ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Patient Safety

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE  Focused ultrasound ablation is an FDA-approved procedure for the treatment of essential tremor that allows performing brain surgery without the need for incisions or anesthesia. We identified three main areas to optimize this emerging treatment: identification of the target, standardization of the ultrasound delivery, and monitoring of the ultrasound treatment. We propose to use 3-D tractography, a high-resolution modeling technique of the nerve tracts within the brain to identify the target and standardize ultrasound delivery to 70% of its volume while monitoring the execution of the treatment with conventional and non-conventional magnetic resonance imaging.

PI_NAMEs: KRISHNA, VIBHOR  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: 3-Dimensional;Ablation;Age;American;Anatomy;Anesthesia procedures;Animal Experiments;Animals;Area;Atlases;Autopsy;Blinded;Brain;brain surgery;brain tissue;Cell Nucleus;Climacteric;Clinical;Control Groups;Controlled Clinical Trials;Data;Dependence;Diffusion Magnetic Resonance Imaging;disability;Dose;drinking;Eating;Edema;Essential Tremor;experimental group;FDA approved;Focused Ultrasound Therapy;Glass;Goals;Histopathology;human study;Hygiene;Image;Image-Guided Surgery;improved;Intervention;Intraoperative Monitoring;Lesion;Life;Location;Magnetic Resonance;Magnetic Resonance Imaging;Measures;Medicare;Modeling;Monitor;necrotic tissue;Nerve;Nervous System Disorder;neuroimaging;Neurologic Deficit;neurosurgery;Operative Surgical Procedures;Oral;Outcome;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phase;porcine model;post intervention;Procedures;Protocols documentation;psychologic;Random Allocation;Randomized;Recurrence;repository;research clinical testing;Resistance;Resolution;response;Risk;safety and feasibility;safety testing;Sensitivity and Specificity;sex;side effect;Specific qualifier value;Standardization;Structure;success;Surgical incisions;Symptoms;Techniques;Temperature;Testing;Thermography;Tissue Differentiation;Tissues;tractography;Tremor;Ultrasonic Therapy;ultrasound;Videotape;Visual;Visualization

PROJECT_TITLE: 3-D Tractography Focused Ultrasound Ablation for Essential Tremor

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Understanding how stem cell numbers are determined in tissues has fundamental relevance in order to uncover novel tools to promote tissue regeneration that can be utilized to ameliorate diseased conditions. Our work provides evidence that myofibers play a central role in determining skeletal muscle stem cell numbers in tissues in a cell nonautonomous manner. This proposal aims at defining the role of myofibers in determining muscle stem cell pool size, and identifying relevant cell-cell communications and secreted molecules involved in this fundamental process, in order to identify novel tools and targets to enhance stem cell-mediated tissue maintenance and repair.

PI_NAMEs: PURI, PIER LORENZO;SACCO, ALESSANDRA  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Adult;Aging;Blocking Antibodies;Cell Communication;Cell Count;Cell secretion;Cells;Cellular biology;Disease;Endothelial Cells;Gene Expression Profiling;Genetic Models;Goals;Growth;Human;Impairment;improved;Inflammatory;Injury;Ligase;Maintenance;Mediating;Mediator;Molecular;Mus;Muscle;muscle progenitor cell;Muscle satellite cell;Natural regeneration;novel;overexpression;Play;Process;progenitor;Proliferating;Proteome;Proteomics;Publications;Regenerative Medicine;repair function;repaired;Role;self-renewal;Signal Pathway;Signal Transduction;Skeletal Muscle;skeletal muscle growth;Source;stem cell function;stem cells;Stress;Techniques;Testing;tissue regeneration;tissue repair;Tissues;tool;transcriptome sequencing;ubiquitin-protein ligase;Up-Regulation;Validation;Work

PROJECT_TITLE: Role of Fbxw7-Mediated Proteasomal Degradation in Myofibers in Determining Muscle Stem Cell Pool Size


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: DAVIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative The proposed study will add to the evidence base to inform the design of interventions in low-income communities to support children to fulfill their developmental potential and to promote the development of human capital, broadly defined as the health, well-being, and productivity of populations. Evidence from this study could inform more effective targeting of risk factors for prevention, as well as promotion of protective factors, at the time points when they will most likely show positive impacts on children’s cognitive, social- emotional, and academic outcomes. This is in accordance with the United Nations’ Global Strategy for Women’s Children’s and Adolescents’ Health (2016-2030), which targets three pillars of survival (ending preventable deaths), thriving (ensuring health and well-being), and transformation (expanding enabling environments).

PI_NAMEs: HASTINGS, PAUL DAVID (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: 5 year old;adolescent health;adverse outcome;Age;Alzheimer's Disease;Anemia;Biological;Birth;Caregivers;Child;Child Development;Child Support;Childhood;Clinical Research;Cognitive;cognitive development;cohort;Communities;Competence;cost;Country;Data;Data Set;Development;Disease;dynamic system;early childhood;early life adversity;Emotional;Enrollment;Ensure;Environment;Etiology;evidence base;Evidence based program;executive function;experience;Exposure to;follow up assessment;Ghana;Goals;Growth;Health;Home;Home environment;human capital;Human Resources;Income;infancy;Informal Social Control;insight;International;Intervention;Investigation;Investments;kindergarten;Learning;Life Cycle Stages;Lipids;Longitudinal cohort;longitudinal dataset;low and middle-income countries;Low Birth Weight Infant;Low income;Malignant Neoplasms;maternal depression;Measures;Memory;Modeling;National Institute of Child Health and Human Development;Nursery Schools;Nutrient;Outcome;Participant;Pattern;Personal Satisfaction;Policies;Population;Poverty;preadolescence;Predictive Factor;Predisposition;Pregnancy;Premature Birth;prenatal;preventable death;Prevention;Prevention strategy;procedural memory;Productivity;prospective;protective factors;psychosocial;Research;resilience;Risk;Risk Factors;Sample Size;Sampling;Schools;Science;secondary analysis;Severities;Shapes;skills;social;Strategic Planning;System;Testing;theories;therapy design;Time;Transact;treatment strategy;United Nations;Woman

PROJECT_TITLE: Investigation of a new sequential multiple hit model to examine risk and resilience in a prospective longitudinal cohort of children in Ghana

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebral Palsy;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Dystonia;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Rehabilitation

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Children and young adults with cerebral palsy have involuntary movements and tight muscles, with limited relief from current therapies. We will develop a novel therapy based on electrical stimulation of the cerebellum, in patients with cerebral palsy, using a brain stimulator that can also record and store brain signals. We will study these brain signals, along with brain imaging, to better understand why movement is abnormal in cerebral palsy and to optimize benefit from this therapy.

PI_NAMEs: SAN LUCIANO, MARTA  (contact)

PROGRAM_OFFICER_NAME: ROBINSON SCHWARTZ, SARAH ELIZABETH

PROJECT_TERMS: Address;Affect;Age;Ataxia;Athetoid cerebral palsy;Autopsy;Basal Ganglia;basal ganglia injury;Bilateral;Brain;brain dysfunction;Brain Hypoxia-Ischemia;Brain imaging;candidate identification;Caregivers;Cell Nucleus;Cerebellar Cortex;Cerebellar Diseases;Cerebellum;Cerebral Palsy;Cervical Dystonia;Child;Childhood;choreoathetosis;Chronic;Clinical;Clinical assessments;Clinical Trials;Clinical Trials Design;Combined Modality Therapy;comorbidity;Complication;connectome;Data;Deep Brain Stimulation;Defect;Denervation;Dentate nucleus;Development;Diffusion;Diffusion Magnetic Resonance Imaging;disability;Disabling;Disease;Distal;Dorsal;Double-Blind Method;Dystonia;effective therapy;efficacy study;efficacy testing;Electric Stimulation;Etiology;evidence base;FDA approved;fetal;Frequencies;functional disability;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;Goals;Human;Image;imaging biomarker;imaging study;Impairment;Implant;improved;Individual;Infant;Injury;Involuntary Movements;kinematics;Lead;Lesion;Magnetic Resonance Imaging;Measures;Motor;Motor Manifestations;Movement;Movement Disorders;Mus;Muscle;Muscle Tonus;Mutation;neonatal hypoxic-ischemic brain injury;network models;neural;neural circuit;neuroimaging;neurophysiology;neuroregulation;Neurotoxins;neurotransmission;novel therapeutics;open label;Outcome;outcome prediction;Output;Participant;Pathway interactions;Patient Self-Report;Patients;Pattern;Periodicals;Personal Satisfaction;Persons;Pharmaceutical Preparations;pharmacologic;Phase;physically handicapped;Physiologic pulse;Physiological;Population;Postoperative Period;Posture;potential biomarker;Purkinje Cells;Quality of life;randomized, clinical trials;reduce symptoms;Reporting;response;Risk;Role;Safety;sample fixation;Secondary to;Severities;Severity of illness;Signal Transduction;Source;Spasm;spasticity;structural imaging;Structure;Syndrome;Technology;Thalamic structure;Therapeutic;treatment response;Videotape;wearable monitor;young adult

PROJECT_TITLE: Cerebellar deep brain stimulation for severe combined movement disorders and spasticity in children and young adults with cerebral palsy

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative HIV/HBV coinfection is associated with accelerated liver fibrosis progression, even in the face of viral suppression using antiviral drugs. By clarifying the mechanisms by which HIV accelerates HBV fibrogenesis, we will be able to take major steps toward defining new approaches to target the interruption and cure of HBV and its contribution to liver cirrhosis and liver cancer.

PI_NAMEs: CHUNG, RAYMOND T (contact);LIN, WENYU

PROGRAM_OFFICER_NAME: RADKE, JOSHUA BRYAN

PROJECT_TERMS: Acceleration;Address;analog;Animal Model;Animals;Anti-viral Agents;Anti-viral Therapy;Biogenesis;Biological Models;Blood;CCR5 gene;Cell Line;Cells;chemokine receptor;Chronic Hepatitis B;Circular DNA;Cirrhosis;co-infection;Coculture Techniques;Collaborations;CXCR4 gene;cytokine;Disease Progression;DNA biosynthesis;Down-Regulation;end stage liver disease;endoplasmic reticulum stress;entecavir;experience;fibrogenesis;Fibrosis;Gene Expression;Genetic Transcription;HBV Liver Disease;Hepatic Fibrogenesis;Hepatic Stellate Cell;Hepatitis B Virus;Hepatitis C co-infection;Hepatitis C virus;Hepatocyte;HepG2;HIV;HIV Envelope Protein gp120;HIV Infections;HIV-1;Human;humanized mouse;improved;In Vitro;in vivo;in vivo Model;insight;Interferon alpha;Interruption;Laboratories;Liver;Liver Cirrhosis;Liver diseases;Liver Fibrosis;liver inflammation;liver injury;Macrophage;Malignant neoplasm of liver;Mediator;Metabolic;mitochondrial metabolism;Modeling;mortality;mouse model;Na(+)-taurocholate-cotransporting peptide;novel;novel strategies;nuclease;Pathogenesis;Pathway interactions;Patients;Pegylated Interferon Alfa;Peripheral Blood Mononuclear Cell;Persons;PPAR alpha;prevent;Primary carcinoma of the liver cells;Production;Proteins;Pyruvate;Pyruvate Kinase;Pyruvate Metabolism Pathway;Reactive Oxygen Species;receptor;response;Serum;Signal Transduction;spheroids;Tenofovir;Testing;therapy design;therapy development;treatment comparison;Viral;Virus Diseases;virus host interaction;Virus Replication;vpr Gene Products

PROJECT_TITLE: Cooperative mechanisms of HIV-enhanced liver fibrogenesis in HBV Coinfection

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Neurosciences;Prostate Cancer;Urologic Diseases

ORG_CITY: Beaverton

ORG_NAME: TRACE BIOSCIENCES INC

ORG_STATE: OR

PHR: PROJECT NARRATIVE  Iatrogenic nerve injury is one of the most feared complications of surgery with up to 600,000 patients affected annually in the United States alone. At present, there is no technology to improve visual recognition of nerve tissue during surgery, leaving surgeons to rely largely on anatomical knowledge to locate small or buried nerves invisible to the naked eye. We have developed first-in-kind targeted near-infrared (NIR) fluorophores that label nerve tissue with high affinity for direct nerve visualization during fluorescence-guided surgery and completion of the proposed aims will establish pre-clinical testing of our lead compound towards first-in-human trials to significantly reduce iatrogenic nerve injury rates and revolutionize surgery as we know it.

PI_NAMEs: BARTH, CONNOR WILLIAM (contact)

PROGRAM_OFFICER_NAME: POND, MONIQUE ADRIANNE

PROJECT_TERMS: Acute;Affect;Affinity;Anatomy;Biodistribution;Blood;Body Weight;Canis familiaris;Chemicals;Clinical;Clinical Research;clinical translation;Clinical Trials;Contracts;Contrast Media;cross reactivity;design;Dose;Drug Kinetics;Excision;Eye;Family suidae;first-in-human;fluorescence-guided surgery;fluorophore;Formulation;Foundations;Freeze Drying;Fright;good laboratory practice;Human;Iatrogenesis;Image;Image-Guided Surgery;imaging system;improved;industry partner;Intravenous;Investigational Drugs;Investigational New Drug Application;Investments;Knowledge;Label;Laboratories;Lead;lead candidate;Libraries;Lifelong disability;Malignant Neoplasms;manufacture;Methods;Molecular Target;Mus;Nerve;nerve damage;nerve injury;Nerve Tissue;Nerve-Sparing Prostatectomy;Nerve-Sparing Surgery;neurotransmission;No-Observed-Adverse-Effect Level;operation;Operative Surgical Procedures;Patient-Focused Outcomes;Patients;Pharmacodynamics;pharmacologic;Pharmacologic Substance;Pharmacology;Pharmacology and Toxicology;Phase;pre-clinical;Preclinical Testing;preservation;Procedures;Radical Prostatectomy;Rattus;Rodent;Services;Solubility;Specificity;Specimen;Stains;Sterility;Strategic Planning;Structure-Activity Relationship;Surgeon;surgery outcome;Surgical complication;Technology;Testing;Time;tissue injury;Toxic effect;Toxicology;Translations;United States;Visual;Visualization;water solubility

PROJECT_TITLE: Clinical Translation of Near Infrared Nerve-Specific Fluorophores for Nerve-sparing Prostatectomy


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Cancer;Liver Disease;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Chronic liver disease often progresses to fibrosis, cirrhosis, and cancer, but treatments for advanced liver disease are limited. By demonstrating that hepatic progenitor cells are a novel cellular compartment that can be modulated to inhibit progression of fibrotic liver disease and to promote regeneration, the proposed work will reveal a number of disease-related targets and will serve as the basis for future translational strategies.

PI_NAMEs: SHIN, SOONA  (contact)

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: angiogenesis;Animal Model;Cell Proliferation;Cell secretion;Cells;cellular targeting;chronic liver disease;Cirrhosis;Data;diphtheria toxin receptor;Disease;Disease Progression;end stage liver disease;Endothelial Cells;Endothelium;epithelial stem cell;Experimental Models;Fibrosis;FOXL1 gene;Future;gain of function;Gene Expression;Hepatic;Hepatic Stellate Cell;Hepatocarcinogenesis;Hepatocyte;Human;improved;in vivo;innovation;Knowledge;Label;Liver;Liver diseases;Liver Fibrosis;liver function;Liver Regeneration;loss of function;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;Mediator;Molecular;Molecular Profiling;Morphology;mouse model;Mus;Natural regeneration;new therapeutic target;notch protein;Notch Signaling Pathway;novel;paracrine;Pathogenesis;Pathogenicity;Pathway interactions;programs;Proliferating;Reaction;Reporting;Risk;Risk Factors;Role;severe injury;Signal Transduction;stellate cell;stem cells;Testing;Transgenic Organisms;translational approach;translational study;tumorigenesis;Work

PROJECT_TITLE: Pathogenic Role of Foxl1+ Hepatic Progenitor Cells in Fibrotic Liver Disease


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Cell-autonomous circadian biological clocks work in all cells of the human body to regulate metabolism, and their influence is prominent in adipocytes. By studying adipocyte circadian cell biology in pure cells in culture in the absence of organismal cues, we can understand how clock control works in this important cell type, and potentially learn how clock control may be used to understand and address issues of metabolic syndrome and obesity.

PI_NAMEs: FREDERICK, ARMINA-LYN M (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Address;adipocyte biology;adipocyte differentiation;Adipocytes;Adipose tissue;Adopted;Affect;Binding;Bioenergetics;bioinformatics tool;Biological Clocks;Biology;Bypass;Cell Physiology;cell type;Cells;Cellular biology;Cessation of life;Chronic;Chronic Disease;circadian;circadian biology;circadian pacemaker;circadian regulation;Circadian Rhythms;Confocal Microscopy;Coupled;Creatine;Cues;Data;differentiation in vitro;Disease;Elements;Energy Metabolism;Enzymes;Epidemic;Feedback;Fluorescence;Functional disorder;Futile Cycling;Gene Expression Profiling;Genes;Genetic Transcription;Genomics;glucose metabolism;Goals;Homeostasis;Hour;Human body;Hyperplasia;Hypertrophy;Image;Learning;Light;Link;lipid metabolism;Lipids;live cell microscopy;luminescence;Mediating;Messenger RNA;Metabolic;Metabolic Control;Metabolic syndrome;Metabolism;Mitochondria;Molecular;Monitor;Morphology;Mus;Nutrient;Obesity;Oligomycins;Organelles;Output;Pathway interactions;Pattern;Periodicity;Phase;Phenotype;Physiological;Physiology;postmitotic;Process;Production;Protons;Purine Nucleotides;Research;Resolution;Respiration;Risk;Risk Factors;Role;Sleep Wake Cycle;Stimulus;System;Systems Biology;Temperature;Testing;Thermogenesis;Time;Tissues;transcriptome sequencing;uncoupling protein 1;Vision;Weight;Western Blotting;Work

PROJECT_TITLE: Circadian Regulation of In Vitro Differentiated Adipocytes


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebral Palsy;Clinical Research;Data Science;Disability Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Rehabilitation;Social Determinants of Health

PHR: Project Narrative The proposed project innovatively applies machine learning methods to retrospective electronic  health record and prospective clinical data to develop a precision health model for cerebral  palsy-related phenotypes, health status, care activities, and psychosocial well-being that will  individualize care. This project will move the field toward precision medicine for cerebral palsy  and create a foundation for development of electronic health record-based clinical practice tools.  The proposed research is highly relevant to the NIH mission to understand and enhance the lives of  children and optimize abilities for all.

PI_NAMEs: ARONOW, BRUCE J;BAILES, AMY ;KUROWSKI, BRAD G (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Acceleration;Address;Affect;Age;Algorithms;Big Data;biopsychosocial;care delivery;Caring;Cerebral Palsy;Characteristics;Child;Childhood;Classification;Clinical;clinical care;Clinical Data;clinical development;clinical phenotype;clinical practice;Clinical Practice Guideline;cohort;Collaborations;Collection;Complex;dashboard;Data;data modeling;data repository;database query;Descriptor;design;Development;Diagnosis;Dimensions;Electronic Health Record;electronic structure;Environmental Risk Factor;evidence base;Evidence based practice;Exhibits;Family;Foundations;functional outcomes;functional status;Future;Health;Health Status;Health system;Image;Impairment;improved;Individual;individual response;innovation;Institution;Intervention;Learning;Life;Literature;Machine Learning;machine learning algorithm;machine learning method;machine learning model;Medical center;Methods;Mission;Modeling;Motor;Motor Skills;Movement;Natural Language Processing;novel;Outcome;Patients;Patterns of Care;personalized care;Pharmaceutical Preparations;Phenotype;physically handicapped;Population Distributions;Precision Health;precision medicine;Procedures;prospective;Prospective cohort;Protocols documentation;prototype;psychosocial;psychosocial wellbeing;Quality of life;Recommendation;recruit;Research;Resolution;Severities;Socioeconomic Factors;Standardization;Subgroup;System;Testing;Time;tool;Translating;treatment response;United States National Institutes of Health;Walking;Wheelchairs;Work

PROJECT_TITLE: Leveraging the electronic health record to characterize and optimize care delivery for children with cerebral palsy.

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: DURHAM

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative DNA replication problems collectively known as replication stress are a major source of genomic instability in cancer cells and also a vulnerability of cancer that can be exploited therapeutically. We will systematically define and characterize different types of replication stress and the resulting vulnerabilities, investigate the impacts of RNA on DNA replication and repair, and explore the cell non-autonomous effects of replication stress, building a new molecular basis for exploiting replication stress in cancer therapy.

PI_NAMEs: ZOU, LEE  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Affect;anti-cancer research;ATR checkpoint;biological adaptation to stress;cancer cell;cancer genome;cancer therapy;Cells;DNA biosynthesis;DNA Repair;Event;Genetic Transcription;Genome;Genomic Instability;Human;interest;Malignant Neoplasms;Modeling;Molecular;mutant;Oncogenic;Pathway interactions;Poly(ADP-ribose) Polymerase Inhibitor;Population;Regulation;repaired;replication stress;RNA;Signal Transduction;Source;Stress;success;targeted treatment;Therapeutic;Transcript;tumor;tumor microenvironment;Work

PROJECT_TITLE: Understanding and targeting the DNA replication stress in cancer cells


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Genetic Testing;Genetics;Orphan Drug;Ovarian Cancer;Precision Medicine;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE This translational study is expected to provide information on cancer risks that is needed for the development of clinical management strategies for women with RAD51C and RAD51D mutations. In addition, determination of the cancer risks and responsiveness to targeted therapy associated with many RAD51C and RAD51D VUS will allow patients with these alterations to benefit from improved risk management and potentially targeted treatment. Similarly, evaluation of the efficacy of combination therapies for RAD51C and RAD51D deficient tumors may lead to development of clinical trials and novel therapeutic strategies for those with germline or somatic mutations in these genes.

PI_NAMEs: COUCH, FERGUS JOSEPH (contact);WEROHA, SARAVUT

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: age related;Biochemical;BRCA1 gene;BRCA1 Mutation;BRCA2 gene;BRCA2 Mutation;Breast Cancer Early Detection;Breast Cancer gene;Breast Cancer Risk Factor;Cancer Patient;cancer predisposition;cancer risk;cancer subtypes;case control;Case/Control Studies;Cell Line;Cells;Cisplatin;Classification;Clinical;clinical care;clinical development;clinical efficacy;Clinical Management;Clinical Trials;clinically relevant;cohort;Combined Modality Therapy;Correlative Study;CRISPR/Cas technology;defined contribution;DNA Repair;Drug Targeting;early screening;effective therapy;efficacy evaluation;Exhibits;Family;Family history of;Family member;Gene Silencing;General Population;Genes;Genetic study;genetic testing;Genotype;Germ Lines;Germ-Line Mutation;Guidelines;Heritability;high risk;high risk population;High Risk Woman;homologous recombination;improved;Individual;Inherited;inhibitor therapy;insight;Intervention;Learning;lifetime risk;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammary Neoplasms;Mastectomy;Medical Genetics;Mutation;mutation carrier;National Comprehensive Cancer Network;novel;novel therapeutic intervention;Oncogenes;ovarian neoplasm;Ovariectomy;PARP inhibition;Pathogenicity;patient derived xenograft model;Patients;Phenotype;Platinum Compounds;Poly(ADP-ribose) Polymerase Inhibitor;population based;Pre-Clinical Model;precision medicine;predicting response;predictive marker;Predisposition;Property;prophylactic;prophylactic mastectomy;protein function;Proteins;Qualifying;RAD51C gene;recombinational repair;Recommendation;Resistance;response;Risk;Risk Assessment;Risk Estimate;Risk Management;Role;Signal Pathway;Somatic Mutation;Susceptibility Gene;targeted treatment;Test Result;Testing;Therapeutic Agents;translational study;Treatment Efficacy;treatment response;triple-negative invasive breast carcinoma;tumor;Variant;variant of unknown significance;Woman

PROJECT_TITLE: The contribution of RAD51C and RAD51D to breast and ovarian cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: Proactive goals of care conversations (GoCCs) are a hallmark of high-quality, patient-centered care, allowing healthcare providers to tailor end-of-life care to patient values. When done well, GoCCs improve outcomes for patients, family/caregivers, providers, and healthcare systems. Unfortunately, proactive GoCCs remain vastly underutilized. The emergence of the COVID-19 pandemic in March 2020 and its disruption to healthcare emphasized the need for explicit GoCCs to elicit patient goals and preferences. This study will assess how the pandemic disrupted implementation of VA’s Life-Sustaining Treatment Decisions Initiative (LSTDI), a standardized approach to conducting and documenting GoCCs. We will evaluate how COVID affected rates of GoCCs during [and after] the pandemic and catalyzed innovations to the LSTDI. We will identify [sustainable] best practices to improve frequency, quality, and equity of outpatient GoCCs that remain relevant post- pandemic and create a highly usable playbook to improve LSTDI implementation at low-performing VA sites.

PI_NAMEs: LINSKY, AMY  (contact);WIENER, RENDA SOYLEMEZ

PROJECT_TERMS: Advance Care Planning;Affect;Attention;Black race;Caregivers;Caring;catalyst;Cessation of life;Characteristics;Clinical;clinical risk;COVID-19;COVID-19 impact;COVID-19 pandemic;Dementia;design;Deterioration;Development;Disparity;Documentation;Effectiveness;end of life care;Ensure;Equity;Ethics;Evaluation;experience;Family;Frequencies;Goals;Guidelines;hazard;health care delivery;Health Personnel;Healthcare;Healthcare Systems;high risk;implementation framework;implementation science;implementation strategy;improved;improved outcome;innovation;Interruption;Interview;Learning;Length;Life;long term COVID-19 pandemic impacts;long-standing disparities;Measures;Methods;Modality;novel;Outcome;Outpatients;outreach;pandemic disease;pandemic disruption;patient oriented;Patient-Centered Care;Patient-Focused Outcomes;Patients;post-pandemic;pre-pandemic;preference;Primary Care;Process;Provider;provider adoption;Quality of Life Assessment;Racial Equity;response;Series;shared decision making;Site;Specific qualifier value;Standardization;Structure;surrogate decision maker;telehealth;Time;Time Series Analysis;Training;uptake;usability;Variant;Veterans;Work

PROJECT_TITLE: Impact of COVID-19 on implementation and outcomes of VA's Life-Sustaining TreatmentDecisions Initiative

STUDY_SECTION_NAME: HSR-6 Aging, Recovery, and Workforce[HSR6]


ORG_CITY: BURLINGTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE Reproductive health issues as serious as miscarriage, birth defects, and the loss of fertility due to advancing age or exposure to gonadotoxic agents can frequently be traced back to a decline in oocyte quality and/or quantity. We have discovered that the noncoding RNAs H19 and let-7 regulate genes involved in follicular recruitment and DNA repair, processes whose regulation is essential for the maintenance and growth of an adequate population of healthy oocytes. Our proposed studies have the potential to define noncoding RNAs as major regulators of ovarian reserve, and are directly related to the NIH Fertility and Infertility Branch’s mission of supporting research that enhances our understanding of normal reproduction and reproductive pathophysiology.

PI_NAMEs: KALLEN, AMANDA NICOLE (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Acceleration;Address;Age;Aging;Aneuploidy;Area;Back;Binding;Binding Sites;Birth Rate;Cells;chemotherapeutic agent;Child;child bearing;Congenital Abnormality;Data;Defect;Deterioration;Development;DNA Damage;DNA Repair;DNA Repair Gene;Doxorubicin;early pregnancy loss;Elderly;Estradiol;Estrogens;Etiology;Exposure to;Fertility;fetal loss;folliculogenesis;Functional disorder;Gatekeeping;Genes;Genomics;Germ Cells;granulosa cell;Growth;H19 gene;Health;Hormones;In Vitro;Infertility;innovation;insight;Investigation;Link;Long-Term Effects;Maintenance;Maternal Age;Maternal Health;Mediating;Messenger RNA;MicroRNAs;Mission;Molecular;Mothers;mullerian-inhibiting hormone;Mus;National Institute of Child Health and Human Development;non-genomic;novel;offspring;oocyte quality;Oocytes;Ovarian;Ovarian aging;Ovarian Follicle;ovarian reserve;Ovary;Pathway interactions;Physiology;Play;Population;Predisposition;Pregnancy loss;Premature Menopause;primary ovarian insufficiency;Primordial Follicle;Process;Production;Public Health;recruit;Regulation;Regulatory Pathway;repaired;Reproduction;reproductive;Reproductive Health;reproductive outcome;reproductive senescence;reproductive system disorder;Research Priority;Research Support;response;RNA Interference;Role;Signal Pathway;Somatic Cell;Spontaneous abortion;Testing;Therapeutic;Time;Tissues;transcriptome;United States National Institutes of Health;Untranslated RNA;Woman;Women's Health;Work

PROJECT_TITLE: The Regulation of Ovarian Aging by H19 and let-7

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Mycobacterium tuberculosis (Mtb), the causative agent of the disease tuberculosis (TB), is estimated to infect one-fourth of the world's population, resulting in approximately 1.6 million deaths each year. There is a critical need to better understand the mechanisms of TB immunopathogenesis, as such mechanisms can be targeted to improve host control of Mtb infection. At the completion of the aims proposed here, we would have considerably expanded our understanding of the Mtb-specific signaling pathways and factors that positively and negatively regulate Myeloid Derived Suppressor Cell accumulation and activation during TB. Additionally, our translational studies in NHPs will enable progression of HDTs to limit MDSCs during TB. The knowledge to be gained from these studies is significant, as it will advance the development of new therapeutics for limiting TB reactivation and progression to TB.

PI_NAMEs: KAUSHAL, DEEPAK ;KHADER, SHABAANA A. (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Advanced Development;Animal Model;Automobile Driving;B-Lymphocytes;BCG Live;Bronchus-Associated Lymphoid Tissue;cell type;Cessation of life;Characteristics;Chronic;Clinical;comparison control;cytokine;Data;Disease;Drug resistant Mycobacteria Tuberculosis;extensive drug resistance;Genes;Granuloma;Human;Hypoxia Inducible Factor;IL17 gene;Immunity;Immunologics;improved;in vivo;Infection Control;Infiltration;Inflammatory;inhibitor;Knowledge;Lung;Macaca;Mediating;Modeling;Molecular;mouse model;Mus;Mycobacterium bovis;Mycobacterium tuberculosis;Myeloid Cells;Myeloid-derived suppressor cells;neutrophil;nonhuman primate;novel therapeutics;Pathology;Pathway interactions;Pharmaceutical Preparations;Population;Predisposition;prevent;Production;Proteins;Publishing;Pulmonary Tuberculosis;Relapse;Role;S100A8 gene;Signal Pathway;Signal Transduction;T cell response;T-Lymphocyte;Therapeutic;transcription factor;translational study;Translations;Tretinoin;Tuberculosis;tuberculosis treatment;Vaccines

PROJECT_TITLE: Understanding the functional role of Myeloid Derived Suppressor cells in tuberculosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AARR-P(02)]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Clinical Research;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: NARRATIVE Various types of immune cells are involved in the development and progression of multiple sclerosis, including several types of Th cells. We, and others, have recently described a new type of Th cells designated here as “ThGM” cells. We propose to characterize different aspects of ThGM cell biology and the role of these cells in autoimmune neuroinflammation, a study that may lead to novel therapies for multiple sclerosis and other autoimmune diseases.

PI_NAMEs: ROSTAMI, A.M.  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Address;Autoimmune;Autoimmune Diseases;Autoimmunity;Binding;Biology;Blood;Brain;CCL20 gene;CD4 Positive T Lymphocytes;Cell Lineage;Cell secretion;Cell Shape;Cells;Cellular biology;Cerebrospinal Fluid;Classification;CNS autoimmunity;Complex;cytokine;Data;Development;differential expression;Disease;Experimental Autoimmune Encephalomyelitis;Future;Gene Expression Profile;Granulocyte-Macrophage Colony-Stimulating Factor;Health;Human;Immune;immune system function;Immunity;In Vitro;in vivo;Individual;Inflammation;Interleukin-2;knock-down;Knockout Mice;Knowledge;Lesion;Mediator;Membrane;Modeling;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;multiple sclerosis treatment;Mus;Myeloid Cells;Names;Nature;neuroinflammation;novel therapeutic intervention;novel therapeutics;overexpression;Pathogenesis;Pathogenicity;Peripheral Blood Mononuclear Cell;Phenotype;Physiological;Play;Population;Process;Production;Proteome;Publishing;Role;Shapes;single-cell RNA sequencing;Slice;System;T-Lymphocyte;Testing;TNF gene;TNFSF6 gene;transcription factor;transcriptome

PROJECT_TITLE: ThGM Cells in CNS Autoimmunity

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Bioengineering;Genetics;Nanotechnology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Heterotopic ossification (HO) is the pathologic formation of extra-skeletal bone that forms almost exclusively after an injury with a large inflammatory response. We purport that increased JMJD3 in tissue macrophages increases TGFꞵ1, which promotes an osteochondral phenotype in mesenchymal progenitor cells and results in HO. This proposal will seek to understand the mechanisms responsible for the altered JMJD3/TGFꞵ1 signaling and will test new cell-targeted nanotherapies to restore cell homeostasis enable us to combat this currently untreatable disease.

PI_NAMEs: GALLAGHER, KATHERINE ANN (contact);LEVI, BENJAMIN

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Animal Model;bone;Burn injury;Cell Lineage;Cells;Chromatin;clinically relevant;combat;Data;Development;Disease;Elements;Enzymes;Epigenetic Process;epigenetic regulation;experimental study;Gene Expression;Genes;Genetic;genetic approach;Genetic Transcription;Heterotopic Ossification;hip replacement arthroplasty;histone demethylase;histone modification;Homeostasis;Human;Immune response;in vivo;Inflammatory;Inflammatory Response;inhibitor;injured;Injury;insight;Interferon-beta;JAK1 gene;Janus kinase;Kinetics;Laboratories;Macrophage;Mediating;Mesenchymal;Mesenchymal Stem Cells;Methods;Modeling;Modification;Molecular;mouse model;Mus;musculoskeletal injury;Myelogenous;nanoparticle;nanoparticle delivery;nanotherapeutic;nanotherapy;new therapeutic target;Normal tissue morphology;novel;osteochondral tissue;paracrine;Pathologic;Pathway interactions;Patients;pharmacologic;Phenotype;Physical therapy;Physiologic Ossification;pre-clinical;prevent;Preventive;Process;Production;programs;promoter;Protocols documentation;Publishing;Regulation;repaired;Repression;Role;Secondary to;Signal Pathway;Signal Transduction;Site;Specificity;STAT protein;STAT3 gene;stem cell differentiation;stem cell fate;stem cells;System;targeted treatment;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;therapeutic nanoparticles;therapy design;tissue repair;Tissues;Transforming Growth Factor beta;Trauma;Treatment Efficacy;Work;wound;wound healing

PROJECT_TITLE: Targeting jmjd3 mitigates heterotopic ossification

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lyme Disease;Prevention;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: COLLEGE PARK

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE Prevention of Lyme disease remains a challenge because of a lack of human vaccines and the frequent presence of chronic symptoms after standard-care antibiotics. This project will develop next-generation Rabies-based vaccine platforms based on a novel strategy utilizing unique spirochete and tick antigens, which facilitates transmission and infectivity of Lyme disease pathogens in the mammalian host.

PI_NAMEs: PAL, UTPAL  (contact);SCHNELL, MATTHIAS JOHANNES

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Animal Model;Antibiotic Therapy;Antibiotics;Antibody Response;Antigens;antimicrobial;Attenuated;Biology;Black-legged Tick;Borrelia;Borrelia burgdorferi;Borrelia burgdorferi Group;Chronic;Clinical;cohort;combat;Communicable Diseases;Complementary DNA;Complex;Cultured Cells;Data;design;Development;Diagnosis;Disease;enzootic;experience;extracellular;FDA approved;Goals;Human;Immune response;Immunity;Immunization;Immunize;immunogenicity;Inactivated Vaccines;Incidence;Infection;Infection Control;Intervention;Laboratories;Lyme Disease;Lyme Disease Vaccines;Mammals;Marketing;Measures;Mediating;Membrane;Membrane Proteins;Methods;Microbe;microbial;microorganism antigen;mouse model;Nature;neutralizing antibody;next generation;novel;novel strategies;novel vaccines;Order Spirochaetales;OspA protein;Oxidases;pathogen;Pathogenesis;pathogenic bacteria;patient subsets;Patients;persistent symptom;Post Treatment Lyme Disease Syndrome;preclinical study;prevent;Prevention;Prevention strategy;Preventive measure;Proteins;Publishing;Rabies;Rabies virus;Recombinant Proteins;Recombinants;Relapse;Research Priority;response;reverse genetics;Rodent;Role;Safety;Sales;Series;Set protein;Spirochaetales Infections;standard care;Surface;Symptoms;System;Tick Infestations;tick transmission;Tick-Borne Diseases;Tick-Borne Infections;Ticks;Transfection;transmission process;United States;Vaccination;vaccination strategy;vaccine candidate;vaccine development;vaccine platform;Vaccines;vector;vector tick;vector vaccine;Viral Vector;Virion;Virus Diseases;Virus-like particle

PROJECT_TITLE: Multivalent Tick-Microbe targeted Lyme disease vaccines

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-R(02)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Towards Multiplex Precision Genome Engineering Technology Beyond CRISPR As medicine advances to unravel mechanisms of complex human diseases such as cancer, auto-immune diseases, and neuro-degeneration, a remaining challenge is that our knowledge of the genetic and epigenetic basis of these disorders are often limited to small genome changes like single-nucleotide variants. The key bottleneck for uncover these genome black boxes is the lack the precision tools to study large genome changes. Thus, it demands new modalities of multiplexable and accurate genome engineering tools that we proposes to develop here, leveraging advances in computational modeling and genome editing, to push our ability to engineer, track, and control cellular genome, with cancer model as initial test ground.

PI_NAMEs: CONG, LE  (contact)

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Autoimmune Diseases;Bar Codes;Biological Models;Black Box;Cancer Model;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Complex;Computational Technique;Computer Models;CRISPR/Cas technology;design;Disease;DNA;Drug resistance;Engineering;Epigenetic Process;gene editing technology;Genetic;Genetic Recombination;genetic variant;Genome;genome editing;Genome engineering;genomic locus;Goals;Human;human disease;Human Genome;improved;In Vitro;in vivo;Knowledge;Malignant Neoplasms;mammalian genome;Medicine;Methods;microbial;Modality;Modification;Nerve Degeneration;Proteins;Resolution;RNA;single cell genomics;Single Nucleotide Polymorphism;success;System;Technology;Testing;Therapeutic;tool;Toxic effect;tumor;Variant;Work

PROJECT_TITLE: Towards Robust Multiplex Genome Engineering Beyond CRISPR-Cas9


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: The Medical Student Research Program in Eye Health and Disease at the University of Utah School of Medicine will nurture and build the physician-scientist workforce of tomorrow through mentored summer research experiences and an innovative course in creative and critical thinking that focuses on eye-related research.

PI_NAMEs: ANGELUCCI, ALESSANDRA  (contact);STAGG, BRIAN

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TITLE: Medical Student Research Program (MSRP) in Eye Health and Disease


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Prevention;Primary Health Care;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Postpartum depression impacts 1 in 8 women with a live birth and has well-documented negative effects on maternal and infant health. In this K01, Dr. Gordon will evaluate how postpartum Medicaid policies affect screening, diagnosis, and treatment for postpartum depression among low-income mothers in the postpartum year, contributing timely and policy-relevant evidence to reduce income-based disparities in maternal mental health. Dr. Gordon's mentorship team and training in the delivery of mental health services, mixed-methods research, qualitative methods, and tools to measure and map area-level variation in policy effects will support her goal of becoming an independent mental health services researcher focusing on access to mental health care among low-income populations.

PI_NAMEs: GORDON, SARAH HALL (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Affect;American;Anxiety;Area;behavioral health;Birth;Birth Certificates;Birth Records;Boston;Breast Feeding;Caring;Child;Cluster Analysis;Colorado;County;Data;Data Analyses;Data Collection;Data Set;Databases;Depression screen;depressive symptoms;design;Detection;Developmental Delay Disorders;Diagnosis;Disparity;Economically Deprived Population;effective intervention;Eligibility Determination;Enrollment;experience;Feeling suicidal;Focus Groups;Geography;Goals;health care disparity;Health Services Accessibility;Healthcare;Heterogeneity;improved;Income;Individual;Infant;Infant Health;informant;Insurance;Insurance Coverage;Intervention;Interview;Link;Live Birth;Long-Term Depression;Low income;Low Income Population;Maps;maternal depression;Maternal Health;maternal morbidity;Maternal Mortality;Measures;Medicaid;Medicaid eligibility;Mental Depression;Mental Health;mental health policy;Mental Health Services;Mentorship;Methods;Mothers;multilevel analysis;multiple data sources;National Institute of Mental Health;novel;Patients;perinatal mental health;perinatal period;perinatal women;pharmacologic;Phase;Policies;Policy Analysis;Policy Making;Postpartum Depression;Postpartum Period;Postpartum Women;Poverty;Pregnancy;Pregnancy Complications;Privatization;professor;Provider;Public Health;Public Health Schools;Qualitative Methods;Qualitative Research;Research;Research Methodology;Research Personnel;Research Priority;Risk;rurality;Sampling;Schools;screening;Services;skill acquisition;skills;socioeconomic disadvantage;Strategic Planning;substance use;suicidal act;Symptoms;Techniques;Testing;tool;Training;Underserved Population;Universities;Variant;Well Child Visits;Woman;women's outcomes;Work

PROJECT_TITLE: The Effects of Postpartum Medicaid Policies on Postpartum Depression Care Among Low-Income Women

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Human Genome;Kidney Disease;Patient Safety;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE There are 500 million people worldwide with chronic kidney disease, and it disproportionately affects older adults. Our goal is to integrate multi-omics data to elucidate biological pathways underlying chronic kidney disease risk with the purpose of improving risk prediction, prevention, and prognosis.

PI_NAMEs: CORESH, JOSEF ;GRAMS, MORGAN ERIKA (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Address;adjudication;Adult;Adverse event;adverse outcome;Affect;Age;age related;age related changes;aged;Albumins;Albuminuria;Ancillary Study;Area;atherosclerosis risk;Atherosclerosis Risk in Communities;Benign;Biological;Biological Markers;Blood;Cardiac;Cardiovascular Diseases;Caring;Case/Control Studies;Cessation of life;Chronic Kidney Failure;Clinical;clinical risk;clinically relevant;cohort;Communities;Complex;CpG dinucleotide;Creatinine;Data;Disease;Disease Outcome;disease prognosis;Disease Progression;disorder risk;DNA;DNA Methylation;drug development;Drug Targeting;Echocardiography;End stage renal failure;Environmental Exposure;Epigenetic Process;epigenetic variation;epigenome-wide association studies;epigenomics;Etiology;Event;experience;Fibrosis;Filtration;Functional disorder;Funding;Funding Mechanisms;Gene Expression;Genes;Genetic;genetic variant;Genetic Variation;genome wide association study;Goals;Grant;Heart failure;heart function;Heterogeneity;high risk;high throughput technology;Hospitalization;Hour;improved;Individual;Inflammation;innovation;insight;interest;Intervention;Kidney;Letters;Longterm Follow-up;Measures;Mendelian randomization;Metabolic;metabolomics;Methods;Methylation;methylation pattern;Molecular;mortality;Multiomic Data;National Institute of Diabetes and Digestive and Kidney Diseases;Network-based;novel;older adult;Outcome;Participant;Pathogenesis;Pathway Analysis;Pathway interactions;Patients;Persons;Phenotype;Physiology;Population;prevent;Prevention;Production;Prognosis;Proteins;Proteomics;Renal function;Research Priority;Risk;Risk Factors;risk prediction;Series;Signal Transduction;Site;Systems Biology;Techniques;therapeutic target;therapy development;Tissues;Urine;Variant;Visit

PROJECT_TITLE: Integrative Omics, Chronic Kidney Disease, and Adverse Outcomes in Older Adults

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Immunization;Immunotherapy;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Narrative In the present proposal, we will design a novel combination strategy for vaccine mediated ex vivo T cell expansion that promotes the expansion of central memory cells, enhances the activation and expansion of functionally dominant clones, and reverses critical mediators of the immunosuppressive milieu through TGFβ inhibition. Patient specific DC/AML fusions will be used to interrogate the relative dominance of T cell clones targeting individual neoantigens. In third aim, we will translate the preclinical findings into a phase I clinical trial and study the correlation between the characteristics of the T cell product with toxicity, in vivo activation, expansion, and persistence, and protection from relapse.

PI_NAMEs: AVIGAN, DAVID E. (contact);ROSENBLATT, JACALYN

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Active Immunization;Adoptive Immunotherapy;Adoptive Transfer;Age;Antigen Targeting;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Area;Autologous;Autologous Dendritic Cells;Beds;biomarker identification;Bone Marrow;CD28 gene;CD3 Antigens;Cell fusion;Cells;Cellular immunotherapy;Characteristics;chemokine;chemotherapy;chimeric antigen receptor T cells;Clinical Research;Clonal Expansion;Clone Cells;Correlation Studies;Dendritic Cells;design;Development;Disease;Disease remission;Effector Cell;Elements;exhaust;exhaustion;follow-up;Fostering;Functional disorder;Generations;Hematopoietic;Heterogeneity;IL7 gene;Immune;Immunocompetent;immunogenicity;Immunologic Surveillance;in vivo;Individual;Infiltration;Infusion procedures;Interleukin-15;Investigation;leukemia;Leukemic Cell;Ligation;long term memory;MADH2 gene;Malignant - descriptor;Malignant lymphoid neoplasm;Mediating;Mediator;Memory;migration;Modeling;Mus;Nature;neoantigens;neoplastic cell;novel;novel strategies;Pathway interactions;Patients;peripheral blood;personalized cancer vaccines;phase 1 study;Phase I Clinical Trials;Phase II Clinical Trials;Phenotype;Population;pre-clinical;prevent;Recurrence;Relapse;Reporting;response;restoration;senescence;T cell therapy;T-Cell Activation;T-Lymphocyte;Time;Toxic effect;transcriptome;Transforming Growth Factor beta;Translating;tumor;tumor heterogeneity;tumor microenvironment;Vaccination;vaccine efficacy;vaccine platform;vaccine response;vaccine strategy;Vaccine Therapy;Vaccines

PROJECT_TITLE: Personalized Adoptive T-cell Therapy for AML

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LEXINGTON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Cytochrome P450-1B1 (CYP1B1) is absent or expressed at very low levels in the liver and healthy tissues while being overexpressed in tumors, giving it the title of “universal tumor antigen”. Evidence from basic science, clinical, and epidemiological studies demonstrate that CYP1B1 is involved in cancer initiation, progression, and resistance to a wide range of chemotherapeutics. This work will define how CYP1B1 subcellular localization, oligomerization, degradation, and small molecule binding are altered in cancer cells as a function of specific single nucleotide polymorphisms (SNPs) and environmental factors, facilitating malignant progression, and will provide a new paradigm for small molecule inhibitors of the enzyme that function by inducing CYP1B1 protein degradation.

PI_NAMEs: GLAZER, EDITH C;HEIDARY, DAVID ;RICHARDS, CHRISTOPHER I (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: 3-Dimensional;Affect;Aromatase;Aromatase Inhibitors;Basic Science;Binding;Biology;Biotinylation;cancer cell;cancer initiation;Cell Line;Cell Physiology;Cells;chemotherapy;Chimeric Proteins;Cisplatin;Clinical Research;CYP17A1 gene;CYP1B1 gene;Cytochrome a;Cytochrome P450;Data;Disease;Dose;Drug resistance;efficacy evaluation;Environment;Environmental Risk Factor;enzyme activity;Enzyme Inhibitor Drugs;Enzymes;epidemiology study;experimental study;fluorescence lifetime imaging;Functional disorder;Generations;Genetic;Genetic Polymorphism;Goals;Half-Life;Heme;Hemeproteins;Homo;Hormones;Hydrophthalmos;Hypoxia;Immune response;improved;In Vitro;in vivo;Inherited;inhibitor;Iron;knock-down;Life Cycle Stages;Liver;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Medical;Membrane;Metabolic;Metabolic Diseases;Methods;Microscopy;Mitochondria;mitochondrial membrane;Modeling;Molecular;Molecular Conformation;monomer;Mutagens;Mutation;Mycoses;nanoscale;novel;Nucleotides;overexpression;Paclitaxel;Patients;pharmacologic;Phase I Clinical Trials;Phenotype;Photobleaching;Physiologic pulse;Play;Point Mutation;Population;Population Distributions;protein degradation;Protein Degradation Induction;protein protein interaction;Proteins;Proteolysis;residence;Resistance;Resolution;response;restoration;Role;Scanning;single molecule;Single Nucleotide Polymorphism;small molecule;small molecule inhibitor;spheroids;Testing;Therapeutic;Thermodynamics;Time;Tissues;trafficking;Treatment Efficacy;tumor;Tumor Antigens;tumor progression;Vesicle;Work

PROJECT_TITLE: Role of small molecule interactions and multiprotein assemblies in CYP1B1 disease-associated function and dysfunction

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Physical Injury - Accidents and Adverse Effects;Rheumatoid Arthritis

ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: RELEVANCE Fracture nonunion poses a significant clinical problem and its treatment usually involves complicated and massive procedures in practice, and sometimes needs multiple surgeries, therefore increases the cost of health care and results in marked patient disability. The proposed studies will enhance our understanding of mechanisms by which systemic inflammation (via the NF-κB pathway) affects the angiogenic process through Dnmt3b. This work will establish an important therapeutic option to improve the angiogenesis and fracture healing.

PI_NAMEs: GUAN, JIANJUN ;SHEN, JIE  (contact)

PROJECT_TERMS: Acceleration;Address;Affect;angiogenesis;Biocompatible Materials;biodegradable scaffold;Bone callus;bone fracture repair;cell motility;Cell Physiology;Cells;chemokine;Chondrocytes;Chronic;Clinical;Clinical Research;comorbidity;cytokine;Data;Defect;Diabetes Mellitus;diabetic;disability;Disease;DNA Methylation;DNA Modification Methylases;DNMT3B gene;Down-Regulation;efficacy evaluation;Endothelial Cells;Enzymes;Epigenetic Process;epigenome;experience;Failure;Fracture;gain of function;Gene Expression;healing;Health Care Costs;Human;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;Interleukin-1 beta;K/BxN model;Kinetics;Knowledge;Ligands;loss of function;Mediating;Methylation;Molecular;Mus;novel;novel therapeutic intervention;older patient;Operative Surgical Procedures;osteopontin;Pathway interactions;Patients;pharmacologic;Population;Procedures;Process;protective effect;restoration;Rheumatoid Arthritis;Role;scaffold;Serum;Signal Transduction;Smoking;systemic inflammatory response;Therapeutic;Therapeutic Effect;Therapeutic Intervention;therapeutically effective;Tube;United States;Work

PROJECT_TITLE: Targeting angiogenesis for fracture nonunion treatment under inflammatory diseases


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Networking and Information Technology R&D (NITRD);Neurosciences;Rare Diseases

ORG_CITY: LYME

ORG_NAME: INSIGHT SURGICAL TECHNOLOGIES INC.

PHR: PROJECT NARRATIVE In this Phase II proposal, we will leverage impressive Phase I feasibility results to research and develop the I2UpdateTM software product platform as a commercial GPU-grade software system with concomitant design control, software validation, procedural use and quality systems sufficient for FDA regulatory filing in the future, accompanied by in vivo animal validation and multi-site, multi-surgeon use demonstrating clinically-relevant and acceptable image-updating performance in terms of ease-of-use, efficiency and accuracy.

PI_NAMEs: ROBERTS, DAVID W (contact)

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: 3-Dimensional;Acceleration;Algorithms;animal data;Animals;Automation;Brain;Brain Neoplasms;brain tumor resection;Calibration;career;Clinical;Clinical Data;clinical research site;clinically relevant;Code;Collection;commercialization;Computer software;Data;data acquisition;design;Diagnosis;Entrepreneurship;Equity;Excision;Faculty;Family suidae;Funding;Future;Glioma;Image;image guided;Image-Guided Surgery;improved;in vivo;Incentives;innovation;insight;Intellectual Property;invention;Laboratories;Legal patent;Magnetic Resonance Imaging;Malignant neoplasm of brain;Marketing;member;Meta-Analysis;Modeling;mortality;Multi-site clinical study;Navigation System;neurosurgery;Operative Surgical Procedures;Patient-Focused Outcomes;Patients;Performance;Phase;Policies;pre-clinical;Procedures;Progress Reports;Progression-Free Survivals;prospective;reconstruction;Research;Resected;Risk;Scanning;Site;software systems;Software Validation;Speed;Surface;Surgeon;Surveys;System;Technology;Testing;United States National Institutes of Health;Update;Validation;verification and validation;Vision

PROJECT_TITLE: Intraoperative Stereovision for Surgical Guidance


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Orphan Drug;Ovarian Cancer;Precision Medicine;Rare Diseases;Women's Health Research

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative: The high mortality rate associated with ovarian cancer results from the failure of tumor-directed therapy to produce lasting treatment responses. Published work from our lab demonstrates that combining PARP-inhibitors with immune checkpoint blockade can achieve long-term survival in ovarian cancer models and may overcome treatment resistance in patients with recurrent disease. Here we will investigate the mechanisms responsible for the therapeutic synergy of this combination to enable the optimal integration of immune therapy with cytotoxic regimens for long-term benefit in women with ovarian cancer.

PI_NAMEs: ADAMS, SARAH FOSTER (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Acceleration;Address;Adenosine Diphosphate Ribose;Adoption;Antibodies;antibody inhibitor;Antibody Therapy;Area;Biological Markers;Blood specimen;blood treatment;BRCA1 gene;BRCA1 Mutation;BRCA2 Mutation;Cancer Biology;cancer cell;Cancer Model;cancer therapy;candidate validation;CD8-Positive T-Lymphocytes;Cell Cycle;Cell Death;Cells;Clinical;Clinical Data;clinical translation;Clinical Trials;Collaborations;combinatorial;Correlative Study;CTLA4 blockade;CTLA4 gene;cytotoxic;Cytotoxic agent;cytotoxicity;Data;Death Rate;Development;Disease;Disease Outcome;efficacy evaluation;Environment;Failure;Gene Expression;genetic signature;Goals;Immune;immune checkpoint;immune checkpoint blockade;Immunobiology;immunogenic;immunogenic cell death;Immunologic Memory;Immunologic Monitoring;immunoregulation;Immunotherapy;In Vitro;in vivo;inhibitor;Interferon Type II;Interferons;Knowledge;Leukocytes;Link;Lymphocyte;Macrophage;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Melanoma;Modeling;Mus;mutation carrier;novel;ovarian neoplasm;PARP inhibition;participant enrollment;Patient Selection;Patient-Focused Outcomes;Patients;Phase;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;pre-clinical;predicting response;predictive marker;Production;Publishing;recruit;Recurrence;Recurrent disease;Regimen;Resistance;response;response biomarker;Sampling Studies;Signal Transduction;Solid Neoplasm;synergism;T-Lymphocyte;Testing;Therapeutic;therapy resistant;Translations;treatment effect;Treatment Efficacy;Treatment outcome;treatment response;tumor;Tumor Immunity;tumor microenvironment;Woman;women's treatment;Work

PROJECT_TITLE: Mechanisms of Selective Therapeutic Synergy of PARP-inhibition and CTLA4 Blockade Engaged by Interferon-gamma in the Ovarian Tumor Microenvironment


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Lung;Lung Cancer;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PHR: Project Narrative: The proposed research will offer a chemokine-based patient stratification and chemokine as a target for therapies, establish immune-based strategies to reduce disparity, and evidence-based social interventions to potentiate anti-tumor immunity to reduce risk and improve survival of lung cancer (NSCLC) patients.

PI_NAMEs: RIVERS, BRIAN M.;SINGH, RAJESH ;SINGH, SHAILESH  (contact)

PROGRAM_OFFICER_NAME: CARRICK, DANIELLE M

PROJECT_TERMS: Address;Affect;African American population;American;Apoptosis;aspirate;Behavioral Sciences;beta-Chemokines;Bioinformatics;Biologic Characteristic;Biological;Biological Factors;biomarker identification;Biometry;Biopsy;Blood;Bronchoscopy;Cancer Biology;Cancer cell line;cancer health disparity;cancer immunobiology;Cancer Patient;cancer therapy;Caring;CCL20 gene;Cell Line;Cell Proliferation;Cells;Censuses;Characteristics;chemokine;chemokine receptor;Chronic stress;Cigarette;Classification;Clinical Trials;cohort;Computer software;Consent;Consumption;Data;Data Analyses;design;detection method;Diagnosis;Disease;Disease Outcome;Disparity;disparity reduction;effective therapy;Enrollment;Enzyme-Linked Immunosorbent Assay;ethnic disparity;Ethnic Origin;Ethnic Population;European;evidence base;Evidence based intervention;Gender;Gene Expression Profiling;Goals;Hospitals;Hydrocortisone;Immune;immune cell infiltrate;Immune system;Immunity;Immunologics;Immunophenotyping;Immunotherapy;improved;Incidence;Individual;Interdisciplinary Study;Investigational Drugs;Knowledge;Ligands;Link;Lung;lung cancer cell;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Methods;Molecular;mortality;multidisciplinary;National Institute on Minority Health and Health Disparities;Neighborhoods;Nodal;Non-Small-Cell Lung Carcinoma;Oncology;Outcome;Pathology;Pathway interactions;patient stratification;patient subsets;Patients;peripheral blood;Phenotype;Physiology;Prognosis;Prognostic Marker;Proteins;Public Health;Puncture biopsy;Race;racial difference;racial disparity;racial population;recruit;Research;Risk;Risk Factors;Risk Reduction;Role;Saliva;Sampling;Serum;Shapes;Smoking;social;Social Characteristics;social factors;social interventions;social stress;Socioeconomic Status;stemness;Stress;success;Supporting Cell;targeted treatment;The Cancer Genome Atlas;therapeutic biomarker;therapeutic target;therapy outcome;Tissues;trait;transcriptome;treatment response;tumor;Tumor Immunity;Tumor stage;Tumor Tissue;Visit;Work

PROJECT_TITLE: The interplay of social and molecular determinants in lung cancer disparity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-Z(55)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Human Genome;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PUBLIC HEALTH RELEVANCE Addiction-related health issues are estimated to cause 590,000 deaths and 40 million illnesses or injuries annually in the U.S. While the progression to addiction is a complex process and depends on many factors, including environment, the propensity to become addicted to drugs of abuse is strongly influenced by genetics. In this project, we will use precise genome editing in mice to identify signaling pathways that mediate addiction behaviors to produce novel preclinical mouse models that could be used to help identify novel therapeutic targets.

PI_NAMEs: KUMAR, VIVEK  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Actins;Acute;addiction;Affect;Alcohols;Alleles;Amino Acid Substitution;Behavior;Behavioral;behavioral phenotyping;Binding;Biochemical;Biochemistry;Biological Assay;Biophysics;Brain region;Cell Surface Receptors;Cessation of life;chronic alcohol ingestion;Cloning;Cocaine;cocaine self-administration;cocaine sensitization;Communities;Complement;Complex;conditioned place preference;Consultations;cost;CRISPR/Cas technology;Critical Pathways;Data;design;Dideoxy Chain Termination DNA Sequencing;Discipline;Dissection;Dissociation;drug of abuse;Eating;Economics;effective therapy;Environment;Event;Family;FMR1 gene;Food;Fragile X Syndrome;Future;Generations;Genes;Genetic;genetic approach;Genetic Models;genome editing;Genome engineering;genome sequencing;Goals;Health;in vivo;Injury;insight;Intravenous;Knock-out;Knowledge;Learning;Mass Spectrum Analysis;Measures;Mediating;Mediator;mesolimbic system;Modeling;Molecular;Monomeric GTP-Binding Proteins;mouse genetics;mouse model;multidisciplinary;multidrug abuse;Mus;mutant;Mutant Strains Mice;Mutation;neurobiological mechanism;new therapeutic target;Nicotine;novel;Pathway interactions;Phase;Phenotype;Play;polymerization;Polymers;postnatal;pre-clinical;precise genome editing;preference;Process;protein protein interaction;Proteins;Proteomics;public health relevance;Publishing;Quantitative Trait Loci;receptor;recruit;repaired;Research;Research Personnel;response;Rewards;Role;Series;Signal Pathway;Signal Transduction;Signaling Protein;Site;social;Structure;Sucrose;targeted treatment;Testing;The Jackson Laboratory;Therapeutic Intervention;therapeutically effective;tool;Translations;Variant;whole genome;Work

PROJECT_TITLE: Dissection of Addiction Relevant Signal Integration by Cyfip2 through Precise Genome Engineering


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Sugar-sweetened beverages (SSBs) contribute an alarming ~7% of calories in the US diet among adults, making them the single largest source of added sugar. However, whether artificially sweetened beverages are a healthful alternative for reducing SSB intake among habitual SSB consumers is unknown. Therefore, we propose a 4-arm randomized diet intervention trial to test the effects of substituting SSBs with calorie-free alternatives on body weight and health, among habitual SSB consumers with overweight/obesity.

PI_NAMEs: TOBIAS, DEIRDRE KAY (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Address;Adherence;Adult;Age;arm;Artificial Sweeteners;Aspartame;Awareness;Behavior;Beverages;Blood;Blood Pressure;Body mass index;Body Weight;Body Weight decreased;Body Weights and Measures;Calories;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cellular Phone;Clinic Visits;Clinical;Clinical Trials;Clinical Trials Design;Collection;Compensation;Consumption;Control Groups;Data Collection;design;Desire for food;diabetes risk;Diet;dietary;dietary guidelines;Dietary Intervention;dieting;digital;disorder risk;Effectiveness;effectiveness evaluation;Eligibility Determination;energy balance;Enrollment;Ensure;Epidemiology;epidemiology study;Etiology;Feasibility Studies;fecal microbiome;Feces;feeding;follow-up;Frequencies;Future;Health;Heterogeneity;High Density Lipoproteins;Home;improved;Inflammation;Infrastructure;innovation;insulin sensitivity;Intake;Intention;Interleukin-6;Intervention;intervention delivery;Intervention Trial;Knowledge;Label;Life Style;lifestyle factors;Link;Lipids;Marketing;Measures;Metabolism;Methods;Modeling;Modernization;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutritional;Obesity;obesity prevention;obesity risk;Observational Study;Overweight;Participant;Pattern;Persons;Physical activity;Pilot Projects;Population Heterogeneity;Preventive Medicine;primary outcome;Public Health;public health intervention;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research Personnel;Residual state;Sampling;secondary analysis;Source;sugar;Sugar Substitute;sweetened beverage;Taste preferences;Taxation;Testing;tool;treatment group;trial design;United States National Institutes of Health;Urine;Visit;waist circumference;Water;web app;Weight Gain;wireless fidelity

PROJECT_TITLE: Health effects of substituting sugar-sweetened beverages with non-caloric beverages in adults with overweight and obesity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-E(02)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Bioengineering;HIV/AIDS;Nanotechnology

ORG_CITY: BERKELEY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: RELEVANCE (See instructions): Unconstrained evolution of HIV-1 proteins leads to rapid drug resistance, thus new targets are being sought among host-virus protein complexes in order to circumvent drug resistance. HIV-1 release is a vital step in the viral life cycle that is not targeted by any current drugs, owing in part to a lack of information on how to separate interactions hijacked by HIV from those necessary for normal physiology. This project will reveal the mechanistic basis for HIV assembly, budding, and release in unprecedented

PI_NAMEs: HURLEY, JAMES H (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: animation;ATP phosphohydrolase;Award;Biochemical;Biophysics;Capsid;Cebidae;Cell membrane;Cell Physiology;Cells;Collaborations;Communication;Communities;Complex;Coupled;Cryo-electron tomography;Cryoelectron Microscopy;Dominant-Negative Mutation;Drug resistance;Event;Evolution;gag Gene Products;Genome;Glycoproteins;Guide RNA;HIV;HIV-1;Homologous Gene;Human;Image;In Situ;In Vitro;Instruction;Ions;laser tweezer;Life Cycle Stages;Mediating;Membrane;Modeling;movie;Nanotubes;Neck;Normal Cell;optic tweezer;particle;Pathway interactions;Pharmaceutical Preparations;Physiology;Positioning Attribute;Process;protein complex;Proteins;reconstitution;recruit;Research;Resolution;Retroviridae;RNA;Sampling;simulation;Structure;System;Tomogram;Viral;Viral Proteins;Virus;Virus Replication;Work

PROJECT_TITLE: Biochemical, Biophysical, and Structural Mechanisms of HIV-1 Budding and Release


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Lung;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: In light of the “opioid crisis,” providers face a clinical conundrum of balancing opioid addiction risk with increasing concern of the undertreatment of patients in legitimate pain. The current proposal seeks to investigate a new class of fentanyl derivatives designed to maintain clinical efficacy with decreased potency to elicit unwanted effects (i.e., addiction, respiratory depression.) The findings of this proposal will improve public health through the development of safer analgesic options.

PI_NAMEs: EDWARDS, SHELLEY R (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: abuse liability;addiction;Agonist;Analgesics;antinociception;Area;Attention;behavior measurement;behavioral pharmacology;Brain;career;Characteristics;Chemicals;Clinical;clinical efficacy;Clinical Medicine;conditioned place preference;Coupled;Data;Dependence;design;Development;Dose;Dose Limiting;drug discovery;efficacious treatment;efficacy testing;Ensure;Environment;Exposure to;Face;Fellowship;Fentanyl;fentanyl analog;Goals;graduate school;Health Sciences;improved;Inflammation;Inflammatory;inflammatory pain;injured;Injury;Intravenous;Investigation;Ligands;Light;Literature;male;Measurable;Measures;Medical center;Methods;Mississippi;Modality;Modeling;mu opioid receptors;Mus;Neuropathy;Neurosciences;novel;Opiate Addiction;Opioid agonist;opioid epidemic;Oxycodone;Pain;Pain management;Patients;Pharmaceutical Preparations;Physicians;Physiological;Preparation;programs;Property;protonation;Provider;Public Health;Rattus;receptor;Receptor Activation;Reinforcement Schedule;reinforcer;Reporting;Research;respiratory;response;Rewards;Risk;Rodent;Route;Safety;Scientist;Self Administration;sex;side effect;Standardization;Structure;Testing;Therapeutic;therapeutic opioid;Tissues;Training;Universities;Ventilatory Depression;Whole Body Plethysmography;women subjects;Work

PROJECT_TITLE: Behavioral Pharmacology of Injury Restricted Fentanyl Analogues.


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Immunization;Immunotherapy;Lung;Lung Cancer;Precision Medicine;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative We need better ways to select patient most likely to respond to new antibody treatments with multiple ways to kill cancer cells. We propose to produce a highly useful imaging toolkit to understand the different ways that the antibody kills cancer cells in animal models of triple negative breast cancer and non-small cell lung cancer.

PI_NAMEs: MARQUEZ-NOSTRA, BERNADETTE  (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Acceleration;Affinity;Animal Model;Antibodies;Antibody Therapy;Antigens;Binding;Biological;Bispecific Antibodies;Breast Cancer cell line;cancer cell;Cancer cell line;Cell Line;Cell surface;Clinical Trials;companion diagnostics;Complement;Correlative Study;Cytoplasm;Data;design;Diagnostic Procedure;DNA Sequence Alteration;Drug Delivery Systems;Drug Exposure;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Epithelium;Erlotinib;Future;Gene Amplification;Goals;Growth Factor Receptors;Half-Life;Heterogeneity;Image;imaging approach;imaging biomarker;Imaging Techniques;Immunohistochemistry;In Vitro;in vivo;in vivo Model;Individual;innovation;Label;Ligands;Measures;Mesenchymal;MET gene;Methods;Monitor;mortality;mutant;Mutation;mutational status;non-invasive imaging;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;overexpression;Patient Selection;Patients;Positron-Emission Tomography;Pre-Clinical Model;preclinical study;predicting response;Predictive Value;Radioactive;radioligand;radiotracer;receptor;receptor expression;Receptor Inhibition;Resistance;Resistance development;resistance mechanism;response;response biomarker;Role;Specificity;standard of care;targeted treatment;Techniques;Testing;Therapeutic;Tissue Sample;tool;Tracer;Translating;translational study;treatment response;triple-negative invasive breast carcinoma;tumor;tumor growth;uptake;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Imaging the multifaceted response to a bispecific antibody therapy

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Lung;Prevention;Rare Diseases;Social Determinants of Health;Tuberculosis

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Latent tuberculosis (TB) is referred to as the “seedbed” of TB disease, and TB elimination goals cannot be reached without addressing latent TB. Treatment of latent TB prevents progression to active TB, but completion rates are low. To address this problem, this study evaluates novel and scalable interventions that combine smartphone enabled adherence support through video observations of treatment (with case- management and electronic reminders), with and without financial incentives to promote completion of treatment for latent TB in in Baltimore, MD.

PI_NAMEs: SHAH, MAUNANK  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Address;Adherence;Adult;Affect;arm;Baltimore;Behavior;Caring;Case Management;Cellular Phone;Cities;Clinic;Collaborations;Communities;comorbidity;compliance behavior;cost;cost effectiveness;cost estimate;cost per quality-adjusted life year;Coupled;COVID-19 impact;Data;Diabetes Mellitus;Diagnosis;Directly Observed Therapy;Disease;Dose;Drug Prescriptions;economic behavior;economic evaluation;economic incentive;effective intervention;effectiveness evaluation;Effectiveness of Interventions;Electronics;Eligibility Determination;experience;Feedback;Financial Hardship;financial incentive;Goals;Health;health care availability;health literacy;Health system;high risk population;HIV;Homelessness;Housing;Immigrant;improved;Incentives;incremental cost;incremental cost-effectiveness;Individual;Infection;Ingestion;Intervention;Language;Latin America;Latino Population;Length;Low Income Population;Maryland;Measurement;Medical;Modeling;Monitor;Mycobacterium tuberculosis;Not Hispanic or Latino;novel;Nursing Assessment;Outcome Measure;Parameter Estimation;Participant;Patients;Persons;Population;Poverty;prevent;Preventive therapy;primary outcome;programs;progression risk;Public Health;Randomized;randomized trial;randomized, clinical trials;real time monitoring;Recommendation;Regimen;Remunerations;Reporting;Research;Rifamycins;scale up;Self Administration;Socioeconomic Factors;sound;standard care;success;System;Testing;therapy design;Time;transmission process;treatment as usual;Treatment Protocols;trial comparing;Tuberculosis;tuberculosis treatment;Uncertainty;United States;Wages;Work

PROJECT_TITLE: Video DOT and Economic Incentives to promote adherence to LTBI therapy

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Pediatric;Prevention;Rare Diseases;Vaccine Related

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Despite widespread vaccination, measles remains a leading cause of child mortality globally; in addition, it has been re-emerging in previously measles-free regions (e.g., the recent case increases in the US and re- establishment of endemic transmission in the UK and Venezuela in South America). By studying mechanisms governing the spread of measles in the modern, mass vaccination era, the proposed work will improve understanding of the persistence of measles transmission and aid development of improved interventions to eliminate measles worldwide.

PI_NAMEs: YANG, WAN  (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Affect;Age;Age Distribution;Americas;Area;Bayesian Analysis;Bayesian Modeling;Birth Rate;Case Study;Cause of Death;Child;Child Mortality;China;Chinese;chronic infection;Cities;combat;Communicable Diseases;Complex;Data;Data Set;Demographic Factors;demographics;Development;Disease;Disease Outbreaks;Emerging Communicable Diseases;emerging pathogen;Epidemic;Evidence based intervention;Frequencies;Future;Hospitals;improved;Industrialization;Infant;Infection;infectious disease model;International;Intervention;Mass Vaccinations;Maternally-Acquired Immunity;mathematical model;Measles;Measures;Methods;Migrant;Migrant Workers;migration;Modeling;Modernization;National Institute of Allergy and Infectious Disease;network models;Newborn Infant;novel;older adult;Outcome;Parents;Pattern;Policies;Poliomyelitis;Population;Population Dynamics;Predisposition;Public Health;Research;Rubella;rural area;Smallpox;South America;Statistical Methods;Structure;surveillance data;synergism;System;Testing;theories;transmission process;Travel;Vaccinated;Vaccination;Vaccines;Venezuela;Work;young adult

PROJECT_TITLE: Disease Persistence and Population Dynamics: Modeling Measles under Mass Vaccination

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Lung cancer is the leading cause of cancer mortality in the nation, and the burden of the illness is disproportionally experienced by individuals residing in rural areas and experiencing economic challenges. Recent advances in early detection and treatment of lung cancer foretell significant reductions in lung cancer mortality, engendering a need for research efforts to inform lung cancer survivorship care guidelines. This research outlines a randomized clinical trial of a precision lung cancer survivorship care intervention aimed at improving quality of life among rural lung cancer survivors within socioeconomically distressed areas in the US.

PI_NAMEs: STAPLETON, JEROD L;STUDTS, JAMIE L (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Advocate;Appalachian Region;Area;behavior change;Bibliotherapy;burden of illness;Cancer Burden;cancer care;Cancer Care Facilities;Cancer Etiology;Cancer Survivor;Cancer Survivorship;cancer survivorship care;care delivery;Caregivers;Caring;Cessation of life;Clinical;Collaborations;Communities;community advisory board;community collaboration;comparative efficacy;cost effective;cost effectiveness;cost-effectiveness evaluation;Data;Development;Distress;Early Diagnosis;Early treatment;Economics;Educational Status;experience;feasibility trial;Fostering;Foundations;Goals;Guidelines;Health behavior;Health behavior and outcomes;Health behavior change;health care availability;Health care facility;Illness impact;implementation design;improved;improved outcome;Incidence;Individual;informal caregiver;Infrastructure;innovation;Intervention;intervention program;Kentucky;lung cancer prevention;Malignant neoplasm of lung;Measures;Methods;Modeling;mortality;motivational enhancement therapy;novel;Oncology;optimism;Outcome;patient engagement;Patient-Centered Care;pilot trial;Play;Population;Poverty;preference;Prevention;programs;psychologic;psychological distress;psychosocial wellbeing;Quality of Care;Quality of life;quality of life for cancer survivors;randomized, clinical trials;Randomized, Controlled Trials;recruit;Research;Role;Rural;rural America;rural area;rural cancer care;Rural Community;screening;shared decision making;social;social stigma;socioeconomic disadvantage;socioeconomics;Survivors;survivorship;Symptom Burden;symptom management;Symptoms;Thoracic Oncology;Tobacco;treatment as usual;Treatment Efficacy;Treatment Side Effects;trial comparing;underserved community;United States National Institutes of Health;Wages

PROJECT_TITLE: Precision Lung Cancer Survivorship Care Intervention: A Randomized Controlled Trial Serving Rural Survivors and Communities


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: ALLEN INSTITUTE

ORG_STATE: WA

PHR: We propose to create VOrtex, a virtual observatory for a cubic millimeter of cortex. The observatory will enable researchers to study neuronal and glial cell biology, cell types, and neural circuit structure and dynamics. New and fundamental knowledge about the cortex will inform basic research as well as research on brain diseases.

PI_NAMEs: COLLMAN, FORREST CHRISTIE;MACARICO DA COSTA, NUNO ;REID, R CLAY (contact);SEUNG, HYUNJUNE SEBASTIAN

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TERMS: Acceleration;Address;Area;Astronomy;automated segmentation;Basic Science;Brain;Brain Diseases;Calcium;cell cortex;cell type;Cells;Cellular biology;Classification;clinically relevant;Communities;Computer Analysis;Computer software;cortex mapping;cost;Data;data access;Data Set;data sharing;Dependence;design;Doctor of Philosophy;Drosophila genus;Education and Outreach;Educational process of instructing;Educational workshop;Event;experimental study;extrastriate visual cortex;fly;Frequencies;Funding;Human;Image;imaging Segmentation;instrument;Internet;Knowledge;learning materials;Link;Location;Manuals;Mechanics;millimeter;Morphology;Mus;nanoscale;network models;neural circuit;Neurobiology;Neuroglia;Neurons;Neurosciences;novel strategies;Organelles;outreach;Persons;petabyte;Physiology;Procedures;programs;Quality Control;reconstruction;recruit;Research;Research Personnel;Resource Sharing;Resources;response;Schedule;Scientist;simulation;Site;Slice;social media;Specialist;Stimulus;Structure;success;Synapses;Techniques;Testing;theories;Time;Update;virtual;visual coding;Visual Cortex;visual stimulus;wasting

PROJECT_TITLE: Virtual observatory of the cortex: organelles, cells, circuits, and dynamics


ADMINISTERING_IC: NR

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Clinical Research;Disability Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation

ORG_CITY: Newark

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Every year, 400,000 million skilled nursing facility (SNF) patients with Alzheimer’s disease and related dementias (ADRD) transfer from SNFs to home and other destinations. Following these transitions, (1) patients with ADRD experience high rates of preventable dementia symptoms and re-hospitalization and (2) caregivers of people with ADRD experience high levels of strain and psychological harm. To improve these outcomes, we propose a cluster randomized trial of Connect-Home ADRD, a transitional care intervention for persons with ADRD and their caregivers during care transitions from SNFs to home, assisted living, and long term care.

PI_NAMEs: TULSKY, DAVID SCOTT (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Acquired disability;Address;Affect;associated symptom;Brain;Caring;Characteristics;Chronic;Clinical;Clinical Assessment Tool;clinical care;clinical diagnostics;clinical practice;cognitive recovery;cohort;comorbidity;Complex;cost;Data Set;Development;Diagnostic;disability;Discipline of Nursing;Disparate;Educational workshop;Emergency Care;Emergency treatment;emotional symptom;empowerment;Equipment;Etiology;experience;Face;Goals;Guidelines;Health;Health Personnel;Healthcare;Heterogeneity;improved;improved outcome;Individual;Injury;innovation;instrument;Intervention;Knowledge;Life;Limb structure;Literature;Long term disability;Long-Term Care;Malignant Neoplasms;Measures;Medical;Medical emergency;Methods;Modeling;Morbidity - disease rate;National Institute of Nursing Research;Neurobehavioral Manifestations;neuromusculoskeletal;NIH Program Announcements;novel;Nursing Research;Oncology;Outcome;Outcome Measure;Outcomes Research;Participant;Patient Outcomes Assessments;Patients;Pattern;personalized medicine;personalized strategies;Persons;Pharmaceutical Preparations;physical symptom;Population;Process;Provider;psychosocial;Quality of life;Recommendation;rehabilitation research;rehabilitation science;Rehabilitation therapy;Relative Risks;Reproducibility;Research;Research Personnel;Sampling;Science;Site;Spinal Cord;Spinal cord injury;Stroke;Symptom Burden;symptom cluster;symptom management;Symptoms;Techniques;Time;tool;Translating;Trauma;Traumatic Brain Injury;traumatic event;Traumatic injury;United States;Vertebral column;Work

PROJECT_TITLE: Measuring Symptom Clusters in People with Sudden-Onset Disabilities

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE We have successfully examined the needle photoacoustic probe in detecting aggressive prostate cancers during the first years of this project. During the extension period of this project, we will further develop the needle photoacoustic probe technologies and examine the technologies using the established protocols.

PI_NAMEs: XU, GUAN  (contact)

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: 3-Dimensional;American;Animal Model;Anxiety;Applications Grants;Architecture;Biopsy;blood-based biomarker;cancer diagnosis;Cancer Etiology;Cancer Patient;Cancerous;Cessation of life;Clinical;clinical care;clinical implementation;clinical practice;Clinical Trials;clinically significant;Collagen;Core Biopsy;cost;Data;design;Diagnosis;Diagnostic;Diagnostic Neoplasm Staging;Diagnostic Procedure;diagnostic strategy;Dimensions;Early Diagnosis;Effectiveness;Excision;experimental study;Future;Gleason Grade for Prostate Cancer;Hemoglobin;Heterogeneity;Histologic;Histology;Human;human subject;improved;in vivo;Individual;Knowledge;Lipids;Location;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Maps;Measurement;men;Molecular;Molecular Bank;Needle biopsy procedure;Needles;non-alcoholic fatty liver disease;Optics;Pain;parent grant;Pathology;Patients;Penetration;Performance;Pilot Projects;Probability;Procedures;Prognostic Factor;Prostate;prostate biopsy;Prostatectomy;Protocols documentation;prototype;Regional Cancer;Research;Risk;Sampling;Screening for Prostate Cancer;Sensitivity and Specificity;Signal Transduction;Stains;Structure;Study Subject;System;Technology;Testing;Time;Tissue Sample;Tissues;Transrectal Ultrasound;Tube;tumor;Visualization

PROJECT_TITLE: Real time fine needle assessment of architectural heterogeneity in prostate cancer


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Solid tumors present a significant public health issue despite intense research and advances in patient care. Based on recent research, we now realize that tumors must avoid recognition by the immune system to progress but the underlying mechanisms are not well understood. Our work will delineate a key immune evasion pathway in solid tumors and establish the value of targeting this pathway for immunotherapy.

PI_NAMEs: HALDAR, MALAY  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: adaptive immune response;Affect;angiogenesis;anti-tumor immune response;Antigen Presentation;Antigen-Presenting Cells;Antigens;Biology;Cell Death;Cell Differentiation process;Cell Separation;Cells;Cellular biology;Clinical;cytokine;Data;Dendritic Cells;Detection;Enzymes;Flow Cytometry;Functional disorder;Generations;Genetic;Genetically Engineered Mouse;Goals;Hematopoietic;Human;immune checkpoint blockade;Immune Evasion;Immune response;Immune system;Immune Targeting;immunoregulation;Immunosuppression;immunosuppressive macrophages;Immunotherapy;in vivo;Infiltration;inhibitor;innovation;Interleukin-13;IRF4 gene;Laboratories;Macrophage;Malignant Neoplasms;Mediating;Modeling;Molecular;monocyte;mouse model;neoplasm immunotherapy;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;Ovalbumin;Parents;Pathway interactions;Patient Care;pharmacologic;Positioning Attribute;Pre-Clinical Model;prevent;Production;Public Health;Radiation;Radiation therapy;recruit;Regulation;Reporting;Research;Resources;Retinoids;Role;Sarcoma;Signal Transduction;small molecule inhibitor;Solid Neoplasm;Source;success;T cell response;T-Lymphocyte;Testing;Therapeutic;Therapeutic Uses;Tissues;tool;transcription factor;Translations;Tretinoin;tumor;Tumor Antigens;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Promotion;Tumor-associated macrophages;Tumor-Derived;Tumor-infiltrating immune cells;Work

PROJECT_TITLE: Regulation of antigen presenting cells in the tumor microenvironment by retinoic acid


ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE (from parental grant) A new highly drug resistant form of aggressive prostate cancer characterized by no neuroendocrine features and low androgen receptor (AR) levels is on the rise and very little is known about the cellular processes that govern its growth. We have discovered that the steps of protein synthesis are absolutely critical for AR low prostate cancer cell proliferation in vitro and in vivo, which represents a potential therapeutic vulnerability. Our goal is to definitively investigate the fundamental link between AR and protein synthesis and determine the therapeutic implications of targeting this interface.

PI_NAMEs: HSIEH, ANDREW CALEB (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: abiraterone;advanced prostate cancer;Androgen Antagonists;androgen biosynthesis;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;Binding Proteins;Cancer Etiology;Cancer Patient;Cell Line;Cell Physiology;Cell Proliferation;Cessation of life;cohort;Collection;Communication;Data;Development;Disease;disease model;DNA;Drug resistance;enzalutamide;Exhibits;Experimental Genetics;Gene Expression Process;Gene Expression Regulation;Generations;Genes;Genetic Models;Goals;Grant;Growth;hormonal signals;Human;human model;human tissue;Hyperactivity;Iatrogenesis;In Vitro;in vivo;Individual;inhibitor;International;intratumoral androgen;Laboratories;Link;Maintenance;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mediating;men;Messenger RNA;Methods;Modeling;Molecular;mouse model;mRNA Translation;Mus;Neurosecretory Systems;new technology;Oncogenes;Oncogenic;Organoids;Pathogenesis;patient derived xenograft model;Patients;Peptide Initiation Factors;Phenotype;pre-clinical;preclinical study;Process;prognostic;programs;Proliferating;prostate cancer cell;Protein Biosynthesis;Proteins;receptor;Receptor Signaling;Regulatory Element;response;ribosome profiling;RNA;Role;Sampling;Seminal;Series;Signal Transduction;Specificity;Study models;Testing;Therapeutic;therapy development;Tissues;transcriptome;Translation Initiation;Translational Regulation;Translations;Treatment Efficacy;treatment response;tumor growth;United States;Work

PROJECT_TITLE: Hormone signaling and translation control in advanced prostate cancer