NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: WASHINGTON

ORG_NAME: HISPANIC ACCESS FOUNDATION

ORG_STATE: DC

PHR: Project Narrative The Senderos a la Ciencia/Pathways to Science project is specifically designed to enhance workforce diversity in the health research sciences space. By offering role model talks featuring Hispanic health research professionals at a Hispanic-serving church, and by providing near-peer mentoring to Hispanic high school students interested in pursuing health science research careers, this initiative will: 1. Build awareness and value among Hispanic parents and youth in targeted under-resourced  Hispanic communities of careers in health research. 2. Engender an interest to pursue health research careers among youth in these same communities. 3. Trigger pursuing a college path in health research among high school students in these same communities. Besides initially serving Hispanics in the greater New London, Connecticut community, this project will have the potential to reach much broader Hispanic audiences. Role model talks will be featured on the project website, which will be promoted via Hispanic Access Foundation’s bilingual social media accounts. Altogether, we foresee 1,000 unique visitors to these web pages during the project period. In addition, during the dissemination phase of this project, Hispanic Access Foundation will reach out to our network of pastors representing 150,000 Hispanic-serving churches. Interested pastors will be invited to attend replication seminars where they may learn about the Senderos/Pathways project and receive guidance for launching similar projects in their own communities.

PI_NAMEs: VALENTIN FELICIANO, YASHIRA MARIE (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Astronomy;Awareness;bilingualism;Biological Sciences;career;Church;college;Communities;Connecticut;design;Ensure;Evaluation;Female;follow-up;Foundations;Health;health science research;Health Sciences;High School Student;Hispanic;hispanic community;Hispanic Populations;interest;Latino;Learning;London;male;Mentors;outreach;Parents;Pathway interactions;peer coaching;Phase;program dissemination;programs;recruit;Research;Research Personnel;Resources;role model;Schools;Science;science teacher;Scientist;Site;social media;Training;web page;web site;Youth

PROJECT_TITLE: Senderos a la Ciencia/Pathways to Science Hispanic Role Model and Mentoring Project

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety

ORG_CITY: BRONX

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward  CLINICAL PROTOCOL AND DATA MANAGEMENT - PROJECT NARRATIVE  Per PAR-21-321, a Project Narrative is not required for this Component.  OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PI_NAMEs: HALMOS, BALAZS  (contact)

PROJECT_TERMS: Binding;Budgets;Businesses;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Catchment Area;Clinical Cancer Center;Clinical Data;Clinical Investigator;clinical practice;Clinical Protocols;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Network;Collaborations;community engagement;Community Outreach;Conduct Clinical Trials;COVID-19;COVID-19 pandemic;Data;data management;Dedications;Development;Disease;Eligibility Determination;Employee;Enrollment;Ensure;Equity;Ethics;Ethnic Origin;Faculty;Funding;Good Clinical Practice;Grant;Growth;Hematology;Infrastructure;Institution;Intervention;Investigational Therapies;investigator-initiated trial;Investments;Journals;Leadership;Malignant Neoplasms;marginalized population;Medical center;Modality;Monitor;multidisciplinary;National Clinical Trials Network;neuro-oncology;operation;Operations Research;Outcome Study;Patient advocacy;patient engagement;Peer Review;Phase;Physician Executives;Principal Investigator;Procedures;process improvement;programs;protocol development;Protocols documentation;Publications;quality assurance;Race;recruit;Reporting;Research;Research Personnel;Resources;Risk;Safety;Science;Structure;success;Time;Training;Training and Education;Underrepresented Populations;underserved minority;Underserved Population

PROJECT_TITLE: Clinical Protocol and Data Management

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE/PUBLIC HEALTH RELEVANCE Altered exposure to specific placental hormones may underlie diverse neurological disorders including epilepsy, autism, or cognitive deficits. Placental hormone alterations can occur insidiously due to preeclampsia or infection (conditions seen in 5 to 10% of term pregnancies) or acutely due to preterm delivery (representing more than 10% of all US pregnancies); this loss of placental hormone exposure may place many infants at risk of impaired neurodevelopment. Our investigations in neuroplacentology, focused here on allopregnanolone—a potent neuroactive steroid made by the placenta—are important in determining how placental hormones or related compounds can provide novel treatments to ameliorate developmental brain damage due to placental dysfunction.

PI_NAMEs: PENN, ANNA A (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: 3-Dimensional;Acute;Agonist;Allopregnanolone;Apoptosis;autism spectrum disorder;Autopsy;Behavior;Brain;Brain Diseases;Brain Injuries;Cell Cycle;cell type;cellular targeting;Cognitive deficits;Data;Defect;defined contribution;density;design;Development;Dorsal;dosage;Dose;Electrophysiology (science);Enzymes;Epilepsy;Equilibrium;experimental study;Exposure to;Female;fetal;Functional disorder;functional improvement;Funding;gamma-Aminobutyric Acid;Gene Deletion;Gene Expression;Gene Proteins;Genes;Genetic Transcription;Goals;Grant;hippocampal pyramidal neuron;Hormonal;Hormones;Human;human induced pluripotent stem cells;Hydroxysteroid Dehydrogenases;Immunohistochemistry;Impairment;In Vitro;indexing;Infant;Infection;Injury;Interneurons;Investigation;Link;LoxP-flanked allele;male;Measures;Mediating;migration;Modeling;Molecular Analysis;Molecular Target;mouse model;Mus;Nervous System Disorder;neural circuit;Neuroanatomy;neurodevelopment;Neurodevelopmental Disorder;Neurodevelopmental Impairment;neurogenesis;Neurologic Dysfunctions;Neurological outcome;neuron loss;Neurons;neurosteroids;novel;novel therapeutics;offspring;Organoids;Perinatal;Placenta;Placental Hormones;Placental Insufficiency;post pregnancy;postnatal;postsynaptic;Pre-Eclampsia;Pregnancy;Premature Birth;prenatal;Prevalence;prevent;Production;Progesterone;protein expression;public health relevance;Publishing;receptor;Risk;Rodent;Role;Schizophrenia;Series;sex;Shapes;Signal Transduction;somatosensory;Somatosensory Cortex;Specificity;Specimen;System;Testing;Time;tool;Withdrawal;Work

PROJECT_TITLE: Novel Roles of Placental Allopregnanolone in Brain Development and Injury

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Cancer;Patient Safety

PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward  PROTOCOL REVIEW AND MONITORING SYSTEM - PROJECT NARRATIVE  Per PAR-21-321, a Project Narrative is not required for this Component.  OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PI_NAMEs: OHRI, NITIN  (contact)

PROJECT_TERMS: Basic Science;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Therapy Evaluation Program;Catchment Area;Charge;Clinical Protocols;Clinical Research;Clinical Research Protocols;Clinical Trials;clinically relevant;Committee Members;Data;Development;Devices;Disease;Doctor of Philosophy;drug development;Ensure;Evaluation;expectation;expedited review;experience;Funding Agency;Goals;Health Sciences;human subject protection;Individual;Industry;Institution;Institutional Review Boards;Intervention;Intervention Trial;Leadership;life span;Malignant Neoplasms;Manuals;meetings;member;Minority;Minority Enrollment;Mission;Modality;Monitor;multidisciplinary;Observational Study;operation;Patients;Peer Review;Performance;Pharmaceutical Preparations;Policies;population health;Principal Investigator;Procedures;Process;programs;Protocols documentation;Reporting;Research Personnel;Resources;Review Committee;Safety;Strategic Planning;System;Therapeutic;Translational Research;Underrepresented Populations;United States National Institutes of Health;women patients;Work

PROJECT_TITLE: Protocol Review and Monitoring System


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Despite recent innovations in diagnostic testing, nearly three million people every year develop active tuberculosis (TB) but are not adequately diagnosed – in part reflecting the paucity of evidence on how to implement patient-centered case-finding strategies. Self-testing is an innovative approach that has been successfully used to enhance the diagnosis of infectious diseases such as HIV, but self-testing has not been widely used for TB to date. In this project, I will conduct a combined implementation/effectiveness evaluation of oral swabs for molecular testing as used for self-testing in six occupational centers in South Africa (as informed by formative qualitative evidence) while gaining the training I need to become a leader in the field of patient- centered TB care. 1

PI_NAMEs: BAIK, YEON SOO  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Address;Adopted;Adoption;Age;aging population;authority;Awareness;Behavior;Behavioral Model;Biological Assay;Biological Testing;care providers;care seeking;Caring;case finding;Cessation of life;Clinic;clinical outcome assessment;Cluster randomized trial;cohort;communicable disease diagnosis;Communicable Diseases;Communities;comparison control;comparison intervention;cost;Data;design;Diagnosis;Diagnostic;Diagnostic tests;diagnostic tool;Disease;Education;Effectiveness;effectiveness evaluation;effectiveness/implementation study;empowerment;Epidemic;Epidemiologist;Epidemiology;Evaluation;Event;Focus Groups;Future;global health;global health emergency;Goals;Grant;Health;Health Services Accessibility;high risk;HIV;implementation barriers;implementation evaluation;implementation outcomes;implementation science;implementation strategy;implementation/effectiveness;Improve Access;improved;Individual;innovation;Intention;Interruption;Intervention;Interview;Laboratories;Location;Maintenance;Measures;medical attention;Methods;Modality;Molecular;Occupational;Oral;Outcome;Participant;patient oriented;Patients;Persons;Peru;Positioning Attribute;pragmatic study;pragmatic trial;primary outcome;Prospective Studies;Qualitative Methods;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Design;Resource-limited setting;Resources;satisfaction;self testing;Series;Shipping;Site;skill acquisition;skills;social norm;social stigma;South Africa;Specimen;standard of care;Structure;Surveys;Swab;Target Populations;Test Result;Testing;testing access;therapy design;therapy development;Time;tool;Training;transmission process;Travel;Tuberculosis;tuberculosis treatment;Underserved Population

PROJECT_TITLE: An implementation science approach to the design and evaluation of tuberculosis self-testing in Peru

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Data Science;Genetics;Hematology;Human Genome;Machine Learning and Artificial Intelligence;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Precision medicine holds great hope for children with cancer, but matching kids with available open clinical trials remains a challenge. The Pediatric Cancer Data Commons (PCDC) team at University of Chicago has developed GEARBOx (Genomic Eligibility Algorithm at Relapse for Better Outcomes), a tool to assist clinicians in quickly and efficiently finding a clinical trial for a patient with relapsed or refractory acute myelogenous leukemia (AML). Based on the success of the platform for AML, the PCDC now endeavors to expand GEARBOx to include several more tumor types and to develop better and faster ways to automatically collect and incorporate data into the clinical trial matching algorithm.

PI_NAMEs: VOLCHENBOUM, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Agreement;Algorithms;Biological Markers;Cancer Relapse;Characteristics;chemotherapy;Chicago;Child;Childhood Acute Myeloid Leukemia;Clinical;Clinical Data;Clinical Trials;Collaborations;Community Healthcare;Complex;cooperative study;Data;Data Commons;data sharing;Data Sources;Development;Disease;Eligibility Determination;Enrollment;Ewings sarcoma;Exclusion Criteria;Feedback;Flow Cytometry;Genomics;Hematology;Immunophenotyping;Improve Access;improved;improved outcome;International;leukemia/lymphoma;Logic;Malignant Childhood Neoplasm;Malignant Neoplasms;Manuals;Measures;Methods;Monitor;Multi-Institutional Clinical Trial;Multiomic Data;Natural Language Processing;Neuroblastoma;novel therapeutics;Osteosarcoma;Outcome;participant enrollment;Patients;Pediatric Oncologist;Pediatric Oncology;Pharmaceutical Preparations;Pharmacologic Substance;precision medicine;Precision therapeutics;Process;Protocols documentation;Rare Diseases;Recurrent disease;Refractory;refractory cancer;Refractory Disease;Relapse;Research Personnel;Resources;Rhabdomyosarcoma;Site;Societies;Solid Neoplasm;Source;Specific qualifier value;Structure;success;System;targeted therapy trials;Testing;Time;tool;tumor;Universities;unsupervised learning;usability;Visualization;Work

PROJECT_TITLE: GEARBOx - a multisite clinical trial matching tool for children with relapsed or refractory cancer


PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward  ANALYTICAL IMAGING FACILITY - PROJECT NARRATIVE  Per PAR-21-321, a Project Narrative is not required for this Component.  OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PI_NAMEs: CONDEELIS, JOHN S (contact)

PROJECT_TERMS: 3-Dimensional;Animal Model;Array tomography;Cancer Center Support Grant;cellular imaging;Clinical;cohort;college;Communities;Computer software;cost effective;Development;digital;Educational workshop;Electron Microscopy;electron tomography;Enzymes;experience;Freezing;Goals;Grant;Histocytochemistry;histological specimens;Histology;Human;Image;Image Analysis;imaging facilities;imaging platform;Imaging Techniques;Imaging technology;Immunofluorescence Immunologic;Immunohistochemistry;in vivo;Individual;Institution;instrumentation;light microscopy;Magnetic Resonance Imaging;Malignant Neoplasms;Medicine;member;Metabolism;Microscope;microscopic imaging;Microtome - medical device;mouse model;multi-photon;new technology;Paraffin;Pathology;Patients;Positron-Emission Tomography;pre-clinical;Preparation;Principal Investigator;programs;quantitative imaging;Research;Research Methodology;Research Personnel;Resource Sharing;Resources;Sampling;Scanning;Scanning Electron Microscopy;Science;Services;single photon emission computed tomography;Slide;Specimen;spectrograph;Speed;Stains;Techniques;Technology;Tissue Fixation;tissue processing;Tissues;Training;Translational Research;translational study;Transmission Electron Microscopy;tumor;ultra high resolution;United States National Institutes of Health;Validation;Visualization

PROJECT_TITLE: Analytical Imaging Facility


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: BOSTON

ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Why we age continues to be a critically unanswered question in biology. The original hallmarks of aging were described nearly a decade ago (López-Otín et al., 2013), but how they intersect and whether interactions among them cause pathological aging remains unknown. Together, these studies will provide the field with a novel set of customizable tools to track the hallmarks and test the hypothesis that many hallmarks intersect at the informational level, making them co-reversible when information in the nucleus is reset to a youthful state.

PI_NAMEs: SINCLAIR, DAVID A. (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: 3-Dimensional;adenovirus mediated delivery;Affect;Age;age acceleration;age-related disease;Aging;aging process;aging related;Appearance;Architecture;ATAC-seq;Attenuated;attenuation;Biological;biological systems;Biology;Categories;cell age;Cell Nucleus;Cell Physiology;cell type;Cells;Complex;Computer software;Cytoplasm;Data;demethylation;DNA;DNA Methylation;DNA methylation profiling;Ensure;Epigenetic age;epigenetic aging;Epigenetic Process;epigenome;epigenomics;Feedback;Female;Genetic;Genetic Variation;Genome;Genome Mappings;Genomic Segment;hallmarks of aging;Health;Human;Hybrids;Image;Impairment;in vivo;Incidence;indexing;Individual;inducible gene expression;innovation;insight;Instruction;Intervention;Knowledge;live cell imaging;Machine Learning;male;Mammals;Maps;Measures;methylation pattern;Mitochondria;Monitor;multiple omics;Mus;novel;Nuclear;Organ;pathological aging;Physiological;Process;programs;rate of aging;Reporter;Reporting;RNA;sensor technology;single cell ATAC-seq;single-cell RNA sequencing;siRNA delivery;software development;Structure;System;Technology;Testing;Time;time use;Tissue Harvesting;Tissues;tool;ultra high resolution;Work

PROJECT_TITLE: Using cellular co-biosis and age programmable mice to derive a global interaction map of aging hallmarks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-Z(52)]


PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward  ANIMAL MODEL SHARED RESOURCE - PROJECT NARRATIVE  Per PAR-21-321, a Project Narrative is not required for this Component.  OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PI_NAMEs: EDELMANN, WINFRIED  (contact)

PROJECT_TERMS: Ablation;Accreditation;Alleles;Amino Acids;animal facility;Animal Husbandry;animal imaging;Animal Model;base;base editing;Biological Sciences;Board Certification;Breeding;Cancer cell line;Cancer Center Support Grant;Cancer Model;Caring;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;conditional knockout;Constitution;cost;cost efficient;CRISPR interference;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Cryopreservation;Derivation procedure;Development;Down-Regulation;Embryo;embryo cryopreservation;embryonic stem cell;Ensure;Enterobacteria phage P1 Cre recombinase;Evaluation;Fertilization in Vitro;Gene Expression;Gene Modified;Gene Targeting;Generations;Genes;genomic locus;Genotype;germ free condition;Goals;Hematologic Neoplasms;Heterozygote;Histologic;Housing;Human;human cancer mouse model;human model;imaging system;implantation;improved;in vivo;in vivo evaluation;in vivo imaging;in vivo imaging system;inducible Cre;Injections;innovation;knock-down;Knock-in Mouse;Knock-out;Knockout Mice;Label;Maintenance;Malignant Neoplasms;Mammalian Cell;Methodology;Methods;Microinjections;Modification;mouse genome;mouse model;Mus;neoplastic cell;novel;novel anticancer drug;novel imaging technology;offspring;Oocytes;overexpression;Pathologist;patient derived xenograft model;Patients;preclinical study;preservation;Principal Investigator;programs;Proteins;red fluorescent protein;Reporter Genes;reproductive;Research;Research Personnel;Resource Sharing;RNA;Rodent;Services;Solid Neoplasm;Specificity;sperm cryopreservation;stem;Study models;System;Tamoxifen;Techniques;Technology;Tissue Model;Tissues;Transgenes;Transgenic Mice;Transgenic Organisms;Transplantation;tumor;tumor growth;tumor xenograft;Xenograft procedure

PROJECT_TITLE: Animal Model Shared Resource


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Genetics;Mental Health;Neurosciences

ORG_CITY: MADISON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The goal of this study is to develop new statistical methods, algorithms and open-source software for building large-scale embedding models of brain networks using fMRI of 1206 subjects available from the publicly available Human Connectome Project database. The proposed models and algorithms will be used to establish the base- line map for the genetic inﬂuences on brain networks at the voxel level. Considering recent surge of interests in dynamic brain network phenotypes in relation to cognition, behavior and genetics, such detailed heritability maps will be highly useful as a baseline for future studies.

PI_NAMEs: CHUNG, MOO K (contact)

PROGRAM_OFFICER_NAME: FERRANTE, MICHELE

PROJECT_TERMS: Address;Algorithms;Anatomic Surface;Anatomy;Atrophic;Behavior;behavior prediction;Brain;Brain imaging;Brain region;Bypass;Chromosome Mapping;Clinical;Cognition;Cognitive;cognitive task;Communities;complex data;Computer software;connectome;Data;Data Analyses;Data Set;data structure;Databases;Dependence;Diffusion Magnetic Resonance Imaging;Discrimination;Functional Magnetic Resonance Imaging;Future;Genetic;genetic association;geometric structure;Goals;Heritability;Human;human subject;interest;Laplacian;Magnetic Resonance Imaging;Maps;Methods;Modeling;morphometry;network models;neuroimaging;novel;open source;Outcome;Participant;Phenotype;Population;Procedures;Research;Resolution;Rest;Series;Shapes;Signal Transduction;Software Tools;Statistical Methods;Structure;Surface;Techniques;Time;tool;Twin Multiple Birth;usability;user-friendly;Visualization;Work

PROJECT_TITLE: Dynamic embedding time series models in functional brain imaging

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Prevention

PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward  BIOSTATISTICS SHARED RESOURCE - PROJECT NARRATIVE  Per PAR-21-321, a Project Narrative is not required for this Component.  OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PI_NAMEs: XUE, XIAONAN NA (contact)

PROJECT_TERMS: Address;anti-cancer research;Applications Grants;Area;Basic Science;Bioinformatics;Biological Assay;Biomedical Research;Biometry;Biostatistics Shared Resource;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Etiology;cancer prevention;Cancer Prognosis;care delivery;Clinical;Clinical Research;clinical trial protocol;Clinical Trials;Collaborations;Communities;cost effective;Data;Data Analyses;data complexity;Detection;Development;Devices;electronic health record system;epidemiology study;experience;Experimental Designs;experimental study;Fostering;Funding;Goals;health disparity;Health Services;high dimensionality;Human Resources;improved;individualized prevention;Infrastructure;innovation;interdisciplinary collaboration;Knowledge;Laboratories;Machine Learning;Malignant Neoplasms;Manuscripts;member;Mentors;Methodology;Modernization;Molecular;multidisciplinary;new technology;novel;Phase;pragmatic trial;precision medicine;Preparation;Principal Investigator;Prognosis;programs;Records;recruit;Reproducibility;Research;Research Activity;Research Design;Research Personnel;Research Priority;Resource Sharing;Resources;Role;Science;Screening for cancer;System;Technology;Training;training opportunity;Translational Research;treatment strategy;trend;wearable device

PROJECT_TITLE: Biostatistics Shared Resource


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Cancer;Immunotherapy;Networking and Information Technology R&D (NITRD)

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: The primary mission of the coordinating center of the Pre-medical Cancer Immunotherapy Network for Canine Trials (PRECINCT) is to provide infrastructure and oversight to a highly collaborative and interactive network of researchers and clinician scientists working to investigate immunotherapeutic strategies in dogs with cancer, identify correlates of immunological and therapeutic responses and determine the value of dogs with spontaneous cancers in informing human clinical trial design. Leveraging the renowned expertise of the University of Pennsylvania in human and canine immunotherapy trials, PRECINCT's coordinating center will provide expert services in project management and research technology, data management and sharing, and biostatistical and bioinformatics support to U01 awardees and network members. This work will advance discovery, promote collaborative research and accelerate the translation of safe and effective immunotherapies into the human cancer clinics.

PI_NAMEs: LONG, QI ;MASON, NICOLA J (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Acceleration;Advisory Committees;Area;Bioinformatics;Biological Markers;biomarker identification;Biometry;cancer clinical trial;cancer immunotherapy;Canis familiaris;Clinic;Clinical;Clinical Management;Clinical Research;Clinical Trials;Clinical Trials Design;Clinical Trials Network;cloud based;Collaborations;Combined Modality Therapy;Communication;Community Clinical Oncology Program;comparative;Consultations;Correlative Study;Data;Data Analyses;Data Collection;Data Commons;data curation;Data Element;data management;Data Management Resources;data quality;Data Set;data sharing;Databases;Deposition;design;Development;Enrollment;Ensure;experience;Fostering;Funding;Future;General Population;Goals;Home;Human;immune modulating agents;Immune response;Immunologic Monitoring;Immunologist;Immunology procedure;Immunooncology;Immunotherapeutic agent;Immunotherapy;immunotherapy clinical trials;immunotherapy trials;Infrastructure;innovation;insight;Laboratories;Leadership;Malignant Neoplasms;Medical;meetings;member;Methods;Mission;Monitor;next generation;novel;Oncology;oncology program;operation;outreach;participant enrollment;Patients;Pennsylvania;Performance;Procedures;Process;Production;Productivity;Quality Control;Reagent;Registries;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;research study;Research Support;Resources;Scientist;Secure;Services;Site;skills;sound;Specimen;Technology;tool;translational applications;Translational Research;translational study;Translations;treatment response;trial design;Universities;virtual;web site;Work;working group

PROJECT_TITLE: Advancing the Coordinating Center for the Canine Cancer Immunotherapy Network


NIH_SPENDING_CATS: Cancer

PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward  CHEMICAL SYNTHESIS SHARED RESOURCE - PROJECT NARRATIVE  Per PAR-21-321, a Project Narrative is not required for this Component.  OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PI_NAMEs: SCHRAMM, VERN L. (contact)

PROJECT_TERMS: Address;Alkynes;Analytical Chemistry;Applications Grants;Azides;biological systems;Cancer Center Support Grant;Carbohydrates;catalyst;chemical reaction;chemical synthesis;Chemicals;Chemistry;Client;cold temperature;Collaborations;Communities;Complex;computational chemistry;Consult;Copper;cost estimate;Custom;cycloaddition;Data;design;Development;Eligibility Determination;Equipment;Evaluation;Faculty;Fees;Fluorides;Funding;Goals;Grant;Human Resources;In Vitro;in vivo;Individual;instrumentation;Isotope Labeling;Laboratories;lead optimization;Libraries;Ligands;Malignant Neoplasms;member;microwave electromagnetic radiation;new technology;novel;Peptides;Personnel Staffing;Pharmaceutical Chemistry;pressure;Principal Investigator;Process;programs;Publications;Publishing;Reaction;Reagent;recruit;Research;Research Personnel;Research Project Grants;Research Proposals;Resource Sharing;Resources;Role;Scheme;screening;Screening for cancer;Services;small molecule;sound;Strategic Planning;Structure-Activity Relationship;Sulfur;Techniques;Therapeutic;Validation;virtual screening;Work

PROJECT_TITLE: Chemical Synthesis Shared Resource


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Clinical Research;Comparative Effectiveness Research;Pain Research;Patient Safety;Physical Injury - Accidents and Adverse Effects

ORG_CITY: MINNEAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Arthroscopic-assisted tibial plateau fixation (AATPF) vs. Open reduction internal fixation (ORIF): A multicenter randomized controlled trial Project Narrative The current standard treatment for tibial plateau fracture fixation, open reduction and internal fixation (ORIF), has limitations, including surgical site infections, pain, stiffness, and a prolonged period of non-weight bearing restrictions.1-6 The ultimate goal of this project is to conduct a multicenter randomized controlled trial to test the hypothesis that arthroscopic-assisted tibial plateau fixation (AATPF) provides superior patient-reported outcomes, clinical outcomes, and radiographic outcomes compared to the traditional ORIF method.

PI_NAMEs: NGUYEN, MAI P (contact);SWIONTKOWSKI, MARC F.

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acceleration;adjudication;analog;Articular Range of Motion;Centers for Disease Control and Prevention (U.S.);Classification;Clinical;clinical research site;Collaborations;Committee Members;Complication;cost efficient;Data;data management;design;Dissection;Documentation;Electronics;Eligibility Determination;Enrollment;Ensure;evidence base;Fellowship;follow-up;Fracture;Fracture Fixation;Funding;Future;Goals;Grant;health related quality of life;hospital readmission;Infection;Information Systems;Institutional Review Boards;Interdisciplinary Study;interest;International;Joints;Knee;Knee joint;knee pain;knee replacement arthroplasty;Lateral;Leadership;Level of Evidence;Limb structure;Longevity;Manuals;Measurement;Measures;Methods;minimally invasive;Minnesota;Modeling;Monitor;operation;Operative Surgical Procedures;Orthopedic Surgery;Orthopedics;Outcome;Pain;Participant;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Phase;Postoperative Period;postoperative recovery;Preparation;prescription opioid;preservation;primary outcome;Protocols documentation;radiological imaging;Randomized;Randomized, Controlled Trials;Recording of previous events;Recovery;recruit;Repeat Surgery;Reporting;Research;Research Infrastructure;Research Personnel;Risk;Safety;sample fixation;Sample Size;Secondary to;Site;Societies;soft tissue;Specialist;Sports;standard care;Surface;Surgeon;Surgical complication;surgical risk;Surgical Wound Infection;Testing;Time;timeline;Training;Trauma;Traumatic Arthropathy;trial comparing;Universities;Visual;Visualization;Weight-Bearing state;With laterality;wound

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Immunization;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the development of novel immune interception strategies will decrease cancer incidence among Lynch Syndrome patients. Thus, the proposed research is relevant to the mission of the NIH, particularly the portion pertaining to the pursuit of fundamental knowledge to extend healthy life.

PI_NAMEs: LIPKIN, STEVEN M;VILAR SANCHEZ, EDUARDO  (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Adaptive Immune System;adenoma;Affect;Affinity;Alleles;American;Antigen Presentation;Applications Grants;Aspirin;Autologous;base;Binding;bioinformatics pipeline;Biological Assay;Biological Markers;Catalogs;CD8-Positive T-Lymphocytes;cell killing;cell type;Cell-Mediated Cytolysis;Cells;Chemoprevention;Chemopreventive Agent;Chronic;Clinical;clinical trial implementation;Clinical Trials;Clone Cells;co-clinical trial;Coculture Techniques;cohort;Colorectal;Colorectal Cancer;colorectal cancer prevention;Coupled;Cytometry;cytotoxicity;Development;DNA;Double-Blind Method;Endometrial;Epithelial Cells;exome sequencing;experimental study;Exposure to;familial colorectal cancer;Foundations;Frequencies;gene repair;Genes;genomic data;Genomics;Genotype;Germ-Line Mutation;Goals;Hereditary Malignant Neoplasm;Hereditary Nonpolyposis Colorectal Neoplasms;Image;Immune;Immune response;immunogenic;immunogenicity;Immunologic Monitoring;Immunology;Immunomodulators;Immunoprevention;Immunotherapeutic agent;in silico;Incidence;innovation;insertion/deletion mutation;Knowledge;Lesion;Life;magnetic beads;Malignant Neoplasms;Microsatellite Repeats;Mismatch Repair;Mismatch Repair Deficiency;Mission;mouse model;mRNA sequencing;Mucous Membrane;Mutation;Naproxen;neoantigens;neoplastic cell;Non-Steroidal Anti-Inflammatory Agents;novel;Organoids;Outcome;Ovarian;overexpression;Patients;peptide vaccination;Peptide Vaccines;Peptides;Phase;Phase I Clinical Trials;Phase Ib Clinical Trial;Phase II Clinical Trials;Population;premalignant;prevent;Prevention;Prevention strategy;Prevention trial;Public Health;Randomized;Recurrence;Reporting;Research;Sampling;Screening for cancer;single cell genomics;single-cell RNA sequencing;Small Intestines;Stains;synergism;Systems Biology;T cell receptor repertoire sequencing;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Time;Tissues;tumor;United States National Institutes of Health;Urothelium;Vaccination;vaccination strategy;Validation

PROJECT_TITLE: Cancer Immune-Interception for Lynch Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-J(02)M]


NIH_SPENDING_CATS: Biotechnology;Cancer;Data Science;Networking and Information Technology R&D (NITRD)

PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward  EPIDEMIOLOGY AND CLINICAL RESEARCH INFORMATICS SHARED RESOURCE -  PROJECT NARRATIVE  Per PAR-21-321, a Project Narrative is not required for this Component.  OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PI_NAMEs: ROHAN, THOMAS E (contact)

PROJECT_TERMS: Applications Grants;Big Data Methods;Cancer Center Support Grant;Clinical Data;Clinical Management;Clinical Research;Clinical Trials;cohort;comparative effectiveness;Competence;Complex;complex data;Conduct Clinical Trials;Consultations;Custom;Data;data access;Data Analytics;Data Collection;Data Coordinating Center;data integration;data integrity;data management;data quality;Databases;design;Development;distributed data;Electronic Health Record;Electronics;Ensure;Epidemiology;epidemiology study;experience;Fostering;Grant;Guidelines;Human Resources;improved;Informatics;informatics infrastructure;informatics shared resource;informatics tool;Information Systems;Infrastructure;innovation;Institution;Institutional Review Boards;interdisciplinary collaboration;interoperability;Investigational Drugs;Laboratories;large datasets;Life Cycle Stages;Malignant Neoplasms;Monitor;novel;Occupational activity of managing finances;open source;operation;Operations Research;patient oriented;Patients;Policies;Preventive care;Principal Investigator;Procedures;Process;process improvement;Production;programs;Protocols documentation;Publications;quality assurance;Reporting;repository;Research;Research Personnel;Research Project Grants;research study;Research Training;Resource Informatics;Resource Sharing;Resources;Role;Secure;Security;Services;Site;Software Tools;Source;Standardization;Statistical Data Interpretation;Structure;System;Systems Integration;Time;Training;Work

PROJECT_TITLE: Epidemiology and Clinical Research Informatics Shared Resource


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LAC DU FLAMBEAU

ORG_NAME: GREAT LAKES INTER-TRIBAL COUNCIL, INC.

PHR: NARRATIVE: GLNARCH OVERALL  This Great Lakes Native American Research Centers for Health (GLNARCH) application will pursue exciting opportunities to improve education, training, and research within the Indian Health Service Bemidji Region with increased focus on including Tribal Colleges and Universities (TCU). The Student Career Enhancement Project (SCEP) proposes important activities to expose AI/AN students to remote learning. The Capacity Building Project proposes unique initiatives to better engage TCUs via the established and successful Native American Environmental Health Research (NEHR) network.

PI_NAMEs: CASSIDY, LAURA D;DELLINGER, MATTHEW J;LAVERDURE, ADRIENNE  (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Address;Advisory Committees;Area;artificial intelligence model;career;Communities;COVID-19 pandemic;Data Collection;Databases;Development;digital;Distance Learning;Education;Educational Models;Ensure;Environment;Environmental Health;Evaluation;Evaluation Reports;Event;experience;Exposure to;Facebook;Film;Funding;Funding Mechanisms;Geography;Goals;Great Lakes Region;Health;health application;Health Service Area;higher education;Holistic Health;improved;Indigenous;Institution;interest;Internships;intertribal;Knowledge;Lac du Flambeau;learning strategy;Measures;meetings;Methods;Michigan;Minnesota;Modeling;Modernization;Native American Research Center for Health;Native Americans;Natural Resources;novel;Oral;Outcome;Participant;Persons;Population;Program Evaluation;programs;Research;Research Personnel;Research Support;Reservations;Resource Sharing;Resources;Rural;Science;Scientist;Self Efficacy;skills;Social Distance;social media;student participation;Students;symposium;Technology;Training;Transcend;tribal college;tribal community;Tribal Council;tribal organization;Tribes;United States Indian Health Service;Universities;Update;virtual;webinar;Wisconsin

PROJECT_TITLE: Great Lakes NARCH 11

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y(55)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PHR: Narrative: Administrative Core This Great Lakes Native American Research Centers for Health (GLNARCH) application aligns established partnerships to support health research and AI/AN programs. The Administrative Core is assembled from experienced personnel who have invested in strong working relationships from ongoing NARCH collaborations. This team will coordinate efforts between diverse partners possessing complementary strengths to accomplish GLNARCH aims through efficient use of resources, alignment of common goals, and cultural competence.

PI_NAMEs: LAVERDURE, ADRIENNE  (contact)

PROJECT_TERMS: Administrative Coordination;Advisory Committees;Award;career;Chippewa;Chronic;Collaborations;Communication;Communities;community engagement;cultural competence;Data;Data Collection;data management;Development;digital;Distance Learning;Education;electronic data;Ensure;Environment;Epidemiology;Equity;Evaluation;Event;experience;Family;Fostering;Funding;Geography;global health;Goals;Health;health application;health equity;Health Promotion Sciences;Health Service Area;Human Resources;improved;Indigenous;innovation;intertribal;Investments;Knowledge;Lac du Flambeau;Leadership;learning strategy;Maps;medical schools;meetings;Methods;Modeling;Native American Research Center for Health;Newsletter;novel;Outcome;programs;Qualitative Methods;Reporting;Research;Resources;Role;Science;Students;success;Survey Methodology;System;Telecommunications;Time;Training;tribal college;tribal community;Tribal Council;Tribal group;tribal leader;tribal Nation;Tribes;Turtles;United States Indian Health Service;Universities;Update;Wisconsin;Work

PROJECT_TITLE: GLNARCH 11 Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Heart Disease;Patient Safety

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE One of the most promising strategies to reduce readmissions in heart failure (HF) is through the timely receipt of home health care (HHC) nurse visits and outpatient medical follow-up after discharge, yet our prior observational comparative effectiveness study found that only 12% of Medicare beneficiaries receive these evidence-based practices. Using a Hybrid Type 1 design, this study will test the effectiveness of the I- TRANSFER-HF intervention (early and intensive HHC nurse visits and early outpatient medical follow-up) in a stepped wedge cluster RCT and determine the context surrounding its implementation among a diverse sample of hospitals and HHC agencies. As the first pragmatic trial of HHC in HF, the results have the potential to inform clinical guidelines in home health and improve transitions of care and post-discharge outcomes for HF patients at a national level.

PI_NAMEs: STERLING, MADELINE R (contact)

PROGRAM_OFFICER_NAME: MASTERSON, MARY YAA SEDEGAH

PROJECT_TERMS: Accountability;Acute;Adult;Affect;Ambulatory Care;Area;beneficiary;Care given by nurses;Caring;Certification;Chronic;Clinical;Cluster randomized trial;comparative effectiveness study;Complex;Consolidated Framework for Implementation Research;cost;COVID-19;Data;Discipline of Nursing;Dissemination and Implementation;Effectiveness of Interventions;effectiveness testing;effectiveness/implementation hybrid;effectiveness/implementation trial;Emergency department visit;Equilibrium;evidence base;Evidence based intervention;Evidence based practice;follow-up;Funding;Geography;Goals;Guidelines;Health;Health Care Costs;Healthcare;Healthcare Systems;Heart failure;high risk;Home;Home Care Services;Home Health Agency;Home visitation;hospital care;hospital readmission;Hospitalization;Hospitals;hybrid type 1 design;Hybrids;implementation facilitators;implementation science;improved;improved outcome;innovation;insight;Intervention;Interview;Length of Stay;Medical;Medicare;Medicare claim;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;novel;nursing skill;Observational Study;older adult;Outcome;Outpatients;patient population;Patients;payment;Persons;Phase;Pragmatic clinical trial;pragmatic trial;primary outcome;Process;Process Measure;programs;Protocols documentation;Randomized;randomized trial;readmission rates;Research Priority;response;Role;Sampling;Science;secondary outcome;success;Symptoms;Telemedicine;Testing;Time;treatment as usual;trial design;United States Agency for Healthcare Research and Quality;United States Centers for Medicare and Medicaid Services;virtual;Visit;Visiting Nurse

PROJECT_TITLE: I-TRANSFER-HF: Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe: A Type 1 Hybrid Effectiveness Implementation Trial

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward  FLOW CYTOMETRY SHARED RESOURCE - PROJECT NARRATIVE  Per PAR-21-321, a Project Narrative is not required for this Component.  OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PI_NAMEs: PORCELLI, STEVEN A (contact)

PROJECT_TERMS: Acceleration;advanced analytics;Aerosols;Air;Animal Model;Area;Basic Science;Cancer Biology;Cancer Center Support Grant;Cell Separation;Cells;cohort;Color;Containment;cost effective;Deposition;Development;Educational workshop;Emerging Technologies;Ensure;Equipment;experience;Faculty;Flow Cytometry;Flow Cytometry Shared Resource;Fluorescence;Fluorescence-Activated Cell Sorting;Gene Expression Profiling;Genomics;Goals;Harvest;high dimensionality;high throughput analysis;human model;human subject;Image Analysis;Immunologic Monitoring;improved;Individual;innovation;instrument;instrumentation;Laboratories;Laser Scanning Cytometry;liquid crystal polymer;magnetic beads;Magnetism;Maintenance;Malignant Neoplasms;member;Methods;Microscopic;Mission;nano-string;new technology;novel therapeutics;operation;Outsourcing;Principal Investigator;Procedures;Process;programs;protein profiling;Proteomics;protocol development;Research;Research Activity;research faculty;Research Personnel;Resource Sharing;Resources;RNA;Scanning;Scientist;senior faculty;Services;single cell analysis;Site;Slide;Sorting;Speed;Stream;System;Technical Expertise;Techniques;Technology;technology platform;Tissues;Training;Training Activity;Training Support;Transcript;transcriptomics;Translational Research;translational scientist

PROJECT_TITLE: Flow Cytometry Shared Resource


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Infectious Diseases

ORG_CITY: LUBBOCK

ORG_DEPT: CHEMISTRY

ORG_NAME: TEXAS TECH UNIVERSITY

PHR: The proposed research will enable the development of tools for the characterization of protein carbohydrate structures at a sensitivity, throughput, and level of detail not previously possible. The implementation of these tools will enable researchers to better understand the attributes and biomedical significance of glycans in the development and progression of a wide array of diseases. Examples of future benefits for public health include the identification of disease and cancer biomarkers for medical diagnostics and the monitoring of recombinant protein therapeutics, which will lead to better targeted drugs that are more bioactive with fewer side effects.

PI_NAMEs: MECHREF, YEHIA  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: 2019-nCoV;Address;Adhesions;Algae;Algorithms;Alzheimer's Disease;Anabolism;analytical tool;Area;Bacterial Infections;base;Bioinformatics;bioinformatics tool;Biological;Biological Process;Blood capillaries;cancer biomarkers;carbohydrate structure;Carbon;Cell Differentiation process;Cells;Cirrhosis;Clinical;clinical diagnostics;Code;Communicable Diseases;Communities;Complex;Computer software;computerized data processing;Coronavirus;Coronavirus spike protein;Coupled;COVID-19;Cystic Fibrosis;Development;Diabetes Mellitus;Disease;drug development;Drug Targeting;Fingerprint;Future;Gangliosides;Genes;Glucose;Glycoconjugates;Glycolipids;Glycoproteins;glycosylation;Goals;Heterogeneity;High temperature of physical object;Human Genome;Immune response;implementation tool;improved;indexing;Inflammation;interest;Investigation;ionization;Ions;Isomerism;Isotopes;Kidney Diseases;Label;Libraries;machine learning prediction;Malignant Breast Neoplasm;Malignant neoplasm of esophagus;Malignant neoplasm of liver;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Metabolic Diseases;Metastatic malignant neoplasm to brain;Methods;Monitor;nano;Nature;Oligosaccharides;Outcome;Parkinson Disease;pathogen;Pattern;Polysaccharides;Porosity;Post-Translational Protein Processing;predictive signature;Process;protein complex;Protein Glycosylation;Proteins;Public Health;Reaction;Recombinant Proteins;Research;Research Activity;Research Personnel;Resolution;Role;Running;Sampling;Scientist;side effect;software development;Software Tools;Symbiosis;System;tandem mass spectrometry;Techniques;therapeutic protein;Time;tool;tool development;Traumatic Brain Injury;Variant;Viral;Virion;Virus Diseases

PROJECT_TITLE: Sensitive and Quantitative MS-bases Glycomic Mapping Platform


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PHR: PROJECT NARRATIVE: GLNARCH XI Capacity Building This proposed Capacity Project will develop research capacity at each center (TCU and/or tribal community) as well as coordinate these into a regional network (NEHR). This will fill crucial needs in rural, underfunded AI/AN communities and institutions.

PI_NAMEs: DELLINGER, MATTHEW J (contact)

PROJECT_TERMS: Address;Adoption;Alaska Native;American Indians;Collaborations;Communities;Consultations;Data;Development;Environmental Health;experience;Faculty;Fostering;Foundations;Funding;Funding Opportunities;Goals;Grant;Health;health science research;improved;Indigenous;Individual;innovation;Institution;inter-institutional;interest;Internships;intertribal;Mainstreaming;medical schools;meetings;Mentors;Michigan;Minnesota;Modeling;Native American population;Native American Research Center for Health;Natural Resources;network models;Participant;Process;Program Evaluation;programs;Research;Research Design;Research Personnel;Research Project Grants;Resources;Rural;Site;skills;Students;summer research;System;Time;Translating;tribal college;tribal community;Tribal Council;tribal health;tribal organization;Tribes;Trust;United States Indian Health Service;Universities;university student;webinar;Wisconsin;Work;Writing

PROJECT_TITLE: Enhancing Research Capacity for Tribal Colleges and Rural Native American Populations Through an Indigenized Approach


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Interstitial Cystitis;Neurosciences;Pain Research;Urologic Diseases

ORG_CITY: BURLINGTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: We lack understanding of how structural and functional changes in the micturition reflex are linked to bladder pain syndrome/interstitial cystitis and how stress exacerbates symptoms, thus impeding effective therapies. We hypothesize that increases in urinary frequency and pelvic pain from stress- and injury-induced changes in central and peripheral micturition circuits reflect neuropeptidergic PACAP/PAC1 receptor-mediated signaling and neuroplasticity to engender a pro-excitatory state. We will assess how maladaptive intersections between the PACAP/PAC1R pathways may be contributory to stress-induced urinary bladder dysfunction and pelvic pain.

PI_NAMEs: HAMMACK, SAYAMWONG E.;MAY, VICTOR ;VIZZARD, MARGARET ANN (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Address;Afferent Neurons;Behavior;biological adaptation to stress;Bladder;Bladder Dysfunction;Cell Nucleus;Chronic;chronic pelvic pain;Chronic stress;Clinical;Collaborations;Complex;Control Animal;Cyclophosphamide;Discipline;Distal;effective therapy;Esthesia;FOS gene;Increased frequency of micturition;Inflammation;Injury;innovation;insight;interdisciplinary approach;Interstitial Cystitis;Laboratories;Lateral;Link;Micturition Reflex;Modeling;multidisciplinary;neural circuit;neurochemistry;Neuronal Plasticity;Neurons;Neuropeptides;novel;PACAPR-1 protein;Pain;Pain Disorder;parabrachial nucleus;Pathway interactions;Pattern;Pelvic Pain;Pelvis;Peripheral;Phenotype;pituitary adenylate cyclase activating polypeptide;Pontine structure;Psychological Stress;Publishing;Receptor Signaling;receptor-mediated signaling;Research;response;Role;Sensory;Signal Transduction;Signs and Symptoms;Spinal Cord;Stress;stressor;Structure;Structure of terminal stria nuclei of preoptic region;Symptoms;Testing;urinary;Urination;Work

PROJECT_TITLE: PACAP/PAC1 receptor signaling in micturition neurocircuits: effects of stress and injury/inflammation

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome

PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward  GENOMICS SHARED RESOURCE - PROJECT NARRATIVE  Per PAR-21-321, a Project Narrative is not required for this Component.  OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PI_NAMEs: GREALLY, JOHN  (contact)

PROJECT_TERMS: Back;Biological Assay;Biological Sciences;Biometry;Cancer Center Support Grant;cancer genomics;cancer health disparity;Cancer Patient;Cell Separation;Cell surface;Cells;Cellular Assay;Chromatin;Chromium;Clinical;clinical sequencing;Complement;computing resources;Consultations;Core Facility;cost;cost efficient;Cost Savings;Data;Data Analyses;Data Analytics;data management;Data Storage and Retrieval;Drops;epigenomics;Equipment;Event;exome sequencing;Experimental Designs;experimental study;Fostering;Foundations;Funding;genomic data;Genomics;Genomics Shared Resource;Goals;health disparity;health equity;Hematopoiesis;Human Resources;improved;Individual;innovation;insight;Institution;Institutional Review Boards;Investments;laboratory experience;Malignant Neoplasms;migration;minority patient;Mission;Modeling;Molecular Cytogenetics;neighborhood disadvantage;Outcome;Outsourcing;patient population;Patients;Pattern;Population;precision medicine;Principal Investigator;Process;programs;Protocols documentation;Provider;Reagent;Research;Research Design;Research Personnel;Resource Sharing;Resources;response;Sampling;Services;single cell genomics;single cell sequencing;single-cell RNA sequencing;skills;socioeconomic disadvantage;Somatic Mutation;Techniques;Technology;Tissues;transcriptome sequencing;transcriptomics;tumor;underserved community;underserved minority;Work

PROJECT_TITLE: Genomics Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer

PHR: Program Director/Principal Investigator (Last, First, Middle): Chu, Edward  STRUCTURAL BIOLOGY SHARED RESOURCE - PROJECT NARRATIVE  Per PAR-21-321, a Project Narrative is not required for this Component.  OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page

PI_NAMEs: ALMO, STEVEN C. (contact)

PROJECT_TERMS: Animals;ART protein;Automation;Biological Markers;Biological Process;Cancer Center Support Grant;Cells;computerized data processing;Cryoelectron Microscopy;Data;data acquisition;Data Analyses;Data Collection;design and construction;Disease;disease model;Dissection;experience;Experimental Designs;flexibility;Generations;Infrastructure;Insecta;insight;Label;Laboratories;Lead;Leadership;Light;Mammalian Cell;Mass Spectrum Analysis;member;Molecular;Movement;New York;Nucleic Acids;Pathologic Processes;Pathway interactions;Pharmaceutical Chemistry;Photons;Post-Translational Protein Processing;Preparation;Principal Investigator;Production;programs;Protein Biosynthesis;Protein Engineering;protein expression;Proteins;Proteomics;Research Personnel;Research Project Grants;Resolution;Resource Sharing;Resources;response;Sampling;Science;Services;Source;Strategic Planning;structural biology;Structure;Synchrotrons;Technology;Therapeutic;tool;Treatment Protocols;Validation;X-Ray Crystallography

PROJECT_TITLE: Structural Biology Shared Resource


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Emergency Care;Heart Disease;Pediatric

ORG_CITY: PIKESVILLE

ORG_NAME: CORAM TECHNOLOGIES, INC.

PHR: NARRATIVE – STTR PHASE II Cardiac arrest kills hundreds of thousands of Americans each year, but survival is improved with bystander cardiopulmonary resuscitation (CPR). CPR is required by law to be taught in most U.S. high schools, but instructional methods are outdated, non-standardized, and ineffective. Building on the success of our Phase I prototype, we propose finalizing for commercial production a novel, interactive CPR video game experience that combines the drama of a live-action cardiac arrest film with a "CPR Spring" device, to improve learning of CPR skills that should translate into improved survival from cardiac arrest.

PI_NAMEs: TOFT, LORREL ELIZABETH BROWN (contact)

PROJECT_TERMS: Address;Adolescent;Affect;American;Auditory;Biomedical Engineering;Biometry;Businesses;Canada;Cardiopulmonary Resuscitation;cardiovascular emergency;Cellular Phone;Chest;Collaborations;commercialization;Computer software;Computers;cost;Data;design;Devices;digital;digital media;Drama;Education;Educational process of instructing;Effectiveness;Electronics;Emergency Care;Emotional;experience;Feedback;Female;Film;gender disparity;Goals;Grant;handheld mobile device;Heart Arrest;high school;High School Student;Human;improved;innovation;Instruction;instructor;interest;large scale production;Laws;Learning;Link;Manikins;Marketing;Methods;mobile application;Modernization;multisensory;North America;novel;out-of-hospital cardiac arrest;Outcome;Persons;Phase;Play;Price;Probability;Production;Property;prototype;Psychology;Reporting;response;Schools;sensor;skill acquisition;skills;Small Business Technology Transfer Research;smartphone application;Specific qualifier value;Students;success;System;Tactile;teacher;Teaching Method;Technology;Testing;theories;Time;Training;Translating;transmission process;Update;Video Games;Visual;wireless communication;wireless fidelity;Woman

PROJECT_TITLE: Using Interactive Digital Media to Teach Cardiopulmonary Resuscitation to High School Students


NIH_SPENDING_CATS: Cancer;Genetics;Hematology

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: Project Narrative The DNA methyltransferase DNMT3A, applies methyl groups to DNA and has been found to be necessary for development of the human brain, regulation of body size, control of blood cell differentiation and for leukemia development. A particular form of the enzyme, DNMT3A2, is overexpressed in human cancers and may contribute to the widespread methylation changes found in every cancer. We will test whether this overexpression can initiate cancer, use cryo-EM to determine how it works on chromatin and determine how cells read methylation signals in DNA.

PI_NAMEs: JONES, PETER A (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Address;age related;Binding;Biochemical;Biological;Blood Cells;Body Size;Brain;cancer cell;cancer initiation;Cancer Model;carcinogenesis;Cell Differentiation process;Cell division;cell transformation;Cells;Chemicals;Chromatin;Chromatin Structure;Cryoelectron Microscopy;Development;DNA;DNA Methylation;DNA Modification Methylases;DNMT3a;Embryonic Development;Enzymes;Etiology;flexibility;follow-up;Funding Mechanisms;Genes;Genetic;Hematopoiesis;Human;insight;Knock-out;leukemia;Malignant Neoplasms;methyl group;Methylation;mouse model;Mus;Mutation;Normal Cell;novel;Nucleosomes;overexpression;postnatal development;Prevalence;Process;Protein Isoforms;Proteins;Regulation;Role;Signal Transduction;Solid;Solid Neoplasm;Structure;Testing;transcription factor;virtual;Work

PROJECT_TITLE: Establishing and Interpreting Abnormal DNA Methylation in Cancer


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Cervical Cancer;Clinical Research;Genetics;Human Genome;Precision Medicine;Prevention;Radiation Oncology;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Cervical cancer patients treated with standard of care (SoC) chemoradiation therapy (CRT) commonly experience disease recurrence, and current clinical testing and genomic research data cannot predict which patients will fail therapy or would benefit from personalized treatment. Based on our recent publications integrating genomic and imaging data to improve CRT risk stratification, we intend to stratify patients into groups with distinct mechanisms of resistance and validate precise treatment targets using large multi-omics (transcriptomic, radiomic, proteomic, and metabolomic) and longitudinal data. In this proposal, we will develop new radiogenomic and deep learning approaches to identify novel biomarkers from these high-dimensional and complex data and will experimentally validate these targets in vitro and in patient samples.

PI_NAMEs: ZHANG, JIN  (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: 3-Dimensional;Aftercare;alternative treatment;American;anti-cancer research;Aorta;Biological;Biological Assay;Biological Markers;Biological Models;Biology;biomarker identification;Biopsy;Cancer Biology;Cancer cell line;cancer diagnosis;Cancer Patient;cancer risk;Cell Cycle;Cell division;Cell Respiration;cell type;Cervical;Cervix Neoplasms;Cessation of life;Characteristics;chemoradiation;Chemotherapy and/or radiation;Classification;Clinical;Clinical Data;clinical decision-making;Clinical Treatment;clinically actionable;clinically significant;Cluster Analysis;complex data;crowdsourcing;Data;deep learning;Development;Disease;druggable target;Epithelium;experience;Failure;Gene Expression;Genes;Genetic Markers;genomic data;Genomics;Glycolysis;Grant;high dimensionality;Histology;Human Papilloma Virus Vaccination;Image;improved;improved outcome;In Situ;In Vitro;Incidence;inhibitor;insight;Libraries;Ligands;Local Therapy;Lymph Node Involvement;lymph nodes;Magnetic Resonance Imaging;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mesenchymal;metabolomics;Metastatic/Recurrent;Methods;Modality;Modeling;Molecular;Multiomic Data;multiple omics;Mutate;Nanostructures;Neoplasm Metastasis;Nodal;novel;novel marker;nuclear factor-erythroid 2;Organoids;Outcome;outcome prediction;Oxidative Phosphorylation;palliative;Pathway interactions;patient stratification;Patient-Focused Outcomes;Patients;Pelvis;personalized medicine;Phenotype;Positive Lymph Node;Positron-Emission Tomography;Pre-Clinical Model;predicting response;Prediction of Radiation Response;Prediction of Response to Therapy;predictive marker;predictive modeling;Prognosis;prognostic;Prognostic Marker;prognostic model;programs;Proteins;Proteomics;Publications;Publishing;Quantitative Reverse Transcriptase PCR;Radiation Oncology;Radiogenomics;radiomics;Reaction;Reagent;Recurrence;Recurrent disease;Research;research clinical testing;Resistance;resistance mechanism;Respiration;Risk;risk prediction;risk prediction model;risk stratification;RNA;Sampling;Science;serial imaging;Series;single-cell RNA sequencing;Societies;Staging;standard of care;Stratification;Survival Analysis;Survival Rate;targeted treatment;Testing;The Cancer Genome Atlas;therapy outcome;Time;Tissue Microarray;transcriptome sequencing;transcriptomics;Translations;Treatment Failure;Treatment Protocols;treatment risk;tumor;Tumor Bank;tumor progression;Western Blotting;women's diagnosis;Women's mortality

PROJECT_TITLE: Integrating multi-omics, imaging, and longitudinal data to predict radiation response in cervical cancer

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Narrative The goal of the Boston University Contraceptive Development Research Center is to develop a new woman-controlled on-demand contraception method based on the use of a vaginal film that releases an antisperm monoclonal antibody that prevents sperm from fertilizing the egg. There is an urgent need for more contraception choices as nearly half of all current pregnancies are unplanned. Unplanned pregnancies disproportionately affect young women and contribute to maternal and child mortality and intergenerational cycles of poverty and poor health.

PI_NAMEs: ANDERSON, DEBORAH J (contact);WHALEY, KEVIN

PROGRAM_OFFICER_NAME: LINDSEY, CHRISTOPHER CHARLES

PROJECT_TERMS: Address;Affect;Antibodies;Antigens;Atopobium vaginae;Biological Assay;Boston;CDW52 gene;Cells;Cellular Immunity;cervicovaginal;Cervix Mucus;Child Mortality;Clinical;clinical lot;Clinical Research;Clinical Trials;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;cost effective;Couples;cytokine;Data;Database Management Systems;Databases;design;Developed Countries;Development;Dose;Double-Blind Method;drug testing;efficacy testing;efficacy trial;Endocervix;Engineering;Enrollment;Enzyme-Linked Immunosorbent Assay;Epidemic;Film;Formulation;Funding;Gene Expression;Goals;Good Clinical Practice;Grant;Health;HIV-1;Human;Human Herpesvirus 2;human male;human monoclonal antibodies;human subject;Immobilization;improved;Industrialization;Infection;Infertility;Inflammatory;innovation;intergenerational;irritation;Leadership;male;Manuals;manufacture;manufacturing process;manufacturing scale-up;Maternal Mortality;Measures;medical schools;Methods;microbicide;minimal risk;Monitoring Clinical Trials;Monoclonal Antibodies;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;Nicotiana;operation;Oryctolagus cuniculus;pathogen;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase;Phase I Clinical Trials;Placebo Control;Positioning Attribute;Poverty;preclinical study;Preclinical Testing;prevent;Prevention;programs;Protocols documentation;Randomized;Rattus;Reaction;Regimen;Reproductive Health;reproductive tract;Research;research and development;Research Institute;Research Project Grants;Safety;safety study;Seminal fluid;Sexual Transmission;Single-Blind Study;Site;Specificity;Sperm Agglutination;sperm cell;Sperm Motility;Spermatozoa antibody;stability testing;statistics;Technology;Testing;Texas;Tissues;Toxicology;Training;unintended pregnancy;United States National Institutes of Health;Universities;Vagina;vaginal microbiome;Vaginal Route of Drug Administration;Virginia;Woman;women's clinical trial;young woman;zygote

PROJECT_TITLE: Antibody-based Contraceptive MPTs:  Advancing the Human Contraceptive Antibody (HCA) through Clinical Trials


PI_NAMEs: ANDERSON, DEBORAH J (contact)

PROJECT_TERMS: Achievement;Adherence;Antibodies;Antibody Formation;Antigen Targeting;Atopobium vaginae;Award;Biological;Blood;Boston;Clinical;Clinical Data;clinical database;Clinical Management;Clinical Trials;Clinical Trials Database;Communication;Contraceptive Agents;Contraceptive methods;Data;data acquisition;data management;data sharing;Development;Electronics;Ensure;Environment;experience;Experimental Designs;Film;Funding;Goals;Grant;Guidelines;HIV-1;Human;Human Herpesvirus 2;IgG1;Immobilization;Individual;Industrialization;Industry;Infertility;Infrastructure;innovation;Institution;Leadership;Libraries;Liquid substance;medical schools;meetings;Methods;Monitor;Monoclonal Antibodies;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;Nicotiana;pathogen;Performance;Phase I Clinical Trials;Positioning Attribute;pre-clinical;Preclinical Testing;Prevention;Program Reviews;programs;Publications;Reagent;Research;research and development;Research Personnel;Research Project Grants;Resource Allocation;Safety;Schedule;Scientist;Sexually Transmitted Diseases;Site;Specificity;Sperm Agglutination;sperm cell;Spermatozoa antibody;Statistical Data Interpretation;statistical service;statistics;success;symposium;Technology;Testing;Translational Research;United States National Institutes of Health;Universities;Vagina;Vaginal Route of Drug Administration;web site;Woman

PROJECT_TITLE: Core A:  Administration


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

PI_NAMEs: WHALEY, KEVIN  (contact)

PROJECT_TERMS: Agglutination;Antibodies;Atopobium vaginae;Binding;Cervix Uteri;Clinical;clinical lot;Clinical Research;Clinical Trials;commercialization;Contraceptive Agents;Contraceptive methods;Development;Dose;drug testing;experience;Film;Funding;Glycoproteins;Grant;HIV;HIV-1;Hour;Human;Human Herpesvirus 2;Industrialization;irritation;male;manufacture;manufacturing process;manufacturing scale-up;manufacturing test;Monoclonal Antibodies;Mucous body substance;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;Oryctolagus cuniculus;Pathway interactions;Pharmaceutical Preparations;Phase;phase 2 study;Phase I Clinical Trials;preclinical study;Prevention;programs;Rattus;reproductive tract;research clinical testing;Risk;Safety;Sampling;Sexually Transmitted Diseases;Simplexvirus;sperm cell;Sperm Motility;stability testing;Technology;Testing;Toxicology;Vagina;Woman

PROJECT_TITLE: Project 1:  Industrialization of ZB-06


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Lymphatic Research;Lymphoma;Mental Health;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rehabilitation;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative This study will identify molecular pathways that represent potential targets for interventions to protect AYA survivors against the adverse biological effects of social isolation, socioeconomic disadvantage, and other psychological and social determinants of health in the highly stressful context of cancer. Its intent is to identify functional genomic pathways through which social and psychological factors influence gene regulation and alter health outcomes in AYAs; and, to define the role of such effects in structuring health disparities in post-treatment survivorship.

PI_NAMEs: ZEBRACK, BRADLEY JAY (contact)

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: Address;Adolescence;Adolescent and Young Adult;Adolescent and young adult cancer patients;adolescent health outcomes;Adult Lymphoma;Affect;Aftercare;Age;American College of Radiology Imaging Network;Anti-viral resistance;Biological;Biological Assay;Biology;Blood;Blood specimen;cancer diagnosis;Cancer Model;cancer recurrence;cancer survival;Cancer Survivor;Cancer Survivorship;cancer survivorship care;cancer therapy;Cells;Childhood;childhood adversity;Chronic Disease;Collaborations;Community Clinical Oncology Program;Coping Behavior;Data;Data Set;Development;Discrimination;Disease Progression;Disparity;early childhood;Eastern Cooperative Oncology Group;Endocrine;Environmental Risk Factor;ethnic identity;Ethnic Origin;experience;Exposure to;functional genomics;Future;Gender;Gender Identity;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;genome-wide analysis;genomic profiles;Geographic Locations;Geography;Goals;Health;health disparity;Heterogeneity;Hodgkin Disease;Human;Immune;immune function;improved;Individual;Inflammation;Inflammatory;Interferon Type I;Intervention;Investigation;knowledge base;Late Effects;Life;Literature;Longitudinal cohort study;Malignant Neoplasms;Maps;Meaning and purpose;Measures;Medical;Mental Health;Molecular;Molecular Target;Morbidity - disease rate;mortality;National Cancer Institute;Neoplasm Metastasis;neural;Non-Hodgkin's Lymphoma;novel;Oncology;Outcome;Pathway interactions;Patients;pediatric trauma;perceived discrimination;Personal Satisfaction;physical conditioning;population health;Positioning Attribute;Poverty;Process;programs;Prospective, cohort study;psychologic;Psychological Factors;psychosocial;psychosocial stressors;Quality of life;Race;racial identity;recruit;Reporting;Research;Research Infrastructure;resilience factor;response;Risk;Risk Factors;Risk Reduction;Role;Rural;Self Efficacy;sex;sexual identity;social;Social Conditions;social engagement;Social Environment;social factors;social genomics;social health determinants;Social isolation;Social support;socioeconomic disadvantage;socioeconomics;Structure;Supportive care;Survivors;survivorship;Symptoms;therapy resistant;transcriptome;trauma exposure;treatment effect;Treatment/Psychosocial Effects;tumor progression;Tumor Tissue;Viral Genes;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Social genomic mechanisms of health disparities among Adolescent and Young Adult (AYA) cancer survivors


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Microbiome;Patient Safety;Prevention;Women's Health Research

PI_NAMEs: THURMAN, ANDREA RIES (contact)

PROJECT_TERMS: Adverse event;Antibodies;Atopobium vaginae;Award;Benchmarking;Biological Assay;Blood;Boston;Cells;cervicovaginal;cervicovaginal microbiome;Cervix Mucus;Clinical;Clinical Protocols;Clinical Research;clinical training;Clinical Trials;Coitus;Collaborations;commercialization;Communities;Consent;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;Couples;Data;Data Collection;data management;data sharing;Development;Dose;Double-Blind Method;Drug Kinetics;efficacy testing;efficacy trial;Enrollment;Epithelium;Family Planning;Feedback;Female;Film;first-in-human;Future;Gene Expression;Generations;Genitalia;Good Clinical Practice;Health;Hour;Human;human subject;Hydration status;Immune;Immunity;in vivo;Inflammation;Inflammatory;innovation;Institutional Review Boards;Intervention;Investigational Drugs;Laboratories;laboratory experience;Leadership;Life Style;Liquid substance;Luteinizing Hormone;male;Manuals;Measurement;medical schools;minimal risk;Monitor;Monoclonal Antibodies;Mucous Membrane;National Institute of Child Health and Human Development;operation;Operative Surgical Procedures;Ovulation;Participant;Phase;Placebo Control;Placebos;Positioning Attribute;Procedures;programs;Proteins;Protocols documentation;Randomized;Recommendation;Regulation;Research;Research Design;Safety;safety assessment;safety study;Sampling;Sexual Partners;Signal Transduction;Single-Blind Study;Site;sperm cell;Sperm Motility;Spermatocidal Agents;Spermatozoa antibody;Test Result;Testing;Texas;Time;Tissues;Training;trial design;United States Food and Drug Administration;Universities;Unsafe Sex;urinary;Vagina;vaginal microbiome;Virginia;Visit;Woman

PROJECT_TITLE: Project 2:  Phase 1 and Phase 2a ZB-06 Clinical Studies


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Arthritis;Biotechnology;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Opioids;Osteoarthritis;Pain Research;Peripheral Neuropathy

ORG_CITY: REDWOOD CITY

ORG_NAME: AFASCI, INC.

ORG_STATE: CA

PHR: 8. NARRATIVE Chronic pain affects millions of Americans, yet less than half of patients respond to current treatments, leading to opioid relance and the opioid crisis. AfaSci has discovered a non-opioid, single molecule, dual modulator of the T-type calcium channel, a neuronal pain signaling pathway, and soluble epoxide hydrolase, an enzyme involved in inflammation. This dual modulator can provide complementary analgesia and anti-inflammation, leading to better pain relief with fewer side effects. We now propose advancing our IND AFA-281, to first-in- human clinical studies for the treatment of chronic neuropathic pain.

PI_NAMEs: XIE, XINMIN SIMON (contact)

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Absence Epilepsy;Absence of pain sensation;Address;Affect;allodynia;American;Analgesics;animal efficacy;Animal Model;Animals;Anti-Inflammatory Agents;Antiinflammatory Effect;Biological;Biological Assay;Biological Availability;Brain;Businesses;Calcium Channel;Canis familiaris;capsule;Cardiac;Cardiac Myocytes;Cardiotoxicity;chemotherapy;chronic neuropathic pain;chronic pain;Clinical;clinical investigation;Clinical Research;Clinical Trials;cohort;cost;Data;Degenerative polyarthritis;Development;Diabetes Mellitus;Dose;Dose Limiting;Double-Blind Method;Drug Design;Drug Interactions;Drug Kinetics;Drug Targeting;Economic Burden;Electrocardiogram;Electroencephalography;Electromyography;Electrophysiology (science);Enzymes;Epoxide hydrolase;experience;Fatty Acids;first-in-human;gabapentin;gain of function mutation;Genes;genotoxicity;Glycols;Half-Life;healthy volunteer;Heart Diseases;Human;Hyperalgesia;improved;in vivo;Inflammation;Inflammation Mediators;Inflammatory;inflammatory pain;inhibitor;innovation;Ion Channel;Irritable Bowel Syndrome;knockout gene;Ligand Binding;Malignant Neoplasms;manufacture;Maximum Tolerated Dose;Measures;medication nonadherence;Microglia;National Institute of Neurological Disorders and Stroke;nerve injury;Nervous System;Neurons;Neuropathy;new chemical entity;non-opioid analgesic;Opioid;opioid epidemic;opioid mortality;Oral;osteoarthritis pain;Pain;Pain management;pain model;pain relief;pain signal;painful neuropathy;Pathway interactions;Patients;pediatric patients;Peripheral;Peripheral Nerves;Persistent pain;Pharmaceutical Preparations;Pharmacology;Phase;Phase I Clinical Trials;phase I trial;phase II trial;Phenotype;pill;placebo controlled study;Plasma;Polypharmacy;pregabalin;Progress Reports;Rattus;Reporting;response;Rodent;Safety;screening;Sensory;side effect;Signal Pathway;single molecule;small molecule;social;spared nerve;Spinal Cord;Spinal Ganglia;success;T-Type Calcium Channels;targeted biomarker;Testing;Therapeutic;tissue injury;Tissues;Touch sensation;Toxic effect;Up-Regulation;Visceral pain

PROJECT_TITLE: Clinical Phase I trials on an IND single molecule dual inhibitor of Cav3 channels and soluble epoxide hydrolase for treatment of neuropathic pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-S(14)B]


PROJECT_TERMS: Antibodies;Atopobium vaginae;Biological Assay;Blood;Boston;CCR5 gene;Cells;Cellular Immunity;Clinical;Clinical Trials;commercialization;Conduct Clinical Trials;Contraceptive Agents;Contraceptive methods;cytokine;Data;design;Development;Dose;Enrollment;Enzyme-Linked Immunosorbent Assay;Epithelium;experimental study;Film;Formulation;Gene Expression;Generations;Health;Human;Immunity;improved;Inflammation;Inflammatory;inflammatory marker;innovation;Intravaginal Administration;Laboratories;Laboratory Study;manufacture;Marketing;Measures;Monoclonal Antibodies;pathogen;Pathway interactions;Patient Preferences;pharmacokinetics and pharmacodynamics;Phase;Phase I/II Clinical Trial;Production;Reporting;research and development;Research Institute;Research Project Grants;Safety;safety study;Sampling;sexual HIV transmission;Sperm Agglutination;sperm cell;Spermatozoa antibody;Surveys;System;Technology Transfer;Testing;Time;Universities;Vagina;vaginal microbiome;vaginal microbiota;Woman;women's clinical trial;Work

PROJECT_TITLE: Project 3:  Film Formulation, PK/PD and Safety Studies of ZB-06


ORG_CITY: DALLAS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Mutations in the NGLY1 gene are associated with a rare congenital disorder leading to global developmental delay and neurological inflammation. Studies proposed here will reveal important understand of mitochondrial biology and immunology in the brain, which should benefit not only the NGLY1 disease but also other more complex neurodegenerative diseases that are affecting millions of people.

PI_NAMEs: YAN, NAN  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Affect;Amyotrophic Lateral Sclerosis;Bacteria;Behavior;Biochemical;Biology;Brain;brain cell;cell type;Cells;Cerebellum;Chronic;Complex;Congenital Disorders;Cre driver;Cytoplasm;Cytosol;Data;Defect;Dependence;Deterioration;Development;Disease;DNA;early childhood;early onset;Embryo;Exhibits;Extravasation;Genes;Genetic;Germ Lines;Gliosis;global developmental delay;Goals;Human;Immune;Immune signaling;Immunology;In Situ;induced pluripotent stem cell;Inflammation;inhibitor;Interferons;Internal Ribosome Entry Site;Knock-out;Knockout Mice;Learning;Mediating;Mendelian disorder;Microcephaly;Mitochondria;Mitochondrial DNA;Modeling;Molecular;mortality;Motor;mouse model;mRNA Expression;Mus;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;Neurologic;neuron loss;Neurons;neuropathology;Online Mendelian Inheritance In Man;Parkinson Disease;Pathology;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Purkinje Cells;Rattus;Reporter;response;Role;Seizures;Signal Pathway;Signal Transduction;single cell analysis;single-cell RNA sequencing;Specificity;Stimulator of Interferon Genes;Stress;targeted treatment;Technology;Therapeutic;Time

PROJECT_TITLE: The Mitochondrion-STING Axis in An Early Childhood Onset Neurodegenerative Disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Early detection of neurocognitive disorders is highly beneficial for patients and families, yet cognitive impairment and dementia are frequently under-recognized. The UCSF Brain Health Assessment is a promising paradigm to rapidly detect cognitive impairment and provide turnkey guidance for follow-up. The proposed research will evaluate the effectiveness of the paradigm for improving brain health care via a large pragmatic trial, address challenges to implementation, and pioneer precision medicine approaches to reference group adjustments.

PI_NAMEs: POSSIN, KATHERINE LAUREL (contact)

PROGRAM_OFFICER_NAME: HOMMER, REBECCA EVE

PROJECT_TERMS: Address;African American;Aging;Algorithms;Alzheimer's Disease;Asian;Behavioral Symptoms;Black race;brain health;California;care outcomes;Caring;Classification;Cluster randomized trial;Cognitive;cognitive testing;cohort;Communities;comorbidity;comparison group;Consultations;cost;Dementia;design;Detection;Diagnosis;diagnosis standard;Diagnostic;Disclosure;Early Diagnosis;Economics;education resources;effectiveness evaluation;Epidemiology;ethnic disparity;ethnic diversity;ethnic minority;experience;Family;follow-up;Frequencies;functional decline;Funding;Future;Goals;health assessment;health care disparity;health disparity;health disparity populations;health equity;Healthcare;Hispanic;human old age (65+);Impaired cognition;Impairment;implementation barriers;implementation science;implementation strategy;improved;informant;Integrated Health Care Systems;Language;Latino;Limited English Proficiency;Medical;medical specialties;Medicare;member;Memory;neighborhood disadvantage;neurocognitive disorder;Neuropsychology;novel;novel strategies;Nurses;older adult;Outcome;Pacific Islander;Pathway interactions;Patients;payment;Penetration;Persons;Population;Population Heterogeneity;pragmatic trial;precision medicine;Primary Care;primary care clinic;primary outcome;Provider;racial disparity;racial minority;Randomized;rapid detection;Research;Resources;Risk Adjustment;San Francisco;skills;Social Adjustment;social determinants;social health determinants;Spanish/English;Specialist;Specificity;Standardization;statistics;Surveys;Tablet Computer;Tablets;telehealth;Testing;Time;treatment as usual;treatment effect;Universities;user-friendly;Visuospatial;Work

PROJECT_TITLE: A Pragmatic Trial of the UCSF Brain Health Assessment for the Detection of Cognitive Impairment in Primary Care


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Infectious Diseases

ORG_CITY: BLACKSBURG

ORG_NAME: QENTOROS, LLC

ORG_STATE: VA

PHR: PROJECT NARRATIVE This proposal aims to develop a novel platelet-rich plasma derived biologic named BIO-PLY™ for the treatment of biofilm-related periprosthetic joint infections. The goal of this proposal is to generate the key data necessary to advance this therapeutic toward a Phase II pre-clinical study and an Investigational New Drug (IND) application with the Federal Drug Administration.

PI_NAMEs: GILBERTIE, JESSICA  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Aftercare;aggressive therapy;Amputation;Animal Model;Anti-Bacterial Agents;Anti-Inflammatory Agents;Antibiotics;antimicrobial;Autologous;Bacteria;Biological;Blood Platelets;Cartilage;Chronic;chronic infection;clinical efficacy;Clinical Trials;Communities;Complication;cost;Data;Death Rate;Debridement;Degenerative polyarthritis;Development;Donor Selection;efficacy evaluation;efficacy testing;efficacy validation;Ensure;Equus caballus;Extracellular Matrix;Femur;Goals;good laboratory practice;healing;Health Care Costs;Human;Human Activities;immunogenicity;Impairment;Implant;implant material;improved;In Vitro;in vivo;in vivo Model;Infection;Inflammation;Innate Immune Response;innovation;Investigational New Drug Application;joint infection;Joints;Literature;manufacture;Microbial Biofilms;Modeling;Morbidity - disease rate;Musculoskeletal;Names;novel;novel therapeutics;Operative Surgical Procedures;Orthopedics;Oryctolagus cuniculus;Patients;Periprosthetic joint infection;Pharmaceutical Preparations;Phase;Plasma;Population;porcine model;pre-clinical;preclinical study;Procedures;programs;Property;Refractory;Replacement Arthroplasty;Reporting;Safety;standard of care;Staphylococcus aureus;Staphylococcus aureus infection;Stifle joint;success;Synovial Fluid;T-Lymphocyte;Techniques;Testing;Therapeutic;Tissues;Treatment Failure;Whole Blood;Work

PROJECT_TITLE: A novel therapeutic for the treatment of biofilms in periprosthetic joint infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]


ORG_CITY: ANCHORAGE

ORG_NAME: SOUTHCENTRAL FOUNDATION

ORG_STATE: AK

PHR: PROJECT NARRATIVE - Overall Chronic conditions such as cardiovascular disease and diabetes among Alaska Native and American Indian (ANAI) people are high or on the rise and rates of tobacco use and dependence far exceed national averages. In this project, we will build the capacity of an ANAI run healthcare organization to conduct research which examines the implementation of interventions to improve ANAI health outcomes. Interventions will identify ANAIs with diabetes or pre-diabetes in dental clinics and refer to primary care, match tobacco cessation medications based on the variability in metabolism of nicotine, and encourage use of advanced care planning.

PI_NAMEs: BEANS, JULIE  (contact)

PROJECT_TERMS: acceptability and feasibility;Administrator;Advance Care Planning;Alaska;Alaska Native;Alaska Native population;American Indian community;American Indian Population;American Indians;Area;Arkansas;Award;bean;beneficiary;Biological Markers;Biomedical Research;Cardiovascular Diseases;career;Career Choice;Caring;Charge;Chronic;chronic liver disease;Clinic;Communication;Consolidated Framework for Implementation Research;Consultations;Data;Death Rate;Dental Clinics;design;Diabetes Mellitus;diabetes risk;Dissemination and Implementation;effective intervention;Effectiveness;effectiveness evaluation;effectiveness/implementation design;ethical, legal, and social implication;Evaluation;evidence base;Evidence based intervention;Expenditure;experience;Faculty;Foundations;Funding;Genetic Research;Government;Grant;Health;health care delivery;health care service;health care service organization;health care settings;health organization;Health Services;Healthcare;Healthcare Systems;Heart Diseases;implementation framework;implementation intervention;implementation outcomes;implementation research;improved;Incidence;Intervention;intervention refinement;Intervention Studies;Inupiat;Investigation;Knowledge;Lead;Life Expectancy;Malignant Neoplasms;Medicaid;Medical;Medicare;Mentors;Metabolism;Native American Research Center for Health;Nicotine;Not Hispanic or Latino;Outcome;Palliative Care;Patients;Pharmaceutical Preparations;Population;Prediabetes syndrome;Primary Care;primary care services;Program Evaluation;programs;Psychologist;Reach, Effectiveness, Adoption, Implementation, and Maintenance;referral services;Research;Research Design;Research Personnel;Research Project Grants;Role;Running;Science;screening services;Service delivery model;skills;skills training;smoking cessation;Smoking Cessation Intervention;Students;success;Testing;Tobacco;Tobacco Dependence;Tobacco use;Tobacco Use Cessation;Training;Translational Research;tribal health;tribal healthcare;tribal member;tribal organization;Tribes;Trust;Universities;Washington;Writing

PROJECT_TITLE: Building Capacity for Dissemination and Implementation Research in a Tribal Healthcare System


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Address;Administrator;Alaska;Alaska Native;Alaska Native population;American Indian Population;American Indians;Award;Bioethics;Biomedical Research;career;Career Choice;Collaborations;Communication;Communities;community academic partnership;Complex;Computer software;Consolidated Framework for Implementation Research;Data;Development;Dissemination and Implementation;distrust;Educational Curriculum;Ensure;Eskimo Population;Ethics;Evaluation;Evaluation Research;Fostering;Foundations;Funding;Funding Mechanisms;Goals;Grant;Growth;Health;health care delivery;health care service organization;Health system;Healthcare Systems;implementation design;implementation framework;implementation research;improved;Individual;Infrastructure;Institution;Inupiat;Lead;Leadership;Learning;Mentors;Mentorship;Movement;Native American Research Center for Health;Outcome;Outcomes Research;Persons;Pharmacogenetics;Positioning Attribute;Procedures;Process;Productivity;Program Evaluation;programs;Psychologist;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Personnel;Research Project Grants;Self Determination;Strategic Planning;success;System;Tobacco;Training;tribal community;tribal health;tribal healthcare;Tribes;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Peripheral Neuropathy

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE This multi-PI collaborative proposal directly addresses the specifications delineated by the FOA RFA-EY-004: Ocular Surface Innervation from Cell Types to Circuit Functions, where collectively, the aims will characterize the sensory afferents that innervate the ocular surface on all three levels requested by the FOA, morphologic, molecular, and functional, with rigor and precision. The project will implement cutting -edge genetic mouse models, advanced microscopy, single cell genomic, and machine learning ap proaches, and leverage the expertise of a preexisting, strong interdisciplinary team with a robust productivity record. Data generated from this proposal will provide an extensive, detailed resource to inform the physiology and pathophysiology of the corneal nerve afferents and inform the development of new treatments for diseases, such as dry eye disease, neurotrophic keratitis, and neuropathic ocular pain.

PI_NAMEs: LEE, VIVIAN ;LUO, WENQIN ;ROMPOLAS, PANTELEIMON  (contact);WU, HAO

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Address;Affective;afferent nerve;Afferent Neurons;Alkaline Phosphatase;Anatomy;Axon;Behavior;Behavioral;behavioral response;Biology;Blinking;Brain Stem;calcium indicator;cell type;Cells;Central Nervous System;Computer Analysis;Cornea;Corneal Diseases;corneal epithelium;Cre lox recombination system;Data;Data Analyses;Data Set;Databases;density;Development;Disease;disease model;Dose;Dry Eye Syndromes;Epigenetic Process;epigenomics;Epithelial Cells;Epithelium;Esthesia;experimental study;Eye;Eye diseases;Foundations;Functional disorder;functional group;functional plasticity;Future;ganglion cell;Gene Expression;Gene Expression Profile;Genetic;Genetic Markers;Genetic Models;Genetic Transcription;Goals;Growth Factor;Health;Image;imaging approach;imaging modality;in vivo calcium imaging;Individual;individual variation;inducible Cre;Infection;innovation;insight;intravital imaging;Knowledge;Label;Machine Learning;Measures;Mediating;Metabolic;Microscopy;Molecular;Molecular Profiling;molecular sequence database;Morphology;mouse genetics;mouse model;multiple omics;Mus;Natural regeneration;Nerve;Nerve Fibers;nerve supply;Neurons;Neuropathy;neurophysiology;Neurotrophic Keratitis;novel;ocular pain;ocular surface;ocular surface disease;Operative Surgical Procedures;Pain;painful neuropathy;parabrachial nucleus;Pathologic;Pathology;Peripheral;Physiological;Physiology;Play;Population;Productivity;Property;Quality of life;Recording of previous events;Reflex action;Regulation;Research Personnel;Resources;response;Risk;Role;Sensory;Sensory Nerve Endings;sensory stimulus;single cell genomics;single-cell RNA sequencing;somatosensory;Specific qualifier value;Speed;Spinal Cord;Stimulus;Structure;Structure of trigeminal ganglion;System;Tamoxifen;Therapeutic;Therapeutic Intervention;Time;Tissues;Topical application;transcriptomics;Transgenic Mice;Trauma;Trigeminal nerve structure;Vision;Visual;Visualization;wound healing

PROJECT_TITLE: Underpinnings of corneal innervation: anatomical, molecular, and functional studies of corneal sensory afferents in physiologic and pathologic states


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Academic Training;Address;Adopted;aged;Alaska Native;American Indian community;American Indian Population;American Indians;Applied Research;Area;care outcomes;care systems;career;Case Study;case-based;Clinical;Clinical Research;Collaborations;college;Communities;community based participatory research;Competence;culturally appropriate intervention;design;Development;Dissemination and Implementation;Doctor's Degree;Education;effective intervention;Effectiveness;Ensure;Equipment and supply inventories;Ethics;Evaluation;evidence base;experience;Feedback;Fostering;Foundations;Funding;Goals;hands-on learning;Health;health care delivery;health care service organization;health disparity;Health Priorities;Health Services;Health system;Healthcare Systems;high school;implementation efforts;implementation framework;implementation research;improved;Instruction;Intervention Studies;Investigation;Job Application;Knowledge;Lead;Leadership;Learning;Manuscripts;Master of Science;member;Mentors;Mentorship;multidisciplinary;Native American Research Center for Health;Occupations;Outcome;peer coaching;Persons;Policies;population health;Preparation;Principal Investigator;Problem Solving;professor;programs;Publications;Research;Research Design;Research Personnel;Research Project Grants;Resources;Self Efficacy;Service delivery model;skill acquisition;skills;skills training;sound;Specialist;Statistical Methods;Students;Targeted Research;Training;tribal community;tribal health;tribal healthcare;tribal leader;Tribes;United States;Universities;Washington;Youth

PROJECT_TITLE: Researcher Career Enhancement Project