ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Immunization;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Vaccine Related

ORG_CITY: HUNTINGTON BEACH

ORG_NAME: INSTITUTE FOR MOLECULAR MEDICINE

PHR: Project Narrative LBD, also known as Alzheimer's Disease Related Disorder (ADRD), is the second most common cause of dementia after AD affecting approximately 1.4 million Americans, with no FDA-approved medications to treat LBD and few medications in clinical trials, leaving a great unmet need for patients and their families. Recently we developed the PV-1950R/A vaccine based on a MultiTEP platform technology that is highly immunogenic in mice, rabbits, and monkeys and demonstrated the efficacy in the αSyn D line mouse model of LBD. In this U01 project, we propose to manufacture the cGMP adjuvanted vaccine, PV-1950R/A, complete IND-enabling safety/toxicology studies in LBD mouse model and non-human primates, submit and obtain all of the necessary regulatory documents for an FDA-approved investigational new drug (IND) and conduct pilot phase 1 trial in healthy individuals (Phase 1a) and individuals with patients with rapid eye movement sleep behavior disorder (RBD) who are at the risk of LBD (Phase 1b).

PI_NAMEs: AGADJANYAN, MICHAEL G (contact);GALVIN, JAMES E

PROGRAM_OFFICER_NAME: REFOLO, LORENZO

PROJECT_TERMS: Acute;Adjuvant;Affect;Age;Age of Onset;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;American;Amyloid;Amyloid beta-Protein;Animals;Antibodies;Antibody titer measurement;B-Lymphocyte Epitopes;Behavior Disorders;Biological Assay;Brain;Brain Stem;Caregiver Burden;cell bank;Cells;Chronic;Clinical;Clinical Trials;Cognitive;Complex;cost;Country;Cyclic GMP;Data;Dementia;Dementia with Lewy Bodies;Development;Diagnosis;disability burden;Disease;Dose;Double-Blind Method;Encephalitis;Endopeptidase K;Engineering;enzyme linked immunospot assay;Epitopes;extracellular;Family;FDA approved;first-in-human;functional disability;Future;Goals;healthy volunteer;Helper-Inducer T-Lymphocyte;high risk;Human;human study;immunogenic;immunogenicity;Immunotherapy;Individual;innovation;interest;Investigational Drugs;Lewy Bodies;Lewy Body Dementia;Lewy neurites;liver function;manufacture;Measures;Metabolic;Monkeys;mouse model;Movement Disorders;Mus;Neocortex;Nerve Degeneration;Neurodegenerative Disorders;neuronal cell body;Neurons;nonhuman primate;Onset of illness;Oryctolagus cuniculus;Parkinson's Dementia;Participant;Pathologic;Pathology;Patients;Peripheral;Persons;Pharmaceutical Preparations;Phase;phase 2 study;Phase I Clinical Trials;phase I trial;Phase Ia Trial;Phosphorylation;Placebo Control;Plasmids;pre-clinical;Preparation;presynaptic;prevent;Preventive vaccine;Primary Prevention;Process;Proteins;public health relevance;Randomized;Recombinant Proteins;REM Sleep Behavior Disorder;Renal function;Research;Resistance;response;Risk;Running;Safety;safety study;safety testing;Scientist;Site;skin biopsy;Structure;Synapses;tau Proteins;Technology;technology platform;Testing;Therapeutic;Thyroid Function Tests;Toxic effect;Toxicology;United States;Vaccination;vaccine formulation;vaccine trial;Vaccines;Vial device;volunteer

PROJECT_TITLE: IND enabling CMC/safety/toxicology studies, submission of IND and pilot Phase 1 clinical trial with PV-1950R vaccine for Lewy Body Dementia (LBD)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-J (O1)]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Neurofibromatosis;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE This application focuses on using genetically engineered mouse models and cell culture models of neurofibromatosis type 2 to characterize the role of focal adhesion kinase (FAK) signaling in the development of NF2-related schwannomas. These complementary in vitro and in vivo studies will determine the genetic contribution of FAK1/PTK2 in schwannoma development, the potential utility of post-IND FAK inhibitors, alone or in combination with other phase I/II or FDA approved kinase inhibitors, and molecular response signatures to treatment. Collectively, the genetic, pharmacologic, and genomic approaches will enable rapid translation to early phase clinical trials for NF2 schwannoma patients who currently lack effective targeted therapy options.

PI_NAMEs: ANGUS, STEVEN P;CLAPP, DAVID W (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Ablation;Acoustic Neuroma;Affect;Affinity Chromatography;Alleles;anaplastic lymphoma kinase;autosome;Benign;Bilateral;bilateral vestibular Schwannoma;Biochemical;Brain Stem;Bromodomains and extra-terminal domain inhibitor;cancer predisposition;Cell Culture Techniques;Cells;Cessation of life;Characteristics;chemotherapy;chronic neuropathic pain;chronic pain;Clinic;Clinical Research;Clinical Trials;combinatorial;CRISPR screen;CRISPR/Cas technology;crizotinib;Data;deafness;Dependence;Development;Drug Combinations;Drug Synergism;Drug Targeting;early phase clinical trial;effective therapy;Evaluation;Excision;Exhibits;experimental study;Facial Muscles;FDA approved;Focal Adhesion Kinase 1;Generations;Genetic;Genetically Engineered Mouse;Genomic approach;Germ Lines;Goals;Growth;hearing impairment;Histology;Human;improved;In Vitro;in vivo;Incidence;Individual;inhibitor;innovation;insight;Investigational Therapies;kinase inhibitor;Kinetics;Knock-out;Laboratories;Link;Logistics;Loss of Heterozygosity;LoxP-flanked allele;Malignant Neoplasms;MAP Kinase Gene;Mass Spectrum Analysis;Mediating;MEKs;Modeling;Molecular;Morbidity - disease rate;Motor;Mus;Muscle Weakness;Mutation;Nervous System Disorder;Neurilemmoma;Neurofibromatosis 2;Neurofibromin 2;Neurologic;next generation;novel strategies;novel therapeutics;Operative Surgical Procedures;Pathologic;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase;Phase I/II Clinical Trial;Phosphotransferases;pre-clinical;preclinical efficacy;preclinical study;precursor cell;Predisposition;progressive hearing loss;Proteins;PTK2 gene;rare cancer;Rare Diseases;Receptor Protein-Tyrosine Kinases;Research Personnel;Resistance;response;Role;Schwann Cells;screening;Signal Transduction;single-cell RNA sequencing;small molecule;Spinal;success;Syndrome;synergism;targeted treatment;Testing;Therapeutic;Toxic effect;transcriptome;translational potential;Translations;tumor;tumor growth;tumor progression;Tumor Suppressor Genes;Tumor Tissue;tumorigenesis;tumorigenic;Tyrosine Kinase Inhibitor;Vertigo;vestibular system;Work

PROJECT_TITLE: Identification of novel therapeutic combinations for NF2 schwannomas

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Newark

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Narrative Our preliminary data indicate that inhibition and deletion of STIM2 attenuates acute and chronic itch behavior in mice. Blockage, deletion of STIM2 almost eliminates GRP-induced calcium entry in dorsal horn neurons and LPS-induced cytokine production in astrocytes. Successful completion of this project will not only identify STIM2 as a novel key modulator of itch sensation, but will also decipher the molecular mechanisms underlying chronic itch.

PI_NAMEs: HU, HUIJUAN  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Ablation;Acute;Aftercare;antagonist;Antibodies;Astrocytes;Attenuated;Behavior;Calcium;Calcium Channel;cell type;Chloroquine;chronic itch;Clinical;conditional knockout;Couples;cytokine;Cytomegalovirus;Data;Dinitrobenzenes;Dinitrofluorobenzene;dorsal horn;Dryness;Endoplasmic Reticulum;excitatory neuron;Family member;Fluorescein-5-isothiocyanate;Genetic;Glial Fibrillary Acidic Protein;GRP gene;hindbrain;Histamine;insight;Interleukin-1 beta;Interleukin-6;knock-down;Knock-out;Knockout Mice;LCN2 gene;Measures;Mediating;Mediator;Messenger RNA;Microinjections;Molecular;mouse model;Mus;neuronal excitability;Neurons;Nociception;novel;overexpression;Pain;Pathway interactions;Pattern;Play;Posterior Horn Cells;Production;Proteins;Pruritus;Research;response;Role;sensor;Signal Pathway;Signal Transduction;Skin;Slice;Spinal;Spinal Cord;Stains;Stat3 protein;STIM1 gene;Testing;Time;TLR4 gene;TNF gene;Touch sensation;transmission process;vesicular glutamate transporter 2;Western Blotting;Work

PROJECT_TITLE: Role of stromal interaction molecule 2 in chronic itch

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

ORG_CITY: Aurora

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE  This study will use a cross-sectional design and mixed-methods to examine mental health among recently arrived Latinx immigrant adults through the development of mental health phenotypes shaped by the intersection of trauma exposure, symptom severity (of depression, anxiety and PTSD), and individual characteristics. Extreme violence has been a main contributor to migration to the U.S. from Latin America. This K01 Award proposes to develop mental health phenotypes in this population in order to develop longitudinal studies on the evolving mental health of immigrants and inform the development and delivery of appropriate interventions for the right person at the right time.

PI_NAMEs: VARGAS, LAURA X (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Adult;Age;Anxiety;Attention;base;bilingualism;career;career development;Characteristics;Cohort Studies;Collaborations;Country;Crime;Cultural Backgrounds;Data;demographics;deprivation;design;Development;Development Plans;Discrimination;Education;Equation;Ethics;Ethnic Origin;Evolution;experience;Exposure to;Family;Foundations;Future;Gender;gender difference;Goals;Grant;Growth;Health;health disparity;health service use;high risk;Homicide;Human;Immigrant;improved;Individual;innovation;Intervention;intervention delivery;Intervention Studies;Interview;Latin America;Latinx;Lead;Longitudinal Studies;Marital Status;Measures;Mediating;Mental Depression;mental development;Mental Health;Mental Health Services;Mentored Research Scientist Development Award;Mentors;Methods;Mexico;Migrant;migration;Modeling;National Institute on Minority Health and Health Disparities;Natural History;Outcome;Participant;perceived discrimination;Persons;Phenotype;Policies;Population;Population Policies;Positioning Attribute;Post-Traumatic Stress Disorders;Poverty;programs;prospective;Prospective Studies;Public Health;Qualitative Methods;recruit;Research;Research Design;Research Methodology;Research Personnel;Sampling;Severities;sex;sexual exploitation;Shapes;Site;Solid;Subgroup;Surveys;Symptoms;Testing;therapy development;Time;tool;Training;Translational Research;Trauma;trauma exposure;traumatic event;Travel;Variant;Violence;violence exposure;Vulnerable Populations

PROJECT_TITLE: Mental health phenotypes shaped by trauma exposure, symptom severity, and individual characteristics among recent Latinx immigrant adults


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Neurosciences;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

ORG_STATE: MD

PHR: WHO Grade II and Grade III astrocytomas are common gliomas occurring in early middle adult life. Almost all progress to higher grade including secondary GBM. Grade II/III astrocytomas are distinguished from other gliomas by their typical mutational background consisting of IDHmut/p53mut/ATRXloss and are understudied relative to glioblastoma. Immunotherapy offers great promise in other cancers but has not yet been effective against brain tumors including astrocytoma. This research will use pre-clinical models to identify immunosuppressive transcriptional mechanisms of astrocytoma and amplified by standard-of-care radiation therapy. Positive results will develop a novel combinational immunotherapy strategy for IDHmut/p53mut/ATRXloss Grade II/III astrocytoma.

PI_NAMEs: LI, YUNQING  (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: 3-Dimensional;Adult;anti-cancer;anti-CTLA-4 therapy;anti-CTLA4;anti-tumor immune response;Antigen Presentation Pathway;Astrocytoma;ATRX gene;Autologous;Brain Neoplasms;Bromodomain;cancer infiltrating T cells;Cells;Cerebrum;chemokine;chemoradiation;Chemotherapy and/or radiation;Combination immunotherapy;Critical Pathways;cytokine;Data;DNA Methylation;Down-Regulation;Epigenetic Process;Event;Excision;experimental study;Family member;Gene Expression Profile;Genes;Genetic Transcription;genome-wide;Glioblastoma;Glioma;Goals;histone methylation;humanized mouse;Immune;Immune Evasion;Immunocompetent;immunoregulation;immunosuppressive checkpoint;Immunotherapeutic agent;Immunotherapy;Interferon Type II;Interferons;Ionizing radiation;Isocitrate Dehydrogenase;Knowledge;Life;Ligands;Macrophage;Malignant Neoplasms;Mediating;Methylation;Modeling;Molecular;Mus;Mutation;neoplasm immunotherapy;neoplastic cell;Neurosphere;next generation;novel;novel strategies;Oncogenic;Operative Surgical Procedures;Organoids;Pathway interactions;Patients;Play;pre-clinical;Pre-Clinical Model;Probability;programs;Publishing;Radiation;Radiation therapy;Research;response;Role;Signal Transduction;standard of care;T-Lymphocyte;temozolomide;Testing;therapeutically effective;TP53 gene;transcriptome;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Xenograft procedure;young adult

PROJECT_TITLE: Targeting oncogenic epigenetic mechanisms in IDHmut/ATRXloss Astrocytoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCTC-S (01)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

ORG_STATE: PA

PHR: PROJECT NARRATIVE The loss of endogenous tumor suppression is an obligatory step towards cancer, but the mechanisms are elusive. We have now discovered that Parkin, a molecule altered in early-onset Parkinson’s disease, functions as a unique dual mode tumor suppressor, inhibiting intrinsic tumor traits of cell motility and metabolism while also reprogramming an antitumor immune microenvironment. This pathway involves Parkin “priming” of immunogenic cell death, control of cytosolic and mitochondrial danger-sensing pathways and transcriptional activation of interferon gene expression. The proposed studies will elucidate the cellular and molecular requirements of Parkin innate immunity in cancer and uncover novel strategies to improve the response to immunotherapy in advanced disease patients.

PI_NAMEs: ALTIERI, DARIO C (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: advanced disease;Antitumor Response;Area;Autophagocytosis;Biochemical;biological adaptation to stress;cancer vaccination;CD8-Positive T-Lymphocytes;Cell Death;cell motility;Cell Physiology;Cellular Metabolic Process;Clinic;Collaborations;Complex;Consensus;conventional therapy;cytokine;Data;Dedications;Dendritic Cells;Disease;Disease Progression;early onset;endoplasmic reticulum stress;energy efficiency;Epigenetic Process;Equilibrium;extracellular;Feedback;Gene Expression;Genes;genetic makeup;Genetic Transcription;Human;Immune;immunogenic cell death;Immunosuppression;Immunotherapy;improved;in vivo;Infiltration;Inflammasome;Inflammatory;Interferon Activation;Interferons;International;Investigation;Laboratories;Letters;Malignant Neoplasms;Maps;Metabolism;Mitochondria;Molecular;mouse model;multidisciplinary;Multiprotein Complexes;Myelogenous;Natural Immunity;Neoplasm Metastasis;novel;novel strategies;Organelles;Oxidation-Reduction;Parkin;Parkinson Disease;Pathway interactions;patient response;Patients;Pattern;Pentosephosphate Pathway;Phosphotransferases;pre-clinical;Primary Neoplasm;Production;programs;protein complex;recruit;Regulation;response;Role;Science;Signal Transduction;Sorting;STAT1 gene;Stimulator of Interferon Genes;stress management;T-Cell Activation;Testing;therapeutic target;Tissues;trafficking;trait;Transcriptional Activation;Transgenic Mice;Transgenic Model;tumor;tumor growth;tumor immunology;Tumor Suppression;Tumor Suppressor Proteins;tumor-immune system interactions;Ubiquitin;ubiquitin-protein ligase;vaccination strategy;Virus;Virus Diseases

PROJECT_TITLE: Parkin tumor suppression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Q (80)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Kidney Disease;Rare Diseases;Sickle Cell Disease

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Epidemiologic studies have demonstrated that sickle cell trait (SCT) is associated with both venous thrombosis and chronic renal injury. We propose that unique biophysical conditions within venous clots and within the inner renal medulla promote sickling in sickle trait erythrocytes that can result in an increased tendency to blood clotting and kidney dysfunction. Our project will examine this hypothesis in human samples and a mouse model in order to identify the best therapeutic approach to attenuate these complications.

PI_NAMEs: KEY, NIGEL S. (contact);PAWLINSKI, RAFAL L

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Acidosis;Adhesions;Adhesiveness;Adhesives;adverse outcome;age related;Alabama;Albuminuria;American;Attenuated;Back;Benign;beta Globin;Biological Assay;biophysical model;Biophysics;Blood;Blood coagulation;Blood specimen;Blood Vessels;Blood Viscosity;Cell membrane;Chronic;Chronic Kidney Failure;Clinical;Coagulation Process;Control Animal;Data;Disease;early onset;Environment;epidemiology study;Erythrocytes;Exposure to;Factor XII;Generations;Genes;Glomerular Filtration Rate;Hematology;Hemoglobin A;hemoglobin polymer;Hemoglobinopathies;Hemolysis;Heterozygote;High Prevalence;Human;human subject;Hypoxia;Impairment;Individual;Injury to Kidney;insight;Kidney;kidney dysfunction;kidney medulla;Laboratories;Laminin;Life Expectancy;Mediating;Membrane;mouse model;Mus;Mutation;novel;Nucleotides;P-Selectin;Persons;Phenotype;polymerization;Polymers;Population Attributable Risks;prevent;Principal Investigator;programs;Public Health;recruit;Relative Risks;Research;Reticulocytosis;Risk;Role;Sampling;Sickle Cell;Sickle Cell Anemia;Sickle Cell Trait;Sickle Hemoglobin;sickling;Stress;Study models;Sulfoglycosphingolipids;Surface;systemic inflammatory response;Testing;Therapeutic;Thrombin;Thromboplastin;thrombotic;Thrombus;trait;Universities;Vas Occlusions;Venous;Venous Thrombosis;Whole Blood

PROJECT_TITLE: Mechanisms of venous thrombosis and renal dysfunction in sickle trait

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Macular Degeneration;Nanotechnology;Neurodegenerative;Neurosciences

ORG_CITY: IOWA CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: RELEVANCE STATEMENT Age-related macular degeneration (AMD) is the leading cause of blindness in the United States. We are developing a sustained drug delivery system to target two components of wet AMD that cause irreversible blindness, the growth of new blood vessels and fibrosis. By targeting both phenomena with a long-term delivery system, we may be able to reduce progression of the disease and protect vision.

PI_NAMEs: MULLINS, ROBERT FOSTER;TUCKER, BUDD A (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Address;Age related macular degeneration;Animal Model;Animals;arm;Automobile Driving;bevacizumab;Biodistribution;Blindness;Blood Vessels;Cicatrix;Clinic;Clinical;Combined Modality Therapy;comparison control;Data;Disease;Disease Progression;Dose;Drug Delivery Systems;Edema;effective therapy;Exhibits;Exudate;Exudative age-related macular degeneration;Eye;FDA approved;Fibrosis;Fluorescein Angiography;Follow-Up Studies;healthcare burden;Hemorrhage;HIF1A gene;Immunohistochemistry;Individual;inhibitor;Injections;Legal patent;Liquid substance;Longterm Follow-up;Modeling;nanocapsule;Nature;neovascularization;Nerve Degeneration;new growth;Outcome;Patient Compliance;Patients;Pharmaceutical Preparations;Pirfenidone;Polyurethanes;preservation;prevent;programs;Quality of life;Rattus;Reading;Recovery;Research;Retina;Retinal Edemas;Risk;Route;Saline;Structure;System;systemic toxicity;Testing;Time;Tissues;Toxic effect;Translating;ultrasound;United States;Vascular Endothelial Growth Factors;Vegf inhibition;Vision;Visual Acuity;Work

PROJECT_TITLE: Sustained Treatment of wet AMD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE This proposal is about the human brain and how it makes impressions of other people’s social attributes such as age, gender, trustworthiness, competence, etc., immediately after viewing their face. It is also about how these impressions change by the social contextual information. The cognitive functions probed in our proposal have a pervasive influence on many aspects of our social interactions with and is at the core of dysfunction in several psychiatric disorders such as autism.

PI_NAMEs: ADOLPHS, RALPH ;PARVIZI, JOSEF  (contact);RUTISHAUSER, UELI

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Affect;Age;Amygdaloid structure;analytical tool;Anatomy;Area;autism spectrum disorder;base;Behavior;behavior prediction;Behavioral;Binding;Biography;Brain;Brain region;Categories;Cells;Code;cognitive function;Competence;Computer Models;Coupling;Cues;Data;design;Dimensions;Disease;Electric Stimulation;Electrophysiology (science);Etiology;Evoked Potentials;experimental study;Face;Face Processing;Frequencies;frontal lobe;Functional disorder;Functional Magnetic Resonance Imaging;Gender;Geometry;Goals;Grain;Health;Hippocampus;Human;Image;impression;Individual;information processing;innovation;interest;Investigation;Judgment;Knowledge;Link;Machine Learning;Maps;Measures;Medial;medial temporal lobe;Memory;Mental disorders;millisecond;Modeling;multimodality;neural;neuromechanism;Neurons;novel;Participant;Patients;Persons;Phase;Physiologic pulse;Play;Population;predictive modeling;psychologic;racial diversity;response;Rest;Role;Sampling;Semantics;Sensory;Shapes;Signal Transduction;Site;social;Social Behavior;Social Change;Social Environment;Social Interaction;Stimulus;Structure;Temporal Lobe;temporal measurement;Testing;Time;tool;trait;trustworthiness;Visual;Work

PROJECT_TITLE: Neural Mechanisms of Social Attribution from Faces

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Nutrition;Obesity;Patient Safety;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: While several medical and surgical weight reduction strategies are available, with newer, transformative medications recently approved, little is known about their safety and effectiveness in clinical practice. This proposal’s goal is to develop, implement, and test approaches to produce large scale, high-quality evidence on the comparative safety and effectiveness of medical and surgical weight loss strategies in clinical practice. This work will develop more accurate, methodologically rigorous approaches to conduct real-world evidence studies of medical and surgical weight reduction strategies using large scale, real-world data and will create an invaluable infrastructure to conduct future studies on the comparative safety and effectiveness of various cardiometabolic treatments.

PI_NAMEs: PATORNO, ELISABETTA  (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Address;Adult;Adverse event;Affect;Agonist;Algorithms;bariatric surgery;Body mass index;Body measure procedure;Body Weight decreased;Bupropion;Calibration;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;Categories;Cessation of life;Clinical;Clinical Management;clinical practice;comparative effectiveness;Comparative Effectiveness Research;comparative safety;Complement;Data;data infrastructure;Databases;dietary;Dietary Practices;Effectiveness;Epidemiology;Event;Follow-Up Studies;Future;Gastric Bypass;GLP-I receptor;glucagon-like peptide 1;Goals;Head;Health Insurance;Health Professional;improved;Infrastructure;insight;insurance claims;Knowledge;Life Style;Link;Long-Term Effects;Longitudinal cohort study;machine learning prediction;Malignant Neoplasms;Measurement;Measures;Medical;Medical Research;men;Methodology;Modification;Naltrexone;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Nurses' Health Study;obese patients;Obesity;Obesity Epidemic;Operative Surgical Procedures;Outcome;Outcome Measure;Participant;Patient Representative;Patients;Pharmaceutical Preparations;Pharmacoepidemiology;Phentermine;prediction algorithm;premature;Production;Randomized, Controlled Trials;Residual state;Risk;Safety;Specificity;Standardization;Statistical Methods;study population;success;Testing;topiramate;Validation;waist circumference;weight loss intervention;Woman;Work

PROJECT_TITLE: Novel approaches to improve comparative effectiveness research of medical and surgical weight reduction strategies in clinical practice

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-F (90)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Kidney Disease;Prevention

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Vascular calcification is prevalent in patients with chronic kidney disease and contributes to mortality. This research proposal will investigate a new and promising therapeutic target for the treatment of vascular calcification. The results will have important implications for the development of future interventions to reduce the burden of vascular calcification in this high- risk population.

PI_NAMEs: CHEN, WEI  (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Affect;Aorta;Arterial Fatty Streak;Arterial Medias;Attenuated;Blood;Blood Vessels;bone health;Breast Microcalcification;calcification;calcification inhibitor;calcium phosphate;cardiovascular risk factor;Cattle;Cell Communication;Cell Physiology;Cells;Chronic Kidney Failure;Chronic Kidney Insufficiency;Coculture Techniques;cohort;Coronary artery;coronary artery calcification;Development;Early Diagnosis;Early Intervention;effective therapy;Endothelial Cells;endothelial dysfunction;Endothelium;Exposure to;follow-up;Future;Hemostatic function;high risk population;Human;In Vitro;Inflammation;insight;Intervention;Knowledge;Lead;longitudinal, prospective study;Measures;Mediating;Methods;mineralization;mortality;nanoparticle;Nitric Oxide;novel;Osteogenesis;osteogenic;paracrine;particle;Particle Size;Pathogenicity;Patient Recruitments;Patients;Physiologic calcification;Play;Positron-Emission Tomography;preclinical study;Predisposition;prevent;Process;Production;prospective;Proteomics;Research Proposals;response;Role;Sampling;Serum;Serum Markers;Smooth Muscle Myocytes;Sodium Fluoride;study population;System;Testing;therapeutic target;Time;translational potential;uptake;Vascular calcification;Vascular Smooth Muscle;X-Ray Computed Tomography

PROJECT_TITLE: Calciprotein Particles and Vascular Calcification in Patients with Chronic Kidney Disease

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences;Nutrition;Precision Medicine;Prevention

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Alzheimer's disease is a fatal neurodegenerative disease. Modified Mediterranean-Ketogenic Diet (MMKD) has shown promising efficacy against Alzheimer's disease. Our primary goal in this project is to characterize brain cells-derived extracellular vesicles in plasma as `liquid biopsies' to understand the effect of MMKD on molecular circuitries in the aMCI brain and to predict the intervention response.

PI_NAMEs: CRAFT, SUZANNE ;DEEP, GAGAN  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Acetoacetates;Adult;Advanced Glycosylation End Products;Adverse effects;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;American Heart Association;amnestic mild cognitive impairment;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Ancillary Study;Apolipoprotein E;Astrocytes;Autopsy;beta-Hydroxybutyrate;Biochemical;Biological Markers;blood-based biomarker;Brain;brain cell;brain dysfunction;Brain imaging;brain tissue;cell type;Cerebrovascular Circulation;Circulation;Clinical;clinical application;Cognitive;cognitive testing;Communication;Data;Data Correlations;Deposition;diagnostic biomarker;Diet;Dietary Intervention;Disease Progression;efficacy evaluation;Endothelium;evidence base;exosome;extracellular vesicles;Failure;Fatty acid glycerol esters;Genotype;glucose metabolism;Glutamate Receptor;Glutamate Transporter;glutamatergic signaling;Glutamates;Glutamine;glycosylation;Goals;Human;improved;Individual;Inflammation;Inflammatory;Intake;Intervention;Journals;ketogenic diet;Ketones;liquid biopsy;Magnetic Resonance Imaging;Mass Spectrum Analysis;Measures;Metabolic;MicroRNAs;mild cognitive impairment;Molecular;molecular diagnostics;monocyte;Neurodegenerative Disorders;neuroimaging;neuroinflammation;Neurons;NMDA receptor A1;nutrition;Oligodendroglia;Outcome;Oxidative Stress;Participant;Pathogenesis;Pathway interactions;Pericytes;Peripheral;personalized approach;phase 2 study;Pilot Projects;Plasma;Play;Positron-Emission Tomography;precision medicine;predicting response;prevent;preventive intervention;Prognostic Marker;Proteins;Publishing;receptor for advanced glycation endproducts;Reporting;responders and non-responders;response;Role;Sampling;saturated fat;screening;Signal Transduction;Solid;standard measure;Structure;success;Surface;Synaptic plasticity;tau Proteins;tau-1;Testing;therapeutic target;tool;uptake

PROJECT_TITLE: Liquid biopsies to evaluate the effect of a ketogenic diet on molecular circuitries associated with mild cognitive impairment

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Public health relevance Autoimmune diseases and current treatments of these diseases burden their patients with high medical costs and poor quality of life. The project responds directly to the need to develop an efficacious therapy for these patients that does not cause long-term immune deficiency. The completion of this project is expected to establish a new therapeutic strategy that meets this need.

PI_NAMEs: CHEN, MINGNAN  (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Acute;adaptive immune response;adaptive immunity;Address;Affect;Albumins;American;Animals;anti-PD-1;Antibodies;Area;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;autoreactivity;B-Lymphocytes;Binding;Biological Markers;burden of illness;cell killing;Cells;Chronic;Clinical;clinically relevant;Data;design;disease model;Drug Kinetics;Effector Cell;effector T cell;efficacious treatment;Elements;Engineering;Exotoxins;Experimental Autoimmune Encephalomyelitis;Failure;Fc Receptor;Future;Goals;Hand;Human;Immune;Immune response;Immunity;immunodeficiency;immunogenicity;improved;in vivo;Infection;Infiltration;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Investigation;Kinetics;Leukocytes;Link;Lymphocyte;Lymphocyte Suppression;lymphoid organ;Maximum Tolerated Dose;Medical Care Costs;Methods;Modeling;Multiple Sclerosis;Mus;National Institute of Allergy and Infectious Disease;novel;novel therapeutic intervention;Opportunistic Infections;Organ;Patients;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Plasma;Population;Predisposition;preservation;prevent;Prevention;programmed cell death protein 1;Protein Binding Domain;Proteins;Pseudomonas;Pseudomonas aeruginosa toxA protein;public health relevance;Quality of life;receptor;Regimen;Relapse;Safety;systemic autoimmune disease;Systemic Lupus Erythematosus;T-Lymphocyte;Testing;Therapeutic;Time;Tissues;tool;Toxic effect;Translating;treatment strategy;Vaccines;White Blood Cell Count procedure

PROJECT_TITLE: Targeted depletion of programmed death-1 positive cells, a method that not only stops autoimmune attack but also preserves adaptive immunity

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative The necrotic tumor microenvironment could significantly modulate glioblastoma development and therapeutics. The proposed study will focus on understanding the mechanism and function of necrosis during glioblastoma malignant progression and exploring specific vulnerabilities in this process for therapeutic purposes. Results from this study may provide a new horizon to explore the necrotic tumor microenvironment as a diagnostic marker or therapeutic target in glioblastoma.

PI_NAMEs: LI, WEI  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Allografting;Anatomy;Area;Automobile Driving;Biological Process;Cell Death;cell killing;Cell Line;Cells;Classification;Clinical;Coenzyme A Ligases;cytokine;Cytoplasmic Granules;Development;Diagnostic;diagnostic biomarker;experience;experimental study;Extensive Necrosis;Family member;Gene Expression;Genes;genetic approach;genetic signature;Genetic Transcription;Glioblastoma;Glioma;glutathione peroxidase;Goals;Human;Hypoxia;In Vitro;in vivo;Iron;Lipid Peroxides;Malignant - descriptor;Malignant Neoplasms;Mediating;Mesenchymal;Mesenchymal Differentiation;Modeling;molecular pathology;mouse model;Mus;Nature;Necrosis;Necrosis Induction;neoplastic cell;nerve stem cell;neutrophil;Neutrophil Infiltration;novel;Outcome;Pathologic;Pathway interactions;Patients;Peroxidases;pharmacologic;Primary Brain Neoplasms;Process;Prognosis;programs;Reduced Glutathione;Reporting;Role;Sampling;Survival Rate;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Thrombosis;Transcriptional Coactivator with PDZ-Binding Motif;transcriptome;treatment response;tumor;tumor hypoxia;tumor microenvironment;tumor progression;Tumor Promotion;Xenograft Model

PROJECT_TITLE: The role and mechanism of necrosis in glioblastoma

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Allergic Rhinitis (Hay Fever);Asthma;Biotechnology;Food Allergies;Genetics;Health Effects of Indoor Air Pollution;Lung;Prevention

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: RELEVANCE (See instructions):  Patients with asthma and allergic diseases have persistent respiratory health problems and exaggerated  immune responses to common inhaled allergens. This project will investigate how exposure to natural  allergens causes, prolongs, and intensifies these diseases.

PI_NAMEs: KITA, HIROHITO  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Acute;airborne allergen;Allergens;Allergic;allergic airway inflammation;Allergic Disease;Allergic inflammation;Allergy to peanuts;Alternaria;Anaphylaxis;Antibodies;Antibody Formation;Asthma;Atopic Dermatitis;Autoimmunity;Award;B-Lymphocytes;beta-Galactosidase;Biological;Biological Testing;Blocking Antibodies;cell type;Cells;clinical phenotype;Collaborations;cytokine;Cytometry;Data;Development;Disease;Enzymes;Eosinophilia;eosinophilic inflammation;Exposure to;Extrinsic asthma;Flour;Flow Cytometry;Food Hypersensitivity;Functional disorder;functional genomics;Funding;fungus;Galactosidase;Generations;Genetic;genetic approach;Genomic approach;Grant;Hay fever;Helper-Inducer T-Lymphocyte;Human;IgE;Immune;Immune response;Immunity;Immunoglobulin Class Switching;Immunoglobulin G;Immunologics;In Vitro;in vivo;Infection;Inflammation;Inhalation;innate immune mechanisms;Instruction;Interleukin-13;interleukin-21;Interleukin-4;Interleukin-5;Kale - dietary;Laboratories;Lung;Maintenance;Manuscripts;Mediating;Memory;microbial;Modeling;mouse genetics;mouse model;Mucous Membrane;Mus;Nasal Polyps;novel;novel therapeutic intervention;Outcome;Parabiosis;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;pharmacologic;Play;Pollen;prevent;Production;Productivity;programmed cell death protein 1;Progress Reports;Pulmonary Pathology;Pyroglyphidae;receptor;Regulation;Regulatory T-Lymphocyte;Reporter;Research;respiratory health;Respiratory Mucosa;response;Role;secondary lymphoid organ;Structure of germinal center of lymph node;Structure of parenchyma of lung;Syndrome;T-Lymphocyte Subsets;Testing;Time;tissue culture;Tissues;TNFSF5 gene;transcription factor;transcriptome sequencing;Transgenic Mice;wasting

PROJECT_TITLE: Mechanisms of Allergen-induced Type 2 Immunity

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Rare Diseases

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Relevance to Public Health: Keratoconus is a major cause of visual loss in young adults and the leading indication for corneal transplantation in the United States. Identifying keratoconus at an early stage is vital to be able to deliver treatments to patients when they are maximally effective and prevent corneal transplantation. The goal of this project is to develop new technology that will ultimately enable clinicians to identify and treat keratoconus at an early stage.

PI_NAMEs: ABOU SHOUSHA, MOHAMED FADEL;RUGGERI, MARCO  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TITLE: Wide-field corneal microlayer tomography for keratoconus


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: MADISON

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE Alzheimer's disease is correlated with vascular disease; however, the nature and mechanism by which these diseases interact to develop clinical dementia remains relatively unknown. The novel MRI techniques in this project enable new insights into vascular health. The overarching objective is to enable characterization of cerebrovascular involvement in Alzheimer's Disease pathology through the development and study integration of a new battery of non-invasive cerebrovascular health measures including tools to image vascular stiffness and flow oscillations.

PI_NAMEs: JOHNSON, KEVIN MICHAEL (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: 4D MRI;Abeta clearance;Acceleration;Address;Adoption;Affect;alternative treatment;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Animal Model;arterial spin labeling;arterial stiffness;Attention;attenuation;Biological Markers;Blood capillaries;Blood flow;Blood Vessels;Caliber;capillary bed;Cardiac;Cardiovascular Diseases;Cause of Death;Cephalic;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular health;Clinical;clinical translation;Clinical Trials;Cognition;cohort;Cohort Studies;Complex;curative treatments;Data;deep learning;Dementia;dementia risk;Development;Disease;Disease Marker;Early identification;elastography;endothelial dysfunction;FarGo;Frequencies;Functional disorder;Generations;Goals;Health;Hemodynamic Phenomena;hemodynamics;Heterogeneity;high risk;Homeostasis;Human;human subject;hypoperfusion;Image;imaging biomarker;Impaired cognition;improved;individual patient;innovation;insight;Institution;Knowledge;Link;Liquid substance;Longitudinal cohort study;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;Methodology;Methods;mild cognitive impairment;Modeling;Motion;National Institute of Neurological Disorders and Stroke;Nature;Nerve Degeneration;Nervous System Disorder;neuroimaging;neuroinflammation;neuropathology;neurovascular;Noise;non-invasive imaging;novel;novel strategies;optical imaging;Participant;Pathology;Patients;Perfusion;Physiologic pulse;Population;Population Study;Positioning Attribute;Predisposition;premature;Prevalence;progression marker;protective factors;Protocols documentation;recruit;Regulation;Research;Resolution;Rest;Risk;Risk Factors;Role;Sampling;Sensitivity and Specificity;Specificity;Symptoms;Techniques;Technology;technology validation;Testing;Therapeutic;Tissues;tool;Translating;United States;Vascular Diseases;vascular risk factor;White Matter Hyperintensity;Wisconsin;Work

PROJECT_TITLE: Non-Invasive Imaging Markers to Elicit the Role of Vascular Involvement in Alzheimer’s Disease

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Aging;Physical Activity;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Extracellular vesicles (EVs) are microscopic particles, produced by all cells in the body, that circulate in the trillions in every milliliter of blood. EVs can potentially provide signatures of aging and resilience and carry proteins and other molecules that can communicate and have effects at a distance. Using large numbers of already collected precious human specimens from individuals aged 20 to over 90 years old, this project characterizes the types and role of these vesicles in aging and develops new blood biomarker tests for these vesicles to better understand mechanisms of aging and the ability to recover from stressors with aging.

PI_NAMEs: KRAUS, VIRGINIA  (contact)

PROGRAM_OFFICER_NAME: RAGHAVACHARI, NALINI

PROJECT_TERMS: Address;Age;age related;age related decline;aged;Aging;aging biomarker;aging mechanism;aging process;Antigen-Presenting Cells;Autophagocytosis;Baltimore;Behavior;Biological Markers;Biological Models;Biological Process;Biology;Blood;Body Fluids;Cardiovascular system;Cell Aging;Cell model;cell type;Cells;Chondrocytes;Clinical;cohort;Cohort Studies;Collaborations;Communication;Complex;cytokine;Data;data de-identification;Data Set;Defect;Elderly;epidemiology study;Exercise;exercise intensity;exercise training;extracellular vesicles;Fibroblasts;Fluorescence;follow-up;Funding;Funding Opportunities;geroprotector;Goals;Health;healthy aging;Hematopoietic stem cells;Hip Fractures;Hip region structure;Homeostasis;Human;human old age (65+);Immune;immune function;Immune system;immunoregulation;immunosenescence;improved;In Vitro;Individual;Inflammaging;Inflammation;insulin sensitivity;interest;Interleukin-6;Knowledge;Laboratories;life span;Literature;Longevity;Mammalian Cell;Measures;Mediating;Mediator;Metabolic;Methodology;Methods;MicroRNAs;Microscopic;milliliter;Mitochondria;mode of exercise;Mus;muscle metabolism;Myocardial Ischemia;nanoparticle;Natural Killer Cells;Nucleic Acids;Operative Surgical Procedures;Organism;Outcome;Oxidative Stress;Parents;Participant;particle;Patients;PECAM1 gene;peripheral blood;Phenotype;Physical activity;Physical Performance;Physiological;Plasma;Play;Population;predictive marker;Production;promote resilience;Proteins;Proteome;Randomized;Recovery;Regenerative capacity;Regulation;Reperfusion Injury;resilience;resilience biomarker;Resolution;Resources;responders and non-responders;response;RNA;Role;Sampling;secondary analysis;senescence;Serum;Sorting;Specimen;stem cells;stressor;Surface;Testing;Tissues;trafficking;United States National Institutes of Health;Validation;Vesicle;vesicular release;Video Microscopy;WI 38 cell

PROJECT_TITLE: Extracellular Vesicle Analyses to Develop Aging and Resilience Biomarkers

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Women's Health Research

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative Invasive ductal carcinoma of the breast (IDC) is very common and is associated with poor outcomes making this disease a major public health issue. We propose to study the metabolic interactions between different cells in these tumors to determine if this drives aggressive cancer. The discovery of new metabolic mechanisms that promote aggressive disease may enable us to better predict outcomes and how to overcome this with targeted drugs.

PI_NAMEs: MARTINEZ OUTSCHOORN, UBALDO  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: 6-Phosphofructokinase;Apoptosis;Apoptosis Regulation Gene;Automobile Driving;BCL2 gene;Binding;Biochemical;cancer cell;carcinogenesis;Carcinoma;Catabolism;caveolin 1;Cell Compartmentation;Cell Death;Cell Proliferation;Cells;Clinical Trials;Coupled;Coupling;Cyclin D1;Data;Disease;Disparate;Down-Regulation;Drug Targeting;ductal breast carcinoma;Enzymes;experimental study;Fibroblasts;Fructose;Future;Genes;Genetic Epistasis;Glucose;Glycolysis;Glycolysis Induction;Growth;HIF1A gene;Human;IL6 gene;In Vitro;in vivo;infiltrating duct carcinoma;Inflammation;Inflammatory;knock-down;Knowledge;Link;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;Metabolic;metabolic abnormality assessment;Metabolic Pathway;Metabolism;Mitochondria;mitochondrial fitness;Modeling;Mus;neoplastic cell;NF-kappa B;novel;novel therapeutics;Outcome;outcome prediction;overexpression;Oxidation-Reduction;Oxidative Phosphorylation;Oxidative Stress;Pathway interactions;patient subsets;Pentosephosphate Pathway;predictive marker;Prognostic Marker;Proliferating;Public Health;Resistance;Role;Sampling;Signal Transduction;sound;Stromal Cells;Testing;TGFB1 gene;Therapeutic;TP53 gene;Transforming Growth Factor beta;tumor;tumor growth;tumor metabolism;tumor microenvironment;Tumor Promotion;uptake;Variant

PROJECT_TITLE: Tumor Microenvironment Metabolism in Invasive Ductal Carcinoma of the Breast


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Telehealth

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: Project Narrative Sexually transmitted infections (STI) disproportionately affect adolescents, and adolescents often rely on emergency departments (ED) for care. This application proposes to leverage health information technology in the ED by 1) integrating patient reported outcomes into the electronic health record to drive patient-engaged clinical decision support for improved STI detection, and 2) using mobile health through two-way text messaging for improved STI treatment to improve adolescent sexual health outcomes and reduce disparities in the STI epidemic. The development of an ED-based intervention to tackle the STI epidemic through implementation of broad screening into the clinical workflow is timely and needed as it may confer significant public health impact and is consistent with the mission of Healthy People 2030.

PI_NAMEs: GOYAL, MONIKA KUMARI (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Adherence;Adolescent;adolescent sexual health;Affect;Black race;burden of illness;Cities;Clinical;clinical decision support;clinical practice;Communities;computerized;Computers;cost;Data;Data Reporting;design;Detection;Development;Diagnosis;Disparity;disparity reduction;Effectiveness;Electronic Health Record;Electronics;Emergency Care;Emergency Department-based Intervention;Engineering;Epidemic;Fright;Future;General Population;Goals;Health;health assessment;health care availability;health care disparity;health care quality;health disparity;health information technology;Health Services;Health Services Accessibility;Health Technology;Healthcare;high risk;high risk population;high-risk adolescents;Hispanic;Human;improved;infection management;infection rate;innovation;interest;Interruption;Intervention;Interview;Judgment;marginalization;Measures;Mentored Patient-Oriented Research Career Development Award;mHealth;Mission;Modeling;Not Hispanic or Latino;Outcome;outcome disparities;Paper;patient engagement;Patient Outcomes Assessments;Patient-Centered Care;Patients;Pediatric Hospitals;Persons;Pilot Projects;Policies;Population;population health;pragmatic trial;Privacy;Process;process improvement;provider adherence;Public Health;Randomized;randomized trial;randomized, clinical trials;Reporting;Research;Resources;Risk;Risk Assessment;risk stratification;screening;Series;Services;Sexual Health;Sexually Transmitted Diseases;shared decision making;social stigma;Source;stem;STI prevention;Surveys;Testing;Text Messaging;text messaging intervention;Time;tool;Transportation;treatment adherence;treatment as usual;treatment program;trial design;two way texting;Visit;vulnerable adolescent;Work;Youth

PROJECT_TITLE: Improving Adolescent Sexual Health Outcomes using Health Information Technology

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Asthma;Clinical Research;Cystic Fibrosis;Genetics;Lung;Pediatric;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Despite advances in therapy, people with cystic fibrosis (CF) develop progressive airway obstruction that is worsened by airway smooth muscle dysfunction. In this proposal, we will study how the CF disease modifier TGF drives CF lung disease through airway smooth muscle dysfunction and define its mechanism of action. These results will directly improve our understanding of CF obstructive airway disease and identify novel therapeutic targets to improve the health of children with CF.

PI_NAMEs: KRAMER, ELIZABETH L (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Address;Adrenergic beta-Agonists;airway epithelium;airway hyperresponsiveness;airway obstruction;Animals;Automobile Driving;Bioinformatics;Biological Assay;Bronchial Spasm;Calcium;career;Career Mobility;Caring;Cell Culture Techniques;Cell model;Child Health;children with cystic fibrosis;Clinical;Coculture Techniques;Coupled;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis airway epithelia;cystic fibrosis mouse;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;cytokine;Data;Defect;Development;Developmental Biology;Disease;Doctor of Philosophy;Dose;early cystic fibrosis;Environment;Epithelial Cells;Epithelium;Etiology;experimental study;Exposure to;Functional disorder;functional loss;Genes;Genetic;Genetic Diseases;Genetic Polymorphism;Goals;Grant;Human;Immunology;improved;In Vitro;in vivo;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;innovation;K-Series Research Career Programs;Knockout Mice;Laboratories;Link;Lung;Lung Diseases;Mechanics;Mediating;Mentors;Modeling;Molecular and Cellular Biology;Molecular Biology;Molecular Biology Techniques;Morphology;mouse model;Mus;Muscle function;Mutation;new therapeutic target;novel;obstructive airway disease;paracrine;Paracrine Communication;Pathogenesis;Pathologic;Pathology;Pathway interactions;Pediatric Hospitals;personalized medicine;Persons;Phenotype;Physicians;Physiology;PIK3CG gene;Positioning Attribute;Primary Cell Cultures;Production;Professional Competence;programs;Proliferating;Proteins;Publishing;Pulmonary Cystic Fibrosis;pulmonary function;pulmonary function decline;Pulmonary Pathology;Pulmonology;Reporting;Research;Research Design;Research Personnel;Resistance;respiratory smooth muscle;response;Role;Science;Scientist;Severities;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;Solid;Stimulus;success;targeted treatment;Techniques;Testing;Tissues;Training;transcriptome sequencing;Transforming Growth Factor beta;Transgenic Mice;Translational Research;translational study;Writing

PROJECT_TITLE: TGF-Beta Regulates CFTR-Mediated Airway Smooth Muscle Dysfunction

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Stroke

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE  The objective of this project is to validate an innovative diagnostic ultrasound imaging technology that will allow for noninvasively detecting atherosclerotic plaques that have high chance of rupturing, which will result in heart attacks and strokes. The innovative technology so called super resolution ultrasound imaging provides unprecedented high resolution that enables to image abnormal growth of microvessels in atherosclerotic plaques at great details, which is well known as a key indicator of plaque rupture. If successfully validated through novel rabbit plaque rupture model that is known to be most close to human plaques, the technology development and findings through this project will provide strong foundation and potential for future clinical translation. Upon successful clinical validation in future on human subjects, an immediate clinical application will be for carotid atherosclerosis clinics where this imaging technology incorporated into a current ultrasound scanner will be able to identify plaques at high risk of rupture for most appropriate interventions or/and treatments to prevent strokes and save life. The immediate outcomes from this project include an accurate, affordable, well-validated robust animal imaging tool for important diseases which are associated with microvessel abnormalities such as atherosclerotic plaques proposed in this project, cancer angiogenesis, and kidney diseases to name a few.

PI_NAMEs: KIM, KANG  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: 3-Dimensional;Acoustics;acute coronary syndrome;Address;Affect;Algorithms;angiogenesis;Animal Disease Models;animal imaging;Animals;Area;Arterial Fatty Streak;atherosclerotic plaque rupture;Autopsy;Blood Vessels;Bolus Infusion;Carotid Atherosclerotic Disease;Characteristics;Cholesterol;Clinic;Clinical;clinical application;clinical translation;clinically relevant;Confocal Microscopy;contrast enhanced;Contrast Media;Data;density;Devices;Disease;Europe;Feasibility Studies;Foundations;Frequencies;Future;Goals;Growth;high resolution imaging;high risk;Histology;Human;human subject;Image;image reconstruction;imaging approach;imaging capabilities;Imaging Device;imaging probe;Imaging technology;In Vitro;in vivo;Infiltration;Influentials;Injections;innovation;innovative technologies;Intervention;Intravenous;Investigation;Kidney Diseases;Life;Logistic Regressions;Logistics;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;meter;Microbubbles;microCT;Microfluidics;microscopic imaging;Modeling;Morbidity - disease rate;mortality;Myocardial Infarction;Names;neovascularization;Noise;Non-Invasive Detection;novel;Optics;Oryctolagus cuniculus;Outcome;Pathology;patient stratification;Performance;Physiologic pulse;Physiological;Pilot Projects;Play;Population;Preventive treatment;Procedures;Radiation;Resolution;Risk;ROC Curve;Role;Rupture;Scanning;Senile Plaques;Signal Transduction;spatiotemporal;Specificity;Stroke;Stroke prevention;stroke risk;Surrogate Markers;System;Techniques;technology development;Testing;tomography;tool;translational goal;ultra high resolution;Ultrasonography;ultrasound;United States;uptake;Validation;vasa vasorum;Work

PROJECT_TITLE: Super Resolution Ultrasound Imaging of Vasa Vasorum to Characterize the Progression of Atherosclerotic Plaques and Predict Rupture Vulnerability

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: NARRATIVE The proposal presents a new paradigm for apoptosis induction based on morpholino oligonucleotide hybridization at the cell surface. This novel approach will be developed into a new class of drug-free macromolecular therapeutics suitable for the treatment of various B cell malignancies.

PI_NAMEs: KOPECEK, JINDRICH H. (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Actins;Adhesions;Albumins;anti-CD20;Antibodies;Apoptosis;Apoptotic;B lymphoid malignancy;Binding;Calcium;Caspase;CD20 Antigens;Cell Separation;Cell surface;Cells;Cessation of life;chemotherapeutic agent;chemotherapy;Chlorambucil;Chronic Lymphocytic Leukemia;Clinical;Combined Modality Therapy;Complex;crosslink;Cyclophosphamide;Cytoskeleton;design;Diagnosis;Diffuse Large-Cell Lymphoma;Disease;Disease Resistance;disulfide bond;Doxorubicin;drug efficacy;Ensure;Evaluation;Exposure to;FDA approved;Female;flexibility;Follicular Lymphoma;Generations;Genes;genetic predictors;Goals;Half-Life;Heavy-Chain Immunoglobulins;Human;improved;In Vitro;in vivo;in vivo evaluation;indexing;Induction of Apoptosis;large cell Diffuse non-Hodgkin's lymphoma;Length;Lymphoma;Lymphoma cell;Lysosomes;macromolecule;male;Mantle Cell Lymphoma;Mediating;Membrane Microdomains;Modeling;Modification;Molecular Conformation;MS4A1 gene;mutational status;Nanoconjugate;neonatal Fc receptor;Non-Hodgkin's Lymphoma;novel;novel drug class;novel strategies;novel therapeutics;Oligonucleotides;Outcome;Pathway interactions;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;Prednisone;prognostic;receptor;Recurrent disease;Relapse;Resistance;response;rituximab;Sampling;Serum Albumin;Somatic Mutation;Structure;System;Testing;Therapeutic;thioether;Time;tositumomab;translational potential;Treatment Efficacy;treatment strategy;tumor;Vertebral column;Vincristine

PROJECT_TITLE: Drug-Free Macromolecular Therapeutics

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: GALVESTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE The University of Texas Medical Branch Summer Institute in Biostatistics and Data Science will expose rising junior and senior undergraduate students to the field of biostatistics and data science, with the purpose to expose them to opportunities presented by careers in biostatistics and to encourage them to pursue advanced degrees in the field. As a result, the Summer Institute in Biostatistics and Data Science will directly advance the mission of the NIH by expanding the expertise of biomedical researchers working to improve the nation's health by utilizing active and experiential learning along with a hands-on research project to encourage more individuals to seek careers in biostatistics and data science.

PI_NAMEs: SPRATT, HEIDI  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Academia;Active Learning;Address;analytical tool;Area;Basic Science;Biomedical Research;Biometry;Biostatistical Methods;Candy;Cardiovascular Diseases;career;career development;Case Study;Chronic Obstructive Pulmonary Disease;Communicable Diseases;Complex;Computer software;Data;Data Analyses;Data Science;Data Scientist;Data Set;Degree program;design;Disease;disorder prevention;Education;Effectiveness;Emerging infection;Ensure;experience;Experimental Designs;Exposure to;faculty mentor;Goals;Graph;grasp;Hand;hands on research;hands-on learning;Health;Heart Diseases;heart function;Hematological Disease;Hypersensitivity;Immune;improved;Individual;inferential statistics;innovation;interest;Investigation;journal article;Knowledge;lectures;Lung Diseases;machine learning method;Mediating;Medical;meetings;Mentors;Methods;Mission;Modeling;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;Outcome;Participant;Play;preclinical study;programs;Publications;Qualifying;recruit;Reporting;Reproducibility of Results;Research;Research Design;Research Personnel;Research Project Grants;research study;Resources;Role;skills;Sleep Disorders;Solid;Statistical Computing;Statistical Models;stem;Stroke;student mentoring;Students;summer institute;Techniques;Testing;Texas;tool;Training;training opportunity;Tuberculosis;undergraduate student;United States National Institutes of Health;Universities;user-friendly;vaccine development;Vocational Guidance;Walking;Work

PROJECT_TITLE: The University of Texas Medical Branch Summer Institute in Biostatistics and Data Science (UTMB-SIBDS)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Brain-derived neurotrophic factor (BDNF) has been established to be an important plasticity factor implicated in depression and anxiety disorders, due to its decreased levels in the adult CNS. We propose here to study the requirement of BDNF during peri-adolescence in regulating the development and function of a specific social behavior circuit. As social behavioral impairments are key features of these affective disorders, our studies point to a new function for this brain growth factor.

PI_NAMEs: LEE, FRANCIS SANG YONG (contact);LISTON, CONOR M

PROJECT_TERMS: Acute;Adolescence;Adolescent;Adolescent Development;Adult;Amygdaloid structure;Anxiety;Anxiety Disorders;approach behavior;autism spectrum disorder;Behavior;Behavior Therapy;Behavioral;behavioral impairment;behavioral outcome;Biological Assay;Brain;Brain region;Brain-Derived Neurotrophic Factor;Calcium;cell cortex;common symptom;Costs and Benefits;critical developmental period;Data;Decision Making;design;Development;disabling symptom;Disease;Electrophysiology (science);Exhibits;Fiber;Future;Genetic;Growth Factor;Hippocampus;Human;Imaging Techniques;in vivo calcium imaging;Knock-in Mouse;Knockout Mice;life span;loss of function;LoxP-flanked allele;Medial;Mediating;Mental Depression;Mental disorders;Molecular;Mood Disorders;Motivation;Mus;mutant;neural correlate;neuroimaging;Neuromodulator;Neurons;Neuropeptides;neuropsychiatric disorder;nonhuman primate;novel;optogenetics;Outcome;overexpression;Oxytocin;periadolescent;Pharmacologic Substance;Photometry;Play;Point Mutation;Prefrontal Cortex;Prevalence;Primates;Reagent;Rodent;Role;Schizophrenia;Shapes;Signal Transduction;social;social anxiety;Social Behavior;social deficits;Social Development;Social Functioning;Social Interaction;Synaptic plasticity;Techniques;Testing;Time;tool;Update;Ventral Tegmental Area;Viral;Visualization;Wild Type Mouse;Withdrawal;young adult

PROJECT_TITLE: Impact of BDNF on the Development of Social Behavior Circuits

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Data Science

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE The Colorado Summer Institute in Biostatistics (CoSIBS) responds to the “Call to Action” to train the next generation of biostatisticians and data scientists. The institute fills an important need in the western US. The program is led by experienced teaching and collaborative faculty with a strong commitment to biostatistics education. CoSIBS has inspired the next generation of biostatistician scientists to meet the long-term needs for new methods, study design, data analysis, and scientific leadership to assure the continued success of biomedical research as a cornerstone of public health practice and patient care.

PI_NAMEs: GOERG, CARSTEN ;WAGNER, BRANDIE  (contact)

PROJECT_TERMS: Achievement;Active Learning;Area;Articulation;Behavioral;Big Data;Bioinformatics;biomedical data science;Biomedical Research;Biometry;career;Caring;Collaborations;Colorado;Companions;Computer software;Computers;Course Content;Data Analyses;Data Science;Data Scientist;Development;Diagnosis;disorder prevention;Education;education research;Educational Curriculum;Educational process of instructing;Elements;Environment;Ethics;Evaluation;experience;Exposure to;Faculty;faculty mentor;Fellowship;field trip;follow-up;Foundations;frontier;Genetic;graduate school;graduate student;Health Sciences;Hour;Housing;Human;Informatics;Infrastructure;innovation;Institution;Instruction;interest;Laboratories;Lead;Leadership;Mathematics;Medical;Mentors;Methods;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;next generation;Participant;Patient Care;Preparation;Program Evaluation;programs;Public Health Practice;Public Health Schools;Publications;recruit;Recruitment Activity;Research;Research Design;Research Ethics;Research Personnel;Research Project Grants;Resources;responsible research conduct;Science;Scientist;statistics;STEM program;Structure;Students;success;summer institute;System;theories;tool;Training;undergraduate student;Underrepresented Populations;Universities;Work

PROJECT_TITLE: The Colorado Summer Institute for Research Education in Biostatistics (CoSIBS)


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Prevention;Rare Diseases;Skin Cancer

ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE This project focuses on understanding how mechanisms associated with chronic tissue damage influence the development and progression of squamous cell carcinoma (SCC). Our proposal builds on our previous findings that similarities exist between a rare genetic SCC disease model, recessive dystrophic epidermolysis bullosa (RDEB) and metastatic subtypes of sporadic head and neck SCC. Our goal is to identify and characterize the molecular events contributing to tumor initiation and progression in the context of tissue damage, with the over- arching aim of uncovering potential new avenues for the effective prevention and treatment of SCC.

PI_NAMEs: SOUTH, ANDREW  (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Acids;activation-induced cytidine deaminase;Address;advanced disease;Age;Alcohol consumption;Anatomy;apolipoprotein B mRNA editing enzyme;Automobile Driving;Biochemical;Biological Assay;Biological Availability;carcinogenesis;CDKN2A gene;Cell secretion;Cell Separation;Cells;Cervix Uteri;Cessation of life;Chronic;chronic wound;Clinical Markers;clinically relevant;Collagen;cytokine;Data;Deaminase;Development;disease model;Elements;Environment;environmental tobacco smoke exposure;Enzymes;Epidermolysis Bullosa Dystrophica;epithelial to mesenchymal transition;Epithelium;Esophagus;Event;experimental study;Extracapsular;Extracellular Matrix;Extracellular Matrix Proteins;Family;Fibroblasts;Fibrosis;Gene Expression;Gene Expression Profiling;Gene Mutation;Genes;Genetic;Genetic Skin Diseases;Genome;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Human papilloma virus infection;Immune;improved;In Vitro;in vivo;Induced Mutation;Infection;Inflammation;Inflammatory;Inherited;inhibitor;Intervention;Invaded;keratinocyte;Lung;lymph nodes;Malignant Neoplasms;Mediator;microbial;Molecular;mortality;mouse model;Mutagenesis;Mutation;Mutation Analysis;mutation assay;Neoplasm Metastasis;novel;Oral cavity;Organism;Outcome;Pathologic;Pathway interactions;Patients;permissiveness;PIK3CG gene;polypeptide;Population;pre-clinical;Predisposition;premalignant;prevent;Prevention;Process;Prognosis;Proliferating;Recurrent tumor;Regulation;Reporting;Research;response;Risk Factors;Role;Signal Transduction;single-cell RNA sequencing;Site;Skin;Skin Carcinoma;skin squamous cell carcinoma;Somatic Mutation;Squamous cell carcinoma;Stimulus;Testing;Therapeutic Intervention;Thrombospondin 1;Tissues;Tobacco use;TP53 gene;Transforming Growth Factor beta;Transgenic Animals;Transgenic Mice;tumor;Tumor Cell Invasion;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;Urethra;Viral;Vulva

PROJECT_TITLE: Tissue Damage-Driven Squamous Cell Carcinoma


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: NARRATIVE Multiple sclerosis is a debilitating neurological disease caused by immune-mediated loss of myelin in the central nervous system. While existing drugs that downregulate the immune system provide some benefit, no therapies are available that can regenerate lost myelin and reverse neurological deficits. Our proposed aims will use organic synthesis as a key tool to build upon a highly novel sterol signaling mechanism we recently uncovered that explains how dozens of small-molecule drugs promote myelin repair. These studies are likely to identify optimized EBP inhibitors to accelerate the development of the first ‘remyelinating therapeutics’ while also identifying new sterol-binding drug targets for promoting myelin repair.

PI_NAMEs: ADAMS, DREW JAMES (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Acceleration;Affinity;Antihistamines;Axon;Binding;Biology;Brain;brain cell;Brain Stem;Cell Physiology;Cells;cellular targeting;Central Nervous System;Chemicals;Cholesterol;cholesterol biosynthesis;Clinical;Data;Demyelinating Diseases;Development;disability;Disease;drug candidate;drug development;drug discovery;Drug Targeting;Enhancers;enzyme biosynthesis;Enzyme Inhibition;Enzymes;Family;FDA approved;Future;Goals;high throughput screening;Human;Immune;Immune system;immunoregulation;In Vitro;in vivo;in vivo evaluation;inhibitor;innovation;Lead;Libraries;Lipids;Mass Spectrum Analysis;Mediating;Medicine;Membrane;Modeling;mouse model;multidisciplinary;Multiple Sclerosis;multiple sclerosis patient;Mus;Myelin;Natural regeneration;Nature;Nervous System Disorder;Neural Conduction;Neurologic Deficit;Neurons;Neurophysiology - biologic function;new therapeutic target;novel;oligodendrocyte progenitor;Oligodendroglia;Optic Nerve;Optic Neuritis;Organic Synthesis;Organoids;oxysterol binding protein;Pathway interactions;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;prevent;Property;Proteins;Proteome;Publishing;Reagent;receptor;regenerative therapy;remyelination;repaired;Reporting;Research Personnel;Role;screening;Series;Signal Transduction;Signaling Molecule;small molecule;small molecule libraries;stem cells;Steroids;Sterols;Structure-Activity Relationship;success;Techniques;Testing;Therapeutic;tool;Work

PROJECT_TITLE: New sterol-binding targets and optimized EBP inhibitors for promoting remyelination

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE The hemodynamic response induced by neural activity is the principal means of studying brain function and brain connectivity in humans and animals. Methods like functional magnetic resonance imaging (fMRI) and optical imaging of intrinsic signal (OIS) are essential in basic science, developmental, cognitive and clinical studies of normal and impaired brain function. This proposal will reveal the contributions of sub-populations of inhibitory neurons on vascular regulation and imaging signals like fMRI and OIS to improve our understanding of brain function and dysfunction in health and disease.

PI_NAMEs: VAZQUEZ, ALBERTO L (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Air;Animals;Autopsy;awake;Basic Science;Blood flow;Blood Vessels;Brain;brain dysfunction;Brain imaging;Brain region;cell cortex;cell type;Cerebrovascular system;Clinical;Clinical Research;Cognitive;Complex;design;Development;Disease;Early Diagnosis;Experimental Designs;experimental study;Fluorescence;Foundations;frontal lobe;Functional disorder;Functional Magnetic Resonance Imaging;GABA Receptor;Glutamate Receptor;Goals;Head;Health;hemodynamics;Human;human subject;Image;imaging study;improved;inhibitory neuron;insight;Location;Measures;Methods;Modeling;Monitor;mouse model;multimodality;Mus;Nerve Degeneration;Nervous System Disorder;neural;Neurons;neurovascular;Nitric Oxide Synthase;Nitric Oxide Synthase Type I;optical imaging;Optical Methods;optogenetics;Parvalbumins;Pathway interactions;Physiology;Population;Positioning Attribute;Regulation;Reporter;Reporting;response;Rest;Role;Sensory;Shapes;Signal Transduction;Somatosensory Cortex;Somatostatin;Techniques;Tissues;Transgenic Mice;Vascular blood supply;Vasoactive Intestinal Peptide;Vibrissae;Viral;Work

PROJECT_TITLE: Inhibitory Neuron Sub-populations and Their Influence on Hemodynamic Imaging

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Bioengineering;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative The proposed studies will establish a basis for treating impairments in limb coordination during walking that result from spinal cord injury (SCI), stroke, or Parkinson’s disease, as well as those associated with normal aging. A better understanding of the neural and biomechanical mechanisms controlling limb coordination before and after SCI will provide essential insights for the development of future clinical strategies to restore and promote motor functions by identifying specific targets (e.g. reflexes, muscle synergies) for activity-based interventions, such as electrical or pharmacological stimulation.

PI_NAMEs: FRIGON, ALAIN ;PRILUTSKY, BORIS I;RYBAK, ILYA A (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Address;Animal Model;Animals;Bilateral;Biomechanics;Brain;central pattern generator;Cervical;Chest;Clinical;Collaborations;Communication;Complex;Computer Models;Cutaneous;Data;Development;Disease;Electromyography;Environment;Equilibrium;experimental study;Family Felidae;Feedback;Felis catus;Future;Gait;goal oriented behavior;Hindlimb;human model;Impairment;improved;insight;Interneurons;Intervention;kinematics;Knowledge;Left;limb movement;Limb structure;Locomotion;Locomotor Recovery;Mammals;Mediating;Modeling;Motion;Motor;Motor Neurons;Movement;Movement Disorders;Muscle;Musculoskeletal;Musculoskeletal System;Nervous System;Nervous System Disorder;neural;neural circuit;neural model;Neural Pathways;Neuromechanics;Neurons;neuroregulation;normal aging;Parkinson Disease;Pathway interactions;Pattern Formation;Persons;pharmacologic;Property;receptor;Recovery;Reflex action;Research Personnel;sensory feedback;simulation;Speed;Spinal;Spinal Cord;Spinal cord injury;Spinal Cord transection injury;spinal pathway;spinal reflex;Stroke;Study models;synergism;Testing;translational impact;treadmill;Universities;Walking

PROJECT_TITLE: Limb coordination during locomotion before and after spinal cord injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE Efficient generation of contractile force in muscle requires the proper assembly, maintenance and activation of actin-containing thin filaments. Here we propose to take a multidisciplinary approach to decipher how the leiomodins (LMODs), a family of actin-binding proteins, regulate assembly and activation of the thin filament and how mutations in LMOD2 lead to human dilated cardiomyopathy. These studies will provide missing links in our basic understanding of muscle contraction and have a broad impact on determining the etiology of a spectrum of diseases, across all three muscle types, that result from mutations in the LMOD family of genes.

PI_NAMEs: GREGORIO, CAROL C (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Actin-Binding Protein;Actins;Actomyosin;Affect;Antisense Oligonucleotides;Binding;Biochemistry;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cellular biology;Clinical;clinically relevant;Complementary DNA;Data;design;Dilated Cardiomyopathy;Disease;disease-causing mutation;Etiology;Family;Family member;Frameshift Mutation;Functional disorder;Funding;Future;Gene Family;Generations;Genes;Genetic;Goals;Hand;Heart;Heart failure;heart function;Human;human disease;human model;Impairment;improved;in vitro Assay;in vivo;induced pluripotent stem cell derived cardiomyocytes;insight;interdisciplinary approach;Intestines;Knock-out;Knockout Mice;Lead;Length;Link;Maintenance;Mechanics;Mediating;Messenger RNA;Microfilaments;Molecular Biology;mouse model;mRNA Decay;Mus;Muscle;Muscle Contraction;Muscle function;Muscle Weakness;mutant;Mutation;Myocardium;Myopathy;Nemaline Myopathies;Neonatal;neonate;Nonsense Mutation;novel;overexpression;patient derived induced pluripotent stem cells;Patients;Physiological;Play;Predisposition;premature;prevent;Process;Protein Binding Domain;protein expression;Protein Family;Protein Isoforms;Protein Truncation;Proteins;Regulation;RNA Splicing;Role;Skeletal Muscle;Smooth Muscle;spatial relationship;Structure;Syndrome;Terminator Codon;Therapeutic Intervention;Thin Filament;tool;Transcript;Tropomyosin;Work

PROJECT_TITLE: Deciphering the role of Lmod2 in cardiac muscle and in dilatedcardiomyopathy

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: A mutation in the C9orf72 gene causes ~25% of cases of frontotemporal dementia (FTD), the most common type of inherited dementia after Alzheimer’s disease. The mechanisms by which the repeat expansion leads to disease is not known. Our studies will test if protein degradation pathway previously associated with cancer might also be leveraged to treat or diagnose this currently incurable disease.

PI_NAMEs: KALB, ROBERT G (contact);LAMITINA, SAMUEL T

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Ablation;Alzheimer's Disease;Antineoplastic Agents;Arginine;Biochemical;Biological;Biological Assay;Biological Models;BRD2 gene;Bromodomain;C9ORF72;Caenorhabditis elegans;cancer therapy;Cell model;Cells;Cerebral cortex;CUL3 gene;Cullin Proteins;Degradation Pathway;Dementia;Development;Diagnosis;Dipeptides;Disease;druggable target;Endometrial Carcinoma;Exhibits;Experimental Models;frontal lobe;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;gene conservation;Gene Expression;Genes;Genetic;Genetic Screening;Genetic Transcription;Glycine;Homologous Gene;Inherited;inhibitor;insight;Introns;knock-down;Label;Lead;Link;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Missense Mutation;Modeling;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neuroprotection;novel;novel therapeutics;Nuclear;nucleocytoplasmic transport;Pathogenesis;Pathologic;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Peptides;Phenotype;Physical condensation;programs;progressive neurodegeneration;Proline;Property;protein degradation;Proteins;Proteomics;Renal Carcinoma;RNA;Role;small molecule;small molecule inhibitor;stress granule;System;targeted treatment;Temporal Lobe;Testing;Toxic effect;Transcription Regulatory Protein;transcriptome sequencing;Translations;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Defining mechanisms underlying C9orf72-associated frontotemporal dementia with C. elegans and mammalian models

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW HAVEN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Burd: Project Narrative Within the cell, internal compartments called organelles function as factories that make certain molecules that comprise the cell. This research project investigates how molecules are sorted and trafficked to different organelles. Defects in these pathways lead to cancer, diabetes, Alzheimer's and other neurological diseases, and cardiovascular disease.

PI_NAMEs: BURD, CHRISTOPHER G (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Alzheimer's Disease;Cardiovascular Diseases;Cell membrane;Cells;Cholesterol;cohort;Data;Defect;Diabetes Mellitus;Endoplasmic Reticulum;Eukaryotic Cell;Glycerophospholipids;Golgi Apparatus;Homeostasis;Knowledge;Lead;lipid transfer protein;Lipids;Malignant Neoplasms;Membrane;Membrane Lipids;Nervous System Disorder;Organelles;Pathway interactions;Phosphatidylinositols;Phospholipids;Protein Biosynthesis;protein function;Proteins;Regulation;Research;Research Project Grants;Role;sensor;Signaling Protein;Site;Sorting;Sphingolipids;Sphingomyelins;System;Testing;trans-Golgi Network

PROJECT_TITLE: Lipid Dynamics in the Golgi Apparatus

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Clinical Research;Hematology;Lung;Pulmonary Hypertension;Rare Diseases;Sickle Cell Disease

ORG_STATE: CO

PHR: RELEVANCE Cell free hemoglobin and iron accumulate in circulating monocytes/macrophages that are subsequently recruited to lung. In the lung adventitial space these macrophages lose iron homeostasis (resulting in incorrect iron extrusion). This extruded iron along with extravasated Hb mediated cellualr lipid peroxia- tion, may alter the cross talk betwee adventitial fibroblasts and macrophages creating pro-inflammatory micro-environment that drives pulmonary vascular disease. The goal of our studies is elucidate the mechanistic underpinnings of this process.

PI_NAMEs: BUEHLER, PAUL WERNER;D'ALESSANDRO, ANGELO ;IRWIN, DAVID CHARLES (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: Acceleration;Adult;Affect;Animal Model;Applications Grants;arteriole;Attenuated;Biology;Blood;Blood capillaries;Blood Vessels;Cardiopulmonary;Cell Communication;Cells;Childhood;Chlorides;Circulation;Coculture Techniques;cytokine;Data;Development;Diagnosis;effectiveness testing;Endothelial Cells;enhancing factor;Erythrocytes;Erythrophagocytosis;Excision;exercise intolerance;Exercise Tolerance;Extravasation;Ferritin;Fibroblasts;Fibrosis;Functional disorder;Gadolinium;Goals;Hematological Disease;heme oxygenase-1;hemodynamics;Hemoglobin;Hemolysis;Homeostasis;Hospitalization;Human;Hypoxia;Immune response;Impairment;improved;In Vitro;in vivo;Inflammatory;inhibitor;insight;Interleukin-2;Intervention;Investigation;Iron;Iron Chelation;Iron Overload;Knock-out;Lesion;Lipids;Liver;Lung;lung hypoxia;Macrophage;Macrophage Activation;Mediating;Mediator;Metabolic;metabolomics;metal transporting protein 1;Methodology;Modeling;monocyte;multiple omics;Mus;new therapeutic target;novel;oxidation;Pathologic;Patients;Pericytes;Peripheral;peripheral blood;Persons;Phagocytosis;pharmacologic;Phenotype;Plasma;Population;primary pulmonary hypertension;Process;Proteome;Proteomics;Pulmonary arterial remodeling;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular disorder;pulmonary vascular remodeling;Pulmonary vessels;Rationalization;Rattus;recruit;response;Right Ventricular Dysfunction;right ventricular failure;Risk;Rodent Model;Role;Severities;Sickle Cell;Sickle Cell Anemia;sickling;small molecule;Sorting;Spleen;success;Syndrome;Testing;Therapeutic Intervention;therapy development;Tissues;Transferrin;Tunica Adventitia;United States;Vascular Proliferation;Vascular remodeling;Vasoconstrictor Agents

PROJECT_TITLE: The paradoxical response to iron in pulmonary hypertension of sickle cell disease

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

PHR: Project Narrative The overall goal of the IMSD program at the University of Texas at San Antonio is to provide a comprehensive evidence-based training and support infrastructure that enables underrepresented UTSA doctoral students to develop as biomedical scientists. Our trainees will contribute to public health by enhancing the creativity and productivity of the national biomedical and behavioral workforce. Those who follow an academic path will also help to diversify the nation’s universities as faculty who are more representative of all Americans.

PI_NAMEs: BAREA-RODRIGUEZ, EDWIN J (contact);BREY, ERIC M;CASSILL, AARON

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Texas;Universities

PROJECT_TITLE: IMSD at the University of Texas at San Antonio

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Autism;Brain Disorders;Eye Disease and Disorders of Vision;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Multiple hypotheses have been put forward regarding cortical circuit dysfunction in autism spectrum disorders. Nevertheless, we currently lack a comprehensive mechanistic understanding of how cortical circuits malfunction during sensory processing in autism. Here we undertake an effort to densely map cortical circuit properties and connectivity in the MECP2-duplication syndrome of autism and use this information to create a neuro-realistic cortical circuit model, which will allow a detailed, “in computo,” interrogation of the mechanism of dysfunction and how to ameliorate it. 1

PI_NAMEs: SMIRNAKIS, STELIOS MANOLIS (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Adult;Affect;Anatomy;Animals;Area;area striata;area V1;autism spectrum disorder;Behavior;Behavioral;behavioral phenotyping;Categories;Cell Communication;cell type;Cells;Collaborations;comparison control;connectome;cortex mapping;Cortical Column;Data;deep learning;Defect;design;Disease;Disease Progression;Electrophysiology (science);Equilibrium;Etiology;excitatory neuron;expectation;Failure;Functional disorder;functional improvement;functional restoration;Future;Genes;Genetic;Image;in silico;in vivo;inhibitory neuron;Intellectual functioning disability;Interneurons;Intervention;Investigation;Knowledge;Laboratories;Link;Literature;machine learning method;male;Maps;MeCP2 Duplication Syndrome;Methods;Methyl-CpG-Binding Protein 2;model of autism spectrum disorder;Modeling;mouse model;Mus;neural circuit;neural patterning;Neurons;optogenetics;patch clamp;Pattern;Penetrance;Performance;Physiological;Physiology;Population;Probability;Property;repaired;Reporting;Resolution;Retina;Rett Syndrome;Sensory;sensory cortex;Slice;Stimulus;Synaptic plasticity;Syndrome;Techniques;Testing;therapeutic target;Time;two-photon;Vision;Visual Cortex;visual processing

PROJECT_TITLE: Dense Analysis of Cortical Circuit Dysfunction in the MECP2-duplication Syndrome of Autism

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Data Science;Infectious Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Technological advances are leading to unprecedented abundance of increasingly complex, voluminous, and multi-dimensional data on a wide range of health outcomes and their determinants, including those related to lung, heart, allergy, and infectious diseases—creating a critical need to train biostatisticians and data scientists with multidisciplinary skills to properly analyze such data. Also evident is the need for a diversified workforce of biostatisticians and data scientists well-versed in public health principles to properly tackle the acute and growing challenges of health disparities. To fill this critical gap, the Summer Training Institute in Biostatistics and Data Science at Columbia (SIBDS@Columbia) proposes an innovative curriculum in quantitative skills anchored on data immersion related to research challenges in studies of heart and lung diseases as well as infectious diseases, to train the next generation of adept biostatisticians and data scientists poised to address these pressing challenges.

PI_NAMEs: BERHANE, KIROS T (contact);MAURO, CHRISTINE MARIE

PROJECT_TERMS: Acute;Address;African;analytical method;Area;Biomedical Research;Biometry;career;cohort;college;Communicable Diseases;Complex;complex data;computer science;Creativeness;Data;Data Analyses;Data Science;Data Scientist;Degree Completion;design;Development;Discipline;Education;Educational Curriculum;Educational process of instructing;Ensure;Epidemiology;ethnic diversity;experience;Faculty;Family;Funding;graduate student;Growth;Health;health disparity;Heart;Heart Diseases;Hematological Disease;Hypersensitivity;Immersion;Infectious Disease Epidemiology;Infectious Diseases Research;informatics tool;innovation;Interdisciplinary Study;job market;Latino;Location;Lung;Lung Diseases;Machine Learning;Mathematics;Mentors;Mission;Modeling;multidimensional data;multidisciplinary;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;New York City;next generation;Outcome;outreach;programs;Public Health;Recording of previous events;recruit;Research;Research Design;response;Running;Scientist;skill acquisition;skills;Sleep Disorders;sound;statistics;Structure;student mentoring;success;summer institute;System;Techniques;Technology;tool;Training;Training Programs;undergraduate student;United States National Institutes of Health;Universities;university student;Woman

PROJECT_TITLE: Summer Institute for Training in Biostatistics and Data Science at Columbia (SIBDS@Columbia)


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative The long-term goal of the IUPUI Postbaccalaureate Research Education Program (IPREP) is to improve diversity in the community of graduate students and faculty for six targeted Ph.D. programs in the biomedical and behavioral area at IUPUI. Training will be available for six students each year in areas of interest to the national health including Basic Medical Sciences, Clinical Psychology, Addictions Neuroscience, Human Performance, Medical Neuroscience, Biomedical Engineering, and multidisciplinary Artificial Intelligence, with the goal of matriculation into these graduate programs at IUPUI or similar graduate programs at other universities. This will be accomplished through laboratory research experiences and with supporting social academic, professional, and career development activities provided by IPREP.

PI_NAMEs: BAHAMONDE, RAFAEL  (contact);ROPER, RANDALL J

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: academic preparation;addiction;Address;Admission activity;African American population;Area;Articulation;Artificial Intelligence;Award;Awareness;Bachelor's Degree;Behavioral;Behavioral Research;Behavioral Sciences;Biology;Biomedical Engineering;Biomedical Research;career;Career Choice;career development;Clinical Psychology;cohort;college;Communication;Communities;Credentialing;Critical Thinking;Dedications;Development;Development Plans;disabled students;disadvantaged background;Discipline;Disparity population;Doctor of Medicine;Doctor of Philosophy;Doctor's Degree;education research;Employee;Environment;Ethnic Population;expectation;experience;Faculty;faculty mentor;Fellowship;Funding;Goals;graduate school;graduate school preparation;graduate student;Health;higher education;Hispanic-serving Institution;Historically Black Colleges and Universities;Human;Immunology;improved;Indiana;Individual;Institution;interest;Interview;Laboratories;Laboratory Research;Latino Population;literature citation;male;matriculation;Medical;medical schools;Medical Students;member;Mentors;Microbiology;Monitor;multidisciplinary;Musculoskeletal;Neurosciences;Performance;Pharmacology and Toxicology;Physiology;Population;Population Heterogeneity;Postbaccalaureate;Preparation;Process;Productivity;programs;Progress Reports;recruit;Reproducibility;Research;research faculty;Research Training;responsible research conduct;Rotation;Science;science education;Scientific Advances and Accomplishments;Secure;Self Efficacy;Series;skills;social;Social support;Students;success;Talents;text searching;Training;tribal college;undergraduate student;underrepresented minority student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Visit;Writing

PROJECT_TITLE: IPREP: IUPUI Graduate Preparation for the Biomedical and Behavioral Sciences

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Gene Therapy;Genetics;Nanotechnology;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Gene silencing using small interfering RNA (siRNA) is a viable therapeutic approach but, limited in translation due to lack of effective delivery systems. Developing effective and non-toxic delivery system will translate siRNA- based therapeutics to clinics. Here, using in vitro cell culture and in vivo animal models, we propose to develop a new type of siRNA delivery system for in vitro and in vivo gene silencing and therapeutic applications.

PI_NAMEs: BHATTACHARYA, RESHAM ;MUKHERJEE, PRIYABRATA  (contact)

PROJECT_TERMS: Animal Model;Apoptosis;Biodistribution;Biological Assay;cancer cell;Cancer cell line;Cell Culture Techniques;Chemicals;Cisplatin;Clathrin;Clinic;Clinical;clinical translation;Drug Delivery Systems;Drug Kinetics;Drug resistance;Drug Sensitization;Endocytosis;Enzymes;Exhibits;Formulation;Future;Gene Silencing;genetic approach;Glycolysis;Gold;Growth;Human;Immune system;Immunofluorescence Immunologic;In Vitro;in vivo;inhibitor;Inner mitochondrial membrane;Invaded;Lipofectamine;liposomal formulation;Liposomes;Location;Lysosomes;Malignant neoplasm of ovary;Mediating;Membrane Proteins;Metabolic;Metabolism;migration;Mitochondria;Modeling;mouse model;Mus;nanocomposite;Nanoconjugate;nanoformulation;nanoGold;nanoliposome;nanotoxicity;new therapeutic target;Normal Cell;Outcome;overexpression;Oxidative Phosphorylation;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Phenocopy;Phenotype;Prognosis;pyruvate dehydrogenase;Reagent;Reporting;Resistance;Rod;Scheme;Serous;Shapes;siRNA delivery;Small Interfering RNA;System;targeted treatment;Testing;Therapeutic;therapeutic gene;therapeutic RNA;Tissue Microarray;Tissues;Toxic effect;Transfection;translatable strategy;Translating;Translations;Treatment Efficacy;tumor;tumor growth;tumor microenvironment;uptake;Western Blotting;Xenograft procedure

PROJECT_TITLE: Normalizing aberrant metabolism in ovarian cancer by a unique drug delivery system

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]