NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE The proposed research is relevant to public health and timely, because aging populations across the globe are amplifying the burden of tauopathies including Alzheimer’s disease. This study is relevant to the NIH’s mission because it will reveal mechanisms which regulate tau proteostasis and pathobiology in mammalian models, and will thus uncover common mechanistic targets which can be manipulated for treatment development in tauopathies including Alzheimer’s disease. This grant thus addresses the Notice of Special Interest NOT-AG- 21-037: Common Mechanisms and Interactions in Neurodegenerative Diseases.

PI_NAMEs: BURRE, JACQUELINE ;SHARMA, MANU  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Address;Affect;Age;Aging;alpha synuclein;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Area;Binding;Brain;Client;Complex;CRISPR/Cas technology;cysteine string protein;Data;Degradation Pathway;Dementia;Deposition;Equilibrium;experimental study;Gliosis;Goals;Grant;Hsc70 protein;Human;In Vitro;in vivo;Induced Neurons;Injections;innovation;interest;knock-down;Knock-out;Lead;Mass Spectrum Analysis;Measures;Mediator;Mission;Modeling;Modification;Molecular;Molecular Chaperones;Molecular Conformation;monomer;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuron loss;Neurons;novel;overexpression;Pathogenicity;Pathology;Pathway interactions;Patients;Population;prevent;Process;protein TDP-43;Proteins;proteostasis;Public Health;reconstitution;recruit;Research;Risk Factors;Sampling;Synapses;tau aggregation;tau mutation;tau Proteins;Tauopathies;Testing;Therapeutic;therapy development;Transgenic Mice;Translating;ubiquitin-protein ligase;Ubiquitination;United States National Institutes of Health;Viral

PROJECT_TITLE: Tau proteostasis by chaperone-complexes in tauopathies including Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-B (02)]


ADMINISTERING_IC: AT

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Sleep Research;Telehealth

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Insomnia disorder is highly prevalent with a wide range of deleterious health consequences, with bedtime stress and hyper-arousal being a critical cause. While mindfulness meditation mobile apps show promise for improving sleep quality, little or no research has examined bedtime app use which is most prevalent for insomnia. This project is a first step towards examining app-guided bedtime mindfulness for insomnia disorder, assessing timing effects of practice, and using psychological and physiological measures in real-world home settings.

PI_NAMEs: MA, YAN  (contact)

PROGRAM_OFFICER_NAME: CHIDEYA-CHIHOTA, SEKAI RUTENDO

PROJECT_TERMS: acceptability and feasibility;actigraphy;Address;Adherence;Affect;Alcohol abuse;Area;Arousal;Awareness;Beds;behavior test;Behavioral;behavioral sleep intervention;career;Chronic Insomnia;Clinical;Clinical Research;Clinical Trials;Cognitive;Complex;Data;Data Collection;design;Development;disease model;Doctor of Philosophy;Education;Electrocardiogram;Enrollment;expectation;falls;Feasibility Studies;feasibility trial;Feedback;Foundations;Functional disorder;Future;General Population;Goals;Health;Home;Home environment;Hospitals;improvement on sleep;Individual;Informal Social Control;Institution;Instruction;interest;Intervention;intervention delivery;Link;Literature;Maintenance;Measures;Mediating;Medicine;Meditation;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Meta-Analysis;Methods;mHealth;mindfulness;mindfulness intervention;mindfulness meditation;mobile application;mobile computing;Modeling;Narcotics;Nonpharmacologic Therapy;novel;Outcome;Patient Outcomes Assessments;Patients;Pattern;Pharmaceutical Preparations;Phase;Physiological;Pilot Projects;Population;Process;Psyche structure;psychologic;Psychophysiology;Psychosocial Stress;Race;Randomized;Randomized, Controlled Trials;Recommendation;remote assessment;remote delivery;remote technology;Research;Research Methodology;Research Personnel;Resources;response;Severities;Signal Transduction;skills;Sleep;sleep difficulty;Sleep disturbances;sleep health;sleep onset;sleep quality;Sleeplessness;sound;Stress;symposium;System;systematic review;Technology;technology development;Thinking;Time;Training;Translational Research;translational scientist;virtual delivery;wearable device;Work

PROJECT_TITLE: App-guided bedtime mindfulness for insomnia

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (04)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Dementia;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: We cognitive (AD), genes effects enhance exploration assessment ultimately will identify factors related to cognitive resilience, the capacity to maintain preserved function despite presenting a high genetic risk for developing Alzheimer's disease  by developing a novel interpretable artificial intelligence model (iGTP) to unveil the and biological pathways associated with cognitive resilience. Then, we will learn the of multiple biological perturbations and predict their combinations to potentially cognitive resilience. The successful completion of our project will facilitate the  of biological factors related to cognitive resilience to AD, support computational of the combined effect of multiple biological perturbations, and prevent AD development.

PI_NAMEs: DAI, YULIN  (contact);YU, LISHAN ;ZHAO, ZHONGMING

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: Affect;Alzheimer's Disease;artificial intelligence model;Bioinformatics;Biological;Biological Factors;Biological Process;Candidate Disease Gene;candidate validation;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;cognitive enhancement;cognitive function;Communities;Data;data integration;Data Set;deep learning;deep learning model;Development;Dimensions;Disease;drug discovery;Economic Burden;Engineering;enhancing factor;explainable artificial intelligence;generative models;Genes;Genetic;Genetic Risk;Genetic Transcription;Goals;high dimensionality;Impaired cognition;in silico;Individual;insight;Intervention;Investments;Learning;learning progression;machine learning method;Measurement;Modeling;Molecular;Molecular Profiling;multimodality;Nervous System Disorder;Neurofibrillary Tangles;neuropathology;Noise;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Nuclear RNA;Odds Ratio;Ontology;Pathogenesis;Pathologic;Pathway interactions;Persons;Pharmaceutical Preparations;polygenic risk score;preservation;prevent;Prevention;Prevention therapy;Process;programs;promote resilience;Research;research and development;Research Personnel;resilience;resilience biomarker;resilience factor;Resources;Senile Plaques;single nucleus RNA-sequencing;single-cell RNA sequencing;Statistical Models;System;Techniques;therapy development;transcriptome;transcriptome sequencing;Variant;Weight

PROJECT_TITLE: Identify actionable drugs that enhance resilience in Alzheimer's disease individuals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-F (02)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: Los Angeles

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Narrative This project leverages 50 years of data from a longitudinal twin study to explore how alcohol use in midlife relates to risk for Alzheimer’s disease and related dementias (ADRD). We seek to understand differences in these relationships between men and women and in conjunction with the APOE gene, the strongest genetic risk factor for ADRD. Results of this study will contribute to our understanding of the confluence of genetic and environmental factors that increase risk for ADRD and will point to potential mechanisms underlying ADRD risk and protection, which is necessary for designing effective interventions toward reducing the burden of ADRD.

PI_NAMEs: LUCZAK, SUSAN E (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Adult;Affect;Age of Onset;Alcohol consumption;alcohol involvement;alcohol related problem;alcohol risk;alcohol testing;Alcohols;Alleles;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;apolipoprotein E-4;Applications Grants;Attention;Australia;Cholesterol;Clinical;Consumption;Data;Dementia;dementia risk;Denmark;design;Development;Diagnosis;Dizygotic Twins;Dose;effective intervention;Environment;Environmental Risk Factor;Exploratory/Developmental Grant;Female;Finland;Future;Genes;Genetic;genetic risk factor;Genotype;Guidelines;Heavy Drinking;human old age (65+);late life;Life;Life Cycle Stages;Low Prevalence;male;Measures;men;middle age;Modeling;modifiable risk;Monozygotic twins;National Institute on Alcohol Abuse and Alcoholism;Nature;Outcome;Pattern;Phenotype;polygenic risk score;Population;Predictive Value;Recommendation;Registries;Research;research study;Risk;Risk Factors;Sample Size;Sampling;sex;Sex Differences;Testing;Twin Multiple Birth;Twin Studies;Woman;Work

PROJECT_TITLE: Implications of midlife alcohol use for risk of dementia in male and female twins: Unique contributions and interactions with APOE4

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: SARASOTA

ORG_NAME: ROSKAMP INSTITUTE, INC.

ORG_STATE: FL

PHR: Repetitive mild traumatic brain injury (r-mTBI) increases the risk for Alzheimer’s disease related dementia (ADRD), and chronically activated microglia play a principal role in driving tauopathy and cognitive deficits associated with both r-mTBI and ADRD. Our previous work has revealed that activated PTEN signaling may play a role in mediating chronically activated microglia responses and subsequent tau pathology following r-mTBI, therefore in this study we will use a tamoxifen inducible model to validate the role of microglial specific PTEN signaling as a novel target for rescuing chronic microglial activation, tau seeding/pathogenesis, neurodegeneration and cognitive dysfunction post-injury. Our long-term goal is to identify molecular mechanisms causing posttraumatic neuroinflammation that contribute to tau pathology, progressive brain degeneration and associated cognitive impairments, in order to develop new and effective delayed therapeutic interventions to combat neurological complications associated with TBI and ADRD.

PI_NAMEs: OJO, JOSEPH O (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Ablation;Acute;Address;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;Anti-Inflammatory Agents;Appearance;Attenuated;Automobile Driving;Autopsy;Biochemical;Bioenergetics;Brain;Brain Injuries;Cell Survival;cell type;Cells;Chronic;Cognitive deficits;Color;combat;Cre-LoxP;Cytokine Signaling;Elderly;Environmental Risk Factor;Flow Cytometry;functional outcomes;Genes;Genetic;genome wide association study;glial activation;Goals;Human;hyperphosphorylated tau;Impaired cognition;Impairment;improved;In Vitro;Inflammation;Inflammatory;inhibitor;Injury;Intervention;Knock-in;Knock-in Mouse;Lesion;Link;lipid metabolism;Lipids;Long term disability;Mediating;Mediator;Microglia;mild traumatic brain injury;Mining;Modeling;Molecular;mouse model;Mus;Myeloid Cells;Nerve Degeneration;neurobehavior;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;Neurologic;Neurons;neuropathology;neuroprotection;neurorestoration;neurotoxic;novel;novel therapeutics;Outcome;Pathogenesis;Pathologic;Pathology;Patients;Phagocytosis;pharmacologic;Phenotype;Phosphoric Monoester Hydrolases;PIK3CG gene;Play;pre-clinical;Precipitating Factors;preservation;prevent;progressive neurodegeneration;PTEN gene;Reporting;response;response to injury;Role;Sensorimotor functions;Signal Transduction;single-cell RNA sequencing;spatial memory;Specificity;Structure;Synapses;Tamoxifen;tau mutation;tau Proteins;Tauopathies;TBI Patients;TBI treatment;Therapeutic Intervention;Time;Transcript;transcriptomics;Transgenic Model;Traumatic Brain Injury;uptake;Work

PROJECT_TITLE: Aberrant PTEN signaling in chronically activated microglia drives tau pathology, neurodegeneration and cognitive decline following repetitive brain injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: TEANECK

ORG_NAME: PHIBRO ANIMAL HEALTH CORPORATION

ORG_STATE: NJ

PHR: Project Narrative Phibro Animal Health Corporation (PAHC) proposes to prepare an Environmental Assessment (EA) to support the use of Terramycin® 200 for Fish (oxytetracycline dihydrate) Type A medicated article (NADA 038-439) for the control of mortality in penaeid shrimp due to necrotizing hepatopancreatitis associated with Hepatobacter penaei, where PAHC has selected Exponent to assist them in the preparation of the EA. The EA will be prepared following the recommendations in the Phase I Environmental Impact Assessment guidance (Guidance for Industry [GFI] 89) or Phase II Environmental Impact Assessment guidance (GFI 166). The potential environmental issues identified for this drug product, and the approaches used to evaluate whether the identified potential environmental issues are significant will be described.

PI_NAMEs: PARKER, SEAN  (contact)

PROGRAM_OFFICER_NAME: MARESCA, JANAH

PROJECT_TITLE: Environmental Assessment for Oxytetracycline Dihydrate Administered to Shrimp for Minor Use Minor Species

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CVM-J (01)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Annually, almost 8 million1 children are reported to child protective services for potential maltreatment; given the significant individual and societal costs of child maltreatment (CM), it is critical to develop programs to prevent and reduce its recurrence. The proposed project aims to adapt an online educational intervention to equip parents and primary caregivers with a better understanding of what qualifies as CM, strategies to reduce their child’s risk of CM from other adults, and skills to improve parent competency to manage their child’s difficult behavior, to thereby reduce children’s risk of CM. The intervention will adapt existing content and leverage innovative training methodologies from iLookOut, an evidence-based, online training2–4; the proposed intervention will incorporate input from end-users at all stages of development and implementation to ensure feasibility, usefulness, and implementation success.

PI_NAMEs: BARNETT, WHITNEY CHRISTINE (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: 18 year old;abuse neglect;Abuse Reporting;Address;Adult;Behavior;Behavior Therapy;career development;Cessation of life;Child;Child Abuse;Child Abuse and Neglect;Child Behavior;Child Care;child protective service;Child Rearing;community engaged approach;community engagement;Competence;Consultations;Coping Skills;cost;Data;design;Development;Development Plans;Dimensions;Discipline;E-learning;economic cost;Education;Educational Intervention;effective intervention;efficacy outcomes;emotional abuse;Enrollment;Ensure;Evaluation;evidence base;experience;Funding;Future;Goals;Head Start Program;Health;Household;Housing;Impaired cognition;implementation barriers;implementation framework;implementation outcomes;implementation science;improved;Individual;information gathering;Injury;innovation;Intervention;Interview;Journals;K-Series Research Career Programs;Knowledge;Low income;maltreatment;Measures;meetings;Mental disorders;Mentors;Mentorship;Methodology;Methods;Motivation;novel strategies;Nursery Schools;online intervention;Online Systems;Outcome;parenting intervention;Parents;Peer Review;Personal Satisfaction;physical abuse;Poverty;preference;prevent;Prevention;primary caregiver;Problem behavior;Program Development;programs;public health intervention;Publishing;Punishment;Qualifying;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Recurrence;Reporter;Reporting;Research;Research Design;Research Methodology;Research Personnel;Resources;Risk;Risk Factors;Risk Reduction;satisfaction;School-Age Population;Sexual abuse;skills;societal costs;Stress;success;Testing;theories;therapy design;therapy development;Time;Training;Trauma;United States Dept. of Health and Human Services;user centered design;Violence;web-based intervention

PROJECT_TITLE: Adapting a web-based parent training to reduce child maltreatment

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Nutrition;Obesity;Pediatric;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Food insecurity in pregnancy predicts excess gestational weight gain and postpartum weight retention, is associated with intergenerational obesity risk, and disproportionately affects pregnant individuals with minoritized identities. To develop interventions that target obesity risk in pregnant and postpartum individuals with food insecurity, it is first necessary to identify the behavioral and psychosocial pathways through which food insecurity contributes to weight change during these periods. Through a community-engaged research lens that prioritizes ongoing collaboration with community members, this study will test momentary and longitudinal relationships among food insecurity, appetitive drives, psychosocial distress, disinhibited eating, and weight change in pregnancy and postpartum, thus informing treatment targets for future multi-level intervention development work and promoting intergenerational health equity.

PI_NAMEs: CALL, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Address;Affect;Anxiety;Behavioral;Body Weight Changes;career;Clinical;Communities;community collaboration;community engaged research;community partners;Data;delivery complications;Desire for food;Dimensions;Discrimination;Disinhibition;Distress;early pregnancy;Eating;Eating Behavior;Ecological momentary assessment;Educational Status;Enrollment;Equity;ethnic identity;ethnic minority;excessive weight gain;experience;Food;Food Access;food insecurity;Future;gestational weight gain;Goals;Health;health equity;health equity promotion;Health equity research;high risk;improved;Individual;Infant Health;innovation;intergenerational;Intervention;Late pregnancy;lens;Life;Life Cycle Stages;Link;Literature;Mediating;Mediator;member;Mentors;Methods;Minority;Mission;Modeling;Moods;National Institute of Diabetes and Digestive and Kidney Diseases;Obesity;obesity risk;offspring;Outcome;outcome prediction;Participant;Pathway interactions;perceived discrimination;Perinatal;perinatal health;perinatal period;Persons;Population;Populations at Risk;Postpartum Period;postpartum weight;Pregnancy;Pregnancy Complications;Pregnancy Trimesters;pregnant;prevent;Prevention;Process;programs;prospective;psychologic;Psychologist;psychosocial;Psychosocial Assessment and Care;racial minority;Reporting;Research;Research Design;Risk;Sampling;skills;social;social health determinants;Testing;theories;therapy development;Time;Training;Weight;Well in self;Work

PROJECT_TITLE: Longitudinal and Momentary Associations Underlying the Relation of Food Insecurity and Gestational Weight Gain: Toward Obesity Risk Prevention

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Atherosclerosis;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: WINSTON-SALEM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Vascular disorders are well-known risk factors of late-life dementia; yet, the ways that vascular disorders contribute to dementia are unclear. We propose that early “subclinical” changes in structure, function, and molecules of the blood vessels will show the pathways by which vascular disorders may influence blood proteins levels related to Alzheimer’s disease and changes in brain structure and function underlying our risk for dementia.

PI_NAMEs: HUGHES, TIMOTHY M. (contact);LIU, YONGMEI ;LUCHSINGER, JOSE ALEJANDRO

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Acceleration;Address;adjudication;Adult;aged;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Arteriosclerosis;Atherosclerosis;Atrophic;Biological Markers;Black race;Blood Pressure;Blood Proteins;Blood Vessels;Brain;Brain imaging;brain magnetic resonance imaging;Cardiovascular system;Cerebral small vessel disease;Chinese American;clinical development;clinical phenotype;Cognition;Cognition Disorders;Cognitive;cognitive testing;cohort;Collection;comorbidity;Data;data resource;deep learning;Dementia;dementia risk;design;Development;Diabetes Mellitus;Disease;ethnic difference;ethnic disparity;Ethnic Population;Etiology;follow-up;Funding;Gender;gender difference;Genome;Genomics;Glial Fibrillary Acidic Protein;Goals;Growth;health disparity;heart function;Hemorrhage;Hispanic;human old age (65+);Hypertension;Image;imaging biomarker;Impaired cognition;Impairment;Individual;Infrastructure;Kidney Diseases;late life;Light;Magnetic Resonance Imaging;Measures;men;Metabolic;metabolome;metabolomics;Molecular;Molecular Profiling;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;multidisciplinary;Multilingualism;multimodality;Nerve Degeneration;neurofilament;neuroimaging;neuroinflammation;older adult;Participant;Pathway interactions;Patient Self-Report;Peripheral;PET positivity;Phenotype;Plasma;Population;Positioning Attribute;Positron-Emission Tomography;predictive marker;predictive modeling;progression marker;Proteome;Proteomics;Publications;racial difference;racial disparity;racial population;Recommendation;recruit;Research;research study;Resources;Risk Factors;Site;social health determinants;Structure;Subgroup;symposium;tau-1;Technology;Time;Trans-Omics for Precision Medicine;United States National Institutes of Health;vascular cognitive impairment and dementia;vascular contributions;Vascular Diseases;Visit;White Matter Hyperintensity

PROJECT_TITLE: Subclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative In the face of extensive clinical and pathologic heterogeneity in FTLD, biomarkers are critical to the success of FTLD clinical trials. Findings from this proposal will provide the field of FTLD with pathologically-validated biofluid biomarkers, which track with FTLD pathological cascades. Our clinical translational aim is to develop multi- analyte biofluid algorithms for much-needed screening and prognosis in FTLD.

PI_NAMEs: COUSINS, KATHERYN ALEXANDRA QUILICO (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Adult;Age;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Autopsy;Biological;Biological Markers;Biology;biomarker validation;Cells;Cerebrospinal Fluid;Chitinase;Classification;Clinical;clinical application;Clinical Data;clinical translation;Clinical Trials;Cognitive;cohort;Cross-Sectional Studies;Data;Data Set;Diagnosis;Diagnostic;diagnostic tool;Differential Diagnosis;digital;Disease;Disease Marker;Disease Progression;end stage disease;Enrollment;Ensure;experimental study;Family;Frontotemporal Lobar Degenerations;Functional disorder;Genetic;Glial Fibrillary Acidic Protein;Gliosis;Goals;Heterogeneity;Histopathology;Immunoassay;improved;in vivo;Individual;Inflammation;Inflammatory;inflammatory marker;Investigation;Life;Light;longitudinal analysis;Machine Learning;Magnetic Resonance Imaging;Maps;Measures;Modeling;Molecular;Motor;multimodality;Mutation;Natural History;Nerve Degeneration;neurofilament;neurogranin;neuroimaging;neuroinflammation;neuronal pentraxin;neuropathology;next generation;novel diagnostics;novel strategies;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pennsylvania;Phase;Plasma;pre-clinical;Process;Prognosis;prognostic;prognostic tool;protein TDP-43;Proteins;radiological imaging;Research;Sampling;screening;Severity of illness;Site;specific biomarkers;Stereotyping;success;symposium;Symptoms;Synapses;Syndrome;System;tau Proteins;Tauopathies;Testing;therapeutic development;tool;translational goal;Universities;Validation

PROJECT_TITLE: Pathology-guided biofluid biomarker strategies for classification and progression of frontotemporal lobar degeneration (FTLD)


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Dissemination and Implementation Research;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Serious Mental Illness

PHR: 8. Project Narrative This project addresses the extreme burden of unmet mental health needs in India by continuing our two decades of success in building research capacity. The current proposal expands our work by amplifying leadership in India; providing interdisciplinary, team-based training to early-career researchers and senior-career mentors on medical, neurodevelopmental, and neurodegenerative disorders; and deepening our partnership with the Indian Council of Medical Research (ICMR). Through this work we will continue our demonstrated success in training individuals, nurturing interdisciplinary research teams, supporting scholarly output via peer-reviewed publications and presentations, and building on these outcomes to leverage additional research funds for Indian researchers, while continuing dialogue with ICMR regarding capacity building and policy.

PI_NAMEs: DESHPANDE, SMITA N;HAWK, MARY ELIZABETH;NIMGAONKAR, VISHWAJIT LAXMIKANT (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Address;Advocate;autism spectrum disorder;burden of illness;career;Collaborations;comorbidity;Country;Dementia;Diabetes Mellitus;Disease;Epidemic;Faculty;Fogarty International Center;Fostering;Government;Grant;Hospitals;Hyperglycemia;implementation research;implementation science;India;Institution;interdisciplinary approach;interest;Intervention;Intervention Studies;Leadership;life span;low and middle-income countries;Medical;Medical Research;medical schools;Mental disorders;Mental Health;Mentors;Modeling;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurologic;next generation;novel;Peer Review;Psychiatrist;Psychoses;Publications;Publishing;Research;Research Domain Criteria;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;scale up;severe mental illness;social stigma;Strategic Planning;Substance Use Disorder;success;Training;Training and Infrastructure;Update;Work

PROJECT_TITLE: Psychiatric research infrastructure for intervention and implementation in India – TEAMS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-C (50)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Genetics;Machine Learning and Artificial Intelligence;Mental Health;Nutrition;Obesity;Prevention

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE This proposal aims to determine how psychological or biological factors predict outcomes of people with obesity following lifestyle interventions. The results from this study will provide evidence as to how stress, resilience, and epigenetic data can predict the efficacy of lifestyle interventions at reducing weight and preventing the development of insulin resistance and type II diabetes. By improving our understanding of what treatments will succeed for a given patient, this proposal will accelerate the development of precise, individualized treatment for people with obesity, allowing individuals to more quickly obtain the treatment that will work best for them.

PI_NAMEs: HARVANEK, ZACHARY MATHIAS (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Acceleration;Address;adult obesity;Affect;age acceleration;American;Attention;Behavioral;Biological;Biological Factors;Biological Markers;Blood;Blood specimen;Body mass index;Body Weight decreased;Cardiac health;Cardiovascular system;Classification;Clinical;clinical practice;clinical training;Clinical Trials;comorbidity;Computing Methodologies;Counseling;COVID-19;Cross-Sectional Studies;Data;Death Rate;Development;Diabetes Mellitus;Educational workshop;Environmental Risk Factor;Epidemic;epigenetic clock;epigenetic marker;Epigenetic Process;epigenome;Exercise;Failure;Feeding behaviors;Fellowship;follow-up;Foundations;Functional disorder;Funding;glycemic control;improved;improved outcome;Individual;individualized medicine;Inflammation;Institution;Insulin Resistance;Intake;Intervention;Life Style;lifestyle intervention;Link;Machine Learning;Maintenance;Measures;Mediating;Medical;meetings;men;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Metabolic;Metabolic Diseases;Metabolic dysfunction;Methylation;methylation pattern;Modeling;Modification;Morbidity - disease rate;multimodality;Neurobiology;Non-Insulin-Dependent Diabetes Mellitus;Nonpharmacologic Therapy;nutrition;Nutritional;obese patients;Obesity;Obesity associated disease;obesity risk;obesity treatment;Operative Surgical Procedures;Outcome;outcome prediction;Parents;Participant;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;physical conditioning;Population;Positioning Attribute;post intervention;Prediction of Response to Therapy;predictive modeling;prevent;primary outcome;prospective;Psychiatric therapeutic procedure;psychologic;Psychological Factors;Psychological Stress;Public Health;Publishing;Research;Research Personnel;Research Training;resilience;resilience factor;Resources;response;Risk;Risk Factors;SARS-CoV-2 infection;Self-control as a personality trait;Site;Societies;Speed;Stimulus;Stress;stress reduction;success;supervised learning;Techniques;Testing;Time;Training;treatment guidelines;Treatment outcome;TXNIP gene;United States;Woman;Work

PROJECT_TITLE: Psychological and Epigenetic Predictors of Obesity & Metabolic Disease


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Epilepsy;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE Impaired consciousness in epilepsy has a significant impact on patient safety, productivity, physical and psychological health. We will investigate ictal and interictal network dysfunction and their association, and develop a clinical tool to predict impaired consciousness during seizures from EEG without the need for behavioral testing. This study will provide an improved understanding of brain network abnormalities in epilepsy and will provide approaches that can significantly improve patient quality of life by facilitating accurate diagnosis, decisions about medication adjustment, and presurgical evaluation as well as allowing clinicians to precisely evaluate the ability of patients to complete daily-life activities such as driving.

PI_NAMEs: KHALAF, AYA  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Absence Epilepsy;accurate diagnosis;Address;Affect;Automobile Driving;Behavior;Behavior assessment;behavior prediction;behavior test;Behavioral;behavioral impairment;Brain;brain dysfunction;Characteristics;Chronic;Clinical;Code;Cognitive deficits;comparative;Conscious;Data;Data Set;deep learning;Development;driving safety;effective intervention;effective therapy;Electroencephalography;Epilepsy;Evaluation;Evolution;experimental study;Frequencies;Functional disorder;Hospitals;Impact Seizures;Impairment;improved;innovation;Inpatients;insight;large datasets;Life;lifestyle factors;Machine Learning;Mental Health;Modeling;Morbidity - disease rate;mortality;Nervous System Disorder;network dysfunction;neural;Neuropsychology;neuroregulation;novel marker;Operative Surgical Procedures;patient safety;Patient-Focused Outcomes;Patients;Pattern;Persons;Pharmaceutical Preparations;physical conditioning;Physiological;Positioning Attribute;predictive modeling;Productivity;Quality of life;Recurrence;Scalp structure;Seizures;Site;spatiotemporal;statistics;targeted treatment;Techniques;Testing;Time;tool;transfer learning;United States;Work

PROJECT_TITLE: Network dysfunction and impaired consciousness in epilepsy

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Dementia involves changes in brain lipids, but the exact cell type-specific effects and mechanisms are not clear. Astrocytes are essential for brain lipid metabolism and neuronal function, and may be impaired in dementia. The proposed study will investigate how dementia-related factors and pathways influence astrocyte lipids and lipid- based regulation of neuronal function.

PI_NAMEs: MCINTIRE, LAURA BETH JOHNSON;ORR, ANNA GOLDSHMIDT (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: abeta accumulation;abeta oligomer;Address;Affect;Age;age effect;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;amyloid precursor protein processing;Apolipoprotein E;Astrocytes;Behavioral;Binding Proteins;Brain;Brain region;cell type;Cells;Cholesterol;Cognition Disorders;Complex;cytokine;Cytokine Signaling;Data;Dementia;Dependence;Disease;disorder risk;Enzymes;Evaluation;Exposure to;fatty acid biosynthesis;Fatty Acids;Genes;Genetic;genetic risk factor;Genetic Transcription;Health;Homeostasis;Human;human induced pluripotent stem cells;Impaired cognition;Impairment;in vivo;Inflammatory;inhibitor;innovation;insight;Investigation;Knock-in;Knock-in Mouse;Late Onset Alzheimer Disease;Link;lipid metabolism;lipidome;lipidomics;Lipids;Lipoproteins;Measures;Membrane;Membrane Microdomains;Methods;Molecular;Molecular Profiling;mouse model;Mus;neural;Neurites;Neurodegenerative Disorders;Neuroglia;Neuroimmune;neuroinflammation;Neurons;neuropathology;Neurophysiology - biologic function;neurotoxic;new therapeutic target;Nonesterified Fatty Acids;novel;novel strategies;novel therapeutic intervention;Pathogenesis;Pathologic;Pathology;Pathway interactions;Plasma;Preparation;Process;Production;Prosencephalon;reconstitution;Regulation;Regulatory Element;Resources;Risk;RNA;RNA analysis;Same-sex;Signal Induction;Signal Transduction;spatiotemporal;Sphingolipids;Sterols;Synapses;synaptogenesis;tau Proteins;Testing;Therapeutic;therapeutic biomarker;Transcript;Transgenic Organisms;Translating

PROJECT_TITLE: Uncovering Dementia-Related Lipid Alterations and Mechanisms in Astrocytes

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative Despite the observed epidemiological evidence, the detailed molecular mechanisms explaining how air pollution exposures (both individually and as a mixture) affect Alzheimer’s Disease and related dementias (AD/ADRD) are still largely unknown. We will investigate the molecular connections underlying the neurotoxicity of air pollution using innovative cross-tissue approaches, with the overarching goal of providing key insights into the relationship between air pollution mixtures, biological response profiles, and AD/ADRD, supporting future efforts that aim to inform environmental regulation and health policy to mitigate air pollution- related risk for AD/ADRD.

PI_NAMEs: HUELS, ANKE  (contact);LIANG, DONGHAI

PROJECT_TERMS: Address;Affect;African American;Age;Air Pollutants;Air Pollution;Alzheimer's disease related dementia;Alzheimer's disease risk;ambient air pollution;Ammonium;Amyloid beta-42;Automobile Driving;Autopsy;Biological;Biological Markers;Blood;Blood specimen;Brain;brain dysfunction;burden of illness;Carbon;Carbon Monoxide;Cerebrospinal Fluid;Chronic Disease;Clinical;Cognitive;cognitive function;cohort;Data;dementia risk;Development;Disease;disorder prevention;Early identification;Elements;Enrollment;Environmental Health;Epidemiology;Etiology;Exposure to;fine particles;Functional disorder;Future;global health;Goals;Health;Health Policy;Impaired cognition;Individual;Inflammation;innovation;insight;Link;Literature;Maps;Metabolic dysfunction;metabolome;metabolomics;Metals;Modeling;modifiable risk;Molecular;Nervous System;Neurofibrillary Tangles;neuropathology;neurotoxic;neurotoxicity;Nitrates;Nitrogen Dioxide;novel;novel strategies;Oxidative Stress;Ozone;Participant;Pathway interactions;Play;potential biomarker;prospective;racial diversity;Regulation;Research;Resolution;response;Risk;Risk Factors;Role;Sample Size;Sampling;Senile Plaques;small molecule;spatiotemporal;Sulfate;tau Proteins;tau-1;Technology;Tissues;Visit

PROJECT_TITLE: Air pollution, the blood and brain metabolome and their effects on Alzheimer's disease and related dementias


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE Alzheimer's special care units (SCUs) in nursing homes are a major innovation in dementia care, yet the majority of nursing homes do not have SCUs, especially those serving a high proportion of Black and Hispanic residents. By analyzing national resident and facility data and unique Ohio surveys, this study will examine SCU access as a pathway of racial and ethnic disparities in dementia-related outcomes, and will identify the state policies and regulations associated with increased SCU availability. Because federal and state governments are currently implementing reforms to improve nursing home care, our analyses will improve the understanding of SCU factors which can inform a policy approach to improve quality and reduce disparities in nursing homes.

PI_NAMEs: XU, HUIWEN  (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: access disparities;Address;Admission activity;adverse outcome;Affect;Aggressive behavior;Alzheimer's Disease;Alzheimer's disease related dementia;Antipsychotic Agents;Behavior;Black race;Black, Indigenous, People of Color;care outcomes;Caring;Certification;Characteristics;Cognitive;cost;County;COVID-19 pandemic;Data;Data Set;decubitus ulcer;Dementia;dementia care;Development;Disincentive;Disparity;disparity reduction;Drops;Environment;ethnic difference;ethnic disparity;ethnic health disparity;ethnic minority;experience;Family;Federal Government;Growth;Health;health care disparity;health disparity;Healthcare;Hispanic;Home Nursing Care;Hospitalization;hospitalization rates;Impaired cognition;improved;improved outcome;Incentives;innovation;Long-Term Care;Mediation;Medicaid;Medicare claim;Methods;Minority;Modeling;National Institute on Aging;Nursing Homes;Nursing Models;Ohio;older adult;Outcome;Pathway interactions;payment;Pharmaceutical Preparations;Physical environment;Physical Function;Physicians;Policies;Policy Maker;prevent;Probability;Problem behavior;Provider;Quality of Care;Quality of life;racial difference;racial disparity;racial minority;Racial Segregation;Regulation;Reporting;restraint;Role;satisfaction;State Government;Surveys;Training

PROJECT_TITLE: Alzheimer's Special Care Units in Nursing Homes: Racial and Ethnic Disparities, Resident Outcomes, and State Policies

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Lung;Neurosciences;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: POMONA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: WESTERN UNIVERSITY OF HEALTH SCIENCES

PHR: Project Narrative: Tuberculous Meningitis (TBM) is the most severe form of extrapulmonary tuberculosis in humans worldwide. Delay in the treatment or sub-optimal treatment of TBM cases results in either death or substantial neurological morbidity. Studies proposed in this application will unfold the pivotal mechanisms involved in protection against TBM and will specify whether glutathione can be used as a promising adjunctive immunotherapeutic agent to prevent the development of TBM.

PI_NAMEs: VENKETARAMAN, VISHWANATH  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;Adopted;Antibiotic Therapy;Antimycobacterial Agents;Antitubercular Agents;Applications Grants;Arachnoiditis;Area;Award;Bacillus;Bacteriology;Biochemical;Cause of Death;Cells;Central Nervous System;Central Nervous System Tuberculosis;Cessation of life;Childhood;Clinical;combat;cytokine;Defense Mechanisms;Development;Diagnosis;Drug usage;Early Diagnosis;effective therapy;Equilibrium;extensive drug resistance;Female;Foundations;Functional impairment;Glutathione;Goals;Growth;Hematogenous;HIV Infections;HIV/AIDS;Homeostasis;Human;Immune;immune function;immune modulating agents;Immune response;Immunocompromised Host;Immunologics;Immunotherapeutic agent;Immunotherapy;improved;in vitro activity;in vivo;Incidence;Individual;Interleukin-12;Interleukin-2;Intracranial Tuberculoma;isoniazid;Low income;Lung;Macrophage;male;Medical emergency;Meningeal Tuberculosis;monocyte;Morbidity - disease rate;mortality;Mus;Mycobacterium Infections;Mycobacterium tuberculosis;Natural Killer Cells;Neurologic;novel;novel therapeutics;Outcome;Oxidation-Reduction;Pathogenesis;Pathologic;Persons;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Predisposition;prevent;protective effect;Pulmonary Tuberculosis;Refractory;Regimen;Reporting;Research;resistant strain;response;restoration;Rifampin;Risk;Specific qualifier value;Spinal;Spleen;Sulfhydryl Compounds;T-Lymphocyte;Testing;Therapeutic Agents;Tuberculosis;tuberculosis drugs

PROJECT_TITLE: Glutathione depletion in the CNS and its effects on Mtb infection

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Boulder

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Alzheimer's disease and type 2 diabetes mellitus are two of the most prevalent diseases in the elderly population. This project aims to understand at the molecular level why diabetic patients are at a higher risk of developing dementia by studying the relationship between hyperglycemia and protein aggregation.

PI_NAMEs: WALCZAK, MACIEJ  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: accurate diagnostics;Acetylation;Advanced Glycosylation End Products;Affect;Aldehydes;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease risk;Amino Acids;antagonist;Behavior;Biochemical;Biology;Biophysics;Carbohydrates;Cell Culture Techniques;Cells;Characteristics;Chemicals;Chemistry;Clinical;Clinical Research;Collaborations;covalent bond;crosslink;Cryoelectron Microscopy;cytokine;cytotoxicity;Data;Dementia;Development;diabetic patient;diagnostic tool;Disease;Disease Marker;Disease Progression;Elderly;epidemiology study;Glucose;glucose metabolism;glycation;graduate student;high risk;Human;human induced pluripotent stem cells;Hyperglycemia;Hyperinsulinism;hyperphosphorylated tau;In Vitro;Individual;Induced pluripotent stem cell derived human neuron;Inflammation;Inflammatory;insight;Institution;Interneurons;K-18 conjugate;ketoaldehyde;Link;Literature;Lysine;Mentors;Methylation;Microglia;mitochondrial dysfunction;Modeling;Modification;Molecular;Molecular Biology;Monitor;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;neuron loss;Neurons;neurotoxicity;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Norepinephrine;novel therapeutic intervention;Oxidative Stress;paired helical filament;Pathogenesis;Pathologic;Pathway interactions;Phase;Phosphorylation;Physiology;Population;Post-Translational Protein Processing;Process;Production;protein aggregation;Proteins;receptor for advanced glycation endproducts;Research;Resolution;response;Ribose;Role;Site;Solvents;structural biology;Structure;sugar;synergism;tau aggregation;tau function;tau Proteins;Testing;Therapeutic;tool;Toxic effect;transmission process;uptake;Variant

PROJECT_TITLE: Non-enzymatic post-translational modifications as drivers of AD pathology

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Coronaviruses;Dementia;Emerging Infectious Diseases;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: PROJECT NARRATIVE COVID-19 is associated with numerous vascular complications causing significant morbidity and mortality and I hypothesize that cerebral microvascular inflammation and dysfunction plays a critical role in neurologic post- acute sequelae of SARS-CoV-2 infection (PASC). I have studied individuals with neuro-PASC compared to healthy controls and identified differences in perfusion on MRI, six cardiovascular biomarkers, and deficits in several cognitive domains. In this study, I will utilize advanced vascular MRI techniques to investigate for biomarkers of cerebral microvascular dysfunction in the brain to better understand the pathophysiology of neuro-PASC cognitive symptoms.

PI_NAMEs: MCALPINE, LINDSAY  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: acute COVID-19;Adult;Atrophic;Autopsy;Award;Biological Markers;Biology;biomarker identification;Blood;Blood Coagulation Disorders;Blood Platelets;Blood Tests;Blood Vessels;Brain;Cardiovascular system;Case Series;Case/Control Studies;cerebral hypoperfusion;Cerebrum;Clinic;Clinical;Cognition;Cognitive;Cognitive deficits;common symptom;comparison control;COVID-19;Data;Diffusion;Disease;Dizziness;endothelial dysfunction;Endothelium;Enrollment;Exhibits;Fellowship;Functional disorder;Future;Goals;Headache;Health;Heart;high risk;hypoperfusion;Image;Impaired cognition;inattention;Individual;Inflammatory;insight;instructor;Ischemic Stroke;Laboratories;Language;Link;Long-Term Effects;Longitudinal Studies;Lung;Lymph Node Mapping;lymphatic vasculature;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Memory;Mental Health;Mentors;Mentorship;Microvascular Dysfunction;Mind;Moods;Morbidity - disease rate;mortality;Motor;Nerve Degeneration;Neurobehavioral Manifestations;neuroimaging;Neurologic Effect;neurologic sequelae of COVID-19;Neurologist;Neurology;neuropsychiatry;Neuropsychological Tests;Neuropsychology;Participant;Pathology;Patient Care;Patient Recruitments;Patients;Perception;Perfusion;Persons;Physicians;Pilot Projects;Play;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID-19;primary outcome;Probability;Process;progression risk;Protocols documentation;Public Health;Publishing;recruit;Reporting;research study;Residual state;Risk;Role;SARS-CoV-2 infection;Scientist;Severities;Short-Term Memory;Sleeplessness;statistics;Symptoms;Techniques;Testing;Time;Training;Vascular Dementia;Vascular Diseases;vascular inflammation;Venous;Visit

PROJECT_TITLE: Magnetic Resonance Imaging Biomarkers of Post-COVID-19 Cerebral Microvascular Dysfunction

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: WALTHAM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project narrative The proposed research will elucidate basic mechanisms of transcription regulation, which in the long term will improve public health by improving our understanding of human biology. In addition, the proposed research will help define the molecular bases for regulatory mechanisms that affect virulence and environmental dissemination of human pathogens. This basic knowledge is expected to aid in scientific research aimed at development of agents to combat infectious disease.

PI_NAMEs: GELLES, JEFF  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Affect;Bacteria;Bacterial RNA;base;Binding;Biochemical;Biophysical Process;brain cell;Cell Differentiation process;Cell Physiology;Cells;Chemicals;ChIP-seq;Code;combat;combinatorial;Communicable Diseases;Complex;Cryoelectron Microscopy;Data;Development;Disease;DNA;DNA-Directed RNA Polymerase;Elongation Factor;Enzymes;Escherichia coli;Eukaryota;Fluorescence;Gene Expression;Gene Expression Regulation;Genes;genetic regulatory protein;Genetic Transcription;Goals;Human Biology;human pathogen;improved;In Vitro;Individual;insight;Kinetics;Knowledge;Length;Macromolecular Complexes;Malignant Neoplasms;Messenger RNA;Methods;Modeling;Molecular;molecular dynamics;Molecular Structure;Normal Cell;operation;Organism;Outcome;Pathway interactions;Pattern;Polymerase;Production;programs;Property;Proteins;Public Health;Reaction;recruit;Regulation;Repression;Research;RNA;RNA chemical synthesis;RNA Polymerase II;Saccharomyces cerevisiae;Saccharomycetales;single molecule;Small RNA;Speed;Stimulus;study population;System;Testing;Time;Transcript;transcription factor;Transcriptional Regulation;Virulence;Visualization

PROJECT_TITLE: Single-molecule visualization of transcription regulation mechanisms

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: ORLANDO

ORG_NAME: ADVENTHEALTH ORLANDO

PHR: NARRATIVE In the present proposal we propose to analyze cortisol on banked hair samples collected as part of the Phase III multi-site IGNITE (Investigating Gains in Neurocognition in an Intervention Trial of Exercise) project. Our aim is to examine whether a 12-month aerobic exercise intervention induces changes in hair cortisol concentration and whether these changes statistically mediate intervention-related changes to cognitive performance, brain volume and function, and Alzheimer’s disease neuropathology.

PI_NAMEs: OBERLIN, LAUREN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: actigraphy;Address;Adherence;Adopted;Adult;Aerobic Exercise;Affect;Age Years;Age-associated memory impairment;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-42;Amyloid beta-Protein;arterial stiffness;Binding;Biological;Biological Assay;Biological Markers;blind;Blood;Blood Banks;Body Composition;Brain;brain health;brain morphology;Brain region;brain volume;cardiorespiratory fitness;Cerebrovascular Circulation;Cognition;Cognitive;cognitive change;cognitive function;cognitive performance;cohort;cost;cytokine;Data;data sharing;Databases;Dementia;dementia risk;design;Dose;executive function;Exercise;exercise intervention;expectation;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Future;Glucocorticoids;Hair;Health;high reward;high risk;Hippocampus;Hormones;Human;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Impaired cognition;improved;Inflammatory;interest;Intervention;Intervention Trial;Lesion;light intensity;Magnetic Resonance Imaging;Measures;Mediating;Memory;Methods;Mission;Modification;Moods;Neurocognition;Neurocognitive;Neuronal Plasticity;neuropathology;neurotrophic factor;novel;older adult;Outcome;Parents;Participant;Pathway interactions;perceived stress;Peripheral;Personality;Phase;Phenotype;Physical activity;Physical Function;Physiological;Positron-Emission Tomography;Prefrontal Cortex;prevent;primary endpoint;programs;Public Health;randomized, clinical trials;Recommendation;Research Personnel;response;Rest;Rodent;Sample Size;Sampling;secondary endpoint;Site;Sleep;Social Network;Socioeconomic Status;Stress;Structure;Testing;Underrepresented Minority;United States National Institutes of Health;white matter;β-amyloid burden

PROJECT_TITLE: Exercise, Stress Biomarkers, and Alzheimer's Disease Neuropathology

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: The proposed research will result in technologies that enable the easy nanoscale imaging of lipid membranes, organelles, and proteins, in Alzheimer’s disease, with resolution and context sufficient to enable discovery of novel mechanisms of Alzheimer’s disease, which in the future may yield new therapeutic targets.

PI_NAMEs: BOYDEN, EDWARD S. (contact);TSAI, LI-HUEI

PROJECT_TERMS: Affect;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;amyloid precursor protein processing;analytical tool;Animal Model;Antibodies;Apolipoprotein E;apolipoprotein E-4;Architecture;Astrocytes;Atlases;Autopsy;Biological;Biology;brain cell;brain circuitry;Brain Pathology;brain tissue;Cell membrane;cell type;Cessation of life;Characteristics;Chemicals;Cholesterol;Code;Data;Democracy;Deposition;Development;Disease;Electron Microscopy;Endoplasmic Reticulum;endoplasmic reticulum stress;Endosomes;Equipment;Etiology;extracellular;Future;Genes;genetic risk factor;Golgi Apparatus;Grant;Head;Human;human tissue;hyperphosphorylated tau;Image;Impaired cognition;Impairment;Inflammation;invention;late endosome;Late Onset Alzheimer Disease;lipid transport;Lipids;Lysosomes;Mediating;Membrane;Membrane Lipids;Membrane Microdomains;Methods;Microglia;Microscope;Microscopy;Mitochondria;Modeling;Molecular;Morphology;mouse model;Mus;Myelin;myelination;nanoscale;Neurodegenerative Disorders;Neuroglia;neuron loss;Neurons;new therapeutic target;Noise;novel;Oligodendroglia;optogenetics;Organelles;Pathology;Play;preservation;Procedures;Production;Property;Proteins;Protocols documentation;Publications;Reporting;Research;Research Personnel;Resolution;Resource Sharing;risk variant;Role;Science;Senile Plaques;Signal Transduction;Site;skills;Specimen;Stains;Subcellular structure;success;Synapses;tau aggregation;Technology;Temperature;Tissues;tool;Validation;Visualization

PROJECT_TITLE: Lipid imaging expansion microscopy to study Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: TAMPA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: PROJECT NARRITIVE More than one-third of the one million older adults living in assisted living (AL) communities in the United States have a diagnosis of Alzheimer’s disease or related dementia (ADRD) with an estimated 40% spending their remaining years of life in AL, making it a common site for end-of-life care and the AL nursing workforce. comprising close to 300,000 full-time employees, is challenged to meet end-of-life ADRD care needs. The proposed project will conduct an NIH Stage 3 cluster randomized trial of a palliative care education in assisted living for dementia care providers (PCEAL-DCP) intervention to improve end-of-life care through facilitation by hospice nurses and social workers training staff in how to have advance care planning discussions with family members of residents with dementia and appropriately refer residents to hospice with secondary aims to test staff self-efficacy as a potential mechanism for improving not only resident care but staff satisfaction and commitment. The intervention has the potential for wide dissemination and could be vital in addressing the numerous workforce challenges in providing high-quality palliative and end-of-life care commonly found in AL communities, including lack of staff training in communication with family members, advance care planning, and staff self-efficacy to provide palliative care.

PI_NAMEs: DOBBS, DEBRA JEAN (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Address;Administrator;Admission activity;Advance Care Planning;advanced directive;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;arm;Assisted Living Facilities;behavior change;care outcomes;care preference;care providers;Caring;Clinical Trials;Cluster randomized trial;Communication;community living;comparison control;Competence;Continuing Education;Control Groups;Data;decision-making capacity;Dementia;dementia care;Discipline of Nursing;Documentation;Education;Educational Intervention;effectiveness evaluation;efficacy evaluation;Employee;end of life;end of life care;end of life outcomes;Enrollment;Family;Family member;feasibility testing;Florida;Funding Opportunities;group intervention;Healthcare;hospice environment;hospice utilization;Hour;improved;Individual;Intervention;Job Satisfaction;Knowledge;Length;Life;Manuals;Modeling;Nurses;Occupations;older adult;Outcome;palliative;Palliative Care;Palliative Care Nursing;Performance at work;Persons;Pilot Projects;post intervention;preference;primary outcome;Process;programs;Protocols documentation;provider intervention;Publishing;Quality of Care;Randomized;Research;Sampling;satisfaction;secondary outcome;Self Efficacy;Site;Social Workers;Structure;Testing;Training;treatment as usual;treatment comparison;treatment site;United States;United States National Institutes of Health

PROJECT_TITLE: Preparing Assisted Living Staff to Care for Persons with Dementia: Palliative Care Education in Assisted Living for Dementia Care Providers

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Lymphatic Research;Neurosciences

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Lymphatic dysfunction is closely related to major human diseases, including lymphedema, glaucoma, immune dysfunction, cancer, metabolic disease, and neurodegenerative disease. This project will decipher regulation of lymphatic endothelial cell junction and drainage, focusing on ROCK1/2 and integrin α5 signals by using a bioengineered 3D lymphatic vascular system in vitro and mouse inflammation and lymphedema models in vivo.

PI_NAMEs: LEE, ESAK  (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: 3-Dimensional;Alzheimer's Disease;Animal Model;Architecture;Arthritis;Binding;Biological;Biology;Biomedical Engineering;Biophysics;Blood Vessels;Boston;Brain;Cell Culture Techniques;Cells;Clinical Research;Collaborations;Complex;Development;Dietary Fats;Disease;Drainage procedure;drug candidate;Exhibits;Experimental Models;Fibronectins;Fibrosis;Fluid Balance;Glaucoma;Goals;Homeostasis;Human;human disease;Immune System Diseases;Immunity;Immunologist;In Vitro;in vitro Model;in vivo;in vivo Model;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Intercellular Fluid;Intercellular Junctions;ITGA5 gene;lacteal;Ligands;Liquid substance;Lymph;lymph nodes;Lymphatic;Lymphatic Diseases;lymphatic drainage;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic Endothelium;Lymphatic function;Lymphatic System;lymphatic vessel;Lymphedema;Malignant Neoplasms;Mediating;Meningeal lymphatic system;Metabolic Diseases;Modeling;Morphogenesis;Morphology;Mus;Neurodegenerative Disorders;Neurons;Obesity;Organ;Outcome;Pediatric Hospitals;Pericytes;Permeability;Physiological;Protein Kinase;Regulation;Research Personnel;rho;ROCK1 gene;Role;screening;Signal Transduction;Small Intestines;Structure;therapeutic evaluation;three-dimensional modeling;Tissues;tool;Treatment Efficacy;two-dimensional;Universities;uptake;Vascular System;wasting

PROJECT_TITLE: Regulation of Lymphatic Endothelial Cell Junction and Drainage

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is the leading cause of dementia and affects millions of Americans, but it has no cure. The failure to develop drugs stems from a) the absence of accurate model systems that faithfully reflect human AD disease and can be used for research, b) the lack of knowledge of mechanisms that cause AD disease and its progression and c) the absence of a strategy to assess drugs that will address the disease. In this proposal, we will develop human AD organoid models, characterize disease mechanisms, and use them as a testing ground for treatments.

PI_NAMEs: MUOTRI, ALYSSON R.;SUBRAMANIAM, SHANKAR  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age of Onset;aged;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapeutic;American;Amyloid Beta A4 Precursor Protein;Appearance;Astrocytes;Autopsy;Biological Assay;Biological Models;Biophysics;Brain;causal model;Cell Line;Cells;Cessation of life;Chemicals;Clinical;Complex;Dementia;Development;Disease;Disease Marker;disease model;Disease Progression;drug candidate;drug development;drug discovery;drug efficacy;Drug Screening;Drug Targeting;efficacy evaluation;Evolution;Exhibits;Experimental Models;Failure;familial Alzheimer disease;FDA approved;Foundations;Gene Mutation;Genetic;Genetic Transcription;Goals;Human;human induced pluripotent stem cells;Impaired cognition;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;innovation;insight;Intervention;Investigation;Knowledge;Late Onset Alzheimer Disease;Lesion;Measurement;Memory Loss;Methods;Microglia;Modeling;Molecular;multimodality;Multiomic Data;multiple omics;mutant;Mutation;mutation correction;Nature;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;non-demented;novel;novel therapeutics;Organoids;Pathogenicity;Pathologic;patient derived induced pluripotent stem cells;Pharmaceutical Preparations;pharmacologic;Phenotype;presenilin-1;presenilin-2;Process;Research;Resolution;Role;screening;Severity of illness;Small Nuclear RNA;stem;success;System;Systems Biology;targeted treatment;Technology;Testing;Therapeutic;Time;tool;Validation;Work

PROJECT_TITLE: Nextgen AD Models, Endotypes, and Screening

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Serious Mental Illness;Suicide;Suicide Prevention;Violence Research

ORG_NAME: OUI THERAPEUTICS, INC

PHR: PROJECTIVE NARRATIVE Suicide is the second leading cause of death among youth in the US; however, effective suicide prevention programs are often difficult to disseminate because their implementation is labor intensive. In response to this gap, Oui Therapeutics seeks to determine the efficacy of Aviva-Y: a mobile technology tool designed to help youth reduce their risk of suicide.

PI_NAMEs: FEUERSTEIN, SETH ;SIMON, PATRICIA  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Administrative Supplement;adolescent suicide;aged;Award;Behavior;Caring;Cause of Death;chatbot;Clinical;clinical research site;Cognition;cognitive skill;Cognitive Therapy;cost;Data Collection;design;Development;digital;digital treatment;Educational process of instructing;efficacy evaluation;efficacy trial;electronic data;emotion regulation;Evaluation;Feeling suicidal;follow-up;Funding;High School Student;improved;Individual;Inpatients;interest;Interruption;Intervention;Investments;Measures;Mediation;Mediator;Mental Depression;Methods;mobile computing;Modeling;National Institute of Mental Health;Outcome;Outcome Study;Outpatients;Participant;Patient Recruitments;patient safety;Phase;phase 1 study;phase 2 study;predictive modeling;prevent;Prevention program;primary endpoint;Progress Reports;Protocols documentation;Randomized, Controlled Trials;Recording of previous events;reducing suicide;relapse prevention;Research;Research Contracts;response;Safety;Schedule;secondary endpoint;Self-Injurious Behavior;Site;skills;software development;suicidal;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Testing;Therapeutic;Thinking;Time;timeline;tool;treatment duration;treatment effect;treatment responders;treatment response;usability;Youth

PROJECT_TITLE: An Efficacy Trial of Mobile Technology for Reducing and Preventing Adolescent Suicide

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(16)-B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PHR: Approximately one-third of people living with dementia (PLWD) have highly “fragmented ambulatory care,” or care diffusely spread across many ambulatory providers. Fragmented ambulatory care may be an overlooked but modifiable contributor to some key problems in healthcare delivery for PLWD. The proposed project will determine whether fragmented ambulatory care contributes to underdiagnosis of dementia (including racial disparities in diagnoses) and to challenges with medication management for PLWD, while identifying novel opportunities for interventions to address fragmentation and improve outcomes.

PI_NAMEs: KERN, LISA M (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Address;Adopted;Adverse effects;Alzheimer's disease related dementia;Ambulatory Care;American;beneficiary;Brain scan;care coordination;care delivery;care fragmentation;Caregivers;Caring;catalyst;Clinical;clinical practice;cognitive function;Cohort Studies;Communication;Communities;Data;Data Collection;Dementia;dementia care;design;Development;Diagnosis;Disease;Disparity in diagnosis;Effectiveness;Electronic Health Record;Emergency department visit;epidemiology study;experience;Funding;Future;geographic disparity;Goals;Health and Retirement Study;health care delivery;health data;Health system;Hospitalization;improved;improved outcome;Individual;insight;Insurance Claim Review;Intervention;Interview;Knowledge;Link;Medicare;Medicare claim;Medication Management;Memory Loss;multidisciplinary;novel;Nurses;Outcome;Patients;Persons;Pharmaceutical Preparations;Physicians;Polypharmacy;Pragmatic clinical trial;preference;Provider;Race;racial disparity;Reasons for Geographic And Racial Differences in Stroke;Research Personnel;Role;Sampling;secondary analysis;stakeholder perspectives;Stroke;Structure;Testing;theories;therapy design;Time;Visit;Work;X-Ray Computed Tomography

PROJECT_TITLE: Understanding Ambulatory Care Utilization in Alzheimer's Disease and Related Dementias (ACUA)


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Orphan Drug;Rare Diseases;Wound Healing and Care

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Relevance to public health: Mutations in the gene encoding a Golgi localized calcium pumping ATPase result in a rare ulcerative disorder of the skin known as Hailey Hailey disease or familial chronic pemphigus for which there is no cure. The objective of this research is to develop key resources essential for therapeutic strategies that, if successful, will bring relief to a neglected population of patients.

PI_NAMEs: RAO, RAJINI  (contact)

PROGRAM_OFFICER_NAME: SHARMA, KARLIE ROXANNE

PROJECT_TERMS: Acantholysis;Address;Adherens Junction;Adhesions;Affect;Agonist;Alleles;ATP phosphohydrolase;Automobile Driving;autosome;Axilla;Bacterial Infections;Benign;Biochemical;Bulla;Ca(2+)-Transporting ATPase;Cell Adhesion;cell assembly;Cell Line;Cell model;Cells;Chest;Chronic;Clinical Treatment;Clinical Trials;CRISPR/Cas technology;Defect;Dermis;Desmosomes;Development;Diploidy;Disabling;Disease;disease phenotype;Dominant-Negative Mutation;drug development;effective therapy;efficacy testing;Endoplasmic Reticulum;Familial benign pemphigus;Funding Opportunities;Future;gain of function;gene therapy;Gene Transduction Agent;Genes;Golgi Apparatus;Heart Diseases;Homeostasis;Human;human disease;In Vitro;in vitro Model;Inguinal region;Inherited;inhibitor;Intercellular Junctions;Intervention;Ions;keratinocyte;knock-down;Knock-in;Knock-out;Laboratories;Lead;lentiviral-mediated;Lentivirus Vector;life span;loss of function mutation;Loss of Heterozygosity;Mammalian Cell;Modeling;Modification;Molecular Genetics;Monitor;mouse model;Muscular Dystrophies;Mutation;Mycoses;Neck;neglect;non-viral gene delivery;Organ;Pain;Pathologic;Pathway interactions;patient population;Patients;Pemphigus;Peptides;Phenotype;Pilot Projects;Positioning Attribute;Pre-Clinical Model;Proteins;Public Health;Quality of life;Rare Diseases;Recurrence;repaired;Research;Resources;response;restoration;Single-Gene Defect;Skin;skin disorder;Small Interfering RNA;small molecule;Sorting;Symptoms;System;targeted treatment;Testing;theories;Therapeutic;Tissues;Topical application;trafficking;Transfection;Ulcer;viral gene delivery;Viral Genes;Viral Vector;Yeasts

PROJECT_TITLE: Towards a targeted therapy for Hailey Hailey Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-1 (01)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health

ORG_CITY: Auburn

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: Project Narrative Severe problem behavior (e.g., aggression, self-injury) can greatly impair functioning, produce injury, and lead to placement in restrictive settings. The current proposal will examine the feasibility and preliminary efficacy of a number of methods for maintaining treatment gains in the face of common treatment challenges.

PI_NAMEs: FALLIGANT, JOHN  (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Aggressive behavior;Ambulatory Care Facilities;analog;Area;arm;Basic Science;Behavior;Behavior Therapy;Caregivers;Clinical;Clinical Trials;common treatment;Communication;Communities;Data;density;design;experience;Experimental Designs;Extinction;Frequencies;Future;Healthcare;Impairment;Individual;Injury;Inpatients;Intellectual functioning disability;Intervention;Investigation;Knowledge;Measures;Methods;New Agents;novel;Organism;Outcome;Persons;pilot trial;pre-clinical research;Prevalence;Procedures;Psychological reinforcement;Reinforcement Schedule;reinforcer;Relapse;Research;response;Risk;Schedule;Self-Injurious Behavior;Services;severe behavior problem;Stimulus;System;Techniques;Thinness;Training;Translating;Translational Research;United States;university student;Work

PROJECT_TITLE: A Single-Arm Pilot trial for Mitigating Relapse of Severe Problem Behavior

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Immunotherapy;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: EAST LANSING

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: PROJECT NARRATIVE This research proposal will elucidate mechanisms of immune evasion by papillomaviruses, mediated by induction of stress keratin K17, that permit for persistent infections and consequent cancer. Our studies are aimed at defining new therapeutic approaches to increase T-cell mediated killing of tumors, which will provide insights into how to enhance existing checkpoint blockade therapies by increasing tumor-infiltrating T cells. These studies are highly relevant to public health and will provide important insights for improving immunotherapy efficacy for other types of cancer as well.

PI_NAMEs: WANG, WEI  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Affect;cancer cell;cancer immunotherapy;cancer infiltrating T cells;Cancer Model;Cancer Patient;cancer type;carcinogenesis;Carcinoma;career;CD8-Positive T-Lymphocytes;Cell Communication;Cell Lineage;Cells;chemokine;chronic infection;Collaborations;CXCL10 gene;CXCL9 gene;CXCR3 gene;Data;Disease;disease model;Down-Regulation;Epithelial Cells;Epithelium;Faculty;Foundations;Future;Genes;Goals;head and neck cancer patient;high risk;HPV-negative head and neck cancer;Human;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immune;immune cell infiltrate;immune checkpoint blockade;Immune Evasion;Immune response;immunological status;immunoregulation;Immunosuppression;Immunotherapy;Impairment;improved;in vivo;Infection;Infiltration;insight;Institution;Integration Host Factors;interest;Intermediate Filaments;K22 Award;Keratin;keratinocyte;Laboratory mice;Learning;Lesion;Lymphoid;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant oropharynx neoplasm;Mediating;Melanoma;member;MHC Class II Genes;Modeling;Molecular;Mus;Myelogenous;neoplastic;neoplastic cell;new therapeutic target;novel;novel therapeutic intervention;Oncogenic;oral HPV-positive head and neck cancers;overexpression;Papillomavirus;Papillomavirus Infections;Patients;Phenotype;Play;Postdoctoral Fellow;prevent;Production;Prognosis;Proteins;Public Health;Publishing;Regulation;Reporting;Research;Research Personnel;Research Proposals;Resistance;response;Risk Factors;Role;Sampling;Scientist;Signal Pathway;Signal Transduction;Skin Cancer;Stress;T cell infiltration;T-Lymphocyte;Technology;Testing;The Cancer Genome Atlas;Tissue Microarray;transcriptomics;Transgenic Mice;tumor;tumor immunology;tumor microenvironment;tumor progression;tumor-immune system interactions;Tumor-infiltrating immune cells;Virus;Virus Diseases;Work

PROJECT_TITLE: Investigating the mechanism of K17-mediated immunosuppression in papillomavirus-induced cancers

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-R (J1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: PEDIATRICS

PHR: Project Narrative The majority of Alzheimer’s disease (AD) is late onset and idiopathic, the only current association is with primarily non-coding genomic single nucleotide risk variants. This project builds on our findings identifying a highly associated AD risk variant upstream of BIN1 as lying in a microglial specific enhancer and will define the microglial phenotype and resulting contribution to AD risk contributed by this enhancer. The project is relevant to the NIH’s mission to enhance life through targeting the contribution of genetic risk to the pathophysiology of AD onset and progression with a goal of novel therapeutic target identification.

PI_NAMEs: BLURTON-JONES, MATHEW MARK;COUFAL, NICOLE GABRIELE (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Amyloid beta-Protein;Apoptosis;Astrocytes;Axon;Brain;brain cell;Cause of Death;cell type;Cells;Central Nervous System;Cerebrospinal Fluid;Cerebrum;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Complex;CRISPR/Cas technology;Cytoskeleton;Data;Dementia;Development;Disease;Disease associated microglia;Disease Outcome;disease phenotype;Disease Progression;DNA;Dose;Early Intervention;effective therapy;Endocytosis;Enhancers;Environment;Epigenetic Process;exosome;falls;Functional disorder;Gene Expression;Gene Expression Profile;Genes;Genetic Risk;Genetic Transcription;genetic variant;Genetic Variation;genome wide association study;Genomic Segment;Genomics;Goals;Homeostasis;Human;Human Genetics;human induced pluripotent stem cells;humanized mouse;Immune;Immune response;improved;In Vitro;in vivo;in vivo Model;Incidence;induced pluripotent stem cell;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;Investigation;Late Onset Alzheimer Disease;Life;Link;loss of function;Maps;Measures;Mediating;Mediator;Methodology;Methods;Microglia;Mission;Modeling;Molecular;mouse model;multidisciplinary;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neurons;neuropathology;new therapeutic target;novel;Nucleic Acid Regulatory Sequences;Nucleotides;Onset of illness;Organoids;Outcome;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;Phagocytosis;Phenotype;Publishing;Regulation;response;risk variant;Role;Secondary to;single-cell RNA sequencing;stem cells;Stimulus;Synapses;synaptic function;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;therapeutic target;tissue culture;transcriptome;transcriptomics;translational model;United States;United States National Institutes of Health;Untranslated RNA;Variant;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Contribution of AD genetic risk and microglial BIN1 to tauopathy


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Physical Activity;Prevention

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: The PROVE Trial DCC Project Narrative  Wake Forest University School of Medicine proposes to serve as the data coordinating center for a five seven (Northwestern, Dartmouth, Emory, U Chicago, U Pittsburgh, U Arizona, and U Southern California) 2 × 2 facto- rial randomized clinical trial (N=386) examining home-based walking exercise vs. attention control and nitrate- rich beetroot juice vs. placebo in people with successful lower extremity revascularization for disabling periph- eral artery disease. The primary outcome is 6-month change in the 6-minute walk. We would assume responsi- bility for developing a web-based data management system, for overseeing quality control including conducting site visits, for analyzing data, and preparing manuscripts.

PI_NAMEs: AMBROSIUS, WALTER T (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: acronyms;Adherence;adjudication;Arizona;attentional control;Biometry;California;Cardiovascular Diseases;Chicago;Clinical;Clinical Trials;Clinical Trials Data Monitoring Committees;Clip;Collaborations;Collection;Communication;Conduct Clinical Trials;Consensus;Country;Data;Data Analyses;Data Coordinating Center;data management;Data Management Resources;Databases;Dedications;design;Development;Disabling;electronic data;Ensure;Environment;epidemiology study;Evaluation;Exercise;exercise intervention;experience;Failure;follow-up;Funding;Gait abnormality;Grant;hemodynamics;Home;Human Resources;improved mobility;innovation;International;Internet;Intervention;invention;Juice;Lead;Life;Lower Extremity;Maintenance;Manuals;Manuscripts;Master of Science;Measurement;medical schools;member;Methodology;Methods;Modeling;Monitor;Multicenter Studies;Multicenter Trials;Muscle;Nitrates;Nutraceutical;Online Systems;Operating System;operation;Outcome;Outcome Study;Participant;participant safety;Patient Outcomes Assessments;Peripheral arterial disease;Persons;Pharmaceutical Preparations;Placebos;prevent;primary outcome;Procedures;Process;Productivity;protocol development;Protocols documentation;Publications;quality assurance;Quality Control;Questionnaires;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recording of previous events;recruit;Reporting;Research Design;Research Personnel;revascularization;Safety;secondary outcome;Security;Site;Site Visit;skills;sound;Specific qualifier value;Standardization;Stress;success;Surveys;System;Talents;Technology;tool;Training;United States National Institutes of Health;Universities;Visit;Walking;web platform;website development

PROJECT_TITLE: 2/2 Improving Mobility After Revascularization in Peripheral Artery Disease: The IMPACT PAD Trial

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR (JA)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Pulmonary Fibrosis

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative: Optical Coherence Tomography (OCT) can provide low-risk, minimally invasive, volumetric visualization of microscopic ILD features, however, its clinical implementation is currently hindered by time and labor-intensive qualitative evaluation and manual feature segmentation techniques. This application aims to develop novel AI and deep learning-based imaging biomarkers for rapid, automated detection and robust, serial quantification of microscopic ILD features on OCT images, which could have major impact for early diagnosis and therapeutic strategizing. This career development proposal unifies my knowledge in optical imaging and advanced image analysis and will provide me with crucial training in clinical translation of AI-based quantitative optical imaging biomarkers needed to achieve my long-term scientific career goals.

PI_NAMEs: NANDY, SREYANKAR  (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: 3-Dimensional;Address;Agreement;Algorithms;Anatomy;Architecture;Artificial Intelligence;Award;Biometry;Biopsy;Blinded;Bronchoscopes;Budgets;burden of illness;career;career development;chronic respiratory disease;Clinical;clinical diagnosis;clinical implementation;Clinical Research;clinical translation;cohort;Data;Data Scientist;Data Set;deep learning;deep learning algorithm;Detection;Diagnosis;Diagnostic;diagnostic biomarker;Disease;disease diagnosis;disease natural history;disease prognosis;disorder subtype;Early Diagnosis;Early Intervention;Environment;Epidemiology;Equation;Evaluation;experience;Faculty;feature detection;fibrotic interstitial lung disease;follow-up;Foundations;Goals;Grant;High Resolution Computed Tomography;Histology;Histopathology;Hour;idiopathic pulmonary fibrosis;Image;Image Analysis;imaging biomarker;Imaging Techniques;improved;in vivo;Individual;instructor;Interstitial Lung Diseases;K-Series Research Career Programs;Knowledge;Location;Lung;Lung Diseases;Malignant Neoplasms;Manuals;Maps;Measures;medical schools;Medicine;Mentors;Mentorship;Methods;Microscopic;microscopic imaging;minimally invasive;Monitor;Morbidity - disease rate;mortality;mortality risk;novel;Optical Coherence Tomography;optical imaging;Patient-Focused Outcomes;Patients;Pattern;personalized therapeutic;Persons;Physicians;Physiology;Positioning Attribute;Postdoctoral Fellow;Prognostic Marker;Pulmonary function tests;Qualitative Evaluations;quantitative imaging;Research;Research Design;Research Personnel;Resources;responsible research conduct;Risk;segmentation algorithm;Sensitivity and Specificity;Spatial Distribution;Specificity;Specimen;Survival Rate;Techniques;Testing;Therapeutic;therapeutic biomarker;Therapeutic Intervention;Time;Tissues;Training;training data;translational scientist;treatment response;Usual Interstitial Pneumonia;Visualization;Work;Writing

PROJECT_TITLE: Quantitative Optical Imaging Biomarkers of Interstitial Lung Disease

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (JA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE RNA modifications by adenosine-to-inosine (A-to-I) editing are highly enriched and tightly regulated in the human brain, and their dysregulation has been implicated in the neuropathology of Alzheimer’s disease and related dementias (AD/RD). This proposal represents a critical step towards identifying functionally important A-to-I sites and involved in normal aging and AD/RD etiology, including those that are dynamically regulated throughout development as well as those that are genetically regulated across diverse ancestries and cell types. Results from this proposal will greatly expand neuropathological and genetic underpinnings of AD/RD, offering a springboard for more effective therapeutic targets for this devastating disease.

PI_NAMEs: BREEN, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: ADAR1;Address;Adenosine;Affinity;Aging;aging brain;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease related dementia;Amino Acid Sequence;base;Binding;Biological;Brain;brain cell;Cell model;cell type;Central Nervous System;cohort;Data;Deamination;Dementia;dementia risk;Development;Disease;Disease susceptibility;disorder risk;Double-Stranded RNA;DRADA2b protein;dsRNA adenosine deaminase;Enzymes;Etiology;Event;Gene Expression;gene function;Genetic;Genetic Diseases;genetic information;Genetic Risk;Genetic Variation;Genome;genome wide association study;genome-wide;genomic locus;Genomics;Genotype;Guanosine;Human;human induced pluripotent stem cells;immune activation;Individual;innovation;Inosine;insight;Knowledge;life span;Link;Maps;Methods;MicroRNAs;Modification;Molecular;Neurodegenerative Disorders;Neuroglia;Neurons;neuropathology;new therapeutic target;normal aging;Open Reading Frames;Outcome;Pathogenesis;pathological aging;Pathology;Play;posttranscriptional;Process;Protein Isoforms;Quantitative Trait Loci;Regional Anatomy;Regulation;Research;risk variant;RNA;RNA Editing;RNA Splicing;Role;Sampling;Severities;Site;spatiotemporal;Structure;targeted treatment;Therapeutic Intervention;therapeutic target;therapeutically effective;tool;Transcript;Transcriptional Regulation;transcriptome;transcriptomics;Translational Regulation;Translations;Validation;Work

PROJECT_TITLE: Leveraging large-scale genomics to dissect A-to-I editing in brain aging and Alzheimer's disease

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Immunization;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Pediatric;Prevention;Serious Mental Illness;Social Determinants of Health;Vaccine Related

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Although people with severe mental illness (SMI) are 3-10 times more likely to contract and die from vaccine- preventable disease, it remains unclear how best to address vaccine hesitancy in this population, largely because it is not known whether and how unique features of SMI impact hesitancy. Our studies will remedy this situation by 1) systematically characterizing unique aspects of hesitancy among people with SMI (vs. people with other psychiatric conditions and healthy people), 2) using cutting-edge machine-learning methods to learn what causes people with SMI to be vaccine hesitant and identify, in a data-driven manner, the most promising targets for hesitancy-reducing interventions, and 3) testing whether education about herd immunity, which improves willingness to vaccinate in the general population, is differentially efficacious for people with SMI vs. healthy people. Our studies will not only provide a rigorous test of prominent theories of vaccine hesitancy and their applicability to people with mental illness, but will also impact public health by laying strong empirical foundations for much-needed randomized controlled trials (RCTs) of interventions on vaccine hesitancy that are specifically tailored to people with SMI.

PI_NAMEs: BRONSTEIN, MICHAEL V (contact)

PROJECT_TERMS: 2019-nCoV;Active Learning;Address;adverse childhood events;Algorithms;Analysis of Variance;analytical tool;Anxiety;Attitude;Behavior;Binding;Calculi;Cessation of life;comparison group;Complement;Computer Models;Contracts;cost;COVID-19;Dangerousness;Data;Data Analyses;Data Science;Decision Theory;Disease;Education;Effectiveness;efficacious intervention;efficacy evaluation;evidence base;Evidence based intervention;experience;experimental study;Foundations;Frequencies;Fright;Future;General Population;Goals;Graph;Health;health belief;Herd Immunity;ideation;Illness impact;improved;Infection;infection risk;influenza virus vaccine;Intervention;Intervention Trial;Knowledge;Laboratories;Learning;machine learning algorithm;machine learning method;Measures;Mental Depression;Mental disorders;Minnesota;Misinformation;Modeling;Morbidity - disease rate;mortality;Motivation;National Institute of Mental Health;Natural Language Processing;neglect;news;Outcome;Paranoia;Participant;Pathway interactions;Persons;Pilot Projects;Population;Positioning Attribute;Psychological Models;Psychopathology;Psychosocial Factor;Public Health;Randomized, Controlled Trials;recruit;Research;severe mental illness;Severities;skill acquisition;Surveys;Symptoms;Testing;theories;tool;Training;Translating;Trust;Twitter;Uncertainty;uptake;Vaccinated;Vaccination;vaccine acceptance;vaccine hesitancy;Vaccines;Vulnerable Populations;willingness;Work

PROJECT_TITLE: Using Data Science to Quantify the Impact of Misinformation, Mistrust, and Other Key Psychosocial Factors on Vaccine Hesitancy Among Vulnerable People Experiencing Psychopathology

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Social Determinants of Health;Women's Health Research

ORG_CITY: Los Angeles

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Our project combines multiple measures of education to explore the education/ADRD relationship, noting that these relationships may vary as a function of diverse social environments—captured in our study as gender, country, and birth-cohort variation. Addressing issues of disparities in access to education will point to modifiable risk and protective factors for ADRD, both individual and policy, informed by how education relates to ADRD.

PI_NAMEs: FINCH, BRIAN K. (contact);FINKEL, DEBORAH G;GATZ, MARGARET

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: access disparities;Address;Adult;Aging;Alzheimer's disease related dementia;Birth;Characteristics;Classification;Cognition;Cognitive;cognitive function;cohort;Collaborations;Country;Data;Data Analyses;data harmonization;data sharing;Dementia;dementia risk;design;Development;Dimensions;Disparity;Education;Educational Status;Environment;Family;Female;Gender;gender difference;gender disparity;gene environment interaction;Generations;Genes;Genetic;Genetic Predisposition to Disease;Genotype;indexing;Individual;Inequality;innovation;intergenerational;International;Investigation;Measures;Mediator;men;Methods;Modeling;modifiable risk;Natural experiment;Natural Source;Nature;novel;Occupational;Occupations;Outcome;Parents;Policies;Process;protective effect;protective factors;Registries;Research;Resources;Risk Factors;Role;Sampling;skills;social;social disparities;Social Environment;Social Mobility;Structure;Testing;Time;trend;Twin Multiple Birth;Twin Studies;Variant;Woman

PROJECT_TITLE: Country, cohort, and gender disparities in the relationship between education and ADRD

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]