NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Precision Medicine;Prevention

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative To help address the significant global demand for cancer genomics education, skills development and evidence-based patient care, this project proposes to continue a successful, multifaceted Intensive Course and global Clinical Cancer Genomics Community of Practice. The program leverages the expertise and resources of the academic center to prepare community-based clinicians with the knowledge and skills needed to integrate genomic advances into best practices in cancer risk assessment, personalized risk management and targeted cancer treatment. Fulfillment of the activities outlined in this proposal will further our efforts to grow the number of clinicians with practitioner-level proficiency in genetic cancer genetics across the U.S. and internationally.

PI_NAMEs: BLAZER, KATHLEEN R. (contact)

PROGRAM_OFFICER_NAME: ZAHIR, NASTARAN

PROJECT_TERMS: Accountability;Address;African American;Cancer Burden;Cancer Center;cancer genetics;cancer genomics;cancer risk;cancer therapy;Caring;cascade genetic testing;case-based;Clinical;clinical practice;Clinical Services;Communities;Community of Practice;Complex;Country;Dedications;Development;Distance Learning;Education;Educational Curriculum;Educational workshop;equity, diversity, and inclusion;Evaluation;evidence base;experience;Faculty;Feedback;Funding;Future;Genetic;genetic information;Genomics;Germ Lines;Goals;Health Professional;Hereditary Malignant Neoplasm;Hispanic;Hybrids;improved;Income;Infusion procedures;International;Knowledge;Learning;Letters;Medical Education;member;Mission;Modeling;multimodality;Participant;Patient Care;patient engagement;patient population;Patients;point of care;polygenic risk score;practice setting;precision medicine;Precision therapeutics;Professional Education;programs;Quality of Care;Resources;Risk Assessment;Risk Management;scale up;Self Direction;Self Efficacy;Services;skill acquisition;skills;socioeconomics;success;Surveys;Technology;Testing;Therapeutic;Training;tumor;Underrepresented Minority;Update;workforce needs

PROJECT_TITLE: Cancer Genetics Professional Education in a Global Community of Practice

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: During embryonic development, tissues split and merge to generate organs. The goal of this project is to dissect the mechanics of how cells within a tissue rearrange to split and how cells from different tissues interact to merge using the formation of a mechano-sensory organ called neuromast in zebrafish as a model. Our findings will improve understanding of organ malformation and inform the future development of therapeutic strategies against such birth defects.

PI_NAMEs: QIAN, WEIYI  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Actomyosin;Acute;Address;Adherens Junction;Adhesions;Affect;Back;Basement membrane;biophysical properties;Biophysics;career;Cell Adhesion Molecules;Cell-Cell Adhesion;Cells;Cleft Palate;Collaborations;Congenital Abnormality;Cues;Data;Defect;Deposition;Embryo;Embryonic Development;Event;experience;Experimental Models;experimental study;Extracellular Matrix;Future;Future Generations;gene function;Genetic;Goals;graduate student;Head;Health;high resolution imaging;Image;image processing;Impairment;improved;in vivo;insight;Integrins;Laboratory Research;lateral line;Learning;Link;malformation;Measures;mechanical properties;Mechanics;Meckel-Gruber syndrome;Mediating;Mentors;migration;Modeling;Molecular;Molecular Biology;Morphogenesis;neuromast;novel;Organ;Pattern;Penetration;Persistent Truncus Arteriosus;Phase;Positioning Attribute;post-doctoral training;Preparation;Primordium;Process;protein function;Proteins;Publications;quantitative imaging;Regulation;Research;Research Personnel;Resolution;Role;Rupture;Sensory Hair;Signal Transduction;skill acquisition;skills;Skin;Stress;student mentoring;Syndrome;Techniques;Testing;therapeutic development;Thinness;Tight Junctions;Time;Tissues;tool;Training;Water;Zebrafish

PROJECT_TITLE: Physical, cellular, and molecular control of tissue fission and fusion


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: SUS CLINICALS, INC.

ORG_STATE: OH

PHR: PROJECT NARRATIVE: Hepatocellular carcinoma (HCC), or primary liver cancer, results in considerable worldwide illness and fatality, highlighting the need for improved HCC treatment strategies. Advances in HCC treatments are highly dependent on the development of new systems to better understand cancer progression and treatment responses. The aim of this project is to validate a genetically defined pig HCC model capable of forming HCC tumors with different tumor biology for preclinical evaluation of locally delivered personalized therapeutics, with the overall goal of providing personalized tumor development and therapeutic testing services to device and pharmaceutical companies.

PI_NAMEs: SCHACHTSCHNEIDER, KYLE  (contact);SCHOOK, LAWRENCE B.

PROGRAM_OFFICER_NAME: TRIPURANI, SWAMY KRISHNA

PROJECT_TERMS: Aftercare;Animals;Area Under Curve;Arterial Embolization;Autologous;Biological;Biological Markers;Biopsy;Blood;Blood specimen;C-reactive protein;Cancer Etiology;Cancer Model;cancer therapy;cancer type;Canis familiaris;cell free DNA;Cells;Cessation of life;Clinical;clinical practice;clinically relevant;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Combined Modality Therapy;commercialization;comorbidity;Detection;Development;Devices;Diagnostic;Disease;Dose;driver mutation;drug metabolism;Evaluation;Family suidae;follow-up;Frequencies;Future;Genetic;Genetic Transcription;Genotype;Goals;Growth;Guidelines;hepatocellular carcinoma cell line;Histologic;Histology;Hour;Human;Image;improved;In complete remission;in vivo;inhibitor;inhibitor therapy;Injections;interest;intrahepatic;Kinetics;KRASG12D;Left;Letters;liquid biopsy;Liver;liver cancer model;Lobe;Malignant neoplasm of liver;Malignant Neoplasms;Marketing;Mass Spectrum Analysis;meetings;minimally invasive;Modeling;Monitor;Mutation;novel;Nucleosomes;Oncopig;personalized diagnostics;personalized therapeutic;Pharmacologic Substance;Phase;PIK3CG gene;Plasma;pre-clinical;precision medicine;preclinical evaluation;preclinical trial;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;response;SCID Mice;Site;Small Business Innovation Research Grant;System;targeted delivery;targeted treatment;Technology;Testing;testing services;Therapeutic;therapeutic development;therapeutic evaluation;therapeutic target;transcriptome sequencing;Translations;Treatment Efficacy;treatment response;treatment strategy;trial design;tumor;Tumor Biology;tumor growth;tumor progression;tumorigenic;Validation;Volition;Work;X-Ray Computed Tomography

PROJECT_TITLE: Validation of the Genetically Malleable Oncopig Hepatocellular carcinoma (HCC) Model for Targeted Therapeutic Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-T(10)B]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Nanotechnology;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: Treatment of brain cancer, and of its most common form, glioblastoma multiforme (GBM), with a 15-month average survival, still has limited treatment options. The emergence of efficacious nanodrugs able to cross blood-brain barrier (BBB) gives hope for new treatments of primary brain cancer. We will introduce new generation of nano immunopolymers that pass through BBB, modulate tumor microenviroment and activate brain tumor immune systems and block glioma specific molecular markers to achieve translationally-related GBM treatment efficacy.

PI_NAMEs: LJUBIMOV, ALEXANDER V (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Acids;Acute;Adaptive Immune System;Affect;Animals;anti-CTLA4;anti-CTLA4 antibodies;anti-PD-1;anti-PD1 antibodies;Antibodies;Biochemical;Bioinformatics;Biological Assay;Blood;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;Brain Neoplasms;c-myc Genes;cancer cell;Cancer Intervention;Cancer Patient;cancer therapy;Cell membrane;Cells;Clinical;Clinical Data;Clinical Trials;clinically relevant;Collaborations;CRISPR/Cas technology;Cytometry;Data;Development;DNA Sequence Alteration;dosage;Drug Delivery Systems;drug development;drug production;drug testing;effective therapy;endosome membrane;Endothelial Cells;Epidermal Growth Factor Receptor;Evaluation;Extracellular Matrix Proteins;Female;Gene Expression;Generations;Genes;Genetic Markers;Glioblastoma;Glioma;Growth;Human;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immune system;Immunologic Markers;Immunologic Surveillance;Immunotherapy;In Vitro;in vivo;Innate Immune System;Intravenous;Invaded;Laboratories;Laminin;Lead;Macaca fascicularis;Macrophage;male;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Maximum Tolerated Dose;molecular marker;Molecular Target;mouse model;Mus;nano;nanodrug;nanomedicine;nanopolymer;Nanotechnology;nanotechnology platform;Neoplasm Metastasis;neoplastic cell;No-Observed-Adverse-Effect Level;notch protein;novel;novel strategies;Organ;Oryctolagus cuniculus;overexpression;Pathologic;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Polymers;Population;precision drugs;Primary Brain Neoplasms;Primates;Production;Prognosis;programmed cell death protein 1;Proliferating;Proteins;Protocols documentation;Radiation;Radiation therapy;Recurrence;Relapse;Sampling;scale up;single-cell RNA sequencing;small molecule;standard of care;System;Technology;technology intervention;temozolomide;Testing;TFAP2A gene;Therapeutic antibodies;therapeutic RNA;Therapeutic Uses;Time;Toxic effect;Toxicology;transcriptome sequencing;Translational Research;translational study;Translations;Treatment Efficacy;tumor;tumor growth;tumor microenvironment;tumor-immune system interactions;Up-Regulation;Variant

PROJECT_TITLE: Targeting tumor microenvironment by nanoimmunodrugs for glioma treatment


ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE - OVERALL The purpose of this new, inter-institutional U54 application between San Diego State University (SDSU) and the University of California San Diego (UCSD) is to advance cancer health equity in underserved communities throughout the southern California border communities of San Diego and Imperial Counties. Under a new name – the Cancer Research and Education to Advance HealTh Equity (CREATE) Partnership – the overarching goals are to further increase SDSU’s cancer research capacities and expand SDSU’s and UCSD’s emphasis on cancer health disparities research. Additional goals include developing cancer research opportunities and pathways for undergraduate, graduate, and medical students as well as early-stage investigators (ESIs), which will lead to a future workforce that is more diverse and reflective of the catchment- area population.

PI_NAMEs: CRIPPS, RICHARD MATTHEW;MADANAT, HALA  (contact);MARTINEZ, MARIA ELENA;MURPHY, JAMES D

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Advanced Malignant Neoplasm;agricultural community;Alaska Native;American Indians;anti-cancer research;Asian;Automobile Driving;Behavior;Black Populations;Border Community;Breast;California;Cancer Burden;cancer education;cancer health disparity;Cancer health equity;career;career development;Caring;Catchment Area;Cause of Death;Colorectal;Communities;community academic partnership;community advisory board;community engaged research;community engagement;County;design;Dissemination and Implementation;Education;education research;Equity;ethnic diversity;Ethnic Population;Evaluation;Evidence based intervention;experience;Fostering;Funding;Future;gastrointestinal;Goals;graduate student;health assessment;Health Disparities Research;health equity;Hispanic Populations;improved;Incidence;insight;Institution;inter-institutional;Leadership;Linguistics;Liver;Lung;Malignant neoplasm of cervix uteri;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Students;Mentors;Minority;Names;Neighborhood Health Center;outreach;Pancreas;Pathway interactions;Pilot Projects;Population;population based;programs;Race;racial population;recruit;Research;Research Personnel;Research Project Grants;Resource Sharing;Risk Factors;Rural;screening;Screening for cancer;survivorship;Teacher Professional Development;undergraduate student;Underrepresented Students;underserved community;Universities

PROJECT_TITLE: 1/2 Cancer Research and Education to Advance HealTh Equity (CREATE) Partnership


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative: The synthetic opioid fentanyl presents the challenging clinical combination of ease-of-use (due to non- intravenous routes of administration), high euphoria, and severe withdrawal, but a mechanistic understanding of why some, but not all, individuals transition from use to abuse is not known. We will generate comprehensive machine-learning guided behavioral datasets comparing individual differences in oral and intravenous fentanyl seeking behavior in male and female mice, paired to spatially conserved single cell resolution gene expression patterns, whole brain circuit- and cell-type connectivity, and functional distributed brain-wide neural activity recordings. These data will provide a much-needed accessible oral fentanyl self- administration model for the neuroscience community, as well as the first fentanyl cellular-resolution brain atlas, and will deliver an accessible beachhead for the identification of novel circuit- and cell-type specific genes that can leveraged as the basis for future study.

PI_NAMEs: GOLDEN, SAM  (contact);GU, LIANGCAI ;NEUMAIER, JOHN F;STEINMETZ, NICHOLAS

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Address;Anatomy;Atlases;Bar Codes;Behavior;Behavioral;Biological Assay;Brain;brain cell;Brain Mapping;Brain region;brain tissue;brain volume;cell type;Cells;Classification;Clinical;combat;Communities;Coupling;Cues;Data;Data Set;differential expression;Drug Exposure;drug seeking behavior;Electrophysiology (science);Emotional;Euphoria;Female;Fentanyl;fentanyl abuse;fentanyl seeking;fentanyl self-administration;fentanyl use;FOS gene;functional adaptation;Future;gene conservation;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Goals;Heroin;Image;Immediate-Early Genes;Implant;in vivo;Individual;Individual Differences;individual variation;Infusion procedures;innovation;interest;Intravenous;learned behavior;Machine Learning;male;Maps;Methodology;Methods;Modeling;Molecular;Morphine;multimodal data;multimodality;Mus;neural;neural circuit;Neurons;Neurosciences;novel;open source;Opioid;opioid abuse;opioid mortality;opioid use;Oral;Oral Characters;Pharmaceutical Preparations;Phenotype;Population;Process;recruit;Relapse;relapse risk;Reporting;Resolution;response;Risk;Route;Self Administration;Slice;spatial integration;Specificity;synthetic opioid;Technology;technology platform;Time;transcriptome;transcriptomic profiling;transcriptomics;United States;Viral;Vulnerable Populations;Withdrawal

PROJECT_TITLE: Integrative single-cell spatial transcriptomic, anatomical, and functional profiling of brain-wide ensembles engaged by opioid relapse


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: MADANAT, HALA  (contact)

PROJECT_TERMS: Administrative Efficiency;Advisory Committees;anti-cancer research;Asian Americans;base;California;Cancer Center;cancer education;cancer health disparity;career;career development;Catchment Area;Collaborations;college;Communication;Communities;community advisory board;Community Outreach;Comprehensive Cancer Center;education research;Ensure;Environmental Health;Equity;evidence base;experience;Faculty;Feedback;Funding;Future;Glues;Goals;graduate student;Grant;Health Disparities Research;health equity;Hispanic-serving Institution;Infrastructure;Institution;Leadership;Malignant Neoplasms;Mediation;Medical Students;meetings;member;mid-career faculty;National Cancer Institute;Native Americans;operation;outreach;Pacific Island Americans;Pathway interactions;Peer Review;Persons;Population;Positioning Attribute;Principal Investigator;programs;Provider;Recording of previous events;recruit;Research;Research Personnel;Resource Sharing;Resources;Role;Schools;Scientist;Services;Structure;synergism;System;Teacher Professional Development;undergraduate student;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Orphan Drug;Pancreatic Cancer;Rare Diseases

PI_NAMEs: KATIRA, PARAG  (contact)

PROJECT_TERMS: 3-Dimensional;Acetylation;Actins;Adherence;Adhesions;Adhesiveness;Affect;African American;alpha Actin;American;anti-cancer research;Behavior;Binding;Biochemical;Biology;biophysical properties;Biophysics;cancer cell;cancer education;Cause of Death;Cell Adhesion;Cell Cycle Progression;Cell model;cell motility;Cell Nucleus;Cell Proliferation;Cells;Chemotherapy-Oncologic Procedure;Collaborations;Cytoplasm;Cytoskeleton;Cytosol;Data;depolymerization;Development;Disease;Disease Progression;effective therapy;Enhancers;Environment;Excision;experience;extracellular;Extracellular Matrix;F-Actin;Flavins;G Actin;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Goals;health equity;high risk population;Hispanic;Hospitals;Human;human disease;Impairment;improved;improved outcome;in vivo;Incidence;Insurance;Integrins;Invaded;Knowledge;Laboratories;Life;Link;Liver;Lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;mechanical properties;Mechanics;migration;Mixed Function Oxygenases;Morbidity - disease rate;mortality;myocardin;Myosin ATPase;Neoplasm Metastasis;new therapeutic target;Not Hispanic or Latino;novel therapeutic intervention;Nuclear;Nuclear Export;Nucleic Acid Regulatory Sequences;Outcome;Pancreas;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic stellate cell;Pathway interactions;patient population;Patients;Pattern;Phenotype;Play;Pre-Clinical Model;Primary Neoplasm;Property;Proteins;Reporting;Role;screening;Serum Response Factor;Signal Induction;Signal Transduction;Socioeconomic Status;Stromal Cells;Structure;Testing;therapeutic target;therapeutically effective;Transcription Coactivator;transcription factor;Transcriptional Regulation;tumor growth;tumor microenvironment

PROJECT_TITLE: Project 1: Defining Mechanisms of MICAL-dependent Pancreatic Cancer Cell Migration


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Infectious Diseases;Microbiome;Nutrition;Pediatric;Prevention

ORG_CITY: BURLINGTON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE Benjamin Lee, MD – Principal Investigator (PI) Childhood undernutrition is an enormous public health challenge, affecting over 200 million children and contributing to 45% of all deaths in children less than 5 years of age worldwide, primarily due to infectious diseases. This project will seek to determine whether undernutrition is associated with impaired development of adaptive immunity, and the potential role of aberrant microbiome development in mediating these outcomes. The insights gained may help inform improved strategies to prevent, identify, and treat the adverse manifestations of childhood undernutrition, which in the short term includes increased risk of morbidity and mortality from infectious diseases, and in the long term includes loss of achievement and neurocognitive potential and increased risk of obesity and chronic non-communicable diseases in adulthood.

PI_NAMEs: LEE, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: 10 year old;2 year old;5 year old;Achievement;Acute;adaptive immunity;Address;Adult;Affect;Age;Anthropometry;Bangladesh;Bangladeshi;Biological Markers;Birth;Cells;Cessation of life;Child;Child Development;Child Mortality;Childhood;Chronic;Cohort Studies;Communicable Diseases;Communities;Conceptions;Cross-Sectional Studies;Cryopreservation;Data;Defect;Development;Diarrhea;Disease;Evaluation;Failure;fecal microbiota;Feces;Goals;Growth;Growth and Development function;gut inflammation;gut microbiota;Health;high risk;Human;Immune;Immune system;immunodeficiency;immunological diversity;Immunologics;Impairment;improved;Infection;infection risk;Inflammation;Inflammatory;innovation;insight;Interdisciplinary Study;Intervention;intestinal maturation;Knowledge;Lead;Life;Longitudinal cohort;longitudinal dataset;Longitudinal Studies;Maintenance;Malnutrition;Measures;Mediating;Metabolic Pathway;Metabolism;metagenomic sequencing;Methodology;Methods;microbiome;microbiota;Minority;Modeling;Morbidity - disease rate;mortality;Nature;Neurocognitive;obesity risk;Organ;Outcome;pathogen exposure;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Pneumonia;Predisposition;prevent;Principal Investigator;Process;proteogenomics;Public Health;Research Design;Resource-limited setting;Risk;Role;Sampling;Shapes;Structure;systemic inflammatory response;T-Cell Development;T-cell diversity;T-cell receptor repertoire;T-Lymphocyte;Taxonomy;Testing;Underweight;Weight;Work

PROJECT_TITLE: Undernutrition, microbiota maturation, and adaptive immunity in Bangladeshi children

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

PI_NAMEs: PARADA, HUMBERTO  (contact)

PROJECT_TERMS: access disparities;Address;Adverse event;adverse outcome;anti-cancer research;beneficiary;California;cancer care;cancer education;cancer health disparity;Cancer Patient;cancer risk;care delivery;care outcomes;Caring;Catchment Area;Cohort Studies;Communication;Complement;County;COVID-19 pandemic;Data;Data Set;Databases;Development;Disparity;disparity reduction;Emergency department visit;Environment;Equity;ethnic minority;Ethnic Origin;experience;Future;health disparity;health equity;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;Hospitalization;Hospitals;Household;Improve Access;improved;Income;Individual;Inequality;Inequity;interest;Internet;Intervention;Knowledge;Language;Link;Logistic Regressions;Low income;Malignant Neoplasms;marginalized population;Medicare;Medicare claim;Medicare/Medicaid;Methods;Modeling;neoplasm registry;older adult;older patient;Oncology;Outcome;pandemic disease;Patient Care;patient population;Patient-Focused Outcomes;patient-level barriers;Patients;Perception;Persons;Policies;Policy Maker;Population;population based;Populations at Risk;Positioning Attribute;post-COVID-19;Provider;provider-level barriers;Quality of Care;Race;racial minority;Research;response;Risk;Safety;Secondary to;Socioeconomic Status;Surveys;Technology;Telecommunications;telehealth;Testing;Visit;Vulnerable Populations

PROJECT_TITLE: Project 2: The Intersection of Telehealth and Health Disparities in At-Risk Older Patients with Cancer


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA AGRICULTURAL AND MECHANICAL UNIV

ORG_STATE: FL

PHR: PROJECT NARRATIVE – OVERALL COMPONENT The long term goals of the CaRE2 center are to reduce cancer disparities in Black/African American and Hispanic/Latinx individuals, to train and increase the pool of 120 underrepresented Black/African American and Hispanic/Latinx scientists conducting health disparity research, to increase research capacity at an HBCU (FAMU), and to increase cancer disparity research at UF and USC-NCCC. The proposed two full projects and pilot project include investigators from the three institutions and will leverage on specimens collected across the partnership from Black/African American and Hispanic/Latinx, representing a wide range of subpopulations within these minority groups. Thus, our studies will reveal unprecedented findings about these two understudied minority populations, will be instrumental in transferring cutting edge and innovative technologies to FAMU, and will expand in a significant way the research focus at UF and USC-NCCC to address cancer health disparities in pancreas and lung cancers.

PI_NAMEs: ABLORDEPPEY, SETH Y;HUGHES-HALBERT, CHANITA A.;REAMS, ROMONIA RENEE (contact);STERN, MARIANA C;WILKIE, DIANA J

PROGRAM_OFFICER_NAME: BARFIELD-STEWARD, WHITNEY

PROJECT_TERMS: Address;Advocate;African;African American;American;anti-cancer research;Award;Back;Benchmarking;Bioinformatics;Biological;Biological Models;Biomedical Research;Black American;Black Populations;Black race;California;Cancer Center;Cancer Control;cancer health disparity;Cancer Model;Cancer Patient;cancer prevention;career development;Caribbean region;Caring;Catchment Area;Censuses;Central American;Communities;Community Outreach;community partnership;Complex;Comprehensive Cancer Center;Cultural Diversity;Development;Disparity;disparity reduction;Doctor of Philosophy;drug development;Education;education research;Educational Materials;Effectiveness;Evaluation;Extramural Activities;Florida;Fostering;Funding;genetic makeup;genome resource;Goals;Grant;Health;Health Disparities Research;health disparity populations;health equity;Heterogeneity;Hispanic;improved;improved outcome;Incidence;Individual;Infrastructure;innovation;innovative technologies;Institution;Latino;Latino Population;Latinx;Latinx population;Leadership;Location;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;meetings;member;Mentors;Methodology;Methods;Mexican Americans;Minority;minority communities;Minority Groups;minority patient;minority trainee;mortality;novel anticancer drug;Outcome;outreach;patient population;Pilot Projects;podcast;Population;Population Heterogeneity;Postbaccalaureate;Postdoctoral Fellow;Process;programs;Publications;Publishing;Reporting;repository;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Resource Sharing;Resources;Scientist;Series;social determinants;South American;Specimen;Students;success;Tissue Model;tool;Training;Training and Education;translational cancer research;Translational Research;Underrepresented Minority;Underrepresented Students;Underserved Population;understudied cancer;United States;Universities;University of Southern California Norris Cancer Center;US State;Use Effectiveness;Work

PROJECT_TITLE: 1/3 Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: REAMS, ROMONIA RENEE (contact)

PROJECT_TERMS: Address;African;African American;African Caribbean;anti-cancer research;Award;Benchmarking;Black race;California;Cancer Center;cancer health disparity;cancer prevention;Cancer Science;Career Mobility;Caring;Central American;Clinical Trials;Collaborations;Communication;Communities;Community Outreach;Comprehensive Cancer Center;Cuban American;Data;Development;Doctor of Philosophy;Education;Education and Outreach;education research;Educational Activities;Ensure;ethnic diversity;Evaluation;Event;Exhibits;Extramural Activities;Florida;Foundations;Funding;gender diverse;Goals;Grant;Growth;Health;Health Disparities Research;health equity;Hispanic;Human Resources;implementation strategy;improved;Individual;Infrastructure;Institution;interest;International;Intranet;Knowledge;Latina;Latino;Latinx population;Lead;Leadership;Link;Mexican;minority engagement;Minority Groups;minority scientist;Mission;Modeling;Monitor;Office of Administrative Management;Online Systems;Outcome;Prevention Research;Principal Investigator;Program Evaluation;programs;Publications;Puerto Rican;racial diversity;Research;Research Personnel;Research Project Grants;Resource Sharing;Scanning;Scientist;Series;sharing platform;South American;Strategic Planning;Structure;success;Supervision;symposium;Underrepresented Minority;United States National Institutes of Health;Universities;University of Southern California Norris Cancer Center;Vision;web site;webinar;Woman;Work


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Prevention;Rare Diseases

ORG_CITY: DETROIT

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Name of Applicant (Last, first, middle): Berkowitz, Bruce A. The proposed research is relevant to public health because retinitis pigmentosa is an untreatable cause of blindness. We address a long-standing critical barrier to the translation of experimental findings into the clinic: the absence of non-invasive imaging biomarkers of rod energy-landscape dysfunction for early diagnosis and for predicting treatment benefits. Our proposed studies will address this technology gap with a unique rod energy-landscape biomarker measured from a clinical-relevant imaging modality, optical coherence tomography, in order to enable future transformative bench-to- bedside bridging of treatment to personalize management and clinical treatment of retinitis pigmentosa.

PI_NAMEs: BERKOWITZ, BRUCE A. (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Acceleration;Address;alpha Subunit Transducin;Atrophic;bench to bedside;Biological Assay;Biological Markers;biomarker performance;Blindness;Cell Culture Techniques;Cessation of life;Clinic;Clinical Treatment;clinically relevant;Cone;dark rearing;Darkness;Diet;Disease;Early Diagnosis;Ecosystem;Electron Microscopy;Etiology;Evolution;Experimental Models;experimental study;Exposure to;Friends;Functional disorder;Future;Genes;Genetic;Histologic;Hour;human model;imaging biomarker;imaging modality;improved;improved outcome;indexing;Inherited;innovation;Knowledge;Light;loss of function mutation;Measurement;Measures;Methylene blue;Mitochondria;mitochondrial dysfunction;Mouse Strains;Mus;Mutation;Names;Natural History;neuroprotection;non-invasive imaging;novel;Nuclear Hormone Receptors;old mice;Onset of illness;Optical Coherence Tomography;Oxygen Consumption;Pathogenicity;Pathology;Patient-Focused Outcomes;Patients;Performance;Periodicity;personalized management;phosphodiesterase 6;phosphoric diester hydrolase;photoreceptor degeneration;postnatal;Prediction of Response to Therapy;prevent;Public Health;Receptor Gene;Reporting;Research;restoration;retinal rods;Retinitis Pigmentosa;Rod;Shapes;Signal Transduction;Synthetic Progestogens;Technology;Testing;Time;Tissues;Transducin;translational barrier;Treatment Efficacy;Treatment outcome;Up-Regulation;Vertebrate Photoreceptors;Vision;Wild Type Mouse

PROJECT_TITLE: Mitigating retinitis pigmentosa based on a non-invasive rod energy-landscape biomarker

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infertility;Patient Safety;Pediatric;Pediatric Cancer;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rare Diseases;Rehabilitation;Rural Health;Social Determinants of Health;Women's Health Research

PI_NAMEs: WILLIAMS, SHILOH A (contact)

PROJECT_TERMS: Adolescent and Young Adult;adverse pregnancy outcome;Aftercare;anti-cancer research;arm;California;cancer care;cancer education;Cancer Patient;Cancer Science;Cancer Survivor;cancer survivorship care;care delivery;Caring;Catchment Area;Clinic;Clinical;clinical care;Communities;Community Clinical Oncology Program;community engagement;Consult;Consultations;Continuity of Patient Care;Contraceptive methods;County;Data;design;Diagnosis;Discipline of Nursing;Distress;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Evaluation;experience;Faculty;feasibility testing;Female Adolescents;Fertility;Focus Groups;Future;Geography;Health;health care delivery;health disparity;health equity;Health Insurance;health literacy;Health Personnel;Health Professional;Healthcare;high risk;Hispanic;Hispanic Populations;hybrid type 1 trial;implementation measures;implementation outcomes;implementation science;improved;Infertility;Intervention;Interview;Latina;Learning;Linguistics;low health literacy;Malignant Neoplasms;medically underserved;Menopausal Symptom;Methods;Mexico;multi-component intervention;multi-site trial;neoplasm resource;Newly Diagnosed;novel;Nursing Faculty;oncofertility;Oncology;outreach;Parents;Pathway interactions;patient navigation;Patients;Pilot Projects;pilot test;Premature Ovarian Failure;primary outcome;psychosocial outcome;Quality of Care;Quality of life;remote communities;Reporting;reproductive;Reproductive Health;Reproductive Medicine;Research;Research Personnel;Resource-limited setting;Resources;Risk;Rural;rural area;Rural Community;rural healthcare;rural Hispanic;screening;shared decision making;Social Work;Social Workers;Spanish;Spanish/English;Specialist;Structure;Survivors;survivorship;telehealth;Underserved Population;Universities;uptake;Work

PROJECT_TITLE: Pilot Project 1:  Creating Bridges to Reproductive Health Care for Rural Adolescent and Young Adult Cancer Survivors


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Esophageal Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Narrative: Esophageal cancer is the 6th leading cause of cancer mortality worldwide. In this renewal, we will build on our prior work developing a low cost, mobile high resolution microendoscope with artificial intelligence to evaluate its performance, acceptability, feasibility and clinical impact in diverse settings in the US and Brazil.

PI_NAMEs: ANANDASABAPATHY, SHARMILA  (contact)

PROGRAM_OFFICER_NAME: GRODZINSKI, PIOTR

PROJECT_TERMS: Adoption;Algorithmic Software;Algorithms;Anus;Area;arm;Artificial Intelligence;automated algorithm;Biopsy;Brazil;Cancer Etiology;Cancer Hospital;cancer prevention;Carcinoma;Cell Nucleus;China;Chinese;chromoscopy;Classification;Clinical;Clinical Research;clinically relevant;Colon;Computer Assisted;Computer software;Computers;contextual factors;cost;COVID-19;Data;Data Set;Death Rate;deep learning;deep learning algorithm;Detection;Devices;Diagnosis;Diagnostic;digital;Dissemination and Implementation;Early Diagnosis;Eastern Africa;Effectiveness;Endoscopy;Environment;Epithelium;esophageal squamous cell neoplasia;Esophagus;Ethnic Origin;Evaluation;experience;Geographic Locations;Goals;handheld mobile device;health literacy;Health Status;high risk;Hospitals;Image;implementation facilitation;improved;Incidence;Inflammatory;innovation;International;Iran;Language;Malignant neoplasm of esophagus;Malignant Neoplasms;microendoscope;microendoscopy;Microscopic;microscopic imaging;Modeling;mortality;Neoplasms;neoplastic;Nuclear;Optical Biopsy;Oral;Participant;patient population;Patients;Performance;Pilot Projects;pilot trial;Population Heterogeneity;portability;Prevention strategy;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;Resolution;Risk;screening;Screening for cancer;Sensitivity and Specificity;simulation;Site;Skin;socioeconomics;South America;Specificity;Speed;standard of care;Stomach;Technology;Testing;Texas;Time;Training;Validation;Veterans Hospitals;Visual;Work

PROJECT_TITLE: AI-Assisted Microendoscopy for the Early Detection of Esophageal Cancer

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: KIROS, GEBRE-EGZIABHER  (contact)

PROJECT_TERMS: Achievement;Address;Advanced Malignant Neoplasm;African American;anti-cancer research;Bioinformatics;Biological;Biometry;Black American;California;cancer health disparity;Cancer health equity;Cancer Research Project;Caring;Clinical;Communities;Community Outreach;Comprehensive Cancer Center;computerized data processing;computing resources;Data;Data Analyses;data cleaning;Data Collection;data management;Data Management Resources;data repository;Data Science;Data Set;data sharing;Data Storage and Retrieval;Databases;design;Development;Doctor of Philosophy;drug development;E-learning;Education;education research;Educational Materials;Educational workshop;Ensure;Environmental Exposure;Evaluation;Event;exome sequencing;experimental study;federated data;Florida;Funding;Future;Gene Expression Profiling;genomic data;Goals;Grant;Health;Health Disparities Research;health equity;high dimensionality;High-Throughput Nucleotide Sequencing;Hispanic;human data;Individual;innovation;Institution;Laboratories;lectures;Malignant Neoplasms;Manuscripts;meetings;member;Methodology;Methods;mortality;Mutation;Mutation Analysis;novel;Occupations;outreach;Pilot Projects;Population;Preparation;Procedures;public database;Publications;Quality Control;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Resources;Schedule;Science;Series;Services;single cell sequencing;software as a service;software development;Source;System;Techniques;Tissue Model;Training;Training Support;transcriptome sequencing;Triage;Underserved Population;Universities;University of Southern California Norris Cancer Center;web site;Work

PROJECT_TITLE: Bioinformatics, Statistical and Methodological Core


ED_INST_TYPE: SCHOOLS OF NURSING

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

PI_NAMEs: HUGHES-HALBERT, CHANITA A.;REAMS, ROMONIA RENEE;REDDA, KINFE KEN;STERN, MARIANA C;WILKIE, DIANA J (contact)

PROJECT_TITLE: 2/3 Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Achievement;Address;Adolescent and Young Adult;Advanced Malignant Neoplasm;Advisory Committees;anti-cancer research;Area;black patient;California;cancer education;cancer health disparity;Cancer health equity;Cancer Patient;Cancer Survivor;care delivery;Career Choice;Catchment Area;Clinical Trials;community advisory board;community engaged research;community partners;County;Data;Development;Disparity;disparity reduction;Documentation;education research;Evaluation;experience;Feedback;Future;Goals;graduate student;health equity;Healthcare Systems;Hispanic Women;improved;improved outcome;Inequity;innovation;Institution;Lead;Leadership;Logic;Malignant Neoplasms;Medical Students;member;Methods;Modeling;Modification;multi-component intervention;multidisciplinary;novel;novel therapeutic intervention;Outcome;Outcome Assessment;Pancreatic Ductal Adenocarcinoma;Patients;Pilot Projects;Policy Maker;Principal Investigator;programs;Provider;Reproductive Health;Research;Research Personnel;Research Project Grants;Resource Sharing;Resource-limited setting;Resources;Rural;Scholars Program;Services;System;telehealth;Testing;undergraduate student;underserved community;Universities

PROJECT_TITLE: Planning and Evaluation Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Orphan Drug;Pancreatic Cancer;Prostate Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Urologic Diseases

PI_NAMEs: FLORES-ROZAS, HERNAN ALCIDES (contact)

PROJECT_TERMS: Address;African American;anti-cancer research;Archives;Basic Science;biobank;Biocompatible Materials;Bioinformatics;Black race;California;cancer health disparity;cancer type;career development;Caring;Cell Line;Chemistry;clinical database;clinical translation;Collaborations;Collection;Complex;Conscious;crosslink;Data;Databases;Development;Development Plans;Disparity;drug development;drug discovery;Education;Ensure;ethnic diversity;Evaluation;experience;FDA approved;First Independent Research Support and Transition Awards;Florida;Funding;Future;genomic data;Genomics;Goals;health equity;Hispanic;Human;Implant;Individual;Institution;Latinx;Latinx population;Lead;Leadership;Link;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Research;member;Mentorship;Methodology;Mission;Modeling;Molecular;neoplasm registry;Normal tissue morphology;novel;Organoids;Outcome;pancreatic cancer patients;Pathologic;patient derived xenograft model;patient population;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pilot Projects;Plasma;Population;Prostate;Race;racial diversity;recruit;repository;Research;research and development;Research Personnel;Research Project Grants;Residual state;Resource Sharing;Resources;response;RNA;Role;Sampling;Scientist;Serum;skills;Specimen;success;Technology;technology development;Testing;Tissue Banks;Tissue Model;Tissue Sample;Tissues;Translational Research;tumor;Tumor Tissue;Universities;virtual

PROJECT_TITLE: Tissue Modeling and Drug Discovery Core


ADMINISTERING_IC: HG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SANTA CRUZ

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative The objective of the proposed study will be to develop innovative methods to reach complete, telomere-to- telomere phased assemblies of human genomes. To reach this milestone we propose technological innovation in both long read sequencing, novel repeat assembly strategies. Fundamental to the success of this project will be the equal emphasis on rigorous assessment of assembly structure and base-level accuracy.

PI_NAMEs: MIGA, KAREN HAYDEN (contact)

PROGRAM_OFFICER_NAME: WETTERSTRAND, KRIS A

PROJECT_TERMS: Address;arm;base;Benchmarking;Biological Assay;Biomedical Research;Cell Line;Cells;Centromere;Chromosomes;cloud based;cohort;Collection;Communities;Complete Hydatidiform Moles;computerized data processing;cost;cost effective;Data;design;Diploidy;Disease;Ensure;Equipment;Evaluation;Funding;Gel;Genetic Variation;Genome;Genome Stability;Genomics;Haploidy;Haplotypes;Health;Hour;Human;Human Chromosomes;Human Genome;human pangenome;human reference genome;improved;Individual;Informatics;Infrastructure;innovation;Length;Manuals;Maps;Measures;Methods;Molecular;nanopore;novel;novel strategies;Optics;Phase;Physiologic pulse;Production;reference genome;Repetitive Sequence;Research;Resolution;Source;Structure;success;Techniques;technological innovation;Technology;telomere;Testing;United States National Institutes of Health;Validation;Variant;whole genome;Work

PROJECT_TITLE: Telomere-to-telomere assemblies of human genomes

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Social Determinants of Health

PI_NAMEs: CRIPPS, RICHARD MATTHEW (contact)

PROJECT_TERMS: Achievement;Advisory Committees;anti-cancer research;Area;Awareness;California;Cancer Biology;Cancer Center;cancer education;cancer health disparity;career;career development;Clinical;cohort;Collaborations;Communication;Communities;community clinic;community engagement;community organizations;Coupled;Dedications;Degree program;Development;Doctor of Philosophy;doctoral student;Education;education research;Educational Activities;effectiveness evaluation;Ensure;Environment;Ethnic Population;Evaluation;experience;Exposure to;Faculty;Fellowship;Financial Support;follow-up;Funding;Future;Goals;graduate student;Grant;Health;Health Disparities Research;health equity;Health equity research;Human Resources;improved;Individual;interest;Joints;Laboratory Research;Leadership;Malignant Neoplasms;Manuscripts;medical schools;Medical Students;Mentors;Mentorship;Modeling;Molecular Chaperones;multidisciplinary;Neighborhood Health Center;operation;Participant;peer;peer coaching;Physicians;pre-clinical;Preparation;programs;Provider;public health research;racial population;recruit;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;Resource Sharing;Scholars Program;Schools;Science;Scientist;social determinants;student participation;Students;success;summer research;Time;Training;Travel;Trinidad;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Work

PROJECT_TITLE: Research Education Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pancreatic Cancer;Racial and Ethnic Minority Health Research;Rare Diseases

PI_NAMEs: ALI, JAMEL  (contact)

PROJECT_TERMS: 3-Dimensional;Acinar Cell;Acinus organ component;Address;African American;African American population;anti-cancer research;biophysical properties;biophysical techniques;Black Populations;Black race;California;Cancer cell line;cancer health disparity;Caring;Cell Line;Cell Reprogramming;Cells;Chronic;chronic pancreatitis;Coculture Techniques;Collagen;combat;comorbidity;Conditioned Culture Media;Data;Development;Disease;Disparity;Duct (organ) structure;Ductal Epithelial Cell;Early Diagnosis;Early treatment;Education;effective therapy;Event;Experimental Models;Extracellular Matrix;Fibronectins;Florida;Funding;Gender;Gene Expression;Genes;Genetic Markers;Goals;health equity;Heterogeneity;Hispanic;Hispanic Populations;Histone Deacetylase Inhibitor;Human;Immune;Immunofluorescence Immunologic;improved;In Situ;Incidence;Individual;Inflammation;Inflammatory;inhibitor;Institution;irritation;Latino;Latino Population;Lesion;Link;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolic stress;Metaplasia;Methods;Microscopic;Molecular;mortality;mouse model;Normal Range;novel;Outcome;Oxidative Stress;Pancreas;pancreas development;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic metaplasia;pancreatic stellate cell;Pathway interactions;Patients;Penetration;Peptide Hydrolases;Pharmaceutical Preparations;pharmacologic;Phenotype;Pilot Projects;prevent;Process;Prognosis;Publishing;Race;racial disparity;Role;Sampling;single cell ATAC-seq;Stains;stellate cell;Stromal Cells;System;therapeutic target;Tissues;transcriptome sequencing;treatment response;Trichostatin A;tumor microenvironment

PROJECT_TITLE: Racial contributions of microenvironment remolding during pancreatic metaplasia


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Currently, there is no effective therapy to treat several retinal degeneration diseases including retinitis pigmentosa and lysosomal storage disease (Batten disease). The proposed studies will uncover novel insights into the basic understanding of how the diseased photoreceptors activate microglia for pathology contribution and the results of these studies will have high potential to develop strategies to ameliorate clinical pathophysiology through modulating neuroinflammation.

PI_NAMEs: SUNG, CHING-HWA  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: 3-Dimensional;Address;Affect;Agreement;Alzheimer's Disease;Antigens;Biological Process;Cathepsins B;Clinical;Communication;Complex;Data;Disease;Disease associated microglia;Disease Progression;disorder subtype;Early Endosome;effective therapy;Electron Microscopy;Electroretinography;Endosomes;Etiology;Eye;Feedback;Flow Cytometry;Functional disorder;Galectin 3;Gene Expression;Generations;Genes;Genetic;Goals;Grant;Heterogeneity;Histologic;Homeostasis;Hot Spot;Impairment;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;insight;interest;Learning;Lesion;Link;lipidomics;Lipids;Lipofuscin;loss of function;Lysosomal Storage Diseases;Lysosomes;Mediating;Membrane;Membrane Lipids;Messenger RNA;Methodology;Microglia;migration;Molecular Profiling;molecular subtypes;mouse model;Mus;Mutant Strains Mice;Nature;Nervous System Disorder;neuroinflammation;Neurons;novel;novel therapeutic intervention;Ophthalmoscopy;Parkinson Disease;Pathologic;Pathology;Pathway interactions;Peptide Hydrolases;Peptide Initiation Factors;Phagocytes;Phagocytosis;Phagosomes;Photoreceptors;Probability;Proteins;Resolution;Retina;Retinal Degeneration;Retinal Diseases;retinal rods;Retinitis Pigmentosa;Retinoids;Rhodopsin;Rod;Role;Rupture;Signal Transduction;Sphingolipids;Spielmeyer-Vogt Disease;Stimulus;Structure of retinal pigment epithelium;Synapses;Synaptic Membranes;System;Techniques;Testing;tool;trafficking;transcriptome;transcriptomics;wasting

PROJECT_TITLE: Endosome regulated retinal homeostasis and disease

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Liver Cancer;Liver Disease;Lung;Lung Cancer;Orphan Drug;Patient Safety;Rare Diseases;Skin Cancer

ORG_NAME: 7 HILLS PHARMA, LLC

PHR: PROJECT NARRATIVE A significant proportion of solid tumor patients are resistant to anti-PD-1 immune checkpoint therapy, largely due to insufficient priming and trafficking of tumor-targeted T cells. 7HP349 is an allosteric agonist of α4β1 and αLβ2 integrins that has shown enhanced T cell priming and activation, antitumor efficacy and survival in tumor models with increased T cell infiltration into tumors, and has the potential to significantly increase response rates in patients resistant to anti-PD-1 immune checkpoint therapy. This proposal is for a Phase Ib clinical study to evaluate 7HP349 in combination with anti-CTLA-4 followed by anti-PD-1 immune checkpoint blockade in solid tumor patients with secondary resistance to anti-PD-1.

PI_NAMEs: LEWIS, LIONEL DAVID;MARATHI, UPENDRA  (contact);SCHARY, WILLIAM

PROJECT_TERMS: Adverse event;Agonist;anaplastic lymphoma kinase;anti-CTLA4;anti-PD-1;anti-PD1 therapy;Antigen Presentation;autoimmune toxicity;Binding;Biopsy;Capital;checkpoint therapy;Clinical Research;Colorectal Cancer;Consensus;design;Development;Dose;Dose Limiting;Drug Kinetics;Effectiveness;Epidermal Growth Factor Receptor;first-in-human;Food;Foundations;Funding;Future;Genomics;Goals;immune checkpoint blockade;Immune checkpoint inhibitor;Immunooncology;immunotoxicity;improved;In complete remission;In Vitro;in vitro activity;Integrin alpha4beta1;Integrins;ipilimumab;Maintenance;Malignant neoplasm of lung;Mediating;Medical;Melanoma;Melanoma patient;Metastatic Melanoma;migration;Mismatch Repair Deficiency;Modeling;Nivolumab;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;novel;objective response rate;Oral;Orphan Drugs;Overdose;partial response;Patients;pembrolizumab;pharmacologic;Phase;phase 1 study;Pleural Mesothelioma;Primary carcinoma of the liver cells;Privatization;Progressive Disease;Recommendation;Regimen;Renal Cell Carcinoma;Resistance;response;risk mitigation;Safety;safety study;Sampling;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Solid Neoplasm;Stable Disease;standard of care;T cell infiltration;T cell response;T-Cell Activation;T-Lymphocyte;Toxic effect;trafficking;tumor

PROJECT_TITLE: 7HP349, an Integrin Activator to Treat Patients With anti-PD-1 Resistant Solid Tumors


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: MCDANIELS, CORINNE RAE (contact)

PROJECT_TERMS: Address;Adopted;Advanced Malignant Neoplasm;agricultural community;Alaska Native population;American Indian Population;anti-cancer research;Area;Asian population;Black Populations;California;cancer care;cancer education;cancer health disparity;Cancer health equity;Caring;Catchment Area;Collaborations;collaborative approach;Communities;community advisory board;community building;community collaboration;community engaged research;community engagement;Community Health Systems;community organizations;community partnership;County;Data;design;Development;Diagnosis;Diffusion;Disparity;Early Diagnosis;Education;Education and Outreach;education research;Educational workshop;Ensure;ethnic diversity;Ethnic Population;Evaluation;Evidence based practice;experience;Fostering;Geographic Locations;Goals;graduate student;health equity;Health equity research;Hispanic Populations;implementation science;improved;Individual;Infusion procedures;innovation;Institution;Intervention;Investments;Leadership;Linguistics;Malignant Neoplasms;Medical Students;medically underserved;Methodology;Mexico;Minority;Mission;Modeling;multidisciplinary;NCI-Designated Cancer Center;Needs Assessment;Neighborhood Health Center;Not Hispanic or Latino;outreach;Pacific Islander;Pathway interactions;Patients;Population;Positioning Attribute;Prevention;programs;Race;racial population;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;Resource Sharing;Resources;Risk Factors;Rural;screening;Screening for cancer;student participation;survivorship;Teacher Professional Development;Training;undergraduate student;underserved community;Underserved Population;Voice;web platform;Work

PROJECT_TITLE: Outreach Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Orphan Drug;Racial and Ethnic Minority Health Research;Rare Diseases;Tobacco;Tobacco Smoke and Health

PI_NAMEs: LAMANGO, NAZARIUS SAAH (contact)

PROJECT_TERMS: 3-Dimensional;Address;Affect;African American;African American population;alpelisib;Alveolar;alveolar epithelium;Amides;Angiogenesis Inhibition;anti-cancer research;anti-cancer therapeutic;BAY 54-9085;Bioinformatics;Biological;Biological Factors;Biological Models;Biomedical Engineering;Black American;black men;Black Populations;Black race;black women;bone;BRAF gene;Bronchiolo-Alveolar Adenocarcinoma;California;cancer cell;cancer health disparity;Carcinogens;Caring;Cell Line;Cell Survival;Cells;Collection;Combined Modality Therapy;cytotoxicity;Data Analyses;Development;Disparity;DNA;Doctor of Philosophy;driver mutation;Drug Combinations;drug development;Education;effective therapy;Epidermal Growth Factor Receptor;Epithelial Cells;Erlotinib;Ethnic Origin;Ethnic Population;exome sequencing;exposure to cigarette smoke;Florida;follow-up;Formalin;Funding;Gel;Gelatin;Gene Mutation;Genes;Genetic;Growth;health disparity;health equity;high risk;In Vitro;in vitro Model;Individual;Inhalation;inhibitor;innovation;interdisciplinary collaboration;Invaded;Knowledge;KRAS2 gene;Leukocytes;Lung Adenocarcinoma;Malignant Bone Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;MAP Kinase Gene;Measures;Medicine;member;men;Metabolism;Metastatic Neoplasm to the Bone;Methodology;Methods;migration;Modeling;Molecular;mutant;Mutate;Mutation;Neoplasm Metastasis;neoplasm registry;Nicotine;novel;novel therapeutics;Organoids;osteogenic;Paraffin Embedding;Pathway interactions;Patients;Pattern;Perfusion;Pharmaceutical Preparations;PIK3CG gene;Porosity;Printing;progenitor;Race;racial difference;racial population;Resources;response;Risk Factors;Sampling;Site;Source;STK11 gene;System;targeted treatment;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Time;Tissue Model;Tobacco smoke;tool;TP53 gene;Treatment Efficacy;treatment response;two-dimensional;Variant;Vascular Endothelial Cell;Woman;Work

PROJECT_TITLE: Full Project 2 - An Organoid System Tailored to Study Lung Cancer in Blacks


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative We will study how survival after transplantation can be improved through a better understanding of variants in the genes of the immune system, and the different combinations of variants that are inherited from one’s parents. This information will help to lower risks through individualized treatment options for future patients.

PI_NAMEs: PETERSDORF, EFFIE W (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Acute;African;Alleles;Allogenic;Area;Asian;Binding;Biological;Caucasians;Cells;Chronic;Clinical;clinically relevant;clinically significant;Complex;conditioning;Cyclophosphamide;Data;Disease-Free Survival;Donor person;Donor Selection;Equilibrium;Ethnic Origin;Failure;Future;Genes;Germ Lines;Goals;graft failure;Graft Rejection;graft vs host disease;Haplotypes;Hematological Disease;Hematopoietic Stem Cell Transplantation;high risk;Hispanic;HLA-B Antigens;HLA-DQ Antigens;Human Genome;Immune response;Immune system;Immunobiology;Immunogenetics;improved;improved outcome;Individual;individualized medicine;Inherited;Ligands;Link;Malignant - descriptor;Maps;Methods;Mica;Modeling;Molecular Chaperones;Monitor;Morbidity - disease rate;mortality;novel;novel strategies;Outcome;outcome prediction;Parents;Pathway interactions;Patients;Peptide Leader Sequences;Peptides;Phase;Play;Population Heterogeneity;post-transplant;Proteins;Race;racial diversity;Regimen;Relapse;relapse risk;Risk;Risk Assessment;risk mitigation;Role;Shapes;Source;stem cells;Structure;survivorship;synergism;System;Translations;Transplant Recipients;Transplant-Related Disorder;Transplantation;Umbilical Cord Blood Transplantation;Variant

PROJECT_TITLE: Clinical Significance of MHC Haplotypes in HCT

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative While the majority of PDAC patients will develop metastatic disease, the organ specific immunology and biology of these metastatic lesions is poorly understood. These understandings are critical for the treatment of metastatic PDAC patients. This proposal will study the impact of metastatic disease on dendritic cells using human patient samples and model systems.

PI_NAMEs: DENARDO, DAVID G (contact);DING, LI ;FIELDS, RYAN C

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Address;Animal Model;Atlases;Biological Models;Biology;Bone Marrow;Cells;checkpoint therapy;chemotherapy;Clinical;conventional therapy;Correlative Study;Cross Presentation;cytotoxic;Data;Dendritic Cells;density;Development;Disease;Exclusion;Functional disorder;Genetic;Genomics;Goals;Human;human tissue;Imaging Techniques;Immune;Immune checkpoint inhibitor;Immunity;Immunology;Immunotherapeutic agent;Immunotherapy;Impairment;Infiltration;Institution;Lead;Limes;Link;Location;Malignant neoplasm of pancreas;Malignant Neoplasms;mouse model;multiple omics;Myeloid Cells;Myeloid-derived suppressor cells;Myelopoiesis;Nature;Neoplasm Metastasis;Organ;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Patients;Phenotype;Primary Neoplasm;Prior Therapy;Process;Productivity;Prognosis;programs;prospective;Publishing;Refractory;Reporting;Research;response;Sampling;Shapes;Site;Stromal Cells;T cell infiltration;T cell response;Testing;Tissue Banks;Tissue Model;Tissue Sample;tumor;Tumor Antigens;Tumor Biology;Tumor Immunity;tumor microenvironment;tumor-immune system interactions

PROJECT_TITLE: The Impact of Metastatic Site On Dendritic Cell-Driven Tumor Immunity


PI_NAMEs: WILKIE, DIANA J (contact)

PROJECT_TITLE: Administrative Core - 2/3 Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Natural Products

ORG_CITY: STONY BROOK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: The botulinum neurotoxins are some of the deadliest known yet are also revered for their pharmaceutical utility. These toxins are marvels of protein evolution able to inject a toxic cargo enzyme into a specific cell type using a self-contained delivery system. Our unique combination of expertise in single molecule imaging, molecular simulations and protein-engineering will allow us to answer long- standing questions about the delivery mechanism by overcoming the structural heterogeneity that challenged previous studies.

PI_NAMEs: BOWEN, MARK E (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: biophysical techniques;Biophysics;Botulinum Toxins;C-terminal;cell type;Cellular Membrane;Cholera Toxin;Classification;Clinical;Clinical Trials;clinically relevant;Clostridium botulinum;Cosmetics;Crystallization;Data;Development;Diphtheria Toxin;Drug Kinetics;Electron Microscopy;Electrophysiology (science);Endosomes;Enzymes;Evolution;Family;Fluorescence;Fluorescence Resonance Energy Transfer;Goals;Heterogeneity;Imaging technology;Individual;innovation;interest;Intoxication;Investigation;Ion Channel;Knowledge;Left;Life;Light;Link;Liposomes;man;Marketing;member;Membrane;Membrane Lipids;Methods;Modeling;Molecular;Molecular Conformation;molecular imaging;N-terminal;nanobodies;Neurons;Neurotoxins;next generation;novel;novel strategies;Peptide Hydrolases;Pharmacologic Substance;Physiological;preservation;prevent;Process;Protein Dynamics;Protein Engineering;Protein Isoforms;Proteins;Publishing;Reaction;Reagent;receptor;receptor binding;sensor;Serotyping;simulation;single molecule;single-molecule FRET;stoichiometry;structural biology;Structure;System;Techniques;Tetanus Toxin;Time;Toxin;Visit

PROJECT_TITLE: Resolving the intoxication mechanism of botulinum neurotoxins using single molecule structural biology

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nanotechnology;Orphan Drug;Pancreatic Cancer;Racial and Ethnic Minority Health Research;Rare Diseases

PI_NAMEs: AGYARE, EDWARD KWASI (contact)

PROJECT_TERMS: Address;African American population;anti-cancer research;anticancer activity;Black Bear;Black race;California;Cancer Etiology;Caring;Cells;Cessation of life;chemotherapy;cohort;Cytidine Deaminase;Data Set;DCK gene;Deoxycytidine Kinase;design;Development;Diagnosis;Drug Kinetics;Drug usage;Education;efficacy evaluation;efficacy testing;enzyme activity;Epidermal Growth Factor Receptor;Epigenetic Process;ethnic diversity;experience;experimental study;Exposure to;Fc Receptor;Florida;Fluorouracil;Formulation;gemcitabine;Gene Expression;Genetic;Goals;health equity;High Prevalence;Hispanic;Human;improved;in vivo;Incidence;Investigation;irinotecan;Knowledge;Latinx;Latinx population;Leucovorin;Link;lipophilicity;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Metabolism;Modeling;mortality;mouse model;multi-ethnic;Mus;nanoparticle;novel;Nucleoside Transporter;Operative Surgical Procedures;Organoids;Outcome;oxaliplatin;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic neoplasm;patient derived xenograft model;patient stratification;Patients;Pattern;personalized chemotherapy;Phosphorylation;Pilot Projects;Population;Population Heterogeneity;protein expression;Proteins;Publishing;racial difference;racial diversity;Resistance;response;RNA;Safety;Sampling;SNP genotyping;Solubility;subcutaneous;Surface;Survival Rate;Systemic Therapy;targeted delivery;Testing;therapy outcome;Toxic effect;treatment choice;Treatment Efficacy;tumor;tumor growth;tumor xenograft;uptake;Variant;Wild Type Mouse

PROJECT_TITLE: Development and Testing of a Novel Biospecific using modified Gemcitibine to target and treat Pancreatic Cancer


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Data Science;Diabetes;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: GABORONE

ORG_COUNTRY: BOTSWANA

ORG_FIPS: BC

ORG_NAME: UNIVERSITY OF BOTSWANA

PHR: Project Narrative Timely detection and early intervention of Metabolic Syndrome (MetS) can prevent the progression to type 2 diabetes and cardiovascular disease. Similarly, non-sputum diagnostic biomarkers of active tuberculosis (TB) can facilitate the development of highly sensitive point-of-care diagnostics. However, access and utilization of data science methodologies has been limited in ethnically diverse HIV-infected pediatric communities in Africa. To promote the utility of highly sensitive predictive and diagnostic tools of MetS and TB, we propose a collaborative data science project that integrates temporal electronic health records with multi-omics data. This initiative will provide clinicians with a new tool to increase TB and MetS screening rates, reduce screening wait times and promote timely interventions among HIV-infected children.

PI_NAMEs: KYOBE, SAMUEL ;RETSHABILE, GAONE  (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: 15 year old;Acquired Immunodeficiency Syndrome;Address;Adolescence;Adolescent;Adult;Advanced Development;adverse outcome;Africa;Africa South of the Sahara;African;Age;Algorithms;antiretroviral therapy;Artificial Intelligence;Bacteriology;Biochemical Pathway;Biological Markers;Botswana;Cardiovascular Diseases;Cause of Death;Characteristics;Child;Childhood;Classification;Clinical;clinical center;clinical decision-making;clinical heterogeneity;clinically relevant;co-infection;cohort;Collaborations;Communities;Community Healthcare;Complex;Complications of Diabetes Mellitus;Continuity of Patient Care;Data;Data Science;Detection;Development;Diabetes Mellitus;Diagnosis;Diagnostic;diagnostic algorithm;diagnostic assay;diagnostic biomarker;diagnostic tool;digital;Disease;Disease Progression;Early Intervention;electronic health database;Electronic Health Record;ethnic diversity;explainable machine learning;Future;Generations;Genes;Genetic;Genetic Predisposition to Disease;genomic data;Genomics;Goals;Health;Heterogeneity;high risk;HIV;HIV/TB;Hypertension;Impairment;improved;improved outcome;Incidence;Individual;Infection;International;Intervention;Knowledge;Laboratories;Learning;Life Expectancy;Link;Longitudinal Studies;Machine Learning;machine learning algorithm;Mentors;Metabolic;metabolic profile;Metabolic syndrome;Methodology;Methods;Modeling;Molecular Profiling;Morbidity - disease rate;mortality;mortality risk;multi-ethnic;multidisciplinary;multimodal data;Multiomic Data;multiple omics;Nature;neural network algorithm;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Patients;pediatric human immunodeficiency virus;pediatric human immunodeficiency virus infection;Perinatal;Persons;pharmacologic;Phenotype;point-of-care diagnostics;Population;Positioning Attribute;predictive modeling;predictive tools;prevent;Prevention;Probability;programs;public health intervention;Radiology Specialty;Research;Research Personnel;Resources;Risk;Risk Factors;risk prediction;risk stratification;Role;screening;skills;standard of care;Subgroup;Technology;Testing;Thoracic Radiography;tool;transcriptomics;Translating;translational potential;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;Uganda;Validation;Vertical Disease Transmission;Wait Time

PROJECT_TITLE: DSpace: Utilizing Data Science to Predict and Improve Health Outcomes in Pediatric HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-L(70)R]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SMITH, UKAMAKA D. (contact)

PROJECT_TERMS: Accountability;Achievement;Advocate;African American;Annual Reports;anti-cancer research;Award;Benchmarking;Black race;California;cancer health disparity;career development;Career Mobility;Caring;Collaborations;Communities;Community Health Education;Community Outreach;Data;Decision Making;design;Development;Doctor of Pharmacy;Doctor of Philosophy;Documentation;Education;Education and Outreach;education research;Educational workshop;Effectiveness;Ensure;Evaluation;Exhibits;Extramural Activities;Faculty;Florida;Fostering;Funding;Goals;Grant;Health Disparities Research;health equity;Hispanic;implementation evaluation;improved;Individual;inter-institutional;Investments;Latino;Leadership;Measures;meetings;member;Mentors;minority trainee;Monitor;multidisciplinary;Online Systems;Outcome;Outcome Assessment;Pathway Analysis;Peer Review;Population;Process;Program Evaluation;programs;Publications;Quantitative Evaluations;Recommendation;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resource Allocation;Resource Sharing;Resources;Scholarship;Science;Scientist;Social Network;success;Surveys;symposium;Training;Underrepresented Minority;Universities;webinar


PI_NAMEs: LEE, JI-HYUN  (contact)

PROJECT_TITLE: Bioinformatics, Statistical and Methodological Shared Resources Core


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BALTIMORE

ORG_NAME: FRIENDS RESEARCH INSTITUTE, INC.

ORG_STATE: MD

PHR: PROJECT NARRATIVE Black and Latinx people who use opioids are disproportionately impacted by opioid overdose deaths. The proposed study assesses the efficacy of an open source, multimodal artificial intelligence-driven texting tool combined with peer recovery coach-supported text contact that delivers social services, stigma reduction, health habitus, and patient navigation content addressing social determinants of health to enhance receipt of buprenorphine in primary care among emergency department-enrolled Black / Latinx people who use opioids.

PI_NAMEs: LEKAS, HELEN-MARIA ;LEWIS, CRYSTAL FULLER;TOFIGHI, BABAK  (contact)

PROGRAM_OFFICER_NAME: KATO, ELISABETH

PROJECT_TITLE: Leveraging social determinants via artificial intelligence and peer coaching to address racial disparities in primary care among people who use opioids


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Orphan Drug;Pancreatic Cancer;Racial and Ethnic Minority Health Research;Rare Diseases

PI_NAMEs: OKUNIEFF, PAUL  (contact)

PROJECT_TERMS: Address;African American;anti-cancer research;Archives;Basic Science;biobank;Biocompatible Materials;Bioinformatics;Black race;California;cancer health disparity;cancer type;career development;Caring;Cell Line;Chemistry;clinical database;clinical translation;Collaborations;Collection;Complex;Conscious;crosslink;Data;Databases;Development;Development Plans;Disparity;drug development;Education;Ensure;ethnic diversity;Evaluation;experience;FDA approved;First Independent Research Support and Transition Awards;Florida;Funding;Future;genomic data;Genomics;Goals;health equity;Hispanic;Human;Implant;Individual;Institution;Latinx;Latinx population;Lead;Leadership;Link;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Research;member;Mentorship;Methodology;Mission;Modeling;Molecular;neoplasm registry;Normal tissue morphology;novel;Organoids;Outcome;pancreatic cancer patients;Pathologic;patient derived xenograft model;patient population;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pilot Projects;Plasma;Population;Prostate;Race;racial diversity;recruit;repository;Research;research and development;Research Personnel;Research Project Grants;Residual state;Resource Sharing;Resources;response;RNA;Role;Sampling;Scientist;Serum;skills;Specimen;success;Technology;technology development;Testing;Tissue Banks;Tissue Model;Tissue Sample;Tissues;Translational Research;tumor;Tumor Tissue;Universities;virtual

PROJECT_TITLE: Tissue Modeling & Drug Development Shared Resources Core


PI_NAMEs: MOCHONA, BEREKET - (contact)

PROJECT_TERMS: Academy;Achievement;Address;Admission activity;Advanced Malignant Neoplasm;African American;anti-cancer research;Applications Grants;Applied Research;Award;Basic Science;Behavioral;Behavioral Research;Benchmarking;Bioinformatics;Biomedical Research;Biometry;Black Populations;Black race;California;cancer health disparity;Cancer health equity;career;Career Choice;career development;Caring;Clinical;Clinical Research;Collaborations;Communities;Comprehensive Cancer Center;cost;Data;Discipline;Discipline of Nursing;Doctor of Philosophy;Education;education research;Educational Activities;Engineering;Ensure;Environment;ethnic diversity;Ethnic Origin;Evaluation;experience;Fellowship;Florida;Funding;Genomics;Goals;Government;graduate student;Grant;Health;health care disparity;Health Disparities Research;health equity;Health Professional;Healthcare Systems;higher education;Hispanic;Historically Black Colleges and Universities;Immersion;Impact evaluation;improved;Individual;Institution;interest;International;K-Series Research Career Programs;Knowledge;Latino;Latino Population;Malignant Neoplasms;Manuscripts;medical schools;Medicine;meetings;Mentors;Mentorship;Minority Graduate Student;Minority Groups;minority trainee;Modeling;Monitor;multidisciplinary;Native American Tribe;Oncology;Outcome;Outcomes Research;Patients;peer;Pharmacy facility;Population;Population Research;Postbaccalaureate;Postdoctoral Fellow;posters;pre-clinical;pre-doctoral;Process;Program Evaluation;programs;Public Health;Publishing;Publishing Peer Reviews;Race;racial diversity;recruit;Research;Research Personnel;Research Training;response;Science;Scientist;Site;Structure;Students;success;Training;training opportunity;Training Programs;Training Support;Tribal group;undergraduate student;Underrepresented Minority;United States National Academy of Sciences;United States National Institutes of Health;Universities;University of Southern California Norris Cancer Center


PI_NAMEs: SCHMITTGEN, THOMAS D. (contact)

PROJECT_TITLE: Project 3 ADM


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: MINNEAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE There is an urgent need for objective biomarkers of disease progression that are sensitive to disease related changes over the duration of clinical trials in ALS. Based on our recent work on multimodal MRI in ALS, demonstrating sensitivity to change over six and twelve months, we propose a multi-site study to further optimize, validate, and demonstrate its clinical trial readiness. We will also correlate the MRI metrics with functional progression and plasma neurofilament light. 1

PI_NAMEs: LENGLET, CHRISTOPHE ;PISHARADY, PRAMOD KUMAR (contact);WALK, DAVID

PROGRAM_OFFICER_NAME: KAPOOR, SHELLY

PROJECT_TITLE: Multimodal longitudinal imaging of brain and cervical cord as an ALS disease biomarker using microstructure statistics and morphometry


ORG_DEPT: FAMILY MEDICINE

PHR: PROJECT NARRATIVE Over a third of U.S. adults have unhealthy substance use but primary care clinicians rarely routinely screen for and address unhealthy substance use in a whole person approach that would effectively reduce substance use and improve health. Our study engages primary care practice champions and patients in codesigning and implementing a comprehensive, whole person approach to identifying and addressing unhealthy substance use that accounts for the psychological, social and biological contributors to substance use.

PI_NAMEs: KEISER, BRENNAN ;TONG, SEBASTIAN  (contact)

PROGRAM_OFFICER_NAME: SIMPSON, MATTHEW

PROJECT_TITLE: Supporting Unhealthy Substance use care Through a whole person Approach and user centered INtegration into primary care (SUSTAIN)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

PI_NAMEs: SUTHER, SANDRA G (contact)

PROJECT_TERMS: Academy;Adult;Advisory Committees;Advocacy;Advocate;African American;anti-cancer research;behavior change;Benchmarking;Black American;Black church;Black Populations;Black race;California;cancer health disparity;cancer risk;Cancer Survivor;Caring;catalyst;Church;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community advisory board;community engaged research;Community Outreach;community-centered;Comprehensive Cancer Center;Country;Data;design;Development;Diagnosis;Diffusion of Innovation;Education;education research;Educational Activities;Educational Materials;Evaluation;evidence base;experience;Feedback;Florida;Funding;General Population;Goals;handbook;Health;health belief;health equity;Health Professional;Hispanic;Human;improved outcome;Individual;innovation;Institution;Knowledge;Latino;low socioeconomic status;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;member;men;Mission;Modeling;Multimedia;Pancreas;Persons;Policy Maker;Population;Population Heterogeneity;programs;Prostate;Reporting;Research;Research Personnel;Research Project Grants;Resources;Risk;Scientist;Spanish/English;Technology;Theoretical model;theories;tool;Training;Training Programs;Universities;University of Southern California Norris Cancer Center;Voice;web site;webinar;Work;Writing

PROJECT_TITLE: Community Outreach Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: Chicago

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Niemann-Pick Type C (NPC) disease is a lysosomal storage disorder with no cure or approved treatment. This project will seek to establish a panel of biomarkers in NPC that can be used for future clinical trials.

PI_NAMEs: COLOGNA, STEPHANIE M (contact)

PROGRAM_OFFICER_NAME: MUELLER, CHRISTINE

PROJECT_TITLE: Clinically Relevant Biomarkers for Niemann-Pick Type C


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cancer Genomics;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Human Genome;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This project will develop and validate a method to integrate blood, imaging, and clinical data for the early detection of liver cancer. This test could fill an urgent demand to benefit patients, who are at risk of developing liver cancer.

PI_NAMEs: AGOPIAN, VATCHE ;FRENCH, SAMUEL WHEELER;HAN, STEVEN-HUY B;ZHOU, XIANGHONG JASMINE (contact)

PROGRAM_OFFICER_NAME: FU, SIDNEY WANG

PROJECT_TERMS: Address;Alcohol abuse;bioinformatics tool;Biological Assay;Biological Markers;bisulfite sequencing;Blood;Blood specimen;Cancer Detection;Cancer Etiology;cell free DNA;Cessation of life;Cirrhosis;Classification;Clinical;Clinical Data;cohort;Collaborations;Copy Number Polymorphism;cost;cost effective;Data;data modalities;Detection;detection method;Development;Diagnostic;DNA;DNA Methylation;DNA methylation profiling;Early Diagnosis;Enrollment;epigenomics;Etiology;exosome;Funding;genome wide methylation;Goals;Grant;Hepatitis B Virus;Image;Immune;improved;Incidence;Learning;Libraries;Liver diseases;Longitudinal cohort;Magnetic Resonance Imaging;Malignant neoplasm of liver;Malignant Neoplasms;Methods;methylome;microbial composition;Modeling;Molecular;mortality;multidisciplinary;multimodal data;multimodal modeling;multimodality;multiple omics;Names;Nodule;Obesity;participant enrollment;Patients;Performance;Phase;Preparation;Primary carcinoma of the liver cells;prospective;Prospective cohort;Proteins;Protocols documentation;Research;Resources;Retrospective cohort;Risk;RNA;Scanning;screening;Screening for cancer;Screening for Hepatocellular Cancer;Site;Structure;technology validation;Testing;Training;training data;translational scientist;ultrasound;Validation;whole genome

PROJECT_TITLE: The UCLA Center in Early Detection of Liver Cancer


PI_NAMEs: HUANG, YONG  (contact)

PROJECT_TITLE: Project 4 LUNG


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The proposed Center for Cancer Systems Therapeutics (CaST) will seek to perform systematic, single-cell- level elucidation of stable cell states and state transitions in tumor-related cells and in their tumor microenvironment (TME) to identify and target complementary dependencies leading to mechanism-based combination therapy trials. This will provide a more holistic understanding of the fundamental steps underlying tumor initiation and progression and of the critical mechanisms that can be targeted pharmacologically to transform cancer treatment. Critically, we have shown that the Systems Biology framework developed by CaST Center investigators can effectively generalize to virtually any tumor of interest leading to highly innovative, biomarker-based interventional trials, thus accelerating progression from biological analysis to cures.

PI_NAMEs: CALIFANO, ANDREA  (contact);HONIG, BARRY H

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Acceleration;actionable mutation;Address;Advanced Malignant Neoplasm;Behavior;Binding;Biological;Biological Markers;Buffers;cancer cell;Cancer Center;cancer therapy;cell type;Cells;Clinical;clinical translation;clinically relevant;Collaborations;Combined Modality Therapy;Dependence;design;Development;Disease-Free Survival;Dissection;drug mechanism;Drug resistance;Education;Endocrine;Epigenetic Process;Event;evidence base;forging;Fostering;Genetic;Genetic Transcription;Goals;immune checkpoint blockade;Immunotherapy;improved;Individual;innovation;interest;Intervention;Intervention Trial;Ligands;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mediating;Melanoma;Metastatic malignant neoplasm to brain;Methodology;Molecular;multiple data sources;multiple omics;Mutation;Network-based;next generation;Non-Malignant;Non-Small-Cell Lung Carcinoma;novel;Outcome;outreach;paracrine;patient responsibilities;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenotype;Printing;Productivity;Prognosis;programs;Proteome;Proteomics;Publications;receptor;receptor-mediated signaling;recruit;relapse patients;Research;Research Personnel;Reverse engineering;Science;Scientist;Signal Transduction;single cell technology;Structure;System;Systems Biology;Systems Integration;targeted treatment;Technology;Therapeutic;Therapy trial;three dimensional structure;Tissues;tumor;tumor heterogeneity;tumor initiation;tumor microenvironment;tumor progression;tumor-immune system interactions;Validation;virtual


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE As neurodegenerative diseases have substantial heterogeneity in clinical presentation and no effective cures, Natural history studies (NHS) are essential to enhance our understanding of the disease, find external matching controls, identify people living with rare and ultra-rare forms of the diseases, and bring them into clinical research. Current “traditional” models of NHS in ultra-rare diseases try to search for people living with those conditions “under the lamppost” of the participating clinics, while a decentralized model with utilization of a disease-agnostic people-centric platform, NeuroPRO™, with digital biomarkers’ capture and periodic home or nearest clinical hubs visits will be more efficient in ultra-rare diseases like PLS or familial ALS. We propose to pilot NeuroPRO in three diverse settings that will cover majority of decentralized research models:  • A stand-alone patient-centric longitudinal NHS utilizing digital biomarkers and, if required, periodic home  or nearest clinical hubs visits,  • A hybrid NHS, in which patient-facing NeuroPRO and a “traditional” site-based NHS recruit participants  and capture data as equal partners, and  • NeuroPRO serving as a regulatory compliant environment for rapid simultaneous validation of digital  biomarkers against “standard” disease-specific biomarkers and outcomes.

PI_NAMEs: SHERMAN, ALEXANDER V (contact)

PROGRAM_OFFICER_NAME: XU, LEI

PROJECT_TITLE: Creating a disease-agnostic scalable platform for decentralized observational and validation of digital biomarkers studies and piloting it for people with familial ALS and ultra-rare MNDs


PI_NAMEs: ROGERS, SHERISE C. (contact)

PROJECT_TERMS: Address;African American population;anti-cancer research;anticancer activity;Black Bear;Black race;California;Cancer Etiology;Caring;Cells;Cessation of life;chemotherapy;cohort;Cytidine Deaminase;Data Set;DCK gene;Deoxycytidine Kinase;design;Diagnosis;Drug Kinetics;Drug usage;Education;efficacy evaluation;efficacy testing;enzyme activity;Epidermal Growth Factor Receptor;Epigenetic Process;ethnic diversity;experience;experimental study;Exposure to;Fc Receptor;Florida;Fluorouracil;Formulation;gemcitabine;Gene Expression;Genetic;Goals;health equity;High Prevalence;Hispanic;Human;improved;in vivo;Incidence;Investigation;irinotecan;Knowledge;Latinx;Latinx population;Leucovorin;Link;lipophilicity;Malignant Neoplasms;Measures;Metabolism;Modeling;mortality;mouse model;multi-ethnic;Mus;nanoparticle;Nucleoside Transporter;Operative Surgical Procedures;Organoids;Outcome;oxaliplatin;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic neoplasm;patient derived xenograft model;patient stratification;Patients;Pattern;personalized chemotherapy;Phosphorylation;Pilot Projects;Population;Population Heterogeneity;protein expression;Proteins;Publishing;racial difference;racial diversity;Resistance;response;RNA;Safety;Sampling;SNP genotyping;Solubility;subcutaneous;Surface;Survival Rate;Systemic Therapy;targeted delivery;Testing;therapy outcome;Toxic effect;treatment choice;Treatment Efficacy;tumor;tumor growth;tumor xenograft;uptake;Variant;Wild Type Mouse

PROJECT_TITLE: Pilot Project 5


ORG_CITY: HYATTSVILLE

ORG_NAME: MEDSTAR HEALTH RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE The Improving Diagnostic Equity in Ambulatory care Settings (I.D.E.A.S.): Research to Practice study is designed to evaluate diagnostic errors in the context of diagnostic equity and diagnostic uncertainty through the application of decision-modeling and human factors methodologies. IDEAS: Research to Practice will produce data to understand the extent to which diagnostic inequities occur in the ambulatory setting and their root causes. Our anticipated findings serve as the first step in designing interventions to support clinicians and patients in recognizing potential diagnostic errors, connecting risk factors and their interactions to disproportionately experienced diagnostic errors caused by system-level challenges in diagnostic decision-making processes.

PI_NAMEs: GALLAGHER, WILLIAM J;MILLER, KRISTEN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: HAUGSTETTER, MONIKA


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: NARRATIVE We propose to test an innovative model connecting clinical settings serving historically marginalized communities with early childhood educational services for preschool-age children with developmental delays and disabilities. In doing so, our study aims to improve access to educational and therapeutic services which foster developmental skills and improve health outcomes for families and their children with developmental delays and disabilities.

PI_NAMEs: SHAH, RESHMA  (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: 5 year old;Acceleration;Address;arm;Black race;Brain;care systems;Caregivers;Caring;Characteristics;Child;Child Care;Child health equity;Child Rearing;child services;Childhood;Chronic Care;Cities;Clinic;Clinical;clinical care;Communities;community clinical linkage;critical period;Data Collection;design;Development;Developmental Delay Disorders;Developmental Disabilities;Documentation;early childhood;Economics;Education;education access;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation hybrid;Eligibility Determination;Evaluation;evidence base;Failure;Family;Fostering;group intervention;Guidelines;Health;health care disparity;health equity promotion;Health Insurance;Health Services;Hispanic;implementation evaluation;implementation measures;implementation outcomes;Improve Access;improved;Income;Inequity;innovation;Intervention;intervention effect;Interview;Knowledge;Low income;lower income families;marginalized community;Measures;Mediating;Mediator;Medical Education;Mental Health;Methods;Modeling;Morbidity - disease rate;neighborhood safety;Not Hispanic or Latino;novel;Nursery Schools;Outcome;Parents;Participant;patient centered medical home;peer;pilot test;Preventive care;primary outcome;Quality of life;Randomized;Recommendation;Research;resilience;School Health Services;School-Age Population;Scientific Advances and Accomplishments;secondary outcome;service delivery;Services;skills;social;social health determinants;Stress;Structural Racism;success;Surveys;System;Testing;Therapeutic;treatment as usual;United States Agency for Healthcare Research and Quality;virtual;Waiting Lists

PROJECT_TITLE: Educational-Clinical Linkage to Improve Health Equity for Children with Developmental Delays and Disabilities from Marginalized Communities


PI_NAMEs: EZENWA, MIRIAM OMELEBELE (contact)

PROJECT_TITLE: Planning and Evaluation Core


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative  This proposal will benefit both basic scientists in their understanding of the drug resistant brain cancer – glioblastoma – as well as chemical biologists in deriving new selenium-containing small molecules. This proposal is also directly related to the NCI’s mission statement to “help all people live longer, healthier lives” as the project uses a neuroprotective agent to treat drug resistant glioblastoma which should both extend lifespan while also decreasing toxic side effects. In this way, I believe this project will both increase our knowledge and ability to target drug resistant brain tumors in a smarter way.

PI_NAMEs: TIEK, DEANNA MARIE (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Active Sites;Advisory Committees;Affect;analog;Animal Model;Animals;Automobile Driving;Biological;Biology;Blood - brain barrier anatomy;Brain;Brain Neoplasms;cancer drug resistance;cancer type;candidate identification;Caring;Cell Death;Cell Line;cell type;Cells;Chemicals;chemotherapeutic agent;Clinical;Coin;CRISPR screen;Cyst;Cysteine;Cystine;Data;Dependence;design;Disease;Disease Resistance;DNA;DNA Damage;Drops;Drug resistance;Drug Targeting;ebselen;Electron Microscopy;Environment;Enzymes;Evaluation;EWSR1 gene;extend lifespan;frontier;Future;genome sequencing;Glioblastoma;Glioma;Goals;Hypoxia;Image;Immunocompetent;improved;In Vitro;in vivo;insight;Intervention;Iron;Knowledge;Learning;lipidomics;Lipids;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Mentors;Metabolic;Methods;Microscopy;Mission;Mitochondria;model design;Modeling;Monitor;Mutation;neuroprotection;Neuroprotective Agents;Newly Diagnosed;novel;Outcome;oxidation;Oxidative Stress;Pathway interactions;patient screening;Patients;Persons;Phenotype;Postdoctoral Fellow;potential biomarker;Proteins;Proteomics;Recycling;Research;Resistance;Resources;response;RNA;RNA Splicing;Role;Running;Scientist;Selenium;Selenium Compounds;side effect;skills;small molecule;standard of care;Structure;Sulfur;Techniques;temozolomide;Testing;Therapeutic Effect;Therapeutically Targetable;Training;tumor xenograft;Universities;Validation;whole genome;Work

PROJECT_TITLE: Ferroptosis in drug resistant glioma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


PI_NAMEs: ALLEN, JOHN M (contact)

PROJECT_TITLE: Research Education Core