ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Through the high quality gene expression data it has generated, ImmGen has become an important resource in Immunology research. This next cycle of funding will expand the definition of gene expression across the immune system, analyze how its regulatory hierarchy relates to immune responses. It will thus provide an essential foundation for the immunogenic understanding of immune responses in health and disease.

PI_NAMEs: BENOIST, CHRISTOPHE O. (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Artificial Intelligence;Autoimmune;Binding;Catalogs;Cell Lineage;cell motility;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chromatin;Chromatin Structure;cloud based;Code;Collection;Communities;community consultation;Computational Biology;Computer software;cost effectiveness;cytokine;Darkness;Data;data access;Data Set;Data Storage and Retrieval;data to knowledge;Dedications;Disease;Dissection;Electronics;Ensure;Epigenetic Process;epigenomics;Family;Feedback;Foundations;Funding;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Transcription;Genetic Variation;genome-wide;Genomics;Health;Histones;Immune;Immune response;Immune system;immunogenic;Immunogenomics;Immunologics;Immunology;insight;Interleukin-10;Interleukin-12;Interleukin-24;Intuition;Label;Laboratories;Location;Lymphoid;Lymphoid Cell;Machine Learning;Macrophage;Maps;Messenger RNA;methylome;mobile app development;multimodality;Mus;Myelogenous;Myeloid Cells;Organ;Pathway Analysis;Phenotype;Play;Population;Post-Translational Protein Processing;Property;Proteins;Reference Standards;Regulation;Research;Resolution;Resources;response;RNA;RNA Splicing;Role;Services;sex;sex variable;single-cell RNA sequencing;smartphone application;Sorting;Standardization;stem cells;Technology;tool;Transcript;transcription factor;transcriptome;transcriptome sequencing;Variant;web app;web site;Work

PROJECT_TITLE: ImmGen: Gene Expression and Regulation in Immune Cells


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PISCATAWAY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Meiosis is the process that generates eggs and sperm necessary for sexual reproduction. For reasons not completely understood, meiosis in females is highly error prone, leading to infertility, miscarriage, and birth defects. The long-term goal of this grant is to understand how meiosis occurs in eggs to shed light on why this process frequently goes awry in females.

PI_NAMEs: SCHINDLER, KAREN A (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Aneuploidy;aurora B kinase;aurora kinase A;Cell Division Process;Cell Line;Chromosome Pairing;Chromosome Segregation;Congenital Abnormality;Data;Diploidy;egg;Family;Family member;Female;Germ Cells;Goals;Grant;Haploidy;Human;Infertility;Knockout Mice;Malignant Neoplasms;Meiosis;member;Mitosis;Molecular;Oocytes;Phosphotransferases;precursor cell;Process;Protein Kinase;Proteins;segregation;Sequence Homology;Sexual Reproduction;Signal Transduction;Sister Chromatid;sperm cell;Spontaneous abortion;Woman;Work

PROJECT_TITLE: Signaling Mechanisms that Control Chromosome Segregation during Female Meiosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: public health relevance  is that knowledge can be used to reduce the burden of neurological disease for all people. This project will  also support early career scientists with training and career development programs to increase basic,  translational and clinical neuroscience expertise and ensure a vibrant, talented, and diverse work force.

PI_NAMEs: PADMANABHAN, KRISHNAN  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Address;Architecture;Area;Awareness;Beauty;Behavior;Biology;biophysical model;Books;Brain;calcium indicator;career;career development;Characteristics;Child;Clinical;Code;Complex;computational neuroscience;deep neural network;Dendritic Spines;design;Development;Disease;Education;Educational workshop;Ensure;Entropy;experimental study;Ferrets;Functional disorder;General Population;high school;Image;in vivo;Individual;Interdisciplinary Study;Knowledge;Lead;lectures;Link;Location;Measures;Mind;Modeling;Nature;Nervous System Disorder;neural;Neurobiology;Neurons;Neurosciences;next generation;novel;novel strategies;Output;outreach;Pattern;Pennsylvania;Persons;Physics;Population;Probability;Program Development;Property;public health relevance;Research Personnel;Science;Scientific Advances and Accomplishments;Scientist;Sensory;skills;Statistical Mechanics;statistics;STEM field;Structure;Synapses;synaptic function;Talents;theories;Training;Trees;two photon microscopy;undergraduate student;Universities;Visual Cortex;Weight;Work

PROJECT_TITLE: CRCNS: Linking Synaptic Populations and Computation Using Statistical Mechanics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(50)R]


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: KENT

ORG_DEPT: PHYSICS

ORG_NAME: KENT STATE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE Membrane proteins are key molecules for many cellular functions and play a role in every infectious and physiological disease. Knowledge of the molecular structure of membrane proteins is necessary to understand the underlying biophysical and molecular mechanisms of their function. This research will enable solving membrane protein structures with novel tools that are made from DNA molecules.

PI_NAMEs: SCHMIDT, THORSTEN LARS (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Biophysics;Cell Adhesion;Cell membrane;Cell Physiology;Cells;chemical property;chemical synthesis;Chemicals;Communicable Diseases;Communication;Computers;Disease;DNA;DNA chemical synthesis;Environment;FDA approved;Genetic;Human;Knowledge;Lipids;Membrane;Membrane Lipids;Membrane Proteins;Molecular;Molecular Structure;nanodisk;Nanostructures;Nature;novel;Nutrient;Pharmaceutical Preparations;Pharmacology;Physical environment;physical property;Physiological;Play;protein function;protein structure;Proteins;Research;Role;Salts;self assembly;Shapes;Stress;structural biology;Structure;Surface;Technology;tool;virology;Water

PROJECT_TITLE: Small and Mechanosensitive Membrane Proteins Studied with DNA-based Tools

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Based on our novel preliminary data we have identified pharmacologic inhibitors that can inhibit polarization of macrophages towards the proangiogenic M2-type population, which has been associated with progression of CNV. We hypothesize that selective pharmacologic inhibition of M2-type macrophage polarization can block CNV. Here, we will systematically test identified kinase and non-kinase inhibitors of M2-type macrophage polarization for their selectivity in blocking M2-type macrophage polarization and consequently CNV, with the aim to establish novel drugs for the treatment of neovascular AMD.

PI_NAMEs: MARNEROS, ALEXANDER GEORG (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: ABL1 gene;Ablation;Address;angiogenesis;Angiogenesis Inhibition;Angiogenesis Inhibitors;Antigen-Antibody Complex;Aqueous Humor;Area;Attenuated;Biological Assay;Blood Vessels;Cells;cellular targeting;Chemicals;Choroidal Neovascularization;clinically relevant;cytokine;Data;Data Analyses;Disease;Drug Screening;Endothelium;Event;experimental study;Exudative age-related macular degeneration;Eye;Genetic;genetic approach;Glucocorticoids;Heat-Shock Proteins 90;Histone Deacetylase;Histone Deacetylase Inhibitor;Impairment;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;inhibitor;Injections;innovation;Interleukin-10;Interleukin-13;Interleukin-4;Interleukin-6;Lasers;Lesion;Macrophage;macrophage-derived chemokine;MAP2K1 gene;Mediating;MEKs;Membrane;Modeling;Molecular;Molecular Target;mouse model;Mus;neovascularization;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Pathogenesis;Patients;Pharmaceutical Preparations;pharmacologic;Phase;phosphoproteomics;Phosphotransferases;Population;prevent;Process;Proteomics;Resources;Role;Signal Transduction;Site;small molecule;Testing;Therapeutic;therapeutic target;Time;Vascular Endothelial Growth Factors

PROJECT_TITLE: Proangiogenic M2-type macrophages and choroidal neovascularization

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Microbiome

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: NARRATIVE This proposal aims to fill important knowledge gaps regarding mechanism via which the bacterial type 9 secretion system of the gut microbiota impacts health. Via a multi-pronged experimental approach that uses genetics, biochemistry, biophysics, and murine models, we aim to gain a mechanistic understanding of T9SS machinery and the T9SS secretome of the gut microbiota.

PI_NAMEs: SHRIVASTAVA, ABHISHEK  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Animals;Bacteroides;Bacteroidetes;Biochemistry;Bioinformatics;Biological Models;biophysical model;Caspase;Chlorobi;Collection;Data;Dietary Fiber;Enzymes;experimental study;Extracellular Protein;Fermentation;Future;Genetic;Gram-Negative Bacteria;gut microbes;gut microbiota;Health;Health Benefit;Human;Immune;immunoregulation;Investigation;Knowledge;Metabolic Diseases;Metabolism;Microbe;microbial community;model organism;Motility;Motor;mouse model;Oligosaccharides;oral microbial community;pathogen;Pectate lyase;Prevotella;Production;Property;Protein Export Pathway;Protein Secretion;Proteins;Research Design;Resources;Role;Sensory;Shapes;Structure;System;Testing;Transportation;Volatile Fatty Acids

PROJECT_TITLE: Mechanistic investigation of bacterial type 9 secretion system machinery and its involvement in gut metabolism and immunomodulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Lung;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: The United States opioid epidemic started in 1999 and continues to grow, and in 2019, opioid induced respiratory depression – a severe slowing and shallowing of breathing – caused ~130 deaths per day. Our goal is to first identify the key neurons that opioids target to stop breathing and then to determine exactly what opioids do to them. This work will provide a platform for future studies to design and discover novel ways to prevent death from opioid overdose.

PI_NAMEs: YACKLE, KEVIN  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Acute;Address;Adult;Analgesics;ARRB2;Behavior;Behavioral;beta-arrestin;Brain;Brain Stem;Breathing;Cardiac pacemaker;Cessation of life;Clinical;Compensation;Data;design;excitatory neuron;experimental study;Future;Generations;Genetic;genetic approach;Goals;GTP-Binding Proteins;In Vitro;in vivo;inward rectifier potassium channel;Measures;Mediating;Mediator;Medicine;Modeling;Molecular;Motor Neurons;mouse genetics;Mus;neural;Neurons;nodal myocyte;novel;Opioid;opioid epidemic;opioid misuse;opioid mortality;opioid overdose;Opioid Receptor;opioid use;optogenetics;overdose death;Pacemakers;Pain management;pandemic disease;Pathway interactions;Periodicity;Persons;pharmacologic;Play;preBotzinger complex;presynaptic;prevent;receptor expression;Respiratory physiology;Role;side effect;Signal Pathway;Signal Transduction;Site;Societies;Synaptic Vesicles;System;Testing;Therapeutic;Time;United States;Ventilatory Depression;vesicular release;Work

PROJECT_TITLE: Utilizing opioid receptor expression to identify the neurons and molecules responsible for opioid respiratory depression and basal breathing.

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE We have developed a non-infectious, self-replicative SARS-CoV-2 replicon system that is a safe and effective tool for antiviral screening and amenable to genetic engineering for studying drug resistance. We have identified a small molecule inhibitor of SARS-CoV-2 antiviral activity, and early medicinal chemistry efforts have optimized this lead. This project aims to further identify and characterize compounds toward the development of novel inhibitors against SARS-CoV-2 with potent, nanomolar antiviral activity.

PI_NAMEs: SARAFIANOS, STEFAN G (contact);WANG, ZHENGQIANG

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Active Sites;Address;Affect;Air;airway epithelium;analog;Anti-viral Agents;Binding;Biochemical;Biological Assay;Biophysics;Caco-2 Cells;Cell Line;cell preparation;Cells;Cessation of life;Collection;combat;Combined Modality Therapy;Coronavirus;COVID-19;COVID-19 mortality;cytotoxicity;Data;Development;Disclosure;Disease;Disease Outbreaks;drug candidate;drug discovery;Drug Kinetics;Drug resistance;Effectiveness;efficacy study;Enzyme Kinetics;experimental study;expression cloning;fitness;Fluorescence Microscopy;Generations;Genes;Genetic Engineering;Genomics;Grant;helicase;Hepatitis B Virus;Hepatitis C virus;high throughput screening;HIV-1;HIV-2;Human;improved;In Vitro;in vivo;Individual;Influenza;inhibitor;innovation;International;invention;Kinetics;Lead;lead optimization;Legal patent;Libraries;Liquid substance;Measurement;Measures;Metals;meter;miniaturize;Molecular;monolayer;mortality;mouse model;Mus;Mutation;nanomolar;Nonstructural Protein;novel;pandemic disease;Pharmaceutical Chemistry;Plasmids;Preparation;Proteins;Public Health;Published Comment;Publishing;remdesivir;Replicon;Reporting;Resistance;resistance mechanism;resistance mutation;RNA;SARS coronavirus;SARS-CoV-2 antiviral;SARS-CoV-2 B.1.1.7;SARS-CoV-2 B.1.351;SARS-CoV-2 CAL.20C;SARS-CoV-2 inhibitor;SARS-CoV-2 P.1;screening;Severe Acute Respiratory Syndrome;small molecule inhibitor;small molecule libraries;socioeconomics;stable cell line;success;synergism;System;Technology;Testing;Time;tool;Transfection;Untranslated Regions;Vaccines;Variant;Viral;viral entry inhibitor;Viral Physiology;Virus;Virus Diseases;Visualization;Washington;Work;ZIKA

PROJECT_TITLE: Discovery of SARS-CoV-2 antivirals using a replicon assay

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-V(02)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Neurodegenerative;Neurosciences

ORG_NAME: ROCHESTER INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Living cells contain organelles which have specific functions related to their characteristic shapes and sizes. Our proposed research program will elucidate the design principles required for these organelles to maintain their size while sharing a common pool of their building blocks. A quantitative understanding of molecular mechanisms affecting organelle growth will accelerate the development of new therapies to combat many diseases like Amyotrophic Lateral Sclerosis (ALS) and neurodegenerative disorders like Parkinson’s and Alzheimer’s disease.

PI_NAMEs: MOHAPATRA, LISHIBANYA  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TITLE: Design Principles of Size-Control of Organelles Growing in a Shared Pool of their Building Blocks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


NIH_SPENDING_CATS: Genetics;Infertility

ORG_CITY: DAVIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative The repair of DNA breaks by homologous recombination is essential for meiosis, the cellular process that produces sperm and eggs. This proposal addresses a critical gap in our understanding of the molecular processes responsible for ensuring crossing over between homologous chromosomes. Defects in meiotic recombination are associated with infertility, pregnancy loss, congenital disease and ovarian insufficiency.

PI_NAMEs: HUNTER, NEIL  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;Binding;Biochemical;Biology;Cell division;Cell Physiology;Chromosome Pairing;Chromosome Segregation;Chromosomes;Closure by clamp;cohesion;Complement;Complex;Coupled;Cruciform DNA;Data;Defect;Development;Disease;DNA;DNA biosynthesis;DNA Double Strand Break;DNA Repair;egg;endonuclease;Ensure;Eukaryota;Event;Excision;Family;Genetic;genetic analysis;Genetic Crossing Over;Genetic Recombination;Germ Cells;Haploidy;helicase;Homologous Gene;homologous recombination;Human;In Vitro;in vitro Model;in vitro testing;in vivo;in vivo evaluation;in vivo Model;Infertility;insight;Joints;Knowledge;Mediating;Meiosis;Meiotic Prophase I;Meiotic Recombination;member;migration;Mismatch Repair;MLH1 gene;Modeling;Molecular;Molecular Genetics;novel;novel strategies;Orthologous Gene;Ovarian;Pathology;Pathway interactions;Pattern;phosphoproteomics;Phosphorylation;Play;PLK1 gene;Ploidies;precursor cell;predictive modeling;Pregnancy loss;primary ovarian insufficiency;Process;Prokaryotic Cells;prospective;Proteins;Reaction;Reagent;reconstitution;recruit;Regulation;Resolution;Resolvase;Role;Saccharomycetales;segregation;Side;Sister Chromatid;Site;Specificity;sperm cell;Spontaneous abortion;Surgical incisions;targeted nucleases;Testing;Time;tool;Topoisomerase III;Zonula Adherens

PROJECT_TITLE: Joint Molecule Resolution During Meiotic Recombination

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Genetics;Human Genome;Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: TULSA

ORG_NAME: LAUREATE INSTITUTE FOR BRAIN RESEARCH

ORG_STATE: OK

PHR: Project Narrative Identifying genetic effects on complex traits is a critical step in the quest to establish causal mechanisms. Our research program focuses on identifying and quantifying the genetic basis of developmental differences in the human brain during adolescence, using unbiased approaches for identifying associated genes, determining genetic relationships, and profiling the impact of genetic predisposition for diseases in longitudinal Adolescent Brain Cognitive Development (ABCD) data. Our proposal utilizes innovative approaches to achieve the analytic goals and reduce the risks of spurious associations from admixed and related participants.

PI_NAMEs: FAN, CHUN CHIEH  (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Admixture;Adolescence;Adolescent;Adult;Age;Automobile Driving;Behavior Disorders;Behavioral;Brain;Brain region;Clinical;cognitive development;cognitive system;cohort;Communities;Complex;Computer software;critical period;Data;Data Analyses;data archive;Data Set;design;Detection;Development;Dimensions;Disease;Disparate;Emotional;Ensure;Epidemiology;Exhibits;Genes;Genetic;genetic analysis;Genetic Predisposition to Disease;Genetic Risk;genome wide association study;genome-wide;genomic locus;Goals;high dimensionality;Human;Image;improved;Individual;Individual Differences;individual variation;innovation;instrument;Measurement;Measures;Mental disorders;Methods;Modality;Modeling;Molecular;Multimodal Imaging;multimodal neuroimaging;National Institute of Mental Health;Neuroanatomy;neurodevelopment;neuroimaging;neuropsychiatric disorder;Neurosciences;novel;novel strategies;Participant;Pattern;Phenotype;Population;Population Genetics;Principal Component Analysis;Process;programs;psychiatric symptom;public health intervention;Research;Research Personnel;Risk;Risk Behaviors;Sampling;serial imaging;Source;Staging;Structure;System;Therapeutic;Time;tool;trait;Variant

PROJECT_TITLE: Identifying and quantifying genetic effects on neurodevelopmental trajectories in adolescents

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Cerebrovascular;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Orphan Drug;Parkinson's Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CAMBRIDGE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Parkinson’s disease (PD) and Amyotrophic Lateral Sclerosis (ALS) are irreversible neurodegenerative diseases with limited disease-modifying therapeutics. During the course of these diseases, cerebrovascular changes have been documented by brain imaging, histological, and transgenic mouse studies, however early changes in cerebrovascular gene expression during sporadic human disease with cell type-specificity and whole genome- resolution are not known; thus, the causal role of cerebrovascular dysfunction on disease progression is not established and represents an underexplored therapeutic target. The goals of this project are to characterize early cerebrovascular dysfunction using unbiased transcriptomic profiling of post-mortem brain tissue from PD and ALS patients, and establish whether iPSC-derived models of the cerebrovasculature mimic disease phenotype.

PI_NAMEs: LINVILLE, RALEIGH MILLER (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Affect;Age;alpha synuclein;ALS patients;Amyotrophic Lateral Sclerosis;angiogenesis;Animal Model;Astrocytes;Atlases;Autopsy;Benchmarking;Blood - brain barrier anatomy;Blood flow;Blood Vessels;Brain;brain endothelial cell;Brain imaging;Brain Stem;brain tissue;cell age;Cell Nucleus;cell type;Cells;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Cessation of life;Chemicals;Collaborations;computational pipelines;Cytoplasm;Development;Disease;disease phenotype;Disease Progression;Dissection;dopaminergic neuron;Etiology;Excision;Extravasation;familial amyotrophic lateral sclerosis;Fibroblasts;Functional disorder;Future;Gene Expression;gene regulatory network;Genetic Transcription;genome-wide;Goals;Histologic;Human;human disease;human tissue;imaging probe;Immune;Immunofluorescence Immunologic;In Situ Hybridization;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Link;Microglia;Modeling;Molecular;Motor;Motor Cortex;motor neuron degeneration;Motor Neurons;motor symptom;Neurodegenerative Disorders;Neuroglia;Neurologic;Neurons;new therapeutic target;Nutrient;overexpression;Paralysed;Parkinson Disease;Pathologic;Pathology;patient derived induced pluripotent stem cells;Patients;Pericytes;Phenotype;Population;Process;Protocols documentation;Recovery;Resolution;response;Role;Sampling;single cell technology;single nucleus RNA-sequencing;Site;Skeletal Muscle;Smooth Muscle Myocytes;Specificity;Spinal Cord;sporadic amyotrophic lateral sclerosis;sporadic Parkinson's Disease;stem cell model;Stress;Substantia nigra structure;Supporting Cell;targeted treatment;Testing;Therapeutic;therapeutic target;Tissues;tool;trafficking;transcription factor;transcriptomic profiling;Transgenic Mice;wasting;whole genome;Work

PROJECT_TITLE: Single Cell Dissection of Cerebrovascular Dysfunction in Parkinson's Disease and Amyotrophic Lateral Sclerosis

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Patient Safety;Precision Medicine;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: SPARTANBURG

ORG_NAME: SPARTANBURG REGIONAL MEDICAL CENTER

ORG_STATE: SC

PHR: Project Narrative/Relevance The Upstate Carolina Consortium will engage community physicians to participate in NCI supported, cancer care delivery research, treatment, prevention and cancer control trials. Upstate Carolina Consortium serves a large rural, minority, and underserved population and is committed to increasing NCI clinical trial access and participation among this population that will reduce cancer disparities and the burden of cancer. The Consortium’s goal is to support practice-changing cancer prevention, treatment and cancer control research that will improve patient outcomes and quality of life.

PI_NAMEs: BEARDEN, JAMES D;CURTIS, AMARINTHIA E (contact);KILBURN, JEREMY

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Acceleration;Address;Adolescent and Young Adult;Adopted;Adoption;African American;African American population;aging demography;Area;Awareness;base;Cancer Burden;cancer care;Cancer Control;Cancer Control Research;cancer health disparity;Cancer Patient;cancer prevention;care delivery;Catchment Area;Clinical Research;Clinical Trials;Communities;Community Clinical Oncology Program;community engagement;Community Hospitals;Community Participation;Community Physician;Community Practice;community research;community setting;control trial;Data;design;Development;Disparity;Emergency Medicine;Enrollment;Ensure;experience;Facebook;Gastroenterology;Goals;Gynecologic;health care delivery;health care disparity;human subject protection;improved;Incidence;insight;Institution;long-standing disparities;Malignant Neoplasms;Medical;Medical Oncologist;medical specialist;Minority Groups;mortality;multidisciplinary;next generation;North Carolina;novel;Oncologist;Operative Surgical Procedures;Outcome;Pathologist;Pathology;patient oriented;Patient-Focused Outcomes;Patients;Population;precision medicine;Precision medicine trial;Prevention;Primary Care;Primary Care Physician;Principal Investigator;programs;protocol development;Provider;Qualifying;quality assurance;Quality of life;Radiation;Radiation Oncologist;Radiology Specialty;Recording of previous events;Research;Research Design;Research Personnel;Resources;Rural Population;screening;social media;socioeconomics;South Carolina;Specialist;Structure;success;Surgeon;System;Training;Twitter;Underrepresented Populations;Underserved Population;Urology

PROJECT_TITLE: Upstate Carolina Consortium - Community Oncology Research Program


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Immunotherapy;Transplantation

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: High-risk corneal transplantation, performed in inflamed host graft beds, is characterized by swift and often irreversible immune rejection. While tens of thousands of these are performed annually on a global basis, there has been no significant change in these poor outcomes for decades. This grant proposes to study the function of regulatory T cells in the development of immunity to high-risk corneal transplants and develop novel strategies to promote tolerance and long-term survival of these grafts without use of toxic immunosuppressive medications.

PI_NAMEs: DANA, REZA  (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Address;angiogenesis;Angiogenesis Inhibitors;Anti-Inflammatory Agents;Antigen-Presenting Cells;Area;Beds;Cell Maturation;Cell Physiology;Cell Proliferation;Coculture Techniques;Cornea;CTLA4 gene;cytokine;Cytoprotection;Data;design;Development;differential expression;draining lymph node;efficacy evaluation;experience;FOXP3 gene;Functional disorder;Functional impairment;functional status;Funding;Generations;Graft Survival;Grant;Health;high risk;Homeostasis;Homing;IL2RA gene;Immune;Immune response;Immune Tolerance;Immunity;Immunobiology;Immunology;In Vitro;in vivo;Incubated;Inflammatory;Injections;Interferon Type II;Interleukin-1 beta;Interleukin-10;Interleukin-12;Interleukin-6;Keratoplasty;Knowledge;Ligands;Lymphangiogenesis;Lymphoid Tissue;Mediating;Membrane;Modeling;Molecular;Morbidity - disease rate;Mus;novel;novel strategies;ocular surface;Outcome;Pharmaceutical Preparations;Phenotype;Physiological;pigment epithelium-derived factor;Population;programmed cell death ligand 1;Proliferating;receptor;Regimen;Regulation;Regulatory T-Lymphocyte;Research;Research Design;Risk;Role;Secretory Cell;Site;stem;Surgical sutures;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Tissues;TNFSF10 gene;trafficking;Transforming Growth Factor beta;Transplantation;Treatment Efficacy;vascular bed;Vascular Endothelial Cell;Vascularization;Work

PROJECT_TITLE: Mechanisms of Sensitization in High Risk Corneal Grafts


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE Globally, exposure to sociopolitical violence represents a serious threat to child and family development and wellbeing, yet research on care for these populations has yielded few rigorous, RCT evaluations of programs, overall small treatment effects, and a dearth of family-based approaches to care (Cummings et al., 2017; Jordans et al., 2016). The proposed research is relevant to public health in low-& middle-income countries because it provides a rigorous test of an innovative, evidence-based and cost-effective intervention that is readily scalable to support better family functioning, tests mechanisms of effect and pathways of intervention for program impact, and evaluates organizational factors contributing to program effects, all in the context of an RCT designed clinical trial. This proposal is in response to RFA-MH-21-160, and is specifically relevant to NIMH’s mission because it contributes to the understanding of mental health problems in youth and contributes to prevention and intervention by utilizing a family-systems approach to improving the family environment, which is a crucial developmental context with implications for mental health and processes underlying adjustment.

PI_NAMEs: CUMMINGS, EDWARD MARK (contact);MILLER-GRAFF, LAURA E.

PROGRAM_OFFICER_NAME: CAMPBELL-ROSEN, HOLLY RENEE

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;adolescent mental health;Affect;Aftercare;Behavioral;Caring;Child;Child Support;Child Welfare;Chronic;Clinical;Clinical Trials;Clinical Trials Design;Cognitive;Communities;Conflict (Psychology);coping;cost effective;cost effective intervention;Counseling;Data Collection;Development;Dimensions;Ecology;Ecosystem;effective intervention;effectiveness evaluation;efficacy evaluation;Emotional;Ensure;Environment;Evaluation;evidence base;Evidence based intervention;Evidence based program;Exposure to;Family;family support;follow-up;Future;Goals;high risk;improved;Individual;innovation;Intervention;intervention program;longitudinal design;low and middle-income countries;Mediating;Mental Health;Mental Processes;Methodology;Methods;Mission;Modeling;National Institute of Mental Health;novel;Outcome;parenting intervention;Parents;Pathway interactions;Personal Satisfaction;Pilot Projects;Policy Research;Politics;Population;Prevention;Procedures;Process;Program Acceptability;Program Evaluation;programs;Psychopathology;Psychosocial Assessment and Care;Public Health;Randomized;randomized, clinical trials;Reaction;Recording of previous events;Research;Research Personnel;Research Training;resilience;Resource-limited setting;Resources;response;Risk;Safety;Security;Site;social;Social Processes;Surveys;System;Systems Theory;Testing;theories;Time;Trauma;treatment as usual;treatment effect;Violence;violence exposure;West Bank;Work;Youth

PROJECT_TITLE: An evidence-based family support program for parents and children in Palestine: A theory-based intervention


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Depression;Genetics;Human Genome;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Suicide

ORG_CITY: TUCSON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: Contact PD/PI: Vladimirov, Vladimir I Narrative: The main goal of this application is to identify the neurobiological mechanisms by which risk genetic variants associated with major depression (MDD) from large GWAS of MDD affect miRNA expression and functions in a large postmortem brain sample composed of 200 MDD cases and 200 matched controls.

PI_NAMEs: VLADIMIROV, VLADIMIR IVANOV (contact)

PROJECT_TERMS: Affect;Amygdaloid structure;Anterior;Autopsy;Biological;Biological Assay;Biology;Brain;Brain region;cingulate cortex;Clinical;Code;Collaborations;Collection;Data;Data Analyses;Data Discovery;data integration;Data Set;Development;Diagnosis;Disease;disorder risk;effective therapy;Etiology;falls;Functional disorder;Gene Expression;Genetic;genetic association;Genetic Risk;Genetic Transcription;genetic variant;genome wide association study;genome-wide;Genotype;Goals;improved;insight;Intervention;Knowledge;Lead;Linear Regressions;Major Depressive Disorder;Mental disorders;Messenger RNA;MicroRNAs;miRNA expression profiling;Molecular;Morbidity - disease rate;National Institute of Mental Health;Nerve Degeneration;neurobiological mechanism;Neurobiology;neurodevelopment;neuropathology;neuropsychiatric disorder;non-genetic;novel;Pathology;Patients;pharmacologic;Phenotype;Play;Process;protein structure;Proteins;Protocols documentation;Recording of previous events;Recurrence;Research;Research Personnel;Resources;Risk;Risk Factors;risk variant;Role;Sample Size;Sampling;Series;severe mental illness;Single Nucleotide Polymorphism;Substance abuse problem;Suicide;Suicide attempt;synaptogenesis;System;Testing;Time;Tissues;trait;transcriptome;transcriptome sequencing;Universities;Variant;Virginia;virtual;whole genome

PROJECT_TITLE: Assessing miRNA expression in the Corticolimbic System of Major Depressive Disorder


ADMINISTERING_IC: HL

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Physical Activity;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: NORFOLK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: OLD DOMINION UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative The proposed research aims to pilot test a group-based physical activity intervention for cardiovascular disease (CVD) prevention that harnesses components of social support, sense of belonging, and social connectedness to reduce social isolation and loneliness among reintegrating veterans following military service. The proposed training and research program will outfit the candidate with expertise necessary for conducting community- engaged research and mixed methods study design to conduct behavioral randomized control trials, both critical for the addressing the growing public health epidemic of social isolation and loneliness. Findings from the proposed studies may have significant implications on how to reduce social isolation and loneliness, and related CVD biomarkers (i.e., blood pressure) at a magnitude to drive long-term health benefits among vulnerable populations.

PI_NAMEs: YARISH, NATALIE MARIE (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: acceptability and feasibility;active duty;Address;adherence rate;American;Anxiety;Area;behavior change;Behavioral;behavioral and social science;Biological Markers;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;career;Cigarette;college;Communities;community engaged research;Coronary heart disease;cost effective;Data;design;Development;digital;digital technology;Environment;Epidemic;Ethics;Evaluation;exercise intervention;experience;Family;Feeling;Feeling suicidal;Fostering;Goals;Grant;Health;Health Benefit;improved;Individual;Intervention;Interview;Knowledge;Knowledge acquisition;Left;Life;Loneliness;lonely individuals;Manuscripts;Measures;men;Mental Depression;Mentorship;Methods;military men;Military Personnel;military service;military women;Physical activity;pilot test;Population;Populations at Risk;Post-Traumatic Stress Disorders;Program Evaluation;programs;Public Health;Randomized, Controlled Trials;Reporting;Research;research and development;Research Design;Research Personnel;Research Training;Risk;Sampling;satisfaction;skills;Smoking;social;Social Interaction;Social isolation;social relationships;social science research;Social support;social vulnerability;Societies;stroke risk;Structure;Surveys;therapy design;Training;Universities;Veterans;Vulnerable Populations;webinar;Woman;Writing

PROJECT_TITLE: Reducing social isolation and loneliness through physical activity to lower cardiovascular disease risk among military women and men reintegrating into civilian life

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: Nashville

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: NARRATIVE The purpose of this MIRA research renewal proposal is to discern the cellular mechanisms that govern nucleic acid-induced immune activation. We investigate the functions of cellular RNA binding proteins and how their regulation of host or pathogenic transcripts impact the innate immune response or modulate viral replication. We also seek to understand the mechanisms by which the central DNA sensor-triggered pathway elicits its activity in activating an immunologic transcriptional response; overactivation of this pathway causes autoimmune disorders, whereas under-activation can lead to reduced immune fitness and tumor immunosurveillance.

PI_NAMEs: ASCANO, MANUEL  (contact)

PROJECT_TERMS: Anti-viral Response;Autoimmune Diseases;Biological;Biology;Cell Physiology;Cells;Critical Pathways;cytokine;Detection;Development;Disease;DNA;DNA Damage;DNA-Binding Proteins;Environment;fitness;Funding;Gene Expression;gene regulatory network;Genetic Transcription;Goals;Health;Human;Immune;immune activation;Immune response;immunogenic;Immunologic Surveillance;Immunologics;immunoregulation;Infection;inhibitor;Innate Immune Response;interest;Interferons;Investigation;Knowledge;Laboratories;Mission;Modeling;Natural Immunity;novel;Nucleic Acids;pathogen;Pathogenicity;Pathway interactions;Post-Transcriptional Regulation;posttranscriptional;prevent;programs;Protein Biochemistry;Protein Family;Regulation;Research;response;RNA;RNA-Binding Proteins;Role;sensor;Shapes;small molecule;Stimulator of Interferon Genes;Stimulus;Transcript;Transcriptional Activation;tumor;Viral;Viral Genome;Virulence;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Deciphering Post-transcriptional Gene Regulatory Networks During Periods of Host-Pathogen Interaction and Innate Immune Activation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative This project will examine the mechanisms by which pupil-linked arousal modulates information processing in the brain. Dysregulation of the pupil-linked arousal system has been implicated in major clinical disorders, including schizophrenia, Parkinson’s disease, and depression, evidenced by abnormal pupil dynamics reported in individuals with the disorders. Therefore, the results of the proposed project will contribute to the knowledge base, potentially leading to more effective diagnosis and improved treatment of the disorders.

PI_NAMEs: WANG, QI  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Ablation;Acetylcholine;adeno-associated viral vector;Adrenergic Receptor;Affect;Afferent Neurons;Arousal;Attention;Attention deficit hyperactivity disorder;awake;barrel cortex;Behavior;behavior prediction;Behavioral;behavioral impairment;Behavioral Paradigm;Biosensor;Brain;Brain Diseases;Brain region;Brain Stem;Cerebral cortex;cholinergic;Cholinergic Receptors;Clinical;Code;Cognition;common symptom;Complex;cost;CRISPR/Cas technology;Detection;Development;Diagnosis;Disease;Electrophysiology (science);experimental study;Genetic;genetic manipulation;Goals;Guide RNA;Head;Health;improved;indexing;Individual;information processing;insight;Knock-out;Knowledge;knowledge base;Lighting;Link;locus ceruleus structure;Maps;Measures;Mediating;Mental Depression;Mental disorders;Molecular;Mus;Mydriasis;Nervous System Disorder;neural;Neurons;neuropsychiatric disorder;neuroregulation;noradrenergic;Norepinephrine;norepinephrine system;novel;Outcome;Parkinson Disease;Perception;Performance;Persons;Play;Property;Psyche structure;Psychometrics;Pupil;receptor;Reporting;response;Role;Schizophrenia;sensor;Sensory;Short-Term Memory;Signal Transduction;Stimulus;System;Tactile;Technology;Testing;Thalamic structure;tool;translational impact;Vibrissae;Work

PROJECT_TITLE: Noradrenergic and Cholinergic Mechanisms Underlying Pupil-linked Arousal Modulation of Thalamic Sensory Processing

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE This project will identify successful PrEP policies for reducing HIV transmission nationally, among MSM, and Black, Hispanic, and White MSM. If successful, the findings will advance the Ending the HIV Epidemic goals and produce actionable data to improve health justice in the United States.

PI_NAMEs: FAYAZ FARKHAD, BITA  (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Affordable Care Act;Age;American;Area;Artificial Intelligence;Attitude;Award;Behavior;Behavior Control;Behavioral;Big Data;black men who have sex with men;Black race;career;Caring;Case Management;compare effectiveness;comparison intervention;Computing Methodologies;condoms;cost;Cost Sharing;Data;Data Analyses;Data Science;Data Sources;Databases;demographics;design;econometrics;economic impact;Economic Policy;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Electronics;Environment;Epidemic;Epidemiology;Equation;ethnic disparity;Excision;experience;Federal Government;Foundations;Future;Goals;Health;health care availability;health disparity;health inequalities;health plan;Health Policy;Hispanic;HIV;HIV Infections;Human immunodeficiency virus test;Image;improved;Incidence;innovation;Instagram;Intervention;Justice;Knowledge;Latino;Link;Lived experience;longitudinal analysis;longitudinal database;marginalization;Mathematics;Measures;Mediating;Mediator;Medicaid;men;men who have sex with men;Mentors;Mentorship;Methodology;Methods;Modeling;National Institute of Allergy and Infectious Disease;Natural experiment;Not Hispanic or Latino;Outcome;Pathway interactions;Pennsylvania;Persons;Pharmaceutical Preparations;Pharmacy facility;Policies;Policy Analysis;Population;Positioning Attribute;pre-exposure prophylaxis;prior authorization;programs;prospective;Provider;Psychosocial Assessment and Care;Public Health;racial disparity;Records;Regulation;Research;Research Personnel;Research Scientist Award;Role;Science;sex;skills;social;social health determinants;social media;Social Sciences;social stigma;Solid;State Government;success;Surveys;Techniques;Telemedicine;Testing;Text;theories;Training;transmission process;Twitter;United States;United States National Institutes of Health;Universities;Update;uptake;Vulnerable Populations

PROJECT_TITLE: Assessing the Impact of Economic Policies on the Use of Pre-Exposure Prophylaxis in the United States

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: HANOVER

ORG_DEPT: CHEMISTRY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: This proposal describes a novel technological approach towards portable electroanalysis that merges modular chemically-precise sensing materials with seamless device integration on porous and flexible substrates. The molecular design relies on conductive porous scaffolds that serve as ultra-sensitive hosts and transducers for physiologically-relevant guests within electronic devices. Conceptual and technological advances emerging from this work will enhance the development of modular bioanalytical systems with potential impact in monitoring quality control of engineered tissue and wearable electronics.

PI_NAMEs: MIRICA, KATHERINE ANDREA (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: 3-Dimensional;Ascorbic Acid;Bioreactors;chemical stability;chemical synthesis;Chemicals;Coupled;design;Detection;Development;Devices;Dopamine;Electrodes;Electronics;Engineering;Environment;flexibility;Future;Glucose;Goals;Health;Healthcare;Homeostasis;improved;In Situ;Inflammation;interdisciplinary approach;Label;manufacturing process;Metabolism;Metals;mHealth;Molecular;Monitor;Morphology;nanoscale;neurochemistry;new technology;novel;Nutrient;Organ failure;patient oriented;Patients;Performance;Physiological;Porosity;portability;Process;Quality Control;Quality of life;Reporting;Research;scaffold;self assembly;Serotonin;solid state;Surface;System;Technology;technology platform;Time;Tissue Engineering;tissue support frame;Transducers;Trauma;Uric Acid;wearable device;Work

PROJECT_TITLE: Chemically Precise Framework Materials as a Modular Platform Technology for Electroanalysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PI_NAMEs: NEMETH, ELIZABETA  (contact)

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: Abbreviations;Aging;career;career development;Clinical Research;Collaborations;Communication;Communities;Development;Development Plans;disadvantaged background;diversity and equity;education research;Entrepreneurship;Extramural Activities;Faculty;Fostering;Funding;General Population;Goals;Grant;Health;improved;Individual;Inosine Diphosphate;Institution;Journals;K-Series Research Career Programs;Leadership;Los Angeles;Mentors;Mentorship;Minority;Monitor;novel;Outcome;Patients;Peer Review;Postdoctoral Fellow;professor;Program Development;programs;Publications;Publishing;Qualifying;recruit;Recruitment Activity;Research;Research Personnel;Resources;Scholars Program;Science;sharing platform;Societies;Structure;success;supportive environment;Training;Training and Education;Training Programs;Translational Research;translational scientist;Underrepresented Minority;Universities;Urban Health;Woman;Workforce Development;Writing

PROJECT_TITLE: Institutional Career Development Core


ORG_CITY: PITTSBURGH

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Innate immune systems provide critical defenses against microbial infections and are composed of both ancient and newly evolved proteins. To understand where our immune pathways came from and how they integrate new components, we study antibacterial responses in eukaryotes found across the Tree of Life. These diverse immune systems promise to yield new antimicrobials and to reveal how innate immune defenses can change over evolutionary time.

PI_NAMEs: LEVIN, TERA CATHERINE (contact)

PROJECT_TERMS: Amoeba genus;Animals;Anti-Bacterial Agents;Antibacterial Response;antimicrobial;Bacteria;Bacterial Infections;Biochemical;Cell model;Cells;Communicable Diseases;Dictyostelium;emerging pathogen;Environment;Eukaryota;Evolution;experimental study;flexibility;Genes;Genetic;Genomic approach;Haploidy;Immune;Immune system;Immunity;Infection;innate immune pathways;Innate Immune System;Life;microbial;Modernization;Molecular;Natural Immunity;novel;Organism;Pathway interactions;Phagocytes;Phylogenetic Analysis;Positioning Attribute;Proteins;Shapes;Signal Transduction;System;Time;tool;Trees

PROJECT_TITLE: The origins and evolution of eukaryotic antibacterial defenses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Many infectious diseases that harm humans originate from wildlife. This research will collect viral genome and gastrointestinal parasite data from red colobus monkeys, other nonhuman primates, and humans at Kibale National Park (Uganda) and develop new statistical analysis methods to quantify what conditions allow viruses to spread within and between the species that share the ecosystem.

PI_NAMEs: MILICH, KRISTA  (contact)

PROGRAM_OFFICER_NAME: JESSUP, CHRISTINE

PROJECT_TERMS: 2019-nCoV;Address;anthropogenesis;Area;Bayesian Analysis;Behavioral;Colobus Genus;Communicable Diseases;Communities;Data;deep learning;Disease;disease transmission;Ecology;Ecosystem;emerging pathogen;Epidemiology;Event;forest;gastrointestinal;Genetic;Human;Individual;Infection;infectious disease model;Interview;Methods;Modeling;nonhuman primate;novel;Parasites;pathogen;Pathogen detection;pathogenic virus;Pathway interactions;Persons;Phylogenetic Analysis;Population;Primates;Public Health;Research;Risk;Sampling;Satellite Viruses;simulation software;spillover event;Statistical Data Interpretation;Structure;Techniques;Technology;Testing;Time;Training;transmission process;Uganda;Viral;Viral Genome;viral transmission;virome;Virus;Zoonoses

PROJECT_TITLE: Phylogenetic modeling of viral transmission dynamics at the human-wildlife interface in Uganda


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Using data driven and computational approaches we will reveal fundamental mechanisms underlying viral infection, focusing on model systems that give insight into early, dynamic infection processes in diverse tissues, organisms, pathogens, and disease backgrounds. Gene networks and synergistic gene interactions causally related to infection will be inferred using our novel computational tools, thus uncovering signatures of protection and providing an invaluable resource for the community. The proposal promises to build approaches applicable across biological systems and processes, change our mechanistic understanding of viral infection, and, in the future, support therapeutic design.

PI_NAMEs: VAN DIJK, DAVID  (contact)

PROJECT_TERMS: Algorithms;Animal Model;Atlases;Biological;Biological Models;Biological Process;biological systems;causal variant;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Communicable Diseases;Communities;Complex;Computer Analysis;computerized tools;Computing Methodologies;Coupling;Data;Data Analyses;Data Collection;data integration;data modalities;design;Disease;Disease Outcome;Environment;Family;Future;gene interaction;gene network;Genes;Guidelines;Human;Immune response;In Vitro;in vivo;Infection;innovation;insight;large datasets;Learning;Logic;Machine Learning;machine learning algorithm;machine learning method;Methods;Modality;mouse model;novel;novel strategies;Organism;Organoids;pathogen;Phase;Physiological;Postdoctoral Fellow;predictive modeling;Predisposition;Process;Research;Resources;Severe Acute Respiratory Syndrome;single cell analysis;single cell technology;System;targeted treatment;Technology;Therapeutic;Therapeutic Intervention;Tissues;Training;Virus;Virus Diseases

PROJECT_TITLE: An integrative, data-driven, and computational approach to uncovering dynamic mechanisms of early viral infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Activity

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative (Public Health Relevance) Heart failure with preserved ejection fraction (HFpEF) is a common condition associated with high morbidity and very limited effective treatment options. Our HeartShare Clinical Center Team will leverage experience and expertise in cardiac imaging, exercise-based evaluation, omics-based research, bioinformatics, and geriatrics to comprehensively characterize HFpEF subtypes and advance our understanding of new treatment priorities.

PI_NAMEs: DESAI, AKSHAY SUVAS;GIVERTZ, MICHAEL M;LEWIS, GREGORY DYER (contact);SOLOMON, SCOTT DAVID

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Academic Medical Centers;adjudication;Amyloid;Amyloidosis;arterial tonometry;Artificial Intelligence;Bioinformatics;Biological Markers;Blood gas;Blood specimen;Blood Vessels;Body System;Cardiac;Cardiopulmonary;cardiovascular imaging;Classification;Clinical;Clinical assessments;clinical care;clinical center;clinical investigation;Clinical Pathways;Clinical Research;Clinical Treatment;Clinical Trials;Cognition;cohort;Collaborations;Computerized Medical Record;cost effective;Coupled;Data;data quality;design;Development;Diagnosis;Dyspnea;Echocardiography;effective therapy;EFRAC;Electronic Health Record;Enrollment;Epidemiology;Evaluation;Exercise;Exercise Test;experience;frailty;Functional disorder;Gases;General Hospitals;Geriatrics;Heart failure;heart function;heart imaging;heart preservation;hemodynamics;Hospitals;Human Subject Research;Image;Impairment;improved;Individual;insight;Institution;Integrated Health Care Systems;Intervention Trial;Laboratories;Leadership;Lung;Magnetic Resonance Imaging;Massachusetts;Measurement;medical specialties;member;Mentors;metabolomics;Morbidity - disease rate;multidisciplinary;Multimodal Imaging;multimodality;Musculoskeletal;National Heart, Lung, and Blood Institute;novel;novel therapeutic intervention;observational cohort study;Observational Study;Operations Research;participant enrollment;Pathway interactions;Patient Care;patient population;Patient Recruitments;Patients;Pattern;Peripheral;pharmacologic;Pharmacotherapy;Phenotype;Physiologic Monitoring;Physiological;Physiology;Plasma;Population;population based;Population Study;Positron-Emission Tomography;preservation;Principal Investigator;pro-brain natriuretic peptide (1-76);Program Evaluation;programs;Proteomics;Protocols documentation;public health relevance;recruit;Research;Research Infrastructure;Research Personnel;Rest;Sampling;screening;Signal Transduction;Site;Structure;Testing;Therapeutic Intervention;transcriptomics;Translating;unsupervised learning;Validation;wearable device;Woman

PROJECT_TITLE: Mass General Brigham HeartShare Clinical Center


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Social isolation is a major public health issue and a risk factor for morbidity and mortality comparable to smoking, hypertension, and a sedentary lifestyle. Human centered design and implementation science approaches can be utilized to identify and address social isolation among older adults living in subsidized housing.

PI_NAMEs: CUDJOE, THOMAS KOFI MENSAH (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: acceptability and feasibility;Address;Aging;American;attentional control;Baltimore;Basic Science;Behavioral Model;career development;Caring;Characteristics;Chronic;Cities;cohort;Communities;community advisory board;community engagement;community intervention;Complex;Control Groups;cost;Data;demographics;Epidemiology;experience;Exposure to;Foundations;Functional impairment;Funding;Future;General Population;Gerontology;Grant;Health;Home;Hospitalization;Housing;human centered design;Hypertension;Impaired health;implementation science;improved;Income;Individual;innovation;insight;Institutionalization;interest;Intervention;intervention delivery;intervention refinement;Investigation;Knowledge;Low income;Mediator;Medical;Medicare;Mental Health;Mentored Patient-Oriented Research Career Development Award;Methodology;Methods;Modality;Modification;Morbidity - disease rate;mortality;Needs Assessment;novel strategies;Nursing Homes;older adult;open label;Operative Surgical Procedures;Outcome;Participant;Patient Self-Report;peer;physical conditioning;Population;Populations at Risk;post intervention;Prevalence;Process;Protocols documentation;Public Health;Reporting;Research;research and development;Research Personnel;Research Support;Resources;Risk;Risk Factors;Savings;Scientist;sedentary lifestyle;Site;Smoking;social;social contact;social determinants;Social isolation;structural determinants;Structure;success;Surveys;Testing;therapy development;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: Identifying and Addressing Social Isolation among Older Adults Living in Subsidized Housing

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: WOODS HOLE

ORG_NAME: MARINE BIOLOGICAL LABORATORY

PHR: Trainees in neuroscience will be immersed in advanced training in neurobiology with a particular focus on cellular and molecular mechanisms that govern nervous system function in health and neurological disorders. This will create the leaders of the field by producing rigorous, fearless, and creative scientists, firmly committed to the strategic goals of NINDS.

PI_NAMEs: HYMAN, LINDA E (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Address;Area;Biological;Biological Models;Clinical;Creativeness;Data;Data Analyses;Data Set;design;Education;Educational process of instructing;Electrophysiology (science);empowerment;Equipment;experience;Experimental Designs;experimental study;Faculty;functional genomics;Funding;Future;Genetic;Goals;graduate student;Grant;grasp;hands on instruction;Health;Hour;Image;innovation;Instruction;International;Knowledge;Laboratories;Lead;Learning;lectures;marine;member;Mentors;Mentorship;Methodology;Modernization;Molecular;multidisciplinary;Names;National Institute of Neurological Disorders and Stroke;Nervous System;Nervous System Disorder;Nervous System Physiology;neural;Neurobiology;Neurological Models;Neurons;Neurosciences;Occupations;Participant;peer;peer networks;Peer Review;Postdoctoral Fellow;pre-doctoral;Professional Competence;programs;Ramp;Research;Research Personnel;Research Project Grants;Running;Scientist;Side;skills;statistics;Structure;Students;Technical Expertise;Techniques;Technology;technology platform;Training;Training Programs;unconscious bias;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: Neurobiology Summer Course


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cannabinoid Research;Chronic Pain;Endocannabinoid System Research;Headaches;Migraine;Neurosciences;Pain Research;Therapeutic Cannabinoid Research

ORG_CITY: HAYWARD

ORG_NAME: CALIFORNIA STATE UNIVERSITY HAYWARD

PHR: PROJECT NARRATIVE Existing anti-migraine agents produce unpleasant side effects, worsen headache with repeated use, and innovation in the development of new anti-migraine treatments with novel mechanisms of action has been minimal. To solve this problem, we developed new dual inhibitors of soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH) to increase the levels of anti-inflammatory and analgesic metabolites in headache- relevant regions of the body, and, in this proposal, we will conduct rigorous structure-activity relationship studies, biological evaluation, chemical optimization, and behavioral testing of our dual inhibitors. Through in vitro and in vivo studies, our studies will reveal the utility of inhibiting two pain-related enzymes and provide the first steps towards the discovery and validation of novel sEH/FAAH-based anti-migraine treatments for human.

PI_NAMEs: KANDASAMY, RAM  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Acids;Acute inflammatory pain;addiction;Adverse effects;allodynia;Analgesic Overuse Headaches;Analgesics;analog;anandamide;Anatomy;Anti-Inflammatory Agents;antinociception;Behavior;behavior test;Behavioral;behavioral pharmacology;benzothiazole;Binding;Biological;Biological Assay;Body Regions;Brain;Cannabinoids;Chemicals;clinical center;Clinical Pharmacology;Data;design;Development;Dose;Drug Design;drug discovery;Drug Interactions;Dura Mater;Endocannabinoids;Ensure;Enzyme Inhibitor Drugs;Enzymes;Epoxide hydrolase;Evaluation;exogenous cannabinoid;FAAH inhibitor;fatty acid amide hydrolase;Female;Foundations;functional restoration;Future;Gastric ulcer;Goals;Headache;Hispanic-serving Institution;Human;Hydrolase;Hyperalgesia;Hypersensitivity;improved;In Vitro;in vivo;in vivo evaluation;Inflammation;Inflammatory;inflammatory pain;inhibitor;innovation;Investigation;Ketoprofen;Lead;Libraries;Ligands;Link;Liver Microsomes;Location;male;medical schools;Mental Depression;Mentorship;Metabolic;Metabolic Pathway;Migraine;migraine treatment;Modeling;multidisciplinary;Nausea;Nervous System Disorder;Nitroglycerin;non-opioid analgesic;Non-Steroidal Anti-Inflammatory Agents;novel;Opioid;Pain;pain model;pain relief;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Play;pre-clinical;Prevalence;prevent;Property;Rattus;Recurrence;Resources;response;Rewards;Rodent;Rodent Model;Role;Running;sedative;Serotonin Agonists;side effect;single molecule;small molecule;Structure-Activity Relationship;success;Sumatriptan;Symptoms;synergism;System;targeted agent;Techniques;Testing;Tetrahydrocannabinol;Therapeutic;triptans;undergraduate student;Unilateral Headaches;Universities;Validation;Vomiting;Washington;Work

PROJECT_TITLE: Developing multitarget enzyme inhibitors as safe and effective anti-migraine treatments


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

PHR: Project Narrative This investigation aims to enhance understanding of the association between childhood economic conditions and both risk and protective factors for cardiovascular disease (CVD) in adulthood. Results of this study will inform prevention and intervention efforts aimed at reducing CVD risk, by delineating childhood exposures that increase and buffer adult cardiometabolic health risk. Moreover, by testing novel contextual pathways at the family, school, and neighborhood levels this investigation will help to identify contexts that can be targeted by programs and policies to reduce socioeconomic disparities in adult health.

PI_NAMEs: MARSLAND, ANNA L (contact);SHAW, DANIEL S;VOTRUBA-DRZAL, ELIZABETH

PROGRAM_OFFICER_NAME: JAQUISH, CASHELL E

PROJECT_TERMS: Address;Adolescence;Adult;Age;aged;Attenuated;Biological Markers;Blood Pressure;boys;Buffers;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;carotid intima-media thickness;Cause of Death;Child;Childhood;Chronic Disease;Communities;community-level factor;Development;Diabetes Mellitus;Disadvantaged;Disease;disorder risk;Disparity;Dyslipidemias;early childhood;Economic Conditions;economic disparity;emerging adult;Epidemiology;experience;Family;Growth;Health;Health behavior;health disparity;high risk;Immunologic Factors;improved;Income;Individual;Informal Social Control;informant;Insulin Resistance;intergenerational;Intervention;intervention program;Investigation;Knowledge;Life;Link;longitudinal, prospective study;Low income;low socioeconomic status;lower income families;Mediating;men;Metabolic Pathway;Methods;middle childhood;Mothers;Neighborhoods;novel;Obesity;Outcome;parent project;Pathogenesis;Pathway interactions;Phase;physical conditioning;Physiologic pulse;Policies;Poverty;pre-clinical;prevent;Prevention;Prevention program;Process;programs;prospective;Prospective Studies;protective factors;Race;recruit;Reporting;Research;resilience;resilience factor;Risk;Risk Assessment;Risk Factors;Role;Sampling;Schools;Shapes;socioeconomic adversity;socioeconomic disadvantage;socioeconomic disparity;socioeconomics;stem;Stress;systemic inflammatory response;teacher;Testing;Toddler;transmission process;Woman;young man

PROJECT_TITLE: Childhood Antecedents of Adult Cardiometabolic health: A Prospective Study of Low-Income Men


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE This is a broadly based predoctoral training program in Neuroscience with the objective of providing individualized, high quality training to predoctoral students interested in pursuing scientific careers in the biological and biomedical sciences. The program includes a focused emphasis on training in quantitative thinking and experimental design and analysis and would support students in their first two years of graduate studies, before they start their dissertation research. We request 8 predoctoral training slots for students in their first two years of our program.

PI_NAMEs: LIPSCOMBE, DIANE ;SHEINBERG, DAVID L (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TITLE: Interdisciplinary Predoctoral Neuroscience Training Program in the Neuroscience Graduate Program.


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

PHR: PROJECT NARRATIVE  While autism spectrum disorder (ASD) is common and impairing, our lack of knowledge about the mechanisms underlying co-occurring depression in people with ASD hinders clinical care and effective treatments. This K23 seeks to address this gap, defining brain mechanisms associated with depressive symptoms in adolescents with ASD compared to controls, leveraging multimodal imaging methods (resting- state functional magnetic resonance imaging, diffusion spectrum imaging, and myelin imaging). This work is significant because it will create the foundation for future studies defining how the brain mechanisms of co- occurring depressive disorders in individuals with ASD change across development, and, ultimately, to develop novel brain-targeted treatments for depression in people with ASD.

PI_NAMEs: RADOEVA, PETYA D (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Address;Adolescent;adolescent with autism spectrum disorder;Age;Amygdaloid structure;Anterior;Architecture;autism spectrum disorder;autism symptoms;autistic children;Brain;career;career development;Caring;Child;cingulate cortex;Clinical;clinical care;comparison control;connectome;corpus callosum body;Data;Depressive disorder;depressive symptoms;Development;Diagnosis;Diagnostic;Diffusion;Doctor of Medicine;Doctor of Philosophy;early childhood;effective therapy;Evaluation;Foundations;Functional Magnetic Resonance Imaging;Future;Goals;Image;imaging modality;Impairment;improved;individuals with autism spectrum disorder;innovation;Insula of Reil;Knowledge;Life;life time cost;Link;Literature;Major Depressive Disorder;Mental Depression;Mental disorders;Methodology;Methods;Modality;Mood Disorders;Multimodal Imaging;Myelin;myelination;National Institute of Mental Health;neural;neural circuit;neural network;neuroimaging;neuromechanism;novel;Patients;Phenotype;Physicians;precision medicine;Prefrontal Cortex;Psychopathology;Research;Research Personnel;Rest;Sampling;Scanning;Scientist;Severities;sex;spectrograph;Strategic Planning;Structure;symptom treatment;Symptoms;Teenagers;Testing;Thalamic structure;thalamocortical tract;therapy development;Translating;translational approach;white matter;Work;Writing;young adult

PROJECT_TITLE: Neural Mechanisms of Depressive Symptoms in Youth with Autism SpectrumDisorder

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Patient Safety

ORG_CITY: Fairfax

ORG_NAME: INOVA HEALTH CARE SERVICES

PHR: PROJECT NARRATIVE More than two-thirds of older adults are living with symptomatic cardiovascular disease. Many live with undiagnosed geriatric syndromes including phenotypic frailty and lack of physical resilience. This research proposal will enhance our understanding of the influence of geriatric syndromes on health outcomes, disability, and health-related quality of life among older adults with acute myocardial infarction.

PI_NAMEs: DAMLUJI, ABDULLA AL (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Acute;Acute myocardial infarction;Address;Admission activity;Adult;adverse outcome;Advocate;Age;age effect;Age Years;Anemia;Award;Back;beneficiary;Benefits and Risks;Binding;Bioinformatics;Biometry;Blood flow;Blood Vessels;Capsicum;Cardiology;Cardiovascular Diseases;Cardiovascular system;care outcomes;career;Caring;clinical decision-making;Clinical effectiveness;clinical investigation;Clinical Trials;comparative effectiveness;Coronary;Coronary Artery Bypass;Coronary heart disease;Data Collection;Decision Making;design;Development;diagnostic accuracy;diagnostic tool;disability;Disease;education research;Educational workshop;Elderly;Environment;Epidemiologist;Evaluation;evidence base;experience;Experimental Designs;Exposure to;follow-up;Foundations;Frail Elderly;frailty;Geriatrics;Gerontology;Goals;Grant;Guidelines;Health;health related quality of life;Heart;Heterogeneity;High Prevalence;Hospitalization;Hypoalbuminemia;Impaired cognition;Impairment;improved;indexing;Institution;Internist;Intervention;Knowledge;Laboratories;Learning;Lower Extremity;Measurement;Measures;Medical;Medical Libraries;Medicare;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;mortality;Office Management;older adult;older patient;Older Population;Operative Surgical Procedures;Outcome;Outcomes Research;Patient Admission;patient population;Patient-Focused Outcomes;Patients;percutaneous coronary intervention;Phenotype;Physicians;Physiological;Population;Prevalence;Procedures;Process;Prospective Studies;Public Health Schools;Research;Research Personnel;Research Proposals;resilience;Resistance;Resources;Retrospective cohort study;revascularization;Risk;Role;Sampling;skills;standard of care;stressor;Syndrome;targeted treatment;Testing;Time;Training Programs;treatment choice;treatment response;United States;United States National Institutes of Health;Universities;Work;young adult

PROJECT_TITLE: Frailty and Resiliency in Older Adults with Acute Myocardial Infarction

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Prevention;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative The goal of this proposal is to comprehensively test and compare the immunogenicity and protection efficacy of four Severe fever with thrombocytopenia syndrome virus (SFTSV)-specific vaccine candidates against lethal SFTSV infection in age-dependent ferret model.

PI_NAMEs: JUNG, JAE U (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: 4 year old;Age;age group;age related;aged;Antibody Response;Asia;Attenuated;Attenuated Vaccines;Basic Science;Biochemical;Cells;Characteristics;Clinical;clinical diagnosis;clinically relevant;CNR1 gene;Communicable Diseases;comparative;Dangerousness;Death Rate;Disease Outbreaks;DNA;DNA Vaccines;Epidemic;Family;Far East;Ferrets;Ferritin;Fever;Future;gene function;Genes;Genetic;Genome;Genotype;Genus Phlebovirus;Glycoproteins;Goals;Head;Hemorrhage;Host Defense;Human;IFNAR1 gene;Immune;Immune Evasion;Immunity;Immunocompetent;immunogenicity;Immunologics;in vivo;Incidence;Infection;insight;Interleukin-10;MAP3K8 gene;member;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mutant;nanobiotechnology;nanoparticle;neutralizing antibody;older patient;outbreak concern;Pathogenesis;pathogenic virus;Pathogenicity;Pathway interactions;Patients;Persons;Phosphotransferases;Production;protective efficacy;Proteins;Recombinant Proteins;recombinant virus;Recombinants;reverse genetics;Risk Factors;RNA;RNA-Directed RNA Polymerase;Seroprevalences;Severe Fever with Thrombocytopenia Syndrome Virus;Source;Surface;Symptoms;Syndrome;System;T cell response;Testing;Thrombocytopenia;tick-borne;Ticks;Time;tool;Vaccination;vaccine candidate;Vaccine Design;vaccine development;vaccine efficacy;Vaccines;vector vaccine;Vesicular stomatitis Indiana virus;Viral;Viral Genome;Viral Hemorrhagic Fevers;Viral Pathogenesis;Viral Proteins;Virion;Virus;Virus Diseases;Virus Replication;virus testing

PROJECT_TITLE: Tickborne SFTS Virus Vaccine Development


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: ALLEN INSTITUTE

ORG_STATE: WA

PHR: Specific neuron subtypes in the primate neocortex are implicated in neurodegenerative disorders. These neurons express unique complements of ion channels and neuromodulator receptors in primates. In this fundamental research project, we test the consequences of the cell type-specific expression of these genes on neuronal input-output properties in key brain regions in both human and non-human primates.

PI_NAMEs: DEMBROW, NIKOLAI C;KALMBACH, BRIAN E. (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Area;Axon;Behavior;Brain;Brain Diseases;Brain region;Categories;cell type;Cells;Closure by clamp;Collection;Data;Development;Disease;disease model;Disparate;Etiology;excitatory neuron;Exhibits;experimental study;Family;Functional disorder;fundamental research;Future;Gene Expression;Genes;Genetic;Goals;Health;hippocampal pyramidal neuron;Human;in vivo;Ion Channel;Ion Channel Gating;Knowledge;Label;Molecular Profiling;Monkeys;Morphology;Motor Cortex;Motor Neurons;mRNA Expression;multimodality;Mus;Neocortex;neocortical;Nervous System Disorder;Neurodegenerative Disorders;Neuromodulator;Neuromodulator Receptors;Neurons;neuroregulation;nonhuman primate;Norepinephrine;novel;Operative Surgical Procedures;Output;patch clamp;patch sequencing;Patch-Clamp Techniques;Pathologic;Pattern;Pharmacological Treatment;Phenotype;Physiological;Physiology;Population;Primates;Property;prospective;Publishing;receptor;Receptor Gene;Research Project Grants;response;Rodent;Rodent Model;segregation;Serotonin;Shapes;Slice;species difference;Specimen;Structure;Techniques;Telencephalon;Temporal Lobe;Testing;Tissues;tool;transcriptomics;Translating;Viral;Viral Vector;voltage;Work

PROJECT_TITLE: Multimodal analysis of primate infragranular pyramidal neurons and their modulation

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


ORG_CITY: Rio de Janeiro

ORG_COUNTRY: BRAZIL

ORG_FIPS: BR

ORG_NAME: FUNDACAO OSWALDO CRUZ

PHR: PROJECT NARRATIVE Fungal diseases are a major threat to human health, and cryptococcosis, caused by Cryptococcus, kills nearly 200,000 people each year. This program will take a multidisciplinary approach to define the effects of a small peptide molecule produced by Cryptococcus and its target enzyme on the outcomes of this lethal fungal infection with the intent of developing insights on the infection process and to develop novel treatments to fight the disease.

PI_NAMEs: NOSANCHUK, JOSHUA D;RODRIGUES, MARCIO LOURENCO (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Affect;Animal Model;anti-fungal agents;Antigens;cellular targeting;Cessation of life;Classification;Collaborations;Complex;cost;Cryptococcosis;Cryptococcus;Cryptococcus gattii;Cryptococcus neoformans;Dipeptidyl Peptidases;Disease;Disease Progression;effective therapy;Enzymes;extracellular vesicles;Face;fighting;Fostering;Funding;Fungal Vaccines;fungus;Glucose;glucose metabolism;Growth;Health;Human;immune activation;Immune response;Immunity;Immunocompromised Host;Immunologics;Individual;Infection;inhibitor;insight;Institution;Insulin;interdisciplinary approach;invertebrate host;Investigation;Isoleucine;Laboratories;Left;Macrophage;member;Meningoencephalitis;Methods;Modeling;Molecular;Mus;Mycoses;Natural Immunity;neglect;novel;Outcome;Pathogenesis;pathogenic fungus;Pathogenicity;Peptides;Peptidyl-Dipeptidase A;Persons;Phagocytes;Physiology;Play;Population;Preparation;prevent;Prevention;Process;programs;Proline;prophylactic;protective effect;Public Health;Publishing;Regulation;Research;response;Risk;RNA vaccine;Role;single molecule;small molecule;Testing;Therapeutic;Toxic effect;vaccine candidate;Vaccines;Virulence;Work;World Health Organization

PROJECT_TITLE: An extracellular vesicle component as a candidate to control cryptococcosis.

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SAS-W (J1)]


ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE The M4I: Maryland Infection, Immunization, Intervention, and Impact Training Program provides structured training and robust mentorship to inspire and prepare the next generation of infectious disease researchers. We will enroll a diverse group of medical students to establish a cohort of trainees who will participate in formal research training and develop a hypothesis-driven research project with the support of their faculty mentors, methodological experts, and their peers. They will continue to work together as a longitudinal research track cohort for their medical school career, with opportunities to receive additional funding for research electives or an MD/Master’s dual degree program.

PI_NAMEs: LAUFER, MIRIAM K. (contact);RIEDEL, DAVID J

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Area;career;career development;clinical care;Clinical Research;cohort;Communicable Diseases;Communication;cost;Data;Data Analyses;Dedications;Degree program;Development;diversity and inclusion;education research;Educational workshop;Eligibility Determination;Enrollment;Ensure;Environment;equity, diversity, and inclusion;experience;Exposure to;faculty mentor;Feedback;Funding;Genomics;global health;Goals;Grant;HIV;Immunization;Infection;Infectious Diseases Research;International;Intervention;Laboratories;Lead;Maryland;medical schools;Medical Students;Mentors;Mentorship;Methodology;Modeling;Monitor;next generation;peer;Peer Review;Physicians;Program Evaluation;programs;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Research Training;Science;skill acquisition;skills;Standardization;Structure;student participation;Students;Time;Training;Training Programs;undergraduate medical education;Universities;vaccine development;Work

PROJECT_TITLE: Maryland Infection, Immunization, Intervention, and Impact (M4I) Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 PP-D (M1)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative This project aims to build a more comprehensive understanding of the genetic architecture of Alzheimer's Disease and related dementias, taking into account the complexities of age-related changes and diverse phenotypes. By leveraging large-scale biobanks, electronic medical records, and innovative machine learning techniques, we hope to uncover crucial insights that could lead to better understanding of disease progression, improved prevention strategies and novel therapeutic targets, representing a signiﬁcant advancement in dementia research.

PI_NAMEs: IONITA, IULIANA ;LIU, MOLEI ;WEI, YING  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Address;Affect;Age;age related;age related changes;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;analytical method;analytical tool;Area;biobank;Biological;Blood Vessels;comorbidity;Complex;Computerized Medical Record;Data;data fusion;data imputation;data resource;deep learning;Dementia;Dependence;design;Detection;Development;Disease;Disease Progression;DNA;early onset;effective therapy;Ensure;Gene Expression;Genetic;genetic architecture;Genetic Diseases;Genetic Structures;Genetic study;genetic variant;genome wide association study;genome-wide;Genotype;Goals;Heritability;Heterogeneity;high dimensionality;Immune system;improved;Individual;innovation;insight;Knowledge;Late Onset Alzheimer Disease;learning algorithm;Life;Life Cycle Stages;life span;Link;Machine Learning;Metabolic;Methodology;Methods;Modeling;Motivation;Network-based;neural network;Neurodegenerative Disorders;new therapeutic target;novel;Pathway interactions;Persons;phenome;Phenotype;phenotyping algorithm;Physiological;Population;Population Heterogeneity;Prevention strategy;Process;Records;Research;Research Design;statistical learning;supervised learning;Susceptibility Gene;Techniques;Therapeutic Intervention;therapeutic target;Time;tool;treatment strategy;two-dimensional;Validation;Variant

PROJECT_TITLE: Statistical Framework for Unraveling Age-Dependent Genetic Landscape of Alzheimer's Disease and Related Dementias: Harnessing Large-Scale EHR and DNA-Biobank Integration

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: OVERALL: PROJECT NARRATIVE The Population Studies Center (PSC) at the U. of Pennsylvania provides critical infrastructure to generate innovative, interdisciplinary research on the economic, social, and environmental dimensions of population growth and structure that are central to health and well-being. The research supported by this award will inform the design of policies and interventions aimed at improving overall health and reducing health disparities.

PI_NAMEs: PARRADO, EMILIO ALBERTO (contact)

PROGRAM_OFFICER_NAME: CLARK, REBECCA L

PROJECT_TERMS: Address;Area;Award;base;behavioral and social science;Big Data;career;Child Development;Child Mortality;Classification;Communities;community center;Computing Methodologies;COVID-19 impact;COVID-19 pandemic effects;Data;Data Sources;Demography;design;Development;Dimensions;Economics;Endowment;Environment;environmental change;Ethnic Origin;Evolution;experience;Faculty;Family;Fertility;Fostering;frontier;Funding;Gender;Generations;global health;Goals;Grant;Health;Human;Human Development;Human Resources;improved;Individual;Inequality;Information Technology;Infrastructure;innovation;Institution;interdisciplinary approach;Interdisciplinary Study;Internal Migrations;International;International Migrations;international partnership;Intervention;Leadership;Life Cycle Stages;Mentors;Methods;mid-career faculty;mortality;National Institute of Child Health and Human Development;Nerve;outreach;Pennsylvania;Personal Satisfaction;Policies;Population;Population Dynamics;Population Growth;Population Heterogeneity;Population Research;Population Sciences;Population Study;Postdoctoral Fellow;Production;programs;R24;Race;recruit;Reduce health disparities;Reproductive Health;Research;Research Support;Resource Sharing;Resources;Scientist;Services;Sexually Transmitted Diseases;social;Social Mobility;Structure;success;Techniques;Time;Training;United States;Universities;Urbanization

PROJECT_TITLE: Population Dynamics Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-K (55)]


NIH_SPENDING_CATS: Social Determinants of Health

PROJECT_TERMS: Administrative Coordination;Award;career;community building;cost effectiveness;Development;Ensure;Environment;Exposure to;Extramural Activities;flexibility;Fostering;Foundations;Funding;Funding Agency;Grant;Infrastructure;Instruction;interdisciplinary collaboration;Leadership;Mission;Nerve;notch protein;Policies;Population;Population Dynamics;Population Research;Procedures;Research;Research Personnel;Research Project Grants;Resource Allocation;Resources;Scientist;Services;success;Time;timeline;Training;United States National Institutes of Health;Universities


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Social Determinants of Health

PI_NAMEs: FOMBY, PAULA W (contact)

PROJECT_TERMS: Address;aging population;Area;behavioral economics;career;Child Development;cognitive development;Collaborations;Communities;data centers;Dedications;Demography;Development;Education;Educational workshop;Endowment;Environment;environmental change;Ethnic Origin;Event;Fertility;Financial Support;Fostering;Funding;Gerontology;Goals;Grant;Growth;Health;Human;Inequality;innovation;Interdisciplinary Study;Internal Migrations;International;International Migrations;Life Cycle Stages;Link;Mentors;Methods;mid-career faculty;Mission;mortality;next generation;outreach;Peer Review;Personal Satisfaction;Philadelphia;Population;Population Dynamics;Population Heterogeneity;Population Research;Population Sciences;Population Study;Postdoctoral Fellow;Production;Productivity;Program Evaluation;programs;Public Policy;Race;recruit;Reproductive Health;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Scientist;Services;Social Mobility;Source;Structure;symposium;Universities;Urbanization;Writing


NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SONG, XI  (contact)

PROJECT_TERMS: Address;Adoption;Big Data;Biological Markers;career;cluster computing;Collaborations;Communication;Communities;Computing Methodologies;computing resources;Data;data access;Data Collection;data enclave;Data Science;data sharing;Data Sources;Data Storage and Retrieval;Demography;Educational workshop;empowerment;experience;Fostering;Funding;Genetic;Grant;High Performance Computing;Information Technology;Infrastructure;innovation;Java;Measures;Methodology;Methods;mid-career faculty;Mission;Operating System;Population;Population Dynamics;population health;Population Research;Population Sciences;Postdoctoral Fellow;Programming Languages;programs;Protocols documentation;Pythons;Research;Research Personnel;Resource Sharing;Resources;Science;Scientist;Secure;Services;Shapes;Social Sciences;software systems;Statistical Data Interpretation;summer institute;Surveys;Technology;tool;Training;Work


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cardiovascular;Comparative Effectiveness Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Orphan Drug;Pediatric;Rare Diseases;Regenerative Medicine;Transplantation

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PUBLIC HEALTH NARRATIVE Congenital cardiac anomalies represent the most common birth defect, affecting nearly 1% of all live births and despite significant advances in their surgical and medical management, these conditions remain a leading cause of death and disability in the newborn period. One significant source of morbidity and mortality arises from complications associated with the use of currently available prosthetic vascular grafts, cardiovascular patches, and replacement heart valves that are frequently required to perform reconstructive procedures. Tissue engineering offers a potential strategy for creating improved biomaterials for use in congenital heart surgery.

PI_NAMEs: BREUER, CHRISTOPHER KANE (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: 3-Dimensional;4D MRI;Acetylcholine;Adolescent;Affect;Age;Angiography;Animal Model;Animals;Autologous;Biocompatible Materials;Blood flow;Blood Vessel Prosthesis;Blood Vessels;calcification;Cardiac;Cardiovascular system;Caring;Cause of Death;Characteristics;Child;Cine Magnetic Resonance Imaging;Clinic;Clinical;Clinical Trials;cohort;Common Ventricle;comparative efficacy;Congenital Abnormality;congenital heart abnormality;Congenital Heart Surgery;Coupled;Data;design;Development;Devices;disability;Disease;Dobutamine;Dose;Electric Capacitance;Fontan Procedure;Functional Regeneration;Geometry;Goals;Grant;Growth;heart valve replacement;Heart Ventricle;hemodynamics;Image;Implant;implantation;improved;improved outcome;in vivo;Inferior vena cava structure;Investigation;life span;Liquid substance;Live Birth;Measures;Medical;Modeling;Monitor;Morbidity - disease rate;morphometry;mortality;Natural regeneration;Newborn Infant;Nitroglycerin;Norepinephrine;operation;Operative Surgical Procedures;Orphan;parent project;Performance;pharmacologic;Physiological;Polytetrafluoroethylene;Postoperative Complications;pre-clinical;preclinical study;pressure;prevent;Procedures;Property;Prosthesis;Public Health;Pulmonary artery structure;Reagent;Regulatory Pathway;repaired;Resistance;respiratory;response;Rest;Risk;Safety;scaffold;sex;Sheep;sheep model;Source;standard of care;Stress;Stress Tests;Technology;Testing;Time;Tissue Engineering;Tissues;Translating;ultrasound;Vascular Graft;vascular tissue engineering;vasoconstriction;Vasodilation;Ventricular Function;Work;X-Ray Computed Tomography

PROJECT_TITLE: A preclinical study evaluating and comparing the efficacy of tissue engineered vascular grafts to polytetrafluoroethylene grafts - DIVERSITY SUPP VILLARREAL


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;HIV/AIDS;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: NEW ORLEANS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PUBLIC HEALTH RELEVANCE/PROJECT NARRATIVE Oropharyngeal squamous cell carcinoma (OPSCC) caused by human papillomavirus (HPV) is an extremely important public health problem with increasing incidence, especially in human immunodeficiency virus (HIV)-infected individuals. However, the role that HIV immunosuppression plays in the development of HPV-OPSCCs is poorly understood, and currently, there is no animal model for HPV-induced oral infections and malignancies in the context of HIV-induced immunosuppression. The studies we propose will characterize and establish a needed rhesus macaque model of persistent oral HPV and HIV co-infection using Macaca mulatta papillomavirus type 1 (MmPV1) and simian immunodeficiency virus (SIV) that will be foundational for future research into the mechanisms of oral MmPV1 infections, persistence, precancer, and OPSCC induction.

PI_NAMEs: DATTA, PRASUN K;TRAINA-DORGE, VICKI L (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Anatomy;Animal Model;Animals;Anogenital cancer;antiretroviral therapy;Autopsy;Biological;Biological Assay;cancer risk;carcinogenesis;carcinogenicity;CDKN2A gene;Cells;Cervical;chemokine;co-infection;cofactor;Country;cytokine;Data;Development;Diagnosis;Disease;Disease Progression;DNA;Epidemiology;experience;Exposure to;Female;Follow-Up Studies;Genome;Genotype;Head and Neck Cancer;Histologic;HIV;HIV Seronegativity;HPV positive;Human;Human papilloma virus infection;Human Papillomavirus;Human papillomavirus 16;Immunoassay;Immunocompetent;Immunocompromised Host;immunodeficiency;Immunohistochemistry;Immunology;immunosuppressed;Immunosuppression;In Vitro;Incidence;Income;Individual;Infection;innovation;Knowledge;Lesion;Longitudinal Studies;Macaca mulatta;male;Malignant Neoplasms;malignant oropharynx neoplasm;Malignant Squamous Cell Neoplasm;MAPK3 gene;Measures;Meta-Analysis;Modeling;Names;Neoplasms;neoplastic;nonhuman primate;Oncogenic;Oral;oral HIV;oral HPV;oral HPV infection;oral infection;Oropharyngeal;Oropharyngeal Squamous Cell Carcinoma;Palatine Tonsil;Papillomavirus;Pathogenesis;Pathology;Pathway interactions;Penis carcinoma;Persons;Phosphorylation;Phylogenetic Analysis;Physiological;Plasma;Play;Population;potential biomarker;premalignant;Prevalence;prevent;prognostic assays;Prognostic Marker;Public Health;public health relevance;Rhesus;Risk;Role;Saliva;Sampling;screening;Sexually Transmitted Diseases;Site;SIV;Soft Palate;Squamous Cell;synergism;systematic review;Testing;Therapeutic;Time;time interval;Tissues;tongue root;Tonsil;transmission process;tumor;Tumor Burden;tumor progression;tumorigenesis;viral DNA;Viral Genome;Viral Load result;Virion;Virus;Virus Diseases;virus host interaction;Virus Shedding;Work;young man

PROJECT_TITLE: Development of a Rhesus Macaque Model of Persistent Oral HPV and HIV Co-infection to Study Oropharyngeal Cancer Induction

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 CC (10)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Rehabilitation

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Primary care clinicians are rarely part of the multi-disciplinary survivorship care delivered by oncology teams, despite National Comprehensive Cancer Network guidelines and National Academy of Medicine reports recommending that cancer survivors stay connected with their primary care clinicians. Leveraging our team’s program of research in primary care and cancer survivorship care delivery, we will conduct a pragmatic trial testing implementation and effectiveness of a survivorship care delivery intervention among eight Community Health Center sites across Texas. Guided by theory-based conceptual models to maximize the likelihood of successful implementation and sustainment within each local context, our evaluation will generate rich and actionable lessons to scale this generalist primary care-based care delivery model to improve cancer survivorship care equitably.

PI_NAMEs: BALASUBRAMANIAN, BIJAL A. (contact);LEE, SIMON J. CRADDOCK

PROGRAM_OFFICER_NAME: ETON, DAVID T

PROJECT_TERMS: Academy;Address;Adherence;Adoption;Attention;Breast;Cancer Center;cancer recurrence;Cancer Survivor;cancer survivorship care;cancer therapy;cancer type;Cardiology;cardiovascular risk factor;care coordination;care delivery;Caring;Chronic;Clinic;Clinical;Cluster randomized trial;Colorectal;Communication;Communities;Community Health;Comprehensive Health Care;cost effectiveness;Diagnosis;Disease;Effectiveness;Effectiveness of Interventions;effectiveness testing;Equity;Evaluation;evidence base;Evidence based intervention;experience;General Practitioners;Goals;Guidelines;Health;Health system;Healthcare;implementation evaluation;implementation intervention;implementation strategy;improved;intervention delivery;Knowledge;Lung;Malignant Neoplasms;Medicine;Methods;Modeling;multidisciplinary;National Comprehensive Cancer Network;Neighborhood Health Center;Oncology;Outcome;Patients;Persons;poor health outcome;Practical Robust Implementation and Sustainability Model;pragmatic trial;Primary Care;primary care clinician;primary care setting;primary care team;primary care visit;primary outcome;Privatization;programs;Prostate;provider to provider;Recommendation;Recording of previous events;Reporting;Research;safety net;scale up;screening guidelines;Second Primary Cancers;secondary outcome;Service delivery model;Site;surveillance network;Survivors;survivorship;System;Testing;Texas;theories;Training;trial design;tv watching;Uninsured

PROJECT_TITLE: Enhancing Primary Care Capacity for Cancer Survivorship Care Delivery in Community Health Clinics

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (J1)]