clinical Trial;Multiple Organ Failure;Natural Killer Cells;next generation sequencing;novel;offspring;Organ;Organ failure;organ growth;organ injury;Outcome;Parents;Participant;Pattern;pediatric sepsis;personalized approach;Phenotype;population based;prospective;Prospective cohort;protein biomarkers;rare variant;Research;Research Design;Risk;risk variant;Sepsis;septic;Septic Shock;Site;skills;Subgroup;T-Lymphocyte;Testing;therapeutic target;Thrombocytopenia;Thrombocytopenic Purpura;thrombotic;Thrombotic Thrombocytopenic Purpura;Training;Validation;Variant;Work

PROJECT_TITLE: Genetic Variants of Immune Dysregulation and Thrombotic Microangiopathy in Severe Pediatric Sepsis Induced Organ Dysfunction

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Microbiome;Nutrition

ORG_CITY: Columbus

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The gut microbiome affects many aspects of human health including aging and response to cancer treatments. Though the microbiome is malleable, we lack the knowledge to rationally manipulate it to modify older adults’ treatment response. This project will define the microbiomes of older adults with lung cancer who best respond to immunotherapy treatment, and use dietary interventions and preclinical models to define how to manipulate the microbiome to increase healthspan.

PI_NAMEs: SPAKOWICZ, DANIEL J. (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Acceleration;advanced disease;Affect;Age;age effect;age related changes;Aging;anti-cancer research;Antineoplastic Agents;Award;Bacteria;Bifidobacterium;Biological Markers;Black Raspberry;cancer care;cancer cell;cancer immunotherapy;Cancer Model;Cancer Patient;cancer therapy;care outcomes;Clinical;clinical practice;Clinical Trials;Collection;Comprehensive Cancer Center;Computer Models;Consumption;Cross-Over Trials;Data;Dedications;density;Diet;Dietary Intervention;Eating;Elderly;empowerment;Enrollment;experience;Food;Generations;Geriatrics;Goals;gut microbiome;Health;Health Promotion;healthspan;Human;Human Microbiome;immune checkpoint blockade;Immune system;Immunotherapy;improved;Individual;Intervention;Intervention Studies;Investigation;Knowledge;Link;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mentored Research Scientist Development Award;Mentorship;Methods;Microbe;microbial;microbial composition;microbiome;microbiome therapeutics;Modification;Mus;new therapeutic target;Non-Small-Cell Lung Carcinoma;nutrition;Ohio;older adult;Oncology;Outcome;Patients;Placebo Control;Placebos;Play;polyphenol;Population;post intervention;Pre-Clinical Model;Randomized;Research Personnel;response;response biomarker;Role;Sampling;Testing;Therapeutic;therapeutic target;Time;Training;Treatment Protocols;treatment response;Universities;Work

PROJECT_TITLE: The microbiome  in  older  adults  with lung cancer: association of treatment regimens and diet with protective microbial profiles

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease

PI_NAMEs: BHAN, ATUL K (contact)

PROJECT_TERMS: Achievement;adaptive immunity;Appointment;Area;Award;base;Biology;Cells;Charge;Chemicals;Classification;Clinical Research;clinical translation;Collaborations;Development;Digestive System Disorders;Disease;Educational workshop;Eligibility Determination;Faculty;Fostering;Funding;Funding Agency;General Hospitals;Goals;Grant;Growth;gut microbiome;Health;high risk;Human Genetics;Inflammatory Bowel Diseases;innovation;Investigation;Israel;Journals;Laboratory Research;Letters;Massachusetts;Medical center;medical schools;meetings;member;Mission;Natural Immunity;novel;Patients;Peer Review;Physiological;Pilot Projects;Postdoctoral Fellow;programs;Public Health Schools;Publishing;recruit;Reporting;Research;Research Personnel;Resources;Science;Scientist;success;Systems Biology;Therapeutic;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: Pilot & Feasibility Program


PROJECT_TERMS: Alleles;Assisted Reproductive Technology;Binding;Binding Sites;Bromodomain;Chromatin;Chromatin Structure;Chromosome Pairing;Complex;Data;Defect;Development;Differentiated Gene;DNA Packaging;DNA Polymerase II;Ensure;Environment;Equus caballus;Event;Failure;Fertility;Gene Expression Profile;Gene Expression Regulation;gene repression;Gene Silencing;Genes;genetic corepressor;Genetic Recombination;Genetic Transcription;Genome;Genome Mappings;genome-wide;Histone Acetylation;Histones;Human;Immunofluorescence Immunologic;Infertility;insight;Knockout Mice;Machine Learning;male;male fertility;Male Infertility;Mediating;Meiosis;Meiotic Prophase I;men;Modeling;Molecular;molecular subtypes;Morphogenesis;Morphology;Mus;mutant;Mutant Strains Mice;Mutation;Nature;Nuclear;Pathway interactions;Pattern;Play;Process;Production;promoter;Protamines;protein function;Proteins;recruit;Repression;Role;Sampling;Seminal fluid;sperm analysis;sperm cell;Sperm Head;sperm morphology;sperm viability;Spermatids;Spermatocytes;Spermatogenesis;Spermiogenesis;SPO11 gene;Stratification;Testing;Testis;Time;tool;Transcriptional Regulation

PROJECT_TITLE: Investigating the role of bromodomain-containing proteins in the production of viable spermatozoa and male fertility


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Neurodegenerative;Neurosciences;Nutrition;Women's Health Research

ORG_CITY: Fort Lauderdale-Davie

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NOVA SOUTHEASTERN UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE Nilotinib is an FDA-approved chemotherapeutic agent that has also been recently shown to improve mitochondrial bioenergetics and attenuate hallmark biomarkers in Alzheimer’s disease (AD) transgenic mouse models. However, nilotinib’s specific effects based on sex are largely unknown. Furthermore, since, a high fat diet (HFD) exacerbates AD pathophysiology, we propose to test nilotinib in 3xTg AD mice on an HFD to investigate sex-based differences on bioenergetic and AD-related neuropathological outcomes.

PI_NAMEs: ALBENSI, BENEDICT C (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: 3xTg-AD mouse;AD transgenic mice;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid;Amyloid beta-Protein;Animal Model;Appearance;Astrocytes;Attenuated;Behavioral;Bioenergetics;Biological Markers;cerebrovascular health;chemotherapeutic agent;Clinical Trials;clinically relevant;Cognition;Cognitive;cognitive enhancement;cognitive function;comorbidity;Cultured Cells;Data;Dementia;Disease;Disparity;Exhibits;FDA approved;Female;Functional disorder;Genus Hippocampus;Goals;Heart;High Fat Diet;Impaired cognition;improved;improved outcome;in vivo;Individual;Inflammation;Inflammatory;insight;Knowledge;leukemia;Link;male;Medical;Memory;men;Metabolic;Metabolic Diseases;Metabolism;Methods;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular;morris water maze;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuropathology;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;object recognition;OPA1 gene;Outcome;Oxidative Stress;Oxygen Consumption;Pathology;patient population;Patients;Pharmaceutical Preparations;phase 2 study;phase III trial;Prediabetes syndrome;Process;protein expression;Publications;Rodent Model;sex;Sex Bias;Sex Differences;tau Proteins;Testing;Treatment outcome;Unhealthy Diet;white matter;Woman;Work

PROJECT_TITLE: Sex-based differences of a high fat diet in Alzheimer's disease (AD): Can nilotinib reverse bioenergetic and neuropathological deficits?


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: GENEVA

ORG_COUNTRY: SWITZERLAND

ORG_FIPS: SZ

ORG_NAME: ICH

PHR: Geneva, 1 October 2020 Funding Opportunity RFA-FD-21-002 Narrative  International Council for Harmonisation of Technical Requirements for Pharmaceuticals for  Human Use The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) works to promote public health through international harmonisation of technical requirements that contributes to the timely introduction of new medicines and continued availability of the approved medicines to patients, to the prevention of unnecessary duplication of clinical trials in humans, to the development, registration and manufacturing of safe, effective, and high quality medicines in an efficient and cost-effective manner, and to the minimisation of the use of animal testing without compromising safety and effectiveness.

PI_NAMEs: MACARA, EMILIE  (contact)

PROGRAM_OFFICER_NAME: ADLEBERG, JILL


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome

PROJECT_TERMS: adaptive immunity;Administrator;Applied Research;Area;Awareness;Back;Basic Science;Boston;Budgets;Cells;Clinical;Collaborations;Communicable Diseases;Communication;Communities;Complex;Data;Development;Digestive System Disorders;Disease;Disease susceptibility;Educational workshop;Ensure;Environment;Environmental Risk Factor;Epidemiologist;Event;Extramural Activities;Feedback;Food Hypersensitivity;Fortification;Fostering;Gastroenterology;General Hospitals;Genes;Genetic;Genomics;Goals;Health;Human;Human Genetics;Human Microbiome;Immune;Immunity;Immunologist;Immunology;Inflammatory Bowel Diseases;Informatics;insight;Institution;International;intestinal epithelium;Intestinal Mucosa;Massachusetts;Medical Genetics;Medicine;meetings;member;Metabolism;Microbe;microbiome;microorganism interaction;Mission;Molecular;Molecular Genetics;Mucous Membrane;multidisciplinary;Natural Immunity;Pathogenesis;Patients;Population Genetics;Productivity;programs;Proteins;Recommendation;recruit;Research;Research Personnel;Role;Scientist;Series;Signal Transduction;symposium;System;targeted treatment;Techniques;Technology;Therapeutic;Training and Education;Travel;Visit;Work

PROJECT_TITLE: Enrichment Program


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Spinal Muscular Atrophy

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative This proposal takes advantage of innovative model systems to address connections between eukaryotic chromosome packaging, ribonucleoprotein assembly and pre-messenger RNA processing. Work here is expected to fundamentally advance our understanding of epigenetic gene regulation and neuromuscular development, providing critical insight into molecular mechanisms that drive Cancer and Spinal Muscular Atrophy in humans.

PI_NAMEs: MATERA, A. GREGORY  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Alleles;Amino Acids;Animal Model;Animals;Binding;Biochemistry;Biogenesis;Biological Models;Biological Process;Cells;Chromatin;Chromosomes;Development;Drosophila melanogaster;Epigenetic Process;Eukaryota;gene conservation;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genome;genome-wide;Histones;Housekeeping;Human;Individual;innovation;insight;interest;Laboratories;Malignant Neoplasms;messenger ribonucleoprotein;Messenger RNA;Missense Mutation;model organism;Modeling;Molecular;Molecular Genetics;Motor Neurons;Multigene Family;mutant;Mutation;neuromuscular;Neuromuscular Diseases;Pathway interactions;Patients;Play;Post-Translational Protein Processing;Process;Research;Ribonucleoproteins;RNA Processing;Role;Series;Small Nuclear Ribonucleoproteins;Spinal Muscular Atrophy;Spliceosomes;survival motor neuron gene;Techniques;Time;Tissues;Transcript;transmission process;Work

PROJECT_TITLE: Ribonucleoprotein Biogenesis and Epigenetic Gene Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


PI_NAMEs: GRIMSON, ANDREW W (contact)

PROJECT_TERMS: 3' Untranslated Regions;Address;Affect;Alleles;asthenospermia;base;Bioinformatics;Biological Assay;candidate identification;Cell Culture Techniques;Cell Line;Cells;Chromatin;Clinical;Complex;Conserved Sequence;Data;Data Set;Defect;Developed Countries;Development;Ejaculation;Elements;Epigenetic Process;Exhibits;exome;experimental study;Fertility;fitness;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic regulatory protein;Genetic Transcription;Genome;Haploidy;Health;Human;In Vitro;Individual;Infertility;Length;Lesion;Male Infertility;mammalian genome;Mastigophora;Measures;men;Messenger RNA;Modeling;Molecular;Morphology;Motility;mouse model;mRNA Stability;mRNA Translation;Mus;Mutation;Nature;Organism;particle;Pathogenicity;Patients;Phenotype;Phylogeny;Play;Polyadenylation;Population;Post-Transcriptional Regulation;Post-Transcriptional RNA Processing;posttranscriptional;Process;Protein Isoforms;Proteins;recruit;Regulation;Regulatory Element;Reporter;Reporter Genes;reproductive;Ribosomes;RNA;RNA Stability;Role;screening;segregation;Seminal fluid;Single Nucleotide Polymorphism;Site;Source;Specific qualifier value;sperm cell;Sperm Count Procedure;sperm function;sperm morphology;Spermatids;Spermatocytes;Spermatogenesis;Spermiogenesis;System;Testing;Testis;trafficking;Transcript;transcriptome sequencing;translational impact;Translations;United States;Untranslated RNA;Variant;whole genome;Wild Type Mouse

PROJECT_TITLE: Impact of 3' untranslated region sequence variants in spermiogenic gene expression and infertility


NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Focal cortical dysplasia (FCD) is a common cortical malformation associated with medically refractory epilepsy and most frequently caused by variants in subunits of the GATOR1 complex (a negative regulator of mTOR): DEPDC5, NPRL3, and NPRL2. The least studied of these variants is NPRL2 and in this proposal we aim to define the pathophysiological consequences of Nprl2 KO in vivo and in vitro. Using a mouse model of FCD we will define the morphological and functional changes that occur due to Nprl2 KO-induced mTOR pathway hyperactivation as well as investigate the transcriptomic changes that occur downstream of mTORC1 that may produce MCD and seizures.

PI_NAMEs: IFFLAND, PHILIP HENRY (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;AKT3 gene;Amino Acids;Animals;Architecture;autism spectrum disorder;Binding;Biological Assay;brain malformation;brain tissue;Cell Aggregation;cell cortex;Cell Size;cell type;Cells;Cellular Morphology;Cerebral cortex;Childhood Neurological Disorder;Complex;Cortical Dysplasia;Cortical Malformation;CRISPR/Cas technology;Defect;Dendrites;Dependence;Development;Developmental Delay Disorders;differential expression;Disease;Dissociation;EIF4EBP1 gene;Electroencephalography;Electroporation;Ephrin-A5;Epilepsy;experimental study;Fluorescence;FRAP1 gene;Future;Genes;genetic variant;Growth;Harvest;Image;Image Cytometry;Immunochemistry;immunocytochemistry;in utero;In Vitro;in vivo;Individual;Intellectual functioning disability;Intractable Epilepsy;Knowledge;Lesion;Link;Lysosomes;Manuals;Measurement;Medical;Modeling;Monitor;Morphology;mouse model;mTOR Inhibitor;mTORopathies;Mus;Neurodevelopmental Disorder;neuronal cell body;Neurons;new therapeutic target;novel;Operative Surgical Procedures;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphorylation;PIK3CG gene;Plasmids;pre-clinical;Precision therapeutics;preclinical study;Process;Protein Subunits;Proteins;Proto-Oncogene Proteins c-akt;pup;Regulator Genes;Resected;Resistance;response;Role;Seizures;Signal Transduction;single nucleus RNA-sequencing;Sirolimus;Somatic Mutation;Specimen;Starvation;STAT3 gene;Structure;Testing;transcriptome;transcriptomics;TSC2 gene;Variant;Western Blotting

PROJECT_TITLE: The role of NPRL2 loss in focal cortical dysplasia

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Pediatric;Pediatric - AIDS;Rare Diseases;Tuberculosis

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Public Health Statement: Pediatric TB is underdiagnosed and has a high mortality rate. Promising new diagnostics have been developed but not sufficiently evaluated in children less than 5 years of age, those at greatest risk. We propose a comprehensive study of children from Uganda suspected to have TB that should result in more accurate rapid and non-invasive diagnosis of TB

PI_NAMEs: ALLAND, DAVID ;ELLNER, JERROLD J. (contact);SALGAME, PADMINI

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: 5 year old;Address;Adult;Age Years;Bacteria;Bacteriology;biobank;Biological Assay;Biological Markers;biomedical referral center;Body Fluids;Boston;C-reactive protein;Case Fatality Rates;cell free DNA;Centers for Disease Control and Prevention (U.S.);Child;Childhood;Classification;Clinical;Clinical Trials;cohort;Collection;Country;cytokine;Death Rate;deep sequencing;detection assay;Diagnosis;Diagnostic;diagnostic accuracy;Drug resistance;Feces;Foundations;frontier;Gene Expression Profile;genome sequencing;Genomics;Goals;HIV;HIV Infections;Immune response;innovation;Kenya;laboratory facility;lateral flow assay;lipoarabinomannan;Medical Research;Mycobacterium tuberculosis;nano-string;Nature;next generation;noninvasive diagnosis;novel;novel diagnostics;novel strategies;Observational Study;oropharyngeal swab;Plasma;Plasma Cells;point of care;point of care testing;Probability;Prospective Studies;Public Health;rapid diagnosis;Reference Standards;Research Institute;Research Personnel;respiratory;response;Risk;Sampling;Science;Signal Transduction;Specificity;Specimen;stool sample;Stratification;study population;Symptoms;T-Cell Activation;Testing;Translations;Tuberculosis;Tuberculosis diagnosis;tuberculosis treatment;Uganda;Universities;Validation;Whole Blood;whole genome

PROJECT_TITLE: Novel and Optimized Diagnostics for Pediatric TB

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-B(07)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Opioid Misuse and Addiction;Opioids;Pediatric;Pregnancy;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative- Public Health Relevance Statement The proposed research is relevant to public health because of the high rates of opioid use disorder among pregnant people in jail and the need to provide evidence-based treatment in order to optimize maternal and infant outcomes. This project is relevant to NIDA's strategic goals to increase access to opioid use disorder treatment for jail populations, who are at high risk of adverse outcomes, and, with NIDA's recently established Racial Equity Initiative, to address racial inequities in substance use treatment. By conducting research and building partnerships with directly impacted individuals and jail policy leaders, we will promote implementation and dissemination of evidence based treatment for pregnant, incarcerated people that will improve outcomes for them and their children.

PI_NAMEs: SUFRIN, CAROLYN  (contact)

PROGRAM_OFFICER_NAME: MULFORD, CARRIE FRIED

PROJECT_TERMS: Address;Admission activity;Adoption;adverse outcome;Advocacy;aged;Caring;Categories;Child;Child Rearing;clinical care;Collaborations;Communities;community partners;correctional system;Counseling;Data;design;Discipline of obstetrics;Dissemination and Implementation;Drug user;Education;effectiveness/implementation study;effectiveness/implementation trial;Elements;Ensure;Environment;Equity;Evidence based treatment;experience;Feedback;Focus Groups;Fright;Funding;Future;Geography;Goals;Health;health care delivery;health inequalities;Health Services Accessibility;high risk;Human;implementation framework;implementation measures;implementation strategy;Imprisonment;improved;improved outcome;Individual;Infant;Infant Health;infant outcome;innovation;intergenerational;Intervention;Jail;Justice;Legal system;Life;marginalization;Maternal Health;Maternal health equity;maternal outcome;Medical;medication for opioid use disorder;Mental Health;Methodology;Mothers;National Institute of Drug Abuse;Nature;Newborn Infant;Opioid;opioid epidemic;opioid use disorder;Outcome;Outcome Measure;overdose death;Overdose reduction;parole;patient oriented;Patient-Centered Care;Patient-Focused Outcomes;people of color;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;Play;Policies;Population;Pregnancy;Pregnancy Outcome;pregnant;Prenatal care;probation;programs;Provider;psychosocial;Public Health;public health relevance;racial disparity;Racial Equity;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recidivism;Recovery;recruit;relapse risk;reproductive;Research;Research Personnel;Resources;Role;Sampling;scale up;service providers;Services;Shapes;Site;social stigma;social structure;standard of care;substance use treatment;Surveys;System;Testing;Time;tool;Training;Treatment outcome;Withdrawal;Woman;Work

PROJECT_TITLE: Expanding Access to Pregnancy Specific Opioid Use Disorder Treatment in Jail: Piloting and Adaptable Implementation Strategy to Advance Equitable and Patient-Centered Care

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


PI_NAMEs: JAFFREY, SAMIE R (contact)

PROJECT_TERMS: 3' Untranslated Regions;Address;Adenosine;Affect;Affinity;Animals;Binding;Binding Proteins;cell type;Cells;Characteristics;Chromatin;Cytidine;Cytidine Deaminase;Data;Deamination;Defect;Development;Distal;Enzymes;Epigenetic Process;epigenetic regulation;epigenetic silencing;epigenome;epitranscriptome;epitranscriptomics;Exhibits;experimental study;Gene Expression Regulation;Genetic Transcription;genomic locus;Genomics;Germ Cells;Human;Impairment;Induction of Apoptosis;Infertility;insight;Knock-out;Length;link protein;Maps;Mediating;Meiosis;Messenger RNA;Methods;Methyltransferase;Modification;mouse development;mRNA Stability;mRNA Transcript Degradation;mRNA Translation;Mus;Mutation;Nucleotides;Patients;Pattern;Pharmaceutical Preparations;Polyadenylation;Positioning Attribute;Process;Proteins;Reader;recruit;Regulation;ribosome profiling;RNA;RNA Binding;RNA Splicing;Role;Sampling;Series;Site;small molecule;sperm cell;sperm morphology;Sperm Motility;Spermatids;Spermatocytes;Spermatogenesis;stem cell differentiation;stoichiometry;Testis;Time;transcriptome;Translational Regulation;Translations;Untranslated RNA;Zygonema

PROJECT_TITLE: Epitranscriptomic control of mRNA and noncoding RNAs in spermatogenesis


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease

ORG_CITY: COLUMBIA

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Nonalcoholic fatty liver disease (NAFLD) has become a global epidemic with its progression to nonalcoholic steatohepatitis (NASH; hepatic inflammation) and fibrosis resulting in increased cardiovascular disease mortality and the development of hepatocellular carcinoma. A poor understanding of the underlying causes of NASH and fibrosis has severely limited the development of effective therapeutic and preventative strategies. The project will examine the novel relationship between hepatocyte, Kupffer cell and hepatic stellate cell RECK (Reversion Inducing Cysteine Rich Protein with Kazal Motifs) and the regulation of NASH and fibrosis with outcomes that will improve our understanding of the mechanisms responsible for NASH and highlight potential therapeutic targets for the future treatment of the disease.

PI_NAMEs: BYSANI, CHANDRASEKAR ;RECTOR, RANDY SCOTT (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Amino Acid Motifs;Amphiregulin;Anti-Inflammatory Agents;Attenuated;Cardiac;Cardiovascular Diseases;Cardiovascular system;cell injury;Cell Separation;cell type;Cells;chemokine;Cholesterol;Clinical;Coculture Techniques;Cre-LoxP;cysteine rich protein;cytokine;Data;Deposition;Development;Disease;Disintegrins;Down-Regulation;Ectopic Expression;Embryo;Enterobacteria phage P1 Cre recombinase;Epidemic;Epidermal Growth Factor Receptor;Extracellular Matrix;Fatty acid glycerol esters;Fibroblasts;Fibrosis;Future;gain of function;Gene Deletion;Genes;Genetic;GPI Membrane Anchors;Growth Factor;Healthcare;Hepatic;Hepatic Stellate Cell;Hepatocyte;hepatoprotective;improved;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;innovation;Intervention;Investigation;knock-down;Kupffer Cells;Ligands;Liver;Liver diseases;Liver Fibrosis;liver inflammation;loss of function;LoxP-flanked allele;Macrophage;Mediating;Mediator;Membrane;Metalloproteases;migration;Molecular;Molecular Analysis;mortality;mouse model;Mouse Strains;Mus;Myofibroblast;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Organ;Outcome;overexpression;Pathogenesis;Pathway interactions;Patients;pharmacologic;Phenotype;Pilot Projects;Play;pre-clinical;Prevention strategy;Primary carcinoma of the liver cells;Process;Production;protein expression;Proteins;Receptor Activation;receptor-mediated signaling;Regulation;Reporting;Role;Severities;Signal Transduction;Sucrose;System;Testing;Therapeutic;therapeutic target;therapeutically effective;Transgenic Mice;Transgenic Organisms;western diet

PROJECT_TITLE: RECK regulation of NASH and fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(03)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Complementary and Integrative Health;Down Syndrome;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Rural Health;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: MCKINNEY, CHRISTY MICHELLE (contact)

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: Alaska;Award;Behavioral Sciences;career;career development;Child;Clinical;Clinical Research;Clinical Sciences;cohort;Collaborations;collaborative environment;Communities;Competence;Complex;disability;Discipline;Disease;Doctor of Philosophy;early-career faculty;Educational Curriculum;Environment;Ethnic Origin;experience;Faculty;Fred Hutchinson Cancer Research Center;Funding;Goals;Health;Human;Idaho;improved;innovation;Institution;investigator training;Lead;Mentors;Mentorship;Montana;multidisciplinary;next generation;novel;outreach;peer;Positioning Attribute;Preventive measure;Program Development;programs;Publications;Race;recruit;Research;Research Personnel;rural area;Rural Health;rural underserved;Scientist;social;social disparities;Social Sciences;Talents;Time;Training;translational health science;Translational Research;translational scientist;Underserved Population;United States National Institutes of Health;Universities;Wages;Washington;Work;Wyoming

PROJECT_TITLE: Institutional Career Development Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Impaired macrophage efferocytosis drives important diseases including atherosclerosis, whereas enhancing efferocytosis has therapeutic benefits. We have established a genome-wide CRISPR screen for unbiased discovery of novel regulators of macrophage efferocytosis. This study will focus on Wdfy3, a novel regulator discovered by the screen, for in-depth mechanistic studies on its molecular mechanisms and roles in atherosclerosis.

PI_NAMEs: ZHANG, HANRUI  (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Acute;Address;Apoptosis;Apoptotic;Arterial Fatty Streak;Atherosclerosis;Autophagocytosis;Binding;Biological Process;Bone Marrow;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR screen;Data;Dependence;Dexamethasone;Disease;Eating;Event;Genes;genome wide screen;genome-wide;Goals;Guide RNA;Human;human induced pluripotent stem cells;Impairment;In Vitro;in vivo;Individual;induced pluripotent stem cell;Inflammation;innovation;insight;interest;knock-down;Knock-in;Knock-out;Knowledge;Lysosomes;Macrophage;Mediating;Molecular;mouse model;Mus;mutation carrier;Myelogenous;novel;null mutation;nutrient deprivation;overexpression;Pathway interactions;Performance;Phagocytes;Phagocytosis;Phagosomes;Phenotype;protein aggregation;Proteins;recruit;Regulation;Role;seal;Small Interfering RNA;Starvation;Testing;Therapeutic;therapeutic target;Thymus Gland;Validation;WD Repeat

PROJECT_TITLE: Discovering Wdfy3 as a novel regulator of macrophage efferocytosis by genome-wide CRISPR screen

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: NARRATIVE More than 21 million people in the world suffer from schizophrenia, and they experience a wide variety of symptoms that include distorted perception, such as hallucinations, and disrupted social information processing. This proposal uses naturalistic videos along with two complementary neuroimaging methods to examine how perceptual deficits in schizophrenia, specifically in the language domain, might influence social processing deficits. Understanding the neural correlates of language and social processing during naturalistic stimuli will be a step forward towards finding biomarkers of severe mental illness and ultimately improving patient care.

PI_NAMEs: PRZYSINDA, EMILY JOYCE DOYLE (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Address;Area;Behavior;Biological Markers;Brain;Brain region;care outcomes;career;clinical training;Cognition;Complex;cost;Data;Disease;Electroencephalography;Elements;Event;experience;Frequencies;Functional impairment;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Future;Hallucinations;Healthcare;imaging modality;Imaging Techniques;Impairment;improved;Individual;information processing;interest;Language;language processing;Life;Linear Models;Linguistics;Measures;Medical;mental state;Mentorship;Methods;movie;neural;neural correlate;neural model;neural network;neuroimaging;neurophysiology;neurotransmission;Participant;Patient Care;Patient-Focused Outcomes;Patients;Perception;Persons;Pharmaceutical Preparations;Physicians;Process;Property;Quality of life;recruit;Research;response;Role;Schizophrenia;Scientist;Sensory;severe mental illness;side effect;social;social communication;social deficits;social influence;Social Interaction;social norm;Speech;Speech Acoustics;Stimulus;success;Symptoms;Techniques;temporal measurement;theory of mind;Time;Training;Training Programs

PROJECT_TITLE: Neurophysiology of social processing and underlying perceptual deficits in schizophrenia


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness;Social Determinants of Health;Violence Research

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Project Narrative Childhood sexual abuse has been associated with increased risk for psychopathology, revictimization, and health-damaging behavior in adulthood but the neurobiological mechanisms underlying these outcomes remain largely unknown. The overarching goals of this competing renewal are to (1) improve our mechanistic understanding of oxidative stress mechanisms in these processes risk; (2) investigate links between these mechanisms and two key phenotypes of depression; and (3) identify biobehavioral markers predicting disease course and functioning in the context of childhood sexual abuse. A better understanding of neurobiological underpinnings of abuse-related outcomes will contribute to developing more targeted therapeutic interventions, identifying individuals at risk for psychopathology at a younger age, and preventing revictimization.

PI_NAMEs: DU, FEI  (contact);PIZZAGALLI, DIEGO A

PROGRAM_OFFICER_NAME: BORJA, SUSAN EILEEN

PROJECT_TERMS: 14 year old;Adolescence;Adult;Adult women;Affect;Age;Anhedonia;Animals;Award;Behavior;Behavior Control;Behavioral;biobehavior;Bioenergetics;Brain;Brain region;Child;Child Sexual Abuse;childhood adversity;cognitive control;Cognitive deficits;Communities;Computer Models;Corpus striatum structure;Coupled;cytokine;Data;Depressed mood;depressive symptoms;design;Diagnosis;Disease;Disease remission;disorder risk;dopamine transporter;early life adversity;early life stress;epidemiologic data;epidemiology study;Equilibrium;experience;Exposure to;Female;follow up assessment;follow-up;Frequencies;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;Future;Glutamates;Glutamine;Glutathione;Goals;Health;Hippocampus;Human;imaging approach;improved;in vivo;Individual;Inflammatory;inflammatory marker;Learning;Life;Link;Magnetic Resonance Spectroscopy;Major Depressive Disorder;maladaptive behavior;Maps;Medial;meetings;Mental Depression;Mental disorders;Molecular;molecular imaging;morphometry;neural correlate;neurobiological mechanism;Neurobiology;neuronal circuitry;NMR Spectroscopy;nonhuman primate;novel;Outcome;Oxidation-Reduction;Oxidative Stress;Participant;Pathway interactions;Phenotype;physical abuse;pre-clinical;pre-clinical research;predictive marker;Prefrontal Cortex;prevent;Process;prospective;prospective test;Psychopathology;Recording of previous events;Regulation;Reporting;revictimization;Rewards;Risk;Rodent;Role;Sampling;Stress;Stressful Event;Structural defect;Substance abuse problem;Symptoms;targeted treatment;Techniques;Testing;Therapeutic Intervention;Thick;Thinness;Time;Transcriptional Regulation;United States Dept. of Health and Human Services;Woman;young adult

PROJECT_TITLE: Early Life Stress and Depression: Molecular and Functional Imaging Approaches

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Genetics;Infertility;Pediatric;Rural Health;Social Determinants of Health

PI_NAMEs: LIN, DAVID M. (contact)

PROJECT_TERMS: Applications Grants;Area;Asexual Reproduction;Bacteria;Biological Sciences;Breeding;Canis familiaris;Cells;college;Communication;Communities;Creativeness;design;Development;Education;Education and Outreach;Educational process of instructing;falls;Foundations;Funding;Gene Expression Regulation;Genetic Variation;girls;Goals;graduate student;Grant;Infertility;innovation;junior high school;K-12 student;Learning;Locales;Low income;Middle School Student;Mitosis;New York;Organism;outreach;outreach program;Parents;Participant;programs;Records;recruit;Reproduction;Reproductive Biology;Rural;Rural Community;school district;Schools;Science;Sexual Reproduction;skills;Source;STEM career;student participation;Student recruitment;Students;Time;trait;Visit;Work

PROJECT_TITLE: Education and Outreach Core C


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Narrative Precise control of adipose tissue function is crucial in modulating energy balance and glucose homeostasis. This research project will test novel concepts that molecularly distinct subsets of VMH SF1 neurons modulate white adipose tissue lipolysis and brown adipose tissue thermogenesis through different sympathetic circuit pathways, and that Ca2+-permeable AMPA receptor (CP-AMPAR) and tumor necrosis factor-a (TNFa) signals in VMH SF1 neurons contribute to the development of high-fat diet (HFD)-induced obesity (DIO). The information to be collected from this project will reveal expression of specific genes in VMH SF1 neurons modulating iWAT or iBAT, and demonstrate that attenuating CP-AMPAR and TNFa signals in VMH SF1 neurons can be an attractive strategy for the treatment of DIO in HFD-fed mice.

PI_NAMEs: YANG, YUNLEI  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Acclimatization;Action Potentials;Acute;adeno-associated viral vector;Adipose tissue;AMPA Receptors;blood glucose regulation;Brain;brain control;Brown Fat;cell type;Central Nervous System;combat;comorbidity;Cytoplasm;Data;Development;diet-induced obesity;Electrophysiology (science);energy balance;Energy Metabolism;enhancing factor;excitotoxicity;Expenditure;experimental study;factor A;feeding;Gene Expression;Generations;Genes;Genetic;Genetic Transcription;Glucose;glucose tolerance;Glutamate Receptor;Head;High Fat Diet;Hypothalamic structure;inflammatory marker;innovation;Insulin;knock-down;Label;Leptin;Lipolysis;Literature;Logic;Maps;Mediating;Messenger RNA;Metabolic;Methods;midbrain central gray substance;Molecular;Mus;neural circuit;Neurons;Neurosciences;Neurotransmitter Receptor;neurotransmitter release;Norepinephrine;novel;Obesity;obesity development;obesity prevention;Pathologic;Pathway interactions;Peripheral;Permeability;Phosphorylation;Photometry;Physiological;Play;Population;prevent;Probability;receptor;receptor expression;Receptor Signaling;Regulation;Research Project Grants;Role;satiety center;Series;SF1;Signal Transduction;single-cell RNA sequencing;Site;Slice;sterol esterase;Synapses;Techniques;Temperature;Testing;Thalamic structure;Therapeutic Intervention;Thermogenesis;Time;Tissues;TNF gene;TNFRSF1A gene;Transgenic Mice;transmission process;treatment strategy;Tumor Necrosis Factor Receptor;Weight Gain

PROJECT_TITLE: VMH SF1 neurons-originated sympathetic circuits modulating iWAT and iBAT

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


PI_NAMEs: GRENIER, JENNIFER K (contact)

PROJECT_TERMS: analysis pipeline;Antibodies;ATAC-seq;Bar Codes;base;Biological;Biological Assay;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Collection;combinatorial;Communities;community building;Consultations;cost effective;Custom;Data Analyses;data quality;Development;DNA;DNA Sequencing Facility;Ensure;Enzymes;epigenomics;Equipment Design;Experimental Designs;Expression Profiling;Fee-for-Service Plans;Financial Support;flexibility;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Generations;genomic profiling;Genomics;Group Meetings;Histones;Home;Immunoprecipitation;indexing;Individual;Infertility;innovation;laboratory development;Libraries;Literature;Methodology;Methods;Names;novel;Oligonucleotides;operation;Preparation;Protocols documentation;Reagent;reproductive;Reproductive Technology;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;RNA;RNA analysis;RNA methylation;Sampling;Services;single cell genomics;Small RNA;technological innovation;technology development;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;Transposase;Update

PROJECT_TITLE: Genomics Innovation Core B


NIH_SPENDING_CATS: Clinical Research;Genetics;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LA JOLLA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Acute lung injury as a result of the systemic inflammatory response (SIRS) is a common cause of complications in patients following severe injury. Unfortunately, therapeutics that limit SIRS after injury are lacking, with poor translation of therapeutics from animal models into patients in the clinical setting. Here, we will identify the function and mechanism of action of uniquely human genes that are highly expressed in monocytes/macrophages, define their contribution to human SIRS, and understand how these genes effect therapeutics that target anti-inflammatory signaling pathways.

PI_NAMEs: COSTANTINI, TODD W (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acute Lung Injury;alpha-bungarotoxin receptor;Animal Model;Anti-Inflammatory Agents;Burn injury;Cells;Cessation of life;cholinergic;Clinical;Clinical Research;Development;Functional disorder;Gene Expression;gene function;Genes;genetic approach;Goals;Human;human induced pluripotent stem cells;Immune;Immune response;Immune system;induced pluripotent stem cell;Inflammatory;injured;Injury;Lung;Macrophage;Mediating;Modeling;monocyte;Multiple Organ Failure;Mus;novel;novel therapeutic intervention;Organ;Patients;Phenotype;pre-clinical research;programs;Research;response;response to injury;Role;Sampling;severe burns;severe injury;Signal Pathway;Signal Transduction;System;systemic inflammatory response;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Transgenic Mice;translational therapeutics;Trauma;Variant

PROJECT_TITLE: Mechanism of action of uniquely human genes in the injury response


ORG_CITY: SHREVEPORT

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health given our lack of understanding of the processes underlying brain repair following stroke, lack of reparative treatments, and high rates of stroke-related disabilities among survivors. Investigation of the inherent neurogenic capacity for neuronal replacement and the mechanisms that underlie functional recovery is critical to the development of novel therapies for the treatment of stroke.

PI_NAMEs: RODGERS, KRISTA  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Acute;Address;Adolescent;Adult;adult neurogenesis;age difference;age related;antagonist;Anti-Inflammatory Agents;Behavioral;Biological Assay;Brain;Brain Injuries;brain repair;Child;Childhood;Chronic;Chronic Phase;Corpus striatum structure;Coupled;designer receptors exclusively activated by designer drugs;Development;Developmental Process;disability;Electrophysiology (science);Environment;Exhibits;functional outcomes;Generations;Genetic;glial activation;Goals;Grant;Human;Immune response;immunoregulation;Impairment;improved;in vivo;Inflammatory;Injury;injury recovery;innovation;Interleukin-13;Interleukin-4;Investigation;Ischemia;Ischemic Stroke;Knowledge;Label;Life;Long term disability;Macrophage Colony-Stimulating Factor Receptor;Mammals;Microglia;Middle Cerebral Artery Occlusion;Modeling;Molecular;motor recovery;mouse model;Mus;Neonatal;neonate;Nerve Block;Nerve Regeneration;nerve stem cell;neural network;neural repair;neurobehavioral test;neurogenesis;Neuroimmune;neuron regeneration;neuronal replacement;neuronal survival;Neurons;newborn neuron;novel;novel therapeutics;Outcome;Pathway interactions;Perception;Perinatal;Phase;post stroke;prevent;Process;Public Health;Recovery;Recovery of Function;repaired;Reporting;Reproducibility;Research;response;Rodent;Role;Signal Transduction;stem cell therapy;Stroke;stroke recovery;stroke survivor;stroke therapy;Survival Rate;Survivors;Testing;Therapeutic;Time;tissue regeneration;Transgenic Mice;Viral

PROJECT_TITLE: Mechanisms of Juvenile Neurogenesis and Post-Stroke Recovery: Determining the Role of Age-Associated Neuroimmune Interactions

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Neurosciences;Opioids;Pain Research;Patient Safety

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: NARRATIVE Chronic abdominal pain is the hallmark symptom of chronic pancreatitis (CP), with opioids remaining a mainstay of therapy. Lacosamide, an FDA-approved anticonvulsant, may inhibit the phenomenon known as opioid-induced hyperalgesia, potentially lowering the opioid dose necessary for adequate pain relief. In this proposal, we will evaluate the safety, tolerability and dose-limiting toxicity of combination lacosamide and opioid therapy in CP patients as well as the feasibility of performance of this phase 1 study.

PI_NAMEs: FOGEL, EVAN L (contact);WHITE, FLETCHER A

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Abdominal Pain;Adjuvant;Adverse effects;allodynia;Amino Acids;anti-depressive agents;Anticonvulsants;Carbamazepine;Cardiovascular Physiology;chronic abdominal pain;chronic pancreatitis;Clinical;clinical center;Clinical Trials;Data;design;Disease;Dose;Dose Limiting;drug action;efficacy evaluation;experience;FDA approved;gastrointestinal function;Hyperalgesia;improved;Knowledge;Maximum Tolerated Dose;medical attention;Methods;Mission;Moods;National Institute of Diabetes and Digestive and Kidney Diseases;Neurons;Nociception;novel therapeutic intervention;Opioid;Opioid Analgesics;Opioid Receptor;opioid therapy;opioid use;Outcome;oxcarbazepine;Pain;Pain management;pain reduction;pain relief;pain score;painful neuropathy;Patient Care;Patient Recruitments;Patients;Performance;persistent symptom;Pharmaceutical Preparations;Pharmacologic Actions;Phase;phase 1 study;phase I trial;phase II trial;Pilot Projects;preclinical trial;Quality of life;Refractory;Respiratory physiology;response;Safety;Sample Size;side effect;Sodium Channel;Stimulus;Therapeutic;TLR4 gene;Toxic effect;voltage

PROJECT_TITLE: Safety, tolerability, and dose limiting toxicity of lacosamide in patients with painful chronic pancreatitis

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;HIV/AIDS;Infectious Diseases;Maternal Health;Microbiome;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE HIV-infected women have a greater prevalence of low birth weight infants than HIV-uninfected women. We expect that a greater understanding of the mechanism of low birth weight among WLHIV on ART will lead to improved birth outcomes.

PI_NAMEs: KWIEK, JESSE J;YOTEBIENG, MARCEL  (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: adverse birth outcomes;Age Months;Antibodies;antiretroviral therapy;Atopobium vaginae;Attention;Biological;Birth;Birth Weight;Blood;Cardiovascular Diseases;Caring;Child;Circulation;Clinical;Clinical Data;cohort;Data;Democratic Republic of the Congo;Development;Diarrhea;Dryness;dysbiosis;Ecosystem;Enrollment;Exposure to;Feces;Female of child bearing age;fetal;Fetal Development;Fetal Growth Retardation;Fetus;follow-up;Functional disorder;Genetic Diseases;Growth;Health;HIV;HIV Seronegativity;HIV-exposed uninfected infant;Human Microbiome;Hypertension;immune activation;improved;in silico;in utero;Infant;infant gut microbiome;Infant Health;Infant Mortality;Inflammation;inflammatory marker;Infrastructure;insight;Intervention;Intervention Studies;Laboratories;Link;Low Birth Weight Infant;Low Prevalence;Machine Learning;Maternal Health;Measures;Mediation;Metagenomics;metatranscriptomics;microbial;microbial community;microbial products;microbiome;Modality;Modeling;Morbidity - disease rate;mortality;mortality risk;Mother-to-child HIV transmission;Necrosis;neonate;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;Organism;Outcome;Oxygen;Pathway interactions;Persons;Placenta;Plasma;Postpartum Period;Pregnancy;Pregnancy Outcome;Pregnant Women;Premature Birth;prenatal exposure;prevent;Production;recruit;Risk;scale up;Source;Specimen;Spottings;Swab;Testing;therapy development;Third Pregnancy Trimester;Tissues;transmission process;Umbilical Cord Blood;Vaginal delivery procedure;vaginal infection;vaginal microbiome;vaginal microbiota;Vascular Diseases;virome;Woman;Women's cohort;women's outcomes

PROJECT_TITLE: HIV/ART, low birth weight, and mortality in HIV-exposed uninfected children: a translational mechanistic study

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative The proposed research aims to establish a novel therapeutic target for breast-cancer metastasis by dual targeting cancer cells and immune cells. We propose to use Proteolysis targeting chimera (PROTAC) technology to target pro-survival BCL-XL protein, which leads to the apoptosis of metastatic cancer cells and Tregs. Using in vivo models and fresh cancer specimens, we will determine the mechanisms of targeting BCL-XL in metastatic control and immune regulations.

PI_NAMEs: ZHANG, WEIZHOU  (contact);ZHENG, GUANGRONG ;ZHOU, DAOHONG

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Abscopal effect;Anoikis;anti-cancer;Antigens;Apoptosis;Apoptotic;Autoimmunity;BCL-2 Protein;bcl-xlong protein;BCL2L1 gene;Bioinformatics;Blood Platelets;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;cancer cell;Cancer Model;cancer therapy;carcinogenesis;CD27 Antigens;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Death;cell killing;Cell Survival;cell type;Cells;Cessation of life;chemotherapy;circulating cancer cell;Circulation;Clinic;Clinical;Colon Carcinoma;Cross Presentation;cytotoxicity;Data;Death Rate;Dendritic Cells;Development;Diagnosis;Disseminated Malignant Neoplasm;Distal;Dose Limiting;Equilibrium;Estrogen receptor positive;Exhibits;experience;Genetic;Goals;Harvest;hormone therapy;Human;Immune;Immune system;Immunocompetent;Immunodeficient Mouse;Immunohistochemistry;immunoregulation;Immunotherapy;improved;In Vitro;in vivo;in vivo Model;Infiltration;inhibitor;Knock-out;Lead;Malignant Breast Neoplasm;Malignant Neoplasms;MCL1 gene;Mediating;Metastatic breast cancer;Metastatic/Recurrent;Modeling;Molecular Target;multidisciplinary;Mus;neoantigens;Neoplasm Circulating Cells;Neoplasm Metastasis;new therapeutic target;novel;Organ;Outcome;Pathway interactions;Patients;pharmacologic;Play;prevent;Primary Neoplasm;Protac;protein expression;Regulatory T-Lymphocyte;Renal Cell Carcinoma;Reporting;Research;Role;side effect;Signal Transduction;Specimen;Systemic Therapy;T-Cell Activation;T-Cell Depletion;T-Lymphocyte;targeted treatment;Techniques;Technology;Testing;Therapeutic;therapeutic target;Time;Toxic effect;Translating;Translational Research;treatment strategy;tumor;Tumor Antigens;Tumor Cell Invasion;tumor growth;Tumor Immunity;Tumor Suppression;tumor-immune system interactions;Tumor-infiltrating immune cells;ubiquitin-protein ligase;Ubiquitination;Woman;Work

PROJECT_TITLE: Proteolysis-targeting chimera against BCL-XL inhibits breast cancer metastasis

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_DEPT: CHEMISTRY

ORG_NAME: CITY COLLEGE OF NEW YORK

PHR: Project Narrative A group of 22 faculty researchers at The City College of New York (CCNY) proposes to leverage a position of research strength in the biomedical sciences, within a large public university in the heart of an underserved community, to address the need for a well-trained biomedical research workforce and the gains to be achieved by improving its diversity. Using a strategic combination of NIH and institutional resources, the G-RISE program at CCNY has the demonstrated capacity to support an average cohort of 13 underrepresented (UR) Ph.D. trainees each year for five years, appointing each trainee for 2-3 years. A coordinated program of stimulating interdisciplinary coursework, rigorous research training, and structured activities to build research identity, ethical values, and career readiness will improve the number and proportion of underrepresented Ph.D.’s who pursue rewarding careers in the biomedical research workforce.

PI_NAMEs: STARK, RUTH E. (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Cities;college;New York

PROJECT_TITLE: G-RISE at The City College of New York

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Aging

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Aging is associated with deterioration / dysfunction in the endothelial glycocalyx, a major vasoprotective constituent hyaluronan synthesis enzyme (HAS2) and reduction in arterial function. The endothelial glycocalyx and HAS2 may be causal by altering arterial functions, such as the control of vascular tone, large artery stiffening, and inflammation as well as endothelial specific functions such, nitric oxide bioavailability as well as maintenance of barrier function. We will utilize endothelial specific loss and gain of function mouse models to elucidate the role of HAS2, the enzyme responsible for the production of high molecular weight (HMW) HA, a vasoprotective constituent of the glycocalyx, in altering arterial function across the lifespan of mice. We will also interrogate the role of the CD44 receptor as well as the efficacy of dietary supplementation with HMW-HA to improve these aspects of arterial and endothelial function in advanced age.

PI_NAMEs: DONATO, ANTHONY JOHN (contact);LESNIEWSKI, LISA A

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Age;age effect;age related;age related changes;Aging;anti aging;Aorta;arterial stiffness;Arteries;Attenuated;Binding;Biological Availability;Blocking Antibodies;Blood Vessels;C57BL/6 Mouse;Cardiovascular Diseases;Cardiovascular system;Cause of Death;CD44 Antigens;CD44 gene;Cell Communication;Cell Physiology;Characteristics;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Consensus;Custom;Data;Deterioration;Development;Diet;Dietary Supplementation;efficacy evaluation;Elasticity;Elderly;Endothelial Cells;endothelial dysfunction;Endothelium;Enzymes;Event;Female;Functional disorder;gain of function;Gel;Gene Expression;genetic association;Glycocalyx;Glycosaminoglycans;Human;Hyaluronan;hyaluronan synthase 1;Immune;Impairment;improved;Inflammation;knock-down;Knock-out;life span;Ligands;loss of function;Maintenance;male;Measures;Mediating;middle age;Modeling;Molecular Weight;mouse model;Mus;Nitric Oxide;novel;novel therapeutics;Outcome;Outcome Assessment;Outcome Measure;overexpression;Permeability;Phenotype;Play;Production;Property;Protein Isoforms;receptor;Reporting;Role;Signal Transduction;Structure;Supplementation;Surface;Tamoxifen;Therapeutic Uses;Thick;Tissues;Vascular Diseases;Vascular Endothelium;Vasodilation;Vasodilator Agents

PROJECT_TITLE: Integrative Mechanisms of Vascular Aging

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Estrogen;Infectious Diseases;Women's Health Research

ORG_DEPT: DENTISTRY

PHR: NARRATIVE This project will define the role of inflammasome activation in periodontal disease, that is differentially activated between females and males. The long-term goal of this project is to identify the mechanism(s) of inflammasome modulation to control periodontal bone destruction in both females and males. Knowledge on which biological processes prevent periodontal tissues destruction will allow health providers to identify a therapy that matches individual needs rather than a one-size-fits-all approach. 1

PI_NAMEs: MARCHESAN, JULIE TERESA (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Adjuvant Therapy;Adult;Alveolar Bone Loss;American;Biological;Biological Process;biological sex;bone;Bone Diseases;bone loss;bone repair;Caring;CASP1 gene;Cell Death;Cell membrane;cell type;Chronic Disease;cohort;comparative efficacy;cytokine;Data;Data Analyses;Development;Disease;Excision;Female;Fostering;Gene Deletion;Genetic;Gingiva;Gingivitis;Goals;healing;Health;Health Personnel;High Prevalence;Homeostasis;human tissue;IL18 gene;immune cell infiltrate;Immune response;Individual;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;innate immune function;Innate Immune System;Interleukin-1;Interleukin-1 beta;Interleukins;Knowledge;Ligature;male;men;microbial;Modeling;mortality;Mucous Membrane;Mus;novel;Orchiectomy;Ovariectomy;Pathway interactions;Patients;Pattern recognition receptor;Peptide Hydrolases;Periodontal Diseases;Periodontitis;Periodontium;Population;Prevalence;prevent;Prevention;Process;Production;protein complex;Quality of life;Regulation;repaired;Resolution;response;Role;sensor;Severities;Severity of illness;sex;Sex Differences;sexual dimorphism;Signal Transduction;standard of care;Testing;Therapeutic;therapeutic target;tissue repair;Tissues;Tooth Loss;Tooth structure;translational applications;treatment response;Woman;women versus men

PROJECT_TITLE: Inflammasome regulation underlying sexual dimorphism in periodontitis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Sepsis;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: LEXINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: NARRATIVE Sepsis is a predominant secondary complication that affects quality of life and reduces life expectancy in spinal cord injury (SCI) populations. Although sepsis after SCI is an existing clinical condition, this medical issue unfortunately is understudied due to lack of good animal models. Accordingly, the current innovative proposal is designed to develop, for the first time, a novel rat model of sepsis survivors following SCI to study compromised functional recovery as well as damage to various tissue/organ system(s) due to the compounding effects of SCI- sepsis.

PI_NAMEs: PATEL, SAMIRKUMAR  (contact);SAITO, HIROSHI

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Abdomen;Acute;Address;Affect;Animal Model;Animals;Antibiotics;Biochemical;Blood;Body System;catheter associated UTI;Cause of Death;Clinical;clinically relevant;Complication;Contusions;cytokine;decubitus ulcer;design;Development;Diagnosis;falls;Functional disorder;functional outcomes;Goals;gray matter;Histologic;Histology;Histopathology;Hospitalization;Impairment;improved;Individual;Indwelling Catheter;Infection;Inflammatory;inflammatory marker;Injections;Injury;innovation;Left;Length of Stay;Lesion;Life;Life Expectancy;Liquid substance;Locomotor Recovery;Medical;microbial;Mitochondria;model development;Modeling;Molecular;mortality;motor recovery;multidisciplinary;Multiple Trauma;Muscle;Muscle Weakness;novel;Outcome Measure;Phase;Physiological;Population;Predisposing Factor;Predisposition;Procedures;Quality of life;Rattus;Recovery;Recovery of Function;Research Personnel;Research Proposals;Resuscitation;Rodent;Rodent Model;Secondary to;Sensory;Sepsis;Severities;skeletal muscle weakness;Spinal;Spinal Cord;Spinal cord injury;Spinal cord injury patients;Spleen;Sports;success;Survival Rate;Survivors;Testing;Therapeutic;Time;Tissues;Trauma;vehicular accident;Violence;white matter;young adult

PROJECT_TITLE: Development of a Novel Animal Model for Spinal Cord Injury with Sepsis

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ED_INST_TYPE: OVERALL MEDICAL

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Copper is an essential trace element utilized by eukaryotic cells as an enzymatic redox cofactor, but at high concentrations the metal is toxic, and complex mechanisms have developed to ensure homeostasis. Prokaryotes have a diminished requirement and increased sensitivity to the metal, and it has been established that macrophages utilize copper toxicity as part of their defense against pathogens while the latter combat the host-defense strategy by upregulating their copper export machinery. Our research seeks a better understanding of how biology leverages the fundamental chemistry of copper to achieve functionality, recognizing that function requires balance between the requirements for selective metalation, the structural determinants of catalysis, and pathogenic virulence induced by robust bacterial export pumps.

PI_NAMEs: BLACKBURN, NINIAN J (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: absorption;Amides;Binding;Binding Sites;Biology;Catalysis;Cells;Chemicals;Chemistry;cofactor;combat;Complex;Copper;Coupled;design;Development;Electron Transport;emission spectroscopy;Ensure;Enzymes;Equilibrium;Escherichia coli;Eukaryotic Cell;Homeostasis;Host Defense;Ions;Label;Ligands;Macrophage;Mammalian Cell;MAP2K1 gene;Metals;Mixed Function Oxygenases;Mononuclear;New Territories;novel;Outcomes Research;Oxidation-Reduction;Oxygen;pathogen;Pathogenicity;Pathway interactions;peptide hormone;peptidylglycine alpha-amidating monooxygenase;Phosphotransferases;Physiological;programs;Prokaryotic Cells;Pump;Reaction;Research;Roentgen Rays;Role;Selenomethionine;Signal Transduction;structural determinants;Structure;Toxic effect;Trace Elements;Virulence

PROJECT_TITLE: Mechanisms of Copper Transport and Catalysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Precision Medicine;Rehabilitation;Rural Health;Social Determinants of Health;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: Thrombectomy is a life-saving procedure that removes clot from the brain during stroke, but it is difficult to predict which patients will recover cognitively and which will have persistent cognitive impairment or decline (VCID: vascular contributions to cognitive impairment and dementia)—and it is particularly difficult to predict these outcomes in rural, underserved patients, who tend to have more complicated medical histories and barriers to care. Using a retention strategy tailored to the needs of rural, underserved participants, the proposed study will test how well certain proteins in blood collected at the time of thrombectomy predict the long-term cognitive outcomes of stroke patients in one of the most rural and medically underserved regions in the U.S. Stroke Belt. Study success would address a major rural-urban health disparity and also benefit stroke patients at large by making available the first long-term cognitive profiles of thrombectomy patients, by improving the assignment to proper care using the earliest possible blood markers for VCID versus cognitive recovery, and by opening the door to development of new therapeutics based on blood protein signaling pathways that affect cognitive outcomes.

PI_NAMEs: HARP, JORDAN PATRICK (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Acute;acute stroke;Address;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;barrier to care;Biological;Biological Markers;Blood;Blood Proteins;Blood specimen;Brain;care delivery;Caregiver Burden;Caring;Catchment Area;Characteristics;Chronic;Clinical;Coagulation Process;Cognition;Cognitive;cognitive impairment no dementia;cognitive performance;cognitive recovery;comorbidity;County;Data;Death Rate;Dementia;Development;disability burden;Early Diagnosis;Educational workshop;Enrollment;Equation;Excision;follow-up;functional improvement;Goals;health care availability;health disparity;Health Services Accessibility;Home;Home visitation;Impaired cognition;improved;Inflammation;Inflammatory;Joints;Life;Long term disability;Machine Learning;Measures;Mechanics;medical complication;Medical History;Medical Records;medically underserved;Methods;Modeling;National Heart, Lung, and Blood Institute;National Institute of Neurological Disorders and Stroke;neurocognitive test;novel;novel marker;novel therapeutic intervention;novel therapeutics;Outcome;outcome prediction;Participant;patient population;Patients;Plasma;Positioning Attribute;post stroke;post stroke cognitive impairment;precision medicine;predictive marker;predictive modeling;Procedures;programs;prospective;protein biomarkers;protein expression;Proteins;Proteomics;Registries;Rehabilitation therapy;Research;retention rate;Rural;Rural Appalachia;rural counties;Rural Population;rural underserved;rurality;Sampling;Signal Pathway;Site;social health determinants;Statistical Models;Stroke;Stroke Belt;stroke cognitive outcome;stroke patient;Suburban Population;success;Testing;Thrombectomy;Time;Travel;underserved area;Underserved Population;United States National Institutes of Health;urban health disparities;Validation;vascular cognitive impairment and dementia;Venous blood sampling;Work

PROJECT_TITLE: Predictors and Biomarkers for VCID versus Cognitive Recovery after Stroke Thrombectomy in Rural Appalachia

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: New onset postoperative atrial fibrillation (POAF) is the most common complication after cardiac surgery and substantially affects patient outcomes from the surgery. Our study aims to identify/test the stress-response kinase JNK as a novel POAF biomarker and/or potential anti-POAF therapeutic target. The results from this proposal will form a strong foundation toward achieving our long-term goal of developing novel therapies to treat and prevent AF.

PI_NAMEs: AI, XUN  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Abnormal Cell;Affect;Age;aged;Aging;Alcohol consumption;alcohol exposure;Alcohols;Animal Model;Arrhythmia;Atrial Fibrillation;Biochemical;Biochemistry;biological adaptation to stress;Biological Assay;Biological Markers;Blood;Blood specimen;Cardiac;Cardiac Surgery procedures;Cardiovascular Diseases;Cell Communication;Cellular Stress;Clinic;Clinical;clinical biomarkers;Clinical Research;clinically significant;Collaborations;Complication;Coronary Artery Bypass;cost;Coupling;cytokine;Data;Development;Disease;Dominant-Negative Mutation;Elderly;Electrophysiology (science);Elements;Event;Excision;Exhibits;exosome;Experimental Designs;Foundations;Functional disorder;Funding;Future;gap junction channel;Gene Modified;Gene Transfer;Genes;Goals;Health Care Costs;Heart;Heart Atrium;heart cell;Heart failure;Heart Research;high risk;Hospitals;Human;human model;Image;Impairment;in vivo;Incidence;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;Interleukin-1 beta;Internet;Intervention;Ischemia;Knowledge;Link;MAPK8 gene;MAPK9 gene;Measures;Medical center;Morbidity - disease rate;mortality;mortality risk;mouse model;Mus;Muscle Cells;N-terminal;novel;novel therapeutics;Obesity;Operative Surgical Procedures;Oryctolagus cuniculus;Outcome;overexpression;Paint;particle;Pathogenesis;patient biomarkers;Patient-Focused Outcomes;Patients;Phosphotransferases;Pilot Projects;Plasma;Population;Postoperative Period;Predisposing Factor;Predisposition;prevent;Prevention;Procedures;Property;prospective;Protein Isoforms;Proteins;Pump;Recording of previous events;Reporting;response;Retrospective cohort study;Risk;Risk Factors;RyR2;Series;sex;Stimulus;Stress;Stress Tests;Stroke;Surgeon;surgery outcome;Techniques;Testing;Therapeutic;therapeutic target;Thoracic Surgical Procedures;Time;Tissue Sample;Tissues;TNF gene;translational potential;Work

PROJECT_TITLE: Atrial and blood JNK in Postoperative AF

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Chronic myelomonocytic leukemia (CMML) is a devastating disease that primarily affects the elderly. Oncogenic NRAS mutations are frequently identified in CMML patients. In the prior funded period, we investigated how the genetic interaction between oncogenic Nras signaling and Asxl1 loss promotes CMML progression and transformation to AML. In this renewal application, we propose to investigate the mechanisms underlying dysregulation of immune microenvironment and evaluate mechanism-based immunotherapeutic approaches in our preclinical animal model. Successful completion of the proposed studies will not only provide fundamental perspectives on disease mechanisms but also test hypotheses that could potentially lead directly to potent and efficacious novel therapies for treating CMML and transformed AML.

PI_NAMEs: ZHANG, JING  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acceleration;Acute Myelocytic Leukemia;Affect;Animal Model;antileukemic activity;Binding;Biological Assay;Bromodomain;CD8-Positive T-Lymphocytes;CD80 gene;CD86 gene;cell growth;Cell Physiology;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chronic Myelomonocytic Leukemia;Cleavage Under Targets and Release Using Nuclease;Collaborations;Coupled;cytotoxicity;Diagnosis;Disease;Down-Regulation;effective therapy;Elderly;Enhancers;epigenomics;exhaust;Exhibits;Flow Cytometry;Funding;Genetic;Genetic Transcription;Hematopoietic stem cells;Histones;Human;human data;Immune;immune checkpoint;immune modulating agents;Immunotherapeutic agent;improved;In Vitro;in vivo;inhibitor;International;Lead;lenalidomide;leukemia;Leukemic Cell;leukemic transformation;Ligands;Link;Malignant Neoplasms;Mediating;MEK inhibition;MEKs;Membrane Proteins;Molecular;mouse model;Mus;Mutation;novel;novel therapeutics;Oncogenic;Outcome;overexpression;Pathway interactions;Patients;Phenotype;Population;pre-clinical;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;Protein Analysis;receptor;Resolution;RNA;Sampling;Secondary acute myeloid leukemia;Signal Transduction;small hairpin RNA;Sorting;T-Lymphocyte;Technology;Tertiary Protein Structure;Testing;Therapeutic;Therapeutic Effect;Transcription Factor AP-1;Transcriptional Activation;transcriptome sequencing;transcriptomics;Transplantation;tumor-immune system interactions;Up-Regulation

PROJECT_TITLE: Molecular and Cellular Mechanisms of Chronic Myelomonocytic Leukemia (CMML)

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE While current research is underway to identify potential pharmaceutical treatments for preventing excessive alcohol intake associated with dependence, far less attention is given to potential treatments to curb excessive binge drinking, despite numerous negative health consequences associated with this dangerous behavior. Research has established that sensitivity to the aversive effects of alcohol is protective against overconsumption, yet little is known about the neurocircuitry that modulates aversive responses to alcohol. Expected results will provide novel evidence that norepinephrine circuits originating in the brainstem modulate aversive reactions to alcohol and alcohol consumption, offering new insight into treatments that will protect against the transition to alcohol dependence.

PI_NAMEs: THIELE, MONTSERRAT NAVARRO;THIELE, TODD ERIC (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Adrenergic Receptor;adverse outcome;Agonist;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol response;alcohol use disorder;Alcohols;antagonist;Attention;Attenuated;Behavior;binge drinking;Brain;Brain region;Brain Stem;Cell Nucleus;Confocal Microscopy;Consumption;Dangerous Behavior;Data;Dependence;Dopamine;Dose;drinking;Ethanol;Ethanol dependence;experience;experimental study;Female;Funding;Genetic;Glutamates;Goals;Grant;Health;Heart Diseases;Heavy Drinking;Hypertension;Immunohistochemistry;Individual;innovation;insight;Intake;Investigation;Knowledge;Lateral;Lead;life span;Link;locus ceruleus structure;male;Mood Disorders;motivated behavior;Mus;neural circuit;Neurobiology;Neuronal Plasticity;Neurons;Non-Insulin-Dependent Diabetes Mellitus;Norepinephrine;novel;Nucleus solitarius;Outcome;parabrachial nucleus;Pathway interactions;Pattern;pharmacologic;Pharmacologic Substance;Play;Population;prevent;Property;protein expression;Reaction;receptor expression;Recording of previous events;Reporter;Research;Rewards;Risk;Risk Reduction;Role;Sex Differences;Signal Transduction;Source;Structure;Taste aversion;Testing;Transgenic Mice;Ventral Tegmental Area

PROJECT_TITLE: The role of brainstem norepinephrine in binge alcohol drinking and taste aversion

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebral Palsy;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rehabilitation

ORG_CITY: WILMINGTON

ORG_NAME: NEMOURS CHILDREN'S HOSPITAL, DELAWARE

ORG_STATE: DE

PHR: This proposal addresses pulmonary dysfunction in severe cerebral palsy by using a novel non-invasive respiratory sensor. The two aims of the project are to 1) provide a screening tool to detect respiratory distress and 2) Find a correlation between the degree of pulmonary dysfunction and scoliosis in children with cerebral palsy.

PI_NAMEs: RAHMAN, TARIQ  (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Abdomen;Accident and Emergency department;Address;Adult;awake;Biomedical Engineering;Breathing;Cerebral Palsy;Chest;Child;Childhood;Classification;Clinic;Clinical Research;cohort;Coughing;Data;Diagnosis;Diagnostic;disability;Effectiveness;Ensure;experience;Failure;Flowmeters;Functional disorder;Gait;Goals;Image;Incidence;indexing;innovation;Institution;Intensive Care;Laboratories;Link;Live Birth;Lung;Lung Diseases;Managed Care;Measurement;Measures;Mechanics;Methodology;Motor;Mucous body substance;neuromuscular;novel;Operating Rooms;Outcome;Patients;Persons;Phase;Plethysmography;Pneumonia;pulmonary function;Qualifying;Research;Research Personnel;respiratory;Respiratory Diaphragm;Respiratory distress;Respiratory Insufficiency;Respiratory Muscles;Respiratory physiology;rib bone structure;Risk;Scientist;scoliosis;screening;Screening procedure;sensor;Severities;Sleep;Spirometry;standard measure;Stress;Symptoms;System;Techniques;Technology;Testing;Time;Visual;Walking;Wheelchairs;wireless transmission;Work of Breathing

PROJECT_TITLE: Non-Invasive Measurement of Pulmonary Dysfunction in Children with Cerebral Palsy

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative The proposed research aims to translate innovative magnetic resonance imaging (MRI) techniques to image brain oxygen extraction fraction in patients with vascular contributions in dementia, and understand its mechanistic relationship to ischemic injury in white matter hyperintensities. The technology developed and biological knowledge gained from the project will guide new imaging paradigms to measure brain pathophysiology that leads to cognitive impairment, and improve early vascular interventions in many neurodegenerative disorders.

PI_NAMEs: FAN, AUDREY PEIWEN (contact)

PROJECT_TERMS: Address;Adopted;Affect;Age;Alzheimer's Disease;Anterior;Biological;Biological Markers;biophysical model;Blood - brain barrier anatomy;Blood flow;blood oxygen level dependent;Blood specimen;Blood Vessels;Brain;Brain Diseases;Brain imaging;Brain Ischemia;Brain Mapping;Brain region;brain tissue;cerebrovascular;Cerebrovascular Disorders;cerebrovascular health;Cerebrum;Clinical;Cognition;Cognitive;Compensation;Complex;Contrast Media;Cyclotrons;Dementia;Early Diagnosis;endothelial dysfunction;Endothelium;Episodic memory;Etiology;Evolution;executive function;Exhibits;Functional disorder;Functional Magnetic Resonance Imaging;Future;gray matter;Heterogeneity;Hypoxia;Image;Imaging Techniques;Imaging technology;Impaired cognition;Impairment;improved;Individual;Infarction;Inferior;Injury;innovation;Intervention;Intervention Studies;Ischemia;ischemic injury;Knowledge;Lesion;Link;Location;Longitudinal Studies;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Measures;medial temporal lobe;Memory;Metabolic;Metabolism;Methods;microvascular pathology;MRI Scans;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;Neuronal Injury;neurovascular coupling;new therapeutic target;Noise;novel;older patient;Older Population;Oxygen;Parietal;Parietal Lobe;Pathologic;Pathology;Patients;Performance;Perfusion;Physiological;Play;Positron-Emission Tomography;prevent;Process;radiotracer;Research;Rest;Risk;Role;Scanning;Signal Transduction;Site;Specificity;Stenosis;success;support network;synergism;tau Proteins;Techniques;Technology;Testing;thalamocortical tract;Time;tissue oxygenation;Tissues;tool;Translating;vascular abnormality;vascular cognitive impairment and dementia;vascular contributions;Vascular Dementia;Vascular Diseases;vascular injury;white matter;White Matter Hyperintensity;white matter injury

PROJECT_TITLE: Imaging of brain oxygen extraction fraction in vascular contributions to dementia

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: Chicago

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The project will provide important insight on imaging biomarkers for Parkinson's disease by developing new statistical and computational tools for the continuous time random walk model with newly available high spatial resolution MRI data. The goal is to produce reliable and sensitive imaging biomarkers for Parkinson's disease to improve the diagnosis accuracy, which offers prospects for disease diagnosis and treatment. The proposed research is relevant to the part of NIH's mission that pertains to developing fundamental knowledge in understanding the function of living systems that will help to reduce the burden of human disability and to protect and improve health.

PI_NAMEs: ZHONG, PING-SHOU  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Age;Biological;biomarker identification;brain magnetic resonance imaging;brain tissue;Calculi;Characteristics;Clinical;clinical diagnosis;Clinical Trials;Collaborations;Complex;computerized tools;Data;Data Set;design;Diagnosis;diagnostic accuracy;Diffusion;Diffusion Magnetic Resonance Imaging;Dimensions;disability;Disease;disease diagnosis;Early Diagnosis;Evaluation;Exhibits;expectation;flexibility;Functional Imaging;Goals;Health;Heterogeneity;high dimensionality;Human;illness length;imaging biomarker;improved;innovation;insight;Intervention;Joints;Knowledge;Left;Magnetic Resonance Imaging;Methods;Mission;model building;Modeling;Molecular;Monitor;Movement;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurologic;neuropathology;Normal Statistical Distribution;novel;Organism;Parkinson Disease;Patients;Physiologic pulse;Procedures;radio frequency;Relaxation;Research;Research Personnel;Resolution;Series;sex;Side;simulation;Software Tools;Statistical Methods;Statistical Models;structural imaging;Structure;Substantia nigra structure;Techniques;Testing;Time;Tissues;tool development;two-dimensional;United States National Institutes of Health;user friendly software;Wait Time;Walking;Water;water diffusion

PROJECT_TITLE: Statistical Methods for Biomarkers Identification Using High-resolution Diffusion MRI

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]