ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health

ORG_STATE: TX

PHR: Project Narrative The mission of the Institute for Integration of Medicine and Science is to improve human health and well-being and reduce disparities by developing and disseminating innovative, measurable, patient- and community- focused best practices of clincial and translational science. Working synergistically with our partners and collaborators, we will accomplish this by strategic resource deployment, focusing on prevalent challenges in our region, including: 1) the health needs of our underserved Hispanic and rural populations, 2) the special health issues facing military and veteran populations, 3) rate-limiting barriers to translational science progress, and 4) limitations in the translational science workforce required to fill in critical knowledge gaps and improve health in South-Central Texas and the US. Successful strategies for mitigating clinical translational roadblocks and resolving health disparities will be disseminated to our regional partners, as well as the National CTSA Consortium.

PI_NAMEs: CLARK, ROBERT A (contact);HARGREAVES, KENNETH M;POTTER, JENNIFER SHARPE;RAMIREZ, AMELIE G

PROGRAM_OFFICER_NAME: LEYVA, FRANCISCO

PROJECT_TERMS: Acceleration;Address;Area;Automation;care outcomes;Cities;Clinical effectiveness;clinical practice;Clinical Research;Clinical Sciences;clinical translation;Collaborations;Communities;Community Health Aides;COVID-19 pandemic;Creativeness;Data;data quality;demographics;Discipline;Disease;disparity reduction;Dissemination and Implementation;dissemination science;diversity and inclusion;Education and Outreach;Effectiveness;Elements;Emergency response;Emergency Situation;Evaluation;evidence base;Faculty;flexibility;Fostering;Funding;Future;Goals;Growth;Health;health disparity;health equity;Health Priorities;Health Sciences;Healthcare;Healthcare Systems;Hispanic;Hispanic Populations;Home;Human;Human Resources;implementation science;improved;Inequity;Informatics;Infrastructure;innovation;Institution;Intervention;Knowledge;Latino;Leadership;Learning;Measurable;Medicine;Methods;Mexico;Military Personnel;military veteran;Minority;Mission;novel;opioid epidemic;Outcome;outcome disparities;Patients;Personal Satisfaction;Population;population based;Process;process improvement;Program Development;programs;Public Health Informatics;rapid growth;Research;Research Infrastructure;Research Priority;resilience;Resources;response;rural counties;Rural Population;Science;Services;South Texas;success;synergism;Testing;Texas;Training;Training Support;Translating;translational barrier;Translational Research;Translations;Vision;Work;Workforce Development

PROJECT_TITLE: Institute for Integration of Medicine & Science: A Partnership to Improve Health


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Neurosciences;Sleep Research

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Familial Natural Short Sleep (FNSS) is a rare Mendelian form of sleep where affected individuals have a lifelong requirement for sleep that is significantly less than the average person. Identification of genes/mutations in these families will help us understand the biology and molecular basis of sleep. Ultimately, understanding of such biological pathways may lead to novel targets for developing better drugs to improve sleep quality and efficiency.

PI_NAMEs: PTACEK, LOUIS J. (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Acceleration;ADRB1 gene;Affect;Alleles;American;autosome;Biological;Biology;Brain;Candidate Disease Gene;Cessation of life;Chronic;circadian;clinical database;Code;Collection;Databases;Detection;DNA Databases;DNA Library;Drosophila genus;Electroencephalography;Epidemiology;exome;exome sequencing;Family;Family member;Genes;Genetic;Genome;genome sequencing;Grant;GRM1 gene;Health;Homeostasis;Hour;Human;Human Biology;human subject;Immunity;Impairment;improvement on sleep;In Vitro;in vivo;Individual;Induced Mutation;interest;Introns;Investments;Maintenance;Massive Parallel Sequencing;Metabolism;Minority;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;novel;Nucleic Acid Regulatory Sequences;Open Reading Frames;Pathway interactions;Patient Self-Report;Persons;Pharmaceutical Preparations;Phenotype;Physicians;Population;proband;Proteins;psychosocial;Regulation;Reporting;Resources;Rest;Risk;Role;Sampling;Sleep;sleep behavior;Sleep Deprivation;Sleep Disorders;sleep pattern;sleep quality;sleep quantity;sleep regulation;Stream;Surveys;Technology;Temperature;trait;Translating;United States National Institutes of Health;Variant;Well in self;whole genome;Work

PROJECT_TITLE: Probing genetics and biology of human sleep homeostasis

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Mental Health;Neurosciences;Pediatric

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE In the last decade, connectivity and functional genomics studies have revealed spatiotemporal neural connectome changes and molecular changes, respectively. We propose to systematically analyze and integrate these two data modalities in the developing postnatal human brain to gain hitherto unattainable insights into human brain development and neuropsychiatric disease.

PI_NAMEs: HUANG, HAO  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: Adolescence;Adult;Age;Anatomy;Area;Atlases;autism spectrum disorder;Axon;Brain;Brain region;Candidate Disease Gene;cell type;Cells;Cerebral cortex;Childhood;Cognition;Communities;Complement;computerized tools;connectome;connectome data;Data;data harmonization;data integration;data modalities;Data Set;Dedications;Development;Diffusion Magnetic Resonance Imaging;early childhood;frontier;functional genomics;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic Transcription;genomic data;Genotype;Human;Human Development;Individual;infancy;innovation;insight;life span;Magnetic Resonance Imaging;Maps;Mediating;millimeter;Molecular;Mus;Neocortex;neocortical;neural;neural patterning;Neurons;neuropsychiatric disorder;next generation;novel;Pattern;postnatal;postnatal development;postnatal human;postnatal period;Prefrontal Cortex;prenatal;Process;Research;Resolution;Resources;Schizophrenia;Science;segregation;single nucleus RNA-sequencing;Source;spatiotemporal;Specimen;Techniques;Third Pregnancy Trimester;Time;Tissues;tool;transcriptome;transcriptome sequencing;transcriptomics;Translating;web portal

PROJECT_TITLE: Association of gene expression and brain connectivity in human cerebral cortex development and adulthood

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Neurosciences;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Circulating extracellular vesicles (EVs) are a rich source of genetic information and can provide a “window” into the genetic status of the releasing parental cells. In this proposal we will use rigorous methods and procedures to optimize kits and technologies to purify and characterize tumor specific EVs which will result in clinical utility for diagnosis, profiling and treatment monitoring of glioma patients.

PI_NAMEs: CARTER, BOB S (contact);LEE, HAKHO

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Acceleration;Address;Adoption;Age;assay development;Biological Assay;Biological Markers;Biopsy;Blood;Blood specimen;Blood Tests;brain tissue;cancer biomarkers;cancer cell;Cancer Detection;Cancer Diagnostics;candidate marker;candidate validation;Cells;cellular engineering;Circulation;CLIA certified;Clinical;clinical care;clinical translation;cohort;Collaborations;Collection;Coupled;Data;data mining;design;Detection;Development;Device Designs;Diagnosis;Diagnostic;Diagnostic tests;digital;Disease;Disease Marker;effective therapy;Elements;Ensure;Epidermal Growth Factor Receptor;Event;exosome;extracellular;extracellular vesicles;follow-up;General Hospitals;Genes;genetic information;genetic signature;Genetic Status;Glioma;Goals;Heterogeneity;high risk;high throughput screening;Histologic;improved;Industry;innovative technologies;Knowledge;Laboratories;liquid biopsy;Literature;Malignant Glioma;Malignant Neoplasms;Massachusetts;Messenger RNA;Methods;Modeling;Molecular;Molecular Analysis;molecular phenotype;Monitor;multidisciplinary;nanoengineering;Neurosphere;neurosurgery;Operative Surgical Procedures;Outcome;Outcome Measure;Outcomes Research;Parents;Patient-Focused Outcomes;Patients;Performance;Plasma;plasmonics;Population;preclinical study;Procedures;Proteins;Protocols documentation;Quality Control;rare variant;Recurrence;Recurrent disease;Recurrent tumor;Reference Standards;Reproducibility;Research;Research Design;Resources;Risk;RNA;Sampling;Sensitivity and Specificity;Series;Serum;Site;Source;Specificity;Standardization;Statistical Data Interpretation;success;Surface Antigens;Systems Biology;Technology;Testing;Time;Tissues;translational impact;Translations;tumor;tumor diagnosis;Variant;Vesicle;Work

PROJECT_TITLE: Standardized Molecular Analyses of Glioma EVs

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LAWRENCE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE – OVERALL Enabling technologies are critical for the understanding of the biochemical and physical basis of disease as well as its diagnosis. The COBRE Center for Molecular Analysis of Disease Pathways pursues health-related research that is focused on the development and application of these technologies to understanding disease processes. Two of the Center’s major missions are to recruit, support and mentor outstanding junior faculty investigators, and to establish, operate, and grow successful Core Labs that provide state-of-the-art capabilities and services to investigators.

PI_NAMEs: LUNTE, SUSAN M (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: base;Basic Science;Biochemical;Biological;Biology;Biomedical Engineering;Biomedical Research;biomedical resource;career;Centers of Research Excellence;Chemicals;Chemistry;Client;Development;Diagnosis;Disease;Disease Pathway;DNA Sequencing Facility;Environment;Faculty;Fees;Funding;genome sequencing;Genomics;Goals;Grant;Health;Human;Infrastructure;Institution;Kansas;Laboratories;member;Mentors;Microfabrication;Microfluidics;Mission;Molecular Analysis;Molecular Biology;nanofabrication;outreach;Pathway interactions;Phase;Pilot Projects;Positioning Attribute;Process;programs;recruit;Request for Applications;Research;research faculty;Research Personnel;Research Support;Science;Scientist;senior faculty;Services;success;Synthesis Chemistry;Technology;Universities;voucher

PROJECT_TITLE: Molecular Analysis of Disease Pathways


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PHR: The Nutrition Obesity Center at Harvard (NORC-H) includes a rich network of collaborating scientists performing translational studies in metabolism, utilizing advanced imaging, ‘omics, and metabolic phenotyping techniques. The Center’s thematic focus is on the translational mechanisms and consequences of nutritional and weight-related metabolic diseases across the lifespan, facilitated by three strong cores. The success of the Center is evidenced by strong success in securing nutrition and obesity related grants, publishing papers, and expanding cores.

PI_NAMEs: GRINSPOON, STEVEN K. (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Accounting;Achievement;Address;Adipose tissue;Appetite Regulation;Applications Grants;Area;base;burden of illness;career;career development;Caring;Cellular biology;Clinical;Collaborations;Communities;community engagement;Complex;Dedications;Desire for food;Development;Direct Costs;disability-adjusted life years;Disease;Doctor of Philosophy;Education and Outreach;Elements;Endowment;Ensure;Environment;Excision;Faculty;fasting glucose;Fostering;Funding;Genetic;Genomics;Goals;Grant;Hospitals;Human;Image;Immunologics;Individual;instructor;interest;Knowledge;Leadership;life span;Lipids;Malnutrition;medical schools;Medicine;member;men;Mentors;Mentorship;Metabolic Diseases;metabolic imaging;metabolic phenotype;Metabolism;model development;modifiable risk;National Institute of Diabetes and Digestive and Kidney Diseases;Neuroendocrinology;novel;nutrient absorption;nutrition;Nutrition Disorders;Nutritional;Obesity;Organ;Outcome;outreach;outreach program;Paper;Phenotype;Physicians;Physiology;Postdoctoral Fellow;Prevalence;Productivity;professor;programs;Public Health;Public Health Schools;Publications;Publishing;Regulation;Research;Research Personnel;Risk Factors;Scientist;Secure;Services;social;social determinants;Source;success;symposium;Talents;Teacher Professional Development;Techniques;Translating;Translational Research;translational scientist;translational study;Unhealthy Diet;United States;United States National Institutes of Health;web site;Weight;Woman;Work

PROJECT_TITLE: Nutrition Obesity Research Center at Harvard


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Advisory Committees;Award;base;Biomedical Research;Budgets;Caliber;career;Centers of Research Excellence;Client;Communication;Core Facility;Coupled;Disease Pathway;Educational workshop;Environment;Faculty;Funding;Goals;Institution;International;Kansas;Laboratories;Leadership;meetings;Mentors;Molecular Analysis;Monitor;Phase;Pilot Projects;Positioning Attribute;programs;Research;Research Personnel;Research Support;Resources;spelling;symposium;Universities;University adminstration;Vocational Guidance

PROJECT_TITLE: Administrative Core


PROJECT_TERMS: adipocyte biology;adipose imaging;Advisory Committees;Animal Model;Appetite Regulation;Area;Attention;Award;base;Bioinformatics;Biological Assay;career;Caring;Cell Culture Techniques;Cells;Cellular biology;Clinical;Clinical Research;Collaborations;Communities;COVID-19;Dedications;Desire for food;Disease;diversity and equity;Education;Elements;Ensure;Event;experience;Faculty;Food;Fostering;Functional Imaging;Funding;Genetic;Genomics;Goals;Grant;Hospitals;Human;Image;Imaging Techniques;Immunologics;Individual;Inflammation;innovation;Institution;interest;Investigation;life span;literacy;medical schools;Medicine;member;Mentors;Metabolic;Metabolic Diseases;metabolic imaging;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Methodology;Mission;Mitochondria;model development;neuroimaging;next generation;novel;nutrient absorption;nutrition;Nutritional Study;Obesity;Organ;organizational structure;Organoids;outreach;outreach program;Phenotype;Physiology;Positioning Attribute;Positron-Emission Tomography;Process;Productivity;programs;Public Health Schools;Publications;Publishing;Research;Research Personnel;Research Priority;Research Project Grants;Resources;Scholars Program;Scientific Advances and Accomplishments;Scientist;Services;single cell sequencing;social;success;symposium;System;Teaching Hospitals;Techniques;Tissues;Training;training opportunity;transcriptomics;Translating;translational pipeline;Translational Research;United States National Institutes of Health;virtual;Weight;Woman;Work;working group

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

PI_NAMEs: LUNDQUIST, ERIK A (contact)

PROJECT_TERMS: Affect;Area;base;Biological Sciences;Biology;Centers of Research Excellence;Chromatin;chromatin immunoprecipitation;Communication;cost;Custom;Data;Dedications;Development;Discipline;Disease;Disease Pathway;DNA Resequencing;DNA sequencing;DNA Sequencing Facility;Ecology;Engineering;experimental analysis;Experimental Designs;flexibility;Future;Genome;genome sequencing;Genomics;Genotype;Institution;instrument;instrumentation;interest;Kansas;Laboratory Research;Length;Libraries;Maps;Medical center;Methods;model organism;Molecular;Molecular Analysis;Museums;Mutation;Natural History;next generation sequencing;novel;outreach;Pharmacy facility;Phase;Pilot Projects;Positioning Attribute;Preparation;programs;Protocols documentation;Publishing;Research;Research Peer Review;Research Personnel;Research Project Grants;Running;Sequence Analysis;Services;Signal Pathway;Site;Small RNA;Techniques;Technology;tool;Training;transcription factor;transcriptome;transcriptome sequencing;Universities;Variant;whole genome;Wichita;Work

PROJECT_TITLE: Genome Sequencing Core


PI_NAMEs: TUNGE, JON A (contact)

PROJECT_TERMS: Address;Affinity;base;Benchmarking;Biological;biological systems;Biology;Biomedical Research;Biotin;Centers of Research Excellence;Chemicals;Chemistry;Client;Collection;Communicable Diseases;Communities;Core Facility;Custom;design;Development;Discipline;Disease Pathway;DNA Sequencing Facility;drug development;drug discovery;empowerment;Evaluation;fabrication;Faculty;Fluorescent Probes;fluorophore;Funding;Generations;Genes;genome sequencing;Goals;Imaging Device;In Vitro;in vitro Bioassay;in vivo;in vivo imaging;innovation;interest;Isotopes;Kansas;Lead;Mission;Molecular Analysis;Molecular Probes;nanofabrication;novel;Organic Chemistry;outreach;Pathology;Pathway interactions;Peptides;Pharmaceutical Chemistry;pharmacologic;Phase;Physiology;Pilot Projects;preclinical study;programs;Property;Proteins;Research;Research Infrastructure;Research Personnel;screening;Services;small molecule;success;Synthesis Chemistry;Techniques;Therapeutic;tool;Validation;Work

PROJECT_TITLE: Synthetic Chemical Biology Core


NIH_SPENDING_CATS: Biotechnology;Prevention

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: The proposed research is relevant to public health because the mechanisms identified will lead to the development of (bio)chemical strategies to manipulate Zn regulation in Gram-negative bacteria, which are related to many human pathogens. These strategies can be used to effect limitation of the essential micronutrient Zn, increase the toxicity of excess Zn, and thus restrict the growth of invading pathogens. Thus, the proposed research is relevant to the part of NIGMS's mission that pertains to laying the foundation for disease treatment and prevention.

PI_NAMEs: CHEN, PENG  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Abbreviations;antimicrobial;Bacteria;bacterial community;Bacterial Model;Behavior;Biochemical;Biological;Biological Models;Biophysics;Cell Communication;cell community;Cells;Cellular biology;cellular imaging;Chemicals;Collaborations;Communities;Complex;Cytosol;Development;Disease;disorder prevention;DNA;efflux pump;Engineering;Environment;Escherichia coli;Foundations;Genetic Engineering;Goals;Gram-Negative Bacteria;Green Fluorescent Proteins;Growth;Homeostasis;Human;human disease;human pathogen;imaging approach;imaging modality;Impairment;In Vitro;innovation;insight;International;Invaded;Knowledge;Left;Life;Location;Mechanics;Membrane;Metals;microbial community;Microfluidics;Micronutrients;Mission;model organism;Molecular Chaperones;National Institute of General Medical Sciences;novel;optogenetics;Outcome;pathogen;Pathway interactions;periplasm;Physiological;polydimethylsiloxane;Prevention;Preventive;Process;programs;Progress Reports;Proteins;Public Health;Reaction;Regulation;Repression;Research;Scheme;single molecule;single-molecule FRET;spatiotemporal;Structure;System;Therapeutic;Toxic effect;Transcriptional Regulation;Transition Elements;uptake;Zinc deficiency

PROJECT_TITLE: Unusual mechanisms of metal regulation in bacteria: from single molecules to single cells to cell communities

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


PI_NAMEs: FASANO, ALESSIO  (contact)

PROJECT_TERMS: Adipose tissue;animal model development;ATAC-seq;Bioinformatics;Biological Assay;Celiac Disease;Cell Separation;Cells;Cellular biology;Charge;ChIP-seq;Cleavage Under Targets and Release Using Nuclease;Collaborations;Complex;Computer Analysis;Computers and Advanced Instrumentation;Consultations;Core Facility;Data;design;Development;Educational workshop;Endothelium;epigenomic profiling;Equipment;Gene Expression Profiling;Genomics;Goals;Grant;gut microbiota;Hi-C;high throughput screening;Human Resources;Image;Immune;Immunologics;Immunology;instrument;interdisciplinary approach;Intestinal Mucosa;Liver;Medical Students;Metabolic;Metagenomics;microscopic imaging;Microscopy;Molecular Analysis;Molecular Biology;Morphology;Muscle;next generation sequencing;Nutrient;nutrition;Obesity;Pathway interactions;Phenotype;Philosophy;Proteomics;Research;Research Design;Research Personnel;Retirement;Role;screening;Services;single-cell RNA sequencing;summer internship;Supervision;Techniques;Technology;Training;undergraduate student

PROJECT_TITLE: Genomics and Cell Biology Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer

PROJECT_TERMS: Biological;Biological Process;Biology;Biomedical Research;Biophysics;Cancer Patient;Cell Communication;Cells;Centers of Research Excellence;Chemicals;Chemistry;Clinical;Clinical Chemistry;clinical diagnostics;Complex;Custom;design;Development;Devices;Disease Pathway;DNA Sequencing Facility;drug discovery;drug metabolism;Electronics;Engineering;Environment;Equipment;exosome;fabrication;genome sequencing;Goals;Growth;Hematopoietic Neoplasms;Human;Human Resources;Infrastructure;Institution;integrated circuit;interest;Investigation;Kansas;Lab On A Chip;Laboratories;laboratory development;manufacturing technology;Methods;Microfabrication;Microfluidic Microchips;Microfluidics;Molecular Analysis;nano;nanofabrication;nanofluidic;nanoscale;Neoplasm Circulating Cells;novel;Organ;organ on a chip;outreach;Phase;Physics;Physiological Processes;Privatization;Process;Production;Research;Research Infrastructure;Research Personnel;Resources;Techniques;Technology;Training;Universities

PROJECT_TITLE: KU Nanofabrication Facility


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Climate-Related Exposures and Conditions;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative These studies test the potential contribution of nanoparticle air pollution (AP) exposures, and of specific AP contaminants to neurodevelopmental disorders. It will also extend current studies to determine the relevance of the mouse model, the basis of sex differences in such effects, and how nanoparticles reach and are processed in brain. It will then extend studies to post-mortem brain tissue from individuals diagnosed with neurodevelopmental disorders to assess potential vulnerability of developing brain to AP.

PI_NAMEs: CORY-SLECHTA, DEBORAH A (contact)

PROGRAM_OFFICER_NAME: LAWLER, CINDY P

PROJECT_TERMS: Acceleration;African;Air;Air Pollution;Attention Deficit Disorder;autism spectrum disorder;Autopsy;Behavioral;Biological;Brain;brain iron;brain tissue;Corpus Callosum;design;Diagnosis;epidemiology study;Exposure to;Ferritin;Health protection;Human;human model;human tissue;Individual;Inhalation;Inhalation Exposure;Life;male;Metals;Microglia;mouse model;Mus;Myelin;nanoparticle;Neurodevelopmental Disorder;neuroinflammation;neuropathology;neurotoxicity;Neurotoxins;Nose;novel;Oxidation-Reduction;Oxidative Stress;particle;particle exposure;Phenotype;postnatal;Pregnancy;Process;Production;Public Health;Reporting;Risk Factors;Schizophrenia;Series;Sex Differences;Source;Stress Tests;Testing;Third Pregnancy Trimester;Toxic effect;Trace Elements;Ultrafine;ultrafine particle;uptake

PROJECT_TITLE: Early Life Air Pollution Exposures as a Risk Factor for Neurodevelopmental Disorders


PI_NAMEs: TORRIANI, MARTIN  (contact)

PROJECT_TERMS: Acceleration;Achievement;Address;Area;base;Body Composition;Boston;Brain;Brain imaging;brain morphology;Charge;Clinical;Clinical Research;Communities;Consultations;cost;cost effective;Data;deep learning algorithm;Development;Environment;Faculty;Functional Magnetic Resonance Imaging;Funding;Head;Human;Image;Image Analysis;imaging facilities;imaging modality;imaging study;Imaging Techniques;Imaging technology;in vivo;innovation;Institution;interest;large datasets;Liver;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measurement;Measures;Medical Imaging;medical schools;member;metabolic imaging;Metabolism;Mission;Muscle;neural circuit;neuroimaging;non-invasive imaging;novel;nutrition;Obesity;Organ;Physiological;Physiology;Positron-Emission Tomography;Productivity;professor;Protocols documentation;Quality Control;Radiology Specialty;radiotracer;Research;Research Design;Research Personnel;research study;Resources;service member;Services;Specialist;Structure;technological innovation;Technology;Tissues;Tracer;Translational Research;ultrasound;Visceral fat;X-Ray Computed Tomography

PROJECT_TITLE: Metabolic Imaging Core


PROJECT_TERMS: Advertising;Advisory Committees;Applications Grants;career;career development;Centers of Research Excellence;Collaborations;Disease Pathway;Educational workshop;Evaluation;Faculty;faculty mentor;Funding;Goals;Grant;Group Meetings;Individual;Mentors;Molecular Analysis;Monitor;novel;Phase;Pilot Projects;programs;Publications;Research;research and development;Research Personnel;Research Project Grants;Research Support;Secure;senior faculty;skills;Testing;United States National Institutes of Health;Writing

PROJECT_TITLE: Pilot Projects Program


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative While genetic profiling studies have proposed that a step-wise acquisition of mutations drives acute myeloid leukemia (AML) development, the impact of this mutation order on leukemogenesis has not been fully delineated. The proposal described herein aims to interrogate the clonal architecture of AML, particularly NPM1-mutant AML, at the single cell level to identify precise mutation order and common co-occurring mutational patterns which lead to clonal dominance for the development of novel sequential mutagenesis models of AML. These studies will generate accurate models of leukemogenesis to uncover molecular dependencies as clinically tractable targets of NPM1-mutant AML.

PI_NAMEs: MILES, LINDE A (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;adult leukemia;Alleles;Architecture;Biology;cancer cell;career;career development;Cell Surface Proteins;Cells;chemotherapy;Clinical;Clinical Data;Clonal Evolution;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Communication;Credentialing;Cytotoxic Chemotherapy;Data;Dependence;Development;Disease;disease model;DNA Integration;DNA Sequence Alteration;DNA sequencing;DNMT3a;Doctor of Philosophy;Environment;Epigenetic Process;Event;Evolution;FLT3 gene;Focus Groups;Fostering;Gene Expression;Gene Frequency;Generations;Genes;Genetic;Genetic Fingerprintings;genetic profiling;Genetic Transcription;genetic variant;Genomics;Goals;Grant;Hematologic Neoplasms;Hematopoietic;Hematopoietic stem cells;Human;Impairment;improved;in vivo Model;insight;Institution;Lead;Leadership;leukemia;leukemia treatment;Leukemic Cell;leukemic transformation;leukemogenesis;Malignant - descriptor;Malignant Neoplasms;Medicine;member;Memorial Sloan-Kettering Cancer Center;Menin;Modeling;Molecular;Molecular Profiling;mouse model;Mutagenesis;mutant;Mutate;Mutation;Myelogenous;new therapeutic target;novel;novel therapeutic intervention;NPM1 gene;Oncogenic;Oncology;Output;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pattern;Penetrance;Phase;Phenotype;Postdoctoral Fellow;Pre-Clinical Model;Preleukemia;programs;Proliferating;Protein Analysis;protein expression;Proteins;recombinase;Research;research and development;Resolution;Resources;response;RNA;Role;Sampling;Services;Signal Transduction;single cell sequencing;skills;Structure;Study models;Technical Expertise;Techniques;Therapeutic;Therapeutic Intervention;therapeutic target;tool;treatment response

PROJECT_TITLE: Dissecting the role of clonal evolution in NPM1-mutant AML

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


PI_NAMEs: SOUKAS, ALEXANDER A (contact)

PROJECT_TERMS: Address;Adipocytes;Animals;Applications Grants;base;Biochemical;Bioinformatics;Biological Assay;Biology;Blood specimen;Body Composition;cell immortalization;Cell Respiration;cell type;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;Complex;Complex Analysis;Computer Analysis;Consult;Custom;Data;Data Set;Diet;Disease;disease model;Education;Energy Metabolism;experience;Faculty;Funding;Gene Expression;Gene Targeting;Generations;Genetic Engineering;genome editing;genomic data;Genomics;glucose output;Goals;Grant;Hand;Health;Hepatocyte;Human;human disease;Human Genetics;human model;human tissue;in silico;in vivo;Individual;induced pluripotent stem cell;Infrastructure;innovation;insight;insulin signaling;knock-down;Knock-out;Laboratories;large datasets;lipidomics;Lipolysis;Mass Spectrum Analysis;Measures;member;Metabolic;metabolic abnormality assessment;metabolic phenotype;Metabolism;metabolomics;Methodology;Mitochondria;model development;Modeling;Modernization;mouse model;Mus;next generation;nutrition;Obesity;overexpression;Pathway interactions;Patients;Phenotype;Physiological;Physiology;Pluripotent Stem Cells;Process;Production;Productivity;Proteomics;Publications;Reproducibility;Research;Research Personnel;research study;Resources;respiratory;Sampling;satisfaction;Science;Services;success;Techniques;Technology;Testing;Tissue Sample

PROJECT_TITLE: Metabolic Phenotyping Core


NIH_SPENDING_CATS: Clinical Research;Nutrition;Obesity

PI_NAMEs: STANLEY, TAKARA LEAH (contact)

PROJECT_TITLE: Pilot and Feasibility Core


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: CHAMPAIGN

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE The proposed training program will establish a nurturing, rigorous doctoral bridge program for transitioning Master’s students at Fisk University to Ph.D. programs at University of Illinois, Urbana-Champaign, specifically in the areas of biomedical data science, computational biology and biophysics. Students will receive interdisciplinary training encompassing technical, operational and professional skills acquisitions through rigorous course work, multi-layered mentoring, support, and inclusive activities that promote improved self- confidence, science identity, and competency. The results of this program will significantly increase the number of successful under-represented doctorate researchers in the workforce of data science and quantitative biology that currently have the most pronounced disparity within the biomedical sciences.

PI_NAMEs: BOPPART, STEPHEN A;LIMBIRD, LEE E;SONG, JUN S (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: bridge to the doctorate;Illinois;Universities

PROJECT_TITLE: Bridge to the Doctorate at University of Illinois at Urbana-Champaign

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: Chicago

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Malaria is caused by parasites of the genus Plasmodium and over one billion people are at risk of infection every year. Unfortunately, the rapid development of resistance to all current antimalarials highlights the urgent need to develop new drugs with different mode of actions to overcome this pressing problem. This work aims to optimize two novel, inexpensive and effective classes of antimalarials that target multiple life stages of the parasite. In addition, the proposed studies to uncover how these antimalarials work will reveal valuable information to define unknown cellular (on and off) targets in malaria parasite that in turn will aid the development of safer treatments to circumvent drug resistant malaria in the campaign for disease eradication.

PI_NAMEs: CARLIER, PAUL R (contact);CASSERA, MARIA BELEN

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Address;Adsorption;Affect;analog;Anti-malarials;Applications Grants;Artemisinins;asexual;Azides;Benzofurans;Biological Assay;Biological Availability;Blood;Cessation of life;Chemicals;Chemistry;chemoproteomics;chemotherapeutic agent;Chloroquine;Clinical;Complement;Consensus;Contracts;Copper;Development;Diazomethane;Disease;Dose;drug candidate;Drug Kinetics;Drug resistance;Escherichia coli;Evolution;Excretory function;experimental study;Funding;genome sequencing;Goals;Growth;Human;improved;In Vitro;in vivo;Infection;infection risk;Lead;lead optimization;Libraries;Life;Ligands;Liver;Malaria;malaria infection;Mammalian Cell;Medical;Metabolism;meter;Modification;Molecular Target;mouse model;Mus;novel;novel therapeutics;Oral;Oral Administration;Parasite resistance;Parasites;pathogen;Pharmaceutical Preparations;pharmacophore;Phenotype;photolysis;Plasma;Plasmodium;Plasmodium berghei;Plasmodium falciparum;Population;Populations at Risk;Positioning Attribute;pre-clinical;preclinical development;prevent;Probability;Property;Proteins;Proteomics;Rattus;Recrudescences;Resistance;Resistance development;resistance mechanism;Risk;scaffold;screening;Series;Solubility;Structure;Structure-Activity Relationship;Synthesis Chemistry;timeline;Toxic effect;Triage;United States National Institutes of Health;virtual;whole genome;Work

PROJECT_TITLE: Optimization of antimalarials targeting multiple life stages of the parasite

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Nutrition;Obesity

PI_NAMEs: DUGGAN, CHRISTOPHER P (contact)

PROJECT_TERMS: Advocacy;Advocate;Allied Health Sciences;Area;Award;base;Biomedical Research;Boston;career;case-based;Clinical;Collaborations;Communication;Communities;Consultations;Data;Dedications;Development;Discipline;doctoral student;early-career faculty;Education;Educational Curriculum;elderly nutrition;Event;Faculty;Fostering;Funding;Generations;Goals;graduate student;Grant;Hour;Individual;interdisciplinary collaboration;Knowledge;Leadership;Learning;lectures;Link;medical schools;Medical Students;Medicine;member;Mentors;Mentorship;Metabolism;Methodology;Newsletter;next generation;novel;nutrition;Nutritional Study;Obesity;peer;Postdoctoral Fellow;programs;Provider;Publications;Research;Research Design;Research Personnel;Resources;Scholars Program;Schools;Scientific Advances and Accomplishments;Source;statistical service;statistics;Students;symposium;System;Training;undergraduate student;United States National Institutes of Health;virtual platform;Voice;web site

PROJECT_TITLE: Enrichment Program


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: HEIDELBERG

ORG_COUNTRY: GERMANY

ORG_FIPS: GM

ORG_NAME: EUROPEAN MOLECULAR BIOLOGY LABORATORY

PHR: PROJECT NARRATIVE Understanding human health and disease requires a deep understanding of gene function for all human genes. The lab mouse is genetically very similar to humans and is used to study the causes of common and rare human diseases. We provide access to millions of data points about mice that have had a gene removed, the data analysis discovers new gene functions and improves our understanding of normal and disease processes with the prospect of improving diagnoses for rare genetic disease and illuminating the causes of common diseases such as heart disease.

PI_NAMEs: CACHEIRO MARTINEZ, PILAR ;PARKINSON, HELEN ELIZABETH (contact);SMEDLEY, DAMIAN ;WELLS, SARA

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Address;Advanced Development;Algorithms;analysis pipeline;Automation;Biomedical Research;biomedical resource;Brain;candidate identification;Catalogs;Clinical;Collaborations;Communication;Communities;Complex;Computer software;Data;data access;data acquisition;Data Analyses;data archive;Data Coordinating Center;data integration;data quality;Data Set;data standards;Detection;Development;Diagnosis;Diagnostic;Disease;disease model;dissemination strategy;Ensure;experience;gene discovery;gene function;Generations;Genes;Genetic;Genetic Diseases;Genome;genome browser;Genome Components;genome wide association study;Genomics;Goals;Health;Heart Diseases;Human;human disease;Human Genetics;Image;Image Analysis;improved;informatics infrastructure;interest;International;Intuition;Investigation;Knowledge;Learning;Link;Lung;Machine Learning;Manuals;Maps;Marketing;MeSH Thesaurus;Methods;mouse genome;Mus;novel;Ontology;outreach;Pathway interactions;Phase;phenomics;Phenotype;phenotypic data;Population;Process;Production;Protocols documentation;Publications;Quality Control;Rare Diseases;rare genetic disorder;Reporting;Reproducibility;Research;Research Personnel;Resources;Role;Semantics;Standardization;Statistical Data Interpretation;Statistical Methods;Structure;symposium;Techniques;Testing;therapeutic target;tool;Training;Translations;Update;Validation;Visualization;Visualization software;web portal;working group

PROJECT_TITLE: Mouse Phenotyping Informatics Infrastructure - Data acquisition, integration, analysis and translation of high throughput mammalian phenotyping data.


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Mammalian cells are constantly exposed to multiple, simultaneous signaling cues, each activating distinct transcriptional programs. Signal stimulation leads to the assembly of megadalton-sized enhancer complexes as membraneless structures called condensates. Our research program will examine the role of nuclear bodies and enhancer-bound condensates in coordinating genome-wide transcriptional programs and how this mechanism opens up novel regulatory paradigms in spatial gene control.

PI_NAMEs: NAIR, SREEJITH JANARDHANAN (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: 3-Dimensional;Acute;Address;Architecture;Binding;Biological;Biological Assay;Biophysics;Cells;Chromatin;Chromatin Structure;Communication;Complex;CRISPR screen;Cues;Data;Disease;Enhancers;Enzymes;Event;Exposure to;Gene Expression;Gene Expression Regulation;Genes;genetic approach;Genetic Transcription;Genome;genome-wide;genomic tools;Genomics;Homeostasis;Imaging Device;innovation;insight;Knowledge;Ligands;Link;Mammalian Cell;Membrane;Mentors;Molecular;multidisciplinary;mutation screening;next generation;next generation sequencing;novel;Nuclear;Nuclear Hormone Receptors;Organelles;Pathway interactions;Physical condensation;Prevalence;programs;Property;Proteins;Proteome;prototype;Regulation;Regulatory Element;Reporting;Repression;Research;Research Personnel;RNA;Role;Science;Shapes;Signal Induction;Signal Transduction;solid state;spatiotemporal;Structure;superresolution imaging;Technology;tool;Training;transcription factor;Untranslated RNA;Work

PROJECT_TITLE: Regulatory Mechanisms Linking Spatial Gene Control and Genome Organization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: NEW YORK

ORG_NAME: HERBERT H. LEHMAN COLLEGE

PHR: NARRATIVE The successful cryopreservation of proteins requires the use of cryoprotectant molecules as co- solvents to prevent the formation of crystalline water, which can led to protein denaturation. This SC3 grant is centered around developing novel methods for the cryopreservation of biomolecules by exploiting the glass polymorphism in water, i.e., the existence two amorphous phases with different properties. Because our studies are based on non-equilibrium Molecular Dynamics simulations, these results will provide a fundamental understanding of the atomistic mechanism of protein preservation in glassy water without the use of co-solvents.

PI_NAMEs: LOPEZ-QUINONES, GUSTAVO E (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TITLE: Novel Methodologies for the Preservation (and Recovery) of Proteins at Low Temperature


ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Todd Brown, MD, PhD is an endocrinologist and epidemiologist at Johns Hopkins University whose primary research and clinical interest over the last 20 years has focused on the causes and consequences of endocrine and metabolic dysfunction in persons living with HIV. This career development award renewal will provide additional training and continue to provide protected time for him to mentor trainees interested in patient-oriented research in the HIV Comorbidity field.

PI_NAMEs: BROWN, TODD T (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Aging;aging related;aging related disease;AIDS clinical trial group;Area;Award;Benefits and Risks;Bone Density;Cardiac;Cardiology;Cardiovascular Diseases;career development;Clinical;Clinical Management;Clinical Research;cohort;Cohort Studies;Communicable Diseases;comorbidity;Consequences of HIV;Coronary Arteriosclerosis;Country;Data;Diabetes Mellitus;Discipline;Disease;Doctor of Philosophy;Endocrine;Endocrine System Diseases;Endocrinologist;Endocrinology;Environment;Epidemiologist;Epidemiology;experience;Faculty;Fracture;fracture risk;fragility fracture;Functional disorder;Funding;General Population;Geriatrics;glycosylation;Goals;Grant;Hand Strength;Health;health related quality of life;Hepatitis C;High Prevalence;high risk;HIV;HIV/HCV;Hypogonadism;Immunoglobulin G;Individual;Inflammation;Inflammatory;Infrastructure;Institution;Insulin Resistance;interest;Internal Medicine;International;Intravenous;Investigation;K-Series Research Career Programs;Link;medical specialties;Medicine;member;men;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Mid-Career Clinical Scientist Award (K24);Morphology;multidisciplinary;next generation;novel;older men;Organ;Osteoporosis;Outcome;Pathogenesis;patient oriented research;Pattern;Peer Review;Persons;Physical Function;Plasma Proteins;Play;Polysaccharides;Population;Prevention strategy;Productivity;professor;programs;Publications;Quality of life;Research;Research Personnel;Research Support;Resources;Risk;Risk Factors;Role;Science;Secondary Prevention;Series;skills;systemic inflammatory response;Testing;Testosterone;testosterone replacement therapy;The Multicenter AIDS Cohort Study;Time;Training;translational pipeline;Translational Research;United States National Institutes of Health;Universities;walking speed;Woman;Women's Interagency HIV Study;Work

PROJECT_TITLE: Mentoring in Endocrine and Metabolic Abnormalities in HIV and Aging

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Children aged 6 and 11 were resuscitated from cardiac arrest and found by our medical centers to have life- threatening heart rhythm abnormalities, and genetic testing found DNA variants altering a calcium-sensing protein called calmodulin (a known possible cause of these abnormalities); however, these variants were of uncertain significance. Because we had previously generated a ‘variant effect map’ of calmodulin by testing nearly all possible amino-acid-changing variants, functional evidence was immediately available to provide certainty to these patients’ diagnosis and enable genetic testing of calmodulin for other family members. Our CardioVar team proposes to generate variant effect maps for more than 25 key cardiovascular disease genes, providing systematic evidence of variant function to assist real-time clinical diagnosis and illuminate molecular mechanisms of cardiovascular disease.

PI_NAMEs: ASHLEY, EUAN A;RODEN, DAN M (contact);ROTH, FREDERICK P

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: aged;Amino Acids;Arrhythmia;Atherosclerosis;Atlases;Automobile Driving;Bar Codes;Benign;Biological;Biological Assay;Biology;Calcium;Calmodulin;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;cardiovascular effects;Cardiovascular system;Cause of Death;cell growth;Cell Size;Cells;Cellular Assay;Child;Clinical;clinical care;clinical diagnosis;Clinical Management;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Communities;Data;Decision Support Systems;Development;Diagnosis;disability;Disease;DNA;drug development;Dyslipidemias;Electrocardiogram;Electrophysiology (science);Environmental Risk Factor;experience;Family;Family member;Functional disorder;Gene Frequency;Genes;Genetic;genetic testing;genetic variant;genome sequencing;genome wide association study;Genomic medicine;Genomic Segment;Heart Arrest;Heart Diseases;Heart failure;heart rhythm;high throughput screening;Human;Immunofluorescence Immunologic;improved;In Situ;in vitro Assay;Individual;induced pluripotent stem cell;insight;Institution;Ion Channel;Letters;Life;lipid disorder;Lipoproteins;Low-Density Lipoproteins;machine learning model;Maps;Measures;Medical center;Medicine;Membrane Proteins;Minor;Molecular;Mutagenesis;novel;Nucleotides;patch clamp;Pathogenesis;Pathogenicity;Patients;Performance;Phenotype;protein function;protein structure;Proteins;public database;Publications;rare variant;Reagent;Research Personnel;Resources;response;Scientist;Secondary Protein Structure;Site;Standardization;Surface;System;Tertiary Protein Structure;Testing;Time;Toxin;trait;Uncertainty;Update;uptake;Variant;Vascular Diseases;Vision;Zebrafish

PROJECT_TITLE: Systematically mapping variant effects for cardiovascular genes

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Precision Medicine;Primary Health Care;Social Determinants of Health

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE Chronic kidney disease (CKD) affects 37 million Americans, costs tens of billions of dollars annually, and can lead to progressive kidney failure, cardiovascular disease (CVD), and early mortality. In this proposal we seek to continue to serve as a CKD recruitment site to obtain, in a safe and ethical manner, kidney tissue from individuals with hypertension or diabetes to advance our understanding of CKD and develop new treatments. The kidney tissue samples will be used to create a kidney tissue atlas that includes information on the proteome, metabolome, and transcriptome of individual kidney cells, their spatial distribution, the inter-cellular pathology of CKD, and importantly how these factors vary in different stages and types of CKD.

PI_NAMEs: ROSAS, SYLVIA E;WAIKAR, SUSHRUT S. (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: Academic Medical Centers;adjudication;Adult;Affect;Agreement;Amendment;American;Animal Model;Awareness;Biopsy;Biopsy Specimen;Boston;Budgets;Cardiovascular Diseases;Chronic Kidney Failure;Clinic;Clinical;clinical research site;Collection;Communities;community advisory board;Consent Forms;cost;Development;Diabetes Mellitus;Diabetic Nephropathy;Disparity population;Education;eligible participant;Employment;End stage renal failure;Endocrinologist;Endocrinology;Enrollment;Ensure;Ethics;ethnic minority;Exclusion Criteria;experience;follow-up;Functional disorder;Geography;Glomerular Filtration Rate;high risk;Hospitals;Human;Hypertension;improved;inclusion criteria;Individual;Infrastructure;insight;Insulin-Dependent Diabetes Mellitus;Interdisciplinary Study;Investigation;Israel;Kidney;kidney biopsy;kidney cell;Kidney Diseases;Kidney Failure;Knowledge;Laboratories;Leadership;literacy;Literature;Longitudinal cohort study;Medical center;member;metabolome;Molecular;molecular pathology;mortality;Nephrology;novel;novel strategies;Participant;participant enrollment;Pathologic;Pathology;patient engagement;patient population;Patients;Phase;PhenX Toolkit;Population;Population Heterogeneity;precision medicine;primary care clinic;Primary Care Physician;Proteome;protocol development;Protocols documentation;Public Health;racial minority;Radial;recruit;Renal function;Research;Research Personnel;retention rate;Risk;Role;Safety;safety net;Science;Site;social health determinants;socioeconomic disadvantage;Spatial Distribution;Specialized Center;Techniques;tertiary care;Tissue atlas;Tissue Sample;Tissues;transcriptome;Vulnerable Populations;Woman

PROJECT_TITLE: Boston Chronic Kidney Disease Research Biopsy Center


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy;Kidney Disease;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE Immunotherapy has produced highly durable responses with minimal side effects in renal cell carcinoma, though only a subset of patients respond and there are no current ways to predict response. This proposal identifies a biomarker to fill this void, and seeks to fundamentally understand how this biomarker predicts response. This knowledge will then be implemented to expand the patients who may benefit from immunotherapy, improving patient outcomes and quality of life.

PI_NAMEs: MCGRAIL, DANIEL JAMES (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Advisory Committees;Area;biological adaptation to stress;Biological Markers;Candidate Disease Gene;candidate selection;career;Cells;Classification;Clear cell renal cell carcinoma;Clinical;clinical biomarkers;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Combined Modality Therapy;computational pipelines;CRISPR screen;cytokine;Cytometry;Cytoplasm;Defect;DNA;DNA biosynthesis;DNA Damage;Early Diagnosis;Ensure;Environment;Etiology;Faculty;Gene Deletion;Gene Expression;Gene Expression Profile;Genes;Genetic Engineering;genetic signature;Genetically Engineered Mouse;Genotype;Goals;high throughput screening;Image;Immune;immune checkpoint blockade;Immune response;Immunobiology;Immunologics;Immunologist;Immunology;Immunooncology;Immunotherapy;improved;improved outcome;in vivo;insight;Knowledge;Lead;Link;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Medical Oncology;member;Mentors;Mentorship;Modality;Modeling;mouse model;multiplexed imaging;Mus;Mutation;Neoplasm Transplantation;neoplastic cell;novel therapeutics;Outcome;overexpression;patient stratification;patient subsets;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Population;predicting response;predictive marker;Production;programmed cell death ligand 1;Proteins;Quality of life;Recording of previous events;Renal Carcinoma;Renal Cell Carcinoma;replication stress;Research Personnel;Resistance;response;responsible research conduct;Role;Sampling;Screening Result;side effect;Signal Transduction;Single-Stranded DNA;skills;Stimulator of Interferon Genes;STING1 gene;success;System;targeted treatment;tenure track;Testing;tool;Training;transcriptome sequencing;transplant model;tumor;tumor-immune system interactions;Tumor-infiltrating immune cells;Validation

PROJECT_TITLE: Determining the Immunological Consequences of DNA Replication Stress Response Defects in Renal Cells Carcinoma to Improve Immunotherapy Outcomes


ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE Important fundamental preclinical, translational, and clinical questions exist in the allied fields of Anesthesia, Critical Care, and Pain Medicine. The goal of this application is to continue support for rigorous, well-mentored training of physician-scientists who will contribute to the public good by conducting key research and serving as academic leaders in the specialty of Anesthesiology.

PI_NAMEs: MINTZ, CYRUS DAVID (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Anesthesiology;Critical Care;Medicine;Postdoctoral Fellow;Research Training

PROJECT_TITLE: Postdoctoral Research Training in Anesthesiology and Critical Care Medicine


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurosciences;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases;West Nile Virus

ORG_CITY: CHAPEL HILL

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Powassan virus is a tick-borne flavivirus that is becoming more common in the United States and can cause neuroinvasive disease such as encephalitis, meningitis, or paralysis. However, disease severity varies dramatically among people and it is not well understood how host genetic differences contribute to the outcome of neuroinvasive flavivirus infection. We will use genetically diverse Collaborative Cross mice to understand how polymorphisms in host antiviral response genes influence the disease caused by Powassan virus and other neuroinvasive flaviviruses such as the mosquito-borne West Nile virus and Japanese encephalitis virus.

PI_NAMEs: LAZEAR, HELEN  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Alleles;Anti-viral Response;blood-brain barrier permeabilization;Brain;Candidate Disease Gene;Cells;Central Nervous System;Clinical;Culicidae;Disease;Disease Outbreaks;Disease Outcome;Encephalitis;Exhibits;Fever;Flavivirus;Flavivirus Infections;Foundations;Future;Genes;Genetic;Genetic Polymorphism;Genetic Variation;Human;Immune;Immunologic Factors;Immunologics;Inbred Mouse;Incidence;Infection;Inflammatory;Inflammatory Response;insight;Integration Host Factors;Interferons;Investigation;Ixodes;Japanese encephalitis virus;Leucocytic infiltrate;Lyme Disease;Maps;Measures;Mediating;Meningitis;mosquito-borne;Mus;Nervous System Disorder;Neurons;North America;novel;Outcome;Paralysed;Pathogenesis;Pathogenicity;Pathology;Persons;Phenotype;Population;Powassan virus;Predisposition;Quantitative Trait Loci;Recombinants;Reproducibility;Resistance;response;Serum;Severity of illness;Stimulus;Symptoms;System;tick transmission;Tick-Borne Diseases;tick-borne flavivirus;Ticks;Tissues;transmission process;United States;Viral;Viral Load result;Viral Pathogenesis;Viral Physiology;viral resistance;viral transmission;Viremia;Virus;Virus Diseases;Virus Replication;West Nile virus;Work

PROJECT_TITLE: Host Factors Controlling Neuroinvasive Flavivirus Pathogenesis

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: MADISON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative This project is relevant to public health because the outcomes will facilitate studies that are aimed at developing therapies that can attenuate or reverse the loss of skeletal muscle that occurs during a variety of conditions such as prolonged bed rest, cachexia, muscular dystrophies, myopathies, immobilization, and aging.

PI_NAMEs: HORNBERGER, TROY A (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Ablation;Aging;Attenuated;Bed rest;Cachexia;Chronic;Coin;Data;Dependence;Disease;disorder prevention;Electron Microscopy;Elements;Equilibrium;Event;Foundations;Future;gene therapy;Goals;Growth;Hypertrophy;Imaging Techniques;Immobilization;improved;Knockout Mice;Knowledge;Link;Location;Maintenance;mechanical drive;mechanical load;mechanical signal;mechanical stimulus;Mechanics;Mediating;Modeling;mouse model;Muscle;muscle form;Muscle function;Muscular Dystrophies;Myofibrils;Myopathy;Nature;Outcome;Physiological;Play;Process;Protein Biosynthesis;protein degradation;Public Health;Quality of life;Radial;Regulation;resistance exercise;Resolution;response;Role;Sarcomeres;Series;Signal Pathway;Signal Transduction;Site;Skeletal Muscle;skeletal muscle growth;skeletal muscle wasting;Stimulus;Techniques;Technology;Testing;therapy development;Visualization;Weight;Work

PROJECT_TITLE: Identifying the Structural Adaptations that Drive the Mechanically Induced Growth of Skeletal Muscle

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Orphan Drug;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Minimal residual disease (MRD) after upfront treatment of multiple myeloma (MM) is used to identify complete response patients at high risk for progression/relapse, however the standard-of-care for MRD assessment by bone marrow aspirates and imaging are not complete and prone to false-negatives. This work seeks to integrate serial epigenetic profiles in circulating cell-free DNA with imaging data to develop, validate, and clinically translate the composite model for MRD detection and tacking of MRD. Successful completion of this study will allow for timely implementation of additional therapeutic strategies and reduce morbidity and mortality among MM patients.

PI_NAMEs: CHIU, BRIAN C-H (contact);DERMAN, BENJAMIN ;ZHANG, WEI

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Address;Adult;Affect;Aftercare;Age;Algorithms;aspirate;Biological;Biological Assay;Blood specimen;Blood Specimen Collection;bone;bone cell;bone imaging;Bone Marrow;Bone Marrow Aspiration;Bone marrow biopsy;cell free DNA;Cells;Cessation of life;Chemicals;Clinical;clinical decision-making;Clinical Trials;Complement;Data;demethylation;Detection;Diagnosis;Disease;DNA;Drug Combinations;Early Diagnosis;epidemiology study;Epigenetic Process;Evaluation;Extramedullary;Flow Cytometry;fluorodeoxyglucose positron emission tomography;Genome Mappings;genome-wide;Glycolysis;Goals;Hematologic Neoplasms;Hemodilution;Heterogeneity;high risk;Image;imaging modality;immune modulating agents;improved;In complete remission;Infiltration;insight;International;Knowledge;Label;Leadership;Lesion;liquid biopsy;Measurable;Metabolic;Modality;Modeling;Modernization;Monitor;Morbidity - disease rate;Morphology;mortality;Multiple Myeloma;Neoadjuvant Therapy;neoplastic cell;Newly Diagnosed;next generation sequencing;non-invasive monitor;novel;Observational Study;Oligonucleotides;participant enrollment;Patient Care;patient prognosis;patient response;Patients;Performance;peripheral blood;phase II trial;Plasma;Plasma Cells;Positron-Emission Tomography;prevent;Procedures;Prognostic Marker;prognostication;progression risk;Progression-Free Survivals;prospective;Relapse;Residual Neoplasm;Resolution;Resources;response;Sampling;seal;sex;Specimen;standard of care;Techniques;Testing;Therapeutic;Time;Translating;treatment effect;treatment response;tumor specificity;Tumor Volume;Tumor-Associated Process;United States;Work;working group;X-Ray Computed Tomography

PROJECT_TITLE: Integrating liquid biopsy-based epigenetic and imaging modalities to evaluate disease response in multiple myeloma

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative This project will deliver TADsplit and StripeDiff as a set of novel bioinformatics techniques to investigate dynamic alterations of genome’s 3D architecture. By applying these tools to EndMT, we will reveal complementary role of the insulator protein CTCF and a novel endothelial cell identity gene ITF2 in dynamic regulation of the genome’s 3D architecture.

PI_NAMEs: CHEN, KAIFU  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: 3-Dimensional;Algorithms;Architecture;Benchmarking;Bioinformatics;Biological;Biological Assay;Biological Models;Biological Process;Blood Vessels;C10;Cardiac;Cardiovascular Diseases;CCCTC-binding factor;cell type;Cells;Chromatin;Chromatin Interaction Analysis by Paired-End Tag Sequencing;chromatin modification;chromosome conformation capture;Chromosome Territory;Communities;Data;Detection;Development;Disease;DNA;DNA Repair;Embryonic Development;Endothelial Cells;Endothelium;Enhancers;epigenetic regulation;Feedback;Fibroblasts;Frequencies;Gene Expression;Genes;Genetic Transcription;Genome;Genomics;Hi-C;human disease;improved;indexing;Individual;Inflammatory;insight;Investigation;Length;Location;Malignant - descriptor;Measures;Mesenchymal;Methods;Modeling;Molecular;novel;Outcome;Pathogenesis;Pattern;Performance;Play;Regulation;Reporting;Research Personnel;Resolution;Role;Sampling;Scientist;Site;Statistical Models;Techniques;Technology;tool;transcription factor;Transcriptional Regulation;Variant;Width;Work

PROJECT_TITLE: Bioinformatics Techniques to Analyze Dynamic Changes of 3D Genome

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic malignancy in children and young adults that frequently becomes treatment-refractory and relapses. This project seeks to define novel mechanisms of immune evasion in T-ALL. It will lead to development of novel and transformative therapeutic strategies through targeting T-cell exhaustion for patients with high-risk T-ALL.

PI_NAMEs: KNOECHEL, BIRGIT  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: 3-Dimensional;Acute T Cell Leukemia;Address;B-Cell Acute Lymphoblastic Leukemia;Blood;CD19 gene;CD8-Positive T-Lymphocytes;Cell Communication;Cells;chemotherapy;Child;Childhood Leukemia;Chromatin;Chromosomes;Clinical;CRISPR screen;CRISPR/Cas technology;Data;Development;engineered T cells;Enhancers;EP300 gene;Epigenetic Process;exhaust;exhaustion;experimental study;Functional disorder;Galactose Binding Lectin;Generations;Genetic;Genetic Transcription;genome editing;genome-wide;Hematopoietic Neoplasms;high risk;Human;Immune;Immune Evasion;Immune Targeting;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo Model;inhibitor;innovation;Kinetics;Large-Scale Sequencing;leukemia;Ligand Binding;Ligands;Malignant lymphoid neoplasm;Malignant Neoplasms;Manuscripts;Maps;Medical;Menin;Molecular;Molecular Conformation;mouse model;Myeloproliferative disease;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Oncogenic;Pathway interactions;Patients;Prognosis;Protein Analysis;receptor;Refractory;Refractory Disease;Relapse;Research;resistance mechanism;response;Role;Sampling;single cell sequencing;Solid Neoplasm;Subgroup;success;T cell response;T cell therapy;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;transcription factor;transcriptome sequencing;Treatment Protocols;treatment strategy;tumor-immune system interactions;young adult

PROJECT_TITLE: Mechanisms of immune evasion in T-cell acute lymphoblastic leukemia and its therapeutic implications

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Genetics;Human Genome;Immunization;Lupus;Vaccine Related

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: NARRATIVE The autoimmune disorder systemic lupus erythematosus (SLE) affects as many as 1.5 million Americans, the majority of which are young women of color, and available treatments do not effectively control SLE morbidity and mortality. SLE is inherited, and we have used a combination of genetics and functional studies to identify HIPK1, an enzyme previously studied in the context of cancer, as a potential regulator of lupus susceptibility. The work proposed will establish decisively whether HIPK1 is involved in the development of SLE, and whether drugs that modulate HIPK1 activity represent a new therapeutic approach for management of this significant human health problem.

PI_NAMEs: WELLS, ANDREW D (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: 3-Dimensional;adaptive immunity;Affect;Affinity;American;Antibodies;Antibody Formation;Antibody Response;antigen-specific T cells;Antigens;Autoantibodies;Autoimmune Diseases;Autoimmunity;autoinflammatory diseases;B cell differentiation;B-Lymphocytes;BCL6 gene;Biology;Blood;BLR1 gene;Cell Lineage;Cell Nucleus;cell type;Cells;Chickens;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Collaborations;Communicable Diseases;cytokine;Development;Disease;Drug Modulation;Drug Targeting;efficacy study;Enzymes;Foundations;Functional disorder;Future;gain of function;Generations;Genes;Genetic;Genetic Polymorphism;Genetic study;Genetic Variation;Genome;genome wide association study;Genomics;Health;Helper-Inducer T-Lymphocyte;high risk;Homeostasis;Human;human model;Humoral Immunities;IL7R gene;Immune;Immune response;Immunity;Immunization;Immunoglobulin Class Switching;Immunomodulators;Immunophenotyping;immunoregulation;In Vitro;in vivo;Infection;Inflammation;Inherited;insight;interleukin-21;Knockout Mice;loss of function;LoxP-flanked allele;Lupus;Lymphocyte;Lymphoid;Malignant Neoplasms;Maps;Mediating;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutation;novel;novel therapeutic intervention;Organoids;Outcome;Outcome Study;Ovalbumin;Patients;pediatric patients;pharmacologic;Pharmacology Study;Phosphotransferases;Predisposition;Production;programmed cell death protein 1;Publishing;Regulation;Regulatory Element;response;Role;Series;single-cell RNA sequencing;Structure of germinal center of lymph node;System;systemic autoimmune disease;systemic inflammatory response;Systemic Lupus Erythematosus;T cell differentiation;T cell regulation;T-Cell Development;T-Lymphocyte;Testing;three dimensional structure;TLR7 gene;Tonsil;transcriptomics;Untranslated RNA;Vaccination;Vaccines;Variant;variant of unknown significance;women of color;Women's mortality;Work;young woman

PROJECT_TITLE: HIPK1: a new immunomodulatory target for SLE

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: LITTLETON

ORG_NAME: AMERICAN ASSOCIATION OF NEUROPATHOLOGISTS, INC.

ORG_STATE: CO

PHR: Project Narrative  There is a national mandate to cure or prevent Alzheimer’s disease and related dementias by 2025, a task which will require the education and supporting of neuropathology trainees interested in academic research careers. This R13 application is to support a pre-meeting workshop for neuropathology trainees at the Annual Meeting of the American Association of Neuropathologists (AANP).

PI_NAMEs: LEE, EDWARD BYUNG-HA (contact)

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: Academia;Academic Medical Centers;Address;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Applications Grants;Award;Awareness;career;career development;Clinical;cohort;Communities;cost;Dedications;Development;Education;Educational process of instructing;Educational workshop;expectation;Faculty;Fellowship;Funding;Goals;Grant;Incentives;interest;Investments;Lead;Longitudinal Surveys;meetings;member;Monitor;Neurodegenerative Disorders;neuropathology;next generation;North America;Outcome;Positioning Attribute;Postdoctoral Fellow;prevent;Prevention;Process;Professional Organizations;programs;Publishing;Recommendation;Recording of previous events;Recurrence;Research;Residencies;Resources;Route;Scholars Program;Scientific Societies;Structure;success;symposium;Training;Travel;Underrepresented Minority;United States;United States National Institutes of Health;Woman;Writing

PROJECT_TITLE: AANP Scholars' Workshop on Neurodegenerative Disease Neuropathology Research

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Cancer

ORG_CITY: FAYETTEVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: Project Narrative Cellular mechanical properties such as contractility play key roles in development and are often altered in diseases, thus targeting the altered mechanical properties of cells holds great potential. However, diseased cells often exhibit different mechanical phenotypes and can switch between these different phenotypes during disease progression, which allows them to resist and escape therapeutic targeting. This project develops an engineered high-throughput platform to isolate and characterize mechanically distinct cell subgroups based on cellular contractility, thus providing a versatile tool to understand the effect of distinct mechanical phenotypes on the progression of human diseases such as cancer.

PI_NAMEs: ZHANG, JIAN  (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Actomyosin;Adopted;Aging;Attention;Biological;Biological Models;Breast Cancer Cell;Cardiovascular Diseases;Cell Line;cell motility;Cell Separation;Cells;Coupled;Cultured Cells;Defect;design;Development;Disease;Disease Outcome;Disease Progression;Engineering;Environment;Exhibits;experimental study;extracellular;Fibrosis;Fluorescence-Activated Cell Sorting;Foundations;Future;Genetic Heterogeneity;Geometry;Goals;Heterogeneity;high throughput screening;human disease;In Vitro;in vivo;Individual;innovation;Invaded;Knowledge;Label;Malignant Neoplasms;mechanical properties;Mechanics;mechanotransduction;Memory;Mesenchymal Stem Cells;Metabolism;Metastatic breast cancer;Methods;Microscopy;migration;Modeling;Molecular;mouse model;Mus;Neoplasm Metastasis;novel;Organ;Outcome;Output;Pathway interactions;Pattern;Phenotype;photoactivation;Play;Population;population based;Postdoctoral Fellow;Primary Neoplasm;Process;Proliferating;Proteins;Reporting;Research;Role;screening;Signal Transduction;Sorting;Source;spatiotemporal;stem cell population;Subgroup;Surface;System;targeted treatment;Testing;therapeutic target;therapy resistant;Time;Tissues;tool;Traction;Traction Force Microscopy;tumor;tumor progression;Work

PROJECT_TITLE: Sorting and characterization of mechanically heterogeneous cell populations based on cellular contractility

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Human Genome;Regenerative Medicine

ORG_CITY: BOSTON

PHR: PROJECT NARRATIVE Reprogramming B cells to produce therapeutic antibodies or other transgenes could provide new treatments for infectious and genetic diseases. The current methods for B cell engineering, however, use nucleases like CRISPR/Cas which have potential safety issues, and require first removing B cells from the patient, which is very expensive. Here we explore a potential strategy for editing B cells without the need for nucleases, improving safety, while using a well established, one-size-fits all gene therapy system, thereby reducing cost.

PI_NAMEs: FARZAN, MICHAEL R. (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Address;adeno-associated viral vector;Affinity;Animals;Antibodies;antibody test;Antigens;Apoptosis;arm;Automobile Driving;B-Cell Antigen Receptor;B-Lymphocytes;base editing;Biological Assay;Biological Products;Cell Survival;Cells;cellular engineering;cellular transduction;chimeric antigen receptor T cells;Chromosome abnormality;Chromosome Deletion;Clustered Regularly Interspaced Short Palindromic Repeats;Consumption;cost;cost effective;COVID-19 vaccine;Dangerousness;Deletion Mutagenesis;design;DNA;DNA cassette;Dose;Elements;endonuclease;Engraftment;Enzyme-Linked Immunosorbent Assay;Erythropoietin;Erythropoietin Receptor;Event;Exhibits;exome;experimental study;gene therapy;Gene Transduction Agent;Genes;Genetic;Genetic Diseases;genetic element;Genome-wide Unbiased Identification of DSBs Enabled by sequencing;Goals;Hematocrit procedure;HIV;HIV envelope protein;Human;Immunoglobulin Class Switching;Immunoglobulin Somatic Hypermutation;improved;in vivo;infectious disease treatment;Infusion procedures;Insertional Mutagenesis;interest;Intravenous infusion procedures;Introns;Inverted Terminal Repeat;Lesion;Measures;Membrane;Methods;Modeling;Monitor;mRNA delivery;Mus;Neoplastic Cell Transformation;neutralizing antibody;nuclease;Pathway interactions;Patients;Physiological;Privatization;Proliferating;Protocols documentation;Reagent;Recombinant adeno-associated virus (rAAV);Recombinant Antibody;Recombinants;repaired;Research Personnel;response;retroviral transduction;Retroviridae;Risk;Safety;Serotyping;Serum;Sorting;System;Techniques;Terminal Repeat Sequences;Testing;Therapeutic;Therapeutic antibodies;therapeutic genome editing;TP53 gene;Transcript;transgene expression;Transgenes;Vaccinated;Vaccination

PROJECT_TITLE: Safe, CRISPR/Cas-free B cell editing for therapeutic applications

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: GENETICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE  In addition to genetic driver mutations, activation of emergency myelopoiesis pathways in leukemic HSPCs contribute to the development of myeloid malignancies. The lack of a comprehensive understanding of how the specific biology and underlying molecular regulation of emergency myelopoiesis are altered in different leukemic contexts represents one of the major barriers to developing new therapeutics to treat myeloid maligan- cies. The overall goal of this project is to identify the transcriptional, epigenetic and metabolic mechanisms con- trolling emergency myelopoiesis and driving the overproduction of blast cells and clonal dominance of malignant HSPCs.

PI_NAMEs: PASSEGUE, EMMANUELLE  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute stress;Address;alpha ketoglutarate;Atlases;Automobile Driving;bcr-abl Fusion Proteins;beta catenin;biological adaptation to stress;Biological Assay;Biology;Blast Cell;Blood;Bone Marrow;Bone Marrow Purging;Cell Compartmentation;Cells;Chromatin;Chronic Myeloid Leukemia;Comparative Study;Complex;Consumption;CSF3 gene;cytokine;Dependence;Development;Disadvantaged;Disease;Disease Progression;driver mutation;Emergency Situation;Enzymes;Epigenetic Process;epigenetic regulation;FLT3 gene;Fluorouracil;Generations;Genes;Genetic;Genetic Transcription;Goals;granulocyte;hematopoietic stem cell quiescence;Hematopoietic stem cells;Impairment;improved;Inflammation;Inflammatory;insight;Interleukin-1;Interleukin-6;Investigation;Laboratories;leukemia;leukemia treatment;Leukemic Hematopoietic Stem Cell;leukemic stem cell;Lymphoid;Lymphopoiesis;Macrophage;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mediating;Megakaryocytes;Metabolic;metabolomics;mitochondrial metabolism;Modeling;Molecular;mouse model;MPP2 gene;MPP3 gene;Multipotent Stem Cells;Myelofibrosis;Myelogenous;Myeloid Cells;Myeloid Leukemia;Myelopoiesis;Myeloproliferative disease;Natural regeneration;notch protein;novel;novel strategies;novel therapeutics;osteoprogenitor cell;Output;Pathogenesis;Pathway interactions;Patients;Phase;Play;Preleukemia;prevent;Process;Production;progenitor;programs;Property;Proto-Oncogene Proteins c-myc;regenerative;Regulation;response;Role;self-renewal;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;stem cell differentiation;stem cell expansion;stem cell function;stem cell population;targeted treatment;Testing;TNF gene;Transforming Growth Factor beta;Transplantation;Work

PROJECT_TITLE: Emergency Myelopoiesis in the Pathogenesis of Myeloid Malignancies

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Genetics

ORG_CITY: STONY BROOK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: NARRAVTIVE The translational machinery is a major target of current antibiotics. However, the need for new counter measures has become even more urgent with the rise of multi-drug resistant bacteria and a severe shortage of new antibiotics. Our proposed studies of translation quality control mechanisms in bacteria offer the opportunity to gain novel insights and a deeper mechanistic understanding of a unique bacterial surveillance system mediated by tmRNA and its protein co-factors. A systematic understanding of this extraordinary bacterial system, essential for survival and virulence of many pathogenic bacteria, should pave the way for future development of novel antibiotics and improving current antibiotic treatment.

PI_NAMEs: KARZAI, A. WALI  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Adaptor Signaling Protein;Antibiotic Therapy;Antibiotics;Bacteria;Binding Sites;Biochemical;Biogenesis;C-terminal;cofactor;Crowding;Cytoplasm;Data;Defect;design;Development;endopeptidase La;enhancing factor;Enzymes;Eukaryota;Exoribonucleases;Family;fitness;Future;Genetic;Goals;improved;insight;Knowledge;Light;Link;Location;Measures;Mediating;member;Messenger RNA;Modeling;Modification;Molecular;mRNA Decay;Multiple Bacterial Drug Resistance;novel;Participant;Pathogenesis;pathogenic bacteria;Pathway interactions;Peptide Hydrolases;Play;polyglutamate;polypeptide;Positioning Attribute;Process;Protein Biosynthesis;Proteins;Proteolysis;Quality Control;recruit;Recycling;Regulatory Pathway;Research Project Grants;ribonuclease R;Ribonucleases;Ribosomal Protein S6;Ribosomes;RNA;Role;Site;Specificity;System;Testing;tmRNA;Transcript;Translating;Translation Process;Translations;Virulence

PROJECT_TITLE: Quality Control Mechanisms in Protein Synthesis

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Cancer-causing oncogenes are controlled by stretches of DNA called promoters and enhancers, which loop together in complex patterns in 3D space to control expression of genes. Understanding how enhancers and promoters work together to regulate oncogenes will not only help us understand the basic biology of how gene regulation occurs, but will also help us to understand how specific enhancer variants carried by individuals may contribute to their cancer risk. We are employing new CRISPR-based technologies to understand at ultrahigh resolution how oncogene enhancers are co-regulated in multiple types of cancer cells.

PI_NAMEs: QI, LEI STANLEY (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: 3-Dimensional;Architecture;BCL2 gene;biological systems;Biology;cancer cell;Cancer cell line;cancer risk;cancer type;cell type;Cells;Chromatin;Chromatin Structure;clinical risk;Clustered Regularly Interspaced Short Palindromic Repeats;Color;Complex;computer studies;CRISPR interference;CRISPR screen;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Data;design;Disease;disorder risk;Dissection;Distant;DNA;Elements;Engineering;Enhancers;Exhibits;experimental study;GATA4 gene;Gene Expression;Gene Expression Regulation;gene network;Genes;genetic association;Genetic Epistasis;Genetic Predisposition to Disease;Genetic Transcription;genetic variant;Genome;Genome engineering;genome wide association study;Genomic approach;genomic locus;Growth;Guide RNA;Hela Cells;Human Genome;Image;Imaging technology;Individual;IRF1 gene;K-562;K562 Cells;Leukemic Cell;Libraries;live cell imaging;Machine Learning;machine learning model;Malignant Neoplasms;mammalian genome;Maps;Mediating;Mediator;Messenger RNA;Methods;Modeling;MYC gene;Myeloid Leukemia;Oncogenes;Pattern;Penetrance;Phase;Physical condensation;Play;promoter;Promoter Regions;Proteins;real time monitoring;Regulation;Regulatory Element;Resolution;RNA;Role;screening;Single Nucleotide Polymorphism;Stretching;Techniques;Testing;Time;Transcription Coactivator;Translating;ultra high resolution;Untranslated RNA;Variant;virulence gene;Work

PROJECT_TITLE: High resolution dissection of oncogene enhancer networks via CRISPR screening and live-cell imaging.

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ORG_DEPT: ZOOLOGY

PHR: The cells of the developing fetus signal to each other, providing instructions that tell cells which kinds of tissues to form and how quickly and where to grow. We are studying a new type of cell- cell signaling used to control tissue growth and cell arrangement in humans, disruption of which leads to a number of human pathologies including the neurological disorders of Van Maldergem syndrome. Our investigations use the powerful and cost-effective tools provided by a “model” animal, the fruitfly Drosophila melanogaster, where this type of signaling was first discovered.

PI_NAMEs: BLAIR, SETH S (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Adaptor Signaling Protein;Address;Affect;Affinity;Animals;Back;Binding;Binding Proteins;Binding Sites;Biochemistry;C-terminal;casein kinase;Caseins;cell behavior;cell type;Cells;cofactor;cost effective;Data;Defect;Development;Drosophila genus;Drosophila melanogaster;Drosophila Proteins;Epithelial Cells;Epithelium;F Box Domain;Face;Fatty acid glycerol esters;Feedback;Fetal Development;Goals;GOLGA7 gene;Growth;Homologous Gene;Human;Human Genetics;Human Pathology;In Vitro;in vivo;in vivo evaluation;Instruction;intercellular communication;Investigation;Link;Mediating;Mediator;Membrane;Modeling;Modification;Molecular Genetics;mutant;Mutation;Myosin ATPase;Nervous System Disorder;Neurologic;novel;Palmitic Acylation Site;palmitoylation;Pathology;Pathway interactions;Phosphorylation;Phosphorylation Site;Phosphotransferases;planar cell polarity;polarized cell;Proliferating;Proteins;Regulation;Role;Route;scaffold;Scaffolding Protein;SH3 Domains;Signal Pathway;Signal Transduction;Structure;Surface;Syndrome;System;Tail;Tertiary Protein Structure;Testing;Tissues;tool;transmission process;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Van Maldergem syndrome

PROJECT_TITLE: Regulation and feedback in Fat/Dachsous signaling

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Few culturally tailored, evidence-based interventions exist to improve viral suppression and health outcomes in Latinos with HIV, who are disproportionately affected by the HIV epidemic. Drawing from successful formative work in a NIMH-funded K23 award, we propose a randomized controlled trial of ADELANTE, a community health worker-delivered, telenovela-based intervention to improve problem-solving and link Latino patients with HIV to resources for unmet needs. We will assess ADELANTE’s impact on viral suppression, health care utilization, and other health outcomes in Latinos with HIV.

PI_NAMEs: LEVISON, JULIE  (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: 2 arm randomized control trial;acceptability and feasibility;Acute;Address;Adherence;Affect;Anti-Retroviral Agents;Area;Biometry;Caring;Clinic;Clinical;Clinical effectiveness;Clinical Trials;Communication Tools;community engagement;Community Health Aides;community partnership;Consolidated Framework for Implementation Research;Cultural Diversity;Data;Development;Discrimination;Disparity;Education;Effectiveness;Emergency department visit;empowerment;enhanced care;Ensure;Epidemic;epidemic preparedness;Evidence based intervention;Film;Focus Groups;Fright;Funding;Future;future implementation;Geographic Locations;Geography;Health;health care service utilization;health communication;health disparity;Health Services Accessibility;Health system;HIV;HIV/AIDS;Homophobia;Hospitalization;Immigrant;implementation facilitators;Implementation readiness;improved;improved outcome;Incidence;Individual;intersectionality;Intervention;Intervention Trial;Interview;Language;Latino;Latino Population;Leadership;Link;Massachusetts;Mediating;Mediation;Medicine;Mental disorders;Mental Health;Mentored Patient-Oriented Research Career Development Award;Migrant;Modeling;multidisciplinary;National Institute of Mental Health;Outcome;Participant;Pathway interactions;patient retention;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Poverty;Prevalence;Primary Care;Principal Investigator;Printing;Problem Solving;programs;Provider;Public Health;Randomized;Randomized, Controlled Trials;Reduce health disparities;Research;Research Personnel;Research Support;Resources;RNA;Self Efficacy;Services;Site;social stigma;Social Work;Spanish;Structure;substance use;Technology;Telephone;Testing;theories;therapy design;Time;tool;Training;Transportation;transportation access;Treatment outcome;Underserved Population;United States National Institutes of Health;uptake;Viral;Viral Load result;Well in self;Work

PROJECT_TITLE: ADELANTE: A Randomized Controlled Trial of an Intervention to Improve Engagement in Care for Latinos with HIV

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Aging

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: PROJECT NARRATIVE Aging is accompanied by the gradual deterioration within each individual cellular compartments/organelles as well as the collapse of the interconnections among them, leading to the establishment of different hallmarks of aging. We recently discovered an unexpected crosstalk between mitochondria and the lysosome (vacuole in yeast) that explains age-associated vacuole/lysosome de-acidification and provides a novel interconnection between age-associated mitochondrial dysfunction and lysosome defects that conserved from yeast to human cells and cause many age-related diseases. In this grant, we will integrate the complementary expertise, techniques, and model organisms from multiple labs, including yeast, human cells, and C. elegans, to investigate how aging affects the mitochondria-lysosome/vacuole contact and validate whether this mitochondria-to- lysosome axis plays a critical role in lysosome acidification in cellular senescence and animals during aging and in longevity paradigms in turn leading to new therapeutic targets for many age-related diseases with lysosome defects.

PI_NAMEs: ANDERSEN, JULIE KAY;HANSEN, MALENE ;ZHOU, CHUANKAI  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Address;Affect;Age;age related;age related changes;age related deterioration;age-related disease;Aging;Animals;ATP Synthesis Pathway;Biological Models;Caenorhabditis elegans;Caloric Restriction;cell age;Cell Aging;Cell division;Cells;Charge;Communication;Cytosol;daughter cell;Defect;Deterioration;dietary restriction;Electron Transport;experimental study;extend lifespan;Functional disorder;Future;Grant;hallmarks of aging;healthspan;Heterogeneity;Human;Image;Impairment;improved;in vivo;in vivo Model;Individual;Inner mitochondrial membrane;interest;Laboratories;Link;Longevity;Lysosomes;Mass Spectrum Analysis;Matrix Metalloproteinases;Membrane;Membrane Potentials;Mitochondria;mitochondrial dysfunction;Mitochondrial Matrix;mitochondrial membrane;Mitochondrial Proteins;model organism;Nematoda;new therapeutic target;novel;Organelles;Organism;Phosphorylation;Play;preservation;Process;protein aggregation;Proteins;proteostasis loss;Proton Pump;Protons;Provider;Rejuvenation;Reporting;Role;segregation;senescence;senescent cell;sensor;Sirolimus;Site;Source;Techniques;Testing;Therapeutic;therapeutic target;therapy development;Thinking;Time;Tissues;vacuolar H+-ATPase;Vacuole;Work;Yeasts

PROJECT_TITLE: Novel mitochondria-to-lysosome crosstalk contributes to lysosomal dysfunction during aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-Z(52)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Rare Diseases;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Vascular dysfunction is commonly observed in the small vessel disease, cerebral amyloid angiopathy, and contributes to the neuropathology of Alzheimer’s Disease. Utilizing live-imaging and transcriptional studies in mice, I seek to identify how perivascular fibroblasts support the brain vasculature and how their loss in cerebral amyloid angiopathy contributes to vascular dysfunction. Identifying how perivascular fibroblasts support brain vascular function is crucial to develop therapies that improve vascular function and limit tissue damage in Alzheimer’s Disease.

PI_NAMEs: BONNEY, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Ablation;Acceleration;Address;Adult;Advisory Committees;Affect;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein Precursor;Arteries;arteriole;Astrocytes;awake;Biology;Blood flow;Blood Vessels;Brain;brain health;Calcium;Calcium Signaling;career;Cells;Cerebral Amyloid Angiopathy;cerebrovascular;Cerebrovascular system;Child;Clinical;Clinical Pathology;Communication;Complex;constriction;Coupled;Developmental Biology;Diameter;Disease;Disease Progression;Endothelial Cells;Ensure;Etiology;Event;experience;Extracellular Matrix Proteins;Faculty;Fibroblasts;Functional disorder;Future;Gene Expression Profile;Genes;genetic approach;Genetic Transcription;Goals;Health;Hypercapnia;Image;Impairment;improved;in vivo;in vivo imaging;innovation;Investigation;Knowledge;Life;Mediating;Mentorship;Methods;Microvascular Dysfunction;Modeling;mouse model;Mus;Mutation;neuropathology;neurovascular;neurovascular coupling;Optics;Pathology;Pathway interactions;Peptide Initiation Factors;Pericytes;Phase;Physiology;Population;Regenerative Medicine;Reporter;Reporting;Research;Research Institute;Role;Running;skills;Smooth Muscle Myocytes;Structure;Techniques;Testing;Tg2576;Therapeutic;therapy development;Tissues;tool;Training;transcriptomics;Transgenic Organisms;two photon microscopy;Vascular Diseases;vascular factor;vasomotion;venule;wasting

PROJECT_TITLE: Exploring brain perivascular fibroblasts in health and cerebral amyloid angiopathy

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Sleep Research;Social Determinants of Health

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: Project Narrative Chronic social isolation induces detrimental health effects by altering health-critical behaviors. In this proposed study, we plan to elucidate the genetic, molecular, and cellular pathways underlying the timekeeping mechanisms during chronic social isolation and investigate how chronic social isolation alters metabolism. The study will provide novel insights into social isolation, chronic stress, timekeeping mechanisms, fundamental behaviors, and metabolism at the intersection of genetics, biological timing, and molecular biology.

PI_NAMEs: LI, WANHE  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Acute;Address;Affect;Animal Behavior;Animals;Behavior;behavior change;behavior measurement;Behavioral;behavioral outcome;Biological;Biological Models;Biology;Brain;Cells;Chronic;Chronic stress;circadian pacemaker;COVID-19 pandemic;Disease;Dissection;Drosophila melanogaster;Eating Disorders;Functional Imaging;Genetic;Goals;Health;Hunger;Hyperphagia;innovation;insight;interdisciplinary approach;Interdisciplinary Study;Intervention;Mediating;Metabolism;metabolomics;Modeling;Molecular;Molecular Biology;Nature;neurogenetics;novel;novel strategies;Pathway interactions;Physiological;Physiology;Population;Problem behavior;Process;Research;Resolution;Signal Transduction;Sleep;Sleep Deprivation;Sleep disturbances;Social Environment;Social Interaction;Social isolation;Social Perception;Social status;Time;transcriptomic profiling

PROJECT_TITLE: Interdisciplinary Studies for Mechanisms Underlying Social Isolation-Induced Health Critical Behavior Changes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-L(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Traumatic brain injury may accelerate the development of Alzheimer’s disease, yet its underlying mechanisms are not fully understood. Here I address this unmet need by investigating trauma-induced hippocampal microvascular injury using advanced neuroimaging methods, including brain MRI and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) imaging. My goal is to explore the role of hippocampal blood-brain barrier leakage in the acceleration of amyloid-beta and phosphorylated-tau pathology, white matter degeneration, as well as memory deficits.

PI_NAMEs: HUA, NING  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;Ablation;Acceleration;Address;Advisory Committees;age related;aging brain;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;Atherosclerosis;Attention;Attenuated;Biology;Biophysics;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier disruption;blood-brain barrier permeabilization;Boston;Brain;Brain Injuries;brain magnetic resonance imaging;Brain region;Calibration;Cardiovascular system;career;Career Choice;Career Mobility;Clinical;contrast enhanced;Dementia;Development;Diagnosis;Diagnostic;Diffusion Magnetic Resonance Imaging;Disease Progression;Doctor of Philosophy;early onset;Economic Burden;Environment;experimental study;Extravasation;Faculty;Foundations;Funding;Goals;head impact;Health;high risk;hippocampal atrophy;Hippocampal Formation;hippocampal subregions;Hippocampus;hyperphosphorylated tau;imaging biomarker;Imaging Techniques;improved;in vivo;Inductively Coupled Plasma Mass Spectrometry;Injury;invention;Investigation;Knowledge;Lasers;Learning;Link;Liquid substance;Magnetic Resonance Imaging;mass spectrometric imaging;Measurement;Measures;mechanical load;medical schools;Memory;Memory impairment;Memory Loss;Mentored Research Scientist Development Award;Mentors;Methods;Microvascular Dysfunction;Mission;mouse model;Nervous System Trauma;Neurodegenerative Disorders;neuroimaging;neuroimaging marker;neurovascular;novel;Outcome;Pathology;Performance;Permeability;Play;Positioning Attribute;Predisposition;professor;Radiology Specialty;Recovery;Research;Research Activity;Research Personnel;Resolution;Resources;Risk;Risk Factors;Role;Scientist;skills;Societies;Specific qualifier value;Stress;Structure;System;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic;therapeutically effective;Time;Training;Training Activity;Transgenic Mice;Trauma;Trauma patient;Traumatic Brain Injury;United States National Institutes of Health;Universities;vascular injury;white matter;Work

PROJECT_TITLE: Microvascular Neuroimaging in Age-related Alzheimer's Disease and Tauopathies

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]