ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project narrative GABAergic neurons are diverse and implicated in many diseases such as epilepsy and schizophrenia. The main goal of this application is to generate genetic tools so that it will become possible to investigate the functions of specific subclasses of GABAergic neurons.

PI_NAMEs: ZHUANG, XIAOXI  (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Adult;Affect;Area;Basal Ganglia;brain morphology;Bypass;cell type;cofactor;Communities;Corpus striatum structure;Cre driver;dietary;Disease;Disinhibition;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;dopaminergic neuron;drinking;Drosophila genus;Electrophysiology (science);Elements;Enzymes;Epilepsy;experimental study;feasibility testing;feeding;gamma-Aminobutyric Acid;Gap Junctions;Genetic;Glutamate Decarboxylase;Glutamates;Goals;Health;Human;inhibitory neuron;Injections;Internal Ribosome Entry Site;Interneurons;Knock-out;knockout gene;LoxP-flanked allele;Measures;Mediating;Memory;Modeling;Morphology;Motor;Motor Activity;motor learning;Motor output;mouse model;Mus;Mutation;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;Neonatal;Nervous System;Neurons;Neuropeptides;Neurosciences Research;Neurotransmitters;novel strategies;Parvalbumins;Pathway interactions;Physiological;postsynaptic;presynaptic;Property;Pyridoxal Phosphate;Pyridoxine 5 Phosphate Oxidase;Research;response;Reversal Learning;Schizophrenia;Seizures;Short-Term Memory;Sleep;Synaptic Receptors;Testing;tool;transmission process;Tyrosine 3-Monooxygenase;Vitamin B6

PROJECT_TITLE: Generating mouse models with cell type-specific and reversible GABA deficiency

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Burden of Illness;Cancer;Clinical Research;Health Services;Kidney Disease;Prevention;Rare Diseases;Urologic Diseases

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_FIPS: US

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Chronic kidney disease (CKD) is present in nearly 20% of the mid-life U.S. population, and recent large cohort studies have raised the independent association of CKD with cancers of the urinary system. With elevated rates of cancer-specific mortality and common coexisting risk factors for renal or urothelial cancers (smoking, obesity, and hypertension), mid-life patients with CKD merit evaluation for cancer screening. We will build a simulation model for urinary system cancer screening, accounting for cancer-specific morbidity and mortality as well as competing mortality risks, and include stakeholder input on the acceptability of benefits and harms.

PI_NAMEs: KANG, STELLA  (contact)

PROGRAM_OFFICER_NAME: SHELBURNE, NONNIEKAYE F

PROJECT_TERMS: Accounting;Address;Adherence;Adult;Affect;Aftercare;Age;aged;Anatomy;black men;black women;Bladder;Calibration;Cancer Burden;cancer risk;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Caring;Cause of Death;Cessation of life;Chronic Kidney Failure;Classification;Clinical;clinical practice;Cohort Studies;Colorectal Cancer;comorbidity;Complex;Computer Simulation;cost;cost effective;cost effectiveness;cost estimate;Data Set;Detection;Diagnosis;Epidemiology;Evaluation;Event;experience;Frequencies;General Population;Goals;Guidelines;hazard;Health;Health Status;human old age (65+);Hypertension;improved;Incidence;Internal Medicine;K-Series Research Career Programs;Kidney;Kidney Neoplasms;Life Expectancy;Link;Magnetic Resonance Imaging;Malignant neoplasm of lung;Malignant neoplasm of ureter;Malignant neoplasm of urinary bladder;Malignant Neoplasms;middle age;Modeling;models and simulation;Monitor;Morbidity - disease rate;mortality;mortality risk;Natural History;Nephrology;Obesity;Outcome;Pathway interactions;Patient advocacy;patient subsets;Patients;Perception;Persons;Population;Population Heterogeneity;Practice Guidelines;Prevention strategy;Primary Care;Proteinuria;Public Health;Publishing;Quality of life;Quality-Adjusted Life Years;Radiology Specialty;Recommendation;Recurrence;Renal Carcinoma;Renal Cell Carcinoma;Renal function;Renal Mass;Risk;Risk Factors;Science;screening;Screening for cancer;screening guidelines;Severities;Severity of illness;Smoking;Subgroup;Testing;Translating;ultrasound;urinary;Urinary system;Urinary tract;Urologic Cancer;Urologic Oncology;Urology;Urothelium;Work;young man

PROJECT_TITLE: Tailored Screening for Urinary System Cancers in Patients with Chronic Kidney Disease

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Nashville

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative This research will establish how blood oxygenation level dependent (BOLD) signals in white matter (WM), detected using functional magnetic resonance imaging (fMRI), are related to neural activity in gray matter (GM). The results will demonstrate how WM and GM activities are related, how to integrate them to obtain a more complete model of brain organization, and will lay a firm foundation for exploiting measurements of functional connectivity in white matter across a spectrum of disorders and conditions.

PI_NAMEs: DING, ZHAOHUA  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: 3-Dimensional;Address;Age;Algorithms;Alzheimer's Disease;Atlases;Behavior;behavior measurement;Behavioral;blood oxygen level dependent;Brain;Cognition;Cognitive;cognitive function;Communication;connectome;Data;Data Set;density;Diffusion;Diffusion Magnetic Resonance Imaging;digital;Disease;Exclusion;Fiber;Foundations;Functional Imaging;Functional Magnetic Resonance Imaging;Gender;Goals;gray matter;hemodynamics;Human;Image;imaging study;independent component analysis;innovation;Investigation;Light;Measurement;Measures;Methodology;Methods;Modeling;Multiple Sclerosis;neural;Parkinson Disease;Pathologic;Pathology;Pattern;Reproducibility;Research;Resolution;response;Rest;Schizophrenia;Signal Transduction;Standardization;Stimulus;Stroke;Structure;Surface;Testing;Time;tractography;Variant;white matter;Work

PROJECT_TITLE: Functional Connectome of Brain White Matter

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Pediatric;Prevention

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE PUBLIC HEALTH RELEVANCE: Early-onset atrial fibrillation is a disordered rhythm in the top part of the heart that occurs before 35 years of age and typically requires medical, interventional and/or surgical management. Genetic abnormalities in the atrium may be easier to detect and describe in children, but have implications for a disease that affects millions of adults every year. This prospective, observational study will enroll patients with early onset atrial fibrillation, perform genomic sequencing, and perform clinical follow-up for two years to determine whether genetic substrate is associated with earlier recurrence of atrial fibrillation.

PI_NAMEs: WEBSTER, ROBERT GREGORY (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: Address;Adult;Affect;Age;age group;Age of Onset;Age Years;Apple watch;Arrhythmia;Atrial Fibrillation;Biological;Cardiac;Cardiomyopathies;cascade genetic testing;Child;Clinical;clinical care;Clinical Data;Clinical Markers;clinical practice;clinical predictors;clinically relevant;cohort;comparison control;Data;data analysis pipeline;de novo mutation;design;Disease;disease-causing mutation;early onset;Electrocardiogram;Event;Exclusion;Family;Family history of;follow-up;Frequencies;Future;gene discovery;gene panel;Genes;Genetic;genetic information;Genetic Markers;Genetic Materials;genetic panel test;Genetic Predisposition to Disease;Genetic Risk;Genetic study;genetic testing;genome sequencing;genome wide association study;Genomic approach;Genomics;Genotype;Goals;Heart;Heart Atrium;Heart Diseases;human old age (65+);Incidence;Intervention;Investments;Link;Medical;Molecular Abnormality;Morbidity - disease rate;mortality;Myocardial;Myopathy;National Heart, Lung, and Blood Institute;novel;novel strategies;Observational Study;older adult;Operative Surgical Procedures;Outcome;Parents;participant enrollment;participant interview;Pathogenicity;Pathway interactions;Patient Recruitments;Patients;pediatric cardiologist;Persons;Pharmaceutical Preparations;Phenotype;polygenic risk score;Population Control;Prevalence;prevent;Prevention;proband;progression risk;prospective;Prospective Studies;public health relevance;rare variant;Recommendation;Recording of previous events;Recurrence;Reporting;Risk;Risk Factors;Risk Marker;risk variant;Shock;Surgical Management;Testing;Time;Translating;United States National Institutes of Health;Variant;wearable device;whole genome;Work;young adult

PROJECT_TITLE: Investigating structural and genetic substrates of early-onset atrial fibrillation

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE We will carry out the first unbiased high-throughput exploration of genes governing bacterial DNA supercoiling, an essential property holding great untapped promise for therapeutic manipulation. This exploration will reveal novel factors that dictate the abundance and activity of the two enzymes that control DNA supercoiling: DNA gyrase and topoisomerase I. This project capitalizes on a technological innovation developed in our lab, as well as our track record solving fundamental biological questions using the model pathogen Salmonella enterica serovar Typhimurium, to shift the paradigm of DNA supercoiling control and identify novel antibacterial targets.

PI_NAMEs: GROISMAN, EDUARDO  (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Acceleration;Adenosine Diphosphate;Adenosine Triphosphate;Animal Model;Anti-Bacterial Agents;Anti-Infective Agents;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteria;Bacterial DNA;Bacterial Physiology;bacterial resistance;base;Behavior;Biological;Cells;Chloroquine;Development;DNA;DNA Gyrase;enzyme activity;Enzymes;Evaluation;experience;exposure pathway;Exposure to;Face;Fluorescence;Fluoroquinolones;gene discovery;Genes;Genetic;Growth;high throughput screening;Human;human pathogen;Infection;Infectious Agent;inhibitor;Laboratories;Link;Magnesium;Methods;Modeling;mutant;Mutate;Mutation;Mycobacterium tuberculosis;novel;novel strategies;Osmolar Concentration;Output;pathogen;Pathway interactions;Pharmaceutical Preparations;Phenotype;Physiological;plasmid DNA;Polyamines;Predisposition;Process;programs;Property;Proteins;Putrescine;Relaxation;Reporting;Research;response;RNA;Salmonella typhimurium;Sepharose;Site;Spermidine;Stress;Superhelical DNA;targeted agent;technological innovation;Technology;Temperature;Therapeutic;Time;Toxic effect;Type I DNA Topoisomerases

PROJECT_TITLE: A Novel High-Throughput Exploration of DNA Supercoiling toward the Therapeutic Manipulation of Bacteria

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_NAME: NEW YORK GENOME CENTER

PHR: PROJECT NARRATIVE Genetic studies have and continue to identify a large number of genetic associations with neuropsychiatric disorders, however translating these into causal genes or variants, biological mechanisms, and therapeutic targets remains a major challenge. Here, we develop a suite of computational innovations to 1) determine the shared and distinct genetic components of neuropsychiatric disorders, 2) infer the causal gene networks underlying these components, and 3) model how common and rare genetic variants disrupt these networks. These novel methods will be applied to genotyping and sequencing data from both early onset disorders such as Autism spectrum disorders and developmental delay, and later onset disorders in particular schizophrenia, bipolar disorder and major depressive disorder.

PI_NAMEs: KNOWLES, DAVID ARTHUR (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Algorithms;autism spectrum disorder;Automobile Driving;Biological;Biology;Bipolar Disorder;Brain;cancer genomics;causal variant;Cell model;cell type;Chromatin;CISH gene;Clinical;Code;Collaborations;comorbidity;computational suite;Computer Analysis;Data;Developmental Delay Disorders;developmental disease;Diffusion;Disease;disorder risk;Documentation;driver mutation;early onset disorder;empowerment;Etiology;exome sequencing;expectation;Formulation;Future;Gene Expression Regulation;gene network;gene regulatory network;Genes;Genetic;genetic association;Genetic Processes;Genetic Risk;Genetic study;genetic variant;Genetic Variation;genome sequencing;genome wide association study;Genotype;Graph;Growth;Health;Heterogeneity;Human;improved;innovation;International;Late-Onset Disorder;Licensing;Linkage Disequilibrium;Major Depressive Disorder;Maps;Mental disorders;Methods;Modeling;Molecular Conformation;Nature;Network-based;neuropsychiatric disorder;neuropsychiatry;novel;Pathogenesis;Pathway interactions;Pattern;phenome;Phenotype;Principal Component Analysis;Process;psychiatric genomics;Quantitative Trait Loci;Rare Diseases;rare variant;Regulator Genes;Regulatory Element;Regulatory Pathway;Reproducibility;Role;Sample Size;Sampling;Schizophrenia;single nucleus RNA-sequencing;Source;statistics;Structure;Symptoms;Therapeutic Intervention;therapeutic target;trait;Transgenes;Translating;Untranslated RNA;Variant;Work

PROJECT_TITLE: Delineating the network effects of mental disorder-associated variants using convex optimization methods

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: PROJECT NARRATIVE Genome editing technologies like nucleases, base editors, and prime editors may become safe and effective genomic medicines to treat monogenic human diseases either ex vivo or in vivo. Although fit-for-purpose biochemical methods like CHANGE-seq and gRNA sequencing have advantages as highly-sensitive IND- enabling assays for nucleases and base editors, to our knowledge, fully optimized and qualified protocols for use in regulatory submissions are not generally available. Here we propose to optimize and qualify CHANGE- seq adapted for nucleases and base editors, and associated gRNA sequencing, for use in future therapeutic genome editing INDs.

PI_NAMEs: TSAI, SHENGDAR  (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Acceleration;Affect;base editor;Biochemical;Bioinformatics;Biological Assay;cancer immunotherapy;Cells;Chemistry;Clinic;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Computer software;Data;design;Development;DNA Integration;Ensure;Eye;first-in-human;Frequencies;Future;gene therapy;Gene Transduction Agent;Genetic Diseases;Genome;Genome Components;genome editing;genome editor;genome-wide;Genome-wide Unbiased Identification of DSBs Enabled by sequencing;Genomic DNA;Genomic medicine;Genomics;Goals;Guide RNA;High-Throughput Nucleotide Sequencing;human disease;Human Genome;improved;in vivo;Inherited;Investigational Drugs;leukemia;Liver;manufacture;member;Methods;novel;nuclease;off-target mutation;off-target site;Outcome;Patients;Performance;Pharmaceutical Preparations;prime editor;Proto-Oncogenes;Protocols documentation;Publishing;Qualifying;Reagent;Research Methodology;Retinal Diseases;Risk;Safety;safety assessment;Sickle Cell Anemia;Site;Specificity;Technology;Testing;Therapeutic;therapeutic genome editing;therapeutically effective;Translations;Viral Genes

PROJECT_TITLE: Ultra-sensitive, unbiased, high-throughput, biochemical CHANGE-seq genome-wide activity and gRNA sequencing assays for therapeutic genome editing INDs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-M(70)R]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE The phagocytes of the immune system require a rapid burst of energy to fight infections and to clear cellular debris. Our long-term goal is to understand the intracellular signals and machinery that reallocate the metabolic resources necessary for cellular defense against pathogens. Doing so will reveal novel molecular targets and pathways to modify immunological processes for clinical benefit. Toward that end, this application breaks new ground by defining how phagocytes use mitochondrial Ca2+-signaling to fuel cell-intrinsic defense mechanisms against microbial pathogens. The research has the potential to lead to drugs that can enhance our immunity or modulate it, and thus address critical needs in public health.

PI_NAMEs: DESAI, BIMAL N. (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: 3-Dimensional;Address;antimicrobial;Apoptotic;Architecture;Basic Science;Binding;Biogenesis;Bone Marrow;Calcium Signaling;calcium uniporter;Candida albicans;Cells;Citrates;Citric Acid Cycle;Clinical;Complex;Data;Defense Mechanisms;design;Detection;EF Hand Motifs;electron tomography;Exhibits;fascinate;fighting;Foundations;Gatekeeping;Gene Expression;Goals;Human;Hybrids;Immune response;Immune system;Immunity;Immunologics;immunomodulatory therapies;immunoregulation;in vivo;Infection;Inflammatory;Inner mitochondrial membrane;innovation;interest;Ion Channel;light microscopy;Lipids;Macromolecular Complexes;Macrophage;Mediating;Mediator;Metabolic;Metabolic stress;Metabolism;microbial;Mitochondria;Mitochondrial Matrix;mitochondrial membrane;mitochondrial metabolism;Molecular;Molecular Machines;Molecular Target;Monitor;Movement;Mus;Mutation;Myeloid Cells;NADP;NADPH Oxidase;Neuromuscular Diseases;novel;Organelles;Output;pathogen;Pathogen detection;pathogenic fungus;pathogenic microbe;Pathogenicity;Pathway interactions;Phagocytes;Phagocytosis;Phagosomes;Pharmaceutical Preparations;Phase;Physiology;Play;pre-clinical;Process;Production;programs;Public Health;Publishing;pyruvate dehydrogenase;reconstruction;recruit;Regulation;Reporting;Research;Resources;response;Rest;Role;Sensory Receptors;Sentinel;Signal Transduction;Small Interfering RNA;stoichiometry;synaptic pruning;Testing;tool;transmission process;Ubiquitination;vacuolar H+-ATPase

PROJECT_TITLE: Mitochondrial Calcium Signaling in Cell Intrinsic Immunity

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurosciences

PHR: PROJECT NARRATIVE The Kv3.3 potassium channel regulates the excitability of neurons in the auditory system and cerebellum. Mutations in the gene for Kv3.3 in humans results in disorders of movements and an inability to localize sounds is space. The experiments in this proposal will determine how such mutations alter cellular signaling in auditory neurons and will provide novel therapeutic approaches to counteract the effects of these mutations.

PI_NAMEs: KACZMAREK, LEONARD K (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acoustic Stimulation;Actins;Acute;Affect;Animals;Apoptotic;Auditory;auditory processing;Auditory system;Binding;Biochemical;Brain;Brain Stem;C-terminal;Cell Line;Cell membrane;Cell Nucleus;Cell Survival;Cerebellar degeneration;Cerebellum;Complex;Coupled;Cytoplasm;Cytoplasmic Tail;Cytoskeleton;Degenerative Disorder;Development;Disease;Down-Regulation;Electric Capacitance;Endocytosis;Environment;Enzyme Inhibition;Enzymes;experimental study;Genes;Genetic;genetic approach;genetic manipulation;Human;Image;Impairment;in vivo;insight;Ion Channel;Measurement;Medial;Microfilaments;Motor;Movement Disorders;Mutagenesis;mutant;Mutation;neuronal excitability;Neurons;novel;novel therapeutic intervention;patch clamp;Pathologic;Phospho-Specific Antibodies;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;Play;postsynaptic;Potassium Channel;Preparation;presynaptic;Presynaptic Terminals;prevent;Process;Property;Proteins;Proteomics;Reagent;recruit;Regulation;Role;Signal Transduction;Signaling Molecule;simulation;Site;Slice;Small Interfering RNA;sound;Sound Localization;Spinocerebellar Ataxias;Stimulus;Synapses;Synaptic Transmission;Synaptic Vesicles;TANK-binding kinase 1;Testing;trapezoid body;Vesicle;voltage

PROJECT_TITLE: Expression of Ion Channels in the Auditory System

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Regenerative Medicine

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: To meet the challenges in regenerating, repairing or replacing tissues that serve a mechanical function, the Biomechanics in Regenerative Medicine (BiRM) training program aims to provide holistic training to doctoral students in bioengineering to excel in both biomechanics of all relevant length scales and in regenerative biology. The combined strengths of the University of Pittsburgh, Carnegie Mellon University, the University of Pittsburgh Medical Center and the McGowan Institute for Regenerative Medicine make it a unique place for a new generation workforce to be trained in order to meet the critical needs for improving existing as well as to develop novel and advanced therapies in regenerative medicine.

PI_NAMEs: VORP, DAVID ALAN (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TITLE: Biomechanics in Regenerative Medicine (BiRM) Training Program


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: Columbus

ORG_DEPT: GENETICS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Rapid molecular oscillators are important for generating segmental pattern during development, for promoting heterogeneous responses in neural stem cells, and for biasing embryonic stem cells toward different cell fates. We propose to discover new oscillatory genes, uncover their biological functions, and dissect the regulatory mechanisms that govern their oscillatory expression. We propose that our discoveries will impact studies in fields as diverse as stem cell biology, tissue engineering, and even cancer cell biology.

PI_NAMEs: AMACHER, SHARON L (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: 3' Untranslated Regions;Arabidopsis;Binding;Bioinformatics;Biological Pacemakers;Biological Process;biological systems;cancer cell;Candidate Disease Gene;Cells;Cellular biology;Clustered Regularly Interspaced Short Palindromic Repeats;cytokine;Cytoplasm;Development;Elements;Embryo;Embryonic Development;embryonic stem cell;Ensure;Environment;experimental study;Feedback;Fibroblast Growth Factor;Gamma Rays;Gene Expression;Gene Family;Genes;Genetic;Genetic Transcription;Hour;Human;Impairment;In Situ Hybridization;In Vitro;knock-down;Knock-out;Lateral;Length;Mediating;Mesoderm;Mesoderm Cell;Metabolic;Modeling;Molecular;Molting;Mus;mutant;Mutate;nerve stem cell;NF-kappa B;notch protein;Nuclear;Pathway interactions;Pattern;Periodicals;Periodicity;Play;Poly(A) Tail;polysome profiling;Post-Transcriptional Regulation;posttranscriptional;Process;Proteins;Regulation;Regulatory Element;Reporter;Resolution;response;Ribosomes;RNA Binding;Role;Segmentation Clock Pathway;Signal Transduction;Somites;somitogenesis;Starvation;stem cell biology;Stem cell pluripotency;stem cells;System;Time;Tissue Engineering;Tissues;TP53 gene;Trans-Activators;Transcript;transcription factor;Transcription Repressor;transcriptome;Transgenic Organisms;Translating;Translational Repression;Translations;Vertebrates;Work;Yeasts;Zebrafish

PROJECT_TITLE: Developmental regulation of oscillatory expression

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: OTOLARYNGOLOGY

PHR: Project Narrative Cocaine use disorders (CUD) are consistently associated with disrupted processing of non-drug stimuli to dysregulate behavior outside the context of cocaine seeking. Deficits in fundamental behavioral functions such as learning and decision making negatively affect the lives of individuals suffering from CUD, and the severity of these symptoms is strongly associated with disease progression and treatment outcomes. CUDs are at a unique disadvantage when it comes to treatment with no FDA approved therapies, necessitating further research on stimulant use neural dysregulation to produce novel interventions.

PI_NAMEs: GABRIEL, STEPHANIE ANN CAJIGAS (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: addiction;Adenoviruses;Affect;Air;Amygdaloid structure;Animal Model;Animals;Area;Association Learning;Aversive Stimulus;awake;Basic Science;Behavior;Behavior Control;Behavioral;behavioral impairment;behavioral response;Brain;Calcium;calcium indicator;Cell Nucleus;clinical practice;Clinical Sciences;Cocaine;cocaine exposure;cocaine seeking;cocaine self-administration;cocaine use;Cocaine use disorder;Complex;Cues;Decision Making;Desire for food;Development;Disadvantaged;Disease Progression;doctoral student;Drug Exposure;Exhibits;experience;FDA approved;Fiber;Fiber Optics;Future;Glutamates;Goals;Hippocampus;human model;Image;Impairment;Implant;Individual;individualized medicine;insight;Intervention;Laboratories;Learning;Link;maladaptive behavior;Medial;Mediating;Mediator;Mentors;neural;Neurobiology;Neurons;non-drug;novel;Nucleus Accumbens;Optics;Outcome;Pathway interactions;Patient Care;Patients;Pattern;Pharmaceutical Preparations;Photometry;Physicians;Population Projection;Prefrontal Cortex;Preparation;Process;Psychiatry;recruit;Research;response;Response to stimulus physiology;Rewards;Scientist;Severities;Signal Transduction;Site;stimulant use;stimulant use disorder;Stimulus;stimulus processing;Sucrose;Symptoms;Synapses;Technology;Training;Treatment outcome;Viral

PROJECT_TITLE: Accumbal integration of brain wide glutamatergic inputs and their dysregulation by cocaine self-administration


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative We seek to validate, calibrate, and translate restricted spectrum imaging (RSI-MRI) across vendors to asses in the detection of clinically significant prostate cancer. RSI-MRI is a novel sequence protocol with software post- processing accomplished along with standard of care MRI to improve the quality of prostate MRI imaging. The research has the potential to revolutionize prostate cancer diagnosis and monitoring by providing a non-invasive imaging biomarker with the ability to improve diagnostic accuracy and risk stratification across MRI scanners.

PI_NAMEs: LISS, MICHAEL ANDRE (contact);WHITE, NATHAN SCOTT

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: Academic support;Affect;Amendment;Anatomy;Area;Area Under Curve;arm;Biological Markers;biomarker performance;Biopsy;Biopsy Specimen;Calibration;California;cancer biomarkers;cancer cell;cancer diagnosis;Characteristics;Clinical;Clinical Assessment Tool;clinical diagnosis;clinical practice;clinical risk;Clinical Trials;clinically significant;Code;Color;Computer software;Data;Decision Making;Detection;Diagnosis;diagnostic accuracy;diagnostic value;Diffusion;Diffusion Magnetic Resonance Imaging;diffusion weighted;Digital Imaging and Communications in Medicine;Disease;Early Diagnosis;Enrollment;Equipment;FDA approved;Health;High-Risk Cancer;Housing;Image;Image Analysis;imaging biomarker;imaging modality;Imaging technology;improved;in vivo;indexing;Indolent;industry partner;Inflammation;Information Systems;innovation;Institution;interest;Intravenous;intravenous injection;Investigation;Lesion;Location;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Magnetism;Malignant neoplasm of prostate;Malignant Neoplasms;manufacture;Manufacturer;Maps;Measurement;Measures;Medicine;men;Methods;Modality;Modeling;Molds;molecular marker;Monitor;non-invasive imaging;novel;Output;Patients;Pharmaceutical Preparations;Predictive Value;Process;prospective;Prostate;prostate biopsy;prostate cancer cell;prostate cancer risk;Prostatectomy;Protocols documentation;Publishing;radiologist;Radiology Specialty;randomized, clinical trials;Reader;Receiver Operating Characteristics;Reporting;Research;Restriction Spectrum Imaging;risk stratification;Sampling;Sampling Errors;Scanning;Screening for Prostate Cancer;Serum;side effect;Signal Transduction;Source;Specificity;standard of care;Standardization;Statistical Data Interpretation;Structure;System;T2 weighted imaging;Techniques;Time;Tissues;Translating;Translations;tumor;Tumor Markers;ultrasound;United States;Urine;Validation;Variant;Vendor;Water;Work

PROJECT_TITLE: Validation, Calibration, and Translation of Restriction Spectrum Imaging Signal Maps to enhance MRI diagnostic capabilities in Prostate Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-S(57)R]


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Over the past two years my laboratory has developed a real-time biomarker for opioid drugs that could be used to provide more precise titration of opioid drugs and for drug discovery applications. In this project we propose to investigate the mechanisms underlying this biomarker and develop further translational science to support clinical applications.

PI_NAMEs: PURDON, PATRICK L. (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Acute;Adjuvant;Anesthesia procedures;Anesthetics;Attenuated;Basic Science;behavior measurement;Behavioral;Biological Markers;Brain;Caring;Chronic;chronic pain;Clinical;clinical application;Clinical Research;clinical translation;Data;density;Dependence;Development;Dopamine Antagonists;drug development;drug discovery;Electroencephalography;Fentanyl;fentanyl use;Formulation;Frequencies;Funding;General Anesthesia;Human;improved;individual patient;Intensive Care;Knowledge;Laboratories;Managed Care;Measures;Methods;Monitor;Names;National Institute of Drug Abuse;neurophysiology;Nociception;novel;novel therapeutics;Nurses;Operating Rooms;Operative Surgical Procedures;Opiate Addiction;Opioid;opioid abuse;Opioid Analgesics;opioid epidemic;opioid mortality;opioid sparing;opioid use;Overdose;overdose death;Pain;Pain management;Patients;Perioperative;Pharmaceutical Preparations;Physiological;Play;Postoperative Pain;prescription opioid;Property;Public Health;Reporting;Research Project Grants;Rewards;Role;Sedation procedure;source localization;temporal measurement;Time;Titrations;tool;Translational Research;Unconscious State;Ventilatory Depression

PROJECT_TITLE: Characterizing brain dynamic biomarkers of fentanyl using intracranial and high-density electroencephalogram in humans

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Inflammation is a basic immunological mechanism that helps to protect the host from injury and infection under normal physiological conditions. Pathological inflammation is a pervasive component in many human diseases including chronic infections, autoimmune diseases, vascular and neurological diseases, and cancer. Training a new generation of the brightest scientists in the study of immunology and inflammation will facilitate the understanding and ultimately treatment of multiple diseases of public health importance.

PI_NAMEs: SCHWAB, SUSAN RUTH (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TITLE: Training Program in Immunology and Inflammation

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ORG_CITY: CAMBRIDGE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative Myelin is a lipid-rich membrane produced by specialized cells called oligodendrocytes, which wraps the axons of neurons and increases the velocity of action potentials, thereby enhancing the efficiency of long-distance neuronal transmission. Disrupted myelination contributes to many debilitating neurological disorders, including multiple sclerosis and schizophrenia. We propose to answer fundamental questions regarding the mechanisms that control cell-type specific myelination, and test hypothesis on how “attractive” and “repulsive” cues, expressed by neuronal subtypes and on axon compartments, dynamically regulate neuronal interactions with oligodendrocytes.

PI_NAMEs: ARLOTTA, PAOLA  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Action Potentials;Adult;Affect;Axon;Binding;Brain;Candidate Disease Gene;candidate identification;cell type;Cells;Cellular biology;Central Nervous System;Cerebral cortex;Classification;Code;Communication;Complex;CRISPR/Cas technology;Cues;Cuprizone;Data;Demyelinations;design;Development;Developmental Biology;Evolution;experience;experimental study;Functional disorder;Gap Junctions;Genetic;Goals;in vivo evaluation;in vivo two-photon imaging;Interneurons;Investigation;Knowledge;Label;Ligands;Lipids;Location;Maps;Mediating;Membrane;Membrane Proteins;Modeling;Molecular;Molecular Profiling;Monitor;Morphology;mRNA Differential Displays;Multiple Sclerosis;Myelin;Myelin Sheath;myelination;Natural regeneration;Neocortex;Nervous System Disorder;neural circuit;Neurons;neurotransmission;Oligodendroglia;Parvalbumins;Pathologic;Pattern;Population;Positioning Attribute;Process;Protocols documentation;Ranvier's Nodes;receptor;Regulation;remyelination;Reporting;Repression;Resolution;response;Role;Schizophrenia;Signal Transduction;Signaling Molecule;Somatostatin;Structure;Surface;Synapses;Testing;Therapeutic;Thick;transcriptome;transcriptomics;Vasoactive Intestinal Peptide;virtual;Work

PROJECT_TITLE: Neuron-oligodendrocyte communication underlying myelin distribution in the neocortex

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Although RNAs drive a diverse array of cellular functions throughout biology, and are causally dysregulated in many human pathologies, probing the interactions RNA molecules make within cells remains technically challenging. To address this technological gap, in this proposal we will develop a robust and straightforward method for identifying the proteins, RNAs, and genomic loci that interact with a target RNA, that can be easily applied to different RNAs and cellular states. This technology will transform our understanding of RNA interactions across numerous biological settings and diseases, paving the way for paradigm-shifting discoveries in cell biology, and revealing novel RNA-based therapeutic targets.

PI_NAMEs: SHECHNER, DAVID MICHAEL (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;Adopted;Affinity;Antisense Oligonucleotides;Architecture;Binding;Biochemical;Biological;biological adaptation to stress;Biological Models;Biology;Biotinylation;Cell Culture Techniques;cell fixing;Cell Line;Cell Nucleolus;Cell Physiology;cell type;Cells;Cellular biology;Chemicals;Clinical;clinically relevant;Code;Communication;Complex;Data;design;Development;Disease;DNA;DNA sequencing;Embryonic Development;Engineering;Enzymes;Exhibits;experimental study;field study;Fractionation;Gene Expression;genetic manipulation;genomic locus;Genomics;Goals;human disease;Human Pathology;Image;In Situ;Individual;Infection;Interphase Cell;Kinetics;Laboratories;Length;Malignant Neoplasms;Mammalian Cell;Maps;Membrane;Messenger RNA;Metabolic;Methods;Modeling;Molecular;molecular assembly/self assembly;Monitor;multiple omics;Neurodegenerative Disorders;neurotransmission;Noise;novel;Nuclear;Nucleic Acid Probes;Oligonucleotides;Organelles;Organism;Play;portability;programs;Proteins;Proteome;Proteomics;Protocols documentation;recruit;Resolution;Resources;response;RNA;RNA analysis;RNA Probes;RNA-Protein Interaction;Role;rRNA Precursor;Sampling;scaffold;single molecule;Specificity;Streptavidin;Structure;Techniques;Technology;Testing;therapeutic RNA;therapeutic target;tool;transcriptome;transcriptome sequencing;Untranslated RNA;Viral Pathogenesis;X Inactivation

PROJECT_TITLE: Oligonucleotide-directed in situ proximity biotinylation: a unified method for mapping RNA-interacting proteomes, transcriptomes and genomic loci within intact cells.

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Lung;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pneumonia and Influenza;Pregnancy;Prevention;Vaccine Related;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE This proposal will determine the impact of an acute influenza A virus infection during pregnancy on maternal and placental antiviral immune responses to elucidate the pathogenesis of severe lung injury in a highly relevant nonhuman primate model. These studies are critical for IAV pandemic preparedness to enable testing of efficacy and safety of new universal influenza vaccines.

PI_NAMEs: ADAMS WALDORF, KRISTINA M. (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Acute;adaptive immune response;adverse pregnancy outcome;Animal Model;Animals;Anti-viral Response;Automobile Driving;Autopsy;Blood;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Cessation of life;chemokine;Clinical;Coupled;cytokine;Data;Development;Disease;Disease susceptibility;DNA;economic cost;efficacy testing;fetal;Fetus;Flow Cytometry;Frequencies;Future;Gene Expression;gene network;Genes;Genetic Transcription;Gestational Age;Heart;Histopathology;Host Defense;Human;IL17 gene;Immune;immune activation;Immune response;immunopathology;Impairment;Infection;Inflammasome;Inflammatory;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;influenzavirus;Injury;innate immune pathways;Innate Immune Response;Integration Host Factors;Interferons;interleukin-23;Link;Lung;Lung Diseases;lung injury;Lung Lavage Fluid;Macaca nemestrina;Maps;Maternal Mortality;maternal risk;Messenger RNA;Modeling;Morbidity - disease rate;mouse model;Myocarditis;National Institute of Allergy and Infectious Disease;nonhuman primate;organ injury;pandemic preparedness;pandemic virus;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Phenotype;phenotypic data;Placenta;Pneumonia;Pregnancy;pregnant;Pregnant Women;Premature Birth;prevent;Quantitative Reverse Transcriptase PCR;Resolution;response;Risk;Safety;safety testing;Sampling;single-cell RNA sequencing;Site;Stains;stillbirth;Strategic Planning;Structure of parenchyma of lung;T cell response;Testing;Texas;Time;Tissues;transcription factor;transcriptome;transcriptome sequencing;universal influenza vaccine;Vaccination;vaccine platform;Vaccines;Villous;Viral;Viral Load result;Virus Diseases;Vulnerable Populations;white matter injury;Whole Blood

PROJECT_TITLE: Influenza pathogenesis in pregnancy

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: Project Narrative This renewal application proposes training postdoctoral candidates and cognitive neurology fellows researching Brain Aging and Neurodegenerative Diseases at NYU Langone Health (NYULH). There is a critical need to train the next generation of MD and PhD researchers to investigate disorders of brain aging, develop new therapeutics and interventions, and translate these findings from bench to bedside to the community. This training program is housed in the Center for Cognitive Neurology, a school-wide, extradepartmental, multidisciplinary program designed to foster collaborative, translational research at NYULH and will train the next generation of research and clinician scientists in rigorous methodologies and innovative approaches to advance the field of brain aging and neurodegeneration

PI_NAMEs: SCHARFMAN, HELEN E;WISNIEWSKI, THOMAS M (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Alzheimer's Disease;Neurodegenerative Disorders;Postdoctoral Fellow;Research Training

PROJECT_TITLE: Postdoctoral Research Training in Alzheimer's Disease and Related Neurodegenerative Disorders


NIH_SPENDING_CATS: Aging

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Regardless of whether they choose careers in research, medical education or clinical care, medical students who participate in aging research are more likely to pursue careers in aging. The David Geffen School of Medicine at the University of California Los Angeles (UCLA) is partnering with the University of California San Francisco School of Medicine (UCSF), and the University of Washington (UW) to seek continued support for a formal 8-12 week program of training in aging research as well as clinical exposure to aging for medical students.

PI_NAMEs: LEE, CATHY  (contact);WANAGAT, JONATHAN

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Address;Aging;Area;California;career;Clinical;clinical care;Collaborations;Communities;dementia care;Educational process of instructing;Elderly;experience;Faculty;Fostering;Foundations;Funding;Geriatrics;innovation;Institution;interest;intergenerational;Los Angeles;medical schools;Medical Students;Mentors;Methods;Mission;Monitor;Nonprofit Organizations;Palliative Care;Patients;Physicians;programs;Research;Research Priority;Research Training;responsible research conduct;San Francisco;Scientist;Site;skills;student training;Students;Training;Training Programs;Universities;Washington

PROJECT_TITLE: UCLA Medical Student Training in Aging Research (MSTAR) Program


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Glutamate-activated NMDA receptors mediate a Ca2+-permeable component of excitatory synaptic transmission in the brain that is involved in learning, memory, and development. NMDA receptors have been implicated in a wide range of neurological conditions, and there is intense interest in the development of allosteric modulators as new therapeutic treatments for neurological disease. This research program is designed to address all key aspects of glutamate receptor signaling, including the structural underpinnings of function, genetic variation as it relates to rare disease and risk factors, identification of therapeutically-relevant molecules that can be used as probes to develop novel treatment strategies, and the fundamental process of synaptic transmission.

PI_NAMEs: TRAYNELIS, STEPHEN F (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Address;Agonist;Alzheimer's Disease;Binding;Binding Sites;Biology;Brain;Cations;Chemistry;Clinical;Collaborations;Corpus striatum structure;Cryoelectron Microscopy;Crystallography;design;Development;Disease;disorder risk;Electrophysiology (science);Epilepsy;Evaluation;experimental study;Gene Frequency;Genes;Genetic;genetic analysis;Genetic Variation;Genome;Glutamate Receptor;Glutamates;Human;improved;in vivo;in vivo Model;Individual;insight;interest;Ion Channel;Ischemia;Learning;Mediating;Memory;Molecular;Mutation;N-Methyl-D-Aspartate Receptors;Nervous System Disorder;Neurologic;Neuroprotective Agents;NMDA receptor A1;novel;novel therapeutic intervention;novel therapeutics;Parkinson Disease;Penetration;Permeability;Pharmaceutical Chemistry;pharmacologic;Population;postsynaptic;precision medicine;Probability;Process;programs;Property;Protein Region;Rare Diseases;rare variant;receptor;receptor function;Receptor Signaling;Research;Risk Factors;Robotics;Role;side effect;Site;Solubility;Stroke;structural biology;Structure;synaptic function;Synaptic Transmission;Thalamic structure;Therapeutic;tool;treatment strategy;Variant

PROJECT_TITLE: Glutamate receptors and human neurological disease


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Recent studies have identified that proteins that bind RNA to regulate RNA translation, stability or splicing, play key roles in human cancer. We recently identified a group of such RNA binding proteins (RBPs) that are required for the survival of acute myeloid leukemia (AML), a deadly form of cancer in great need of improved therapy. In this proposal we aim to understand the role of one such protein called RBM39, which is a putative, novel, and exciting new AML drug target.

PI_NAMEs: ABDEL-WAHAB, OMAR  (contact);AIFANTIS, IANNIS

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Ablation;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adaptor Signaling Protein;Address;Adult;anti-cancer;Binding;Biological;cancer cell;Cancer cell line;cancer survival;CD34 gene;Cell Line;Cell Physiology;cell type;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;conditional knockout;CRISPR/Cas technology;Data;Dependence;Disease;Drug Targeting;Evaluation;Excision;Exons;Genetic;Genetic Engineering;Genetic Models;Genetic Transcription;Growth;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Histologic;HOXA9 gene;Human;Impairment;improved;In Vitro;in vivo;insight;Introns;Knockout Mice;leukemia;leukemia initiating cell;Link;Liquid substance;loss of function;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mediating;member;Messenger RNA;Methods;Modeling;mouse model;mutant;Mutation;Non-Malignant;novel;novel strategies;Nucleosomes;Oncogenic;overexpression;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Physiological;Play;Population;Protein Splicing;Proteins;Proteomics;Recurrence;Repression;RNA;RNA analysis;RNA Binding;RNA Recognition Motif;RNA Splicing;RNA-Binding Proteins;Role;Sampling;Solid;Spliceosomes;stem;stem cell population;Sulfonamides;Time;Tissues;Transcription Elongation;Translations;treatment strategy;tumorigenesis;ubiquitin ligase;Up-Regulation

PROJECT_TITLE: Targeting an RNA Binding Protein Network in Acute Myeloid Leukemia

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pain Research;Patient Safety;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

PHR: We will develop and evaluate an Embodied Conversational Agent – Patient-Reported Outcome (ECA-PRO) smartphone system that engages patients with interactive communication and empathy, while delivering standard PROs in a way that minimizes missing data and enables user- friendly visual sharing of results. The ECA-PRO system will create a strong foundation for PRO- based clinical decision-making. This novel system will be tested as a means to monitor symptoms and adverse events in patients with cancer receiving chemo- and/or radiation therapy, and to monitor medication adherence in patients taking oral medication for breast cancer.

PI_NAMEs: BICKMORE, TIMOTHY W.;GRIFFITH, JAMES WILLIAM;PAASCHE-ORLOW, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: JENSEN, ROXANNE ELAINE

PROJECT_TERMS: Adherence;Adjuvant;Adverse event;Aftercare;Antineoplastic Agents;Anxiety;Aromatase Inhibitors;Behavior;Behavior Therapy;Behavioral Medicine;Breast Cancer therapy;cancer therapy;Cellular Phone;chatbot;chemotherapy;Chemotherapy and/or radiation;Clinical;Clinical assessments;clinical decision-making;clinically relevant;Common Terminology Criteria for Adverse Events;Communication;Communication Methods;computer science;Computers;cost;Cues;Data;Data Collection;data visualization;design;Discipline;Disease;Electronic Health Record;Empathy;Evolution;Fatigue;field study;Foundations;gastrointestinal;gaze;Gestures;Hand;Head and Neck Cancer;health assessment;health literacy;health related quality of life;hormone therapy;Impaired cognition;improved;Individual;individual patient;Information Systems;Instruction;Interactive Communication;Internet;low health literacy;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Measures;medication compliance;Medicine;Mental Depression;Monitor;Moods;non-verbal;novel;older patient;Oral;Pain;Pain interference;Paper;Participant;patient engagement;Patient Outcomes Assessments;Patients;Performance;Pharmaceutical Preparations;Physical Function;Population Intervention;Process;Psychometrics;Quality of life;Radiation therapy;Randomized;receptor;Research;satisfaction;Schedule;Scheme;screening;Spanish;Spanish/English;substance use;Surveys;Symptoms;System;Tamoxifen;Testing;Time;time use;tool;user-friendly;Validity and Reliability;Visual;Visualization;Visualization software;Voice;Work;Writing

PROJECT_TITLE: Improving PRO Interpretation at the Individual Level for Patients with Cancer using Conversational Agents and Data Visualization

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE This application proposes a new training program in Functional Genomics. Our program will provide predoctoral trainees with the conceptual and technical foundation for developing independent careers in basic and translational genetics and genomics. The training supports the overall mission of NIGMS to promote research that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment and prevention.

PI_NAMEs: HARRIS, ANN  (contact);LAFRAMBOISE, THOMAS LOUIS

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: functional genomics;Training Programs

PROJECT_TITLE: Functional Genomics Training Program (FGTP)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Lung;Physical Injury - Accidents and Adverse Effects;Pulmonary Fibrosis;Regenerative Medicine

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: The UCLA-CMCR has an effective infrastructure for the discovery and development of novel mitigators of acute radiation syndromes (ARS); both hematological (H-ARS) and intestinal (GI- ARS), later radiation pneumonitis and lung fibrosis, and the delayed effects of acute radiation exposure (DEARE) that result in multiple organ disease (MOD) and shorten life span. We have identified numerous mitigators of radiation syndromes and several have been optimized and entered further development. Here, we focus on our existing agents that target highly conserved, developmental signaling pathways and have broad activity against radiation damage to multiple tissues, and explore the potential of these pathways to provide new agents and targets for mitigation of radiation damage.

PI_NAMEs: CHUTE, JOHN P (contact)

PROGRAM_OFFICER_NAME: VEDAMONY, MERRILINE M

PROJECT_TERMS: Academia;Acute;Affect;Animal Model;Cells;chemical synthesis;Chronic;cohesion;Development;Disease;Dose;Drug Delivery Systems;drug development;Drug Kinetics;Drug Modelings;Education;Ensure;Exposure to;FDA approved;Formulation;Germ-Free;Gnotobiotic;Goals;healing;Hematology;Hematopoietic;Homeostasis;Immune system;improved;Industry;Inflammation;Infrastructure;Intellectual Property;interest;Intestines;life span;member;Modeling;Morbidity - disease rate;mortality;Mouse Strains;National Institute of Allergy and Infectious Disease;Natural regeneration;New Agents;novel;Organ;Oxidative Stress;Pathway interactions;Pharmaceutical Preparations;Pilot Projects;Polypharmacy;programs;Pulmonary Fibrosis;Radiation;Radiation Dose Unit;Radiation exposure;Radiation induced damage;Radiation Injuries;radiation mitigation;radiation mitigator;Radiation Pneumonitis;Radiation Syndromes;Radiation Toxicity;Research Personnel;response;Role;Services;Signal Pathway;Solubility;Structure;Syndrome;targeted agent;Testing;Tissues;Vascular regeneration;Vascular remodeling

PROJECT_TITLE: Mitigation of Radiation Injury via Vascular Regeneration and Remodeling


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative: Childhood obesity is a major public health problem that disproportionately affects low- income Hispanic children. Hispanic families, especially Spanish Speakers, have been under-represented in studies of childhood obesity treatment, and existing interventions have not demonstrated effectiveness for this group. The goal of this project is to evaluate a novel family-inclusive childhood obesity treatment program designed for low-income and Hispanic, including Spanish Speaking families.

PI_NAMEs: HAEMER, MATTHEW A. (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 16 year old;Academy;active control;Address;Adoption;Adult;Affect;age group;Behavior Therapy;Body mass index;cardiometabolism;Caregivers;Caring;Child;Clinic;Clinical;clinically significant;community clinic;community engaged research;community organizations;community partnership;compare effectiveness;cooking;cost;Counseling;Data;Dedications;design;Development;Diabetes Mellitus;Disparity;Dissemination and Implementation;Dose;Eating Behavior;Educational Curriculum;effective intervention;Effectiveness;effectiveness testing;effectiveness/implementation trial;Enrollment;evidence base;Exclusion;experience;Family;fitness;food insecurity;food security;Foundations;Funding;Goals;group intervention;Health;health disparity;Health Educators;healthy weight;High-Income Populations;Hispanic;Hispanic Populations;Home;implementation evaluation;implementation outcomes;implementation process;implementation strategy;improved;Insurance;Intervention;Lead;Linguistics;Low income;Low Income Population;lower income families;Maintenance;Measures;Medicaid;Mentored Patient-Oriented Research Career Development Award;mortality;Non obese;Not Hispanic or Latino;novel;Obesity;obesity in children;obesity prevention;obesity treatment;Overweight;Parents;payment;Pediatrics;Pilot Projects;Population;Population Intervention;Preparation;prevent;Prevention;Primary Care;primary care clinic;primary care provider;programs;prospective;Protocols documentation;Public Health;Quality of life;Quasi-experiment;randomized controlled design;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recreation;Research;Research Personnel;safety net;scale up;Siblings;Spanish;Testing;therapy design;Training;treatment program;trend;United States Preventative Services Task Force;Waiting Lists;Weight maintenance regimen

PROJECT_TITLE: Family Inclusive Childhood Obesity Treatment designed for Low Income and Hispanic Families

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Mental Health;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE This project is aimed at understanding how the human brain encodes vibration information and how these representations are influenced by attention and multisensory processing. Our findings may inform the diagnosis and treatment of sensory, cognitive, or psychiatric disorders involving somatosensory deficits, such as in individuals with brain damage, autism, schizophrenia, and age-related cognitive impairments.

PI_NAMEs: YAU, JEFFREY M (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Acoustic Stimulation;Acoustics;Age-associated memory impairment;Alzheimer's Disease;Area;Attention;Auditory;Auditory area;auditory stimulus;autism spectrum disorder;Behavior;Brain;Brain Injuries;Brain region;Central Nervous System;Cognition;Cognition Disorders;Complex;Cues;Darkness;Data;Dedications;Diagnosis;Discontinuous Capillary;experience;experimental study;Fingers;Frequencies;Functional Magnetic Resonance Imaging;Hand;Hearing;Human;Individual;Investigation;Knowledge;Logic;Maximum Likelihood Estimate;Measures;Mental disorders;Modeling;Movement;multisensory;Neocortex;neural;neuroimaging;Participant;Perception;Peripheral;Population;Process;response;Running;Schizophrenia;selective attention;Sensory;sensory cortex;Sensory Disorders;sensory integration;Shapes;Signal Transduction;Silk;Skin;somatosensory;Somatosensory Cortex;sound;Stimulus;Stream;Structure;Surface;Surveys;System;Tactile;tactile stimulation;Testing;Texture;Time;tool;Touch sensation;vibration;vibration perception;visual stimulus

PROJECT_TITLE: Encoding and modulation of vibration representations in human neocortex

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Growth-arrested bacteria display a remarkable resilience to antibiotics and host immune defenses, thereby contributing to the growing burden of antimicrobial resistance. Uncovering the mechanisms used by bacteria to establish a long-term viable growth-arrested state in stressful situations such as during infection of immune cells can serve as a springboard to develop better antibiotics.

PI_NAMEs: HELAINE, SOPHIE  (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TITLE: The physiological activation and consequences of Toxin-Antitoxin systems in Salmonella

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The Advanced Training in Environmental Health Sciences program at UC Davis provides unique training in environmental health sciences (EHS) to predoctoral students to prepare them for diverse careers focused on the impacts of environmental factors on human health and disease. This program builds on existing interdisciplinary and collaborative research strengths at UC Davis, with vertical integration of studies at the molecular, cellular, organismal, and population levels directed toward understanding environmentally-induced disease. Trainees will receive a combination of didactic and experiential training to promote understanding of current and emerging concepts, controversies andtechnologies in environmental health, as well as a deep appreciation of responsible conduct of research, including rigor and reproducibility while working with diverse collaborators.

PI_NAMEs: VAN WINKLE, LAURA S (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Environmental Health;Training

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(T)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Arthritis and systemic autoimmune diseases afflict more than 40 million Americans with pain, diminished functional capacity, and for many a shortened life span. To prepare national leaders dedicated to improving the lives and futures of those afflicted, this program provides advanced clinical and laboratory research training to physicians and scientists specifically focused on these diseases. Training will be accomplished through strong mentorship by experts in the field, specialized didactics, and substantial research projects.

PI_NAMEs: BUYON, JILL P (contact);SCHER, JOSE U.

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Basic Science;Clinical Research;Research Training;Rheumatology

PROJECT_TITLE: Translational Basic and Clinical Research Training in Rheumatology


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Pediatric;Prevention

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: PROJECT NARRATIVE A striking 83% of adolescents and young adults (AYA) with type 1 diabetes (T1D) have suboptimal glycemic control, placing them at risk for acute and chronic complications. Rigorous research investigating strategies to enhance T1D management in AYAs, prior to the transition from pediatric to adult healthcare, is needed to optimize their health and adequately prepare them for the transition to independence. The proposed intervention includes all key stakeholders (AYAs, parents, and providers) in a multisystem intervention, and is designed to enhance T1D self-management and increase AYAs’ readiness for transition to adult healthcare during this critical developmental period, thus has the potential to inform clinical practice guidelines.

PI_NAMEs: CACCAVALE, LAURA JEAN (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: Acute;Address;Adherence;Adolescent and Young Adult;Adult;Age;aged;Area;arm;Award;Behavior Therapy;Behavioral;behavioral outcome;Biological;career development;Caregivers;Caring;Certification;Child Rearing;Childhood;Chronic;Chronic Disease;Clinic;Clinic Visits;Clinical;clinical care;Clinical Practice Guideline;clinically significant;Communication;Complications of Diabetes Mellitus;Conflict (Psychology);Coupled;critical developmental period;Data;demographics;design;Deterioration;Development;Development Plans;diabetes distress;diabetes management;Diabetes Mellitus;diabetes self-management;Dose;Education;Eligibility Determination;Endocrinology;evidence base;Evidence based intervention;experience;Family;follow-up;Future;Generations;glycemic control;Glycosylated hemoglobin A;Goals;Health;Healthcare;high risk;Hospitals;Hybrids;improved;individual patient;Insulin-Dependent Diabetes Mellitus;Intervention;Interview;Learning;Mentorship;Modeling;Modification;Morbidity - disease rate;Nature;Outcome;parental involvement;Parents;Participant;Patient Education;patient portal;Patients;Persons;Play;Preparation;primary endpoint;primary outcome;Process;programs;Protocols documentation;Provider;provider communication;psychoeducation;Quality of life;Randomized;randomized controlled design;Randomized, Controlled Trials;Readiness;Recommendation;recruit;Reporting;Research;Research Personnel;Risk;Role;satisfaction;Schedule;Science;Self Management;Signal Transduction;skills;social;Specialist;System;technology platform;Testing;Training;treatment as usual;trial design;video module;virtual;virtual visit;Visit;Work;young adult;Youth

PROJECT_TITLE: Improving Transition Care for Adolescents and Young Adults with Type 1 Diabetes: A Randomized Controlled Trial of SHIFT2

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK(M1)-1-B]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Narrative Infections caused by Toxoplasma gondii remain a significant cause of human disease in immunocompromised patients, and wide spread chronic infections raise the risk of complications in healthy people should their immune system decline. The immediate goal of our studies is to define molecular pathways that control the entry and exit of the parasite from its host cell. The long-term goal of these studies is to provide fundamental knowledge as a foundation for future development of new therapeutic interventions against toxoplasmosis.

PI_NAMEs: SIBLEY, L. DAVID (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Actins;active control;Adenylate Cyclase;Adhesives;Auxins;Binding;Biotin;Calcium;Calcium Signaling;calcium-dependent protein kinase;candidate identification;Cell membrane;Cells;chronic infection;Code;Consumption;CRISPR/Cas technology;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cyclic GMP;Cyclic GMP-Dependent Protein Kinases;Data;design;Development;Dominant-Negative Mutation;Down-Regulation;Equilibrium;extracellular;Fostering;Foundations;Future;Genetic Transcription;Goals;human disease;Immune system;Immunocompromised Host;Impairment;In Vitro;in vitro activity;in vivo;Individual;Infection;inhibitor;Invaded;knock-down;Knock-out;Knowledge;Label;Ligation;Lytic Phase;Mass Spectrum Analysis;Mediating;Membrane;Molecular;Motility;Motor;mutant;Myosin ATPase;novel therapeutic intervention;Parasite Control;Parasites;Pathway interactions;permissiveness;Persons;Phenotype;phosphoproteomics;phosphoric diester hydrolase;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;Play;premature;prevent;Process;Production;protein degradation;Protein Isoforms;protein kinase A kinase;Proteins;Regulation;Risk;Role;Structure;Testing;therapeutic development;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;validation studies

PROJECT_TITLE: Regulation of host cell egress by Toxoplasma gondii

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-H(02)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Brown University, the University of Pittsburgh and Boston University, together with 8 health system/health organization partners, are combining expertise and resources to create LeaRRN: the Learning Health Systems Rehabilitation Research Network. LeaRRN’s mission is to improve the quality, outcomes and value of rehabilitation care by fostering stakeholder-partnered research within and across learning health systems.

PI_NAMEs: RESNIK, LINDA J. (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Address;Administrator;Adoption;Boston;care delivery;Caring;Clinic;Collaborations;Communities;Competence;cost;Data;Data Science;design;effective intervention;Electronic Health Record;Ensure;evidence base;Evidence based practice;experience;Faculty;Fostering;Funding;health organization;Health Services Research;Health system;Healthcare;Healthcare Systems;implementation science;improved;Incubators;Informatics;Infrastructure;innovation;interest;Knowledge;knowledge repository;Lead;Leadership;Learning;Mentors;Methodology;Mission;Modeling;Needs Assessment;next generation;Outcome;patient oriented;Patients;payment;Performance;Pilot Projects;Policy Maker;pressure;Process;Provider;Quality of Care;Rehabilitation Outcome;rehabilitation research;rehabilitation service;Rehabilitation therapy;rehabilitative care;Research;Research Ethics;Research Methodology;Research Personnel;Research Support;Resources;scale up;Science;sound;System;systems research;technique development;Time;Training;Universities


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Services;Physical Rehabilitation;Rehabilitation

PI_NAMEs: SHIREMAN, THERESA I. (contact)

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;Area;Awareness;Back;Bioinformatics;Biological Models;Boston;Clinical;Collaborations;Communities;Competence;Consultations;Data;Data Analyses;data to knowledge;Development;didactic education;Discipline;Dissemination and Implementation;education resources;Educational workshop;Ensure;Event;evidence base;Evidence based practice;Faculty;feeding;Fostering;Glean;health economics;Health system;implementation science;improved;innovation;Institution;Internet;Knowledge;Learning;Link;Medical;member;multimodality;online resource;Online Systems;Patient-Focused Outcomes;Performance;Persons;Printing;Process;Quality of Care;rehabilitation research;Rehabilitation therapy;rehabilitative care;Research;Research Methodology;Research Personnel;Resources;Scientist;Services;skills;symposium;systems research;Testing;Training;Training Activity;Training and Education;Universities;Update;webinar

PROJECT_TITLE: LeaRRN: the Learning Health Systems Rehabilitation Research Network


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Physical Rehabilitation;Rehabilitation

ORG_CITY: BALTIMORE

ORG_NAME: INFINITE BIOMEDICAL TECHNOLOGIES, LLC

ORG_STATE: MD

PHR: PROJECT NARRATIVE Dexterous prosthetic hands have the potential to greatly increase quality of life for upper limb amputees. Unfortunately, complicated and outdated control methods limit the potential that the user can access. In this project, we will develop and launch Glide, a novel controller that enables prostheses with greater function and more intuitive control. It is our hope that this will increase the ability of amputees to live independent lives and to work productively.

PI_NAMEs: KALIKI, RAHUL REDDY (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Affect;Amputees;Architecture;Artificial Arm;Calibration;Caring;Clinical;clinical care;Clinical Research;clinically relevant;commercialization;Data;design;Development;Devices;Documentation;Electrodes;Engineering;Ensure;evidence base;experience;Experimental Designs;fabrication;functional outcomes;Goals;grasp;Healthcare;home test;improved;Individual;individual patient;innovation;Intuition;Joystick;limb loss;Limb Prosthesis;Location;Marketing;Measurement;Measures;Medical;Medical Device;Methods;Motion;Movement;myoelectric control;Myoelectric prosthesis;novel;Occupational Therapist;Outcome;Participant;Patients;Pattern Recognition;Performance;Phase;Positioning Attribute;Production;Productivity;Prosthesis;prosthesis control;prosthetic hand;Prosthetic rehabilitation;Provider;Quality of life;Questionnaires;Radial;Rehabilitation Outcome;Rehabilitation therapy;rehabilitative care;Research;residual limb;satisfaction;Specific qualifier value;System;Technology;Testing;United States Food and Drug Administration;Upper Extremity;usability;Validation;vector;verification and validation;Work

PROJECT_TITLE: Regulatory clearance of the Glide Control Strategy for Upper Limb Prostheses


NIH_SPENDING_CATS: Clinical Research;Health Services;Physical Rehabilitation;Rehabilitation

PI_NAMEs: FREBURGER, JANET KUES (contact)

PROJECT_TERMS: Acceleration;Address;Administrator;American;Area;Assisted Living Facilities;Boston;care delivery;Clinic;Complex;Continuity of Patient Care;data infrastructure;Discipline;Environment;experience;Faculty;faculty mentor;Fostering;Foundations;Funding;Funding Mechanisms;Health;Health Care Research;health care service organization;Health Priorities;Health system;Healthcare;Healthcare Systems;Home Care Services;improved;Individual;innovation;insight;Knowledge;Laboratories;Learning;Medical center;Medicine;Mentors;novel;Pilot Projects;Population;Positioning Attribute;Process;Productivity;programs;rehabilitation research;Rehabilitation therapy;rehabilitative care;Research;Research Methodology;Research Personnel;research to practice;Resources;Scholars Program;System;systems research;Work

PROJECT_TITLE: LEARRN: Mentored Collaborative Opportunities Component


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: NARRATIVE New drugs that target metabolic pathways have shown promise for the treatment of cancer, but the benefits of these drugs have been restricted to rare patients whose cancers have mutations in metabolic enzymes. We have identified a metabolic pathway whereby normal stem cells and almost all cancer cells produce a metabolite called L-2-hydroxyglutarate (L-2HG) that regulates key aspects of cell identity and function. The proposed research will test the importance of L-2HG in normal blood stem cells and leukemia cells to determine how L-2HG affects cells and whether targeting the L-2HG pathway represents a useful and broadly applicable strategy for treating cancer.

PI_NAMEs: INTLEKOFER, ANDREW MICHAEL (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Affect;alpha ketoglutarate;Biochemical;Biological;Biology;Blood;Blood Cells;Bone Marrow;cancer cell;cancer stem cell;cancer therapy;Cell Differentiation process;Cell Lineage;Cells;Cellular Metabolic Process;Chemicals;chiral molecule;Chromatin;chromatin modification;Chromatin Remodeling Factor;Chromatin Structure;Couples;Cues;Data;differentiation in vitro;enantiomer;Enzymes;Equilibrium;Experimental Models;Gene Expression;Genes;Genetic;genetic manipulation;Genetically Engineered Mouse;Growth;Hematopoiesis;Hematopoietic;hematopoietic differentiation;Hematopoietic stem cells;Hematopoietic System;Human;Hypoxia;Hypoxia Inducible Factor;In Vitro;in vivo;inhibitor;insight;Isocitrate Dehydrogenase;Lactate Dehydrogenase;leukemia;leukemia treatment;Leukemic Cell;leukemic stem cell;leukemic transformation;leukemogenesis;Maintenance;Malignant - descriptor;Malignant Neoplasms;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;Molecular;Molecular Abnormality;mutant;Mutation;Nature;new therapeutic target;Normal Cell;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Oxygen;Pathogenesis;Pathway interactions;patient derived xenograft model;patient subsets;Patients;Pharmaceutical Preparations;pharmacologic;Production;Reaction;Research;response;Role;self-renewal;Signal Transduction;small molecule inhibitor;Somatic Mutation;Source;Specimen;stem;stem cell biology;stem cell differentiation;stem cell population;stem cells;stemness;Stereoisomer;System;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;tool;Xenograft procedure

PROJECT_TITLE: Metabolic control of normal and malignant hematopoiesis

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Services;Physical Rehabilitation;Rehabilitation

PI_NAMEs: STEVANS, JOEL M (contact)

PROJECT_TERMS: Academic Training;Acceleration;Address;Anecdotes;Area;Clinical;Communities;Competence;Comprehension;Development;Discipline;Evaluation;evidence base;experience;Exposure to;falls;Future;Goals;Health system;implementation science;improved;Informatics;innovation;Knowledge;Leadership;Learning;learning ability;Link;Methods;multidisciplinary;Population;Rehabilitation Outcome;rehabilitation research;Rehabilitation therapy;rehabilitative care;Research;Research Ethics;Research Methodology;Research Personnel;Research Technics;Research Training;Resource Development;Resources;routine practice;Science;skills;Surveys;System;systems research;technique development;Techniques;Training;Translating;Work;World Health

PROJECT_TITLE: LEARRN: Didactic Interactions Component


PROJECT_TERMS: Address;Adopted;Applications Grants;Area;Award;career;Caring;Collaborations;Country;Data;design;Development;Ensure;experience;Funding;Future;graduate student;Grant Review Process;Health;health plan;Health Services;Health system;Home;human subject protection;improved;Incubated;innovation;Institution;Knowledge;Lead;Learning;Letters;Measures;Mediating;member;Mentors;Nursing Faculty;Outcome;Patient-Focused Outcomes;Peer Review;Physical therapy;Pilot Projects;Positioning Attribute;preference;Process;programs;Progress Reports;Provider;Publications;Records;rehabilitation research;Rehabilitation therapy;Research;Research Personnel;Research Project Grants;Research Proposals;Safety;Seasons;Senior Scientist;skills;Stream;success;System;Talents;Targeted Research;Technical Expertise;Testing;Therapeutic Studies;Time;Translations;United States National Institutes of Health;Work

PROJECT_TITLE: LEARRN: Pilot Studies Component


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH The genetic basis for normal mammalian aging and age-related disease is still largely unexplored. Continued multidisciplinary, rigorous and creative training of the next generation of scientists is necessary for the biomedical and scientific community to develop therapies and interventions for the growing aging population and the increase in Alzheimer's disease incidence.

PI_NAMEs: HOWELL, GARETH R;KORSTANJE, RONNY  (contact)

PROJECT_TERMS: Aging;Alzheimer's disease related dementia;precision genetics;Training Programs

PROJECT_TITLE: Training Program in Precision Genetics of Aging, Alzheimer's Disease and Related Dementias


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Disability Research;Health Services;Physical Rehabilitation;Rehabilitation

PI_NAMEs: SLAVIN, MARY D (contact)

PROJECT_TERMS: Adoption;Advertising;Archives;Arthritis;Boston;care delivery;college;Communication;Communities;Competence;Databases;design;Development;Disabled Persons;dissemination strategy;Electronic Mail;Electronics;Ensure;Evaluation;faculty mentor;Funding;Health system;interest;International;Lead;Learning;Manuscripts;Marketing;Media Campaign;member;news;Newsletter;online resource;outreach;Pamphlets;Persons;Press Releases;Production;programs;recruit;rehabilitation research;Rehabilitation therapy;rehabilitative care;Reporting;Research;Research Activity;Resources;Running;Scholars Program;Services;social media;Students;symposium;Techniques;Training;training opportunity;underserved area;Universities;web site;webinar;Work

PROJECT_TITLE: LEARRN: Promotion of Center Expertise Component


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Services;Physical Rehabilitation;Rehabilitation

PROJECT_TERMS: Achievement;Arthritis;Back;Boston;Budgets;Businesses;Caring;Chronic Disease;Collaborations;Committee Members;Communication;Communities;Complex;Dedications;Department of Defense;Doctor of Philosophy;Effectiveness;Evaluation;Evaluation Research;Expenditure;experience;Feedback;Fellowship Program;Fostering;Foundations;Funding;Gerontology;Goals;Health Care Research;Health Personnel;Health Services;Health Services Research;Health system;Healthcare Systems;improved;Infrastructure;innovation;Institution;Intervention Studies;Leadership;Learning;Long-Term Care;Measurement;member;Mission;Modeling;older adult;Outcome;Physical therapy;Principal Investigator;process improvement;Program Evaluation;programs;Public Health Schools;Quality of Care;Rehabilitation Outcome;rehabilitation research;Rehabilitation therapy;rehabilitative care;Reporting;Research;Research Personnel;Resource Allocation;Resource Sharing;Resources;Site;Social Work;sound;technique development;Testing;Therapeutic Studies;Training;United States Department of Veterans Affairs;Universities;Work

PROJECT_TITLE: LEARRN: Techniques Development Component


PROJECT_TERMS: Address;American;Award;Boston;Clinic;clinical care;Collaborations;Communication;Complex;Department of Defense;Ensure;experience;Faculty;Foundations;Funding;Goals;Health Services Research;Health system;Healthcare;Home Care Services;improved;Infrastructure;innovation;Institution;Leadership;Learning;Medical center;meetings;member;Mentors;Mission;Modeling;Physical therapy;Pilot Projects;Process;Rehabilitation Outcome;rehabilitation research;Rehabilitation therapy;rehabilitative care;Research;Research Personnel;Resources;Site;Structure;Sum;Techniques;Therapeutic Studies;Training;Translating;Trust;Universities;Work

PROJECT_TITLE: LEARRN:  Collaboration Between Other Institutions Component


NIH_SPENDING_CATS: Cancer;Genetics

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Project Narrative: The majority of approved molecularly targeted cancer drugs are either kinase inhibitors or monoclonal antibodies that target cancer-specific molecules. Several lines of evidence have demonstrated that oncogenic transcription factors are both necessary and sufficient to drive cancer initiation and progression. Although targeting transcription factors has proven difficult to date, we propose to build on work that has identified initial inhibitors of a key epigenetic mechanism, histone acetylation, that regulates gene expression. Using a novel high throughput small molecule screen, fit for purpose biochemical and cellular assays, medicinal chemistry and systematic genetics, we propose to identify histone acetyl transferase inhibitors suitable for clinical development and the means to stratify patients most likely to respond to these inhibitors.

PI_NAMEs: HAHN, WILLIAM C. (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Androgens;Animal Model;Antineoplastic Agents;Binding;Biochemical;Biological Assay;Biophysics;Cancer Biology;cancer cell;Cancer cell line;cancer initiation;Cancer Patient;cancer subtypes;cancer therapy;candidate validation;Caring;Cell Line;Cell Lineage;cell type;Cells;Cellular Assay;Chemicals;Chemosensitization;Chromatin;Clinical;clinical development;Complex;cost effective;CREBBP gene;Credentialing;CRISPR/Cas technology;Development;Dose;drug development;Drug Kinetics;E1A-associated p300 protein;EP300 gene;Epigenetic Process;Estrogens;experience;Experimental Genetics;fitness;Fluorescence Polarization;follow-up;Gene Expression;Genes;Genetic;Genetic Transcription;Genomics;Goals;Histone Acetylation;histone acetyltransferase;histone-binding proteins;Histones;Human;improved;in vivo;inhibitor;insight;Interdisciplinary Study;kinase inhibitor;Knock-out;lead candidate;lead series;Libraries;Maintenance;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;member;meter;Modeling;Molecular Target;Monoclonal Antibodies;Mutate;Mutation;novel;Oncogenes;Oncogenic;patient population;patient stratification;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;pre-clinical;Predisposition;Property;Prostate;Protein Inhibition;Recombinants;Recurrence;Reporting;response;Retinoic Acid Receptor;scaffold;Series;Signal Pathway;small molecule;small molecule inhibitor;Specificity;structural biology;Structure;success;Technology;Therapeutic;therapeutic target;TMPRSS2 gene;tool;transcription factor;Transcription Factor Oncogene;Transferase;tumor growth;tumor initiation;tumor progression;Tumor Subtype;Work

PROJECT_TITLE: Development of p300/CBP histone acetyltransferase inhibitors for oncogene-driven cancers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-F(55)R]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE This application requests support from NIH for the Southern California Clinical and Translational Science Institute (SC CTSI), a multi-disciplinary institute housed at the University of Southern California and Children's Hospital Los Angeles. In partnership with the Los Angeles County Department of Health Services and broad based community health organizations in Los Angeles, the SC CTSI seeks to develop and support multidisciplinary clinical and translational research that will improve the health and address challenges in the conduct of clinical research, with particular focus on diverse, high disparity communities. Project Narrative Page 208

PI_NAMEs: BUCHANAN, THOMAS A (contact);KIPKE, MICHELE D.

PROGRAM_OFFICER_NAME: BROWN, PATRICK

PROJECT_TERMS: Address;Adopted;African American;Area;Artificial Intelligence;Asian Americans;Attitude;California;care outcomes;career;Clinical;Clinical and Translational Science Awards;clinical care;Clinical Research;Clinical Sciences;Collaborations;Colorado;Communities;community engaged research;community engagement;Community Health;Community Health Aides;community research;Complement;Complex;County;Data;data hub;data infrastructure;design;Development;Development Plans;Discipline;Disease;Disparity;Disparity population;Ecosystem;Electronics;Environment;experience;Fostering;Funding;Goals;Growth;Health;health care delivery;health data;health determinants;health organization;Health Services;Health system;Healthcare;Improve Access;improved;Individual;Informatics;innovation;insight;Institution;Instruction;Knowledge;Latino;Leadership;life span;Los Angeles;Machine Learning;member;Mentors;Methods;Mission;Modeling;multidisciplinary;Natural Language Processing;novel strategies;Outcome;Pathway Analysis;Patients;Pediatric Hospitals;peer;Peer Review;personalized approach;Population;Population Heterogeneity;Population Research;Process;process improvement;Productivity;Program Sustainability;programs;Reproducibility;Request for Applications;Research;research and development;Research Institute;Research Personnel;Research Priority;Research Training;Resources;Role;Science;Services;Site;skills;social;Social Network;Social Sciences;sound;Special Population;success;systems research;Talents;Television;Time;tool;Training;Training and Education;Translating;Translational Research;Translations;underserved community;United States National Institutes of Health;Universities;Vision;Work;Workforce Development


ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Public Health Relevance We propose the development and implementation of an ultra-long acting drug delivery implant for HIV prevention, offering constant, extended drug release, reliable user-independent dosing, discretion and safety for long-term use. The proposed research will increase understanding of the pharmacology of long-acting implantable drug delivery devices and establish the clinical merit of our implant in terms of prevention efficacy and safety of islatravir across different routes of HIV transmission, namely rectal, penile, vaginal, and intravenous. The goal is to maintain effective preventive drug levels systemically for an unprecedented duration of 2 years, advancing the device towards clinical development as a viable, widely acceptable HIV prevention strategy.

PI_NAMEs: GRATTONI, ALESSANDRO  (contact)

PROGRAM_OFFICER_NAME: PORTER, KRISTEN AMY

PROJECT_TERMS: Address;Adherence;AIDS prevention;Anti-Retroviral Agents;biomaterial compatibility;Clinical;clinical development;Clinical Research;clinical translation;clinically relevant;Complex;Cutaneous;Developing Countries;Development;Devices;Diffusion;Dose;drug action;Drug Controls;Drug Delivery Systems;Drug Implants;Drug Kinetics;effectiveness evaluation;Equipment;Excision;experience;Fatigue;Formulation;global health;Goals;high risk;HIV;HIV anti-retroviral;HIV Infections;Human;Implant;Implantable Infusion Pumps;implantation;improved;In Vitro;Individual;individual variation;Injectable;innovation;Intravenous;Ion Channel;Kinetics;Legal patent;Logistics;Lymphocyte Depletion;Manuals;Medical;Membrane;minimally invasive;Modeling;multidisciplinary;nanochannel;nanofluidic;Nickel;nonhuman primate;Operative Surgical Procedures;Oral;penis;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Pharmacology;Physiological;pill;Polymers;pre-clinical;pre-exposure prophylaxis;preference;prevent;Prevention;Prevention strategy;Preventive;prophylactic;public health relevance;Pump;Rattus;Recording of previous events;Rectum;Regimen;Research;response;Route;Safety;Scanning Electron Microscopy;side effect;Silicon;silicon carbide;simian human immunodeficiency virus;Solid;subcutaneous;Syringes;System;Technology;Testing;Therapeutic;Tissues;transmission process;treatment duration;tripolyphosphate;Vagina;viral transmission;Virus Diseases

PROJECT_TITLE: Ultra-long Acting Transcutaneously Refillable Islatravir Nanofluidic Implant for HIV Pre-Exposure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-T(90)]


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE This is a proposal for the competitive renewal of a T32 supported Training Program in Developmental and Stem Cell Biology at the Weill Cornell Graduate School of Medical Sciences. The existing, inter- disciplinary research programs in Developmental Biology, Stem Cell Biology and Systems Biology at the Graduate School are outstanding, highly interactive, and have outstanding faculty and pre- and post-doctoral trainees. To support the next generation of academic leaders in biomedical and translational sciences, it is imperative to provide the highest level of organized instruction through a T32-supported training program in developmental and stem cell biology, tissue differentiation, organogenesis, systems biology, and regenerative medicine.

PI_NAMEs: BAO, ZHIRONG ;STUHLMANN, HEIDI  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Development;stem cell biology;Training Programs


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Services

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: The purpose of this training grant to is provide intensive short-term training in research areas of interest to NIA for 10 selected pre-doctoral medical students in the most outstanding laboratories and training sites in the Yale School of Medicine relating to aging. The specific training experiences will range from fundamental molecular biology, cellular and organ physiology to applied clinical research. The program is designed to attract the most highly qualified Yale medical students into careers as physician-scientists in the biomedical sciences in areas of interest to NIA.

PI_NAMEs: CHAUDHRY, SARWAT I (contact);HERZOG, ERICA L;TINETTI, MARY E

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Address;Aging;Anesthesia procedures;Applications Grants;Area;Award;Behavioral Sciences;Blood Vessels;Cardiovascular system;career;Clinical;Communicable Diseases;community engaged research;comparative;design;Discipline;Educational Curriculum;Emergency Medicine;Endocrinology;Ensure;Environment;experience;experimental study;Funding;Geriatrics;Goals;Health Policy;Health Professional;Health Services;Home;Institution;interest;Internal Medicine;Laboratories;Laboratory Research;Lung;medical schools;Medical Students;Medicine;Mentors;Mentorship;Neurology;Neurosciences;Operative Surgical Procedures;Orthopedics;Outcome;Physicians;pre-doctoral;programs;Psychiatry;Public Health;Qualifying;Rehabilitation therapy;Research;Research Personnel;Research Support;Research Training;Rheumatology;Schools;Science;Scientist;Site;Social Sciences;student training;Students;Training;Training Programs;Training Support;translational pipeline;Writing

PROJECT_TITLE: NIA Short Term Research Training: Students in Health Professional Schools


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The rapid emergence and spread of Clostridioides (Clostridium) difficile in hospitals and nursing homes presents a large and urgent threat to human health. We are studying how C. difficile assembles and remodels its cell envelope during growth and division. These studies are relevant to public health because they might lead to new ways to combat C. difficile infections.

PI_NAMEs: ELLERMEIER, CRAIG D (contact);WEISS, DAVID S

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Address;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Attention;Bacteria;beta-Lactams;Biochemistry;Biogenesis;Biology;Carboxypeptidase;Categories;cell assembly;Cell division;cell envelope;Cell Wall;Cellular biology;Cellular Morphology;Cessation of life;Clostridium;Clostridium difficile;Colon;combat;Complex;CRISPR interference;crosslink;Enzymes;Essential Genes;experimental study;Fluorescence Microscopy;Gene Deletion;Gene Expression;Gene Silencing;Genes;Genetic;Genetic Transcription;Genome;Germination;Glucosamine;glycosyltransferase;Goals;Growth;gut bacteria;gut colonization;Health;Homeostasis;Hospitals;Human;In Situ;Individual;Infection;insight;Investigation;Knowledge;Label;Libraries;Maps;Masks;microbiota;Microscopy;model organism;Modeling;Morphology;new therapeutic target;novel;novel strategies;Nursing Homes;Organism;pathogen;Pathway interactions;Penicillin-Binding Proteins;Peptides;Peptidoglycan;Peptidyltransferase;Persons;PPBP gene;Predisposition;prevent;Process;Proteins;Public Health;Regulation;Reproduction spores;Role;Site;System;Testing;tool;United States;Vancomycin;Visualization

PROJECT_TITLE: Cell Envelope Biogenesis in Clostridioides difficile

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Services;Kidney Disease;Networking and Information Technology R&D (NITRD);Organ Transplantation;Primary Health Care;Telehealth;Transplantation

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Living kidney donation is the best available therapy for kidney failure patients. However, the medical evaluation process of potential living donors is challenging and lengthy, and access to transplant centers is a key barrier to engagement of potential donors. The goal of this project is to integrate a telemedicine care coordination intervention in the donor evaluation process to enhance engagement of potential donors to complete their evaluation and counseling more effectively and efficiently.

PI_NAMEs: AL AMMARY, FAWAZ  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Adoption;Ambulatory Care Facilities;Award;care coordination;Caring;Client satisfaction;Clinic Visits;Clinical Trials Design;Collection;Complex;Consensus;Counseling;Data;design;digital intervention;effectiveness testing;Eligibility Determination;Enrollment;Ensure;Ethnic Origin;Evaluation;experience;Expert Opinion;Feedback;Focus Groups;Funding;Future;Geography;Goals;Image;Improve Access;improved;innovation;Intervention;Intervention Trial;Interview;Kidney;Kidney Failure;Kidney Transplantation;Knowledge;Laboratories;Living Donors;living kidney donor;Logistics;Medical;Medical History;Methods;multidisciplinary;Nephrectomy;Outcome;pandemic disease;Participant;Patients;Perception;Persons;Phase;pilot test;preference;Primary Care;Process;process improvement;programs;Protocols documentation;Published Comment;Qualitative Research;Questionnaires;Race;randomized, clinical trials;Reporting;Research;Research Methodology;Sampling;satisfaction;screening;Screening Result;skills;social;Structure;Surveys;Telemedicine;Time;Translating;transplant centers;video visit;Visit;Work

PROJECT_TITLE: Telemedicine for Evaluation and Counseling of Living Kidney Donor Candidates