NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Hypertension;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: NEUROLOGY

ORG_STATE: TX

PHR: Project Narrative The overarching goal of this study is to determine whether effective treatment of hypertension impacts brain blood flow, amyloid, and tau, hallmarks of Alzheimer’s disease (AD), in older adults who are at high risk of dementia. Furthermore, we will determine the impact of hypertension treatment on brain white mater integrity and neural network connectivity and their relationship to brain amyloid and tau deposition. The new knowledge obtained is potentially important for development of multidomain strategies for dementia prevention and treatment.

PI_NAMEs: VONGPATANASIN, WANPEN ;ZHANG, RONG  (contact);ZHU, DAVID C

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: abeta accumulation;Abeta clearance;Adult;Age;aged;Aging;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;arm;arterial stiffness;Biological;Biological Process;blood oxygen level dependent;Blood Pressure;blood pressure medication;blood-based biomarker;Brain;Cardiovascular Diseases;Cerebral small vessel disease;Cerebrospinal Fluid;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Dementia;dementia risk;Deposition;Development;effective therapy;Enrollment;Etiology;Family history of;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;glymphatic system;Goals;Healthcare;high risk;human old age (65+);Hypertension;hypertension treatment;Impaired cognition;improved;Incidence;indexing;Injury;insight;Intervention;Isolated systolic hypertension;Knowledge;late life;Magnetic Resonance Imaging;Measures;Memory;Meta-Analysis;middle age;National Institute on Aging;neural network;Neurocognitive;neuroimaging;neuropathology;older adult;Outcome;Participant;Pathogenesis;Pathology;Perfusion;Pharmacologic Substance;Positron-Emission Tomography;prevent;Prevention;Randomized;Regulation;Research;Rest;Risk;Risk Factors;Risk Marker;Risk Reduction;Rodent;Role;Signal Transduction;Societies;Stroke;tau Proteins;treatment as usual;white matter;White Matter Hyperintensity;β-amyloid burden

PROJECT_TITLE: Impact of Intensive Treatment of Systolic Blood Pressure on Brain Perfusion, Amyloid and Tau in Older Adults (IPAT-study)


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE One gene can produce many proteins that are minor variants of each other. Cancer is not just caused by mutations in genes, but these variant gene products, called “proteoforms”, but most cancer models do not include this critical information. This project will derive innovative network biology approaches to completely model these protein variants, for improved biomarker and target drug discovery.

PI_NAMEs: PRATT, DEXTER  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Alternative Splicing;Area;Binding;Biological;Biological Markers;Biology;Cancer Model;Collaborations;Data;Databases;drug discovery;Drug Targeting;Exhibits;gene product;Genes;genetic variant;improved;innovation;insight;Internet;Malignant Neoplasms;Methodology;Minor;Modeling;Molecular;Mutation;network models;novel;Pathway Analysis;Protein Isoforms;Proteins;Resources;Specific qualifier value;System;tool;Variant;Visualization;web app

PROJECT_TITLE: IMAT-ITCR Collaboration: A NOVEL METHODOLOGY AND WEB APPLICATION FOR REPRESENTING PROTOFORM DIVERSITY IN CANCER NETWORK MODELS


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Genetics

ORG_CITY: MILWAUKEE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative This supplement to the HRDP R24 resource grant aims to make the HXB/BXH recombinant inbred panel available to the research community through successful import of the rat strains from the Czech Republic to the US. This project will ensure that these models are pathogen free and available for use by investigators. Through the parent award, these models whole genome sequencing and broad phenotypic characterization will be publicly available.

PI_NAMEs: DWINELL, MELINDA R (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Academy;Administrative Supplement;animal facility;animal resource;Animals;Attention;Biomedical Research;Chromosome Mapping;clinical translation;clinically relevant;Communities;cost;cost effective;Czech Republic;Derivation procedure;Embryo;embryo cryopreservation;Ensure;Financial Support;genome sequencing;genomic data;Goals;Grant;Health Status;Hybrids;Inbred Strain;Inbred Strains Rats;Inbreeding;Individual;Institution;Laboratory Research;Maintenance;Measures;medical schools;Modeling;parent grant;parent project;parenting intervention;pathogen;Phenotype;phenotypic data;Physiology;Process;programs;Protocols documentation;Quality Control;R24;Rat Strains;Rattus;Recombinants;Research;Research Personnel;Resources;Retirement;Science;Shipping;System;Testing;Translations;Vendor;whole genome;Wisconsin

PROJECT_TITLE: Hybrid Rat Diversity Program - Import of HXB/BXH panel


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

ORG_STATE: MO

PHR: There is a need to identify the causes of the most severe form of male infertility, non-obstructive azoospermia (NOA), where there is spermatogenic failure resulting in an ejaculate with no sperm. NOA men have an increased risk of serious diseases, such as cancer, when compared with fertile men or men with sperm in their ejaculates. However, the link between their infertility and their increased disease risk has remained elusive.

PI_NAMEs: LAMB, DOLORES JEAN (contact)

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Address;Age;Alkylating Agents;bile duct;Breast;Canada;cancer diagnosis;cancer risk;cancer type;Chromosome abnormality;Clinic;cohort;Colon;Consultations;Couples;Data;Databases;Defect;Development;Diagnosis;Disease;disorder risk;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Disorder;DNA Repair Gene;Double Strand Break Repair;Early Intervention;Ejaculation;Endometrial;Epigenetic Process;Etiology;Evaluation;Exhibits;Exposure to;Failure;Fertilization in Vitro;Gene Deletion;Gene Expression;Gene Mutation;gene repair;General Population;Genes;Genetic;Genetic Predisposition to Disease;Genomic Instability;Genomics;Health;Hematology;Hereditary Nonpolyposis Colorectal Neoplasms;high risk;Homologous Gene;homologous recombination;homologous recombination deficiency;Human;Immune System Diseases;Impairment;improved;Incidence;Infertility;Injections;insight;Institution;Intracytoplasmic Sperm Injections;Investigation;Kidney;Knowledge;Laboratories;Link;male;Male Infertility;Malignant neoplasm of brain;Malignant Neoplasms;Medical;medical schools;Meiosis;men;Mismatch Repair;Mismatch Repair Deficiency;Molecular;mouse model;Mutation;Nature;neoplasm registry;Organ;Outcome;Ovarian;Pancreas;Pathology;Patients;Play;Premature Ovarian Failure;Production;Prostate;Proteins;Publishing;Recording of previous events;Registries;Reproductive Medicine;response;Risk;Seminal fluid;Small Intestines;sperm cell;Sperm Count Procedure;Stomach;Syndrome;Testing;Testis;Thyroid Gland;Time;Treatment Cost;Urinary tract;urologic;Uterus;Variant;virtual;Work;young man

PROJECT_TITLE: DNA Repair Deficiencies in Infertile Men and Cancer Risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-J(55)R]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Mental Health;Neurosciences;Pediatric;Physical Activity;Prevention;Sleep Research;Substance Misuse;Underage Drinking

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

PHR: PROJECT NARRATIVE This supplement requests funds to tailor an ad-hoc pipeline for data analysis of the high-density NCANDA dataset (mNCANDA + Fitbit) and prepare a dataset and data dictionary of the summary variables that can be added to the main NCANDA dataset for public release. These data capture how changes in alcohol use and other substances are associated with dynamic changes in sleep, physical activity, and heart rate. This supplement, therefore, supports the goals of NCANDA-A to identify neural, behavioral, and environmental risk markers for problem adolescent and emerging adult alcohol use, determine the impact of alcohol exposure variations (timing, dose, and duration) on brain maturation and behavior, identify characteristics predicting AUD resilience and recovery, and characterize sex-specific risk.

PI_NAMEs: BAKER, FIONA C (contact);DE ZAMBOTTI, MASSIMILIANO

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Abstinence;Acceleration;Acute;Address;Administrative Supplement;Adolescence;Adolescent;adolescent binge drinking;Adult;Adverse effects;Affect;Affective;Age;Alcohol consumption;alcohol cue;alcohol effect;alcohol expectancy;alcohol exposure;alcohol use disorder;alcohol use initiation;Alcohols;Behavior;Behavior assessment;Behavioral;binge drinking;Biological;Brain;Characteristics;Clinical;Cognition;Cognitive;cognitive control;cognitive performance;cohort;Communities;COVID-19 impact;COVID-19 pandemic effects;cue reactivity;Data;data analysis pipeline;data dictionary;Data Set;data sharing;Dedications;density;design;Development;Distress;Dose;drinking;drinking onset;early onset;Economics;emerging adult;emerging adulthood;Emotional;Ensure;Environmental Risk Factor;Event;experience;externalizing behavior;Family;Female;fitbit;Frequencies;Funding;Goals;Health;heart function;Heart Rate;Heavy Drinking;improved;Individual;information processing;International;Life;Life Stress;Link;Machine Learning;male;Measures;Mediating;Mission;Modeling;Monitor;Moods;multimodal neuroimaging;neural;neurodevelopment;neuroimaging;neuropsychiatry;novel;Outcome;Outcome Measure;pandemic disease;Patient Recruitments;Patient Self-Report;Pattern;Personal Satisfaction;Physical activity;Polysomnography;Positioning Attribute;post-pandemic;pre-pandemic;Process;Protocols documentation;Psychopathology;Recording of previous events;Recovery;recruit;Research Personnel;Research Project Grants;resilience;Rest;retention rate;Risk;Risk Marker;Sampling;sex;Sex Differences;Site;Sleep;Sleep disturbances;social;Stress;Structure;substance use;Symptoms;Technology;Testing;underage drinking;Variant;Work

PROJECT_TITLE: National Consortium on Alcohol and NeuroDevelopment in Adolescence - SRI International Research Project Site (NCANDA-SRI)


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: ALBUQUERQUE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative Regulatory T cells (Tregs) are one of the main immune components that control autoimmune disease and are selectively disrupted in the setting of Interleukin-2 (IL-2) signaling deficiencies. Numerous studies are examining the therapeutic potential of low-dose IL-2, but these evaluations would benefit by a more complete knowledge concerning the mechanisms by which IL-2 effects mature Tregs. This study will address fundamental questions surrounding the contribution of IL-2 receptor signaling for Treg survival, differentiation, and function to aid in the therapeutic application of this cytokine and to better define potential targets related to IL-2/IL-2 receptor genetic risk for autoimmunity.

PI_NAMEs: SHOUSE, ACACIA NICOLE (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Ablation;Acute;Adoptive Transfer;Adrenal Cortex Hormones;Affect;American;Animals;Apoptosis;ATAC-seq;Autoimmune Diseases;Autoimmunity;autoreactive T cell;Bioinformatics;Biological Assay;Biology;Bypass;Cause of Death;Cell Physiology;Cell Survival;Cellular biology;Complex;Complication;cytokine;Data;Defect;Development;Disease;Dose;Drops;Epigenetic Process;Evaluation;Exhibits;experience;Fellowship;Flow Cytometry;Gene Modified;Genetic Risk;Genetic Transcription;Heterogeneity;Homeostasis;Human;IL2RA gene;Immune;improved;in vitro Assay;in vivo;Incidence;Inflammatory;Insulin-Dependent Diabetes Mellitus;Interleukin 2 Receptor;Interleukin-2;Investigation;Knock-out;Knockout Mice;Knowledge;Lead;Lupus;Malignant Neoplasms;Manipulative Therapies;Measures;Mediating;Memory;Metabolism;Midlife women;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Pathway interactions;Peripheral;peripheral tolerance;Play;Population;Positioning Attribute;Predisposition;Prevention;Process;Proliferating;Receptor Signaling;Recombinant Interleukin-2;Regulatory T-Lymphocyte;Research;Role;Self Tolerance;side effect;Signal Transduction;single-cell RNA sequencing;Sorting;T cell differentiation;T-Lymphocyte Subsets;Techniques;Therapeutic;tool;Training;Transcription Process;transcriptome sequencing

PROJECT_TITLE: Mechanisms of regulatory T cell processes by IL-2" - TRANSFER to UNM


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Behavioral and Social Science;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PI_NAMEs: COLLMAN, RONALD G (contact)

PROGRAM_OFFICER_NAME: WONG, ELAINE WAI-KEN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Administrator;Advisory Committees;Advocate;Affect;Area;arm;Behavioral Sciences;Biometry;Botswana;Businesses;Caring;Cells;Clinical;Collaborations;Communication;Communities;community advisory board;community engagement;community research;comorbidity;Data Science;Development;diversity and inclusion;Education;Ensure;Evaluation;Faculty;Feedback;Funding;Generations;Goals;Grant;Health;HIV;HIV/AIDS;Immune;Immunology;implementation science;Individual;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;International;Lead;Leadership;meetings;member;Mentors;Modeling;Molecular;Monitor;multidisciplinary;next generation;novel;organizational structure;outreach;outreach program;Pediatric Hospitals;Pennsylvania;Philadelphia;Policies;Positioning Attribute;Prevention;Process;programs;Public Health;public health priorities;recruit;Research;Research Personnel;Research Priority;Resource Allocation;Resource Sharing;Resources;Role;Science;Scientific Advances and Accomplishments;Secure;Services;social determinants;Social Sciences;sound;Strategic Planning;synergism;Technology;The Wistar Institute;Tissues;Training;Underrepresented Minority;United States National Institutes of Health;Universities;Vaccines;Virus;Woman;Work;working group

PROJECT_TITLE: Administrative Core A


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Clinical Research;Digestive Diseases;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposed research will be the first longitudinal study to examine the effects of early-life exposure to breast milk poly- and perfluoroalkyl substances (PFAS) on infant growth trajectories and risk for childhood obesity in the context of the infant gut microbiome and fecal metabolome. Study findings will address a critical gap in our current understanding of breast milk PFAS and their obesogenic effects. Results from this proposal are expected to have significant implications in terms of identifying alterations in gut bacterial species and/or fecal metabolic pathways that contribute to obesity risk. These findings can be used in future novel intervention modalities applicable to Hispanic infants who are at increased risk of early-onset obesity.

PI_NAMEs: ALDERETE, TANYA LYNN (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: 2 year old;Actinomyces;Adult;Age;Age Months;Amino Acids;Archives;Bacteria;Bacteroides;bile acid metabolism;Bile Acids;Biological;Blood;Body mass index;Breast Cancer Detection;Breast Feeding;California;Canada;Cardiovascular Diseases;Cardiovascular system;Chemicals;Child;Childhood;cohort;comorbidity;critical period;Data;Development;Disease;drinking water;Dryness;early life exposure;early-onset obesity;energy balance;environmental chemical;Event;Excretory function;experimental study;exposed human population;Exposure to;fatty liver disease;fecal metabolome;Feeding behaviors;Funding;Future;Goals;Growth;gut bacteria;gut microbiome;gut microbiota;high risk;Hispanic;Hispanic Populations;Human;Human Milk;improved;infancy;Infant;infant gut microbiome;insight;Intervention;Lactation;Lactobacillus;Life;Link;lipid biosynthesis;Lipids;Literature;Longitudinal Studies;Maternal Health;Measures;Metabolic Pathway;Metabolic syndrome;metabolomics;Metagenomics;microbial;Milk;Minority Groups;Modality;Mothers;multidisciplinary;multiple omics;Newborn Infant;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Obesity Epidemic;obesity in children;obesity prevention;obesity risk;obesity treatment;obesogenic;Physical activity;physical inactivity;Poly-fluoroalkyl substances;postnatal;Predisposition;Pregnancy;prenatal;prenatal exposure;prevent;Preventive measure;Probiotics;Production;public health priorities;rapid growth;rapid infant weight gain;Reporting;Research;Research Personnel;Risk;Sampling;screening;Source;Spottings;stool sample;Subgroup;Testing;transmission process;underserved community;Unhealthy Diet;United States National Institutes of Health;Volatile Fatty Acids;Weight;Youth

PROJECT_TITLE: Perfluoroalkyl Substances and the Gut Microbiome and Fecal Metabolome: Implications for Obesity Risk in Hispanic Children

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Recovery Support Services;Rehabilitation;Substance Misuse

ORG_CITY: SOLON

ORG_NAME: THRIVE DIGITAL HEALTH, LLC

ORG_STATE: OH

PHR: PROJECT NARRATIVE Thrive Digital Health (TDH) is developing and testing a novel technology platform to enhance, standardize and scale the training of the Peer Recovery Supporter workforce. Peer Recovery Support Services are being increasingly implemented across the U.S. as a strategy to fill care gaps, and this platform will enable public and private organizations to efficiently and cost-effectively build their PRSS workforce, and support that workforce on an ongoing basis as they serve individuals recovering from alcohol and other substance use disorders. Over time, the innovations resulting from this project will significantly reduce costs for individuals, public and private payers, the healthcare system, and society at large.

PI_NAMEs: PESCE, CHRISTOPHER NEIL (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Acceleration;addiction;Address;Adherence;Adopted;alcohol relapse;Alcohols;Behavior Therapy;Caring;Client satisfaction;Clinical;commercialization;Communities;cost;Country;Critical Care;Data;demographics;Development;digital;digital health;Drug Courts;E-learning;Educational process of instructing;Effectiveness;Ensure;Epidemic;Equity;evidence base;Feedback;Goals;graduate student;Growth;Health;Health Personnel;Health Technology;Healthcare Systems;Hospitals;implementation fidelity;improved;Individual;innovation;Instruction;International;Knowledge;Libraries;Lived experience;Marketing;Methods;Modeling;National Institute on Alcohol Abuse and Alcoholism;new technology;novel;peer;peer recovery;peer support;Phase;Population;Positioning Attribute;Privatization;Provider;Randomized, Controlled Trials;Recovery;recovery services;Recovery Support;reduced alcohol use;Research;Research Priority;Role;service delivery;service programs;service providers;Services;skills;Small Business Innovation Research Grant;Social support;Societies;Specialist;Specific qualifier value;Standardization;stem;Substance Use Disorder;success;System;Technology;technology platform;Teleconferences;Testing;Time;Training;treatment center;treatment services;usability;Variant;Work

PROJECT_TITLE: DEVELOPMENT OF A NOVEL PEER RECOVERY SUPPORTER TRAINING PLATFORM TO DISSEMINATE EVIDENCE-BASED TRAINING AT SCALE


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PI_NAMEs: WYATT, RICHARD THOMAS (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: Project Narrative Glucocorticoids are required to treat various diseases with inflammatory components. However, therapy with this class of drug leads to insulin resistance and diabetes. This project employs novel mouse models to define key cellular mechanisms relating to lipid metabolism in efforts to understand and eventually prevent these adverse effects to improve metabolic health.

PI_NAMEs: COLLIER, JAMES JASON;NOLAND, ROBERT CHARLES (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Adipose tissue;Adverse effects;adverse outcome;Agonist;Anabolism;Animal Model;Anti-Inflammatory Agents;Automobile Driving;Basic Science;carbohydrate metabolism;Carbon;Carnitine Palmitoyltransferase I;CD36 Antigens;Cell Culture Techniques;Ceramides;chemical synthesis;Chronic;Circulation;Clinical;Clinical Sciences;Complement;Data;Development;Diabetes Mellitus;diabetic;Disease;Ensure;Enzymes;Essential Drugs;Event;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;Floods;Functional disorder;Gene Modified;Genetic;genetic approach;Genetic Models;Glucocorticoid Receptor;Glucocorticoids;Glucose;glucose metabolism;Health;Hexosamines;Hydrocortisone;Hyperglycemia;Iatrogenesis;Impairment;improved;in vivo;in vivo evaluation;Inflammatory;innovation;insight;Insulin;Insulin Receptor;Insulin Resistance;insulin signaling;Intervention;Intramuscular;Link;Lipase;lipid metabolism;Lipids;Lipolysis;Mediating;Metabolic;Metabolic dysfunction;Mitochondria;Modality;Modeling;mouse model;Mus;Muscle;novel;O-GlcNAc transferase;Outcome;Outcome Study;Oxidative Stress;Pathologic;Pathology;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;prevent;Process;Production;Property;Proteins;Publishing;Regimen;Reporting;response;Risk;Role;Route;Series;side effect;Signaling Molecule;Skeletal Muscle;Starvation;Testing;Thinness;Tissues;translocase;uptake

PROJECT_TITLE: Mechanisms of glucocorticoid-induced metabolic dysfunction in skeletal muscle

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-D(02)M]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Plasmodium ovale and Plasmodium vivax are resistant to many current malaria control interventions, due to evolutionary advantages affecting transmission and relapse. They are increasingly identified in infections in Africa and, in the case of vivax, potentially evolving to overcome limitations to red blood cell invasion. This proposal seeks to provide the evidence base and to develop tools needed to face challenges associated with control of relapsing malarias by providing fundamental knowledge about the infectious reservoir and vectors involved in transmission, developing tools to understand relapse and defining mechanisms by which vivax malaria may be evolving to expand its range and impact in Africa.

PI_NAMEs: DINGLASAN, RHOEL DAVID RAMOS;JULIANO, JONATHAN J (contact);NSANGO, SANDRINE

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Affect;Africa;African;Anopheles Genus;Anti-malarials;Asia;Binding Proteins;Biological;Biological Assay;Biology;Blood;Cameroon;Cells;Central Africa;Clinic;Communities;Community Surveys;Country;Culicidae;deep sequencing;density;design;Diagnostic;Disease;epidemiologic data;Epidemiologist;Erythrocytes;Ethiopia;evidence base;Face;feeding;genome sequencing;genomic locus;genomic tools;Genomics;Genotype;Human;Immune;Individual;Infection;insight;Intervention;Invaded;Investigation;Investments;Kenya;Knowledge;Larva;Left;Life Cycle Stages;Ligands;Liver;Longitudinal cohort;Madagascar;Malaria;malaria infection;Molecular;molecular diagnostics;Monitor;neglect;Parasitemia;Parasites;Pattern;Periodicity;Plasmodium falciparum;Plasmodium ovale;Plasmodium vivax;point of care;point-of-care diagnostics;Prevalence;Production;Proteins;Proteomics;recurrent infection;Relapse;relapse prediction;Research;Research Personnel;resilience;Resistance;Sampling;screening;Shapes;single cell sequencing;Site;Skin;Sorting;Surveys;Tanzania;Time;tool;transcriptomics;transmission process;Uganda;vector;vector competence;Vivax Malaria;whole genome;Work

PROJECT_TITLE: Relapsing malaria in Africa: mechanisms for persistence amid falciparum decline

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Urologic Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PI_NAMEs: CAPARON, MICHAEL G. (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: 2-hydroxypyridine;Address;Antibiotic Resistance;antibiotic resistant infections;Antibiotic Therapy;Antibiotics;Bacillus subtilis;Bacteria;Bacterial Infections;bactericide;Biochemical;catheter associated UTI;Cause of Death;Cell Physiology;Cells;Cessation of life;chemical genetics;Chemicals;Clindamycin;Clinical;Clostridium difficile;Collaborations;combat;Data;density;Development;Dose;Drug Design;Drug resistance;drug resistant microorganism;druggable target;efficacy evaluation;Environment;Erythromycin;Essential Genes;Evaluation;experimental study;Expression Library;Family;Fibrinogen;fitness;Genes;Genetic;genetic approach;genetic resource;global health emergency;Goals;Gram-Positive Bacteria;Healthcare;Hospitals;Human;improved;In Vitro;in vitro Model;in vivo;in vivo evaluation;Infection;Infectious Skin Diseases;innovation;Lead;methicillin resistant Staphylococcus aureus;Methodology;Microbe;Microbial Biofilms;Microbiology;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;mouse model;Multi-Drug Resistance;multi-drug resistant pathogen;Mus;next generation;Nosocomial Infections;novel;Organic Chemistry;Organism;overexpression;pathogen;Pathogenesis;Pathogenicity;Patients;polymicrobial biofilm;Positioning Attribute;Prevalence;Process;Property;Recording of previous events;Resistance;Resistant Streptococcus pneumoniae;Respiratory Tract Infections;scaffold;Skin;soft tissue;Soft Tissue Infections;Solubility;standard of care;Streptococcus Group B;Streptococcus pyogenes;Structure;Structure-Activity Relationship;synergism;System;Talents;Testing;therapeutic development;therapeutic target;Tissues;Toxic effect;Translations;Urinary tract;Urinary tract infection;Urine;Vancomycin resistant enterococcus

PROJECT_TITLE: GmPcides: Componds that disarm antibiotic resistance in multiple gram-positive pathogens


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Zika Virus

ORG_CITY: PORTLAND

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The proposed research evaluates DENV and ZIKV immunity in humans living in endemic and non-endemic settings. This knowledge is critical to understanding the potency, breadth, determinants and correlates of ZIKV and DENV immunity as well as effective evaluation and improvement of this vaccine that is critical to control this globally important disease. The results of this project are highly and directly relevant to the NIH’s mission fostering innovative research strategies to reduce the burden of illness and disease.

PI_NAMEs: MESSER, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: FLORESE, RUTH HUAB

PROJECT_TERMS: Antibodies;Antibody titer measurement;Antibody-mediated protection;arthropod-borne;Biological Assay;burden of illness;Cells;cohort;Cohort Studies;Collaborations;Communities;Complex;Data;Dengue;Dengue Vaccine;Dengue Virus;Dependence;Diagnostic;Disease;Disease Surveillance;Epidemic;Evaluation;Flavivirus;Fluorescence-Activated Cell Sorting;Fostering;Frequencies;Future;Human;Immune;Immunity;immunogenic;Immunologic Memory;improved;Individual;Infection;innovation;Knowledge;Label;Link;Maintenance;Memory;Memory B-Lymphocyte;Methods;Mission;Modeling;mosquito-borne;Natural Immunity;neutralizing antibody;Nicaragua;Nonstructural Protein;novel;Observational Study;Oregon;Pathogenicity;Peripheral Blood Mononuclear Cell;Peru;Play;Predisposition;Primary Infection;Property;prospective;Public Health;Puerto Rico;Research;response;Role;Sentinel;Serotyping;Serum;Specificity;System;Testing;Therapeutic;Time;transmission process;United States National Institutes of Health;Vaccine Design;vaccine development;vaccine evaluation;Vaccines;Variant;Viral Proteins;Virus;Work;World Health Organization;Zika Virus

PROJECT_TITLE: Flavivirus immunity in endemic and non-endemic human cohorts


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: ATLANTA

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE To advance both a prophylactic HIV-1 vaccine and a functional cure, this Consortium for Innovative HIV/AIDS Vaccine and Cure Research in Non-Human Primates will pursue two main research foci. Research Focus 1 is aimed at optimizing and understanding the mechanism of protection for highly protective vaccine. Research Focus 2 aims to determine whether combining the optimized vaccine concept with latency reversing agents and immune modulators can result in sustained suppression of pathogenic SHIV infection following interruption of high active antiretroviral treatment.

PI_NAMEs: AMARA, RAMA RAO ;HUNTER, ERIC  (contact);MASOPUST, DAVID

PROGRAM_OFFICER_NAME: BOGGIANO, CESAR AUGUSTO

PROJECT_TERMS: Address;Adjuvant;Animals;Antibodies;Antibody Formation;Antibody Response;antigen challenge;Antigens;antiretroviral therapy;B-Lymphocytes;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular biology;Clinical Research;delivery vehicle;Discipline;Disease remission;Environment;Epigenetic Process;Gene Expression Profile;Goals;Highly Active Antiretroviral Therapy;HIV;HIV envelope protein;HIV resistance;HIV vaccine;HIV-1 vaccine;Immune;Immune response;Immunity;Immunization;Immunomodulators;Individual;Infection;innovation;Interruption;Intravenous;latent HIV reservoir;Macaca;Macaca mulatta;Mediating;Mucosal Immune Responses;Mucous Membrane;neutralizing antibody;nonhuman primate;novel;operation;Pathogenicity;Play;Population;Preventive vaccine;Production;Productivity;programs;prophylactic;Proteins;Refractory;Research;Research Personnel;Resistance;Resources;response;Role;Scheme;Serum;Shock;Signal Transduction;simian human immunodeficiency virus;single cell analysis;SIV;Specificity;Structure of germinal center of lymph node;success;synergism;T cell response;T-Lymphocyte;Techniques;therapeutic vaccine;Tissues;transcriptomics;Vaccinated;Vaccination;Vaccine Design;vaccine efficacy;vaccine response;Vaccine Therapy;Vaccines;vector;vector vaccine;Viral Antigens;viral rebound;Viral reservoir;Viral Vector;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: B and T Cell Biology of Protection from and Eradication of SIV/SHIV Infection


ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative This proposal develops a novel method for carrying out multiplexed measurements on large numbers of single cells. The methods developed will allow researchers to leverage new comprehensive “atlases" of tumor cells for a wide range of studies from evaluating the effects of new drug treatments, to identifying tumor cells that predict patient outcomes. Within this advanced development grant, we move from established technical capabilities to two mature fully-working methods for single cell analysis.

PI_NAMEs: KLEIN, ALLON MOSHE (contact);MAZUTIS, LINAS

PROJECT_TERMS: Acceleration;Acute;Address;Administrative Supplement;Advanced Development;Affinity;Animals;anti-cancer research;Antibodies;aqueous;Atlases;Benchmarking;Binding;Biological;Biological Assay;Buffers;Calibration;capsule;Cell Separation;Cell Surface Proteins;Cells;Clinical;cohort;Collaborations;Complex;complex data;computational suite;computerized tools;cost;crosslink;Cytometry;Cytotoxic agent;Data;data quality;Data Set;Dedications;Development;digital;digital pathology;dimension reduction;DNA;Ensure;Enzymes;Evolution;experimental study;Flow Cytometry;Genes;Genomics;Goals;Grant;high dimensionality;Human;Hydrogels;Image;Immobilization;Immune;Immune checkpoint inhibitor;improved;Individual;Location;Maps;Measurement;Measures;medical schools;Membrane Proteins;Messenger RNA;Methods;Microcapsules drug delivery system;microfluidic technology;Microfluidics;Microspheres;Modality;Modification;Molecular;multiple omics;multiplexed imaging;nanolitre scale;neoplastic cell;new technology;Noise;novel;novel therapeutics;Oils;parent grant;particle;Patient-Focused Outcomes;Patients;Periodicity;Permeability;Phenotype;Population Heterogeneity;Process;Productivity;Prognosis;programs;Quality Control;Reaction;Reagent;Reproducibility;Research Personnel;resilience;Resources;Salts;Sampling;Services;Signal Transduction;single cell analysis;single cell genomics;single-cell RNA sequencing;Slide;Software Engineering;Specimen;Stains;Standardization;Stromal Cells;Surveys;targeted treatment;Technology;Testing;Time;Tissue imaging;Tissue Microarray;Tissues;tool;Transcript;transcriptomics;tumor;tumor heterogeneity;tumor microenvironment;Variant;Visual;Visualization;Water;web platform;Work

PROJECT_TITLE: IMAT-ITCR Collaboration: Multiplexed Spatial Data Calibration and analysis using micro-capsules


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: This proposal focuses on the molecular mechanisms that underlie initiation and progression of valvular heart diseases, which is one of leading causes of death worldwide and highly relevant to the mission of the NIH. We will focus on studying a new regulatory protein that controls the endothelial-to-mesenchymal transition, a biological process that governs heart valve structure and function, and investigating how abnormal endothelial- to-mesenchymal results in mitral valve thickening, a common cause of mitral stenosis. We anticipate the study of this important developmental, physiological and pathological process will identify new molecular pathways that can be exploited as therapeutic targets to combat valvular heart diseases.

PI_NAMEs: JIN, ZHENG-GEN  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Ablation;angiogenesis;antagonist;Biological Process;Blood Vessels;Bone Morphogenetic Proteins;Cardiac Surgery procedures;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cell Therapy;Cells;combat;Complex;Data;Defect;design;Development;Developmental Process;Disease;Endocardium;Endothelial Cells;endothelial dysfunction;Endothelium;Family;Family member;Functional disorder;gain of function;Genes;Genetic;genetic regulatory protein;Goals;Heart;Heart Diseases;Heart Valve Diseases;Heart Valves;Homeostasis;Human;human disease;Impairment;In Vitro;in vivo;interest;Investigation;Knock-out;Knockout Mice;loss of function;Maintenance;Maps;Mediating;Mesenchymal;Mission;Mitral Valve;Mitral Valve Stenosis;Molecular;mouse model;Mus;Myocardial Infarction;Names;National Heart, Lung, and Blood Institute;Nitric Oxide;novel;novel strategies;novel therapeutic intervention;organ growth;Pathogenesis;Pathologic;Pathologic Processes;Pathology;Pathway interactions;Patients;Phenotype;Physiological;Physiological Processes;Physiology;Play;prevent;Protein Kinase;protein kinase D;Protein-Serine-Threonine Kinases;Publishing;Regulation;Reporter;Research;Role;Scheme;Series;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;single-cell RNA sequencing;Specific qualifier value;Stress;Structure;Testing;Therapeutic;therapeutic target;Tissues;transcriptome;transcriptome sequencing;United States;United States National Institutes of Health;Vascular Endothelial Growth Factors;Vasodilation;Work

PROJECT_TITLE: PKD3 and Valvular Heart Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RCCS-S(02)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Calcification of the aortic valve obstructs and disturbs blood flow leading to heart failure and high risk for stroke This research proposal will investigate the mechanisms by which non-canonical telomerase reverse transcrip- tase activity orchestrates the osteogenic reprogramming of aortic valve cells. Defining the early steps that regu- late how a healthy valve cell switches into a calcifying valve cell may uncover potential therapeutic targets which can be leveraged for the development of pharmacological treatments.

PI_NAMEs: ST. HILAIRE, CYNTHIA  (contact)

PROJECT_TERMS: 3-Dimensional;Amino Acids;Anticoagulation;aortic valve;aortic valve disorder;aortic valve replacement;ATAC-seq;Attenuated;Binding;Bioprosthesis device;Blood flow;bone;calcification;Cardiovascular Models;Cardiovascular system;Cell Reprogramming;cell type;Cells;Chemicals;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;Cleavage Under Targets and Release Using Nuclease;Coculture Techniques;Complex;Coupling;Cues;Data;Death Rate;defined contribution;Development;Diagnosis;Disease;disease model;Enzymes;Epigenetic Process;epigenome;Extracellular Space;Gene Expression Profile;Genetic;Genetic Transcription;genome-wide;Genomics;Goals;Health;Heart failure;high risk;histone modification;Histones;Human;human disease;human tissue;Hydrogels;In Vitro;in vivo;Inflammatory;interstitial cell;Investigation;Kinetics;Length;Maps;Mechanics;Mediating;Medical Care Costs;Minerals;mouse model;Multienzyme Complexes;multiple omics;Mus;Mutagenesis;mutant;novel;osteogenic;overexpression;Pathology;Pathway interactions;pharmacologic;Pharmacological Treatment;Plasmids;Play;prevent;programs;promoter;Proteins;Proteomics;recruit;Reporter;Research Proposals;response;Risk;RNA-Directed DNA Polymerase;Role;scaffold;Signal Induction;Signal Transduction;SMARCA4 gene;Source;Stat5 protein;Stimulus;Stress;stroke risk;System;Telomerase;Telomerase Inhibitor;Telomerase RNA Component;telomere;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;tissue culture;tool;Transcript;transcription factor;transcriptome;transcriptome sequencing;Visualization

PROJECT_TITLE: Telomerase Reverse Transcriptase in Aortic Valve Calcification

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Congenital Heart Disease;Heart Disease;Patient Safety;Pediatric;Precision Medicine;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Degenerative mitral regurgitation (DMR) impacts approximately 3% of the general population and 10% of adults older than 75 years, and while treatment strategies for severe DMR have evolved, clarity on the clinical effectiveness of transcatheter edge-to-edge repair (TEER) versus surgical repair remains elusive. Our proposed study will utilize the resources of our high-volume mitral valve disease referral center including advanced multimodality imaging to compare long-term clinical and patient-reported outcome measures of both treatments retrospectively and prospectively, and their clinical and imaging correlates. Our overarching goal is to generate real-world clinical data that will facilitate development of robust clinical risk scores that can ultimately inform treatment decision making for patients with severe DMR.

PI_NAMEs: GUPTA, AAKRITI  (contact)

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Address;Aftercare;age stratification;aging population;Anxiety;biomedical referral center;Cardiac;cardiac magnetic resonance imaging;Categories;Characteristics;Clinical;Clinical Data;Clinical effectiveness;clinical imaging;clinical investigation;clinical prognosis;clinical risk;Clinical Trials;cohort;comparative;comparative efficacy;Comparative Study;coronary fibrosis;Data;Decision Making;Development;digital platform;Disease;Effectiveness;effectiveness outcome;Elderly;Enrollment;Ensure;Epidemiology;experience;Fibrosis;follow-up;General Population;Goals;Head;Heart Valve Diseases;high risk;Image;imaging biomarker;Imaging Techniques;improved outcome;Incidence;individualized medicine;infancy;Informed Consent;Infrastructure;insight;Institution;interstitial;Intervention;Knowledge;Left;Left Ventricular Dysfunction;Longitudinal Surveys;Magnetic Resonance;Measurement;Measures;Mitral Valve;Mitral Valve Insufficiency;Mitral Valve Prolapse;Modeling;Morbidity - disease rate;Morphology;mortality;Multimodal Imaging;multiple chronic conditions;National Heart, Lung, and Blood Institute;older adult;older patient;Operative Surgical Procedures;Outcome;Outcome Assessment;Outcome Measure;Pain;Patient Outcomes Assessments;Patient Selection;Patient-Focused Outcomes;Patients;Perception;Perioperative;Pharmacotherapy;Postoperative Period;postoperative recovery;Prediction of Response to Therapy;Probability;programs;prospective;Prospective Studies;Quality of life;randomized trial;randomized, clinical trials;Recovery;repaired;Reporting;Research;Resources;response;Risk;Safety;safety outcomes;serial imaging;Severities;shared decision making;Sleep;Source;Specific qualifier value;Subgroup;Techniques;Technology;Testing;treatment center;treatment group;treatment strategy;treatment stratification;trend;United States National Institutes of Health;Ventricular

PROJECT_TITLE: Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation: A Comparative Study of Clinical Outcomes, Patient Experiences, and Mechanistic Insights with Multimodality Imaging

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PI_NAMEs: GOLDSTEIN, HARRIS  (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Advisory Committees;Behavioral;career;Clinical;Collaborations;college;Communication;Communities;County;Development;Education;Electronic Mail;Ensure;Epidemic;Epidemiology;Faculty;Fostering;Funding;Goals;Grant;Growth;Health;HIV;HIV diagnosis;HIV Infections;implementation process;improved;Infrastructure;Institution;Interdisciplinary Study;International;Lead;Leadership;Location;Medicine;meetings;member;Mental Health;Monitor;multidisciplinary;New York City;Newsletter;novel strategies;novel therapeutics;Occupational activity of managing finances;Outcome;Outcome Measure;Paper;Performance;prevent;Process;Productivity;programs;Public Health Schools;Publications;Recommendation;recruit;Research;Research Personnel;Research Priority;Resources;response;Scientific Advances and Accomplishments;sound;Strategic Planning;Structure;success;Surveys;synergism;Training;United States;United States National Institutes of Health;Universities;Update;uptake;web site;working group

PROJECT_TITLE: ERC Einstein Rockefeller CUNY Center for AIDS Research


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Pain Research;Patient Safety;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: Project Narrative Racial and ethnic inequities in health care quality have been described across a broad range of clinical settings, patient populations, and outcomes and it is now imperative that we move forward to develop and test interventions to mitigate and eradicate such inequities. In response to the RFA-NS-22-002: HEAL Initiative: Advancing Health Equity in Pain Management (R61/R33), the objectives of this proposal are to develop and test the impact of two interventions – 1) regularly provided clinician audit and feedback, through the provision of ‘Equity Report Cards’ and 2) provision of real time, electronic health record-embedded clinical decision support – on overcoming clinician implicit bias and mitigating inequities in the management of pain among children seeking care in the emergency department for the treatment of appendicitis or long bone fractures.

PI_NAMEs: GOYAL, MONIKA KUMARI (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: Absence of pain sensation;Accident and Emergency department;Acute Pain;Address;Age;Appendicitis;Awareness;behavior change;care delivery;Care given by nurses;care seeking;Caring;Child;Child Health;Clinical;clinical care;clinical decision support;clinical encounter;Data;Discipline of Nursing;Disparity;disparity reduction;Documentation;Electronic Health Record;Emergency department visit;Equity;ethnic disparity;Ethnic Origin;Evaluation;Evidence based intervention;Feedback;Foundations;Fracture;Goals;Guidelines;Health;health care delivery;health care disparity;health care quality;health difference;health equity;health inequalities;Health Services Accessibility;Healthcare Systems;Helping to End Addiction Long-term;Implicit Association Test;implicit bias;improved;Inequity;Information Technology;innovation;Interruption;Intervention;long bone;Measures;Nurses;Opioid Analgesics;Outcome;Outcome Measure;Pain management;Pain Measurement;pain reduction;pain score;Parents;Pathway interactions;patient oriented;patient population;Patients;pediatric emergency;Performance;Phase;Physicians;Process;Process Measure;Prospective Studies;Provider;Quality of Care;Race;racial disparity;Reporting;Research;Research Design;response;Role;simulation;Socioeconomic Status;stem;success;support tools;Testing;Time;Time Series Analysis;Unconscious State;Work

PROJECT_TITLE: PAINED: Project Addressing INequities in the Emergency Department


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PI_NAMEs: SHEYNKMAN, GLORIA  (contact);YI, S. STEPHEN

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Alternative Splicing;Area;Binding;Biological;Biological Markers;Biology;Cancer Model;Collaborations;Data;Databases;drug discovery;Drug Targeting;Exhibits;gene product;Genes;genetic variant;improved;innovation;insight;Internet;Malignant Neoplasms;Minor;Modeling;Molecular;Mutation;network models;Pathway Analysis;Protein Isoforms;Proteins;Resources;Specific qualifier value;System;tool;Variant;Visualization

PROJECT_TITLE: IMAT-ITCR Collaboration:  A Cytoscape Toolkit to Model Proteoform-Resolved Cancer Networks


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health

ORG_CITY: BETHLEHEM

ORG_NAME: LEHIGH UNIVERSITY

PHR: Aggression varies substantially between different people, and extreme levels of aggression have negative consequences for individuals and society. This proposal will leverage genetic tools and resources in an emerging model system to investigate the genetic and neuronal basis of variability in aggression. Elucidating the genetic architecture underlying differences in aggression in natural populations will help establish why individual differences in social behaviors manifest, which could lead to long term solutions for treatment and management.

PI_NAMEs: KOWALKO, JOHANNA E. (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Aggressive behavior;base;Behavior;Behavioral;Biological Models;blind;Candidate Disease Gene;Chromosome Mapping;Complex;Evolution;Fishes;Genetic;genetic architecture;genetic variant;Genetic Variation;genome resource;Goals;Human;Individual;Individual Differences;insight;Laboratories;Methods;Mexican;model organism;Molecular;Morphology;Natural Selections;neuromechanism;Neurons;Organism;Persons;Physiological;Population;programs;Research;Resources;Role;Social Behavior;Societies;Surface;System;Testing;tool;trait

PROJECT_TITLE: Evolutionary approaches to identify genetic architecture regulating aggression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PUBLIC HEALTH RELEVANCE Maternal mental illness can adversely modify the developmental trajectory of the child and is a significant contributor to maternal mortality in the U.S. A significant portion of women can experience traumatic childbirth, and some will develop posttraumatic stress disorder (PTSD), although this condition remains underdiagnosed and undertreated. This study will define the course and predictors of maternal childbirth-related PTSD and its effects on the child and lay the foundation for preventive and holistic care for both mother and child.

PI_NAMEs: DEKEL, SHARON  (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: Accidents;Address;Affect;American;American College of Obstetricians and Gynecologists;Animal Model;antenatal;assault;Behavioral;Biological;Biological Markers;Birth;Breast Feeding;candidate identification;Caring;Child;Child Development;Child Welfare;Childbirth;Chronic;Clinical;Cognition;Cognitive;cohort;combat;Communication;cost;Data;Development;Diagnosis;Dimensions;Discipline of obstetrics;Disease;DSM-V;Early Intervention;early screening;Emotional;emotional distress;Enhancers;Epigenetic Process;ethnic health disparity;Ethnic Origin;experience;Exposure to;Foundations;Goals;Growth;Health;health disparity;Hour;Imagery;Impairment;improved;Infant;infant temperament;insight;intergenerational;Investigation;Knowledge;Knowledge acquisition;Life;longitudinal, prospective study;low socioeconomic status;Maternal Deprivation;Maternal Health;maternal morbidity;Maternal Mortality;Measurement;Measures;Mediating;Medical;Medical Records;Mental Depression;Mental disorders;Mental Health;Mental Health Services;mental imagery;Military Personnel;Minority Women;Mission;Modification;Morbidity - disease rate;Mother-Child Relations;Mothers;Motor;National Institute of Child Health and Human Development;neonatal period;Neurotic Disorders;obstetrical complication;Outcome;patient stratification;Perception;Perinatal;Physiological;Post-Traumatic Stress Disorders;Postpartum Depression;Postpartum Period;Pregnancy;Pregnant Women;prepregnancy;prevent;Preventive;Procedures;Productivity;programs;prospective;protective factors;Provider;Psyche structure;psychologic;Psychometrics;Psychopathology;Psychophysiology;public health relevance;Quality of Care;racial discrimination;racial health disparity;Recommendation;Reduce health disparities;Reproductive Process;response;Risk;Risk Factors;Role;Schedule;screening;Security;social determinants;Social support;societal costs;Standardization;stem;Stress;stressor;Symptoms;Testing;Therapeutic Intervention;Third Pregnancy Trimester;Time;tool;Trauma;trauma exposure;traumatic event;traumatic stress;Validation;welfare;Well in self;Woman;Work

PROJECT_TITLE: Defining postpartum PTSD and its implications for maternal wellness and child development

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Urologic Diseases

PI_NAMEs: HULTGREN, SCOTT J. (contact)

PROJECT_TERMS: Acinetobacter;Acute;Adhesives;Affinity;antagonist;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;Antibodies;Antibody Therapy;Bacteria;Bacterial Adhesins;Bacterial Antibiotic Resistance;bacterial community;Bacterial Infections;Basic Science;Binding;Biological Availability;Bladder;cancer therapy;candidate identification;carbapenem-resistant Enterobacteriaceae;catheter associated UTI;Catheters;Cell Wall;Cells;Chronic;Chronic Cystitis;Climate;Clinical Treatment;Clinical Trials;Collaborations;combat;Communicable Diseases;community-acquired UTI;COVID-19;design;Development;diabetic;Disease;drug discovery;drug resistant pathogen;Enterobacteriaceae;Enterococcus;Enterococcus faecalis;experimental study;Extended-spectrum β-lactamase;extracellular;Fibrinogen;Funding;Galactose;gastrointestinal;Gastrointestinal tract structure;global health;glycomimetics;Gram-Negative Bacteria;gut colonization;Habitats;Health;Healthcare;host colonization;Human;implant coating;implantation;In Vitro;in vivo;Indwelling Catheter;Infection;Inflammatory;Ingestion;innovation;Invaded;Kidney;Klebsiella;Klebsiella pneumoniae;Knowledge;Life;life span;Ligands;Mannose;Mannosides;Medicine;Microbial Biofilms;mimetics;Modeling;Molecular Chaperones;Monoclonal Antibodies;mouse model;multi-drug resistant pathogen;Multidrug-resistant Acinetobacter;Neurons;Nosocomial Infections;Oral;pathogen;Pathogenicity;Pathway interactions;Pectins;Permeability;Phase;Phase Ia/Ib Clinical Trial;Pilum;Plants;Pre-Clinical Model;pressure;prevent;Privatization;programs;receptor;Recurrence;residence;Resistance;resistance mechanism;Resistance profile;Resources;small molecule;sortase;Structure-Activity Relationship;success;Surface;Testing;Therapeutic;Therapeutic Monoclonal Antibodies;Tissues;Translating;United States;urgent and serious threat;Urinary tract infection;Uropathogen;Uropathogenic E. coli;Vaccines;Vancomycin Resistance;Vancomycin resistant enterococcus;Work;wound

PROJECT_TITLE: Development of anti-adhesin mAbs and high-affinity ligand mimetics to treat and prevent UTIs


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PHR: PROJECT NARRATIVE There is an unmet need in the HIV vaccine field for immunogens that consistently elicit potent and broad neutralizing antibodies. We have demonstrated that HIV-1 fusion peptide prime and Env boost is a promising strategy and will test novel immunogens and immunization strategies to improve the breadth, magnitude, and quality of the fusion peptide-directed neutralizing responses.

PI_NAMEs: KONG, RUI  (contact)

PROJECT_TERMS: Address;Amino Acids;Animals;Antibodies;Antibody Response;Antigens;B-Lymphocytes;Binding;Carrier Proteins;Cavia;Cells;Chikungunya virus;Circulation;cross reactivity;Data;design;Epitopes;Evaluation;Frequencies;Future;Heterogeneity;HIV vaccine;HIV-1;Human;Immunization;Immunize;immunogenic;improved;In Vitro;Individual;Keyhole Limpet Hemocyanin;Link;Modification;Monoclonal Antibodies;Mus;N-terminal;neutralizing antibody;nonhuman primate;novel;peptide vaccination;Peptides;Phase II Clinical Trials;Plasma;polyclonal antibody;Polysaccharides;protein aminoacid sequence;Reproducibility;Research Design;response;Science;Serum;Site;Structure;Testing;vaccination strategy;Vaccine Design;Variant;Venezuelan;Venezuelan Equine Encephalitis Virus;Virus;Virus-like particle;Western Equine Encephalitis Virus

PROJECT_TITLE: HIV-1 Fusion Peptide-directed Vaccine Design Using Virus-like Particles

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ORG_CITY: GREENVILLE

ORG_NAME: EAST CAROLINA UNIVERSITY

PHR: Secondary lymphoid organs are a major site for HIV-1 spread and harbor viral reservoirs, which are a barrier to curing AIDS. The proposed project in this application addresses the questions how HIV-1 disseminates in secondary lymphoid organs and how viral reservoirs are generated in these organs. The outcomes of the proposed studies may contribute to developing a new strategy to prevent HIV-1 infection.

PI_NAMEs: MURAKAMI, TOMOYUKI  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;antiretroviral therapy;Architecture;B-Lymphocytes;CD4 Positive T Lymphocytes;CD44 gene;cell motility;Cell Separation;Cells;chemokine;Coculture Techniques;cytokine;Development;enhancing factor;Environment;experimental study;Follicular Dendritic Cells;Goals;Helper-Inducer T-Lymphocyte;HIV;HIV Infections;HIV-1;HIV/AIDS;Human;Hyaluronan;in vivo;Infection;Investigation;latent infection;Ligands;lymph nodes;Lymphocyte;Macaca mulatta;Mediating;Memory;Organ;Outcome;Outcome Study;Pathogenesis;Patients;permissiveness;Play;Polysaccharides;Predisposition;prevent;Prevention strategy;Process;Productivity;Proliferating;Property;Proteins;Research;Rest;Reticular Cell;Rhesus;Role;secondary lymphoid organ;Site;SIV;Source;Study models;System;T-Lymphocyte;Testing;transcriptome;transcriptome sequencing;Viral reservoir;Virion;virtual;Virus Latency;Work

PROJECT_TITLE: The Roles of FRCs In HIV-1 Spread And Establishment Of Latency

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-E(02)]


ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

PHR: Natural killer (NK) cells play a key role in early control of HIV infection and we have recently uncovered that in people living with HIV, a subset of memory NK cells can specifically recognize and efficiently eliminate cells presenting peptide antigens derived from HIV. This proposal is designed to comprehensively determine the mechanisms regulating the development and function of memory NK cells with potent anti-viral activity. The outcome of these investigations will provide the rationale to harness memory NK cells for vaccine design, curative or other therapeutic interventions against HIV.

PI_NAMEs: JOST, STEPHANIE ;REEVES, ROGER KEITH (contact)

PROJECT_TERMS: Address;Antibodies;Antibody-Dependent Enhancement;Antigens;Autologous;B-Lymphocytes;Binding;Cell Line;Cell Physiology;Cells;Clonal Expansion;Cytomegalovirus;Cytotoxic T-Lymphocytes;Data;design;Development;Disparate;Effector Cell;Epigenetic Process;Epitopes;Exhibits;Exposure to;Future;Gene Expression Profile;Genetic Transcription;Helper-Inducer T-Lymphocyte;HIV;HIV Antigens;HIV Infections;HIV vaccine;Hour;Human;Immune;immune function;In Vitro;in vivo;Infection;Infectious Agent;Influenza;Innate Immune System;interest;Investigation;Kinetics;KLRD1 gene;Laboratories;Ligands;Mediating;Memory;Metabolic;Molecular;Molecular Profiling;mouse model;Mus;Natural Killer Cells;nonhuman primate;Outcome;Pathway interactions;Peptides;Persons;Play;prevent;Primates;programs;protective effect;receptor;Reporting;response;Role;Sampling;sensitizing antigen;single-cell RNA sequencing;SIV;Specificity;T-Lymphocyte;Therapeutic Intervention;Vaccination;Vaccine Design;Viral;Viral Physiology;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Fine Mechanisms of Adaptive NK Cell Formation Against HIV and SIV


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Exosomes are nano-sized vesicles produced by all cells in both physiological and pathological states that play a vital role in multiple biological processes including cell-cell communication, immune regulation, tissue development and regeneration, and cancer metastasis. Exosomes represent excellent candidates for the development of new diagnostic and therapeutic tools, yet the mechanism controlling their biogenesis is poorly understood. In this Project, we will study the role of long non-coding RNA (a novel class of gene expression regulators) on exosome biogenesis, thereby advancing our understanding of these mechanisms and providing the basis for the use of exosomes as novel biomarkers and the development of new therapeutics.

PI_NAMEs: MOMEN HERAVI, FATEMEH  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Biogenesis;Biological Process;Biology;carcinogenesis;Cell Communication;Cell membrane;Cell Physiology;Cells;Cellular Stress;Code;Cytoplasm;Data;Development;Diagnostic;Disease;disease diagnosis;Docking;Exhibits;exosome;extracellular;Gene Expression;Genes;HIF1A gene;Hypoxia;immune function;immunoregulation;improved;interest;late endosome;macromolecule;MAP Kinase Gene;Mediating;Multivesicular Body;nanosized;Natural regeneration;Neoplasm Metastasis;novel;novel diagnostics;novel marker;novel therapeutics;Nuclear;Nucleic Acids;Organogenesis;Oxidative Stress;Pathologic;Pathway interactions;Physiological;Play;Process;Production;Proteins;Regulation;Regulator Genes;Research;RNA;Role;Signal Pathway;Sorting;stem cell differentiation;Stress;Therapeutic;Therapeutic Uses;tissue regeneration;Tissues;tool;trafficking;Untranslated RNA;Vesicle;Virus Replication

PROJECT_TITLE: Role of Long Non-Coding RNAs in Exosome Biogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE: Environmental or occupational exposures to hexavalent chromium Cr(VI) have been associated with a number of adverse health effects; yet, little is known about its impact on skeletal muscles. This proposal aims to investigate the effect of Cr(VI) exposure on myogenic differentiation and muscle regeneration. The success of the proposed research will generate valuable evidence to support Cr(VI) exposure as a risk factor for muscle impairment, and provide additional insights on prevention and therapeutic approaches for muscle-associated disease.

PI_NAMEs: SUN, HONG  (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Acute;Address;Adult;Adverse effects;Affect;Animals;AT Rich Sequence;Binding Proteins;Carcinogens;Cardiovascular system;cell type;Cells;Chromatin;chromium hexavalent ion;Chronic;comparison control;Control Groups;Coturnix japonica;Creatine Kinase;Defect;differentiation in vitro;Direct Lytic Factors;Disease;Dose;drinking water;Electroplating;Embryo;Embryonic Development;Environmental Exposure;Exposure to;Female;Fiber;gastrointestinal;Gene Expression;Genes;Health;Hematology;Hepatic;Human;human study;human subject;Impairment;In Vitro;in vivo;in vivo regeneration;Industrialization;Injury;insight;Intramuscular Injections;Lead;leather tanning;Lifting;lung carcinogenesis;male;manufacture;Mediating;Mediator;meter;Movement;Mus;Muscle;Muscle Development;Muscle Fibers;Muscle function;muscle regeneration;Muscle satellite cell;Musculoskeletal System;Myoblasts;myogenesis;Myogenic Regulatory Factors;National Toxicology Program;Natural regeneration;Occupational Exposure;Oral Ingestion;Pathway interactions;Pattern;Pigments;prenatal;prenatal exposure;preservation;Prevention;Process;Production;Proliferating;Rattus;repaired;Reporting;Research;respiratory;Risk Factors;Rodent;Role;Serum;Skeletal Muscle;skeletal muscle differentiation;Skeletal muscle injury;Stainless Steel;stem cell population;stem cells;stemness;success;System;Textiles;Therapeutic;Toxic effect;transcriptome sequencing;transcriptomic profiling;Trauma;Wood material

PROJECT_TITLE: Cr(VI) exposure and skeletal muscle differentiation and regeneration

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Contraception/Reproduction;Endocrine Disruptors;Fibroid Tumors (Uterine);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: Uterine leiomyomas (UL), also known as fibroids, are the leading cause of hysterectomy in the United States. These benign tumors, which are more common among Black individuals, can cause heavy menstrual bleeding, pelvic pain, and infertility. This project will examine the age distribution of when UL occur, the extent to which UL characteristics (size, number, location) predict symptom severity, and environmental factors associated with UL occurrence and growth in a cohort of Black individuals during a 15-year period.

PI_NAMEs: MARSH, ERICA E;WEGIENKA, GANESA REBECCA (contact);WISE, LAUREN A

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Affect;African American Women;Age;Age Distribution;aged;Anemia;Area;Benign;Biological;Biological Assay;Biological Markers;Black Populations;Black race;black women;Blood;Blood specimen;Characteristics;Chemicals;Clinic Visits;clinical care;cohort;Cohort Studies;cost;Data;Data Collection;Detection;Diagnosis;Disproportionately impacts women;Endocrine system;Enrollment;Environment;environmental chemical;Environmental Risk Factor;Estrogens;Etiology;experience;Exposure to;Female;Fibroid Tumor;flexibility;follow-up;Funding;Goals;Gonadal Steroid Hormones;Grant;Growth;Growth and Development function;Health;Health Policy;Heavy Metals;Hemorrhage;Hormones;Human;Hysterectomy;Incidence;Infertility;Interdisciplinary Study;Interview;Journals;Life Style;lifetime risk;Literature;Location;low socioeconomic status;Maps;Measures;member;Menorrhagia;metabolomics;Minority;myometrium;National Institute of Environmental Health Sciences;Natural History;Neoplasms;novel;Operative Surgical Procedures;Participant;Patients;Peer Review;Pelvic Pain;Persons;Phenols;phthalates;Poly-fluoroalkyl substances;Polychlorinated Biphenyls;Population;Pregnancy Complications;Productivity;Progesterone;prospective;Prospective Studies;Public Health;Publications;Quality of life;Questionnaires;receptor binding;Reporting;reproductive;Research;Research Design;Resources;Risk Factors;Sampling;Sampling Studies;Science;Severities;Severity of illness;Sex Behavior;study population;Symptoms;Time;toxicant;Transvaginal Ultrasound;tumor;ultrasound;United States;United States National Institutes of Health;Urine;Uterine Fibroids;Uterine Neoplasms;Visit;White Women;Work

PROJECT_TITLE: Environmental risk factors for uterine fibroids: a prospective ultrasound study

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: Narrative T cells are a class of immune cells that fight diseases and cancer, whereas regulatory T cells (Tregs) are an opposing class that are essential to prevent autoimmune disease and rejection of organ or bone marrow transplants. Our project aims to understand how DNA methylation and demethylation affect T cell expansion and regulatory T cell function. This may give us new methods for improving how T cells and regulatory T cells function in the body to improve the efficacy of patient treatment.

PI_NAMEs: RAO, ANJANA  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Adoptive Transfer;Affect;Aging;alpha ketoglutarate;Aneuploidy;Antigens;Architecture;Autoimmune;Autoimmune Diseases;Biochemical;Bone Marrow;Bone Marrow Transplantation;cancer cell;Cardiovascular Diseases;CD19 gene;CD4 Positive T Lymphocytes;Cell Culture System;Cell Lineage;Cell Physiology;cell type;Cells;Chimera organism;Chromosomal Instability;Chromosome 17;chromosome missegregation;congenic;cytokine;Cytosine;Data;demethylation;Development;Dioxygenases;Disease;DNA;DNA Damage;DNA Methylation;DNA Modification Methylases;DNA Structure;DNA Transposable Elements;Enhancers;Enterobacteria phage P1 Cre recombinase;Enzymes;experimental study;Female;fighting;FOXP3 gene;Functional disorder;G-Quartets;Genes;Genome;genome-wide;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Heterochromatin;Heterozygote;Histones;Human;IL17 gene;Immune;Immunocompetent;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;innate immune sensing;Interferon Type I;Interferons;Interleukin-6;Iron;Link;LoxP-flanked allele;Lymphocytic Infiltrate;Lysine;Malignant Neoplasms;Methods;methyl group;Methylation;methylation pattern;micronucleus;Molecular;Mouse Strains;Mus;Mutant Strains Mice;Mutation;Myelogenous;Neurodegenerative Disorders;Older Population;Oncogenic;Organ;organ transplant rejection;Outcome;Oxygen;Paper;Pathway interactions;Patients;Penetrance;Phenotype;premalignant;prevent;promoter;Proteins;Recurrence;Regulatory T-Lymphocyte;Repetitive Sequence;Reporting;response;RNA;Role;Signal Transduction;Solid;Specific qualifier value;stem;Sterility;Structure;Syndrome;System;systemic inflammatory response;Systemic Lupus Erythematosus;T-Cell Receptor;T-Lymphocyte;Testing;Tetanus Helper Peptide;Trisomy 17;Up-Regulation;whole genome;X Chromosome;X Inactivation

PROJECT_TITLE: Investigating the role of TET deficiency in promoting T cell expansion and inflammation

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Immunotherapy;Regenerative Medicine;Wound Healing and Care

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Immunosuppression is a major risk factor for non-healing wounds, indicating that signals derived from immune cells are necessary for optimal repair. Yet, exactly how lymphocytes are activated in wounds and their molecular dialogue with injured epithelium is ill defined. The goal of this proposal is to understand how type 17 immune cells are activated in response to injury and elucidate their mechanistic crosstalk with the epithelium.

PI_NAMEs: NAIK, SHRUTI  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Ablation;Activated Lymphocyte;Address;Affect;Animals;Autoimmune;Binding;Cancerous;Cell Hypoxia;cell type;Cells;Chronic;chronic wound;Communication;cost estimate;Coupling;cytokine;Cytokine Signaling;cytotoxic;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;Dermal;differential expression;Epithelial Cells;epithelial injury;epithelial stem cell;epithelial wound;Epithelium;Failure;Genetic Transcription;Goals;healing;Health;Hypoxia;hypoxia inducible factor 1;IL17 gene;Immune;Immunity;Immunocompetent;Immunologist;Immunosuppression;Immunotherapy;Impaired wound healing;Impairment;in vivo;Inflammation;Inflammatory;injured;Injury;innovation;insight;Interleukin Receptor;Interleukins;Intervention;Knowledge;Lymphocyte;Lymphoid Cell;Malignant Neoplasms;Maps;Measures;Mediating;Memory;microbial;migration;Molecular;Molecular Target;mouse genetics;Mucous Membrane;Mus;new therapeutic target;non-healing wounds;novel;pathogen;Pathology;Pathway interactions;Population;Positioning Attribute;Predisposing Factor;Production;programs;Proteins;prototype;re-epithelialization;receptor;recruit;Regulatory T-Lymphocyte;repaired;Resolution;response;response to injury;Risk Factors;Role;Science;Signal Induction;Signal Transduction;Site;Skin;Specialist;T-Cell Receptor;T-Lymphocyte;Techniques;Technology;Testing;therapeutic target;Thromboplastin;Time;tissue repair;Tissues;transcription factor;transcriptomics;wound;wound healing;γδ T cells

PROJECT_TITLE: Mechanisms of immune-epithelial crosstalk in tissue repair

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Genomic research offers a unique opportunity for rare disease diagnosis and understanding that may be transformative for people living with these complex conditions, however, access to these opportunities is inequitably distributed. With this project, we take an implementation science approach to the development and evaluation of a toolkit to improve diversity, equity, and inclusion in rare disease genomic research via a novel initiative within the Rare Genomes Project (Aim 1); evaluate the effectiveness and impact of research genome sequencing for diverse populations by identifying genetic diagnoses for historically underserved and minoritized communities (Aim 2); and explore the priorities and values of diverse populations with rare diseases undergoing research sequencing within a large consortium (Aim 3). The findings from this research will inform both research and clinical applications of genome sequencing with the ultimate goal of advancing equity for individuals and families with rare disease.

PI_NAMEs: WOJCIK, MONICA HSIUNG (contact)

PROGRAM_OFFICER_NAME: CHANG, CHRISTINE Q

PROJECT_TERMS: Address;Adoption;Area;Attention;Characteristics;Clinic;Clinical;clinical application;clinical implementation;clinical practice;cohort;community engagement;Complex;Data;demographics;design;Development;Diagnosis;Diagnostic;Dimensions;disease diagnosis;Effectiveness;effectiveness evaluation;effectiveness research;effectiveness/implementation design;effectiveness/implementation study;empowerment;Enrollment;Environment;Equity;equity, diversity, and inclusion;Evaluation;Family;Future;Genetic Diseases;genetic disorder diagnosis;Genetic Services;Genome;genome analysis;genome sequencing;Genomic medicine;Genomics;Goals;Health;health disparity;Healthcare;Healthcare Systems;Hour;Hybrids;implementation fidelity;implementation outcomes;implementation science;Improve Access;improved;Individual;Inequity;informant;insight;Interview;Knowledge;Limited English Proficiency;Logistics;Maintenance;Medical Genetics;Methods;Minority;minority communities;Minority Enrollment;Minority Groups;Mission;Molecular Diagnosis;Molecular Genetics;Morbidity - disease rate;mortality;nonEnglish language;novel;Outcome;Participant;patient engagement;patient oriented;Patient-Focused Outcomes;personalized approach;Persons;Pilot Projects;Policies;Population;Population Heterogeneity;portability;Precision therapeutics;Procedures;Process;Provider;Public Health;Quality of life;Rare Diseases;rare genetic disorder;rare mendelian disorder;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;remote consent;Research;Research Design;Research Personnel;research study;Resources;Sampling;Services;social;social capital;Surveys;Underrepresented Populations;underserved community;Underserved Population;United States;United States National Institutes of Health;Venous blood sampling

PROJECT_TITLE: Advancing Equity in Rare Disease Genomics


ADMINISTERING_IC: DA

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE The diversity, population size, and health challenges of metropolitan Houston provides an ideal setting for a new NIDA R25: Providing Research Education Experiences to Enhance Diversity in the Next Generation of Substance Abuse and Addiction Scientists. The University of Houston (UH) will leverage its Helping Everyone Achieve a LifeTime of Health (HEALTH) Research Institute and NIMHD RCMI (HEALTH Center for Addictions Research and Cancer Prevention) to serve as the platform for executing an innovative substance abuse research education program to the future generation of scientists underrepresented in the biomedical, behavioral, clinical, and social sciences. The HEALTH – Future Addiction Scientist Training (HEALTH – FAST) Program will leverage a transdisciplinary approach to health-equity science with a focus on how substance use/abuse leads to chronic diseases that disproportionately affect health-disparity populations.

PI_NAMEs: OBASI, EZEMENARI M;REITZEL, LORRAINE R (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, YOHANSA

PROJECT_TERMS: Acceleration;addiction;Address;Affect;alcohol tobacco and other drug use;Applications Grants;Area;Asian;Asian Americans;ATOD;Behavior;Behavioral Sciences;Biochemistry;Biology;Biomedical Engineering;Black race;cancer prevention;career;Career Mobility;Chronic Disease;Clinical Sciences;college;Communities;comorbidity;Computers;Data;Degree program;design;Development;Development Plans;disadvantaged background;disease disparity;Disparity;Disparity population;Education;education research;Educational Curriculum;Educational Status;Engineering;Enrollment;Ensure;ethnic diversity;ethnic minority;Event;Evidence based intervention;experience;Faculty;faculty mentor;Feedback;Funding;Future;Future Generations;Grant;Health;health disparity;health disparity populations;health equity;health science research;Health Sciences;Health system;Hispanic-serving Institution;Human;improved;Individual;innovation;Institution;Interdisciplinary Study;Investments;Journals;Knowledge;Latinx;Learning;Location;Manuscripts;Maps;matriculation;Medical center;meetings;Mentors;metropolitan;Modification;National Institute of Drug Abuse;National Institute on Minority Health and Health Disparities;Native Americans;next generation;novel;Outcome;Pacific Island Americans;Peer Review;Performance;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Policies;Population;population health;Population Sizes;Postdoctoral Fellow;Preparation;Process;Productivity;Program Evaluation;Program Reviews;programs;protective factors;psychologic;Psychology;Public Health;Publications;Qualifying;racial minority;Research;Research Activity;research faculty;Research Institute;Research Personnel;Research Training;Resources;responsible research conduct;Risk;Science;Scientist;Secure;Series;skills;Social Sciences;Social Work;Substance abuse problem;Substance Addiction;substance use;substance use prevention;Texas;Time;trafficking;Training;Training and Education;Training Programs;trend;Underrepresented Populations;Universities;vulnerable community;Woman;Work;Writing

PROJECT_TITLE: Helping Everyone Achieve a LifeTime of Health - Future Addiction Scientist Training


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_CITY: Princeton

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative  Gender diverse children often experience disparities in mental health and well-being. Further questions concern the stability of their gender as that has implications for medical transitions. The proposed work would examine the role of gender beliefs and self-categorization in predicting mental health and well-being, as well as provide better estimates of rates of stability and change across time in the identities of both cisgender and gender diverse youth.

PI_NAMEs: OLSON, KRISTINA  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Adolescence;Adolescent;Adult;Age;Belief;Categories;Child;cisgender;Clinical Psychology;Cognition;cognitive development;cognitive process;cohort;Communication;Congresses;Development;Disparity;Environmental Exposure;Event;experience;Exposure to;flexibility;Gender;gender diverse;gender diversity;gender fluid;Gender Identity;Grant;Health;health disparity;Human;Human Development;Individual;Individual Differences;Influentials;Laws;Learning;Life;life span;Link;Liquid substance;Longitudinal Studies;Measures;Medical;Mental Health;nonbinary;Parents;Participant;Perception;Personal Satisfaction;Persons;Procedures;Process;Recontacts;recruit;Research;Role;Sampling;Sampling Studies;Schools;social;social cognition;Social Development;Social Environment;Societies;Stereotyping;Testing;theories;Time;transgender;Update;Variant;Work;Youth

PROJECT_TITLE: Views of Gender in Adolescence

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Lymphatic Research;Lymphedema;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

PHR: PROJECT NARRATIVE Dysfunction of lymphatic vessels can lead to lymphedema and no-healing ulcers, affecting over 250 million people worldwide. Here I propose to examine the role of repair and immune-modulatory functions of lymphatic vessels in the control of wound repair to further our understanding of the cellular and molecular factors that underlie this complex process. My studies will uncover novel targets aimed at modulating lymphatic vessels, immune cells, and epidermal stem cells to advance therapeutic approaches in pathological tissue repair.

PI_NAMEs: KONIECZNY, PIOTR  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Address;Affect;Behavior;Biology;Blood;Blood capillaries;career;career development;Cells;Chronic;chronic ulcer;chronic wound;Clinical;Communication;Complement Factor D;Complex;cytokine;Data;Dermal;Dermis;Development Plans;Drainage procedure;epidermal stem cell;Epidermis;epithelial repair;epithelial wound;Epithelium;experimental study;Fibroblasts;Fibrosis;fluid flow;Foundations;Future;Gene Expression;Genomics;Grant;Growth;Growth Factor;Hair follicle structure;healing;Human body;Image;Immune;immune cell infiltrate;immune function;Immune response;Immunologic Surveillance;immunoregulation;Impaired healing;improved;Inflammation;Injury;innovation;Intercellular Fluid;interstitial;Knowledge;Link;Liquid substance;Lymph;Lymphangiogenesis;Lymphatic;lymphatic circulation;lymphatic drainage;lymphatic dysfunction;Lymphatic function;Lymphatic System;lymphatic vessel;Lymphedema;Macrophage;Mediating;Medical;Mentors;Modeling;Molecular;morphogens;mouse model;multidisciplinary;Mus;Natural regeneration;non-healing wounds;novel;novel therapeutics;Pathologic;Patients;Peptides;Persons;Phase;Physiological;Physiology;Positioning Attribute;pressure;Prevalence;Process;Production;Productivity;programs;Proteins;re-epithelialization;recruit;regeneration function;Regulation;repaired;Research;research and development;Research Personnel;response;restoration;Role;single-cell RNA sequencing;Skin;Skin repair;skin wound;Source;stem cells;Swelling;Technology;Testing;Therapeutic;tissue repair;Tissues;tool;Ulcer;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factor D;Vascular System;wound;wound closure;wound healing;wound treatment;Writing

PROJECT_TITLE: Decoding the repair and immunomodulatory functions of lymphatic vessels in wound healing

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PI_NAMEs: DESILVA, ARAVINDA M. (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TITLE: PROJECT 2: Linking Vaccine-Induced Antibody Responses to Protective or Disease Enhancing Immunity


PI_NAMEs: WEISKOPF, DANIELA  (contact)

PROJECT_TITLE: PROJECT 3: Quality of T Cell Responses Following DENV Natural Infections and Live-Attenuated Dengue Virus Vaccination


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Chronic Pain;Dementia;Genetics;Natural Products;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE  Neuropathic pain is a serious and long-term neurotoxic side effect of chemotherapy affecting more than 68% of cancer patients and is currently without treatment. Peripheral neuropathy and pain have also been associated with Alzheimer’s. Our studies on sensory neuronal maintenance have found NMNAT proteins to be among the most robust and versatile neuroprotective factors known and have the potential to mitigate sensory dysfunction. The proposed studies will employ innovative technologies to discover microRNA and neutral compound-based neuroprotective strategies to enhance NMNAT-mediated therapeutic treatments for neuropathic pain in the context of chemotherapy induced peripheral neuropathy and Alzheimer’s disease.

PI_NAMEs: ZHAI, RONG GRACE (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Administrative Supplement;Affect;Afferent Neurons;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;arm;Award;Behavior;Behavioral;behavioral study;Cancer Patient;Cellular biology;cellular pathology;chemotherapy;Chemotherapy-induced peripheral neuropathy;chronic pain;Clinical;cognitive performance;Cultured Cells;Data Science;Dementia;Development;Dose Limiting;Drosophila genus;efficacy evaluation;Environment;Enzymes;experience;Functional disorder;gain of function;Genetic;Genetic Models;Genetic Transcription;Glutamate-ammonia-ligase adenylyltransferase;Grant;Homeostasis;hyperphosphorylated tau;Hypersensitivity;Impairment;in vivo;in vivo Model;innovation;innovative technologies;Larva;Lead;loss of function mutation;Maintenance;MAPT gene;Mediating;MicroRNAs;Microtubules;Modeling;Molecular;Morphology;mRNA Expression;mRNA Precursor;mRNA Stability;mutant;Natural Compound;Nerve Degeneration;Nervous System Physiology;neural;Neurons;Neuropathy;neuroprotection;neurotoxic;Nicotinamide Mononucleotide;Nociception;Nociceptors;novel therapeutics;opioid use;Outcome;Pain;pain behavior;pain model;painful neuropathy;parent project;Parents;Pathology;Pathway interactions;Patients;Peripheral Nervous System Diseases;peripheral pain;Pharmaceutical Preparations;Pharmacology;Phenotype;Physiological;Population;programs;Proteins;recreational drug use;Regulation;Reporting;Resort;response;RNA Splicing;Role;screening;Sensory;Severities;side effect;Symptoms;Tauopathies;Testing;Therapeutic;Therapeutic Agents;therapeutic miRNA;tool;United States National Institutes of Health;Variant;whole health;Work

PROJECT_TITLE: microRNA regulation of NMNAT-mediated Neuroprotection against Peripheral Neuropathy and Chronic Pain


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The Molecular Transducers of Physical Activity Consortium (MoTrPAC) examines the biological response to exercise using state of the art tools across thousands of humans and in animal models. The Stanford MoTrPAC Bioinformatics Center provides core compute, storage and analytic expertise to the MoTrPAC investigators. The MoTrPAC Bioinformatic Center will collaborate with the Common Fund Data Ecosystem to enhance the usability and interconnectedness of MoTrPAC and other Common Fund data.

PI_NAMEs: ASHLEY, EUAN A (contact);WHEELER, MATTHEW THOMAS

PROGRAM_OFFICER_NAME: PAPANICOLAOU, GEORGE

PROJECT_TERMS: Acute;Address;Administrative Supplement;analysis pipeline;Animal Model;Binding;Bioinformatics;Biological;Biology;Catalogs;Chronic;Collaborations;Communities;Data;data ecosystem;data harmonization;data modeling;data resource;Data Set;data standards;Disease;empowerment;Exercise;experience;Funding;Generations;Goals;Health;Human;improved;innovation;insight;Intervention;Mission;Molecular;multiple omics;novel;outreach;Phenotype;Physical activity;Physical Exercise;Recording of previous events;Reproducibility;Research;Research Personnel;Research Training;Resources;response;Tissues;tool;Training;transcriptomics;Transducers;usability;Validation

PROJECT_TITLE: Stanford MoTrPAC Bioinformatics Center - CFDE


ORG_CITY: SEATTLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The proper three-dimensional organization of DNA within the nucleus is critically important for healthy cells, and alterations to organization are associated with developmental disease and cancer. This research program aims to better characterize the patterns of DNA organization that occur in healthy cells and to investigate how these impact important cellular processes such as gene expression, DNA replication, and DNA repair. A more complete understanding of how 3D genome organization functions within the cell will provide key insights into why this process is associated with human disease and may inform new therapeutic strategies.

PI_NAMEs: BELIVEAU, BRIAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 3-Dimensional;Address;Architecture;Bioinformatics;biophysical properties;Biophysics;cell fixing;Cell Nucleus;Cell Physiology;Cells;cellular imaging;Chromosome Mapping;Chromosome Structures;Chromosomes;Complex;cost;Data Set;design;Development;developmental disease;Diameter;DNA;DNA biosynthesis;DNA Repair;Environment;Fluorescent in Situ Hybridization;Frequencies;Gene Expression;Genetic Transcription;Genome;genome-wide;Genomics;Hi-C;human disease;Imaging technology;Individual;insight;live cell imaging;Malignant Neoplasms;Mammalian Cell;meter;Methods;Microscopy;nanoscale;novel therapeutic intervention;Nuclear;Oligonucleotide Probes;Optics;Pattern;physical property;Population;Process;programs;Proteins;repaired;Research;Resources;Sampling;screening;Signal Transduction;single molecule;Structure;superresolution microscopy;Techniques;Technology;Tissues;Trans-Activators;Visual;Work

PROJECT_TITLE: Probing the dynamics of chromosome organization in single cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nanotechnology;Substance Misuse

ORG_CITY: TOLEDO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

PHR: PROJECT NARRATIVE Activation of multiple signaling pathways is a hallmark of alcohol-associated liver disease (AALD) with no approved treatment available. In the current study, we will utilize dual inhibition of AKT/BRD4 by SF2523 and Hh pathway by MDB5 formulated in cleavable nanoparticles to inhibit AALD progression.

PI_NAMEs: KUMAR, VIRENDER  (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Abbreviations;Acetaldehyde;AKT inhibition;alcohol abstinence;Alcohol abuse;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Area;Award;Binding;Biodistribution;Blood;c-myc Genes;career;career development;Cell Survival;cell transformation;Cells;Cessation of life;chronic liver injury;Cirrhosis;Collaborations;Communication;conventional therapy;Credentialing;CYP2E1 gene;cytokine;Data;Deposition;Development;Diagnosis;Diet;dietary control;Disease;Disease Progression;Disease regression;DNA Damage;Drug Delivery Systems;Drug Kinetics;Encapsulated;Environment;Erinaceidae;Ethanol;experience;Extracellular Matrix;Faculty;Fatty acid glycerol esters;Fatty Acids;fibroblast activation protein alpha;fibroblast-activating factor;Fibroblasts;Fibrosis;Funding;Gene Family;Genes;GLI gene;Goals;Grant;Hepatic Stellate Cell;Hepatocyte;HMGB1 gene;Human;Hydrophobicity;Immune response;In Vitro;in vivo;Industry;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;inhibitor;innovation;kidney fibrosis;Knowledge;Kupffer Cells;Leadership;Leaky Gut;Ligands;Lipid Peroxidation;Lipids;Lipopolysaccharides;Liver;Liver diseases;Liver Fibrosis;liver inflammation;liver injury;liver transplantation;Malignant neoplasm of pancreas;Mediating;member;Mentors;Morbidity - disease rate;multidisciplinary;Mus;nanocarrier;nanomedicine;nanoparticle;Nature;Necrosis;new therapeutic target;next generation;NF-kappa B;novel;novel therapeutics;overexpression;Pathogenesis;Pathway interactions;Patients;peptide amphiphiles;Peptide Hydrolases;Peptides;Pharmaceutical Preparations;PI3K/AKT;PIK3CG gene;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor beta Receptor;prevent;Production;Productivity;protein expression;Protein-Serine-Threonine Kinases;Proteins;Proto-Oncogene Proteins c-akt;Public Health;Pulmonary Inflammation;Recombinants;Research;Research Personnel;response;Role;Sampling;Scientist;self assembly;Serine;Signal Pathway;Signal Transduction;skills;smoothened signaling pathway;Students;Surface;synergism;tenure track;TLR4 gene;Training;Transcription Coactivator;Treatment Efficacy;United States;Up-Regulation;wound healing;Writing

PROJECT_TITLE: Targeting PI3K/BRD4 and Hedgehog Pathway in Alcohol Associated Liver Disease

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: TALLAHASSEE

ORG_DEPT: CHEMISTRY

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative Protein tyrosine sulfation plays important roles in, e.g., protein-protein interactions, inflammation, and viral infections. Due to the extreme lability of this posttranslational modification (PTM), global liquid chromatography/mass spectrometry analysis has not been feasible to date; however we discovered a novel workflow that partially enables such measurements. Here, we propose new strategies to further enhance detection and allow site determination of this widespread PTM in cells and tissues.

PI_NAMEs: HAKANSSON, KRISTINA  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: absorption;Acidity;adduct;Alkanesulfonates;Amino Acids;animal tissue;Anions;Arginine;Basic Amino Acids;Cations;Cell Culture Techniques;Cell division;Cell Physiology;Cell surface;Cells;Charge;chemical property;Chlorates;Collaborations;Complication;Data;data acquisition;Data Analyses;Data Set;Databases;Detection;detection method;Development;Disease;Dissociation;Electron Transport;Electrons;Electrospray Ionization;Environment;Enzymes;Eukaryotic Cell;experimental study;extracellular;Free Radicals;functional group;Gases;glycosylation;Golgi Apparatus;GORASP2 gene;Health;Heparin;hepatoma cell;HIV;improved;Infection;Inflammation;inhibitor;instrument;interest;Interphase;ionization;Ions;knock-down;Knock-out;Laboratories;liquid chromatography mass spectrometry;Liver;Location;Lysine;Manuals;mass spectrometer;Mass Spectrum Analysis;Measurement;Measures;Membrane Proteins;Methods;Mitotic;Modality;multi-photon;Nature;Normal Cell;novel;novel strategies;Organelles;peptide hormone;Peptide Sequence Determination;Peptides;Performance;Phase;Phosphopeptides;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Play;Positioning Attribute;Post Translational Modification Analysis;Post-Translational Protein Processing;prevent;Process;protein protein interaction;Protein Region;Protein Secretion;protein-tyrosine sulfotransferase;Proteins;Rattus;receptor binding;Regulation;Reporting;Retina;Role;rottlerin;Site;Sulfate;sulfotransferase;sulfurtransferase;Suramin;tandem mass spectrometry;Techniques;Technology;Tissues;tool;Trifluoroethanol;Tyrosine;tyrosine O-sulfate;Validation;Vesicle;Viral;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Enabling Mass Spectrometry Analysis of the Sulfoproteome

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]