ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Heart Disease;Neurosciences;Prevention;Sleep Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Relevance People with type 1 diabetes are disproportionately affected by cardiovascular disease (CVD). Short and irregular sleep have been associated with cardiovascular risk in this population. Improving sleep regularity has been associated with improved glycemic markers however mechanisms by which improving sleep regularity improves metabolic and cardiovascular health is not known. We propose to conduct a mechanistic study using a sleep stability manipulation. This proposal will advance the understanding of mechanisms by which improving sleep regularity influences glycemic control and cardiovascular risk in T1D.

PI_NAMEs: MARTYN-NEMETH, PAMELA ANN (contact);REUTRAKUL, SIRIMON

PROJECT_TERMS: 6-sulfatoxymelatonin;actigraphy;Adult;Affect;American;American Heart Association;Behavioral;behavioral sleep intervention;Biological Markers;blood glucose regulation;Blood Pressure;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;carotid intima-media thickness;Cause of Death;circadian;Circadian desynchrony;circadian pacemaker;circadian regulation;cohort;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Data;design;diabetes distress;Diabetes Mellitus;Dilatation - action;Disease;Echocardiography;Endothelial Cells;endothelial dysfunction;Endothelium;Event;experience;Experimental Designs;experimental study;Foundations;General Population;Genes;Glucose;glucose metabolism;glycemic control;Goals;Health;Health behavior;Hemoglobin;human disease;Impairment;improved;improved outcome;improvement on sleep;Individual;Insulin;Insulin Resistance;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Intervention;Knowledge;Light;Link;Measurement;Measures;Mediating;Melatonin;men;Metabolic;Metabolic Diseases;Moods;mortality;mRNA Expression;Muscle function;National Heart, Lung, and Blood Institute;Nitroglycerin;Non-Insulin-Dependent Diabetes Mellitus;Observational Study;Outcome;Patient Self-Report;Peripheral;Persons;Physical activity;Physiologic pulse;poor sleep;Population;Prevention;Psychological Factors;Quality of life;Research;Rest;Risk;Risk Marker;Sleep;Sleep Deprivation;Sleep disturbances;sleep health;sleep quality;sleep regulation;Stress;System;Testing;Time;United States National Institutes of Health;urinary;Vascular Smooth Muscle;Woman;young adult

PROJECT_TITLE: Circadian Mechanisms of Glycemic Control and Cardiovascular Risk in Adults with Type 1 Diabetes


ADMINISTERING_IC: DA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Pediatric;Prevention;Screening and Brief Intervention for Substance Misuse;Substance Misuse;Substance Misuse Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: PARTNERSHIP TO END ADDICTION

ORG_STATE: NY

PHR: Project Narrative Substance use in the early postpartum period is an urgent public health problem that can interfere with a mother’s ability to care for her baby, and is associated with increased risk for child abuse and neglect and poor long-term child health and developmental outcomes. Systems that serve postpartum mothers often fail to identify and adequately address substance use, missing prime opportunities for preventing negative outcomes. The proposed R34 will further refine an innovative digital screening and brief intervention for postpartum substance use designed for use in evidence-based home visiting programs.

PI_NAMEs: DAUBER, SARAH E. (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: acceptability and feasibility;Address;automated text message;brief intervention;Cellular Phone;Child;Child Abuse and Neglect;Child Health;Child Welfare;Client;Clinical Skills;clinical training;Companions;Data;design;Development;digital;digital delivery;effective therapy;effectiveness/implementation design;Electronics;Empathy;evidence base;Excision;Family;Feedback;Fright;Future;Goals;health care settings;high risk;Home;Home visitation;hybrid type 2 trial;implementation barriers;implementation context;implementation evaluation;implementation facilitators;implementation framework;implementation strategy;Individual;Infant Care;innovation;Intervention;intervention delivery;intervention effect;Interview;Kansas;Literature;Maternal and Child Health;Methods;Modeling;Mothers;Motivation;motivational enhancement therapy;Outcome;Participant;Perinatal;perinatal intervention;perinatal period;Persons;Phase;Pilot Projects;post implementation;Postpartum Period;Practical Robust Implementation and Sustainability Model;Practice Management;Pregnancy;prepregnancy;preservation;prevent;Process;programs;Protocols documentation;Provider;Public Health;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Recommendation;Risk;screening and brief intervention;screening, brief intervention, referral, and treatment;Self Efficacy;Services;Site;social stigma;Standardization;substance use;substance use prevention;substance use treatment;System;tailored text messaging;Testing;Text Messaging;Time;tool;Woman;Work

PROJECT_TITLE: Digital Screening and Brief Intervention for Perinatal Substance Use in Home Visiting

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: Aurora

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative: Understanding the impact that RNA motifs have, on its structure and function, is of importance to assess their biological roles; this information can be leveraged to control/regulate the biological outcome of different RNA- derived mechanisms. This proposal will establish the 5'-GUAC- palindromic sequence as a motif, while understanding the nature of its unique structural behavior. This will aid in understanding how the presence of this sequence in various types of RNA impacts interactions with other biopolymers and metabolites, thus making it a potential target for drugs or proteins.

PI_NAMEs: RESENDIZ, MARINO JE (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;8-hydroxyguanosine;Adopted;analog;Behavior;Binding;Bioinformatics;Biological;Biological Process;biological systems;Biology;biophysical techniques;Biopolymers;Calorimetry;Chemicals;Circular Dichroism;Complement;Coronavirus;crosslink;Data;Disease;DNA;Drug Targeting;druggable target;Electrophoresis;Electrostatics;Elements;Equilibrium;Exhibits;Experimental Designs;Future;Hereditary Disease;Human;innovation;interest;Measures;Methodology;MicroRNAs;Modeling;Modification;Molecular Conformation;Nature;Oligonucleotides;Organic Synthesis;Organism;Outcome;Outcome Study;phosphoramidite;Play;Positioning Attribute;Property;Proteins;Research;Research Personnel;RNA;RNA Sequences;RNA-Binding Proteins;Role;S phase;SARS coronavirus;Shapes;Site;small molecule;Solid;stem;Structure;therapeutic target;Time;Transfer RNA;Untranslated RNA;viral RNA;Virus;Work;X-Ray Crystallography

PROJECT_TITLE: Exploring the 5'-GUAC- sequence as an important RNA-motif

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Neurodegenerative;Neurosciences;Prevention;Primary Health Care;Sleep Research

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Cognitive impairment (CI), including Alzheimer’s disease and related dementias (ADRD), are prevalent in later life with limited treatment options. Sleep disturbance (SD) is a significant risk factor for the development of CI/ADRD in older adults. This project seeks to examine how specific types of SD may be associated with poorer cognitive function and worse health outcomes earlier - among younger, middle-aged adults. We will develop and pilot test an efficient, scalable, primary care strategy for the routine detection of SD to mitigate CI/ADRD risk.

PI_NAMEs: KIM, MINJEE  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: actigraphy;Address;Adult;Age;Aging;Alzheimer's disease related dementia;American;Anxiety;Attention;Award;Behavioral;Biometry;Capsicum;career development;Chronic;circadian;Clinical;Clinical assessments;clinical care;clinical investigation;Clinical Sciences;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive testing;Cohort Studies;comorbidity;Data;Data Science;Dedications;dementia risk;design;Detection;detection test;Development;Development Plans;Diagnostic;diaries;Drowsiness;Early Diagnosis;Early identification;Early Intervention;Early treatment;efficacy outcomes;Electronic Health Record;Ensure;Environment;Epidemiology;Episodic memory;Evaluation;executive function;experience;Foundations;Future;Goals;Health;Health Benefit;Health Status;Health system;human old age (65+);Impaired cognition;improved;improvement on sleep;Intervention;Investigation;Knowledge;late life;Lead;Link;Liquid substance;longitudinal analysis;Machine Learning;machine learning method;Measures;Medicine;Mental Depression;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;middle age;Modeling;Neurologist;Neurology;novel;older adult;Outcome;Parents;Patient Self-Report;Patients;Pattern;Phenotype;physical conditioning;pilot test;poor health outcome;poor sleep;Positioning Attribute;Pragmatic clinical trial;pragmatic trial;predictive modeling;preservation;Prevalence;Primary Care;primary care clinician;primary care practice;primary care setting;processing speed;psychosocial;Quality of life;Questionnaires;Recommendation;Research;Research Personnel;Research Support;Resources;Risk;Risk Factors;risk mitigation;risk prediction;risk prediction model;Role;screening;Self Care;Site;skills;Sleep;Sleep disturbances;sleep health;Stress;Testing;Time;Training;Translating;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: Sleep Health and Cognitive Function among Middle-aged Adults: the SleepCog Study

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: LEXINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE This study investigates the role of Transforming Growth Factor-Activated Kinase 1 (TAK1) in tau pathology after mild traumatic brain injuries, focusing on the potential of BNC-1 therapy to alleviate pathological tau and neurodegeneration in TBI and Alzheimer's disease. The research aims to deepen our understanding of the mechanisms behind tau accumulation in conditions like TBI, Alzheimer's disease, and other related tauopathies.

PI_NAMEs: BACHSTETTER, ADAM D (contact);LOVELL, MARK ANTHONY

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: Acute;Address;Adverse effects;Age;Age Months;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Amyloid;Behavioral;behavioral impairment;Biochemical;Brain;carboxylate;Caring;Cell Count;Chronic;chronic traumatic encephalopathy;Clinical Research;Clinical Trials;Closed head injuries;Data;Dementia;Deterioration;Development;Diet;DLG4 gene;dosage;Dose;drebrins;drug discovery;drug efficacy;Drug Kinetics;Evaluation Research;Exhibits;experience;experimental group;fall injury;Female;Future;Genetically Engineered Mouse;Goals;Head;High Prevalence;human old age (65+);hyperphosphorylated tau;Impaired cognition;In Vitro;Incidence;Individual;injured;Injury;Intervention;Knock-in Mouse;Lead;Legal patent;Link;male;Medical;mild traumatic brain injury;mouse model;Mus;Naphthyridines;Nerve Degeneration;Neurons;neuropathology;novel;older adult;Older Population;optimal treatments;Oral;overexpression;Pathologic;Pathology;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phenotype;PHF-1;Phosphorylation;Phosphotransferases;Population;pre-clinical;preclinical study;Predisposition;prevent;primary endpoint;Process;Research;response;Risk;Risk Reduction;risk variant;Role;severe injury;small molecule therapeutics;Speed;Synapses;Synapsins;Synaptophysin;targeted treatment;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Transforming Growth Factors;Traumatic Brain Injury;treatment effect;Treatment Protocols;Wild Type Mouse

PROJECT_TITLE: Therapeutic Value of BNC-1 in Addressing Tau Pathology in TBI

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-B (55)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Pediatric;Prevention;Sleep Research

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Later sleep timing has been identified as a risk factor for youth-onset type 2 diabetes, yet adolescents adopt later sleep patterns (chronotype) as part of normal development. Current literature on sleep timing and its relationship to glucose metabolism may not apply to older adolescents and young adults with later chronotype, as morning testing may be mis-aligned with the schedule of these youth, leading to the potential for misleading results and/or misdiagnoses. This project will assess whether delaying the timing of testing for diabetes risk in youth with late chronotype improves testing results both in our research lab and in a real-world setting, to gain a better understanding of the diabetes risk for this understudied population.

PI_NAMEs: HITT, TALIA  (contact)

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: actigraphy;Address;Adolescent;Adolescent and Young Adult;Adopted;Advisory Committees;Area;Area Under Curve;Award;Beds;blood glucose regulation;Body mass index;career;career development;Childhood;Chronobiology;circadian;Circadian Rhythms;Clinical;Consumption;Continuous Glucose Monitor;Cross-Over Studies;Data;Data Analyses;Development;Diabetes Mellitus;diabetes risk;Diagnosis;Diagnostic;Disease;Eating;Exhibits;experimental study;Future;Glucose;Glucose Intolerance;glucose metabolism;glucose tolerance;Goals;Health;Hour;impaired glucose tolerance;Impairment;improved;Incidence;Individual;insulin sensitivity;K-Series Research Career Programs;Life Style;Light;Link;Literature;mathematical model;Measures;Mediating;Mediator;meetings;Melatonin;Mentors;Mentorship;Metabolic;Metabolism;Microvascular Dysfunction;Modeling;modifiable risk;multidisciplinary;Non-Insulin-Dependent Diabetes Mellitus;novel;OGTT;Oral;Outcome;Overweight;Participant;Pattern;Phenotype;Physiological;Physiological Processes;Population;primary outcome;Randomized;Recommendation;Research;Research Activity;Research Design;Research Personnel;research study;Resources;response;Risk;Risk Factors;Role;Salivary;Schedule;skills;Sleep;Sleep Disorders;sleep onset;sleep pattern;Standardization;Strigiformes;supportive environment;symposium;Test Result;Testing;therapy design;Time;tool;Training;university student;young adult;Youth

PROJECT_TITLE: Night Owl Metabolism: Investigating the Impact of Chronotype on Glucose Metabolism in Youth

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Signaling proteins like bacterial histidine kinases act as switches, sensing environmental stimuli and initiating a cellular response through a series of conformational changes and enzymatic steps. For these predominant receptors, we still lack significant understanding of how signals are propagated through the protein scaffold to induce switch-like behavior. By design signaling components from scratch and engineering them into signaling proteins, we can interrogate signaling mechanisms from first principles, bringing us closer to a molecular level understanding how nature has evolved dynamic yet specific signaling pathways.

PI_NAMEs: HATSTAT, ANNA KATHERINE (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Revealing signal transduction mechanisms through protein design

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-A (KR)]


NIH_SPENDING_CATS: Dietary Supplements;Kidney Disease;Nutrition;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Maintaining mineral and bone metabolism in homeostasis is critical, and disruption of hormonal regulators of mineral metabolism can have significant consequences. Both chronic kidney disease mineral and bone metabolism (CKD-MBD) and hypoparathyroidism show insufficient 1,25-vitamin D levels, which affect mineral metabolism, kidney and bone health. Here, we hypothesize that inhibition of salt-inducible kinases, downstream mediators of PTH actions in kidney and bone, will result in desirable PTH-like effects by stimulating 1,25-vitamin D and bone formation.

PI_NAMEs: YOON, SUNG-HEE  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Acceleration;Acute;Affect;Animals;Binding;Biochemical Markers;Bioinformatics;biomechanical test;Biomechanics;Blood coagulation;bone;Bone Diseases;bone health;bone mass;bone metabolism;bone turnover;Bypass;Calcium;career;Cartilage;Catabolism;Cell Nucleus;ChIP-seq;Chronic;Chronic Kidney Failure;Clinical;Complex;Complication;CYP27B1 gene;Data;Disease;disease model;Dose;effective therapy;Enhancers;Enzymes;experience;Functional disorder;Gene Expression Regulation;Generations;genomic locus;Genomic Segment;Goals;HDAC4 gene;HDAC5 gene;Health;Histone Deacetylase;Homeostasis;Hormonal;hormonal signals;hormone resistance;Hormones;Hypoparathyroidism;improved;Injury;inorganic phosphate;insight;K-Series Research Career Programs;Kidney;kinase inhibitor;Knowledge;Measures;Mediating;Mediator;Mentors;Metabolic Bone Diseases;Metabolic Diseases;Metabolism;microCT;Minerals;Modeling;Molecular;mouse model;Mus;Muscle;Nerve;Normal Range;novel;Operative Surgical Procedures;Osteocytes;Osteogenesis;Parathyroid Hormone Receptor;Parathyroidectomy;Pathologic;Pathway interactions;Patients;Physiological;Play;podocyte;Process;Production;Property;Protein Dephosphorylation;PTH gene;rare condition;receptor;Receptor Activation;Receptor Signaling;Regulation;Reporting;Repression;response;Role;salt-inducible kinase;Secondary Hyperparathyroidism;Serum;Serum Calcium Level;Signal Pathway;skeletal;skeletal abnormality;skill acquisition;skills;Testing;Therapeutic;Training;training opportunity;transcription factor;translational study;Urine;Vitamin D;Wild Type Mouse;Work

PROJECT_TITLE: The Role of Salt-Inducible Kinases in Vitamin D Regulation and Mineral and Bone Metabolism Disorders

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Low-income populations have a disproportionately higher prevalence of type 2 diabetes and experience poorer health outcomes. This proposal will use the National Institute on Minority Health and Health Disparities research framework to develop a digital intervention tailored to the unique needs of low-income adults newly diagnosed with type 2 diabetes. We will also examine the feasibility and acceptability of implementing the intervention within a federally qualified health center and examine the effect on self-management behaviors and diabetes-related health outcomes.

PI_NAMEs: OWOLABI, EYITAYO OMOLARA (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Affect;American;Behavior;career;career networking;Cause of Death;Cellular Phone;Child Care;Clinical;Collaborations;Communication;Communities;cost;Development;Development Plans;Diabetes Mellitus;diabetes self-management;Diagnosis;Diet;digital;digital health;digital intervention;digital platform;Dimensions;Disparity;early onset;Education;efficacy testing;Electronic Mail;enhanced care;Enrollment;Ensure;Evidence based program;experience;feasibility trial;Federally Qualified Health Center;Focus Groups;Fostering;Funding;glycemic control;Glycosylated hemoglobin A;Goals;Growth;Health;Health behavior and outcomes;Health Care Costs;Health Disparities Research;health disparity;health equity;health equity promotion;Health Promotion;Healthcare Systems;High Prevalence;high risk population;High-Income Populations;improved;Individual;interest;Intervention;intervention effect;Interview;knowledge network;Letters;life span;Low income;Low Income Population;Measures;Mentorship;Methods;Morbidity - disease rate;mortality;Motivation;National Institute on Minority Health and Health Disparities;Nature;Neighborhood Health Center;Newly Diagnosed;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Ownership;patient population;patient portal;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Phase;Physical activity;pilot test;poor health outcome;Population;Premature Mortality;programs;Public Health;Qualifying;Quality of life;Randomized;randomized trial;Recommendation;recruit;Research;Research Support;Resources;Risk;satisfaction;Scientist;Self Management;Site;skills;social culture;System;Techniques;Technology;Telephone;Training;Transportation;treatment as usual;underserved community;Underserved Population;United States National Institutes of Health;uptake;Weight;Work

PROJECT_TITLE: SmartStart: A digitally-enhanced diabetes self-management intervention for low-income people newly diagnosed with type 2 diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (M2)]


PHR: PROJECT NARRATIVE: Precisely maintaining gene expression levels is essential to define cellular identity and to prevent a wide range of diseases, including developmental disorders and cancers. In mammalian cells, activation or repression of genes is accomplished in part by multiprotein complexes that affect local or higher-order chromatin structure. By understanding the molecular mechanism of the competition of activating and repressive complexes to determine gene expression levels this study will provide insights that may help guide the development of future therapeutics.

PI_NAMEs: NIEKAMP, STEFAN  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Address;Affect;Award;Biochemistry;Biological Assay;biophysical properties;Biophysics;California;career;Cells;Cellular biology;Chromatin;Chromatin Structure;Complex;Development;developmental disease;Disease;Dynein ATPase;Equilibrium;Event;Exclusion;experience;experimental study;Future;Gene Expression;Gene Expression Alteration;gene repression;General Hospitals;Genes;Genetic;Genetic Transcription;Genomic approach;Genomics;Health;Higher Order Chromatin Structure;imaging approach;In Vitro;insight;kinetic model;Laboratories;Learning;Link;Maintenance;Malignant Neoplasms;Mammalian Cell;Massachusetts;Mentors;Microscopy;Microtubules;Molecular;Molecular Biology;Molecular Conformation;Motor;Multiprotein Complexes;Mutation;Nucleosomes;Outcome;Pathway interactions;Phase;Physical condensation;Play;Polycomb;Postdoctoral Fellow;PRC1 Protein;prevent;Process;programs;Proteins;reconstitution;Regulation;Repression;Research;Research Personnel;Resolution;Role;San Francisco;Shapes;single molecule;skills;spatiotemporal;Structure;superresolution imaging;superresolution microscopy;System;Therapeutic;time use;Training;Transcriptional Regulation;Universities;Visualization;Work

PROJECT_TITLE: Unraveling the Dynamic Competition Between Activating and Repressive Complexes in Shaping Chromatin Accessibility


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

PHR: Project Narrative There are currently no validated measures of cognition that are sensitive to the range of functioning in individuals with profound intellectual disability (PID); however, these tools are critical for clinical care, person-centered services, and research contexts. This proposal seeks to develop novel performance (PerfO) and observer-report (ObsRO) measures of cognition that provide meaningful information about current functioning and have the potential to capture meaningful change in individuals with PID. The intent is that these measures will not only facilitate improved clinical care and services for individuals with PID but also support the development of novel treatments that will improve quality of life in this underserved group.

PI_NAMEs: LUDWIG, NATASHA  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Achievement;Advocate;Affect;Age;alertness;Attention;Auditory;Biological Markers;Brain Injuries;career development;Caregivers;Caring;Childhood;clinical care;clinical implementation;clinical outcome assessment;Clinical Services;clinical trial readiness;Clinical Trials;Cognition;Cognitive;cognitive function;Coma;Communication;Data;Dependence;design;Development;Development Plans;Disease;Education;efficacy evaluation;Environment;Equipment and supply inventories;Ethics;field study;Floor;Foundations;Future;Genetic Predisposition to Disease;Goals;Hand functions;Head;Impairment;improved;Individual;Intellectual functioning disability;International Classification of Diseases;Interview;Knowledge acquisition;Leadership;Learning;Literature;Measures;medical complication;Medical History;member;Mentorship;Methodology;Methods;Modeling;motor impairment;National Institute of Child Health and Human Development;Neurocognitive;non-verbal;novel;Outcome;Outcome Measure;Parents;Patients;Perception;Performance;performance tests;person centered;pilot test;Process;Property;Provider;Psychometrics;Quality of life;Recovery;remote administration;Reporting;Research;Research Priority;research study;Scientist;Self Care;Sensory impairment;Services;Severities;skill acquisition;skills;Standardization;Stimulus;success;Tactile;Testing;tool;Training;Training Activity;trait;Tube;Underserved Population;Validation;Visual;Wakefulness;Wheelchairs;Writing

PROJECT_TITLE: Measuring Responsivity in Individuals with Profound Intellectual Disability

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Many laboratory tests are unnecessary and contribute to reduced care quality. Using multisite data from the PICU Data Collaborative (PDC), we will develop machine learning models that forecast future laboratory values in children with critical illness, and identify processes to use these forecasts to reduce laboratory overutilization. We will use user-centered design principles to develop clinical decision support tool(s), deploy the tool(s) at a pilot site, and establish the groundwork for a future effectiveness-implementation trial.

PI_NAMEs: DZIORNY, ADAM C. (contact);SHAH, SAREEN S

PROGRAM_OFFICER_NAME: LOMOTAN, EDWIN A

PROJECT_TITLE: ML-ROVER: Machine Learning to Reduce Laboratory Test Overutilization

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Precision Medicine

PHR: PROJECT NARRATIVE. Molecular diagnostics (MDx) can provide personalized care and improve patient outcomes; however, disparities in payment for MDx create barriers that delay or prevent patients from accessing these diagnostic tests. The proposed project uses innovative mixed methods to address key gaps in our understanding of MDx payment disparities and identify strategies to promote access to MDx payment pathways. Results will lay the groundwork for developing policy and practice interventions that guide equitable MDx implementation.

PI_NAMEs: HAMMAD MRIG, EMILY A (contact)

PROGRAM_OFFICER_NAME: STERLING, RENE

PROJECT_TERMS: Academic Medical Centers;access disparities;Address;Agreement;Area;Cancer Patient;Caring;Case Study;Characteristics;Clinical;Complex;cost;Data;Diagnosis;Diagnostic tests;Disease;Disparity;disparity reduction;effectiveness evaluation;Electronic Health Record;Equity;Ethics;Ethnic Origin;Financial Support;Focus Groups;Foundations;Future;Goals;Group Interviews;Guidelines;health care settings;health disparity;Health Policy;Health Services Research;implementation framework;implementation science;improved;improved outcome;innovation;Institution;Insurance;Insurance Coverage;Integrated Health Care Systems;Interdisciplinary Study;Intervention;Interview;Knowledge;knowledge base;Link;Machine Learning;Malignant neoplasm of lung;maltreatment;Medical Genetics;meetings;Mentors;Methods;Molecular;Molecular Diagnostic Testing;molecular diagnostics;Natural Language Processing;Neighborhoods;Non-Small-Cell Lung Carcinoma;novel strategies;Outcome;Pathway interactions;patient navigator;Patient-Focused Outcomes;Patients;payment;personalized approach;personalized care;personalized medicine;Pilot Projects;Policies;Population;Population Heterogeneity;precision medicine;prevent;prior authorization;programs;Race;Recommendation;Research;Research Methodology;Resources;safety net;Shapes;skills;Statistical Data Interpretation;stem;Structure;Testing;Time;Training;Translating;tumor DNA;Underinsured;Variant;Work

PROJECT_TITLE: Promoting Access to Payment Pathways for Emerging Molecular Diagnostics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


NIH_SPENDING_CATS: Infectious Diseases;Neurosciences

ORG_CITY: IOWA CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Current mechanis.c studies of neuroimmune interac.ons are almost exclusively carried out with Speciﬁc Pathogen Free mice. In contrast, mice with “normalized” immune systems due to repeated microbial exposure demonstrate numerically enriched .ssue resident memory T cell (Trm) popula.ons in the brain. This proposal seeks to understand how these brain Trm interact and shape CNS myeloid cells at homeostasis and in neurological disease.

PI_NAMEs: HARTY, JOHN T (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Adult;Age;Aging;Animal Model;Antigens;Brain;brain shape;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cell Count;Cells;Central Nervous System Infections;Child;Choroid Plexus Epithelium;comparative;Data;Dendritic Cells;Detection;Disease;Epigenetic Process;Exhibits;experience;Exposure to;functional status;Generations;germ free condition;Goals;gray matter;Health;Homeostasis;Housing;Human;Immune;Immune response;Immune system;in vivo;Inbreeding;Infant;Infection;insight;intravital imaging;ITGAX gene;Knowledge;Laboratories;Literature;lymphoid organ;Memory;Meningeal lymphatic system;microbial;Microglia;Modeling;Motility;mouse model;Mus;Myelogenous;Myeloid Cells;Nerve Degeneration;Nervous System Disorder;Neuroanatomy;Neuroimmune;Neurological Models;Neurosciences Research;neurotropic;Organ;Outcome;Parabiosis;pathogen;pathogen exposure;Pathogenicity;Peripheral;Phenotype;Play;Population;Publishing;response;Role;Shapes;spatiotemporal;T memory cell;T-Lymphocyte;Techniques;tissue resident memory T cell;Tissues;transcriptomics;Traumatic Brain Injury;tumor;Umbilical Cord Blood;Visualization;white matter;young adult

PROJECT_TITLE: Brain T cell interactions in microbial experienced mice

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: SAINT LOUIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE Mycobacterium tuberculosis (Mtb) infection causes approximately 10 million new cases of tuberculosis (TB) and 1.5 million TB-related deaths each year, in addition to being the leading cause of death in HIV-infected individuals. In order to develop new and more effective therapies, better understanding of Mtb pathogenesis and HIV-TB co-infection is required. The proposed studies will provide critical insight into the pathogenesis of TB, the immune requirements for successful control of Mtb infection, and how HIV infection affects this control.

PI_NAMEs: BRYSON, BRYAN DAVID;MATTILA, JOSHUA T.;STALLINGS, CHRISTINA LEIGH (contact)

PROGRAM_OFFICER_NAME: RADKE, JOSHUA BRYAN

PROJECT_TERMS: Acute;Address;Affect;Alveolar Macrophages;Animal Model;Antimycobacterial Agents;Cause of Death;Cell Communication;Cell Culture System;Cells;Cessation of life;chemokine;co-infection;cytokine;Data;Development;Disease;effective therapy;Environment;Event;experimental study;extracellular;Granuloma;HIV;HIV Infections;HIV/TB;Hour;Immune;Immunity;improved;In Vitro;in vivo;Individual;Infection;Inflammatory Response;innovation;insight;Interferon Type I;Interferons;Interruption;Knowledge;Link;Macrophage;Molecular;Mycobacterium tuberculosis;Necrosis;neutrophil;Neutrophil Infiltration;Outcome;Pathogenesis;Pattern;Peripheral;Persons;pharmacologic;Predisposition;Process;programs;Public Health;recruit;response;Risk;Signal Transduction;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Tissues;Tuberculosis;Work

PROJECT_TITLE: Type I IFN-dependent and independent contributions to the outcomes of early innate immune cell interactions during HIV/TB co-infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 RCU-A (M1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Neonatal Respiratory Distress;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

PHR: PROJECT NARRATIVE The goal of this research is to examine and understand the transition to home after initial hospital discharge for Black preterm infants with chronic lung disease and to pilot a novel parent engagement intervention in pediatric primary care to reduce respiratory morbidity. Black preterm infants with chronic lung disease face a lifetime of disparities in lung health compared to White preterm infants, yet studies to date have primarily focused on infants' initial hospital stay and do not account for families' lived experiences at home that meaningfully shape child health and wellbeing. The K23 award will prepare the applicant for an independent research career with expertise in parent engagement interventions in primary care to advance health equity, while providing insights into early lung health for Black preterm infants with chronic lung disease.

PI_NAMEs: SMITH, BRANDON  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Area;asthma inhaler;Birth;Black race;Bronchopulmonary Dysplasia;career;career development;Caring;Child;Child Care;Child Health;Child Welfare;Childhood;Chronic Disease;Chronic lung disease;Collaborations;comorbidity;Complex;critical period;Data;data registry;design;Development;Development Plans;Diagnosis;Discrimination;Disparity;Diuretics;efficacy testing;Emergency department visit;Enteral Feeding;Environment;Equity;experience;Face;Family;follow-up;Fostering;Future;Goals;Guidelines;Health;health determinants;health disparity;health equity;health equity promotion;Health equity research;health goals;health inequalities;Healthcare;high risk;Home;hospital readmission;Hospitals;housing instability;improved;Infant;infant morbidity;insight;Institution;Intervention;Interview;Learning;Length of Stay;Life;Life Cycle Stages;Lived experience;lung health;Medical;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;method development;Morbidity - disease rate;multidisciplinary;National Heart, Lung, and Blood Institute;novel;Outcome;Outpatients;Parents;patient engagement;Patients;Pediatrics;peer;Personal Satisfaction;personalized care;Pharmaceutical Preparations;physical conditioning;Premature Birth;Premature Infant;Primary Care;primary care visit;Provider;pulmonary function;Qualitative Methods;Qualitative Research;Race;racial disparity;racism;randomized, clinical trials;Research;research and development;Research Personnel;respiratory morbidity;Respiratory Signs and Symptoms;Risk;Sampling;Self Management;Shapes;shared decision making;skill acquisition;skills;Smoke;social determinants;Statistical Methods;Statistical Models;Structure;supplemental oxygen;Testing;theories;therapy development;Time;tool;Training;United States;Voice;Well Child Visits;wellness visit;Wheezing;Work

PROJECT_TITLE: Addressing Racial Disparities in Chronic Lung Disease for Preterm Infants Through Parent Engagement

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (M3)]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cardiovascular;Clinical Research;Heart Disease;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE This project will study mechanisms of heart failure by analyzing images of the heart and proteins form the blood together. We will investigate two heart diseases with mechanisms of infiltration and toxicity: light-chain amyloid heart disease, and cancer-therapy-related heart disease. We aim to deepen our understanding of the mechanisms of these diseases, improve evaluation and prevention strategies for future patients, and identify new targets for drug development to improve outcomes of patients with heart failure.

PI_NAMEs: CLERC, OLIVIER FLORIAN (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Advisory Committees;Affect;American;Amyloid;Amyloid Fibrils;Amyloidosis;Anthracycline;Blood;Cardiac;Cardiac Myocytes;Cardiomyopathies;cell growth;chemotherapy;Clinical;clinical risk;Clone Cells;cohort;comparison group;Competence;Data;Data Science;Disease;drug development;Echocardiography;EFRAC;Evaluation;experience;extracellular;Fellowship;Functional disorder;Funding;Future;Goals;Heart;Heart Diseases;Heart failure;heart imaging;Image;Immunoglobulins;improved;improved outcome;Individual;Infiltration;Injury;innovation;insight;Light;Light-Chain Immunoglobulins;Magnetic Resonance Imaging;Measures;Methods;mortality;Multiple Myeloma;Myocardial;Myocardial dysfunction;new therapeutic target;novel;novel marker;outcome prediction;Participant;Pathogenesis;Pathogenicity;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Phase;Plasma;Plasma Cells;Plasma Proteins;Population;Positron-Emission Tomography;Prevention strategy;Proteins;Proteomics;proteostasis;radiotracer;Research;Research Personnel;Research Project Grants;risk stratification;Severities;skills;Toxic effect;Training;training project;Treatment-Related Cancer;Work;β-amyloid burden

PROJECT_TITLE: Elucidating Mechanisms of Cardiac Dysfunction Using Imaging and Proteomics

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (MA)]


NIH_SPENDING_CATS: Lung;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE: The nasal mucosa is the first site of contact of the inhaled air and its particulate matter including allergens and the respiratory tract. The olfactory neuroepithelium, embedded in the nasal mucosa, is a unique neuronal organ comprised of olfactory sensory neurons surrounded by specialized epithelial cells, two distinct populations of progenitor cells and interspersed immune cells. TRPM5+ microvillous cells are epithelial cells lining the surface of the olfactory epithelium. They are directly activated by allergens to generate potent pro- inflammatory mediators (lipid mediators, acetylcholine and IL-25) and orchestrate olfactory remodeling. The proposal here seeks to define how the TRPM5+ microvillous cells detect allergens and how these cells direct the spread of allergen-elicited activation signals in the olfactory epithelium.

PI_NAMEs: BANKOVA, LORA  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Acetylcholine;Afferent Neurons;Air;airborne allergen;airway epithelium;airway inflammation;Allergens;Allergic;Allergic Disease;allergic response;Alternaria;Anti-Inflammatory Agents;Apical;Asthma;Cell Line;cell type;Cells;Chronic;chronic rhinosinusitis;Coughing;cysteinyl-leukotriene;cytokine;Detection;Dinoprostone;Eicosanoids;Epithelial Cells;Epithelium;Event;Family;Fluorescence;Foundations;Generations;Goals;healing;Homeostasis;Human;Image;imaging system;Immune;In Vitro;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Inhalation;Ligands;lipid mediator;Maps;Mediator;member;Mucociliary Clearance;Mucous Membrane;Mus;neuroepithelium;Neurons;Nose;Olfactory Epithelial Cell;Olfactory Epithelium;Olfactory Mucosa;Olfactory Pathways;olfactory sensory neurons;Organ;Particulate Matter;Pathway interactions;Phenotype;Population;Positioning Attribute;programs;Prostaglandin D2;Prostaglandins;Publishing;receptor;Receptor Cell;respiratory;Respiratory Mucosa;Respiratory System;response;Role;sensor;Sensory;sensory system;Signal Induction;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Sneezing;Specialized Epithelial Cell;stem cell population;stem cell proliferation;stem cells;Stress;Structure of mucous membrane of nose;Succinates;Surface;synergism;System;Taste Buds;Taste Perception;Techniques;therapeutic target;Time;time use;tool;Trachea;TRPM5 gene;Work

PROJECT_TITLE: Allergen-elicited signaling cascades in olfactory microvillous tuft cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (57)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences

PHR: Project Narrative Upon successful completion of the proposed research, we expect our contribution to address the critical unmet need for longitudinal data from clinical outcome assessments and plasma biomarkers for clinical trial readiness for the rare disorder of Posterior Cortical Atrophy (PCA). This contribution will be significant because it will establish the essential foundation necessary to successfully design and recruit participants with PCA for future clinical trials with currently available candidate therapeutics. Longitudinal investigations of PCA will also allow us to broaden our understanding of the heterogeneous nature and pathophysiology of Alzheimer's disease, which is especially relevant to the development of new approaches to treatments for a major public health issue.

PI_NAMEs: PELAK, VICTORIA SUSAN (contact)

PROGRAM_OFFICER_NAME: CHEN, ALICE

PROJECT_TERMS: Address;Age;Age of Onset;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease therapeutic;Amyloid;Amyloid beta-Protein;Atrophic;Benchmarking;Biological Markers;Caring;Case Series;cerebral atrophy;Characteristics;Clinical;Clinical Data;clinical outcome assessment;clinical outcome measures;clinical trial readiness;Clinical Trials;Clinical Trials Design;clinically relevant;Cognitive;cognitive task;cognitive testing;Collaborations;college;Consensus;Data;Dementia;design;Development;Diagnosis;diagnostic criteria;Disease;Enrollment;Event;Exclusion;executive function;Foundations;Functional disorder;Future;Glial Fibrillary Acidic Protein;Goals;Impairment;inclusion criteria;informant;insight;International;Investigation;Judgment;Knowledge;Language;Lead;Light;London;Measurable;Measures;Memory;Methods;Modeling;Modification;Nature;Nerve Degeneration;neurofilament;novel;novel strategies;Outcome;Outcome Measure;Parietal;Participant;Pathology;Patient Recruitments;Patients;performance based measurement;Persons;Phenotype;Plasma;Positioning Attribute;predict clinical outcome;prospective;Public Health;Publishing;rare condition;Rare Diseases;Reporting;Research;Sample Size;Staging;Surrogate Markers;Syndrome;tau Proteins;therapeutic candidate;Time;Universities;Variant;Vision;Visual;visual dysfunction;Visual impairment

PROJECT_TITLE: Clinical Trial Readiness for Posterior Cortical Atrophy Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-3 (02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Patient Safety;Social Determinants of Health;Substance Misuse

ORG_DEPT: EMERGENCY MEDICINE

PHR: PROJECT NARRATIVE Over 2.7 million people suffer from opioid use disorder in the United States, resulting in more than 80,000 opioid overdose deaths in 2021. Medications for opioid use disorder are underused disproportionately in patients living in poverty, whose unmet food, housing, and transportation needs impede access to medications and routine healthcare. This proposal—which is aligned with the patient-centered models of care priority of the Services Research Branch at the National Institute of Drug Abuse—will leverage clinical decision support technology to incorporate social care into opioid use disorder medication treatment, with the goal of improving treatment adherence and follow up.

PI_NAMEs: MOLINA, MELANIE FRANCES (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Address;Adherence;Buprenorphine;California;career development;Caring;Chronic Disease;Clinical;clinical center;clinical decision support;Clinical Informatics;Clinical Sciences;Clinical Treatment;Clinical Trials;Collection;Community Medicine;COVID-19 pandemic;Data;Data Collection;data modeling;Databases;design;Diabetes Mellitus;Disease;Documentation;Electronic Health Record;Emergency Care;Emergency Department patient;Emergency Medicine;enhanced care;Epidemic;evidence base;experience;Family Practice;Feedback;Focus Groups;follow-up;Food;Goals;Group Meetings;Health;health care availability;health care service utilization;health information technology;Health Professional;Health Sciences;Health Services Research;Healthcare;Housing;human centered design;Hypertension;implementation intervention;implementation science;implementation strategy;improved;Individual;insight;Intervention;Interview;Journals;Link;Logic;Measures;medication for opioid use disorder;Medicine;meetings;Mentors;Mentorship;Metadata;Methodology;Methods;Modeling;multidisciplinary;National Institute of Drug Abuse;opioid mortality;opioid use disorder;Outcome;outcome disparities;outreach;Overdose;Patient Care;patient oriented;Patient Recruitments;Patients;Persons;Pharmaceutical Preparations;Pilot Projects;Population;Poverty;primary endpoint;Process;Professional Organizations;professor;prototype;Provider;Public Health;Quality of Care;Recommendation;Reporting;Research;Research Infrastructure;Research Personnel;Research Priority;Resources;response;Retrieval;Risk;Sampling;San Francisco;Services;skills;social;social disparities;social health determinants;social interventions;Social Workers;Structure;support tools;Surveys;Technology;Testing;Time;Training Activity;Translational Research;Transportation;treatment adherence;United States;Universities;usability;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Using Clinical Decision Support to Provide Social Risk-Informed Care for Opioid Use Disorder in the Emergency Department

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Neurosciences

ORG_CITY: MILWAUKEE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative Our work is designed to investigate the nociceptive roles of Piezo1 channels in the Schwann cells of the peripheral nervous system via adeno-associated virus (AAV)-mediated in vivo selective inhibition of Piezo1 in Schwan cells.

PI_NAMEs: YU, HONGWEI  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: adeno-associated viral vector;Agonist;Antibodies;Behavior;Biodistribution;Biological;Calcium;Capsid;Capsid Proteins;Cells;cellular transduction;Data;Dependovirus;design;Development;efficacy testing;efficacy validation;Evaluation;Experimental Designs;feasibility testing;Foundations;Functional disorder;Future;Gel;Genetic Transcription;Goals;Human;Hypersensitivity;Image;Immunohistochemistry;in vivo;inhibitor;Injections;Injury;innovation;knock-down;Label;Lumbar spinal cord structure;Maintenance;Mammals;mechanical force;Mechanics;Mediating;Modeling;Motor;motor behavior;nerve injury;Neurons;Nociception;novel;Organ;Pain;pain sensation;painful neuropathy;Pathology;Peptide aptamers;Peptides;Peripheral Nerves;Peripheral Nervous System;Physiological Processes;Physiology;Piezo 1 ion channel;Play;Production;promoter;Proteins;Rattus;response;Role;Rotarod Performance Test;Schwann Cells;sciatic nerve;Sensory;Silver Staining;Skin;small hairpin RNA;Spinal Ganglia;Structure of tibial nerve;System;Techniques;Testing;Transgenes;Tropism;Validation;Western Blotting;Work

PROJECT_TITLE: Schwann cell Piezo1 and pain sensation

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE Post-traumatic stress and alcohol use disorder (PTSD/AUD) are frequently comorbid and are a major public health problem. The proposed multidisciplinary research is relevant to the mission of NIAAA and addresses important gaps in the literature on examining the role of antistress neurocircuitry (somatostatin) underlying PTSD/AUD comorbidity and novel mechanistic strategies for their prevention and treatment.

PI_NAMEs: CRUZ, BRYAN  (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: addiction;Address;Affect;Aggressive behavior;Agonist;Alcohol consumption;alcohol exposure;alcohol relapse;alcohol risk;alcohol use disorder;Alcohols;Amygdaloid structure;Anti-Anxiety Agents;Anxiety;anxiety-like behavior;associated symptom;Award;Behavior Disorders;Behavioral;behavioral pharmacology;behavioral phenotyping;Brain;Brain region;career development;cell type;Cells;comorbidity;Complement;Complex;confocal imaging;Corticosterone;Corticotropin-Releasing Hormone;COVID-19 pandemic;Data;designer receptors exclusively activated by designer drugs;Development;Diagnosis;Disease;drinking;Electrophysiology (science);Feeling suicidal;Female;Gene Transfer;Genetic;Goals;Health;Heavy Drinking;High Prevalence;In Situ Hybridization;Individual;Infusion procedures;insight;interdisciplinary approach;Interdisciplinary Study;Investigation;Knockout Mice;Label;Lateral;Literature;male;Mentors;Methods;Mission;Modeling;Molecular;National Institute on Alcohol Abuse and Alcoholism;Nature;negative emotional state;neural circuit;Neurons;Neuropeptides;neurophysiology;Neurosciences;novel;novel therapeutic intervention;novel therapeutics;overexpression;Peptides;pharmacologic;Phase;Phenotype;post-traumatic stress;Post-Traumatic Stress Disorders;prevent;Prevention;programs;Property;Prosencephalon;Public Health;rapid growth;Rattus;receptor;Recording of previous events;Reduce health disparities;Regulation;Research;Risk;RNA;Rodent;Rodent Model;Role;sex;Sex Differences;sexual dimorphism;Signal Transduction;Site;Sleep disturbances;Slice;Somatostatin;Somatostatin Receptor;Stress;stress disorder;stress related disorder;Structure;Structure of terminal stria nuclei of preoptic region;suicide rate;Symptoms;Synapses;synaptic function;System;Testing;therapeutic candidate;Therapeutic Uses;Training;Violence;Viral;Viral Genes;Vulnerable Populations;Work

PROJECT_TITLE: Extended amygdala somatostatin role in post-traumatic stress and alcohol use disorder

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE Breakthroughs in cancer immunotherapy have paved the way in leveraging the immune system to combat highly aggressive malignancies. The overall goal of this proposal is to develop microbial-based agents that increase immune density within immunologically “cold” tumors as a means to enhance efficacy and response rates to current immunotherapies. If successful, these microbial-based agents, termed “bio-beacons,” will significantly impact patient outcomes and overall survival worldwide.

PI_NAMEs: MANUEL, EDWIN  (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: Achievement;Address;Antineoplastic Agents;Antitumor Response;bacterial vector;Biological;cancer immunotherapy;cancer therapy;CAR T cell therapy;CCL3 gene;CCL4 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Density;cell killing;Cell Line;Cell Therapy;cell type;Cells;cellular transduction;checkpoint inhibition;chemokine;chemotherapy;Chimeric Proteins;clinical development;clinical translation;combat;combinatorial;cost effective treatment;CTLA4 gene;cytokine;cytotoxic CD8 T cells;Defect;Dendritic Cells;density;Development;efficacy evaluation;Engineering;Escherichia coli;Evaluation;Exclusion;experimental study;FDA approved;Frequencies;Future;Goals;Image;Immune;immune cell infiltrate;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;Immunologics;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;Infiltration;interest;Interleukin-15;Laboratories;Ligands;Lymphocyte;Malignant - descriptor;Malignant Neoplasms;Mediating;microbial;migration;Migration Assay;Modeling;Monoclonal Antibodies;monocyte;Mus;National Cancer Institute;Natural Killer Cells;neoplastic cell;novel;patient response;Patient-Focused Outcomes;Patients;Peptide Hydrolases;Peptide Signal Sequences;periplasm;Phenotype;programmed cell death protein 1;Progression-Free Survivals;Proliferating;Protein Precursors;Protein Secretion;Quality of life;receptor;recruit;response;Series;Signal Transduction;Solid;Solid Neoplasm;Specificity;Splenocyte;synergism;System;T cell infiltration;T-Cell Activation;T-Lymphocyte;Therapeutic;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-infiltrating immune cells;Type II Secretion System Pathway;vector

PROJECT_TITLE: Modulating Intratumoral Immune Composition to Enhance Immunotherapy

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Social deficits in autism spectrum disorder may partially reflect blunted reward response to social stimuli. Although neuroimaging research suggests this blunting may generalize beyond the social domain, most studies fail to directly compare neural response to social and non-social outcomes and no study models the experience of actually being liked by peers (i.e., direct social reward). We propose to overcome these shortcomings by isolating differences in neurotypical and autistic adolescents’ neural response to social (being liked) and non- social (winning money) reward using fMRI, and for the first time, midbrain dopamine system function, with neuromelanin-sensitive MRI.

PI_NAMEs: JARCHO, JOHANNA MOLLY (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Address;Adolescence;adolescent with autism spectrum disorder;Age;Animal Model;applied behavior analysis;autism spectrum disorder;autism symptoms;autistic;Award;Behavior;Brain;Characteristics;Corpus striatum structure;Data;Development;Dimensions;Dopamine;dopamine system;Exhibits;experience;Face;Feedback;Female;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Heterogeneity;Human;individualized medicine;information processing;innovation;Intervention;Knowledge;Link;Magnetic Resonance Imaging;Measures;Methods;Midbrain structure;model of autism spectrum disorder;Modeling;Motivation;multimodal neuroimaging;neural;neural correlate;Neurocognitive;neuroimaging;neuromechanism;neuromelanin;novel;novel strategies;Outcome;peer;Persons;pharmacologic;Pharmacological Treatment;Phase;Positioning Attribute;Positron-Emission Tomography;Prevalence;Proxy;Psychological reinforcement;Punishment;Radioactivity;reinforcer;repetitive behavior;Research;Research Design;Resources;response;reward dysfunction;reward processing;Rewards;Sex Differences;Signal Transduction;Smiling;social;social communication;social deficits;Social Problems;Stimulus;Study models;substance use;Symptoms;System;Techniques;Testing;Time;Treatment Efficacy;Treatment outcome;Variant;Work;Youth

PROJECT_TITLE: Neural mechanism of reward processing in autistic adolescents

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Public Health Relevance/Narrative Chemical imaging holds tremendous promise in intraoperative cancer diagnosis and personalized drug screening. However, the inherent tradeoff between resolution and field of view is a major challenge to its various biomedical applications. We will develop new deep-learning algorithms to break the tradeoff and enable large- area, high-resolution chemical imaging of any biological samples.

PI_NAMEs: FU, DAN  (contact);WANG, SHENG

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: 3-Dimensional;absorption;Address;Adoption;Area;Artificial Intelligence;Automobile Driving;Benchmarking;Biological;biomedical imaging;brain tissue;Cancer Detection;cancer diagnosis;Cancerous;Cell Count;Cells;Chemicals;Chromatin Structure;clinical application;computerized tools;contrast imaging;convolutional neural network;Data;Data Set;deep learning;deep learning algorithm;Diagnosis;Diffusion;Dimensions;Drug Delivery Systems;drug discovery;Drug Screening;European;Exclusion;Feedback;Fluorescence;Fluorescence Microscopy;Foundations;generative adversarial network;generative models;Goals;Hi-C;high resolution imaging;Histology;Image;image reconstruction;imaging modality;Imaging Techniques;improved;innovation;instrumentation;interest;Label;large datasets;Lasers;Lateral;Learning;lipid metabolism;live cell imaging;Marketing;Methodology;Methods;Microscope;microscopic imaging;Microscopy;Modeling;Molecular;molecular imaging;multiplexed imaging;Mus;network models;Network-based;neurosurgery;novel;Operative Surgical Procedures;Organelles;particle;Pathology;Patient-Focused Outcomes;Performance;Pharmaceutical Preparations;precision drugs;Process;public health relevance;Research;Resolution;Risk Reduction;Sampling;single cell analysis;Speed;Stains;Structure;Subcellular structure;submicron;superresolution microscopy;Surgeon;System;Techniques;Testing;Texture;Three-Dimensional Image;Time;Tissue imaging;tissue processing;Tissue Sample;Tissues;tool;Training;training data;Transcend;Translating;ultra high resolution;vibration;Visualization;Work

PROJECT_TITLE: Super-resolution chemical imaging via a diffusion-based deep generative model

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Endocrine Disruptors;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: SAN DIEGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Maternal exposure to the environmental contaminant trichloroethylene (TCE) is associated with elevated risk of small-for-gestational-age (SGA), an adverse birth outcome that increases the risk for morbidity and mortality in infancy and chronic metabolic diseases in adulthood. This Transition to Independent Environmental Health Research (TIEHR) Career Award will provide training and research support to investigate the biological plausibility of TCE contributing to elevated risk of SGA by identifying molecular mechanisms underpinning disruption of placental cellular function at the maternal-fetal interface. The results of this research will offer valuable insights for policymakers and clinicians, helping enhance protective measures and therapeutic strategies to improve maternal and fetal health outcomes.

PI_NAMEs: ELKIN, ELANA  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Abbreviations;Adult;adverse birth outcomes;adverse pregnancy outcome;Affect;Apoptosis;Award;Biological;Biological Process;career;cell injury;Cell Line;Cell Nucleus;Cell Physiology;cell type;Cells;Cellular Structures;Chronic;Circulation;combat;Communication;Complex;Cysteine;cytotrophoblast;Data;Decidua Basalis;Development;disorder risk;Electron Transport;Ensure;Environmental Health;Environmental Pollutants;experience;Exposure to;fetal;Fetal Development;Fetal Growth Retardation;Fetal health;Fetus;fluorescein isothiocyanate dextran;Functional disorder;Gene Expression;Genus Hippocampus;Glucose;Glutathione;Goals;Health;Health Care Research;high resolution imaging;Human;Impairment;improved;In Vitro;in vitro Model;Indomethacin;Industrialization;infancy;Inflammation;inhibitor;insight;Invaded;Life;Link;Low Birth Weight Infant;Maternal Exposure;Maternal Health;Maternal-Fetal Exchange;Measures;Mediating;Membrane;Membrane Potentials;Mentors;Metabolic Diseases;Methods;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Modeling;Molecular;monolayer;Morbidity - disease rate;Morphology;mortality;National Institute of Environmental Health Sciences;Nature;novel;Nutrient;Organ;Outcome;Oxidative Stress;Oxygen Consumption;Pathway interactions;Placenta;placental trophoblasts;Play;Policy Maker;Population;Porosity;prevent;Publishing;Rattus;Regulation;Regulatory Pathway;reproductive;Research;research and development;Research Personnel;Research Support;response;Risk;Role;Science;Scientific Advances and Accomplishments;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;skills;Small for Gestational Age Infant;Solvents;Spiral Artery of the Endometrium;Syncytiotrophoblast;Technology;Testing;Therapeutic;Therapeutic Intervention;Time;time use;Toxic effect;toxicant;Toxicant exposure;Toxicology;Training;Training Support;Transport Process;Trichloroethylene;trophoblast;Uterus;Villous;Visual;Work;Xenobiotics

PROJECT_TITLE: Toxic effects of trichloroethylene and its metabolite on placental cells at the maternal-fetal interface

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 BWD-S (99)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Chimeric antigen receptor (CAR) T cell therapies have revolutionized treatment options for patients with hematologic malignancies and hold promise for other types of cancer. However, limited CAR T cell expansion, persistence, and immune suppression from T regulatory (Treg) cells limit efficacy of CAR T cell therapies for large B cell lymphoma (LBCL). This proposal will: (1) employ fate mapping to identify drivers of desirable T cell states in pre-manufacture apheresis and infusion products with optimal expansion and persistence properties, and (2) mechanistically dissect and evaluate methods to overcome Treg suppression, providing a platform to improve CAR T cell therapy treatment options for patients with cancer.

PI_NAMEs: GOOD, ZINAIDA  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Advisory Committees;Affect;Atlases;Autologous;Award;B-Cell Leukemia;B-Cell Lymphomas;Back;Bar Codes;Biological Models;Biopsy;Blood;Blood Component Removal;cancer cell;Cancer Center;cancer immunotherapy;cancer type;CAR T cell therapy;career;career development;CD19 gene;CD22 gene;Cell Lineage;Cell Therapy;Cells;Cellular biology;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Trials;Clonal Expansion;Clone Cells;Companions;cytokine;Data;Data Set;demethylation;design;Disease;Disease remission;disorder control;engineered T cells;Engineering;Ensure;experience;Foundations;FOXP3 gene;Funding;Gene Expression;gene regulatory network;Goals;Grant;Hematologic Neoplasms;high risk;Home;Homing;Human;human model;Hybrids;IL7 gene;immunodeficient mouse model;Immunology;Immunooncology;Immunosuppression;Immunotherapy;improved;improved outcome;In complete remission;in vitro Assay;in vivo;Individual;Infusion procedures;insight;Interleukin-15;Interleukin-2;Knock-out;Large-Cell Lymphomas;Learning;leukemia/lymphoma;Link;Lymphoma;Malignant Neoplasms;manufacture;Maps;Mediating;Medicine;Membrane Proteins;Mentors;Mentorship;Methods;Methylation;Molecular;Nature;next generation;Oncology;Pathway Analysis;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Pre-Clinical Model;prevent;Program Development;programs;Proliferating;Property;Public Health;Publications;Regulatory T-Lymphocyte;Research;research clinical testing;resistance mechanism;routine therapy;Scientist;single cell sequencing;skills;Solid Neoplasm;Sorting;standard of care;Stress;Structure;success;Systems Biology;T cell response;T cell therapy;T-Cell Development;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Time;time use;Training;transcription factor;transcriptome sequencing;tumor;United States Food and Drug Administration;Vision;Work

PROJECT_TITLE: Learning features of optimal CAR T cells for LBCL from patient data

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Heart Disease;Hematology;Hodgkin's Disease;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Prevention;Radiation Oncology;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE The majority of patients with nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) receive treatment with intensive chemotherapy with or without radiotherapy yet are at very low risk of lymphoma-specific death and are subsequently at risk for potentially fatal cardiotoxicity. We propose to identify cell state ecosystems predictive of clinical outcome, establish novel methods to genotype NLPHL, and quantify inherited risk of cardiovascular disease with the goal to inform a risk-adapted approach to management. This project will fuel the development of prospective clinical trials evaluating rational selection of patients suitable for de-escalation of therapy to optimize treatment for NLPHL and reduce therapy associated deaths.

PI_NAMEs: BINKLEY, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: active method;Address;Aftercare;B-Cell Lymphomas;Bioinformatics;Biological Assay;biomarker identification;Biometry;Biopsy;Blood specimen;Cancer Biology;Cardiotoxicity;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;career;career development;cell transformation;cell type;Cells;Cessation of life;chemotherapy;Chemotherapy and/or radiation;Clinical;Clinical Protocols;Clinical Trials;clinically actionable;Coronary Arteriosclerosis;Custom;Data;data management;design;Development;Development Plans;Diagnosis;Diagnostic;Disease;disorder risk;Doctor of Philosophy;Ecosystem;experience;Follicular Lymphoma;Foundations;Future;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genetic Risk;genomic biomarker;Genomics;Genotype;genotyped patients;Goals;Hematologic Neoplasms;high risk;Hodgkin Disease;Human;Hybrids;Immune;improved;Inherited;K-Series Research Career Programs;Knowledge;Large-Cell Lymphomas;liquid biopsy;Lymphocyte;Lymphoma;Malignant - descriptor;malignant lymphocyte;Measurable;Measures;medical schools;Mentorship;Methods;Morbidity - disease rate;mortality;Mutate;Mutation;novel;Outcome;outcome prediction;Patient Selection;Patients;personalized approach;personalized medicine;Phenotype;Plasma;predict clinical outcome;Predictive Factor;predictive modeling;professor;prognostic;Prognostic Marker;prognostic value;programs;progression risk;Progression-Free Survivals;prospective;protein biomarkers;Race;Radiation Oncology;Radiation therapy;Rare Diseases;Recurrence;Regulation;Relapse;Research;Risk;risk variant;Sampling;Selection for Treatments;single-cell RNA sequencing;Somatic Cell;standard care;statistics;surveillance strategy;symposium;targeted sequencing;Testing;Tissues;tool;Toxic effect;Training;transcriptome;transcriptome sequencing;transcriptomics;translational research program;treatment optimization;tumor;Tumor Burden;tumor DNA;tumor immunology;Universities;working group

PROJECT_TITLE: Investigating personalized approaches to de-intensify therapy for nodular lymphocyte-predominant Hodgkin lymphoma

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: Veteran suicides, suicide attempts and suicidal ideation continue to be major public health concerns. This research addresses two critical unmet needs related to suicidal behavior among veterans: 1) The unmet need for a rapid-acting treatment for veterans who are experiencing suicidal thoughts; and 2) The unmet need for valid objective measurements, or biomarkers of veteran suicidality, to improve diagnosis and guide treatment development. Through pilot testing the novel anti-suicidal treatment uridine, while pairing it with brain scans performed before-and-after treatment, the goal of this study is to improve our understanding of suicidal ideation in the veteran population.

PI_NAMEs: KONDO, DOUGLAS GAVIN (contact)

PROJECT_TERMS: abuse liability;active method;Acute;addiction;Address;Advocate;Aftercare;Amino Acids;Anabolism;Anesthesia procedures;antidepressant effect;Anxiety;Biological Markers;biomarker identification;biosignature;Brain;Brain imaging;Brain scan;Brain-Derived Neurotrophic Factor;Clinical;clinical biomarkers;clinical center;combat veteran;Congresses;Controlled Clinical Trials;Data;Delirium;Development;Diagnosis;Double-Blind Method;dysphoria;Education;Effectiveness;evidence base;experience;Feeling suicidal;FRAP1 gene;gamma-Aminobutyric Acid;gastrointestinal;Genes;Genitourinary system;Glutamine;Goals;Human;imaging biomarker;improved;in vivo;insight;Intervention;Intravenous;Intravenous infusion procedures;Investigation;Investigational Drugs;Ketamine;Literature;Lithium;Magnetic Resonance Spectroscopy;man;Manic;Measurement;Measures;Mental disorders;Mental Health Services;Methodology;Military Personnel;military veteran;Mission;Multienzyme Complexes;National Institute of Mental Health;neural;neurochemistry;neuroimaging;neurotransmission;novel;Odds Ratio;open label;Oral;Oral Administration;Participant;Pathogenesis;Pathway interactions;Patient Compliance;Patients;Pharmaceutical Preparations;Phase;Phencyclidine;Phosphorylation;pilot test;Placebo Control;Placebos;Post-Traumatic Stress Disorders;Probability;Prodrugs;Property;Protocols documentation;Protons;Psychoses;Public Health;Publications;Pyrimidine;Randomized;reducing suicide;Reporting;Research;Research Domain Criteria;response;Risk;Role;satisfaction;Scanning;Science;Severities;Soldier;spectroscopic imaging;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide brain;Suicide prevention;suicide substrates;suicide victim;Surveys;Symptoms;Testing;therapy development;tool;Toxic effect;translational study;Traumatic Brain Injury;treatment response;tripolyphosphate;United States Department of Veterans Affairs;Uridine;Veterans;Veterans Health Administration;Visit

PROJECT_TITLE: Clinical and Imaging Biomarker Trial of Uridine for Veterans with Suicidal Ideation

STUDY_SECTION: MHBB

STUDY_SECTION_NAME: Mental Health and Behavioral Science B[MHBB]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

PHR: Project Narrative Antibiotic resistance is a pressing, multifaceted challenge, and understanding it requires combining molecular, evolutionary, and structural frameworks. We will investigate how important but understudied types of mutations, specifically insertions and deletions, can radically change the properties of proteins responsible for resistance. Integrating our results will produce a deeper understanding of how microbes evolve, how proteins change, and what resistance might occur in the future.

PI_NAMEs: MACDONALD, CHRISTIAN BERNARD (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Acetylation;Amino Acids;analog;Antibiotic Resistance;Antibiotics;antimicrobial;Area;Binding;Biochemistry;Biological Assay;biophysical model;biophysical properties;Biophysics;Black Box;Chemosensitization;Clinical;Collaborations;combinatorial;Complex;Coupled;Coyotes;Crystallography;Development;Drug Design;Drug resistance;Enterococcus faecium;Environment;Enzymatic Biochemistry;enzyme activity;Escherichia coli;Event;Evolution;Failure;Family;fitness;Future;gain of function;Genes;Genetic Recombination;global health;Goals;Grant;Heterogeneity;Homologous Gene;improved;In Vitro;insertion/deletion mutation;insight;Laboratories;Libraries;Link;Longevity;Maps;Measurement;Measures;Mediating;Mentorship;Microbe;microbial;Modeling;Molecular;Molecular Conformation;mutant;Mutation;mutation screening;Nature;novel;novel strategies;Outcome;pathogen;Pathway interactions;permissiveness;Phenotype;Phylogenetic Analysis;Play;Positioning Attribute;predictive modeling;preempt;Process;Property;protein function;protein structure;Proteins;Research;Resistance;resistance gene;resistance mechanism;Resources;response;Ribosomes;Role;Sampling;Scanning;screening;Sequence Analysis;Streptogramins;Streptomyces;Structural Biochemistry;Structure;Substrate Specificity;Techniques;Temperature;training opportunity;Universities;Variant;Work

PROJECT_TITLE: Connecting structure and fitness landscapes to overcome antibiotic resistance


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Digestive Diseases;Genetics;Human Genome;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Defects in development that effect the migration of neural progenitor cells in the intestine can result in patient phenotypes, including Hirschsprung’s disease. Because the biological mechanisms behind this process are still not fully understood, we propose studying a key upstream regulatory gene Sox10 in the context of chromatin alterations, since it has been previously described as affecting chromatin in other neural crest derived cell populations. The findings from these proposed aims will advance knowledge of the molecular mechanisms of the development of the enteric nervous system which may be targets for study in human enteric nervous system- related disorders.

PI_NAMEs: BENTHAL, JOSEPH T (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Adult;Affect;Alleles;Animal Model;Animals;Antibodies;Architecture;ATAC-seq;Binding;Biological;Biological Assay;Candidate Disease Gene;Cell Fate Control;Cell Lineage;Cell Therapy;Cells;Chromatin;chromatin modification;chromatin remodeling;Chromatin Remodeling Factor;Chronic;Cleavage Under Targets and Release Using Nuclease;Colon;Complex;Congenital Megacolon;CRISPR interference;Data;Data Set;Defect;Development;developmental disease;developmental genetics;Developmental Process;directed differentiation;Disease;disease phenotype;Distal;DNA;DNA Binding;Elements;Enhancers;Enteral;Enteric Nervous System;enteric neuropathy;Epigenetic Process;Equilibrium;Excision;Exhibits;experience;experimental study;fetal;Fluorescence-Activated Cell Sorting;Ganglia;Gastroesophageal reflux disease;Gastrointestinal Motility;Gastrointestinal tract structure;Gene Expression;gene regulatory network;Genes;genetic architecture;genome-wide;genomic platform;Genomic Segment;Genomics;Genotype;histone methylation;histone modification;Human;In Vitro;Intestinal Motility;Intestines;Knowledge;Learning;Length;Link;Malignant Neoplasms;Maps;Mediating;migration;Modeling;Molecular;motility disorder;mouse model;multiple omics;Mus;mutant;Mutation;nerve stem cell;nervous system development;Neural Crest;Neural Crest Cell;neurogenesis;Neuroglia;Neuronal Differentiation;Neurons;Normal Range;Obstruction;Patients;Penetrance;Phenotype;Population;postnatal;Process;promoter;Protein Isoforms;Proteins;Regulation;Regulator Genes;Regulatory Element;Resolution;Role;single nucleus RNA-sequencing;stem cell differentiation;success;Testing;Tissue-Specific Gene Expression;Tissues;transcription factor;transcriptome sequencing;Variant;Work

PROJECT_TITLE: Assessing Sox 10's effect on chromatin accessibility in enteric neuron lineage diversification

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Clinical Research;Diabetes;Obesity

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE The proposed research aims to reveal (I) the dynamics of intermuscular adipose (IMAT) pro-inflammatory secretome across the BMI and insulin sensitivity spectrum and (II) the relative contribution of MAPK signaling to IMAT-induced muscle insulin resistance. This is relevant to public health because IMAT is physically positioned to exert profound metabolic consequences on skeletal muscle. Our findings will align with the NIH mission by enabling targeted IMAT therapies to robustly sensitize muscle to insulin, thus enhancing health, lengthening life, and reducing disability.

PI_NAMEs: MCKENNA, COLLEEN  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Adipose tissue;Bathing;Biological Assay;Biometry;Body mass index;Cardiometabolic Disease;cardiometabolic risk;Clinical;Clinical Sciences;Colorado;cytokine;Data;diabetes risk;disability;Endocrine;Endocrinology;Fascia;Funding;Goals;Health;Human;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Response;Institution;Insulin;Insulin Resistance;insulin sensitivity;insulin signaling;Intervention;Investigation;knock-down;Knowledge;Life;MAPK8 gene;Measures;Mediating;Medical;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic phenotype;Metabolism;Methods;Mission;Mitogen-Activated Protein Kinases;Muscle;Muscle Fibers;N-terminal;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Obesity;Obesity associated disease;Outcome;p38 Mitogen Activated Protein Kinase;paracrine;Paracrine Communication;Parents;Pathology;pharmacologic;Phenotype;Phosphotransferases;Positioning Attribute;Postdoctoral Fellow;Prediabetes syndrome;Proteins;Proteomics;Public Health;Research;Role;Severities;Signal Transduction;Skeletal Muscle;skeletal muscle metabolism;skills;Small Interfering RNA;subcutaneous;Testing;Thinness;Tissue Donors;Tissue Therapy;Training;transcriptome;Translational Research;translational scientist;United States National Institutes of Health;Universities;vastus lateralis;Viral;Visceral;Work

PROJECT_TITLE: The Role of IMAT Inflammatory Secretome on Muscle Insulin Resistance


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Microbiome;Nutrition

ORG_CITY: MADISON

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE  Non-alcoholic fatty liver disease (NAFLD) and Nonalcoholic steatohepatitis (NASH) are associated with gut dysbiosis and high dietary cholesterol intake and they affect a quarter of the world population, yet there are no FDA-approved treatments. This proposal aims to determine the mechanistic contribution of dietary cholesterol to NAFLD/NASH through actions of gut microbiota. Uncovering this aspect of NAFLD/NASH pathophysiology may lead to implementation of dietary and/or probiotic treatments to alleviate the burden of NAFLD/NASH worldwide.

PI_NAMEs: HERMANSON, JAKE BRENNER (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Affect;Alkynes;Animal Model;Automobile Driving;beneficial microorganism;Bifidobacterium;Bile Acids;Bioinformatics;Biological Assay;candidate identification;career;Chemistry;Cholesterol;Clinical Trials;Colony-forming units;Communication;Communities;Complex;cost;Coupled;Critical Thinking;Cues;Data;density;Development;Diet;dietary;Dietary Cholesterol;Dietary Component;Disease;Disease Outcome;Dose;Dyes;dysbiosis;Elements;Environment;epidemiology study;Exhibits;Extinction;Fatty acid glycerol esters;Fatty Liver;FDA approved;Feces;feeding;Fibrosis;fitness;Flow Cytometry;Fluorescence;Functional disorder;Gallbladder;gene function;Genes;Genomics;germ free condition;Germ-Free;Goals;Growth;gut dysbiosis;gut microbes;gut microbiome;gut microbiota;Healthcare;Hepatic;host-microbe interactions;improved;In Vitro;in vivo;Incidence;Individual;Inflammatory;insight;Institution;Intake;Intervention;Knowledge;Libraries;Life Style;liquid chromatography mass spectrometry;Liver;Liver Cirrhosis;Liver Dysfunction;Liver Fibrosis;liver injury;liver transplantation;loss of function;Massive Parallel Sequencing;Measures;Mediating;member;Membrane;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;metagenomic sequencing;Microbe;microbial;microbial community;Microbiology;microbiome research;microbiome therapeutics;microbiota;Molecular;mortality risk;Mus;Mutagenesis;mutant;Mutation;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel therapeutics;Onset of illness;Optics;Oral;Organism;Outcome;Pathogenesis;Persons;Population;Prevalence;prevent;Primary carcinoma of the liver cells;Principal Investigator;probiotic therapy;Proliferating;Role;rRNA Genes;saturated fat;Shotguns;skills;Small Intestines;sugar;Techniques;Testing;Time;Training;uptake;western diet;Writing

PROJECT_TITLE: The role of dietary cholesterol in Nonalcoholic fatty liver disease through the action of gut microbiota


NIH_SPENDING_CATS: Digestive Diseases;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: BIOLOGY

PHR: Project Narrative While ADAM17 loss of function mutations result in a highly fatal pediatric enteropathy presenting with chronic diarrhea and altered intestinal architecture, exceedingly little is known about the disease. This project aims to characterize the human intestinal phenotype caused by ADAM17 loss of function, determine if ADAM17 proteolytic activity mediates cell signaling crosstalk, and define all ADAM17 substrates in the developing human intestine. This work will provide insight on the role of ADAM17 in the developing human intestine by characterizing cellular and molecular changes caused by ADAM17 loss of function in a patient specific iPSC- derived human intestinal organoid model.

PI_NAMEs: WILLIAMS, SHANE  (contact)

PROJECT_TERMS: Architecture;Binding;Biological Assay;Biological Models;Biopsy;Cell Differentiation process;Cell Maturation;Cell Membrane Proteins;Cell Separation;cell type;Cells;Childhood;Chronic diarrhea;CRISPR correction;Data Set;Development;Diarrhea;directed differentiation;Disease;disease model;Disintegrins;EGF gene;Environment;Epithelial Cells;Epithelium;Family;fetal;Fetal Development;Future;Genetic Transcription;gut inflammation;Homeostasis;Human;human disease;Immunofluorescence Immunologic;Impairment;improved;In Vitro;induced pluripotent stem cell;infancy;Inflammatory;innovation;insight;intestinal crypt;intestinal epithelium;Intestines;Investigation;Knockout Mice;Ligands;loss of function;loss of function mutation;Mass Spectrum Analysis;Mediating;Membrane;Mesenchymal;Mesenchyme;Metalloproteases;Modeling;Molecular;Morphogenesis;Morphology;mutation correction;Neonatal;Neuregulin 1;Organoids;Pathway interactions;Patients;Pattern;Peptide Hydrolases;Permeability;Phenotype;Proteins;Proteomics;receptor;Receptor Activation;Role;Sampling;Signal Transduction;Signaling Molecule;skin disorder;Specialized Epithelial Cell;stem cell niche;stem cells;Structure;Study models;Supporting Cell;Testing;Tissues;transcriptome sequencing;transcriptomics;Villus;Work

PROJECT_TITLE: Investigating a rare pediatric enteropathy caused by ADAM17 loss of function using iPSC-derived human intestinal organoids


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: NARRATIVE High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) is a non-invasive method for clinical brain stimulation that can treat psychiatric disorders. HF-rTMS is thought to restore excitability in hypoactive circuits, but the mechanisms underlying the therapeutic effects of rTMS remain poorly understood. This project will determine how focal HF-rTMS induces plasticity in cortical circuits and whether particular classes of neurons underlie the behavioral effects of rTMS, leading to improved design of clinical treatments.

PI_NAMEs: GONGWER, MICHAEL W. (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Address;Affect;Anhedonia;Animal Model;Attenuated;Behavior;Behavioral;Behavioral Assay;behavioral outcome;Brain;Brain region;Chronic;Chronic stress;Clinical;clinical effect;Clinical Treatment;Collaborations;coping;Coping Behavior;Coping Skills;Corpus striatum structure;Dendritic Spines;density;design;Disease;effective intervention;excitatory neuron;Excitatory Synapse;experience;Face;FDA approved;forced swim test;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Genetic;genetic approach;genetic manipulation;Hippocampus;Human;improved;improved outcome;in vivo;Individual;insight;Label;Left;Long-Term Potentiation;Major Depressive Disorder;maladaptive behavior;Measurement;Mediating;Mental Depression;Mental disorders;Methods;Midbrain structure;Miniaturization;Motor;Mus;Neocortex;Nervous System Disorder;Neurons;neuropsychiatric disorder;Neurosciences;novel;Obsessive-Compulsive Disorder;Outcome;Patients;Pilot Projects;Play;Prefrontal Cortex;Protocols documentation;Pyramidal Tracts;rational design;repetitive transcranial magnetic stimulation;Research;Rewards;Risk Factors;Rodent;Rodent Model;Role;Site;Stress;stress reduction;Synapses;Synaptic plasticity;System;Testing;Thalamic structure;Therapeutic Effect;tool;Treatment Protocols;United States National Institutes of Health;Vertebral column;virus genetics;Work

PROJECT_TITLE: Investigating circuit-specific effects of high-frequency repetitive transcranial magnetic stimulation


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Neurosciences;Pain Research;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Several lines of research indicate that adolescent alcohol misuse is associated with increased pain sensitivity in adults. The biological basis for this increase is presently not fully understood. This project seeks to determine the role of adolescent alcohol exposure induced changes within an amygdala to prefrontal cortex to periaqueductal gray circuit involved in pain processing on pain sensitivity in adulthood.

PI_NAMEs: OBRAY, JAMES DANIEL (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Acute;Acute Pain;Adolescence;Adolescent;adolescent alcohol exposure;adolescent alcohol misuse;Adult;Affect;Alcohol abuse;Alcohol consumption;alcohol exposure;alcohol misuse;alcohol risk;alcohol use disorder;allodynia;Amygdaloid structure;Animals;Anxiety;Area;Attenuated;Behavior;Behavior assessment;Biological;Brain;cell type;Chondroitin ABC Lyase;Chronic;chronic pain;cognitive function;critical period;Data;Data Analyses;Data Collection;Data Correlations;density;Development;developmental plasticity;Digestion;Electrophysiology (science);Equilibrium;Ethanol;experimental study;Fiber;Genetic;genetic manipulation;global health;Health;Heavy Drinking;improved;in vivo;insight;Interneurons;Life;Long-Term Effects;mature animal;Measures;Medial;Mediating;midbrain central gray substance;multimodality;N-Methylaspartate;Nervous System;neural circuit;Neurobiology;Neurons;new therapeutic target;Nociception;Nociceptive Stimulus;optogenetics;Pain;pain processing;pain sensitivity;Pain Threshold;Parvalbumins;Pathway interactions;Pattern;Photometry;Physiology;pre-clinical;Prefrontal Cortex;Process;Property;Regulation;Research;response;Risk Factors;Rodent;Role;Safety;Slice;Stimulus;Structure;Synapses;synaptic function;Synaptic plasticity;Testing;Training;underage drinking

PROJECT_TITLE: Parvalbumin Interneuron Regulation of a Prelimbic to Ventrolateral Periaqueductal Gray Pathway for Modulating Pain Following Adolescent Intermittent Ethanol Exposure


NIH_SPENDING_CATS: Biotechnology;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Genetics;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Spontaneous preterm birth is a highly significant but understudied perinatal outcome that comprises the majority of premature births and has been linked to prenatal exposure to environmental chemicals, including phthalates. This study will investigate the mechanistic link between prenatal phthalate exposure, placental dysfunction, and spontaneous preterm birth using multi-omics data generated in the placenta. Findings from this study will inform chemical toxicological risk assessment and policy, as well as aid in the development of potential biomarkers of spontaneous preterm birth.

PI_NAMEs: PAQUETTE, ALISON GENEVIEVE (contact)

PROJECT_TERMS: absorption;Address;Assessment tool;Big Data;Biological Markers;Black race;Chemicals;Circulation;Clinical;cohort;Computational Biology;Data;Data Set;Development;Endocrine Disruptors;Environment;environmental chemical;Environmental Exposure;Epidemiology;epidemiology study;Etiology;Exposure to;Fatty Acids;Functional disorder;Future;Gene Expression;General Population;Genes;Goals;Health;High Prevalence;high risk;in utero;Inflammation;innovation;insight;knowledge translation;Length;Link;Mediating;Mediation;Medical;Medical Research;Messenger RNA;Metabolic Pathway;Metabolism;MicroRNAs;Minerals;modifiable risk;Molecular;Molecular Profiling;mRNA sequencing;Multiomic Data;multiple omics;National Institute of Environmental Health Sciences;neonatal morbidity;Neonatal Mortality;notch protein;novel;Outcome;Overlapping Genes;Participant;Pathway Analysis;Pathway interactions;perinatal outcomes;phthalates;Physiological;Placenta;Policies;Population;potential biomarker;Pregnancy;Pregnancy Trimesters;Pregnant Women;Premature Birth;prenatal;prenatal exposure;Public Policy;repaired;Research;Risk;Risk Assessment;Risk Factors;Role;Sampling;Second Pregnancy Trimester;Signal Transduction;Steroid biosynthesis;targeted treatment;Therapeutic Intervention;Third Pregnancy Trimester;Toxic effect;Toxicology;Transcriptional Regulation;transcriptomics;Underrepresented Populations;urinary

PROJECT_TITLE: Assessing how Prenatal Phthalate Exposure Disrupts Placental Transcriptional Regulation and Contributes to Changes in Gestational Length


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: St. Paul

ORG_NAME: MARPAM PHARMA, LLC

ORG_STATE: MN

PHR: PROJECT NARRATIVE To address the need for improved HIV therapies, particularly for patients who are ART non-compliant or ART naïve, the proposed studies will build on Marpam Pharma’s novel treatment strategy of using patients’ own T cells to target “hidden” HIV reservoirs containing actively replicating virus within lymphoid tissues. This project aims to develop a product for durable remission of HIV in patients who are not ART suppressed by generating a DNA construct optimized for this indication, developing a GMP-scalable method to produce CAR-T cells with the new construct, and to conduct an IND-enabling study that will assess the safety and efficacy of this product in an animal model of chronic HIV.

PI_NAMEs: ATHANASIOU, MARIA CONSTANCE (contact);SKINNER, PAMELA J

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: Address;Adherence;Affinity;Animal Model;Animals;antiretroviral therapy;Autologous;B-Lymphocytes;Binding;BLR1 gene;CAR T cell therapy;Caring;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;chemokine receptor;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;chronic infection;clinical development;Communicable Diseases;comparison control;Control Animal;CXCL13 gene;Cytotoxic T-Lymphocytes;Data;Devices;Disease;Disease remission;DNA;Fatigue;first-in-human;Genetic Engineering;HIV;HIV Infections;HIV resistance;HIV therapy;HIV-1;Homing;Human;Immune;improved;in vitro Assay;in vivo;Individual;Interruption;Investigation;Lymphoid;Lymphoid Cell;Lymphoid Tissue;Macaca;Macaca mulatta;Memory;Methods;migration;Modeling;Morbidity - disease rate;mortality;non-compliance;novel;Patients;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phase;phase 2 study;Phase I Clinical Trials;Phenotype;Physicians;Pilot Projects;pre-clinical;preclinical development;preclinical study;Public Health;Regimen;Reporting;Resistance;Safety;safety assessment;side effect;simian human immunodeficiency virus;Site;SIV;success;T cell response;T-Lymphocyte;treatment adherence;treatment strategy;United States;Viral;Viral Load result;Viral Physiology;Viral reservoir;viral RNA;viral transmission;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: A novel CAR-T cell therapy for the one-time treatment of chronic HIV infection in patients who are not ART suppressed

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-D(10)]