NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cardiovascular;Childhood Obesity;Clinical Research;Disability Research;Heart Disease;Hematology;Lung;Nutrition;Obesity;Pediatric;Physical Activity;Prevention

ORG_DEPT: PEDIATRICS

PHR: NARRATIVE Exercise intolerance and shortness of breath in children and young adults are common after blood clots in legs and lungs and an important cause of disability in otherwise healthy kids. The cause is currently unknown. Our research will investigate why these symptoms occur and help design future trials of exercise training.

PI_NAMEs: ZIA, AYESHA  (contact)

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: 3-Dimensional;Accelerometer;Activities of Daily Living;Adherence;Adult;adverse outcome;Aerobic Exercise;Affect;Affective;Anticoagulation;Bioenergetics;Blood coagulation;Blood Vessels;Body mass index;Body Weight decreased;Breathing;Cardiac;cardiac magnetic resonance imaging;Cardiology;Cardiovascular system;Child;Childhood;Chronic;Clinical;Clinical Treatment;clinically relevant;clinically significant;cohort;common symptom;Coupling;Data;deconditioning;Deep Vein Thrombosis;design;Diagnosis;disability;Disease;Distress;Dyspnea;Echocardiography;emotional distress;Exercise;exercise capacity;exercise intolerance;exercise training;Exertion;experience;Fatigue;Feeling;fitness;Functional disorder;Future;Goals;Hematology;hemodynamics;Hospitalized Child;imaging science;Impairment;improved;in vivo;Incentives;Incidence;Intervention;K-Series Research Career Programs;Leg;Limb structure;Lower Extremity;Lung;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measurement;Measures;Metabolic;Muscle;National Heart, Lung, and Blood Institute;novel;Obesity;Obstruction;Outcome;Patients;pediatric patients;Perfusion;Peripheral;Phosphocreatine;Physical activity;Physiological;Physiology;Play;Postphlebitic Syndrome;prevent;Prospective, cohort study;Pulmonary artery structure;Pulmonary Circulation;Pulmonary Embolism;Quality of life;Recovery;Recurrence;Research;Resolution;Respiratory Mechanics;Rest;Right Ventricular Dysfunction;Right ventricular structure;Risk Factors;Secondary to;sedentary;Sensory;Shortness of Breath;Site;Skeletal Muscle;skeletal muscle metabolism;Symptoms;Syndrome;Testing;Thinking;thromboinflammation;Thrombosis;Thrombus;Translational Research;Venous;venous thromboembolism;Venous Thrombosis;ventilation;Ventricular;Work;young adult

PROJECT_TITLE: Functional Characterization of Children with Chronic Venous Thromboembolic Disease

STUDY_SECTION: HT

STUDY_SECTION_NAME: Hemostasis and Thrombosis Study Section.  Committee was terminated on 11/30/2020. [HT]


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: PROVIDENCE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PI_NAMEs: HOCHBERG, LEIGH R (contact)

PROJECT_TITLE: BrainGate: Robust Neural Decoding for Veterans with ALS

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Relevance Polycystic Kidney Disease (PKD) is a common cause of end stage renal failure worldwide. Although the first therapeutic agent to treat the autosomal dominant form of the disease was recently approved by regulatory agencies, this treatment has significant side effects and slows but does not prevent disease progression. We must continue to refine our understanding of the PKD signaling nexus in order to identify additional therapeutic targets. A new generation of prospective therapeutics will have the best chance of clinical success if they are informed by robust basic discovery research and rigorous translation science. The mission of the Maryland PKD Research and Translation Core Center is to provide state of the art resources and expertise to broad community of investigators with the goal of advancing innovative translational science in the field of Polycystic Kidney Disease. Through expanded interdisciplinary collaborations, we hope to catalyze the translation of biomedical discoveries that will prevent progression of polycystic kidney disease and its consequences.

PI_NAMEs: WATNICK, TERRY J (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Address;Antibodies;Area;autosome;Baltimore;base;Basic Science;biobank;Biomedical Research;Cell Culture Techniques;cellular engineering;Clinical;clinical investigation;Collaborations;Communities;Country;Discipline;Disease;Disease Progression;End stage renal failure;experience;Future;Generations;Goals;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;Knowledge;Leadership;Maryland;medical schools;Mission;mouse model;National Institute of Diabetes and Digestive and Kidney Diseases;Polycystic Kidney Diseases;prevent;prospective;Reagent;Research;Research Personnel;Resources;Science;side effect;Signal Transduction;Stretching;student participation;success;Therapeutic;Therapeutic Agents;therapeutic target;Translational Research;Translations;Universities;vector;Vision

PROJECT_TITLE: Maryland Polycystic Kidney Disease Research and Translation Core Center (MPKD-RTCC)


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

PROJECT_TERMS: 3-Dimensional;Acceleration;Advisory Committees;Area;Baltimore;Biomedical Research;Budgets;career;Communication;Communities;Complex;cost;Development;Ensure;experience;Generations;Goals;Human Resources;Infrastructure;innovation;Institution;Kidney;Leadership;Maryland;medical schools;Mission;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;operation;Personnel Management;Physiology;Polycystic Kidney Diseases;Process;programs;Reagent;Recommendation;Recovery;Research;Research Personnel;Research Project Grants;Resource Allocation;Resources;Science;Site;Structure;summer student;Translations;Universities

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Immunization;Immunotherapy;Kidney Disease;Nanotechnology;Pediatric;Polycystic Kidney Disease

PI_NAMEs: QIAN, FENG  (contact)

PROJECT_TERMS: 3-Dimensional;Affinity;Animal Model;Animals;anti-PD1 antibodies;Antibodies;Antibody Affinity;Antigens;Area;Basic Science;Binding;Biochemistry;Biotechnology;Cell Culture System;Cell surface;Cells;Clinical Trials;Cloning;Communities;Complementary DNA;Complex;Critical Pathways;Development;Educational process of instructing;Epitopes;experience;expression vector;Gene Expression;Genes;Goals;Immunization;Immunize;Immunoprecipitation;in vivo;innovation;Length;Libraries;Lipids;Mammalian Cell;Maryland;Membrane Proteins;Monoclonal Antibodies;Mus;mutant;Mutate;nanobodies;nanodisk;next generation;novel;novel strategies;Pathway interactions;Phage Display;PKD2 protein;polycystic kidney disease 1 protein;Polycystic Kidney Diseases;Positioning Attribute;Principal Investigator;programmed cell death protein 1;Property;Proprotein Convertase 1;Proprotein Convertase 2;protein complex;Protein Fragment;Proteins;Protocols documentation;Reagent;repository;Research;Research Personnel;restriction enzyme;Role;Science;Silent Mutation;Site;Specificity;Surface;Technical Expertise;tool;Transfection;Translations;Validation;vector;Western Blotting;Work

PROJECT_TITLE: Antibody Validation Vector Core


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease

PI_NAMEs: OUTEDA GARCIA, PATRICIA  (contact)

PROJECT_TERMS: Acceleration;Alleles;biobank;Biological;Blood;Breeding;Collection;Communities;Complex;congenic;Consultations;Cre lox recombination system;Custom;Disease;disease model;Disease Progression;embryo cryopreservation;Enterobacteria phage P1 Cre recombinase;experience;Familiarity;Gene Silencing;Gene Targeting;Genetic Engineering;Genotype;Goals;Grant;Health;Human;human disease;Image;in vivo;Individual;innovation;Institution;investigator training;LoxP-flanked allele;Maryland;Molecular;Monitor;mouse model;Mus;novel;pathogen;Pathogenesis;Polycystic Kidney Diseases;Preclinical Testing;preclinical trial;prevent;Proteins;Protocols documentation;Reagent;Renal function;Reporting;repository;Research;Research Personnel;Resources;Sampling;Services;Signal Pathway;sperm cell;Standardization;targeted agent;Testing;Therapeutic Agents;therapeutic target;Time;Tissues;tool;Transgenic Organisms;Translations;United States National Institutes of Health;Urine

PROJECT_TITLE: Mouse Model and Biobank Core (MMBC)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease

PI_NAMEs: WOODWARD, OWEN M (contact)

PROJECT_TERMS: 3-Dimensional;Academia;Acceleration;Address;Affect;Alleles;Antibodies;Autosomal Dominant Polycystic Kidney;Biological Assay;Cell Culture Techniques;Cell Line;Cell model;Cells;Cellular Assay;cellular engineering;Clinical;Clinical Data;Collaborations;Communities;Consultations;Coupled;Custom;Cyst;Cyst Fluid;Data;design;Duct (organ) structure;Ductal Epithelial Cell;Engineering;Ensure;Enterobacteria phage P1 Cre recombinase;Epithelial Cells;Experimental Designs;frontier;Future;Gene Expression;Gene Expression Profiling;Gold;Government;high standard;high throughput screening;Human;In Vitro;in vitro Model;Individual;inducible Cre;Industry;innovation;interest;Investigation;Kidney;kidney epithelial cell;knock-down;Knock-out;Knockout Mice;LoxP-flanked allele;Maryland;Modeling;Mus;mutant;Mutation;new technology;organizational structure;Organoids;Pathway interactions;Patients;Phenotype;Polycystic Kidney Diseases;Positioning Attribute;Preparation;Primary Cell Cultures;Procedures;Proliferating;Proprotein Convertase 1;Protocols documentation;Quality Control;renal epithelium;Reproducibility;Research;Research Personnel;Resources;screening;Services;single nucleus RNA-sequencing;Site;Specimen;Stretching;System;Tetracyclines;Therapeutic;therapeutic evaluation;Tissues;Translations;treatment response;Validation;validation studies;vector

PROJECT_TITLE: Cell Culture and Engineering Core (CCEC)


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease

PI_NAMEs: SELIGER, STEPHEN L. (contact)

PROJECT_TERMS: Address;Adult;autosome;Baltimore;base;biobank;Biological;Biological Markers;Blood Cells;Blood Pressure;Blood Vessels;blood-based biomarker;Cell Culture Techniques;cell immortalization;cellular engineering;Characteristics;Clinical;clinical center;Clinical Data;clinical investigation;clinical phenotype;Clinical Protocols;Clinical Research;Clinical Trials;cohort;Collaborations;Consensus;Cyst;Cyst Fluid;Data Collection;Development;Diagnosis;Disease Pathway;Disease Progression;DNA;Doctor of Philosophy;electronic registry;Electronics;Eligibility Determination;Enrollment;Epidemiology;Epithelial Cells;exome sequencing;experience;Family;Functional disorder;Funding;Future;Gene Expression;Genotype;Goals;health related quality of life;Human;human tissue;Hypertension;innovation;inter-institutional;Investigation;Kidney;Laboratories;laboratory facility;Link;Liquid substance;Liver;liver function;Magnetic Resonance Imaging;Marketing;Maryland;Measurement;Medical;Medical History;Mental Depression;Molecular;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrectomy;Neurocognitive;novel marker;novel therapeutics;observational cohort study;Observational Study;Online Systems;Outcome;Patient Participation;patient/disease registry;Patients;peripheral blood;Pharmacotherapy;Phase;Phenotype;Plasma;Polycystic Kidney Diseases;Primary Cell Cultures;prospective;Protocols documentation;Recording of previous events;recruit;Renal function;Research;Research Personnel;Resources;Retrieval;Robotics;Sampling;screening;Severity of illness;single nucleus RNA-sequencing;Site;Specimen;Standardization;Symptom Burden;Testing;therapeutic target;Tissue Banks;Tissue Sample;tolvaptan;Toxic effect;Translational Research;Translations;Universities;Urine;Validation;Work

PROJECT_TITLE: Clinical and Translational Core


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Lymphatic Research;Nanotechnology;Neurodegenerative;Neurosciences

ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE Nanoscale drug vehicles (i.e. nanocarriers) are used extensively for cell-selective therapies but rarely employed for targeted treatments in the eye. Schlemm's canal endothelial cells hold promise as a cellular target for glaucoma therapy, as their mechanical stiffness is associated with modulation of intraocular pressure. The objective of this proposal is to engineer, and validate in a nonhuman primate model, novel nanocarrier platforms for sustained drug release and gene delivery applications specifically targeting Schlemm's canal cells, offering long term treatment options for glaucoma.

PI_NAMEs: JOHNSON, MARK  (contact);SCOTT, EVAN ALEXANDER

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Actins;Address;Adverse effects;Affect;Animal Model;Animals;anterior chamber;Anti-Hypertensive Agents;Aqueous Humor;Attention;Blood Vessels;Bolus Infusion;Cells;cellular targeting;Clinical;Clinical Trials;Cornea;Corneal Endothelium;corneal epithelium;Cytoskeleton;Diagnostic;dosage;Drug Carriers;Drug Delivery Systems;Drug vehicle;efficacy evaluation;Endothelial Cells;Engineering;Evaluation;Exhibits;Eye;eye chamber;Formulation;Frequencies;Future;Gene Delivery;gene delivery system;gene-targeted therapy;Glaucoma;Histology;Hour;Human;Hydrogels;Hyperemia;In Vitro;in vivo;Injectable;Injections;kinase inhibitor;latrunculin A;Measures;Mechanics;Micelles;Microscopy;Modeling;Monkeys;mouse model;Mus;nanocarrier;nanoscale;non-viral gene delivery;nonhuman primate;novel;Ocular Hypotension;ocular hypotensive;Optical Coherence Tomography;Pathway interactions;Patients;Perfusion;Pharmaceutical Preparations;Phenotype;Physiologic Intraocular Pressure;Plasmids;Population;pressure;Primary Open Angle Glaucoma;Reducing Agents;Reporter;Resistance;Retina;Rho-associated kinase;rhoA GTP-Binding Protein;side effect;Specificity;Structure of sinus venosus of sclera;superresolution microscopy;System;targeted delivery;Therapeutic;Therapeutic Agents;Therapeutic Effect;therapeutic target;Tissues;tonometry;Topical application;Toxic effect;Transfection;ultrasound;uptake;Vascular Endothelial Cell;Visible Radiation;Work

PROJECT_TITLE: A Nanocarrier Platform for Targeting Schlemm's Canal Cells

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Microbiome

ORG_CITY: CLEVELAND

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The widespread oral diseases, cavities and periodontitis, are caused through complex interactions between oral pathogens, commensal bacteria, and the host. This proposal investigates how the genotypic, phenotypic, and transcriptomic diversity of commensal Streptococcus species impacts their interactions with oral pathogens. These studies will broaden our understanding of the role of commensal streptococci in promoting health and disease in the oral cavity, potentially revealing new approaches to improve disease outcomes.

PI_NAMEs: LEWIN, GINA  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Abscess;Actinobacillus actinomycetemcomitans;Animal Model;Area;Behavior;Cell surface;Cells;commensal bacteria;Communities;Complex;Development;Disease;Disease Outcome;Disease Progression;environmental change;Fusobacterium nucleatum;gain of function;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Genomics;Genotype;Goals;Grant;Health;Health Promotion;Heterogeneity;Human;Hydrogen Peroxide;improved;In Vitro;Infection;innovation;Laboratories;Location;loss of function;Measures;Mediating;Mediator;member;Microbe;Microscopy;Modeling;Mouth Diseases;Mus;mutant;novel strategies;Oral;oral behavior;Oral cavity;oral commensal;oral microbial community;oral pathogen;oral streptococci;organic acid;pathogen;Pattern;Periodontitis;Persons;Phenotype;Physiology;Population;Porphyromonas gingivalis;Production;receptor;Research;Research Personnel;Resistance;Role;Severity of illness;Shapes;single-cell RNA sequencing;small molecule;Spatial Distribution;Streptococcus;Streptococcus adhesin;Structure;Taxonomy;Testing;Training;trait;transcriptomics;Variant;Virulence Factors;Work

PROJECT_TITLE: Probing the role of heterogeneity in streptococcal interactions


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Prevention;Rural Health

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative The Discovery Science Collaborative for CKDu is a multi-PI application for the Renal Science Core for the Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium. The Renal Science Core consists of several Core components: Genomics, Pathology, Transcriptomics, Biomarker / Proteomics, Physiology, and Bioinformatics / Data Integration. The RSC team is uniquely poised to work within an NIDDK infrastructure with Field Epidemiology Sites, the Scientific Data Coordinating Center, NIDDK leadership, HHEAR, and the External Oversight Committee to make significant contributions to the CURE Consortium in discovery science and achieve the long-term goal of elucidating the etiology, progression, and heterogeneity of CKDu in agricultural communities.

PI_NAMEs: BHALLA, VIVEK  (contact);FRIEDMAN, DAVID J;WAIKAR, SUSHRUT S.

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Affect;Africa;agricultural community;Agricultural Workers;Agrochemicals;biobank;Bioinformatics;Biological Assay;Biological Markers;biomarker development;biomarker identification;Biopsy;Cells;Central America;Central Asia;Characteristics;Chronic;Chronic Kidney Failure;Clinical;clinical phenotype;Collaborations;Communities;community research;comorbidity;Country;Data;Data Coordinating Center;data integration;Databases;design;Developing Countries;Diabetes Mellitus;diagnostic strategy;digital pathology;Disease;Disease Progression;Electrolytes;emerging pathogen;Environmental Risk Factor;Epidemiology;Etiology;Evaluation;experience;experimental study;Far East;flexibility;Foundations;Functional disorder;Funding;Genetic Predisposition to Disease;Genetic study;Genomics;Geography;Glomerular Filtration Rate;Goals;Heat Stress;Heterogeneity;Hypertension;India;Individual;Inflammatory Infiltrate;Infrastructure;Injury;Injury to Kidney;Institution;International;Investigative Techniques;Kidney;kidney biopsy;Kidney Diseases;Leadership;machine learning algorithm;Manuals;Mass Spectrum Analysis;Metabolic Pathway;metabolomics;Methods;Molecular;molecular pathology;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Nephrology;noninvasive diagnosis;novel imaging technology;outcome prediction;Participant;pathogen;Pathogenesis;Pathology;Patients;Peptide Initiation Factors;Persons;Physiology;Population;Predisposition;Proteins;Proteomics;Recording of previous events;Regulation;Renal function;Reporting;Research;Resources;Risk Factors;Role;Sampling;Science;Serum;single cell sequencing;Site;South America;Sri Lanka;Technology;Time;tool;Toxic Environmental Substances;transcriptomics;Tubular formation;United States National Institutes of Health;urinary;Work;working group


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative While early-stage prostate cancer is commonly treated with anti-hormone therapies, advanced cases develop resistance to these treatments and become more lethal. Our studies focus on novel epigenetic mechanisms that are exploited by hormone-resistant prostate cancer cells to gain growth and invasion advantages. By systematically analyzing the prostate cancer epigenome at an unprecedented level of detail, we will learn what hormone-resistant prostate cancer cells need to survive and inform the design of new potential treatments to benefit advanced prostate cancer patients.

PI_NAMEs: CHEN, ZHONG  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Ablation;advanced prostate cancer;Algorithms;Androgen Antagonists;Androgen Receptor;Androgens;anti-cancer research;Area;ATAC-seq;Award;base editing;Binding;Binding Sites;Biological Assay;cancer cell;Cancer Patient;Chromatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Computer Models;Data;Data Set;design;Development;Enhancers;Environment;Epigenetic Process;epigenome;epigenome editing;epigenomics;Event;experimental study;Funding;genetic regulatory protein;genome-wide;Genomics;Goals;Growth;hormone therapy;Hormones;innovation;Invaded;Laboratories;Learning;Malignant neoplasm of prostate;member;Micrococcal nuclease digestion of chromatin followed by sequencing;Molecular and Cellular Biology;Morbidity - disease rate;novel;Nucleosomes;Patients;Pattern;Positioning Attribute;programs;prostate cancer cell;prostate cancer progression;Prostate Cancer therapy;Proteomics;receptor binding;refractory cancer;Research;Resistance;Resistance development;Role;Series;Specialist;System;Systems Analysis;targeted treatment;Techniques;Therapeutic;Tissues;tool;transcription factor;Transcriptional Regulation;transcriptome sequencing;Translations;Work

PROJECT_TITLE: Systems analysis of the prostate cancer epigenome


ADMINISTERING_IC: AI

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative The goal of this project is to determine the role of specific components of the innate immune response in controlling primate lentivirus infection in natural and unnatural hosts. To accomplish this goal, we will study the molecular details of inhibition in cell culture and use novel chimeric viruses in non-human animal models of AIDS. This proposal will uncover new aspects of host defense against viruses and give a greater understanding of the mechanisms limiting viral host range.

PI_NAMEs: BIENIASZ, PAUL D.;HATZIIOANNOU, THEODORA  (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;acute infection;Affect;Amino Acid Substitution;Animal Model;Attenuated;Bar Codes;Binding;Binding Sites;Biological Models;CD8-Positive T-Lymphocytes;Cell Culture Techniques;cell type;Cells;Chronic;Clinical;Collaborations;CRISPR screen;cross-species transmission;Development;Drug Kinetics;env Gene Products;Exhibits;experimental study;gene product;Genes;Goals;Grant;HIV resistance;HIV-1;Host Defense;Human;Image;In Vitro;in vivo;Infection;Innate Immune Response;Interferon alpha;Interferon Type I;Interferons;Knock-out;Knowledge;Laboratories;Lentivirus Infections;Link;Macaca;Macaca nemestrina;Mediating;Methods;Modeling;Molecular;Molecular Cloning;nonhuman primate;novel;Pathogenesis;Phase;Predisposition;preservation;Primate Lentiviruses;Property;Proteins;Reproducibility;response;Role;simian human immunodeficiency virus;SIV;Testing;Time;tool;transmission process;Variant;Viral;Viral Genes;Viral Physiology;Viral Proteins;viron;Virus;Virus Inhibitors;Virus Replication;Work

PROJECT_TITLE: Effects of Interferon on primate lentiviruses

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The proposed research will enable a better understanding of mechanisms used by viruses to infect specific CNS regions and spread within neurons to disseminate in the brain. This information will be useful for the identification of new drug targets for the treatment of viral encephalitis and the development of precision-guided oncolytic vectors to treat nervous system cancers.

PI_NAMEs: DERMODY, TERENCE S. (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: 3-Dimensional;Adult;Afferent Neurons;Atomic Force Microscopy;Axon;Axonal Transport;Binding;Biophysics;blind;Brain;Brain imaging;Capsid;Capsid Proteins;cell type;Cells;Central Nervous System;Cerebellum;Child;clinical development;CRISPR screen;CRISPR-mediated transcriptional activation;Cryoelectron Microscopy;Cultured Cells;Development;Disease;Double Stranded RNA Virus;Dynein ATPase;Electron Microscopy;Encephalitis;Engineering;experimental study;fast axonal transport;Fiber;genetic manipulation;Genome;Hippocampus;Human;Immunocompetent;Immunoglobulins;In Vitro;in vivo;Infection;Integration Host Factors;Integrins;Intervention;Intramuscular;Knockout Mice;Knowledge;Malignant Neoplasms;Mammals;Mediating;Morbidity - disease rate;mortality;Motor;Mus;Mutagenesis;mutant;Nervous System;Nervous System Disorder;neural;neural circuit;neuronal cell body;Neurons;Neuropathogenesis;neurotropic;neurotropic virus;Neurotropism;neurovirulence;new therapeutic target;Newborn Infant;Oncolytic;oncolytic vector;particle;Pattern;Peripheral;pharmacologic;Population;Predisposition;Process;Proteins;receptor;receptor function;reconstruction;recruit;Reovirus;Reovirus Infections;Research;reverse genetics;Role;Route;screening;Sensory Receptors;Series;Serotyping;Structure;Synapses;Synaptic Transmission;System;targeted treatment;Testing;Thalamic structure;Tissues;transmission process;Tropism;ultra high resolution;uptake;Viral;Viral Encephalitis;Viral Pathogenesis;Virulence;Virus;virus host interaction;Visualization;Work

PROJECT_TITLE: Reovirus Neuropathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-S(02)]


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Infectious Diseases;Vector-Borne Diseases;Women's Health Research

ORG_CITY: DALLAS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: These studies are pertinent to public health since they aim to understand the mechanisms that control reproduction of the human pathogen Schistosoma mansoni. Completion of the proposed research could aid in the discovery of new drugs to combat disease caused by this important human parasite.

PI_NAMEs: COLLINS, JAMES J (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Address;adverse outcome;Affect;Behavior;Blood Vessels;cell type;Cells;combat;Coupling;Cues;Data;Development;Developmental Biology;Disease;egg;Essential Genes;Event;Female;Formulation;gene discovery;Gene Expression;Genes;Genetic Transcription;germline stem cells;GLI gene;Human;human old age (65+);human pathogen;In Vitro;insight;Maintenance;male;Mediating;Modernization;Molecular;Muscle;Muscle Cells;Nature;neglected tropical diseases;Nervous System;Neurons;new therapeutic target;novel;novel therapeutics;Oocytes;organ growth;Parasites;Parasitology;Pathology;Persons;Platyhelminths;Positioning Attribute;Process;Production;Public Health;Reproduction;reproductive;reproductive development;reproductive organ;Reproductive system;Research;response;RNA Interference;RNA interference screen;Schistosoma;Schistosoma mansoni;Schistosomiasis;Sexual Development;Sexual Maturation;Signal Transduction;single-cell RNA sequencing;Somatic Cell;stem;Stimulus;Testing;Tissues;tool;transcription factor;transmission process

PROJECT_TITLE: Characterizing sexual development of the human parasite Schistosoma mansoni

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_DEPT: SOCIAL SCIENCES

PHR: Project Narrative The Duke Center for Population Health and Aging (CPHA) supports rigorous, innovative research in biodemography, life course studies and intergenerational studies to understand the relationship between social and biological factors in healthy aging and longevity, to support and enlarge the community of demographic scientists working in population health, and to accelerate the transfer of research to practice.

PI_NAMEs: LYNCH, SCOTT M. (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Acceleration;Adolescent;Adult;Advisory Committees;Age;Aging;aging demography;aging population;Aleurites;Animal Model;Anthropology;Area;Arts;Award;Behavioral;biodemography;Biological;Biological Factors;Biological Markers;Biology;Biosocial;Birth;career;Centers for Population Health;Child;Cognition;cohort;Cohort Studies;Collaborations;collaborative environment;Communities;Community of Practice;comparative;Comparative Study;cost;Data;Data Analyses;Data Collection;Data Linkages;design;Development;disability;Discipline;early childhood;Economics;Educational workshop;Employment;Ensure;Environment;Event;Extramural Activities;Faculty;Fostering;Funding;Generations;genetic linkage analysis;Goals;Grant;Health;Health and Retirement Study;healthy aging;high risk;Human;Individual;Infrastructure;innovation;Institution;inter-institutional;Interdisciplinary Study;intergenerational;Intergenerational Relations;International;Investments;Leadership;Life Cycle Stages;life span;Longevity;Longitudinal Studies;Mathematics;Measurement;Medical;member;Mental Health;Mentors;Methods;mid-career faculty;middle age;Morbidity - disease rate;Neurosciences;next generation;nonhuman primate;novel strategies;Parents;Peer Review;Personal Satisfaction;physical conditioning;Population;population health;Positioning Attribute;post-doctoral training;pre-doctoral;Primates;Process;professor;programs;psychologic;Psychology;rate of aging;recruit;Research;research data dissemination;Research Personnel;Research Project Grants;Research Support;research to practice;Resources;Role;Rural;Science;Science Policy;Scientist;Services;Shapes;social;social adversity;social factors;Social Well-Being;Sociology;success;Testing;Time;Training;transmission process;Universities

PROJECT_TITLE: Center for Population Health and Aging


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Infectious Diseases;Methamphetamine;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE The fentanyl era has brought a resurgence of bloodborne and sexually transmitted infections and an unprecedented epidemic of overdose mortality, both of which appear to be linked to methamphetamine. Our findings will provide rigorous empirical evidence to policymakers, physicians, health departments, and agencies working with people who inject methamphetamine to help them mitigate attendant health risks. The proposed project will facilitate substance use disorder treatment efforts, infectious disease prevention efforts, screening efforts for chronic fatal conditions, and inform public health interventions that reduce the likelihood of dying of methamphetamine overdose.

PI_NAMEs: KRAL, ALEXANDER H (contact)

PROGRAM_OFFICER_NAME: PARKER, ERIN MARGARET

PROJECT_TERMS: Acute;Address;Adult;Amphetamines;analog;Back;California;Cardiac;Cause of Death;Cerebral hemisphere hemorrhage;Cessation of life;Chronic;cohort;Communicable Diseases;Communities;Data;Death Certificates;Disease Outbreaks;disorder prevention;disorder risk;drug market;Drug usage;Environment;Epidemic;Epidemiologist;epidemiology study;experience;Fentanyl;fentanyl use;follow-up;Funding;Health;Hepatitis C virus;HIV;HIV diagnosis;HIV/HCV;Hospitalization;Illicit Drugs;Indiana;Injecting drug user;Injections;Link;Massachusetts;Medical Examiners;Mental Depression;Methamphetamine;Methamphetamine overdose;methamphetamine use;Methamphetamine use disorder;Methods;mortality;Motivation;National Institute of Drug Abuse;Needle Sharing;opioid epidemic;opioid mortality;Overdose;overdose death;Pain management;Performance;Persons;Pharmaceutical Preparations;Physicians;pleasure;Policy Maker;prevent;Psychiatrist;psychostimulant;Public Health;public health intervention;Publishing;Records;recruit;Reporting;Research Personnel;Risk;Risk Behaviors;risk sharing;Sampling;San Francisco;screening;Sedation procedure;Sexually Transmitted Diseases;sexually transmitted virus;Shapes;Substance Use Disorder;Surveys;timeline;Toxic effect;Toxicology;United States;Update;Urine;Ventilatory Depression;Washington;Weight;West Virginia

PROJECT_TITLE: Methamphetamine injection, associated health risk, and causes of overdose deaths.

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Aging;Clinical Research;Health Services

PROJECT_TERMS: Acceleration;Administrator;Adopted;Advisory Committees;Aging;aging demography;aging population;Area;Arts;Award;Centers for Population Health;cohesion;Collaborations;Collection;Communication;Communities;Data Collection;data management;design;Development;Discipline;Documentation;Effectiveness;Ensure;experience;experimental study;Faculty;Fostering;Funding;Goals;Grant;Health;improved;Information Management;Infrastructure;innovation;Lead;Mediation;novel strategies;Pilot Projects;Population Research;Process;programs;Qualifying;recruit;Research;research and development;Research Institute;Research Personnel;Research Support;Resources;Science;Scientist;Services;social science research;Structure;Students;tool;Universities;Wages;willingness;Work

PROJECT_TITLE: Core A: Admin Core


NIH_SPENDING_CATS: Aging;Clinical Research

PI_NAMEs: CASPI, AVSHALOM  (contact)

PROJECT_TERMS: Aging;aging demography;aging population;Ally;Applications Grants;Area;Centers for Population Health;Collaborations;Communities;Development;Discipline;doctoral student;Educational workshop;Environment;experience;Exposure to;Extramural Activities;Faculty;Funding;Future;Goals;graduate student;Grant;high risk;innovation;interdisciplinary collaboration;interest;Leadership;Mentorship;Methods;Mission;novel strategies;outreach;Peer Review;Pilot Projects;Play;Population Study;Postdoctoral Fellow;pre-doctoral;Program Development;programs;Publications;recruit;Research;research and development;Research Personnel;Research Project Grants;Resources;Role;Schedule;Scholarship;Schools;Scientist;Series;Structure;Testing;Training

PROJECT_TITLE: Core B: Program Development


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Services;Social Determinants of Health

PI_NAMEs: TUNG, JENNY  (contact)

PROJECT_TERMS: Aging;aging population;Ally;Animal Model;Applications Grants;Area;Behavioral;biodemography;Biological;Biological Sciences;Biosocial;career networking;Centers for Population Health;Collaborations;Communities;Country;Demography;Development;Dimensions;doctoral student;Economics;Educational workshop;Event;experience;Faculty;flexibility;Fostering;Foundations;Funding;Germany;Grant;Health;health determinants;Human;human model;Infrastructure;Institution;inter-institutional;interdisciplinary collaboration;interest;International;Joints;Lead;Life;Life Cycle Stages;meetings;National Institute of Child Health and Human Development;next generation;North Carolina;novel strategies;Population;population health;Population Study;Postdoctoral Fellow;pre-doctoral;recruit;Research;Research Personnel;Scientist;social;social health determinants;Social Sciences;Students;support network;symposium;synergism;Teacher Professional Development;Training;Travel;United States;Universities;Visit;Work;working group

PROJECT_TITLE: Core C: External Network Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer;Eye Disease and Disorders of Vision;Orphan Drug;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The goal of this project is to develop bioavailable inhibitors that target specific subtypes of G protein α-subunits, and to dissect their mechanisms of action. The inhibitors and fundamental concepts generated by this project will provide transformative opportunities for drug discovery in a broad spectrum of diseases in which traditional receptor-targeted drugs are inappropriate or have proved ineffective. These diseases include Alzheimer's disease, many cancers, cardiovascular disease, pulmonary disease, inflammatory disorders, diabetes and obesity, and behavioral disorders.

PI_NAMEs: BLUMER, KENDALL J (contact);MOELLER, KEVIN DAVID

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Acute;Address;Alzheimer's Disease;Amino Acids;analog;Animal Disease Models;Antibodies;autosome;Basic Science;Behavior Disorders;Binding;Binding Sites;Biochemical;Biological Assay;Biological Availability;biophysical analysis;Biophysical Process;Biopsy;blood pressure reduction;Cardiovascular Diseases;Cell Line;Cells;Chemical Actions;Chemicals;Chronic;Clinical;Clinical Research;Clinical Trials;computerized tools;cost;Cyclodepsipeptides;design;Diabetes Mellitus;Disease;Docking;Dose Limiting;drug discovery;Drug Targeting;Drug Tolerance;druggable target;effective therapy;Elements;Family;Foundations;Funding;G-Protein-Coupled Receptors;Goals;Growth;GTP-Binding Protein alpha Subunits;GTP-Binding Proteins;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Hemangioma;Hepatic;Heterotrimeric GTP-Binding Proteins;Hormone secretion;Hypocalcemia;Hypoparathyroidism;Individual;Inflammatory;inhibitor;innovation;insight;knock-down;Knock-out;Knowledge;Lethal Dose 50;Lung Diseases;Malignant Neoplasms;Mediating;Melanoma patient;Melanoma Tumor;Modeling;molecular dynamics;mouse model;mucosal melanoma;Mus;mutant;nanoparticle;Natural Products;Neoplasms;novel;Obesity;Oncogenic;Organic Chemistry;pharmacologic;Phase;Physiological;Physiology;Pituitary Neoplasms;pre-clinical;preclinical study;Probability;Process;protein function;Protein Inhibition;receptor;Receptor Signaling;Regulation;respiratory;Route;S phase;side effect;single-molecule FRET;Solid;Source;Sturge-Weber Syndrome;System;targeted delivery;Therapeutic;therapeutic development;therapeutic lead compound;therapeutically effective;Tissues;Toxic effect;tumor;Uveal Melanoma;Visualization;Work;Xenograft Model

PROJECT_TITLE: PHARMACOLOGICAL TARGETING OF GALPHA SUBUNITS IN DISEASE

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Clinical Research;Health Services

PI_NAMEs: HOTZ, VINCENT JOSEPH (contact)

PROJECT_TERMS: Adoption;Aging;aging demography;aging population;Area;Behavior;Brain;Calibration;Centers for Population Health;Chicago;Clinical;Cognition;Cognitive;Collaborations;Collection;Communities;Consent;cost;Cost Analysis;cost effective;Data;Data Collection;data integration;design;Development;dissemination strategy;Educational workshop;Ensure;experience;Family;Fostering;Funding;Future;Grant;Health;health data;health record;healthy aging;Hospitals;improved;Individual;innovation;interest;intergenerational;Internet;Investigation;Laboratories;Learning;Life Cycle Stages;Location;Measurement;Measures;meetings;member;Methods;Monitor;next generation;older adult;operation;Personal Satisfaction;Population;population based;Population Study;Process;Protocols documentation;Publications;Randomized;recruit;Research;Research Personnel;Resources;Respondent;Role;rural setting;Sampling;Series;Shapes;social media;success;summer institute;Surveys;symposium;Testing;Time;Training;Trust;Universities;webinar;Work

PROJECT_TITLE: Core D: External Research and Dissemination Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE This proposal aims to develop novel microbial-based therapeutics that effectively target tumor-associated heparan sulfates driving macropinocytosis and therapeutic resistance in pancreatic cancer. In the short-term, this project will determine the impact of these agents on tumor metabolism and resistance to anabolic inhibitors as well as approaches to advance their clinical translation. In the long-term, these agents can be used to treat patients with highly macropinocytic cancers (Kras-driven) in combination with readily available anabolic inhibitors.

PI_NAMEs: MANUEL, EDWIN  (contact)

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: Affinity;Anabolism;Antimetabolites;Attenuated;Automobile Driving;Autophagocytosis;Binding;Bladder;Breast;cancer therapy;candidate identification;Catabolic Process;Cell Line;Cell Proliferation;Cell surface;Clinical;clinical translation;clinically relevant;Colon;Colorectal Cancer;comparison control;conventional therapy;cost;Culture Media;cytokine;Death Rate;depolymerization;design and construction;Development;Disease;Drug resistance;Endocytosis;Engineering;Enzymes;experience;extracellular;Extracellular Matrix;Fluorouracil;gemcitabine;Gene Expression;Genes;Glucosamine;Glucuronic Acids;Goals;Growth;Growth Factor;Heparan Sulfate Proteoglycan;heparanase;Heparin Lyase;heparinase III;Heparitin Sulfate;Homeostasis;in vivo;ineffective therapies;inhibitor;Invaded;Investigational Drugs;KRAS oncogenesis;Lesion;Lung;Lysosomes;macromolecule;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Manuals;manufacture;Measures;Mediating;Mediator;Metabolic;Metabolism;Methods;microbial;microbial based therapy;Modification;Monomeric GTP-Binding Proteins;mouse model;mutant;National Cancer Institute;Neoplasm Metastasis;neoplastic cell;neovascularization;novel;novel strategies;Nutrient;Oncogenic;Outcome;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway interactions;patient derived xenograft model;Patients;Plasmids;Process;Production;Prognosis;Proliferating;promoter;Prostate;Proteins;receptor;Recombinants;Recurrent disease;Regenerative capacity;Research;Resistance;response;Salmonella typhimurium;Signal Transduction;Signaling Molecule;Source;standard of care;Stress;Structure;syndecan;targeted agent;targeted treatment;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Therapeutic Use Study;therapeutically effective;therapy resistant;tumor;tumor growth;tumor metabolism;tumor microenvironment;tumor progression;Tumor Tissue;tumorigenic;vector;Vertebral column;Work;Xenograft Model

PROJECT_TITLE: Development of Microbial-Based Therapies to Suppress Macropinocytosis in Kras-Driven Cancers

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Complementary and Integrative Health;Digestive Diseases;Hematology;Infectious Diseases;Microbiome;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Sepsis

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Targeting the Intestinal Mucosa and Microbiome to Prevent Neonatal Late-onset Sepsis. Late- onset sepsis (LOS) is a leading cause of morbidity and mortality in premature infants that arises in the context of dysbiosis of the developing intestinal microbiome. This project will elucidate mechanisms that predispose to neonatal dysbiosis with the goal of preventing neonatal LOS.

PI_NAMEs: GRAY, MICHAEL JEFFREY;WEAVER, CASEY T (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Adult;age related;Alabama;Anaerobic Bacteria;Anaerobiosis;Animal Model;Antibiotics;Automobile Driving;Biology;candidate identification;Cell Maturation;Cells;Child;Clinical;clinically relevant;Collaborations;commensal bacteria;commensal microbes;design;Development;Disease;Disparate;Dose;dysbiosis;electron donor;enteric infection;Enterobacteriaceae;Epithelial Cells;Epithelium;Family;Foundations;Future;Genes;Genetic;Genetic Transcription;Goals;Growth;gut dysbiosis;gut inflammation;gut microbes;gut microbiome;high risk infant;human disease;Immune;Immunity;Incidence;Infant;Infection;Inflammation;insight;interdisciplinary approach;Intervention;intestinal epithelium;Intestinal Mucosa;Intestines;Klebsiella pneumoniae;lactic acid bacteria;Lactobacillus;late onset sepsis;Link;Mediating;Metagenomics;microbial;Microbial Genetics;microbial genomics;microbiome;microbiota;Molecular;Morbidity - disease rate;mortality;mouse model;Neonatal;neonate;Neonatology;novel;Outcome;Oxidants;Oxidation-Reduction;Oxygen;pathobiont;Pathway interactions;Patients;prebiotics;Predisposition;Premature Infant;prevent;Prevention;Probiotics;programs;rational design;Research;Research Personnel;Respiration;respiratory;Sampling;Science;Sepsis;Signal Transduction;Staphylococcaceae;Testing;Therapeutic Intervention;Translating;Variant;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(91)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Cancer mutations drive the outgrowth of small populations of cells in normal tissue, years before clinical diagnosis of cancer, or the outgrowth of cells resistant to therapy. However, how such mutations change cellular behavior to provide them with a competitive growth advantage over adjacent cells remains poorly understood. To address this gap in knowledge, we propose to apply and develop novel single-cell sequencing technologies to study the mechanisms underlying growth advantage in cancer.

PI_NAMEs: LANDAU, DAN  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Address;Admixture;Adoption;Affect;analytical method;Awareness;Biological Assay;Bone Marrow;cancer diagnosis;cancer genomics;cancer therapy;cell behavior;Cell Physiology;Cell surface;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chromatin;Chronic Lymphocytic Leukemia;clinical diagnosis;Clonal Evolution;Clonal Expansion;Development;Disease Resistance;driver mutation;Epigenetic Process;epigenomics;Evolution;experience;fitness;Frequencies;Genes;Genetic;Genetic Heterogeneity;Genetic Transcription;Genotype;Goals;Growth;Hematopoiesis;hematopoietic differentiation;Heterogeneity;Human;Human body;human tissue;Immune system;Individual;Knowledge;Lead;Link;Malignant - descriptor;Malignant Neoplasms;methylome;Minority;Molecular;Mosaicism;multiple omics;mutant;Mutate;Mutation;Myeloproliferative disease;Nature;Normal Range;Normal tissue morphology;novel;Output;Phenotype;phenotypic biomarker;Population;protein expression;Proteins;Resistance;Resolution;Risk;RNA Splicing;Sampling;Signal Transduction;single cell ATAC-seq;single cell genomics;single cell sequencing;single cell technology;single-cell RNA sequencing;Slide;Somatic Mutation;Spatial Distribution;targeted treatment;Technology;therapy development;therapy resistant;Time;Transcript;transcription factor;transcriptome;transcriptomics;Variant

PROJECT_TITLE: Expanding the GoT toolkit to link single-cell clonal genotypes with protein, transcriptomic, epigenomic and spatial phenotypes


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Parental feeding behaviors (PFB) are a potential link connecting food insecurity with pediatric obesity. The proposed work will: 1) examine the relationship between food insecurity and parental feeding behaviors in a longitudinal cohort; and 2) develop and pilot a novel intervention which addresses food insecurity and parental feeding behaviors through resource connection and peer support to prevent obesity.

PI_NAMEs: ORR, COLIN JAMES (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: acceptability and feasibility;Address;Affect;American;Attitude;behavior change;Behavioral;Black race;career development;Child;Child Development;Child Health;Chronic Disease;Clinical;cohort;Communities;COVID-19 pandemic;Cross-Sectional Studies;Cues;Data;design;Development;Development Plans;Diabetes Mellitus;disparity reduction;Economics;effective intervention;Electronics;Elements;Ensure;ethnic diversity;ethnic minority population;experience;Family;feeding;Feeding behaviors;Food;food insecurity;food security;Funding;Future;Gills;Goals;Grant;Growth;Growth and Development function;health disparity;healthy weight;High Prevalence;Hispanic;Household;Hunger;implementation intervention;implementation science;improved;Infant;infant adiposity;innovation;Intervention;K-Series Research Career Programs;Knowledge;learned behavior;Learning;Length;Life;Link;Literature;longitudinal analysis;Longitudinal cohort;Manuscripts;Measures;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;National Institute of Diabetes and Digestive and Kidney Diseases;North Carolina;Not Hispanic or Latino;novel;nutrition;Obesity;obesity in children;obesity prevention;obesity risk;obesity treatment;Outcome;Parents;Pathway interactions;patient population;pediatrician;peer;peer support;Perception;Physicians;Pilot Projects;Positioning Attribute;preference;prevent;Public Health;Qualitative Methods;Questionnaires;racial diversity;racial minority population;Randomized, Controlled Trials;recruit;Reporting;Research;Research Personnel;Research Support;Resources;Schools;Science;skill acquisition;Strategic Planning;Testing;theories;Theory of Change;therapy design;therapy development;Time;Training;Universities;Weight;Weight Gain;Work;Writing

PROJECT_TITLE: Understanding and Addressing Food Insecurity and Obesity Among Infant-Parent Dyads

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE There is a growing body of evidence that smooth muscle cell phenotypic transitions play an important role in the pathogenesis of atherosclerosis. However, little is known about endogenous factors responsible for these transitions in vivo within the blood vessel wall. This research project will define whether innate immune mechanisms induce atheroprotective changes in smooth muscle cells.

PI_NAMEs: CHEREPANOVA, OLGA  (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: antagonist;ApoE knockout mouse;Apolipoprotein E;Area;Arterial Fatty Streak;Arteries;atheroprotective;Atherosclerosis;ATP binding cassette transporter 1;Automobile Driving;Blood Vessels;Cell Lineage;cell motility;Cells;Cholesterol;chromatin immunoprecipitation;Coronary artery;cytokine;Data;Differentiation Antigens;Disease;embryonic stem cell;Endogenous Factors;Epigenetic Process;Feedback;Genetic;Genetic Transcription;Human;Immune;Impairment;In Vitro;in vivo;indexing;induced pluripotent stem cell;Inflammatory;Inflammatory Response;innate immune mechanisms;insight;Investments;IRF3 gene;Knock-out;Knockout Mice;Lead;Lesion;Lipids;Lipopolysaccharides;LXRalpha protein;Macrophage;Mediating;member;Molecular;mouse model;Mus;Natural Immunity;NF-kappa B;novel;overexpression;Pathogenesis;Pathway interactions;Phagocytosis;pharmacologic;Phenotype;Phospholipids;Play;pluripotency factor;Production;promoter;Reporting;Research Project Grants;response;Role;Signal Transduction;Smooth Muscle Myocytes;Somatic Cell;Specimen;Stem Cell Factor;Stem cell pluripotency;Stimulus;Testing;Time;TLR4 gene;Toll-like receptors;transdifferentiation;Up-Regulation;virtual

PROJECT_TITLE: Role of the TLR4 signaling in smooth muscle cell phenotypic transition

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: RELEVANCE TO PUBLIC HEALTH Advances in experimental techniques to modify the genetic makeup of mice have enabled development of mice that “model” particular diseases, including cancers, providing live organisms that researchers can use to study disease progression and test therapies. However, a major roadblock in the development of such models is the inefficiency of inserting large tracts of DNA into mouse chromosomes, a limitation that hinders research on the role of many coding and non-coding DNA regions in cancer. In the proposed project we will develop, validate, and make publically available an innovative technique for precise insertion of large tracts of DNA into mouse chromosomes, enabling researchers to develop improved and new models of cancer.

PI_NAMEs: HOSUR, VISHNU  (contact)

PROJECT_TERMS: Address;Animals;arm;Bacteria;blastocyst;Breast Cancer Model;Cancer Model;Cell Line;Chromosomes;Code;Collaborations;Communities;Congenital Megacolon;Couples;Cre lox recombination system;CRISPR/Cas technology;Development;digital;Disease;disease model;Disease Progression;DNA;DNA Integration;DNA Sequence;Electroporation;Engineering;Enhancers;Excision;experimental study;Fluorescence Microscopy;Future;Gene Rearrangement;Gene Transfer Techniques;Generations;Genes;Genetic Engineering;genetic makeup;Genetic Recombination;Genetic Transcription;genetic variant;Genome;genome editing;Genomics;Germ Lines;Goals;Guide RNA;Human;human disease;human induced pluripotent stem cells;human model;human stem cells;improved;induced pluripotent stem cell;innovation;Integrase;Left;Length;Link;Literature;Malignant Neoplasms;Mediating;Microinjections;Modeling;mouse development;Mouse Embryonic Stem Cells;mouse genome;mouse model;multidisciplinary;Mus;nanopore;novel;Organism;Play;prevent;Protocols documentation;Public Health;Reaction;recombinase;repaired;Reporter;Research;Research Personnel;Resource Development;risk variant;Role;Serine;Site;site-specific integration;stem cell model;success;System;Techniques;Technology;Testing;tool;tool development;Toxic effect;Transgenic Mice;transmission process;Transposase;triple-negative invasive breast carcinoma;Untranslated RNA;Variant;Viral;Work;zygote

PROJECT_TITLE: Site-specific Integration of Large (10-100 kb) DNA Constructs into the Mouse Genome and Human Induced Pluripotent Stem Cells Using the Cas9-Bxb1 Integrase Toolbox


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Prevention;Social Determinants of Health

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Chronic kidney disease of uncertain etiology (CKDu) is endemic in many countries , particularly in coastal agricultural communities near the equator. The proposed field center in Uddanam, South India will recruit, examine and follow patients with CKDu, compared them with healthy controls in an effort to identify the causes and risk factors for CKDu. The findings of this study will provide information necessary for the prevention and treatment of this debilitating disease that is associated with significant disability and increased mortality.

PI_NAMEs: JHA, VIVEKANAND ;MOHAN, SUMIT  (contact);NAVAS-ACIEN, ANA ;VAN GEEN, ALEXANDER FRANS

PROJECT_TERMS: Address;Adult;Affect;Age;age group;agricultural community;Agriculture;Air;Alcohols;Analgesics;Area;Biological Markers;Biopsy;Blood;case control;Chronic Kidney Failure;Clinical;clinical examination;cohort;Cohort Studies;Collaborations;Collection;Communities;community engagement;Country;Coupled;Cross-Sectional Studies;Data;design;Development;Diabetes Mellitus;disability;Disease;Disease Progression;Dose;Education;Environment;Environmental and Occupational Exposure;Environmental Epidemiology;Environmental Exposure;Environmental Risk Factor;Environmental Science;epidemiology study;Etiology;Evaluation;experience;Family;First Degree Relative;follow-up;Frequencies;Future;Gender;General Population;Genes;Genetic;genetic pedigree;Genetic Predisposition to Disease;genetic risk factor;Glomerular Filtration Rate;Hair;Health system;Healthcare Systems;Heat Stress;Hematuria;Heterogeneity;Household;Hypertension;India;Individual;Infection;Injury;Injury to Kidney;Intervention;kidney biopsy;Kidney Diseases;Leadership;Location;longitudinal analysis;Longitudinal Studies;low socioeconomic status;Manuals;Measurement;Measures;Medical;Medical History;member;mortality;multidisciplinary;Nail plate;Non-Steroidal Anti-Inflammatory Agents;Occupational;Occupations;Participant;Pathway interactions;patient subsets;Patients;Pattern;Perception;Pesticides;Phenotype;phenotypic data;Poison;pollutant;Population;Predisposition;Prevalence;Prevention;Preventive;programs;progression risk;prospective;Proteinuria;Protocols documentation;Public Health;public health intervention;Questionnaires;Recording of previous events;recruit;Renal function;Research;Resource-limited setting;Risk Factors;sample collection;Sample Size;Sampling;Seasonal Variations;Seasons;sex;Silicones;Soil;Specific qualifier value;Spouses;Standardization;State Government;Sustainable Development;Testing;therapy design;Time;Tobacco smoking behavior;Translating;Urine;Visit;Water;Work

PROJECT_TITLE: India - Factors of CKDu in Uddanam Study (India-FOCUS)


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Mental Health;Neurosciences;Social Determinants of Health

ORG_DEPT: PSYCHOLOGY

PHR: NARRATIVE The purpose of this project is to enhance rigorous scientific training in neuroscience and create an environment for all to thrive at Duke University. Specifically, we aim to change the culture of science, embrace and engage students from backgrounds under-represented in science together with their peer colleagues and mentors, and improve the academic scientific training environment in neuroscience for all.

PI_NAMEs: ADCOCK, RACHEL ALISON;SAMANEZ LARKIN, GREGORY R (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Accountability;Achievement;Attention;Award;career;career development;Clinical;cohort;combat;Communities;community intervention;cultural values;Data Science;Decision Making;Dehumanization;Destinations;Development;disadvantaged student;Distress;Elements;Emotional;Empathy;Ensure;Environment;equity, diversity, and inclusion;Face;Faculty;flexibility;Funding;Goals;graduate student;Growth;Image;improved;Individual;Infrastructure;innovation;Institution;Intervention;Learning;Mental disorders;Mental Health;Mentors;Methods;Minority Graduate Student;minority student;minority trainee;Modeling;Motivation;Neurosciences;Occupations;open data;Outcome;Pain;peer;Performance;permissiveness;Personal Satisfaction;Postdoctoral Fellow;Problem Solving;Productivity;programs;Publications;racism;recruit;remediation;Resources;Risk;scaffold;Science;science education;Scientist;skills;skills training;social;social cohesion;student participation;Students;success;System;Testing;therapy design;Training;Training and Infrastructure;Underrepresented Populations;Underrepresented Students;Universities;Work

PROJECT_TITLE: Duke Impact Neuroscience Program


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Osteoarthritis;Pain Research;Prevention

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The current proposal will establish a powerful non-invasive imaging biomarker based on development of rapid isotropic resolution, simultaneous morphological and multicomponent relaxation mapping with compressed sensing.

PI_NAMEs: REGATTE, RAVINDER  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;articular cartilage;Binding;Biochemical;Biological Models;Bovine Cartilage;Cartilage;cartilage degradation;Clinical;Clinical Protocols;cohort;Collagen;Collagen Fiber;Data;data space;Debility;Degenerative polyarthritis;Development;Diagnostic;Disease;Early Diagnosis;efficacy evaluation;Evaluation;Extracellular Matrix;Future;Goals;healing;Healthcare Systems;Histology;Human;Hydration status;Image;imaging biomarker;Imaging Techniques;improved;in vivo;Joints;Knee joint;Knee Osteoarthritis;Lead;macromolecule;Magnetic Resonance Imaging;Maps;Meniscus structure of joint;Methods;Modeling;Morphology;morphometry;Musculoskeletal;Non-Invasive Detection;non-invasive imaging;novel;Outcome;Pain;Pathologic Processes;Patients;Performance;personalized medicine;Persons;Population;premature;prevent;Proteoglycan;Protocols documentation;reconstruction;Relaxation;repaired;Research Personnel;Resolution;Sampling;Scanning;Slice;Specificity;Structure;T2 weighted imaging;Techniques;Therapeutic Agents;Thick;Time;Tissue Engineering;Tissues;Translating;Treatment Protocols;United States;Validation;Water

PROJECT_TITLE: Rapid Quantitative Assessment of Knee Joint with Compressed Sensing

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE/ LAY SUMMARY This application examines the mechanisms by which nutrient excess and obesity cause liver damage with tissue inflammation and scarring. We propose that liver fat accumulation stimulates pro-death signaling cascades, thereby causing liver cells to release molecules that induce inflammation via the invasions of white blood cells and that inhibition of these processes prevents liver injury and its sequelae. The results of these preclinical studies are germane to mechanisms of liver injury in the common syndrome of nonalcoholic fatty liver disease and have the potential to identify new therapeutic strategies for treating human liver disease.

PI_NAMEs: HIRSOVA, PETRA  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Ablation;Activated-Leukocyte Cell Adhesion Molecule;Adaptive Immune System;Animal Model;Attenuated;CASP6 gene;Caspase;CD4 Positive T Lymphocytes;CD6 antigen;Cell Death Induction;Cell Membrane Permeability;Cell model;Cellular biology;Cellular Stress;Cessation of life;Cicatrix;Data;design;extracellular vesicles;Fatty acid glycerol esters;Fibrosis;Genetic;Goals;Hepatic;Hepatocyte;Human;human disease;immune cell infiltrate;Immunophenotyping;In Vitro;Infiltration;Inflammation;Innate Immune System;innovation;insight;intercellular communication;Invaded;Leukocytes;Link;Lipids;Liver;Liver diseases;Liver Fibrosis;liver inflammation;liver injury;Macrophage;major outer membrane protein;Mediating;migration;Minority;Modeling;Molecular;monocyte;mouse model;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel therapeutic intervention;Nutrient;Obesity;Outer Mitochondrial Membrane;Pathogenesis;Pathogenicity;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;Play;preclinical study;prevent;Process;Protein Kinase;receptor;recruit;Research;response;rho;ROCK1 gene;Role;Severity of illness;Signal Induction;Signal Transduction;Specimen;Syndrome;T cell infiltration;T-Lymphocyte;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;Work

PROJECT_TITLE: Pathobiology of Nonalcoholic Steatohepatitis

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

PHR: PROJECT NARRATIVE Dengue virus (DENV) is a pathogen of high biomedical significance against which we lack effective vaccines and antivirals. Since conventional antiviral approaches have to date not been successful, we propose to develop small molecules antivirals that act by inducing specific degradation of viral proteins. This work will examine the advantages of this approach over conventional inhibitors and establish pharmacological degradation of viral proteins as an antiviral strategy.

PI_NAMEs: GRAY, NATHANAEL SCHIANDER;YANG, PRISCILLA LI-NING (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Ablation;Affect;Affinity;Anti-viral Agents;anti-viral efficacy;Anti-viral resistance;antiviral drug development;Binding;Biological Assay;Cancer Biology;Cell Culture Techniques;Cells;chemotherapy;combat;cytotoxicity;Dengue;Dengue Infection;Dengue Virus;Development;Dose;Drug Kinetics;efficacy testing;Event;Excision;Experimental Designs;Flavivirus;Foundations;Genetic Variation;Genotype;Goals;Hepatitis C;Hepatitis C virus;HIV;Human;improved;In Vitro;in vivo;inhibitor;Length;Ligands;Link;Mediating;Membrane;Methods;Monitor;mouse model;mutant;Mutation;pathogen;pathogenic virus;Peptide Hydrolases;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Polymerase;Predisposition;Process;protein degradation;Proteins;recruit;residence;resilience;Resistance;resistance mechanism;Resistance profile;RNA replication;RNA Viruses;RNA-Directed RNA Polymerase;Serial Passage;Serotyping;small molecule;Specificity;Suppressor Mutations;Testing;tool;ubiquitin-protein ligase;Ubiquitination;vaccine development;Vaccines;Viral;Viral Genome;Viral Physiology;Viral Proteins;Virus;virus core;Virus Replication;Work

PROJECT_TITLE: Small molecule-induced degradation of dengue proteins as an antiviral strategy

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The results of this project will contribute to understanding molecular mechanisms of the actin cytoskeleton, a major cellular system playing critical roles in every aspect of cell physiology. Aberrations in actin cytoskeleton structure, functions and/or dynamics contribute significantly to human pathologies, especially to cancer and neurodegenerative, immune and cardiovascular diseases. Therefore, understanding of actin cytoskeleton functions will help to develop diagnostic and treatment strategies for human disease.

PI_NAMEs: SVITKINA, TATYANA  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Address;Architecture;Biochemical;Biological;cancer cell;Cardiovascular Diseases;Categories;cell motility;Cell Physiology;cell type;Cells;Clathrin;combat;Cytoskeleton;diagnostic strategy;Electron Microscopy;Filament;Goals;high resolution imaging;human disease;Human Pathology;Image;Immune System Diseases;insight;Knowledge;Link;Malignant Neoplasms;mechanical properties;Mechanics;Membrane;Methods;Microfilaments;Microtubules;migration;Molecular;Morphogenesis;Myosin Type II;Neurodegenerative Disorders;non-muscle myosin;Normal Cell;Organelles;paralogous gene;Platinum;Play;Positioning Attribute;Proteins;Research;Resistance;Role;Shapes;Structure;System;Tissues;treatment strategy;virtual

PROJECT_TITLE: Structure and functions of the actin cytoskeleton

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Los Angeles

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: This is a proposal to study the formation of the sutures that separate and grow the skull bones. Our over-arching goal is to broadly understand how distinct genetic mutations cause craniosynostosis by disrupting distinct embryonic processes, with a particular focus on coronal suture fusions in Saethre-Chotzen Syndrome. A better understanding of how particular mutations disrupt suture formation should aid in developing patient-specific approaches toward preventing post-operative fusions of sutures.

PI_NAMEs: CRUMP, GAGE D (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Acceleration;Address;Affect;Alleles;antagonist;base;bone;Bone Growth;Brain;cell motility;cell type;Cells;Chotzen Syndrome;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;Complex;Congenital abnormal Synostosis;Congenital Abnormality;coronal suture;coronal synostosis;craniofacial;Craniosynostosis;cranium;Data;Defect;Development;DNA Sequence Alteration;early childhood;Embryo;embryo cell;embryonic stem cell;Etiology;Excision;Family;Fetal Development;Fishes;flexibility;Functional disorder;Funding;Genes;Genetic;Goals;Growth;Human;Human Genetics;Image;Impaired cognition;in vivo;Individual;Infant;Intellectual functioning disability;Joint structure of suture of skull;Joints;Left;Legal patent;Link;Live Birth;Measurement;model organism;Modeling;Molecular;molecular marker;Monitor;mouse model;Mus;Mutagenesis;mutant;Mutation;Operative Surgical Procedures;Orthologous Gene;Osteoblasts;Osteogenesis;Patients;Phenocopy;postnatal;Postoperative Period;premature;preservation;prevent;Process;progenitor;programs;quantitative imaging;Regulation;Repeat Surgery;Reporter Genes;restraint;Role;Signal Transduction;single cell genomics;single-cell RNA sequencing;Source;stem cell biology;stem cells;Structure;Surgical sutures;suture fusion;targeted treatment;Testing;therapy development;tool;transcription factor;transcriptome;Transgenic Organisms;TWIST1 gene;Up-Regulation;Validation;Work;Zebrafish

PROJECT_TITLE: Molecular and Cellular Basis of Craniosynostosis

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Mental Illness;Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CHARLESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Narrative: The goal of the proposed studies is to better understand the cortical changes in excitatory-inhibitory balance that may underlie the cognitive deficits elicited by METH abuse. Furthermore, since cognitive deficits occur not only in psychostimulant abusers but also in a variety of different neurodevelopmental disorders, the knowledge generated by this proposal may provide new pharmacotherapeutics targets for multiple disorders that produce cognitive dysfunction.

PI_NAMEs: LAVIN, ANTONIETA  (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Acute;addiction;antagonist;Anxiety;Attention;autism spectrum disorder;Bathing;Behavior;behavior test;Biological Markers;Brain;cell type;Chronic;Cognitive;Cognitive deficits;cognitive disability;cognitive function;Cues;Data;Disease;Dopamine D1 Receptor;effective therapy;Electrophysiology (science);Equilibrium;Executive Dysfunction;executive function;experimental study;Face;frontal lobe;Functional disorder;Genetic;Goals;hippocampal pyramidal neuron;Impaired cognition;Impulsivity;insight;interest;Interneurons;knock-down;Knowledge;Literature;Maintenance;Mediating;Medical;Memory impairment;Mental Depression;Methamphetamine;methamphetamine abuse;Methamphetamine dependence;methamphetamine effect;N-Methylaspartate;Neurodevelopmental Disorder;neuropsychiatric disorder;neuropsychiatry;novel;novel therapeutic intervention;Parvalbumins;Pathologic;Pathology;Pharmaceutical Preparations;pharmacologic;Play;Prefrontal Cortex;Preparation;Psychoses;psychostimulant;Rat Transgene;Rattus;Reagent;Receptor Activation;receptor function;Receptor Signaling;Research;Rodent;Role;Schizophrenia;Self Administration;Short-Term Memory;Slice;Social Functioning;Stimulus;Study models;Substance Use Disorder;Symptoms;Synapses;Synaptic Transmission;Techniques;Testing;theories;tool;transmission process;Viral;Whole-Cell Recordings

PROJECT_TITLE: Methamphetamine Effects on Prefrontal Cortical  PV+ Interneurons and Resulting Cognitive Deficits

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Substance Misuse

PHR: Project Narrative Dysfunctional hedonic processing is associated with numerous psychiatric illnesses including substance use disorders (SUDs), alcohol abuse, and depression. Here, we employ a multifaceted neuroscience approach to examine the role of discrete prefrontal neural circuits in negative affective processing, and how strengthening disrupted neural signaling in those systems can reduce negative affect. This work will provide critical insight into effective treatment strategies to restore normal hedonic processing and aid in the recovery of maladaptive behaviors contributing to psychiatric illnesses.

PI_NAMEs: CARELLI, REGINA M (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Affect;Affective;Alcohol abuse;Alcohol consumption;Anhedonia;Animals;Appetitive Behavior;Automobile Driving;Behavior;Cephalic;Cessation of life;cognitive control;comorbidity;cortico-limbic circuits;Deaths of despair;Disease;drug relapse;Drug usage;drug withdrawal;effective therapy;Electrophysiology (science);Emotional;experience;Extinction;Foundations;Frequencies;Goals;Health;hedonic;Human;Impairment;insight;Learning;learning extinction;Link;maladaptive behavior;Measures;Medial;Mediating;Mental Depression;Mental disorders;Methods;negative affect;negative emotional state;negative mood;neural circuit;neuromechanism;Neurophysiology - biologic function;Neurosciences;neurotransmission;nonhuman primate;novel;Nucleus Accumbens;Optics;optogenetics;Pathway interactions;Play;pleasure;Prefrontal Cortex;preservation;Rattus;Recovery;Regulation;restoration;reward processing;Rewards;Role;sex;Signal Transduction;Substance Use Disorder;Suicide;System;Taste aversion;Taste Perception;Time;treatment strategy;United States;Work

PROJECT_TITLE: Corticolimbic Circuits in Negative Affect

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Genetics

ORG_DEPT: VETERINARY SCIENCES

PHR: Our studies will determine how YY1 controls long-distance chromatin interactions needed of B lineage commitment and for immunoglobulin kappa locus contraction. Defects in these processes can cause immune deficiency and development of lymphoma and leukemia. These studies may define new mechanisms for regulating genomic structure that may be applicable to other systems, and will be relevant to disease formation.

PI_NAMEs: ATCHISON, MICHAEL LEE (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: 3-Dimensional;Ablation;B-Cell Development;B-Lymphocytes;Biological Assay;Bone Marrow;Cell Line;Cell Lineage;Cell Maintenance;Cells;Chromatin;Chromatin Structure;conditional knockout;Coupled;Data;Defect;Development;Disease;Distal;DNA Binding;Embryonic Development;Epigenetic Process;Erythroid Cells;experimental study;Future;Gene Expression;Gene Expression Profile;Gene Rearrangement;Generations;Genes;Genetic Transcription;Genomics;Hematopoietic;Hematopoietic stem cells;IgK;IGK@ gene cluster;immunodeficiency;In Vitro;in vivo;in vivo evaluation;insight;knock-down;Knock-out;Laboratories;leukemia/lymphoma;Lymphoid;Macrophage;Mediating;Megakaryocytes;Modeling;Mus;mutant;neutrophil;notch protein;Nuclear;Pathway interactions;Pattern;permissiveness;Play;Polycomb;prevent;Process;progenitor;programs;Regulation;Repression;Role;Signal Transduction;Specific qualifier value;stem cells;Structure;System;T-Lymphocyte;Testing;Therapeutic;Tissues;Transcript;transcription factor;Transcription Initiation;Transcriptional Activation;YY1 Transcription Factor

PROJECT_TITLE: YY1-dependent chromatin structure stabilization of B lineage commitment

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Services;Prevention

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PI_NAMEs: CANTLEY, LLOYD G (contact);EDELMAN, E. JENNIFER;SHAPIRO, EUGENE DAVID

PROGRAM_OFFICER_NAME: MERCHANT, CAROL

PROJECT_TERMS: Achievement;Affect;Behavioral;Biological;Biomedical Engineering;career;career development;Clinical Research;clinical training;Communities;Coupled;Data Science;Development;Discipline of Nursing;Doctor of Philosophy;Education;experience;Fostering;Goals;Grant;Health;Health Policy;Health system;Human;improved;Individual;Instruction;Intervention;Learning;medical schools;Medicine;Mentors;multidisciplinary;National Research Service Awards;next generation;Physicians;Policies;Population;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Preventive;programs;Psychology;Public Health;Reduce health disparities;Research;Research Personnel;Scholars Program;Science;social;TNFSF15 gene;Training;training opportunity;Training Programs;Training Support;Translating;Translational Research;translational scientist

PROJECT_TITLE: J. NRSA Training Core


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Neurosciences;Stroke

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Stroke is the second leading cause of death and disability worldwide, and the highest rates of stroke and greatest stroke-related morbidity and mortality are found in low- and middle-income countries (LMICs). While effective systems of care to improve stroke outcomes exist in high-income countries, they are lacking in most LMICs. I propose to understand current stroke care practices at the University Teaching Hospital in Lusaka, Zambia, convene a stroke working group to adapt international stroke guidelines to the Zambian setting, and evaluate their impact on stroke-related outcomes.

PI_NAMEs: SAYLOR, DEANNA RAE (contact)

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Achievement;Acute;acute stroke;Address;Admission activity;Adopted;Adult;Africa South of the Sahara;Age;Alteplase;Area;Attention;Award;Biological;Biology;care delivery;care systems;Caregivers;Caring;Cause of Death;Cessation of life;clinical care;clinical implementation;clinical practice;Clinical Practice Guideline;Clinical Research;clinical trial implementation;clinically relevant;cohort;Collaborations;Communities;contextual factors;Country;Data;Dependence;design;Development;disability;effectiveness trial;Enrollment;epidemiology study;Ethnic Origin;evidence base;experience;Focus Groups;functional outcomes;Future;global health;Goals;Guideline Adherence;Guidelines;Health Personnel;Health system;HIV;Hospital Referrals;Hospitals;implementation evaluation;implementation framework;implementation process;implementation research;implementation science;improved;improved outcome;Income;inpatient service;Inpatients;Institutionalization;International;Intervention;Interview;Knowledge;Literature;low and middle-income countries;Maps;Measures;medical schools;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;Nervous System Disorder;neuroimaging;Neurologic;Neurology;observational cohort study;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Persons;Population Heterogeneity;Positioning Attribute;post intervention;Prevalence;primary outcome;Process;professor;programs;Prospective cohort;Provider;Research;Research Methodology;Research Personnel;Research Training;Resources;Rheumatic Heart Disease;Risk Factors;secondary outcome;Secondary to;Services;skills;Southern Africa;Specialist;Standardization;Stroke;stroke intervention;stroke outcome;stroke patient;System;Systems Development;Teaching Hospitals;Training;Training Programs;treatment strategy;Universities;uptake;Work;working group;Working stroke;Zambia

PROJECT_TITLE: Adaptation and Implementation of Clinical Practice Guidelines to Improve Stroke Outcomes in Zambia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-L(57)R]


NIH_SPENDING_CATS: Asthma;Genetics;Infectious Diseases;Lung;Prevention;Social Determinants of Health

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE  The long-term objective of this project is to investigate the fundamental mechanisms underlying the etiology of allergic airway diseases. Specifically, we will investigate how the exposure of airway epithelium to environmental allergens initiates the immune responses that culminate in the disease process. Successful completion of this project will provide new prevention and treatment strategies for these diseases.

PI_NAMEs: KITA, HIROHITO  (contact);O'GRADY, SCOTT M.

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Adjuvant;Affect;Air Pollution;airborne allergen;Airway Disease;airway epithelium;Allergens;Allergic;allergic airway disease;allergic airway inflammation;Aluminum;Animal Model;Apoptosis;Asthma;Atmosphere;bronchial epithelium;Calpain;CASP3 gene;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Cellular biology;Cellular Stress;Chromosomes;chronic rhinosinusitis;Collaborations;cytokine;Development;Disease;disease model;DNA;DNA receptor;ds-DNA;environmental allergen;Environmental Risk Factor;Epithelial Cells;Epithelium;Etiology;Exons;experimental study;Exposure to;extracellular;Functional disorder;Heat shock proteins;Human;Immune;Immune response;Immunity;Immunologics;Immunology;immunopathology;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;inflammatory milieu;Inhalation;injured;insight;Knowledge;Laboratories;Link;Lung;Lymphoid Cell;Mediating;Modeling;Molecular;Molecular Biology;Mucous Membrane;Mus;Necrosis;new therapeutic target;novel;Nuclear;Organ;pathogen;Pathogenesis;Pattern;Pattern recognition receptor;Peptide Initiation Factors;pharmacologic;Play;prevent;Prevention strategy;Principal Investigator;Process;promoter;receptor for advanced glycation endproducts;response;Role;Sterility;Testing;Tissues;treatment strategy;TSLP gene;Untranslated Regions;Virus Diseases

PROJECT_TITLE: Allergen-induced extracellular DNA in type 2 immunity

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Endometriosis;Genetics;Human Genome;Pain Research;Prevention;Women's Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative This proposal will advance research relevant to the health of women by expanding the genomic and phenotypic characterization of endometriosis, a disease that affects 10% of women. We will use model systems and advanced `omics technologies to identify the epigenetic regulatory mechanisms that lead to endometriosis. The identification of epigenetic regulatory mechanisms required for endometriosis development will inform new prevention and non-hormonal treatment strategies.

PI_NAMEs: CHANDLER, RONALD L (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Acetylation;Affect;Age;Anoikis;ARID1A gene;ATP Hydrolysis;Biochemical;Biological Availability;Biological Models;Bromodomain;Bromodomains and extra-terminal domain inhibitor;Cell Death;Cells;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;chronic pelvic pain;Complex;Development;Diagnosis;Disease;Endometrial;endometriosis;Enhancers;EP300 gene;epigenetic drug;Epigenetic Process;epigenome;Epithelial Cells;Epithelium;experimental study;Functional disorder;Gene Expression;Genetic;Genetic Transcription;Genome;Genome Mappings;genome-wide;Genomic approach;Genomics;Goals;Greater sac of peritoneum;Growth;Histone Acetylation;histone acetyltransferase;Histone H2A;Histone H4;Histones;hormone therapy;immunoreactivity;in vivo;Infertility;innovation;Invaded;Lesion;Lysine;Mesenchymal;Molecular;mouse model;mutant;Mutation;Nucleosomes;Operative Surgical Procedures;Oral;Outcome;Pain management;Pathway interactions;Patients;Phase I/II Clinical Trial;Phenotype;PIK3CG gene;prevent;Prevention;Prevention strategy;Recurrence;Repression;reproductive;Research;Retrograde Menstruation;Role;Site;Somatic Mutation;Sorting;Technology;theories;Therapeutic;therapeutic target;Tissues;Toxic effect;transcriptome;treatment strategy;Uterus;Variant;Woman;Women's Health;Work

PROJECT_TITLE: Epigenetic regulatory mechanisms and therapeutic opportunities in endometriosis

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Urologic Diseases;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE: Pelvic floor disorders, which include pelvic organ prolapse, and urinary and fecal incontinence, are common and costly conditions that negatively impact the quality of life of millions of women. Childbirth injury and subsequent dysfunction of the pelvic floor muscles are believed to be a major cause of pelvic floor disorders, however preventative and effective therapeutic approaches to counteract these conditions are currently non-existent. The goal of this project is to determine whether a tissue-specific low-cost acellular biomaterial, which can be administered with minimal invasiveness, can treat injured pelvic floor muscles and preserve muscle function.

PI_NAMEs: ALPERIN, MARIANNA  (contact);CHRISTMAN, KAREN L

PROGRAM_OFFICER_NAME: DEYAMPERT, TARA LYNN

PROJECT_TERMS: Abdomen;Atrophic;Basic Science;Biocompatible Materials;Biological Process;Birth trauma;Cell Death;Cell Separation;Cell Therapy;Cells;Cesarean section;Cessation of life;Childbirth;Chronic;Clinical;Collagen;cost;Cues;Development;Economic Burden;Epidemic;epidemiology study;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Extracellular Matrix;Family suidae;Fecal Incontinence;Female;Fibrosis;Functional disorder;Functional impairment;Gene Expression;Gene Expression Profile;Goals;High Prevalence;Histology;Hydrogels;immune cell infiltrate;immunoregulation;improved;In Vitro;in vivo;Injectable;Injections;injured;Injury;injury recovery;innovation;Intervention;Knowledge;Lead;limb injury;Lung;Measures;mechanical properties;minimally invasive;Modeling;modifiable risk;Morbidity - disease rate;Muscle;muscle degeneration;Muscle function;muscle progenitor cell;muscle regeneration;Muscular Atrophy;Natural regeneration;novel;novel therapeutics;Organ;Outcome;parous;Pathologic;Patients;Pelvic Floor Disorders;Pelvic floor dysfunction;Pelvic Floor Muscle;Pelvic floor structure;pelvic organ prolapse;Pelvis;Phenotype;Pilot Projects;Population;Population Dynamics;preempt;Pregnancy;pregnant;preservation;prevent;Prevention;Prevention strategy;Prevention therapy;Preventive measure;Proliferating;Property;protein expression;Public Health;Quality of life;Rattus;Recovery;recruit;regeneration potential;regenerative therapy;Regulation;Rehabilitation therapy;repaired;reparative process;response;Risk;Risk Factors;Role;Saline;scaffold;Signal Pathway;single-cell RNA sequencing;Skeletal Muscle;soft tissue;stem cells;Testing;Therapeutic;therapeutically effective;Time;Tissue Engineering;Tissues;Translational Research;Urinary Incontinence;Woman

PROJECT_TITLE: Prevention of pelvic floor muscle dysfunction with extracellular matrix hydrogel

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(90)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE: Gold-derived compounds modulate mitochondrial function and exhibit efficacious anticancer activity. Combining the unique structural and reactive features of gold compounds with mechanism- of-action studies provide a new platform for the discovery of mitochondria-targeted anticancer agents. This proposal seeks to expand potent gold chemotherapeutic libraries guided by functional biology to elucidate their mode of action and inhibit metastatic tumor in vivo, while sparing normal tissue.

PI_NAMEs: AWUAH, SAMUEL GORMAN (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: 4T1;Adopted;analog;Animals;anti-cancer;anti-tumor agent;anticancer activity;Antineoplastic Agents;antitumor effect;Apoptosis;Autophagocytosis;Biogenesis;Bioinformatics;Biological;Biology;Biometry;Breast Cancer Cell;Cancer Biology;cancer cell;Cancer Model;cell growth;Cessation of life;Chemicals;clinical efficacy;clinical subtypes;comparative;Complex;Data;Development;Disease;drug development;drug discovery;Drug Kinetics;Drug Targeting;effective therapy;Electron Transport;Environment;Exhibits;Fostering;FRAP1 gene;Goals;Gold;Gold Compounds;Growth;Impairment;improved;In Vitro;in vitro Assay;in vivo;Inbred BALB C Mice;innovation;insight;Knowledge;Lead;Libraries;Ligands;Locales;Malignant Breast Neoplasm;Malignant Neoplasms;Maximum Tolerated Dose;Medical;Metabolic;Metastatic Neoplasm to the Liver;Mitochondria;mitochondrial dysfunction;Modeling;Modification;Morphology;mouse model;Mus;nanomolar;Neoplasm Metastasis;new therapeutic target;Normal Cell;Normal tissue morphology;novel;novel strategies;novel therapeutic intervention;Outcome;Oxidative Phosphorylation;Pathway interactions;patient derived xenograft model;Patients;Pharmacodynamics;prevent;Process;Prognostic Marker;programs;Property;Proteins;Proteomics;rational design;Regimen;Research;Respiration;Respiratory Chain;response;scaffold;small molecule;Specificity;Structure;Structure-Activity Relationship;Synthesis Chemistry;targeted agent;targeted treatment;Testing;Therapeutic;Therapeutic Agents;Therapeutic Index;therapeutic target;tool;Toxic effect;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor xenograft;uptake;Work

PROJECT_TITLE: Gold-derived therapeutic compounds for disease application

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Contraception/Reproduction;Endometriosis;Genetics;Pain Research;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PI_NAMEs: NICHOLSON, BRUCE J (contact)

PROJECT_TERMS: Adenoviruses;Adhesions;Adhesives;Affect;Animals;Antibodies;Behavior;CD44 gene;cell behavior;Cell Compartmentation;Cell Separation;Cells;Characteristics;collaborative environment;Connexin 43;Coupling;Dependence;Development;Diagnostic;Disease;Disease Progression;Disseminated Malignant Neoplasm;Down-Regulation;Endometrial;endometriosis;Endometrium;Environment;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Event;Extravasation;Fertility;Fingerprint;Functional disorder;Gap Junctions;Gene Expression;Genes;Genetic Screening;Genomics;Germ Cells;Goals;Harvest;HMMR gene;Hyaluronic Acid;Immunofluorescence Immunologic;Immunohistochemistry;In Vitro;in vitro Model;in vivo;Infection;intercellular communication;Invaded;Lead;Lesion;Mediating;Mesothelium;Modification;Molecular;Mus;mutant;natural Blastocyst Implantation;Neoplasm Metastasis;novel;Pain;Pathogenesis;Pathogenicity;Pathology;Patients;Peritoneal;Peritoneal Mesothelial Cell;Peritoneum;permissiveness;Phenotype;Play;Process;Property;Proteomics;receptor;response;Retrograde Menstruation;Role;Sampling;Scaffolding Protein;Series;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small hairpin RNA;Soil;Stromal Cells;System;Testing;therapeutic target;Tissues;transplant model;Up-Regulation;Woman

PROJECT_TITLE: Molecular mechanisms of gap junction promotion of lesion formation in Endometriosis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Pediatric;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: PROJECT NARRATIVE Despite increasing awareness of post-tuberculosis respiratory morbidity in adults, there is no data in children yet. An estimated 5-10 million children survived tuberculosis between 2000 and 2017 and are at potential risk of lung sequelae. An improved understanding of the impact of tuberculosis and respiratory virus infections on lung health in children could inform strategies to significantly improve the health of young children.

PI_NAMEs: VAN DER ZALM, MARIEKE MARGREET (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: 2 year old;Address;Adenoviruses;Adult;Affect;African;Aftercare;Age;Airway Resistance;aspirate;Awareness;Biological;Biometry;burden of illness;career;career development;Child;Child Health;Childhood;Chronic Disease;Clinical;clinical examination;Clinical Research;clinical translation;clinically relevant;co-infection;cohort;Cohort Studies;Communicable Diseases;Control Groups;critical period;Data;Data Analyses;Data Set;design;Diffusion;Disease;Enrollment;Event;Exclusion;experience;follow-up;functional outcomes;Funding;Future;Goals;Grant;Guidelines;Health;health assessment;Height;high risk;HIV;Hospitalization;improved;Infection;innovation;Institution;interest;International;Intervention;Investigation;Life;Literature;Long-Term Effects;Longitudinal cohort;low and middle-income countries;Lung;lung development;Lung Diseases;lung health;Measures;Mentors;Methods;Microbiology;Modeling;Morbidity - disease rate;Mycobacterium tuberculosis;Nasopharynx;Oscillometry;Outcome;Outcome Measure;pathogen;Physical Examination;Plethysmography;Policies;postnatal;prevent;prospective;pulmonary function;Pulmonary function tests;Pulmonary Tuberculosis;Quality of life;Questionnaires;Radiology Specialty;Recording of previous events;Research;Research Personnel;Research Project Grants;Resistance;respiratory;Respiratory Disease;respiratory health;respiratory infection virus;respiratory morbidity;respiratory pathogen;Respiratory syncytial virus;respiratory virus;Risk;Risk Factors;Sampling;Scientist;Severities;skills;Smoking;South Africa;South African;Spirometry;Techniques;Testing;Thoracic Radiography;Tidal Volume;Time;Training;Translating;translational impact;Tuberculosis;United States National Institutes of Health;Vaccination;ventilation;Viral;viral detection;Viral Respiratory Tract Infection;Vulnerable Populations;Weight

PROJECT_TITLE: The long-term consequences of pulmonary tuberculosis and respiratory viruses on lung health in young South African children

STUDY_SECTION_NAME: International and Cooperative Projects - 1 Study Section[ICP1]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

PHR: PROJECT NARRATIVE In addition to genes, human DNA contains hundreds of thousands of so-called enhancers, which represent switches that turn genes on and off in different cell types and tissues. While enhancers are important for normal human development, it is largely unknown how changes in human enhancer sequences impact on genome function and may contribute to human disease. We propose to use a suite of cutting-edge approaches to generate and examine large panels of enhancers with altered sequences and determine the consequences of these sequence changes for organism function.

PI_NAMEs: PENNACCHIO, LEN ALEXANDER (contact)

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Alleles;Anatomy;base;Benchmarking;Biological Assay;Biological Process;Biology;Calibration;Catalogs;Categories;cell type;Cells;ChIP-seq;clinically actionable;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Communities;Complement;Complex;Coupled;CRISPR screen;Data;Data Set;Dedications;Development;Disease;Distant;DNA;Elements;Engineering;Enhancers;Evolution;experimental study;follow-up;Foundations;Funding;Gene Expression Regulation;Genes;Genetic;Genetic Enhancer Element;Genetic study;Genetic Transcription;genetic variant;Genome;genome sequencing;genomic variation;Genomics;Grant;Human;Human Development;human disease;human DNA;Human Genetics;Human Genome;In Vitro;in vivo;Individual;innovation;insight;Investigation;Joints;Junk DNA;Knock-in;Knock-out;Letters;Link;Maps;Methods;mouse genome;mouse model;Mus;Mutagenesis;Mutate;Mutation;National Human Genome Research Institute;network models;Organism;Patients;Pattern;Phase;Phenotype;Positioning Attribute;postnatal development;predictive modeling;prenatal;Process;programs;prototype;Publications;Regulatory Element;Reporter;Reporter Genes;Research;Research Personnel;Resources;Role;Specificity;Testing;Tissues;tool;Transgenic Mice;Transgenic Organisms;Untranslated RNA;Validation;Variant;whole genome;Work

PROJECT_TITLE: Functionally Assessing Transcriptional Enhancers In Vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(02)M]