NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Natural Products;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Stroke;Unintentional Childhood Injury

ORG_CITY: MILWAUKEE

ORG_DEPT: PEDIATRICS

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Acute kidney injury is a significant complication for infants who experience hypoxic ischemic encephalopathy, being associated with increased rates of death and prolonged hospitalization. Our pilot study of theophylline administration soon after birth for the prevention of kidney injury will lay the foundation for the conduct of a larger clinical trial that seeks to identify a theophylline as a novel therapy to prevent kidney injury in thousands of at-risk infants.

PI_NAMEs: SEGAR, JEFFREY L (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Adherence;Adverse effects;Age Years;Aminophylline;Asphyxia Neonatorum;Attenuated;Biological Markers;Birth;Blood flow;Cessation of life;Chronic Kidney Failure;Clinical Data;Clinical Trials;clinically relevant;Complex;Complication;Creatinine;Data;Data Analyses;Data Collection;Death Rate;Development;Diagnosis;Disease;Dose;Drug Kinetics;Effectiveness;Enrollment;Ensure;Evaluation;experience;extracellular vesicles;FDA approved;Feasibility Studies;Fluid Balance;Foundations;Functional disorder;Future;Goals;Health;Hospitalization;Hour;Hyperglycemia;Hypertension;Hypoxia;improved;Incidence;Infant;Injury;Injury to Kidney;Intervention;Intervention Studies;Intravenous;Kidney;Life;Literature;Measures;Mechanical ventilation;Methods;Mission;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;National Institute of Diabetes and Digestive and Kidney Diseases;natural hypothermia;Neonatal;neonatal hypoxic-ischemic brain injury;neonate;Nephrons;Neurological outcome;novel;novel marker;novel therapeutics;Organ;Outcome;Output;Oxygen;Patients;Pharmacodynamics;Pilot Projects;Placebos;Population;Predisposition;Pregnancy;prevent;Prevention;primary outcome;Procedures;Process;Prophylactic treatment;Protocols documentation;Publishing;randomized trial;recruit;Regimen;Renal function;renal hypoxia;Reporting;Research;response;Risk;Safety;Sampling;Seizures;Serum;Severities;standard of care;Tachycardia;targeted treatment;Telephone;Testing;Theophylline;Therapeutic;Therapeutic Trials;Tubular formation;Urine

PROJECT_TITLE: Theophylline Prophylaxis during Hypothermia to Limit Neonatal Nephron Damage

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The proposed research is relevant to public health because it will focus on functional heterogeneity of dopamine system, which plays critical roles in our ability of learning and memory as well as a variety of diseases including Parkinson’s and schizophrenia. Completion of the project will provide novel molecular insights into the functional diversity of dopaminergic neurons and circuit mechanisms of integrating output signals from heterogeneous dopamine circuitry.

PI_NAMEs: HIGE, TOSHIHIDE  (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TITLE: Molecular and circuit mechanisms of learning supported by heterogeneous dopaminergic neurons

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Disability Research;Pain Research;Pediatric;Prevention

ORG_CITY: JACKSONVILLE

ORG_NAME: NEMOURS CHILDREN'S CLINIC

ORG_STATE: FL

PHR: PROJECT NARRATIVE Chronic musculoskeletal (MSK) pain is a major health concern in late adolescents and young adults (AYAs) that is associated with significant functional disability, psychosocial impairment, and unique challenges during the transition to adulthood. Approaches to mitigate maladaptive pain-related outcomes and enhance protective factors that promote healthy adaptation to pain (e.g., resilience) during this vulnerable developmental stage of life are limited, but of critical importance. The proposed work will elucidate resilience factors across multiple domains of functioning in late AYAs with and without chronic MSK pain, explore how these factors are associated with improved pain, disability, and pain modulatory capacity over time in youth with chronic MSK pain, and inform the development of prevention and intervention strategies for improved pain management in this population.

PI_NAMEs: PALIT, SHREELA  (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Achievement;Address;Adolescence;Adolescent;Adolescent and Young Adult;Adult;Affect;Age;Biological;Biometry;biopsychosocial;Body mass index;Cardiovascular system;career development;Characteristics;Childhood;Chronic low back pain;chronic musculoskeletal pain;chronic pain;Classification;clinical care;Clinical Investigator;clinical pain;clinical predictors;Clinical Research;Clinical Trials Design;comorbidity;Competence;coping;Data;Development;Development Plans;disability;Ecological momentary assessment;emerging adult;emerging adulthood;Equilibrium;Exercise;Exhibits;experience;Familiarity;Family;follow-up;forging;Fostering;functional disability;Future;Glean;Goals;Health;heart rate variability;Impairment;improved;Individual;innovation;Intervention;Investigation;K-Series Research Career Programs;Knowledge;knowledge base;Laboratories;Leadership;Life;Life Cycle Stages;Life Style;Literature;Measurable;Measurement;Measures;Mental Depression;Mentors;Mentorship;Methodology;Modeling;multidisciplinary;Musculoskeletal Pain;National Institute of Child Health and Human Development;Nature;negative affect;older adult;optimism;Outcome;Pain;Pain management;Pain Measurement;pain outcome;Participant;patient oriented;Patient Self-Report;Patient-Centered Care;Patients;peer support;Performance;Persistent pain;Personal Satisfaction;Physical Function;Play;Population;precision medicine;prevent;Prevention;Prevention strategy;Procedures;Process;Productivity;programs;promote resilience;prospective;protective factors;psychologic;Psychology;psychosocial;Quality of life;Recovery;Reporting;Research;Research Personnel;resilience;resilience factor;Resolution;response;Risk;Risk Factors;Role;Sampling;Science;Self Efficacy;skills;sleep quality;social;Source;Strategic Planning;Stress;stressor;Symptoms;Time;Training;transition to adulthood;translational scientist;treatment response;Visit;Work;young adult;Youth

PROJECT_TITLE: Study of Healthy Adaptation and Resilience to Pain in Emerging Adulthood (SHARPE)

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD(A)-1-K]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Lung;Pulmonary Fibrosis

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Idiopathic pulmonary fibrosis is a deadly lung disease of unknown cause, characterized by progressive lung tissue scarring and airflow limitation, with limited treatment options. Our proposed studies will investigate matrix-associated glycoproteins (Magps), which are highly expressed during fibrosis and appear to play an inhibitory role in the progression of the disease. We will evaluate potential mechanisms by which Magps may attenuate fibrosis, and characterize the cell populations that produce Magps, to identify exploitable pathways for IPF treatment.

PI_NAMEs: KOENITZER, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acceleration;Advisory Committees;Affinity;airway obstruction;antifibrotic treatment;ATAC-seq;Attenuated;Binding;Bioinformatics;Biology;Bleomycin;Bone Marrow;career;career development;Cell Nucleus;Cells;Characteristics;Collaborations;Compensation;cytokine;Data;Deposition;Development;Disease;Disease Progression;epigenome;epigenomics;Exhibits;experimental study;Extracellular Matrix;Family member;Fibroblasts;fibrogenesis;Fibrosis;fibrotic lung;Follow-Up Studies;Gene Expression;Gene Expression Regulation;Genes;Glycoproteins;Goals;Growth Factor;Homeostasis;Human;Hypoxia;idiopathic pulmonary fibrosis;Image;Immune;immune cell infiltrate;immune function;Immune response;improved;In Situ;in vivo;Individual;Inflammatory;Inflammatory Response Pathway;inhibitor;Injury;interest;Interstitial Lung Diseases;Knock-out;Knockout Mice;Lung;Lung Diseases;lung histology;lung injury;Lung Transplantation;Macrophage;Mediating;Mentors;Mesenchymal;MFAP1 gene;Microfibrils;Modeling;mortality;Mus;Names;novel strategies;Pathogenesis;Pathway interactions;Phase;Phenotype;Physicians;Play;Population;Process;Production;Proliferating;Protein Secretion;Proteins;Pulmonary Fibrosis;receptor;Recovery;Regulation;Reporting;Research Personnel;response;Role;Scientist;side effect;Signal Transduction;single cell sequencing;single nucleus RNA-sequencing;single-cell RNA sequencing;Specificity;Supportive care;Tissues;Training;transcriptome;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;transforming growth factor beta3;Up-Regulation;Work

PROJECT_TITLE: Microfibril-associated glycoproteins attenuating pulmonary fibrosis

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: Over one million Americans rely on their upper extremities for manual wheelchair propulsion. Shoulder overuse injuries are prevalent among manual wheelchair users and these injuries often result in shoulder pain. Severe shoulder pain can lead some wheelchair users to transition from manual to powered mobility, complicating transportation, and reducing independence in activities of daily living. This project will expand our understanding of a new wheelchair design that allows better positioning of the hand rims and allows for different gearing. We will study steady-state propulsion efficiency with different gear ratios and develop a new system with multiple gear ratios. The advanced gearing will allow for a low gear when initiating movement, going uphill, or when moving over carpet, and then a higher gear option for movements on hard flat level terrain. This system has the potential to dramatically improve shoulder ergonomics and reduce pain in many future manual wheelchair users.

PI_NAMEs: HANSEN, ANDREW H.;LOOFT, JOHN M (contact)

PROJECT_TERMS: Activities of Daily Living;American;Back;base;Carpet;commercialization;Couples;Cross-Over Studies;Cumulative Trauma Disorders;Data;design;Development;Engineering;Equilibrium;ergonomics;Feedback;Frequencies;Future;grasp;Hand;improved;Individual;individual patient;industry partner;Injury;Laboratories;Lead;Length;Licensing;Manual wheelchair;Manuals;Marketing;Measurement;Measures;meter;Movement;pain reduction;Positioning Attribute;prevent;Process;programs;recruit;Rehabilitation therapy;Risk;Shoulder;Shoulder Pain;Side;Speed;Stroke;Surface;System;Technology Transfer;Testing;Transportation;Travel;Upper Extremity;Veterans;Wheelchair propulsion;Wheelchair user;Wheelchairs;Work

PROJECT_TITLE: Multi-speed Ergonomic Wheelchair

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Approximately 800,000 Americans experience a stroke each year, including about 15,000 Veterans, with a cost of care in the hundreds of millions of dollars. After a stroke, balance deficits often limit functional mobility and increase the risk of falls, decreasing quality of life for thousands of individuals. While the role of altered sensation in these balance deficits is often acknowledged, clinical interventions tend to focus on motor function due to the difficulty of directly manipulating sensation. This project will investigate whether a novel approach to multisensory augmentation has the potential to improve standing balance in people who have experienced a stroke, as well as the extent to which personalizing the augmentation to individual participants has beneficial effects. The results of this work have the potential to motivate a new approach to balance rehabilitation, which could increase the quality of life of thousands of Veterans and save millions of dollars.

PI_NAMEs: DEAN, JESSE C. (contact)

PROJECT_TERMS: Address;Adjuvant Therapy;Affect;American;Ankle;Balance training;Basic Science;Behavior;care costs;chronic stroke;Clinical;clinically relevant;Cognitive;Cognitive deficits;Communities;Cutaneous;cutaneous sense;design;Development;Devices;Effectiveness;Equilibrium;Esthesia;Exercise;Exhibits;exoskeleton;experience;experimental study;fall risk;falls;Feedback;foot;foot sole;Foundations;Hip region structure;human-in-the-loop;improved;Incidence;Individual;individual patient;insight;Intervention;invention;Knowledge;Lateral;Methods;Motor;Movement;multisensory;Nervous System;neurophysiology;novel;novel strategies;older adult;Participant;Patients;Pattern;Performance;Persons;Population;post stroke;prevent;Probability;Proprioception;Quality of life;Randomized, Controlled Trials;Rehabilitation therapy;relative effectiveness;Research;Role;Self-Help Devices;sensor;Sensory;sensory feedback;somatosensory;Source;Stimulus;Stroke;success;Tactile;tool;Training;Translating;Vestibular dysfunction;Veterans;Work

PROJECT_TITLE: Multisensory augmentation to improve the standing balance of people with chronic stroke


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebral Palsy;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Rehabilitation

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because cerebral palsy (CP) is the most common cause of physical disability in children. Physical disability in CP is caused by the failure to learn or refine motor control during the first two years of life, yet very little is known about how infants and toddlers with CP learn (or fail to learn) to move. This project is relevant to the missions of NICHD and NCMRR because characterizing the longitudinal evolution of locomotor learning in infants with CP will inform the development of rehabilitative treatments that increase the chance for these children to achieve their full potential and lead a healthy and productive life free from disability.

PI_NAMEs: PROSSER, LAURA ANNE (contact);SHIH, YO ;SMITH, BETH A

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Adult;Age Months;Behavior;behavior observation;Biomechanics;Brain;Caring;Cerebral Palsy;Characteristics;Child;Cognition;comparative efficacy;Complex;computer science;critical period;Data;Dependence;design;Development;disability;Disease;efficacy study;Enrollment;Ensure;Environment;Equilibrium;evidence base;Evolution;experience;Failure;Funding;Future;Goals;Health;high risk;Human;Impairment;improved;Individual;infancy;Infant;Lead;Learning;learning strategy;Leg;Life;life span;Link;Locomotion;Locomotor training;longitudinal design;Longitudinal Studies;Measures;Mediating;Mediator;Mission;Mobility decline;Modeling;Motivation;Motor;motor control;Motor disability;motor learning;Motor Skills;Movement;Multi-Institutional Clinical Trial;Musculoskeletal Equilibrium;National Institute of Child Health and Human Development;Neonatology;Nervous System Disorder;neurobehavioral;Neuronal Plasticity;novel;Pattern;peer;Personal Satisfaction;Persons;physically handicapped;Pilot Projects;Population;predictive modeling;Productivity;Protocols documentation;Psychological reinforcement;Psychological Transfer;Public Health;Rehabilitation therapy;Research;Rewards;Risk;Robotics;Role;sensor technology;Shapes;Site;skill acquisition;skills;Societies;Technology;Time;time use;Toddler;Training;Travel;walker;Walking;wearable sensor technology;Work

PROJECT_TITLE: Locomotor learning in infants at high risk for cerebral palsy

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Idiopathic Pulmonary Fibrosis (IPF) is a deadly disease, affecting 89,000 people in the United States, for which there is no cure. We have found that changes in the metabolism in lung fibroblasts significantly contributes to fibrosis (scar formation) in the lungs. We aim to identify mechanisms by which metabolism is regulated in lung fibroblasts and mechanisms by which altered metabolism contributes to fibrosis.

PI_NAMEs: HAMANAKA, ROBERT BRIAN (contact)

PROJECT_TERMS: 3-phosphoglycerate;activating transcription factor;activating transcription factor 4;Affect;Alleles;amino acid metabolism;Amino Acids;Biology;Carbon;Cell secretion;Cells;Characteristics;Cicatrix;Collagen;cytokine;Development;Disease;DNA Methylation;enzyme pathway;Enzymes;Epigenetic Process;epigenome;epigenomics;experimental study;Extracellular Matrix;Fibroblasts;fibrogenesis;Fibrosis;FRAP1 gene;Genetic;Genetic Transcription;Glucose;Glycine;Glycolysis;Goals;Homeostasis;Human;idiopathic pulmonary fibrosis;Impairment;In Vitro;in vivo;indium-bleomycin;knock-down;Knock-in;Link;LoxP-flanked allele;Lung;Mediating;Metabolic;metabolic abnormality assessment;Metabolic Pathway;Metabolism;Methionine;Methylation;Modeling;mTOR Signaling Pathway;Mus;Myofibroblast;novel;overexpression;Pathogenesis;Pathway interactions;Persons;Phenotype;Play;Production;Protein Biosynthesis;Proteins;Pulmonary Fibrosis;pulmonary function;Reaction;Regulation;Ribosomal Protein S6 Kinase;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Serine;Signal Transduction;Testing;Therapeutic;therapeutic target;Transforming Growth Factor beta;treatment strategy;United States;Up-Regulation

PROJECT_TITLE: Metabolic Regulation of Myofibroblast Differentiation

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric

PHR: PROJECT NARRATIVE This project develops novel tools for measuring nonverbal social communication as manifested through facial and bodily expressions. Using advanced computer vision and machine learning methodologies, we will quantify humans’ communicative social behavior. The results of this project will impact public health by facilitating a rich characterization of normative development of social functioning, providing access to precise phenotypic information for neuroscience and genetics studies, and by measuring subtle individual differences to determine whether some interventions or treatments work better than others.

PI_NAMEs: TUNC, BIRKAN  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Adolescent;Age;analysis pipeline;Area;Autism Diagnosis;autism spectrum disorder;automated algorithm;Behavior;behavior measurement;Behavioral;behavioral health;Behavioral Research;Behavioral Sciences;Body measure procedure;Characteristics;Child;Classification;Clinical;clinical application;Code;Communication;Community Health;Complex;Computational Technique;Computer Analysis;Computer Vision Systems;computerized tools;Cues;Data;Democracy;design;Development;Diagnostic;Dimensions;Disease;Educational Materials;Engineering;Face;Facial Expression;Genetic study;Goals;Grain;Grant;Human;Individual;Individual Differences;individual variation;interest;Intervention;Joints;kinematics;Literature;Machine Learning;machine learning method;Measurement;Measures;Mental Health;Methods;Motion;Movement;Nature;Neurologic;Neurosciences;non-verbal;Nonverbal Communication;novel;open source;Oral cavity;Participant;Perception;Performance;Persons;Phenotype;Population Heterogeneity;Production;Public Health;Publishing;Reproducibility;Research;Research Personnel;Sampling;Science;Scientist;sex;Sex Differences;Social Behavior;social communication;Social Development;Social Environment;Social Functioning;Social Interaction;Speech;System;Techniques;Teenagers;Time;tool;Training;Translations;usability;Validation;Work;young adult

PROJECT_TITLE: A computer vision toolbox for computational analysis of nonverbal social communication

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition

ORG_CITY: SHREVEPORT

ORG_DEPT: PATHOLOGY

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: PROJECT NARRATIVE There is an urgent clinical need to identify new therapeutic approaches to simultaneously treat non-alcoholic fatty liver disease and atherosclerosis, which often manifest together. We uncovered the N-acyl amino acid metabolism, linking lipid and amino acid metabolism, as a common pathway dysregulated in both diseases, creating a new point for concurrent intervention. We will study its role and underlying metabolic mechanisms and will evaluate an intervention based on N-acyl amino acids, with the ultimate objective of accelerating development of a novel therapy for the simultaneous treatment of these two prominent diseases.

PI_NAMEs: ROM, OREN SHALOM (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Acceleration;Acids;Address;Advanced Development;Affect;Amides;amino acid metabolism;Amino Acids;Arterial Fatty Streak;Atherosclerosis;Attention;Automobile Driving;Biological Assay;Cardiometabolic Disease;cardiometabolic risk;Cardiovascular Diseases;Cardiovascular system;Cause of Death;chemokine;Chronic;chronic liver disease;Clinical;Data;Dependence;Development;Diet;dietary;Disease;drug candidate;drug development;Dyslipidemias;Energy Metabolism;Enzymes;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;Fatty Liver;Fibrosis;gain of function;Genes;Genetic;Genetic Transcription;genetic variant;genome wide association study;genome-wide;Healthcare Systems;Hepatic;Hepatocyte;hepatocyte injury;Histologic;Human;In Vitro;in vivo;in vivo Model;indexing;Individual;Inflammation;Inflammatory;Intervention;Leucine;Ligands;Link;lipid metabolism;Lipids;Liver;Liver Fibrosis;Lobular;long chain fatty acid;loss of function;Luciferases;Macrophage;Mediating;Metabolic;Metabolic Pathway;metabolomics;Modeling;monocyte;mortality;mouse model;Mouse Strains;Mus;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;novel therapeutic intervention;novel therapeutics;Obesity;overexpression;Pathway interactions;Patients;pharmacologic;Population;PPAR alpha;PTGS1 gene;PTGS2 gene;recruit;Regulation;Risk;Risk Factors;Role;Sampling;Signal Pathway;Signaling Molecule;Testing;Tissues;transcriptomics;Up-Regulation;Variant;Weight Gain;Work

PROJECT_TITLE: Lipidated Amino Acids in Cardiometabolic Diseases

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE  Individuals with diabetes are at higher risk of developing critical limb ischemia (CLI), which occurs due to excessive atherosclerosis in the lower extremities and can lead to surgical complications such as amputation. There are currently no tailored therapies to prevent such complications in surgical patients with diabetes and CLI. Our group discovered that targeting a biochemical process responsible for generating lipid molecules in the peripheral arterial system may be a viable target for future tailored therapies for patients with diabetes and CLI. In this proposal we will test this in mouse models that have diabetes and are prone to developing peripheral arterial occlusive disease.

PI_NAMEs: ZAYED, MOHAMED A. (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Acceleration;Adoption;Adult;Affect;Agonist;Amputation;Arterial Intimas;Arterial Occlusive Diseases;Atherosclerosis;base;Biochemical;Biochemical Process;Blood Vessels;burden of illness;Cardiac;Cell Physiology;cell type;Choline;Chronic Disease;Clinical;Clinical Data;Clinical Management;Clinical Trials;Complement;conditional knockout;cost;critical limb Ischemia;Data;Diabetes Mellitus;diabetes pathogenesis;Diet;Diffuse Pattern;Disease;Disease Progression;double-blind placebo controlled trial;effective therapy;Endothelial Cells;Endothelium;Enzymes;Ethanolamines;Event;FASN gene;Fatty Acids;Fatty-acid synthase;Fenofibrate;Financial Hardship;Functional disorder;Future;Genes;Health;high risk;Homeostasis;improved;Individual;individualized medicine;innovation;insight;Insulin Resistance;Intervention;Intervention Studies;Investigation;Isolated limb perfusion;Knock-out;Knowledge;lipid biosynthesis;lipid metabolism;Lipid Synthesis Pathway;Lipids;Low-Density Lipoproteins;Lower Extremity;Mediating;Membrane;Metabolic;Molecular;Morbidity - disease rate;mouse model;Mus;novel;Operative Surgical Procedures;Organ;Outcome;Patients;Peripheral;Peripheral arterial disease;Persons;Pharmaceutical Preparations;pharmacologic;Phospholipids;Phosphotransferases;Play;Post-Translational Protein Processing;PPAR alpha;Prevalence;prevent;Prevention strategy;Process;Protocols documentation;psychologic;Reagent;Regulation;Research;revascularization surgery;Risk;Role;Serum;Signal Transduction;Smooth Muscle Myocytes;Surgical complication;Surgical Management;System;targeted treatment;Techniques;Testing;Tissues;translational potential;treatment strategy;Triglycerides;United States

PROJECT_TITLE: Regulation of Endothelial Lipid Metabolism in the Setting of Diabetes and Critical Limb Ischemia to Prevent Surgical Complications

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Nutrition;Obesity;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: BIOLOGY

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: The goal of this project is to study the role of HDAC1 as a nutrient sensor that regulates hepatic lipid metabolism and inflammation in the development and progression of NAFLD in response to excess nutrients. Completion of this project will help guide the development of the epigenetic enzyme HDAC1 as a therapeutic target in the prevention and treatment of non-alcoholic fatty liver disease.

PI_NAMEs: SHI, HANG  (contact);YU, LIQING

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Address;Affect;ATAC-seq;Chemotaxis;Chromatin;Cirrhosis;Complex;Cues;Cytoplasmic Protein;Data;Development;Diet;Disease;Down-Regulation;driving force;Environment;Environmental Risk Factor;Enzymes;Epigenetic Process;epigenetic regulation;epigenome;Evaluation;Event;Family;Family member;Fatty Acids;Fatty Liver;feeding;fibrogenesis;Fibrosis;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Models;genome wide association study;Glucose;Goals;HDAC1 gene;Hepatic;High Fat Diet;Histone Acetylation;Histone Deacetylase;Histone Deacetylase Inhibitor;Histones;Individual;Inflammation;Insulin Resistance;JUN gene;Lead;Link;lipid biosynthesis;lipid metabolism;Lipids;Liver;liver development;Liver Failure;liver inflammation;Location;Lysine;Malignant neoplasm of liver;Mediating;member;Meta-Analysis;Metabolic Diseases;Metabolic Pathway;Molecular;mRNA Expression;Mus;Names;new therapeutic target;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;Nuclear Protein;Nutrient;Nutritional;Obesity;overexpression;Pathologic;Play;Post-Translational Protein Processing;PPAR gamma;prevent;Prevention;Process;programs;promoter;Proteins;Regulation;Reporting;Resistance;response;Risk Factors;Role;Saturated Fatty Acids;Secondary to;sensor;Susceptibility Gene;therapeutic target;transcription factor;Transcription Repressor;transcriptome sequencing;Triglycerides;Ubiquitination;Up-Regulation;Weight

PROJECT_TITLE: HDAC1 as a nutrient sensor in the development and progression of NAFLD

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Biotechnology;Genetics;Kidney Disease

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative Patients requiring cardiac or vascular surgery often have brief reductions in blood flow to the kidneys, which unfortunately can result in kidney injury, decreased kidney function, development of chronic kidney disease, and/or death. In this setting, kidney histone deacetylase enzymes and mircoRNA are activated and may lead to excessive scarring in the kidney. The purpose of this proposal is to determine the epigenetic regulation of myofibroblast activation following kidney injury leading to chronic kidney disease transition.

PI_NAMEs: HYNDMAN, KELLY  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Adverse event;Atrophic;Attenuated;attenuation;beta catenin;Bilateral;Blood flow;Blood Vessels;Cardiac;Cell Nucleus;cell type;Cells;Cessation of life;Chromatin;Chronic;Chronic Kidney Failure;Cicatrix;Coupled;Data;Development;differential expression;Disease Progression;Electrolytes;Endothelial Cells;Endothelium;Enzymes;Epigenetic Process;epigenetic regulation;Epithelial Cells;epithelial repair;Epithelium;experimental study;Fibroblasts;Fibrosis;Fostering;Genes;glomerulosclerosis;HDAC1 gene;healing;Histone Deacetylase;Histone Deacetylase Inhibitor;hypoperfusion;Immune;In Vitro;in vivo;Injury;Injury to Kidney;interstitial;interstitial cell;Kidney;kidney cell;kidney cortex;Kidney Diseases;kidney fibrosis;knock-down;Knock-out;Knockout Mice;Knowledge;Liquid substance;Mediating;MicroRNAs;Modeling;Modification;Molecular;mouse model;Myofibroblast;novel;novel therapeutic intervention;Operative Surgical Procedures;Outcome;Pathologic;Pathway interactions;Patients;Pattern;Pericytes;prevent;Protein Isoforms;Proteins;Publishing;Renal function;repaired;Reperfusion Injury;response;Risk;Signal Pathway;Signal Transduction;Source;Structure of glomerular mesangium;Testing;TGFB1 gene;Therapeutic;transcriptome sequencing;transcriptomics;Tubular formation;Up-Regulation;Ureteral obstruction

PROJECT_TITLE: Epigenetic Regulation of Kidney Fibrosis following AKI


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE This project will assess how cortical feedback modulates the activity and sensory processing in the cortex. Cortical feedback pathways are thought to mediate cognitive processes such as attention, prediction, expectation, and awareness. Altered feedback communication has also been associated with certain neuropsychiatric disorders, so the results of this project will provide fundamental knowledge about the brain that may help reduce the burden of disease.

PI_NAMEs: CRANDALL, SHANE R (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Address;Anatomy;Area;Attention;autism spectrum disorder;Awareness;Brain;burden of illness;Cells;Characteristics;cognitive process;Color;Communication;Consensus;Cre driver;Data;Electrophysiology (science);Epilepsy;Equilibrium;Esthesia;Exhibits;expectation;Feedback;Feeds;Genetic;Glutamates;Goals;In Vitro;in vivo;information processing;inhibitory neuron;insight;Investigation;Kinetics;Knowledge;Mediating;Motor;motor behavior;motor control;Motor Cortex;Mus;neglect;Neocortex;Nervous System Disorder;neural circuit;neuronal excitability;Neurons;neuropsychiatric disorder;Optics;optogenetics;Output;Pathway interactions;Pattern;Peripheral;Physiological;Play;Population;Preparation;Property;Prosencephalon;Pyramidal Cells;recruit;Role;Schizophrenia;sensorimotor system;Sensory;sensory cortex;sensory system;Shapes;Signal Transduction;Somatosensory Cortex;Source;Study models;Synapses;Synaptic Transmission;System;Techniques;Testing;Thalamic structure;tool

PROJECT_TITLE: Dynamic properties of neural circuits in the forebrain

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Diabetes

ORG_CITY: St. Louis

ORG_DEPT: PHARMACOLOGY

ORG_NAME: ST. LOUIS COLLEGE OF PHARMACY

PHR: Project Narrative Activation of estrogen-related receptor α (ERRα) is an emerging therapeutic approach for treating Diabetes and metabolic diseases. This proposal will study ligand binding dynamics and perform large-scale virtual screening for the discovery of specific agonists of ERRα.

PI_NAMEs: HEGAZY, LAMEES  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Agonist;Allosteric Site;Anti-Inflammatory Agents;Applications Grants;Binding;Binding Sites;Biogenesis;Biological Assay;Blindness;Cells;Cessation of life;Characteristics;Chemicals;Collaborations;Complex;computer studies;Computers;Data;design;Diabetes Mellitus;Docking;Drug Design;drug-like compound;ERR1 protein;experimental group;fatty acid metabolism;Foundations;Free Energy;Future;Gene Expression;in vivo;insight;interest;Investigation;Ligand Binding;Ligands;limb amputation;Lower Extremity;Metabolic Diseases;Metabolic syndrome;Methods;Molecular;Molecular Conformation;molecular dynamics;molecular modeling;Mutagenesis;Myocardial Infarction;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear Hormone Receptors;Oxidative Phosphorylation;Patients;pharmacologic;Phase;Property;Protein Isoforms;Proteins;Radio;rational design;Receptor Activation;Reporting;Research Project Grants;Resolution;Roentgen Rays;Role;scaffold;Shapes;Signal Transduction;simulation;Site;small molecule;small molecule libraries;Structure;Surface;Therapeutic;therapeutic target;tool;Validation;virtual;virtual screening;Work;World Health Organization

PROJECT_TITLE: Investigation and Targeting of Alternate Binding Site in ERRα

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P(54)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Lewy Body Dementia;Lymphatic Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Physical Activity;Physical Rehabilitation;Rehabilitation;Sleep Research

ORG_CITY: Aurora

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Persons with Parkinson’s disease (PwP) frequently experience cognitive dysfunction, which has a profound negative impact on quality of life and daily function and thus increases public health burden. Pharmacologic therapies are often ineffective for treating cognitive dysfunction in Parkinson’s disease and no medications are known to halt cognitive decline. This study will investigate deep sleep as a marker of rehabilitation-induced improvement in cognition in Parkinson’s disease to guide selection of the optimal exercise prescription for individual PwP.

PI_NAMEs: AMARA, AMY WILLIS (contact)

PROJECT_TERMS: Address;Adult;Affect;Amyloid beta-Protein;Area;arm;Biological Markers;Blood Vessels;Brain;Caregiver Burden;Cognition;Cognitive;cognitive function;cognitive impairment in Parkinson's;cognitive performance;common symptom;daily functioning;Data;design;Diffusion Magnetic Resonance Imaging;disabling symptom;Disease;executive function;Exercise;exercise prescription;exercise rehabilitation;experience;glymphatic clearance;glymphatic function;glymphatic system;Heterogeneity;Impaired cognition;Impairment;improved;Individual;individual response;innovation;Institutionalization;Intervention;Lewy Bodies;Lewy Body Dementia;Link;Measures;Mediating;Mediation;Mediator;mild cognitive impairment;mode of exercise;Mus;Nature;Neurodegenerative Disorders;Neurotoxins;non-motor symptom;novel;novel marker;Outcome;Parkinson Disease;Parkinson's Dementia;Participant;Pathology;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phase;Phenotype;physical impairment;Polysomnography;prevent;primary outcome;Productivity;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;rehabilitation strategy;Rehabilitation therapy;Reproducibility;Research Design;Resistance;resistance exercise;response;Risk;Sequential Multiple Assignment Randomized Trial;Sleep;Slow-Wave Sleep;Source;Structure;Synaptic plasticity;Techniques;Testing;Time;Training;treatment response;trial design;United States National Institutes of Health;week trial;Work

PROJECT_TITLE: Slow wave sleep as a biomarker of rehabilitation-induced cognitive improvement in Parkinson's disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: WORCESTER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative: This project seeks to describe the basic principles that govern maternal RNA recognition and regulation in early development. Analysis of how post-transcriptional regulatory mechanisms, and more broadly how maternally supplied proteins and mRNAs, contribute to cell fate specification events in early development will ultimately lead to a better understanding of how developmental processes fail in disease. This project focuses on regulation mediated by the 3’UTR of maternal RNAs, and includes a variety of experiments to establish which regulatory events are most important for reproductive health, and how regulation works at a mechanistic level.

PI_NAMEs: RYDER, SEAN PATRICK (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 3' Untranslated Regions;Address;Affinity;Alleles;Amino Acids;Animals;Atmosphere;Binding;Binding Sites;Biochemical;Biological;Biological Assay;Biology;Caenorhabditis elegans;candidate identification;cell fate specification;Cells;Child;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Coupled;CRISPR/Cas technology;Critical Pathways;Data;Databases;Development;Developmental Process;Disease;Elements;Embryo;Embryonic Development;Engineering;Ensure;Event;experimental study;Fertilization;gene replacement;Genes;Genetic;Genetic Screening;Genome;genome editing;Germ Lines;In Vitro;in vivo;Individual;innovation;Instruction;interdisciplinary approach;interest;Invertebrates;Learning;Mammals;Maps;Maternal Messenger RNA;Mediating;medical schools;Meiosis;Messenger RNA;Molecular;mRNA Expression;Mutagenesis;mutant;Mutate;Mutation;Nature;Nematoda;oocyte maturation;Oogenesis;Outcome;Parents;Pattern;Pattern Formation;Phenotype;Physiological;Play;Positioning Attribute;Post-Transcriptional Regulation;posttranscriptional;Property;Proteins;Regulation;Regulatory Element;Reporter;Reporter Genes;Reproduction;reproductive;Reproductive Health;Research;RNA;RNA Binding;RNA interference screen;RNA-Binding Proteins;Role;Series;Sexual Reproduction;Site;Specificity;Sterility;stoichiometry;Technology;temporal measurement;Testing;Time;tool;Transcript;Transgenes;Transgenic Organisms;Translating;unpublished works;Untranslated Regions;Work;zygote

PROJECT_TITLE: Post-transcriptional regulation of germline mRNAs in C. elegans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGB-P(07)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: LEXINGTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE This project seeks to examine whether innovative local tobacco control policies restricting sales of flavored tobacco products can reduce tobacco use and disparities in tobacco and, ultimately cancer. The study will examine trajectories of flavored tobacco use in a large longitudinal national cohort of youth and young adults among those exposed and not exposed to policy. It will also examine youth and young adult non-tobacco user exposure to tobacco marketing and subsequent tobacco use outcomes in real-time in eight communities with different flavor policy variants and will have a particular focus on assessing differences in policy impact across vulnerable group status.

PI_NAMEs: ROSE, SHYANIKA W (contact)

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: Address;Advertising;Affect;Area;attributable mortality;California;cancer health disparity;cancer risk;Cigarette;cigarette smoking;cigarillos;Code;cohort;Communities;cost;County;Data;Data Collection;Data Set;Databases;demographics;Disparity;disparity reduction;Ecological momentary assessment;Education;Electronic cigarette;emerging adult;Ensure;Equity;Ethnic Origin;evidence base;Exposure to;follow-up;Goals;health disparity;health equity;Home;implementation framework;Income;Individual;innovation;Kentucky;Laws;Link;Longitudinal cohort;Longitudinal trends;Low income;low socioeconomic status;Malignant neoplasm of lung;Malignant Neoplasms;Marketing;Menthol;Modeling;neighborhood disadvantage;Neighborhoods;Outcome;Participant;people of color;Persuasive Communication;Policies;Population;Protocols documentation;Public Policy;public policy on tobacco;Race;racial difference;Reduce health disparities;reduce tobacco use;Research;Resources;Respondent;Risk;Sales;Smokeless Tobacco;Socioeconomic Status;Statistical Data Interpretation;Structure;Testing;theories;Time;Tobacco;tobacco advertising;tobacco exposure;tobacco flavor;tobacco products;Tobacco use;tobacco user;trend;United States Food and Drug Administration;Universities;Variant;vulnerable community;Vulnerable Populations;young adult;Youth

PROJECT_TITLE: Local Flavor Policies to Enhance Equity in Tobacco


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Immunization;Immunotherapy;Infectious Diseases;Lung;Pediatric;Pneumonia;Pneumonia and Influenza

ORG_CITY: Morrisville

ORG_NAME: MUCOMMUNE, LLC

PHR: Project Narrative There are no vaccines or treatments available for either respiratory syncytial virus (RSV) or metapneumovirus (MPV), two of the leading causes of bronchiolitis in young children, immunocompromised adults and the elderly, which collectively results in millions of infections and tens of thousands of hospitalizations each year in the U.S alone. To meet the urgent need for a treatment for both, Mucommune is developing MM-004, a muco- trapping bispecific monoclonal antibody against both RSV and MPV that can quickly clear both viruses from infected lungs. Building off of our promising data against RSV in lambs, this FastTrack proposal will first demonstrate in vivo proof-of-concept efficacy in a hamster model of MPV infections in Phase 1, followed by development of cGMP-compliant cell lines and IND-enabling studies in Phase 2.

PI_NAMEs: CONE, RICHARD  (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: Address;Adsorption;Adult;aerosolized;Affinity;Aftercare;Animals;Antibody Therapy;Antigens;antiviral drug development;Attention;Back;Binding;Biological Assay;Bispecific Monoclonal Antibodies;Bronchiolitis;Cause of Death;cell bank;Cell Line;Cells;Cessation of life;Characteristics;Child;Childhood;Clinic;Clinical;clinical development;cost;cost effective treatment;Critical Pathways;cross reactivity;Cyclic GMP;Data;Daughter;Development;Dose;effective therapy;efficacy evaluation;Elderly;Engineering;Ensure;FDA approved;Hamsters;high risk infant;Hospitalization;Human;Immunocompromised Host;immunoprophylaxis;Immunotherapy;improved;In Vitro;in vivo;Infant Mortality;Infection;Infection prevention;Inflammation;Inhalation;Intercept;Intervention;Intramuscular Injections;Lung;Metapneumovirus;Modality;Modeling;Molecular Target;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mucins;Mucous body substance;mucus clearance;Mus;Nebulizer;necrotic tissue;Neonatal;Neutrophil Infiltration;Palivizumab;Pathologic;Patients;pharmacologic;Phase;Pneumonia;Positioning Attribute;pre-clinical;pre-Investigational New Drug meeting;Production;programs;purge;Rattus;Research;research and development;respiratory;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Tract Infections;Risk;Safety;side effect;single molecule;Site;Small Business Innovation Research Grant;Structure of parenchyma of lung;success;Supportive care;Therapeutic;Tissues;Topical application;Vaccine Therapy;Vaccines;Validation;vibration;Viral;Viral Load result;Viremia;Virus;Virus Shedding;Work

PROJECT_TITLE: SBIR: In vivo validation and IND-enabling development of MM004, a bispecific inhaled immunotherapy for RSV and MPV

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-R(12)B]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Alzheimer’s disease (AD) is an incurable neurodegenerative disease that progressively destroys patients’ cogni- tive functions causing enormous social and economical impact. With its underlying cause poorly understood, new imaging technologies are in demand to provide more comprehensive etiological investigation of AD over large-scale complex nervous systems, such as whole brains. In this proposal, to address this unmet need, we are to develop advanced optical imaging tools that can enable 3D brain-wide visualization of AD pathology.

PI_NAMEs: REN, JIAN  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: 3-Dimensional;Address;Affect;Algorithms;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Animals;Area;Axon;Big Data;Biochemistry;Biological;Biological Sciences;Brain;Brain imaging;Brain region;career development;Cells;Chemistry;cognitive function;Cohort Studies;Communities;Complex;computerized tools;contrast imaging;Contrast Media;Data;data acquisition;Data Analyses;Detection;Disease;economic impact;Electron Microscopy;Engineering;Environment;Etiology;General Hospitals;Goals;Graph;Histologic;Histopathology;Image;Image Analysis;image processing;imaging approach;imaging capabilities;Imaging Device;imaging modality;imaging system;Imaging technology;Impaired cognition;improved;Individual;innovation;Institution;Intervention;Investigation;Label;Light;light microscopy;Magnetic Resonance Imaging;Maps;Massachusetts;Measurement;Mentors;Methods;Microscope;Microscopic;microscopic imaging;Molecular;mouse model;multidisciplinary;Mus;nanomedicine;nanoscale;Neighborhoods;Nervous System;Neurodegenerative Disorders;Neurology;Neurosciences;optical imaging;Optics;optogenetics;Outcome;Pathologic;Pathology;Patients;PET/CT scan;physical science;Process;Progressive Disease;Property;Proteins;PUVA Photochemotherapy;reconstruction;Research;research facility;Research Personnel;Resolution;response;Sampling;Scientist;signal processing;skill acquisition;Social Impacts;Software Engineering;Specificity;stem;Structure;System;Techniques;Testing;Thick;three-dimensional visualization;Time;Tissue Engineering;tissue processing;Tissues;tomography;tool;tractography;Training;Universities;Visualization;Work

PROJECT_TITLE: High-throughput optical investigation into intact large-scale nervous systems for Alzheimers disease

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Natural Products;Women's Health Research

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Often cancer cells are “addicted” to specific DNA repair pathways to support rapid cell proliferation and resistance to radiation and DNA-damaging chemotherapeutics. DNA repair mechanisms, which cancer cells depend on to a much greater extent than normal cells, offer targeting opportunities for discovery of new effective therapeutic agents. The vast chemical space afforded by natural products will allow us to generate leads that will be employed to develop specific and non-toxic inhibitors of key DNA repair proteins RAD52 and RAD51 whose activities many cancers depend on.

PI_NAMEs: SPIES, MARIA  (contact);SPIES, MICHAEL ASHLEY

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: Ablation;Affect;Affinity;Antineoplastic Agents;Binding;Binding Proteins;Biochemical;Biological Assay;Biophysics;BRCA1 gene;BRCA2 gene;cancer cell;cancer therapy;Cancerous;Cell Physiology;Cell Proliferation;Cells;Chemicals;Chemoresistance;Chemotherapy and/or radiation;Collaborations;Collection;Crude Extracts;cytotoxic;Defect;Dependence;Disease Progression;DNA Binding;DNA biosynthesis;DNA Damage;DNA Groove Binding;DNA Maintenance;DNA Repair;DNA Repair Gene;DNA Repair Inhibition;DNA Repair Pathway;Docking;drug discovery;Drug resistance;Drug Targeting;Evolution;Fingerprint;flexibility;Fluorescence Resonance Energy Transfer;Fractionation;Future;Genetic Recombination;Genetic Variation;Genome;Genome Stability;Genomic Instability;Goals;high throughput screening;homologous recombination;Human;Hybrids;in silico;inhibitor;Learning;Libraries;Ligands;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;marine;microbial;Molecular Target;Monitor;monomer;Moon;Natural product discovery;Natural Products;Normal Cell;Organism;overexpression;PALB2 gene;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;pharmacophore;Plants;programs;Proteins;Publishing;Rad51 recombinase;RAD52 gene;Radiation induced damage;radiation resistance;repaired;replication factor A;Resistance;Resistance development;scaffold;screening;Single-Stranded DNA;Site;small molecule;Source;Specificity;Structure;Structure-Activity Relationship;Therapeutic;Therapeutic Agents;therapeutically effective;tool;Translating;Treatment-related toxicity;tumor progression;Tumor Suppressor Proteins;tumorigenesis;Validation;Water;Work

PROJECT_TITLE: Natural products inhibitors targeting homology-directed DNA repair for cancer therapy


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;HIV/AIDS;Infectious Diseases;Microbiome;Sexually Transmitted Infections;Topical Microbicides;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Dr. Michelle C. Sabo [MD, PhD] is an Acting Instructor/Senior Fellow in the Department of Medicine, Division of Allergy and Infectious Diseases, at the University of Washington. For this K23 award, she aims to evaluate the relationship between vaginal microbiota and cervical immune cells in female sex workers in Mombasa, Kenya, which has the potential to provide a mechanistic link between bacterial vaginosis and HIV acquisition risk. This research is combined with a career development plan focused on six key learning objectives, including epidemiology, clinical studies, global health, high dimensional data analysis, mucosal immunology, and the vaginal microbiome, which will provide Dr. Sabo with the additional training, experience, and mentorship she requires to become an independent physician scientist.

PI_NAMEs: SABO, MICHELLE CATHERINE (contact)

PROGRAM_OFFICER_NAME: DEYAMPERT, TARA LYNN

PROJECT_TERMS: Africa South of the Sahara;Anaerobic Bacteria;Antigen-Presenting Cells;Applications Grants;Bacteria;bacterial community;Bacterial Vaginosis;Basic Science;Biopsy Specimen;career;career development;CD4 Positive T Lymphocytes;Cell Count;Cell Separation;Cell surface;cell type;Cells;Cellular Morphology;Cervical;cervical biopsy;cervicovaginal;Cervix Uteri;Clinical;Clinical Research;Cohort Studies;Collecting Cell;Communicable Diseases;Cross-Sectional Studies;cytokine;Data;Data Analyses;Dendritic cell activation;Dendritic Cells;Development Plans;Disease;Doctor of Philosophy;Enrollment;Environment;Epidemiology;experience;female sex worker;Flow Cytometry;Gemella;Genes;Genitalia;global health;Goals;Health;high risk;high risk population;High-Throughput Nucleotide Sequencing;HIV;HIV Infections;Hypersensitivity;Immune;Immune system;Immunohistochemistry;Immunology;indexing;Infection;Inflammation;Inflammatory;insight;instructor;interest;International;Kenya;Lactobacillus;Lead;Learning;Leptotrichia;Link;Location;Measurement;Measures;Mediating;Medicine;meetings;Mentored Patient-Oriented Research Career Development Award;Mentorship;Mucous Membrane;multidimensional data;Mus;Mycoplasma hominis;novel strategies;Observational Study;Outcome;Patients;Phenotype;Physicians;Predisposition;Prevotella;primary outcome;Public Health;recruit;reproductive;Reproductive Immunology;Research;Risk;Role;Sampling;Scientist;skill acquisition;skills;Stains;Submucosa;Swab;symptom treatment;T-Cell Activation;T-Lymphocyte;Testing;Tissues;Training;Training Programs;Translational Research;translational study;Universities;Vagina;vaginal microbiome;vaginal microbiota;Visit;Washington;Woman;Women's study;Work

PROJECT_TITLE: The impact of vaginal microbiota on cervical dendritic cells: an observational study of women from sub-Saharan Africa at high risk for HIV acquisition.

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Pediatric

ORG_CITY: Columbus

ORG_DEPT: MISCELLANEOUS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Fostering children’s social and behavioral skills in the early childhood years has the potential to create long- term benefits for individuals and society at large. Understanding how early educational settings help to promote them is still unclear. This study will use three large, national datasets to examine how preschool and kindergarten environments, and the alignment across them, shape young children’s social and behavioral development.

PI_NAMEs: ANSARI, ARYA ;PURTELL, KELLY M (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Address;Behavior;Behavioral;career;Child;Child Development;Data;Data Set;Development;early childhood;early experience;Early Intervention;Education;educational atmosphere;Ensure;Environment;experience;foster child;Foundations;Future;Health;improved;Individual;insight;Institution;Investigation;Investments;Justice;kindergarten;Knowledge;Learning;Lobe;longitudinal dataset;Modeling;multiple data sources;Nature;Nursery Schools;Outcome;Pattern;Personal Satisfaction;Preschool Child;programs;Public Health;Reproducibility;Research;Schools;Shapes;skills;social;social skills;Societies;Subgroup;success;United States;Work

PROJECT_TITLE: Children's Early Educational Experiences and their Social and Behavioral Development

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Clinical Research;Genetics;Kidney Disease;Machine Learning and Artificial Intelligence;Organ Transplantation;Prevention;Regenerative Medicine;Transplantation

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Despite the improved short-term outcomes in kidney transplantation (KT), comparable progress in long-term allograft survival has not been achieved with chronic allograft dysfunction (CAD) accounting for most cases of graft loss. Results from our proposed studies will provide a unique understanding of the early molecular triggers that determine graft outcomes and ultimately lead to CAD. Novel prognostic biomarkers will enable the early identification of patients at higher risk for progression to CAD, such that their use in patient monitoring as well as the development of new therapeutic modalities targeting our identified molecular triggers have the potential to avoid irreversible graft injury and improve long-term outcomes in KT recipients.

PI_NAMEs: ARCHER, KELLIE J.;MAS, VALERIA RAQUEL (contact)

PROGRAM_OFFICER_NAME: ROBIEN, MARK ANDREW

PROJECT_TERMS: Accounting;Acute;Allografting;Atrophic;Automobile Driving;Biological Markers;Biological Process;biomarker identification;Biopsy;CD28 gene;Cells;Characteristics;Chronic;Clinical;cohort;Complex;CXCR4 gene;Data;deep neural network;Development;Early identification;Event;Fibrosis;Functional disorder;Gene Expression Profile;Genes;genetic signature;Goals;graft dysfunction;graft function;Graft Survival;high risk;Histologic;Immune;immune activation;Immunologics;Impairment;improved;Inflammatory Response;Injury;injury burden;Injury to Kidney;Innate Immune Response;interstitial;Kidney;kidney allograft;Kidney Transplantation;Knowledge;Machine Learning;Mediating;Metadata;Modality;Modification;Molecular;Molecular Profiling;Nature;novel;novel therapeutics;Organ;Organ Donor;organ injury;Outcome;outcome prediction;Patient Monitoring;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;post-transplant;preimplantation;prevent;Prognostic Marker;progression risk;prospective;Protocols documentation;RANTES;repaired;Reporting;Research Design;response;Risk;risk prediction;Sampling;stressor;Testing;Time;transcriptome;transcriptome sequencing;transcriptomics;Transplant Recipients;Transplantation;Tubular formation;Untranslated RNA;Variant;wound

PROJECT_TITLE: Pretransplant comprehensive scores to predict long term graft outcomes

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative  Clostridium perfringens enterotoxin (CPE) is responsible for the symptoms of several very important intestinal diseases, including the 2nd most common bacterial foodborne illness in the USA. This proposal will address four major gaps in understanding CPE-action and CPE-mediated diseases, namely: i) whether pore formation is required for CPE intestinal activity, ii) the importance and mechanism of indirect effects, like bystander cell killing, on CPE-induced intestinal damage, iii) the mechanistic basis for CPE binding, oligomerization and pore formation and iv) the effects of intestinal lumen contents on CPE processing and C. perfringens sporulation, which is essential for CPE production. This proposal will address these knowledge deficits by using a combination of in vitro, ex vivo and in vivo studies, with the eventual goal of elucidating processes that could be inhibited by therapeutics.

PI_NAMEs: MC CLANE, BRUCE A (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: absorption;Address;Adjuvant;Animal Model;antibiotic-associated diarrhea;Apoptosis;bacteria classification;bile salts;Binding;Biological Models;Black Box;C-terminal;Caco-2 Cells;Calcium;Calpain;cancer cell;cancer therapy;Cell Death Induction;cell killing;Cell membrane;Cells;Cessation of life;Chloroquine;chymotrypsin;Clinical;Clostridium perfringens;Clostridium perfringens enterotoxin;Colon;Complex;Constipation;cytokine;Cytolysis;cytotoxicity;Diagnostic;Disease;Drug Delivery Systems;Enteritis;Enterotoxemia;enterotoxin receptor;Enterotoxins;Environment;Event;extracellular;Extracellular Domain;Fecal Impaction;Food Poisoning;foodborne illness;Gastrointestinal Diseases;Gastrointestinal tract structure;Goals;Human;human pathogen;Image;improved;In Vitro;in vivo;Infection;Ingestion;Intestinal Absorption;Intestinal Content;Intestinal Diseases;intestinal villi;Intestines;Knowledge;Lipid Bilayers;Liquid substance;Liver;Mediating;Molecular;Mothers;mucosal vaccination;Mus;Organ;overexpression;Pathology;Peptide Hydrolases;Permeability;Persons;Plasma Cells;Process;Production;Proline;Quinacrine;receptor;receptor binding;Regulation;Reproduction spores;Serine Protease;Small Intestines;Specificity;Structure;Study models;Surface;Symptoms;System;Testing;Therapeutic;Tight Junctions;Toxin;translational applications;Trypsin;Variant;Villus

PROJECT_TITLE: Mechanism of action of C. perfringens enterotoxin

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Asthma;Chronic Obstructive Pulmonary Disease;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: NARRATIVE This grant application will support Dr. Woodruff to mentor physician-scientist mentees in Patient Oriented Research that focuses on understanding disease mechanisms and classifying patients based on the biology underlying their asthma and COPD. In addition, Dr. Woodruff will pursue another research direction through the study of racial disparities in lung disease. Using the time and support provided by this award, he will continue to direct a “Pulmonary Precision Medicine Core Laboratory” at UCSF which will provide space and resources and a common area for seminars and formal teaching in methods related to Patient Oriented Research.

PI_NAMEs: WOODRUFF, PRESCOTT G (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: African American population;Airway Disease;airway epithelium;Applications Grants;Area;Asthma;Award;Biology;career;Cementation;Characteristics;Chronic Obstructive Pulmonary Disease;Cilia;Classification;Clinical;clinical care;Clinical Research;cohort;Consensus;Data;design;Development;Disease;Disparity;Drug Metabolic Detoxication;Educational Curriculum;Educational process of instructing;endoplasmic reticulum stress;Ensure;Equation;experience;Faculty;Fortune;Funding;Genomics;Goals;Grant;Health;health disparity;Human;human old age (65+);Incubated;Individual;Inflammation;innovation;Institutional Review Boards;interest;Interferons;Laboratories;laboratory experience;Longitudinal cohort;Lung;Lung Diseases;Maintenance;Measures;Medicine;member;Mentors;Methods;Modernization;Molecular;multidisciplinary;National Heart, Lung, and Blood Institute;novel;Obstructive Lung Diseases;Pathologic;Pathway interactions;patient oriented;patient oriented research;Patients;Physicians;precision medicine;Predictive Value;preservation;programs;Publishing;pulmonary function;Pulmonary function tests;Race;racial disparity;Research;Research Methodology;resilience;Resources;Respiratory Disease;Risk;Role;Sampling;Scientist;Series;Severities;Severity of illness;skills;Smoker;Smoking;Societies;Structure;success;Symptoms;Systematic Bias;targeted treatment;Testing;Time;time use;Tissue Banks;tool;Training;Translational Research;translational research program;United States National Institutes of Health;Work

PROJECT_TITLE: Mentoring Research in Precision Medicine for Lung Disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Human Genome;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE Our previous work suggests that there is a pathway downstream of NUMB that confers “gonadal” competence on cells that have entered the gonad from the coelomic epithelium. Many lines of evidence point to the hypothesis that bHLH proteins are this missing link and are opposed by SOX factors in the male pathway. We will test this hypothesis and also discover how these transcription factors mediate chromatin conformational changes that alter accessibility of genes associated with the male or female pathways.

PI_NAMEs: CAPEL, BLANCHE  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: ATAC-seq;Berlin;BHLH Protein;Binding;Binding Sites;Biological Process;Cell Differentiation process;Cell Lineage;Cells;ChIP-seq;Chromatin;Chromatin Loop;Code;Collaborations;Competence;Complex;Data Set;Development;Dimerization;DNA Methylation;Embryo;Enhancers;Epigenetic Process;Epithelium;Family;Feedback;Female;FOXL2 gene;Genes;Genetic Transcription;Gonadal structure;granulosa cell;Helix-Turn-Helix Motifs;Hi-C;histone modification;Histones;inhibitor;Licensing;Link;male;Mammals;Maps;Mediating;methylome;Modeling;Modification;Molecular Conformation;mutant;Mutant Strains Mice;notch protein;Notch Signaling Pathway;Nucleosomes;Numbness;Ovary;Pathway interactions;Polycomb;Positioning Attribute;progenitor;promoter;Proteins;Quantitative Reverse Transcriptase PCR;Repression;sertoli cell;sex determination;Somatic Cell;stem;Structure;Supporting Cell;System;TCF7L2 gene;Testing;Testis;three-dimensional modeling;Time;transcription factor;transcriptome;Work

PROJECT_TITLE: Opposing Pathways in Mammalian Sex Determination

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Nutrition;Sleep Research

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Olfactory function is important for many aspects of human health and is influenced by numerous factors including physiological states. This project is designed to test the role of neurons found in the hypothalamus that respond to food deprivation and sleep states on olfactory function. The ultimate goal of this proposal is to determine the contribution of melanin-concentrating hormone to detection and discrimination of odors in the environment.

PI_NAMEs: ALVINA, KARINA  (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Ablation;Acute;Address;Affect;Animals;Anterior;Area;Axon;Behavior;behavior test;Behavioral;behavioral outcome;behavioral response;Biochemical;Biological Assay;Brain;Brain region;Cells;cellular targeting;Central Nervous System;Chemicals;Cilia;ciliopathy;circadian;design;Detection;Eating;Environment;Excision;experimental study;feeding;Feeding behaviors;Food;Food deprivation (experimental);food restriction;Functional disorder;Future;Gene Expression;Genes;Genetic;genetic manipulation;glutamatergic signaling;Goals;Grant;habituation;Health;hormonal signals;Human;Hunger;Hypothalamic structure;Image;Immediate-Early Genes;insight;Interneurons;Lateral;Maps;MCHR1 gene;Mediating;melanin-concentrating hormone;melanin-concentrating hormone receptor;mitral cell;Modeling;Molecular;Monitor;mouse model;Mus;mutant;Mutant Strains Mice;Nasal cavity;Neurons;Neuropeptides;Neurophysiology - biologic function;neuroregulation;Obesity;odor discrimination;Odors;olfactory bulb;Olfactory Epithelium;olfactory nuclei;Olfactory Pathways;olfactory sensory neurons;Olfactory tubercle;open field behavior;Organelles;Organism;Pathway interactions;Patients;Peptides;pharmacologic;Phenotype;Physiological;piriform cortex;Play;Population;Process;Quality of life;receptor;Regulation;REM Sleep;Research;response;Role;Satiation;Sensory;sensory mechanism;sensory system;Signal Pathway;Signal Transduction;Site;Sleep;Sleep Deprivation;sleep pattern;Smell Perception;Techniques;Testing;transmission process;Viral;Volatilization;Wakefulness;Western Blotting;Whole Body Plethysmography

PROJECT_TITLE: Centrifugal regulation of olfactory function by melanin-concentrating hormone

STUDY_SECTION: CSS

STUDY_SECTION_NAME: Chemosensory Systems Study Section[CSS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Stimulant Use and Misuse;Substance Misuse

PHR: Drugs of abuse alter gene expression and epigenetic modifications in brain reward circuits, but it is not clear what molecular mechanisms regulate this process or how drug experience can result in long-lasting epigenetic changes. This proposal will examine the role of Gadd45b, a gene linked to experience-dependent DNA methylation changes, in regulation of the molecular and genetic mechanisms that contribute to cellular and behavioral responses to cocaine. This research will contribute fundamental knowledge to our understanding of how brain circuits drive motivated behaviors in the context of substance abuse disorders, and has the potential to identify novel cellular targets for addiction therapeutics.

PI_NAMEs: DAY, JEREMY J (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Adaptive Behaviors;addiction;Adult;Affect;Behavior;Behavioral;Behavioral Assay;behavioral plasticity;behavioral response;Binding;Biological Assay;bisulfite sequencing;Brain;Brain region;Cell Nucleus;Cells;cellular pathology;cellular targeting;Central Nervous System;ChIP-seq;Clustered Regularly Interspaced Short Palindromic Repeats;Cocaine;cocaine receptor;cocaine reward;Corpus striatum structure;crosslinking and immunoprecipitation sequencing;Data;demethylation;Disease;DNA;DNA Damage;DNA Methylation;DNA methylation profiling;Dopamine;Dopamine Receptor;drug action;drug maintenance;drug of abuse;Economics;Epigenetic Process;epigenome;experience;experimental study;Family member;Future;GADD45B;Gene Expression;Genes;Genetic;Genetic Transcription;genome-wide;Growth;Immunoprecipitation;In Vitro;in vivo;Individual;knock-down;Knowledge;learned behavior;Learning;Link;long term memory;Mediating;Memory;Messenger RNA;Modification;Molecular;motivated behavior;neuroadaptation;neurogenesis;Neurons;neuropsychiatric disorder;neurotransmission;novel;Nucleus Accumbens;overdose death;overexpression;Pharmaceutical Preparations;Play;Population;Process;programs;Property;Protein Family;Proteins;psychostimulant;Public Health;Publishing;Regulation;Regulatory Pathway;Reporter;Reporting;Research;response;Rewards;Ribosomes;RNA;RNA Binding;Role;Signal Transduction;single nucleus RNA-sequencing;social;Stimulant;stimulant abuse;Structure;Substance abuse problem;Sucrose;Synapses;synaptic function;Synaptic plasticity;Testing;Therapeutic;Time;tool;Transcript;Transcription Coactivator;transcriptomic profiling;United States;Variant;Work

PROJECT_TITLE: Role of Gadd45b in Cocaine-driven Epigenetic and Behavioral Dynamics

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Cardiovascular;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Rare Diseases;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Abdominal aortic aneurysm (AAA) is a life-threatening condition in adults, especially in male individuals, because estrogen and estrogen receptors have protective roles against AAA in females. A new mechanism was identified by which a factor, KLF14, inhibits inflammation and increases estrogen receptors in macrophages. The information generated from this study will promote the development of more effective drug therapies for the prevention of rupture or to promote reversion of AAA, which currently are not available.

PI_NAMEs: CHEN, YUQING EUGENE (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: abdominal aorta;Abdominal Aortic Aneurysm;Adult;Animal Model;Antiinflammatory Effect;Aortic Rupture;Biological Process;Cardiovascular Diseases;Cells;ChIP-seq;Cholesterol;Chronic;Chronic Disease;Clinical;Coupled;Data;Death Rate;Development;Dilatation - action;Disease;Dissection;effective therapy;Eligibility Determination;ESR1 gene;Estrogen Receptor 2;Estrogen Receptors;Estrogen Therapy;Estrogens;Female;Foundations;Functional dependence;gain of function;Gelatinase B;Genetic study;Genetic Transcription;GTP-Binding Proteins;Heart failure;Hormones;Human;Human Genetics;Hydroxycholesterols;Impairment;In Vitro;Incidence;Individual;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Knockout Mice;Life;lipid metabolism;loss of function;Macrophage;male;Matrix Metalloproteinases;Mediating;men;Metabolic Diseases;mouse model;Mus;Myelogenous;Myeloid Cells;new therapeutic target;Nuclear;Operative Surgical Procedures;Oral Administration;p65;Pathway interactions;Patients;pharmacologic;Pharmacotherapy;Phenotype;Physiological;Prevalence;Prevention therapy;protective effect;receptor;repaired;Reporting;Research;Risk Factors;Role;Rupture;sex;Sex Differences;sex disparity;side effect;Solid;Survival Rate;Testing;Therapeutic;Time;transcription factor;Transgenic Organisms;Woman;Women's prevalence

PROJECT_TITLE: KLF14 and Cardiovascular Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-D(02)M]


FUNDING_MECHANISM: OTHERS

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Sarah L. Krein, PhD, RN is an active and productive health services and nurse researcher. She uses her clinical knowledge and research expertise to conduct and collaborate on studies to improve healthcare safety, quality, and effectiveness as well as Veteran health outcomes. She also works with clinician and non-clinician scientists who are beginning their research careers, assisting them in learning new research skills and supporting them as they move on to leading their own research studies. The support provided by the VA senior research career scientist award will allow her to continue to use her research expertise and experience to continue conducting research that improves VA healthcare delivery and patient safety, educate new researchers, work with local, national and international collaborators and contribute to activities that support the VA research, education and care delivery missions.

PI_NAMEs: KREIN, SARAH  (contact)

PROJECT_TERMS: Acute;Address;Antibiotics;Area;Award;Behavior;Benzodiazepines;Books;care delivery;Care given by nurses;care outcomes;career;Caring;catheter associated UTI;Catheters;Chronic;chronic pain;chronic pain management;Clinical;clinical care;clinical practice;Collaborations;Communication;Communities;community living;Complex;complex chronic conditions;design;disease transmission;Doctor of Philosophy;Education;Effectiveness;Ensure;Epidemiology;European Union;Evaluation;experience;Funding;Generations;Grant;Health;health care delivery;health care settings;health economics;Health Services;Health Services Research;Healthcare;Healthcare Systems;Heart Arrest;Hospitals;implementation research;improved;Infection prevention;infection rate;innovation;Interdisciplinary Study;interest;Internal Medicine;International;Investigation;Japanese;Journals;Knowledge;Learning;Long-Term Care;Medical center;Medical Research;Medicine;Mentors;Methodology;Methods;Michigan;Mission;multidisciplinary;New England;Nosocomial Infections;novel strategies;Nurses;Nursing Homes;Operative Surgical Procedures;Outcome;Outcomes and Health Services Research;Patient Care;patient safety;Patient-Focused Outcomes;Patients;Performance;Peripheral;personal protective equipment;prevent;Prevention;prevention practice;Prevention program;Principal Investigator;Productivity;programs;Proton Pump Inhibitors;provider communication;Publications;Publishing;Qualitative Methods;Quality of Care;Research;Research Design;Research Methodology;Research Personnel;research study;Research Technics;Research Training;Resuscitation;Risk;Risk Reduction;Safety;safety practice;Saints;Science;Scientist;Services;skills;Source;Technology;Text;Time;Training;Universities;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Research Career Scientist Award

STUDY_SECTION_NAME: HSR-7 Capacity Building[HSR7]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Machine Learning and Artificial Intelligence;Physical Activity;Physical Rehabilitation;Precision Medicine;Prevention;Rehabilitation

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The defining morbidity of heart failure is exercise intolerance, and while exercise training is known to benefit these patients, the molecular transducers of exercise’s benefit to patients are unknown. This study will investigate the proteomic profiles of exercise training in heart failure patients and compare them to proteomic profiles in healthy adults. The results will not only identify biological pathways for further investigation as potential drug targets for symptom reduction, but also provide a proteomic framework for exercise training response in heart failure.

PI_NAMEs: KATZ, DANIEL HUNTER (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Address;Adipose tissue;Adult;adverse outcome;Angiopoietin-2;Area;Attention;biobank;Bioinformatics;Biological;Biological Process;Biology;Biopsy;Blood Vessels;Cardiac;Cardiac rehabilitation;Cardiomyopathies;Cardiopulmonary;cardiovascular health;Cardiovascular system;career development;Classification;Clinical;Clinical Trials;cohort;Collaborations;Data;Development;Development Plans;Disease;Drug Targeting;EFRAC;Endoglin;Enrollment;Exercise;exercise intolerance;Exercise Physiology;exercise prescription;Exercise Test;exercise training;experience;Extracellular Matrix;Extracellular Matrix Proteins;Future;Genetic;Genetic Medicine;Genetic Techniques;genetic variant;Heart failure;Human;Immersion;improved;instrument;interest;Intervention;Investigation;Life;Link;link protein;Machine Learning;machine learning algorithm;Measures;Mediating;Mediator;Mendelian randomization;Mentors;Methods;MME gene;Molecular;Molecular Profiling;Morbidity - disease rate;multiple omics;Muscle;Myocardial dysfunction;Nature;novel;Outcome;Participant;Pathway interactions;Patients;Performance;Peripheral;Pharmacotherapy;Physical activity;Physiological;Plasma;Play;Population;population based;Population Study;precision medicine;prevent;Protein Tyrosine Kinase;Proteins;proteomic signature;Proteomics;Protocols documentation;Publications;Quality of life;Randomized;reduce symptoms;Rehabilitation therapy;Research;response;Sampling;Shortness of Breath;Standardization;Stimulus;Subgroup;symptomatic improvement;Symptoms;targeted treatment;Techniques;Testing;therapeutic target;Tissue Sample;Tissues;Training;trait;Transducers;Treatment Failure;Vascular Endothelium;Work;working group

PROJECT_TITLE: Identifying Proteomic Markers of Exercise Training in Heart Failure

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: BLACKSBURG

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Long non-coding RNAs (lncRNAs) have been poorly characterized due to their low abundance. In this project, we will develop a low-input microfluidic technology to profile genome-wide lncRNA-chromatin binding using scarce tissue samples.

PI_NAMEs: LU, CHANG  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Anti-sense DNA;Binding;Binding Sites;Biological Assay;Biological Process;Biology;Brain;Cell Line;Cell Nucleus;cell type;Cells;Chromatin;chromatin isolation by RNA purification sequencing;Clinical;Code;Complex;crosslink;Cues;Development;Disease;DNA;epigenomics;Future;Gene Expression;Genome;genome-wide;genome-wide analysis;Genomic DNA;high throughput technology;individual patient;Length;Location;Lung;magnetic beads;MALAT1 gene;Manuals;Maps;Methods;Microfluidic Microchips;microfluidic technology;Microfluidics;Molecular;Morphologic artifacts;Mus;Oligonucleotide Probes;operation;overexpression;parallel processing;Patients;Play;precision medicine;Process;Proteins;Protocols documentation;Regulation;Reproducibility;RNA Binding;RNA purification;Role;Sampling;scaffold;Signal Transduction;Stimulus;System;Technology;Technology Assessment;Testing;Tissue Sample;Tissues;tool;tumor;Untranslated RNA;Work

PROJECT_TITLE: A low-input microfluidic ChIRP-seq technology for studying endogenous lncRNA binding

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Precision Medicine;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE  The proposed K01 project will use multimodal magnetic resonance imaging and machine learning techniques to elucidate the structural and functional brain mechanisms underlying treatment failure in young adults receiving treatment with injectable extended-release naltrexone (XR-NTX) for opioid use disorder. This project will unveil the neural mechanisms underlying individual variability in XR-NTX treatment response in a population of high importance to the efforts to curb the opioid crisis. It will facilitate Dr. Zhenhao Shi's transition to an independent computational addiction neuroscientist and help inform future research of, and intervention strategies for, opioid addiction.

PI_NAMEs: SHI, ZHENHAO  (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: Abstinence;addiction;Adherence;Affect;Area;Behavior assessment;Behavioral;Behavioral Research;Brain;brain magnetic resonance imaging;Brain region;career;career development;Cause of Death;Characteristics;Clinic Visits;Clinical;Clinical assessments;clinical predictors;Clinical Research;Cognitive;cognitive neuroscience;Collaborations;Complement;craving;cue reactivity;Cues;Data;Data Analyses;Data Set;demographics;Dependence;design;Disease;Dropout;Effectiveness;Endocrine;experience;Failure;follow-up;Functional Magnetic Resonance Imaging;Goals;gray matter;Heterogeneity;high dimensionality;high risk;imaging modality;improved;indexing;Individual;Individual Differences;individual variation;Injectable;Injections;Intervention;Knowledge;Leadership;Link;Literature;Machine Learning;machine learning algorithm;machine learning method;machine learning model;Magnetic Resonance Imaging;Measures;Medial;medication-assisted treatment;Methodology;Methods;Modality;Modeling;multimodal learning;multimodality;Naltrexone;Nature;neural;neural model;Neurocognitive;neuroimaging;neuromechanism;Neuropsychology;Neurosciences Research;novel;Opiate Addiction;Opioid;Opioid agonist;Opioid Antagonist;opioid epidemic;opioid overdose;opioid use disorder;Outcome;Patient Schedules;Patient Self-Report;Patients;Pattern;Pharmaceutical Preparations;Physiological;Population;Prediction of Response to Therapy;predictive modeling;Predisposition;primary outcome;Process;Productivity;prospective;recruit;Relapse;relapse prediction;relapse prevention;Research;response;Rest;ROC Curve;Schedule;secondary outcome;Self-Examination;side effect;skills;Structure;Substance Use Disorder;success;Techniques;Toxicology;Training;Translational Research;Treatment Failure;Treatment outcome;treatment response;treatment risk;Urine;Ventral Striatum;Writing;young adult

PROJECT_TITLE: Multivariate Modeling of the Neural Mechanisms of Treatment Response in Opioid Addiction

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: DOVER

ORG_NAME: DELAWARE DIVISION OF PUBLIC HEALTH

ORG_STATE: DE

PHR: Component A, Delaware PRAMS (Pregnancy Risk Assessment Monitoring System) Project Project Narrative The overall purpose of PRAMS (Pregnancy Risk Assessment Monitoring System) is to reduce infant morbidity and mortality and to promote maternal health by influencing maternal and child health (MCH) programs, policies, and maternal behaviors during pregnancy and early infancy. The information obtained from PRAMS will lead to improvement in the health of mothers and infants in the state of Delaware. Implementing the state-wide PRAMS project will help in identifying risk factors specific to Delaware mothers and infants for intervention, modification of existing prevention and service programs based on study findings, and community awareness of risk factors for birth complications disseminated through research results.

PI_NAMEs: YOCHER, GEORGE  (contact)

PROJECT_TITLE: DP21-001 Delaware PRAMS (Pregnancy Risk Assessment Monitoring System) Project


ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA STATE DEPARTMENT OF HEALTH

ORG_STATE: OK

PHR: Oklahoma Pregnancy Risk Assessment Monitoring System (PRAMS)  Component A Core Surveillance Project Narrative The overall goal of PRAMS is to reduce maternal and infant morbidity and mortality. Data gathered by PRAMS are used to: 1) document trends in adverse birth outcomes and other reproductive health and MCH outcomes; 2) identify subpopulations at greatest risk for the adverse birth outcomes, and inform prevention strategies and program development; 3) inform the Title V needs assessment process to help states plan for and allocate MCH block grant funds and to provide background information for states that apply for other grant funds; 4) develop and evaluate programs and policies that support improvement of maternal and child health; 5) investigate merging issues in reproductive health; and 6) support health professionals to incorporate the latest research findings into their standards of practice. Relevance to Public Health Oklahoma PRAMS data contribute to maternal and child health planning and decision-making state-wide. The information derived from PRAMS furthers the core public health function of assessment for pregnancy-related health issues in Oklahoma. Oklahoma PRAMS data are routinely used in the assessment of maternal and infant health status, determining accessibility of preconception, pregnancy, and postpartum services, examining prevalence of emerging health issues, and in the identification of maternal and infant health hazards.

PI_NAMEs: KUNNEL, BINITHA  (contact)

PROJECT_TITLE: DP21-001 The Oklahoma Pregnancy Risk Assessment Monitoring System (PRAMS)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Olfactory loss is reported as an early symptom and predictor for COVID-19. The supporting sustentacular cells but not the olfactory sensory neurons in the olfactory epithelium are permissive for SARS-CoV-2 infection. The goal of this proposal is to better understand the innate responses in sustentacular cells upon SARS-CoV-2 infection and how these responses contribute to olfactory dysfunction.

PI_NAMEs: GONG, QIZHI  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: 2019-nCoV;ACE2;Acute;Animal Model;Anosmia;Apical;Applied Genetics;Axon;Biological Assay;Brain;Cell Culture System;Cell Culture Techniques;Cell Line;Cell Shape;cell type;Cells;chemokine;Chronic;Clinical;COVID-19;COVID-19 associated anosmia;cribriform plate;cytokine;Engineering;Environment;Exhibits;Fluorescence-Activated Cell Sorting;genetic manipulation;Glass;Goals;Human;Immune;Infection;Inflammation;Inflammatory Response;innate immune function;Innate Immune Response;insight;K-18 conjugate;Mediating;Microbe;Molecular;mouse model;Mouse Strains;Mus;Nervous System Disorder;neuroepithelium;Neurologic Symptoms;Neuronal Dysfunction;Neurons;Nose;novel;olfactory bulb;Olfactory dysfunction;Olfactory Epithelium;Olfactory Mucosa;olfactory receptor;olfactory sensory neurons;pathogenic virus;Pathogenicity;Pathway interactions;Patients;permissiveness;post SARS-CoV-2 infection;Process;receptor;Receptor Down-Regulation;receptor downregulation;receptor expression;Regulation;Reporter Genes;Reporting;Research;response;SARS-CoV-2 infection;SARS-CoV-2 positive;seal;Signal Transduction;single-cell RNA sequencing;sustentacular cell;Symptoms;Testing;Thick;Tissues;TLR4 gene;Transcript;transcription factor;Transgenic Organisms;Viral;Virus Diseases;Virus Replication

PROJECT_TITLE: Innate immune responses to SARS-CoV-2 infection in the olfactory epithelium

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ORG_CITY: TOPEKA

ORG_NAME: KANSAS STATE DEPT OF HLTH AND ENVIRONMNT

ORG_STATE: KS

PHR: Kansas PRAMS: Component A (Core Surveillance) Project Narrative Kansas Pregnancy Risk Assessment Monitoring System (PRAMS) is a population-based survey that collects information on Kansas mothers who have recently given birth to a live-born infant. The survey asks information about their experiences, behaviors, and attitudes before, during, and shortly after pregnancy. The PRAMS data are used to identify groups of women and infants in Kansas at high risk for health problems, to monitor changes in health status, and to measure progress towards goals in improving the health of mothers and infants.

PI_NAMEs: SMITH, CHRISTINA D (contact)

PROJECT_TITLE: DP21-001 Kansas PRAMS Project


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Services

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The proposed research investigates the effects of enrollment in private Medicare Advantage plans versus traditional Medicare on health care use, health care quality, and patient outcomes. The analysis will focus on recent policies in several large states mandating that retired state workers receive their health benefits through Medicare Advantage, which shifted public retirees between traditional Medicare and Medicare Advantage. Given growing enrollment in the Medicare Advantage program, the findings from this project will provide important evidence of the program’s effect on patient health.

PI_NAMEs: HUCKFELDT, PETER  (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: acute care;Admission activity;beneficiary;Budgets;care providers;Caring;Characteristics;Communities;Complex;Congresses;cost;Cost Sharing;Data;design;Drug Prescriptions;Drug usage;Emergency department visit;Enrollment;Fee-for-Service Plans;financial incentive;flexibility;Freedom;functional status;Geographic Locations;Grant;Health;Health Benefit;health care quality;Health Status;Healthcare;Hip Fractures;Home Care Services;Hospitalization;Hospitals;improved;Incentives;innovation;Institution;Insurance Carriers;Measures;Medicare;mortality;Myocardial Infarction;Natural experiment;Occupations;older adult;Outcome;Outpatients;patient subsets;Patient-Focused Outcomes;Patients;payment;Performance;Pilot Projects;Policies;Policy Maker;prior authorization;Privatization;programs;Provider;provider networks;Quality of Care;Research;residence;retiree;Service provision;Services;Severities;Signal Transduction;Stroke;Structure;Telemedicine;tool;United States Centers for Medicare and Medicaid Services;Variant;Visit;Work

PROJECT_TITLE: The Effects of Medicare Advantage on Healthcare Use and Patient Outcomes

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS STATE DEPT OF PUB HEALTH

PHR: Project Narrative The mission of the Massachusetts Department of Public Health (MDPH) is to prevent illness, injury, and premature death, to assure access to high quality public health and health care services, and to promote wellness and health equity for all people in the Commonwealth. MDPH aims to provide timely access to data to reduce disparities and improve outcomes, address the social determinants of health which contribute to health inequities, and eliminate institutional and structural racism.The Massachusetts Pregnancy Risk Assessment Monitoring System (PRAMS) provides data on maternal experiences and behaviors before, during and shortly after pregnancy that can be used to inform and improve maternal and child health programs and policies, furthering the mission of MDPH and promoting the health of Massachusetts families.

PI_NAMEs: STONE, SARAH LEDERBERG (contact)

PROJECT_TITLE: DP21-001 Component A [Core]: Massachusetts Pregnancy Risk Assessment Monitoring System (PRAMS)


ORG_CITY: MONTGOMERY

ORG_NAME: ALABAMA STATE DEPT OF PUBLIC HEALTH

ORG_STATE: AL

PHR: Project Narrative  The Alabama Pregnancy Risk Assessment Monitoring System (PRAMS) Project is a survey sent to women who have recently given birth. The survey covers various topics concerning their health behaviors and experiences before, during, and after the pregnancies. The PRAMS survey is a comprehensive tool that provides an accurate picture of the health of mothers and infants in Alabama. PRAMS data will be used to create informational materials (e.g., fact sheets, data brief, infographics) to educate the public and providers on health and safety topics, such as the importance of receiving dental care during pregnancy, safe sleep for infants, and nutrition during pregnancy. PRAMS data will be presented to highlight the importance on overall health care during pregnancy and barriers to care faced by pregnant women in Alabama. PRAMS data will be used by the state of Alabama to plan and review programs and policies aimed at reducing health problems among mothers and babies. The data will also be shared with other state and local agencies that have important contributions to make in planning maternal and infant health programs and to develop partnerships with those agencies.

PI_NAMEs: FEUSER, TIM  (contact)

PROJECT_TITLE: DP21-001 Alabama Pregnancy Risk Assessment Monitoring System (PRAMS)


ORG_CITY: BISMARCK

ORG_NAME: NORTH DAKOTA STATE DEPARTMENT OF HEALTH

ORG_STATE: ND

PHR: RESEARCH AND RELATED Other Project Information 8. Project Narrative The North Dakota Department of Health (NDDoH) is applying to implement the Component A: Core Surveillance Pregnancy Risk Assessment Monitoring System (PRAMS). The purpose of PRAMS in the state will be to initiate and enhance surveillance on maternal and early infancy risk factors in order to translate data into relevant public health interventions that will improve the health of mothers and infants in North Dakota.

PI_NAMEs: NJAU, GRACE  (contact)

PROJECT_TITLE: DP21-001 North Dakota Pregnancy Risk Assessment Monitoring System (ND PRAMS)


ORG_CITY: WASHINGTON

ORG_NAME: DC DEPARTMENT OF HEALTH

ORG_STATE: DC

PHR: PRAMS is a population-based surveillance project of the CDC and state health departments. PRAMS collects state-specific data for the District of Columbia on maternal attitudes and experiences before, during and shortly after pregnancy.

PI_NAMEs: OANDASAN, PAMELA  (contact)

PROJECT_TITLE: DP21-001 PRAMS DISTRICT OF COLUMBIA


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Our aged TB chemotherapeutic regimen is insufficient to treat drug resistant tuberculosis (DR-TB) patients. Accumulating evidence has shown that DR-TB develops through cyclic formation of persisters, a phenotypic variant that is tolerant to all TB antibiotics. In this proposal, we will show that persister metabolic remodeling plays an important role in the development of DR-TB, thereby serving as a potential source of adjunctive drug targets to synergize antibiotic effects with the conventional TB treatment regimen.

PI_NAMEs: EOH, HYUNGJIN  (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Aftercare;aged;Anabolism;antibiotic tolerance;Antibiotics;Antitubercular Antibiotics;Bacillus;Bacterial Infections;bactericide;base;C3HeB/FeJ Mouse;Carbon;Cell Wall;Clinical;Cord Factors;cost;CRISPR interference;Cross-Sectional Studies;Development;Disaccharides;Disease;drug development;Drug resistance;drug resistance development;Drug resistance in tuberculosis;Drug Targeting;Drug Tolerance;drug-sensitive;Dyes;epidemiology study;Exhibits;Flow Cytometry;Genomics;Glycolipids;Goals;Health;Heterogeneity;high risk;Human;Immune system;In Vitro;in vivo;Infection;inhibitor;insight;Intrinsic factor;Label;Link;Mediating;Messenger RNA;Metabolic;Metabolism;metabolomics;Microbial Biofilms;mortality;mouse model;Multidrug-Resistant Tuberculosis;mutant;Mutation;Mycobacterium tuberculosis;novel therapeutic intervention;novel therapeutics;Outcome;overexpression;pathogen;Pathogenesis;Patients;Pattern;Periodicity;Persons;Phenotype;Play;Population;Process;Public Health;Quantitative Reverse Transcriptase PCR;Regimen;Reporting;Research;resistance mutation;Role;Source;synergism;Testing;Therapeutic;Therapeutic Intervention;Treatment Protocols;Trehalose;Tuberculosis;tuberculosis drugs;tuberculosis treatment;validamycins;Variant;Virulence;Virulence Factors;Work

PROJECT_TITLE: Interplay of M. tuberculosis trehalose metabolism and its pathogenesis and drug resistance