ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative Mosquito-borne diseases are a global concern that impact public health, tourism, and natural disaster recovery efforts. With no preventative vaccines or effective therapeutic option available for most mosquito-borne diseases, vector control efforts are the only combative option; however, these efforts are often limited by financial constraint and insecticide resistance concern. This proposed project aims to integrate cutting-edge mosquito collection traps, and novel remote sensing and machine learning workflows to guide local vector operations and direct abatement efforts in a cost-efficient manner.

PI_NAMEs: GUNTER, SARAH MURPHY;NOLAN, MELISSA SUZANNE (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Abate;Aedes;Algorithms;Aptitude;arboviral disease;Arbovirus Infections;Arboviruses;Area;Artificial Intelligence;atmospheric sciences;Bite;Breeding;Budgets;Cessation of life;Characteristics;chikungunya;Chikungunya virus;Cities;Climate;climate change;Clinical;Collection;combat;Comparative Study;Competence;Complex;Compost;cost;cost efficient;Culicidae;Data;data standards;Decision Making;Dengue;Dengue Virus;Detection;Development;Discipline;Disease;Disease Outbreaks;Ecology;Economics;Environment;Environmental Health;Environmental Impact;Epidemic;Evaluation;Event;Eye;Food;Gases;Geography;Gravid;Growth;Habitats;Health;Health Benefit;high risk;Household;Human;Human Bites;Image Analysis;Imagery;Impairment;improved;indexing;Individual;Industry;Infrastructure;innovation;Insecticide Resistance;Insecticides;Intervention;Lasers;Life;Location;Machine Learning;machine learning model;Manuals;Maps;meteorological data;Methods;metropolitan;Microclimate;Mosquito Control;Mosquito-borne infectious disease;Natural Disasters;Neighborhoods;Neurologic;next generation;novel;Oils;operation;Outcome;pathogen;Pattern;Persons;Pilot Projects;Population;predictive modeling;predictive signature;preference;preservation;Prevention;Preventive vaccine;Process;programs;prospective;Protocols documentation;Public Health;rapid detection;Reaction;Recovery;remote sensing;Reproducibility;Resolution;Resources;Risk;Robotics;scientific atmosphere;Seasons;Security;Sentinel;Side;Site;Solid;Sorting;spectrograph;Surveillance Methods;System;Techniques;Technology;Testing;therapeutically effective;Time;tool;Toy;transmission process;United States National Aeronautics and Space Administration;vector;vector control;Visualization;wasting;Weather;weather patterns;ZIKA;Zika Virus

PROJECT_TITLE: Next generation mosquito control through technology-driven trap development and artificial intelligence guided detection of mosquito breeding habitats

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE  During the last ten years, it has become apparent that deregulation or disruption of proteins residing at the Intercalated Disk (ICD), the unique membrane microdomain that mediates the mechanical and electrical coupling of cardiomyocytes, leads to cardiac defects and development of severe or lethal cardiomyopathies. The proposed studies will provide important and novel information about the modulation of a major component of the ICD, N-cadherin, via the enzymatic activity of the obscurin Ser/Thr kinase domain 1. Elucidating the molecular mechanisms that underlie cell-cell adhesion and communication in cardiac muscle during normalcy will allow us to understand how these are altered or compromised during congenital heart disease, and thus enable us to develop new, effective, and targeted therapies.

PI_NAMEs: KONTROGIANNI-KONSTANTOPOULOS, AIKATERINI  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Address;Adherens Junction;Adhesions;Affect;Affinity;Aging;Aortic Valve Stenosis;Arrhythmogenic Right Ventricular Dysplasia;Binding;Biochemical;Biological;Biological Assay;Calmodulin;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiomyopathies;Catalytic Domain;Cell Communication;Cell-Cell Adhesion;Classification;Communication;congenital heart abnormality;Coupling;Cytoplasmic Tail;Cytoskeletal Proteins;Development;Dilated Cardiomyopathy;Disease;Dominant-Negative Mutation;effective therapy;Electrophysiology (science);Family;Fibronectins;Gene Delivery;Genes;Health;Heart;heart defect;Heart Diseases;Heart failure;Human;Immunoglobulins;In Vitro;in vivo;Injections;Intercalated disc;Kinetics;Knock-in Mouse;Left ventricular non-compaction;Link;Mass Spectrum Analysis;Mechanics;Mediating;member;Membrane;Membrane Microdomains;Missense Mutation;Modeling;Molecular;Morphology;mouse model;Mus;Mutagenesis;Mutate;Mutation;Myocardium;Myosin Light Chain Kinase;N-Cadherin;next generation sequencing;Normalcy;novel;novel therapeutics;obscurin;overexpression;Pathogenesis;Pathogenicity;Patients;phosphoproteomics;Phosphorylation;Phosphotransferases;Physiological;Play;Pre-Clinical Model;Property;Protein Isoforms;Protein Truncation;Proteins;Role;Sarcolemma;Sequence Homology;Signal Transduction;Site;Striated Muscles;Structure;Surface Plasmon Resonance;Tachycardia;targeted treatment;therapy development;Time;Variant;Viral;Work;young adult

PROJECT_TITLE: Obscurin-kinase 1/N-cadherin: a new signaling axis in cardiac structure/function

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative Obesity is among the most common and costly disorders affecting Western society, yet underlying pathogenic mechanisms remain unclear. We propose that activation of brain microglial cells by high-fat diet consumption causes loss of key regulatory structures called perineuronal nets (PNNs), leading to disruption of the control system for body weight. Here, we will formally test this model by directly assessing the contributions of microglial activation and PNN loss to the development of obesity.

PI_NAMEs: SCHWARTZ, MICHAEL W;THALER, JOSHUA P (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;Acute;Affect;Aging;Appetite Stimulants;Area;blood glucose regulation;Body System;Body Weight;Brain;Chondroitin ABC Lyase;Chondroitin Sulfate C;Chondroitin Sulfate Proteoglycan;Chronic;Complement;Consumption;cost;Data;defined contribution;Development;Diet;diet-induced obesity;Disease;Eating;Electrophysiology (science);Excision;Extracellular Matrix;Fatty acid glycerol esters;feeding;Fiber;Functional disorder;glial activation;Gliosis;glucose tolerance;Goals;High Fat Diet;Homeostasis;Human;Hyaluronan;Hyperphagia;Hypothalamic structure;Impairment;improved;in vivo;Inflammatory;Inflammatory Response;Intake;Intervention;Kinetics;Laboratories;Link;Mediator;Metabolic;Microglia;Modeling;Mus;Nature;Neuronal Dysfunction;neuronal excitability;Neurons;neuropathology;novel;Obesity;obesity development;overexpression;Parvalbumins;Pathogenesis;Pathogenicity;Phagocytosis;Phenocopy;Phenotype;Photometry;Play;Predisposition;preservation;Property;rapid weight gain;Rattus;Reporting;Resources;Rodent;Role;Slice;Societies;Structure;Structure of nucleus infundibularis hypothalami;success;Synaptic plasticity;synergism;Testing;Vertebral column;Weight Gain;Weight maintenance regimen;Work

PROJECT_TITLE: Defining the contributions of hypothalamic microglia and perineuronal nets to obesity pathogenesis

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Modified Public Health Relevance Section Diabetes is a serious public health problem in the United States that affects more than 29 million people. Reduction in insulin secretion from pancreatic beta cells causes diabetes. The proposed project improves our fundamental knowledge of how beta cells secrete insulin to maintain blood glucose levels and aligns with the mission of NIH to find the treatment for Type 2 diabetes.

PI_NAMEs: BHATNAGAR, SUSHANT  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Address;Adult;Affect;Alpha Cell;Beta Cell;Binding;Binding Proteins;Blood Glucose;blood glucose regulation;Body Weight;Cell membrane;Cell Physiology;cell type;Chemosensitization;Co-Immunoprecipitations;comparison control;Competence;Complex;Coupled;Cues;D Cells;Data;Defect;Diabetes Mellitus;diet-induced obesity;Disease;Event;Exhibits;Exocytosis;experimental study;Functional disorder;Funding;glucagon-like peptide 1;Glucose;glucose tolerance;Goals;High Fat Diet;hormone regulation;Human;Immunofluorescence Immunologic;impaired glucose tolerance;Impairment;improved;inhibitor;Insulin;Insulin Antagonists;insulin granule;insulin secretion;insulin sensitivity;Investigation;islet;Islet Cell;knock-down;Knockout Mice;Knowledge;Link;Mediating;Membrane Proteins;Metabolic Clearance Rate;metabolic phenotype;Mission;Molecular;Molecular Target;Mus;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutritional;Obese Mice;Obesity;old mice;Outcome;Pathway interactions;Persons;Phase;Phosphorylation;Phosphorylation Site;Physiology;Plasma;Population;Post-Translational Protein Processing;Prediabetes syndrome;Predisposition;prevent;protein degradation;Proteins;Public Health;public health relevance;Published Comment;Reporting;response;Role;secretion process;Signal Pathway;Signal Transduction;SNAP receptor;soluble NSF attachment protein;Stimulus;Structure of beta Cell of islet;synaptotagmin;syntaxin;ubiquitin-protein ligase;United States;United States National Institutes of Health

PROJECT_TITLE: The role of Tomosyn-1 in regulating insulin secretion from pancreatic beta-cells

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH CAR-T cell therapy reprograms a patient’s own immune cells to identify and destroy tumors with precision, trans- lating to revolutionary new treatment paradigm for certain blood cancers. Unfortunately, CAR-T cell therapy is enormously expensive, (~$500,000) and has a slow manufacturing process and enormous regulatory hurdles for facilities that manufacture CAR-T cells. We will develop a technology to manufacture CAR-T cells within a patient's own body to dramatically cut costs and increase patient access.

PI_NAMEs: BRUDNO, YEVGENY  (contact)

PROGRAM_OFFICER_NAME: SALOMON, RACHELLE

PROJECT_TERMS: 3-Dimensional;Adopted;Alginates;Allogenic;Architecture;Autologous;B lymphoid malignancy;Biocompatible Materials;biomaterial compatibility;bioscaffold;Blood;CAR T cell therapy;CD28 gene;CD3 Antigens;Cell Count;Cell Differentiation process;Cell Physiology;Cells;Cellular biology;cellular transduction;Chemicals;chemokine;chimeric antigen receptor T cells;Circulation;Clinical;clinically relevant;cost;crosslink;CXCL10 gene;Data;design;Devices;Disease;Drug Delivery Systems;Encapsulated;engineered T cells;Engineering;Engraftment;Ensure;fighting;Generations;Goals;graft vs host disease;Hematopoietic Neoplasms;high reward;high risk;Immune;immunogenicity;Implant;improved;In Situ;In Vitro;in vivo;innovation;Interleukin-2;Interleukins;Ions;Kinetics;leukemia/lymphoma;Liquid substance;Longevity;Lymphocyte;Malignant Neoplasms;manufacture;manufacturing facility;manufacturing process;Measures;mechanical properties;Mediating;Medical;Methods;Modeling;mouse model;multidisciplinary;particle;patient population;Patients;Phenotype;Physiological;Porosity;prevent;procedure cost;Procedures;Process;Production;programs;Public Health;Publishing;recruit;Recurrent tumor;Resistance;response;Retroviral Vector;scaffold;Signal Transduction;Solid;Solid Neoplasm;Specialist;Stream;Stress Tests;success;System;T-Cell Activation;T-Lymphocyte;Technology;Therapeutic;Time;Translating;tumor;Viral;Viral Vector;Work

PROJECT_TITLE: Biomaterial Scaffolds for In Vivo CAR T Cell Manufacture

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: NEWARK

ORG_NAME: INSITEHUB LLC

ORG_STATE: DE

PHR: Project Narrative The DE iRED team will develop a rigorous and engaging online curriculum to support the goals and bridge the gap of sufficient training and knowledge for innovators through a high-availability, scalable, on-demand platform. This will result in better education and increase the number of biomedical entrepreneurs, increase the number of biomedical startups developing market-driven technologies applying for SBIR/STTR and accessing existing ecosystem resources. The end result will provide increased knowledge, more high-tech small business startups and advances in commercialization of the developed medical products.

PI_NAMEs: KORLEY, JULIUS N.;ROYER, JOHN  (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Address;Area;Award;Basic Science;Biological Models;Biomedical Research;Biotechnology;Businesses;Cessation of life;Chemistry;cohort;commercialization;Critical Pathways;Data;Delaware;Development;Disclosure;Ecosystem;Education;Educational Curriculum;Engineering;Ensure;Entrepreneurship;Evaluation;experience;Exposure to;Failure;Funding;Goals;ideation;improved;innovation;innovative technologies;insight;Institution;Intervention;Interview;invention;Knowledge;Learning;Legal patent;Licensing;Marketing;Measures;Medical;Medical Technology;Mentors;Methodology;Modeling;Monitor;National Institute of General Medical Sciences;new technology;online course;outreach;Participant;Pathway interactions;Patients;Performance;Pharmacologic Substance;Phase;Phase Transition;Price;Private Sector;Process;product development;Program Evaluation;programs;prototype;Readiness;Request for Proposals;research study;Resources;Science;Small Business Innovation Research Grant;Small Business Technology Transfer Research;success;Technology;technology development;Technology Transfer;Testing;Training;Translating;trend;Universities;validation studies;Voice;Work

PROJECT_TITLE: Increasing IDeA state Biomedical Entrepreneurship via Ecosystem, Enterprises & Experts


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Brain Disorders;Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Neurosciences;Pain Research;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative This project will investigate pain phenotypes by coalescing data between the BACPAC and REJOIN Consortia.

PI_NAMEs: ALLEN, KYLE D (contact);ALMARZA, ALEJANDRO JOSE;CRUZ-ALMEIDA, YENISEL

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: addiction;Anatomy;Back;Back Pain;Biological Markers;Blood;chronic musculoskeletal pain;chronic painful condition;Clinical;clinical pain;Collection;Comprehension;Data;data integration;Evaluation;experience;Functional impairment;healing;Health;human study;Intervention;Joints;Knee joint;Location;Musculoskeletal Pain;nerve supply;opioid abuse;Pain;Pain management;pain perception;pain reduction;Pathologic;patient population;Patients;Pattern;Phenotype;phenotypic data;Principal Investigator;programs;psychological distress;Quality of life;Research;Research Methodology;Research Project Grants;Sampling;Site;Temporomandibular Joint;United States National Institutes of Health

PROJECT_TITLE: Comparing pain phenotypes across lower back, knee, and TMJ


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Rural, Latina farmworkers experience significant disparities in both maternal and overall cardiovascular disease (CVD) morbidity and mortality, with greater CVD risk factors than their urban, white, and male counterparts – disparities driven in part by social determinants of health (SDOH). With the rapid growth of Latinas in the U.S. farming workforce, it is imperative to implement and evaluate strategies to reduce CVD risk, premature CVD including in the perinatal period, and overall CVD morbidity and mortality. We will conduct a hybrid type 1 effectiveness-implementation trial to evaluate the effectiveness and implementation of an adapted peer support, community health worker/promotora-led intervention for rural, migrant, reproductive- aged Latina farmworker women.

PI_NAMEs: FERRANTI, ERIN POE (contact);KELLY, URSULA ANN

PROGRAM_OFFICER_NAME: AKUBU-ODERO, MAUREEN KALAMBU

PROJECT_TERMS: Acceleration;Address;Age;aged;American Heart Association;Anxiety;Automobile Driving;Behavior;Behavioral;Biomedical Research;Black race;Cardiac health;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Caring;Cause of Death;Chronic stress;Clinical;Communities;community collaboration;Community Health Aides;community partnership;Conceptions;Disparate;disparities in women;Disparity;Economics;effective intervention;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Equity;Ethnic Origin;evidence base;Evidence based intervention;experience;Family;Family health status;Farm;farm worker;Funding;Gender;Geography;Goals;Health;health assessment;health care availability;health disparity;Health education;health equity;Health Food;high risk;high risk population;High Risk Woman;Housing;Hybrids;implementation evaluation;implementation facilitators;implementation outcomes;improved;Inequity;innovation;Intervention;Latina;Latina Population;Length;lens;Life;life span;literacy;Loneliness;Low income;Maintenance;male;marginalized population;maternal morbidity;Maternal Mortality;Mediating;Mediation;member;Mental Depression;Mental Health Services;Methods;Migrant;Morbidity - disease rate;mortality;Occupational;Outcome;Pathway interactions;peer support;perinatal period;physical conditioning;Population;post-traumatic stress;Pregnancy;premature;Prenatal care;preventive intervention;programs;psychologic;psychological distress;psychological symptom;rapid growth;Reporting;reproductive;Research;Resources;Risk;Risk Factors;Role;Rural;Rural Health;Safety;Science;social;Social Behavior;social health determinants;Social isolation;Social support;Social Well-Being;Stress;Support Groups;Testing;Training;Transportation;Trauma;trauma exposure;Woman;Work;Workplace

PROJECT_TITLE: Hermanas de Corazón: A Community Health Worker Initiative for improving Heart Health in Migrant Latina Farmworker Women

STUDY_SECTION_NAME: Special Emphasis Panel[ZNR1 REV-M (44)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: The interaction between prefrontal and visual cortical areas is critical for many cognitive functions including attention and working memory. This proposal investigates the role of phase coding in visual cortex, along with its modulation by prefrontal activity during working memory, and the ability of a similar coding mechanism to expand the information capacity of the visual system during eye movements. Understanding the role of phase coding during working memory and eye movements will provide a necessary comparison point for neurological disorders involving impaired prefrontal-sensory interactions, including schizophrenia, Alzheimer’s disease, attention deficit hyperactivity disorder, and autism spectrum disorders.

PI_NAMEs: NOUDOOST, BEHRAD  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Action Potentials;Address;Alzheimer's Disease;Area;area MT;area V4;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;behavior influence;Brain;Code;Cognitive;cognitive function;Communication;Coupled;Coupling;design;Electrodes;Event;experimental study;extrastriate;extrastriate visual cortex;Eye Movements;Frequencies;frontal eye fields;Funding;Goals;Impairment;Link;Maintenance;Measures;Mediating;Memory;Nature;Nervous System Disorder;neural;neural correlate;Neurons;nonhuman primate;Pattern;Periodicity;pharmacologic;Phase;Play;Population;Prefrontal Cortex;Property;rate of change;receptive field;recruit;Reporting;Research;response;Role;Saccades;Schizophrenia;Sensory;Short-Term Memory;Signal Transduction;Source;Stimulus;Testing;theories;Time;Visual;Visual Cortex;Visual Fields;visual information;Visual Perception;Visual System

PROJECT_TITLE: Prefrontal contributions to phase-dependent representation of visual information

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative: Responding to the pressing need to enhance digital literacy as a means to improve access to healthcare resources for rural populations, and in alignment with NINR’s call for Strategies to Improve Health Outcomes and Advance Health Equity in Rural Populations (RFA-NR-24-005), we developed CONNECT, a web-based tool designed to enhance digital literacy and access to cancer-related emotional distress and anxiety resources for rural older cancer survivors (ROCS). Building upon the positive feedback from our usability pilot and the Designing for Dissemination logic model, the proposed study seeks to adapt CONNECT to include functions recommended from our usability pilot and assess its efficacy and implementation in improving levels of cancer- related distress and digital engagement for ROCS compared to an enhanced standard care arm in a 12-month RCT. Successful completion of our aims will yield: 1) multi-level strategies enhancing healthcare delivery and access, fostering health equity in rural populations by improving digital literacy; 2) design strategies supporting the potential sustainability of digital tool development for marginalized populations; and 3) pertinent data to facilitate the scaled implementation of CONNECT in a future implementation-effectiveness hybrid trial.

PI_NAMEs: LEWIS, MARQUITA W. (contact)

PROJECT_TERMS: 2 arm randomized control trial;Acceleration;Address;Adoption;age related;Anxiety;Area;arm;cancer diagnosis;Cancer Survivor;cancer therapy;Caregivers;Caring;clinical care;Communication;Communities;community setting;COVID-19;Critical Care;Data;design;digital;digital health;digital mental health;digital platform;digital tool;Distress;Education;education access;Educational Materials;Educational workshop;Effectiveness;effectiveness/implementation trial;efficacy evaluation;efficacy testing;emotional distress;Enrollment;Equity;experience;Face;Feedback;Fostering;Funding;Future;future implementation;Goals;group intervention;Health;health care availability;health care delivery;health care quality;health equity;health inequalities;Health Professional;Health Resources;Health Services Accessibility;Healthcare;Healthcare Systems;human old age (65+);implementation science;Improve Access;improved;Individual;Inequity;informal caregiver;informant;Infrastructure;innovation;insight;Intervention;Interview;Investments;Knowledge;Learning;literacy;Literature;Logic;Malignant Neoplasms;marginalized population;Medical;Medical Care Costs;member;Mental Health;Mental Health Services;Modeling;novel;older adult;Online Systems;Outcome;Participant;Patient Outcomes Assessments;Patients;poor health outcome;Population;Positioning Attribute;primary outcome;Printing;Process;Published Comment;Randomized;Reader;Recommendation;Reporting;Research;Resources;Rural;rural area;Rural Community;rural counties;Rural Health;rural health clinic;rural health disparities;Rural health equity;rural healthcare;Rural Hospitals;rural patients;Rural Population;rurality;scale up;Screening Result;Site;social health determinants;Social support;standard care;standard of care;Stress;survivorship;telehealth;Time;tool;tool development;Training;Travel;treatment as usual;United States National Institutes of Health;uptake;usability;user centered design;Visit;Visual impairment;web-based tool;Work

PROJECT_TITLE: Designing for sustainability: Co-designing and testing the efficacy of a web-based toolkit to improve cancer-related emotional distress and anxiety for rural older cancer survivors


NIH_SPENDING_CATS: Biotechnology;Genetics;Microbiome

ORG_CITY: MADISON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PARENT AWARD R35GM148385 PROJECT NARRATIVE Animal-coloning bacteria transition from an environmental lifestyle to the host-associated state, in which individual bacterial cells coordinate functions to act as a group. Using a model system that allows for interrogation of bacteria within the animal host, this project addresses how the host and microbes exchange and interpret molecular signals, leading to group versus solitary behaviors of the colonizing microbes. This project has ramifications for therapeutic interventions to establish beneficial microbes (e.g. probiotics) and to understand and interfere with colonization by pathogenic microbes.

PI_NAMEs: MANDEL, MARK J (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Address;Animals;antimicrobial;Bacteria;Bacterial Genes;Behavior;beneficial microorganism;Biological Models;Cells;Chemicals;Communication;Environment;Exclusion;genetic analysis;genetic approach;genetic manipulation;Goals;host colonization;host-microbe interactions;Hour;Image;Immune;Individual;Infection;Investigation;Laboratories;Laboratory Study;Life Style;Ligands;Light;Microbe;Microbial Biofilms;microbiome;Modeling;Molecular;novel;Organ;parent project;pathogenic microbe;Play;Probiotics;Process;protein function;Proteins;Reproducibility;RNA-Binding Proteins;Route;Seawater;Signal Pathway;Signal Transduction;Site;small molecule;Specificity;Squid;success;symbiont;System;Therapeutic Intervention;transmission process;V. fischeri-squid system;Vibrio fischeri;Work

PROJECT_TITLE: Genetic analysis of beneficial bacterial colonization


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: The increased expression of angiotensin converting enzyme (ACE) enhances the immune function of macrophages and neutrophils by altering their metabolism and increasing cell production of ATP. This proposal is to investigate exactly how ACE modifies myeloid cell metabolism to learn how to increase myeloid cell function in treating human infection, malignancy and other diseases.

PI_NAMEs: BERNSTEIN, KENNETH E (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: ACE2;Acute;adaptive immune response;Address;Affect;Angiotensin II;Angiotensin-Converting Enzyme Inhibitors;Angiotensins;Antibacterial Response;autocrine;Biochemical;Blood Pressure;Cardiovascular system;Cell Physiology;Cell Respiration;Cells;Cellular Metabolic Process;Chemicals;Chronic;Chronic Disease;Clinical;Data;Disease;Effectiveness;enzyme activity;Enzyme Induction;enzyme mechanism;enzyme substrate;Enzymes;fighting;Genetic;Goals;Human;Immune;immune function;Immune response;Infection;Inflammatory;Innate Immune Response;Knock-out;Learning;Link;lipid metabolism;Lipids;Macrophage;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Medical Research;Metabolic;Metabolism;Mus;Myelogenous;Myeloid Cells;neutrophil;novel;overexpression;Oxidative Phosphorylation;Paper;paracrine;Peptides;Peptidyl-Dipeptidase A;Phenotype;PPAR alpha;Process;Production;Proteins;Ramipril;response;Role;Solid;Superoxides;transcription factor;tumor;volunteer

PROJECT_TITLE: ACE and myeloid cell metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-D(90)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: Project Narrative Mild cognitive impairment is a defining feature of early Alzheimer’s disease, but it is also associated with many other conditions such as HIV-infection, where the prevalence rate is much higher than the general population. Despite this, there is a fundamental lack of scientific knowledge regarding the shared and distinct mechanisms underlying cognitive impairment in people with HIV, early Alzheimer’s disease, and normal aging adults. The current project uses a state-of-the-art dynamic functional mapping approach to identify the specific brain circuits and neural processes that uniquely contribute to cognitive impairment in these different populations.

PI_NAMEs: WILSON, TONY W (contact)

PROGRAM_OFFICER_NAME: SRINIVASAN, SUDHA

PROJECT_TERMS: Adult;Affect;aging brain;aging related disease;Alzheimer's Disease;American;Amyloid;Amyloid deposition;Animals;Architecture;Attention;Biological Markers;Brain;Brain Diseases;brain dysfunction;Brain imaging;Brain Pathology;Brain region;cerebral hemodynamics;Code;Cognitive;Cognitive deficits;cognitive function;cognitive performance;cognitive process;cognitive system;cognitive task;cognitive testing;Collection;Data;Deposition;Diabetes Mellitus;Etiology;Exhibits;experience;Faculty;Follow-Up Studies;Frequencies;Functional Magnetic Resonance Imaging;General Population;healthy aging;HIV;HIV Infections;HIV-associated neurocognitive disorder;Human;Image;Impaired cognition;Impairment;information processing;innovation;insight;instrumentation;Knowledge;Literature;Magnetoencephalography;Maps;Matched Group;Measures;Methods;mild cognitive impairment;multimodal neuroimaging;multimodality;Mus;neural;neural circuit;neuroAIDS;neuroimaging;Neurology;Neurons;neuropathology;neurophysiology;Neuropsychology;next generation;normal aging;novel;Parkinson Disease;Participant;Pathologic;pathological aging;Pathology;patient population;Patients;Performance;Persons;Phase;Physiology;Play;Population;Positron-Emission Tomography;Prevalence;prevent;Probability;Process;Publishing;Reporting;Resolution;response;Rest;Role;Series;spatiotemporal;Specificity;System;Task Performances;temporal measurement;Time;tool;Visual;Visual attention;Visual Perception;Visuospatial;Work

PROJECT_TITLE: Dynamic Functional Mapping of Alzheimer's Spectrum and HIV-related Brain Dysfunction

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Microbiome;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative As our population ages, the incidence of Alzheimer's disease increases adding economic and social stress. Here, we seek to dissect how consumption of a sugar-loaded diet alters the microbiome and contributes to the onset and severity of Alzheimer's disease with a long-term goal of using diet as an intervention for Alzheimer's disease.

PI_NAMEs: TISSENBAUM, HEIDI A (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: abeta accumulation;Address;Advanced Glycosylation End Products;Affect;Age;age related;Aging;Alzheimer's Disease;Alzheimer's disease patient;American;American diet;Amino Acids;Amyloid beta-42;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Animal Diseases;Animals;Bacteria;Brain;Buffers;Caenorhabditis elegans;Circulation;constitutive expression;Consumption;Data;Diabetes Mellitus;Diet;dietary;Dietary Sugars;Economics;Environment;Escherichia coli;Food;gastrointestinal system;Genes;Genetic;Glucose;glycation;Goals;Grant;gut microbiota;Health;Health Care Costs;healthspan;Human;Immune;Immune signaling;Incidence;inducible gene expression;Inflammation;insight;Intervention;life span;Link;Lipids;Metabolism;Microbe;microbiome;microbiome alteration;microbiota;Movement;Muscle;mutant;Neurons;Orthologous Gene;Oxidative Stress;Paralysed;Pathogenicity;Pathway interactions;Peptides;Persons;Population;presenilin;Process;promoter;Proteins;Publishing;Regulation;Series;Severities;Signal Pathway;Silver;social stress;Source;Stress;stress management;Structure;sugar;System;Testing;Tissues;tool;Transgenic Animals;Transgenic Organisms;Tsunami

PROJECT_TITLE: Dissecting connections between diet, the microbiome and Alzheimers disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Z(55)]


ORG_CITY: TENAFLY

ORG_NAME: ARMA BIO, INC.

ORG_STATE: NJ

PHR: Narrative Prostate cancer is the second most commonly diagnosed cancer in men in the U.S. and is responsible for about 34,000 deaths and an economic toll of $13 billion each year. To treat men whose cancer has advanced to castration-resistant prostate cancer, Arma Bio is developing dual inhibitors of the full-length androgen receptor (AR-fl) and AR-V7, the most prevalent splice variant in men with this cancer. A dual inhibitor that can overcome drug resistance will offer a much-needed therapeutic option for men with castration-resistant prostate cancer, ultimately improving clinical outcomes.

PI_NAMEs: AU, CHEUK MAN CHERIE  (contact)

PROGRAM_OFFICER_NAME: REGMI, SAROJ GOPAL

PROJECT_TERMS: advanced prostate cancer;Androgen Antagonists;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;biomarker development;cancer diagnosis;Cancer Etiology;Cell Nucleus;Cessation of life;Clinical;clinical biomarkers;Data;deprivation;Development;Diagnosis;Disease;Drug Kinetics;Drug resistance;Economic Burden;Economics;efficacy evaluation;enzalutamide;Foundations;Goals;Growth;improved;in vivo;Incidence;inhibitor;Lead;lead candidate;Length;Malignant neoplasm of prostate;Malignant Neoplasms;manufacture;Marketing;Mediating;men;Metastatic Prostate Cancer;Modeling;Neoplasm Metastasis;Outcome;patient derived xenograft model;Patients;Pharmaceutical Chemistry;pharmacologic;prevent;Receptor Signaling;RNA Splicing;Signal Transduction;small molecule therapeutics;survival outcome;synergism;Therapeutic;therapeutic target;Toxic effect;Toxicology;Variant;Work;Xenograft procedure

PROJECT_TITLE: Development of small molecule therapeutics targeting AR-V7 for prostate cancer


ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

PHR: NARRATIVE The proposed research is relevant to public health because it investigates the immune mechanisms contributing to the transition from sub-clinical autoimmunity to clinical autoimmune disease, focusing on this transition in individuals at-risk for type 1 diabetes, rheumatoid arthritis and systemic lupus erythematosus.

PI_NAMEs: BUCKNER, JANE HOYT (contact);LONG, S ALICE

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Administrative Supplement;Autoantibodies;Autoimmune Diseases;Autoimmunity;Biological Markers;Clinical;clinical diagnosis;Clinical Trials;Data Analyses;data integration;Data Set;Disease;Ensure;high risk;Hydroxychloroquine;Immune;Individual;Insulin-Dependent Diabetes Mellitus;Measures;parent grant;Patients;placebo group;Placebos;prevent;Prevention;Prevention trial;protein expression;Proteome;Proteomics;Public Health;Research;Research Personnel;Rheumatoid Arthritis;Risk;Running;Sampling;Serum;Serum Proteins;specific biomarkers;Systemic Lupus Erythematosus;T-Lymphocyte;Testing;treatment arm

PROJECT_TITLE: Proteomic analysis of hydroxychloroquine prevention trials in T1D, RA and SLE


NIH_SPENDING_CATS: Biotechnology;Genetics;Kidney Disease

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed research is relevant to NIH’s mission since we want to identify a new therapeutic option for patients with autosomal dominant tubulo-interstitial kidney disease caused by Uromodulin mutations (ADTKD-UMOD). This condition is caused by heterozygous mutations in Uromodulin, which result in a misfolded protein, Uromodulin accumulation in the endoplasmic reticulum, apoptosis, renal fibrosis, and subsequently renal failure. We have been developing a cell cultured-based high throughput assay to identify compounds, which enhance mutant Uromodulin protein secretion in ADTKD-UMOD patients and thereby improve outcome of chronic and end-stage kidney disease in ADTKD-UMOD.

PI_NAMEs: WOLF, MATTHIAS TILMANN FLORIAN (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Acceleration;Affect;analog;Apoptosis;assay development;autosome;Biochemistry;Biological Assay;Calcium Channel;candidate identification;Canis familiaris;CASP3 gene;Cell Culture Techniques;Cell Line;Cell secretion;Cells;Characteristics;Chemicals;Chemistry;Chronic;Chronic Kidney Failure;Complement;Core Facility;counterscreen;Data;Defect;density;Dialysis procedure;Disease;disulfide bond;Disulfides;drug-like compound;Embryo;End stage renal failure;Endoplasmic Reticulum;Enzyme-Linked Immunosorbent Assay;Exclusion;experimental study;Fibrosis;Functional disorder;Future;Genetic;Goals;Heterozygote;high throughput screening;Human;Human Cell Line;Impairment;improved;improved outcome;in vivo;Inflammation;innovation;interstitial;Kidney;kidney cell;Kidney Diseases;Kidney Failure;kidney fibrosis;Kidney Transplantation;Lead;Libraries;Limb structure;Luciferases;MDCK cell;Measures;Metabolism;misfolded protein;Mission;Modality;Modeling;Molecular;molecular pathology;Molecular Target;Monitor;mouse model;Mus;mutant;Mutation;novel;novel therapeutics;patch clamp;Pathway interactions;Patients;Persons;pharmacologic;Pharmacology;Phenotype;Plasmids;Polycystic Kidney Diseases;pre-clinical;prevent;Primary Cell Cultures;Protein Secretion;protein transport;Proteins;Reporter;Research;scaffold;screening;small molecule libraries;Solubility;stable cell line;Structure-Activity Relationship;Supportive care;Testing;Therapeutic;Thick;tool;Toxic effect;trafficking;Transfection;translational impact;Tubular formation;UMOD gene;United States National Institutes of Health;Up-Regulation

PROJECT_TITLE: Assay development and optimization for a high throughput screen to detect compounds increasing secretion of C150S mutant Uromodulin

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-F(55)R]


NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Pediatric;Prevention;Social Determinants of Health

PHR: Contact PD/PI: Jackson, Daniel J. PROJECT NARRATIVE Asthma disproportionately affects children in urban communities in the United States and imposes a great personal and health care burden. Despite treatment advances, a significant proportion of patients do not achieve disease control and continue to have high levels of morbidity and currently no intervention has proven to either prevent or cure this disease. By identifying and addressing these unmet needs in this application, we propose to improve current asthma care in urban children, pursue disease modification, and ultimately develop effective strategies to prevent asthma.

PI_NAMEs: GERN, JAMES E.;JACKSON, DANIEL J (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Address;Administrative Supplement;Affect;Allergens;Allergic;Asthma;Biological Response Modifier Therapy;Birth;Blood;Blood specimen;Caring;Child;Childhood;Childhood Asthma;Clinical Trials;cohort;Data;data integration;Disease;disorder control;DNA;Environment;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;Experimental Designs;Exposure to;Factor Analysis;gene environment interaction;Genes;Genetic;genetic risk factor;Genetic study;Genetic Variation;genome sequencing;genome wide association study;Genotype;Health;healthcare burden;Hispanic;Hypersensitivity;IL4 gene;Immune response;Impairment;improved;inner city;Interferon Type II;Interleukin-13;Intervention;Leadership;Link;Mediating;Methylation;microbial;Modification;Morbidity - disease rate;Nasal Epithelium;Nose;novel;omalizumab;Outcome;Participant;Patients;Pattern;Phenotype;pollutant;polygenic risk score;Population;prevent;Publications;Research Design;respiratory;response;Role;Sampling;Self Care;Severities;Severity of illness;Site;Sputum;STAT3 gene;treatment response;TSLP gene;United States;urban children;Urban Community;urban setting;whole genome

PROJECT_TITLE: Childhood Asthma in Urban Settings Leadership Center Administrative Supplement for Genotyping Yr4


ORG_DEPT: SURGERY

PHR: Project Narrative Lung transplantation is an established therapy for patients with end stage pulmonary failure, yet survival rates after lung transplantation lag behind those observed after transplantation of other solid organs (SOT). Unlike other SOTs where the initiation of rejection depends on cell trafficking to graft-draining lymphoid organs, in the lung, lymphocyte priming occurs in the lung graft itself. Utilizing this knowledge, we will investigate the efficacy of bi-functional nanoagents capable of preventing immune cell infiltration and priming while concomitantly eliciting immunosuppression, with the overall goal of inducing graft tolerance.

PI_NAMEs: ATKINSON, CARL  (contact);MCCARTHY, JASON R.

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: allograft rejection;Allografting;Binding;Biological;Biological Assay;Biological Availability;Biology;Brain Death;Cardiovascular system;Cell Adhesion;Cell Adhesion Molecules;cell type;Cells;chemokine;Complex;cytokine;Data;delivery vehicle;design;Development;Dose;Drug Delivery Systems;Endothelial Cells;Endothelium;Equilibrium;Event;experience;Flow Cytometry;Formulation;FRAP1 gene;Goals;Graft Rejection;Graft Tolerance;Hand;Harvest;Immune;immune cell infiltrate;Immune response;Immunosuppression;Immunosuppressive Agents;improved;In Vitro;Infiltration;Inflammatory;Injury;insight;Intercellular adhesion molecule 1;Investigation;Knowledge;Libraries;Ligands;Lung;lung allograft;Lung Diseases;lung failure;lung injury;Lung Transplantation;Lymphocyte;lymphoid organ;Malignant Neoplasms;Modeling;Morbidity - disease rate;Mus;nano;nanoparticulate;new therapeutic target;novel;novel strategies;Organ;Organ Transplantation;Outcome;Pathway interactions;Patients;peptide drug;Peptides;prevent;Prevention;Prevention approach;Procedures;Property;receptor;Regulatory T-Lymphocyte;renal damage;Reperfusion Injury;response;Role;side effect;Signal Transduction;Sirolimus;Solid;Survival Rate;T-Lymphocyte;targeted delivery;Testing;Therapeutic;Therapeutic immunosuppression;tool;trafficking;Transgenic Mice;Transplantation;Up-Regulation;Validation;Vascular Cell Adhesion Molecule-1;Vascular Endothelium

PROJECT_TITLE: Targeted delivery of immunosuppressive agents to the graft endothelium forthe prevention of rejection in lung transplantation


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The California National Primate Research Center is an established national resource that has as a primary mission to improve human health and quality of life through support of exceptional nonhuman primate research programs that advance knowledge of the causes, preventions, treatments, and cures of debilitating diseases. This mission is pursued through robust on-site research programs, facilities, and expertise that serve the greater biomedical research community; this supplemental request is to address critical space needs for HIV/AIDS related research.

PI_NAMEs: ATKINSON, SIMON J. (contact)

PROGRAM_OFFICER_NAME: BUHRING, BETTINA D

PROJECT_TERMS: Address;Administrative Supplement;Age;Alzheimer's Disease;animal care;Animals;Appointment;Area;base;Behavior;Biomedical Research;California;career;Caring;Collaborations;college;Communicable Diseases;Communities;Critical Care;Dedications;Development;Disease;Ensure;Environment;fighting;Fostering;Funding;Goals;Grant;Growth;Health;high standard;HIV;HIV therapy;HIV/AIDS;Human;human disease;improved;Infrastructure;Knowledge;life span;Medical;Mentors;Mission;Modeling;Neurosciences;next generation;nonhuman primate;novel therapeutics;outreach;parent project;Prevention;Primates;programs;psychologic;Quality of life;recruit;Regenerative Medicine;Reproductive Sciences;Research;research and development;Research Design;Research Personnel;Research Priority;Research Support;Research Training;Resources;responsible research conduct;Role;Schools;Science;Scientist;Services;Site;technology/technique;tool;Training;translational scientist;United States National Institutes of Health;Universities;Vaccines;Veterinarians;Vision;ZIKA


NIH_SPENDING_CATS: Arthritis;Bioengineering;Biomedical Imaging;Clinical Research;Hematology;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE The goal of this study is to optimize and validate a series of 3D Ultrashort Echo Time (UTE) MRI sequences with TEs ~100 times shorter than those of clinical sequences for comprehensive evaluation of joints with hemophilic arthropathy (HA) through assessment of hemosiderin, cartilage, and the osteochondral junction. We will first optimize a series of UTE MRI techniques in phantoms and human patellar samples, then validate them in ex vivo tissues from hemophilia patients following total knee arthroplasty (n=10) and from normal cadaveric human knee joints (n=10). Finally, we will apply the optimized 3D UTE and clinical MRI techniques in three groups of hemophilia patients with mild (n=20), moderate (n=20), and severe (n=20) HA at two time points (baseline and 12 months) and in one group of age-matched healthy volunteers (n=20) once, to evaluate the outcomes of prophylaxis by correlating cross-sectional and longitudinal UTE and clinical MRI measures with Hemophilia Joint Health Scores (HJHSs), Pettersson radiograph scores, and other self-reported outcomes.

PI_NAMEs: JANG, HYUNGSEOK  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: 3-Dimensional;Achievement;Age;age group;Area;articular cartilage;Biochemistry;Biological Markers;Biomechanics;Blood Coagulation Disorders;Blood Coagulation Factor;Cadaver;Cartilage;Clinical;Collagen;contrast imaging;Control Groups;cost;Cyst;Data;density;Deposition;Deterioration;Diagnosis;Disabling;Disease Management;Disease Progression;Early Diagnosis;Etiology;Evaluation;Factor IX;Factor VIII;Fatty acid glycerol esters;Goals;Health;healthy volunteer;Hemophilia A;Hemophilic Arthritis;Hemorrhage;Hemosiderin;Histopathology;Human;Image;Imaging Techniques;in vivo;Iron;joint destruction;Joints;Knee joint;knee replacement arthroplasty;Lesion;Ligaments;Link;Longitudinal Studies;Magic;Magnetic Resonance Imaging;Magnetism;Maps;Measures;Meniscus structure of joint;Modeling;Monitor;Morphology;non-invasive imaging;Normal tissue morphology;osteochondral tissue;Outcome;Patient Self-Report;Patients;precision medicine;Predisposition;prevent;prophylactic;Prophylactic treatment;Proteoglycan;Quantitative Evaluations;Recovery;Recurrence;Relaxation;Resolution;Sampling;Scanning;Series;Signal Transduction;Speed;subchondral bone;Synovial Membrane;Synovitis;Techniques;Tendon structure;Time;Tissues;Treatment Cost;treatment planning;ultrasound;validation studies

PROJECT_TITLE: Ultrashort Echo Time Magnetic Resonance Imaging of Hemophilic Arthropathy

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Patient Safety;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PI_NAMEs: FOUTS, TIMOTHY  (contact)

PROJECT_TERMS: Adenoviruses;Clinical;Contracts;Development;Documentation;Feasibility Studies;flexibility;Formulation;Generations;Good Manufacturing Process;HIV-1 vaccine;Investigational Drugs;Investigator-Initiated Research;manufacture;mosaic;National Institute of Allergy and Infectious Disease;Pan Genus;Pharmaceutical Preparations;Phase;preclinical development;Preclinical Testing;Production;programs;Reagent;Recombinants;research clinical testing;research study;safety testing;scale up;stability testing;T-Lymphocyte;Technology Transfer;Testing;Vaccines

PROJECT_TITLE: Production of a Chimpanzee Adenovirus HIV-1 Vaccine


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Given that a substantial and increasing number of Veterans are using cannabis, it is essential for the VHA to understand how use is related to health, functioning, and service utilization outcomes among patients. Findings from the proposed study will have important implications for VHA patients, providers, and policymakers, including the better understanding of potential negative consequences associated with use among Veterans, the identification of patients for whom additional services may be indicated to address their cannabis use, and informing VHA clinical practice guidelines regarding cannabis use.

PI_NAMEs: BLOW, FREDERIC C;BLOW, FREDERIC C (contact)

PROJECT_TERMS: Address;Age;Awareness;Cannabis;cannabis use behavior;Certification;chronic pain;chronic pain management;Chronic Post Traumatic Stress Disorder;Classification;Clinical Practice Guideline;cohort;comparison group;Data;District of Columbia;follow-up;Health;health record;illicit drug use;Individual;innovation;Intervention;Interview;Laws;Legal;Link;marijuana use;marijuana use disorder;Medical;Medical center;Medical Marijuana;Mental disorders;Mental Health;Methods;Michigan;military service;Monitor;Nature;Opioid;Outcome;Pain;patient population;Patients;Pattern;Pharmaceutical Preparations;Policies;Policy Maker;Population;Post-Traumatic Stress Disorders;Primary Care;primary care patient;primary care visit;Provider;Qualifying;Reporting;Research;Rural Population;Sampling;Schedule;screening;service member;service utilization;Services;sex;Social outcome;Subgroup;substance use;Substance Use Disorder;Suburban Population;Symptoms;United States;Urban Population;Veterans;Veterans Health Administration

PROJECT_TITLE: Cannabis Use and Health among VHA Primary Care Patients

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: OVERALL PROJECT NARRATIVE  Age is the most important risk factor for developing Alzheimer’s disease and related dementias, but the mechanisms and development of successful treatments remain elusive. We propose to determine how age- related changes in both neurons and non-neuronal brain cells can drive these pathologies, with the long term goal of using these insights into effective interventions.

PI_NAMEs: ELLERBY, LISA M (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: 3-Dimensional;Affect;Age;age related;age related changes;age related neurodegeneration;Age-associated memory impairment;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Applications Grants;Astrocytes;Automobile Driving;Bioinformatics;Brain;brain cell;Cell Aging;Cell Communication;Cell Culture Techniques;Cell Death;cell type;Cells;Clinical;Collaborations;cost;Data;Dementia;Development;Disease;Disease Progression;Economics;effective intervention;effective therapy;Emotional;Endothelial Cells;Etiology;Family;Goals;Head;Human;induced pluripotent stem cell;Inflammation;insight;interest;Intervention;Knowledge;Macrophage;member;Metabolic;Metabolism;metabolome;Modeling;Molecular;mouse model;Mus;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurons;novel;novel strategies;Oligodendroglia;Organoids;Pathology;Patients;Pharmaceutical Preparations;Phenotype;Population;Productivity;Program Research Project Grants;programs;Proteome;Proteomics;Publishing;Recording of previous events;Research;Research Personnel;Research Project Grants;response;Risk;Risk Factors;Role;senescence;senescent cell;senolytics;social;Testing;Time;transcriptomics;Translating

PROJECT_TITLE: Cellular senescence and cell fate/interactions as drivers of Alzheimer's and age-related dementias


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE People rely on cognitive abilities to function in situations and natural environments experienced in daily life, but research studies assess cognition in “one-shot” in a laboratory or clinical setting, which can yield unreliable results. This study will develop a smartphone app carefully designed to assess cognition with several brief (<3 min) tests per day over the course of a week in people with Down syndrome (DS) at risk for Alzheimer’s disease (AD). If successful, this study will provide new insights into DS-AD and could lead to faster results from clinical trials.

PI_NAMEs: HASSENSTAB, JASON J (contact)

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: Address;Adoption;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease blood test;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;autosomal dominant Alzheimer's disease;autosome;Biological Markers;Blood;Cellular Phone;Chromosome 21;Clinic;Clinical;Clinical Trials;Cognition;Cognitive;cognitive ability;cognitive change;cognitive testing;cohort;cost;critical period;Data;design;Development;Devices;digital;digital assessment;Disease;disease phenotype;Down's Syndrome;effectiveness evaluation;Environment;Evaluation;Exhibits;experience;Fatigue;Focus Groups;genetic variant;Geography;Glial Fibrillary Acidic Protein;Goals;Guidelines;handheld mobile device;Hematological Disease;Human Resources;Impaired cognition;improved;Individual;insight;International;Laboratories;Language;Life;lifetime risk;Light;London;Measurement;Measures;Methodology;Methods;Moods;Nature;neurofilament;Observational Study;older adult;open source;Outcome;Paper;Participant;Performance;Persons;Phase;Phenotype;pilot test;Plasma;Population;Predisposition;prevent;Prevention trial;Process;Psychometrics;rate of change;Readiness;Research;research study;Risk;Role;Series;Serum;Site;Sleep;sleep pattern;smartphone application;smartphone based assessment;Source;Stress;stressor;Symptoms;synuclein;tau-1;Techniques;Technology;technology development;Testing;Therapeutic Intervention;Time;Validation;Work

PROJECT_TITLE: DS-ARC: A Remote Digital Cognitive Assessment for Down Syndrome-Associated Alzheimer's Disease

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: CLEMSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will examine adverse and protective factors that modify Black-White disparities in sleep, will elucidate whether sleep disparities relates to Black-White differences in risk for cognitive impairment, and will identify best practices for research engagement with underrepresented populations. Thus, the proposed research is relevant to the NIH's mission to reduce and/or eliminate health differences that are commonly observed between Blacks and Whites as well as enhance research engagement with diverse communities.

PI_NAMEs: GAMALDO, ALYSSA ANN (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: actigraphy;Address;Administrative Supplement;Adult;African American;Alzheimer's Disease;Alzheimer's disease related dementia;Award;Biological Markers;biopsychosocial;Black Populations;Black race;black/white disparity;Cognition;Cognitive;cognitive function;cognitive testing;Cognitive Therapy;cognitive training;cohesion;Communities;community based participatory research;Complex;contextual factors;coping;Coupling;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Collection;dementia risk;design;Devices;Disease;Disparity;Educational Intervention;Evaluation;Event;Evidence based intervention;experience;Exposure to;Financial Hardship;Funding;Future;Goals;Health;health difference;Health Disparities Research;health disparity;healthy aging;high risk;Human Resources;Impaired cognition;Impairment;improvement on sleep;Individual;Inflammation;Inflammatory;inflammatory marker;innovation;insight;Interleukin-10;Interleukin-6;Intervention;intervention program;Knowledge;Life;Life Cycle Stages;life span;Literature;Measures;Methods;middle age;mild cognitive impairment;Mission;Monitor;Neighborhoods;Neuropsychological Tests;Nonpharmacologic Therapy;pandemic disease;parent project;Parents;Participant;Performance;Population;Procedures;protective factors;Protocols documentation;Psychometrics;psychosocial;Psychosocial Assessment and Care;Psychosocial Factor;Public Health;Race;racial difference;racial disparity;racial diversity;recruit;Research;resilience factor;retention rate;Risk;Role;Sampling;Sleep;Sleep disturbances;sleep health;smartphone based assessment;social;social disparities;socioeconomics;Spirituality;stressor;success;Testing;time interval;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Variant;Videoconferencing;wireless;wireless fidelity;Work

PROJECT_TITLE: Psychosocial and Neighborhood Mechanisms and Consequences of Black-White Sleep Disparities on Cognition

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Public Health Relevance Identifying and understanding biological factors that promote opioid abuse and addiction can inform the development of novel therapeutic neuromodulation strategies that help combat the opioid epidemic. The proposed studies will test the hypothesis that fast-spiking interneurons in the nucleus accumbens represent a powerful modulator of motivational behaviors disrupted in addiction. Identifying novel circuits that can be harnessed to prevent and treat opioid use disorders is relevant to the NIH and NIDAs mission to tackle the opioid abuse epidemic.

PI_NAMEs: LEFEVRE, EMILIA M (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Acute;addiction;Amygdaloid structure;attenuation;Award;Behavior;behavioral pharmacology;behavioral plasticity;Biological Factors;Brain region;Calcium;career;career development;Cells;Chronic;combat;Cues;Data;Dependence;design;designer receptors exclusively activated by designer drugs;Development;drug seeking behavior;effective intervention;Electrophysiology (science);Epidemic;experimental study;Female;Fentanyl;fentanyl self-administration;Fiber;Foundations;Future;Genetic;genetic approach;Genetic Techniques;Goals;Image;in vivo;in vivo monitoring;innovation;Interneurons;Intervention;Knowledge;Maintenance;male;Mediating;Mediator;Mentors;Mentorship;Minnesota;Mission;Modeling;Molecular;Motivation;mu opioid receptors;Mus;National Institute of Drug Abuse;neural;neural circuit;Neurons;neuroregulation;novel;novel therapeutics;Nucleus Accumbens;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid use disorder;optogenetics;Oxycodone;patch clamp;Pathway interactions;Pattern;Pharmaceutical Preparations;Phase;Photometry;Play;Population;post-doctoral training;Postdoctoral Fellow;prevent;programs;Property;Protocols documentation;Psychological reinforcement;Public Health;public health relevance;Publications;Relapse;Research;response;reward circuitry;Rewards;Role;Self Administration;source localization;Synapses;Synaptic plasticity;Techniques;Testing;Thalamic structure;Therapeutic;tool;Training;translational therapeutics;United States National Institutes of Health;Universities;Viral

PROJECT_TITLE: Nucleus accumbens fast-spiking interneurons regulate opioid reward and addiction


NIH_SPENDING_CATS: Clinical Research;Cost Effectiveness Research;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: RELEVANCE (See instructions):  People living with HIV/AIDS remain untreated and more become newly infected each year. Many testing,  treatment, and prevention methods exist, raising critically important questions about which strategies to  employ when, where, and for whom, given varying epidemic features and resource constraints. We will  expand the CEPAC-I Model to address questions related to the impact of novel treatment and prevention  options and to determine which combinations of interventions will optimize HIV health outcomes globally.

PI_NAMEs: FREEDBERG, KENNETH ALAN (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS prevention;antiretroviral therapy;Award;Budgets;Caring;Characteristics;Clinical;clinical care;clinical implementation;Clinical Trials;Computers;cost;cost effectiveness;Country;Data;Developing Countries;Development;Epidemic;experience;Face;Funding;Goals;Guidelines;Health;high risk population;HIV;HIV Infections;HIV/AIDS;Human immunodeficiency virus test;improved;Incidence;innovation;insight;Instruction;International;Intervention;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;Natural History;NIH Office of AIDS Research;novel;Outcome;pandemic disease;Persons;Policies;Policy Maker;Population;prevent;Prevention;preventive intervention;Publications;Reduce health disparities;Research;Research Personnel;Research Priority;research study;Resource-limited setting;Resources;simulation;skills;Testing;treatment guidelines;treatment response

PROJECT_TITLE: Optimizing HIV Care in Less Developed Countries

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: RIVERSIDE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative Metalloproteins perform a wide range of chemical transformations whose functions are imperative for maintaining human health. The entire protein scaffold that houses the metallocofactor is responsible for controlling active site geometry, electronic structure of the metal center, reaction pathway, and substrate specificity. The ability to design proteins from scratch that bind metallocofactors and control substrate orientation will establish key structure-function relationships that govern the function and selectivity of efficient metalloenzymes.

PI_NAMEs: MANN, SAMUEL I (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: De novo design of functional metallocofactor-binding proteins


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Cancer mortality rates are projected to more than double in Sub-Saharan Africa (SSA) in the next two decades. In order to address this looming public health crisis, we propose a training program that will maximize the rigor of cancer research in SSA by training researchers to develop strategic and operational capacity that will generate new knowledge about the determinants of cancer risk and outcomes, and improve effectiveness of strategies for reducing risk and improve outcomes. The overarching goals of this training program are to 1) Develop and disseminate best practices to enable the highest quality cancer research in Africa; 2) Teach fundamental skills to those who conduct research in Africa; and 3) Create a cadre of individuals who can lead and support cancer research in SSA.

PI_NAMEs: REBBECK, TIMOTHY R (contact)

PROGRAM_OFFICER_NAME: SIVARAM, SUDHA

PROJECT_TERMS: Administrative Supplement;Africa;Africa South of the Sahara;African;African ancestry;anti-cancer research;Bilateral;Cancer Burden;cancer clinical trial;cancer risk;career;career development;Death Rate;Education;Educational Curriculum;Educational process of instructing;Effectiveness;experience;Extramural Activities;falls;Funding;Goals;Grant;Health;improved;improved outcome;Individual;interest;Knowledge;knowledge base;Lead;Leadership;Malignant Breast Neoplasm;Malignant neoplasm of esophagus;Malignant Neoplasms;men;Mentors;Oncology;Outcome;Participant;Principal Investigator;Program Development;programs;Prostate carcinoma;Public Health;Qualifying;recruit;Research;Research Personnel;Research Project Grants;response;Risk Reduction;skills;Training;Training and Education;Training Programs

PROJECT_TITLE: Administrative supplement to expand cancer clinical trial capacity in sub-Saharan Africa


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Residential segregation, one example of structural racism, has long been recognized as a root cause of disparities in the U.S. and imposes inequitable burden on marginalized communities. The proposed project aims to assess the extent to which residential segregation influences oil and gas development and fertility among couples attempting pregnancy, which will be the first to characterize and evaluate residential segregation during the preconception period. This work seeks to identify opportunities for environmental and reproductive intervention, which will inform the development of targeted interventions to improve population health.

PI_NAMEs: WILLIS, MARY D (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Address;aged;American;Area;Benzene;Black American;Black race;career;career development;Civil Rights;cohort;Cohort Studies;Collaborations;Communities;Complex;Conceptions;Couples;Crows;Data;Data Science;Data Set;Development;Development Plans;Discrimination;Disparity;Doctor of Philosophy;Economics;Educational workshop;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Hazards;Epidemiologist;epidemiology study;experience;Exposure to;Fertility;Formaldehyde;Fossil Fuels;Gases;Geography;Goals;Health;Hispanic;Hormonal Change;Housing;improved;indexing;Indigenous;Industry;Inequality;Inequity;Infertility study;Internet;Intervention;Investments;Irregular Menstruation;land use;Laws;Link;Low income;marginalization;marginalized community;marginalized population;Marketing;Menstrual cycle;Mentors;Mentorship;Methods;Modification;neighborhood disadvantage;Neighborhoods;North America;Oils;Outcome;Participant;participant enrollment;Pathway interactions;Pattern;people of color;perceived stress;Persons;Policies;population health;Positioning Attribute;Pregnancy;Prevalence;Probability;Prospective cohort;Prospective, cohort study;Psychological reinforcement;Race;racism;recruit;reproductive;reproductive epidemiology;Reproductive Health;Research;residential segregation;Risk;Scientist;segregation;Site;skills;social epidemiology;socioeconomic diversity;statistics;structural determinants;Structural Racism;Toluene;Toxicology;Training;translational potential;Work

PROJECT_TITLE: A preconception cohort study on oil and gas development, fertility, and pregnancy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(70)-R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: INDIANAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: NARRATIVE The overarching goal of the Utah Advanced Course on Cancer-related Health Disparities, Mentoring, Leadership is to provide innovative, state-of-the-art, evidence-based career development experiences to faculty to enhance their skills in cancer disparities research, mentoring and leadership. We bring expertise in mentoring and leadership training through the National Research Mentoring Network (NRMN), culturally tailored behavioral interventions, and cancer-related databases including population-databases that are unique to Utah.

PI_NAMEs: OKUYEMI, KOLAWOLE S (contact);SUNEJA, GITA

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: academic program;Address;Adopted;anti-cancer research;Applications Grants;Area;Award;Awareness;Behavior Therapy;Behavioral Research;Big Data;Biomedical Research;Cancer Burden;cancer health disparity;career;career development;Career Mobility;Climate;Clinical Research;cohort;Communication;Communities;community engaged research;COVID-19 pandemic;Databases;design;Discipline;Education;Education Projects;education research;Educational process of instructing;Educational Technology;evidence base;experience;Faculty;Fellowship;Funding;Goals;graduate student;Grant;Health Disparities Research;improved;Infusion procedures;innovation;Knowledge;Leadership;Malignant Neoplasms;Mediation;Medical Students;Medicare;Mental Health;Mentors;Morale;novel;pandemic disease;Participant;peer coaching;Performance;Persons;Population Database;Postdoctoral Fellow;professor;programs;Qualifying;recruit;Reporting;Research;research faculty;Research Personnel;Risk;Scientist;skill acquisition;skills;Talents;Teacher Professional Development;Time;Training;Training and Education;United States;United States National Institutes of Health;Universities;Utah

PROJECT_TITLE: Advanced Course on Cancer-related Health Disparities Research, Mentoring, & Leadership

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Hypoplastic left heart syndrome (HLHS) is a severe congenital heart defect that can lead to death of newborns within a week in the absence of surgical treatment. This R01 project aims to address how the aberrant intercellular communication between myocardium (cardiac muscle fibers) and endocardium (endothelial cells lining the interior of the heart) leads to HLHS using patient-derived induced pluripotent stem cells and CRISPR genome editing. Understanding how HLHS is developed would be pivotal to discover novel therapeutic treatment for this lethal disease.

PI_NAMEs: ZHAO, MINGTAO  (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: 3-Dimensional;access restrictions;Address;Affect;Animal Model;Animals;aortic valve;aortic valve disorder;Aortic Valve Stenosis;ascending aorta;bioprinting;Cardiac;Cardiac Myocytes;cardiogenesis;Cell Line;Cells;Clinical;clinical phenotype;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Communication;congenital heart abnormality;Congenital Heart Defects;CRISPR/Cas technology;Data;Defect;design;Development;Disease;Electrophysiology (science);Elements;Embryo;Endocardium;Endothelial Cells;Endothelium;exosome;Gene Dosage;Generations;Genetic;Genetic Engineering;genome editing;Genotype;Growth;Heart;Heart Atrium;Heart Diseases;Human;human induced pluripotent stem cells;human stem cells;Hypoplastic Left Heart Syndrome;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;intercellular communication;Interruption;Knowledge;Lead;Left;Left ventricular structure;Link;Mediating;Mitral Valve;Molecular;Morphogenesis;mouse model;Muscle Fibers;Mutation;Myocardial;Myocardium;Neonatal Mortality;Newborn Infant;Nodal;notch protein;NOTCH1 gene;novel;novel therapeutics;Operative Surgical Procedures;patch clamp;Pathogenicity;patient derived induced pluripotent stem cells;Patients;prevent;Proliferating;Proteomics;Publishing;Running;Side;Signal Transduction;single-cell RNA sequencing;Small RNA;stem cell model;stem cells;Structural defect;Structure;Study models;System;Tissues;transcriptome sequencing;Variant;Ventricular

PROJECT_TITLE: An integrated human stem cell model for elucidating NOTCH signaling in myocardial-endocardial interactions in cardiac development and disease


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Prescription Drug Misuse;Prevention;Recovery Support Services;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: PROJECT NARRATIVE: Chronic pain and hazardous opioid use are major public health problems, particularly in military veterans. The major goal of this supplement project is to finalize recruitment, treatment and follow- ups of a multisite randomized clinical trial to test the efficacy of an innovative behavioral treatment for patients with chronic pain who are prescribed buprenorphine for the treatment of opioid use disorder. This project supports the strategic goals of several NIH institutes by examining a difficult and understudied problem with the ultimate goal of impacting scientific knowledge and human health.

PI_NAMEs: VOWLES, KEVIN E;WITKIEWITZ, KATIE A (contact)

PROGRAM_OFFICER_NAME: AKLIN, WILL

PROJECT_TERMS: active method;Address;Aftercare;Agreement;Behavior Therapy;Buprenorphine;buprenorphine treatment;Case Report Form;chronic pain;chronic pain management;chronic pain patient;Clinic;Clinical;clinical care;Clinical Protocols;clinical research site;Clinical Trials Design;clinically significant;Common Data Element;comorbidity;cost;craving;dual diagnosis;Education;effectiveness research;efficacy evaluation;efficacy testing;Evidence based treatment;feasibility testing;follow-up;Fright;Goals;Grant;Health;Healthcare Systems;Human;Human Resources;Individual;innovation;Intervention;Knowledge;Mental Depression;military veteran;mindfulness;Mindfulness Training;Modeling;Morbidity - disease rate;mortality;multi-site trial;National Center for Complementary and Integrative Health;Opiate Addiction;Opioid;opioid misuse;opioid use;opioid use disorder;Outcome;Pain;Pain intensity;Pain interference;Pain management;pain reduction;parent project;Parents;Participant;Patient Self-Report;Patients;Phase;Physicians;Pilot Projects;prescription opioid;prescription opioid misuse;preventive intervention;primary outcome;Procedures;Process;programs;Psychology;psychosocial;Psychosocial Assessment and Care;Public Health;Randomized;randomized, clinical trials;recruit;relapse prevention;Reporting;Research;Risk;Sampling;secondary outcome;Site;Specific qualifier value;substance misuse;substance use;substance use prevention;Therapeutic;Training;Treatment outcome;United States;United States Department of Veterans Affairs;United States National Institutes of Health;Urine;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Integrated Treatment for Veterans with Co-Occurring Chronic Pain and Opioid Use Disorder


ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PI_NAMEs: ADAMS, PETER D. (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Bioinformatics;Cancer Center;Cancer Center Support Grant;cancer genome;Cells;Clinical;Collaborations;disease model;Epigenetic Process;Funding;Goals;Human;Maintenance;Malignant Neoplasms;member;programs;recruit;Resources;Sampling;Signal Transduction;Strategic Planning;Therapeutic;tumor;tumor initiation

PROJECT_TITLE: Cancer Genome & Epigenetics


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Complementary and Integrative Health;Natural Products

ORG_DEPT: DENTISTRY

PHR: Project Narrative This project is focused on the identification of novel intracellular inputs to stress-activated signaling pathways. These inputs are critical to elicit the normal cellular responses to a wide variety of chemical and physical stress conditions, including heat shock, environmental toxins, and genotoxic stress. Such cellular responses help to maintain cellular integrity, metabolism, and genomic stability and are important in the treatment and prevention of cancer and other diseases.

PI_NAMEs: LEVIN, DAVID E. (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Acetic Acids;acid stress;Address;Alzheimer's disease therapeutic;Arsenites;Automobile Driving;Biochemical;cancer prevention;Cell surface;Cell Wall;Cells;Chemicals;Clinical Trials;Curcumin;Data;Disease;DNA Damage;DNA damage checkpoint;endoplasmic reticulum stress;Environment;Evolution;Funding;Genetic;genetic approach;Genetic Screening;Genome Stability;Genotoxic Stress;Glycerol;Growth;Heat-Shock Response;Histidine;insight;interest;Malignant Neoplasms;MAP3K1 gene;MEKKs;MEKs;Metabolism;Modeling;Nature;novel;Osmolar Concentration;Osmosis;Output;Oxidative Stress;Pathway interactions;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;protein degradation;Protein phosphatase;Proteins;recruit;response;Role;Route;Saccharomyces cerevisiae;Scaffolding Protein;shear stress;Signal Pathway;Signal Transduction;Spices;Stress;stress activated protein kinase;stressor;Toxic Environmental Substances;Toxin;Tumeric;upstream kinase;Yeasts

PROJECT_TITLE: Intracellular Stress Inputs to SAPK Signaling Pathways


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: COMMISSO, COSIMO  (contact)

PROJECT_TERMS: Address;Applications Grants;Area;Autophagocytosis;Biology;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;Cell Survival;Cellular biology;Chemicals;Collaborations;efficacious treatment;endoplasmic reticulum stress;Equilibrium;Event;expectation;Faculty;Genomics;Goals;high throughput screening;Innovative Therapy;Knowledge;Leadership;Libraries;Malignant Neoplasms;member;metabolic abnormality assessment;Molecular Biology;multicatalytic endopeptidase complex;new therapeutic target;Pharmaceutical Chemistry;pharmacologic;preclinical study;programs;Protein Biosynthesis;protein degradation;recruit;Research;System;targeted cancer therapy;Translating;Translational Research;tumor metabolism;tumor microenvironment

PROJECT_TITLE: Cancer Metabolism & Microenvironment


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

PI_NAMEs: JACKSON, MICHAEL  (contact)

PROJECT_TERMS: Aging;Biological Products;cancer cell;Cancer Center Support Grant;cancer imaging;cancer therapy;Cancer Vaccines;Cells;Collaborations;Combined Modality Therapy;Development;Epigenetic Process;Goals;Grant;Growth;Hematologic Neoplasms;Immune;Immune system;Immunooncology;Immunotherapy;individual patient;Infection;Knowledge;Malignant Neoplasms;member;Metabolic;Modeling;Molecular;Neoplasm Metastasis;novel;novel strategies;novel therapeutics;programs;Proteomics;Research;Solid;Stromal Cells;Therapeutic;transcriptomics;translational study;tumor;tumor immunology;tumor progression

PROJECT_TITLE: Cancer Molecular Therapeutics


ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: NARRATIVE This project will have a significant impact on the fundamental understanding of bacterial physiology by determining why ribosome rescue pathways are essential for bacteria, providing the first structural and biochemical pictures of ribosomal interactions required for ribosome rescue, and providing biochemical and structural information that will allow rational optimization of the activity of ribosome rescue inhibitors. These studies will enable development of ribosome rescue inhibitors as new antibiotics. Therefore, this work will have a large and direct impact on improving human health.

PI_NAMEs: DUNHAM, CHRISTINE M;KEILER, KENNETH C (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Affect;Antibiotics;Bacteria;Bacterial Genome;Bacterial Physiology;Binding;Biochemical;Biological;Biology;Caulobacter crescentus;Cells;Chemicals;Data;Development;experimental study;Foundations;Funding;Genes;Genetic;Goals;Grant;Growth;Health;Homologous Gene;Human;Hydrolysis;improved;inhibitor;innovation;insight;Knowledge;Messenger RNA;Molecular;Molecular Target;mRNA Transcript Degradation;Multi-Drug Resistance;Mutation Analysis;Outcome;Oxidative Stress;pathogenic bacteria;Pathogenicity;Pathway interactions;peptidyl-tRNA;pharmacologic;Phylogenetic Analysis;Physiological;Physiology;polypeptide;Process;Property;Publishing;recruit;Research;Ribosomal Interaction;Ribosomal Proteins;Ribosomes;RNA;Role;small molecule;small molecule inhibitor;SmpB protein;Solid;Structure;System;Terminator Codon;Testing;tmRNA;tool;Translating;translation factor;Translations;Virulence;Work

PROJECT_TITLE: Physiology of ribosome rescue in bacteria

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Short tandem repeats (STRs) are repetitive DNA sequences that cause dozens of genetic diseases in humans and are difficult to sequence and interpret, leaving individuals with STR-associated disease undiagnosed. This proposal will establish a genetic diagnosis for hundreds of patients, while searching for new STR disease loci. To accomplish this, we will develop new computational approaches and call STRs across the genome in thousands of individuals to establish a population-scale STR catalog, with an emphasis on diverse and under- served populations.

PI_NAMEs: DASHNOW, HARRIET  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Address;Alleles;Catalogs;Child;cohort;Communities;contig;Data;Data Set;Databases;Detection;detection method;Diagnosis;Disease;disease diagnosis;DNA Sequence;Dropout;empowerment;Exclusion;experience;Frequencies;Funding;Future;Gene Expression;Gene Frequency;Gene Order;Genetic Diseases;genetic disorder diagnosis;Genome;genome sequencing;genome-wide;Genomics;Genotype;Hospitals;Human;human disease;Human Genome;Incidence;Individual;innovation;insertion/deletion mutation;Investigation;Medical Research;Methods;Mutation;nanopore;National Human Genome Research Institute;novel;Pathogenicity;Patients;Phenotype;Population;Population Heterogeneity;Rare Diseases;rare genetic disorder;Repetitive Sequence;Research;Research Personnel;Resources;Scheme;Short Tandem Repeat;Single Nucleotide Polymorphism;Stretching;Stuttering;Technology;Trans-Omics for Precision Medicine;Underserved Population;Universities;Untranslated RNA;Variant;Washington;whole genome;Work

PROJECT_TITLE: Revealing new short tandem repeat variation in the human population across sequencing technologies: towards rare disease diagnosis and discovery

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Cardiac arrhythmias (abnormal heart rhythms) remain a leading cause of death in the United States in part due to abnormal calcium cycling in the heart. This project aims to gain novel insights into the impact of mitochondria on calcium cycling, thereby contributing to our understanding of arrhythmogenesis. Findings from these studies will offer valuable guidance for the development of new therapies targeting heart disorders, particularly calcium- dependent arrhythmias.

PI_NAMEs: LIU, BIN  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: absorption;Arrhythmia;Biological Assay;Calcium;Calcium Oscillations;career;career development;Catecholaminergic Polymorphic Ventricular Tachycardia;Cause of Death;Cellular Assay;Complex;confocal imaging;Defect;Dependovirus;Development;doctoral student;Electrocardiogram;Engineering;experimental study;Florida;Frequencies;Functional disorder;Future;Gene Transfer;Genetic;Growth;Heart;Heart Abnormalities;Heart Diseases;Heart failure;heart rhythm;Hyperactivity;Immunofluorescence Immunologic;in vivo;innovation;insight;interest;Ligation;Measurement;Mediating;Membrane;Metabolic;Mission;Mitochondria;Muscle Cells;Mutation;Myocardial dysfunction;Myocardium;new therapeutic target;novel;parent project;Play;Process;Proteins;research and development;Role;Ryanodine Receptor Calcium Release Channel;Sarcoplasmic Reticulum;Site;skills;Surface;Syndrome;Testing;Training;training opportunity;Transmission Electron Microscopy;United States;United States National Institutes of Health;Universities;uptake

PROJECT_TITLE: Exploring the impact of enhancing SR-mitochondria tethering on Ca-dependent arrhythmias


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Neurons in the brain are precisely orchestrated to provide an internal representation of our environment, a vital yet incompletely understood function. Here, we focus our attention on an overlooked population of inhibitory neurons in the brain to investigate how synapses and neurons cooperate to synchronize neuronal activity across a network. The proposed research will expand our knowledge on the fundamental mechanisms underlying neuronal network coordination, with our findings having potentially far-reaching impact for our understanding of neurological disorders such as autism spectrum disorders, schizophrenia, and epilepsies.

PI_NAMEs: CHAMBERLAND, SIMON  (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Action Potentials;Acute;anatomical tracing;Animals;Architecture;Attention;autism spectrum disorder;Award;Back;Behavior;Brain;Brain region;career;cognitive function;comparative;Complex;Data;Disinhibition;Electrophysiology (science);Environment;Epilepsy;excitatory neuron;Experimental Designs;Fire - disasters;Frequencies;genetic approach;Goals;hippocampal pyramidal neuron;Hippocampus;In Vitro;in vivo;Individual;Inferior;inhibitory neuron;Interneurons;Interruption;Intervention;Investigation;Knowledge;Learning;Lifting;Location;Maintenance;Measurable;Measures;medical schools;Membrane Potentials;Memory;memory retrieval;Mentorship;millisecond;Motivation;Motor;Nervous System Disorder;Neurons;Neurosciences;New York;optogenetics;Parvalbumins;Pathologic;Pattern;Phase;Physiological;Population;Population Heterogeneity;Preparation;preservation;Property;Pyramidal Cells;recruit;Recruitment Activity;Research;Rewards;Role;Schizophrenia;skills;Slice;spatial memory;Speed;Subcellular Anatomy;Synapses;synaptic inhibition;Synaptic Transmission;System;Time;Training;Universities;way finding;Whole-Cell Recordings;Work

PROJECT_TITLE: Synaptic and cellular mechanisms of neuronal synchronization


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative;Neurosciences

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PI_NAMEs: MOR, VINCENT  (contact)

PROGRAM_OFFICER_NAME: BHATTACHARYYA, PARTHA

PROJECT_TERMS: Aging;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;care outcomes;care systems;career development;Caregivers;Caring;Clinical Trials;Clinical Trials Design;Collaborations;collaboratory;Committee Members;Communication;Complex;Data;data enclave;data sharing;data standards;Databases;Dedications;Dementia;design;Development;diversity and inclusion;Doctor of Philosophy;Elements;Ensure;experience;Funding;Grant;Healthcare Systems;Home;Human Resources;improved;Infrastructure;innovation;Institution;Institutional Review Boards;K-Series Research Career Programs;Knowledge;Leadership;Life;Life Cycle Stages;Link;Logistics;Maintenance;National Institute on Aging;Outcome;Persons;Pilot Projects;Pragmatic clinical trial;Preparation;Principal Investigator;Productivity;Public Health Schools;Recording of previous events;Research;Research Design;Research Infrastructure;Research Personnel;Resources;Role;Scientist;service providers;Services;Site;Structure;success;Sum;systems research;training opportunity;United States National Institutes of Health;Universities;web site;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health

PI_NAMEs: BYNUM, JULIE PW (contact)

PROJECT_TERMS: Acceleration;acute care;Address;Adherence;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Assisted Living Facilities;career development;Caregivers;Caring;Categories;Clinical;Clinical Trials;Code;cohort;collaboratory;Collection;Committee Members;Complex;complex data;Conduct Clinical Trials;cost effective;Data;Data Collection;Data Set;data sharing;Data Sources;Day center care;Dementia;design;Development;Diagnosis;Disease;Electronic Health Record;Elements;Eligibility Determination;Enrollment;ethnic minority;evidence base;experience;falls;follow-up;Funding;Future;Geographic Locations;Geriatrics;Goals;Health;health care delivery;Health system;Healthcare Systems;hospice environment;ICD-9;improved;Informatics;Intervention;Measures;Medical;medical information system;Medicare;Medicare claim;Medicine;Methodology;Methods;Michigan;Monitor;National Institute on Aging;Natural Language Processing;Nonpharmacologic Therapy;Notification;Nursing Homes;older adult;Outcome;Outcome Measure;Palliative Care;Participant;patient home care;Patients;Persons;Pilot Projects;Population;Pragmatic clinical trial;Privatization;Process;professor;Provider;Publishing;Quality of Care;racial minority;Recommendation;Records;recruit;Registries;Reporting;Research;Research Personnel;Resources;Site;Source;Standardization;Stigmatization;System;systems research;Testing;Time;tool;United States National Institutes of Health;Universities;Work;World Health

PROJECT_TITLE: Technical/Data Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health

PI_NAMEs: KARLAWISH, JASON H (contact)

PROJECT_TERMS: Accounting;Address;Adult;Affect;Agitation;Alzheimer's Disease;Alzheimer's disease related dementia;American;authority;care outcomes;career development;Caregivers;Caring;Collaborations;collaboratory;Communities;cost of dementia;decision-making capacity;Dementia;dementia care;Dementia caregivers;Disease;Distress;Doctor of Medicine;Eating;Economic Burden;efficacy trial;Emotional;Enrollment;Equilibrium;Ethical Issues;Ethics;evidence base;experience;Familiarity;Family;Financial Hardship;Foundations;Funding;Gatekeeping;Geriatrics;Goals;Group Homes;Guidelines;Health;Health Policy;Healthcare Systems;Human Resources;Impairment;improved;Individual;Informed Consent;Institutional Review Boards;Insurance;interest;International;Intervention;investigator training;K-Series Research Career Programs;Laws;Linguistics;multidisciplinary;National Institute on Aging;Nomenclature;novel;novel strategies;Nursing Homes;Office for Human Research Protections;Pain;Patients;Persons;Physical Sufferings;Pilot Projects;Policies;Positioning Attribute;Pragmatic clinical trial;prevent;Process;programs;Regulation;Research;Research Personnel;Resources;Role;Running;Services;Shapes;social;social stigma;Structure;Symptoms;System;systems research;Training;United States National Institutes of Health;Vulnerable Populations;Work;working group

PROJECT_TITLE: Regulation & Ethics Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences

PI_NAMEs: ALLORE, HEATHER GWYNN (contact)

PROJECT_TERMS: Address;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Biometry;career;career development;Caregivers;Caring;Clinical;Clinical Investigator;Cluster randomized trial;Code;Collaborations;collaboratory;Committee Members;Complex;Computer software;Conduct Clinical Trials;Consultations;Data;Data Coordinating Center;data registry;Dementia;design;Development;Doctor of Philosophy;Documentation;Effectiveness;Electronic Health Record;Elements;Ensure;experience;Funding;Gerontology;Goals;Health;health assessment;Healthcare Systems;Heterogeneity;improved;innovation;insight;instrument;Intervention;K-Series Research Career Programs;Knowledge;knowledge repository;Leadership;Measurement;medical schools;Medicine;Mentors;Methodology;Methods;National Institute on Aging;novel;Older Population;Outcome;Patients;Personal Satisfaction;Persons;Pilot Projects;Population;Pragmatic clinical trial;prevent;Privatization;Procedures;professor;Public Health Schools;Publications;quality assurance;Randomized;Records;Reporting;Reproducibility;Research;Research Design;Research Personnel;Resources;Sample Size;Scientist;Services;sex as a biological variable;software development;Statistical Data Interpretation;statistics;Subgroup;systems research;Techniques;Testing;Textbooks;Time;Training;Underrepresented Minority;United States National Institutes of Health;Validity and Reliability;Vulnerable Populations;Work;working group

PROJECT_TITLE: Design-Statistical Core