NIH_SPENDING_CATS: Genetics

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: NARRATIVE: Interleukin-13 (IL-13) is a crucial effector cytokine in causing allergic inflammation and in immunity against certain parasitic infections. By better understanding the transcriptional codes that drive rapid and robust Il13 gene transcription, we will provide a novel mechanistic insight into how enhancers cooperate to transcribe the Il13 gene rapidly and robustly and identify targets for CRISPR-based therapies to disrupt cytokine and chemokine-mediated inflammatory pathways.

PI_NAMEs: HUANG, HUA  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Affinity;Allergic inflammation;Antigens;Binding;Binding Sites;Biological Assay;Biotin;chemokine;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complex;CRISPR therapeutics;CRISPR/Cas technology;crosslink;cytokine;Cytokine Gene;Data;detection method;Disease;DNA;DNA-Protein Interaction;Effector Cell;EGR2 gene;Enhancers;Family;Genes;Genetic Transcription;Genomic approach;Goals;Health;Homeobox;IgE;IL13 gene;Immunity;improved;Inflammatory;insight;Interleukin-13;Label;mast cell;Mediating;Methods;mouse model;novel;Output;Parasitic infection;Pathway interactions;promoter;Proteins;Publishing;receptor;Reporter Genes;response;Rest;Role;Signal Transduction;Sum;Testing;transcription factor;Transcriptional Regulation;Work;Zinc Fingers

PROJECT_TITLE: Transcriptional Regulation of the Il13 Gene in Mast Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-M(90)]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Project Narrative T cell-mediated rejection remains a significant obstacle to improving long-term allograft survival, yet the underlying mechanisms remain poorly understood. Our project aims to investigate the role of alloreactive T cells in driving transplant rejection and identify potential strategies for targeting these T cells, with significant clinical implications.

PI_NAMEs: CHEN, WENHAO  (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Ablation;Adoptive Transfer;Alloantigen;Allogenic;allograft rejection;Allografting;anti-CTLA-4 therapy;anti-CTLA4;anti-PD-L1;Automobile Driving;Cell Count;cell injury;Cell Transplantation;Cells;Cellular Stress;Chromatin;Clinical;CTLA4 gene;CTLA4-Ig;CXCR6 gene;DNA;drug withdrawal;effector T cell;Enzymes;Epigenetic Process;EZH2 gene;FK506;Frequencies;Functional disorder;Gene Expression;Gene Expression Profiling;Genetic Transcription;Goals;Graft Rejection;heart allograft;Heart Transplantation;Immune;immune checkpoint blockade;Immunosuppression;Immunosuppressive Agents;improved;inhibitor;insight;IRF4 gene;Mediating;Metabolic;Mitochondria;Modeling;Mus;Outcome;post-transplant;prevent;programmed cell death ligand 1;Regimen;Regulatory T-Lymphocyte;Research;Role;self-renewal;Sirolimus;T cell differentiation;T cell response;T-Lymphocyte;Tacrolimus;TCF Transcription Factor;Testing;Time;TNFSF5 gene;transcription factor;Transplant Recipients;Transplantation;treatment duration

PROJECT_TITLE: Impact of Irreversible T Cell Dysfunction on Transplant Outcomes

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative: Mast cells (MC) are potent inflammatory cells that accumulate within airway and digestive mucosal tissues during type 2 inflammatory diseases, including asthma, nasal polyposis, food allergy, and eosinophilic esophagitis, where they take on discrete intraepithelial and parenchymal phenotypes based on their tissue microenvironment. While each population is known to carry a discrete protease phenotype, the degree to which these populations differentially contribute to tissue inflammation is poorly understood. We have developed a novel cell culture system allowing the differentiation of both phenotypes from human peripheral blood progenitors, allowing direct comparison of the effector function of these two phenotypes. Using these systems, we have discrete cytokine and pro-inflammatory eicosanoid production profiles from the two phenotypes in response to activation and find that they both differentially respond to stimulus with type 2 inflammation-associated cytokines, all of which reflect the in vivo transcriptomic phenotype of intraepithelial versus parenchymal mast cells within human nasal polyps. This proposal seeks to comprehensively characterize the effector function of both subsites as a first step in understanding their relative contribution to human disease in vivo.

PI_NAMEs: DWYER, DANIEL F (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Affinity;Asthma;Automobile Driving;CD34 gene;Cell Culture System;Cell Differentiation process;Cell Maturation;Cell surface;Cell Surface Receptors;Cells;chemokine;chronic rhinosinusitis;Chymase;Connective Tissue;Coupled;crosslink;cysteinyl-leukotriene;cytokine;Cytokine Signaling;Data;Data Set;Development;differential expression;differentiation in vitro;Disease;Effector Cell;Eicosanoid Production;Eicosanoids;Environment;Enzymes;Eosinophilic Esophagitis;Epithelium;Exhibits;experimental study;falls;Food Hypersensitivity;genetic signature;Genetic Transcription;Growth Factor;Hematopoietic stem cells;Heterogeneity;Human;human disease;Hyperplasia;IgE;IgE Receptors;In Vitro;in vivo;Inflammation;Inflammatory;Interleukin-13;Interleukin-4;Interleukin-5;intraepithelial;Knowledge;Lavage;Link;lipid mediator;lipidomics;Literature;Location;Macrophage Colony-Stimulating Factor;mast cell;Measures;Mediator;Mucous Membrane;Mus;Nasal Polyps;Nose;novel;Pathway interactions;Patients;Peptide Hydrolases;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;Phenotype;Play;polyposis;Population;Production;programs;Proteins;Respiratory Mucosa;response;Role;Series;Shapes;Signal Transduction;Signal Transduction Pathway;single-cell RNA sequencing;Sinus;Stimulus;System;Testing;Therapeutic Intervention;Time;Tissues;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;Tryptase;Up-Regulation;Vascular Endothelial Growth Factors

PROJECT_TITLE: Defining Heterogeneous Human Mast Cell Effector Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (09)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Adaptive auditory processing is critical for navigating everyday listening situations that are dynamic and context-dependent and is known to be compromised in conditions such as aging and hearing loss. The experiments outlined in this proposal will investigate the circuit and physiological mechanisms underlying adaptive processing. Therefore, the proposed experiments may identify how adaptive processing is implemented in normal listening situations and lay the groundwork for investigating how it may be altered in pathological states.

PI_NAMEs: LESICKO, ALEXANDRIA MARIE (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Address;Affect;Aging;Anatomy;Anterior;Area;Attention;attentional modulation;Auditory;Auditory area;auditory processing;Auditory system;auditory thalamus;Behavior;Behavioral;Behavioral Paradigm;behavioral response;Brain;Brain region;Calcium;cingulate cortex;Clutterings;Code;Cognition;cohort;Cues;Electrophysiology (science);Environment;Experimental Designs;experimental study;flexibility;Frequencies;Goals;hearing impairment;Image;Impairment;Inferior Colliculus;Label;Masks;Medial geniculate body;Mediating;Methods;Midbrain structure;Mus;Neurons;Noise;optogenetics;Pathologic;Pathway Analysis;Pathway interactions;Perception;Performance;Peripheral;Physiological;Play;Process;receptive field;receptor;recruit;response;restoration;Rewards;Role;Sensory;sensory system;sound;speech in noise;statistics;Stimulus;Structure;Techniques;Testing;Time;Training;two-photon;Water

PROJECT_TITLE: Top-down mechanisms underlying contextual and adaptive processing in the auditory system

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (03)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Cancer stem cells drive growth and resistance of glioblastoma, the most common primary malignant brain tumor; however, the development of anti-cancer stem cell therapies has been limited by the identification of targetable signaling nodes. We have observed that glioblastoma cancer stem cells require the presence of connexin 43 (Cx43), a gap junction protein that is challenging to specifically target due to its function in non-transformed cell types and due to its homology to other connexin proteins. The objective of this project is to gain mechanistic insight into a signaling network downstream of Cx43 with the goal of identifying targetable downstream signaling nodes.

PI_NAMEs: MULKEARNS-HUBERT, ERIN E. (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Aftercare;anti-cancer;Applications Grants;Astrocytes;Automobile Driving;Behavior;Biological Assay;Biology;Brain;cancer cell;cancer stem cell;Cell Communication;Cell Separation;Cell Survival;cell type;Cells;Chemotherapy and/or radiation;Communication;Complex;Connexin 43;Connexins;Cues;Data;Development;Diffuse;Disease;Excision;experimental study;Funding Mechanisms;Future;Gap Junctions;Gene Expression;Genes;Genetic Transcription;GJB2 gene;Glioblastoma;Goals;Growth;Heterogeneity;Human;in vivo;inhibitor;insight;knock-down;Laboratories;leukemia;Link;Lysine;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Mediator;Messenger RNA;Modeling;Molecular;Mus;mutant;MYC Family Protein;Nature;neoplastic cell;nerve stem cell;novel;novel therapeutics;Operative Surgical Procedures;Output;overexpression;patient derived xenograft model;Patients;Phenocopy;Phosphoproteins;Phosphorylation;Phosphotransferases;Population;Primary carcinoma of the liver cells;Protein Deficiency;Protein Kinase;Protein-Serine-Threonine Kinases;Proteins;Proto-Oncogene Proteins c-akt;Recurrent tumor;refractory cancer;Reporting;Resistance;response;RNA;Role;self-renewal;Serine;Signal Transduction;standard of care;stem cell proliferation;stem cell survival;stem cell therapy;Testing;Therapeutic;therapeutic development;therapy resistant;thymocyte;Transcript;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor initiation;tumor microenvironment;Tumor Promotion;Work

PROJECT_TITLE: Connexin 43 drives glioblastoma cancer stem cells through a WNK1 signaling axis

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Prevention;Substance Misuse

ORG_CITY: CHARLESTON

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The addition of new caging in the Medical University of South Carolina’s Division of Laboratory Animal Resources facility will increase housing density allowing investigators to expand their research leading to new discoveries sooner. Specifically, these discoveries will enable to advances in understanding alcohol addiction and treatments. It will also result in increased workforce efficiencies, the application of energy-efficient green technologies and will allow a novel use of remote microenvironment monitoring.

PI_NAMEs: HELKE, KRISTI  (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: Accreditation;Address;Air;alcohol abuse therapy;Alcohol dependence;alcohol research;Allergens;Animal Experimentation;animal facility;Animal Housing;Animal Husbandry;Animal Model;animal resource;Animals;Area;Behavior;Behavioral;biobehavior;biomarker development;Biomedical Research;Caring;Collaborations;college;Complex;Computer software;cost;dander;Data;density;Disinfection;energy efficiency;Environment;Equipment;ergonomics;Excision;Exposure to;Faculty;Floor;Frequencies;Friends;Funding;Future;gaze;germ free condition;Goals;Grant;Growth;Health;Health protection;Housing;Human;human disease;human model;Human Resources;improved;Individual;Injury;innovation;Institution;International;Laboratory Animal Production and Facilities;Laboratory Animals;Letters;Licensing;Maintenance;Malignant Neoplasms;Medical;metabolomics;Methodology;Monitor;Motion;Mus;neuropsychiatry;Neurosciences;novel;Occupational Health;Outcome;pathogen;Plumbing;Population Density;prevent;Productivity;programs;Rattus;Regenerative Medicine;remote control;remote monitoring;Reproducibility;Request for Proposals;Research;research and development;Research Personnel;Research Support;Resources;Risk;Rodent;Rodent Model;Safety;Sales;Services;Shipping;South Carolina;Study models;Substance abuse problem;Substance Use Disorder;System;Taxes;Technology;Time;translational scientist;Transportation;United States Department of Agriculture;United States National Institutes of Health;Universities;Vent;ventilation;Viral;wasting;Water;Work;Workplace

PROJECT_TITLE: Modernizing microenvironment monitoring and increasing housing capacity through cutting-edge technologies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-U (91)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Contraception/Reproduction;Estrogen;Mental Health;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Narrative The current project will evaluate the neural mechanisms underlying menstrual cycle phase and hormonal effects on response inhibition and working memory in females with ADHD. In addition, the project will determine whether and how well cycle phase and hormonal effects on neural function during cognitive tasks predict ADHD symptoms and treatment response.

PI_NAMEs: MARTEL, MICHELLE M (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: Adolescence;Adolescent;Adult;Adult women;Age;Alcoholic beverage heavy drinker;animal data;Animals;Attention;Attention deficit hyperactivity disorder;Back;Basic Science;Biological;Brain;caudate nucleus;Childhood;Clinical;Cognition;Cognitive;cognitive task;comorbidity;Data;design;Dopamine;Estradiol;Estrogen decline;Estrogens;Feasibility Studies;Female;Goals;Gonadal Steroid Hormones;Hormonal;Hormones;Human;hypothalamic pituitary gonadal axis;Impairment;improved;Inferior;innovation;Link;Longitudinal Studies;male;Mediating;Menstrual cycle;neural circuit;neurobiological mechanism;Neurobiology;Neurocognitive;neuromechanism;Neurophysiology - biologic function;Ovarian hormone;Ovariectomy;Participant;Pattern;perimenstrual;Pharmaceutical Preparations;Pharmacotherapy;Phase;phase change;Population;Prevalence;Progesterone;psychopharmacologic;psychostimulant;Puberty;Quasi-experiment;Rattus;reproductive;Research Design;response;Risk;Risk Factors;Sampling;sex;Short-Term Memory;symptom treatment;Symptoms;Testing;theories;Titrations;Translating;treatment response;Withdrawal;women patients;Work;young adult

PROJECT_TITLE: Neural Mechanisms of Menstrual Cycle Effects on ADHD and Cognition

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Narrative Aβ pathology is a prevailing hallmark of Alzheimer’s disease (AD). This proposal aims to validate the pathogenic role of the APP E590D variant in human fibroblast-converted neurons as well as to generate and characterize the APP E590D-based knock-in mouse model for AD study.

PI_NAMEs: LIU, TIAN  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: abeta accumulation;abeta deposition;abeta oligomer;Abeta synthesis;AD transgenic mice;Age;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Amyloid deposition;Antibodies;beta secretase;beta-site APP cleaving enzyme 1;Biological;Brain;C-terminal;Case Study;Cell Line;Cell surface;Cells;Classification;Data;Dementia;Early Endosome;Early Onset Alzheimer Disease;Early Onset Familial Alzheimer's Disease;Endocytosis;Event;extracellular;Face;Fibroblasts;Functional disorder;gamma secretase;Gene Proteins;Generations;Genetic;Gliosis;Goat;Human;Hypertension;Impaired cognition;Impairment;In Vitro;in vivo;inhibitor;Investigation;Knock-in;Knock-in Mouse;knockin animal;Late Onset Alzheimer Disease;Mass Spectrum Analysis;Medical History;Membrane Potentials;Mitochondria;mitochondrial dysfunction;Modeling;mouse model;Mus;mutant;Mutate;Mutation;Neurobehavioral Manifestations;Neurofibrillary Tangles;Neurons;Neuropsychological Tests;Neuropsychology;older patient;Outcome;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Peptides;Phenotype;Physiological;Play;Process;protein degradation;protein expression;protein structure;Proteins;Proteolysis;Proteomics;Published Comment;Reporting;Research;Research Personnel;Respiration;Role;Senile Plaques;Site;Superoxides;Surface;Symptoms;Synapses;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;Variant;Visuospatial

PROJECT_TITLE: Pathogenic Role of APP E590D in Alzheimer’s Disease.

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Maternal Health;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Physiologic changes during pregnancy and the postpartum period (often overlooked periods of the lifespan) include dramatic adaptations in immune response. We hypothesize that the dynamic, programmed changes in immune response through pregnancy and postpartum will alter the interactions between virome and host, revealing important underlying biology of the virome-maternal-fetal unit.

PI_NAMEs: ERNST, LINDA M;STOUT, MOLLY ;WYLIE, KRISTINE M. (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: adaptive immunity;Adult;adverse pregnancy outcome;Affect;aged;Allografting;bacteriome;Basal Plate;Biological Assay;Biology;Blood;Blood Tests;Cells;Chorionic villi;Clinical;cohort;Communities;Complex;congenital infection;cytokine;Cytometry;Data;Disease;DNA;DNA Viruses;Enrollment;Equilibrium;fetal;Foundations;Funding;Future;Genotype;Gestational Age;Grant;Health;Human;Human Microbiome;human virome;Image;Immune;immune activation;Immune response;Immunologics;Immunology;improved;Individual;Infection;Inflammation;Inflammatory Response;Knowledge;Legal patent;life span;Link;Maternal-Fetal Exchange;Maternal-fetal medicine;Methods;microbiome;microbiome components;Modification;Monitor;multidimensional data;Natural Immunity;Nucleic Acids;Oral;Outcome;pathogen;Pathologic;Pathology;Physiological;Physiology;Placenta;Postpartum Period;Pregnancy;prospective;Publications;racial diversity;reproductive;RNA Viruses;Role;Sampling;Site;statistics;success;Swab;systemic inflammatory response;Testing;Tissues;transcriptome sequencing;transcriptomics;Vagina;Viral;viral detection;viral genomics;Viral Physiology;virology;virome;Virus;virus host interaction;Work

PROJECT_TITLE: Dynamic changes in virome-host interactions during pregnancy and postpartum

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-E (50)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Neurodegenerative;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative  Developing disease-modifying therapies for neurodegenerative diseases is a challenging task. This study will develop new statistical strategies that accurately estimate the disease course using five longitudinal datasets of Huntington disease, a genetic neurodegenerative disease. This administrative supplement will offer both research and career development opportunities to Mr. Vazquez, an exceptional doctoral student in biostatistics at the UNC Gillings School of Global Public Health, so he may pursue the development of statistical strategies that more accurately predict disease course and improve patient selection for future clinical trials.

PI_NAMEs: GARCIA, TANYA PAMELA (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Administrative Supplement;Affect;aging related disease;Alzheimer's Disease;Biological Markers;Biometry;career;career development;clinical diagnosis;Clinical Trials;Clinical Trials Design;cohort;Communication;Data;Data Set;design;Development;Diagnosis;Disease;disease model;doctoral student;Dropout;experience;Faculty;Funding;Future;Genetic;Gills;Grant;Huntington Disease;improved;Individual;innovation;Lead;longitudinal dataset;Measurement;Measures;meetings;Mentors;Methods;model building;Modeling;Motor;Neurodegenerative Disorders;novel;open source;Oral;parent grant;Parkinson Disease;Patient Selection;Patients;Peer Review;Positioning Attribute;prevent;Process;programs;Public Health;Research;research and development;Research Personnel;Risk;Schools;Science;Scientist;Side;Source Code;Statistical Models;Symptoms;Testing;theories;Time;Training;training opportunity;United States National Institutes of Health;Validation;Visit;Work;Writing

PROJECT_TITLE: Diversity Supplement: Developing a robust and efficient strategy for censored covariates to improve clinical trial design for neurodegenerative diseases


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: DURHAM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE We will examine the temporal and geographic correlations of structural racism, natural disaster susceptibility, and rates of behavioral health outcomes in Texas and Louisiana. Additionally, we will assess how Hurricane Harvey shaped behavioral health outcomes and the extent to which these outcomes differ based on county levels of structural racism. Finally, we will engage in collaborative data analysis with community members in Houston to optimize interpretation and actionability of results.

PI_NAMEs: BRINKLEY-RUBINSTEIN, LAUREN  (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Address;Anxiety;Area;behavioral health;Belief;Black Populations;Black race;Code;Collaborations;Communities;community collaboration;community engagement;community organizations;community-level factor;comorbidity;County;Data;Data Analyses;Databases;Demographic Factors;Disasters;Discrimination;Disease;Disparity;Emergency department visit;epidemiologic data;epidemiology study;Equity;ethnic difference;ethnic disparity;ethnic health disparity;ethnic minority population;Ethnic Origin;experience;Focus Groups;Fostering;Geography;Harm Reduction;Health;health care service utilization;health disparity;health equity;Home;Hospitalization;Hurricane;ICD-9;Imprisonment;Income;indexing;Inequity;innovation;Inpatients;interest;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Intervention;Latinx population;lens;Linear Models;Literature;Long-Term Effects;Louisiana;low socioeconomic status;Maps;Measures;medication for opioid use disorder;member;Mental Depression;Mental disorders;Mental Health;minority health;multidisciplinary;National Institute of Drug Abuse;Natural Disasters;Outcome;Overdose;overdose death;Ownership;Participant;Pattern;Persons;Play;Poisson Distribution;Post-Traumatic Stress Disorders;Predisposition;Race;racial difference;racial disparity;Racial Equity;racial health disparity;racial minority population;Research;Resource Allocation;Resources;response;Risk;Role;Services;Shapes;Societies;spatiotemporal;structural determinants;Structural Racism;substance use;symptomatology;System;Texas;theories;Time;treatment services;United States;United States National Institutes of Health;Veins;Voice;Vulnerable Populations;Work

PROJECT_TITLE: The Contribution of Structural Racism to the Long-Term Effects of Natural Disaster on Behavioral Health Outcomes (SALENDO)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKM-E (M1)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: The direct impact of this research is the clear prospect that new molecular information regarding the cause of Parkinson's disease and related dementias will become available. Armed with this understanding, it should be possible to achieve more effective treatments that will slow the progression of the disease. More generally, the ability to access protein conformation information in vivo has broad ramiﬁcations in studies of human disease extending beyond Parkinson's disease.

PI_NAMEs: WEBB, KEVIN J (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: 3-Dimensional;3D Print;Address;alpha synuclein;Amyloid;Animals;beta pleated sheet;Brain;Calibration;Cell Membrane Permeability;Cell Separation;cell type;Cells;Cre lox recombination system;Cytosol;Data;Dementia;Development;Digestion;Disease;Disease Progression;Dyes;Economic Burden;effective therapy;Endocytosis;Endopeptidase K;Engineering;Environment;experimental study;Fluorescence;fluorescence imaging;fluorescence lifetime imaging;Fluorescence Resonance Energy Transfer;Fluorescent Dyes;fluorophore;Gel Chromatography;Goals;human disease;human induced pluripotent stem cells;Image;imaging modality;in vivo;in vivo imaging;Incubated;Induced pluripotent stem cell derived neurons;innovation;innovative technologies;insight;Knowledge;Label;Lentivirus;Lewy Bodies;Lewy body pathology;Light;Location;Mammalian Cell;Maps;Measurement;Mediating;Membrane;Methods;microscopic imaging;Modeling;Molecular;Monitor;motor disorder;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuronal survival;Neurons;neuropathology;new technology;novel therapeutics;Optics;Parkinson Disease;Pathologic;Pathology;Patients;Permeability;Persons;Phospholipids;Positioning Attribute;pre-formed fibril;prion-like;Process;protein aggregation;Protein Conformation;Proteins;Rattus;Recombinants;Reporting;Research;Resolution;Rodent;Role;self assembly;Testing;Therapeutic;therapy design;therapy development;Time;Tissues;Transmission Electron Microscopy;United States;uptake;Variant;Vesicle;Visualization

PROJECT_TITLE: Optical Sensing of the Spread of Alpha-Synuclein Aggregates in Models of Parkinson's Disease and Related Dementias


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Social Determinants of Health;Telehealth

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Approximately 1 in 2 children in foster care exhibit a clinically significant mental health (MH) need, less than ¼ of those children receive treatment, and those who do – experience over a decade delay in seeking treatment. This project will test a family navigator program (FN+) to build foster parent capacity to: 1) recognize their child’s specific MH needs and address any preliminary barriers to treatment; 2) work with the child’s caseworker to engage the child in mental health services; 3) manage the child’s difficult behaviors; 4) overcome barriers to treatment access and use digital mental health tools, and 5) support treatment goals at home. Outcomes include foster parent activation, reduced barriers to treatment, and perceived change in child behavior.

PI_NAMEs: BOISSEAU, CHRISTINA LYNN;RISSER, HEATHER JILL (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: 17 year old;acceptability and feasibility;access disparities;Address;aged;Anxiety Disorders;Area;attentional control;barrier to care;Behavior;burden of illness;care seeking;care systems;Caring;Child;Child Behavior;Child Mental Health;child mental health service;Child Welfare;Childhood;Clinic;Clinical;clinically significant;Communities;Community Health Aides;Complex;cost effective;Data;Data Collection;Depressive disorder;design;Development;Diagnosis;digital mental health;Disparity;disparity reduction;Early treatment;effective therapy;Effectiveness;Elements;Eligibility Determination;Enrollment;Exhibits;experience;Family;Family Caregiver;Family health status;Feasibility Studies;feasibility testing;Feedback;Focus Groups;follow-up;foster care;foster child;foster parent;Fostering;Goals;health assessment;Health Personnel;Health Services Accessibility;high risk;high risk population;Home;human centered design;Illinois;implementation strategy;improved;Individual;innovation;Interview;Knowledge;Leadership;Licensing;Life;maltreatment;Measures;Mental association;Mental disorders;Mental Health;Mental Health Services;Methods;Modeling;Outcome;Parents;Patient Self-Report;Patients;Perception;Population;post intervention;Preparation;primary outcome;Procedures;Process;programs;promote resilience;Protocols documentation;Provider;Randomized;Randomized, Controlled Trials;recruit;Role;satisfaction;secondary outcome;Services;skills;social media;Spanish;Specialist;Structure;Suicide attempt;Symptoms;telehealth;Testing;Time;tool;Training;Trauma;traumatized children;treatment as usual;virtual;welfare;Well in self;Work;Youth

PROJECT_TITLE: Building Capacity for Youth Mental Wellness: Feasibility and Acceptability for a Mental Health Family Navigator Model for Foster Parents.

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


PHR: Project Narrative  Developing disease-modifying therapies for neurodegenerative diseases is a challenging task. This study will develop new statistical strategies that accurately estimate the disease course using five longitudinal datasets of Huntington disease, a genetic neurodegenerative disease. This administrative supplement will offer both research and career development opportunities to Mr. Kyle Grosser, an outstanding doctoral candidate in biostatistics at the UNC Gillings School of Global Public Health, so he may develop statistical strategies that more accurately predict disease course and inform the selection of outcomes used in clinical trials of Huntington disease.

PROJECT_TERMS: Administrative Supplement;Affect;aging related disease;Alzheimer's Disease;Biological Markers;Biometry;career;career development;clinical diagnosis;Clinical Trials;Clinical Trials Design;cohort;Communication;Data;Data Set;design;Development;Diagnosis;Disease;disease model;Dropout;Elements;Faculty;Funding;Future;Genetic;Gills;Grant;Huntington Disease;improved;Individual;innovation;Instruction;Lead;longitudinal dataset;Measurement;Measures;meetings;Mentors;Methods;model building;Modeling;Motor;Neurodegenerative Disorders;novel;open source;Oral;Outcome;parent grant;Parkinson Disease;Patients;prevent;programs;Public Health;Research;research and development;Research Personnel;Risk;Schools;Science;Scientist;Source Code;Statistical Models;symposium;Symptoms;Testing;theories;Time;training opportunity;United States National Institutes of Health;Validation;Visit;Work;Writing


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Contraception/Reproduction;Infectious Diseases;Infertility;Pelvic Inflammatory Disease;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: 8. Project Narrative Research in this grant will investigate a new therapeutic strategy for preventing pelvic inflammatory disease (PID) associated infertility. Currently there are no effective treatments to prevent PID infertility. Results of this work may greatly improve the reproductive health of women.

PI_NAMEs: JOHNSON, RAYMOND MORRIS (contact)

PROGRAM_OFFICER_NAME: YATES, FRANKLIN WILLEM

PROJECT_TERMS: Acute;Adoptive Transfer;Affect;Affinity;Antibiotic Therapy;Antibiotics;antimicrobial;Apoptosis;Back;Bacterial Genes;Bacterial Genome;Binding;Biological;Biological Assay;Blocking Antibodies;Breeding;C57BL/6 Mouse;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cervical;Cervix Uteri;Chlamydia;Chlamydia muridarum;Chlamydia trachomatis;chronic infection;Clinic;Clinical Trials;Code;Data;data modeling;Development;Dexamethasone;Diagnosis;disease model;Doxycycline;Ectopic Pregnancy;effective therapy;effector T cell;efficacy evaluation;Endometritis;Epidemiology;Evaluation;Female infertility;Fever;gene synthesis;Genes;Genomics;Gonorrhea;Grant;Histopathology;Homeopathy;Hospitalization;Human;humanized monoclonal antibodies;IgG4;Immune response;immunopathology;improved;Incidence;Infection;Infection prevention;infection risk;Infertility;Interferon Type II;Intervention;Investigation;Laboratories;Macaca;Malignant Neoplasms;Mammalian Oviducts;Measures;Mediator;Medical;Modeling;Monoclonal Antibodies;mouse model;Mus;Natural Immunity;Non-Steroidal Anti-Inflammatory Agents;novel therapeutic intervention;Ovarian;Pain;pathogen;Pathway interactions;Pelvic Inflammatory Disease;Pelvic Pain;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Positioning Attribute;pre-clinical;Predisposition;Prevalence;prevent;Public Health;Rattus;Receptors, Tumor Necrosis Factor, Type II;Recording of previous events;Regulatory T-Lymphocyte;Research;Risk;Rodent;Role;Salpingitis;Sexually Transmitted Diseases;Steroids;STI prevention;Synteny;T-Cell Activation;T-Cell Receptor;Technology;Testing;therapeutic candidate;Therapeutic Intervention;TNF gene;TNFRSF1A gene;TNFRSF1B gene;Transgenic Mice;Translational Research;tumor;Vaginal Discharge;Variant;Woman;women's reproductive health;Work

PROJECT_TITLE: TNFR2 blockade prevention of STI infertility

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Infectious Diseases;Microbiome;Orphan Drug;Rare Diseases

ORG_DEPT: DENTISTRY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative Oral cancer is a deadly and a debilitating disease that continues to have poor prognosis despite advances in treatment modalities including surgery, radiotherapy and immunotherapy. The use of bacteria as anticancer agents is an emerging therapeutic approach. This study will investigate the impact of two commensal bacterial species found in the oral cavity on development of oral cancer and its response to immunotherapy in mice.

PI_NAMEs: AL-HEBSHI, NEZAR  (contact);WHELAN, KELLY A

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: 16S ribosomal RNA sequencing;4-Nitroquinoline-1-oxide;Address;Adverse effects;Animals;anti-cancer;anti-PD1 antibodies;anti-tumor agent;anti-tumor immune response;Antineoplastic Agents;Apoptosis;Area;Bacteria;biomarker selection;C57BL/6 Mouse;cancer cell;cancer immunotherapy;carcinogenesis;CD36 gene;Cell Culture Techniques;Cell Cycle Regulation;Cell Line;Chemicals;Clinical;commensal bacteria;Cyclin-Dependent Kinases;Cyclins;cytotoxicity;Data;Development;digital imaging;Disease;Dose;Down-Regulation;drinking water;Engineering;Epithelium;Evaluation;Exposure to;Financial Hardship;Flow Cytometry;Fluorescent in Situ Hybridization;Foundations;Gel;Genetic Transcription;germ free condition;Germ-Free;Goals;gut microbiome;Haemophilus parainfluenzae;Health;Histopathologic Grade;Histopathology;human subject;Hydrogen Peroxide;immune cell infiltrate;Immune checkpoint inhibitor;immune modulating agents;Immune response;Immune system;Immunoglobulin G;Immunohistochemistry;Immunotherapy;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory;Inhibition of Cell Proliferation;innovation;interest;Intervention;Intraperitoneal Injections;Invaded;Knowledge;lipid metabolism;malignant mouth neoplasm;Malignant Neoplasms;Mediating;Metalloproteases;microbiome;Modality;Molecular;mouth squamous cell carcinoma;Mouthwash;Mus;novel;novel therapeutic intervention;Operative Surgical Procedures;Oral;oral bacteria;oral carcinogenesis;Oral cavity;oral commensal;oral microbiome;Outcome;pathobiont;Pathogenicity;Pathway interactions;Pilot Projects;Play;Porphyromonas gingivalis;Prevention;Preventive;primary outcome;Production;Prognosis;programmed cell death ligand 1;Proliferating;Property;Radiation therapy;Regulatory Pathway;Research;response;Role;Sampling;Signal Transduction;Streptococcus mitis;Swab;Technology;Testing;Therapeutic;Time;Tissues;Tongue;Tongue Neoplasms;Toxic effect;transcriptome;transcriptome sequencing;transcriptomics;translational impact;translational potential;tumor;Tumor Burden;Tumor Immunity;tumor microenvironment;Up-Regulation;Work

PROJECT_TITLE: Health-associated oral bacteria as anti-cancer and immunomodulatory agents in oral cancer

STUDY_SECTION: TIO

STUDY_SECTION_NAME: Translational Immuno-oncology Study Section[TIO]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung

ORG_CITY: BATON ROUGE

ORG_NAME: REFINED IMAGING, LLC

ORG_STATE: LA

PHR: 8. Narrative According to PAR-22-073, this narrative document is not required as a separate document, but it is included in the Research Strategy section as; Executive Summary and Project Plan.

PI_NAMEs: MATTHEWS, KENNETH L (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Chronic Obstructive Pulmonary Disease;COVID-19;imaging system;Interferometry;Lung;Lung Diseases;Research;Roentgen Rays;Validation

PROJECT_TITLE: Implementation and validation of a lung x-ray interferometry imaging system, with applications to COPD, COVID-19 and other lung diseases


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

PHR: PROJECT NARRATIVE A major contribution to cancer drug resistance is that cancer cells can move into and out of different drug resistance states. This work aims to build computational models of the timing and probabilities of these events and how drugs affect them, so that better combination therapies can be designed.

PI_NAMEs: BIRTWISTLE, MARC R. (contact);GALLO, JAMES M.;LAO, YEH-HSING

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: 3-Dimensional;Address;Affect;anti-cancer;Antineoplastic Agents;Astrocytes;Bar Codes;Behavior;Biological Assay;blood-brain barrier penetration;Brain Neoplasms;cancer cell;cancer drug resistance;cancer therapy;Cell Communication;Cell Culture Techniques;Cell Cycle;Cell model;cell type;Cells;Cerebral endothelium;chemotherapy;clinically relevant;Coculture Techniques;Combined Modality Therapy;Computer Models;Data;Data Set;Death Rate;design;Development;discrete time;Dose;Drug Combinations;Drug resistance;drug sensitivity;Drug Targeting;drug-sensitive;Epigenetic Process;Event;experimental study;FDA approved;flexibility;Flow Cytometry;Genetic;Glioblastoma;Glioma;glioma cell line;Growth;Heterogeneity;Homeostasis;Human;Hybrids;Image;Immunofluorescence Immunologic;in vivo;kinase inhibitor;Knowledge;Least-Squares Analysis;live cell imaging;machine learning method;Malignant Neoplasms;markov model;Measurement;Mediating;Mesenchymal;Methods;Modeling;Modernization;Monitor;monolayer;neoplastic cell;nerve stem cell;network models;Neurons;Nuclear Pore Complex;oligodendrocyte progenitor;organ on a chip;Pathway interactions;patient derived xenograft model;Patients;Pattern;Pharmaceutical Preparations;phosphoproteomics;Physical assessment;Population;Population Growth;predictive modeling;Probability;programs;Proteins;Publishing;Regimen;Resistance;resistance mechanism;response;screening;single-cell RNA sequencing;Sorting;standard of care;System;temozolomide;Testing;theories;therapy design;Time;Tissues;transcriptome;transcriptome sequencing;transcriptomics;tumor;Update;Work

PROJECT_TITLE: Cell State Network-Directed Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-X (M1)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Relapsed acute lymphoblastic leukemia (ALL) is a leading cause of cancer death in children/adolescents, and Philadelphia chromosome-like ALL is a common, high-risk subtype characterized by miswired signaling, high relapse rates, and extremely poor survival. Our research uses systems biology approaches to identify how changes in multiple pathways at the single-cell level may lead to leukemia resistance and relapse. Through these studies, we hope to improve our understanding of the critical biologic mechanisms driving this high-risk leukemia and to develop more effective combination precision medicine therapies to cure patients.

PI_NAMEs: DING, YANG-YANG  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acute leukemia;acute lymphoblastic leukemia cell;Acute Lymphocytic Leukemia;Adolescent;Adult Acute Lymphocytic Leukemia;Advisory Committees;Apoptosis;Apoptotic;ATAC-seq;Automobile Driving;B-Cell Acute Lymphoblastic Leukemia;BCL2 gene;Big Data;Bioinformatics;Biological;Biology;c-myc Genes;Cancer Etiology;career;Cell Cycle;Cell Cycle Arrest;Cell Line;Cell Proliferation;Cells;Cellular biology;Cessation of life;Chemoresistance;Child;Childhood Acute Lymphocytic Leukemia;childhood cancer mortality;ChIP-seq;Chronic;Clinical;clinical translation;Clinical Trials;Clinical Trials Design;clinically relevant;Combined Modality Therapy;Complex;Computational Biology;Dasatinib;Data;Data Set;Dependence;design;Diagnosis;DNA;Drug Targeting;early phase clinical trial;Environment;Epigenetic Process;Evolution;experience;experimental study;Future;Gene Expression Profile;gene regulatory network;Genes;Genetic;genetic signature;Genetic Transcription;Genomics;Goals;Growth;Harvest;Heterogeneity;high risk;Human;improved;In Vitro;in vivo;in vivo Model;inhibitor;inhibitor therapy;insight;International;K-Series Research Career Programs;knock-down;Knock-out;leukemia;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Mentors;Mentorship;Methodology;Modeling;molecular targeted therapies;multidisciplinary;multiple omics;Mutation;non-genetic;oncogene addiction;Oncogenic;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Pharmacotherapy;Phenotype;Philadelphia Chromosome;Phosphotransferases;Population;pre-clinical;precision medicine;precision medicine clinical trials;Proliferating;Recurrence;Relapse;Research;Research Personnel;Resistance;resistance mechanism;Resources;risky driving;Role;Scientist;Signal Transduction;single cell analysis;skills;synergism;System;Systems Biology;targeted agent;targeted treatment;Techniques;Therapeutic;therapy resistant;Time;Training;transcription factor;transcription regulatory network;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;Translating;translational physician;translational scientist;treatment response;Tyrosine Kinase Inhibitor;Validation

PROJECT_TITLE: Elucidating Critical Dependencies Underlying Therapeutic Evasion in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Cannabinoid Research;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Services;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE A subset of pregnant and lactating (“perinatal”) people are persistently using cannabis despite knowledge of its association with negative parental-child outcomes, and materials are needed to train medical providers in how to discuss perinatal cannabis use with patients in a way that effectively promotes health. This study has the potential to impact public health by creating, in collaboration key informants (patients, providers, leaders in healthcare and public health), a toolkit to enable US medical provider adoption of a harm reduction approach to the discussion of perinatal cannabis use with patients. The proposed project will advance the care of perinatal patients by equipping medical providers with the tools necessary to support patients in reducing health harms related to cannabis use.

PI_NAMEs: ALBANESE, ARIANA  (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Abbreviations;Adopted;Adoption;adverse outcome;Area;Behavior;Breast Feeding;Canada;Cannabis;Child;Clinical;Collaborations;Community Health Aides;Complex;Counseling;Development;Drug Controls;Education;Effectiveness;effectiveness/implementation study;Elements;evidence base;Evidence based practice;Explosion;Feedback;formative assessment;Frequencies;Future;Guidelines;Harm Reduction;Health;Health behavior;Health Promotion;Health Services;Healthcare;Hybrids;implementation efforts;implementation science;implementation strategy;implementation study;Individual;informant;Interview;Knowledge;knowledge integration;Lactation;Legal;Link;marijuana use;marijuana use in pregnancy;Medical;medical examination;Methodology;Modeling;modifiable risk;National Institute of Drug Abuse;Nicotine;Opioid replacement therapy;Outcome;patient subsets;Patients;Perception;Perinatal;perinatal cannabis use;Perinatal Care;perinatal period;Persons;Phase;Philosophy;Physicians;Population;Positioning Attribute;Pregnancy;pregnant;Promoting Action on Research Implementation in Health Services framework;prototype;Provider;provider adoption;Public Health;Recommendation;Reporting;Research;Research Priority;Resources;Risk;Risk Factors;Safety;skills;Social Workers;substance use;Substance Use Disorder;System;Testing;Tetrahydrocannabinol;tool;Training;Training Support;United States;United States Substance Abuse and Mental Health Services Administration;uptake;user centered design

PROJECT_TITLE: Towards a harm reduction approach to perinatal cannabis use

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Cancer;Complementary and Integrative Health;Digestive Diseases;Nutrition;Obesity;Pancreatic Cancer;Prevention;Rare Diseases

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE Obesity and excessive fat consumption increase the risk of pancreatic cancer, but how they contribute to tumor development is not completely understood. In the parent R01, we aimed to determine how dietary fatty acids directly modulate pancreatic lipid composition to drive tumorigenesis. In this supplement, we focus on the downstream effects of these dietary fatty acids on pancreatic cell metabolism, which may lead to novel targeted dietary and pharmacologic strategies for the prevention of pancreatic cancer and other obesity-driven cancers.

PI_NAMEs: MUZUMDAR, MANDAR DEEPAK (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: 3-Dimensional;Acceleration;Acinar Cell;Adipose tissue;Albumins;Award;Binding;Cancer Biology;cancer care;Cancer Etiology;career;Cell Culture System;Cell model;Cells;Cellular Metabolic Process;Cessation of life;cohort;Computing Methodologies;Consumption;Country;Cultured Cells;Data;Data Analyses;Development;Diet;Diet Research;dietary;dietary excess;Dietary Fats;Dietary Fatty Acid;driving force;Duct (organ) structure;Ductal Epithelial Cell;experience;experimental study;FASN gene;Fatty acid glycerol esters;Fatty Acids;feeding;Genes;Genetic;Genetic Models;Genetically Engineered Mouse;Goals;Grant;Health;High Fat Diet;Histologic;Human;human disease;In Vitro;in vitro Model;in vivo;inhibitor;Intake;Integration Host Factors;Isotopes;Knock-out;Knowledge;KRAS oncogenesis;Link;Lipase;lipid metabolism;Lipid Peroxidation;lipidomics;Lipids;long chain fatty acid;Lysophospholipids;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuscripts;Membrane;Mentorship;Metabolic;Metabolism;Metaplasia;Methods;Monounsaturated Fatty Acids;mouse model;Mus;non-genetic;Nonesterified Fatty Acids;novel;Obesity;Oleic Acids;Organoids;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;pancreatic tumorigenesis;Parents;Pathway interactions;pharmacologic;Phospholipids;Plasma;Polyunsaturated Fatty Acids;Population;Postdoctoral Fellow;premalignant;Prevalence;Prevention strategy;Process;Production;Radioactive;receptor;Research;Risk;Scientist;Side;skill acquisition;Source;Supplementation;Survival Rate;Testing;Time;Tissues;Tracer;Training;tumor;tumor progression;Tumor Promotion;tumorigenesis;United States;Up-Regulation;uptake;Variant;Work;Writing

PROJECT_TITLE: Dietary fatty acids drive pancreatic cancer development


ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Consent, assent, and decision-making are regularly encountered in the clinical and research settings but can be stymied in youth and adults with Down syndrome (DS). This supplement will add 1) two sites (Miami and San Antonio) and 2) an investigator new to research in people with DS and from a background considered under- represented in research in its efforts to conduct a national patient-centered study of a diverse group of people with DS and caregivers on the use of multi-media materials to promote understanding/appreciation of study purpose, procedures, risks/benefits and decision-making involvement.

PI_NAMEs: KELLY, ANDREA BRIDGET (contact);MILLER, VICTORIA ALLISON

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Address;Administrative Supplement;Adolescent and Young Adult;Adult;Advocate;Area;Benefits and Risks;Caregivers;Child Development;Chronic;Clinical;Clinical Research;clinical trial readiness;cognitive ability;Collaborations;Communication;Communication Barriers;Comprehension;Consent;Country;Creativeness;Data;Decision Making;decision research;demographics;Development;Disparity;Down's Syndrome;Education;Educational Materials;Elements;Enrollment;Ethnic Origin;Exclusion;experience;Faculty;Family;Family Research;Feedback;Fostering;Friends;Geographic Locations;Health;Health Sciences;Hispanic Populations;Home;human subject protection;Human Subject Research;Individual;Informed Consent;Infrastructure;Intellectual functioning disability;interactive tool;interest;Intervention;Interview;Investigation;Learning;Learning Disabilities;life span;Limited English Proficiency;Medical;Methodology;Modeling;Morals;multidisciplinary;Multimedia;Neurocognitive;Paper;Participant;patient oriented;Patients;Performance;Persons;Philadelphia;Population;Population Heterogeneity;Procedures;Process;programs;Provider;Questionnaires;Race;recruit;Regulation;Research;Research Institute;Research Methodology;Research Personnel;Role;Rural;Sampling;Self Efficacy;Services;shared decision making;Site;Sleep;Sleep Apnea Syndromes;social;Spanish;Structure;Techniques;Testing;Texas;Text;tool;Training;Translating;Translations;trial comparing;Universities;Update;verbal;virtual;Visual;Voice;Vulnerable Populations;web app;Work;Writing;young adult;Youth

PROJECT_TITLE: Leveraging E-education to Advance Assent and Decision-Making Involvement in Down Syndrome Administrative Supplement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(80)-R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Palliative Care;Pediatric

ORG_NAME: INNOVATION RESEARCH AND TRAINING, INC.

PHR: NARRATIVE Pediatric clinical trials are important for discovering new and effective medicines, treatments, devices, and interventions specifically designed for children and adolescents. Decision-making about clinical trial participation includes both parents and adolescents; however, limited research has directly examined their decision-making process and how this process may impact parents’ and adolescents’ pediatric clinical trial decisions and communication satisfaction. Understanding the unique and dyadic effects of parents’ and adolescents’ communication and decision-making can inform pediatric clinical trial recruitment strategies and decision aids with the goal of improving clinical trial accrual.

PI_NAMEs: PARKER, ALISON ELAINE (contact);SCULL, TRACY MARIE

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: Adolescence;Adolescent;Attitude;Behavior;Caregivers;Child;Child Rearing;Childhood;Clinical Research;clinical trial recruitment;Clinical Trials;Code;Collaborations;Communication;communication behavior;Consent;Data;Decision Aid;Decision Making;design;Development;Device Designs;Devices;education resources;Educational Intervention;educational resource development;Empirical Research;Enrollment;Ethnic Origin;experience;Family;Family Research;family support;follow-up;Gender;Goals;Health;Healthcare;high risk;improved;informant;innovation;interest;Intervention;Interview;Medicine;Methodology;Methods;Modeling;Nature;novel;Observational Study;Outcome;parent-child communication;Parents;Patient Self-Report;Persons;Physicians;Play;Process;Questionnaires;Race;Recording of previous events;recruit;Reporting;Research;research and development;Risk;Role;Sampling;satisfaction;shared decision making;Side;social influence;Structure;Subgroup;Teenagers;theories;therapy design;Transact;Videotape;Work;Youth

PROJECT_TITLE: Examination of parent-adolescent shared decision-making about participation in pediatric clinical trials

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: DK

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;Nutrition;Obesity;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative In this proposal, we will seek to investigate the efficacy and mechanisms of a novel small molecule with inhibitory activities of non-canonical IkB kinases, TBK1 and IKKe, in alleviating hyperglycemia by (1) improving pancreatic islet cell function and (2) mitigating adiposity via stimulating energy expenditure to achieve enhanced glycemic control in obesity-linked diabetic models. The outcomes of the proposed studies will make a significant breakthrough for developing highly translational therapeutic strategies to mitigate obesity-linked diabetes.

PI_NAMEs: SHIN, CHONG H (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Abbreviations;acrylic acid;Acute;Alpha Cell;amlexanox;analog;Animal Model;Attenuated;azastene;Behavioral;Beta Cell;Blood Glucose;Body Weight;Body Weight decreased;Cell model;Cell Physiology;cinnamic acid;clinical development;Data;db/db mouse;Desire for food;Deterioration;Diabetes Mellitus;diabetic;Diabetic mouse;diabetogenic;diet-induced obesity;Disease remission;Dose;Drug Kinetics;Eating;efficacy evaluation;Energy Metabolism;Exhibits;Exposure to;Fatty acid glycerol esters;Functional disorder;Gene Expression;Glucagon;Glucose;glucose metabolism;glucose tolerance;glycemic control;Goals;High Fat Diet;Homologous Gene;Human;hydroxamate;hyperglucagonemia;Hyperglycemia;Hypoglycemic Agents;Impairment;improved;In Vitro;in vivo;Inflammation;inhibitor;Insulin Resistance;insulin secretion;insulin sensitivity;Investigation;islet;Islets of Langerhans;Life Style;Link;Marketing;Medical;Metabolic;Modeling;mouse model;Mus;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Obese Mice;obese patients;Obesity;Oral;Oral Administration;Outcome;oxidation;Palmitates;Patients;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Phosphotransferases;Population;Prevalence;Property;Publishing;reduced food intake;Regimen;response;restoration;Scourge;side effect;small molecule;Structure-Activity Relationship;TANK-binding kinase 1;Testing;Therapeutic;therapeutic evaluation;Time;Tissues;Translating;translational therapeutics

PROJECT_TITLE: Small molecules targeting obesity-linked diabetes

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Narrative Corneal epithelium is maintained by limbal stem cells and loss of limbal stem cells results in limbal stem cell deficiency; the patients suffer from severe vision loss due to the ingrowth of cloudy conjunctiva. We propose to reveal the characteristics of limbal niche cells such as limbal fibroblasts and limbal dendritic cells, evaluate the interaction of limbal niche cells and limbal epithelial cells, and establish limbal fibroblast injection method for the treatment of LSCD. Successful completion of this project will improve our understanding of limbal niche cells in normal and LSCD conditions, and provide us with novel strategic option to treat LSCD, namely limbal fibroblast injection.

PI_NAMEs: SASAMOTO, YUZURU  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Address;Affect;Animal Experiments;Apical;Area;Autologous Transplantation;Awareness;Bilateral;Blindness;Cd68;Cell Maintenance;Cells;Characteristics;Clinical;conjunctiva;Cornea;corneal epithelium;corneal regeneration;Data;Dendritic Cells;Engraftment;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;epithelial stem cell;Epithelium;experience;Eye;FGFR2 gene;Fibroblast Growth Factor Receptors;Fibroblasts;Flow Cytometry;Functional disorder;Goals;Growth;Homologous Transplantation;Human;human induced pluripotent stem cells;IL1R1 gene;Immune;improved;In Vitro;induced pluripotent stem cell;Injectable;Injections;Interleukin-1 beta;ITGAX gene;keratinocyte growth factor;Keratoplasty;Lead;limbal;Maintenance;Measures;melanocyte;Methods;migration;Modeling;Mus;novel;Organoids;Outcome;Patients;PDGFA gene;PDGFB gene;PDGFRA gene;Phenotype;Physiologic Intraocular Pressure;Platelet-Derived Growth Factor;platelet-derived growth factor BB;Play;Population;Positioning Attribute;Postoperative Complications;Production;PTPRC gene;Publishing;receptor;Recovery;Recurrence;Reporting;Resource-limited setting;response;Role;single-cell RNA sequencing;Source;Stem Cell Research;stem cells;success;Techniques;Therapeutic;Tissues;Transplantation

PROJECT_TITLE: The role of limbal fibroblasts for the maintenance of limbal stem cells

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Neurosciences;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Herpes simplex viruses persists for life in neurons as a latent infection and can reactivate to cause disease. The aims of this study are to understand the how abundantly expressed neuronal protein, ATRX, promotes both establishment of HSV latency and also prevents reactivation occurring. The long-term goals are to understand how HSV gene silencing occurs in neurons for the development of therapeutics that can target the latent stage of infection.

PI_NAMEs: CLIFFE, ANNA RUTH (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Animal Model;Animals;Binding;Biological Models;Body Surface;cell type;Cellular Stress;Chromatin;Clinical;Data;DAXX gene;Deposition;Development;Disease;DNA Viruses;Encephalitis;Ensure;Environment;Epigenetic Process;Gene Expression;gene repression;Gene Silencing;Genetic Transcription;Genome;Goals;Herpes Simplex Infections;Heterochromatin;Histone H3;Histones;human pathogen;In Vitro;in vitro Model;in vivo;Individual;Infection;innovation;Knock-out;latent infection;Lesion;Life;Lysine;lytic gene expression;Maintenance;Mediating;Methamphetamine;Methylation;Methyltransferase;Modeling;Modification;Molecular Chaperones;Mutation;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Disorder;neuron development;Neurons;nondeletion type alpha-thalassemia/mental retardation syndrome;Nuclear;Outcome;Pathway interactions;Phosphorylation;Population;prevent;Production;Productivity;protein function;Proteins;reactivation from latency;Reading;Repression;response;Role;Simplexvirus;Stimulus;Structure;targeted treatment;Testing;therapeutic development;therapy development;Time;Viral;Viral Genome;viral transmission;Virus;Virus Latency;Work

PROJECT_TITLE: The role of ATRX in both promoting the establishment of HSV latency and restricting reactivation

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Gene Therapy;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: NARRATIVE Targeted gene therapy approaches are reemerging as attractive experimental clinical agents; our ligand-directed hybrid virus of adeno-associated virus and bacteriophage (AAVP) is a targeted gene delivery vector that has been used in several formulations displaying targeting ligand peptides to deliver clinically applicable transgenes. Here we will evaluate a novel combination of two AAVP constructs to target multiple compartments and deliver tumor necrosis factor (TNF) in a clinically relevant model of breast cancer. The double-cyclic RGD4C motif ligand is specific for alpha v integrins expressed in tumor cells and associated vasculature, and the recently reported CSSTRESAC peptide ligand is specific for protein disulfide-isomerase A3 (PDIA3), a novel marker on the surface of tumor associated macrophages, and displays immunoregulatory activity.

PI_NAMEs: ARAP, WADIH ;PASQUALINI, RENATA  (contact)

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: Ablation;advanced disease;angiogenesis;Animals;Anti-Inflammatory Agents;anti-microbial drug;Antibiotics;Apoptosis;Bacteriophages;Binding;Biological;breast cancer diagnosis;Breast Cancer Model;Breast Cancer Patient;Breast Carcinoma;Bystander Effect;cancer subtypes;Canis familiaris;Capsid Proteins;Caspase;Cell Death;Cell surface;Cell Surface Receptors;Cell Survival;Cells;chemotherapy;Clinical;clinical application;clinically relevant;CMV promoter;cohort;Combined Modality Therapy;comparative;Complex;Control Animal;conventional therapy;cytokine;Data;Data Set;Dedications;delivery vehicle;density;Dependovirus;Development;Disease;Disease Progression;Distant Metastasis;DNA cassette;DNA Sequence;Dose;Elements;Engineering;Ensure;Enzyme-Linked Immunosorbent Assay;ERBB2 gene;Estrogen Receptors;Eukaryotic Cell;Formulation;Gene Delivery;Gene Expression;Gene Proteins;gene therapy;Gene Transduction Agent;gene-targeted therapy;Genes;Genome;Genomics;Human;Hybrids;Immune;Immune Evasion;Immunologic Markers;Immunologics;immunoregulation;Immunosuppression;Immunotherapy;Infiltration;Inflammatory;insight;Integrin alphaV;Inverted Terminal Repeat;Investigation;ITGAM gene;Ligands;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mammalian Cell;Mammary Neoplasms;Measures;Mediating;mimetics;Minor;Modeling;Molecular Biology;molecular recognition;Molecular Target;molecular targeted therapies;Mus;Nature;neoplastic cell;new therapeutic target;novel;novel marker;oncology trial;Outcome;overexpression;Pathogenesis;Patients;Peptides;Periodicity;Population;Pre-Clinical Model;preclinical development;Progesterone Receptors;Prognosis;Protein Disulfide Isomerase;Publications;Quantitative Reverse Transcriptase PCR;Radiation therapy;Rattus;receptor;Receptor Protein-Tyrosine Kinases;Reporting;response;Role;Safety;Sampling;Satellite Viruses;Signal Transduction;Solid Neoplasm;standard of care;Subgroup;Surface;Survival Rate;systemic toxicity;targeted agent;targeted delivery;targeted treatment;Terminal Repeat Sequences;Therapeutic;Therapeutic Agents;therapeutic gene;therapeutic target;Tissues;TNF gene;Transcript;Transduction Gene;transgene expression;Transgenes;Treatment Protocols;triple negative cancer;triple-negative invasive breast carcinoma;Tropism;tumor;Tumor Markers;tumor microenvironment;Tumor Necrosis Factor Receptor;Tumor-associated macrophages;vector;Virus

PROJECT_TITLE: Phage-based therapeutic gene delivery targeting multiple compartments in solid tumors


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza

ORG_CITY: TYLER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH CTR AT TYLER

ORG_STATE: TX

PHR: Project Narrative: Successful completion of this proposal will reveal a novel role of Runx3 in mediating lung cDC2-driven priming and activation of non-Th1 CD4+ T cell subsets during influenza infection. The proposed studies will enable us to identify novel factors and pathways that prevent optimal immunity against respiratory viral infection. The proposal will lead to a comprehensive understanding of Runx3 regulation of T cell immunity during respiratory viral infection.

PI_NAMEs: TANG, HUA  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Affect;age group;Alveolar Macrophages;antiviral immunity;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Differentiation process;Cells;Colon;Compensation;cytokine;cytotoxic;cytotoxic CD8 T cells;Data;Defense Mechanisms;Dendritic Cells;Development;Double-Stranded RNA;Economics;Embryonic Development;Equilibrium;genetic approach;Health;Human;Immune;Immune response;Immunity;Immunomodulators;Inflammatory;Influenza;Influenza A virus;influenza infection;Innate Immune Response;ITGAX gene;Knock-out;Knockout Mice;Lung;Mediastinal lymph node group;Mediating;migration;Modeling;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;Neoplasms;novel;Outcome;Pathway interactions;Play;prevent;Production;Prognosis;Proliferating;Regulation;Regulatory T-Lymphocyte;Reporting;Resistance;respiratory virus;response;Role;RUNX3 gene;SARS-CoV-2 infection;Signal Transduction;survival outcome;T cell regulation;T cell response;T-Lymphocyte Subsets;Testing;Tissues;transcription factor;Viral;Viral Respiratory Tract Infection;Virus;Virus Diseases;Virus Replication;World Health

PROJECT_TITLE: Role of Runx3 in the Regulation of Lung cDC2 by Influenza Infection


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: HAMPTON

ORG_DEPT: BIOLOGY

ORG_NAME: HAMPTON UNIVERSITY

PHR: PROJECT NARRATIVE  African American students are under-represented in genome sciences, in part, because of a lack of opportunities exposing them to research methodologies and related careers. The proposed program will expose under-represented students at Hampton University (an HBCU) to a broadly themed series of genome sciences activities aimed at: (1) enhancing computations skills relevant to human diseases, (2) increasing laboratory research experiences translatable to biomedical sciences, and (3) improving training platforms in data analysis, interpretation, and dissemination. Comparative genomic analyses of vertebrate genomes will be used as a framework for bone cell evolution/biology, cell culture methods will reinforce the potential for manipulating the behavior of bone forming cells, and integrated analysis of next-generation sequencing data will allow first-hand exposure to the entire process of scientific inquiry toward the overarching goal of placing our students into post- graduate programs that develop into productive genome sciences careers.

PI_NAMEs: LEWALLEN, ERIC ALEXANDER (contact)

PROGRAM_OFFICER_NAME: HERNANDEZ-RAMON, ELENA ESTELA

PROJECT_TERMS: Academic skills;Academic support;Advisory Committees;African American;African American population;African American student;Antioxidants;Beaked Whales;Behavior;Bioethics;Bioinformatics;Biological;Biology;biomineralization;biosecurity;bone;bone cell;Bone Development;Bone Diseases;Bone Tissue;career;career development;Caring;Cell Culture Techniques;Cells;Cellular biology;Centrarchidae;clinical care;Communication;comparative;Comparative Genomic Analysis;comparative genomics;Competence;Complement;Computing Methodologies;Conflict of Interest;Core Facility;Curiosities;Data;Data Analyses;Data Collection;Dedications;demographics;dietary supplements;Disparity;Education;education planning;education research;Employment;Environmental Microbiology;Epigenetic Process;epigenomics;equity, diversity, and inclusion;Evaluation;Evolution;experience;experimental study;Exposure to;Faculty;faculty mentor;falls;Fostering;Future;Genes;Genetic;Genome;genome sciences;genomic data;genomic tools;Genomics;Goals;Good Clinical Practice;Gorilla gorilla;Hagfish;Halo Effects;hands on research;Health;health disparity;Historically Black Colleges and Universities;Homeostasis;Human;human disease;Human Subject Research;improved;In Vitro;innovation;Institution;Investigation;Laboratory Research;Link;Mammals;marine;member;Mentors;Mesenchymal Stem Cells;Metabolism;Methods;methylomics;mineralization;Mission;Modeling;Molecular;Monitor;Morphology;Multiomic Data;Musculoskeletal;National Human Genome Research Institute;Natural regeneration;next generation sequencing;Nutrient;Oceans;Odobenus rosmarus;Organism;Osteogenesis;Participant;Peer Review;Petromyzon marinus;Phenotype;Physiological;Phytochemical;Privacy;Process;Productivity;programs;Publications;recruit;Recruitment Activity;Regulatory Element;Regulatory Pathway;repaired;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Training;response;responsible research conduct;Science;Scientific Inquiry;Security;Series;skeletal;skeletal disorder;Skeleton;skill acquisition;skills;skills training;stem cells;STEM field;student participation;student training;Students;summer program;Surveys;symposium;Taxonomy;Techniques;Tissues;Training;Training and Education;transcriptomics;trend;undergraduate student;Underrepresented Students;Universities;Vermont;vertebrate genome;Vertebrates;Virginia;virtual;volunteer;web portal

PROJECT_TITLE: Enhancing Diversity in Genomics Education and Research (EDGER)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (M3)]


NIH_SPENDING_CATS: Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative This project focuses on the role of neuronal activity in regulating the timing of oligodendrocyte progenitor cell differentiation. While extensive literature indicates that increased neuronal activity increases oligodendrocyte progenitor cell differentiation and myelination, the current studies establish that in early brain development, neuronal activity blocks differentiation. The current studies investigate how this difference is regulated and when in development there is a transition from neuronal activity blocking oligodendrocyte progenitor cell differentiation to neuronal activity enhancing differentiation.

PI_NAMEs: MACKLIN, WENDY B (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Axon;Brain;Cell Communication;Cell Maturation;Central Nervous System;Clozapine;Corpus Callosum;Data;Designer Drugs;designer receptors exclusively activated by designer drugs;Development;experimental study;Gene Expression;Genetic Transcription;in vivo;Inhibition of Cell Proliferation;Investigation;Literature;Modeling;Morphology;Mus;myelination;neuron development;Neuronal Differentiation;neuronal excitability;Neurons;neurotransmission;novel;oligodendrocyte progenitor;Oligodendroglia;Oxides;Perinatal;premature;programs;pup;response;Role;Sampling;single-cell RNA sequencing;Stem Cell Development;stem cell differentiation;stem cell genes;stem cell proliferation;stem cells;System;Time;transcriptome

PROJECT_TITLE: Axonal signaling regulating oligodendrocyte differentiation

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Pediatric;Recovery Support Services;Rural Health;Social Determinants of Health;Substance Misuse;Violence Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative Family peer mentors are peer supporters with lived substance use disorder recovery and child welfare histories who help parents navigate substance use disorder and child welfare systems. They are critical for delivering interventions that connect parents to treatment but often leave their position after feeling unsupported and stigmatized within child welfare agencies which stops implementation. This proposed study will examine the impacts and build infrastructure to scale-up CrOss Systems Technical Assistance for Retaining Staff (COSTARS) – an innovative supervision coaching model for child welfare supervisors designed to improve supportive supervision, reduce stigma in child welfare agencies, and retain staff which will lead to stronger implementation and parent outcomes.

PI_NAMEs: BUNGER, ALICIA C (contact);SALDANA, LISA

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: abuse neglect;Acceleration;Address;Adopted;Appalachian Region;Child;Child Abuse and Neglect;child services;Child Welfare;Climate;Collaborations;Communities;comparison group;Competence;Contracts;County;Data;Death Rate;design;effective intervention;Effectiveness;effectiveness testing;effectiveness/implementation study;Epidemic;evidence base;Evidence based intervention;expectation;experience;Family;family support;Feedback;Feeling;Goals;Helping to End Addiction Long-term;Hybrids;implementation fidelity;implementation trial;improved;Infrastructure;innovation;Intention;Intervention;Leadership;Manuals;Measures;medication-assisted treatment;member;Modeling;Monitor;Needs Assessment;Occupations;Ohio;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;Outcome;Overdose;overdose death;Parents;peer;peer coaching;Perception;Persons;Phase;Positioning Attribute;prevent;professional atmosphere;programs;Public Health;Randomized;Recording of previous events;Records;Recovery;Reporting;Research;research to practice;Resources;response;Risk;Rural;satisfaction;scale up;Series;service delivery;Services;sobriety;social stigma;Speed;staff intervention;Stigmatization;Stress;substance use;Substance Use Disorder;Supervision;Surveys;System;Testing;theories;therapy design;Training;Translational Research;treatment disparity;trial design;United States National Institutes of Health;virtual;Work

PROJECT_TITLE: Staffing and Supports for Implementing Cross-System Interventions with Peer Mentors

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKP-E (M2)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Post-Traumatic Stress Disorder (PTSD);Prevention;Substance Misuse;Telehealth

ORG_CITY: KINGSTON

ORG_NAME: UNIVERSITY OF RHODE ISLAND

PHR: PROJECT NARRATIVE Community re-entry is disorder following residential opioid use disorder (OUD) treatment is a critically vulnerable time that characterized by high rates of return to use, particularly for individuals with co-morbid posttraumatic stress (PTSD). This proposal willuse a ground-up approach to rigorously develop and evaluate a mobile app with both on-demand (24/7 PTSD-OUD resources) and automated (skills-based PTSD-OUD interventions) features to reduce opioid use/harms during community re-entry of adults with co-morbid PTSD-OUD. Our final productwill be a highly scalable mobile app that has strong potential to improve health and quality of life.

PI_NAMEs: WEISS, NICOLE HOLLAND (contact)

PROJECT_TERMS: adaptive intervention;Address;Adult;Awareness;Caring;Cessation of life;Clinical;Communities;community reentry;comorbidity;cost effective;Data;design;Development;Disease;dosage;Ecological momentary assessment;effective therapy;efficacy evaluation;efficacy testing;Ensure;Epidemic;Equity;Evaluation;evidence base;Experimental Designs;follow-up;Goals;Health;Health Services Accessibility;high risk;Hybrids;implementation outcomes;improved;improved outcome;Individual;innovation;Inpatients;Intervention;Interview;Link;marginalized population;Methodology;mHealth;mhealth interventions;mobile application;Opioid;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose reduction;Patients;Persons;post-traumatic stress;Post-Traumatic Stress Disorders;Prediction of Response to Therapy;prevent;primary outcome;Process;programs;Provider;Quality of life;Randomized;randomized trial;Research Methodology;Residential Treatment;Resources;response;return to use;Risk;Risk Reduction;secondary outcome;Services;Severities;skills;social;sound;Standardization;Stress;substance use;substance use treatment;support tools;Symptoms;Testing;Time;tool;Trauma;treatment as usual;trial design

PROJECT_TITLE: Development and Evaluation of a Mobile Health Intervention for Co-Morbid Opioid Use Disorder and Posttraumatic Stress Disorder During Community Re-entry


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: Project Narrative: Rutgers University-New Brunswick is requesting funds to convert fourteen IVC racks to a smart artificial intelligence (AI) enabled system to monitor the animals and fourteen environmental monitoring (REM) devices to monitor the macroenvironment of the animal housing rooms. This novel digital ventilated caging (DVC) will enable continuous (24 x7) monitoring of animals in their home cage, help detect early clinical signs of disease or discomfort in animals, prevent human errors such as missed low food or lack of water bottles in the cages, identify soiled bedding using a digital biomarker-bedding status index, increase operational efficiency, and improve animal welfare. The REM devices will help facility management monitor extrinsic variables for research such as noise, light, temperature, humidity, vibration and correct the variables in a timely manner to improve reproducibility of research results.

PI_NAMEs: ESWARAKA, JEETENDRA REDDY (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: Affect;animal care;animal facility;Animal Housing;Animal Husbandry;Animal Welfare;Animals;Artificial Intelligence;Arts;Beds;Cavia;Censuses;Clinical;Communication;Computer software;Decision Making;Detection;digital;Digital biomarker;digital monitoring;digital technology;Disease;Early Diagnosis;Engineering;Environmental Monitoring;environmental monitoring device;Faculty;Floods;Food;Funding;Gerbils;Health;Home;Human;human error;Human Genetics;humane endpoint;Humidity;improved;indexing;Individual;Intervention;Light;Lighting;Location;Machine Learning;Magnetism;mid-career faculty;Monitor;Movement;multidisciplinary;Mus;Neurosciences;New Brunswick;New Jersey;Noise;novel;operation;Oryctolagus cuniculus;Outcomes Research;Pattern;Personnel Management;Pharmacy Schools;prevent;Psychology;Publishing;Rattus;Reader;Reproducibility;Research;Rodent;sample collection;Savings;Schools;Science;sensor;Soil;square foot;System;Technology;Temperature;Time;Tissues;Universities;ventilation;vibration;Water;welfare

PROJECT_TITLE: Harnessing the power of digital caging and artificial intelligence (AI) to improve animal welfare and husbandry operations at Rutgers University-New Brunswick

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-U (91)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Dementia;Hypertension;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: AUGUSTA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

PHR: We will test the novel hypothesis that the combined presence of increased blood pressure variability (before hypertension), and a high salt diet, accelerates the onset of hypertension and cognitive decline. Specifically, the study will elucidate how multiple risks factors drive cognitive decline through damage to the cerebral microcirculation.

PI_NAMEs: FILOSA, JESSICA A (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Acceleration;Animal Model;Blood - brain barrier anatomy;Blood Pressure;blood pressure elevation;blood pressure variability;Brain;Cause of Death;Cerebrum;cognitive function;Dementia;dementia risk;Dependence;disability;early onset;Goals;high risk;high salt diet;Human;Hypertension;Impaired cognition;Individual;Microcirculation;middle age;mouse model;Nerve Degeneration;neurovascular;Normal Range;novel;old mice;older adult;Output;Perfusion;Risk Factors;Testing

PROJECT_TITLE: The impact of blood pressure variability on neurovascular function (Diversity Supplement)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(91)]


NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Health Services;Pain Research;Primary Health Care;Rehabilitation;Substance Misuse

ORG_CITY: Provo

ORG_NAME: AXCEND, LLC

ORG_STATE: UT

PHR: Project Narrative This I-Corps project focuses on the identification of the most important markets and use cases for a compact capillary liquid chromatograph platform that is under development in our predicate Phase I project that fills a critical need for monitoring illicit drug use in drug treatment facilities and pain clinics. Participation in I-Corps will help Axcend identify improvements that should be made in our analytical platform early on to best perform this type of testing in point-of-care settings and how to best approach the most promising near-term markets.

PI_NAMEs: LEE, MILTON L. (contact)

PROGRAM_OFFICER_NAME: NGUYEN, TAM L

PROJECT_TERMS: Address;Blood capillaries;Businesses;capillary liquid chromatography;cohort;Development;Devices;drug of abuse;drug rehabilitation;Drug Rehabilitation Centers;Drug usage;effective therapy;Financial Support;Goals;Grant;Health care facility;Healthcare Industry;illicit drug use;improved;Innovation Corps;instructor;instrument;Interview;Liquid Chromatography;Liquid substance;Marketing;member;Modification;Monitor;Motivation;Pain Clinics;patient screening;Patients;Pharmacotherapy;Phase;point of care;Preparation;programs;routine screening;Sampling;Small Business Innovation Research Grant;Specificity;Suggestion;Technology;Testing;Time;Urine

PROJECT_TITLE: Compact Liquid Chromatography for Routine Screening in Drug Treatment Centers


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Microbiome;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE This project will conduct prospective cross-sectional and longitudinal studies to assess the overarching hypothesis that disruptions in the Gut-Microbiota-Brain-Axis (GMBA) contribute to PD pathogenesis. We posit that a comprehensive model, incorporating validated clinical measures and pathophysiological markers of GMBA disruption, will predict disease severity (Aim 1) and progression (Aim 2) and onset (Aim 3). Outcomes from this project will shed light on mechanisms underpinning PD, identify new therapeutic targets / approaches, and the totality of this project in combination with the collective efforts and resources of others in the NIDDK Consortium is expected to vertically shift the field.

PI_NAMEs: GOETZ, CHRISTOPHER G.;KESHAVARZIAN, ALI  (contact);SHARMA, AMOL

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Age;alpha synuclein;Animal Model;biological age;Biological Aging;Biological Markers;Biopsy;Blood;Body mass index;Brain;Central Nervous System;Characteristics;Classification;Clinical;clinical phenotype;cohort;Collaborations;Data;Disease;Disease Progression;dysbiosis;Elements;Feces;Functional disorder;Functional Magnetic Resonance Imaging;Gastroenterology;Gender;gut microbiota;Household;Image;Inflammaging;Inflammation;Infrastructure;insight;Institution;intestinal barrier;Light;Longitudinal Studies;Measures;medical schools;member;Metadata;microbiota;microbiota-gut-brain axis;Modeling;Movement Disorder Society Unified Parkinson's Disease Rating Scale;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;Nerve Degeneration;neurofilament;Neurologist;Neurology;new therapeutic target;Nose;novel;novel therapeutic intervention;Outcome;Parkinson Disease;Pathogenesis;Pathology;Patients;Pattern;personalized therapeutic;Pharmaceutical Preparations;Phase;Population Control;Prognosis;programs;prospective;Questionnaires;Race;recruit;repository;Research;resilience;Resources;Sampling;Science;Serum;Severities;Severity of illness;Sigmoid colon;Sigmoidoscopy;Symptoms;synucleinopathy;Testing;Tissues;Universities;Validation;Visit

PROJECT_TITLE: The Bidirectional Gut-Microbiota-Brain Axis in Parkinson’s disease: integrating mechanistic biomarkers of disease severity and progression

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-C (M2)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative The veridical representation of odor information in the olfactory cortex is challenged by behavioral signals and representational drift. Using in vivo two-photon microscopy, behavioral monitoring and closed-loop manipulations, we seek to understand the functional role of behavioral signals in odor processing. Completion of this study will open up new avenues of inquiry into the selective manipulation of neural circuit components underlying olfactory sensory-motor transformations during active sensing.

PI_NAMEs: FLEISCHMANN, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Anatomy;Animal Behavior;Area;Behavior;Behavior monitoring;behavior prediction;Behavioral;Biological Models;Brain region;Calcium;Chronic;Code;Cognitive;Complex;Computer Models;Coupled;Coupling;Data;Environment;Exhibits;Experimental Designs;Exposure to;Face;Foundations;Future;Generations;Head;Image;in vivo;insight;Investigation;Linear Models;Locomotion;Methodology;Modality;Modeling;Motor;Movement;Mus;Nervous System Physiology;neural;neural circuit;Neurons;Neurosciences;Odors;olfactory bulb;Olfactory Cortex;Olfactory Pathways;Perception;Peripheral;piriform cortex;Positioning Attribute;Process;Property;receptor;Reproduction;response;Role;Sensory;sensory cortex;sensory input;sensory stimulus;Shapes;Signal Transduction;Smell Perception;System;Testing;Time;two photon microscopy;two-photon

PROJECT_TITLE: Convergence of behavioral and sensory information in olfactory cortex

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Autism;Brain Disorders;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SANTA CRUZ

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

ORG_STATE: CA

PHR: PROJECT NARRATIVE Localized de novo protein synthesis mediates cellular plasticity but is poorly understood due to a paucity of methods. This research project focuses on leveraging novel cryogenic electron microscopy methods to understand how fragile X mental retardation protein, a key protein whose absence causes the most prevalent form of autism spectrum disorder, silences translation in two types of cellular RNA granules.

PI_NAMEs: LOERCH, SARAH  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Address;Affect;autism spectrum disorder;Auxins;Back;Binding;Cell Line;Cells;Central Nervous System;chronic pain;Consensus;Cryoelectron Microscopy;Cytoplasmic Granules;Data;Disease;disease model;Dissociation;Event;field study;Fluorescence;Fluorescence Microscopy;FMR1 gene;Foundations;Fragile X Syndrome;FXR2 gene;gene product;Heritability;human disease;human induced pluripotent stem cells;improved;In Situ;Individual;induced pluripotent stem cell;inhibitor;innovation;insight;interest;Investigation;Knowledge;Label;Link;Location;long term memory;Maintenance;Major Depressive Disorder;Mediating;Memory;Memory impairment;Messenger RNA;Methods;microscopic imaging;Mission;model of autism spectrum disorder;Modeling;Molecular;National Institute of Neurological Disorders and Stroke;Nature;Nervous System Disorder;Neurites;Neurodevelopmental Disorder;neuron development;Neuronal Plasticity;Neurons;Neurotransmitters;novel;Pathology;patient derived induced pluripotent stem cells;Phase;Physiological;Play;pleiotropism;Polyribosomes;preservation;prevent;Process;Protein Biosynthesis;Proteins;Protocols documentation;PURA gene;Regulation;Research Project Grants;Resolution;response;Ribosomal Proteins;Ribosome Inactivation;Ribosomes;RNA;Role;Saccharomyces cerevisiae;Sensitivity and Specificity;stem cell model;Stimulus;Structure;Synapses;Synaptic plasticity;Techniques;translation to humans;translational model;Translational Regulation;Translations;Work

PROJECT_TITLE: Localized translational dysregulation in an autism spectrum disorder model using in situ cryo-EM

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ORG_CITY: RICHMOND

ORG_DEPT: ADMINISTRATION

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: PROJECT NARRATIVE This proposal aims to develop and assess the effects of exposure to novel educational messages focused on correcting misperceptions about the continuum of health risks for nicotine delivered in combustible versus non- combustible products, specifically among socioeconomically disadvantaged adults who smoke cigarettes. Increasing continuum of risk knowledge among smokers at disparate risk for heavy smoking and resulting health consequences is timely and relevant to public health priorities in the field of tobacco regulatory science and will inform future research regarding use of public education to reduce the health consequences of smoking.

PI_NAMEs: SNELL, L MORGAN (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Adult;Advertising;Area;Behavior;behavior change;Cigarette;cigarette smoke;Clinical Trials;Clinical Trials Design;combustible cigarette;Communication;comparison control;Complex;Decision Making;design;Development;Disease;Disparate;econometrics;Education;educationally disadvantaged;Effectiveness;effectiveness evaluation;Electronic cigarette;Ensure;Environment;Exposure to;Face;Future;General Population;Goals;Harm Reduction;Health;health communication;high risk;Incentives;intervention effect;Interview;Knowledge;Lead;Leadership;low socioeconomic status;Mechanics;Medicine;Mentors;Methodology;Morbidity - disease rate;mortality;Nicotine;nicotine use;novel;Participant;Perception;Persons;Phase;Policies;Population;Population Study;programs;public education;public health priorities;Qualitative Methods;Qualitative Research;Randomized;Randomized, Controlled Trials;recruit;Relative Risks;Research;Research Methodology;Risk;risk perception;Series;Smoke;Smoker;Smoking;smoking cessation;socioeconomic disadvantage;Statistical Methods;substance use;success;Testing;Tobacco;tobacco advertising;tobacco control;tobacco products;tobacco regulatory science;Tobacco use;Tobacco Use Cessation;Training;Universities;Virginia;Vulnerable Populations

PROJECT_TITLE: Development and Assessment of Nicotine Continuum of Risk Education on Tobacco Use Among Socioeconomically Disadvantaged Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-Q (50)]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease caused by the loss of upper and lower motor neurons, leading to progressive muscle weakness and paralysis. This project aims to determine whether motor cortex hyperexcitability, an early clinical abnormality, drives the disease and the underlying cell-specific molecular mechanisms.

PI_NAMEs: JIANG, JIE  (contact);QIN, ZHAOHUI

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: ALS patients;Amyotrophic Lateral Sclerosis;Behavioral;Cells;Cessation of life;Clinical;Clinical Trials;Disease;DNA Sequence Alteration;Enhancers;experience;Functional disorder;Genetic;Human;insight;Intervention;Molecular;Motor Cortex;Motor Neurons;Mus;Muscle;Muscle Cramp;Muscle fasciculation;Muscle Weakness;Mutation;neural;Neurodegenerative Disorders;neuron loss;Neurons;neurophysiology;Paralysed;parent grant;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Play;Rodent Model;Role;superoxide dismutase 1;Therapeutic Intervention;therapeutic target;tool;Transgenic Mice;Viral

PROJECT_TITLE: Mechanistic insights of cortical hyperexcitability in ALS


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: The proposed research is relevant to the public health because characterizing the roles of protein kinases in Candida glabrata drug resistance mechanism represents ways in which C. glabrata kinase activity might be therapeutically targeted to overcome antifungal resistance. Therefore, this research is relevant to the National Institute of Allergy and Infectious Diseases’ mission that pertains to supporting basic and applied research to better understand, treat, and ultimately prevent infectious diseases, particularly regarding the emphasis area of antimicrobial resistance.

PI_NAMEs: VU, BAO GIA (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Amphotericin B;anti-fungal agents;Antifungal Therapy;Antimicrobial Resistance;Applied Research;Area;Auxins;Azoles;Bar Codes;Basic Science;Biological Assay;Biology;calcineurin phosphatase;Candida;Candida glabrata;Catalytic Domain;Characteristics;Clinical;Clinical Trials;Communicable Diseases;Communities;CRISPR/Cas technology;Data;deletion library;Development;Disseminated candidiasis;drug development;Drug resistance;drug sensitivity;Drug Targeting;Drug Tolerance;Exhibits;fitness;Fluconazole;Frequencies;Fungal Drug Resistance;Future;Gene Expression Profiling;Genetic;genetic analysis;genetic resource;genome-wide;Genomics;Goals;human pathogen;In Vitro;in vivo;Infection;innovation;insight;kinase inhibitor;Knowledge;Libraries;Link;Medicine;Metabolism;Minimum Inhibitory Concentration measurement;Mission;Multi-Drug Resistance;mutant;National Institute of Allergy and Infectious Disease;novel;pathogenic fungus;Pathway Analysis;Pharmaceutical Preparations;Pharmacotherapy;Phosphorylation;Phosphotransferases;Polyenes;Predisposition;preservation;prevent;Protein Analysis;Protein Dephosphorylation;Protein Dynamics;protein function;Protein Kinase;Proteins;Public Health;Regulation;Research;Resistance;resistance mechanism;Resistance profile;Role;Saccharomyces cerevisiae;System;Testing;therapeutic target;Time;transcription factor;transcriptome;transcriptome sequencing;Triazoles;Work;Yeasts

PROJECT_TITLE: Functional and transcriptome analyses of protein kinases in Candida glabrata antifungal drug resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(82)]