ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation;Stroke

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND STATE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Patients who have experienced a stroke or other brain injury frequently experience word finding problems - a condition that can affect daily activities, psychological well-being, and overall quality of life of those with the condition and their families. One major challenge in this area is the lack of efficient and precise metrics to support treatment research and clinical decision making. The primary goal of this project is to utilize novel computational tools to develop a computer adaptive assessment system that will reach high levels of precision while minimizing testing burden for both patients and clinicians, and will ultimately allow each task during a clinical session to be administered dynamically and tailored uniquely to each patient.

PI_NAMEs: FERGADIOTIS, GERASIMOS  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Adopted;Affect;Age;American;Anomia;Aphasia;Aphasiology;Apraxia;archived data;Area;Bayesian Modeling;Brain Injuries;Calibration;Clinical;Clinical Data;clinical decision support;clinical decision-making;clinical diagnostics;clinical encounter;Cognitive;Communication;computer science;Computer software;computerized tools;Computers;cost;Data;design;Development;Diagnostic;diagnostic platform;Disease;Exhibits;experience;Family;Frequencies;Goals;Hand;Hand functions;High-dimensional Modeling;in silico;Investigation;Joints;Length;Linguistics;Measurement;Measures;Modeling;Names;National Institute on Deafness and Other Communication Disorders;Normal Statistical Distribution;novel;Participant;Patients;Performance;Persons;Philadelphia;post stroke;predictive modeling;Process;processing speed;Property;Proxy;Psycholinguistics;Psychometrics;Quality of life;Reaction Time;Research;Research Personnel;Residual state;response;Rest;Retrieval;Sampling;Series;Severities;Source;Speech;Speed;Statistical Models;statistics;Strategic Planning;Stroke;System;tau Proteins;Techniques;Testing;theories;treatment research;Variant;Well in self

PROJECT_TITLE: Integrating response time and ancillary information into the assessment of anomia

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Charcot-Marie-Tooth Disease;Clinical Research;Genetics;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Rare Diseases

ORG_CITY: DALLAS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Two infants were identified with an immune deficiency, growth delay, Marie-Charcot Tooth disease and a diminished ability to sweat. DNA sequencing uncovered a mutation in a gene called the inositol triphosphate receptor type 3. A mouse model was developed to understand how this mutation affects the immune, nervous, and secretory systems, with the goal of developing therapies to improve the clinical problems for people with these type of gene mutations.

PI_NAMEs: VAN OERS, NICOLAI STANISLAS CYRILLE (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Adaptive Immune System;Affect;Alleles;Amino Acid Substitution;Anhidrosis;Antigens;autosome;B-Cell Antigen Receptor;B-Lymphocytes;Benign;Binding;Biological Assay;Body System;Calcium;Calcium Channel;Cell Death;Cell Differentiation process;cell type;Cells;Cessation of life;Charcot-Marie-Tooth Disease;Child;Clinical;ClinVar;Code;Complex;controlled release;CRISPR/Cas technology;Databases;Defect;DNA sequencing;Dominant-Negative Mutation;eccrine;Eccrine Glands;Endoplasmic Reticulum;Family member;G-Protein-Coupled Receptors;Gene Mutation;Genes;genome sequencing;Goals;Growth;Growth Factor;Heterozygote;Homo;Human;Immune;Immune system;Immunity;immunodeficiency;improved;Individual;Infant;inorganic phosphate;Inositol;Intervention;ITPR1 gene;knock-down;Knock-in Mouse;Ligands;Missense Mutation;Modern Medicine;Molecular Conformation;mouse model;Mus;Muscle Weakness;Mutation;Neurons;novel;novel therapeutic intervention;Patients;Peripheral Nervous System;Peripheral Nervous System Diseases;Persons;Process;Proliferating;receptor;Receptor Signaling;release of sequestered calcium ion into cytoplasm;Reporting;response;Schwann Cells;Second Messenger Systems;Signal Transduction;small hairpin RNA;Sweating;Syndrome;System;T-Lymphocyte;Technology;therapeutic target;therapy development;tripolyphosphate;Variant

PROJECT_TITLE: The impact of ITPR3 mutations on immunity

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Reducing Inequities by Promoting Participatory Learning Experiences in Science (RIPPLES) addresses NIH-identified needs for professional learning opportunities for secondary science teachers, classroom curriculum that addresses fundamental topics in life science, and strategies to help engage youth—particularly those from underserved populations—in biomedical research and public health. RIPPLES harnesses the topic of health disparities to teach science concepts, highlight the many factors that influence health outcomes, and help students learn about careers in biomedical research and community health. It aims to build understanding of the mechanisms of health disparities to inspire and empower secondary students to work towards healthy futures for all.

PI_NAMEs: CHOWNING, JEANNE TING (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: Address;Age;Alaska Native;American Indians;anti-cancer research;Award;Biological;Biological Sciences;Biology;Biomedical Research;Bone Marrow Transplantation;Cancer Center;career;Cessation of life;clinical care;Communities;Community Actions;Community Health;community partnership;comparison group;Complex;curriculum development;Data;data resource;design;Development;Dimensions;Disease;Educational Curriculum;Educational process of instructing;Educational workshop;efficacy evaluation;empowerment;Equity;Ethics;Event;Evolution;experience;flexibility;follow-up;Fostering;Funding;Future;Goals;Health;Health Disparities Research;health disparity;Health education;health equity;Health Promotion;high school;High School Student;Human;Immunotherapy;Indigenous;Inequity;interest;International;junior high school;Justice;Learning;learning materials;lens;Malignant Neoplasms;member;Mentors;Mutation;native youth;next generation;Next Generation Science Standards;Outcome;Participant;peer;peer coaching;Program Development;programs;Public Health;Research;Resources;Schools;Science;science education;science teacher;Science, Technology, Engineering and Mathematics;Scientist;Secondary Schools;skills;social;social determinants;Social Environment;structural health determinants;student participation;Students;summer program;teacher;Teacher Professional Development;Underrepresented Populations;Underrepresented Students;Underserved Population;United States National Institutes of Health;Variant;Washington;Work;Youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (55)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The goal of this project is to create AI4Health, the first game-based learning environment to introduce students to AI in the context of biomedical careers. AI4Health is designed to promote the interest of diverse adolescents in biomedical careers through leveraging significant advances in game-based learning technologies to create engaging interactions that enable them to virtually explore biomedical careers and learn how AI can be used to solve health science problems. The project will investigate the impact of AI4Health on diverse middle school students’ knowledge of biomedical research and health science careers featuring AI, their interest in biomedical research and health science careers featuring AI, and their self-efficacy for pursuing biomedical and health science careers featuring AI.

PI_NAMEs: OZER, ELIZABETH M (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Adolescence;Adolescent;Adolescent Development;adolescent health;Adolescent Medicine;Artificial Intelligence;behavior change;Behavioral Research;Biomedical Research;California;career;Clinical Research;Collaborations;Creativeness;design;Developing Countries;Development;Education;educational atmosphere;Equity;Ethnic Origin;experience;Faculty;Foundations;Game Based Learning;game development;Gender;girls;Goals;Health;Health Personnel;Health Sciences;Imagination;Informatics;innovative technologies;Interdisciplinary Study;interest;Intervention;Interview;junior high school;K-12 student;Knowledge;Learning;learning engagement;Machine Learning;Middle School Student;next generation;North Carolina;outreach;Pathway interactions;Pediatrics;Phase;Play;Preventive;Primary Care;professor;Race;Recording of previous events;Research;Research Personnel;Research Support;Resources;Role;San Francisco;Science;science teacher;Science, Technology, Engineering and Mathematics Education;Self Efficacy;Series;Students;Talents;teacher;Technology;Testing;Underrepresented Populations;Universities;virtual;web site;Woman

PROJECT_TITLE: AI4Health: Engaging Adolescents in Artificial Intelligence to Promote Pathways to Biomedical Careers


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Candida auris is an emerging fungal pathogen responsible for healthcare-associated and fomite transmissible outbreaks worldwide. This project will investigate the genetic circuitry facilitating the ability of C. auris to attach to abiotic surfaces, the predicating first step of colonization and persistence. These studies are essential for understanding the molecular mechanisms critical to C. auris transmission, which will be required for the development of targeted interventions against disease spread.

PI_NAMEs: SANTANA, DARIAN JAY (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Address;Adhesions;Adhesives;anti-fungal agents;Automobile Driving;Bacterial Adhesins;burden of illness;Candida albicans;Candida auris;Case Study;Cell surface;cell type;Cell-Matrix Junction;Cells;Chromatin;Chromatin Remodeling Factor;Clinical;Collection;Data Set;Decontamination;design;Development;differential expression;Disease;Disease Outbreaks;Disinfectants;Excision;Family;Foundations;fungus;Gene Family;Genes;Genetic;Genetic Transcription;genetic variant;Genome;genome wide association study;Genomics;Goals;Healthcare;Homologous Gene;Hospitals;Hydrophobic Surfaces;Implant;Incidence;Individual;Infection;Infection Control;Infection prevention;Intervention;Knowledge;Link;Measures;Mediating;Medical Device;member;Microbial Biofilms;Molecular;molecular scale;Multi-Drug Resistance;mutant;novel;Outcome;overexpression;pathogenic fungus;Patients;Phenotype;Population;Predisposition;prevention practice;Process;Proteins;Protocols documentation;Regulation;Research;Resistance;resistant strain;Structure;Surface;Testing;transcription factor;Transcriptional Regulation;transcriptomics;transmission process;Variant;Virulence

PROJECT_TITLE: Molecular Mechanisms of Candida auris Adhesion to Abiotic Surfaces

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07A-F(20)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative Antimicrobial peptides have been used to circumvent the evasion of microbial infection; additionally, they play a critical role in drug delivery. However, limitations such as proteolytic degradation, nonspecific distribution, and reduced efficacy and specificity have overshadowed their benefits to some extent. The ability to design and test a delivery system capable of evading these issues enhances the utilization of antimicrobial peptides.

PI_NAMEs: TACKIE-YARBOI, ETHEL NAA ODEY (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Address;alpha helix;Amino Acids;anti-cancer;anti-cancer therapeutic;anti-microbial peptide;antimicrobial;aqueous;Bacterial Infections;Bee Venoms;Binding;Biological Assay;biophysical analysis;biophysical techniques;Calorimetry;cancer biomarkers;CASP3 gene;Cell Line;Cell membrane;Cells;Cellular Assay;Cellular Membrane;Charge;Circular Dichroism;Coupling;Cytolysis;cytotoxic;cytotoxicity;Cytotoxin;Derivation procedure;design;Diagnostic;Discrimination;Disease;Drug Delivery Systems;drug market;Erythrocytes;expectation;Extravasation;fibroblast-activating factor;Fluorescence;Future;High Pressure Liquid Chromatography;improved;In Situ;In Vitro;Incubated;Infection;Investments;Kinetics;Label;Link;Literature;Location;Malignant Neoplasms;Mammalian Cell;Masks;Membrane;Metabolic;Methods;microbial;Molecular Conformation;Monitor;Nerve Degeneration;overexpression;Parents;Penetration;peptide drug;peptide hormone;Peptide Hydrolases;Peptides;Pharmaceutical Preparations;physical property;Play;prevent;Prodrugs;Property;Proteins;Proteolysis;prototype;Research;response;Role;Serum;Side;side effect;skills;small molecule;Solid Neoplasm;Specificity;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Structure;System;Techniques;Testing;Therapeutic;Toxin;Training;tumor;unilamellar vesicle;Vesicle;Whole Blood;WI 38 cell

PROJECT_TITLE: Dual protease activated peptides for specific targeting


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative  The enteric nervous system (ENS) is responsible for critical functions of the gut such as peristalsis, waste elimination, and nutrient absorption. The sacral neural crest contributes to the post-umbilical ENS and disruption of this innervation can result in life threatening developmental diseases. Further study of the sacral neural crest’s development will provide better insight into this vital developmental population and will build a foundation for better therapeutic treatment of diseases of the ENS.

PI_NAMEs: JACOBS-LI, JESSICA  (contact)

PROGRAM_OFFICER_NAME: KOSTER, MARANKE IRENE

PROJECT_TERMS: Address;Birds;Brain;Cell Lineage;Cells;Chick;Chimera organism;Colon;Communication;comparative;Congenital Disorders;Congenital Megacolon;craniofacial;Development;developmental disease;Disadvantaged;Disease;Distal;Enteric Nervous System;Epithelium;Etiology;experimental study;Fluorescence-Activated Cell Sorting;Foundations;gastrointestinal;Gene Expression Profile;Gene Expression Profiling;gene regulatory network;Genes;genetic signature;Genetic Transcription;Genus Alpharetrovirus;Immune response;Infection;infection risk;insight;Knowledge;Label;Life;loss of function;Mediating;melanocyte;Methods;Modernization;Molecular Biology Techniques;Morphologic artifacts;Myenteric Plexus;nerve supply;Nervous System;nervous system development;Neural Crest;Neural Crest Cell;Neural Tube Closure;Neuroglia;Neuronal Differentiation;Neurons;novel;nutrient absorption;Obstruction;Operative Surgical Procedures;Peripheral Nervous System;Peristalsis;Population;Proliferating;Quail;Regulation;repaired;Research;retroviral-mediated;Role;Scheme;Seminal;single-cell RNA sequencing;Skeleton;Skin;stem;stem cell population;Structure;Submucous Plexus;Techniques;Therapeutic;Time;trauma surgery;Umbilicus;Visualization;wasting;Work

PROJECT_TITLE: Lineage and transcriptional analysis of sacral neural crest contribution to the enteric nervous system


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Complementary and Integrative Health;Mental Health;Pain Research;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Non-pharmacological cognitive behavioral interventions for chronic pain (CP), which seek to maximize physical, social, and occupational functioning, are increasingly relied upon for the overwhelming number of individuals suffering with this condition. Much CP research is limited by the use of between-subject designs and self-report measures that lack ecological validity and may be subject to bias. The proposed research will use an objective indicator of physical function (actigraphy), real-time, real-world measures of pain (i.e., ecological momentary assessment), latent growth curve modelling, and qualitative methods to address limitations in the understanding and conceptualization of functional improvement in CP, and thus will advance public health goals of improving and refining relevant complementary and integrative interventions for CP.

PI_NAMEs: TYNAN, MARA  (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: Accelerometer;actigraphy;Address;Attenuated;Automobile Driving;Behavior;Belief;biopsychosocial;chronic pain;chronic pain management;Clinical;Cognitive Therapy;Collection;Complementary therapies;cost;Data;Data Collection;design;Disabling;Ecological momentary assessment;Equation;experience;Fellowship;follow-up;functional improvement;functional outcomes;General Population;Goals;Growth;Health;health goals;improved;improved outcome;Individual;innovation;Integrative Therapy;Intervention;intervention effect;Interview;Knowledge;Life;Life Expectancy;Literature;Measures;member;Mental Health;Mentorship;Methods;Modeling;National Center for Complementary and Integrative Health;novel;Occupational;Opioid;Outcome;Outcome Measure;Pain;Pain interference;Pain management;Pain Measurement;Pain Research;Parents;Participant;Patient Self-Report;Pattern;Persons;Physical activity;Physical Function;Population;post intervention;Public Health;Qualitative Methods;Questionnaires;Randomized;Randomized, Controlled Trials;Recontacts;Research;Research Personnel;restoration;Risk;secondary analysis;skills;social;social relationships;Statistical Data Interpretation;suicidal risk;Technology;Therapeutic Intervention;Thinking;Time;tool;Training;Veterans;Walking;Work

PROJECT_TITLE: Characterizing the relationship between objective physical activity and momentary pain in cognitive behavioral interventions for chronic pain


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: JEFFERSON CITY

ORG_NAME: MISSOURI STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: MO

PHR: Project Narrative Maintenance of Missouri’s Conformance with the Animal Feed Program Standards (AFRPS) and Coordinating Missouri’s Preventive Control Activities (U18) PAR-20-132 of the Missouri Department of Agriculture will assist the FDA in providing feed/food safety not only for Missouri but other states, as Missouri provides a significant percentage of the nation’s livestock and pet food production. The regulation of feed is vital for the protection of livestock feed and pet food consumers and producers, as feed is an important link to the human food supply and therefore an important element of public health.

PI_NAMEs: KOESTNER, MARY  (contact)

PROGRAM_OFFICER_NAME: BHATTACHARYYA, SOMA

PROJECT_TITLE: Maintenance of the Animal Feed Regulatory Program Standards (AFRPS) and the Development of Preventive Control Inspection Infrastructure by the Missouri Department of Agriculture, Bureau of Feed, Seed.


ADMINISTERING_IC: MH

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative Healthy relationships are a cornerstone of the human experience and benefit our physical and emotional wellbeing. To be successful and achieve shared goals, partners must organize their behavior via reciprocal action, but the vast majority of studies on pair bonding study only one member of a pair. Here, I will use pair bonding prairie voles to examine both bonded partners at the behavioral and neuromolecular levels, which will uncover how pairs organize their behavior to enable the emergent properties of relationships.

PI_NAMEs: BRUSMAN, LIZA EDEN (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Address;affiliative behavior;Animals;Back;Behavior;Behavioral;behavioral study;Bioinformatics;Biological;Brain;Brain region;career;cell type;Cells;complex data;Computational Technique;Computer Analysis;Data;Data Set;dyadic interaction;Elements;Emotional;Exhibits;experience;Experimental Designs;experimental study;Feedback;Gene Expression;Gene Expression Profile;Genetic Transcription;Goals;Grain;Health;Human;Individual;Knowledge;lens;Machine Learning;machine learning algorithm;machine learning pipeline;Maps;Medial;member;Modeling;Molecular Biology;Nature;neural;Neurobiology;Neuroglia;Neurons;Neurosciences;Nucleus Accumbens;Organizational Objectives;Outcome;Oxytocin;Oxytocin Receptor;Pair Bond;Pattern;Personal Satisfaction;Persons;Play;Population;Poverty;prairie vole;preference;Prefrontal Cortex;Process;Property;Research Personnel;Resolution;Role;Shapes;single nucleus RNA-sequencing;skills;social;Social Behavior;Social Interaction;Structure;success;Techniques;Testing;Time;Tissues;Training;transcriptome sequencing;transcriptomics;Well in self;Work

PROJECT_TITLE: Emergent behavioral and transcriptional properties of pair bonds


ORG_CITY: CHARLESTON

ORG_NAME: WEST VIRGINIA STATE DEPT OF AGRICULTURE

ORG_STATE: WV

PHR: Project Narrative The focus of this project is to improve the West Virginia Department of Agriculture (WVDA), Regulatory and Environmental Affairs Division (READ) feed regulatory program by maintaining implementation of the Animal Feed Regulatory Program Standards (AFRPS). AFRPS provides a framework for improving state animal feed regulatory programs and promotes a consistent methodology to animal feed regulation across jurisdictions. Continuing to implement AFRPS will enhance the protection of the animal feed supply, support principles of an integrated food safety system, and protect public health.

PI_NAMEs: LINTON, CHADWICK S (contact)

PROGRAM_OFFICER_NAME: CLARK, JACOB

PROJECT_TITLE: WVDA AFRPS 2020


ORG_CITY: LANSING

ORG_NAME: MICHIGAN STATE DEPT OF AGRICULTURE

PHR: If chosen to participate in the AFRPS Maintenance Track Cooperative Agreement the Michigan Department of Agriculture and Rural Development (MDARD) Animal Feed Program (AFP) will continue to build, improve, and maintain the eleven standards. This will include:  • Reviewing the Regulatory Foundation Worksheet, Standard 1  • Revising the Field Competencies Recordkeeping Form, continue training two  new field inspectors, and maintain CE training records for staff, Standard 2  • Continue to improve inventory data to focus resources on high risk firms and  products, Standard 3  • Maintain auditing as required by Standard 4  • Continue to refine and enhance our investigation, recall, and consumer  complaint procedures, Standard 5  • Review and evaluate our enforcement strategy, Standard 6  • Develop new and innovative ways to provide information to our stakeholders,  Standard 7  • Review and improve the AFP Workplan by utilizing historical numbers to better  calculate the number of FTE’s required in the program. Reevaluate the  Implementation of AFRPS, Standard 8  • Maintain the AFP Improvement Plan, Standard 9  • Continue to plan and evaluate the AFP Sampling Plan, this includes reviewing  how the AFP interprets the results and how the program handles enforcement,  Standard 10 and 11

PI_NAMEs: ANDRICH, CARRIE L. (contact)

PROJECT_TITLE: AFRPS Maintenance


ORG_CITY: CAMBRIDGE

ORG_DEPT: CHEMISTRY

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative The proposed research is aimed toward the development of ortho-dithioquinones as pseudometal organocatalysts, entirely metal-free small molecules capable of mimicking the redox processes and elementary steps of traditional transition-metal catalysts. The proposed strategy will not only provide a suite of organocatalysts to serve as complements and alternatives to transition-metal catalysts, but also it will provide new opportunities for the discovery of fundamental new reactivity in bond forming processes and for the development of novel methodologies capable of unlocking previously dormant catalytic pathways. Ultimately, this research will facilitate the expansion of sustainable and economical organocatalytic reactions as alternatives to traditional transition-metal catalysis, thereby enhancing the productivity of medicinal chemistry campaigns, increasing accessibility in pharmaceutical development and proliferation, and advancing fundamental aspirations in the pursuit of human health.

PI_NAMEs: LEIBLER, ISABELLE  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Address;adduct;Architecture;aspirate;Behavior;Catalysis;catalyst;Chemicals;Chemistry;Collection;Communities;Complement;Complex;Computer Models;Conflict (Psychology);cost;Coupling;covalent bond;COVID-19 pandemic;Creativeness;Dependence;Deposition;Derivation procedure;design;Development;drug discovery;Drug Screening;drug synthesis;Electronics;Elements;Engineering;Ensure;Environment;Excision;Extinction;Face;Free Energy;Future;Goals;Guidelines;Health;Heart;Human;In Situ;invention;Investigation;Kinetics;Knowledge;Libraries;Ligand Binding;Ligation;manufacture;Medical Research;Metals;Methodology;Modality;Modern Medicine;Modernization;Molecular;National Institute of General Medical Sciences;Natural Products;Nature;novel;Organic Synthesis;Oxidation-Reduction;Pathway interactions;Periodicals;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Play;Preparation;preservation;Procedures;Process;Productivity;Proliferating;Property;Quinones;rational design;Reaction;Reagent;Regulation;Research;Route;scaffold;Series;small molecule;Societies;Source;Spectrum Analysis;Structure;Structure-Activity Relationship;Sulfur;supply chain;Synthesis Chemistry;Techniques;Theoretical Studies;Therapeutic;Toxic effect;Transition Elements;wasting;X-Ray Crystallography

PROJECT_TITLE: New eras of catalysis: Towards the development of pseudotransition metal organocatalysts for metal-free cross-coupling transformations


ORG_CITY: COLUMBIA

ORG_NAME: SC STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: SC

PHR: Project Narrative The South Carolina Department of Agriculture (SCDA) has achieved full implementation of all eleven of the Animal Feed Regulatory Program Standards (AFRPS) as determined by its audit in November 2021. Through this cooperative agreement, SCDA will continue to use systematic methods to maintain these achievements along with identifying and overcoming obstacles to full conformance and incorporating more Preventative Control Inspections. The South Carolina Feed Safety Program will continue to enhance its efforts towards the regulation of animal feed safety. 1

PI_NAMEs: DORTON, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: LITTRELL, KEITH

PROJECT_TITLE: Maintenance of the Animal Feed Regulatory Program Standards with Coordinated Preventive Control Regulatory Activities and Capacity Building in South Carolina


ORG_CITY: OLYMPIA

ORG_NAME: WA STATE DEPARTMENT OF AGRICULTURE

PHR: PAR-20-132: Washington State Department of Agriculture (WSDA) - Animal Feed Program Maintenance of Animal Feed Regulatory Program Standards and Implementation of Preventive Controls Regulatory Activities and Capacity PROJECT NARRATIVE The Washington Department of Agriculture PAR-20-132 project intention is to maintain and improve our program with the Animal Feed Regulatory Program Standards (AFRPS) and to expand our ability to implement the Preventive Controls for Animal Food (PCAF) Rule. Overall, our goal aligns with PCAF Rule to advance efforts for a nationally integrated food safety system by encouraging the safe manufacturing and processing of animal food and promoting understanding and compliance with the requirements of the PCAF Rule. This proposal explains how we will ensure AFRPS is sustained and increase the number of staff to meet the needs for all project deliverables, including for training and auditing. We also included in our proposal to assist the feed industry, particularly small and very small feed businesses through outreach to enhance and improve their understanding of the PCAF requirements and support them to successfully develop PCAF compliant animal food safety during manufacturing, packing, handling and holding of their animal food products as well as their monitoring systems.

PI_NAMEs: FERGUSON, ASHLEE-ROSE  (contact)

PROGRAM_OFFICER_NAME: ISAKSON, ISAIAH


ORG_CITY: NASHVILLE

ORG_NAME: TN STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: TN

PHR: Animal Feed and PC Project Narrative In April 2019, the Tennessee Department of Agriculture (TDA) achieved full implementation and conformance to the 2019 AFRPS. Moving forward, continued funding support is requested to assist TDA in maintaining full conformance with the AFRPS as well as delivering a robust PC inspection program. This funding will ensure TDA has the resources and infrastructure necessary to sustain and enhance the State’s animal feed regulatory activities aimed at reducing hazards in firms that manufacture, process, pack, or hold animal food.

PI_NAMEs: POWELL, MARK  (contact)

PROJECT_TITLE: Enhance Tennessee's Animal Feed Regulatory Program in Support of an Integrated Food Safety System


ORG_CITY: RALEIGH

ORG_NAME: NC STATE DEPT OF AGRI AND CONSUMER SERV

ORG_STATE: NC

PHR: Project Narrative Access to a supply of safe animal foods and feed ingredients is one the most crucial elements for ensuring the world’s population a safe human food supply. Utilizing the Animal Food Regulatory Program Standards, the North Carolina Food & Drug Protection Division will further develop the capabilities of their Animal Feed Regulatory Program to conduct comprehensive animal food safety inspections. under the scope of 21 CFR Part 507. We will strive to improve the safety and security of the US animal food supply and improve the protection of both human and animal health through this commitment to implement an inspection and enforcement program in partnership with FDA and other state regulatory programs.

PI_NAMEs: POWELL, MICHELLE  (contact)

PROJECT_TITLE: Continued development of a risk-based Animal Feed Inspection Program within the NCDA&CS through continuous implementation of uniform policies that ensure Feed Safety and promote Compliance with FSMA


ORG_CITY: LINCOLN

ORG_NAME: NEBRASKA ST DEPARTMENT OF AGRICULTURE

ORG_STATE: NE

PHR: Project Narrative for PAR-20-132: Development and Maintenance of the Animal Feed Regulatory Program Standards with Optional Coordinated Preventive Control Regulatory Activities and Capacity Building (U18) Clinical Trial Not Allowed. The Nebraska Department of Agriculture (NDA) is prepared to begin the Maintenance phase of AFRPS and the Preventive Controls Initiative. NDA has found that AFRPS has been of tremendous benefit, helping the program become more efficient and aiding in our mission of safeguarding human food and animal health by ensuring feed is safe, unadulterated, and honestly prepared. We anticipate the PC Initiative will continue that mission, allowing NDA to help feed firms ensure they are adhering to the rules set forth in 21 CFR 507, through outreach and education opportunities.

PI_NAMEs: HUBENKA, CHARLES  (contact)

PROJECT_TITLE: NEBRASKA'S MAINTENANCE OF THE ANIMAL FEED REGULATORY PROGRAM STANDARDS WITH PREVENTIVE CONTROL REGULATORY ACTIVITIES AND CAPACITY BUILDING


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Proposal Title: Multifactorial dynamic modeling of brain asymmetry in neurodevelopmental disorders FOA: PA-21-219 Joint NINDS/NIMH Exploratory Neuroscience Research Grant (R21 Clinical Trial Optional) Project Narrative This project is proposed to characterize the dynamic causal relationships between brain asymmetry, genetic and environmental risk factors as well as psychopathological behaviors for neurodevelopmental disorders in typically and atypically developed children and adolescents. The proposed research is relevant to public health because it seeks to reveal the neurobiological pathways through which the pathological brain structural abnormalities and clinical symptoms of neurodevelopmental disorders arise, and to elucidate etiological distinctions and overlaps between different neurodevelopmental disorders. Upon completion, our study will provide novel models and tools for assisting diagnosis and treatment selection for heterogeneous childhood mental disorders as well as the development of precision medicine approaches.

PI_NAMEs: ZHAO, LU  (contact)

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: Address;Adolescent;Affect;Algorithms;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Behavior Disorders;behavior measurement;Behavioral;Biological;Biological Markers;Biological Process;Biology;Brain;brain abnormalities;brain dysfunction;Brain imaging;Brain region;case control;Categories;causal model;Child;Child Behavior;Childhood;Classification;Clinical;Clinical assessments;Clinical Trials;Cognition;Cognitive;cognitive development;cognitive testing;cohort;Complex;Cross-Sectional Studies;Data;Data Set;data space;demographics;design;Development;developmental disease;Diagnosis;Diagnostic;diagnostic strategy;disability;Disease;dynamic system;Elements;endophenotype;Environment;Environmental Risk Factor;Etiology;Functional impairment;Genes;Genetic;genetic risk factor;Goals;gray matter;Health;Heterogeneity;imaging biomarker;imaging study;improved;Individual;Intellectual functioning disability;Intervention;Joints;Language;large datasets;Learning;Life Style;longitudinal dataset;machine learning method;Measurement;Mediating;Medical Records;Memory;Mental disorders;Mental Health;Methods;Modeling;Morphology;Motor;multimodal data;multimodality;multiple omics;myelination;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;Neuroanatomy;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;Neurosciences Research;novel;Participant;Pathologic;Pathway interactions;Pattern;Persons;Phenotype;physical conditioning;Population;precision medicine;predictive marker;Process;Proxy;Psychopathology;psychosocial;Public Health;Research;Research Design;Research Project Grants;Risk Factors;Schizophrenia;Selection for Treatments;Societies;sociodemographics;spatiotemporal;Specificity;Structural defect;Subgroup;Symptoms;synaptic pruning;System;Time;tool;Torque;trait;United States;unsupervised clustering;white matter;Youth

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Through regular epidemics and infrequent pandemics, influenza A virus causes mild to severe disease in a significant proportion of the population every year. By defining the mechanisms by which influenza A viruses evolve, our research supports efforts to control the spread of influenza viruses in the human population and the emergence of novel influenza A viruses from non-human reservoirs.

PI_NAMEs: KOELLE, KATHARINA V;LOWEN, ANICE C (contact);PEREZ, DANIEL R

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Bar Codes;Cell Culture System;Cell Culture Techniques;Cells;Characteristics;Collection;Complement;Coupled;Data;design;Disease;Distant;driving force;Effectiveness;Environment;Epidemic;Epidemiology;Event;Evolution;experimental study;Ferrets;fitness;Founder Effect;Frequencies;Genetic Drift;genetic evolution;Genetic Polymorphism;Genetic Recombination;genetic selection;Genetic Variation;Genome;Heterogeneity;Human;Immune response;Immunity;Influenza A virus;Influenza A Virus, H3N2 Subtype;influenzavirus;insight;Maintenance;Mathematics;Measures;Modeling;models and simulation;Molecular;Molecular Virology;Mutation;Natural Selections;Nature;next generation sequencing;novel;NP protein;Nucleotides;Panama;pandemic disease;pathogenic virus;Pattern;permissiveness;Phenotype;Population;Population Biology;Population Dynamics;Population Heterogeneity;predictive modeling;Property;Public Health;Research;Research Support;RNA Viruses;Role;Seasons;Shapes;Site;Stochastic Processes;Structure;System;systems research;Testing;theories;tool;Variant;Viral;Virion;Virus;Virus Diseases;virus genetics;Visualization;Work;zoonotic spillover

PROJECT_TITLE: Role of spatial structure in shaping viral population diversity and evolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Y(02)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Influenza;Pneumonia and Influenza;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Vaccine Related

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Diverse populations of memory T cells circulate throughout the body and protect us from re-infection by previously encountered pathogens, but our understanding of how these populations develop, compete, and are maintained is incomplete. A quantitative grasp of this complex ecosystem will reveal what determines the duration of T cell memory, and how to manipulate it; for example, to extend the protection given by vaccines, or to boost and sustain the activity of tumor-specific T cells. In this project we will integrate mathematical modeling and new experimental tools to quantify multiple aspects of circulating T cell dynamics in depth.

PI_NAMEs: YATES, ANDREW  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Activities of Daily Living;Age;Antigens;Biological Assay;Birth;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell division;Cells;Characteristics;chronic infection;Clone Cells;Complex;COVID-19 pandemic;cross immunity;cross reactivity;Data;Development;DNA;Ecosystem;Environment;Event;experimental study;Exposure to;Generations;grasp;Homeostasis;Human;Immune response;Immune system;Immunity;Immunologic Memory;immunopathology;Infection;Influenza;influenza infection;influenzavirus;Kinetics;Knowledge;Label;Life;life history;Link;Lymphocyte Subset;Malignant Neoplasms;Maps;mathematical model;Mediating;Memory;memory CD4 T lymphocyte;memory encoding;Methods;Modeling;Mouse Strains;Mus;novel;pathogen;Pathway interactions;Pattern;Phenotype;Population;Population Heterogeneity;Proliferating;Recording of previous events;recruit;Regulatory T-Lymphocyte;Reporter;response;Role;self-renewal;Structure;success;Supplementation;Survival Analysis;System;T cell regulation;T cell response;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;therapy development;Time;tool;trafficking;tumor;Uncertainty;Vaccine Design;Vaccines

PROJECT_TITLE: Modeling the development, structure and regulation of T cell memory

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BOSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Lung cancer screening by chest CT can detect lung cancer earlier and make the disease less deadly; but even among nodules that are intermediate risk, a small minority are cancerous. We will develop and validate innovative biomarkers from nasal swabs, blood, and advanced imaging analysis for determining which intermediate risk lung nodules detected via screening, or detected incidentally as part of routine clinical care, are actually lung cancers to speed treatment while minimizing invasive tests and clinical uncertainty related to benign nodules. We will partner with two molecular diagnostics companies to refine and standardize these biomarkers so that useful biomarkers can quickly be put to use.

PI_NAMEs: BEANE, JENNIFER ELLEN;DUBINETT, STEVEN M.;HSU, WILLIAM ;LENBURG, MARC ELLIOTT (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Adoption;Artificial Intelligence;Benign;Bioinformatics;Biological Assay;Biological Markers;Biological Sciences;biomarker discovery;Biometry;Blood;Boston;Bronchoscopy;cancer biomarkers;Cancer Detection;Cancer Etiology;Cancer Research Project;cancer risk;Cancerous;Cells;Cessation of life;chest computed tomography;Classification;Clinical;clinical application;clinical assay development;clinical care;clinical epidemiology;Clinical Research;Collection;commercial launch;Complex;computed tomography screening;Consensus;cost;Data;deep learning;Detection;Diagnostic;Diagnostic Procedure;Diagnostic tests;Diameter;Disease;Early Detection Research Network;Ensure;Evolution;Excision;follow-up;Funding;Gene Expression;Gene Expression Profile;Genetic Markers;Genomics;Goals;high risk population;Image;imaging biomarker;Immunologic Markers;improved;Incidental Findings;Individual;Inferior nasal concha;Infrastructure;innovation;Laboratories;Localized Disease;low dose computed tomography;Lung;lung cancer screening;Lung nodule;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Measures;Medical center;Medicare;minimally invasive;Minority;Modality;Modeling;molecular diagnostics;molecular marker;mortality;multidisciplinary;Names;Nasal Epithelium;nasal swab;Neoplasm Circulating Cells;Nested Case-Control Study;Nodule;Nose;novel;Office Visits;oncology program;Operative Surgical Procedures;Pathology;patient population;Patients;Performance;performance tests;Peripheral Blood Mononuclear Cell;Population;Population Heterogeneity;precision oncology;Predictive Value;prevent;programs;prospective;Protocols documentation;Pulmonology;radiomics;Reproducibility;Research Design;Risk;Sampling;screening;screening program;Solid;Speed;Standardization;Swab;Testing;Time;Tissue Sample;Training;Uncertainty;Universities;Work;X-Ray Computed Tomography

PROJECT_TITLE: The Boston University - UCLA Lung Cancer Biomarker Characterization Center


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: NEUROSURGERY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Narrative (public health relevance statement): The grim prognosis and lack of therapeutic options for pediatric high-grade gliomas highlight the urgency of working towards developing novel treatment modalities. In this application, using a genetically-engineered immunocompetent model of pHGG subtypes and patient samples, we will have a unique opportunity define inter- and intra-tumor TME heterogeneity and to test the role of TME in pHGG tumor progression.

PI_NAMEs: BECHER, OREN JOSH;HAMBARDZUMYAN, DOLORES  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Address;Adult;Affect;Anatomy;Antineoplastic Agents;Automobile Driving;Biological Assay;Blood;Blood Circulation;Bone Marrow;Brain;Brain Stem;CCL3 gene;CCR1 gene;CCR5 gene;Cell Communication;cell type;Cells;Central Nervous System;Cerebral hemisphere;Cessation of life;chemokine;Child;Childhood;Childhood Brain Neoplasm;childhood cancer mortality;Childhood Glioma;Clinical;clinically relevant;Combined Modality Therapy;CXCL1 gene;Data;design;Diffuse intrinsic pontine glioma;Disease;DNA copy number;driver mutation;Flow Cytometry;Foundations;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Engineering;Genetically Engineered Mouse;Genomics;Genotype;Glioma;Goals;Growth;Heterogeneity;Histones;Human;IL8RB gene;Immune;Immunocompetent;Immunofluorescence Immunologic;In Vitro;Infiltration;Inflammatory;insight;Invaded;Knowledge;Location;Macrophage;Malignant Childhood Neoplasm;Microglia;Modality;Modeling;Molecular;Molecular Profiling;monocyte;mouse model;Mus;Mutation;Myelogenous;Myeloid Cells;nano-string;Nature;neutrophil;Neutrophil Infiltration;new therapeutic target;Newborn Infant;novel;Oncogenic;Outcome Study;patient subsets;Patients;PDGFA gene;PDGFB gene;pharmacologic;Population;Prognosis;Property;public health relevance;Radiation;recruit;Research;response;Role;Sampling;single-cell RNA sequencing;Slice;standard of care;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Time;Tissue Sample;tool;transcriptome sequencing;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages;tumor-immune system interactions

PROJECT_TITLE: The role of Myeloid cells in pediatric-high grade gliomas

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer;Prevention

PI_NAMEs: LENBURG, MARC ELLIOTT (contact)

PROJECT_TERMS: Academic Medical Centers;Address;adjudication;Administrator;Agreement;Biological Markers;biomarker development;biomarker discovery;biomarker evaluation;Boston;cancer biomarkers;clinic ready;Clinical;clinical center;Clinical Data;Clinical Research;Collaborations;Communication;Communities;Data;Data Collection;data warehouse;Decision Making;Development;Diagnosis;Early Detection Research Network;Enrollment;Ensure;Evaluation;Fostering;Funding;Goals;innovation;insight;Institution;investigator training;Laboratories;laboratory development;Leadership;lung cancer screening;Malignant neoplasm of lung;member;Modification;Molecular;Monitor;mortality;multidisciplinary;novel strategies;operation;Policies;Principal Investigator;Privatization;Procedures;Process;programs;Progress Reports;Protocols documentation;Publications;Qualifying;recruit;Research;Research Personnel;Resources;Site Visit;Standardization;success;synergism;translational pipeline;Universities;Validation;Work

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Lung;Lung Cancer;Precision Medicine;Prevention

PI_NAMEs: DUBINETT, STEVEN M. (contact)

PROJECT_TERMS: Algorithms;Benign;Biological Markers;biomarker development;biomarker discovery;biomarker performance;Boston;Bronchoscopy;cancer biomarkers;Categories;Cells;Characteristics;chest computed tomography;Chest imaging;Clinical;Clinical Management;clinically actionable;cohort;Collaborations;commercialization;computed tomography screening;Coupled;Cytometry;Data;deep learning;design;Detection;Diagnosis;Diagnostic Procedure;Diameter;Early Detection Research Network;efficacy evaluation;Eligibility Determination;follow-up;Gene Expression;Genetic Markers;Goals;Guidelines;high risk;histological specimens;Image;Image Analysis;imaging biomarker;improved;Individual;Industrialization;Inferior nasal concha;Laboratories;laboratory development;learning network;low dose computed tomography;lung cancer screening;Lung nodule;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Modeling;Molecular;multimodality;Neoplasm Circulating Cells;Nodule;Non-Invasive Detection;Nose;Observational Study;patient stratification;Patients;Performance;Peripheral Blood Mononuclear Cell;Persons;Population;Prevalence;Procedures;Recommendation;Risk;risk stratification;Sampling;Solid;Standardization;Testing;Time;Uncertainty;United States Preventative Services Task Force;Universities;Work;X-Ray Computed Tomography

PROJECT_TITLE: Biomarker Development Lab


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE This project will contribute to our understanding of how metabolic pathways regulate the differentiation and function of immune cells, as well as how metabolic conditions in the tumor microenvironment regulate the activity of tumor-associated antigen-presenting cells. It will also further elucidate how selective inhibition of glutamine metabolism can augment the efficacy of immune checkpoint blockade in order to more effectively treat malignancies that are resistant to the effects of immunotherapy. Lastly, it will seek to improve the treatment options available to treat late-stage soft tissue sarcoma.

PI_NAMEs: LOBEL, GRAHAM  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: amino acid metabolism;Amino Acids;antagonist;anti-tumor immune response;Antigen-Presenting Cells;antiport;biosynthetic product;cancer immunotherapy;Cell Differentiation process;Cell Physiology;cell type;Cells;Cessation of life;Characteristics;Complex;conditional knockout;Connective Tissue;cytokine;Dendritic Cells;Dependence;deprivation;Disease;Doxycycline;Engineering;Enzymes;fibrosarcoma;Flow Cytometry;FRAP1 gene;Generations;Genetic Transcription;Glucosamine;Glutamates;Glutaminase;Glutamine;glycosylation;Granulocyte-Macrophage Colony-Stimulating Factor Receptors;Hexosamines;Immune;immune checkpoint blockade;immune function;Immune signaling;Immune system;Immunologic Receptors;immunosuppressive macrophages;Immunotherapeutic agent;Immunotherapy;immunotherapy clinical trials;Implant;improved;in vitro Model;Incubated;Infiltration;Inflammatory;inhibitor;insight;Intercellular Fluid;Isotope Labeling;knock-down;Knock-out;Knockout Mice;Label;Leucine;liquid chromatography mass spectrometry;Macrophage;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;Modeling;monocyte;Mus;Myelogenous;Myeloid Cells;novel therapeutic intervention;Pathway interactions;Population;Process;Production;Protein Glycosylation;receptor;Resistance;Role;Shapes;Signal Pathway;Sirolimus;Soft tissue sarcoma;Survival Rate;synergism;T-Cell Activation;T-Lymphocyte;Testing;Tetanus Helper Peptide;Time;transcriptome sequencing;tumor;Tumor Antigens;tumor growth;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;Tumor-infiltrating immune cells;Work

PROJECT_TITLE: The Role of Glutamine Metabolism in Monocyte-Derived Dendritic Cell Differentiation in the Soft-Tissue Sarcoma Microenvironment


PI_NAMEs: PALAZZOLO, MICHAEL J (contact)

PROJECT_TERMS: Algorithms;analysis pipeline;Archives;Biological Assay;Biological Markers;biomarker discovery;biomarker identification;Blinded;Blood specimen;Boston;cancer biomarkers;candidate marker;Cells;Cellular Assay;Characteristics;chest computed tomography;Clinical;Clinical Data;Clinical Research;Collaborations;Data;data quality;Data Set;effectiveness evaluation;Engineering;Environment;Gene Expression;Genetic Markers;Genomics;Goals;Image;Image Analysis;imaging biomarker;Industrialization;Laboratories;lung cancer screening;Malignant neoplasm of lung;Measures;Modeling;Molecular;nasal swab;Neoplasm Circulating Cells;Nose;novel;Performance;Peripheral Blood Mononuclear Cell;Physicians;prediction algorithm;Process;prospective;Prospective cohort;Protocols documentation;Quality Control;Reference Standards;Reproducibility;Retrospective cohort;Risk;Running;scale up;Scanning;Site;Specificity;Specimen;Techniques;Testing;Universities;Validation;Work

PROJECT_TITLE: Biomarker Reference Lab


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: Newark

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Lay Summary The number of obese people has increased dramatically during the past few decades, and many develop diabetes. More than half of diabetic patients develop cardiac dysfunction characterized by mitochondrial dysfunction. Although normal heart cells are capable of removing problematic mitochondria immediately, this mechanism is impaired in diabetic patients. We will investigate the molecular mechanisms by which heart cells remove dysfunctional mitochondria and how these mechanisms are altered in the presence of diabetes. Our study may lead to the development of novel interventions to improve the quality of heart cell mitochondria, which should, in turn, prevent cardiac dysfunction in diabetic patients.

PI_NAMEs: SADOSHIMA, JUNICHI  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Aging;Autophagocytosis;Autophagosome;Biogenesis;Cardiac;Cardiac Myocytes;cell type;ChIP-seq;Chronic;Chronic Phase;Consumption;Development;Diabetes Mellitus;diabetic cardiomyopathy;diabetic patient;Differentiation and Growth;Excision;Functional disorder;Funding;Genes;Genetic Transcription;Goals;Heart;heart cell;Heart Diseases;Heart failure;Heart Hypertrophy;High Fat Diet;Homeostasis;Impairment;improved;in vivo;Inflammation;Intervention;Ischemia;Knockout Mice;Knowledge;lipidomics;loss of function;Mediating;Metabolism;Mitochondria;mitochondrial dysfunction;Molecular;Morphology;mouse model;Mus;Myocardial dysfunction;myocardial injury;novel;obese person;Organelles;Parkin;Pathologic;Phase;Play;prevent;Production;programs;Property;protein complex;Proteins;Quality Control;response;RIPK1 gene;Role;Stress;Testing;TFE3 gene;Transcription Coactivator;transcriptome;Up-Regulation

PROJECT_TITLE: Removal of damaged mitochondria by alternative autophagy

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Data Science;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Precision Medicine;Prescription Drug Misuse;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative Current in vitro assays and in vivo models designed to study the pathophysiology of opioid use disorder (OUD) and to discover potential therapeutic targets are useful, but there is a need for additional model systems. Our research strategy involves the use of induced pluripotent stem cell (iPSC)-derived 3D brain organoids and single-cell sequencing technology to identify molecular signatures for OUD using two commonly prescribed synthetic opioids: oxycodone and fentanyl as molecular probes. This approach will make it possible to advance our understanding of both drug action and of disease pathophysiology at the single-cell level.

PI_NAMEs: HO, MING-FEN  (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: 3-Dimensional;addiction;Address;Affect;Automobile Driving;behavioral response;Big Data;Bioinformatics;Biological;Biological Models;Biology;Brain;brain cell;Buprenorphine;Cell Physiology;cell type;Cells;Characteristics;Chromatin;Chromium;Clinic;Cocaine;Computing Methodologies;Corpus striatum structure;Data;design;Disease;Dorsal;drug action;drug mechanism;Drug usage;experience;Fentanyl;fentanyl exposure;Functional disorder;functional genomics;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Genomics;Goals;immune function;in vitro Assay;in vivo Model;induced pluripotent stem cell;induced pluripotent stem cell technology;innovation;insight;Interferon Activation;Interferon Type I;Interferons;Libraries;Link;Medicine;model design;Modeling;Molecular;molecular phenotype;Molecular Probes;Molecular Profiling;Morphine;multiple omics;Mus;myelination;Neuroglia;Neurons;new therapeutic target;novel;novel therapeutics;Oligodendroglia;Opiate Addiction;Opioid;opioid use disorder;Organoids;overdose death;Oxycodone;oxycodone self-administration;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacogenomics;Pharmacotherapy;Phenotype;preclinical study;prescription opioid;Prevention;Property;Prosencephalon;Rattus;Regulon;Reporting;Research;Resolution;response;Sea;self assembly;Signal Pathway;Signal Transduction;single cell sequencing;single nucleus RNA-sequencing;single-cell RNA sequencing;Standardization;STAT1 gene;Structure;Substance Use Disorder;synthetic opioid;Technology;Testing;Therapeutic Agents;therapeutic target;tool;transcription factor;Transcriptional Regulation;Validation;Ventral Striatum;XCL1 gene

PROJECT_TITLE: Single cell multi-omics of iPSC-derived brain organoids from patients with opioid use disorder: synthetic opioids as molecular probes

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative The brain’s ability to accurately predict the sensory outcome of our actions is critical for many aspects of behavior in health and disease, but the cellular pathways that learn and implement these predictions are not well understood. This proposal will apply state-of-the-art behavioral, physiological, and computational techniques in concert with one another to understand how sensory-motor predictions are implemented mechanistically across multiple interacting brain regions. These experiments will provide critical insight into how distributed circuits work together to facilitate hearing and identify key circuit elements that may contribute to the dysfunction of flexible sensory processing.

PI_NAMEs: AUDETTE, NICHOLAS J (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TITLE: To identify mechanisms of predictive processing across the distributed thalamocortical circuit

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Neurosciences;Prostate Cancer;Rehabilitation;Urologic Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Maintaining cognitive health represents a key priority for older survivors of prostate cancer. The goal of this project is to advance scientific understanding of cognitive dysfunction in prostate cancer survivors and to evaluate an acupuncture treatment for this debilitating condition. This research addresses an important public health issue for the aging population and has the potential to lead to novel therapies to promote cognitive health and well-being in millions of cancer survivors.

PI_NAMEs: LIOU, KEVIN T (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Acupuncture Therapy;Address;Advanced Malignant Neoplasm;Affect;Aging;aging population;American Cancer Society;androgen deprivation therapy;Anxiety;Applications Grants;associated symptom;Attention;Award;Biometry;Breast Cancer Patient;Cancer Etiology;Cancer Model;Cancer Survivor;cancer survivorship care;cancer therapy;cancer type;cancer-related cognitive impairment;career development;Chinese Traditional Medicine;Clinical Trials Design;Cognitive;cognitive function;Cognitive Therapy;Competence;Cross-Sectional Studies;Data;design;Educational workshop;efficacy testing;Elderly;epidemiology study;Evaluation;Evidence based treatment;executive function;Fatigue;Foundations;Functional disorder;functional independence;Goals;Grant;Guidelines;Health;health management;Impaired cognition;Impairment;improved;Institution;instrument;Integrative Medicine;Integrative Therapy;International;Intervention;K-Series Research Career Programs;Learning;Literature;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;Medicine;Memorial Sloan-Kettering Cancer Center;Memory;Mental Depression;Mentors;Mentorship;NCI-Designated Cancer Center;Neurocognitive;Neuropsychology;neurotoxic;neurotoxicity;Nocturia;Nonpharmacologic Therapy;novel;novel therapeutics;older adult;Older Population;Oncology;Outcome;Personal Satisfaction;Pharmaceutical Preparations;Population;Positioning Attribute;post intervention;Preparation;preservation;primary outcome;programs;prostate cancer survivors;Prostate Cancer therapy;Public Health;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Recording of previous events;Research;Research Personnel;Resources;Role;Scientific Advances and Accomplishments;skills;Sleeplessness;Societies;sociodemographics;Subgroup;Survivors;symposium;symptom management;symptom science;Symptoms;Testing;therapy development;Training;treatment as usual;trial enrollment;United States;urinary;Verbal Learning;Waiting Lists;Work;Writing

PROJECT_TITLE: Acupuncture for Cognitive Health in Older Survivors of Prostate Cancer (ACHIEVE)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pregnancy;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Thalidomide and its analogs have proven to be an extremely effective treatment for hematologic malignancies and over the last decade they have demonstrated their versatility in the development of new therapeutic modalities. Despite their therapeutic potential, the molecular mechanisms of their devastating teratogenicity remain ambiguous, which we will resolve through the proposed studies. This grant further aims to push the boundaries of these molecules to target new classes of undruggable proteins ultimately leading to novel cancer therapeutics.

PI_NAMEs: FISCHER, ERIC SEBASTIAN (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: 8p11;Acute;Address;Affect;Alleles;analog;Binding;Biological;Biological Models;Birth;C2H2 Zinc Finger;cancer therapy;casein kinase I;Cells;Characteristics;Chemicals;Chemistry;Child;Chimeric Proteins;chromosome 5q loss;Clinic;Clinical;clinical development;Complex;Congenital Abnormality;consanguineous family;Data;Development;Dysmyelopoietic Syndromes;effective therapy;Embryo;Engineering;Eukaryota;Explosion;Family;FDA approved;FGFR1 gene;Future;gain of function;Glues;Goals;Grant;Hematologic Neoplasms;Human;human embryonic stem cell;Human Genetics;immune modulating agents;in vivo;in vivo Model;inhibitor;insight;Knock-in;Lead;Learning;lenalidomide;Ligase;loss of function;Malignant Neoplasms;Marketing;Mass Spectrum Analysis;Measurement;Mediating;member;Memory;Missense Mutation;Modality;Molecular;Morning Sickness;mouse model;Multiple Myeloma;Mus;Mutation;Myeloproliferative disease;neurodevelopment;new therapeutic target;novel;novel therapeutics;Oncogenes;Oncogenic;Pharmaceutical Preparations;Pharmacotherapy;Phenocopy;Phocomelia;phosphoric diester hydrolase;Physiological;Play;pomalidomide;preclinical development;Pregnancy;Pregnant Women;prevent;protein degradation;Proteins;Proteomics;rational design;RBX1 gene;Recording of previous events;recruit;Research;Resources;response;Role;scaffold;Self Mutilation;severe intellectual disability;small molecule therapeutics;standard of care;Structure;Syndrome;targeted treatment;Technology;Teratogenic effects;Teratogens;Testing;Thalidomide;Therapeutic;Therapeutic Effect;Time;tool;Toxicity Tests;transcription factor;Type 1 Duane Retraction Syndrome;ubiquitin ligase;ubiquitin-protein ligase;Withdrawal;Work;Zinc Fingers

PROJECT_TITLE: The molecular basis of IMiD induced neo-substrate recruitment to the CRL4CRBN ubiquitin E3 ligase

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetic Testing;Genetics;Hepatitis;Liver Cancer;Liver Disease;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

PHR: Project Narrative This project will examine the hereditary genetics of Hepatocellular Carcinoma (HCC), a devastating cancer of the liver with well-defined environmental risk factors, but with an undefined inherited genetic component. Here, we will complete a genetic association study to determine whether patients with HCC harbor rare inherited variants in genes at higher rates than in control populations, which could guide clinical recommendations for genetic testing. We will also determine whether inherited defects increase cancer cell susceptibility to specific drug therapies, which could change clinical practice and improve survival.

PI_NAMEs: WANGENSTEEN, KIRK J (contact)

PROGRAM_OFFICER_NAME: CARRICK, DANIELLE M

PROJECT_TERMS: Address;Age;Age of Onset;Alcohol consumption;Alcohols;Animal Model;BRCA2 gene;cancer cell;cancer predisposition;cancer risk;Candidate Disease Gene;carcinogenesis;case control;CHEK2 gene;Chronic;Clinical;clinical center;clinical practice;clinically relevant;Confidence Intervals;Death Rate;Defect;Demographic Factors;Development;Diagnosis;DNA Damage;DNA Repair;DNA Repair Gene;early onset;Enrollment;Environmental Risk Factor;exome;Exposure to;Family;Family Cancer History;Family history of;Family member;FANCD2 protein;Fanconi Anemia Complementation Group A Protein;Fatty Liver;fatty liver disease;First Degree Relative;Gene Expression;gene function;gene panel;gene repair;Genes;Genetic;genetic association;Genetic Models;genetic panel test;genetic risk factor;Genetic study;genetic testing;genetic variant;genomic locus;Germ Lines;Germ-Line Mutation;Hepatitis B;Hepatitis C;Hereditary Neoplastic Syndromes;high risk;Histologic;homologous recombination;improved;Individual;Inherited;inhibitor therapy;innovation;Institution;Investigation;Knowledge;Link;liver cancer model;Liver neoplasms;loss of function;Loss of Heterozygosity;Malignant neoplasm of liver;Malignant Neoplasms;Medical center;MSH6 gene;novel therapeutic intervention;Odds Ratio;Outcome;Pathogenesis;Pathogenicity;Patient Care;patient subsets;Patients;personalized medicine;Pharmacotherapy;Phenotype;Pilot Projects;Play;PMS2 gene;Poly(ADP-ribose) Polymerase Inhibitor;Population;Population Control;Practice Guidelines;Predisposition;Primary carcinoma of the liver cells;prospective;Proteins;rare variant;Recommendation;Recording of previous events;repaired;response;Risk;Risk Factors;Role;Stains;Susceptibility Gene;targeted treatment;Test Result;Testing;Toxic Environmental Substances;treatment strategy;tumor;Tumor Tissue;Variant;Virus Diseases

PROJECT_TITLE: Hereditary Genetics of Hepatocellular Carcinoma

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular

PHR: Project Narrative This proposal promises to uncover new mechanisms of Nlrp3 inflammasome activation that are relevant to accelerated atherosclerosis, NETosis and plaque destabilization especially in the setting of dyslipidemia and TET2 clonal hematopoiesis. This research may help to promote the development of new approaches targeting deubiquitinase enzymes for the treatment of atherosclerosis.

PI_NAMEs: TALL, ALAN RICHARD (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Acceleration;Adverse effects;Anti-Inflammatory Agents;Area;Arterial Fatty Streak;atherogenesis;Atherosclerosis;ATP binding cassette transporter 1;Binding;calmodulin-dependent protein kinase II;Cells;Cholesterol;cholesterol trafficking;clinical application;Colchicine;Collaborations;Collagen;Complex;Development;DUSP6 protein;Dyslipidemias;endoplasmic reticulum stress;Enzymes;extracellular;Goals;Grant;Hematopoiesis;High Density Lipoproteins;Human;human induced pluripotent stem cells;improved;in vivo;Inflammasome;Inflammation;Inflammatory;Infusion procedures;inhibitor;insight;Knock-out;Lesion;Link;Low-Density Lipoproteins;Macrophage;Maps;Mediating;Methylation;Morbidity - disease rate;mortality;Movement;Mus;Mutation;Myeloid Cells;neutrophil;novel;novel strategies;Pathway interactions;Phosphoric Monoester Hydrolases;Phosphorylation;Population;Precision therapeutics;Predisposition;Process;promoter;reconstitution;Research;Residual state;Risk Factors;Role;Signal Pathway;Signal Transduction;Specificity;Sphingomyelinase;success;Transplantation;ubiquitin isopeptidase

PROJECT_TITLE: Cholesterol efflux, CHIP and inflammasome activation

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Health Services;Neurosciences;Sleep Research

ORG_DEPT: MISCELLANEOUS

PHR: NARRATIVE Long-term use of sedative hypnotics is associated with dependence, falls, fractures, high-risk parasomnias (sleepwalking, sleep-driving), and cognitive impairment. Despite this and guideline recommendations limiting their use, these drugs are the most popular pharmaceutical insomnia treatment. The objective of the Study in Outpatient Medicine using NUdges to improve Sleep (the SOMNUS Trial) is to develop and test behavioral nudges in a randomized trial to deprescribe these drugs and encourage the use of evidence-based therapies for insomnia in everyday clinical practice.

PI_NAMEs: DOCTOR, JASON N. (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: age related changes;Aging;American;Architecture;Automobile Driving;Behavior;behavior test;Behavior Therapy;Behavioral;behavioral economics;Behavioral Sciences;behavioral sleep intervention;Bibliotherapy;Caring;Chronic;Clinic;Clinical;clinical practice;Cognitive;Cognitive Therapy;Cost Savings;Data;Decision Making;Dependence;design;Drug Addiction;drug metabolism;Drug Prescriptions;Drug usage;Education;Educational Materials;Electronic Health Record;Eszopiclone;evidence base;Evidence based practice;falls;Fracture;Future;Guidelines;Health;high risk;hypnotic;Impaired cognition;implementation research;implementation strategy;improved;improvement on sleep;insight;interest;Intervention;Link;Literature;Medicine;Midwestern United States;Modeling;models and simulation;multiple chronic conditions;National Heart, Lung, and Blood Institute;older adult;Outcome;Outcome Measure;Outpatients;Parasomnias;Patients;Perception;Performance;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Physicians;pill;Polypharmacy;Population;population health;prescription opioid;preservation;primary care clinic;primary outcome;Probability;Process Measure;provider behavior;Quality of life;Randomized;randomized trial;Recommendation;Resources;response;Safety;Sample Size;screening;secondary outcome;Sedation procedure;sedative;simulation;Sleep;Sleep Disorders;sleep health;sleeping pill;Sleeplessness;Social Accountability;Somnambulism;Surveys;Telephone;Text;Update;vehicular accident;Visit;Work;Zaleplon;zolpidem

PROJECT_TITLE: Study in Outpatient Medicine using Nudges to improve Sleep: The SOMNUS Trial

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


PHR: PROJECT NARRATIVE Despite recent advances in anti-PD-1 immunotherapy, not all patients respond favorably and cancer remains the second leading cause of death in the US. Studying the inhibitory transmembrane protein Phosphoprotein Associated with Glycosphingolipid Rich Microdomains 1 (PAG), a downstream target of PD-1 signaling, will help us better understand the PD-1 pathway, and offer another, perhaps more nuanced target to improve response rates and/or avoid adverse effects. PAG links lipid-rich regions of the membrane to the actin cytoskeleton, and its study will illuminate crucial control mechanisms associated with T cell synapse organization, opening more methods to therapeutically target the immune synapse.

PI_NAMEs: MOORE, EMILY KATHRYN (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Actins;Adhesions;Adoptive Cell Transfers;Adverse effects;Anatomy;anti-PD-1;anti-PD1 antibodies;Antibodies;antibody immunotherapy;Antibody Therapy;Antigen-Presenting Cells;Antitumor Response;Architecture;Autoimmune Diseases;Automobile Driving;Binding;Biological Assay;C-terminal;cancer cell;cancer immunotherapy;cancer therapy;career;Cause of Death;CD28 gene;Cell Line;Cell membrane;Cell Physiology;Cells;Clinical;Complex;Confocal Microscopy;cytokine;Cytoskeleton;cytotoxicity;Enzyme-Linked Immunosorbent Assay;Enzymes;Event;Fellowship;Flow Cytometry;Fluorescence Resonance Energy Transfer;Fostering;Future;Glycosphingolipids;Goals;Human;Imaging Techniques;Immune;immune cell infiltrate;Immune checkpoint inhibitor;immune function;Immune response;Immune Targeting;immune-related adverse events;immunological synapse;Immunology;immunoregulation;Immunotherapy;improved;in vivo;innovation;Integral Membrane Protein;interest;Knock-out;Ligand Binding;Ligation;Link;Lipids;Malignant Neoplasms;MAP Kinase Gene;Measures;Mediating;Medicine;Membrane;Membrane Microdomains;Mentorship;Methods;Mind;Modeling;mortality;Mus;Mutate;new therapeutic target;novel;novel therapeutics;Palmitic Acylation Site;Pathway interactions;Patients;Pattern;Peripheral;pharmacologic;Phosphoproteins;Phosphorylation;Physicians;polymerization;Polymers;prevent;Process;Production;programmed cell death protein 1;Proliferating;protein protein interaction;Proteins;recruit;Regimen;Research;Research Personnel;Resources;response;Role;Shapes;Signal Pathway;Signal Transduction;Signaling Protein;skill acquisition;skills;Structure;Synapses;synaptic function;synaptogenesis;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;targeted cancer therapy;targeted treatment;Technology;Testing;Therapeutic;Therapeutic antibodies;therapeutic target;Total Internal Reflection Fluorescent;tumor;Tyrosine Phosphorylation Site;Visualization;Work

PROJECT_TITLE: Contribution of PAG to Immune Synapse Organization and PD-1 Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07A-A(20)]


ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The EphB4-p120RasGAP signaling axis is critical for vascular development and mutations in both EphB4 and p120RasGAP are associated with vascular disorders including Vein of Galen Malformation and Capillary Malformation-Arteriovenous Malformation Syndrome. Despite its importance, there are still large gaps in knowledge about how p120RasGAP is regulated by binding partners. My proposed studies will provide a molecular understanding of p120RasGAP’s regulation and the disruption of this regulation by disease mutations.

PI_NAMEs: VISH, KIMBERLY JEAN (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Affect;Affinity;Area;Arteries;Arteriovenous malformation;base;Binding;Binding Sites;Biochemical;Biological Assay;Biophysics;Blood;Blood capillaries;Blood Circulation;Blood Vessels;Brain;Calorimetry;Cell Extracts;Cells;Complex;Data;Development;Disease;disease phenotype;Family;Fluorescence;Galen Vein;GRLF1 gene;GTPase-Activating Proteins;Guanosine Triphosphate;In Vitro;Investigation;Knowledge;Length;malformation;Maps;Measures;Molecular;Molecular Conformation;mutant;Mutation;N-terminal;Newborn Infant;Outcome;p120 GTPase Activating Protein;Pathogenicity;Pathway interactions;Patients;Peptides;Phosphopeptides;Phosphorylation;Phosphotyrosine;protein purification;Proteins;RAS genes;ras GTPase-Activating Proteins;Receptor Protein-Tyrosine Kinases;recruit;Regulation;rho;rho GTPase-activating protein;Roentgen Rays;Signal Transduction;src Homology Region 2 Domain;Structure;Syndrome;Tertiary Protein Structure;Testing;Titrations;Tyrosine Phosphorylation;Vascular Diseases;Work;X-Ray Crystallography

PROJECT_TITLE: Structural Investigation of p120RasGAP's regulation by phosphorylated binding partners


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative  The epidermis is a multi-layered tissue composed primarily of cells called keratinocytes, which undergo a specialized maturation process to continually regenerate the skin’s outermost layers to prevent dehydration and infections. Fully mature keratinocytes must degrade their nuclei and organelles to form these compacted, protective layers, however, this step is compromised in patients with rare skin barrier disorders like ichthyosis and Darier disease but also in those with common diseases including atopic dermatitis and psoriasis. This project will use gene editing and advanced microscopic imaging to understand keratinocyte maturation with the long-term goal of identifying new ways to improve the skin’s barrier function and treat dermatologic disorders.

PI_NAMEs: SIMPSON, CORY L (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Acceleration;Address;Atopic Dermatitis;Automobile Driving;Autophagocytosis;Autophagosome;Award;BCL2/Adenovirus E1B 19kd Interacting Protein 3-Like;Binding;Biological Process;Biological Response Modifier Therapy;Biosensor;Body Surface;Buffers;Calcium;candidate identification;career development;Cell Differentiation process;cell injury;Cell Nucleus;Cells;Cellular biology;Clinical;Compensation;Confocal Microscopy;Data;Degradation Pathway;Dehydration;Dermatologic;Dermatology;Development;Disease;Electrons;Endoplasmic Reticulum;endoplasmic reticulum stress;Ensure;Epidermis;Epithelium;experimental study;Functional disorder;Funding;Future;gain of function;Genes;Goals;Histologic;Homeostasis;Human;human tissue;Ichthyoses;Image;improved;in vivo;Infection;Inflammatory;Inherited;Injury;innovation;Invaded;Investments;keratinization;keratinocyte;keratinocyte differentiation;Keratosis Follicularis;Knock-out;Knowledge;Lasers;Life;Link;loss of function;Lysosomes;Mediating;Mediator;medical specialties;Membrane;Methods;Microscopic;microscopic imaging;Microscopy;Mitochondria;Modeling;Morphogenesis;Natural regeneration;novel;novel strategies;optogenetics;Organelles;pathogen;Pathology;Pathway interactions;Patients;Physicians;Positioning Attribute;premature;prevent;Process;programs;protein expression;Psoriasis;rational design;Reactive Oxygen Species;receptor;repaired;Reporting;Research;Research Personnel;resilience;Role;Route;Scientist;sensor;Signal Transduction;Skin;skin barrier;skin disorder;skin regeneration;stressor;success;targeted treatment;Testing;Tissue Model;Tissues;tool;Toxic effect;transcriptome sequencing;Tubular formation;Universities;Up-Regulation;Washington;Work

PROJECT_TITLE: Mechanisms of reticulophagy and ER stress mitigation in epidermis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because a better understanding of the neurobiology underlying autism spectrum disorder will lead to improved methods for prevention and treatment. The proposed research is relevant to the part of the NIMH’s mission that pertains to understanding mental illnesses through basic research.

PI_NAMEs: DE RUBEIS, SILVIA  (contact);WU, ZHUHAO

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;autism spectrum disorder;Automobile Driving;axonal pathfinding;Basic Science;Behavior;Behavior monitoring;Behavioral;behavioral outcome;behavioral phenotyping;Biology;Brain;Brain Mapping;Brain region;brain shape;Brain Stem;Cell Nucleus;cell type;Cells;clinical phenotype;Complex;Data;Defect;Development;Diagnosis;Disease;DNA Sequence Alteration;Embryo;Exposure to;Face;Female;FOS gene;Gene Expression;Genes;Genetic;genetic approach;genetic disorder diagnosis;Goals;high risk;hindbrain;Hyperactivity;Immediate-Early Genes;Impaired cognition;improved;in vivo;Individual;innovation;insight;Intervention;Label;Laboratories;Link;loss of function mutation;male;Maps;Measures;Mental disorders;Messenger RNA;Metabolism;Methods;Mission;Modeling;Molecular;Molecular Profiling;Morphology;mouse model;multimodality;Mus;mutant;Mutation;National Institute of Mental Health;neural;neural circuit;Neurobiology;Neurodevelopmental Disorder;neurogenesis;neuromechanism;Neurons;new therapeutic target;novel;novel therapeutic intervention;Pattern;Pharmacological Treatment;Population;postnatal;precision medicine;Preclinical Testing;prevent;Prevention;Proliferating;Proteins;Proteomics;Proxy;Public Health;Publishing;pup;Research;Resolution;response;Risk Factors;risk variant;RNA Helicase;Role;Scanning;Sex Differences;Signal Transduction;single cell sequencing;single nucleus RNA-sequencing;social;Stimulus;synaptogenesis;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Thinness;Tissues;Training;transcriptomics

PROJECT_TITLE: Global mapping of altered neural circuits in a mouse model of DDX3X mutations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(57)]


NIH_SPENDING_CATS: Cancer

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on developing an understanding of the relationship between cell proliferation and cell invasion which is critical for identifying therapeutic strategies that simultaneously inhibit tumor growth and metastasis. Once such strategies have been identified, there is the potential for a significant advance in cancer therapy for patients with advanced malignancies. Thus, the proposed research is relevant to the part of the NCI’s mission that pertains to advancing scientific knowledge and helping all people live lengthier, healthier lives.

PI_NAMEs: MARTINEZ, MICHAEL ADRIAN (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;Alleles;Animals;Automobile Driving;Basement membrane;Behavior;Biological Phenomena;Breast;Caenorhabditis elegans;cancer cell;cancer therapy;cancer type;CDK4 gene;cell behavior;Cell Cycle;Cell Cycle Arrest;Cell Cycle Regulation;Cell model;Cell Proliferation;Cells;Cellular Structures;Clinical;Clinical Treatment;Clinical Trials;cyclin-dependent kinase inhibitor 1B;Data;design;Development;Down-Regulation;egg;Event;FDA approved;Fellowship;FRAP1 gene;Future;G0 Phase;Genes;Genetic;Goals;high resolution imaging;Homologous Gene;Human;Image;In Vitro;in vivo;in vivo Model;Individual;inhibitor;Invaded;knock-down;Knowledge;Liver;Lung;Maintenance;Malignant Neoplasms;Melanoma;Metastatic breast cancer;Mission;Modeling;Molecular;mTOR inhibition;mutant;Nematoda;Neoplasm Metastasis;neoplastic cell;novel;Nuclear Hormone Receptors;Outcome;pancreatic cancer cells;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenocopy;preclinical study;prevent;Process;Proliferating;Proteins;Public Health;Puncture procedure;Regulation;Research;Scientific Advances and Accomplishments;senescence;sensor;System;Techniques;Technology;Testing;Therapeutic;translational impact;treatment strategy;tumor growth;Uterus;Vulva;Work

PROJECT_TITLE: Elucidating the Relationship Between Cell Proliferation and Invasion

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Digestive Diseases;Genetics;Intellectual and Developmental Disabilities (IDD);Liver Disease;Nanotechnology;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative Impaired function of ATP Binding Cassette transporters of the D subfamily underlies a wide array of serious metabolic and neurological diseases such as X-linked Adrenoleukodystrophy, a rare genetic disorder caused by mutations in ABCD1 that can be fatal and for which no cure exists, and other defects caused by impaired fatty acid and phospholipid processing. This project focuses on detailed structure-function studies on the peroxisomal fatty acid transporters ABCD1, ABCD2, and ACBD3 to understand how they work at the molecular level to aid in future design and development of diagnostic and therapeutic tools to combat diseases stemming from their dysfunction.

PI_NAMEs: ALAM, AMER  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: ACBD3 gene;Acceleration;Adrenoleukodystrophy;ATP Hydrolysis;ATP-Binding Cassette Transporters;Bile Acid Biosynthesis Pathway;Bile Acids;Binding;Biochemical;Biological;Biological Assay;branched chain fatty acid;Catabolism;Cells;Chemicals;Coenzyme A;combat;Cryoelectron Microscopy;Cysteine;Data;Defect;design;Development;Diagnostic;diagnostic development;Disease;Disease Pathway;drug development;Electron Spin Resonance Spectroscopy;Elements;Environment;Esterification;Esters;Family;fatty acid metabolism;fatty acid transport;Fatty Acids;Functional disorder;Functional impairment;Future;Genes;Human;hydrophilicity;Impairment;improved;in silico;In Vitro;in vitro Assay;insight;Label;Length;leukodystrophy;Link;Lipid Bilayers;Lipid Chemistry;Lipids;Liposomes;Liver diseases;Location;Measures;Mediating;Membrane;Membrane Transport Proteins;Metabolic;Metabolic Diseases;Molecular;Molecular Conformation;mutant;Mutation;nanodisk;Nervous System Disorder;Neurologic;Nucleotides;Pathologic;Pathology;Pathway interactions;Patient-Focused Outcomes;Pattern;Peroxisomal Disorders;peroxisome;Phenotype;Phospholipids;Physiological;Production;Property;Proteins;proteoliposomes;rare genetic disorder;reconstitution;Regulation;Resolution;Role;Scanning;Shapes;small molecule;Specificity;Spin Labels;stem;structural determinants;Structure;Substrate Specificity;Therapeutic;tool;Transmembrane Transport;Very Long Chain Fatty Acid;Work

PROJECT_TITLE: Molecular basis of fatty acid transport by peroxisomal ABC transporters

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE  Sexual minority and gender minority (SGM) individuals are more likely to have poor physical health than their non-SGM peers. In this proposal, we will test if SGM people are more likely to have higher levels of cardiovascular disease (CVD) risk factors than non-SGM people and determine if stigma against SGM people contributes to increased risk for poor CVD outcomes in these populations at the intersections of race/ethnicity, sex, and socioeconomic status. As part of our larger goal to not only decrease SGM CVD but also to enhance SGM cardiovascular health equity, we will investigate if resilience promoting factors can mediate the harmful health effects of stigma to improve the health of diverse SGM populations.

PI_NAMEs: BEACH, LAUREN BRITTANY (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Address;adjudication;Adult;aged;Ancillary Study;Behavior assessment;behavior measurement;Behavioral;biobehavior;Black race;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;cardiovascular health;Cholesterol;Chronic stress;Clinical;clinical development;clinical risk;cohort;Collaborations;Communities;community center;Coronary artery;County;Data;Development;Diabetes Mellitus;Diet;Discrimination;Disease;disease disparity;Disease Outcome;Disparity;Distal;Distress;enhancing factor;Ethnic Origin;Evaluation Reports;evidence base;experience;Funding;Gender Identity;gender minority;gender minority community;gender minority group;gender minority health;gender minority status;Goals;Health;health disparity;health equity;Health Promotion;High Prevalence;Hispanic;Hispanic Community Health Study;Household;Hypertension;improved;Incidence;Individual;innovation;internalized stigma;Investigation;Latino;Latino Population;Laws;lens;Life Cycle Stages;Link;Literature;Longitudinal cohort study;marginalization;marginalized population;Measures;Mediating;Mental Depression;minority disparity;minority health disparity;minority stress;Modeling;National Heart, Lung, and Blood Institute;Obesity;Outcome;Participant;Pathway interactions;Patient Self-Report;peer;Persons;physical conditioning;physical inactivity;Policy Maker;Population;population health;Population Heterogeneity;Prevalence;promote resilience;psychological distress;psychological outcomes;psychosocial;Race;Research Personnel;Resources;Risk;Risk Behaviors;Risk Factors;Same-sex;sex;Sex Orientation;Sexual and Gender Minorities;sexual minority group;Smoking;Social Power;social stigma;Social support;Socioeconomic Status;Stigmatization;Stress;stressor;System;Testing;theories;Time;young adult

PROJECT_TITLE: Cardiovascular Health Associations with Minority stress: Biobehavioral Evaluations and self-Reported Sociopsychological outcomes by SOGI status (CHAMBERS)

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Health-relatedness statement This program proposes continuing the Research Track Radiology Residency Program, which incorporates research training into the clinical radiology residency. This will produce clinician-scientists who can perform high-quality imaging research that is relevant and translatable to patient care.

PI_NAMEs: GADE, TERENCE P;MANKOFF, DAVID A. (contact);SCHNALL, MITCHELL D.

PROGRAM_OFFICER_NAME: ERIM, ZEYNEP

PROJECT_TITLE: Research Track Radiology Residency


ADMINISTERING_IC: MD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sexually Transmitted Infections;Social Determinants of Health;Urologic Diseases;Vaccine Related;Women's Health Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF MASSACHUSETTS BOSTON

PHR: PROJECT NARRATIVE The proposed study seeks to assess Cape Verdean parents’ awareness, knowledge, attitudes, and behaviors related to the human papillomavirus (HPV), and acceptability and uptake HPV vaccination by their adolescents. This information is important to develop culturally sensitive HPV-related cancer education and prevention interventions that meet the specific needs of Cape Verdeans living in the United States.

PI_NAMEs: LINDSAY, ANA CRISTINA TERRA DE SOUZA (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: 18 year old;Acculturation;Address;Adolescent;African;African American population;African ancestry;Age;Attitude;Awareness;Belief;Black Populations;black women;cancer health disparity;Cancer Prevention Intervention;cancer risk;Cape Verde;carcinogenicity;care seeking;Child Rearing;Church;Communities;community engaged research;contextual factors;cost effective;Country;Data;Daughter;Death Rate;design;Disproportionately impacts women;Educational Intervention;Eligibility Determination;ethnic minority;ethnic minority population;Ethnic Origin;expectation;Family;Fathers;Focus Groups;Funding Mechanisms;Future;Gender;Genotype;Goals;Health;health communication;Health Disparities Research;Health Knowledge Attitudes Practice;health literacy;Health Status;Healthcare;Home;HPV vaccine acceptance;HPV vaccine hesitancy;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immigrant;improved;Incidence;Individual;innovation;Intention;Investments;Justice;Knowledge;Legal Guardians;Length;Linguistics;Link;Literature;Logistic Regressions;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant neoplasm of penis;Malignant neoplasm of vulva;Malignant Neoplasms;malignant oropharynx neoplasm;Malignant Vaginal Neoplasm;Massachusetts;member;Minority;Minority Groups;Morbidity - disease rate;mortality;Mothers;Not Hispanic or Latino;Outcome;parental influence;Parents;Phase;Population;Population Group;Portuguese;premalignant;Prevalence;prevent;preventive intervention;Protestant;psychosocial;Public Health;Race;Racial Equity;racial health disparity;Reporting;Research;Residencies;Rhode Island;Science;sexually transmitted virus;social culture;sociocultural determinant;Solid;Son;Subgroup;Surveys;Testing;United States;uptake;vaccine hesitancy;vaccine refusal;Vaccines

PROJECT_TITLE: Toward Racial Equity and Justice in Human Papillomavirus (HPV) Vaccination: An Exploratory Study with Cape Verdean Parents

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: NARRATIVE –  Malignant prostate cancer is a leading killer of men and new approaches to reduce tumor burden and extend life. PSMA-targeted molecular radiotherapy, in which cancer cells are irradiated with biological specificity, is a promising approach that is currently limited by background toxicity to radiosensitive organs including the salivary glands and kidney. We propose a potent strategy that eliminates non-tumor organ uptake of PSMA molecular radiotherapy while retaining tumoricidal effect; resulting in improved therapeutic response with reduced toxicities.

PI_NAMEs: THOREK, DANIEL LYNDON JAFFE (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: Ablation;absorption;Address;Affect;Affinity;Alpha Particles;Anatomy;Animals;Antibodies;Autopsy;Autoradiography;Biodistribution;Biological;Biological Assay;cancer cell;Cancer Etiology;Cancer Patient;cancer radiation therapy;Cell surface;Cells;Cessation of life;Clinic;Clinical;Clinical Chemistry;clinical imaging;Clinical Treatment;Clinical Trials;comorbidity;Complete Blood Count;Coupled;cytotoxicity;Data;Detection;Development;Diagnostic;Diagnostic Imaging;Diameter;Discipline of Nuclear Medicine;Disease;disease model;Dose;drug development;Drug Kinetics;Eligibility Determination;Evaluation;falls;FOLH1 gene;Genes;Genetic Engineering;Goals;Human;human disease;Hybrids;Image;image translation;imaging agent;improved;inhibitor;insight;interest;Ionizing radiation;Isotopes;Kidney;Label;Length;Life;Ligand Binding;Ligands;Linear Energy Transfer;Location;Long-Term Care;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;man;Mediating;Medical;men;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Methods;Modeling;Molecular;molecular imaging;molecular oncology;Molecular Target;Monitor;Monitoring for Recurrence;mouse model;multidisciplinary;Normal tissue morphology;novel;novel strategies;optimal treatments;Organ;Outcome;Output;overexpression;particle;particle therapy;Pathologic;Pathology;Patient Care;patient population;Patients;Physics;pinacolyl methylphosphonic acid;Positron-Emission Tomography;prevent;Prodrugs;prophylactic;Prostate;prostate cancer model;Prostatic Neoplasms;quantitative imaging;Radiation Dose Unit;Radiation therapy;Radiation Tolerance;Radiochemistry;Radioisotopes;Radiolabeled;radioligand;radiological imaging;Radiology Specialty;Radiopharmaceuticals;Renal function;Reporting;Research Personnel;response;Role;Salivary;Salivary Glands;Schedule;Sea;serum PSA;side effect;single photon emission computed tomography;Site;small molecule;Specificity;subcutaneous;success;Survival Rate;synergism;targeted agent;Targeted Radiotherapy;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Time;Tissues;Toxic effect;Toxicology;Tracer;Translations;treatment response;tumor;Tumor Burden;uptake;Variant;Width;Xenograft procedure;Xerostomia

PROJECT_TITLE: Opening the Therapeutic Window for PSMA-Targeted Molecular Radiotherapy

STUDY_SECTION: CMIP

STUDY_SECTION_NAME: Clinical Molecular Imaging and Probe Development[CMIP]