NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Narrative Clonal selection and inherent cancer cell plasticity—as well as the ability of cancer cells to undergo adaptation and reprogramming to drug resistant states, following treatment are currently challenging the concept of individual proteins as effective therapeutic targets for an entire tumor mass—especially if identified from bulk tissue analyses. To address these challenges, we have identified a more universal class of mutation- agnostic, non-oncogene dependencies implemented by Tumor Checkpoint (TC) modules, comprising small sets of Master Regulator (MR) proteins working in concert to implement and maintain tumor cell state by canalizing the effect of mutations and signals in their upstream pathways. Our proposal will thus focus on the elucidation and pharmacological targeting of MRs and TC-modules at the single cell level, within molecularly distinct, yet co-existing tumor subpopulations, leading to design of successful combination therapy approaches and discovery of mechanisms of drug resistance and cell adaptation.

PI_NAMEs: CALIFANO, ANDREA  (contact)

PROGRAM_OFFICER_NAME: MCCARTHY, CLAIRE ELLEN

PROJECT_TERMS: Acute;Address;Adult;Biological Assay;Biological Markers;biomarker development;Breast Adenocarcinoma;cancer cell;cancer genetics;Cancer Patient;Categories;Cells;CLIA certified;Clinical;Clinical Trials;cohort;Collaborations;Combined Modality Therapy;Data Set;Dependence;design;Desmoplastic Small Round Cell Tumor;Development;Dissection;Drug Controls;Drug resistance;drug sensitivity;Drug Targeting;falls;follow-up;Genetic;Genetic Transcription;Glioblastoma;Goals;Health;Immunotherapy;improved;Individual;Maintenance;Malignant Childhood Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Methodology;Molecular;Mutate;Mutation;neoplastic cell;Network-based;Neuroblastoma;Neuroendocrine Tumors;novel;Oncogenes;Oncoproteins;Pathway interactions;patient derived xenograft model;Patients;Pediatric Neoplasm;Pharmaceutical Preparations;pharmacologic;Population;Progression-Free Survivals;Prostate;Prostate Adenocarcinoma;Proteins;Relapse;Reporter Genes;Research Personnel;resistance mechanism;response;Reverse engineering;Role;Sarcoma;Signal Transduction;single-cell RNA sequencing;Slice;success;targeted treatment;Testing;The Cancer Genome Atlas;therapeutic target;therapeutically effective;Tissues;transcription factor;tumor;Tumor Subtype;tumorigenesis;Validation

PROJECT_TITLE: Elucidating and Targeting tumor dependencies and drug resistance determinants at the single cell level


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: HAMPTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: HAMPTON UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative and relevance to human health and disease Current clinical tool in prostate cancer — serum Prostate Specific Antigen (PSA) — can only suggest abnormalities in prostatic glands but cannot clearly ascertain cancer. Exosomes are tiny vesicles shed by cells into body fluids that can be used to evaluate disease condition, including cancer. By determining if analysis of these exosomes can let physicians monitor response to proton therapy, we will further the goal of providing tailored proton therapy treatment to prostate cancer patients.

PI_NAMEs: HEYLIGER, SIMONE OLIVIA (contact)

PROJECT_TERMS: Achievement;African American population;anti-cancer research;Area;Biological Markers;Biopsy;Blood;Blood specimen;Body Fluids;cancer genomics;Cancer Patient;Cells;Cerebrospinal Fluid;Cessation of life;Clinical;clinical decision-making;cohort;Collaborations;Data;Decision Making;Detection;detection method;Development;Disease;DNA;European;Evaluation;Excision;exosome;extracellular vesicles;Feasibility Studies;follow-up;Future;Genes;Genetic;Genomics;Goals;Grant;Health;Historically Black Colleges and Universities;Human;improved;Joints;Legal patent;Lipids;liquid biopsy;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Measures;medical schools;men;Messenger RNA;microvesicles;Modality;Molecular;Monitor;Neoplasm Metastasis;neoplastic cell;Newly Diagnosed;non-invasive monitor;Normal Cell;novel;Operative Surgical Procedures;Outcome;Outcomes Research;particle;Patients;Physicians;Preparation;Process;prognostic;Prostate;prostate biopsy;Prostate-Specific Antigen;Prostatectomy;Prostatic;Proteins;proton therapy;Radiation Monitoring;Radiation therapy;Radical Prostatectomy;recruit;Recurrence;Research;Research Infrastructure;response;response biomarker;Rest;Risk;Risk Assessment;RNA;Saliva;Sampling;serum PSA;Site;specific biomarkers;Testing;Time Study;Tissues;tool;Toxic effect;trafficking;treatment response;tumor;tumor microenvironment;Universities;unnecessary treatment;Urine;Urologic Oncology;Urology;Vesicle;Virginia;Work

PROJECT_TITLE: Exosomal RNA: A Novel Signature Guide for Prostate Cancer Proton Therapy


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE Medulloblastoma (MB) is a highly aggressive childhood brain tumor for which safer and more effective therapies are urgently needed. By surveying genetic predisposition to MB in >1,000 patients, we recently discovered pathogenic ELP1 germline variants in 14% of pediatric SHH-MB patients, implicating ELP1 as the most prevalent MB predisposition gene. This proposal will determine the phenotypic, biochemical, and molecular consequences of ELP1 loss-of-function during development and tumorigenesis, with the objective of improving treatments and outcomes for affected children and their families in the future.

PI_NAMEs: NORTHCOTT, PAUL  (contact)

PROJECT_TERMS: Affect;Age;aggressive therapy;Anticodon;Biochemical;Biogenesis;Biological;biological heterogeneity;Blood Vessels;Brain;cancer predisposition;cancer risk;Cells;Cellular Morphology;Cerebellum;Chemicals;Child;Childhood;Childhood Brain Neoplasm;Childhood Malignant Brain Tumor;Clinical;Code;Codon Nucleotides;Complex;Consensus;CRISPR/Cas technology;Cytoplasmic Granules;Defect;demographics;Development;Disease;effective therapy;Embryo;Exhibits;Family;Functional disorder;Future;Gene Modified;Genes;Genetic;Genetic Predisposition to Disease;Genetically Engineered Mouse;Genomics;Germ Lines;Germ-Line Mutation;Histopathology;human disease;Image;Immunofluorescence Immunologic;Immunohistochemistry;Impairment;improved;improved outcome;In Vitro;interest;Knock-out;Link;loss of function;loss of function mutation;Loss of Heterozygosity;Maintenance;Malignant - descriptor;Medulloblastoma;Modeling;Modification;Molecular;multiple omics;Mus;mutant;Mutation;Neoplasms;nerve stem cell;neurodevelopment;novel;Oncogenes;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;patient derived xenograft model;Patients;Phenotype;Physiological;PPM1D gene;Pre-Clinical Model;programs;Proliferating;Protein Complex Subunit;protein folding;Proteins;Proteome;proteostasis;proteostasis loss;Reagent;Research;Research Personnel;response;risk variant;Role;scaffold;Scientist;Secondary to;Series;sex;SHH gene;side effect;Signal Transduction;Subgroup;Surveys;Survivors;Susceptibility Gene;Testing;TP53 gene;Transfer RNA;Transgenic Mice;Transgenic Organisms;Translational Regulation;Translations;Transplantation;treatment and outcome;tumor;Tumor Suppressor Proteins;tumorigenesis;Uridine;Variant

PROJECT_TITLE: Characterization of ELP1 as a novel SHH medulloblastoma predisposition gene


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: PORTLAND

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE: OVERALL COMPONENT This is a core grant (“Ophthalmology Core Facility”) to the Oregon Health and Science University (OHSU) Casey Eye Institute to fund four service cores and support vision researchers studying a wide range of blinding diseases. These entail shared, sophisticated instrumentation and expertise that would be unobtainable by individual researchers. These cores consist of (1) high magnification imaging of proteins in tissue samples and live-imaging technologies for small animal models; (2) methods to detect gene expression within tissues and methods to activate or suppress them to understand how they contribute to eye disease; (3) methods that will help investigators discover gene alterations in patient and model samples and cell cultures, as well as sophisticated statistical expertise to analyze complex gene and population data sets; and (4) methods for detecting protein composition in eye tissues and how they are altered in normal and diseased eyes.

PI_NAMEs: MORRISON, JOHN C (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Academic support;Age;Angiography;animal imaging;Animal Model;bench to bedside;bioimaging;Bioinformatics;Biological;Biometry;Biostatistics Core;Blood specimen;career;Cataract;Cell Culture Techniques;Cells;Cellular biology;Childhood;Clinical;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;Complex;Confocal Microscopy;Core Facility;Core Grant;CRISPR/Cas technology;Data Analyses;Data Set;design;detection method;Development;Diabetic Retinopathy;Disease;DNA;Ensure;Equipment;Eye;Eye diseases;Faculty;Family suidae;Fibroblasts;Funding;Gene Chips;gene discovery;Gene Expression;Gene Mutation;Gene Proteins;Genes;Genetic;genetic manipulation;Genetic Models;Genotype;Glaucoma;Goals;Grant;Health;Human;Human Resources;Image;Imaging technology;in vivo imaging;Individual;Inherited;instrumentation;Macular degeneration;Maintenance;Measures;Mentored Clinical Scientist Development Program;Mentors;Methods;microscopic imaging;Modeling;Modification;Molecular;Molecular Genetics;Mus;nonhuman primate;Ophthalmology;Optical Coherence Tomography;Oregon;Organ Culture Techniques;overexpression;patient population;Patients;Phenotype;Physiology;Population;precision medicine;Primary Cell Cultures;Primates;programs;protein folding;Proteins;Proteomics;Rattus;Research;Research Design;Research Infrastructure;Research Personnel;research study;Resolution;Resource Sharing;Resources;response;Retinal Diseases;retinal imaging;RNA Interference;Rodent;Saliva;Sampling;Science;Scientist;Services;Techniques;tissue culture;Tissue Sample;Tissues;Training;transcriptome sequencing;Universities;Uveitis;Vision;Vision research;Work

PROJECT_TITLE: Ophthalmology Core Facility


ADMINISTERING_IC: EB

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: QUADRIDOX, INC.

ORG_STATE: NC

PHR: RELEVANCE NARRATIVE This project will provide a first-of-its-kind, clinical XRDI scanner for rapid, volumetric imaging of pathology specimens with the ability to inform pathologists about the likelihood and location of cancer within different tumor slices. It will enable analysis of the whole slice volume rather than a few microns at the surface of a subset of the slices. It will enable quantitative identification of disease based on molecular signatures obtained directly from the tissue, thereby eliminating user-related subjectivity, and improving the overall workflow. It would significantly speed up pathology workflow, providing analysis and response within minutes instead of days and considerably improve the productivity and profitability of the pathology lab.

PI_NAMEs: GREENBERG, JOEL  (contact)

PROGRAM_OFFICER_NAME: ASHMONT, KARI RICH

PROJECT_TERMS: absorption;Affect;Algorithmic Software;Area Under Curve;Benchmarking;biobank;Breast;Calibration;cancer site;Carcinoma;Caring;Classification;classification algorithm;Clinical;clinical diagnosis;clinical imaging;Clinical Pathology;clinical translation;cohort;Collaborations;commercialization;cost;Data;Development;Diagnosis;Diagnostic;Disease;Economics;Equilibrium;Evaluation;Face;Faculty;field study;Goals;Histologic;Hospitals;Hour;Image;image reconstruction;imaging software;imaging system;Imaging technology;improved;Individual;Insurance;Laboratories;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Manuals;Marketing;Measurement;Medical;Metadata;Methods;Microscope;Microscopic;Microscopy;Molecular Profiling;new technology;Operative Surgical Procedures;Palpation;Pathologist;Pathology;pathology imaging;Performance;Phase;Play;Preparation;Process;Productivity;prototype;Publishing;Receiver Operating Characteristics;Reproducibility;Research;Resected;Resolution;response;Roentgen Rays;Role;Sampling;satisfaction;Scanning;Series;skills;Slice;Slide;Small Business Innovation Research Grant;software development;Specimen;Speed;standard of care;Surface;System;Technology;Testing;Thick;Time;Tissues;tool;transmission process;tumor;Universities;usability;user friendly software;Work;Workload;X ray diffraction analysis

PROJECT_TITLE: Development and evaluation of a combined X-ray transmission and diffraction imaging system for pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-Z(10)B]


ADMINISTERING_IC: GM

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Narrative CRISPR screens hold great promise for the understanding of protein functions in a high-throughput manner. We propose to develop computational methods to address the bioinformatics needs in the design of CRISPR screens, and to repurpose CRISPR screens for innovative solutions to the understanding of protein structure, interaction, regulation and cellular roles. For method evaluation and proof-of-concept applications, we propose to apply the methods to the studies of transcription factors and epigenetic regulators, which are important protein categories involved in physiology and disease.

PI_NAMEs: XU, HAN  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;Bioinformatics;Biological;biological systems;Biology;Biotechnology;Categories;Clustered Regularly Interspaced Short Palindromic Repeats;Computing Methodologies;CRISPR screen;Data;Data Analyses;design;Development;Disease;Epigenetic Process;epigenetic regulation;Evaluation;experimental study;Goals;improved;innovation;insight;Knock-out;Libraries;Methodology;Methods;novel;Physiology;protein function;protein protein interaction;protein structure;Proteins;Protocols documentation;Regulation;Research;Role;Techniques;Tertiary Protein Structure;transcription factor;transcription regulatory network;Transcriptional Regulation

PROJECT_TITLE: Computational approaches for protein functional analysis using CRISPR screens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Social Determinants of Health

PHR: Project Narrative: Training and Education Program Diverse investigators play an integral role in identifying novel research questions, perspectives, and solutions to complex biomedical challenges. Yet, diversifying the biomedical research workforce remains a major challenge in the US, despite the fact that underrepresented minorities make up the most rapidly growing segment of the US population Thus, in a unique partnership between the Icahn School of Medicine at Mount Sinai and Hampton University, we propose to provide hybrid training and education to increase the research capacity, engagement, and success of the HU scientific workforce, with particular emphasis on genetics and genomics and cancer disparities research.

PI_NAMEs: MCGEE, ZINA  (contact)

PROJECT_TERMS: anti-cancer research;Appointment;Area;biological systems;Biomedical Research;Biometry;cancer genomics;cancer health disparity;Clinical;Clinical Research;Collaborations;community engaged research;Complex;Coupled;Data Science;design;Development;Discipline;doctoral student;early-career faculty;education research;Educational Curriculum;Educational process of instructing;Educational workshop;Epidemiology;equity, diversity, and inclusion;Faculty;faculty community;Feasibility Studies;Fostering;Foundations;Funding;Genetic;genome sciences;Genomics;Goals;Grant;Health Disparities Research;health disparity;Hybrids;Impact evaluation;innovation;insight;Intervention;Learning;lectures;Malignant Neoplasms;medical schools;member;Mentors;Mentorship;Minority;Minority Groups;minority investigator;National Human Genome Research Institute;National Institute of General Medical Sciences;novel;people of color;Persons;Play;Population;Positioning Attribute;Postdoctoral Fellow;Productivity;programs;Race;Research;Research Methodology;Research Personnel;Research Project Grants;Research Support;Research Training;response;Role;Science;Series;Services;Site;skills;statistics;Stream;Students;success;Training;Training and Education;undergraduate student;Underrepresented Minority;Universities;university student;virtual

PROJECT_TITLE: Cancer Research Education Program


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Sleep Research

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Almost one billion people worldwide have obstructive sleep apnea (OSA), a disease associated with significant co-morbid outcomes and diverse clinical manifestations. Current models for predicting OSA outcomes help guide OSA treatment options, but they are based on limited data and do not perform equally well for all people. This project will apply modern machine learning and rich electronic medical records data to better understand how OSA outcomes disparately affect different groups and to predict risks of OSA outcomes consistently for individual patients of all demographic groups.

PI_NAMEs: BORZA, VICTOR  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Accounting;Acute;Address;Affect;Age;Algorithms;Asian population;benefit sharing;Cardiovascular Diseases;career;Characteristics;Chronic;Classification;Clinical;Clinical Data;clinical practice;clinically actionable;comorbidity;Computer Models;Computerized Medical Record;Computing Methodologies;Continuous Positive Airway Pressure;COVID-19;Data;Data Set;Dementia;demographics;Diabetic Nephropathy;Diagnosis;Disease;Disparity;Drowsy Driving;Ethnic Origin;Exhibits;Foundations;Functional disorder;Future;Gender;Geographic Locations;Grant;improved;Individual;individual patient;insight;Intervention;Intuition;Investigation;Machine Learning;machine learning classifier;machine learning prediction;Measurement;Metabolic syndrome;Methods;model building;Modeling;Modernization;neuropsychiatric disorder;Obstructive Sleep Apnea;Operative Surgical Procedures;Outcome;outcome disparities;Outcomes Research;Patient Care;Patient Compliance;patient screening;Patients;Pattern;Performance;Persons;Phenotype;Physicians;Population;predictive modeling;Prevalence;Process;Questionnaires;Race;Recommendation;Research;Research Ethics;Resources;Risk;risk prediction;Severities;skills;Sleep Apnea Syndromes;Socioeconomic Status;Subgroup;Symptoms;Testing;Time;Translating;treatment effect;treatment guidelines;treatment response;treatment strategy;Vehicle crash;Woman

PROJECT_TITLE: Fair risk profiles and predictive models for outcomes of obstructive sleep apnea through electronic medical record data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebral Palsy;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Services;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Rehabilitation;Telehealth

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Cerebral palsy (CP) is the most common pediatric movement disorder in the US and in the world, yet many infants still lack access to effective early interventions due to resource or geographic challenges. The current proposal uses rigorous methods to test the telehealth delivery of a proven parent-administered, medical-team directed rehabilitative strategy for CP. By comparing this approach to standard care and to one of parent support and education, the study determines if a tele-heath approach is effective, how old infants need to be to benefit from the intervention, and if parents benefit from more evidence-based supports to become more effective in administering intervention to their infants.

PI_NAMEs: MAITRE, NATHALIE  (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: active method;Address;Affect;Age;Area;arm function;Attention;Biological;blind;Brain;Businesses;Cerebral Palsy;Child;Child Rearing;Childhood;cohort;Consensus;Control Groups;coping;cost effectiveness;Cues;Data;design;Development;Developmental Therapeutics Program;Diagnosis;early childhood;Early Diagnosis;Early Intervention;Education;effective therapy;Effectiveness;effectiveness study;Emotional;Ensure;evidence base;expectation;experience;Feedback;Frequencies;functional outcomes;Funding;Geography;Goals;Guidelines;Hand;Hand functions;hand rehabilitation;Health Services Accessibility;Healthcare Systems;Home;improved;Infant;Institution;Intervention;Knowledge;knowledgebase;Link;Manipulative Therapies;Manuals;Measurement;Measures;Medical;Methods;Modeling;Monitor;Motor;Motor Activity;motor impairment;motor learning;Motor Skills;Movement Disorders;multimodality;Neurosciences;novel;Outcome;parenting intervention;Parents;Patient Outcomes Assessments;Performance;Phase;physically handicapped;primary outcome;psychoeducation;Psychology;Psychometrics;Public Health;Randomized;Randomized, Controlled Trials;Rehabilitation therapy;remote administration;remote health care;Reporting;Reproducibility;Resources;Schedule;secondary endpoint;Sensorimotor functions;Sensory;Severities;sex;Site;socioeconomics;somatosensory;Somatosensory Cortex;sound;standard care;standard of care;Standardization;success;telehealth;Testing;treatment comparison;treatment effect;Upper Extremity;Vision;Waiting Lists

PROJECT_TITLE: APPLES: Early Childhood Constraint Therapy for Sensory/Motor Impairment in Cerebral Palsy

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Neurosciences;Prevention;Stroke;Telehealth

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: ]Atherosclerotic plaque in the carotid arteries is responsible for 10 to 15% of all ischemic strokes. The ongoing NINDS-funded CREST-2 multicenter randomized clinical trial is testing whether in the short term (up to 4 years after study entry) procedural revascularization prevents stroke beyond what can be achieved with intensive medical management of vascular risk factors, especially hypertension and hyperlipidemia. We propose a cost-efficient, centralized process of telephone visits, telehealth visits, and medical records review to monitor patients for stroke endpoints and group-level control of risk factors after the 4-year graduation from CREST-2 to assess rigorously the real-world long-term effectiveness of intensive medical management.

PI_NAMEs: HOWARD, GEORGE ;LAL, BRAJESH K;MESCHIA, JAMES F (contact);VOEKS, JENIFER

PROGRAM_OFFICER_NAME: JANIS, SCOTT

PROJECT_TERMS: Arterial Fatty Streak;atherosclerosis risk;beneficiary;Blinded;Blood Tests;Blood Vessels;Carotid Arteries;Carotid Atherosclerotic Disease;Carotid Endarterectomy;Carotid stent;Cessation of life;Clinic Visits;Clinical;clinical practice;cost effective;cost effectiveness;cost efficient;Data;design;Detection;Devices;Effectiveness;Event;follow-up;Funding;hazard;Health;Home;Hyperlipidemia;Hypertension;improved;Informed Consent;innovation;Intention;Ipsilateral;Ischemic Stroke;Life;Longterm Follow-up;Measurement;Medical;Medical Records;Medicare;medication compliance;Methodology;Modeling;Modernization;Monitor;National Institute of Neurological Disorders and Stroke;Neurologic Deficit;Neurologist;North America;Participant;Patient Monitoring;patient subsets;Patients;Periodicals;Pharmaceutical Preparations;Population;Prevention trial;primary outcome;Procedures;Process;Randomized;randomized, clinical trials;Recruitment Activity;Relative Risks;remote monitoring;Rest;restenosis;revascularization;Risk;Risk Factors;Risk Reduction;Sample Size;Sampling;Secure;Site;standard of care;Stroke;stroke patient;Stroke prevention;stroke risk;study population;telehealth;Telephone;Testing;Therapeutic Intervention;Time;Titrations;treatment effect;Treatment Efficacy;treatment group;trial comparing;trial design;vascular risk factor;video visit;Visit;Writing

PROJECT_TITLE: Long-Term Observational Extension of Participants in the CREST-2 Randomized Clinical Trial


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Esophageal Cancer;Genetics;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stomach Cancer

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: NARRATIVE The molecular features of esophageal adenocarcinoma and intestinal gastric cancer suggest they are a single disease from a common and unusual cell-of-origin. Therapeutics that target this common cell-of-origin could contribute to strategies for the elimination of these lethal cancers.

PI_NAMEs: AJANI, JAFFER A.;MCKEON, FRANK D. (contact);XIAN, WA

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Adult;advanced disease;Agreement;B-Lymphocytes;Barrett Esophagus;Biology;cancer genetics;cancer genomics;Cancer Model;carcinogenesis;Categories;Cell surface;cell type;Cells;Chronic;Clinical;Clone Cells;Cloning;Data;Data Set;Detection;differentiation in vitro;Disease;Distal;Drug Combinations;drug development;drug discovery;Drug Screening;Dysplasia;Early Diagnosis;Embryonic Development;Engineering;Esophageal Adenocarcinoma;Esophageal mucous membrane;Esophagogastric Junction;Esophagus;Evolution;Expression Profiling;Gastric Adenocarcinoma;Gastric and esophageal adenocarcinomas;gastric intestinal metaplasia;Gastric mucosa;gastrointestinal;Gene Expression;Gene Expression Profile;Genes;Genetic;Gland;high-throughput drug screening;Histologic;Homeobox;Human;human fetal cells;human stem cells;In Vitro;in vivo;inhibitor;insight;Intestinal Metaplasia;Intestines;Kinetics;Knockout Mice;Lesion;Link;Malignant neoplasm of esophagus;Malignant Neoplasms;malignant stomach neoplasm;Methods;Modeling;Molecular;Molecular Profiling;mouse model;Mucous Membrane;Mus;Mutation;Natural History;Oncogenes;Oncogenic;Oncologist;Pathology;patient - derived stem cells;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phylogenetic Analysis;Population;premalignant;prevent;Proliferating;prospective;Proteomics;Resolution;Site;small molecule;Sorting;Source;Specialist;spelling;stem cell population;stem cells;Stomach;Technology;Therapeutic;therapeutic target;Tissues;transcription factor;tumor;upper gastrointestinal cancer;whole genome;Xenograft procedure

PROJECT_TITLE: Common Stem Cell of Origin for Junctional and Gastric Adenocarcinoma


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PHR: PROJECT NARRATIVE Medulloblastoma (MB) comprises four distinct subtypes with different cellular and molecular origins, and different clinical outcomes. We will investigate how DDX3X, the second most frequently mutated MB gene affecting three MB subtypes, patterns the hindbrain and suppresses MB. We will identify novel effective therapeutic approaches to minimize debilitating long-term toxicities for patients with the WNT-MB subtype.

PI_NAMEs: GILBERTSON, RICHARD  (contact)

PROJECT_TERMS: Address;Affect;Animal Hospitals;Antibodies;Antibody-drug conjugates;Biochemical;Biological;biological adaptation to stress;Biological Assay;Biological Process;Blood - brain barrier anatomy;blood-brain barrier disruption;Brain;Cell Fate Control;Cell membrane;Cell Surface Proteins;Cells;Cellular Stress;chemotherapy;Chemotherapy and/or radiation;Child;ChIP-seq;Clinical;Clinical Trials;Combined Modality Therapy;Complement;Conventional Surgery;crosslinking and immunoprecipitation sequencing;CTNNB1 gene;curative treatments;Data;Development;Drug Kinetics;Funding;Genes;Genetic;Genetic Transcription;Genomics;Goals;hindbrain;Hospitals;House mice;Immune response;Immunotherapy;In Vitro;in vivo;insight;irradiation;Link;Malignant - descriptor;Maps;Mediating;Medulloblastoma;Molecular;mouse model;Mus;mutant;Mutate;Mutation;Neoplasms;neoplastic cell;nerve stem cell;neurodevelopment;neurosurgery;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Paracrine Communication;paralogous gene;Patients;Pattern;Pharmacodynamics;Phenotype;pre-clinical;Preclinical Testing;Predisposition;Process;Proteome;Radiation therapy;Regulation;Resistance;RNA Helicase;Series;SHH gene;side effect;Signal Transduction;Survivors;targeted treatment;Testing;therapeutically effective;Therapy trial;Toxic effect;transcriptome sequencing;Translating;Translations;treatment response;tumor;Tumor Subtype;Work

PROJECT_TITLE: Regulation of Cell Fate and Treatment Response in WNT Medulloblastoma


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative  The Cancer Pharmacokinetics Research Specialist will support the development of new anticancer agents through supporting preclinical and clinical cancer research, thus serving the scientific community in early drug development needs which will lead to enhancement of patient care and treatment outcome.

PI_NAMEs: PARISE, ROBERT  (contact)

PROGRAM_OFFICER_NAME: IVY, S PERCY

PROJECT_TERMS: anti-cancer research;Award;Cancer Center;care outcomes;career;Categories;Clinical;Communities;Computer software;Development;drug development;Drug Kinetics;Funding;Goals;Human Resources;instrument;Malignant Neoplasms;Metabolism;Methodology;novel;novel anticancer drug;Output;Patient Care;pharmacokinetics and pharmacodynamics;Play;pre-clinical;Research;Role;skills;Specialist;Training;Treatment outcome


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Nanotechnology

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PI_NAMEs: ZACK, DONALD J. (contact)

PROJECT_TERMS: Animal Model;Bioinformatics;Biometry;Budgets;Center Core Grants;Core Grant;Drug Delivery Systems;Equity;Feedback;Funding;Health Services Accessibility;Human Resources;Image;Individual;meetings;Microscopy;Monitor;Nanotechnology;operation;Periodicals;programs;Research;Research Project Grants;Schedule;Surveys;System;Vision research;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Neurosciences;Regenerative Medicine

PI_NAMEs: QUIGLEY, HARRY ALAN (contact)

PROJECT_TERMS: Cell Separation;Collaborations;Communities;Consultations;Core Facility;Core Grant;Electron Microscopy;Equipment;equipment training;experience;Experimental Designs;Eye;Fostering;Funding;high throughput screening;Histologic;Home;Human Resources;Image;Location;Maintenance;Methodology;Microscopy;multi-photon;nanomedicine;Ophthalmology;Productivity;programs;Publications;Regenerative Medicine;Research;Research Personnel;Resources;Scanning Electron Microscopy;Scientist;stem cells;Tissue Engineering;Training;Transmission Electron Microscopy;United States National Institutes of Health;Vision;Vision research

PROJECT_TITLE: Microscopy and Imaging Module


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE This project is relevant to public health because identifying mutations that drive pancreatic cancer could reveal novel targets to treat this deadly and currently therapeutic-resistant disease. We recently identified a group of mutations related to RNA splicing that can be blocked with both existing and emerging therapies that impede tumor growth and extend survival in animal models. In the proposed work we will 1) determine the role of these mutations in driving pancreatic cancer development, 2) identify and correct the RNA splicing defects required for the mutations to exert their effects, and 3) test two types of novel therapies to restore normal RNA splicing and determine anti-tumor efficacy.

PI_NAMEs: ESCOBAR HOYOS, LUISA  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Animal Model;Automobile Driving;Biotechnology;Cancer Patient;Cell Line;Cell Proliferation;Cell Survival;Cells;Cessation of life;chemotherapeutic agent;clinical investigation;Clustered Regularly Interspaced Short Palindromic Repeats;Defect;design;Development;Disease Resistance;driver mutation;drug sensitivity;Event;Frequencies;Future;gain of function;gain of function mutation;Genetic;Genetic Transcription;Genetically Engineered Mouse;Genomics;Genotype;Goals;Histologic;improved;In Vitro;in vivo;inhibitor;innovation;Knowledge;KRAS oncogenesis;KRAS2 gene;Lead;Link;loss of function;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;Messenger RNA;Methods;Mission;Modality;Modeling;Molecular;molecular subtypes;Monitor;mouse model;Mus;mutant;Mutation;new therapeutic target;novel;novel therapeutics;Oligonucleotides;Oncogenic;Oncoproteins;Outcome;Pancreas;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;personalized medicine;Pharmaceutical Preparations;Pharmacogenomics;Phenocopy;Play;Pre-Clinical Model;Precision therapeutics;Predisposition;Protein Isoforms;Public Health;refractory cancer;Research;Resistance;response;RNA Splicing;Role;Sampling;Scientific Advances and Accomplishments;screening;Signal Transduction;small molecule;small molecule inhibitor;Spliceosomes;Study models;synergism;targeted treatment;Testing;Therapeutic;therapeutic target;Therapeutically Targetable;therapy development;therapy outcome;therapy resistant;TP53 gene;transcriptome;transcriptome sequencing;Treatment Efficacy;treatment response;tumor;tumor growth;tumorigenesis;tumorigenic;Tumorigenicity;ultrasound;Work

PROJECT_TITLE: Understanding and targeting mutant splicing factors in pancreatic cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

PI_NAMEs: ABRAHAM, ALISON G (contact)

PROJECT_TERMS: Algorithms;Applications Grants;Area;Assessment tool;Big Data;Biometry;Biostatistics Core;Businesses;Collaborations;Communities;Computer software;Core Grant;cost;cost efficient;Data;Data Analyses;data management;Data Science;Databases;Dedications;Development;Education;education resources;Educational workshop;Ensure;Epidemiologist;Epidemiology;Eye;Faculty;faculty support;Feedback;Fees;flexibility;Fostering;frontier;Funding;Future;Goals;Grant;Growth;Hour;Human Resources;improved;Individual;innovation;Institution;interdisciplinary collaboration;interest;Internet;lectures;Link;Manuscripts;Methodology;Mission;novel;Online Systems;Ophthalmology;Outcome;Outcome Assessment;Output;outreach;Patient Care;Patients;Phase;Preparation;Procedures;Productivity;Progress Reports;Protocols documentation;Public Health Schools;Publications;Research;Research Design;Research Personnel;Research Project Grants;Resources;Sampling;satisfaction;Schools;Scientist;Services;Site;skills;Standardization;statistical service;Structure;success;symposium;System;Technology;Technology Transfer;Time;Training;Training and Education;United States Centers for Medicare and Medicaid Services;Vision;Vision research;web site;web-based assessment;Work

PROJECT_TITLE: Biostatistics Module


NIH_SPENDING_CATS: Cancer;Neurosciences

PHR: Core Narrative The Administrative Core functions as a central resource to maximize interactions through efficient coordination of the individual Projects and Core Laboratories so that the Program as a whole can achieve its goals. The Core facilitates interactions between Program members, monitors progress and core usage, and is responsible for administrative oversight and budget management.

PI_NAMEs: BAKER, SUZANNE J. (contact)

PROJECT_TERMS: Acceleration;Bioinformatics;Biostatistics Core;Brain;Budgets;Collaborations;Communication;conflict resolution;data integration;Data Set;Development;Ensure;Equity;Fostering;Goals;Grant;Individual;Institution;Investigation;Laboratories;meetings;member;Monitor;Neoplasms;Principal Investigator;Productivity;programs;Progress Reports;Reporting;Research;Research Personnel;Resources;Saint Jude Children's Research Hospital;Schedule;Site;Strategic Planning;success;synergism;United States National Institutes of Health;Universities;Videoconferencing;Visit;Work

PROJECT_TITLE: CORE A - Administration


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome

PI_NAMEs: QIAN, JIANG  (contact)

PROJECT_TERMS: analytical tool;Applications Grants;Area;Basic Science;Big Data;Bioinformatics;Cells;ChIP-seq;Communities;Core Grant;Data;Data Analyses;Databases;design;Disease;Doctor of Philosophy;Education;experience;Eye;flexibility;Funding;Genome;Genomics;Grant;Informatics;Laboratories;Letters;medical schools;member;Molecular Biology;next generation;next generation sequencing;Postdoctoral Fellow;Productivity;professor;Progress Reports;Proteomics;Research;research faculty;Research Personnel;Research Project Grants;Research Proposals;Resources;Science;Scientist;Sequence Analysis;Series;Services;single cell sequencing;skills;Structure;Students;success;Techniques;Technology;transcriptome sequencing;United States National Institutes of Health;Universities;Vision research;Work;Writing

PROJECT_TITLE: Bioinformatics Module


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Immunotherapy;Lung;Organ Transplantation;Transplantation

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Antibody-mediated rejection after lung transplantation commonly results in allograft failure and death in spite of current therapeutic regimens. We are testing the safety and tolerability of the addition of a novel immunosuppressive medication to routine treatment for antibody-mediated rejection. Future studies will be needed to assess efficacy if this study demonstrates safety.

PI_NAMEs: BYERS, DEREK E;GELMAN, ANDREW ERIC;GOSS, CHARLES ;HACHEM, RAMSEY  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acute;Adrenal Cortex Hormones;Affinity;allograft rejection;Allografting;Antibodies;Antibody Formation;Antibody Therapy;antibody-mediated rejection;Antithymoglobulin;B cell differentiation;Binding;Biological;C-reactive protein;Cause of Death;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Count;cell free DNA;Cell Proliferation;Cells;Cessation of life;Characteristics;Chronic;Clinical;Clinical Trials;Clinical Trials Design;Collagen;Communities;Conduct Clinical Trials;cytokine;Data;design;Development;Diagnosis;donor-specific antibody;Dose;efficacy evaluation;efficacy study;Endothelial Cells;Equilibrium;experience;Experimental Models;Failure;Fibroblasts;Functional disorder;Future;Gastroesophageal reflux disease;Helper-Inducer T-Lymphocyte;HLA Antigens;Human;IL2RA gene;IL2RB gene;Immunoglobulin G;Immunoglobulins;Immunosuppressive Agents;improved;improved outcome;Incidence;Individual;Infection;infection risk;Inflammatory;Inflammatory Response;Interleukin 6 Receptor;Interleukin-2;interleukin-21;Interleukin-6;Intravenous Immunoglobulins;Kidney;Kidney Transplantation;Link;Lung;lung allograft;Lung Diseases;lung injury;Lung Transplantation;Measurement;Measures;Membrane;Memory;Memory B-Lymphocyte;Monitor;Monoclonal Antibodies;mortality;Multicenter Studies;Multicentric Angiofollicular Lymphoid Hyperplasia;Mus;Myofibroblast;novel;Outcome;Pathogenesis;Patients;Persons;Pharmaceutical Preparations;Pharmacodynamics;Phase;Phase I Clinical Trials;Phase II Clinical Trials;Phenotype;Placebos;Plasma Exchange;Plasmablast;Play;prevent;Prevention;primary endpoint;Production;prospective;Randomized, Controlled Trials;receptor;Receptor Inhibition;Recurrence;Refractory;Regimen;Regulatory T-Lymphocyte;Reporting;response;rituximab;Role;Safety;safety assessment;safety testing;Schedule;secondary endpoint;Serious Adverse Event;Signal Transduction;Smooth Muscle Myocytes;Specificity;standard of care;Testing;Therapeutic;Therapeutic immunosuppression;Transplant Recipients;United States Food and Drug Administration;Vascular Smooth Muscle;Viral Respiratory Tract Infection

PROJECT_TITLE: A Phase 1 Clinical Trial of Siltuximab for the Treatment of Antibody-Mediated Rejection after Lung Transplantation


PI_NAMEs: LUTTY, GERARD ANTHONY (contact)

PROJECT_TERMS: Anesthesia procedures;Animal Model;Animals;Caring;Core Grant;Disease;disease phenotype;Disease Progression;Doctor of Philosophy;efficacy testing;Ensure;Equipment;Eye;Eye diseases;Faculty;Fostering;Funding;Generations;Genetic Engineering;Goals;Grant;imaging system;Microscope;Modeling;Monitor;Operating Rooms;Operative Surgical Procedures;Phenotype;Protocols documentation;Publications;Research;Research Personnel;Running;service organization;skills;Testing;Training;Treatment Efficacy;United States National Institutes of Health;Vision;Vision research;vision science;Zebrafish

PROJECT_TITLE: Animal Models Module


ADMINISTERING_IC: LM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Social Determinants of Health

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Research in biomedical and bioengineering careers increasingly relies on rapidly evolving domain-specific data analysis skills and the expert management of information and knowledge. There is a critical need for such preparation among urban students to fill the growing workforce requirements in biomedical informatics. This proposal’s goal is to reduce gender and race disparities in the biomedical, behavioral and clinical research workforce by targeting academically talented students who come from economically disadvantaged (ED) and/or underrepresented minority (URM) populations by providing them hands-on research experiences during summer and keep them motivated to pursue research as well as academic careers.

PI_NAMEs: JANGA, SARATH CHANDRA  (contact);PURKAYASTHA, SAPTARSHI

PROJECT_TERMS: Acceleration;Acute;Address;Adopted;Adoption;Appointment;Award;Bachelor's Degree;Behavioral Research;Bioinformatics;Biomedical Engineering;biomedical informatics;Biomedical Research;bridge program;career;career development;Clinical Research;cohort;college;Communities;Data;Data Analyses;Dedications;Degree program;design;Disadvantaged minority;economic disparity;Education;education pathway;education research;educational atmosphere;Environment;Evaluation;experience;Faculty;Financial Support;Funding;Gender;gender disparity;Goals;Graduate Degree;graduate student;hands on research;High School Student;Historically Black Colleges and Universities;improved;indexing;Indiana;Industry;Industry Collaboration;Informatics;informatics training;Information Management;innovation;Institution;interest;Internships;Intervention;Joints;Knowledge;Learning;learning outcome;Life;Low income;Master of Science;matriculation;Medical;medical schools;men;Mentors;Mentorship;Minority;Minority Groups;Minority-Serving Institution;Modeling;multidisciplinary;Multilingualism;Nature;news;Occupations;Output;Pathway interactions;pedagogical content;peer;peer coaching;Pharmacologic Substance;Policy Maker;Population;posters;Preparation;Private Sector;Process;programs;Public Health Informatics;Public Sector;Publications;Race;racial disparity;Recording of previous events;recruit;Research;Research Support;Research Training;resilience;role model;Scholars Program;Schools;Science;Science, Technology, Engineering and Mathematics;Self Efficacy;Site;skills;STEM field;Student recruitment;Students;summer internship;summer research;symposium;Talents;Underachievement;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Students;United States National Library of Medicine;Universities;virtual;Wages;Woman

PROJECT_TITLE: DataWiz-IN scholars program for Biomedical Informatics workforce in Indiana


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

PHR: Core Narrative The Bioinformatics and Biostatistics Core (Core B) will provide expert computational analysis for genome, transcriptome, epigenome and proteome data generated and studied in the Program. The Core will also provide expert Biostatistical support for experimental design and interpretation. All Projects will be supported by this Core.

PI_NAMEs: ZHANG, JINGHUI  (contact)

PROJECT_TERMS: Address;analytical tool;Animals;ATAC-seq;Automobile Driving;Bioinformatics;Biological Assay;Biological Models;Biological Process;Biometry;Biostatistics Core;bisulfite sequencing;Brain;Cells;Childhood;Childhood Brain Neoplasm;Childhood Cancer Genome Project;ChIP-seq;Classification;Cloud Computing;cloud platform;Computational Biology;computational pipelines;Computer Analysis;Coupled;Data;Data Analyses;data integration;data management;data quality;data resource;Data Set;data sharing;data to knowledge;Deposition;design;Developmental Process;Diffuse intrinsic pontine glioma;Dimensions;Discipline;Disease;Encyclopedia of DNA Elements;Ensure;Epigenetic Process;epigenome;epigenomics;exome sequencing;experimental analysis;Experimental Designs;experimental study;Functional dependence;genetic signature;genome analysis;genomic data;Genomics;Glioma;Goals;high dimensionality;High Performance Computing;hindbrain;Human;Infrastructure;Medulloblastoma;member;Methods;Methylation;Molecular;Molecular Profiling;mouse model;multimodality;Mutation;Neoplasms;neuropathology;novel;Oncogenic;Pathogenesis;Pathway Analysis;Pathway interactions;Phenotype;phenotypic data;Play;Process;Program Research Project Grants;programs;Proteome;Proteomics;public database;Publishing;Quality Control;Regulation;Reproducibility;Research Design;Research Project Grants;ribosome profiling;Role;Saint Jude Children's Research Hospital;Sample Size;Sampling;Scientist;Secure;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;Statistical Data Interpretation;Subgroup;The Cancer Genome Atlas;Therapeutic Intervention;therapeutic target;transcriptome;transcriptome sequencing;transcriptomics;treatment response;tumor;tumorigenesis;Universities;Visualization software;Washington;whole genome;Work

PROJECT_TITLE: Core B: Bioinformatics and Biostatistics Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Nanotechnology;Neurosciences

PI_NAMEs: RANGARAMANUJAM, KANNAN  (contact)

PROJECT_TERMS: Animal Model;Animals;Basic Science;Biological;Cell Culture Techniques;Cells;Clinical Research;clinical translation;Collaborations;Communities;Core Grant;Cultured Cells;Development;Devices;Doctor of Philosophy;Dose;Dose Limiting;Drug Delivery Systems;drug discovery;Eye;Eye diseases;eye dryness;Faculty;Gene Delivery;Gene Expression;Genes;Genetic Engineering;Glaucoma;Grant;Human;imaging approach;In Vitro;in vivo;interest;Legal patent;Licensing;nanomedicine;nanoparticle;nanoscale;Nanotechnology;novel imaging technology;novel therapeutic intervention;novel therapeutics;Nucleic Acids;Optic Nerve Injuries;Outcome;particle;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;Phenotype;pre-clinical;Proteins;Publications;Research;Research Personnel;Resources;Retinopathy of Prematurity;Services;Site;small molecule;System;targeted delivery;Technology;technology platform;Therapeutic;Therapeutic Effect;therapeutic target;tissue culture;Tissues;tool;Toxic effect;Transfection;United States National Institutes of Health;vector;Vision research;vision science;Work

PROJECT_TITLE: Drug Delivery and Nanotechnology Module


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: MORRISON, JOHN C (contact)

PROJECT_TERMS: Academic support;Administrator;Awareness;Basic Science;Behavioral;bench to bedside;bioimaging;Biometry;Biostatistics Core;Budgets;career;Clinical;clinical practice;Clinical Research;Collaborations;Communication;Communities;Confocal Microscopy;Core Facility;cost;Data;Diagnosis;Doctor of Philosophy;Electronics;Equipment;equipment acquisition;Equity;Expenditure;experience;Eye;Eye diseases;Faculty;Feedback;Fostering;Funding;Funding Opportunities;Gene Expression;genetic manipulation;Genetic Models;Goals;Grant;Human;improved;Individual;instrumentation;Laboratories;Leadership;meetings;member;Mentors;Mentorship;Monitor;Neurosciences;Ophthalmology;Productivity;professor;programs;Proteomics;Publications;Research;research faculty;Research Infrastructure;Research Personnel;Resource Allocation;Role;Running;Scientist;Services;Speed;Structure;Surveys;Technology;Translations;Vision;Vision research;vision science


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: MORGANS, CATHERINE W (contact)

PROJECT_TERMS: Acceleration;Animals;bioimaging;confocal imaging;Confocal Microscopy;Core Facility;Data;Development;Eye;fluorescence imaging;Fluorescence Microscopy;Funding;graduate student;Image;imaging capabilities;Imaging Device;imaging system;in vivo imaging;Individual;instrument;instrumentation;Maintenance;Microscope;microscopic imaging;operation;Ophthalmology;Optical Coherence Tomography;Postdoctoral Fellow;Principal Investigator;Publications;Research;Research Personnel;retinal imaging;Rodent;structural imaging;student participation;System;Technical Expertise;Technology;Training;training opportunity;translational progress;Vision;Vision research

PROJECT_TITLE: Bio-Imaging and Confocal Microscopy


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

PHR: CORE NARRATIVE A central pathology facility where expertise in histological methods and interpretation is concentrated for the benefit of program investigators is a fundamental element of our Program and is designated the Program Neuropathology Core (Core C).

PI_NAMEs: ORR, BRENT ALAN (contact)

PROJECT_TERMS: Adherence;Anatomy;Animal Model;animal tissue;Area;Biological Assay;Brain;Brain Neoplasms;Budgets;Central Nervous System Neoplasms;Childhood Brain Neoplasm;Childhood Central Nervous System Neoplasm;Childhood Glioma;Chromogenic in situ Hybridization;Classification;Clinical;comparative;Core Facility;Data;Development;Developmental Process;Diagnosis;Diffuse intrinsic pontine glioma;disease model;DNA Sequence Alteration;Elements;Evaluation;experience;Experimental Designs;experimental group;Fluorescence;Foundations;Gene Mutation;Genes;Genetic;Goals;Hematoxylin and Eosin Staining Method;hindbrain;Histologic;Histopathology;Human;human disease;Human Resources;human tissue;Immunohistochemistry;Immunophenotyping;improved;instrument;interest;Investigation;Laboratories;Medulloblastoma;Methods;Modeling;Molecular;molecular marker;Molecular Profiling;Morphology;mouse model;mRNA Expression;Mus;Mutation;Neoplasms;neuropathology;new therapeutic target;novel;Pathologic;Pathologist;Pathology;Patients;Phenotype;Process;programs;protein biomarkers;Protocols documentation;Publications;Reagent;Research;Research Personnel;Research Support;Sampling;Secure;Stains;Standardization;Techniques;Tissue Microarray;Tissue Sample;Tissues;treatment stratification;tumor;tumorigenesis;Variant;Work

PROJECT_TITLE: Core C: Neuropathology Core


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics

PI_NAMEs: ACOTT, TED S (contact)

PROJECT_TERMS: Alternative Splicing;Area;Basic Science;behavior change;Binding;Biochemistry;Biological Assay;Biomedical Research;Bread;Butter;Cell Physiology;Cells;Cellular biology;Core Facility;CRISPR/Cas technology;Data;Disease;disease model;Dominant-Negative Mutation;Elements;Enzyme-Linked Immunosorbent Assay;experience;Experimental Designs;Eye;falls;Foundations;Funding;Future;Gene Expression;Gene Expression Profiling;gene product;Gene Transfer;Genes;Genetic;genetic manipulation;genetic variant;Immunologics;Individual;Infection;instrument;instrumentation;Intention;Investigation;knock-down;laser capture microdissection;Measures;Messenger RNA;Methods;Modernization;Modification;Molecular;Molecular Biology;mutant;Ophthalmology;Outcome;overexpression;Pattern;Process;promoter;Property;Protein Chemistry;protein purification;Proteins;Quantitative Reverse Transcriptase PCR;Recombinants;Reporter;Research;Research Design;Research Personnel;Resources;RNA Interference;RNA Splicing;Services;Spliced Genes;stem cells;success;Time;Tissues;Transcriptional Regulation;Transfection;treatment comparison;treatment effect;treatment group;Variant;Vertebral column;Viral;Viral Genes;Vision;vision science;Western Blotting

PROJECT_TITLE: Gene Expression and Manipulation


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Macular Degeneration;Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: WIRTZ, MARY K (contact)

PROJECT_TERMS: Age;Age related macular degeneration;Algorithms;Angiography;Animal Model;Applications Grants;Basic Science;Biocompatible Materials;Bioinformatics;Biological;Biometry;Biostatistics Core;Blood specimen;Cadaver;Cell Culture Techniques;Cells;Chemistry;Clinical Research;Clinical Trials;Complement;Complex;complex data;Core Facility;cost effective;Cultured Cells;Data;Data Analyses;Data Set;data submission;Dedications;Dideoxy Chain Termination DNA Sequencing;Disease;DNA;DNA sequencing;Ensure;Environment;Exposure to;Eye;Eye diseases;Family;Family suidae;Fibroblasts;Funding;Gene Chips;Gene Expression;Genes;Genetic;genetic analysis;Genetic Models;genetic pedigree;genetic variant;Genotype;Glaucoma;Goals;Grant;Health;Human;Hydrophthalmos;individual variation;innovation;instrument;interest;Lymphocyte;Methods;Modeling;Molecular;Molecular Genetics;Mus;nonhuman primate;novel;Ophthalmology;Optical Coherence Tomography;Oregon;Pathway interactions;Patients;Peripheral;Phase;Phenotype;precision medicine;Primary Cell Cultures;Primary Open Angle Glaucoma;Proteomics;Publications;Rattus;Research;Research Design;Research Personnel;research study;Resources;Retinal Dystrophy;Retinitis Pigmentosa;Retinopathy of Prematurity;Saliva;Sampling;Science;Scientist;Services;Sjogren's Syndrome;Stargardt's disease;Statistical Data Interpretation;success;Techniques;Time;Tissues;Trabecular meshwork structure;transcriptome sequencing;Translating;Universities;Uveitis;Vertebral column

PROJECT_TITLE: Genetic Models of Ocular Disease and Biostatistics


ORG_CITY: KNOXVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

PHR: Force generating motor proteins drive a plethora of essential processes in the cells of the body and must be appropriately regulated for their functions. We investigate the specific function and regulation of kinesin motors in mammalian cilia, which are specialized organelles critical for normal development and physiology. This work investigates fundamental cellular processes that are known to malfunction in certain human diseases and may thus reveal novel cellular treatment targets.

PI_NAMEs: ENGELKE, MARTIN F. (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Back;base;Biochemical;Cell membrane;Cell Physiology;Cells;Cellular Assay;chemical property;Chlamydomonas;Cilia;ciliopathy;Classification;Development;Disease;Dynein ATPase;Engineering;experimental study;Genome engineering;human disease;In Vitro;Intracellular Transport;Kinesin;Length;Maintenance;Mastigophora;Microscopy;Microtubules;Mitotic spindle;Modeling;morphogens;Motor;Nasal cavity;novel;Organelles;physical property;Physiology;Process;Protein Engineering;Proteins;recruit;Regulation;Renal tubule structure;Research Personnel;Resolution;Sensory;Stimulus;Structure;System;therapy development;Time;Tissues;Training;Tubulin;Urine;Work

PROJECT_TITLE: Function and regulation of kinesin motors in cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: DAVID, LARRY L (contact)

PROJECT_TERMS: age related;Biological;Cataract;Cell Physiology;Center Core Grants;Chemicals;Complement;Complex Mixtures;Core Facility;Cornea;Corneal pain;crosslink;Data;Deposition;Deuterium;Development;Disease;Emerging Technologies;Event;Exfoliation Syndrome;experience;experimental study;Eye diseases;eye dryness;Funding;Glaucoma;Health Sciences;Hydrogen;improved;instrumentation;lens;Lens development;Liquid substance;mass spectrometer;Mass Spectrum Analysis;Measures;Membrane;Membrane Proteins;Methods;Modernization;Modification;National Eye Institute;Ophthalmology;Oregon;Phosphopeptides;Phosphorylation;Physiologic Intraocular Pressure;Post-Translational Protein Processing;Predisposition;Process;Productivity;protein crosslink;protein folding;protein protein interaction;protein structure;Proteins;Proteome;Proteomics;Proteomics Shared Resource;Research;Research Personnel;Resolution;Retina;Retinal Diseases;Structure;Techniques;Technology;Thyroid Gland;Tissues;Trabecular meshwork structure;Transgenic Animals;Universities;Vision;Vision research

PROJECT_TITLE: Proteomics and Mass Spectrometry


ORG_CITY: CHICAGO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: OVERALL – PROJECT NARRATIVE The presence of major cancer health inequities in Chicago is well-documented. The Chicago Cancer Health Equity Collaborative (ChicagoCHEC), a comprehensive cancer research partnership between the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, the University of Illinois at Chicago, and Northeastern Illinois University, builds upon its productive first U54 award to continue strengthening collaborative infrastructure and implementing innovative cancer research, education, and outreach programs aimed at eliminating Chicago’s deeply-engrained cancer disparities.

PI_NAMEs: CIECIERSKI, CHRISTINA ;FEINGLASS, JOSEPH M;FILUS, LIDIA ;FITZGIBBON, MARIAN L.;SIMON, MELISSA A. (contact);STEWART, JOHN H

PROGRAM_OFFICER_NAME: SAN MIGUEL-MAJORS, SANDRA L

PROJECT_TERMS: Acceleration;Advanced Malignant Neoplasm;African American;anti-cancer research;Applications Grants;Award;cancer health disparity;Cancer health equity;Cancer Research Infrastructure;Cancer Research Project;career;Chicago;Circadian Rhythms;Cities;Clinical;Collaborations;Communities;community engagement;Community Outreach;community partners;Comprehensive Cancer Center;Decision Making;Dedications;disability;DNA Double Strand Break;Double Strand Break Repair;early-career faculty;Education;Education and Outreach;education research;empowerment;Evaluation;experience;Extramural Activities;Faculty;forging;Fortification;Funding;Funding Mechanisms;Generations;Goals;Grant;gut microbiome;Health Disparities Research;health disparity populations;health inequalities;Hematopoietic Stem Cell Transplantation;high risk;Hispanic-serving Institution;Illinois;improved;Infrastructure;innovation;Institution;Lead;Leadership;Long-Term Effects;lung cancer screening;Malignant Neoplasms;men;Mentors;mHealth self-management;Midwestern United States;Minority;minority student;Mission;next generation;oral microbiome;outreach;outreach program;Peer Review;Pilot Projects;Positioning Attribute;Prevention;Productivity;programs;Publications;rapid growth;Records;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Science;Scientist;social;Students;Survivors;survivorship;tool;Training;Translational Research;Transplant Recipients;Underrepresented Populations;Underrepresented Students;underserved community;Underserved Population;Universities;Variant

PROJECT_TITLE: 1/3: The Chicago Cancer Health Equity Collaborative (ChicagoCHEC)


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: SIMON, MELISSA A. (contact)

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Pediatric;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: There is pressing need to develop and evaluate novel approaches to close the enourmous gap in cascade genetic risk evaluation (GRE) in families with hereditary cancer syndromes. We propose a randomized trial of 900 cancer patients diagnosed in 2018-2019 in Georgia and California with a clinically significant pathogenic variant detected by genetic testing that will offer initial GRE and testing to relatives to evaluate the effects of the level of personalized genetic risk navigation support and the price offered to the relative for the genetic test on receipt of initial GRE and patients’ and relatives’ appraisal of communication and engagement. The findings of this study have the potential to transform prevention precision oncology in the community with broad applications in practice.

PI_NAMEs: AN, LAWRENCE CHIN-I;KATZ, STEVEN J. (contact);KURIAN, ALLISON W.

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Adult;Affect;Attitude;California;Cancer Burden;cancer diagnosis;Cancer Patient;cancer prevention;cancer risk;Cancer-Predisposing Gene;Caring;Clinical;clinically actionable;clinically relevant;clinically significant;cohort;Communication;Communication Tools;Communities;Complex;Conflict (Psychology);contextual factors;cost;cost effective;Counseling;data infrastructure;Decision Making;design;Diagnosis;disease-causing mutation;Early Diagnosis;Education;Eligibility Determination;Enrollment;Evaluation;evaluation/testing;Family;family genetics;Family member;Future;Genetic;Genetic Counseling;genetic panel test;Genetic Risk;genetic testing;Guidelines;Health;health care disparity;Hereditary Malignant Neoplasm;Hereditary Neoplastic Syndromes;high risk;Human;improved;Incentives;individualized prevention;interest;Intervention Trial;Malignant Neoplasms;Medical;neoplasm registry;novel strategies;Outcome;Patients;Population;population based;Positioning Attribute;practical application;precision genetics;precision oncology;Prevention;Prevention strategy;Price;primary outcome;Professional counselor;programs;Randomized;randomized trial;Relative Risks;Reporting;Resources;Risk Reduction;Sampling;Screening for cancer;Second Degree Relative;Services;social factors;Specialist;Subgroup;Technology;Test Result;Testing;therapy design;tool;variant detection;virtual;virtual platform

PROJECT_TITLE: A population-based virtual solution to reduce gaps in genetic risk evaluation and management in families at high risk for hereditary cancer syndromes:  The Georgia-California GeneLINK Trial


PI_NAMEs: HITSMAN, BRIAN L (contact)

PROJECT_TERMS: Achievement;Advisory Committees;analytical tool;anti-cancer research;Award;Benchmarking;cancer health disparity;Cancer health equity;Cancer Research Project;career;career development;catalyst;Chicago;Clinical Sciences;Communication;community engaged approach;Consultations;Counseling;Data;Data Analyses;data tools;Decision Making;Development;early-career faculty;Educational workshop;Ensure;Evaluation;experience;Faculty;faculty mentor;Foundations;Funding;Funding Mechanisms;Goals;Grant;Health;health disparity;improved;Incubators;Infrastructure;innovation;Institution;Intervention Studies;Knowledge;Leadership;Logic;mathematical model;member;Mentors;Mentorship;Mission;Modeling;Monitor;novel;Outcome;Performance;Pilot Projects;Process;process improvement;Program Development;programs;Progress Reports;Quasi-experiment;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Resources;Running;skills;Statistical Data Interpretation;Structure;Surveys;Time;Translational Research;Universities;Work

PROJECT_TITLE: Planning and Evaluation Core


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Repetitive mild traumatic brain injuries (rmTBIs) can lead to long-term cognitive changes, neurodegeneration, and dementia. The mechanisms responsible for the long-term effects of repetitive mTBI are not well understood and effective therapeutic strategies are lacking. This proposal will use a physiologically relevant mouse model of rmTBI to determine if stress response in neurons is responsible for triggering neuroinflammation, loss of cognitive function, and reduction in cerebral blood flow.

PI_NAMEs: BUCKLEY, ERIN MCGUIRE;WOOD, LEVI BENJAMIN (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acute;adverse outcome;Affect;Attenuated;Automobile Driving;biological adaptation to stress;Biological Markers;Biomechanics;Blood flow;Blood Vessels;Brain;cell type;Cerebrovascular Circulation;cerebrovascular reactivity;Chronic;Clinical Research;Closed head injuries;Cognition;Cognitive;cognitive change;Cognitive deficits;cognitive function;Core-Binding Factor;Coupled;cytokine;Data;Dementia;design;Disease associated microglia;Early identification;emotional symptom;Functional disorder;Genetic;Goals;Hippocampus;IL17 gene;immune cell infiltrate;Immune signaling;Immunohistochemistry;Impaired cognition;improved;Induced Neurons;Inflammatory;inflammatory marker;inhibitor;Injections;Injury;insight;intraperitoneal;ITGAX gene;knock-down;Knock-out;Knockout Mice;Knowledge;Link;Long-Term Effects;MAP Kinase Gene;Measurement;Measures;Mediating;Microglia;mild traumatic brain injury;Modeling;Molecular;morris water maze;mouse model;Mus;Nerve Degeneration;neural;Neurobehavioral Manifestations;neuroinflammation;Neurologic;Neurologic Dysfunctions;Neurologic Symptoms;Neuronal Dysfunction;Neurons;Nitric Oxide;Optics;Outcome;outcome prediction;overexpression;p38 Mitogen Activated Protein Kinase;Pathway interactions;Patients;Phagocytes;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphorylation;physical symptom;Physiological;Pre-Clinical Model;preclinical study;Production;promoter;psychological symptom;PTPRC gene;Regulation;Research;response;response to injury;Role;Severities;Signal Transduction;Stress;success;Synapsins;Systems Analysis;Tail Suspension;Tamoxifen;Techniques;Testing;therapeutically effective;Tissues;transcriptome sequencing;transcriptomics;Transgenic Mice;Traumatic Brain Injury;vector;Wild Type Mouse;Wood material;Work

PROJECT_TITLE: Role of Neuronal p38 MAPK After Repetitive Mild TBI

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Cancer;Pediatric;Social Determinants of Health

PI_NAMEs: YANEZ, BETINA  (contact)

PROJECT_TERMS: Address;African American;anti-cancer research;Area;Attention;cancer health disparity;Cancer health equity;Cancer Science;career;career development;career preparation;Chicago;Cities;college;Communities;community college;community engagement;community partners;Comprehensive Cancer Center;curriculum development;design;Development;disability;Disparity;Diverse Workforce;diversity and equity;Dryness;Education;education research;Educational Activities;Educational Curriculum;Educational Status;Ensure;Ethnic Origin;Evaluation;experience;Faculty;Fortification;Fostering;Foundations;Funding;Gender;Goals;Grant;Health Disparities Research;health disparity;Healthcare;high school;Hispanic;Illinois;Immersion;improved;Influentials;Institution;interest;Internships;laboratory experience;Laboratory Research;life-long learning;Link;lower income families;Malignant Neoplasms;Medical Students;Medicine;member;Mentors;Minority;minority student;Not Hispanic or Latino;peer;Postdoctoral Fellow;Program Evaluation;programs;Race;Readiness;Recording of previous events;Research;research faculty;Research Personnel;Research Project Grants;Science;science education;Science, Technology, Engineering and Mathematics Education;skills;social culture;Social Network;Structure;Student recruitment;Students;success;summer program;summer research;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;university student;Work

PROJECT_TITLE: Research Education Core


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_CITY: LOUISVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 and has resulted in ongoing pandemic, tragic loss of life, and dire economic consequences. COVID-19 patients with severe and critical disease also develop pulmonary inflammation and abnormal bleeding problems. We propose to study the mechanisms underlying these problems and develop a novel therapeutic approach; this will help us achieve rapid progress toward overcoming the challenges of COVID-19.

PI_NAMEs: HUANG, JIAPENG ;URIARTE, SILVIA M;YAN, JUN  (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: 2019-nCoV;Acute Lung Injury;Acute Respiratory Distress Syndrome;Alpha Granule;Antibodies;antimicrobial;Apoptosis;Bilateral;Blood capillaries;Blood Coagulation Disorders;Blood specimen;Bronchoalveolar Lavage Fluid;cell injury;Cells;Chemotaxis;Chimeric Proteins;Circulation;Clinical;Coagulation Process;COVID-19;COVID-19 patient;COVID-19 severity;COVID-19/ARDS;cytokine;cytokine release syndrome;Cytoplasmic Granules;cytotoxic;Data;density;design;Diffuse;Disease;Disease Outcome;Disease Progression;Economics;Endothelial Cells;exhaustion;Exocytosis;Exocytosis Inhibition;experience;extracellular;FCGR3B gene;Fibrin fragment D;Fibrinogen;Functional disorder;Gene Expression;Hemorrhage;Histologic;Hypoxia;Immune;immune activation;immunoregulation;immunothrombosis;Impairment;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;insight;Interleukin-6;Life;Link;Lower respiratory tract structure;Lung;lung injury;Lymphocyte;Measures;Mediating;Modeling;mouse model;neutrophil;Neutrophil Infiltration;novel;novel marker;novel therapeutic intervention;Outcome;pandemic disease;pathogen;pathogenic virus;Patients;Pattern;Perfusion;peripheral blood;Phagocytosis;Plasma;Platelet Activation;Platelet Count measurement;Play;Pneumonia;Population;Predisposing Factor;prevent;Proteome;Proteomics;Pulmonary Inflammation;Reactive Oxygen Species;Respiratory Burst;response;Role;Sampling;SARS-CoV-2 negative;Severity of illness;Structure of parenchyma of lung;Surface;T-Lymphocyte;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;Thrombus;Time;TNF gene;transcriptome sequencing;transcriptomics;treatment effect;Venous;ventilation;Viral

PROJECT_TITLE: Low Density Neutrophils Link Inflammation and Coagulopathy in COVID-19

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: GIACHELLO, AIDA L (contact)

PROJECT_TERMS: Acceleration;Achievement;Address;Advanced Malignant Neoplasm;anti-cancer research;Area;Award;Awareness;cancer care;cancer education;cancer health disparity;Cancer health equity;cancer prevention;Cancer Survivor;Cancer Survivorship;cancer therapy;Chicago;Cities;citizen science;Clinical;Clinical Trials;Collaborations;Communities;community engaged approach;community engagement;Community Health;Community Networks;community organizations;Community Outreach;community partners;community partnership;community-centered;Comprehensive Cancer Center;Continuity of Patient Care;Death Rate;Development;disability;Disabled Persons;Disparity;Dissemination and Implementation;Early Diagnosis;Education;Education and Outreach;education research;Educational Activities;ethnic minority;Evaluation;Event;evidence base;Evidence based practice;experience;Faculty;forging;Fostering;Funding;gender minority community;Geographic Locations;Grant;Health;health disparity populations;Health Educators;health equity;Health equity research;Health Fairs;Human;Illinois;Immersion;improved;Incidence;Individual;Inequity;innovation;Institution;Interview;Lead;Leadership;Linguistics;literacy;Localized Malignant Neoplasm;Low income;Malignant Neoplasms;Maps;member;men of color;minority communities;mortality;Needs Assessment;Neighborhoods;neoplasm registry;outreach;Outreach Research;peer;peer coaching;Penetrance;Persons;Phase;Population;Positioning Attribute;Prevention;process evaluation;Productivity;programs;racial minority;Recommendation;Research;Research Personnel;Research Project Grants;Resources;response;screening;Secure;Services;Sexual and Gender Minorities;Students;Surveys;survivorship;symposium;tool;underserved community;Underserved Population;Universities;Vulnerable Populations;Work

PROJECT_TITLE: Outreach Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Mental Health;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_DEPT: MISCELLANEOUS

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Despite affecting one out of three women worldwide, to date there has been little rigorous research on the efficacy of large-scale interventions to reduce and prevent GBV. The proposed study evaluates the impact of a novel policy intervention in rural Peru aimed at reducing GBV and changing social norms, and compares the relative efficacy of two standard approaches to GBV programming: i) a home-based approach in which facilitators visit households to increase awareness of GBV, and ii) a group-based approach, in which facilitators organize gender-segregated group sessions in communities to discuss domestic violence and masculinity using media dramatizations of social problems. The study disentangles the short- and long-term effects of each treatment separately, as well as their interaction, on incidence and awareness of GBV, mental health, social norms regarding gender roles and GBV, agency, empowerment, attitudes and behaviors.

PI_NAMEs: ALDANA, URSULA T.;FIELD, ERICA M (contact);SCHUBIGER, LIVIA

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Address;Affect;Africa;Area;Asia;Attitude;Awareness;Behavior;Behavior Control;Behavioral;Child;Communities;Community Health;Consensus;Control Groups;cost;Cost Analysis;cost effectiveness;Country;Data;design;Dimensions;Domestic Violence;Economics;Education;Educational workshop;Effectiveness;effectiveness measure;empowerment;Evaluation;experience;Experimental Designs;Exposure to;Facilities and Administrative Costs;Family;Female;Gender;Gender Role;gender-based violence;Goals;Government Programs;Health;health seeking behavior;Home;Household;Impact evaluation;Incidence;Individual;Infrastructure;insight;instrument;Intervention;intervention effect;Knowledge;Latin American;Learning;Legal system;Literature;Long-Term Effects;male;Manuals;Measures;media use;men;Mental Health;Methodology;novel;Outcome;outreach;Patient Self-Report;peer;Peru;Peruvian;Policies;Policy Making;Politics;Positioning Attribute;prevent;Prevention;Privacy;Privatization;Productivity;Program Effectiveness;programs;Public Health;Randomized;Randomized, Controlled Trials;Reporting;Research;Research Design;Risk;Risk Factors;Running;Rural;Sampling;scale up;segregation;social;social capital;Social Change;social norm;Social Problems;successful intervention;Surveys;Techniques;Testing;Training;Training Programs;Treatment Efficacy;Violence;virtual;Visit;volunteer;welfare;Woman;Women's Group

PROJECT_TITLE: Training Leaders to Prevent and Reduce Domestic Violence in Their Communities: Experimental Evidence From Peru

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Social Determinants of Health

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Cancer genomics helps advance cancer treatments by identifying how DNA and genes differ in cancer cells. Greater participant engagement in genomics studies is needed to address gaps in knowledge among rare cancers, highly lethal cancers, cancers with an early age of onset, cancers with high disparities in incidence/mortality, and cancers among under-represented minorities. The Participant Engagement and Cancer Genome Sequencing (PE-CGS) Network will promote participant engagement in genomics studies. As the Coordinating Center of this Network, we will help with coordination and community outreach, identify best- practices in participant engagement and genomics, and address health disparities in cancer genomics.

PI_NAMEs: BRIDGES, JOHN F. (contact);KIM, HYOSHIN

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Age of Onset;Cancer Biology;cancer cell;cancer genome;cancer genomics;cancer health disparity;cancer therapy;Cells;Clinical;clinical center;Clinical Data;Clinical Sciences;Collaborations;collected works;college;Common Data Element;Communication;community based participatory research;community engagement;Community Outreach;Comprehensive Cancer Center;Controlled Vocabulary;Data;Data Collection;data standards;data submission;Databases;Development;Diagnostic Procedure;Disparity;Dissemination and Implementation;DNA;DNA Sequence;DNA Sequence Alteration;Documentation;Education;Ensure;epidemiologic data;Equity;ethnic minority;experience;Faculty;FAIR principles;Fostering;Future;Gene Expression;Genes;genome sequencing;genomic data;genomic profiles;Genomics;Goals;health disparity;health equity promotion;improved;Incidence;innovation;insight;Ions;Knowledge;Malignant Neoplasms;Medicine;meetings;member;mortality;neoplastic cell;next generation sequencing;novel;Office of Administrative Management;Ohio;outreach;Participant;patient engagement;Policies;Population;Positioning Attribute;Postdoctoral Fellow;preference;Prevention strategy;Process;programs;Public Relations;racial minority;rare cancer;Research;Research Personnel;Research Support;Resources;Route;Scholars Program;Scientist;Site Visit;STEM research;success;support network;Technology;The Cancer Genome Atlas;Training;Translational Research;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;web site;Work;working group

PROJECT_TITLE: Participant Engagement and Cancer Genome Sequencing (PE-CGS): Coordinating Center


NIH_SPENDING_CATS: Cancer

ORG_CITY: NEW YORK

ORG_NAME: CITY COLLEGE OF NEW YORK

ORG_STATE: NY

PHR: This is a renewal application for years 17-21 of this summer research training program in Cancer Epidemiology for public health graduate students. This is a 12-week summer field research experience in foreign countries and among minority populations in the U.S. Our evaluation in the current grant period shows a high level of productivity for our graduates, particularly in their publications and their career directions. The implementation of this program will provide a source of skilled professionals needed to carry out cancer epidemiology research in special populations.

PI_NAMEs: SOLIMAN, AMR  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Accreditation;Advisory Committees;Africa;Asia;cancer epidemiology;career;career development;Country;Data;Development;Discipline;doctoral student;Education;Educational workshop;Epidemiologist;Epidemiology;epidemiology study;ethnic diversity;Europe;Evaluation;experience;Faculty;faculty mentor;Funding;Future;graduate student;Grant;Infrastructure;innovation;Latin America;Malignant Neoplasms;Manuscripts;Mentors;Mentorship;Michigan;Middle East;Migrant;Minority Groups;Nebraska;New York;Outcome;Paper;Positioning Attribute;Process;Productivity;programs;Public Health;Publications;Publishing;Qualifying;recruit;Research;Research Training;Schools;Site;skills;Source;Special Population;Students;summer research;Training Programs;Writing

PROJECT_TITLE: Cancer Epidemiology Education in Special Populations (CEESP)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: Princeton

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative In recent years precision oncology approaches based on molecular changes in an individual patient’s tumor have emerged as a promising new approach to diagnosis and treatment of cancer. However, these approaches are challenged by the fact that tumors are a heterogeneous collection of cells that change over time and in response to treatment. We will develop advanced software and powerful data analytic tools that will enable researchers to characterize the heterogeneity within tumors with high accuracy, enabling greater precision in cancer diagnosis and treatment.

PI_NAMEs: RAPHAEL, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Algorithmic Software;Algorithms;analytical tool;cancer cell;Cancer Center;cancer diagnosis;Cancer Patient;cancer therapy;Cells;Chromosomal Rearrangement;Cloud Computing;cluster computing;cohort;Collaborations;Collection;combinatorial;Complex;Computer software;computerized tools;Computers;Data;Data Analyses;Data Analytics;data format;Development;Diagnosis;DNA;DNA Sequence;DNA sequencing;Documentation;driver mutation;Dropout;Environment;epigenomics;Evolution;exome sequencing;Genome;Genomics;Heterogeneity;Individual;individual patient;insight;interactive tool;Libraries;Malignant Neoplasms;Mathematics;Measurement;Modeling;Molecular;Multiple Anatomic Sites;Mutation;Mutation Analysis;Names;Neoplasm Metastasis;neoplastic cell;Normal Cell;novel strategies;Nucleotides;open source;Output;Patients;Pattern;Phylogenetic Analysis;Phylogeny;precision medicine;precision oncology;Primary Neoplasm;Process;reconstruction;Recording of previous events;Recurrence;Research Personnel;Resistance;resistance mechanism;Resolution;Running;Sampling;sequencing platform;single cell sequencing;Single Nucleotide Polymorphism;software development;Software Tools;Somatic Mutation;sound;Statistical Algorithm;Structure;targeted sequencing;Technology;Testing;Time;tool;Training;transcriptome sequencing;treatment response;tumor;tumor heterogeneity;user friendly software;user-friendly;whole genome

PROJECT_TITLE: Comprehensive and Robust Tools for Analysis of Tumor Heterogeneity and Evolution


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Prevention;Substance Misuse

ORG_CITY: BROOKLYN

ORG_DEPT: PSYCHIATRY

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

PHR: PROJECT NARRATIVE The overarching goal of this proposal is to understand the genetic relationships between Substance Use Disorders (SUD, i.e., alcohol, nicotine, cannabis, opioid) and Posttraumatic Stress Disorder (PTSD) while increasing representation of individuals of diverse ancestry in psychiatric genetics research. The immense framework of the Psychiatric Genomics Consortium (PGC) will be used to allow for scientific collaboration, phenotypic harmonization across thousands of participants through the PGC-PTSD and PGC-SUD workgroups, and for building upon the success of each group in ancestral diversity. This research will increase understanding of the etiology of PTSD and SUD, informing prevention and intervention efforts tailored to those with co-occurring PTSD and SUDs and moreover will increase inclusion of individuals of African and Latinx descent in large-scale genome-wide association studies.

PI_NAMEs: AMSTADTER, ANANDA B;MEYERS, JACQUELYN LEIGH (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: African;Age of Onset;Alcohol consumption;alcohol use disorder;Alcohols;Cannabis;Categories;Characteristics;Clinical;cohort;Collaborations;Communities;comorbidity;Data;data acquisition;data harmonization;Disease;Equation;Etiology;Feeling suicidal;Genes;Genetic;genetic architecture;Genetic Research;Genetic Risk;Genetic Techniques;genome wide association study;genome-wide;genomic variation;Genomics;Goals;Heritability;Individual;Intervention;Latinx;marijuana use disorder;Measures;Mendelian randomization;Methods;Modeling;Molecular;Nature;Nicotine;novel;Observational Study;Opioid;opioid use disorder;Participant;Pathway interactions;Phenotype;phenotypic data;physical conditioning;Population;Population Heterogeneity;Post-Traumatic Stress Disorders;Prevention;Prognosis;psychiatric genomics;psychogenetics;Public Health;public health relevance;Randomized;Research;Risk;risk sharing;Sampling Studies;Science;Severities;Sex Differences;Statistical Methods;Structure;substance use;Substance Use Disorder;success;Symptoms;Testing;trait;Trauma;Twin Studies;Work

PROJECT_TITLE: Genetic Comorbidity of PTSD and Substance Use Disorders in Diverse Populations.

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative Triple negative breast cancer (TNBC) makes up to 20% of breast cancer diagnoses, with a 5-year survival as low as 11% for late-stage metastatic disease. This research proposal aims to study JAG1-mediated signaling as a potential target for TNBC metastatic spread by specifically focusing on tumor-endothelial interactions during tumor cell extravasation from circulation into secondary organs. Integrated into this proposal is a clinical educational plan and a bi-directional student-patient partnership.

PI_NAMEs: GORDON, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Adhesions;Adjuvant Chemotherapy;Affect;aggressive breast cancer;Binding;Blood;Blood capillaries;Blood Vessels;Breast Cancer Cell;breast cancer diagnosis;breast cancer metastasis;Breast Cancer Patient;cancer cell;cancer subtypes;cancer type;candidate identification;Cell Adhesion;Cell Communication;Cell surface;Cells;Circulation;Clinical;clinically actionable;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Consensus;CRISPR/Cas technology;Data;Disease;Distant;Distant Metastasis;Drops;Education;education planning;effective therapy;Elements;Endothelial Cells;Endothelium;expectation;Exposure to;Extravasation;Fellowship;Future;Gene Expression;Gene Expression Profile;Genetic Complementation Test;Genetic Transcription;Hematogenous;ICAM1 gene;improved;In Vitro;in vivo;Injections;insight;Invaded;knock-down;Knock-out;Leukocytes;Ligands;Link;Liquid substance;Localized Disease;Lung;Lymphatic;Malignant Breast Neoplasm;Mediating;Metastatic breast cancer;Microfluidics;migration;Modeling;molecular subtypes;Molecular Target;mortality;Mus;Neoplasm Metastasis;neoplastic cell;new therapeutic target;notch protein;novel;Oncology;Operative Surgical Procedures;Organ;Outcome;paracrine;Pathway interactions;Patients;Phenotype;Physicians;programs;Proteins;Research;Research Proposals;Role;Scientist;Series;shear stress;Signal Transduction;skills;Students;Survival Rate;System;Tail;Testing;Therapeutic;Therapeutic Intervention;Tissues;Training;transcriptome sequencing;treatment strategy;triple-negative invasive breast carcinoma;tumor;Tumor Angiogenesis;tumor growth;Tumor Promotion;Tumor-Derived;vascular bed;Vascular Endothelial Cell;Vascular Endothelium;Vascular System;Veins;Visualization;Work

PROJECT_TITLE: The Study of Jag1-Notch in the Extravasation of Triple Negative Breast Cancer Cells in Metastasis.


ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Bacterial infections remain a leading cause of death, a problem that is aggravated by the limited effectiveness of antibiotics for killing slow-growing and dormant bacteria, such as recurrent E. coli urinary tract infections. We propose to elucidate how bacteria can survive prolonged dormant metabolic states and how this affects pathogenesis and treatment. Identifying molecular mechanisms of adaptability and survival in slow growing bacteria may uncover new targets for novel antibiotics.

PI_NAMEs: BASAN, MARKUS THOMAS (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Affect;Antibiotic Resistance;antibiotic tolerance;Antibiotics;Bacteria;Bacterial Infections;Biology;Biophysics;Cause of Death;cell envelope;combat;Complex;cystic fibrosis patients;Data;Death Rate;Developed Countries;Effectiveness;Energy Metabolism;Escherichia coli;experience;Genes;Genetic;genetic resistance;Growth;insight;Laboratories;Membrane;Metabolic;Microbial Biofilms;Molecular;novel;Nutrient;Osmoregulation;Oxygen;Pathogenesis;pathogenic Escherichia coli;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiology;Positioning Attribute;Process;Proteomics;Pseudomonas aeruginosa infection;Recurrence;recurrent infection;Role;Tuberculosis;Urinary tract infection;Woman;wound healing

PROJECT_TITLE: Elucidating physiology of dormant bacteria to combat antibiotic persistence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Despite revolutionary advancement in immunotherapy and targeted therapy, the overall survival of metastatic prostate cancer patients remains limited. Tubulin inhibitors are first line chemotherapeutic agents for prostate cancer, but prolonged use of existing anti-tubulin drugs often results in drug resistance and neurotoxicities. We proposed in this grant to continue our productive efforts to develop a new generations of tubulin inhibitors that can overcome clinically important drug resistance problems in prostate cancer; completion of the proposed studies will provide the next generation of tubulin inhibitors as more efficacious therapy to treat metastatic prostate cancer and other types of cancers.

PI_NAMEs: LI, WEI  (contact);MILLER, DUANE D

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: ABCG2 gene;acquired drug resistance;Address;Affinity;Allergic;analog;Androgens;aqueous;Binding;Binding Sites;bisphosphonate;bone;Cancer Patient;cancer therapy;cancer type;Cell Line;chemotherapeutic agent;chemotherapy;Clinical;clinical candidate;clinical effect;clinical efficacy;Clinical Trials;Colchicine;Data;Daughter;design;Development;Disease;docetaxel;Dose;Dose Limiting;drug candidate;Drug Kinetics;Drug resistance;Drug usage;DU145;efficacious treatment;efficacy study;FDA approved;FOLH1 gene;Fracture;Frequencies;Funding;Future;Generations;Goals;Grant;Hematopoietic;Hybrids;Immunotherapy;improved;In Vitro;in vivo;in vivo Model;inhibitor;Lead;Length;Malignant neoplasm of prostate;Malignant Neoplasms;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Modeling;mortality;Neoplasm Metastasis;nerve damage;neurotoxicity;Neutropenia;next generation;novel therapeutics;Oral;overexpression;Pain;patient derived xenograft model;Patients;Peripheral Nervous System Diseases;Pharmaceutical Preparations;Phase II Clinical Trials;phase II trial;phase III trial;Productivity;Property;prostate cancer cell line;prostate cancer metastasis;prostate cancer model;Prostate Cancer therapy;Prostatic Neoplasms;pyrrolidin-3-yl-methanesulfonic acid;Quality of life;Resistance;resistance mechanism;Resolution;Roentgen Rays;scaffold;side effect;Site;Solubility;spinal cord compression;Structure;success;surfactant;targeted agent;targeted treatment;taxane;Therapeutic;Therapeutic Index;Toxic effect;triple-negative invasive breast carcinoma;Tubulin;tumor;X-Ray Crystallography;Xenograft Model

PROJECT_TITLE: Targeting the colchicine binding site in tubulin for cancer therapy

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Diabetes

ORG_CITY: LEBANON

ORG_NAME: CELDARA MEDICAL, LLC

ORG_STATE: NH

PHR: Project Narrative Here we propose to develop CM-TS1, a novel antibody directed at soluble and toxic misfolded conformations of human islet amyloid polypeptide (hlAPP) called protofibrils. These protofibrils have been demonstrated to cause the destruction of the insulin-producing pancreatic β cells and expedite disease progression in Type 2 diabetes mellitus (T2D), a chronic and progressive condition that affects 10 to 25% of the U,S. population and results in a patient population that continues to be underserved with current on-market therapies. The overarching goal of this Fast Track application is to validate CM-TS1's ability to preserve β cell function and ultimately delay disease progression using an industry standard in vivo proof-of-concept approach, and subsequently advance CM-TS1 into preclinical development for the treatment of T2D.

PI_NAMEs: MURAD, JOANA M (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Address;Affect;Affinity;American;Amyloid;Amyloid Fibrils;amyloid formation;Amyloidosis;analog;analytical method;Animal Model;Antigens;Apoptosis;Beta Cell;Binding;Binding Proteins;biophysical properties;Blood Glucose;cell bank;Cell Death Induction;cell injury;Cell Physiology;Cell Survival;Cells;cost;Dependence;Deposition;Development;Diabetes Mellitus;diabetic;diabetic patient;Disease;Disease Progression;Dose;Drug Kinetics;efficacy study;Engineering;Epidemic;Evaluation;Excision;Future;Gastroparesis;Glucagon;Glucose;glycemic control;Guidelines;Health;high risk;Hormones;Human;improved;In Vitro;in vivo;Individual;Industry Standard;Insulin;Insulin Resistance;insulin secretion;islet;islet amyloid polypeptide;Islets of Langerhans;Lead;manufacturability;Medical;Medication Management;meetings;Membrane;Molecular Chaperones;Molecular Conformation;Monoclonal Antibodies;monomer;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;novel therapeutics;nucleobindin;overexpression;Pancreas;pancreatic juice;Pathologic;Pathology;Patients;peptide hormone;Peptides;Peripheral;peripheral blood;Phase;Physicians;Physiological;Population;Pramlintide;Pre-Clinical Model;preclinical development;Prediabetes syndrome;preservation;prevent;Process;Production;Public Health;response;Rodent;Satiation;Schedule;Scientist;Specific qualifier value;Specificity;stable cell line;standard of care;Stress;Structure;success;Therapeutic;therapeutic development;Therapeutic Monoclonal Antibodies;Therapeutic Uses;Time;tool;Toxic effect;Transgenes;Transgenic Mice;Treatment Efficacy;United States

PROJECT_TITLE: Anti-hIAPP for the preservation of pancreatic function in Type 2 Diabetes