ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE Immunotherapy is one of the most important new approaches to cancer therapy to emerge over the last several decades but is associated with unique side effects that often mimic immune diseases. Recent studies have identified thrombosis (excessive blood clotting) as an important side effect of immunotherapy, however, nothing is known about the underlying causes of blood clots in these patients. The goal of this application is to define these mechanisms using patient samples and a mouse model of blood clots induced by immunotherapy.

PI_NAMEs: DIAZ-MONTERO, CLAUDIA MARCELA;KHORANA, ALOK A;MCCRAE, KEITH R. (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Address;Agonist;Animal Model;anti-PD1 antibodies;antithrombin III-protease complex;Blood;Blood coagulation;Blood Platelets;Blood Vessels;Body mass index;cancer cell;cancer diagnosis;cancer immunotherapy;Cancer Patient;cancer risk;cancer therapy;cancer type;Cell model;Cell Separation;cell type;Cells;checkpoint therapy;Chemotherapy and/or radiation;Clinical;clinically relevant;Coagulation Process;cohort;Complication;CTLA4 gene;cytokine;Development;Disabling;Disease;Endothelial Cells;Endothelium;extracellular;extracellular vesicles;Fibrin fragment D;forging;Frequencies;Gene Expression;Generations;genetic regulatory protein;Goals;Hemoglobin;high risk;Histone H3;Human;IL8 gene;Immune;Immune checkpoint inhibitor;Immune System Diseases;immune-related adverse events;Immunoglobulin G;Immunologic Surveillance;Immunophenotyping;immunoregulation;Immunotherapy;In Vitro;Incidence;Incubated;Inflammation;Inflammatory;inflammatory marker;Interferon Type II;Knowledge;Laboratory Study;Leukocytes;Malignant Neoplasms;Measures;Mediating;Modeling;Monoclonal Antibodies;monocyte;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;Myelogenous;Myeloid Cells;neoplastic cell;neutrophil;Newly Diagnosed;novel strategies;Pathogenesis;Pathway interactions;patient stratification;Patients;peripheral blood;Plasma;Platelet Activation;Platelet aggregation;Platelet Count measurement;Population;potential biomarker;Prevention approach;programmed cell death ligand 1;programmed cell death protein 1;prospective;Prothrombin;Publishing;Reporting;response;Risk;Risk Assessment;Role;Sampling;side effect;Source;System;T-Lymphocyte;Thrombin;thromboinflammation;Thromboplastin;Thrombosis;Thrombus;tumor;Tumor Immunity;Vascular Cell Adhesion Molecule-1;venous thromboembolism;Venous Thrombosis;White Blood Cell Count procedure

PROJECT_TITLE: Mechanisms of cancer immunotherapy-associated thrombosis

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Physical Injury - Accidents and Adverse Effects

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ORTHOPEDICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Tendons can withstand large forces due to a highly aligned, dense collagen matrix. The overall objective is to delineate mechanisms by which the temporal expression of Col3 modulates the injury response throughout tendon healing, as well as its differential effect throughout aging. We will test the hypothesis that Col3 is crucial for early tendon healing, but that its continued expression during remodeling is detrimental.

PI_NAMEs: SOSLOWSKY, LOUIS J (contact);VOLK, SUSAN W

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Age;age effect;aged;Aging;animal old age;Architecture;Biocompatible Materials;Biological Assay;Biomimetics;bone;Cells;Cellular Infiltration;Cellularity;Cicatrix;clinically relevant;Collagen;Collagen Type I;Collagen Type III;Coupled;crosslink;density;Deposition;disability;Dose;Fiber;Fibroblasts;healing;Immune;Impairment;improved;improved outcome;Inferior;Infiltration;Inflammation;Injury;innovation;insight;Integrins;knock-down;Knowledge;Mechanics;middle age;migration;Minor;mouse model;Myofibroblast;neovascularization;novel;old mice;Pain;Patients;Peptides;Phase;Population;pre-clinical;Predisposition;progenitor;recruit;Regulation;repaired;Resolution;response;response to injury;Role;scaffold;Skin;skin wound;Small Interfering RNA;Structure;Tendon Injuries;Tendon structure;Testing;Therapeutic;Time;Tissues;wound healing

PROJECT_TITLE: Collagen III differential roles in temporal regulation of tendon healing across ages

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: GM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE Tissue repair requires coordinated protein presentation that is difficult to achieve with current biomaterial delivery vehicles. Using an innovative approach involving directed evolution and rational protein design, we will engineer a library of novel affinity-based biomaterials to investigate the effects of protein delivery and sequestration on tissue regeneration. This work will uncover new insights into the overarching roles of many proteins that govern tissue repair, which will be critical in tailoring biomaterials to treat different types of injuries.

PI_NAMEs: HETTIARATCHI, MARIAN HIRUSHIKA (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Affect;Affinity;Area;Binding;Biocompatible Materials;Bone Injury;Complex;Computer Models;delivery vehicle;design;Development;Directed Molecular Evolution;Engineering;flexibility;healing;Implant;improved;injured;Injury;innovation;insight;interest;Knowledge;Libraries;Modeling;novel;Outcome;Process;protein complex;Protein Engineering;Protein Inhibition;Proteins;receptor;receptor binding;regenerative;Regenerative Medicine;response;Role;Signaling Protein;Site;Societies;spatiotemporal;Specificity;Surface;Tertiary Protein Structure;Testing;tissue regeneration;tissue repair;Tissues;tool;Work;wound healing;Yeasts

PROJECT_TITLE: Modulating Protein Activity in Tissue Repair using Engineered Affinity-based Biomaterials


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: WORCESTER

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE The goal of this Training Program is to recruit talented, well-trained, and well-motivated predoctoral investigators and provide them with highly skilled and collaborative mentors from multiple disciplines to give them optimal preparation for competitive careers in academic research and industry in the areas of immunology and microbiology.

PI_NAMEs: STERN, LAWRENCE J. (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Immunology;Microbiology;Training

PROJECT_TITLE: Training in Immunology and Microbiology

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Neurosciences;Opioids

ORG_CITY: CORAL GABLES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative The proposed research is relevant to public health because T2D is a life-threatening disease. Upon conclusion of these studies, we will establish that insulin secretion is regulated by a novel β- to δ-cell dynorphin/Kappa opioid receptor negative feedback loop, and this feedback loop contributes to hyperglycemia in diabetes. These discoveries will stimulate the opening of a new avenue for the design of novel strategies using the dynorphin/Kappa opioid receptor axis as a therapeutic target for the treatment of diabetes.

PI_NAMEs: BLANDINO-ROSANO, MANUEL  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: addiction;Beta Cell;Binding;biological adaptation to stress;blood glucose regulation;Cell Communication;cell injury;Cell Physiology;Cell secretion;Cells;Communication;D Cells;Data;design;diabetes management;Diabetes Mellitus;diabetogenic;Disease;Dynorphins;endogenous opioids;Epidemic;experimental study;Exposure to;Family;Feedback;gamma-Aminobutyric Acid;Genes;Genetic;Glucagon;Glucose;glucose metabolism;Goals;High Fat Diet;Hormonal;Hormone secretion;Hormones;Human;Hyperglycemia;Impairment;improved;In Vitro;in vivo;Incubated;innovation;Insulin;insulin granule;Insulin Resistance;insulin secretion;islet;Islet Cell;Islets of Langerhans;kappa opioid receptors;Knowledge;Life;Messenger RNA;Modeling;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Opioid Antagonist;Opioid Peptide;Opioid Receptor;Outcome;overexpression;Pain;paracrine;Paracrine Communication;Pathologic;pharmacologic;Phenotype;Physiological;Physiology;programs;Public Health;Publishing;Regulation;Research;response;Role;Signal Transduction;Somatostatin;System;Testing;Therapeutic;therapeutic target;urocortin;Work

PROJECT_TITLE: Dynorphin, a novel paracrine factor that regulates insulin secretion

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Inflammation is exquisitely linked to the pathogenesis of immune-mediated conditions. Nanoparticles have risen as a novel strategy to manipulate immune cell responses through multiple biochemical pathways and non-specific and antigen-specific mechanisms. The central vision of my research program is to systematically evaluate the cellular and molecular mechanisms affected by nanoparticles in the context of sepsis (non- specific) and autoimmunity (antigen-specific) to develop fundamental and functional relationships between their physicochemical properties and generated immune responses to ultimately guide the future development of novel therapeutics.

PI_NAMEs: PEARSON, RYAN MATTHEW (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;Affect;Agonist;Allergic;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Area;Autoimmune;Autoimmunity;Biochemical Pathway;Biological;CD27 Antigens;Celiac Disease;Cells;chemical property;clinical implementation;clinical translation;Clinical Treatment;Clinical Trials;clinically relevant;Custom;design;Development;Disease;Disease Progression;Encapsulated;Endotoxemia;Formulation;Future;Goals;Homeostasis;Host Defense Mechanism;human disease;Hypersensitivity;Immune;immune activation;Immune response;Immune system;Immune System Diseases;immunoengineering;Immunology;immunoregulation;improved;In Vitro;in vivo Model;Inflammation;Inflammatory;Inflammatory Response;Intervention;Link;Maintenance;Mediating;microbial;Molecular;mouse model;nanoassembly;nanoparticle;nanopolymer;novel;novel strategies;novel therapeutics;Outcome;Outcome Study;Pathogenesis;Peptides;Phase;physical property;Polymers;programs;Property;Proteins;Research;response;Sepsis;success;Therapeutic;Therapeutic Agents;Tissues;Toll-like receptors;translational applications;Vision

PROJECT_TITLE: Polymeric nanoassemblies for precise tuning of immune responses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Lung;Pulmonary Fibrosis;Rare Diseases

ORG_STATE: OH

PHR: Narrative Idiopathic pulmonary fibrosis is a scarring disorder of the lung that has no medical cure. We propose to study how the cells that form the scar are generated in an attempt to identify new targets for treatment. Specifically, we will study how a protein that senses stiffness interacts with another key protein to generate scar forming cells in the lung.

PI_NAMEs: OLMAN, MITCHELL ALAN (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Affect;Amino Acids;antifibrotic treatment;Automobile Driving;Binding;Biochemical;Cations;Cell membrane;Cells;chemokine;Cicatrix;clinically relevant;Complex;Cytoskeleton;Data;Databases;design;Development;Disease;Effector Cell;Experimental Designs;Experimental Models;Extracellular Matrix;Family;Fibroblasts;Fibrosis;fibrotic lung;gain of function;Generations;Genetic;Genomics;Goals;Human;human disease;idiopathic pulmonary fibrosis;in silico;In Vitro;in vivo;in vivo Model;inhibitor;Integrins;Knowledge;Lentivirus;Link;loss of function;Lung;Lung Diseases;mechanical properties;mechanical signal;Mediating;Medical;Microtubules;Modeling;Molecular;mouse model;Mus;Mutate;Myofibroblast;Nature;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathway interactions;Patients;Persons;Phase;phosphatidylinositol 3-kinase gamma;Phosphotransferases;PIK3CG gene;profibrotic cytokine;protein complex;protein purification;Protein translocation;protein transport;Proteins;Publishing;Pulmonary Fibrosis;receptor;response;Role;Scaffolding Protein;Signal Transduction;Site;small molecule;Stretching;Structure of parenchyma of lung;System;Testing;Tissues;Transforming Growth Factor beta;Translating;TRPV channel;Vanilloid

PROJECT_TITLE: Profibrotic Mechanisms of the TRPV4-PI3K-gamma Protein Complex

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention;Sexually Transmitted Infections

ORG_CITY: Aurora

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Alzheimer's disease affects 1 in 9 Americans over 65 years of age, is the 6th leading cause of death, and costs $355 billion annually. Herein, we aim to understand how viruses interact with an aging olfactory system to accelerate Alzheimer's disease. This proposal will identify potential biomarkers and therapies (e.g. vaccines and antiviral agents) that may slow or halt progression to clinical dementia, disability, and death.

PI_NAMEs: NAGEL, MARIA ACENA;RESTREPO, DIEGO  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Acceleration;Affect;Age;Age Years;aged;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;American;Amyloid;Amyloid beta-Protein Precursor;Amyloid deposition;Anosmia;Anti-viral Agents;Antibodies;Apoptosis;Behavioral;Biological;Biological Assay;Biopsy;Calcium;Cause of Death;cell type;Cells;Cerebrospinal Fluid;Cessation of life;chronic infection;Clinical;Cognitive;cognitive change;cohort;comparison control;cost;Coupled;cytokine;Data;Dementia;dementia risk;disability;Disease;disease phenotype;Disease Progression;Electron Microscopy;entorhinal cortex;Enzyme-Linked Immunosorbent Assay;familial Alzheimer disease;Formalin;Frequencies;Functional disorder;Gene Expression;Genes;Genetic Transcription;Genotype;Herpesvirus 1;Herpesvirus Type 3;Hippocampus;Human;human old age (65+);Image;imaging system;Immunohistochemistry;Impaired cognition;Individual;Infection;Inflammatory;interest;islet amyloid polypeptide;liquid crystal polymer;Liquid substance;Literature;Macrophage;Mass Spectrum Analysis;Measures;Microglia;Mus;nano-string;Nasal cavity;Nerve Degeneration;neural;Neurites;neurogenesis;neuroinflammation;Neuronal Differentiation;Neuronal Dysfunction;olfactory bulb;Olfactory dysfunction;Olfactory Epithelium;Olfactory Pathways;olfactory sensory neurons;Olfactory tract;optogenetics;overexpression;Paraffin;Pathologic Processes;Pathology;Pathway interactions;Peptides;potential biomarker;prevent;Production;Proteins;Proteome;Proteomics;Risk Factors;RNA;Saliva;Sensory;Serum;Slide;Small Interfering RNA;Smell Perception;Statistical Data Interpretation;Testing;Time;Tissues;Transcript;transcriptome;transcriptomics;Transfection;treatment risk;Up-Regulation;Vaccines;varicella-zoster virus immediate early protein 62;Viral;viral DNA;Virus;Virus Diseases

PROJECT_TITLE: Virus and olfactory system interactions accelerate Alzheimer's disease pathology

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: TUCSON

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Malaria is the most important mosquito-borne disease of humans, but current mosquito control strategies and drug treatments in humans are becoming less effective as insecticide and drug resistance increases. Malaria parasites must acquire essential nutrients, including pantothenate or vitamin B5, from their mosquito and human hosts to successfully complete development. We will suppress mosquito pantothenate stores through a combination of small molecule treatments and genetic manipulations to starve malaria parasites of this essential nutrient to support future, novel mosquito-targeted malaria control strategies.

PI_NAMEs: LUCKHART, SHIRLEY ;RIEHLE, MICHAEL ALLEN (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Acetyl Coenzyme A;Affect;Anabolism;analog;Anopheles Genus;Binding;biological adaptation to stress;biological systems;Biology;Blood;Chemicals;Coenzyme A;cofactor;CRISPR/Cas technology;Culicidae;Daphnia;Data;Development;Drosophila genus;drug modification;Drug resistance;Engineering;Enzymes;Exhibits;fitness;Future;Generations;Genetic;genetic manipulation;Goals;Growth;Homology Modeling;Human;human disease;humanized mouse;In Vitro;Infection;Inherited;Insecta;Insecticide Resistance;insight;kinase inhibitor;knock-down;Lead;Libraries;life history;life span;Malaria;Metabolism;Midgut;Molecular;Mosquito Control;Mosquito-borne infectious disease;mouse model;novel;novel strategies;novel therapeutics;Nutrient;Nutritional Requirements;Oocysts;overexpression;Pantothenate kinase;Pantothenic Acid;Parasite resistance;Parasitemia;Parasites;Parasitic infection;Pathway interactions;Pediatric Hospitals;Pharmaceutical Preparations;Pharmacotherapy;Phosphoric Monoester Hydrolases;Plasmodium;Plasmodium falciparum;Plasmodium yoelii;prevent;Protein Kinase;PTEN gene;Reproduction;Resistance;Resistance development;resistant Plasmodium falciparum;Resources;RNA Interference;Saint Jude Children's Research Hospital;screening;Signal Transduction;small molecule;Specificity;Starvation;Stress;success;Testing;tool;trait;Transgenic Organisms;uptake;Validation;vector mosquito;Vectorial capacity;Vitamins;Work

PROJECT_TITLE: How to starve a parasite: Manipulating CoA biosynthesis to control Plasmodium development in the mosquito

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Lung;Pulmonary Hypertension;Rare Diseases

PHR: Project Narrative The proposed research by Dr. Zhiyu Dai is aimed at understanding why some patients develop high blood pressure in the lungs (pulmonary arterial hypertension). Pulmonary arterial hypertension is a serious and progressive disease with no cure and with 5-year mortality as great as 50%. In particular, we are trying to identify what factors are responsible for pulmonary arterial hypertension and develop a new effective therapeutic strategy for the treatment of this devastating disease.

PI_NAMEs: DAI, ZHIYU  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Animal Model;Apoptosis;Attenuated;Biological Assay;Blood capillaries;Blood Vessels;Cessation of life;Clinical;Data;Disease;Distal;effective therapy;Endothelial Cells;endothelial dysfunction;Endothelium;Exhibits;extracellular;FABP5 gene;Failure;fatty acid metabolism;fatty acid oxidation;fatty acid-binding proteins;Fatty Acids;Functional disorder;Generations;Genes;Genetic;Glycolysis;Glycolysis Induction;Goals;Heart Hypertrophy;Human;Hypertension;hypoxia-induced pulmonary hypertension;Injury;Lesion;Link;Lung;Mediating;Metabolic;Metabolism;metabolomics;Mitochondria;Modeling;Molecular;mortality;mouse model;Mus;Muscle;nanoparticle;new therapeutic target;novel;novel therapeutic intervention;overexpression;Palmitates;Palmitic Acids;Pathogenesis;Pathogenicity;Pathology;Patients;Phenotype;Plasma;Play;Population;premature;primary pulmonary hypertension;Progressive Disease;Proliferating;pulmonary arterial hypertension;Pulmonary Hypertension;pulmonary vascular remodeling;Pulmonary Vascular Resistance;Rattus;Reactive Oxygen Species;Reporting;Research;right ventricular failure;Role;Sampling;Signal Transduction;single-cell RNA sequencing;SOX17 gene;Specific qualifier value;Systolic Pressure;therapeutically effective;Transgenic Animals;treatment strategy;Up-Regulation;Vascular Diseases;Vascular remodeling;Ventricular

PROJECT_TITLE: Fatty acid-binding proteins sustain endothelial glycolysis and arterial programming in pulmonary arterial hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-H(03)]


ADMINISTERING_IC: PS

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STD AND TB PREVENTION

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative The prevention of HIV in the United States is in a transformational era. To understand men’s preferences for prevention products and strategies and what choices are being made by men with varying risk profiles, we will enroll a prospective cohort of 1275 of men who have sex with men (MSM) in Atlanta, Detroit and San Diego and follow the cohort for two years, with HIV and STI testing, quarterly quantitative assessments and qualitative assessments.

PI_NAMEs: SULLIVAN, PATRICK SEAN (contact)

PROJECT_TITLE: Understanding HIV/STD Risk and Enhancing PrEP Implementation Messaging in a Diverse Community-Based Sample of Gay, Bisexual, and Other Men Who Have Sex with Men in a Transformational Era


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative We will compile the first comprehensive evolutionary classification of the protein universe by categorizing millions of proteins with accurately predicted 3D structures, enabled by the recent breakthrough in protein modelling facilitated by Artificial Intelligence. Our classification will accelerate discovery and characterization of proteins involved in pathogenicity and human diseases by association of novel and uncharacterized proteins with their well-studied relatives and guide experimental studies.

PI_NAMEs: SCHAEFFER, RICHARD DUSTIN (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: 3-Dimensional;Acceleration;Adopted;Amino Acid Sequence;Artificial Intelligence;Base Sequence;Benchmarking;Biochemical;Biological;Biological Assay;candidate identification;caspase 14;Cataloging;Classification;Code;Collaborations;Communities;comparative genomics;computational pipelines;Computing Methodologies;Data;data quality;Data Set;Data Sources;database schema;Databases;Dedications;deep learning;Deposition;Development;Disease;Electron Microscopy;European;Evolution;experimental study;Family;Future;Genetic;Growth;Homologous Gene;Human;human disease;human pathogen;improved;Infrastructure;Laboratories;Lead;learning network;Manuals;Membrane;Methods;model organism;Modeling;Molecular Biology;NMR Spectroscopy;novel;pathogen;pathogenic bacteria;Pathogenicity;Pathogenicity Island;Peptide Signal Sequences;Periodicals;Property;protein data bank;Protein Family;protein function;protein structure;protein structure prediction;Proteins;Science;Sequence Homology;Site;structural biology;Structure;success;System;Techniques;Tertiary Protein Structure;Testing;three dimensional structure;Time;tool;Universities;Update;Vibrio;Virulence Factors;web interface;web page;web site;Work;Workload;X-Ray Crystallography

PROJECT_TITLE: ECOD: Large scale classification of predicted and experimental protein structures

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Regenerative Medicine

ORG_CITY: WAUKESHA

ORG_NAME: AMERICAN SOCIETY OF GENE & CELL THERAPY

ORG_STATE: WI

PHR: American Society of Gene and Cell Therapy PA-21-151 PROJECT NARRATIVE This project facilitates the professional development of early-career professionals by supporting their travel expenses to our Annual Meeting to present their abstracts. The strength of the scientific early- career professional workforce is essential to the field’s future discoveries and clinical developments. Gene and cell therapy stands at the forefront of treating major chronic and rare diseases, and therefore, fortifying the future experts of the field is highly beneficial to enhancing public health and treating disease.

PI_NAMEs: BARRETT, DAVID  (contact)

PROGRAM_OFFICER_NAME: CHEN, ALICE

PROJECT_TERMS: American;Award;Awareness;career;Cell Therapy;Chronic Disease;clinical application;clinical development;Clinical Trials;cost;Databases;Development;Disease;diversity and inclusion;Education;Event;experience;Fortification;Funding;Future;gene therapy;Goals;Grant;human disease;Improve Access;Individual;Industry;Institution;Investments;Knowledge;Learning;meeting abstracts;meetings;member;Mission;Outcome;Positioning Attribute;Postdoctoral Fellow;product development;Public Health;Rare Diseases;Reporting;Research;research and development;Research Personnel;Running;Societies;Students;success;Travel;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health

PROJECT_TITLE: ASGCT Annual Meetings 2022-24: Travel Awards and Underrepresented Minority Travel Awards


ADMINISTERING_IC: CK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

PHR: Project Narrative Healthcare-associated infections (HAIs) and antibiotic resistance (AR) are leading causes of morbidity and mortality worldwide. The studies proposed in this application seek to build on the considerable track record of the Penn-CHOP CDC Prevention Epicenter by further elucidating the epidemiology and impact of HAIs and AR as well as identifying and testing novel strategies to address these urgent problems.

PI_NAMEs: LAUTENBACH, EBBING  (contact)

PROJECT_TITLE: Southeastern Pennsylvania Adult and Pediatric Prevention Epicenter Network


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative  Crosslinking and bundling of thin filaments are responsible for the assembly of higher-order F-actin structures that support the unique cell structure, provide the scaffold for intracellular molecules and organelles, and, importantly, generate the force for membrane protrusions underlying cell motility. The proposed study investigates how actin bundling by fascin1 molecules enables the guided development of axonal projections for proper writing of the nervous system, and regulates the specific synaptic connections in the adult hippocampus. The work is directly relevant to public health concerning brain development and function.

PI_NAMEs: ZHENG, JAMES Q (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Actins;Adult;Axon;axon growth;axon guidance;axonal pathfinding;axonal sprouting;Biological Assay;Brain;Brain Diseases;brain tissue;Bundling;cancer cell;Cell Culture Techniques;cell motility;Cells;Cellular biology;Cellular Structures;Complex;CRISPR/Cas technology;crosslink;Cues;Cytoskeleton;Dendrites;dentate gyrus;Development;Disease;Electrophysiology (science);Embryonic Development;Employment;Environment;Epilepsy;Event;Exhibits;extracellular;F-Actin;Family;fascin;Filopodia;Fingers;Genes;granule cell;Growth Cones;hippocampal pyramidal neuron;Hippocampus;Image;in vivo;Injections;insight;Interneurons;Knock-out;Knowledge;Label;Maintenance;Membrane;Microfilaments;migration;Molecular;molecular targeted therapies;Morphology;mossy fiber;Motility;Mus;Neoplasm Metastasis;nerve injury;Nervous System;neural circuit;neurodevelopment;neuron development;Neurons;neurotransmission;Organelles;Pathologic;Physiological;Play;Property;Protein Isoforms;Proteins;Public Health;Regulation;Research;response;Role;scaffold;Side;Signal Transduction;spatiotemporal;Structure;superresolution imaging;Synapses;Synaptic Transmission;synaptogenesis;Testing;Therapeutic Intervention;Thin Filament;Thinness;Time;Viral;Work;Writing

PROJECT_TITLE: Fascin in brain development and function

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: HADLEY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative: Abnormal activation of inflammasomes can initiate undesirable inflammatory responses associated with the progression of chronic inflammatory diseases. Nanomaterials that are used to target immune cells at the disease site to modulate immune responses have been shown to non-specifically activate inflammasomes potentially exacerbating the disease, however this is poorly understood. The central vision of my program is to perform a comprehensive understanding of nanomaterial properties that drive inflammasome activation and the mechanisms behind their activity for their effective use across a variety of biological applications.

PI_NAMEs: KULKARNI, ASHISH A. (contact)

PROJECT_TERMS: Address;Affect;Biological;Biology;Caspase;Cell Communication;Cells;Characteristics;Chronic;chronic inflammatory disease;cytokine;Defense Mechanisms;Dendritic Cells;design;Development;Diagnostic;Disease;Engineering;engineering design;Homeostasis;imaging platform;imaging probe;Immune;Immune response;Immune system;Immune Targeting;immunoengineering;Immunology;immunoregulation;Immunotherapy;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;Innate Immune System;Invaded;Libraries;Macrophage;Monitor;monocyte;nanomaterials;nanopolymer;nanoscience;neutrophil;next generation;novel;Polymers;prevent;programs;Property;protein complex;Reporting;Research;Role;Signal Pathway;Site;Structure;Surface;System;Testing;Time;tool;Vision

PROJECT_TITLE: Polymeric Nanomaterials for Probing and Modulating Innate Immune Responses


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Dr. Bornfeldt's long-term goals are to establish new metrics to predict the risk of cardiovascular disease in humans with diabetes and identify novel mechanisms for targeted therapeutics. This project has strong translational significance, and will increase our understanding of novel treatment strategies for cardiovascular risk associated with diabetes – one of the major health issues of our time.

PI_NAMEs: BORNFELDT, KARIN E. (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Acceleration;Adult;Age;Apolipoproteins;Arterial Fatty Streak;Atherosclerosis;Biological Assay;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Child;Chylomicrons;clinically significant;Complications of Diabetes Mellitus;Data;Diabetes Mellitus;Diabetic mouse;endoplasmic reticulum stress;Event;Flow Cytometry;Glycolysis;Goals;Health;Human;Hypertriglyceridemia;Incidence;Insulin-Dependent Diabetes Mellitus;LDL Cholesterol Lipoproteins;Lesion;Link;Lipoproteins;Macrophage;Methods;Myocardial Infarction;Non-Insulin-Dependent Diabetes Mellitus;Normal Range;novel;novel therapeutic intervention;particle;Patients;Persons;Plasma;Population;Positioning Attribute;Prediabetes syndrome;Prevalence;prevent;Prevention strategy;Prospective Studies;Proteomics;Reporting;Residual state;Risk Factors;risk prediction;Serum;Severities;single-cell RNA sequencing;Stroke;targeted treatment;Time;treatment strategy;Triglyceride Metabolism;Triglycerides;Very low density lipoprotein

PROJECT_TITLE: Identifying new strategies for prevention of cardiovascular complications of diabetes


NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Narrative  Despite its position as a leading cause of maternal death and major contributor to maternal and perinatal morbidity, there is no effective drug treatment to prevent preeclampsia (PE). At present, the only effective treatment for PE is early delivery of the baby and placenta. Based on recent studies and on preliminary data presented in this application, we propose that the NLRP3 inflammasome is a novel therapeutic target for the treatment of PE.

PI_NAMEs: CORNELIUS, DENISE CRESHUN (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Adaptor Signaling Protein;Address;Affect;Animal Model;Attenuated;Binding;Biochemical;Blood Pressure;Blood Vessels;CASP1 gene;Caspase;Cells;Cessation of life;Chronic;Clinical Research;Complex;cytokine;Data;effective therapy;Enzymes;Etiology;Event;fetal;Fetal Growth Retardation;Fetal Weight;Genetic Complementation Test;Goals;Hypertension;hypoperfusion;Immune;immune activation;Immune system;Immune System Diseases;Immunologic Factors;Impairment;improved;in vivo;Inflammasome;Inflammation;Infusion procedures;inhibitor;Interleukin-1;Interleukin-1 beta;Ischemia;kidney dysfunction;Knowledge;Link;maternal hypertension;maternal morbidity;Maternal Mortality;Mediating;Modeling;Molecular;Morbidity - disease rate;Natural Killer Cells;new therapeutic target;NK Cell Activation;novel;novel therapeutic intervention;novel therapeutics;Nucleotides;Pathogenesis;pathophysiology of preeclampsia;Pathway interactions;Perfusion;perinatal morbidity;pharmacologic;Pharmacotherapy;Physiological;Placenta;polarized cell;Positioning Attribute;Pre-Eclampsia;Pregnancy;pregnant;Pregnant Women;pressure;prevent;Production;protein expression;Rattus;receptor;Renal function;Reporting;Research;response;Role;Signal Transduction;Techniques;Testing;therapeutic target;Uterus;Vascular Diseases;Woman

PROJECT_TITLE: Hypertension, Inflammation, and Vascular Function

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Receptors for a brain peptide called nociceptin/orphanin FQ (NOP) show promise as targets for new, more effective medications for alcohol use disorder (AUD), which are desperately needed. Using behavioral procedures and brain imaging techniques we will characterize the relationship between NOP receptors and alcohol consumption in monkeys, and will test potential medications in a highly translational model. Taken together, the results of these studies will provide novel, clinically relevant information to support NOP receptors as targets for new medications for AUD.

PI_NAMEs: CZOTY, PAUL W. (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: Acute;Adolescent;Adult;Adverse effects;Affect;Agonist;alcohol abstinence;Alcohol abuse;alcohol availability;Alcohol consumption;alcohol sensitivity;alcohol use disorder;antagonist;Behavioral;Brain;Brain imaging;Buprenorphine;Catalogs;Chronic;chronic alcohol ingestion;clinically relevant;cost;Data;design;Dose;drinking;drug action;drug development;drug efficacy;efficacious treatment;Ethanol;Female;Food;Heavy Drinking;Hour;Husband;imaging study;Imaging Techniques;indexing;Individual;Laboratories;Long-Term Effects;Macaca mulatta;male;Measures;Methods;Modeling;Monitor;Monkeys;National Institute on Alcohol Abuse and Alcoholism;nociceptin;nonhuman primate;novel;novel therapeutics;Opioid Peptide;ORL1 receptor;Parents;Peptide Receptor;Peptides;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Positron-Emission Tomography;preclinical study;Procedures;Public Health;radiotracer;receptor;Recovery;Research;research clinical testing;Research Personnel;response;Rodent Model;Role;Running;Scanning;Sex Differences;side effect;Strategic Planning;Testing;Time;timeline;translational approach;translational model;translational study

PROJECT_TITLE: NOP Receptors in nonhuman primate models of AUD

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: MADISON

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Public Health Relevance While isolated aspects of substance misuse are improving, such as tobacco cessation and opioid prescribing practices, enormous service gaps persist that allow the ongoing and enormous negative impacts of risky and problem substance use. Further, these negative impacts place a particular burden on gender and ethnic minorities and other disadvantaged populations and communities. The proposed conference will bring together a multidisciplinary gathering of approximately 300 experts in diverse related fields including substance abuse treatment, epidemiology, prevention research, HIV risk, health services research, health disparities, primary care, psychology, social work, and industrial and systems engineering. Conference organizers aim to increase research capacity by increasing the level of collaboration between established investigators and we will specifically encourage involvement by more junior researchers with particular focus upon recruitment of scientists from underrepresented gender and ethnic minorities.

PI_NAMEs: BROWN, RANDALL T (contact);QUANBECK, ANDREW

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: addiction;Address;Area;Award;career;Collaborations;cost;design;Development;Disease;Disparity;Disparity population;Engineering;Epidemic;Epidemiology;ethnic minority;Funding;Future;gender minority;health disparity;Health Personnel;Health Services;Health Services Research;HIV risk;implementation science;improved;Industrialization;interest;Mainstreaming;marginalized population;Medicine;Mentors;minority investigator;Modeling;multidisciplinary;National Institute of Drug Abuse;neighborhood disadvantage;Patients;Personal Satisfaction;Policy Maker;prescription opioid;prevent;Prevention Research;prevention service;Primary Care;programs;Psychology;Public Health;public health relevance;recruit;Reporting;Research;Research Personnel;safety outcomes;Scientist;service delivery;service gap;Services;Social Work;Specialist;substance abuse treatment;substance misuse;substance use;Substance Use Disorder;Surgeon;symposium;System;Thinking;Tobacco Use Cessation;Travel;treatment services;United States

PROJECT_TITLE: The Addiction Health Services Research (ASHR) conference


NIH_SPENDING_CATS: Infectious Diseases;Kidney Disease;Urologic Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE E. coli bacteria are known to utilize surface fibers called type 1 pili to bind to the bladder surface during bladder infections. We have discovered that these pili are also important in causing kidney infections, and we have identified a receptor to which the pili bind. In this project, we will study how this binding allows kidney infections to be initiated, develop ‘molecular snapshots’ of the binding interaction, and determine whether this receptor is important for E. coli binding in other body sites.

PI_NAMEs: HUNSTAD, DAVID  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acute;Adhesives;Affinity;Apoptosis;Attention;Bacteria;Bacterial Adhesins;Bacterial Adhesion;bacterial community;Behavior;Binding;Biochemical;Biological;Bladder;Cadherin Domain;Cadherins;cell type;Cells;Clinical;Colon;Communities;Confocal Microscopy;CRISPR screen;Cryoelectron Microscopy;Crystallization;Cystitis;desmoglein 2;Ductal Epithelium;Epithelial Cells;Epithelium;Escherichia coli;Escherichia coli Adhesins;Escherichia coli Infections;experimental study;extracellular;Extracellular Domain;Family;Fiber;Gastrointestinal tract structure;Genetic;Genome;gut colonization;Human;human tissue;In Vitro;in vitro Model;in vivo;Inbred C3H Mice;Infection;Infective cystitis;inhibitor;Intercellular Junctions;intestinal epithelium;Investigation;Kidney;kidney infection;Knock-out;Knockout Mice;Lectin;Link;Mannose;Mannosides;Mediating;Mediator;Modeling;Molecular;Molecular Chaperones;Monoclonal Antibodies;mouse model;Mus;Mutation;Nephrons;novel;pathogen;Pathogenesis;Pathway interactions;Peptides;pharmacologic;Pilum;Polysaccharides;Process;protein purification;Proteins;Publishing;receptor;Recurrence;renal abscess;renal epithelium;response;Role;Site;small molecule;small molecule inhibitor;Specific qualifier value;Structure;sugar;Surface;System;Testing;Therapeutic;Tissues;Tubular formation;type 1 fimbriae receptor;Urinary tract;Urinary tract infection;Urine;Uropathogenic E. coli;Vaccination;Variant;Virulence;X-Ray Crystallography

PROJECT_TITLE: Novel Type 1 Pilus Receptors in Pyelonephritis and Recurrent UTI

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: This proposal will explore the role of long non-coding RNAs in epigenetic chromatin remodeling mechanisms associated with Alzheimer’s disease (AD). The major goal is to investigate how the long non-RNA Neat1 initiates cell-type specific transcriptional programs in response to AD pathology. These studies will lead to a better understanding of long non-coding RNAs in hippocampal function in AD and can result in novel epigenetic-based therapies to improve cognitive dysfunction in AD.

PI_NAMEs: LUBIN, FARAH DOMINIQUE (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: 3xTg-AD mouse;Age;Age Months;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Animal Disease Models;Area;Astrocytes;astrogliosis;Brain;Brain region;Cell Nucleus;Cell Separation;cell type;Cells;Chromatin;chromatin isolation by RNA purification sequencing;chromatin remodeling;Cleavage Under Targets and Release Using Nuclease;Coupled;Data;Data Set;Disease Progression;DNA Methylation;Dorsal;Endocytosis;Enzymes;Epigenetic Process;epitranscriptome;experimental study;Fluorescent in Situ Hybridization;Gene Expression Profile;Genes;Genetic Markers;Genetic Transcription;Goals;Heterozygote;hippocampal pyramidal neuron;Hippocampus;histone methylation;histone methyltransferase;histone modification;Histones;Homozygote;human disease;immunoreactivity;Impaired cognition;improved;in silico;In Vitro;insight;Intervention;J20 mouse;knock-down;Knock-in;Knowledge;Learning;long term memory;Magnetism;Mammals;Mass Spectrum Analysis;Mediating;Memory;Memory impairment;Memory Loss;mouse model;mutant;Neurons;normal aging;novel;overexpression;Pathogenesis;permissiveness;Pilot Projects;Play;Post-Translational Protein Processing;programs;promoter;Proteins;recruit;Regulation;Regulator Genes;Research;resilience;response;RNA;RNA purification;Role;sex;single nucleus RNA-sequencing;single-cell RNA sequencing;small hairpin RNA;Small Interfering RNA;tau-1;Testing;Therapeutic;Transgenic Organisms;Untranslated RNA;Vimentin

PROJECT_TITLE: The role of IncRNA Neat1 in Alzheimer's disease and related memory deficits


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Congenital Structural Anomalies;Digestive Diseases;Genetics;Human Genome;Infant Mortality;Lung;Pediatric;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Diaphragmatic hernias and cardiovascular malformations are serious birth defects. In this study, we will use bioinformatics and mouse models to identify genes that cause these birth defects and to learn how they work. These experiments will help us to understand how the diaphragm and heart form prior to birth and may ultimately lead to new ways of treating or preventing these birth defects.

PI_NAMEs: SCOTT, DARYL ARMSTRONG (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: 8p23.1;Acceleration;Affect;Algorithms;Animal Model;Binding;biochip;Bioinformatics;bioinformatics tool;Biological Assay;Birth;Candidate Disease Gene;Cardiac;cardiogenesis;Cardiovascular system;Child;Chromosome Deletion;Chromosomes;Clinical;Clinical Data;Clinical Research;Congenital Abnormality;congenital anomaly;Congenital diaphragmatic hernia;Cytogenetics;Data;data integration;data modeling;Death Rate;Development;Diaphragmatic Hernia;Discipline;Disease;dosage;Embryo;Encyclopedias;Endocardium;Endothelium;epigenomics;experimental study;Foundations;GATA4 gene;gene discovery;gene interaction;Genes;Genetic;Genetic Transcription;genome database;Genomic Segment;Genomics;Goals;Grant;Heart;Hernia;Human;human disease;In Situ Hybridization;Individual;innovation;Intervention;Knowledge;Laboratories;large scale data;Learning;Life;LoxP-flanked allele;Luciferases;machine learning algorithm;malformation;Maps;Mesenchymal;microdeletion;MicroRNAs;Modeling;Molecular;molecular sequence database;Morbidity - disease rate;mouse genome;mouse model;Mus;Newborn Infant;next generation sequencing;novel;Ontology;Pathogenicity;Pathway Analysis;Pathway interactions;Phenotype;prevent;preventive intervention;Process;Proteins;Publishing;Recurrence;Research;Research Personnel;research study;Respiratory Diaphragm;Role;septal defect;Source;SOX7 gene;Syndrome;Techniques;Therapeutic Intervention;Training;transcription factor;transcriptome sequencing;United States National Institutes of Health;Update;Validation;web based interface;WNT4 gene;Work

PROJECT_TITLE: Mechanisms of Abnormal Diaphragm and Cardiac Development

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: TNF (tumor necrosis factor) is a critical innate immune response gene that has a profound impact on a number of autoimmune and infectious diseases outcomes. We have discovered long-range regulatory elements, which control expression of TNF in a cell-type specific manner. Understanding how these elements control TNF gene expression will provide fundamental knowledge about the regulation of TNF and potentially other genes and we expect will lead to novel and specific therapeutic strategies for autoimmune and infectious disease where TNF causes immune pathology.

PI_NAMEs: GOLDFELD, ANNE  (contact)

PROJECT_TERMS: 2019-nCoV;Acute;Architecture;Area;Arthritis;Autoimmune Diseases;CCCTC-binding factor;Cell Line;cell type;Cells;ChIP-seq;Chromatin;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Communicable Diseases;Data;Data Set;Disease;disease model;Disease Outcome;Distal;Elements;Enhancers;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;genomic locus;Genomic Segment;Genomics;Goals;Hi-C;Human;IL6 gene;Immune;Immune Response Genes;Inbred BALB C Mice;Infection;Innate Immune Response;insight;Interferon Type II;Knowledge;Ligands;LTA gene;LTB gene;Macrophage;Mediating;Molecular Conformation;monocyte;Mouse Strains;Mus;Mycobacterium tuberculosis;next generation sequencing;nonhuman primate;novel;Pathology;Phylogenetic Analysis;programs;recruit;Regulation;Regulator Genes;Regulatory Element;RNA;RNA Viruses;Role;Sepsis;Site;Stimulus;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Three-dimensional analysis;TNF gene;Untranslated RNA;XCL1 gene

PROJECT_TITLE: Discovery of novel regulatory territories in the TNF/LT locus

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Genetics;Lung;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Idiopathic pulmonary fibrosis (IPF) is a common and deadly scarring lung disease for which there is no cure. The development and progression of IPF proceeds when myofibroblasts – scar forming and contractile cells that differentiate from fibroblasts – fail to de-differentiate following lung injury. This proposal seeks to investigate the mechanisms by which myofibroblasts can be de-differentiated and cleared – thereby enabling fibrosis resolution – as well as to support the career development of a promising and committed physician scientist.

PI_NAMEs: FORTIER, SEAN MICHAEL (contact)

PROJECT_TERMS: Adenylate Cyclase;Affect;Animal Model;Antigens;Apoptosis;Apoptotic;Architecture;Area;Award;Bioinformatics;Biology;Bleomycin;career;career development;cell dedifferentiation;Cell Differentiation process;Cell Line;Chemosensitization;Cicatrix;Clinical;Clinical Data;clinical training;Collagen;CRISPR/Cas technology;Critical Care;Cyclic AMP;Data;Development;Development Plans;Educational workshop;Effector Cell;Environment;Exhibits;experience;Fellowship;Fibroblasts;Fibrosis;fibrotic lung;fibrotic lung disease;Fluorescence Microscopy;Forskolin;Functional disorder;G-Protein-Coupled Receptors;Gases;Gene Expression;Gene Expression Profile;Generations;Genes;Grant;GTP-Binding Protein alpha Subunits, Gs;Human;idiopathic pulmonary fibrosis;Image;Immunofluorescence Microscopy;Impairment;In Vitro;in vivo;in vivo Model;Individual;inhibitor;Institution;Internal Medicine;Investigation;Knock-out;Knockout Mice;Knowledge;Ligation;Lung;Lung Diseases;lung injury;Mediating;Medicine;meetings;Mentors;Messenger RNA;Modeling;Molecular;Molecular Biology;mouse model;mRNA Stability;multidisciplinary;Mus;Myofibroblast;novel;Patients;pharmacologic;Phenotype;Phosphodiesterase Inhibitors;Phosphorylation;Physicians;Post-Transcriptional Regulation;posttranscriptional;Process;Proliferating;Proteins;Pulmonary Fibrosis;Reagent;Regulation;Research;research and development;Research Design;Research Personnel;Resistance;Resolution;responsible research conduct;restoration;RNA;RNA-Binding Proteins;Role;Scientist;Second Messenger Systems;Signal Pathway;Signal Transduction;skills;System;Techniques;Testing;Therapeutic;Therapeutic Effect;Time;Tissues;trafficking;Training;Transcript;transcriptome sequencing;transcriptomics;Transgenic Animals;Transgenic Mice;Translating;translational impact;translational scientist;Translations;Untranslated RNA;Wild Type Mouse;wound healing;Writing

PROJECT_TITLE: Lung Myofibroblast De-Differentiation and Fibrosis Resolution Depend on cAMP-mediated Inhibition of HuR.

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Allergic Rhinitis (Hay Fever);Asthma;Clinical Research;Clinical Trials and Supportive Activities;Health Effects of Indoor Air Pollution;Lung

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: 8. Project Narrative This mechanistic clinical trial will be conducted in house dust mite-sensitive persons with allergic rhinitis and persistent mild-to-moderate allergic asthma to assess the role of epithelial integrity versus inflammation in driving the heterogeneity in disease severity assayed in response to exposure to house dust mites in an environmental chamber. Assessments are made before, during, and after a 22-week course of dupilumab.

PI_NAMEs: AHUJA, SUNIL K (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: airborne allergen;airway epithelium;Allergic;Allergic rhinitis;antiviral immunity;Asthma;asthmatic;Attenuated;attenuation;Automobile Driving;Biological Assay;Biological Products;CCL18 gene;Classification;Clinical Trials;comorbidity;Coupling;Data;Depressed mood;Disease;disease model;Dose;Double-Blind Method;Environment;epithelial injury;epithelial repair;Epithelium;experience;Exposure to;Extrinsic asthma;FDA approved;filaggrin;gain of function;Genes;genome wide association study;Heterogeneity;Hour;Immune response;immunological status;Individual;Individual Differences;Inflammation;Inflammatory;Influentials;innovation;insight;Interleukin 4 Receptor;Interleukin-13;Interleukin-4;Intervention;loss of function;Mediating;Mediator;Modeling;Monitor;Monoclonal Antibodies;multidisciplinary;multimodality;Nose;novel;Outcome;Participant;Pathogenesis;Pathway interactions;peripheral blood;Persons;Pharmaceutical Preparations;Phase;Phenotype;Placebo Control;Placebos;predictive modeling;Proxy;Pyroglyphidae;Randomized;Recrudescences;reduce symptoms;Reporting;resilience;Resistance;Resources;response;rhinoconjunctivitis;Role;Sampling Studies;Series;Severities;Severity of illness;Symptoms;System;systemic inflammatory response;Testing;Therapeutic Intervention;therapeutic target;Time;trait;transcriptomics;treatment response

PROJECT_TITLE: Mechanistic clinical trial of blocking the IL-4/13 axis in asthmatics precision phenotyped in an aeroallergen challenge chamber before, during and after receipt of dupilumab


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE To address high unmet need for postpartum family planning (PPFP) in Rwanda, we developed and pilot tested our `C4' intervention (informed by Couples/clients, Clinic providers, Champions, and Community health workers), which significantly increased the use of PPFP in government clinics. We now propose to use an implementation science framework to test the hypothesis that C4 is adaptable to large-scale implementation, cost-effective, and sustainable. C4 could dramatically reduce unintended pregnancy and abortion and improve birth spacing and maternal and newborn health.

PI_NAMEs: WALL, KRISTIN MARIE (contact)

PROGRAM_OFFICER_NAME: ALLEN, CATHERINE LEIGH

PROJECT_TERMS: abortion;Academic advising;acceptability and feasibility;Address;Adoption;Africa;Area;Birth Intervals;Breast Feeding;Capital;Chicago;Child;Cities;Client;Client satisfaction;Clinic;Communities;Community Health Aides;comparison intervention;Consolidated Framework for Implementation Research;Contraceptive methods;Contraceptive Usage;cost;cost effective;cost effectiveness;cost estimate;Cost Savings;Cost utility;Counseling;Country;Couples;Data;Decision Making;design;Diffusion;Education;Effectiveness;effectiveness evaluation;effectiveness/implementation study;Evaluation;experience;Family Planning;Family Planning Programs;Goals;Government;Happiness;Health;Health care facility;Implant;implementation cost;implementation framework;implementation process;improved;incremental cost-effectiveness;innovation;Intervention;Interview;Intrauterine Devices;low and middle-income countries;Maintenance;Maternal Health;maternal morbidity;Maternal Mortality;Measures;Methods;Modeling;Morbidity - disease rate;mortality;National Institute of Child Health and Human Development;neonatal health;neonatal morbidity;Neonatal Mortality;novel;Nurses;organizational readiness;Outcome;Patients;pilot test;Play;post pregnancy;Postpartum Period;Postpartum Women;Pregnancy;Pregnant Women;Prevention;Professional counselor;promoter;Provider;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;reversible contraceptive;Rwanda;Services;side effect;social;standard of care;Testing;theories;tool;unintended pregnancy;uptake;Woman;Women's Health;Work;World Health Organization;Zambia

PROJECT_TITLE: Implementation and evaluation of a large-scale postpartum family planning program in Rwanda

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(02)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: Newark

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: (No changes from Original Proposal) The treatment of human disease is highly dependent on efficient synthetic access to the nitrogen-containing small molecules that constitute the majority of pharmaceutical agents. The need for greater efficacy, safety, and selectivity in new treatments drives increases in molecular complexity, creating urgent need for new synthetic methods to prepare the required compounds. To meet this need, this proposal aims to develop new methods to construct complex, nitrogen-rich molecules by developing new reactions of highly oxidized nitrogen compounds and supporting technologies to enable their use.

PI_NAMEs: WATSON, DONALD ALLEN (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Alkylation;Amines;Automobile Driving;base;Biological;cancer cell;Catalysis;chemical reaction;Chemical Structure;Chemicals;Chemistry;Complex;Coupling;Cyclization;design;Development;Dioxanes;Disease;Drug Compounding;Drug Kinetics;drug structure;Felis catus;Follow-Up Studies;Health;Homo;Human;human disease;improved;inhibitor;innovation;innovative technologies;interest;invention;Letters;Ligands;Medical;Medicine;Methods;Molecular;Narcotics;Natural Products;nitroalkane;Nitrogen;nitrogen compounds;novel;novel therapeutics;Organic Synthesis;oxidation;Pharmaceutical Preparations;Pharmacologic Substance;Phosphines;Positioning Attribute;Process;programs;Publishing;Reaction;Research;Resistance;Route;Safety;small molecule;stereochemistry;strictamine;Synthesis Chemistry;System;Technology;Time;tool;Transition Elements;tumor necrosis factor-alpha inhibitor

PROJECT_TITLE: Novel Reactions of Electrophilic Nitrogen for Preparing Bioactive Molecules

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cystic Fibrosis;Gene Therapy;Genetics;Lung;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative: The proposed research is relevant to public health because genetic and acquired diseases affecting the airways pose major disease and economic burdens. This proposal takes an innovative approach using novel gene addition and base editing gene therapy strategies to correct cells lining the airways of a large animal model of cystic fibrosis. In this proposal, our goal is to create reagents with the ability to efficiently, safely, and persistently correct cystic fibrosis causing gene mutations in appropriate cell types.

PI_NAMEs: SINN, PATRICK L (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;Adenine;adenosine deaminase;Adenovirus Vector;Adenoviruses;aerosolized;Affect;airway epithelium;Animal Model;Anions;Basal Cell;base editing;base editor;Benchmarking;burden of illness;Categories;cDNA Expression;Cell Line;Cell surface;cell type;Cells;Chlorides;Chromosomes;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Control Animal;cost;CRISPR/Cas technology;Cystic Fibrosis;cystic fibrosis airway;Data;delivery vehicle;design;Disease;Disease Outcome;disease phenotype;DNA Transposons;Dose;Economic Burden;Electroporation;Endonuclease I;Engineering;Epithelial Cells;experimental study;expression vector;Family suidae;Fiber;functional restoration;gene correction;Gene Delivery;gene editing technology;Gene Mutation;gene repair;gene therapy;Gene Transfer;gene-editing approach;Generations;Genes;Genetic;Goals;gutless adenoviral vector;Hand;Heterozygote;Human;Hybrids;Immune response;improved;In Situ;In Vitro;in vivo;innovation;Interphase Cell;Knowledge;Lung Diseases;Measurement;Measures;Mendelian disorder;Methods;Mitotic;Mucolytics;Mucous body substance;Mus;mutant;Mutation;next generation sequencing;Nonsense Mutation;novel;nuclease;Outcome;Penetration;Persons;Phenotype;porcine model;premature;Production;promoter;Property;Proteins;Public Health;Pulmonary Cystic Fibrosis;Quality of life;Reagent;receptor;Regulator Genes;repair strategy;repaired;Reporting;Research;Site;small molecule;Speed;stem cells;success;System;Technology;Terminator Codon;Testing;therapeutic gene;therapeutic genome editing;therapeutic transgene;Tissues;tool;transduction efficiency;Tropism;vector;Viral;Viral Vector;VX-770;Zinc Fingers

PROJECT_TITLE: Life-long phenotypic correction of CF airways

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Clinical Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE  This proposal seeks to understand the impact of perinatal organizational factors, those created by the intersection of maternal and neonatal care in birth hospitals, on the care and health of mothers and infants. Focusing on the organizational structure of level of care (the risk-based services available at a hospital for mothers or infants) and the organizational culture of patient-centered care (the extent to which care is respectful of, and responsive to, individual patient preferences, needs and values), I will assess whether and how these factors interact to influence perinatal outcomes. Understanding the implications of perinatal organizational structure and culture is critical to improving the care and outcomes for the more than 3.5 million mothers and their infants who are born in the United States each year.

PI_NAMEs: HANDLEY, SARA CHRISTINE (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: 37 weeks gestation;Accounting;adverse outcome;Affect;Behavior;Belief;Biometry;Birth;Birth Certificates;California;care outcomes;Caring;Case Mixes;Childbirth;cohort;comorbidity;Complex;Complication;congenital anomaly;cost;Data;Data Set;Death Certificates;design;Discipline of obstetrics;Ethnic Origin;Future;Goals;health management;Health Services;Health Services Research;Healthcare;high risk;hospital organization;Hospitalization;Hospitals;improved;improved outcome;Individual;individual patient;Infant;Infant Care;infant outcome;innovation;Knowledge;Link;Maternal Health Services;maternal outcome;Mentors;Methodology;Mothers;multidisciplinary;Neonatal;neonatal care;neonatal outcome;Neonatology;Newborn Infant;novel;Organizational Culture;organizational structure;Outcome;Patient Preferences;Patient-Centered Care;Patients;Perception;Perinatal;Perinatal Care;perinatal outcomes;Policies;Population;population based;Pregnancy;pregnant;primary outcome;Proliferating;Provider;Race;Research;Research Personnel;Retrospective cohort;Risk;Safety;Science;secondary outcome;service organization;Services;severe maternal morbidity;Shapes;skill acquisition;Statistical Methods;structural determinants;Structure;study population;Surveys;System;theories;Training;United States;Variant;Work

PROJECT_TITLE: The impact of delivery hospital organizational structure and culture on perinatal outcomes

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DAVIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: This research will contribute basic knowledge about size of and socioeconomic conditions faced by the large population of Mexican American children of immigrants living in Mexico and the United States. By comparing U.S. citizen children in Mexico to children of Mexican immigrants in the United States, we will deepen our understanding of how migration and place of settlement impact child health and development.

PI_NAMEs: HAMILTON, ERIN R (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Affect;Attention;Back;Birth Place;Censuses;Characteristics;Child;Child Development;Child Health;Comparative Study;Country;Data;Economic Conditions;Economics;Emigrations;Enrollment;experience;Face;family structure;General Population;Generations;health care availability;Household;Household and Family;Immigrant;Immigration;Knowledge;Left;Mexican;Mexican Americans;Mexico;Migrant;migration;Parents;Persons;Policies;Policy Maker;Politics;Population;Population Sizes;Portraits;Research;Resources;Risk;Role;Schools;Security;Social Conditions;sociodemographics;socioeconomics;Structure;United States

PROJECT_TITLE: Migration and Place of Settlement and Child Health and Development:  U.S.-born children in Mexico and United States

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


NIH_SPENDING_CATS: Brain Disorders;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Pediatric;Precision Medicine;Prescription Drug Misuse;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The proposed precision perioperative analgesia platform and two case studies in children undergoing major surgery as well as nursing mothers following cesarean delivery in five CTSA hubs have transformative public health relevance. This collaborative CTSA application will overcome barriers in translating precision medicine evidence to perioperative practice settings as well as achieve the best-in-class post-surgical pain and opioid- related outcomes in millions of children undergoing painful surgeries and women undergoing cesarean delivery every year, by proactively identifying patients at risk for opioid-related serious adverse effects, risk of persistent surgical pain and opioid dependence, and personalizing opioid use with precision dosing.

PI_NAMEs: SADHASIVAM, SENTHILKUMAR  (contact)

PROGRAM_OFFICER_NAME: NAGEL, JOAN DAVIS

PROJECT_TERMS: ABCB1 gene;Absence of pain sensation;Acceleration;Acute;Address;Adult;Adverse effects;adverse outcome;Analgesics;Anoxic Encephalopathy;antagonist;Brain Death;Breastfed infant;Breathing;Caring;Case Study;Cesarean section;Cessation of life;Child;Chronic;chronic pain;Clinical;clinical decision support;clinical practice;Codeine;cost effectiveness;CYP2B6 gene;CYP2D6 gene;Dependence;Deterioration;digital;digital tool;Discipline of Nursing;Dose;Drug Kinetics;Economic Burden;Effectiveness;Electronic Health Record;electronic patient reported outcomes;Enzymes;evidence base;follow-up;Genetic Risk;genetic risk factor;genetic variant;Genetic Variation;Genomics;Genotype;Guidelines;Heritability;high risk;Hydrocodone;improved;Individual;Infant;Infant Mortality;Infrastructure;innovation;inpatient surgery;Insurance Coverage;Knowledge;Length of Stay;Life;Link;Liver;Metabolism;Methadone;Methods;Mothers;multidisciplinary;N-Methylaspartate;neonate;Newborn Infant;Nursing infant;nursing mothers;Operative Surgical Procedures;Opiate Addiction;Opioid;Opioid Analgesics;opioid epidemic;opioid mortality;opioid overdose;opioid use;Other Genetics;Outcome;Outpatients;Oxycodone;Oxymorphone;Pain;Pain management;pain relief;Patients;Perioperative;personalized care;personalized decision;personalized intervention;Population;Postoperative Nausea and Vomiting;Postoperative Pain;Postoperative Period;Postpartum Depression;practice setting;precision medicine;prescription opioid;prevent;Productivity;Protocols documentation;Public Health;public health relevance;Publishing;Risk;risk prediction;Safety;Science;socioeconomics;Spinal Fusion;Surgical Management;surgical pain;Testing;Tramadol;Translating;translational barrier;translational potential;Translational Research;Variant;Ventilatory Depression;Vulnerable Populations;Woman

PROJECT_TITLE: Perioperative Precision Medicine: Translating Science to Clinical Practice to Improve Safety and Efficacy of Opioids in Neonates, Children and Nursing Mothers


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Dietary Supplements;Heart Disease;Hypertension;Nutrition;Pediatric;Pregnancy;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: PROJECT NARRATIVE  Multiple studies hypothesize that environmental factors in utero program patterns of fetal and infant growth that result in increased susceptibility to hypertension (HTN) early in life. We found that transplanted hematopoietic stem cells from embryos exposed to vitamin D deficiency in utero are capable of transferring HTN to vitamin D-sufficient adult mice. In this application we will explore the role of the genetic program induced in macrophages by vitamin D deficiency in utero in the development of HTN, and whether antenatal vitamin D supplementation in humans and rodents reduces HTN in the offspring.

PI_NAMEs: BERNAL-MIZRACHI, CARLOS  (contact)

PROGRAM_OFFICER_NAME: KIRBY, RUTH

PROJECT_TERMS: 11 year old;Address;Adolescence;Adult;Age;American;antenatal;arterial stiffness;Attenuated;Biological Assay;biomarker identification;Blood Pressure;blood pressure elevation;Blood Vessels;Bone Marrow;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cells;Child;Childhood;Chronic;Coculture Techniques;cytokine;Data;Development;Diabetes Mellitus;Diastolic blood pressure;early onset;early pregnancy;Embryonic Development;embryonic stem cell;Environmental Risk Factor;Epigenetic Process;Exposure to;fetal;Fetal Liver;fetus cell;First Pregnancy Trimester;Genetic;Goals;Growth;Health;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Human;Hypertension;Immune;improved;in utero;in vivo;Incidence;Infant;Inflammation;Inflammatory;Insulin Resistance;Juxtaglomerular Cell;Kidney;Knockout Mice;Life;Life Expectancy;Link;Macrophage;Maintenance;Measurement;Mediating;Modeling;monocyte;mortality;Mothers;Multivitamin;Mus;Myeloid Cells;novel;nutrition;Nutritional Study;Obesity;offspring;Organ;Parents;Pathway interactions;Pattern;Peritoneal Macrophages;Phenotype;Physiological;Placebos;Plasma;Play;postnatal;Predisposing Factor;Predisposition;Pregnancy;pregnant;Pregnant Women;premature;prevent;Production;programs;Quality of life;Randomized, Controlled Trials;Recording of previous events;Renin;Risk;Rodent;Rodent Model;Role;screening;Serum;Signal Transduction;specific biomarkers;Systemic blood pressure;Testing;Time;transplant model;Transplant Recipients;Transplantation;United States;Up-Regulation;Vitamin D;Vitamin D Deficiency;Vitamin D supplementation;Vitamin D3 Receptor;Woman;Youth

PROJECT_TITLE: Vitamin D Deficiency, Insulin Resistance and Cardiovascular disease

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: 100.8 PROJECT NARRATIVE HIV testing and service uptake are infrequent among people who inject drugs (PWID) in the United States. In partnership with a community-based syringe service program (SSP), this project will develop the SSP-based “Prevention Ambassadors” (PA) intervention to promote HIV testing and service uptake among PWID via the secondary distribution (i.e., peer delivery) of HIV self-testing (HIVST) kits with local HIV service information and referrals to HIV service navigation in the social networks of SSP clients (i.e., PWID). The PA intervention will then be piloted to assess its preliminary effects, acceptability, and feasibility among PWID in the Ending the HIV Epidemic priority jurisdiction of Riverside County, California.

PI_NAMEs: BAZZI, ANGELA ROBERTSON;PINES, HEATHER ALISA (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Acceleration;acceptability and feasibility;AIDS prevention;Area;Authorization documentation;Behavior;California;care systems;Caring;Characteristics;Client;Collaborations;Communities;County;Data;Diagnostic Reagent Kits;Diffusion of Innovation;Disease Outbreaks;efficacy trial;empowerment;Epidemic;experience;Face;Fentanyl;follow-up;Frequencies;Future;Goals;harassment;Harm Reduction;Health;health care service utilization;health care settings;HIV;HIV diagnosis;Homelessness;Human immunodeficiency virus test;indexing;Individual;Information Services;Injecting drug user;injection drug use;Injections;Intervention;Interview;Medical;Medical Records;member;Methamphetamine;Methods;Naloxone;Needle-Exchange Programs;Network-based;Newly Diagnosed;novel;opioid use;Outcome;peer;Phase;pilot test;pilot trial;Police;polysubstance use;pre-exposure prophylaxis;Prevention;prevention service;preventive intervention;Process;Randomized;recruit;Research;self testing;service engagement;service providers;service uptake;Services;sexual risk behavior;social;social influence;Social Network;social stigma;standard of care;Sterility;stimulant use;success;Surveys;Syringes;Testing;testing uptake;theories;Training;transmission process;Transportation;trend;Trust;United States;uptake;Visit;Work

PROJECT_TITLE: Prevention Ambassadors: an HIV self-testing intervention to promote HIV service engagement in the networks of SSP clients


ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Fidelity in directional motility is critical for development. This proposal addresses an outstanding question that remains a major impasse in the field of developmental neurobiology: How does a single extracellular morphogen, the secreted glycoprotein netrin-1, function as both a both a diffusive cue vs a local, adhesive cue, and both an attractive cue and a repulsive cue.

PI_NAMEs: GUPTON, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Address;Adhesives;Affect;Anatomy;Architecture;automated analysis;Axon;Behavior;Behavioral;Biochemical;Biochemistry;Biological Assay;Body System;Cell membrane;cell motility;Chemotaxis;Cues;Data;Development;developmental neurobiology;Embryo;Environment;extracellular;Fluorescence Resonance Energy Transfer;Future;Genes;genetic manipulation;Glycoproteins;glycosylation;Goals;high reward;high risk;Human;Image;Impairment;In Vitro;in vivo;insight;Invertebrates;Investigation;mechanotransduction;Mediating;Microfluidics;Modeling;Modification;Molecular;Morphogenesis;morphogens;Motility;mouse model;Mus;mutant;Mutation;netrin receptor;neural;Neurons;novel;NTN1 gene;Proteomics;Protocols documentation;receptor;response;sensor;Signal Transduction;Solubility;spatiotemporal;Techniques;Total Internal Reflection Fluorescent;Work

PROJECT_TITLE: Netrin Glycosylation Influences Chemotaxis and Haptotaxis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-R(02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Palliative Care

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative The National Academy of Medicine and two recent National Institute on Aging and National Institute of Health sponsored workshops on geriatric palliative care reported extensive national data from multiple settings and disease categories of a high prevalence of physical, psychosocial, and financial suffering associated with serious illness for older adults and their caregivers. Our R33 proposal addresses this public health challenge by expanding and enhancing an existing national research organization to leverage scarce NIH monies to provide research technical assistance, research funding, and support for initiatives to build and solidify the community and network of geriatric palliative care researchers throughout the United States.

PI_NAMEs: ALDRIDGE, MELISSA DIANE (contact);MORRISON, R. SEAN

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Academy;Address;age group;Aging;Alzheimer's disease related dementia;Area;Behavioral;cancer risk;care fragmentation;care systems;Caregivers;Caring;Categories;Cause of Death;Cessation of life;Chronic;Chronic Disease;Clinical;Collaborations;Communication;Communities;Complex;Consent;Data;Data Set;Dedications;Dementia;Development;Disease;Distress;Educational workshop;Elderly;Enrollment;evidence base;experience;Family;Family Caregiver;family support;Fostering;Foundations;frailty;Functional dependence;Funding;Generations;Grant;Grant Review;Health Services Research;Healthcare;Heart Diseases;High Prevalence;human old age (65+);Improve Access;improved;Infrastructure;Institution;interest;Investments;K-Series Research Career Programs;Knowledge;Lead;Leadership;Longevity;Measures;Medical Education;Medicine;meetings;Mentorship;Morbidity - disease rate;multiple chronic conditions;multiple datasets;National Institute on Aging;novel;older adult;Palliative Care;Patients;Persons;Philanthropic Fund;physical symptom;Physicians;Population;population based;Population Growth;Population Research;Postdoctoral Fellow;Program Reviews;programs;psychological symptom;psychosocial;Public Health;Quality of life;Recommendation;Recording of previous events;Reporting;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Priority;Research Project Grants;Research Support;Resources;Science;Scientist;senior faculty;Site;skills;Societies;support network;Support System;Surveys;Talents;Training;United States;United States National Institutes of Health;virtual;webinar;Work;Writing

PROJECT_TITLE: Advanced-Stage Development of a Geriatric Palliative Care Research Infrastructure

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Substance Misuse

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Post-operative care is a time when excessive opioid prescribing occurs which can result in unnecessary harms, particularly to older and frail adults. Without a clear plan for reducing excessive opioid prescribing at hospital discharge after surgery such as with an opioid taper, opioids are often continued, which can result in unnecessary harms. This project will test the effectiveness of an EHR-embedded, provider-facing, patient-specific, discharge opioid taper support (DOTS) intervention to reduce excessive post-operative opioid prescribing.

PI_NAMEs: GROEGER, JUSTINA L (contact)

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: Absence of pain sensation;Acute Pain;Adult;Adverse event;Age;age related;Algorithms;arm;Attitude;Behavior;career;career development;Caring;Clinical Trials;Constipation;contextual factors;Data;Data Analyses;Delirium;design;Development;Development Plans;Dose;effectiveness evaluation;effectiveness testing;Electronic Health Record;Emergency Situation;Event;Face;falls;Fracture;frailty;Fright;Future;Goals;Health system;hip replacement arthroplasty;Hospitalization;Hospitals;human old age (65+);Hyperalgesia;improved;Instruction;Intervention;Interview;knee replacement arthroplasty;Knowledge;Manuals;Mentored Clinical Scientist Development Program;Mentors;morphine equivalent;mortality;multidisciplinary;older adult;Operative Surgical Procedures;Opioid;opioid epidemic;opioid mortality;opioid tapering;opioid therapy;opioid use;opioid use disorder;opioid withdrawal;Orthopedic Surgery;Orthopedics;Outcome;Overdose;Pain;Pain intensity;Pain management;Patient Discharge;Patient Outcomes Assessments;Patients;Pharmaceutical Preparations;Physical Dependence;Physical Function;Physicians;Physiological;pill;Planning Theory;Positioning Attribute;Postoperative Care;Postoperative Pain;Postoperative Period;prescription opioid;primary outcome;Procedures;Provider;Qualitative Research;Randomized;Randomized, Controlled Trials;Recommendation;Reporting;Research;research and development;Research Methodology;Research Personnel;Risk;Schedule;Sedation procedure;skills;Standardization;Surveys;Syndrome;Telephone;Testing;Time;Work

PROJECT_TITLE: A hospital discharge opioid taper support intervention to improve post-operative opioid prescribing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Biotechnology;Brain Disorders;Dementia;Immunization;Neurodegenerative;Neurosciences

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: The proposed project seeks to clarify tau pathogenesis with a focus on neuronal dysfunction and microglial activation. It will also examine novel therapeutic and diagnostic candidates that target pathological tau protein in Alzheimer's disease and related tauopathies. Hence, this research is very relevant to public health.

PI_NAMEs: SIGURDSSON, EINAR M (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Acute;Address;Age;Alzheimer's Disease;Amyloid;Anesthesia procedures;Animal Model;Antibodies;Antibody Therapy;awake;beta pleated sheet;Binding;Brain;calcium indicator;Calcium Signaling;Cells;Clinical Trials;Complex;Crossbreeding;Data;Detection;Diagnostic Imaging;glial activation;Image;imaging potential;imaging probe;in vivo;in vivo evaluation;Induced Neurons;Infection;Label;Lesion;Ligands;Link;LoxP-flanked allele;Mediating;Microglia;Modeling;Monitor;Morphology;mouse model;Mus;nanobodies;Neuronal Dysfunction;Neurons;novel;novel diagnostics;novel therapeutics;Pathogenesis;Pathologic;Pathology;Phagocytes;Positron-Emission Tomography;Proteins;Public Health;Publishing;Reporting;Research;response;Rest;Senile Plaques;Signal Transduction;small molecule;Specificity;Structure;tau aggregation;tau Proteins;tau-1;Tauopathies;Therapeutic;Time;Transgenic Mice;Transgenic Model;Transgenic Organisms;two-photon;Visualization

PROJECT_TITLE: Clearance and In Vivo Detection of Tau Pathology

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_NAME: NEW YORK GENOME CENTER

PHR: Project Narrative Single-cell genomic tools provide excellent opportunities to survey the gene regulatory programs during mammalian development. This proposal aims to develop both experimental and computational technologies for multi-modal single-cell analysis of epigenome and transcriptome from mammalian germ cells. The proposed project will not only provide novel technologies for analysis of cell-type-specific regulatory programs from complex tissues, but will also uncover the underlying principles controlling mammalian germ cell development.

PI_NAMEs: ZHU, CHENXU  (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Advisory Committees;Automobile Driving;Award;Binding;Biology;Brain;brain tissue;career;cell type;Cells;Chimeric Proteins;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;Complex;Computational Biology;Computing Methodologies;Coupling;Data;Data Set;Detection;Development;Disease;DNA Sequence;Epigenetic Process;epigenome;Focus Groups;Foundations;Funding;Future;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;gene regulatory network;Genes;Genetic;Genetic Transcription;Genome;genomic tools;Germ Cells;Goals;histone modification;improved;Individual;interdisciplinary approach;invention;Investigation;Joints;Lead;Maps;Mentors;Methods;Modality;Molecular;Molecular Analysis;Molecular Profiling;Monitor;multimodality;multiple omics;Mus;new technology;novel;Organism;Outcome;Performance;Phase;Phenotype;Population;Positioning Attribute;Postdoctoral Fellow;Procedures;Process;programs;Regulatory Element;Research;Research Personnel;Resolution;Risk;Running;single cell analysis;single cell genomics;Surveys;Technology;technology platform;Time;Tissues;tool;Training;transcription factor;transcriptome;virtual

PROJECT_TITLE: Studying the Mammalian Regulatory Circuits by Developing Single-cell Multi-omics Technologies


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Nutrition;Obesity;Prevention

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE Obesity produces a variety of adverse medical, economic and psychological consequences. Unfortunately, weight lost in lifestyle change programs is usually regained. This project will contribute to new insights about the reasons why, aiding in the development of new interventions to improve the durability of weight lost in lifestyle change programs for obesity.

PI_NAMEs: ALLISON, KELLY C;HAYES, MATTHEW R;LOWE, MICHAEL R (contact);ROBERTS, SUSAN B

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Address;Adipose tissue;advanced analytics;Affect;Appetite Stimulants;Basal metabolic rate;Behavior Therapy;Behavioral;biobank;Blood;Body Composition;Body mass index;Body Weight decreased;Brain;Cholecystokinin;connectome based predictive modeling;Control Groups;Corpus striatum structure;Cues;Data;data mining;Desire for food;Development;diabetes prevention program;Diet;Economics;Energy Metabolism;Exercise;Fasting;Fatty acid glycerol esters;feeding;follow up assessment;follow-up;Food;Functional Magnetic Resonance Imaging;Future;Gastric Emptying;ghrelin;glucagon-like peptide 1;Goals;group intervention;Hormonal;Hormones;improved;increased appetite;Individual;Individual Differences;Influentials;insight;Intervention;intervention participants;Leptin;Life Style;Maintenance;Measures;Medical;Metabolic;Metabolism;Methods;Modality;Modeling;Modification;multidisciplinary;multimodality;Muscle;neural;neuroimaging;Neurosecretory Systems;novel;Nutritional;Obesity;obesity treatment;Outcome Measure;Overweight;oxidation;Participant;Phase;Physiological;Physiological Adaptation;Planning Techniques;Process;programs;psychologic;Qualifying;Recording of previous events;recruit;Relapse;response;Rest;Source;success;Taste Perception;Techniques;Testing;Thermogenesis;Time;total energy expenditure;treatment program;videoconference;Weight;weight loss intervention;weight loss program;weight maintenance;Weights and Measures;Work

PROJECT_TITLE: Predicting Weight Regain Following Weight Loss Using Physiological Measures of Appetite and Energy Expenditure


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Sustained weight loss of 10% reduces the severity of many of the medical problems associated with obesity such as diabetes, heart disease, high blood pressure and fatty liver. However, weight loss causes changes in energy metabolism and hunger that cause many people to regain lost weight. This study is designed to identify the physiological and molecular bases for these changes in persons with overweight/obesity by detailed prospective analyses of metabolism and food intake in a one year period following 10% weight loss.

PI_NAMEs: GALLAGHER, DYMPNA ;LEIBEL, RUDOLPH L (contact);MAYER, LAUREL ES;ROSENBAUM, MICHAEL

PROJECT_TERMS: Accounting;Achievement;Adipocytes;Adipose tissue;Autonomic nervous system;base;Behavioral;Biochemical;Body Composition;Body fat;Body Weight;Body Weight decreased;Brain;Brain Diseases;Calibration;Catecholamines;Circadian Rhythms;Clinical;Communities;Complex;Consensus;Corpus striatum structure;Data;design;Development;Diabetes Mellitus;Dorsal;Dose;Dyslipidemias;Eating;Eating Behavior;Endocrine;endophenotype;energy balance;Energy Intake;Energy Metabolism;Environment;Environmental Impact;Epigenetic Process;Equation;Expenditure;Fatty Liver;Food;food environment;Functional Magnetic Resonance Imaging;Gene Expression;Health Care Costs;Heart Diseases;Home environment;Homeostasis;Human;Hunger;Hypertension;in vivo;Individual;Individual Differences;instrument;Intervention;Leptin;Life Style;Maintenance;Malignant Neoplasms;mathematical model;Measures;Mediating;Medical;Metabolic;Metabolism;metabolomics;Mitochondria;Molecular;Morbidity - disease rate;mortality;Muscle;nanoelectromechanical system;Neurosecretory Systems;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Obesity;Outcome;Overweight;Peptides;Peripheral Blood Mononuclear Cell;Persons;Phenotype;physiologic model;Physiological;Physiological Adaptation;Physiological Processes;Physiology;Plasma;Procedures;prospective;Prospective Studies;Protocols documentation;recidivism;Respiration;response;Role;SARS-CoV-2 infection;Severities;Site;Skeletal Muscle;skeletal tissue;Sleep;Standardization;success;Surveys;System;Task Performances;Thinness;Thyroid Gland;Time;Training;urinary;Weight;weight maintenance

PROJECT_TITLE: Predictors of Recidivism to Obesity in Weight-Reduced Individuals


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Networking and Information Technology R&D (NITRD);Palliative Care;Physical Activity;Prevention;Telehealth

ORG_CITY: Chicago

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative With a prevalence of 6.2 million people and 1 million new cases diagnosed each year, heart failure continues to be one of the most frequent principal diagnoses for hospitalization, and a leading cause of death in the United States. Many of these hospitalizations are the result of inadequate self-care manifested in patients with heart failure as nonadherence to treatment recommendations and healthy lifestyle behaviors (e.g., medication taking, low-sodium diet, symptoms monitoring, physical activity). This study addresses a critical gap in our understanding of the potential use of consumer mobile health technologies and individually tailored text messages to improve self-care adherence and reduce mortality and morbidity in patients with heart failure.

PI_NAMEs: KITSIOU, SPYROS  (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Accelerometer;Address;Adherence;African American population;Age;Behavior;Behavioral;Blood Pressure Monitors;Cardiac;Cardiovascular system;care seeking;Cause of Death;Cessation of life;Clinical;Communities;comorbidity;Congestive Heart Failure;connected health;Data;Death Rate;Devices;Diagnosis;Diet;digital health;Drug Prescriptions;Emergency department visit;Employment;Enrollment;Ethnic Origin;Event;expectation;Failure;feasibility testing;fitbit;Funding;geographic barrier;Health;Health behavior;health belief;Health Care Costs;health related quality of life;Health Services Accessibility;Health Technology;healthy lifestyle;Heart failure;Home;hospital readmission;Hospitalization;Hospitals;improved;improved outcome;Income;Individual;innovation;Insurance;Intervention;intervention delivery;intervention effect;Knowledge;Link;Maintenance;Measures;Mediating;Mental Depression;mHealth;Minority;Mobile Health Application;Modeling;Monitor;Morbidity - disease rate;mortality;mortality risk;Outcome;Partner in relationship;patient oriented;Patient Readmission;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Physical activity;pilot test;Population;post intervention;Prevalence;primary outcome;programs;Provider;Race;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Research;Risk Reduction;secondary outcome;Self Care;Self Efficacy;sensor;Shapes;skills;socioeconomic disadvantage;Socioeconomic Factors;socioeconomics;Sodium;Sodium-Restricted Diet;Symptoms;tailored text messaging;Technology;Telephone;Testing;text messaging intervention;theories;therapy design;Time;tool;treatment as usual;Treatment Efficacy;United States;United States National Institutes of Health;urinary;Urine;Weight

PROJECT_TITLE: iCardia4HF: A multi-component mHealth app and tailored text-messaging intervention to promote self-care adherence and improve outcomes in patients with chronic heart failure

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Health Services;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Cervical cancer (CC) remains a significant problem worldwide and women living with HIV (WWH) have higher rates than the general population. Women living with perinatally transmitted HIV (WWPHIV) seem to be especially vulnerable even if they have received the HPV vaccine. This study will examine HPV vaccine effectiveness and will examine several tests to see which ones are best to screen HPV vaccinated and unvaccinated WWH including WWH so that no woman with cancer will be missed and at the same time, to make sure there are few false positives tests (that is they have a positive test but no disease).

PI_NAMEs: MOSCICKI, ANNA-BARBARA  (contact)

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Adherence;adolescent woman;Adopted;Affect;Age;Age Years;Algorithms;Antibody titer measurement;antiretroviral therapy;Anus;Biological Assay;Biopsy;Cancer Burden;Cancer Control;cancer prevention;Cell Cycle;Cervical;Cervical Cancer Screening;Cervical Intraepithelial Neoplasia;Child;Childhood;Clinic Visits;Clinical;clinically relevant;cohort;Cohort Studies;Collection;Colposcopy;cost effectiveness;Country;Coupled;Cytology;Data;data management;Detection;Disease;DNA Methylation;Dose;Effectiveness;effectiveness evaluation;Enrollment;experience;FDA approved;General Population;Genotype;Goals;Histologic;HIV;HIV Infections;HPV negative;HPV screening;HPV-High Risk;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Human papillomavirus 18;immunocytochemistry;immunogenicity;Infection;Infrastructure;innovation;International;Malignant neoplasm of cervix uteri;Malignant Neoplasms;men who have sex with men;Methods;Methylation;Midlife women;novel;novel marker;Observational Study;Outcome;Pediatric HIV/AIDS Cohort Study;Performance;perinatal HIV;Perinatal transmission;Persons;Population;Predictive Value;Prevention strategy;prospective;Provider;Publishing;Reflex action;Reporting;Research Design;retention rate;Risk;Safety;Sampling;screening;Screening for cancer;sexual debut;Specificity;Specimen;Stains;Testing;Time;Triage;unvaccinated;Vaccinated;Vaccination;vaccination outcome;vaccine effectiveness;vaccine evaluation;vaccine immunogenicity;vaccine-induced antibodies;Vaccines;Vagina;Visit;Vulnerable Populations;Woman;women's clinical trial;Women's study;Work;World Health Organization;young woman

PROJECT_TITLE: Real-world effectiveness of HPV vaccine in women living with HIV and its impact on cervical cancer screening accuracies

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

PHR: Understanding the neural mechanisms underlying decision-making is important because patients with many psychiatric disorders make mal-adaptive decisions, impacting many cognitive executive functions, including emotion and mood regulation. This grant studies how neural representations in the hippocampus and prefrontal cortex mediate two types of decisions that commonly occur in everyday life but have rarely been examined in the laboratory: decisions in novel situations that rely on generalizing from past experience to the new one, and decisions that rely on being able to flexibly generate new responses to familiar stimuli. The mechanistic insight from these studies promises to be critical for understanding pathophysiological processes in a broad range of psychiatric disorders.

PI_NAMEs: FUSI, STEFANO ;SALZMAN, C. DANIEL (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Accounting;Address;Anterior;Architecture;Area;autoencoder;Behavior;Behavioral Paradigm;Brain;cingulate cortex;Code;Cognitive;Data;Decision Making;design;Dimensions;Electrophysiology (science);emotion regulation;Event;executive function;Exhibits;experience;flexibility;Generations;Geometry;Grant;high dimensionality;Hippocampus;insight;Laboratories;Learning;Life;Machine Learning;Maps;Measures;Mediating;Memory;Mental disorders;Modeling;Monkeys;mood regulation;neural;Neural Network Simulation;neuromechanism;Neurons;neurophysiology;novel;Outcome;Patients;Prefrontal Cortex;Probability;Process;Psychological reinforcement;recurrent neural network;response;Response to stimulus physiology;Reversal Learning;Role;scaffold;Sensory;statistics;Stimulus;Structure;Synaptic Transmission;Testing;Time;Training

PROJECT_TITLE: Neurophysiology underlying neural representations of value

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]