NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

PROJECT_TERMS: Behavioral Research;Biomedical Research;Clinical Research;Clinical Trials Network;Helping to End Addiction Long-term;improved;Longitudinal Studies;National Institute of Drug Abuse;Opiate Addiction;Opioid;opioid misuse;Public Health;Research;Resources;Services;Speed;Support Contracts;United States National Institutes of Health;Work

PROJECT_TITLE: TO PROVIDE BIO-MEDICAL AND BEHAVIORAL RESEARCH RESOURCES AND CLINICAL RESEARCH COORDINATING SERVICES TO SUPPORT THE NIDA CLINICAL TRIALS NETWORK (CTN) HEAL STUDIES. POP 2/26/24 - 8/25/24


ADMINISTERING_IC: DA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: ROCKVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: THE EMMES COMPANY, LLC

ORG_STATE: MD

PI_NAMEs: MCCORMACK, JENNIFER  (contact)

PROJECT_TERMS: Helping to End Addiction Long-term;Hospitals;improved;Opiate Addiction;Opioid;opioid misuse;Public Health;Research;Speed;Support Contracts;United States National Institutes of Health;Work

PROJECT_TITLE: EXEMPLAR HOSPITAL INITIATION TRIAL TO ENHANCE TREATMENT ENGAGEMENT (CTN-0098). JUNE 10, 2024 TO NOVEMBER 1, 2026. N01DA-22-2253. TASK ORDER NO. 75N95024F00003 (TO19).


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE: Glioblastoma (GBM) is lethal brain tumor with a median survival of 15 months. Therefore novel therapy is urgently needed. Following analysis of data from The Cancer Genome Atlas, and subsequent experimental validation studies, we have identified a subgroup of GBM patients who can be treated with a novel combination of a specific drug and a research diet. We expect that our studies will shed new insights into a novel glioblastoma therapy.

PI_NAMEs: DASGUPTA, BIPLAB  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: 1p36;Ablation;Acids;acquired drug resistance;Address;Algorithms;Alleles;Analytical Chemistry;Atlases;biological adaptation to stress;Biological Availability;Biological Markers;Biology;blood-brain barrier crossing;Brain Mass;Brain Neoplasms;cancer cell;Cancer Etiology;CDKN2A gene;cell growth;Cell Line;Cell Survival;Cells;Chromosome 10;chromosome 1p loss;Chromosomes;Classification;classification trees;Clinical Trials;Collaborations;Combined Modality Therapy;CRISPR/Cas technology;Culture Media;Custom;Data;Data Analyses;Data Set;Databases;Diet;Diet Research;Diet therapy;dietary;Dietary Component;Dose;Down-Regulation;driver mutation;drug sensitivity;efficacy evaluation;endoplasmic reticulum stress;enolase;Environmental Risk Factor;Enzyme Inhibitor Drugs;Enzymes;Epidermal Growth Factor Receptor;Etiology;Event;experience;experimental study;Fatty Acids;Feasibility Studies;FRAP1 gene;Gene Deletion;Genes;Genetic;Glioblastoma;Glioma;Goals;Growth;Human;Hypersensitivity;in vivo;inhibitor;inhibitor therapy;insight;Lesion;Lipids;loss of function;Malignant neoplasm of prostate;Malignant Neoplasms;Maximum Tolerated Dose;Medicine;Melanoma;Melanoma Cell;Membrane Fluidity;Messenger RNA;metabolomics;Methods;Methylation;Molecular;Monounsaturated Fatty Acids;mouse model;mTOR Inhibitor;Mus;Mutation;novel;novel therapeutics;Oleates;Oleic Acids;Oncogenes;Oral;overexpression;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacology;PI3K/AKT;PIK3CG gene;Plant Oils;Point Mutation;pre-clinical;preclinical study;Proliferating;Proteins;Proto-Oncogene Proteins c-akt;PTEN gene;Reducing diet;Refractory;Regimen;regression trees;Research;Residual state;Resistance;Resistance development;RNA Polymerase II;Signal Transduction;Specificity;statistics;Stearoyl-CoA Desaturase;stem cells;Stress;Subgroup;targeted cancer therapy;Testing;The Cancer Genome Atlas;Therapeutic;TP53 gene;treatment response;tumor;tumor growth;Tumor Suppressor Genes;Tumor Suppressor Proteins;Up-Regulation;Validation;validation studies

PROJECT_TITLE: Bystander gene deletions in cancer: mechanisms of therapeutic opportunities and challenges

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


PROJECT_TERMS: Contracts;Helping to End Addiction Long-term;improved;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;Public Health;Research;Speed;United States National Institutes of Health

PROJECT_TITLE: HEAL MANAGEMENT AND SUPPORT. AUGUST 2, 2024 TO AUGUST 1, 2025. N01DA-22-2253. TASK ORDER NO. 75N95024F00005 (TO21).


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Rural Health;Social Determinants of Health;Substance Misuse

PROJECT_TERMS: Helping to End Addiction Long-term;improved;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid use disorder;Pharmaceutical Preparations;Public Health;Research;Rural;Speed;Support Contracts;United States National Institutes of Health;Work

PROJECT_TITLE: RURAL EXPANSION OF MEDICATION TREATMENT FOR OPIOID USE DISORDER (CTN-0102). AUGUST 1, 2024 TO MARCH 31, 2026. N01DA-22-2253. TASK ORDER NO. 75N95024F00008 (TO24).


PI_NAMEs: JELSTROM, EVE  (contact)

PROJECT_TERMS: Clinical;Clinical Trials Network;Helping to End Addiction Long-term;improved;National Institute of Drug Abuse;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;Public Health;Research;Speed;Support Contracts;United States National Institutes of Health;Work

PROJECT_TITLE: CTN HEAL ENHANCEMENT. CLINICAL COORDINATING CENTER FOR NIDA'S CLINICAL TRIALS NETWORK. TO2. POP: 8/15/24 - 11/1/2026


PROJECT_TITLE: CLINICAL COORDINATING CENTER FOR NIDA'S CLINICAL TRIALS NETWORK.  CTN PORTFOLIO SUPPORT (NON-HEAL). 8/15/24 - 8/14/25


NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD);Rare Diseases

ORG_CITY: FAIRFAX

ORG_NAME: ICF, INC., LLC

ORG_STATE: VA

PI_NAMEs: SAULS, KATE  (contact)

PROJECT_TERMS: Advocacy;Clinical Research;Communities;Disease;experience;Family;genetic counselor;Genetic Diseases;Hand;Health Professional;Information Centers;Information Specialists;member;National Center for Advancing Translational Sciences;National Human Genome Research Institute;Nurses;Occupational Therapist;Patients;Persons;physical therapist;Physicians;programs;Rare Diseases;Research;Research Support;Resources;Scientist;Social Workers;Spanish/English;teacher;United States National Institutes of Health;virtual;Work;Writing

PROJECT_TITLE: MANAGEMENT AND RESEARCH SUPPORT FOR THE GENETIC AND RARE DISEASES (GARD) INFORMATION CENTER AND RELATED PROGRAMS


NIH_SPENDING_CATS: Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: DENVER

ORG_NAME: PALANTIR TECHNOLOGIES, INC.

ORG_STATE: CO

PI_NAMEs: MARIZAN-HO, JOHANNA  (contact)

PROJECT_TERMS: Advisory Committees;Award;Clinical;Clinical and Translational Science Awards;Clinical Data;Clinical Research;cloud based;cohort;Collaborations;COVID-19;Data;Data Aggregation;Data Analytics;data de-identification;data enclave;Data Set;Dedications;Development;Environment;Institution;member;National Center for Advancing Translational Sciences;National Institute of General Medical Sciences;Personally Identifiable Information;Persons;privacy protection;programs;Research;Secure;synthetic data;Translational Research;United States National Institutes of Health

PROJECT_TITLE: SECURE PLATFORMS SUPPORT FOR THE N3C, NIDAP, AND ASPIRE


ORG_CITY: ALBUQUERQUE

ORG_NAME: LOVELACE BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: NM

PI_NAMEs: ROBERTSON, MIKE  (contact)

PROJECT_TERMS: Biodistribution;Miniature Swine

PROJECT_TITLE: BIOANALYTICAL SUPPORTS FOR A GLP TOX/BIODISTRIBUTION STUDY IN MINI-PIGS


PI_NAMEs: ZAVERTNIK, BRIAN  (contact)

PROJECT_TITLE: NCATS: SECURE PLATFORMS SUPPORT FOR THE N3C, NIDAP, AND ASPR


PROJECT_TITLE: SECURE PLATFORMS SUPPORT FOR THE N3C DATA ENCLAVE


NIH_SPENDING_CATS: Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Advisory Committees;Award;Clinical;Clinical and Translational Science Awards;Clinical Data;Clinical Research;cloud based;cohort;Collaborations;COVID-19;Data;Data Aggregation;Data Analytics;data de-identification;data enclave;Data Set;Dedications;Development;Electronics;Environment;Institution;member;National Center for Advancing Translational Sciences;National Institute of General Medical Sciences;Personally Identifiable Information;Persons;privacy protection;programs;Research;Secure;synthetic data;Translational Research;United States National Institutes of Health

PROJECT_TITLE: NIDAP ELECTRONIC SCIENTIFIC REVIEW ASSISTANCE (ESRA) APPLICATION SUPPORT


ORG_CITY: SAN DIEGO

ORG_NAME: IRISYS, INC.

ORG_STATE: CA

PI_NAMEs: BOURQUE, TIM  (contact)

PROJECT_TERMS: Development;Dosage Forms;manufacture;Phase II Clinical Trials

PROJECT_TITLE: THIS TASK ORDER (TO) IS TO PROVIDE DOSAGE FORM DEVELOPMENT, MANUFACTURE AND STABILITY STUDIES OF ORC-13661 FOR PHASE II CLINICAL TRIAL


NIH_SPENDING_CATS: Clinical Research;Coronaviruses;Emerging Infectious Diseases;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: BETHESDA

PI_NAMEs: BACKUS, MARK  (contact)

PROJECT_TERMS: analytical tool;Award;Businesses;Clinical and Translational Science Awards;Clinical Research;cloud based;cohort;Communities;Complex Analysis;Contracts;COVID-19;cyber security;Data;data enclave;Development;Electronic Health Record;Environment;genetic variant;Genomics;Image;Information Technology;Ingestion;Institution;meetings;multimodal data;National Center for Advancing Translational Sciences;National Institute of General Medical Sciences;open source;Pathology;Privacy;Productivity;programs;Radiology Specialty;Research;Research Personnel;Secure;Security;service programs;Services;synthetic data;tool;Translational Research;United States National Institutes of Health;Viral;virtual;Work

PROJECT_TITLE: NCATS CYBERSECURITY SERVICES PROGRAM SUPPORT. POP: 07/29/2024 - 09/18/2024.


NIH_SPENDING_CATS: Clinical Research;Coronaviruses;Data Science;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: NORTH BETHESDA

ORG_NAME: AXLE INFORMATICS, LLC

PI_NAMEs: MAYS, GARY  (contact)

PROJECT_TERMS: analytical tool;Area;Award;Clinical and Translational Science Awards;Clinical Research;cloud based;cohort;Collaborations;Communities;Complex Analysis;Contracts;COVID-19;COVID-19 patient;Data;Data Analyses;Data Collection;data enclave;data harmonization;data platform;Data Science;Data Set;Development;Electronic Health Record;Environment;genetic variant;Genomics;Health;Image;Informatics;Information Technology;Ingestion;Institution;meetings;multimodal data;National Center for Advancing Translational Sciences;National Institute of General Medical Sciences;open source;open source tool;Pathology;Privacy;Productivity;programs;protective factors;Pythons;Radiology Specialty;Research;Research Personnel;Risk Factors;Scientist;Secure;Security;Services;Statistical Data Interpretation;synthetic data;tool;Translational Research;United States;United States National Institutes of Health;Viral;virtual;Visualization;Work

PROJECT_TITLE: TASK ORDER 7 - ODP


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: WASHINGTON

ORG_STATE: DC

PROJECT_TITLE: NHLBI WORKSHOP/CONFERENCE SUPPORT


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: TORRANCE

PI_NAMEs: PORTER, KEITH  (contact)

PROJECT_TERMS: Bacterial Artificial Chromosomes;Coenzyme A;Pharmaceutical Preparations;Reference Standards;Testing

PROJECT_TITLE: HAVE BACHEM ISSUE QA REVIEWED COAS OF GMP DRUG SUBSTANCE PTH-IA AND ITS QUALITATIVE REFERENCE STANDARD AND ASSIGN A NEW RETEST DATE BASED ON THE STABILITY STUDY RESULTS. ANOTHER PURPOSE IS TO HAVE BAC


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

PROJECT_TITLE: OFFICE OF COMPUTER AND COMMUNICATIONS SYSTEMS (OCCS) IT TECHNICAL SUPPORT - ICF.


NIH_SPENDING_CATS: Clinical Research;Health Services;Women's Health Research

ORG_CITY: MCLEAN

PROJECT_TERMS: Collaborations;Communication;Computers;Data;Development;Funding;Grant;Information Technology;Infrastructure;Investments;Literature;Phase;Public Health;Research;Services;System;Terminology;tool development;United States National Institutes of Health;United States National Library of Medicine;Women's Health;Women's Health Services

PROJECT_TITLE: INFORMATION TECHNOLOGY SERVICES FOR CONSUMER/PUBLIC HEALTH AND TERMINOLOGY APPLICATIONS FOR THE NATIONAL LIBRARY OF MEDICINE'S (NLM) OFFICE OF COMPUTER AND COMMUNICATIONS SYSTEMS (OCCS)


ORG_CITY: LANHAM

ORG_NAME: SOFTWARE CONSULTANTS, INC.

PROJECT_TITLE: TECHNICAL SUPPORT FOR DISCOVERY SERVICE FOR WOMEN'S HEALTH RESEARCH


PROJECT_TITLE: DISCOVER WOMENS HEALTH RESEARCH (DISCOVERWHR) COORDINATION AND CONTENT SUPPORT


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: TUCSON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE Colorectal cancer screening among Latinx populations lags far behind that of non-Latinx White populations. We will test a program that pairs video-texting with neighborhood navigation services to improve colorectal cancer screening for adults who are new to screening or have never been screened. Our program could serve as a model for sharing accurate health information and promoting healthy behavior for a variety of diseases.

PI_NAMEs: CORONADO, GLORIA D (contact);ESCARON, ANNE LAURE

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TITLE: Community Partnership for Telehealth Solutions to Counter Misinformation and Achieve Equity (PRIME)


NIH_SPENDING_CATS: Precision Medicine

PI_NAMEs: MCDOUGALL, ALLIE  (contact)

PROJECT_TERMS: All of Us Research Program;Awareness;community engagement;Community Health Education;Contracts;Libraries;Participant;Positioning Attribute;Precision Medicine Initiative;Program Evaluation;programs;Support Contracts;United States;United States National Institutes of Health;United States National Library of Medicine

PROJECT_TITLE: USER ENGAGEMENT PROGRAM SUPPORT TASK ORDER


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: IOWA CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Molecular chaperones maintain protein homeostasis in cells by facilitating protein folding, translocation, and degradation. They exist in multiprotein complexes to regulate cellular processes such as cell signaling, DNA repair, and more recently, cell metabolism. The proposed studies aim to understand how these chaperone complexes recruit and act on metabolic enzymes to meet the increased demand brought on by reprogramming events that contribute to human disease progression.

PI_NAMEs: PEDLEY, ANTHONY M (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TITLE: Molecular Chaperone-mediated Regulated of Cell Metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: MILLBRAE

ORG_NAME: FRIENDI.FI CORPORATION

PHR: Narrative  Delirium, a major cause of falls, can occur in as many as 50% of cancer patients undergoing stem cell transplant,  resulting in up to 14 times greater chance of dying. Delirium risk can be mitigated and many other outcomes of  stem cell transplants can be improved through behavioral interventions delivered at the bedside through  conversation, imagery, and audio. care.coach™ is developing a technology-enabled cancer care platform that  provides 24x7 proactive bedside support for patients undergoing stem cell transplants, to mitigate delirium and  falls while improving recovery through better adherence to diet, exercise, and other best practices, in a scalable,  cost-effective manner.

PI_NAMEs: WANG, VICTOR  (contact)

PROGRAM_OFFICER_NAME: WEBER, PATRICIA A

PROJECT_TITLE: A Bedside Relational Agent to Improve Hematopoietic Cell Transplantation Outcomes in Cancer Patients


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative More than 9 in 10 individuals carrying a penicillin allergy label are not truly allergic, which has widespread consequences that include a higher risk of antibiotic-resistant bacteria. Removal of inaccurate penicillin allergy labels (de-labeling) is a safe and recommended strategy to improve antibiotic prescribing. This project seeks to measure, understand, and improve equitable access to penicillin allergy de-labeling.

PI_NAMEs: BLUMENTHAL, KIMBERLY GOLD (contact);WURCEL, ALYSSE GAIL

PROGRAM_OFFICER_NAME: LIN, LEYI

PROJECT_TITLE: Improving Equitable Access to Penicillin Allergy De-Labeling

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative The burden of hypertension and related cardiovascular disease, stroke, and end-stage kidney disease is disproportionally high in Black populations, especially in the South. This cluster randomized trial will test the effectiveness, implementation, and sustainability of a church wellness coordinator-led multifaceted intervention compared to enhanced usual care on hypertension control in Black communities. This study will generate evidence on an effective, scalable, and sustainable strategy for eliminating hypertension disparities in Black communities.

PI_NAMEs: HE, JIANG  (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TITLE: Church Wellness Coordinator-led Intervention to Improve Hypertension Control in the Black Community


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Alzheimer's Disease affects about 6 million people in the United States, every minute one American develops Alzheimer’s Disease. APOE4 is the major genetic cause of Alzheimer’s Disease, more than 60% of the patients have one copy of APOE4 yet this genetic knowledge has not been translated to treatment. Leveraging our recent discovery of an enhancer RNA that regulates APOE expression, this project delves into this regulatory relationship and the function of APOE to set the stage for precision Alzheimer's Disease treatment.

PI_NAMEs: CHEUNG, VIVIAN G (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TITLE: A comprehensive study of APOE and the noncoding RNA AANCR to advance Alzheimer’s Disease treatment

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PI_NAMEs: STANCILL, JENNIFER SUSAN (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TITLE: Peroxiredoxin 1 in pancreatic beta-cells


ORG_CITY: NEW HAVEN

ORG_DEPT: UROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The resistance to current AR targeted therapies is one of the biggest challenges when treating advanced prostate cancer and largely hinders the clinical outcome of patients with this deadly disease. This study aims to determine the molecular role of a new potential tumor suppressor in prostate cancer, SYNCRIP, in suppressing APOBEC- mediating mutagenesis and resistance to AR targeted therapies. Elucidating the role of this protein and the molecular mechanism of the resistance may identify new actionable targets and establish a pathway for the development of therapeutic approaches to overcome the resistance and ultimately benefit patients.

PI_NAMEs: MU, PING  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: advanced prostate cancer;Affect;American;androgen independent prostate cancer;apoB mRNA editing catalytic subunit;Apoptosis;Automobile Driving;Binding;cancer diagnosis;cancer initiation;Cancer Patient;Castration;Cell Proliferation;Cells;Clinical;Cytoplasm;Data;Deaminase;Dependence;Disease;DNA;DNA Sequence Alteration;enzalutamide;Genes;genetic testing;Genetically Engineered Mouse;Genomics;Human;Impairment;improved;In Vitro;in vitro Model;in vivo;insight;knock-down;Knock-out;Libraries;Malignant neoplasm of prostate;Mediating;men;Messenger RNA;Molecular;mouse model;Mus;Mutagenesis;Mutate;neoplastic cell;novel;Oncogenes;Oncogenic;Organoids;Outcome;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;prostate cancer cell;prostate cancer cell line;prostate cancer model;Proteins;Reporting;Resistance;resistance mechanism;Resolution;response;RNA-Protein Interaction;Role;screening;senescence;Signal Pathway;synaptotagmin;targeted treatment;therapeutic development;therapeutic target;therapy resistant;treatment response;tumor;tumor growth;tumor heterogeneity;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenesis;Work;Xenograft Model

PROJECT_TITLE: Elucidating the Molecular Role of SYNCRIP in Prostate Cancer and AR Targeted Therapy Resistance

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BALTIMORE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE Host innate immune response plays a crucial role in combating a large number of viral infections. This proposal focuses on the protein OAS1, which is produced during the early part of the host response and helps shape the later adaptive response to clear viral infections. We have discovered that the OAS1 protein uniquely controls the host immune response to virus infections, including against flaviviruses such as West Nile virus. When completed, our studies should create a new paradigm for understanding how OAS1 functions to inhibit viruses.

PI_NAMEs: DIAMOND, MICHAEL S;SARKAR, SAUMENDRA N (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: 3' Splice Site;adaptive immune response;adaptive immunity;Affect;Alleles;Alternative Splicing;Anti-viral resistance;antiviral drug development;Automobile Driving;Binding;Biochemical;Biological Assay;C-terminal;cell type;Cells;Cellular biology;cellular targeting;Code;Data;Diamond;DNA Viruses;Event;experimental study;Family;Family member;Flavivirus;Genes;Genetic Polymorphism;Goals;Grant;Hematopoietic;Host Defense;Human;Human Genome;Immune response;In Vitro;in vivo;Infection;Innate Immune Response;Interferon Type I;Interferons;IRF1 gene;Knock-in Mouse;knockout gene;Knowledge;Laboratories;Laboratory mice;Length;Ligase;loss of function;Maps;Mediating;Mediator;member;Messenger RNA;Molecular;mouse genome;Mus;Mutate;Natural Immunity;Nature;Nucleic Acids;oligoadenylate;Organ;Orthologous Gene;Play;Predisposition;promoter;Property;protein expression;Protein Family;Protein Isoforms;Protein Synthesis Inhibition;Protein Truncation;Proteins;Proteomics;Reporter;response;Ribonucleases;RNA immunoprecipitation sequencing;RNA Viruses;Role;Scheme;Severity of illness;Shapes;Signal Transduction;Site;T-Lymphocyte;Terminator Codon;Testing;Therapeutic;Transferase;Translational Regulation;Translations;Untranslated Regions;Up-Regulation;Vaccinia virus;Viral;Viral Pathogenesis;Viral Physiology;Viral Proteins;Virus;Virus Diseases;Virus Replication;West Nile viral infection;West Nile virus

PROJECT_TITLE: A new mechanism of antiviral activity of 2-5 Oligoadenylate Synthetase 1

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative  Patients who have received joint replacement are at risk for periprosthetic joint infection, a serious condition which can lead to morbidity, disability, amputation, and even death. We will investigate how an injectable biomaterials-based vaccine system improves host immunity to prevent Staphylococcus aureus periprosthetic joint infection in a murine model. This project will lead to a better understanding of immunity in device-related infection and characterize a new vaccine modality.

PI_NAMEs: TATARA, ALEXANDER MITCHELL (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TITLE: Biomaterials-based Immunoengineering for Periprosthetic Joint Infection

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PI_NAMEs: MOHRIN, MARY  (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Acute Myelocytic Leukemia;Age;age-related disease;aged;Aging;biological adaptation to stress;Cancer Center;Cardiovascular Diseases;Cells;Cellular Stress;Chronology;Clone Cells;Defect;Disease;Fatty Liver;Hematopoiesis;Hematopoietic stem cells;Hematopoietic System;Human;Immune;Immunologic Surveillance;Infiltration;Kentucky;Knockout Mice;Longevity;Mitochondria;Myelogenous;Myocardial dysfunction;Pathway interactions;Peripheral;Preleukemia;Quality Control;Regulation;residence;response;Risk;Tissues;Touch sensation;tumor metabolism;Universities

PROJECT_TITLE: Targeting SIRT7 Regulation of Mitochondrial Quality Control to Short Circuit Age-Related Diseases of the Hematopoietic System


ORG_CITY: LINCOLN

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PI_NAMEs: TANG, QING  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Actin-Binding Protein;Actins;Active Biological Transport;Architecture;Binding;Biogenesis;cancer cell;Cell Communication;Cells;Cellular biology;Cellular Structures;cofilin;Communication;Crosslinker;Cytoskeleton;density;Disease;F-Actin;fascin;Filament;Goals;Human;Human Pathology;Immune;Impairment;innovation;intercellular communication;Intervention;Ions;Maintenance;Maps;Membrane;Methods;Microfilaments;Microscopy;Mitochondria;Modeling;Molecular;Molecular Biology;Molecular Motors;Morphogenesis;Movement;Myosin ATPase;Myosin Type V;Nanotubes;Nebraska;Organelles;Pathology;Pathway interactions;pharmacologic;Physiology;Population;predictive modeling;Process;protein aggregation;Protein Chemistry;Proteins;Role;Side;Signal Transduction;single molecule;small molecule;spatiotemporal;stem;Structure;superresolution microscopy;System;Technology;Testing;Theft;Therapeutic;Thinness;Tropomyosin;Tube;ultra high resolution;vasodilator-stimulated phosphoprotein;Vesicle;Virus

PROJECT_TITLE: Mechanisms of tunneling nanotube architecture and function


ORG_CITY: NEW ORLEANS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE The goal of these studies is to understand how sensory nerves in the skin regulate immune cell function during skin penetration by parasitic worms found in contaminated water. We think that protective immunity against these worms may be dependent on interactions between itch-specific nerves and immune cells in the skin, but this has not been studied before. The proposed experiments may uncover a therapeutic means to prevent skin penetration, which does not currently exist.

PI_NAMEs: HERBERT, DE'BROSKI R (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TITLE: Neuro-Immune mechanisms against skin-penetrating helminths


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Frequency modulations are crucial to our ability to communicate via speech and music. This research will provide insights into how frequency modulation is represented in the normal-hearing human auditory system across the adult lifespan. These findings will be an important first step towards revealing how the coding of frequency modulation changes with both age and hearing loss and will help guide future interventions to improve communications for people with hearing difficulties.

PI_NAMEs: WHITEFORD, KELLY L (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TITLE: Neural and Perceptual Mechanisms for Coding Frequency Modulation

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: The formation of the distal air sacs (alveolarization) requires the development of blood vessels by the process of angiogenesis. Disruption of angiogenesis and alveolarization in infants causes bronchopulmonary dysplasia, the most common complication of premature birth. Our studies will explore if lung immune cells regulate angiogenesis in the developing lung, and identify new pathways to allow the development of therapeutic strategies to promote lung growth and regeneration in both infants and adults with lung disease.

PI_NAMEs: ALVIRA, CRISTINA MARIA (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TITLE: Diverse Homeostatic Roles for Distinct Macrophages in the Developing Lung Vasculature

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


PHR: The formation of the distal air sacs (alveolarization) requires the development of blood vessels by the process of angiogenesis. Disruption of angiogenesis and alveolarization in infants causes bronchopulmonary dysplasia, the most common complication of premature birth. Our studies will identify new pathways that direct angiogenesis in the developing lung, and explore new therapeutic strategies to promote lung growth by enhancing angiogenesis, an approach that may be applicable to diseases affecting both infants and adults.

PROJECT_TITLE: Developmental Heterogeneity of Pulmonary Endothelial Phenotype at Single Cell Resolution


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PI_NAMEs: ANCES, BEAU M (contact)

PROJECT_TERMS: Aging;Autopsy;Biological;Clinical Data;clinical research site;Contracts;Ensure;Geography;HIV;HIV Seronegativity;Midwestern United States;neuroAIDS;Neuropathogenesis;Organ Donor;Persons;Research;Research Priority;Resources;Specimen;Tissues;United States National Institutes of Health;volunteer

PROJECT_TITLE: THE NIH NATIONAL NEUROHIV TISSUE CONSORTIUM (NNTC) - NEW CLINICAL SITE


NIH_SPENDING_CATS: Mental Health

ORG_CITY: PEARLAND

ORG_NAME: BASE PAIR BIOTECHNOLOGIES, INC.

PI_NAMEs: JACKSON, GEORGE W (contact)

PROJECT_TERMS: Adherence;Contracts;Development;HIV;Measures;Phase;Small Business Innovation Research Grant;Tenofovir;Treatment Protocols

PROJECT_TITLE: APTASENSORS FOR MEASURING LONG TERM ADHERENCE TO TENOFOVIR-BASED AND LONG ACTING HIV TREATMENT REGIMENS


FUNDING_MECHANISM: SBIR/STTR CONTRACTS

ORG_CITY: ELLICOTT CITY

ORG_NAME: VITRUVIAN BIO, LLC

ORG_STATE: MD

PI_NAMEs: SENPEN, ANGANA  (contact)

PROJECT_TERMS: Adherence;Biological Assay;Contracts;Development;Devices;HIV;HIV Infections;medication compliance;Monitor;monitoring device;National Institute of Mental Health;Pharmaceutical Preparations;pharmacologic;Phase;Physicians;point of care;prototype;sensor;Small Business Innovation Research Grant;Therapeutic;Viral Load result;Virus Integration

PROJECT_TITLE: NIMH SBIR PHASE 1 TOPIC 001- POINT-OF-CARE HIV VIRAL LOAD AND DRUG ADHERENCE ASSAYS


ORG_CITY: CHELMSFORD

ORG_NAME: TRITON SYSTEMS, INC.

PI_NAMEs: BAI, JING  (contact)

PROJECT_TERMS: 3-Dimensional;analog;blood-brain barrier permeabilization;Coculture Techniques;Communication;Contracts;Development;Gene Expression;In Vitro;in vivo Model;National Institute of Mental Health;neuroAIDS;Neuroimmune;neuroinflammation;Neurons;Neurosphere;novel;Phase;Research;Small Business Innovation Research Grant;System;Tissues;Triton;United States National Institutes of Health

PROJECT_TITLE: SBIR PHASE 1 (NIH/NIMH TOPIC 002 - DEVELOPMENT OF NOVEL IN-VITRO AND IN-VIVO MODELS TO SUPPORT NEUROHIV RESEARCH)TRITON SYSTEMS INC:1185597 [24-001257]


NIH_SPENDING_CATS: Brain Disorders;Mental Health;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN DIEGO

ORG_NAME: VALA SCIENCES, INC.

PI_NAMEs: MCDONOUGH, PATRICK M (contact)

PROJECT_TERMS: Astrocytes;Biological Assay;Biological Models;Brain;Cells;Contracts;Development;HIV;Human;human induced pluripotent stem cells;In Vitro;in vitro Model;in vivo Model;Microglia;National Institute of Mental Health;neuroAIDS;neurotoxicity;novel;Phase;Research;Science;Small Business Innovation Research Grant;System;Testing;Therapeutic;United States National Institutes of Health

PROJECT_TITLE: SBIR PHASE 1 (NIH/NIMH TOPIC 002 - DEVELOPMENT OF NOVEL IN-VITRO AND IN-VIVO MODELS TO SUPPORT NEUROHIV RESEARCH) VALA SCIENCES INC.:1165050 [24-004928]


ORG_CITY: DUBLIN

ORG_NAME: GUILD ASSOCIATES, INC.

ORG_STATE: OH

PI_NAMEs: SMIECHOWSKI, MATTHEW FRANCIS (contact)

PROJECT_TITLE: NIMH SBIR PHASE I  TOPIC 001-  POINT-OF-CARE HIV VIRAL LOAD AND DRUG ADHERENCE ASSAYS


ORG_CITY: NEWTON

ORG_NAME: GINER, INC.

PI_NAMEs: RANA, MUHIT  (contact)

PROJECT_TITLE: NIMH SBIR PHASE I TOPIC 001- POINT-OF-CARE HIV VIRAL LOAD AND DRUG ADHERENCE ASSAYS


ADMINISTERING_IC: AA

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Heavy drinking in young adults is associated with serious negative consequences and is a major public health concern; however, interventions have shown limited efficacy. The goal of this project is to evaluate cognitive- based and mindfulness-based Regulation of Craving Training (ROC-T), which are novel, brief, web-based interventions that directly target core mechanisms implicated in drinking: craving and the regulation of craving. We specifically propose a randomized-controlled trial comparing these interventions to a control condition, and to test the effects on drinking as well as on cognitive, affective, and neural mechanisms.

PI_NAMEs: KOBER, HEDY  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TITLE: Regulation of Craving: Clinical Trial and Neural Mechanisms

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Epstein-Barr virus (EBV) is an oncogenic virus that plays a pervasive role in the pathogenesis of diffuse  large B-cell lymphoma (DLBCL), causing clinically aggressive disease across disparate immunodeficiency  settings of global patient populations. This project aims to comprehensively characterize the genomic  profiles of EBV(+) DLBCL arising in immunodeficiency settings of sub-Saharan Africa and the United  States to identify diagnostic and prognostic biomarkers and ultimately improve clinical outcomes.

PI_NAMEs: VOLARIC, ASHLEY KELLER (contact)

PROJECT_TERMS: Advisory Committees;Africa South of the Sahara;Aggressive behavior;biobank;Bioinformatics;Biological;Biology;Biometry;burden of illness;Categories;Centers of Research Excellence;Clinical;clinically significant;cohort;computerized data processing;Data Analyses;Development;Diagnosis;Diagnostic;diagnostic biomarker;Disease;Disparate;Epstein-Barr pathogenesis;genomic profiles;Genomics;global health;Goals;HIV;Human Herpesvirus 4;Iatrogenesis;immunodeficiency;improved;Infectious Diseases Research;Knowledge;large cell Diffuse non-Hodgkin's lymphoma;Leadership;Lymphoma;Lymphomagenesis;Mediating;Mentors;Mentorship;Molecular Profiling;multiple omics;multiplexed imaging;Oncogenic Viruses;Outcome;Outcome Study;Pathogenesis;Pathogenicity;Pathologic;patient population;Patients;Play;Population;Positioning Attribute;Prognostic Marker;programs;Research;Role;skills;targeted treatment;therapeutic target;United States;viral RNA;Virus Latency

PROJECT_TITLE: EBV-Positive Diffuse Large B-cell Lymphoma: Defining Biologic Determinants of Disease Pathogenesis in Immunodeficiency


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: CHICAGO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative  Cardiovascular disease accounts for nearly 1 of every 3 deaths in the US, an average of 1 death every 38 seconds. The purpose of this project is to use functional genomic assays and novel statistical and computa- tional methods to identify common genetic factors that interact with BPA and phthalates exposure and provide a molecular mechanism for inter-individual variation in endothelial function and cardiovascular health.

PI_NAMEs: LUCA, FRANCESCA  (contact);PIQUE-REGI, ROGER ;WEN, XIAOQUAN

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TITLE: Functional genomics of GxE in cardiovascular disease: BPA, phthalates and their interactions with gene regulation


ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

PHR: Project Narrative Breast cancer is a leading cause of cancer deaths in women largely due to metastasis. We identified an increased association of a novel chemokine ligand CCL24 with a poor prognosis in breast cancer patients. Therefore, we propose determining the clinical significance, oncogenic function, and therapeutic targeting of CCL24 in breast cancer.

PI_NAMEs: KARAN, DEV  (contact);RUI, HALLGEIR

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: aggressive breast cancer;Biological Assay;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;breast cancer progression;cancer cell;Cancer cell line;Cancer Etiology;cancer immunobiology;CCL24 gene;cell motility;Cell Proliferation;Cells;chemokine;Chemotactic Factors;clinically significant;Data;Development;E-Cadherin;epithelial to mesenchymal transition;Estrogen receptor negative;gene function;Genetic;Goals;Health;Human;Immune;immune cell infiltrate;Immunocompetent;Immunosuppression;Immunosuppressive Agents;In Vitro;in vivo;Infiltration;innovation;Interleukin-6;Invaded;knock-down;Knock-out;Leucocytic infiltrate;Leukocyte Trafficking;Ligands;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of prostate;Malignant Neoplasms;Mammary Neoplasms;MCF10A cells;MCF7 cell;MDA MB 231;Mediating;Messenger RNA;Molecular;mouse model;N-Cadherin;Neoplasm Metastasis;Non-Malignant;novel;novel therapeutic intervention;Oncogenic;overexpression;Patients;pharmacologic;pre-clinical;Prognosis;Progression-Free Survivals;promoter;Proteins;recruit;Regulation;Research;Role;Site;Small Interfering RNA;Specimen;Suppressor-Effector T-Lymphocytes;T-Lymphocyte;T47D;Therapeutic;therapeutic target;trafficking;transcriptome sequencing;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Tumor-associated macrophages;Unfavorable Clinical Outcome;United States;Woman;Women's mortality

PROJECT_TITLE: Novel chemokine in the regulation of breast cancer metastasis


ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Raman microscopy grants important advantages over other more common optical techniques, offering expanded multiplexing capabilities for simultaneous visualization of large numbers of distinct biomolecules and structures with high spatiotemporal resolution. This research project focuses on the development of next-generation Stimulated Raman Scattering (SRS) responsive molecular probes to be implemented with complementary SRS microscopy instrumentation to enable high-speed, super-multiplexed visualization of transient molecular species and dynamic processes in live cells

PI_NAMEs: BUCCELLA, DANIELA  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TITLE: Super-Multiplexed Molecular Sensing in Live Cells


ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project Narrative  As the overdose crisis continues, some local prosecutors have increased their use of criminal legal penalties to address overdose deaths—despite evidence suggesting that doing so worsens public health outcomes for people who use drugs and their communities. Using a legal epidemiological framework, this study analyzes (1) the factors that influence prosecutors’ decisions to treat an overdose as a murder instead of a public health issue, (2) how such charges impact the health of people at risk of overdose, and (3) how investment in local public health efforts can decrease the involvement of the criminal justice system in addressing overdose deaths.

PI_NAMEs: EL-SABAWI, TALEED  (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TITLE: The Influence of Public Health Infrastructure on Prosecutorial Responses to the Opioid Crisis

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: CL

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: CLINICAL CENTER

ORG_NAME: CLINICAL CENTER

PI_NAMEs: MANAGEMENT, INCLUSION  (contact)

PROJECT_TITLE: HSCT CLC


ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

PHR: Project narrative Interleukin 33 (IL-33) is a unique member of the IL-1 superfamily of cytokines that regulate innate and adaptive immunity against gastrointestinal pathogens. IL-33 serves as both a pro- and anti-inflammatory mediator of host protective immunity, but the mechanisms responsible remain unclear. This project will investigate the hypothesis that cellular source of IL-33 is a critical determinant in host protective immunity against helminth and protozoan pathogens.

PI_NAMEs: HERBERT, DE'BROSKI R (contact)

PROJECT_TITLE: Myeloid derived IL-33 controls Treg responses during parasite infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative: Douglas A. Mitchell, Ph.D. There are only twenty common amino acids used to produce protein. Chemical modification of is one mechanism by which Nature squeezes more functionality out of a limited set of amino acid building blocks. There are well known “post-translational” modifications, but in our field of study, which focuses on microbial natural product biosynthesis, new exotic modifications are being frequently discovered. This project will define the extent to which these new modifications are employed on larger proteins and the functional significance of those modifications.

PI_NAMEs: MITCHELL, DOUGLAS ALAN (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TITLE: Enzyme Chemistry and Biological Function of RiPP-like Modifications.

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


PHR: Natural products continue to be the most valuable source of drug leads, however, the traditional process of discovering natural products is exceedingly inefficient. This project will accelerate the discovery process by combining the power of genome-mining and reactivity-based screening to rapidly locate novel structures of basic scientific and biomedical interest.

PROJECT_TITLE: Genomics Accelerated Natural Product Discovery


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health because it will define mechanistically how a risk factor for obesity regulates host metabolism through the microbiota. The research will also enhance our understanding of Intelectin-1 on metabolic syndrome and the translational implications of Intelectin-1 interaction with the microbi- ota in early life weight gain and childhood obesity. The proposed studies are relevant to the mission of the NIDDK as our studies are expected to identify new insights into factors associated with metabolic syndrome and eluci- date potential mechanisms and, thus, therapeutic strategies for preventing obesity starting in infancy.

PI_NAMEs: MATUTE, JUAN D. (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TITLE: Intestinal Intelectin-1 regulation of obesity development

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Despite clear evidence of the benefit of integrated care for HIV and opioid use disorder on both HIV and opioid use disorder related outcomes, there is a gap between the evidence and “real- world” practices. The objectives of this proposal are to understand the barriers to integrated care from the patient, provider, clinic, and governmental level in New Jersey and to evaluate the effectiveness of an implementation strategy, that uses coaching and a collaborative learning environment, to help clinics adopt an integrated care model for HIV and opioid use disorder treatment. It is expected that the findings from this project will contribute valuable information about the impact and mechanisms by which implementation science strategies improve the quality of health care delivery to people with HIV and opioid use disorder.

PI_NAMEs: NYAKU, AMESIKA  (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TITLE: Implementing Integrated Services for People With HIV and Opioid Use Disorder

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: Unfortunately, it is challenging to achieve and maintain adequate immunosuppression over time for kidney transplant patients due to variation in the blood levels of immunosuppressive medications. This study will determine if variations in the microbes in the stool are associated with blood levels of immunosuppressive medication named mycophenolate mofetil. We will also determine if variations in the microbes in the human body lead to higher blood levels of this medication and thereby explain the side effects of this medication seen commonly in kidney transplant patients.

PI_NAMEs: GUAN, WEIHUA ;ISRANI, AJAY K (contact);JACOBSON, PAMALA A;STALEY, CHRISTOPHER

PROGRAM_OFFICER_NAME: SWEET, STUART CHARLES

PROJECT_TERMS: absorption;Accounting;Acute;allograft rejection;Anemia;Antibiotics;Area Under Curve;Bacteroides;Beta-glucuronidase;Biliary;Blood;Clinical;Clostridium perfringens;cohort;Diarrhea;Diet;Dose;drug disposition;Drug Kinetics;Enrollment;Escherichia coli;Excretory function;experience;Exposure to;fecal microbiome;fecal transplantation;Feces;fungus;Future;Genes;Genetic Transcription;genetic variant;Glomerular Filtration Rate;Glucuronides;Goals;gut bacteria;gut microbes;gut microbiome;gut microbiota;Hematology;Hour;Human body;Hydrolysis;Immune;Immunosuppression;Immunosuppressive Agents;improved;innovation;inter-individual variation;Investigation;Kidney;kidney allograft;Kidney Transplantation;Lead;Leukopenia;Measures;metatranscriptomics;Methods;Microbe;microbial;microbiome;microbiome composition;microbiome research;microbiota;microbiota profiles;Modeling;multidisciplinary;mycophenolate mofetil;Mycophenolic Acid;Names;Oral;Outcome;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;Pilot Projects;Plasma;Population;predictive test;prospective;Prospective cohort;Randomized;Recycling;Ruminococcus;Sampling;Shotgun Sequencing;side effect;Streptococcus Group B;Tacrolimus;Text Messaging;Time;Toxic effect;transcriptome sequencing;Transplant Recipients;Transplantation;Variant;Work

PROJECT_TITLE: Gut Microbiota and Effect on Immune Suppressants in Transplantation

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: Narrative The binding of glutamate to metabotropic glutamate receptors (mGluRs) and of g-aminobutyric acid (GABA) to GABAB receptors drives signaling cascades that start with G protein binding to the intracellular side of the receptor. We propose to obtain the cryo-electron microscopy (cryo-EM) structures of mGluR2, mGluR5 and GABAB receptor in complex with their G protein partners and interrogate the signaling mechanism with in vitro assays and molecular dynamics (MD) simulations. As defects in glutamatergic and GABAergic signaling are linked to many neurological conditions such as Parkinson's disease, schizophrenia, drug addiction, depression, and pain, this knowledge will be ultimately used for the design of novel therapeutic strategies to combat these disorders.

PI_NAMEs: SKINIOTIS, GEORGIOS  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TITLE: Structural Basis of Signal Instigation Through Family C GPCRs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-C(02)M]


PHR: Narrative Calcium is the most abundant mineral in the human body and its levels are maintained with the help of the extracellular calcium-sensing receptor (CaSR), a cell membrane protein. Genetic and functional defects in CaSR result in diverse diseases related to calcium metabolism: overactive CaSR leads to low blood calcium level (hypocalcemia) that causes muscle cramping and seizures; whereas underactive CaSR results in high blood calcium level (hypercalcemia), hyperactive parathyroid glands (hyperparathyroidism), kidney stones and various neurological disorders. This work will fill the gap in our structural and mechanistic understanding of CaSR function and regulation that are key to human health, and provide insights into the design of new drugs that will alleviate the CaSR associated medical conditions.

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TITLE: Mechanistic Basis of Calcium Sensing Receptor Signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-F(02)M]


ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project narrative The parasite Toxoplasma gondii infects nearly a third of the word population and can lead to severe disease and even death in immunocompromised individuals and those infected congenitally. This parasite possesses a single mitochondrion that is essential for its survival and interestingly changes shape as the parasite goes from cell to cell. Our research aims at identifying the proteins and processes that control the shape of the mitochondrion, which will reveal new ways to target the mitochondrion as a way to combat toxoplasmosis.

PI_NAMEs: ARRIZABALAGA, GUSTAVO A (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Address;Affect;Amino Acids;Apical;Apicomplexa;Automobile Driving;Auxins;Biochemistry;Biological Assay;Biology;Biotinylation;Calcium;Cells;Cessation of life;Co-Immunoprecipitations;combat;Complex;Coupling;Cytokinesis;daughter cell;Development;Disease;domain mapping;Drug Targeting;Economic Burden;Environment;experimental study;extracellular;Health;Homeostasis;human pathogen;Image;Immunocompromised Host;In Vitro;in vivo;Individual;Knock-out;Lasso;Life;Life Cycle Stages;Light;Lipids;Lytic Phase;Mechanics;Mediating;Membrane;Microscopy;Mitochondria;Molecular;Molecular Genetics;Monitor;Morphology;mutant;Mutation Analysis;novel;novel therapeutics;Organelles;Parasites;pathogen;Pharmaceutical Preparations;Phenotype;Phosphorylation Site;Physiology;Plasmodium falciparum;Play;Population;Positioning Attribute;Post-Translational Protein Processing;Process;protein complex;Proteins;Proteomics;Regulation;Research;Resistance;Role;segregation;Shapes;Site;Societies;Stretching;Structure;System;tissue culture;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;Transmembrane Domain;Tubular formation;yeast two hybrid system;Yeasts

PROJECT_TITLE: Regulation of mitochondrial morphodynamics in Toxoplasma gondii

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)M]


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE People with type 1 diabetes suffer chronic complications and are at risk of life-threatening episodes of hypoglycemia and diabetic ketoacidosis. Therapies that increase the number of residual β-cells have been proposed as a strategy to delay or reverse insulin dependence in people with prediabetes or in the “honeymoon” phase of the disease. This research will address whether changes to β-cell metabolism impact the effectiveness of such therapies, opening the possibility for combined drug and dietary interventions to prevent or reverse disease progression.

PI_NAMEs: WORTHAM, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TITLE: Metabolic requirements of pancreatic beta cell proliferation


ORG_CITY: SYRACUSE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Project Narrative Cardiac arrhythmias reduce the quality of life and increase the risk of death for millions of Americans, yet current treatments are inadequate to the scope of the problem. While there are clear genetic factors that contribute to the risk of arrhythmias, the mechanisms through which genetics confer risk remain unclear. The goal of this project is to address this gap in knowledge with the goal of facilitating new therapeutic development.

PI_NAMEs: TUCKER, NATHAN R (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TITLE: From variants to mechanisms for cardiac arrhythmias

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: Acceleration;Area;Clinical;Collaborations;commercialization;data resource;Development;diagnostic technologies;Goals;Government;Home;Industry;innovation;Institution;Knowledge;Medical Imaging;multidisciplinary;network models;new technology;point of care;Point of Care Technology;Readiness;Research;Resources;Technology;technology development;technology research and development

PROJECT_TITLE: MEDICAL IMAGING AND DATA RESOURCE CENTER (MIDRC) - FDA


ORG_CITY: NEW YORK

ORG_DEPT: BIOPHYSICS

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE Laser scanning microscopy is the standard technique for imaging at depth in thick, scattering tissue. However, further scaling of imaging performance is limited by tissue heating. To circumvent this limit, this project seeks to develop new detection modalities based on nonlinear amplification in optical fibers to improve signal-to-noise ratio, imaging speed, and depth penetration for common techniques including optical coherence tomography, confocal, and multiphoton microscopy; thereby representing a new scaling axis for information capacity.

PI_NAMEs: DEMAS, JEFFREY DAKIN (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TITLE: New detection paradigms for laser-scanning microscopy leveraging fiber optical amplifiers


ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Internal targeted radionuclide therapy uses radioactive drugs to destroy tumors and can also be applied for imaging or diagnostic applications. From a therapeutic perspective, those that emit a specific form of radiation called alpha particles are highly effective and have been the subject of many promising clinical trials within recent years, but are generally not amenable for imaging. This project will develop new chemistry to enable the highly efficacious alpha-emitting drugs to be used in conjunction with identical radioactive imaging agents, leading to substantial improvements in patient treatment and diagnosis.

PI_NAMEs: WILSON, JUSTIN J (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Actinium;Actinoid Series Elements;Address;Alpha Particle Emitter;Alpha Particles;Area;Beta Particle;Binding;Biodistribution;Biological;Bismuth;cancer cell;cancer therapy;Chelating Agents;chelation;chemical property;Chemicals;Chemistry;Clinic;Clinical;clinical development;Clinical Research;Clinical Trials;Complex;cytotoxic;design;Development;Diagnosis;Diagnostic;Diagnostic Imaging;Discipline of Nuclear Medicine;Disease;dosimetry;Drug Approval;Drug Industry;Drug Kinetics;Exhibits;Fluorine;Funding;Half-Life;human disease;Image;imaging agent;improved;in vivo;Indium-111;interest;Ions;Lead;Ligands;Linear Energy Transfer;Metals;Modality;Nature;Nuclear Decay;overexpression;patient response;Patients;Penetration;Pharmaceutical Preparations;Photons;Positron;prevent;Property;Radiation;Radiation therapy;Radioactive;Radioisotopes;Radiolabeled;Radionuclide Imaging;Radionuclide therapy;Radiopharmaceuticals;Radium;receptor;response;Staging;success;System;theranostics;Therapeutic;Therapeutic Agents;Therapeutic Intervention;therapy design;translational potential;Treatment Efficacy;tumor;Uranium;Vanadium;vector;Work

PROJECT_TITLE: Chelators to Enable Theranostic Alpha Particle Radiotherapeutic Agents

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

ORG_DEPT: ORTHOPEDICS

PHR: The proposed research is relevant to public health because understanding of the basic biological function of heparan sulfate–cathepsin K interaction is ultimately expected to provide novel therapeutic solutions to treat many diseases associated with undesired bone resorption. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to seeking fundamental knowledge that will help to reduce illness and enhance health.

PI_NAMEs: LIU, JIAN ;XU, DING  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TITLE: The role of heparan sulfate in cathepsin K biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(80)S]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Preterm infants (~0.4 million born in the US yearly) are at risk for frequent blood oxygen drops (Intermittent Hypoxemia (IH)) that are linked to multiple short- and long-term neonatal morbidities leading to both lifelong impairments and increased burden on health care cost. Our study investigates both markers and mechanisms of brain injury from increased intermittent hypoxemia in preterm infants. These data will contribute to our understanding of brain injury from intermittent hypoxemia and identify potential targets for developing treatments in the future to improve IH and associated impairments.

PI_NAMEs: ABU JAWDEH, ELIE G (contact)

PROGRAM_OFFICER_NAME: SEN, ARITRO

PROJECT_TITLE: Systemic Mediators and Biomarkers of Injury in Preterm Infants with Intermittent Hypoxemia

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ED_INST_TYPE: SCHOOLS OF NURSING

ORG_CITY: ARLINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

PHR: Black pregnant women are more likely to experience racial discrimination and depressive symptoms and have higher risk for vitamin D deficiency and preterm birth (< 37 completed weeks gestation) compared with White women. Identifying the genomic inflammatory pathways that relate racial discrimination, depressive symptoms and vitamin D deficiency with preterm birth may lead to early identification of risk for preterm birth for Black women, and development of interventions to reduce preterm birth disparities among these women.

PI_NAMEs: WOO, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: MARTIN, IMAN

PROJECT_TITLE: Genomic signatures of inflammation: Pathways of racial discrimination, depressive symptoms, Vitamin D status with preterm birth among Black women


ORG_CITY: San Diego

ORG_NAME: TING THERAPEUTICS, INC.

PHR: PROJECT NARRATIVE The work in this proposal focuses on further preclinical development of TT003 to protect from aminoglycoside- induced hearing loss. If successful, this proposal will allow Ting Therapeutics to initiate conversations with pharmaceutical companies for the manufacturing and commercialization of TT003 and for IND-approval by the FDA for its use as a standard otoprotective component of aminoglycoside-based therapies.

PI_NAMEs: ZUO, JIAN  (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Acetylcysteine;Acute;Adult;Aftercare;Aminoglycoside Antibiotics;Aminoglycosides;Animal Model;Animals;Anti-Bacterial Agents;Antioxidants;Attenuated;Audiology;Auditory;Auditory Brainstem Responses;authority;Bacteria;Bacterial Infections;Blood;Capsicum;Cavia;Cell Count;Chemosensitization;Clinical;Clinical Treatment;Clinical Trials;Cochlea;Collection;Colony-forming units;commercial application;commercialization;Contracts;Cystic Fibrosis;cystic fibrosis patients;Cytoprotection;Data;design;Detection;Dose;Drug Interactions;Drug Kinetics;drug testing;Drug usage;ebselen;efficacy study;Endotoxemia;Environment;excitotoxicity;experience;experimental study;Food and Drug Administration Drug Approval;Future;Glutamates;Glutathione Metabolism Pathway;Goals;good laboratory practice;Gram-Negative Bacterial Infections;guinea pig model;Hair Cells;hearing impairment;hearing preservation;Hearing Protection;High Pressure Liquid Chromatography;high throughput screening;Human;in vivo;Inflammation;inflammatory marker;International;Intranasal Administration;intraperitoneal;Investigational Drugs;Investments;Jaborandi Pepper;Kanamycin;Knowledge;Labyrinth;Legal patent;Lipopolysaccharides;manufacture;Mass Spectrum Analysis;Measures;Methodology;Modeling;Morphology;mouse model;Mus;Natural Compound;Natural Products;New Drug Approvals;No-Observed-Adverse-Effect Level;Observational Study;otoacoustic emission;otoprotectant;ototoxicity;Outcome;Patients;Perilymph;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacologic Substance;Phase;phase 1 study;Physiological;Population;Pre-Clinical Model;preclinical development;preclinical study;preclinical trial;prevent;prevent hearing loss;Procedures;Proto-Oncogene Proteins c-akt;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Quality of life;Regimen;research clinical testing;Research Contracts;Rights;septic patients;Small Business Innovation Research Grant;Sodium Chloride;STAT3 gene;Study models;technological innovation;Testing;Therapeutic;Therapeutic Index;Time;Toxic effect;Treaty;United States Food and Drug Administration;vitamin metabolism;webinar;Work;Zebrafish

PROJECT_TITLE: Therapeutics to prevent aminoglycoside-induced hearing loss

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-M(12)B]


PHR: PROJECT NARRATIVE The work in this proposal focuses on further development of TT001 to protect from cisplatin- induced hearing loss, an anticancer drug that leaves 40-60% of the treated cancer patients with high frequency hearing loss. If successful, this proposal will allow Ting Therapeutics to initiate conversations with pharmaceutical companies for the manufacturing and commercialization of TT001, for its use as a standard otoprotective component of cisplatin-based therapies.

PI_NAMEs: HUANG, YUNLONG  (contact)

PROJECT_TERMS: Aftercare;Animal Model;Animals;anticancer activity;Antineoplastic Agents;Antioxidants;Audiology;Auditory;Auditory Brainstem Responses;authority;Award;Blood;Cancer cell line;Cancer Patient;cancer therapy;Cavia;CDK2 gene;Cell Death Induction;Cell Line;Chemicals;China;Cisplatin;cisplatin induced hearing loss;Clinical;Clinical Treatment;Clinical Trials;Cochlea;commercial application;commercialization;Contracts;Data;design;Detection;Development;Dose;Drug Kinetics;Drug usage;Ear;efficacy study;Europe;experience;experimental study;Freedom;Future;Glutathione Metabolism Pathway;Goals;good laboratory practice;guinea pig model;Hair Cells;healthy volunteer;hearing impairment;hearing loss treatment;hearing preservation;Hearing Protection;High Pressure Liquid Chromatography;high throughput screening;High-Frequency Hearing Loss;Hong Kong;Human;Immunohistochemistry;in vitro activity;in vivo;inhibitor;International;Investigational Drugs;Japan;Knowledge;Labyrinth;Legal patent;Licensing;Malignant neoplasm of testis;Malignant Neoplasms;manufacture;Mass Spectrum Analysis;Measures;Mediation;Methods;Morphology;mouse model;Mus;neoplastic cell;New Drug Approvals;Observational Study;Oral;otoacoustic emission;otoprotectant;ototoxicity;Outcome;Patients;Perilymph;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacologic Substance;Phase;phase 1 study;preclinical trial;prevent;prevent hearing loss;Procedures;Protocols documentation;Publishing;Quality of life;Regimen;research clinical testing;Research Contracts;Rights;Rodent Model;safety and feasibility;Saint Jude Children's Research Hospital;Small Business Innovation Research Grant;Sodium Chloride;sodium thiosulfate;technological innovation;Testing;Therapeutic;Therapeutic Index;Time;Toxic effect;Toxicology;tumor;tumor xenograft;United States Food and Drug Administration;vitamin metabolism;webinar;Western Blotting;Work;Xenograft Model

PROJECT_TITLE: CDK2 inhibitors for protecting hearing loss


PHR: PROJECT NARRATIVE The work in this proposal focuses on further preclinical development of TT002 to protect from cisplatin-induced hearing loss. If successful, this proposal will allow Ting Therapeutics to initiate conversations with pharmaceutical companies for the manufacturing and commercialization of TT002 and for IND-approval by the FDA for its use as a standard otoprotective component of cisplatin-based therapies.

PROJECT_TERMS: Adult;Aftercare;Animal Model;Animals;Anthelmintics;anticancer activity;Antineoplastic Agents;Antioxidants;Attenuated;Audiology;Auditory;Auditory Brainstem Responses;authority;Benchmarking;Blood;Cancer cell line;Cancer Patient;Cavia;Cell Line;Cestoda;Chemicals;chemotherapy;Cisplatin;cisplatin induced hearing loss;Clinical;Clinical Treatment;Clinical Trials;Cochlea;commercial application;commercialization;Contracts;Data;design;Detection;Dose;Drug Interactions;Drug Kinetics;Drug Screening;drug testing;Drug usage;efficacy study;experimental study;FDA approved;Food and Drug Administration Drug Approval;Freedom;Future;FVB Mouse;Germany;Glutathione Metabolism Pathway;Goals;good laboratory practice;guinea pig model;Hair Cells;healthy volunteer;hearing impairment;hearing preservation;Hearing Protection;Human;Immunohistochemistry;in silico;In Vitro;in vitro activity;in vivo;International;intraperitoneal;Investigational Drugs;Investments;Knowledge;Labyrinth;Legal patent;Liquid Chromatography;Malignant neoplasm of testis;Malignant Neoplasms;manufacture;Measures;Morphology;mouse model;Mus;neoplastic cell;New Drug Approvals;novel therapeutics;Observational Study;Oral Administration;otoacoustic emission;otoprotectant;ototoxicity;Outcome;Patients;Performance;Perilymph;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacologic Substance;Phase;phase 1 study;preclinical development;preclinical evaluation;preclinical study;preclinical trial;prevent;prevent hearing loss;Procedures;Protocols documentation;Publishing;Quality of life;Regimen;research clinical testing;Research Contracts;Rights;Rodent Model;Safety;safety and feasibility;Small Business Innovation Research Grant;Sodium Chloride;sodium thiosulfate;technological innovation;Testing;Therapeutic;Therapeutic Index;Time;Toxic effect;Toxicology;Treaty;tumor;tumor xenograft;United States Food and Drug Administration;virtual;vitamin metabolism;webinar;Western Blotting;Work;Xenograft Model;Zebrafish

PROJECT_TITLE: Preclinical evaluation of an otoprotectant TT002


PHR: PROJECT NARRATIVE Natural killer cells (also known as NK cells) are a type of white blood cell that can target and kill cancer cells and virally infected cells; however, their functions are dysregulated during HIV infection allowing HIV-infected cells to evade their surveillance. The functions of these NK cells are hindered when a carbohydrate-binding protein called Siglec-9, expressed on their surface, binds to specific carbohydrates expressed on the surface of their target (HIV-infected) cells. We developed a novel approach to prevent this binding and thereby enhance the NK cells' ability to target and kill HIV-infected cells; this approach can be used in conjugation with other approaches to cure HIV infection.

PI_NAMEs: ABDEL MOHSEN, MOHAMED  (contact);XIAO, HAN

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TITLE: Targeting Siglec-9/Sialoglycan Interactions to Enhance NK Functions During HIV Infection

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Findings from observational studies and randomized controlled trials suggest that weight loss, physical activity, and a healthy diet potentially attenuate the negative effects of obesity and reduce cancer risk and mortality. Evidence-based weight loss interventions in clinical settings showed health benefits, but not generalizable to rural and Appalachian populations due to their unique characteristics. This application carefully designed series of specific aims to provide insight on health behaviors and lifestyle interventions in rural and Appalachian populations, and to design and deliver an efficacious weight loss intervention to reduce cancer risk and disparities for this population.

PI_NAMEs: ZHANG, XIAOCHEN  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TITLE: Addressing Obesity to Reduce Cancer Risk and Health Disparities in Underserved Populations


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: FORT COLLINS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Narrative When someone suffers a severe brain injury, a portion of the skull must be removed so that the brain can swell. Unfortunately, a second surgery is required to replace that missing piece of the skull, and the patient can experience neurological problems up until the day that missing bone is replaced. In a rat model, we believe that placing our new flexible material during the first surgery that can later turn into bone will still allow the brain to swell initially, while avoiding the second surgery and the neurological problems.

PI_NAMEs: DETAMORE, MICHAEL S. (contact);NUDO, RANDOLPH J.

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: 3D Print;Acceleration;Address;animal model selection;Animals;Anti-Inflammatory Agents;Anxiety;Area;base;Behavior;Behavioral;Biocompatible Materials;biomaterial development;Biomedical Engineering;bioprinting;bone;Bone Matrix;Bone Regeneration;bone repair;Brain;Brain Edema;Brain Injuries;Calvaria;Caring;Cartilage;Cause of Death;Cephalic;Cessation of life;Clinic;Clinical Trials;Closed head injuries;Cognitive;Complication;Control Groups;craniofacial bone;cranium;cranium plastic repair;crosslink;Crosslinker;Custom;Data;Defect;demineralization;design;disability;Drug Delivery Systems;Edema;Emergency department visit;Encephalitis;Evaluation;experience;fascinate;Female;flexibility;Formulation;Goals;Headache;healing;Histology;Hospitalization;Hyaluronic Acid;Hydrogels;Implant;improved;improved outcome;In Vitro;in vivo;in vivo evaluation;Industry;innovation;interest;Intracranial Pressure;Left;Letters;Life;local drug delivery;Magnetic Resonance Imaging;male;Medical;Mental Depression;Modeling;Modernization;Motor;motor deficit;multidisciplinary;Mus;Musculoskeletal;Neurologic;Neurologic Deficit;neurological recovery;neurosurgery;Neurosurgical Procedures;nonhuman primate;novel;Operative Surgical Procedures;Organ;Osteoblasts;osteogenic;particle;particle exposure;Paste substance;Patients;Pharmaceutical Preparations;Pliability;preservation;Procedures;Process;Property;Rattus;Recovery;Regenerative Medicine;Resolution;Rheology;Scalp structure;Solid;Speed;standard of care;Stroke;Surgeon;Survivors;Swelling;Symptoms;synergism;TBI Patients;TBI treatment;Tendon structure;Testing;Thinness;Time;Tissues;tool;translational impact;Traumatic Brain Injury;Ultraviolet Rays;United States;virtual

PROJECT_TITLE: Single stage surgical intervention for treatment of severe traumatic brain injury

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ORG_CITY: CHICAGO

PHR: PUBLIC HEALTH STATEMENT This study has high potential for characterizing novel blood-based biomarkers to identify preclinical ADRD and test their utility in predicting clinical ADRD. No other study has a similar design with repeated blood mtDNA mutations, cognitive assessments, and brain imaging data during midlife, a critical time window for interventions to prevent clinical ADRD development. By also using data from four large cohorts of older adults, we can determine the clinical utility of these mtDNA biomarkers to predict clinical ADRD and move the field closer toward the NIH’s goal of personalized health interventions.

PI_NAMEs: HOU, LIFANG  (contact);YAFFE, KRISTINE

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TITLE: Blood mitochondrial DNA biomarkers of midlife cognitive decline and adverse brain imaging changes - A longitudinal investigation in the CARDIA population-based cohort study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(56)]


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic malignancy in children and young adults that frequently becomes treatment-refractory and relapses. This project seeks to define novel mechanisms of immune evasion in T-ALL. It will lead to development of novel and transformative therapeutic strategies through targeting T-cell exhaustion for patients with high-risk T-ALL.

PI_NAMEs: KNOECHEL, BIRGIT  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TITLE: Mechanisms of immune evasion in T-cell acute lymphoblastic leukemia and its therapeutic implications

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The increasingly crucial role played by family and friend caregivers of patients with advanced cancer is complicated by existential distress, but to date, current psychosocial interventions fail to address such distress. This project is relevant to NIH’s mission as it represents a critical step in the refinement of a targeted intervention–Meaning-Centered Psychotherapy for Cancer Caregivers (MCP-C)–that has shown encouraging results in improving caregivers’ sense of meaning in life and spiritual wellbeing and ameliorating anxiety and depression. If successful, MCP-C holds significant promise to not only improve the quality of life for caregivers across the caregiving trajectory from diagnosis through bereavement, but also to yield downstream benefits to the patients for whom they provide care.

PI_NAMEs: APPLEBAUM, ALLISON  (contact)

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TITLE: Meaning-Centered Psychotherapy to Meet Palliative Care Needs of Cancer Caregivers

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: SAN FRANCISCO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: A major challenge of genomic medicine is to convert the large catalogue of disease- associated variants and gene expression states into actionable therapeutic targets. The proposed aims will build the foundational knowledge base and tools for controlling gene expression in human cells by delivering synthetic constructs that trigger epigenetic memory of gene expression states. These aims will pave the way for future epigenetic therapeutic strategies that open large portions of the human genome to direct therapeutic targeting with high precision for disease pathophysiology.

PI_NAMEs: HSIUNG, CHRIS CHUAN SHU (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TITLE: High-throughput engineering of combinatorial chromatin signals and epigenetic cellular memory

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE Drug therapy is required to treat trypanosomatid parasite infections, yet existing drugs suffer from challenging treatment regimens, emerging drug resistance, and significant gaps in our understanding of their mechanisms of action and trypanocidal targets. The proposed research will use a state-of-the-art genetic screening tool to identify genes whose expression promotes resistance against the clinically relevant anti-trypanosomatid drugs currently in use. The phenotypes imparted by multi-resistance genes will then be evaluated to identify pathways that result in drug resistance and, conversely, cell death, the outcomes of which will be transformative for future drug development in trypanosomatid parasites.

PI_NAMEs: HOVEL-MINER, GALADRIEL ASTRA (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TITLE: Dissecting multidrug resistance pathways in Trypanosomatids

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-F(83)]


PHR: PROJECT NARRATIVE Fexinidazole is the promising first oral monotherapy against Human African Trypanosomiasis and is being explored for the treatment of other trypanosomatid infections, yet its mechanism of action, cytotoxic effects, and potential for drug resistance have not been thoroughly investigated. Here, a state-of-the art forward genetic screen has identified proteins with functions in redox and ROS metabolism in a putative fexinidazole resistance pathway, the specificity of which will be evaluated in this proposal through additional targeted genetic screens. Proteins promoting fexinidazole resistance will be analyzed using an unbiased phenotyping pipeline that will provide functional data, determine the role of ROS and redox in drug resistance, evaluate their potential as novel drug targets, and, ultimately, be transformative in the treatment of trypanosomatid infections.

PROJECT_TITLE: Fexinidazole survival genes implicate a novel redox-based mechanism in drug resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(83)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The proposed research focuses on tuberculosis (TB) in Malawian children under five years old (U5s), an age group with unacceptably and disproportionately high mortality from TB. The accuracy of promising new TB diagnostic strategies that utilize non-invasively collected specimens will be evaluated, and the pharmacokinetics of first-line antituberculosis therapy in the face of co-prevalent severe acute malnutrition will be described. This research will provide valuable insights into the diagnosis and management of TB in U5s and set the stage for more expand efforts to fill knowledge gaps in these areas going forward.

PI_NAMEs: VONASEK, BRYAN  (contact)

PROGRAM_OFFICER_NAME: JESSUP, CHRISTINE

PROJECT_TITLE: Tuberculosis in Malawian children under five years old: exploring non-invasive diagnostic strategies and the impact of malnutrition on treatment pharmacokinetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-W(55)R]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Post-translational modifications, or the structural modification of a protein after it is folded, of key heart contractile proteins (cMyBP-C) lead to the quick and precise regulation of the heart. These modifications appear dysfunctional in cardiac myosin binding protein-C (cMyBP-C) during heart disease. In this proposal, we aim to study the functional consequences of modifying cMyBP-C under normal conditions, elevated stress, and therapeutically treated states of the heart to better understand the consequences of these protein modifications and, ultimately, to determine if altering these modifications can lead to improved heart health.

PI_NAMEs: GREENMAN, ANGELA  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TITLE: The role of S-glutathione in regulating cardiac myosin binding protein-C function


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: This project investigates how human cytomegalovirus (HCMV) cloaks itself in a “sugar shield” to escape from antibodies and other immune defenses. HCMV causes life-threatening opportunistic infections in immune compromised people and is the #1 viral cause of birth defects that lead to permanent hearing loss and other neurodevelopmental disabilities in young children. The studies proposed in this project will generate new information that can be harnessed toward the development of effective vaccines and therapies against HCMV and other persistent enveloped viruses.

PI_NAMEs: KAMIL, JEREMY PHILLIP (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TITLE: Roles of the UL148 glycoprotein in human cytomegalovirus infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-G(02)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

PHR: Project Narrative This program centers on developing new organometallic catalysts that can selectively activate different groups on organic molecules according to the wavelength of light irradiation. This will allow for the iterative synthesis of biological targets in one-pot, facilitating rapid access to chemical libraries for medicinal screening and the optimization of biological function. The new technologies developed in the formation of carbon-carbon bonds will also be amenable to automated synthesis platforms of use in medicinal chemistry laboratories.

PI_NAMEs: SANDFORD, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Switchable Organometallic Catalysts for Organic Reaction Development

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


PHR: Project Narrative  Heart failure is associated with unacceptably high morbidity and mortality worldwide despite currently available medical and device therapies, highlighting the need for deep mechanistic research in this field. Dead box helicase (Ddx) proteins play important roles in RNA splicing and processing. A key member of this protein family, Ddx5 has not been studied in the heart, and in this proposal, we will elucidate its role in cardiac function and disease.

PI_NAMEs: TOPKARA, VELI KEMAL (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TITLE: Role of RNA helicase Ddx5 in pathological cardiac remodeling

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: LORETTO

ORG_NAME: APPLIED UNIVERSAL DYNAMICS CORPORATION

ORG_STATE: MN

PHR: Project Narrative Parkinson's disease is the second most common neurodegenerative disease, affecting 1% of Americans older than 65. Parkinson's disease is a complex disease affecting a wide range of organ systems and impacting patients in a variety of ways. The motor features of Parkinson's disease including tremor, gait and balance dysfunction are well known, but non-motor features of Parkinson's disease such as those affecting cognition, sleep, and gut absorption are wide ranging and less well known but have a significant impact on patient quality of life. The management of Parkinson's disease is complex and subspecialty care by a movement disorders neurologist is important for extending quality of life for as long as possible. This project seeks to develop improved technology for use in rural environments to aid in the diagnosis and management of Parkinson's disease patients.

PI_NAMEs: HAVEY, GARY D (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TITLE: Ring wearable sensor use for diagnosis and monitoring of Parkinson's disease in underserved rural populations


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE: Age-related macular degeneration (AMD), the most common cause of blindness among the elderly, is initiated by retinal pigmented epithelial (RPE) degeneration due to lysosomal dysfunction. Dysfunction of lysosomes can affect the normal functioning of the cellular clearance process to cause disease. This proposal will determine the extent that transcription factor EB (TFEB) activation by gene therapy can restore lysosomal function, RPE degeneration, and an AMD-like phenotype using an AMD-like mouse model and in human-iPSC derived RPE cells from AMD donors.

PI_NAMEs: HANDA, JAMES T;SINHA, DEBASISH  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TITLE: Targeting lysosome/RPE heterogeneity in AMD pathobiology as a novel therapy

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: The goal of these studies is to understand how nerves in the nasal epithelium may detect fungal allergens and interact with other cells to initiate allergic inflammation. We think that nerves become activated by fungal allergens and secrete specific proteins that cause specialized cells in the epithelium to proliferate and initiate the early stages of inflammation. We also think that both neurons and inflammation worsen sneezing.

PI_NAMEs: HERBERT, DE'BROSKI R (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TITLE: Neuronal regulation of sinonasal Type 2 inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RCCS-B(03)]


ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Pediatric subglottic stenosis (SGS) is a common disorder that is challenging to diagnose due to a varying clinical spectrum and major limitations in the gold-standard severity grading scale. In this proposal we demonstrate a novel diagnostic pipeline that combines engineering analysis and computer vision algorithms to provide personalized and objective diagnostic measures of stenosed airway physiology. The analysis pipeline is widely adoptable, provides novel precision metrics to guide patient management, and thus has the potential to transform the clinical care of this sensitive population.

PI_NAMEs: BARBOUR, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TITLE: Computer-Vision and Computational Fluid Dynamics Analysis Pipeline to Improve Diagnosis in Pediatric Subglottic Stenosis

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: ZOOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: STATEMENT OF PUBLIC HEALTH SIGNIFICANCE Salmonella enterica serovar Typhimurium is a NIAID category B priority pathogen and a leading cause of morbidity and mortality from enteric disease globally. Colonization of cockroaches by S. Typhimurium not only provides an environmental reservoir and vector-borne transmission route for the pathogen but also creates a unique interphase for the evolution of variants with concerning properties such as antimicrobial resistance. An improved understanding of how passage of S. Typhimurium through cockroach vectors influences pathogen genotype and phenotype will provide novel, naturally relevant insight into pathogen evolution and may suggest insect control as a simple intervention to mitigate evolution of enteric pathogens.

PI_NAMEs: PIETRI, JOSE ENRIQUE (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TITLE: Evolution of Salmonella in a cockroach vector


ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Our preliminary findings show that RNA abasic sites are abundant, and they stabilize R-loops to regulate the transcription of noncoding RNA. To understand the scope of gene regulation by RNA abasic sites, we will identify their regulatory role genome-wide, identify the enzymes that form RNA abasic sites, and the bases that are removed to form the abasic sites.

PI_NAMEs: CHEUNG, VIVIAN G (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TITLE: Determining the role of RNA abasic sites in gene regulation

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ORG_CITY: OMAHA

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PI_NAMEs: RENAULD, JUSTINE MARIE (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TITLE: Understanding the progression of hearing loss in an endolymphatic hydrops model


ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Type 2 diabetes (T2D), a major risk factor for poor bone quality and fractures, is associated with the premature accumulation of senescent cells and advanced glycation endproducts (AGEs; activators of the receptor for AGE [RAGE] pathway) in multiple tissues. Intuitively, senescent cells and RAGE could act independently or interact via cross-talk to contribute substantially to skeletal fragility and dysfunction of other systems and physiological processes in T2D, yet this concept has not been rigorously tested. In this proposal, we will test the hypothesis that targeting senescent cells and RAGE signaling in mice can alleviate or partially reverse T2D and its complications, including skeletal fragility.

PI_NAMEs: FARR, JOSHUA NICHOLAS (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TITLE: Targeting Cellular Senescence and RAGE in Type 2 Diabetes

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

PHR: NARRATIVE — HEALTH RELEVANCE Cardiometabolic conditions, such as type 2 diabetes mellitus and hypertension, increase the risk for fractures, which is a substantial public health problem in older adults in the United States. The proposed study will utilize 25 years of previously collected data regarding biomarkers and incident cardiometabolic disease from the Coronary Artery Risk Development in Young Adults (CARDIA) study, and add validated vertebral strength data, to further our understanding on how cardiometabolic disorders and hallmarks of cardiometabolic disease over the life span impact vertebral strength, a surrogate for vertebral fracture risk.

PI_NAMEs: WRIGHT, NICOLE C (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TITLE: Evaluating the Association between Cardiometabolic Health Over the Lifespan and Vertebral Strength

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Dysregulation of mitochondrial homeostasis is a major contributor to human disease. This project aims to explore the role of mitochondrial dynamics in the innate immune system by investigating the interplay between mitochondrial fission, oxidative stress, and cardiolipin externalization in regulating inflammation and cell death in macrophages. The findings will enhance our understanding of the regulatory role of mitochondrial dynamics in the innate immune system and potentially inform the development of novel therapeutic interventions targeting mitochondrial function and homeostasis.

PI_NAMEs: MARTINEZ, EDUARDO  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TITLE: Uncovering the role of cardiolipin in promoting gasdermin D-mediated necroptosis and hyperinflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07B-G(20)]


ORG_CITY: Los Angeles

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative We have developed techniques to regenerate the injured heart using stem cells that restore pump function but make the heart electrically unstable for several weeks. This proposal aims to solve this electrical instability by reprogramming stem cell metabolism and gene regulation. If successful, these studies can lead to a transformative regenerative therapy that could help millions of patients suffering from heart disease.

PI_NAMEs: MURRY, CHARLES E (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TITLE: Metabolic and Transcriptional Reprogramming of Cardiac Maturation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CCHF-S(01)]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: NARRATIVE Sarcoma are metastatic and aggressive tumors, for which therapies have not improved in the last years. Novel studies have been impeded by the paucity of appropriate experimental tools and reliable mouse models. Accordingly, we propose: i) to generate and characterize novel reliable sarcoma mouse models that carry the most frequent genetic alteration found in patients ii) illuminate the expression profile of the sarcoma cells and discrete sub-clusters of them, to understand how these profiles influence the TME composition, and iii) to test how these models respond to different radiotherapy administration schedules.

PI_NAMEs: GUARNERIO, JLENIA  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TITLE: Comparative modeling of sarcoma microenvironments for the discovery of biomarkers and tumor vulnerabilities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-N(55)R]


ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PI_NAMEs: MOYSICH, KIRSTEN B. (contact);ODUNSI, KUNLE

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TITLE: Enhancing Personalized Care in Ovarian Cancer Through Prospective Exercise Interventions and AI-Driven Data Integration


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE HIV-1 associated neuroinflammation and neurotoxicity lead to cognitive impairments (HIV-1-associated neurocognitive disorders or HAND) even in those under suppressive antiretroviral therapy (ART). Using HIV-1 infected cerebral organoids from induced pluripotent stem cells, we will provide novel insights into the pathogenesis of HAND, Tat mediated neurotoxicity, effects of cocaine, and HIV-1 latency in the brain.

PI_NAMEs: NIXON, DOUGLAS F (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TITLE: Development of Brain Organoids to Study the Impact of HIV-1, Drugs of Abuseand Aging on Cognitive Impairment


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

PHR: Project Narrative In the United States, two-thirds of the 5.4 million people with memory concern (PWMC) live in their homes in the community, reflecting the growing desire of Americans to age in place. The complexity of needs of PWMC including medical, behavioral, and social needs, make it one of the most expensive chronic conditions in the United States, and a strong candidate for improving care through care management support. Navigating fragmented systems of health care, long-term services and supports, and community or social supports to meet the diverse needs of PWMC is challenging. Currently, family, and unpaid caregivers provide the bulk of support PWMC receive to continue living in their homes. Caregiver burden, measured objectively (count of hours) or subjectively (caregiver’s perception of impact on themselves), is associated with poorer outcomes among people living with dementia. Given most PWMC live in their homes, people are concentrating on the home setting as an effective way to identify and address a broader set of unmet needs (e.g., social, and environmental determinants of health) and provide more comprehensive “family-centered” support. This approach aligns with value-based care principles and bridges the health care with community setting.

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TITLE: A Mobile Informatics Solution to Assist Caregivers with Care Coordination and Social Engagement


ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Project Narrative Alveolar macrophages are the first host cells to be infected when Mtb is inhaled, and until recently they have been regarded as a homogeneous, anti-inflammatory population that is permissive for Mtb infection. However, our recent work revealed subpopulations of AMs that are capable of pro-inflammatory responses and able to contain Mtb growth. In the proposed project, we will study the molecular mechanisms that cause CD38- AMs to be non-responsive to Mtb infection, which will advance our fundamental knowledge of the underlying AM biology and enable us to identify potential therapeutic targets for immune-mediated control of Mtb growth.

PI_NAMEs: PISU, DAVIDE  (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TITLE: Elucidation of the molecular mechanism(s) for the non-responsiveness of CD38- AMs to tuberculosis infection

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative This revised application focuses on the discovery that melanoma are selectively addicted to the lysine catabolism enzyme GCDH, which controls NRF2 glutarylation, impacting transactivation of apoptotic UPR signaling in melanoma. The newly discovered GCDH-NRF2-UPR axes constitutes a novel paradigm for control of melanoma survival and offers novel therapeutic targets.

PI_NAMEs: OLSON, STEVEN H;RONAI, ZEEV A. (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TITLE: GCDH Addiction in Melanoma

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]