NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Estrogen;Neurosciences;Prevention;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE Effective use of hormonal contraception is frequently limited by behavioral side effects, such as changes in mood and decreases in sexual desire. These side effects may be attributable to the ways hormonal contraception impacts brain functions related to motivation and pleasure, known as “reward function.” This project will use a placebo-controlled design to evaluate the effects of hormonal contraception on reward function, with the goal of creating a protocol that will enhance personalization of contraceptive treatment, allowing clinicians and patients to better choose agents with the least propensity for behavioral side effects.

PI_NAMEs: NOVICK, ANDREW MICHAEL (contact)

PROGRAM_OFFICER_NAME: LINDSEY, CHRISTOPHER CHARLES

PROJECT_TERMS: Acute;Affect;aged;Allopregnanolone;analog;Androgens;Animals;arm;Behavior;Behavior assessment;Behavioral;behavioral health;Biological;blood oxygen level dependent;Brain;career;Central Nervous System;Clinical;Clinical Trials;Collaborations;Colorado;Contraceptive Agents;Contraceptive methods;Decision Making;design;discontinuation study;Doctor of Medicine;Erotica;Estradiol;Ethinyl Estradiol/Levonorgestrel;experience;Feeling;Female;follow-up;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Gonadal Steroid Hormones;Health;hedonic;hormonal contraception;Human;Image;improved;Incidence;Individual;innovation;interest;Investigation;Levonorgestrel;Libido;life span;Link;Luteal Phase;Measures;Medial;Medical;Menstrual cycle;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Monitor;Moods;Motivation;National Institute of Child Health and Human Development;negative mood;neural;neurobehavioral;Neurobiology;neuroimaging;neuropsychopharmacology;Neurosciences;Nucleus Accumbens;open label;Oral Contraceptives;Participant;Patient Self-Report;Patients;personalized medicine;Pharmaceutical Preparations;Phase;pill;Placebo Control;placebo group;Placebos;pleasure;positive mood;pre-clinical research;Predictive Value;Prefrontal Cortex;Process;professor;Progesterone;proliferative phase Menstrual cycle;prospective;Protocols documentation;Psychoneuroendocrinology;Randomized;recruit;Reporting;reproductive;Research;Research Personnel;Resources;responsible research conduct;reward processing;Rewards;Risk;Risk Factors;Sample Size;Sex Functioning;side effect;Signal Transduction;skills;Statistical Models;steroid analog;Steroids;Survivors;Techniques;Testing;Time;Training;trial design;unintended pregnancy;Universities;Woman;Women's study;Writing

PROJECT_TITLE: Neurobiology of hormonal contraception

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Among fall related injuries in older adults, head injuries are the most common, yet almost nothing is known about recovery from head injury, also known as traumatic brain injury or TBI, in this population. The objective of the proposed research is to conduct a prospective cohort study of 250 adults aged 65 and older with mild TBI to evaluate recovery in cognitive, physical and psychological function and sleep quality at four timepoints over the year following injury and identify factors associated with recovery trajectories. The potential impact of this work is that it will generate new knowledge to guide targeted treatment efforts and inform future development of strategies to optimize recovery following this common fall-related injury among older adults.

PI_NAMEs: ALBRECHT, JENNIFER S. (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: acute care;Adult;adverse outcome;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Caring;Characteristics;Cognition;Cognitive;cognitive function;cognitive recovery;cognitive rehabilitation;comorbidity;Craniocerebral Trauma;Data;dementia risk;Development;Early identification;Elderly;Emergency department visit;experience;fall injury;falls;follow-up;Frontotemporal Dementia;Future;Health;Heterogeneity;high risk;Hospitalization;human old age (65+);Impaired cognition;Impairment;improved;Individual;Injury;Intervention;Knowledge;Literature;long term recovery;Lower Extremity;Measures;mild traumatic brain injury;Modeling;older adult;Outcome;Participant;Patients;Pattern;Physical Function;Pilot Projects;Population;Prospective, cohort study;psychologic;psychological distress;Public Health;Recovery;Rehabilitation therapy;Research;Risk;Shock;Signal Transduction;sleep quality;targeted treatment;trauma centers;Traumatic Brain Injury;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Recovery among Older Adults Following Head Injury

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Schizophrenia

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE: Loss of spatial memories may be one of the most distressing symptoms of neurological disorders such as Alzheimer’s disease and psychiatric disorders such as schizophrenia. Patients with Alzheimer’s disease may struggle to remember landmarks or form cognitive maps of their environment; patients with schizophrenia may struggle with sensory integration, leading to perceptual disturbances and impairments in spatial working memory. This project will characterize cellular- and circuit-level mechanisms of spatial integration, which will lead to a better understanding of how these processes malfunction in disease.

PI_NAMEs: JANKE, ABIGAIL MARIE (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's disease patient;Behavioral;Brain;Calcium;Calcium Signaling;Cell Physiology;Circadian Rhythms;Cognition;Cognitive;cognitive function;Complex;Consumption;Disease;Distress;Drops;Drosophila genus;Endoplasmic Reticulum;Environment;Event;experimental study;Feedback;fly;Food;Health;High Prevalence;Human;Image;Impaired cognition;Impairment;improved;Injections;insight;interest;Interneurons;Ion Channel;Knowledge;Location;Maps;Measures;Mediating;member;Membrane Potentials;Memory;Mental disorders;Modeling;Motor;Nervous System Disorder;neural;Neurologic Symptoms;Neurons;Neurosciences;neurotransmission;optogenetics;Pathologic;Patients;Perceptual disturbance;Pharmacological Treatment;Play;Positioning Attribute;Process;Recurrence;release of sequestered calcium ion into cytoplasm;Schizophrenia;Sensory;sensory integration;Short-Term Memory;Signal Transduction;Sleep Disorders;Source;spatial integration;spatial memory;Speed;sugar;Sum;Symptoms;Synapses;System;Testing;Time;Travel;vector;Visual;Walking;way finding;Work

PROJECT_TITLE: How neural signals are integrated over time


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy;Prevention;Skin Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HERSHEY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE: Over the long-term, this significant and innovative research will determine the efficacy of targeting the ALDH protein family to inhibit recurrent resistant disease development mediated by cancer stem cells and improve the efficacy of checkpoint antibody immunotherapy to increase the number of melanoma patients responding to this treatment regimen. Therefore, the impact on cancer mortality rates could be significant.

PI_NAMEs: ROBERTSON, GAVIN P. (contact);SCHELL, TODD D

PROGRAM_OFFICER_NAME: VLAD, ANDA MIOARA

PROJECT_TERMS: aldehyde dehydrogenases;Aldehydes;Animals;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;Antibodies;antibody immunotherapy;Biological Response Modifiers;cancer cell;cancer prevention;cancer stem cell;Carboxylic Acids;CD8-Positive T-Lymphocytes;Cell Line;Cell Physiology;Cell Survival;cell type;Cells;Characteristics;chemotherapy;clinical translation;clinically relevant;Cultured Cells;Data;Death Rate;Dendritic Cells;Development;Disease Resistance;Drug Combinations;Drug resistance;drug resistance development;Drug Targeting;Effector Cell;efficacy evaluation;efficacy testing;enzyme activity;Enzymes;Exhibits;Family member;Flow Cytometry;Genetic;genetic approach;Immune;immune function;Immune response;immunogenic cell death;immunoregulation;Immunosuppression;Immunotherapy;improved;Individual;inhibitor;innovation;Isatin;Knock-out;Lethal Dose 50;Link;Malignant Neoplasms;Measures;Mediating;Melanoma;Melanoma patient;Melanoma Tumor;Modeling;mouse model;Mus;nanoparticle;Natural Killer Cells;Natural Products;Neoplasm Metastasis;neoplastic cell;novel;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacotherapy;Population;pre-clinical;preclinical efficacy;prevent;Process;Protein Family;Protein Isoforms;Proteins;Qualifying;Recurrence;Regulatory T-Lymphocyte;Research;Resistance;Resistance development;response;Role;Signal Transduction;stem cell biomarkers;stem cell population;stemness;T-Lymphocyte;targeted agent;Testing;Therapeutic;Toxic effect;Treatment Efficacy;Treatment Protocols;Tretinoin;tumor;tumor microenvironment;tumor-immune system interactions;Validation;Vertebral column

PROJECT_TITLE: Targeting Aldehyde Dehydrogenase for Cancer Prevention

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Services;Human Genome

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE The overall purpose of this national training program is to prepare doctoral nurses, including those with a Doctor of Nursing Practice (DNP) and/or a Philosophy Doctorate (PhD), to translate and integrate genetic and genomic content into doctoral nursing academic curricula, scholarship and practice. The foundations for this medical genomics educational training program include: Genomic Nursing Competency Implementation Strategic Plan 2014-20203, the Genomic Essential Genetic and Genomic Competencies for Nurses with Graduate Degrees4, and the Essentials of DNP Education5. The primary aims will be achieved through a half- day genomics course offered at an annual national doctoral nursing conference each January, followed by monthly webinars/web conferences through the remainder of the year to sustain interest, engage learners, and create a community of learners to become genomic nursing doctoral champions for their nursing school.

PI_NAMEs: CONNORS, LAURIE M (contact)

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Address;Advocacy;American;Area;California;career networking;Caring;Clinical;clinical care;clinical practice;Collaborations;college;Communication;Communities;Competence;Consultations;Continuing Education;Discipline of Nursing;Doctor of Philosophy;Doctor's Degree;Education;education planning;Education Projects;Educational Curriculum;Educational Models;Educational process of instructing;Evaluation;evidence base;expectation;experience;Faculty;Family;Florida;Foundations;Future;Genetic;genome sciences;Genomic medicine;Genomics;Goals;Graduate Degree;Health;health care delivery;health care service;Health Personnel;Health Policy;Healthcare;Healthcare Systems;Hour;implementation barriers;improved;Institute of Medicine (U.S.);interest;Internet;Knowledge;Labor Forces;Lead;Leadership;Measures;Medical;Modeling;Needs Assessment;next generation;Nurses;Nursing Education;Nursing Faculty;Nursing Schools;Nursing Students;online resource;Outcome;Participant;Patient Care;Peer Review;peer support;personalized health care;Philosophy;Program Evaluation;programs;Psychological reinforcement;Publications;Reporting;Research;Research Personnel;Resources;Review Literature;Scholarship;School Nursing;skills;Slide;Strategic Planning;Students;success;symposium;tool;Trainers Training;Training;Training and Education;Training Programs;Translating;translational genomics;Translations;United States;Universities;webinar;Writing

PROJECT_TITLE: Translation and Integration of Genomics is Essential to Doctoral Nursing: "TIGER"

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative The proposed research is relevant to public health as it investigates a potential therapy for treating disrupted control of organ and muscle blood flow following traumatic spinal cord injury. Without control of these functions, patients with spinal cord injury live with a number of number of deficits, including an inability to appropriately redistribute blood, muscle fatigue, and exercise intolerance. Thus, this proposal is relevant to the NIH’s mission, as it seeks to discover a new therapy via research that is highly relevant for human health.

PI_NAMEs: GANZER, PATRICK D (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Address;Affect;Animals;Area;Baroreflex;Behavior;Blood;Blood flow;Cardiovascular Physiology;Cardiovascular system;Cell Nucleus;Cervical spinal cord injury;cholinergic;Data;Dedications;effective therapy;Electrophysiology (science);Event;exercise intolerance;experience;experimental group;experimental study;Forelimb;Functional disorder;Goals;Health;Human;Hypothalamic structure;improved;Investigation;Lateral;mad itch virus;Maps;Measures;microstimulation;Mission;Modeling;Motor;motor control;Movement;multidisciplinary;Muscle;Muscle Fatigue;Muscle function;Nervous System Trauma;neural circuit;Neural Pathways;Neuroanatomy;Neuromodulator;Neuronal Plasticity;neuroregulation;neurotransmitter release;novel therapeutics;Organ;Paralysed;Pathway interactions;Patients;Perfusion;Peripheral;Physiology;Prosencephalon;Public Health;Rattus;Recovery;Rehabilitation therapy;Research;Resistance;simulation;Spinal Cord;Spinal cord injury;Stroke;Synapses;System;Techniques;Technology;Testing;Therapeutic;Time;Tissues;Training;translational potential;Travel;United States Food and Drug Administration;United States National Institutes of Health;Upper Extremity;Upper limb movement;vagus nerve stimulation;Work

PROJECT_TITLE: Enhancing Sympathetic Outflow Control Following Spinal Cord Injury Using Targeted Plasticity Therapy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Patient Safety;Women's Health Research

ORG_CITY: EVANSTON

ORG_NAME: ENDEAVOR HEALTH CLINICAL OPERATIONS

ORG_STATE: IL

PHR: Obstructed defecation (OD), defined as incomplete emptying of stool, is a widely prevalent disorder in women’s health, occurring in roughly 25% of constipated women and resulting in major quality of life (QOL) and healthcare burdens. Our group has developed a cheap, bedside diagnostic approach for OD that better identifies patients that need surgery, and a minimally invasive, mesh-free surgical approach to treat those patients that causes less morbidity, and improves outcomes based on our small preliminary studies. The goal of this proposal is to do a more extensive clinical trial to demonstrate the effectiveness of these approaches.

PI_NAMEs: ROSTAMI NIA, GHAZALEH  (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: Abdomen;Adult;Anatomy;Anus;Ataxia;Caring;Case Series;Chronic;Clinic;Clinical;Clinical Data;Clinical Trials;Computer Models;Constipation;Data;Dedications;Defecation;Defecography;Defect;design;Diagnosis;Diagnostic;Diagnostic Procedure;diagnostic strategy;Disease;Effectiveness;Elements;Evaluation;Feces;follow-up;Foundations;Frequencies;Goals;health related quality of life;healthcare burden;Impairment;implantation;improved;improved outcome;insight;Institution;Intestines;Ligaments;Magnetic Resonance Imaging;Manometry;Manuals;Measures;Mechanics;Methods;minimally invasive;Modality;Modeling;Morbidity - disease rate;novel;novel diagnostics;novel strategies;operation;Operative Surgical Procedures;Patients;Pelvic floor structure;Pelvis;Physics;pressure;primary outcome;Procedures;prospective;Ptosis;Publications;Publishing;Quality of life;Randomized;Rectal Prolapse;Rectocele;Rectum;repaired;Research;Role;secondary outcome;Shapes;Source;standard of care;Surgical incisions;Symptoms;Testing;Treatment outcome;Ultrasonography;ultrasound;Vagina;Vaginal Prolapses;Woman;women subjects;Women's Health;women's outcomes;Work

PROJECT_TITLE: Prospective RCT of Obstructed Defecation Surgery: Comparing Transvaginal Rectopexy, Ventral Mesh Rectopexy and POP Repair (PROD Trial)

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SALT LAKE CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative More than 7 million people in the U.S. and Europe have atrial fibrillation. MRI offers methods to give information about the left atrium that help with clinical management decisions. This proposal offers new methods using MRI to better assess the heart and to determine if these measurements are more reproducible for an individual than previous MRI methods.

PI_NAMEs: DIBELLA, EDWARD VR (contact);ELHABIAN, SHIREEN YOUSSEF;KHOLMOVSKI, EUGENE ;RANJAN, RAVI

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Ablation;Adult;Affect;Age;Atrial Fibrillation;automated segmentation;biomedical imaging;Biopsy;Blood;canine model;Cardiac;Cardiology;Cardiovascular Diseases;Cardiovascular system;Caring;catalyst;Cicatrix;Clinical;clinical investigation;Clinical Management;Clinical Sciences;Collagen;Compensation;computer framework;Computing Methodologies;coronary fibrosis;Data;Data Set;deep learning;Detection;Development;Diffuse;Disease;Economics;Emergency department visit;Europe;experience;Fibrosis;Future;Gadolinium;Goals;Health Care Costs;Health system;Heart;Heart Atrium;heart imaging;heart motion;heart rhythm;high resolution imaging;Histology;Hospitalization;Human;Hypertension;Image;Image Analysis;Image Enhancement;image reconstruction;Imaging Device;imaging modality;Imaging Techniques;improved;in vivo;Individual;Injury;innovation;Intervention;Investigation;Left;Left atrial structure;Machine Learning;machine learning method;Magnetic Resonance Imaging;Measurement;Measures;Medical;Methodology;Methods;Modeling;mortality;Motion;Myocardium;Nature;non-invasive imaging;novel;Office Visits;open data;open source;open source tool;Patients;Persons;Play;Population;Prevalence;Problem Solving;Process;Protocols documentation;reconstruction;Reproducibility;Research;Research Personnel;Resolution;Respiration;respiratory;Scanning;Sinus;Specialist;Standardization;stroke risk;Structure;Supervision;Techniques;Technology;Testing;Thinness;Time;Tissues;tool;Trichrome stain;United States;usability;Visualization;Work

PROJECT_TITLE: Improved Imaging of Fibrosis in Atrial Fibrillation


NIH_SPENDING_CATS: Biotechnology;Estrogen;Genetics;Kidney Disease;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Acute kidney injury (AKI) impacts 1.2 million hospitalized patients in the US annually and affects males more severely than females. Our proposed studies will determine the sex-dependent mechanisms for AKI and its recovery. Knowledge of these mechanisms will allow the development of new therapies to improve the recovery of kidney functions after AKI for both sexes.

PI_NAMEs: SOUMA, TOMOKAZU  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acceleration;Acute;Acute Renal Failure with Renal Papillary Necrosis;Affect;Attenuated;Cardiovascular system;Cell Culture Techniques;Cell Death;Cell membrane;Cells;Cessation of life;Chronic;Chronic Kidney Failure;Clinical;COVID-19;Data;Dependence;design;Development;Dialysis procedure;Disease;Doxycycline;early experience;Environment;epithelial injury;ESR1 gene;Estrogen Receptors;Estrogens;Event;Exhibits;Female;female sex hormone;Fibrosis;Genetic;glutathione peroxidase;Gonadal Steroid Hormones;GPER gene;Health;high risk;Histopathology;Hormonal;Hospitalization;Human;Immune;Immune response;Impairment;improved;In Vitro;in vivo Model;induced pluripotent stem cell;Inflammation;Inflammatory;inhibitor;injury recovery;Injury to Kidney;insight;Interruption;Investigation;Ischemia;ischemic injury;Kidney;kidney fibrosis;kidney repair;Knockout Mice;Knowledge;Lipid Peroxidation;Lipid Peroxides;Longitudinal Studies;LoxP-flanked allele;male;Modeling;Molecular;mortality;mouse genetics;mouse model;Mus;Mutant Strains Mice;new therapeutic target;novel;novel therapeutics;Operative Surgical Procedures;Organ;Organoids;Outcome;Ovariectomy;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;pharmacologic;Pharmacology Study;Phenotype;pre-clinical;Predisposition;prevent;Process;Receptor Signaling;Recovery;Reduced Glutathione;Regulation;Regulatory Pathway;Renal function;repaired;Reperfusion Injury;Research;Residual state;resilience;Resolution;response;Risk;Rupture;sex;Sex Differences;sexual dimorphism;Stress;stress resilience;Tamoxifen;targeted treatment;Testing;Testosterone;Therapeutic Effect;Transcription Alteration;transcriptomics;Tubular formation

PROJECT_TITLE: Ferroptosis and Ferroptotic Stress in Maladaptive Renal Repair

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Hypertension;Neurodegenerative;Neurosciences;Nutrition;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: NARRATIVE The pathological process of Alzheimer's disease (AD) in the brain starts years before symptom onset thus studying at risk population such as people with diabetes mellitus and obesity and following them over longer time will help understand the development AD. The renin angiotensin system has range of biological functions, such as blood pressure regulation, and there is growing evidence about its likely involvement in the AD process, however the exact mechanism is unclear. In this proposal we will measure RAS proteins from blood in people with history of diabetes mellitus and obesity, which increases their risk for AD, who are cognitively normal at time of blood draw and evaluate whether MRI brain images and cognitive measures obtained 9-14 years after blood draw are altered by these RAS proteins.

PI_NAMEs: YASAR, SEVIL  (contact)

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: ACE2;Adult;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;Ancillary Study;Angiotensin II;ANGPT1 gene;Antiinflammatory Effect;Antioxidants;Attention;Biological Markers;Biological Process;Blood;Blood Pressure;blood pressure control;blood pressure regulation;Blood Proteins;Blood specimen;Blood Vessels;Brain;Brain imaging;brain magnetic resonance imaging;cardiovascular risk factor;Cerebrovascular Circulation;Clinical Trials;Cognition;Cognitive;cognitive function;Confounding Factors (Epidemiology);cost effective;Data;Development;Diabetes Mellitus;Disease;Dyslipidemias;effective intervention;Elderly;Enzymes;executive function;frontal lobe;Future;gray matter;Health;High Prevalence;Hippocampus;Hypertension;Image;imaging biomarker;Impaired cognition;improved;Intervention;ischemic lesion;Learning;lifestyle intervention;Magnetic Resonance Imaging;Measures;Mediating;Medication Systems;Memory;Metabolism;Middle frontal gyrus structure;Modification;Movement;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Outcome Measure;Parietal;Parietal Lobe;Participant;Pathogenesis;Pathologic;Pathologic Processes;Pathway interactions;Peptides;Peptidyl-Dipeptidase A;Persons;Phase;Play;Population;Populations at Risk;Process;processing speed;Proteins;Protocols documentation;Public Health;randomized, clinical trials;Recording of previous events;Renin-Angiotensin System;Research;Role;Sampling;Sampling Studies;Short-Term Memory;Standardization;study population;Symptoms;System;tau Proteins;Temporal Lobe;Thick;Time;treatment trial;vascular endothelial dysfunction;Vascular Endothelium;vascular risk factor;White Matter Hyperintensity

PROJECT_TITLE: Effects of the renin angiotensin system on MRI volumetric measures and cognitive function in the Alzheimer's disease process: the LookAHEAD study

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Human Genome;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE A thorough understanding of the gene regulatory network (GRN) functioning in early mammalian embryos will aid in the diagnosis and treatment of human developmental disorders, along with facilitating more effective strategies for regenerative medicine. Until recently, tools for comprehensive characterization of the early embryonic GRN were unavailable. We will combine powerful cell-based methods with new in vivo approaches to fill this void, providing insight into the first cell fate decision during embryogenesis.

PI_NAMEs: FAZZIO, THOMAS G. (contact);FUXMAN BASS, JUAN IGNACIO

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Address;apoAI regulatory protein-1;Architecture;Atlases;Binding;Binding Sites;Biological Assay;blastocyst;Cell Count;Cell Culture Techniques;cell fate specification;Cell Line;Cells;ChIP-seq;Chromatin;Chromatin Structure;Coupled;Cultured Cells;Data Set;Development;developmental disease;Developmental Gene;Diagnosis;DNA;DNA Methylation;Embryo;embryo stage 2;Embryology;Embryonic Development;embryonic stem cell;Epiblast;Epigenetic Process;epigenomics;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene regulatory network;Genes;genome-wide;Genomic approach;genomic locus;histone modification;Human;Hybrids;in vivo;in vivo evaluation;Individual;insight;Maintenance;Mammalian Cell;Maps;Measures;Mediating;Methods;Modeling;Molecular;Molecular Genetics;Mus;Names;novel strategies;Nucleic Acid Regulatory Sequences;Nucleosomes;pluripotency;Pre-implantation Embryo Development;prevent;regenerative approach;Regenerative Medicine;Regulator Genes;Regulatory Element;Reporter;RNA Interference;Role;self-renewal;Shapes;Signal Pathway;Specific qualifier value;Stem cell pluripotency;TCF7L2 gene;Testing;tool;Totipotency;Totipotent;Totipotent cell;transcription factor;transcriptome sequencing;transcriptomics;trophoblast;trophoblast stem cell;Yeasts

PROJECT_TITLE: Characterization of the gene regulatory network governing the first cell fate decision in mammalian embryonic development

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Radiation Oncology;Women's Health Research

PHR: Cervical cancers are a leading cause of death among women worldwide. Treatment by implantation of radioactivity into the tumor with MR-guidance (MR- brachytherapy) has significantly improved survival. We accelerate MR- bracytherapy with better tumor detection and real-time dose optimization during implantation.

PI_NAMEs: VISWANATHAN, AKILA  (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: Acceleration;Adopted;advanced disease;Bladder;Blood Vessels;Brachytherapy;cancer imaging;Cancer Patient;cancer recurrence;cancer site;Catheters;Cause of Death;Cervical;Cervix Uteri;Clinical;clinical implementation;Clinical Trials;cohort;Collaborations;Communities;Complex;Complication;Computer software;Consumption;curative treatments;design;Detection;Devices;Diffusion;Disease;Dose;dosimetry;Edema;Endometrial;Engineering;Environment;External Beam Radiation Therapy;Fibrosis;flexibility;Goals;Gynecologic Brachytherapy;Hospitals;Hypoxia;Image;image guided;implantation;improved;industry partner;Indwelling Catheter;Infiltration;innovation;Institutional Review Boards;interstitial;Intraoperative Radiation Therapy;Location;Magnetic Resonance;Magnetic Resonance Imaging;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Measures;Medical;metallicity;Metals;method development;Methods;mortality;MRI Scans;Normal tissue morphology;novel;Outcome;Patients;Pelvis;Perfusion;Physicians;procedure cost;Procedures;Process;product development;Proliferating;Property;Prostate;prototype;Public Health;Radiation;Radiation Dose Unit;Radiation Oncologist;Radiation Oncology;Radiation therapy;Radioactivity;radiologist;Recommendation;Rectum;Recurrence;Recurrent tumor;Research;Research Personnel;Residual Neoplasm;Rod;Roentgen Rays;Scanning;side effect;software development;Software Tools;Source;success;Survival Rate;System;Technology;Time;tissue mapping;Tissues;tool;Toxic effect;treatment planning;Tube;tumor;Universities;Vagina;Validation;Woman;women's diagnosis;Women's mortality;women's treatment;Work;X-Ray Computed Tomography

PROJECT_TITLE: Changing brachytherapy with MRI remnant-tumor segmentation and active-catheter placement


NIH_SPENDING_CATS: Hematology;Kidney Disease;Rare Diseases;Sickle Cell Disease

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Progressive chronic kidney disease (CKD), associated with intravascular hemolysis, is a steady predictor of morbidity and early mortality in sickle cell disease (SCD). This project seeks to determine that circulating heme, the hemolytic byproduct, downregulates endothelial protein C receptor (EPCR) through induction of endothelial P-selectin and neutrophilic proteinase 3 (PR3) resulting in renal microvascular endothelial damage and CKD development. The project will assess whether specific genetic variants and soluble form of EPCR are associated with the risk of CKD, and identify specific intermediate therapeutic targets to impede CKD pathogenesis in SCD.

PI_NAMEs: GHOSH, SAMIT  (contact)

PROJECT_TERMS: Abnormal Red Blood Cell;Acceleration;activated protein C receptor;Adult;Affect;age related;aged;Albuminuria;Anabolism;Anemia;Binding;Biological Markers;biomarker discovery;Blood Vessels;Bone Marrow Transplantation;Cell Adhesion Molecules;Cell membrane;Cells;Characteristics;Childhood;Chronic;Chronic Kidney Failure;Clinical;Clinical Data;cohort;Data;Deterioration;Development;Disease Progression;disorder risk;DNA;Dose;drug discovery;Endothelial Cells;endothelial dysfunction;Endothelium;epidemiology study;Event;experimental study;extracellular vesicles;Flow Cytometry;Foundations;Frequencies;genetic variant;Genotype;Glomerular Filtration Rate;Health;Heme;Hemin;Hemolysis;Histone Acetylation;Histone Deacetylase Inhibitor;Human;Impairment;In Vitro;Individual;Infusion procedures;Injections;Intravenous;Kidney;kidney vascular structure;Lead;Lysine;Measures;Microalbuminuria;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Mutant Strains Mice;neutrophil;NF-kappa B;novel marker;Organ;Organ failure;overexpression;P-Selectin;Pathogenesis;Patients;Peptide Hydrolases;Permeability;Phenocopy;PI3 gene;Pilot Projects;Plasma;Predisposition;premature;prevent;Progressive Disease;Prolastin;Prophylactic treatment;Proteinase 3;Proteins;receptor expression;Receptor Gene;Renal function;Research;Risk;Sampling;Selectins;Severities;Sickle Cell Anemia;sickling;Single Nucleotide Polymorphism;Specificity;targeted treatment;Testing;therapeutic target;Transgenic Organisms;Tube;ultra high resolution;Ultrasonography;Variant;Vascular Endothelium;Vascular Permeabilities

PROJECT_TITLE: Renal endothelium and the development of chronic kidney disease in sickle cell disorders


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Genetics;Heart Disease;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE The proposed work aims to elucidate the complex relationships between early life cardiovascular disease risk factors, epigenetic age acceleration, and midlife brain health. Knowledge gained from this study may contribute important insights into the biological pathways linking heart and brain health and provide novel strategies for the targeted prevention of epigenetic age acceleration and its brain health sequelae.

PI_NAMEs: BAZZANO, LYDIA ;CARMICHAEL, OWEN T.;KELLY, TANIKA NICOLE (contact)

PROJECT_TERMS: accelerated epigenetic aging;Adult;Affect;African American population;Age;Algorithms;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid;Articulation;Biological;biracial;Blood Pressure;Body mass index;Brain;brain health;brain magnetic resonance imaging;Cardiac health;cardiovascular disorder risk;Cerebrovascular Circulation;Cerebrum;Childhood;Chronology;Clinical;Cognition;cognitive function;cohort;Cohort Studies;Complex;Data;Dementia;DNA Methylation;DNA methylation profiling;drug development;effective therapy;follow-up;Functional Magnetic Resonance Imaging;genome-wide;global health;Glucose;gray matter;Heart;Impaired cognition;improved;individualized prevention;insight;Investments;Knowledge;Life;Life Cycle Stages;Link;Lipids;Magnetic Resonance Imaging;Measures;Mediating;middle age;Molecular;molecular drug target;Molecular Profiling;Neurobiology;neurocognitive test;neuropathology;novel;novel strategies;older adult;Participant;Pathology;Pathway interactions;Phenotype;Photons;Population;Precision Health;Predictive Factor;prevent;Prevention;Prevention strategy;prospective;Race;Renal function;Research;Resources;Risk Factors;risk stratification;Sampling;Scanning;sex;Syndrome;Testing;Therapeutic;tomography;United States National Institutes of Health;Visit;waist circumference;White Matter Hyperintensity;Work

PROJECT_TITLE: Early Life Cardiovascular Disease Risk Factors, Epigenetic Age Acceleration, and Alzheimer's Disease Related Brain Health

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Brain Disorders;Hearing Loss;Neurodegenerative;Neurosciences;Prevention;Regenerative Medicine;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Project Narrative - Public Health Relevance  Cochlear synaptopathy is the permanent damage to nerve fibers connecting the sensory cells of the inner ear to the brain, which occurs in noise-induced and age-related hearing loss well before changes in the threshold audiogram. This nerve damage is likely a major contributor to difficulties understanding speech in a noisy environment that characterize many types of sensorineural hearing impairment and may also be a key elicitor of tinnitus and hyperacusis. The research proposed here will directly address the mechanisms by which this pathology arises, how the signal-carrying capacity of the auditory nerve is compromised in this condition, and how the condition can be diagnosed non-invasively. The proposed research will also extend our work on the development of therapies for this type of neural damage. The ultimate success of these therapies holds promise to improve the hearing abilities of millions of people with sensorineural hearing loss and to eliminate the suffering produced by hyperacusis and tinnitus.

PI_NAMEs: CORFAS, GABRIEL ;LIBERMAN, M. CHARLES (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: 3-Dimensional;Acoustic Nerve;Acoustics;Address;Age;age related;Aging;Animals;Antigens;Auditory;Biological Assay;Brain;Capsid;Carrying Capacities;Cavia;cell injury;Cells;Chronic;Clinical;Cochlea;cochlear synaptopathy;Complex;Confocal Microscopy;Cytomegalovirus;Deafferentation procedure;Development;Ear;efficacy evaluation;Elements;Environment;Equilibrium;Fiber;gene therapy;Hearing;hearing impairment;hearing preservation;Hearing Tests;Human;Hyperacusis;improved;inhibitor;Injury;Inner Hair Cells;Ions;Label;Laboratories;Labyrinth;Machine Learning;Maintenance;Mediating;minimally invasive;Molecular;mouse model;Mus;Natural regeneration;nerve damage;Nerve Degeneration;Nerve Fibers;nerve supply;neural;Neurites;neurophysiology;Neurotrophic Tyrosine Kinase Receptor Type 3;Neurotrophin 3;Noise;noise exposure;Noise-Induced Hearing Loss;noninvasive diagnosis;novel;overexpression;Pathology;Performance;Persons;Pharmaceutical Preparations;Population;Population Study;Predisposition;Presbycusis;prevent;Progress Reports;promoter;Property;public health relevance;reconstruction;Recovery;Regenerative capacity;repaired;Reporting;Research;Resources;response;Risk Factors;Role;round window;Scanning Electron Microscopy;segregation;Sensorineural Hearing Loss;Sensory;Shapes;Signal Transduction;species difference;Speech;speech in noise;Stimulus;success;Synapses;Synaptic Transmission;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapy development;Tinnitus;Transgenic Organisms;translational approach;Up-Regulation;Viral;virtual;Work

PROJECT_TITLE: Cochlear synaptopathy in noise-induced and age-related hearing loss: mechanisms and treatments

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE The Basic Immunology Training Program will teach the next generation of US researchers the critical skills they will need to perform outstanding basic immunologic research. Future discoveries by these researchers will be absolutely essential for our continued progress in the fights against infectious diseases, cancer, autoimmune diseases, and immunodeficiency diseases.

PI_NAMEs: KRANGEL, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Immunology;Training Programs

PROJECT_TITLE: Basic Immunology Training Program

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE All of the brain’s functions, even basic functions like processing sensory information, are powerfully shaped by experience-driven synaptic plasticity and learning. Experience-dependent changes in the timing rules governing synaptic plasticity could support improvements in the temporal accuracy of learning, whereas improper tuning of the timing rules for plasticity could corrupt the learning process and contribute to an array of neurological disorders.

PI_NAMEs: RAYMOND, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Adult;Algorithms;Behavior;behavior observation;Behavioral;Brain;Calcium;Cerebellum;Clinical;Compensation;dark rearing;Development;differential expression;Dimensions;Environment;Event;Evolution;experience;experimental study;Eye Movements;Feedback;Fiber;Funding;Gene Expression Profiling;Genes;Housing;Image;improved;In Vitro;in vivo;Learning;Life;Life Experience;Link;Long-Term Depression;Measures;Modeling;Molecular;motor learning;Mus;Nervous System Disorder;neural;neural circuit;neuromechanism;Neurosciences;novel;oculomotor;Performance;Physiology;Process;Purkinje Cells;Reporting;Research;response;Role;Sensory;Shapes;Signal Transduction;Structure of purkinje fibers;Synapses;Synaptic plasticity;System;Testing;Time;translating ribosome affinity purification and RNA-sequencing;Visual;visual feedback;Work

PROJECT_TITLE: Instructive Signals for Motor Learning

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Aging;Genetics;Kidney Disease

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative Acute kidney injury leads to acute loss of kidney function that may progress to the point of needing dialysis treatment (the artificial kidney) and may also lead to chronic kidney disease and endstage kidney disease. Older age is a major risk factor for acute kidney injury and there is evidence that a certain type of aged cells (senescent cells) can cause kidney disease. This grant application will test the involvement of these cells in acute kidney injury and determine whether a new therapy (called senolytics) that destroys these cells will protect against acute kidney injury.

PI_NAMEs: NATH, KARL A. (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;age-related disease;Apoptosis;Apoptotic;Applications Grants;Area;Artificial Kidney;Attention;Automobile Driving;CDKN2A gene;cell age;Cell Cycle;Cell Cycle Arrest;Cell Proliferation;Cell Survival;Cells;Cellular Stress;Chronic Kidney Failure;Clinical Trials;clinically relevant;cytokine;Cytoprotection;Dasatinib;Data;Dialysis procedure;Disease;Distant;DNA Damage;efficacy evaluation;End stage renal failure;Endocrine;Epithelial Cells;ETS1 gene;Excision;Exhibits;exposed human population;Exposure to;Family;fisetin;Genetic;genetic approach;Geroscience;Glycerol;Heme;Hemeproteins;Hour;human old age (65+);Impairment;In Vitro;in vitro Model;in vivo;in vivo Model;indexing;Induction of Apoptosis;Inflammatory;inhibitor;injured;Injury;insight;Kidney;Kidney Diseases;Knockout Mice;Lamin B1;Link;lipophilicity;LOX gene;Mediating;Metabolic;Mitochondria;mitochondrial dysfunction;Modeling;Mus;novel;novel therapeutic intervention;novel therapeutics;old mice;Organelles;paracrine;Pathogenesis;Pathway interactions;pharmacologic;Phenotype;Phosphoenolpyruvate Carboxylase;Proteins;Proximal Kidney Tubules;Publishing;Quercetin;Reactive Oxygen Species;recruit;Reducing Agents;Renal function;renal ischemia;Reperfusion Injury;Resistance;Respiration;response;Risk Factors;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Stains;telomere;Testing;Tetrapyrroles;Therapeutic;tissue stress;Tissues;transcription factor;Tubular formation;Up-Regulation

PROJECT_TITLE: Heme-mediated Mitochondrial Injury, Senescence, Acute Kidney Injury and Chronic Kidney Disease


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;HIV/AIDS;Infectious Diseases;Mental Health;Mental Illness;Microbiome;Natural Products;Neurosciences

ORG_DEPT: PSYCHIATRY

PHR: Narrative Depression remains among the most refractory psychiatric comorbidities in people living with human immunodeficiency virus despite the universal use and success of combination antiretroviral therapy. Nonetheless, lack of pathophysiological mechanisms underlying this comorbidity hampers advances in its prevention and treatment. In this study, we aim to identify aberrant gut bacterial-fungal interactions-mediated inflammatory mechanisms underlying HIV-induced depressive-like behaviors in EcoHIV mouse model, and also explore the novel mechanisms whereby pachyman may normalize HIV infection-induced gut microbiota dysbiosis, inhibit sustained inflammation, and provide antidepressant effect via inhibition of dectin-1 signaling.

PI_NAMEs: ZHU, XIAOLEI  (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: 3-Dimensional;Animals;antidepressant effect;antiretroviral therapy;Attention;Bacteria;Basic Science;Behavior;behavior test;behavioral phenotyping;beta-Glucans;Biological;Biological Assay;biomarker selection;Blood;Brain region;Butyrates;Central Nervous System;Characteristics;Chinese Traditional Medicine;Circulation;Clinical;Clostridium;Cocos;Collaborations;Communities;comorbidity;Data;Data Set;dectin 1;depressive symptoms;Disease Progression;drug development;dysbiosis;Epidemiology;Fatty Liver;Feces;forced swim test;Functional disorder;Funding;fungus;General Population;Genetic;Genetic Transcription;Goals;gut bacteria;gut inflammation;gut microbiota;High Pressure Liquid Chromatography;High Prevalence;HIV;HIV Infections;Immune;Impairment;Infection;Inflammation;Inflammatory;inflammatory marker;Knowledge;Laboratory Research;Lactobacillus;Limulus;Major Depressive Disorder;Mediating;Medicinal Herbs;Mental Depression;Mentors;metagenomic sequencing;microbial;mouse model;Mus;Myeloid Cells;Natural Products;Nature;neuroinflammation;neuropsychiatric disorder;novel;Obese Mice;Pathologic;Pathway interactions;Patients;Pattern Recognition;Persons;Phagocytes;Pharmacology;Phenotype;Play;polyglucosan;Poria;preclinical study;preference;Prevention;product development;protective effect;psychiatric comorbidity;receptor;Refractory;Research;Research Methodology;Rodent Model;Role;Signal Transduction;skills training;social;Social Behavior;Social Interaction;Sodium Dextran Sulfate;Step training;success;Sucrose;systemic inflammatory response;Testing;Time;Training;translational therapeutics;treatment effect;Virus Diseases;Virus Replication;Volatile Fatty Acids

PROJECT_TITLE: Exploring a natural product to modulate aberrant gut bacterial-fungal interactions as pathological mechanisms underlying HIV-associated depression


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Primary Health Care;Social Determinants of Health;Suicide;Suicide Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Violence Research

PHR: Veterans have a high rate of suicide, but prevention efforts have focused mostly on veterans who use Veteran Health Administration (VHA) healthcare. This project will assemble and analyze health records from civilian, non-VHA healthcare systems to find veterans who are at the greatest risk. This work lays a foundation for healthcare-based suicide prevention among an understudied group at very high risk of suicide.

PI_NAMEs: KIMBREL, NATHAN A.;SWANSON, JEFFREY W (contact)

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Accounting;Address;Administrator;Adult;Algorithms;Behavior;Bioethics Consultants;Caring;Cessation of life;Characteristics;Clinical;Clinical Protocols;combat;Data;Data Element;Data Sources;Databases;Death Records;Department of Defense;diagnostic signature;Electronic Health Record;Elements;encryption;Environment;Environmental Risk Factor;Epidemic;Equity;Ethics;Firearms;Foundations;Future;Goals;Health;health care service;health care service utilization;health record;Health Services;Health Services Administration;Health system;Healthcare;Healthcare Systems;high risk;high risk population;improved;Incidence;Individual;informant;Informatics;Infrastructure;Intervention;Interview;Knowledge;Link;Literature;longitudinal database;Machine Learning;machine learning method;Medical;Medical Records;Mental Health;Methods;military patient;Military Personnel;military veteran;mortality;multidisciplinary;Nature;North Carolina;novel;Outcome;patient health information;patient population;Patients;Pattern;Persons;Play;Population;prediction algorithm;Prevention;Preventive care;Primary Care;privacy protection;Private Sector;prospective;Protocols documentation;Provider;psychologic;Recording of previous events;Records;reducing suicide;Research;Research Personnel;research study;Risk;Risk Factors;risk prediction model;Role;Secure;Series;service member;service utilization;Services;Severities;social;Structure;Substance Use Disorder;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide prevention;suicide rate;Survival Analysis;System;targeted delivery;Training;Traumatic Brain Injury;trend;United States Department of Veterans Affairs;Utah;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Predicting firearm suicide in military veterans outside the VA health system using linked civilian electronic health record data

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE G protein signaling pathways play an essential role in normal human physiology and are disrupted in a wide range of pathological conditions. Studies proposed herein are aimed at understanding molecular mechanisms controlling the function of the neuronal G protein signaling pathways that are involved in mood regulation. It is anticipated that the results will facilitate the design of novel strategies for the treatment of depression and anxiety and possibly other neuropsychiatriac conditions.

PI_NAMEs: MARTEMYANOV, KIRILL A. (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Ablation;Address;Affect;Affective;Alleles;Animal Model;anti-depressive agents;Anxiety;Attention;Autopsy;Behavior;Behavioral;Binding;Biochemical;Biochemistry;Biological;Biology;Brain;Brain Diseases;Cell Adhesion;Cell membrane;Cells;Cellular Assay;Complex;Consensus;Corpus striatum structure;Cyclic AMP;Darkness;Data;design;Development;Diagnosis;Disease;Dissection;drug development;Electrophysiology (science);Elements;Event;extracellular;Extracellular Matrix;Family;FDA approved;frontier;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein Signaling Pathway;G-Protein-Coupled Receptors;Generations;genetic manipulation;Glucocorticoids;Goals;Grant;GTP-Binding Protein Regulators;GTP-Binding Proteins;Heparan Sulfate Proteoglycan;Hormones;Human;innovation;insight;interest;Ion Channel;Knockout Mice;Kv4.2 channel;Label;Lead;Learning;Ligands;Major Depressive Disorder;Mammals;Mediating;Mediator;member;Memory;Mental Depression;Molecular;mood regulation;Moods;Mus;Nervous System;Nervous System Physiology;Neurologic;neuronal circuitry;neuronal excitability;Neurons;neuropsychiatry;neuroregulation;neurotransmission;Neurotransmitter Receptor;Neurotransmitters;novel;novel strategies;optical sensor;Orphan;Osteocalcin;overexpression;Pathologic;Pathway interactions;Patients;Peptides;Perception;Pharmaceutical Preparations;Pharmacology;Phenotype;Physiology;Play;Population;Potassium Channel;Process;Production;Proteins;Proteolytic Processing;Proteomics;Reaction;receptor;recruit;Regulation;Reporter;Reporting;Research;Role;Second Messenger Systems;Sensory;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Signaling Protein;Stress;stress resilience;success;Synaptic Transmission;Technology;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;trafficking;trait;transmission process;treatment strategy

PROJECT_TITLE: Orphan Receptors in Regulation of Neuronal G Protein Signaling

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: 8 – Project Narrative Driven by changes in the microbial community that colonizes the gingiva next to the tooth, periodontitis is a chronic inflammatory condition characterized by the destruction of the connection between the teeth and the bone that supports them. We have been studying an antimicrobial protein produced by gingival epithelial cells and neutrophils, and have shown that this protein, named calprotectin, causes suppression of the early inflammatory response around teeth when the disease begins. We now seek to understand why.

PI_NAMEs: COSTALONGA, MASSIMO  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Acute;Adult;Affect;alveolar bone;alveolar destruction;Animals;antimicrobial;Binding;bone;Cell Shape;Cells;Cellular Infiltrate;Characteristics;Chronic;Chronic Phase;Complex;Data;design;Disease;Divalent Cations;dysbiosis;Economics;Environment;Epithelial Cells;Etiology;Excision;fascinate;Functional disorder;Gingiva;Human;Immune;Immune response;Immunosuppression;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Infiltrate;Inflammatory Response;Innate Immune Response;intraepithelial;keratinocyte;Knockout Mice;Leukocyte L1 Antigen Complex;Ligands;Ligature;Mediating;Microbial Biofilms;microbial community;Modeling;mouse model;Names;neutrophil;novel;pathobiont;Periodontal Diseases;Periodontitis;Periodontium;Phase;Porphyromonas gingivalis;Proteins;Recovery;recruit;Regulatory T-Lymphocyte;Reporting;Resolution;Role;S100A8 gene;S100A9 gene;Signal Transduction;Stratified Squamous Epithelium;Structure of gingival sulcus;targeted treatment;Testing;Therapeutic Intervention;Tissues;tool;Tooth Loss;Tooth structure

PROJECT_TITLE: Calprotectin-mediated CD69 signaling in periodontitis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Narrative Angiogenesis is an important biological process essential for tissue repair following injury or disease. In this project we will use a tissue-engineered model of brain microvessels to establish the role of pericytes during angiogenesis. Elucidating the mechanisms of angiogenesis in the brain will enable the development of new therapies for cerebrovascular repair.

PI_NAMEs: SEARSON, PETER C (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adult;Altitude;angiogenesis;Angiogenic Factor;Animal Model;Back;Biological Assay;Biological Process;Blood - brain barrier anatomy;Blood capillaries;Blood Vessels;Brain;brain pericytes;Cell Therapy;Cells;Central Nervous System;cerebral microvasculature;cerebrovascular;Cerebrovascular system;Complex;Cues;Development;Disease;Endothelial Cells;Endothelium;Engineering;Exercise;experimental study;Exposure to;FGF2 gene;Fluorescent in Situ Hybridization;Foundations;Genes;Genetic Engineering;Goals;Growth;Growth Factor;Human;human model;Hypoxia;In Situ;Injury;Knowledge;Lead;Malignant neoplasm of brain;migration;Modeling;Mus;Neurodegenerative Disorders;Neurons;novel therapeutics;Pathologic;Pathologic Processes;Pericytes;Phase;Phenotype;Physiological;Physiological Processes;Play;postcapillary venule;Process;repaired;Reporting;response;response to injury;Retina;RNA;Role;stem cell technology;Stroke;Testing;therapy design;Tissue Engineering;tissue repair;transcriptome sequencing;transcriptomics;Trauma;Traumatic Brain Injury;Vascularization;venule;wound healing

PROJECT_TITLE: Elucidating the role of pericytes in angiogenesis in the brain using a tissue-engineered microvessel model

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Aging;Autoimmune Disease;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Sjogren’s syndrome is an autoimmune disorder responsible for causing severe dry mouth and dry eye. This proposal will investigate the reasons behind the observation that most patients diagnosed with Sjogren’s syndrome are older individuals. The project will focus on the role of aging-associated oxidative stress on salivary gland disease.

PI_NAMEs: DESHMUKH, UMESH S (contact)

PROJECT_TERMS: Address;Affect;Age;Aging;aging related;Animal Model;Antibodies;Appearance;Autoantibodies;Autoantigens;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;Big Data;Biological Models;Body System;cell injury;Cells;Chronic;Circulation;Clinical;Color;Complement;Complex;Conjunctival Epithelium;Country;Data;Development;Diagnosis;digital;Disease;Disproportionately impacts women;Dryness;Ductal Epithelial Cell;Enzymes;Epithelial Cells;expectation;eye dryness;Flow Cytometry;Fluids and Secretions;Free Radicals;Frequencies;Functional disorder;Genetic;Genetic Predisposition to Disease;Gland;Goals;human old age (65+);Hyperactivity;Immune;Immune response;Immune system;in vivo;Inflammatory Response;Injury;innovation;Knockout Mice;Lacrimal gland structure;Link;Literature;Location;Macrophage;Mediating;Mitochondria;Modality;Modeling;mouse model;Mus;novel;novel therapeutic intervention;older patient;Older Population;Oral;Organ;Outcome;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;Patients;Phenotype;Population;Predisposition;Process;Production;Proteomics;Publishing;Recovery;reduce symptoms;Reporting;Respiration;Risk Factors;Role;Saliva;Salivary Gland Diseases;Salivary Glands;sex;Sialadenitis;Sjogren's Syndrome;SOD2 gene;Superoxides;symptom treatment;Symptoms;systemic autoimmune disease;Testing;Tissues;tool;trait;Work;Xerostomia

PROJECT_TITLE: Aging and Oxidative Stress Influence Salivary Gland Disease in Sjogren's Syndrome


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: NARRATIVE Homology-directed DNA repair (HDR) removes deleterious DNA lesions that are the result of exposure to environmental and chemotherapeutic agents, and defects therein lead to genomic instability, cancer, and other diseases. We will delineate the novel mechanisms by which the opposing actions of HDR factors and regulators help determine the timing and overall efficiency of HDR. Our findings will provide actionable information to identify predictive biomarkers of cancer drug response, and to help guide the development of targeted therapies to treat HDR-deficient cancers.

PI_NAMEs: SUNG, PATRICK  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Amino Acids;Antineoplastic Agents;Attenuated;Award;BARD1 gene;Biochemical;Biochemistry;Biological;BRCA deficient;BRCA1 gene;cancer therapy;Cell Cycle;Cell Cycle Progression;Cell Death;Cells;Cellular biology;chemotherapeutic agent;Chromatin;Chromosomal Breaks;Chromosomes;combinatorial;Complex;Defect;Deoxyribonucleases;Development;Disease;DNA;DNA Binding;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Repair;DNA Repair Pathway;DNA replication fork;Double Strand Break Repair;Drug resistance;endonuclease;Environment;Enzymes;Epigenetic Process;Excision;EXO1 gene;Exposure to;Failure;Filament;Foundations;Functional disorder;G1 Phase;G2 Phase;Genetic;Genomic Instability;Goals;Grant;helicase;Human;in vivo;inhibitor;insight;Lead;Length;Link;Malignant Neoplasms;Mediating;mutant;Neoplastic Cell Transformation;Nonhomologous DNA End Joining;novel;Outcome;p53-binding protein 1;Pathway interactions;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;predictive marker;Procedures;Process;protein complex;protein purification;Proteins;Rad51 recombinase;Reader;reconstitution;recruit;Regulation;repaired;Resected;Resistance;response;restoration;Ribose;S phase;Saccharomyces cerevisiae;Saccharomycetales;Single-Stranded DNA;spleen exonuclease;System;Tail;targeted cancer therapy;targeted treatment;Testing;Therapeutic;tool;treatment response;tumor;Tumor Suppressor Proteins

PROJECT_TITLE: Mechanisms of DNA Double-strand Break End Resection and Repair Pathway Choice

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Autism;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: SAN DIEGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Project Narrative This project aims to leverage the large quantity of diffusion MRI datasets from shared ASD databases, such as the National Database for Autism Research (NDAR) and Autism Brain Imaging Data Exchange (ABIDE), as well as from normative databases (e.g., the Human Connectome Project and Adolescent Brain Cognitive Development study), to 1) create a curated resource of diffusion MRI datasets in ASD and typically developing individuals, and 2) study cross-sectional lifespan trajectories of white matter tracts in ASD, at the group and individual levels (relative to typical development). Insight gained from this project may inform policy and treatment development for lifelong support of ASD. The dMRI data resource will also help promote reproducible diffusion MRI research.

PI_NAMEs: HAU, JANICE  (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;Adult;Affect;Age;age effect;age group;aged;Aging;Anisotropy;autism spectrum disorder;autism symptoms;Behavioral;Brain;Brain imaging;Childhood;Cognitive;cognitive ability;cognitive development;Communities;connectome;Corpus Callosum;Cross-Sectional Studies;Data;data archive;data exchange;data harmonization;data resource;Data Set;Databases;Development;Diagnostic;Diffusion Magnetic Resonance Imaging;dimension reduction;early childhood;experience;Functional disorder;Growth;Human;Image;improved;in vivo;indexing;Individual;individuals with autism spectrum disorder;insight;Joints;Knowledge;Life;life span;Link;Location;Maps;Measures;Methodology;Methods;Modeling;multimodality;National Institute of Mental Health;neural;neural circuit;Neural Pathways;Neuroanatomy;neurodevelopment;neuroimaging;Outcome;Participant;Pattern;Policy Developments;Process;Protocols documentation;Quality Control;rate of change;Reproducibility;Research;Resource Sharing;Resources;Sample Size;Sampling;Scanning;Sequence Analysis;Severities;sex;shared database;Site;social;social communication impairment;spatiotemporal;Specificity;Standardization;Structure;Symptoms;Techniques;thalamocortical tract;therapy development;Time;Uncertainty;white matter;Work

PROJECT_TITLE: Mapping lifespan trajectories of white matter in autism and improving reproducibility through shared diffusion MRI data

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Neurosciences;Tobacco

ORG_CITY: CHAMPAIGN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Neonicotinoids are commonly used pesticides and humans are exposed to them daily through food, water, and soil. The proposed research will determine the mechanisms by which prenatal and adult exposure to a neonicotinoid can causes deficits in learning and memory systems in mammals. Identifying how neonicotinoids can act on memory centers in the brain is relevant to public health since it will enable us to improve strategies for prevention or reduction of risks following exposures.

PI_NAMEs: MAHONEY, MEGAN M (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Acetylcholine;Acute;Address;Adult;Aerosols;Affect;Affinity;Agriculture;alpha-bungarotoxin receptor;Animals;anxiety-like behavior;Behavior;behavior test;Binding;Blood;Brain;Categories;Cells;Child;Chronic;Cognition;cognitive function;Compensation;Consumption;Corpus striatum structure;Country;desensitization;Development;Dose;drinking water;Dust;Environment;exposed human population;Exposure to;Female;Fiber;Food;Hair;Hippocampus;Human;Human Milk;imidacloprid;Immune;Impairment;improved;in utero;Inflammation;Insecta;Insecticides;Invertebrates;Learning;male;Mammals;mature animal;Measures;Mediating;Memory;Metabolic;Modeling;Motor;mRNA Expression;Mus;Mutagenesis;Nervous System;neural;neurogenesis;neurophysiology;Neurophysiology - biologic function;neurotransmitter release;Nicotine;nicotine exposure;Nicotinic Agonists;Nicotinic Receptors;North America;novel;Oxidative Stress;Performance;Pesticides;Photometry;Physiological Processes;Plants;Population;Pregnancy;pregnant;prenatal;Prevention strategy;procedural memory;protein expression;Proteins;Public Health;receptor;receptor binding;receptor expression;receptor function;Receptor Up-Regulation;receptor upregulation;reproductive;Research;response;Rewards;Risk;Rodent;Safety;Saliva;Sampling;sensor;Sex Differences;Short-Term Memory;Signal Pathway;Soil;spatial memory;Structure;Synaptic plasticity;System;Testing;trait;Transcript;Urine;Vertebrates;Virus;Water

PROJECT_TITLE: The impact of a neonicotinoid pesticide on neural functions underlying learning and memory

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: Project Narrative Hematopoietic stem cells (HSC) are blood-forming stem cells that support life-long blood production and can restore all blood lineages when transplanted into patients suffering from hematologic disease. Sickle Cell Disease (SCD) is an inherited blood disorder that effects thousands of patients in the United States and damages HSCs, although this has yet to be deeply explored. To illuminate opportunities to restore function to HSCs in individuals with SCD, here we will investigate their function and molecular programs in both mouse models and patients with SCD.

PI_NAMEs: MCKINNEY-FREEMAN, SHANNON L (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Age;Age Months;Age of Onset;Allogenic;AMD3100;Antibodies;Apoptosis;Autologous;beta-Galactosidase;Biological Assay;Biological Markers;Blood;Bone Marrow;Bone Marrow Transplantation;Bromodeoxyuridine;CD34 gene;cell age;Cell Aging;Cell Cycle;Cell Separation;Cell Size;Cell surface;Cells;Cellular Assay;Childhood;Chronic;curative treatments;Data;DNA Damage;exhaust;experience;fitness;Functional disorder;functional restoration;Gene Expression;Gene Expression Profiling;gene therapy;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Heme;Hemolysis;Hemolytic Anemia;Hemopexin;Human;hydroxyurea;Immune;Impairment;in vivo;Individual;Inflammation;Inflammatory;Inherited;inhibitor;leukemia;Microscopy;middle age;Molecular;Molecular Disease;mouse model;multiorgan damage;Mus;Mutation;Output;Pathologic;Patients;peripheral blood;Pharmaceutical Preparations;Phenotype;Physiologic pulse;Physiological;Pilot Projects;Population;premature;prevent;Production;progenitor;programs;reconstitution;Refractory;repaired;Resolution;RNA;Sampling;self-renewal;senescence;senescent cell;Sickle Cell Anemia;Stains;stem;stem cell function;stem cell gene therapy;Stress;Stress Tests;Supporting Cell;telomere;Testing;Time;TP53 gene;transcriptome sequencing;transcriptomics;Transplantation;United States;uptake;vaso-occlusive pain;Xenograft procedure

PROJECT_TITLE: Investigating hematopoietic stem cell dysfunction during sickle cell disease


NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Genetic Testing;Genetics;Infectious Diseases;Lung;Prevention;Rare Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE In the United States there are approximately 10-15 million carriers of gene mutations that cause cystic fibrosis (CF), an autosomal recessive disease. Although having one defective copy of this gene was not thought to be related to poor health outcomes, CF carriers in small studies, and in our own preliminary work, appear to be at higher risk for respiratory infections. We propose to determine the risk for respiratory infections attributable to the CF carrier state and to investigate the potential future feasibility of preventing or treating respiratory infections in CF carriers using currently existing medications.

PI_NAMEs: POLGREEN, PHILIP M. (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Address;Affect;African American population;Age;airway epithelium;antimicrobial;Area;Aspergillosis;Asthma;attributable risk;autosome;Bicarbonates;Biological;Biological Assay;Bronchiectasis;Bronchitis;Carrier State;Caucasians;Cell Culture Techniques;Characteristics;Chlorides;Clinical Data;Code;cohort;Communicable Diseases;comparison control;Computerized Medical Record;cost effective treatment;Cystic Fibrosis;cystic fibrosis infection;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Data Set;design;Diabetes Mellitus;Diagnosis;Disease;disorder risk;DNA Sequence Alteration;electronic data;Epidemiology;Epithelial Cells;Epithelium;Frequencies;Future;Gastrointestinal Diseases;Gene Mutation;General Population;Genes;Genetic Counseling;Genetic Diseases;genetic testing;Genotype;Goals;Health;Heterozygote;high risk;Hospitalization;Human;Individual;Infection;injured airway;innovation;Intervention;Investigation;Length of Stay;Longitudinal cohort;Medical Records;Methods;Mission;Modeling;Morbidity - disease rate;mortality;Mutation;Mycobacterium Infections;National Institute of Allergy and Infectious Disease;Natural History;Pancreatitis;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pneumonia;poor health outcome;Population;population based;prevent;Procedures;readmission rates;recessive genetic trait;Recurrence;recurrent infection;Regulator Genes;Research;respiratory;Respiratory Tract Infections;Risk;Risk Estimate;Role;Severities;sex;Sinusitis;Surface;Testing;United States;Work

PROJECT_TITLE: Estimating the risk for and severity of respiratory infections attributable to CFTR heterozygosity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Children with congenital vestibular disorders (CVDs) experience delayed motor development and challenges in maintaining posture and balance that never achieve normal adult levels. The proposed experiments involve surgical manipulation of the developing chick inner ear to generate a highly reproducible, sac-like inner ear that resembles the most common malformation found in children with CVDs, followed by experiments to determine how the sac-like inner ear pathology alters connectivity in the peripheral and central vestibular system. The goal of this research is to provide basic science understanding of the mechanisms underlying CVDs that can support devising new approaches to treat causes rather than the symptoms of CVDs and improve the quality of life for CVD children.

PI_NAMEs: PEUSNER, KENNA D (contact)

PROJECT_TERMS: Address;Adult;Affect;Age;Animal Model;Animals;Anterior;Aromatase;Auditory;base;Basic Science;biocytin;Birds;Brain;Brain Stem;Cell Count;Cell Nucleus;Cells;Chick;Chick Embryo;Chick model;Child;Childhood;Clinic;Clinical;Clinical assessments;Congenital Abnormality;Data;Development;Developmental Delay Disorders;disability;Disease;Dizziness;Electrophysiology (science);Embryo;Equilibrium;Ethology;experience;experimental study;Fiber;Foundations;Functional disorder;ganglion cell;Goals;Hair Cells;hatching;Image;improved;inner ear development;Label;Laboratories;Labyrinth;Life;Link;malformation;Membrane;Modeling;Motor;neural circuit;Neurons;Neurotransmitters;new therapeutic target;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Organ;otoconia;Outcome;patch clamp;Pathologic;Pathology;Patients;Pattern;Peripheral;Phenotype;Physical therapy;Planet Earth;Posture;Pregnancy;Procedures;Property;Quality of life;Reflex action;Reporting;Reproducibility;Research;ribbon synapse;Role;Rotation;Semicircular canal structure;Sensory;Side;signal processing;Signal Transduction;Site;Stains;Structure;Symptoms;Synapses;Synaptic Transmission;Testing;Thinking;Time;Tissue Stains;Tissues;Vestibular Diseases;Vestibular dysfunction;Vestibular epithelia;Vestibular function;Vestibular ganglion;Vestibular Nerve;Vestibular nucleus structure;vestibular pathway;vestibular reflex;vestibular system;vestibulo-ocular reflex;visual tracking;Walking;Work;X-Ray Computed Tomography

PROJECT_TITLE: The Peripheral Vestibular System in Congenital Vestibular Disorders


NIH_SPENDING_CATS: Endocrine Disruptors;Genetics

ORG_CITY: WOODS HOLE

ORG_NAME: WOODS HOLE OCEANOGRAPHIC INSTITUTION

PHR: Project Narrative The aryl hydrocarbon receptor (AHR) mediates the toxicity of dioxin-like environmental contaminants and has been implicated in the etiology and progression of inflammatory diseases and cancer, but a comprehensive, mechanistic understanding of how chemicals cause toxicity via the AHR has been hindered by the complexity of its physiological functions and the diversity of its ligands (AHR promiscuity). The proposed research will reveal the properties of the primordial ligand-activated AHR and the molecular mechanisms underlying the evolution of promiscuity. This basic research will provide fundamental new insights into the natural physiological ligands and biological functions of the AHR, reveal the genetic and structural mechanisms underlying AHR ligand recognition, and elucidate how and why AHR function is disrupted by exposure to anthropogenic environmental contaminants.

PI_NAMEs: HAHN, MARK E (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Address;Agonist;Allosteric Regulation;Amino Acid Sequence;Amino Acids;Animals;anthropogenesis;Aromatic Hydrocarbons;Aromatic Polycyclic Hydrocarbons;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Basic Science;Binding;Biological Process;candidate identification;Cell Differentiation process;Chemicals;Chordata;Circadian Rhythms;Dependence;Development;Dietary Phytochemical;Dioxins;Disease;Docking;Embryonic Development;Engineering;Environmental Exposure;Environmental Pollutants;Enzymes;Etiology;Eukaryota;Evolution;exposed human population;Exposure to;Family;Foundations;Genetic;Goals;gut microbiome;halogenation;Helix-Turn-Helix Motifs;Hematopoiesis;host microbiome;Hypoxia Inducible Factor;immune function;Immunity;Inflammatory;innovation;insight;Invertebrates;Laboratories;Ligand Binding;Ligands;Malignant Neoplasms;Mediating;member;microbial;microbiome;Modernization;Molecular;molecular modeling;Mutate;Mutation;Natural Products;NPAS4 gene;Nuclear Receptors;Organ;Phylogenetic Analysis;Physiological;Physiological Processes;Physiology;Play;Polychlorinated Biphenyls;Process;Property;Proteins;receptor;receptor function;reconstruction;Regulation;Research;response;Role;Sampling;Sensitivity and Specificity;sensor;Signal Transduction;single-minded protein;Specificity;Statistical Methods;Structure;Testing;Tetrachlorodibenzodioxin;Time;Toxic effect;transcription factor;Transcriptional Activation;Trees;Tryptophan;Vertebrates;Work;Xenobiotics

PROJECT_TITLE: Understanding the origins and mechanisms of aryl hydrocarbon receptor promiscuity

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Gene Therapy;Genetics;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The complexity human facial development means that it is vulnerable to environmental and genetic perturbations, such that craniofacial malformations are one of the most common classes of birth defects, occurring in ~1.5 in 1000 newborns. The presence of an orofacial cleft requires multiple operations to correct the defect and this frequently reduces the quality of life for both the child and the parents and imposes a significant psychological and economic burden on families. Here, we are using mutant mouse models that mimic a genetic cause of human orofacial clefting to test if in utero treatments can prevent such clefts from occurring during fetal development and so alleviate the need for later post-natal treatment and surgery.

PI_NAMEs: LI, HONG ;WILLIAMS, TREVOR J (contact)

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: Acceleration;Adenine;adeno-associated viral vector;Affect;Alleles;Animal Model;Antisense Oligonucleotides;base editor;Binding;Biological Models;Branchio-Oculo-Facial Syndromes;Cells;Child;cleft lip and palate;Cleft lip with or without cleft palate;Clinical Research;Complex;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;craniofacial development;craniofacial disorder;Defect;Dental;Development;Developmental Process;dimer;Disease;DNA;DNA Binding;DNA Double Strand Break;DNA Repair;Dominant-Negative Mutation;Economic Burden;Embryo;Etiology;Eye;Face;family burden;Fetal Development;Frequencies;gene editing technology;Gene Mutation;gene therapy;gene-editing approach;Genes;Genetic;Genetic Processes;Genome;Head;hearing impairment;Heterozygote;Human;Human Pathology;humanized mouse;in utero;In Vitro;in vivo;Individual;infancy;Inherited;Injections;knock-down;Link;Live Birth;Long-Term Effects;loss of function mutation;Lung;Mental Health;Missense Mutation;Modality;Modeling;Morphogenesis;mouse model;mRNA Stability;Mus;mutant;mutant mouse model;Mutate;Mutation;National Institute of Dental and Craniofacial Research;Newborn Infant;off-target mutation;operation;Operative Surgical Procedures;oral tissue;orofacial;orofacial cleft;Outcome;Parents;Patients;Phenotype;physical conditioning;Positioning Attribute;postnatal;precision medicine;prevent;Process;Proliferating;Proteins;psychologic;Quality of life;repaired;Research;Research Support;response;RNA Splicing;Site;Skin;Structural Congenital Anomalies;System;Technology;Testing;TFAP2A gene;Therapeutic;Titrations;Tooth Diseases;Transcript;transcription factor;Viral Vector

PROJECT_TITLE: In utero rescue of cleft lip and palate in a humanized mouse model


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Infectious Diseases;Lung;Osteoporosis;Rare Diseases;Social Determinants of Health;Tuberculosis

ORG_CITY: ULAANBAATAR

ORG_COUNTRY: MONGOLIA

ORG_FIPS: MG

ORG_NAME: MONGOLIAN NATIONAL UNIV/MEDICAL SCIENCES

PHR: PROJECT NARRATIVE  This project uses a multidisciplinary approach, integrating epidemiologic observational studies and laboratory cell-model toxicology experiments, to investigate whether and how particulate matter air pollution affect respiratory viral infections. Ancillary pilot study projects will explore the impact of particulate pollution on pulmonary tuberculosis and osteoporosis. Mongolia has high prevalence and incidence of these diseases and high particulate matter levels in the world.

PI_NAMEs: DAMBADARJAA, DAVAALKHAM - (contact);GRAY, GREGORY CHARLES;ZHANG, JUNFENG

PROGRAM_OFFICER_NAME: JESSUP, CHRISTINE

PROJECT_TERMS: Address;Adult;Affect;Age;Air;Air Pollution;air pollution control;airway epithelium;Anti-Inflammatory Agents;Anti-viral Response;Attention;Back;Bacterial Infections;Biological Markers;Biometry;bone;Cell Culture Techniques;Cell model;Cells;Cessation of life;Cities;Coal;coarse particles;Communicable Diseases;COVID-19 impact;COVID-19 pandemic;cytokine;Data;design;Diameter;Disease;Economics;environmental change;Environmental Engineering technology;Environmental Health;Epidemiology;epidemiology study;Epithelium;experience;experimental study;Exposure to;Faculty;fine particles;flu;follow-up;Government;Heating;Heavy Metals;High Prevalence;Human;Immune;Immune response;Immune signaling;Immunologic Markers;Immunologics;Immunology;Impairment;improved;Incidence;Infection;Inflammatory;Inflammatory Response;Influenza;insight;Institution;interdisciplinary approach;Interdisciplinary Study;Interferon Type I;Intervention;Laboratories;Length;Ligands;Link;Liquid substance;Literature;Longitudinal trends;Measures;Medical;Medicine;member;Mentors;meter;Minerals;Mongolia;Morbidity - disease rate;mortality;non-smoking;Nose;Observational epidemiology;Observational Study;Occupational Health;Osteoporosis;Oxidative Stress;Ozone;Participant;Particulate;Particulate Matter;Pilot Projects;Policies;pollutant;Pollution;Population;Predisposition;premature;Process;programs;Protocols documentation;Public Health;Publishing;Pulmonary Inflammation;Pulmonary Tuberculosis;Research;Research Design;Research Personnel;Research Project Grants;respiratory;Respiratory Disease;response;Risk;Risk Factors;Role;Science;Severities;Source;Statistical Models;Study models;Study Subject;systemic inflammatory response;Temperature;Testing;Time;Time Series Analysis;TLR3 gene;TLR7 gene;Toxicology;Traction;Training;Tuberculosis;Universities;Variant;Viral;viral epidemic;Viral Respiratory Tract Infection;virology;Virus;Virus Diseases;Visit;Work

PROJECT_TITLE: 2/1 - Mongolian Center for Environmental & Occupational Health - Mongolia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Q(70)R]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Neurosciences

ORG_CITY: Farmington

ORG_NAME: QUERCUS MOLECULAR DESIGN, LLC

ORG_STATE: CT

PHR: Narrative: Infections produced by the fungal pathogen Cryptococcus neoformans are a significant cause of mortality in the immunosuppressed population and are difficult to treat owing to CNS involvement and drug resistance. QMD is developing a new therapeutic candidate that inhibits an important metabolic pathway in this organism.

PI_NAMEs: WRIGHT, DENNIS L. (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: advanced disease;Amphotericin;Amphotericin B;analog;Animal Model;Annual Reports;anti-fungal agents;antimicrobial;Area;Binding Proteins;Blood - brain barrier anatomy;blood-brain barrier crossing;brain tissue;Candida glabrata;Case Study;Central Nervous System;Cessation of life;Clinical;clinical application;Columbidae;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus;Cryptococcus gattii;Cryptococcus neoformans;Death Rate;design;Development;Dihydrofolate Reductase;Dihydrofolate Reductase Inhibitor;Disease;Dose;drug development;Drug Kinetics;Drug or chemical Tissue Distribution;Drug resistance;Drug Targeting;effective therapy;efficacy evaluation;efficacy study;Elements;Encapsulated;Environment;Enzymes;Evaluation;Event;Evolution;experimental study;Feces;Fluconazole;Fluconazole resistance;Flucytosine;Folic Acid Antagonists;Formulation;fungus;Goals;Health;Hematogenous Spread;HIV;Homelessness;Human;Immune system;Immunocompromised Host;immunosuppressed;improved;In Vitro;in vivo;in vivo evaluation;indexing;Individual;Infection;Infiltration;Inhalation;inhibitor;Kinetics;Lead;lead candidate;lead optimization;Life;Lung;Lung infections;Measurable;medically underserved population;Meninges;Meningitis;Metabolic;Metabolic Pathway;Metabolism;Modeling;Modification;mortality;mouse model;Mus;Mycoses;novel;novel therapeutics;nucleic acid biosynthesis;Opportunistic Infections;Organ;Organism;Outcome;pathogen;pathogenic fungus;Pathogenicity;patient population;Patients;pharmacokinetics and pharmacodynamics;Phase;Plasmodium falciparum;Population;preclinical evaluation;preference;Property;Regimen;Reproduction spores;Resistance;resistance mechanism;Risk;Route;scale up;Series;Small Business Technology Transfer Research;Soil;Sulfamethoxazole;synergism;targeted treatment;Therapeutic;therapeutic candidate;Toxic effect;Toxoplasma gondii;Treatment Cost;treatment planning;treatment program;United States;Work;Yeasts

PROJECT_TITLE: Therapeutic Agents Targeting Cryptococcal Infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Prevention;Suicide;Suicide Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE To advance prediction and prevention of suicide, a leading cause of death, we need more precise understanding of who needs what intervention and when through investigation of proximal risk factors, and impulsivity is an ideal candidate. The proposed research will use digital monitoring of patients at high risk for suicide to conduct the first intensive longitudinal assessment of multiple components of impulsivity and suicidal urges in real time among individuals at high risk for suicide. Findings will improve understanding of impulsivity as a transdiagnostic short-term risk factor for suicide, laying the groundwork for development of targeted interventions for suicide prevention, and may be generalizable to other impulsive behaviors.

PI_NAMEs: FORTGANG, REBECCA GWEN (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Accident and Emergency department;Adult;Affect;Award;Behavior;Behavioral;Biological Markers;career development;Cause of Death;Clinical;clinical decision-making;Data;Data Analyses;Data Set;Decision Making;Detection;Development;Diagnostic;digital monitoring;digital phenotyping;Distal;Ecological momentary assessment;Elements;Environment;experience;Fatigue;Feeling hopeless;Feeling suicidal;Funding;Future;General Hospitals;germine;Goals;Grain;high risk;Hospitalization;improved;Impulsive Behavior;Impulsivity;Individual;inferential statistics;Intervention;Investigation;Jordan;Knowledge;Left;Life;Link;Machine Learning;Manuscripts;Maps;Massachusetts;Measures;medical schools;Mentors;Mentorship;Methods;mobile computing;Modeling;multidisciplinary;multimodality;National Institute of Mental Health;network models;novel;Outcome;Participant;Patient Monitoring;Patient Self-Report;Patients;Pattern;Positioning Attribute;Predictive Analytics;Prevention;Process;programs;Psychiatric therapeutic procedure;Psychiatry;Public Health;Publishing;real time monitoring;Research;Research Priority;Research Proposals;Resources;Risk;Risk Factors;Sampling;Science;screening;skills;Sleep Deprivation;Statistical Models;Subgroup;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Telephone;Testing;therapy development;Time;time interval;Training;trait;trait impulsivity;Work

PROJECT_TITLE: Digital Monitoring of Impulsivity as a Proximal Risk Factor for Suicidal Outcomes

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Lung;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PEDIATRICS

PHR: Narrative Human diseases with multi-organ comorbidities are often misdiagnosed and require more complex clinical management. These comorbidities commonly include congenital defects present at birth including heart, lung, and limb defects, with some requiring immediate corrective surgery. Understanding how and why these comorbidities form in the first place can provide clinicians with more information about which disease symptoms are likely to co-occur, and whether we can devise treatment strategies compatible across disease groups.

PI_NAMEs: LALONDE, ROBERT L (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Adult;Advisory Committees;Affect;ALDH1A2 gene;Bar Codes;Birth;Blood Vessels;Body System;Branchial arch structure;Cardiac;cardiogenesis;Cardiovascular system;career;career development;Cell Lineage;cell type;Cells;Clinical Management;Collaborations;Communication;comorbidity;Complex;Congenital Abnormality;CRISPR/Cas technology;Data;Defect;Development;Development Plans;Developmental Biology;Diagnosis;Diagnostic;Disease;disease phenotype;Educational process of instructing;Embryo;Experimental Designs;experimental study;Fibroblast Growth Factor;Forelimb;fundamental research;GATA4 gene;Genes;genetic approach;genome sequencing;Goals;Health;Heart;heart defect;Heterogeneity;Human;human disease;Image;improved;Individual;insight;Institution;Joints;Label;Lateral;Light;Limb Development;Limb structure;Link;Lung;lung development;Medical;Mentors;Mentorship;Mesoderm;Microscopy;model organism;Modeling;Mutagenesis;Mutation;Nature;Operative Surgical Procedures;Organ;Patients;Pattern;Pectoral;pediatric department;Phase;Phenotype;progenitor;Research;Research Personnel;Research Proposals;Resources;Severities;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skeleton;Specific qualifier value;stem cell population;stem cells;Structure;success;supportive environment;Symptoms;Testing;therapeutic development;Tissues;Training;transcriptome;transcriptomics;Transgenic Organisms;treatment strategy;whole genome;Work;Writing;Zebrafish

PROJECT_TITLE: Mechanisms of human appendicular and cardiovascular comorbidities: An analysis of heterogeneity and lineage trajectories of the lateral plate mesoderm

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(JA)]


NIH_SPENDING_CATS: Aging;Nutrition;Obesity;Prevention

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: PROJECT NARRATIVE Insulin resistance (IR) is a pathological state strongly associated with both obesity and aging, and represents a major risk factor for metabolic dysfunction, frailty, heart disease, stroke and dementia. Other than exercise and weight loss, limited mechanism-based strategies exist to improve IR and physical function. Here, we propose to examine the role of a specific cell population in IR associated with obesity using our novel animal model along with a cutting-edge technology, single cell transcriptomics. This project is likely to provide a deeper understanding of IR and lay the foundation for the drug development to alleviate IR and physical dysfunction.

PI_NAMEs: XU, MING  (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Affect;age acceleration;age related;age-related disease;Aging;American;Animal Model;Automobile Driving;Biological Aging;Body Weight decreased;CDKN2A gene;Cell Aging;Cells;Chronic Disease;clinically relevant;Complement;Coupled;Data;Dementia;diet and exercise;disability;drug development;Elements;Enterobacteria phage P1 Cre recombinase;Estrogen Receptors;Exercise;experience;extend lifespan;Foundations;frailty;Functional disorder;Future;Genes;Goals;healthspan;Heart Diseases;Heterogeneity;improved;in vivo;in vivo Model;innovation;insight;Insulin;Insulin Resistance;Intervention;Kinetics;life span;loss of function;Metabolic;Metabolic dysfunction;Modeling;Monitor;mouse model;Natural History;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obese Mice;Obesity;Outcome;Pathologic;Pathology;Pathway interactions;pharmacologic;Physical Function;Physical Performance;Play;Population;Population Heterogeneity;Prediabetes syndrome;prevent;Proliferating;promoter;Research;Resistance;Resistance development;Resources;Risk;Risk Factors;Role;sarcopenia;screening;senescence;senescent cell;Stress;Stroke;Tamoxifen;Technology;Testing;Therapeutic;Tissues;transcriptomics;Transgenic Mice;translational potential;Work

PROJECT_TITLE: Targeting p21-positive Senescent Cells in vivo for Alleviating Metabolic and Physical Dysfunction

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Nutrition;Obesity

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: The proposed research project is a feasibility and usability study of utilizing cutting-edge computer science methods – conversational agents, neural attention, transformers, supervised policy learning, variational autoencoders, and adversarial training – to develop an artificially intelligent agent for automated motivational interviewing counseling with a focus on weight loss. The proposed agent will circumvent barriers to healthcare providers' adoption of motivational interviewing, lack of fidelity to MI theory by human counselors, mitigate the issue of limited access to counseling services and complement human counselors in the behavioral healthcare delivery model.

PI_NAMEs: KOTOV, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: LONG, SYLVIA ELISABETH

PROJECT_TERMS: Address;Adult;adult obesity;adversarial learning;animation;Architecture;Area;Artificial Intelligence;artificial intelligence method;Assessment tool;Attention;autoencoder;barrier to care;Behavior;behavior change;Behavior Therapy;Behavioral;behavioral health;Body Weight decreased;Cellular Phone;chatbot;Client;clinical diagnosis;clinical diagnostics;Code;Collection;communication behavior;Communications Media;Complement;computer science;computerized;cost;Counseling;Data Analyses;deep learning;Development;Family Practice;feasibility testing;Feedback;Foundations;Fright;Future;gaze;Geographic Locations;Gestures;handheld mobile device;Health;Health education;Health Personnel;Health Sciences;Healthcare;Human;Image;improved;innovation;intelligent agent;Intervention;Interview;Judgment;Language;Learning;learning network;Life;Literature;Medical;Medicine;Methods;Modernization;motivational enhancement therapy;Music;neural;neural network;neurodevelopment;novel;obese patients;Obesity;Participant;patient engagement;Patient Participation;Patients;Policies;Posture;practice-based research network;primary care practice;Procedures;Professional counselor;provider adoption;Province;Public Health;Publishing;Quantitative Evaluations;recruit;Research Project Grants;response;Service delivery model;Services;skills;Speech;Standardization;Structure;Tablets;Techniques;Technology;Text;theories;therapeutically effective;Time;Training;Transcript;United States;Universities;usability;Validation;virtual coach;Visual;Wait Time;Weight;weight loss intervention;Work

PROJECT_TITLE: Neural Conversational Agent for Automated Weight Loss Counseling

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]