NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Heart disease remains a major health problem worldwide. This study will address the importance of a novel protein post-translational modification in the maintenance of heart function under resting and stressed conditions, and will investigate how this modification regulates the function of mitochondria, whose dysfunction is implicated in cardiac and other diseases. This research will also produce broadly applicable, basic biological insights.

PI_NAMEs: SU, HUABO  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Address;Adult;Adverse event;Animal Model;Attenuated;Biochemical;Bioenergetics;Biological;Biological Assay;Cancer Patient;cancer therapy;Cardiac;Cardiac health;Cardiac Myocytes;cardiogenesis;Cardiomyopathies;Cardiotoxicity;Cell Death;Cell Physiology;Cells;Cessation of life;Clinical Trials;combat;conditional knockout;Congestive Heart Failure;Cullin Proteins;Data;Development;Dilated Cardiomyopathy;Disease;Enzymes;Equilibrium;Functional disorder;Funding;Goals;Grant;Guanosine Triphosphate Phosphohydrolases;Health;Heart;Heart Diseases;Heart failure;heart function;Homeostasis;Human;Impairment;inhibitor;innovation;insight;Investigation;ISG15 gene;Laboratories;Ligase;live cell imaging;Maintenance;Mediating;Membrane Potentials;Mitochondria;mitochondrial dysfunction;mitochondrial fitness;mitochondrial membrane;Modification;Molecular;Morphology;Mus;Myocardial dysfunction;Neonatal;Non-compaction cardiomyopathy;novel;Oncology;Organ;organ growth;Parkin;Pathologic;Pathology;Pathway interactions;Patients;Performance;Perinatal mortality demographics;Personal Satisfaction;pharmacologic;Phenotype;Physiology;Play;Post-Translational Protein Processing;postmitotic;pre-clinical;premature;pressure;Proteins;Proteome;proteostasis;Publishing;Quality Control;Regenerative capacity;Regulation;Research;Respiration;Rest;restoration;Role;Stress;Testing;Time;Tissues;Ubiquitin;ubiquitin ligase;Ubiquitination;Ventricular

PROJECT_TITLE: Neddylation and cardiac protein quality control

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE As a developing infant’s brain grows, neural stem cells must undergo rapid growth and division. Some children are born with genetic mutations that interfere with this process, leading to reduced brain size and lifelong intellectual disability. Our study aims to understand why these genetic changes lead to disease so that therapeutic approaches can be identified.

PI_NAMEs: RYAN, CHARLES WILLIAM (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: 3-Dimensional;Accounting;Affect;Alleles;Apoptosis;Apoptotic;Binding;Binding Sites;BMI1 gene;Brain;brain size;career;Catalysis;catalyst;Cell Cycle;cell type;Cerebrum;Child;Chromatin;clinically relevant;Compensation;Complement;Complex;crosslink;Data;Databases;Defect;Deposition;Developed Countries;Development;developmental disease;Disease;DNA Damage;DNA Repair;DNA replication fork;DNA Sequence Alteration;Dominant-Negative Mutation;Double Strand Break Repair;early onset;Environment;experimental study;functional restoration;Future;Gene Expression;gene repression;Gene Silencing;Genes;Genetic;genetic testing;Genetic Transcription;genome integrity;genome sequencing;genome-wide;Goals;Growth;Histone H2A;Histones;Human;human embryonic stem cell;human embryonic stem cell line;Individual;Infant;insight;Intellectual functioning disability;Ionizing radiation;Knock-out;Knowledge;Lead;Learning;Light;Literature;Lymphocyte;Mediating;Medical Genetics;Microcephaly;Mitotic;Modeling;Molecular;Monoubiquitination;mouse model;mutant;Mutation;nerve stem cell;neural;Neurodevelopmental Disorder;Neurons;novel;Nucleosomes;Organoids;Pathogenesis;Pathogenicity;Patients;Physicians;Population;Post-Translational Protein Processing;postmitotic;PRC1 Protein;premature;prevent;Process;Proliferating;Prosencephalon;Proteins;rapid growth;repaired;Reporting;Resolution;Response Elements;Role;Schizophrenia;Scientist;Site;targeted treatment;Testing;Therapeutic;Training;Transcriptional Regulation;trend;ubiquitin-protein ligase;Ubiquitination;Variant;whole genome

PROJECT_TITLE: PRC1-dependent H2A Monoubiquitination During Human Corticogenesis


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orthopoxviruses;Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE: The proposed research is relevant to public health because it develops a novel exper- imental model of horizontal gene transmission in poxviruses. Horizontal gene transmission is a critical mecha- nism for the evolution of large DNA viruses to evade the immune response of their hosts, yet currently it can only be studied by indirect sequencing-based approaches. This project is relevant to the NIH’s mission because it opens new avenues of research to experimentally test this critical evolutionary pathway and understand how infectious disease-causing viruses acquire host genes to manipulate the immune response.

PI_NAMEs: ROTHENBURG, STEFAN  (contact)

PROGRAM_OFFICER_NAME: KNISELY, JANE M

PROJECT_TERMS: Address;antagonist;Anti-Inflammatory Agents;Architecture;Bioinformatics;Biological Models;Cell Culture Techniques;Cell Line;Cells;Chromosome Mapping;co-infection;Communicable Diseases;Complement;cytokine;Data;deep sequencing;DNA;DNA Viruses;Elements;Essential Genes;Event;Evolution;Experimental Models;Family;fitness;Fluorescence Microscopy;Frequencies;Gene Transfer;Genes;Genetic Recombination;Genome;Genomics;Goals;Helper Viruses;Herpesviridae;Horizontal Disease Transmission;Horizontal Gene Transfer;Immune Evasion;Immune response;Immune system;In Vitro;in vivo;Infection;integration site;Interleukin-10;Kinetics;Knowledge;Laboratories;Length;Location;Maps;Mediating;Mission;Modeling;Molecular;Mus;novel;Nuclear;Nucleotides;Orthologous Gene;Outcome;Pathway interactions;Phylogenetic Analysis;Play;Poxviridae;pressure;Process;Public Health;Research;Retrotransposon;Retroviridae;RNA;Role;Serial Passage;site-specific integration;System;Techniques;Testing;Time;Transfection;Transgenes;Transgenic Mice;transmission process;United States National Institutes of Health;Vaccinia virus;Viral;Virus;Virus Integration;Virus Replication

PROJECT_TITLE: Molecular mechanisms and ramifications of horizontal gene transfer into poxviruses

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Social Determinants of Health

ORG_CITY: Newark

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Mental illness stigma is a substantial barrier to recognizing and treating depression and anxiety among emerging adults, who are at greater risk of depression and anxiety and are more vulnerable to stigma than people of other age groups. Understanding how mental illness stigma develops, evolves, and impacts treatment outcomes during emerging adulthood can inform the tailoring of interventions to address stigma with greater efficacy. Findings from this three-year longitudinal study of emerging adults will inform the ideal timing of stigma interventions among emerging adults, identify which emerging adults are most vulnerable to the impact of stigma, which stigma mechanisms should be targeted in interventions, and how to combine stigma-reduction tools for subgroups of emerging adults.

PI_NAMEs: EARNSHAW, VALERIE ANN (contact);FOX, ANNIE BETH

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: Address;Adult;Age;age group;aged;Anxiety;anxiety symptoms;Area;barrier to care;Biological;Cardiovascular Diseases;care seeking;Cessation of life;Characteristics;Chronic;Cognitive;community advisory board;COVID-19 pandemic;Data;depressive symptoms;Development;Diabetes Mellitus;Discrimination;emerging adult;emerging adulthood;Epidemiology;evidence base;experience;Goals;Health;Health Services Accessibility;Healthcare;implementation intervention;improved;Individual;individualized medicine;innovation;internalized stigma;Intervention;Lead;Link;longitudinal design;Longitudinal Studies;Mental Depression;Mental disorders;Mental Health;Mental Health Services;model design;multilevel analysis;National Institute of Child Health and Human Development;National Institute of Mental Health;Onset of illness;Participant;Pathway interactions;Pattern;Personal Satisfaction;Persons;physical conditioning;precision medicine;premature;Qualifying;reduce symptoms;Research;Research Personnel;resilience;Resources;response;Risk;Risk Factors;Role;Sampling;Scientist;social;Social Change;social stigma;Stereotyping;structural determinants;Subgroup;Substance Use Disorder;Surveys;Testing;theories;Time;tool;transition to adulthood;Treatment outcome

PROJECT_TITLE: Pathways to mental health care: Examining the longitudinal impact of stigma mechanisms on treatment engagement in emerging adults

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Understanding the mechanisms contributing to pathological inflammation during malaria and the processes that govern the control of malaria parasites within the host can provide insight for the development of adjunctive therapies against this deadly infection. Using human samples and relevant model systems, we will investigate the interactions between multiple stages of the Plasmodium parasite and p53 pathways within relevant host tissues and how such interactions impact malaria pathogenesis and infection biology. Results from this study will provide mechanistic insight into the role of p53 in modulating malaria-induced pathogenesis and liver-stage infection, which may identify druggable targets for interventions aimed at mitigating malaria disease severity and/or liver-stage prophylaxis.

PI_NAMEs: TRAN, TUAN MANH (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;Adjuvant Therapy;Affect;African;Anopheles Genus;Area;Biological Models;Biology;Bite;Blood;Blood Circulation;Blood specimen;Cells;Cerebral Malaria;Cessation of life;Child;Chronic;Culicidae;cytokine;Development;Disease;druggable target;Endothelial Cells;Endothelium;Falciparum Malaria;Fever;global health;Goals;Hepatocyte;Human;humanized mouse;Immune;Immune response;In Vitro;in vitro Model;Individual;Infection;Infection prevention;Inflammation;Inflammatory;insight;Intervention;Investigation;Liver;Malaria;malaria infection;malaria transmission;Mediating;migration;Modeling;Molecular;monocyte;mortality;mouse model;Mus;Outcome;Parasite Control;Parasitemia;Parasites;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Persons;Plasma;Plasmodium;Plasmodium falciparum;prevent;Process;Production;Prophylactic treatment;Prospective, cohort study;Ramp;Recurrence;Regulation;response;Role;Sampling;Seasons;Severity of illness;Signal Pathway;Sporozoites;Stimulus;superinfection;System;Testing;Therapeutic Intervention;Tissues;TP53 gene;transmission process;Vascular Endothelium;Work

PROJECT_TITLE: Evaluating the role of P53 pathways in malaria

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Lung

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE  Bitter taste receptors are expressed in many cell types beyond the tongue, including on immune cells called macrophages that patrol the airways and other tissues in the body. Stimulation of these receptors enhances macrophage uptake of bacteria and may reduce their inflammatory responses. Our goal is to understand the function of these taste receptors in macrophages so we can determine how to best leverage them to combat respiratory infections and reduce inflammation in airway diseases like chronic rhinosinusitis.

PI_NAMEs: ADAPPA, NITHIN ;LEE, ROBERT J. (contact);PALMER, JAMES

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Acute;acute rhinosinusitis;Affect;Agonist;Airway Disease;airway epithelium;airway inflammation;Anosmia;Anti-Bacterial Agents;Anti-Inflammatory Agents;anti-microbial peptide;Antibiotic Resistance;Antibiotics;Asthma;Bacteria;bactericide;Biochemical;Biochemistry;Biological Assay;Biosensor;Blood Component Removal;Calcium;cell type;Cells;cGMP production;chronic rhinosinusitis;Clinical;Clinical Data;combat;cytokine;Data;Defensins;Detection;Disease;disease model;disease phenotype;Disease Progression;Dysosmia;Endothelium;Enzyme-Linked Immunosorbent Assay;eosinophil;Epithelial Cells;experimental study;Family;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic Polymorphism;genotyped patients;Goals;Gram-Negative Bacteria;Human;hyposmia;Immune;immune function;Immune response;Immunologic Receptors;Immunologics;In Vitro;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;Interleukin-4;Invaded;Link;live cell imaging;Macrophage;Macrophage Activation;Malignant Neoplasms;Measurement;microorganism;Molecular;monocyte;Mus;Nasal Polyps;Natural Immunity;Neurons;neutrophil;Neutrophil Infiltration;NF-kappa B;Nitric Oxide;Nitric Oxide Synthase;Nose;novel;Operative Surgical Procedures;opportunistic pathogen;pathogen;Pathway interactions;Patient-Focused Outcomes;Patients;Phagocytosis;Phenotype;Physiology;Polyps;Population;Predisposition;Premature Labor;pressure;Production;Pseudomonas aeruginosa;quorum sensing;receptor;Receptor Cross-Talk;Receptor Signaling;Residual state;Respiratory Disease;Respiratory Tract Infections;response;Role;Sensory;Sentinel;Serum;Signal Pathway;Signal Transduction;Sinus;T2R taste receptors;Taste Buds;Taste Perception;Testing;therapeutic target;Time;Tissues;Toll-Like Receptor Pathway;Toll-like receptors;Tongue;Upper Respiratory Infections;uptake;Work

PROJECT_TITLE: Immune function of bitter taste receptors in human macrophages

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_NAME: MONELL CHEMICAL SENSES CENTER

PHR: PROJECT NARRATIVE Individuals who suffer from a diminished or lost sense of smell (Hyposmia/Anosmia) self-report compensating for the resulting lack of flavor and palatability of foods by adding more salt and self-report preferences for saltier foods. Despite the positive association between salt intake and cardiovascular disease, salt intake and preferences have not been assessed using validated measures in H/A individuals, and there is little guidance on how to improve diet quality in these individuals. This project aims to assess salt taste preferences and intake, as well as appetite in H/A compared with normosmic (i.e. a normal sense of smell) individuals, and to determine if capsaicin can help avoid excess salt use.

PI_NAMEs: HUNTER, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acute;American;Anosmia;Area;Capsaicin;Cardiovascular Diseases;cardiovascular disorder risk;Chemicals;Chili Pepper;Chronic Disease;Clinical;Compensation;Complement;Consumption;COVID-19;Data;Desire for food;Diet;Diet Habits;dietary;Eating;Excess Dietary Salt;experimental study;Food;food flavor;Food Preferences;Future;Goals;Health;hedonic;High Prevalence;Hour;human old age (65+);Hunger;Hypertension;hyposmia;improved;Individual;Intake;Knowledge;Label;Laboratories;Measurement;Measures;Mediating;Myocardial Infarction;National Institute on Deafness and Other Communication Disorders;nutrition;Nutritional Science;Paired Comparison;Participant;Patient Self-Report;Patients;Perception;Persons;Population;Positioning Attribute;Postdoctoral Fellow;preference;prevent;Procedures;Psychophysics;Quality of life;Recommendation;recruit;Reporting;Research;Risk;Risk Reduction;Role;salt intake;Sampling;Sensory;Smell Perception;Sodium;Sodium Chloride;Stroke;Taste Perception;Taste preferences;Techniques;Testing;Training;Urine;Vegetables

PROJECT_TITLE: Modifying salt taste perception, preference, and intake in individuals with smell loss


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Lung;Pulmonary Fibrosis;Rare Diseases;Sarcoidosis

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative The overall goal of this application is to provide support for the candidate to continue to expand her research and mentoring programs in sarcoidosis patient-oriented research. In addition to providing support for mentoring activities, this proposal will determine the relevant mechanisms by which metformin inhibits pulmonary sarcoidosis progression, with a specific focus on pSTAT3 signaling and immuno-metabolomic alterations of the sarcoidosis Th17 cell. The protected time, as well as the expanded clinical and basic research focus, will lay the foundation for future advanced translational investigations of sarcoidosis pathogenesis, thus providing an effective platform for the career development of the next generation of clinical researchers.

PI_NAMEs: DRAKE, WONDER P. (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;Award;Basic Science;Blinded;career development;CD4 Positive T Lymphocytes;Cells;Clinical;clinical investigation;Clinical Research;Clinical Trials;clinically significant;Coculture Techniques;Collaborations;Collagen;cytokine;Data;Development;Disease;Disparity;effector T cell;experience;experimental study;Fibroblasts;Foundations;Future;Genes;genome wide association study;Goals;Granulomatous;Granulomatous disease;Health;Human;IL17 gene;immunoregulation;improved;In Vitro;in vivo;Inflammation;Interstitial Lung Diseases;Investigation;Lung;Mass Spectrum Analysis;Mentors;Metabolic Pathway;metabolome;metabolomics;Metformin;Microarray Analysis;Midcareer Investigator Award in Patient-Oriented Research;next generation;novel;Nuclear Magnetic Resonance;Oral;Outcome;Pathogenesis;patient oriented research;Patients;Peripheral Blood Mononuclear Cell;Phase;Placebos;Production;programmed cell death protein 1;programs;prospective;Pulmonary Fibrosis;pulmonary function;Pulmonary Sarcoidosis;Randomized;receptor;Receptor Signaling;Reporting;Research;Research Personnel;Role;Sarcoidosis;Serum;Signal Pathway;Signal Transduction;STAT3 gene;Stat3 Signaling Pathway;Susceptibility Gene;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;therapy development;Time;Translating;Translational Research;Vital capacity

PROJECT_TITLE: Mentoring in Translational Research in Interstitial Lung Diseases

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Urologic Diseases

ORG_CITY: STANFORD

ORG_DEPT: UROLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE In this study we will develop and apply an artificial intelligence image processing algorithm based on convolutional neural networks for real time detection of bladder tumors during cystoscopy and transurethral resection. Our long-term objective is to improve bladder cancer detection and resection to improve cancer outcomes.

PI_NAMEs: LIAO, JOSEPH C (contact);XING, LEI

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Affect;Algorithms;annotation  system;Appearance;Artificial Intelligence;Artificial Intelligence enhanced;automated segmentation;Base Sequence;Benign;Bladder;Bladder Neoplasm;Body System;Cancer Detection;cancer diagnosis;Cancer Diagnostics;cancer imaging;Cancer Patient;cancer recurrence;cancer risk;cancer surgery;Cancerous;Cessation of life;Clinic;Clinical;cloud based;Communities;Complex;Computer Vision Systems;convolutional neural network;cost effective;Cystoscopy;Data;Data Set;deep learning algorithm;deep neural network;demographics;design;Detection;Diagnosis;Diagnostic;Diagnostic Sensitivity;Ensure;Environment;Equipment;Excision;experience;Future;Goals;healthcare burden;high risk;Histologic;Hospitals;Human;Image;Image Analysis;image guided;image processing;improved;improved outcome;indexing;Inflammatory;Intervention;Knowledge;Learning;Lesion;Light;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Medical center;Medical Imaging;millisecond;Modeling;Morbidity - disease rate;Morphology;mortality;multidisciplinary;neural;Newly Diagnosed;novel;Operating Rooms;Operative Surgical Procedures;Outcome;Papillary;Pathologic;patient stratification;Patients;Performance;Physician Assistants;Predictive Value;Process;prospective;Protocols documentation;Provider;recruit;Recurrence;recurrent neural network;Research;risk stratification;Role;screening;segmentation algorithm;Site;Specificity;Staging;Standardization;Surgeon;Technology;Testing;The Cancer Imaging Archive;Time;tool;Training;training data;Translating;Transurethral Resection;tumor;tumor progression;United States;Universities;Urologist;Urology;Validation;Washington;Work

PROJECT_TITLE: Intraoperative integration of artificial intelligence during cystoscopic surgery

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE The training of the next generation of patient-oriented researchers (POR) is critical for the advancement of science and medicine in the United States. This K24 award proposal is based on Dr. Palaniappan’s plan to use human induced pluripotent stem cells, metabolomics and exosome profiling to model cardiometabolic disease, and aims to use this platform to offer mentorship, education, training, and advocacy for potential K23 awardees. The research aims in this application expand on the scope of two large randomized clinical trials conducted by Dr. Palaniappan which focus on cardiometabolic disease and will provide a variety of innovative POR training venues for her mentees.

PI_NAMEs: PALANIAPPAN, LATHA P (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Adult;Advocacy;Advocate;Affect;American;antiangiogenesis therapy;Area;Award;biobank;Cardiac;Cardiac Myocytes;Cardiometabolic Disease;cardiometabolism;Cardiovascular system;career;career development;Career Mobility;Clinic;Clinical;Clinical Research;Clinical Trials;Collaborations;Complex;Conduct Clinical Trials;Core Facility;Development Plans;Diabetes Mellitus;diabetic;disorder prevention;Education;Educational process of instructing;Endothelial Cells;Enrollment;Environment;Etiology;exercise intervention;Exhibits;exosome;experience;Faculty;field study;Functional disorder;Funding;Gene Pool;Goals;Health;Health Services;hepatic gluconeogenesis;human induced pluripotent stem cells;Individual;innovation;Institution;interest;Intervention;Knowledge;Lead;Medical;medical specialties;Medicine;Mentors;Mentorship;metabolomics;MicroRNAs;Mid-Career Clinical Scientist Award (K24);Modeling;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Nitric Oxide;Non-Insulin-Dependent Diabetes Mellitus;novel;obese person;Obesity;Output;Overweight;Participant;Pathway interactions;patient oriented;patient oriented research;Patients;Persons;Phase;Physical activity;Population;prevent;Prevention;professor;programs;randomized, clinical trials;Regimen;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Research Training;Sampling;Science;stem cells;strength training;Technology;Time;Training;Translating;translational scientist;United States;United States National Institutes of Health;Universities;Weight;Weight maintenance regimen;Work

PROJECT_TITLE: META - Mentor, Educate, Train, Advocate:  Patient Oriented Researchers in Cardiometabolic Disease


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Nutrition;Obesity

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: SUMMARY  Although adipose inflammation is associated with obesity, the defined pathways and their role in the development  of the metabolic sequelae of obesity including non-alcoholic fatty liver disease (NAFLD) remain unclear. Our  studies will determine the cellular and molecular contributors to a novel LIFR-α/JAK/STAT3-dependent  Cytokine-Adipose-Hepatic Axis that facilitates adipose inflammation resulting in increased lipolysis and altered  expression of other inflammatory/metabolic cyto/adipokines in diet-induced obesity. The activation of this axis  limits adipose expansion, resulting in triacylglyceride mobilization from adipose to the liver and ultimately leading  to NAFLD and steatohepatitis.

PI_NAMEs: INFANTE, RODNEY E (contact);IYENGAR, PUNEETH

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Adenylate Cyclase;Adipocytes;adipokines;Adipose tissue;Affect;Animals;Atlases;Blood Vessels;Cell Line;cell type;Cells;comorbidity;comparison control;Complex;counterregulation;Cyclic AMP;cytokine;Cytokine Signaling;Data;Dependence;Development;Diet;diet-induced obesity;Equilibrium;Family;Fatty acid glycerol esters;Genetic;Genetic Models;Hepatic;High Fat Diet;Immune;Immune signaling;in vitro Assay;Inflammation;Inflammatory;inhibitor;Interleukin-6;Knockout Mice;leukemia inhibitory factor receptor;LIF gene;LIFR gene;Lipid Mobilization;Lipolysis;Liver;Mediating;Mediator;Messenger RNA;Metabolic;Modeling;Molecular;mouse model;Mus;non-alcoholic fatty liver disease;novel;Obesity;obesity development;Pathway interactions;Phenotype;Phosphorylation;programs;receptor;Recombinants;Regulation;Resolution;response;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;STAT3 gene;Steatohepatitis;Techniques;transcriptome;transcriptome sequencing;Triglycerides;Wild Type Mouse

PROJECT_TITLE: LIFR-alpha/JAK/STAT3-dependent Adipose Inflammation Contributes to Obesity-Associated NAFLD - Resubmissi

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE Based on its neuroanatomical connection, the mediodorsal thalamus (MD) could be a key taste-processing brain area; however, we have surprisingly very little knowledge on its role in gustation. Here we use electrophysiological recordings and chemogenetic manipulations in behaving rodents to uncover the contribution of MD neurons in integrating taste-related information, modulating neural activity in gustatory cortex (GC), and shaping gustatory behaviors. By providing a comprehensive system-level investigation on the role of MD in taste, these results will help us better understand how the brain controls feeding behavior as well as the circuits involved in dysfunctional eating.

PI_NAMEs: VINCIS, ROBERTO  (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Affective;Amygdaloid structure;Anatomy;Animals;Area;Association Learning;Attention;Auditory;Behavior;Behavior assessment;Behavioral;Behavioral Paradigm;behavioral response;Biological Models;Brain;brain control;Brain region;Cell Nucleus;Citric Acid;Cognitive;Communication;Complex;Cues;Data;design;Eating;Electrophysiology (science);experience;experimental study;Feeding behaviors;Food;Frequencies;genetic manipulation;Goals;hedonic;high reward;Incentives;Investigation;Knowledge;Learning;Measures;Medial Dorsal Nucleus;Modification;multisensory;Mus;Negative Valence;neural;Neuroanatomy;Neurons;Outcome;Pathway interactions;Positive Valence;Process;Property;Quinine;Reporting;Research;response;Rewards;Rodent;Role;Sampling;Sensory;sensory input;sensory integration;sensory stimulus;Shapes;Signal Transduction;Sodium Chloride;Specificity;Stimulus;Sucrose;System;Taste Perception;taste stimuli;Testing;Thalamic structure;Time;Training;virtual;Water;Work

PROJECT_TITLE: Understanding the contribution of the mediodorsal thalamus in gustatory processing

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The inner membrane complex (IMC) is a unique organelle that plays critical roles in host cell invasion and replication in apicomplexan parasites. We previously identified a large number of IMC proteins and have used functional studies to identify those that are essential for parasite survival. This work will determine precisely how these proteins function and interact with their partners which promises to lead to new therapies for T. gondii and related parasites.

PI_NAMEs: BRADLEY, PETER JOHN (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Ablation;Acylation;Affect;Alveolar;Alveolus;Animals;Apical;Apicomplexa;Architecture;Binding;Biotinylation;C-terminal;Cell membrane;Cells;Cellular biology;Coccidiosis;Coiled-Coil Domain;Collaborations;Complement;Complex;Cone;crosslink;Cryo-electron tomography;Cytoskeletal Filaments;Cytoskeletal Modeling;Cytoskeleton;Daughter;daughter cell;design;Disease;Eimeria tenella;Elements;Funding;Grant;Human;human pathogen;in vivo;Invaded;knock-down;knockout gene;Life Style;Malaria;Mediating;Medical;member;Membrane;Microtubules;Molecular;Motility;Motor;Names;Neospora caninum;new therapeutic target;novel;novel therapeutics;obligate intracellular parasite;Organelles;Parasites;pathogen;Pattern;Peripheral;Plasmodium falciparum;Play;Process;protein complex;protein function;Proteins;Proteome;Reporting;Role;scaffold;segregation;Series;Shapes;Structure;Surgical sutures;System;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;unnatural amino acids;Vesicle;Work

PROJECT_TITLE: Functional Analysis of Novel Components of the Toxoplasma Inner Membrane Complex

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: Coronavirus-19 disease (COVID-19) is a global pandemic, and Veterans are at risk of infection and poor outcomes from COVID-19. However, long-term outcomes of COVID-19 have not been characterized or quantified. We will determine outcomes of patients after COVID-19, including their trajectory of health recovery and rehabilitation needs. We will evaluate risk factors for worse long-term outcomes from COVID-19 such as chronic lung disease and other chronic conditions in order to identify individuals at greatest risk of doing poorly and in need of rehabilitation services. We will assess the feasibility and acceptability of a virtually-delivered, home-based personalized telerehabilitation program for survivors of COVID-19. Our pilot study will inform future larger trials of this novel program to determine if it can improve function and well-being of individuals after COVID-19.

PI_NAMEs: CROTHERS, KRISTINA ANNE (contact);TURNER, AARON P.

PROJECT_TERMS: acceptability and feasibility;Acute;Admission activity;Anxiety;Cardiac;Cardiovascular system;Caregivers;Caring;Cessation of life;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Classification;Clinical;Clinical Trials;Cognition;Cognitive;community acquired pneumonia;comorbidity;Complementary Health;Coronavirus;COVID-19;COVID-19 complications;COVID-19 impact;COVID-19 patient;COVID-19 risk;COVID-19 sequelae;COVID-19 severity;COVID-19 survivors;COVID-19 treatment;Critical Care;Critical Illness;Data;design;Dialysis procedure;disability;Discipline of Nursing;Dyspnea;Dyspnea Management;efficacy testing;Electronic Health Record;Environment;Event;Exercise;feasibility testing;follow-up;frailty;functional improvement;functional outcomes;Future;Health;health administration;health related quality of life;Healthcare Systems;Home;Hospital complications;hospital readmission;Hospitalization;illness length;Impairment;improved;Individual;individual patient;Infection;infection risk;Influenza;Inpatients;Integrative Medicine;Intensive Care Units;International;Intervention;Interview;Location;long term consequences of COVID-19;Lung;Mental Depression;Mental Health;Methods;Modeling;mortality;multidisciplinary;Needs Assessment;novel;Nurses;Observational Study;Outcome;Outpatients;Oxygen;Pain;pandemic disease;Patient Recruitments;Patient risk;Patient Self-Report;Patient-Focused Outcomes;Patients;Personal Satisfaction;Physical Function;Physical Medicine;Pilot Projects;pilot test;Pneumonia;Predisposition;programs;prospective;Prospective Studies;Psychology;Quality of life;Recovery;rehabilitation paradigm;rehabilitation service;Rehabilitation therapy;Reporting;Risk;Risk Factors;SARS-CoV-2 infection;satisfaction;Services;Severities;Social Distance;social health determinants;Stroke;Surveys;Survivors;Symptoms;Syndrome;telerehabilitation;Time;uptake;Veterans;Veterans Health Administration;virtual delivery

PROJECT_TITLE: Chronic Lung Disease and COVID-19: Understanding Severity, Recovery and Rehabilitation Needs (LAUREL Study)

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: NARRATIVE Hearing deficits are pervasive in military veterans owing to noise exposures, head trauma, and aging among other factors. To restore hearing completely in the severely damaged cochlea, a biological solution such as stem cell therapy is required to replace the sensory epithelia. Here, we propose a series of experiments deriving inner ear-like donor cells from pluripotent stem cells and implanting these into the deafened auditory epithelium.

PI_NAMEs: DUNCAN, ROBERT KEITH (contact)

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Aging;Animals;Area;Auditory;Auditory Brainstem Responses;Auditory Perception;Auditory Threshold;Biological;Biological Response Modifier Therapy;Cavia;Cell Differentiation process;Cell Maturation;Cell Survival;cell type;Cells;Chronic;Cochlea;Cochlear duct;Cochlear Implants;comparative efficacy;Complex;conditioning;Contralateral;cost;Craniocerebral Trauma;Cuboidal Epithelium;Data;deaf;deafening;Development;Devices;differentiation in vitro;Ear;embryonic stem cell;Engraftment;Environment;Epithelial Cells;Epithelium;Evaluation;Experimental Implants;experimental study;Extracellular Matrix;Generations;genetic approach;Government;Hair Cells;Harvest;hearing impairment;hearing restoration;Histologic;Human;Implant;implantation;improved;in vivo;injured;Injury;Labyrinth;Liquid substance;Longitudinal Studies;Maintenance;Mammals;matrigel;Measurement;method development;Methods;military veteran;mosaic;Mouse Embryonic Stem Cells;Natural regeneration;noise exposure;normal hearing;older patient;Organ of Corti;Organoids;Otic Vesicle;Performance;Pluripotent Stem Cells;Preparation;progenitor;Protocols documentation;psychologic;Recording of previous events;Refractory;Rehabilitation therapy;Replacement Therapy;Reporting;Research;restoration;Role;Sensorineural Hearing Loss;Sensory;Sensory Hair;Series;Severities;social;Specific qualifier value;stem cell biology;stem cell differentiation;stem cell survival;stem cell therapy;stem cells;Stromal Cells;Supporting Cell;Suspensions;Technology;Temporal bone structure;Testing;three dimensional cell culture;Tight Junctions;Tissues;transdifferentiation;treatment choice;Vesicle;Veterans

PROJECT_TITLE: Replacement of the cochlear sensory epithelium using stem cell-derived inner ear organoids

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

ORG_CITY: TBILISI

ORG_COUNTRY: GEORGIA

ORG_FIPS: GG

ORG_NAME: PARTNERSHIP FOR RESEARCH/ACTION/HEALTH

PHR: HIV care continuum gap remains a major problem in the country of Georgia. To help improving national efforts for successful implementation of “End AIDS” strategy in the country this proposal to build capacity in conducting implementation science research that will address gaps in HIV care in the country. This addresses a high priority topic from the NIH strategy on reducing the incidence of HIV/AIDS by implementing strategies to improve HIV testing and entry into prevention services.

PI_NAMEs: DEHOVITZ, JACK A;DJIBUTI, MAMUKA  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Active Learning;Address;AIDS prevention;Caring;Collaborations;Country;Diagnosis;Epidemic;evidence base;Funding;Goals;Grant;Health;Health Sciences;Hepatitis C;HIV;HIV/AIDS;Human immunodeficiency virus test;implementation research;implementation science;improved;Incidence;Institution;institutional capacity;International;Intervention;Investments;Medical center;Needs Assessment;New York;Nongovernmental Organizations;Policy Maker;Population;prevention service;Productivity;programs;Public Health;Public Health Schools;Recommendation;Research;response;Science;Structure;Teacher Professional Development;Training;Training Programs;United States National Institutes of Health;Universities;USSR;Western Asia Georgia

PROJECT_TITLE: Strategic Training Partnership to End AIDS in Georgia


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Despite the importance of extrahypothalamic corticotropin releasing factor (CRF) and its type 1 receptor (CRF1) in the development of ethanol dependence, the role of this system in amygdala-cortical circuits has not yet been delineated. The present application will provide new molecular and circuit information on CRF function and neuroadaptation that may drive ethanol dependence and withdrawal. The results could be invaluable in the development of new pharmacotherapeutics for the treatment of alcoholism.

PI_NAMEs: ROBERTO, MARISA  (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Acute;addiction;Affect;alcohol abstinence;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol response;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholism;alcoholism therapy;Alcohols;Amygdaloid structure;Anxiety;anxiety-like behavior;anxiety-related behavior;Area;Behavior;Behavioral;Cell Nucleus;cell type;Cells;Characteristics;Chronic;Corticotropin-Releasing Hormone;CRF receptor type 1;Data;Dendritic Spines;Development;drinking;drinking behavior;Electrophysiology (science);Emotional;Ethanol;Ethanol dependence;executive function;Female;Fluorescence-Activated Cell Sorting;Genes;Genetic;genetic approach;Glutamates;Grant;Green Fluorescent Proteins;hippocampal pyramidal neuron;Hypothalamic structure;Impairment;In Situ Hybridization;innovation;insight;interdisciplinary approach;Knowledge;male;Medial;Molecular;Molecular Profiling;morphological criteria;Morphology;mouse model;Mouse Protein;Mus;neuroadaptation;neurochemistry;neuronal excitability;Neuronal Plasticity;Neurons;Neuropeptides;patch clamp;Phenotype;Physiological;Play;Population;Prefrontal Cortex;promoter;Property;Public Health;receptor;recruit;Regulation;Relapse;response;Role;sex;Signal Transduction;Stress;Synapses;System;Systems Biology;Testing;tool;transcriptome;transcriptomics;Transgenic Mice;treatment strategy;Viral;Viral Vector

PROJECT_TITLE: Neuroplasticity of the Extended Amygdala CRF circuitry in alcohol dependence

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Precision Medicine;Prescription Drug Misuse;Prevention;Substance Misuse

ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE According to 2018 data collected by the CDC, 128 people die per day from opioid overdose (CDC/NCHS). This number represents the culmination of a 40% increase in deaths attributed to opioid overdose since 2015, despite aggressive public messaging campaigns, policies to curb availability of non-prescription opioids, and wide-spread awareness of the dangers associated with opioid misuse. This proposal aims to understand how individual variability for non-drug rewards relates to escalation of fentanyl-seeking and define the neurocircuitry and genomic contributors to these relationships.

PI_NAMEs: BARDO, MICHAEL T;ORTINSKI, PAVEL IVANOVICH;TURNER, JILL R. (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Acceleration;Animal Behavior;Animal Model;Animals;antagonist;Astrocytes;Awareness;Behavior;Behavior Therapy;Behavioral;Behavioral Model;behavioral pharmacology;behavioral phenotyping;big-data science;Biology;Biometry;Brain;Calcium;Calcium Signaling;cancer therapy;cell type;Cells;Cessation of life;Chronic;Clinical;Clinical Research;Consumption;Coupled;Data;Databases;Dependence;Development;Diagnosis;drug abstinence;Drug Targeting;Drug usage;Economic Burden;Electrophysiology (science);Evaluation;Family;Fentanyl;fentanyl abuse;fentanyl seeking;fentanyl self-administration;fentanyl use;gene product;Genetic Databases;Genetic Markers;genomic biomarker;genomic profiles;genomic signature;Genomics;Goals;Heroin;Human;imaging approach;Individual;Individual Differences;individual variation;Intake;interdisciplinary approach;Joints;Laboratory Animals;Life;Link;Literature;Maintenance;medication-assisted treatment;Microglia;Modeling;Modernization;Molecular;Molecular Profiling;Monitor;Morphine;Motivation;neural circuit;Neurobiology;Neurons;non-drug;novel;novel therapeutics;Nucleus Accumbens;Opiate Addiction;Opioid;opioid misuse;opioid mortality;opioid overdose;Opioid Receptor;opioid use;opioid use disorder;opioid user;Outcome;Output;Patch-Clamp Techniques;Pathway interactions;Pattern;Permeability;personalized approach;personalized cancer therapy;Persons;Pharmaceutical Preparations;Pharmacogenomics;pharmacologic;Phenotype;Play;Policies;Population;Potassium;Potassium Channel;pre-clinical;Prefrontal Cortex;Prevention;Probability;Protein Family;Publishing;Rattus;Regulation;reinforcer;Relapse;Rewards;Role;Sampling;Self Administration;Shapes;Source;Statistical Models;Structure;Substance Use Disorder;success;Sucrose;synthetic opioid;System;targeted treatment;Testing;Therapeutic;Training;transcriptome sequencing;transcriptomics;United States National Center for Health Statistics;Vulnerable Populations;whole genome

PROJECT_TITLE: Functional and Genomic Signatures of Escalated Fentanyl Use

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Despite advances in HIV prevention, the HIV incidence among young men who have sex with men (YMSM) is increasing, threatening to derail achievement of the United States End the HIV Epidemic goals. Although, pre- exposure prophylaxis (PrEP) is a highly effective HIV prevention method, adherence was sufficiently low to comprise efficacy among a high proportion of YMSM in multiple clinical trials and demonstration projects. In this study, we will leverage a novel urine point-of-care drug-level test for PrEP adherence, to both enhance and target adherence counseling among YMSM, with the goal of preventing HIV infections among this critically at- risk group.

PI_NAMEs: SPINELLI, MATTHEW A. (contact)

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: acceptability and feasibility;Achievement;Address;Adherence;Age;AIDS prevention;Anti-Retroviral Agents;Behavior Therapy;Behavioral;Behavioral trial;Biological Assay;brief intervention;care outcomes;career;career development;Cities;Client;Clinic;Clinical;Clinical Investigator;Clinical Trials;cohort;contextual factors;cost;Counseling;critical period;Data;Dedications;design;Development Plans;Diagnostic;Diphosphates;Drug Monitoring;Electronics;Epidemic;Equipment;Evaluation;Feedback;Funding;Future;Goals;Hair;Health system;HIV;HIV anti-retroviral;HIV Infections;HIV risk;HIV Seropositivity;Immunoassay;improved;Incidence;Individual;interest;Intervention;Interview;Knowledge;Maps;Measurement;Measures;Mediator;Medical;medication compliance;men who have sex with men;Mentors;Methods;Modeling;Monitor;Motivation;motivational enhancement therapy;Municipalities;novel;Outcome;Participant;Patient Self-Report;Patients;Pharmaceutical Preparations;pill;point of care;point of care testing;Population;Populations at Risk;pre-exposure prophylaxis;prevent;Preventive;primary care provider;Productivity;programs;Provider;psychosocial stressors;Public Health;Qualitative Research;Randomized;Randomized, Controlled Trials;recruit;reduced substance use;Reporting;Research;Research Design;Research Personnel;Risk;Risk Behaviors;Role;Sampling;San Francisco;screening, brief intervention, referral, and treatment;Sexually Transmitted Diseases;skills;Spectrometry;substance use prevention;Surveys;Tenofovir;Testing;theories;Therapeutic;Therapeutic Uses;therapy adherence;therapy design;therapy development;Time;time use;tool;Training;trial design;United States;United States National Institutes of Health;uptake;Urine;Visit;Work;young men who have sex with men

PROJECT_TITLE: PrEP Point-of-Care Brief-Intervention for Adherence among Young Men Who Have Sex with Men (PrEP2-BAY Study)

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Clinical Research;Nutrition

ORG_CITY: MADISON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The goal of the proposed research is to improve understanding of vocal fold hyperkeratosis, an epithelial disorder for which current treatments carry a risk of voice impairment. Improved understanding of the biology of this disease will lead to new treatment options and improved voice preservation.

PI_NAMEs: TANUMIHARDJO, SHERRY A;WELHAM, NATHAN  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Ablation;Adjuvant Therapy;All-Trans-Retinol;American;analog;Area;Biological Assay;Biological Markers;Biology;Biopsy;Cadaver;candidate marker;candidate validation;Cells;Cellular biology;Chemicals;Chylomicrons;Clinical;clinical application;Clinical Trials;Consensus;Data;dietary;Dietary intake;Dilution Techniques;Disease;disorder control;Dose;Dysphonia;Epithelial Cells;Epithelium;Excision;experimental study;Extrahepatic;Family;Fibrosis;Frequencies;Functional disorder;Goals;Health;Health Care Costs;Histopathology;Human;Hyperkeratosis;iatrogenic injury;Impairment;improved;Intervention;Isotopes;Keratin;Kinetics;Larynx;Lasers;Lesion;Leukoplakia;Literature;Liver;Measures;Mediating;Medical;Metabolism;Modeling;molecular marker;Morbidity - disease rate;mucosal uptake;Mucous Membrane;Nature;novel marker;novel strategies;Nutrient;Occupational;Operative Surgical Procedures;Patients;Performance;Practice Guidelines;pre-clinical;preservation;Quality of life;Rattus;Recurrence;regional difference;Research;Retinoids;Retinol Binding Proteins;Risk;Site;Societies;stellate cell;Supplementation;Surface;Techniques;Testing;Time;Tissues;trafficking;Translational Research;United States;United States Food and Drug Administration;uptake;Vitamin A;vitamin A analog;Vitamin A Deficiency;vocal cord;Voice

PROJECT_TITLE: Pathophysiological profiling of vocal fold hyperkeratosis

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Proposal Narrative Lack of effective imaging methods for detecting residual breast cancer and predicting treatment outcomes remain a major barrier to effective therapy. The proposed research will develop new strategies to enhance imaging signals and map the tumor-stroma ratio noninvasively using optical imaging methods. This work will enable improved detection of small lesions that may harbor recurrent tumor cells and investigate how the relationship between cancer cells and stroma relates to disease outcome.

PI_NAMEs: MICHIE, MEGAN SUZANNE (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Adverse event;Affect;Affinity;Aftercare;Annexins;Antibodies;Atlas of Cancer Mortality in the United States;Binding;Bispecific Antibodies;Breast Cancer Cell;Breast Cancer Detection;Breast Cancer gene;Breast Cancer Patient;Breast Cancer therapy;Breast Cancer Treatment;Cancer Biology;cancer biomarkers;cancer cell;Cancer Detection;Cancer Etiology;cancer imaging;cancer therapy;Cancerous;Cause of Death;cell type;Cells;chemotherapy;Circulation;Clinical;design;Detection;detection method;detection sensitivity;Diagnosis;Disease;Disease Outcome;Drug Kinetics;Dyes;effective therapy;Equilibrium;ERBB2 gene;Exhibits;fibroblast-activating factor;Fibroblasts;Fluorescence;fluorescence lifetime imaging;fluorophore;Foundations;Goals;Histologic;Image;Image Enhancement;imaging agent;imaging modality;imaging platform;imaging probe;Immune;Immunotherapeutic agent;improved;in vivo;in vivo fluorescence;Intervention;Lesion;Ligands;Localized Disease;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Measures;Metastatic breast cancer;Methods;Microscopic;microscopic imaging;Molecular;molecular imaging;Molecular Probes;Molecular Target;Monitor;mortality;mouse model;Mus;Near-infrared optical imaging;Neoplasm Metastasis;neoplastic cell;novel;optical imaging;Optics;optimal treatments;Outcome;overtreatment;Patient-Focused Outcomes;Patients;Penetration;Peptides;personalized medicine;Pharmaceutical Preparations;Phosphorylation;Population;pre-clinical;Prediction of Response to Therapy;Process;Prognosis;prognostic;prognostic indicator;Property;Quality of life;Recurrence;Recurrent disease;Recurrent tumor;Regional Disease;Reporting;Research;Residual Neoplasm;Residual state;side effect;Signal Transduction;small molecule;Specificity;standard of care;Stromal Cells;Survival Rate;targeted agent;targeted biomarker;targeted imaging;targeted treatment;Testing;Therapeutic;Time;Tissues;trait;Transgenic Organisms;Treatment outcome;treatment planning;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Biology;tumor growth;tumor microenvironment;Tumor Tissue;Tumor Volume;Women's mortality;Work

PROJECT_TITLE: Simultaneous Imaging of Tumor and Host Cells in the Microenvironment


NIH_SPENDING_CATS: Autism;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_DEPT: BIOCHEMISTRY

PHR: NARRATIVE Our goal is to define the mechanisms that stabilize neural function throughout life. We have pioneered a sub- field of neuroscience, defining molecular mechanism that homeostatically control neurotransmission and neuronal firing properties. Our work is opening new avenues to treat aging and diseases of the brain.

PI_NAMEs: DAVIS, GRAEME W (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Aging;Animals;autism spectrum disorder;Biological Models;Brain;Brain Diseases;Calcium;Central Nervous System;Data;Disease;Endoplasmic Reticulum;Epilepsy;experimental study;Foundations;Genetic;Goals;Health;Immune signaling;Impairment;insight;interest;Learning;Life;Link;member;Memory;Modeling;Molecular;Nerve Degeneration;Nervous System;Nervous System Disorder;neural;Neurological Models;Neurons;Neurophysiology - biologic function;neuroregulation;Neurosciences;neurotransmission;neurotransmitter release;next generation;novel;Peripheral Nervous System;Phosphotransferases;presynaptic;Property;Reproducibility;Role;sensor;Signal Pathway;Signal Transduction;Synapses;System;Theoretical model;theories;Work

PROJECT_TITLE: Homeostatic Stabilization of Neural Function in Health and Disease


ORG_CITY: Harare

ORG_COUNTRY: ZIMBABWE

ORG_FIPS: ZI

ORG_NAME: BIOMEDICAL RESEARCH & TRAINING INSTITUTE

PHR: This application from the BRTI responsive to Fogarty HIV Research Training Program for Low-and  Middle-Income Country Institutions will build capacity at academic institutions in Zimbabwe for  laboratory, data science and genomics for excellence in HIV research. The program combines  individual level and institutional level capacity building by training young researchers from a  variety of disciplines in the skills required to formulate, conduct and report on research  related  to HIV drug resistance, prevention, pathogenesis and transmission. Effective training of PhDs and  postdoctoral fellows to become research leaders, mentors and supervisors will mitigate brain drain  and develop academic and scientific leadership to guide public health policy and practice at  national level.

PI_NAMEs: MUNYATI, SHUNGU  (contact)

PROJECT_TERMS: Achievement;Address;adolescent woman;African;Articulation;Bioinformatics;Biological;career;Caring;Child;Communities;community based research;community setting;Compensation;Data;Data Analyses;Data Science;design;Development;Discipline;doctoral student;Drug resistance;Ensure;Environment;Epidemic;Epidemiology;Ethics;Evaluation;Fees;Genomics;Goals;Grant;Health;HIV;improved;innovation;Institution;International;Leadership;Medical;Mentors;Methods;Modeling;Molecular;Molecular Epidemiology;Outcome;Outcome Assessment;Output;Pathogenesis;payment;peer;Phylogenetic Analysis;Policies;Population;Positioning Attribute;Postdoctoral Fellow;Prevention;public health priorities;Publications;Research;Research Methodology;Research Project Grants;Resources;Sampling;skills;Social Sciences;student training;Students;Supervision;Training;transmission process;United States National Institutes of Health;Universities;virus genetics;Writing;young woman;Zimbabwe

PROJECT_TITLE: Advanced Training in Community Based Research; training in Bio-informatics, Drug Resistance and Pathogenesis


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Opioids;Pain Research;Patient Safety

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it evaluates a novel therapeutic option—rapid-onset opioids—for exertional dyspnea, one of the most common and distressing symptoms in cancer patients. Rapid- onset opioids are not currently routinely used to treat dyspnea, despite strong theoretical and empirical support, and available treatments for dyspnea are lacking. This project is relevant to the mission of the National Institutes of Health because effective management of dyspnea may ultimately help improve function and quality of life in cancer patients suffering from this devastating symptom; a better understanding of how opioids affect dyspnea will help us to devise new, more effective treatments for this highly debilitating condition.

PI_NAMEs: HUI, DAVID  (contact)

PROGRAM_OFFICER_NAME: PERLOFF, MARJORIE

PROJECT_TERMS: Adverse effects;Affect;Anatomy;arm;associated symptom;Bathing;Breakthrough Pain;cancer pain;Cancer Patient;Clinical Trials;Common Terminology Criteria for Adverse Events;comparative efficacy;confirmatory trial;cost;daily functioning;Data;Data Set;Dimensions;Distress;Dose;Dyspnea;Dyspnea Management;effective therapy;efficacy evaluation;Emergency department visit;EuroQOL;evidence base;Exertion;experience;Fentanyl;Formulation;functional improvement;Goals;Home;Home environment;Hospitalization;improved;Informed Consent;innovation;insight;instrument;Intervention;Malignant Neoplasms;Meta-Analysis;Mission;Morphine Sulfate;Neurocognitive;novel;novel therapeutics;opiate tolerance;Opioid;opioid epidemic;opioid use;Outcome;Outcome Measure;Oxygen;Pain;Patient Care;Patient Monitoring;Patient Outcomes Assessments;patient population;patient tolerability;Patients;Pattern;Pharmaceutical Preparations;Physiological;Placebo Effect;Placebos;prevent;primary endpoint;prophylactic;Prophylactic treatment;Public Health;Quality of life;Questionnaires;Randomized;randomized, clinical trials;Research;Research Design;response;Safety;Series;Symptom Burden;Symptoms;System;Testing;Titrations;United States Food and Drug Administration;United States National Institutes of Health;Walking;Writing

PROJECT_TITLE: Efficacy and Safety of Rapid-Onset Opioids for Exertional Dyspnea in Cancer Patients

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases

ORG_CITY: LIMA

ORG_COUNTRY: PERU

ORG_FIPS: PE

ORG_NAME: UNIVERSIDAD PERUANA CAYETANO HEREDIA

PHR: Our Program for Advanced ReseArch Capacities for AIDS in Peru (PARACAS) plans to expand its current focus of providing long term, sustainable care to people living with HIV/AIDS and actively contribute to eliminating pediatric HIV in Peru. PARACAS will reinforce the doctoral-level Implementation Science mentored-research training for outstanding young and mid-career health researchers; this will allow them to design and test effective interventions tailored to the health context. Our PARACAS renewal should consolidate the proficient and passionate HIV scientific workforce in Peru that is needed to reach an AIDS free generation.

PI_NAMEs: GOTUZZO, EDUARDO  (contact);ZUNT, JOSEPH RAYMOND

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Alabama;Award;career;career development;Caring;Collaborations;Doctor's Degree;Faculty;flexibility;Generations;global health;Goals;Government;Grant;Health;HIV;HIV/TB;implementation science;improved;Individual;Institution;Knowledge;Leadership;Learning;Medical;Mentors;Mentorship;novel;pediatric human immunodeficiency virus;Performance;Peru;Peruvian;Policies;Postdoctoral Fellow;Process;Production;programs;recruit;Research;Research Personnel;Research Priority;Research Training;Scholarship;Science;Talents;Time;Training;Training Programs;transmission process;undergraduate student;United States National Institutes of Health;Universities;Washington;Woman;Work

PROJECT_TITLE: Program for Advanced ReseArch Capacities for AIDS in Peru (PARACAS): harnessing implementation science to enhance care and reduce transmission of HIV


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Data Science;Machine Learning and Artificial Intelligence;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Project Narrative:  Dysregulation in cell metabolism leads to many prevalent human diseases. Yet, tools that are able to map the metabolic activity inside single living cells are lacking. This proposal aims to develop platforms enabling high- speed, high-content, and high-sensitivity mapping of cell metabolism, with a focused application to metabolic reprograming in drug-resistant cancer cells.

PI_NAMEs: CHENG, JI-XIN  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Amino Acids;Amplifiers;anti-cancer research;Bypass;cancer cell;Carboplatin;Cell Physiology;Cell Separation;Cells;Cellular Metabolic Process;Chemicals;Cholesterol;Cisplatin;Collaborations;Computers and Advanced Instrumentation;Data Science;denoising;Development;Drug resistance;Fatty Acids;Fiber;Fingerprint;Glucose;Homeostasis;human disease;Image;imaging platform;improved;Individual;instrumentation;invention;Knowledge;Lasers;Learning;Legal patent;Lipids;Machine Learning;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;Measurement;Measures;Metabolic;metabolic imaging;Metabolism;Microscope;Microscopy;millisecond;Molecular Profiling;multidisciplinary;Noise;novel;Organism;Physiologic pulse;Price;refractory cancer;Research;Resistance;Resolution;Sampling;Scanning;Side;Signal Transduction;spectroscopic imaging;Speed;Stress;submicron;Thinking;Time;Tissues;tool;tumor metabolism;vibration

PROJECT_TITLE: High-content High-speed Chemical Imaging of Metabolic Reprogramming by Integration of Advanced Instrumentation and Data Science

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

PHR: The proposed project focuses on characterizing the genes, regulatory elements and pathways associated with frugivory (fruit based diet). Utilizing primates and bats, both of which have species that have a high fruit diet, we will use a combination of comparative genomics, functional genomics and mouse engineering to detect the genes, regulatory elements and pathways involved in this phenotype. This research will improve genotypephenotype predictions with regards to diet and environment and genetic factors elucidated here have the potential to assist therapeutic developments for people with metabolic diseases like diabetes.

PI_NAMEs: AHITUV, NADAV  (contact)

PROGRAM_OFFICER_NAME: WETTERSTRAND, KRIS A

PROJECT_TERMS: Acceleration;Alleles;Area;ATAC-seq;Bioinformatics;Biological Assay;Candidate Disease Gene;career;Cell Line;cell type;Cells;ChIP-seq;Chiroptera;Collaborations;Comparative Biology;Comparative Genomic Analysis;comparative genomics;Complex;cost;design;Diabetes Mellitus;diabetes risk;Diet;dietary;Discipline;Disease;Eating;Ecology;Educational process of instructing;Endocrine;Engineering;Environment;epigenomics;Ethnic Population;Evolution;Fasting;Festival;Fruit;functional genomics;functional outcomes;Funding;Gene Expression;Genes;Genetic;Genetic Determinism;Genetic Engineering;Genome;genome analysis;Genomics;Genotype;Health education;High School Student;Human;human disease;improved;In Vitro;Insecta;interest;Internships;Kidney;kidney medulla;Laboratories;Learning;Learning Module;Liver;Mammals;member;Mentorship;Metabolic;Metabolic Diseases;Modeling;Molecular;Molecular Evolution;Morphology;mouse genetics;Mus;outreach;Pancreas;Persons;Phenotype;Positioning Attribute;Primates;Proteins;Reagent;Regulatory Element;Regulatory Pathway;Reporter;Research;Resources;RNA;San Francisco;Schools;Science;science education;Scientist;single-cell RNA sequencing;Skeletal Muscle;Small Intestines;Students;sugar;Techniques;Technology;Testing;therapeutic development;Thick;Time;Tissues;Training;trait;transcriptome sequencing;transcriptomics;undergraduate student;Universities;Validation;Variant;Work

PROJECT_TITLE: EDGE CMT: Genomic characterization of mammalian adaptation to frugivory


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Rare Diseases;Urologic Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE STATEMENT Excision of introns from pre-mRNA is critical in the pathway of gene expression. This excision occurs within spliceosomes and requires precise recognition – during both spliceosome assembly and splicing catalysis – of three sites (two splice sites and a branch site) to appropriately join exonic coding sequences. Mutations in components of the U2 snRNP are implicated in myelodysplastic syndrome (MDS) and other cancers, and mutations that alter snRNP levels underlie spinal muscular atrophy (SMA). The roles of small molecule IP6 and mutations in U2 snRNA, identified here, have not previously been investigated. Our studies will provide a better understanding of U2 snRNPs, their interactions with the RNA ligands that are substrates for catalysis, and how disease-related mutations alter this process.

PI_NAMEs: QUERY, CHARLES C (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 3' Splice Site;Alleles;ATP phosphohydrolase;Binding;Binding Sites;Biochemistry;Bioinformatics;bioinformatics pipeline;Biological;Biology;Catalysis;Cell Nucleus;Cells;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complex;Cryoelectron Microscopy;Data;Data Set;Defect;Development;Disease;Dysmyelopoietic Syndromes;Enzymes;Event;Excision;Exons;experimental study;Gambling;Gene Expression;Genes;Genetic;Genetic Screening;Genetic Transcription;genetic variant;Genome;genome-wide;Glioblastoma;Goals;Human;Human Cell Line;human disease;improved;in silico;Individual;Inositol;interest;Introns;Investigation;Joining Exons;Kinetics;Ligands;Link;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mammalian Cell;mammalian genome;Mediating;Methods;Modification;Molecular Conformation;mRNA Precursor;mutant;Mutation;Nucleotides;Organoids;Pathway interactions;Phenotype;Phytic Acid;Polyadenylation;Polyphosphates;Process;Property;Protein Isoforms;Proteins;public health relevance;Reaction;Recurrence;Reverse engineering;RNA;RNA Splicing;Role;SAGA;Site;small molecule;Small Nuclear Ribonucleoproteins;Small Nuclear RNA;Spinal Muscular Atrophy;Spliceosome Assembly Pathway;Spliceosomes;stem;Structure;System;Testing;The Cancer Genome Atlas;Transcription Elongation;transcriptome sequencing;Trinucleotide Repeats;U1 small nuclear RNA;U2 Small Nuclear Ribonucleoprotein;U2 small nuclear RNA;U5 small nuclear RNA;Variant;whole genome;yeast genetics;Yeasts

PROJECT_TITLE: Protein RNA Rearrangements in the Spliceosome

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project narrative (relevance): Despite appropriate treatments, chronic blood disorders such as myeloproliferative neoplasms (MPN) and chronic myelogenous leukemia (CML) (called here collectively MPD) can transform respectively into secondary acute myeloid leukemia (sAML) or blast crisis (BC) CML, which are very poorly responsive to currently available treatments. This proposal seeks to understand the mechanisms through which deficit of a molecule called miR- 142 confers to the MPD cells a more aggressive clinical behavior that transforms them into sAML/BC CML cells. To address the unmet need for effective therapies for these conditions, we will also develop a novel drug called CpG-M-miR-142 designed to restore levels of miR-142 and hopefully to lead to a cure in these otherwise poor- risk patients.

PI_NAMEs: MARCUCCI, GUIDO  (contact);ZHANG, BIN

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Allogenic;Animals;arteriole;B-Lymphocytes;Behavior;Blast Phase;Blood Vessels;Bone Marrow;Bone marrow failure;Cell Differentiation process;Cell Respiration;Cell Survival;Cells;Chromosome abnormality;Chronic;Chronic Myeloid Leukemia;chronic myeloid leukemia cell;Chronic Phase;Chronic-Phase Myeloid Leukemia;Clinical;Clinical Trials;Clonal Evolution;Clonal Hematopoietic Stem Cell;Compensation;Data;density;design;Development;Disease;Dose;Down-Regulation;Drug Kinetics;Dysmyelopoietic Syndromes;effective therapy;Endothelial Cells;Ensure;Erythroid;Exclusion;Experimental Designs;fatty acid oxidation;FLT3 gene;gene conservation;Gene Expression;Goals;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic stem cells;Hemorrhagic Thrombocythemia;Homeostasis;Human;Impairment;In Vitro;in vivo;Institution;knock-down;Knock-out;leukemia;leukemic stem cell;leukemic transformation;Lymphoid;Lymphoma;Malignant Neoplasms;manufacture;Megakaryocytes;Messenger RNA;Metabolism;MicroRNAs;Mitochondria;Molecular;Molecular Abnormality;molecular targeted therapies;Mononuclear;mouse model;Mus;Mutate;Mutation;Myelodysplastic/Myeloproliferative Disease;Myelofibrosis;Myelogenous;Myeloproliferative disease;Names;novel;novel therapeutics;Output;Oxidative Phosphorylation;Pathogenesis;Patient-Focused Outcomes;Patients;PECAM1 gene;Peripheral;Pharmaceutical Preparations;Pharmacodynamics;Play;Polycythemia Vera;precursor cell;prevent;progenitor;Prognosis;prognostic;programs;Proteins;Reactive Oxygen Species;Reporting;Risk;risk stratification;Role;Safety;Sampling;Schedule;Secondary acute myeloid leukemia;Secondary to;self-renewal;Splenomegaly;Stem cell transplant;stem cells;stemness;T-Lymphocyte;Testing;Therapeutic;therapeutically effective;Time;Untranslated RNA;Zebrafish

PROJECT_TITLE: The Role of miR-142 in the Transformation of Clonal Hematopoietic Disorders into AML

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Digestive Diseases;Liver Disease

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PUBLIC HEALTH RELEVANCE: This research will develop and explore a new imaging technology (MR Elastography) that provides unique diagnostic information that cannot be obtained using conventional imaging techniques. The research has already shown that MR Elastography has a promising role in the detection of important complications of chronic liver disease, an important health problem in the US and worldwide, as an alternative to invasive biopsy. MR Elastography has many other potential applications, such as cancer detection.

PI_NAMEs: EHMAN, RICHARD L. (contact)

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: 3-Dimensional;Acceleration;Acoustics;Algorithms;Anisotropy;Awareness;Basic Science;Biological Markers;Biopsy;Brain;Brain Diseases;Breast;Cancer Detection;Cell Physiology;Cells;chronic liver disease;Clinical;clinical application;clinical diagnostics;clinical practice;Clinical Research;clinically relevant;Complex;Computer software;Cytoskeleton;Data;Data Set;design;Detection;Development;Devices;Diagnosis;Diagnostic;Disease;elastography;Engineering;Environment;Evaluation;Evolution;Fibrosis;flexibility;Frequencies;Generations;geometric structure;Goals;Grant;Health;Hepatic;Image;image reconstruction;Imaging Techniques;Imaging technology;improved;in vivo;Inflammation;innovation;Lighting;Liver;liver biopsy;Liver Fibrosis;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;mechanical properties;Mechanics;mechanotransduction;Medical;Medicine;Methods;Modality;Modeling;Modulus;Morphologic artifacts;Motion;motion sensitivity;Motivation;Muscle;nanometer;noninvasive diagnosis;novel;Organ;Patient Care;Patients;Performance;Periodicity;Physiologic pulse;Pilot Projects;Population;Prevalence;Process;Property;Protocols documentation;public health relevance;quantitative imaging;Reaction;Reproducibility;Research;Research Personnel;Resolution;response;Rheology;Role;System;Techniques;Technology;technology development;Testing;Time;Tissue Model;Tissues;tool;Translating;Translations;Validation;volunteer;Work

PROJECT_TITLE: Magnetic Resonance Elastography

STUDY_SECTION: MEDI

STUDY_SECTION_NAME: Medical Imaging Study Section[MEDI]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Microbiome;Neurosciences;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: RELEVANCE TO PUBLIC HEALTH This study will provide new information about how social stressors contribute to obesity among Mexican and Filipino American women. Specifically, it tests the hypothesis that stressors lead to eating behaviors and dietary changes and that alter the brain-gut-microbiome axis. A better understanding of the role of how stress “gets under the skin” to contribute to alterations in the brain and gut microbial metabolites in obesity, could lead to novel therapeutic strategies tailored to treat altered ingestive behaviors and obesity.

PI_NAMEs: CHURCH, ARPANA  (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: Accelerometer;Address;advanced analytics;Affect;Affective;Anatomy;Aromatic Amino Acids;Asian;Autonomic nervous system;Bacteroidetes;Behavior;Behavioral;Biology;Blood specimen;blood-brain barrier crossing;Body mass index;Brain;brain magnetic resonance imaging;Brain region;Calories;Cells;Chronic Disease;Clinical;Cognitive;Communication;Communities;Complex;craving;Cues;Data;data integration;Desire for food;Diabetes Mellitus;Diet;Diet Records;dietary;Dietary Practices;Disease;Disinhibition;Dopamine;dysbiosis;Eating;Eating Behavior;Enrollment;Environmental Impact;Environmental Risk Factor;environmental stressor;ethnic difference;ethnic disparity;ethnic minority;Ethnic Origin;Ethnic Population;Exposure to;Feces;Feeding behaviors;Filipino American;Firmicutes;Food;food consumption;Functional disorder;Gene Expression Profile;gut microbes;gut microbiome;gut microbiota;gut-brain axis;Health;health disparity;Heart Diseases;Hour;Hypothalamic structure;Immune;immune activation;Inequality;Intervention;Knowledge;Kynurenine;Latinx;Lead;learning strategy;machine learning method;Magnetic Resonance Imaging;Measures;Mediating;metabolomics;Metagenomics;Mexican;Mexican Americans;microbial;microbiome;microbiome alteration;MRI Scans;multiple data sources;neuroimaging;Neurologic;neurotransmission;novel;novel therapeutic intervention;Obesity;obesity development;obesity risk;obesogenic;Overweight;Participant;Pathway interactions;Pattern;Phenotype;Physical activity;Play;Positioning Attribute;Process;Public Health;Questionnaires;Race;recruit;Research;Research Support;response;Rewards;Risk Factors;Role;Sampling;Serum;sex;Shotguns;Signal Pathway;Signal Transduction;Skin;social culture;Social Discrimination;social influence;Social isolation;social stressor;stool sample;Stress;stressor;Subgroup;supervised learning;Surveys;System;Systems Biology;Techniques;Testing;Tryptophan;unsupervised learning;waist circumference;Woman

PROJECT_TITLE: Social Isolation and Discrimination as Stressors Influencing Brain-Gut Microbiome Alterations among Filipino and Mexican American


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Prevention

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE We propose to advance and test Medication Education, Decision Support, Reminding, and Monitoring System 2.0 (MEDSReM-2), a theory-based, technology-enhanced comprehensive self-management system that supports hypertension medication adherence and blood pressure (BP) management for non-adherent older adults. MEDReM-2 builds on previously NINR-funded efforts (Multifaceted Prospective Memory Intervention R01; MEDSReM R21), as well as advanced technology tools (e.g., optical image capture, reliable BP monitoring transmitted wirelessly) to foster self-management of hypertension, through greater perceived competence and autonomy, and reduced cognitive demand. We will test the efficacy of MEDSReM-2 in a randomized controlled trial of 224 non-adherent older adults with hypertension, randomized to MEDSReM-2 (n=112) versus education control (n=112), in a 6-month study to assess BP medication adherence (primary outcome), and systolic blood pressure, perceived competence and autonomy, and mobile device proficiency (secondary outcome).

PI_NAMEs: LEE, JEANNIE KIM (contact);ROGERS, WENDY A

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Adherence;Adopted;adverse outcome;Age;age related decline;Algorithms;Behavior;Blood Pressure;blood pressure control;blood pressure medication;Blood Pressure Monitors;Brain;cardiovascular risk factor;Cellular Phone;Cognitive;cognitive ability;cognitive change;cognitive function;cognitive process;Competence;Cues;Databases;design;Dimensions;Discipline of Nursing;Dose;Education;Effectiveness;efficacy evaluation;efficacy testing;Electronics;Enhancement Technology;Ensure;evidence base;executive function;experience;Feedback;Fostering;Funding;handheld mobile device;Health Care Costs;health management;Healthcare;Heart;Heart failure;High Prevalence;Home Blood Pressure Monitoring;human old age (65+);Hypertension;hypertension control;improved;Independent Living;Individual;Individual Differences;Instruction;Intervention;Intervention Studies;Kidney;Label;Measures;Mediation;medication compliance;mobile application;Monitor;Motivation;Myocardial Infarction;older adult;Older Population;optical imaging;Optics;Outcome;Participant;Pattern;Personal Autonomy;Persons;Pharmaceutical Preparations;Population;preservation;primary outcome;Process;prospective memory;Protocols documentation;psychologic;Quality of life;Randomized;Randomized, Controlled Trials;Reporting;Resources;Retina;Risk;Schedule;secondary outcome;Self Determination;Self Management;sex;Short-Term Memory;Stroke;Support System;System;Technology;technology development;Testing;theories;Time;tool;Translating;usability;user-friendly;Visualization;wireless transmission

PROJECT_TITLE: Improving Hypertension Medication Adherence for Older Adults

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


PHR: Low back pain (LBP) causes more years lived with disability than any other health condition. This research will develop and validate approaches to predict LBP-related outcomes for Veterans by leveraging information from the electronic health record and Veterans’ genetic risk profiles. The project will analyze data from the Million Veteran Program and other large genomic biobanks. The information gained from this research may be used in the future to tailor treatment approaches to the unique characteristics of individual Veterans with LBP and lumbar spinal disorders.

PI_NAMEs: SURI, PRADEEP  (contact)

PROJECT_TERMS: Area;biobank;Biological;care outcomes;Caring;Characteristics;Chronic;Chronic low back pain;Clinical;Clinical Data;Coronary Arteriosclerosis;Data;Development;Diagnosis;disability;disability payment;Discrimination;electronic health information;Electronic Health Record;Electronic Medical Records and Genomics Network;Failure;Future;genetic predictors;Genetic Risk;genome wide association study;genome-wide;genomic data;Genomics;Health;Healthcare;high risk;improved;Individual;individualized medicine;Link;Low Back Pain;Meta-Analysis;military veteran;model development;Modeling;Neuropathy;Operative Surgical Procedures;Outcome;outcome prediction;Pain management;pain outcome;Participant;patient subsets;Patient-Focused Outcomes;Patients;personalized approach;Pharmacy facility;Phase;Physical therapy;polygenic risk score;predictive modeling;Prognosis;prognostic model;prognostic value;programs;progression risk;rare mendelian disorder;Recurrence;Rehabilitation therapy;Research;Resources;Risk;risk stratification;ROC Curve;Role;Sampling;Signs and Symptoms;Spinal Diseases;Spinal Manipulation;Spinal Stenosis;Subgroup;Surgical Decompression;Syndrome;Treatment outcome;Validation;Variant;Vertebral column;Veterans;Visit;years lived with disability

PROJECT_TITLE: Identifying genetic predictors of outcomes for Veterans with chronic low back pain and lumbosacral spinal disorders

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Pediatric - AIDS;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Substance Misuse;Tuberculosis

ORG_CITY: PORT-AU-PRINCE

ORG_COUNTRY: HAITI

ORG_FIPS: HA

ORG_NAME: GHESKIO CENTER

PHR: The focus of this training program is to improve HIV-related outcomes of adolescents (10 to 19 years) and youth (20 to 24 years) in Haiti by providing research training to extend adolescent HIV service from the clinic to the community. A multidisciplinary group of investigators, including four PhDs, will be trained in four priority adolescent health research areas including HIV prevention, HIV treatment, HIV/TB co-infection, and HIV and non-communicable diseases. The goal is to train the next generation of Haitian leaders at GHESKIO and the Haitian Ministry of Health who will conduct community-based research with the ultimate goal of improving health outcomes among adolescents and youth in Haiti.

PI_NAMEs: PAPE, JEAN WILLIAM (contact)

PROJECT_TERMS: Address;Adolescent;adolescent health;adolescent health outcomes;Adult;aged;AIDS prevention;antiretroviral therapy;Area;Black American;Caring;Clinic;co-infection;cohort;Communities;community based research;Community Health Aides;cost effectiveness;Data;Development;Disease;Doctor of Philosophy;early onset;Educational Status;Epidemic;Female;Foundations;Future;Grooming;Haiti;Haitian;Health;HIV;HIV-infected adolescents;HIV/TB;Hypertension;Improve Access;improved;Incidence;Infection;Medicine;next generation;Outcome;Poverty;programs;Psychologist;Public Health;Public Health Education;Research;Research Support;Research Training;Services;social;Stigmatization;Training;Training Programs;Training Support;Treatment outcome;Tuberculosis;UNICEF;United States National Institutes of Health;Validation;Youth

PROJECT_TITLE: Research Training Program in Adolescent HIV in Haiti


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Rare Diseases

PHR: PROJECT NARRATIVE Telomere maintenance mechanisms (TMMs) are molecular hallmarks of cancer and are linked to significant metabolic reprogramming in brain tumors. Our goal is to leverage this link to identify novel, translational, metabolic imaging biomarkers that can non-invasively inform on TMM status and, thereby, provide a means of distinguishing tumor from normal brain, edema or necrosis, of monitoring tumor recurrence, of tracking response to therapy including novel TMM inhibitors and of monitoring the development of resistance to TMM inhibitors. This research will, therefore, have the potential to significantly enhance quality of life and care for brain tumor patients.

PI_NAMEs: RONEN, SABRINA MIRIAM;VISWANATH, PAVITHRA  (contact)

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Alanine;Animals;Area;Astrocytoma;ATRX gene;beta catenin;Biological;Biological Markers;biomarker identification;Brain;Brain Neoplasms;cancer cell;Caring;Cell division;Cells;Cellular Metabolic Process;chemotherapy;chromatin remodeling;Clinical;cytochrome c oxidase;Data;Dehydroascorbic Acid;Detection;Edema;Enzymes;Genes;Genetic Engineering;Genetic Transcription;Glioblastoma;Glioma;glioma cell line;Glucose;glucose metabolism;GLUT-3 protein;Glutamates;Glutamine;Goals;homologous recombination;Human;Image;imaging biomarker;imaging modality;improved;in vivo;inhibitor;innovation;knock-down;Link;lipid metabolism;longitudinal analysis;Magnetic Resonance Spectroscopy;Maintenance;Malignant Neoplasms;Melanoma;Metabolic;metabolic imaging;Metabolism;Modeling;Molecular;Monitor;Mutation;Nature;Necrosis;non-invasive imaging;non-invasive monitor;novel;Nuclear;oligodendroglioma;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;PDH kinase;personalized care;pharmacologic;Play;Principal Component Analysis;Proliferating;Proteins;Quality of life;Radiation therapy;Recurrent tumor;Reduced Glutathione;Research;Resistance;Resistance development;response;Reverse Transcriptase Inhibitors;RNA-Directed DNA Polymerase;Role;Somatic Cell;Structure;Telomerase;Telomerase inhibition;Telomerase Inhibitor;telomere;Telomere Capping;Telomere Maintenance;Telomere Pathway;Therapeutic;therapeutic target;Tissues;tool;treatment response;tumor;Tumor Burden;Xenograft procedure

PROJECT_TITLE: IMAGING TELOMERE MAINTENANCE MECHANISMS IN GLIOMAS

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Facioscapulohumeral Muscular Dystrophy;Genetics;Muscular Dystrophy;Rare Diseases

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE The proposed research will identify the molecular mechanisms of cellular toxicity and dysregulation induced by DUX4 through modulation of RNAs, double-stranded RNAs, and the innate immune response pathways induced by double-stranded RNAs. The health relevance of this research is that these mechanisms contribute to the pathophysiology of facioscapulohumeral muscular dystrophy and the proposed studies will provide the basis for future therapeutic development.

PI_NAMEs: TAPSCOTT, STEPHEN J (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Cells;Centromere;Code;Complex;D4Z4;DNA;DNA Damage;DNA Double Strand Break;Double-Stranded RNA;Elements;Embryo;Facioscapulohumeral;Facioscapulohumeral Muscular Dystrophy;Functional disorder;Future;Gene Expression;gene induction;Genes;Genetic Transcription;Genome;Genomic Instability;Genomic Segment;Goals;Health;Immune signaling;Innate Immune Response;Interferons;Messenger RNA;Modeling;Molecular;Mus;Muscle Cells;Muscle Fibers;Muscular Dystrophies;Pathology;Pathway interactions;Post-Transcriptional Regulation;protein function;Proteins;Publishing;Research;response;Retrotransposon;Ribonucleoproteins;RNA;RNA Stability;Role;scaffold;Signal Pathway;Signal Transduction;Skeletal Muscle;Testing;therapeutic development;Therapeutic Intervention;Toxic effect;Transcript;transcription factor;Translations;Validation;Work

PROJECT_TITLE: D4Z4 Coding Transcripts and FSHD

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cerebrovascular;Immunotherapy;Neurosciences;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: The proposed research is relevant to public health because the development of imaging tools capable of assessing structural and functional changes in the brain’s microvessels (i.e. vasculome) over the life cycle of a brain tumor model will yield invaluable insight into their role in brain cancer progression, tumor spread, and treatment efficacy. The proposed research is relevant to the NIH’s mission because the assessment of changes in the vasculome of patient-derived brain tumor models over their entire lifetime would help elucidate the role of non-angiogenic brain tumor growth in resistance to antiangiogenic therapies, vascular modulation associated with immunosuppression of the brain tumor microenvironment, and help identify new biomarkers and treatment strategies for patients with brain cancer.

PI_NAMEs: PATHAK, ARVIND P (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: 3D Print;Alzheimer's Disease;Anesthesia procedures;Anesthetics;angiogenesis;Angiogenesis Inhibitors;Animals;anti-cancer research;Arteries;awake;behavioral study;biomarker identification;blood vessel development;Blood Vessels;Brain imaging;Brain Neoplasms;brain tumor imaging;cancer imaging;CD47 gene;Cells;cellular engineering;Central Nervous System;cerebral blood volume;cerebral microvasculature;Cerebrovascular Circulation;Clinical;clinically relevant;Data;design;Development;Devices;Disease;Drug Delivery Systems;Dyes;Electroencephalography;Exhibits;fabrication;Fluorescence;fluorescence imaging;fluorophore;Gene Expression;Glioblastoma;Glioma;Goals;Histologic;Histology;Hour;Image;imaging capabilities;Imaging Device;imaging modality;imaging system;immune cell infiltrate;Immune Evasion;Immune response;Immunocompetent;immunoregulation;Immunosuppression;Immunotherapy;in vivo;in vivo imaging;insight;Knock-out;Lasers;Life Cycle Stages;Lighting;Magnetic Resonance Imaging;Malignant neoplasm of brain;Maps;Measurement;Mediating;meter;Microscope;miniaturize;Mission;Modeling;Morphology;Motivation;Mus;neoplastic cell;neuroimaging;novel therapeutics;operation;Optics;optogenetics;overexpression;Pathway interactions;patient derived xenograft model;Patients;Perfusion;Phenotype;Physiological;Play;pre-clinical;Public Health;Quail;real-time images;recruit;Research;Resistance;Resolution;Role;sensor;Signal Transduction;Stroke;structural imaging;Structure;System;therapy resistant;Time;transmission process;Treatment Efficacy;treatment response;treatment strategy;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumor-immune system interactions;United States National Institutes of Health;Validation;Vascular remodeling;Veins;wireless;wireless fidelity;Wireless Technology;wireless transmission;Xenograft procedure

PROJECT_TITLE: A Wireless Multi-function Microscope for Lifetime Imaging of the Brain Tumor Vasculome


NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Racial and Ethnic Minority Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative We aim to use whole genome sequence and blood omic biomarkers in the NHLBI Trans-Omics for Precision Medicine (TOPMed) study to illuminate the pathobiology of type 2 diabetes (T2D) and its quantitative traits fasting glucose, insulin and hemoglobin A1c. We will integrate TOPMed results with beta cell-, liver-, fat- and muscle-specific omics and epigenomic annotation in the Accelerating Medicine Partnership (AMP) T2D Diabetes epiGenome Atlas and with hundreds of additional genomic trait associations in the AMP T2D Knowledge Portal for ‘in silico variant-to-function’ and phenomic studies aimed to find new approaches to address the global epidemic of T2D.

PI_NAMEs: MANNING, ALISA KNODLE (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Acceleration;Address;Affect;African American;Age;Alleles;aptamer;Asian;ATAC-seq;Atlases;Beta Cell;biobank;Bioinformatics;Biological;Biological Markers;Biology;Blood;cardiometabolism;case control;catalyst;Cells;Cessation of life;ChIP-seq;Clinical Data;Code;cohort;Collaborations;Data;data portal;database of Genotypes and Phenotypes;Development;Diabetes Mellitus;Dimensions;Disease;DNA Methylation;East Asian;Environment;Epidemic;epigenome;epigenomics;Etiology;European;Event;fasting glucose;Fatty acid glycerol esters;follow-up;Future;Gene Frequency;Genes;Genetic;Genetic Risk;genetic variant;Genome;genome wide association study;Genomics;glycemic control;Glycosylated hemoglobin A;Goals;Health;Hemoglobin;Hepatic;Hi-C;high dimensionality;Hispanic;Human;in silico;Individual;insight;Insulin;Insulin Resistance;Intention;islet;Knowledge;Knowledge Portal;Latino;Lead;liquid chromatography mass spectroscopy;Liver;Maps;Measures;Medicine;Mendelian randomization;metabolomics;Methods;methylomics;Minor;Minority Groups;Molecular;multidimensional data;multidisciplinary;Muscle;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;network models;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;obesity genetics;Odds Ratio;Pathway interactions;Peptides;phenomics;Physiological;Physiology;polygenic risk score;Population;Populations at Risk;Positioning Attribute;Proteins;Proteomics;Race;rare variant;Risk;risk variant;Samoan;Sequence Analysis;Series;Single Nucleotide Polymorphism;statistics;System;targeted treatment;Testing;Tissue atlas;Tissues;trait;Trans-Omics for Precision Medicine;Transcript;transcriptome sequencing;transcriptomics;Translations;Untranslated RNA;Variant;Whole Blood;whole genome;working group

PROJECT_TITLE: TOPMed Omics of Type 2 Diabetes and Quantitative Traits

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(02)]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

PHR: Narrative  The recent trend in opioid drug abuse and overdose deaths has reached an epidemic level. Naltrexone has shown great promise in assisting people recovering from opioid dependence, but current treatment induction and regimens remain problematic for many. The goal of this project is to optimize and advance a patient-friendly, 380 mg 2- month naltrexone PLGA formulation from the lab scale to phase I clinical trials.

PI_NAMEs: PARK, KINAM  (contact)

PROGRAM_OFFICER_NAME: SOUSA, JASON CARLOS

PROJECT_TERMS: Acceleration;Accidents;addiction;Adherence;biocompatible polymer;carfentanil;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;combat;Consumption;controlled release;Data;design;Development;Development Plans;Dose;drug addict;Drug Delivery Systems;Drug Kinetics;Epidemic;Evaluation;Excipients;FDA approved;Fentanyl;first responder;Formulation;Friends;Glycolic-Lactic Acid Polyester;Goals;Illicit Drugs;improved;In Vitro;in vivo;Injectable;Injections;innovation;Internet;Kinetics;Laboratories;lead candidate;manufacture;manufacturing scale-up;Marketing;meter;Methods;Molecular;Naltrexone;Needles;non-compliance;novel;Opiate Addiction;Opioid;opioid abuse;Opioid Analgesics;Opioid Antagonist;opioid epidemic;opioid overdose;opioid use disorder;opioid user;Oral;Outcome;Overdose;overdose death;Pain;Paramedical Personnel;particle;Particle Size;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Police officer;pre-Investigational New Drug meeting;prescription drug abuse;prevent;Price;Primates;Process;product development;programs;Property;Rattus;Regimen;Relapse;Research;research and development;small molecule;Societies;sound;Source;Street Drugs;Syringes;System;Technology;Testing;therapeutically effective;Time;tool;trend;Withdrawal Symptom

PROJECT_TITLE: Injectable naltrexone 2-month depot formulations


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE (Public Health Relevance) Significant expense and effort by groups of scientists around the world has led to identification of regions of the human genome that are associated with the genetic risk for various forms of cardiovascular disease, including coronary artery disease. Additional research is required to understand the specific genes involved, and how they work to contribute to the disease process. Such information will allow for better risk assessment and the development of better therapeutics for these diseases.

PI_NAMEs: QUERTERMOUS, THOMAS  (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Affect;Apolipoprotein E;Binding;Binding Sites;Blood Vessels;Cardiovascular Diseases;causal variant;cell dedifferentiation;Cell Lineage;cell type;Cells;Chondrocytes;Chromatin;Chromosome Mapping;Complement;Complex;Coronary Arteriosclerosis;Coronary artery;Coronary heart disease;CRISPR interference;CRISPR/Cas technology;Data;Development;Disease;Disease Pathway;disorder risk;Enhancers;Epigenetic Process;epigenomics;Etiology;experimental study;Exposure to;Fibroblasts;Funding;Gene Expression;Gene Expression Profile;gene network;gene regulatory network;Genes;Genetic Epistasis;Genetic Risk;Genetic Transcription;Genome;genome wide association study;genome-wide;Genomics;Goals;Human;Human Genome;In Vitro;in vivo;Joints;knock-down;Knockout Mice;Lesion;Link;Maps;Medial;Mediating;Methods;migration;Modeling;Molecular;Mus;Osteogenesis;Phenotype;Process;Proliferating;Promoter Regions;public health relevance;Quantitative Trait Loci;Research;response;Risk Assessment;Scientist;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;Smooth Muscle Myocytes;Stress;Subcellular Anatomy;Therapeutic;Tissues;transcription factor;vascular stress;Work

PROJECT_TITLE: Causal variant association mechanisms in TCF21 binding coronary disease loci

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]