NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: NARRATIVE The overall goal of this proposal is to provide investigators at the Medical University of South Carolina with a supercomputer. This high-performance computer will be capable of efficiently performing artificial intelligence techniques such as machine learning and deep learning. By providing these resources, we will accelerate healthcare research at MUSC, help investigators from different fields to work together and share their data and expertise, and ultimately improve population health through rapid translation of research to clinical care.

PI_NAMEs: LENERT, LESLIE A. (contact)

PROJECT_TERMS: Area;Artificial Intelligence;Big Data;Clinical;cluster computing;computer infrastructure;computing resources;Data;data centers;data resource;Data Set;Data Storage and Retrieval;Dedications;deep learning;Electronic Health Record;Funding;genome resource;genomic data;Health;Healthcare Systems;High Performance Computing;high resolution imaging;Image;Infrastructure;Institution;instrument;Laboratories;Link;Machine Learning;Medical;multiple omics;Picture Archiving and Communication System;Request for Proposals;Research;Research Personnel;Research Project Grants;Resources;South Carolina;synergism;Techniques;Translations;transmission process;United States National Institutes of Health;Universities

PROJECT_TITLE: Integrating Multi-Omics into Ongoing NIH Research through Artificial Intelligence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-V (32)]


ADMINISTERING_IC: OD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative Both human disease and healthy human development are driven by intricate events occurring at the nanoscale within cells. The Zeiss LSM 980 with Airyscan 2 uses cutting-edge developments in fluorescent microscopy to let researchers at the University of Rochester peer inside the cell at smaller length scales, faster time scales, and for longer periods of time. This technology will have a transformative impact on ongoing NIH-funded research into how developing organisms form proper tissues, which molecular elements drive evolution, how pathogens cross from the bloodstream into tissues, how cells organize their DNA.

PI_NAMEs: ABBONDANZIERI, ELIO AARON (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Aging;Area;base;Biological;biological systems;Biology;Cell Differentiation process;Cells;Confocal Microscopy;cost;DNA;fluorescence microscope;fluorophore;functional genomics;Funding;Future;Goals;Image;imaging capabilities;improved;innovation;instrument;interest;Lasers;Microscope;Microscopy;Molecular;Noise;Optics;Phase;Phototoxicity;Physical condensation;Research;Research Personnel;Resolution;Resources;Scanning;Scientist;Signal Transduction;single molecule;Speed;Techniques;Technology;temporal measurement;trafficking;ultra high resolution;United States National Institutes of Health;Universities

PROJECT_TITLE: Zeiss LSM 980 with Airyscan2 for Studies of Biological Systems at the University of Rochester

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (30)]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: NEW YORK

ORG_NAME: ADVANCED SCIENCE RESEARCH CENTER

PHR: PROJECT NARRATIVE  This instrument will support biomedical research projects of twelve laboratories from within CUNY and nearby institutions, including investigators from the Structural Biology and Neuroscience Initiatives at the ASRC, neighboring institutions in New York, and other laboratories located throughout the region and nation. The anticipated outcomes are improved instrumental sensitivity, resolution, and other technical capabilities that will enable a diverse range of currently inaccessible experiments into fundamental mechanisms of biological control, critical for understanding life and disease at the molecular and level with implications for therapeutic and biotechnology applications.

PI_NAMEs: ABZALIMOV, RINAT  (contact)

PROGRAM_OFFICER_NAME: CHEN, YONG

PROJECT_TERMS: Affect;Area;axon regeneration;Biochemistry;Bioenergetics;Biological Process;Biology;Biomedical Research;Biotechnology;Blood Platelets;brain cell;career;Cell Differentiation process;Cities;college;Detection;Deuterium;dietary;Disease;epigenetic regulation;Funding;Hydrogen;Image;In Situ;insight;Institution;instrument;instrumentation;Integrins;interest;ion mobility;ion source;Isomerism;Joints;Laboratories;Light;macromolecular assembly;Macromolecular Complexes;Maps;mass spectrometer;Mass Spectrum Analysis;Measurement;Metabolic;Metabolic Control;metabolomics;Molecular;Molecular Conformation;Molecular Profiling;Nerve Degeneration;Neuroglia;Neurosciences;new technology;New York;New York City;novel;Outcome;Phosphotransferases;Population Dynamics;Process;programs;Proteins;Proteomics;Research;Research Personnel;Research Project Grants;Resolution;Route;Ryanodine Receptor Calcium Release Channel;Science;Scientist;Signal Transduction;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;structural biology;System;Technology;Therapeutic;Tissues;tool;training opportunity;tumor progression;United States National Institutes of Health;Universities

PROJECT_TITLE: TimsTOF-fleX MALDI-2 mass-spectrometer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-T (30)]


ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative This grant will provide the University of California at Berkeley with a state-of-the-art light sheet microscope to enable rapid time-lapse, multi-sample volumetric imaging of live specimen in their native environment. This unique instrument is perfectly suited for the studies of fly, fish and mouse embryos, a diverse range of organoid systems and tissue explants, which are critical to biomedical research discovery.

PI_NAMEs: HE, LIN  (contact)

PROJECT_TERMS: 3-Dimensional;Biomedical Engineering;blastocyst;cell behavior;Cell division;cell motility;Cell Physiology;Cell Volumes;Cells;Cellular biology;design;Detection;Development;Developmental Process;Embryo;Embryonic Development;Environment;experimental study;fly;Grant;high resolution imaging;Human;Image;imager;imaging Segmentation;Imaging technology;improved;instrument;Laser Scanning Confocal Microscopy;lens;Light;Lighting;Measurement;Microscope;Molecular;Molecular Biology;Mus;novel;Optics;Optometry;Organism;Organoids;Pathologic Processes;Photobleaching;photodestruction;Phototoxicity;Physics;Physiological Processes;Positioning Attribute;quantitative imaging;Research;Research Personnel;Resolution;Sampling;Schools;Side;Signal Transduction;Specimen;System;temporal measurement;Tissues;Zebrafish

PROJECT_TITLE: Instrument Grant for Truelive 3D


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: TOLEDO

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

ORG_STATE: OH

PHR: Project Narrative This is a shared instrumentation grant application to acquire a BD FACSymphony S6 flow cytometer to replace a 16-year-old BD FACS Aria™ IIu for the University of Toledo Flow Cytometry Core. The BD FACSAria™ IIu is the only cell sorter available and services both the UToledo Health Science and Main Campus research communities and is on end- of-life service and support. Acquisition of a new state of the art flow cytometer will be operated as a shared resource to accelerate the health-related research of nine major users who are engaged in NIH-sponsored projects focused on virology, cancer, hypertension, transplantation, immune response to infection and arthritis.

PI_NAMEs: KALINOSKI, ANDREA LYNN (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: 16 year old;Applications Grants;Award;Biomedical Research;Cells;Cellular biology;college;Communities;Consultations;Core Facility;Cost Sharing;Development;end of life;Environment;Experimental Designs;experimental study;Faculty;Failure;Flow Cytometry;Funding;Future;Generations;Goals;graduate student;Health Sciences;Immunology;improved;innovation;Institution;instrument;instrumentation;Manufacturer;medical schools;Minor;Molecular Biology;Pathology;Play;recruit;Research;Research Activity;Research Training;Resources;Role;Scientific Advances and Accomplishments;Services;Students;Talents;Technology;tool;Training;Training Support;Translational Research;Underrepresented Students;United States National Institutes of Health;Universities;virology

PROJECT_TITLE: Acquisition of a FACSymphony S6 Sorter for the University of Toledo Flow Cytometry Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-D (30)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_CITY: LA JOLLA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: We are requesting funds for a ZetaView® x30 QUATT Multi-Fluorescence Nanoparticle Tracking Analyzer. This instrument is essential to biomedical research involving extracellular vesicles. Providing local researchers with access to this instrument will expand state-of-the-art technologies, enable new methodologies, and facilitate synergistic discoveries in multiple fields at UC San Diego and the surrounding area.

PI_NAMEs: WANG, SHIZHEN EMILY (contact)

PROJECT_TERMS: Advisory Committees;Area;Biomedical Research;Cancer Center;Cardiac;career;Communities;Contract Services;Diabetes Mellitus;Diagnostic;Embryonic Development;Environment;Event;extracellular vesicles;Faculty;Fluorescence;Funding;Health Sciences;Homeostasis;improved;Institution;instrument;Investments;Laboratories;Lasers;Malignant Neoplasms;Measurement;medical schools;Metabolic Diseases;Methodology;Minor;Molecular;nanoparticle;Neurosciences;Obesity;Online Systems;particle;Pathology;Pharmacologic Substance;Pharmacy Schools;Phenotype;prenatal;Reporting;Research;Research Personnel;Reservations;Resources;RNA marker;Running;Schools;Science;Services;Signal Transduction;Technology;therapeutic development;Time;United States National Institutes of Health;zeta potential

PROJECT_TITLE: ZetaView x30 QUATT Multi-Fluorescence Nanoparticle Tracking Analyzer


ADMINISTERING_IC: VA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

PHR: At least 250,000 individuals in the United States have a spinal cord injury (SCI), with approximately 12,000 new cases per year, and over 15% of these individuals are veterans (VA 2009). SCI typically results in loss of bowel function. The standard of care for individuals with neurogenic bowel dysfunction involves the implementation of a bowel program for predictable, effective elimination of the bowels. The bowel routine can require over an hour to evacuate the bowels and this process typically requires the assistance of a caregiver, which adds to the cost of care and reduces independence. Restoring bowel function is considered a high priority by individuals with SCI, but remains a critically unmet need requiring further development (Anderson 2004). This project will develop a novel approach using electrical stimulation to improve bowel function. Providing improved, independent bowel control is the ultimate goal of this project, which would enhance the quality of life for veterans with SCI and reduce the financial impact on the Veteran Health Care system.

PI_NAMEs: BOURBEAU, DENNIS  (contact);COLASANTE, CESAR

PROJECT_TERMS: Acute;Animals;Anus;Blinded;care costs;Caregivers;Caring;Catheters;Chronic;Clinical;cohort;Colon;Constipation;cost;Data;design;Development;Devices;Diet;digital;Effectiveness;Electric Stimulation;Electrodes;Esthesia;Excision;experimental study;family burden;family support;Fecal Incontinence;Feces;Feedback;Fingers;follow-up;Frequencies;Functional disorder;Future;gastrointestinal;Goals;Health;Healthcare Systems;Home;Hour;human study;Implant;improved;Individual;insight;Intake;Intestines;K-Series Research Career Programs;Leg;Liquid substance;Manometry;Manuals;Mechanics;minimally invasive;Motility;Movement;Neurons;neuroprosthesis;novel strategies;Outcome Measure;Pacemakers;Participant;Pattern;Pharmacologic Substance;Phase II Clinical Trials;pressure;primary outcome;Process;programs;Quality of life;recruit;Rectum;Reflex action;Reflex control;response;satisfaction;Schedule;secondary outcome;Sensory;skills;Spinal cord injury;spinal reflex;standard of care;Structure;Suppositories;Target Populations;Testing;Time;tool;United States;Veterans;Work

PROJECT_TITLE: Electrical rectal stimulation to promote bowel emptying after spinal cord injury

STUDY_SECTION: RRDA

STUDY_SECTION_NAME: Spinal Cord Injury/Disorders & Neuropathic Pain[RRDA]


ORG_CITY: NEW ORLEANS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE This proposal would provide funds for a state-of-the-art small animal imaging system at Tulane University. Major and minor users in support of the proposal perform research in women’s health, cardiovascular health, reproductive medicine and biology, neurological diseases, renal health, and oncology. The establishment of a small animal ultrasound imaging core system at Tulane would greatly advance the users’ NIH-funded research programs.

PI_NAMEs: BAYER, CAROLYN LOUISE (contact)

PROJECT_TERMS: 10 year old;Aging;Animals;Architecture;Award;Communities;Computers;data exchange;design;electronic data;ergonomics;Funding;Image;imaging probe;imaging system;Individual;Institution;Laboratories;Modeling;Morphologic artifacts;Operating System;Outcomes Research;Research;Research Personnel;Research Support;Scanning;Services;Small Animal Imaging Systems;Speed;System;Transducers;Ultrasonography;ultrasound;United States National Institutes of Health;Universities;Visual

PROJECT_TITLE: Small Animal Ultrasound - Vevo F2

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-M (30)]


ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Narrative Cryo-electron microscopy is the prevailing methodology for determining macromolecular structures relevant to human diseases and therapies, but is not readily available to researchers in the Midwest. This application requests support to overcome this limitation by acquiring a Thermo Fisher Scientific Glacios Cryo-Transmission Electron Microscope equipped with Falcon 4i Direct Electron Detector and Selectris Energy Filter as a shared regional facility at the University of Kansas Medical Center. This will allow researchers to obtain broad insight into a range of biological processes to advance their primary mission of improving public health.

PI_NAMEs: FREUDENTHAL, BRET D (contact)

PROJECT_TERMS: Agreement;Awareness;Biological Process;Biological Sciences;Cryoelectron Microscopy;data acquisition;detector;Distant;Electron Microscopy Facility;Eligibility Determination;Funding;Image;improved;Infrastructure;Institution;instrument;Investments;Iowa;Kansas;Location;Medical center;Medical Research;meetings;Midwestern United States;Minor;Molecular Structure;Nebraska;particle;Preparation;programs;Proteins;Research;Research Personnel;Resolution;Resources;Sampling;Scientist;screening;structural biology;Structure;System;Technology;United States National Institutes of Health;Universities;Visualization;Wichita;X-Ray Crystallography

PROJECT_TITLE: Cryo-EM for the Midwest Region

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-B (30)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Narrative This electron detector will be used to see the atoms in proteins, DNA, and RNA in order to understand antimicrobials, transcription, transformation, and viral gene therapy. Moreover, the large field of view of the detector will enable us to image inside cells at the nanoscale. The detector will treble the amount of data collected by our electron microscope while improving resolution.

PI_NAMEs: KAELBER, JASON T (contact)

PROJECT_TERMS: Charge;Complex;Consultations;Core Facility;Coupling;Cryo-electron tomography;Cryoelectron Microscopy;Data;detector;Electron Microscope;Electrons;Equipment;Escherichia coli;Extramural Activities;flexibility;Gene Transduction Agent;Genetic Transcription;imaging facilities;In Situ;insight;Institution;Length;member;Modeling;nanoimaging;Nucleosomes;particle;Polymerase;quantum;Research Personnel;Resolution;Ribosomes;RNA;Series;Services;Signal Transduction;Structure;therapeutic DNA;tomography;Training;Translations;transmission process;Universities

PROJECT_TITLE: Gatan K3 Direct Electron Detector Model 1967


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative This proposal will provide funds for replacing the 7T whole-body MRI human scanner at the Lucas Center for Imaging (LCI) at Stanford University. This scanner is an essential tool for several NIH-funded grants that are currently hampered by the limitations of the existing system and its limited serviceability. The proposed replacement will resolve reliability challenges with the existing legacy system, address service life issues, and decrease patient burden.

PI_NAMEs: BOADA, FERNANDO E (contact)

PROJECT_TERMS: Applications Grants;Clinical;cryostat;design;FDA approved;Generations;imaging facilities;instrumentation;Magnetic Resonance Imaging;manufacture;Manufacturer;Medical;Patient Participation;Research Project Grants;service providers;Services;System;Technology;Universities

PROJECT_TITLE: Ultra-High Field Translational MRI Scanner

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-Z (31)]


ORG_CITY: HOUSTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE  The installation of a CyTOF XT with a Hyperion XTi Imaging System BioSorter in the Cytometry and Cell Sorting Core at Baylor College of Medicine will enhance the capabilities, quality, and throughput of research projects of multiple investigators at Baylor College of Medicine and in surrounding institutes. These investigators focus on immunology, cancerology, cardiovascular disease and neuroscience.

PI_NAMEs: BEETON, CHRISTINE  (contact)

PROJECT_TERMS: Academia;Area;Cardiovascular Diseases;career;Cell Separation;Cells;college;Cytometry;Fostering;Funding;human disease;human model;human subject;imaging platform;Immunology;Individual;Institution;instrument;Medical center;Medicine;Neurosciences;programs;Research;Research Personnel;Resources;Rodent Model;Suspensions;Texas;Tissues;United States National Institutes of Health

PROJECT_TITLE: CyTOF XT with Hyperion XTi platform


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE Technologies that allow real-time monitoring of engineered immune cell distribution within tissues would transform patient treatment and management in oncology. This project will develop stimuli-responsive contrast agents that provide on-demand and long-term deep tissue imaging of cellular immunotherapies via diagnostic ultrasound, using anti-tumor macrophages as an exemplary model. Through this work we will establish a platform technology that can be broadly adopted for in vivo monitoring and modulation of cellular immunotherapies.

PI_NAMEs: KIRIMANJESWARA, GIRISH S;MEDINA, SCOTT HAMMOND (contact);SIMON, JULIANNA ;SLUKVIN, IGOR I.

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Acoustics;Address;Adopted;Adoptive Immunotherapy;Adverse event;Aftercare;Agonist;Antitumor Response;B-Lymphocytes;Behavior;Biodistribution;Biological Assay;Biomedical Engineering;Blood Chemical Analysis;cancer imaging;Cell Line;Cell model;Cell Nucleus;Cell Survival;Cell Therapy;Cells;cellular imaging;Cellular immunotherapy;chimeric antigen receptor;clinically relevant;Communities;Community Clinical Oncology Program;contrast enhanced;Contrast Media;Custom;cytokine;Dendritic Cells;design;Development;Diagnostic;Doppler Ultrasound;Early Diagnosis;empowerment;Emulsions;Engineering;Equilibrium;fighting;Fluorescence;Formulation;Foundations;Frequencies;Goals;high resolution imaging;Histology;Hour;Human;Image;Imaging Device;imaging modality;Imaging technology;Immune;immune imaging;immunoengineering;Immunohistochemistry;Immunologic Adjuvants;Immunologist;immunotoxicity;improved;In Situ;in vivo;in vivo imaging;in vivo Model;in vivo monitoring;Infiltration;innovation;Kinetics;Label;Link;Locales;Lymph;Macrophage;Malignant Neoplasms;Measures;Mediating;Microbubbles;microscopic imaging;migration;Mitochondria;Modeling;Monitor;multidisciplinary;multiplexed imaging;Mus;nanoemulsion;nanoscale;Neuroblastoma;novel;Oncology;particle;patient variability;Patients;Penetration;Peptides;Performance;Phagocytes;Phagocytosis;Pharmaceutical Preparations;phase change;Phenotype;Physiologic pulse;portability;PPAR gamma;Prediction of Response to Therapy;Productivity;Property;Publishing;rational design;real time monitoring;receptor;Research Project Grants;residence;Resolution;response;Route;Safety;safety assessment;Scientist;Signal Transduction;spatiotemporal;Speed;Stains;Stimulus;Structure-Activity Relationship;Surface Tension;Technology;technology development;technology platform;Testing;Therapeutic;therapy outcome;Time;Tissue imaging;tissue phantom;Tissues;tool;Toxic effect;trafficking;Translations;Treatment Efficacy;Treatment Protocols;tumor;tumor behavior;tumor heterogeneity;Ultrasonography;ultrasound;uptake;vaporization;weapons;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Phase Changing Ultrasound Contrast Agents for Deep Tissue Imaging of Cellular Immunotherapies

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: Expanded availability of virtual care encounters in Primary Care provides new opportunities to improve Veterans’ outcomes by aligning encounter modalities with their needs and preferences. Yet, Veterans and their Primary Care physicians (PCPs) lack personalized information about the benefits and costs of different Primary Care modalities that is needed to maximize the value of Primary Care encounters. To address this problem, we will use surveys and interviews to identify what Veterans and PCPs perceive to be the benefits and optimal uses of different Primary Care encounter modalities. We will then supplement our existing system for communicating encounter costs to Veterans and PCPs with new interactive messaging about benefits and optimal uses of different encounter modalities. We will optimize this novel Advancing Decisions about Virtual Service Encounters (ADViSE) intervention through user-centered refinement before evaluating its effects on Veteran-centered outcomes, use of virtual care, and intermediate health outcomes in a randomized trial.

PI_NAMEs: KULLGREN, JEFFREY  (contact)

PROJECT_TERMS: Address;Adverse effects;Advisory Committees;Ambulatory Care;Area;care outcomes;Caring;Chronic Disease;Communication;Complex;copayment;cost;Costs and Benefits;COVID-19 pandemic;data warehouse;Decision Making;Effectiveness;effectiveness/implementation design;Electronics;experience;Face;Health;health administration;health care availability;Health system;Healthcare;Healthcare Systems;Improve Access;improved;Individual;innovation;insight;Intervention;Interview;Managed Care;Measures;Methodology;Modality;Modeling;Needs Assessment;novel;Outcome;Patient Care;patient engagement;patient oriented research;Perception;personalized decision;Physicians;Pilot Projects;pilot test;Policies;pre-pandemic;preference;Primary Care;primary care clinic;Primary Care Physician;primary care practice;primary care visit;primary outcome;randomized trial;Randomized, Controlled Trials;Research;Research Priority;Rural;Sampling;satisfaction;Science;secondary outcome;Services;Strategic Planning;Structure;Surface;Surveys;System;telehealth;Telephone;Testing;Text Messaging;Time;Transportation;Travel;trial design;usability;Veterans;Veterans Health Administration;virtual;virtual healthcare;Visit;Work

STUDY_SECTION_NAME: HSR-3 Healthcare Informatics[HSR3]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: MENANDS

ORG_NAME: WADSWORTH CENTER

PHR: Project narrative. Mycobacterial diseases are a huge burden on global public health. There is a need to better understand the biology of mycobacteria. In this proposal, we will characterize a novel mechanism of chromosomal DNA transfer that has been described in both fast- and slow- growing mycobacteria and, we hypothesize, has played a major role in mycobacterial cell-cell communication and the evolution of mycobacterial pathogens.

PI_NAMEs: DERBYSHIRE, KEITH M;GRAY, TODD  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Acceleration;Automobile Driving;Bacterial Genes;Biochemical;Biological Assay;Biology;C-terminal;Cell Communication;Cells;Chromosomes;Coculture Techniques;Communication;Cysteine;Cytoplasmic Tail;design;Disease;DNA;ELF3 gene;Evolution;experience;extracellular;Gene Expression;Gene Expression Profiling;Gene Pool;Genes;Genetic;Genetic Transcription;Genome;genomic locus;Genomics;Genus Mycobacterium;Goals;homologous recombination;Horizontal Gene Transfer;insight;Mediating;Membrane;Modeling;Molecular;Molecular Genetics;mosaic;Mutagenesis;mutant;mycobacterial;Mycobacterium smegmatis;Mycobacterium tuberculosis;N-terminal;novel;Parents;Partner in relationship;pathogen;Pathway interactions;Play;prevent;Process;protein protein interaction;Proteins;Public Health;response;Role;Sexual Reproduction;Signal Pathway;Specificity;Surface;System;Testing;transcriptome sequencing

PROJECT_TITLE: Characterization of a novel kin recognition system in mycobacteria

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE We are requesting a laser scanning confocal microscope for a microscopy facility that operates at Biosafety level 2 containment, for live cell imaging of samples containing human pathogens and/or potentially infectious biological agents. Located at the Johns Hopkins Bloomberg School of Public Health our projects include work with microbial pathogens that cause Lyme disease, Influenza, Malaria, cryptococcosis, toxoplasmosis and listeriosis disease. The requested instrument would significantly enhance a wide variety of studies that are relevant for the advancement of public health.

PI_NAMEs: HAMACHER-BRADY, ANNE  (contact)

PROJECT_TERMS: Area;Biological Products;Borrelia burgdorferi;Communicable Diseases;Confocal Microscopy;Containment;Cryptococcus neoformans;experimental study;Fluorescence;Fluorescence Resonance Energy Transfer;fluorophore;Funding;human pathogen;Image;imaging facilities;Immunology;Influenza A virus;Institution;instrument;Lasers;Light;Listeria monocytogenes;live cell imaging;Measurement;Medical;Microbiology;Microscope;Microscopy;Molecular;Plasmodium falciparum;Proteins;Public Health Schools;Research;Resolution;Scanning;Speed;Testing;Toxoplasma gondii;Translating;United States National Institutes of Health

PROJECT_TITLE: Confocal microscope for a live cell imaging facility at biosafety level 2


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Feeding is an essential behavior, and the proper regulation of feeding is crucial for maintaining physical and mental well-being. The proposed research aims to investigate the neural circuit mechanisms that integrate external and internal food sensory signals to regulate feeding behavior and feeding-related endocrine function. Compromised function of these mechanisms may contribute to endocrine dysfunction, eating disorders, and body weight changes including obesity, which collectively afflict a large proportion of the United States population.

PI_NAMEs: YAO, ZEPENG  (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Afferent Neurons;Animal Behavior;Animals;Anterior;Architecture;Axon;Behavior;Behavior Control;Behavioral;Biological Models;Body Weight Changes;Brain;Calcium;connectome;Cues;Data;Detection;Digestion;Dilator;Disease;Diuretics;Drosophila genus;Drosophila melanogaster;Eating;Eating Disorders;Electron Microscope;Endocrine;Endocrine system;Esthesia;feeding;Feeding behaviors;fly;Food;food consumption;Foundations;Functional disorder;Functional Imaging;Gastrointestinal tract structure;Goals;Health;Homeostasis;Hormones;Human;Image;imaging approach;Ingestion;insight;Insulin;insulin regulation;Interoception;Intestines;Lateral;Light;Link;Logic;Mammals;Mediating;Metabolic;Metabolism;Midgut;model organism;Motility;Motor;motor control;Motor Neurons;Motor output;Motor Pathways;multimodality;neural;neural circuit;neural model;Neurons;neuroregulation;Nutrient;Obesity;optogenetics;Organ;Oropharyngeal;Output;Pathway interactions;Pharyngeal structure;Physiological;Population;postsynaptic;programs;Publishing;Regulation;Research;Resolution;Sensory;sensory input;sensory integration;Series;Signal Transduction;Stomach;Stream;sugar;Synapses;Taste Perception;Testing;Tongue;United States;Well in self;Work

PROJECT_TITLE: Neural circuits linking food sensory detection to endocrine and feeding control

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ORG_CITY: DAVIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narra�ve The proposal requests funds for a state-of-the-art instrument for a user group across the UC Davis campus to study cellular molecular machines that process DNA, RNA and proteins that regulate and engage the cytoskeleton for myriad cellular functions. The instrument will greatly enhance research capabilities to understand the mechanisms and functional deficits that cause a broad range of metabolic, cardiovascular, neurological, and muscular diseases and cancers.

PI_NAMEs: GOLDMAN, YALE E (contact)

PROJECT_TERMS: Area;Automation;Binding;Binding Proteins;Biochemistry;Biological;Biological Process;Biological Sciences;Biomedical Engineering;Biophysics;California;Cardiovascular Physiology;Cardiovascular system;Cell Communication;Cells;Cellular biology;Color;Computer software;Cytoskeletal Filaments;Data;Dedications;design;Detection;Engineering;Ensure;Enzymes;experimental study;Filament;Fluorescence;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;Fluorescence Spectroscopy;Funding;Health;Healthcare;Institution;instrument;Intuition;Knowledge;Laboratories;laser tweezer;Lasers;Maintenance;medical schools;Microbiology;Microfluidics;Minor;Molecular and Cellular Biology;Molecular Biology;Molecular Genetics;Molecular Motors;nano;Nucleic Acids;operation;optic trap;optic tweezer;optical traps;Pharmacology;Positioning Attribute;programs;Protein Biosynthesis;Request for Proposals;Research;Research Personnel;Resolution;Resources;Running;Sampling;Scanning;Schools;Services;single molecule;System;Technology;Temperature;temporal measurement;Time;tool;Training;United States National Institutes of Health;Universities;user friendly software;user-friendly;Visualization

PROJECT_TITLE: Optical Tweezers with Scanning Confocal Fluorescence Microscopy and Microfluidics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-D (30)]


ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative This application seeks funding for the purchase of an cutting-edge 3D stimulated emission depletion super- resolution microscope system. This state-of-the-art technology will significantly enhance the research efforts of 13 NIH-funded investigators who are addressing vital areas of biomedical research such as neurodegeneration, stroke, aging, vascular disease, pain, diabetes, heart failure, vision, immune-mediated disease, kidney disease, and breast and prostate cancers. Unveiling the molecular mechanisms at the heart of these substantial public health issues necessitates the incorporation of this microscope into our shared resources as a first of its kind at the University of Texas Health Sciences Center at Houston and the Texas Medical Center, making it a crucial and foundational addition to our research capabilities.

PI_NAMEs: MOORE, TRAVIS I (contact)

PROJECT_TERMS: 3-Dimensional;adaptive optics;Address;Area;Biochemical Process;Cancer Center;Charge;Color;Communities;Complex;Contract Services;Core Facility;cost;Dedications;detector;Disease;Equipment;equipment acquisition;Fees;flexibility;Funding;Health;Health Sciences;high resolution imaging;Image;imaging capabilities;imaging system;improved;innovation;Institution;instrument;Lateral;Light;Lighting;Maintenance;Medical center;medical schools;Methodology;Microscope;Microscopy;Molecular;molecular scale;nanoscale;Nanoscopy;operation;Optics;Photobleaching;Refractive Indices;Research;Research Personnel;Resolution;Resource Sharing;Resources;Sampling;Scientist;Signal Transduction;Structure;System;Techniques;Technology;Texas;Tissue Sample;Tissues;tool;Training;ultra high resolution;United States National Institutes of Health;Universities;Variant;Work

PROJECT_TITLE: Super Resolution 3D-STED Microscope for a Core Facility


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: NARRATIVE This project will use advanced genomic, molecular and in vivo studies to compare neural precursor cells throughout the neurogenetic period of the mouse and how the neurons they produce contribute to the mature cortical circuitry.

PI_NAMEs: HAYDAR, TARIK F (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Adult;Apical;autism spectrum disorder;Axon;Brain;calcium indicator;Cell division;Cell Nucleus;Cells;Characteristics;Chromatin;Code;cohort;Complex;Coupled;Data;Data Set;Development;Down's Syndrome;Electrophysiology (science);Event;excitatory neuron;executive function;experimental study;Fragile X Syndrome;Gene Expression;Genetic;Genetic Transcription;Genomics;Growth;Heterogeneity;hippocampal pyramidal neuron;in vivo;innovation;Instruction;Label;Maps;Membrane;Methods;migration;Molecular;Morphology;Motor;multiple omics;Mus;Neocortex;neocortical;nerve stem cell;Nervous System Disorder;Neurodevelopmental Disorder;neurogenesis;neurogenetics;Neuroglia;Neurons;novel;optogenetics;patch clamp;Pattern;Phenotype;postsynaptic;prenatal;presynaptic;Process;Production;programs;Property;Radial;Resolution;response;Scheme;Schizophrenia;segregation;self renewing cell;Sensory;Shapes;single nucleus RNA-sequencing;single-cell RNA sequencing;somatosensory;Somatosensory Cortex;stem;stem cell population;stem cells;Stream;Synapses;System;Testing;Time;tool;Tracer;transcription factor;transcriptomics

PROJECT_TITLE: Direct and Indirect Neurogenesis in the Mammalian Neocortex

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Gene Therapy;Genetics;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Oligonucleotide therapeutics is becoming the third major class of drugs, with fourteen drugs approved. In this proposal, we request funds for equipment to synthesize, purify, and quality control a large number of uniquely modified oligonucleotides in parallel. This equipment will enable the screening and identification of novel therapeutics for a wide range of preclinical research by University of Massachusetts Chan Medical School investigators (and collaborators) and eliminate a significant roadblock in moving oligonucleotide-based therapies toward patients.

PI_NAMEs: KHVOROVA, ANASTASIA  (contact)

PROJECT_TERMS: Acceleration;Amyotrophic Lateral Sclerosis;Basic Science;Central Nervous System;Chemical Structure;Chemicals;Chemistry;clinical development;clinical efficacy;Complex;CRISPR therapeutics;design;Development;Disease;Drug Kinetics;Equipment;Foundations;Funding;Grant;Huntington Disease;Informatics;innovation;instrument;instrumentation;Ions;Kidney;Knowledge;liquid chromatography mass spectrometry;Liver;Lung;Massachusetts;medical schools;Modality;Modification;Muscle;nonalcoholic steatohepatitis;novel;oligonucleotide delivery;Oligonucleotides;Organ;organ transplant rejection;Pattern;Pharmaceutical Preparations;pressure;Privatization;Production;professor;Property;Quality Control;Rare Diseases;Research;Research Personnel;RNA;RNA Interference;Small Interfering RNA;System;Technology;Therapeutic;therapeutic RNA;Time;Translational Research;translational research program;United States National Institutes of Health;Universities

PROJECT_TITLE: High-throughput Oligonucleotide Production System


ADMINISTERING_IC: MH

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative The hippocampus is a brain region that has a key role in learning, memory, and emotions. A group of neurons in the hippocampus, called inhibitory neurons, are needed to keep in check overall activity, and when they are abnormal the hippocampus becomes hyperactive, as occurs in schizophrenia and anxiety. The goal of this study is to investigate how these inhibitory neurons function and are connected in primates, which is necessary to develop therapies for psychiatric diseases.

PI_NAMEs: BARBAS, HELEN  (contact);MEDALLA, MARIA ;ZIKOPOULOS, VASILEIOS

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: Action Potentials;adaptive learning;Affect;Affective;Amygdaloid structure;Animal Model;Anterior;Anxiety;Anxiety Disorders;Axon;Biological Models;biophysical analysis;biophysical properties;Biophysics;Brain region;calbindin;Calcium-Binding Proteins;calretinin;Cells;Cholecystokinin;clinically relevant;Cognition;Cognitive;Communities;Complex;Computer Models;confocal imaging;Confocal Microscopy;Data;Databases;Dendrites;Development;Dimensions;Disease;Disinhibition;effective therapy;Electron Microscopy;Electrophysiology (science);Elements;Emotions;entorhinal cortex;Evolution;Exhibits;falls;Functional disorder;Goals;hippocampal pyramidal neuron;Hippocampus;Human;Hyperactivity;In Vitro;inhibitory neuron;innovation;insight;Learning;Literature;Location;Macaca mulatta;Measures;Mediating;Memory;Mental disorders;Modeling;Mood Disorders;Morphology;multimodality;Mus;nerve supply;neurochemistry;Neurons;neuropeptide Y;Nitric Oxide Synthase;novel;Parvalbumins;Pathway interactions;Peptides;Phylogeny;physiologic model;Physiological;Physiology;Post-Traumatic Stress Disorders;postsynaptic;Predisposition;Prefrontal Cortex;Primates;Process;Property;Publishing;Rattus;Research;Resolution;Rodent;Role;Schizophrenia;Signal Transduction;Site;Somatostatin;Stains;Synapses;System;Testing;Thalamic structure;therapy development;Vasoactive Intestinal Peptide;Work

PROJECT_TITLE: Primate inhibitory neurons in hippocampal CA3-CA1 intrinsic circuits

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHESTNUT HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON COLLEGE

PHR: PROJECT NARRATIVE The proposed study aims to examine whether improvements in the academic or health outcomes of youth following a transition into high quality, mixed-income housing are mediated by shifts in social mobility beliefs, and whether these relations vary with age or racial-ethnic background. Results from this study will clarify a mechanism by which community redevelopment policies create opportunities for academic and health benefits and provide important information about who benefits most from these types of policies.

PI_NAMEs: COLEY, REBEKAH LEVINE (contact);TEIXEIRA, SAMANTHA

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Adolescent Development;Affect;Age;American;Applications Grants;Area;Belief;career development;Categories;caucasian American;Child;Child Development;Childhood;children of color;Cognitive;cognitive development;Communities;community engaged research;Coupled;Data;Data Collection;design;Development;development policy;Discrimination;Economics;Education;Equity;ethnic identity;Ethnic Origin;experience;Exposure to;Family;Future;Goals;grandparent;Health;Health Benefit;health disparity;health economics;Housing;improved;Income;Individual;Inequality;Intervention;Interview;Intuition;life span;Lifting;marginalization;Mediating;Mediation;Mentors;Mentorship;Methods;Modeling;National Institute on Minority Health and Health Disparities;Nationalities;Natural experiment;Outcome;parent grant;peer;Policies;Poverty;Prejudice;Process;programs;Psychologist;Public Housing;Race;racial diversity;Racial Segregation;Research;residence;resilience;response;role model;Schools;Science;Shapes;skills;social;social exclusion;Social Mobility;Social Processes;Social status;structural determinants;success;Testing;Training;willingness;Work;Youth

PROJECT_TITLE: Targeting Health Disparities through Housing Redevelopment: A Natural Experiment of Housing Quality, Stability, and Economic Integration

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Neurosciences;Osteoporosis;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: CHICAGO

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: For this planning grant proposal, we will complete the detailed clinical trial planning necessary to initiate a clinical trial meeting NIH and NIAMS requirement. We will specifically develop detailed clinical, operational and regulatory activities; develop a data safety monitoring plan; identify and vet clinical sites; develop and test training materials, obtain investigational drug; establish data collection, management and data analysis plans; develop a final budget; and submit a U01 application for subsequent funding. The overall goal of the proposed U01 study is to assess the efficacy, safety and durability of sequential treatment with denosumab and zoledronic acid to prevent and maintain bone loss after acute SCI.

PI_NAMEs: SCHNITZER, THOMAS JACK (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Acute;Antibodies;Applications Grants;Biological Markers;bisphosphonate;Blinded;bone;bone loss;bone mass;Bone Resorption;bone strength;Budgets;Case Report Form;Certification;Clinical;clinical decision-making;clinical efficacy;clinical research site;Clinical Trials;Communities;comparative efficacy;Complex;Conduct Clinical Trials;Consent Forms;Contracts;Data;Data Analyses;Data Collection;data integration;data management;data standards;Databases;design;Development;Dose;Double-Blind Method;Dual-Energy X-Ray Absorptiometry;efficacy evaluation;efficacy study;Ensure;Event;experience;Failure;Fracture;fracture risk;Funding;Funding Opportunities;Goals;Grant;Hip region structure;Image;Imaging technology;Individual;inhibitor;Institution;Institutional Review Boards;Intervention;intravenous administration;Intravenous infusion procedures;Investigational Drugs;Knee;Leadership;Lesion;Lower Extremity;Measurement;Measures;Mediation;meetings;member;Mission;Monitor;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Neurologic;operation;Outcome;Pamphlets;Participant;Patients;Persons;Phase;Placebos;Population;Postmenopausal Osteoporosis;Preparation;prevent;Procedures;Protocols documentation;Publishing;Randomized;randomized, clinical trials;recruit;Rehabilitation therapy;Reporting;Research;Research Personnel;Resources;response;Safety;safety study;Sample Size;Sequential Treatment;Serum;Site;skeletal;Spinal cord injury;Statistical Data Interpretation;Testing;Time;timeline;Training;TRANCE protein;trial design;trial planning;United States National Institutes of Health;Weight-Bearing state;X-Ray Computed Tomography;Zoledronic Acid

PROJECT_TITLE: Denosumab and sequential zoledronic acid to prevent bone loss and maintain bone mass after spinal cord injury

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE This project will elucidate the molecular mechanisms underlying negative regulatory effect of STING on antitumor immunity, whereby cGAMP importation into tumor-infiltrating T cell induces STING-mediated cell death. This project will also develop novel strategies for blocking STING-mediated T cell death to improve the outcomes of STING-based cancer immunotherapies.

PI_NAMEs: WU, JIANJUN  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: adaptive immune response;Agonist;anti-tumor immune response;Antigens;Antitumor Response;cancer immunotherapy;cancer infiltrating T cells;CAR T cell therapy;CD8-Positive T-Lymphocytes;Cell Communication;Cell Death;cell type;Cells;Cessation of life;chimeric antigen receptor T cells;Clinical Trials;Complex;Cyclic GMP;Cytosol;Development;DNA Damage;extracellular;Fibroblasts;Gene Activation;Gene Proteins;Genomic Instability;Immune;Immune Evasion;Immune mediated destruction;Immune response;immunogenic;Immunologic Surveillance;Immunosuppression;Immunotherapy;improved;improved outcome;Infiltration;Innate Immune Response;insight;Interferon Type I;Interferons;Malignant Neoplasms;Mediating;Mediator;Modeling;Molecular;Mus;Myeloid Cells;Natural Immunity;Natural Killer Cells;neoplastic cell;novel;novel strategies;Pathway interactions;Play;preclinical study;Predisposition;Production;programs;Research;Resistance;Resistance development;response;Role;Second Messenger Systems;sensor;Signal Transduction;Solid Neoplasm;Stimulator of Interferon Genes;success;T cell response;T cell therapy;T-Lymphocyte;Therapeutic;transmission process;tumor;Tumor Antigens;Tumor Escape;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-Derived;tumor-immune system interactions

PROJECT_TITLE: Deciphering the Roles of STING-Mediated T cell Pyroptosis in Antitumor Immunity

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Cancer;Dementia;Neurodegenerative;Neurosciences

PHR: Project Narrative: The purchase of this instrument will allow a number of research groups at Johns Hopkins University to accelerate the development of novel cancer treatments, improving the outcome for future cancer suffers. It will also be used to better understand basic biological processes involved in human eye development and in stem cell division, which in the longer term will help us understand a range of human eye disorders and more general developmental conditions.

PI_NAMEs: DOBBIE, IAN MICHAEL (contact)

PROJECT_TERMS: Alzheimer's Disease;cancer therapy;Cell Physiology;Clinic;Complex;Concentration measurement;Data;detector;Development;Disease Progression;DNA biosynthesis;Dyes;epigenomics;experimental study;flexibility;imaging facilities;instrument;Kinetics;Lasers;Life;Measurement;Measures;Modality;mRNA delivery;nanoparticle;Nanotubes;Neoplasm Metastasis;Nucleic Acids;Particle Size;Pathway interactions;Photoreceptors;Preparation;Primary Neoplasm;Productivity;Research Project Grants;Sampling;Services;Side;Signal Transduction;Source;Speed;stem cells;Therapeutic;Time;Translations;Tube;Universities;Work

PROJECT_TITLE: CytoFLEX LX flow cytometer


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Brain Disorders;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Frontotemporal Dementia (FTD);Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: About 15-30% of the COVID-19 virus infected population suffer long-term and report ongoing neurological sequelae with diverse neurological manifestations including dementias. Often these dementias result from the abnormal aggregation of tau proteins, called tauopathy, which leads to loss of cognition, as in Alzheimer’s disease; however, the precise molecular mechanism underlying this remains unclear . Herein, we aim to examine the cellular and molecular mechanisms of COVID-induced tauopathy and identify and validate novel lead drug targets toward intervening onset or progression of tauopathy.

PI_NAMEs: BICKFORD, PAULA C;MOHAPATRA, SHYAM S;MOHAPATRA, SUBHRA  (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: 2019-nCoV;Acceleration;Adult;Age;age related;aged;Aging;aging related;Alzheimer's Disease;Alzheimer's disease brain;Attenuated;Behavior;Behavioral;Brain;C57BL/6 Mouse;Clinical;Cognition;Cognitive;Cognitive deficits;cohort;Complement Activation;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 sequelae;cytokine;Data;Dementia;Dendrimers;Development;Drug Targeting;Epidemiology;FK506 binding protein 5;Formulation;frontal lobe;Gene Expression;Genes;Genetic;Genetic Predisposition to Disease;genomic data;Heat-Shock Proteins 90;Histologic;IFITM1 gene;immune activation;Immunologics;Impaired cognition;Individual;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;innate immune mechanisms;innovation;interdisciplinary approach;Interferons;Knowledge;Lead;Left;Link;Long COVID;Measures;Modeling;Molecular;Molecular Target;mouse model;Mus;Natural Immunity;Nerve Degeneration;Neuroimmune;neuroinflammation;Neurologic;Neurologic Symptoms;neuropathology;neurotoxic;neurotropic;Neurotropism;novel;Orthologous Gene;Pathology;Patients;Plasma;Plasmids;Population;Post-Acute Sequelae of SARS-CoV-2 Infection;Process;protein misfolding;Proteins;Regulation;Reporting;Risk;Role;SARS-CoV-2 infection;small hairpin RNA;symptomatology;Symptoms;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;Tissues;transcriptomic profiling;Transgenic Mice;Virus;Virus Diseases;Work

PROJECT_TITLE: Molecular Targets Modulating Neuro COVID Sequelae Linked to Tauopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-T (57)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative  The high-resolution mass spectrometer requested (Thermo IQ-X) in this proposal will be housed in the Translational Biomarker Core (TBC), a unique resource in the Center for Excellence in Environmental Toxicology (CEET) at the University of Pennsylvania. It will promote the advancement of biomedical research by allowing investigators to perform discovery experiments that will lead to the investigation of novel pathways in basic, clinical and translational science.

PI_NAMEs: MESAROS, A. CLEMENTINA  (contact)

PROJECT_TERMS: arm;base;Bioinformatics;Biological Assay;Biological Markers;Calibration;Chronic Disease;Collaborations;Complement;Computer software;Coupled;COVID-19;Data;Data Analyses;Dedications;Diabetes Mellitus;experimental study;Fee-for-Service Plans;Funding;Grant;High Pressure Liquid Chromatography;Immunology;Inflammation;instrument;instrumentation;interest;Isotopes;Laboratories;large datasets;Libraries;lipidomics;Lipids;Liquid Chromatography;Maintenance;Malignant Neoplasms;mass spectrometer;Mass Spectrum Analysis;medical schools;metabolomics;method development;Methodology;Mission;nano;novel;Pediatric Hospitals;Pennsylvania;Philadelphia;Preparation;Proteomics;Research Personnel;Research Project Grants;Resolution;Running;Sampling;small molecule;System;Technology;Time;Toxicology;Training;Training and Education;translational medicine;translational therapeutics;ultra high pressure;ultra high resolution;United States National Institutes of Health;Universities

PROJECT_TITLE: Thermo IQ-X high-resolution mass spectrometer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-T (30)]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: LITTLE ROCK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: NARRATIVE Replacing the Illumina NovaSeq 6000 Next Generation Sequencing (NGS) system with the new NovaSeq X Plus will improve services provided by the UAMS Genomics Core Facility to all users. The University of Arkansas for Medical Sciences (UAMS) Genomics Core Facility is an important resource for faculty and students in Arkansas who are involved with cutting-edge biomedical research. State-of-the-art genomic scientific instrumentation is essential to facilitate novel research for faculty and students in Arkansas and, help achieve the goal of obtaining NCI Cancer Center Designation by UAMS.

PI_NAMEs: JOHANN, DONALD  (contact)

PROJECT_TERMS: Arkansas;Award;bioinformatics pipeline;Biological;Biological Assay;Cancer Center;cancer therapy;Chemistry;college;Consultations;Core Facility;cost;Data Analyses;Development;expectation;Experimental Designs;experimental study;Faculty;Fostering;Funding;genome sciences;Genomics;Goals;Grant;Health;Human;Immune response;improved;Institution;instrument;instrumentation;Length;liquid biopsy;Malignant Neoplasms;Medical;Medicine;meetings;member;Mission;Molecular Profiling;Musculoskeletal Diseases;next generation;next generation sequencing;novel;Pediatric Research;Persons;Preparation;Price;Reagent;Refrigeration;Research;Research Activity;Research Personnel;Resources;Running;Sampling;Science;Services;Specificity;Students;success;System;Technology;Temperature;Time;undergraduate student;United States National Institutes of Health;Universities;Validation

PROJECT_TITLE: NovaSeq X Plus, Advanced Next Generation Sequencer


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Dental, Oral, and Craniofacial Disease

ORG_CITY: Fort Lauderdale-Davie

ORG_NAME: NOVA SOUTHEASTERN UNIVERSITY

PHR: Our existing micro-CT in the core facility of Center for Collaborative Research (CCR) became dysfunctional which placed the NIH-funded researchers and other users of micro-CT in a dire situation. To this end, the S10 large grant mechanism is the only way for NSU researchers to obtain a new micro-CT (Bruker SkyScan 1276). Based on the following facts and condition available for this S10 application; 1) excellent panel of 7 major and 7 minor users who have research project that require micro-CT, 2) absence of high resolution in vivo micro-CT in any academic institution in South Florida, 3) experienced support staffs designated for the operation of the new micro-CT, 4) the efficient management and maintenance of all shared equipment in the CCR by Dr. Robin Krueger, NSU Director of Scientific Facilities, 5) the technical expertise of micro-CT operation available from Dr. Heidari, designated operator, and other major users who have experience in operating current SkyScan 1176 micro-CT, 6) well balanced oversight committee composed of internal and external researchers who are users and non-users, as well as 7) outstanding institutional support for the infrastructure and maintenance service, we are confident that the proposed acquisition of SkyScan 1276 micro-CT will strongly benefit the research and training at NSU and neighboring institutions in line with the mission of NIH.

PI_NAMEs: HAN, XIAOZHE  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;aging related;Agreement;Antibiotic Resistance;Award;Biology;Blood Vessels;bone;bone imaging;Bone Regeneration;Cancer Biology;Collaborations;college;Computer software;Computers;Core Facility;craniofacial;Data Analyses;Dental;Disease;Ensure;Equipment;Florida;Funding;Goals;Health Professional;HIV;Institution;instrument;Investments;Laboratories;Life;Lytic;Maintenance;Manufacturer;Medicine;member;microCT;mineralization;Minor;Mission;oceanic research;Oceanography;operation;Oral;Osteopathic Medicine;Pharmacy facility;Price;Production;programs;reconstruction;recruit;Research;research faculty;Research Personnel;Services;skeletal;Solid;Structure;System;Technology;Three-dimensional analysis;Time;Tissues;Tooth structure;Training;United States National Institutes of Health;Universities

PROJECT_TITLE: SkyScan 1276 uCT for multi-user biomedical studies


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Lightsheet microscopy is a technology that provides the ability to rapidly acquire millimeter-scale fluorescence image volumes at subcellular resolution, providing a practical solution to the challenge of fluorescence microscopy of large optically-cleared tissue samples, such as the entire organs of animal models. This is a proposal for funding to purchase an Alpenglow 3Di Open-Top-Lightsheet microscope system that will enable Indiana University investigators to conduct exciting and entirely new studies that will enhance their NIH-funded research and advance their goals to address serious issues in human health.

PI_NAMEs: DUNN, KENNETH W (contact)

PROJECT_TERMS: Address;Biological;Core Facility;design;Diabetes Mellitus;Equipment;fluorescence imaging;Fluorescence Microscopy;Funding;Future;Goals;Health;Hematology;high resolution imaging;Human;Hybrids;Image;Indiana;Kidney;Light;medical schools;Medicine;Microscope;microscopic imaging;Microscopy;millimeter;molecular imaging;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;novel;Optics;Productivity;Research;Research Personnel;Resolution;Sampling;Slide;Speed;System;Technology;Tissue Sample;United States National Institutes of Health;Universities

PROJECT_TITLE: Lightsheet microscope system for the Indiana Center for Biological Microscopy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (30)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Over the last three decades, hundreds of genes have been associated with inherited retinal dystrophy highlighting the heterogeneous basis of these blinding diseases. Here, we identify a shared photoreceptor nuclear migration pathology caused by mutations in either ARL3 or RP2 genes linked to autosomal dominant and X-linked retinitis pigmentosa, respectively. Using an RP2 mouse model we will investigate how misplaced nuclei impact photoreceptor function and disease progression, examine gene-independent therapies, and elucidate the signal guiding nuclear migration during retinal development; so that we, as a community, are better positioned to develop new therapeutic strategies.

PI_NAMEs: PEARRING, JILLIAN NYDAM (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Affect;Apical;ARL3 gene;autosome;Biological;Blindness;Brain;Cell Nucleus;Cells;Chelation Therapy;Cilia;Communities;Cyclic AMP;Data;Defect;Development;Disease;Disease Progression;Event;Functional disorder;Gene Delivery;Gene Mutation;gene therapy;Genes;Genetic;Goals;GTPase-Activating Proteins;Guanosine Triphosphate;Health;Hereditary Disease;Histologic;Human;Hydrolysis;Imaging Techniques;Inherited;Inner Nuclear Layer;insight;Knowledge;Label;Link;Lipids;live cell imaging;Measures;Methods;migration;Molecular Chaperones;Molecular Diagnosis;Monitor;Monomeric GTP-Binding Proteins;mouse model;Mus;Mutation;Natural History;Neurons;novel;novel therapeutic intervention;Nuclear;Nuclear Translocation;overexpression;Pathogenicity;Pathology;Pathway interactions;Patients;Phenotype;Photophobia;Photoreceptors;Positioning Attribute;postmitotic;postnatal;prevent;Process;Proteins;Proteome;Publications;Rapid screening;response;Retina;retina outer nuclear layer;Retinal Degeneration;Retinal Diseases;Retinal Dystrophy;Retinal Photoreceptors;retinal rods;Retinitis Pigmentosa;Rod;Signal Transduction;Synapses;synaptogenesis;Techniques;Therapeutic;therapeutic target;Vision;Visual

PROJECT_TITLE: Investigating Photoreceptor Nuclear Migration Defects Caused by Loss of Retinitis Pigmentosa 2.

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Nutrition

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative The indirect calorimetry system, Promethion-Core, is one of the best products in the market that has been used by a long list of NIH-funded research institutes. It simultaneously quantifies multiple parameters including oxygen consumption, carbon dioxide production, energy expenditure, substrate utilization, food and water intake, and spontaneous activity. Those data are crucial for research groups that study a wide range of diseases related to metabolic disorders, such as diabetes, obesity and cardiovascular diseases, cancer, and aging.

PI_NAMEs: LI, YING  (contact)

PROJECT_TERMS: barometric pressure;Behavior;Behavioral;Body Weight;Carbon Dioxide;Eating;energy balance;Energy Metabolism;Ensure;Environment;Funding;Home;Humidity;Indirect Calorimetry;Individual;insight;instrument;Light;Marketing;Metabolic;metabolic phenotype;Molecular;Oxygen Consumption;Pathway interactions;Production;Regulation;Research;Research Personnel;Sampling;sound;System;Temperature;Time;United States National Institutes of Health;Universities;Utah;Water consumption

PROJECT_TITLE: Promethion metabolic phenotyping system

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-M (30)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Genetics;Human Genome

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative Rapid advancements in genomics have resulted in remarkable achievements, but they have also exposed inequities in supporting entry-level educators, particularly at community colleges that serve under- represented students. To bridge this divide, we propose the creation of the Genomic Education Modules (GEMs), grounded in real genomic data research, and designed to fill needs within existing courses, that focus on strengthening participants’ hands-on skills with data. Our strategy also includes training through a yearly in-person Learn-a-thon, comprehensive support, and scalability that leverages our experience bringing online education to millions of learners, ensuring flexibility and adaptability for a broad network of educators.

PI_NAMEs: HOFFMAN, AVA MARIE (contact)

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Accountability;Achievement;Active Learning;Address;Adoption;Chalk;Coffee;Collaborations;Communication;Communications Media;community college;community engagement;Community Networks;Critical Thinking;curriculum development;Data;Data Science;Data Set;design;Development;diversity and equity;E-learning;Education;Educational Curriculum;Educational process of instructing;effectiveness evaluation;empowerment;Ensure;Equity;Ethics;Evaluation;Event;experience;Face;Faculty;faculty community;faculty support;Feedback;flexibility;Focus Groups;Fostering;Funding;Future;genomic data;Genomics;Goals;Healthcare;Hispanic-serving Institution;Historically Black Colleges and Universities;Hour;improved;Inequity;innovation;innovative technologies;Institution;instructor;Knowledge;Laboratories;Lead;Learning;learning materials;Learning Module;massive open online courses;meetings;minority student;Needs Assessment;online course;online resource;open source;Participant;peer;Persons;Play;Population;programs;Publishing;Relationship-Building;Research;Resources;Role;Science;Scientist;Site;skills;Societies;Students;success;Suggestion;support network;Support System;Surveys;Teacher Professional Development;Teaching Method;technical college;Technology;Thinking;Time;Training;Training Activity;tribal college;Trust;Underrepresented Students;United States;Visit;web site;Work

PROJECT_TITLE: Faceting GEMs (Genomics Education Modules) for the Entry-level Workforce

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-M (J2)]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Ultra-high magnetic field strength MRI scanners offer significant benefits for advanced imaging of small animal disease models supporting the extraordinary community of internationally respected scientists at Washington University. This application seeks funding in partial support of the purchase of an ultra-high field, 15.2-Tesla, small-animal MRI scanner to replace an aging system with unsustainable liquid helium usage.

PI_NAMEs: QUIRK, JAMES DENNIS (contact)

PROJECT_TERMS: Anatomy;Animals;Applications Grants;Biomedical Research;blood oxygen level dependent;Cell Nucleus;Communities;Computer software;Consumption;cost;Department chair;Engineering;experimental study;Functional Magnetic Resonance Imaging;Funding;Future;Helium;Hour;Hydrogen;Image;imaging program;improved;Institution;instrumentation;Iron;Libraries;Liquid substance;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Marketing;medical schools;Modernization;nanoparticle;Noise;pandemic disease;Performance;Physiologic pulse;pre-clinical;preclinical imaging;Predisposition;programs;Pump;Radiology Specialty;Research;Resolution;Resources;RF coil;Schools;Services;Signal Transduction;System;Technology;Ultrafine;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: Replacement of a pumped 11.74-T Small-Animal MRI Scanner with a 15.2-T System

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-Z (31)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;HIV/AIDS;Neurosciences;Wound Healing and Care

ORG_CITY: KANSAS CITY

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

PHR: Narrative Following the replacement of the failed magnet, we will have a fully functional animal MRI scanner that will provide state-of-the-art pre-clinical imaging for biomedical scientists from Kansas City and the surrounding region who use animal models of normal function and disease to develop new cures. Once commissioned, our investigators will continue a considerable body of NIH-funded work. This scanner will provide a user-friendly interface for programming and an extensive library of well-established acquisition protocols for scientists and an outstanding training environment for graduate students, post-doctoral fellows, and faculty scientists.

PI_NAMEs: BOSSMANN, STEFAN H (contact)

PROJECT_TERMS: Adopted;Alzheimer's Disease;Animals;biomedical imaging;Cancer Center;Clinical;Clinical Sciences;Cognitive;Collaborations;Complex;cost;data acquisition;Data Analyses;design;Developmental Biology;Electronics;Equipment;frontier;Funding;Furuncles;graduate student;graphical user interface;Image;imaging facilities;imaging scientist;Institution;Intellectual and Developmental Disabilities Research Centers;Intuition;Kansas;Kidney Diseases;Liver diseases;Lung Diseases;Magnetic Resonance Imaging;Medical center;Metabolism;Methodology;Midwestern United States;Minor;Nerve Degeneration;Nervous System Disorder;Neurobiology;Obesity;Pain;Performance;Polycystic Kidney Diseases;Postdoctoral Fellow;protocol development;Request for Proposals;Research;Research Activity;Research Design;Research Personnel;Research Support;Resources;Support System;System;Technology;Training;Translational Research;Translations;United States National Institutes of Health;Universities;user-friendly

PROJECT_TITLE: Zero Cryogen Boiloff Technology Magnet: A Regional Animal MRI Resource


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative This application requests funds to purchase an automated radiosynthesis platform to prepare multiple carbon- 11 radiopharmaceuticals for positron emission tomography (PET) imaging. Compounds, or ‘radiotracers’, prepared using this equipment will be used to non-invasively detect disease and measure response to therapies in human beings and preclinical models.

PI_NAMEs: PETERSON, TODD E (contact)

PROJECT_TERMS: Amyloid;Amyloid beta-Protein;Carbon;Cardiovascular Diseases;Clinical Research;Core Facility;Funding;Future;Human;imaging science;imaging system;Malignant Neoplasms;manufacturing capabilities;Molecular;Nervous System Disorder;novel;novel therapeutic intervention;PET/CT scan;Positron-Emission Tomography;pre-clinical;pre-clinical research;Production;Radiochemistry;radiotracer;Request for Applications;Research;Research Personnel;Running;System;tau Proteins;Tracer;United States National Institutes of Health;Universities

PROJECT_TITLE: Automated Multi-run Carbon-11 Radiosynthesis System


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative This study will apply lessons learned from past Mixed Toxin Exposures (MTE) to assess the short term (~2-3 years) health impact of MTE following the East Palestine, Ohio (EP) train derailment and associated toxin release – and to learn lessons from this that can be applied to mitigate impact when the next MTE event strikes. This study assesses both EP toxin (EPT)-specific and previously MTE-related health outcomes to provide the broadest possible contribution to knowledge. It takes understanding (that we have pioneered) of toxicity mechanisms that traverse specific chemical class, to inform assessment of protection and vulnerability factors that may help this study to not only improve the lives of those affected in this MTE event but potentially the lives of others when future such incidents arise.

PI_NAMEs: GOLOMB, BEATRICE A (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Address;Affect;Age;archive data;Archives;Area;Award;Baseline Surveys;biobank;burn pit;Cardiovascular system;Chemicals;Chronic;Clinical;clinical effect;Coenzyme Q10;cohort;community partnership;comparative;Consent;Cost efficiency;Data;data archive;Development;Estradiol;Event;Exposure to;Fingers;follow-up;Foundations;Funding;Future;Glycosylated hemoglobin A;Grant;Health;Hepatic;Hypertension;Impairment;improved;improved outcome;indexing;Individual;Inflammation;Institutional Review Boards;interest;Interview;Investigation;Kidney;Knowledge;Laboratories;Learning;Lipids;Longitudinal cohort;Longitudinal Surveys;Measures;Mitochondria;Modification;Ohio;Outcome;Outcome Assessment;Oxidative Stress;oxidized low density lipoprotein;Persian Gulf Syndrome;Persons;Phase;Pilot Projects;pilot test;Plasma;Population;Prevention;protective factors;Public Health;randomized trial;recruit;Reporting;Research;Research Personnel;Resources;respiratory;sample archive;Secure;Serum;Severities;sex;Sleep Apnea Syndromes;Source;Speed;Spottings;Subgroup;success;Surveys;Symptoms;Testing;Toxic effect;Toxin;Training;Transcend;United States National Institutes of Health;Update;Venous blood sampling;Work

PROJECT_TITLE: Uncovering the Short-Term Public Health Impact of Toxin Release in East Palestine, Ohio: Outcomes and Effect Modifiers

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 ARL-W (21)]


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Positron Emission Tomography (PET) /Computed Tomography (PET/CT) is critical for the development of new molecularly targeted radiopharmaceuticals for imaging and theranostic treatment of cancer. The role of the University of Wisconsin Carbone Cancer Center Small Animal Imaging and Radiotherapy Facility (SAIRF) expanded recently in response to a large influx of grants utilizing targeted radionuclide therapy to enhance tumor response to immunotherapy. This proposal is intended to purchase a state-of-the-art, high resolution microPET/CT scanner, replacing our existing and soon-to-be unsupported Siemens Inveon microPET/CT which is currently the only microPET/CT scanner in Wisconsin.

PI_NAMEs: WEICHERT, JAMEY P (contact)

PROJECT_TERMS: animal imaging;Animals;Applications Grants;Biological;Cancer Biology;Cancer Center;cancer therapy;Communities;Data;Development;Disease;Dose;dosimetry;Equipment;External Beam Radiation Therapy;Faculty;Fee-for-Service Plans;Fostering;Funding;Human Resources;Image;Immunologic Memory;Immunotherapy;improved;Institution;instrument;Laboratories;Life;Malignant Neoplasms;medical schools;member;microPET/CT;Minor;Multimodal Imaging;PET/CT scan;Positron-Emission Tomography;Price;Productivity;programs;Public Health;Radiation;Radiation therapy;Radionuclide therapy;Research;Research Personnel;Research Project Grants;Resolution;Resource Sharing;Resources;response;S10 grant;Services;System;Technical Expertise;Treatment Efficacy;tumor microenvironment;United States National Institutes of Health;Universities;Wisconsin;X-Ray Computed Tomography

PROJECT_TITLE: UW PET/CT Acquisition


NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Interleukin-6 (IL-6), a pleiotropic cytokine that functions through “cis-“ and “trans-“ signaling, plays an important role in the pathogenesis of diabetic retinopathy (DR). We hypothesize that disruption of the IL-6 cis-trans balance within Müller glial cells (MGCs) contributes to the altered levels of vascular endothelial growth factor A & B (VEGFA, VEGFB) seen in DR, and that the contribution of IL-6 to oxidative stress and blood-retinal barrier breakdown may be mediated by a VEGF-dependent mechanism. Results from our proposed studies have the potential to provide a new therapeutic approach to mitigate the retinal neurovascular pathology associated with diabetes by restoring the IL-6 cis-trans balance in the retina.

PI_NAMEs: SHARMA, SHRUTI  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Adult;Affect;Binding;Bipolar Neuron;Blindness;Blood Vessels;Blood-Retinal Barrier;Cell Communication;cell type;combat;cytokine;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Retinopathy;Endothelial Cells;Endothelium;Equilibrium;experimental study;Feedback;Functional disorder;glycemic control;Homeostasis;IL-6 inhibitor;in vivo;Inflammation;Inflammatory;Injury;Inner Nuclear Layer;interest;Interleukin 6 Receptor;Interleukin-6;Intraperitoneal Injections;Link;Measures;Mediating;Membrane;Modality;Muller's cell;Mus;Neuroglia;neuroprotection;neurovascular;novel;novel therapeutic intervention;novel therapeutics;oxidative damage;Oxidative Stress;Oxidative Stress Induction;Pathogenesis;Pathogenicity;Pathology;patient subsets;Patients;Pharmaceutical Preparations;Physiologic Neovascularization;Play;prevent;Production;Proteins;regenerative;repaired;Retina;Role;Signal Transduction;Source;Testing;Therapeutic;Thinness;treatment optimization;Treatment outcome;Vascular Endothelial Growth Factor B;Vascular Endothelial Growth Factors;VEGFA gene;Vision

PROJECT_TITLE: Targeting Interleukin-6 cis-trans balance in Müller cell dysfunction

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SHREVEPORT

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: Project Narrative Macro-autophagy and mitophagy are crucial for maintaining cellular homeostasis by efficiently removing unwanted cellular proteins and damaged mitochondria. This proposal will investigate the beneficial role and mechanisms of Sigmar1-mediated activation of macro-autophagy and mitophagy in protecting HF. In addition, this research aims to delineate Sigmar1’s novel signaling pathways and molecular mechanisms to restore cardiac functions to rescue HF.

PI_NAMEs: BHUIYAN, MD. SHENUARIN  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Ablation;Agonist;antagonist;Autophagocytosis;Biochemical;Bioinformatics;Cardiac;Cardiac Myocytes;cardioprotection;Cells;Complex;conditional knockout;Correlative Study;Data;Dependovirus;Development;Down-Regulation;Elongation Factor;Fibrosis;Functional disorder;gain of function;Gene Delivery;Gene Modified;Genetic;genetic approach;Heart;Heart failure;heart function;Heart Injuries;Homeostasis;Hypertrophy;Impairment;In Vitro;in vivo;in vivo Model;Injury;interdisciplinary approach;Ischemia;knock-down;Knockout Mice;Laboratories;Ligands;Light;Literature;loss of function;MAP1 Microtubule-Associated Protein;Mediating;Mitochondria;Molecular;mouse model;Mus;Myocardial dysfunction;Myocardial Ischemia;novel;Null Lymphocytes;Organelles;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;pharmacologic;Physiological;pleiotropism;pressure;prevent;Process;protective effect;Protein Family;Proteins;Proteomics;Publishing;receptor;Receptor Activation;receptor function;Receptor-Interacting Protein;Regulation;Reporter;Reporting;Research;response;Role;Satellite Viruses;Serotyping;sigma-1 receptor;Signal Pathway;stem;Stress;Structure;Testing;Therapeutic;Transgenic Mice;Translations;Up-Regulation

PROJECT_TITLE: Novel mitophagy regulatory mechanism in heart failure

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it investigates whether a novel artificial intelligence– based method, which allows primary care providers to screen patients for vision-threatening diabetic eye disease in the primary care clinic, improves screening and follow-up care rates across race/ethnicity groups and reduces racial/ethnic disparities in screening. If this screening strategy is effective, it could replace our current screening system, in which primary care providers must refer patients with diabetes to an eye care provider for a dilated eye exam, a separate appointment that less than one-third of at-risk patients attend. Because higher screening and follow-up care rates would prevent unnecessary vision loss, the proposed research is relevant to the National Eye Institute’s Strategic Plan and Notice of Special Interest, which emphasize the importance of eliminating vision loss and improving quality of life through public health and disparities research.

PI_NAMEs: CHANNA, ROOMASA  (contact)

PROGRAM_OFFICER_NAME: SHOAIBI, AZADEH

PROJECT_TERMS: Address;Adoption;Adult;Affect;aged;Algorithms;Appointment;Artificial Intelligence;artificial intelligence algorithm;Blindness;care providers;Caring;Clinic;Consolidated Framework for Implementation Research;cost;Country;design;Diabetes Mellitus;diabetic;Diagnosis;Diagnostic;Disparity;disparity reduction;Education;effectiveness evaluation;Eligibility Determination;Ensure;Equity;ethnic disparity;ethnic minority;Ethnic Origin;Ethnic Population;Evidence based program;Eye;Eye diseases;FDA approved;Federally Qualified Health Center;follow-up;Future;health equity;Healthcare;Image;implementation barriers;implementation facilitators;Improve Access;improved;Individual;innovation;interest;Intervention;Interview;Knowledge;Leadership;markov model;Medicaid;medically underserved;Methods;multidisciplinary;National Eye Institute;neighborhood disadvantage;novel;ophthalmic examination;Outcome;Participant;Patient Care;Patient Education;patient screening;Patients;Perception;Performance;Persons;point of care;Population;prevent;Primary Care;primary care clinic;primary care provider;primary care setting;primary care visit;programs;Protocols documentation;Provider;Public Health;Qualifying;Quality of life;Race;racial disparity;racial minority;racial population;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Research;Risk;Schedule;screening;screening program;socioeconomic disadvantage;Strategic Planning;Structure;System;Technology;Testing;Time;tool;Transportation;treatment as usual;treatment program;underserved community;Vision;Visit;Work

PROJECT_TITLE: Leveraging Artificial Intelligence to Prevent Vision Loss from Diabetes Among Socioeconomically Disadvantaged Communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


NIH_SPENDING_CATS: Diabetes

PHR: Project Narrative Primary cilia are signaling hubs on the cell surface with demonstrated roles in promoting islet cell coordination and function in diabetes, however the signaling pathways by which cilia mediate islet cell communication have not been elucidated. This proposal aims to identify the intra-islet paracrine regulatory mechanisms by which primary cilia modulate islet cell activity via the major α/β-cell secretory products. Completion of this study will facilitate the identification of new therapeutic targets for preserving islet function and improving glucose control in diabetes.

PI_NAMEs: HUGHES, JING WANG (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Adenylate Cyclase;Alpha Cell;Anabolism;autocrine;Autocrine Communication;base;Beta Cell;Biochemical;Blood Glucose;blood glucose regulation;Cell Communication;Cell Physiology;Cell secretion;Cell surface;Cells;Characteristics;Cilia;ciliopathy;Communication;Coupling;Cues;Cyclic AMP;Data;Dependence;Development;Diabetes Mellitus;Diffusion;Endocrine;Equilibrium;Etiology;Eukaryotic Cell;experimental study;extracellular;Failure;Family;Feedback;G-Protein-Coupled Receptors;Gene Deletion;Glucagon;glucagon-like peptide 1;Glucose;Glucose Intolerance;Growth Factor;Health;Homeostasis;Hormonal;hormonal signals;hormone regulation;Hormone secretion;Hormones;Human;human model;Image;Impairment;improved;Insulin;insulin secretion;interest;Investigation;Ion Channel;islet;Islet Cell;Islets of Langerhans;Knock-out;Lead;Lipids;Maintenance;Mammalian Cell;Mediating;Membrane;Metabolic;Molecular;mouse model;Mus;Neurotransmitters;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Obesity;Organelles;Outcome;paracrine;Paracrine Communication;Peptides;Phenotype;Physiological;Play;Population;preservation;prevent;Process;Production;proglucagon;Protein Tyrosine Kinase;Proteins;Publishing;receptor;receptor expression;Regulation;response;Rodent Model;Role;Route;Secretory Cell;Sensory;Serotonin;Signal Pathway;Signal Transduction;Signaling Protein;Somatostatin Receptor;Structure of beta Cell of islet;Surface;Syndrome;Testing;therapeutic target;transmission process;Zebrafish

PROJECT_TITLE: Paracrine regulation of islet cell function by primary cilia

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Biotechnology;Pediatric

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: PROJECT NARRATIVE This proposal seeks support to acquire a state-of-the-art fluorescence activated cell sorter (FACS, Becton Dickenson FACS Melody instrument) for use by Stanley Manne Children’s Research Institute (SMCRI) investigators at the Ann & Robert H. Lurie Children’s Hospital in Chicago. FACS analysis is critically important for biomedical research in diverse disciplines related to human health, as it permits the collection of specific cell types from heterogeneous suspensions of cells, typically obtained through the enzymatic digestion of intact tissues, organs or tumors. SMCRI investigators currently must compete for access to heavily subscribed FACS instruments at neighboring institutions, so the acquisition of this instrument will accelerate research productivity of its investigators who study diverse biomedical processes that are central to human health and disease.

PI_NAMEs: SCHUMACKER, PAUL T (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Acceleration;Advisory Committees;Award;Blood;Businesses;Calibration;Cancer Biology;cell type;Cells;Charge;Chicago;Child;Contract Services;Core Facility;cost;Developmental Biology;Digestion;Discipline;Disputes;Equipment;Faculty;Fees and Charges;fluorescence activated cell sorter device;Fluorescent Antibody Technique;Funding;Genetic;Heart;Hour;Immunology;Institution;instrument;investigator training;Label;laboratory experience;Lung;Maintenance;member;Minor;operation;Organ;Pediatric Hospitals;Productivity;Proteins;Reporting;Request for Proposals;Research Institute;Research Personnel;response;Secure;Site;Sorting;Suspensions;System;Technology;Time;Tissues;Training;United States National Institutes of Health

PROJECT_TITLE: Fluorescence Activated Cell Sorter

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-D (30)]


NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE This project aims to enhance our understanding of a type of cell called a mural cell, which plays a crucial role in the health and function of our blood vessels. We plan to utilize cutting-edge techniques to manipulate stem cells, turning them into mural cells, which we will then study in a lab-created miniature organ model. This research will expand our knowledge of blood vessel development and function and pave the way for potential new vascular disease treatments and regenerative medicine advancements.

PI_NAMEs: MELERO-MARTIN, JUAN M (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Affect;Blood flow;blood vessel development;Blood Vessels;Calcium;Cell Differentiation process;Cell Lineage;Cell Maturation;Cell Reprogramming;cell type;Cells;Characteristics;Chemicals;Chromatin;Data;Development;Engraftment;Ensure;Epigenetic Process;Extracellular Matrix;Fibroblasts;Generations;Genes;Genetic Transcription;Goals;Health;Heterogeneity;Homeobox;human induced pluripotent stem cells;in vivo;induced pluripotent stem cell;innovation;Investigation;Ischemia;Knowledge;Limb structure;Methods;Modeling;Modification;Molecular;Molecular Profiling;Mus;Natural regeneration;neovascularization;novel;novel therapeutic intervention;Nucleic Acid Regulatory Sequences;Organ Model;Organoids;Patients;Pericytes;Play;Process;Production;progenitor;Property;regenerative cell;Regenerative Medicine;repaired;Research;restoration;revascularization;Role;single-cell RNA sequencing;Smooth Muscle Myocytes;Source;spatiotemporal;Specific qualifier value;stem cells;Techniques;Testing;Therapeutic;therapeutically effective;tissue repair;Tissues;Traction;transcription factor;Transcriptional Regulation;transcriptomics;Transplantation;vascular abnormality;Vascular Diseases;Vascular Endothelial Cell;Vascularization

PROJECT_TITLE: A Novel Transcription Factor-Driven Approach for Mural Progenitor Cells Generation

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ORG_CITY: IRVINE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative  Funds are requested for a mass spectrometer instrument system optimized for imaging of biomolecules by ion mass. Imaging mass spectrometry (IMS) provides a unique analytical tool to preserve spatial information in the analysis of complex biomedical samples. The IMS instrument will be used to address research questions in metabolomics, neurodegenerative diseases, cancer biology, pharmacogenetics, biomedical engineering of artificial tissues and understanding fundamental organismal development.

PI_NAMEs: GRUN, FELIX  (contact)

PROGRAM_OFFICER_NAME: CHEN, YONG

PROJECT_TERMS: Age;Alzheimer's disease model;Biological Sciences;Cartilage;Charge;Core Facility;design;Detection;Doctor of Philosophy;Dry Eye Syndromes;Engineering;environmental change;experience;Extracellular Matrix;Functional disorder;Funding;Goals;high dimensionality;Image;Institution;instrument;Interdisciplinary Study;Ions;Lasers;lens;Lipids;Maintenance;mass spectrometer;mass spectrometric imaging;Mass Spectrum Analysis;Medicine;member;Metabolic;metabolomics;Molecular;neuropathology;Peptides;Pharmacologic Substance;Pharmacy facility;Phenotype;physical science;Plants;programs;protein distribution;Proteins;Proteomics;Qualifying;Research;Research Personnel;Resolution;Resources;Running;Sampling;Scanning;Schools;Science;Scientist;Services;small molecule;Specialist;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Speed;System;Techniques;Tissues;Training;tumor heterogeneity;United States National Institutes of Health;user-friendly;Walking

PROJECT_TITLE: A MALDI-QTOF for Biomolecular Spatial Phenotyping


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative We propose a versatile and flexible light-sheet fluorescence microscopy (LSFM) platform, which will be able to perform a wide range of imaging applications, ranging from single cells to cleared tissues. LSFM are typically highly specialized instruments, but we hypothesize that versatility is needed to realize the full potential of LSFM in the life sciences. To study the efficacy of therapies, we will image calcium signaling and cytoskeletal structure in human derived cardiomyocytes, highlighting the adaptability and potential of our instrument in biomedical research.

PI_NAMEs: FIOLKA, RETO PAUL (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: 3-Dimensional;Acceleration;Actins;Algorithms;Architecture;Biological;Biological Process;biological research;Biological Sciences;biomedical imaging;Biomedical Research;Calcium;Calcium Signaling;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cells;cellular imaging;Computer software;Custom;Cytoskeleton;Data;Dedications;design;detection method;Disease;efficacy study;Embryo;Ensure;Feedback;flexibility;Fluorescence Microscopy;Future;Gel;Health;Homeostasis;Human;human imaging;Image;Image Analysis;imaging capabilities;imaging modality;improved;injured;Injury;innovation;instrument;Label;lens;Light;Lighting;live cell imaging;Methods;Microscope;Microscopy;Microtubules;Mitochondria;Modality;model organism;Molecular;Monitor;Nanosphere;Optics;Organ;patient derived induced pluripotent stem cells;Pattern;Performance;Protocols documentation;Quantitative Evaluations;reconstruction;Refractive Indices;Resolution;Sampling;Sarcoplasmic Reticulum;Sepharose;spatiotemporal;Speed;Spottings;Structure;superresolution imaging;superresolution microscopy;System;Techniques;temporal measurement;Testing;therapy development;Three-Dimensional Imaging;Time Series Analysis;Tissues;tool;translational applications;Treatment Efficacy

PROJECT_TITLE: Omni Oblique Plane Microscope to spread light-sheet based imaging in biomedical research

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Baylor College of Medicine (BCM) requests support for the acquisition of an Illumina NovaSeq X DNA sequencing instrument, to support the biomedical research community at BCM and throughout the Texas Medical Center. This instrument will benefit both basic and clinical research faculty by providing high-quality access to accurate and cost-efficient DNA sequence read data. As many of these groups work on translational medicine in many different fields, we expect an immediate, broad impact on human health.

PI_NAMEs: KRAUSHAAR, DANIEL  (contact)

PROJECT_TERMS: Basic Science;Biological Assay;Clinical Research;college;Communities;Consultations;Core Facility;cost;Data;Data Analyses;data integration;Discipline;empowerment;Ensure;epigenomics;experience;Experimental Designs;flexibility;Funding;Future;Genomic medicine;Genomics;Growth;human disease;Individual;Infrastructure;Institution;instrument;instrumentation;Laboratory Research;Libraries;Medical;Medical center;Medicine;Molecular;next generation;next generation sequencing;operation;Output;Play;Postdoctoral Fellow;Process;Quality Control;Research;Research Personnel;Research Project Grants;RNA;Role;Sampling;Services;Students;Technology;Texas;transcriptomics;United States National Institutes of Health

PROJECT_TITLE: HIGH THROUGHPUT NGS SEQUENCER AT THE BCM GENOMIC AND RNA PROFILING CORE

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-D (30)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Social anxiety is more common in women than in men, but the underlying mechanisms are unknown. The proposed experiments use rodent models to determine the mechanisms through which gonadal hormones shape neural circuits that mediate social approach and vigilance during adolescence.

PI_NAMEs: TOLLKUHN, JESSICA ;TRAINOR, BRIAN C (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Adolescence;Adolescent;Adolescent Development;Adult;Affect;Androgen Receptor;androgen sensitive;Androgens;Anterior;Anxiety;Behavior;behavior influence;Behavioral;behavioral response;Binding;Binding Sites;biological adaptation to stress;Biological Models;Brain;brain shape;California;Castration;Cell Culture Techniques;Cells;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Development;Electrophysiology (science);experimental study;Exposure to;Female;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Genomics;Gonadal Hormones;Hippocampus;Human;insight;knock-down;Knowledge;male;Mediating;Membrane;men;Mental Depression;mental development;Mental disorders;Methods;Modeling;Modernization;Molecular;Molecular Target;Mouse Strains;multiple omics;Mus;neural;neural circuit;Neurons;Neurosciences;Nucleus Accumbens;Pathway interactions;Pattern;Peromyscus;Post-Traumatic Stress Disorders;prepuberty;programs;Property;Puberty;Rat Strains;Rattus;Receptor Activation;receptor expression;Resolution;response;Risk;Risk Factors;RNA;Rodent;Rodent Model;sex;Sex Differentiation;Shapes;Slice;social;social anxiety;Social Behavior;social defeat;social stress;social stressor;Standard Model;Stanolone;Steroid Receptors;Stress;Structure;Structure of terminal stria nuclei of preoptic region;Technology;Testing;Testosterone;Tissues;tool;Transcript;Transcriptional Regulation;vigilance;Viral Vector;Woman;Women's prevalence;Work;XCL1 gene

PROJECT_TITLE: Developmental programming of stress-sensitive neural circuits underlying social behavior

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]