NIH_SPENDING_CATS: Diabetes;Infectious Diseases;Wound Healing and Care

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: Impaired infection control against pathogenic bacteria is major co-morbidity that contributes to impaired healing in diabetic wounds. The goals of this project are to determine why diabetic wounds fail to control infection with pathogenic bacteria and use novel therapeutic approaches to treat infections and stimulate wound healing in diabetic wounds.

PI_NAMEs: AMEER, GUILLERMO ANTONIO;SHAFIKHANI, SASHA H (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acute;Address;Allergic Reaction;Amputation;Animal Model;Animals;Antibiotic Resistance;Antibiotics;antimicrobial;autocrine;Bacteria;bactericide;Biological;Biological Products;Biological Response Modifier Therapy;CCL3 gene;CCR1 gene;chemokine;chemokine receptor;Chemotaxis;chronic ulcer;Clinical;cohort;combat;comorbidity;Complications of Diabetes Mellitus;conventional therapy;cytotoxicity;Data;db/db mouse;Development;diabetes management;diabetic;Diabetic Foot Ulcer;Diabetic mouse;diabetic patient;diabetic ulcer;Dose;drug development;efficacy evaluation;Family suidae;fMet-Leu-Phe receptor;Food and Drug Administration Drug Approval;formyl peptide;FPR1 gene;Functional impairment;Gel;Glucose;Goals;healing;Hospitalization;Human;Immune System Diseases;Impaired healing;Impairment;improved;Infection;Infection Control;Inflammation;Inflammatory;Inflammatory Response;Injury;insight;Interleukin-10;Invaded;Investigation;Investigational Drugs;Leukocyte Trafficking;Leukocytes;Ligands;Lower Extremity;Macrophage;Mediating;Metabolic syndrome;Molecular;monocyte;Mus;Nervous System Disorder;neutrophil;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Occupations;Outcome;Paracrine Communication;pathogen;pathogenic bacteria;Phagocytes;Phase;Phase II Clinical Trials;Play;porcine model;preclinical efficacy;Predisposition;Pseudomonas aeruginosa;Publications;Publishing;receptor;recruit;regenerative;response;Role;Safety;safety assessment;side effect;Signal Transduction;Staphylococcus aureus;STAT3 gene;Testing;Therapeutic;Topical application;Toxic effect;trafficking;United States Food and Drug Administration;wound;wound care;wound dressing;wound healing;Wound models;wound treatment

PROJECT_TITLE: Assessment of CCL3 Therapy in Diabetic Wound Care

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: ATHENS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE Licensed flu vaccines suffer from loss of protection due to antigenic drift, lack of cross protection of zoonotic viruses, and poor immune responses in populations at greatest risk of complications from infection. We propose to develop a next generation flu vaccine that will provide broad and durable protection by chemically synthesizing compounds composed of cross-reactive T- and B-epitopes and an in-built immuno adjuvant. This research directly addresses goals in the NIAID strategic plan for developing a universal influenza vaccine and will provide candidate universal influenza vaccines as well as novel vaccine designs and adjuvants for other vaccine applications.

PI_NAMEs: BOONS, GEERT-JAN  (contact);TOMPKINS, STEPHEN MARK

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: Address;Adjuvant;Agonist;Animal Model;Antibodies;Antigens;Area;B-Lymphocytes;Biological Assay;burden of illness;Cancer Model;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cessation of life;chemical synthesis;Chemicals;Chemistry;cost effective measures;cross immunity;cross reactivity;design;Disease;Elderly;Epitopes;expectation;Ferrets;Glycoconjugates;Glycoengineering;Glycopeptides;Glycoproteins;Goals;Health;Hemagglutinin;Human;human model;Immune;Immune response;Immunity;Immunocompromised Host;immunogenic;immunogenicity;Immunologic Adjuvants;Immunologics;Individual;Infant;Infection;Influenza;Influenza A virus;influenza infection;Influenza prevention;Influenza vaccination;influenza virus vaccine;influenzavirus;innovation;Integral Membrane Protein;interest;Licensing;Link;Lipid A;Measures;Mediating;Methodology;Methods;Modeling;Mus;National Institute of Allergy and Infectious Disease;new technology;next generation;novel;novel vaccines;Obesity;pandemic disease;pandemic potential;Peptides;Polysaccharides;Population;Pre-Clinical Model;preclinical study;Proteins;Recombinants;Research;response;Risk;seasonal influenza;Seasons;Serology;Serology test;skills;Strategic Planning;success;Surface Antigens;Synthetic Vaccines;T cell response;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;TLR2 gene;tumor;universal influenza vaccine;Update;Vaccination;vaccination strategy;vaccine access;Vaccine Adjuvant;vaccine candidate;Vaccine Design;vaccine development;vaccine efficacy;Vaccines;Virus;Virus Diseases;Zoonoses

PROJECT_TITLE: Synthetic multi-component influenza vaccines to elicit broad immunity

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Orphan Drug;Radiation Oncology;Rare Diseases;Skin Cancer

ORG_CITY: DAYTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WRIGHT STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE This study aims to delineate the specific mechanism(s) by which TIP60-mediated acetylation stabilizes ΔNp63α levels and modulates the DNA damage response, apoptosis, therapeutic resistance and squamous cell carcinoma (SCC) tumor progression using a combination of in vitro and in vivo models. This study is relevant to public health because it will provide (1) a mechanistic insight into the development of resistance to standard treatment modalities for SCC, (2) identify novel therapeutic targets in SCC with elevated TIP60 and ΔNp63α, and (3) assess the efficacy of TIP60 inhibition in sensitizing patient-derived (PDX) cisplatin-resistant head and neck SCC tumors to cisplatin and IR therapy. Thus, the proposed research is relevant to the NIH’s mission pertaining to the pursuit of fundamental knowledge to enhance health and reduce disability, and specifically to support of research into the mechanism of action of cancer therapeutic agents in both in vitro and in vivo model systems and the identification and validation of new druggable targets.

PI_NAMEs: KADAKIA, MADHAVI P (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acetylation;Acetyltransferase;Apoptosis;Biological Models;Carcinoma;Cell Cycle Arrest;Cell Cycle Regulation;Cell Line;Cell Proliferation;Cells;Cervix Uteri;Cessation of life;chemoradiation;Chemoresistance;chemotherapy;Chemotherapy and/or radiation;ChIP-seq;Cisplatin;cisplatin-DNA adduct;clinically relevant;clinically significant;Combination Drug Therapy;Combined Modality Therapy;Cytoplasm;Data;Death Rate;defined contribution;Diagnosis;disability;DNA Damage;DNA metabolism;effectiveness evaluation;efficacy evaluation;efficacy study;Etiology;Failure;FBXW7 gene;gain of function;Genes;Genetic Transcription;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Health;histone acetyltransferase;HTATIP gene;Immunotherapy;improved;In Vitro;in vivo;in vivo Model;Individual;Induction of Apoptosis;inhibitor;insight;Ionizing radiation;knock-down;Knowledge;loss of function;Lung;Lung Carcinoma;M cell;Malignant Neoplasms;MDM2 gene;Mediating;Mediator;Melanoma;Mission;Modality;Modeling;Molecular Chaperones;Morbidity - disease rate;Nasopharynx Carcinoma;new therapeutic target;novel;novel therapeutics;Oncogenic;overexpression;Pathway interactions;patient derived xenograft model;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Prognosis;Proliferating;Proteins;Proto-Oncogenes;Public Health;Publishing;Radiation therapy;Recurrence;Recurrent disease;Recurrent tumor;Regulation;Reporting;Research;Research Support;Resistance;Resistance development;response;Role;Signal Transduction;Site;skin squamous cell carcinoma;Squamous cell carcinoma;standard care;standard of care;Testing;Therapeutic;Therapeutic Agents;therapeutic target;therapy resistant;Transcriptional Regulation;transcriptome sequencing;treatment response;treatment strategy;tumor;tumor growth;tumor progression;tumor xenograft;ubiquitin-protein ligase;Ubiquitination;United States National Institutes of Health;Validation;Xenograft Model

PROJECT_TITLE: Role of DeltaNp63 alpha and TIP60 in SCC progression and chemoresistance

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Depression affects half of those suffering from Parkinson's disease (PD) and is associated with reduced quality of life and accelerated disease progression, however, traditional antidepressants are ineffective in PD. We will combine PET and MR imaging to identify synaptic deficits and network alterations that are distinct to depression in PD, which could represent important new treatment targets. We will also examine the mechanistic effects of ketamine in PD for the first time – to establish its ability to target synaptic and network-level deficits, which could help pave the way for the use of ketamine and other synaptic-enhancing interventions as novel and effective treatments for depression in PD.

PI_NAMEs: HOLMES, SOPHIE  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Acceleration;accurate diagnosis;Adrenergic Agents;Affect;alpha synuclein;Anesthetics;anti-depressive agents;Binding;Brain Stem;Data;density;disability;Disease Progression;Dose;Early Diagnosis;Early Intervention;effective therapy;Exhibits;Functional disorder;Functional Magnetic Resonance Imaging;Hour;Human;Image;in vivo;Individual;individualized medicine;innovation;Intervention;Ketamine;Lewy Bodies;Lewy body pathology;locus ceruleus structure;Magnetic Resonance Imaging;Major Depressive Disorder;Measures;Mental Depression;Moods;Motor;motor symptom;Movement;network dysfunction;neural;neural circuit;Neuroanatomy;novel;Parkinson Disease;Pathology;Pathway interactions;Pattern;Pharmacological Treatment;Phase;Placebos;Positron-Emission Tomography;Prefrontal Cortex;Prevention strategy;programmed cell death protein 1;Proteins;Quality of life;radioligand;response;Secondary to;Severities;Substantia nigra structure;Synapses;Therapeutic;Time;translational impact;treatment strategy;Work

PROJECT_TITLE: Identifying and targeting the neural basis of depression in Parkinson's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-W (92)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Genetics;Human Genome;Mental Health;Mental Illness;Prevention;Serious Mental Illness;Suicide;Violence Research

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Suicide is one of the top ten leading causes of death in the United States, and results in over 700,000 preventable deaths per year worldwide, while the numbers who attempt suicide or have suicidal thoughts are many folds higher. All of these suicide outcomes are known to have strong genetic underpinnings, however, large gaps remain in our understanding of specific genetic or biological risk factors. This project will conduct a comprehensive investigation of the genetic risk factors for suicide attempt, death and ideation through worldwide collaboration, in the Suicide Working Group of the Psychiatric Genomics Consortium.

PI_NAMEs: MULLINS, NIAMH  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Address;Advisory Committees;Affect;American;biobank;Biological;Biology;brain cell;brain tissue;causal variant;Cause of Death;cell type;Cessation of life;Clinical;cohort;Collaborations;Communities;Coroner;Data;data infrastructure;data resource;Death Records;diverse data;Drug Targeting;Ensure;Environmental Exposure;epigenomics;Etiology;Feeling suicidal;Funding;Future;Generations;Genetic;genetic association;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Genetic study;genome wide association study;genome-wide;Genomics;Grant;Growth;Heritability;ideation;improved;Individual;Infrastructure;insight;Intake;International;International Classification of Disease Codes;Intervention;Interview;Investigation;Knowledge;laboratory experiment;Letters;Life;Link;Major Depressive Disorder;Maps;Mediating;Medical Examiners;Medical Records;Mental disorders;National Institute of Mental Health;novel;Outcome;outreach;Pathway interactions;Phenotype;Population;Prevalence;preventable death;Prevention;programs;Protocols documentation;psychiatric genomics;Psychopathology;Publishing;Quantitative Trait Loci;Questionnaires;Research;Resources;Risk Factors;risk prediction;risk stratification;risk variant;Sample Size;Sampling;suicidal;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide rate;Therapeutic;Tissues;tool;United States;Veterans;Work;working group

PROJECT_TITLE: Establishing the Suicide Working Group of the Psychiatric Genomics Consortium to elucidate the genetics and biology of suicide outcomes

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Digestive Diseases;Gene Therapy;Genetics;Intellectual and Developmental Disabilities (IDD);Liver Disease;Nutrition;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Phenylketonuria (PKU) is an inherited disorder in which mutations in the phenylalanine hydroxylase (PAH) gene causes a buildup of the amino acid phenylalanine in the body and, as a result, a variety of serious medical problems. The most common PAH mutation identified in PKU patients, the R408W mutation, does not respond to a standard medical therapy. We seek to use two types of CRISPR gene editing technology, called base editing and prime editing, to directly and permanently correct the R408W mutation at the DNA level in the liver, a strategy that could potentially cure a large number of PKU patients.

PI_NAMEs: WANG, XIAO  (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Address;Adenine;adeno-associated viral vector;Amino Acids;autosome;base editing;base editor;Chromosome abnormality;Chromosomes;chromothripsis;Classical phenylketonuria;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;cognitive development;CRISPR/Cas technology;curative treatments;Cytosine;Diet;Dietary Intervention;Disease;disease-causing mutation;DNA;DNA Modification Process;efficacy evaluation;Enzymes;experience;gene editing technology;Genes;genetic variant;Genetic Variation;genome editing;Guide RNA;Hepatocyte;hepatoma cell;Hereditary Disease;Human;Human Genetics;humanized mouse;Impaired cognition;In Vitro;in vivo;in vivo Model;Injectable;lipid nanoparticle;Liver;Medical;Methods;minimal risk;Modality;mouse model;Mutation;neuropsychiatry;neurotoxic;nonhuman primate;novel;novel therapeutics;nuclease;Oligonucleotides;Oral;Pathogenicity;Patients;Pharmaceutical Preparations;Phenylalanine;Phenylalanine Hydroxylase;Phenylketonurias;prime editing;prime editor;response;Safety;success;System;Therapeutic;therapeutic genome editing;Variant;Work

PROJECT_TITLE: Corrective editing to treat phenylketonuria

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Childhood Injury;Pediatric;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation;Unintentional Childhood Injury

ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative In this project, the investigators study the role of growth plate stem cells in hopes of gaining insights in the skeletal repair process after physeal injury. The results of the study will help bioengineering efforts directed towards growth plate cartilage regeneration.

PI_NAMEs: IONESCU, ANDREIA M. (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Ablation;Adolescent;Adult;Affect;Antibodies;Arthritis;Autologous Stem Cell Transplantation;Autologous Transplantation;Biological Assay;Biomedical Engineering;bone;bone cell;bone fracture repair;Capital;Cartilage;cartilage regeneration;cartilage repair;Cell Differentiation process;Cell Line;Cell Transplantation;cell type;Cells;Child;Chondrocytes;Colony-forming units;Colony-Forming Units Assay;Defect;Deformity;Development;Diphtheria Toxin;disability;Disease;Engraftment;Epiphysial cartilage;Equilibrium;Femur;femur head;Fracture;Growth;healing;Hip Joint;Hip region structure;Hyaline Cartilage;Immunohistochemistry;In Vitro;in vivo;Infiltration;injured;Injury;insight;Leg Length Inequality;Lesion;Limb structure;Literature;Longevity;Maps;matrigel;Mesenchymal;Mesenchymal Stem Cells;Metaphysis;migration;Monitor;Morbidity - disease rate;Mus;Natural regeneration;Neck;Needles;neutralizing antibody;novel therapeutic intervention;Operative Surgical Procedures;Osteogenesis;osteoprogenitor cell;Pain;parathyroid hormone-related protein;Pattern;Physiologic pulse;Population;prevent;Process;progenitor;Property;Protein Isoforms;reconstitution;repaired;Research Personnel;response;response to injury;rib bone structure;Role;self-renewal;Signal Transduction;Site;skeletal;skeletal stem cell;Stains;stem cell expansion;stem cell migration;stem cells;stemness;Surgical Models;Testing;Therapeutic;tibia;Time;timeline;transcriptomics;Transforming Growth Factor beta;Transplantation;wound

PROJECT_TITLE: Growth plate cartilage stem cells for skeletal repair after injury

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Infectious Diseases;Pediatric

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This project proposes to leverage large-scale sample collection that was conducted during an existing cluster- randomized trial in order to study the effects of azithromycin mass drug administration on antimicrobial resistance, including long-term effects, spillover effects to untreated groups, and co-selection of resistance in non-macrolide classes of antibiotics. The project will use phenotypic methods as well as metagenomic deep sequencing to characterize the nasopharyngeal and gut resistome and microbiome of target and non-target groups. The results of this work will contribute to decision-making by national and international policymakers involved in azithromycin mass administration for child survival and will enhance our understanding of the relationship between antibiotic use and emergence of community antimicrobial resistance.

PI_NAMEs: LIETMAN, THOMAS M;O'BRIEN, KIERAN  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: 12 year old;Address;Africa;Africa South of the Sahara;African;Age;Antibiotics;Antimicrobial Resistance;arm;Azithromycin;Bacterial Antibiotic Resistance;Caregivers;Child;Child Mortality;Cluster randomized trial;Collaborations;Communities;community transmission;Complement;Country;Decision Making;deep sequencing;emerging antimicrobial resistance;Evaluation;Foundations;Funding;Future;Genomic approach;Guidelines;Health;high risk;improved;Infrastructure;International;Intervention;Long-Term Effects;Longitudinal cohort;Macrolide-resistance;Metagenomics;Methods;microbiome;Monitor;Morbidity - disease rate;mortality;Nasopharynx;Niger;novel;Only Child;Outcome;pathogen;Pattern;Periodicals;Pharmaceutical Preparations;Phenotype;Placebos;Policy Maker;Population;pressure;Prevalence;primary endpoint;programs;Randomized;randomized trial;Randomized, Controlled Trials;Rectum;Resistance;resistance mechanism;resistant strain;resistome;respiratory;respiratory pathogen;Risk;Risk Reduction;sample collection;Sample Size;Sampling;Subgroup;Time;Trachoma;transmission process;Work;World Health Organization

PROJECT_TITLE: Résistance Evaluée contre la Vie des Enfants au Niger-Implementation et Recherche (REVENIR). Community antimicrobial resistance after azithromycin distribution: selection, spillover, co-selection

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Gastrointestinal problems are common during wars, and these exert significant adverse effects on the health of service members involved in warfare. Veterans returning home from the Iraq and Afghanistan have reported high rates of comorbidity between post-traumatic stress disorder, depression, and gastrointestinal symptoms. Studies have shown that repeated stress induces gastrointestinal symptoms, such as diarrhea, constipation, and dysregulation of the gut microorganism, confirming a potential link between stress and gastrointestinal symptoms. However, the underlying mechanism of stress-induced gastrointestinal dysfunction is not known. The enteric nervous system plays a major role in the regulation of gastrointestinal function and the proposed study is aimed at understanding the role of a membrane receptor called LPA1 in the enteric nervous system in stress- induced intestinal dysfunction.

PI_NAMEs: YUN, CHANGHYON CHRIS (contact)

PROJECT_TERMS: absorption;Adverse effects;Affect;Afghanistan;Anxiety;anxious;Apical;Bacteria;Bacterial Infections;Biological Process;Cell Line;Cell model;Cell Proliferation;Cell Survival;Cells;Central Nervous System;Chronic;Citrobacter rodentium;Colitis;comorbidity;Complex;Conflict (Psychology);Constipation;Data;Defect;depressive symptoms;Development;Diarrhea;Disease;Enteral;enteric infection;Enteric Nervous System;Environment;environmental stressor;Epithelial Cells;epithelial repair;Epithelium;established cell line;Event;Exhibits;Face;Functional disorder;G-Protein-Coupled Receptors;gastrointestinal;Gastrointestinal Diseases;gastrointestinal epithelium;gastrointestinal function;Gastrointestinal Motility;gastrointestinal symptom;Gastrointestinal tract structure;glial cell-line derived neurotrophic factor;Gulf War veteran;gut inflammation;Health Services;Home;Homeostasis;Hypersensitivity;improved;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;intestinal barrier;Intestinal Diseases;intestinal epithelium;Intestinal Motility;Intestinal permeability;Intestines;Ions;Iraq;Irritable Bowel Syndrome;Link;Liquid substance;lysophosphatidic acid;Mediating;Mediator;Membrane;Mental Depression;microorganism;Military Personnel;military veteran;monolayer;Motility;motility disorder;mouse model;Mucous Membrane;Mus;Nerve Fibers;Nervous System Physiology;Neuroglia;Neurons;novel;pain perception;Pathogenesis;Pathway interactions;Patients;Permeability;Phenotype;Phospholipids;Play;Post-Traumatic Stress Disorders;Predisposition;Process;Proliferating;receptor;Receptor Signaling;Regulation;Reporting;Risk;Role;service member;Signal Transduction;Sodium;Stress;stress symptom;Testing;Veterans;vzg-1 Receptor;War;Work;wound healing

PROJECT_TITLE: Regulation of intestinal epithelial barrier and motility by the LPA1 receptor in the enteric nervous system

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 GAST-L (01)]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Microbiome;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Hypertension is the most prevalent risk for cardiovascular disease, diabetes, obesity, chronic kidney disease and obstructive sleep apnea and patients with “treatment-resistant hypertension,” defined by inability to achieve blood pressure control despite use of ≥3 antihypertensive drugs, are at particularly high risk of these adverse outcomes. We propose that treatment-resistant hypertension stems, at least in part, from gut dysbiosis and associated gut inflammation, neuroinflammation promoting autonomic nervous system activation, or both; and, that minocycline (an antibiotic with anti-inflammatory properties) can ameliorate these disorders. We aim to conduct a randomized clinical trial of minocycline versus placebo, to determine the extent to which these mechanisms contribute to the blood pressure-lowering effect of minocycline, and whether these mechanisms may differ in Black and White Americans.

PI_NAMEs: PEPINE, CARL J;SMITH, STEVEN MICHAEL (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Activities of Daily Living;Address;adverse outcome;Affect;African American population;Aldosterone;American;Animals;Anti-Hypertensive Agents;Anti-Inflammatory Agents;Antibiotics;Antiinflammatory Effect;Attenuated;attenuation;Autonomic nervous system;Bacteria;Black American;Blood Pressure;blood pressure control;blood pressure reduction;Blood specimen;blood-brain barrier crossing;Brain;Brain imaging;Butyrates;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;caucasian American;Cells;Cessation of life;Chronic Kidney Failure;Data;design;Development;Diabetes Mellitus;Disease;Disparity;Diuretics;Enrollment;Enzyme-Linked Immunosorbent Assay;Equilibrium;Exhibits;FABP2 gene;Flow Cytometry;Fostering;Functional disorder;Funding;gastrointestinal epithelium;Genes;gut dysbiosis;gut inflammation;gut microbiota;Health Expenditures;health related quality of life;Heart failure;heart rate variability;Heterogeneity;high risk;high risk population;host microbiota;Hour;Human;Hypertension;hypertension control;Immune;immune function;Immunoglobulin A;Impairment;improved;Inbred SHR Rats;Incidence;Inflammation;Inflammatory;Inflammatory Response;Investigation;Kidney Diseases;LCN2 gene;Leaky Gut;Life Style;Magnetic Resonance Imaging;Mediating;Medical;metagenomic sequencing;microbiota;microbiota composition;Microglia;Minocycline;Modeling;modifiable risk;mouse model;Nerve;neurogenic hypertension;neuroinflammation;novel;Obesity;Obstructive Sleep Apnea;Oral;Outcome;Pathway interactions;patient subsets;Patients;peripheral blood;pharmacologic;Pharmacotherapy;pilot trial;Placebos;Plasma Cells;Positron-Emission Tomography;PPAR gamma;Prevalence;prevent;Procedures;Property;racial disparity;randomized, clinical trials;remediation;renal artery;Resistant Hypertension;response;risk of major adverse events;Role;stem;Stroke;Sympathectomy;Testing;Therapeutic;Therapy trial;treatment disparity;zonulin

PROJECT_TITLE: Antihypertensive Mechanisms of Minocycline in Resistant Hypertension: Role of the gut microbiota-brain-immune axis

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ORG_CITY: NASHVILLE

ORG_STATE: TN

PHR: Clostridioides difficile is the leading cause of nosocomial diarrhea in the United States and an important source of morbidity and mortality among U.S. Military Veterans. C. difficile infection (CDI) can result in a spectrum of diseases that range from mild diarrhea to pseudomembranous colitis and can include life- threatening complications such as perforation of the colon, toxic megacolon, and sepsis. CDI pathology is associated with the action of one or more toxins: toxin A (TcdA), toxin B (TcdB), and the C. difficile transferase toxin (CDT). While TcdA and TcdB are considered the primary drivers of symptoms, multiple studies suggest that CDT increases the severity of CDI. The increasing prevalence of CDT containing clinical isolates and the potential for developing CDT as an effective vaccine antigen necessitate a deeper understanding of how CDT functions.

PI_NAMEs: LACY, DANA BORDEN (contact)

PROJECT_TERMS: Actins;Address;Adherence;ADP Ribose Transferases;ADP ribosylation;Affect;Anaerobic Bacteria;Antibiotic Therapy;Antibiotics;Binding;Biological Assay;Caring;cell type;Cells;Clinical;Clostridium;Clostridium difficile;Colon;Complex;cytolethal distending toxin;Cytoskeleton;Cytosol;Data;Diarrhea;Disease;Endocytosis;endosome membrane;Endosomes;Enzyme-Linked Immunosorbent Assay;eosinophil;Epithelium;Family;Feces;Foundations;G Actin;Gastrointestinal tract structure;Generations;Genes;Goals;host microbiome;Human;Image;Impairment;in vivo;Incidence;Infection;Inflammasome;Intestines;Intoxication;Knowledge;Left;Length;Life;Lipolysis;Lipoprotein Receptor;Literature;Mediating;Microtubules;military veteran;Monitor;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Mus;Nosocomial Infections;Pathogenesis;Pathology;Perforation;Prevalence;Production;Progress Reports;Proteins;Pseudomembranous Colitis;Publishing;Reagent;Recurrence;Reproduction spores;response;Role;Sepsis;Severities;Source;Structure;Symptoms;T-Cell Activation;Time;tool;Toxic Megacolon;Toxin;Transferase;United States;Vaccine Antigen;vaccine development;VDAC1 gene;Veterans;Veterans Health Administration;Virulence Factors;Visualization

PROJECT_TITLE: The role of toxins in Clostridioides difficile infection pathogenesis.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 INFB-K (01)]


NIH_SPENDING_CATS: Arthritis;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Mechanisms by which cell-surface attachment factors function in cell binding, tropism, and virulence of arthropod-borne viruses are poorly understood. This project will elucidate in molecular detail how chikungunya virus (CHIKV) engages host glycosaminoglycans as attachment factors and define the contribution of specific glycan binding to CHIKV infectivity, dissemination, tropism, and disease outcomes. These studies will enhance an understanding of the structure-function relationships of CHIKV-glycosaminoglycan binding and may foster development of improved therapeutics targeting virus-glycosaminoglycan interactions to block infection.

PI_NAMEs: SILVA, LAURIE A. (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: 2019-nCoV;Acute;Acute Disease;Adhesions;Affect;Affinity;Alanine;Alpha Virus;Anti-viral Agents;Arthritis;Arthritogenic;arthropod-borne;attenuation;Binding;Binding Sites;Biochemical;biophysical properties;Biophysics;Carbohydrates;Cell Line;Cell surface;cell type;Cell-Matrix Junction;Cells;Cellular Tropism;Chikungunya virus;Chronic;Clinical;Complex;conditional knockout;Cryoelectron Microscopy;Data;Defect;defined contribution;Dependence;Development;Disease;disease model;Disease Outcome;Economics;Endothelial Cells;Engineering;Enzymes;experimental study;Fever;Flavivirus;Fostering;Genes;Genetic;global health;Glycoproteins;Glycosaminoglycans;Heparitin Sulfate;Herpesviridae;HIV;Human;human pathogen;Immune response;improved;In Vitro;Infection;Inflammatory;insight;Kinetics;Knockout Mice;Knowledge;Length;Libraries;Licensing;Long term disability;loss of function;loss of function mutation;Mammalian Cell;Mediating;Modification;Molecular;mosquito-borne;mouse model;Mus;Muscle Cells;Musculoskeletal;Mutagenesis;mutant;Mutation;Pain;Pathogenesis;pathogenic virus;Pathogenicity;Persons;Polyarthritides;Polysaccharides;Proteins;rational design;receptor;receptor binding;Research;Resolution;Role;social;Specificity;Structure;Structure-Activity Relationship;Sulfate;Surface Plasmon Resonance;Symptoms;Techniques;Testing;Therapeutic Agents;therapeutic target;tissue tropism;Tissues;transmission process;Tropism;Vaccines;Viral;Viral Pathogenesis;Virion;Virulence;Virus;Virus Diseases;virus host interaction;Virus Replication;Work

PROJECT_TITLE: Molecular mechanisms governing chikungunya virus binding, tropism, and pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 VDT-Q (01)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Patient Safety;Prevention

ORG_CITY: DURHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Treatment, management, and prevention of cancer involves a series of decisions over time based on accruing patient information. This research will develop methods for the design and analysis of specialized clinical trials that are ideally suited to discovery and evaluation of overall strategies for cancer treatment, management, and prevention over an entire sequence of decisions, with the goal of identifying strategies that lead to the greatest expected patient beneﬁt.

PI_NAMEs: LABER, ERIC BENJAMIN (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Acceleration;Address;adverse outcome;anti-cancer research;Anxiety;Behavior Therapy;cancer clinical trial;cancer prevention;cancer therapy;Characteristics;Clinic;Clinical Trials;Clinical Trials Design;Combined Modality Therapy;Complex;Computer software;Data;Decision Making;design;Disease;Evaluation;Event;evidence base;Futility;Future;Generations;Goals;handheld mobile device;Health;improved outcome;individual patient;ineffective therapies;innovation;interest;Intervention;Joints;Knowledge;Malignant Breast Neoplasm;Malignant Neoplasms;Methodology;Methods;mHealth;mhealth interventions;Modality;Monitor;multimodality;next generation;novel;optimal treatments;Outcome;Pain;Participant;participant enrollment;patient population;Patient-Focused Outcomes;Patients;Phase;Play;Population;preservation;Prevention;Probability;Process;psychologic;Quality of life;Randomized;randomized trial;Research;Research Design;Research Priority;response;Role;screening;secondary analysis;Selection for Treatments;Sequential Multiple Assignment Randomized Trial;Sequential Treatment;Series;side effect;Software Engineering;standard of care;success;Symptoms;Therapeutic;Therapeutic Agents;Therapeutic Intervention;therapy adverse effect;therapy design;Time;treatment optimization;treatment strategy;trial design;Update;uptake;Work

PROJECT_TITLE: Next-generation SMARTs for Discovery and Evaluation of Sequential Cancer Therapeutic Strategies

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: NARRATIVE As the bladder fills, it must remain compliant enough to expand and store urine but stiff enough to expel urine when muscles contract to void. Surprisingly, the way in which we sense the need to void when the bladder is full is still poorly understood. The goal of this project is to understand how the structure of the bladder wall interacts with sensory nerves to create the feeling of fullness, which is imperative to understanding the pathology of bladder dysfunction.

PI_NAMEs: ROCCABIANCA, SARA ;TYKOCKI, NATHAN ROGER (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: 3-Dimensional;4D Imaging;afferent nerve;Behavior;biomechanical model;Biomechanics;Bladder;Bladder Dysfunction;Bladder Tissue;Brain;Central Nervous System;Characteristics;clinical application;Connective Tissue;Conscious;Contracts;Elastic Tissue;Elasticity;Elements;Engineering;Esthesia;Event;experimental study;Extracellular Matrix;Feeling;Fibroblasts;Genetic;Giant Cells;Goals;Histology;Image;Imaging Device;in vivo;Individual;innovation;intravesical;Learning;Location;Measurement;Measures;mechanical properties;Mechanics;Modeling;Motion;mouse model;Mus;Muscle;Muscle Contraction;Nerve;neurophysiology;novel;optogenetics;Overactive Bladder;Paper;Pathology;Perception;Physiology;pressure;Property;Proteins;recruit;Sensory;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;Source;Stress;Stretching;Structure;System;Techniques;Testing;tool;Transducers;two photon microscopy;Urine;Urothelial Cell;viscoelasticity;Viscosity;Work

PROJECT_TITLE: Bladder Wall Stiffness Drives Sensation of Fullness

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE Tuberculosis (TB) and non-tuberculous mycobacterial diseases remain a global health emergency despite being curable and preventable. Current treatments are long, toxic and progressively ineffective with rising drug resistance and call for a specific focus on unexploited targets to develop new antibiotics. Lpd is a genetically validated target in Mtb and this application aims to explore Lpd tight binding inhibitors to identify features that can predict and improve their in vivo efficacy.

PI_NAMEs: BRYK, RUSLANA  (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: acute infection;Acyltransferase;Affinity;analog;Anti-Bacterial Agents;Antibiotics;Antioxidants;axenic culture;Bacteria;Bacterial Infections;Binding;Binding Sites;Biological Assay;Biology;Biophysics;Bone Marrow;Cause of Death;Cells;Cessation of life;Chemicals;chronic infection;Clinical;Collaborations;Complex;COVID-19 pandemic effects;Cryoelectron Microscopy;Data Correlations;data modeling;Dedications;design;Development;dihydrolipoamide dehydrogenase;Disease;Disease Management;Dose;Drug resistance;Enzyme Inhibitor Drugs;Enzyme Kinetics;Enzymes;FDA approved;Gel Chromatography;Genus Mycobacterium;global health emergency;Growth;Immunocompetent;Immunocompromised Host;improved;In Vitro;in vivo;Individual;Infection;inhibitor;Institution;Keto Acids;ketoglutarate dehydrogenase;Knowledge;lead candidate;Libraries;lipoamide;Macrophage;Measures;Metabolic;Metabolism;metabolomics;Molecular Structure;mortality;mouse model;Multienzyme Complexes;Mus;mycobacterial;Mycobacterium abscessus;Mycobacterium avium;Mycobacterium tuberculosis;Mycobacterium tuberculosis complex;Nitroimidazoles;non-compliance;non-tuberculosis mycobacteria;non-tuberculous mycobacterial infection;novel;Orthologous Gene;Oxidoreductase;pathogen;Pathogenicity;Peroxidases;peroxynitrite reductase;Pharmaceutical Preparations;Post-Translational Protein Processing;protein complex;Proteins;pyruvate dehydrogenase;Pyruvate Dehydrogenase Complex;Recombinants;Regimen;Research Institute;residence;Resistance;Resolution;scaffold;Services;Structure;Structure-Activity Relationship;Sulfonamides;Testing;Therapeutic;Therapeutic Index;Time;tool;Toxic effect;Treatment Protocols;Tuberculosis;tuberculosis drugs

PROJECT_TITLE: Studies of lipoamide dehydrogenase tight binding inhibition in tuberculous and non-tuberculous mycobacteria

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Mental Health;Neurosciences

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Glial cells such as astrocytes and microglia are crucial for influencing neural circuit function including those that, like the amygdala, underlie responses to learned fear. However, upon repeated stress exposure, pro- inflammatory signaling is elevated in the amygdala, which dysregulates faithful assessments of environmental threats by glial cells and neurons. The goal of this proposal is to define how a candidate anti-inflammatory pathway driven by AREG+ microglia and EGFR+ astrocytes limits fear responses by suppressing the activation of the ETV1 transcription factor in astrocytes in the basolateral amygdala, which may uncover new therapeutic targets for neurologic disorders where aberrant activation of the amygdala is a hallmark.

PI_NAMEs: WHEELER, MICHAEL ALEX (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Acute;acute stress;Address;Amphiregulin;Amygdaloid structure;Anti-Inflammatory Agents;Anxiety;Area;Astrocytes;Behavior;Binding;Brain;Cell Communication;Cell Nucleus;cell type;Cells;Central Nervous System;Chromatin;Chronic;Chronic stress;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;conditioned fear;Coupled;CRISPR library;CRISPR screen;Cues;Data;Encapsulated;Epidermal Growth Factor Receptor;Epigenetic Process;ETV1 gene;Family;Family member;Feedback;Fibrinogen;Fire - disasters;Fluorescence;Fright;Genes;Genetic;Genetic Screening;Genetic Transcription;genome-wide;Genomics;Goals;Immune response;in vivo;Inflammation;Inflammatory;Knowledge;Learning;Link;Mediator;Mental disorders;Methods;Microfluidics;Microglia;Molecular;multiple omics;Mus;Nervous System Disorder;neural;neural circuit;Neuroglia;Neurologic;Neurons;new therapeutic target;NF-kappa B;novel;Pathway interactions;Physiological;programs;receptor;Recurrence;Reporter;response;Role;Sensory Process;Shapes;Signal Induction;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Sorting;Stimulus;Stress;Testing;Therapeutic;tool;transcription factor;Transgenic Organisms

PROJECT_TITLE: Control of ETV1 transcriptional networks in amygdalar astrocytes

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Eczema / Atopic Dermatitis;Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The nervous system interacts with the immune system and plays a crucial role in atopic dermatitis and other allergic skin diseases. The proposed research will investigate physiologic signals that induce itch and inflammation by acting on cutaneous nerves. The goal of this research is to understand how these signals mediate interactions between the nervous and immune systems and assess their potential as new drug targets for the treatment of itch and inflammation.

PI_NAMEs: LERNER, ETHAN A (contact)

PROJECT_TERMS: Abdomen;Ablation;afferent nerve;Afferent Neurons;Allergens;Allergic;Allergic Contact Dermatitis;Allergic inflammation;antagonist;Arthritis;Asthma;Atopic Dermatitis;Attenuated;Automobile Driving;behavior measurement;Behavioral Model;Biology;Cells;Chemicals;Clinic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Contact Dermatitis;Cutaneous;Data;Denervation;density;deprivation;Dermatitis;Dimensions;Disease;Engineering;environmental allergen;Epithelium;Esthesia;Family;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genes;Genetic;Goals;high resolution imaging;Human;human disease;Immune;Immune system;Immunology;In Situ Hybridization;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;insertion/deletion mutation;Intestines;Investigation;Knowledge;Ligands;Link;mast cell;Mediating;Mediator;member;Modeling;Molecular;Monitor;mouse model;Mus;Mutation;Nature;Nerve;Nerve Endings;Nerve Fibers;Nerve Growth Factor Receptors;Nervous System;neural;Neurogenic Inflammation;Neuroimmune;Neurons;Neuropeptides;Neurosciences;neurotransmitter release;neurotrophic factor;new therapeutic target;novel;Pain;pathobiont;Penetration;Peptide Hydrolases;Peripheral Nerves;pharmacologic;Physiological;Play;Process;Pruritus;Psoriasis;Publishing;receptor;Recurrence;Reporter;Research;Research Project Grants;response;RNA;Rodent Model;Role;Severities;Shapes;Signal Induction;Signal Transduction;Site;Skin;skin barrier;skin disorder;Skin Tissue;Spinal Ganglia;Staphylococcus aureus;Structure;Substance P;Surface;Symptoms;synergism;TACR1 gene;targeted treatment;Testing;Time;Tissues;transcriptomic profiling;transcriptomics;Translating;treatment strategy;tumor-immune system interactions;Visualization;Wheezing

PROJECT_TITLE: Neuronal MRGPR signaling in itch and allergic skin inflammation

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Violence Research;Youth Violence

ORG_CITY: CHICAGO

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Young Asian Americans report an alarming rate of mental health problems—a major public health concern— due to acculturative and racial minority stresses, alongside the unprecedented surge in anti-Asian racism and bigotry provoked by the COVID-19 pandemic. This study will investigate how the intersections of culturally unique family process, racial experience and acculturative pressure impact young Asian Americans and their adjustments during transition from adolescence to young adulthood and pre and post COVID-19 pandemic. Results from the study will be used to develop comprehensive, evidence-based interventions to assist youths and young adults building the resilience to withstand adversities of acculturative and minority stress.

PI_NAMEs: CHOI, YOONSUN  (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: 19 year old;Acculturation;Adolescence;Adolescent;affection;age group;American;anti-Asian;Anxiety;Area;Asian;Asian Americans;Biological;Biological Markers;C-reactive protein;career;Cause of Death;Chicago;Child;Chronic;Chronic stress;Complex;Conflict (Psychology);COVID-19 pandemic;cultural competence;Data;Data Set;Databases;Development;Diagnosis;Discrimination;Distress;early adolescence;Education;Employment;Environment;ethnic identity;Ethnic Origin;Etiology;evidence base;Evidence based intervention;expectation;experience;Family;Family Process;Feeling suicidal;Filipino American;Foundations;Funding;Gender;hate crimes;Health;health disparity;Home;Hostility;Hydrocortisone;Immigrant family;improved;Individual;intergenerational;Intervention;Korean American;Longitudinal Studies;Major Depressive Disorder;Major Mental Illness;Marriage;Measures;Mental Depression;Mental Health;metropolitan;Midwestern United States;Minority;Minority Groups;Minority Status;minority stress;minority stressor;National Institute of Child Health and Human Development;Occupations;Onset of illness;Outcome;Outcome Measure;pandemic disease;Parents;Participant;Pattern;perceived discrimination;perceived stress;Personal Satisfaction;Persons;physical conditioning;Physiological;Politics;Positioning Attribute;post-COVID-19;pressure;promote resilience;Psyche structure;psychologic;psychosocial stressors;Public Health;public health relevance;Race;racial discrimination;racial minority;racial population;racism;Reporting;response;Risk Behaviors;Sampling;Secure;Sleep;Socialization;Stereotyping;Stress;stressor;suicidal;Suicide;Surveys;Testing;trend;Violence;young adult;Youth

PROJECT_TITLE: Racial discrimination, Intergenerational Cultural Conflict and Asian American Mental Health

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


FUNDING_MECHANISM: OTHERS

ORG_CITY: OMAHA

ORG_NAME: OMAHA VA  MEDICAL CENTER

ORG_STATE: NE

PHR: This proposal addresses a significant healthcare issue that affects Veterans, military personnel, and their families disproportionately to the general population. Here, work from Dr. Dhawan’s research program is focused on the investigation of mechanism/s and therapeutic targets in colon cancer progression and metastasis. Colon Cancer metastasis represent a major clinical challenge in the VA, since there are no current, effective therapeutic interventions, and metastatic colorectal cancer can result in therapy resistance and finally death. Work from her lab aims to provide a better understanding of mechanism/s of colon cancer progression and to increase opportunities for the development of novel treatment paradigms.

PI_NAMEs: DHAWAN, PUNITA  (contact)

PROJECT_TERMS: Address;Affect;analog;anti-cancer research;antibody conjugate;Area;Award;Basic Science;Book Chapters;Cancer Biology;cancer cell;career;Cell Culture Techniques;Cell Cycle Proteins;Cell Line;Cessation of life;claudin-1 protein;Clinical;clinical efficacy;clinical investigation;Clinical Research;Collaborations;Colon;colon cancer metastasis;colon cancer progression;colon carcinogenesis;Colon Carcinoma;colorectal cancer progression;conventional therapy;detection method;Development;Diagnosis;Disease;Doctor of Philosophy;Early Diagnosis;efficacy evaluation;Environment;Epithelium;Evaluation;Experimental Designs;Family;Family member;Female;Financial Hardship;fluorophore;Funding;Gastroenterology;General Population;Generations;genetically modified cells;Grant;Grant Review;Healthcare;Height;Homeostasis;imaging probe;Immunology;improved;In Vitro;in vivo;Incidence;inhibitor;International;intestinal homeostasis;Investigation;Investments;Journals;Laboratories;Laboratory Study;Leadership;male;Malignant Neoplasms;Manuscripts;Mediating;Medical;Medical center;Mentors;metastatic colorectal;Military Personnel;Mission;Modeling;Molecular;Monitor;mortality;mouse model;Mucous Membrane;multidisciplinary;Mus;Nature;Neoplasm Metastasis;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;Organoids;Outcome;Pathology;Patients;Peer Review;Physiology;Polyps;Population;population health;pre-clinical assessment;preclinical safety;preclinical study;Process;programs;Protein Family;Proteins;Publications;Publishing;Quality of life;Reagent;Regulation;Research;Research Peer Review;Research Personnel;Resistance;Role;Scientist;Seminal;small molecule inhibitor;Solid;success;symposium;targeted imaging;targeted treatment;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic target;therapeutically effective;Tight Junctions;Training;Treatment Efficacy;treatment response;Tumor Suppressor Proteins;tumor xenograft;tumorigenesis;undergraduate student;United States;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;Veterans;Work;World Health

PROJECT_TITLE: BLRD Research Career Scientist Award Application

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 RCSR-N (01)]


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

ORG_CITY: CORAL GABLES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative An expansive investigation will be performed in vivo and in vitro to determine factors (protein and RNA) and their mode of operation in coordinating specific chromatin-chromatin interactions that insulate repressed from active chromatin domains. This differentiation-related process is instrumental to acquiring the specific gene expression patterns that reflect disparate cell types.

PI_NAMEs: MAZZONI, ESTEBAN ORLANDO;REINBERG, DANNY  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: 3-Dimensional;Anterior;Binding;Binding Sites;Biological;Boundary Elements;CCCTC-binding factor;Cell Differentiation process;cell type;Cells;Cervical;Chromatin;Chromatin Loop;Chromosome Structures;Clip;cohesin;Collaborations;Complement;Data;Development;Disparate;DNA;DNA Binding;Elements;Embryonic Development;Epigenetic Process;Exhibits;Fingers;Fostering;Foundations;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene repression;Gene Structure;Genes;genetic manipulation;Genetic Transcription;Genome;Genomics;Homeobox Genes;In Vitro;in vivo;Individual;interest;Invaded;Investigation;knock-down;Knock-out;Knowledge;Location;Maintenance;Mammalian Cell;Mediating;Modeling;Molecular;motor control;Motor Neurons;Mus;mutant;Mutation;Neuronal Differentiation;operation;Organism;Pattern;Positioning Attribute;Process;Productivity;protein function;Proteins;Publishing;Regulation;Reporting;Repression;RNA;RNA Binding;RNA Recognition Motif;Role;screening;Site;Specificity;Spinal Cord;Structure;Technology;Zinc Fingers

PROJECT_TITLE: Understanding CTCF Boundaries Controlling Hox Gene Expression

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Gene Therapy;Genetics;Immunotherapy;Infectious Diseases;Lung;Nanotechnology;Pneumonia;Pneumonia and Influenza

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE This project aims to develop a targeting strategy involving macrophage-targeting peptide ligands for targeted delivery of nanoplatforms that carry RNA therapeutics. Deploying existing or newly discovered peptides and deploying design rules from three broad classes of nanoparticles (lipid-based, tandem peptide-based, and mesoporous silicon-based) and it will identify an optimal nanoplatform to treat in vivo carbapenem-resistant Klebsiella pneumoniae (CRKP), Aspergillus fumigatus, and influenza A pneumonia.

PI_NAMEs: SAILOR, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Address;Affinity Chromatography;Anti-viral Agents;Antibiotics;Aspergillus fumigatus;Bacteria;Bacterial Infections;Bacterial Pneumonia;bacterial resistance;Benchmarking;Biological;Bronchoalveolar Lavage Fluid;carbapenem resistance;Cells;Cessation of life;combat;cytotoxicity;design;Drug Kinetics;Drug or chemical Tissue Distribution;effective therapy;efficacy evaluation;Elements;fighting;fungal pneumonia;fungus;Genes;Goals;Hepatic;Histopathology;Homing;Immune response;Immunotherapy;improved;In Vitro;in vivo;Industry;Infection;Inflammatory;Inflammatory Response;Influenza;influenza A pneumonia;Influenza A virus;Innate Immune System;Intravenous;intravenous administration;Kidney;Klebsiella pneumoniae;knock-down;Lead;lead candidate;Libraries;Life;Ligands;lipid nanoparticle;Lipids;Lung;Lung infections;Macrophage;Mass Spectrum Analysis;Mediating;Metabolic;Modality;Modeling;mouse model;Mus;nanomedicine;nanoparticle;nanosystems;nanotechnology platform;nanotherapeutic;nanotoxicity;Natural Immunity;Nebulizer;novel therapeutics;nucleic acid delivery;nucleic acid-based therapeutics;Organ;pathogen;pathogenic bacteria;pathogenic fungus;pathogenic virus;Pathogenicity;Peptides;Performance;Phage Display;Plasma;Play;Pneumonia;pneumonia model;pneumonia treatment;Porosity;preservation;prevent;programs;receptor;Recovery;resistant Klebsiella pneumoniae;response;Ribonucleases;RNA;RNA delivery;RNA Interference Therapy;Role;Route;Sampling;screening;side effect;Silicon;siRNA delivery;Surface;System;targeted delivery;Therapeutic;therapeutic RNA;Tissues;tool;Treatment Efficacy;United States National Institutes of Health;Update;uptake;Vaccines;Viral;Viral Pneumonia;Virus

PROJECT_TITLE: Macrophage-targeting Nanoplatforms as Immunotherapy against Pulmonary Infections

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Multiple system atrophy (MSA) is a rare, progressive, and fatal neurodegenerative disease characterized by selective accumulation of α-synuclein in glial cytoplasmic inclusions (GCIs) within oligodendrocytes. We propose to use single nucleus RNA sequencing to understand how gene expression is perturbed in multiple cell types in the brain of MSA patients compared to healthy individuals. Uncovering these changes will allow us to understand the types of dysfunction that lead to neurodegeneration and identify their potential causes as possible therapeutic targets.

PI_NAMEs: KANG, UN JUNG (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: Affect;Age;alpha synuclein;Astrocytes;Atlases;Autopsy;Brain;Brain region;brain tissue;Cell Nucleus;Cell Physiology;cell type;Cells;Cerebellar Diseases;Cerebellum;cerebral atrophy;Classification;Clinical;Complex;Corpus striatum structure;Cytoplasmic Inclusion;Data;Data Set;differential expression;Dysautonomias;Event;Exhibits;Experimental Models;Fluorescent in Situ Hybridization;Functional disorder;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Human;human tissue;Immunohistochemistry;In Situ Hybridization;Individual;Informatics;insight;Mediating;Messenger RNA;Microglia;Modeling;Molecular;Molecular Profiling;Morphology;Multiple System Atrophy;Myelin;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neurons;nonhuman primate;Oligodendroglia;Olivopontocerebellar Atrophies;overexpression;Parkinsonian Disorders;Pathologic;Pathologic Processes;Pathology;Pathway interactions;Patients;Phenotype;Physiology;putamen;response;Secondary to;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;Stress;Striatonigral Degeneration;synuclein;System;Techniques;Testing;therapeutic target;Tissues;transcriptome;transcriptomics;Up-Regulation

PROJECT_TITLE: Single Cell Transcriptomic Profiling of Multiple System Atrophy Brain

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Project Narrative Electrocardiographic (ECG) monitoring, in the hospital setting remains unsatisfactory as evidenced by the well- documented alarm fatigue problem, which threatens patient safety. Evidenced-based solutions, like the ventricular tachycardia algorithms we will create in this study, can only deliver benefits if transdisciplinary teams including nurses, physicians, engineers, data scientists, and software developers come together to create innovative solutions. Given the complexity of this substantial problem, it is vital that potential solutions have broad application in a variety of hospital settings and patient populations where ECG monitoring is utilized (i.e., ICU, step-down/telemetry).

PI_NAMEs: PELTER, MICHELE M. (contact)

PROGRAM_OFFICER_NAME: HSU, LI-YUEH

PROJECT_TERMS: Address;Adult;Algorithm Design;Algorithms;analog;Arrhythmia;Artificial Intelligence;Atrial Fibrillation;Belief;Blood Pressure;Bundle-Branch Block;Cardioscopes;Care given by nurses;Clinical;Clinical Research;clinically relevant;cohort;Collaborations;Computer software;convolutional neural network;Data;Data Science;Data Scientist;Data Set;Databases;Decision Making;design;Early Diagnosis;Education;Electric Countershock;Electrocardiogram;Electrodes;Electrolytes;Engineering;Evaluation;Event;evidence base;Exhibits;explainable artificial intelligence;Fatigue;Goals;Heart;Heart Arrest;heart rhythm;hospital care;Hospitalization;Hospitals;Hour;Human;improved;innovation;Intensive Care Units;Intervention;Lead;Life;Liquid substance;Machine Learning;Manuals;Manufacturer;Mechanical ventilation;Methods;Modernization;Monitor;Morbidity - disease rate;mortality;Nervous System Physiology;Noise;novel;Nurses;Outcome;Pacemakers;patient population;patient safety;Patients;performance tests;Persons;Physicians;predictive modeling;Predictive Value;Process;prospective;Research;Scientist;signal processing;Signal Transduction;Sinus Tachycardia;Skin;structural heart disease;Survival Rate;System;Technology;Telemetry;Testing;United States;United States Food and Drug Administration;Ventricular;Ventricular Tachycardia;Work

PROJECT_TITLE: Evaluation of a novel ECG algorithm to identify and predict ventricular tachycardia in ICU and non-ICU patients with in-hospital cardiac arrest

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Narrative  Widespread genomic mosaicism in somatic cells of phenotypically normal individuals is now well established. We recently discovered a phenomenon of frequent hypermutability in adult brains (at least 3% of individuals over 40 years old). The origin(s) of the hypermutability is unknown and the goal of the proposed study is to firmly establish the origin(s). We have three hypotheses explaining hypermutability. Proving the hypothesized origins of hypermutability will be a fundamental contribution to understanding brain development and aging in humans and will lay the foundation for future studies of the underlying mechanisms.

PI_NAMEs: ABYZOV, ALEXEJ  (contact)

PROJECT_TERMS: Adult;Age;age related neurodegeneration;age-related disease;Aging;Alzheimer's Disease;autism spectrum disorder;Automobile Driving;Blood;Blood - brain barrier anatomy;Blood Cells;Brain;brain based;Brain region;Cardiovascular Diseases;Cell division;Cell Lineage;Cell Nucleus;cell type;Cells;Clonal Expansion;Confidence Intervals;cost efficient;Data;deep sequencing;Development;Diagnosis;Disease;disease phenotype;DNA amplification;DNMT3a;Foundations;Frequencies;Future;Genes;genetic variant;Genome;genome sequencing;Genomics;Genotype;Germ Lines;Gilles de la Tourette syndrome;gliogenesis;Goals;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Human;Individual;Infiltration;Inherited;Judgment;Malignant neoplasm of brain;Malignant Neoplasms;mortality;mosaic variant;Mosaicism;Mutagenesis;Mutation;neural;Neurodegenerative Disorders;Neurons;neuropsychiatric disorder;Phenotype;Population;Predisposition;Role;Sampling;Schizophrenia;single nucleus RNA-sequencing;Somatic Cell;targeted sequencing;transcriptome;transmission process;Variant;whole genome

PROJECT_TITLE: Uncovering the origin of hypermutability in adult brains

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: STONY BROOK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative Emotional and cognitive impairments are prevalent in neuropsychiatric disorders such as post-traumatic stress disorder (PTSD). In particular, PTSD is characterized by a lasting inability to discriminate innocuous stimuli from ones that predict danger, and maladaptive coping strategies. Herein we propose studies using intersectional chemogenetics in mice in order to study brain pathways important for translational regulation of learned threat and to delineate molecular candidates for potential therapeutic intervention in PTSD.

PI_NAMEs: SHRESTHA, PRERANA  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Adult;Amygdaloid structure;Axon;Behavior;Binding;Biological;Brain;Brain Diseases;brain pathway;Brain region;Cell Nucleus;cell type;Cells;Characteristics;Cognition;comparison control;Complex;conditioning;Coping Skills;Corpus striatum structure;Cues;Development;Diagnosis;Double-Stranded RNA;EIF-2alpha;Emotional;Emotional disorder;Eukaryotic Initiation Factor-2;Eukaryotic Initiation Factor-4E;Event;FRAP1 gene;Freezing;Fright;Functional disorder;functional plasticity;Future;Gene Transfer;Genetic;genetic approach;Glutamates;Goals;Image;Impaired cognition;inducible gene expression;insight;knock-down;Knowledge;Learning;long term memory;Maintenance;Medial;Mediating;Memory;memory consolidation;memory process;Molecular;Molecular Profiling;mouse genetics;mouse model;Mus;neural;neural circuit;Neural Pathways;Neurobiology;Neurons;neuropsychiatric disorder;Pathway interactions;permissiveness;pharmacologic;Pharmacology;Phosphorylation;Phosphotransferases;Physiological;Population;Post-Traumatic Stress Disorders;Prefrontal Cortex;PRKR gene;programs;Prosencephalon;Protein Biosynthesis;Protein Dephosphorylation;Protein Dynamics;Proteins;Proxy;recruit;Research;Resolution;Ribosomal Protein S6;Role;Sensory;Signal Pathway;Signal Transduction;spatiotemporal;Specificity;Stimulus;Surveys;Symptoms;targeted treatment;Testing;Tetanus Helper Peptide;Thalamic structure;Therapeutic Intervention;therapeutically effective;Time;tool;transgene expression;translating ribosome affinity purification and RNA-sequencing;Translation Process;Translational Regulation;Translations;translatome;traumatic event;United States;Vertebral column;Viral;Work

PROJECT_TITLE: Prefrontal pathway-specific modulation of protein synthesis in emotional memories

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurosciences

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Project Narrative The cerebellum is essential for motor coordination and learning. Disorders of cerebellar development are associated with neurological diseases such as ataxia, autism, and medulloblastoma. Therefore, elucidating the mechanism that regulates the generation and diversification of different kinds of neurons during cerebellar development will provide the foundation for understanding and eventual treatment of these diseases.

PI_NAMEs: CHIANG, CHIN  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Acetylation;Affect;Ataxia;autism spectrum disorder;Binding;Binding Sites;Brain;Cell Cycle;Cell Cycle Inhibition;Cell Cycle Progression;Cell Lineage;Cell Proliferation;cell type;Cells;Cerebellar Diseases;Cerebellum;Chemicals;cognitive task;Complex;Congenital cerebellar hypoplasia;Data;Development;Disease;Embryo;Enhancers;Epigenetic Process;Feedback;Foundations;Gene Expression;Generations;Genes;genetic corepressor;Genetic Transcription;Goals;granule cell;Histone Deacetylase;Human;Injury;insulinoma associated 1;Knowledge;Learning;Medulloblastoma;Methylation;Modeling;Modification;Motor;motor behavior;Natural regeneration;Nervous System Disorder;Neurons;novel;Nucleic Acid Regulatory Sequences;Outcome;Population;Post-Translational Regulation;postmitotic;postnatal;Predisposition;Premature Infant;Process;Proliferating;protein degradation;Proteins;recruit;Repression;Repressor Proteins;Risk Factors;Role;sensory integration;Signal Transduction;stem cell fate;Testing;Time;transcription factor;Transcription Repressor;Zinc Fingers

PROJECT_TITLE: Regulatory mechanisms of cerebellar lineage development

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


PHR: PROJECT NARRATIVE Using single-cell RNA-sequencing, we have identified that type II cytokine IL-13 receptor is expressed on enteric, DRG and Nodose ganglion neurons that innervate gut and lungs. Genetic deletion of IL-13R on the enteric sensory neurons inhibits worm expulsion and inhibits the production of neuropeptides like NMU and CGRP. Here we propose to study how these cytokine receptors expressed on neurons regulate development of the type II inflammation.

PI_NAMEs: KUCHROO, VIJAY K. (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Adaptive Immune System;adaptive immunity;Address;Affect;Afferent Neurons;Allergens;Allergic Disease;Allergic inflammation;Allergic Reaction;Anthelmintics;antimicrobial;Asthma;atopy;Binding;Bronchial Spasm;Calcitonin Gene-Related Peptide;Cell Reprogramming;cell type;Cells;Chronic;conditional knockout;cytokine;Cytokine Receptors;Cytokine Signaling;Data;Data Set;Development;Diarrhea;Disease;disease model;Duodenum;Enteral;eosinophil;Epidemic;Epithelial Cells;Epithelium;Feedback;Fertility;Food Hypersensitivity;gastrointestinal;gastrointestinal epithelium;Genetic;Genetic Transcription;helminth infection;Helminths;Host Defense;Hypersensitivity;IL-13Ralpha1;Immune;Immune response;Immune system;Immunity;immunoregulation;Impairment;infancy;Infection;Inflammation;Inflammatory;innate immune function;Innate Immune System;Interleukin-13;interleukin-13 receptor;Interleukin-4;Interleukin-5;Interleukins;Intestines;Knockout Mice;Lung;Lymphoid Cell;Macrophage;Maps;Mediating;Mucous Membrane;Mus;Natural Immunity;Nematospiroides dubius;Neuroimmune;Neuromedin U;neuron development;neuronal survival;Neurons;Neuropeptide Gene;Neuropeptides;Nodose Ganglion;novel;Organ;Parasites;Peptides;Play;Population;Population Dynamics;Production;receptor;receptor expression;Receptor Signaling;recruit;response;Role;Signal Transduction;single-cell RNA sequencing;Stimulus;Surface;Surveys;Symptoms;System;therapeutic target;Tissues;Up-Regulation;Vomiting;Work

PROJECT_TITLE: Neuroimmune interactions regulate development of allergic inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-B (57)]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care;Suicide;Suicide Prevention

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative  Suicide in youth is rapidly growing to where it is the second leading cause of death across the United States. Use of accessible tools have shown the potential to boost primary care providers’ detection of suicide risk and confidence and knowledge around addressing it; however, effective ways to address clinic and provider barriers that impact the sustained implementation of a pathway to manage at-risk patients remain underexplored. The proposed study will assess the impact of our Facilitated Suicide Prevention program-- which provides implementation support to assist practices in integrating screening, assessment, data analysis and management protocols into routine care through longitudinal feedback and coaching--on clinic adoption of a suicide prevention pathway and youth suicidality.

PI_NAMEs: ANTHONY, BRUNO J (contact);PITTS, BRIAN H;STUDTS, CHRISTINA RUTH

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Address;Administrator;Adopted;Adoption;arm;behavioral health;Caring;Cause of Death;Cessation of life;Characteristics;Childhood;Clinic;Clinical;Clinical Pathways;clinical practice;Cluster randomized trial;Communities;Competence;contextual factors;Counseling;Data;Data Analyses;Data Collection;data management;design;Detection;Effectiveness;effectiveness outcome;effectiveness/implementation hybrid;effectiveness/implementation trial;Family;Family Practice;Feedback;Feeling suicidal;follow-up;Goals;gun violence;Health Personnel;high risk;implementation framework;implementation outcomes;implementation strategy;improved;Individual;Infrastructure;Intervention;Knowledge;Measures;Medical;Mental Health;Modeling;National Institute of Mental Health;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Perception;Positioning Attribute;practice-based research network;Prevalence;prevention practice;Prevention program;prevention service;Primary Care;primary care practice;primary care provider;Procedures;programs;Protocols documentation;Provider;provider adoption;provider-level barriers;Public Health;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Reporting;Resources;Risk;Risk Assessment;Risk Management;routine care;Safety;screening;Services;skills;suicidal;suicidal risk;Suicide;Suicide attempt;Suicide prevention;sustainability framework;System;Testing;tool;Training;United States;Visit;Work;Youth

PROJECT_TITLE: Practice Facilitation to Enhance Implementation of a Pediatric Suicide Prevention Care Pathway

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (07)]


ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: Project Narrative Alcohol-associated liver disease (ALD) is a major public health problem among veterans. This application examines the mechanisms by which the pyruvate dehydrogenase kinase 4 (PDK4) and mitochondrial- associated ER membrane (MAM) mediates the pathogenesis of alcohol-induced liver injury. The results of our application have the potential to identify a new therapeutic approach for ALD by targeting PDK4.

PI_NAMEs: LIANGPUNSAKUL, SUTHAT  (contact)

PROJECT_TERMS: adverse outcome;Affect;Alcohol consumption;alcohol effect;alcohol related problem;alcohol risk;Alcoholic Liver Diseases;Alcohols;Binding;Biological Assay;Cell Fractionation;chronic liver disease;clinical application;comparison control;Complex;Data;Disease;disease model;drinking;Electrons;Endoplasmic Reticulum;Ethanol;experimental study;fatty acid oxidation;Future;Generations;Genes;glucose-regulated proteins;Goals;Health;Hepatic;Hepatocyte;In Situ;In Vitro;in vivo;Inositol;ITPR1 gene;Ligation;Link;Liver;Liver diseases;liver transplantation;Mediating;Membrane;Mitochondria;mitochondrial dysfunction;Mitochondrial Membrane Protein;mitochondrial metabolism;Molecular;Molecular Chaperones;Mus;novel;novel therapeutic intervention;Outer Mitochondrial Membrane;Paraffin Embedding;Pathogenesis;Pathway interactions;Patients;Phosphorylation;prevent;Process;Production;protective effect;protein complex;Proteins;Public Health;pyruvate dehydrogenase kinase 4;receptor;Reporting;Risk Factors;Role;Series;Signal Transduction;Site;Tissues;transcriptome sequencing;transcriptomics;transmission process;tripolyphosphate;Veterans;Voltage-Dependent Anion Channel

PROJECT_TITLE: Mechanism of PDK4 and MAM axis in alcohol-associated liver disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 GAST-L (01)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences

PHR: Project Narrative Highly localized kinase signaling in brain learning/memory circuits is genetically dissected using separation of phases-based activity reporter of kinase (SPARK) biosensors for in vivo imaging. We use PKA-, ERK- and CaMKII-SPARK to test activity-dependent, interactive mechanisms. Conversely, we test kinase regulation of circuit activity, studying bidirectional effects in normal animals as well as an epilepsy seizure model.

PI_NAMEs: BROADIE, KENDAL  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Animals;Behavior;Behavioral;Behavioral Assay;behavioral impairment;Biogenic Amines;Biological Assay;Biosensor;Brain;calmodulin-dependent protein kinase II;Cell Culture Techniques;Cells;Cyclic AMP-Dependent Protein Kinases;Data;Defect;disease model;Dissection;Drosophila genus;Engineering;Epilepsy;Equilibrium;experience;Extracellular Signal Regulated Kinases;Functional disorder;gain of function;Genetic;Goals;Human;Image;imaging study;improved;in vivo;in vivo evaluation;in vivo imaging;Individual;Learning;Ligands;loss of function;Maps;Memory;memory consolidation;Memory impairment;Modeling;Mushroom Bodies;mutant;neuronal circuitry;Neurons;Neuropeptides;neuroregulation;neurotransmission;novel;optogenetics;Output;Pathway interactions;Performance;Pharmacologic Substance;Pharmacological Treatment;Pharmacology;Phase;Phosphotransferases;Predisposition;Publishing;receptor;Regulation;Reporter;RNA Interference;Role;Seizures;Sensitivity and Specificity;Signal Pathway;Signal Transduction;Synapses;synaptic function;Testing;Tetanus Toxin;tool;Transgenic Organisms;Visualization;Work

PROJECT_TITLE: In Vivo Analyses of Kinase Signaling in Learning/Memory Circuitry


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Microbiome

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The yeast Candida albicans is a normal resident of the human digestive tract and also one of the most common fungal pathogens of humans, causing both mucosal and systemic infections, particularly in immune compromised patients. This proposal seeks to understand how a deeply-conserved feature of Candida albicans—white-opaque switching—occurs in mechanistic terms and how it contributes to Candida’s ability to infect mammals. White-opaque switching enables two very different types of cells—each of which is stable through many rounds of cell division—to be produced from the same genome.

PI_NAMEs: JOHNSON, ALEXANDER D (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Accounting;Affect;Auxins;Behavior;Biological Assay;Biological Process;burden of illness;Candida;Candida albicans;Cell division;cell type;Cells;Clinical;clinically relevant;Data;Devices;Disease;DNA Modification Process;Environment;Epigenetic Process;Event;Feedback;Fluorescence;Fluorescence Microscopy;Gastrointestinal tract structure;Generations;Genes;Genetic Transcription;Genome;Goals;Growth;gut colonization;histone modification;Human;Human Microbiome;human pathogen;Immune;In Vitro;Individual;Infection;Injections;Laboratories;Life;Maintenance;Mammals;Memory;Microfluidics;Modeling;Molecular;Morphology;mouse model;Mucous Membrane;Mus;mutant;Organism;oropharyngeal thrush;pathogenic fungus;Patients;Play;Proliferating;Regulation;Reporter;response;Role;Series;Sterility;Symbiosis;System;Systemic infection;Tail;Technology;Testing;Time;Veins;Virulence;Work;Yeasts

PROJECT_TITLE: Mechanisms of White-Opaque Switching in Candida albicans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-M (02)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: AUSTIN

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PUBLIC HEALTH RELEVANCE STATEMENT The ability to perform dynamic imaging of time-varying physiological processes in small animal models is critically needed to understand the progression of human disease and develop new therapies. This research will transform photoacoustic tomography into what has been promised for several decades—a quantitative imaging modality for dynamic functional and molecular imaging. The developed computational technologies will find widespread application in preclinical medicine and have immediate and sustained positive impact on preclinical science.

PI_NAMEs: VILLA, UMBERTO  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 3-Dimensional;4D Imaging;absorption;Acoustics;Address;animal imaging;Animal Model;Animals;anti-cancer;Biological Markers;Biological Models;Blood Vessels;chromophore;contrast enhanced;Contrast Media;design;Development;Diffusion;dimension reduction;Dimensions;Drug Kinetics;Four-dimensional;Functional Imaging;Hemoglobin;human disease;Image;Image Enhancement;image reconstruction;imager;imaging modality;imaging study;improved;in vivo;Maps;Measurement;Measures;Mechanics;Medicine;Methods;Modeling;molecular imaging;Mus;novel;novel therapeutics;Optics;optoacoustic tomography;Penetration;Perfusion;Photons;Physiological Processes;pre-clinical;preclinical imaging;pressure;Process;Property;public health relevance;quantitative imaging;reconstruction;Research;Resolution;Rotation;Scanning;Science;Slice;spectrograph;System;Technology;Three-Dimensional Image;Time;tomography;tool;Transducers;tumor;two-dimensional;virtual imaging;X-Ray Computed Tomography

PROJECT_TITLE: Advancing three-dimensional preclinical dynamic contrast-enhanced photoacoustic computed tomography via quantitative image reconstruction

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSURGERY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative (3 sentences max) This project builds the CAMERA (Context-Aware Multimodal Ecological Research and Assessment) platform, which will fuse diverse data signals from a range of unobtrusive sensors to continuously predict transient internal states and level of cognitive function. This project will identify new features of human neural activity, physiology, behavior, and environment related to memory and anxiety (R61), and test whether we can use multimodal data to more accurately identify and modulate anxiety and memory performance states (R33). CAMERA will also open a pathway towards the use of multimodal data and machine learning for naturalistic research and translational studies related to other complex human internal states and behaviors.

PI_NAMEs: JACOBS, JOSHUA  (contact);ORTIZ, JORGE ;WIDGE, ALIK S.;YOUNGERMAN, BRETT E

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Acoustics;adaptive learning;Anxiety;anxiety states;Awareness;Behavior;behavior measurement;Behavioral;Behavioral Mechanisms;Biological Markers;Brain;brain behavior;Cellular Phone;Classification;Clinical;Cognition;cognitive function;cognitive performance;Complex;Data;data framework;data modalities;Data Sources;deep learning;diverse data;Ecological momentary assessment;Electrodes;Emotional;Environment;Epilepsy;explainable machine learning;flexibility;Frequencies;Generations;Heart Rate;Hippocampus;Human;improved;innovation;Inpatients;Interruption;Learning;Linguistics;Machine Learning;Measurement;Measures;Memory;memory process;Methods;Modeling;Monitor;multimodal data;multimodality;Natural Language Processing;neural;Neurons;novel;Outcome Assessment;Pathway interactions;Patient Self-Report;Patients;Performance;Persons;Phase;Physiological;Physiology;predictive modeling;Process;Production;Psychological reinforcement;Research;research study;Resolution;response;self-reported anxiety;sensor;Signal Transduction;Software Framework;software systems;Startle Reaction;System;Testing;Text;Time;tool;transfer learning;translational potential;translational study;Visuospatial;Work;wristband

PROJECT_TITLE: Developing the Context-Aware Multimodal Ecological Research and Assessment (CAMERA) Platform for Continuous Measurement and Prediction of Anxiety and Memory State

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-E (01)]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Radiation Oncology;Rare Diseases

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative Current diagnosis of diffuse gliomas necessitates a high-risk neurosurgical procedure for direct tissue acquisition, which offers limited information due to significant intra-tumoral spatial heterogeneity. The cerebrospinal fluid is in direct contact with the tumor and its microenvironment, which can be leveraged for identification of comprehensive proteogenomic signatures of both diagnosis and inform management. The work proposed here aims to develop and validate proteogenomic signatures for diffuse glioma diagnosis while also resolving challenges during patient follow-up, and establish the first-ever glycoproteomic profile in CSF of glioblastoma based on the largest prospective CSF cohort in diffuse gliomas to date, which will lead to a significant paradigm shift in their management.

PI_NAMEs: MANSOURI, ALIREZA  (contact)

PROGRAM_OFFICER_NAME: GANGULY, ANIRUDDHA

PROJECT_TERMS: Address;Adjuvant Therapy;Adult;Affect;Biological Assay;Biological Markers;biomarker validation;Blood;Brain;Brain Neoplasms;Cell surface;Central Nervous System Lymphoma;Cerebrospinal Fluid;Characteristics;Classification;Clinical;clinical decision-making;Clinical Trials;clinically relevant;cohort;Counseling;Cytometry;Data;Databases;Demyelinations;Development;Diagnosis;diagnostic signature;Differential Diagnosis;Diffuse;Drug Targeting;druggable target;Early Intervention;Epidermal Growth Factor Receptor;epigenome;Excision;FDA approved;follow-up;Future;Genome;genomic biomarker;Glioblastoma;Glioma;Glycopeptides;Glycoproteins;glycoproteomics;glycosylation;Guidelines;Heterogeneity;high risk;Image;Imaging Techniques;improved;Individual;insight;Lesion;liquid biopsy;Liquid substance;machine learning classifier;Magnetic Resonance Imaging;Malignant - descriptor;Malignant neoplasm of brain;Malignant neoplasm of ovary;Malignant Neoplasms;Mass Spectrum Analysis;Metastatic malignant neoplasm to brain;Methods;Methylation;MGMT gene;minimally invasive;Modeling;Molecular;Molecular Analysis;Molecular Evolution;Monitor;Multicenter Studies;mutant;Neoadjuvant Therapy;Neurosurgical Procedures;new therapeutic target;non-invasive imaging;Normal Pressure Hydrocephalus;novel;novel diagnostics;novel marker;Operative Surgical Procedures;Pathway interactions;Patients;Performance;personalized diagnostics;Persons;Phenotype;Physiological;Prognosis;prognostic signature;programmed cell death ligand 1;prospective;Prospective cohort;Protein Secretion;proteogenomics;proteomic signature;Proteomics;Radiation necrosis;Radiology Specialty;Reaction;Recurrence;Recurrent tumor;risk mitigation;Sampling;Sampling Biases;Serous;Shotguns;single-cell RNA sequencing;Source;Standardization;success;surveillance strategy;Taxonomy;Testing;Tissue Sample;Tissues;transcriptome;treatment response;tumor;Tumor Markers;Tumor Tissue;Unnecessary Surgery;Validation;Work

PROJECT_TITLE: Integration of CSF Proteogenomics in the Diagnosis and Management of Diffuse Gliomas

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE  The proposed study will expand an existing longitudinal study (DZC-1), the first panel survey of reproductive lives in Brazil of any kind, to lengthen the observation interval of respondents by three years stands to generate one of the longest empirical records for examining the reproductive lives of a multiage (18- 34 in 2020) cohort of women (and their children) in response to highly consequential successive novel infectious disease crises. With established rapport with the community and instituted local survey capacity in an epicenter of Zika and Covid-19, our proposed approach advances critical knowledge on the extent to which Covid-19, and successive generalized epidemics, which have become increasingly common, are consequential to women's reproductive lives, including their young children's health. The findings promise to advance research and theory on successive novel infectious disease shocks by examining individual- and contextual-level effects on women's reproductive lives and trajectories, which can inform policy and outreach efforts to reduce unmet need for contraception and unintended fertility amidst major reproductive health crises.

PI_NAMEs: MARTELETO, LETICIA J (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Age;Back;Behavior;Binding;Birth;Birth Weight;Brazil;Censuses;Characteristics;Child;child bearing;Child Health;Cicatrix;Classification;cohort;Cohort Analysis;Communicable Diseases;Communities;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Country;COVID-19;COVID-19 pandemic;Data;Data Collection;data infrastructure;Data Set;Death Rate;design;Desired Family Sizes;Developing Countries;Disease;disease transmission;Economics;Epidemic;experience;Family;Fertility;Geographic Locations;Goals;Health;health care availability;Income;Individual;Inequality;infection risk;innovation;insight;Interview;Knowledge;Life Cycle Stages;Link;longitudinal dataset;Longitudinal Studies;Longitudinal Surveys;Marital Relationships;Mediator;member;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;Municipalities;Nature;novel;Outcome;outreach;pandemic disease;pandemic potential;Pathway interactions;Pattern;Personal Satisfaction;Policies;population based;population health;post-COVID-19;Postnatal Care;preference;Pregnancy;prenatal;psychosocial;Public Health;Race;Recording of previous events;Records;Recurrence;reproductive;Reproductive Behavior;Reproductive Health;Reproductive History;reproductive outcome;Reproductive Process;Research;Respondent;response;Risk;risk perception;Sampling;SARS-CoV-2 infection;Scientist;Security;Self Efficacy;Shapes;Shock;Social Network;sociodemographics;spatiotemporal;Surveys;Testing;theories;Time;unintended pregnancy;unvaccinated;Vaccinated;vaccine access;Variant;Vulnerable Populations;Woman;Women's cohort;Women's study;Work;ZIKA

PROJECT_TITLE: Reproductive and Child Health Trajectories in Successive Novel Infectious Disease Crises

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Endocrine Disruptors;Genetics

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE This proposal seeks to understand how chemical pollutants such as dioxins and aromatic hydrocarbons cause toxic effects. Such pollutants cause their toxic effects by activating a protein called the aryl hydrocarbon receptor, and we seek to understand how this protein communicates with other proteins and with DNA to cause toxic effects in the liver. Our results will improve our ability to predict how exposure to dioxins or related pollutants will affect human health.

PI_NAMEs: GORELICK, DANIEL  (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Affect;ARA9 protein;ARNT gene;Aromatic Hydrocarbons;Aromatic Polycyclic Hydrocarbons;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Atrophic;Binding;Binding Proteins;Biochemical;Biology;Chemicals;ChIP-seq;chromatin immunoprecipitation;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Communication;Complex;Consensus;Cultured Cells;Data;Dimerization;Dioxins;Disparate;DNA;DNA Binding;DNA receptor;DNA Sequence;Electrophoretic Mobility Shift Assay;Embryo;Enhancers;Environment;Environmental Exposure;Exposure to;functional genomics;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genomic approach;genomic locus;Genomics;Health;Hepatocyte;Human;Immunoprecipitation;improved;In Vitro;in vivo;Industrialization;Ligands;Liver;Location;loss of function mutation;Maps;Mass Spectrum Analysis;Mediating;model organism;Mouse Protein;Mus;Mutagenesis;mutant;Mutant Strains Mice;Mutate;Mutation;Nucleic Acid Regulatory Sequences;Pathway interactions;Physiological;pollutant;promoter;Proteins;receptor;receptor binding;Receptor Signaling;recruit;Regulatory Element;response;Response Elements;Role;Testing;Tetrachlorodibenzodioxin;Thymus Gland;Toxic effect;transcription factor;transcriptome sequencing;tumorigenesis;Xenobiotics;Zebrafish

PROJECT_TITLE: INVESTIGATING ARYL HYDROCARBON RECEPTOR-COFACTOR INTERACTIONS THAT MEDIATE TOXICITY

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Precision Medicine;Rehabilitation

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative New technologies have the potential to transform interventions for speech sound disorder, a high-prevalence condition that negatively impacts social and academic participation, but there is a lack of rigorous evidence to substantiate this promise. This research will meet a public health need by systematically evaluating the efficacy of visual-acoustic biofeedback intervention delivered in-person versus via telepractice and assessing the potential for maintenance of treatment gains to be enhanced through home practice with artificial intelligence (AI)-mediated feedback. It will also test the hypothesis that the efficacy of intervention can be optimized when the choice of biofeedback technology is personalized to match the learner’s profile of sensory strengths and limitations.

PI_NAMEs: MCALLISTER, TARA  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Address;Administrative Supplement;Adolescence;Adopted;Adoption;Adult;Affect;Age Years;Articulators;Artificial Intelligence;Artificial Intelligence enhanced;Auditory;Biofeedback;Biofeedback Training;Blinded;Child;Childhood;Clinical;clinical decision-making;clinical implementation;Clinical Management;clinical practice;Clinical Trials;clinically relevant;Collaborations;Communication;community based treatment;Complement;Computer Models;cost;Data;data analysis pipeline;Development;Disease;efficacy evaluation;efficacy testing;Emotional;Enhancement Technology;Equipment;evidence base;Exhibits;Family;Feedback;Funding;High Prevalence;Home;Individual;insight;Intervention;intervention delivery;Language;Learning;life span;Link;Maintenance;Manuals;Measures;Mediating;Methods;Modeling;Modernization;new technology;Occupational;open data;Oral;Outcome;Participant;Pathologist;Patients;peer;Persons;Phase;precision medicine;predicting response;Prediction of Response to Therapy;Procedures;Productivity;Provider;Public Health;Publishing;Randomized;Readiness;recruit;remote delivery;Reporting;Research;Research Design;research study;Residual state;response;School-Age Population;Sensory;sensory feedback;service delivery;Services;social;social engagement;somatosensory;Speech;speech accuracy;Speech Disorders;Speech Sound;Study models;support tools;System;Technology;technology validation;Testing;Time;tool;Training;treatment as usual;Treatment Efficacy;tutoring;ultrasound;United States National Institutes of Health;user-friendly;Visual;visual information;Work

PROJECT_TITLE: Biofeedback-Enhanced Treatment for Sensorimotor Learning in Speech Sound Disorders: Clinical Trial and Delineation of Subtypes

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Type 3 transformation zone (TZ), which accounts for about 15% of women, impedes the effectiveness of cervical cancer screening with visual inspection with acetic acid (VIA), by limiting full visualization of the TZ. This study will evaluate the effectiveness of intravaginal misoprostol in converting Type 3 TZ (complete visualization of the TZ), reducing the likelihood of missed lesions. If successful, the results will be applied to cervical cancer screening programs in low-and-middle-income countries to improve the outcome of VIA when used as a standalone test or as a triage to HPV-DNA screening.

PI_NAMEs: HUH, WARNER KING (contact);MANGA, SIMON

PROGRAM_OFFICER_NAME: SAHASRABUDDHE, VIKRANT V

PROJECT_TERMS: Acetic Acids;Address;Africa;Africa South of the Sahara;Age;Alprostadil;arm;Benign;Cameroon;Cancer Etiology;cancer prevention;Cancerous;Cervical;cervical cancer prevention;Cervical Cancer Screening;Cervix Neoplasms;Cervix Uteri;Clinical;clinical practice;cost;Country;Data;Detection;Diagnosis;digital;Discipline of obstetrics;DNA;Dose;Double-Blind Method;Early treatment;Effectiveness;effectiveness evaluation;effectiveness testing;Endocervical Curettage;Equipment;Evaluation;Failure;follow-up;Future;Goals;Health Personnel;high risk;Hour;HPV screening;Human Papillomavirus;improved;improved outcome;Income;Intervention;Interview;Intravaginal Administration;Lesion;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maternal Age;Menopausal Status;Menopause;Misoprostol;Morbidity - disease rate;mortality;parity;Participant;Patients;Placebos;Positive Test Result;premalignant;prevent;Prevention;Prevention program;primary outcome;programs;Provider;Publishing;randomized trial;Recommendation;Resource-limited setting;response;Risk;Risk Reduction;Sampling;satisfaction;screening;screening program;secondary outcome;side effect;Structure;Suggestion;Testing;treatment duration;Triage;Vagina;Visit;Visual;Visualization;Vitamin B6;Woman;Women's Health;women's morbidity;Women's mortality;Work;World Health Organization

PROJECT_TITLE: Misoprostol to Optimize Prevention of Cancer of the Cervix: A Randomized Trial (MISOPCx Project)

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]