NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Underage Drinking

ORG_DEPT: FAMILY MEDICINE

PHR: Project Narrative Young adults under criminal justice supervision are at an increased risk for development of substance use disorders; however, there is limited understanding of the real-time contextual, psychological, and behavioral antecedents of substance use in vulnerable young adults. This project will test the momentary psychological, behavioral, and geospatial risk for substance use in young adults enrolled in drug treatment court (DTC) by integrating geographically-explicit ecological momentary assessment (GEMA) data with risk terrain modeling (RTM). This project will develop a novel just-in-time adaptive intervention (JITAI) to reduce substance use in young adult DTC clients.

PI_NAMEs: GAJOS, JAMIE  (contact)

PROGRAM_OFFICER_NAME: MULFORD, CARRIE FRIED

PROJECT_TERMS: adaptive intervention;Address;Adult;Affect;Affective;Age;aged;alcohol consequences;Alcohol consumption;alcohol outlet density;Alcohols;Assessment tool;Behavior;Behavioral;behavioral health;built environment;career;career development;Cellular Phone;Client;Clinical;Communities;court;craving;Crime;Criminal Justice;Data;design;Development;Development Plans;Discrimination;Disease;Diversion Program;Drug usage;Drug user;Ecological momentary assessment;effective intervention;emerging adulthood;Enrollment;Environment;environmental stressor;Ethnic Origin;experience;Exposure to;Foundations;Frequencies;Funding;Future;General Population;geographic risk;Geography;Goals;Health;high risk population;Homeless persons;Homelessness;implementation intervention;Individual;individualized medicine;innovation;Interdisciplinary Study;Intervention;Investigation;Justice;Knowledge;Life;Life Cycle Stages;Location;longitudinal design;Mental Health;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Methods;mHealth;mhealth interventions;Modeling;Moods;Movement;National Institute of Drug Abuse;neighborhood disadvantage;Neighborhoods;novel;Outcome;Perception;Persons;Pharmaceutical Preparations;Pharmacotherapy;physical conditioning;pilot test;polysubstance use;Population;Process;programs;psychologic;Psychopathology;Psychosocial Factor;Race;recidivism;recruit;reduced substance use;Reporting;Research;research and development;Resources;Risk;Risk Assessment;Risk Behaviors;Sampling;secondary analysis;sex variable;skills;Social Environment;societal costs;Stress;stressor;Subgroup;substance use;Substance Use Disorder;substance use prevention;substance user;Supervision;Surveys;System;Testing;Time;time use;Tobacco;Training;Variant;Violence;Visit;Vulnerable Populations;young adult

PROJECT_TITLE: Momentary Geospatial, Psychological, and Behavioral Risk for Substance Use in Young Adults Under Criminal Justice Supervision

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Childhood Obesity;Clinical Research;Dementia;Diabetes;Neurodegenerative;Neurosciences;Nutrition;Obesity;Pediatric;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CINCINNATI

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE  Type 2 diabetes, even in adolescents, leads to damage to blood vessels that plausibly extends to the brain. Using advanced imaging methods, this project will comprehensively determine how the structure and function of blood vessels in the brain are impaired by type 2 diabetes and how that might lead to tissue loss and cognitive problems in teens. This new knowledge will drive optimal design of treatment approaches to prevent or reverse brain complications due to diabetes in adolescents that could otherwise extend to adulthood.

PI_NAMEs: DI FRANCESCO, MARK WILLIAM;SHAH, AMY SANGHAVI (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Adolescent;Adult;Age;arterial spin labeling;Blood Pressure;Blood Vessels;blood-brain barrier permeabilization;Body mass index;Body Weight decreased;Brain;brain abnormalities;brain behavior;brain dysfunction;brain health;brain tissue;brain volume;Caring;cerebrovascular;Cerebrovascular Circulation;cerebrovascular health;cerebrovascular reactivity;Cerebrovascular system;Clinical;Cognition;Cognitive;cognitive performance;cohort;Collaborations;Control Groups;critical period;daily functioning;Data;Development;Diabetes Mellitus;Disease;Exercise;experience;Eye;Foundations;glycemic control;Glycosylated hemoglobin A;gray matter;Heart;imaging biomarker;imaging modality;Impaired cognition;Impairment;improved;improved outcome;Intervention;Kidney;Knowledge;Laboratories;Lipids;Magnetic Resonance Imaging;Measures;member;Methods;modifiable risk;Monitor;Morbidity - disease rate;Morphology;mortality;Neuroanatomy;Neurocognition;Neurocognitive;Neurocognitive Deficit;Neuroglia;neuroimaging;Neurons;neurovascular unit;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;non-invasive imaging;Obesity;Outcome;participant retention;peer;Physiological;Plasma;Population;Positioning Attribute;premature;prevent;Property;Race;rate of change;recruit;Reporting;Research;research study;Risk Factors;sex;Short-Term Memory;Structure;Systemic Lupus Erythematosus;Teenagers;Testing;therapy design;Thinness;Time;Tissues;Unit of Measure;Vascular Diseases;vascular risk factor;Youth

PROJECT_TITLE: Understanding the Impact of Youth Onset Obesity and Type 2 Diabetes on the Neurovascular Unit

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Desmoids are a rare and poorly understood type of tumor with outcomes that are highly variable, leaving patients and physicians uncertain about how aggressively the individual patient's treatment should be. We propose to pursue the hypothesis, suggested by our prior research, that proteins called β-catenin and HIF1α are central to the biology of desmoids. By discovering which other proteins act with β-catenin and HIF1α and testing whether these proteins are correlated with disease progression in patients with desmoids, we expect to discover markers that can predict patients' outcomes and that may allow for better decisions on whether a patient requires therapeutic intervention.

PI_NAMEs: CRAGO, AIMEE MARIE (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Abdomen;Adriamycin PFS;Adult;adverse event risk;Affect;Aggressive Fibromatosis;alpha catenin;BAY 54-9085;Benefits and Risks;beta catenin;Binding;Biological Markers;Biology;biomarker identification;Biopsy Specimen;CCND1 gene;Cell Proliferation;Cells;Cessation of life;Characteristics;Clinical;Contracture;Counseling;CTNNB1 gene;Data;Disease;Disease Progression;DNA Sequence Alteration;druggable target;gene product;Genes;genetic analysis;Growth;HIF1A gene;Hypoxia Inducible Factor;Immunohistochemistry;In Vitro;Individual;individual patient;inhibitor;insight;Intestines;knock-down;Ligands;Limb structure;Link;Malignant Neoplasms;Mediating;Mesenchymal Cell Neoplasm;middle age;Molecular;Morbidity - disease rate;Mutation;Neoplasm Metastasis;Neoplasms;new therapeutic target;Oncogenic;Operative Surgical Procedures;Outcome;outcome prediction;overexpression;Pain;Pathway interactions;patient prognosis;patient subsets;Patient-Focused Outcomes;Patients;phase II trial;Physicians;Platelet-Derived Growth Factor;platelet-derived growth factor BB;potential biomarker;predictive marker;Progression-Free Survivals;Proliferating;Proteins;Receptor Protein-Tyrosine Kinases;Recommendation;Recurrence;Regimen;Reproducibility;Research;Role;Signal Pathway;Signal Transduction;standard care;Symptoms;Systemic Therapy;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;tool;Transcriptional Regulation;tumor;tumor growth;tumorigenesis;Variant;Widespread Disease;Work

PROJECT_TITLE: Investigating HIF1-alpha Signaling to Identify Predictive Markers and Therapeutic Targets in Desmoid-Type Fibromatosis

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative The participation of clinician-scientists in the biomedical research enterprise helps bridge the gap between basic science and clinical practice. Intensive, mentored clinical training provided through the NIDA Mentored Clinical Scientists Development Program in Drug Abuse and Addiction (NIDA K12) at MUSC helps ensure that there is a diverse pool of highly trained clinician-scientists available to address the Nation’s critical health care needs.

PI_NAMEs: GRAY, KEVIN M;MCRAE-CLARK, AIMEE L (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: addiction;Address;Area;career;career development;Clinical;Clinical Research;clinical training;Drug abuse;Drug Addiction;Educational Status;Ensure;Entrepreneurship;experience;Faculty;Funding;Health;health disparity;Healthcare;Individual;Infrastructure;innovation;leadership development;Medical;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Mission;National Institute of Drug Abuse;opioid use disorder;Positioning Attribute;Program Development;programs;recruit;Request for Applications;Research;Research Personnel;Research Training;Science;Scientist;South Carolina;Substance Use Disorder;substance use treatment;success;telehealth;Time;Training;Training Programs;Universities;Writing

PROJECT_TITLE: Clinical Scientists Training Program in Addictions at MUSC


ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE  Therapeutic interventions in stroke, the fifth most common cause of death and the leading cause of adult disability in the United States, are currently limited to thrombolytic therapy within a narrow time window and development of effective therapies is urgently required. The object of this application is to test our hypothesis that Malat1 functions as a critical regulator in post-ischemic cerebral angiogenesis, thus affecting long-term neurological outcomes after ischemic stroke. The successful implementation of this proposal will elucidate the essential role of Malat1 in post-stroke angiogenesis and may eventually lead us to identify novel neurorestorative targets for the treatment of ischemic stroke.

PI_NAMEs: SUN, DANDAN  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;Adult;Affect;age effect;Alternative Splicing;angiogenesis;Angiogenesis Inhibitors;Angiogenic Factor;Area;Biological Process;Blood flow;Cause of Death;cell motility;Cell Proliferation;Cells;cerebral artery;cerebral atrophy;Cerebral Ischemia;cerebral microvasculature;Cerebrovascular system;Cerebrum;chromatin remodeling;density;Development;disability;Dosage Compensation (Genetics);effective therapy;Endothelial Cells;Endothelium;Epigenetic Process;Functional disorder;Gene Expression;Gene Modified;Genes;Genetic;Genomic Imprinting;Growth;Hindlimb;Human;human disease;improved;Intervention;Investigation;Ischemia;Ischemic Brain Injury;ischemic injury;Ischemic Stroke;long term recovery;MALAT1 gene;Malignant Neoplasms;Mediating;Middle Cerebral Artery Occlusion;Molecular;Molecular Target;mRNA Expression;Mus;myogenesis;Nervous System Disorder;Neurological outcome;neuronal metabolism;neurorestoration;Non-Small-Cell Lung Carcinoma;novel;Nuclear;Organogenesis;overexpression;Pathogenesis;Pathologic;Physiological Processes;Play;post stroke;post-stroke angiogenesis;Post-Transcriptional RNA Processing;posttranscriptional;protein expression;Proteins;Recovery;Recovery of Function;Regulation;restoration;Rodent;Role;Small RNA;Stroke;stroke model;stroke outcome;synaptogenesis;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Thrombolytic Therapy;Time;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;United States;Untranslated RNA;Vascular blood supply;Vegf inhibition

PROJECT_TITLE: Long Non-Coding RNAs and Cerebral Angiogenesis in Ischemic Stroke

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Diabetes;Heart Disease;Heart Disease - Coronary Heart Disease;Nutrition

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Heart disease is the most common cause of death in industrialized societies. Diabetes is the largest comorbid factor in ischemic heart disease. The significance of the proposed studies is understanding the mechanisms through which heart disease in diabetic patients is accelerated. In the proposed research, we will explore the roles of new metabolic pathways we have discovered in promoting diabetic cardiomyopathy and tissue damage during heart attacks.

PI_NAMEs: GROSS, RICHARD W (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: 12-HETE;Ablation;Acceleration;Acute;Acyl Coenzyme A;acylcarnitine;Acyltransferase;Ankyrin Repeat;Arrhythmia;Binding;Bioinformatics;C-terminal;Calmodulin;calmodulin-dependent protein kinase II;Calpain;Cardiac Myocytes;Catalytic Domain;Cause of Death;comorbidity;Complex;Developed Countries;Development;Diabetes Mellitus;diabetic;diabetic cardiomyopathy;diabetic patient;Dissection;Eicosanoid Modulation;Eicosanoids;Engineering;Esterification;experimental study;Generations;Genetic;Genetic Engineering;Genetic Transcription;Glycerol;Grant;Heart;Heart Diseases;hemodynamics;High Fat Diet;Holoenzymes;Hydrolysis;Hydroxyeicosatetraenoic Acids;IL8 gene;In Vitro;in vivo;Industrialization;Infarction;Inflammation;Inflammation Mediators;Inflammatory;insight;Insulin-Dependent Diabetes Mellitus;interest;Ischemia;Knock-out;Knockout Mice;Ligands;Lipase;Lipids;Lysophospholipase;Lysophospholipids;Macrophage;Mass Spectrum Analysis;Mediating;Metabolic;Metabolic Pathway;metabolic rate;Metabolism;mitochondrial dysfunction;Modeling;Molecular;monocyte;mouse toll-like receptor 4;Mus;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardium;nanomolar;Non-Insulin-Dependent Diabetes Mellitus;Pathologic;Pathway interactions;Pattern;Penetration;Performance;Phospholipase;Phospholipids;Phosphorylation;Physiologic pulse;Plasmalogens;Play;Post-Translational Protein Processing;preference;prevent;Production;Protein Isoforms;Proteolysis;Proteolytic Processing;receptor;Regional Perfusion;Regulation;Research;Resolution;Risk Factors;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Site;Societies;Specificity;stable isotope;Stable Isotope Labeling;Sterility;Structure;Tissues;Transacylase;transacylation;Transgenic Mice;Type 2 diabetic;type I and type II diabetes;Vertebral column;Wild Type Mouse;X-Ray Crystallography

PROJECT_TITLE: Regulation of Myocardial Phospholipases and Lipases in Diabetic Myocardium

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Hematology;Immunotherapy;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Acute myeloid leukemia (AML) is a blood cancer that often generates poor clinical outcomes, whereas antibody- mediated inhibition of MICA/B shedding is a new means of promoting immunity against a variety of cancers and that now has entered into clinical phase. Here we show that the first-of-its-kind inhibitory antibody of MICA/B shedding induces Fc receptor-driven immunity against AML in pre-clinical models, and now we modified it to display higher affinity to Fc activating receptors while maintaining the low affinity to inhibitory receptor. We propose to establish the anti-AML activity of this new molecule, thus generating important information about how to induce protective immunity against AML and supporting clinical transition with the best version of such MICA/B-targeted antibody.

PI_NAMEs: FERRARI DE ANDRADE, LUCAS  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Academia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Affinity;analog;Antibodies;Antigens;antileukemic activity;Binding;Biological Assay;Biology;Blood;Bone Marrow;Bypass;cancer cell;cancer type;CD34 gene;Cell Line;Cells;Cellular Immunity;Cellular Stress;Clinical;Clinical Trials;Collaborations;cytotoxic;Cytotoxic T-Lymphocytes;Dichloromethylene Diphosphonate;Drug Combinations;Effector Cell;Engraftment;Epigenetic Process;experimental group;experimental study;Extracellular Domain;Fc domain;Fc Receptor;Goals;Grant;HDAC4 gene;Hematopoietic Neoplasms;Hematopoietic stem cells;Histone Deacetylase Inhibitor;Human;human model;humanized mouse;IgG1;Immune;Immunity;Immunocompetent;immunogenicity;Immunologic Surveillance;Immunotherapeutic agent;Immunotherapy;in vivo;in vivo Model;inhibiting antibody;leukemia;Leukemic Cell;leukemic stem cell;Lymphocyte;Macrophage;Malignant - descriptor;Malignant Neoplasms;Mediating;Membrane Proteins;Messenger RNA;Metalloproteases;Modeling;Monoclonal Antibodies;monocyte;mouse model;mRNA Expression;Mus;Mutation;Natural Killer Cells;novel;Outcome;Pathway interactions;Patients;Pattern;Phagocytosis;Phagocytosis Induction;Pharmacologic Substance;Phase;Phase I Clinical Trials;Point Mutation;Post-Translational Protein Processing;pre-clinical;Pre-Clinical Model;Protein Disulfide Isomerase;protein expression;Proteins;Publishing;receptor;Regimen;response;Series;Signal Transduction;Solid Neoplasm;Structure;Surface;synergism;T-Lymphocyte;Testing;Time;Translating;Treatment Efficacy;Universities

PROJECT_TITLE: Promoting immunity against acute myeloid leukemia through Fc effector-optimized antibody inhibitory of MICA/B shedding

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-S(09)F]


ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Identification of the lung carcinogenic driver and elucidation of the molecular mechanisms involved in environmental lung carcinogenesis will be of high significance in facilitating our understanding of lung cancer development and will provide valuable information needed for the design of more effective agents for prevention and therapy of lung cancers. This application will test the hypothesis that MEG3 downregulation plays a crucial role in lung carcinogenesis caused by nickel exposure. The overall goal of this proposal is to define the in vivo functions of our novel discovery of MEG3 downregulation and its upstream regulators, downstream effectors, as well as mechanisms, leading to the transformation and tumorigenicity of HBECs following nickel exposure.

PI_NAMEs: COSTA, MAX  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Affect;attenuation;Automobile Driving;Biological;Biological Assay;bronchial epithelium;c-myc Genes;cancer classification;Cancer Patient;carcinogenicity;Carcinogens;Cell Culture Techniques;cell transformation;Cells;Clinical;CRISPR/Cas technology;deep sequencing;design;Development;Down-Regulation;epidemiology study;Epigenetic Process;Epithelial Cells;Event;experimental study;Exposure to;gain of function;Gene Expression Regulation;Genes;Goals;Human;improved;In Vitro;in vivo;Individual;Inhalation;insight;International Agency for Research on Cancer;knock-down;Knockout Mice;Knowledge;Laboratory Study;loss of function;Lung;lung carcinogenesis;Lung Neoplasms;lung tumorigenesis;Malignant - descriptor;Malignant neoplasm of lung;Mediating;Mediator;Modeling;Molecular;mouse model;Mus;new therapeutic target;Nickel;novel;Nude Mice;Oncogenes;Oncogenic;Outcome;overexpression;Oxidative Stress;Play;Pollution;Prevention;professional atmosphere;Prognostic Marker;Reporting;Research;Role;Signal Pathway;Signal Transduction;small hairpin RNA;Structure of parenchyma of lung;System;Testing;therapeutic target;Time;Tissues;Transducers;Tumor Suppressor Genes;Tumorigenicity;Untranslated RNA;Up-Regulation;Xenobiotics

PROJECT_TITLE: MEG3 deletion drives lung tumorigenesis due to environmental nickel exposure

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: PROJECT NARRATIVE This project is aimed to further develop and characterize the mutant Shank3 macaque model of autism spectrum disorder. This model will greatly facilitate the study of neurobiological mechanism of autism and the discovery of translatable biomarkers and therapeutic targets.

PI_NAMEs: DESIMONE, ROBERT  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Academy;Animal Model;Animals;autism spectrum disorder;Behavior;behavior test;Behavioral;Biochemical;Biological Markers;Biomedical Research;Brain;Brain Diseases;California;China;Chinese;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;cognitive function;cohort;Collaborations;Communities;Complex;CRISPR/Cas technology;Data;Development;DNA Sequence Alteration;effective therapy;Electroencephalography;Electrons;Exhibits;Functional disorder;Functional Magnetic Resonance Imaging;Future;Gene Modified;Gene Mutation;Generations;Genes;genetic manipulation;Genome;genome editing;Germ Lines;Glutamates;Heterozygote;Human;Impairment;Lead;Learning;Light;Macaca;Macaca fascicularis;Macaca mulatta;Mediating;Mental disorders;Microscopic;model of autism spectrum disorder;Modeling;Monkeys;motor deficit;mouse genome;mutant;Mutation;neurobiological mechanism;Neurobiology;neuroimaging;neuropathology;neurophysiology;Neurosciences Research;nonhuman primate;Pathologic Processes;Patients;Pattern;Phelan-McDermid syndrome;Physiology;postsynaptic;Prefrontal Cortex;Primates;repetitive behavior;Research;Rest;Rodent;Scaffolding Protein;Science;Scientist;Short-Term Memory;Sleep disturbances;social;social cognition;social reciprocity;sperm cell;Sperm Transport;Structure;Study models;Synapses;Synaptic Potentials;Technology;Testing;therapeutic target;therapeutically effective;zygote

PROJECT_TITLE: Mutant Shank3 macaque monkeys for neurobiological studies of ASD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-W(50)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Kidney Disease

ORG_CITY: Huntington

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MARSHALL UNIVERSITY

ORG_STATE: WV

PHR: Project Narrative The alarming potential for deadly systemic infections, and the high prevalence of multi-drug resistant Serratia marcescens in hospital settings drive the need to identify additional targets for bacterial growth inhibition, which is currently impeded by the lack of reliable animal models. The proposed study will uncover novel details on the spatiotemporal spread of S. marcescens following intraperitoneal infection and will unveil a biological role for the extracellular nuclease produced by this organism during infection. This project will also chart a unified approach for the detailed analysis of other bacterial pathogens with secreted nucleases.

PI_NAMEs: BOGOMOLNAYA, LYDIA M (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Address;Affect;Anatomy;Animal Model;Antibiotics;antimicrobial;Bacteria;Bacterial Drug Resistance;Biological;Biology;Blood Circulation;Catheters;Cell Culture Techniques;Cells;Cessation of life;Clinical;Data;Development;Dialysis patients;Dose;endonuclease;Enzymes;Evaluation;Excision;experimental study;extracellular;Eye;Frequencies;Future;Goals;Gram-Negative Bacteria;Growth;Healthcare;Hemodialysis;High Prevalence;HL-60 Cells;Hospitals;Immune Evasion;Immune response;in vivo;in vivo imaging;Infection;insight;intraperitoneal;Kidney Failure;Knowledge;Mediating;Modeling;Morbidity - disease rate;mouse model;Multi-Drug Resistance;Mus;mutant;neutrophil;Neutrophil Infiltration;novel;nuclease;opportunistic pathogen;Organism;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Patients;Peritoneal Dialysis;Peritonitis;Play;Positioning Attribute;Pre-Clinical Model;Predisposition;priority pathogen;Process;rational design;Research;Resistance;Resolution;respiratory;Role;Serratia;Serratia Infections;Serratia marcescens;Signal Transduction;Site;spatiotemporal;sugar;Surgical wound;SWR/J Mouse;System;Systemic infection;Testing;Time;Tissues;Urinary tract;Virulence Factors;World Health Organization

PROJECT_TITLE: Defining the role of Serratia marcescens nuclease in infection process

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Behavioral and Social Science;Bioengineering;Osteoarthritis;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation

ORG_CITY: ATLANTA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE  Post-traumatic osteoarthritis (PTOA) progression following knee injuries remains problematic in spite of extensive and prolonged post-injury rehabilitation remediation. This proposal aims to determine the responses of knee cartilage to three most commonly modifiable rehabilitation elements that alter the knee joint loading environment following knee injuries using a well-established preclinical rat PTOA model: 1) duration of initial non-weight bearing; 2) level of physical activity; and 3) lower-limb joint kinematics. This innovative work will provide foundational groundwork to better understand the pathogenesis of PTOA and to determine the optimal regenerative rehabilitation principles aimed to mitigate PTOA after traumatic joint injuries.

PI_NAMEs: TSAI, LIANG-CHING  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adult;bone;Cartilage;cartilage degradation;Characteristics;Clinical;Communities;Contracture;contrast enhanced;Cross-Sectional Studies;Data;Development;disability;Disease;Early identification;Education;Elements;Environment;Evaluation;evidence base;Exposure to;Financial Hardship;follow-up;Foundations;Goals;Health;Health Care Costs;Healthcare;Hindlimb;Hindlimb Suspension;Hip region structure;Histopathology;Human;Immobilization;Injury;innovation;insight;Intervention;Investigation;joint injury;joint loading;Joints;kinematics;Knee;Knee Injuries;Knee joint;Knee Osteoarthritis;Knowledge;Left;Limb structure;Literature;Locomotion;longitudinal design;Lower Extremity;Medial meniscus structure;meniscal tear;microCT;Modeling;Modification;Motion;Movement;multidisciplinary;Operative Surgical Procedures;Pathogenesis;Physical activity;Physiological;pre-clinical;Pre-Clinical Model;Predisposition;preservation;prevent;Process;Protocols documentation;Randomized;Rattus;Recommendation;regenerative;regenerative rehabilitation;rehabilitation strategy;Rehabilitation therapy;remediation;Reporting;Research Design;response;Risk;Roentgen Rays;Running;Severities;Skin;Speed;Standardization;Structure;Suspensions;Techniques;Technology;Testing;Time;timeline;tomography;Translational Research;Traumatic Arthropathy;treadmill;Weight-Bearing state;Work

PROJECT_TITLE: Regenerative Rehabilitative Principles in Modulating Weight Bearing and Joint Kinematics to Delay Post-Traumatic Knee Osteoarthritis

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Biotechnology;Cancer

PHR: NARRATIVE Molecular glues display several important pharmacodynamic advantages over drugs that operate through single targets, including enhanced on-target residence time and an ability to fundamentally rewire signal transduction networks. In this proposal, we will seek to build new compounds and next-generation drugs for targeting RAS-MAPK driven cancers that possess molecular glue-like features, thereby offering a new therapeutic path for selectively antagonizing RAS-MAPK driven malignancies in patients. Compounds will be built to overcome key efficacy and safety limitations of currently available drugs, thereby offering a new mode- of-action for targeting the RAS-MAPK pathway.

PI_NAMEs: DAR, ARVIN  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: absorption;Active Sites;Aging;analog;antagonist;Benchmarking;Binding;Binding Sites;Biological Assay;Biology;BRAF gene;Cancer Model;Cell Line;Cells;Chemicals;Clinical;Colorectal Cancer;combinatorial;Complex;Data;design;Development;Diagnosis;Drug Kinetics;Drug Receptors;Drug resistance;Drug Targeting;effective therapy;efficacy evaluation;Excretory function;Extracellular Signal Regulated Kinases;Feedback;Genetic study;Glues;Homologous Gene;Human;Immunotherapy;improved;in silico;In Vitro;in vivo;Individual;inhibitor;insight;interfacial;KRAS2 gene;KSR gene;Laboratories;Ligands;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP Kinase Gene;Mediating;MEKKs;Metabolism;Microsomes;Mitogen-Activated Protein Kinase Inhibitor;Modality;Molecular;Mus;Mutate;Nature;next generation;novel;novel drug class;novel therapeutics;Oncogenes;Oncogenic;Oncology;Organoids;paralogous gene;Parents;Pathway interactions;Patients;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;pharmacophore;Phenotype;Phosphotransferases;Physiological;pre-clinical;Predisposition;Property;Protein Family;Protein Kinase;Proteins;Publishing;Ras/Raf;Rationalization;receptor binding;residence;Resistance;resistance mechanism;response;Roentgen Rays;Role;Safety;scaffold;Series;Signal Transduction;small molecule;Structure;targeted treatment;Testing;Therapeutic;therapeutic development;Therapeutic Index;Time;tool;Toxic effect;treatment duration;triple-negative invasive breast carcinoma;tumor;Work;X-Ray Crystallography;Xenograft procedure

PROJECT_TITLE: Molecular Glues to Target RAS-MAPK Driven Cancers

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Infectious Diseases;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Cytomegalovirus (CMV) infection is a frequent and life-threatening complication that significantly limits the successful outcome of transplantation. The proposal will study the interplay between humoral and cell mediated immunity in preventing viral recrudescence in newly established preclinical models of CMV reactivation after BMT. Thus, we will stringently define the mechanistic basis for cytomegalovirus reactivation following transplantation, enabling the development of readily translatable strategies with high potency that avoid the constraints that apply to current cellular therapies.

PI_NAMEs: HILL, GEOFFREY ROGER (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Address;Allogenic;Anti-viral Agents;Antibodies;Antigen Presentation;Antigens;arm;B-Lymphocytes;Bone Marrow Stem Cell Transplantation;Bone Marrow Transplantation;cell mediated immune response;Cell Survival;Cell Therapy;Cells;Cellular Immunity;Characteristics;Cherry - dietary;Clinical;Clinical Data;clinically relevant;Complement;Complication;Consumption;cytokine;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Vaccines;Data;Development;Disease;Drug resistance;Endothelial Cells;exhaustion;experience;Failure;graft vs host disease;Hematopoietic stem cells;Human;Humoral Immunities;IL-6 inhibitor;Immune;Immune response;Immune system;Immunity;Immunocompromised Host;Immunoglobulin G;Immunoglobulins;Immunology;Immunosuppression;Impairment;improved;improved outcome;in vivo;Inflammation;inhibiting antibody;insight;Interleukin-6;Kidney;Knowledge;Laboratories;Life;Link;Longevity;Mediating;Modeling;Mus;Myelosuppression;Natural Killer Cells;novel;Organ;Outcome;Passive Transfer of Immunity;Pathway interactions;Patient-Focused Outcomes;Persons;pre-clinical;Pre-Clinical Model;preclinical study;Preparation;prevent;Prevention;randomized, clinical trials;Reagent;Recrudescences;Reporter;Reporting;Resistance;response;restraint;Risk;Sampling;Science;seropositive;Seroprevalences;Serotyping;T cell response;T memory cell;T-Cell Development;T-Lymphocyte;Therapeutic Intervention;Time;Tissues;Toxic effect;translatable strategy;Transplant Recipients;Transplantation;Transplantation Immunology;Viral;Viremia;virology;Virus;Virus Replication

PROJECT_TITLE: Defining Protective CMV Immunity after Transplantation

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Transplantation is a cure for many end-stage organ diseases. Highly sensitized patients, those who have developed anti-donor antibody prior to organ transplantation via pregnancy, transfusion, or previous transplantation, remain challenging to transplant compared to their non-sensitized counterparts. As a result, sensitized patients stay longer on the waitlist and experience higher rates of mortality/morbidity. Xenotransplantation has long been proposed as a therapeutic strategy to address the ongoing organ shortage in transplantation and highly sensitized patients have been suggested to be potential first candidates. Xenotransplantation outcomes have improved over the last years due to progress in gene editing of the donor pig as well as improved immunosuppression. Despite this, antibody-mediated rejection (AMR) remains common and prevents long-term graft survival and clinical translation. Therefore, this project seeks to use a preclinical nonhuman primate model to test new therapeutic strategies targeting post-xenotransplantation humoral response, with the ultimate goals of minimizing graft rejection, preserving protective immunity, and maximizing patient health. The results of the study would directly inform the strategy for the first human xenotransplants and lower the risk of humans undergoing xenotransplantation. We anticipate future advances to move into clinical trials to help further prolong kidney transplant function and patient survival, thus extending the lifespan and quality of life of patients with kidney failure.

PI_NAMEs: KWUN, JEAN  (contact)

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: Acceleration;Address;Adjuvant Therapy;Affect;allograft rejection;allotransplant;anergy;Antibody Formation;Antibody Response;Antibody titer measurement;antibody-mediated rejection;Antigens;B cell repertoire;B-Lymphocytes;Clinic;Clinical;clinical translation;Clinical Trials;Complement;conditioning;Data;Death Rate;desensitization;Development;Disease;donor-specific antibody;efficacy evaluation;Elements;End stage renal failure;Engineering;experience;Exposure to;extend lifespan;Family suidae;first-in-human;Fostering;Future;Genes;Genetic;Genetic Engineering;Goals;graft failure;Graft Rejection;Graft Survival;Health;Human;Immune;Immune response;Immunity;Immunologics;Immunosuppression;Impairment;improved;Industry Collaboration;Infection;Intervention;Kidney;Kidney Failure;Kidney Transplantation;Letters;Lymphocyte;Macaca mulatta;Mediating;Modeling;Modification;Morbidity - disease rate;nonhuman primate;novel;novel therapeutic intervention;Organ;Organ Transplantation;Outcome;Patients;Phenotype;Plasma Cells;Population;Positioning Attribute;post-transplant;pre-clinical;Pregnancy;preservation;prevent;Primates;Proteasome Inhibitor;Quality of life;Regimen;response;Risk;Skin;System;T-Lymphocyte;targeted agent;targeted treatment;Testing;Therapeutic;Transfusion;Translations;transplant model;Transplantation;United States;United States National Institutes of Health;vaccine response;Viral;Wait Time;Waiting Lists;Xenograft procedure

PROJECT_TITLE: Overcoming humoral rejection after xenotransplantation in sensitized nonhuman primate recipients


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE The retina is a small, disc-shaped piece of tissue located in the back of the eye that is responsible for vision. During development of the retina, over 100 diffent types of cells are produced that work together to allow for proper vision. This project aims to study how the production of this enormous cell diversity is regulated during development to ensure that the correct number of each of these cell types are produced and that they are produced evenly across the surface of the retina.

PI_NAMEs: DELGADO, RYAN  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Back;Bar Codes;base;Benchmarking;Birth;Brain;career;Cell division;Cell Survival;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Competence;Complex;CRISPR/Cas technology;Cues;Data;Data Set;daughter cell;design;Development;Distant;DNA;DNA Sequence;Environment;Evolution;experience;Eye;Foundations;Gene Expression Profile;Generations;Genes;Genetic Transcription;Genomics;Goals;Guide RNA;Heritability;in vivo;Individual;Inherited;Interneurons;invention;Investigation;Knockout Mice;Laboratories;Light;medical schools;Mentors;Modeling;Molecular;Morphology;Neurons;novel;Output;Pattern;Phase;Physiological;postnatal;prime editor;Process;Production;progenitor;programs;Publishing;response;Retina;Retinal Cone;Retinal Ganglion Cells;retinal neuron;retinal progenitor cell;Role;Series;Shapes;single cell ATAC-seq;single-cell RNA sequencing;Sister;Site;small molecule inhibitor;Solid;spatiotemporal;Specific qualifier value;Supervision;Surface;Testing;Time;Tissues;tool;tool development;Tracer;Training;training opportunity;Transgenic Organisms;Trees;Vertebrate Photoreceptors;Vision;Work

PROJECT_TITLE: The role of lineage in the temporospatial genesis of retinal bipolar cell subtypes


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: Project Narrative As the world’s population continues to age, the prevalence of Alzheimer’s disease will increase, generating greater urgency for creating methods capable of identifying individuals at risk for decline. This project will facilitate development of tools for enhancing early detection of Alzheimer’s disease, which in turn will allow for earlier intervention and improved methods to screen patients for clinical trials. Results will provide clinically applicable information on how olfactory deficit patterns manifest across early stages of the disease, and can potentially be used for improving diagnostic accuracy compared to normal aging, which in turn can reduce time spent in workups and can reduce delays in initiating treatment.

PI_NAMEs: MOTTER, JEFFREY NICHOLAS (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Address;Affect;Age;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer’s disease biomarker;amnestic mild cognitive impairment;Apolipoprotein E;Apolipoproteins;Area;Award;Binding;Biological Markers;Biometry;Brain;Brain region;Classification;Clinical;clinical application;Clinical Trials;Cognitive;Dementia;Detection;Development;diagnostic accuracy;Disease;Disease Progression;Early Diagnosis;Early Intervention;Education;entorhinal cortex;Environment;Etiology;Evaluation;experience;experimental study;Fostering;functional decline;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;Funding;Genotype;Goals;Hippocampus;Image;Impaired cognition;Impairment;improved;Individual;Invaded;Knowledge;Measures;Mechanics;medial temporal lobe;Memory;Memory impairment;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;Methods;mild cognitive impairment;Monitor;mortality;neural;neural circuit;Neurobiology;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimaging;neuromechanism;neuropathology;Neuropsychology;normal aging;Odors;older adult;olfactory bulb;Olfactory Cortex;Olfactory dysfunction;Olfactory Pathways;Participant;Pathology;patient screening;Patients;Pattern;peer coaching;piriform cortex;Plasma;Population;Positioning Attribute;Prevalence;Procedures;Process;programs;Psychometrics;Reporting;Research;Research Personnel;Research Project Grants;Research Proposals;Resources;response;responsible research conduct;Retrieval;Risk;ROC Curve;Role;Scanning;Semantics;Signal Transduction;skill acquisition;skills;Smell Perception;Stimulus;Structure;Supervision;System;tau Proteins;Techniques;Testing;Time;tool;tool development;Training;Translating;United States National Institutes of Health;Variant;verbal

PROJECT_TITLE: Odor memory and functional neuroimaging in cognitively impaired older adults and Alzheimer's disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: BIOPHYSICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Narrative The binding of glutamate to metabotropic glutamate receptors (mGluRs) and of g-aminobutyric acid (GABA) to GABAB receptors drives signaling cascades that start with G protein binding to the intracellular side of the receptor. We propose to obtain the cryo-electron microscopy (cryo-EM) structures of mGluR2, mGluR5 and GABAB receptor in complex with their G protein partners and interrogate the signaling mechanism with in vitro assays and molecular dynamics (MD) simulations. As defects in glutamatergic and GABAergic signaling are linked to many neurological conditions such as Parkinson's disease, schizophrenia, drug addiction, depression, and pain, this knowledge will be ultimately used for the design of novel therapeutic strategies to combat these disorders.

PI_NAMEs: SKINIOTIS, GEORGIOS  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Address;Agonist;Aminobutyric Acids;Binding;Binding Proteins;Binding Sites;Biochemical;Biological Assay;Cell membrane;Central Nervous System;Central Nervous System Diseases;combat;Communication;Complement;Complex;computer studies;conformational conversion;Coupled;Couples;Coupling;Cryoelectron Microscopy;Cysteine-Rich Domain;Defect;design;Detergents;dimer;Disease;Drug Addiction;drug discovery;Environment;extracellular;Extracellular Domain;Family;fly;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;Glutamate Receptor;Glutamates;GRM5 gene;GTP-Binding Proteins;Heterotrimeric GTP-Binding Proteins;in vitro Assay;insight;Knowledge;Length;Ligand Binding;Link;Lipids;Maps;Membrane;Mental Depression;metabotropic glutamate receptor 2;metabotropic glutamate receptor type 1;Metabotropic Glutamate Receptors;Micelles;Molecular;Molecular Conformation;molecular dynamics;Mutagenesis;Mutation;nanodisk;Nerve Degeneration;Neurologic;neuronal excitability;neuropsychiatry;neurotransmission;novel therapeutic intervention;Pain;Parkinson Disease;pharmacologic;Phospholipids;Physiological;Preparation;Property;protein activation;protein complex;Proteins;Protomer;receptor;Receptor Activation;receptor coupling;receptor function;release of sequestered calcium ion into cytoplasm;Repression;Resolution;Role;Schizophrenia;Side;Signal Transduction;Site;Specificity;structural determinants;Structure;Synaptic plasticity;Synaptic Transmission;System;Testing;therapeutic target;Transmembrane Domain;Venus;Work

PROJECT_TITLE: Structural Basis of Signal Instigation Through Family C GPCRs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-C(02)M]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_CITY: WACO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BAYLOR UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative The exponential growth in the nonmedical use of prescription opioids, including the commonly-prescribed oxycodone, has contributed strongly to devastating national public health consequences including addiction, overdose and transition to use of illicit opioids such as heroin. This proposal combines a novel rodent model of oxycodone abuse with cutting-edge chemogenetic technology for dissection of the neural circuits and mechanisms which underlie the development of opioid dependence and to help identify potential therapeutic approaches and targets for medications development.

PI_NAMEs: NGUYEN, JACQUES DUCHUY (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: acute stress;addiction;Adenosine;Amygdaloid structure;Animals;Anxiety;Attenuated;Behavior;Behavioral;behavioral pharmacology;behavioral response;Biochemical;Brain;career development;Cell Nucleus;Chronic;Complement;Coupled;Dependence;design;designer receptors exclusively activated by designer drugs;Development;Dissection;Drug abuse;Drug Addiction;Drug Exposure;Drug Prescriptions;drug seeking behavior;Drug usage;drug withdrawal;Dynorphin A;Dynorphins;emotional behavior;Ensure;experience;experimental study;Gene Silencing;Genetic;Genetic Suppression;genetic technology;Growth;Health;Heroin;Hour;Hypothalamic structure;illicit opioid;Immunohistochemistry;innovation;insight;Institution;Intravenous;Investigation;kappa opioid receptors;knock-down;Laboratories;Ligands;Mediating;Mediation;Mentors;Methods;Microinjections;Modality;Modeling;Molecular;Molecular Analysis;multidisciplinary;negative affect;neural;neural circuit;Neural Pathways;neuroadaptation;neurobiological mechanism;neuromechanism;Neurons;neurotransmission;Nociception;novel;Opiate Addiction;Opioid;opioid abuse;opioid use;Output;Overdose;Oxycodone;oxycodone self-administration;paraventricular nucleus;Pathway interactions;Percocet;Pharmaceutical Preparations;Pharmacology;Phase;Phenotype;Physiological;preclinical study;prescription opioid;prescription opioid addiction;prescription opioid misuse;Process;prodynorphin;Psychological reinforcement;Public Health;Rattus;Receptor Signaling;regional difference;Relapse;Reproducibility;Research Institute;Research Training;Rewards;Rodent Model;Self Administration;Signal Induction;Signal Transduction;skills;stimulus processing;Stress;System;Techniques;Testing;Therapeutic;Time;tool;Training;transmission process;United States National Center for Health Statistics;Viral;Viral Vector;Withdrawal;Work

PROJECT_TITLE: Elucidating behavior and neural circuits underlying opioid addiction and dependence


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Cardiovascular disease is the leading cause of morbidity and mortality, especially among individuals with low socioeconomic status, and addressing the lack of access to cardiac rehabilitation among individuals with low socioeconomic status may be an effective strategy for reducing cardiovascular disease disparities among these high risk medically underserved populations. We propose a theory-based intervention, delivered by community health workers, to increase cardiac rehabilitation participation among individuals with low socioeconomic status that addresses the multi-level barriers they face to enrollment. These research efforts will result in a cardiac rehabilitation intervention that will boost enrollment in patients with low socioeconomic status and reduce the cardiovascular disease disparities.

PI_NAMEs: MATHEWS, LENA MOLLY (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: acceptability and feasibility;Accounting;Address;Age;arm;Award;Behavior;behavior change;Behavior Therapy;Behavioral;Biometry;Cardiac rehabilitation;Cardiology;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;career;career development;Characteristics;Clinical;Clinical Investigator;Clinical Research;Communities;community advisory board;community based participatory research;community engagement;Community Health Aides;comorbidity;Complex;Counseling;Data;Death Rate;Development Plans;disease disparity;Disparity;Education;efficacy testing;Electronic Health Record;Eligibility Determination;Enrollment;Ensure;Environment;Epidemiology;ethnic minority;ethnic minority population;Evaluation;Event;evidence base;exercise training;experience;Face;Feasibility Studies;feasibility testing;Feedback;Fellowship;Foundations;Future;Gender;Goals;Health;health disparity;Health system;Healthcare Systems;Heart;high risk;Hospitalization;Human Resources;implementation science;improved;Individual;Intervention;Intervention Trial;Interview;Knowledge;Learning;Life Style;Link;low socioeconomic status;marginalized population;Medical;medically underserved population;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;Motivation;multi-component intervention;Names;navigator intervention;Obesity;Outcome;Participant;patient engagement;patient navigator;patient oriented research;Patients;Persons;Phase Ia Trial;Phase Ib Trial;Population;Prevention strategy;Prevention therapy;Process;professor;programs;Provider;public health priorities;Qualitative Methods;Race;racial minority;racial minority population;Randomized, Controlled Trials;recruit;Recurrence;Research;Research Methodology;Research Personnel;satisfaction;Scientist;Secondary Prevention;skill acquisition;skills;Social support;sociodemographics;Socioeconomic Status;Structure;System;Testing;theories;Theory of Change;therapy design;therapy development;Training;Underserved Population;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: Addressing Low Cardiac Rehabilitation Participation among Patients with Low Socioeconomic Status

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Pediatric;Prescription Drug Misuse;Prevention;Substance Misuse

ORG_CITY: Newark

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE. Benzodiazepines are frequently prescribed to adolescents and young adults, yet we lack key data on misuse, abuse, and overdose risk following benzodiazepine treatment and on what policies reduce benzodiazepine- related harms in young people. The proposed research will examine the risk of overdose and harmful substance use following benzodiazepine treatment and will evaluate whether state prescription drug monitoring program features are associated with a reduction in benzodiazepine-related harms and risky benzodiazepine prescribing. As more young people seek treatment for mental illness, it is of urgent public health importance to investigate the misuse and abuse potential of commonly prescribed pharmaceutical treatments and to consider modifiable factors, such as existing prescription drug monitoring programs, that can be leveraged to reduce harms.

PI_NAMEs: BUSHNELL, GRETA  (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: abuse liability;Address;Adolescent;Adolescent and Young Adult;Adolescent Development;Adult;Age;age group;Alternative Medicine;alternative treatment;Anxiety;Area;Award;benzodiazepine abuse;benzodiazepine misuse;Benzodiazepines;career;Cessation of life;Community Practice;Coping Skills;Data;Data Set;Databases;Dependence;Detection;Development;Disease;Dose;Drug abuse;Drug Prescriptions;Early Intervention;Electronics;Emergency department visit;emerging adult;Evaluation;experience;Future;Harm Reduction;Health Resources;Heterogeneity;improved;Individual;innovation;Intervention;Knowledge;Life;Measures;Medicaid;Medical;Medicine;Mental Depression;Mental disorders;Mentored Research Scientist Development Award;Methodology;Methods;misuse of prescription only drugs;Monitor;Morbidity - disease rate;Opioid;opioid epidemic;opioid use;Outcome;Overdose;overdose death;overdose risk;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Policies;prescription monitoring program;prescription opioid;prevent;Privatization;programs;Provider;Public Health;Reporting;Research;Research Design;Research Personnel;Risk;Risk Factors;risk stratification;Running;Safety;Sampling;sedative;Sleep Disorders;Substance abuse problem;substance misuse;substance use;Surveys;System;Time;Training;Training Programs;Tranquilizing Agents;treatment risk;twelfth grade;young adult;Youth

PROJECT_TITLE: Benzodiazepine-related harms in young people: Informing policy, interventions, and prescribing

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Orphan Drug;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Influenza virus infection causes severe lung damage and is associated with hundreds of thousands of respiratory deaths per year worldwide. A specialized subset of T cells known as regulatory T cells promotes resolution of lung inflammation and repair of lung damage following influenza infection. By studying how epigenetic mechanisms control regulatory T cells and how regulatory T cell-generated molecules induce lung repair, we will ascertain fundamental mechanisms of recovery from influenza, which will lead to novel therapies that decrease the morbidity and mortality caused by influenza.

PI_NAMEs: SINGER, BENJAMIN DAVID (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Adaptor Signaling Protein;Alveolar;alveolar epithelium;Amphiregulin;Anti-viral Agents;Anti-viral Therapy;AREG gene;Back;Bronchoalveolar Lavage;Caring;Case/Control Studies;cell type;Cells;Cessation of life;Clinical Research;computational platform;Control Locus;Critical Illness;Cytosine;Data;Death Rate;Development;dimensional analysis;DNA;DNA Binding;DNA Maintenance;DNA Methylation;DNA Modification Methylases;Epigenetic Process;epithelial repair;Epithelium;experimental study;Flow Cytometry;FOXP3 gene;Gene Expression Profile;gene repair;gene repression;Generations;Genes;Genetic Transcription;genomic locus;Growth Factor;Guanine;high dimensionality;Human;Infection;Inflammation;Influenza;Influenza A virus;influenza infection;innovation;Intensive Care Units;Link;Lung;lung injury;lung repair;Mediating;methylation pattern;Morbidity - disease rate;mortality;mouse model;Mus;novel;novel therapeutics;Pathway interactions;Patient Selection;Patients;Pharmaceutical Preparations;Phase;Physiological;Play;Pneumonia;programs;Protein Isoforms;Proteins;Publishing;Pulmonary Inflammation;Reagent;Recovery;Recovery of Function;recruit;Regulatory Element;Regulatory T-Lymphocyte;repair function;repaired;Research Infrastructure;Resolution;respiratory;Risk;Role;seasonal influenza;Sorting;Supportive care;System;T-Lymphocyte Subsets;Technical Expertise;Testing;Therapeutic;Time;Tissues;Translating;Viral;Viral Pneumonia;Virus Diseases;Work

PROJECT_TITLE: Mechanisms of regulatory T cell-mediated recovery from severe influenza A virus infection

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Neural systems integrate response features (behavioral, HPA, and autonomic) to enable coping with stress. This proposal will utilize animal studies to elucidate novel neural pathways and mechanisms capable of linking active behavior with attenuated HPA and sympathetic responses, and passive behavior with exaggerated HPA and sympathetic responses following chronic stress exposure. Given the association between passive coping and disease susceptibility, these studies will help to link activity patterns in novel pathways involved in reversing behavioral, HPA, and autonomic features of passive coping responses, and in so doing will aid in the development of future interventions for the treatment of stress-related diseases.

PI_NAMEs: LALUMIERE, RYAN T;RADLEY, JASON J (contact)

PROJECT_TERMS: Acute;acute stress;Animals;Attenuated;Aversive Stimulus;base;Behavior;Behavioral;Chronic;Chronic stress;coping;Coping Behavior;Data;Development;Disease;Disease susceptibility;Endocrine;Exposure to;Freezing;Functional disorder;Future;Glucocorticoids;Hormones;Human;Immobilization;Intervention;Link;Maintenance;Mammals;Maps;Measures;Medial;Mediating;Mediator;Mental disorders;midbrain central gray substance;Nature;neural;neural circuit;Neural Pathways;Neurobiology;neuromechanism;Neurons;neuroregulation;Neurosecretory Systems;novel;optogenetics;Output;Pathogenesis;Pathway interactions;Pattern;Physiological;Positioning Attribute;Predisposition;Prefrontal Cortex;pressure;prevent;Rattus;Recording of previous events;resilience;response;restraint;Rodent;Role;Shock;Stress;Stress and Coping;stress resilience;stressor;Synapses;System;Systemic disease;Testing;Translations;Viral

PROJECT_TITLE: Neural circuits and mechanisms underlying active and passive stress coping

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Chagas disease is a major vector borne parasitic disease caused by the protozoan parasite Trypanosoma cruzi, and a major gap is that patients at increased risk of developing severe disease cannot be distinguished from those who may remain in the asymptomatic chronic stage, making any prognosis uncertain and complicating patient care and treatment. Our general objective is to determine the effects of T. cruzi parasite diversity on disease progression during the chronic phase by following naturally-infected Chagasic macaques and associating parasite genetic diversity with the immune response and clinical disease progression over time. These studies will allow testing for the role of parasite genetic diversity in shaping disease progression and are expected to lead to improved patient care and control of this important disease.

PI_NAMEs: DUMONTEIL, ERIC  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Americas;Animal Model;Animals;Biodiversity;Biological Markers;Blood;Blood specimen;burden of illness;candidate marker;Cessation of life;Chagas Disease;chagasic cardiomyopathy;Chronic;chronic infection;Chronic Phase;Clinical;cohort;Data;disability-adjusted life years;Disease;Disease Progression;early detection biomarkers;Early identification;Economics;Electrocardiogram;Fibronectins;follow-up;Gene Expression Profile;Genetic Variation;Genotype;heart function;Human;Immune;Immune response;Immunology;improved;In Vitro;in vivo;Infection;Lead;Life;Macaca;Macaca mulatta;Measures;Megacolon;Methods;Monitor;Names;neglected tropical diseases;Parasites;Parasitic Diseases;Pathogenesis;Patient Care;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Plasma;Play;potential biomarker;Predisposition;Prognosis;response;Risk;Role;Shapes;single-cell RNA sequencing;System;Testing;Time;transcriptomics;translational impact;Trypanosoma cruzi;Validation;vector;vector-borne;Virulence;Work;years of life lost

PROJECT_TITLE: Intra-host Trypanosoma cruzi parasite dynamics in naturally-infected macaques and Chagas disease progression

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: TEMPE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Although the hand’s sensorimotor control mechanisms have been extensively studied, our limited understanding of these mechanisms still challenges our ability to improve or restore sensorimotor function following traumatic or neurological injuries. We propose a novel approach – combining a dexterous manipulation task, robotic grasp analysis and surface electromyography – to quantify mechanisms responsible for coordination of grasp and manipulation forces. If the proposed exploratory studies are successful, our findings will enable clinicians to extract information about the state of the hand’s sensorimotor function that can potentially contribute to guide clinical decisions and the design of assistive and/or rehabilitation devices.

PI_NAMEs: SANTELLO, MARCO  (contact);WU, YEN-HSUN

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Basic Science;Carpal Tunnel Syndrome;Clinical;clinical application;Clinical Assessment Tool;clinical translation;cost;Coupled;Data;design;Devices;dexterity;Digit structure;Electromyography;Exertion;experience;Feedback;Focal Dystonias;Foundations;Funding;Goals;grasp;Hand;hand rehabilitation;high reward;high risk;Human;Impairment;improved;Injury;insight;Intervention;Joints;Knowledge;Laboratories;Lifting;Mathematics;median nerve;Memory;Muscle;neglect;Nerve compression syndrome;Nervous System Disorder;Nervous System Trauma;neuromuscular system;novel;novel strategies;Patients;Performance;Peripheral Nervous System Diseases;Positioning Attribute;preservation;prevent;Prevention;Property;Recovery of Function;Rehabilitation device;Research;Resistance;Robotics;Role;Self-Help Devices;sensorimotor control mechanism;Sensorimotor functions;sensory feedback;sensory integration;Spinal cord injury;Stimulus;Surface;Tactile;Testing;Time;tool;Torque;Translating;Translations;Traumatic injury;United States National Institutes of Health;Work

PROJECT_TITLE: Coordination of human grasp and manipulation forces

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Hematology;Infectious Diseases

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Narrative We hypothesize that extramedullary megakaryocytes have immune specialized functions that are dictated by their tissue environment. Therefore, megakaryocytes, and the platelets they produce, are responsive to tissue injury or infection in ways that may impact disease outcomes.

PI_NAMEs: MORRELL, CRAIG N (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Acceleration;Acute-Phase Reaction;Affect;Antigen Presentation;Antigens;Bacterial Pneumonia;Biological Models;Blood Platelets;Bone Marrow;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cells;clinical investigation;Communicable Diseases;Coronavirus;Data;Development;Disease;Disease Outcome;Environment;Extramedullary;Goals;Helper-Inducer T-Lymphocyte;hematopoietic differentiation;Hematopoietic stem cells;Homeostasis;Immune;Immune response;Immune system;In Vitro;in vivo;Infection;Inflammatory;Influenza;Interdisciplinary Study;Journals;Lung;Maintenance;Mediating;Mediator;Megakaryocytes;monocyte;Morbidity - disease rate;mortality;mouse model;novel;pathogen;Pathogenicity;Phase;Phenotype;Platelet Count measurement;platelet function;Process;Production;progenitor;Publishing;Research;Research Personnel;response;Response to stimulus physiology;Role;Shapes;Source;Spleen;Stimulus;T-Lymphocyte;Thrombosis;tissue injury;Tissues;trafficking;uptake;Virus Diseases;Work;working group

PROJECT_TITLE: Tissue Dependent Megakaryocyte Functions

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE While there are clear theoretical and well-documented empirical associations between more money and living longer, the size of the causal link is not clear because of practical and ethical challenges to giving money to people in a truly random fashion. This project studies the long-term consequences for mortality and life expectancy of a major land redistribution program in New Zealand that randomized the award of resources, allowing causal estimates of the link between wealth and health. The results of this research will inform health policy debates on wealth-transfer programs to improve later life outcomes across generations.

PI_NAMEs: ROBERTS, EVAN W (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Address;Adult;Affect;Age;Aging;aging process;Award;Binding;Birth;Birth Order;Cause of Death;Cessation of life;Child;Child Health;Child Mortality;Childhood;cohort;Communicable Diseases;comparative;Data;Data Set;Death Records;design;Economics;Employment;Ensure;Ethics;Etiology;experimental study;Family;Farm;farmer;follow-up;Gender;gender difference;Generations;Health;health disparity;Health Insurance;Health Policy;Health Status;Housing;improved;Income;Inequality;infancy;interest;intergenerational;International;Knowledge;late life;Life;Life Cycle Stages;Life Expectancy;life span;Link;Longitudinal Studies;Measures;Mediation;men;middle age;Modernization;mortality;New Zealand;novel;Occupational Status;offspring;Outcome;Parents;Participant;Pathway interactions;Pattern;payment;Persons;Pilot Projects;Policies;Population Process;Privatization;programs;Property;prospective;Public Policy;Randomized;Records;Research;Research Design;Research Personnel;residence;Resources;Risk Factors;Role;rural residence;Sampling;Savings;sex;Siblings;social;Social Policies;Social Processes;Social status;Societies;Socioeconomic Status;Spouses;Subgroup;System;Testing;Time;urban residence;Woman

PROJECT_TITLE: Casual effects of wealth on health: Evidence from lifetime follow-up of randomized land redistribution

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: BURLINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Project Narrative: APOBEC family cytidine deaminases are the cause of the second-most abundant type of mutation during cancer development. We recently identified APOBEC3A and APOBEC3B as, respectively, the primary and secondary sources of cytidine deaminase activity in breast cancer. This proposal investigates these enzymes' surprising ability to induce insertion/deletion mutations as well as how APOBEC3A-induced mutation is regulated through transcriptional activation, proteasomal degradation, and DNA repair mechanisms.

PI_NAMEs: ROBERTS, STEVEN A (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Affect;base;Base Excision Repairs;Base Sequence;Bioinformatics;brca gene;BRCA1 gene;BRCA2 gene;Breast Cancer Cell;Breast Cancer cell line;Bypass;Cancer Etiology;Cell Culture Techniques;Cell Physiology;Cells;clinical application;Cytidine Deaminase;Defect;Deletion Mutation;Deoxyuridine;Development;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Pathway;DNA replication fork;Double Strand Break Repair;Drug resistance;Enzymes;Etiology;Evolution;Excision;Family;Family member;Frequencies;Genetic Heterogeneity;Genetic Recombination;Genetic Transcription;Genomics;homologous recombination;Human;Human Cell Line;Induced Mutation;Insertion Mutation;insertion/deletion mutation;insight;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;member;mRNA Expression;multicatalytic endopeptidase complex;Mutagenesis;Mutate;Mutation;neoplastic cell;Oncogenes;Pathway interactions;Patient-Focused Outcomes;Patients;posttranscriptional;Proteins;Regulation;Relapse;repaired;Role;Signal Pathway;Site;Source;System;targeted treatment;Therapeutic;therapeutic development;therapeutic target;Trans-Activators;transcription factor;Transcriptional Activation;tumor;tumor progression;Tumor Suppressor Genes;tumorigenesis;Ubiquitin;Up-Regulation;Virus;Yeasts

PROJECT_TITLE: Regulation of APOBEC3 cytidine deaminase-induced mutation during cancerdevelopment

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Chlamydia trachomatis, an agent of sexually transmitted disease, relies on a specialized secretion mechanism to deploy proteins exerting anti-host activities essential to pathogenesis. This proposal contains work designed to determine their specific contributions to chlamydial disease.

PI_NAMEs: FIELDS, KENNETH A (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Actins;Acute Disease;Address;Affect;Animal Model;Animals;Binding;Biochemical;Biological;Biology;Cell membrane;Cell Physiology;Cells;Cellular biology;Chlamydia;Chlamydia Infections;Chlamydia muridarum;Chlamydia trachomatis;Chronic Disease;Communities;comparative;Cytoskeleton;Data;design;Detection;Development;Disease;Disease Progression;economic impact;Epithelial Cells;Event;Genetic;Grant;Growth;Health;health economics;Host Defense;Human;human pathogen;Immune;immunopathology;In Vitro;in vivo;Infection;Invaded;Link;Lipids;Mediating;member;Membrane;Microbiology;Modeling;Modification;Molecular;Mus;mutant;Mutation;novel;obligate intracellular parasite;Organelles;Outcome;parasitism;pathogen;Pathogenesis;Pathology;Pathway interactions;polymerization;Polymers;Prevalence;Process;Proteins;reproductive tract;Resources;Role;Science;Sexually Transmitted Agents;Sexually Transmitted Diseases;socioeconomics;Source;Testing;Time;trafficking;Type III Secretion System Pathway;Vacuole;vesicle transport;Virulence;Work

PROJECT_TITLE: Chlamydia type III effectors affecting the host actin-based cytoskeleton

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pain Research;Palliative Care;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Persistent pain is severely under-detected and under-managed in older persons with Alzheimer’s Disease and related dementias (ADRD). Training family caregivers of persons with ADRD in observational pain assessment and subsequent communication of the assessment results to a health care provider has the potential to help address under-detection and under-management of pain in this population. This research will test the efficacy of the Pain Identification and Communication Toolkit (PICT), a multicomponent intervention for ADRD caregivers that provides training in observational pain assessment and coaching in effective pain communication techniques.

PI_NAMEs: RIFFIN, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Alzheimer's disease related dementia;Analgesics;Area;Articulation;attentional control;Basic Science;Behavior assessment;behavior change;Behavioral;Behavioral Symptoms;Belief;Black race;care delivery;care recipients;caregiver education;Caregivers;caregiving;Caring;Clinical;Clinical Trials;Communication;Communication impairment;Communities;Confusion;Dementia caregivers;dementia caregiving;Detection;Development;Distress;effective intervention;efficacy evaluation;efficacy testing;Elderly;ethnic diversity;ethnic minority population;Ethnic Origin;evidence base;experience;Face;Family;Family Caregiver;family support;Frustration;Funding;Future;health literacy;Health Personnel;Hispanic;Impaired cognition;improved;Individual;Infrastructure;innovation;Institutionalization;Intervention;intervention refinement;Knowledge;Long-Term Care;Manuals;Measurable;Medicine;Mental Depression;Minority Groups;Modeling;multi-component intervention;multi-racial;Nerve Degeneration;New York;Nonpharmacologic Therapy;novel;older adult;Older Population;Outcome Study;Pain;Pain Assessment Tool;Pain management;Pain Measurement;pain model;pain symptom;Patient Self-Report;Patients;Persistent pain;Persons;pharmacologic;Physical Function;pilot test;pilot trial;Play;Population;Practice Guidelines;pragmatic trial;precision medicine;primary outcome;programs;psychological symptom;Quality of life;Race;racial diversity;racial minority population;Randomized;Recommendation;Regimen;Research;Research Personnel;Role;routine care;routine practice;Science;secondary outcome;Self Efficacy;Services;Severities;Site;skills;Social isolation;Social Workers;socioeconomics;Techniques;theories;therapy development;Training;Training Programs;United States National Institutes of Health;verbal;virtual;Work

PROJECT_TITLE: The Pain Identification and Communication Toolkit: A Training Program to Support Family Caregivers of Persons with ADRD


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: AUGUSTA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Despite making up ~40% of acute kidney injury (AKI) cases, women are considered protected from AKI and are underrepresented in AKI research studies. Pregnancy is a unique physiological condition that places high demands on the kidneys, and recent clinical studies have identified AKI as a risk factor for poor fetal and maternal outcomes. Results from our proposed studies will establish a role for subclinical renal injury after AKI to impair the necessary renal, hemodynamic, and immune adaptations required for a health pregnancy, and potentially provide mechanistic insight to guide better clinical care for all AKI patients.

PI_NAMEs: SULLIVAN, JENNIFER C (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: absorption;Acute Renal Failure with Renal Papillary Necrosis;Address;adverse outcome;adverse pregnancy outcome;Biological Availability;Blood Plasma Volume;Blood Vessels;Body System;Cardiovascular system;Caring;Chronic Kidney Failure;Clinical;clinical care;Clinical Data;Clinical Research;Clinical Trials;Conceptions;Coupled;Creatinine;Data;Event;Exhibits;experience;Experimental Models;Failure;Female;fetal;Fetal Development;Fetal Growth;Fetal Growth Retardation;Fetus;Foundations;Glomerular Filtration Rate;Goals;Guidelines;Health;healthy pregnancy;hemodynamics;Hospitalization;Human;Immune;Impairment;improved;Injury;Injury to Kidney;insight;Ischemia;Kidney;kidney dysfunction;Knowledge;Lead;Low Birth Weight Infant;male;Maternal Health;maternal outcome;Measurement;Mediating;Mediator;Modeling;mortality;Mothers;new therapeutic target;Nitrates;Nitric Oxide;Nitric Oxide Synthase;Nitrites;novel;Outcome;Patients;Perfusion;Perinatal;Perinatal Care;Peripheral Resistance;Physiological;Physiological Adaptation;Plasma;post pregnancy;pre-clinical;Pregnancy;Pregnancy Outcome;prenatal;prevent;Prevention;Production;Publishing;Rattus;Recording of previous events;Recovery;Regulatory T-Lymphocyte;Reperfusion Therapy;Reporting;Research;research study;Risk;Risk Factors;Role;screening;Serum;sex;Sodium;Sprague-Dawley Rats;System;Testing;United States;urinary;Vascular Diseases;Woman;women's outcomes

PROJECT_TITLE: Mechanisms of subclinical renal injury in females following AKI: implications  for adverse pregnancy outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Sepsis is a deadly condition caused by a dysregulated immune response to infection which affects 700,000 patients per year in the US alone. Early and accurate diagnosis of sepsis, and infection underlying sepsis is critical to inform treatment choices and to prevent serious organ injury and death, but diagnostic options remain limited. This proposal addresses this unmet medical need with the development of a minimally invasive blood test based on a multi-omics profiling of circulating cell-free DNA to simultaneously inform host responses, quantify organ injury and identify infection underlying sepsis.

PI_NAMEs: DE VLAMINCK, IWIJN  (contact);SCHENCK, EDWARD JAMES

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: accurate diagnosis;Acute Renal Failure with Renal Papillary Necrosis;Address;Affect;biobank;Bioinformatics;Biological Assay;bisulfite;Blood;Blood Tests;Cell Death;cell free DNA;cell type;Cells;Cessation of life;Chemistry;Classification;Clinical;Coffee;cohort;Complication;COVID-19;Critical Illness;Cytosine;Data;Data Set;Deamination;Development;Diagnostic;DNA;DNA sequencing;Early Diagnosis;end stage liver disease;Environmental Pollution;Enzymes;experimental study;Functional disorder;Genome;genome-wide;Goals;graft vs host disease;Health Care Costs;Hospitalization;Immune response;improved;Incidence;Infection;Injury;Injury to Kidney;innovation;Kidney Diseases;Label;liver injury;Measurement;Medical;metagenomic sequencing;Metagenomics;Methylation;microorganism;minimally invasive;Modeling;Monitor;Morbidity - disease rate;mortality;multiple omics;next generation sequencing;Noise;Non-Invasive Detection;Oligonucleotides;Organ;Organ failure;organ injury;Outcome;pathogenic bacteria;pathogenic virus;Patients;Performance;Persons;Preparation;prevent;Retrospective Studies;Sampling;Sensitivity and Specificity;Sepsis;septic patients;Sodium Chloride;Specificity;Stem cell transplant;Testing;tissue injury;Tissues;treatment choice;Urinary tract infection;Work

PROJECT_TITLE: Cell-free DNA as a versatile analyte for the monitoring of sepsis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Data Science;Hematology;Microbiome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative Microbiome proﬁling can provide insight into risk and inform strategies to reduce the incidence of graft-versus-host disease, a frequent and life-threatening complication of stem cell transplantation, but there is a need for new data science approaches to untangle this complex, high-dimensional, and noisy data. We will develop new methods to improve visualization and prediction using microbiome data, along with eﬃcient and easy-to-use implementations. By applying these methods to microbiome data collected from stem cell transplant recipients, and providing free software to enable researchers to apply these methods to their own data, our work will enable new insights that will ultimately drive the development of strategies to predict and mitigate this serious complication.

PI_NAMEs: PETERSON, CHRISTINE B (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Acute leukemia;Address;Allogenic;Aplastic Anemia;Bioinformatics;Blood Cells;Bone Marrow;Cancer Center;Cancerous;Clinical;Clinical Research;cloud based;Collaborations;Complex;Complication;Computer software;computerized data processing;Data;Data Analyses;data exploration;Data Science;data visualization;Development;disorder risk;Environment;Event;flexibility;Future;Gastrointestinal tract structure;Goals;graft vs host disease;gut microbiome;Hematological Disease;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Heterogeneity;high dimensionality;immunodeficiency;improved;Incidence;Individual;Inflammatory Response;innovation;insight;interest;Intervention;Life;Linear Regressions;Methods;microbiome;microbiome composition;microbiome therapeutics;microorganism;Modeling;Multiple Myeloma;Non-Malignant;novel;Organism;Outcome;Patients;Phylogenetic Analysis;Play;Plug-in;Positioning Attribute;predictive modeling;Production;Publications;Research;Research Personnel;Resolution;Risk;risk mitigation;risk stratification;Sample Size;Sampling;Sickle Cell Anemia;side effect;Signal Transduction;Statistical Models;Stem cell transplant;study population;survival outcome;Testing;Therapeutic;Time;tool;Transplant Recipients;Treatment outcome;University of Texas M D Anderson Cancer Center;user-friendly;Variant;Visualization;Visualization software;web platform;Work

PROJECT_TITLE: New data science approaches to visualize and understand the impact of the microbiome on risk of graft-versus-host disease

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Microbiome;Nutrition

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: RELEVANCE Understanding the spatial organization of the gut microbiome can reveal crucial insights for its composition, stability, and resiliency, and improve our knowledge of its essential roles in digestion, metabolism, and immunity. This proposal aims to develop and apply new technologies for spatial metagenomics to dissect the micron-scale structure of the gut microbiome in mice models and in healthy and dysbiotic human cohorts. Findings from this study will have direct relevance for deciphering the principles governing microbial colonization of the gastrointestinal tract, which can help guide the development of clinical treatments using microbiome-based therapies.

PI_NAMEs: WANG, HARRIS H (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Adopted;Affect;Architecture;Area;Automobile Driving;Bacterial Infections;Bar Codes;Biochemical Pathway;Biological;Cecum;Cells;Cessation of life;Clinical;clinical development;Clinical Treatment;clinically relevant;clinically significant;Clostridium difficile;cohort;Colon;colon bacteria;colon microbiome;Communities;Complex;dark matter;Data;Diarrhea;dietary;Diffusion;Digestion;Disease;dysbiosis;Ecology;Ecosystem;fecal transplantation;feeding;Fiber;forest;Gastrointestinal tract structure;Generations;genome analysis;Genomics;Growth;gut bacteria;gut colonization;gut dysbiosis;gut microbes;gut microbiome;gut microbiota;Health;Healthcare;healthy volunteer;High Fat Diet;Homeostasis;Human;Human Microbiome;Immunity;improved;In Situ;Individual;Infection;innovation;insight;Intestines;Knowledge;Length;Longitudinal Studies;Maps;Measurement;Mediating;Metabolic;Metabolism;metabolomics;Metagenomics;Methods;Microbe;microbial;microbial colonization;microbiome;microbiome therapeutics;microbiota;mouse model;Mus;new technology;Nosocomial Infections;novel strategies;Outcome;particle;Particle Size;pathogen;Pathway interactions;Patients;Pattern;Persons;Plants;Play;Population;Predisposition;Process;Proliferating;Property;Protocols documentation;Recovery;Recurrence;resident commensals;resilience;Resistance;Resolution;restoration;Robotics;Role;Sampling;Shapes;single cell genomics;single cell sequencing;Small Intestines;stool sample;Structure;System;Taxonomy;Techniques;Technology;Testing;Time;whole genome;Work

PROJECT_TITLE: Micron-scale Spatial Metagenomic Mapping of Microbial Biogeography in the Gastrointestinal Tract

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


PHR: Project Narrative LINE1 (L1) retroelements are like dormant viruses that live in our genome, which are abnormally activated in patients with systemic lupus erythematosus (SLE). The proposed studies will investigate a novel hypothesis that involves the role of ORF0, a recently discovered antisense gene found in L1s, in the pathogenesis of SLE. The final goal of this proposal is to understand the importance of these “genomic parasites” in SLE, which may lead to novel diagnostic and therapeutic targets for the prevention and treatment of this severe and still incurable disease.

PI_NAMEs: ANDRADE, FELIPE  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: 5' Splice Site;5' Untranslated Regions;Address;Amino Acids;Antibodies;Antigen Targeting;Antigens;Autoantibodies;Autoantigens;Autonomous Replication;Chimeric Proteins;Clinical;clinically significant;Code;cohort;Development;Disease;DNA Transposable Elements;DNA Transposons;Elements;Endogenous Retroviruses;endonuclease;Enzyme-Linked Immunosorbent Assay;Etiology;Exons;Family;Foundations;Gene Expression Profile;Generations;Genes;Genetic Transcription;Genome;Genomic DNA;Genomics;Goals;Human;Human Genome;hybrid protein;Hybrids;Immune;immunogenicity;Immunoprecipitation;Infectious Agent;insight;interest;Interferons;Ku70 protein;L1 Elements;Length;Link;Long Terminal Repeats;Mass Spectrum Analysis;Measures;Mediating;microbial;N-terminal;neoantigens;neutrophil;new therapeutic target;novel;novel diagnostics;novel therapeutics;Nuclear;Nuclear Protein;Nucleic Acids;Nucleotides;Open Reading Frames;Outcome;Parasites;Pathogenesis;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Prevalence;Prevention;Primates;Production;promoter;prospective;Proteins;Research Project Grants;Retroelements;Retrotransposon;RNA Splicing;RNA-Binding Proteins;RNA-Directed DNA Polymerase;Role;seropositive;Signal Transduction;Source;systemic autoimmune disease;Systemic Lupus Erythematosus;Tissues;Viral;Virus;Work

PROJECT_TITLE: LINE1-ORF0 in SLE pathogenesis

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: GREENVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: EAST CAROLINA UNIVERSITY

PHR: Narrative Ataxin-1 is a protein that, when mutated, causes the neurodegenerative disorder known as spinocerebellar ataxia type 1. Recent evidence suggests that the non-mutated form of ataxin-1 takes part in numerous cellular processes including the regulation of neuronal cell proliferation, Alzheimer's disease tissue vulnerability, and the control of autoimmune response. Here, we propose to develop a novel conditional knockout mouse model which allows the study of ataxin-1 pathophysiological activity in any selected cell type and developmental stage.

PI_NAMEs: DIDONNA, ALESSANDRO  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Ablation;Address;Adopted;Adult;Alzheimer's Disease;Antigen Presentation;ataxin-1;Autoimmune;Autoimmune Responses;axon injury;B-Cell Activation;B-Lymphocytes;beta-site APP cleaving enzyme 1;Binding;Biological Process;Biology;Breeding;cancer cell;Cell Compartmentation;Cell Nucleus;Cell Physiology;Cell Proliferation;cell type;Cells;Central Nervous System;Chromatin;CNS autoimmunity;Communities;Complex;conditional knockout;Core Facility;Cre driver;Cre-LoxP;CRISPR/Cas technology;cytokine;Cytosol;Demyelinations;design;Development;Discrimination;Disease;Disease Progression;Dissection;Embryo;Enterobacteria phage P1 Cre recombinase;Enzyme-Linked Immunosorbent Assay;Epithelium;essays;Exons;Experimental Autoimmune Encephalomyelitis;Experimental Models;Female;Flow Cytometry;Funding;gain of function mutation;gene correction;Gene Targeting;Genes;genome editing;Grant;Guide RNA;Health;Heterogeneity;Hippocampus;histological stains;Immune;Immune system;Immunoglobulins;Immunohistochemistry;Immunophenotyping;immunoregulation;Implant;in vivo Model;Inflammation;intercellular communication;interest;Knock-out;Knockout Mice;Laboratories;loss of function;LoxP-flanked allele;male;Measures;Mediating;Mesenchymal;Methods;Microinjections;Modeling;Molecular;mouse genome;mouse model;Multiple Sclerosis;Mus;Mutate;Mutation;nerve stem cell;Nervous System;Neurodegenerative Disorders;neurogenesis;Neurons;North Carolina;novel;Nuclear;Organism;Outsourcing;Pathologic;Phenotype;Physiological;polyglutamine;Population;Process;programs;Proliferating;promoter;Proteins;Purkinje Cells;Regulation;Research;Resources;response;Role;Sampling;screening;Serum;Signal Transduction;single-cell RNA sequencing;Site;Spinocerebellar Ataxias;System;Technology;Tissues;tool;Transcriptional Regulation;tumorigenesis;Type 1 Spinocerebellar Ataxia;Universities;vector;Work

PROJECT_TITLE: Development of a conditional ataxin-1 knockout mouse line

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative Overall Obsessive Compulsive Disorder (OCD) is a chronic psychiatric illness that affects 2-3% of the worldwide population. This Center examines the neural network that underlie impaired behavioral flexibility, especially in the assessment of aversive outcomes, a key feature of OCD. The results from the collective studies will have relevance to several psychiatric diseases and will help optimize targets and parameters for neuromodulation as a potential therapeutic approach.

PI_NAMEs: HABER, SUZANNE N (contact)

PROGRAM_OFFICER_NAME: ZALCMAN, STEVEN J

PROJECT_TERMS: Affect;Anatomy;Animals;Anterior;Area;Aversive Stimulus;avoidance behavior;Behavior;Behavioral;behavioral impairment;Brain;Brain region;Cells;Chronic;cingulate cortex;Clinical;conventional therapy;Corpus striatum structure;cost;crosslink;Deep Brain Stimulation;Disease;Dorsal;efficacious treatment;Evaluation;experimental study;Fiber;flexibility;Focused Ultrasound;Frequencies;Functional disorder;Funding;Goals;high resolution imaging;Human;Image;Impairment;Individual;information processing;Insula of Reil;Intervention;Lesion;Link;Location;Medication Management;Mental disorders;Methods;multimodality;neural circuit;neural network;Neurons;neuroregulation;nonhuman primate;Obsession;Obsessive-Compulsive Disorder;Outcome;Pathway interactions;Patients;Physiological;Physiology;Population;Positioning Attribute;Prefrontal Cortex;Prevention therapy;Probability;Productivity;Protocols documentation;response;Rewards;Ritual compulsion;Source;Therapeutic;treatment response;ultrasound;Uncertainty;white matter

PROJECT_TITLE: Neurocircuitry of OCD: Effects of Modulation


NIH_SPENDING_CATS: Mental Health;Neurosciences

PROJECT_TERMS: Administrative Coordination;Administrator;Appointment;Area;Behavioral;Budgets;Clinical;Communication;Communities;Consultations;Corpus striatum structure;crosslink;Data;data sharing;Development;Education and Outreach;flexibility;Goals;Impairment;Individual;Information Dissemination;Institution;meetings;Mission;neural circuit;outreach;outreach program;Patients;Resource Allocation;Resource Sharing;Structure;symposium;Techniques;Therapeutic Effect;timeline;Training;Training Programs;United States National Institutes of Health;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative  Developmental defects in eye structure commonly account for visual impairment in newborns, yet we lack an understanding of the cellular dynamics and molecular pathways driving the proper formation of the eye. A compelling candidate to play a role in controlling eye formation is the complex, glycoprotein-rich extracellular matrix (ECM): mutations in certain ECM components can lead to specific structural defects in the eye that cause visual impairment in humans and model organisms. Here, our goal is to determine the mechanistic roles of specific ECM molecules in the formation and development of particular parts of the eye, using the small freshwater teleost fish Danio rerio (zebrafish), and a combination of microscopy, computational methods, and molecular genetics.

PI_NAMEs: KWAN, KRISTEN M (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Automobile Driving;Basement membrane;Biological Models;Bruch's basal membrane structure;cell behavior;Cell Death;cell motility;Cell Physiology;Cell Size;Cell Survival;Cell Transplantation;cell type;Cells;Chondroitin Sulfate A;Chondroitin Sulfate Proteoglycan;Collaborations;Coloboma;Complex;Computational Technique;Computer Analysis;Computing Methodologies;Data;Defect;Deposition;Development;Ectoderm;Embryo;Environment;epithelial stem cell;Event;experimental study;Exposure to;extracellular;Extracellular Matrix;Eye;Eye Development;eye formation;Focal Adhesions;Four-dimensional;Fresh Water;Gene Expression Profiling;Glycoproteins;Goals;Human;Image;imaging modality;Imaging Techniques;Impairment;In Vitro;in vivo;innovation;Laminin;lens;membrane assembly;Methods;Microscopy;model organism;Modeling;Molecular;molecular dynamics;Molecular Genetics;Morphogenesis;Morphology;Movement;Mutation;Neural Crest;Neural Crest Cell;Neural Retina;Newborn Infant;Nidogen;Ocular Pathology;optic cup;Optic vesicle;Optics;Organoids;Pathway interactions;Physiological;Positioning Attribute;Process;progenitor;programs;protein crosslink;Regenerative Medicine;response;Retina;Role;Series;Shapes;Signal Transduction;single cell sequencing;spatiotemporal;Structural defect;Structure;Structure of retinal pigment epithelium;teleost fish;Tenascin;Testing;timeline;Tissue Engineering;Tissue Model;Tissues;Transplantation;versican;Visual impairment;Visualization;Work;Zebrafish;zebrafish development

PROJECT_TITLE: Stepwise Coordination of Eye Morphogenesis by Extracellular Matrix

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


NIH_SPENDING_CATS: Anxiety Disorders;Biomedical Imaging;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

PROJECT_TERMS: Address;Anatomic Models;Anatomy;Anterior;Area;Behavioral;behavioral impairment;Bipolar Disorder;Brain;brain based;cingulate cortex;Classification;Complex;Corpus Callosum;Corpus striatum structure;Coupled;crosslink;Data;Diffusion Magnetic Resonance Imaging;Dorsal;Elements;experimental study;Fiber;flexibility;frontal lobe;Functional disorder;Functional Imaging;Funding;Goals;Human;human imaging;Image;imaging study;Insula of Reil;Internal Capsule;Limb structure;Link;Location;Magnetic Resonance Imaging;Maps;Methods;Modeling;neural circuit;nonhuman primate;Obsessive-Compulsive Disorder;Outcome;Output;Pathway interactions;Patients;Positioning Attribute;Prefrontal Cortex;Resolution;Rest;structural imaging;Structure;Tracer;treatment response

PROJECT_TITLE: Circuit interactions within the OCDnet