NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Palliative Care;Patient Safety;Precision Medicine;Prevention;Telehealth;Women's Health Research

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE New oral chemotherapy treatments, such as cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) for women with metastatic breast cancer double progression-free survival and increases overall survival. Our study will test a new mobile health intervention that facilitates remote monitoring and patient-provider communication outside of clinic visits regarding the use of the medication among 390 English- and Spanish- speaking patients treated at community oncology practices across the country. We will use a mixed-methods approach to evaluate the impact of the intervention on a comprehensive set of outcomes, including rigorous measures of adherence and key patient-reported outcomes, such as symptom burden, quality of life, and survival.

PI_NAMEs: GRAETZ, ILANA ;SADIGH, GELAREH  (contact)

PROGRAM_OFFICER_NAME: CASTRO, KATHLEEN M

PROJECT_TERMS: Address;Adherence;adherence rate;adjuvant endocrine therapy;Adult women;Advocate;Age;arm;automated text message;breast cancer diagnosis;cancer therapy;CDK4 gene;Cellular Phone;chemotherapy;Clinic Visits;Clinical;Communication;Community Clinical Oncology Program;Complex;cost;Country;Data;Dependence;dosage;Dose;Educational Materials;Electronic Mail;Emergency department visit;Enrollment;Epidermal Growth Factor Receptor;experience;Foundations;Frequencies;Goals;Health;health care service utilization;Healthcare;healthcare community;hormone receptor-positive;hormone therapy;Hospitalization;Human;improved;Incidence;individualized medicine;Inequity;inhibitor;innovation;Intervention;Interview;Lead;Malignant Breast Neoplasm;Measures;medication compliance;member;Metastatic breast cancer;Methods;mHealth;mhealth interventions;Monitor;Notification;novel;older women;Oncology;Oral;Outcome;Participant;participant enrollment;patient engagement;Patient Outcomes Assessments;patient-clinician communication;Patients;Penetration;Pharmaceutical Preparations;Population;Population Heterogeneity;primary endpoint;programs;Progression-Free Survivals;Provider;Publishing;Quality of life;Race;Randomized, Controlled Trials;Recording of previous events;recruit;Regimen;remote monitoring;Reporting;Research;satisfaction;Schedule;Self Efficacy;side effect;Signal Transduction;Spanish;Spanish/English;Surveys;Symptom Burden;symptom management;symptomatic improvement;Symptoms;System;Technology;Telemedicine;Testing;Text;Text Messaging;Time;Training;treatment as usual;Underserved Population;usability;usual care arm;Visit;web portal;Woman;young woman

PROJECT_TITLE: Improving medication adherence using a CONnected CUstomized Treatment Platform (CONCURxP)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-T(02)]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: CORVALLIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The overarching goal of our research program is to understand how epithelial barriers such as skin, lung, and oral surfaces change with age, inflammation, and hormonal signaling. Understanding the underlying biological processes and mechanisms that affect these barriers will help us develop tools for disease diagnosis, treatment, and prevention.

PI_NAMEs: FOGG, KAITLIN C (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: absorption;Address;Affect;Age;age related changes;Binding;Biological Availability;Biological Process;Cell Polarity;Cell Proliferation;Chemicals;Circulation;Collection;Complex;computerized tools;Cues;Data Set;design;Disease;disease diagnosis;Drug Delivery Systems;Drug Transport;ECM receptor;Epithelium;Extracellular Matrix;Extracellular Matrix Proteins;fibrous protein;Genes;Goals;hormonal signals;Human;Image Analysis;Immune;In Vitro;in vitro Model;Individual;Inflammation;Kinetics;Knowledge;Libraries;Localized Disease;Lung;Machine Learning;Maintenance;Mechanics;Menstrual cycle;Methods;migration;Modeling;Molecular;Morphology;novel;novel therapeutics;Oral;Organ;Permeability;Pharmaceutical Preparations;Phase;Prevention;programs;Proteins;Proteome;Research;Role;Signal Transduction;Site;Skin;Statistical Models;Stratified Epithelium;Surface;Systemic disease;Systems Biology;Techniques;three-dimensional modeling;Tissue Engineering;Tissues;tool

PROJECT_TITLE: The epithelial matrisome and drug transport kinetics


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Social Determinants of Health;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative The overarching goal of our proposed project is to address health inequities in breast cancer screening follow- up among underserved women. We will test whether a community services navigation intervention for women with abnormal results after routine screening mammogram improves follow-up. Outreach to underserved women, who represent a large proportion of late-stage and higher mortality breast cancers, will result in improved follow-up to breast screening leading to improved breast cancer outcomes and decreased health disparities.

PI_NAMEs: ONEGA, TRACY ;OZANNE, ELISSA MARY (contact)

PROGRAM_OFFICER_NAME: SARMA, ELIZABETH ANNE

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Address;Breast Cancer Detection;breast imaging;Cancer Control;cancer health disparity;cancer prevention;care episode;Caring;Cervical Cancer Screening;Clinical Trials;community engagement;Community Services;Death Rate;disadvantaged women;Disease;Disparity;economic disparity;effectiveness evaluation;Equity;evidence base;experience;falls;follow-up;Food;Goals;Grant;health disparity;health equity;health equity promotion;health inequalities;health information technology;Health Promotion;Housing;implementation intervention;improved;improved outcome;Inequity;interest;Intervention;life span;Malignant Breast Neoplasm;Mammographic screening;Mammography;Methods;mortality;Outcome;outreach;Participant;patient screening;Patient Self-Report;Patients;point of care;Population Heterogeneity;preventable death;Preventive care;Preventive service;Process;programs;Randomized, Controlled Trials;Recommendation;Reduce health disparities;referral services;remediation;Resources;Role;routine screening;screening;screening program;Screening Result;service providers;Services;social;social disparities;social health determinants;Social Work;Testing;Time;Transportation;treatment as usual;United States Preventative Services Task Force;uptake;Visit;Woman;Work;World Health Organization

PROJECT_TITLE: Community Services Navigation to Advance Health Equity in Breast Cancer Screening

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cancer;Digestive Diseases;Esophageal Cancer;Genetics;Prevention;Rare Diseases;Substance Misuse;Substance Misuse Prevention

ORG_CITY: CAMDEN

ORG_NAME: CORIELL INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NJ

PHR: NARRATIVE  Alcohol drinking is a known risk factor of esophageal diseases, e.g., gastroesophageal reflux disease (GERD) and esophageal squamous cell carcinoma (ESCC). Using cultured cells and animal models, we will characterize the role of NRF2-ACSS2 axis in mediating alcohol-induced metabolic reprogramming in human esophageal squamous epithelial cells and the mouse esophagus. If successful, this work will lay down a solid mechanistic foundation for NRF2/ACSS2 inhibition as a novel mechanism-based prevention for alcohol-associated esophageal pathology.

PI_NAMEs: CHEN, XIAOXIN LUKE (contact);ZHANG, GUOFANG

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Acetaldehyde;Acetates;Acetyl Coenzyme A;Alcohol consumption;alcohol exposure;alcohol prevention;Alcohols;Animal Model;Autoradiography;Biological Assay;cancer cell;Carbon;Carcinogens;Cell model;Cell Proliferation;Cells;Citric Acid Cycle;Clinical;Coenzyme A Ligases;Cultured Cells;Data;density;design;Diet;DNA;Dose;Drug Metabolic Detoxication;Epithelial Cells;Esophageal Diseases;Esophageal Squamous Cell;Esophageal Squamous Cell Carcinoma;Esophagus;Ethanol;Ethanol Metabolism;Family member;Foundations;Future;Gastroesophageal reflux disease;Gene Expression;Gene Modified;Genes;Genetic Transcription;Genus Hippocampus;Histone Acetylation;Human;Hyperactivity;In Vitro;in vivo;inhibitor;knock-down;Label;Link;lipid biosynthesis;Lipids;Liquid substance;Malignant neoplasm of esophagus;Malignant Neoplasms;Measures;Mediating;Membrane Transport Proteins;Metabolic;Metabolism;metabolomics;Modeling;Molecular;Mus;Neoplasm Metastasis;novel;nuclear factor-erythroid 2;Pathology;PET/CT scan;Phase;Phenotype;Preventive;Preventive measure;Production;Proteins;Regulation;Risk Factors;Role;Signal Transduction;Solid;Source;stable isotope;Testing;Time;Tissues;transcription factor;Translating;tumor progression;uptake;Work

PROJECT_TITLE: NRF2-ACSS2 Axis in Alcohol-induced Metabolic Reprogramming and Esophageal Pathology

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Brain Disorders;Burden of Illness;Cardiovascular;Cerebrovascular;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Hematology;Prevention;Social Determinants of Health;Stroke;Telehealth

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Public Health Relevance Quantifying disruptions in care and outcomes for non-COVID related disease is necessary for understanding the full impact of the COVID-19 pandemic on health care utilization and outcomes. We will measure the effects of the pandemic on diagnosis, therapy initiation, therapy adherence, monitoring, and health outcomes for patients with atrial fibrillation, a cardiovascular disease that affects over 5 million individuals in the US and quintuples the risk of stroke. Our findings will have major implications for the development of clinical guidance and policies that lessen disruptions in chronic disease care and prevent adverse outcomes in future crises.

PI_NAMEs: PATEL, NIMISH  (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Adherence;adverse outcome;Affect;Age;age difference;Anticoagulants;Anticoagulation;Area;Arrhythmia;Atrial Fibrillation;beneficiary;Blood Tests;Cardiac;Cardiovascular Diseases;Cardiovascular system;Caring;Cessation of life;Chronic Disease;Clinical;clinical development;cost;County;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;Data;deprivation;Diagnosis;Disease;Disparity;Electronic Health Record;Emergency response;Emergency Situation;Ethnic Origin;Event;Fee-for-Service Plans;Future;Goals;Health;health care service utilization;health disparity;Hemorrhage;Hospitalization;Incidence;Individual;International Normalized Ratio;Interruption;Laboratories;Link;Measures;Medical Records;Medicare;Minority;Modeling;Modification;Monitor;Newly Diagnosed;Oral;Outcome;pandemic disease;pandemic disruption;pandemic impact;Patient-Focused Outcomes;Patients;Persons;Policies;Population;pre-pandemic;prevent;Prevention therapy;Prognosis;public health relevance;Race;Reporting;Risk;Role;segregation;sex;social;Socioeconomic Status;Stroke;stroke incidence;Stroke prevention;stroke risk;Structural Models;telehealth;Telemedicine;Testing;Therapeutic;therapy adherence;Time;Time Series Analysis;United States National Institutes of Health;uptake;urban area;Urbanization;Visit;Vulnerable Populations;Warfarin

PROJECT_TITLE: Pandemic Disruptions of Atrial Fibrillation Care

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Project Narrative Pancreatic cancer is a devastating disease largely because it is diagnosed at a late stage when metastasis has already occurred. Our research has shown that pancreatic cancers change over time. The goal of this proposal is to determine the extent that these changes, known as subclonal evolution, can be quantified for clinical benefit and to guide therapeutic management.

PI_NAMEs: IACOBUZIO-DONAHUE, CHRISTINE A (contact)

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: Address;Biology;BRCA2 Mutation;Cancer Biology;Cancer Etiology;Cells;Cessation of life;Clinical;Clinical Management;clinically relevant;Common Neoplasm;Computer Models;Diagnosis;Disease;Evolution;Excision;exome;experimental study;Genetic;Genetic Transcription;Genome;Goals;Heterogeneity;Immune checkpoint inhibitor;innovation;interest;Malignant neoplasm of pancreas;Malignant Neoplasms;Mismatch Repair Deficiency;mouse model;Neoplasm Metastasis;novel strategies;Operative Surgical Procedures;pancreatic neoplasm;PARP inhibition;Patients;Platinum;Recurrence;Research;Salts;Sampling;single cell technology;statistics;Therapeutic;Time;Tissues;tumor;tumor heterogeneity;United States;whole genome;Work

PROJECT_TITLE: Interrogating the Evolutionary Dynamics of Cancer for Clinical Benefit and Actionability


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Infant Mortality;Lung;Neonatal Respiratory Distress;Neurosciences;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Pulmonary Hypertension;Rare Diseases;Stroke;Unintentional Childhood Injury

ORG_CITY: DAVIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative: Whole body cooling has improved brain outcomes following birth asphyxia but can reduce blood flow to the lungs and lower oxygen levels. This study evaluates optimal oxygen level and medications such as nitric oxide and sildenafil to improve both lung and brain outcomes following birth asphyxia.

PI_NAMEs: LAKSHMINRUSIMHA, SATYANARAYANA  (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: 3-nitrotyrosine;Accounting;Animal Model;Antioxidants;Apoptotic;arm;Asphyxia Neonatorum;Blood flow;Brain;Brain Injuries;California;Canada;cerebral hemodynamics;Cerebrum;Cessation of life;Childhood;Clinical Trials;Data;design;Drug Kinetics;Duct (organ) structure;Electroencephalography;European;Exposure to;Extracorporeal Membrane Oxygenation;Future;Gases;Goals;hemodynamics;Hippocampus;Hour;Hypoxanthines;Hypoxemic Respiratory Failure;Impairment;improved;Incidence;indexing;Infant;inhaled nitric oxide;Intravenous;lamb model;Lung;Meconium Aspiration;Mediating;Methionine;methionine sulfoxide;Modeling;Morbidity - disease rate;mortality;natural hypothermia;neonatal hypoxic-ischemic brain injury;neonatal lung injury;neonatal pulmonary hypertension;neonate;Neurodevelopmental Impairment;Neurological outcome;neuron loss;Neurons;neuroprotection;Nitric Oxide;nitrosative stress;Oligodendroglia;Outcome;Oxidative Stress;Oxygen;Pharmaceutical Preparations;phosphodiesterase V;Plasma;Property;Pulmonary artery structure;pulmonary vascular disorder;Pulmonary Vascular Resistance;pulmonary vasoconstriction;pup;Rattus;Recommendation;Regimen;response;Rodent Model;Secondary to;sildenafil;standard of care;Temperature;Therapeutic;Uganda;Vasodilation;Vasodilator Agents;ventilation;Xanthines

PROJECT_TITLE: Optimal Oxygenation in Neonatal Lung Injury


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: GALVESTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Alzheimer's disease and related dementias are characterized by the intracellular aggregation of tau protein. The goals of this project are to isolate and fully characterize tau aggregates from these diseases, and to provide them along with detection agents freely to the scientific community. The availability of well-vetted resources will catalyze research into how these diseases progress, how they may be diagnosed at early stages, and how they may be efficaciously treated.

PI_NAMEs: EISENBERG, DAVID ;KAYED, RAKEZ  (contact);KEENE, CHRISTOPHER DIRK;KURET, JEFF

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Address;alpha synuclein;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid beta-Protein;animal tissue;Antibodies;Appearance;Area;Atomic Force Microscopy;Biochemical;Biological;Biological Models;biophysical analysis;brain tissue;Centrifugation;Characteristics;Chemicals;Clinical;Communities;comorbidity;corticobasal degeneration;Cryoelectron Microscopy;Detection;Diagnosis;diagnostic signature;Disease;disease diagnosis;Disease Vectors;Electrons;Filament;Fluorescence Microscopy;Genetic Polymorphism;Goals;High Prevalence;Higher Order Chromatin Structure;Human;human disease;human tissue;Immunologics;innovation;Interdisciplinary Study;Lesion;Mass Spectrum Analysis;Measurement;Methods;Mission;Molecular;Morphology;Nerve Degeneration;Neurodegenerative Disorders;novel diagnostics;novel therapeutic intervention;Pathogenesis;Pathology;Peptide Hydrolases;Pick Disease of the Brain;Polymorph;Post-Translational Protein Processing;Preparation;Progressive Supranuclear Palsy;protein aggregation;protein TDP-43;Proteins;Proteomics;Protocols documentation;Protomer;Reagent;Recombinants;Reproducibility;Research;Research Support;Resources;Role;Sampling;Severity of illness;Source;Specimen;Staging;Standardization;Structure;Surrogate Markers;synaptic function;tau aggregation;tau Proteins;Tauopathies;Tissues;tool;Toxic effect;transmission process;Validation

PROJECT_TITLE: Interdisciplinary Research Network on Biologically Active Tau Aggregate Polymorphs from Alzheimer's Disease and Related Dementias


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Emergency Care;Neurosciences;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The burden of increasing numbers of older adults in the United States continues to add to the societal burden of neurologic disease, but current treatments and prevention strategies are ineffective for many of these disorders. By supporting early translational research training and experiences for young physician-scientists, the R25 research education and research program continues to be an important mechanism for stoking the pipeline for physician-neuroscientists who will make important translational research discoveries that improve the future prevention and treatment of nervous system diseases. The translational neuroscience community at UCSF is positioned to expand the outstanding environment for the R25 program by virtue of our commitment to training physician-scientists, demonstrated track record of success, existing and anticipated future new facilities, and the research accomplishments of our faculty.

PI_NAMEs: JOSEPHSON, SCOTT ANDREW (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Adult;Brain;career;Clinical;Clinical Sciences;Collaborations;Communities;Disease;Education Projects;education research;Emergency Medicine;Ensure;Environment;experience;Faculty;Future;Goals;Home;improved;Institution;interest;Laboratories;Laboratory Research;Medical;Medical Students;Mentors;Mission;multidisciplinary;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurology;neuropathology;neurosurgery;next generation;older adult;Patients;Physicians;Positioning Attribute;Prevention;Prevention strategy;Productivity;programs;Research;research and development;Research Personnel;Research Training;Residencies;Resources;Scientist;skills;Source;success;symposium;Talents;teacher;Time;Training;translational neuroscience;Translational Research;treatment strategy;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: NINDS Research Education Programs for Residents and Fellows in Neurology, Neurosurgery, Neuropathology, Neuroradiology and Emergency Medicine (R25)


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Infectious Diseases;Prevention;Sexually Transmitted Infections

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative The proposed study will identify the strategies and underlying mechanisms by which HSV-1 circumvents eradication by the type I interferon response during primary infection, establishment of latency and latency reactivation in a mouse model of ocular infection. Recombinant viruses will be used to interrogate the mechanisms by which the latency-associated transcript (LAT) differentially subverts specific type 1 IFN responses including analysis of the roles of the newly identified small nuclear coding RNAs, which may represent actionable targets.

PI_NAMEs: GHIASI, HOMAYON  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Affect;Apoptotic;Autophagocytosis;Binding;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Code;combinatorial;Complex;cytokine;Cytokine Receptor Binding;Data;design;Development;Disease;Down-Regulation;Encephalitis;Environment;Event;Eye diseases;Eye Infections;Family;Genes;genital herpes;Herpes Labialis;Herpesvirus 1;Human;IFNAR1 gene;Immune response;In Vitro;in vivo;Individual;Induction of Apoptosis;Infection;Infection prevention;innovation;Interferon alpha;Interferon Type I;Interferons;latency associated transcript;latent persistent infection;Latent virus infection phase;Lesion;Maps;Mediating;member;Modeling;mortality;mouse model;Mus;Natural Killer Cells;neuron loss;Neurons;Nuclear;pathogenic virus;Pharyngitis;Phenotype;Play;Predisposition;Prevalence;prevent;Preventive;Primary Infection;Process;Production;promoter;protein function;Proteins;Public Health;Publishing;reactivation from latency;recombinant virus;Recurrence;Recurrent disease;recurrent infection;Regulation;response;RNA;Role;secondary infection;Signal Transduction;Simplexvirus;Site;Structure of trigeminal ganglion;System;Testing;Therapeutic;Transcript;Untranslated RNA;vaccine development;Vaccines;Virus;Virus Diseases;Virus Latency;Virus Replication;Wild Type Mouse

PROJECT_TITLE: Role of type 1 IFN in eye infection

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: TOWSON

ORG_NAME: TOWSON UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE A diverse biomedical workforce with varied lived experiences is critical for facing complex challenges in biomedicine and public health. The proposed training grant will support minoritized students as they transition from Baltimore City Community College and the Community College of Baltimore County to Towson University where they will earn their bachelor’s degree while participating in research and professional development. This program aims to increase student retention and bachelor’s degree completion while facilitating their progression to advanced STEM education and careers in the biomedical workforce.

PI_NAMEs: EHRLICH, ELANA S;GILLESPIE, KATHLEEN ;LAING, JENNIFER ;SNYDER, MICHELLE LYNN DYKSTRA (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Acute;Admission activity;Applications Grants;Bachelor's Degree;Baltimore;Biomedical Research;bridge to the baccalaureate;career;career development;Cities;college;Communities;community college;County;Creativeness;design;Development;effectiveness evaluation;empowerment;Ensure;Environment;Goals;Grant;higher education;improved;innovation;Institution;matriculation;Mentors;minority student;Program Evaluation;programs;Research Training;Science;Self Efficacy;skill acquisition;STEM field;STEM student;Students;success;tool;Training;Training Programs;transfer student;Universities

PROJECT_TITLE: Bridges to the Baccalaureate Research Training Program at Towson University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative This project is relevant to public health in so far as the major goal is to shed light on the most salient causes of the reversal of the decline in midlife mortality for U.S. white non-Hispanics with a high school education or less. The findings will contribute to evidence-based social policies and treatment interventions with the most promise for halting increased midlife mortality in an understudied sector of the population at high risk for substance abuse.

PI_NAMEs: JOHNSON, TIMOTHY PATRICK;ROSPENDA, KATHLEEN M (contact)

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: Achievement;Address;Adult;aged;aging population;Alcohol abuse;Alcohol consumption;alcohol poisoning;Alcohols;Anger;Anomie;Anxiety;Area;Baby Booms;Black Populations;Chronic;chronic liver disease;cohort;Communities;Data Analytics;Death Rate;depressive symptoms;Drug abuse;Drug usage;Economics;Education;Equation;evidence base;Female;Formulation;Gender;Generations;Goals;Growth;Health;Health Services Accessibility;Health Status;high risk;high school;Hostility;Individual;Intervention;Interview;Link;Liver Cirrhosis;Location;male;Mediating;Mediator;Medicaid;Mental Health;middle age;Modeling;mortality;Not Hispanic or Latino;Outcome;Parents;Perception;Pharmaceutical Preparations;Politics;Population;Predictive Factor;Prevalence;Psychological Factors;psychosocial;Public Health;Race;Recommendation;Religion;Research;Respondent;Rural;rural area;Sampling;service utilization;Services;social;social disparities;social engagement;Social Policies;Social status;Social support;stressor;Substance abuse problem;substance abuse treatment;suburb;Suicide;Surveys;symptomatology;Techniques;Testing;Theoretical model;theories;Time;treatment services;urban area

PROJECT_TITLE: Chronic Stressors and Alcohol and Drug Abuse in Middle-aged Adults: White/BlackDifferences

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Substance Misuse;Women's Health Research

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Alcohol use disorders have a significantly greater impact on women relative to men, which may result from sex differences in alcohol's impact on brain stress systems. This study will test for sex differences in the function and connectivity of the bed nucleus of the stria terminalis—a region critically involved in stress—in early abstinence from alcohol. Such knowledge is critical for identifying novel brain targets and guiding the development of sex-specific or personalized treatments.

PI_NAMEs: BLACKFORD, JENNIFER URBANO (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Abstinence;Acute;addiction;Address;alcohol abstinence;alcohol abuse therapy;alcohol consequences;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol seeking behavior;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;American;Animal Model;Animals;Anxiety;anxiety symptoms;Awareness;Behavior;biological adaptation to stress;Brain;Brain region;Chronic;clinically significant;Data;Dependence;depressive symptoms;Development;Diffusion Magnetic Resonance Imaging;Disabling condition;Disease;drinking;effective therapy;experience;Female;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Funding Agency;Future;Galvanic Skin Response;Health;Homeostasis;Human;Hydrocortisone;Hyperactivity;in vivo;Influentials;Intervention;Intoxication;Knowledge;Light;long term recovery;male;Measures;Mediating;men;Mental Depression;Methods;National Institute on Alcohol Abuse and Alcoholism;negative affect;Negative Reinforcements;neural network;Neurobiology;novel;Occupations;Pattern;personalized medicine;Physiology;Pilot Projects;Process;Publishing;Relapse;relapse prevention;Research;response;Rest;Role;sex;Sex Differences;sexual dimorphism;Stress;stress related disorder;Structure of terminal stria nuclei of preoptic region;Symptoms;System;Testing;theories;Translational Research;Withdrawal;Woman

PROJECT_TITLE: Sex differences in BNST networks during early abstinence in AUD

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Lung;Lung Cancer;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: CHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE. O6-Methylguanine methyltransferase (MGMT) is a DNA repair protein that converts O6-alkylguanosine residues arising from endogenous and exogenous genotoxins to guanosine. MGMT is ubiquitously expressed in healthy tissue but silenced in a broad range of cancers by promoter hypermethylation. This grant seeks to exploit MGMT silencing to develop targeted agents for the eradication of naïve and drug-resistant tumors.

PI_NAMEs: BINDRA, RANJIT ;HERZON, SETH B. (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Address;adduct;Alkylating Agents;Alkylation;Apoptosis;bench to bedside;Biological Availability;Cells;Central Nervous System Agents;Chemicals;chemotherapy;Clinic;clinically significant;Colon Carcinoma;crosslink;Cyclization;Cytosine;cytotoxicity;Data;Dealkylation;design;Development;DNA;DNA Alkylation;DNA Damage;DNA Interstrand Crosslinking;DNA Repair;DNA Repair Disorder;DNA Repair Gene;Drug resistance;efficacy evaluation;Excision;experience;functional loss;Futile Cycling;Genes;Genetic;Genome;Genomics;Glioblastoma;Glioma;Goals;Grant;Guanosine;Human;Hypermethylation;improved;in vivo;ineffective therapies;inhibitor;Ions;Kinetics;Lesion;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Methyltransferase;MGMT gene;Mismatch Repair;Modeling;Modification;mouse model;Mutagens;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;novel strategies;Oligonucleotides;Oral;Pathway interactions;Patients;Penetration;Pharmaceutical Preparations;Phenotype;Polymerase;Prodrugs;Proliferating;promoter;Radiation therapy;Reaction;repaired;Research;Resected;Resistance;response;small cell lung carcinoma;standard of care;Structure;synergism;systemic toxicity;targeted agent;temozolomide;Testing;Therapeutic;Therapeutic Index;Thymine;Time;tissue culture;Tissues;Toxic effect;Transferase;Translating;Translations;treatment strategy;trial design;tumor;tumor specificity;Work

PROJECT_TITLE: Novel therapeutics for the targeted eradication of DDR-defective tumors

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE In this competitive renewal of the UC Davis BIRCWH program (PI, Dr. Nancy Lane), we propose to build on the experience and achievements of our previous 14 years of the program to advance, promote, and achieve interdisciplinary training and mentoring of team-based science for the next generation of researchers in women’s health and sex differences. Our BIRCWH faculty, mentors, and scholars will work to improve the health of women and to improve our knowledge and understanding of the mechanisms and manifestations of sex differences in health and disease as well as of the unique afflictions women face with the ultimate goal of more effective prevention, diagnosis, and treatment.

PI_NAMEs: LANE, NANCY E (contact)

PROGRAM_OFFICER_NAME: TIGNO, XENIA

PROJECT_TERMS: Academy;Address;Aging;aging related disease;Area;Behavior;Biometry;California;career;career development;Childhood;clinical practice;Collaborations;Communication;Development;Development Plans;Disease;Environment;experience;Faculty;Female;Fostering;Foundations;Funding;Gender;gender difference;gender disparity;Grant;Health;health difference;health disparities in women;health disparity;improved;Inflammatory;innovation;interdisciplinary collaboration;Interdisciplinary Study;interest;Journals;Knowledge;life span;Malignant Neoplasms;medical schools;meetings;Mentors;Metabolic;Musculoskeletal Diseases;neurodevelopment;Neurosciences;next generation;nutrition;Opiate Addiction;Pathway interactions;programs;Research;research and development;Research Design;Research Personnel;responsible research conduct;Schools;Science;sex;Sex Differences;sex disparity;skills;symposium;Syndrome;Training;Translating;Women's Health;Writing

PROJECT_TITLE: Building Interdisciplinary Research Careers in Women's Health at UC Davis


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Rural Health;Social Determinants of Health

ORG_CITY: SPRINGFIELD

ORG_NAME: OZARK HEALTH VENTURES, LLC

ORG_STATE: MO

PHR: Narrative Cancer Research for the Ozarks, though this NCORP grant, will continue to be the primary access to NCI sponsored research for the poor, rural patients across 42 counties in its five state catchment area. This access is critical to providing these patients with cutting edge, quality cancer treatment, prevention, and care delivery research in their local communities.

PI_NAMEs: CARLSON, JAY W (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Adolescent and Young Adult;Advocate;Aftercare;American College of Radiology Imaging Network;anti-cancer research;Applications Grants;Area;base;cancer care;Cancer Center;Cancer Control;cancer health disparity;cancer prevention;cancer therapy;care delivery;Catchment Area;Caucasians;Clinical Investigator;Clinical Research;Clinical Trials;Collection;Communication;Communities;Community Clinical Oncology Program;community engagement;community partners;County;Data;Development;disparity reduction;Eastern Cooperative Oncology Group;Education;Elderly;Enrollment;Ensure;experience;Funding;Grant;Health;high standard;Image;imaging study;improved;Individual;Infrastructure;Institution;Institutional Review Boards;interest;IT collaborator;Leadership;Malignant Neoplasms;member;Minority Participation;Mission;Missouri;outreach;Ozarks;Participant;participant safety;Patient-Focused Outcomes;Patients;Pediatric Oncology Group;Population;Prevention;Process;programs;Protocols documentation;Provider;Recording of previous events;Research;Research Infrastructure;Research Personnel;research study;Research Support;Resources;Rural Community;rural patients;Rural Population;rural setting;screening;Secure;Sexual and Gender Minorities;Site;Southwest Oncology Group;Tissue Procurements;Underserved Population;United States;Woman

PROJECT_TITLE: Ozark Health Ventures LLC dba Cancer Research for the Ozarks (CRO)


NIH_SPENDING_CATS: Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE Building Interdisciplinary Careers in Women’s Health (BIRCWH) Scholars Program is developed based on the need for a science workforce with skills necessary to work in interdisciplinary teams and translate scientific discoveries into clinical practice to improve women’s health. Mayo Clinic BIRCWH program has been fulfilling this need by training Scholars who enhance the interdisciplinary research in women’s health at the Mayo Clinic and across the Nation.

PI_NAMEs: KANTARCI, KEJAL  (contact)

PROJECT_TERMS: career;career development;Center for Translational Science Activities;Centers of Research Excellence;Clinic;clinical practice;Clinical Sciences;Collaborations;collaborative environment;Communities;Education;Environment;experience;Fostering;Funding;Goals;Grant;improved;Institution;Interdisciplinary Study;Investments;Lead;Leadership;Mentors;Program Development;programs;recruit;Research;Research Personnel;Role;Science;sex as a biological variable;Sex Differences;Specialized Center;Structure;success;Training;Translating;United States National Institutes of Health;Women's Health

PROJECT_TITLE: Mayo Clinic Building Interdisciplinary Research Careers in Women’s Health


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Nutrition;Prevention;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Narrative Up to 50% of people with HIV (PWH) in the US are food insecure, yet there is limited understanding of how food insecurity (FI) affects the development of cardiometabolic disease among PWH. We propose to explore how FI contributes to the development of cardiometabolic comorbidities in PWH longitudinally and to test a novel bilingual evidence-based intervention designed to improve insulin sensitivity among PWH with prediabetes or diabetes. The intervention harnesses both peer navigation and mHealth. We will conduct this study in a predominantly rural catchment area in the US South that includes Appalachia and has high rates of both FI and HIV.

PI_NAMEs: MORSE, CARYN GEE;RHODES, SCOTT D (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: Address;Adherence;Affect;Age;Anti-Retroviral Agents;Appalachian Region;Area;bilingualism;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Caring;Catchment Area;Categories;Clinic;clinical care;clinical practice;clinical research site;Communicable Diseases;comorbidity;Data;Development;Diabetes Mellitus;ethnic diversity;Evidence based intervention;follow-up;Food;food insecurity;Funding;health care service organization;Health system;HIV;improved;Incidence;Individual;Insulin Resistance;insulin sensitivity;interest;Intervention;intervention effect;intervention participants;Interview;Longitudinal cohort;Measures;medical specialties;Methods;mHealth;Modeling;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;North Carolina;novel;Nutritional;Obesity;Participant;Patients;peer;Persons;Prediabetes syndrome;Prevalence;Provider;racial diversity;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;Risk;Rural;Rural Population;Secure;social health determinants;Structure;success;Testing;therapy design;Time;treatment as usual;trial design;Viral;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Exploring the consequences of food insecurity and harnessing the power of peer navigation and mHealth to reduce food insecurity and cardiometabolic comorbidities among persons with HIV


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Complementary and Integrative Health;Immunotherapy;Women's Health Research

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE The engineering of tumor-specific bacteria is a transformative approach to cancer therapy, since bacteria can be genetically programmed to sense and respond to environments and locally release therapeutics. This proposal seeks to engineer genetically encoded encapsulation systems to improve intravenous delivery of therapeutic bacteria for breast cancer therapy. The objective is to create probiotic strains with multiple encapsulation systems, and combine them with previous attenuations tested in clinical trials, to improve colonization efficiency and efficacy while maintaining safety.

PI_NAMEs: ARPAIA, NICHOLAS ;DANINO, TAL  (contact);LEONG, KAM W

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Adjuvant;Antibiotics;Antibody Response;Attenuated;Automobile Driving;Bacteria;Biodistribution;Biological Assay;Blood;Body Weight;bone;Bone Tissue;Brain;Breast Cancer Model;Breast Cancer Patient;Breast Cancer therapy;cancer immunotherapy;cancer therapy;capsule;Cells;Chondroitin;clinic ready;clinical candidate;Clinical Trials;clinically relevant;Colorectal Cancer;Combined Modality Therapy;cytokine;Cytolysis;Data;Disease;Dose;Drops;Encapsulated;Engineered Probiotics;Engineering;Environment;Escherichia coli;Face;Flagella;Frequencies;Future;Genes;Genetic;Genetic Engineering;Genomics;Goals;Human;Immune Evasion;immune-related adverse events;immunogenicity;Immunologic Surveillance;Immunotherapeutic agent;Immunotherapy;improved;In complete remission;In Vitro;in vitro Assay;in vivo;Individual;Injections;Intravenous;intravenous administration;intravenous injection;Knock-out;Lipid A;Lipopolysaccharides;Liver;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Maximum Tolerated Dose;Measures;Medicine;Methods;microbial;Modification;mouse model;Mus;Mutation;Neoplasm Metastasis;novel;novel therapeutics;Oral;Organ;patient safety;Patients;Polysaccharides;Polysialic Acid;preclinical trial;prevent;Primary Neoplasm;Probiotics;Production;Reporter;Reporting;research clinical testing;response;Safety;safety assessment;safety engineering;safety testing;Serratia;side effect;Soft tissue sarcoma;Specificity;Streptococcus;success;Surface;synthetic biology;System;systemic toxicity;Testing;Therapeutic;Toxic effect;Toxin;Translations;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;Tumor Burden;tumor hypoxia;Tumor Immunity;Tumor Promotion;Work

PROJECT_TITLE: Programmable encapsulation systems to improve delivery of therapeutic bacteria

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Over the past decade, it has become increasingly clear that the processing, turnover, and generation of lipids in the brain is altered in many aspects of brain disease. However, there is currently no brain-wide atlas of regional lipid distribution and lipidomics in the brain, which is relevant for the functional consequences of lipid metabolism and in the context of disease. Here, we propose to address this major gap by generating a mouse lipidomics reference atlas of the brain, and integrating it with the Allen Brain structural connectivity and gene expression atlases in mouse models of Alzheimer's disease and human brain.

PI_NAMEs: MCINTIRE, LAURA BETH JOHNSON (contact);MENON, VILAS ;NURIEL, TAL

PROJECT_TERMS: abeta accumulation;Address;Age;age related;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;amphiphysin;Animal Model;Animals;Apolipoprotein E;apolipoprotein E-4;Atlases;Autopsy;Behavioral;Binding Proteins;Biochemical;Biological;Biological Assay;Biological Markers;biomarker development;biomarker identification;Brain;Brain Diseases;Brain region;brain tissue;cell type;Cells;Cerebrospinal Fluid;Characteristics;cholesterol transporters;Clinic;Cognitive deficits;comparison control;Data;Disease;Disease Progression;Docosahexaenoic Acids;entorhinal cortex;Enzymes;exhaustion;familial Alzheimer disease;fatty acid metabolism;Freezing;frontal lobe;Future;Gene Expression;Gene Expression Profile;gene network;Generations;Genes;Genetic;Genetic Risk;genetic risk factor;Genetic study;genetic variant;genome wide association study;Head;Hippocampus;Homeostasis;Human;human disease;Human Genetics;Image;immunocytochemistry;In Situ;innovation;Inositol;insight;Late Onset Alzheimer Disease;Lecithin;lipid metabolism;lipidome;lipidomics;Lipids;Lysophosphatidylcholines;lysophosphatidylinositol;Manuscripts;Maps;mass spectrometric imaging;Mediating;Memory;Metabolic;Metabolic Pathway;metabolic profile;Metabolism;Methods;Microglia;mild cognitive impairment;mouse model;multidimensional data;Mus;Neurodegenerative Disorders;Nonesterified Fatty Acids;novel;participant enrollment;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pattern;peripheral blood;Phase;Phenocopy;Phosphatidylethanolamine;Phosphatidylinositols;Phospholipase A2;phospholipase D2;Phospholipid Metabolism;Phospholipids;Phosphoric Monoester Hydrolases;Plasma;PLCgamma2;Polyphosphates;Polyunsaturated Fatty Acids;Prefrontal Cortex;Preparation;public database;Radiolabeled;religious order study;Reporting;Research Personnel;Resolution;Role;Signal Transduction;Specificity;Stereotyping;SYNJ1 gene;System;tau Proteins;Testing;therapeutic target;tissue processing;Tissues;transcriptomics;Validation;Variant;Work

PROJECT_TITLE: Spatial dysregulation of the lipidome in Alzheimers disease human and mouse brain


PHR: PROJECT NARRATIVE The UCSF-KPNC Building Interdisciplinary Research Careers in Women's Health (BIRCWH) Program offers mentored training to scholars to advance women's health in the U.S. through the study of sex and gender influences in health and disease. The program strengthens interdisciplinary research skills and trains researchers in women's health for successful careers in team science focused on topics of public health importance, ultimately improving the health of US women.

PI_NAMEs: BRINDIS, CLAIRE D.;HARPER, CYNTHIA C (contact)

PROJECT_TERMS: addiction;Advisory Committees;Area;Biomedical Research;bone health;California;career;career development;Clinical Research;Clinical Sciences;Cognition;Communicable Diseases;design;Discipline;Disease;Environmental Health;Ethnic Origin;experience;Faculty;Fostering;Gender;Health;Health Sciences;Institution;interdisciplinary approach;Interdisciplinary Study;interest;Leadership;leadership development;life span;Malignant Neoplasms;Measures;Mental Health;Mentors;Metabolism;Modeling;multidisciplinary;Outcome;Productivity;professor;Program Effectiveness;Program Evaluation;programs;Public Health;Race;recruit;Reproductive Health;Research;Research Methodology;Research Personnel;Resources;San Francisco;Science;sex;Surveys;Training;training opportunity;Translational Research;Universities;Woman;Women's Health

PROJECT_TITLE: UCSF-Kaiser Department of Research Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) Program


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Lung;Lung Cancer;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

PHR: NARRATIVE Many people living with HIV (PLWH) smoke. Smoking in these individuals is often undertreated. We plan to study the ability of various clinical pathways involving tobacco treatment medications and contingency management (paying smokers for not smoking) to improve smoking cessation in a group of PLWH.

PI_NAMEs: BERNSTEIN, STEVEN L;EDELMAN, E. JENNIFER (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, ANNETTE R

PROJECT_TERMS: Abstinence;Acquired Immunodeficiency Syndrome;addiction;Address;Adult;Agonist;Algorithms;antiretroviral therapy;arm;behavior change;Behavior Therapy;Behavioral;Biological Markers;Carbon Monoxide;Cardiovascular Diseases;Caring;Cause of Death;CD4 Lymphocyte Count;Chronic;cigarette smoke;cigarette smoking;Clinic;Clinical Pathways;Clinical Pharmacists;Clinical Trials;Clinical Trials Design;clinically relevant;cohort;comparative effectiveness;Conduct Clinical Trials;contingency management;Data;Data Analyses;design;effectiveness study;effectiveness/implementation hybrid;Enrollment;Evaluation;evidence base;Exhalation;future implementation;General Population;Goals;Health;Health system;Healthcare Systems;HIV;implementation science;improved;Incentives;indexing;Individual;information gathering;innovation;Intervention;Leadership;Life Expectancy;Lung Diseases;Malignant Neoplasms;Measures;Medical;Medication Management;Mental Depression;Meta-Analysis;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;neglect;New York;nicotine replacement;Nicotinic Receptors;non-smoking;novel;optimal treatments;Outcome;Pain;Participant;Patient Care;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Pharmacists;pharmacologic;primary outcome;Prize;process evaluation;Promoting Action on Research Implementation in Health Services framework;Publishing;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Regimen;Relapse;Reproducibility;Research;Research Design;responders and non-responders;response;Rewards;Role;Sample Size;Sampling;Sequential Multiple Assignment Randomized Trial;Site;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;smoking intervention;smoking prevalence;Smoking treatment;Specific qualifier value;Testing;Time;Tobacco;tobacco cessation intervention;Tobacco use;Tobacco Use Disorder;Training;Treatment Protocols;treatment response;treatment strategy;trial design;United States Health Resources and Services Administration;United States National Institutes of Health;varenicline;Viral;Viral Load result;years of life lost

PROJECT_TITLE: A SMART Approach to Treating Tobacco Use Disorder in Persons Living with HIV


NIH_SPENDING_CATS: Infant Mortality;Lung;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Sleep Research;Sudden Infant Death Syndrome

ORG_CITY: BOSTON

ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Narrative Neonates and infants frequently experience breathing interruptions, called apneas, and an impaired response to these apneas may begin a process that tragically ends in Sudden Infant Death Syndrome (SIDS). Autoresuscitation is the reflex process that allows babies to recover successfully from apneas, and serotonin, a neurotransmitter in the brain, plays an essential role organizing and driving this reflex, yet it seems likely that many babies who died of SIDS lacked sufficient serotonergic neuron function in the brainstem, which may be the reason that autoresuscitation fails in these babies. We have discovered a set of neurons, we call `para- serotonergic neurons,' that may transform into serotonin-producing cells as part of a compensatory neural adaptation to stress that promotes a normal autoresuscitation response and reduces the chance of SIDS, and we propose deep functional and molecular characterization of these cells, motivated by their potential as a therapeutic target for pediatric disorders involving cardiorespiratory dysfunction.

PI_NAMEs: DYMECKI, SUSAN M. (contact);HAYNES, ROBIN LYNN;LEITER, JAMES C.

PROJECT_TERMS: Acute;Adult;Affect;Apnea;Area;Arousal;Automobile Driving;Autoreceptors;Binding;Birth;Brain;brain control;Brain Stem;brain tissue;Breathing;Buffers;Cell Count;Cell Size;cell type;Cells;Characteristics;Childhood;Chronic;cohort;comparative;comparison control;Data;Date of birth;designer receptors exclusively activated by designer drugs;Development;Disease;Dorsal;Engineering;Enzymes;Epidemiology;Exhibits;experience;Exposure to;Failure;Functional disorder;functional plasticity;GATA3 gene;Genes;gestational hypoxia;Harvest;Heterogeneity;hindbrain;Human;hypoglossal nucleus;Hypoxia;immunocytochemistry;Impairment;In Situ;In Situ Hybridization;Infant;Infant Mortality;insight;Interruption;Investigation;Label;Life;Link;Location;Methods;Molecular;molecular phenotype;molecular subtypes;Morphology;Mus;Neonatal;neonate;nerve supply;neuroadaptation;Neuronal Plasticity;Neurons;Neurotransmitters;Newborn Animals;Newborn Infant;normoxia;novel;Perinatal;Phenotype;phenotypic biomarker;Play;Population;postnatal;postneonatal mortality;Pregnancy;prenatal;prenatal exposure;prenatal risk factor;preventive intervention;Process;Prospective Studies;pup;raphe nuclei;Rattus;Recovery;Reflex action;Resolution;respiratory;Respiratory Center;response;reuptake;Risk;Risk Factors;Rodent Model;Role;Serotonergic System;Serotonin;Shapes;Signal Transduction;single-cell RNA sequencing;social defeat;Stress;stressor;Structure;Sudden infant death syndrome;System;Testing;therapeutic target;Tissues;TPH2;Transcript;transcription factor;transcriptomics

PROJECT_TITLE: Does neurotransmitter plasticity of para-serotonergic neurons augment autoresuscitation following perinatal stress and buffer SIDS risk?

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Aging;Clinical Research;Women's Health Research

ORG_CITY: PORTLAND

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project Narrative The diverse across overarching goa l of this training program is to foster the development of early-stage research faculty from backgrounds and disciplines to develop leaders in women's health and sex/gender-based research the lifespan. We apply the lifespan approach to faculty career development and science preparing BIRCWH Scholars to lead new initiatives advancing NIH ORWH research priorities.

PI_NAMEs: MYATT, LESLIE  (contact)

PROJECT_TERMS: Adult;Age;career development;Childhood;Collaborations;collaborative environment;Communities;Country;Dedications;Development;Discipline;diversity and equity;Educational Curriculum;Endowment;equity, diversity, and inclusion;Ethnic Origin;Event;Faculty;Funding;Future;Gender;gender difference;Goals;in utero;Industry;Infrastructure;innovation;Institution;inter-institutional;Interdisciplinary Study;Lead;Leadership;life span;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Oregon;Paper;Peer Review;Positioning Attribute;Process;Program Development;programs;Publishing;Race;recruit;reproductive;Research;research faculty;Research Infrastructure;Role;Science;sex;Sex Orientation;social media;Strategic Planning;success;symposium;Thinking;Training;Training and Infrastructure;United States National Institutes of Health;Women's Health

PROJECT_TITLE: Oregon BIRCWH: Scholars in Women's Health Research Across the Lifespan

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-W(50)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Kidney Disease;Patient Safety;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative  Patients with chronic kidney disease have a higher risk for early death and kidney failure. In this study we will collect medical and socioeconomic information from patients, blood and urine samples and do a kidney biopsy to obtain samples of kidney tissue. The information will be used to understand what leads to the progression of kidney disease and to develop new treatments to avoid future complications in patients.

PI_NAMEs: TOTO, ROBERT DANIEL;VAZQUEZ, MIGUEL A (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: Address;adjudication;Adverse event;Advocate;Affect;African American;American;Biological;Biopsy;Blood;Caring;Case Study;Cessation of life;Chronic Kidney Failure;Clinical;Clinical and Translational Science Awards;Clinical Data;clinical diagnosis;clinical phenotype;Clinical Research;cohort;Collaborations;Collection;Communities;community advisory board;community engagement;Consent;Coupled;COVID-19 pandemic;Data;design;Diabetes Mellitus;diabetic;Diagnosis;Doctor of Philosophy;Electronic Health Record;electronic health record system;End stage renal failure;Enrollment;Ensure;Ethics;Evaluation;Faculty;Feces;Feedback;Focus Groups;follow-up;Fostering;Future;Goals;Health system;Healthcare Systems;high risk;Hispanic;Hypertension;hypertensive;improved;Individual;informatics tool;Information Technology;innovation;Intervention;Interview;Kidney;kidney biopsy;Kidney Diseases;Kidney Failure;Knowledge;Latinx population;Leadership;Link;Longitudinal cohort study;Medical Economics;member;Metadata;Methodology;Methods;Modeling;Molecular;novel;novel strategies;Nurses;Nursing Research;operation;Outcome;Participant;participant enrollment;Pathologic;patient engagement;patient oriented;patient population;Patient Recruitments;Patient-Focused Outcomes;Patients;personalized care;Phenotype;phenotypic data;Physicians;Policies;Population;Positioning Attribute;precision medicine;Precision Medicine Initiative;primary outcome;Privatization;Procedures;Process;Prospective Studies;Protocols documentation;Public Health;Publications;Questionnaires;radiologist;recruit;Reporting;Research;Research Personnel;Safety;safety net;Sampling;Scientist;Shipping;Site;skills;Socioeconomic Factors;socioeconomics;sound;Structure;success;Time;Tissue Banks;Tissues;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Update;Urine;Vulnerable Populations;Work

PROJECT_TITLE: Kidney Precision Medicine Project - Patient Engagement


ORG_CITY: ATLANTA

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative A practical automated system for complex carbohydrate synthesis is currently unavailable. Iterative enzymatic assembly of carbohydrates is attractive for automation, the final roadblock is the lack of simple and efficient methods for rapid intermediate and product separation. Here we propose a DNA hybridization/dehybridization- based catch-and-release method to tackle the remaining challenge toward the automatic enzymatic synthesis of complex carbohydrates.

PI_NAMEs: LI, LEI  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Affinity;Alkynes;Automation;Azides;base;Biological;Buffers;Carbohydrates;Cells;chemical synthesis;Chemicals;Chemistry;cold temperature;Complement;Complementary DNA;Complex;Consumption;Derivation procedure;Disease;DNA;Electrostatics;Ensure;Evaluation;functional group;Future;Glycoconjugates;glycosyltransferase;High temperature of physical object;human milk oligosaccharides;Immobilization;Length;Liquid substance;Medical;medical specialties;melting;Methods;Monosaccharides;Nucleic Acids;oligo (dT);Oligonucleotides;Organic solvent product;Peptides;Phase;Planets;Plant Resins;Play;Polysaccharides;Procedures;Process;rapid technique;Reaction;reaction rate;Role;Route;Salts;Sepharose;Single-Stranded DNA;Sodium Chloride;Solid;Solvents;Structure;success;System;Technology;Thigh structure;Time;Vertebral column;Water;Work

PROJECT_TITLE: Expedite Enzymatic Assembly of Glycans via DNA (de)Hybridization-Enabled Catch-and-Release

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Diabetes;Emerging Infectious Diseases;Infectious Diseases;Lung;Microbiome;Nutrition;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: PROJECT NARRATIVE Our understanding of why patients with tuberculosis and type 2 diabetes mellitus have suboptimal systemic drug concentrations and poor clinical outcomes is limited. This project will examine the complex relationship between diabetes, drug pharmacokinetics, and the microbiome in relation to the treatment of patients with active tuberculosis. New insights into the mechanisms underlying low drug exposures in patients with tuberculosis and diabetes may ultimately lead to novel strategies targeting the gut microbiome, aimed at optimizing the clinical care of this devastating infectious disease throughout the world.

PI_NAMEs: NARAYANAN, NAVANEETH  (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: absorption;Active Learning;Address;antimicrobial;Antitubercular Agents;Bacteria;Bioinformatics;Biological;Biological Availability;biomarker identification;Butyrates;career;career development;Cause of Death;Cessation of life;Clinical;clinical care;Clinical Investigator;Clinical Pharmacology;Clinical Research;Communicable Diseases;comorbidity;Complex;Data;Development Plans;Diabetes Mellitus;Doctor of Pharmacy;drug disposition;drug efficacy;Drug Exposure;Drug Kinetics;drug metabolism;dysbiosis;Future;Goals;Grant;gut bacteria;gut dysbiosis;gut microbiome;gut microbiota;Heterogeneity;Human;Human Microbiome;improved;Infrastructure;innovation;insight;interest;International;isoniazid;Knowledge;Link;mathematical model;Measures;Mediating;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Metabolic Diseases;Metabolism;Methodology;microbial;microbial community;microbiome;microbiome research;microbiome signature;Modeling;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Oral;Outcome;patient oriented research;Patients;Pharmaceutical Preparations;pharmacokinetic model;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;pharmacometrics;Pharmacotherapy;Phenotype;Population;prevent;programs;prospective;Pyrazinamide;Regimen;Relapse;Research;Research Activity;research and development;Research Design;Research Personnel;Rifampin;Sampling;Science;Secure;skills;Sputum;Statistical Data Interpretation;stool sample;Systems Biology;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapy design;therapy resistant;Time;Training;Training Activity;translational scientist;treatment and outcome;Treatment Failure;Treatment outcome;treatment response;treatment risk;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Variant

PROJECT_TITLE: Gut Microbiome and Pharmacokinetic Variability in Tuberculosis and Diabetes

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Precision Medicine;Social Determinants of Health

PHR: Even though chronic kidney disease (CKD) affects nearly 40 million Americans, advances in the treatment of CKD lag behind advances in the treatment of other diseases. The Kidney Precision Medicine Project (KPMP) aims to reduce the burden of CKD by facilitating the development of precision medicine approaches for the treatment and prevention of CKD. The University of Illinois at Chicago KPMP CKD Recruitment Site research team will make significant contributions to the operational and scientific missions of KPMP by accomplishing the following goals: 1) enroll a diverse cohort of 150 adults with CKD to undergo a research kidney biopsy and longitudinal follow-up and 2) implement a systematic evaluation of neighborhood-level measures of social determinants of health which will advance the long-term mission of KPMP to deeply characterize disease subgroups.

PI_NAMEs: LASH, JAMES P. (contact);RICARDO, ANA CATHERINE

PROJECT_TERMS: Address;Adopted;Adult;Affect;Algorithms;American;Atlases;Benefits and Risks;Bioethics;Bioethics Consultants;Biometry;Black race;built environment;career;Characteristics;Chicago;Chronic Kidney Failure;Chronic Kidney Insufficiency;Classification;Clinic Visits;Clinical;clinical center;clinical phenotype;cohort;Cohort Studies;Collaborations;Communities;community advisory board;Coupling;Data;Data Collection;Development;Diabetic Nephropathy;Diagnosis;Disease;disease heterogeneity;Disease Progression;disorder subtype;Economics;Electronic Health Record;Eligibility Determination;Enrollment;Ensure;Ethics;ethnic minority population;Evaluation;experience;Federally Qualified Health Center;follow-up;Glomerular Filtration Rate;Goals;Health;Health Sciences;Healthcare Systems;Heterogeneity;Hispanic;Illinois;improved;inclusion criteria;Individual;Infrastructure;insight;interest;Interventional radiology;Interview;Kidney;kidney biopsy;Kidney Diseases;Letters;Link;Longitudinal Studies;Malignant Neoplasms;Measures;meetings;Methods;Mission;molecular phenotype;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Neighborhoods;Nephrology;Not Hispanic or Latino;Ontology;Outcome;Participant;Pathology;patient engagement;patient oriented;patient population;patient portal;Patients;personalized medicine;Persons;Phenotype;phenotypic data;Play;Population Heterogeneity;precision medicine;Prevention;primary care provider;Proteinuria;Protocols documentation;Public Health;racial minority population;recruit;Reporting;Research;Research Personnel;retention rate;Rheumatism;Role;Site;social;social health determinants;Structure;System;Telephone;Time;Underrepresented Minority;United States;Universities;Visit;Work;working group


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Relevance to Public Health The proposed research approach will provide mechanistic insights into the evolutionary dynamics arising from the combination treatment of resistant bacteria. These insights will guide the design of effective treatment strategies that can extend the shelf-life of existing antibiotics.

PI_NAMEs: YOU, LINGCHONG  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Active Sites;Adjuvant;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteria;Bacterial Antibiotic Resistance;bacterial resistance;beta-Lactam Resistance;beta-Lactamase;beta-Lactams;Binding;Biological Assay;Biological Models;Cells;Cessation of life;Clinical;Clinical Treatment;Combined Modality Therapy;Computer Models;design;Economics;effective therapy;efficacy testing;Engineering;Enterobacteriaceae;Enzymes;experimental study;Extended-spectrum β-lactamase;Formulation;Gram-Negative Bacteria;Growth;Health Care Costs;Hydrolysis;Incidence;Individual;Infection;inhibitor;Inpatients;insight;Investments;Learning;Life;mathematical model;Measures;Mediating;Metabolic;microbial community;Modeling;mortality;novel;Outcome;Outpatients;pathogen;pathogenic bacteria;Penetration;Penicillins;periplasm;Physiological;Population;Population Heterogeneity;predictive modeling;preservation;prevent;Privatization;Production;Public Health;Regimen;Research;Resistance;Resistance development;resistance mechanism;response;System;Testing;Thinness;Treatment Efficacy;treatment strategy;United States;Variant;Work

PROJECT_TITLE: Evolutionary dynamics of combinational antimicrobial treatments

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Hematology;Inflammatory Bowel Disease;Machine Learning and Artificial Intelligence;Patient Safety;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Randomized clinical trials of anticoagulants vastly under-represented patients with inflammatory bowel disease [IBD] despite their increased risk of venous thromboembolism [VTE]. Using inpatient data, outpatient data, machine learning algorithms, and data linkage, the applicant will evaluate the risks and benefits of anticoagulants in IBD patients.

PI_NAMEs: DAWWAS, GHADEER K. (contact)

PROGRAM_OFFICER_NAME: NEIDERT, LESLIE EAVES

PROJECT_TERMS: Acute;Adherence;Affect;alternative treatment;American;American Heart Association;Anticoagulants;appropriate dose;Attention;Award;Benefits and Risks;Biometry;career development;Characteristics;comparative effectiveness;comparative safety;Crohn's disease;Data;Data Linkages;Databases;design;Diagnosis;Discipline;Disease;disorder subtype;Effectiveness;effectiveness evaluation;Electronic Health Record;Epidemiology;Event;Exclusion;experience;Flare;Fright;Future;Gastroenterology;Goals;Hematology;Hemorrhage;Hemostatic function;Heparin;high risk;high risk population;hospital readmission;Hospitalization;Hospitals;improved;Inflammatory Bowel Diseases;Infrastructure;Inpatients;Institution;International;Knowledge;Learning Skill;Link;Low-Molecular-Weight Heparin;Machine Learning;machine learning algorithm;Methodology;Mission;Modeling;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Oral;Outpatients;Pathway interactions;Patients;Pennsylvania;Phase;Population;Postpartum Period;predictive modeling;prevent;Prevention;Primary Prevention;prophylactic;Prophylactic treatment;randomized, clinical trials;Recommendation;Recurrence;recurrence prevention;Research;Research Personnel;Research Priority;Risk;Risk Factors;Role;Safety;Secondary Prevention;Societies;Source;subcutaneous;Subgroup;success;Techniques;Thrombosis;thrombotic;Time;Training;Ulcerative Colitis;Universities;venous thromboembolism;Warfarin

PROJECT_TITLE: Anticoagulant use, safety, and effectiveness for venous thromboembolism prevention in inflammatory bowel disease patients

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Primary Health Care;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative Preterm births are common and costly, and medical and public health experts recommend preventive health care as one strategy to reduce preterm birth rates. Considering that many interconception women with a history of preterm birth do not receive preventive health care but have frequent contact with pediatric health systems in their roles as mothers, we propose a pediatric-based nurse intervention as a novel strategy to reduce preterm births. We hypothesize that care coordination activities will increase receipt of recommended preventive care and that motivational interviewing will support positive behavior change, leading to improvements in subsequent birth outcomes including decreased repeat preterm births.

PI_NAMEs: GREGORY, EMILY F (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Academy;Address;Adult;adverse birth outcomes;Articulation;barrier to care;behavior change;Behavioral;behavioral health;Birth;Birth Intervals;Birth Rate;care coordination;Care given by nurses;career;Caring;Child health care;Childhood;Clinical;cost;Data;disparity reduction;Enrollment;Ensure;evidence base;experience;feasibility testing;Goals;Guidelines;Health;health care delivery;health care service;health care service utilization;health care settings;health disparities in women;Health education;Health system;Healthcare;Healthcare Systems;high risk;High Risk Woman;implementation science;improved;improved outcome;Infant;Infant Mortality;innovation;insight;Intervention;Interview;Maternal and Child Health;maternal risk;Medicaid;Medical;Medicine;Mental Health;Mentors;Methods;Modeling;modifiable behavior;modifiable risk;Modification;Mothers;Motivation;motivational enhancement therapy;National Institute of Child Health and Human Development;novel strategies;nursing intervention;Obesity;Outcome;patient oriented;pediatrician;Pediatrics;Population;post pregnancy;Postpartum Depression;Postpartum Women;Pragmatic clinical trial;pragmatic randomized trial;Pregnancy;Pregnancy Outcome;premature;Premature Birth;prevent;Preventive care;Preventive healthcare;primary outcome;programs;Public Health;Qualitative Methods;randomized trial;Recommendation;Recording of previous events;Recurrence;Research;Research Personnel;Research Priority;Research Proposals;Risk;Risk Factors;Role;screening;secondary outcome;Services;skills;Techniques;Testing;Tobacco use;Training;training opportunity;treatment as usual;United States;Weight;Woman;Women's Health;Work

PROJECT_TITLE: The role of pediatric interconception care in preventing adverse birth outcomes

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Lymphatic Research;Lymphoma;Pediatric;Pediatric Cancer;Rare Diseases

PHR: NARRATIVE During the previous funding period of this R01, we discovered that -contrary to established dogma- central tolerance mechanisms are not only efficient at removing newly formed autoreactive B-cells but also eliminate B- cell tumors that originate from early stages of B-cell development, including B-cell acute lymphoblastic leukemia (ALL), mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL). Here we test the overarching hypothesis that central tolerance mechanisms represent a novel class of therapeutic targets in B-cell tumors that arise from early B-cell development (B-ALL, CLL and MCL).

PI_NAMEs: MÜSCHEN, MARKUS  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acute Lymphocytic Leukemia;Adult;Agonist;anergy;Antigens;Autoantibodies;Autoimmune Diseases;autoreactive B cell;B lymphoid malignancy;B-Cell Acute Lymphoblastic Leukemia;B-Cell Antigen Receptor;B-Cell Development;B-Cell Neoplasm;B-Lymphocytes;Biogenesis;Biological Markers;cancer type;Cell Death;Cell Size;cell type;Cells;central tolerance;Chronic Lymphocytic Leukemia;chronic lymphocytic leukemia cell;Cytoplasm;Disease;disease model;Drug resistance;Engineering;experimental study;Frequencies;Funding;Genetic Diseases;Hour;Human;kinase inhibitor;Knock-in Mouse;Late Effects;Light;Malignant Childhood Neoplasm;Malignant Neoplasms;Mantle Cell Lymphoma;Mediating;Mitochondria;Modeling;mouse model;novel;novel therapeutic intervention;nuclear factors of activated T-cells;optogenetics;Pathologic;patient derived xenograft model;Patients;Persons;pharmacologic;Pharmacotherapy;Phosphorylation;Physiologic pulse;PIK3CG gene;Play;pre-clinical;Predisposition;prevent;promoter;Protein Phosphatase 2A Regulatory Subunit PR53;Protein Tyrosine Kinase;PTEN gene;purge;Refractory;Relapse;Resistance development;Role;side effect;Signal Transduction;small molecule inhibitor;SYK gene;T-Lymphocyte;Testing;therapeutic target;Toxic effect;tumor;Validation;ZAP-70 Gene

PROJECT_TITLE: Central tolerance mechanisms in B-cell malignancies

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Hearing Loss;Neurosciences;Pediatric;Rehabilitation

PHR: Project Narrative (Public Health Relevance) During face-to-face communication, speech is audiovisual: access to visual cues (i.e., lipreading) is particularly helpful in preserving speech recognition when the auditory components of speech are degraded by hearing loss, background noise, or distortion. The present study examines the extent to which visual speech cues facilitate real-time spoken language processing and downstream language comprehension in children with permanent sensorineural hearing loss who use cochlear implants, a population that is at risk for speech and language delay due to their altered experience with sound. The results of the study will provide a comprehensive model of real-time speech recognition, with and without visual speech cues, in school-age children with cochlear implants or with normal hearing as well as inform future studies spoken language interventions for children with hearing loss that vary in their inclusion of visual speech cues.

PI_NAMEs: GRIECO-CALUB, TINA M (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Address;Adult;Age;audiovisual speech;Auditory;auditory processing;Behavior;Bilateral;Child;Childhood;Cochlear Implants;Cognitive;Communication;Compensation;comprehension skill;Cueing for speech;Cues;Data;Development;experience;experimental study;Exposure to;Face;Future;Goals;Growth;Hearing;hearing impairment;holistic approach;improved;Intervention;Knowledge;Language;language comprehension;Language Delays;Language Development;language outcome;language processing;Learning;lexical;lexical processing;Life;Lipreading;Measures;Modeling;multimodality;Nature;Noise;normal hearing;Nursery Schools;Outcome;Partner Communications;peer;Performance;Population;preservation;Process;public health relevance;real time model;recruit;Research;response;Risk;School-Age Population;Sensorineural Hearing Loss;skills;sound;Speech;speech accuracy;Speech Delay;Speech Perception;speech recognition;Speed;Testing;Time;Training;Visual;visual speech;Vocabulary;Work

PROJECT_TITLE: The influence of visual speech on lexical access in children

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Neuroblastoma;Neurosciences;Rare Diseases

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Project Narrative The studies proposed in this application seek to elucidate at the molecular level how the reversible attachment of phosphate to the amino acid histidine in proteins regulates their activity. By analogy with addition of phosphate to serine, threonine and tyrosine, the phosphorylation of histidine is likely to play an important role in normal cell function and in human disease, and in particular cancer, and could serve as a new cancer therapeutic target.

PI_NAMEs: HUNTER, TONY R. (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Acids;Affinity;Amino Acids;Antibodies;Bacteria;Binding;Cell Line;Cell Physiology;Cells;Childhood;Comparative Study;detection of nutrient;Enzymes;experimental study;Fab Immunoglobulins;Histidine;Histone H4;Human;human disease;Immunofluorescence Immunologic;improved;Individual;inorganic phosphate;Malignant neoplasm of pancreas;Malignant Neoplasms;Mammals;Methods;Molecular;Monoclonal Antibodies;Mus;Neuroblastoma;NME1 gene;Normal Cell;novel therapeutic intervention;Peptides;phosphohistidine;Phosphoric Monoester Hydrolases;Phosphorylation;Play;Post-Translational Protein Processing;Potassium Channel;Primary carcinoma of the liver cells;Protein Isoforms;Proteins;Protocols documentation;Reagent;receptor;Recording of previous events;Role;Series;Serine;Signal Transduction;Site;Site-Directed Mutagenesis;Stains;Structure;Surface;System;targeted cancer therapy;therapeutic target;Threonine;tool;tumor;Tumor Cell Line;Tumor Suppressor Proteins;Tumor Tissue;Tyrosine;Western Blotting

PROJECT_TITLE: Histidine phosphorylation as a new target for cancer therapy


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Prevention;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Anterior uveitis is the most common form of intraocular inflammation in children and can lead to permanent vision loss and disability if not adequately detected and treated. Current clinical evaluation of intraocular inflammation using slit lamp biomicroscopy is operator-dependent and semi-quantitative. We will evaluate the use of multiple instrument-based objective measures of intraocular inflammation in children, which can potentially enable better detection and monitoring of uveitis so that prompt treatment can be implemented to prevent blindness and disability.

PI_NAMEs: TSUI, EDMUND  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adult;Algorithms;Anterior;anterior chamber;Anterior uveitis;Arthritis;Award;Biometry;Blindness;California;Cells;Child;Childhood;Chronic;Clinical;clinical practice;Clinical Research;clinical trial implementation;Clinical Trials;Control Groups;Cross-Sectional Studies;design;Detection;Development;Diagnosis;disability;Disease;Early Diagnosis;Epidemiology;Evaluation;Eye;Eye Development;Flare;Goals;Grant;high risk;Image;Image Analysis;image processing;Immunosuppressive Agents;improved;Inflammation;instrument;K-Series Research Career Programs;Lasers;Learning;Longitudinal Studies;longitudinal, prospective study;Los Angeles;Master of Science;Measurement;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Modeling;Monitor;multidisciplinary;Nomenclature;Onset of illness;Ophthalmology;Optical Coherence Tomography;Outcome;patient oriented;patient oriented research;Patient Recruitments;Patients;Pediatrics;Periodicals;Photometry;Play;preservation;prevent;professor;Proteins;Reproducibility;Research;research clinical testing;Research Personnel;Rheumatology;Risk;risk prediction;risk stratification;Role;routine screening;Scanning;Scientist;screening;skills;slit lamp imaging;Specialist;Standardization;Symptoms;System;Techniques;Time;Toxic effect;Training;treatment response;Universities;Uveitis;Vision;vision development;Visual;Visual disability;working group

PROJECT_TITLE: Objective Measures of Intraocular Inflammation in Pediatric Anterior Uveitis


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: SAN MARCOS

ORG_NAME: TEXAS STATE UNIVERSITY

PHR: Project Narrative Our health depends greatly on a balanced gut microbiota, in which methanogenic archaea are sufficiently numerous to regulate hydrogen but not dominant to the point of causing gastrointestinal and metabolic diseases. Central to these archaeal energy metabolisms is methyl-coenzyme M reductase, a nickel enzyme that reversibly generates methane but does so through several intermediates with unknown active-site structures. Studying synthetic nickel complexes with high fidelity to the methyl-coenzyme M reductase active site will help us understand how methane is processed, and will teach us how to efficiently mediate C–H activation, a reaction that can expedite the syntheses of complex pharmaceuticals important to human medicine.

PI_NAMEs: SCHILTER, DAVID  (contact)

PROGRAM_OFFICER_NAME: NANDA, JAGPREET SINGH

PROJECT_TITLE: Active-site models unravel mechanism of enzymatic alkane activation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE We propose to conduct the first multi-site clinical therapeutic trial in semantic variant primary progressive aphasia (svPPA), and thereby establish the methodology and infrastructure to support many future multi-site therapeutic trials targeting frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP). Our investigation of the safety, tolerability, pharmacokinetics, and preliminary pharmacodynamic signature of Verdiperstat (BHV-3241), a novel myeloperoxidase inhibitor, will be an important first step in clinical research elucidating the potential pathogenic role of microglial oxidative species in FTLD-TDP. Additionally, our exploration of BHV-3241's effects on candidate fluid biomarkers of neurodegeneration, glial activation markers, and unbiased CSF proteomics, will potentially fill an unmet need for valid pharmacodynamic biomarkers of drug target engagement in FTLD-TDP trials investigating BHV-3241 and other therapeutic candidates.

PI_NAMEs: BOXER, ADAM L.;LJUBENKOV, PETER ALEXANDER (contact)

PROGRAM_OFFICER_NAME: CLARKE, AKANNI YAO

PROJECT_TERMS: Address;Adverse event;Alzheimer's Disease;Alzheimer's disease diagnosis;American;Area;Attenuated;Autopsy;Binding Proteins;Biological;Biological Assay;Biological Availability;Biological Markers;Blinded;Blood;Characteristics;CHI3L1 gene;Clinic;Clinical;Clinical Data;Clinical dementia rating scale;clinical diagnosis;clinical efficacy;Clinical Research;clinical research site;Clinical Trials;cohort;Conduct Clinical Trials;design;Diffusion;Disease;Disease Progression;DNA;Dose;Double-Blind Method;drug efficacy;Drug Kinetics;Drug Targeting;effective therapy;efficacy trial;Elements;Enrollment;Enzymes;follow-up;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Funding;Future;Generations;glial activation;Goals;imaging biomarker;Inflammatory;Infrastructure;inhibitor;International;Investigation;Laboratories;Light;limbic-predominant age-related TDP-43 encephalopathy;Liquid substance;Magnetic Resonance Imaging;Mass Spectrum Analysis;Measurement;Measures;Medical;Methodology;Modeling;Multi-Institutional Clinical Trial;Multicenter Trials;Nerve Degeneration;neurofilament;Neuronal Injury;Neuropsychological Tests;Neuropsychology;nonhuman primate;novel;Oral;Oral Administration;Oxidative Stress;Participant;Pathogenesis;Pathogenicity;Pathology;Patient Recruitments;Patients;Penetration;Pennsylvania;Peripheral;Peroxidases;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;Phase;phase II trial;Placebo Control;placebo controlled trial;Placebos;Plasma;pre-clinical;Primary Progressive Aphasia;programs;protein TDP-43;Proteins;proteomic signature;Proteomics;Randomized;Reagent;recruit;Research;Rodent;Role;Safety;safety testing;Semantics;Severities;Site;Syndrome;targeted treatment;Tars;therapeutic candidate;therapeutic development;therapeutic target;Therapeutic Trials;therapy development;United States National Institutes of Health;Universities;Variant

PROJECT_TITLE: Veri-T: A phase 1 Placebo-Controlled Trial of Verdiperstat in Semantic Variant Primary Progressive Aphasia Due to Underlying FTLD-TDP


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative This research project aims to better characterize the biological mechanisms involved in insulin resistance and their role in Alzheimer’s disease. The proposed research is relevant to public health as it is expected to provide new ways to prevent, delay or treat Alzheimer’s disease, by targeting insulin sensitivity. Thus, the project is relevant to the part of the NIH’s mission that pertains to improving fundamental knowledge that will help to reduce the burdens of complex human diseases such as Alzheimer’s disease.

PI_NAMEs: SARNOWSKI, CHLOÉ  (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Address;Aging;Alzheimer's Disease;Alzheimer's disease risk;Amyloid;apolipoprotein E-4;Apoptosis;Bioinformatics;Biological;Biological Markers;Biology;Blood;Blood - brain barrier anatomy;Brain;brain cell;brain health;Brain region;brain tissue;Bypass;career;career development;Cognition;Collaborations;Complex;Data;Dementia;design;DNA Methylation;Doctor of Philosophy;endophenotype;Environmental Risk Factor;Evaluation;experience;Failure;feature selection;Framingham Heart Study;Functional disorder;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Annotation;genetic resistance;Genetic Risk;genetic risk factor;Genetic study;genetic variant;genomic locus;Genomics;Glucose;Goals;Grant;human disease;Impaired cognition;improved;Individual;innovation;insight;instrument;Insulin;Insulin Resistance;insulin sensitivity;Joints;Knowledge;late life;Late Onset Alzheimer Disease;Machine Learning;Measures;Memory;Mendelian randomization;Mentorship;Methods;mild cognitive impairment;Mission;Molecular Profiling;multiple omics;Nerve Degeneration;Neurofibrillary Tangles;neuroimaging;novel;Obesity;Outcome;Pathogenesis;Pathway interactions;Patients;peripheral blood;Phase;Plasma;Predisposition;Prevalence;prevent;preventive intervention;Principal Investigator;programs;Public Health;religious order study;Research;Research Personnel;Research Project Grants;Risk Factors;Role;Scientist;Senile Plaques;Statistical Methods;tau Proteins;Techniques;Testing;Therapeutic Intervention;tissue resource;Tissues;tool;Training;trait;Trans-Omics for Precision Medicine;transcriptome sequencing;treatment response;United States National Institutes of Health;vascular risk factor;whole genome

PROJECT_TITLE: Exploring Common Biological Pathways Underlying Insulin Resistance and Alzheimer Disease using Genetic and Omic Tools


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Human Genome;Infectious Diseases;Liver Cancer;Liver Disease;Orphan Drug;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE Hepatitis B virus (HBV)-driven hepatocellular carcinoma (HCC) is among the most deadly cancers worldwide and disproportionally affects minority groups and immigrants in the US. We found 10% of HBV+ HCC tumors carry clonal integrations of HBV sequences in the KMT2B gene within the cancer genome, which affect about 35,000 HCC cases yearly. This project will investigate this understudied oncogenic event, discover how these integrations cause cancer, and provide novel targeted strategies to treat patients.

PI_NAMEs: CAO, JIAN  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: advanced disease;Affect;Alleles;Amino Acids;Animals;Automobile Driving;Binding;Binding Sites;Biochemical;Bioinformatics;C-terminal;Cancer Etiology;cancer genome;Cancer Histology;cancer site;cancer type;carcinogenesis;Cell Line;Cell Proliferation;Cells;Cessation of life;Chromatin;Chromosomal translocation;Chromosomes;chronic infection;Clinical;Complex;Data;detection assay;Development;Disease;Early Diagnosis;Enzymes;Epigenetic Process;Event;Exons;experience;gain of function;Gene Expression;Genes;Genetic Engineering;Genome;genome-wide analysis;genomic locus;Goals;Hepatitis B Infection;Hepatitis B Virus;Hepatocarcinogenesis;hepatocellular carcinoma cell line;Hepatocyte;histone demethylase;histone methyltransferase;histone modification;Histones;Homologous Gene;Hot Spot;Human;Image;Immigrant;In Vitro;in vivo;in vivo Model;Individual;Infant;inhibitor;Injections;insight;integration site;KDR gene;Knock-in;Knock-out;Lead;Length;lens epithelium-derived growth factor;leukemia;Liver;liver cancer model;Liver neoplasms;loss of function;Lysine;Malignant neoplasm of liver;Malignant Neoplasms;Measures;Methyltransferase;Minority Groups;Mixed-Lineage Leukemia;MLL gene;Modeling;Monitor;mouse model;Multiple Endocrine Neoplasia Type 1;mutant;Mutation;new therapeutic target;novel;Oncogenes;Oncogenic;Oncornaviruses;overexpression;Patients;pharmacologic;Phenotype;Phosphotransferases;Prevention approach;Preventive;Primary carcinoma of the liver cells;Protein Truncation;RNA-Directed DNA Polymerase;Tail;targeted agent;targeted treatment;Telomerase;Testing;Therapeutic;transcriptome sequencing;tumor;tumor growth;tumor initiation;Tumor Promotion;Tumor Suppressor Proteins;tumorigenesis;Variant;Vascular Endothelial Growth Factors;Veins;viral DNA;Virus Integration;whole genome

PROJECT_TITLE: Hepatitis B virus integrations in KMT2B drive hepatocellular carcinoma

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE This study will characterize the association between obstructive sleep apnea (OSA) and its treatment with cognitive decline and development of Alzheimer’s disease and related dementias (ADRD), and identify if these associations interact with other ADRD risk factors (e.g., cardiovascular disease) with regards to cognitive outcomes. The project will harmonize data from two long-running NIA-funded nationally representative cohort studies: the Health and Retirement Study (HRS) and the National Health and Aging Trends Study (NHATS), and will link these data to Medicare claims. Results from this study have the potential to a) identify how treatment of OSA may be a preventive measure for ADRD, and b) inform allocation of treatments to high-risk groups in order to promote preserved cognitive health in later life.

PI_NAMEs: KAUFMANN, CHRISTOPHER NORFLEET (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Address;Adherence;administrative database;African American population;age group;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Attention;Cardiovascular Diseases;cardiovascular risk factor;Caucasians;Clinical;Clinical Trials;Cognition;Cognitive;cognitive function;cognitive performance;cognitive testing;cohort;Cohort Studies;Continuous Positive Airway Pressure;Data;data harmonization;Data Set;Dementia;dementia risk;Development;Diagnosis;Disease;disorder risk;Education;effective therapy;Elderly;ethnic minority;Ethnic Origin;Exhibits;Female;follow-up;Funding;Gender;Health;Health and Retirement Study;health equity;high risk;high risk population;human old age (65+);Impaired cognition;improved;Individual;innovation;Investigation;late life;Link;Measures;Medicare claim;men;Methods;Observational Study;Obstructive Sleep Apnea;older adult;Outcome;Participant;Performance;performance tests;Persons;physical inactivity;Population;preservation;Prevalence;prevent;Prevention;Preventive measure;processing speed;Program Development;protective effect;racial minority;Resources;Risk;Risk Factors;Risk Reduction;Running;Sampling;Sleep Apnea Syndromes;Subgroup;tool;treatment disparity;trend;Visuospatial;Vulnerable Populations;Woman

PROJECT_TITLE: Sleep apnea treatment and risk for cognitive decline and Alzheimers disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(55)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Genetics;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Thyroid hormone plays an important role in early development and growth, and continues in adults to regulate oxidative metabolism, cardiac output, energy balance, fertility, CNS function, and others. The proposed project in this application will use a murine model to examine the adaptive responses and consequences of a complete lack of thyroglobulin (Tg), the main precursor protein for thyroid hormone synthesis. Successful completion of the proposed study will yield results relevant to our understanding of human congenital hypothyroidism, and will also be pivotal to my development as an independent scientist with interdisciplinary training in cell biology and physiology.

PI_NAMEs: YOUNG, KATHY CRYSTAL (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Adult;Affect;Alleles;Anabolism;Animal Disease Models;Animals;Apical;Automobile Driving;Behavior;Binding;Biochemical;Cardiac Output;Cause of Death;Cell Death;cell growth;Cell Physiology;Cell Respiration;Cells;Cellular biology;Cessation of life;Clinical;Cretinism;cytotoxic;cytotoxicity;Data;Detection;Development;Differentiated Gene;Digestion;Disease;driving force;Education;Endocrine system;Endoplasmic Reticulum;endoplasmic reticulum stress;energy balance;Environment;experience;extracellular;Fertility;Future;gene product;Genes;Genetic Transcription;Gland;Goiter;Growth;Growth and Development function;Human;Hydrogen Peroxide;Hypothyroidism;Image;Immunofluorescence Immunologic;interest;Invertebrates;Iodide Peroxidase;Iodination reaction;knockout animal;knockout gene;Knockout Mice;Life;Mediating;Messenger RNA;mouse model;Mus;mutant;Mutation;neutrophil;Pathway interactions;Patients;Peroxidases;Phenotype;Pituitary Gland;Play;Production;Proliferating;Protein Precursors;Proteins;Reporting;response;Role;Scientist;secretory protein;Side;spatial relationship;Surface;Techniques;Testing;Thyroglobulin;Thyroid Function Tests;Thyroid Gland;Thyroid Hormones;Thyrotropin;Thyroxine;tool;Toxic effect;trafficking;Training;Translations;Triiodothyronine;Vertebral column;Vertebrates;Western Blotting

PROJECT_TITLE: Adaptive Response(s) to Complete Thyroglobulin Gene Knockout

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Diabetes Endocrinology and Metabolic Diseases [DDK-E]