NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Lung;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE/ PUBLIC HEALTH RELEVANCE Sudden unexpected death in epilepsy (SUDEP) is a leading cause of premature death in people with chronic uncontrolled epilepsy, and targeted prevention strategies currently do not exist. Studies of patients with epilepsy who died while being monitored in hospital epilepsy units reveal that most SUDEP is due to post-convulsive breathing arrest. Our project identifies neuromodulation approaches for breathing rescue that will aid in the design of preventive SUDEP interventions.

PI_NAMEs: LACUEY LECUMBERRI, NURIA  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acceleration;Address;Affect;Age;Air Movements;Amygdaloid structure;Anatomy;Anterior;Apnea;Beds;Brain;Breathing;Carbon Dioxide;Cardiovascular system;Cell Nucleus;Central Sleep Apnea;Cessation of life;Chronic;cingulate cortex;Clinical Trials;cohort;Complication;connectome;Coupled;Data;design;efficacy clinical trial;Electric Stimulation;Electrocardiogram;Electrodes;Electroencephalography;Epilepsy;Europe;Evaluation;Failure;Frequencies;Goals;Graph;Heart Arrest;Heart failure;high risk;Hippocampus;Hospitals;Implant;Individual;innovation;insight;Insula of Reil;Intervention;Intractable Epilepsy;Knowledge;Life Expectancy;Medial;Medical;millisecond;Monitor;Motor;Motor Seizures;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;neuroregulation;Nose;Operative Surgical Procedures;Oral;Oxygen;patient population;Patients;Persons;Physiologic pulse;Plethysmography;Population;premature;prevent;preventable epilepsy;Prevention strategy;Preventive;Prone Position;Prosencephalon;public health relevance;Refractory;Research;Respiration;respiratory;Respiratory Failure;response;restoration;Risk;Risk Factors;Seizures;Sensory;sex;Signal Transduction;Site;Stimulus;Stroke;Structure;study population;sudden unexpected death in epilepsy;System;Testing;Thalamic structure;Tidal Volume;Time;Training;translational impact;ventilation;Vulnerable Populations;Width;Work

PROJECT_TITLE: Breathing Rescue for SUDEP Prevention (BreatheS)

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE While it has been thought that individuals with severe spinal cord injuries will not recover the ability to functionally move their lower extremities, spinal cord stimulation has emerged as a promising intervention challenging this long-held assumption. While spinal cord stimulation allows for restored voluntary movement after spinal cord injury, there is a lack of mechanistic understanding regarding how it works and why some individuals respond better than others. Thus, the overall objective of this proposal is to apply neuroimaging biomarkers to generate fundamental knowledge regarding responsiveness to spinal cord stimulation.

PI_NAMEs: SMITH, ANDREW CRAIG (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Address;Axon;Bilateral;Biological Markers;biomarker identification;Case Study;Classification;clinical examination;Clinical Management;cohort;cost;design;electric field;Electromyography;Event;Foundations;Funding;Generations;Goals;Handedness;Health;Human;Implant;implantation;improved;improved outcome;Individual;Individuals with physical disabilities;Injury;Institution;Intervention;Investigation;Ipsilateral;Knowledge;Leg;Life Expectancy;Light;Lower Extremity;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;man;Manuscripts;Measures;Motor;Movement;Muscle;National Institute of Child Health and Human Development;neural network;neuroimaging;neuroimaging marker;Neuronal Plasticity;neuroregulation;Neurostimulation procedures of spinal cord tissue;Operative Surgical Procedures;Participant;Pattern;personalized approach;Persons;Physical Function;Pilot Projects;Productivity;Prognosis;prospective;Quality of life;Recovery;rehabilitation research;Reporting;Research;Research Personnel;Residual state;Resolution;Sensory;Side;Signal Transduction;sound;Spinal Cord;Spinal cord damage;Spinal cord injury;Supine Position;theories;Time;Tissues;tool;Touch sensation;Training;Travel;treatment strategy;trend;United States National Institutes of Health;Walking;Work

PROJECT_TITLE: Improving mechanistic understanding of responsiveness to spinal cord stimulation after spinal cord injury

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: WOODS HOLE

ORG_NAME: MARINE BIOLOGICAL LABORATORY

ORG_STATE: MA

PHR: PROJECT NARRATIVE The incidence of human fungal infections has dramatically increased in recent years. The objective of our Molecular Mycology course at the Marine Biological Laboratory is to provide foundational knowledge and training in the techniques, procedures, and concepts in molecular mycology through direct experiences working with fungi and animal models of fungal disease. Importantly, MOMY provides critical career mentoring and professional development opportunities throughout the course to all participants.

PI_NAMEs: ANDES, DAVID R;CRAMER, ROBERT ANDREW;HYMAN, LINDA E (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Achievement;Address;Affect;Animal Model;Anniversary;anti-fungal agents;Authorship;Biological;Biology;Biomedical Research;career;Clinical;Collaborations;Communities;Data;data sharing;Development;Development Plans;Disease;drug development;Education;Ethics;experience;experimental study;Faculty;faculty mentor;Funding;Fungi Model;fungus;Future;Grant;hands-on learning;Health;Human;Humanities;Immune;Immune response;Immunology;immunoregulation;Incidence;Instruction;Knowledge;Laboratories;marine;Medical;meetings;Mentors;Methods;microbiome components;Microscopy;Mission;Molecular;Molecular Biology;Morbidity - disease rate;mortality;Mycoses;National Institute of Allergy and Infectious Disease;novel;Nursing Faculty;Paper;Participant;pathogen;Pathogenesis;patient population;peer;Personal Satisfaction;Pharmaceutical Preparations;Physicians;Positioning Attribute;Procedures;programs;Publishing;Recommendation;Recording of previous events;Research;research faculty;Research Personnel;response;responsible research conduct;Role;Science;Scientist;skill acquisition;skills;skills training;Students;Surveys;Techniques;Technology;tenure track;The science of Mycology;Therapeutic;Training;Underrepresented Minority;United States National Institutes of Health;Writing

PROJECT_TITLE: Molecular Mycology: Current Approaches to Fungal Pathogenesis (MoMy) Training Course


ADMINISTERING_IC: DK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Kidney Disease;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE  Acute kidney injury (AKI) is a common and often devastating complication following cardiac surgery, in critical illness, and in other clinical settings, and no pharmacologic therapy reliably prevents or treats AKI. Abundant data suggest that iron excess plays a key role in AKI, particularly in the setting of cardiac surgery. We propose a 3-center, double-blind, randomized controlled trial (n=300) to test whether administration of the iron chelator, deferoxamine, prevents AKI following cardiac surgery in adult patients at high risk of AKI.

PI_NAMEs: LEAF, DAVID EVAN (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Academic Medical Centers;Acute;Acute Renal Failure with Renal Papillary Necrosis;Adult;Affinity;Animal Model;Animals;Atrial Fibrillation;Attenuated;Binding;Blood;Boston;Cardiac;Cardiac Surgery procedures;Cardiac Volume;Cardiopulmonary Bypass;CD14 gene;Cell surface;Cessation of life;Chronic;Chronic Kidney Failure;Circulation;Clinical;Complex;Complication;Conduct Clinical Trials;Controlled Environment;Creatinine;Critical Illness;cytokine;Data;Deferoxamine;Delirium;Development;Double-Blind Method;Enrollment;Excretory function;experience;Exposure to;Feces;Ferritin;Flow Cytometry;Functional disorder;Heme;Hemoglobin;Hemolysis;high risk;Hospitals;Hour;Human;Hypotension;improved;Incidence;Inflammation;Inflammatory;inflammatory marker;Infrastructure;Infusion procedures;Injury;injury prevention;Injury to Kidney;innovation;insight;Interleukin-6;Intravenous infusion procedures;Investigation;Iron;Iron Chelating Agents;Iron Chelation;iron metabolism;Iron Overload;Isoprostanes;Kidney;LCN2 gene;Left Ventricular Ejection Fraction;Measures;Mechanical ventilation;Mediating;monocyte;mortality risk;Myocardial Infarction;myocardial injury;nephrotoxicity;new therapeutic target;next generation;Normal saline;novel;Operative Surgical Procedures;Organ;organ injury;Outcome;Output;oxidative damage;Oxidative Stress;participant enrollment;Pathogenesis;Patients;peripheral blood;Peroxidases;pharmacologic;Phase;Phenotype;Physiological;Placebos;Plasma;Play;Postoperative Period;Pre-Clinical Model;precision medicine;prevent;Prevention;primary endpoint;Production;prophylactic;Prospective, cohort study;Public Health;Randomized;Randomized, Controlled Trials;Renal Replacement Therapy;research study;Risk;Role;secondary endpoint;Sepsis;Serum;Severities;Surgeon;Testing;Therapeutic;TNF gene;Transcript;transcriptome;transcriptome sequencing;Transferrin;translational study;Tubular formation;urinary;Urine

PROJECT_TITLE: Deferoxamine for the Prevention of Acute Kidney Injury

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE A fundamental goal in neuroscience is to understand how neural circuits process sensory information to allow for adaptive behavioral responses; this project investigates how neural circuits in the mammalian olfactory system transform olfactory sensory inputs and how this transformation is shaped by the sampling behavior of the animal. Because the sense of smell presents unique problems to the nervous system in terms of stimulus detection and recognition of complex stimuli, understanding how the brain solves these problems will likely lead to general insights into how the brain processes information. These insights could be important in developing improved prosthetic sensory organs and improving therapeutic approaches to sensory system deficits.

PI_NAMEs: WACHOWIAK, DALE M (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Afferent Neurons;Animal Behavior;Animals;Automobile Driving;awake;Behavior;behavioral response;Brain;Calcium;Cells;Chemistry;Code;Color;Complex;Dependence;design;Detection;Environment;Esthesia;experimental study;Frequencies;Generations;Glutamates;Goals;Head;Image;improved;in vivo;information processing;Inhalation;innovation;insight;Link;Modeling;Monitor;Mus;Nature;Nervous System;neural;neural circuit;Neurons;Neurosciences;Odors;olfactory bulb;Olfactory Pathways;olfactory stimulus;Optical reporter;optogenetics;Organ;Output;Pathway interactions;Pattern;pharmacologic;Play;postsynaptic;predictive modeling;presynaptic;Process;Property;response;Role;Sampling;sensor;Sensory;sensory input;Sensory Process;sensory prosthesis;sensory system;Shapes;Signal Transduction;Smell Perception;Stimulus;Synapses;temporal measurement;Testing;Therapeutic;Time;Work

PROJECT_TITLE: Dynamics of odor coding and processing by neural circuits in the olfactory bulb

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative: Type 2 diabetes mellitus (T2D) is a significant public health problem affecting ~30 million people. Obesity, insulin deficiency and hyperglycemia all precede the diagnosis of T2D and are long known to promote inflammation and ultimately lead to microvascular complications in adults. More recently, research has identified brain-related complications in adult-onset T2D, including reduced regional brain structure and function, impaired cognition, and increased lifetime risk for Alzheimer’s disease. Alarmingly, an increasing number of children and adolescents are being diagnosed with T2D, likely due to the growing prevalence and earlier onset of obesity. Youth-onset T2D appears to have a more aggressive course than adult-onset T2D, with early onset and rapid increase in complications. In addition, a few small studies of youth-onset T2D have reported robust differences in regional brain structure and cognition, suggesting that brain effects may follow the same aggressive course as the more typical complications. Unfortunately, little is known about the risk factors associated with alterations in brain structure and function in youth with T2D. To address this critical gap in knowledge, we propose to study youth across the spectrum of obesity and metabolic dysfunction. This approach will allow us to disentangle the relationship of key features of T2D risk (e.g. obesity, insulin resistance, insulin deficiency and dysglycemia) to intermediate changes that pose a risk for the brain (e.g. inflammation) and reduced brain structure and function associated with T2D in youth.

PI_NAMEs: ARSLANIAN, SILVA A;HERSHEY, TAMARA G (contact)

PROGRAM_OFFICER_NAME: WOO, THERESA TESLOVICH

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Age;Aggressive course;Alzheimer's disease risk;American;arterial spin labeling;Beta Cell;Blood Vessels;Body mass index;Body System;Brain;brain health;Brain region;Cell Physiology;Cerebrovascular Circulation;Child;Clinical;Cognition;Cognitive;cognitive testing;Delayed Memory;Developmental Process;Diagnosis;Diffusion;Disease;early onset;early-onset obesity;Ethnic Origin;executive function;follow-up;Functional disorder;Funding;glucose tolerance;Goals;Hippocampus;Hyperglycemia;Impaired cognition;impaired glucose tolerance;Impairment;Inflammation;Insulin deficiency;Insulin Resistance;insulin secretion;Intervention;Knowledge;lifetime risk;Magnetic Resonance Imaging;Measures;Metabolic;Metabolic dysfunction;Microvascular Dysfunction;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;neurodevelopment;neuroinflammation;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;Overweight;Persons;Physiological;Predictive Factor;Prevalence;processing speed;Puberty;Public Health;Race;Reporting;Research;Risk;Risk Factors;sex;Site;Socioeconomic Status;spectrograph;Statistical Models;Structure;systemic inflammatory response;Time;Weight;white matter;Youth

PROJECT_TITLE: Brain Health Across the Metabolic Continuum in Youth at Risk for T2D

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Precision Medicine

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE The approval of novel cancer therapies by healthcare agencies is contingent on endpoints that aim to capture clinical benefit, determined in part by radiologic assessment of treatment response. However, currently used metrics may not always capture treatment success or failure. The insights from this study will lay the groundwork for integrating advanced imaging and plasma circulating tumor DNA (ctDNA)-based biomarkers in the future that may be used by regulatory agencies around the globe for the purpose of assessing and approving novel precision therapies and ultimately allow the possibility for personalized precision medicine.

PI_NAMEs: BERGER, MICHAEL F. (contact);DRILON, ALEXANDER ;GINSBERG, MICHELLE

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Area;Authorization documentation;Biological Assay;Biological Markers;cancer therapy;cancer type;Categories;cell free DNA;Clinical;Clinical Trials;co-clinical trial;Collection;Complement;cone-beam computed tomography;cytotoxic;Data;deep sequencing;Development;Disease;DNA sequencing;drug development;early phase clinical trial;Enrollment;experience;Failure;falls;Foundations;Frequencies;Future;Gene Frequency;genetic variant;Genome;genomic profiles;Goals;Guidelines;Healthcare;Image;imaging modality;imaging scientist;immunomodulatory therapies;immunoregulation;improved;improved outcome;individualized medicine;insight;liquid biopsy;Liquid substance;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;Memorial Sloan-Kettering Cancer Center;Methods;Monitor;Mutation;next generation sequencing;novel;novel therapeutics;Outcome;partial response;Patients;Pharmaceutical Preparations;Phase;Plasma;Plasma Cells;Positron-Emission Tomography;precision medicine;Precision therapeutics;Prediction of Response to Therapy;Progression-Free Survivals;Progressive Disease;prospective;Radiology Specialty;Research;response;Role;Sampling;Scientist;Services;Stable Disease;success;targeted treatment;Testing;Time;tool;treatment response;Treatment Side Effects;trend;tumor;Tumor Burden;tumor DNA;Tumor Tissue;X-Ray Computed Tomography

PROJECT_TITLE: Integration of Imaging and Circulating Plasma Cell-Free DNA Sequencing Using MSK-ACCESS to Monitor Treatment Response and Predict Progression in Patients With Multiple Cancers on Targeted Therapy

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The way an individual responds to cues associated with rewards may be a key determinant in vulnerability to addiction and relapse. We will utilize an animal model to identify critical components of the neural circuitry that that contribute to individual differences in cue-reward learning and relapse propensity. The findings from these studies will enhance our understanding of the pathophysiology of substance abuse and could lead to novel targets for the treatment of addiction and related disorders.

PI_NAMEs: FLAGEL, SHELLY BETH (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Abstinence;addiction;addiction liability;Affect;Animal Model;Attenuated;Behavior;Behavior Control;cocaine self-administration;Corpus striatum structure;Cues;designer receptors exclusively activated by designer drugs;Disease;Dopamine;Drug Addiction;drug seeking behavior;Drug user;Engineering;Environment;Equilibrium;experience;experimental study;Exposure to;Extinction;Food;Functional disorder;genetic approach;Goals;hypocretin;Hypothalamic structure;in vivo;incentive salience;Incentives;Individual;Individual Differences;individual variation;interest;Lateral;Learning;Lesion;maladaptive behavior;Mediating;Microdialysis;Molecular Genetics;motivated behavior;Motivation;motivational processes;neural;neural circuit;Neurobiology;neurochemistry;Neurons;novel;Nucleus Accumbens;Output;Pathway interactions;Pharmaceutical Preparations;Play;Predictive Value;Predisposition;Process;Property;psychologic;Psychopathology;Rattus;receptor;Relapse;Resources;response;Rewards;Role;selective expression;Signal Transduction;Stimulus;Structure of paraventricular nucleus of thalamus;Substance abuse problem;Testing;Thalamic structure;Variant;vector;Ventral Tegmental Area;Viral Vector;Work

PROJECT_TITLE: Probing the role of a hypothalamic-thalamic-striatal circuit in cue-driven behaviors

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Climate-Related Exposures and Conditions;Clinical Research;Lung;Pediatric;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Airway tree size varies in the general population and is associated with much higher risk of death from diseases linked to smoking and other noxious pollutants. This research grant renewal builds upon prior work to establish the early life-origins of airway tree size, investigate candidate mechanisms that link airway tree size to tobacco smoking-related susceptibility, and define resilient airway tree size using clinical outcomes. These aims represent key gaps in knowledge toward understanding and ultimately targeting mechanisms of resilient lung development and maintenance across the lifespan to prevent disease and improve health in the 21st century.

PI_NAMEs: HERBSTMAN, JULIE BETH;SMITH, BENJAMIN M. (contact)

PROGRAM_OFFICER_NAME: HU, TOM CHIH-CHUANG

PROJECT_TERMS: absorption;Address;Adolescence;Adolescent;Adult;Air Pollution;airway inflammation;Anatomy;Atherosclerosis;Attenuated;Basal Cell;Biogenesis;Biological Markers;Birth;Caliber;candidate identification;Carbon Black;Cardiac;Cause of Death;Cessation of life;Chronic Obstructive Pulmonary Disease;cigarette smoke;Clinical;cohort;Computer Simulation;Data;Deposition;Development;disability-adjusted life years;Disease;disorder risk;Dose;Epidemiology;epidemiology study;Ethnic Origin;Etiology;exhaust;Exposure to;follow-up;forging;Functional disorder;Funding;Gene Expression;Gene Expression Profile;General Population;Health;high risk;Homeostasis;improved;in vivo;Inflammation;Inhalation;injured airway;innovation;Knowledge;Life;life span;Link;Lower Respiratory Tract Infection;Lung;lung development;lung imaging;Macrophage;Magnetic Resonance;Magnetic Resonance Imaging;Maintenance;Malignant neoplasm of lung;Measures;modifiable risk;mortality;mortality risk;multi-ethnic;never smoker;non-smoker;Outcome;particle;Particulate;Phenotype;Physiological;pollutant;population health;postnatal;Predisposition;prenatal;prenatal exposure;prevent;prospective;Publishing;Radiation;Research;Research Project Grants;resilience;response;response to injury;Risk Factors;Smoking;stem cell genes;stem cells;Structure;Terminal Bronchiole;Testing;Textbooks;Tobacco;Tobacco smoke;tobacco smoke exposure;Tobacco smoking behavior;trait;Trees;Variant;Work;X-Ray Computed Tomography;young adult

PROJECT_TITLE: Airway trees in the Anthropocene: Defining resilient airway trees and identifying the candidate mechanisms and etiologic factors that increase susceptibility to tobacco smoke and air pollution

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Infertility;Maternal Health;Pediatric;Pregnancy;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Relevance to Public Health: Defect in trophoblast lineage development results in early pregnancy loss or leads to pregnancies that are associated with pre-term birth, intrauterine growth restriction and preeclampsia, which cause serious adverse effects on maternal and infant health. These are major public health concerns. Therefore, a better understanding of trophoblast cell lineage development and function is critical to gain insights into important features of pregnancy loss and pregnancy associated disorders.

PI_NAMEs: PAUL, SOUMEN  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Adult;Adverse effects;ASCL2 gene;blastocyst;Cell Lineage;Cells;Chorion;Conceptus;conditional knockout;Cone;cytotrophoblast;Defect;Development;Disease;early pregnancy loss;Ectoderm;Embryo;Ensure;Epigenetic Process;fetal;Fetal Growth Retardation;Functional disorder;GCM1 gene;gene conservation;Gene Expression;Genetic Transcription;Glycogen;histone demethylase;Histones;Human;Impairment;implantation;Infant Health;insight;KDM1A gene;Knockout Mice;Labyrinth;Maintenance;Maternal Health;Maternal-Fetal Exchange;Mediating;Molecular;mouse model;Mus;mutant mouse model;natural Blastocyst Implantation;Parietal;Pathogenesis;Pathologic;Pathway interactions;Placenta;Placentation;Population;postnatal;PRDM1 gene;Pre-Eclampsia;Pregnancy;Pregnancy loss;premature;Premature Birth;prevent;Process;progenitor;programs;Public Health;Reproduction;Research;Role;self-renewal;Specific qualifier value;Spiral Artery of the Endometrium;stem cell population;stem cell self renewal;stemness;Syncytiotrophoblast;TACSTD1 gene;Testing;trophoblast;trophoblast stem cell;Villous

PROJECT_TITLE: Histone Demethylases and Trophoblast Differentiationt


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences

ORG_CITY: COLLEGE PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: This project aims to study emotion and motivation in the human brain of typical participants with functional magnetic resonance imaging. We will study mechanisms of escaping from threat and approaching reward and how they interact. The project attempts to contribute to the understanding to processes that support many human behaviors, and may inform potential treatments of conditions such as anxiety disorders and substance abuse.

PI_NAMEs: PESSOA, LUIZ  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Address;Amygdaloid structure;Animals;Anterior;Anxiety Disorders;Area;Association Learning;aversive conditioning;Aversive Stimulus;Basic Science;Behavior;Behavioral;Brain;Brain region;Calcium;cingulate cortex;Clinical;Cognition;Coin;Collaborations;Communities;conditioning;Conflict (Psychology);Data;Data Analyses;Desire for food;Dimensions;Emotional;Emotions;examination questions;experience;experimental study;face perception;Functional Magnetic Resonance Imaging;gang;Grant;Graph;Hippocampus;Human;Image;Individual;Insula of Reil;Knowledge;Link;Literature;Location;Machine Learning;midbrain central gray substance;Motivation;Movement;Neurons;Participant;Peer Review;Perception;Positioning Attribute;Prefrontal Cortex;Procedures;Process;Publications;Publishing;Research;Research Personnel;reward processing;Rewards;Rodent;Role;Safety;Series;stem;Stimulus;Structure of terminal stria nuclei of preoptic region;Substance abuse problem;Techniques;technology research and development;Testing;Time;Ventral Striatum;virtual;Vision;Visual attention;Work

PROJECT_TITLE: Interaction of Emotional Perception and Visual Attention

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Organ development relies on small signaling molecules, such as metabolites and lipids, that regulate cell behavior. The primary goals of my research are to: 1) identify signaling molecules that regulate development, and 2) investigate how cells sense and process these signals to make decisions.

PI_NAMEs: DICKINSON, ALEXANDRA JAZZ (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Anabolism;Atlases;Biochemical;Biology;cell behavior;Cells;Chemicals;Chemistry;Citrates;Decision Making;Defect;Development;Developmental Biology;Disease;Genes;Genetic;Goals;insight;Investigation;Lipids;Maintenance;Maps;mass spectrometric imaging;Measurement;Measures;Metabolism;Natural regeneration;novel;organ growth;Organism;Pathway interactions;Pattern;Perception;Plant Roots;Process;Proliferating;Property;Proteins;Regulation;Reporter;Research;Resolution;Retina;Retinaldehyde;Role;Root Tip;Signal Pathway;Signal Transduction;Signaling Molecule;Slice;small molecule;stem cell biology;stem cell division;stem cells;stress resilience;System;Technology;Tissues;Visualization;Work

PROJECT_TITLE: Illuminating the chemical biology of stem cell decisions in plant roots

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: Southern California consists of 10 contiguous Counties and is home to 10.8 million Latinos (representing 45.2% of the population) who are disproportionally affected by multiple and co-occurring chronic diseases, namely obesity, type 2 diabetes, nonalcoholic fatty liver disease, and dyslipidemia. This disparity begins to develop early in life, occurs within families, is magnified by inter-generational transmission, and is driven by multi-level factors including diet, cultural values, social determinants, economic factors, and environmental-level factors like access to healthy foods and other chemical exposures such as air pollution. Our overall goal is to understand how the complex inter-play between these multi-level factors contribute to multiple chronic disease disparities in Latinos across the life course, and to develop and evaluate the acceptance, delivery, and clinical efficacy of family- based, culturally sensitive solutions by establishing the Southern California Center for Chronic Health Disparities in Latino Families and Children (SCC-CHDLFC).

PI_NAMEs: GORAN, MICHAEL ISAAC (contact)

PROGRAM_OFFICER_NAME: HUELSNITZ, CHLOE OLIVIA

PROJECT_TERMS: Acceleration;Address;Affect;Age;Air Pollution;Biometry;Birth;California;Cardiometabolic Disease;career;Chemical Exposure;Child;Chronic;Chronic Disease;Clinical;clinical efficacy;cohort;Collaborations;Communication;Communities;community engagement;Complex;cost;County;cultural values;Data;Data Analyses;data harmonization;data management;data sharing;design;Development;Diet;disease disparity;disorder risk;Disparity;Dyslipidemias;early-life nutrition;Eating Behavior;Economic Factors;Education;efficacy evaluation;Elderly;Ensure;Environment;environmental intervention;Evaluation;Factor Analysis;Family;Foundations;Funding;Generations;Goals;Government;Health;Health Disparities Research;health disparity;Health Food;Home;Household;Individual;innovation;intergenerational;Intervention;Language;Latino;Latino Population;Lead;Leadership;Life;Life Cycle Stages;literacy;Los Angeles;Mentors;Methods;multidisciplinary;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Obesity;obesity treatment;Outcome;Parents;Pediatric Hospitals;Physical activity;Pilot Projects;Policies;Population;Prevalence;Prevention;Process;programs;randomized, clinical trials;Research;Research Personnel;Resources;response;Risk Reduction;Science;social;social determinants;social factors;success;Support System;synergism;Technical Expertise;telehealth;Testing;transmission process;treatment program;Underrepresented Populations;Universities;voucher

PROJECT_TITLE: Southern California Center for Chronic Health Disparities in Latino Children and Families.


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: 5 year old;Acceleration;Achievement;Address;Advisory Committees;Advocacy;Affect;Behavior Therapy;Behavioral;Benchmarking;Biological;Biometry;Birth;California;career development;Child;Chronic;Chronic Disease;Clinical;Clinical Informatics;Cohort Studies;Collaborations;Colorado;Communities;community engagement;Complex;Data;data harmonization;data management;data quality;Development;Dietary intake;disorder risk;Disparity;Dyslipidemias;effectiveness evaluation;Elderly;Ensure;environmental intervention;Environmental Risk Factor;Evaluation;Family;Feedback;Fostering;Generations;Goals;Government;health disparity;Household;improved;Individual;Institution;Intervention;Knowledge;Latino;Latino Population;Leadership;Life;Los Angeles;Measures;meetings;Mentors;Methodology;Methods;minority health;minority health disparity;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Nutritional;Obesity;obesity treatment;outreach;Parents;Pediatric Hospitals;Phenotype;Pilot Projects;Policies;Prevention;Prevention strategy;Program Evaluation;programs;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;response;Risk Reduction;Science;social factors;social health determinants;Specialized Center;Structure;success;synergism;System;Testing;Training;Translational Research;treatment effect;treatment program;Underrepresented Populations;Universities;Vision;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Breast Cancer;Cancer;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: DAVIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The proposed studies are aimed at understanding inter-organelle communication between lysosomes and mitochondria in mammalian cells, and how this communication contributes to cell viability and disease state. The successful completion of the studies could shed light on the cellular and molecular mechanisms underlying some of the genetic lysosomal storage diseases, and could provide an avenue for the development of novel anti-cancer drugs.

PI_NAMEs: CARRAWAY, KERMIT L (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Amiloride;amphiphilicity;Apoptosis;Apoptotic;Autophagocytosis;Biochemical;Biological;bis(monoacylglyceryl)phosphate;blood pressure control;Breast Cancer Cell;cancer cell;cancer recurrence;cancer stem cell;Caspase;Cathepsins;Cell Cycle;Cell Death;Cell Death Induction;Cell Death Process;Cell Differentiation process;Cell membrane;Cell Membrane Permeability;Cell model;Cell Survival;cell transformation;cell type;Cells;Ceramides;Cessation of life;Clinical;Communication;Cytosol;cytotoxic;cytotoxicity;Development;Disease;Disease Management;Diuretics;DNA Sequence Alteration;Drug Modelings;Drug resistance;Enzymes;ERBB2 gene;Event;Failure;Future;Genes;Genetic;Goals;improved;Induction of Apoptosis;insight;knock-down;Lactosylceramides;Lead;lipid metabolism;lipidomics;Lipids;Lysophosphatidylcholines;Lysosomal Storage Diseases;Lysosomes;Malignant - descriptor;Mammalian Cell;Mammary Neoplasms;Mediating;Membrane;Membrane Lipids;Metabolism;metabolomics;metaplastic cell transformation;Mitochondria;Modeling;Molecular;molecular modeling;Molecular Target;Morphology;Necrosis;neoplastic cell;Normal Cell;novel;novel anticancer drug;novel strategies;novel therapeutics;Organelles;overexpression;oxidation;Pathway interactions;Patient-Focused Outcomes;Peptide Hydrolases;Permeability;peroxidation;Pharmaceutical Preparations;Phenotype;Potassium;Production;Publishing;Reactive Oxygen Species;Recurrent tumor;Reporting;Resistance;response;Rupture;Second Messenger Systems;Secondary to;Signal Transduction;Sphingolipidoses;Sphingomyelins;stem cell population;stem cells;Supplementation;targeted treatment;Testing;Therapeutic;Therapeutic Agents;therapy resistant;Tissues;tool;tumor;Tumor Subtype

PROJECT_TITLE: Lysosomal-mitochondrial signaling in non-apoptotic cancer cell death

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: KIPKE, MICHELE D. (contact)

PROJECT_TERMS: Address;Advocacy;Advocate;African American;burden of illness;California;Child;Chronic;Chronic Disease;citizen science;Clinical;Clinical and Translational Science Awards;Collaborations;Communities;community academic partnership;community empowerment;community engagement;Community Networks;community organizations;community partners;community partnership;community research;Consultations;County;COVID-19 vaccine;design;Development;disorder prevention;disorder risk;Disparity;disparity reduction;Dyslipidemias;early-career faculty;Education;Educational workshop;Ensure;experience;Family;Family health status;forging;Fostering;Foundations;Funding;Future;Health;Health Alliance;health disparity;health equity promotion;Health Promotion;Healthcare;Healthcare Systems;improved;Institution;interest;Intervention;Language;Latino;Leadership;Los Angeles;member;mentoring community;Mission;Monitor;National Center for Advancing Translational Sciences;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Obesity;Pediatric Hospitals;peer;Pilot Projects;Play;Policies;Policy Maker;Policy Making;programs;Public Health;recruit;Research;Research Design;Research Personnel;Research Support;Role;Services;Special Supplemental Nutrition Program for Women, Infants, and Children;Training;Training Programs;Translational Research;Universities;vaccine acceptance;Work

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Clinical Research;Dystonia;Genetic Testing;Genetics;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Rare Diseases

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: PROJECT NARRATIVE  The proposed research aims to identify the neural and genetic markers of laryngeal dystonia (LD), which is a task-specific form of isolated focal dystonia characterized by involuntary spasms in the laryngeal muscles during speaking. The proposed research is relevant to public health because it is expected to have an ultimate positive translational impact on establishing the enhanced criteria for improved clinical management of LD, including its early detection and accurate diagnosis. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to developing fundamental knowledge that will help reduce the burden of human disability.

PI_NAMEs: SIMONYAN, KRISTINA  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: accurate diagnosis;accurate diagnostics;Address;Affect;Behavioral;Biological Markers;biomarker discovery;botulinum neurotoxin injection;Brain;brain abnormalities;Brain imaging;Characteristics;Classification;Clinical;Clinical Management;clinical phenotype;Communication;comorbidity;Data;deep learning algorithm;Development;Diagnosis;Diagnostic;diagnostic biomarker;Differential Diagnosis;disability;Disease;disease classification;Dysphonia;Dystonia;Early Diagnosis;early onset;endophenotype;Evaluation;Exhibits;exome sequencing;Family history of;Feeling suicidal;Focal Dystonias;Functional disorder;Funding;Future;Gene Mutation;Genes;Genetic;Genetic Markers;Genetic Predisposition to Disease;genetic variant;Genotype;Health Care Costs;Human;imaging genetics;Impairment;improved;Individual;Inherited;innovation;Knowledge;Laryngeal muscle structure;Life;Machine Learning;machine learning algorithm;Measures;Methodology;Methods;Mission;Molecular Genetics;Muscle Tension;Mutation;neural;neuroimaging;next generation;Occupational;Office Visits;Patients;Pattern;Penetrance;Phenotype;Populations at Risk;predictive marker;Production;psychiatric comorbidity;Public Health;Quality of life;reduce symptoms;Research;Risk;screening;segregation;Series;Shapes;side effect;Social isolation;Spasm;Spastic Dysphonias;Speech;Symptoms;trait;translational impact;Tremor;United States National Institutes of Health;Validation;Voice;Voice Disorders

PROJECT_TITLE: Imaging genetics of laryngeal dystonia


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SPRUIJT-METZ, DONNA D (contact)

PROJECT_TERMS: Address;Adoption;Affect;Award;California;career;career development;Child;Chronic;Chronic Disease;Clinical;Clinical Sciences;Collaborations;Communities;community engagement;community organizations;Data;Data Analyses;data management;Development;Diet;Discipline;Disparity;Dissemination and Implementation;Dyslipidemias;Elderly;Ensure;Ethnic Origin;Evaluation;experience;Faculty;Family;Feedback;Fostering;Funding;Funding Mechanisms;Goals;Government;Grant;Growth;health disparity;Health Professional;innovation;Institution;Latino;Latino Population;Leadership;Letters;Life Experience;Link;meetings;member;Mentors;Methods;Monitor;multidisciplinary;National Institute on Minority Health and Health Disparities;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;Pilot Projects;Play;prevent;Process;programs;Publications;Race;Research;research and development;Research Personnel;Research Support;Resources;Role;satisfaction;Science;Series;success;Support System;Talents;Training;Training Programs;translational approach;translational engagement;translational impact;Translational Research;Underrepresented Populations;United States National Institutes of Health;Universities;Update;voucher;Writing

PROJECT_TITLE: Investigator Development Core


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Infectious Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Despite being a primary site of infection, the human female genital tract remains largely uninvestigated in the setting of hyperacute and acute HIV infection. Utilizing unique samples obtained from the Females Rising through Education, Support and Health (FRESH) cohort, I propose to investigate both the immune response and viral dynamics that occur in the female genital tract following natural HIV exposure by leveraging RNA sequencing, microscopic imaging, and cytokine analysis techniques. This will provide new insight into HIV pathogenesis, allow for the validation of existing experimental models, and help to accelerate the development of therapeutic interventions.

PI_NAMEs: READ, BENJAMIN JOSEPH (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: Acceleration;Acute;acute infection;Africa South of the Sahara;Antigen-Presenting Cells;Area;Biological Models;Biopsy;Blood;CD4 Positive T Lymphocytes;Cells;cervicovaginal;chemokine;chronic infection;Clinical;cohort;cytokine;Data;Dendritic Cells;design;Detection;Early treatment;Education;Environment;Epidemic;Ethics;Event;Experimental Models;Female;female reproductive tract;female reproductive tract infection;Frequencies;Future;genital infection;Genitalia;Health;High Prevalence;HIV;HIV Infections;Human;human female;Image;Immune;Immune response;Immunofluorescence Immunologic;Immunologics;immunoregulation;improved;In Situ Hybridization;In Vitro;Incidence;Individual;Infection;infection burden;Infection prevention;infection risk;Inflammation;Inflammatory;Inflammatory Response;insight;Intervention;intervention effect;Literature;Methods;microscopic imaging;Modeling;Morbidity - disease rate;mortality;Mucous Membrane;nonhuman primate;Outcome;pandemic disease;Participant;Pathogenesis;peripheral blood;Phase;Plasma;Population;Prevalence;prevent;Process;Productivity;programs;Proteins;Province;reproductive tract;response;Running;Sampling;single-cell RNA sequencing;Site;Sorting;South Africa;Spatial Distribution;Structure;Systemic infection;systemic inflammatory response;T-Lymphocyte Subsets;Techniques;Testing;therapeutic development;Therapeutic Intervention;therapy development;Time;Tissues;Transcript;transcriptome sequencing;transcriptomics;Validation;Viral;Viremia;Virus Diseases;Visualization;Vulnerable Populations;young woman

PROJECT_TITLE: Immune response and viral dynamics within the female genital tract during hyperacute and acute HIV infection


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA DEPT OF AGRICULTURE/FORESTRY

ORG_STATE: LA

PHR: Project Narrative The Louisiana Department of Agriculture and Forestry (LDAF) project entitled “Enhancing the LDAF FSMA Produce Safety Program for Continued Implementation of the FDA Produce Safety Rule Utilizing Path C (State Authority)” is intended to continue previous work completed under cooperative agreement PAR-16-137 that facilitates long term implementation of the FSMA Produce Safety Rule. This work will be accomplished by: 1.Establish and maintain Project Plan and Assessment documents to guide the development of the program. 2.Establish and maintain the foundational resources, including, but not limited to, personnel, supplies, training, authority, and agreements, needed to fulfill the project plan. 3.Provide opportunities for education and outreach on the Produce Safety Rule and LDAF’s produce regulatory program to produce farms, prioritizing covered farms. 4.Maintain a complete and accurate inventory of produce farms. 5.Maintain an inspection program that focuses on quality and national consistency. 6.Maintain a compliance and enforcement program that focuses on quality and national consistency. 7.Establish and maintain a process for responding to produce-related events that are likely to result in a produce-related illness, injury or outbreak. The overall goal of this project is to strengthen the existing LDAF FSMA Produce Safety Program.This will encourage the safe production of fresh fruits and vegetables and promote high rates of compliance with the requirements of the Produce Safety Rule.

PI_NAMEs: THOMPSON, KELLY HUGHES (contact)

PROGRAM_OFFICER_NAME: VARGO, ADRIANNA

PROJECT_TITLE: Path C Enhancing the LDAF FSMA Produce Safety Program for Continued Implementation of the FDA Produce Safety Rule


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE Disease-free survival (DFS) is only achieved in 20-30% of patients with acute myeloid leukemia (AML), with relapsed or recurrent AML attributed to the drug resistant leukemic stem cells (LSCs) and drugs targeting LSCs are now of interest to achieve long-term DFS. Our studies in human AML specimens have revealed that the metabolic regulator 5' AMP-activated protein kinase (AMPK) is preferentially activated in LSCs and is critical for their viability. Therefore, we propose to develop AMPK targeted agents that may eliminate or sensitize LSCs, reducing their propensity for drug resistance and improving the efficacy of treatments such as venetoclax which may translate into durable DFS.

PI_NAMEs: REIGAN, PHILIP  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acetyl-CoA Carboxylase;Acute Myelocytic Leukemia;acute myeloid leukemia cell;AMP-activated protein kinase kinase;BCL2 gene;Binding Sites;Biological Assay;Catalytic Domain;Cell Culture Techniques;Cell Hypoxia;Cell Survival;Cells;Chemicals;chemotherapy;Clinic;Consumption;conventional therapy;Coupled;design;Development;Disease;Disease-Free Survival;Drug resistance;Drug Targeting;effective therapy;Energy Metabolism;Enzyme-Linked Immunosorbent Assay;Fluorescence Resonance Energy Transfer;Glucose;Goals;Hematopoietic stem cells;Human;Hydrophobicity;Hypoxia;improved;In Vitro;in vivo;Indazoles;inhibitor;interest;kinase inhibitor;knock-down;Lead;leukemia;leukemia treatment;leukemic stem cell;Maintenance;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;Modeling;Molecular;Monitor;Nitroimidazoles;novel;Oxidative Phosphorylation;Oxidoreductase;oxindole;Pathway interactions;patient derived xenograft model;Patients;Pattern;Peripheral;Phosphorylation;Phosphotransferases;Population;Prodrugs;Production;Property;Protac;Protein Isoforms;protein kinase inhibitor;pyridine;Pyrroles;Reactive Oxygen Species;Recurrence;Regimen;Relapse;Reporting;Research;Resistance;Role;Series;small molecule inhibitor;Specimen;stem cell survival;System;targeted agent;Therapeutic;therapeutic target;tool;Translating;Transplantation;Treatment Efficacy;tumor xenograft;Western Blotting;Xenograft Model

PROJECT_TITLE: Development of AMPK Inhibitors for the treatment of leukemia

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Climate-Related Exposures and Conditions;Clinical Research;Diabetes;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Adverse effects;Affect;Age;Air Pollutants;Air Pollution;Attenuated;Behavioral;Biological;Birth;blood glucose regulation;Breast Feeding;built environment;California;Child;Childhood;Chronic;Chronic Disease;Clinical;cohort;Communities;comparative efficacy;Continuous Glucose Monitor;County;Data;Diet;Dietary Intervention;Disease;Disease Marker;disorder risk;Disparity;disparity elimination;Dyslipidemias;early life exposure;early-life nutrition;elastography;Environment;Environmental Exposure;Environmental Risk Factor;Enzymes;Exposure to;Family;Fatty acid glycerol esters;feeding;Fibrosis;follow-up;Food Access;food environment;Funding;Future;glycemic control;Glycosylated hemoglobin A;Growth;Health;health disparity;Height;improved;indexing;Individual;Infant;Intervention;intervention effect;Juice;Latino;Latino Population;Life;Lipids;Liver;Los Angeles;Magnetic Resonance Imaging;Maternal Health;Measures;mother nutrition;Mothers;Neighborhoods;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Nutritional;Obesity;obesity in children;Outcome;Outcome Measure;Parents;Pregnancy;Progressive Disease;Public Health;randomized trial;Recurrence;Risk;Risk Factors;social;social factors;social health determinants;socioenvironmental factor;structural determinants;sugar;sweetened beverage;Toxic Environmental Substances;Toxin;Treatment Efficacy;United States National Institutes of Health;Update;Weight;Work

PROJECT_TITLE: Early Life Social, Environmental, and Nutritional Determinants of Disease (ELSEND)


NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Hypertension;Immunotherapy;Kidney Disease;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Preeclampsia, a cardiovascular and immune mediated disease in pregnancy, is the leading cause of maternal- fetal morbidity and mortality world-wide. The current proposal aims to prevent preeclampsia using a powerful, novel personalized medicine approach: cellular immunotherapy. If the cellular therapy is successful in preventing preeclampsia, the proposed project has the potential to positively impact the immediate and long-term cardiovascular health of women.

PI_NAMEs: SCROGGINS, SABRINA MARIE (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Address;Affect;Anti-Inflammatory Agents;Antigen Presentation;Antigen-Presenting Cells;Area;Argipressin;Autoimmune Diseases;Blood Pressure;Blood Vessels;Cardiovascular Diseases;cardiovascular health;Cardiovascular Physiology;Cardiovascular system;career;Cell Separation;Cell Therapy;Cells;Cellular immunotherapy;Child;Chronic;Clinical;Clinical Research;clinical translation;Clinical Trials;Complex;cytokine;Data;Dendritic Cells;Development;Discipline of obstetrics;Disease;Education;effective therapy;efficacy testing;Equilibrium;Female;fetal;Fetus;Functional disorder;Funding;Future;Generations;global health;Goals;Healthcare;Helper-Inducer T-Lymphocyte;Human;Hypertension;Immune;immune function;Immune System Diseases;Immune Tolerance;In Vitro;Inflammation;Inflammatory;Inflammatory Response;Infusion procedures;innovation;Kidney;Life;male;Mediating;Medicine;Mentors;Metabolic Diseases;Modeling;Mononuclear;Morbidity - disease rate;mortality;mouse model;Mus;Neonatal Mortality;novel;Pathogenesis;Peripheral Blood Mononuclear Cell;personalized medicine;Phenotype;Physiological;Placenta;Play;Pre-Eclampsia;Pregnancy;prevent;Prevention;Prevention approach;Prevention Measures;Prevention strategy;Prevention therapy;Preventive measure;Process;Production;programs;prophylactic;Proteinuria;Regulation;Regulatory T-Lymphocyte;Renal function;Research;Research Personnel;response;Risk;Role;Scientist;sex;Signal Transduction;skills;Symptoms;T-Cell Activation;Testing;Training;Transplant-Related Disorder;United States National Institutes of Health;Vasopressins;Vision;Wild Type Mouse;Woman;Women's Health;Work

PROJECT_TITLE: Testing the efficacy of regulatory dendritic cell treatment in the prevention of preeclampsia


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Rift Valley fever virus (RVFV) is widespread throughout the entire African continent and in some endemic areas over 50% of the population is exposed by adulthood. Activity of the innate immune system is key to mitigating the severity of disease and the virus has actively evolved ways to abrogate innate immune function. In this project we will define how biologically relevant primary human cells recognize and respond to RVFV infection, determine which innate signaling pathways function to provide protection from disease, and define the contribution of hematopoietic cell infection to in vivo pathogenesis.

PI_NAMEs: MCELROY, ANITA K (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acute;Adult;African;antagonist;Anti-viral Response;Area;Biological Response Modifiers;Cell Compartmentation;cell type;Cells;Clinical;Data;defined contribution;Disease;Encephalitis;Exhibits;Fever;Genes;Goals;Hematopoietic;Hepatitis;Hepatocyte;Human;human data;IFNAR1 gene;Immune;In Vitro;in vivo;Infection;innate immune function;innate immune mechanisms;Innate Immune Response;Innate Immune System;interferon antagonist;Interferon Inducers;Interferon Type I;Interferons;Knowledge;Macrophage;Mediating;monocyte;Mononuclear;Mus;Natural Immunity;Neurons;pathogen;Pathogenesis;Phagocytes;Population;prevent;Prevention;Production;programs;Proteins;receptor;Recombinants;Research;response;Rift Valley fever virus;Role;Secondary to;sensor;Severity of illness;Signal Pathway;Signal Transduction;Single Nucleotide Polymorphism;Testing;Tissue-Specific Gene Expression;TLR3 gene;TNF gene;Viral;Viral Pathogenesis;Virus;Virus Diseases;virus host interaction;virus identification;Virus Replication

PROJECT_TITLE: Innate immune recognition and response to Rift Valley fever virus


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Prevention;Social Determinants of Health;Violence Research

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Safe and healthy relationships are a critical aspect of adulthood yet can be inaccessible to adults with social challenges such as autism spectrum disorder. There is a significant and unmet need for assessment tools that objectively measure relationship behaviors to support effective development and evaluation of useful interventions in this domain. To achieve this, we aim to test the feasibility, sensitivity, and validity of a novel battery of performance-based behavioral, eye tracking, psychophysiological measures for adults with and without autism spectrum disorder.

PI_NAMEs: CREHAN, EILEEN TARA;FAJA, SUSAN  (contact)

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Adult;adult with autism spectrum disorder;Age;Assessment tool;Attention deficit hyperactivity disorder;autism spectrum disorder;autism symptoms;Behavior;Behavior Therapy;Behavioral;behavioral response;Clinical;Clinical Trials;Cognitive;cognitive interview;cohort;Communication;Comprehension;Control Groups;cost;Development;Diagnosis;disorder control;effectiveness study;efficacy study;Emotional;Employment;Evaluation;experience;Eye Movements;feasibility testing;Feeling;follow up assessment;Forcible intercourse;Friendships;Future;Health;Health Services Research;Heart Rate;Housing;improved;Individual;individuals with autism spectrum disorder;insight;instrument;Intellectual functioning disability;interest;Internet;Intervention;intervention program;Intervention Trial;Legal;Length;Life;Link;Loneliness;Measurement;Measures;Mental Health;Needs Assessment;novel;Outcome;Outcome Measure;Participant;Patient Self-Report;peer;Performance;Physiological;Pilot Projects;Population;Privatization;Protocols documentation;Psychophysiology;Questionnaires;Research Personnel;response;Risk;Safety;Schizophrenia;service intervention;Severities;sex;Sex Functioning;Sexual abuse;Sexual Health;sexual relationship;sexual victimization;Sexuality;skills;social;social anxiety;Social Functioning;social skills;standardize measure;Time;tool;trustworthiness;Validation;verbal;Victimization;visual tracking;Work

PROJECT_TITLE: Validation of a novel measurement battery of relationship and safety skills for adults with and without autism spectrum disorder

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: FORT WORTH

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

ORG_STATE: TX

PHR: Project Narrative Age-related neurodegenerative diseases like glaucoma have no cure and are a significant public health burden. Our research has shown that glaucoma is associated with loss of cellular energy that is amenable to metabolism-based intervention. Findings from this study will inform the development of novel therapeutics that manipulate cellular metabolism to prevent or slow the progression of glaucoma.

PI_NAMEs: INMAN, DENISE M (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Acceleration;age related neurodegeneration;Animals;Astrocytes;axonal degeneration;Biochemical;Bioenergetics;Cell Physiology;Cell Survival;cell type;Cells;Chronic;Complex;conditional knockout;Coupling;Data;Dependence;design;Detection;Development;Disease;Elements;Equilibrium;Etiology;functional decline;Functional disorder;Gene Expression;Gene Expression Regulation;gene repression;Genes;Glaucoma;Glycolysis;Goals;high intraocular pressure;Homeostasis;Human;human tissue;Hypoxia;in vivo;Incidence;Injury;innovation;insight;Intervention;Investigation;Knockout Mice;Maintenance;Mediating;Metabolic;Metabolic dysfunction;metabolic profile;Metabolism;metabolomics;Mitochondria;mitochondrial dysfunction;Modeling;mouse model;Muller's cell;Nerve Degeneration;neural;Neuroglia;Neurons;new therapeutic target;novel therapeutics;Ocular Hypertension;Optic Disk;Optic Nerve;Oxidative Phosphorylation;Oxygen;Pathology;Perfusion;Physiologic Intraocular Pressure;Physiological;Positioning Attribute;prevent;protein expression;Public Health;Recycling;Regulation;Research;resilience;Retina;retinal ganglion cell degeneration;Retinal Ganglion Cells;Stress;stressor;Testing;Therapeutic Intervention;transcriptomics;Up-Regulation;Vision;Work

PROJECT_TITLE: Metabolic Vulnerability as a Diseased Target for Glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BOUTELLE, KERRI N (contact)

PROJECT_TERMS: 10 year old;Acculturation;Address;Adherence;Adolescence;Adult;Affect;Aftercare;Age;Behavior;behavior change;Biological Markers;blood lipid;Body mass index;California;cardiometabolism;caregiver education;Caregivers;Child;Child Rearing;Chronic;Chronic Disease;comparative efficacy;Control Groups;cost;cultural values;Data;Development;Diet;Dietary intake;disorder risk;Disparity;disparity reduction;Dyslipidemias;Eating Behavior;efficacy evaluation;efficacy testing;Environmental Risk Factor;Family;family burden;Family member;family structure;Feeding behaviors;follow-up;Food;food environment;food restriction;Future;Gender;Goals;Health;health disparity;Health education;Home;Household;improved;Inflammation;Intervention;Latino;Latino Population;Life;Life Style;liver function;Mediator;member;Metabolic syndrome;Mothers;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity in children;Outcome;Outcome Assessment;Overweight;Parenting Education;Parents;Physical activity;Populations at Risk;prevent;programs;psychosocial;Randomized;randomized, clinical trials;Recommendation;recruit;response;Risk;Self Efficacy;social factors;Strategic Planning;Target Populations;telehealth;therapy development;Time;Travel;Treatment Cost;Treatment Efficacy;treatment program;United States National Institutes of Health;Visit;Weight;Weight maintenance regimen

PROJECT_TITLE: Caregivers as the Agent of Change for Childhood Obesity and Chronic Disease Risk Among Latino Families


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Services;Hydrocephalus;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSURGERY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This is a unique randomized clinical trial in Africa comparing the two best surgical options - shunt versus endoscopic - for treating post-infectious hydrocephalus, the dominant cause in African infants. Our 1-year results demonstrated that there was no disadvantage to using the more sustainable endoscopic approach over the older standard of shunt insertion, made the surprising discovery of brain growth arrest before and brain growth catch-up after treatment, and the further discovery of brain growth stagnation during the second year of follow up despite adequate control of intracranial pressure. This present project seeks to follow this unique cohort to 10 years of age, to definitively establish whether endoscopic treatment is more sustainable for infants in the developing world, establish low field MRI as a sustainable imaging technology, and establish the capacity of both the medical and engineering sites in Uganda as research and development centers for Africa.

PI_NAMEs: KULKARNI, ABHAYA V;SCHIFF, STEVEN J (contact);WARF, BENJAMIN CURTIS

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: 10 year old;Africa;African;Aftercare;Age Months;Anatomy;Brain;Brain imaging;brain volume;Cauterize;Child;Clinical;Clinical Trials;cohort;Cohort Studies;cost;cost effectiveness;Cost Effectiveness Analysis;Coupled;Data;Development;Diagnosis;Disadvantaged;empowerment;Endoscopy;Engineering;Etiology;Failure;follow-up;Funding;Goals;Growth;Health;Hydrocephalus;Image;Imaging technology;improved;Infant;Intracranial Pressure;Lead;Life;Longterm Follow-up;Magnetic Resonance Imaging;Measures;Medical;Medicine;Methods;Neurocognitive;neurodevelopment;Neurosciences Research;Nursery Schools;Operative Surgical Procedures;Outcome;Outcome Study;Patients;Pediatric Hospitals;Primary Schools;prospective;Quality of life;Quality-Adjusted Life Years;Randomized;Randomized Controlled Clinical Trials;randomized, clinical trials;Research;research and development;Resource-limited setting;School-Age Population;Science;Shunt Device;Site;Structure of choroid plexus;success;Technology;technology development;Treatment Effectiveness;trial comparing;Uganda;United States National Institutes of Health;Universities;Ventriculostomy;X-Ray Computed Tomography

PROJECT_TITLE: Neurocognitive outcomes and changes in brain and CSF volume after treatment of post-infectious hydrocephalus in Ugandan infants by shunting or ETV/CPC: a randomized prospective trial


ADMINISTERING_IC: TR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Data Science;Health Services

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PI_NAMEs: BUI, ALEX ;HARAWA, NINA THAWATA (contact);INKELAS, MOIRA

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: biomedical informatics;career;career development;clinical care;Communication;Communities;community partners;Competence;County;Data Science;dissemination science;Doctor of Philosophy;Educational Curriculum;Environment;experience;Goals;Growth;Health;health management;Health Policy;Health system;Healthcare;Healthcare Systems;implementation science;improved;Intervention;Investments;Learning;Learning Skill;Los Angeles;Medical center;member;Mentorship;Methods;National Research Service Awards;Nurses;Organizational Policy;Outcome;Pathway interactions;Phase;Physicians;population health;post-doctoral training;Postdoctoral Fellow;pre-doctoral;programs;Public Health;recruit;Research;Research Personnel;Science;Structure;System;TNFSF15 gene;Training;Translational Research;Translations;Underrepresented Minority;Woman

PROJECT_TITLE: J. NRSA Training Core


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Non-coding RNAs are known to carry out essential cellular functions and play important roles in cancer, but they are less understood compared to protein-coding genes. We propose to develop new analytical approaches and search genome-wide for novel cancer-driving non-coding RNAs in large-scale cancer genome and transcriptome sequencing data. We expect to discover new cancer drivers, biomarkers and potential drug targets.

PI_NAMEs: YANG, LIXING  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: 3-Dimensional;Affect;Algorithms;anti-cancer research;Architecture;Automobile Driving;Biological Markers;cancer cell;cancer genome;Cell Physiology;clinically significant;Code;cohort;Complex;Computational algorithm;computerized tools;Computing Methodologies;Copy Number Polymorphism;Data;Diagnosis;Disease;Disease Progression;disease-causing mutation;Distal;DNA;DNA Damage;DNA Sequence Alteration;DNA Sequence Rearrangement;DNA Shuffling;DNA Structure;drug development;Drug resistance;Drug Targeting;Enhancers;Epigenetic Process;Event;Exons;experience;Explosion;gene discovery;Gene Expression;Gene Fusion;Genes;Genetic Predisposition to Disease;Genome;genome sequencing;genome wide screen;genome-wide;Genomics;Goals;High-Throughput Nucleotide Sequencing;Human Genome;improved;In Vitro;in vivo;innovation;International;Investigation;laboratory experiment;large scale data;Life;Malignant Childhood Neoplasm;Malignant Neoplasms;Modeling;Molecular;Mutation;National Cancer Institute;Neoplasm Metastasis;new therapeutic target;novel;Oncogenes;Oncogenic;Oncologist;Pathway interactions;Patients;Pharmaceutical Preparations;Play;Ploidies;Point Mutation;Population;Prognosis;Property;Proteins;rare genetic disorder;Recurrence;Regulation;Regulatory Element;repaired;Research Design;response;Role;Technology;Testing;Transcript;transcriptome sequencing;tumor;tumor growth;tumor heterogeneity;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;Tumor Tissue;tumorigenesis;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: Unveiling non-coding drivers of cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Immunotherapy

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Caspase-1 plays a key role in the innate immune response to bacterial and viral threats, and disruption of caspase-1 regulation is associated with various immune-mediated disorders and cancer. Caspase-2 has also been linked to the innate immune system and is known as a tumor suppressor. Because the mechanism of caspase-1 and caspase-2 activation are not well known, the goal of this research is to uncover the mechanistic basis of caspase-1 and caspase-2 activation, which can lead to the development of therapeutics for immune related disorders and cancer.

PI_NAMEs: TAABAZUING, CORNELIUS  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immune response;Advisory Committees;Amplifiers;Apoptosis;Autoimmune Diseases;Autoimmunity;cancer immunotherapy;CASP1 gene;CASP2 gene;Caspase;Cell Death;Cessation of life;chemotherapy;Consensus;cytokine;Data;Dipeptidyl Peptidases;Disease;DNA;DNA Damage;Feedback;fighting;Flagellin;functional genomics;Genotoxic Stress;Germ Lines;Goals;human disease;IL18 gene;Immune;immune activation;Immune system;Immunomodulators;immunoregulation;Immunotherapeutic agent;improved;Induction of Apoptosis;Inflammasome;Inflammatory;inhibitor;Innate Immune Response;Innate Immune System;insight;Knowledge;Link;Malignant Neoplasms;Mediating;Mentors;microbial;Modeling;Molecular;multicatalytic endopeptidase complex;Multiprotein Complexes;N-terminal;novel;Outcomes Research;pathogen;Pathogenicity;Pattern recognition receptor;Peptide Hydrolases;Phase;Play;Process;Proteins;Proteomics;Publishing;recruit;Regulation;Research;response;RNA;Role;sensor;Series;Serine Protease;Signal Transduction;skills;small molecule inhibitor;Stimulus;Stress;Structure;Testing;Therapeutic;therapeutic development;therapeutic protein;therapeutic target;Training;Tumor Suppressor Proteins;ubiquitin-protein ligase;Ubiquitination;UV Radiation Exposure;VDAC1 gene;Viral;Work

PROJECT_TITLE: Investigating the function of ZU5 domain-containing proteins as amplifiers of caspase activation


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: COHEN, DEBORAH A (contact)

PROJECT_TERMS: 10 year old;acceptability and feasibility;Address;Adult;Affect;Age;aged;blood lipid;Blood Pressure;blood pressure reduction;Blood specimen;Body mass index;Body Weight decreased;Budgets;California;Child;Child Health;Chronic;Chronic Disease;cognitive function;community engagement;cost;Crossover Design;Cues;Data;Development;Diet;dietary;Dietary intake;disorder risk;Disparity;Dyslipidemias;Eating;Economics;efficacy testing;Electronics;Enrollment;Environmental Risk Factor;Enzymes;Family;Family member;Focus Groups;Food;Glycosylated hemoglobin A;Goals;Guidelines;Health;health disparity;Home;Home environment;Household;improved;Impulsivity;Incentives;Individual;Intervention;intervention delivery;Latino;Latino Population;Link;Lipids;Liver;liver function;Logistics;Los Angeles;Low income;Marketing;Measurement;member;Mental Fatigue;Menu Planning;Modeling;negative affect;Neighborhoods;New York City;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;nutrition;Nutritional;Obesity;obesity in children;Overweight;Participant;Personal Satisfaction;Persons;Pilot Projects;Population;Prediabetes syndrome;primary outcome;Process;programs;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Recommended Dietary Allowance;Research Personnel;response;Restaurants;Risk;Risk Reduction;secondary outcome;service delivery;sex;social;social factors;sugar;Supermarket;Testing;trend;Unhealthy Diet;United States Department of Agriculture;Waiting Lists;Weight;weight maintenance;Weight maintenance regimen

PROJECT_TITLE: Food Prescriptions to Promote Affordable Diets that Meet RDAs Among Multi-Generational Latino Households


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Contraception/Reproduction;Diethylstilbestrol (DES);Endocrine Disruptors;Estrogen;Genetics;Infertility;Prevention;Women's Health Research

ORG_DEPT: VETERINARY SCIENCES

PHR: Mechanisms of Ovarian Endocrine Disruption at Single-Cell Resolution Developmental exposures to endocrine disrupting chemicals (EDCs) such as dichlorodiphenyltrichloroethane (DDT) are associated with reproductive disease and impaired fertility across species. Yet, exact molecular mechanisms explaining how environmentally relevant exposures during key windows of ovarian differentiation elicit long-term effects on female fertility remain unclear. The proposed work pairs a translational fish model with cutting-edge single cell transcriptomics to define long-term functional and molecular consequences of DDT exposure on cell types and gene regulatory networks in the developing ovary.

PI_NAMEs: COSSABOON, JENNIFER MONIQUE (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Adult;analytical tool;androgenic;Binding;Biological Assay;Biological Markers;Breast Cancer Risk Factor;Breeding;cancer risk;Cell Differentiation process;cell type;Cells;Chemical Exposure;Chemicals;contaminated water;Country;Data;Daughter;Development;dichlorodiphenyltrichloroethane;Diethylstilbestrol;Disease;Dose;Economics;egg;Embryo;Endocrine disruption;Endocrine Disruptors;Endocrine System Diseases;Environment;Environmental Estrogen;Environmental Exposure;Enzymes;Estrogen Receptors;estrogenic;Estrogens;Ethics;Experimental Models;experimental study;exposed human population;Exposure to;Female;female fertility;Fertility;Fertilization;fetal;Fishes;Gene Expression Regulation;gene regulatory network;Genes;Genetic;Genetic Transcription;Genome;genotypic sex;gonad development;Gonadal Steroid Hormones;Gonadal structure;Health;high risk;Histology;hormonal signals;Hormone Receptor;Hormones;Human;Hypothalamic structure;Impairment;in utero;in vivo;in vivo Model;individual response;Infertility;innovation;insight;Isomerism;Japanese Killifish;Knowledge;Larva;Life;Life Cycle Stages;life span;lipophilicity;Long-Term Effects;Mammals;Masks;Maternal Exposure;Measures;Mediating;Metabolism;Modeling;Molecular;Nature;novel;Nuclear Hormone Receptors;Onset of illness;oocyte maturation;Oocytes;organ growth;organochlorine pesticide;Oryziinae;Ovarian;Ovarian Diseases;Ovarian Follicle;Ovary;Parents;Pathway interactions;Pesticides;Physiological;Pituitary Gland;Poison;Population;Pregnancy Rate;prenatal exposure;Production;Public Health;reproductive;reproductive system disorder;reproductive system neoplasm;Research;Resolution;Risk;Role;screening;Sequence Homology;sex;sex determination;sexual dimorphism;Signal Transduction;single cell mRNA sequencing;Somatic Cell;Sorting;Steroid biosynthesis;steroid hormone;Testing;Toxicology;transcriptome sequencing;transcriptomics;translational model;Woman;Work;xenoestrogen;Zebrafish

PROJECT_TITLE: Mechanisms of ovarian endocrine disruption at single-cell resolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-B(20)L]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Networking and Information Technology R&D (NITRD);Primary Health Care;Telehealth

ORG_CITY: MADISON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE In addition to their debilitating impact on health and well-being, multiple chronic conditions such as diabetes and hypertension account for 90% of Medicare spending. This project will test the ability of voice-controlled "smart" technology to deliver an already proven electronic health system (Elder Tree, or ET) for these patients; specifically, we hypothesize that older patients using ET on a smart display and speaker combination will experience even greater improvement in health factors including physical function, pain, depression, medical symptoms, loneliness, and healthcare use than will patients using ET on a laptop, because voice technology enables such easy use, thereby increasing use of the system. The proposed study will have far-reaching implications for the use of voice-assisted technology for the broad spectrum of eHealth interventions currently becoming available.

PI_NAMEs: GUSTAFSON, DAVID H (contact);MARES, MARIE-LOUISE

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Accounting;Address;Adopted;Adult;Age;Anxiety;arm;beneficiary;Chronic;Clinical;Communication;Competence;computer science;Control Groups;cost;Development;Devices;Diabetes Mellitus;eHealth;Elderly;electronic health system;Elements;Engineering;evidence base;expectation;experience;Fatigue;follow-up;Funding;Geriatrics;Goals;Health;Health Care Costs;health management;Health system;Healthcare;Healthcare Systems;Hearing;human old age (65+);Hyperlipidemia;Hypertension;improved;intelligent personal assistant;Intention;Internet;Intervention;intrinsic motivation;laptop;literacy;Loneliness;Marketing;Measures;Mediating;Mediator;Medical;Medicare;men;Mental Depression;Motivation;multiple chronic conditions;Obesity;older adult;older patient;Outcome;Pain;Patients;Personal Satisfaction;Phase;Physical Function;Prediabetes syndrome;pressure;prevent;Primary Care;primary care clinic;primary outcome;Procedures;programs;Quality of life;Randomized;randomized trial;randomized, clinical trials;Reading;Research;Research Personnel;response;Science;secondary outcome;Self Determination;Self Management;Services;skills;Sleep disturbances;smart speaker;smart technologies;social;success;Symptoms;System;Technology;Testing;theories;therapy design;Time;tool;Trees;Tremor;United States Agency for Healthcare Research and Quality;Universities;video chat;Vision;Visual;Voice;Walking;Wisconsin;Woman

PROJECT_TITLE: Using Smart Displays to Implement an Evidence-Based eHealth System for Older Adults with Multiple Chronic Conditions

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(OA)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Data Science;Heart Disease;Precision Medicine;Social Determinants of Health

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: NARRATIVE  This project is relevant to public health because we will collaborate with the NHLBI and the HeartShare Network to generate new knowledge regarding unique subtypes of heart failure with preserved ejection fraction and underlying mechanisms to ultimately improve patient outcomes. Specifically, the CHIcago Center for Accelerating nextGen Omics, deep phenotyping, and data science in Heart Failure (CHICAGO-HF) proposes to contribute to the development of retrospective and prospective cohorts of patients with heart failure with preserved ejection fraction and controls. We aim to strengthen the Network through our considerable experience and expertise in epidemiology, informatics, magnetic resonance imaging, and artificial intelligence.

PI_NAMEs: KHAN, SADIYA SANA (contact);RASMUSSEN-TORVIK, LAURA J

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Abdomen;Acceleration;Address;Adult;Affect;Age;Artificial Intelligence;Biology;Biopsy;Body System;Cardiac;Chicago;Clinical;clinical center;Clinical Research;cohort;Collaborations;community collaboration;community partners;comorbidity;Complex;Data;Data Analytics;Data Science;data warehouse;Dedications;Development;Dimensions;Disease;Disparity;Echocardiography;effective therapy;EFRAC;Electronic Health Record;Elements;Environment;Epidemiology;Equity;ethnic minority;Ethnic Origin;Exercise;experience;Federally Qualified Health Center;Four-dimensional;Functional disorder;Funding;Genomics;Geography;Goals;Health Expenditures;Heart failure;heart failure with reduced ejection fraction;Heterogeneity;Illinois;improved;improved outcome;Informatics;Infrastructure;innovation;insight;Institution;Knowledge;Lead;Magnetic Resonance Imaging;Mission;Morbidity - disease rate;mortality;multidisciplinary;Multimodal Imaging;Myocardial;Myocardial perfusion;Myocardium;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;Nature;Network-based;new therapeutic target;next generation;Observational Study;Outcome;patient population;Patient-Focused Outcomes;Patients;Phase;phenomics;Phenotype;Population Heterogeneity;Positioning Attribute;precision medicine;Precision Medicine Initiative;preservation;Prevalence;prevent;programs;prospective;Prospective cohort;Protocols documentation;Public Health;Public Health Informatics;Qualifying;Race;racial minority;Randomized, Controlled Trials;recruit;Research;Resources;response;Retrospective cohort;Sampling;Science;sex;Site;Skeletal Muscle;Socioeconomic Status;Sodium;success;support network;Syndrome;targeted treatment;Techniques;Testing;therapeutic target;timeline;Tissues;tool;Trans-Omics for Precision Medicine;Translating;United States National Institutes of Health;Woman;Work


ORG_CITY: MANHATTAN

ORG_NAME: KANSAS STATE DEPARTMENT OF AGRICULTURE

PHR: Project Narrative The Kansas Department of Agriculture will be able continue to operate the Produce Safety Program in the Division of Food Safety and Lodging with the funding provided by this Cooperative Agreement. The Program maintains the Kansas Produce Farm Inventory, develops programmatic policies and procedures in compliance with FDA requirements, and performs produce farm inspection under FDA commissioning/credentialing. The Kansas Department of Agriculture Produce Safety Program is seeking funding under PATH B, as specified in the Cooperative Agreement Notice of Award.

PI_NAMEs: GRISAMORE, AMBER A (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, ANDREA

PROJECT_TITLE: Path B Kansas Department of Agriculture Produce Safety Program for theImplementation of the CFR Title 21 PART 112


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Dissemination and Implementation Research;Pediatric;Rehabilitation

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative Individuals who cannot use speech and use augmentative and alternative communication (AAC; pointing to pictures, using a speech-generating device) have limited opportunities in phonics-based literacy instruction. Acquiring even basic literacy skills can lead to increased employment opportunities, improved safety and well- being, and enhanced social engagement. This project aims to investigate the efficacy, feasibility, acceptability, and adoptability of a technology-mediated phonics-based literacy intervention (ALL; Accessible Literacy Learning) to increase six basic literacy skills of individuals who use AAC.

PI_NAMEs: CARON, JESSICA G. (contact)

PROJECT_TERMS: Address;Adopted;Adoption;Adult;Age;alternative communication;Area;Attitude;Augmentative and Alternative Communication;autism spectrum disorder;Awareness;base;Cerebral Palsy;Child;Communication;Control Groups;Data;Decision Making;Developmental Disabilities;Devices;disability;Down's Syndrome;Educational Curriculum;Educational process of instructing;Effectiveness;effectiveness evaluation;effectiveness research;efficacy evaluation;Employment Opportunities;evidence base;Evidence based practice;Future;Goals;Health;Health Care Costs;high risk;high school;illiteracy;illiterate;implementation barriers;implementation fidelity;improved;Individual;innovation;Instruction;Intellectual functioning disability;Intervention;Interview;Learning;Letters;Link;literacy;Measures;Mediating;Memory;Methods;Outcome;Output;Participant;Perception;Personal Satisfaction;Pilot Projects;Population;Printing;Probability;Public Health;Questionnaires;Reading;Recommendation;Research;Safety;Science;service providers;skill acquisition;skills;social engagement;sound;Speech;tau Proteins;Technology;Time;Training;treatment group;uptake;virtual vocal tract;Vision;Work

PROJECT_TITLE: Improving Literacy Outcomes in Children who use AAC

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ORG_DEPT: CHEMISTRY

PHR: Project Narrative: While membrane proteins are important, constituting ~23% of the human proteome and more than 60% of current drug targets, little is known about how the cooperative action among different types of membrane proteins can be coordinated at the cell surface to precisely control the sensitivity and specificity of the downstream signaling. Our recent discovery has revealed a novel molecular mechanism by which a recently discovered spectrin-actin- based membrane skeleton structure can coordinate the interactions among major types of membrane receptors in neurons, giving rise to the downstream intracellular signaling. The goal of this proposed research is to reveal the distinctively physical molecular mechanisms by which this spectrin-actin-based membrane skeleton brings the selected groups of membrane proteins in proximity to form signaling protein complexes at the cell surface, and the results from the proposed research will not only deepen our understanding of how the subcellular compartmentalization of signaling proteins can be spatiotemporally controlled to dictate a specific signaling outcome, but also potentially inspire new strategies for the therapeutic intervention of human diseases.

PI_NAMEs: ZHOU, RUOBO  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Actins;Affect;Behavior;Binding;Biochemical;biophysical properties;Bone structure;Cell Communication;Cell Differentiation process;Cell membrane;Cell Proliferation;Cell surface;Cell Surface Proteins;Cell Survival;cell type;Cell-Adhesion Molecule Receptors;Cells;Cellular biology;Clinical;Development;Disease;Drug Targeting;Endocytosis;Eukaryotic Cell;extracellular;Family;first responder;G protein coupled receptor kinase;G-Protein-Coupled Receptors;Goals;Human;human disease;Immune;Immune response;insight;Intracellular Membranes;Liquid substance;Lymphocyte;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Membrane;Membrane Proteins;membrane skeleton;Metabolism;Molecular;Molecular Biology;Mutation;nanocluster;Neurodegenerative Disorders;Neurons;novel;novel therapeutic intervention;Organelles;Outcome;Periodicals;Phase;protein complex;Protein Family;Proteins;Proteome;receptor;Receptor Protein-Tyrosine Kinases;Research;Role;Sensitivity and Specificity;Signal Pathway;Signal Transduction;Signaling Protein;Site;Skeleton;spatiotemporal;Spectrin;Stimulus;superresolution imaging;Syndrome;targeted treatment;Therapeutic Intervention;therapy design;tool;Transactivation

PROJECT_TITLE: Deciphering the functional role of actin-spectrin-based membrane skeleton in subcellular compartmentalization of signaling proteins and cell signal transduction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Nutrition;Substance Misuse

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Overconsumption of sodium is a serious risk factor of cardiovascular and cognitive malfunction. This project will examine the brain circuit that mediate sodium appetite and consequent ingestion. The proposed research is relevant to public health because it will provide insights into the function and dysfunction of sodium regulatory mechanisms that optimizes dietary sodium intake.

PI_NAMEs: OKA, YUKI  (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Action Potentials;Acute;Aldosterone;Anatomy;Angiotensins;Animals;Appetite Regulation;Area;Behavior;Behavior Control;Biological Process;biomarker identification;Blood;Brain;cardiovascular risk factor;Cell Nucleus;cell type;Cells;Cognitive;Consumption;craving;design;Desire for food;Dietary Sodium;Electrophysiology (science);Equilibrium;experimental study;Feeding behaviors;Functional disorder;gain of function;Genetic;genetic information;Genetic Markers;Goals;hedonic;Hemostatic function;hindbrain;Homeostasis;Hunger;Impaired cognition;Individual;Ingestion;insight;Intake;Ions;Lamina Terminalis;locus ceruleus structure;Logic;loss of function;Maps;Mediating;Modeling;Molecular;Molecular Genetics;Mus;Negative Valence;neural;neural circuit;Neural Pathways;Neurons;Neurosciences;Nucleus solitarius;optogenetics;Osmolalities;Osmoregulation;Pathway interactions;Physiological;Pilot Projects;Population;Population Control;Positive Valence;preference;Process;Prosencephalon;Public Health;Publishing;Regulation;Research;Risk Factors;Role;Salts;Signal Transduction;Site;Sodium;Sodium Chloride;Synaptic Transmission;Techniques;Testing;Thirst;tool;transcriptomics;Vascular Diseases;Viral;Virus;Water;Work

PROJECT_TITLE: Dissecting sodium appetite circuits in the mammalian brain


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Serious Mental Illness;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Adults with serious mental illness (SMI) have a disproportionate rate of involvement with the criminal justice system and are at high risk of recidivism, but there are no clinical interventions available in community mental health settings that specifically address criminogenic risk factors. The proposed study will finalize the development of a criminogenic focused intervention for use with people with SMI in community mental health settings and test it in a pilot randomized controlled trial. We will also gather critical input from a variety of mental health and criminal justice system stakeholders to aid in the design of implementation strategies to expediate and optimize its scalability and sustainability in community settings.

PI_NAMEs: WILSON, AMY BLANK (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Address;Administrator;Adoption;Adult;Aggressive behavior;Attitude;behavioral health;Belief;Client;Clinical;Clinical Treatment;Clinical Trials;Cognitive Therapy;Communities;community intervention;community setting;Criminal Justice;Development;Effectiveness;effectiveness trial;effectiveness/implementation trial;evidence base;Face;Failure;flexibility;Focus Groups;forging;Funding;Funding Agency;Future;future implementation;Goals;Health system;high risk;implementation design;implementation strategy;Imprisonment;Impulsivity;Individual;information gathering;innovation;Intervention;intervention delivery;Interview;Investigational Therapies;Justice;Light;Mediating;Mental disorders;Mental Health;Mental Health Services;Methodology;Methods;Mission;National Institute of Mental Health;novel;Outcome;parole;Persons;Phase;Pilot Projects;pilot trial;preventive intervention;primary outcome;Prisoner;probation;Process;Public Health;Qualitative Research;Randomized, Controlled Trials;recidivism;Research;Research Methodology;Risk;Risk Factors;service intervention;service providers;Service provision;Services;severe mental illness;Structure;Supervision;Symptoms;System;Testing;Therapeutic Intervention;therapy development;Thinking;treatment as usual;usability;user centered design

PROJECT_TITLE: Forging New Paths: Building Interventions to Treat Criminogenic Needs in Community Based Mental Health Settings


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Obesity;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: BOSTON

PHR: Project Narrative Childhood obesity remains highly prevalent in the United States and is a major contributor to chronic disease, but multiple socioeconomic and geographic barriers exist for children that impact access to care. Telehealth is an approach that can improve access and participation but known telehealth barriers must be examined and addressed prior to implementation. This career development award will examine telehealth approaches for childhood obesity to understand multi-level factors that impact access and participation in care and adapt a pediatric weight management program for telehealth.

PI_NAMEs: SIMIONE, MEG  (contact)

PROGRAM_OFFICER_NAME: BRUNO, FERNANDO PEREIRA

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Age;Body mass index;Cardiometabolic Disease;career;career development;Caring;Characteristics;Child;Child health care;Childhood;Chronic Disease;Client;Clinical;clinical practice;Clinical Trials;Consolidated Framework for Implementation Research;Data;design;digital health;Effectiveness;effectiveness evaluation;Electronic Health Record;Employment;Equity;ethnic diversity;Ethnic Origin;experience;Family;Funding;General Hospitals;geographic barrier;Goals;Health;health care delivery;health care quality;health disparity;health equity;health literacy;Health Services Accessibility;Healthcare;heart disease prevention;high risk;Household;Housing;implementation evaluation;implementation framework;implementation research;implementation science;implementation strategy;Improve Access;improved;Inequity;innovation;Insurance;Internet;Interview;K-Series Research Career Programs;Language;Low income;Massachusetts;Measures;Mentors;Mentorship;Methods;Mission;multidisciplinary;National Heart, Lung, and Blood Institute;Neighborhood Health Center;Obesity;obesity in children;Outcome;Parents;Participant;Patient-Focused Outcomes;Patients;Persons;pilot test;Prevention;primary care visit;programs;public health insurance;Race;racial diversity;Research;Research Institute;Research Personnel;Research Project Grants;Risk Factors;satisfaction;Scientist;Services;skills;social;socioeconomics;telehealth;Testing;Training;United States;Visit;Weight maintenance regimen

PROJECT_TITLE: Adapting a pediatric weight management program for implementation via telehealth

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The overarching goal of this translational research project is to develop a new immunotherapeutic nanoparticle for intrapleural administration, aimed at mitigating the immune cold environment in malignant pleural effusion (MPE) to enhance therapeutic efficacy of anti-PD-L1 immune checkpoint blockade (ICB). Intrapleural delivery of antigen presenting cells (APCs)-targeted nanoparticle loaded with STING agonist (LNP-STING) is expected to elicit APC-mediated immune sensing of tumor antigens and cross-priming of effector T cells, thus setting a stage for favorable response to anti-PD-L1 ICB. We will test the combination immunotherapy of intrapleural LNP- STING plus anti-PD-L1 in vivo in a mouse model of MPE, and ex vivo with clinical MPE samples, and importantly, gain insights into the immunobiological mechanisms of LNP-STING interacting with the complex tumor microenvironment in MPE.

PI_NAMEs: LU, YONG ;ZHAO, DAWEN  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Address;Agonist;anti-cancer;anti-PD-L1;antibody-dependent cell cytotoxicity;Antigen-Presenting Cells;Binding;Biological;Biological Assay;calcium phosphate;cancer immunotherapy;Cancer Patient;CD8-Positive T-Lymphocytes;Cells;chemotherapy;Clinical;clinical development;Clinical Trials;Combination immunotherapy;Combined Modality Therapy;Complex;Cross-Priming;Cytosol;cytotoxic;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;Drug Kinetics;effector T cell;effusion;Environment;Enzymes;fighting;Foundations;Gene Activation;Gene Conversion;gene interaction;Goals;IgG1;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune Targeting;Immunity;Immunologics;Immunology procedure;Immunophenotyping;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Incubated;Inflammatory;Injections;insight;interest;Interferon Type I;Ligation;Liposomes;lung cancer cell;Macrophage;Malignant - descriptor;Malignant Neoplasms;Malignant Pleural Effusion;Mediating;Modeling;mouse model;Mus;nanoparticle;Natural Killer Cells;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;Operative Surgical Procedures;palliative;Pathway interactions;Patients;PD-1/PD-L1;Phenotype;Phosphatidylserines;phosphoric diester hydrolase;Play;Pleural cavity;preclinical study;Predisposition;Production;Prognosis;Property;Rationalization;Research Project Grants;response;Role;Sampling;Secondary to;Signal Transduction;single-cell RNA sequencing;Solid Neoplasm;Specificity;standard of care;Stimulator of Interferon Genes;T cell infiltration;T-Lymphocyte;targeted delivery;Testing;Therapeutic Effect;therapeutic evaluation;Tissues;Toxic effect;translational goal;Treatment Efficacy;tumor;Tumor Antigens;Tumor Burden;Tumor Immunity;tumor microenvironment;Tumor Promotion;tumor-immune system interactions;uptake;Work

PROJECT_TITLE: Intrapleural immunotherapeutic nanoparticles for MPE treatment