ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This project investigates alpha-synuclein fibril structures and how various factors contribute to fibril stability and aggregation, leading to diseased fibril states that are centrally implicated within several neurodegenerative diseases (Parkinson disease, Lewy body dementia, multiple system atrophy) affecting millions of people each year. Fibril structures will support efforts in the broader research community to develop diagnostic tools and eventual therapies for these neurodegenerative diseases. This proposed study aims to determine the structure of in vivo fibrils amplified from patient tissue, to measure the molecular dynamics and quaternary structures, and to detect the site-specific binding of imaging ligands with atomistic detail.

PI_NAMEs: BORCIK, COLLIN GRIFFIN (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Affect;Affinity;aggregation pathway;alpha synuclein;Amyloid;Binding;Binding Sites;Biophysics;Chad;Characteristics;Chemicals;clinical application;cognitive function;Collaborations;Communities;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Data;Development;Diagnosis;diagnostic development;diagnostic tool;Disease;disease phenotype;Environment;Etiology;Exhibits;experience;experimental study;Faculty;Fellowship;Fluorescent Dyes;Formulation;Future;graduate student;Grant;Imaging ligands;improved;In Vitro;in vivo;Infrastructure;insight;Institution;International;Joints;Label;Lansoprazole;Length;Lewy Body Dementia;Ligand Binding;Ligands;Location;Magnetic Resonance;Measures;meetings;member;Membrane Proteins;Mentors;Methodology;Methods;Molecular Conformation;molecular dynamics;Motor;Multiple System Atrophy;National Research Service Awards;Neurodegenerative Disorders;NMR Spectroscopy;novel;novel strategies;Parkinson Disease;Parkinson's Dementia;Pathogenicity;Pathology;Pathway interactions;Patients;Persons;Phenotype;Physiological;Pittsburgh Compound-B;Polymorph;Positron-Emission Tomography;Postdoctoral Fellow;preference;Preparation;Property;protein aggregation;Protein Dynamics;protein structure;Public Health;Publications;Relaxation;Research;Residual state;Resolution;Risk;Site;small molecule;solid state nuclear magnetic resonance;Spectrum Analysis;structural biology;Structure;synucleinopathy;Techniques;Technology;Temperature;Testing;Therapeutic;Tissues;tool;tool development;Training;Universities;Variant;Vertebral column;Water;Width;Wisconsin

PROJECT_TITLE: Structural Biology and Biophysics of Alpha-Synuclein Fibrils by Solid-State NMR


ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cystic Fibrosis;Infectious Diseases;Lung;Natural Products;Rare Diseases

ORG_CITY: PASADENA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

ORG_STATE: CA

PHR: Project Narrative The azetidine-containing metabolites azetidomonamide A, azetidopyridone, and diazetidomonapyridone have attracted recent interest due to their significance in biofilm and pigment production of the pathogenic bacterium Pseudomonas aeruginosa. Biological studies to understand the metabolites’ role in these bacterial quorum- sensing pathways have been hindered because the molecules are difficult to synthesize in significant quantities; this proposal seeks to establish their first chemical total syntheses. This project is relevant to the NIH’s mission because 1) in the short-term, it will expand current fundamental understanding in the synthesis of bioactive natural products, and 2) in the long-term, findings derived from biological studies of these metabolites could potentially lead to new anti-virulence treatments for those infected with P. aeruginosa.

PI_NAMEs: DORN, STANNA  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Address;adverse outcome;Affect;Alcohols;Alkenes;azetidine;Behavior;bioactive natural products;Biochemical Pathway;Biological;Biological Process;Biomimetics;Carbamates;career;chemical synthesis;Chemicals;Chemistry;Complex;Creativeness;Cyclization;cystic fibrosis patients;design;Development;Future;Geometry;Glycine;Goals;Health;Human;interest;Ions;Literature;member;Methodology;Methods;Microbial Biofilms;Mission;Modernization;Natural Products;novel;novel strategies;Organic Chemistry;Organometallic Chemistry;oxidation;Oxidation-Reduction;pathogenic bacteria;Pathway interactions;peptide synthase;Periodicity;Physical condensation;Pigments;Production;professor;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pyridones;quorum sensing;Reaction;Research;Risk;risk mitigation;Role;Route;scaffold;success;System;Training;Translating;United States National Institutes of Health;Variant;Virulence

PROJECT_TITLE: Strategies towards the Synthesis of Azetidine-Containing Metabolites Produced by Pseudomonas aeruginosa


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative c-Myc overexpressing large B-cell lymphoma (LBCL) have a significantly worse prognosis compared to the c- Myc-negative counterpart. Based on our preliminary data, we hypothesize that TBL1 serves as a critical modulator of c-Myc turnover and represents a novel and attractive candidate for targeted therapy for patients with c-Myc overexpressing LBCL. At completion of this project, we will have a better understanding of the TBL1-modulated mechanism through which c-Myc turnover is regulated, will have developed a novel therapeutic strategy (tegavivint) to treat this incurable disease, and will have begun to characterize resistance mechanisms to tegavivint.

PI_NAMEs: ALINARI, LAPO  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Accounting;Adaptor Signaling Protein;Address;B-Cell Lymphomas;B-Lymphocytes;BCL2 gene;BCL6 gene;beta catenin;c-myc Genes;CCND1 gene;Cell Death;Cell Survival;Cells;Cellular Morphology;Chromosomal translocation;Clinical;Complex;CRISPR screen;Data;Diffuse;Disease;disease model;Event;F Box Domain;FRAP1 gene;Genetic;Genetic Transcription;Immuno-Chemotherapy;Immunohistochemistry;Immunologics;In Vitro;in vivo;in vivo Model;inhibitor;Institution;Investigation;knock-down;Lead;Lymphoma;Lymphoma cell;Mediating;Methods;Molecular;multicatalytic endopeptidase complex;novel;novel strategies;novel therapeutic intervention;Oncogenic;Oncoproteins;Outcome;overexpression;Pathway interactions;Patients;Pattern;pharmacologic;Pharmacological Treatment;Phase Ib Trial;Play;posttranscriptional;potential biomarker;Pre-Clinical Model;predicting response;Prognosis;programs;Promoter Regions;protein expression;Protein Overexpression;Proteins;Proto-Oncogene Proteins c-myc;Publishing;recruit;Refractory;Relapse;Reporting;resistance mechanism;response;Role;Safety;Signal Transduction;small molecule;targeted treatment;Testing;Therapeutic;Transducin;WNT Signaling Pathway;Work

PROJECT_TITLE: Targeting c-Myc stability in c-Myc overexpressing large B-cell lymphoma

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: HG

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Modern biological methods can measure the expression of every gene at once, and scientists often use them ask how levels of different genes are changed in response to mutations, diseases, or other perturbations. Existing methods zoom in on individual genes with large expression changes, potentially missing small shifts across many or even all genes. We propose a new method to capture the overall, transcriptome-wide impact of a perturbation on gene expression, which has applicability to understanding both basic biology and diverse disease states.

PI_NAMEs: NADIG, AJAY  (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Affect;base;Biological;Biological Assay;Biology;Brain;Cell Line;Cell Physiology;Chromatin;Chronic Myeloid Leukemia;chronic myeloid leukemia cell;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Computational Biology;Computer software;Data;Data Set;differential expression;Disease;experimental study;Fellowship;functional genomics;Gene Cluster;Gene Deletion;Gene Expression;Gene Expression Profile;gene function;Genes;Genetic;Genetic Variation;Genome;genome-wide;Goals;Human;Human Genetics;improved;In Vitro;in vivo;Individual;insight;interest;knock-down;Literature;Malignant Neoplasms;Maps;Measures;Mentors;Mentorship;method development;Methodology;Methods;model building;Modeling;Modernization;Mus;Mutation;Neocortex;Neurodevelopmental Disorder;novel;open source;Parameter Estimation;Pathogenicity;Pathologic;Pattern;Phenotype;Repression;Research;response;risk variant;Scientist;Shapes;Signal Transduction;Statistical Methods;Stratification;Structure;Testing;tool;tool development;Training;transcriptome;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: The transcriptome-wide impact of biological perturbations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Digestive Diseases;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Enteric synucleinopathy is a major cause of gastrointestinal dysfunction and is believed to be the precursor of CNS synucleinopathies like Parkinson’s Disease (PD) and PD-Dementia. The immune system has been increasingly implicated in various stages of synucleinopathies and represents a promising therapeutic target in general. This study will investigate the role of gut-resident immune cells in enteric synucleinopathy to identify molecular mechanisms underpinning neuro-immune interactions that may influence disease progression.

PI_NAMEs: MACKIE, PHILLIP  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Adopted;Affect;Age;Aging;alpha synuclein;Antigen Presentation;Atlases;Automobile Driving;Autonomic Dysfunction;Biological Assay;Braak's hypothesis;Brain;brain pathway;Calcium;career;Cell Physiology;Cells;Central Nervous System;Complement;Dementia;Deposition;Development;Disease;Disease Progression;economic cost;Enteral;Etiology;Event;experimental study;Functional disorder;Future;gastrointestinal;gastrointestinal symptom;Genetic Transcription;Goals;Image;Immune;Immune response;Immune system;Impaired cognition;Inflammatory;Inflammatory Response;Injections;Intestines;Investigation;Lewy Body Dementia;Macrophage;Mediating;Microglia;Microscopy;Molecular;Morbidity - disease rate;motility disorder;motor disorder;mouse model;Movement Disorders;multi-photon;Myelogenous;Nerve;Nerve Degeneration;network dysfunction;Neurodegenerative Disorders;Neuroimmune;Neuronal Dysfunction;Neurons;neuropathology;neurophysiology;novel;Outcomes Research;Output;palliate;Parkinson Disease;Parkinson's Dementia;Pathogenesis;Pathology;Patients;Phagocytes;Phenotype;Phosphorylation;Physicians;Population;Prevalence;prevent;Prevention;Preventive treatment;Process;Resources;response;Rest;Risk Factors;Role;Scientist;Sentinel;single-cell RNA sequencing;Source;Synapses;synaptic pruning;synucleinopathy;T-Cell Activation;Testing;therapeutic candidate;therapeutic target;Time;Training;Translational Research;Vagus nerve structure;Work

PROJECT_TITLE: Investigating the role of myenteric macrophages in enteric synucleinopathy


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Rehabilitation

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Childhood cancer survivors treated with anthracycline chemotherapy or chest-directed radiation are at risk for cardiomyopathy. This study aims to validate advanced artificial intelligence methods to accurately identify survivors at high risk for cardiomyopathy using low-cost, accessible electrocardiography data and to evaluate the feasibility of using smartwatches for this purpose. Such artificial intelligence tools may facilitate early detection of high risk survivors who may benefit from advanced cardiac imaging and interventions to preserve cardiac function.

PI_NAMEs: AKBILGIC, OGUZ  (contact);HUDSON, MELISSA M

PROGRAM_OFFICER_NAME: SHELBURNE, NONNIEKAYE F

PROJECT_TERMS: Academic Medical Centers;Adult;Algorithms;Anthracycline;Artificial Intelligence;artificial intelligence method;Cancer Survivor;Cancer Survivorship;cancer type;Cardiac;Cardiology;Cardiomyopathies;Cardiovascular system;Characteristics;chemotherapy;Chest;Childhood;childhood cancer survivor;Clinical;cohort;Cohort Studies;Communities;Coronary Arteriosclerosis;cost;Data;deep learning;demographics;Development;Diagnosis;digital;Dose;Drops;Early Diagnosis;Early identification;Echocardiography;EFRAC;Electrocardiogram;Epidemiology;feature extraction;feature selection;follow-up;Functional disorder;Future;Goals;gradient boosting;Guidelines;Health;Heart failure;heart function;heart imaging;Heart Injuries;heart preservation;Heart Valve Diseases;high risk;improved;Intervention;Lead;Left Ventricular Ejection Fraction;Left Ventricular Remodeling;Life;Machine Learning;Malignant Childhood Neoplasm;Measures;Modality;Modeling;Morbidity - disease rate;Myocardial;Myocardial dysfunction;novel;novel strategies;Participant;Patients;Pediatric Hospitals;Pediatric Oncology;Pediatric Oncology Group;Performance;predictive modeling;predictive tools;preservation;prevent;primary outcome;Quality of life;Radiation;Recommendation;Research;Research Personnel;Risk;risk prediction;risk stratification;Saint Jude Children's Research Hospital;Screening for cancer;screening guidelines;secondary outcome;Shapes;signal processing;smart watch;Specificity;Subgroup;Supportive care;Survival Rate;Survivors;Technology;Testing;Time;tool;Treatment-Related Cancer;tumor progression;Validation;Visit;Work

PROJECT_TITLE: Early Identification of Childhood Cancer Survivors at High Risk for Late Onset Cardiomyopathy: An Artificial Intelligence Approach utilizing Electrocardiography


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE NCI-sponsored clinical trials are essential to improve the prevention, detection, and treatment of cancer. While highly trained and productive clinical trialists are needed to develop, initiate, and manage these trials, competing responsibilities often limit their contribution to these efforts. Support fromthe R50 will allow Dr. Jonas to continue his development as a leader in NCI-sponsored clinical trial activities and ultimately improve the lives of patients with acute leukemia and myelodysplastic syndromes (MDS).

PI_NAMEs: JONAS, BRIAN A. (contact)

PROGRAM_OFFICER_NAME: LINDWASSER, ONN WOLF

PROJECT_TERMS: Acute leukemia;Acute Lymphocytic Leukemia;American College of Radiology Imaging Network;Award;Biological Markers;California;cancer care;cancer clinical trial;cancer therapy;Cancer Therapy Evaluation Program;Clinical;Clinical Research;Clinical Treatment;clinical trial implementation;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;Comprehensive Cancer Center;Data;Dedications;design;Detection;Development;Disease;Doctor of Philosophy;Dysmyelopoietic Syndromes;Eastern Cooperative Oncology Group;Educational process of instructing;Growth;Hematologic Neoplasms;Hematology;Heme;improved;Individual;Institution;Investigational Therapies;Leadership;leukemia;leukemic stem cell;Malignant Neoplasms;member;mid-career faculty;Monitor;multidisciplinary;National Clinical Trials Network;novel;Oncology;Oncology Group;Participant;Patients;Prevention;Productivity;programs;Qualifying;Research;Safety;Scientist;Services;Shapes;Southwest Oncology Group;Specialist;Therapeutic;therapeutic target;Time;Training;translational study;working group

PROJECT_TITLE: NCI R50 Clinician Scientist Award


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Congenital Structural Anomalies;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative Secretory protein trafficking enables newly synthesized proteins to be transported to the cell surface. Faulty trafficking is implicated in developmental defects in brain development; however, how defective trafficking causes abnormal brain development is unknown. This work aims to elucidate how inefficient protein trafficking leads to brain birth defects and abnormal neuronal differentiation using rare disease patient-derived cell models.

PI_NAMEs: AHN, LUCIE YEONGRAN (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: 3-Dimensional;Affect;Age;anterograde transport;Biogenesis;Birth;Brain;brain abnormalities;brain malformation;Calnexin;Cell Death;Cell Line;Cell model;Cell Physiology;Cell Proliferation;Cell surface;cell type;Cells;Centrioles;cerebral atrophy;Cerebral cortex;Cerebrum;Child;Childhood;Clinical;comparison control;Congenital Abnormality;CRISPR/Cas technology;Cytokinesis;Data;Defect;Development;disease model;disease-causing mutation;DNA Damage;Endoplasmic Reticulum;exome sequencing;Gender;gene correction;Generalized Epilepsy;Genes;Genetic;genetic variant;genome sequencing;Golgi Apparatus;Head circumference;Hela Cells;Homologous Gene;Human;In Vitro;induced pluripotent stem cell;inhibitory neuron;insight;knock-down;Knock-out;Link;Membrane;Microcephaly;Mitosis;Molecular;morphogens;Mutation;neonatal diabetes mellitus;nerve stem cell;neural;Neural tube;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;neuron development;Neuronal Differentiation;Neuronal Dysfunction;Neurons;neuroregulation;Online Mendelian Inheritance In Man;Organoids;patched protein;Pathogenesis;Pathogenicity;Pathway interactions;patient - derived stem cells;patient derived induced pluripotent stem cells;Patients;Pattern;Phenocopy;Phenotype;Process;Protein Biosynthesis;protein expression;protein transport;Proteomics;proteostasis;Rare Diseases;receptor;Reporter;Reporting;Research;response;Role;Scientist;secretory protein;SHH gene;sonic hedgehog receptor;Specific qualifier value;stem cell population;Structural Congenital Anomalies;Syndrome;Technology;Testing;tool;trafficking;United States;Variant;Vesicle;Work;Yeasts

PROJECT_TITLE: Dissecting the role of IER3IP1 in neurogenesis and brain malformation


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Changes in the copy number of large genomic regions, termed CNVs, contribute to the phenotypic variation of many cell types and organisms. Understanding how these changes arise will lead to advances in our ability to tackle a range of public health challenges including antimicrobial resistance, cancer progression, and neural degeneration.

PI_NAMEs: GULER, JENNIFER LYNN (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Anti-malarials;Antimicrobial Resistance;asexual;AT Rich Sequence;Bacteria;base;Biology;Blood;cell type;Characteristics;Chromosomes;Clinical;Comparative Study;Copy Number Polymorphism;density;Detection;Disease Progression;DNA;Drug resistance;emerging human pathogen;Environment;Evaluation;Event;Evolution;Exhibits;experimental study;Frequencies;Future;GC Rich Sequence;Generations;Genes;Genome;genome-wide;Genomic Segment;Genomics;Haploidy;Human;improved;In Vitro;in vivo;Individual;Intercistronic Region;Knowledge;Laboratories;Malaria;Malignant Neoplasms;Maps;Measures;Methods;microbial disease;microorganism;Modeling;Mutation;Nature;Nerve Degeneration;novel;Organism;parasite genome;Parasites;pathogenic microbe;Pathway interactions;Pharmacotherapy;Phenotype;Physiological;Plants;Plasmodium;Plasmodium falciparum;Plasmodium falciparum genome;Plasmodium genome;Plasmodium vivax;Population;Positioning Attribute;pressure;Process;Proteins;Protozoa;Public Health;repaired;Research;Resolution;Signal Transduction;single cell genomics;Site;Source;Stress;Testing;Time;tool;tool development;tumor progression;Variant;Yeasts

PROJECT_TITLE: The evolution of copy number variations in the AT-rich Plasmodium genome

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Radiation Oncology

ORG_CITY: OMAHA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Relevance: The neurotensin receptor subtype 1 (NTSR1) is expressed in a large segment of colorectal cancers. By incorporating irreversible inhibitors into NTSR1-targeted agents, we seek to develop a targeted radionuclide therapeutic that can form high-molecular-weight intracellular adducts. By this approach, our developed therapeutic agents will demonstrate significantly higher radiation dose delivery and therapeutic efficacy for colorectal cancer patients.

PI_NAMEs: GARRISON, JERED C (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: Address;adduct;analog;Anatomy;Binding;Biodistribution;Biological;Biology;Cancer Etiology;Caspase;Cessation of life;Chemicals;chemotherapy;Clinical;clinical translation;colon cancer patients;Colon Carcinoma;Colorectal Cancer;colorectal cancer treatment;comparative efficacy;Cysteine Proteinase Inhibitors;Data;design;Development;Diagnosis;Disease;Dose;dosimetry;Drug Kinetics;Drug or chemical Tissue Distribution;effective therapy;Effectiveness;efficacy study;Evaluation;Exclusion;Exhibits;External Beam Radiation Therapy;extracellular;Fluorouracil;Goals;Grant;Health;HT29 Cells;Human;improved;In Vitro;in vitro testing;in vivo;inhibitor;innovation;Investigational Drugs;Kidney;Label;Laboratories;Lead;Malignant Neoplasms;Maximum Tolerated Dose;meetings;Membrane;Metabolic Clearance Rate;metastatic colorectal;microautoradiography;Modeling;Molecular Weight;mouse model;Neurotensin Receptors;New Drug Approvals;novel strategies;Operative Surgical Procedures;overexpression;Pathway interactions;patient derived xenograft model;patient population;Peptide Hydrolases;Performance;Property;Protease Inhibitor;protein expression;Proteomics;Radiation Dose Unit;Radiation therapy;Radiation Tolerance;Radiation-Sensitizing Agents;Radionuclide therapy;receptor;Research Design;residence;Residual Neoplasm;Skin Cancer;standard of care;Structure;Structure-Activity Relationship;targeted agent;targeted radiotherapeutic;targeted treatment;Technology;Therapeutic;Therapeutic Agents;therapeutic evaluation;therapeutically effective;Time;Tissues;Toxic effect;Treatment Efficacy;tumor;Tumor Markers;Xenograft procedure

PROJECT_TITLE: Development of an NTSR1-Targeted Radiotherapeutic for Colorectal Cancer

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biotechnology;Cancer;Lung;Lung Cancer

ORG_CITY: BATON ROUGE

ORG_DEPT: PATHOLOGY

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Narrative: The project involves designing a grafted peptide molecule from a plant-based peptide, which can be used to modulate protein-protein interactions of EGFR proteins that are overexpressed or mutated in lung cancer. The research outcomes from this project will help in developing therapeutic grafted peptides that could have an impact on lung cancer that becomes resistant to treatment. These grafted peptides will form the basis of a new therapeutic approach to NSCLC that could improve the survival rate of lung cancer patients.

PI_NAMEs: BILLADEAU, DANIEL D;JOIS, SEETHARAMA D (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Animal Cancer Model;Antibodies;Automobile Driving;Binding;Biological Availability;Biological Products;cancer cell;Cancer cell line;Cancer Patient;cancer therapy;cancer type;Cell model;Chemicals;Clinical;Cyclic Peptides;design;Development;dimer;Dimerization;disulfide bond;Drug Kinetics;Drug Targeting;Epidermal Growth Factor Receptor;ERBB3 gene;Exhibits;Extracellular Domain;Family;functional group;Gene Amplification;Generations;Genetic;Goals;Growth;Heterodimerization;Homo;Human;humanized antibody;humanized monoclonal antibodies;improved;In Vitro;in vitro Model;in vivo;inhibitor;Intestines;Knowledge;Lead;lung cancer cell;Lung Neoplasms;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Modeling;Molecular;Mus;mutant;Mutate;Mutation;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;Oral;Outcomes Research;overexpression;Pathologist;Pathway interactions;patient derived xenograft model;patient subsets;Patients;peptide drug;Peptides;peptidomimetics;Periodicity;Pertuzumab;Pharmacologic Substance;Phosphotransferases;Plants;Play;prevent;Process;Property;Protein Inhibition;Protein Overexpression;protein protein interaction;Proteins;receptor;Reporting;Research;Research Project Grants;Resistance;Resistance development;Role;Scientist;Signal Pathway;Signal Transduction;small molecule;Specificity;stability testing;Structure;Sunflowers;Survival Rate;targeted treatment;Therapeutic;Therapeutic Agents;Therapeutic Effect;therapeutic target;therapy resistant;Trypsin Inhibitors;tumor;tumor growth;tumor progression;Tyrosine Kinase Inhibitor;Variant;Xenograft Model

PROJECT_TITLE: Molecular mechanism of EGFRs protein-protein interaction inhibition by a grafted peptide in NSCLC

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Chronic Pain;Clinical Research;Endocannabinoid System Research;Mental Health;Neurosciences;Opioids;Pain Research;Patient Safety;Pediatric;Social Determinants of Health;Therapeutic Cannabinoid Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Children are often prescribed opioid analgesic medications to use at home following surgical procedures. This study evaluates the complex interaction between biological, psychological, and social influences which may drive opioid use in children following surgery. With a specific focus on parents as the gatekeeper for children’s medication use, data gathered will help inform the development of preoperative interventions and predictive models to optimize opioid use for pediatric postsurgical pain.

PI_NAMEs: STONE, AMANDA LEIGH (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: 2-arachidonylglycerol;Acute Pain;Address;Adenoidectomy;Adolescence;Adult;aged;Analgesics;anandamide;Anxiety;Belief;Biological;Biological Factors;biopsychosocial;biopsychosocial factor;Blood;career development;Caring;Child;Childhood;chronic pain;Clinical;clinical development;Collaborations;Collection;Complex;coping;Data;Dehydration;design;Development;diaries;Electronics;Emergency department visit;Emotional;Emotions;Endocannabinoids;endogenous opioids;experience;follow up assessment;follow-up;Frequencies;Gatekeeping;Guidelines;Health Care Costs;Home;hospital readmission;Iatrogenesis;improved;innovation;Instruction;Interdisciplinary Study;Intervention;Joints;Leadership;Measures;medication administration;Mentored Patient-Oriented Research Career Development Award;Modeling;Nausea;negative affect;novel;Only Child;Operative Surgical Procedures;Opioid;Opioid Analgesics;opioid disposal;opioid misuse;opioid policy;opioid use;Outcome;Pain;Pain intensity;Pain management;pain outcome;pain relief;Parent-Child Relations;parental influence;Parents;Patient Education;Pattern;pediatric patients;Pediatric Surgical Procedures;Pharmaceutical Preparations;Postoperative Pain;Postoperative Period;Practice Management;predictive modeling;Predisposition;prescription opioid;Procedures;Process;programs;prospective;Provider;psychologic;Psychological Factors;psychosocial;Psychosocial Factor;Quality of life;Recording of previous events;Research;Research Personnel;respiratory;response;Risk;risk mitigation;screening;Self Efficacy;Severities;side effect;skills;social factors;social influence;Standardization;Statistical Models;Subgroup;Surveys;Telephone;Testing;therapy development;Time;Tissues;Tonsillectomy;Training;Uncertainty;Ventilatory Depression;young adult;Youth

PROJECT_TITLE: Biopsychosocial predictors of opioid use for pediatric postsurgical pain

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Digestive Diseases - (Gallbladder);Genetics;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Intrahepatic cholangiocarcinoma (ICC) is a highly lethal form of liver cancer due to late diagnosis and limited therapeutic options. Through unbiased high-throughput drug screens we have identified a striking therapeutic vulnerability of ICC tumors harboring mutations in the isocitrate dehydrogenase (IDH), which make up the most common genetic subset. Using this discovery, this proposal aims to elucidate the specific molecular pathways driving the growth and survival of these tumors in order to better understand their unique biology and develop more effective therapeutic options for this disease.

PI_NAMEs: KUGEL, SITA  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Ablation;Affect;alpha ketoglutarate;anti-cancer research;Area;Automobile Driving;Basic Science;Binding;Biochemical;Biological Models;Biology;Cancer cell line;Cell Differentiation process;Cell Line;Cell Size;Cell Survival;Cells;chemotherapy;Cholangiocarcinoma;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Combination Drug Therapy;combinatorial;Complex;cost effective measures;CRISPR/Cas technology;Dasatinib;Data;Dependence;Diagnosis;Dioxygenases;Disease;Disease remission;early phase clinical trial;efficacy evaluation;Environment;Enzymes;Epigenetic Process;experimental study;falls;Family;FRAP1 gene;gain of function;Genes;Genetic;Genetic study;Genetic Transcription;genome editing;Goals;Growth;Hepatocyte;high-throughput drug screening;histone demethylase;histone methylation;HNF4A gene;Human;Human Cell Line;Hypersensitivity;improved;In Vitro;in vivo;Incidence;Induction of Apoptosis;inhibitor;Intrahepatic Cholangiocarcinoma;Isocitrate Dehydrogenase;kinase inhibitor;Laboratories;Liver Stem Cell;loss of function;Lysine;Maintenance;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;Messenger RNA;Modeling;Molecular;Molecular Biology;Molecular Profiling;Mus;mutant;Mutation;neoplastic cell;Newly Diagnosed;novel;novel therapeutic intervention;Oncogenic;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;phosphoproteomics;Phosphorylation;pill;Play;Polyribosomes;Prevention;Primary Malignant Neoplasm of Liver;Production;Prognosis;programs;Protein Dephosphorylation;Protein phosphatase;Proteins;Reagent;repository;Research Institute;response;Ribosomal Protein S6 Kinase;Ribosomes;Role;screening;side effect;src-Family Kinases;standard of care;stem cells;Structure;System;targeted treatment;Technology;Testing;Therapeutic;therapeutically effective;transcription factor;transcriptomic profiling;Translational Research;Translations;tumor;tumorigenesis;Work

PROJECT_TITLE: Exploring novel SRC-regulated pathways in IDH mutant intrahepatic cholangiocarcinoma

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: PHARMACOLOGY

PHR: The proposed research employs an emerging drug discovery technology, PROTAC, coupled with an innovative concept of E3 ligase based tissue specific induction of target protein degradation, to overcome the dose-limiting thrombocytopenia associated with inhibition of Bcl-xL in platelets. This could lead to a breakthrough in developing cancer therapies targeting Bcl-xL protein.

PI_NAMEs: KONOPLEVA, MARINA Y;ZHENG, GUANGRONG  (contact);ZHOU, DAOHONG

PROJECT_TERMS: Acute Myelocytic Leukemia;Acute T Cell Leukemia;Adverse effects;analog;anti-cancer;Antineoplastic Agents;Apoptosis;Apoptotic;asparaginase;bcl-xlong protein;BCL2 gene;BCL2L1 gene;Biological Assay;Blood Platelets;cancer cell;Cancer Relapse;cancer therapy;cancer type;Chemoresistance;chemotherapy;Chemotherapy and/or radiation;Chronic Lymphocytic Leukemia;Clinic;clinical application;Clinical Trials;clinically relevant;Coupled;Cytometry;Data;Dependence;design;Development;Dexamethasone;Dose Limiting;Doxorubicin;drug discovery;Drug Kinetics;Drug resistance;efficacy evaluation;Evaluation;Exhibits;Formulation;Goals;Human;improved;In Vitro;in vitro Assay;in vivo;in vivo evaluation;inhibitor;innovation;Lead;leukemia;Leukemia Acute Lymphoblastic Chemotherapy;Ligands;Malignant Neoplasms;MCL1 gene;Mediating;mouse model;Mus;Names;Neoplasm Metastasis;novel;novel strategies;patient derived xenograft model;Patients;Pharmaceutical Preparations;Play;Positioning Attribute;preclinical efficacy;prevent;Property;Protac;protein degradation;Protein Family;Proteins;recruit;Refractory;Relapse;Research;Resistance;Role;scale up;senescence associated secretory phenotype;senescent cell;senolytics;Series;small molecule;Specificity;standard of care;success;targeted cancer therapy;targeted treatment;Techniques;Technology;Testing;Therapeutic;Thrombocytopenia;Tissues;Toxic effect;Treatment Efficacy;tumor;tumor initiation;tumor xenograft;ubiquitin-protein ligase;Vincristine;Water

PROJECT_TITLE: Inhibition of Bcl-xL by Targeted Degradation


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This training program for 8 PhD students and 4 postdoctoral fellows in Molecular and Cellular Basis of Infectious Diseases (MCBID) is highly relevant to national interests in the areas of emerging infectious diseases. Training is focused on the molecular aspects of pathogen biology, disease pathogenesis, vectors of pathogen transmission and disease ecology. Overall emphasis is on rigorous scientific methods and practice with broad interdisciplinary perspectives.

PI_NAMEs: CASADEVALL, ARTURO  (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: The Molecular and Cellular Basis of Infectious Diseases (MCBID) Program

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Rare Diseases

ORG_CITY: BERKELEY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Our proposal investigates molecular mechanisms through which cells adhere to and migrate in/on hyaluronic acid (HA)-based extracellular matrices, with a focus on the membrane receptor CD44. In addition to developing fundamental new insight into HA/CD44-based adhesion, we will apply a variety of model systems to investigate how aberrant HA/CD44 adhesion contributes to the progression of malignant brain tumors.

PI_NAMEs: KUMAR, SANJAY  (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: 3-Dimensional;Actins;Address;Adhesions;Affect;Benchmarking;Biocompatible Materials;Biological;Biological Models;Biology;Biophysical Process;Biophysics;Biopsy;Brain;Brain Neoplasms;brain parenchyma;Brain Pathology;brain tissue;Cancer Biology;CD44 gene;Cell Adhesion;cell motility;Cell Shape;Cells;Chromosome Mapping;Collaborations;Collagen;comparative;Complex;Coupled;Cues;Cytoskeleton;Defect;Deposition;Development;Diffuse;Digestion;Disease;Dissection;Engineering;Excision;Extracellular Matrix;Extracellular Matrix Proteins;fabrication;Fibronectins;Filopodia;Glioblastoma;Homeostasis;Human;Hyaluronic Acid;Hyaluronidase;Hydrogels;in vivo;Infiltration;innovative technologies;insight;Institution;Integrins;interest;Invaded;Laboratories;Lasers;Ligands;Ligation;Malignant neoplasm of brain;Maryland;mechanical drive;mechanical signal;Mechanics;Mediating;Membrane;Microfluidics;Microtubules;migration;mimetics;Modeling;Molecular;Molecular Target;Molecular Weight;Motility;mouse model;nanosurgery;neoplastic cell;network architecture;neurogenesis;Neurosurgeon;neurosurgery;new therapeutic target;novel therapeutics;Operative Surgical Procedures;overexpression;Paper;Pathway interactions;Patients;Physiology;Play;Polysaccharides;Process;Property;protein expression;Proteomics;receptor;Regional Anatomy;Research Personnel;Role;Sampling;Scientist;Seminal;Site;stem;Stromal Cells;Structure;Study models;superresolution imaging;System;Testing;therapy resistant;three dimensional structure;Time;tissue mapping;Tissues;transmission process;tumor;Tumor Cell Invasion;Tumor Cell Migration;Variant;viscoelasticity;Viscosity;white matter;Work

PROJECT_TITLE: Mechanisms of adhesion and invasion in hyaluronic acid matrices

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Immunotherapy;Nanotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Urologic Diseases

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Narrative The single molecule sensitivity of solid-state nanopores make them ideal candidates for the detection of low abundance protein biomarkers in portable device formats. To realize this potential requires techniques for the concentration of protein biomarkers and lossless transfer to nanopores for single molecule counting. This project will combine advances in nanopore sensor design with precision microﬂuidics and on-chip biomarker pre-concentration to achieve low- abundance biomarker detection in a compact, purely electrical, device. The project will validate our developments through comparisons to gold standard quantiﬁcation of a cytokine panel in urine and a traumatic brain injury panel in blood.

PI_NAMEs: FLAX, JONATHAN D;GODIN, MICHEL ;MCGRATH, JAMES L (contact);TABARD-COSSA, VINCENT

PROGRAM_OFFICER_NAME: MULVANEY, SHAWN PATRICK

PROJECT_TERMS: Affinity Chromatography;Bacillus;BCG Live;Benchmarking;Binding;Biological Assay;Biological Markers;biomarker panel;Blood;Brain Injuries;Calibration;cancer immunotherapy;cancer therapy;clinically relevant;Complex;cost;cost effective;Coupled;current pandemic;cytokine;design;Detection;detector;Development;Devices;Diagnosis;Diagnostic;diagnostic platform;digital;DNA;Electron Microscopy;electronic sensor;Electronics;Emergency Department patient;enhancing factor;Ensure;Enzyme-Linked Immunosorbent Assay;fabrication;FDA approved;Geometry;Glial Fibrillary Acidic Protein;head-to-head comparison;Hour;IL8 gene;Immunoassay;Immunotherapy;Injury;instrument;Interleukin-2;Interleukin-6;invention;Label;Life;magnetic beads;Magnetism;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measurement;Measures;Membrane;meter;Methods;Microfluidic Microchips;Microfluidics;Microspheres;miniaturize;Modeling;Molecular;molecular diagnostics;nanoGold;nanomembrane;nanoparticle;nanopore;Nanoporous;Nanostructures;Nervous System Trauma;next generation;Nomograms;non-muscle invasive bladder cancer;novel;operation;Optics;Patients;Performance;point of care;point-of-care diagnostics;portability;Positioning Attribute;predicting response;predictive marker;Process;protein biomarkers;Proteins;Proxy;Public Health;Resource-limited setting;response;Sampling;Scheme;sensor;Serum;Signal Transduction;Silicon;silicon nitride;single molecule;Single-Stranded DNA;solid state;System;Techniques;TNF gene;Translating;Traumatic Brain Injury;UCHL1 gene;Ultraviolet Rays;Urine;Work

PROJECT_TITLE: Solid-state nanopores and silicon nanomembranes for ultrasensitive protein biomarker detection

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: DETROIT

ORG_NAME: JOHN D DINGELL VA MEDICAL CENTER

ORG_STATE: MI

PHR: Sensory hair cell synapses are critical for acoustic signal conduction from sensory hair cells to auditory neurons, but knowledge of hair cell synapse regeneration is very limited. This proposal will use both in vitro and in vivo animal models to investigate the molecular mechanisms critical for stem cell-derived neurons to reinnervate sensory hair cells. Completion of this project will significantly advance knowledge of hair cell synapse regeneration, which will potentially open new avenues to develop stem cell-based hair cell reinnervation approaches for Veteran and civilian hearing loss patients.

PI_NAMEs: HU, ZHENGQING  (contact)

PROJECT_TERMS: Acoustics;Affect;American;Animal Model;Auditory;Binding Proteins;Cell Culture Techniques;Cells;Clinical Trials;Cochlea;Coculture Techniques;conditional knockout;Data;Denervation;design;Development;embryonic stem cell;Ephrin B Receptor;Ephrin Receptor EphB1;Ephrins;Epigenetic Process;Family;functional restoration;Future;Genes;Goals;hair cell regeneration;Hair Cells;Hearing;hearing impairment;Hearing problem;hearing restoration;In Vitro;in vivo;insight;interdisciplinary approach;Knockout Mice;Knowledge;Labyrinth;Membrane;Methods;Modeling;Molecular;Mouse Embryonic Stem Cells;Mus;MYO7A gene;myosin VI;Natural regeneration;nerve stem cell;neural;neuron regeneration;Neurons;Neurophysiology - biologic function;novel;Outcome;Patients;Pilot Projects;Play;postnatal;programs;protein expression;Protein Family;Proteins;Publishing;Receptor Protein-Tyrosine Kinases;regeneration function;Regenerative research;reinnervation;Reporting;ribbon synapse;Role;self-renewal;Sensory Hair;Signal Transduction;sound;Source;spiral ganglion;stem cell based approach;stem cells;Synapses;synaptogenesis;Testing;Translating;Translational Research;Transplantation;Veterans;Work

PROJECT_TITLE: Developing novel stem cell-based approaches to treat hearing loss

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


FUNDING_MECHANISM: OTHERS

ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: The VA has had considerable success in reducing the number of homeless Veterans through permanent supportive housing programs. Permanent housing is necessary, however, but not sufficient for successful social integration. Poor social integration is associated with a variety of adverse mental and physical health outcomes. Notably, Black Veterans are overrepresented among homeless Veterans yet remain understudied in psychological science. A better understanding of potential racial differences in risk and protective mechanisms of social integration is crucial for the development of culturally responsive rehabilitative interventions for recently housed Veterans. The proposed study aims to examine the contributions of stress, inflammation, and resilience to social integration in recently housed Black and White Veterans. Knowledge gained can inform innovative race-conscious treatments that mitigate the effects of stress and enhance resilience to improve social integration in recently housed Veterans.

PI_NAMEs: NOVACEK, DEREK MATTHEW (contact)

PROJECT_TERMS: Accounting;Address;Area;Attention;Award;Black American;Black race;Buffers;California;career;Chronic stress;clinical center;Community Integration;Conflict (Psychology);Conscious;Consultations;Coping Skills;Data;Development;Disadvantaged;Doctor of Philosophy;Education;Environment;Exclusion;experience;Family;Frequencies;Friends;Goals;health disparity;Healthcare Systems;Homeless persons;Homelessness;Housing;improved;Inequity;Inflammation;inflammatory marker;Inflammatory Response;Infrastructure;innovation;Intervention;Joints;K-Series Research Career Programs;Knowledge;Life;Literature;Longitudinal Studies;Los Angeles;marginalization;Mental disorders;Mental Health;Mentors;Methods;military veteran;Modeling;multimodality;novel;Outcome;physical conditioning;poor health outcome;Population;programs;promote resilience;protective factors;psychiatric symptom;psychologic;Psychologist;Psychosocial Stress;Race;racial difference;racial health disparity;Rehabilitation therapy;Research;Research Personnel;resilience;Risk;Risk Factors;Role;Sampling;Science;Shelter facility;social;Social Behavior;social contact;social determinants;social integration;Social support;Stress;stress management;stress resilience;stressor;success;sugar;supported housing;Training;trait;treatment center;Universities;Veterans;Washington;Withdrawal;Work

PROJECT_TITLE: Chronic Stress, Inflammation, and Resilience: Predictors of Social Integration in Recently Housed Black and White Veterans

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

ORG_STATE: PA

PHR: This work will benefit both Veterans and civilians who have osteoarthritis, by developing a novel approach to reduce harmful inflammation in the joint after an injury, and prevent the onset of post-traumatic osteoarthritis and associated disability. The number of patients in the US estimated to have symptomatic osteoarthritis approaches 27 million. Incidence rate is 26% higher in active duty service members 20-24 years old, and >100% higher for those >40 years old, than the general population. This is largely due to increased incidence of acute and chronic joint injury in the military. This project will identify a novel method of treatment to inhibit inflammation that contributes to arthritis development and joint dysfunction after joint injury. Expanding medical approaches for OA and joint injuries will improve quality of life, enhance rehabilitative efforts, and diminish the need for joint replacement in Veterans.

PI_NAMEs: SCANZELLO, CARLA ROSE (contact)

PROJECT_TERMS: Acceleration;Accounting;active duty;Acute;Adrenal Cortex Hormones;anakinra;Animal Model;Animals;Anti-Inflammatory Agents;Antibodies;Arthritis;attenuation;Bilateral;Biological Markers;Biological Sciences;biomarker validation;Blocking Antibodies;career;Cartilage;CD14 Antigen;CD14 gene;Chronic;chronic pain;Clinical;clinical care;clinical development;clinical predictors;Clinical Trials;clinically relevant;cofactor;Contralateral;cost;Coupled;Cumulative Trauma Disorders;Data;Degenerative polyarthritis;Development;Devices;disability;Disabling;Disease;Disease Progression;Dose;Drug Delivery Systems;economic impact;efficacy testing;Emulsions;Encapsulated;Enzyme-Linked Immunosorbent Assay;Euthanasia;Family suidae;functional decline;Functional disorder;functional outcomes;Funding;Future;General Population;Genetic;Histopathology;Human;Image;Imaging Techniques;immunoregulation;improved;In Vitro;in vivo imaging system;Incidence;Infection;Inflammation;Inflammatory Response;Injections;Injury;Innate Immune Response;innovation;joint destruction;joint function;joint inflammation;joint injury;Joints;Knee;Knee Injuries;Knee joint;Knee Osteoarthritis;Laboratories;Limb structure;Linear Regressions;Link;Liquid Chromatography;Magnetic Resonance Imaging;Measures;Mechanics;Medial meniscus structure;Mediating;Medical;Methods;Microcapsules drug delivery system;Microfluidics;Military Personnel;military service;Miniature Swine;Modeling;Modification;Molecular;Monoclonal Antibodies;motion sensor;mouse model;multiplex assay;Mus;novel;novel strategies;novel therapeutics;Operative Surgical Procedures;osteoarthritis pain;Outcome;Pain;Participant;participant enrollment;Pathology;Pathway interactions;Patient Selection;patient stratification;Patients;Pattern recognition receptor;Performance;Pharmaceutical Preparations;pharmacologic;Physical activity;Physical Function;Placebos;Prediction of Response to Therapy;Prevalence;prevent;Process;Protocols documentation;Quality of life;receptor;Receptor Activation;Recovery of Function;Regression Analysis;Rehabilitation therapy;Replacement Arthroplasty;residence;response;Risk;Sampling;Serum;service member;Severities;Severity of illness;Side;side effect;socioeconomics;Standardization;symptom treatment;synergism;Synovial Fluid;Synovitis;tandem mass spectrometry;Technology;Testing;Therapeutic;therapeutic development;Time;tissue injury;Tissues;Toll-Like Receptor Pathway;Toll-like receptors;Traumatic Arthropathy;treatment effect;treatment response;Veterans;wearable device;Work

PROJECT_TITLE: Achieving Sustained Control of Inflammation to Prevent Post-Traumatic Osteoarthritis (PTOA)

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

PHR: Narrative SARS COV2 infection leads to significant morbidity and mortality. The major point of entry for the viral infection is the mouth and nose but little is known about how the immune cells in these areas interact with and responds to SARS COV. Improving understanding of which cells are affected and how the virus triggers inflammatory response in them is critical for SARS COV2 management and treatment.

PI_NAMEs: DIAMOND, GILL ;GLOVER, SARAH C (contact);HORWITZ, BRUCE H.

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: 2019-nCoV;3-Dimensional;ACE2;Acute;Address;Aerodigestive Tract;Affect;Anatomy;Anti-viral Response;antiviral immunity;Area;Bioinformatics;Body System;Cells;Cessation of life;Clinical;cohort;Complement;Coughing;COVID-19;COVID-19 patient;cytokine;Defect;Defense Mechanisms;density;Development;Disease;Enrollment;Epithelial Cells;Epithelium;ethnic diversity;exhaustion;Exhibits;Fever;Flow Cytometry;Functional disorder;Future;Gene Expression;Generations;Genes;Gingiva;Goals;Host Defense;Human;IL17 gene;Immune;immune modulating agents;Immune response;Immunity;Immunization;Immunologics;Immunology;improved;in vivo;Individual;Infection;Inflammatory;Inflammatory Response;Injury;insight;Interdisciplinary Study;Interferons;Knowledge;Life;Link;Location;Metadata;mitochondrial dysfunction;Molecular Biology Techniques;Morbidity - disease rate;mortality;Mucous Membrane;Nasal Epithelium;Nasopharynx;neutrophil;next generation;Nose;novel therapeutics;Oral;oral biology;Oral cavity;oral cavity epithelium;Oral health;oral infection;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;patient population;patient subsets;Peptide Hydrolases;Peptides;Pharyngeal structure;Phenotype;Play;post SARS-CoV-2 infection;Preventive;Production;Prospective cohort;racial diversity;receptor;Regulation;Respiratory Signs and Symptoms;response;Role;Sampling;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Severe Acute Respiratory Syndrome;Severity of illness;Signal Transduction;single-cell RNA sequencing;Site;Sore Throat;Structure of gingival sulcus;Surface;System;Systemic disease;T cell receptor repertoire sequencing;T cell response;T memory cell;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Talents;Therapeutic;Tissues;TMPRSS2 gene;Type 2 Angiotensin II Receptor;Vaccinated;Vaccination;Vaccinee;Vaccines;Viral;Viral Genes;virology;Virus;Virus Diseases

PROJECT_TITLE: Initiation of immune responses to SARS COV2 in the oral cavity and upper airway

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Heart Disease;Nutrition;Obesity;Physical Activity;Prevention;Telehealth

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The limited success of our current approaches to improve long-term physical activity adherence in adults with overweight and obesity is a substantial barrier to effectively address the current obesity epidemic and prevention of cardiovascular disease. This mentored K01 application addresses the significant public health issue of obesity by expanding and pilot testing a theory-based physical activity program designed to enhance motivation in adults with overweight or obesity enrolled in a lifestyle weight management program. The proposed research is relevant to public health because it will improve long-term physical activity adherence, which will enhance health and reduce chronic disease risk, for the large number of U.S. adults who struggle with obesity and its adverse health consequences.

PI_NAMEs: OSTENDORF, DANIELLE M (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;arm;behavior change;Behavior Therapy;Body mass index;Body Weight;Body Weight decreased;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;career;Chronic Disease;Clinical Trials Design;Colorado;Data;design;Development;Devices;disorder risk;Dissemination and Implementation;dissemination science;Educational Curriculum;Effectiveness;effectiveness evaluation;Engineering;Enrollment;Ensure;Environment;Evaluation;Exercise;exercise intervention;experience;fitness;Focus Groups;follow-up;Foundations;Goals;Guidelines;Health;Health behavior;Human;implementation science;improved;Individual;Intervention;K-Series Research Career Programs;Knowledge;Life Style;live stream;Maintenance;Measures;Medical;mental imagery;Mentors;Mentorship;Methods;Mind;mortality;Motivation;multiphase optimization strategy;novel;Obesity;Obesity Epidemic;obesity prevention;Outcome;Overweight;Participant;Patients;person centered;Persons;Phase;Physical activity;pilot test;pilot trial;preference;Preparation;prevent;Prevention;primary outcome;program costs;programs;Public Health;Randomized;Recommendation;recruit;remote delivery;Research;Risk;Self Determination;success;Testing;theories;Theory of Change;therapy design;tool;Training;training opportunity;Training Support;trial design;Universities;user centered design;Videoconferencing;Weight;weight loss intervention;Weight maintenance regimen;Work

PROJECT_TITLE: Designing with dissemination in mind: Development and evaluation of a theory-based physical activity intervention using the Multiphase Optimization Strategy

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Cardiovascular;Emerging Infectious Diseases;Heart Disease;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative Influenza related morbidity and mortality continues to steadily increase each year, and the persons most at risk include those with cardiovascular disease. Vaccination reduces the incidence of cardiovascular events at the population level, but the degree of immunoprotection and cardioprotection achieved at the individual level is highly variable. We will investigate the extent to which upstream immune-inflammatory mediators account for individual differences in response to therapy and propensity for developing cardiovascular events.

PI_NAMEs: CHENG, SUSAN  (contact)

PROGRAM_OFFICER_NAME: PUGGAL, MONA A

PROJECT_TERMS: Acute;adaptive immunity;Address;Adult;adverse event risk;adverse outcome;Affect;Ancillary Study;Anti-Inflammatory Agents;Antibody Response;Antibody titer measurement;Antigens;Biological Assay;Biological Response Modifiers;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Models;cardiovascular risk factor;Cardiovascular system;Cell Physiology;Cells;Cessation of life;Chronic;Circulation;Clinical;clinically relevant;co-infection;cohort;Communities;Complex;Congestive Heart Failure;cost effective;Cytometry;Data;Dose;Eicosanoid Modulation;Eicosanoids;Event;exhaustion;Exposure to;Family;Framingham Heart Study;Funding;hazard;Heart failure;Heterogeneity;high risk;Hospitalization;Human;human data;Humoral Immunities;Immune;Immune response;Immune system;improved;In Vitro;in vivo;Incidence;Individual;Individual Differences;Infection;Inflammation Mediators;Inflammatory;Inflammatory Response;Influenza;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;influenza infection;Influenza vaccination;influenza virus strain;influenza virus vaccine;Infrastructure;Laboratories;Lipids;Mass Spectrum Analysis;Mediating;Mediator;Methods;Molecular;Morbidity - disease rate;mortality;mouse model;National Heart, Lung, and Blood Institute;Natural Immunity;novel coronavirus;Participant;participant enrollment;Pathway interactions;Patients;Pattern;Persons;Phenotype;Pilot Projects;Plasma;Polyunsaturated Fatty Acids;Population;Populations at Risk;pre-clinical;Predisposition;Preventive therapy;Randomized, Controlled Trials;Research Design;Resistance;response;Risk;Role;Sampling;Seasons;Specimen;stem;Stimulus;Stress;Testing;Time;treatment response;trial design;Vaccination;vaccination outcome;vaccine immunogenicity;Vaccines;Validation;Variant;Viral;Virus Diseases;Vital Statistics

PROJECT_TITLE: Vaccine Induced Immune-Inflammatory Response and Cardiovascular Risk

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Cancer;Chronic Pain;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pain Research;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative The outcomes of minority patients with advanced cancer remains poor despite many attempts at improving equity. This project will evaluate the role of implicit bias in contributing to some of these disparate outcomes including patient-centered communication, pain, psychological distress, satisfaction with communication and decisional conflict. We will audio record communication encounters of 60 oncologists and their 360 patients with advanced cancer in New York City and in Durham, NC to evaluate differences in these critically important outcomes.

PI_NAMEs: SMITH, CARDINALE B (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Affect;Belief;Black Populations;Black race;cancer care;cancer health disparity;Cancer Patient;cancer therapy;Caring;chemotherapy;clinical encounter;Communication;Conflict (Psychology);cultural competence;Data;Data Set;Diagnosis;Discrimination;Disparity;Educational Status;Equity;ethnic difference;ethnic disparity;Ethnic Origin;Ethnic Population;Evaluation;follow-up;Foundations;Goals;Guidelines;health care disparity;Health system;Hispanic;Hispanic Populations;Image;Implicit Association Test;implicit bias;improved;improved outcome;Incidence;Individual;Inequity;Inferior;Institute of Medicine (U.S.);Institutional Racism;instrument;Intervention;Interview;Judgment;Knowledge;Link;Malignant Neoplasms;Measures;Mediating;Minority;minority patient;New York City;Oncologist;Oncology;Outcome;outcome disparities;Pain;Pain management;Pain Measurement;pain relief;Patient Care;patient oriented;Patient-Focused Outcomes;Patients;people of color;Persons;Physicians;Play;Population;preference;Process;Prognosis;programs;provider factors;psychological distress;Quality of life;Race;racial difference;racial disparity;racial diversity;racial population;Recommendation;recruit;Reporting;Research;Role;satisfaction;Solid;Surveys;System;Time;Translating;Unconscious State;Universities;Visit

PROJECT_TITLE: The Role of Implicit Bias on Outcomes of Patients with Advanced Solid Cancers

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: Electrical stimulation of the spinal cord aims to take advantage of spared neural circuitry to promote functional recovery following spinal cord injury (SCI). This can be done non-invasively through transcutaneous spinal cord stimulation (TSCS). Small, proof-of-principle studies have shown that TSCS can be targeted to restore blood pressure to more normal and stable levels in hypotensive individuals with chronic, motor-complete SCI. Improved blood pressure control with TSCS is attributed to the restoration of intrinsic autonomic cardiovascular regulation. If true, improvement in other physiological systems that are regulated by the autonomic nervous system should be evident with targeted TSCS. We will identify TSCS parameters that normalize blood pressure in hypotensive individuals with chronic SCI and determine if these TSCS settings improve exercise endurance, recovery from exercise, regulation of core body temperature, and perception of thermal comfort.

PI_NAMEs: WECHT, JILL M. (contact)

PROJECT_TERMS: adverse outcome;Anus;arm;Autonomic Dysreflexia;Autonomic nervous system;Bladder;Bladder Control;Blood Flow Velocity;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure reduction;blood pressure regulation;Body Temperature;Cardiac;Cardiovascular system;Cerebrovascular Circulation;Cervical spinal cord injury;Chronic;climate change;Clinical;cohort;digital;Drowsiness;Electric Stimulation;endurance exercise;Environment;Equilibrium;Ergometry;Esthesia;Exercise;Exposure to;Fatigue;Frequencies;Functional disorder;Health;Heart Rate;Homeostasis;Hypotension;Hypotensives;Impairment;improved;Individual;Injury;Intervention;Intestines;Lead;Lesion;Maps;millisecond;Morbidity - disease rate;mortality;Motor;motor recovery;Nervous System control;Nervous System Physiology;neural;neural circuit;Neuronal Plasticity;Neurostimulation procedures of spinal cord tissue;Orthostatic Hypotension;Participant;Perception;Performance;Personal Satisfaction;Persons;Phase;Physiologic pulse;Physiologic Thermoregulation;Physiological;Population;Positioning Attribute;prevent;Quality of life;Recovery;Recovery of Function;Rectum;Regulation;Reporting;response;restoration;Safety;Sensory;Site;social engagement;Spinal cord injury;Sports;Supination;System;Temperature;Testing;Time;trial comparing;Variant;Veterans;Walking;Width

PROJECT_TITLE: Autonomic Effects of Transcutaneous Spinal Cord Stimulation in Veterans with SCI

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nanotechnology;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: African American women with triple negative breast cancer have much worse clinical outcome, in terms of early relapse, aggressive metastasis and 5-year survival rate of 14% compared to 36% for other races. We have discovered race-specific single nucleotide polymorphism in TRIM37 that strongly correlates with high TRIM37 expression in African American women, and aggressive metastatic phenotype. This project will demonstrate that TRIM37 is a genetic variant associated with high risk of metastatic TNBC in African American women and generate proof-of-concept data to treat metastatic TNBC using TRIM37-specific antisense oligonucleotide and investigational clinical anti-FOLR1 antibody-guided nanoparticles.

PI_NAMEs: BHATNAGAR, SANCHITA  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Address;Affect;African American;African American Women;Alleles;Anoikis;Antibodies;Antisense Oligonucleotides;Artificial nanoparticles;Biological;Brain;Breast;Breast Cancer Cell;Breast Cancer cell line;breast cancer metastasis;Breast Cancer Patient;Breast Cancer Risk Factor;Breast Cancer Treatment;Breast Epithelial Cells;cancer cell;cancer health disparity;cancer predisposition;cancer subtypes;Caucasians;causal variant;Cell Line;Circulation;Clinical;clinically relevant;comorbidity;CRISPR screen;Data;Data Set;Death Rate;Dependence;Development;Disease;Disparity;disparity reduction;Distant;efficacy evaluation;Engineering;Epigenetic Process;ethnic diversity;Ethnic Origin;experience;folate-binding protein;FOLR1 gene;Functional dependence;Gene Expression Profile;Genes;Genetic;Genetic Determinism;Genetic Polymorphism;Genetic Risk;Genetic Transcription;genetic variant;Genome;Genotype;Goals;Growth;Head Start Program;health care availability;health care disparity;high risk;In Vitro;in vivo;in vivo Model;Incidence;Infiltration;innovation;Legal patent;Link;Liver;Malignant Breast Neoplasm;Mammary Gland Parenchyma;Metastatic breast cancer;Metastatic Neoplasm to the Lung;Molecular Target;mouse model;nanoparticle;Neoplasm Metastasis;novel;Oncogenic;Oncoproteins;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patients;Phase I Clinical Trials;Phenotype;Predisposition;Prognosis;Prognostic Marker;programs;prospective;Proteins;Quantitative Trait Loci;Race;racial disparity;Racial Segregation;rational design;Relapse;Resistance;Risk;Single Nucleotide Polymorphism;Site;survival outcome;Survival Rate;Susceptibility Gene;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Intervention;Tissues;transcriptomics;treatment disparity;TRIM Motif;triple-negative invasive breast carcinoma;tumor;Tumor Burden;tumor growth;Tumor Tissue;Variant

PROJECT_TITLE: TRIM37 is a genetic determinant of racial disparity in metastatic TNBC patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-B(55)R]


NIH_SPENDING_CATS: Cancer;Genetics;Skin Cancer

ORG_CITY: LA JOLLA

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Dysregulation in gene expression programs can lead to cancer including squamous cell carcinomas which is the 2nd most diagnosed cancer in the U.S. This proposal seeks to understand the underlying molecular mechanisms that govern the progression of normal human skin to neoplasia. The efforts of this proposal will define the role of the mRNA export pathway in tumor initiation, which may yield insights into the development of therapies for epidermal disorders.

PI_NAMEs: SEN, GEORGE L (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: 3' Untranslated Regions;3-Dimensional;Adaptor Signaling Protein;Address;Apoptosis;Applications Grants;Automobile Driving;Basement membrane;Binding;Binding Proteins;cancer diagnosis;Cell Line;cell motility;Cell Survival;Cells;clinically relevant;Code;Complex;crosslinking and immunoprecipitation sequencing;Cytoplasm;Data;Dermal;design;Disease;Epidermis;experimental study;Family;Gene Expression;Generations;Genes;Genetic Transcription;Growth;Human;human model;Immune;in vivo;insight;knock-down;Lead;loss of function;Malignant Neoplasms;MAP Kinase Gene;Mediating;Melanoma Cell;member;Messenger RNA;Mitosis;Modeling;Molecular;Motility;mRNA Export;Mus;Mutation;Natural regeneration;Neoplasms;neoplastic;Neoplastic skin;new technology;Normal tissue morphology;Nuclear Pore Complex;Oncogenic;Output;overexpression;Pathway interactions;pluripotency;Process;programs;protein complex;Proteins;Regulation;Reporting;Research Design;RNA;Role;Signal Transduction;Skin;Specificity;Squamous cell carcinoma;stem;therapeutic target;therapy development;Transcript;transcription factor;Translating;tumor;tumor initiation;tumor progression;Tumor Promotion;Tumor stage;tumorigenesis;VEGFC gene

PROJECT_TITLE: Regulation of Human Tumorigensis by Cancer Specific NXF1 Adaptor Proteins

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Cancer;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Radiation-resistant prostate cancer (RR-PCa) is highly unpredictable which frequently results in cancer recurrence in many patients. This project aims to 1) establish the underlying mechanism(s) of mitochondrial biogenesis that contribute to RR-PCa cell survival and metabolism and 2) determine if targeting inherent mitochondria and radiation-acquired mitochondria, can overcome RR-PCa. The successful completion of this project will establish a new and significant therapeutic platform for making radiation therapy more effective.

PI_NAMEs: CHAISWING, LUKSANA  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Animal Model;Antibiotics;Azithromycin;Biochemical;Biogenesis;bioluminescence imaging;cancer cell;cancer heterogeneity;cancer recurrence;cancer subtypes;cancer survival;catalase;Cell Death;Cell Survival;Cells;Cellular Metabolic Process;Cessation of life;Clinical Treatment;Computer software;Coupled;Cytoplasm;Data;Dose;Electron Transport;Enzymes;Event;Exhibits;External Beam Radiation Therapy;Failure;FDA approved;fractionated radiation;Growth;high risk;Homeostasis;Hydrogen Peroxide;Image;Impairment;improved;In Vitro;in vivo;inhibitor;insight;knock-down;Macrolides;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Mitochondrial Proteins;Molecular;mortality;mtTF1 transcription factor;Mus;Normal Cell;novel;novel therapeutics;overexpression;Oxidation-Reduction;Oxidative Phosphorylation;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phase;prevent;Property;Prostate;prostate cancer cell;prostate cancer model;Protein Array;Proteins;prototype;Radiation;radiation delivery;radiation resistance;Radiation therapy;Radiation Tolerance;radioresistant;Reactive Oxygen Species;Recurrence;Regulation;Research Design;Resistance;Resistance development;Resolution;response;Site;stable isotope;success;superresolution microscopy;tempol;Testing;Therapeutic;Time;Translating;Translational Repression;Translations;Treatment Efficacy;tumor;tumor growth;tumor heterogeneity;Visualization;Xenograft Model

PROJECT_TITLE: Targeting Mitochondrial Redox Capacity to Overcome Cancer Subtype that Regrowth After Radiation

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: ANN ARBOR

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Narrative (Overall) The Michigan Lifestage Environmental Exposures and Disease (M-LEEaD) Environmental Health Sciences Core Center provides infrastructural support for research, research translation, career development and training, and community engagement to address critical knowledge gaps of lifestage vulnerability to environmental exposures.

PI_NAMEs: DOLINOY, DANA  (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Acceleration;Address;Adolescent;Adult;Advocacy;Affect;Age;Aging;anti-racism;Articulation;Asthma;Award;career;career development;Child;Chronic Disease;climate change;climate impact;climate-related health;Clinical;Collaborations;Communities;community engagement;Complex;Conceptions;Core Facility;Coupled;Data Science;data to knowledge;Development;Discipline;Disease;Education;Environment;Environmental Exposure;Environmental Health;Environmental Impact;Epidemiology;Epigenetic Process;Equity;equity, diversity, and inclusion;Etiology;experience;Exposure to;Fostering;Foundations;Future;Genetic Processes;Goals;Grant;Health;health determinants;health disparity;Health Promotion;health science research;Health Sciences;Human Biology;human disease;improved;Individual;Infant;innovation;Institution;Investigation;Knowledge;Leadership;Learning;Life;life span;member;Metabolic syndrome;Michigan;middle age;Mission;multiple omics;National Institute of Environmental Health Sciences;Neurodegenerative Disorders;next generation;novel;Outcome;Patients;Pilot Projects;Policies;population health;practical application;Predisposition;prenatal;present value;prevent;Program Development;programs;public health intervention;reproductive;Research;Research Activity;Research Personnel;Research Support;Resources;Role;Science;Scientist;Strategic Planning;Structure;Superfund;Toxicology;Training;Training Support;Translating;translational impact;Translational Research;Translations;Universities

PROJECT_TITLE: Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(P)]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PROJECT_TERMS: Acceleration;Address;Administrative Efficiency;Advisory Committees;Advocacy;Applications Grants;Basic Science;Budgets;career;career development;climate change;climate-related health;Clinical;Collaborations;Communication;Communities;community engagement;community research;Consultations;Core Facility;COVID-19;Data;Dedications;Disclosure;Disease;efficacy evaluation;Elements;Ensure;Environmental Exposure;Environmental Hazards;Environmental Health;Environmental Impact;Evaluation;Event;Faculty;Feedback;Focus Groups;Fostering;Funding Opportunities;Goals;Grant;Health;health disparity;high standard;human disease;improved;Individual;innovation;International Aspects;Internet;Knowledge;Leadership;Learning;Life;meetings;member;Mentors;Michigan;Mission;National Institute of Environmental Health Sciences;Outcome;Patients;Performance;Pilot Projects;Policy Maker;population health;practical application;Process;Program Development;Program Evaluation;programs;Public Health;public health intervention;Publications;Recommendation;Records;Reporting;Research;Research Activity;research and development;Research Personnel;response;Science;Scientist;Services;skills;Structure;symposium;Technology;theories;tool;Toxicology;Training;Translational Research;translational research program;Translations;Vision;Visit;Work

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: Project Narrative High-grade gliomas of the cerebral cortex are intractable brain tumors with a 5-year survival of less than 20%. Recurrent Gly34Arg/Val substitutions in Histone H3.3 (H3.3 G34R/V) occur in more than 15% of cerebral cortex high-grade gliomas found in adolescents and young adults. This proposal aims to determine the impact of H3.3 G34R/V mutations on transcriptional regulatory patterns contributing to tumorigenesis and identify critical transcription factor dependencies by leveraging a novel collection of primary tumors, patient-derived orthotopic xenografts, and a range of patient-derived cell lines modeling wild-type, H3.3 G34R/V mutant, and CRISPR- corrected H3.3 G34R/V backgrounds.

PI_NAMEs: ROACH, JORDAN TRENT (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;Adolescent and Young Adult;Age;Anatomy;Apoptotic;ATAC-seq;Biological Assay;Biology;Brain;Brain Neoplasms;cancer cell;Cancer Etiology;Cell Line;Cell Proliferation;Cell Survival;Cells;Central Nervous System;Cerebral cortex;Chemotherapy and/or radiation;Child;Childhood;Childhood Brain Neoplasm;Childhood Glioma;ChIP-seq;Chromatin;clinical training;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;Complex;CRISPR correction;CRISPR/Cas technology;curative treatments;Data;Dependence;Development;Developmental Gene;Disease;DNA Binding;DNA Binding Domain;DNA Methylation;Enhancers;Epigenetic Process;Essential Genes;Etiology;Excision;Exclusion;Exhibits;experience;Frequencies;Functional dependence;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;genome-wide;genomic platform;Genomics;Glioma;glioma cell line;Histone H3;Histone H3.3;human stem cells;improved;In Situ Nick-End Labeling;Individual;Interneurons;Investigation;knock-down;Label;Laboratories;loss of function;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Mediating;member;Mentors;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;mutant;Mutate;Mutation;neoplastic cell;neuro-oncology;Neurons;neurosurgery;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Operative Surgical Procedures;Patients;Pattern;Physiological;Primary Neoplasm;programs;Quantitative Reverse Transcriptase PCR;Radiation therapy;Recurrence;Research;RNA Interference;Role;Small Interfering RNA;spatiotemporal;Specific qualifier value;standard of care;stem cell model;stem cells;Techniques;Therapeutic;transcription factor;transcriptome sequencing;tumor;Tumor Stem Cells;tumorigenesis;Western Blotting;Xenograft procedure

PROJECT_TITLE: Identifying a transcriptional core regulatory circuitry and other critical transcription factor dependencies in H3.3 G34R/V high-grade glioma


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSURGERY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative  Perturbing early development events can have profound consequences for the structural and functional integrity of the brain. In the olfactory system innovative strategies developed in the past several decades provided significant new insights into odor processing in the olfactory epithelium and olfactory bulb. In the current proposal we seek to develop a similar understanding of odor processing at the 3rd tier of the olfactory system, piriform cortex, by implementing novel molecular/genetic tools to understand how choreographed developmental events establish the foundations of cortical odor coding.

PI_NAMEs: GREER, CHARLES A (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Address;Adult;Afferent Neurons;Anterior;anterior commissure;Architecture;Attention;Axon;Brain;Cells;Cilia;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complex;connectome;Contralateral;course development;Data;Development;Didelphidae;Electroporation;Epithelium;Event;Foundations;FOXP2 gene;Genetic;Goals;hippocampal pyramidal neuron;in utero;innovation;insight;Interneurons;Ipsilateral;Knock-out;Knowledge;Lateral;Learning;Lens development;Ligand Binding;Maps;Methods;migration;Molecular;Mus;Neocortex;neocortical;nerve supply;neural circuit;neuroblast;neurogenesis;Neuroglia;Neurons;novel;Odorant Receptors;Odors;olfactory bulb;Olfactory Epithelium;Olfactory Pathways;olfactory sensory neurons;piriform cortex;Play;Property;Radial;Rattus;receptor;Recurrence;Resolution;Role;segregation;Seminal;sensory system;Shapes;Smell Perception;SOX5 gene;spatiotemporal;Specificity;Structure;Study models;Surface;Synapses;Testing;timeline;tool;transcription factor;Work

PROJECT_TITLE: Piriform cortex: sequential developmental events

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Clinical Research;Machine Learning and Artificial Intelligence;Prevention;Social Determinants of Health

PI_NAMEs: O'NEILL, MARIE SYLVIA (contact)

PROJECT_TERMS: Acceleration;Address;analytical method;Animals;biobank;Biometry;Clinical;Clinical Research;Communities;community engaged research;community engagement;Community Practice;Consultations;Data;Data Analyses;data management;data resource;Data Security;Development;Disease;Education;Educational workshop;Ensure;Environmental Exposure;Environmental Health;Environmental Impact;Environmental Risk Factor;Fostering;gene environment interaction;Goals;health practice;Health Sciences;Human;human disease;improved;interdisciplinary collaboration;Joints;Laboratories;learning strategy;Life;Life course epidemiology;Life Cycle Stages;Link;Location;Machine Learning;member;Methodology;Michigan;Mission;Monitor;multidimensional data;National Institute of Environmental Health Sciences;novel;Online Systems;Partnership Practice;Persons;Play;Policies;pollutant;Poly-fluoroalkyl substances;Population Sciences;Professional Practice;Protocols documentation;public health intervention;Public Health Practice;Reporting;repository;Research;Research Design;Research Personnel;research vision;Resources;Safety;sample collection;Sampling;Scholarship;Science;Scientist;Series;Services;sound;Specimen;Statistical Data Interpretation;statistical learning;Statistical Methods;statistics;Structure;Students;success;symposium;Teacher Professional Development;Toxicology;Training;Translational Research;Translations;Update;web site;webinar;Work

PROJECT_TITLE: Integrated Health Sciences Core


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Atherosclerosis;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE South Asians (individuals from India, Pakistan and Bangladesh) have significantly more cardiovascular disease than other U.S. race/ethnic groups. However, Pakistanis and Bangladeshis may have even higher disease burden compared to Asian Indians. We propose to add Pakistanis and Bangladeshis to our ongoing study of South Asians that includes mostly Asian Indians to understand the complex drivers of cardiovascular health disparities in these three diverse and growing immigrant groups.

PI_NAMEs: ISLAM, NADIA S;KANAYA, ALKA M. (contact);KANDULA, NAMRATHA R

PROGRAM_OFFICER_NAME: JOSEPH, SUSAN KALAPURA

PROJECT_TERMS: Acculturation;Adopted;Adult;Affect;Age;Area;Asian Indian;Asian population;Atherosclerosis;Bangladesh;Bangladeshi;biopsychosocial;burden of illness;Canada;Cardiovascular Diseases;cardiovascular health;Characteristics;Chicago;Clinical;cohesion;cohort;Cohort Studies;Communities;Complex;coping;Country;Cultural Backgrounds;Data;Data Aggregation;Development;Diabetes Mellitus;Diet;Discrimination;Disparity;Dyslipidemias;Enrollment;ethnic diversity;Ethnic Population;experience;Genetic Variation;Goals;Health Disparities Research;health disparity;Hypertension;Immigrant;Immigrant community;Immigration;India;Individual;Interview;Knowledge;Longitudinal cohort study;Longitudinal Studies;low socioeconomic status;Measures;Mediating;Mediator;Methods;Muslim population group;Neighborhoods;New York;New York City;Obesity;Pakistan;Participant;Pattern;Physical activity;Population;Poverty;Prevalence;Prevention strategy;Process;protective factors;Public Health;racial population;Recording of previous events;recruit;Religiosity;Reporting;resilience;Resources;Risk;Risk Factors;Role;Sampling;San Francisco;Science;Smoking;social capital;social culture;Social Network;Social support;Socioeconomic Status;South Asian;stressor;Structure;Subgroup;Surveys;Testing;Tobacco use;United Kingdom;United States

PROJECT_TITLE: Understanding health disparities in Pakistani, Bangladeshi and Asian Indian immigrants: the role of socio-cultural context,  acculturation and resilience resources

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunization;Radiation Oncology

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Radioiodine is commonly used to treat patients with thyroid cancer, but it is often ineffective when the disease progresses or is more advanced. Blocking the abnormal proteins that cause the most common forms of the disease with specific drugs can restore the ability of thyroid cancer cells to trap radioiodine. This study tests new approaches to prolong the time that the radioiodine remains within the cancer cell so that a greater radiation dose can be delivered, and develops novel therapeutic antibodies to increase the immune response against these thyroid cancers.

PI_NAMEs: FAGIN, JAMES A (contact);HO, ALAN L.

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: Address;Adjuvant;Age;Attenuated;Biological;Biological Markers;Bispecific Antibodies;BRAF gene;cancer cell;Case/Control Studies;cell killing;Clinical Trials;Combined Modality Therapy;Differentiated Gene;Differentiation Therapy;dimer;Disease;Disease remission;Drug Targeting;ERBB2 gene;ERBB3 gene;exome sequencing;Feedback;Gene Expression;Genes;Genomics;Goals;Immune response;Impairment;improved;inhibitor;insight;Interruption;Iodides;Iodine;kinase inhibitor;Kinetics;Malignant neoplasm of thyroid;Malignant Neoplasms;MAP Kinase Gene;MEKs;Metastatic/Recurrent;Mitogen-Activated Protein Kinase Inhibitor;Molecular;mouse model;Mus;mutant;Mutation;Neoplasm Metastasis;neoplastic cell;novel strategies;novel therapeutics;Oncoproteins;oxidation;Pathway interactions;patient population;Patients;Pharmaceutical Preparations;Phase I Clinical Trials;PIK3CG gene;pilot trial;Property;Protein Isoforms;Proteins;Radiation Dose Unit;Radioactive Iodine;radioiodine therapy;RAS driven cancer;recruit;Refractory;Research Design;Resistance;responders and non-responders;response;restoration;Schedule;Series;Signal Transduction;small molecule;T-Lymphocyte;Testing;Therapeutic antibodies;Thyroglobulin;Thyroid Gland;Thyroidectomy;Time;Toxic effect;trait;transcriptome;transcriptomics;tumor;tumor heterogeneity;tumor microenvironment;Tyrosine;uptake

PROJECT_TITLE: Improving efficacy of radioiodine treatment of thyroid cancer

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


NIH_SPENDING_CATS: Bioengineering;Social Determinants of Health

PI_NAMEs: BATTERMAN, STUART A (contact)

PROJECT_TERMS: Acceleration;Address;Air;Air Pollution;analytical method;Archives;Area;Biological;Biological Markers;Biological Monitoring;Blood;Center for Translational Science Activities;Central Nervous System;Chemicals;Clinical;Collaborations;community center;community engagement;community organizations;Complement;Consultations;cost;cost effective;Data;Data Analyses;data modeling;design;Detection;detection limit;Development;Disease;Dryness;Ensure;Environmental Exposure;Environmental Health;Environmental Impact;Exposure to;Fees;Food;Funding;Genome;Goals;Hair;health science research;Health Sciences;improved;Individual;individual variation;innovation;Knowledge;Laboratories;Life;Link;Maps;Measurement;Measures;member;method development;Methods;Michigan;Microbiology;Mission;Modeling;Molecular;Monitor;National Institute of Environmental Health Sciences;novel;outreach;Performance;Pilot Projects;Plasma;Policies;Policy Maker;pollutant;practical application;Productivity;Public Health;public health intervention;quality assurance;Referral and Consultation;Research;Research Personnel;Research Project Grants;Research Proposals;Research Support;Resolution;Route;Sampling;Scientist;Services;Soil;sound;Source;Specimen;Spottings;Sputum;Statistical Data Interpretation;System;Systems Analysis;Time;Translating;Translational Research;Translations;trend analysis;Universities;uptake;Urine;Validation;Vision;Water;Work;Youth

PROJECT_TITLE: Exposure Assessment Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Mental Health;Mental Illness;Pediatric;Prevention;Sleep Research

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Relevance to Public Health Sleep disruption during the transition to college can give rise to many health problems that prevent students from successfully navigating a path to a postsecondary degree. Fortunately, sleep is a modifiable behavior. Testing the effectiveness of interventions to improve the sleep of a broad population of students could reveal effective strategies for colleges to pursue in order to improve the sleep quality of their students.

PI_NAMEs: BOWER, JULIENNE E;FULIGNI, ANDREW J (contact)

PROGRAM_OFFICER_NAME: KING, TRACY

PROJECT_TERMS: actigraphy;Acute;Address;Adult;Affect;Age Years;aging population;Anxiety;anxiety symptoms;arm;associated symptom;Attention;Awareness;Biological;Chronic;Clinical;clinically significant;cognitive function;Cognitive Therapy;college;Crowding;depressive symptoms;Development;Distress;Education;Effectiveness;Effectiveness of Interventions;effectiveness testing;efficacy testing;efficacy validation;emotional functioning;Ethnic Origin;Exhibits;Feeling;Genomics;Health;Health Campaign;improved;improvement on sleep;Individual;Inflammation;Inflammatory;inflammatory marker;Intervention;intervention effect;Loneliness;Measures;Mental Depression;Mental Health;mindfulness;mindfulness intervention;modifiable behavior;Motivation;Outcome;Patient Self-Report;Personal Satisfaction;physical conditioning;Physical Function;poor sleep;Population;Population Heterogeneity;Positioning Attribute;post intervention;prevent;primary outcome;Process;programs;psychosocial;psychosocial adjustment;Public Health;Public Health Education;Publishing;Randomized, Controlled Trials;Reporting;Research;residence;response;secondary outcome;sex;Sleep;sleep difficulty;Sleep disturbances;sleep health;sleep quality;Sleeplessness;social integration;Standardization;Students;success;Symptom Burden;Techniques;Testing;Time;Universities;university student;Variant;Youth

PROJECT_TITLE: Improving Sleep Quality During the Transition to College

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Social Determinants of Health

PI_NAMEs: SARTOR, MAUREEN AGNES (contact)

PROJECT_TERMS: Acceleration;Address;Applications Grants;Applied Research;Area;Basic Science;Bioinformatics;bioinformatics tool;Biological;Biological Assay;Biological Markers;biomarker signature;Cells;Classification;Clinical;Collaborations;Communities;community engagement;cost;Data;data management;Data Science;Data Science Core;Data Scientist;data sharing;data visualization;Databases;Dedications;design;Development;Disease;Environmental Exposure;Environmental Health;Environmental Impact;Epigenetic Process;epigenomics;Event;Evolution;experience;Faculty;Funding;Genetic;genome-wide;Genomics;Health;health science research;Human;Hybrids;innovation;interest;Laboratories;Life;Link;Machine Learning;Measures;member;metabolomics;Metagenomics;Methodology;Methods;Michigan;Mission;Molecular;multiple omics;National Institute of Environmental Health Sciences;new technology;novel;Pathway Analysis;Phenotype;Population;Precision Health;Preparation;Process;Proteomics;Protocols documentation;Public Health;Publications;Recommendation;Regulation;Research;Research Design;Research Personnel;Resources;sample collection;Sampling;Scientist;Services;statistical learning;Students;Techniques;Technology;technology platform;tool;Training;transcriptomics;Translational Research;Translations;Visualization;Writing

PROJECT_TITLE: Pan Omics and Data Science Core


ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: The overall goal of the proposed UCSF Environmental Research and Translation for Health Center (EaRTH Center) is to accelerate the pace of recognizing and preventing environmental exposures that affect reproduction and development, to improve health across the lifespan. We will offer focused resources to provide expertise and state-of-the-art technologies to create and support new research directions in environmental health at UCSF that are not currently possible. Our research will be tightly integrated with our community engagement, which will embed environmental health within the health care community. Our integrated Center will lead to new scientific understandings in environmental health, which will shift the fundamental understanding of the role of environment in disease, leading to solutions to preventing harmful exposures and improving health.

PI_NAMEs: WOODRUFF, TRACEY J. (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Analytical Chemistry;Bioinformatics;Biological;Biological Assay;Biomedical Research;California;career;Cell Nucleus;Cells;Chemical Exposure;Chemicals;Child;Chronic Disease;Clinical;Clinical Medicine;Clinical Research;Clinical Sciences;clinical training;Collaborations;Communication;Communities;community engagement;Community Outreach;Complex;Consultations;Core Facility;Data;data integration;Dentistry;Development;Diabetes Mellitus;Discipline;Discipline of Nursing;Disease;Education;Educational Curriculum;Environment;environmental chemical;Environmental Exposure;Environmental Health;Environmental Risk Factor;environmental stressor;Epidemiology;Exposure to;Family;Funding;Future;Goals;Health;health data;Health education;health literacy;Health Professional;Health Resources;Health Sciences;Healthcare;healthcare community;high throughput screening;Human;human tissue;improved;in vivo;Infrastructure;insight;Institution;interdisciplinary collaboration;International;Intervention;Investigation;Laboratories;Leadership;life span;Link;Location;Malignant Neoplasms;Measurement;Measures;Mediating;Medical;Medical Students;Medicine;member;men;Mentors;Mentorship;mobile computing;model organism;Modeling;National Institute of Environmental Health Sciences;Neurodevelopmental Disorder;next generation;Obesity;operation;outreach;Pathway interactions;Patients;Peer Review;Pharmacy facility;Pilot Projects;Positioning Attribute;Prevalence;prevent;Prevention;Production;programs;Proteomics;Publishing;Reproduction;reproductive;Reproductive Health;Research;Research Design;Research Personnel;Resources;Role;San Francisco;Schools;Science;Scientist;social stressor;Students;Technology;tool;Translating;Translational Research;Translations;Underserved Population;Universities;Vulnerable Populations;Women's Health;Work


PROJECT_TERMS: Acceleration;Address;Administrator;Advisory Committees;Affect;Area;Award;Basic Science;Biological Assay;Budgets;burden of chronic illness;California;career;career development;Childhood;Clinical Research;clinical training;Collaborations;Communication;Communities;community collaboration;community engagement;community organizations;community partners;Decision Making;Dedications;Development;Discipline;Discipline of Nursing;Education;Effectiveness;Ensure;Environment;Environmental Exposure;Environmental Health;epidemiology study;Evaluation;Faculty;faculty support;Fostering;Funding;Goals;Health;Health Sciences;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Investigation;Investments;Leadership;life span;Location;Medical;Medical Students;meetings;member;Mentors;Mentorship;Modification;Monitor;multidisciplinary;National Institute of Environmental Health Sciences;operation;organizational structure;Pilot Projects;Positioning Attribute;prevent;Prevention;Productivity;Professional Practice;Program Research Project Grants;programs;Publications;recruit;Reproduction;Research;Research Personnel;Research Project Grants;Resources;Role;San Francisco;Scholars Program;Science;Scientist;Services;Structure;success;Sum;Technology;Training;Translating;translational health science;Translational Research;Translations;Universities;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SCHULZ, AMY J (contact)

PROJECT_TERMS: Address;Adult;adverse birth outcomes;Advocacy;Advocate;Affect;Asthma;Awareness;Chemicals;Chronic Disease;climate change;Color;Communication;Communities;community engagement;community organizations;community research;Decision Making;Disease;Environment;Environmental Exposure;Environmental Health;Evaluation;Evaluation Methodology;experience;Fostering;Goals;Health;health inequalities;health literacy;Health Priorities;improved;Information Dissemination;Intervention;Knowledge;Life;Link;Low income;Malignant Neoplasms;member;Metabolic syndrome;Michigan;Modeling;next generation;Outcome;outreach;Physical environment;Policies;Policy Maker;population health;Process;Public Health;public health research;Research;Research Personnel;Research Priority;Risk;Role;Science;Scientist;Social Environment;Translating;Translational Research;Translations;Vision;Youth

PROJECT_TITLE: Community Engagement Core