ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: ATLANTA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Heart disease and heart failure account for the most deaths among all diseases. This project investigates the molecular and electrophysiological mechanisms of hyperexcitable vasopressin neurons in heart failure. Successful completion of this project could facilitate better understanding of central nervous system involvement in heart failure and development of novel treatments.

PI_NAMEs: KIRCHNER, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Address;Affect;antagonist;Axon;Bathing;Binding;Blood Circulation;Calcium;cardiogenesis;Cardiovascular Diseases;career;career development;Career Mobility;Cause of Death;Cells;Central Nervous System;Cessation of life;Collaborations;Communication;Coupled;Coupling;Data;Dense Core Vesicle;Dependence;Development;Disease;Educational workshop;Electrophysiology (science);Endoplasmic Reticulum;Environment;Equipment;Excision;Exocytosis;experience;Feedback;Functional disorder;Generations;Goals;heart cell;Heart Diseases;Heart failure;Homeostasis;Hormones;Hyperactivity;Impairment;Institution;Laboratories;Lasers;Lead;magnocellular;Measures;Mentors;Methods;Modeling;Molecular;Monitor;N-Methylaspartate;Neurohormones;neuronal excitability;Neurons;novel;Operative Surgical Procedures;Output;paracrine;patch clamp;Patch Tests;Pathway interactions;Pattern;Peripheral;Phase;Phosphatidylinositol 4,5-Diphosphate;Physiologic pulse;Play;Postdoctoral Fellow;professor;Property;Publications;Rattus;recruit;Research;Research Personnel;response;Rodent Model;Role;Running;Shapes;Signal Pathway;Signal Transduction;skill acquisition;skills;spatiotemporal;Stereotyping;Stimulus;supraoptic nucleus;Technical Expertise;Techniques;Testing;Time;Training;Universities;Vasopressins;Vesicle;vesicular release

PROJECT_TITLE: Calcium-dependent autoregulation of vasopressin neurons in a rodent model of heart failure.


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Surgeons play a major role in the treatment of gastrointestinal (GI) diseases and it is imperative that surgeons remain at the forefront of the creation of new knowledge in the field. Given the rapidly changing approaches to biomedical research and the difficult funding environment, this T32 Program has been designed to provide the skills and experience to young surgeon-trainees so that they can pursue successful careers in surgical investigation. We are particularly focused on coalescing a faculty from a wide range of fields to bear on important GI surgical issues, such that our trainees understand the broad array of techniques and approaches available to answer clinically relevant research questions.

PI_NAMEs: HODIN, RICHARD A. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Gastrointestinal tract structure;Operative Surgical Procedures;Research Training

PROJECT_TITLE: Research Training in Alimentary Tract Surgery


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE (RELEVANCE) Complement proteins are implicated in immune hyperactivation during severe COVID-19, but underlying mechanisms are unclear. By leveraging diverse approaches in vitro and in vivo, this project explores a new role for complement membrane attack complexes (MACs) as alarmins activating inflammatory signaling. Our studies introduce a new paradigm for understanding MAC-related immunity in severe COVID-19.

PI_NAMEs: JANE-WIT, DANIEL  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: 2019-nCoV;Alveolar;Antigens;Binding;Binding Proteins;Biological Assay;Blood capillaries;Cell Death;Cell surface;cell type;Cells;Clinical;Complement;Complement Activation;Complement Membrane Attack Complex;Complex;Complication;COVID-19;COVID-19 patient;cytokine;cytokine release syndrome;Cytolysis;Data;Deposition;Diabetes Mellitus;druggable target;Edema;Endosomes;Endothelial Cells;Family;Functional disorder;GBP1 gene;guanylate;Homeostasis;Host Defense;Human;Hypertension;Immune;Immunity;improved;In Vitro;in vivo;Infection;Inflammation;Inflammation Mediators;Inflammatory;Intracellular Membranes;Life;Lung;lung injury;Mediating;Membrane;membrane assembly;Molecular;Mus;Natural Immunity;neoantigens;novel;Orthologous Gene;Outcome;Patient-Focused Outcomes;Patients;Phenotype;Process;Property;protein aggregation;protein complex;Protein Isoforms;Proteins;Proteomics;response;Role;SARS-CoV-2 antigen;SARS-CoV-2 infection;SARS-CoV-2 spike protein;sensor;Sequence Homology;severe COVID-19;Signal Transduction;soluble complement C5b-9;stem;Surface;Symptoms;Testing;tissue injury;Tissues;vascular inflammation;virtual

PROJECT_TITLE: Intracellular Membrane Attack Complexes and COVID-19 Immune Hyperactivation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-M(90)]


ORG_CITY: LEXINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative The absorption of dietary lipids and their transport to the circulation is essential for the maintenance of whole-body lipid metabolism and energy homeostasis; however, elevated postprandial plasma lipid, specifically triacylglyceride (TAG), is a significant independent risk factor for cardiovascular disease. This project will provide mechanistic insight into a newly discovered role for the protein DENND5B in the absorption of dietary TAG and its impact on cardiometabolic health. The overall objective of this proposal is to gain fundamental knowledge about the process of dietary lipid absorption by the intestine and its impact on metabolic health.

PI_NAMEs: GORDON, SCOTT M (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: absorption;Acute;Address;Affect;AGFG1 gene;Apolipoproteins B;Atherosclerosis;Autophagocytosis;Biogenesis;Bioinformatics;Body Composition;Body mass index;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cell membrane;cell type;Cells;Chylomicrons;Circulation;Co-Immunoprecipitations;Complex;Conscious;crosslink;Data;Data Set;Diet;dietary;Dietary Fats;Dyslipidemias;Enterocytes;Equilibrium;Esterification;Exhibits;exome sequencing;experimental study;Fasting;Fat-Soluble Vitamin;Fatty acid glycerol esters;Fistula;Foundations;gene network;gene regulatory network;Genes;Golgi Apparatus;Guanine Nucleotide Exchange Factors;Health;High Fat Diet;Homeostasis;Human;improved;In Vitro;Ingestion;insight;Insulin Resistance;Intestinal Absorption;intestinal epithelium;Intestinal Secretions;Intestines;Knowledge;Link;lipid metabolism;Lipids;Lipolysis;Lipoproteins;Literature;Lymph;Maintenance;Mass Spectrum Analysis;Measurement;Measures;Membrane Fusion;Metabolic;Metabolism;Methods;Mission;Mitochondria;Modeling;mouse model;Mucous Membrane;Mus;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;Obesity;Organism;particle;Particle Size;Pathway interactions;Peripheral;Plasma;Play;Process;Proteins;Publishing;Regulation;Resistance;response;Risk Factors;Role;Secretory Vesicles;single-cell RNA sequencing;Sucrose;Tissues;Tracer;trafficking;transcriptome;Transmembrane Transport;Triglycerides;United States National Institutes of Health;uptake;Variant;Very low density lipoprotein;Wild Type Mouse;Work

PROJECT_TITLE: The Role of DENND5B in Dietary Lipid Absorption

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The proposed work is basic research that aims to generate new insights into how a healthy nervous system can flexibly process reward feedback to guide effective decision-making. These studies are aligned with several constructs in the NIMH Research Domain Criteria (RDoC) and are intended to provide direct benefits to public health in the longer term, as these new insights can be used to design new ways to diagnose and treat disorders of mental health.

PI_NAMEs: GOLD, JOSHUA I (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Anterior;Arousal;awake;Basic Science;Behavior;Behavioral;Brain;Brain Stem;Cell Nucleus;Cerebral hemisphere;cingulate cortex;Cognition;Cognitive;Complex;Data;Data Set;Decision Making;design;Diagnosis;Diameter;Electroencephalography;Etiology;Event;experience;Feedback;flexibility;Foundations;Functional disorder;Goals;Individual;information processing;innovation;insight;interest;Link;locus ceruleus structure;Measurement;Measures;Medial;Mediating;Mental disorders;Modeling;Monitor;Monkeys;Motor;Motor Neurons;National Institute of Mental Health;Nervous System;neural;Neuromodulator;Neurons;neuroregulation;Norepinephrine;novel;Output;Pathway interactions;Pattern;Performance;pharmacologic;Play;Population;Population Process;Process;Public Health;Pupil;Research Domain Criteria;Resolution;Rest;Rewards;Role;Sensory;Signal Transduction;Source;Specificity;Structure;Surface;System;Task Performances;Testing;theories;Time;Training;Uncertainty;Work

PROJECT_TITLE: LC-ACC interactions supporting adaptive, feedback-driven decisions

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PUBLIC HEALTH RELEVANCE: United World Antiviral Research Network (UWARN) will address emerging and re-emerging infectious diseases by carrying out research on arboviruses, viruses transmitted by arthropods to humans, with collaborating partner research laboratories in Brazil, Pakistan, Senegal, South Africa and Taiwan. The research will develop innovative new diagnostic reagents, namely human viral-neutralizing antibodies and designed proteins that release light when antibodies to virus are present in blood. UWARN research will also improve understanding of how viruses manipulate the human immune system, facilitating development of better biomarkers to predict severe disease as well as host-directed therapies that could improve outcomes of viral infection.

PI_NAMEs: GALE, MICHAEL ;RABINOWITZ, PETER MACGARR;VAN VOORHIS, WESLEY C (contact);WASSERHEIT, JUDITH N.

PROGRAM_OFFICER_NAME: WOODSON, SARA ELAINE

PROJECT_TERMS: Acute;Administrative Coordination;Alpha Virus;Animals;antagonist;Antibodies;arboviral disease;Arbovirus Infections;Arboviruses;Area;Arthropod Vectors;arthropod-borne;Bacteriology;Binding;biobank;Biological Assay;Biological Markers;Blood;Body Fluids;Brazil;candidate identification;candidate marker;Cell Separation;chikungunya;Chikungunya virus;Clinical;Clinical Management;Clinical Trials;cohort;Collaborations;Collection;Containment;Crimean Hemorrhagic Fever;cross reactivity;Data;data management;Dengue;Dengue Infection;Dengue Virus;design;Detection;Development;Diagnosis;Diagnostic;Diagnostic Reagent;Disease;Emergency Situation;Emerging Communicable Diseases;Emerging infection;emerging virus;Engineering;Enzyme-Linked Immunosorbent Assay;Epitopes;experience;Far East;Fever;Flavivirus;Fluorescence;Future;Genomic approach;global health;global health emergency;Human;human monoclonal antibodies;Immune response;Immune system;Immunoglobulin G;immunoregulation;improved;improved outcome;Individual;Infection;Infectious disease threat;Infectious Diseases Research;Innate Immune Response;Innate Immune System;innovation;Institution;International;Intervention;Investigation;Japanese Encephalitis;Knowledge;Laboratories;Laboratory Research;Light;Maps;Measurement;Metagenomics;Microcephaly;Molecular;Monitor;Monoclonal Antibodies;Natural Immunity;neutralizing antibody;neutralizing monoclonal antibodies;next generation sequencing;novel;novel diagnostics;novel strategies;Oropouche virus;Orthobunyavirus;Outcome;Pakistan;pandemic preparedness;Parasitic infection;pathogen;Pathogenesis;pathogenic virus;Pathway interactions;Patients;point of care;Population;population based;Prevalence;Process;Production;prospective;Protein Engineering;Proteins;public health relevance;Reagent;Research;Resources;Rift Valley Fever;Risk;Sampling;Senegal;Sensitivity and Specificity;Serology;Seroprevalences;severe dengue;Site;South Africa;South America;Specimen;Statistical Data Interpretation;System;Taiwan;Technology;Technology Transfer;Testing;The science of Mycology;Therapeutic;therapeutic target;Time;transcriptomics;Universities;Variant;Veterinarians;Viral;Viral Antibodies;viral detection;Viral Hemorrhagic Fevers;Viral Load result;viral transmission;Viral Vaccines;virology;Virus;Virus Diseases;Washington;Yellow Fever;ZIKA;Zika Virus

PROJECT_TITLE: University of Washington Arboviral Research Network (UWARN)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: ARLINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

ORG_STATE: TX

PHR: Narrative Mycobacterium tuberculosis infections require long and onerous treatment: antibiotic regimens that could clear infections more quickly would improve patient outcomes. This proposal seeks to determine how Mtb battens down the hatches of its cell wall during stress, thus increasing antibiotic tolerance. This work will characterize some of the molecular mechanisms responsible for treatment recalcitrance in Mtb, and will lay the foundation for future screens for anti-tolerance drugs.

PI_NAMEs: BOUTTE, CARA CHENEY (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Affect;antibiotic tolerance;Antibiotics;Binding;biological adaptation to stress;Cell model;Cell Polarity;Cell Wall;Data;Dependence;design;drug candidate;Drug Controls;Drug Screening;Drug Targeting;Drug Tolerance;effective therapy;Effectiveness;Enzyme Precursors;Enzymes;Event;Foundations;Future;genetic regulatory protein;Genus Mycobacterium;Goals;Growth;hatching;improved;In Vitro;Infection;Left;Measures;men;Metabolic;Metabolism;Modeling;Molecular;molecular modeling;mycobacterial;Mycobacterium smegmatis;Mycobacterium tuberculosis;novel therapeutics;Outcome;Patient-Focused Outcomes;Peptidoglycan;Permeability;Pharmaceutical Preparations;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Process;Protein Dephosphorylation;Protein Isoforms;Proteins;Recycling;Regimen;Regulation;Research;Role;Signal Pathway;Signal Transduction;Signaling Protein;Site;Stress;Testing;treatment strategy;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Work

PROJECT_TITLE: Control of cell wall synthesis and antibiotic tolerance in mycobacteria

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative: The proposed research will define the cellular biology of the oxysterol-binding protein (OSBP) in viral proliferation. OSBP has been identified as a critical mediator in the replication of RNA pathogenic viruses, including coronaviruses. These viruses are a major cause of human sickness and mortality, and therefore the proposed research is relevant to public health and relevant to the NIH's mission of reducing illness and disability.

PI_NAMEs: BURGETT, ANTHONY WG (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: 2019-nCoV;Alternative Splicing;Anti-viral Response;antiviral drug development;antiviral immunity;Autophagocytosis;Biological;Biology;Cell Physiology;Cells;Cellular biology;Chemicals;cholesterol-binding protein;Complex;Coronavirus;Coronavirus Infections;COVID-19 pandemic;Dengue Virus;design;disability;Disease;Dose;drug development;Drug Targeting;Enterovirus;Eukaryotic Cell;Family;Family Picornaviridae;Flavivirus;Foundations;Future;Generations;Goals;Hepatitis C;Human;human pathogen;Individual;Infection;Innate Immune Response;insight;Lipids;Mediating;Mediator;Membrane;Messenger RNA;Mission;Modality;Modeling;Morphology;mortality;nanomolar;Nonsense-Mediated Decay;novel virus;oxysterol binding protein;pathogenic virus;Pathogenicity;Pathway interactions;Process;Program Development;Proliferating;prophylactic;protein function;Proteins;Public Health;Publications;Publishing;Reporting;Repression;Research;response;Rhinovirus;RNA;RNA replication;RNA Viruses;Role;sensor;small molecule;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic lead compound;Translations;United States National Institutes of Health;Viral;Viral Physiology;Viral Proteins;Virus;Virus Diseases;Virus Replication;Work;Zika Virus

PROJECT_TITLE: Cellular Mechanism of Oxysterol-Binding Protein (OSBP) in Viral Proliferation: A Chemical Biology Approach

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_CITY: WASHINGTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: NARRATIVE  Current understanding of T cell response to a high antigen load in tumor microenvironment is incomplete. In addition, there is an unmet need to improve responses and the numbers of patients who benefit from the current anticancer immunotherapies. By focusing on a previously unappreciated regulator of antitumor immunity, our proposed study could inform ways to improve efficacy of anticancer immunotherapy.

PI_NAMEs: HU, YANFEN ;LI, RONG  (contact);ZHANG, NU

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Address;Animal Model;antigen-specific T cells;Antigens;Attenuated;Biology;cancer immunotherapy;cancer infiltrating T cells;cancer type;CD8-Positive T-Lymphocytes;Cell Nucleus;Cell Physiology;Cellular immunotherapy;chimeric antigen receptor T cells;Clinical;Cues;Cytoplasm;Data;Development;effector T cell;Epigenetic Process;exhaust;exhaustion;Genetic Transcription;humanized mouse;Immune;immune checkpoint blockade;Immune Evasion;immunoregulation;improved;Infiltration;insight;Knock-out;Knowledge;Lymph Node Drainage;Mediating;Memory;Microscopy;Modeling;Molecular;mouse model;multidisciplinary;Mus;Mutagenesis;negative elongation factor;neoplasm immunotherapy;novel;novel strategies;novel therapeutics;Nuclear;overexpression;Patients;Physiological;Polymerase;Positioning Attribute;programs;Protein Complex Subunit;protein degradation;Publishing;receptor;Receptor Signaling;Reporting;Research Design;Resolution;response;RNA Polymerase II;Role;Signal Transduction;Signaling Molecule;System;T cell regulation;T cell response;T memory cell;T-Cell Receptor;T-Lymphocyte;Testing;tool;Transcription Initiation Site;Transcriptional Activation;Transcriptional Regulation;Treatment Efficacy;tumor;Tumor Antigens;Tumor Immunity;tumor immunology;tumor microenvironment;Tumor Promotion;Tumor-Infiltrating Lymphocytes;Work;ZAP-70 Gene

PROJECT_TITLE: A Novel Regulator of Antitumor Immunity and Immunotherapy

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Chronic Pain;Dental, Oral, and Craniofacial Disease;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE  There is a desperate need for efficacious, safe and misuse free analgesics. Based on its understudied nature, druggability and known association with pain modulation, we will explore the plausibility of the GCH1 gene product GTP Cyclohydrolase 1 as a target for treating chronic orofacial pain.

PI_NAMEs: AYAZ, BASAK ;MURPHY, NIALL P (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Analgesics;Animal Model;animal pain;Animals;Behavior;Brain;Brain region;cancer pain;Catecholamines;central pain;Chronic;chronic constriction injury;chronic pain;chronic pain management;chronic painful condition;cofactor;conditioned place preference;Data;Development;DNA Sequence Alteration;Dopamine;Enzymes;Epinephrine;Gene Expression;gene product;Genes;global health;Goals;GTP Cyclohydrolase;Health Care Costs;Health Expenditures;Healthcare;Human;inflammatory pain;inhibitor;Link;Maintenance;Measurable;Methods;Molecular Target;monoamine;Nature;Nerve;nerve injury;Neurotransmitters;Nitric Oxide;Norepinephrine;novel;orofacial;Orofacial Pain;Pain;Pain Free;Pain management;Pain Management Method;Pain Measurement;pain model;pain perception;pain relief;painful neuropathy;Pathogenesis;Pathway interactions;Patients;Peripheral Nervous System;Pharmaceutical Preparations;Production;Property;Quality of life;Rattus;response;Rewards;Rodent;Role;sciatic nerve injury;Serotonin;Structure of trigeminal ganglion;Testing;tetrahydrobiopterin;treatment strategy;Visceral pain

PROJECT_TITLE: Targeting GTP Cyclohydrolase 1 for treating chronic orofacial pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 DPI-7 (03)]


NIH_SPENDING_CATS: Chronic Pain;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects

PHR: NARRATIVE  The role of aGPCRs in chronic pain is unexplored. This project evaluates the function of the aGPCR ADGRD1 in a mouse model of neuropathic pain to determine if this protein is a potential therapeutic target.

PI_NAMEs: AYAZ, BASAK ;CAUDLE, ROBERT M (contact)

PROJECT_TERMS: Address;Adenylate Cyclase;Adhesions;Afferent Neurons;Agonist;allodynia;Amino Acids;Analgesics;Animals;Axon;Behavior;Behavioral;Binding;Binding Sites;Biological Assay;botulinum;Botulinum Toxins;Cell Physiology;cell type;Cells;Chronic;chronic constriction injury;chronic neuropathic pain;chronic pain;Cyclic AMP;Data;design;Development;Devices;Drug Design;Eligibility Determination;experience;experimental study;Face;Future;G-Protein-Coupled Receptors;Gene Expression;Genome;GTP-Binding Protein alpha Subunits, Gs;GTP-Binding Proteins;Harvest;Human;Hyperactivity;Immunohistochemistry;In Situ;in vivo;Lesion;Ligands;Light;Location;mechanical allodynia;Mediator;Membrane;Modeling;Molecular;Molecular Conformation;mouse model;Mus;myelination;N-terminal;Nerve;nerve injury;Neurons;Neuropeptides;new therapeutic target;Nociception;Nociceptors;novel;orofacial;Orofacial Pain;Pain;Pain management;Pain Measurement;painful neuropathy;Peptides;Probability;Production;protein activation;protein expression;Proteins;Proteolysis;Rattus;receptor;Receptor Activation;receptor internalization;Reporting;Research Design;Role;Schwann Cells;Series;single-cell RNA sequencing;Source;Structure;Structure of trigeminal ganglion;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Time;Tissues;tool;Toxin Conjugates;transcriptome;transcriptome sequencing;transcriptomics;Trigeminal subnucleus caudalis;Up-Regulation;uptake

PROJECT_TITLE: Role of Understudied aGPCRs in Orofacial Neuropathic Pain


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SACRAMENTO

ORG_DEPT: BIOLOGY

ORG_NAME: CALIFORNIA STATE UNIVERSITY SACRAMENTO

ORG_STATE: CA

PHR: U-RISE at Sacramento State Program Narrative Even after decades of efforts to increase diversity and inclusion in the sciences, technological, engineering, and mathematics (STEM) fields, national data continue to show low representation of individuals from diverse ethnic and racial groups in the workforce. In addition, the low retention and proportion of degrees awarded to individuals from historically underrepresented and marginalized groups directly affect the Nation’s ability to produce a diverse and inclusive STEM workforce. U-RISE at Sacramento State will contribute to addressing these concerns by training talented students from groups historically excluded in the sciences for success, service and leadership, while increasing the number of individuals from underrepresented groups who pursue graduate degrees as biomedical scientists.

PI_NAMEs: GONZALEZ-ORTA, ENID T (contact);QUINONES-SOTO, SEMARHY

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Admission activity;Biomedical Research;Biotechnology;college;design;Disabled Persons;Doctor of Philosophy;Doctor's Degree;Educational Curriculum;Educational workshop;Ethnic Population;Exclusion;experience;Generations;Goals;Graduate Degree;graduate school;hands on research;Low Income Population;marginalized population;Mathematics;Natural Sciences;programs;racial population;Readiness;Research;Research Personnel;Research Training;responsible research conduct;Science;skills;Students;Talents;Training;Training Activity;Underrepresented Populations;Underrepresented Students;Work

PROJECT_TITLE: U-RISE at Sacramento State

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative This proposal requests a new small-animal positron emission and computed tomography (PET/CT) to support translational, disease-focused, and basic science molecular imaging research at Emory University. The current Inveon PET/CT system at Emory University is obsolete and at high risk of becoming inoperable due to service and parts discontinuation of the manufacturer. The new system will be operated and managed through the Center for Systems Imaging Core and continues to support innovative and NIH-funded preclinical molecular imaging development in the study of neurology, cardiology, oncology and infectious diseases in the greater Atlanta area.

PI_NAMEs: LIANG, STEVEN H (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Animals;Area;Beds;Binding Proteins;Biochemical Process;Biological Process;biomedical imaging;Blood flow;Body Temperature;Brain;Cardiac;Cardiovascular Diseases;Clinical;Communicable Diseases;Communities;Core Facility;cost;Cyclotrons;Detection;Emerging Technologies;experience;Faculty;Funding;high risk;Image;imaging approach;imaging platform;imaging system;improved;in vivo;innovation;Institution;instrument;Interdisciplinary Study;Laboratories;Ligands;Malignant Neoplasms;Manufacturer;Measures;Medical;Metabolism;meter;molecular imaging;Mus;Neurodegenerative Disorders;new technology;Performance;PET/CT scan;Physics;Physiologic Monitoring;Positron-Emission Tomography;pre-clinical;Radioactive;Radiochemistry;Rattus;receptor density;Request for Proposals;Research;Research Personnel;Research Project Grants;Resolution;Resources;respiratory;Services;Site;success;System;Techniques;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: micro-PET/CT system for preclinical molecular imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-M (30)]


NIH_SPENDING_CATS: Pediatric

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Our NIDDK T32 Training Program “Developing Pediatric Endocrinologists and Diabetes Psychologists for the Future” will be conducted at the Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine and Children’s Hospital Colorado, Anschutz Medical Campus. Our PRINCIPAL OBJECTIVE is to develop Pediatric Endocrinologists and Psychologists who are well grounded in basic and/or translational science research skills required for advancing the field of knowledge in type 1 and type 2 diabetes and are educated in collaborative and integrated approaches for translating basic discoveries in diabetes into opportunities for advancing clinical research and care. Our OVERALL GOAL is that after their training, our trainees will have acquired the professional skills to become clinician scientists beginning productive academic careers as junior faculty investigators who will have the leadership capacity to make significant impacts in the fields of type 1 and type 2 diabetes in children and adolescents.

PI_NAMEs: STECK, ANDREA  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Childhood;Endocrinologist;Future

PROJECT_TITLE: Developing Pediatric Endocrinologist for the Future

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ORG_CITY: BIRMINGHAM

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: RELEVANCE Addressing the decline in the number of physician-scientists, including surgeon-scientists, remains essential to future research discoveries to improve patient outcomes. Mentored early research training experiences influence career choices and increase the likelihood of trainees to pursue medical careers in research. The University of Alabama at Birmingham Short-Term Research Experiences Advancing Medical Students (STREAMS) provides mentored summer research opportunities as a mechanism to encourage medical students to pursue academic careers with a research component.

PI_NAMEs: CHEN, HERBERT  (contact);LOCKE, JAYME ELIZABETH

PROJECT_TERMS: Address;Alabama;Area;Award;career;Career Choice;Deep South;Environment;Ethnic Population;experience;Exposure to;Fellowship;Funding;Future;Goals;Health Disparities Research;Institution;interest;journal article;Leadership;Manuscripts;medical schools;Medical Students;Medicine;meetings;Mentors;Mentorship;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Physicians;Process;Productivity;programs;Publishing;racial population;Reporting;Research;Resources;role model;Scientist;Students;success;summer research;Surgeon;symposium;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: Short Term Research Experiences Advancing Medical Students (STREAMS)

STUDY_SECTION_NAME: Fellowships in Kidney, Urology, and Hematology[DDK-G]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative Bidirectional crosstalk between sensory neurons and immune cells is central for integrating a wide range of signals, promoting responses against noxious stimuli while preventing exacerbated responses against benign stimuli. Dysregulation of this balance can lead to maladaptive responses culminating in chronic conditions involving inflammation, pain and itch. This study seeks to probe neuro-immune interactions that promote tissue homeostasis, which may result in novel therapies for chronic conditions involving pain, itch and inflammation.

PI_NAMEs: MENDOZA, ALEJANDRA  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TITLE: Regulation of inflammation by nociception


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Musculoskeletal diseases are some of the most common reasons why people of all ages visit a doctor and are leading causes of disability around the globe. In the United States, 1 of every 7 people reports a musculoskeletal impairment and musculoskeletal conditions cost our society an estimated $269.3B every year. The prevalence of musculoskeletal conditions will continue to escalate in the next 20 years as the population ages. This trans- disciplinary program provides focused training to a new generation of biomedical researchers and physicians who will advance the science and treatment of arthritis and musculoskeletal diseases.

PI_NAMEs: WESTENDORF, JENNIFER J (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TITLE: Musculoskeletal Research Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 SP (M1)]


PHR: PROJECT NARRATIVE Liver disease affects nearly one in three Americans and a billion people worldwide. The purpose of this grant is to provide training to physicians and other scientists to pursue basic, translational and clinical research into the causes of the various forms of liver disease and to develop new and more effective treatments.

PI_NAMEs: NATHANSON, MICHAEL H (contact)

PROJECT_TERMS: Hepatology;Training Programs

PROJECT_TITLE: Training Program in Investigative Hepatology

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-W (J1)]


NIH_SPENDING_CATS: Mental Health;Pediatric

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Research innovations in the field of child mental health conducted by specially trained clinician- scientists are desperately needed to adequately respond to the unprecedented youth mental health crisis in the United States. This T32 training program will build upon previous success in recruiting, engaging, and mentoring a diverse group of scientists who can advance the field in order to reduce the burden of child mental disorders. The program is designed to target current priorities in child mental health research, including: improving our understanding of pathogenesis, course and treatment of child mental health disorders; enhancing health equity; utilizing technological advances to enhance knowledge and care; and partnering with communities in the conduct of research.

PI_NAMEs: GOLDSTEIN, TINA R (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: adolescent mental health;Child;Research

PROJECT_TITLE: Child & Adolescent Mental Health Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (04)]


ADMINISTERING_IC: NS

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Pain;Neurosciences;Pain Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Women's Health Research

ORG_CITY: Boston

ORG_NAME: TUFTS UNIVERSITY MEDFORD

PHR: PROJECT NARRATIVE Neither conventional preclinical models using rodents nor simple human stem cell models using pain-sensing nociceptors capture the complexity of human pain circuits. This hampers the discovery of solutions for treatment of chronic pain, which may potentially target multiple cell types (including both neurons and supporting glia), localized cell populations with distinct positional identities and/or the environment where these pain networks reside. This proposal will develop advanced human stem cell tools that will establish region- specific cells, circuits, and tissues, enhancing our fundamental understanding of human pain networks along the body axis and accelerating the creation of accurate models that can be used for high throughput drug screening.

PI_NAMEs: IYER, NISHA  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: 3-Dimensional;Acceleration;Afferent Neurons;Analgesics;Award;Biological Models;breast cancer metastasis;cell type;Cells;Central Nervous System;Characteristics;chronic pain management;Disease;drug development;endometriosis;Environment;Exhibits;Goals;Health;high throughput screening;high-throughput drug screening;Human;human pluripotent stem cell;human stem cells;Immune;in vivo;interest;Investigation;Methods;model development;Modeling;multidisciplinary;nerve supply;Nervous System Disorder;Neuroglia;Neurons;Nociceptors;novel therapeutics;Organ;Organoids;Pain;pain perception;Pain Research;pain sensation;pain signal;Peripheral;Population;pre-clinical;Pre-Clinical Model;Regenerative Medicine;Research Personnel;Rodent;Rodent Model;Signal Pathway;somatosensory;Specificity;Spinal Cord;stem cell model;stem cells;Study models;Technology;Tissue Engineering;Tissues;tool;Women's Health

PROJECT_TITLE: Developing Human Pluripotent Stem Cell Tools for Region-Specific Pain Circuits


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Multiple Sclerosis;Neurodegenerative;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Autoimmune disorders affect millions of people worldwide and impose a significant burden on society, given the age groups they affect and their chronic nature. Current treatments either do not impact certain autoimmune diseases or are associated with significant adverse effects due to eliminating both pathogenic and protective immune cells. The Johns Hopkins Autoimmunity Center of Excellence will perform clinical trials in patients with multiple sclerosis and myositis, in addition to a collaborative project in participants with neuromyelitis optica (NMO) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) with the goal of improving our understanding of the specific immune cell subsets driving these disease processes and ultimately identifying novel targeted treatment approaches for autoimmunity.

PI_NAMEs: PAIK, JULIE JISUN (contact)

PROGRAM_OFFICER_NAME: FERGUSON, STACY E

PROJECT_TERMS: Accreditation;Administrative Coordination;Adverse effects;Affect;age group;Agreement;American;anti-CD20;Antibodies;Autoantibodies;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;Automobile Driving;B-Lymphocytes;biobank;Biological Markers;Cells;Cerebrospinal Fluid;Chronic;Clinical;Clinical Research;Clinical Trials;Collaborations;college;Complex;Discipline;Disease;Disease remission;disorder subtype;Double-blind trial;Ecosystem;Ensure;Exclusion;experience;Funding;Generations;Goals;Image;Immune;immune function;Immunoglobulin Class Switching;Immunologics;Immunosuppression;improved;Inclusion Body Myositis;Inflammation;Inflammatory;Infrastructure;innovation;Institution;interdisciplinary collaboration;Kv1.3 potassium channel;Leadership;Literature;Longitudinal cohort;Memory B-Lymphocyte;Microglia;Modification;Multiple Sclerosis;multiple sclerosis patient;Myositis;Nature;neuroimmunology;Neuromyelitis Optica;novel;novel therapeutics;oligodendrocyte-myelin glycoprotein;Outcome;Participant;Pathogenesis;Pathogenicity;Pathology;Patient Care;patient oriented;Patient Recruitments;peripheral blood;Persons;Phase;Phenotype;Polymyositis;precision medicine;Precision Medicine Initiative;Process;Randomized;Recurrent disease;Research;Research Personnel;Research Project Grants;Resources;Rheumatology;Sampling;Secondary Progressive Multiple Sclerosis;Societies;synergism;T memory cell;targeted treatment;Testing;Therapeutic;Therapeutic Agents;Therapeutic Clinical Trial;Therapeutic Trials;treatment strategy

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 KGH-I (J1)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Drug use is the leading cause of preventable death in the United States. There is an urgent national need to equip the next generation of predoctoral addiction researchers with the expertise, tools, and techniques necessary to advance discovery science and accelerate development of therapeutics to address drug addiction. This grant describes a robust interdisciplinary training program, TRAIN@wayne, uniquely focused on the translational study of addiction neurobiology and exposure to state-of-the-art research methods and rigorous experimental design, complemented by robust career development and individualized mentorship.

PI_NAMEs: CONTI, ALANA C.;GREENWALD, MARK K (contact);LEDGERWOOD, DAVID M

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TITLE: TRAIN@wayne: Translational Research in Addiction and Integrative Neuroscience

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Narrative For a complex organ like heart that harbors large number of different cell types, a coordinated communication between individual cells is of paramount importance for efficient functioning of the heart. Extracellular vesicles or exosomes, small vesicles secreted by most cells are important mediator of cell to cell communication both within heart and with other cells/organs at long distance. This program will comprehensively characterize how after heart injury individual cell- derived exosomes communicate with other cells in heart and at long distance and how these communications affect overall heart repair after injury and hopefully will identify new mechanisms and therapeutic targets to enhance heart repair.

PI_NAMEs: KISHORE, RAJ  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Adipocytes;Adipose tissue;ADRBK1 gene;Adrenergic Agents;Affect;angiogenesis;beta-2 Adrenergic Receptors;Biochemical;Biology;Bone Marrow;Cardiac;Cardiac Myocytes;cardiac repair;Cell Communication;cell injury;Cell model;Cell Physiology;cell type;Cells;Communication;Complex;design;Diameter;Disease;Distal;Distant;endothelial stem cell;Endothelium;Event;exosome;extracellular vesicles;G protein coupled receptor kinase;Goals;healing;Heart;heart damage;heart function;Heart Injuries;Homeostasis;improved;Individual;injured;Injury;injury and repair;intercellular communication;Ischemia;Link;Lipids;Macrophage;Mediating;Mediator;MicroRNAs;Molecular;mouse model;Myeloid Cells;Myocardial;myocardial injury;Myocardium;neovascularization;new therapeutic target;novel;Organ;paracrine;Phenotype;Phosphotransferases;Physiological;Process;programs;Property;Proteins;Regulation;repaired;response;response to injury;Role;Science;Scientist;Signal Transduction;stem cell function;Stimulus;Stress;stressor;Structure;synergism;Techniques;Testing;therapeutic target;tissue repair;Untranslated RNA;Vesicle

PROJECT_TITLE: Exosomes as mediators of cardiac injury and repair

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP (JA)]


PHR: Core A: Narrative This administrative core is essential for the coordination of Program Projects and dissemination of information to the public. The Core serves a vital role in the ongoing success of the Program and is the front line of networking between the multiple facets of the Program.

PROJECT_TERMS: Accounting;Advisory Committees;Annual Reports;Biocompatible Materials;Budgets;cardiac repair;Cardiovascular system;Collaborations;Committee Members;Communication;cost;data sharing;Equipment;exosome;Expenditure;experience;Grant;Guidelines;hatching;Heart Injuries;Individual;Information Dissemination;Institution;Laboratories;Legal patent;Manuscripts;Mediation;Mediator;medical schools;meetings;Minor;National Heart, Lung, and Blood Institute;Occupational activity of managing finances;Office Management;Participant;Periodicals;Preparation;Principal Investigator;Productivity;Program Research Project Grants;programs;Progress Reports;Protocols documentation;Publications;Reagent;Records;Research Personnel;Role;Schedule;Science;success;Technology Transfer;translational medicine;Travel;United States National Institutes of Health;University adminstration;Vendor;Vertebrates;Work

PROJECT_TITLE: Admin Core


PHR: PROJECT NARRATIVE Exosome are tiny vesicles secreted by most cardiac cells and are key mediators of cell to cell communication by transferring donor cell molecular cargo to recipient cells. Exosome are loaded with proteins, mRNAs and microRNAs that are specific to the parent cells and regulate molecular processes once delivered to target cell types. Therefore this core is essential for isolation, characterization, and analysis of exosome contents from different sources that will be utilized by all three scientific projects.

PROJECT_TERMS: Bioinformatics;Biological;Cardiac;cardiac repair;Cardiovascular system;Cell Communication;cell type;Cells;Collaborations;Core Facility;Data Set;design;education research;Electron Microscope;Ensure;Equipment;Equity;exosome;Flow Cytometry;Fox Chase Cancer Center;Funding;Generations;Goals;Heart Injuries;Human;Individual;light scattering;Mediator;Medical Education;medical schools;Messenger RNA;MicroRNAs;Molecular;Molecular Analysis;Mus;Parents;Physiology;Plasma;Procedures;Process;Production;programs;Proteins;Quality Control;Research;Research Personnel;Resources;Role;Sampling;Services;Source;synergism;Training;translational medicine;Universities;Vesicle

PROJECT_TITLE: Core B


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

PHR: PROJECT NARRATIVE The goal of the Physiology and Surgical Core (Core C) is to support all projects by providing expertise to carry out numerous experimental approaches to examine cardiac physiology and pathology in the intact animal. These services will provide the backbone for the major focus of this Program Project Grant to determine exosome-mediated cell-cell communication both locally within the injured myocardium and distally with other organs and how these intracellular and inter-organ communications influence overall myocardial responses to injury and the repair process. Understanding these very important processes we hope will lead to the development of new treatments for heart disease.

PI_NAMEs: ELROD, JOHN WILLIAM (contact)

PROJECT_TERMS: Animals;Area;Blinded;Capsid;Cardiac;cardiac repair;Cell Communication;Cells;Collaborations;collaborative environment;Communication;Consultations;Coronary artery;Data;Data Analyses;data platform;Dedications;design;Development;Distal;Distant;exosome;experience;Experimental Designs;experimental study;Genes;genetic manipulation;Goals;Heart;Heart Diseases;Heart failure;heart function;Heart Injuries;hemodynamics;in vivo;in vivo Model;Infrastructure;Injections;injured;Injury;injury and repair;Intravenous;Investigation;ischemic injury;Left;Ligation;Mediating;Mediator;Messenger RNA;Methodology;MicroRNAs;Modeling;Molecular;Monitor;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardial Reperfusion Injury;Myocardium;Nodal;Operative Surgical Procedures;Organ;Outcome;Outcome Assessment;paracrine;particle;Pathology;Pathway interactions;Phenotype;Physiology;Play;Population;pressure;Process;Productivity;Program Development;Program Research Project Grants;programs;Protocols documentation;Randomized;Relaxation;repaired;Reperfusion Injury;Reporting;Reproducibility;Research Design;Research Personnel;Resolution;Resources;response to injury;RNA;Services;Signal Transduction;stem cell therapy;Structure;success;Surgical Models;synergism;Systemic blood pressure;Techniques;Testing;Therapeutic;Tissues;Two-Dimensional Echocardiography;Variant;Ventricular;Vertebral column;Viral

PROJECT_TITLE: Core C


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Narrative Cell-cell communication is key component of cardiac injury and repair. This project aims to understand the role of extracellular vesicles from injured cardiac muscle cells in communicating with resident endothelial cells and bone marrow progenitor cells and the consequence of this communication on the angiogenesis after myocardial infarction. Data obtained from proposed studies may potentially be crucial in understanding new mechanisms of ischemic heart injury and repair processes and potentially identification of new therapeutic targets.

PROJECT_TERMS: Acute myocardial infarction;Affect;Anatomy;angiogenesis;Angiogenesis Inhibition;Angiogenesis Inhibitors;Animals;Biological Markers;Biology;Blood capillaries;Blood Vessels;Bone Marrow;Cardiac;cardiac angiogenesis;Cardiac Myocytes;cardiac repair;Cell Communication;Cell Physiology;Cell Separation;Cell Therapy;Cells;Cellular biology;Cessation of life;Communication;Coronary;Data;Development;Distal;Distant;early phase clinical trial;Endothelial Cells;Endothelium;exosome;experimental study;extracellular vesicles;Functional disorder;gain of function;Heart;Heart Diseases;Heart failure;heart function;Heart Injuries;Impairment;improved;Infarction;Injury;injury and repair;insight;ischemic injury;Knockout Mice;Left;limb ischemia;Link;loss of function;Mediating;Mediator;Microcirculation;MicroRNAs;Modeling;Molecular;Mus;Muscle;Myocardial Infarction;myocardial injury;Myocardial Ischemia;nemo-like kinase;neovascularization;new therapeutic target;overexpression;Pathologic;Patients;Perfusion;Phenotype;Physiological;Plasma;pre-clinical;precursor cell;prevent;Process;Property;repair function;Repression;Role;Signal Induction;Signal Transduction;SOX6 gene;stem cells;Stress;Testing;transcription factor;Treatment Efficacy;vascular injury;Ventricular

PROJECT_TITLE: Project 1


PHR: Project 2 (Koch) Narrative (relevance): Elucidating novel roles for GRK2 and adrenergic regulation of secreted extra-cellular vesicles (EVs) and exosomes from myocytes and how this leads to changes in the secretome during heart failure and metabolic disorders will be critical to gain increased understanding of these disease processes. It is clear that the cardiac secretome (signals/factors released from the heart) can affect neighboring heart cells as well as distant organs such as fat cells and some of these crucial factors are packaged in EV/exosomes and levels of GRK2, which can be induced by stressors including ischemia and high fat diet, can alter what is secreted. Working with this PPG group will lead to elucidation of novel communicative signals between heart and fat that can lead to novel therapeutic targets not only for heart failure but also potentially for obesity.

PI_NAMEs: KOCH, WALTER J. (contact)

PROJECT_TERMS: Acute;adipocyte differentiation;Adipocytes;Adipose tissue;Adrenergic Agents;Affect;aorta constriction;beta-adrenergic receptor;Cardiac;Cardiac Myocytes;cardiac repair;Cardiovascular system;Catecholamines;Cell Communication;Cell Differentiation process;Cells;Chronic;Collaborations;combat;Communication;Data;desensitization;Development;Disease;Distant;Endocrine;exosome;experimental study;extracellular vesicles;Fatty acid glycerol esters;feeding;Functional disorder;Funding;G protein coupled receptor kinase;G-Protein-Coupled Receptors;Grant;Heart;heart cell;Heart failure;heart function;Heart Injuries;High Fat Diet;In Vitro;in vivo;inhibitor;Injury;injury and repair;Ischemia;ischemic injury;Knockout Mice;Mediating;Mediator;Metabolic Diseases;MicroRNAs;Mus;Muscle Cells;Myocardial;Myocardial dysfunction;Myocardial Infarction;myocardial injury;Myocardial tissue;Myocardium;new therapeutic target;novel;Obesity;Organ;overexpression;paracrine;Pathogenicity;Pathway interactions;Peptides;Phenotype;pressure;Process;Proteins;Publishing;Regulation;release factor;Research;response;Role;Science;Serum;sex;Signal Transduction;Stress;stressor;Sympathetic Nervous System;Testing;Thinness;Tissues;Toxic effect;Transgenic Mice;translational approach;Up-Regulation;Wild Type Mouse

PROJECT_TITLE: Project 2


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

PHR: Narrative Acute ischemic injury, such as myocardial infarction (MI), is a major contributor toward the development of heart failure (HF), a progressive disease affecting millions of patients and costing billions of dollars annually. Myeloid cells are rapidly recruited to or activated within the heart following acute injury or stress where their regulation of cardiac function and remodeling are sensitive to β2-adrenergic receptor (β2AR) activity. The goal of this project is to define how myeloid cell-expressed β2AR regulates cardiac function and remodeling after injury and whether β2AR-selective therapeutics can regulate the myeloid cell-specific impact on injury.

PI_NAMEs: TILLEY, DOUGLAS  (contact)

PROJECT_TERMS: Acute;Adrenergic beta-Antagonists;Affect;angiogenesis;Angiogenic Factor;Annexin A1;Apoptotic;beta-2 Adrenergic Receptors;Biological Response Modifiers;Blood capillaries;Bone Marrow;Capillary Endothelial Cell;Cardiac;Cardiac Myocytes;cardiac repair;Cell Separation;Cells;Chronic;Clinical;comparative;cost;density;Development;Dose;Echocardiography;Exhibits;exosome;extracellular vesicles;Fibrosis;Gene Expression;Genes;Goals;Heart;Heart failure;heart function;Heart Injuries;heart preservation;Human;Immune;improved;In Vitro;Inflammatory;Injury;insight;Interleukins;ischemic injury;Leukocytes;Macrophage;Mediating;Mediator;Metoprolol;Molecular;monocyte;mouse model;Mus;Myeloid Cells;Myocardial Infarction;neutrophil;Outcome;paracrine;Pathway interactions;Patients;peripheral blood;Phagocytosis;Population Dynamics;Process;Progressive Disease;Property;Receptor Signaling;recruit;Regulation;repaired;response;Stress;Therapeutic;Time;Tissues;Tube;Vascular Endothelial Growth Factors;Wild Type Mouse

PROJECT_TITLE: Project 3


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: ATLANTA

PHR: NARRATIVE This T32 training program in the Environmental Health Sciences and Toxicology is designed to assure that trainees gain the skills they need to develop as successful independent, transdisciplinary, ethically engaged environmental health researchers and practitioners. It builds upon our unique focus on exposome research and affords trainees the opportunities to gain a holistic and rigorous knowledge-base, perform innovative research, and gain skills to excel in careers addressing significant public health challenges related to environmental exposures.

PI_NAMEs: MARSIT, CARMEN JOSEPH (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TITLE: Graduate and Postdoctoral Training in Environmental Health Science and Toxicology

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS (T)]


ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Narrative OVERALL; PD – Pascual, V. A major problem in the field of human autoimmunity is the diversity of clinical manifestations and pathways leading to disease. The ACE at Weill Cornell Medicine aims to 1) better understand pathways and mechanisms that contribute to development and amplification of Human Systemic Autoimmune Diseases, 2) develop tools and identify biomarkers to monitor these pathways in patients, and 3) share expertise with colleagues across all basic and clinical ACE Programs.The proposed Center will employ state-of-the-art technologies to gain insight into how two major and complementary compartments contribute to systemic disease: Immune cells and extra- cellular nanoparticles that can modulate the function of cells that uptake them.

PI_NAMEs: PASCUAL, MARIA VIRGINIA (contact)

PROJECT_TERMS: Adopted;Adult;Anti-DNA Antibodies;Autoimmune Diseases;Autoimmunity;autoinflammatory diseases;B cell differentiation;B cell therapy;B-Lymphocyte Subsets;B-Lymphocytes;Back;Basic Science;Behavior;bench to bedside;Bioinformatics;Biological;Biological Assay;Biological Markers;biomarker identification;Blood;Cancer Biology;CD3 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Compartmentation;Cell Physiology;Cells;Cellular biology;Child;Child Health;Childhood;Classification;Clinical;Clinical Trials;cohort;Collaborations;Color;Communicable Diseases;Communities;cytokine;Data;Dendritic Cells;Development;Diagnosis;Disease;disease heterogeneity;Disease remission;DNA;Effector Cell;Enzymes;Epigenetic Process;exosome;experience;extracellular;Feces;Flagellin;Flow Cytometry;Gene Expression Profile;Genetic Transcription;Goals;Hand;Heterogeneity;Histiocytosis haematophagic;Human;Hypersensitivity;Immune;Immunoglobulin-Secreting Cells;Immunology;In Vitro;in vitro Model;Infiltration;Inflammasome;Inflammatory;Infrastructure;insight;intercellular communication;Interleukin-2;International;Kidney;Knowledge;Ligation;Liquid substance;Lupus Nephritis;Malignant Neoplasms;Maps;Measurement;Measures;Medicine;microbiome;Molecular Biology;Monitor;monocyte;multidisciplinary;Mutation;nanoparticle;New York;particle;Pathologic;Pathway interactions;patient oriented;patient stratification;Patients;Permeability;personalized approach;personalized medicine;Phenotype;Physiological;Pilot Projects;Plasma;Plasma Cells;Process;Productivity;programs;Proteins;Proteomics;Recording of previous events;Regulatory T-Lymphocyte;relapse prediction;Research;Research Personnel;Research Project Grants;response;Secretory Immunoglobulin A;Sorting;standard of care;Structure;superresolution microscopy;Surface;Synovial Fluid;systemic autoimmune disease;systemic autoimmunity;Systemic disease;Systemic Lupus Erythematosus;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;technological innovation;Technology;Testing;tool;transcriptomics;Translational Research;treatment response;uptake;Urine;Work

PROJECT_TITLE: Immune Cells and Secretory Pathways Leading to Human Systemic Autoimmunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 JTS-I (J1)]


ORG_STATE: GA

PHR: Human autoimmune diseases comprise a large number of conditions including systemic diseases such as Lupus or Rheumatoid Arthritis and organ-specific diseases such as Type 1 Diabetes and Multiple Sclerosis. To understand this complexity, there is a need to continue the multidisciplinary work that has been fostered by the Autoimmunity Centers of Excellence Network over the last 25 years. The Emory Autoimmunity Center of Excellence will continue our work in Lupus while collaborating with other ACE Centers in the study of other autoimmune diseases.

PI_NAMEs: SANZ, IGNACIO E. (contact)

PROJECT_TERMS: Administrative Coordination;Antigens;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;B cell differentiation;B-Lymphocytes;biobank;Cell Physiology;Cells;Clinical;clinical development;Clinical Protocols;Clinical Research;Collaborations;Collection;CRISPR screen;Diagnosis;Disease;Epigenetic Process;epigenetic regulation;experience;Fostering;Funding;gain of function;Generations;Genes;Genetic Predisposition to Disease;Goals;Heterogeneity;Human;Immune;immunogenic;Immunoglobulin-Secreting Cells;Immunologics;Individual;innovation;Insulin-Dependent Diabetes Mellitus;Knowledge;Leadership;loss of function;Lupus;member;Memory;Memory B-Lymphocyte;Mission;Molecular;multidisciplinary;Multiple Sclerosis;novel;operation;Organ;Pathogenicity;Pathway interactions;Patients;Physicians;Pilot Projects;Play;Population;Process;programs;Regulation;Research;Resources;response;Rheumatoid Arthritis;Role;Sampling;Scientist;Structure of germinal center of lymph node;Systemic disease;Systemic Lupus Erythematosus;Technology;technology platform;Translating;Universities;Work

PROJECT_TITLE: Regulation of B cell Responses in SLE and Other Autoimmune Diseases


NIH_SPENDING_CATS: Autoimmune Disease;Lupus

PROJECT_TERMS: Address;Administrator;Agreement;Autoimmune Diseases;Autoimmunity;biobank;Cells;collaborative environment;Communication;Data;data sharing;Ensure;Fostering;Funding;Goals;Human;human subject;Immune;Infrastructure;Leadership;Lupus;Medicine;Monitor;multidisciplinary;National Institute of Allergy and Infectious Disease;Pathway interactions;Physicians;Pilot Projects;Productivity;programs;Progress Reports;Recommendation;Reporting;Research;Research Personnel;Resource Allocation;Resource Sharing;Resources;Sampling;Scientist;Site;systemic autoimmunity;United States National Institutes of Health;Virginia;Work


NIH_SPENDING_CATS: Autoimmune Disease;Lupus;Patient Safety

PHR: Project Narrative Not required for this component.

PROJECT_TERMS: Accounting;Accreditation;Animals;Autoimmune Diseases;Autoimmunity;Award;B-Lymphocytes;biobank;Budgets;Cataloging;Certification;Communication;Communities;Complex;Conflict of Interest;Credentialing;data sharing;Disclosure;Ensure;Expenditure;Funding;General Population;Goals;Grant;Guidelines;Human;Human Resources;Immunology;Information Dissemination;Institution;Investigation;Laboratory Personnel;Lead;Leadership;medical schools;meetings;Occupational activity of managing finances;Office Management;operation;patient safety;Policies;Productivity;Protocols documentation;Radiation;Regulation;Research Personnel;Research Subjects;Resources;response;Safety;Sampling;Structure;success;symposium;Systemic Lupus Erythematosus;Training;United States National Institutes of Health;Universities;Update;Visit


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research

PROJECT_TERMS: Acceleration;Applied Research;Autoimmune;Autoimmune Diseases;Autoimmunity;Bar Codes;biobank;Blood specimen;Cells;Clinical;clinical research site;Clinical Trials;Collaborations;Collection;Communication;Data;Data Management Resources;design;Diagnosis;Ensure;Equipment and supply inventories;fundamental research;Future;Goals;Human;Immune;Immunology;improved;Individual;Laboratories;Lead;Manuals;meetings;member;Mission;National Institute of Allergy and Infectious Disease;participant enrollment;Pathway interactions;Prevention;Procedures;Process;programs;Protocols documentation;Reporting;Research;Resolution;Resources;Retrieval;sample collection;Sampling;Scheme;Scientist;service coordination;Shipping;Site;Standardization;systemic autoimmunity;time interval;tool;Training;Work

PROJECT_TITLE: Biorepository Core


PROJECT_TERMS: Accountability;Active Sites;Agreement;Autoimmune Diseases;B-Lymphocytes;Budgets;Clinical;Clinical Management;Communication;Development;Direct Costs;Funding;member;National Institute of Allergy and Infectious Disease;Procedures;Regulation;Reporting;Research;response;Services;Site;Systemic Lupus Erythematosus;Universities


PROJECT_TITLE: Funds Mgmt Core


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Immunotherapy;Lupus;Pediatric;Precision Medicine

PROJECT_TERMS: Adult;Affect;Antigen-Antibody Complex;Autoimmune Diseases;Autoimmunity;B cell differentiation;B cell therapy;B-Lymphocytes;Behavior;Biological Markers;biomarker identification;Blood;BLR1 gene;CD4 Positive T Lymphocytes;Cell Compartmentation;Cells;Childhood;Classification;Clinical;Clinical Trials;Clinical Trials Design;cohort;Color;Cross-Sectional Studies;CXCL13 gene;CXCR3 gene;Dendritic Cells;Deposition;Diagnosis;Disease;disease heterogeneity;Effector Cell;Epigenetic Process;Erythroid Cells;Failure;Feces;Flagellin;Flow Cytometry;Frequencies;Genetic Transcription;Goals;Hand;Helper-Inducer T-Lymphocyte;Heterogeneity;Human;Immune;Immune system;improved;Individual;Infiltration;Inflammation;inflammatory milieu;Interferons;Interleukin-10;interleukin-21;Kidney;Knowledge;Ku70 protein;Lead;Ligation;Lupus Nephritis;Maps;Memory;memory CD4 T lymphocyte;microbiome;Mitochondrial DNA;Molecular;Monitor;Mucous Membrane;multiple omics;neutrophil;new therapeutic target;novel;Nucleic Acids;Orthologous Gene;Outcome;overexpression;Pathogenesis;Pathogenicity;Pathway interactions;Patient Selection;patient stratification;Patients;Peripheral;personalized care;Phenotype;polarized cell;Predisposition;Production;Proteomics;receptor;Regulatory Pathway;Regulatory T-Lymphocyte;Reporting;Resources;response;Secretory Immunoglobulin A;Series;single-cell RNA sequencing;Sorting;standard of care;stem;Stratification;Surface;systemic autoimmune disease;systemic autoimmunity;Systemic Lupus Erythematosus;T-Lymphocyte Subsets;targeted treatment;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;TLR5 gene;tool;transcriptomics;treatment response

PROJECT_TITLE: Principal Project


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Lupus;Precision Medicine

PI_NAMEs: LYDEN, DAVID CHARLES (contact)

PROJECT_TERMS: Acute;Affect;Anti-DNA Antibodies;Antibodies;Antigen-Presenting Cells;Antinuclear Antibodies;Autoimmune Diseases;Automobile Driving;B-Lymphocytes;Biological;Biological Markers;candidate marker;CD3 Antigens;CD8B1 gene;Cells;Cerebrospinal Fluid;Chronic;Classification;Clinical;Clinical Trials;clinically relevant;Collaborations;Complex;CXCL10 gene;CXCR3 gene;cytokine;cytotoxic;Deoxyribonucleases;design;Diagnosis;Disease;disease heterogeneity;Disease remission;Distant;DNA;ds-DNA;Enzymes;Equilibrium;exosome;Flare;genome sequencing;Heterogeneity;High Prevalence;Histones;Human;Immune;immunogenic;immunogenicity;In Vitro;in vitro Model;indexing;Individual;Inflammation;Inflammatory;Interferon Activation;Interferon Type II;Interferons;Interleukin-1 beta;Interleukin-2;Liquid substance;Longitudinal Studies;Lupus;Macrophage;Measurement;Measures;Molecular;Monitor;monocyte;Morbidity - disease rate;Mutation;Nephritis;novel;Nucleic Acids;Organ;Pathogenicity;Pathology;Pathway interactions;Patients;personalized medicine;Persons;Phenotype;Plasma;Plasma Cells;predictive marker;prevent;Process;Proteins;Proteomics;Relapse;relapse prediction;response;Role;Scleroderma;Skin;Source;Structure;Synovial Fluid;System;systemic autoimmune disease;systemic autoimmunity;Systemic disease;Systemic Lupus Erythematosus;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Time;treatment response;Urine;whole genome;Women's prevalence

PROJECT_TITLE: Collaborative  Project


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Immunotherapy;Lupus

PROJECT_TERMS: 2019-nCoV;Abnormal Cell;Acute;Affinity;age related;Antigens;Autoantibodies;Autoantigens;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;autoreactive B cell;autoreactivity;B-Lymphocytes;Black race;Blood;cancer immunotherapy;Cell Physiology;cell type;Cells;Chronic;cytokine;Derivation procedure;Disease;Distant;Effector Cell;Epigenetic Process;Exposure to;Flare;Flow Cytometry;Functional disorder;Generations;Genetic Predisposition to Disease;Genetic Transcription;Heterogeneity;HIV;Human;Hyperactivity;Immune response;Immune System Diseases;immunogenic;Immunoglobulin-Secreting Cells;imprint;Infectious Agent;insight;Interferon Type II;Interferons;interleukin-21;ITGAX gene;Kidney;Knowledge;Light;Lupus;lymph nodes;Measures;Memory;Memory B-Lymphocyte;microbiome;Molecular;molecular diagnostics;multiple omics;Pathogenesis;pathogenic autoantibodies;Pathogenicity;Pathway interactions;Patients;Phenotype;Pilot Projects;Population;Precision therapeutics;Process;programs;Property;Protocols documentation;Reaction;Regulation;Reporting;Research Personnel;response;SARS-CoV-2 infection;segregation;severe COVID-19;Stimulus;Structure of germinal center of lymph node;systemic autoimmune disease;Systemic Lupus Erythematosus;Tissues;TLR7 gene;treatment response;Vaccination


NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Lupus

PI_NAMEs: SCHARER, CHRISTOPHER D (contact)

PROJECT_TERMS: Antibodies;Antigens;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;autoreactive B cell;autoreactivity;B cell differentiation;B-Cell Antigen Receptor;B-Lymphocyte Differentiation Antigens;B-Lymphocyte Subsets;B-Lymphocytes;Biological Assay;Black race;BLR1 gene;Cell Compartmentation;Cell Lineage;cell type;Cells;Chinese population;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;cohort;Collaborations;Complementary DNA;CRISPR screen;CRISPR/Cas technology;Cues;Disease;Epigenetic Process;European;experimental study;Flare;Future;gain of function;Gene Expression;Gene Expression Profile;gene interaction;gene network;gene regulatory network;Generations;Genes;Genetic;Genetic Engineering;Genetic Predisposition to Disease;Genetic Risk;Genome engineering;Goals;Human;Immunoglobulin D;Immunoglobulin-Secreting Cells;insight;ITGAX gene;Japanese Population;Libraries;loss of function;Memory;Memory B-Lymphocyte;Molecular;molecular phenotype;novel;Outcome;overexpression;Pathogenesis;Pathogenicity;Pathway interactions;Phenotype;Pilot Projects;plasma cell differentiation;Plasma Cells;programs;Regulation;response;Rest;risk variant;Role;SARS-CoV-2 infection;severe COVID-19;Signal Transduction;synergism;System;systemic autoimmune disease;Systemic Lupus Erythematosus;Techniques;Testing;TLR7 gene;transcription factor;Untranslated RNA


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Infectious Diseases;Lupus;Neurodegenerative;Orphan Drug;Precision Medicine;Rare Diseases;Rural Health

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

PHR: Project Narrative Autoimmune diseases afflict up to 12% of the US population and remain a common cause of morbidity and early mortality. Non-toxic, effective therapeutics often do not exist. This program focuses on identifying molecular homogeneous subsets of patients to aid trials, inform treatment and improve patient outcomes.

PI_NAMEs: JAMES, JUDITH A (contact)

PROJECT_TERMS: acute care;Address;Affect;Aliquot;antagonist;ATAC-seq;Autoantibodies;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;Autoimmune Process;Autoimmunity;B-Cell Activation;B-Lymphocytes;base;belimumab;biobank;Biology;biomarker selection;Cell Lineage;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Certification;Chronic;Clinic;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;Collaborations;Complex;Data;Dedications;design;Development;disability;Disease;disease heterogeneity;Double-Blind Method;Education;effectiveness evaluation;effectiveness testing;efficacy testing;Epigenetic Process;experience;Flare;Fortification;Foundations;Funding;Genes;Genetic;Genetic Diseases;Genomics;Goals;Heterogeneity;Human Herpesvirus 4;Human Resources;Immune;Immunologist;Immunology;Immunomodulators;immunomodulatory therapies;immunopathology;Immunophenotyping;Immunosuppressive Agents;improved;Individual;Inflammatory;innovation;intercalation;Interdisciplinary Study;Interferon Activation;Interferon Type I;Interferons;latent virus activation;Lead;Lupus;Machine Learning;Manuscripts;Mediator;Methods;methylation pattern;mimicry;minority communities;Molecular;Molecular Disease;Molecular Profiling;monocyte;Morbidity - disease rate;mortality;multidisciplinary;multiple omics;Neuromyelitis Optica;Oklahoma;Pathogenesis;Pathogenicity;Pathway interactions;Patient Outcomes Assessments;patient subsets;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Placebo Control;Policies;Population;pre-clinical;predictive marker;Procedures;Production;profiles in patients;programs;Protocols documentation;reactivation from latency;recruit;Relapse;relapse risk;Research;Research Infrastructure;Research Personnel;responders and non-responders;response;Role;Rural Community;Safety;sample collection;Scholars Program;Science;Scientific Advances and Accomplishments;Scientist;Selection for Treatments;single cell technology;single-cell RNA sequencing;Site;Sjogren's Syndrome;standard of care;Steroids;success;synergism;System;Systemic Lupus Erythematosus;targeted treatment;Testing;therapeutically effective;transcriptomics;translational scientist;treatment response;trial design;type I interferon receptor;Urban Community;Vaccination;Viral;Virus Diseases;Visit;Withdrawal;Work

PROJECT_TITLE: Oklahoma ACE: Molecular Destruction of Autoimmune Disease to Aid Clinical Trail Success


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE - OVERALL The mission of the University of Chicago Medicine Comprehensive Cancer Center (UCCCC) is to eradicate cancer through equitable prevention, innovative and collaborative research, compassionate patient care, inclusive education and dedicated community engagement.

PI_NAMEs: ODUNSI, KUNLE  (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Back;Calendar;Cancer Burden;cancer care;Cancer Center Support Grant;Cancer Control;cancer education;cancer health disparity;cancer prevention;Cancer Science;career;Catchment Area;Chicago;Climate;Clinic;Clinical;Clinical Data;clinical investigation;Clinical Protocols;Clinical Trials;Collaborations;Communication;Communities;community collaboration;community engagement;Community Outreach;community research;Comprehensive Cancer Center;County;data management;Dedications;design;Disclosure;Disease;Doctor of Philosophy;drug development;drug discovery;Education;Equity;equity, diversity, and inclusion;Ethnic Origin;Funding;Grant;Guidelines;health equity;Immunology;improved;Infrastructure;innovation;Institution;Intervention;Intervention Trial;invention;Investigational Therapies;investigator-initiated trial;Investments;Journals;Laboratories;Leadership;Legal patent;Malignant Neoplasms;Medicine;member;Mentorship;Minority;Mission;Molecular;Monitor;multidisciplinary;National Comprehensive Cancer Network;next generation;novel therapeutic intervention;novel therapeutics;Oncology;Outcome;outreach;Paper;Participant;Patient Care;Patients;Pediatric Oncology Group;Peer Review;Population;population based;Population Sciences;Positioning Attribute;Preclinical Testing;Prevention;programs;Protocols documentation;Publications;Publishing;Quality of life;Recording of previous events;recruit;Research;Research Personnel;Resource Sharing;Science;Scientist;Secure;Strategic Planning;Survivors;System;Talents;Technology;Textiles;Therapeutic;Training;Training and Education;Translating;Translational Research;Translations;Underserved Population;Universities;Validation;Vision;Workforce Development

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: MEMMOTT, DREW  (contact)

PROJECT_TERMS: Access to Information;Administrative Supplement;Advisory Committees;Advocacy;anti-cancer research;Award;Basic Science;Biological Sciences;Budgets;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer health equity;Catchment Area;Chicago;Clinical Data;clinical investigation;Clinical Protocols;Clinical Sciences;Clinical Trials;Collaborations;Communication;Communities;community engaged research;community engagement;Community Outreach;Comprehensive Cancer Center;Contracts;Core Facility;Data;Data Analytics;data management;Databases;Dependence;Development;Education;Ensure;equity, diversity, and inclusion;Evaluation;Event;Faculty;Faculty Recruitment;Fostering;Funding;Funding Opportunities;Goals;Grant;Guidelines;Human Resources;improved;Informatics;Infrastructure;Intervention;Investments;Laboratories;Leadership;Maintenance;Malignant Neoplasms;Manuals;Medicine;meetings;member;metabolomics;Mission;Monitor;new technology;news;Occupational activity of managing finances;Organoids;parent project;Peer Review;Performance;Pilot Projects;Policies;Population Sciences;Process;programs;Protocols documentation;Publications;recruit;Regulation;Reporting;Research;Research Personnel;Resource Sharing;Resources;Safety;satisfaction;Science;service member;Services;Site;Societies;Source;Strategic Planning;Structure;success;Surveys;symposium;System;Therapeutic;Time;Training and Education;Universities;University adminstration;Vision;Work;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Pediatric

PI_NAMEs: ARMATO, SAMUEL G. (contact)

PROJECT_TERMS: aging related;anti-cancer research;Assistantship;Award;Cancer Center Support Grant;cancer health disparity;Cancer health equity;career;career development;Career Exploration;career networking;Caring;Catchment Area;Categories;Chicago;Clinical;Collaborations;Communication;Communities;community engagement;community organizations;Community Outreach;Complement;Comprehensive Cancer Center;Dedications;Development;Doctor of Philosophy;doctoral student;Education;Educational Curriculum;Educational workshop;empowerment;experience;Faculty;Fellowship;Fellowship Program;Funding;Funding Opportunities;Goals;graduate student;Grant;Health;high school;high school program;High School Student;Individual;Infrastructure;innovation;Institution;interest;Investments;Leadership;Learning;Malignant Neoplasms;Medical;medical schools;Medical Students;Medicine;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Mission;multidisciplinary;Oncology;Oranges;Pathway interactions;peer;peer coaching;Physicians;Play;Postdoctoral Fellow;Prevention;Productivity;programs;Research;Research Personnel;Research Support;Research Training;Residencies;Resource Development;Resources;Role;Schools;Science;Scientist;senior faculty;Series;Services;Side;skill acquisition;skills;Strategic Planning;Students;success;support network;symposium;System;TNFSF15 gene;Training;Training and Education;training opportunity;Training Programs;Travel;undergraduate student;Underrepresented Populations;Universities;university student;Writing;Youth

PROJECT_TITLE: Cancer Research Training and Education Coordination


PI_NAMEs: ROMERO, IRIS L (contact)

PROJECT_TERMS: Academia;Acceleration;Accountability;Address;American;anti-cancer research;Basic Science;Biomedical Research;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer therapy;career development;Career Mobility;Catchment Area;Characteristics;Chicago;Climate;Clinical Research;Clinical Sciences;cohort;Collaborations;Communities;community building;community center;community engagement;Community Networks;Community Outreach;Comprehensive Cancer Center;Dedications;demographics;diversity and inclusion;Educational Curriculum;Environment;equity, diversity, and inclusion;Evaluation;Faculty;Female;Fostering;Goals;Health;higher education;Human Resources;Individual;Infrastructure;Institution;Investments;Leadership;Link;Logic;Malignant Neoplasms;Measures;medical schools;Medicine;member;Mentors;Mentorship;Modeling;Monitor;Outcome;Pathway interactions;Persons;Policies;Population;Population Research;Positioning Attribute;Postdoctoral Fellow;Process;programs;Race;recruit;Research;Research Activity;Research Personnel;Resources;Scholars Program;Science;Strategic Planning;Student recruitment;Students;success;Training;Training and Education;Translational Research;Underrepresented Minority;Underrepresented Populations;Universities;Woman;Work

PROJECT_TITLE: Plan to Enhance Diversity


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Precision Medicine;Prevention

PI_NAMEs: STOCK, WENDY  (contact)

PROJECT_TERMS: Acceleration;Address;anti-cancer;anti-cancer research;arm;Award;Basic Science;bench to bedside;Biological Markers;Cancer Burden;cancer care;Cancer Center Support Grant;cancer health disparity;cancer imaging;cancer therapy;career development;Catchment Area;cellular engineering;Chicago;Childhood Solid Neoplasm;Clinical;clinical care;Clinical Drug Development;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;community engagement;Community Outreach;community partners;Comprehensive Cancer Center;design;Devices;Disparity population;Diverse Workforce;Doctor of Philosophy;Dose;drug development;Drug resistance;Drug Utilization;Education;epigenomics;epitranscriptomics;experience;Fostering;Funding;Genitourinary system;Goals;Grant;Hematologic Neoplasms;imaging approach;imaging biomarker;Immune Targeting;Immunotherapy;Individual;Industry;industry partner;innovation;insight;Intervention Trial;Investigation;Investigational Drugs;Investigational Therapies;investigator-initiated trial;Journals;Laboratories;Leadership;Malignant Neoplasms;Medical Oncologist;Medicine;meetings;member;Mentors;Mission;Molecular Target;mortality;Multi-Institutional Clinical Trial;NCI Center for Cancer Research;new therapeutic target;next generation;novel;Patients;Pediatric Oncologist;Peer Review;Phase;pre-clinical;precision medicine;precision oncology;Precision therapeutics;predictive marker;Prevalence;Prognostic Marker;programs;Publications;Reporting;Research;Research Personnel;Resistance;resistance mechanism;response;Role;Safety;Science;Scientist;Strategic Planning;Structure;targeted treatment;Testing;theranostics;Therapeutic;therapeutic biomarker;Therapeutic Clinical Trial;therapeutic development;Therapeutic Trials;therapy resistant;Training;Training and Education;translational framework;Translational Research;translational scientist;Treatment Efficacy;Treatment-related toxicity;trial design;tumor;tumor immunology;tumor metabolism;Universities;Validation;Work;working group

PROJECT_TITLE: Clinical and Experimental Therapeutics


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Precision Medicine;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health;Women's Health Research

PI_NAMEs: PIERCE, BRANDON LEE (contact)

PROJECT_TERMS: Address;Advocate;Affect;African ancestry;Alcoholic beverage heavy drinker;Area;Arsenic;Behavior;Black Populations;Breast Cancer Risk Factor;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Detection;Cancer Etiology;cancer health disparity;cancer imaging;cancer prevention;cancer risk;cancer subtypes;Cancer Survivor;Carcinogenesis Mechanism;Case/Control Studies;Catchment Area;cellular engineering;Chemical Exposure;Chicago;childhood cancer survivor;Clinical;clinical care;clinical practice;Clinical Research;Clinical Trials;cohort;Collaborations;Communities;community setting;Comprehensive Cancer Center;Data Commons;Data Sources;Detection;Discipline;disparity reduction;Ensure;Epigenetic Process;epigenomics;epitranscriptomics;equity, diversity, and inclusion;Faculty;Faculty Recruitment;Fostering;Friends;Funding;Future;Genes;Genetic;Genetic Risk;Goals;Health;health care settings;health communication;Health Policy;health related quality of life;Hepatitis C;Hispanic Populations;imaging approach;imaging modality;Immunotherapy;improved;improved outcome;Infrastructure;innovation;Interdisciplinary Study;International;Intervention;Investments;Journals;Knowledge;Lesbian Gay Bisexual Transgender Queer;Life Style;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;Medicine;member;Mentorship;Mission;Modeling;NCI Center for Cancer Research;next generation;novel;Obesity;Patients;Pharmaceutical Preparations;Pilot Projects;polygenic risk score;Population;Population Sciences;precision medicine;precision oncology;Predisposition;prevent;Prevention;Primary Prevention;Productivity;programs;Public Health Practice;Publications;recruit;Research;Research Infrastructure;Research Priority;Resource Sharing;Resources;Risk Factors;Scientist;screening;Screening for cancer;screening guidelines;Seminal;Shapes;Smoker;social structure;sociodemographics;socioeconomics;Strategic Planning;structural determinants;survivorship;synergism;Technology;Testing;Therapeutic;tobacco cessation intervention;Training;Translating;tumor immunology;tumor metabolism;United States National Institutes of Health;Universities;Woman;Work;working group

PROJECT_TITLE: Cancer Prevention and Control


PI_NAMEs: GAJEWSKI, THOMAS F (contact)

PROJECT_TERMS: Address;Adjuvant;Antibodies;Antigen Presentation;Antigen Targeting;Back;Basic Science;biobank;Cancer Burden;Cancer Center Support Grant;cancer health disparity;cancer imaging;Cancer Model;cancer type;Cancer Vaccines;Carcinogens;Cell Therapy;cellular engineering;Chicago;chimeric antigen receptor T cells;Clinic;Clinical;clinical application;clinical development;Clinical Trials;Collaborations;Communities;Community Health Education;Comprehensive Cancer Center;Core Facility;Cyclic GMP;Development;Disease;Education;engineered T cells;Engineering;Environment;epigenomics;epitranscriptomics;Faculty;Faculty Recruitment;Fostering;fundamental research;Funding;Genetic Engineering;Goals;Heterogeneity;Home;Human;imaging approach;immune checkpoint blockade;Immune response;Immune system;Immunologics;Immunologist;Immunology;immunoregulation;Immunotherapeutic agent;Immunotherapy;immunotherapy clinical trials;in vivo;industry partner;Infrastructure;innovation;insight;Integration Host Factors;Intervention;Investigational Therapies;Investments;Knowledge;Laboratories;Malignant Neoplasms;Medicine;member;Mentors;microbiota;mouse model;Myeloproliferative disease;Nature;neoplasm immunotherapy;novel;novel strategies;novel therapeutic intervention;Patients;Play;pre-clinical;Pre-Clinical Model;precision medicine;precision oncology;Production;programs;Property;recruit;Regulatory Pathway;Research;Research Personnel;Role;Science;Scientist;Solid Neoplasm;Source;Strategic Planning;symposium;T cell response;T cell therapy;T-Lymphocyte;Technology;Testing;Therapeutic;Toxic effect;Translating;Transplantation;treatment strategy;tumor;Tumor Antigens;Tumor Immunity;tumor immunology;tumor metabolism;tumor microenvironment;Universities;vector

PROJECT_TITLE: Immunology and Cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine

PI_NAMEs: KEE, BARBARA L. (contact)

PROJECT_TERMS: Acceleration;Affect;anti-cancer research;Award;Basic Cancer Research;Basic Science;Behavior;cancer biomarkers;Cancer Burden;Cancer Cell Growth;Cancer Center Support Grant;cancer health disparity;cancer imaging;cancer initiation;cancer prevention;Cancer Research Project;cancer stem cell;Catchment Area;Cell Communication;Cell Death;cell growth;cell transformation;Cells;cellular engineering;Chicago;chromatin modification;clinical application;Clinical Cancer Center;Clinical Trials;Collaborations;commercialization;Communities;Comprehensive Cancer Center;Death Rate;Defect;Detection;Development;Diagnosis;Discipline;DNA;DNA Sequence Rearrangement;Drug Delivery Systems;Drug resistance;Education and Outreach;Ensure;Environment;Epigenetic Process;epigenomics;epitranscriptomics;equity, diversity, and inclusion;Evolution;Faculty;Faculty Recruitment;Fostering;Funding;Future;gender diversity;Gene Expression;genetic signature;Goals;Health Benefit;Histones;imaging approach;Immunotherapy;Incidence;Infrastructure;innovation;Institution;intercellular communication;Investigational Therapies;Laboratories;Leadership;Malignant Neoplasms;Medicine;meetings;member;Metabolic;Mission;Modification;Molecular;multidisciplinary;nanoengineering;Nature;Neoplasm Metastasis;neoplastic cell;next generation;novel;Organ;outcome disparities;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Persons;physiologic stressor;Pilot Projects;Play;precision medicine;precision oncology;Productivity;programs;Proliferating;Publications;racial diversity;recruit;Research;Research Personnel;Research Training;response;RNA;Role;Science;Scientist;Site;skin patch;stem cell expansion;Strategic Planning;Stromal Cells;success;synergism;Talents;targeted cancer therapy;Technology;Therapeutic;Therapeutic Intervention;Training and Education;translational approach;translational goal;translational scientist;Translations;tumor;tumor growth;tumor immunology;tumor metabolism;tumor microenvironment;tumor progression;Underrepresented Minority;Universities;Woman;Work;working group

PROJECT_TITLE: Molecular Mechanisms of Cancer


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: KIM, KAREN E (contact)

PROJECT_TERMS: Address;Advocate;Air;American Society of Clinical Oncology;anti-cancer research;Area;Asian;Basic Science;bilingualism;Black race;Breast;Cancer Advocacy;Cancer Burden;cancer care;Cancer Center Support Grant;Cancer Control;cancer education;Cancer health equity;Cancer Patient;cancer prevention;cancer therapy;care delivery;Caring;Catchment Area;Cervix Uteri;Chemical Exposure;Chicago;Cities;Climate;Clinical Sciences;Clinical Trials;Collaborations;Colorectal;Communities;community advisory board;community collaboration;community engagement;community engagement process;Community Health Aides;Community Outreach;community partners;community research;Comprehensive Cancer Center;Continuity of Patient Care;cooking;County;COVID-19 pandemic;Data;Data Analyses;data infrastructure;data visualization;digital;Disparity;Education;Educational Activities;Enrollment;Environmental Exposure;Environmental Risk Factor;Equity;Ethnic Population;Faculty;Fostering;Funding;Future;Geographic Information Systems;Geographic Locations;Grant;Health Services Accessibility;Health system;Hispanic;hispanic community;Human Papilloma Virus Vaccination;Improve Access;improved;Incidence;Indiana;Individual;Information Dissemination;Infrastructure;innovation;Intervention;Investments;Lead;Leadership;Link;literacy;Liver;Lung;Malignant Neoplasms;Mediating;Medicaid;Medical center;Medicine;member;Minority Groups;Mission;modifiable risk;Monitor;mortality;Neighborhoods;Not Hispanic or Latino;Obesity;Online Systems;Oropharyngeal;Outcome Measure;outreach;Patients;Policies;Population;Population Growth;population health;Population Sciences;Poverty;Process Measure;programs;Prostate;Public Health;racial population;Research;Research Personnel;Research Priority;Resources;Risk Behaviors;Role;Science;screening;Screening for cancer;Services;skills training;social deprivation;social health determinants;Spanish;Statutes and Laws;Strategic Planning;Supportive care;survivorship;telehealth;Testing;tobacco control;Tobacco use;Training and Education;Translational Research;treatment trial;trend;Tumor Markers;Underrepresented Minority;Universities;Urban Health;Viral;Vision;Vulnerable Populations

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: SZMULEWITZ, RUSSELL Z (contact)

PROJECT_TERMS: Area;Awareness;Budgets;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Patient;Catchment Area;Chicago;Child;Clinical Data;Clinical Protocols;Clinical Research;Clinical Trials;Clinical Trials Network;clinically relevant;community engagement;Community Outreach;Comprehensive Cancer Center;data management;design;Development;Education;Ensure;Equity;equity, diversity, and inclusion;Ethics;Funding;Goals;Growth;improved;Industry;Informatics;Infrastructure;innovation;Institution;Intervention;Investigational Therapies;investigator-initiated trial;life span;Malignant Neoplasms;Medicine;Minority;National Clinical Trials Network;novel;Occupational activity of managing finances;Pathway interactions;Patients;programs;Protocols documentation;quality assurance;Quality Control;recruit;Reporting;Research Personnel;Resources;Talents;timeline;Training;Training and Education;Universities;Woman;Writing

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Precision Medicine;Prevention

PROJECT_TERMS: Acceleration;Address;animal imaging;Antibodies;Area;Artificial Intelligence;Award;base;Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;cancer imaging;cancer prevention;Catchment Area;Cell Therapy;cellular engineering;Chemistry;Chicago;Childhood;Clinical;Clinical Trials;cohort;Collaborations;Comprehensive Cancer Center;CRISPR/Cas technology;Cytometry;Development;Doctor of Philosophy;drug development;early phase clinical trial;Environment;Epidemiologist;epigenomics;epitranscriptomics;Equity;equity, diversity, and inclusion;Expenditure;Faculty Recruitment;flexibility;Funding;Funding Agency;Future;Goals;Grant;Growth;Health;health communication;Human;Image;imaging approach;imaging program;immunoengineering;Immunotherapy;implementation science;innovation;Institution;Interdisciplinary Study;Intervention;Investigation;Investigational Therapies;Investments;Journals;Laboratories;Leadership;lens;Machine Learning;Malignant neoplasm of prostate;Malignant Neoplasms;Medicine;Mission;Molecular;NCI Center for Cancer Research;Neuroblastoma;new technology;next generation;novel;Oncology;oncology trial;Organoids;outreach;peer;Peer Review;Peer Review Grants;Pharmaceutical Chemistry;Physicians;Pilot Projects;precision medicine;precision oncology;Primary Cell Cultures;Program Development;programs;Publications;racial minority;Radiochemistry;recruit;Research;Research Personnel;Research Priority;Resource Sharing;Resources;Science;Scientist;Services;Strategic Planning;success;synthetic biology;Technology;Therapeutic;Training and Education;Transgenic Mouse Facility;translational physician;tumor immunology;tumor metabolism;Universities;Woman

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Cancer;Prevention

PROJECT_TERMS: Address;Advisory Committees;Area;Basic Science;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;cancer prevention;Chicago;Clinical;clinical infrastructure;clinical investigation;Clinical Research;Clinical Sciences;Clinical Trials;Communication;Communities;community advisory board;community engagement;Community Outreach;Comprehensive Cancer Center;Decision Making;Department chair;Development;Doctor of Philosophy;Educational workshop;empowerment;Ensure;equity, diversity, and inclusion;Evaluation;experience;Family;Feedback;Funding;Funding Opportunities;Future;Goals;Group Meetings;implementation evaluation;improved;Institution;Interdisciplinary Study;Iris;Joints;Laboratories;Leadership;Malignant Neoplasms;Medicine;meetings;member;Mission;operation;Patients;Performance;Physicians;Policies;Population;Population Sciences;Positioning Attribute;Prevention;Process;programs;Publications;recruit;Research;Research Project Grants;Resource Development;Resource Sharing;Science;Scientist;Services;Shapes;Strategic Planning;Structure;success;synergism;Training and Education;Translational Research;Universities;Vision;Work;working group

PROJECT_TITLE: Leadership, Planning and Evaluation


PI_NAMEs: KINDLER, HEDY L (contact)

PROJECT_TERMS: Advisory Committees;Amendment;authority;Cancer Center Support Grant;cancer clinical trial;cancer research center director;Catchment Area;Chicago;Clinical Cancer Center;clinical investigation;Clinical Protocols;Clinical Research;Clinical Trials;Collection;Committee Membership;Communication;Comprehensive Cancer Center;Conduct Clinical Trials;Development;Disease;Enrollment;Ensure;Ethics;expectation;Fostering;Goals;Grant;Ice;improved;informatics infrastructure;Institution;life span;Malignant Neoplasms;Medicine;member;molecular phenotype;Monitor;multidisciplinary;Names;operation;organizational structure;Participant;Policies;Population;Procedures;Process;Protocols documentation;rare cancer;Reporting;Research;response;Review Committee;Role;Safety;Serious Adverse Event;Statistical Data Interpretation;statistics;Structure;System;Technology;Time;Training;Translational Research;trial design;Underrepresented Minority;Universities;Update

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: HE, YU-YING  (contact)

PROJECT_TERMS: Acceleration;Address;animal imaging;Antibodies;Appointment;Bioinformatics;Biological Sciences;Biometry;Budgets;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer health disparity;cancer imaging;cellular engineering;Charge;Chicago;Clinical Trials;Collaborations;Contracts;cost;cost effective;Cyclic GMP;Cytometry;Data;Development;Doctor of Philosophy;Education;Ensure;epigenomics;epitranscriptomics;Equipment;Evaluation;Event;Faculty;Fostering;Funding;Funding Mechanisms;Genomics;Goals;Grant;Human;human tissue;imaging approach;Immunologic Monitoring;Immunotherapy;Individual;innovation;Institution;interest;Laboratories;Leadership;Malignant Neoplasms;Marketing;member;metabolomics;Microscopy;Mission;new technology;novel;Organoids;Philanthropic Fund;Play;precision medicine;precision oncology;Primary Cell Cultures;Process;Productivity;programs;Proteomics;Qualifying;recruit;Research;research facility;research study;Research Support;Resource Sharing;Resources;Review Committee;Role;Science;screening;Services;Source;Strategic Planning;Surveys;Technology;Therapeutic;tissue resource;Tissues;Training;Transgenic Mouse Facility;tumor immunology;tumor metabolism;Universities

PROJECT_TITLE: Shared Resource Management


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine

PI_NAMEs: CHEN, MENGJIE  (contact)

PROJECT_TERMS: Acceleration;anti-cancer research;ATAC-seq;Basic Science;Bioinformatics;bioinformatics tool;Biological Assay;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer genomics;cancer health disparity;cancer imaging;cancer therapy;Cells;cellular engineering;Chicago;ChIP-seq;Client;Clinical Sciences;Clinical Trials;Code;Collaborations;Communities;Comprehensive Cancer Center;Computer software;Core Facility;Cost Analysis;Cytometry;dashboard;Data;data acquisition;Data Analyses;Data Collection;data management;Data Management Resources;Data Science;Dedications;design;Detection;Development;DNA Methylation;Documentation;Education;Emerging Technologies;Ensure;epigenomics;epitranscriptomics;exome sequencing;Experimental Designs;Fostering;Funding;Future;genome sequencing;genomic data;Genomics;Genotype;Grant;high standard;imaging approach;Immunotherapy;Information Management;innovation;Joints;Journals;Laboratories;Malignant Neoplasms;Medicine;meetings;member;Methodology;Monitor;multiple omics;novel;Peer Review;Pilot Projects;Population Sciences;portability;Positioning Attribute;precision medicine;precision oncology;Process;Production;programs;Proteomics;Publications;Reporting;Reproducibility;Research;Research Personnel;Resolution;Sampling;Scientist;Services;single-cell RNA sequencing;Somatic Mutation;Standardization;Strategic Planning;success;System;Testing;Therapeutic;Time;tool;Training;transcriptome sequencing;transcriptomics;Translating;Translational Research;tumor immunology;tumor metabolism;Universities;Vision;whole genome;Writing

PROJECT_TITLE: Bioinformatics Core Facility