ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Immunization;Infectious Diseases;Pediatric;Precision Medicine;Prevention;Sepsis;Vaccine Related

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Staphylococcus aureus is a leading cause of human infection. In spite of many years of research on this pathogen, we have limited knowledge of host genetic factors that govern susceptibility to infection. The focus of this proposal is to evaluate a human genetic polymorphism that may shed light on risk for S. aureus infection. The successful identification of an informative polymorphism will engender novel opportunities to develop a bedside-accessible, patient-specific genetic marker that can inform the approach to clinical care.

PI_NAMEs: BUBECK WARDENBURG, JULIANE  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Adult;alpha Toxin;Antibody titer measurement;Antimicrobial Resistance;Bacteremia;Binding;Binding Sites;Biological;Biological Markers;Biological Models;Bypass;Caring;cell injury;cell type;Cells;Cessation of life;Child;Childhood;Clinical;clinical care;Clinical Medicine;clinical practice;Clinical Research;Clinical Trials;Communicable Diseases;comparative;Complex;Cytotoxin;Data;Development;Disease;Disease susceptibility;Disintegrins;disorder risk;Economics;Engineering;Exhibits;Financial Hardship;Generations;Genetic;genetic epidemiology;Genetic Markers;Genetic Polymorphism;Genetic Predisposition to Disease;Genetic Variation;Genomic DNA;Genotype;Genus staphylococcus;Goals;Healthcare;Hemolysin;Hospitalization;Human;Human Genetics;Immunity;Individual;individual patient;Infection;infection risk;Infectious Skin Diseases;Injury;insight;Intervention;Knowledge;Mediating;Membrane;Metalloproteases;microbiome;Modification;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;Mus;Nature;novel;Odds Ratio;Outcome;pathogen;Pathogenesis;Patient risk;Patients;pediatric patients;personalized care;personalized medicine;Pneumonia;Population;precision medicine;Predisposition;prevent;progression risk;promoter;Proteins;Proteolysis;receptor;Recurrence;recurrent infection;Research;resistant strain;response;Retrospective Studies;Risk;risk prediction;risk stratification;Role;Sepsis;Septic Shock;Shapes;Single Nucleotide Polymorphism;Skin;Skin Tissue;soft tissue;Soft Tissue Infections;Staphylococcus aureus;Staphylococcus aureus infection;Surface;Therapeutic;tissue injury;Tissues;tool;Toxin;transcription factor;Translations;trend;United States;vaccine candidate;Vaccine Design;vaccine development;Vaccines;Variant;Virulence Factors

PROJECT_TITLE: ADAM10 polymorphism in susceptibility to S. aureus disease

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Methamphetamine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Methamphetamine use is an emerging threat to the health and well-being of Black gay, bisexual and other men who have sex with men (GBMSM). The proposed project will examine pathways between four forms of structural racism and discrimination (housing discrimination, gentrification, racial and income segregation, and discriminatory community climate for lesbian, gay, bisexual and transgender individuals) and methamphetamine use in this population. This information will be used to inform structural interventions to prevent methamphetamine use and related harms among Black GBMSM.

PI_NAMEs: HUSSEN, SOPHIA A. (contact);LINTON, SABRIYA L

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: behavior change;Bisexual;Black American;Black Populations;Black race;Censuses;Climate;cohort;Communities;community engaged research;community organizations;comorbidity;Data;design;Destinations;Development;Discrimination;Disparity population;dynamic system;Ecological momentary assessment;Economics;Educational workshop;Environment;Epidemic;Ethnography;examination questions;experience;Exposure to;follow-up;Foundations;Freedom;Gays;General Population;Goals;Harm Reduction;Health;health inequalities;Health Services Accessibility;Healthcare;Homelessness;homonegativity;Housing;housing instability;improved;Income;Individual;innovation;insight;Intervention;Interview;Knowledge;Lead;Lesbian Gay Bisexual Transgender;Link;Location;Longitudinal cohort study;Maps;Measures;Mediating;Mediator;men;men who have sex with men;Mental Health;Methamphetamine;Methamphetamine prevention;methamphetamine use;Methamphetamine use disorder;Methods;model building;outcome disparities;Participant;Pathway interactions;Personal Satisfaction;Persons;Pharmaceutical Preparations;Population;prevent;Prevention;prospective;Public Health;Race;recruit;Reporting;Research;residential segregation;response;Risk;Science;segregation;service providers;Services;social;Social status;social vulnerability;Social Work;Structural Racism;substance use treatment;Surveys;System;Technology Assessment;United States;United States National Institutes of Health;Walking;Work

PROJECT_TITLE: Structural Influences on Methamphetamine Use among Black Gay and Bisexual Men in Atlanta


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation;Wound Healing and Care

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE Oral wound healing is an ideal model for scarless tissue regeneration. Our proposal will test the hypothesis that Prx1+ oral fibroblasts are responsible for accelerating the healing process by functioning as stem cells that regulate immune response. Upon successful completion, our work may have a direct impact in the clinical utilization of connective tissues or ex vivo stem cell therapy using Prx1+ cells to treat a wide variety of human diseases.

PI_NAMEs: KO, KANG I (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Ablation;Acceleration;Anti-Inflammatory Agents;Area;Autologous Transplantation;Biological Assay;Biology;Cell Communication;Cell division;Cells;Chronic;chronic wound;Cicatrix;Clinical;Coculture Techniques;Connective Tissue;cranium;cytokine;Data;Dermis;Development;Diphtheria;Disease;Economic Burden;Exhibits;Failure;Fibroblasts;Functional disorder;gain of function;Genetic;Gingiva;Goals;healing;Heterogeneity;Histologic;Human;human disease;Immune;Immune response;immunoregulation;Impaired wound healing;improved;In Situ;In Vitro;in vivo;Inflammation;Inflammatory;insight;interest;joint inflammation;Joints;Knowledge;Leukocytes;Link;loss of function;Mediating;Mesenchymal;Mesenchymal Stem Cells;Messenger RNA;Modeling;Molecular;Mouth Diseases;Mus;Natural regeneration;Nature;novel;Oral;Oral cavity;oral fibroblast;Outcome;Pathogenesis;Pathology;Pathway interactions;Periodontal Diseases;Play;polarized cell;Population;postnatal;Process;progenitor;Proliferating;Property;Proteins;public health relevance;Resolution;response;Rheumatoid Arthritis;Role;segregation;single cell sequencing;single-cell RNA sequencing;Site;Skin;skin fibrosis;Source;stem cell therapy;stem cells;stemness;Synovial Membrane;System;Testing;tissue regeneration;Tissues;tool;transcriptomics;Translating;translational impact;Transplantation;tumor;Validation;Work;wound;wound closure;wound healing;Wound models

PROJECT_TITLE: Wound healing mechanisms by distinct oral fibroblast population

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: AA

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_NAME: UNIVERSITY OF MISSOURI-ST. LOUIS

PHR: 8. Project Narrative Alcohol use increases the risk for treatment dropout, relapse, and overdose in patients receiving opioid agonist treatment for opioid use. This project will develop and evaluate a modified alcohol-focused intervention tailored to address alcohol use in patients in opioid agonist treatment who are struggling with alcohol use disorder. This brief and scalable tailored intervention will have the potential to decrease alcohol use and improve opioid agonist treatment outcomes with minimal resources, adding in an innovative way to efforts to address the ongoing opioid overdose crisis in the United States.

PI_NAMEs: CARPENTER, RYAN W (contact)

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Alcohol abuse;Alcohol consumption;alcohol intervention;alcohol related problem;alcohol use disorder;Alcohols;Attention;Behavior Therapy;Buprenorphine;buprenorphine treatment;Clinic;Cognitive Therapy;cost;COVID-19 pandemic;Development;drinking;Dropout;effective therapy;Enrollment;Feedback;Focus Groups;follow-up;Goals;improved;Individual;individualized medicine;innovation;Intervention;intervention effect;Intervention Studies;Interview;Knowledge;Lead;Letters;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Modification;motivational enhancement therapy;Nurse Practitioners;Opioid;opioid agonist therapy;opioid epidemic;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;overdose risk;Participant;Patient Self-Report;Patients;peer support;Persons;Physicians;Population;Professional counselor;Protocols documentation;Provider;Public Health;Randomized;randomized, clinical trials;recruit;reduced alcohol use;Relapse;Reporting;Research;Research Personnel;Resources;Risk;Rural;Sampling;Specialist;Structure;suburb;theories;Therapeutic Intervention;therapy development;Time;Training;treatment as usual;Treatment outcome;treatment risk;United States;urban setting;Variant;Work

PROJECT_TITLE: Developing a modified brief alcohol-focused intervention tailored for patients with alcohol use disorder in opioid agonist treatment

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative We recently discovered that reducing collagen expression from gliomas has a major effect on tumor progression and malignant behavior. We now propose to analyze a poorly understood collagen receptor, i.e., LAIR-1, which is expressed on glioma cells and on infiltrating immune cells. We will explore the mechanisms by which LAIR-1 simultaneously controls tumor growth, invasion, and which mediate inhibition of anti-glioma immunity; we will also explore the potential therapeutic benefit of inhibiting LAIR-1 signaling in glioma.

PI_NAMEs: LOWENSTEIN, PEDRO R. (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Affect;Affinity;angiogenesis;anti-tumor immune response;B-Lymphocytes;Behavior;Binding;Biochemical;Bone Marrow;Brain Neoplasms;brain tissue;cancer cell;CD8-Positive T-Lymphocytes;Cell-Mediated Cytolysis;Cells;chemotherapy;Collagen;Collagen Receptors;Complex;cytotoxic;cytotoxicity;DDR1 gene;DDR2 gene;discoidin receptor;Down-Regulation;Excision;extracellular;Extracellular Matrix;Genetically Engineered Mouse;Glioblastoma;Glioma;Goals;Human;Immune;immune activation;immune cell infiltrate;Immune response;Immunity;Immunoglobulin Domain;Immunoglobulins;In Vitro;in vivo;Infiltration;Integrins;Invaded;ITIM;knock-down;leukocyte activation;Leukocytes;Macrophage;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mediating;Membrane Glycoproteins;Microglia;migration;Modeling;monocyte;Natural Killer Cells;neoplastic cell;neuropathology;new therapeutic target;Outcome;Pathogenesis;Pathologic;Patients;Phenotype;Play;Primary Brain Neoplasms;Radiation therapy;receptor;Receptor Protein-Tyrosine Kinases;Recurrent tumor;Renal Carcinoma;response;Role;Signal Pathway;Signal Transduction;Solid Neoplasm;standard of care;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;Tissues;Translations;Treatment Efficacy;tumor;tumor behavior;Tumor Cell Invasion;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;tumor-immune system interactions

PROJECT_TITLE: Role of the collagen receptor LAIR-1 in glioma progression and the tumor immune microenvironment

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE There is growing evidence that defects in myelination, a process that insulates neurons and facilitates brain activity, may be an important aspect of Alzheimer’s disease (AD) pathology. Oligodendrocyte progenitor cells (OPCs) give rise to oligodendrocytes, the myelin-producing cells of the brain, and have recently been shown to become dysregulated during pathology, exhibit toxic functions and shape chronic disease. The current project will investigate how alterations in OPCs and mature oligodendrocytes are affected by two factors closely linked to AD (tau and ApoE4), to shed new light on a novel, disease-causing role for OPCs in AD progression.

PI_NAMEs: COOK, CASEY N (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Affect;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein;Amyloidosis;Apolipoprotein E;apolipoprotein E-4;Automobile Driving;Autopsy;Brain;brain cell;Brain region;brain tissue;Cell Aging;Cell Lineage;Cells;Chronic Disease;Cognitive;Cognitive deficits;Cuprizone;Data Set;Defect;Dementia;Demyelinations;Deposition;Disease;Disease Progression;Excision;Exhibits;Functional disorder;Genetic;genetic approach;Genetic Transcription;Genotype;high risk;Human;in vivo;Inflammation;Injury;insight;Ischemia;LDL-Receptor Related Protein 1;Lesion;Link;Mediating;Methods;Microglia;migration;mild cognitive impairment;Modeling;mouse model;Mus;Myelin;myelination;Neurofibrillary Tangles;Neurons;neuroprotection;novel;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Pathologic;Pathology;Patients;pharmacologic;Population;Process;protective effect;receptor;remyelination;repaired;response;Role;senescence;Senile Plaques;Shapes;single-cell RNA sequencing;Site;stem cells;tau aggregation;tau Proteins;Tauopathies;Toxic effect;Transcription Alteration;transcriptome;white matter;white matter damage;β-amyloid burden

PROJECT_TITLE: Investigating tau and ApoE4-mediated alterations in oligodendrocyte progenitor cells

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Nutrition;Obesity

ORG_CITY: HOUSTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative Crosstalk factors the completion and between white and brown adipose t issues i s key to energy homeostasis, but the underlying crosstalk are poorly understood. This proposal ims to investigate the role of a mitokine, lipocalin-2, in controlling  white to brown fat crosstalk, as well as i ts contribution to whitening of brown adipose tissue. Successful of proposed studies will enhance our understanding of the pathogenesis of brown fat dysfunction obesity and will facilitate discovering novel therapeutics against obesity and its associated comorbidities. a

PI_NAMEs: AN, YU  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Adipocytes;Adipose tissue;Adult;American;Amyloid beta-Protein Precursor;Automobile Driving;Biochemical;Brown Fat;Cardiovascular Diseases;Cell Culture System;Cells;comorbidity;Consumption;Data;diet-induced obesity;Disease;Distress;energy balance;Energy Intake;Energy Metabolism;Epidemic;Fatty acid glycerol esters;Functional disorder;Genes;Goals;Grant;High Fat Diet;Histologic;Homeostasis;Human;Impairment;improved;in silico;In Vitro;in vivo;innovation;Investments;Kinetics;knock-down;Knock-out;Knockout Mice;Knowledge;LCN2 gene;Life;Lipids;Liver;Malignant Neoplasms;Measures;Mediating;Mediator;Mentored Research Scientist Development Award;Metabolic;Metabolic Diseases;Methods;Mitochondria;mitochondrial dysfunction;Modeling;Morphology;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;obesity development;overexpression;Pathogenesis;pharmacologic;Prevalence;Process;Property;Proteins;Public Health;receptor;Recombinant Proteins;Recombinants;Resources;Role;screening;Series;Skeletal Muscle;Testing;Therapeutic;therapeutically effective;Thermogenesis;Tissues;Wild Type Mouse

PROJECT_TITLE: Lipocalin-2, a mitokine that mediates white to brown fat crosstalk

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Serious Mental Illness;Suicide;Violence Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE US suicide rates are rising, and clinicians need to better understand why some people and not others go on from thinking about suicide to acting on their thoughts. We will test the idea that people at risk for suicide fail to make good decisions in a crisis and will investigate why this may happen with decision experiments, brain imaging and mathematical models of decision-making.

PI_NAMEs: DOMBROVSKI, ALEXANDRE Y. (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Address;Affective;Attention;Behavior;Behavioral;Brain imaging;Brain Injuries;Calibration;Clinical;Cognition;Cognitive;cognitive control;computer framework;Computer Models;Computing Methodologies;Data;Decision Making;Depressed mood;design;Deterioration;Disease susceptibility;Dorsal;Emotional;Entropy;experience;experimental study;Failure;Feeling suicidal;forgetting;Functional Magnetic Resonance Imaging;Funding;Heterogeneity;imaging modality;imaging study;Impaired cognition;Impairment;Individual;Information Management;information model;information processing;Intervention;late life;Learning;Life;Maintenance;mathematical model;Mental Depression;National Institute of Mental Health;neural;neural circuit;neuroimaging;neuromechanism;Neurosciences;novel;older adult;Personality;Persons;Populations at Risk;pressure;Process;Protocols documentation;Psychological reinforcement;Psychopathology;Recording of previous events;Reproducibility;Research Domain Criteria;Research Personnel;Research Priority;Resources;response;Rest;Rewards;Risk Management;Sampling;Signal Transduction;Statistical Methods;Study models;suicidal;suicidal behavior;suicidal individual;suicidal risk;Suicide;Suicide attempt;suicide attempter;suicide model;suicide rate;suicide victim;Testing;Theoretical model;theories;Thinking;Time;Uncertainty;Vision;Vulnerable Populations;Work

PROJECT_TITLE: Reward Learning in Late-Life Suicidal Behavior

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Cystic Fibrosis;Emerging Infectious Diseases;Infectious Diseases;Lung;Pediatric;Rare Diseases

ORG_CITY: TEMPE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Recent scientific evidence indicates that Staphylococcus aureus small colony variants are contributing to lung function decline and other poor outcomes in persons with cystic fibrosis (CF) lung infections. The standard-of- care for detecting lung pathogens in CF is by culturing sputum, but new CF therapies make it more difficult for patients to produce sputum, although their risk of lung infection is still high. The aim of this project is to identify breath biomarkers of S. aureus small colony variants and methicillin resistance (MRSA) that would enable the non-invasive and rapid detection of these infections in patients that can’t produce sputum.

PI_NAMEs: BEAN, HEATHER DENISE (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Biological Markers;biomarker panel;Breath Tests;Bronchoalveolar Lavage;Caring;Cause of Death;Child;children with cystic fibrosis;Chronic;Classification;Clinical Research;clinically relevant;co-infection;Collection;Culture-independent methods;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Data Correlations;design;Detection;detection test;Diagnosis;diagnostic accuracy;diagnostic tool;Disease Progression;effective therapy;Etiology;Face;Goals;high risk;Human;improved;In Vitro;in vivo evaluation;Infection;Link;Lung infections;lung pathogen;Measures;metabolome;Metagenomics;Methicillin;Methicillin Resistance;methicillin resistant Staphylococcus aureus;methicillin susceptible Staphylococcus aureus;Methods;microbial;mortality;mortality risk;mouse model;Non-Invasive Detection;noninvasive diagnosis;novel;oropharyngeal swab;Outcome;Patient-Focused Outcomes;Patients;Persons;Phenotype;Play;Population;Predictive Value;Predisposition;Production;prospective;Pseudomonas aeruginosa;Pulmonary Cystic Fibrosis;pulmonary function;pulmonary function decline;Pulmonary Inflammation;rapid detection;recruit;Research;Resistance to infection;Respiratory Failure;Respiratory Tract Infections;Risk;Role;Sampling;Sensitivity and Specificity;Shotguns;Specimen;Sputum;standard of care;Staphylococcus aureus;Staphylococcus aureus infection;Techniques;Testing;Thymidine;Variant;Volatilization

PROJECT_TITLE: Identifying breath biomarkers for S. aureus methicillin resistance and small colony variants

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Genetics;Human Genome

ORG_CITY: GAINESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: We have shown that disruption of the muscle circadian clock mechanism through loss of the core clock gene, Bmal1, is sufficient to induce significant muscle weakness and surprisingly, increased mortality. Based on these findings, the overall objective of this grant is to pursue the fundamental understanding of the role of the muscle circadian clock in regulating a daily program of gene expression and how clock disruption leads to significant muscle weakness and diminished systemic health.

PI_NAMEs: ESSER, KARYN A (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: 3-Dimensional;adeno-associated viral vector;adenovirus mediated delivery;Adult;Aging;Antibodies;ARNTL gene;Attention;Binding;Bioluminescence;ChIP-seq;Chromatin;Chronic Disease;circadian pacemaker;cofactor;connectin;Coupled;Data;DNA Binding;Dose;Elements;epigenomics;Exhibits;experimental study;extend lifespan;Female;functional outcomes;Gene Expression;Genes;Genetic;Genome;Genomics;Grant;Health;improved;Knockout Mice;Length;life span;Link;loss of function mutation;male;Measures;Messenger RNA;metabolomics;Microfilaments;Modeling;Molecular;mortality;mouse model;Muscle;Muscle function;muscle strength;Muscle Weakness;Muscular Atrophy;Myopathy;Outcome;Output;Pathology;Phenotype;Physiological;programs;promoter;Property;Proteins;Regulation;RNA Splicing;Role;Sarcomeres;Site;Skeletal Muscle;Structure;superresolution microscopy;Techniques;Testing;Thick Filament;Tissues;transcription factor;transcriptome sequencing;transcriptomics;translational approach

PROJECT_TITLE: Circadian Clock and Muscle Health

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: DALLAS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: We aim to develop KRAS allele-specific cancer therapies by studying the contributions of specific KRAS mutations to cancer signaling and use that information to develop novel biomarker-driven treatment regimens. This grant will focus on KRAS codon 146 mutations, which have a unique mode of activation by enhanced nucleotide exchange. These mutations are found in colorectal cancer and liquid tumors.

PI_NAMEs: WESTOVER, KENNETH  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Affinity;Alleles;Allosteric Regulation;Binding Sites;Biochemical;biomarker driven;cancer clinical trial;cancer therapy;Chemicals;Clinic;clinical practice;clinical translation;Codon Nucleotides;colon cancer patients;Colorectal Cancer;Complex;Development;Disease;drug discovery;Epidermal Growth Factor Receptor;ERBB2 gene;Exclusion Criteria;Future;genetic approach;Goals;Grant;Guanine Nucleotide Exchange Factors;Guanine Nucleotides;Guanosine Triphosphate;Human;Hydrolysis;Hyperactivity;individualized medicine;inhibitor;Intervention;kinase inhibitor;KRAS2 gene;Libraries;Liquid substance;magnesium ion;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;member;Molecular Conformation;mutant;Mutation;mutational status;Noonan Syndrome;novel marker;Nucleotides;Oncogenic;Patients;phosphoproteomics;Phosphotransferases;Property;Proteins;Ras Signaling Pathway;Roentgen Rays;routine screening;Signal Transduction;Signal Transduction Pathway;Site;small molecule;Structure;synthetic lethal interaction;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Transgenic Mice;translational therapeutics;Treatment Protocols;tumor;Work

PROJECT_TITLE: Characterization and targeting of rapid nucleotide exchange RAS mutations

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Stroke is the second cause of death worldwide and a major cause of disability. This application seeks to advance our understanding of the role of intestinal microbial flora, which is a well- established regulator of the immune system, in stroke-induced brain damage. These studies have the potential to develop new approaches to prevent and treat stroke based on modulating the composition of gut microbes through probiotic and dietary interventions.

PI_NAMEs: ANRATHER, JOSEF  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;adaptive immunity;Affect;Biological Response Modifiers;Brain;brain cell;Brain Injuries;Brain Ischemia;Cause of Death;CD4 Positive T Lymphocytes;Cells;cellular targeting;Cerebral Ischemia;cerebral ischemic injury;Clinical Trials;Coculture Techniques;commensal bacteria;commensal microbes;Dendritic Cells;Development;Dietary Intervention;disability;Disease;Epithelium;Equilibrium;Functional disorder;Goals;gut bacteria;gut microbes;gut microbiota;Histologic;Human;Immune;immune cell infiltrate;Immune response;Immune system;Immunity;immunological status;immunoregulation;Immunosuppression;In Vitro;in vivo Model;infection risk;Inflammation;Inflammatory;Inflammatory Response;Interleukin 6 Receptor;Interleukin-6;Interphase;Intestinal Content;Intestines;Ischemia;Ischemic Brain Injury;ischemic injury;Ischemic Stroke;ITGAX gene;Lymphocyte;lymphoid organ;Maintenance;Mediating;Mediator;Meninges;microbial;microbial composition;microbiome;microbiota;microbiota-gut-brain axis;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mouse model;Mus;Natural Immunity;Neurological outcome;neuroprotection;novel strategies;Pathologic Processes;Pathology;Pathway interactions;Peripheral;Phenotype;Play;Population;post stroke;Probiotics;programs;receptor;recruit;Regulatory T-Lymphocyte;repaired;Reporter;Research;Rodent;Role;Route;Shapes;Signal Pathway;Signal Transduction;Small Intestines;Stroke;stroke outcome;stroke patient;Stroke prevention;stroke risk;stroke therapy;success;Surface;T cell differentiation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;tissue injury;Tissues;trafficking;Transforming Growth Factor beta;transmission process;γδ T cells

PROJECT_TITLE: The Role of Dendritic Cells in Regulating the Gut-Brain Immune Axis in Ischemic Stroke

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ORG_CITY: BOSTON

ORG_NAME: JOSLIN DIABETES CENTER

ORG_STATE: MA

PHR: Narrative  This is a renewal of NIH grant DK031036 which is focused on the insulin and IGF-1 receptors, their signaling pathways and their alterations in physiologic and pathologic states. Over the past decade, we have made tremendous progress in understanding the signaling and biological roles of these receptors through both in vitro and in vivo studies, including extensive studies using gene targeting to create over a dozen models with single, combinatorial and tissue-specific knockouts of insulin and IGF-1 receptors to determine their role in normal physiology and the pathophysiology of disease. During the coming grant period, our aims are to continue to expand our understanding of insulin/IGF1 action by 1) defining the differential roles of the extra- and intra-cellular domains of IR and IGF1R in signaling in vitro and in vivo; 2) determining the nature of signaling by the unoccupied insulin and IGF-1 receptors involved in control of gene expression, autophagy and apoptosis and 3) continuing to determine the role of insulin signaling in brain on astrocytes vs neurons and the role insulin resistance in brain in pathogenesis of Alzheimer’s Disease.

PI_NAMEs: KAHN, C RONALD (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Alzheimer's Disease;Apoptosis;Astrocytes;Autophagocytosis;Biological;Brain;cell type;Cells;combinatorial;Communication;Complex;Core Grant;Diabetes Mellitus;Disease;Endothelium;Extracellular Domain;Functional disorder;Gene Expression;Gene Expression Regulation;Gene Targeting;Generations;Genetic Risk;Grant;homologous recombination;IGF1 gene;IGF1R gene;In Vitro;in vivo;Individual;induced pluripotent stem cell;insight;Insulin;Insulin Receptor;insulin regulation;Insulin Resistance;insulin signaling;Insulin-Like Growth Factor I;insulin-like peptide;Insulin-Like-Growth Factor I Receptor;Intestines;Knock-in Mouse;Knock-out;Link;Mass Spectrum Analysis;Mediating;Metabolic Diseases;Metabolic syndrome;Modeling;mouse model;mutant;Nature;Neurodegenerative Disorders;Neurons;novel;Organ;Paper;Pathogenesis;Pathologic;phosphoproteomics;Physiological;Physiology;Property;Proteins;Proteomics;Publishing;receptor;Receptor Signaling;Receptor-Interacting Protein;Role;Signal Pathway;Signal Transduction;Signaling Protein;Structure;System;Tissues;United States National Institutes of Health;Viral;Virus;Work

PROJECT_TITLE: Insulin Receptor Structure and Turnover

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


NIH_SPENDING_CATS: Wound Healing and Care

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: A thorough understanding of cells and molecules that regulate tissue fibrosis is essential for the generation of tissue-specific regenerative therapies to effectively treat human disease. Since the manner in which adipocytes function during skin fibrosis is largely unknown, we will define how these major but poorly understood cells function during fibrosis using mouse models and human patient cells in culture. Our work will improve our understanding of the cells and molecules that control fibrosis development, how adipocytes function in this disease progression, and will have global relevance for other tissues like heart and lung that undergo fibrosis.

PI_NAMEs: ATIT, RADHIKA P;HORSLEY, VALERIE  (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Acceleration;adipocyte biology;Adipocytes;Adipose tissue;Aggressive Fibromatosis;Atopic Dermatitis;Biological Assay;Biology;Bleomycin;Cell Physiology;Cell Therapy;cell type;Cells;Cessation of life;Chemical Models;Chemicals;Chronic;Cicatrix;Clinical;Collaborations;cytokine;Data;Deposition;Dermal;Dermis;Development;dietary;Dipeptidases;Disease;Disease Progression;efficacious treatment;Europe;Event;experimental study;Extracellular Matrix Proteins;Fatty Acids;Felis catus;Fibroblasts;Fibrosis;Generations;Genetic;Genetic Models;Genomics;Goals;healing;Heart;Histologic;Human;human disease;Hypertrophic Cicatrix;Immunologics;Immunomodulators;improved;In Vitro;in vivo;in vivo Model;indium-bleomycin;insight;Keloid;Kinetics;Laboratories;Lipase;lipidomics;Lipids;Lipodystrophy;Lipolysis;Lung;Modeling;Molecular;mouse model;Mus;new therapeutic target;novel;Organ;Participant;Pathologic;Pathway interactions;Patients;personalized medicine;prevent;Process;Production;Profibrotic signal;Proteomics;regenerative therapy;Repression;response;Role;Scleroderma;Sclerosis;Signal Induction;Signal Pathway;Signal Transduction;Skin;skin fibrosis;skin organogenesis;Stimulus;Testing;Therapeutic Intervention;therapeutic target;Tissues;uptake;WNT Signaling Pathway;Work

PROJECT_TITLE: Mechanism and Impact of Dermal adipocyte remodeling in skin fibrosis


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: LARAMIE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: Project Narrative Coxiella burnetii, the intracellular bacterial pathogen the causes Q fever, has few described virulence factors outside of its Type IVb Secretion System and lipopolysaccharide. Using a unique cellular model of Coxiella infection, we discovered that multiple genes related to the bacterial cell wall are specifically required for replication in primary macrophages. These genes represent a novel class of cell type-specific virulence determinants for C. burnetii.

PI_NAMEs: CASE, ELIZABETH DI RUSSO (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Acute;Affect;Alveolar Macrophages;Anti-Bacterial Agents;Anti-Inflammatory Agents;Antibiotic Therapy;Attenuated;Bacteria;Bacterial Infections;Biochemical;Biological;Biological Assay;Cell model;cell type;Cell Wall;Cells;Characteristics;Chronic;Chronic Disease;chronic infection;Complement;Coxiella;Coxiella burnetii;Data;defined contribution;design;Development;Effector Cell;Endocarditis;Environment;experimental study;Foundations;gene product;Genes;Genetic;Genetic Screening;Genetic Transcription;genomic locus;Goals;Hour;Immune;Immune response;In Vitro;Individual;Infection;Infection Control;Inflammatory;Link;Lipids;Lipopolysaccharides;Macrophage;Measures;Membrane;microbicide;Modeling;Molecular;Morphology;mutant;novel;Organelles;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Peptidoglycan;Phagolysosome;Phenotype;polarized cell;programs;Proliferating;Q Fever;Research;resilience;Resistance;respiratory;response;Role;Screening Result;Series;Stress;Structure;System;trafficking;transcriptome sequencing;transposon sequencing;Vacuole;Vero Cells;Virulence;Virulence Factors;virulence gene

PROJECT_TITLE: Investigating the Contribution of the Coxiella Cell Wall to Intracellular Pathogenesis

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Cystic Fibrosis;Lung;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Sleep Research

ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative We have published that CR gene expression patterns are altered in CF and that microtubule-dependent mechanisms can influence CR regulation. The purpose of this study is to further define the relationship and mechanisms linking absent CFTR and CR dysregulation and examine the efficacy of highly-effective modulator therapy on CR.

PI_NAMEs: DARRAH, REBECCA J;KELLEY, THOMAS J (contact)

PROJECT_TERMS: Acetylation;actigraphy;Address;Adolescent;Adolescent and Young Adult;Age;Anxiety;Automobile Driving;behavioral outcome;Biogenesis;Biological Process;Cells;Child;children with cystic fibrosis;circadian;Circadian Dysregulation;Circadian Rhythms;Clinical Data;clinical development;clinically relevant;Cystic Fibrosis;cystic fibrosis mouse;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Delta F508 mutation;Dependence;Digestive System Disorders;Disease;Disease Progression;efficacy evaluation;efficacy testing;Eligibility Determination;Exhibits;experience;Functional disorder;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Generations;Genotype;Goals;Growth;healthy volunteer;Human;Impairment;Inbred CFTR Mice;insight;Knock-out;Knockout Mice;Lead;Link;Lung Diseases;Melatonin;Mental Depression;Microtubule Alteration;Microtubules;Morbidity - disease rate;mortality;mouse model;Mus;Outcome;Pathway interactions;Patients;Pattern;pediatric patients;Phase;Phenotype;Play;polymerization;Polymers;poor sleep;Process;Production;Proteins;Publishing;Regulation;Reporting;Respiratory Disease;Role;Sleep;Sleep disturbances;sleep pattern;sleep quality;sleep regulation;Source;Symptoms;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;therapy development;Time;Tryptophan Metabolism Pathway;Tubulin;young adult

PROJECT_TITLE: Altered Circadian Rhythm Regulation in Cystic Fibrosis

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: OMAHA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Educational programs to underserved communities serve many purposes. Exposure to hands on science lessons, ideas related to healthy living, and missions of the National Institutes of Health will supplement their classroom pedagogy. The community outreach will increase awareness of health and science professions among Native American populations and help to bridge the significant gap in health and education disparities.

PI_NAMEs: BRONNER, LILIANA ;GODFREY, MAURICE  (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: Acceleration;Achievement;after-school program;Age;American Indians;aspirate;Attitude;Award;Awareness;Back;career;Chairperson;Communication;Communities;Community Outreach;design;Development;Disparity;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Elderly;Elements;Evaluation;experience;Exposure to;Fostering;Foundations;Future;Goals;Great Plains;Health;health literacy;Health Professional;Health Sciences;High School Student;implementation facilitation;improved;Indian reservation;Instruction;Intention;interest;junior high school;Learning;Length;literate;Living Wills;Mathematics;Measures;Medical center;Mentors;Mentorship;Middle School Faculty;Middle School Student;Mission;Motivation;Native American community;Native American population;Native Americans;native youth;Nebraska;novel;outreach;Parents;Participant;pedagogy;posters;preservation;Primary School Faculty;Program Development;programs;Questionnaires;Research;Research Technics;Resources;Role;role model;Schools;Science;science education;Services;Site Visit;skills;South Dakota;student participation;Students;success;summer program;Summer science program;Surveys;teacher;teacher mentor;Teacher Professional Development;Testing;Training;tribal community;Tribal Council;Tribal School;Tribes;Trust;underserved community;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Encouraging Excellence: Health Science Education in Native American Communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Clinical Research;Prevention;Social Determinants of Health

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative In the proposed project entitled, “2/2-GEOHealth Health Effects of Selected Environmental Exposomes Across the Life CourSe (HEALS)-US” we have assembled a multidisciplinary group of researchers, mentors, and program faculty from the Harvard T.H. Chan School of Public Health (HSPH) and the Centre for Chronic Disease Control (CCDC) to build the capacity of public health professionals in India to generate data needed to address the unique characteristics of exposures in India. Our goal is to build scientific capacity in India to conduct high quality research and gain knowledge that can be translated into policy improvements. We will advance capacity by providing a robust platform of training programs for postdoctoral, early- career and short-term researchers, Doctor of Public Health training at HSPH, curricula that benefit current researchers and support the development of a Master’s of Science in Environmental Health program in Indian Institutes of Public Health, and support for CCDC faculty involved in the U01 to complete mentored research activity at HSPH.

PI_NAMEs: PRABHAKARAN, DORAIRAJ ;REDDY, SRINATH K;SCHWARTZ, JOEL D;SIEBER, NANCY CAROL L. (contact)

PROGRAM_OFFICER_NAME: JESSUP, CHRISTINE

PROJECT_TERMS: Acute;Address;Affect;Age;Air Pollution;burden of illness;Cardiac;Cardiometabolic Disease;Cessation of life;Child;Chronic;Chronic Disease;Cities;climate change;Complex;Country;design;Development;disability-adjusted life years;disorder control;Doctor of Public Health;early-career faculty;Elements;Environmental Exposure;Environmental Health;Event;experience;Exposure to;Faculty;fine particles;Foundations;Funding;Future;Gender;Government Agencies;Health;Heat Waves;Human Resources;India;Individual;Industry;Knowledge;Learning;Life Cycle Stages;Link;low and middle-income countries;Master of Science;Mentors;Modeling;multidisciplinary;Occupations;older adult;Persons;Policies;Policy Maker;Pollution;Postdoctoral Fellow;premature;programs;Public Health;Public Health Schools;Public Health Students;Recommendation;Research;Research Personnel;research study;Scientist;Socioeconomic Status;Students;Training;Urbanization;Vulnerable Populations;Writing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Q(70)R]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Immunotherapy;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARATIVE This study will examine a novel immune-modulatory mechanism through which statins impede the progression of lethal prostate cancer. The research plan includes the construction of tumor microarray (TMA) set from a clinical cohort of men sampled based on their statin use at the time of prostatectomy, and a proof-of-principle pre-prostatectomy randomized trial to test the effect of statins on this pathway in men diagnosed with prostate cancer schedule for prostatectomy. The research project is complemented by a comprehensive training program that will prepare the applicant for an independent research career as a translational cancer epidemiologist.

PI_NAMEs: MARRONE, MICHAEL THOMAS (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Adjuvant;advanced prostate cancer;anti-cancer research;anti-tumor immune response;Area;Biological;Biology;biomarker validation;cancer biomarkers;Cancer Control;cancer epidemiology;career;CD8B1 gene;Cell Physiology;Cells;Cessation of life;Characteristics;Chemopreventive Agent;Clinical;Clinical Trials;Clinical Trials Design;cohort;Collaborations;Controlled Environment;Cytoplasm;density;Development;Diagnosis;Disease;Dose;Drug usage;Epidemiologic Methods;Epidemiologist;Epidemiology;epidemiology study;evidence base;experience;Foundations;FOXP3 gene;Functional disorder;Genetic Transcription;Goals;Health;Helper-Inducer T-Lymphocyte;Heterogeneity;Immune;Immune response;immunoregulation;Immunosuppression;Immunotherapy;improved;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Mediating;Medical Oncology;Meditation;men;Mentors;Methods;Molecular;multidisciplinary;Nature;Neoplasm Metastasis;novel;Nuclear Protein;Nuclear Translocation;Observational Study;oncology trial;Operative Surgical Procedures;Outcome;Pathologic;Pathway interactions;Pharmaceutical Preparations;Pharmacology;Phase;Phosphorylation;Placebos;pleiotropism;population based;population health;progression risk;Prostate;prostate cancer progression;Prostate Cancer therapy;Prostatectomy;Prostatic Neoplasms;protective effect;Proteins;Randomized;randomized trial;Regulatory T-Lymphocyte;Research;Research Project Grants;response;Risk;Risk Reduction;Sampling;Schedule;Science;T cell response;Testing;Therapeutic;Time;tissue archive;tissue biomarkers;Tissue Microarray;Tissues;Training;Training Programs;Translations;tumor;Tumor Antigens;tumor microenvironment;Uncertainty;validation studies;Work

PROJECT_TITLE: Treg functional changes: a novel immune regulatory effect underlying the benefit of statin drug use on lethal prostate cancer


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Rare Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE The current study will examine correlations between T cell senescence and the severity and progression of sporadic inclusion body myositis (IBM). Further, the capacity of senolytic drugs to inhibit or ablate senescent IBM T cells will be evaluated. The proposed studies promise to advance our understanding of the role of T cells in IBM and provide mechanistic insight on the regulation of T cell senescence in IBM muscle.

PI_NAMEs: VILLALTA, SERGIO ARMANDO (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Ablation;Address;Affect;Age;age-related disease;Apoptosis;Autoimmunity;beta-Galactosidase;Biological Assay;Biopsy Specimen;Blood;Blood specimen;Cardiovascular system;CD8-Positive T-Lymphocytes;CD8B1 gene;CDKN1A gene;CDKN2A gene;Cell Aging;Cell Death;Cell Physiology;Cells;Cessation of life;Characteristics;Circulation;Clinical;Clinical Trials;Clinical Trials Design;Clonal Expansion;Cytometry;Data;Development;disability;Disease;Disease Progression;efficacy testing;Etiology;Exhibits;Flow Cytometry;Foundations;Frequencies;Funding;Future;Goals;Granzyme;high dimensionality;illness length;Image;imaging platform;Immune response;Immune system;Immunotherapy;In Vitro;Inclusion Body Myositis;Inflammatory;innovation;insight;Interferon Type II;Investigation;Knowledge;Measures;Molecular;Muscle;Muscle Cells;Muscle Weakness;Myopathy;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural History;Nature;Neurology;novel marker;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;Parents;Pathogenesis;patient stratification;Patients;perforin;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;Predisposition;Prevalence;Production;Proteins;Rare Diseases;Refractory;Reporting;Research;Resistance;Resolution;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Severities;Severity of illness;Skeletal Muscle;Sporadic Inclusion Body Myopathy;T cell differentiation;T cell regulation;T cell response;T memory cell;T-Lymphocyte;Testing;Therapeutic;Time;Tissues;tool;United States;United States National Institutes of Health;Work

PROJECT_TITLE: High-dimensional mass imaging of muscle for the mechanistic study of T cells in inclusion body myositis


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Natural Products;Orphan Drug;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Cryptosporidium is a water-borne parasite that causes diarrheal disease that in immuno- compromised people can be severe and sometimes fatal. There is no drug to effectively treat cryptosporidiosis. In this application we will study a group of related natural product fungal metabolites that inhibit Cryptosporidium to identify an optimal compound that can be developed into a clinical therapeutic.

PI_NAMEs: O'CONNOR, ROBERTA M;SALOMON, CHRISTINE E (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: 2 year old;Acquired Immunodeficiency Syndrome;Adult;Affinity;analog;Antiparasitic Agents;Artemisinins;Bioinformatics;Biological Assay;Biology;Caco-2 Cells;Cells;Cessation of life;Child;Chronic;Clinical;Clinical Trials;Complement;Cryptosporidiosis;Cryptosporidium;cytotoxicity;Data;Developing Countries;Development;Diarrhea;diarrheal disease;Disease;Disease Outbreaks;Dose;Drug Kinetics;Exhibits;Experimental Genetics;Exploratory/Developmental Grant;Fatigue;forward genetics;Fungal natural products;fungus;gastrointestinal;genetic approach;grasp;Growth;high risk;Homologous Gene;immune reconstitution;Immunocompromised Host;Immunosuppression;improved;in vitro testing;in vivo;indexing;Individual;Infection;Iron;Ivermectin;Lactones;Liver Microsomes;marine organism;Minnesota;Minor;Molecular Target;Mus;nanomolar;Natural Products;Nausea;new therapeutic target;Norditerpenoids;novel therapeutics;opportunistic pathogen;Oral;Parasites;Parasitic Diseases;pathogen;Permeability;Persons;Pharmaceutical Preparations;pharmacophore;Plasma;preclinical study;Property;scaffold;screening;Series;Structure-Activity Relationship;success;Technology;Testing;Therapeutic;therapeutic development;therapeutically effective;Toxoplasma;Toxoplasmosis;waterborne;waterborne outbreak

PROJECT_TITLE: Antiparasitic metabolites from deep subterranean fungi for the treatment of cryptosporidiosis, an AIDS defining disease

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: GALVESTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on identifying previously unknown molecular mechanisms mediating abnormal synaptic communication triggered by soluble oligomers in Alzheimer’s disease, and the modifications of those mechanisms which ultimately promote synaptic protection in people resilient to soluble oligomers effects. This is expected to provide new knowledge about potential targets of pharmacological intervention and drive the development of a novel, effective therapy for AD, thus improving these patients’ health while driving down the societal cost for their care. The proposed research is relevant to the part of NIH’s mission concerned with fostering creative discoveries and their application to advance the Nation’s capacity to protect and improve health.

PI_NAMEs: LIMON, AGENOR  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Ablation;Affect;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease therapy;AMPA Receptors;Amyloid;Animal Model;Automobile Driving;Autopsy;Binding;Brain;brain control;Caring;case control;Clinical;Clinical Trials;Cognitive;cognitive control;cohort;Communication;Complex;Creativeness;Data;Data Set;Dementia;Development;effective therapy;efficacy evaluation;Electrophysiology (science);Fostering;Foundations;Future;Gene Expression;Genetic;Glutamate Receptor;glutamatergic signaling;Glutamates;Goals;Health;Human;improved;Individual;Inferior;innovation;Intervention;Ions;Knowledge;Lead;Literature;Mediating;Mission;Modification;Molecular;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;neuropathology;non-demented;novel;novel strategies;Parietal Lobe;Pathology;Patients;Permeability;Persons;Pharmacodynamics;pharmacologic;Pharmacology;Post-Translational Protein Processing;preservation;promote resilience;protein expression;Proteins;Public Health;Publishing;receptor;Research;resilience;response;Role;Signal Transduction;societal costs;Synapses;synaptic failure;synaptic function;Synaptic Membranes;Synaptic Receptors;System;tau aggregation;tau Proteins;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Transplantation;treatment center;United States National Institutes of Health;Work

PROJECT_TITLE: Mechanisms of Synaptic Protection in Cognitive Resilence to Alzheimer's Disease Neuropathology

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE The goal of this proposal for a P50 Center is to is to expand existing strengths and expertise in Nebraska to develop a novel niche in alcohol research, by creating a Center focused on the Alcohol Exposome. We hypothesize that under the comprehensive schema of the exposome, alcohol represents an environmental exposure that should be considered in context with other internal and external factors to understand the etiology of disease and the subsequent manifestation of alcohol pathophysiology.

PI_NAMEs: CASEY, CAROL A. (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Address;adduct;Age;Aging;Alcohol consumption;alcohol effect;alcohol misuse;alcohol research;Alcoholic Fatty Liver;Alcoholic Liver Diseases;Alcohols;Aldehydes;animal tissue;Animals;Area;Bacterial Pneumonia;Basic Science;Biology;Brain;Categories;cell injury;Cell model;Cigarette;cigarette smoking;clinical translation;Collaborations;college;comorbidity;Dedications;Development;Disease;Disease Progression;Environment;Environmental Exposure;Environmental Risk Factor;Etiology;Event;Exposure to;Faculty;Foundations;Functional disorder;Funding;Funding Opportunities;Future;Goals;Grant;Health;Heart Injuries;Hepatic;Hepatitis B Infection;Human;human tissue;Immune;Immunity;Incidence;Individual;Infection;insight;Institution;Interdisciplinary Study;Investigation;Knowledge;lifestyle factors;Liver;liver injury;Lung;Marijuana Smoking;Medical center;member;metal metabolism;Molecular;multidisciplinary;multiorgan damage;National Institute on Alcohol Abuse and Alcoholism;Natural Immunity;Nature;Nebraska;novel;Nutritional;Nutritional status;Obesity;Occupational;Organ;pathogen;Physiology;Pilot Projects;Predisposition;problem drinker;protein transport;recruit;Research;Research Personnel;Research Project Grants;Resources;Role;Scientist;Services;Shapes;Signal Transduction;Structure;symposium;Talents;tissue injury;Tissue Model;Tobacco;Toxin;Trace metal;Training;training opportunity;Translating;Translational Research;United States;United States Department of Veterans Affairs;Universities;Work;Zinc deficiency

PROJECT_TITLE: Alcohol Center Of Research -- Nebraska (ACORN)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

PROJECT_TERMS: Address;Advisory Committees;Age;Alcohol consumption;alcohol research;Alcohols;Appointment;Biometry;Budgets;cigarette smoking;Communication;Communities;conflict resolution;Contracts;Educational workshop;Environment;Evaluation;Event;Fatty acid glycerol esters;Gastroenterology;Goals;Government Agencies;Hepatology;Individual;Infection;Information Technology;Institution;Institutional Review Boards;Intake;Internal Medicine;Leadership;Logic;Lung;meetings;Mission;Modeling;Monitor;multidisciplinary;Nebraska;nutrition;Organ;organizational structure;outreach;Pilot Projects;programs;Public Relations;Records;recruit;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Resources;Services;social media;Strategic Planning;Structure;symposium;Use Effectiveness;Viral;Vision;web site;Zinc deficiency

PROJECT_TITLE: ACORN: Administrative and Planning Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: NOTRE DAME

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project Narrative  New classes of bright and stable fluorescent dyes will be developed and converted into valuable molecular probes for biomedical imaging. The fluorescent molecular probes will be used for advanced microscopy studies of cells, in vivo imaging of animal models of cancer and glaucoma, and emerging clinical imaging procedures such as fluorescence guided surgery and rapid pathology. In some cases, biomedical researchers will be able to synthesize their own molecular probes using a machine, thus greatly facilitating the clinical translation process.

PI_NAMEs: SMITH, BRADLEY D (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Animal Cancer Model;Animal Disease Models;biomedical imaging;Cells;Clinical;clinical imaging;clinical translation;Collaborations;contrast imaging;cyanine;design;Diagnostic;Drug Kinetics;Dyes;Endosomes;Ensure;exosome;Fluorescence;fluorescence imaging;fluorescence-guided surgery;Fluorescent Dyes;Fluorescent Probes;Glaucoma;Health Status;Image;Image Enhancement;Imaging Techniques;implantable device;improved;in vivo fluorescence imaging;in vivo imaging;innovation;interest;Label;Light;Lipids;Medical;Methods;Microscopy;Molecular;Molecular Probes;nanoscale;near infrared dye;Oligonucleotide Probes;Oligonucleotides;Operative Surgical Procedures;Pathology;Patient imaging;Peptides;Performance;polyhistidine;pre-clinical;preclinical imaging;Procedures;Process;Property;Proteins;Protocols documentation;Reporting;Research;Research Personnel;Science;single molecule;Structure;superresolution microscopy;Techniques;Time;trafficking;Translation Process;Vendor;Virus Diseases;Work

PROJECT_TITLE: Molecular Probes for Biomembrane Recognition

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


PI_NAMEs: WYATT, TODD A (contact)

PROJECT_TERMS: Address;Advisory Committees;Alcohol consumption;alcohol misuse;alcohol research;Alcohols;Applications Grants;Area;Attention;college;Communities;Consultations;Data;Disease;Effectiveness;evidence base;Feasibility Studies;Funding;Funding Agency;Funding Opportunities;Future;Goals;Grant;Health;human disease;Injury;innovation;Internal Medicine;Lead;Leadership;Letters;Medical center;Medicine;meetings;Mission;Monitor;National Institute on Alcohol Abuse and Alcoholism;Nebraska;Peer Review;Periodicals;Pilot Projects;Preparation;Prevention strategy;Principal Investigator;programs;Public Health;Publishing;Reporting;Request for Applications;Research;Research Personnel;Research Project Grants;Review Literature;Series;STEM research;success;symposium;Testing;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: ACORN Pilot Core


PI_NAMEs: MCVICKER, BENITA L. (contact)

PROJECT_TERMS: Age;Alcohol consumption;alcohol effect;Alcohols;Animal Model;animal tissue;Animals;Archives;Behavior;biobank;bioimaging;Biological Markers;Biological Models;bronchial epithelium;Cell model;Cells;Characteristics;Collaborations;Collection;computerized data processing;Contracts;Core Facility;Data;Data Collection;Data Management Resources;data sharing;design;Development;Diet;Documentation;Education;Electronic Health Record;Ensure;Epithelial Cells;Equipment and supply inventories;Experimental Designs;Fibroblasts;Future;gastrointestinal system;Harvest;Heart;Hepatocyte;Human;human disease;human model;Human Resources;human tissue;In Vitro;Infection;Information Technology;innovation;Liver;Lung;Mesenchymal Stem Cells;Mus;Nebraska;novel;Organ;Organ Procurements;Organoids;Performance;Physiology;Preparation;Procedures;Protocols documentation;Reporting;Research;Research Personnel;Resource Sharing;Resources;Sampling;Secure;Serum;Services;Slice;Smoking;Standardization;Study models;success;System;Therapeutic;Tissue Banks;Tissue Model;Tissue Sample;Tissues;Toxin;Training;Training and Education;training opportunity;translational model;translational research program

PROJECT_TITLE: ACORN: BioCore


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Digestive Diseases;Infectious Diseases;Liver Disease;Lung;Microbiome;Nutrition;Pneumonia;Pneumonia and Influenza;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

PROJECT_TERMS: Acute;Address;Alcohol consumption;alcohol effect;alcohol exposure;alcohol misuse;alcohol research;alcohol use disorder;Alcohols;Aldehydes;American;Animal Model;antimicrobial;Bacteria;Bacterial Infections;Bacterial Pneumonia;Binding;biobank;Blood;bronchial epithelium;career;Cause of Death;Cell model;Cells;Characteristics;Chronic;Chronic Obstructive Pulmonary Disease;Cigarette;cigarette smoke;cigarette smoking;Cilia;cilium motility;Clinical;clinical care;Communication;comorbidity;Complex;Coupled;Defensins;Development;Diagnosis;Disease;Distal;empowerment;Environmental Exposure;Enzymes;Epithelial Cells;Ethanol Metabolism;experience;Exposure to;exposure to cigarette smoke;extracellular vesicles;Functional disorder;Future;General Population;gut dysbiosis;gut microbiome;gut-liver axis;gut-lung axis;Host Defense;Human;Impairment;Incidence;Individual;Infection;Injury;interest;International;Investigation;Knowledge;Laboratories;Life;Liver;liver injury;Lung;Lung Diseases;Lung infections;lung injury;lung repair;Macrophage;Malnutrition;Mediating;Membrane;Metabolic;microbicide;microbiota;Modality;Modeling;Modification;Morbidity - disease rate;mortality;mouse model;Mucociliary Clearance;Mus;Nebraska;novel;Nutrient;nutrition;Nutritional;Older Population;Organ;organ injury;Organoids;Pathogenesis;Pathology;Pharmacy facility;Play;Pneumococcal Pneumonia;Pneumonia;Predisposition;Preventive care;professor;Pulmonary Surfactant-Associated Protein D;Research;Research Personnel;response;Risk;Role;Sampling;Scientist;Severities;skills;Smoke;smoke inhalation;Smoker;Source;Stream;Streptococcus pneumoniae;Sum;surfactant;targeted treatment;Testing;Time;tissue injury;Tissues;tobacco exposure;Vesicle;Zinc;Zinc deficiency

PROJECT_TITLE: The Exposome and Lung Bacterial Infection: Role of Liver and Gut-derived Extracellular Vesicles


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease;Substance Misuse

PI_NAMEs: OSNA, NATALIA ALEKSANDR (contact)

PROJECT_TERMS: Acceleration;Adipose tissue;Affect;Alcohol abuse;alcohol abuser;Alcohol consumption;alcohol effect;alcohol exposure;Alcoholic Liver Diseases;Alcohols;Animal Model;Antigens;APOCEC3G gene;Attenuated;biomarker development;Cells;Chronic Hepatitis B;Circulation;Clinical;clinical practice;Clinical Trials;Communication;Complex;Cytotoxic T-Lymphocytes;Death Rate;Development;end stage disease;end stage liver disease;Environmental Exposure;Ethanol;Event;experience;experimental study;Exposure to;extracellular vesicles;Fatty acid glycerol esters;Fatty Acids;Fatty Liver;Feedback;Functional disorder;Future;gene induction;Genes;Goals;Grant;Heart;Hepatitis B;Hepatocyte;High Fat Diet;Immune;immune activation;Impairment;Incidence;Infection;Inflammation;Interferon Activation;Interferons;Intervention;intrahepatic;IRF3 gene;Liver;liver injury;Lung;Macrophage;Malignant Neoplasms;Mediating;Modality;Monitor;mortality;Mus;Natural Immunity;Nebraska;Organ;Outcome;Pancreas;Pathogenesis;Pathology;Pathway interactions;Patients;pre-clinical;Preventive vaccine;protective effect;Qualifying;RARRES3 gene;Regulation;Research;Research Personnel;Resistance;Resolution;response;Signal Transduction;Spleen;STAT1 gene;Stimulator of Interferon Genes;systemic inflammatory response;Tissues;Transgenic Organisms;Translating;Unsaturated Fatty Acids;vaccine access;Viral;Viral Genes;Viral Load result;Viral Markers;Viral Pathogenesis;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Alcohol Promotes Hepatitis B Progression by Impairment of Innate Immunity in Liver Cells


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Heart Disease;Kidney Disease;Liver Disease;Nutrition;Obesity;Substance Misuse

PI_NAMEs: VISWANATHAN, SARASWATHI  (contact)

PROJECT_TERMS: Affect;Alcohol consumption;Alcohol-Related Disorders;Alcoholic Cardiomyopathy;Alcoholic Liver Diseases;Alcohols;antagonist;Attenuated;Autoimmune Diseases;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;Chronic;chronic alcohol ingestion;chronic inflammatory disease;Collecting Cell;comparison control;conditional knockout;Congestive Heart Failure;Data;Development;Diet;Echocardiography;Eicosanoids;Ethanol;Event;Exposure to;Fatty acid glycerol esters;Fatty Acids;Fatty Liver;feeding;Functional disorder;G-Protein-Coupled Receptors;General Population;Genetic;Habits;Health;Heart;Heart Diseases;heart function;Heart Injuries;Heavy Drinking;hemodynamics;Hepatic;Hepatocyte;High Fat Diet;Human;Impairment;improved;in vivo;Incidence;Individual;Inflammation;Inflammatory;Inflammatory Response;Isoprostanes;Knockout Mice;Link;Linoleic Acids;lipid metabolism;Liver;Liver diseases;liver inflammation;liver injury;Measurement;Measures;Mediating;Metabolic;Mitochondria;mitochondrial dysfunction;Molecular;multiorgan damage;Mus;Myocardial;Nebraska;non-alcoholic fatty liver disease;Nutritional;obese patients;Obesity;Organ;organ injury;oxidant stress;Oxidative Stress;Patients;Peripheral Blood Mononuclear Cell;Polyunsaturated Fatty Acids;Prostaglandins;Rattus;receptor;receptor expression;Reporting;Research;Role;Therapeutic Agents;therapeutically effective;Thromboxane A2;Thromboxanes;Tissues;Triglycerides;Wild Type Mouse

PROJECT_TITLE: The Role of TP-R on Alcohol-Induced Multi-Organ Damage: Liver and Heart


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Microbiome;Nutrition;Substance Misuse

PI_NAMEs: KHARBANDA, KUSUM K. (contact)

PROJECT_TERMS: adipokines;adiponectin;Adipose tissue;Advanced Development;Age;age effect;Aging;aging population;aging related;Alcohol consumption;alcohol exposure;alcohol misuse;alcohol response;Alcoholic Liver Diseases;Alcohols;animal old age;Animals;Bacterial Translocation;biobank;Biological;Body Composition;Body System;Cell Physiology;cell type;Chronic;chronic alcohol ingestion;chronic liver disease;Circulation;Cirrhosis;Clinical;Defect;Development;Diet;diet and exercise;Disease Outcome;disease phenotype;Disease Progression;Dose;drinking;Eating;Elderly;Endothelial Cells;Endotoxins;Energy Metabolism;Ethanol;Exhibits;Experimental Designs;Exposure to;Extrahepatic;Functional disorder;Gastrointestinal tract structure;Gender;Genetic;glucose uptake;gut microbiota;Heavy Drinking;Hepatic;Hepatic Stellate Cell;Hepatocyte;Hormones;Impairment;Inflammation Mediators;insight;Insulin;intestinal barrier;Investigation;juvenile animal;Kupffer Cells;late life;Life Style;Lipolysis;Liver;Liver Circulation;Liver diseases;liver injury;Metabolism;Methods;Morbidity - disease rate;mortality;Motor Activity;Mucous Membrane;Nebraska;Nonesterified Fatty Acids;older patient;Organ;Pathogenesis;Pathogenicity;Pathology;Patients;Pattern;Persons;Physiological;Play;Primary carcinoma of the liver cells;Recording of previous events;Research;Risk Factors;Rodent;Role;Sampling;Severities;Severity of illness;simple steatosis;Steatohepatitis;Structure;Testing;trend;Virus Diseases;Water consumption

PROJECT_TITLE: Development and Progression of Alcohol-Associated Liver Disease: Effect of Aging


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE The goal of this research is to better understand the neurobiological basis of consciousness and its modulation by the anesthetic agents. The project will use cognitive testing, functional magnetic resonance imaging and noninvasive brain stimulation with low intensity focused ultrasound in awake and sedated volunteers. The findings should provide insight into how recovery of consciousness could be facilitated in anesthetized patients.

PI_NAMEs: HUANG, ZIRUI ;HUDETZ, ANTHONY GEORGE (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TITLE: Neuroimaging of Anesthetic Modulation of Human Consciousness

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Cardiovascular;Machine Learning and Artificial Intelligence;Precision Medicine;Wound Healing and Care

ORG_CITY: CHAPEL HILL

ORG_DEPT: SURGERY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Chronic limb threatening ischemia (CLTI) is a condition with increasing prevalence in the United States that puts patients at a high risk for wounds, limb loss, and death. Treatment is complex, often evolving over time, and involves medications, wound care, and surgical or endovascular revascularization. The results of this study will yield a comprehensive staging system for CLTI by jointly estimating initial limb outcome and survival risk, and quantifying how those risks evolve over time as key treatments are administered.

PI_NAMEs: MCGINIGLE, KATHARINE L (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Address;Adult;Adverse event;Affect;Algorithms;Anatomy;artery occlusion;Assessment tool;Atherosclerosis;Blood flow;Blood Vessels;burden of illness;Bypass;Cardiac;Cardiovascular Diseases;Cardiovascular system;Caring;Cessation of life;Characteristics;Cholesterol;Chronic;Chronic Care;Classification;Clinical;cohort;comorbidity;Complex;Data;Diabetes Mellitus;Diagnosis;Disease;Disease Progression;End stage renal failure;Event;expectation;femoral artery;follow-up;foot;Freedom;Future;Goals;Health;high risk;Hypertension;improved;Individual;individualized medicine;Infection;Intervention;Ischemia;Knowledge;Life;life span;limb amputation;limb loss;Limb Salvage;Limb structure;Lower Extremity;Machine Learning;Measures;Medical;Modeling;mortality;mortality risk;National Heart, Lung, and Blood Institute;non-healing wounds;older adult;Operative Surgical Procedures;Outcome;Participant;Patient Care;patient response;Patient-Focused Outcomes;Patients;Pattern;people of color;Perioperative;Peripheral arterial disease;Persons;Pharmaceutical Preparations;Phenotype;precision medicine;precision medicine clinical trials;preservation;Prevalence;Process;Randomized, Controlled Trials;Recommendation;Recurrent disease;Reporting;Research;Research Support;revascularization;Risk;Risk Assessment;Saphenous Vein;secondary analysis;Sequential Multiple Assignment Randomized Trial;Smoke;Staging;Staging System;Strategic vision;success;survival outcome;System;Testing;Tibial Arteries;Time;tobacco abuse;tool;treatment pattern;Treatment Protocols;treatment response;United States;Update;Veins;Woman;Work;wound;wound care;wound treatment

PROJECT_TITLE: Machine learning-based staging system to predict chronic limb-threatening ischemia disease progression and survival: A secondary analysis of the BEST-CLI trial data

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Human Genome;Liver Disease

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: PROJECT NARRATIVE One of the major complications of hypercholesterolemia is atherosclerosis, which is the leading cause of death in the US. Using a panel of diverse inbred mouse strains, we have recently uncovered a novel sex-specific role for a liver gene, L-PK, in regulating mitochondrial functions and liver triglyceride accumulation, while also suggesting a possible role in regulating plasma cholesterol levels. This R01 proposal aims to address a major public health problem and will define the sex-specific mechanisms by which L-PK regulates cholesterol metabolism and its implications with regards to atherosclerosis progression using state-of-the-art experimental approaches and a team of experts.

PI_NAMEs: CHELLA KRISHNAN, KARTHICKEYAN  (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Acceleration;Address;Affect;Anabolism;Androgen Receptor;androgen sensitive;Androgens;Animal Model;Appearance;Area;Atherosclerosis;Binding;Bioenergetics;Biological Assay;Candidate Disease Gene;Carbon;Cardiometabolic Disease;causal variant;Cause of Death;CETP gene;Cholesterol;cholesterol biosynthesis;Cholesterol Homeostasis;chromatin immunoprecipitation;citrate carrier;Citrates;clinical phenotype;cohort;Coronary Arteriosclerosis;Data;Development;Disease;Down-Regulation;Estradiol;Estrogens;experimental study;Failure;fast protein liquid chromatography;Fatty Liver;follow-up;gain of function;gene network;Gene Targeting;Genes;Genetic;Genetic Models;Genetic Transcription;Genetic Variation;genome wide association study;genome-wide;Genomic approach;genomic locus;Genomics;Grant;Heart Diseases;Hepatic;Hepatocyte;Heritability;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Human Genome;human induced pluripotent stem cells;Hybrids;Hydroxysteroids;hypercholesterolemia;Hyperlipidemia;improved;Inbred Strains Mice;inhibitor;insulin sensitivity;intrahepatic;knock-down;Label;LDL Cholesterol Lipoproteins;Lesion;lipidomics;Lipids;lipoprotein cholesterol;Lipoproteins;Literature;Liver;liver function;loss of function;Low-Density Lipoproteins;Luciferases;male;Measurement;Measures;Mediating;Metabolic Diseases;Metabolism;metabolomics;Mitochondria;Modeling;molecular phenotype;mouse model;multiple omics;Mus;non-alcoholic fatty liver disease;novel;Nutrient;Organoids;overexpression;Oxidoreductase;Pathway interactions;personalized therapeutic;phenomics;Phenotype;PIK3CG gene;Plasma;preference;Process;Production;programs;Promoter Regions;Proteins;Proto-Oncogene Proteins c-akt;PTEN gene;Public Health;Pyruvate;pyruvate carrier;Pyruvate Kinase;Regulation;Reporting;reuptake;Risk Factors;RNA;Role;sex;Signal Pathway;Signal Transduction;Stanolone;Testing;Therapeutic Effect;therapeutic target;transcriptome;transcriptomics;Translating;Triglycerides;uptake;Validation;Very low density lipoprotein;Water;Western Blotting;western diet

PROJECT_TITLE: Sex-Specific Roles of L-PK in Cholesterol Metabolism and Atherosclerosis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Project Narrative This research investigates the pharmacological mechanisms underlying the efficacy and resistance of lenalidomide, a molecular glue degrader for the treatment of multiple myeloma. Furthermore, this study proposes an innovative approach for identifying novel molecular glues. By enhancing our comprehension of molecular glue activities, and offering a pathway to discover novel molecular glue compounds, this research has the potential to broaden the scope of druggable proteins and facilitate the development of novel therapies for presently untreatable cancers.

PI_NAMEs: YOON, HOJONG  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;anti-cancer;Antineoplastic Agents;Area;BCL6 gene;Biochemical;Biological;Biological Assay;Biology;Cancer Biology;career development;Chemicals;chemoproteomics;Clinic;Clinical;Clinical Trials;Complex;Comprehension;CRISPR-mediated transcriptional activation;Data;Data Analyses;data visualization;Development;Development Plans;drug discovery;drug efficacy;Drug resistance;Energy Transfer;FDA approved;Fluorescence;Glues;Goals;Human;improved;Influentials;innovation;insight;Institution;interest;Investigation;Investigational Drugs;Lead;lenalidomide;Libraries;Malignant Neoplasms;Mass Spectrum Analysis;Mentors;Methodology;Methods;Modality;Molecular;multiple drug use;Multiple Myeloma;Nature;novel;novel therapeutics;Oncogenic;Outcome;Pathway interactions;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;Phenotype;Play;polymerization;Polymers;Polyubiquitination;Positioning Attribute;pre-clinical;Process;Program Development;programs;protein degradation;Protein Degradation Induction;protein protein interaction;Proteins;Proteome;receptor;recruit;Reporter;Reporting;Research;Research Personnel;Resistance;RNA Splicing;Role;screening;skills;small molecule;success;System;targeted cancer therapy;Testing;Therapeutic;Time;Training;Training Programs;transcription factor;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: A Chemoproteomic Approach to Identify Molecular Glues for Targeted Cancer Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (O1)]


NIH_SPENDING_CATS: Diabetes;Digestive Diseases;Liver Disease;Maternal Health;Nutrition;Pediatric;Pregnancy;Women's Health Research

PHR: PROJECT NARRATIVE The role of placental hormones in securing metabolic homeostasis in the mother and fetus during pregnancy is poorly understood; and the potential role of placental hormones and other placental products in maintaining maternal health and treating metabolic disorders outside of pregnancy is insufficiently explored. The present proposal aims to understand the effects of the placental hormone kisspeptin in regulating liver metabolism as well as blood glucose homeostasis. The studies will also elucidate kisspeptin-activated signaling mechanisms in liver cells with the potential to identify novel targets for treating metabolic disorders.

PI_NAMEs: HUSSAIN, MEHBOOB A (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Acceleration;Acute;Address;Adenosine Monophosphate;Adipose tissue;Appearance;autocrine;Blood Glucose;blood glucose regulation;Cell Line;Child;Coupled;Diabetes Mellitus;Diet;diet-induced obesity;Ensure;Exhibits;Exposure to;Fasting;fatty acid oxidation;fatty liver disease;Female;fetal;Fetus;G alpha q Protein;G-Protein-Coupled Receptors;Glucagon;Gluconeogenesis;Glucose;glucose output;Health;Hepatic;Hepatocyte;Homeostasis;Hormones;Human;Hypoglycemia;impaired glucose tolerance;In Vitro;in vivo;Inositol;insight;Insulin;Insulin Resistance;ITPR1 gene;ketogenesis;Ketosis;KISS1 gene;Lipids;Lipolysis;Liver;Liver diseases;liver metabolism;Maternal Health;Mediating;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;Molecular;mortality risk;Mothers;mouse model;Mus;Muscle;novel;Nutrient;Nutritional;Obesity;Output;Pancreas;Pancreatic Hormones;paracrine;Pathway interactions;Phosphotransferases;Physiological;Placenta;Placental Hormones;Pregnancy;pregnant;Production;programs;receptor;Receptor Signaling;Recovery;Regulation;Risk;Role;Secure;Shapes;Signal Pathway;Signal Transduction;Starvation;Testing;therapeutic target;Third Pregnancy Trimester;tripolyphosphate

PROJECT_TITLE: The Role of Kisspeptin in Metabolism Regulation

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: Project Narrative The proposed research will help elucidate how the tumor suppressor BRCA1-BARD1 antagonizes the DNA damage response protein 53BP1 to promote DNA double-strand break repair by homologous recombination (HR) post-replication. This work is relevant to public health because by revealing the mechanisms of action of BRCA1-BARD1, it will help identify in patients BRCA1-BARD1 mutations that inactivate HR and may be causative for cancer, especially breast and ovarian cancer. Furthermore, because several anti-cancer drugs target HR-deficient cancer cells, in the long term the new knowledge gained on BRCA1-BARD1-mediated HR DNA repair could help develop new means of inactivating HR and counteracting drug resistance that patients with cancer often acquire over time.

PI_NAMEs: MER, GEORGES  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Antineoplastic Agents;BARD1 gene;Binding;Biochemistry;BRCA1 gene;C-terminal;cancer cell;cancer prevention;Cell Cycle;Cell Physiology;Cells;Cellular biology;Chromatin;Chromosomal Rearrangement;combat;Data;Dependence;Development;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Repair;Double Strand Break Repair;Drug resistance;Drug Targeting;Embryo;Eukaryotic Cell;Excision;G1 Phase;G2 Phase;genome integrity;Goals;Hereditary Breast and Ovarian Cancer Syndrome;Histone H2A;Histone H4;Histones;homologous recombination;homologous recombination deficiency;In Vitro;Ionizing radiation;Knowledge;Ligase;Link;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Molecular;Mus;Mutate;Mutation;N-terminal;Nonhomologous DNA End Joining;novel therapeutic intervention;novel therapeutics;Nucleoplasm;Nucleosome Core Particle;Nucleosomes;Outcome;p53-binding protein 1;Pathway interactions;Patients;Phosphorylation;Play;Positioning Attribute;Post-Translational Protein Processing;prevent;Process;Proteins;Public Health;recruit;repaired;Research;response;S phase;Solid;structural biology;Structure;Tail;Testing;Time;tumor;Tumor Suppressor Proteins;tumorigenesis;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Variant;Work

PROJECT_TITLE: Post-translational Modifications in DNA Damage Response: a Structural Perspective

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: TAMPA

ORG_NAME: JAMES A. HALEY VA MEDICAL CENTER

PHR: Serum amyloid A (SAA) proteins are critical to the regulation of inflammation in systemic as well as neurological diseases. Studies have shown that during an acute phase response (APR), SAA levels increase 1000-fold and can stimulate the inflammasome, trigger the recruitment of immune cells to inflammatory sites, and elicit the induction of enzymes that degrade extracellular matrix. SAA levels are significantly elevated following stroke/cerebral ischemia linking systemic inflammation and neurological disorders.

PI_NAMEs: KINDY, MARK S. (contact)

PROJECT_TERMS: Acute-Phase Reaction;Antibodies;attenuation;Biological Markers;Brain;Cathepsins B;Cell Culture Techniques;Cells;Cerebral Ischemia;Cessation of life;Clinical Management;Deposition;Enzyme Induction;Event;experimental study;Extracellular Matrix;Generations;Goals;High Density Lipoproteins;Human;Immune;Infarction;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Intervention;Laboratories;Link;Mediating;Microglia;Molecular;mouse model;Mus;Nervous System Disorder;neuron loss;Neuronal Injury;Outcome;Pathogenesis;Pathology;Plasma;recruit;Regulation;Role;Serum amyloid A protein;Signal Transduction;Site;small molecule;Stroke;stroke outcome;systemic inflammatory response;targeted treatment;Testing;Therapeutic Intervention;Tissues;Transgenes;Viral Vector

PROJECT_TITLE: Role of Serum Amyloid A in the Pathogenesis of Stroke

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURC-H (01)]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Project Narrative Multiple sclerosis (MS) is the most common neuroinflammatory disease among young adults. The overall goal of this proposal is to identify the signaling pathways and their effector mediators that regulate the interactions of pathogenic CD4+ T cells and antigen-presenting cells within the central nervous system that exacerbate neuroinflammation. Targeting these pathways and mediators may become a novel strategy for the treatments of MS.

PI_NAMEs: WAN, EDWIN CHI KEUNG (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Active Immunization;Adoptive Transfer;Affinity;Animal Model;Antibodies;Antigen-Presenting Cells;Autoimmune;axonal degeneration;Biological Assay;Biological Process;CCL17 gene;CD4 Positive T Lymphocytes;Cell Communication;Cell Separation;cell type;Cells;Central Nervous System;chemokine;Complex;cytokine;Cytokine Activation;Demyelinations;Dendritic Cells;dimer;Disease;early onset;effective therapy;Experimental Autoimmune Encephalomyelitis;Extravasation;Fluorescence Microscopy;Freund's Adjuvant;Gene Expression Profile;Genetic Models;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Growth Factor;IL17 gene;Imaging Techniques;Immune;In Vitro;in vivo;Infiltration;Inflammation;insight;Integrin alpha4beta1;Integrin Binding;Integrins;Interferon Type II;Interferons;intravital imaging;ITGAX gene;Knock-in;Knock-in Mouse;Macrophage;Mediating;Mediator;Meningeal;Meninges;Monitor;monocyte;Mouse Strains;Multiple Sclerosis;multiple sclerosis treatment;Mus;Myeloid Cells;N Domain;neuroinflammation;novel;novel strategies;Onset of illness;Other Genetics;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Phenotype;Play;Population;Recombinants;Reporter;Reporting;response;Role;Signal Pathway;Signal Transduction;Spinal Cord;Stat5 protein;STAT5B gene;T cell infiltration;Testing;Work;young adult

PROJECT_TITLE: STAT5 Tetramerization in Autoimmune-mediated Neuroinflammation

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health because it has significant promise to impact implementation strategies to increase human papillomavirus (HPV) vaccination and other health contexts where provider communication and reminder messages are important (e.g., cancer screenings and shared decision making about cancer treatments). The project maximizes the impact of the Text & Talk study by extending the findings with additional data to understand the factors related to for whom and why the implementation strategies were effective and sustainable. The proposed research is relevant to NIH’s mission to prevent cancer and eliminate disparities in cancer within the United States.

PI_NAMEs: STARAS, STEPHANIE A S (contact)

PROGRAM_OFFICER_NAME: KOBRIN, SARAH

PROJECT_TERMS: 12 year old;15 year old;Address;Adolescent;Age;arm;Behavior;Behavioral;boys;cancer diagnosis;cancer health disparity;cancer prevention;cancer therapy;Censuses;Child;Child Rearing;Clinic;Clinic Visits;Clinical effectiveness;clinical practice;Clinical Research;Consolidated Framework for Implementation Research;Counseling;Data;Data Collection;design;Development;disparity elimination;Dose;Educational Materials;Effectiveness;effectiveness evaluation;Empathy;Equity;evidence base;experience;Florida;Future;geographic disparity;girls;Goals;Health;health equity;health organization;Health Personnel;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;implementation strategy;improved;Incentives;Individual;innovation;Intervention;Interview;Learning;Link;live text;Measures;Methods;Mission;Modeling;Neighborhoods;parent project;Parents;patient oriented;Planning Theory;practice factors;pragmatic trial;prevent;primary care clinic;Provider;provider behavior;provider communication;Public Health;Randomized;Recommendation;recruit;Reporting;Research;Resources;Risk;Schedule;Screening for cancer;shared decision making;social cognitive theory;social health determinants;social vulnerability;Structure;Sum;Surveys;synergism;Testing;Text;Text Messaging;text messaging intervention;theories;Training;United States;United States National Institutes of Health;Vaccinated;vaccine efficacy;vaccine safety;Vaccines

PROJECT_TITLE: Text and Talk: A multi-level intervention to increase provider HPV vaccine recommendation effectiveness


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Prostate Cancer;Social Determinants of Health;Urologic Diseases

ORG_CITY: EAST LANSING

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Cancer is the second leading cause of death in the U.S., and less than 1 in 4 new cancers are estimated to be detected by screening, although screening improves outcomes. HFH-MSU will establish a cancer screening research recruitment hub that engages diverse participants and will conduct real-world clinical trials to advance cancer screening in the U.S.

PI_NAMEs: NESLUND-DUDAS, CHRISTINE MARIE (contact);SIMOFF, MICHAEL

PROGRAM_OFFICER_NAME: LEEVAN, ELYSE MICHELLE

PROJECT_TERMS: Accreditation;Advanced Malignant Neoplasm;Ambulatory Care Facilities;Basic Science;Biological;Biological Assay;Black race;Blood Tests;Brain;Breast;Breast Cancer Detection;Cancer Detection;cancer diagnosis;Cancer Patient;cancer prevention;cancer risk;cancer site;Caring;Catchment Area;Cause of Death;cell free DNA;Cessation of life;Cities;Clinic;Clinical;clinical practice;Clinical Sciences;Clinical Trials;Clinics and Hospitals;Cohort Studies;Colorectal;Colorectal Cancer;Communication;Community Health Services;Community Healthcare;cost;Data;Data Collection;Data Coordinating Center;data management;design;detection assay;detection test;Development;Diagnosis;Disparity;Effectiveness;Electronic Health Record;Enrollment;Epidemiology;Ethnic Origin;experience;Faculty;follow-up;frontier;Funding;Future;Goals;Head and neck structure;Health;Health Sciences;Health Services Research;Hospitals;improved;improved outcome;Industry;Infrastructure;Integrated Delivery of Health Care;Integrated Health Care Systems;Location;Lung;Lymphoma;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;Methods;metropolitan;Michigan;Minority Groups;mortality;multidisciplinary;multiple omics;National Cancer Institute;neoplasm registry;Network Infrastructure;novel;Outcome;Outcome Measure;Ovarian;Participant;Pathology;patient engagement;patient oriented;Patient Outcomes Assessments;Patients;Persons;Physicians;Pilot Projects;Population Research;Population Sciences;Populations at Risk;Pragmatic clinical trial;prevention clinical trial;Process;programs;Prostate;Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial;protein biomarkers;Public Health;Publishing;Qualifying;Race;Racial Segregation;Radiology Specialty;randomized trial;recruit;Research;Research Personnel;Resources;screening;Screening for cancer;screening guidelines;Services;Site;Social Work;socioeconomic disadvantage;socioeconomics;Stage at Diagnosis;statistics;suburb;System;Technology;Testing;United States;United States National Institutes of Health;United States Preventative Services Task Force;Universities;Urban Population;Validation;Work

PROJECT_TITLE: HFH-MSU CSRN ACCrual Enrollment and Screening Site

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (O1)]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: The proposed research is highly relevant to public health, as it investigates the connection between a neurexin1-mediated core synaptic pathway and the heparan sulfate-mediated pathway, which have both been implicated in autism, schizophrenia, and intellectual disability. Our proposed studies aim to link two pathways and shed light on the biological significance of the heparan sulfate attachment to neurexin1 in vivo, as well as uncover the underlying molecular mechanism. By doing so, we hope to unravel a unified mechanistic understanding of the synaptic abnormalities in these diseases.

PI_NAMEs: ZHANG, PENG  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Affect;AMPA Receptors;autism spectrum disorder;Binding;Biological;Biology;Brain;brain tissue;Categories;Cells;Complex;Data;Dedications;Development;Disease;DLG4 gene;Doctor of Philosophy;Education;Enzymes;Gonadal Steroid Hormones;Growth Factor;Heparan Sulfate Biosynthesis;Heparitin Sulfate;Hippocampus;Impairment;in vivo;Individual;innovation;insight;Intellectual functioning disability;Laminin;Link;Mediating;Microscopy;Modification;Molecular;Mus;mutant;Mutant Strains Mice;Mutation;N-Methyl-D-Aspartate Receptors;Neurons;novel;novel therapeutic intervention;Outcome;Pathway interactions;pleiotrophin;Polysaccharides;Post-Translational Protein Processing;Postdoctoral Fellow;postsynaptic;presynaptic;Presynaptic Terminals;Protein Isoforms;Proteins;Public Health;Qualifying;Receptor Activation;recruit;Research;Role;Schizophrenia;Synapses;synaptic function;Synaptic Membranes;Testing;Training;Variant;Vertebral column;Viral;Visualization;voltage clamp;Work

PROJECT_TITLE: The role of heparan sulfate modification on neurexin1 in synapse development

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ORG_CITY: GREENVILLE

ORG_NAME: EAST CAROLINA UNIVERSITY

PHR: PROJECT NARRATIVE Although colorectal cancer (CRC) is enriched with pathogenic mtDNA mutations, the role of the mitochondrion in CRC remains unknown. In this proposal, we will leverage our expertise in mitochondrial biochemistry, state- of-the art in vivo, in vitro, and ex vivo CRC models, and viral genetic manipulation to define the molecular pathways linking mitochondrial metabolism to CRC growth. By providing a mechanistic link between mitochondrial bioenergetics and CRC, this work will move the field forward in our understanding of the role of mitochondria in CRC, ultimately paving the way for CRC-specific mitochondrial interventions.

PI_NAMEs: FISHER-WELLMAN, KELSEY H (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Acceleration;alternative oxidase;Anabolism;antiporter;Aspartate;ATP Synthesis Pathway;Biochemistry;Bioenergetics;burden of illness;cancer cell;cancer initiation;Cancer Model;catalase;Catalytic Domain;Cell Proliferation;Cell Respiration;Chemicals;Clinical;Colon;Colorectal Cancer;Complex;Cytochrome c Reductase;Cytosol;Data;Data Set;Electron Transport;Exhibits;experimental study;Exposure to;Gene Deletion;Generations;Genes;Genetic;genetic approach;genetic manipulation;Genetically Engineered Mouse;Glutamates;Goals;Growth;Homeostasis;Human;human model;Impairment;In Vitro;in vivo;Incidence;inhibitor;insight;Intervention;Knockout Mice;Large-Scale Sequencing;Link;loss of function;loss of function mutation;Malignant Neoplasms;Mediating;Metabolic;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial metabolism;Molecular;mouse model;Mus;Mutate;NADH;Normal tissue morphology;Organoids;oxidation;Oxidation-Reduction;Pathogenesis;Pathogenicity;Pathway interactions;pharmacologic;Proteins;Proteome;Reactive Oxygen Species;Respiration;respiratory;Respiratory physiology;response;Role;Stress;Testing;Therapeutic;Tissues;transgene expression;tumor;tumor growth;Tumor-Derived;tumorigenesis;tumorigenic;virus genetics;Work;Xenograft procedure;Yeasts

PROJECT_TITLE: Mitochondrial bioenergetics and colorectal cancer

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]