PHR: This supplement will allow the development of peptide macrocycles as drug candidates targeting BET proteins involved in regulating our innate immune response. BET proteins are also the target of multiple virus and their misregulation leads to different types of cancer. Our novel macrocycle strategy will target a new domain in BET proteins leading to lower side effects and toxicity than previous drug strategies.

PI_NAMEs: PEREZ, ALBERTO  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Administrative Supplement;cancer type;Chemistry;design;Development;Disease;drug candidate;Drug Targeting;Drug usage;Immune Response Genes;Innate Immune Response;novel;parent grant;Peptides;Pharmaceutical Preparations;Proteins;side effect;tool;Toxic effect;Virus

PROJECT_TITLE: Administrative Supplement - Desinging peptide macrocycles to selectively inhibit BET proteins: Martinez Noa, Yisel

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Physical Activity;Prevention;Substance Misuse

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10-year-olds to be followed over 10 years, to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the scientific community to address a comprehensive range of questions concerning youth development.

PI_NAMEs: JACOBUS, JOANNA ;TAPERT, SUSAN F (contact)

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;Adult;Affect;Alcohols;assessment application;Athletic Injuries;Behavioral;Biological;Biological Assay;Biology;Brain;Brain imaging;Caffeine;Cannabis;Child;Child Health;Childhood;Clinical assessments;Cognitive;cognitive development;cognitive testing;Communities;Country;Data;Data Analyses;Development;Emotional;emotional factor;Enrollment;Environment;Environmental Risk Factor;Event;experience;gene interaction;Health;Individual;Interview;Life;Longitudinal Studies;Mental Health;mobile application;Monitor;multimodality;neural;neuroimaging;Neuropsychological Tests;Outcome;Parents;Participant;participant enrollment;Pathway interactions;Persons;Physical activity;physical conditioning;Privatization;Recurrence;Research;research and development;Research Personnel;Research Project Grants;Resource Informatics;retention rate;Risk;Role;Sampling;Schools;Secure;Site;Sleep;sleep pattern;social;Social Functioning;social media;Specific qualifier value;Sports;substance use;Symptoms;Technology;Telephone;temporal measurement;Time;Tobacco;Traumatic Brain Injury;tv watching;United States;vaping;Video Games;young adult;Youth

PROJECT_TITLE: 5/21 ABCD-USA Consortium: Research Project Site at UC San Diego


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BALTIMORE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE 1R01GM149073 PARENT GRANT Cellular force sensing is essential for the proliferation of cells, normal development, and maintenance of a healthy organism. We seek to decipher how mechanical forces direct the localized assembly of key mechanosensory machinery, including nonmuscle myosin II proteins, and how these cellular responses lead to changes in cell behavior and identity.

PI_NAMEs: IGLESIAS, PABLO A.;ROBINSON, DOUGLAS N (contact);ROCK, RONALD S

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Adhesions;Biochemical Process;Biological Models;cell behavior;Cell Cycle Stage;Cell division;Cell Physiology;Cell Proliferation;cell type;Cells;Computer Models;cortexillin I;Cytoplasm;Cytoskeleton;Data;Development;Dictyostelium;Diffusion;Environment;Feedback;Gene Expression;Growth;Human;in vivo;Kinetics;Lead;Magnetism;Maintenance;Mass Spectrum Analysis;Measures;mechanical force;Mechanics;Modeling;Molecular;Morphogenesis;Motility;Motor;Myosin Type II;myosin-heavy-chain kinase;non-muscle myosin;Organism;Output;parent grant;particle;Positioning Attribute;Process;protein crosslink;Proteins;Publishing;Research;response;Signal Pathway;Signal Transduction;simulation;System;Testing;theories;Thick Filament;Tissues;Work

PROJECT_TITLE: Molecular Mechanisms of Cytoskeletal Mechanosensory Systems


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: NORTH LIBERTY

ORG_NAME: JMI LABORATORIES

ORG_STATE: IA

PI_NAMEs: ARENDS, RYAN  (contact)

PROJECT_TERMS: Advanced Development;Anti-Bacterial Agents;Bacteria;Biological Assay;combat;Combating Antibiotic Resistant Bacteria;Contracts;Development;Drug-resistant Neisseria Gonorrhoeae;in vitro testing;Maintenance;therapeutic development;Toxin

PROJECT_TITLE: Task A23: Antibiotic-Resistant Neisseria Gonorrhoeae MIC Determination


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Hematology;Nanotechnology;Rare Diseases;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Therapeutic genome editing has shown great promise for treating inherited hemoglobinopathies such as sickle cell disease, yet current approaches require ex vivo procedures that cannot generally be conducted in parts of the world where the prevalence and mortality of these diseases are greatest. The proposed project will engineer peptide-based nanoparticles for the delivery of therapeutic genome editing agents to targeted cell populations in vivo, eliminating the need for resource-intensive ex vivo processing. This research could serve as the basis for the development of hemoglobinopathy genome editing therapies that can be used globally, and establish an in vivo gene delivery platform for the treatment of other illnesses.

PI_NAMEs: EWEJE, FEYISAYO RONALD (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Affect;Antibodies;Bar Codes;Behavior;beta Thalassemia;Biodistribution;Biological Assay;biomaterial compatibility;biophysical properties;burden of illness;C-terminal;C57BL/6 Mouse;Cell Line;Cell Separation;Cells;Characteristics;Charge;Clinical Trials;Complementary RNA;Complex;conditioning;cost;curative treatments;Cytoplasm;delivery vehicle;density;design;Detection;Development;Dideoxy Chain Termination DNA Sequencing;Disease;DNA;DNA cassette;Drug Delivery Systems;Dyes;Elastin;Electrophoretic Mobility Shift Assay;Encapsulated;Endosomes;Engineering;Engraftment;Ensure;Equity;Exclusion;Flow Cytometry;fluorescence imaging;Formulation;Foundations;Gene Delivery;genetic variant;genome editing;genome editor;Guide RNA;Harvest;Hematological Disease;Hematopoietic Stem Cell Mobilization;Hematopoietic stem cells;Hemoglobinopathies;Housekeeping Gene;HPRT1 gene;Human;immunogenicity;In Vitro;in vivo;Inherited;intravenous administration;Investigation;Label;Lead;Length;Libraries;Life Expectancy;low and middle-income countries;Mediating;Mendelian disorder;Messenger RNA;Monoclonal Antibodies;mortality;mouse model;mRNA delivery;Mus;nanoparticle;nanoparticle delivery;Newborn Infant;next generation sequencing;novel;nucleic acid delivery;nucleic acid-based therapeutics;Nucleic Acids;Oligonucleotides;Organ;Particle Size;Pathologic;Peptides;Peripheral;peripheral blood;Phase;Polymers;polypeptide;Population;Prevalence;Procedures;Process;Property;Proteins;receptor binding;Recombinants;repaired;Reporting;Research;Research Proposals;Resources;RNA;RNA Binding;Scheme;self assembly;Series;Sickle Cell Anemia;small molecule;sortase;Sorting;Specificity;stem cell delivery;stoichiometry;Structure;Surface;System;Thalassemia;therapeutic genome editing;tissue fixing;Tissues;Transfusion;Tropism;uptake;vector;Wild Type Mouse;Work

PROJECT_TITLE: Self-Assembling Peptide Nanoparticles for in vivo Genome Editor Delivery to Hematopoietic Stem Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Dissemination and Implementation Research;Health Services

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The application of patient reported outcome measures (PROMs) for peripheral arterial disease (PAD) patients will allow for improved detection of health changes and incorporate a patient voice into PAD clinical care. This study fills contextual gaps for using PROMs in the healthcare delivery for PAD, provides a rigorous and replicable process for the identification of patient perceptions, and develops a strategy for meaningfully engaging stakeholders in the deployment of implementation strategies. The achievement of the proposed aims will produce a generalizable strategy to promote PROM clinical utilization and patient-centered care for PAD patients.

PI_NAMEs: HOLEMAN, TERYN ALLENE (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Achievement;Adult;Ankle;Blood flow;blood flow measurement;Blood Vessels;care delivery;Caring;Characteristics;Chronic;Clinic;Clinical;clinical care;clinical outcome measures;clinical practice;Communication;Data;Data Analyses;Delphi Technique;design;Detection;Disease Progression;Effectiveness;effectiveness/implementation hybrid;Environment;Exercise Therapy;Fellowship;Focus Groups;Foundations;Future;future implementation;Goals;Health;health care delivery;human old age (65+);implementation efforts;implementation framework;implementation science;implementation strategy;improved;indexing;Institution;Intervention;Interview;Joints;Knowledge;Learning;Limb structure;Managed Care;Measures;Medical;Mental Depression;Mentorship;Modeling;Monitor;Morbidity - disease rate;mortality;National Research Service Awards;Operative Surgical Procedures;Outcome;Outcome Measure;Patient Care;Patient Outcomes Assessments;Patient-Centered Care;Patient-Focused Outcomes;Patients;Perception;Peripheral arterial disease;Physical Function;Process;prospective;Provider;Psyche structure;Qualifying;Qualitative Research;Quality of life;Recovery;Reporting;Research;Research Methodology;Resources;revascularization;routine care;Scientist;skills;social;social engagement;Solid;Statistical Methods;Structure;success;Surgeon;Surgical Management;Time;time use;tool;Training;Translating;United States;Voice;Work

PROJECT_TITLE: Implementation and Effectiveness of Patient Reported Outcome Measures for Peripheral Arterial Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-E(20)L]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE  Excessive growth of the cardiac muscle frequently occurs during the progression to heart failure. In a small percentage of patients, existing therapies can reverse this growth, which leads to improved outcomes; however, efforts to specifically target this process are not yet possible because the cellular factors involved are poorly understood. The work proposed in this fellowship will seek to identify whether targeting specific molecules implicated in muscle remodeling may offer a new therapeutic avenue for reversing unhealthy growth and improving cardiac function in patients with heart disease.

PI_NAMEs: MARTIN, THOMAS GWYNN (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: adenoviral mediated;Adenoviruses;Agonist;Animal Model;Arrhythmia;Autophagocytosis;Biology;Burmese;Cardiac;Cardiac Myocytes;career;Cell model;Chronic;Clinical;Clinical Research;constitutive expression;Dependovirus;design;Development;Digestion;Disease;drug development;Dryness;Eating;Excision;Exercise;Exhibits;experience;experimental study;Exposure to;Fellowship;Fibrosis;forkhead protein;Gene Targeting;gene therapy;Genes;Goals;Growth;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Hour;human induced pluripotent stem cells;Hypertension;Hypertrophy;improved;improved outcome;In Vitro;in vivo;induced pluripotent stem cell derived cardiomyocytes;Ingestion;Insulin-Like Growth Factor I;Isoproterenol;knock-down;Knock-out;Lead;Left ventricular structure;Longevity;Mediating;Metabolic;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;Muscle Cells;Myocardial Infarction;Myocardium;Neonatal;new therapeutic target;novel therapeutics;Organ;overexpression;Pathologic;Pathway interactions;patient subsets;Patients;physiologic model;physiologic stressor;Physiological;Postpartum Period;Pregnancy;pregnant;pressure;prevent;Prevention;Process;Proteins;Proteolysis;Pythons;Quality Control;Quality of life;Rattus;Research;Research Personnel;response;Risk;Risk Factors;Role;Running;Serotyping;Serum;Signal Transduction;Small Interfering RNA;small molecule inhibitor;Stimulus;targeted treatment;Testing;Therapeutic;therapeutic target;Time;Up-Regulation;Ventricular;Wild Type Mouse;Work

PROJECT_TITLE: The role of FOXO1 in the development and regression of cardiac hypertrophy


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Orphan Drug;Pediatric;Prevention;Rare Diseases

ORG_DEPT: NUTRITION

PHR: PROJECT NARRATIVE The ultimate goal of the proposed research is to evaluate the mechanistic role of ceramides as mediators of heart failure in patients with Very Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCADD) and to uncover novel therapeutic targets to ameliorate disease pathogenesis. This is important because children with severe VLCADD continue to experience early mortality due to heart failure despite advances in newborn screening and treatment. Thus, the proposed research is relevant to the mission of the NIH that pertains to developing fundamental knowledge that will help to reduce the burdens of human disease and disability.

PI_NAMEs: NORRIS, MARIE KRISTINE (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: acylcarnitine;Age;Apoptosis;Biological Markers;Body Weight;Brain natriuretic peptide;Cardiac;Cardiomyopathies;Cardiovascular Diseases;cardiovascular risk factor;career;Cells;Ceramides;Cessation of life;Child;Child Mortality;Childhood;Clinic;Clinical;clinical biomarkers;Cre lox recombination system;Data;Death Rate;Defect;Development;disability;Disease;Disease Progression;Doxycycline;Dyslipidemias;early experience;Echocardiography;Enzymes;experience;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;Fellowship;Fibrosis;Genes;Goals;Heart;heart disease risk;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Histopathology;Human;human disease;Impairment;improved;In Vitro;in vivo;in vivo Model;Informed Consent;Institutional Review Boards;Knockout Mice;Knowledge;Length;lipidomics;Lipids;Logistic Regressions;long chain fatty acid;Long-Chain-Acyl-CoA Dehydrogenase;Measures;Mediating;Mediator;Metabolic;Metabolism;Methods;Mission;Mitochondria;Modeling;Modification;Morphology;mortality;mouse model;Mus;Myocardial dysfunction;Myosin Heavy Chains;Neonatal Screening;new therapeutic target;novel;novel therapeutic intervention;Obesity;overexpression;oxidation;Pathogenesis;Pathology;Pathway interactions;patient population;Patients;Pharmacologic Substance;Phenotype;Plasma;Play;pre-doctoral;premature;prevent;Production;promoter;Research;Risk;Risk Marker;ROC Curve;Rodent;Role;Sampling;Scientist;serine palmitoyltransferase;Severity of illness;sex;Signal Transduction;Tamoxifen;Technical Expertise;Testing;therapeutic target;tibia;Tissues;Training;transcriptomics;Transgenes;Transgenic Mice;Transgenic Organisms;United States National Institutes of Health;Universities;Utah;VLCAD deficiency;VLCADD patient;Weight;Work

PROJECT_TITLE: Ceramides as Novel Mediators of Very Long-Chain Acyl-CoA Dehydrogenase Deficiency-Induced Heart Failure.


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Improving treatment of prostate cancer is critically relevant to Veterans’ health. Prostate cancer is diagnosed in approximately 12,000 American Veterans annually and accounts for one third of all cancer diagnoses in American male Veterans. It is the second leading cause of cancer death in American male Veterans. Metastatic castration resistant prostate cancer is lethal. Immunotherapies that are effective in other cancers, such as checkpoint blockade, are rarely effective in castration resistant prostate cancer. However, some patients with lethal prostate cancers who harbor certain molecular features may respond to checkpoint blockade. We will analyze the tumors of 200 Veterans with metastatic castration resistant prostate cancer for these molecular features that might predict response to checkpoint blockade. We will then conduct a Phase II clinical trial of checkpoint blockade with the drug pembrolizumab in these patients as well as further molecular assessments of the tumors to learn which patients respond best to this treatment.

PI_NAMEs: RETTIG, MATTHEW B (contact)

PROJECT_TERMS: Affect;Alleles;alternative treatment;American;analytical tool;androgen independent prostate cancer;antitumor effect;Biological Assay;Biology;biomarker identification;Biopsy;Blood specimen;cancer diagnosis;Cancer Etiology;Cancer Patient;Cessation of life;Characteristics;checkpoint inhibition;checkpoint therapy;CLIA certified;clinical efficacy;Colon Carcinoma;Cyclin-Dependent Kinases;Data;Dedications;Detection;detection assay;detection sensitivity;Diagnosis;effective therapy;efficacy evaluation;Eligibility Determination;epigenetic silencing;Exhibits;exome;Frequencies;Gene Fusion;Gene Mutation;Genes;Genetic;Genome Stability;Genomics;Head and Neck Cancer;Health;Hodgkin Disease;Human;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;immunogenic;Immunologic Factors;Immunotherapy;improved;inhibitor;insertion/deletion mutation;Knowledge;Large Intestine Carcinoma;Learning;Lesion;Life;Lymphoma;Maintenance;male;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Melanoma;men;Mentored Clinical Scientist Development Program;Microsatellite Instability;military veteran;Mismatch Repair;Mismatch Repair Deficiency;Molecular;Molecular Target;Monoclonal Antibodies;Mutation;Neck Cancer;neoantigens;Neoplasm Metastasis;next generation sequencing;Non-Small-Cell Lung Carcinoma;novel strategies;objective response rate;oncology program;open label;Open Reading Frames;Patient Selection;Patients;pembrolizumab;Pharmaceutical Preparations;phase 2 study;Phase II Clinical Trials;Phenotype;Point Mutation;Population;precision oncology;predicting response;Primary carcinoma of the liver cells;primary endpoint;Primary Neoplasm;Progression-Free Survivals;prospective;Prospective cohort;Prospective Studies;Prostate Cancer therapy;Proteins;Proteomics;Quality of life;radiological imaging;Renal Cell Carcinoma;Reporting;Resistance;response;response biomarker;sequencing platform;Signal Transduction;Site;Somatic Mutation;success;tool;transcriptomics;Transitional Cell Carcinoma;tumor;Veterans

PROJECT_TITLE: A Phase 2 study of a Checkpoint Inhibitor in Men with Progressive Metastatic Castrate Resistant Prostate Cancer Characterized by a Mismatch Repair Deficiency or Biallelic CDK12 Inactivation


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE Through this project, Implementing and Evaluating CDC’s What Works in Schools Approach in Rural School Districts, RTI International will partner with Child Trends, Inc., and two local education agencies in rural northwestern North Carolina to learn how to best improve health for students in those districts. The research team will work with students, parents, school staff, and community members to better understand what schools and entities working with schools can do to improve student health and increase school attendance. The findings from this research will be widely shared with other school districts, with a focus on those serving rural students.

PI_NAMEs: SUELLENTROP, KATY MICHELLE (contact)

PROGRAM_OFFICER_NAME: SANDERS, CELESTE

PROJECT_TITLE: DP24-138 Implementing and Evaluating CDC's What Works in Schools Approach in Rural School Districts

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 OHI (11)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Human Genome;Lung;Orphan Drug;Pediatric;Precision Medicine;Prevention;Pulmonary Hypertension;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Pulmonary hypertension (PH) is a serious, potentially life-threatening disorder affecting the blood vessels of the lung, which can lead to heart failure. Its causes are complex and not well understood. Hereditary hemorrhagic telangiectasia (HHT) is a related inherited abnormality of the blood vessels that can lead to serious bleeding, including strokes, and can also cause PH. This study will characterize the genetic changes that predispose to PH and HHT, and test new therapeutic approaches to correct these defects. The long term goals are to better understand what causes pulmonary vascular disease and who is most at risk, in order to improve diagnosis, identify new therapies and work towards disease prevention.

PI_NAMEs: ALDRED, MICHEALA A (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Affect;Arteriovenous malformation;Award;Blood;Blood Cells;Blood Vessels;Bone Morphogenetic Proteins;Brain;Cardiac Catheterization Procedures;Catheters;Cells;Chromosome abnormality;Complex;Data;Defect;Diagnosis;diagnostic signature;Disease;Disease Progression;disorder prevention;DNA analysis;DNA Damage;Endothelial Cells;Etiology;Evolution;Funding;Genetic;Genetic Variation;Genomics;Germ Lines;Goals;Heart failure;Hemorrhage;Hereditary hemorrhagic telangiectasia;improved;In Vitro;Inherited;innovation;Leadership;Life;Liver;Lung;Molecular;Morbidity - disease rate;mouse model;Mutation;National Heart, Lung, and Blood Institute;next generation sequencing;Nonsense Mutation;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;Orphan Drugs;Pathway interactions;Patients;Pharmaceutical Preparations;Precision therapeutics;Prevention;prognostic signature;programs;public health relevance;pulmonary arterial pressure;pulmonary artery endothelial cell;Pulmonary Hypertension;pulmonary vascular disorder;pulmonary vascular remodeling;Reactive Oxygen Species;Research;Research Personnel;Resolution;response;Ribosomes;right ventricular failure;Risk;Signal Pathway;Signaling Protein;single cell sequencing;small molecule;Somatic Mutation;Stroke;Structure of parenchyma of lung;Technology;Telangiectasis;Testing;Vascular Diseases;Vascular remodeling;Work

PROJECT_TITLE: Genomics of Pulmonary Vascular Disease


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Contraception/Reproduction;Depression;Estrogen;Headaches;Mental Health;Mental Illness;Migraine;Neurosciences;Pain Research;Women's Health Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE During hormonally active periods, individuals are at greater risk of affective disorders, particularly if they experience comorbid migraine. The proposed research aims to evaluate migraineurs as a unique phenotype of individuals with affective disorders due to their vulnerability to hormonal fluctuations using passive and ecological momentary assessment smartphone data. This project will enhance prospective cohort data collection of episodic conditions and improve mental health risk assessment, screening, and treatment for migraineurs, those suffering from affective disorders, and those with this common comorbidity.

PI_NAMEs: CROWE, HOLLY MICHELLE (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Adolescent;Adult;Affect;Age;aged;Anxiety;Award;career;Cellular Phone;Characteristics;Child;Childbirth;Cohort Studies;comorbidity;Data;Data Collection;data modeling;design;Development;digital phenotyping;disabling disease;Disease;Ecological momentary assessment;Epidemiologic Measurements;Exhibits;experience;Female;female sex hormone;Functional disorder;Functional impairment;girls;high dimensionality;High Prevalence;high risk;High-dimensional Modeling;Hormonal;hormone therapy;Hospitals;improved;Individual;Life;Life Cycle Stages;life span;lifestyle factors;Link;longitudinal analysis;Measurement;medical schools;Menopause;Menstrual cycle;Menstruation;Mental Depression;Mental disorders;Mental Health;Mentorship;Methods;Migraine;Mood Disorders;Moods;Neurosecretory Systems;novel;Nurses' Health Study;Participant;Perimenopause;Persons;Phenotype;Play;Population;Postpartum Depression;Postpartum Period;premenstrual dysphoric disorder;Premenstrual syndrome;Prospective cohort;Prospective, cohort study;psychiatric comorbidity;psychiatric symptom;Puberty;Public Health Schools;Quality of life;Recurrence;Reporting;reproductive;reproductive epidemiology;Research;Research Personnel;Resources;Risk;Risk Assessment;Risk Factors;Role;Scientist;screening;skill acquisition;skills;Symptoms;Testing;Time;Training;Volatilization;Woman;Work;young adult

PROJECT_TITLE: Characterization and Digital Phenotyping of Migraine and Affective Disorders during Hormonal Fluctuations across the Life Course

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases;Lung

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Public Health Relevance Statement Dendritic cells (DC) are professional antigen presenting cells that serve critical roles in both innate and adaptive immune responses. This project investigates how DC focally deliver cytokines like interleukin 33 to T cells for shaping the inflammatory vs. anti-inflammatory responses generated within the respiratory mucosa through mechanisms dependent upon the enigmatic pore-forming protein Perforin-2.

PI_NAMEs: HERBERT, DE'BROSKI R (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Acute;adaptive immune response;Address;Adopted;airborne allergen;Airway Disease;Anti-Inflammatory Agents;Antigen-Presenting Cells;Antigens;Automobile Driving;B-Lymphocyte Subsets;Bacteria;Biochemical;Biological Assay;Bone Marrow;Cell Communication;Cell Death;Cell membrane;Cell Physiology;Cell Shape;Cells;Cellular biology;Chimera organism;chromatin immunoprecipitation;Chronic;chronic inflammatory disease;chronic rhinosinusitis;cytokine;Cytolysis;Cytoplasm;Data;Dendritic Cells;Development;Disease;draining lymph node;experimental study;Exposure to;Family;FOXP3 gene;GATA3 gene;Genes;Genetic Transcription;Growth Factor;helminth infection;Helminths;Human;IFNAR1 gene;Immunity;immunoregulation;Immunosuppression;Impairment;Infection;Inflammation;Inflammatory;Inflammatory Response;Influenza A virus;Inhalation;Innate Immune Response;Interferons;Interleukin-1;Interleukins;IRF4 gene;ITGAX gene;Location;Macrophage;mass spectrometric imaging;Mass Spectrum Analysis;Mediating;Mediator;Membrane;microbicide;Molecular;mouse model;Mucous Membrane;Mus;mutant;Myelogenous;N-terminal;Nasal Polyps;Necrosis;novel;Operative Surgical Procedures;Parasites;pathogen;Pathway interactions;Patients;Peptide Signal Sequences;perforin 2;Phagolysosome;Population;prevent;programs;protein aminoacid sequence;Protein Secretion;Proteins;public health relevance;Reagent;receptor;Regulatory T-Lymphocyte;Reporting;respiratory infection virus;Respiratory Mucosa;respiratory pathogen;respiratory virus;response;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Specimen;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Testing;theories;Therapeutic Intervention;Tissues;trafficking;transcription factor;VDAC1 gene;Virus;Virus Diseases;Work

PROJECT_TITLE: Perforin 2 controls unconventional cytokine release from mucosal APC


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: CHESTNUT HILL

ORG_DEPT: CHEMISTRY

ORG_NAME: BOSTON COLLEGE

PHR: Project Narrative. Single-enantiomer chiral compounds are vitally important as new materials and as medicinally relevant therapies. The proposed research will develop new technologies for the construction of such compounds from simple, readily available natural resources.

PI_NAMEs: MORKEN, JAMES PATRICK (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Address;Coupling;enantiomer;Equipment;functional group;Medicine;Natural Resources;new technology;Organic Synthesis;Process;Reagent;Research;Techniques

PROJECT_TITLE: New Strategies in Catalytic Organic Synthesis with Organoboron Reagents

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Epilepsy;Mental Health;Neurodegenerative;Neurosciences;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PI_NAMEs: TARASCHENKO, OLGA  (contact)

PROGRAM_OFFICER_NAME: KRASNOVA, IRINA N

PROJECT_TERMS: Adult;Affect;Age Years;Aging;Alzheimer's disease model;anakinra;Animals;antagonist;arm;Attenuated;attenuation;Autoimmune;Autoimmune encephalitis;behavior test;Behavioral;Brain Diseases;Brain imaging;Cells;Chemicals;Chronic;Cognitive;Cognitive deficits;cognitive function;cognitive neuroscience;Coma;Complication;Confusion;Data;Development;Encephalitis;Encephalopathies;Exposure to;Failure;Fc Receptor;Functional disorder;Goals;Hippocampus;Histologic;Image;Impaired cognition;in vivo;Inflammation;Inflammatory;Intervention;Learning;Literature;Memory;Memory impairment;Memory Loss;mouse model;Mus;N-Methyl-D-Aspartate Receptors;nerve stem cell;neurogenesis;novel therapeutic intervention;Patients;Pattern;Persons;pharmacologic;phenotypic biomarker;Positron-Emission Tomography;Proliferating;Proteins;Psychoses;Quality of life;Radiolabeled;receptor;restoration;Role;Seizures;stem cells;Thymidine;Tissues;Visualization

PROJECT_TITLE: The role of hippocampal neurogenesis in the development of cognitive deficits in autoimmune encephalitis with seizures


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Sexually Transmitted Infections

ORG_DEPT: OTOLARYNGOLOGY

PHR: Project Narrative: HPV+ HNSCC is a growing health burden in the US with numerous treatment-related morbidities, highlighting the need for novel targeted therapies. Inhibition of the cell cycle kinase WEE1 is a promising therapeutic strategy for HNSCC, and for HPV+ HNSCC in particular. This proposal seeks to investigate how HPV compromises DNA damage responses to WEE1 inhibition in order to identify novel synthetic lethal interactions with WEE1 in HPV+HNSCC.

PI_NAMEs: DIAB, AHMED MOHAMED (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: antitumor effect;Attenuated;Award;biological adaptation to stress;Biological Markers;cancer cell;Cancer Model;carcinogenesis;CDC2 gene;Cell Cycle Inhibition;Cell model;Cells;chemoradiation;chemotherapy;Cisplatin;Combined Modality Therapy;Competence;cytotoxic;Data;Defect;Development;Disease;DNA Damage;DNA Repair Pathway;DNA replication fork;Dose;Failure;Flow Cytometry;FOXM1 gene;Future;Gene Expression;Genes;Genetic;Genetic Screening;Genomic Instability;genotoxicity;Goals;Head and Neck Squamous Cell Carcinoma;Health;HPV E7;HPV positive;HPV-negative head and neck cancer;Human;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;hydroxyurea;Immune;Immunocompetent;Immunodeficient Mouse;Impairment;Implant;improved;In Vitro;in vitro testing;in vivo;in vivo evaluation;inhibitor;insight;keratinocyte;Libraries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Metastatic Neoplasm to the Lung;Mitosis;Mitotic;Modeling;Morbidity - disease rate;mouse model;multiple reaction monitoring;Mus;Neoplasm Metastasis;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Nucleotides;Oncogenes;Oncogenic;Oncoproteins;oral HPV-positive head and neck cancers;Outcome;overexpression;Papillomavirus Transforming Protein E6;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;premature;Prognosis;programs;Proliferating;Proteins;Proteomics;Public Health;rational design;Recurrence;Regimen;replication stress;Research;response;RNA Interference;RNA interference screen;S phase;Scientific Advances and Accomplishments;Signal Transduction;small molecule;synergism;synthetic lethal interaction;targeted treatment;Testing;Therapeutic;therapeutic candidate;TOPBP1 Gene;Toxic effect;Training;translational potential;treatment response;Triapine;tumor;tumor microenvironment;Tumor Suppressor Proteins;tumorigenesis;United States

PROJECT_TITLE: Targeting the DNA Damage Response in HPV+ Head and Neck Cancer

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Narrative More than 200,000 patients every year are affected by malignant brain tumors, which show very high proliferation with increased energy demand for their growth. The goal of this administrative supplement proposal is to secure a new -80? C freezer to securely store all the snap-frozen tumor tissue specimens from the patients enrolled for the parent R01 grant. The purchase of the new freezer for the study will minimize the variabilities in the metabolite measurements through the optimal storage of the snap- frozen tumor tissues prior to the analytical measurements.

PI_NAMEs: PICHUMANI, KUMAR  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Acetates;Acetyl Coenzyme A;Address;Administrative Supplement;Affect;Agreement;beta-Hydroxybutyrate;Bioenergetics;Biological;Brain Neoplasms;brain tumor resection;cancer cell;Carbon;Cell Line;Citric Acid Cycle;clinical development;Clinical Protocols;cold temperature;Complex;cost;Data;Death Rate;Dedications;Dehydration;design;Development;DNA;drug development;Electronics;Energy Metabolism;Enrollment;Ensure;Environment;Equipment;Excision;experimental analysis;Failure;Freezing;Future;Generations;Glioma;Glucose;Goals;Grant;Growth;Heterogeneity;High temperature of physical object;Human;Hydrolysis;Immunohistochemistry;improved;in vivo;Infusion procedures;Institutional Review Boards;interest;Intravenous infusion procedures;Ketone Bodies;Knowledge;Lead;Link;Location;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;mass spectrometric imaging;Mass Spectrum Analysis;Measurement;Mechanics;Metabolic;Metabolism;metabolomics;Metastatic malignant neoplasm to brain;Methods;Mutate;neoplastic cell;NMR Spectroscopy;Normal Cell;novel marker;novel therapeutics;Nutrient;Operating Rooms;Operative Surgical Procedures;Outcome Study;oxidation;parent project;Parents;participant enrollment;Patients;Performance;Pilot Projects;Plasma;Preclinical Testing;preservation;Primary Brain Neoplasms;Process;programs;Proliferating;Property;Proteins;Proteome;Protocols documentation;Radioactivity;Reporting;Research;Resected;RNA;Sampling;Schiff Bases;Secure;Serum;Slice;small molecule inhibitor;Source;Specimen;Technology;Temperature;time interval;Tissues;touchscreen;tumor;tumor diagnostic;tumor metabolism;Tumor Tissue;United States National Institutes of Health;Western Blotting;Work

PROJECT_TITLE: Administrative Supplement to Existing NIH Grant-Purchase of a Equipment


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Genetics;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Emergence of Plasmodium falciparum strains with resistance to first-line artemisinin-combination therapies threatens malaria control and elimination efforts across the Horn of Africa. Improved understanding of the epidemiology and determinants of drug-resistant falciparum malaria, including infections by drug- and diagnostic-resistant strains with hrp2/3 deletions, is needed to inform clinical management and policy decisions in the region. We will conduct population surveys across Ethiopia and characterize resistant parasites, integrating our findings into a point-of-care clinical tool for identifying individuals with drug-resistant falciparum malaria and into a model to predict the future spread of resistance mutations.

PI_NAMEs: PARR, JONATHAN BOYD (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: accurate diagnosis;Address;Affect;Africa;alternative treatment;Anti-malarial drug resistance;Anti-malarials;arm;Artemisinins;Behavioral;Cessation of life;Clinic;Clinical;clinical care;Clinical Management;clinical practice;clinical predictors;clinical risk;Collaborations;Collection;Combined Modality Therapy;Communities;Complex;cost;Country;Culicidae;Data;Deletion Mutation;design;Detection;Development;Diagnosis;Diagnostic;diagnostic strategy;Diagnostic tests;Drug resistance;effective therapy;Environment;Epidemiology;Ethiopia;Ethiopian;experimental study;Falciparum Malaria;fitness;Future;Gene Deletion;Genes;Genetic;Genetic Polymorphism;Health;Health care facility;Horns;HRP-2 protein;Human;human model;improved;In Vitro;in vivo;Incidence;Individual;Infection;Investments;Malaria;Mediating;migration;Modeling;Monitor;Movement;multiple data sources;Mutation;Parasite resistance;Parasites;Persons;Pharmaceutical Preparations;Plasmodium falciparum;point of care;Policies;Population;population survey;Positioning Attribute;predictive modeling;predictive tools;pressure;Prevalence;prevent;programs;prospective;Public Health;rapid diagnosis;Rapid diagnostics;Regimen;Reporting;Residencies;Resistance;resistance mutation;Resistance to infection;resistant Plasmodium falciparum;resistant strain;Risk;Risk Factors;risk prediction model;Selection for Treatments;Statistical Models;Surveys;Testing;therapy design;Time;tool;transmission process;Travel;treatment strategy;Uncertainty;Vertebral column

PROJECT_TITLE: Epidemiology and determinants of emerging artemisinin-resistant malaria in Ethiopia

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ADMINISTERING_IC: IP

IC_NAME: NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES

ORG_CITY: JOHANNESBURG

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: NATIONAL HEALTH LABORATORY SERVICE

PHR: PROJECT NARRATIVE This project will provide critical data to improve approaches to disease surveillance in Africa and expand capacity for evaluation of influenza immune responses. It will also provide data on the efficacy and mechanism of illness prevention of select existing and novel influenza vaccines and support interventions to scale up and maintain increased influenza vaccine coverage among high risk groups in South Africa and the region.

PI_NAMEs: COHEN, CHERYL  (contact)

PROJECT_TITLE: IP24-017 - Collaborative research on influenza and other respiratory pathogens in South Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZIP1 GCA (65)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CHICAGO

ORG_DEPT: NEUROSURGERY

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: PROJECT NARRATIVE This proposal is relevant to public health because it focuses on the association between silent brain infarcts in intracerebral hemorrhage (ICH) and vascular cognitive impairment and dementia. This proposal will enable the identification of biomarkers that may inform future treatments to improve long-term cognitive outcomes in ICH survivors. This project is relevant to NINDS’s mission to accelerate the development of therapies to reduce the cognitive morbidity associated with strokes.

PI_NAMEs: GARG, RAJEEV KUMAR (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Acceleration;Accounting;Acute;Affect;Algorithmic Analysis;Automobile Driving;Biological Markers;biomarker identification;Blood Vessels;Brain Infarction;brain magnetic resonance imaging;C-reactive protein;Cerebral hemisphere hemorrhage;Cerebral Infarction;Cerebrum;Chronic;Clinical;Clinical Trials;Cognition;Cognitive;cognitive function;cohort;Cohort Studies;Data;Dementia;Development;Disease;Disease Outcome;Early treatment;epidemiologic data;Episodic memory;Event;Exhibits;Fingers;functional outcomes;Funding;Future;General Population;Goals;Hematoma;high risk;Hospitalization;Hospitals;Image;Impaired cognition;improved;improved outcome;Incidence;Individual;Inflammatory;inflammatory marker;Injury;innovation;Interleukin-6;Intervention;ischemic injury;Knowledge;Lead;Link;Literature;Magnetic Resonance Imaging;Measures;Mendelian randomization;Mission;Modeling;Modification;Morbidity - disease rate;National Institute of Neurological Disorders and Stroke;neuroimaging marker;Neurologic Deficit;novel;novel marker;novel strategies;novel therapeutics;Outcome;Participant;Patients;Persons;prevent;prognostic;Prognostic Marker;Proteins;Public Health;recruit;Research;Risk;Risk Factors;Role;secondary analysis;Serial Magnetic Resonance Imaging;Serum;Short-Term Memory;Stroke;Survivors;systemic inflammatory response;Techniques;Testing;therapeutic evaluation;Therapeutic Intervention;therapy development;Toxin;treatment strategy;treatment trial;United States;United States National Institutes of Health;Urokinase Plasminogen Activator Receptor;vascular cognitive impairment and dementia;vascular inflammation;vascular risk factor;White Matter Hyperintensity

PROJECT_TITLE: Silent Brain Infarcts in Spontaneous Intracerebral Hemorrhage as a Prognostic Biomarker for Vascular contributions to Cognitive Impairment and Dementia (VCID)

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: SAN DIEGO

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Public libraries nationwide are experiencing an on-premise opioid overdose crisis. U.S. overdose deaths increased 30% in 2020, with many persons with opioid use disorder (OUD) remaining unhoused and profoundly hard to reach. Therefore, this study will be the first to develop and test a telehealth intervention delivered through public libraries to reduce opioid-related deaths by increasing unstably housed individuals’ buprenorphine medication access and adherence.

PI_NAMEs: URADA, LIANNE A (contact)

PROGRAM_OFFICER_NAME: HERRMANN, EVAN SULLIVAN

PROJECT_TERMS: 2 arm randomized control trial;Address;Adherence;arm;Attitude;Books;Buprenorphine;Businesses;Caring;Child;Cities;Client satisfaction;Clinic;Clinical;Collaborations;Computers;Control Groups;County;Daughter;design;Dose;Drug Prescriptions;Drug Screening;efficacy evaluation;eligible participant;Emergency Medicine;Environment;Evidence based treatment;experience;Fathers;Focus Groups;Foundations;Health;Health Personnel;Homeless persons;Homelessness;housing instability;implementation barriers;improved;Individual;individualized medicine;innovation;insight;Intention;Internet;Intervention;intervention mapping;Intervention Trial;Interview;Libraries;Location;Measures;Medical;Mental Health;Methodology;Methods;Modeling;naloxone carriage;National Institute of Drug Abuse;Nurses;opioid mortality;opioid overdose;opioid use disorder;outreach;Overdose;overdose death;Parents;Participant;Patient Self-Report;Patients;peer;Perception;Persons;Pharmaceutical Preparations;Pharmacy facility;Population;prevent;Privacy;Privatization;programs;Provider;Randomized;Randomized, Controlled Trials;recruit;relapse prevention;Reproducibility;Research;Resources;Security;Series;Site;Social Workers;Strategic Planning;Structure;Substance Use Disorder;Techniques;Technology;telehealth;Telemedicine;Testing;Training;Transportation;Treatment Efficacy;treatment planning;uptake;urinary;Work

PROJECT_TITLE: Bupe by the Book: Developing and Testing a Tele-Buprenorphine Intervention in Public Libraries with Unstably Housed Persons with Opioid Use Disorder


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: ITHACA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative (relevance) Many human diseases arise from defects in the subcellular membrane and protein sorting machinery and its regulators. This project investigates the function and regulatory mechanisms of key proteins controlling sorting that are essential for cell viability.

PI_NAMEs: FROMME, J CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Biochemical;Biological;Biological Assay;Cell membrane;Cell Survival;Cells;Communication;Defect;Destinations;Endoplasmic Reticulum;Endosomes;Eukaryotic Cell;Experimental Genetics;experimental study;Family;genetic approach;glycosylation;Golgi Apparatus;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;human disease;In Vitro;in vivo;live cell imaging;Logic;Lysosomes;Membrane;Membrane Protein Traffic;Molecular;mutant;Nucleotides;Organelles;Pathway interactions;Physiological;Process;programs;protein protein interaction;Protein Sortings;Proteins;Proteomics;Reaction;reconstitution;recruit;Regulation;Research;Role;Signal Transduction;Site;Sorting;structural biology;tool;trafficking;Vesicle;Visualization;Work

PROJECT_TITLE: GTPase Regulation of the Golgi Complex

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE The protein phosphatases PP1 and PP2A are ubiquitous ser/thr protein phosphatases that are critical during mitosis. Despite decades of research, most PP1 and PP2A substrates are still unknown. This FPLC, with our assembled team of researchers, will overcome this challenge to allow for novel biological insights to be gained.

PI_NAMEs: PAGE, REBECCA  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Affinity;Biological;biophysical analysis;CDC2 gene;Cell division;Cell Nucleus;Cells;Chromatography;cost;design;Disease;Drug Targeting;Enzymes;experimental study;Family;fast protein liquid chromatography;Goals;Health;Holoenzymes;human disease;inhibitor;insight;Knowledge;Lead;Malignant Neoplasms;Mitosis;Mitotic;Molecular;novel;Phosphoric Monoester Hydrolases;Phosphorylation;Process;Protein Dephosphorylation;protein function;Protein phosphatase;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;Proteome;recruit;Regulation;Reproducibility;Research;Research Personnel;Role;Sampling;Signal Transduction;Specificity;System;Systems Biology;Work

PROJECT_TITLE: The regulation of phosphoprotein phosphatases in the nucleus

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE: This proposal will be the first to simultaneously examine trajectories, and modifiable risk factors, of structural and functional brain decline, gait decline, and cognitive decline in aging and pre- dementia. This proposal has the potential to directly inform the development of targeted, and appropriately sequenced, interventions for maintaining gait and cognition in aging and pre-dementia.

PI_NAMEs: BLUMEN, HELENA M (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acceleration;Address;Affect;Age;age related;age-related disease;Aging;aging brain;aging related;Alzheimer's disease related dementia;Area;Atrophic;Biological;Brain;Caregivers;Caring;Clinical;Cognition;Cognitive;cognitive testing;Communities;cost effective;cost estimate;Cues;Data;Dementia;dementia risk;Development;Direct Costs;disability;effective therapy;Emergency Situation;Enrollment;executive function;fall injury;falls;Family;Family member;follower of religion Jewish;Friends;Functional Magnetic Resonance Imaging;Future;Gait;Gait abnormality;Gait speed;Genetic;gray matter;Health Care Costs;healthy aging;Human;Image;Imagery;Impaired cognition;Individual;informal care;innovation;instrument;Insula of Reil;Intervention;Left;Link;Locomotion;Longevity;Magnetic Resonance Imaging;Modeling;modifiable risk;Motor;MRI Scans;neural;neuroimaging;offspring;older adult;Outcome;Parents;Participant;Pathway interactions;Persons;Prefrontal Cortex;processing speed;Quality of life;Research;Rest;Risk;Risk Factors;Risk Reduction;Role;Sensory;social contact;Social Network;social relationships;Social support;Societies;Stress Tests;Syndrome;Techniques;Testing;therapy development;Thick;Trail Making Test;Visit;Walking;white matter;Woman;Work

PROJECT_TITLE: Trajectories and modifiable risk factors of brain, gait, and cognitive decline in aging and pre-dementia

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Not applicable. 1

PI_NAMEs: ACHARYA, PRIYAMVADA ;CRISPIN, MAX ;DEKOSKY, BRANDON JAMES;HERSCHHORN, ALON  (contact)

PROGRAM_OFFICER_NAME: JANCI, ELIZABETH WONDERLICH

PROJECT_TERMS: Amino Acids;Antibodies;antibody libraries;Award;Binding;Biomedical Engineering;Biotechnology;Cell surface;Cells;Clinical Trials;combat;Data;Development;Directed Molecular Evolution;Engineering;Epitopes;Evolution;fitness;Glycoproteins;glycosylation;HIV resistance;HIV-1;improved;in vivo;innovative technologies;Knowledge;Libraries;Mammalian Cell;Masks;Membrane Glycoproteins;Molecular Conformation;neutralizing antibody;novel;Pattern;Penetration;Polysaccharides;Population;practical application;preventive intervention;Property;Prophylactic treatment;Resistance;resistance mechanism;resistant strain;screening;Site;Structure;Sum;synergism;transmission process;United States National Institutes of Health;Viral;Virus

PROJECT_TITLE: Dissecting the mechanisms of HIV resistance in vivo to broadly neutralizing antibodies


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Microbiome;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE This proposed research is relevant to public health because understanding the molecular mechanisms by which human microbiota, as well as microbial and host metabolites, contribute to oral cancer is expected to result in identification of biomarkers and potential targets for intervention. These findings are likely to be translated into novel and effective diagnostic and treatment options for patients with oral cancer and head and neck cancers, in general. The proposed research is relevant to the NIH mission to develop fundamental knowledge that will enhance health, lengthen life, and reduce illness and disability; in particular, our research pertains to understanding the causes, diagnosis, prevention, and cure of human diseases.

PI_NAMEs: FRANK, DANIEL N (contact);LU, SHI-LONG

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: 16S ribosomal RNA sequencing;Ablation;Acceleration;Activities of Daily Living;Address;Affect;Aftercare;Age;Alcohol consumption;Anatomy;Base Sequence;biomarker identification;Cell Line;Clinical Data;Complex;Data;Development;Diagnosis;Diagnostic;disability;Disease;disease prognosis;drinking;dysbiosis;effective therapy;Environment;Environmental Risk Factor;Exposure to;Genes;Germ-Free;Goals;Growth;Head and Neck Cancer;Health;HPV negative;Human;human disease;Human Microbiome;human microbiota;Human papilloma virus infection;Immunologics;improved;In Vitro;Incidence;Individual;innovation;insight;Integration Host Factors;Intervention;Knowledge;Life;Link;malignant mouth neoplasm;Malignant Neoplasms;Mediating;metabolome;metabolomics;metagenomic sequencing;Metagenomics;microbial;microbial genomics;microbiome;microbiota;Mission;Modeling;Molecular;molecular phenotype;Monitor;Morbidity - disease rate;mortality;mouse model;mouth squamous cell carcinoma;Mucous Membrane;Mus;Nitroquinolines;novel;novel marker;novel therapeutics;Oral;oral care;Oral cavity;oral microbial community;Oxides;Pathogenesis;Pathway interactions;Patients;Phenotype;Pre-Clinical Model;Prevention;prognostic;Property;Public Health;reconstitution;Research;Ribosomal RNA;Role;Saliva;Shapes;Shotguns;Smoking;Smoking History;Specimen;Staging;Study models;Taxonomy;Technology;Therapeutic;TNM;Tobacco;Translating;translational impact;Treatment Efficacy;tumor;tumor initiation;tumor progression;Tumor Promotion;tumorigenesis;United States National Institutes of Health

PROJECT_TITLE: Functional roles of the human microbiome and metabolome in oral cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: GH

IC_NAME: Center for Global Health

ORG_CITY: DHAKA

ORG_COUNTRY: BANGLADESH

ORG_FIPS: BG

ORG_NAME: INTERNATIONAL CTR/DIARRHOEAL DIS RES

PHR: Project Narrative (Relevance) Bangladesh is one of the most densely populated countries, both in terms of human and animal population. Despite attaining notable progress on most health indicators for the Sustainable Development Goals, Bangladesh has a high prevalence of a number of infectious diseases. Close living arrangements with animals and poultry, poverty, lack of regulations, poor infection control hygiene practices and inadequate resources, exacerbates the risk of emerging infections, making the country a hotspot for the emergence of a number of infectious diseases, including those with epidemic or pandemic potential. From early detection to intervention, we commit our efforts in various aspects of combating emerging infectious diseases. Our work spans epidemiology, virology, virus ecology, surveillance, risk analysis, prevention, and social and behavioral change. Our long-standing collaboration with the global partners provides the opportunity to foster the tracking of infections through hospital-based surveillance and population-based surveys in alliance with the Government of Bangladesh. Our research focuses on detection and response, building on our existing partnerships and surveillance capabilities and aims to provide important data for prioritizing emerging infections for public health intervention in Bangladesh. The proposed projects address important public health problems of Bangladesh, which will provide clinicians and policy makers with data to make public health decisions. Our surveillances support International Health Regulations (IHR), Global Influenza Surveillance and Response System (GISRS), global health security and global surveillances. Our laboratory capacity enabled us to study emerging infections and antimicrobial resistant pathogens. The integration of human, veterinary, and environmental sectors, as proposed by the `One Health' approach, in our research is expected to result in early warning of emerging infectious diseases and provide us with a better opportunity to respond to potential spillover threats.

PI_NAMEs: BANU, SAYERA  (contact)

PROJECT_TITLE: RFA-GH-24-033, Advancing Public Health Research in Bangladesh

STUDY_SECTION_NAME: Special Emphasis Panel[ZGH1 HMS (01)]


ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PI_NAMEs: PATTERSON, TOM  (contact)

PROJECT_TERMS: Contracts;Development;Evaluation;fungus;infectious disease model;mouse model;Mycoses;therapeutic evaluation;vaccine development

PROJECT_TITLE: Task A86: Therapeutics Testing in Murine Models of Fungal Infections


ORG_CITY: EAST SETAUKET

PHR: Development of treatments for neurological disorders

PI_NAMEs: ARALDI, GIAN  (contact)

PROJECT_TERMS: analytical method;assay development;authority;Biological Products;Chemicals;Chemistry;Clinical Research;Conduct Clinical Trials;Contracts;design;Development;Dose;Drug Kinetics;drug metabolism;Electronic Mail;Ensure;European;Experimental Designs;Feedback;Formulation;Guidelines;Human;International;Investigational Drugs;Lead;lead optimization;manufacture;Marketing;Medicine;member;method development;Methodology;Nervous System Disorder;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacy (field);Preparation;Process;product development;programs;Recommendation;Reporting;Research Contracts;Risk;Role;Science;Services;small molecule;Teleconferences;Telephone;therapy development;United States National Institutes of Health;Visit

PROJECT_TITLE: PHARMACEUTICS FORMULATION/CHEMISTRY MANUFACTURING AND CONTROL CONSULTING SERVICES FOR SMALL MOLECULES AND/OR BIOLOGICS


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: LOGAN

ORG_NAME: UTAH STATE UNIVERSITY

PI_NAMEs: HURST, BRETT  (contact)

PROJECT_TERMS: 2019-nCoV;Advanced Development;Anti-viral Agents;antimicrobial;Biological Assay;Cell Line;Contracts;Development;In Vitro;in vitro testing;Influenza Therapeutic;Maintenance;Middle East Respiratory Syndrome Coronavirus;respiratory virus;SARS coronavirus;Viral;Virus

PROJECT_TITLE: Task B19: In Vitro Assessment for Antimicrobial Activity Against Respiratory Viruses, SARS-CoV-2


NIH_SPENDING_CATS: Aging

ORG_CITY: WILMINGTON

ORG_NAME: CHARLES RIVER LABORATORIES INTNTL, INC.

PI_NAMEs: URIAS, SERGIO  (contact)

PROJECT_TERMS: Aging;Development;Maintenance;old mice

PROJECT_TITLE: DEVELOPMENT AND MAINTENANCE OF A MULTIGENOTYPIC AGED MOUSE COLONY


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Prevention;Substance Misuse

PHR: PROJECT NARRATIVE Sudden cardiac arrest (SCA) is a condition that is often fatal, and a proportion of these events occur in persons engaging in drug use. The proposed research uses established community-based studies to combine and analyze information about SCA related to drug use. This study will identify factors that may improve survival after SCA and identify combinations of circumstances that may prevent SCA events in this high-risk population.

PI_NAMEs: NORBY, FAYE  (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Address;Affect;Arrhythmia;Autopsy;Cardiac;Cardiovascular system;career development;Caring;Cessation of life;Clinical;Clinical Data;Cocaine;Communities;community setting;County;Data;data archive;Death Rate;design;Disparity;Drug Combinations;Drug usage;Elements;Epidemiology;Event;Exclusion;Familiarity;Frequencies;Funding;General Population;Goals;Grant;health record;Heart;Heart Arrest;high risk population;Home;Hypertrophic Cardiomyopathy;improved;Individual;Infrastructure;injury-related death;Investigative Reports;K-Series Research Career Programs;Knowledge;Lead;Location;Long QT Syndrome;Measures;Mental disorders;Mentored Research Scientist Development Award;Mentorship;Methods;mortality;Motivation;multimodality;National Heart, Lung, and Blood Institute;non-drug;non-opioid analgesic;novel;Opioid;opioid epidemic;out-of-hospital cardiac arrest;Overdose;overdose death;Peptide Initiation Factors;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Phenotype;Physiologic pulse;Plasma;polysubstance use;Population;prevent;Prevention;Prevention approach;programs;prospective;psychostimulant;Public Health;Publishing;Reaction Time;Records;Registries;Reporting;Research;Research Activity;Research Design;Research Personnel;Resources;response;Resuscitation;Series;skills;substance use;Sudden Death;survival prediction;Survival Rate;synthetic opioid;System;tool;Toxicology;Training;Training Activity;United States;Work

PROJECT_TITLE: Sudden Death Associated with Substance Use


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Hypertension;Neurodegenerative;Neurosciences;Prevention;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Vascular cognitive impairment/ dementia (VCID) occurs in up to 48% of stroke patients but has no FDA-approved treatment. Our research shows that VCID accumulates slowly after an experimental stroke and is preventable. With further research into the mechanisms and targets for intervention, this work has the potential to reduce the incidence of the second most common cause of dementia, VCID.

PI_NAMEs: ERGUL, ADVIYE  (contact)

PROJECT_TERMS: Address;aged;Agonist;antagonist;Astrocytes;Attenuated;autocrine;biological sex;Blood capillaries;Blood Vessels;Brain;brain endothelial cell;brain health;Caring;Cells;cerebrovascular;Clinical;Cognitive;Cognitive deficits;cognitive rehabilitation;comorbidity;Coupling;Creativeness;Cytometry;Data;Dementia;Development;diabetic;Disabling;Endothelial Cells;Endothelin;Endothelin-1;Endothelium;Equilibrium;experimental study;FDA approved;Female;functional improvement;Funding;Gliosis;Goals;Health;Human;Hypertension;hypertensive;hypoperfusion;Hypoxia;Image;imaging biomarker;Impaired cognition;improved;Incidence;innovation;Intervention;Ischemic Stroke;Knowledge;Liquid substance;Long-Term Care;male;Mesenchymal;Microglia;middle age;Molecular;Nature;Neurons;neurotoxic;paracrine;Pericytes;pharmacologic;phase III trial;Phenotype;Physical activity;post stroke;post stroke cognitive impairment;Pre-Clinical Model;preservation;prevent;Prevention;Prevention strategy;Preventive;psychologic;Rattus;receptor;Receptor Signaling;Recovery;Regulation;Research;Risk Factors;Role;senescence;Severities;sex;Signal Transduction;social;Social Problems;Societies;spatiotemporal;Stroke;stroke outcome;stroke patient;Stroke prevention;System;Testing;Therapeutic;therapeutic target;therapeutically effective;Vascular Cognitive Impairment;vascular risk factor;Work;Yin-Yang

PROJECT_TITLE: Progressive Post-Stroke Cognitive Impairment: Mechanisms & Intervention

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Our research centers on the repurposing of broadly available amines and carboxylic acids towards products that complement the classic amides produced with these two popular building blocks. This building block repurposing strategy is particularly valuable in drug discovery since the identification of novel catalysts and reaction conditions can enable the rational manipulation of physicochemical drug properties. The current proposal describes the accelerated discovery of such novel amine–acid methods through access to a modern ultra-performance liquid chromatography (UPLC) instrument with multiple chromatographic columns for rapid separation.

PI_NAMEs: CERNAK, TIMOTHY  (contact)

PROJECT_TITLE: Equipment Supplement: New Amine-Acid Couplings and their Impact on Medicinal Properties

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ORG_CITY: INDIANAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: PROJECT NARRATIVE OVERALL COMPONENT Alzheimer's disease is a major cause of death and disability in the United States and the National Alzheimer's Project Act seeks to identify a treatment or prevention for Alzheimer's disease (AD). In order to meet this ambitious goal, the interdisciplinary Indiana University/Jackson Laboratory/University of Pittsburgh (IU/JAX/PITT) MODEL-AD Center seeks to continue generating and characterizing novel animal models of AD, assessing the relevance of these to model to human disease, and developing a precision preclinical testing pipeline through which novel therapies can be tested to greatly accelerate the process by which therapies are successfully moved forward to human AD clinical trials. Importantly, the IU/JAX/PITT Center will generate new AD modeling processes and pipelines, data resources, research results and models that will be swiftly shared via existing infrastructure at the participating institutions and through the AD Knowledge Portal, academic medical centers, research institutions and the pharmaceutical industry worldwide.

PI_NAMEs: CARTER, GREGORY W;HOWELL, GARETH R;LAMB, BRUCE T (contact);OBLAK, ADRIAN LYNN;RIZZO, STACEY J;SASNER, MICHAEL ;TERRITO, PAUL RICHARD

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: Academic Medical Centers;Acceleration;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Animal Disease Models;Animal Model;Biological;Cause of Death;Cessation of life;Clinic;Clinical;Clinical Trials;Communities;Data;data modeling;data resource;data sharing;Dementia;Development;disability;Disease;disease model;Drug Industry;drug testing;Elderly;Functional disorder;Genetic;Genetic Models;Genetic Risk;genetic technology;genetic variant;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Human;human disease;imaging modality;imaging study;Indiana;Infrastructure;insight;Institution;International;Intervention;Knowledge Portal;Laboratories;Late Onset Alzheimer Disease;Mammalian Genetics;Medical;Mission;Modeling;Molecular;mouse model;multidisciplinary;Mus;Nerve Degeneration;neuroimaging;next generation;novel;novel therapeutics;Phenotype;pre-clinical;Preclinical Testing;prevent;Process;Prophylactic treatment;Protocols documentation;Research;Research Personnel;risk variant;screening;Testing;Therapeutic;tool;Translations;United States;Universities

PROJECT_TITLE: IU/JAX/PITT MODEL-AD Center: Prophylactic Treatment of Long acting GM-CSF (BBT-007) in B6.hAβsaa mice


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - C;Immunization;Immunotherapy;Infectious Diseases;Liver Disease;Vaccine Related

PHR: The role of functionally distinct hepatic T cell subsets in providing protective immunity from hepatotropic viruses, such as hepatitis C virus (HCV), or mediating liver pathology during inflammatory liver disease is poorly defined. Using a mouse model of an HCV-related virus we will investigate the functional properties and potential interplay of distinct type 1 and type 2 T cell and natural killer T (NKT) cell subsets during different stages of hepacivirus infection in vivo. Our results should reveal new concepts of hepatic T cell immunity with implications for the development of HCV vaccine strategies and new therapeutic options for liver disease.

PI_NAMEs: BILLERBECK, EVA  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acute;acute infection;Address;Adoptive Cell Transfers;Animal Model;Biological;Biology;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Chronic;Chronic Hepatitis C;chronic infection;chronic liver inflammation;Cirrhosis;comparison control;cytokine;Cytotoxic T-Lymphocytes;Data;Development;Disease Progression;end stage liver disease;Epitopes;Equilibrium;experimental study;Fibrosis;Flow Cytometry;Generations;Hepatic;Hepatitis B Virus;Hepatitis C;Hepatitis C Vaccination;Hepatitis C Vaccine;Hepatitis C virus;Hepatitis C-Like Viruses;Hepatocyte;high dimensionality;Human;Immune;Immune response;Immunity;Immunocompetent;Immunologics;Immunology;immunoregulation;Immunotherapeutic agent;in vivo;Infection;Inflammation;Inflammatory;innovation;insight;Interleukin-13;Interleukin-4;Kinetics;Knockout Mice;Link;Liver;Liver diseases;Liver Fibrosis;liver injury;Lymphocyte Subset;Mediating;Mediator;Memory;Metabolic stress;MHC Class I Genes;Modeling;mouse model;Mouse Strains;Mus;novel;novel therapeutics;Pathology;Patients;Phenotype;Play;polarized cell;Predisposition;Primary carcinoma of the liver cells;Property;Rattus norvegicus;repaired;response;restraint;Rodent;Role;Sampling;secondary infection;single-cell RNA sequencing;Steatohepatitis;T cell response;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Time;tissue repair;Tissues;Toxin;transcriptome;Translating;vaccination strategy;vaccine strategy;Viral;Viral hepatitis;Virus;Virus Diseases

PROJECT_TITLE: New insights into the functional diversity of the hepatic antiviral T cell response during hepacivirus infection in vivo

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Aging;Clinical Research;Complementary and Integrative Health;Nutrition;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Sarcopenia

ORG_CITY: BOSTON

ORG_NAME: HEBREW REHABILITATION CENTER FOR AGED

PHR: PROJECT NARRATIVE and Relevance to Public Health Our proposed work will estimate total body creatine pool size by D3-creatine dilution, a novel and previously validated method that provides a direct and accurate estimate of total muscle mass from a single, fasting urine sample. Our objective is to measure total muscle mass (via the D3-creatine dilution method) in the Framingham Heart Study (FHS) and determine its association with genetic and non-genetic risk factors, and their relation with falls, injurious falls and fractures in two large, community-based cohort of older adults, FHS and the Osteoporotic Fractures in Men (MrOS) Study, thus providing new and important public health insights.

PI_NAMEs: KIEL, DOUGLAS P. (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;Accelerometer;Age;age related;age-related muscle loss;Animals;Attenuated;Belief;Branched-Chain Amino Acids;Clinical;cohort;Cohort Studies;Communities;Creatine;Data;Diet;Dietary Proteins;disability;Dose;Dual-Energy X-Ray Absorptiometry;Essential Amino Acids;Excess Mortality;fall injury;falls;Fasting;Fracture;Framingham Heart Study;Genetic;genetic predictors;genetic variant;genome wide association study;Genotype;Goals;Health Care Costs;Image;imaging modality;Impairment;Inflammation;inflammatory marker;Ingestion;insight;instrument;Interleukin-6;Intervention;late life;Life Style;Measurement;Measures;Mediating;men;Mendelian randomization;Methods;Modeling;modifiable risk;Morphologic artifacts;muscle form;Muscular Atrophy;N-3 polyunsaturated fatty acid;non-genetic;novel;Nutritional;older adult;older men;older women;osteoporosis with pathological fracture;Outcome;Participant;Pathway interactions;Pharmaceutical Preparations;Physical activity;Physical Function;Plants;prevent;preventive intervention;Process;protein intake;Public Health;Publishing;reduced muscle mass;Research;Rest;Risk;Risk Factors;Sample Size;Sampling;skeletal muscle wasting;Specimen;systemic inflammatory response;Techniques;Technology;Testing;therapy development;Thinness;Tissues;Urine;Work

PROJECT_TITLE: Determinants and Outcomes of Age-related Muscle Loss

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Orphan Drug;Patient Safety;Pediatric;Pediatric - AIDS;Rare Diseases;Tuberculosis

ORG_CITY: Durban

ORG_NAME: CENTRE/AIDS PROGRAMME/RES/SOUTH AFRICA

PHR: Project Narrative: Integrase stand transfer inhibitors (InSTI), in particular dolutegravir and bictegravir, are potent, safe, well- tolerated drugs used for the treatment of HIV infection, but we do not yet fully know how to use them in patients with HIV and tuberculosis. Drug interactions with rifampicin, a key first-line tuberculosis drug, reduces exposures to these drugs and may reduce their efficacy, so we will therefore study whether increasing the doses of these drugs can overcome drug interactions and will be safe and effective for the treatment of HIV infection. Specifically, we will examine drug exposures, safety and efficacy of dolutegravir when given twice daily (double dose) to children (20-35kg) with HIV and TB on rifampicin to provide an evidence-base for the use of this drug in this subpopulation, and we will test twice-daily bictegravir/ /emtricitabine/tenofovir alafenamide (BIC/TAF/FTC) in adults with HIV taking tuberculosis treatment to ensure drug concentration and efficacy targets are met.

PI_NAMEs: DOOLEY, KELLY E.;NAIDOO, ANUSHKA  (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: ABCB1 gene;Adult;Africa;Africa South of the Sahara;antiretroviral therapy;Area;Child;Clinical;clinically relevant;co-infection;CYP3A4 gene;Data;Dedications;Diphosphates;Dose;Drug Exposure;Drug Interactions;Drug Kinetics;Drug usage;efavirenz;effective therapy;efficacy evaluation;emtricitabine;Enrollment;Ensure;Enzymes;Epidemic;evidence base;Exposure to;Film;Formulation;Fumarates;Future;Generations;Genetic;genetic testing;Goals;healthy volunteer;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;HIV-1;HIV/TB;Infection;inhibitor;Integrase;Investigation;Knowledge;Laboratories;Lamivudine;Measures;Medical;mortality;Patients;pediatrician;Persons;Pharmaceutical Preparations;phase III trial;pill;Plasma;Positioning Attribute;Price;Protease Inhibitor;Proteins;Publishing;Qualifying;Randomized;Recommendation;Regimen;Research;Resistance;Resistance development;Resource-limited setting;Rifampin;Safety;Sampling;South Africa;standard of care;Tablets;Tenofovir;Testing;Treatment Protocols;treatment research;Tuberculosis;tuberculosis drugs;tuberculosis treatment;UGT1A1 gene;Viral;Viral Load result;Weight;World Health Organization

PROJECT_TITLE: Second Generation InSTIs for the Treatment of HIV-1 in patients with TB co-infection on Rifampicin-based Treatment in KwaZulu Natal, South Africa


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Orphan Drug;Patient Safety;Rare Diseases;Tuberculosis

ORG_CITY: KANSAS CITY

ORG_NAME: MIDWEST RESEARCH INSTITUTE

ORG_STATE: MO

PHR: Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis (MTB), continues to be a significant public health burden and global threat. Ending the TB epidemic relies in great part on the early, accurate, and rapid diagnosis of MTB infection to facilitate screening and triage, improve case detection, and initiate effective treatment regimens. The primary purpose of the Mycobacterium tuberculosis Quality Assessment (TBQA) contract is to support and promote access to quality-assured MTB laboratory diagnosis and testing across laboratories participating in NIAID Division of AIDS (DAIDS)-supported clinical trials.

PI_NAMEs: OLINGER, GENE GARRARD (contact)

PROJECT_TERMS: accurate diagnosis;Acquired Immunodeficiency Syndrome;Adult;AIDS clinical trial group;Bacteria;Biological Assay;Brazil;Clinical;Clinical Research;Clinical Trials;Clinical Trials Network;cohort;Collaborations;Contracts;Data;data centers;Detection;Early Diagnosis;effective therapy;Enrollment;Ensure;Epidemic;HIV Vaccine Trials Network;improved;India;Individual;instrument;International Maternal Pediatric Adolescent AIDS Clinical Trials;Knowledge;Laboratories;Laboratory Diagnosis;Laboratory Study;Longitudinal Studies;Methodology;Monitor;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;Observational Study;Participant;Pharmaceutical Preparations;Play;primary endpoint;programs;prospective;Public Health;Quality Control;rapid diagnosis;Research;Role;safety study;screening;secondary endpoint;Site;Specific qualifier value;Test Result;Testing;Treatment Protocols;Triage;Tuberculosis;Validation

PROJECT_TITLE: Mycobacterium Tuberculosis (MTB) Quality Assessment Program (TBQA)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Stroke

ORG_CITY: LUBBOCK

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

PHR: PROJECT NARRATIVE Ischemic stroke and its associated post-stroke dementia are a major health problem in the United States. This project is proposed to investigate whether suppressing a transcription factor activity that facilitates cell death under the stroke condition reduces ischemic stroke-caused brain injury and neurological deficits. Moreover, we will also study how the transcription factor regulates nerve cell death and further test the therapeutic efficacy of identified drug candidates in the stroke animals.

PI_NAMEs: WANG, HONGMIN  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Affect;Alteplase;Alzheimer like pathology;Alzheimer's Disease;angiogenesis;Animals;Attenuated;Bioinformatics;Blood Vessels;Brain Diseases;Brain Injuries;Caenorhabditis elegans;Cell Death;Cell Death Induction;cell growth;Cell Nucleus;Cell Survival;Cells;Cerebral Ischemia;clinical translation;Clinical Trials;conditional knockout;Cytoplasm;Data;Dementia;Development;disability;DNA Binding;Down-Regulation;drug candidate;drug development;drug testing;Endothelial Cells;FDA approved;Female;fighting;FOXO1A gene;FOXO3A gene;functional disability;Gene Expression;Gene Modified;gene product;Genes;Genetic;Genetic Transcription;genome-wide;Growth Factor;Health;Homologous Gene;Inflammation;inhibitor;innovation;insight;Ischemia;Ischemic Stroke;Knock-out;Knockout Mice;Leucocytic infiltrate;Leukocytes;limb ischemia;Link;male;Mass Spectrum Analysis;Mediating;member;Microglia;mitochondrial dysfunction;MLLT7 gene;Molecular;mouse model;Mus;Myocardial Ischemia;neovascularization;neovasculature;Nerve Degeneration;Nervous System Disorder;neuroinflammation;Neurologic Deficit;neuron loss;Neuronal Injury;Neurons;neuroprotection;Neuroprotective Agents;new therapeutic target;Organic Chemistry;overexpression;Oxidative Stress;Oxidative Stress Induction;Pathologic;Pathway interactions;Peripheral;Pharmaceutical Preparations;pharmacologic;Phosphatidylinositols;Phosphorylation;Phosphotransferases;Physiological;post stroke dementia;Protein Family;Proteins;Proteomics;Reagent;Recovery of Function;Reperfusion Therapy;Role;sensor;Series;Stroke;structural biology;success;Temperature;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Time;Tissues;transcription factor;transcriptome;Translations;Treatment Efficacy;Tumor Suppressor Proteins;United States;Validation;Variant;Women's mortality;Work

PROJECT_TITLE: FOXOs in ischemic stroke

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: PPD DEVELOPMENT LP

PI_NAMEs: SMITH, KIMBERLY  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Clinical;Clinical Research;clinical research site;clinical trial implementation;Clinical Trials;Clinical Trials Network;Communication;Contractor;Contracts;Country;Data;Development;Ensure;Grant;Guidelines;HIV Infections;HIV therapy;HIV vaccine;HIV/AIDS;Medial;Modality;Monitor;National Institute of Allergy and Infectious Disease;operation;Performance;Pharmacy facility;Phase;Prevention Measures;Preventive;Procedures;Process;Protocols documentation;public health emergency;quality assurance;Quality Control;Recommendation;Records;remote interaction;Reporting;Research;Research Project Grants;Research Support;response;Safety;Services;Site;Site Visit;System;Treatment Efficacy;Vaccines;Visit;Writing

PROJECT_TITLE: NIAID Division of AIDS (DAIDS) Clinical Site Monitoring


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: NARRATIVE Funds are requested for partial support of the 2024 11th LASDB Conference to be held in the city of Valparaiso, Chile, in conjunction with the inaugural meeting of the recently created Chilean Society for Developmental Biology (SBDCh) and the first meeting in Latin America of the Pan-American Society for Evolutionary Developmental Biology (PASEDB). This Conference is intended to bring together a diverse group of scientists working on different aspects of Developmental Biology and using different experimental models and technological approaches to better understand the molecular and cellular processes controlling morphogenesis, providing a unique opportunity and format for the exchange of ideas and information and to attract/retain young postdocs and students to join this exciting research area. To provide more opportunities to early career investigators, postdocs and graduate students, we will select from the abstracts both short talks (15 mins) and flash talks (2.5 mins) to further motivate participation and interactions at the poster sessions, and will have a power hour session on career development, a meet-the-speaker session and several round tables / workshops sessions to debate topics of interests related to diversity in science, ethics, challenges of science in Latin America, developmental biology and climate change, outreach and teaching.

PI_NAMEs: OLIVER, GUILLERMO C (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Address;Amaze;American;Animal Model;Area;Argentina;base;Biodiversity;biophysical techniques;career;career development;Cell Physiology;Cells;Chile;Chilean;Cities;climate change;Collaborations;collaborative environment;Communities;comparative;Congresses;Country;Crows;Development;Developmental Biology;Developmental Process;Discipline;Disease;Educational process of instructing;Educational workshop;Embryology;Ensure;Environment;Equilibrium;Ethics;Ethnic Origin;Event;Evolution;experience;Experimental Models;Faculty;Feedback;Fostering;Funding;Funding Opportunities;Gender;Genes;Genetic;Genetic Complementation Test;Genetic Transcription;genomic platform;Goals;graduate student;Health;Hearing;Hour;Human;Imaging Techniques;In Vitro;in vivo;Influentials;interest;International;Laboratories;Latin America;Latin American;Learning;London;Measures;meetings;Microscopy;model organism;Modeling;Molecular;Morphogenesis;notch protein;novel;Optics;Organ;Organoids;outreach;pandemic disease;Participant;Pathway interactions;Postdoctoral Fellow;posters;Process;programs;Property;regenerative biology;Research;Research Personnel;Science;Scientist;self organization;Societies;Spain;stem cells;Student Selections;student training;Students;symposium;synergism;System;Technology;Time;Tissues;tool;training opportunity;Update;Variant;Woman

PROJECT_TITLE: 11th Latin American Society for Developmental Biology (LASDB) Conference

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Immunotherapy;Infectious Diseases;Microbiome;Pancreatic Cancer;Rare Diseases

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: Project Narrative: Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest cancer by 2030. We recently showed that TH2 cells produce type 2 cytokines (IL4 and IL13) that provide trophic support to PDAC tumorigenesis. In this proposal, we aim to understand the mycobiome mediated cancer cell-TH2 axis and explore the therapeutic potential of inhibiting this axis for PDAC treatment.

PI_NAMEs: DEY, PRASENJIT  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Agonist;anti-fungal agents;Antibodies;Aspergillus fumigatus;Baculoviruses;Binding;Binding Sites;Biological Assay;cancer cell;Candida albicans;CD4 Positive T Lymphocytes;Cell Line;Cell Nucleus;Cells;clinical development;Clinical Research;clinically relevant;Complex;Cryoelectron Microscopy;cytokine;Cytoplasm;Data;dectin 1;density;Development;Disease;Enzyme-Linked Immunosorbent Assay;Exocytosis;experience;fungus;Future;Genetically Engineered Mouse;IL4 gene;Image;Immune;Immune checkpoint inhibitor;Immune response;Immunofluorescence Immunologic;Immunologic Receptors;Immunoprecipitation;immunotherapy trials;in silico;In Vitro;Incubated;Infiltration;Inflammatory;insight;Interleukin-13;Kinetics;Ligation;Location;Lymphoid Cell;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Measures;Mediating;Mediator;Medical Research;microbial;Modeling;Molecular;Molecular Biology Techniques;Molecular Weight;Monoclonal Antibodies;mycobiome;neoplastic cell;neutralizing antibody;novel strategies;novel therapeutic intervention;nucleocytoplasmic transport;Organoids;overexpression;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pathogenic fungus;Pathway interactions;Patients;pharmacologic;Plasmid Cloning Vector;Play;Poly I-C;pre-clinical;Pre-Clinical Model;Production;Proliferating;protein purification;protein structure;Proteins;receptor;Regulation;Regulatory T-Lymphocyte;Research Institute;Role;Sampling;scale up;Serum;Signal Pathway;Signal Transduction;Sodium Chloride;Stimulus;Structure;Surface Plasmon Resonance;System;Techniques;Testing;Th2 Cells;Therapeutic;therapy resistant;Time;TLR1 gene;TLR2 gene;TLR3 gene;TLR4 gene;TLR5 gene;TLR6 gene;TLR7 gene;TLR8 gene;Toll-Like Receptor Pathway;Toll-like receptors;tumor;tumor growth;tumor microenvironment;Tumor-infiltrating immune cells;tumorigenesis;Universities;validation studies;Vesicle;Western Blotting;Work

PROJECT_TITLE: Role of type 2 immune response in pancreatic cancer tumorigenesis

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

PHR: PROJECT NARRATIVE In the absence of child welfare and similar social services in the sub-Saharan setting, extended family members, often older grandmothers (Bajjajja), frequently step forward and bear the crucial burden of caring for children whose parents have died or are otherwise affected by poor social determinants of health. Considering the resulting public health crises many sub-Saharan Africa countries would face without the safety net afforded by grandmother-caregivers, it is critical to address health outcomes and wellbeing of these older adults, who are already vulnerable to age-related poor health outcomes and chronic socioeconomic stressors that may be further exacerbated by caregiving. This study will use mixed methods and a community-informed approach to refine, adapt, and test BAJJAJJA (Building A Joint Action for JaJJAs), an innovative, multi-component intervention constituting of an income generating activity (IGA, facilitated by IGA experts) and health coaching (facilitated by visiting nurses).

PI_NAMEs: MATOVU, SCHOLA  (contact)

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Affect;Africa South of the Sahara;Age;age related;aged;Aging;Award;Behavior Therapy;behavioral clinical trial;Behavioral Model;Biometry;burden of illness;care burden;career development;Caregivers;caregiving;caregiving research;Caring;Cessation of life;Child;Child Care;Child Welfare;Chronic;cognitive interview;college;Communities;community engaged approach;community involvement;community partners;Country;Couples;Data;Dedications;design;Development;Discipline of Nursing;Disease;Economics;effective intervention;efficacy clinical trial;efficacy trial;Elderly;empowerment;Epidemic;experience;Extended Family;Face;family caregiving;Family member;feasibility testing;Feedback;Financial Hardship;Fogarty International Center;Frequencies;Funding;Future;Generations;Geriatric Nursing;Gerontology;global health;Goals;grandchild;grandparent;Health;health assessment;Health Disparities Research;health inequalities;Health Promotion;HIV/AIDS;Household;improved;Income;Individual;innovation;Intervention;Interview;Joints;Knowledge;Leadership;life span;Literature;Longevity;Maintenance;marginalization;maternal condition;Measures;member;Mentored Research Scientist Development Award;Mentors;Methodology;Methods;mortality;multi-component intervention;novel;Nurses;older adult;Orphan;Outcome;Parents;Participant;Perinatal;Personal Satisfaction;Persons;Physical activity;poor health outcome;Population;Positioning Attribute;post intervention;Poverty;Primary Care;primary caregiver;Process;professor;Psyche structure;psychosocial;Public Health;Quality of life;Quasi-experiment;Research;Research Methodology;Research Personnel;Research Priority;research study;Research Training;Resource-limited setting;Resources;Risk;Role;Rural;safety net;Science;Series;Site Visit;skills;social health determinants;Social Protection;Social Work;socioeconomics;stressor;Testing;therapy development;Time;Training;Training Programs;Treatment Efficacy;Uganda;United States National Institutes of Health;Universities;Utah;Vision;Visiting Nurse;War;Woman

PROJECT_TITLE: Development and Testing of BAJJAJJA: An Intervention to Promote Economic Empowerment and Health of Grandmothers who Provide Primary Care for Grandchildren in Uganda

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICP-W (55)]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Mental Health;Neurosciences;Pediatric

ORG_CITY: Charlestown

ORG_NAME: MGH INSTITUTE OF HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE This project examines behavioral and neurocognitive correlates of reading to differentiate contributions of executive function (EF) weaknesses from ADHD status in dyslexia. Using a longitudinal design, this research aims to (1) bring a novel understanding of how ADHD diagnosis and EF weaknesses impact behavioral and neurocognitive reading growth among students with dyslexia, (2) offer a novel test of the Multiple Deficit Model, (3) offer novel data on EF brain networks in dyslexia, (4) and inform approaches for assessment and intervention for struggling readers. Our discovery of behavioral and neurocognitive reading growth will offer the largest and longest study of dyslexia to date, with insights as to whether EF or ADHD status may prevent some students with dyslexia from closing gaps in reading performance.

PI_NAMEs: CHRISTODOULOU, JOANNA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Affect;Age;Attention deficit hyperactivity disorder;behavior measurement;Behavioral;Brain;Child;clinical diagnosis;comorbidity;Corpus striatum structure;Data;Data Collection;data quality;Data Set;Development;Developmental reading disorder;Diagnosis;Diagnostic;diagnostic criteria;Disease;DSM-V;Dyslexia;Etiology;Exclusion;Executive Dysfunction;executive function;Exhibits;Functional Magnetic Resonance Imaging;Growth;Heterogeneity;improved;indexing;Inferior frontal gyrus;insight;Intervention;Lateral;Left;longitudinal design;Magnetic Resonance Imaging;Measures;meetings;Mission;Modeling;National Institute of Child Health and Human Development;Neurocognitive;Neurodevelopmental Disorder;neuroimaging;novel;Occipital lobe;Outcome;Participant;peer;Performance;prevent;Reader;Reading;reading difficulties;Recording of previous events;recruit;Reporting;Research;Research Design;Sampling;skills;Structure of middle temporal gyrus;Students;Superior temporal gyrus;Surveys;symptomatology;Testing;Theoretical model;theories;Time;Variant;Visit;Work

PROJECT_TITLE: Influence of ADHD and Executive Functions on Developmental Dyslexia

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: The proposed research is relevant to addiction research because understanding the reach and effectiveness as well as the accessibility and acceptability of harm reduction vending machines (HRVMs) dispensing naloxone and other harm reduction supplies, especially among persons with limited opportunity structures. Together with the parent grant, this proposal is expected to demonstrate the impact of low-threshold harm reduction approaches, like HRVMs, in increasing equitable access to harm reduction supplies, including naloxone. Thus, this proposed research is relevant to the part of NIDA’s mission that pertains to supporting research to evaluate the efficacy of harm reduction approaches to address the current drug crisis.

PI_NAMEs: DAVIDSON, PETER JOHN (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: addiction;Address;Affect;Black American;Black race;Characteristics;Communities;community setting;Computer software;Cross-Sectional Studies;Data;Development;Drug user;Effectiveness;efficacy evaluation;Equity;ethnic minority;Event;evidence base;experience;Frequencies;Goals;Harm Reduction;Health;high risk;Homelessness;improved;Individual;Interview;Justice;Latinx;Logistic Regressions;Methods;Mission;Morbidity - disease rate;mortality;Naloxone;naloxone dispensing;National Institute of Drug Abuse;Opioid;opioid overdose;Outcome;Overdose;parent grant;Parents;Participant;Perception;Persons;Pharmaceutical Preparations;Population;programs;racial minority;recruit;Reduce health disparities;Regression Analysis;Research;Research Personnel;Research Support;Resources;Role;Services;Structure;Testing;Work

PROJECT_TITLE: Exploring the accessibility, acceptability, and utilization of a community-based harm reduction vending machine among persons with limited opportunity structures.

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]