ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Relevance In all living organisms, a molecular machine called the ribosome synthesizes proteins, and decodes the genetic code of messenger RNA (mRNA) in the process of translation. Some mRNAs are translated orders of magnitude more efficiently than the others for reasons that are poorly understood. Translational control by mRNA structure plays an important role in cancer development, and is critical for the infectivity of human viruses such as immunodeficiency virus (HIV) and SARS-CoV-2, which causes the COVID-19 pandemic. We study how structural signals in mRNA regulate translation. Our studies will provide the basis for future development of antiviral and cancer therapies.

PI_NAMEs: ERMOLENKO, DMITRI  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: 2019-nCoV;3' Untranslated Regions;Address;antiviral drug development;Bacteria;Base Pairing;Biochemical;cancer therapy;Cells;Complex;COVID-19 pandemic;Development;DNA;Eukaryota;Future;Genetic Code;HIV;Human;human disease;immunodeficiency;Laboratories;Malignant Neoplasms;Messenger RNA;Microscopy;Molecular;Molecular Biology;Molecular Machines;Movement;Organism;Physiology;Play;Process;Protein Biosynthesis;Proteins;Ribosomes;Role;Signal Transduction;single molecule;Site;stem;Structure;Translating;Translation Initiation;Translation Process;Translational Regulation;translational study;Translations;Virus

PROJECT_TITLE: Structural Dynamics of Translation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: BRONX

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative: With development of preventative and therapeutic interventions, we were able to extend human life, but the final years or even decades of life are riddled with diseases and disability. Aging is a common risk factor for all aging-related diseases, therefore, if we could delay aging, we could extend the part of the life that is lived in good health. Our study aims to discover if broken functioning of the hypothalamus, the brain region that regulates hormones and metabolism of the entire body, is a reason for faster aging in some people, as these discoveries could lead to future therapies to delay aging.

PI_NAMEs: ALEKSIC, SANDRA  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Acarbose;Acceleration;Address;Adult;adult obesity;Age;age acceleration;Aging;aging process;aging related;aging related disease;Anisotropy;Area;Astrocytes;Award;Biochemical;Biological;Biological Aging;Biological Assay;Brain;Brain imaging;brain magnetic resonance imaging;Brain region;career;Chronic Disease;Clinical Data;clinical investigation;Cognition;cohort;Data;Data Analyses;Development;Diffusion Magnetic Resonance Imaging;disability;Disease;Doctor of Philosophy;Endocrinology;Estradiol;extend lifespan;Female;follow-up;frailty;Funding;Future;Genetic;Geriatrics;gerotherapeutic;Gliosis;Goals;Gonadal Hormones;Health;healthy aging;Hormonal;Hormones;Human;human old age (65+);Hypothalamic dysfunction;Hypothalamic structure;Image;Impaired cognition;indexing;insight;Knowledge;Lead;Leadership;Life;life span;Longevity;Longevity Pathway;Longitudinal cohort study;Magnetic Resonance Imaging;Measures;men;Mentors;Mentorship;Metabolic;Metabolic Diseases;Metabolism;Microglia;Modeling;mortality;multidisciplinary;Neurocognitive;neuroimaging;Neurosecretory Systems;Nordihydroguaiaretic Acid;novel;offspring;older adult;older men;older women;Outcome;Parents;Participant;Partner in relationship;personalized approach;Persons;Phenotype;Plasma;Positioning Attribute;preservation;Prevention;preventive intervention;Prospective cohort;Proteins;Proteome;Regulation;Research;resilience in aging;response;Risk Factors;Rodent;Role;Scientist;skills;Structure;Testing;Therapeutic Intervention;Training;translational scientist;Visit

PROJECT_TITLE: The Role of Hypothalamic Dysfunction in Accelerating Aging in Humans


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Hypertension (HTN) is especially morbid for rural individuals, who experience limited health care access, geographic isolation, low health literacy, and health-related disparities. The proposed research is relevant to public health by improving HTN treatment and management in disadvantaged rural individuals with this common, chronic condition.

PI_NAMEs: MAGNANI, JARED W. (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Adherence;Advisory Committees;Affect;Anti-Hypertensive Agents;arm;Articulation;barrier to care;Blood Pressure;blood pressure control;blood pressure medication;Blood Pressure Monitors;Cardiovascular Diseases;Cardiovascular system;Caring;Cellular Phone;Chronic;Clinical;Clinical assessments;clinical encounter;Clinical Trials Cooperative Group;Communication;comparison control;cost;Data;Devices;Diastolic blood pressure;digital;digital divide;digital health;digital technology;Disadvantaged;Disparity;Disparity population;Education;Educational Curriculum;effectiveness testing;Electronic Health Record;experience;Geography;Health;health application;health care availability;health care service utilization;Health education;health literacy;health related quality of life;Health Resources;Health Services Accessibility;Health system;Healthcare Systems;Home;Home Blood Pressure Monitoring;Hypertension;hypertension control;hypertension treatment;hypertensive;improved;Income;indexing;Individual;Information Systems;Infrastructure;Instruction;Intervention;intervention effect;intervention participants;literacy;Literature;low health literacy;Measurement;Measures;medication compliance;Methods;mHealth;Monitor;Morbidity - disease rate;mortality;Outcome;pandemic disease;Participant;patient engagement;patient oriented;Patient Outcomes Assessments;Patient-Centered Care;Patients;Pharmaceutical Preparations;Pharmacotherapy;Pharmacy facility;Preparation;Prevalence;primary outcome;Problem Solving;programs;Provider;Public Health;Quality of life;Randomized;randomized, clinical trials;recruit;remote assessment;Reporting;Research;Resources;Route;Rural;rural America;Rural Health;rural patients;Rural Population;rural setting;rurality;SARS coronavirus;secondary outcome;Self Care;Self Efficacy;social;social determinants;social disparities;social health determinants;Social isolation;Social Network;standard care;success;Surgeon;Text;treatment and outcome;virtual;Visit

PROJECT_TITLE: Multilevel mobile health program to improve rural hypertension

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: HOUSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PI_NAMEs: NGUYEN, HIEN VAN (contact)

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: Address;Algorithms;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;cancer diagnosis;Cardiovascular system;Cessation of life;Classification;Clinical;Cognitive;Collaborations;computer framework;Computer software;Computer-Assisted Diagnosis;Creativeness;design;Detection;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Errors;Diagnostic radiologic examination;distraction;Error Sources;Evaluation;Expert Systems;Fatigue;gaze;Goals;Hospitals;Human;imaging modality;improved;innovation;Institution;Instruction;Intention;iterative design;Joints;Knowledge;Learning;Lung nodule;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Medical;Methodology;Methods;Mission;Modeling;Monitor;multidisciplinary;multimodality;neglect;next generation;novel;Outcome;Pathologic;Performance;Principal Investigator;Process;Psychological reinforcement;Public Health;Pulmonary Embolism;radiologist;Radiology Specialty;Research Design;Retrospective Studies;Reverse engineering;Scanning;success;System;Systems Integration;theories;Thinking;Thoracic Radiography;Time;usability;User-Computer Interface;user-friendly;Visual;visual information;Work;Workload

PROJECT_TITLE: SCH: AI-DOCTOR COLLABORATIVE MEDICAL DIAGNOSIS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dissemination and Implementation Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care;Rehabilitation

ORG_CITY: DURHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF NEW HAMPSHIRE

ORG_STATE: NH

PHR: Project Narrative Individuals with Alzheimer’s disease (IAD) are at high-risk of premature relocation to long-term care settings primarily due to caregiver burden and concerns with functional capacity and safety. We propose to develop and test a smart home-linked assistive robot, Mobile Assistive Robot with Smart Sensing (MARSS), to support care of IAD in their own home, as well as optimize the behavior mechanism leading to its adoption. This research will contribute to the knowledge on innovative (yet real world) technological solutions to promote independence, health, and safety of IAD to sustain living at home, as well as the behavioral mechanisms involved in adoption of such technologies.

PI_NAMEs: ARTHANAT, SAJAY  (contact);BEGUM, MOMOTAZ

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Activities of Daily Living;Address;Admission activity;Adoption;Age;aging in place;Alzheimer's Disease;Anxiety;Assisted Living Facilities;assistive robot;Automation;Awareness;Behavior;behavior change;Behavioral;Behavioral Mechanisms;care burden;care costs;care recipients;Caregiver Burden;Caregiver well-being;Caregivers;caregiving;Caring;Clinical Trials;Cognition;Cognitive;cohort;Communities;community engagement;comparison control;Control Groups;cost;Data;Educational workshop;Effectiveness;efficacy testing;Emotional;experience;Family;Family Caregiver;Family health status;Family member;Focus Groups;Fostering;functional independence;group intervention;Health;Health Professional;high risk;Home;human-robot interaction;implementation fidelity;implementation framework;Individual;informal caregiver;innovation;Institution;Intervention;intervention effect;Interview;Knowledge;Link;Long-Term Care;Measures;Mediating;Memory;Mental Depression;Modality;Modeling;Monitor;new technology;Nursing Homes;Outcome;Outcome Measure;Peer Review;Personal Satisfaction;physical conditioning;Pilot Projects;pilot test;Population;premature;preservation;primary care setting;primary outcome;Process;programs;Protocols documentation;Publications;Quality of life;Randomized;Randomized, Controlled Trials;recruit;Research;Retirement;Robot;Robotics;Safety;scale up;Severity of illness;smart home;social assistive robot;Stress;Techniques;Technology;technology intervention;telehealth;Testing;theories;therapy development;Time;Training;Training Activity;Training Programs;United States National Institutes of Health;Validation;virtual experiments

PROJECT_TITLE: Effectiveness and adoption of a Smart home-based social assistive robot for care of individuals with Alzheimer's Disease

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Primary Health Care;Substance Misuse;Substance Misuse Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE There is an urgent need for effective substance use disorder prevention strategies for high-risk youth; currently, few evidence-based services exist, particularly within the context of the patient-centered medical home. We propose to pilot test and optimize a parent-youth dyadic intervention that aims to increase family resilience, strengthen coping skills, help families plan for the future, and improve youth outcomes. Our findings will directly inform the preparation of a randomized efficacy trial of thoroughly field-tested intervention model, with a long-term goal of preventing or reducing illicit and nonmedical prescription drug use among youth whose parents are in recovery from substance use disorder.

PI_NAMEs: KISTIN, CAROLINE J (contact)

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: acceptability and feasibility;Adolescence;Adolescent;Adolescent and Young Adult;adolescent substance use;Adult;Age;Age Years;Alcohols;arm;Behavioral;Child;Clinical Trials;Clinical Trials Design;Cognitive;Communication;Consent;Control Groups;coping;Coping Skills;Data;Development;disorder prevention;Drops;Drug usage;efficacy study;efficacy testing;efficacy trial;evidence base;experience;Family;Family member;Family Planning;Feasibility Studies;Feedback;field study;follow-up;Future;Goals;high risk;high risk population;Household;human centered design;Human Resources;improved;improved outcome;Infrastructure;Intervention;intervention delivery;intervention refinement;Intervention Trial;Interview;Knowledge;Life;Life Cycle Stages;Logistics;Marijuana;Measures;meetings;Mental Depression;misuse of prescription only drugs;Modeling;novel;older adult;Opioid;opioid epidemic;opioid use;opioid use disorder;Outcome;parent-child communication;Parent-Child Relations;parental involvement;Parents;patient centered medical home;Patient Recruitments;Peptide Initiation Factors;Pilot Projects;pilot test;Population;Population Heterogeneity;Preparation;prevent;Prevention strategy;preventive intervention;Primary Care;primary care setting;Problem Solving;Process;promote resilience;protective factors;prototype;provider intervention;Public Health;public health priorities;Randomized;randomized trial;Randomized, Controlled Trials;Recovery;Reporting;Research;resilience;Risk;Risk Factors;Series;Service delivery model;Services;skills;Structure;substance use;Substance Use Disorder;substance use prevention;substance use treatment;synthetic cannabinoid;Techniques;Testing;Time;United States Preventative Services Task Force;willingness;Work;young adult;Youth

PROJECT_TITLE: Substance use prevention for youth with parents in recovery: a pilot randomized controlled trial

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Prognostic biomarkers support precision-based treatments yet are lacking for patients with chronic lower back pain. Here, I aim to use advanced electroencephalogram-based neuroimaging strategies to identify and characterize biomarkers of dysfunctional brain networks (resting-state, cognitive, and emotional) in patients with chronic low back pain across time. The information gained from this study will increase our understanding of the neural processes underlying chronic pain and inform future patient-oriented research and solutions.

PI_NAMEs: LANNON, EDWARD W. (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Adult;Affect;Age;Anxiety;Area;Attention;Award;Behavioral;bioelectricity;Biological Markers;biopsychosocial;Brain;brain based;brain dysfunction;Brain imaging;career development;Central Nervous System;Cerebrum;Chronic low back pain;chronic pain;chronic pain patient;Classification;Clinical;clinical predictors;Cognitive;cognitive system;cognitive task;Collection;comorbidity;computer science;cost;Data;data acquisition;data analysis pipeline;deep learning;deep learning algorithm;deep learning model;Development;disability;Disease;Dorsal;Electroencephalography;Emotional;Emotional Disturbance;emotional symptom;Environment;experience;Fatigue;follow-up;Functional Magnetic Resonance Imaging;Funding;Future;global health;Goals;Grant;High Prevalence;Image;Impaired cognition;improved;innovation;K-Series Research Career Programs;Machine Learning;Magnetic Resonance Imaging;Maintenance;Measurable;Measurement;Mental Depression;Mentors;Meta-Analysis;Methodology;Modality;Modeling;Modems;Modernization;multimodal data;neural;neural network;Neurobehavioral Manifestations;neuroimaging;Neuropsychology;Pain;pain chronification;Pain intensity;Pain interference;pain symptom;patient oriented research;Patient Recruitments;Patients;Persons;Physical Function;Physiology;predictive marker;Principal Investigator;Process;prognostic;Prognostic Marker;Psychology;Psychophysiology;Research;Research Personnel;Research Project Grants;Resolution;response;Rest;sex;signal processing;Signal Transduction;Site;skills;somatosensory;Source;statistical learning;Symptoms;System;Time;Training;Training Programs;Translating;treatment stratification;Writing

PROJECT_TITLE: Characterization of Longitudinal EEG Biomarkers in Chronic Low Back Pain

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Given the urgent need to develop novel pharmacological treatment for alcohol use disorder (AUD), and the promising preliminary reports of the fast-acting and long-lasting effects of psychedelic compounds, we propose to investigate the therapeutic potential of psychedelic N,N-dimethyltryptamine (DMT) plus a brief course of psychotherapy (including Motivational Enhancement Therapy (MET)) on alcohol use disorder (AUD) in a proof- of-concept, randomized (1:1), placebo-controlled, double-blind, parallel group, laboratory study and clinical trial.

PI_NAMEs: BASSIR NIA, ANAHITA  (contact);D'SOUZA, DEEPAK CYRIL

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: Abstinence;Acute;Adverse event;alcohol abuse therapy;Alcohol consumption;alcohol measurement;alcohol use disorder;Alcohols;analog;Animals;Anxiety;anxiety reduction;anxiety symptoms;Attention;Back;Banisteriopsis;behavioral sensitization;Binding;Brief Psychotherapy;Cause of Death;Clinical;Clinical Trials;comparison control;conditioned place preference;Consumption;consumption measures;depressive symptoms;Development;Diagnosis;Diphenhydramine;Dose;Double-Blind Method;drinking;DSM-V;efficacy evaluation;Ethanol;experience;FDA approved;follow-up;Hallucinogens;Heavy Drinking;Hospitals;Hour;HTR2A gene;Human;improved;Indigenous;Individual;interest;Interview;Intravenous;intravenous administration;Laboratories;Laboratory Study;Literature;Long-Term Effects;Lysergic Acid Diethylamide;Measures;Medical;Medicine;men;Mental Depression;Mental disorders;Meta-Analysis;Methodology;Methods;Monitor;motivational enhancement therapy;Mus;N,N-Dimethyltryptamine;novel;Observational Study;Odds Ratio;Oral Administration;Outcome;Outpatients;Participant;Patient Self-Report;Pharmaceutical Preparations;Pharmacological Treatment;Phase;Placebo Control;Placebos;preclinical study;primary outcome;Psilocybin;psychoeducation;Psychotherapy;Questionnaires;Randomized;Randomized Controlled Clinical Trials;Reporting;Risk;Safety;Sample Size;Self Administration;South American;Substance Use Disorder;Tea;Therapeutic;Therapeutic Effect;timeline;Tribes;United States;Visual;Woman

PROJECT_TITLE: The potential therapeutic effects of N, N-dimethyltryptamine (DMT) on alcohol use disorder (AUD)

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Fungal infections resistant to current antimicrobials is a growing public health concern that has received much media attention. The proposed project seeks to address this problem by characterizing and further developing a novel therapeutic – peptides derived from a bacterial protein with efficacy against human fungal agents in multiple animal models. Specifically, the goals are to understand and improve the efficacious features of the peptide and elucidate its mechanism of action.

PI_NAMEs: GARSIN, DANIELLE A;LORENZ, MICHAEL C (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Address;alpha helix;Animal Model;anti-fungal agents;anti-microbial peptide;Antibiotics;antimicrobial;Antimicrobial Resistance;Attention;Bacterial Proteins;bacteriocin;Binding;Biochemical;Biochemistry;Biological;Blood Circulation;Caenorhabditis elegans;Candida albicans;Candida auris;Candidiasis;Cardiovascular Diseases;Catheters;cell envelope;Cells;Characteristics;Chemicals;Clinical;Communicable Diseases;Cryptococcus neoformans;Data;Development;Disease;Drug resistance;emerging pathogen;Enterococcus faecalis;extracellular vesicles;Genetic;Goals;Health;Human;Hydrophobicity;improved;Infection;innovation;insight;Investigation;Knowledge;Libraries;Malignant Neoplasms;Mammals;Medical Device;microbial;Microbial Biofilms;microorganism interaction;Modeling;Morbidity - disease rate;mortality;Mucous Membrane;Multi-Drug Resistance;Mus;mutant;Mycoses;Nature;novel strategies;novel therapeutic intervention;novel therapeutics;opportunistic pathogen;Oral candidiasis;oropharyngeal thrush;Outcome;Pathogenesis;pathogenic fungus;Pathogenicity;peptide drug;Peptides;Persons;Predisposition;prevent;Public Health;Publishing;rational design;Rattus;Research;Resistance;screening;Source;Structure;Taxonomy;Testing;Therapeutic;Vaginitis;Venous;vesicle transport;Virulence;Work;wound

PROJECT_TITLE: Mechanism of Fungal Virulence Inhibition by a Bacterial Peptide

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

PHR: Project Narrative The 2024 Signal Transduction by Engineered Extracellular Matrices Gordon Research Conference (STEEM GRC) will focus on the interface of biology and engineering and gather multidisciplinary scientists to disseminate state-of-the-art research in highly active areas including single cell biology, multi-scale modeling, mechanobiology, and engineered extracellular matrices (ECM) to investigate and control cell function. The resulting multidisciplinary education will benefit our diverse colleagues as they advance our understanding of how ECMs interface with cellular signaling networks, both in regenerative medicine and in understanding and treating human disease.

PI_NAMEs: PEYTON, SHELLY R. (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: 3D Print;Adoption;Area;Basic Science;Biochemistry;Biocompatible Materials;biofabrication;Biological Process;Biology;Biopolymers;Biotechnology;career;Cell Death;Cell Physiology;Cell Therapy;Cells;Cellular biology;Collaborations;commercialization;Communities;Complex;Creativeness;Data;Development;Discipline;Disease;disease model;Dysplasia;Education;Engineering;Environment;experience;Extracellular Matrix;Extracellular Matrix Proteins;Faculty;faculty mentor;Fibrosis;Fostering;Germination;Goals;graduate student;Health;Heterogeneity;Human;human disease;improved;Incubated;Leadership;Malignant Neoplasms;mechanical force;Mechanics;meetings;Modeling;Molecular;multi-scale modeling;multidisciplinary;Mutation;neoplastic cell;next generation;novel;Organoids;Pharmacologic Substance;Philosophy;Physiology;Play;Postdoctoral Fellow;pre-doctoral;receptor;regeneration potential;regenerative cell;Regenerative Medicine;Reporting;Reproducibility;Research;Research Personnel;Role;Science;Scientist;Senior Scientist;sex;Signal Transduction;Solid;Standardization;Structure;symposium;System;Systems Biology;Talents;Technology;Therapeutic;Thinking;Time;Tissues;Translations;Underrepresented Populations;Vocational Guidance;Woman;Work

PROJECT_TITLE: 2024 Signal Transduction by Engineered Extracellular Matrices Gordon Research Conference and Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-F (J1)]


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Anti-retroviral therapy (ART) has saved many patients with HIV infection, which now is a treatable disease. Increased cardiovascular risk in long-term HIV survivors on ART with no detectable virus load, however, is projected to be a global health burden. Despite its clinical impact, underlying mechanisms remain unclear. Inflammation plays an important role in the development of atherosclerosis. The HIV-associated protein Nef appears to promote inflammation. We will use a multi-disciplinary research platform to discover novel mechanisms for accelerated atherosclerotic vascular disease in HIV survivors and to provide molecular bases for new therapies.

PI_NAMEs: AIKAWA, ELENA ;AIKAWA, MASANORI  (contact);SINGH, SASHA A

PROGRAM_OFFICER_NAME: PLAYFORD, MARTIN P

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Aging;antiretroviral therapy;Apoptotic;Area;Arterial Fatty Streak;ATAC-seq;atherogenesis;atheroprotective;Atherosclerosis;atherosclerosis risk;Attenuated;base;Biological;Biological Assay;Biology;Blood Vessels;cardiovascular risk factor;Cells;Chronic;Clinical;clinical translation;Data;data integration;Data Science;Development;Disease;Epigenetic Process;Equilibrium;Event;experimental study;extracellular vesicles;Family;Feedback;Future;General Population;global health;Goals;Heterogeneity;high risk;HIV;HIV Infections;HIV Long-Term Survivors;Human;Immune;Impairment;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Interdisciplinary Study;Knock-in Mouse;latent HIV reservoir;Lesion;lipid nanoparticle;Macrophage;Macrophage Activation;Mediator;Modernization;Molecular;Multiomic Data;multiple omics;Mus;Necrosis;novel;novel therapeutics;Pathway Analysis;Pathway interactions;Patients;Persons;Phagocytosis;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Play;precision medicine;Proteins;Proteomics;receptor;Resolution;RNA Interference;Role;single cell analysis;single-cell RNA sequencing;Survivors;System;Testing;therapeutic target;Thinness;transcriptomics;Vascular Diseases;vascular inflammation;Viral load measurement;Viral Load result;Virion

PROJECT_TITLE: Nef in impaired efferocytosis: a novel mechanism for vascular disease in HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-D (02)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Health Services;Hearing Loss;Pediatric;Prevention;Rehabilitation

ORG_CITY: MC LEAN

ORG_NAME: AMERICAN COCHLEAR IMPLANT ALLIANCE FDN

ORG_STATE: VA

PHR: Project Narrative With the expansion of cochlear implant candidacy, the pool of people who are likely to qualify now includes children and adults with more residual hearing including those with single sided deafness or asymmetric hearing loss. Expected CI outcomes are characterized by a fuller hearing experience that includes spatial hearing, listening in noise, access to environmental sounds, and enjoyment of music as well as associated benefits like cognition in older adults and quality of life in recipients of all ages. The CI conferences will explore these topics, addressing how CI professionals can best provide appropriate clinical services and reach underserved groups while still maintaining a sustainable clinical practice.

PI_NAMEs: SORKIN, DONNA L (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Address;Adult;Age;Age Months;American;Anatomy;asymmetric hearing loss;Auditory Prosthesis;aural rehabilitation;base;Basic Science;bilingualism;Boston;Canada;career;Caring;Characteristics;Child;Childhood;Climacteric;Clinic;Clinical;clinical practice;Clinical Research;Clinical Services;Cochlear implant procedure;Cochlear Implants;Cognition;Cognitive;Continuity of Patient Care;Country;deafness;Dementia;Device Designs;Devices;Education;Effectiveness;Emotional;Environment;European;Evaluation;experience;Family;Family Characteristics;Family member;Financial Support;Frequencies;Funding;gene therapy;Genetic;Grant;Growth;Habilitation;Health;health care delivery;Healthcare;Hearing;hearing impairment;hearing preservation;Implant;implantation;improved;innovation;interest;International;Interview;Learning;life span;literacy;Maps;Measures;medical appointment;Medicare;meetings;Methods;Modeling;Music;Noise;Nonprofit Organizations;older adult;Operative Surgical Procedures;Otolaryngologist;Outcome;Outcome Measure;Participant;Pathway interactions;patient population;Patient-Focused Outcomes;Patients;Persons;Population;posters;Procedures;Process;programs;Psychologist;Qualifying;Quality of life;rate of change;Recommendation;Rehabilitation therapy;Research;Research Personnel;research to practice;Residual state;Role;Scholarship;Scientist;Service delivery model;Services;Side;Social Workers;sound;special interest group;Special needs;Specificity;Speech Pathologist;speech recognition;Students;symposium;Techniques;Technology;telehealth;Testing;Time;treatment planning;Underserved Population;United States National Institutes of Health;vestibular system;Visit;Washington

PROJECT_TITLE: Cochlear Implant Clinical Research Symposia (Three Years) Covering the Years 2024 through 2026

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

ORG_STATE: MD

PHR: Project Narrative A core mission of the National Eye Institute (NEI) is to support research on the retina and early visual system in order to build scientific knowledge that facilitates the development of novel therapies for blindness. The FASEB Science Research Conference on “Retinal Neurobiology and Visual Processing,” held biennially for 30 years, is the premier meeting in the field and supports the mission of the NEI by assembling a diverse group of early-career and established scientists to openly exchange new theories, techniques and research findings on the retina in a secluded setting. The meeting supports early-stage trainees and junior faculty, with an emphasis on women and members of underrepresented groups in science, and includes interactive workshops on novel methodology and career development; opportunities to present research findings in formal oral and poster presentations; and informal opportunities to interact with peers and form new collaborations.

PI_NAMEs: DEMB, JONATHAN B (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: American;Atmosphere;Automobile Driving;Award;Behavior;Biology;Blindness;career;career development;cell type;Cellular Neurobiology;Code;Collaborations;Communities;Computational Biology;computational neuroscience;Creativeness;Data;design;Development;Developmental Biology;Disease;educational atmosphere;Educational workshop;Electrophysiology (science);Ensure;Environment;Equilibrium;experience;Faculty;Feedback;Fostering;genetic approach;Goals;graduate student;Health;Image;information processing;Information Theory;interest;Knowledge;Massachusetts;meetings;member;Methodology;Mission;Molecular;National Eye Institute;Natural regeneration;Neurobiology;Neurosciences;novel;novel therapeutics;Oral;Participant;Pathway interactions;peer;Photoreceptors;Play;Postdoctoral Fellow;posters;pre-doctoral;Prize;Process;Productivity;professor;programs;Public Speaking;Publishing;Recommendation;recruit;Relaxation;Reporting;Request for Proposals;Research;Research Personnel;Research Support;Retina;Retinal Ganglion Cells;Schedule;Science;Scientist;Senior Scientist;Soccer;social;Societies;sound;success;Surveys;symposium;Synapses;System;Technical Expertise;Techniques;theories;Thinking;Time;Travel;Underrepresented Populations;Vision;Vision research;visual processing;Visual System;Walking;Woman;Women's Group;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (04)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Data Science;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Rare Diseases;Stomach Cancer

ORG_CITY: DALLAS

ORG_DEPT: SURGERY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE The project proposes to identify novel biomarkers that predict response to immune checkpoint inhibitors (ICI) and new therapies to enhance ICI efficacy in patients with gastric cancer. The proposal is relevant to public health because the expected results will help improve patient quality of life by avoiding futile therapy given to patients who will not benefit from ICI and increase survival by improving the effects of the therapy. Thus, the proposal is relevant to the NIH’s mission to reduce illness and lengthen life.

PI_NAMEs: HWANG, TAE HYUN ;WANG, SAM C. (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Affect;Algorithms;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;Biological Markers;Biological Response Modifiers;biomarker identification;Cancer Biology;cancer care;Cancer Patient;cancer therapy;Cell Communication;Cells;checkpoint therapy;Classification;Clinical;clinically actionable;Collaborations;Complex;Computational Science;Data;data handling;Data Set;data streams;Decision Making;Decision Trees;digital pathology;Engraftment;explainable machine learning;Fibroblasts;Gene Expression;Genes;genetic signature;Genomics;Goals;Heterogeneity;Human;Image;Immune;Immune checkpoint inhibitor;Immune system;Immunocompetent;Immunocompromised Host;Immunotherapy;improved;improved outcome;inhibitor therapy;innovation;insight;Life;Ligands;machine learning algorithm;Malignant Neoplasms;malignant stomach neoplasm;Manuals;Mediating;Methodology;Microsatellite Repeats;Mission;Molecular;multidimensional data;multidisciplinary;multimodal data;multimodal learning;multimodality;Mus;novel;novel marker;novel therapeutics;Organoids;Output;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Preclinical Testing;predicting response;predictive marker;Probability;Process;Proteomics;Public Health;Publications;Publishing;Quality of life;receptor;Reporting;Research Personnel;responders and non-responders;response;Sampling;Scientist;Slide;Surgeon;survival outcome;targeted treatment;Techniques;Technology;Testing;tool;Toxic effect;transcriptome sequencing;transcriptomics;Treatment-related toxicity;tumor;tumor microenvironment;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Uncertainty;United States National Institutes of Health;unpublished works;whole slide imaging;Work

PROJECT_TITLE: Using artificial intelligence to discover spatial, genomic, and pathologic biomarkers to guide and augment immune checkpoint inhibitor therapy for gastric cancer

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: RESTON

ORG_NAME: TERATOLOGY SOCIETY

PHR: Project Narrative  For 63 years, the Society for Birth Defects Research and Prevention (BDRP) has promoted basic and clinical research to understand the causes and mechanisms of birth defects, the potential effects of drug, chemical, infectious, or other exposures on the developing embryo/fetus, improve reproductive health, understand developmental origins of adult disease, and translate these discoveries into clinical practice. The Annual Meeting provides a forum for scientists, clinicians, and science policy regulators from academic, industrial, and government sectors to present cutting-edge research, exchange ideas and information, and engage in discussions among established experts in the field, new researchers, and students. The goals of the BDRP align with the goals of NICHD in advancing the knowledge on reproduction and embryo-fetal and postnatal development, as evidenced by the theme of the 2024 Annual Meeting, Addressing Disparities in Birth Defects Research and Prevention.

PI_NAMEs: LUPO, PHILIP  (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Achievement;Address;adverse pregnancy outcome;Area;Award;Barker Hypothesis;Basic Science;Biochemical Pathway;Biological Process;career;Career Choice;career development;Chemicals;Clinical;clinical practice;Clinical Research;Collaborations;Communication;Complex;Congenital Abnormality;congenital anomaly;Dedications;design;Development;developmental disease;Discipline;Disparity;Dysmorphology;Education;Educational workshop;Embryo;embryo/fetus;Ensure;Epidemiologist;Epidemiology;epidemiology study;equity, diversity, and inclusion;Event;experience;exposure pathway;Face;Feedback;fetal;forging;Foundations;Functional disorder;Funding;Future;Goals;Government;graduate student;Health Professional;Home;improved;Industrialization;Information Specialists;innovation;Interdisciplinary Study;Journals;Knowledge;meetings;member;microbiome;Minority Groups;Mission;Morphology;multidisciplinary;National Institute of Child Health and Human Development;Nature;neuropathology;neurotoxicology;new technology;Oligonucleotides;Outcome;outreach;Peer Review;Pharmaceutical Preparations;Placenta;Policies;Poly-fluoroalkyl substances;posters;postnatal development;prevent;Prevention;Prevention Measures;programs;Public Health;Publications;Publishing;recruit;Reproduction;reproductive;Reproductive Health;reproductive system disorder;Research;Research Activity;Research Personnel;Risk;Role;Science Policy;Scientific Societies;Scientist;Societies;Spinal Dysraphism;stem cells;student mentoring;Students;symposium;Technology;Teratology;Training and Education;Translating;Translational Research;Travel;Underrepresented Populations;Underserved Population;Work

PROJECT_TITLE: Society for Birth Defects Research and Prevention Conferences 2024–2028

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Opioids;Precision Medicine;Stimulant Use and Misuse;Substance Misuse;Women's Health Research

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Relevance: Individual differences, social factors and sex are variables that influence vulnerability, maintenance and treatment outcomes in human drug addiction. The research proposed in this application will utilize socially housed female and male monkeys self-administering cocaine to further explore behavioral (alternative reinforcers, impulsive choice, punishment, cognition), pharmacological (chronic drug treatments) and brain changes using positron emission tomography. Results from these studies should aid in the development of personalized medicine strategies for cocaine use disorders.

PI_NAMEs: NADER, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Acute;addiction;Affect;American;Animal Model;Behavior Control;Behavior Therapy;Behavioral;Brain;Brain imaging;Chronic;Clinical Trials;Cocaine;Cocaine Abuse;cocaine self-administration;Cocaine use disorder;Cocaine Users;Cognition;cognitive performance;contingency management;Data;design;Development;Dextroamphetamine;discounting;Dopamine;Dose;Drug abuse;Drug Addiction;Drug Modelings;drug testing;Dynorphins;environmental enrichment for laboratory animals;FDA approved;Female;Food;Funding;Goals;Grant;Human;Imaging Techniques;Impulsivity;Individual Differences;Injections;Intervention;Intravenous;intravenous drug use;kappa opioid receptors;Laboratories;Macaca fascicularis;Maintenance;male;Measures;Mediating;Modeling;Monkeys;Neurobiology;non-drug;nonhuman primate;Opioid agonist;Outcome;personalized medicine;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Phase;Positron-Emission Tomography;pre-clinical;Primates;Punishment;Raclopride;receptor;Recovery;reinforcer;Research;Research Design;Research Project Grants;response;Schedule;Self Administration;Series;sex;Sex Differences;sex variable;side effect;social;Social Behavior;Social Environment;social factors;Social Hierarchy;social stress;System;Time;Translational Research;Treatment Efficacy;Treatment Failure;Treatment outcome;Work

PROJECT_TITLE: Mechanisms Mediating Cocaine Abuse in Socially Housed Female and Male Monkeys

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-P (02)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects

ORG_DEPT: PHARMACOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE We are using a multidisciplinary approach to understand molecular mechanisms of peripheral nerve injury in order to disrupt intracellular pathways that promote the maintenance of chronic pain. Findings from this work will provide important information on safer, efficacious and better tolerated medications for the treatment of neuropathic pain.

PI_NAMEs: ZACHARIOU, VENETIA  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Ablation;Absence of pain sensation;activating transcription factor;Acute;addiction;Affect;Affective;Behavior;Behavioral;behavioral study;Binding;Biochemical;Biochemistry;Bioinformatics;Biological Assay;Biosensor;C Fiber;candidate validation;cell type;Cells;central sensitization;chemotherapy induced neuropathy;chronic neuropathic pain;chronic pain;chronic pain management;chronic painful condition;Co-Immunoprecipitations;Complex;Cre driver;Critical Pathways;Cyclic AMP-Dependent Protein Kinases;Cytoplasm;Data;Dependence;Down-Regulation;effective therapy;efficacious intervention;Emotional;Event;expectation;Female;Fiber;Fractionation;G-Protein-Coupled Receptors;Gene Expression;Gene Modified;Gene Targeting;Gene Transfer;Genes;Genetic;Genetic Transcription;GPCR Signaling Pathway;GTP-Binding Protein Regulators;GTP-Binding Proteins;Heterotrimeric GTP-Binding Proteins;Hypersensitivity;In Vitro;Inflammation;injured;Injury;insight;interdisciplinary approach;Intervention;Ion Channel;Knock-out;Knockout Mice;Maintenance;Mediating;Mediator;Methodology;Modeling;Molecular;mouse genetics;mouse model;Mus;mutant;Names;nerve injury;neurochemistry;Neurons;NF-kappa B;Nociception;nociceptive response;novel;Nuclear;Opioid;overexpression;Pain;pain chronification;Pain management;painful neuropathy;Pathway interactions;Pattern;Peripheral;Peripheral nerve injury;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;Physics;Play;Population;Postoperative Pain;prevent;protein complex;Proteins;Publishing;receptor;Recovery;response;RGS Proteins;RNA;Role;Sensory;Signal Transduction;Signaling Protein;single nucleus RNA-sequencing;Site;spared nerve;Spinal Ganglia;Structure;Surgical incisions;Synapses;Testing;Thalamic structure;Tissues;tool;transcription factor;transcriptomics;transmission process;vector;Viral;Western Blotting;Work

PROJECT_TITLE: Studies on RGS4-Regulated Pathways in Models of Neuropathic Pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Physical Injury - Accidents and Adverse Effects;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative  Device-associated infections severely limit the success of many orthopaedic procedures, and current antibiotic treatments have limited effectiveness and may lead to antibiotic-resistant bacteria. We will engineer new classes of materials for local delivery of potent antimicrobial agents to eliminate bacterial infection and support bone repair.

PI_NAMEs: GARCIA, ANDRES J (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Acute;Affect;anti-microbial drug;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteria;Bacterial Antibiotic Resistance;Bacterial Counts;Bacterial Infections;bactericide;Benchmarking;Biocompatible Materials;Biological;BMP2 gene;bone;Bone Cements;bone fracture repair;bone healing;bone repair;Cells;chronic infection;cost;cytokine;Debridement;Defect;Development;Devices;Dose;Effectiveness;Engineering;Enzymes;Femoral Fractures;Fracture;Funding;Gel;Goals;Health Care Costs;Histology;Histopathology;Hospital Costs;Hydrogels;Immune;Implant;Infection;Infection prevention;Inflammation;Inflammatory;Injectable;innovation;insight;Integrins;learning materials;Lysostaphin;Measures;Mechanics;Microbial Biofilms;Modeling;mouse model;Mus;novel;novel strategies;Operative Surgical Procedures;Orthopedic Procedures;Osteomyelitis;Osteotomy;Outcome;pathogen;Patient-Focused Outcomes;Procedures;Radial;recruit;Regimen;repaired;Research;response;Rifampin;Safety;sample fixation;Serum;Sheep;sheep model;Site;Staphylococcal Infections;Staphylococcus aureus;Staphylococcus epidermidis;success;synergism;Testing;Therapeutic;Tissues;Toxic effect;transcriptome sequencing;translatable strategy;translational model;United States National Institutes of Health

PROJECT_TITLE: Bactericidal hydrogels for bone repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (83)]


ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative  This proposal seeks funding to support increased participation from a diverse group of early career scientists, researchers and clinicians during three in-person Congresses of the International Society of Electrophysiological Kinesiology (ISEK) and four virtual conferences over a five-year period. Funding will be used to support travel and family caregiving costs, augmenting the programming ISEK has developed to enhance scientific, networking, and professional development opportunities for all our early career researchers. These efforts will assist ISEK in promoting an inclusive environment that supports the development of the next generation of neuromuscular health researchers and the diversity of ideas that they bring to the fields of electrophysiology and kinesiology.

PI_NAMEs: PERREAULT, ERIC JON (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Africa;Area;Asia;Award;base;Basic Science;broadening participation research;career;caregiving;clinical care;Communities;Congresses;cost;Country;Coupled;COVID-19 pandemic;design;Development;Discipline;doctoral student;Educational process of instructing;Educational workshop;Electromyography;Electrophysiology (science);Engineering;Ensure;Environment;Equity;Europe;Event;Faculty;family caregiving;family support;Feedback;Fostering;Funding;Future;geographic disparity;Geographic Locations;Goals;graduate student;Grant;Health;Health Occupations;improved;Industry;innovation;innovative technologies;International;Kinesiology;Knowledge;Lead;Leadership;Learning;Left;Measurement;meetings;member;Mission;Monitor;Motor;motor impairment;multidisciplinary;Nature;neuromuscular;next generation;Oceania;Pathologic;Pathway interactions;Persons;Physical Education;Physical therapy;Postdoctoral Fellow;Professional Organizations;professor;programs;Recommendation;Recording of previous events;recruit;Rehabilitation therapy;Research;Research Personnel;Science;Scientist;Sensory;Shapes;skills;social;Societies;success;Surveys;symposium;System;Technology;Time;Travel;Underrepresented Populations;virtual;webinar;Woman;Work

PROJECT_TITLE: Support for the International Society of Electrophysiology and Kinesiology Congress

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Dietary Supplements;Nutrition

PHR: PROJECT NARRATIVE The 2024 FASEB Science Research Conference on Trace Elements in Biology and Medicine will bring together researchers performing the latest, cutting-edge research that advances our understanding of the roles of trace elements in biology, nutrition, health, and disease. Trace elements such as iron, zinc, copper, manganese, and selenium are essential for life, and imbalances in their uptake, distribution, storage, or excretion result in a large number of nutritional and metabolic disorders. This conference plays a critical role in bridging basic and applied research in trace elements and in training the next generation of scientists in this exciting and expanding field.

PI_NAMEs: BARTNIKAS, THOMAS BENEDICT (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Academia;Algae;Applied Research;Area;Bacteria;Basic Science;bioinformatics tool;Biological Models;Biology;Biomedical Research;career;career development;Carrier Proteins;Clinical;Collaborations;collaborative environment;Copper;Coupled;COVID-19 pandemic;design;Development;Disabled Persons;Discipline;Disease;Education;Educational workshop;Event;Excretory function;Family member;Florida;Fostering;Goals;graduate student;Health;Homeostasis;Human;Imaging Techniques;Individual;Industry;interest;Iron;Knowledge;Life;Manganese;Medicine;meetings;Mentors;Metabolic Diseases;Metabolism;Metals;Micronutrients;model organism;Molecular;Molecular Biology;Molecular Chaperones;Molecular Genetics;Mus;new technology;next generation;novel;Nutrient;nutrition;Nutrition Disorders;Nutritional;Nutritional Requirements;Oral;Organism;Outcome;Participant;physically handicapped;Physicians;Physiological Processes;Play;Postdoctoral Fellow;posters;Problem Solving;programs;Research;research and development;Research Personnel;Resolution;Role;Schedule;Science;Scientific Advances and Accomplishments;Scientist;Selenium;Series;Signal Transduction;skills;Study models;supportive environment;symposium;System;Technical Expertise;Trace Elements;trafficking;Training;Underrepresented Minority;Underrepresented Populations;uptake;Woman;Yeasts;Zinc

PROJECT_TITLE: Trace Elements in Biology and Medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (J3)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Economic choice is observed when individuals choose between multiple options based on subjective preference – for example out of a restaurant menu. It is specifically impaired in several clinical conditions including schizophrenia and drug addiction. Our current goal is to dissect the neural circuit underlying economic decisions using a combination of two-photon calcium imaging and optogenetic stimulation in mice. 1

PI_NAMEs: PADOA-SCHIOPPA, CAMILLO  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Address;Affect;Anatomy;Animals;Behavior;Behavioral;Brain region;Calcium;calcium indicator;Cells;Choice Behavior;Clinical;Clinical Data;Computer Models;control trial;Decision Making;design;Drug Addiction;Economic Models;Economics;Electric Stimulation;experimental study;Frontotemporal Dementia;Functional Imaging;Funding Mechanisms;Genetic;Goals;high reward;high risk;holographic stimulation;Image;Impairment;Implant;Individual;individual variation;innovation;insight;Interneurons;Juice;Left;lens;Lesion;Link;Literature;Logistics;Major Depressive Disorder;Measures;Mental disorders;Microscope;Monkeys;mouse model;Mus;Nervous System Disorder;neural circuit;neuroeconomics;Neurons;neurophysiology;Neurosciences;Optics;optogenetics;Outcome;Output;Performance;Population;Positioning Attribute;preference;Preparation;Procedures;Process;Property;Protocols documentation;Pyramidal Cells;redshift;Research;Resolution;Rest;Restaurants;Schizophrenia;Side;Technical Expertise;Time;tool;two-photon;Work

PROJECT_TITLE: Causal manipulation of a decision circuit in the mouse orbitofrontal cortex

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-A (02)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Brain Disorders;Data Science;Drug Abuse (NIDA only);Genetics;Human Genome;Substance Misuse

ORG_CITY: CLEMSON

ORG_DEPT: GENETICS

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Health Relevance Statement The goal of this research is to develop new statistical methods for the comprehensive analysis of Substance Use Disorder (SUD). By integrating diverse data types from human and model organism samples, these methods aim to identify affected cells, driver regulators, and gene regulatory networks associated with SUD, thereby advancing our understanding of addiction at a systems level and contributing to future efforts in addiction prevention and treatment. The relevance of this research lies in addressing SUD as a critical global health issue with significant risks to physical and mental well-being, as well as economic burdens.

PI_NAMEs: DUREN, ZHANA  (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Acute;addiction;Addictive Behavior;Address;Affect;Alcohol dependence;Automobile Driving;Binding Proteins;bioinformatics tool;Biology;Brain;caudate nucleus;cell type;Cells;Chromatin;Cocaine;comparison control;Complex;complex data;Comprehension;Computing Methodologies;Consumption;Control Groups;Data;deep neural network;Development;differential expression;disorder risk;diverse data;DNA;Drosophila genus;Drug Exposure;Economic Burden;Environment;epigenomics;Exhibits;fly;frontal lobe;Future;gene environment interaction;Gene Expression;gene expression variation;gene regulatory network;Genes;Genetic;genetic variant;Genetic Variation;genome wide association study;Genomics;Genotype;global health;Goals;Health;Heritability;Heroin;Heroin Dependence;high reward;high risk;Human;human genomics;Individual;insight;knock-down;Link;Maintenance;Mathematics;Mental Health;Methodology;Methods;Modality;model organism;Modeling;Molecular;Multiomic Data;multiple data types;network models;novel;novel therapeutics;Organism;Outcome;Pharmaceutical Preparations;Phenotype;physical conditioning;Population;Predisposition;preference;Prevention;problem drinker;Published Comment;Regulatory Element;Research;Research Personnel;Research Project Grants;Reverse Transcription;Risk;RNA Interference;Role;Sampling;single cell ATAC-seq;single-cell RNA sequencing;Statistical Methods;Structure;Substance Use Disorder;System;Systems Biology;Tissue Sample;tool;trait;transcription factor;transcriptome sequencing;Uncertainty;Variant;Well in self

PROJECT_TITLE: Statistical methods for gene regulatory analysis of substance use disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKP-N (J1)]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE To avoid potential harm, we are equipped with brain circuits that allow detecting, learning, and responding to perceived threats in our environment. Dysregulation in these processes often denotes psychopathological conditions such as post-traumatic stress and anxiety disorders. This study examines how specific neuronal populations process perceived threats to guide behavioral defenses, thus providing novel insights into the neural mechanisms underlying threat processing in both health and disease.

PI_NAMEs: BHATTI MAZO, DIONNET LEANDRO (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Anatomy;Anxiety Disorders;Architecture;Arousal;avoidance behavior;Avoidance Learning;Behavior;Behavioral;Behavioral Paradigm;biological adaptation to stress;Brain;Brain region;Calcium;cell type;Cells;Code;Corticotropin-Releasing Hormone;CRH gene;Cues;Data;Disease;Doctor of Philosophy;Environment;Excitotoxic lesion;experimental study;Family;Functional disorder;G-Protein-Coupled Receptors;genetic approach;Genetic Transcription;Goals;Health;Heterogeneity;Hippocampus;Human;Hypothalamic structure;Image;in vivo;insight;interest;Laboratories;Lateral;Learning;Link;Maps;Mathematics;Mediating;Mental disorders;Molecular;molecular dynamics;Monitor;Mood Disorders;Motivation;Mus;neural;neurobiological mechanism;neuromechanism;Neurons;neuropsychiatric disorder;novel;Optics;optogenetics;Outcome;Output;Physiological;Population;Population Process;Positioning Attribute;Post-Traumatic Stress Disorders;Process;Punishment;rapid detection;receptor;recruit;response;Role;Sensory;sensory stimulus;Signal Transduction;single nucleus RNA-sequencing;Stimulus;Stress;Stressful Event;Structure;System;Testing;theories;Therapeutic;Training;transcriptomics;virus genetics;Work

PROJECT_TITLE: Functional and molecular organization of lateral septum in threat processing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: Newark

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Sculpted Light in the Brain Conference (SLB 2024) will foster collaborations between neuroscientists, computer scientists, optics researchers, and other scientists who use and develop cutting-edge technologies to observe and control neural activity in the intact brain. This meeting will gather established scientists and the next generation of researchers from these fields to discuss progress on enabling real time optical interrogation of the brain.

PI_NAMEs: OLDENBURG, IAN ANTON (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Adoption;Area;Award;Biological;Boston;Brain;Brain Diseases;BRAIN initiative;Calcium;California;career;Child Care;cis-male;Cognition;Collaborations;Communication;Communities;computer science;computer scientist;Computing Methodologies;cost;Critical Thinking;Data;Dedications;design;Development;Devices;Electronics;Ensure;Environment;Esthesia;experimental study;Exposure to;Feedback;fighting;Fostering;Foundations;Functional Imaging;Future;Generations;Goals;Grant;Image;innovation;interdisciplinary collaboration;interest;International;Light;London;meetings;member;men;Methods;Mission;Modeling;Monitor;Nature;Nervous System;Nervous System Disorder;neural;neural implant;neuroregulation;Neurosciences;Neurosciences Research;next generation;novel;novel therapeutics;Optical Methods;Optics;optogenetics;Paraplegia;Paris, France;Patients;Perception;posters;Process;programs;Prosthesis;Quadriplegia;Research;Research Personnel;Research Project Grants;Robotics;Scientist;Senior Scientist;Series;Shapes;Specificity;Speed;success;Suggestion;Surveys;symposium;Techniques;Technology;Theoretical model;Time;tool;Travel;Underrepresented Minority;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: Sculpted Light in the Brain Conference 2024

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-K (43)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

PHR: PROJECT NARRATIVE:  Neuromodulatory systems, such as acetylcholine and norepinephrine, play a profound role in regulating the activity and function of cortical circuits. However, little is known about the spatiotemporal dynamics of neuromodulatory release during behavior and cognition. This proposal will use novel imaging techniques to determine the state-dependent pattern of noradrenergic signaling in the intact cortex, the impact of norepinephrine on cortical activity, and the coordination between different neuromodulatory systems. We expect our findings to provide important insights into neuromodulatory signaling in the healthy brain and to identify potential therapeutic targets to ameliorate pathology in disease.

PI_NAMEs: CARDIN, JESSICA A (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Acetylcholine;Address;Alzheimer's Disease;Anatomy;Animals;Area;Arousal;Attention;awake;basal forebrain cholinergic neurons;Basal Nucleus of Meynert;Behavior;Behavior monitoring;Behavioral;Brain;Calcium;Cerebral cortex;cholinergic;Cognition;Cognitive;cognitive function;Color;Complex;Coupled;Coupling;Data;density;Disease;Electrophysiology (science);Exhibits;experimental study;Goals;Image;imaging approach;in vivo;innovation;insight;Link;locus ceruleus structure;Mediating;Monitor;Motor;Mus;Neocortex;neocortical;neural;Neurodegenerative Disorders;Neuromodulator;neuronal patterning;Neurons;neuroregulation;noradrenergic;Norepinephrine;novel;novel imaging technique;Parkinson Disease;Pathology;Pattern;Perception;pharmacologic;Play;prevent;Process;Regulation;Reporter;Resolution;Role;Sensory;Signal Transduction;Sleep;spatiotemporal;System;Techniques;Testing;therapeutic target;Variant;Work

PROJECT_TITLE: Neuromodulatory regulation of cortical functional connectivity


NIH_SPENDING_CATS: Aging

PHR: Project Narrative The 3’,5’-cyclic adenosine monophosphate (cAMP) and 3’,5’-cyclic guanosine monophosphate (cGMP) pathways, which are regulated by cyclic nucleotide phosphodiesterases (PDEs), modulate a number of critical physiological processes. As such, targets within these signaling cascades have long been of high interest to drug discovery efforts. This meeting will bring together scientists from a wide range of disciplines to discuss cyclic nucleotide signaling across numerous organs to promote cross-field fertilization of ideas, collaboration and the identification of novel mechanisms by which these signaling cascades can be harnessed for therapeutic gain.

PI_NAMEs: KELLY, MICHY PATRICE (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Academia;Address;age-related disease;Aging;aging related disease;Alzheimer's Disease;Amaze;Area;Atmosphere;Automobile Driving;Awareness;Biological Markers;Biological Models;Biology;Biomedical Engineering;Biosensor;Biotechnology;Calcium;Cardiac;Cardiology;Cardiovascular system;career;Clinic;Clinical Trials;Collaborations;college;Colon;commune;Communities;Cyclic AMP;Cyclic GMP;Cyclic Nucleotides;Dedications;design;Discipline;Disease;diversity and inclusion;drug discovery;Ensure;Environment;experience;Experimental Models;extracellular;Feeling;Fellowship;Female;Fertilization;Fostering;Friends;Fruit;Funding;Germany;graduate student;Growth;GTP-Binding Proteins;Heart failure;Hour;Human;Immunologist;Immunology;improved;Individual;Industrialization;Inflammation;interest;International;life span;Light;Literature;Location;Lung;Maine;Malignant Neoplasms;Mediating;Medicine;meetings;Mentors;Neurosciences;next generation;novel;Oncologist;Organ;Parasites;Parkinson Disease;Pathway interactions;PDE2 phosphodiesterase;Phosphodiesterase Inhibitors;phosphoric diester hydrolase;Phosphorylation;Physiological Processes;Physiology;Play;Postdoctoral Fellow;posters;Primates;programs;Psychiatry;Pulmonology;receptor;recruit;Research;Research Personnel;Rodent;Role;Science;Scientist;Seasons;Series;side effect;Signal Pathway;Signal Transduction;social;Socialization;Stream;Structure;symposium;System;Therapeutic;therapeutic target;therapeutically effective;Time;tool;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Vascular Dementia;Woman;Work;Yeasts

PROJECT_TITLE: 2024 Cyclic Nucleotide Phosphodiesterases Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Gene Therapy;Genetics;Immunotherapy;Neurodegenerative;Neurosciences

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: PROJECT NARRATIVE Development of novel anti-tau protein therapies is a critical need in the pursuit of interventions for Alzheimer’s disease (AD) and related dementias. Here, we will develop and test (in a mouse model of tauopathy) a novel immuno-gene therapy approach involving AAV-mediated expression of a single chain variable domain from an anti-tau antibody, called TNT2, that binds an N-terminal motif displayed in a conformation-dependent fashion and is closely linked to tau toxicity. This work will allow the initial development and validation of a novel anti-tau therapy that could have a significant impact towards treating AD and related dementias.

PI_NAMEs: KANAAN, NICHOLAS M (contact)

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: adenovirus mediated delivery;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Antibodies;Antibody Therapy;antigen binding;aromatic L-amino acid decarboxylase deficiency;Axon;Axonal Transport;Behavior;Binding;Biological Assay;Canavan Disease;Capsid;Cells;Clinical Trials;cognitive performance;combat;Coupled;Data;Degenerative Disorder;Dependovirus;Development;Disease;disorder prevention;gene therapy;Human;human disease;Huntington Disease;immuno-gene therapy;Immunotherapy;Impairment;in vitro Assay;Intervention;Light;Link;Lysosomal Storage Diseases;Macular degeneration;Measures;Mediating;Modeling;Modification;Molecular Conformation;Monoclonal Antibodies;monomer;mouse model;multicatalytic endopeptidase complex;Mus;N-terminal;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;Neurons;neurophysiology;neurotoxicity;novel;Organ;Parkinson Disease;Passive Immunization;Pathogenicity;Pathologic;Peptide Signal Sequences;Peripheral;Phase;Phenotype;Phosphoric Monoester Hydrolases;Physiological;Property;protein degradation;protein protein interaction;Proteins;Reagent;Recombinant adeno-associated virus (rAAV);Route;Series;Signal Pathway;Signal Transduction;Synapses;synaptic function;System;Tail;tau aggregation;tau conformation;tau mutation;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic;Therapeutic Agents;Toxic effect;Ubiquitin;Validation;Veins;Viral Vector;Wild Type Mouse;Work

PROJECT_TITLE: Development and Validation of a Novel Anti-Pathogenic Tau Conformation (TNT2) scFv Immuno-Gene Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-H (55)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: The meeting will bring together diverse researchers investigating the process of extracting diagnostic information from medical images to render accurate and efficient diagnostic decisions. Opportunities for advanced, interdisciplinary training of young scientists interested in medical image perception research and its relevance to disease prevention and treatment are often quite limited. Since 1997, 128 trainees have been awarded MIPS scholarships, having a significant impact on the field by creating opportunities and offering supportive mentoring at this formative stage in the trainee’s career to enhance their research potential and likelihood of success as independent basic science and clinician-scientist researchers.

PI_NAMEs: KRUPINSKI, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: 3-Dimensional;Academia;Acquired Immunodeficiency Syndrome;American;Area;Artificial Intelligence;automobile accident;Award;Basic Science;Behavior;Calibration;career;Clinical;clinical decision-making;clinical practice;Clinical Trials;Cognition;Cognitive Science;Color;Communities;Computer Models;computer scientist;Computers;cost;Decision Aid;Decision Making;Dedications;deep learning;design;Detection;Development;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Errors;Diagnostic Imaging;diagnostic technologies;Dimensions;Discrimination;disorder prevention;Doctor of Philosophy;Engineering;ergonomics;Evaluation;Failure;Fatigue;Floods;forging;Frequencies;Future;Goals;Grant;health care quality;Healthcare;Healthcare Systems;Human;Image;Image Analysis;image processing;imaging system;Imaging technology;improved;Individual;Industry;Institute of Medicine (U.S.);interest;International;Intervention;Investments;Judgment;Knowledge;large datasets;Learning;Malignant Breast Neoplasm;Malpractice;Medical;Medical Errors;Medical Imaging;Medicine;meetings;Mentors;method development;Methods;Minority;Modeling;Modern Medicine;Modernization;Nonprofit Organizations;Ophthalmology;Outcome;Output;Pathologist;Patient Care;Patients;Pattern;Perception;Performance;Physician's Role;Physicians;Population;Postdoctoral Fellow;Prevention;Process;Prognosis;prognostic;Psychologist;Psychophysics;radiological imaging;radiologist;Reader;Reporting;Research;Research Personnel;Role;Running;Scholarship;Scientist;screening;Series;Societies;Source;Statistical Models;statistics;Students;success;symposium;Technology;Telemedicine;tool;Training;trend;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;vision science;Visualization;whole slide imaging;Woman;Work

PROJECT_TITLE: Medical Image Perception Society (MIPS) XX

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-F (J1)]


NIH_SPENDING_CATS: Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: The goal of the current application is to characterize functionally distinct non-coding regulatory elements in major neuronal types for which rare and common variant risk loci are most enriched in neuropsychiatric disorders, identify their target genes, and elucidate how noncoding variants affect the transcription of key genes for neuronal cell identity and activity-regulated signaling networks. The proposed research has the potential to develop an innovative approach and unravel the neurobiological functions of the vast but in the brain largely unexplored non-coding sequences of the human genome, which is relevant to the mission of NIH to acquire new knowledge to help prevent, detect, diagnose, and treat disease and disability.

PI_NAMEs: YANG, NAN  (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Affect;autism spectrum disorder;Autopsy;Binding;Biological;Biology;Brain;Cells;cohort;Complex;Coupled;Data;Derivation procedure;Development;Diagnosis;disability;Disease;disorder risk;Enhancers;Epigenetic Process;Etiology;family burden;Foundations;Future;Gene Expression;Genes;Genetic;Genetic Transcription;genetic variant;genome wide association study;genome-wide analysis;Goals;Human;human disease;Human Genetics;Human Genome;innovation;insight;interdisciplinary approach;Knowledge;Maps;Methodology;Mission;Molecular;Neurobiology;Neurons;neuropsychiatric disorder;next generation sequencing;novel;novel therapeutic intervention;Pluripotent Stem Cells;prevent;promoter;Regulatory Element;Research;Research Personnel;Resources;Rest;Risk;risk variant;Role;Schizophrenia;Signal Transduction;Societies;socioeconomics;Technology;Tissues;transcription factor;Translating;United States National Institutes of Health;Untranslated RNA;Variant;Work

PROJECT_TITLE: Functional mapping of noncoding regulatory variants in human neuronal subtypes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(57)-S]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Prevention;Substance Misuse;Telehealth

ORG_CITY: ROCHESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative This project aims to address the need for robust, rigorous and computationally efficient methods for optimizing Just-In-Time Adaptive Interventions (JITAIs) to prevent and treat substance use disorders (SUD). Although the proposed methods are motivated by micro randomized trials (MRTs) in SUD, they can be extended to observa- tional studies and employed to develop effective JITAIs in other health domains as well. The methods developed in this project will help SUD scientists to more effectively leverage emerging technologies (e.g., mobile and wear- able devices) to deliver support in a timely and ecological manner.

PI_NAMEs: ERTEFAIE, ASHKAN  (contact);NAHUM-SHANI, INBAL BILLIE

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: adaptive intervention;Address;Adoption;analytical method;Chronic Disease;Clinical;Collaborations;Computer software;Data;Data Analytics;Data Collection;Data Set;Development;digital health;disorder prevention;Distal;Documentation;Dose;Ecological momentary assessment;Effectiveness;Effectiveness of Interventions;Emerging Technologies;Emotions;experience;Experimental Designs;follow up assessment;follow-up;Funding;Future;Generations;handheld mobile device;Health;Individual;infancy;Intention;Intervention;intervention delivery;intervention effect;Location;machine learning method;Methodology;Methods;mhealth interventions;mobile computing;Modernization;Monitor;Motivation;Nature;novel;Observational Study;open source;Outcome;Patient Self-Report;Pattern;Persons;prevent;randomized trial;reduced substance use;Relapse;Relaxation;Reproducibility;Research Methodology;Research Personnel;response;Risk;Scientist;sensor;Social Environment;Specific qualifier value;standard care;Statistical Methods;substance use;Substance Use Disorder;systematic review;Techniques;Technology;therapy design;therapy development;Time;uptake;wearable device;Wireless Technology;Work

PROJECT_TITLE: Novel Methods to Inform mHealth Interventions for Substance Use

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 LXF-E (J1)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

PHR: Narrative Collagens are a major component of the pancreatic cancer microenvironment, which has been implicated in the regulation of tumor malignancy. Our research focuses on understanding the function of a unique collagen receptor, known as DDR1 (Discoidin Domain Receptor 1), that transmits collagen signals in pancreatic cancer cells, mediating metastatic progression. Our studies deploy a synergistic team of experts focused on dissecting the roles of collagen-stimulated DDR1 in pancreatic cancer signaling and metastasis, with the future goal of targeting this signaling axis for improving pancreatic cancer patient survival.

PI_NAMEs: COPPE, JEAN-PHILIPPE FRANCOIS MARIE;CRAWFORD, HOWARD C. (contact);FRIDMAN, RAFAEL A.

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Ablation;Adenocarcinoma;arm;Basement membrane;Behavior;behavior in vitro;Cancer Etiology;cell growth;Cell Line;Cells;Cessation of life;Collagen;Collagen Receptors;Data;DDR2 gene;Detection;discoidin domain receptor 1;discoidin receptor;Disease Progression;EGFR gene;Engineering;Epithelium;Exhibits;Extracellular Matrix;Family;Fibrillar Collagen;Fibroblasts;Future;Genetic;Goals;Human;Immune;Implant;improved;In Vitro;in vivo;in vivo Model;infiltrating duct carcinoma;innovation;Invaded;Ligands;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Mediating;member;Mesenchymal;Metastatic Adenocarcinoma;migration;Modeling;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;novel;Outcome;overexpression;Pancreas;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathologic;Pathway interactions;Phosphotransferases;Process;promoter;receptor;Receptor Protein-Tyrosine Kinases;recombinase;Regulation;Research;response;Role;scaffold;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Surface;Survival Rate;Techniques;Testing;Thick;Tissues;transmission process;tumor;tumor growth;tumor microenvironment;tumor progression;tumor xenograft;United States;Xenograft procedure

PROJECT_TITLE: Collagen Signaling in Pancreatic Cancer

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Minority populations, which constitute a growing fraction of the total US population, experience a significantly higher risk of death or disability from heart disease or stroke, and have historically been medically underserved, in part due to a lack of minority cardiovascular researchers. The goal of this R25 program is to increase the numbers of underrepresented minorities pursuing careers in cardiovascular medical research by providing undergraduate underrepresented minority (URM) students with a short-term mentored research experience in the laboratories of Stanford Medicine’s Cardiovascular Institute. Participation in mentored research increases the degree to which URM students identify as scientists, which in turn increases the likelihood that URM students persist in research careers.

PI_NAMEs: DE JESUS PEREZ, VINICIO A;RED-HORSE, MARY ;WU, JOSEPH C. (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Address;Affect;African American population;Area;Asian Pacific Islander;Awareness;Behavioral;Cardiopulmonary;Cardiovascular Diseases;Cardiovascular system;career;Career Choice;career development;Cause of Death;Cessation of life;Clinic;Clinical;cohort;college;Diagnosis;disability;Disease;Doctor of Philosophy;Education;Education Projects;education research;Educational Curriculum;Equus caballus;Evaluation;experience;Faculty;faculty mentor;Feedback;Funding;Genetic;Goals;Heart Diseases;high risk;Hispanic;Hispanic Americans;improved;Individual;innovation;interest;Knowledge;Laboratories;Latino;Link;Lung Diseases;Medical;Medical Education;Medical Research;medical schools;medically underserved;Medicine;member;Mentors;Mentorship;Minority;Minority Groups;minority investigator;minority undergraduate;Minority-Serving Institution;Monitor;mortality risk;Native Americans;Outcome;Population;Positioning Attribute;Problem Solving;Professional Competence;Program Evaluation;programs;Qualifying;recruit;Reproducibility;Research;Research Activity;Research Personnel;Research Technics;Resources;responsible research conduct;role model;Science;Scientist;skills;Statistical Data Interpretation;STEM career;Stroke;Structure;student mentoring;Students;success;summer research;Talents;Teacher Professional Development;Training;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Students;United States;Universities;Variant;Work

PROJECT_TITLE: Stanford Undergraduate URM Summer Cardiovascular Research Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-A (J1)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project narrative The International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI) is the premier meeting in the medical image computing and computer assisted intervention communities. In this proposal, we request funds to support the participation of US-based students and early career investigators with focus on underrepresented and minority groups in the MICCAI editions of 2024, 2025 and 2026. This support will provide them with an opportunity for visibility in an established international audience, access to the MICCAI Mentorship Program, and exposure to a large number of educational, community-driven events and networking opportunities.

PI_NAMEs: LINGURARU, MARIUS GEORGE ;PORRAS PEREZ, ANTONIO REYES  (contact)

PROJECT_TERMS: Academy;African;American;Asian;Award;Biomedical Computing;biomedical imaging;Cardiology;career;career development;Career Mobility;Collaborations;Communities;community intervention;Computer Assisted;Computer Vision Systems;Computer-Assisted Diagnosis;Computer-Assisted Surgery;Country;Development;digital imaging;Disabled Persons;disabled students;disadvantaged background;Discipline;Disparity population;diversity and inclusion;Double-Blind Method;Education;Educational workshop;empowerment;Equity;equity, diversity, and inclusion;Ethnic Origin;European;Event;Exposure to;Female;Fostering;Funding;Future;Goals;Growth;Healthcare;image guided intervention;image processing;imaging system;Income;Industrialization;Industry;innovation;Institution;International;Intervention;Joints;Journals;Knowledge;Learning;Medical;Medical Imaging;Medicine;meetings;Mentors;Mentorship;Minority;Minority Groups;minority investigator;Morocco;Oncology;Operative Surgical Procedures;Oral;outreach;Paper;Pathology;Peer Review;Physicians;Physiology;Policies;Postdoctoral Fellow;posters;preservation;programs;Psychiatry;Publications;Race;Radiology Specialty;Recording of previous events;Request for Proposals;Research;Research Personnel;Rewards;Robotics;Rotation;Scientist;Series;Shapes;social;social organization;Societies;student participation;Students;supportive environment;symposium;System;Time;Translating;Travel;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;virtual reality;Visualization;Weight;Woman;Work


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

PHR: PROJECT NARRATIVE  Motivated states have profound influences on behavioral selection. While decades of work have focused on the neural mechanisms underlying motivation for specific drives like hunger and thirst, we know far less about how the brain generates motivation for specific social drives. This study will determine whether and how the brain may encode divergent socially motivated states at the neural, behavioral, and molecular level.

PI_NAMEs: MACK, NANCY ROSE (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Aggressive behavior;Animals;Area;Automobile Driving;Behavioral;Brain;Brain region;Calcium;Cells;Custom;density;Electrophysiology (science);experimental study;Female;fighting;flexibility;Future;Gene Expression;Gene Expression Profile;Hunger;Hypothalamic structure;in vivo;Individual;insight;Libido;Light;male;Methods;Modeling;Molecular;Molecular Profiling;motivated behavior;Motivation;Mus;neural;neuromechanism;neuronal cell body;Neurons;Nose;novel;Opsin;Optics;Partner in relationship;Personal Satisfaction;Phase;Play;Population;redshift;Reporter;Research;Rewards;Role;single nucleus RNA-sequencing;social;Social Behavior;social bias;social disparities;Social outcome;Specificity;System;Techniques;Testing;Thirst;Time;tool;transcription factor;transcriptomics;Work

PROJECT_TITLE: Decoding the specificity of social drives

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (02)]


NIH_SPENDING_CATS: Bioengineering;Cancer

PHR: PROJECT NARRATIVE The Systems Approaches to Cancer Biology (SACB) meeting aims to bring together scientific leaders and early-stage investigators in Cancer Systems Biology to build and foster a thriving and collaborative field through sharing scientific advances. The meeting will be held in the Fall every other year and be run as a hybrid meeting, with both in-person and virtual attendees. The meeting addresses many aspects of cancer biology and covers a diversity of computational/mathematical modeling approaches.

PI_NAMEs: COSTELLO, JAMES CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Academia;Address;anti-cancer research;Area;Biological Process;Biomedical Research;Cancer Biology;career;Career Mobility;Collaborations;Committee Members;Communities;Complex;Computer Models;computer science;Data Science;Data Set;design;Development;Discipline;Disease;dynamic system;Engineering;Environment;epigenomics;Equilibrium;Ethical Issues;ethnic identity;Event;experience;falls;Family;Fostering;Funding;Future;Gender Identity;Genes;genome-wide;Genomics;Geography;Goals;graduate student;Growth;Happiness;Heterogeneity;Hour;Hybrids;Individual;Industry;interest;Malignant Neoplasms;Marketing;Mathematical Biology;mathematical model;Mathematics;Measurement;meetings;Mentorship;Mind;Molecular;Molecular Biology;National Cancer Institute;novel;novel strategies;Occupations;Oral;Outcome;Patients;peer;Persons;Physics;posters;Prize;professor;programs;Proteins;racial identity;Recording of previous events;recruit;Research;Research Personnel;Running;Scholars Program;Science;Scientific Advances and Accomplishments;Scientist;symposium;System;Systems Biology;Technology;Training;translational oncology;Travel;undergraduate student;Underrepresented Populations;virtual;Work

PROJECT_TITLE: Systems Approaches to Cancer Biology Meeting

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (J1)]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Immunotherapy;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE: Graft-versus-host disease (GVHD) and the sequelae of immunosuppression have been a major barrier to the success of allogeneic hematopoietic stem cell transplantation (allo-HSCT), which can potentially cure hematological cancers such as leukemia, lymphoma and myeloma. Id3, a transcriptional regulator, regulates the formation and maintenance of tissue-infiltrating T cells that are critical for GVHD maintenance and leukemia control through coordinating the expression of genes engaged in effector differentiation and memory T cell development. The investigations proposed will define the effect of tissue-infiltrating alloreactive T cells in mediating pathogenicity of GVHD and leukemia control, characterize the role of Id3 in these cells during GVHD, and establish the beneficial effect of ID3-engineered chimeric antigen-receptor (CAR) T cells on eliminating leukemia.

PI_NAMEs: XUE, HAI-HUI ;ZHANG, YI  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Ablation;Address;Adoptive Transfer;Alloantigen;Allogenic;antileukemic activity;Biological;Biology;Blood;cancer immunotherapy;Cancer Relapse;CAR T cell therapy;Cause of Death;CD8-Positive T-Lymphocytes;Cells;chimeric antigen receptor T cells;CRISPR/Cas technology;Data;effector T cell;Engineering;exhaustion;Exhibits;Exposure to;Functional disorder;Gastrointestinal tract structure;Gene Expression;gene-editing approach;Genes;genetic approach;Genetic Transcription;graft versus host disease induction;graft vs host disease;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Human;Immune;Immunity;Immunosuppression;Immunosuppressive Agents;inducible gene expression;Infection;Infiltration;innovation;insight;Investigation;isoimmunity;Lead;leukemia;Liver;Lymphoid Tissue;Lymphoma;Maintenance;Mediating;Memory;Molecular;Multiple Myeloma;Mus;novel;NR4A2 gene;nuclear factors of activated T-cells;Pathogenicity;PD-1 blockade;Pharmaceutical Preparations;Phenotype;preservation;Process;progenitor;programmed cell death protein 1;programs;Property;Proteins;Reaction;Recurrence;Regulation;Reporter;Repression;residence;Resistance;response;restraint;RIPK1 gene;RIPK3 gene;RNA Splicing;Role;self-renewal;Skin;stem;stemness;success;System;T cell infiltration;T cell response;T memory cell;T-Cell Activation;T-Cell Development;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Tissue Expansion;tissue resident memory T cell;Tissues;transcription factor;translational approach;Transplant Recipients;tumor;Tumor Antigens

PROJECT_TITLE: ID3 regulation of tissue-infiltrating T cells mediating graft-versus-host disease and leukemia rejection

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Physical Activity;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: Narrative Rates of depression are very high in persons who have had a stroke and treatments are generally not effective. We will study the efficacy of combining aerobic exercise and non-invasive brain stimulation (repetitive transcranial magnetic stimulation) in treating people with post-stroke depression. Our goal is to use the information collected to help design optimal treatments for many of the common consequences of stroke, something that would be incredibly valuable to people who have had a stroke and their families.

PI_NAMEs: FENG, WUWEI ;GREGORY, CHRIS  (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: active method;Address;Aerobic Exercise;Affect;anti-depressive agents;Brain;Centers of Research Excellence;Communities;Data;depressive symptoms;design;Disease remission;Double-Blind Method;effective therapy;efficacy evaluation;efficacy study;Ensure;Environment;Equilibrium;Exclusion;experimental study;falls;Family;FDA approved;follow-up;functional gain;Funding;Goals;gray matter;Hamilton Rating Scale for Depression;health related quality of life;improved;indexing;Individual;Joints;Magnetic Resonance Imaging;Measures;Mental Depression;Methods;Monitor;motor recovery;Neuroanatomy;Neurologic;Neuronal Plasticity;neurophysiology;neuropsychiatry;neuroregulation;noninvasive brain stimulation;novel strategies;optimal treatments;Outcome;Patients;Persons;Pharmaceutical Preparations;Pharmacological Treatment;phase II trial;post stroke;post stroke depression;potential biomarker;Prevalence;primary outcome;Quality of life;Randomized;Recovery;Recovery of Function;Rehabilitation therapy;repetitive transcranial magnetic stimulation;Research;Resources;response;Risk;Role;Seizures;Selective Serotonin Reuptake Inhibitor;Severities;side effect;Site;Stimulus;Stroke;stroke recovery;stroke survivor;success;symptomatic improvement;Symptoms;Techniques;Testing;therapy development;Thick;Time;Transcranial magnetic stimulation;treadmill;Treatment Efficacy;treatment group;treatment response;United States National Institutes of Health;vascular depression;Walking;Withholding Treatment

PROJECT_TITLE: Combining rTMS & aerobic exercise to treat depression and improve post-stroke walking (RESTORATION)

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: The Fungal Genetics Conference brings together fungal biologists working on most major fungal systems and promotes communication and collaboration between those working on fungi related to human health including Medical mycologists, working on fungi that cause diseases of people and those working on food security as well as others working on plant pathogens, saprobes and symbiotic fungi. This interaction allows students interested in mycology to find and pursue opportunities for research careers in Infectious Diseases and other areas towards reducing the impact of fungi on human health. Fungi also serve as important model systems to understand basic processes in cells that when altered result in diseases of people based on the presence in fungi of many genes and metabolic and regulatory pathways relevant to those altered in people impacted by these diseases.

PI_NAMEs: ORBACH, MARC J (contact)

PROGRAM_OFFICER_NAME: STRICKLER-DINGLASAN, PATRICIA M

PROJECT_TERMS: anti-fungal agents;Area;Aspergillus fumigatus;Biocontrols;Biological Models;Biology;Biotechnology;Candida;career;Career Mobility;Cells;Coccidioides;Collaborations;Communicable Diseases;Communication;cost;Cryptococcus;Development;Disease;disorder prevention;Ecology;Evolution;food security;Fostering;functional genomics;Funding;Fungal Drug Resistance;fungal genetics;fungus;Gene Expression Regulation;Genes;Genetic;genetic approach;Genome engineering;Genomic approach;Genomics;Goals;Government;Health;Human;Industry;innovation;interest;International;Medical;meetings;member;Metabolic Pathway;Metabolism;Microbial Biofilms;Modeling;Molds;Molecular;Morphology;Mucor;new technology;novel;novel strategies;pathogen;Pathogenesis;Pathogenicity;Pathology;Persons;Plants;Postdoctoral Fellow;posters;Privatization;Process;programs;Regulatory Pathway;Research;Research Personnel;Scientist;Students;symposium;System;The science of Mycology;theories;Therapeutic;Thinking;tool;Travel;Underrepresented Populations

PROJECT_TITLE: 32nd Fungal Genetics Conference

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LK-D (J1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Pediatric;Prevention;Primary Health Care;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Pediatric obesity is an epidemic that is disproportionately experienced by children from lower socioeconomic backgrounds, underscoring the need to identify novel, modifiable risk factors for obesity prevention, particularly for those at greatest risk. Mounting evidence suggests that enhancing children's sleep may represent a novel target for prevention approaches that may be particularly well suited for delivery by allied health professionals in primary care settings, thus having potential for high public health impact.

PI_NAMEs: HART, CHANTELLE NOBILE (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Accelerometer;acceptability and feasibility;actigraphy;Address;Adoption;Adult;African American;Asthma;Behavior;Behavior Therapy;Behavioral;behavioral health;behavioral sleep intervention;Black race;Caring;Characteristics;Child;Childhood;Chronic;Clinical;Clinical Trials;Communities;Data;dietary;Disease;Disease Management;Disparity;Eating;Eating Behavior;Education;Educational Background;Effectiveness;Enrollment;Epidemic;Equity;Ethnic Origin;excessive weight gain;experience;experimental study;Family;flexibility;follow-up;Goals;Health;Health Promotion;Healthcare;Healthcare promotion;healthy weight;Height;Hour;improved;innovation;Intervention;intervention delivery;Life Style;Maintenance;Measures;middle childhood;Mission;Modeling;modifiable risk;National Institute of Diabetes and Digestive and Kidney Diseases;novel;novel strategies;Obesity;obesity in children;obesity prevention;obesity treatment;Outcome;pediatrician;Personal Satisfaction;Physical activity;Prevention approach;preventive intervention;Primary Care;primary care setting;Primary Health Care;profession allied to medicine;Public Health;Race;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Registered nurse;Regulation;Resources;response;Risk;Risk Factors;satisfaction;School-Age Population;Signal Transduction;Sleep;Sleep Deprivation;socioeconomic disparity;Socioeconomic Status;socioeconomics;synergism;Telephone;translational potential;Translations;treatment as usual;Weight;Weight Gain;weight gain prevention;Well Child Visits

PROJECT_TITLE: Feasibility and Preliminary Efficacy of a Brief Behavioral Sleep Intervention for Excessive Weight Gain Prevention in Primary Care

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]