ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative Many classes of natural products have tremendous potential as therapeutics or as biological tools but have structural liabilities that limit their utility. Our lab uses modular chemical synthesis with accompanying methodology development to enable systematic modification of promising chemical scaffolds to overcome such liabilities. This proposal outlines several examples of this approach for molecules with anticancer, antibiotic, and antiviral properties.

PI_NAMEs: SEIPLE, IAN BASS (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Modular synthesis of antibiotic and anticancer classes of natural products


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: UROLOGY

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Resistance to current AR-targeted therapies poses a significant hurdle in treating advanced prostate cancer (PCa), severely affecting clinical outcomes for patients battling this lethal disease. Our research has identified a prevalent ZNF397 deficiency, observed in 25-40% of PCa patients, which propels the transition of cancer cells from an AR-driven luminal lineage to a TET2-driven lineage plastic state, thereby fostering AR-targeted therapy resistance. This study aims to unravel the molecular mechanism behind ZNF397-deficiency-induced lineage plasticity and AR-targeted therapy resistance, with a goal to develop innovative therapeutic approaches to overcome resistance and benefit patients suffering from this devastating disease.

PI_NAMEs: MU, PING  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TITLE: Deciphering the Impact of ZNF397-deficiency in Promoting TET2-driven Epigenetic Rewiring, Lineage Plasticity, and Therapy Resistance in Prostate Cancer

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


PHR: PROJECT NARRATIVE Overall research plans/aims have NOT changed. Resistance to current AR-targeted therapies poses a significant hurdle in treating advanced prostate cancer (PCa), severely affecting clinical outcomes for patients battling this lethal disease. Our research has identified UBE2J1 as the bona fide E2 ubiquitin-conjugating enzyme regulating AR ubiquitination and revealed its frequent loss in 10-15% patients leads to dysregulated AR degradation and therapy resistance. This study seeks to elucidate the previously uncharted molecular mechanisms behind AR degradation and resistance to therapy in the context of UBE2J1-loss, with the ultimate goal of devising novel therapeutic strategies to counteract resistance and enhance patient outcomes.

PROGRAM_OFFICER_NAME: KOHAAR, INDU

PROJECT_TITLE: Unveiling the Role of UBE2J1 as the E2 Ubiquitin Conjugating Enzyme in Androgen Receptor Degradation


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NEW ORLEANS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Public Health Relevance Statement Dendritic cells (DC) are professional antigen presenting cells that serve critical roles in both innate and adaptive immune responses. This project investigates how DC focally deliver cytokines like interleukin 33 to T cells for shaping the inflammatory vs. anti-inflammatory responses generated within the respiratory mucosa through mechanisms dependent upon the enigmatic pore-forming protein Perforin-2.

PI_NAMEs: HERBERT, DE'BROSKI R (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TITLE: Perforin 2 controls unconventional cytokine release from mucosal APC


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: TUCSON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Dysmenorrhea (characterized by menstrual pain) affects up to 95% of reproductive-age women, disrupts their daily activities, and increases their risk for other chronic pain conditions. We propose to examine relationships among vaginal microbiome, inflammatory mediators, metabolome, sex hormones, and individual differences in dysmenorrhea symptoms. This study is expected to discover new evidence that could lead to expanded treatment options for the most common gynecological pain condition.

PI_NAMEs: CHEN, CHEN X (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TITLE: Vaginal Microbiome, Inflammatory Mediators, Metabolome, and Dysmenorrhea Symptom-based Phenotypes

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: NARRATIVE African American women are disproportionally covered by Medicaid and are at greater risk than non-Hispanic white women of losing insurance coverage after pregnancy and of poor maternal health outcomes. Dr. Steenland will train in domestic health policy, maternal health, and advanced econometric methods to prepare her to complete her research aims and for a career as an independent investigator focused on health policy solutions to reduce poor maternal health outcomes among racial/ethnic minority women. In the proposed research aims, Dr. Steenland will examine the effect of Medicaid expansion on disparities in postpartum insurance coverage nationally, and the effect of Medicaid expansion in Arkansas, the state with the largest coverage gains after Medicaid expansion, on disparities in postpartum health care use in Arkansas.

PI_NAMEs: STEENLAND, MARIA WARD (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Reducing Postpartum Health Care Disparities through Increased Insurance Coverage after Childbirth

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ORG_CITY: SALT LAKE CITY

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Mosaic mutation in sperm is an important source of new mutations and underlies sporadic genetic risk for congenital diseases in offspring, this proposal aims to uncover how mutations in single sperm look like, what impacts they have, and how they accumulate with age. I will obtain training in the related fields of reproductive medicine and human subjects, as well as develop both computational and experimental technologies to study the genomes of individual single sperm and generalize them to other studies. The proposed project will not only advance novel technologies for the analysis of single sperm genomes and detect mosaic variants but will also advance a fundamental understanding of paternal non-clonal sperm mosaicism and predict its significant contributions to child health.

PI_NAMEs: YANG, XIAOXU  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TITLE: Understanding genomic stability between generations by assessing mutational burdens in single sperms

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: AMHERST

ORG_DEPT: CHEMISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative The proposed work will arm medicinal chemists with a new suite of chemical reactions that can expedite our society’s ability to synthesize small molecule therapies, a major bottleneck in our efforts to address critical health needs. The key strategy is predicated on using energy from visible-light to drive chemical transformations that may make life-saving therapeutics in an efficient, robust and enabling manner. The motivation for our work is to protect life by lowering the barrier to making pharmaceutical compounds that will treat diseases, reduce disabilities, and enhance the quality of life.

PI_NAMEs: MUSACCHIO, PATRICIA ZHANG (contact)

PROJECT_TITLE: Mild Strategies in the Direct Generation of Carbocation Intermediates from C(sp3)–H Bonds

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: KANSAS CITY

ORG_NAME: KANSAS CITY VA MEDICAL CENTER

ORG_STATE: MO

PHR: This proposal addresses a significant healthcare issue that affects Veterans, military personnel, and their families disproportionately. In this regard, the incidence of Inflammatory Bowel Disease (IBD) is increasing in Veterans at disproportionate rates than the general population. Dr. Singh’s research program is focused on the investigation of mechanism/s of IBD to discover novel biomarkers and/or therapeutic targets to curb disease severity in IBD patients, and its progression to colon cancer. Both, IBD and colon cancer represent major clinical challenges in the VA health care system, since effective therapeutic interventions are lacking. Similar to IBD, incidence of PTSD is increasing in Veterans at disproportionate rates. Applicant’s lab aims to provide a better understanding of mechanism/s of increasing risk for PTSD and its causal role in promoting IBD to increase opportunities for the development of novel biomarkers and treatment paradigms.

PI_NAMEs: SINGH, AMAR B (contact)

PROJECT_TITLE: BLRD Research Career Scientist Award Application


PHR: Inflammatory bowel disease (IBD) is a conglomerate of debilitating auto-immune disorders of the gastrointestinal tract, which significantly affect one’s lifestyle including active-duty army personnel and the Veterans. Studies for the Department of Veterans Affairs however found that the incidence of IBD among Veterans has recently increased 2-3 folds. An improved understanding of the causal regulation of this increase in IBD in Veterans can open novel therapeutic opportunities. In this proposal, we will perform “Proof-of-Concept” and mechanistic research to understand the causal role of Gut Microbiota associated with Post-Traumatic Stress Disorder (PTSD) in the Veterans in promoting IBD risk and severity. Critical concepts that will be evaluated include whether PTSD- associated Gut Dysbiosis promotes IBD risk by synergizing with gut barrier dysfunctions. Anticipated outcome from the proposed studies will have significant impact upon the clinical management of IBD, the quality of life of the Veterans IBD patients, and in reducing the economic burden of the VA-hospital system.

PROJECT_TITLE: Role of PTSD associated gut dysbiosis and barrier dysfunctions in promoting IBD in Veterans


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative Abnormal vision during a childhood ‘critical period’ can cause amblyopia, also known as lazy eye, a disorder comprising several deficits in spatial vision including impaired binocular depth perception. The proposed research is relevant to public health because knowledge of the neuronal basis and developmental timeline of binocular depth perception will improve our understanding of targets for therapeutic intervention. The proposed research is relevant to the mission of the NEI/NIH to increase understanding of how the development of the visual system and visual experience results in binocular depth perception.

PI_NAMEs: MCGEE, AARON W (contact);SAMONDS, JASON M

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TITLE: Cortical basis of binocular depth perception

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-U(02)M]


ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

ORG_STATE: PA

PHR: NARRATIVE The studies proposed herein will determine the impact of BCL2, a protein that supports the survival of cancer cells responding to treatment, on the immunological configuration of hormone receptor (HR)+ breast cancer (BC), as well as the therapeutic value of combining radiation therapy (RT) with BCL2 inhibitors in immunocompetent mouse models of HR+ BC. These findings will provide preclinical ground to the initiation of clinical trials testing RT plus venetoclax (a BCL2 inhibitor currently approved by regulatory agencies for use in patients with chronic lymphocytic leukemia) in women with HR+ BC, a type of BC that still affects >200,000 and kills >25,000 new women every year in the US.

PI_NAMEs: GALLUZZI, LORENZO  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TITLE: Targeting the BCL2 immune checkpoint to enhance the immunostimulatory effects of radiation in breast cancer

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE By taking a complex systems approach, we can assess how physical activity behavior determinants operate in combination over time and differ across children to inform physical activity interventions and policies. Given pronounced health disparities in physical activity behaviors (and common chronic diseases that could be improved and/or prevented through physical activity) actions tailored to maximize impact could be a powerful health disparities reduction strategy.

PI_NAMEs: BARKIN, SHARI  (contact);HAMMOND, ROSS A.

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TITLE: Early Childhood Physical Activity: A Dynamic Systems Approach to Reducing Health Disparities

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ORG_CITY: CHICAGO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The protein, eIF4E, is important to normal cells and when dysregulated can drive the development of a broad array of cancers. eIF4E does this by co-opting the signal from the DNA (known as RNA) allowing it to generate more of the proteins that can drive cancer. In this proposal, we identified a new mechanism by which eIF4E uses this activity to imbue cancer cells with the ability to move, and thus invade neighboring tissue. We can exploit this new knowledge to ultimately develop new therapeutic strategies for high-eIF4E cancers.

PI_NAMEs: BORDEN, KATHERINE L B (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TITLE: Oncogenic Impact of eIF4E-dependent RNA Export in Cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: NARRATIVE The metabolic switch observed in GBM leads to increased glycolysis in tumor cells and impacts the tumor microenvironment, which in turn acts as a major barrier for successful targeting of cancer by anti-tumor immune cells like T cells. The tremendous increase in tumor glucose consumption imposes a great metabolic pressure on T cells, which experience glucose restriction. The overarching goal of this project is to manipulate the metabolic fitness of chimeric antigen receptor (CAR) modified T cells to ameliorate their tumoricidal activity in the context of immunotherapy to treat GBM

PI_NAMEs: DELEYROLLE, LOIC PIERRE (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TITLE: Optimizing CAR T therapy via metabolic engineering for thetreatment of GBM


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because we aim to improve prognostication for patients with advanced cancer by developing frameworks to integrate clinician intuition with machine learning algorithm- based mortality risk predictions (“human-machine collaborations”), a critical step to better identify patients who may benefit from earlier advance care planning and palliative care. This research proposal will optimize an existing machine learning mortality risk prediction algorithm and methodologically assess strategies to present machine learning estimates to clinicians in order to increase prognostic accuracy, advance care planning, and palliative care among patients with advanced cancer. The project is relevant to the NCI's mission by generating fundamental knowledge to inform clinicians, researchers, and policymakers about effective methods to improve and integrate predictive algorithms into clinical practice, thereby allowing better targeting of evidence-based interventions to improve quality of life for patients with advanced cancer.

PI_NAMEs: PARIKH, RAVI BHARAT (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TITLE: Human-Machine Collaborations to Improve Prognosis and Clinical Decision-Making in Advanced Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


PHR: PROJECT NARRATIVE Around 50% of infants born extremely preterm develop a chronic lung disease known as bronchopulmonary dysplasia of which some infants will also develop pulmonary hypertension of which 50% of children will die before the age of 2. Physicians are currently limited in their (1) ability to predict which infants will develop this more severe form and (2) ability to select the most appropriate therapy that will improve outcomes in infants with this condition. This proposal will develop a tool to predict which infants are more likely to develop bronchopulmonary dysplasia and pulmonary hypertension, will examine whether currently used therapies for this disease improve infants' condition, and determine whether using different amounts of oxygen improve outcomes in infants with this disease.

PI_NAMEs: GENTLE, SAMUEL J (contact)

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TITLE: Therapeutic Strategies for the Management of Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Hirschsprung-associated enterocolitis (HAEC) is a life-threatening complication of Hirschsprung Disease, a common cause of intestinal obstruction in the newborn that results from incomplete development of the enteric nervous system. The etiology of HAEC is poorly defined and current treatment remains empiric and directed toward alleviating acute symptoms rather than targeting underlying pathophysiology. This proposal will define the role of dysbiosis in the pathophysiology of HAEC and test novel therapeutic approaches for prevention or treatment of HAEC.

PI_NAMEs: GOSAIN, ANKUSH  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TITLE: Dysbiosis in Hirschsprung Associated Enterocolitis Pathogenesis


PHR: Project Narrative The protein, eIF4E, is important to normal cells and when dysregulated can drive the development of a broad array of cancers. eIF4E does this by co-opting the signal from the DNA (known as RNA) allowing it to generate more of the proteins that can drive cancer. In this proposal, we identified a new mechanism by which eIF4E not only increases the protein-coding capacity of an RNA, but changes its structure, by subverting a process known as splicing. We can exploit this new knowledge to ultimately develop new therapeutic strategies for high-eIF4E cancers.

PI_NAMEs: BORDEN, KATHERINE L B (contact);GUZMAN, MONICA L

PROJECT_TITLE: Molecular Mechanisms of eIF4E Mediated Transformation


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This study will assess the effects of physician dispensing of oral specialty drugs (i.e., dispensing of medications directly to patients by the physician) for advanced prostate cancer on utilization, financial consequences, and safety. Results from this study will have real-world implications for men with advanced prostate cancer, who are intent on getting the highest quality cancer care while avoiding financial consequences and toxicity associated with these medications.

PI_NAMEs: HOLLENBECK, BRENT K. (contact);SHAHINIAN, VAHAKN B

PROGRAM_OFFICER_NAME: DAVIDOFF, AMY

PROJECT_TITLE: Physician dispensing of oral specialty drugs for advanced prostate cancer and its implications for patients

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Diabetes is a complex disease that is defined by poor control of blood sugar. Loss of blood sugar control is related to a poor functioning pancreas, which is worsened in individuals who yo-yo diet, or weight cycle. The goal of this project is to identify the mechanisms of how body weight fluctuations evoked by weight cycling worsen pancreatic function and blood sugar control.

PI_NAMEs: WINN, NATHAN C (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TITLE: Uncovering mechanisms of pancreatic adaptability to weight cycling

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

PI_NAMEs: CHAMCHEU, JEAN CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TITLE: Development of natural and synthetic compounds as novel potentiators of HSV-1 VC2-GMCSF-based oncolytic viral therapy in Breast Cancer


ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Small cell lung cancer (SCLC) remains relatively refractory to multiple therapeutic modalities, including immune checkpoint blockade, despite its high tumor mutation burden. This proposal seeks to exploit newfound immunologic vulnerabilities of SCLC conferred by epigenetic control of MHC Class I antigen presentation. Rational targeting of distinct immunologic subtypes of SCLC could lead to a deeper understanding of epigenetic modulation of immunogenicity, and, ultimately, novel immunotherapies for this treatment-refractory tumor.

PI_NAMEs: MAHADEVAN, NAVIN  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TITLE: Targeting the immunologic vulnerabilities of small cell lung carcinoma


ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative This innovative study will establish a new oncogenic pathway as a therapeutic target for the treatment of lung, colon, and other tumor-types. 1

PI_NAMEs: GREGORY, RICHARD I. (contact)

PROJECT_TITLE: Role of the Epitranscriptome in Cancer


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: WHITE PLAINS

ORG_NAME: WINIFRED MASTERSON BURKE MED RES INST

PHR: Evidence is mounting that neuronal hyperexcitability during the progression of Alzheimer’s disease (AD), can initiate decades prior to canonical memory loss and associated neuropathology. This proposal will model the dynamic relationship between hyperexcitation/hyperarousal and protein build up of tau and amyloid to understand how selective brain areas, like the locus coeruleus, are impacted early in disease. It will also demonstrate how this can lead to hippocampal dysfunction causing cognitive loss and will attempt to reverse pathological phenotypes by treating proteostasis deficits and ameliorating early stage neuronal hyperexcitation.

PI_NAMEs: HUSSAINI, S. ABID  (contact);YU, HO WH

PROGRAM_OFFICER_NAME: THOMAS, CIBU PAUL

PROJECT_TITLE: The role of neuronal hyperexcitability and proteostasis in Alzheimer's disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


PHR: PROJECT NARRATIVE Our proposal seeks to understand the impact that recently announced changes to the Medicare Shared Savings Program will have on an accountable care organization’s (ACO’s) decision to participate, as well as the potential effects of these changes on care delivery, health outcomes, and spending. Findings from our study will be of value to policymakers and clinician leaders, providing them with actionable insights as they incorporate greater financial risk into the ACO model.

PI_NAMEs: HOLLENBECK, BRENT K. (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TITLE: Accelerating the Shift to Downside Risk in Medicare Accountable Care Organizations: Effects on Clinical Quality and Costs among Older Patients

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: PHYSIOLOGY

PHR: Epilepsy is a devastating disorder that affects millions of people in the US alone. In this project we propose to study the cause of a certain type of seizure disorder mediated by high levels of a protein called UBE3A in the brain. We will use genetically modified fruit flies and mice to manipulate different types of cells in the brain that express this protein that is responsible for the seizures and then find the proteins involved in this type of epilepsy.

PI_NAMEs: REITER, LAWRENCE T (contact);ZAKHARENKO, STANISLAV S

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TITLE: The role of UBE3A in gliopathic seizures

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_DEPT: BIOCHEMISTRY

PHR: NARRATIVE Psychostimulant use disorder accounts for a third of overdose deaths, however, currently there is no FDA- approved pharmacotherapy to treat it. Recent evidence suggests a role for diet and gut signaling in modulating the dopaminergic reward signaling and SUD behavior. I propose to use a recently developed amphetamine preference assay in Drosophila to identify the environmental factors, like dietary components, as well as signaling pathways that modulate this SUD-related behavior.

PI_NAMEs: TITOS VIVANCOS, IRIS  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TITLE: Mechanisms of diet modulating experience-dependent amphetamine preference

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ORG_CITY: BLACKSBURG

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: Toxoplasma replication is the underlying mechanism by which this parasite causes severe and life-threatening disease. The work proposed here seeks to define how the parasite forms a structure called the inner membrane complex, which is analogous to its skeleton. Data from these studies will also identify novel drug targets.

PI_NAMEs: BLADER, IRA J (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TITLE: The Organization and Function of the Toxoplasma Daughter Cell Scaffold

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)]


ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PI_NAMEs: PINTO, AMELIA KAHLER (contact)

PROJECT_TITLE: Changes in Cellular Metabolism Associated with Metabolic Syndrome Increase the Severity of Neurotropic Viral Infections


ORG_CITY: ROYAL OAK

ORG_NAME: WILLIAM BEAUMONT HOSPITAL RESEARCH INST

PHR: Project Narrative This application proposes to validate the robustness of Shutter-Speed Model (SSM) dynamic contrast- enhanced (DCE) MRI as a quantitative imaging biomarker for assessment of cancer therapy response in a multicenter prospective study, using the setting of breast cancer response to neoadjuvant chemotherapy as the clinical test platform. Validation of this quantitative imaging method in a multi-site and multi-MR scanner platform setting and making the associated software tools publicly available will accelerate the translation into clinical trials and, ultimately, clinical practice to improve prediction and evaluation of cancer therapy response for individual patients in the emerging era of precision medicine.

PI_NAMEs: HOLMES, JAMES H;HUANG, WEI  (contact);PARTRIDGE, SAVANNAH CORRINA

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TITLE: Multicenter Quantitative MRI Assessment of Breast Cancer Therapy Response

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This multicenter clinical trial will examine whether a vaccine (“Triplex”) for a common viral infection (cytomegalovirus [CMV]) will be safe, effective and elicit CMV-specific immunity, and decrease the need for toxic CMV antiviral therapy in liver transplant recipients who are at high risk for CMV infection. If shown to be effective, this vaccine could be used as a way to better prevent CMV infection in transplant recipients and other populations with weakened immune systems who are at risk for CMV infection.

PI_NAMEs: DIAMOND, DON J;FISHER, CYNTHIA E;LIMAYE, ABHIJIT PRAKASH (contact)

PROGRAM_OFFICER_NAME: HAYES, DEBORAH

PROJECT_TITLE: Cytomegalovirus (CMV) Vaccine in Orthotopic Liver Transplant candidates (COLT)


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Histone monoaminylation (i.e., H3 serotonylation and dopaminylation), in which the neurotransmitters are modification donors, is a newly identified epigenetic marker that plays an important role in regulating neuronal transcription. By applying chemical biology approaches, we recently discovered that the dynamics of histone monoaminylation (including installation, removal, and replacement) are regulated by a single enzyme, transglutaminase 2 (TGM2), and thereafter identified an unreported epigenetic marker (i.e., H3 histaminylation) that promotes neural rhythmicity. Our proposed research program will provide a chemical biology toolbox for investigating histone monoaminylation and elucidate its impacts on chromatin structure and function, which will build new pathophysiological connections between neuroscience, epigenetics, and psychology.

PI_NAMEs: ZHENG, QINGFEI  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Development of a Chemical Biology Toolbox to Investigate Histone Monoaminylation


ORG_CITY: AUGUSTA

ORG_NAME: CHARLIE NORWOOD VA MEDICAL CENTER

PHR: Pulmonary fibrosis is a devastating illness that involves progressive remodeling and scarring of lung tissue that can eventually lead to poor gas exchange. The incidence of idiopathic pulmonary fibrosis is increasing worldwide, including among Veterans, mortality rates are high, and the average life expectancy is 3 to 5 years after diagnosis. This proposed study will investigate a previously unrecognized mechanistic pathway that contributes to the development of pulmonary fibrosis and will identify potential targets for therapeutic intervention to reduce fibrosis.

PI_NAMEs: WATERS, CHRISTOPHER M (contact)

PROJECT_TITLE: Sex differences in ASK1-mediated pulmonary fibrosis


ORG_DEPT: PSYCHIATRY

PHR: Narrative This multi-site collaboration will assess pediatric, adolescent, and young adult survivors (PAYAS) of cerebellar medulloblastoma (MB) and the unique contributions of (1) Environmental resources (e.g., area deprivation, material hardships, caregiver capacity, school quality), (2) clinical factors (e.g., MB molecular tumor type, treatment level, age) and (3) individual genetic diathesis (i.e., targeted single nucleotide polymorphism variants (SNPs) using gene and RNA sequencing association), as independent risk factors for cognitive impairment (CI). Further, we will create a multi-domain risk algorithm, using the most sensitive predictors of CI across the three domains, in order to create a multifactorial measure that best captures the biopsychosocial markers of CI outcomes in PAYAS of MB. Consistent with the STAR Act of 2018 and the Precision Medicine Initiative, this research will inform the development of risk- adapted chemoradiation treatment and preemptive interventions to prevent, mitigate and manage CI to optimize outcomes and improve overall quality of life in PAYAS of childhood cancer.

PI_NAMEs: KING, TRICIA Z. (contact)

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TITLE: Outcomes in AYA survivors of pediatric medulloblastoma.


ORG_CITY: MADISON

ORG_NAME: WM S. MIDDLETON MEMORIAL VETERANS HOSP

ORG_STATE: WI

PHR: Hearing loss and tinnitus are the most common service-related disabilities for veterans. These disabilities span decades, conflicts, geographic location, and job descriptions. For those patients who have hearing loss too severe to benefit from hearing aids, cochlear implants offer a chance to regain some hearing and even understand speech without reading lips. However, current electrode technology cannot approach natural hearing. We propose applying living scaffold technology to the central and peripheral auditory system to create an implantable hearing device that provides more natural hearing than is possible with current technology. Living electrodes will be created by growing spiral ganglion neurons on to constructs designed to be implanted in the cochlea or auditory nuclei in the brainstem. These studies promise to deliver a significant advance in the ability to restore hearing to veterans, and people around the world.

PI_NAMEs: BRANT, JASON  (contact)

PROJECT_TITLE: Living electrodes for auditory rehabilitation.


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: HOOVER

ORG_NAME: MOREMME-JAVORE LLC

ORG_STATE: AL

PHR: PROJECT NARRATIVE Approximately 50% of post-menopausal women worldwide suffer from Vaginal Atrophy, a component of Genitourinary Syndrome of Menopause, which is a chronic, progressive condition occurring due to menopause- related estrogen deficiency. The work proposed in this application aims to optimize loading and release of Moremme’s natural, hormone-free bioactive gel formulations, assess biocompatibility in a human vaginal tissue model, and establish efficacy in a rodent model of Vaginal Atrophy. Our goal is to develop a safe, effective, hormone-free vaginal suppository as an alternate and more acceptable treatment option for women suffering from Vaginal Atrophy.

PI_NAMEs: AKANDE-DOKUN, JANET  (contact)

PROGRAM_OFFICER_NAME: FOX, JENNIFER THERESA

PROJECT_TITLE: Hormone-Free Prebiotic Muco-Adhesive Gels To Treat Vaginal Atrophy in Post-Menopausal Women

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-S(10)B]


ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE This proposal will use genome-wide approaches to investigate transcription-coupled DNA repair in eukaryotes. Studies proposed in this application will help us understand mechanisms of the neurological disorder Cockayne syndrome (CS) and cancer mutagenesis.

PI_NAMEs: MAO, PENG  (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TITLE: Mechanism of Transcription-coupled DNA Repair and its Impact on Cancer Mutations

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: LA CROSSE

ORG_NAME: VITERBO UNIVERSITY

PHR: Project Narrative This project addresses a critical limitation in social communication rehabilitation for adults with traumatic brain injury, namely the lack of practical, valid, and person-centered clinical assessment tools. This project will address this need by integrating rehabilitation and communication theory with stakeholder perspectives to develop, refine, and evaluate the first social communication clinical assessment tools that are short, valid, and guide person-centered treatment. Valid, reliable, and person-centered social communication assessment is the first step to effective communication rehabilitation.

PI_NAMEs: BYOM, LINDSEY JACQUELYN (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TITLE: Development and Evaluation of a Clinical Assessment Tool of TBI-Related Social Communication

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ORG_CITY: WASHINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: HOWARD UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Biological patterning relies on the coordination of cell-cell communication events across large and small distances, and defects in patterning can lead to human disorders and disease. Cytonemes are one example of an active cell process that coordinates cell signaling for many patterning events during vertebrate and invertebrate development. The goal of this work is to understand both how cytonemes are regulated at the cellular scale and how they contribute to the overall progression of patterning.

PI_NAMEs: HUNTER, GINGER LORAINE (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TITLE: Mechanisms of Cellular Morphogenesis that Coordinate Signaling during Tissue Patterning

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ORG_NAME: MORGRIDGE INSTITUTE FOR RESEARCH, INC.

PHR: This work will increase understanding of developmental regulation during vertebrate tissue regeneration, and provide important perspective for comprehending, and perhaps changing, the existing limitations in regenerative capacity of human tissues.

PI_NAMEs: POSS, KENNETH D (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TITLE: Regulation of Appendage Regeneration in Zebrafish

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


ADMINISTERING_IC: AA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: EUGENE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE Heavy and frequent alcohol use remains a key public health concern, particularly among young adults. The proposed work will collect intensive momentary assessment data to examine associations between higher-risk alcohol use episodes (binge, high-intensity, blackout drinking) and multiple indices of next-day (post- intoxication) cognitive functioning. By identifying the acute impacts of varying levels of alcohol use intensity on next-day cognitive functioning as well as the day- and person-level characteristics that moderate these associations, our findings will have critical implications for the role of alcohol use on everyday cognitive functioning and highlight subgroups most in need of monitoring and early intervention.

PI_NAMEs: LINDEN-CARMICHAEL, ASHLEY NICOLE (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TITLE: An Ecological Investigation of Acute Next-Day Effects of Alcohol Use on Daily Cognitive Functioning

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Physical activity is a modifiable health behavior that is among the most promising strategies for slowing cognitive decline and preventing Alzheimer’s Disease and related dementias. Although many strategies have been developed to promote physical activity in midlife and older adults, little is known about how to maintain behavior change following the end of a behavioral intervention. This Center will apply an experimental medicine approach to develop interventions that engage the targets that support long-term maintenance of behavior change and enhance cognitive function.

PI_NAMEs: CONROY, DAVID E. (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TITLE: Roybal Center for Promoting Adherence to Behavior Change and Enhancing Cognitive Function


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative The proposed study is focused on defining the aging-related metabolite alteration that influence microbiome composition and activating pro-inflammatory signaling which will help in understanding how the aging microbiome relates to the causes and pathophysiology of age-related chronic inflammation.

PI_NAMEs: LI, XIN  (contact);SAXENA, DEEPAK

PROGRAM_OFFICER_NAME: FLORES, ROBERTO L

PROJECT_TITLE: Succinate triggers gut dysbiosis and activates SUCNR1 to enhance inflammaging


ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PI_NAMEs: SOKOLOVSKY, ALEXANDER WILLIAM (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TITLE: Using wearables and EMA to examine the links between cannabis and depression

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-3 (C2)]


ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Chronic pain, a common and distressing complication of advanced cancer, is commonly treated with analgesics with minimal access to comprehensive biopsychosocial pain management approaches. Aligning with NCI’s mission to advance scientific knowledge to help patients live longer, healthier lives, this K08 proposal seeks to improve cancer patients’ pain self-management by adapting and integrating cognitive behavioral therapy for pain into an existing mHealth intervention designed to optimize pharmacologic management (e.g. daily pain/opioid monitoring and tailored advice) for patients with advanced cancer. This integrated psychological and pharmacologic mHealth intervention has strong potential to improve cancer pain outcomes and to readily disseminate pain management support and alleviate pain for a wide range of patients with advanced cancer.

PI_NAMEs: HILTON, DESIREE R (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TITLE: Integrating pain-CBT into an mHealth analgesic support intervention for patients withchronic pain from advanced cancers

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


PI_NAMEs: BRENNAN, DANIEL CONLON;FISHER, CYNTHIA E;LIMAYE, ABHIJIT PRAKASH (contact)

PROGRAM_OFFICER_NAME: GALIVO, FEORILLO HERRERA

PROJECT_TITLE: Kidney transplant Preemptive therapy or Prophylaxis (KPoP) for CMVPreventionin D+R- Recipients


ADMINISTERING_IC: IP

IC_NAME: NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: CHU, HELEN YING-HUI (contact)

PROJECT_TITLE: IP24-045, SEAPREP:  Seattle Pandemic Preparedness Cohort


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Preeclampsia and (NAFLD) that prospectively population maternal (PE) is a leading cause of maternal morbidity and mortality in the United States there is an urgent ongoing need to identify its risk factors. Nonalcoholic fatty liver disease is the most common liver disease among women and leads to lipid dysregulation may contribute to endothelial cell dysfunction that characterizes PE. This project will evaluate the association between NAFLD and PE in a diverse patient and define relevant NAFLD-associated lipid changes that may contribute to endothelial dysfunction during pregnancy.

PI_NAMEs: KUSHNER, TATYANA  (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TITLE: Nonalcoholic fatty liver disease, associated lipidomic changes, and preeclampsia risk

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: Newark

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE  Fragility fractures are common injuries that have direct implications on patient function and mortality. This proposal uses bioresorbable implants to investigate the effects of gradual introduction of micromotion within the fracture callus in the presence of healthy and compromised bone. These findings will provide new insights into the role of mechanotransduction and clinical standards of care, while establishing a research framework for developing and optimizing implant designs that will improve patient outcomes.

PI_NAMEs: HAST, MICHAEL WILLIAM (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TITLE: Modifying fragility fracture healing using a gradient-based mechanotransduction fixation approach

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ORG_CITY: LOUISVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

PHR: NARRATIVE Antimicrobial resistance is an increasing public health threat in the United States and there is an urgent need to develop novel antimicrobials. The work proposed here will improve our fundamental knowledge of a key antibiotic target, the ribosome, and potentially reveal new avenues for antimicrobial development.

PI_NAMEs: RAMSEY, KATHRYN MARY (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TITLE: Bacterial ribosome heterogeneity and gene expression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


ADMINISTERING_IC: ES

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: COLLEGE STATION

ORG_DEPT: GENETICS

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE The health effects associated with low-dose arsenic are controversial, and our knowledge of the molecular mechanisms underlying different individuals’ susceptibility to low-dose arsenic is limited. The proposed study will bring mechanistic insights to arsenic, aquaporin 3–induced DNA damage and mutations, highlighting the importance of studying the mechanisms underlying individual susceptibility to low-dose arsenic. This project will also identify potential early genomic biomarkers to predict long-term arsenic toxicology.

PI_NAMEs: XIA, JUN  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TITLE: The Role of Aquaporin 3 in Arsenic-Induced DNA Damage and Mutagenesis


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative High risk forms of acute myeloid leukemia arise when hematopoietic progenitors acquire stem cell-like gene expression programs but the molecular mechanisms underlying these transcriptional changes remain incompletely defined. Recently, I uncovered an essential gene expression program regulated in part by the transcription factor MECOM that drives leukemia and is associated with very poor patient outcomes. Now I seek to define critical co-factors that help regulate the expression of these genes and identify and functionally characterize the indispensable downstream effectors of MECOM signaling in AML to uncover new therapeutic vulnerabilities in high-risk leukemia.

PI_NAMEs: VOIT, RICHARD A (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TITLE: Uncovering therapeutic vulnerabilities in AML through mechanistic interrogation of MECOM activity


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: COLUMBIA

ORG_NAME: SC STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: SC

PHR: Project Narrative - SCRRT Maintenance Track  FOA Number: RFA-FD-23-019; Application ID: 1417421  Research and Related Other Project Information Form, Field #8 By the end of our current five-year cooperative agreement, the South Carolina Department of Health and Environmental Control (DHEC), with assistance from the South Carolina Department of Agriculture (SCDA), will have fully developed the South Carolina Rapid Response Team (SCRRT) based on national standardized objectives. If awarded this cooperative agreement, DHEC will improve our methods for protecting public health by collaborating with SCDA to successfully maintain the SCRRT and improve our processes over the three-year period. The SCRRT, a multi-disciplinary, multi-agency team composed of DHEC, SCDA, and other key state agencies, will work collaboratively to respond to all human and animal food (HAF) incidents and outbreaks to secure the safety of South Carolina’s food supply.

PI_NAMEs: DORTON, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: ANDREWS, THANH

PROJECT_TITLE: Continuation of Cooperative Agreement between U.S. Food and Drug Administration and S.C. Department of Health and Environmental Control (DHEC) for RRT Maintenance.


ORG_CITY: Aurora

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: This project will use measurements of altered mTOR signaling pathways in neural cell types of the human brain and address how these abnormalities impact various developmental stages, spanning early neural progenitor cells to neurons and glia found in the postnatal brain, using patient-derived cells and models.

PI_NAMEs: ESS, KEVIN C;IHRIE, REBECCA A (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TITLE: Identifying mTOR Dependent Periods During Brain Development

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF-R]


ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Mitochondrial function underlies a broad spectrum of health and disease conditions but many of the mechanisms remain unknown. This study will provide novel knowledge of mitochondrial function in the aspect of mitochondrial proton leak, and its key mechanisms. Moreover, we will provide a novel group of drugs that modulate mitochondrial proton leak to regulate mitochondrial function.

PI_NAMEs: ZHANG, HUILIANG  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TITLE: Deciphering the mitochondrial proton leak

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ORG_CITY: MADISON

PHR: PROJECT NARRATIVE The discoveries we make will continue to inform the fundamental biology of heart regeneration, and they will directly relate to ideas and methods to enhance regeneration and reduce the incidence of heart failure in humans. They are also likely to extend beyond cardiovascular biology and have relevance to the repair of other tissues.

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TITLE: Leveraging zebrafish models to dissect and enhance heart regeneration


ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE Pituitary neuroendocrine tumors (PitNETs) are rare, occurring in approximately 10 per million individuals per year. Despite decades of research, current treatments are suboptimal, and the development of targeted therapies is challenging due to the limited knowledge of PitNET tumor cellular and molecular complexity. The interdisciplinary team science RC2 BioPitNeT project will develop a collection of novel research tools and resources that will enable the rapid and accurate generation of knowledge required for the development of treatment, and prevention of recurrent PitNETs that will ultimately improve the quality of life for patients

PI_NAMEs: LITTLE, ANDREW SCOTT;ZAVROS, YANA  (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TITLE: The National Biorepository and Resource for Pituitary Neuroendocrine Tumor Translational Research (BioPitNeT)


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: BOZEMAN

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: Project Narrative This research project builds on our current community partner relationships and uses a Community-Based Participatory Research (CBPR) framework to culturally adapt and test the feasibility of a Behavioral Activation and Therapeutic Exposure for Grief (BATE-G) intervention among American Indian and Alaska Native (AI/AN) people who are experiencing impairing grief-related symptoms diagnosed as Persistent Complex Bereavement Disorder (PCBD). BATE-G employs trained AI/AN community paraprofessionals to deliver intervention content via telehealth, increasing access to culturally responsive evidence-based treatments for this often-underserved population. This project will also contribute to the research and training development of an early career investigator whose career goals center around understanding and addressing health inequalities in underserved communities with a focus on trauma and grief.

PI_NAMEs: GAMEON, JULIE A (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TITLE: Cultural Adaption of Behavioral Activation and Therapeutic Exposure for Grief Among American Indian People


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: COLLEGE PARK

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Frontotemporal dementia is the most common form of dementia for people under age 60, but curative treatment is currently unavailable due to our limited understanding of the molecular etiology. This proposed research aims at developing mass spectrometry-based strategies to determine how GRN mutations, which result in progranulin deficiency, impair lysosomal functions and eventually lead to frontotemporal dementia. The molecular insights gained from this research will decipher the relationship between progranulin, lysosomes, and frontotemporal dementia, providing potential therapeutic target to develop disease- modifying treatments for FTD.

PI_NAMEs: HAO, LING  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TITLE: Development of Mass Spectrometry Strategies to Decipher Dynamic Lysosomal Dysfunctions in Frontotemporal Dementia

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Advances in high-resolution mass spectrometry (HRMS) offer unique opportunities to study the human exposome and the development of adverse health outcomes. Despite advances in non-targeted analysis, the number of confirmed chemicals remains fairly limited compared to the number of detected chemical features. The goal of this proposal is to develop novel computational methods to derive chemical structures and apply them to a large dataset of HRMS data from blood samples of pregnant women to study the influence of the exposome on pregnancy outcomes with a focus on preterm birth.

PI_NAMEs: ABRAHAMSSON, DIMITRI  (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TITLE: Non-target analysis of maternal and cord blood samples: Advancing computational tools and discovering novel chemicals

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: The eye is 10 times more susceptible to exposure to vesicant chemical warfare agents than other organs, for example, the skin or the respiratory tract. The lack of molecular understanding of the underlying mechanism driving the ocular tissue pathobiology in victims of vesicant exposures impedes the development of effective medical countermeasures. In this proposal, we attempt to uncover the key molecular signaling controlling acute and chronic stages of ocular injury in animals with direct ocular exposure to vesicants.

PI_NAMEs: GORBATYUK, MARINA  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TITLE: The mechanism of vesicant-induced ocular injury


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE FOR OVERALL COMPONENT Echinobase is a model organism knowledgebase for the echinoderm research community. Genomic resources and links out to other databases are provided through a design that facilitates rapid user access to information. Features have been guided by the community and developed upon FAIR principles.

PI_NAMEs: ETTENSOHN, CHARLES A.;HINMAN, VERONICA FRANCES (contact);VIZE, PETER D

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TITLE: Enhanced Echinobase: A Community Genomics Research Resource For The Future


ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE The outcomes and treatment response of head and neck cancer varies by sex and menopausal status, with premenopausal women demonstrating the best response to therapy, including immunotherapy. Our preclinical data identified regulatory T cells (Tregs), dendritic cells (DCs), and high endothelial venules (HEVs) as target populations mediating estrogen's response to therapy. In this proposal, we examine how estrogen regulates these cellular targets to modulate the sexually dimorphic effect of therapy.

PI_NAMEs: KARAM, SANA D (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TITLE: Sexual dimorphism and the immuno-modulatory role of estrogen signaling in HNSCC

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIR-W(01)Q]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Human non-homologous end joining (NHEJ) pathway represents the predominant repair mechanism for dealing with double strand breaks (DSBs) throughout the entire cell cycle. Its understanding is of great importance for cancer etiology and cancer therapy, due to its significant role in maintaining genome stability and protecting cells from becoming cancerous. Through structural and functional studies, we seek to define the complex molecular mechanisms of NHEJ so that they may be targeted to develop improved approaches to antitumor therapy.

PI_NAMEs: HE, YUAN  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TITLE: Structure and Mechanism of Non-Homologous End Joining

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE This application aims at demonstrating that adrenal development and lifelong synthesis of glucocorticoid and mineralocorticoid hormones in the offspring is determined in part by a maternal influence in bony vertebrates. This application will advance our understanding of vertebrate endocrinology by focusing on the novel regulation of adrenal steroidogenesis by the mother’s skeleton. This project will determine genetically, and in vivo, all aspects of this regulation during development and after birth.

PI_NAMEs: YADAV, VIJAY K (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TITLE: Regulation of adrenal development and function by the mother's skeleton

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative The proposed research is relevant to public health because it will provide new materials and technology to treat hyperphosphatemia. Hyperphosphatemia is common among patients with advanced chronic kidney disease and kidney failure and is not efficiently treated with dialysis and oral phosphate binders. The properties of the complexes and the materials will be optimized to ensure their safety and efficacy in blood.

PI_NAMEs: PIERRE, VALERIE C. (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TITLE: Immobilized phosphate receptors for the treatment of hyperphosphatemia

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE Expeditious diagnosis and effective treatment are essential for the positive long-term outcomes for patients with Cushing’s Disease (CD). Effective treatment of recurrence of disease remains a challenging task for endocrinologists and neurosurgeons. The proposed research will allow us to identify novel therapeutic approaches to effectively treat ACTH-secreting pituitary adenomas in patients with CD by targeting the tumor directly.

PROJECT_TITLE: Development and Standardization of a Novel Pituitary Adenoma Organoid Model for the Study and Treatment of Cushing's Disease

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: CK

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: KINSHASA

ORG_COUNTRY: CONGO DEM REP

ORG_FIPS: CG

ORG_NAME: KINSHASA SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative Zoonotic diseases like Monkeypox and Ebola virus disease are a significant public health threat in Democratic Republic of the Congo (DRC) and have a high risk of international exportation. This project aims to improve the ability of DRC to respond to zoonotic diseases by developing rigorous surveillance systems, investigating medical countermeasures and clinical treatments, identifying key risk factors in primary transmission of disease, and creating a resilient interdisciplinary public health workforce.

PI_NAMEs: KABA, DIDINE KINKODI (contact)

PROJECT_TITLE: RFA-CK-22-001, Investigation of Monkeypox and Other Zoonotic Diseases in the Democratic Republic of the Congo (DRC) - 2022


ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PI_NAMEs: BURNS, SUZANNE  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TITLE: Cognitive strategies for Optimizing Brain Health and Managing Transgenerational Vascular Risk Factors Post-Stroke


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: RICHARDSON

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: Project Narrative  There is growing awareness of the importance of sex differences in the auditory system, particularly susceptibility to otological disorders. The proposed study will determine molecular mechanisms for female hearing loss. This study is relevant to public health because the knowledge gained from the studies will guide future clinical efforts to develop diagnostic tools for defining underlying causes of female hearing loss.

PI_NAMEs: HU, BO HUA  (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TITLE: Novel mechanism for sex differences in hearing loss

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative Experiences of loneliness are prevalent among older adults living in the community. The proposed study aims to develop, deploy, and validate a smart speaker-based in-home loneliness assessment system for community-dwelling older adults. This study is highly relevant to public health as it explores the innovative use of commercially available digital technologies to enable a remote loneliness assessment for older adults, which will move assessment out of the clinic and into older adults’ everyday lives to identify lonely individuals early enough to intervene before negative health outcomes occur.

PI_NAMEs: CHUNG, JANE  (contact);NADEEM, TAMER

PROGRAM_OFFICER_NAME: PLUDE, DANA JEFFREY

PROJECT_TITLE: HomePal: Developing a Smart Speaker-Based System for In-Home Loneliness Assessment for Older Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-X(90)S]


PHR: PROJECT NARRATIVE With growing concerns regarding the environment and sustainability in the pharmaceutical industry, synthesis of drugs using electricity is emerging as a green and advantageous alternative to traditional synthetic methods because it can cut down on the usage of chemicals, reduce waste, and offer improvements in cost, safety, and sustainability in pharmaceutical production. The first step towards the long-term vision of electrically-driven green synthesis of drugs is to build up an electrosynthetic reaction library. The goal of this proposal is to establish alternating current electrolysis, which uses alternating current to drive chemical reactions, for new reactivities in organic synthesis.

PI_NAMEs: LUO, LONG  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Alternating Current Electrolysis for Organic Synthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Pathological aggregation of the protein tau is a hallmark of Alzheimer’s disease (AD) and other tauopathies. This proposal aims to dissect the mechanism by how the presynaptic protein Bassoon works as a scaffold to stabilize and facilitate the trans-synaptic spreading and neurotoxicity of a tau pathological-seed. This work may provide important information that will increase our understanding in the mechanisms and the nature of the tau species involved in the phenomenon of propagation and neurodegeneration.

PI_NAMEs: LASAGNA-REEVES, CRISTIAN  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TITLE: Tau-seed protein interactome and its role in neurodegenerative tauopathies


PHR: PROJECT NARRATIVE An inability to maintain genome integrity is associated with a loss of cellular homeostasis and several human diseases including cancer. Histone H2A variants are emerging as key components of chromatin that function in genome integrity that are often dysregulated in cancer. Our goal here is to identify how histone H2A variants collaborate with PARP1 and KDM5A to promote DNA repair and genome integrity pathways, including how their dysregulation may be targeted therapeutically using radiotherapy and PARPi.

PI_NAMEs: MILLER, KYLE M (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TITLE: Shaping DNA Damage Response Networks Via Histone H2A Variants

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: 8. PROJECT NARRATIVE This study proposes to promote sustained viral suppression by building an optimized intervention for people who inject drugs and are living with HIV on the U.S.-Mexico Border. Interventions have shown success in achieving shorter-term viral suppression outcomes among people who inject drugs, but we propose to identify the intervention components that derive the greatest benefits and impact on viral suppression with the goal to promote long-term viral suppression. The intervention is being implemented in a real-world setting and with real-world constraints in place to facilitate the greatest possibility of scalability.

PI_NAMEs: LECHUGA, JULIA  (contact);SAUCEDA, JOHN ANDREW

PROGRAM_OFFICER_NAME: MANDLER, RAUL N

PROJECT_TITLE: Optimizing a bio-behavioral intervention to promote viral suppression among HIV+ people who inject drugs on the U.S.-Mexico border

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Nanoparticle-based therapies have many potential advantages for treating cancer, but there are currently no clinical biomarkers to predict which patients are most likely to benefit from nanotherapies. This proposal seeks to validate the solute carrier SLC46A3 as a regulator of phospholipid metabolism in cancer cells and the first predictive biomarker for liposomal nanoparticle delivery.

PI_NAMEs: STRAEHLA, JOELLE PAYNE (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: Investigating SLC46A3 as a negative regulator of nanoparticle drug delivery

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE The Massachusetts HIV/Justice Research Network will develop and study the outcomes and implementation of an intervention to increase access to carceral HIV healthcare. Findings will have implications for HIV treatment and prevention to end the HIV epidemic in jail populations.

PI_NAMEs: EVANS, ELIZABETH A.;WURCEL, ALYSSE GAIL (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TITLE: Massachusetts HIV and Justice-Involved Populations Research Network


ORG_CITY: WHITE PLAINS

ORG_NAME: WINIFRED MASTERSON BURKE MED RES INST

ORG_STATE: NY

PHR: PROJECT NARRATIVE Understanding how specific neurons in a selectively vulnerable region such as the entorhinal cortex are affected is critical to unraveling the mechanisms underlying Alzheimer's disease onset. Using in-vivo single-unit electrophysiology recordings and optogenetics we will identify if excitatory neurons or inhibitory neurons or both are more vulnerable to Alzheimer’s disease pathologies. We will use chemogenetic approach to reduce pathology and restore neuronal function.

PI_NAMEs: HUSSAINI, S. ABID  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TITLE: Assessing Neuronal Vulnerability in the Entorhinal Cortex due to Alzheimer's Disease Pathology

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PI_NAMEs: CHANG, TIMOTHY S (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TITLE: Core D: Data


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: Project Narrative: At the end of the project, we will have enhanced the website and a printout format that the Scientific Registry of Transplant Recipients will use to provide information to the public. We will help patients choose transplant centers by using report cards that provide the new metric, survival rate since listing. The enhanced patient centered report card will work towards improving a broad set of patient-centered outcomes, allowing patients to effectively navigate the health system of transplant centers with varying outcomes, creating greater knowledge, satisfaction with the transplant center selection process, improving access to the waiting list and, in the long-run, improving outcomes.

PI_NAMEs: ISRANI, AJAY K (contact)

PROGRAM_OFFICER_NAME: SIMPSON, MATTHEW

PROJECT_TITLE: New Patient-centered Metric for Transplant Center Report Cards

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE The proposed research is relevant to public health because the mitonuclear interaction is altered is altered in a number of different diseases including cancer, obesity, neurodegeneration, and aging. Given that the mechanisms regulating mitonuclear interaction are conserved from yeast to humans, understanding this genetic network may allow us to identify new therapeutic targets for potential interventions for human diseases associated with harmful consequences of mitochondrial dysfunction. Therefore, the research is relevant to NIGMS’s mission in supporting basic research that increases understanding of biological processes and laying the foundation for advances in disease treatment.

PI_NAMEs: KAYA, ALAATTIN  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TITLE: The role of mito-nuclear communication in the adaptation to mitochondrial dysfunction and stress resistance


ORG_CITY: STONY BROOK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative  Our goal is to elucidate how biophysical inputs from tissue microenvironments program molecular and cellular interactions and drive phenotypic state transitions.

PI_NAMEs: MAK, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TITLE: TRANSFER GRANT: Systems Biophysics of Multiscale State Transitions in Cells and Tissues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Depression is a leading cause of disability worldwide and current treatments, such as psychotherapy and medication, are ineffective for many people, leading to a high global burden of depression. This project will investigate the efficacy of a 16-week Resistance Exercise Training (RET) program for treatment of Major Depressive Disorder via improving cerebrovascular mechanisms and using machine learning to inform future precision medicine approaches by modeling changes in depression outcomes, cerebrovascular function, and variation in adherence. If efficacy is confirmed, this highly translatable, accessible, low-cost treatment would add a novel behavioral treatment option for MDD while the machine learning modeling will independently help to improve treatment prescription and optimization for people with depression and other serious mental illnesses.

PI_NAMEs: MEYER, JACOB D (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TITLE: Resistance Exercise to Treat Major Depression via Cerebrovascular Mechanisms: Confirming Efficacy and Informing Precision Medicine


ORG_CITY: DALLAS

ORG_DEPT: PEDIATRICS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Individuals with neurofibromatosis type 1 (NF1) have a dramatically increased risk of developing malignant peripheral nerve sheath tumors (MPNST), a leading cause of death for NF1 patients. This project will investigate cellular and molecular mechanisms from a developmental defect-induced nerve injury to malignant transformation during NF1-MPNST formation.

PI_NAMEs: ZHU, YUAN  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TITLE: Developmental Origin, Injury and Epigenomic Regulation of NF1-Associated Peripheral Nerve Sheath Tumors

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative  Females experience temporomandibular disorders at higher rates compared to males, and African Americans have higher temporomandibular disorder incidence, yet lower prevalence compared to white Americans; the causes of these sex and race disparities remain largely unknown. The goal of the proposed study is to investigate how sex- and race-specific differences in human temporomandibular lateral capsule-ligament (LCL) complex properties may affect the temporomandibular joint loading environment. Sex- and race-specific differences in human LCL complex properties could result in a temporomandibular loading environment with variable resiliency and sensitivity to pathologic displacements between sexes and racial groups, creating disparities in temporomandibular joint disorder incidence and prevalence.

PI_NAMEs: HILL, CHERICE NATASHA (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TITLE: Tissue structure and mechanical function relationships of the human temporomandibular lateral capsule-ligament: Investigation of sexual and racial dimorphisms

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PI_NAMEs: STEPHENSON, KATHRYN ELAINE (contact)

PROJECT_TITLE: IP24-045, A Prospective Observational Study of Respiratory Virus Epidemiology in the Greater Boston Area


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PI_NAMEs: LAURENT, LOUISE CHANG (contact)

PROJECT_TITLE: IP24-045, PREVENT: Preparedness through Respiratory Virus Epidemiology and Community Engagement


ORG_NAME: UNIVERSITY OF WASHINGTON

PI_NAMEs: CHU, HELEN YING-HUI (contact)

PROJECT_TITLE: IP24-045, SEAPREP:  Seattle Pandemic Preparedness Cohort


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: HYATTSVILLE

ORG_NAME: MEDSTAR HEALTH RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE The precise aspects of dysglycemia and glucose homeostasis that drive the risk of Alzheimer’s disease and Alzheimer’s disease related dementias are unknown, hampering development of successful prevention strategies. The proposed research will leverage wearable technology to investigate the association of glucose homeostasis, from continuous glucose monitors, with incident neurocognitive indicators of Alzheimer’s disease and Alzheimer’s disease related dementias in the Multi-Ethnic Study of Atherosclerosis. This study will suggest new mechanisms of Alzheimer’s disease and Alzheimer’s disease related dementia development, identify new primary and secondary prevention targets, and have the potential to change clinical care

PI_NAMEs: MONGRAW-CHAFFIN, MORGANA LEE (contact)

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TITLE: Glucose homeostasis and the risk of Alzheimer's disease and Alzheimer's disease related dementias in the Multi-Ethnic Study of Atherosclerosis

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative We have recently associated telomere biology disorders (TBD) and gain-of-function germline RPA1 mutations. The molecular and functional consequences of these mutations on telomere maintenance and hematopoiesis is not understood. The proposed studies will use biochemical methods and iPSC disease model to establish the molecular mechanism by which gain-of-function RPA1 mutations cause telomere dysfunction while using in vivo murine system to determine the functional consequence.

PI_NAMEs: SHARMA, RICHA  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TITLE: Consequences of gain-of-function RPA1 mutations on telomere function and hematopoiesis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

PI_NAMEs: BOYCE, ANDREW  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TITLE: Sex differences and spreading depolarization preconditioning in sub-cortical stroke


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative The proposed research is relevant to public health because substance use disorders (such as opioids, tobacco, and alcohol) are common, costly, and contribute to poor health outcomes. We are proposing the development of a method that helps researchers identify individuals with complex variations of these disorders in large data sets linked to genetic data in hopes of finding novel prevention and treatment interventions. The proposal is relevant to the National Institute on Drug Abuse’s emphasis on “…supporting and conducting basic and clinical research on drug use…and the underlying neurobiological…mechanisms involved.”

PI_NAMEs: JEFFERY, ALVIN DEAN (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TITLE: Framework to Accelerate Substance Use Disorder Genetic Studies through Customizable, EHR-Based Precision Phenotyping


ORG_CITY: AMHERST

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE Our research program will uncover important signals regulating RNA modifiers required for mitochondrial gene expression. RNA modifiers are associated with severe mitochondrial diseases, such as mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS); however, the cause for this link remains unclear. The central goal of this grant is to reveal how dysregulated RNA modifiers can contribute to the basic molecular mechanisms driving disease-relevant mitochondrial RNA processing pathways.

PI_NAMEs: PILLON, MONICA  (contact)

PROJECT_TITLE: New Mechanisms of the Pseudouridine Synthase Module in Mitoribosome Assembly

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: TALLAHASSEE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: PROJECT NARRATIVE: Current antiretrovirals, although effective in controlling HIV-1 infection, do not cure the disease. Antiretroviral drugs blocking essential functions of the viral protein Nef, if developed successfully, may revitalize immune de- fense mechanisms and thus open up the possibility for a cure. This project is designed to develop such an- tiretroviral therapeutics in a novel and promising format, namely cyclic peptides.

PI_NAMEs: FASAN, RUDI ;GUATELLI, JOHN C.;JIA, XIAOFEI  (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TITLE: Developing Cyclopeptide Nef Inhibitors to Facilitate HIV-1 Eradication

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Three-dimensional ultrasound imaging is an important clinical tool for disease diagnosis as well as providing guidance for interventional and surgical procedures. At present, existing three-dimensional ultrasound imaging technologies are not widely accessible, difficult to use, and do not provide sufficient imaging functionality to meet the clinical needs. To fill the gap, we propose to develop a new three-dimensional ultrasound imaging solution that is accessible, functional, user-friendly, low-cost, and compatible with most existing ultrasound imaging systems in the clinic.

PI_NAMEs: SONG, PENGFEI  (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TITLE: A novel transducer clip-on device to enable accessible and functional 3D ultrasound imaging

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: BOCA RATON

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

PHR: The proposed work is relevant to public health because the discovery of molecular mechanisms of ribosome stalling regulation in Huntington disease is ultimately expected to increase understanding of the neuronal vulnerability in diseases such as Parkinson disease, as well as provide framework for developing novel therapeutic strategies, based on mechanisms-based approaches. Thus, the proposed research is relevant to the part of NIH's mission that pertains to acquiring basic insights that will aid to lessen the pain of human of disability.

PI_NAMEs: SUBRAMANIAM, SRINI  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TITLE: Mechanisms of Translational Dysregulation in Huntington Disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: BLACKSBURG

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: The protozoan parasite Toxoplasma gondii latently infects 11-22% of Americans and can cause disease in immunocompromised patients and fetuses. As the parasite traffics through the body where it encounters diverse environment that it must adapt to or will die. The work proposed here is focused on learning how the parasite adapts to these environments with the ultimate goal of developing new therapies and treatments.

PI_NAMEs: BLADER, IRA J (contact);WEST, CHRISTOPHER M.

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TITLE: Protist Oxygen Sensing in Human Disease Protist Oxygen Sensing in Human Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-L(02)]


PHR: Project Narrative Atropisomerism is a dynamic type of chirality that is ubiquitous in modern drug discovery. Our research program revolves arounds exploiting the conformational space about atropisomeric axes to program target selectivity into promiscuous small-molecules, leading to compounds with fewer off-target effects as leads towards safer therapeutics and more precise tool compounds. Our research program also strives to develop enabling synthetic methodologies that allow for facile access to pharmaceutically relevant atropisomeric scaffolds in enantiopure form.

PI_NAMEs: GUSTAFSON, JEFFREY LOUIS (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: MIRA: Atropisomerism as an inspiration for drug discovery and new chemistry


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Within adipose tissues reside adipocytes with divergent functions, including distinct adipocytes that favor energy storage and others that dissipate energy. The balance of these different types of adipocytes has broad implication for metabolism and general health. This project is aimed at elucidating the pathways and unraveling the molecular mechanisms that distinguish the formation of different types of adipocytes.

PI_NAMEs: FELDMAN, BRIAN J (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TITLE: Molecular responses and physiological implications to systemic stimuli in adipocyte progenitor cells

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Narrative The proper alignment of internal circadian clocks with the 24-hour rhythm of the environment is critical for human health. A central goal of chronobiology is to understand the network properties of brain’s master clock and its modulation by environmental cues. Here we use Drosophila melanogaster, an organism that continues to enrich and inform our understanding of circadian timekeeping in the brain, to understand the signals neurons use to create an internal sense of time and how the microanatomical structures of neuronal clocks support robust circadian timekeeping and the proper synchronization with the environment.

PI_NAMEs: SHAFER, ORIE T (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TITLE: Micro-Anatomical Mechanisms of Neuronal Circadian Timekeeping, Output, and Entrainment

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ORG_CITY: CHICAGO

ORG_NAME: COOK COUNTY HEALTH AND HOSPITAL SYSTEM

ORG_STATE: IL

PHR: PROJECT NARRATIVE The purpose of this proposal is the renew the Minority-Underserved NCI Oncology Research Program at John H. Stroger, Jr. Hospital of Cook County in Chicago. The continuation of this valuable program is critically important to our minority patient population as it offers access to cancer care strategies that would not otherwise be available at our safety-net institution. It also contributes to the diversity of the study population in the NCTN.

PI_NAMEs: TAMKUS, DEIMANTE  (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TITLE: Stroger Hospital of Cook County (SHCC) MU-NCORP


ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Transcriptional regulation represents a major control mechanism of gene expression in eukaryotes. Cell-specific expression of ~20,000 genes in human cells requires hundreds of protein factors acting in a multistep manner. Through structural and functional studies, we seek to define the complex molecular mechanisms of gene transcription derived by different RNA polymerases at distinct regulatory steps.

PI_NAMEs: HE, YUAN  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TITLE: Structure and Mechanism of Eukaryotic Transcription Regulation

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Discovery of human metapneumovirus epitopes Our lab has established methods to discover human MHC-I and MHC-II epitopes using HLA-transgenic mice and human PBMCs. We propose to apply these methods to human metapneumovirus (HMPV) to discover HLA-restricted T cell epitopes recognized by CD4+ and CD8+ T cells. These tools will be needed to understand human immune responses to both natural infection and vaccines against this important human respiratory pathogen.

PI_NAMEs: WILLIAMS, JOHN V. (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


ED_INST_TYPE: HOSPITALS

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative Our goal is to develop a novel non-invasive, safe, sensitive, and specific methodology to monitor genetically altered human immune cells, called chimeric antigen receptor (CAR) T cells, after they have been transferred into patients to treat cancer. We have developed a DOTA antibody reporter, which binds to a clinically employed radiometal complex (DOTA), and we propose to use this tool for tracking transfused CAR T cells to determine their location and study their functionality, and in case of imminent treatment failure, to exploit these engineered T cells to deliver a deadly payload to the tumor with the goal of improving the anti-tumor efficacy of CAR T-cell therapy. By combining next-generation armored CAR T cells with molecular imaging and targeted radionuclide therapy, this project has the potential to significantly endow these “living” drugs with novel attributes to increase their therapeutic potency and safety.

PI_NAMEs: KREBS, SIMONE  (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TITLE: Interrogating the in vivo pharmacokinetics of armored CARs with radiohapten capture

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Sex differences in the incidence, age of onset, progression, and response to treatment in cancer are well documented. This project aims to understand how genetics contributes to observed cancer differences between men and women across a wide spectrum of cancers, with the goal of generating knowledge that can have a clinical impact. The project will: 1) Characterize sex differences at the molecular level in tumors derived from male and female patients, 2) Characterize sex differences in the contribution of inherited genetics to cancer risk, and 3) Discover mechanisms contributing to sex differences in response to cancer therapy.

PI_NAMEs: HUANG, RONG STEPHANIE ;STRANGER, BARBARA E (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TITLE: Genetic mechanisms underlying sexual dimorphism in cancer and response to therapy

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Anorexia nervosa is a deadly psychiatric illness defined by low body weight and associated with changes to many physiological systems in the body. This project will compare immune function and gut microbiome composition in a sample of female outpatients with anorexia nervosa and healthy comparison participants, and establish whether any differences are related to eating disorder symptoms. This basic knowledge will provide the required foundation to evaluate and interpret immune and gastrointestinal physiology in this clinical cohort, a required first step towards development of innovative, personalized treatments targeting these systems in anorexia nervosa.

PI_NAMEs: BRODRICK, BROOKS BARRETT (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TITLE: Immune Dysregulation in Eating Disorders (ID-ED)

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative In this proposal, we aim to use synthetic biology approaches to engineer synthetic gene networks to create engineered platelets for immunomodulation. The genetic tools build in this proposed work will have a broad yet significant impact on inflammatory disease treatments.

PI_NAMEs: DEANS, TARA LYNN (contact)

PROGRAM_OFFICER_NAME: RUSSELL, LUISA MARIE

PROJECT_TITLE: Synthetic circuits for therapeutic platelet production and immunomodulation

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: NARRATIVE In the last few decades clinical radiation therapy (RT) technology has developed dramatically, with intensity modulated RT (IMRT) representing one of the most significant advances, however, these advancements have not translated to preclinical small animal RT, which largely resembles the state of clinical RT in the 1970s in terms of its use of simple circular/rectangular beam geometries, uniform beam intensities, and lack of high quality 3D target dose conformality. Consequently, small animal RT studies do not allow for accurate 3D dose targeting or simulate the radiobiological, radioimmunological, hypoxic and toxicity environment of modern human RT. The goal of this proposed project is to create a novel 3D printed compensator IMRT (3DPC-IMRT) system that is low cost, easy to implement, and can allow high mouse throughput.

PI_NAMEs: WIERSMA, RODNEY  (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TITLE: Development of a 3D printed small animal intensity modulated radiation system

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Animals host complex communities of microbes that are part of the proper functioning of our bodies, and control of the microbiome by the immune system is critical for host health. This project will study how beneficial microbes and animal immune systems coevolve. By seeking this basic understanding of the evolutionary dynamics governing the microbiome, this research is relevant to the NIH’s mission to develop fundamental knowledge of living systems.

PI_NAMEs: PARKER, BENJAMIN JAMES (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TITLE: Understanding host-microbiome coevolution and genetic variation in immunity using an insect model system

STUDY_SECTION: MRAF

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


ORG_DEPT: PHYSICS

PHR: Project Narrative The computational model for bacterial growth and antibiotic response will identify the feedback pathways for antibiotic resistance. This will have direct influence on the design strategies for antibacterial therapies and protocols. Our study on cell state transitions in response to anoxia and metabolic arrest will identify the molecular mechanisms for inducing states of dormancy, limits to reversibility of dormant states and their preservation for cellular transplants.

PI_NAMEs: BANERJEE, SHILADITYA  (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TITLE: Biophysical models and mechanisms for cellular adaptation to environmental stress

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Breast cancer is the second leading cause of cancer death among women in the United States, with triple negative breast cancer (TNBC) being the most aggressive and deadly form, and the only breast cancer subtype where immunotherapy is approved. Psychosocial stress, experienced by a large majority of breast cancer patients, remains an understudied and underappreciated contributor to the development of aggressive disease and resistance to treatments, including immunotherapy. The proposed work will provide insights into a novel mechanism of psychosocial stress-induced immunosuppression and uncover promising approaches that could be translated for therapeutic benefit for patients with TNBC.

PI_NAMEs: GANDHI, SHIPRA  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TITLE: Stress-induced immunosuppression via downregulation of interferon in triple negative breast cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: Narrative Ultra-high dose rate radiation therapy has the potential to reduce the radiation damage seen in normal tissues, but most studies have been done with mice with the delivered plan drastically different from that in clinical treatments. The main goals of this study are to develop treatment planning system for the Mobetron® FLASHIQ for clinical and advanced FLASH-RT planning and evaluation, with deliveries validated via UHDR dosimetry for realistic cases. This study will advance the state-of-the-art in FLASH-RT by bridging the extensive gap between the basic science of FLASH and the clinical needs of FLASH for translation to human trials.

PI_NAMEs: ZHANG, RONGXIAO  (contact)

PROJECT_TITLE: Treatment Planning System for Electron FLASH radiation therapy


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: Project Narrative Esophageal cancer disproportionately affects US veterans and is associated with considerable morbidity and mortality. If repurposing the antifungal drug itraconazole to treat esophageal cancer successfully improves pathologic complete response rates in patients with surgically resectable disease, this should increase overall survival rates. Identifying which patients will respond to chemoradiation and itraconazole by developing novel biomarkers would maximize the impact of this intervention.

PI_NAMEs: WANG, DAVID H (contact)

PROJECT_TITLE: A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: CHARLESTON

ORG_NAME: WEST VIRGINIA STATE HEALTH DEPARTMENT

ORG_STATE: WV

PI_NAMEs: STOVER, MONICA J (contact)

PROJECT_TITLE: DP20-001 Pregnancy Risk Assessment Monitoring System (PRAMS)