ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Emergency medical services (EMS) serve as an important entry point in the United States’(U.S.) healthcare system, especially for Hispanic older adults who have challenges accessing preventive and diagnostic care, and who rely on emergency services to meet their healthcare needs. The goal of this dissertation is to advance our understanding of the individual, neighborhood, and structural-level factors that impact the provision of EMS to Hispanic older adults in the prehospital setting. The study findings can inform efforts to make EMS more accessible, age-friendly, and equitable.

PI_NAMEs: MELGOZA, ESMERALDA  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Accident and Emergency department;Address;Adopted;Adoption;Adult;Age;age group;aged;Ageism;Aging;Ambulances;American;Behavioral;Biological;California;Cardiac;care systems;Caring;Censuses;Characteristics;Clinical;Communities;Community Surveys;Computer software;coronavirus pandemic;County;COVID-19 impact;COVID-19 pandemic;Crime;Crowding;Data;Diagnostic;Eligibility Determination;Emergency Care;Emergency medical service;Emergency Medical Technicians;Emergency Medicine;emergency service responder;Emergency Situation;Equity;ethnic diversity;Ethnic Origin;Event;experience;Factor Analysis;Female;Foundations;Friends;Fright;Gender;Genetic;Goals;Guidelines;Health;health disparity;Health Personnel;Health Professional;Health Services;Healthcare;Healthcare Systems;Hispanic;Hispanic Populations;Hospitalization;human old age (65+);Human Resources;Individual;insight;Language;Literature;Logistic Regressions;Medical;Medicare;Mission;multilevel analysis;National Institute on Aging;Neighborhoods;older adult;Older Population;Oncology;pandemic disease;Paramedical Personnel;Patients;Policies;Population;Pre-hospital setting;Pre-hospitalization care;pre-pandemic;prevent;Preventive;Provider;psychiatric emergency;Psychiatric Emergency Services;Psychiatry;Public Health;racial diversity;racism;recruit;Research;Review Literature;Running;San Francisco;SARS-CoV-2 infection;Series;Service provision;Services;social;sociodemographics;Source;Statistical Data Interpretation;System;systematic review;telehealth;Time;Transportation;Triage;United States;Virus

PROJECT_TITLE: An Analysis Of The Multi-Level Factors That Impact Provision Of Emergency Medical Services To Hispanic Older Adults

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: AA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Excessive drinking is a significant public health problem that is intricately linked to stress. Although the stress response is a dynamic and widespread brain process, whether these unfolding changes help identify risky drinkers and explain changes in drinking-related cognition remains unclear. The proposed research integrates concurrent functional neuroimaging, neuroendocrine assays, cognitive tasks, and real-world monitoring together with the development of validated stress-predictive brain networks and novel dynamic algorithms to elucidate where, when, and how brain stress trajectories can be used to predict drinking.

PI_NAMEs: GOLDFARB, ELIZABETH  (contact);SCHEINOST, DUSTIN

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: acute stress;Adult;Alcohol consumption;alcohol use disorder;Alcohols;algorithm development;Algorithms;Architecture;Attention;Automobile Driving;Behavior;Behavior monitoring;behavior prediction;biological adaptation to stress;Biological Assay;Biological Markers;Brain;Brain region;candidate marker;Characteristics;Chronic;chronic alcohol ingestion;Clinical;clinically actionable;Cognition;Cognitive;cognitive neuroscience;cognitive process;cognitive task;Collection;Computational algorithm;Computer Models;connectome;connectome based predictive modeling;Data;Data Analyses;Data Collection;design;Development;diagnostic criteria;drinking;drinking behavior;early drinking;Endocrine;Functional Magnetic Resonance Imaging;Future;Goals;Grant;Heavy Drinking;high risk drinking;Individual;Individual Differences;insight;interdisciplinary approach;Intervention;Learning;Link;Machine Learning;machine learning method;Measures;meetings;Memory;Mental disorders;Modality;Monitor;neural;neural network;Neurocognitive;neuroimaging;Neurosecretory Systems;novel;Outcome;Pattern;Periodicity;Persons;Phenotype;predicting response;Prediction of Response to Therapy;Process;Public Health;Recovery;Relapse;Research;Research Personnel;response;risky driving;Sampling;secondary analysis;Stress;Stressful Event;success;Techniques;Testing;Time;Validation;Work

PROJECT_TITLE: Tracking brain dynamics of the acute stress response and neurocognitive mechanisms of chronic alcohol consumption

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Genetic Testing;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Brain malformations are a diverse group of disorders that can cause epilepsy, intellectual disability, and other neurodevelopmental impacts, with substantial impact on patients, families, and the health care system. To date, variants in hundreds of different genes have been reported to cause brain malformations, sometimes present in all cells of the brain and sometimes only in a subset (somatic mosaicism). This project brings together a multidisciplinary team of experts to curate the growing body of genetic data (genes and specific variants) related to brain malformations, to help clinicians select appropriate genes for testing and interpret results, in route to establishing a diagnosis and informing care.

PI_NAMEs: OLSON, HEATHER ELISA (contact);YANG, EDWARD

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acceleration;Adopted;AKT3 gene;Alleles;Area;Bioinformatics;Brain;brain cell;Brain Diseases;brain malformation;Caring;Categories;Child;Childhood;Classification;Clinical;clinical application;Clinical Management;clinical phenotype;clinically actionable;ClinVar;Cortical Dysplasia;Counseling;Data;design;Development;Developmental Brain Malformation;Developmental Disabilities;developmental genetics;Diagnosis;Diagnostic;Diagnostic tests;Disease;Epilepsy;Evaluation;Event;Family;fascinate;Focus Groups;Fostering;Foundations;FRAP1 gene;gene discovery;Genes;Genetic;genetic disorder diagnosis;Genetic Research;genetic testing;genetic variant;Genomics;Germ Cells;Germ Lines;Germ-Line Mutation;Goals;Grant;Health Care Costs;Healthcare Systems;hemimegalencephaly;Heritability;Heterozygote;Human Genetics;Infrastructure;Intellectual functioning disability;interest;KRAS2 gene;Laboratories;Laboratory Research;Lesion;Link;Literature;literature survey;Magnetic Resonance Imaging;malformation;Medicine;Megalencephaly;Microgyria;migration;Molecular;Morbidity - disease rate;mortality;mosaic;mosaic variant;Mosaicism;motor disorder;mTOR Inhibitor;multidisciplinary;Mutation;Natural History;Nervous System Disorder;Neurobiology;Neurologic;neuropathology;next generation sequencing;Pathway interactions;Patient Care;Patients;Pediatric Neurology;Phenotype;PIK3CA gene;PIK3CG gene;Precision therapeutics;Prognosis;Proliferating;Proto-Oncogene Proteins c-akt;Publishing;radiological imaging;Recurrence;Reporting;Reproducibility;Research;research clinical testing;Research Personnel;Resources;Risk;Route;Somatic Mutation;Structure;Subgroup;Temporal Lobe;Test Result;Testing;tumor;Variant;Work;working group;zygote

PROJECT_TITLE: Brain Malformation Expert Panels for Gene and Variant Curation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-V (50)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: HERSHEY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: The heart pumps blood into the systemic system by contracting cardiac muscle during systole, which is initiated by a rise in intracellular calcium concentration that triggers sliding of the thick and thin filaments in the muscle sarcomere. Myosin is the molecular motor that uses the energy from ATP hydrolysis to drive filament sliding and mutations in myosin can lead to dilated cardiomyopathy, a common form of heart failure that disrupts systolic contraction. This proposal will investigate the impact of dilated cardiomyopathy mutations on several aspects of human beta-cardiac myosin structure and function, including the regulatory mechanism, structural mechanism of force generation, and ability to drive filament sliding in a calcium dependent manner.

PI_NAMEs: WARSHAW, DAVID M;YENGO, CHRISTOPHER M (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Actins;Adopted;Area;arm;ATP Hydrolysis;ATP phosphohydrolase;beta-Myosin;Binding;Biological Sciences;Biomedical Engineering;Biophysics;Biosensor;blood pump;Calcium;Cardiac;Cardiac Myosins;Communication;Computer Models;Contracts;Data;Data Analyses;design;Dilated Cardiomyopathy;Disease;DNA;Electron Microscopy;Enzymatic Biochemistry;Equilibrium;experience;Experimental Designs;falls;Filament;Fluorescence Resonance Energy Transfer;Foundations;Generations;Genetic;Goals;Health;Heart;Heart failure;Human;human disease;Impairment;in silico;Individual;inherited cardiomyopathy;Kinetics;Lasers;Left;Link;Measures;Mechanics;medical schools;Mentors;Mentorship;Modeling;Molecular;Molecular Conformation;molecular mechanics;Molecular Motors;Molecular Structure;Motor;motor impairment;Muscle;Muscle Cells;Muscle Fibers;muscle physiology;mutant;Mutate;Mutation;Myocardium;Myopathy;Myosin ATPase;Nanotubes;Nonmuscle Myosin Type IIA;novel;Parents;Pathogenicity;Phase;Point Mutation;Postbaccalaureate;Power stroke;Production;Property;Reagent;recruit;Regulation;Relaxation;Reporting;Research;Research Project Grants;Resources;Sarcomeres;single molecule;skills;Slide;Striated Muscles;structural biology;Structure;System;Systole;Systolic Pressure;Therapeutic;Thick Filament;Thin Filament;Universities;Ventricular;Vermont

PROJECT_TITLE: Impact of dilated cardio myopathy mutations on cardiac myosin structure and function

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Alzheimer’s disease (AD) is a devastating neurodegenerative disorder affecting millions of elderly Americans but without a curative therapy, necessitating early detection for timely treatment before frank neurodegeneration occurs. The current proposal aims to examine subtle changes in language production in the earliest stages of AD progression by investigating the cognitive mechanisms underlying autocorrection, a type of speech error that is sensitive to AD biomarkers. The proposed studies will provide valuable insights into language impairments in cognitively healthy individuals at risk for AD, and will facilitate the development of simple, noninvasive, and low-cost diagnostic tools for preclinical AD.

PI_NAMEs: LI, CHUCHU  (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Address;Affect;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Attention;behavior test;Behavioral;Biological Markers;Categories;Clinical;Cognitive;Color;Complex;Computer Models;computerized tools;cost;curative treatments;Data;Development;Diagnosis;diagnostic tool;diaries;Disease Progression;Early Diagnosis;Elderly;Eye;Eye Movements;Foundations;Frequencies;Goals;Impairment;Individual;Ink;insight;Language;language impairment;Light;Linguistics;Measures;Methods;Monitor;Names;Nerve Degeneration;Neurodegenerative Disorders;Participant;pre-clinical;Probability;Production;Property;Reader;Reading;Retrieval;Role;Speech;symposium;syntax;Testing;Time;tool;Training;Visual;visual tracking;Voice;Writing

PROJECT_TITLE: Tracking Autocorrection to Explain its Sensitivity to AD

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: TUCSON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Coronary artery disease, which can ultimately cause ischemia and myocardial infarction, accounts for 1 in 6 deaths in the U.S., or nearly 400,000 deaths per year, and is the leading cause of heart failure, for which there is no cure. Clinically, the current optimal therapy is reperfusion to restore blood flow to the heart, but reperfusion itself contributes to the irreversible loss of functional myocardium. Our proposed studies address a new molecular mechanism that could decrease this damage, and has not been targeted by any therapeutics to date, supporting the significance of investigating it with the ultimate objective of developing novel treatments for decreasing heart damage and preventing heart failure.

PI_NAMEs: DOROUDGAR, SHIRIN  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Address;Affect;Age;Binding Proteins;Blood flow;Cardiac;Cardiac Myocytes;cardioprotection;Cell Communication;Cell Death;Cell Survival;Cells;Cessation of life;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coronary Arteriosclerosis;Coupled;Coupling;CRISPR-mediated transcriptional activation;Data;Elements;Endoplasmic Reticulum;Epitopes;Evaluation;Face;Fibroblasts;functional loss;Gene Expression;Gene Expression Regulation;Gene Proteins;Genes;Goals;Golgi Apparatus;Guidelines;Heart;heart damage;Heart Diseases;Heart failure;Heart Injuries;improved;In Vitro;in vivo;Infarction;innovation;Ischemia;Knowledge;Label;Link;Mediating;Membrane;Membrane Proteins;Messenger RNA;Metabolism;Molecular;mouse model;mRNA Stability;mRNA Translation;Mus;Myocardial Infarction;Myocardium;novel;optimal treatments;Organelles;Pathway interactions;Population;Post-Transcriptional Regulation;postnatal development;prevent;Production;programs;Protein Biosynthesis;protein expression;protein folding;Protein Secretion;Proteins;Recommendation;Regulation;Regulator Genes;Rejuvenation;Reperfusion Therapy;response;response to injury;ribosome profiling;Ribosomes;RiboTag;RNA;RNA metabolism;RNA-Binding Proteins;Role;Rough endoplasmic reticulum;secretory protein;Secretory Vesicles;Structure;Therapeutic;Transcript;Transcriptional Regulation;Up-Regulation

PROJECT_TITLE: Post-Transcriptional Regulation of Gene Expression by Ribosome-Binding Protein 1

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Genetics;Neurosciences;Pain Research;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: NARRATIVE The results of the proposed research will significantly enhance understanding of the molecular mechanisms underlying sensory neuron responses after peripheral injury in neonates and provide novel information for use in the development of new avenues of research and therapies for post-surgical pain in children. The information obtained from these innovative studies will allow us to better understand the functional implications of how cellular memories regulate sensory neuron function and the role they play in the advancement of pediatric pain states.

PI_NAMEs: JANKOWSKI, MICHAEL P (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Ablation;Acute;Adolescent;Adult;Afferent Neurons;Anatomy;Anti-Inflammatory Agents;ATAC-seq;behavior test;Behavioral;Behavioral Assay;Biological Assay;Calcium;Cells;Central Nervous System;Child;Childhood;Chronic;chronic pain;cohort;Communication;Culture Media;cytokine;Data;Development;epigenetic memory;Epigenetic Process;experience;experimental study;Gene Deletion;Gene Expression;Genes;Genetic;genetic manipulation;Goals;Growth Factor;human induced pluripotent stem cells;Hypersensitivity;Image;Immune;Immune system;Immune Targeting;Immunity;immunocytochemistry;immunoregulation;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Infiltration;Inflammatory;inflammatory milieu;injured;Injury;innovation;insight;Interleukins;knock-down;Knock-out;Life;Link;Long-Term Effects;Macrophage;mast cell;Mechanics;Mediating;Memory;Modification;Molecular;Mus;Muscle;Neonatal;neonatal injury;neonate;Nerve;Nerve Growth Factors;Nervous System;Neuroimmune;Neurons;NGFR Protein;Nociception;nociceptive response;novel;Operative Surgical Procedures;Outcome;Pain;Pain management;Parvalbumins;Peripheral;Peripheral Nervous System;Persistent pain;Phenotype;Physiological;Play;postnatal;Postoperative Pain;Preparation;Production;Protein Array;Proteins;Reaction;Reporting;Research;response;Role;Signal Transduction;Small Interfering RNA;somatosensory;Somatotropin;Source;Spinal Cord;Structure of tibial nerve;Surgical incisions;System;Testing;Time;Tissues;Training;transcriptional coactivator p75;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;Translating

PROJECT_TITLE: Sensitization of developing sensory neurons after incision

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Physical Activity

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE One of the ways that osteocytes, cells embedded within bone, support skeletal health is by maintaining bone quality. An improved understanding of how osteocytes respond to stimuli, like exercise, to support bone quality will improve the success of clinical efforts to prevent bone fragility in aging or disease. Here we test the hypothesis that exercise directs changes in bone quality by modulating osteocyte cellular metabolism and remodeling of the matrix surrounding the osteocyte.

PI_NAMEs: ALLISTON, TAMARA N (contact);KOHN, DAVID H.

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Ablation;Aging;Animal Genetics;Animal Model;Biological;bone;Bone Density;bone fragility;bone loss;Bone Matrix;bone quality;Bone structure;Calibration;Cells;Clinical;Collagen;collagenase 3;cortical bone;Coupled;Data;Defect;Dependence;Diabetes Mellitus;Diagnostic;Disease;disease model;Enzymes;Exercise;Extracellular Matrix;Extracellular Matrix Proteins;Fracture;Functional disorder;Gene Expression;Genes;Genetic;Genetic Models;Health;Image;Impairment;improved;In Vitro;insight;Knowledge;Laboratories;Length;Machine Learning;Maintenance;materials science;Measures;mechanical properties;Mechanics;Metabolic;metabolic imaging;Metabolism;Microfluidics;Mitochondria;Modeling;Molecular;Monitor;mouse model;multimodal data;Mus;nanoindentation;novel;novel strategies;Osteocytes;Outcome;pharmacologic;Physical activity;Physiological;Play;Positioning Attribute;Post-Translational Protein Processing;prevent;Process;Property;protein expression;Proteome;proteomic signature;Proteomics;receptor;Resistance;Role;Signal Transduction;skeletal;Skeleton;SOD2 gene;spatiotemporal;Stimulus;Structure;success;System;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic candidate;Time;timeline;transcriptome;Transforming Growth Factor beta;Vulnerable Populations;Work

PROJECT_TITLE: Osteocytic mechanisms required for spatiotemporal control of bone quality

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: EDINBURG

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

ORG_STATE: TX

PHR: PROJECT NARRATIVE Patients with severe Hemophilia A (HA) experience frequent bleeding—often spontaneously—because they inherit an X-chromosome from their mother that has a mutation in the gene which makes a critical blood clotting protein called factor VIII (FVIII). As a result, they don’t make any (or only very little) of this essential blood clotting protein. Thus, bleeding in severe HA-patients (HAPs) is currently prevented by regular infusions of a therapeutic (t) FVIII protein (tFVIII) product. Unfortunately, ~30% of all severe HAPs develop antibodies called “FVIII inhibitors (FEIs)”, which neutralize tFVIIIs and greatly increase morbidity and mortality. FEIs develop in ~40-45% of severe HAPs with Mexican ancestry (MA) but in only ~20-25% of those with European ancestry. This research, which we refer to as the “Trans-omics for FVIII Inhibitor Causation (TRAFFIC)” study, seeks to identify genetic and environmental variables that underlie the high incidence of FEIs in HAPs with MA.

PI_NAMEs: ESCOBAR, MIGUEL ;HOWARD, TOM EUGENE (contact);WILLIAMS-BLANGERO, SARAH A.

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Age;Alleles;Antibodies;Antigens;Binding;bioinformatics tool;Biological Assay;Biological Markers;Blood coagulation;Blood Coagulation Disorders;Blood specimen;Brothers;CD4 Positive T Lymphocytes;Cells;Classification;Clinical;Clinical Data;clinically relevant;cohort;Collaborations;Collection;Complex;CRISPR/Cas technology;cross reactivity;Data;Dendritic Cells;Development;Diagnostic;Distant;endophenotype;Enrollment;Environmental Risk Factor;enzyme linked immunospot assay;enzyme replacement therapy;ethnic disparity;Etiology;European ancestry;experience;Factor Analysis;Factor VIII;Future;Genes;Genetic;genetic approach;Genomics;health disparity;Hemophilia A;Hemorrhage;high dimensionality;Hispanic Americans;Immune response;immunogenic;immunogenicity;Immunologic Epidemiology;Immunologics;improved;In Vitro;Incidence;Individual;Infusion procedures;Inherited;inhibitor;Knock-out;Life;Link;Liquid Chromatography;Measures;Medical History;Methods;Mexican;Mexican Americans;Mexico;Minority Groups;Morbidity - disease rate;mortality;Mothers;mRNA sequencing;Mutation;non-genetic;Not Hispanic or Latino;novel;Outcome;Participant;Patient Recruitments;Patients;Peptides;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;prevent;proband;Process;Prophylactic treatment;Proteins;Proteomics;Quantitative Genetics;Race;Recombinants;Recording of previous events;recruit;repository;Research;Resources;Risk;Safety;Sampling;Signal Transduction;Socioeconomic Status;standard of care;T-Lymphocyte;tandem mass spectrometry;Testing;Therapeutic;trait;transcriptome;transcriptomics;treatment center;Treatment Efficacy;Underrepresented Minority;underserved minority;Variant;whole genome;X Chromosome

PROJECT_TITLE: Omic Approaches to Factor VIII Inhibitor Development in Hemophilia Patients of Mexican Descent

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Nutrition;Obesity;Prevention

PHR: PROJECT NARRATIVE This project uses advanced methods in neuroimaging and machine learning to test whether individuals with overweight or obesity and high craving can learn to modulate their brain response to food cues using neurofeedback, to impact their craving and eating behavior. This project will improve our understanding of food cue-reactivity and craving and will inform a larger planned trial to study the effects of this approach on overweight and obesity treatment outcomes. Helping individuals with overweight and obesity learn skills to cope with craving to potentially improve their health could have a significant impact on reducing disease burden and improving public health.

PI_NAMEs: GARRISON, KATHLEEN A. (contact);SCHEINOST, DUSTIN

PROGRAM_OFFICER_NAME: WOO, THERESA TESLOVICH

PROJECT_TERMS: Address;Adult;Behavior;Biological Markers;Brain;Brain region;burden of illness;cardiovascular risk factor;Cessation of life;Clinical;clinical biomarkers;Clinical Trials;cognitive process;Complex;connectome;connectome based predictive modeling;Consummatory Behavior;coping;cost;craving;cue reactivity;Cues;Data;Diagnostic;Disease;Eating;Eating Behavior;Environment;Etiology;feasibility testing;Feedback;follow-up;Food;food craving;Functional Magnetic Resonance Imaging;Health;improved;Individual;Informal Social Control;innovation;inter-individual variation;Lead;Learning;Learning Skill;Link;Machine Learning;Measures;Methods;Morbid Obesity;Motivation;neurofeedback;neuroimaging;novel strategies;Obesity;Obesity Epidemic;obesity treatment;obesogenic;Overweight;personalized medicine;Pharmaceutical Preparations;Phenotype;predictive marker;predictive modeling;premature;Prevalence;Prevention;Probability;Public Health;Randomized;Research;response;Rest;Running;Scanning;Signal Transduction;Smoking;success;Symptoms;Testing;Therapeutic;Time;tool;Training;Treatment outcome;treatment response;trial planning;Visual;Weight Gain;Work

PROJECT_TITLE: Connectome-based neurofeedback of the craving network to reduce food cue-reactivity

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

PHR: Project Narrative Obtaining high quality pediatric brain MRIs with gadolinium (Gd) injection takes long (20+ minutes) time, and often necessitates sedation or anesthesia, which hinders normal brain development and poses increased risk for cognitive and behavioral problems later in life. We propose synergistic data acquisition, image reconstruction and deep learning enhancement strategies that improve pediatric brain imaging by enabling at most 5-fold reduction in Gd injection dosage and 3-fold acceleration of the typical pediatric brain MRI protocol. We aim to develop, validate and translate this imaging technology in clinical settings, thus enabling faster and safer pediatric brain exams with the potential to completely obviate the need for sedation or anesthesia and significantly reduce the dosage of Gd injections given during an MRI exam.

PI_NAMEs: BILGIC, BERKIN ;GAGOSKI, BORJAN  (contact);GRANT, PATRICIA ELLEN

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: 3-Dimensional;6 year old;Acceleration;Address;Adopted;Adoption;Adult;age group;Algorithms;Anesthesia procedures;Brain;Brain imaging;brain magnetic resonance imaging;Brain Neoplasms;Characteristics;Child;Childhood;Childhood Brain Neoplasm;Clinical;clinical examination;Cognitive;cognitive development;Computer software;Computers;contrast enhanced;contrast imaging;Contrast Media;cost;Data;data acquisition;deep learning;deep learning algorithm;deep learning model;denoising;Deposition;Development;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;dosage;Dose;economic impact;Functional Magnetic Resonance Imaging;Gadolinium;Health;Heavy Metals;Image;Image Enhancement;image reconstruction;Imaging technology;improved;Injections;innovation;Lanthanoid Series Elements;Life;Magnetic Resonance Imaging;Metal exposure;Monitor;Morphologic artifacts;Motion;neurotoxic;new technology;Noise;novel;pediatric patients;Phase;Population;Predisposition;Preparation;Problem behavior;Protocols documentation;radiologist;Recommendation;reconstruction;Renal function;Resolution;Risk;Scanning;Sedation procedure;sedative;Slice;Speed;structural imaging;Techniques;Technology;Testing;Time;tool;Training;Translating;treatment response;tumor;tumor diagnosis;two-dimensional;ultra high resolution;Vendor;Vulnerable Populations

PROJECT_TITLE: Low-dose contrast enhanced fast pediatric brain MRI

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Kidney Disease

ORG_CITY: BLACKSBURG

ORG_DEPT: CHEMISTRY

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE In this research project, we will test whether inhibiting the sphingosine-1-phosphate pathway at either the point of synthesis (sphingosine kinase 2) or transport (Spns2) is useful in slowing the progression of kidney fibrosis, which is an important component of chronic kidney disease pathology. To date, there are no effective medicines to stop, or even slow, the fibrotic process. The goal of this program is to validate SphK2 and Spns2 inhibitors as experimental anti-renal fibrosis agents.

PI_NAMEs: LYNCH, KEVIN R.;SANTOS, WEBSTER L (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Adriamycin PFS;Albuminuria;Alleles;Animal Model;Anti-Inflammatory Agents;Attenuated;Binding;Biological Availability;Biology;Blood;Blood Vessels;Cardiovascular Diseases;cardiovascular risk factor;Chemicals;Chronic;Chronic Care;Chronic Kidney Failure;Cicatrix;Clinic;Clinical;Clinical Trials;Collagen;cost;Creatinine;Deposition;Development;Dose;Drug Kinetics;drug-like compound;edg-1 Protein;efficacious treatment;efficacy evaluation;efficacy study;efficacy validation;End stage renal failure;endothelial dysfunction;Endothelium;Environment;Epithelial Cells;Erythrocytes;extracellular;Extracellular Matrix;Extracellular Space;fibrosing agent;Fibrosis;Folic Acid;G-Protein-Coupled Receptors;genetic manipulation;Glomerular Filtration Rate;Goals;Guanidines;Health system;Heart Diseases;Hemodialysis;Homologous Gene;Hypertension;Hypoxia;improved;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;Inflammatory Response;inhibitor;innovation;Inorganic Phosphate Transporter;interstitial;Investigational Therapies;Kidney;Kidney Diseases;kidney fibrosis;Lead;Medicare;Medicine;Modeling;Modification;mouse model;Mus;novel therapeutics;Obesity;Oral;Oral Administration;Organ;Oxygen;Pathology;Pathway interactions;Patient Care;Patients;Pericytes;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;Phosphotransferases;Plasma;Positioning Attribute;pre-clinical;Process;Prodrugs;programs;Property;Protein Isoforms;Proteins;Regimen;Renal function;renal ischemia;Renal Replacement Therapy;Reperfusion Injury;Reperfusion Therapy;Reporting;Research Personnel;Research Project Grants;response;scaffold;screening;side effect;Signal Transduction;small molecule inhibitor;Source;Sphingosine;sphingosine 1-phosphate;sphingosine kinase;sphingosine-1-phosphate lyase;Sphingosine-1-Phosphate Receptor;synergism;Testing;Therapeutic;Tissues;Toxic effect;Translating;Translations;Transplantation;Tubular formation;Ureteral obstruction;Work;wound;wound healing

PROJECT_TITLE: Blockade of S1P pathway for renal fibrosis therapy

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cardiovascular;Genetics;Physical Activity;Prevention

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Here we propose measurements of molecules that are carried by small vesicles in the circulation delivering potential beneficial effects. We also are measuring quantitative metabolites which can offer evidence of exercise benefits and other therapeutic agents potentially carried by the small vesicles in the circulation.

PI_NAMEs: LANZA, IAN R;NAIR, K SREEKUMARAN  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Acute;acylcarnitine;Adipose tissue;Aerobic Exercise;Age;animal tissue;Animals;Biochemical Pathway;Biological;Biological Assay;Biological Markers;Biology;Blood Plasma Volume;Chemicals;Child;Chronic;Circulation;Citric Acid;Citric Acid Cycle;Clinic;clinical center;clinical research site;cohort;Collaborations;Complement;COVID-19;Data;Data Analyses;Data Set;Exercise;exercise program;exercise training;Exhibits;exosome;experimental study;Fingerprint;Funding;Genetic Transcription;Human;innovation;insight;Label;Laboratories;Measurement;Measures;men;metabolome;metabolomics;Methodology;MicroRNAs;mode of exercise;Molecular Analysis;Molecular Profiling;Molecular Sieve Chromatography;Monitor;multiple omics;Muscle;nano-string;novel;Nucleic Acids;Organ;organic acid;Participant;Pathway interactions;Pattern;Persons;Physical activity;Physiological;Plasma;Plasma Proteins;preclinical study;Protein Biosynthesis;protein profiling;Proteins;Proteome;Proteomics;Radioisotopes;Recovery;Reproducibility;Research Activity;resistance exercise;response;Sampling;sedentary;sex;Site;Skeletal Muscle;Sphingolipids;Testing;Therapeutic Agents;Time;Tissue Sample;Tissues;Training Programs;transcriptome sequencing;translational potential;Ultracentrifugation;United States National Institutes of Health;Vesicle;Woman;working group

PROJECT_TITLE: Mayo Clinic Physical Activity Research Center: Metabolomics and Proteomics Analysis Site

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-A (51)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DALLAS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE The proper function of several vital organs in humans requires the activity of cilia and defects in ciliary assembly and motility are responsible for a wide variety of life-threatening genetic disorders, such as chronic respiratory disease, congenital heart disease, brain developmental defects, and primary ciliary dyskinesia. Using innovative methods, our work addresses fundamental questions about how the activity of dynein motors is regulated and coordinated to give rise to the normal movement of cilia. We expect that this research will provide new insights into the underlying mechanisms of ciliary-linked disorders (ciliopathies) in humans, which is a prerequisite to the development of therapeutic interventions.

PI_NAMEs: NICASTRO, DANIELA  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Address;arm;ATP Hydrolysis;ATPase Domain;Binding;Brain;Cell division;Cell Maintenance;cell motility;chronic respiratory disease;Cilia;ciliopathy;cilium motility;Classification;comparative;Complex;Congenital Disorders;congenital heart abnormality;Cryo-electron tomography;Cryoelectron Microscopy;Cytoskeleton;Data;Defect;Development;Disease;Dynein ATPase;Esthesia;Eukaryotic Cell;Flagella;Generations;Genetic Diseases;Goals;Handedness;Heterogeneity;Human;Image;imaging approach;Individual;Infertility;innovation;insight;Left;Length;Life;light microscopy;Link;Liquid substance;Location;Maps;Mass Spectrum Analysis;Methods;Microtubules;Modeling;Modernization;Molecular;Molecular Conformation;Motility;Motor;Movement;Multiprotein Complexes;Mus;mutant;Mutation;nexin;Organ;Organelles;particle;Play;Primary Ciliary Dyskinesias;Process;Protein Isoforms;Proteins;Proteome;Publishing;Radial;Randomized;Regulation;Research;Resolution;respiratory;Role;Signal Pathway;Signal Transduction;Slide;spatiotemporal;Structural defect;Structure;Testing;therapeutic development;Therapeutic Intervention;three dimensional structure;Tissues;Visualization;Work

PROJECT_TITLE: Structure and Function of Complexes that Regulate Ciliary Motility

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: TR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: IRVINE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: NARRATIVE Understanding how hormones are regulated is crucial for advancing the treatment of endocrine diseases. Many hormones are released in pulses, rather than continuously, but reproducing this pulsatile environment in the lab is challenging. This project will develop a microfluidic platform that can mimic the natural pulsatile secretion of hormones, allowing scientists to study their regulation and develop new therapies.

PI_NAMEs: HUI, ELLIOT E (contact);NICHOLAS, DEQUINA ANGELINA

PROGRAM_OFFICER_NAME: KANG, KIHWA

PROJECT_TERMS: analog;Animal Model;Back;behavior change;Biological;biological systems;Biology;Bite;blood glucose regulation;Cell Culture System;Cell Culture Techniques;Cell Line;cell type;Cells;Clinical;Collection;Communities;Complex;Culture Media;culture plates;design;Devices;Disease;drug development;effective therapy;Endocrine;Endocrine Physiology;Endocrine system;Endocrine System Diseases;Environment;falls;Follicle Stimulating Hormone;Formulation;Frequencies;gender dysphoria;Goals;Gonadotropin Hormone Releasing Hormone;Growth;Hormonal;hormone regulation;Hormone secretion;Hormones;Hour;Hydrocortisone;improved;In Vitro;Infertility;Infusion procedures;insulin secretion;Intervention;Investigation;Laboratories;Logic;Luteinizing Hormone;Malignant neoplasm of prostate;Melatonin;Methods;Microfluidics;Molecular;Monitor;novel;novel therapeutics;Patient Care;Pattern;Periodicals;Periodicity;Physiologic pulse;Physiological;Pituitary Gland;preclinical study;Preclinical Testing;Precocious Puberty;Process;Production;Pump;Regulation;Reproducibility;Reproducibility of Results;Reproduction;reproductive hormone;Research;response;Rest;Route;sample collection;Sampling;Scheme;Scientist;Shapes;Somatotropin;Source;System;Systems Integration;Technology;Therapeutic;therapeutic development;Therapeutic Intervention;Time;tool;Translations;Uterine Fibroids;validation studies;Variant

PROJECT_TITLE: Autonomous Platform for Pulsatile Soluble Stimulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-G (80)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: SANTA BARBARA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Eye movements are fundamental to understanding vision and cognition and their dysfunctions. We aim to create a model with human-like vision, language, and scene understanding that can search like humans for an object in a never-seen real-world image. The tools and framework developed could pave a new path in the study of eye movements and for theoretical functional assessment of visual and cognitive deficits in natural search tasks.

PI_NAMEs: ECKSTEIN, MIGUEL PATRICIO (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: active vision;Architecture;Area;Attention;Behavior;Behavioral;Cognition;Cognitive deficits;Computer Models;convolutional neural network;deep neural network;Detection;detector;Development;disabled;Eye Movements;frontal eye fields;Functional disorder;gaze;Goals;Human;human model;Image;Impaired cognition;information gathering;Instruction;Intention;Investigation;Language;Language Development;large language model;Learning;Linguistics;Location;Maps;Modeling;neural;Neurons;next generation;Object Attachment;oculomotor;Performance;pre-trained transformer;Property;Psychological reinforcement;Research;Research Personnel;sample fixation;Sampling;Semantics;Task Performances;Testing;Theoretical model;tool;Training;Vision;Vision Disorders;Visual;visual dysfunction;visual information;visual search;Visual System;Weight;Work

PROJECT_TITLE: Foveated Search Model for Real World Scenes

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Lung;Neurodegenerative;Neurosciences;Prevention;Rare Diseases;Sleep Research

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy and is two to four times as common as sudden infant death syndrome (SIDS). Inhibition of serotonin neurons by seizures may impair the body’s ability to regulate breathing, autonomic function, and arousal during a vulnerable period. The proposed research is relevant to public health and the NIH’s mission because a better understanding of how inhibition of CO2 chemoreception by seizures causes respiratory depression, autonomic dysfunction, and impaired arousal is expected to lead to the identification of novel candidate biomarkers for SUDEP risk and to the development of new preventive treatments for SUDEP.

PI_NAMEs: GEHLBACH, BRIAN ;RICHERSON, GEORGE B (contact)

PROJECT_TERMS: Abdomen;Acute;Admission activity;Affect;Air Movements;Amygdaloid structure;animal data;Animals;Apnea;Arousal;Attenuated;Autonomic Dysfunction;Awareness;Biological Markers;Blood gas;Blood Pressure;Body Temperature;Breathing;candidate marker;Carbon Dioxide;Cardiac;Cardiovascular Physiology;Cardiovascular system;Cause of Death;Cessation of life;Chemoreceptors;Chest;Conscious;Dangerousness;Data;Defect;Development;Electrocardiogram;Electroencephalography;Epilepsy;Event;experience;falls;Feedback;Functional disorder;Goals;Heart Arrest;heart rate variability;high risk;Homeostasis;Hour;Human;human data;Hypercapnia;Hypoventilation;Impairment;Inhalation;innovation;Intractable Epilepsy;Knowledge;Laboratories;Lead;Life;Link;Measures;Mental Depression;Methods;Mission;Monitor;Motor Seizures;Neuronal Dysfunction;Neurons;Nose;novel;novel marker;Outpatients;Output;Patient Admission;patient subsets;Patients;pH Homeostasis;Pressure Transducers;prevent;Preventive treatment;Prosencephalon;Public Health;Pulse Oximetry;Recovery;Reflex action;Research;respiratory;Respiratory physiology;response;Risk;Risk Factors;Role;Seizures;Serotonin;Severities;Sleep;Stimulant;Sudden infant death syndrome;sudden unexpected death in epilepsy;Testing;Time;Tonic - clonic seizures;United States National Institutes of Health;ventilation;Ventilatory Depression;Work

PROJECT_TITLE: Inhibition of central CO2 chemoreception by seizures: Effects on ventilation, cardiovascular control and postictal recovery of consciousness

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Different kinds of cells in the body express different genes from the genome, because they not only express different gene regulating proteins (transcription factors), but also pack the genes in their nuclei in different ways that make certain genes easier or harder for the regulatory proteins to reach. It is still poorly understood how to predict how the regulatory proteins distribute their influence among different genes, and how to predict when these regulatory proteins will prevail in reaching a particular target gene. This proposal is to shed light on the underlying rules needed to determine these predictions, focusing on cells in early stages of becoming immune- system T cells.

PI_NAMEs: ROTHENBERG, ELLEN V. (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Affinity;Appearance;Architecture;Atlases;Binding;Binding Sites;Biophysics;Cell Nucleus;Cells;Chromatin;Compensation;Data;Development;differentiation in vitro;DNA Binding Domain;Elements;Eligibility Determination;Enhancers;Epigenetic Process;epigenome;epigenomics;experimental study;Family;Family member;Future;Gene Expression;Gene Expression Regulation;gene network;Generations;Genes;Genetic;genetic regulatory protein;Genome;genome-wide;Genomics;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Immune system;in vivo;Inherited;Ligand Binding Domain;Link;Lymphocyte;Lymphoid;Measures;Megakaryocytes;Mutation;notch protein;Pathway interactions;Pattern;Play;premature;programs;protein expression;Proteins;Regulation;Role;RUNX3 gene;Signal Transduction;Site;Speed;System;Systems Development;T-Cell Development;T-Lymphocyte;Tertiary Protein Structure;Testing;Time;tool;transcription factor;Work

PROJECT_TITLE: PROBING CONTROL OF DEVELOPMENTAL EPIGENETIC CHANGE USING RUNX FACTORS

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke;Telehealth

PHR: Project Narrative  High doses of intensive rehabilitation therapy can reduce disability after stroke, but most people do not receive this for reasons that include limited access and low motivation. We have found that a 6-week course of intensive home-based telerehabilitation focused on arm movement after stroke improves arm function and reduces overall disability. The currently proposed clinical trial will definitively establish the value of this treatment approach, evaluate an imaging-based measure of stroke injury that is useful for anticipating individual benefits from intensive rehabilitation therapy, and evaluate the health economic impact of home- based telerehabilitation in patients with recent stroke.

PI_NAMEs: CRAMER, STEVEN C. (contact);EDWARDS, DYLAN JAMES

PROGRAM_OFFICER_NAME: AFZAL, MARIAM MASHEEB

PROJECT_TERMS: Achievement;actigraphy;Action Research;Address;arm;arm function;arm movement;Biological Models;blind;Brachial Paresis;Brain;Caregiver Burden;Caring;Clinic;Clinical;clinical practice;Clinical Trials;comparative efficacy;comparison group;Control Groups;Corticospinal Tracts;disability;disease heterogeneity;Dose;economic evaluation;economic impact;economic outcome;Efferent Pathways;Exclusion;functional improvement;functional outcomes;Future;Health Care Costs;health care service utilization;health economics;health related quality of life;Home;Image;imaging biomarker;improved;improved outcome;Individual;Injury;Intervention;Licensing;Magnetic Resonance Imaging;Measures;Mediation;Medical;mortality;Motivation;Motor;motor deficit;motor rehabilitation;Movement;multi-site trial;Occupational Therapist;Outcome Measure;Patient Selection;Patient-Focused Outcomes;Patients;Persons;Phase;phase II trial;physical therapist;post stroke;Prediction of Response to Therapy;preservation;primary outcome;programs;Quality of life;Randomized;randomized trial;Recovery;recruit;Rehabilitation therapy;Reporting;Research;secondary outcome;Site;Stroke;stroke recovery;stroke survivor;StrokeNet trials;System;targeted treatment;telehealth;telerehabilitation;Testing;Therapeutic;Time;Travel;treatment as usual;treatment group;trial comparing;United States;Upper Extremity;Validation;videoconference;white matter;Work

PROJECT_TITLE: Telerehabilitation In The Home After Stroke: A Randomized, Controlled, Assessor-Blind Clinical Trial (The TR-2 Trial)

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (20)]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: Project Narrative Understanding how signal transduction pathways drive specific genetic circuits is a fundamental goal of biology. The thousands of dynamic signaling events and gene expression changes that occur upon cell stimulation have made linking these two processes challenging. Here, we propose a novel, interdisciplinary analytical framework to link gene expression programs to specific phosphorylation events using genome-wide data with the goal of expanding strategies for therapeutic intervention.

PI_NAMEs: GOTTSCHALK, RACHEL A;MYERS, SAM ANTHONY (contact)

PROJECT_TERMS: Anti-Inflammatory Agents;base editing;Biological Assay;Biological Models;Biological Process;biological systems;Biology;cell behavior;Cell Physiology;Cells;cellular targeting;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;Communicable Diseases;Comprehension;computer framework;Computer Models;Coupling;cytokine;Data;Data Set;Decision Making;Disease;drug development;Evaluation;Event;Exploratory/Developmental Grant;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;genome-wide;Goals;Health;improved;Individual;Inflammation;Inflammatory;innovation;Interleukin-10;Interleukin-6;Janus kinase;Link;Macrophage;Malignant Neoplasms;Measures;Mediating;Methods;Modeling;mutant;Mutate;novel;Pathway interactions;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Phosphotransferases;Post-Translational Protein Processing;predictive test;Process;programs;Repression;response;Shapes;Signal Induction;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Specificity;STAT protein;Statistical Models;Stimulus;Technology;temporal measurement;Testing;therapeutic development;Therapeutic Intervention;tool;transcription factor;transcriptomics

PROJECT_TITLE: Linking specific phosphorylation events to distinct transcriptional states

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: EH

IC_NAME: NATIONAL CENTER FOR ENVIRONMENTAL HEALTH

ORG_CITY: ST. PAUL

ORG_NAME: MINNESOTA STATE DEPT OF HEALTH

PHR: EHS-Net Food Safety Project Narrative Foodborne illness has been, and continues to be, a tremendously important public health problem in Minnesota. Case-control studies have implicated eating at restaurants as a source of nonoutbreak-associated infections with several disease agents (e.g., Salmonella, Campylobacter, and E. coli O157:H7). These studies, along with the substantial burden of foodborne illness outbreaks associated with commercial food establishments, were primary reasons for the formation of the Environmental Health Specialist Network (EHS-Net). Foodborne outbreaks associated with commercial food establishments still occur commonly. In the last 20 years, EHS-Net has made great strides in characterizing and publishing contributing factors and antecedents to foodborne illness in these establishments. The Minnesota Department proposes to synthesize completed EHS-Net work; conduct additional contributing factor and antecedent studies; and, develop, implement, and evaluate intervention studies at commercial food establishments.

PI_NAMEs: SMITH, KIRK  (contact)

PROJECT_TITLE: EH20-001, Environmental Health Specialists Network (EHS-Net) - Practice based research to improve food safety


ORG_CITY: MENANDS

ORG_NAME: NYSDOH/HEALTH RESEARCH, INC.

ORG_STATE: NY

PHR: Environmental Health Specialists Network (EHS-Net) – Practice Based Research to  Improve Food Safety in New York State RFA-EH-20-001 Project Narrative The New York State Department of Health (NYSDOH) has been a leader in protecting and advancing the health of New Yorkers through a comprehensive network of public health activities and services. The complexity of the state, from densely populated urban, to rural and suburban areas, the diversity of the state with respect to race, ethnicity, and socioeconomic status, warrants a public health system that is comprehensive and flexible to govern the state's public health successfully. The NYSDOH is seeking support for the Environmental Health Specialists Network (EHS-Net) – Practice Based Research to Improve Food Safety Cooperative Agreement.

PI_NAMEs: NICHOLAS, DAVID  (contact)

PROJECT_TITLE: RFA-EH-20-001 : Environmental Health Specialists Network (EHS-Net) - Practice Based Research to Improve Food Safety In New York State


ORG_CITY: HOUSTON

ORG_NAME: HARRIS COUNTY

PHR: Public Health Significance/Narrative The proposed research is relevant to public health because improving upon the surveillance and response of foodborne illness complaints, and prevention efforts to reduce future ones, has the effect of reducing potentially catastrophic foodborne illness outbreaks that can lead to significant human and economic loss. Thus, this proposal is relevant to the established CDC Food Safety Winnable Battle for Food Safety priority to discover high impact and innovative research strategies that will ultimately assist in preventing foodborne illness.

PI_NAMEs: MONROY, JOANN  (contact)

PROJECT_TITLE: EH20-001 - Strengthening Foodborne Illness Surveillance and Response Capabilities in Harris County Using an Innovative System-Based Approach


ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND STATE DEPT OF HEALTH

ORG_STATE: RI

PHR: Project Narrative: Rhode Island EHS-Net Practice Based Research to Improve Food Safety The researched proposed by the Rhode Island Department of Health (RIDOH), Center for Food Protection (CFP) will increase the knowledge in the scientific community regarding risk factors that contribute to foodborne illness and interventions to address those risk factors. More specifically, the studies aim to evaluate Norovirus interventions and prevention efforts, quantify the impact of having a Certified Manager on at all times, and identify best practices for environmental assessments. The research conducted under this funding opportunity will improve environmental health practices in retail food establishments and reduce illnesses and disabilities associated foodborne pathogens.

PI_NAMEs: VIVEIROS, BRENDALEE  (contact)

PROJECT_TITLE: EH20-001 Rhode Island EHS-Net Practice Based Research to Improve Food Safety


ORG_CITY: COLUMBUS

ORG_NAME: FRANKLIN COUNTY OHIO BOARD/COMMISSIONERS

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because a better understanding of how certified kitchen managers impact foodborne illness risk factors in food service operations and retail food establishments could improve food safety in these facilities. Additional collaboration on other EHS-Net projects could result in further advancements in environmental health practice. Thus, the proposed activities are relevant to the EHS-Net’s aim to develop a cross-cutting network of public health professionals that conduct practice- based retail food safety research to improve food safety.

PI_NAMEs: JENSEN, SARAH  (contact)

PROJECT_TITLE: EH20-001 - Franklin County Public Health practice-based research to identify and prevent environmental risk factors contributing to foodborne illness


ORG_CITY: LAS VEGAS

ORG_NAME: SOUTHERN NEVADA HEALTH DISTRICT

ORG_STATE: NV

PHR: Project Narrative Recent research has proposed that negative food safety culture be considered an emerging risk factor for foodborne illness outbreaks due to its significant impact on outbreaks (Griffith, Livesey, & Clayton, 2010a). SNHD proposes to explore food safety culture as experienced by food handlers and restaurant managers and share findings by creating resources geared toward restaurants. This study aims to foster positive food safety culture which may improve adherence to food safety practices, thereby potentially reducing foodborne illness transmission at the retail food establishment level.

PI_NAMEs: DIPRETE, LAUREN  (contact);SAXTON, CHRIS

PROJECT_TITLE: EH20-001 SNHD Food Safety Culture


ORG_CITY: NEW YORK

ORG_NAME: FUND FOR PUBLIC HEALTH IN NEW YORK, INC.

PHR: Project Narrative The NYC EHS-Net Program will use data and informatics tools to improve measurement and surveillance of foodborne illness risk factors in the NYC retail food service environment. We anticipate three outcomes associated with the work we propose: 1) faster and more accurate identification of risk factors, 2) interventions or policies that effectively address those risk factors and thereby reduce incidence of FBI, and 3) improved public health practice, including implementation of evidence-based food safety regulations and policy, distribution of effective educational resources to food service workers, and more efficient and effective inspectional programs.

PI_NAMEs: MCKELVEY, WENDY  (contact)

PROJECT_TITLE: Advancing Foodborne Illness Prevention and Outbreak Response in the New York City Retail Food Service Environment


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Drug Abuse (NIDA only);Natural Products;Pain Research;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative: Rates of cannabis use and Cannabis Use Disorder (CUD) are increasing among women; epidemiological reports document a telescoping effect where women transition from first use to CUD at a faster rate than men. To understand cannabis’s acute effects that underlie the accelerated trajectory to CUD observed in women, the proposed study will compare smoked cannabis’s dose-dependent, abuse-related effects between men and women and variables that underlie these sex-dependent differences, including pharmacokinetics of THC and menstrual cycle effects. Findings from these studies will be instrumental in establishing sex as a biological variable in the prevention, intervention, and treatment of CUD.

PI_NAMEs: COOPER, ZIVA D (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Absence of pain sensation;abuse liability;Acceleration;Acute;Address;Agonist;Analgesics;antinociception;Behavioral;Cannabinoids;Cannabis;Cannabis Abuse;cannabis self-administration;Chronic;Clinical Research;CNR1 gene;design;Development;Dose;Double-Blind Method;Drug Kinetics;Epidemiology;epidemiology study;Estradiol;Exhibits;Female;Frequencies;Gender;Human;Intervention;Investigation;Knowledge;Laboratories;Laboratory Animals;Laboratory Study;Light;male;marijuana smoker;Marijuana Smoking;marijuana use;marijuana use disorder;marijuana user;Medical;Medical Marijuana;men;Menstrual cycle;Pain;Participant;Pharmaceutical Preparations;Placebo Control;Placebos;Plasma;pre-clinical;preclinical study;prevent;Prevention;Progesterone;proliferative phase Menstrual cycle;prospective;Prospective Studies;Public Health;Rattus;Recreation;recruit;Report (document);Reporting;response;Risk;Self Administration;sex;sex as a biological variable;Sex Differences;Smoke;Smoking;Testing;Tetrahydrocannabinol;THC exposure;Treatment Efficacy;trend;volunteer;Woman

PROJECT_TITLE: Sex-dependent effects of cannabis: Assessing abuse-related and pharmacokinetic differences between men and women


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Women's Health Research

ORG_CITY: Los Altos

ORG_NAME: QUADRIGA BIOSCIENCES, INC.

PHR: PROJECT NARRATIVE  This project will test the safety and efficacy of Quadriga’s new small molecule drug, QBS72S, in a clinical trial of patients with triple-negative breast cancer (TNBC) with brain metastases (tumor cells that have spread to the brain). TNBC is the most aggressive subtype of breast cancer: almost half of all women with TNBC develop brain metastases, and those who do typically survive for only three to six months longer. If QBS-72S proves effective in treating brain metastatic TNBC patients, it will hold promise for treating patients with other brain metastatic cancers, including lung cancer and melanoma.

PI_NAMEs: RINGOLD, GORDON M (contact)

PROGRAM_OFFICER_NAME: BOZZA, WILLIAM PATRICK

PROJECT_TERMS: Adverse event;Affect;African American Women;Alkylating Agents;Amino Acid Transporter;Amino Acids;analog;Biological Sciences;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain tumor barrier;Brain;Breast Cancer Patient;cancer type;chemotherapeutic agent;Clinical Trials;commercialization;Data;design;Development;Diagnosis;Disease;Disseminated Malignant Neoplasm;DNA;Dose;drug development;Enrollment;Evaluable Disease;Foundations;Funding;Growth;Human;improved;In Vitro;indexing;intravenous administration;Length;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Maximum Tolerated Dose;Melanoma;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Central Nervous System;Modeling;Mus;Neoplasm Metastasis;neoplastic cell;Nervous System Physiology;Network-based;Normal tissue morphology;objective response rate;Operative Surgical Procedures;Participant;Patients;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Phase III Clinical Trials;phase III trial;Physicians;Population;preclinical study;preservation;primary endpoint;Process;Progression-Free Survivals;Quality of life;Radiation therapy;response;Safety;safety testing;secondary endpoint;Small Business Innovation Research Grant;small molecule;small molecule therapeutics;Systemic disease;Therapeutic;Therapeutic Intervention;therapy development;triple-negative invasive breast carcinoma;tumor;tumor growth;Universities;Woman;Xenograft Model;Xenograft procedure;young woman

PROJECT_TITLE: QBS10072S for the Treatment of Brain Metastatic Triple-Negative Breast Cancer


NIH_SPENDING_CATS: Genetics

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Narrative (Relevance to public health) The proposed research will contribute to elucidating the mechanisms of gene regulation involving nucleosomes and chromatin modifications. Results from this project will help develop diagnoses and treatments of the diseases and disorders associated with erroneous gene regulation such as various types of cancer and neurodegenerative diseases.

PI_NAMEs: LEE, TAE-HEE  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;Affect;Area;Biochemical;cancer type;centromere protein A;chromatin modification;Complex;Core Protein;Development;Diagnosis;Disease;DNA;DNA Methylation;ds-DNA;Enzyme Interaction;Enzymes;Eukaryota;Failure;Fluorescence;Fluorescence Resonance Energy Transfer;Gene Expression Regulation;Genes;Genetic;Goals;Histone Acetylation;Histones;improved;Investigation;leukemia;Methods;Methylation;Molecular;Molecular Conformation;Molecular Machines;Motion;Multienzyme Complexes;Neurodegenerative Disorders;Nucleosomes;Optics;Pathogenesis;Play;Process;programs;Public Health;Reporting;Research;RNA Polymerase II;Role;single molecule;structural biology;Structure;Sumoylation Pathway;System;tool;ultra high resolution;Variant

PROJECT_TITLE: Dynamics of DNA-histone interactions


NIH_SPENDING_CATS: Breast Cancer;Cancer;Skin Cancer;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Macrophages, a component of our immune system, have a paradoxical role in cancer – they can promote metastasis. We previously discovered that macrophages spill their internal contents into cancer cells during metastasis, but what is the functionally important information in the contents? We recently discovered that mitochondria are transferred, and we seek to answer how thieving even small amounts of mitochondria can drive big changes in cancer cell metastasis.

PI_NAMEs: ROH, MINNA  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Affect;Automobile Driving;Behavior;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;cancer cell;carcinogenesis;cell behavior;Cell Communication;Cell Physiology;Cell Proliferation;Cells;Coculture Techniques;Collaborations;Communication;Communities;Cues;Cytoplasm;Darkness;Development;Electron Microscopy;Event;Exhibits;experimental study;extracellular;Future;Generations;Global Change;Goals;Homeostasis;Human;imaging approach;Immune;Immune system;Immunotherapy;In Vitro;in vivo;Injections;knock-down;Lateral;light microscopy;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;Metabolic;Metastatic Melanoma;Mitochondria;Morphology;mouse model;Neoplasm Metastasis;neoplastic cell;Organelles;Pathway interactions;Phenotype;PIK3CG gene;Play;Population;Positioning Attribute;Primary Neoplasm;Process;Proliferating;Reactive Inhibition;Reactive Oxygen Species;receptor;Reporting;Resolution;Respiration;response;Role;Side;Signal Pathway;Signal Transduction;Signaling Molecule;Solid Neoplasm;Source;Stromal Cells;Structure;System;Testing;tumor;tumor microenvironment;Tumor-associated macrophages;tumorigenic;Utah;Visualization;Zebrafish

PROJECT_TITLE: Mitochondrial lateral transfer during metastasis

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Social Determinants of Health;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Alcohol consumption is a leading cause of death and disability in the United States. Requiring evidence-based health warnings on alcohol containers could inform consumers and reduce unhealthy alcohol consumption, but there is little data on how such warnings influence alcohol consumption. The proposed research will optimize evidence-based warnings about the health harms of alcohol consumption and evaluate their effectiveness at reducing alcohol consumption among regular alcohol consumers in the US.

PI_NAMEs: GRUMMON, ANNA H;HALL, MARISSA  (contact)

PROGRAM_OFFICER_NAME: PARASURAMAN, SARIKA RANE

PROJECT_TERMS: 2 arm randomized control trial;Accounting;Address;Adopted;Adult;Age;Alcohol consumption;alcohol risk;Alcohols;American;arm;authority;Back;Behavior;behavior influence;binge drinking;cancer type;Cause of Death;Cessation of life;Communication;Consumption;Data;design;Development;diaries;disability;Disease;drinking;Education;Effectiveness;Elements;Ensure;Equation;evidence base;Evidence based practice;experimental analysis;experimental study;Exposure to;Federal Government;Gender;Guidelines;Health;health warning;Home;hypertensive heart disease;Injury;innovation;insight;Interview;Label;Laboratories;Legal;Measures;Mediation;Mediator;men;Meta-Analysis;Methods;Modeling;Participant;Policies;Policy Making;primary outcome;Probability Samples;Product Labeling;Protocols documentation;psychologic;public policy on alcohol;Randomized;randomized trial;Recommendation;recruit;Research;Risk;Rotation;Sampling;secondary outcome;Side;Smoking;Speed;Subgroup;Surveys;Testing;Time;United States;Update;Visit;warning label;Woman;Work

PROJECT_TITLE: Informing alcohol policy: The impact of evidence-based alcohol warnings on consumption

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Dementia;Mental Health;Nanotechnology;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: To investigate the pathophysiology of postoperative delirium (POD) in the long run, we propose to establish a new animal model in aged nonhuman primates by simultaneously measuring behaviors, neurophysiological markers, and blood biomarker (tau and phosphorylated tau) levels. We will set up the model by testing whether a general anesthetic sevoflurane promotes delirium-like behaviors, cortical neural changes, and alterations in plasma phosphorylated tau concentrations, as compared to propofol. Successful completion of the proposed studies will lead to a NIH R01 application to further study the POD pathophysiology using this animal model and may ultimately guide future perioperative care for high-risk elderly patients.

PI_NAMEs: XIE, ZHONGCONG  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: 10 year old;Address;Age;Age-associated memory impairment;aged;Agonist;Altered Level of Consciousness;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's neuropathogenesis;Anesthesia procedures;Anesthetics;Animal Model;Animals;Attention;Behavior;behavior test;Behavioral;Biological Assay;Biological Markers;Blood;Characteristics;clinical investigation;Clinical Research;cognitive testing;Crossover Design;Data;Delirium;Dependence;Development;Dexmedetomidine;Electroencephalography;executive function;experimental study;Functional disorder;Future;gamma-Aminobutyric Acid;General anesthetic drugs;Hallucinations;high risk;Human;inattention;innovation;insight;Intervention;Intravenous Anesthetics;Investigation;Ketamine;Literature;Measurement;Measures;Mediating;Memory impairment;Modeling;Monkeys;multimodality;Mus;nanoneedle;Nanotechnology;Neocortex;neocortical;neural;Neuronal Injury;neurophysiology;Neurotransmitters;nonhuman primate;novel;older patient;Parietal Lobe;Patients;Perioperative Care;Plasma;postoperative delirium;Postoperative Period;Pre-Clinical Model;Prefrontal Cortex;Propofol;Recovery;Reporting;Research;Research Personnel;Research Project Grants;Risk;Rodent;Sampling;sevoflurane;Short-Term Memory;stereotypy;Surface;System;tau Proteins;tau-1;Tauopathies;Technology;Testing;Training;United States National Institutes of Health;Volatilization;Vulnerable Populations;Work;young adult

PROJECT_TITLE: A Nonhuman Primate Model for Postoperative Delirium and Working Memory Impairment

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Transplantation

ORG_CITY: SUDBURY

ORG_NAME: PIONEER NEUROTECH INC.

PHR: Project Narrative Nerve injuries with a gap to-be-crossed greater than 3cm generally require a graft to facilitate axonal regeneration across the space, and regeneration across larger gaps has very limited success. The Romero lab at UH has developed a combination of growth factors that can significantly enhance recovery of function. Here we propose to partner with Pioneer Neurotech to develop procedures and specifications to incorporate the growth factors into implantable devices.

PI_NAMEs: ROMERO-ORTEGA, MARIO IGNACIO (contact)

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Acceleration;Acute;Affect;Afferent Neurons;Allografting;Animal Model;Autologous;Autologous Transplantation;Axon;axon growth;axon regeneration;Biological;Biological Products;Cell Proliferation;Characteristics;Clinical;comorbidity;Conditioned Culture Media;Data;Detection;Devices;Disease;Distal;Encapsulated;Enzyme-Linked Immunosorbent Assay;Europe;fabrication;FDA approved;Fluorescence;Goals;Growth;Growth Factor;Histologic;Housing;Iatrogenesis;Image;implantable device;improved;In Vitro;in vivo;Injury;injury and repair;innovation;Laboratories;Lead;Legal patent;Length;loss of function;Mediating;Methods;Microfluidics;migration;motor recovery;Muscle;myelination;Natural regeneration;Nerve;nerve autograft;nerve gap;nerve injury;Nerve Regeneration;nerve repair;Neuregulins;Neuroma;neurotrophic factor;Operative Surgical Procedures;Pain;particle;Patients;Peripheral;peripheral nerve repair;Peripheral Nerves;Phase;poly(lactic acid);Polyglycolic Acid;Polymers;postnatal;Procedures;Process;Proliferating;Rattus;Recovery;Recovery of Function;regenerative;Regenerative capacity;release factor;remyelination;repaired;Reproducibility;Resources;response to injury;Role;Sampling;Schwann Cells;sciatic nerve;Sensory;Sepharose;Skin;Small Business Technology Transfer Research;Specific qualifier value;Speed;Spinal Ganglia;Structure;success;Surface;Surgeon;System;Techniques;Technology;Testing;Time;Tissues;Trauma;United States;Universities;Visualization;Work

PROJECT_TITLE: Controlled Gradient Release of Biologics: Enhanced Nerve Conduit for Long‐Gap Injury Repair


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Heart failure with preserved ejection fraction affects a majority of heart failure patients, its prevalence is rising, and there are few effective therapies. Most patients today are also very obese, and this has altered the syndrome, worsening its prognosis and underlying pathobiology. This program elucidates how obesity has changed HFpEF at fundamental biological levels, including heart metabolism, gene expression and epigenetics, regulatory proteins, and the motors that make hearts contract.

PI_NAMEs: KASS, DAVID ALAN (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Affect;African American;Animal Model;Benchmarking;Biological;Calcium;Cardiac;Cell Physiology;Citrates;Citric Acid Cycle;Clinical;Contracts;Dedications;Depressed mood;Diabetes Mellitus;Disease;effective therapy;EFRAC;Epigenetic Process;Etiology;Female;Fibrosis;flexibility;Fumarates;Gene Expression;Genes;genetic regulatory protein;glucose metabolism;Heart;Heart failure;heart metabolism;hemodynamics;Histone Acetylation;histone methylation;histone modification;Human;Hypertension;Hypertrophy;improved;insight;interest;Knowledge;lipid metabolism;Medical;Medicine;Metabolic;metabolic abnormality assessment;Metabolic syndrome;Metabolism;Microfilaments;Modeling;Molecular;Morbidity - disease rate;mortality;Motor;Muscle Cells;Myocardial;myocardial biopsy;Myocardial tissue;Myocardium;novel;obese patients;Obesity;Organ;Oxidative Phosphorylation;Patients;Performance;Phenotype;Physiology;Polyamines;preservation;Prevalence;Prognosis;programs;Proteins;Sarcomeres;Stress;Succinates;Syndrome;Testing;United States National Institutes of Health

PROJECT_TITLE: Intersection of Obesity and Heart Failure with Preserved Ejection Fraction


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: DAUPHIN ISLAND

ORG_NAME: MARINE ENVIRONMENTAL SCIENCES CONSORTIUM

ORG_STATE: AL

PHR: Project Narrative The goals of the proposed project include: Increased scientific exchanges between university faculty and staff and FDA scientists and staff; Increased educational opportunities for qualified students (graduate), staff members and faculty members in the Parties' laboratories, classroom and offices; Facilitation of joint meetings for education and research; Increased research collaborations between university faculty and staff and FDA scientists and staff; Increased research product outputs, including peer-reviewed publications, protocol development, and scientific presentations; Development of cooperative international activities including outreach; and Sharing of unique facilities and equipment for increased cost efficiencies for scientific endeavors.

PI_NAMEs: CARMICHAEL, RUTH  (contact)

PROGRAM_OFFICER_NAME: BURKHARDT, WILLIAM

PROJECT_TITLE: Food & Drug Administration (FDA) and MESC/Dauphin Island Sea Lab Collaboration


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE: Director’s Overview and Essential Characteristics Brian Druker, M.D., Center Director The OHSU Knight Cancer Institute has made numerous impactful contributions since its designation as one of the nation’s National Cancer Institute Cancer Centers in 1997. Accomplishments include establishing the paradigm of targeted cancer therapy, now referred to as precision medicine. Through the work supported by our Cancer Center Support Grant, we conduct cancer research that spans basic, clinical, and prevention and control and aims to improve outcomes for individuals in our catchment area and throughout the nation.

PI_NAMEs: COUSSENS, LISA M. (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Acceleration;Achievement;Advanced Malignant Neoplasm;Advisory Committees;anti-cancer research;anti-racism;Area;Atlases;Automobile Driving;Behavior;Blood Tests;Breast;Breast Cancer Detection;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;cancer genome;cancer prevention;Cancer Survivor;Catchment Area;Characteristics;Climate;Clinical;Clinical Cancer Center;clinical care;Clinical Trials;cohort;Collaborations;colon cancer screening;Colonoscopy;Colorectal;combat;Communities;community engagement;community organizations;Community Outreach;community partnership;Comprehensive Cancer Center;County;Dedications;design and construction;Detection;Development;diversity and inclusion;Doctor of Medicine;Drug resistance;drug sensitivity;Early Diagnosis;Education;Employee;Enrollment;Ensure;Equity;Evaluation;Event;Exercise;Extramural Activities;Funding;Genetic;Genetic Screening;Goals;Grant;Guidelines;Health;Hereditary Nonpolyposis Colorectal Neoplasms;Human;Human Papilloma Virus Vaccination;Immunotherapeutic agent;improved;improved outcome;Individual;Infrastructure;innovation;Institution;International;Intervention;investigator-initiated trial;Investments;Knowledge;Lead;Leadership;leukemia;leukemia/lymphoma;Lung;lung cancer screening;Malignant neoplasm of prostate;Malignant Neoplasms;meetings;Melanoma;member;Mission;Molecular Target;molecular targeted therapies;National Cancer Institute;NCI-Designated Cancer Center;next generation;Oncology;Oregon;Pancreas;pandemic disease;Patient-Focused Outcomes;Patients;Peer Review;Performance;Persons;Pilot Projects;population based;precision medicine;precision oncology;Prevention;Prevention strategy;Process;professional atmosphere;programs;Proteomics;Publications;Publishing;recruit;Reporting;Research;Research Personnel;Resource Sharing;Science;Screening for cancer;screening guidelines;Solid Neoplasm;Strategic Planning;symposium;Systems Biology;targeted cancer therapy;targeted treatment;Testing;The Cancer Genome Atlas;Tobacco use;Training;Training and Education;Training Programs;translational oncology;translational progress;Treatment Side Effects;treatment trial;Treatment-Related Cancer;Trust;tumor;Tumor Biology;tumor-immune system interactions;Tumor-infiltrating immune cells;Universities;Work

PROJECT_TITLE: OHSU Knight Cancer Institute

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: ROBERTS, MINDY  (contact)

PROJECT_TERMS: Accounting;Advisory Committees;Advisory Services;anti-cancer research;Appointment;Area;Budgets;Businesses;Cancer Center;Cancer Center Support Grant;Clinical;Clinical Research;Collaborations;commercialization;Communication;community engagement;Community Outreach;community research;Data Collection;Data Reporting;Databases;Development;Doctor of Medicine;Documentation;Early Diagnosis;education research;Ensure;Evaluation;Event;Faculty;Faculty Recruitment;Funding;Goals;Grant;Health;Human Resources;Information Technology;Institution;Leadership;Maintenance;Malignant Neoplasms;meetings;Monitor;Occupations;operation;Oregon;Outreach Research;Physician Executives;Pilot Projects;Play;Policies;Population;precision oncology;Preparation;prevent;Process;programs;Progress Reports;Publications;recruit;Reporting;Research Personnel;Research Training;research vision;Resource Sharing;Resources;Role;Science;Scientist;Services;Strategic Planning;Structure;success;System;Training and Education;Training Support;Universities;Vision

PROJECT_TITLE: Cancer Center Administration


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE In this Program Project, we investigate how psychosocial stress affects cardiovascular disease by interfering with leukocyte dynamics. Over the course of our Type-1 Program, we substantially contributed to knowledge about the links between stress and cardiovascular disease by identifying tissular, cellular, and molecular pathways that connect nervous, immune, and vascular systems. The successful completion of this renewal application will not only lay the foundation for unique (i) scientific insights in immune mechanisms that are regulated neurologically and drive cardiovascular disease development but also yield (ii) a forward-thinking approach to managing cardiovascular disease in individuals experiencing prolonged episodes of psychosocial stress and identify novel (iii) therapeutic targets and treatments.

PI_NAMEs: FAYAD, ZAHI A. (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Address;Affect;Atherosclerosis;Biology;Brain;Brain region;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Catecholamines;Cell Nucleus;Cell Physiology;Clinical;Clinical Research;Complex;Coronary heart disease;COVID-19 pandemic;data integration;Development;Disease;Epigenetic Process;Event;Evidence based intervention;experience;Foundations;Genetic;Goals;Hematopoietic System;Human;image translation;imaging modality;imaging study;Imaging Techniques;Immune;Immune system;Immunity;Immunologic Memory;Immunology;immunoregulation;in vitro Assay;in vivo imaging;Individual;Inflammatory;innovation;insight;Knowledge;Leukocytes;Link;Macrophage;Mediating;metabolic profile;Methods;Modeling;Molecular;monocyte;mouse model;multidisciplinary;Multimodal Imaging;Mus;Myeloid Cells;nanobiologic;nanotherapy;Nervous System;Neuroimmune;Neurologic;Neurosciences;new therapeutic target;novel;novel strategies;optogenetics;Pathway interactions;Patients;perceived stress;pre-clinical;Principal Investigator;programs;Psychiatry;Psychosocial Assessment and Care;Psychosocial Stress;Reaction;Research;Research Personnel;Residual state;Risk Management;social defeat;Stress;therapeutic target;Thinking;tool;Training;Vascular System

PROJECT_TITLE: Stress-induced immune reprogramming in cardiovascular disease


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer

PI_NAMEs: SHERECK, EVAN  (contact)

PROJECT_TERMS: anti-cancer research;Area;cancer diagnosis;cancer education;Cancer Patient;cancer therapy;career;career development;Caring;Catchment Area;Collaborations;Communication;Communities;Continuing Education;Databases;Dedications;design;Development;Discipline;Diverse Workforce;diversity and inclusion;Doctor of Medicine;Education;Employee;Ensure;Ethnic Origin;Evaluation;Faculty;Faculty Recruitment;Foundations;Gender Identity;Goals;graduate student;Grant;Health;Health Professional;High School Student;Human Resources;Immigration;improved;Individual;innovation;Investments;junior high school;K-12 student;Language;Leadership;Learning;Malignant Neoplasms;Medical Students;member;Mentorship;Mission;NCI Center for Cancer Research;Nurses;Oregon;Output;Patient Care;Patients;Pharmacists;Physicians;Population;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;Productivity;programs;Race;recruit;Reporting;Research;research and development;Research Assistant;Research Institute;Research Personnel;Research Training;Resource Sharing;Resources;Role;satisfaction;Science;Scientist;Sex Orientation;skills;Strategic Planning;Structure;Students;Thinking;Time;Training;Training Activity;Training and Education;training opportunity;Training Programs;Training Technics;undergraduate student;Underrepresented Populations;Universities;Voice;Work

PROJECT_TITLE: Cancer Research Training and Education Coordination


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Chronic lung allograft dysfunction (CLAD) is a progressive fibrosis of the airway and/or lung parenchyma that is the primary limiting factor for long-term survival after lung transplantation. During acute cellular rejection, recipient-derived T cells infiltrate the lung allograft, migrate to the airways where CLAD predominantly occurs, and persist within the transplanted lungs as long-lived tissue resident memory T cells (TRM). This research project investigates the role of alloreactive recipient derived TRM in the development of CLAD after lung transplantation and explores the impact of commonly used immune modulators on TRM persistence, phenotype, and function.

PI_NAMEs: SNYDER, MARK EUGENE (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acute;Affect;Airway Fibrosis;airway inflammation;alemtuzumab;Allografting;Anatomy;basiliximab;Biological Assay;Biopsy;Bronchiolitis;Bronchiolitis Obliterans;CD58 gene;Cell Communication;cell motility;Cells;Chronic;Circulation;Clonal Expansion;computerized tools;cross reactivity;Cyclosporine;Data;Development;Environment;Epitopes;experience;Failure;Flow Cytometry;Functional disorder;Genetic Transcription;Glucocorticoids;Human;Immune;Immunomodulators;Immunosuppressive Agents;improved;In Vitro;Incidence;Influenza;Inhalation;Injury;Intervention;Investigation;Lead;Lesion;Life;Lung;lung allograft;Lung Diseases;Lung Transplantation;Lymphocyte;Macrophage;Maintenance;Mediating;migration;Modeling;Modification;Morbidity - disease rate;mortality;Myelogenous;Myeloid Cells;Organ;Organ Transplantation;Outcome;pathogen;Pathologic;Pathology;Patients;Peptides;Perfusion;Phenotype;programmed cell death ligand 1;Pulmonary Fibrosis;Pulmonary Inflammation;Receptor Signaling;recruit;Research;Research Project Grants;retransplantation;Risk;Risk Factors;RNA;Role;screening;single-cell RNA sequencing;Site;Solid;Specificity;Structure of parenchyma of lung;Syndrome;T cell infiltration;T cell receptor repertoire sequencing;T memory cell;T-Cell Receptor;T-Lymphocyte;Therapeutic;Therapeutic immunosuppression;tissue resident memory T cell;Tissues;Transplant Recipients;Validation;Viral

PROJECT_TITLE: Tissue resident memory T cells and chronic lung allograft dysfunction

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Heart Disease;Nanotechnology

PROJECT_TERMS: Academic Medical Centers;Acceleration;Accountability;Adherence;Authorization documentation;Award;Bioinformatics;Biology;Biomedical Engineering;Biostatistics Core;Blood Vessels;Boston;Cardiology;Cardiovascular Diseases;Collaborations;Communication Programs;design;Educational process of instructing;empowerment;Engineering;Ensure;Environment;experience;Faculty;Feedback;General Hospitals;Goals;Human Resources;Image;imaging science;Immune;Immunology;Institution;International Aspects;Knowledge;Laboratories;Leadership;Learning;Massachusetts;medical schools;meetings;member;nanomedicine;Nanotechnology;National Heart, Lung, and Blood Institute;Neurosciences;New York;New York City;Principal Investigator;programs;Psychiatry;Psychology;Radiology Specialty;Recommendation;Research;Research Personnel;Research Project Grants;Resources;Schedule;Self-Examination;Site;skills;Stress;Students;teacher;translational goal;Translational Research;Universities

PROJECT_TITLE: Administrative Core


PI_NAMEs: WONG, MELISSA H. (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;anti-cancer therapeutic;Apoptotic;Area;Award;Basic Science;behavioral phenotyping;Benign;Biological Markers;Biological Models;Blood Vessels;Breast Cancer Model;Cancer Biology;cancer initiation;Catchment Area;cell behavior;Cell Communication;Cell Cycle Checkpoint;Cell Cycle Regulation;Cell Physiology;Cell Proliferation;Cells;Clinical;Collaborations;Colorectal Cancer;commercialization;community engagement;Community Outreach;Development;Direct Costs;Discipline;Disease;DNA;DNA Damage;DNA Repair;Doctor of Philosophy;Drug resistance;Early Diagnosis;Educational Curriculum;Educational process of instructing;Educational workshop;Enhancers;Environment;Epigenetic Process;equity, diversity, and inclusion;Evaluation;Evolution;Faculty;Foundations;Funding;Genetic;Genetically Engineered Mouse;Goals;graduate student;Grant;Heterogeneity;Home;Image Analysis;Immune;In Vitro;in vivo Model;innovation;insight;inter-institutional;Inter-tumoral heterogeneity;Intervention;Investigation;Journals;Knowledge;Ligands;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;medical schools;Medical Students;member;Mentors;Mesenchymal;Methodology;Molecular;Monitor;multidisciplinary;Mutation;Myelogenous;Neoplasm Metastasis;neoplastic cell;new technology;novel;novel therapeutics;Oncogene Activation;Patients;Peer Review;Pilot Projects;Postdoctoral Fellow;precision oncology;preclinical study;Private Sector;programs;Proliferating;Property;Proteins;Publications;Reagent;receptor;recruit;Regulation;repaired;Research;Research Personnel;Research Training;RNA;Signal Transduction;Solid;stem;stem cell biology;Strategic Planning;symposium;synergism;targeted cancer therapy;targeted treatment;Technology;therapeutic target;therapy resistant;Tissues;Transcriptional Regulation;Translating;Translational Research;treatment response;tumor;tumor microenvironment;tumor progression;tumorigenesis;Work

PROJECT_TITLE: Cancer Biology Research Program


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease

PI_NAMEs: ROBSON, PHILIP MARTYN (contact)

PROJECT_TERMS: Animal Model;Area;Arterial Fatty Streak;Attenuated;Bioinformatics;Biomedical Engineering;biomedical imaging;Biostatistics Core;brain magnetic resonance imaging;Cardiovascular Diseases;Clinical;clinical imaging;Clinical Research;Clinical Trials;Clinical Trials Unit;Data;Data Analyses;data repository;Dedications;Development;Ensure;experience;Extramural Activities;Faculty;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Functional Magnetic Resonance Imaging;Goals;Guidelines;Hematopoietic;Human;Image;Image Analysis;image archival system;imaging modality;imaging study;Imaging technology;Immune;improved;in vivo imaging;Industrialization;Infrastructure;Magnetic Resonance Imaging;Measures;member;Methods;novel;operation;Organ;Positron-Emission Tomography;pre-clinical;preclinical imaging;Program Research Project Grants;programs;protocol development;Protocols documentation;repository;Research;Research Personnel;research study;Role;Secure;Site;Standardization;Statistical Data Interpretation;Stress;Supervision;System;Systems Analysis;Tracer;Update;Validation;vascular inflammation;X-Ray Computed Tomography

PROJECT_TITLE: Imaging Core


PI_NAMEs: TYNER, JEFFREY WALLACE (contact)

PROJECT_TERMS: Address;Advocate;Biological;Biology;cancer type;Catchment Area;CLIA certified;Clinical;clinical investigation;Clinical Trials;clinically relevant;cohort;Collaborations;Combined Modality Therapy;Communities;community engagement;Conduct Clinical Trials;Custom;Data Set;Department of Defense;design;Development;Diagnosis;Direct Costs;Disease;Doctor of Medicine;Doctor of Philosophy;drug development;drug resource;Early Diagnosis;Education;Enrollment;Environment;Faculty;follow-up;Fostering;Foundations;functional genomics;Funding;Future;genomic platform;Goals;Grant;Hematologic Neoplasms;immune checkpoint blockade;improved;improved outcome;Individual;individual patient;innovation;inter-institutional;Intervention;Investigation;Investigational Therapies;Journals;Knowledge;Lead;Leadership;leukemia;Malignant neoplasm of prostate;Malignant Neoplasms;member;Monitor;multiple omics;National Clinical Trials Network;next generation;novel;novel diagnostics;novel drug combination;novel therapeutics;oncology program;Patient-Focused Outcomes;Patients;Peer Review;Pharmaceutical Preparations;Physicians;Positioning Attribute;pre-clinical;precision oncology;Primary Neoplasm;programs;prospective;Publications;Publishing;Research;Research Institute;Research Personnel;Sarcoma;Scientist;Seminal;Shapes;Solid Neoplasm;Southwest Oncology Group;Specimen;standard of care;Strategic Planning;Structure;success;Technology;Therapeutic;therapeutic development;therapy resistant;Time;tool;Training and Education;Translating;translational goal;translational oncology;translational scientist;Translations;treatment trial;tumor;Validation;Work

PROJECT_TITLE: Translational Oncology Research Program


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: Charlestown

ORG_NAME: AMERSA, INC.

PHR: PROJECT NARRATIVE This proposal builds on the considerable strengths of a twenty-year partnership between NIDA and AMERSA to produce an annual addiction science conference that will further open the critical pipeline for a more diverse, equitable, and inclusive community of addiction health professionals and scientists grounded in evidence- based research, practice and policy. AMERSA members represent a wide array of multidisciplinary health professionals, many of whom are national and international leaders in substance use research and education. Given AMERSA’s strong track record in excellent, evidence-based conference training, the potential of this application for strengthening interdisciplinary substance use research, training, practice, and policy is substantial.

PI_NAMEs: FINNELL, DEBORAH S (contact)

PROGRAM_OFFICER_NAME: REICHEL, CARMELA MARIE

PROJECT_TERMS: addiction;Advocacy;Advocate;Affect;Alcohols;Area;ATOD;Award;career development;clinical care;clinical practice;Collaborations;Communities;Continuing Education;Country;cultural competence;Development;Disabled Persons;Discipline;Education;Educational Models;Educational process of instructing;Educational workshop;Environment;Equity;evidence base;Fees;Fostering;Funding;Future;Growth;Health;Health Occupations;Health Policy;Health Professional;high risk population;Home;improved;Individual;innovation;International;Lead;Leadership;Learning;meetings;member;Mentors;Mentorship;Minority Groups;Mission;multidisciplinary;National Institute of Drug Abuse;Nonprofit Organizations;peer coaching;Peer Review;Personal Satisfaction;Persons;Policies;prevent;Professional Education;programs;Public Health;Research;Research Personnel;Science;science teacher;Scientific Advances and Accomplishments;Scientist;Shapes;skills;Substance Addiction;substance use;Substance Use Disorder;symposium;Tobacco;Training;Travel;Underrepresented Populations;Underserved Population;Woman;Work

PROJECT_TITLE: AMERSA Annual National Conference


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

PI_NAMEs: SPELLMAN, PAUL T. (contact)

PROJECT_TERMS: Advanced Development;Area;Atlases;Basic Science;Behavior;Big Data Methods;Biocompatible Materials;Biological Assay;Biophysics;cancer cell;cancer classification;Cancer Detection;cancer genomics;Cancerous;Cells;Chemicals;Chemistry;Clinical;clinical application;Collaborations;Combined Modality Therapy;commercialization;Complex;Computational Biology;Computational Technique;Computer Analysis;Computer Models;Computing Methodologies;Coupled;Data;Data Science;design;Development;Device or Instrument Development;Devices;Diagnosis;Direct Costs;Discipline;Doctor of Philosophy;Dyes;Early Diagnosis;Educational workshop;epigenome;Evaluation;Evolution;Faculty;Foundations;Funding;Galaxy;Genome;Genome Data Analysis Center;Genome Data Analysis Network;genomic data;Genomics;Goals;Grant;Hereditary Nonpolyposis Colorectal Neoplasms;Human;Image;Image Enhancement;imaging capabilities;Imaging technology;improved;improved outcome;Informatics;innovation;instrumentation;inter-institutional;Interdisciplinary Study;Intervention;Investments;Laboratories;Leadership;Malignant Neoplasms;Measurement;medical schools;member;Methodology;Microscope;Molecular;multidisciplinary;National Human Genome Research Institute;new technology;new therapeutic target;next generation;novel;Oncology;oncology program;Outcome;Pacific Northwest;Pathway interactions;Peer Review;Persons;Phenotype;Physicians;Pilot Projects;population based;precision oncology;predicting response;Private Sector;programs;Property;Proteome;Proteomics;Publications;Reagent;recruit;Reporting;Research;Research Personnel;response;Role;Scientist;Screening for cancer;single cell analysis;single cell sequencing;Stains;symposium;System;Systems Biology;Technology;technology development;Testing;Therapeutic Agents;therapy resistant;Tissues;tool;Training and Education;transcriptome;translational applications;tumor;Visualization;Work

PROJECT_TITLE: Quantitative Oncology Research Program


NIH_SPENDING_CATS: Cardiovascular;Data Science;Genetics;Heart Disease;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SHEN, LI  (contact)

PROJECT_TERMS: Address;Animal Model;Bioinformatics;bioinformatics tool;Biometry;Biostatistics Core;Cardiovascular Diseases;Cells;Clinical Research;Code;Communities;Computer software;Data;Data Analyses;data exploration;data harmonization;data mining;data sharing;Dedications;epigenomics;Experimental Designs;experimental study;Image;Immune;Machine Learning;machine learning method;medical schools;Molecular;multiple omics;open source;Patients;phenotypic data;preclinical study;programs;Proteomics;Reproducibility;Research;Research Personnel;Services;Software Tools;Statistical Data Interpretation;Stress;Techniques;Technology;Testing;Tissues;tool;transcriptomics;Visualization

PROJECT_TITLE: Bioinformatics and Biostatistics Core