ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: MELBOURNE

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: UNIVERSITY OF MELBOURNE

PHR: PROJECT NARRATIVE The overall aim of the proposed program of research is to better characterize and improve rediction of outcomes in the clinical high risk (CHR) for psychosis clinical population. This will lead to substantial benefits for clinical care (using dynamic risk calculators to estimate risk of a range of outcomes for individual patients, informing treatment strategy), healthcare services (informing decision-making regarding allocation of resources), and for research in this field (stratification of samples for treatment trials, directing the engagement of treatment targets, and refining aetiological models). The broad aim will be achieved by leveraging a recently established network of early psychosis service systems across Australia, including EPPIC and PACE at Orygen, to recruit, comprehensively assess and follow a large sample of CHR patients, with international partners recruiting an independent sample for validation purposes and to test generalizability of findings across healthcare settings.

PI_NAMEs: NELSON, CHRISTOPHER BARNABY (contact)

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Australia;Biological;Biological Markers;biopsychosocial;Calibration;Caring;Cessation of life;Clinic;Clinical;clinical care;Clinical Data;clinical high risk for psychosis;clinical infrastructure;clinical practice;Clinical Research;Clinical Services;clinical translation;Clinical Trials;cohort;Collaborations;Collection;comparison group;computerized data processing;Country;Data;Data Collection;Data Set;Decision Making;Denmark;digital;digital technology;disability;Disease;Disease Progression;Distress;Early Intervention;early psychosis;Early treatment;Economic Burden;Ensure;follow-up;functional outcomes;Funding;Future;Genetic;Germany;Goals;Health;health care service;health care settings;help-seeking behavior;Heterogeneity;high risk;high risk population;Hong Kong;Impairment;improved;Individual;individual patient;Infrastructure;International;international center;Intervention;Korea;Measures;Mental Health Services;Methodology;Modeling;Monitor;multimodal data;multimodal modeling;multimodality;National Institute of Mental Health;Netherlands;Neurobiology;Neurocognition;Neurocognitive;neuroimaging;neurophysiology;novel strategies;Outcome;outcome prediction;patient stratification;Patients;Performance;personalized medicine;Persons;polygenic risk score;Population;predictive modeling;Predictive Value;premature;Primary Care;Procedures;programs;Psychoses;Psychotic Disorders;Recovery;recruit;Registries;Research;Research Infrastructure;Resource Allocation;Risk;Risk Estimate;risk prediction;Sampling;Schizophrenia;schizophrenia risk;Service setting;Services;Singapore;Site;Specialist;Speech;Speed;Standardization;Stratification;success;Switzerland;symptomatology;Symptoms;System;Targeted Research;Testing;theories;therapy development;Time;tool;treatment effect;treatment response;treatment strategy;treatment trial;Trust;United Kingdom;usability;Validation;Work;Youth

PROJECT_TITLE: Trajectories and Predictors in the Clinical High Risk for Psychosis Population: Prediction Scientific Global Consortium (PRESCIENT)


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Lung;Pediatric;Pneumonia and Influenza;Precision Medicine;Prevention;Vaccine Related

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: RELEVANCE Influenza virus is a persistent global menace causing high morbidity and mortality each year with the constant threat pandemic spread. This project will lead to an improved understanding of how innate and adaptive immunity to influenza virus influences severe infection and its outcomes in young individuals, leading directly to new preventive and therapeutic approaches that will be relevant for people of all ages.

PI_NAMEs: RANDOLPH, ADRIENNE G (contact);THOMAS, PAUL G.

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 5 year old;Accounting;Acute;acute hypoxemic respiratory failure;adaptive immunity;Adult;Age;anti-influenza;Antibodies;antiviral immunity;Asthma;biobank;Biological;Biological Markers;biomarker identification;CD8-Positive T-Lymphocytes;Cessation of life;Child;Childhood;Chronic;Chronic Disease;Clinical;clinical phenotype;Clinical Trials;cohort;Containment;Critical Illness;Custom;cytokine;Data Set;design;Development;Disease;Disease Outcome;Disease susceptibility;DNA;druggable target;Elderly;endophenotype;Enrollment;Exclusion;Exhibits;exome sequencing;Functional disorder;Funding;Future;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;genome wide association study;healing;Health;Heart Diseases;Hemagglutination;Heterozygote;high risk;Hospitalization;Hospitals;Immune;Immune response;Immune System Diseases;Immunity;Immunobiology;Immunologic Markers;immunoregulation;Immunosuppression;Impairment;improved;Individual;Infection;Inflammation;Inflammatory;Influenza;Influenza A virus;influenza infection;Influenza vaccination;influenza virus strain;influenza virus vaccine;influenzavirus;inhibiting antibody;Integral Membrane Protein;Integration Host Factors;Intensive Care;Intensive Care Units;Interferons;Laboratories;Life;Lower Respiratory Tract Infection;Lung;Measures;Minor;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Allergy and Infectious Disease;Natural Immunity;next generation sequencing;novel;Nucleic Acids;Organ;Organ failure;Outcome;Outpatients;pandemic disease;pandemic influenza;pandemic potential;Parents;Pathogenicity;Pathway interactions;Patients;Pediatric Intensive Care Units;personalized care;Persons;Phenotype;predictive marker;Predisposition;Prevention;Preventive;preventive intervention;proband;prognostic;Prognostic Marker;rare variant;Recovery;Recurrence;repaired;Research Personnel;Resolution;Respiration Disorders;Risk;Risk Factors;risk prediction;risk stratification;Role;Sampling;School-Age Population;seasonal influenza;Severities;Severity of illness;Site;Stratification;Survivors;Symptoms;T cell response;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;TLR4 gene;vaccine failure;Validation;Variant;Viral;Virus;Virus Diseases;Virus Shedding;ward;Whole Blood;young adult

PROJECT_TITLE: Immunobiology of Influenza Virus-related Critical Illness in Young Hosts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: The proposed research is relevant to the public health because by identifying mechanisms through which family and work changes at a societal level contribute to cognitive and ADRD disparities. Our results will periods over the lifetime that may be sensitive to intervention.

PI_NAMEs: STERN, YAAKOV  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Address;Adult;Affect;Age;age related changes;aged;Alzheimer's disease related dementia;Alzheimer's disease risk;Behavioral;biobank;Biocompatible Materials;Birth;Brain;Buffers;Cessation of life;Characteristics;Child;child bearing;Clinical;Code;Cognition;Cognitive;Cognitive aging;cognitive development;cognitive testing;cohort;Complex;Consent;Country;Data;data registry;Data Set;Dementia;dementia risk;Diagnosis;Disease;Disparity;Economic Factors;Economics;Education;effective therapy;emerging adult;Employment;Environment;Event;Family;family structure;Fertility;follow-up;Frequencies;Genetic Predisposition to Disease;Genetic Risk;Health;Health behavior;health economics;Heterogeneity;Hormonal;Hour;Impaired cognition;improved;Incidence;Individual;Intervention;Investigation;Joints;Leisures;Length;Life;Life Cycle Stages;Link;longitudinal analysis;Marital Status;Marriage;Mediating;Medical;men;Modernization;Natural experiment;Norway;Occupations;older adult;Outcome;Participant;Pathway interactions;Pattern;Plants;polygenic risk score;Population;Population Study;Prevalence;Prevention;prospective;Prospective Studies;Public Health;Recording of previous events;Registries;Research;Resources;Retirement;Risk;Risk Factors;Sampling;sex;skills;Sleep;social;social disparities;socioeconomics;Sorting;spelling;Stress;Surveys;Unemployment;Variant;Woman;Work

PROJECT_TITLE: Changing lives, changing brains: How modern family and work life influences ADRD risks

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Osteoarthritis;Physical Injury - Accidents and Adverse Effects;Transplantation

ORG_CITY: CLEVELAND

ORG_DEPT: SURGERY

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: NARRATIVE The current standard of care for ACL injuries (400,000 each year) is ACL reconstruction, which is good at stabilizing the knee but requires compromising other uninjured structures around the knee to obtain an autograft that is subsequently used to replace the ACL. Further the early posttraumatic OA is not mitigated despite ACL reconstruction. A new technique, Bridge-Enhanced ACL Repair (the BEAR technique), where the ligament is stimulated to heal using a tissue engineered scaffold, has shown promising results in preclinical testing with lower rates of osteoarthritis and in initial safety cohort and small clinical trial. We now propose to conduct a 200 patient, multicenter, randomized controlled clinical trial of this novel technique against our current gold standard autograft ACL reconstruction.

PI_NAMEs: SPINDLER, KURT PAUL (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Affect;Age Years;Animal Model;Anterior;Anterior Cruciate Ligament;anterior cruciate ligament healing;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;anterior cruciate ligament rupture;Area;arm;Autologous;Autologous Transplantation;Biological;Biological Response Modifier Therapy;Blinded;Blood;clinical outcome measures;clinical practice;clinical translation;Clinical Trials;co-clinical trial;cohort;Cohort Studies;Collaborations;Complex;Data;Degenerative polyarthritis;delivery vehicle;Devices;Documentation;efficacy outcomes;effusion;Enrollment;Environment;experience;Failure;FDA approved;first-in-human;Foundations;Funding;Harvest;healing;health related quality of life;Human;improved;Inferior;Injury;International;Joints;Knee;Knee Osteoarthritis;Ligaments;Measures;mechanical properties;Meniscus structure of joint;Meteor;Modeling;novel;Operative Surgical Procedures;Orthopedics;Outcome;Outcome Measure;patellar tendon;Pathology;Patient Outcomes Assessments;Patients;Physical Examination;Planet Mars;pre-clinical;Pre-Clinical Model;preclinical study;Preclinical Testing;premature;Prevention;primary endpoint;primary outcome;Procedures;Protocols documentation;Randomized;Randomized Controlled Clinical Trials;randomized, clinical trials;Randomized, Controlled Trials;Regenerative Medicine;repaired;Research Personnel;Rotator Cuff;Running;Safety;scaffold;Scaffolding Protein;Site;standard of care;Statistical Data Interpretation;Structure;success;Synovial Fluid;Techniques;Technology;Tendon structure;Testing;Tissue Engineering;Tissue Harvesting;Tissues;Traumatic Arthropathy;trial comparing;United States National Institutes of Health;Work;wound healing

PROJECT_TITLE: BEAR-MOON: A Two Arm Noninferiority Blinded Randomized Clinical Trial Comparing ACL Repair with BEAR Device vs. Standard of Care Autograft Patellar Tendon ACL Reconstruction


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Contraception/Reproduction;Genetics;Infectious Diseases;Microbiome;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE There are currently no interventions that predictably and durably shift the human vaginal microbiome toward the optimal Lactobacillus dominant microbial community associated with lower risk for infection, cervical dysplasia and adverse pregnancy outcomes. Antibiotics and probiotics, or a combination of the two have been tried, with limited success. We propose a randomized trial of vaginal microbiota transplant in women with recurrent bacterial vaginosis, as an in vivo experimental model to better define the factors that drive composition of the vaginal microbiota. We will perform deep sequencing analysis and comprehensive characterization of host, donor and transplanted material, which will allow us to assess causal relationships between microbial features and colonization, and identify novel strategies for a durable, predictable intervention for vaginal health.

PI_NAMEs: MITCHELL, CAROLINE M (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: 16S ribosomal RNA sequencing;Adverse event;adverse event monitoring;adverse pregnancy outcome;Anaerobic Bacteria;Animal Model;Antibiotic Therapy;Antibiotics;Area;arm;Bacterial Vaginosis;Biological Response Modifier Therapy;candidate selection;Cervical dysplasia;cervicovaginal;Characteristics;Chemicals;Clinical;Clostridium difficile;Collection;Communities;comparative genomics;Complex;Data;Databases;deep sequencing;design;Development;Donor person;Dose;dysbiosis;efficacy evaluation;Engraftment;Enrollment;Experimental Models;fecal transplantation;follow-up;Formulation;Future;Genes;Genetic;genital microbiome;Genitalia;genome sequencing;Goals;gut microbiota;Health;HIV;Human;Human Papillomavirus;immune activation;improved;In Vitro;in vivo;Individual;Infection;infection risk;Inflammation;inflammatory marker;insight;interest;Intervention;Intervention Studies;Kinetics;Lactobacillus;Link;Metabolic;metabolic profile;metabolomics;metagenomic sequencing;Metronidazole;microbial;microbial colonization;microbial community;microbiome;microbiota;microbiota transplantation;Mucosal Immune Responses;Mucositis;multi-component intervention;novel;novel strategies;novel therapeutic intervention;Oral;Organism;Outcome;Placebos;post intervention;prebiotics;Premature Birth;Premenopause;Prevalence;Prevention;primary outcome;probiotic therapy;Probiotics;Public Health;Randomized;randomized trial;randomized, clinical trials;Recording of previous events;recruit;Recurrence;Relapse;Reproductive Health;restoration;Risk;Safety;safety testing;Saline;scale up;secondary outcome;Shotguns;Spontaneous abortion;success;Testing;therapy design;Transplant Recipients;Transplantation;Treatment Efficacy;Vagina;vaginal fluid;vaginal lactobacilli;vaginal microbiome;vaginal microbiota;whole genome;Woman;Women's Health;women's treatment

PROJECT_TITLE: Vaginal microbiota transplant to promote Lactobacillus-dominant cervicovaginal communities

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: Youth in all types of justice settings are at substantial risk for suicidal behavior (SB) and correlated poor outcomes, yet protocols for SB identification and service delivery, while common for those in secure care, are rare for those in community settings (e.g., probation). e-Connect is one of the few evidence-based, digital clinical-decision support systems that assists probation officers in identification of SB and associated behavioral health need, and in successful referral of youth across systems to improve youth uptake of behavioral health treatment. In this proposal, we address a critical public and juvenile justice health need – identifying and preventing SB in youth on probation -- as we scale-up e-Connect and identify implementation strategies that will ensure the successful transfer of knowledge, skill and expertise in delivering e-Connect to support the more widespread, sustained and rigorous adoption of e-Connect in new contexts.

PI_NAMEs: AALSMA, MATTHEW ;ELKINGTON, KATHERINE S (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: Address;Adolescent;Adoption;African American;Behavior;behavioral health;Caring;Cause of Death;Classification;Clinical;Clinical Decision Support Systems;Clinical effectiveness;Collaborations;Communities;community setting;contextual factors;cost effectiveness;County;Data;Data Set;design;digital;disparity reduction;effectiveness/implementation hybrid;effectiveness/implementation trial;efficacy testing;efficacy trial;Ensure;Equity;ethnic disparity;Ethnic Origin;Evaluation;evidence base;Evidence based intervention;Exploration, Preparation, Implementation, and Sustainment;firearm access;Gender;General Population;Geography;Goals;Health;health disparity;health service use;Health Services;Health Services Needs;Health system;Home;hybrid type 2 design;implementation framework;implementation science;implementation strategy;improved;Indiana;Intervention;Justice;juvenile justice system;Knowledge;Leadership;Mediating;Minority;Modeling;Monitor;Moods;multidisciplinary;National Institute of Mental Health;New York;Outcome;Performance;Positioning Attribute;Prevalence;primary outcome;probation;probationer;programs;Protocols documentation;Provider;Public Health;Race;racial disparity;Randomized;Research;Risk;Risk Behaviors;scale up;screening;Secure;service delivery;Service provision;Services;skills;Substance Use Disorder;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Supervision;System;Testing;tool;trauma exposure;treatment comparison;uptake;web app;Work;Youth

PROJECT_TITLE: Scaling up eConnect in Juvenile Probation Settings: a hybrid implementation-effectiveness trial of a digital suicide risk/behavior identification and linkage-to-treatment system


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE The decision process regarding treatment with chemotherapy in older women with early-stage breast cancer can be difficult. Patients and physicians as must not only consider the benefits and side-effects of treatments, but also the other medical conditions that a patient may be dealing with and a patient's own personal values and preferences. The goal of our project is the development of a decision-aid to be used by patients and physicians to help navigate this important decision process.

PI_NAMEs: KARUTURI, MEGHAN SRI (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: acceptability and feasibility;Adult women;Adverse effects;Advocate;Age;Benefits and Risks;Breast Cancer Risk Factor;Breast Cancer Treatment;Cancer Center;Cancer Patient;chemotherapy;Clinical;clinical risk;Clinical Trials Design;Collaborations;Communication;comorbidity;Complex;Conflict (Psychology);Consensus;County;County Hospitals;Data;Decision Aid;Decision Making;design;Development;Disease;Early treatment;Education;efficacy evaluation;empowerment;Evaluation;expectation;experience;Exposure to;Feedback;Feeling;field study;Goals;Guidelines;health communication;Health Personnel;Hospitals;human old age (65+);improved;International;Knowledge;Life Expectancy;Literature;Malignant Breast Neoplasm;Measures;Medical;Methodology;Methods;Nurses;older adult;older patient;Older Population;older women;Oncologist;Outcome;Patient Care;patient oriented;Patient Outcomes Assessments;patient population;Patient Preferences;Patients;Perception;Physicians;Pilot Projects;preference;Probability;Process;Prognosis;Provider;provider communication;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Research;Research Personnel;Risk;Role;safety net;Sampling;Science;shared decision making;skills;support tools;tool;Toxicity due to chemotherapy;Training Activity;Treatment outcome;treatment risk;Treatment Side Effects;Uncertainty;University of Texas M D Anderson Cancer Center;usual care arm;Visit;Woman;Work

PROJECT_TITLE: Developing a Decision Tool for Chemotherapy in Older Women with Early Stage Breast Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: SYRACUSE

ORG_NAME: SYRACUSE VA  MEDICAL CENTER

PHR: Whole Health STEPS (Structured Tiered Engagement with Peer Support) is designed to improve functional outcomes for primary care Veterans with mental health concerns who are not actively engaged in mental health services. Whole Health STEPS uses a Peer Support Specialist, or Peer, to provide support for Veterans to make progress on wellness goals using the Whole Health model. The level of support provided will be determined based on Veterans’ progress and will be stepped-up based on pre-defined decision points through four levels of care until Veterans receive the level of support they need. Whole Health STEPS will improve existing VA healthcare services through offering a non-mental health referral option for Veterans with mental health concerns who are not engaged in services, providing a structured package of existing Whole Health services that enrolls Veterans in the appropriate level of care, and providing a structured service for peers in primary care settings to offer to primary care Veterans.

PI_NAMEs: JOHNSON, EMILY  (contact)

PROJECT_TERMS: acceptability and feasibility;associated symptom;barrier to care;Belief;career;Caring;Categories;Characteristics;Clinical;Clinical Trials Design;Confidence Intervals;Data;Data Analyses;Data Collection;design;Development;Diagnostic;Doctor of Philosophy;Drops;Elements;Enrollment;Equipment and supply inventories;Evidence based practice;feasibility research;feasibility testing;Feedback;flexibility;Functional impairment;functional improvement;functional outcomes;future implementation;Goals;Health;health care service;health goals;health plan;Health Services;Healthcare;Hour;implementation evaluation;improved;Individual;Intervention;Interview;Manuals;Mental disorders;Mental Health;Mental Health Services;Methods;Military Personnel;Mission;Modeling;novel strategies;Occupational;Outcome;Outcome Measure;Participant;patient engagement;patient oriented;Patient-Focused Outcomes;peer;peer support;Population;Primary Care;primary care setting;primary outcome;Process;Process Assessment;Provider;Psychologist;psychosocial;Psychotherapy;Qualitative Evaluations;Qualitative Methods;Randomized;randomized, clinical trials;Recording of previous events;Recovery;Research;retention rate;Role;satisfaction;Self Assessment;Self Direction;Self Management;Services;skills;social;Specialist;statistics;Structure;Symptoms;Techniques;Telephone;telephone coaching;Testing;Time;tool;Training;Training Support;United States Department of Veterans Affairs;uptake;Veterans;Veterans Health Administration;Vision;Waiting Lists;Well in self;whole health;willingness

PROJECT_TITLE: Initial Testing of Whole Health STEPS (Structured Tiered Engagement with Peer Support)

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Deep brain stimulation of the subthalamic nucleus (STN DBS) can provide motor benefit yet occasional mood and cognitive side effects in Parkinson disease (PD). It is thought that downstream network level effects are a critical mechanism of STN DBS’s influence on motor and non-motor behavior, however our ability to test this hypothesis has been limited due to safety concerns about magnetic resonance imaging (MRI) in people with DBS. We have developed a safe and novel high-density diffuse optical tomography (HD-DOT) system for measuring brain networks in cortex. With HD-DOT, we will test hypotheses about networks that are responsive to important characteristics of STN DBS (e.g. location) and their relationship to motor and non-motor function. This information could help with guiding the selection of DBS parameters for clinical treatment, identify cortical areas involved in the benefits or side effects of DBS, and reveal fundamental properties of cortical network plasticity.

PI_NAMEs: CULVER, JOSEPH P;HERSHEY, TAMARA G (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: 3-Dimensional;Affect;Anatomy;Area;Auditory;Behavior;Behavioral;Brain;cerebral hemodynamics;Characteristics;Clinical;Clinical Treatment;Cognition;Cognitive;cognitive change;Collection;comparison control;Complex;Corpus striatum structure;Data;Deep Brain Stimulation;density;diffuse optical tomography;Dorsal;Double-Blind Method;Enrollment;Evaluation;Experimental Designs;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Future;Head;Human;Image;imaging detector;imaging modality;Impaired cognition;Implant;implantation;improved;Individual;Literature;Location;Magnetic Resonance Imaging;Maps;Measurable;Measurement;Measures;Mediating;Metals;Methods;Modeling;Moods;Morphologic artifacts;Motor;motor disorder;Movement;Nature;neuromechanism;neuropathology;neuroregulation;novel;Operative Surgical Procedures;Parkinson Disease;Patients;Persons;Physiology;Play;Positron-Emission Tomography;Property;Radiation exposure;Resolution;response;Rest;Role;safe patient;Safety;Scalp structure;Scanning;Sensory;side effect;Signal Transduction;Source;Specificity;STN stimulation;Structure of subthalamic nucleus;support network;System;temporal measurement;Testing;Thalamic structure;Time;tool;Validation;Visual;Work

PROJECT_TITLE: Cortical Network Modulation by Subthalamic Nucleus Deep Brain Stimulation

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Project Narrative Women living in sub-Saharan Africa with human immunodeficiency virus (HIV) infection are at the greatest risk of getting and dying from cervical cancer. The proposed study will compare two methods of treating cervical abnormalities for the prevention of cervical cancer in Mozambican women living with HIV. Goals of the study are to identify the best treatment and reduce treatment failures in these women.

PI_NAMEs: SCHMELER, KATHLEEN  (contact);VIEGAS, EDNA

PROGRAM_OFFICER_NAME: LIDDELL HUPPI, REBECCA

PROJECT_TERMS: Ablation;Acetic Acids;Acquired Immunodeficiency Syndrome;Address;Adherence;Adolescent;Adoption;Adult women;Adverse event;Affect;Africa South of the Sahara;Aftercare;Age;Algorithms;alternative treatment;automated visual evaluation;Biopsy;Cancer Burden;Cancer Etiology;cancer risk;Cancerous;Carbon Dioxide;Caring;Cellular Phone;Cervical;cervical cancer prevention;Cervical Cancer Screening;Cervical dysplasia;Cervical Intraepithelial Neoplasia;Cervix Uteri;Cessation of life;cohort;Cold Therapy;Community Health Aides;comparative effectiveness;comparative safety;compare effectiveness;Consent;Data;deep learning;deep learning algorithm;Devices;Diagnosis;digital;digital imaging;DNA;Early Diagnosis;Early treatment;effective therapy;Effectiveness;effectiveness evaluation;Electricity;Electrocoagulation;Eligibility Determination;Emergency Situation;Ensure;Evaluation;Excision;experience;follow-up;Freezing;Future;Gases;Generations;Genotype;global health;Goals;Guidelines;Health Priorities;health training;High Risk Woman;HIV;HIV diagnosis;HIV Seronegativity;Home;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papillomavirus;Knowledge;Lesion;light weight;Local anesthesia;Location;loop electrosurgical excision procedure;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medical;Meta-Analysis;Method Acceptability;Methods;Mozambique;necrotic tissue;Nitric Oxide;Pain;Pain Measurement;point of care;Population;portability;Positioning Attribute;premalignant;Prevalence;prevent;Prevention strategy;programs;Randomized;randomized, clinical trials;Rapid screening;rechargeable battery;Recommendation;recruit;Recurrence;Resources;Risk;Risk Factors;Risk Reduction;screening;secondary analysis;Serious Adverse Event;Severities;Speculums;standard care;standard of care;Technical Expertise;Technology;Testing;Time;Tissues;Topical application;treatment comparison;Treatment Effectiveness;Treatment Failure;Triage;Vaccination;Viral;Viral Load result;virtual;Virus Diseases;Visit;Visual;Woman;women's morbidity;Women's mortality;Work;World Health Organization

PROJECT_TITLE: A Randomized Clinical Trial to Assess the Effectiveness of Ablative Treatments for Cervical Cancer Risk Reduction in HIV+ Women living in Mozambique

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Monoclonal antibodies have revolutionized the treatment of many malignancies, autoimmune disorders, and infectious disease, but have poor patient adherence due to required repeat injections. Plasma cells engineered to express therapeutic monoclonal antibodies may provide an alternative therapy that may only need to be dosed once in order to provide life-long therapeutic effects. This proposal seeks to generate anti-EBV monoclonal antibody secreting primary plasma cells and validate their ability to provide protection from EBV infection in an autologous humanized mouse model.

PI_NAMEs: HILL, TYLER F (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Ablation;Address;Affinity;Alternative Therapies;Animal Model;Antibodies;Autoimmune Diseases;Autoimmunity;Autologous;B cell differentiation;B-Lymphocytes;career;Cell secretion;Cell Separation;Cell Survival;Cell Therapy;Cells;Cellular biology;cellular engineering;chimeric antigen receptor T cells;Clinical;clinical application;Communicable Diseases;Complement;cost;CRISPR/Cas technology;Cytoprotection;Data;Dengue;design;Disease;DNA Repair;Dose;effective therapy;Engineered Gene;Engineering;Engraftment;Ensure;Epstein-Barr Virus Infections;Future;gene-editing approach;Genes;Hematopoietic;Hematopoietic stem cells;HIV;Human;Human Cell Line;Human Herpesvirus 4;humanized mouse;Immunity;Immunocompromised Host;immunodeficiency;Immunoglobulin G;Immunoglobulin-Secreting Cells;improved;In Vitro;Infectious Agent;Infectious Mononucleosis;Influenza;Infusion procedures;Injections;interest;Intravenous;Intravenous infusion procedures;Light;Lymphoproliferative Disorders;Malignant Neoplasms;Medical Education;Mentorship;Methods;Modeling;Monoclonal Antibodies;Monoclonal Antibody Therapy;mouse model;Mus;Myeloid Cells;neutralizing antibody;neutralizing monoclonal antibodies;novel therapeutics;Patient Compliance;Peripheral Blood Mononuclear Cell;Physicians;Plasma;Plasma Cells;preclinical study;Predisposition;Protein Deficiency;Publishing;Research;Safety;Scientist;Stromal Cells;Testing;Therapeutic;Therapeutic Effect;Therapeutic Monoclonal Antibodies;Time;Training;translational immunology;Transplant Recipients;Tropical Disease;Universities;vaccine access;vector;Virus;Washington

PROJECT_TITLE: Developing Monoclonal Antibody Secreting Human Plasma Cells to Provide Long-Lasting EBV Immunity in Humanized Mice


ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative  Intracranial atherosclerotic disease (ICAD), is one of the largest causes of stroke in the world. After surviving the initial ICAD stroke, roughly 1 of 8 will have a second devastating stroke within the next year. There is currently no way to determine who will fall victim to the second ICAD stroke. The use of Magnetic Resonance Imaging (MRI) is widespread in the evaluation of patients ICAD. Typically, MRI is used to locate the pathological narrowing (i.e. stenosis) of a blood vessel in the brain (intracranial stenosis/plaque). We will develop new MRI scans to measures a patients’ ability to re-route around a stenosis, gradual loss of compensatory reserve and the likelihood that the stenosis “throws off” a blood clot. It is these risk factors of an that could change the management to prevent an impending stroke. Our long term goal is to develop advance MRI scans that create images to better identify patients destine for a stoke, so that eventually the disease can be aggressively treated to PREVENT a secondary stroke.

PI_NAMEs: ANSARI, SAMEER A;CARROLL, TIMOTHY J (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Acetazolamide;Age Years;Algorithms;angiogenesis;Angioplasty;Arterial Fatty Streak;Arteries;Aspirin;Atherosclerosis;Biological Markers;Blood;Blood coagulation;Blood Platelets;Blood Vessels;Brain;Breathing;Carbon Dioxide;Cardiac;Cephalic;cerebrovascular;Cerebrovascular system;Chronic;Chronic Disease;Clinical;clinical translation;Complex;contrast enhanced;Contrast Media;Death Rate;Disease;Distal;Ensure;Evaluation;Event;Exhibits;falls;ferumoxytol;Geometry;Goals;Head;hemodynamics;Hemorrhage;high risk;high risk population;Hospitals;Human;Hypertension;hypoperfusion;Image;imaging biomarker;improved;Inferior;Infiltration;Inflammation;Inflammatory;innovation;Intracranial Arterial Stenosis;intracranial artery;Intracranial Atherosclerotic Disease;Iron;Ischemic Stroke;Legal patent;Lesion;Macrophage;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Managed Care;Mathematics;Measures;Medical;Methodology;Molecular;MRI Scans;Multicenter Trials;multidisciplinary;Natural History;neurovascular;novel;Oxygen;Pathologic;Pathology;Pathway interactions;patient population;Patient risk;Patients;Perfusion;perfusion imaging;Permeability;Pharmaceutical Preparations;physiologic stressor;Plavix;Population;pressure;Prevalence;prevent;Prevention;Preventive treatment;Probability;Procedures;Protocols documentation;Recurrence;Reference Standards;Reporting;Research;Resolution;response;Rest;Risk;Risk Factors;Risk Management;risk stratification;Role;Route;Rupture;single photon emission computed tomography;Smoking;standard of care;Stenosis;Stents;Stress;Stroke;Stroke prevention;stroke risk;success;Systems Theory;Techniques;thromboembolic stroke;Thrombus;Time;tissue oxygenation;Tissues;uptake;vasa vasorum;vascular bed;Vascular blood supply;Vascular resistance;Vasodilation;Warfarin;Work

PROJECT_TITLE: Predicting Stroke Risk in Intracranial Atherosclerotic Disease with Novel High Resolution,Functional and Molecular MRI Techniques - Resubmission - 1

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Aging;Genetics;Infectious Diseases;Lung

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE The immune homeostatic state influences immune responses to infection, but is itself is a function of age, environmental stressors, and underlying genetics. Therefore, it is critical to understand the interplay between these factors and their overall impact on systemic and organ specific immunity at the steady state. This proposal studies the mechanism by which genetic variants in Methyl-CpG binding domain protein 1 regulates steady state antibody levels, and further proposes to extend the work on immune homeostasis to investigate the interaction between age and cytomegalovirus in modifying the immune architecture in the lungs and responses to respiratory infections.

PI_NAMEs: BROWN, BREA HAMPTON (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Age;age related changes;Aging;aging related;Alleles;Animals;Antibodies;Architecture;Autoimmunity;B cell differentiation;B-Lymphocyte Subsets;B-Lymphocytes;Bacterial Infections;Candidate Disease Gene;CD19 gene;Cells;Chromatin;Chromosome 18;Chronic;cohort;Cytomegalovirus;Cytomegalovirus Infections;Data;data integration;Effector Cell;Elderly;Environment;Environmental Exposure;Environmental Risk Factor;environmental stressor;Gene Expression;gene network;Genes;Genetic;genetic variant;Genetic Variation;Genome;Genotype;germ free condition;Goals;Haplotypes;Herpesviridae;Homeostasis;Hypersensitivity;IgG1;Immune;Immune response;Immune system;Immunity;Immunoglobulin D;Immunoglobulin M;Immunoglobulin-Secreting Cells;immunoregulation;immunosenescence;improved;In Vitro;in vivo;Infection;Inflammation;insight;inter-individual variation;interest;Lung;Malignant Neoplasms;Mature B-Lymphocyte;Mediating;Morbidity - disease rate;mortality;mouse model;neonatal human;old mice;Organ;Phenotype;Play;Postdoctoral Fellow;programs;Protein Binding Domain;protein function;protein protein interaction;Quantitative Trait Loci;Readiness;Regulation;Research;Research Personnel;Resistance;respiratory pathogen;Respiratory Tract Infections;response;Role;secondary infection;Secondary to;Serum;Site;Spleen;T-cell receptor repertoire;Tissues;Vaccination;Variant;Work

PROJECT_TITLE: Evaluating the role of cytomegalovirus and age on lung immune homeostaasis and response to respiratory infections


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Pediatric;Pediatric - AIDS;Rare Diseases;Tuberculosis

ORG_CITY: TYLER

ORG_NAME: UNIVERSITY OF TEXAS HLTH CTR AT TYLER

PHR: Mycobacterium tuberculosis (Mtb) infects one-third of the world’s population and causes almost 1.3 million deaths per year, including 100, 000 children. Approximately 90% of infected persons have latent tuberculosis infection (LTBI), have protective immunity and remain well, but 10% develop primary tuberculosis (TB) soon after infection or reactivation TB many years later. TB is the leading cause of death in HIV-infected persons and more than half a million coinfected people die annually. Children are more susceptible to TB infection, due to an immature immune system. HIV infection in children markedly increases susceptibility to TB. To develop adequate prophylaxis or therapy, it is important to understand immune responses to Mtb. Identification of HIV+ children with LTBI who are at greatly increased risk for development of TB would allow treating only high-risk children, facilitating completion of therapy for LTBI and preventing future development of TB. To identify these children, it is important to pinpoint the nature of the defective immune responses that permit development of active TB in HIV+LTBI+ pediatric patients. This proposal will identify a novel memory-like NK cell subpopulation mediated mechanisms that regulate immune responses and pinpoint the nature of the defective responses that permit development of active TB in HIV-LTBI+ and HIV+LTBI+ children. These studies will lay the groundwork for strategies to develop novel anti-tuberculosis vaccines that stimulate strong NK cell mediated immunity in HIV+ and HIV- children with LTBI, and reduce development of TB.

PI_NAMEs: VANKAYALAPATI, RAMAKRISHNA  (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: adaptive immune response;Adult;Age;Antitubercular Agents;Blood specimen;Cause of Death;CD8-Positive T-Lymphocytes;cell mediated immune response;Cells;Cellular Immunity;Cessation of life;chemokine;Child;cohort;cytokine;Defect;Development;Family;FOXP3 gene;Future;Genetic Polymorphism;Growth;Haplotypes;high risk;Highly Active Antiretroviral Therapy;HIV;HIV Infections;HIV/TB;Household;Human;IL2RA gene;Immune;Immune response;Immune system;Immunity;Immunoglobulins;India;Individual;individual response;Infection;Innate Immune Response;interleukin-21;interleukin-21 receptor;Investments;Killer Cells;Macrophage;Measures;Mediating;Memory;monocyte;Mus;Mycobacterium tuberculosis;Natural Killer Cells;Nature;novel;Patients;pediatric patients;Persons;Phenotype;Play;Population;Predisposition;prevent;Production;progression risk;Prophylactic treatment;Publishing;receptor;Reporting;Research;Research Personnel;Resistance;response;Response Latencies;Risk;Role;Sampling;Series;Site;T cell response;Time;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;Vaccines

PROJECT_TITLE: Innate immune response of LTBI+HIV+ children


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Liver Disease;Microbiome;Natural Products;Nutrition;Prevention;Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_DEPT: BIOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: The goals of this project are to investigate the mechanisms of probiotic Lactobacillus rhamnosus GG action on alcoholic liver disease. This study will have a major impact on the development of a probiotics-based new therapeutic strategy for the prevention and treatment of alcoholic liver disease. PHS 398/2590 (Rev. 05/01) Page 1 Continuation Format Page

PI_NAMEs: FENG, WENKE  (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Acute;Agonist;alcohol abuse therapy;alcohol exposure;Alcohol-Induced Disorders;Alcoholic Liver Diseases;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Bacteria;Bacterial Translocation;Bilophila wadsworthia;Cells;Chronic;Development;Digestive System Disorders;Disease;dysbiosis;Endocytosis;Environment;Epithelial Cells;Epithelium;exosome;Experimental Models;Ginger;Goals;Growth;gut colonization;gut inflammation;gut microbiota;Homeostasis;improved;interleukin-22;intestinal barrier;intestinal epithelium;Intestines;islet;Lactobacillus casei rhamnosus;Mediating;metabolomics;microbial;mouse model;Mus;nanoparticle;Natural regeneration;novel therapeutic intervention;Oxidative Stress Induction;pathogenic bacteria;Pathogenicity;Pathway interactions;Play;prebiotics;prevent;Prevention;Prevention strategy;probiotic therapy;Probiotics;Production;protective effect;Receptor Signaling;Regenerating islet derived protein 3-Gamma;Role;Signal Transduction;Testing;Therapeutic Effect;Tight Junctions;transcytosis;Tryptophan;Up-Regulation

PROJECT_TITLE: Mechanisms of Probiotics in Alcoholic Liver Disease

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative Despite maximal surgery, radiation and chemotherapy, glioblastoma (GBM) remains invariably recalcitrant, and necessitates development of new therapies. We have developed a novel FDA-IND approved agent (BB-19304, Sayour) utilizing RNA-lipid nanoparticles (RNA-LPs) to reprogram innate/adaptive immunity against GBM. In this proposal, we will explore the safety, maximum tolerated dose (MTD), and immunologic activity of RNA-LPs in a first-in-human clinical trial (NCT04573140) for patients with newly-diagnosed GBM.

PI_NAMEs: SAYOUR, ELIAS  (contact)

PROGRAM_OFFICER_NAME: SUN, HAIHAO

PROJECT_TITLE: A phase I study of RNA-lipid particle vaccines for newly-diagnosed glioblastoma, IND19304 08/21/2020


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Allergy is a health problem of epidemic proportions for which there are limited treatment options. Our recent study revealed that the long non-coding RNA Morrbid regulates the function of CD4+ T cells and their responses to allergens. Understanding how Morrbid functions at the molecular level in CD4+ T cells is expected to identify pathways that could be targeted to improve allergy treatment.

PI_NAMEs: WILLIAMS, ADAM  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Ablation;Affinity;airborne allergen;Alleles;Allergens;Allergic;Allergic Disease;allergic response;Alternaria;Anaphylaxis;Anti-sense RNA;Antibody Formation;Antibody Response;Apoptotic;Area;Automobile Driving;B-Lymphocytes;BCL2L11 gene;Binding;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Physiology;cell type;Cells;Chromatin;Chromatin Interaction Analysis by Paired-End Tag Sequencing;Chromatin Loop;Chromosome Mapping;Communities;Coupled;CRISPR/Cas technology;cytokine;Data;Dendritic Cells;DNA;Elements;eosinophil;Epidemic;Epigenetic Process;epigenetic silencing;epigenome editing;experimental study;Gene Expression;Gene Targeting;Generations;Genes;Genetic;genetic regulatory protein;Genetic Transcription;Genome Mappings;genome wide association study;genome-wide;Goals;Health;Helper-Inducer T-Lymphocyte;Human;Hypersensitivity;IgE;Immune response;Immunity;Immunization;improved;In Vitro;in vivo;Interleukin-13;Interleukin-4;Interleukin-5;Life;Lung;lung histology;Maps;Mass Spectrum Analysis;Methodology;Methods;Modeling;Molecular;Mus;novel;overexpression;Pathway interactions;Phenotype;PI3K/AKT;polarized cell;Production;promoter;Proteins;Regulation;Regulator Genes;Regulatory Element;Regulatory Pathway;Research;response;RNA;Role;Signal Transduction;single-cell RNA sequencing;T cell response;T-Lymphocyte;Testing;Th2 Cells;Therapeutic Intervention;therapeutic target;tool;Transcript;tRNA Precursor;Untranslated RNA;Work

PROJECT_TITLE: Long Non-Coding RNAs in Allergy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(57)]


ORG_CITY: DETROIT

ORG_NAME: HENRY FORD HEALTH SYSTEM

ORG_STATE: MI

PHR: The microbial community colonizing a newborn baby's gastrointestinal tract is very important for the ongoing development of that community, which has a strong impact on the optimal development of the baby's immune system, leading to better child and adult health and specifically the prevention of allergy and allergic asthma. This collection of projects will identify relationships between factors influencing a mother's gastrointestinal and vaginal microbes during pregnancy, and how these factors and the mother's microbes affect her newborn's gastrointestinal microbial community and immune system development from birth through the first years of life in both human and mouse studies. We believe that taken together these advances in understanding will lay the foundation for a strategy for the primary prevention of allergies and asthma.

PI_NAMEs: JOHNSON, CHRISTINE C  (contact);ZORATTI, EDWARD M

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: 10 year old;2 year old;Address;Adult;Affect;Age Months;Allergens;Allergic;Allergic Disease;Allergic inflammation;Asthma;Bacteria;Birth;Bone Marrow;Breast Feeding;Canis familiaris;Characteristics;Child;Childhood;Childhood Asthma;cohort;Collection;Communities;Community Developments;Consensus;Dendritic Cells;design;Development;Dietary Factors;Dust;Environment;Environmental Exposure;Environmental Risk Factor;Exhibits;Exposure to;Extrinsic asthma;Feces;feeding;Female;Food;Foundations;gastrointestinal;Gastrointestinal tract structure;gene function;Goals;gut microbes;gut microbiota;Health;high risk;Home;House Dust;Human;Human Milk;Hypersensitivity;IgE;Immune;Immune system;in utero;in vitro Assay;Incidence;individualized prevention;Infant;Infant Development;Inflammation;Inhalant dose form;Intervention;Joints;Lactobacillus;Life;lifestyle factors;Lymphocyte;Maternal Exposure;maternal microbiota;Metabolic;metabolic profile;metagenomic sequencing;Microbe;microbial;microbial community;microbial composition;microbiota;microbiota composition;microbiota metabolites;Mothers;mouse model;Mus;neonate;Newborn Infant;offspring;Oral Administration;oral supplementation;Organism;Partner in relationship;Pattern;pet animal;Phenotype;Population;Pregnancy;Pregnant Women;prenatal;Prevalence;prevent;Prevention;Preventive;Primary Prevention;protective effect;Pulmonary Inflammation;pup;Regulatory T-Lymphocyte;Research;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Risk;Risk Reduction;Serum;Shotguns;Skin;Source;Specimen;suckling;Systems Development;Time;United States;Vagina;Vaginal delivery procedure;vaginal microbiota;Virus;Work

PROJECT_TITLE: Microbiota and Allergic Asthma Precision Prevention (MAAP2)


NIH_SPENDING_CATS: Asthma;Breastfeeding, Lactation and Breast Milk;Complementary and Integrative Health;Dietary Supplements;Health Effects of Indoor Air Pollution;Infectious Diseases;Lung;Maternal Health;Microbiome;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Prevention;Women's Health Research

PI_NAMEs: LUKACS, NICHOLAS W (contact)

PROJECT_TERMS: 10 year old;Address;Affect;Allergens;Allergic;Allergic Disease;allergic response;Animal Model;Animals;Asthma;attenuation;Bacteria;Bone Marrow;Breast Feeding;Breeding;Canis familiaris;Cell Physiology;Cells;Child;Childhood;Circulation;Clinical Research;Data;Dendritic Cells;Development;Disease;Dust;effective intervention;Environment;epidemiology study;experimental study;Extrinsic asthma;Female;Fostering;gut microbiota;Health;high risk;Home;Homeostasis;House Dust;Human;Human Milk;Hypersensitivity;Immune;Immune response;in utero;individualized prevention;Infant;insight;Intestines;Knowledge;Lactobacillus;Life;Lipids;long-term sequelae;Lung immune response;maternal microbiome;maternal microbiota;Metabolic;metabolic profile;metabolome;microbial;microbiome;microbiota;Mothers;mouse model;Mus;Neonatal;neonatal infection;neonatal mice;neonate;offspring;Omega-3 Fatty Acids;oral supplementation;Partner in relationship;Pathogenicity;Pathologic;Pathology;pet animal;Phenotype;Population;Postpartum Period;preclinical study;Predisposition;Pregnancy;Pulmonary Inflammation;pup;Reaction;Resistance;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;response;Risk;Risk Reduction;Shapes;Stimulus;Supplementation;System;Testing;Weaning

PROJECT_TITLE: Project 4  Alteration of Mouse Maternal Gut Microbiota Alters Metabolic Profiles and Immune Phenotype in Offspring


PI_NAMEs: LYNCH, SUSAN VERONICA (contact)

PROJECT_TERMS: 10 year old;2 year old;4 year old;Address;Affect;Age Months;Allergic;allergic airway inflammation;Anti-Inflammatory Agents;Asthma;asthmatic;atopy;Bacteria;Biological Assay;Birth;Cells;Child;Childhood;Clinical;cohort;Cohort Studies;Communication;County;cytokine;Development;Disease;Disease Outcome;disorder prevention;disorder risk;dysbiosis;Early identification;Ecosystem;Environment;Epithelium;Exhibits;Extrinsic asthma;Family;Feces;Fostering;Foundations;Frequencies;gastrointestinal;Genes;Goals;gut microbes;gut microbiome;gut microbiota;Health;high risk;high risk infant;Human;Hypersensitivity;IL4 gene;Immune;immune function;Immune response;Immune Tolerance;Immunity;immunoregulation;In Vitro;individualized prevention;infancy;Infant;infant gut microbiome;Inflammatory;Knowledge;Life;Longitudinal cohort study;Longitudinal Studies;Macrophage;Meconium;Metabolic;Metabolic dysfunction;microbial;microbial colonization;microbiome;microbiota;Modeling;Mothers;Mus;Nature;neonate;novel;Outcome;Parents;Pathway interactions;Pattern;Phenotype;Play;Polyunsaturated Fatty Acids;Population;Predisposition;Prevention;Primary Prevention;Process;Production;Productivity;programs;promote resilience;prospective;Recording of previous events;Regulatory T-Lymphocyte;Relative Risks;repaired;resilience;Risk;Risk Reduction;Role;Sampling;Shapes;Source;stool sample;success;Testing;Th2 Cells;transmission process;Vertical Disease Transmission

PROJECT_TITLE: Project 3   Identification of Microbial Founder Species and Metabolic Products that Promote Microbiota and Immune Development Resilient to Childhood Allergy and Asthma


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Genetics;Lung;Microbiome;Nutrition;Pediatric;Precision Medicine;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

PI_NAMEs: JOHNSON, CHRISTINE C  (contact)

PROJECT_TERMS: 10 year old;2 year old;Accounting;Address;Adult;Affect;Age;age group;Allergens;Allergic;Allergic Disease;Antibiotics;Asthma;Behavioral;Birth;Breast Feeding;Categories;Characteristics;Child;Childhood;Chronic;Clinical;cohort;Collection;Communities;Complex;cost efficient;County;Data;design;Development;Diagnosis;Diet;Disease;Economics;Electronic Health Record;Environment;Environmental Exposure;environmental tobacco smoke;epidemiology study;ethnic diversity;Ethnic Origin;Extrinsic asthma;falls;First Pregnancy Trimester;Food;Freezing;Funding;Future;Genetic;Genetic Risk;gut microbes;gut microbiota;Health;Health Status;Health system;high risk;high risk population;Home;Hypersensitivity;IgE;Immune;Immune system;indexing;individualized prevention;infancy;Infant;Inhalant dose form;inner city;innovation;Institution;Intervention;Intuition;Late pregnancy;Life;Longitudinal cohort study;Longitudinal Studies;Marital Status;maternal microbiota;Mediating;Medicine;Microbe;microbial;microbial community;microbiota;modifiable risk;Mothers;Multivariate Analysis;Mus;Nature;Nested Case-Control Study;Odds Ratio;offspring;Outcome;Paper;Pathway interactions;Pattern;pet animal;Phenotype;Physicians;postnatal;Pregnancy;Pregnant Women;prenatal;Prevalence;Preventive;preventive intervention;Primary Prevention;Process;Publications;pulmonary function;Race;racial diversity;Recording of previous events;recruit;Reporting;Research;Research Design;resilience;Risk;Risk Factors;risk variant;sample collection;Sampling;Serum;sex;social;sociodemographics;stool sample;Subgroup;Techniques;Technology;Time;vaginal microbiota;Visit;Work

PROJECT_TITLE: Project 1  Early Microbiota-Related Risk Factors and the Development of a Multi-Sensitized High Risk for Allergic Asthma Phenotype


PI_NAMEs: OWNBY, DENNIS R (contact)

PROJECT_TERMS: Accounting;Agreement;Allergens;American;Antibodies;Bar Codes;Biological Assay;Biostatistics Core;Caring;Certification;Childhood;CLIA certified;Clinical;cohort;Collaborations;college;Communication;Complete Blindness;Computer software;Computers;Containment;Core Facility;cost;cost efficient;Credentialing;Data;data quality;Databases;Dry Ice;Electronic Mail;encryption;Enzyme-Linked Immunosorbent Assay;Equipment;experience;Extrinsic asthma;Freezing;Future;Grant;Hazardous Substances;Health system;Human;Hypersensitivity;IgE;Immunology;Individual;individualized prevention;instrument;Laboratories;medical schools;Methods;microbiota;Minor;Names;Participant;Pathologist;pediatric department;Performance;Personal Computers;preservation;Procedures;programs;Protocols documentation;quality assurance;Reader;Reagent;recruit;Reporting;Research;Research Personnel;research study;Resources;Sampling;Scanning;Secure;Serum;Shipping;square foot;System;systems research;Testing;Time;Training;Universities;Variant;Woman;Work

PROJECT_TITLE: Core E  Immunoglobulin E Analysis Core


PROJECT_TERMS: 16S ribosomal RNA sequencing;Asthma;Bacteria;Biological Assay;Biological Markers;Collaborations;Communities;Data;Development;DNA Sequencing Facility;Ensure;Equipment;Extrinsic asthma;Genetic Markers;Genomic DNA;high risk;Human Resources;indexing;individualized prevention;Infant;maternal microbiome;Methods;microbial;microbial community;microbiome;microbiota;microbiota composition;microbiota profiles;next generation;next generation sequencing;Nucleic Acids;Publishing;Qualifying;Research Personnel;Resolution;Ribosomal RNA;Risk;Sampling;Standardization;Structure;synergism;Taxonomy;Variant

PROJECT_TITLE: Core D  Microbial Community Analysis Core


NIH_SPENDING_CATS: Asthma;Breastfeeding, Lactation and Breast Milk;Clinical Research;Lung;Microbiome;Precision Medicine;Prevention

PI_NAMEs: WOODCROFT, KIMBERLEY J (contact)

PROJECT_TERMS: arm;Asthma;biobank;Biological;Birth;Blood;Clinical Trials;cohort;Collection;Core Facility;DNA;Doctor of Philosophy;Dust;Enrollment;experience;Extrinsic asthma;Feces;Future;Goals;Human Milk;Hypersensitivity;IgE;individualized prevention;Laboratories;Laboratory Research;Leadership;Lipids;Mass Spectrum Analysis;Michigan;Microbe;microbial community;microbiome analysis;microbiota;Molecular Epidemiology;Monitor;Observational Study;Participant;participant retention;Patient Recruitments;pet animal;Plasma;Process;Protocols documentation;recruit;repository;Research;RNA;Sampling;skills;Specimen;Swab;Universities;Urine

PROJECT_TITLE: Core C  Cohort Administration and Biospecimen Core


PI_NAMEs: LI, JIA  (contact)

PROJECT_TERMS: Address;Allergic;Asthma;asthmatic;Biometry;central database;Child;Code;cohort;Cohort Studies;Collaborations;Communication;Communities;computerized data processing;County;Data;Data Analyses;data integrity;data management;data quality;data repository;Data Storage and Retrieval;Database Management Systems;Databases;design;Development;Documentation;Ensure;Environment;experience;Extrinsic asthma;Funding;Health;high dimensionality;high risk;high standard;Hypersensitivity;Individual;individualized prevention;Infrastructure;innovation;Intervention;Laboratories;Literature;Longitudinal Studies;Manuscripts;maternal risk;Medical Records;meetings;member;Methodology;Methods;microbiome;microbiome analysis;microbiota;Monitor;Mothers;Nested Case-Control Study;Participant;Perinatal;postnatal;Predisposition;prenatal;Preparation;Principal Investigator;Publications;Questionnaires;Recording of previous events;Reproducibility;Research;Research Personnel;Risk;Route;Sampling;Schedule;Secure;sound;Statistical Methods;Structure;Subjects Selections;System;temporal measurement;Testing;Time;tool;Training;web site;Writing

PROJECT_TITLE: Core BBiostatistics and Data Management Core


PROJECT_TERMS: Accounting;Address;Advisory Committees;California;Charge;Child;Childhood;Collaborations;Communication;Communication Barriers;Communities;Data;data sharing;Development;Disadvantaged;Discipline;Documentation;Effectiveness;Ensure;Epidemiology;experience;Extrinsic asthma;Fostering;Geography;Grant;gut microbiota;Health;Health system;Human Resources;Immune;Immune system;Immunologics;individualized prevention;Influentials;Information Dissemination;innovation;Institution;Institutional Review Boards;Investigation;Learning;Life;Manuscripts;Medical;meetings;Methodology;Michigan;microbiota;Monitor;Mothers;Newborn Infant;Output;Physiological;Process;Productivity;programs;Progress Reports;Publications;Research;Research Activity;Research Personnel;Risk;Risk Reduction;Sampling;San Francisco;Schedule;synergism;Travel;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Core A   Administrative Core


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Chronic Obstructive Pulmonary Disease;Clinical Research;Health Services;Lung;Lung Cancer;Prevention

PHR: Public Health Relevance Currently, there is little knowledge regarding a possible threshold where the benefits of finding early-stage lung cancer no longer outweigh the risk of dying due to a competing cause. Our proposed study has direct value for advancing public health by examining real-world, timely data on the outcomes of LCS.

PI_NAMEs: BRAITHWAITE, DEJANA K (contact);GOULD, MICHAEL K;SILVESTRI, GERARD A

PROGRAM_OFFICER_NAME: MARCUS, PAMELA M

PROJECT_TERMS: Adult;Age;American Cancer Society;Assessment tool;Attention;Cancer Etiology;Cancer Intervention;Cancer Patient;cancer surgery;Cessation of life;Chronic;Chronic Obstructive Pulmonary Disease;clinical practice;Clinical Trials;comorbidity;compare effectiveness;Data;data integration;data standards;Decision Making;Diagnosis;Diagnostic Procedure;Disease;Early Diagnosis;early screening;Elderly;Electronic Health Record;Eligibility Determination;Ethnic Origin;former smoker;Funding;Geography;Goals;Health;high risk;Impairment;improved;Infrastructure;Intervention;Knowledge;Life Expectancy;Link;low dose computed tomography;Lung;lung cancer screening;Malignant neoplasm of lung;meetings;member;Modeling;models and simulation;Morbidity - disease rate;multiple chronic conditions;Observational Study;Outcome;Participant;patient oriented;patient population;Patients;personalized screening;Persons;Policies;Population;Procedures;Prospective cohort;Provider;Public Health;public health relevance;Pulmonary Emphysema;pulmonary function;Race;randomized, clinical trials;Recommendation;repository;Retrospective cohort;Risk;Risk Factors;routine screening;screening;screening guidelines;simulation;Smoker;Smoking History;Socioeconomic Status;Spottings;Therapeutic procedure;Thoracic Radiography;Time;Uncertainty;Work

PROJECT_TITLE: Personalized screening for lung cancer: the importance of co-existing chronic conditions to clinical practice and policy

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: LAY SUMMARY Overactivation of the inflammatory response underlies a multitude of inflammatory diseases, and the Abbott lab attempts to identify novel proteins that can be targeted pharmaceutically to halt these diseases. To this end, we have identified small molecule inhibitors of the kinase, RIPK2, a key inflammatory kinase. The current application aims to extend this work by studying the kinase activity of RIPK2. Which proteins does it phosphorylate? Which signaling pathways does it influence, and can we identify clinical scenarios in which its inhibition would help ameliorate disease? Answers to these questions are important as our RIPK2 inhibitors move into patients.

PI_NAMEs: ABBOTT, DEREK W (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Adaptive Immune System;Applications Grants;Bacterial Infections;bone;Cells;chemical genetics;Chemicals;Clinic;Clinical;Complex;cytokine;Databases;Disease;Drug Targeting;dysbiosis;Goals;Hyperactivity;Immune signaling;immunodeficiency;Inflammation;Inflammatory;Inflammatory Response;inhibitor;kinase inhibitor;Mass Spectrum Analysis;novel;pathogen;Pathway interactions;patient population;Patients;pharmacologic;phosphoproteomics;Phosphorylation;Phosphotransferases;Proteins;response;RIPK2 gene;Signal Pathway;Signal Transduction;small molecule inhibitor;Specificity;success;System;tool;Work

PROJECT_TITLE: Innate Immune signal transduction specificity in inflammatory disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Infectious Diseases;Pediatric;Prevention

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Environmental agents are important for triggering autoimmune diseases such as Type 1 Diabetes (T1D). This project seeks to determine whether Cytomeglovirus infection is the triggering agent for T1D. The work will lead to new anti-viral treatments for preventing T1D.

PI_NAMEs: SARVETNICK, NORA E (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Acceleration;Advocate;Anti-viral Response;Anti-viral Therapy;antigen-specific T cells;Antigens;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;autoreactive T cell;autoreactivity;Biological;Biological Markers;C-Peptide;CD8-Positive T-Lymphocytes;CD8B1 gene;Cesarean section;Child;chronic infection;Clinic;Clinical;Collaborations;cost;Coxsackie Viruses;Cross Reactions;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Vaccines;Detection;Development;diabetes risk;Disease;environmental agent;Environmental Risk Factor;Etiology;Event;exhaust;Exogenous Factors;Frequencies;Genetic;Genetic Risk;genetic risk factor;Haplotypes;Human;human disease;Hygiene;IA-2 antibody;Infection;Insulin-Dependent Diabetes Mellitus;Investigation;islet;Islets of Langerhans;Kinetics;Longitudinal Studies;Measurement;Measures;Mediating;microbiome;Monozygotic twins;Nutrient;Pathway interactions;pre-clinical;preclinical development;Predisposition;prevent;Prevention;Probability;Process;prospective;PTPN22 gene;Reagent;Reporting;response;Risk;Role;Sampling;seroconversion;seropositive;Siblings;Specificity;Sunlight;T-Lymphocyte;T-Lymphocyte Subsets;Testing;TNFRSF10A gene;vaccine trial;Variant;Viral;Viral Proteins;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: CMV responses in autoantibody positive subjects advocate antiviral treatments for prevention of T1D

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-H(02)]


ORG_CITY: BUFFALO

ORG_NAME: VA WESTERN NEW YORK HEALTHCARE SYSTEM

PHR: Many Veterans who have cardiovascular diseases (CVDs) still smoke cigarettes or drink too much alcohol, which worsens these diseases. The VA has many programs and treatments available for Veterans who are ready and willing to change these behaviors, but there are many patients who are not yet ready. Patient- aligned care teams (PACTs), which include primary care mental health integration (PCMHI) providers, are the ideal setting to reach Veterans who are not ready to change smoking or hazardous drinking and discuss ways to increase readiness. Helping Veterans understand the risks of these behaviors, the possible benefits of changing, and how and why they engage in these behaviors is key to increasing readiness and intention to change; this intervention can occur during a Veteran's already-scheduled PACT appointment for optimal convenience. Incorporating Veterans' and providers' treatment preferences will enhance the intervention is acceptable, Veteran-centered, and able to be successfully implemented into real-world PACT clinical practice.

PI_NAMEs: GASS, JULIE C (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;Alcohols;Appointment;Area;Behavior;behavior change;Behavior Therapy;Behavioral;behavioral health;behavioral health intervention;brief intervention;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;career;Caring;Charge;cigarette smoke;Client satisfaction;Clinical;clinical practice;comorbidity;Data;Data Analyses;design;Development;Diagnosis;Disease;drinking;Education;Educational Intervention;effectiveness study;efficacy evaluation;Elements;Ensure;Evaluation;Event;evidence base;Evidence based intervention;experience;Feedback;Funding;Future;hazardous drinking;Health;Health Care Costs;health care service;Health Personnel;Healthcare;improved;Intention;Intervention;intervention refinement;Intervention Trial;Interview;K-Series Research Career Programs;Literature;Longevity;Manuals;Medical;Medical Care Team;member;Mental Health;mental health center;Mental Health Services;Mentorship;Methodology;Modification;Monitor;mortality;Motivation;Nurses;Outcome;Patient Care;Patient Care Team;patient oriented;Patient Schedules;Patients;pilot test;pilot trial;Postdoctoral Fellow;preference;Primary Care;primary care patient;primary care provider;programs;Provider;Psychologist;Psychophysiology;Readiness;Recommendation;Reporting;Research;Research Personnel;Research Proposals;Review Literature;Risk;Risk Behaviors;Risk Factors;Risk Reduction;routine screening;Sampling;Self Efficacy;Self Management;Services;skills;Smoke;Smoker;Smoking;smoking cessation;smoking intervention;substance use;substance user;successful intervention;Team Process;team-based care;Techniques;Testing;therapy design;therapy development;Time;Tobacco;Tobacco use;Training;treatment program;Treatment Protocols;Trust;Veterans;willingness;Work

PROJECT_TITLE: Developing a Team-Delivered Intervention for Smoking and Hazardous Drinking for Primary Care Veterans with Cardiovascular Diseases

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


NIH_SPENDING_CATS: Cancer;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Immunotherapy;Infectious Diseases;Rare Diseases

ORG_NAME: LSU HEALTH SCIENCES CENTER

PHR: NARRATIVE In many cancers, a clear understanding of the tumor microenvironment including the presence, antigen- specificity and functionality of tumor-infiltrating lymphocytes (TILs) is revolutionizing therapeutic approaches. Yet for KS we have a dearth of information about the nature of TILs and whether the tumor microenvironment is suppressing their anti-neoplastic function in an HIV-1 dependent manner. This project seeks to rectify this knowledge gap in a Case (HIV-1+/KS+) versus Control ((HIV-1+/KS-) design by comparatively investigating the phenotypes and the functionality of TILs in comparison to the same cells in the peripheral immune system and by comparing the tumor and peripheral immune cell expression patterns.

PI_NAMEs: WEST, JOHN T. (contact);WOOD, CHARLES

PROGRAM_OFFICER_NAME: KALEEBA, JOHNAN AUGUSTINE

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;African;AIDS with Kaposi's sarcoma;American;anergy;Antigens;Antineoplastic Agents;antiretroviral therapy;Autologous;Automobile Driving;B-Lymphocytes;cancer infiltrating T cells;CD14 gene;CD4 Lymphocyte Count;Cd68;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;checkpoint inhibition;Chemotactic Factors;co-infection;Collaborations;Communities;comparative;CXCL9 gene;cytokine;Cytomegalovirus;Data;Defect;design;Development;Diagnosis;Disease;Effector Cell;Environment;Etiology;Evaluation;exhaustion;Expression Profiling;Failure;Herpesviridae Infections;HIV;HIV-1;Human Herpesvirus 4;Human Herpesvirus 8;Iatrogenesis;illness length;Immune;immune reconstitution;Immune system;Immunity;Immunodominant Antigens;Immunologics;Immunophenotyping;Immunosuppression;Immunotherapeutic agent;Incidence;Individual;Infiltration;Inflammatory;Influenza;Interleukin-10;Intervention;Investigation;Kaposi Sarcoma;Knowledge;Leucocytic infiltrate;Macrophage;Malignant Neoplasms;Memory;men;Molecular;Nature;Neoplasms;neoplastic;patient stratification;Patients;Pattern;Peptides;Peripheral;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Population;Process;programs;Resected;response;Role;senescence;skin biopsy;Sorting;Specificity;Suspensions;synergism;T cell differentiation;T cell response;T-Lymphocyte;Teaching Hospitals;Testing;Therapeutic;Tissues;transcriptome;transcriptome sequencing;tumor;tumor microenvironment;Tumor Tissue;Tumor-Infiltrating Lymphocytes;Universities;Vaccines;Viral;Woman;Zambia

PROJECT_TITLE: KSHV,HIV and the Kaposi's Sarcoma Tumor Niche


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE This project aims to identify new driver genes and potential therapeutic targets in the Group 3 subtype of medulloblastoma, which is an aggressive pediatric brain cancer with poor outcomes. This career development grant will provide the applicant with research training to investigate the non-canonical protein, ASNSD1 uORF, as a novel Group 3 medulloblastoma driver gene. The information gained by this project will enable future study of ASNSD1 uORF as a potential therapeutic target in Group 3 medulloblastoma and demonstrate the importance of non-canonical proteins as disease driver genes.

PI_NAMEs: PRENSNER, JOHN  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: 5' Untranslated Regions;Acceleration;Advisory Committees;Area;authority;Award;Binding;Biological Models;Cancer Biology;cancer cell;career;career development;Cell Line;Cell Physiology;Cell Survival;Cells;Cerebellum;Child;Childhood;Childhood Brain Neoplasm;Childhood Malignant Brain Tumor;clinically relevant;Code;Complex;Computational Biology;Computer Analysis;Dana-Farber Cancer Institute;Data;Disease;disease model;Electroporation;Environment;Evaluation;Exclusion;experience;fetal;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Predisposition to Disease;Genomics;Goals;Grant;Growth;Growth and Development function;high risk;Human;Human Genome;Human Genome Project;Immunohistochemistry;improved;in utero;In Vitro;in vivo;in vivo Model;Institution;instructor;Investigation;K-Series Research Career Programs;Knock-out;Knowledge;Lethal Genes;Maintenance;Malignant Neoplasms;Mediator;Medulloblastoma;medulloblastoma cell line;member;Mentors;Mentorship;Messenger RNA;Modeling;mortality;mouse model;Mus;nerve stem cell;neural;neuro-oncology;novel;novel strategies;Oncogenic;Oncologist;Open Reading Frames;Outcome;Pathogenesis;Patient Care;Patient-Focused Outcomes;Phenotype;Physicians;Positioning Attribute;Post-Transcriptional Regulation;prefoldin;programs;Proliferating;Proteins;Proteome;Proteomics;Regulation;Research;research and development;Research Personnel;Research Training;Role;Scientist;Serum;skills;stem;Support System;symposium;Techniques;Testing;Therapeutic;therapeutic target;Time;Training;training opportunity;Translations;Treatment Protocols;tumor;tumorigenesis;United States National Institutes of Health;Work;Xenograft procedure

PROJECT_TITLE: Deciphering non-canonical translation in high risk medulloblastoma


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Although multiple national efforts have been introduced to address Veteran suicide, Veteran suicide rates remain high and are elevated compared with the general population. Systematic reviews have identified few interventions that effectively decrease suicide risk. One promising area for intervention is social connectedness, which has been identified as a strong protective factor. However, little research has been done on interventions that directly target social connectedness. Studies also suggest that supported engagement with community activities is associated with positive mental health outcomes, but such strategies have not been studied among Veterans. The current project proposes to develop and pilot a multicomponent, peer- support facilitated intervention for increasing social connectedness through participation in community activities among Veterans at elevated risk of death by suicide.

PI_NAMEs: CHEN, JASON I (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Administrator;Area;Award;Awareness;Behavior;career;Clinical;Clinical Trials;Collaborations;Communication;Communities;community center;community collaboration;community engagement;Community Integration;Competence;Conduct Clinical Trials;Data;Development;Doctor of Philosophy;Dropout;effective intervention;efficacy evaluation;Evaluation;Family;Friends;Future;General Population;Goals;Health Services;Health Services Research;high risk;high risk population;Homogeneously Staining Region;Hospitalization;Hybrids;implementation barriers;implementation science;improved;Individual;inpatient psychiatric treatment;Intervention;Interview;K-Series Research Career Programs;Lead;Learning;Life;Manuscripts;meetings;member;Mental Health;Mental Health Services;Mentors;Mentorship;Methodology;mortality risk;Motivation;multi-component intervention;Nonprofit Organizations;operation;Outcome;Pathway interactions;peer support;Perception;pilot trial;Population;preference;Preparation;Program Development;protective factors;psychiatric inpatient;Psychiatrist;Psychiatry;Psychological Theory;Qualitative Methods;Randomized;reducing suicide;Reporting;Research;Research Activity;Research Personnel;Resources;Risk;Site;skills;social;social contact;Social support;Special needs;Specialist;stressor;Structure;Students;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide prevention;suicide rate;System;systematic review;therapy design;therapy development;Time;Training;treatment risk;tutoring;Veterans;volunteer

PROJECT_TITLE: Enhancing Social Connectedness Among Veterans at High Risk for Suicide through Community Engagement


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Epilepsy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Electrographic seizures (ESz) and some epileptiform abnormalities (e.g. high-frequency periodic discharges HF-PD) captured on continuous EEG (cEEG) are common after severe traumatic brain injury (sTBI) and are associated with supply-demand mismatch, in-hospital neurologic deterioration, and outcome in a variety of conditions. A gap in knowledge exists in the treatment of sTBI patients regarding whether ESz and HF-PD result in secondary brain injury and respond to anti-seizure drug treatment. The goal of this project is to link the relationship between established biomarkers of metabolic demand (PbtO2), EEG abnormalities (ESz and HF- PD), clinical outcome, and treatment, to identify dynamic EEG biomarkers of secondary injury that will power future interventional trials targeting hypermetabolism to improve functional outcomes for sTBI patients.

PI_NAMEs: DING, KAN ;GILMORE, EMILY  (contact);ROSENTHAL, ERIC S.

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acute;Acute Brain Injuries;Advocate;Anesthetics;Anticonvulsants;Biological Markers;Brain;Brain Hypoxia;Brain Injuries;Brain region;brain tissue;cerebral atrophy;Cerebrum;Clinical;clinical effect;clinical efficacy;Clinical Treatment;Clinical Trials;Clinical Trials Network;cohort;Complex;Coupled;Critical Care;Delirium;density;design;Detection;Deterioration;Early Mobilizations;Electroencephalography;Electrographic Status Epilepticus;Emergency Care;Energy Supply;epileptiform;Event;experience;Exposure to;Failure;Frequencies;functional disability;functional improvement;functional outcomes;Future;Glasgow Coma Scale;Glasgow Outcome Scale;Goals;Hospitals;Hypoxia;improved;improved outcome;Infrastructure;Infusion procedures;Injury;innovation;Intervention;Intervention Trial;Intracranial Hypertension;Intracranial Pressure;Knowledge;Length of Stay;Link;long-term sequelae;Measurable;Measures;Mechanical ventilation;Metabolic;Metabolism;Modeling;Monitor;Multi-Institutional Clinical Trial;multimodality;Neurologic;Neurons;neurophysiology;Outcome;Outcome Measure;Oxygen;Partial Pressure;Patient Monitoring;Patient Selection;Patient-Focused Outcomes;Patients;Periodicals;Pharmacotherapy;Phase;phase III trial;Population;Post-Traumatic Epilepsy;pressure;programs;prospective test;Randomized, Controlled Trials;Research;response;Risk;Sedation procedure;Seizures;signal processing;Site;standard of care;Structure;TBI Patients;TBI treatment;Therapeutic Intervention;tissue oxygenation;Tissues;Trauma recovery;Traumatic Brain Injury;treatment guidelines;Treatment Protocols;treatment response;treatment strategy;treatment trial;trend;Work

PROJECT_TITLE: ELECTRO-BOOST: Electroencephalography for cerebral trauma recovery and oxygenation


ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: PA

PHR: The number of women in the United States dying during or around pregnancy has been increasing for the past thirty years. Women from racial and ethnic minorities, women who live in rural areas, and women with low- income have a higher risk than other women of dying during or around pregnancy. Many of these deaths are related to pre-existing chronic health conditions and may be preventable by improving women’s health before they become pregnant. Women Veterans have a high prevalence of chronic medical and mental health conditions; little is known about their maternal outcomes. This project will use quantitative and qualitative research methods to understand how women Veterans’ pre-pregnancy health conditions, social characteristics, healthcare experiences, and maternal outcomes are linked. This critical new information will be used to design interventions that improve women’s pre-pregnancy health and reduce the incidence of adverse maternal outcomes, including maternal death.

PI_NAMEs: QUINN, DEIRDRE A (contact)

PROJECT_TERMS: acceptability and feasibility;Acute;adverse maternal outcomes;Age;Area;Attitude;Birth;black women;care coordination;career;Caring;Cessation of life;child bearing;Chronic;Classification;Clinical;cohort;comorbidity;Data;design;Development;Disparity;disparity reduction;Disproportionately impacts women;Eclampsia;effective intervention;Equity;ethnic minority;Ethnic Origin;Etiology;Event;experience;Feedback;follow-up;Future;Goals;Health;health care delivery;health care service;health equity;Health equity research;Health Services;Health Services Accessibility;Healthcare;Heart failure;High Prevalence;high risk;improved;Incidence;informant;innovation;integrated care;Intervention;Interview;Knowledge;Leadership;Link;Literature;Low income;Maternal Health;maternal morbidity;Maternal Mortality;maternal outcome;Medical;Mental Health;Mentorship;Methodology;multi-component intervention;Not Hispanic or Latino;operation;patient oriented;Patients;Pattern;Pilot Projects;pilot test;Policies;Population;Postdoctoral Fellow;Poverty;preference;Pregnancy;Pregnancy Complications;pregnancy health;Pregnancy Rate;pregnancy related death;pregnant;prepregnancy;Prevalence;Prevention;Primary Care;programs;Provider;Qualitative Research;Race;racial discrimination;racial minority women;recruit;Reproductive Health;reproductive outcome;Research;Research Methodology;Research Personnel;Research Priority;Risk;Risk Factors;Role;rural area;rural residence;rurality;Sampling;Sepsis;severe maternal morbidity;Site;Social Characteristics;social factors;Strategic Planning;Stroke;Structure;Subgroup;telephone based;Testing;therapy design;therapy development;Training;United States;Variant;Veterans;White Women;Woman;women of color;Women's cohort;Women's Health;Women's Health Services;women's outcomes;Work

PROJECT_TITLE: Examining Pre-Pregnancy Health and Maternal Outcomes among Women Veterans


ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: The Chronic Effects of Neurotrauma Consortium (CENC; W81XWH-13-2-0095) has been a highly productive, coordinated, multicenter, basic science-to-bedside, research collaboration led by VCU/VA researcher David Cifu, MD and jointly funded since 2013 by the DoD and VA. CENC linked basic, translational, epidemiologic, and clinical neuroscience researchers from the VA, military, academia, and private sector to effectively address the diagnostic challenges and therapeutic ramifications of mild traumatic brain injury (mTBI) and its potential long-term effects. Experienced and proven researchers from the CENC comprise the LIMBIC team at the level of Consortium Leadership, Core Facility, and Research Study Directors. This proven team of leaders, infrastructure supporters and researchers will initiate targeted, expanded research studies that extend CENC research findings, address all priorities (required and secondary research elements) detailed in the program announcement, and will produce deliverables for the clinicians in the field.

PI_NAMEs: PUGH, MARY JO  (contact)

PROJECT_TERMS: Academia;Acute;Address;Area;Basic Science;Biological Markers;Biometry;Biostatistics Core;Brain;Brain Injuries;care systems;Caring;Characteristics;Chronic;Chronic Care;chronic pain;Clinical;Clinical Research;cohort;Collaborations;combat;comorbidity;Core Facility;Data;data management;Data Security;Dementia;Diagnostic;Elements;Enrollment;Epidemiology;experience;Family member;follow-up;Functional disorder;Funding;Funding Mechanisms;General Population;Guidelines;Head;health economics;Healthcare;improved;Infrastructure;Knowledge;knowledge translation;Late Effects;Leadership;Link;Long-Term Effects;Mental Health;mild traumatic brain injury;Military Personnel;Mission;Nature;Nerve Degeneration;Nervous System Trauma;Neurocognitive Deficit;Neurodegenerative Disorders;neuroimaging;Neurologic;Neurologic Signs;Neurosciences;neurosensory;NIH Program Announcements;Outcome;Pain;patient oriented;Phenotype;Population;Population Characteristics;Post-Traumatic Stress Disorders;Prevalence;Private Sector;Productivity;protective factors;Quality Control;Research;Research Personnel;research study;Risk Factors;Sensory Disorders;service member;Sleep;Support System;Symptom Burden;Symptoms;Therapeutic;Time;tool;Veterans;Woman;Work

PROJECT_TITLE: VA-DoD Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC): Data and Biostatistics Core

STUDY_SECTION: RRDB

STUDY_SECTION_NAME: Brain Injury[RRDB]


ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

PHR: PTSD is one of the most common mental health conditions affecting Veterans and is associated with significant burden. Highly effective treatments exist for PTSD, evidence-based psychotherapies, but very few Veterans receive them. Although VA has trained over 8,500 providers in evidence-based psychotherapies for PTSD over the past 10 years, only 6% of the 650,000 VHA patients with PTSD receive an evidence-based psychotherapy. It is critical that we connect Veterans with our most effective PTSD treatments and that we do so in a way that is Veteran-centered. Shared decision making is a patient-centered approach to choosing healthcare treatment options. It has been shown to increase patients’ motivation for treatment and ability to stay in treatment long enough to get benefit. It has also been shown to help providers align their practice with evidence-based guidelines. This proposal will refine and pilot test a shared decision making intervention for PTSD to be used in VA primary care clinics, where the vast majority of Veterans with PTSD are treated.

PI_NAMEs: CHEN, JESSICA ANN (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Appointment;Belief;Benefits and Risks;career;Caring;Characteristics;Clinic;Clinical;clinical care;clinical practice;Collaborations;Data;Decision Making;design;Diagnosis;Education;effective therapy;Effectiveness;effectiveness testing;effectiveness/implementation trial;Emotional;Enrollment;Ensure;ethnic minority;Ethnic Origin;evidence base;evidence based guidelines;Evidence based treatment;Familiarity;Feasibility Studies;feasibility trial;Funding;Future;Gender;Goals;Growth;Health Personnel;Health Services;Health Services Accessibility;Health Services Research;Healthcare;Hybrids;implementation barriers;implementation evaluation;implementation facilitators;implementation science;improved;innovation;integrated care;Intervention;Interview;Investments;Knowledge;Lived experience;Manuals;Measures;medical specialties;Mental Depression;Mental Health;Mental Health Services;Mentors;Mentorship;Methodology;Methods;Motivation;Outcome;Patient Compliance;patient oriented;Patient Preferences;patient-level barriers;Patients;Performance;Pharmaceutical Preparations;pilot test;pilot trial;Post-Traumatic Stress Disorders;preference;Primary Care;primary care clinic;primary care patient;Procedures;Process;Protocols documentation;Provider;provider-level barriers;Psychologist;Psychotherapy;Race;racial minority;Randomized;randomized trial;Readiness;recruit;Research;Research Activity;Research Methodology;Research Personnel;Research Priority;Research Support;research to practice;Risk;Risk Factors;Role;Rural;rural health clinic;rurality;Sampling;Self Efficacy;Services;shared decision making;Site;Suicide;Suicide prevention;Surveys;telehealth;Testing;Time;Training;Training Activity;treatment as usual;treatment planning;Trust;United States National Institutes of Health;user centered design;Veterans;Visit;web based decision aid;Woman;Work

PROJECT_TITLE: Patient Readiness for Improvement through Motivation, Engagement, and Decision-making for PTSD (PRIMED-PTSD)


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Precision Medicine;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PHR: PROJECT NARRATIVE (lay abs) The mortality gap between African Americans and Whites with breast cancer in the US reflected the unmasking of differences in the biology of breast cancer between AA and WA women related to targeted therapies. Our previous findings implicated African alleles of the DARC gene in etiology of breast cancer phenotypes and its tumor expression with survival, suggesting ancestry-related differences in tumor immunological responses that may stratify patients for improved use of immunotherapy treatments to decrease tumor-subtype-related disparities in mortality. Our proposed work will define the clinical associations of DARC in African breast cancer patients and “DARC tumor” characteristics that will give insight to shared genetic risk among women of the African diaspora who share unique burdens of aggressive breast tumor phenotypes.

PI_NAMEs: DAVIS, MELISSA B (contact);NEWMAN, LISA A.

PROGRAM_OFFICER_NAME: DUGLAS TABOR, YVONNE

PROJECT_TERMS: 3-Dimensional;Affect;Africa;African;African American;African American population;African American Women;African ancestry;African Caribbean;African Women;Age;Alleles;Anthropology;Area;Automobile Driving;Biodiversity;Biology;Breast Cancer Patient;Breast Cancer Treatment;cancer genome;cancer health disparity;cancer subtypes;caucasian American;cell behavior;cell type;Cells;Characteristics;Clinical;cohort;comorbidity;Country;Coupled;Cytometry;Data;Data Set;Death Rate;Diabetes Mellitus;Diagnosis;Disease;Disparity;DNA;Epithelium;Equitable healthcare;Ethiopia;Etiology;Gene Expression;Gene Expression Profile;gene network;Genes;Genetic;Genetic Risk;genetic variant;Genetic Variation;genome sequencing;Genomics;Germ Lines;Ghana;health outcome disparity;Heterogeneity;High Prevalence;Immune;immune cell infiltrate;Immune response;Immunologics;Immunotherapy;improved;In Situ;Incidence;Individual;Infiltration;Inflammation;Inflammatory;inflammatory marker;innovation;insight;Investigation;Kenya;Latinx;Leucocytic infiltrate;Leukocytes;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Modeling;mortality;mortality disparity;multi-ethnic;multidisciplinary;Multiomic Data;multiple omics;multiplexed imaging;Myelogenous;neoplastic cell;Nigeria;North African;novel;Obesity;Organoids;Outcome;Pathologic;Pathologist;Pathology;Pathway interactions;Patient Self-Report;patient stratification;Patients;Pattern;personalized care;Phenotype;Population;population based;Population Genetics;Population Heterogeneity;Primary Neoplasm;Privatization;prognostic;prospective;Proteins;Proteomics;Race;racial population;recruit;Regulation;Reporting;response;Risk;Side;Stage at Diagnosis;Surgical Oncologist;Survival Rate;targeted treatment;Tissue-Specific Gene Expression;transcriptome;transcriptome sequencing;translational study;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Biology;tumor heterogeneity;tumor microenvironment;Tumor Subtype;tumor-immune system interactions;Tumor-infiltrating immune cells;Variant;whole genome;Woman;Work

PROJECT_TITLE: The DARC side of Breast Cancer Disparities - African Ancestry and Cancer- Related Immune Response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-B(55)R]


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: The incidence of post-traumatic stress disorder (PTSD) among combat-experienced Veterans is much larger than the general population. Moreover, 50% of Veterans with PTSD are also diagnosed with substance use disorders (SUDs). Patients with comorbid PTSD and SUDs show poorer treatment outcomes than patients diagnosed with either disorder alone. This special need of Veterans is largely unaddressed by preclinical research. Cannabis and opioids are among the addictive drugs most widely abused by Veterans, and we employ cannabis or heroin use and life-threatening acute stress in rats to study the neurological mechanisms PTSD/SUDs comorbidity. In the first funding period we discovered that cannabis use exacerbates responses to conditioned stress. Going forward we expect to identify brain circuits and molecular mechanisms underlying the synergisms between stress and cannabis that can be exploited as targets for treating the high incidence of comorbid PTSD and SUDs in our returning combat Veterans.

PI_NAMEs: KALIVAS, PETER W (contact)

PROJECT_TERMS: Acute;Acute Post Traumatic Stress Disorder;acute stress;Alcohols;Astrocytes;Award;Behavior;Behavioral;behavioral study;biological adaptation to stress;Brain;brain circuitry;Brain imaging;Calcium;Cannabis;cannabis seeking;cannabis self-administration;Cell Nucleus;Cells;Characteristics;Clinical;clinically relevant;Cocaine;cocaine seeking;combat;combat veteran;comorbidity;Conditioned Reflex;conditioning;Coping Behavior;Cue-induced relapse;Cues;Dendrites;design;Diagnosis;Diagnostic;Disease;drug craving;Drug usage;DSM-V;experience;Extracellular Matrix;Funding;Future;GABA transporter;gamma-Aminobutyric Acid;General Population;Globus Pallidus;Glutamate Transporter;Heroin;heroin use;Image;Imaging technology;Immobilization;improved;in vivo;Incidence;innovation;Intervention;Investigation;Label;Life;Marijuana Dependence;marijuana use;marijuana use disorder;Matrix Metalloproteinases;Measurement;Measures;Mediating;Modeling;Molecular;Morphology;neural circuit;neuroadaptation;neurobiological mechanism;Neurobiology;Neurologic;Neurons;novel;Nucleus Accumbens;Odors;Opioid;Outcome;Output;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;Post-Traumatic Stress Disorders;postsynaptic;pre-clinical research;presynaptic neurons;Process;protein expression;Proteins;Rat Transgene;Rattus;response;restraint stress;Rodent;Rodent Model;Self Administration;Series;Severities;Signal Transduction;Stimulus;Stress;Stress and Coping;Stressful Event;stressor;Substance Use Disorder;Symptoms;Synapses;Synaptic Cleft;Synaptic plasticity;Synaptic Transmission;synergism;Training;Transgenic Organisms;Treatment outcome;Veterans

PROJECT_TITLE: Neuroadaptation produced by acute PTSD-like stress create vulnerability for cannabis addiction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURA-N (01)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The coronavirus disease 2019 (COVID-19) pandemic has had a profound negative impact on population mental health in the United States, especially for marginalized populations such as sexual minorities (SMs). SMs with diverse sexual orientation, gender, and racial/ethnic identities may be differentially impacted due to unique structural vulnerabilities, although few studies have explored this. The goal of this project is thus to examine the intersectional distribution and upstream determinants of SM mental health disparities over the course of the COVID-19 pandemic using an unprecedented data source and advanced epidemiologic methods, with the goal of generating knowledge to inform mental health equity efforts for COVID-19 relief and beyond.

PI_NAMEs: BECCIA, ARIEL L (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Address;Affect;analytical method;Anxiety Disorders;career;Characteristics;cohort;County;COVID-19;COVID-19 disparity;COVID-19 morbidity;COVID-19 mortality;COVID-19 pandemic;Data;Data Sources;Death Rate;Depressive disorder;Development;Dimensions;Disparity;Distress;Eating Disorders;Economics;Environment;Epidemiologic Methods;Epidemiology;epidemiology study;ethnic identity;ethnic minority;Ethnic Origin;experience;Fellowship;Financial Hardship;Fright;Gender;gender minority group;Goals;Health;Health Disparities Research;health disparity;health equity;Heterosexuals;high risk;Individual;Individual National Research Service Award;Infection;innovation;Institution;interest;intersectionality;Intervention;Knowledge;Legal;lens;Life;Longitudinal cohort study;marginalization;marginalized population;Mental Depression;Mental Health;Mental health promotion;Mentors;Mentorship;Methodology;Methods;Minority;minority stress;Modeling;mortality;multidimensional data;multilevel analysis;National Institute on Minority Health and Health Disparities;novel;Nurses' Health Study;Outcome;pandemic disease;pandemic impact;pandemic stressor;Pattern;Personal Satisfaction;Policies;Population;population based;Positioning Attribute;Postdoctoral Fellow;pre-pandemic;Prevalence;Process;psychological distress;Psychopathology;Public Health;Race;racial minority;Reporting;Research;Research Personnel;Risk;Sex Orientation;Sexual and Gender Minorities;sexual minority;sexual minority group;sexual minority health;Shapes;skills;social;social epidemiology;Social Identification;social stigma;spatiotemporal;stay-at-home order;Strategic Planning;Stress;stressor;Subgroup;Symptoms;theories;Time;Training;transmission process;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Sexual Minority Mental Health During the COVID-19 Pandemic: An Intersectional, Social Epidemiologic Investigation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-A(20)]