ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PROJECT_TERMS: Accountability;Address;Advisory Committees;Area;Articulation;Award;Behavioral;Biology;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer health disparity;Cancer health equity;cancer research center director;Catchment Area;Charge;Clinical;Clinical Research;Clinical Trials;Collaborations;collaborative environment;Communities;community engagement;Community Outreach;COVID-19 pandemic;Creativeness;Development;Disease;diversity and inclusion;Education;education research;Ensure;equity, diversity, and inclusion;ethnic diversity;Evaluation;experience;Extramural Activities;Faculty;Faith;Fostering;Foundations;Funding;Future;Gender;Goals;Grant;Growth;Health;Health equity research;improved;Infrastructure;Institution;Investments;Leadership;Malignant Neoplasms;Medicine;member;Mission;Monitor;multimodality;National Cancer Institute;NCI Center for Cancer Research;Outcome;outpatient facility;Peer Review;Policy Developments;Positioning Attribute;Principal Investigator;programs;Protocols documentation;Race;recruit;Research;research and development;Research Personnel;Research Training;Resource Allocation;Resource Sharing;Resources;response;Risk;Science;Services;Shapes;Social Distance;Strategic Planning;Structure;Students;success;survivorship;System;Technology;Training and Education;Translations;treatment trial;Trust;trustworthiness;Universities;Vaccination;Virginia;Vision;working group

PROJECT_TITLE: Leadership, Planning and Evaluation (LPE)


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSURGERY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Affective symptoms are at the core of numerous neuropsychiatric disorders, but their neurobiological basis is not well understood. Aberrant functioning in a dynamic brain network that supports emotions may underlie affective symptoms. A more fine-grained understanding of this network will be critical for advancing neuroanatomical models of emotions and for guiding the development of novel treatments for affective symptoms.

PI_NAMEs: CHANG, EDWARD  (contact);STURM, VIRGINIA EMILY

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Address;Adult;Affect;Affective;Affective Symptoms;Age;Anatomic Models;Anatomy;Animal Model;Anterior;Anxiety;Autonomic nervous system;Behavior;Behavioral;Biological Models;Biology;Brain;cingulate cortex;Color;Consensus;Coupled;daily functioning;Development;Dorsal;Electric Stimulation;Electrodes;Electroencephalography;emotion regulation;Emotional;emotional reaction;Emotions;Epilepsy;experience;Facial Expression;flexibility;Frequencies;Functional disorder;functional electrical stimulation;Generations;Goals;Grain;Hospitalization;Human;improved;Individual;innovation;Insula of Reil;interdisciplinary approach;Intractable Epilepsy;Investigation;Lateral;Length of Stay;Maps;Measures;Mental Depression;Methods;millisecond;Modeling;Monitor;Moods;mortality;multimodality;negative affect;network dysfunction;neural;Neuroanatomy;Neurobiology;neuroimaging;Neurons;neuropsychiatric disorder;novel;Operative Surgical Procedures;Participant;Patients;Pattern;Personal Satisfaction;Play;Population;positive emotional state;Property;Resolution;response;Role;Seizures;spatiotemporal;specific biomarkers;Standardization;Stimulus;Structure;success;support network;Symptoms;System;Testing;treatment response;unsupervised clustering;Video Recording;Work

PROJECT_TITLE: Spatiotemporal dynamics of the human emotion network

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

ORG_CITY: BALTIMORE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Behavioral health, broadly defined to include mental health and substance use, includes many of the most pressing public health problems of our time. The goal of this program is to produce the next generation of interdisciplinary researchers with rigorous training in the behavioral and social science foundations of behavioral health, computational and analytic methods to take full advantage of available data, and causal inference tools to identify the most effective interventions for behavioral health.

PI_NAMEs: STUART, ELIZABETH A. (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: behavioral health;data integration

PROJECT_TITLE: Data integration for causal inference in behavioral health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(50)]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: OAI, INC.

ORG_STATE: IL

PHR: OVERALL – Project Narrative The proposed OAI Consortium: Hazardous Waste Worker Training Program (HWWTP) and Environmental Careers Worker Training Program (ECWTP) aim to promote public health and prevent work-related harm through safety and health training to underserved populations and communities. The training advances the NIEHS mission to address hazardous waste site safety under the authority of the Superfund Amendments and Reauthorization Act (SARA). Both components work towards achieving the broad goals of Healthy People 2020 to “create social and physical environments that promote good health for all” and to support community health by “minimizing the risks to human health and the environment posed by hazardous sites.”

PI_NAMEs: HEPBURN, KRYSTAL LYNN (contact)

PROGRAM_OFFICER_NAME: PERSAUD, ERIC

PROJECT_TERMS: Address;Adult;African American population;Amendment;Ammonia;authority;Authorization documentation;Automobile Driving;Award;Awareness;Benchmarking;career;career development;Case Management;Chicago;Cities;climate change;Collaborations;Communicable Diseases;Communication;Communities;Community Health;Computers;cultural competence;Decision Making;Dedications;design;Disadvantaged;Disparity;Ear;Education;Electronics;Emergency Situation;Employment;Employment Opportunities;empowerment;Ensure;Environment;Environmental Health;Evaluation;experience;Exposure to;Eye;Face;Family;Fee-for-Service Plans;First Aid;first responder;follow-up;Gases;Goals;hazard;Hazardous Substances;Hazardous Waste;Hazardous Waste Operations and Emergency Response;Hazardous Waste Sites;Health;health disparity;Health Hazards;health training;Healthy People 2020;Hour;Human;Human Resources;Illicit Drugs;Imprisonment;improved;Individual;Industry;innovation;Instruction;instructor;interest;Investments;job market;Kansas;Knowledge acquisition;Laboratories;Latinx;Leadership;Learning;Life;Limited English Proficiency;literacy;manufacture;Mathematics;member;Mentors;Methods;Mission;Modeling;Muslim population group;Nail plate;National Institute of Environmental Health Sciences;Occupations;Oils;Overdose;Participant;patient home care;peer;Personal Behavior;Physical environment;Population;Positioning Attribute;prevent;Prevention;Process;Program Evaluation;programs;Public Health;recruit;Recycling;remediation;Research;resilience;Resources;response;Risk;risk minimization;Safety;screening;Services;Site;skills;skills training;smartphone application;Social Environment;student retention;Students;Superfund;System;Target Populations;Technology;Trainers Training;Training;training opportunity;Training Programs;trend;Underemployment;underserved community;Underserved Population;Unemployment;Vietnamese;Vocational Guidance;volunteer;wasting;Woman;Work;Workplace

PROJECT_TITLE: OAI Consortium: Hazardous Waste Worker Training Program (HWWTP) and Environmental Career Worker Training Program (ECWTP)


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Patient Safety

ORG_CITY: RICHMOND

ORG_STATE: VA

PI_NAMEs: RANDALL, LESLIE M (contact)

PROJECT_TERMS: Age;Artificial Intelligence;Cancer Center;Cancer Center Support Grant;central database;Child;Clinical;Clinical Cancer Center;Clinical Data;Clinical Nursing Research;Clinical Practice Guideline;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Communities;community based research;Complex;Computer software;Computerized Medical Record;Conceptions;Data;Data Collection;data integrity;data management;data repository;Development;Directories;Discipline of Nursing;Disease;Elements;Employee;Enrollment;Ensure;ethnic minority;Fostering;Good Clinical Practice;human old age (65+);human subject;Human Subject Research;improved;Individual;Industry;Informed Consent;Institution;Intervention;Intervention Studies;Investigational New Drug Application;investigator-initiated trial;Investments;Leadership;Life Cycle Stages;life span;Malignant Neoplasms;Massey Cancer Center at the Virginia Commonwealth University;Minority;Molecular Target;Monitor;Multicenter Trials;National Clinical Trials Network;Oncology;Participant;participant safety;patient safety;patient screening;Patients;Peer Review;Performance;phase I trial;Policies;Process;Protocol Compliance;protocol development;Protocols documentation;Quality Control;racial minority;recruit;Regulation;Reporting;Research;Research Personnel;research study;Research Support;Resources;Risk;Safety;Science;Services;Strategic Planning;System;Time;Training;Training and Education;Translational Research;Translations;United States National Institutes of Health;Universities;Virginia;Woman;working group

PROJECT_TITLE: Clinical Protocol and Data Management (CPDM)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Opioids;Substance Misuse

ORG_CITY: BINGHAMTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

ORG_STATE: NY

PHR: PROJECT NARRATIVE This project will determine how ethanol drinking is differentially affected by the dynorphin/kappa opioid receptor system in the nucleus accumbens shell across its rostro-caudal axis. Using a multidisciplinary approach, we will investigate the hypothesis that activation of kappa opioid receptors in the rostral shell elicits a hedonic state and inhibits ethanol drinking, by preferentially modulating serotonin, while activation in the caudal shell instead drives a dysphoric state and increases ethanol drinking, by preferentially modulating dopamine. The results of these studies could ultimately have transformative implications for public health, by facilitating the design of pathway- specific therapeutics to revolutionize treatment for alcohol use disorder.

PI_NAMEs: BARSON, JESSICA ROSE;KARKHANIS, ANUSHREE N (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Affect;Affective;alcohol abuse therapy;Alcohol consumption;alcohol use disorder;Amygdaloid structure;approach behavior;approach/avoidance behavior;Attenuated;Automobile Driving;avoidance behavior;Behavior;Behavioral;Brain region;Data;Dependence;design;Dopamine;dopamine system;dopaminergic neuron;drinking;drinking behavior;Dynorphins;Equilibrium;Excision;experimental study;Genetic;Goals;hedonic;Immunohistochemistry;In Situ Hybridization;interdisciplinary approach;kappa opioid receptors;Literature;Measures;Mediating;Modeling;Molecular Biology;monoamine;motivated behavior;negative affect;Negative Reinforcements;neuromechanism;Neurons;neuroregulation;neurotransmission;Nucleus Accumbens;Optics;optogenetics;Pathway interactions;Periodicity;pharmacologic;Pharmacology;presynaptic;Public Health;Receptor Activation;Receptor Inhibition;Rewards;Role;Scanning;selective expression;Serotonin;Signal Transduction;System;Techniques;Therapeutic;transmission process;Viral

PROJECT_TITLE: Mechanisms of rostrocaudal differences in accumbal kappa opioid receptor effects on ethanol drinking

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: Dayton

ORG_NAME: RNET TECHNOLOGIES, INC.

ORG_STATE: OH

PHR: PUBLIC HEALTH RELEVANCE The proposed software will help developers overcome the limitations of current computing hardware to design more accurate deep learning models for use in clinical diagnostics. These models will be able to analyze very large digitized images of glass slides to aid pathologists in tasks like cancer detection. The ability to analyze these images in their entirety will accelerate the development of accurate AI based diagnostics.

PI_NAMEs: SABIN, GERALD  (contact)

PROGRAM_OFFICER_NAME: ASHMONT, KARI RICH

PROJECT_TERMS: Acceleration;Adoption;Architecture;Area;Artificial Intelligence;Cancer Detection;Classification;Clinical;clinical diagnostics;cohort;Complex;Computer Hardware;Computer software;Computerized Medical Record;Computing Methodologies;Data;Data Set;deep learning;deep learning model;design;Development;Diagnosis;Diagnostic;digital pathology;Dimensions;Evolution;gigabyte;Glass;Goals;Government Agencies;Healthcare;Healthcare Systems;High Performance Computing;high resolution imaging;Human;Image;Image Analysis;Imaging problem;implementation efforts;interest;Investments;Label;Laboratories;Learning;Lung;lung cancer screening;Machine Learning;machine learning framework;Magnetic Resonance;Marketing;Medical;Medical Imaging;Memory;Methods;Modeling;Movement;network architecture;neural network;Neural Network Simulation;next generation;novel;operation;Outcome;Pathologist;Pathology;pathology imaging;Patients;Performance;Phase;Play;portability;Process;prototype;public health relevance;Research;Research Personnel;Resolution;Role;screening;Screening for Prostate Cancer;Services;Slice;Slide;software development;Software Framework;software infrastructure;spatial relationship;Stream;Structure;System;Techniques;Technology;TensorFlow;Time;tool;Training;training data;tumor;user-friendly;Visualization software;X-Ray Computed Tomography

PROJECT_TITLE: Enabling Next Generation Machine Learning for Large Scale Image Analysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-Z(10)B]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke;Telehealth

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: Project Narrative  Upper-limb paresis is the most common impairment following a stroke affecting 75% of stroke survivors, which can be more prominent in one of the two limbs. It is clinically important that stroke survivors continue to practice the use of the stroke-affected limb in their home and community settings to maintain the functional level learned in the clinic, but currently, there exists no effective, practical clinical tool. In this project, we propose to develop and validate an mHealth technology that will monitor real-world upper limb activity by leveraging our novel finger-worn accelerometer sensors and provide individually-tailored feedback to encourage affected limb use.

PI_NAMEs: LEE, SUNGHOON  (contact)

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Accelerometer;Activities of Daily Living;Affect;arm;arm movement;Behavior;behavior change;Body Composition;Brachial Paresis;care providers;Cause of Death;Cellular Phone;chronic stroke;Clinic;Clinical;cloud based;cloud platform;community setting;cost;Data;data communication;Data Set;data sharing;data visualization;design;Development;disability;dosage;Effectiveness;Environment;Evaluation Studies;Feedback;Fingers;functional gain;Functional impairment;Future;Goals;Hand;Hand functions;Health system;Health Technology;hemiparesis;Home;Human;human centered design;Impairment;improved;Individual;industry partner;insight;Intervention;Investigation;Learning;Limb structure;machine learning algorithm;mHealth;mhealth interventions;Monitor;Motor;motor recovery;Motor Skills;Movement;Network-based;novel;Occupational Therapy;Outcome;Patients;Performance;personalized management;Phase;Physical therapy;post stroke;Process;Provider;Recovery;Recovery of Function;recruit;Rehabilitation therapy;Research;Secure;sensor;Stroke;stroke survivor;System;Technology;tool;Upper Extremity;upper limb hemiparesis;Upper limb movement;usability;wearable data;wearable device;wearable sensor technology;web platform;Withdrawal

PROJECT_TITLE: Achieving Optimal Motor Function in Stroke Survivors via a Human-Centered Approach to Design an mHealth Platform


NIH_SPENDING_CATS: Cancer

PI_NAMEs: MARTINS, RENATO  (contact)

PROJECT_TERMS: Accountability;Adult;anti-cancer research;authority;Biometry;Cancer Center;Cancer Center Support Grant;Childhood;Clinical;Clinical Cancer Center;Clinical Research;Clinical Trials;Conduct Clinical Trials;Data;Dedications;design;Disease;Effectiveness;Ensure;Evaluation;expedited review;experience;Faculty;Goals;Hematology;Individual;Industry;Institution;Institutional Review Boards;Internal Medicine;Leadership;Malignant Neoplasms;Massey Cancer Center at the Virginia Commonwealth University;Medicine;meetings;mid-career faculty;Modification;Monitor;multidisciplinary;Notification;Oncology;Operative Surgical Procedures;Palliative Care;Pathology;pediatric department;Pediatric Oncology;Peer Review;Population Sciences;Principal Investigator;Procedures;Process;Productivity;Protocols documentation;Qualifying;Radiation Oncology;Research;Research Personnel;research study;response;Review Committee;Risk;Safety;sound;System;Universities;Virginia;working group

PROJECT_TITLE: Protocol Review and Monitoring System (PRMS)


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Lung;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE Heart failure (HF) is a chronic condition leading to >1 million hospitalizations in the U.S. per year due to fluid build-up in the body’s tissues including the lungs. Approximately half of patients with HF have a preserved pump function (HFpEF) and this group of patients is especially difficult to diagnose and treat. Our research is aimed at understanding how lung ultrasound examinations can improve the early identification of lung fluid in HFpEF in order to better guide therapy, improve quality of life, and reduce hospitalizations for fluid overload.

PI_NAMEs: PLATZ, ELKE  (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Acute;Adult;adverse outcome;Affect;Atrial Fibrillation;Auscultation;Biological Markers;Cause of Death;Cellular Phone;Chronic;Clinical;Clinical assessments;cohort;comorbidity;Computerized Medical Record;Congestive Heart Failure;cost;Death Rate;Detection;Devices;Diagnosis;Diagnostic Procedure;diagnostic strategy;Diuresis;Early Diagnosis;Early identification;Early Intervention;Early treatment;Echocardiography;economic impact;EFRAC;Emergency Department patient;Evaluation;Event;evidence base;experience;Fluid overload;Funding;Future;Generations;Goals;Health;Heart failure;hemodynamics;high risk;Hospitalization;Image;improved;Information Dissemination;innovation;Laboratories;Learning;Liquid substance;Lung;Measures;Methods;Monitor;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;multidisciplinary;Natriuretic Peptides;novel;novel strategies;Obesity;Online Systems;Outpatients;patient subsets;Patients;Physical Examination;Play;point of care;Population;preservation;Prevalence;Prior Therapy;pro-brain natriuretic peptide (1-76);prognostic;prognostic value;Protocols documentation;Publications;Pump;Quality of life;Regulation;Reporting;Research;Risk;Risk Marker;Role;support tools;Symptoms;Syndrome;technology validation;Thoracic Radiography;Time;Tissues;tool;ultrasound;Work

PROJECT_TITLE: Improving Pulmonary Congestion Assessment in Heart Failure with Preserved Ejection Fraction

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE The ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer disease. ApoE4 exacerbates not only amyloid pathology but also tau-mediated neurodegeneration. Our proposal seeks to identify small molecule apoE4 inhibitors, thereby reducing apoE4-related pathogenic effects for AD therapy.

PI_NAMEs: CHUNG, THOMAS D Y;LI, YONGHE  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: 3-Dimensional;abeta accumulation;Abeta synthesis;Actins;Affect;Age Years;Alleles;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapeutic;Alzheimer's disease therapy;amyloid pathology;analog;Animals;Apolipoprotein E;apolipoprotein E-4;Astrocytes;Benchmarking;Biochemical;Biological;Biological Assay;Blood - brain barrier anatomy;Brain;Catalogs;Cell model;Cells;Cerebrum;Chemicals;cheminformatics;Chemistry;Cognitive deficits;Collaborations;Complement;Critical Pathways;cytotoxic;cytotoxicity;Dementia;dementia risk;Detection;Disease;Down-Regulation;drug candidate;drug discovery;Drug Kinetics;Evaluation;Future;Genes;Genetic Complementation Test;genetic risk factor;Genotype;high throughput screening;human induced pluripotent stem cells;improved;in vivo;induced pluripotent stem cell;inhibitor;Late Onset Alzheimer Disease;Lead;Life;Luciferases;Measures;Modeling;Monitor;Morphologic artifacts;Neurofibrillary Tangles;neuronal survival;Neurons;novel;novel therapeutic intervention;novel therapeutics;Organoids;Pathogenicity;Pathologic;Penetrance;Penetration;Performance;Pharmaceutical Preparations;Phenotype;Positioning Attribute;pre-clinical;programs;Property;Protein Fragment;Proteins;Reporter;response;Risk;Rodent;scaffold;scale up;Senile Plaques;Signal Transduction;small molecule;small molecule libraries;Synaptic plasticity;tau Proteins;tau-1;Tauopathies;Therapeutic Effect;therapeutic target;Toxic effect;Treatment Efficacy

PROJECT_TITLE: Discovery of apoE4 modulators for Alzheimer’s disease therapy

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS-R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE High levels of interparental conflict account for much of the increased risk for mental health disorders and problems in children who experience parental separation/divorce, which has significant individual and societal costs. This project combines prior research and new input from family court judges, administrators, and service providers, and high-conflict parents to design and pilot test a contextually appropriate, scalable intervention to reduce post-separation/divorce interparental conflict. Results of this research will provide the foundation for an R01 that will support a large-scale trial of this intervention.

PI_NAMEs: O'HARA, KAREY ;WOLCHIK, SHARLENE ANN (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Address;Administrator;Adopted;Adoption;Age;Child;Child Mental Health;Collaborations;Conflict (Psychology);County;court;Data;Decision Making;design;Development;Diagnosis;digital;Disease;Divorce;divorce/separation;effectiveness/implementation trial;evidence base;Evidence based intervention;experience;Exposure to;Family;Focus Groups;Foundations;Goals;heuristics;High Prevalence;high risk sexual behavior;Hour;human centered design;Hybrids;implementation framework;implementation outcomes;improved;Individual;interest;Intervention;intervention refinement;Intervention Trial;Interview;Investigational Therapies;Legal;life span;Link;Longitudinal Studies;Mediator;Mental disorders;Mental Health;Methods;National Institute of Mental Health;Outcome;Parents;Partnership Practice;peer;Persons;pilot test;Population;prevent;Process;programs;prototype;psychosocial;Public Health;Questionnaires;Randomized;Randomized, Controlled Trials;Recording of previous events;Reporting;Research;Research Personnel;Resources;Risk;service providers;Services;Shorthand;skills;societal costs;Strategic Planning;Structure;Subgroup;substance use;suicidal;Surveys;System;Techniques;Testing;theories;therapy design;therapy development;Treatment/Psychosocial Effects;United States National Institutes of Health;usability

PROJECT_TITLE: Theory-driven, human-centered design-based adaptation and pilot test of an intervention to reduce interparental conflict to prevent children's mental health problems after separation/divorce


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative This proposal investigates the mechanisms by which visual information is selectively filtered in a arousal state- dependent at the first synapse between eye and brain. We will test the hypothesis that serotonin plays an important role in modulating the strength of different channels of retinal information. A detailed understanding of this process will be important for understanding how attention to visual stimuli can be restored in neurological disorders such as stroke and optic nerve injury.

PI_NAMEs: ANDERMANN, MARK L (contact);CHEN, CHINFEI

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Affect;Animals;Arousal;Attention;awake;Axon;base;Behavior;Behavioral;Biology;Brain;Calcium;cell type;Cells;Code;Collaborations;Data;Dorsal;dorsal raphe nucleus;Environment;Eye;FOXP2 gene;Genetic;genetic manipulation;Geniculate body structure;Glutamates;Image;imaging modality;In Vitro;in vivo;Laboratory Finding;Location;luminance;Mediating;Motion;Mus;Nature;Neocortex;nerve damage;Nervous System Disorder;Neurons;neuroregulation;Optic Nerve;Optic Nerve Injuries;optic nerve regeneration;Optic tract structure;optogenetics;patch clamp;Pattern;Perception;pharmacologic;Photometry;Play;Population;preference;presynaptic;Presynaptic Terminals;Primates;Process;receptive field;receptor;Resolution;response;Retina;retinal axon;Retinal Ganglion Cells;retinal prosthesis;Role;Sensory;Serotonin;Serotonin Receptor 5-HT1B;sight restoration;Signal Transduction;Site;Stimulus;Stroke;Synapses;Testing;Thalamic structure;transmission process;two-photon;Visual;Visual Cortex;visual information;Visual Pathways;visual processing;visual stimulus;Work

PROJECT_TITLE: State-dependent modulation of retinothalamic axonal boutons


NIH_SPENDING_CATS: Aging;Autoimmune Disease;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Multiple sclerosis, a neurological disease affecting the brain and spinal cord, also impacts the eyes, causing visual impairment and decreasing quality of life. Through study of newly discovered changes in the eyes of people with and without multiple sclerosis this work will establish how this, and other neurodegenerative diseases cause visual impairment. We will also develop objective and non-invasive measures of eye structure that will help treating physicians predict clinical progression and treat visual symptoms in affected people. Furthermore, this work will develop retinal imaging techniques that simplify detection of structural and functional changes that will be applicable to the study of more patients with more diseases, and by more physicians and researchers.

PI_NAMEs: MOSS, HEATHER ELSPETH (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Acceleration;adaptive optics;Address;Adult;Affect;Age;aged;Atrophic;Autopsy;Behavior;Biological;Biological Markers;Blindness;Brain;candidate marker;Caring;Cessation of life;Clinic;Clinical;clinical predictors;Clinical Research;clinically relevant;Comparative Study;Confocal Microscopy;cost;Coupled;Detection;detection method;Diagnosis;Disease;Disease Progression;Electroretinography;Etiology;Experimental Models;Eye;feature detection;Functional disorder;Future;ganglion cell;Glaucoma;Glean;High Prevalence;Human;Image;imaging biomarker;Imaging Device;Imaging Techniques;Immunofluorescence Immunologic;In Vitro;in vivo;Inflammatory;Investigation;Lesion;life time cost;Light;Location;Longitudinal Studies;Measurement;Measures;meetings;Methods;Microscopy;middle age;Minority Groups;Monitor;Multiple Sclerosis;multiple sclerosis patient;Nature;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;novel;older adult;Ophthalmoscopy;Optic Nerve;Pathologic;Pathology;Patients;Perimetry;Persons;Phenotype;Photoreceptors;Physicians;Population;Productivity;Protocols documentation;Quality of life;Research;Research Personnel;Resolution;Retina;Retinal Ganglion Cells;retinal imaging;Sample Size;Sampling;Scanning;Site;Societies;Specificity;Spinal Cord;Structure;Study Subject;Symptoms;Testing;Thinking;Time;Translations;Vision;Visual;Visual Acuity;Visual disability;Visual impairment;Visual Pathways;Visualization;Work

PROJECT_TITLE: Beyond ganglion cells: Novel foveal avascular zone features in MS with implications for vision loss


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: TAMPA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: PROJECT NARRATIVE Protecting macular retinal pigment epithelium (RPE) and photoreceptors could preserve central vision in patients with the dry form of Age-related Macular Degeneration (dry-AMD). We will investigate the role of the modified form of erythropoietin, EPO-R76E, in suppressing dry-AMD phenotypes. Understanding the molecular impact of EPO-R76E in the RPE will open new therapeutic avenues for preventing or perhaps reversing vision-loss in dry- AMD.

PI_NAMEs: BISWAL, MANAS R (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: 3-nitrotyrosine;5'-AMP-activated protein kinase;Adipocytes;Age;Age Months;age related;Age related macular degeneration;aged;Aging;Animal Model;Anti-Inflammatory Agents;Antioxidants;Atrophic;Bioenergetics;Biogenesis;Biological;Biological Markers;Blindness;Cell Death;cell type;Cells;Cessation of life;Cholesterol;Choroid;clinical phenotype;comparison control;Complement;cytokine;Cytoprotection;Dark Adaptation;delivery vehicle;Deposition;Developed Countries;Diet;digital;Disease;Dryness;Economic Burden;effective therapy;Effectiveness;Electron Microscopy;Enzyme-Linked Immunosorbent Assay;Erythropoietin;Eye;Fatty acid glycerol esters;Flow Cytometry;Functional disorder;functional improvement;fundus imaging;ganglion cell;Gene Activation;Genes;Genetic Polymorphism;Genetic Transcription;Genotype;geographic atrophy;Global Change;Glutathione;Harvest;Health;healthcare burden;Histologic;Homeostasis;IL17 gene;IL18 gene;immune cell infiltrate;Immunohistochemistry;Impairment;in vivo evaluation;Inflammation;Inflammatory;interest;Interleukin-1 alpha;Interleukin-10;Interleukin-6;Ions;Iron;Kidney;Lipid Peroxidation;Lipids;LoxP-flanked allele;macula;Measures;Mediating;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Monitor;mouse model;Mus;Mutation;Nonexudative age-related macular degeneration;novel;novel therapeutics;Older Population;oxidative DNA damage;Oxidative Stress;Oxidative Stress Induction;Pathology;Pathway Analysis;Pathway interactions;Patients;Phenotype;Photoreceptors;Play;preservation;prevent;preventive intervention;productivity loss;protective effect;Protein Isoforms;Proteins;Proteomics;Quality of life;Recombinant adeno-associated virus (rAAV);Reporting;Research;response;Retina;Retinal Degeneration;retinal imaging;Risk;RNA;Role;Serotyping;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Stains;Stress;Structure;Structure of retinal pigment epithelium;subretinal injection;Symptoms;Techniques;Testing;Therapeutic Intervention;Time;Tissue Harvesting;TNF gene;Transgenic Mice;Variant;vector;Vision;Visual Acuity;visual dysfunction;Visualization;Western Blotting

PROJECT_TITLE: Elucidating the mechanism of erythropoietin (EPO) in mitigating Dry-AMD pathophysiology

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: The Training Program in Environmental Health Biostatistics at the Harvard T. H. Chan School of Public Health prepares pre-doctoral and postdoctoral fellows for research in the application of biostatistics, statistical genetics and genomics, and data science to the environmental health sciences. The Program combines first class training in biostatistical theory and methods, formal training in computer science and environmental health, practical experience in environmental health collaborations in interdisciplinary team science settings, and rigorous training in reproducible science. The Program provides trainees with skills necessary for scientific leadership in interdisciplinary settings, focusing on skills for project management, grant writing, and other skills needed for scientific leadership.

PI_NAMEs: COULL, BRENT ANDREW (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Biometry;Training

PROJECT_TITLE: Graduate Training in Biostatistics

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(T)]


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: COLLEGE PARK

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: PROJECT NARRATIVE: Targeting the molecular interactions of structural exopolysaccharides in bacterial biofilms is a promising new approach to treat persistent and hospital acquired infections resulting from biofilm infections. This proposed research will develop new tools to identify critical protein- exopolysaccharide binding interactions that occur in live bacterial biofilms and will also identify novel biocatalyst capable of breaking down biofilm exopolysaccharides through functional metagenomic screening and through protein engineering to improve the catalytic activity of existing biofilm dispersal agents.

PI_NAMEs: POULIN, MYLES B (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: analog;Antibiotics;Area;Bacterial Infections;Binding;Binding Proteins;biochemical tools;carbohydrate binding protein;carbohydrate receptor;Cell Communication;Cells;Chemicals;Engineering;Enzymes;Glycoside Hydrolases;Goals;Healthcare;Human;Immune system;improved;Infection;insight;Label;Laboratories;metagenome;Metagenomics;Microbial Biofilms;Molecular Target;Mutagenesis;Nosocomial Infections;novel;novel strategies;Protein Engineering;Proteins;Research;Role;screening;Site;Therapeutic;Therapeutic Uses;tool

PROJECT_TITLE: Chemical and biochemical tools to study the functions of exopolysaccharides in bacterial biofilms


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Digestive Diseases;Microbiome;Nutrition;Pediatric;Prevention;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative: Hirschsprung disease is a life-threatening birth defect where the enteric nervous system is missing from distal bowel. Symptoms and outcomes vary quite dramatically among affected children, but the reason for varied Hirschsprung disease symptoms and outcomes is not known. We discovered serendipitously that an inbred Hirschsprung disease mouse model lives 5-fold longer in Philadelphia than in Montreal and now test the hypothesis that diet, gut microbes and metabolites influence fundamental Hirschsprung disease mechanisms to impact bowel barrier function and survival.

PI_NAMEs: HEUCKEROTH, ROBERT O (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: abdominal distension;Affect;Anatomy;anti-microbial peptide;Bacteria;beneficial microorganism;Biological Assay;candidate identification;Cause of Death;Cell Physiology;Cessation of life;Child;Clinical Trials;Colon;Complex;Congenital Abnormality;Congenital Megacolon;Constipation;Dangerousness;Data;Defect;design;Diet;Dietary Component;Disease;disease model;Disease Outcome;Distal;Enteric Nervous System;Enterocolitis;Environment;Epithelial Cells;Epithelium;Excision;Exclusive Breastfeeding;Failure;fecal transplantation;Feces;feeding;Food;Functional disorder;Genetic;Germ-Free;Goals;Growth;gut inflammation;gut microbes;Human;human data;improved;improved outcome;In Vitro;in vivo;Inbreeding;Inflammation;innovation;Institution;Intestines;Length;Life;Microbe;microbial;mouse model;Mucins;mucosal microbiota;Mucous body substance;Mus;Nervous System;non-genetic;novel therapeutic intervention;Nutrient;Operative Surgical Procedures;Outcome;Pediatric Hospitals;Philadelphia;Positioning Attribute;Postoperative Period;premature;prevent;Probiotics;Property;Proteins;Quebec;Recurrence;Risk;RNA;Sepsis;Severities;small molecule;Symptoms;Testing;Transition zone of anal mucous membrane;Transplantation;Universities;Vomiting

PROJECT_TITLE: Defining non-genetic mechanisms that prevent death in a Hirschsprung disease mouse model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Digestive Diseases;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative  Minimally invasive liver surgery (MILS) has many potential advantages but liver deformation leads to significant difficulties in localizing tumors and avoiding main vessels accurately. This project aims to develop a novel surgical navigation approach as a tool to guide MILS intraoperatively. Novel computer vision and machine learning algorithms, including GPU-based non-rigid simultaneously localization and mapping (SLAM), learning- based landmarks recognition and non-rigid registration will be developed to compensate for live deformation and map preoperative data to the patient’s anatomy in real-time during MILS.

PI_NAMEs: ZHOU, HAOYIN  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;Anatomy;Applications Grants;Area;Award;Basic Science;Binocular Vision;Blood;cancer diagnosis;Carbon Dioxide;career;career development;catalyst;Clinical;Clinical Research;Color;Compensation;Computer software;Computer Vision Systems;Data;deep learning;Dependence;design;detection method;Devices;Diagnosis;Diagnostic;disorder prevention;Environment;Excision;experience;Family suidae;Feedback;frontier;Funding;Goals;haptic feedback;Healthcare;Hemorrhage;Hepatic;Hospitals;human disease;Image;image guided;image guided therapy;image processing;image registration;imaging facilities;improved;in vivo;International;Knowledge;Laboratories;Laparoscopes;Laparoscopy;Learning;Liver;Liver neoplasms;Location;Machine Learning;machine learning algorithm;machine learning method;Malignant neoplasm of liver;Maps;Medical;Medical Imaging;medical schools;Medicine;Mentors;Methods;minimally invasive;Modeling;Motion;Multimodal Imaging;Navigation System;novel;Operating Rooms;Operative Surgical Procedures;Patients;Phase;Pneumoperitoneum;Postdoctoral Fellow;postoperative recovery;Procedures;professor;programs;prototype;Psyche structure;radiologist;reconstruction;Recovery;Research;research and development;research clinical testing;Research Personnel;Research Support;Respiration;Robotics;Solid;Stress;Structure;Supervision;Surface;Surgeon;Surgical Instruments;symposium;System;Technology;technology development;Texture;three-dimensional visualization;Time;tissue reconstruction;Tissues;Titan;tool;Training;Training and Education;Translational Research;Trauma patient;tumor;Ultrasonography;Uncertainty;United States National Institutes of Health;uptake;virtual patient;Visualization;Woman;Work;Writing;X-Ray Computed Tomography

PROJECT_TITLE: Real-time Non-Rigid 3D Reconstruction and Registration for Laparoscopic-guided Minimally Invasive Liver Surgery


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Women's Health Research

ORG_CITY: JACKSON

ORG_NAME: JACKSON STATE UNIVERSITY

ORG_STATE: MS

PHR: Program Director/Principal Investigator (Last, First, Middle): Liu, Yiming  Over the past years numerous microRNAs have been reported as biomarkers associated with various medical conditions. The current golden standard for microRNA assay, i.e., quantitative reverse transcription polymerase chain reaction (RT-qPCR), has disadvantages such as inadequate assay accuracy and high-assay costs. We propose herein to develop a novel analytical strategy based on the reliable UPLC- MS/MS technique to achieve highly sensitive absolute quantification of targeted microRNAs in biological samples, thus fostering the biomedical research and full validation of these emerging disease biomarkers. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: LIU, YIMING  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: 1-Methyl-4-phenylpyridinium;Acids;Adenine;Affinity;analytical method;Azacitidine;base;Biological;Biological Assay;Biological Markers;Biology;Biomedical Research;Breast Cancer Cell;Breast Epithelial Cells;Calibration;cancer biomarkers;cancer cell;Cell Culture Techniques;Cell Line;Cell model;Cells;Characteristics;Chemistry;Cisplatin;Clinical;cost;cost effective;cost effectiveness;Data;design;Development;Disadvantaged;Discrimination;Disease;disease diagnosis;DU145;Enzymes;Evaluation;Exclusion;exosome;Fluorescence;Fostering;Future;Goals;Hydrolysis;improved;innovation;Intoxication;Ion-Exchange Chromatography Procedure;Label;Liquid Chromatography;logarithm;magnetic beads;Magnetism;MCF10A cells;MCF7 cell;MDA MB 231;Measurement;Medical;Methodology;Methods;microRNA biomarkers;MicroRNAs;Modeling;Nature;Nerve Degeneration;Neuroblastoma;Neurons;novel;Parkinson Disease;Pathologic;PC12 Cells;PC3 cell line;Performance;Pharmacotherapy;Phase;Physiological;Polyadenylation;Polymerase;Polymerase Chain Reaction;Preparation;Principal Investigator;Procedures;Process;programs;Prostate;Recovery;Reporting;Research;Research Activity;Reverse Transcription;RNA;Sampling;Serum;Signal Transduction;Single-Stranded DNA;skills;Solid;Specimen;student participation;Students;Surface;tandem mass spectrometry;Techniques;Testing;two-dimensional;Uncertainty;Universities;Urine;Validation;Work

PROJECT_TITLE: PCR-free  UPLC-MS/MS based quantitative assay of microRNAs


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Food Allergies;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Atopic disease is a major public health problem affecting up to 20% of the world’s population, with a substantial psychosocial and economic burden for children and families and rising prevalence in recent decades; child atopic risk has been associated with maternal antenatal anxiety, yet we know little about the biological mechanisms that may underlie this association. This study will examine both maternal and child immune activity from pregnancy through the first year (through stimulated immune cells, the cytokines they produce, and gene expression in cord blood), and will determine dyadic immune activity and associations with the child’s atopic risk, accounting for elements of anxious parenting in the postnatal environment. These findings will shed light on the biological pathways contributing to risk for atopyin children, and may lead to novel interventions to ameliorate both maternal symptomatology and child risk.

PI_NAMEs: OSBORNE, LAUREN M (contact);VOEGTLINE, KRISTIN M

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: Accounting;adaptive immunity;Affect;Age Months;Allergens;Allergic;Allergic Reaction;antenatal;Anxiety;anxiety symptoms;anxious;Asthma;Atopic Dermatitis;atopy;Biological;Biological Markers;Birth;Bronchiolitis;Cells;Child;Child Mortality;Child Rearing;cigarette smoking;Clinical;clinical risk;clinically significant;cytokine;Data;Development;Diagnosis;Dietary Factors;Disease;DNA Methylation;early childhood;Economic Burden;Elements;Environment;Environmental Exposure;epigenetic marker;Family;feeding;fetal;Financial Hardship;Food;Food Hypersensitivity;Frequencies;Future;Gene Expression;Genes;Genetic Risk;Goals;Hydrocortisone;Hypersensitivity;Immune;immune activation;immune function;Immune system;Immunologic Markers;Immunologic Stimulation;Immunologics;in utero;infancy;Infant;Inflammatory;innovation;Interleukin-1 beta;Interleukin-6;Intervention;Link;Longitudinal, observational study;mast cell;maternal anxiety;Measures;Mediating;Methylation;Mitogen-Activated Protein Kinases;monocyte;Morbidity - disease rate;Mother-Child Relations;Mothers;Natural Immunity;Neonatal;Newborn Infant;novel;obstetrical complication;Pathway interactions;Perinatal;Population;postnatal;Pregnancy;Pregnant Women;prenatal exposure;Prevalence;Production;prospective;psychologic;psychosocial;Public Health;Quality of life;Questionnaires;Reaction;recruit;reduce symptoms;Regulatory T-Lymphocyte;Reporting;Risk;Risk Factors;Second Pregnancy Trimester;Signal Transduction;symptomatology;Th1 Cells;Third Pregnancy Trimester;TNF gene;Umbilical Cord Blood;Woman;Work

PROJECT_TITLE: Antenatal Anxiety and Dyadic Immune Risk(ADIR Study)

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunization

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Narrative This project develops and tests a novel platform strategy that has been designed to reduce the undesired toxicity of antibody-drug conjugates (ADCs). Nine ADCs are currently approved for use in treating cancer in the United States, and more than 100 ADC agents are in current clinical testing. The strategy introduced in this proposal is expected to increase the tolerability of ADC therapy, allowing increased safety and efficacy in the treatment of cancer; if successful, the approach may be applied broadly, potentially providing benefit to large populations of cancer patients.

PI_NAMEs: BALTHASAR, JOSEPH P (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Address;Affinity;anti-cancer;Antibodies;Antibody-drug conjugates;Antineoplastic Agents;Binding;Bystander Effect;Camptothecin;cancer cell;Cancer Patient;cancer therapy;Catabolism;Cell Culture Techniques;Cell membrane;Cells;Cessation of life;Charge;Circulation;clinical application;clinical investigation;Clinical Trials;Conjugating Agent;cytotoxicity;design;Development;Diffuse;Diffusion;Dose;Drug Kinetics;efficacy evaluation;Engineering;Enhancers;Evaluation;experimental study;extracellular;Extracellular Fluid;Failure;Filtration;Gemtuzumab Ozogamicin;Hydrolysis;Immunocompetent;Immunoglobulin Fragments;Immunoglobulin G;improved;In Vitro;in vivo evaluation;Kidney;Kinetics;Lead;Left;Malignant Breast Neoplasm;Malignant Neoplasms;Marketing;mathematical model;Membrane Proteins;Metabolic Clearance Rate;Modality;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;nanobodies;novel;Pathway interactions;Patients;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Population;premature;prevent;pyrrolobenzodiazepine;receptor mediated endocytosis;Refractory;Regimen;research clinical testing;Resistance;Safety;Series;Site;Structure;targeted delivery;targeted treatment;Testing;Therapeutic;Tissues;Toxic effect;Toxicokinetics;Toxin;Translations;Trastuzumab;tumor;Tumor Antigens;tumor eradication;tumor specificity;United States;uptake;Work

PROJECT_TITLE: Enhancement of ADC selectivity by inverse targeting: Mechanistic studies and optimization

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Mental Health;Suicide

ORG_CITY: PROVIDENCE

ORG_DEPT: PSYCHIATRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Suicidal behavior is a major public health problem in the United States with rates deaths by suicide and suicide attempts increasing over the past 10 years. While there have been multiple calls for increased research into the causes and interventions to reduce suicidal behavior, effective research has been limited by the small number of researchers trained to conduct high quality suicide research. This application proposes a post-doctoral training program that will train young investigators to conduct cutting edge research regarding suicidal behavior.

PI_NAMEs: MILLER, IVAN W.;WEINSTOCK, LAUREN M (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: post-doctoral training;Research;Suicide

PROJECT_TITLE: Postdoctoral Training in Suicide Research


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Mental Health;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE  The overall objective of this proposal is to test, using a cluster-randomized RCT, the impact and sustainability of a health system leadership alignment strategy to achieve successful integration of an evidence-based, task-shared mental health treatment model into general medical care in Malawi. Leadership alignment is an essential ingredient for successful mental health integration but has received extremely limited attention in low and middle income countries. This project will make a major contribution to our understanding of the role of leadership alignment in advancing evidence-based mental health integration.

PI_NAMEs: KULISEWA, KAZIONE ;PENCE, BRIAN W (contact)

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: Address;Adoption;arm;Attention;Attitude;Caring;Charge;Climate;Clinic;clinical care;Cluster randomized trial;cost effectiveness;Country;Data;Disease;effective intervention;Effectiveness;effectiveness outcome;empowerment;Ensure;evidence base;Evidence based treatment;Feedback;Funding;Goals;Grant;health care settings;health science research;Health Services Research;Health system;HIV;implementation efforts;implementation science;implementation strategy;Income;Industrial Psychology;innovation;Leadership;leadership development;low and middle-income countries;low income country;Malawi;Manuscripts;Medical;member;Mental Depression;Mental Health;Mental Health Services;Modeling;Mood Disorders;National Institute of Mental Health;Norway;Organizational Change;organizational climate;Outcome Measure;Patients;Play;Policies;Policy Maker;Process;programs;projectin;Provider;Randomized;randomized trial;Research;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Resource-limited setting;Rewards;Role;Structure;success;Supervision;symposium;Testing;tool;Work;Writing

PROJECT_TITLE: Aligning facility leadership and climate to advance mental health services integration in Malawi


NIH_SPENDING_CATS: Complementary and Integrative Health;Dietary Supplements;Eye Disease and Disorders of Vision;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: We will examine if DHA/AA controls neurovascular development in phase 1 ROP by improving mitochondrial and peroxisomal fatty acid oxidation; little work has been done in this area. We have preliminarily found a large beneficial effect of DHA/AA vs. AA only and DHA only on promoting normal retinal vascular formation which is suppressed during hyperglycemia- induced early changes in phase I ROP, leading to later proliferative disease. DHA/AA supplements may prevent ROP.

PI_NAMEs: FU, ZHONGJIE ;SMITH, LOIS  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Address;adiponectin;Affect;angiogenesis;Arachidonic Acids;Area;Attenuated;Blood;Blood Vessels;Carbon;cell type;Cells;Circulation;Clinical;Data;Development;Diet;dietary;dietary control;Disease;Docosahexaenoic acid supplement;Docosahexaenoic acid supplementation;Docosahexaenoic Acids;Energy Metabolism;extreme prematurity;fatty acid oxidation;Fatty Acids;Fibroblast Growth Factor;Glucose;Glycolysis;Grant;Growth;Growth Factor;Hyperglycemia;Hyperglycemic Mice;improved;in utero;Infant;Intervention;Knowledge;lipidomics;Lipids;Metabolic;Metabolism;metabolomics;Mitochondria;mitochondrial metabolism;Modeling;Morphology;Mus;Mutant Strains Mice;neovascular;neovascularization;Neuronal Dysfunction;neuronal metabolism;Neurons;Neurophysiology - biologic function;neurovascular;novel;Oral;oral supplementation;oxidation;Oxygen;Pathway interactions;Phase;Photoreceptors;Physiological;Physiology;Pilot Projects;Placenta;Platelet-Derived Growth Factor;Polyunsaturated Fatty Acids;postnatal;Premature Birth;Premature Infant;preservation;prevent;Recycling;Reporting;Respiration;response;Retina;retina blood vessel structure;Retinal Diseases;retinal neuron;Retinopathy of Prematurity;Risk Factors;Role;Serum;Signal Transduction;Structure;Testing;transcriptome sequencing;transcriptomics;Vascular Endothelial Growth Factors;Vascularization;Work

PROJECT_TITLE: Dietary control of angiogenesis in retinopathy models

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Women's Health Research

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The Penn WRHR Center will encourage and foster the development of academic obstetrician gynecologists in order to contribute to the improvement of the health of women and their children.

PI_NAMEs: HOWELL, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, STEVEN

PROJECT_TERMS: Academic support;Back;Basic Science;Bioinformatics;Biomedical Research;Biometry;career;career development;Clinical Research;Department chair;design;Development;Discipline of obstetrics;editorial;Education;Educational workshop;Enrollment;Epidemiology;experience;Faculty;Fostering;Foundations;Funding;Goals;Grant;Growth;Gynecologist;Gynecology;Infrastructure;innovation;Institution;Investigation;Knowledge;Leadership;medical schools;Medicine;member;Mentors;next generation;Philosophy;Physicians;Positioning Attribute;Productivity;Professional Organizations;Program Development;programs;recruit;Reproduction;Reproductive Biology;Research;research and development;research facility;Research Personnel;Scholarship;skills;Study Section;supportive environment;Training;translational medicine;Translational Research;United States National Institutes of Health;Women's Health;women's reproductive health

PROJECT_TITLE: The Penn Center for Career Development in Women's Health Research


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: SEATTLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: MACCOSS, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Area;Basic Science;Binding;Biological Assay;biomedical scientist;Cells;Collection;Communities;Computer software;Computer Systems;computerized data processing;Data;Data Analyses;data integration;data reuse;Data Scientist;Development;Dictionary;Disease;Documentation;Ecosystem;Educational workshop;Ensure;experimental study;Genes;Grant;Growth;improved;Infrastructure;innovation;instrument;knowledgebase;lipidomics;Maintenance;mass spectrometer;Mass Spectrum Analysis;meetings;metabolomics;Metadata;method development;Methods;Molecular;Monitor;Ontology;Peptides;Performance;Persons;Phenotype;Process;Production;Proteomics;Publishing;Quality Control;Reaction;Reading;Research;Research Personnel;Resource Sharing;Resources;small molecule;software development;Software Tools;Stress Tests;support tools;synergism;System;tandem mass spectrometry;Testing;Time;tool;Training;Translational Research;Vendor;web site;webinar;Work;Writing

PROJECT_TITLE: Seattle Quant: A Resource for the Skyline Software Ecosystem


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: N. gonorrhoeae, the infectious pathogen that causes gonorrhea, is the second most common reportable disease in the US, and its incidence and resistance to antibiotics are rising at an alarming rate. These clinical outcomes are determined by multi-protein assemblies that mediate neisserial growth, human cell adhesion, host invasion and clinical persistence. Using innovative functional proteomics, computational, and biological methods, our project aims to generate a systems-wide understanding of key protein macromolecules involved in gonococcal pathobiology, revealing new targets to combat gonorrheal infections.

PI_NAMEs: EMILI, ANDREW  (contact);GRAY-OWEN, SCOTT D

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Address;Animal Model;Antibiotic Resistance;Antibiotics;Architecture;Automobile Driving;Awareness;Bacteria;Biological;Biological Assay;Biology;Biomedical Research;Cell Adhesion;Cells;chronic infection;Clinical;clinically relevant;combat;commensal bacteria;Communicable Diseases;Communities;comparative;Comparative Genomic Analysis;comparative genomics;Computer Models;Development;Disease;drug development;drug discovery;Drug resistance;Environment;Escherichia coli;Etiology;experimental study;female reproductive tract;fitness;follow-up;Foundations;frailty;Functional dependence;Future;gene complementation;Gene Expression Profiling;Generations;Genetic Screening;Genitalia;Genome;Genomic approach;Genomics;Goals;Gonorrhea;Grant;Growth;Health;Host resistance;Human;human pathogen;humanized mouse;Immune Evasion;improved;In Vitro;in vivo;Incidence;Infection;innovation;insight;Interdisciplinary Study;Intervention;Invaded;Investigation;Knowledge;Knowledge acquisition;Label;Life;macromolecule;Male Genital Organs;Maps;Mass Spectrum Analysis;Mediating;Metabolic;Metabolism;Methods;Microbe;microbiome;Modeling;Molecular;Morbidity - disease rate;mouse model;Mucous Membrane;Mutagenesis;Neisseria gonorrhoeae;Nutrient;Outcome;pathogen;Pathogenesis;Pathologic;Pathway Analysis;pharmacologic;Phenotype;Physiological;Physiology;Population;Process;protein complex;protein protein interaction;Proteins;Proteome;Proteomics;Recording of previous events;research study;Resistance;Resistance to infection;resistant strain;Resources;Role;Sexually Transmitted Agents;Sexually Transmitted Diseases;Stress;Superbug;System;Systems Biology;Technology;Therapeutic;Therapeutic Intervention;Transgenic Mice;trend;Validation;validation studies;Variant;Work

PROJECT_TITLE: Mapping Protein Interaction Networks Essential for Gonococcal Pathogenesis

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunotherapy;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE The purpose of this proposal is to test a new cellular therapy for chronic norovirus infection in patients undergoing hematopoietic stem cell transplant and in patients with primary immunodeficiency. By using banked T cells targeting norovirus, we hope to resolve norovirus infections, and also better understand how T cells confer protection to norovirus, which may help future cellular therapy and vaccine studies.

PI_NAMEs: KELLER, MICHAEL DANIEL (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: 16S ribosomal RNA sequencing;Adenoviruses;Adoptive Transfer;Alleles;anti-viral efficacy;Anti-viral Response;Anti-viral Therapy;Antigens;Biological Assay;Blood;Blood donor;Capsid Proteins;CD8B1 gene;Cell Therapy;Cells;Chronic;Chronic diarrhea;chronic infection;Clinical;Collaborations;Complication;congenital immunodeficiency;Cytomegalovirus;cytotoxicity;Data;Development;Diarrhea;Disease;Disease Outbreaks;disorder control;Dose;effective therapy;Enteral;Epidemic;Epitope Mapping;Epitopes;fecal microbiome;Feces;Flow Cytometry;Future;Gastroenteritis;gastrointestinal symptom;Genetic;Genotype;Goals;Hematopoietic Stem Cell Transplantation;Hepatotoxicity;Hospitalization;Human;Human Herpesvirus 4;Immune;Immunity;Immunocompromised Host;Immunologic Deficiency Syndromes;improved;in silico;in vivo;Individual;Infection;Infusion procedures;insight;Interferon Type II;Knock-out;Life;Malabsorption Syndromes;Malignant - descriptor;Malignant Neoplasms;Modeling;Monitor;Morbidity - disease rate;Mus;National Institute of Allergy and Infectious Disease;next generation sequencing;Non-Malignant;Norovirus;novel;novel therapeutics;Patient Transfer;Patients;Peptide Hydrolases;Peptides;perforin;Phase;phase I trial;prediction algorithm;Quality of life;Reporting;response;RNA Viruses;Safety;safety and feasibility;safety study;seropositive;Sorting;Splenocyte;Spottings;Surveys;T cell response;T cell therapy;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;Therapeutic;Therapy trial;tool;Toxic effect;Transplant Recipients;TRB@ gene cluster;treatment choice;United States National Institutes of Health;Vaccinated;vaccine development;vaccine trial;Vaccines;Variant;Villous Atrophy;Viral;Viral Genome;Viral Physiology;Virion;Virus;Virus Diseases;Viviparous-1 protein;wasting

PROJECT_TITLE: Adoptive T Lymphocyte Administration for Chronic Norovirus Treatment Following Hematopoietic Stem Cell Transplantation

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


ORG_CITY: HOUSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE It has become increasingly clear that there is a need to improve the current version of oncolytic virotherapy for a better clinical benefit. We plan to develop a strategic three-pronged immune-virotherapy to overcome the two major hurdles hindering cancer virotherapy - the relatively weak therapeutic activity and lack of means for effective systemic delivery, and the developed strategy can be translated into the clinic in the near future.

PI_NAMEs: ZHANG, SHAUN XIAOLIU (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Activated Natural Killer Cell;antigen-specific T cells;antitumor effect;arm;cancer immunotherapy;CD8 receptor;CD8-Positive T-Lymphocytes;cell killing;Cell Maturation;chemokine;Clinic;Clinical;clinical application;clinical practice;Colon Carcinoma;combinatorial;Cross Presentation;Data;Dendritic Cells;design;Development;Disease;draining lymph node;effective therapy;Effectiveness;Ensure;Epidermal Growth Factor Receptor;ERBB2 gene;Event;experimental study;FCGR3B gene;Future;Herpesvirus 1;Homing;Human Herpesvirus 2;Immune;Immune system;Immunity;improved;In Vitro;in vivo;individual patient;Infiltration;Injections;Interleukin-2;joint destruction;Macrophage;Malignant neoplasm of lung;Malignant Neoplasms;Measurable;Mediating;Melanoma;migration;Natural Killer Cells;neoantigens;neoplastic cell;neutralizing antibody;Nodule;novel;novel strategies;oncolysis;Oncolytic;oncolytic virotherapy;Oncolytic viruses;Outcome;Patients;Procedures;receptor;Receptor Activation;Route;Series;Simplexvirus;Site;Solid Neoplasm;System;systemic barrier;Systemic disease;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;Translating;Treatment Efficacy;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Virotherapy;Virus;XCL1 gene

PROJECT_TITLE: Actively engaging NK cells during virotherapy to induce neoantigen-specific antitumor immunity

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Parkinson’s disease (PD) affects more than one million Americans, and there is no therapy that slows the progression of any feature of this age-related, relentlessly progressive neurodegenerative disease. There is now class II evidence that deep brain stimulation (DBS) slows the progression of rest tremor when applied in early-stage Parkinson’s disease. Before proceeding to a multicenter, randomized clinical trial, this study will quickly fill gaps in knowledge needed incorporate neuroimaging and wearable biosensors into an outpatient therapeutic washout in order to objectively evaluate the underlying progression of Parkinson’s disease.

PI_NAMEs: HACKER, MALLORY L. (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acceleration;Activities of Daily Living;Address;Affect;age related;age related neurodegeneration;aged;Aging;aging population;American;Animal Model;Area;Biochemical Pathway;Bradykinesia;Brain scan;Care given by nurses;career;career development;Clinical;Clinical assessments;Clinical Trials;Communities;cost effective;Data;Deep Brain Stimulation;Disease;Disease Progression;Distress;Dyskinetic syndrome;Early treatment;electron tomography;Enrollment;Environment;experience;FDA approved;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Funding;Future;Goals;Healthcare;Idiopathic Parkinson Disease;improved;Inpatients;Intervention;Investigation;Knowledge;Measurement;Measures;Medical;Mentorship;Metabolic;Methods;Modification;Motor;motor symptom;multidisciplinary;Nervous System Disorder;neural network;Neurodegenerative Disorders;neuroimaging;Neurons;novel therapeutics;older adult;Outpatients;Parkinson Disease;patient population;Patients;Pharmaceutical Preparations;phase III trial;pilot trial;Placebo Effect;Positron;Positron-Emission Tomography;preclinical study;preservation;prospective test;Protocols documentation;Quality of life;Randomized;randomized, clinical trials;Research;Rest Tremor;Risk;Safety;Scanning;Scientist;Severities;Severity of illness;side effect;Single-Blind Study;standard care;Symptoms;Testing;Therapeutic;Training;Tremor;Uncertainty;Universities;wearable device;wearable sensor technology

PROJECT_TITLE: Feasibility of Objective Measures and Outpatient Washout in Disease-Modifying Trials for Parkinson's Disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Narrative Developmental biology is the study of how organisms self organize to produce mature life forms. It has always been an important discipline within Biology, and with the growing interest in understanding pediatric disorders and the introduction of stem cells for medical therapies, it is now more timely than ever. This broad based training program is designed to train the next generation of developmental biologists who will advance our understanding of normal developmental processes and thereby make it possible to harness the promise of stem cell therapy.

PI_NAMEs: GRANATO, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Developmental Biology;Training

PROJECT_TITLE: Graduate Training in Developmental Biology


ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE: OVERALL The Prevention, Preparedness, and Response (P2R) Consortium is relevant to public health because it will deliver practical health and safety training to workers and communities. This consortium focuses on teaching workers to recognize and mitigate hazards. It places special emphasis on training workers to protect themselves and their families and build their community’s capacity to respond to environmental and work-related threats.

PI_NAMEs: RIOS, JANELLE  (contact)

PROGRAM_OFFICER_NAME: PERSAUD, ERIC

PROJECT_TERMS: Address;Adult;Biological;Chemicals;climate change;Communities;community building;Consult;Country;Dedications;design;Development;Disasters;Discipline;Ebola virus;Educational process of instructing;Emerging Communicable Diseases;Ensure;Environment;Environmental Health;Event;evidence base;experience;Explosion;Exposure to;extreme weather;Family;Fatal injury;Fire - disasters;Floods;Future;Geography;Goals;Government Officials;hazard;hazardous materials disaster;Hazardous Substances;Hazardous Waste;Health;health literacy;Health Promotion;Health protection;high risk;Hour;Hurricane;improved;Industrialization;Industry;Injury;Knowledge;learning strategy;Lightning;Morbidity - disease rate;mortality;National Institute of Environmental Health Sciences;neglect;Occupational Health;Outcome;Personal Satisfaction;Persons;Population;Predisposition;prevent;Prevention;Privatization;Problem Solving;Professional Organizations;programs;Public Health;Radiology Specialty;Readiness;remediation;Reporting;resilience;Resources;response;Safety;skills;statistics;Strategic Planning;success;Target Populations;Teaching Method;Techniques;Training;Training Programs;underserved community;United States;United States Dept. of Health and Human Services;United States Public Health Service;Vision;volunteer;vulnerable community;Wildfire;Work;Workplace


NIH_SPENDING_CATS: Infectious Diseases;Prevention

PROJECT_TERMS: Amendment;Area;Arkansas;Attention;Authorization documentation;Biological;Categories;Chemicals;Collaborations;Colorado;Communicable Diseases;Communication;Communities;Contracts;Country;Dedications;Disasters;Discipline;Emotional;empowerment;Ensure;evidence base;Excision;experience;first responder;Goals;Government;hazard;hazardous materials disaster;Hazardous Substances;Hazardous Waste;Health;Health protection;Healthcare;high risk;Hour;Illinois;improved;Indiana;Industry;Infection prevention;Louisiana;manufacture;Michigan;Mining;Minnesota;Montana;National Institute of Environmental Health Sciences;New Mexico;new technology;Nonprofit Organizations;North Dakota;Nuclear;Occupations;Ohio;Oklahoma;operation;Opioid;Personal Satisfaction;Population;Prevention;Prevention program;Process;programs;Public Health;Readiness;resilience;Resources;response;Risk;Safety;Services;skills;South Dakota;Strategic Planning;Substance abuse problem;success;Superfund;Techniques;Texas;Training;Training Programs;Transportation;United States Dept. of Health and Human Services;United States Public Health Service;Universities;Utah;Vision;volunteer;vulnerable community;Waste Management;wasting;Wisconsin;Work;Workplace;Wyoming

PROJECT_TITLE: Hazardous Waste Worker Training Program (HWWTP)


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Emergency Care;Prevention

PROJECT_TERMS: Area;Arkansas;Biological;Caring;Cessation of life;Chemicals;climate change;climate impact;Colorado;Communities;community building;Country;Dedications;Disasters;Discipline;Emergency Medical Technicians;Environmental Health;Event;evidence base;experience;extreme weather;Fire - disasters;first responder;Floods;Gases;Goals;Government Officials;hazard;hazardous materials disaster;Hazardous Substances;Hazardous Waste;Health;Health protection;Healthcare;high risk;Hour;Human;Human Resources;Illinois;improved;Indiana;Individual;Industrialization;Industry;Infrastructure;Law Enforcement;Lightning;Louisiana;Michigan;Minnesota;Montana;Natural Disasters;New Mexico;North Dakota;Ohio;Oils;Oklahoma;Personal Satisfaction;Population;Prevention;Prevention program;programs;Public Health;Radiology Specialty;Readiness;Resources;response;Safety;sea level rise;skills;Societies;South Dakota;success;Techniques;Terrorism;Texas;Time;Training;training opportunity;Training Programs;Translating;United States Dept. of Health and Human Services;United States Public Health Service;Utah;Vision;volunteer;vulnerable community;wasting;Wisconsin;Work;Wyoming

PROJECT_TITLE: Hazmat Disaster Preparedness Training Program (HDPTP)


NIH_SPENDING_CATS: Genetics;Hematology;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Precisely controlled migration of lateral plate mesoderm cells after gastrulation contributes to proper hematopoietic cell fate specification and lineage survival. The ultimate goal of this project is to understand how syndromic blood anomalies arise from defective LPM patterning. As proxy, we seek to understand the mechanisms causing Thrombocytopenia with absent radius (TAR) syndrome, a rare, complex congenital blood anomaly, that manifests with defects in blood (thrombocytes), forelimb, and heart, kidney lineages, which are all seemingly unrelated phenotypes, but are specified cell lineages of the LPM.

PI_NAMEs: BURGER, ALEXA  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: 1q21;Affect;Alleles;Attenuated;attenuation;autosome;Binding;Biological Models;Birth;Blood;Blood Platelets;Cardiovascular system;cell fate specification;Cell Lineage;Cells;Chromosomes;cohort;comorbidity;Complex;Congenital Abnormality;CRISPR/Cas technology;crosslink;Curiosities;Data;Defect;Development;Disease;Embryo;Event;Exons;experimental study;Forelimb;Frequencies;gastrulation;Genes;Genetic;Genetic Models;Goals;Heart;Hematology;Hematopoietic;hematopoietic stem cell formation;Hematopoietic stem cells;Heterozygote;Human;Image;Immunoprecipitation;Impairment;in vivo;Individual;insight;Joints;Kidney;Lateral;Limb structure;Link;Location;Mediating;Mesoderm;Mesoderm Cell;Messenger RNA;microdeletion;migration;Modeling;Molecular;mRNA Transcript Degradation;mutant;Mutation;novel;Nuclear Export;Organ;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Phenotype;planar cell polarity;protein expression;Protocols documentation;Proxy;Radial;radius bone structure;Recommendation;recruit;Regulation;Reporter;RNA;RNA Decay;RNA Splicing;RNA-Binding Proteins;Role;Series;Signal Transduction;Single Nucleotide Polymorphism;Smooth Muscle;Specific qualifier value;stem cell migration;stem cells;Syndrome;Testing;Text;Thrombocytopenia;Tissues;tool;transcriptome;transcriptome sequencing;Transgenes;Transgenic Organisms;Translations;Untranslated RNA;vertebrate embryos;WNT Signaling Pathway;Work;Zebrafish

PROJECT_TITLE: Developmental causes of syndromic Thrombocytopenia and co-morbidities

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Neurosciences;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Despite the significant public health burden associated with out-of-hospital cardiac arrest (OHCA), our understanding of the trajectory of long-term recovery and key contributors to survivorship and reaching a `new normal' after OHCA is limited. POST- ICECAP, an ancillary study to an ongoing NIH funded trial, will be the first, and certainly the largest study to describe the recovery in the most diverse group of OHCA survivors. It will comprehensively assess the relationship between the initial severity of the OHCA, critical care interventions, inpatient rehabilitation, and social determinants of health with improvement or deterioration in dependence on others for everyday activities, cognition, and quality of life in the first 12 months after survival from OHCA.

PI_NAMEs: AGARWAL, SACHIN  (contact);CALLAWAY, CLIFTON W.

PROGRAM_OFFICER_NAME: SCOTT, GRETCHEN CARLYLE

PROJECT_TERMS: Acute;acute care;Ancillary Study;Back;Black race;Brain;Caring;Characteristics;Clinical;clinical practice;Cognition;Cognitive;Cognitive deficits;cognitive recovery;cohort;Coma;comorbidity;Consciousness Disorders;Continuity of Patient Care;Coronary Angiography;Critical Care;Data;Dependence;Deterioration;disability;Discrimination;Disparity;Eligibility Determination;Emergency Care;Employment;Enrollment;Environmental Risk Factor;Equity;ethnic disparity;ethnic diversity;Ethnic Origin;Event;experience;Family;follow-up;functional outcomes;Funding;Guidelines;Health;health care availability;health related quality of life;Heart Arrest;Hispanic;Home;hospital care;Hospitalization;Hospitals;Hour;hypoxic ischemic injury;Impaired cognition;Impairment;improved;indexing;Individual;individual patient;individual variation;Inpatients;Insurance;Intervention;Knowledge;Latinx;Length of Stay;long term recovery;National Heart, Lung, and Blood Institute;National Institute of Neurological Disorders and Stroke;natural hypothermia;Neurologic;Not Hispanic or Latino;out-of-hospital cardiac arrest;Outcome;Outcome Assessment;Outpatients;Parents;Patient Self-Report;patient variability;Patients;Pattern;performance based measurement;Persons;Physiological;Pilot Projects;preservation;primary outcome;psychological distress;Public Health;Quality of life;Race;racial disparity;racial diversity;racism;Randomized;Recovery;Recovery of Function;recruit;Rehabilitation therapy;Reporting;Resuscitation;Role;Science;secondary outcome;Severities;Severity of illness;Site;Skilled Nursing Facilities;social factors;social health determinants;Socioeconomic Factors;Survivors;survivorship;Telephone;Testing;treatment as usual;United States National Institutes of Health;Videoconferencing;Visit;Work

PROJECT_TITLE: Patterns of Survivors' Recovery Trajectories in the ICECAP Trial (POST-ICECAP)

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE We propose to investigate the mechanisms of action of the NSD2 methyltransferase in mammalian cells, including elucidating its biochemical and functional activity and by testing the first-in-class NSD2 inhibitor in treatment of lung cancer cells in culture and in vivo.

PI_NAMEs: GOZANI, OR P.;MAZUR, PAWEL K. (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Acceleration;Adverse event;Biochemical;Cancer Etiology;Cancer Model;Cells;Cessation of life;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical;clinical prognosis;clinically actionable;combat;Combined Modality Therapy;CRISPR interference;Disease;DNA methylation profiling;Dose;Drug resistance;Drug Targeting;Drug toxicity;efficacy testing;Enzymes;Epigenetic Process;Epitopes;Evolution;experimental study;Future;Gene Expression;Genetic Models;Goals;Heterogeneity;Histologic;Histones;human model;immune checkpoint blockade;Immunotherapy;improved;in vivo;inhibitor;insight;interest;KRAS2 gene;KRASG12D;Lung Adenocarcinoma;lung cancer cell;Lysine;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Mammalian Cell;MAP Kinase Gene;MAP2K1 gene;Measures;Medicine;Methylation;Methyltransferase;Modeling;Molecular;mortality;mouse model;multiple omics;Mus;mutant;Mutation;nanomolar;Neoplasm Metastasis;neoplastic cell;novel;Oncogenic;Outcome;Output;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;pre-clinical;Pre-Clinical Model;Prognosis;programs;Proteins;Regulation;Reporting;Resistance development;Resolution;Role;Signal Transduction;small molecule inhibitor;standard of care;System;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;transcriptomic profiling;translational study;Treatment Efficacy;Treatment outcome;tumor;tumor growth;tumor heterogeneity;tumor progression;United States;Up-Regulation;Work;Xenograft procedure

PROJECT_TITLE: Therapeutic Targeting of NSD2 in Lung Adenocarcinoma


ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The prime objective of our National K12 “Diabetes-Docs: Physician-Scientist Career Development Program” (DiabDocs) is to train and foster the development of diverse physician-scientists for productive and impactful diabetes research careers with a specific focus on type 1 diabetes (T1D). Our K12 program is designed to provide: 1) a mentored research experience, 2) research project support, and 3) career development training, including directed attention to diversity, equity and inclusion. We are confident that we will attract the highest caliber of applicants and mentor them toward impactful careers in academic medicine as skilled physician-scientist leaders.

PI_NAMEs: DIMEGLIO, LINDA A;MAAHS, DAVID MATTHEW (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Adult;Basic Science;bench to bedside;Budgets;Caliber;career;career development;catalyst;Clinical;cohesion;cohort;design;Diabetes Mellitus;directed attention;Education;Educational Curriculum;Effectiveness;Endocrinology;Ensure;equity, diversity, and inclusion;evidence base;experience;Faculty;Funding;Geography;Goals;Health Services Research;Individual;Institution;Insulin-Dependent Diabetes Mellitus;interest;Investigation;Leadership;Medical Students;Medicine;Mentored Clinical Scientist Development Program;mentoring community;Mentors;multidisciplinary;next generation;Pathway interactions;patient oriented;Physicians;Positioning Attribute;Program Development;programs;Recruitment Activity;Research;Research Personnel;Research Support;Resources;Scholars Program;Science;Scientist;skills;Structure;Training;Underrepresented Populations

PROJECT_TITLE: Diabetes-Docs: Physician-Scientist Career Development Program (DiabDocs)

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK(M1)-1-B]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Disability Research;Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: The proposed research seeks to systematically identify plasticity mechanisms that lead to enhanced visual ability. The work will provide new insights on neural mechanisms of visual augmentation, and may suggest new treatments for visual disabilities such as amblyopia.

PI_NAMEs: FONG, MING-FAI  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Acute;Address;Affect;Amblyopia;Animal Model;Animals;area striata;Automobile Driving;Bilateral;Blindness;Brain;Brain Diseases;Brain Injuries;cell type;Cells;Chemosensitization;Clinical;Data;design;Development;disability;Disparity;early childhood;Electrophysiology (science);experience;Experimental Designs;experimental study;Eye;Feedback;Felis catus;Functional disorder;Future;Goals;Hour;Human;in vivo calcium imaging;infancy;Injury;insight;Intervention;Knowledge;Life;Long-Term Potentiation;Measures;Membrane;Mental Depression;Mentors;Modality;Monitor;monocular deprivation;Mus;Nature;nervous system development;Nervous System Disorder;neural;neural circuit;Neurologic;neuromechanism;Neuronal Plasticity;Neurosciences Research;Ocular Dominance;optogenetics;Outcome;Play;postnatal;Process;Property;Public Health;Quality of life;Recovery;Rejuvenation;Research;response;Retina;Role;Sensory;sensory cortex;Sensory Process;Slice;statistics;Synapses;Synaptic plasticity;System;Technology;Testing;Thalamic structure;Time;Translating;treatment strategy;Update;Vision;Visual;Visual Cortex;Visual disability;Visual impairment;Work

PROJECT_TITLE: Controlling synaptic and intrinsic plasticity underlying visual cortical enhancement

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Prostate Cancer;Urologic Diseases

ORG_DEPT: UROLOGY

PHR: PROJECT NARRATIVE The proposed studies will define novel mechanisms underlying aggressive features of human prostate cancer and reveal novel stromal cell-mediated regulatory mechanisms in tumor microenvironment that can be therapeutically exploited for the treatment of aggressive prostate cancer.

PI_NAMEs: XIN, LI  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Anatomy;anti-CTLA4;anti-PD-1;Cancer Etiology;cancer initiation;Candidate Disease Gene;candidate identification;Cessation of life;chemokine;ChIP-seq;clinically significant;CRISPR/Cas technology;cytokine;Data;Disease Progression;Down-Regulation;Early Intervention;Frequencies;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Genetically Engineered Mouse;genome-wide;Gleason Grade for Prostate Cancer;Goals;Growth;Human;immune checkpoint blockade;Immunocompetent;in vivo;Indolent;Knock-out;Laboratories;Lead;Left;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;men;Modeling;Molecular;mouse model;Mus;Mutagenesis;Myeloid-derived suppressor cells;Nature;Neuroendocrine Tumors;Newly Diagnosed;NF-kappa B;novel;overexpression;overtreatment;Pathologic;Patients;Peripheral;Play;Prognostic Marker;Prostate;Prostate Adenocarcinoma;prostate cancer model;prostate cancer progression;recruit;Recurrence;Role;screening;Signal Transduction;Stromal Cells;Testing;Therapeutic;Therapeutic Intervention;Tissues;transcription factor;Transcriptional Activation;transcriptome sequencing;tumor;tumor initiation;tumor microenvironment;tumor progression;tumor xenograft;United States;Up-Regulation;Xenograft procedure

PROJECT_TITLE: Stromal Foxf2 suppresses prostate cancer progression

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Cancer;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: In the aging US population, there is an increasing incidence of bone marrow disorders such as Myelodysplastic Syndromes (MDS). Since these diseases often progress to more aggressive therapy-resistant leukemias, they place a significant burden on the healthcare system. Our work aimed at defining the functional role of bone marrow endothelial cell signals in supporting MDS growth and progression may open up new therapeutic avenues to halt the progression of these bone marrow failure disorders.

PI_NAMEs: BAJAJ, JEEVISHA  (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;Affect;aggressive therapy;Aging;aging population;angiogenesis;Angiogenic Factor;Biological Assay;Blood Vessels;Bone Marrow;Bone marrow biopsy;Bone Marrow Diseases;Bone marrow failure;burden of illness;cell injury;Cell Physiology;Cell Separation;Cell Surface Receptors;Cells;Cellular Structures;Chemoresistance;chemotherapy;Coculture Techniques;Data;density;design;Diagnosis;Differentiation and Growth;Disease;Disease Progression;Dysmyelopoietic Syndromes;Elderly;Endothelial Cells;Endothelium;Gene Expression;Gene Expression Profile;Growth;Healthcare Systems;Hematopoietic;hematopoietic stem cell differentiation;Hematopoietic stem cells;in vivo imaging;Incidence;leukemia;Ligands;Maps;Modeling;Molecular;mouse model;Mus;Myelogenous;novel therapeutic intervention;novel therapeutics;Pathway interactions;Patients;Population;Proliferating;Role;self-renewal;Signal Transduction;single-cell RNA sequencing;Solid Neoplasm;spatiotemporal;Syndrome;System;Techniques;Testing;Text;therapy resistant;Time;Transgenic Mice;Vascularization;Work

PROJECT_TITLE: Defining and Manipulating the Endothelial Niche in Myelodysplastic Syndromes

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Precision Medicine

ORG_CITY: SHERMAN OAKS

ORG_NAME: TRETHERA CORPORATION

PHR: PROJECT NARRATIVE With cancer as the second leading cause of death in the US, there remains a pressing unmet need for new, more effective cancer therapeutics. Trethera has developed a small molecule drug, TRE-515, that inhibits deoxycytidine kinase (dCK), a rate limiting enzyme in the salvage pathway of nucleotide biosynthesis. Cancer cells utilize the salvage pathway to support rapid proliferation. TRE-515 holds an open IND and has been piloted in a dose escalation trial to establish preliminary dose, safety, and tolerability. The proposed Phase 1 dose expansion clinical trial will deploy a plasma deoxycytidine (dC) assay and a novel PET probe dCK imaging approach as complementary biomarkers to monitor drug activity and assess preliminary antitumor activity.

PI_NAMEs: SCHULTZ, KENNETH  (contact)

PROGRAM_OFFICER_NAME: FRANCA-KOH, JONATHAN C

PROJECT_TERMS: absorption;Aftercare;Area;Biological Assay;Biological Markers;biopharmaceutical industry;cancer cell;Cancer Patient;Cause of Death;Cell division;Clinical;clinical development;clinical practice;Clinical Protocols;Clinical Trials;Clofarabine;cohort;companion diagnostics;Companions;Data;Deoxycytidine;Deoxycytidine Kinase;deoxyribonucleoside triphosphate;Deoxyribonucleosides;Deoxyuridine;Dependence;Development;DNA biosynthesis;Dose;Drug Kinetics;Drug Monitoring;Drug Targeting;efficacy evaluation;Ensure;Enzymes;Evaluation;FDA approved;Future;Goals;Half-Life;Hour;imaging approach;improved;in vivo monitoring;inhibitor;invention;liquid chromatography mass spectrometry;male;Malignant Neoplasms;Measurement;Measures;Mediating;Methods;Monitor;novel;novel marker;Nucleosides;Nucleotide Biosynthesis;Nucleotides;open label;Oral;Outcome;Pathway interactions;patient response;Patient Selection;patient stratification;Patients;Pharmaceutical Preparations;Pharmacodynamics;Phase;Phase I Clinical Trials;phase I trial;Phase II Clinical Trials;Plasma;Positron-Emission Tomography;Proliferating;Qualifying;radiotracer;Refractory;Regimen;Resources;response;response biomarker;Safety;safety assessment;Sampling;Serum;side effect;small molecule;small molecule inhibitor;Solid Neoplasm;Stable Disease;success;Therapeutic;Time;treatment response;trial design;tumor;tumor growth;uptake;Validation;women patients;Work

PROJECT_TITLE: Development of a Novel, Targeted Small Molecule Inhibitor of the Nucleotide Salvage Pathway to Treat Underserved Tumor Types

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-R(12)B]


ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: The mission of the SWEHSC is to facilitate and implement innovative research and community engagement aimed at understanding the mechanisms underlying environmental health risks and disease among people living in arid environments undergoing climate change. The SWEHSC has been a driving force behind the advancement of environmental research related to arid environments through the organization of three main research themes: 1) Environmental Exposures to Underserved Southwest Populations, 2) Environmental Lung Disease, and 3) Adaptive Responses to Environmental Stress.

PI_NAMEs: CHERRINGTON, NATHAN J (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Address;Administrative Coordination;Affect;Air;Air Pollutants;arid land;Aridity;Arizona;Arsenic;career development;climate change;Coal;Collaborations;Communication;Communities;community center;community engagement;Consultations;Core Facility;Desert Climate;Development;Disease;driving force;Droughts;Dust;Ensure;Environment;Environmental Exposure;Environmental Health;environmental stressor;exposure route;Exposure to;Faculty;Focus Groups;Fostering;Funding;Future;Geographic Locations;Goals;ground water;Health;Health Hazards;Health Professional;Health Resources;Health Sciences;Human;human subject;Humidity;improved;Infrastructure;Inhalation;Inhalation Exposure;innovation;instrumentation;interdisciplinary collaboration;Interdisciplinary Study;International;Latinx;Lead;Lung Diseases;Methodology;Mexico;Mission;Molecular;Native American community;Native Americans;Needs Assessment;Outcome;outreach;Oxidative Stress;Pathway interactions;Personal Satisfaction;Persons;Pilot Projects;Planets;Policy Maker;Population;Prevalence;programs;Public Health;recruit;Research;Research Personnel;Resource Development;respiratory;response;Rest;Risk;Rural Community;Science;Scientist;Serinus;skills;Southwestern United States;Strategic vision;Stress;success;Translational Research;Translations;Ultraviolet Rays;Uncertainty;Universities;Water;Water Supply;welfare;Wildfire

PROJECT_TITLE: Southwest Environmental Health Sciences Center

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(P)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Address;Advisory Committees;Airway Disease;Area;Aridity;Arizona;Asthma;authority;base;Brain;Budgets;Cancer Center;career;career development;cellular imaging;Charge;Child;climate change;Collaborations;Communication;Communities;community advisory board;community engagement;Community Outreach;Complex;Core Facility;cost effective;design;Development;Diabetes Mellitus;direct application;Disease;Disparity;Education;Effectiveness;Ensure;Environment;Environmental Exposure;Environmental Health;experience;Exposure to;Faculty;Focus Groups;Fostering;Goals;Health;health disparity;health knowledge;health science research;Health Sciences;Heart;Human Resources;improved;Infrastructure;innovation;Interdisciplinary Study;International;Investigation;Investments;Latinx population;Lead;Leadership;Lung Diseases;Medical;member;Metabolism;Mexico;Mission;National Institute of Environmental Health Sciences;Native Americans;Native-Born;Obesity;operation;organizational structure;outreach;outreach program;Persons;Pilot Projects;Play;Population;Program Development;programs;public health intervention;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Resources;response;Risk;Role;Rural Population;Science;Scientist;Skin Cancer;Strategic vision;Stress;Structure;success;symposium;Talents;Technology;Training;Training Programs;Translating;Translational Research;Translations;tribal leader;Universities;Vision;web site;Youth

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS]


NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: BOSTON

PHR: During the development and aging of the blood forming system, blood stem cells change, and this is reflected in differences in the types of blood diseases that affect infants, children, and adults. Many blood diseases are characterized by inappropriate activation of infant/juvenile programs of blood formation in the young or mature adult. This proposal is focused on understanding the molecular control of how blood stem cells normally change during development and aging and how this process is disrupted in blood disease.

PI_NAMEs: ROWE, ROBERT GRANT (contact)

PROJECT_TERMS: Adolescent;Adult;Affect;Age;age related;Aging;Biological Assay;Blood;blood formation;Cell Maturation;Cells;Child;Clinical;Collaborations;Complement;Data;Development;Developmental Biology;Disease;Down-Regulation;Dysmyelopoietic Syndromes;Ectopic Expression;Enhancers;Equilibrium;Erythroid;experience;Family;fetal;Fetal Hemoglobin;Gene Combinations;Gene Expression;Gene Expression Profiling;Genetic Transcription;Globin;Goals;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic stem cell aging;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Hematopoietic System;Histone H2A;Histones;Immune system;improved;Infant;innovation;Investigation;knock-down;Knowledge;Laboratories;Lymphocyte;Lysine;Maps;MicroRNAs;Modeling;Molecular;Mus;Myelogenous;Organism;Outcome;Output;overexpression;paralogous gene;Pathway interactions;Pattern;pediatric patients;Polycomb;Positioning Attribute;Process;programs;Property;Regulation;Repression;Repressor Proteins;Research;RNA-Binding Proteins;Role;self-renewal;stem cell function;stem cell self renewal;System;Testing;Titrations;Transcript;transcription factor

PROJECT_TITLE: Control of hematopoietic maturation by Lin28b/let-7