ORG_CITY: HOUSTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative: Atrial fibrillation (AF), the most prevalent sustained cardiac arrhythmia in the human population, is associated with a high incidence of stroke leading to substantial disability, suffering, and enormous health care costs. Because AF prevalence increases with age, affecting approximately 5% of the human population over 65, the incidence of AF will increase and continue to be a large public burden. In this proposal, we will perform an in depth study of genes that are important in AF.

PI_NAMEs: MARTIN, JAMES F (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: 4q25;Ablation;Adult;Affect;Age;Age Years;Aging;Alzheimer's disease related dementia;Antioxidants;aorta constriction;Arrhythmia;Atrial Fibrillation;Binding;BMP10 gene;Cardiac;Cardiac Myocytes;care costs;Cells;Chromatin;Chromosomes;Clinical;Counseling;Data;Defect;Development;Diabetes Mellitus;Diagnostic tests;disability;Disease;early onset;Endothelial Cells;environmental stressor;experimental study;Familial atrial fibrillation;Family;Future;gain of function;Gene Expression;Genes;Genetic;Genetic Predisposition to Disease;Genetic Transcription;Genome;genome wide association study;genome-wide analysis;Goals;Grant;Health Care Costs;Health Expenditures;Heart;Heart Atrium;Heart failure;Heterozygote;Homeobox Genes;homeodomain;Homeostasis;Human;Human Chromosomes;Human Genetics;human genome sequencing;human old age (65+);Hypertension;Incidence;Inflammation;Inflammatory;Injury;insight;Knowledge;Left;Left atrial structure;Left ventricular structure;Link;loss of function;Mechanical Stress;Mechanics;Methods;model organism;Molecular;Morphogenesis;Morphology;Multiomic Data;multiple omics;Mus;Mutant Strains Mice;Myocardial Infarction;NF-kappa B;novel;novel therapeutic intervention;Nuclear;Nuclear Receptors;Paper;Pathway interactions;Patient Care;Patients;pharmacologic;Population;Predisposition;Prevalence;Public Health;Pulmonary veins;Reactive Oxygen Species;Recurrence;Regulatory Element;Reporting;Resources;response;response to injury;Role;Series;sham surgery;Signal Transduction;Single Nucleotide Polymorphism;single nucleus RNA-sequencing;Solid;Source;stressor;Stroke;stroke incidence;syntax;Testing;Tissues;transcription factor;Work

PROJECT_TITLE: Pitx2 in atrial fibrillation

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PI_NAMEs: JOHNSON, KEITH A. (contact)

PROJECT_TERMS: abeta deposition;aging brain;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyloid deposition;analytical tool;Archives;base;Brain;Brain imaging;Categories;Cerebellum;Clinical;cohort;Collaborations;Collection;computer science;computerized data processing;Consent;Corpus striatum structure;Data;data acquisition;Data Analyses;Data Collection;data repository;Data Set;data sharing;database query;Databases;Dedications;Deposition;Development;Ensure;experience;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Functional Magnetic Resonance Imaging;Hippocampus;Human Resources;Image;Image Analysis;image processing;Imaging Techniques;Individual;Inferior;Informatics;Inherited;innovation;interest;Magnetic Resonance Imaging;Measurement;Measures;Methods;Mission;neuroimaging;Neurology;novel strategies;Participant;Physics;Pittsburgh Compound-B;Positron-Emission Tomography;Price;Process;Program Research Project Grants;programs;Protocols documentation;Proxy;Psychology;Publishing;Radiology Specialty;Research;Research Personnel;Research Project Grants;Rest;Sampling;Sampling Studies;Schedule;serial imaging;Series;Specific qualifier value;standard measure;Standardization;Stream;Supervision;tau Proteins;Testing;Thick;Tissues;tool;Training;uptake;Visualization software;white matter;White Matter Hyperintensity;Work;β-amyloid burden

PROJECT_TITLE: Imaging Core (Core C)


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: AUGUSTA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is the most common neurodegenerative disorder, currently accounting for 60–80 % of dementia cases. This application aims at identifying the molecular bases underlying the effects of aging on AD-related neuropathology and cognitive deficits. We expect that the results will provide insights into therapeutic interventions targeting specific HDACs and tissue-selective therapy.

PI_NAMEs: LU, XIN-YUN  (contact);WEINTRAUB, NEAL L

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Acceleration;Accounting;Age;age effect;age related neurodegeneration;Aging;aging brain;aging process;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Amyloid deposition;APP-PS1;Automobile Driving;base;Binding;Brain;Brain region;Brain-Derived Neurotrophic Factor;candidate identification;Cells;Cerebral cortex;Cognition;Cognitive;Cognitive deficits;cognitive enhancement;cognitive function;Complex;Data;Dementia;Development;Disease Progression;Down-Regulation;Epigenetic Process;Exhibits;EZH2 gene;Functional disorder;Future;Genes;Glutamates;HDAC9 gene;Hippocampus;Histone Deacetylase;histone methyltransferase;Impaired cognition;Impairment;improved;insight;Knockout Mice;Learning;Link;Mediating;Mediator;Memory;Memory impairment;Memory Loss;Modification;Molecular;mouse model;Mus;myocyte-specific enhancer-binding-factor 2C;Nerve Degeneration;Nerve Growth Factors;Neurodegenerative Disorders;neuronal pentraxin;Neurons;neuropathology;Neuropeptides;neurotransmission;Neurotrophin 3;overexpression;pathological aging;Pathology;Peripheral;pharmacologic;Play;Polycomb;pre-clinical;Prefrontal Cortex;Process;promoter;Protein Isoforms;recruit;Reporting;Role;Synapses;Synaptic plasticity;tau Proteins;Testing;Therapeutic Intervention;Tissues;transcription factor;transcriptome sequencing;Wild Type Mouse;Zinc

PROJECT_TITLE: Neuronal HDAC9, Synaptic Plasticity and Alzheimer's Disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Rehabilitation;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Deep brain stimulation is an emerging treatment for individuals suffering from severe obsessive-compulsive disorder (OCD), which is a common and disabling neuropsychiatric condition. To prepare this treatment for broad dissemination, we must build the knowledge and tools to enhance the precision with which stimulation is applied to individual brains. This research constructs a connectomic atlas for deep brain stimulation in OCD using the association of brain pathways and optimal behavioral outcomes.

PI_NAMEs: CHOI, KI SUENG  (contact);FIGEE, MARTIJN

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Acute;Anatomy;Anterior;Atlases;Axon;behavior change;behavior test;Behavior Therapy;Behavioral;behavioral outcome;Brain;Brain Mapping;brain pathway;Brain Stem;Clinical;Complex;connectome;Data;Deep Brain Stimulation;Disabling;Disparate;effective therapy;Electrophysiology (science);Evoked Potentials;Fiber;improved;Individual;individual patient;Internal Capsule;Knowledge;Limb structure;Link;Location;magnetic resonance imaging/electroencephalography;Maps;Measures;Mediating;Methods;neuropsychiatric disorder;neuropsychiatry;novel;Obsessive-Compulsive Disorder;Operative Surgical Procedures;Outcome;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Physiologic pulse;Prevalence;Refractory;Research;response;Rewards;Specific qualifier value;Specificity;Structure;success;Task Performances;Techniques;Testing;Thalamic structure;Therapeutic;Time;tool;tractography;Travel;white matter;Work

PROJECT_TITLE: Connectomic Deep Brain Stimulation for Obsessive Compulsive Disorder

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: BLACKER, DEBORAH L. (contact)

PROJECT_TERMS: Address;aging brain;Alzheimer's Disease;Amyloid;analytical method;Biological Markers;Biometry;Brain;Brain Pathology;Clinical;Clinical Data;Clinical Trials;Clinical Trials Design;Cognitive;cognitive performance;Communities;Complex;Consultations;Custom;Data;data access;Data Adjustments;Data Analyses;data de-identification;Data Element;data integration;data integrity;data management;Data Security;Data Set;data sharing;Data Storage and Retrieval;Database Management Systems;Databases;Dementia;Derivation procedure;design;Development;digital assessment;Disease;Drops;Ensure;Epidemiologic Methods;Event;Evolution;flexibility;follow-up;formycin triphosphate;Future;Genetic;Growth;Image;imaging modality;Impaired cognition;improved;Information Systems;innovation;Intervention;Joints;Knowledge;longitudinal analysis;Measurement;Measures;Mediation;Methods;Modeling;Modernization;neuroimaging;Participant;Pathology;Population;pre-clinical;prevent;Prevention trial;Procedures;Process;programs;quality assurance;Quality Control;query optimization;Research Design;Risk;Sample Size;Sampling;Secure;Security;Selection Bias;simulation;Source;Statistical Data Interpretation;Statistical Methods;Statistical Models;study population;System;tau Proteins;Testing;Time;tool;Translations;unsupervised clustering;Work

PROJECT_TITLE: Analytic Core (Core D)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE Pancreatic ductal adenocarcinoma is exceedingly aggressive and refractory to conventional and targeted therapies, including those directed at mutant KRAS-signaling (hyperactivated in >90% of cases); but the underlying mechanisms that determine therapeutic response/resistance—including pancreatic cancer stem cells—are poorly understood, and effective strategies to overcome therapeutic resistance are unavailable. These studies will mechanistically explore the regulation of the novel pancreatic cancer stem cell driver, HNF1A, define a strategy for targeting HNF1A using BET-inhibitors and specific depletion of BRD4, and assess the efficacy BET-inhibitors/BRD4-ablation in overcoming HNF1A-mediated resistance to targeting KRAS-signaling and pancreatic cancer stem cells. The data generated from this proposal will identify a clinically viable strategy to target HNF1A-dependent pancreatic cancer stem cells, overcome resistance to KRAS-targeting strategies, and improve outcomes for patients with pancreatic ductal adenocarcinoma.

PI_NAMEs: ABEL, ETHAN VINCENT (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Ablation;Affect;Apoptosis;BCL2 gene;Biological Assay;Biology;Bromodomain;Bromodomains and extra-terminal domain inhibitor;cancer cell;Cancer Etiology;cancer stem cell;cancer type;Cell Cycle Progression;Cell Death;cell growth;Cell Line;Cell Proliferation;Cell Survival;Cells;Cessation of life;ChIP-seq;Clinic;Clinical;combinatorial;conventional therapy;Data;Drug resistance;Drug Targeting;effective therapy;efficacy evaluation;Epigenetic Process;Foundations;gastrointestinal;Genes;genetic approach;genetic manipulation;Genetic Transcription;Goals;Growth;Human;improved;improved outcome;In Vitro;in vivo;inhibitor;innovation;insight;knock-down;KRAS2 gene;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP Kinase Gene;Mediating;MEKs;mutant;Mutation;Nature;new therapeutic target;next generation;novel;Oncogenes;Oncogenic;Organoids;outcome prediction;overexpression;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathway interactions;patient derived xenograft model;patient stratification;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;preclinical efficacy;Process;programs;Proliferating;Promoter Regions;Property;Proteins;Reader;Refractory;Regulation;Reporter;Resistance;response;Role;Signal Transduction;stem cell function;Survival Rate;targeted treatment;Testing;Therapeutic;therapy resistant;transcription factor;transcriptome;transcriptome sequencing;Treatment Protocols;treatment response;tumor;tumorigenesis;tumorigenic;Work

PROJECT_TITLE: Targeting HNF1A-mediated therapeutic resistance in pancreatic ductal adenocarcinoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Endocrine Disruptors;Estrogen;Genetics;Human Genome;Mental Health;Neurosciences;Pediatric

ORG_CITY: ROCHESTER

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative This proposal seeks to understand how endocrine disrupting chemical (EDC) mixtures cause the brain and behavior to develop abnormally in a sex dependent fashion. Our previous research revealed that a curated EDC mixture, representative of maternal and infant exposures, targets the perinatal testosterone surge in male mice. The proposed research will define the epigenetic mechanisms of sex-dependent behavioral toxicity following androgen disruption.

PI_NAMEs: TERRY, MARISSA SOBOLEWSKI (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Adult;Androgen Receptor;Androgens;Animals;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;Basic Science;Behavior;Behavioral;Behavioral Assay;Binding;Birth;bisphenol A;Brain;cell type;cellular targeting;Central Nervous System;Chemical Actions;Chemical Exposure;Child;Corpus striatum structure;Cytosine;Data;demethylation;Development;Disease;DNA;DNA Methylation;DNA Modification Methylases;Dose;early childhood;early onset;Economics;Embryo;embryonic stem cell;Endocrine;Endocrine Disruptors;Epidemiology;Epigenetic Process;ESR1 gene;Etiology;Event;experience;experimental study;Exposure to;Female;Financial cost;Future;Gene Modified;Genes;Genetic Models;Genome;genome-wide;genotypic sex;Health protection;Heterogeneity;Human;hypothalamic pituitary gonadal axis;imprint;Impulsivity;Incidence;Individual;Infant;Investigation;Knowledge;life span;life time cost;Link;male;Measurable;Measures;Mediating;Methyltransferase;Molecular;Mouse Strains;Mus;Neonatal;nerve stem cell;nervous system development;neural;neurobehavioral disorder;Neurodevelopmental Disorder;Neurons;neurotoxicity;Newborn Infant;Pathway interactions;Pattern;perfluorooctanoic acid;Perinatal;Phenocopy;Phenotype;Polychlorinated Biphenyls;preference;Public Health;repetitive behavior;Reporting;Research;Research Personnel;Risk;Risk Assessment;Rodent;Role;Sampling;Sentinel;Series;Serum;sex;sex as a biological variable;Sex Differences;Sex Differentiation;Signal Transduction;social;Social Behavior;social communication;social deficits;System;Targeted Research;Techniques;Testing;Testosterone;Toxic effect;Translating;Ventral Striatum

PROJECT_TITLE: Endocrine Disrupting Chemicals and Male-biased Neurobehavioral Disorders

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: DALLAS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE A major goal of science is to understand mechanisms of basic cell development and differentiation processes in order to use such information to design strategies to prevent disease and improve the quality of human life. This application aims to address the question of how autophagy, a key cellular degradation system, degrades an amyloid-like protein to enable meiotic cell progression. This basic research aims to provide a rationale for developing new strategies to remove or prevent deleterious amyloid-like aggregation that is ubiquitously observed in aging neurons and to prevent chromosomal disorders such as Down syndrome.

PI_NAMEs: WANG, FEI  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Acute;Address;Aging;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Autophagocytosis;Basic Science;Binding;Biochemical;Biochemistry;Biological Models;Cell Death;Cell division;Cells;cellular imaging;Centrosome;Chromosome Segregation;Congenital chromosomal disease;Coupled;Cyclins;Cytokinesis;Defect;design;Development;Diploidy;Disease;Dissection;Down's Syndrome;Event;Feedback;Frequencies;Gametogenesis;Gene Expression;Genes;Genetic;Germ Cells;girls;Goals;Grant;Haploidy;Human;imaging approach;improved;inhibition of autophagy;Laboratories;Life;Link;Mass Spectrum Analysis;Maternal Messenger RNA;Mediating;Meiosis;Membrane;membrane biogenesis;Membrane Proteins;Messenger RNA;Molecular;monomer;multicatalytic endopeptidase complex;Mutagenesis;mutant;Nerve Degeneration;Neurons;Newborn Infant;novel;nuclear division;Pathway interactions;Personal Communication;Phenotype;Phosphorylation;Phosphotransferases;Play;posttranscriptional;premature;prevent;Prevention strategy;Process;Production;programs;Protein Dephosphorylation;Proteins;Proteolysis;Regulation;Reporting;Repression;restraint;ribosome profiling;RNA Binding;RNA-Binding Proteins;Role;Saccharomyces cerevisiae;Saccharomycetales;Science;segregation;Set protein;Sexual Reproduction;Sister Chromatid;SNAP receptor;spindle pole body;stem cells;Structure;Surface;System;Therapeutic;Translational Repression;Translations;Turner's Syndrome;Ubiquitin;Universities;Work;Yeasts

PROJECT_TITLE: Mechanistic dissection of a novel meiotic exit regulation by autophagy

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: ARNOLD, STEVEN E (contact)

PROJECT_TERMS: Age;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Automobile Driving;biobank;Biological;Biological Assay;Biological Markers;biomarker panel;Blood;Blood Banks;Blood Vessels;blood-based biomarker;brain health;cardiovascular risk factor;CCL2 gene;CCL4 gene;Cell Line;Cerebrospinal Fluid;Clinical;Cognition;cohort;Cohort Studies;Collaborations;Collection;Complement 1q;Complex;Data;Dementia;design;Diagnosis;DNA;Enzyme-Linked Immunosorbent Assay;experience;functional decline;Functional disorder;Grant;IL8 gene;Immune response;Immunoassay;Impaired cognition;Individual;Inflammation;Inflammatory;inflammatory marker;Injury;interest;Interferon Type II;Interleukin-1 beta;Interleukin-2;Interleukin-4;Interleukin-6;KDR gene;Laboratories;Light;Matrix Metalloproteinases;Measurement;Measures;Metabolic;Methods;MicroRNAs;Mission;Molecular;Monitor;Nerve Degeneration;neurofilament;neuroimaging;Neurology;neuron loss;neuropathology;Neurosciences;new technology;novel marker;Participant;Pathology;PGF gene;Pharmaceutical Preparations;Physical activity;Plasma;Positron-Emission Tomography;Prevention;Preventive treatment;Procedures;Process;Program Research Project Grants;Psychiatry;Recording of previous events;Research;Research Personnel;response to injury;RNA;Robotics;Sampling;Scientist;Seasons;Serum;single molecule;Site;Specificity;Symptoms;Synapses;tau Proteins;Technology;Testing;Time;TNF gene;treatment response;Vascular Cell Adhesion Molecule-1;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factor D;Vascular Endothelial Growth Factors;vascular injury;Whole Blood;Work

PROJECT_TITLE: Biomarkers Core (Core E)


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Skin Cancer

PHR: Narrative Our study examines the role of melanin pigments in melanoma susceptibility, based upon several recent discoveries: that the redhair background is associated with numerous “invisible” moles, that these moles have significantly elevated risk of melanoma transformation (spontaneously or after UV exposure), and that the Parkinson’s Disease drug L-Dopa further amplifies this melanoma risk by unexpectedly stimulating red pigment synthesis. These studies will employ a series of genetically engineered mouse models to dissect pathways of elevated melanoma risk and several strategies aimed at diminishing the melanoma risk, based on elucidation of the underlying mechanisms.

PI_NAMEs: FISHER, DAVID E (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Address;Anabolism;Antioxidants;biobank;Buffers;Candidate Disease Gene;carcinogenicity;Chemicals;Clinical;Clonality;Color;comparative;Complement;Darkness;Data;Development;Dopamine;Dose;Drops;Engineering;Enzymes;Etiology;eumelanin;Event;Exhibits;FDA approved;Fluorescence;Genes;Genetic;genetic pedigree;Genetic Transcription;Genetically Engineered Mouse;Glutathione;Hair;Hereditary Melanoma;Human;Incidence;Individual;Institution;Label;Lesion;Levodopa;Light;Link;loss of function;Malignant Neoplasms;Mediating;Melanins;melanocyte;Melanoma;melanomagenesis;Melanosomes;Minority;Mitochondria;Modeling;Mole the mammal;mouse model;Mus;Mutation;NADP;Natural regeneration;Nevi and Melanomas;Nevus;Oncogenes;Oxidation-Reduction;Oxidative Stress;Parkinson Disease;Pathway interactions;Patients;Peroxides;Persons;Pharmaceutical Preparations;Phase;pheomelanin;Pigmentation physiologic function;Pigments;Predisposition;Prevention strategy;Process;Production;programs;Publications;Publishing;repository;Risk;risk mitigation;Role;senescence;Series;Skin;small molecule;solar ultraviolet radiation;Sorting;Specimen;Sulfhydryl Compounds;Sunscreening Agents;Testing;Topical agent;transcriptomics;UV Radiation Exposure;UV sensitive;UVA induced;Variant;Visual

PROJECT_TITLE: MITF from control of pigmentation to melanoma risk

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prostate Cancer;Urologic Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Percutaneous needle placement plays a fundamental role in biopsy and focal ablation of prostate cancer. The goal of this project is to develop and disseminate free open-source software named OpenIGTLink to support advanced image-guided robot-assisted systems, where a robotic system guides a needle into the prostate based on biomechanical, data-driven, and hybrid models that predict the tissue and needle deformation in the patient during insertion. We expect that the accurate prediction will enable individualized planning and control for robot-assisted needle placement and improve accuracy biopsy and focal ablation.

PI_NAMEs: DIAZ-MERCADO, YANCY ;KRIEGER, AXEL ;LEONARD, SIMON ;TOKUDA, JUNICHI  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Ablation;Address;Anatomy;Animal Model;biomechanical model;Biomechanics;Biopsy;Brachytherapy;Characteristics;Clinical;Clinical Data;clinical practice;Communication;Compensation;Computer software;Core Biopsy;Data;data-driven model;Diagnosis;Dose;Elements;Ensure;Feedback;Generations;Goals;Hybrids;Image;image guided;image guided intervention;Imaging technology;improved;in vivo;in vivo Model;individual patient;Intervention;Lesion;Machine Learning;machine learning model;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Medical;Methods;Modeling;Names;Needle biopsy procedure;Needles;open source;Outcome;Pathologic;Patient Preferences;Patients;Physicians;Play;Population;Positioning Attribute;predictive modeling;Procedures;Process;prospective;Prostate;Prostate Ablation;prostate biopsy;Prostate Cancer therapy;real-time images;robot assistance;robot control;robotic system;Robotics;Role;simulation;software development;Structure of base of prostate;System;Systems Integration;Testing;Thermal Ablation Therapy;Tissue Model;Tissue Sample;Tissues;Training;tumor;United States;Update;Work

PROJECT_TITLE: OpenIGTLink: a network communication interface for closed-loop image-guided interventions

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Acceleration;Age;aging brain;Alzheimer's Disease;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Anatomy;Autopsy;behavioral outcome;Biological Assay;Biological Markers;Blood;Blood Vessels;Brain;Clinical;clinical phenotype;Clinical Trials;Cognitive;cohort;Complex;Corpus striatum structure;Data;Data Set;Deposition;Distant;Failure;follow-up;formycin triphosphate;Genotype;Goals;Heterogeneity;Image;Impaired cognition;improved;Inferior;Link;Location;longitudinal positron emission tomography;Measures;Mediating;neocortical;Network-based;neuropathology;Neuropsychology;novel;Outcome;Participant;Pathologic;Pathology;Physical activity;Pittsburgh Compound-B;Plasma;Population;Positron-Emission Tomography;pre-clinical;programs;Research;Risk;Sampling;serial imaging;sex;Structure of inferior temporal gyrus;synaptic function;systemic inflammatory response;tau aggregation;tau Proteins;Therapeutic;therapeutic target;Therapeutic Trials;Time

PROJECT_TITLE: Temporal sequence, anatomic progression, and interaction of amyloid-beta and tau (Project 1)


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative  This proposed research is expected to not only advance integrative post-GWAS data analysis and interpretation for more powerful identiﬁcation of novel target genes, brain regions and their functional connectivities, and other risk (and protective) factors that are putatively causal to Alzheimer's disease (AD), but also contribute valuable computational tools to the elucidation of genetic components and etiology of AD and other common diseases and complex traits, thus facilitating their prevention, early diagnosis and therapeutic development.

PI_NAMEs: PAN, WEI  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;biobank;Biological;Brain;Brain imaging;Brain region;causal variant;Clinical;Cohort Studies;Communities;Complex;Computer software;computerized tools;Data;Data Analyses;Data Set;Detection;Disease;Documentation;Early Diagnosis;Environment;epidemiology study;Etiology;flexibility;Gene Expression;Genes;Genetic;genetic variant;genome wide association study;Goals;Image;Incidence;Individual;insight;Intervention;Joints;Lasso;Least-Squares Analysis;Life Style;Linkage Disequilibrium;Maps;Mediating;Mendelian randomization;Methods;Modeling;Molecular;multiple datasets;novel;Observational epidemiology;Observational Study;Outcome;Phenotype;pleiotropism;Prevention;programs;protective factors;Public Domains;Relaxation;Research;response;Risk;Risk Factors;Role;Sampling;software development;Statistical Computing;Statistical Methods;statistics;Testing;theories;therapeutic development;Tissue-Specific Gene Expression;Tissues;trait;transcriptome;web site;Writing

PROJECT_TITLE: Discovering causal genes, brain regions and other risk factors for Alzheimer'a disease

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Lung;Lung Cancer;Prevention;Rare Diseases;Tobacco;Tobacco Smoke and Health

ORG_CITY: RICHMOND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: NARRATIVE. Lung cancer is a main cause of cancer deaths worldwide, and it is important to investigate the mechanisms of the pathogenesis of this disease. Cell cycle arrest and senescence serve as barriers to prevent the proliferation of the cells with damaged genomes. Here, we will determine whether the loss of DREAM complex can promote lung carcinogenesis caused by genotoxic stress or by activation of Ras pathway.

PI_NAMEs: LITOVCHICK, LARISA  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Address;Adenocarcinoma Cell;airway epithelium;Alleles;Animals;Binding;Breeding;Bypass;Cancer Etiology;cancer initiation;cdc Genes;CDKN2A gene;Cell Aging;Cell Cycle;Cell Cycle Arrest;Cell Cycle Progression;cell injury;Cell Proliferation;Cell Survival;Cells;Cessation of life;Chronic;Clinical Data;Communities;Complex;Copy Number Polymorphism;CRISPR/Cas technology;Data Analyses;Detection;detection of nutrient;Development;Diagnostic;Disease;DNA Damage;DNA Repair;DNA Repair Gene;driver mutation;Early Diagnosis;Environmental Risk Factor;Epithelial Cell Proliferation;Epithelial Cells;Experimental Models;Exposure to;Future;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;Genome;genome editing;Genotoxic Stress;genotoxicity;Growth;Growth Factor;Heterozygote;high reward;high risk;Histologic;Human;Human Cell Line;Immune;In Vitro;Inflammatory;Investigation;irradiation;Knock-in;Knowledge;KRAS2 gene;Lesion;Lung;Lung Adenocarcinoma;lung carcinogenesis;lung histology;Lung Neoplasms;lung tumorigenesis;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Mediating;Messenger RNA;Modeling;Molecular;Mouse Cell Line;mouse model;mRNA Expression;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;neoplastic;Non-Small-Cell Lung Carcinoma;novel;novel strategies;Oncogenic;Outcome;Pathogenesis;Pathway interactions;Phenotype;Phosphorylation;Phosphotransferases;Physiological;Play;premalignant;prevent;Prevention;Prevention strategy;Proliferating;Proliferation Marker;promoter;protein expression;Protein Family;Protein Kinase;Proteins;Radiation;Radiation induced damage;Radon;Recording of previous events;recruit;repaired;Repression;Repressor Proteins;Research;response;Retinoblastoma;Retinoblastoma Protein;Risk Factors;Role;senescence;Serine;Signal Transduction;small cell lung carcinoma;Smoker;Squamous cell carcinoma;Staging;survival outcome;targeted treatment;Testing;The Cancer Genome Atlas;tobacco exposure;Tobacco smoke;Tobacco smoking behavior;TP53 gene;Transcription Repressor;tumor;tumor progression;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis

PROJECT_TITLE: Role of the DREAM complex in the lung tumor suppression

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: CHHATWAL, JASMEER P (contact)

PROJECT_TERMS: Acceleration;actigraphy;Acute;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amino Acids;Amyloid;Biological;Biological Markers;biomarker panel;Blood Vessels;causal model;cerebral atrophy;Cerebrospinal Fluid;cerebrovascular;Clinical;Cognition;Cognitive;cognitive performance;Data;Development;Episodic memory;Etiology;executive function;follow-up;Funding;Hippocampus;Home;Image;imaging biomarker;immune activation;Immunoassay;Impaired cognition;Impairment;individual variation;Inflammation;Inflammatory;inflammatory marker;Injury;Interferon Type II;Interleukin-4;Intervention;late life;lifestyle factors;Light;Literature;Magnetic Resonance Imaging;Measurement;Measures;Medical History;Modeling;modifiable risk;molecular pathology;N-terminal;Nerve Degeneration;neurofilament;novel;older adult;Older Population;Participant;Pathologic;Pathology;Pathway interactions;Pattern;pedometer;Physical activity;Physical assessment;Plasma;Positron-Emission Tomography;Process;prospective;regional atrophy;Risk;Risk Factors;Role;secondary analysis;systemic inflammatory response;tau aggregation;tau Proteins;Variant;Vascular Diseases;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factors;vascular factor;vascular injury;wearable device;white matter;β-amyloid burden

PROJECT_TITLE: Vascular factors, physical activity, and inflammation as modulators of neurodegenerative and cognitive trajectories (Project 2)


NIH_SPENDING_CATS: Asthma;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Lung;Pediatric;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The University of Washington and the Duwamish River Community Coalition propose a randomized control trial that evaluates the effectiveness of low-cost box fans equipped with filters to reduce asthma symptoms among children and improve indoor air quality. This community engaged research project will also evaluate individual and community level empowerment and engagement as well as conduct a community-directed air pollution monitoring campaign to better characterize air quality in the Duwamish Valley.

PI_NAMEs: HAJAT, ANJUM  (contact);LOPEZ, PAULINA

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Address;Advocacy;Advocate;Air;air filter;air filtration;air monitoring;Air Movements;Air Pollution;air pollution control;Aircraft;ambient air pollution;Area;Asthma;Carbon Black;Carbon Dioxide;Child;Childhood Asthma;Cities;Color;Communities;community empowerment;community engaged research;community engagement;Community Health;Community Health Aides;cost;Coupled;Data;Death Rate;Decision Making;design;effectiveness evaluation;elementary school;Elements;empowerment;environmental disparity;Environmental Health;environmental health disparity;Environmental Pollution;Evaluation;experience;Face;Forced expiratory volume function;Goals;Government;Green space;Health;health assessment;health disparity;health equity;Heart Diseases;high efficiency particulate air filter;Home;Hospitalization;Household;Housing;improved;Individual;indoor air;Indoor Air Quality;indoor concentrations;Indoor environment;indoor particulate matter;Industrialization;Infrastructure;interest;Intervention;intervention cost;Leadership;Life Expectancy;Linguistics;lower income families;Measurement;Measures;member;Modeling;Molds;Monitor;Multilingualism;Neighborhoods;Nitrogen Dioxide;Outcome;Participant;Particulate;Particulate Matter;people of color;Phase;Policies;Policy Maker;Policy Making;pollutant;Pollution;poor health outcome;Price;primary outcome;Process;programs;Qualifying;Randomized, Controlled Trials;recruit;Regulation;remediation;Research;Research Project Grants;resilience;Resolution;response;Rest;Schools;secondary outcome;sensor;Severities;Source;superfund site;Symptoms;System;Testing;tool;traffic-related air pollution;Training;Training and Education;Transportation;Universities;Washington;Youth

PROJECT_TITLE: Action towards health equity and improved air quality in the Duwamish Valley: A multilevel asthma intervention


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: Persons with COPD benefit from being physically active, but they are often limited by chronic musculoskeletal pain. This project will determine whether a non-pharmacologic, integrated, technology- mediated walking and Tai Chi mindfulness intervention can improve physical function in Veterans with COPD and chronic musculoskeletal pain. The proposed research addresses VA Rehabilitation R&D Service's high priority area of improving health-related quality of life by reducing disease burden and maximizing function in Veterans with chronic disease.

PI_NAMEs: MOY, MARILYN L. (contact)

PROJECT_TERMS: Achievement;Activities of Daily Living;Acute;Address;Aerobic;Affective;Aging;Anxiety;Area;Behavioral;biopsychosocial;burden of illness;Cause of Death;Cessation of life;Chronic Disease;chronic musculoskeletal pain;Chronic Obstructive Pulmonary Disease;chronic pain;chronic pain management;Cognitive;comparison control;Complex;conditioned fear;Coping Skills;Couples;Coupling;debilitating symptom;deconditioning;Disease;Distress;Dyspnea;Education;efficacy evaluation;Emotional;Enrollment;Exercise;exercise intervention;experience;Extinction;Feedback;functional disability;Funding;Goals;Guidelines;health related quality of life;High Prevalence;Home;Hospitalization;improved;Informal Social Control;innovation;Instruction;instructor;Internet;Intervention;Knowledge;Libraries;Long-Term Effects;Lower Extremity;Measures;Mediating;Medical;Mental Depression;mindfulness;mindfulness intervention;Modality;Monitor;Morbidity - disease rate;mortality;Motivation;Movement;multimodality;Musculoskeletal;National Center for Complementary and Integrative Health;neuromuscular function;neurophysiology;Nociception;Nonpharmacologic Therapy;Older Population;online community;Online Systems;Outcome;Outcome Assessment;Pain;pain catastrophizing;Pain intensity;Pain interference;Pain management;pain reduction;Participant;Patient-Focused Outcomes;Patients;pedometer;Persons;Physical activity;physical conditioning;Physical Function;physical inactivity;primary outcome;Process;Proprioception;psychologic;pulmonary function;Randomized;Randomized, Controlled Trials;Recommendation;rehabilitation strategy;Rehabilitation therapy;Research;research and development;Risk;Safety;secondary analysis;secondary outcome;Self Efficacy;Self Management;Services;Severities;Shortness of Breath;sleep quality;Social support;stress reduction;Symptoms;Tai Ji;Technology;Teleconferences;theories;treatment as usual;United States;Veterans;Veterans Health Administration;videoconference;Walking;web site;web-based intervention

PROJECT_TITLE: The Effect of a Technology-Mediated Integrated Walking and Tai Chi Intervention on Physical Function in Veterans with COPD and Chronic Musculoskeletal Pain

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CHICAGO

ORG_NAME: JESSE BROWN VA MEDICAL CENTER

ORG_STATE: IL

PHR: Significant resources have been devoted to the immediate rehabilitation needs of persons undergoing lower- limb amputation, but there needs to be greater consideration for the early identification and modification of potential risk factors responsible for long-term development of secondary health conditions such as low back pain. Prosthesis users are known to walk with distinct asymmetries, which may relate to prosthesis design and fitting procedures. Poor trunk posture and abnormal pelvic motions may be implicated in the development and persistence of low back pain in some unilateral, transfemoral prosthesis users. The purpose of this study is to investigate and compare the effects of two prosthetic socket designs on the trunk posture and pelvic motions of transfemoral prosthesis users to determine if current sockets and prosthetic fitting procedures may contribute to the risk of development of low back pain. This work is directly applicable to the Veteran Health Administration’s Patient Care Mission because the results may improve the gait and quality of life of Veterans.

PI_NAMEs: STINE, REBECCA  (contact)

PROJECT_TERMS: absorption;Adopted;Amputation;Amputees;Anterior;Back;bone;Compensation;Comprehension;Containment;Control Groups;Data;Development;Early identification;Equilibrium;Etiology;Exhibits;Femur;Future;Gait;Health;Immobilization;improved;Investigation;Joints;kinematics;Knee;Knee Prosthesis;Knowledge;Lead;Leg;limb amputation;Limb Prosthesis;Lordosis;Low Back Pain;Lower Extremity;Measures;Methods;Mission;Modeling;Modification;Motion;Musculoskeletal;neglect;Patient Care;Pattern;Pelvis;Persons;Phase;Play;Population;Positioning Attribute;Posture;prevent;Procedures;Process;Prosthesis;Prosthesis Design;prosthesis fitting;prosthesis wearer;prosthetic alignment;prosthetic socket;Quality of life;Rehabilitation therapy;Research;research and development;Research Subjects;residual limb;Resources;Risk;Risk Factors;Role;Rotation;Shock;socket design;sound;Spinal;Therapeutic Intervention;therapy design;therapy development;Vertebral column;Veterans;Veterans Health Administration;Walking;walking speed;Work

PROJECT_TITLE: Does Transfemoral Prosthetic Socket Design and Alignment Influence Low Back Pain? A Comparison Between Ischial-Containment and Sub-Ischial Sockets

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Kidney Disease;Precision Medicine

ORG_CITY: IOWA CITY

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative  The over-arching goals of this research proposal focused on C3 Glomerulopathy are to study the role of genetic variation in driving disease, to define the underlying characteristics of autoantibodies identified in C3G patients by epitope mapping, and to develop and clinically validate predictive models of disease outcome based on a longitudinal study of the natural history of C3G that includes analysis of clinical, genetic, complement and biopsy data. Completing these goals will provide a better understanding of C3G and improve care for C3G patients.

PI_NAMEs: BREHENY, PATRICK ;NESTER, CARLA M;SMITH, RICHARD J.H. (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: acquired factor;Address;Affinity;Age;Alternative Complement Pathway;Autoantibodies;Autoantibody binding;Automobile Driving;Binding;Biopsy;Caring;Characteristics;Classification;Clinical;clinical care;cohort;Complement;Complement 3 Convertase;Complement Factor H;Complement Membrane Attack Complex;Complex;Data;Deposition;Development;Disease;disease natural history;Disease Outcome;disorder subtype;effective therapy;End stage renal failure;enzyme pathway;Epitope Mapping;Epitopes;Face;Foundations;Functional disorder;fusion gene;gain of function mutation;gene complementation;Genes;Genetic;genetic variant;Genetic Variation;glomerular basement membrane;Glomerulonephritis;Glycocalyx;Goals;Grant;Half-Life;Heparan Sulfate Proteoglycan;high risk;improved;Injury to Kidney;insight;Kidney;kidney biopsy;Kidney Diseases;Kidney Failure;Knowledge;Longitudinal Studies;Medical;Modeling;Natural History;novel;Outcome;Pathogenesis;Pathologic;Pathway interactions;Patients;Pattern;permissiveness;personalized medicine;Pilot Projects;post-transplant;predict clinical outcome;predictive modeling;Prognosis;Prognostic Factor;prognostic value;Proteins;Recurrent disease;Renal glomerular disease;Research Proposals;Role;Serum;Site;Specificity;Subgroup;Transplantation;treatment response

PROJECT_TITLE: C3 Glomerulopathy -- A Collaborative Study

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: SCHULTZ, AARON P (contact)

PROJECT_TERMS: actigraphy;Age;age effect;Age related pathologies;aged;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;AMPA Receptors;Amyloid;Amyloid beta-Protein;Blood flow;Brain;Brain imaging;cardiovascular risk factor;Cerebrovascular Circulation;Cognition;Cognitive;cohort;Data;Dementia;Development;Disease;effective intervention;effective therapy;Evaluation;Excision;Exhibits;expectation;Face;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;formycin triphosphate;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;genetic regulatory protein;Goals;Grant;Health;high reward;high risk;Hippocampus;Image;imaging capabilities;imaging modality;Impaired cognition;improved;innovation;Investigation;Kinetics;Link;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Metabolic;molecular pathology;multimodal neuroimaging;multimodality;Names;neural network;Neurons;novel;Outcome;Participant;Pathologic;Pathology;Pattern;pedometer;Physical activity;Positron-Emission Tomography;Predisposition;preservation;Property;Proteins;Proxy;radioligand;Receptor Signaling;Regulation;resilience;Resources;Rest;Risk;Rotation;Scanning;Signal Transduction;Source;Synapses;synaptic function;System;tau Proteins;tau-1;Testing;Time;Tracer;Visual;Work

PROJECT_TITLE: Multimodal neuroimaging assessments of synaptic integrity: Linking pathology and cognition (Project 3)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Ataxia Telangiectasia;Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Pediatric;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: There are no known cures for neurodegeneration—the progressive loss of neurons that can occur sporadically in the human population with age and also in patients with specific genetic mutations. Here we use early-onset, familial cerebellar neurodegeneration as a model to understand the molecular events that occur early in the progression of disease. We hypothesize that unrepaired breaks in DNA are a key component of this progression and use human neurons in culture as well as biochemistry-based approaches to characterize the origin and consequences of this DNA damage.

PI_NAMEs: PAULL, TANYA T (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Active Sites;Adolescence;Affect;Age;Alleles;Amyloid Fibrils;Ataxia;Ataxia Telangiectasia;ataxia telangiectasia mutated protein;Ataxia Telangiectasia Patients;ataxia-telangiectasia like disorder;ATM deficient;ATM function;Automobile Driving;Base Excision Repairs;Biochemistry;biological adaptation to stress;Brain;brain tissue;Cell Cycle Arrest;Cell Line;Cell model;cell type;Cells;Cerebellar Ataxia;Cerebellum;Childhood;Clinical;Complex;Cytosine;Defect;Detergents;differentiation in vitro;Disease;Disease Progression;DNA;DNA Damage;DNA Double Strand Break;DNA metabolism;DNA Repair;DNA Sequence Alteration;DNA Single Strand Break;early onset;Enzymes;Event;Exhibits;experimental study;Genes;Genetic Transcription;genome-wide;Genomic DNA;Genomic Instability;Health;Human;human disease;Hybrids;In Vitro;Label;Lesion;Location;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Methylation;Modeling;Molecular;motor control;mutant;Mutation;Nerve Degeneration;Neurologic Dysfunctions;neuron loss;Neuronal Differentiation;Neurons;novel;Nucleotide Excision Repair;oxidation;oxidative damage;Oxidative Stress;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Phosphorylation;Phosphotransferases;Play;Poly Adenosine Diphosphate Ribose;Poly(ADP-ribose) Polymerases;polymerization;Polymers;polypeptide;Population;progressive neurodegeneration;protein aggregation;protein purification;Proteins;proteostasis;rare variant;Recombinant Proteins;Regulation;Resistance;response;RNA;Role;Signal Transduction;Single Strand Break Repair;Site;Source;Stress;Syndrome;Testing;Tissue Sample;tumor progression;Work

PROJECT_TITLE: Origins of DNA damage driving pathology in human neurodegeneration

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

PHR: NARRATIVE – OVERALL Viruses that affect the respiratory system are the most common global illness and can have significant medical consequences for people with chronic inflammatory diseases. In this project, we will study immune responses in the airway and blood to these viruses in both adults with rheumatoid arthritis and children with asthma, allergies and obesity. We will use multiple –omics approaches to determine how immune response to respiratory viruses differs in these vulnerable populations and examine how that affects the severity of their viral illness and chronic inflammatory conditions.

PI_NAMEs: ALTMAN, MATTHEW C.;MIKACENIC, CARMEN R (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Acceleration;Acute;Adenoviruses;Adult;Affect;Age;Antibodies;Antigens;Asthma;Atlases;atopy;Autoimmune Diseases;benefit sharing;Biological Assay;Biology;Blood;Blood specimen;Cells;Characteristics;Child;Childhood;Chronic;Chronic Disease;chronic inflammatory disease;Clinical;clinical risk;cohort;comorbidity;Coronavirus;COVID-19 pandemic;Cytometry;Data;Data Analyses;data integration;Disease;Economics;Epidemic;Epithelium;Ethnic Origin;Etiology;experience;Family;Flow Cytometry;Frequencies;Funding;Future;Generations;Genetic;Genomics;Goals;high dimensionality;Human;human disease;Hypersensitivity;Immune;Immune response;Immune System Diseases;Immunology;Immunophenotyping;Immunosuppression;in silico;Individual;Infection;infection risk;Inflammatory;influenzavirus;insight;Intervention;Kinetics;Lead;mathematical model;Measurement;Medical;Meta-Analysis;Metapneumovirus;Methods;Methylation;methylome;Modeling;Molecular;Morbidity - disease rate;mortality;Mucositis;Mucous Membrane;multidimensional data;Multiomic Data;multiple omics;novel;novel therapeutics;Obesity;Outcome;parainfluenza virus;pathogen;Pathogenesis;Patients;Pediatric cohort;Persons;Phenotype;predict clinical outcome;programs;proteogenomics;Proteome;Race;Research;respiratory infection virus;Respiratory Mucosa;Respiratory syncytial virus;Respiratory System;Respiratory Tract Infections;respiratory virus;response;Rheumatoid Arthritis;Rhinovirus;Risk;sample collection;Sampling;SARS-CoV-2 immune response;Severities;Severity of illness;Socioeconomic Status;spatiotemporal;Stimulus;System;Systems Biology;Therapeutic;therapeutically effective;transcriptome;transmission process;treatment strategy;United States National Institutes of Health;Vaccines;Viral;Viral Respiratory Tract Infection;Virus;Virus Diseases;virus host interaction;Vulnerable Populations

PROJECT_TITLE: Systems Immunology profiling of respiratory viral infections in vulnerable populations


NIH_SPENDING_CATS: Infectious Diseases

PI_NAMEs: MIKACENIC, CARMEN R (contact)

PROJECT_TERMS: Accountability;Administrative Personnel;Clinical;Communication;Communities;Contracts;Data Analyses;data management;design;Ensure;Expenditure;experience;Funding;General Population;Genomics;Goals;Grant;Guidelines;Immunology;Institutional Policy;Lead;Leadership;Manuscripts;meetings;Monitor;National Institute of Allergy and Infectious Disease;operation;Phenotype;Preparation;programs;Regulation;Research;Research Project Grants;Resource Allocation;System;Training;United States National Institutes of Health;Viral Respiratory Tract Infection;Vulnerable Populations

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Neurosciences;Regenerative Medicine

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Public health relevance Damage to the nervous system often leads to persistent deficits due to failure of neurons to regrow their axons after nervous system lesion. Axon regeneration is governed by close interactions between extrinsic glial environment and intrinsic growth ability. Investigating how glial control of axon regeneration is of therapeutical significance. In the current proposal, we propose to investigate the cellular and signaling mechanisms by which glial cells control neuronal type- specific axon regeneration in Drosophila, a genetic model organism that shares conserved axon regeneration mechanisms with mammals.

PI_NAMEs: XIANG, YANG  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: 5'-Nucleotidase;Adenosine;Afferent Neurons;Anatomy;ATP Receptors;Axon;axon injury;axon regeneration;Axotomy;Cell Communication;Cells;Coupled;Cues;Data;design;Drosophila genus;Engineering;Environment;Environmental Risk Factor;Event;Exhibits;Exocytosis;extracellular;Failure;Family;Genetic;Genetic Models;Goals;Growth;in vivo;in vivo Model;Injury;injury and repair;interdisciplinary approach;Investigation;Label;Larva;Lesion;Mammals;Measures;Membrane Proteins;Metabolic;Metabolism;model organism;Modeling;Molecular;mutant;Natural regeneration;Nervous System;Nervous System Trauma;Neuroglia;neuronal excitability;Neuronal Injury;Neurons;neurotransmission;Nociception;novel;Nucleotidases;Pilot Projects;Process;programs;public health relevance;Purinergic P1 Receptors;real-time images;receptor;receptor expression;Recovery of Function;regenerative;Resolution;response;response to injury;RNA Interference;Role;sensor;Signal Transduction;Source;spatiotemporal;Specific qualifier value;Testing;Therapeutic;Tissues;tool;Touch sensation

PROJECT_TITLE: Cellular and Molecular Mechanisms Underlying Neuronal Type-specific Axon Regeneration

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Arthritis;Asthma;Clinical Research;Infectious Diseases;Lung;Patient Safety;Pediatric

PI_NAMEs: BUCKNER, JANE HOYT (contact)

PROJECT_TERMS: Acute;Adult;Allergic;Asthma;Autoimmune Diseases;Bioinformatics;Biological;Child;Childhood Asthma;Clinic Visits;Clinical;Clinical Data;Clinical Protocols;Clinical Research;cohort;Consent Forms;Data Analyses;Data Collection;data management;Data Set;Databases;Ensure;Family history of;Genomics;Home;human subject protection;Human Subject Research;Immunology;Infrastructure;Inpatients;Institutional Review Boards;Intervention;Laboratories;Link;Longitudinal cohort;nasal swab;Patient Recruitments;patient responsibilities;Pediatric cohort;peripheral blood;Phenotype;Policies;programs;Protocols documentation;Recording of previous events;recruit;Registries;repository;Research;Research Institute;Research Personnel;Research Project Grants;Rheumatoid Arthritis;Role;Sampling;Scientist;Specimen;Sputum;System;Translational Research;United States National Institutes of Health;urban setting;Viral Respiratory Tract Infection;Virginia;Vulnerable Populations

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: SPERLING, REISA A. (contact)

PROJECT_TERMS: abeta accumulation;Acceleration;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Anxiety;apolipoprotein E-4;Artificial Intelligence;Behavior;Behavioral;Blood Vessels;Brain;Clinical;Clinical Trials;clinically relevant;Cognitive;Cognitive aging;cognitive change;cognitive function;cognitive process;cognitive testing;cohort;Computer software;Data;digital;digital technology;Disease Marker;Early Diagnosis;Executive Dysfunction;Exposure to;Face;Failure;follow-up;formycin triphosphate;functional decline;Future;Genetic;Goals;Heterogeneity;Home;Image;Impaired cognition;Impairment;improved;indexing;Individual;Learning;Life;Life Experience;Link;Loneliness;Measures;memory retention;Mental Depression;mild cognitive impairment;Modality;Modeling;molecular pathology;Multimodal Imaging;Names;neocortical;Nerve Degeneration;neurobehavioral;Neuropsychology;novel;Older Population;Outcome;paired stimuli;Participant;Pathology;Patient Self-Report;Pattern;Performance;Phase;Positron-Emission Tomography;pre-clinical;prevent;Prevention trial;Process;protective factors;Reaction Time;Reporting;resilience;Risk;Series;sex;Signal Transduction;social engagement;Specificity;tau aggregation;tau Proteins;Testing;Time;Woman;Work

PROJECT_TITLE: Detection of early cognitive change: Linking to clinically meaningful outcomes (Project 4)


PI_NAMEs: LINSLEY, PETER S (contact)

PROJECT_TERMS: Acute;Adult;Allergens;Antibodies;antigen-specific T cells;Antigens;Autoantigens;B-Cell Antigen Receptor;Blood;Blood Cells;Blood specimen;Cell Separation;Cell surface;Cells;Child;Chromium;Chronic Disease;Clinical;Collection;Data;Data Analyses;data management;DNA;Gene Expression;genome-wide;Genomics;Genotype;Human;Immune;Immunology;Immunophenotyping;Individual;Link;Measurement;Measures;Methylation;next generation sequencing;Nose;Pathogenesis;Phenotype;Population;Process;proteogenomics;Protocols documentation;reconstruction;reference genome;Research Project Grants;respiratory infection virus;Rheumatoid Arthritis;RNA;Sampling;single-cell RNA sequencing;Specific qualifier value;Sputum;Stains;System;T-Cell Receptor;T-Lymphocyte;transcriptome;transcriptome sequencing;transcriptomics;Viral;Viral Respiratory Tract Infection;Vulnerable Populations;Work


NIH_SPENDING_CATS: Infectious Diseases;Lung

PI_NAMEs: WAMBRE, ERIK  (contact)

PROJECT_TERMS: Acute;adaptive immune response;Allergens;Antibodies;antigen-specific T cells;Antigens;autoreactive T cell;B-Lymphocytes;Bar Codes;Biological Assay;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Clinical;Collaborations;Data;Data Analyses;data management;effector T cell;Eragrostis;experimental study;Flow Cytometry;high dimensionality;Immune;Immune response;Immunology;Immunophenotyping;Innate Immune Response;Laboratories;Lymphoid Cell;Methods;monocyte;Myeloid Cells;Natural Killer Cells;Nose;novel;Pathogenesis;peripheral blood;Phenotype;Play;Population;Procedures;Protocols documentation;Regulatory T-Lymphocyte;Research Project Grants;respiratory infection virus;respiratory virus;response;Rheumatoid Arthritis;Role;Sampling;Side;Sputum;Standardization;System;T cell response;T-Lymphocyte;Viral Respiratory Tract Infection;Vulnerable Populations;Work;γδ T cells

PROJECT_TITLE: HIPC U19 Adaptive Immunophenotyping Core


NIH_SPENDING_CATS: Childhood Obesity;Genetics;Human Genome;Infectious Diseases;Lung;Obesity;Pediatric

PI_NAMEs: ALTMAN, MATTHEW C. (contact)

PROJECT_TERMS: Acute;acute infection;adaptive immune response;Adult;airway immune response;Allergens;Allergic;Antibodies;Antigens;Asthma;atopy;B-Cell Antigen Receptor;B-cell receptor repertoire sequencing;Blood specimen;CD8-Positive T-Lymphocytes;Cells;Child;Childhood;Chronic Disease;chronic respiratory disease;Clinical;clinical phenotype;comorbidity;comparison control;Cytometry;Data;Data Analyses;data integration;demographics;Disease;disorder prevention;DNA Methylation;experience;Frequencies;Future;Gene Expression;Generations;Genetic;Genomics;Genotype;Goals;high dimensionality;human disease;Hypersensitivity;IgE;Immune;Immune response;Immunity;Immunologic Memory;Immunology;Immunophenotyping;Infection;Inflammatory;Innate Immune Response;insight;Intervention Studies;Kinetics;Lead;Ligands;Link;Lymphocyte;Measures;Membrane Proteins;Methods;Molecular;molecular phenotype;Morbidity - disease rate;mortality;Mucous Membrane;multiple omics;Nasal turbinate bone structure;Nature;Nose;novel;Obesity;Outcome;Pathogenesis;Pathway interactions;Pattern;peripheral blood;Phenotype;Population;Populations at Risk;programs;proteogenomics;Proteome;pulmonary function;Receptor Cell;Reporting;Research;Resolution;respiratory;respiratory infection virus;respiratory virus;response;sample collection;Sampling;Seasons;Severities;Severity of illness;single-cell RNA sequencing;Source;spatiotemporal;Sputum;Standardization;Swab;Symptoms;System;Systems Biology;T-Lymphocyte;Time;Training;transcriptome;Viral;Viral Respiratory Tract Infection;Virus;Vulnerable Populations

PROJECT_TITLE: HIPC U19 Project 1


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative We are testing the hypothesis that the brain-gut-retina communicate through the regulation of immune cell function and that in diabetic retinopathy this communication is disturbed. Specifically, diabetes induces loss of expression of key neurotransmitters (somatostatin) in special centers in the brain and this loss of somatostatin results in the intestine, an immune tissue, becoming hyperstimulated. We postulate that this hyperstimulation results in the intestine generating pathological cells that leave the intestine, enter the circulation and go to the retina where they accelerate the development of diabetic retinopathy.

PI_NAMEs: DE LARTIGUE, GUILLAUME FH;FRAZIER, CHARLES J;GRANT, MARIA BARTOLOMEO (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Ablation;Acceleration;Adaptive Immune System;adenovirus mediated delivery;Adrenergic Receptor;Anatomy;Animals;Area;Bacterial Infections;Blood capillaries;Brain;CD8-Positive T-Lymphocytes;cell motility;Cell Physiology;Cell secretion;Cells;Characteristics;Circadian Rhythms;Circulation;Communication;comparison control;Cre lox recombination system;cytokine;Cytomegalovirus;cytotoxic;Data;Dependovirus;designer receptors exclusively activated by designer drugs;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Retinopathy;Diphtheria Toxin;Disease;dysbiosis;Electrophysiology (science);Enteral;Environmental Risk Factor;Excision;Flow Cytometry;Functional disorder;gain of function;Genetic;gut microbiome;Health;Homeostasis;Host Defense;Hyperactivity;Hypothalamic dysfunction;Hypothalamic structure;IL17 gene;Immune;immune function;immunoregulation;Impairment;Inflammation;Inflammatory;Injections;Injury;Innate Immune System;Insulin-Dependent Diabetes Mellitus;intestinal barrier;Intestines;loss of function;Mediating;microbiota;microorganism antigen;migration;Modeling;monocyte;Mus;Mycoses;Nerve;Neurons;Neurotransmitters;non-diabetic;novel strategies;Octreotide;optogenetics;Output;paraventricular nucleus;Pathogenesis;Pathogenicity;Pathologic;peripheral blood;pharmacologic;Phenotype;Plasma;Population;preservation;prevent;programs;Property;Publishing;recruit;Regulatory T-Lymphocyte;Reporter;response;Retina;Role;Serum;Signal Transduction;single-cell RNA sequencing;Site;small hairpin RNA;Somatostatin;somatostatin analog;Streptozocin;Synapses;System;T-Lymphocyte;T-Lymphocyte Subsets;Testing;tissue injury;Tissues;tool;trafficking;transcriptome sequencing;Viral

PROJECT_TITLE: Brain-gut-retina axis in diabetic retinopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: We will examine whether a combination of blood-based measures that reflect three different aspects of Alzheimer disease (AD) pathology better predict current or future AD symptoms than amyloid PET, a gold standard for AD brain pathology. If a blood test can provide better diagnostic information than more logistically complex tests, this could accelerate efforts to find drugs that prevent AD symptoms.

PI_NAMEs: SCHINDLER, SUZANNE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Acceleration;accurate diagnosis;Age;Alzheimer disease detection;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease therapy;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;associated symptom;Autopsy;Biological Assay;Biological Markers;Blood;Blood Plasma Volume;Blood specimen;Blood Tests;blood-based biomarker;Brain;Brain Pathology;brain volume;Cerebrospinal Fluid;Characteristics;Clinic;Clinical;clinical practice;Clinical Trials;Cognitive;cognitive testing;cohort;comorbidity;Complex;cost;Data;Dementia;Deposition;Development;Diagnosis;Diagnostic;Education;effective therapy;Enrollment;Frequencies;Functional disorder;Future;Genetic Markers;Genotype;Health;Image;imaging biomarker;Immunoprecipitation;Impaired cognition;improved;Individual;Light;Magnetic Resonance Imaging;Mass Spectrum Analysis;Measurement;Measures;Medical;Methods;mild cognitive impairment;Modality;Nerve Degeneration;Neurobehavioral Manifestations;neurofibrillary tangle formation;neurofilament;Non-linear Models;Older Population;Outcome;Patients;Performance;Pharmaceutical Preparations;Phenotype;Physicians;Plasma;polygenic risk score;Positron-Emission Tomography;precision medicine;prevent;Prevention trial;Protein Isoforms;Proteins;Proteomics;Race;rate of change;Recording of previous events;Reporting;Research;Research Personnel;Risk Estimate;risk prediction;risk stratification;Sampling;Senile Plaques;sex;Speed;Staging;Sum;Symptoms;tau Proteins;tau-1;Testing

PROJECT_TITLE: Staging Alzheimer disease with blood-based biomarkers


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Genetics;Human Genome;Infectious Diseases;Lung;Rheumatoid Arthritis

PROJECT_TERMS: Acute;acute infection;adaptive immune response;Address;Adult;Affect;Anti-citrullinated peptide antibody;Antibodies;Antibody Formation;Antigens;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;autoreactivity;B-cell receptor repertoire sequencing;B-Lymphocytes;Blood specimen;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Chronic;Clinical;Cytometry;Data;Data Analyses;Detection;Development;Disease;Disease Progression;Enrollment;Epithelium;extracellular;Extracellular Matrix;Frequencies;General Population;Generations;Genetic;Genomics;Goals;Health Expenditures;high dimensionality;Immune;Immune response;Immunoglobulin A;Immunologic Factors;Immunology;Immunophenotyping;Immunosuppression;Individual;Infection;infection risk;Inflammation;insight;Investigation;Kinetics;Lung;Measures;Membrane Proteins;Methods;Methylation;methylome;Molecular;Morbidity - disease rate;mortality;Mucosal Immune Responses;Mucositis;Mucous Membrane;Multiomic Data;multiple omics;nasal swab;neutrophil;Nose;novel;Outcome;Parainfluenza;Pathogenesis;Pathway interactions;Patients;Peptides;peripheral blood;Phenotype;Population;programs;proteogenomics;Proteome;pulmonary function;Research Project Grants;Resolution;respiratory;Respiratory Disease;Respiratory Mucosa;Respiratory Tract Infections;respiratory virus;response;Rheumatoid Arthritis;Rhinovirus;Risk;sample collection;Sampling;Seasons;Severities;Severity of illness;single-cell RNA sequencing;spatiotemporal;Specificity;Sputum;Standardization;System;systemic autoimmune disease;systemic autoimmunity;Systemic disease;systemic inflammatory response;T-Lymphocyte;Tenascin;Testing;Time;Tissues;transcriptome;Vimentin;Viral;Viral Respiratory Tract Infection;Virus;Vulnerable Populations


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: The goal of this research project is to address the NIH and NIA's grand challenge of using a person's own vehicle as a passive-detection system for flagging potential age- and/or disease-related aberrant driving behaviors that may signal early warning signs of functional decline of Alzheimer's disease (AD), even before standard clinical tests do so. Our Specific Aims will assess and combine key factors affecting driver behavior and clinical status in aging, mild cognitive impairment (MCI), and Alzheimer's clinical syndrome (ACS) as markers and moderators of risk: SA 1) Extract key real-world driver behavior features over a 3-month continuous, baseline period that classify NIA-AA core clinical criteria of MCI and ACS in drivers who are normally aging (N = 60), MCI (N = 80), or ACS (N = 40); SA2) Determine the extent to which real-world driver sleep and mobility mediate the relationship between extracted driver behavior and clinical features; SA3) Develop models (statistical and supervised machine learning) that combine features of driver behavior (from SA 1) and driver sleep and mobility (from SA2) to detect early signs of MCI and AD and predict disease progression. By building on our extensive successes in the current phase, the project directly advances NIH and NIA goals lo detect early warnings signs of decline and incipient AD-with the goal of screening, identifying, and tracking individuals at risk for AD from passive-monitoring of real-world behavior to predict clinical status and progression-promoting early treatment of AD and the next stage of interventions to prevent the progression of AD even in its preclinical stages.

PI_NAMEs: RIZZO, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Achievement;Activities of Daily Living;Address;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease risk;analytical method;analytical tool;Automobile Driving;Behavior;Biological;Biometry;Black Box;Caring;Classification;Clinical;clinical predictors;Cognitive;cognitive neuroscience;Communities;Computer Vision Systems;cost;Data;Data Set;Dementia;detection platform;Devices;Diagnosis;Diagnostic;diagnostic tool;digital;Disease;Disease Progression;Disparate;driving behavior;Early Diagnosis;Early identification;Early treatment;Engineering;Environment;Fingerprint;functional decline;Functional impairment;Goals;health care availability;High Performance Computing;Impairment;improved;indexing;Individual;innovation;Intervention;Light;Location;Machine Learning;Measures;Mediating;Mediator;Medicine;meetings;mild cognitive impairment;Modeling;Monitor;Motor;National Institute on Alcohol Abuse and Alcoholism;normal aging;novel;older driver;older patient;Patients;Pattern;Persons;Phase;Play;pre-clinical;prevent;Quality of life;Recording of previous events;Records;Research Project Grants;Risk;Role;Rural;rural setting;Safety;Sampling;screening;sensor;sensor technology;Severities;Signal Transduction;Sleep;statistical and machine learning;success;supervised learning;Syndrome;System;Taxonomy;Techniques;Testing;Time;Transportation;United States National Institutes of Health;urban setting;Visual;wearable data;wearable device;wearable sensor technology;Weather

PROJECT_TITLE: Monitoring real-world driver behavior for classification and early prediction of Alzheimer’s disease

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Alzheimer's disease (AD) is a major public health problem. Currently there is no effective treatment for AD. Genetic studies aiming to improve our understanding of the pathogenesis of AD and underlying mechanisms may contribute to personalized medicine goals and better therapies and/or preventive measures This study is focused to delineate the genetic basis of two AD-specific proteinopathies, amyloid-beta (Aβ) and pathologic tau, by whole-genome-sequencing. The successful completion of the proposed comprehensive study using biomarkers of two AD-specific proteinopathies in living people with well characterized amyloid-PET and CSF Aβ42/tau datasets along with clinical outcomes of dementia followed by functional studies will make a major contribution to our understanding of the pathogenesis of AD and underlying mechanisms, which may contribute to personalized medicine goals and better therapies and/or preventive measures.

PI_NAMEs: CRUCHAGA, CARLOS ;KAMBOH, M. ILYAS (contact)

PROGRAM_OFFICER_NAME: FENG, LI REBEKAH

PROJECT_TERMS: abeta deposition;Acceleration;Affect;Age;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;Amyloid beta-42;Amyloid beta-Protein;amyloid pathology;Apolipoprotein E;Automobile Driving;Autopsy;Bioinformatics;Biological;Biological Markers;biomarker validation;Brain;Brain Diseases;Cell model;Cell Physiology;Cerebrospinal Fluid;Clinical;clinical diagnosis;comorbidity;Data;Data Set;Dementia;diagnostic value;Disease;effective therapy;endophenotype;Etiology;experimental study;extracellular;fluorodeoxyglucose positron emission tomography;follow-up;Gene Expression;Genes;Genetic;genetic architecture;genetic association;genetic information;Genetic study;genetic variant;Genetic Variation;Genome Scan;genome sequencing;genome wide association study;Genomics;Genotype;Goals;Impaired cognition;improved;In Vitro;Individual;interest;Intervention;Magnetic Resonance Imaging;Measures;Mediation;Mendelian randomization;Methods;Myeloid Cells;National Institute on Aging;Nature;Nerve Degeneration;Neurofibrillary Tangles;neuroimaging;Neuronal Injury;neuropathology;novel;Outcome;Pathogenesis;Pathologic;Pathologic Processes;Pathology;Pathway interactions;personalized medicine;Persons;Phase;Phenotype;Plasma;polygenic risk score;population based;Positron-Emission Tomography;pre-clinical;prevent;Preventive measure;Proxy;Public Health;Quantitative Trait Loci;rare variant;Recommendation;Research;Research Subjects;Risk;Role;Sampling;Senile Plaques;Signal Transduction;Symptoms;tau Proteins;tau-1;Testing;Variant;whole genome

PROJECT_TITLE: Genetic Architecture of Alzheimer’s disease Proteinopathies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-B(02)M]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lung;Networking and Information Technology R&D (NITRD)

PI_NAMEs: PRESNELL, SCOTT  (contact)

PROJECT_TERMS: Acute;Archives;Asthma;atopy;B-Cell Antigen Receptor;Biological;Cells;Clinical;Clinical Data;Consultations;Cytometry;Data;data acquisition;Data Analyses;data analysis pipeline;data integration;data management;data resource;Data Security;Data Set;data sharing;data standards;Data Storage and Retrieval;data tools;database of Genotypes and Phenotypes;design;Disease;DNA Methylation;Ensure;experience;experimental analysis;Experimental Designs;Genetic;genomic data;Genomics;Goals;high dimensionality;Immunology;Infrastructure;large scale data;Leadership;longitudinal analysis;member;Membrane Proteins;Metadata;Monitor;National Institute of Allergy and Infectious Disease;Phase;Phenotype;Process;programs;Proteomics;Reporting;repository;Research Institute;Research Personnel;Research Project Grants;Resources;respiratory infection virus;Rheumatoid Arthritis;Sampling;Services;Site;System;T-Cell Receptor;Techniques;tool;transcriptome;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Universities;Update;Viral;Viral Respiratory Tract Infection;viral RNA;Visualization;Vulnerable Populations;Washington;Work


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE A long-standing goal of neuroscience is to understand how cognitive functions are implemented through interactions of large neural ensembles in order to provide practical solutions for altering cognitive behavior through manipulations of neural circuits. Here, we develop a theoretical framework to infer functional causal interactions through sparse sampling of large neural ensembles and test our framework on the prefrontal cortex of the monkey brain. This advance enables us to innovate a technique for targeted manipulation of the prefrontal circuit and alter the monkey’s cognitive behavior in real-time, a key step toward advanced brain- machine interfaces and novel enhancing or therapeutic interventions in the human brain.

PI_NAMEs: KIANI, ROOZBEH  (contact);MAZZUCATO, LUCA

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TITLE: Causal power of cortical neural ensembles: mechanisms and utility for brain perturbations

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Bioengineering;Cancer

PHR: The proposed research is relevant to the mission of the NCI because elucidating the mechanisms of fluid shear stress resistance in circulating tumor cells, and the consequences of this for metastasis, will open new possibilities for cancer diagnosis and treatment, broadly applicable to many cancer types. This fundamental knowledge will inform our understanding of the metastatic process, the cause of lethality in most cancer patients.

PI_NAMEs: HENRY, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Actomyosin;Animal Model;Behavior;Biological Assay;Biological Markers;Biomechanics;Blood flow;Cancer Biology;cancer cell;cancer diagnosis;Cancer Patient;cancer therapy;cancer type;Cardiovascular system;Cell Survival;Cells;Circulation;clinically actionable;Data;Diagnostic;Disease;Drug Sensitization;effectiveness evaluation;Epithelial Cells;Event;experience;Exposure to;Extravasation;Genes;genetic analysis;Genetic Screening;Genetic Transcription;Goals;hemodynamics;Immune mediated destruction;improved;in vivo;innovation;insight;Intervention;knock-down;Knowledge;Liquid substance;Literature;Lung;Malignant Neoplasms;Measures;mechanical force;Mechanics;Mediating;metastatic process;Microcirculation;Mission;Molecular;mouse model;Neoplasm Circulating Cells;Neoplasm Metastasis;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;Outcome;Pharmaceutical Preparations;Plasma;Predisposition;prevent;Primary Neoplasm;Productivity;programs;Publishing;Research;Resistance;response;Role;shear stress;Solid Neoplasm;Testing;Therapeutic;Tissues;Traction;Tumor Cell Biology;tumor microenvironment

PROJECT_TITLE: Influence of hemodynamic shear stress on circulating tumor cells

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ED_INST_TYPE: SCHOOLS OF EDUCATION

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Nutrition;Obesity;Pain Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE Chronic widespread pain (CWP) is an obesity-related disparity that disproportionately burdens non-Hispanic Black and Hispanic/Latino/a/x adults with obesity. Bariatric surgery is often prescribed for obesity and musculoskeletal pain comorbidities, but there is significant intra-group variability in pain improvement. The proposed work will identify key driver(s) of pain resolution or maintenance after bariatric surgery that could serve as targets for culturally informed, multimodal pain interventions for adults with obesity.

PI_NAMEs: MERRIWETHER, ERICKA NAYRAM (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Adult;adult obesity;Affect;Age;Anxiety;bariatric surgery;Behavioral;biobehavior;biopsychosocial;biosignature;Black race;Body Weight decreased;career;career development;chronic pain;chronic widespread pain;Classification;Clinical;Clinical Research;Clinical Trials Design;Communities;comorbidity;conditioned pain modulation;demographics;Development Plans;Dimensions;disability;Disparity;Environment;ethnic diversity;Ethnic Origin;Evaluation;experience;fall risk;Feasibility Studies;Fiber;Florida;Fostering;Foundations;Gender Identity;General Population;Goals;Health Disparities Research;health disparity;Health equity research;Hispanic;Hospitals;improved;Incubators;indexing;innovation;Institution;Intervention;Joints;Knowledge;Latina;Latino;Latinx;Latinx population;Life Style;Lower Extremity;Maintenance;Measurement;Measures;mechanical load;Mechanics;Mediating;Mediation;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;Methods;Modeling;Motion;Movement;multimodality;Musculoskeletal;Musculoskeletal Pain;New York;Nociception;Not Hispanic or Latino;Obesity;Pain;pain inhibition;Pain management;Pain Measurement;pain outcome;pain perception;pain reduction;Pain Research;pain sensitivity;Pain Threshold;Participant;Patient Self-Report;Patients;Phenotype;phenotypic data;Physical therapy;Population;Population Heterogeneity;pressure;primary outcome;psychosocial;Psychosocial Factor;Race;racial difference;racial diversity;recruit;Recurrence;Refractory;rehabilitation research;Research;research and development;Research Project Grants;Research Training;Resolution;Resources;response;Rest;Sensory;Site;Sleep disturbances;Standardization;Statistical Methods;Stress;synergism;Testing;Time;Training;translational scientist;Universities;Weight;Weight maintenance regimen;Work

PROJECT_TITLE: Determining Mechanisms of Pain Reduction in Chronic Widespread Pain After Rapid Weight Loss in Non-Hispanic Black and Hispanic/Latino/a/x Adults

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ORG_CITY: BOSTON

ORG_DEPT: PHYSICS

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: PROJECT NARRATIVE Photomedicine avoids traditional side effects of systemic chemotherapy, yet effective outcomes are dependent on direct irradiation from an external light source that limits the scope and the types of cancers that may be treated. This proposal develops a precision photomedicine platform that exploits natural disease-homing properties of the immune system to mediate bioluminescent-activated phototherapy, which will be evaluated in 3D cancer–immune co-culture and a mouse model of cancer metastases by paring with our tumor-targeted, activatable photoimmunotherapy platform. Successful, proof-of-concept studies will establish a new paradigm of systemic, whole-body phototherapy by enabling immune cell-based light delivery to deep and diffuse metastatic disease that would otherwise be impractical to treat using an external light source, thereby overcoming a major limitation of conventional phototherapy.

PI_NAMEs: SPRING, BRYAN QUILTY (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: 3-Dimensional;Abdomen;Adoption;Antibodies;Antigens;Apoptotic;Area;Biological Markers;Bioluminescence;bioluminescence imaging;Calibration;cancer cell;Cancer Model;cancer type;Carcinoma;Carcinomatosis;Cell Culture Techniques;Cell Death;Cell Line;Cell Therapy;Cells;cellular engineering;Cetuximab;Chemicals;Chemoresistance;Chemotaxis;chemotherapy;Clinic;clinical translation;Clinical Trials;clinically relevant;Coculture Techniques;Collaborations;combat;Combined Modality Therapy;comorbidity;Complex;cost effective;Creativeness;Cytoplasm;cytotoxic;delivery vehicle;Deposition;design;Development;Diffuse;Disease;disease model;Disseminated Malignant Neoplasm;Dose;Dose Limiting;dosimetry;Drug Delivery Systems;Drug resistance pathway;efficacy study;Engineering;Ensure;Enzymes;Esophagus;Exhibits;experimental study;Fiber Optics;Flow Cytometry;Fluorescence Microscopy;Funding;Future;Generations;Genetic Engineering;genetically modified cells;Goals;high reward;high risk;Homing;Human;Immune;Immune system;Immunologic Surveillance;In Vitro;in vivo;Infusion procedures;Injections;innovation;intraperitoneal;intravenous injection;irradiation;Kidney;Lasers;Lesion;Light;Liver;Macrophage;Malignant Neoplasms;Mediating;Methods;Modeling;Monitor;Monte Carlo Method;mouse model;Mus;nano;nanoparticle;nanoparticle delivery;Nature;Neoplasm Metastasis;novel;novel therapeutics;Outcome;Output;Pathway interactions;Patients;Penetration;Peritoneal;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;photoactivation;photoimmunotherapy;photonics;Photons;Photosensitizing Agents;Phototherapy;Production;programs;Property;Prostate;Proteins;Protocols documentation;PUVA Photochemotherapy;recruit;refractory cancer;Research;safety study;Semiconductors;Shock;side effect;simulation;Singlet Oxygen;Site;Skin;Source;spheroids;subcutaneous;Superficial Lesion;synergism;T cell therapy;T-Lymphocyte;Technology;Testing;Therapeutic;Therapeutic Index;Tissues;Toxic effect;Translations;Treatment Efficacy;tumor;tumor specificity;Tumor-infiltrating immune cells;Universities;Verteporfin;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Disease-homing light delivery by engineering bioluminescent immune cells for whole body precision photomedicine


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Social adversity is strongly associated with susceptibility to diseases of aging, as well as with lifespan itself. These patterns are also observable in other social mammals, suggesting that animal models can be strategically leveraged to understand how social environments influence aging in humans. This proposal supports a Research Network for integrating animal models into studies of social aging, with the goal of mentoring and recruiting new investigators, building visibility across disciplines, and ultimately producing a self- sustaining research community that helps improve human health and well-being during aging.

PI_NAMEs: BARTOLOMUCCI, ALESSANDRO ;HARRIS, KATHLEEN MULLAN;TUNG, JENNY  (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Address;Advanced Development;Age;Aging;aging population;aging related disease;Alcoholism;American;animal data;Animal Experimentation;Animal Model;animal model development;Animals;Applications Grants;Area;Articulation;Awareness;Behavior Therapy;Behavioral;behavioral study;biodemography;Biological;Biological Assay;Biological Markers;Cardiovascular Diseases;career;Catalysis;Clinical Research;Collaborations;Collection;Communities;comparative;Complex;Controlled Environment;cost;Data;Data Set;data sharing;Death Rate;Dementia;design;Dimensions;Discipline;Educational workshop;Environment;Etiology;Exhibits;experience;experimental study;Fellowship;flexibility;Generations;genomic data;Goals;Grant;Health;Human;human data;human model;human population study;improved;innovation;Interdisciplinary Communication;interest;Knowledge;Leadership;life span;Link;low socioeconomic status;Malignant Neoplasms;Mammals;Marmota;meetings;Mentors;Mentorship;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;Nature;nonhuman primate;Obesity;Outcome Measure;Paper;Pathway interactions;Pattern;Personal Satisfaction;Physiological;Pilot Projects;Population;Population Study;Predisposition;programs;Protocols documentation;Publications;R24;recruit;Research;Research Design;Research Personnel;Rodent;Scientist;sedentary;Silk;social;social adversity;Social Behavior;social determinants;Social Environment;social factors;social health determinants;Social Impacts;Social Interaction;Social isolation;social relationships;social stress;Social support;Socioeconomic Status;Standardization;Stress;symposium;Technology;Testing;therapeutic evaluation;Therapeutic Intervention;Time;tool;Training;translational applications;Translations;Travel;United States;Work;working group

PROJECT_TITLE: Research Network on Animal Models to Understand Social Dimensions of Aging


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Organ Transplantation;Transplantation

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE: Heart transplantation is a potentially life-saving treatment for end-stage heart failure but unfortunately donors are scarce and only a fortunate minority of patients receive hearts. Current heart allocation policy relies on the intensity of treatment to decide who receives a heart, but this system cannot consistently identify the sickest candidates who stand to benefit the most from heart transplantation. This proposal aims to improve heart allocation by 1) developing a data-driven, objective heart allocation score with cutting-edge machine learning techniques, and 2) building novel, more flexible simulation software.

PI_NAMEs: PARKER, WILLIAM F (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Adult;American;candidate identification;career;Charge;Clinical;clinical practice;Communities;Complex;Data;Data Set;design;Disease;Doctor of Philosophy;Effectiveness;Ensure;Ethics;Event;experience;flexibility;Foundations;Future;Goals;health care delivery;Health Policy;Health Resources;Health Services Research;Healthcare;Heart;Heart failure;Heart Transplantation;high risk;improved;Life;Machine Learning;machine learning prediction;Medical;Minority;Modeling;models and simulation;mortality risk;novel;open source;organ allocation;organ procurement transplantation network;Organ Procurements;Organ Transplantation;Outcome;Patients;Performance;Physicians;Policies;Policy Analysis;post-transplant;predictive modeling;Prognosis;programs;Publishing;Registries;Research;Resource Allocation;Resources;risk stratification;Scientist;simulation;simulation software;skills;Source;Statistical Methods;Statistical Models;Supportive care;System;Techniques;Testing;tool;Training;transplant centers;transplant registry;Transplantation;United States Dept. of Health and Human Services;Update;Waiting Lists

PROJECT_TITLE: Mending a Broken Heart Allocation System with Machine Learning

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Pediatric;Physical Activity;Prevention;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE With more than 1,000 Fontan palliations performed in children with single ventricles in the US every year, there is a burgeoning population of Fontan patients at risk for progressive heart failure and death. The proposed research will assess the impact of a live-video-supervised exercise intervention on key health measures that have been associated with poor long-term outcomes in pediatric Fontan patients. Our ultimate goal is the translation of this model to clinical application as an ”exercise prescription” to intervene early in pediatric Fontan patients and decrease long-term morbidity and mortality, in alignment with the NIH’s mission to develop evidence-based data for new approaches to improve outcomes in youth with chronic conditions.

PI_NAMEs: BERNSTEIN, DANIEL ;PALANIAPPAN, LATHA P;SELAMET TIERNEY, ELIF SEDA  (contact)

PROGRAM_OFFICER_NAME: EGERSON, D'ANDREA R

PROJECT_TERMS: 19 year old;Accelerometer;Adherence;adherence rate;Admission activity;Adolescent;Adolescent and Young Adult;Adolescent obesity;Adrenergic beta-Antagonists;Adult;Aerobic;Age;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Arginine;arm;Biological Markers;Brain natriuretic peptide;Cardiac;Cardiopulmonary;cardiorespiratory fitness;Cessation of life;Chemicals;Child;Child Health;Childhood;Chronic;clinical application;Common Ventricle;congenital heart abnormality;Creatine;Data;design;Disease Progression;Dual-Energy X-Ray Absorptiometry;Echocardiography;effectiveness evaluation;endothelial dysfunction;Endothelium;Equipment and supply inventories;evidence base;Exercise;exercise capacity;exercise intervention;exercise prescription;Exercise stress test;fitness;Goals;Health;Heart;Heart failure;heart function;Heart Transplantation;improved;improved outcome;indexing;Intervention;Leg;Magnetic Resonance Imaging;Measures;Methylation;Mission;Modality;Morbidity - disease rate;mortality;Movement;multidisciplinary;muscle form;Muscle function;Muscle Mitochondria;muscle strength;neonatal period;Nitrates;Nitric Oxide;Nitric Oxide Pathway;Nitrites;Nonpharmacologic Therapy;novel;novel strategies;novel therapeutic intervention;Outcome;palliation;Patients;Physical activity;Physical Capacity;physical conditioning;Physical Function;Physiologic pulse;Plasma;Population;prevent;primary outcome;Quality of life;Questionnaires;Randomized;randomized, clinical trials;Randomized, Controlled Trials;reduced muscle mass;Reproducibility;Research;Resistance;Risk;Scanning;Schools;Site;success;Testing;therapy design;Thinness;translational model;Transplant Recipients;Transportation;treatment as usual;Treatment Failure;United States National Institutes of Health;Videoconferencing;VO2max;Work;Youth

PROJECT_TITLE: RE-ENERGIZE FONTAN - RandomizEd Exercise INtERvention desiGned to MaximIZE Fitness in Pediatric FONTAN patients

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(OA)]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Lung cancer remains the leading cause of cancer-specific mortality in the US, and Hispanics experience worse lung cancer outcomes due to advanced stage at presentation. Lung cancer screening (LCS) can save lives and improve disparities through early detection among Hispanic current and former smokers. Still, without tailored interventions, Hispanics will continue to die from lung cancer at higher rates. This K08 NCI proposal entitled Health Opportunities & Promoters of Equitable Screening for Lung Cancer (HOPES for Lung Cancer) offers an innovative approach to promote LCS uptake among Hispanic current and former smokersby elucidating barriers and facilitators to consistent documentation of smoking status to promote LCS uptake opportunities and leveraging the rise of digital health to assess the reach of the digital delivery of an educational video tailored to promote LCS uptake among Hispanic communities.

PI_NAMEs: FLORES, EFREN  (contact)

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TERMS: acceptability and feasibility;Address;Area;Award;Awareness;Cancer Etiology;cancer health disparity;cancer survival;career;career development;Charge;Clinic;Clinical;Collaborations;Communities;community based participatory research;Community Health;Community Networks;community partnership;cost;COVID-19;Data;Dedications;Development Plans;digital delivery;digital health;digital intervention;Disclosure;Disparity;Documentation;Early Diagnosis;Education;Education and Outreach;Educational Intervention;Electronic Health Record;Electronic Mail;Elements;Eligibility Determination;Environment;Equity;evidence base;experience;Focus Groups;former smoker;Foundations;Fright;Guidelines;Health;health record;Healthcare Systems;Hispanic;hispanic community;Hispanic Populations;Hospitals;improved;Individual;innovation;Institution;interest;Intervention;intervention delivery;intervention effect;K-Series Research Career Programs;Leadership;low socioeconomic status;lung basal segment;lung cancer screening;Malignant neoplasm of lung;Mental Health;Mentors;Mentorship;Methods;Modality;Modeling;mortality;National Institute on Minority Health and Health Disparities;Not Hispanic or Latino;novel;Outcome;outreach;Participant;Patient Participation;patient portal;Patients;Physicians;pilot trial;Population;Positioning Attribute;prevent;promoter;Provider;Publishing;Radiology Specialty;Research;Research Personnel;research study;Resources;satisfaction;Schedule;Scientist;screening guidelines;screening participation;severe mental illness;Smoker;smoking cessation;Smoking Status;social culture;Surveys;Text Messaging;Theoretical model;Training;Training Support;trial enrollment;Underserved Population;United States Preventative Services Task Force;uptake;Vulnerable Populations;Work

PROJECT_TITLE: Health Opportunities & Promoters of Equitable Screening for Lung Cancer (Hopes for Lung Cancer)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]