NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

ORG_STATE: CA

PHR: Narrative The project aims to provide a comprehensive understanding of the dynamic relationships among adult social connection (social isolation, loneliness, aloneliess), alcohol, cannabis, and other drug use by using novel multivariate latent growth models with structured residuals techniques and extending and expanding the largest longitudinal national probability study of adult (ages 30-80) personal networks and substance use to a total of eight years of annual data.

PI_NAMEs: POLLARD, MICHAEL SEAN (contact)

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: Accounting;Adult;Age;Age disparity;alcohol and other drug;alcohol consequences;Alcohol consumption;Alcoholic beverage heavy drinker;Alcohols;Anxiety;Behavior;binge drinking;Cannabis;Characteristics;Communities;COVID-19 pandemic;craving;Data;Data Set;design;deviant;Dimensions;Distress;drinking;Drug usage;ethnic minority;Ethnic Origin;experience;Family;Friends;Funding;Gender;Growth;Health behavior;improved;indexing;Individual;innovation;Lifting;Link;Literature;Loneliness;Longitudinal Studies;Measures;Mediating;Mental Depression;Mental Health;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;mortality risk;National Institute on Alcohol Abuse and Alcoholism;novel;Outcome;pandemic disease;Pathway interactions;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;physical conditioning;Play;Policies;Population;Populations at Risk;pre-pandemic;Prevention;Privacy;Probability;Race;racial minority;Relaxation;Reporting;Research;Residual state;Respondent;Role;Sampling;satisfaction;social;Social Controls;Social Distance;Social Environment;Social isolation;Social Network;social norm;social relationships;Social support;sociodemographics;Structure;substance use;Surgeon;Surveys;Techniques;Time;Well in self;Work;young adult

PROJECT_TITLE: Trajectories of Isolation and (A)Loneliness with AOD Use, 2019-2027: A National Egocentric Network Study of US Adults

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cocaine;Fentanyl Misuse and Addiction;Methamphetamine;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: COLLEGE PARK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: CHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative: Drug abuse and overdose results in hundreds of thousands of emergency room visits, hospital admissions, and deaths which imposes a large financial cost on the Unites States healthcare system. Guided by molecular modelling, we will synthesize novel water soluble and high affinity macrocyclic arene (prismarenes and pagodaarenes) and measure their binding affinity toward a panel of drugs of abuse (DOA) followed by in vitro and in vivo toxicology and finally in vivo efficacy studies to identify a lead in vivo supramolecular antidote for intoxication with DOAs. The project promises to impact human health by reducing the mortality and health care costs associated with DOA intoxication.

PI_NAMEs: ISAACS, LYLE D (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: adenylate kinase;Affinity;Amphetamines;Animals;Antidotes;aqueous;Basic Science;Binding;Binding Sites;Biological Assay;biological systems;biomaterial compatibility;Blood Circulation;Brain;Cations;Cell Death;Cessation of life;Chemicals;Clinical;Cocaine;cost;cost estimate;Crime;cytotoxicity;design;Designer Drugs;Development;Dimensions;Dose;driving force;Drug abuse;Drug Containers;drug development;Drug Kinetics;drug of abuse;ecstasy;efficacy study;Electrostatics;Emergency department visit;Emergency Situation;Epidemic;Esotropia;Evaluation;Federal Government;Feedback;Fentanyl;fentanyl abuse;fentanyl analog;Financial cost;Future;Hallucinogens;Health;Health Care Costs;Healthcare Systems;Hepatocyte;Heroin;Hospitalization;Human;Hydrophobicity;Illicit Drugs;In Vitro;in vitro Assay;in vitro testing;in vivo;in vivo evaluation;innovation;insight;Intervention;Intoxication;Investigational Drugs;Ions;Ketamine;kidney cell;Knowledge;Lead;Life;Location;Locomotion;Maximum Tolerated Dose;Measurement;Measures;mephedrone;Metabolic;Methamphetamine;microcalorimetry;Molecular;molecular modeling;mortality;Mus;Naloxone;Neurotransmitters;non-opioid analgesic;novel;Opioid;Opioid Antagonist;opioid overdose;Opioid Receptor;opioid use;Overdose;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Polyamines;prescription opioid;Process;Productivity;public health emergency;Reaction;Role;Route;Safety;Series;small molecule;Societies;Solubility;Stimulant;Structure;Symptoms;Testing;Titrations;Toxicology;Translating;United States;Variant;Water;water solubility;Work

PROJECT_TITLE: Macrocyclic Arenes as Sequestrants for Drugs of Abuse

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: RICHMOND

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF RICHMOND

ORG_STATE: VA

PHR: Project narrative: Tsetse-transmitted trypanosomiasis are a significant socioeconomic and health burden, imapcting millions of people in sub-Saharan Africa. Because a positive correlation exists between the density of tsetse’s facultative endosymbiont Sodalis glossinidius and the prevalence of trypanosome infection in tsetse’s midgut, a more complete understanding of the nature of the Sodalis-tsetse symbiosis will yield information to help control tsetse-borne disease. Furthermore, because Sodalis is one of only a few intracellular insect symbionts to be cultured outside of the host, it can be developed as a model for the study of other intracellular insect symbionts that have an impact on the ability of the insect to transmit disease.

PI_NAMEs: RUNYEN-JANECKY, LAURA JANE (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Africa South of the Sahara;African;Agar;Animals;Area;Arthropods;Bacteria;Biology;Blood;blood fractionation;Candidate Disease Gene;candidate identification;Communicable Diseases;Consumption;Defect;density;Disease;disease transmission;DNA amplification;DNA sequencing;Economic Burden;endosymbiont;Environment;Epidemiology;experience;Exposure to;feeding;fitness;fly;Frequencies;gene cloning;Gene Mutation;Generations;Genes;genetic manipulation;Genetic study;genomic locus;Goals;Growth;Health;health economics;Human;In Vitro;in vivo;Individual;Infection;Ingestion;Insecta;Investigation;Libraries;meetings;Methods;Midgut;Monitor;mutant;Mutate;Mutation;Native-Born;Nature;novel;null mutation;Nutrient;Outcome;pathogen;Periodicity;Persons;Phenotype;Physiological Processes;Plasmids;Poison;Prevalence;Proliferating;Sampling;socioeconomics;Study models;symbiont;Symbiosis;Testing;Time;Tissues;Toxic effect;trait;transmission process;transposon sequencing;Trypanosoma;Trypanosomiasis;Tsetse Flies;vector;Work

PROJECT_TITLE: Investigation of blood fitness genes in the tsetse fly symbiont Sodalis glossinidius

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: The adhesion of cells to extracellular matrix is fundamentally important for many physiological processes such as heart development, tissue regeneration, and wound healing. Such adhesion process is controlled by integrin- linked kinase (ILK) and it dysregulation has been linked to the progression of numerous diseases such as heart failure and stroke. Our proposal aims at determining the basic mechanism of the ILK function and its inhibitor development, which will not only help understand cell adhesion at normal and disease states of our body but also transform the diagnosis and treatment of ILK-mediated diseases.

PI_NAMEs: QIN, JUN  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Ablation;Actins;Address;adhesion process;Adhesions;Adhesives;Affect;AKT1 gene;Animal Model;Binding;Biochemical;Biology;Birth;Bundling;cardiogenesis;Catalysis;Cause of Death;Cell Adhesion;Cell model;cell motility;Cells;Communication;Complex;Cytoplasmic Tail;Cytoskeletal Modeling;Cytoskeleton;Data;Development;Diagnosis;differential expression;Disease;Drug Targeting;Enzymes;Event;Exclusion;Extracellular Matrix;Family;Focal Adhesions;Genetic;Goals;Guanine Nucleotide Exchange Factors;Heart failure;Human;human disease;improved;in vivo;inhibitor;Integrin beta Chains;integrin-linked kinase;Integrin-mediated Cell Adhesion Pathway;Integrins;kinase inhibitor;Learning;Life;Ligands;LIMS1 gene;Link;Malignant Neoplasms;mechanical force;mechanical signal;Mediating;Mediator;Membrane;MgATP;Microfilaments;migration;Molecular;Molecular Conformation;Monomeric GTP-Binding Proteins;Mus;Myocardial Infarction;Nature;novel;Pathway interactions;Phosphorylation;Phosphotransferases;Physiological Processes;Process;programs;protein complex;Proto-Oncogene Proteins c-akt;Publishing;receptor;recruit;regenerative healing;Role;scaffold;Shapes;Signal Pathway;Signal Transduction;Site;spatiotemporal;Stroke;tissue regeneration;Tissues;tool;transmission process;virtual;wound healing

PROJECT_TITLE: Molecular basis of ILK-mediated cell adhesion

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: SEATTLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Motivated by the fact that every possible single-’letter’ change in the human genome that is compatible with life already exists in someone alive today, the first phase of our Center for Multiplex Analysis of Phenotype (CMAP) sought to measure the effects of genetic variants on molecular and cellular phenotypes by developing technologies that have been used to measure the effect of ~11 million variants. However, meeting the promise of personalized genomic medicine must account for the fact that variant effects can depend on an individual’s unique life history beginning with development and laden with exposures to diverse environments, and that each individual variant exists in the context of millions of other variants. In the proposed second phase of our Center for Multiplex Analysis of Phenotype (CMAP) – we will develop technologies for mapping variant effects at scale across a wide range of environmental conditions, genetic contexts, and in multicellular model systems; and develop tools for forecasting individual disease risks. 1

PI_NAMEs: FOWLER, DOUGLAS M (contact);TRAPNELL, BRUCE COLSTON

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Accounting;Address;Algorithms;Animal Model;Atlases;Awareness;bench to bedside;Benign;Biological Models;Cell model;cell type;Cells;Classification;clinical encounter;cohort;computerized tools;Computing Methodologies;Data;Democracy;design;Development;Diagnosis;disorder risk;Education and Outreach;education planning;empowerment;Environment;Exposure to;Foundations;Genes;Genetic;genetic testing;genetic variant;Genome;genome sciences;genome sequencing;genome-wide;Genomics;Genotype;Goals;Human;Human Genetics;Human Genome;improved;Individual;induced pluripotent stem cell;Intervention;Knowledge;Lead;Letters;Life;life history;Maps;Measurement;Measures;Medical Genetics;meetings;Modeling;Modernization;Molecular;new technology;novel therapeutics;Nucleic Acid Regulatory Sequences;Organoids;Pathogenesis;Pathogenicity;Penetrance;personalized genomic medicine;Pharmaceutical Preparations;Phase;Phenotype;programs;Proteomics;response;Risk;Source;success;System;Technology;Tissues;tool;Training;trait;Variant;variant of interest;variant of unknown significance

PROJECT_TITLE: Technology to understand genetic variant effects in context

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Chronic Pain;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pain Research;Pediatric;Prevention;Rehabilitation;Sleep Research;Social Determinants of Health

ORG_CITY: PULLMAN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: Project Narrative PUBLIC HEALTH RELEVANCE: There is a remarkable increase in the incidence of chronic pain during the transition from early to middle adolescence, a developmental period that is also characterized by the heightened significance and salience of peer relationships and experiences on and offline. Although peer relationship difficulties are commonly observed in youth with chronic pain, whether these difficulties are a cause, correlate, or consequence of pediatric chronic pain is unknown. The long-term goal of this research program is to identify specific peer relationship processes (e.g., traditional and cyber-victimization, social support, and social connectedness) that influence pain persistence, exacerbation, and recovery in a cohort of youth at-risk for chronic pain, such that more developmentally appropriate and effective prevention and intervention programs can be created.

PI_NAMEs: FALES, JESSICA L (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Absenteeism;actigraphy;Acute Pain;Address;Adolescence;Adolescent;Adult;Affect;Age;anxiety symptoms;biobehavior;Child Development;Childhood;Chronic;chronic pain;Clinic;Clinical Practice Guideline;cohort;comorbidity;contextual factors;cost;cost estimate;Data;depressive symptoms;design;Development;diaries;disability;Disabling;Distress;effective intervention;effective therapy;Electronics;Elements;emotional distress;experience;Family;Friendships;Funding Opportunities;Goals;Headache;Health Expenditures;high risk;improved;Incidence;Individual;insight;Intervention;intervention program;Interview;Investigation;Knowledge;Link;Loneliness;Longitudinal cohort;Longitudinal Studies;media use;Mediating;medical specialties;Mental Health;Methodology;Methods;Modeling;Monitor;Moods;Musculoskeletal Pain;negative affect;novel;Outcome;Pain;pain outcome;pain symptom;pain-related disability;Pathway interactions;peer;peer victimization;Persistent pain;physical conditioning;poor sleep;Prevention;Prevention program;preventive intervention;Process;programs;prospective;protective factors;psychologic;Public Health;public health relevance;Recovery;Recurrent pain;Reporting;Research;Research Design;resilience;Risk;Risk Factors;Risk Reduction;Role;School Drop-Outs;Schools;Sleep;Sleep Disorders;Sleep disturbances;social;social anxiety;Social Environment;social exclusion;Social Functioning;Social isolation;social media;Social Processes;Social support;Student Dropouts;Study models;suicidal;Testing;therapy design;Time;Transact;Victimization;Youth

PROJECT_TITLE: Risk, Resilience, and Recovery: A Longitudinal Mixed-Method Study Examining the Role of Peer Relationships in Pediatric Pain

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Palliative Care;Physical Activity;Prevention;Women's Health Research

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE Women with metastatic breast cancer (MBC) treated with a CDK4/6 inhibitor exemplify a new and growing population of patients living long-term with metastatic cancer as a chronic and fatal condition (i.e., “metavivors”). In the current study, we will adapt an existing cognitive behavioral therapy intervention for fatigue (CBTF) for fatigued metavivors with MBC treated with a CDK4/6 inhibitor. We will then evaluate the feasibility, acceptability, and preliminary efficacy of the adapted intervention, called Energize-MBC, in preparation for a full-scale, multisite Phase II trial with high potential impact.

PI_NAMEs: JIM, HEATHER S.L. (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: Accelerometer;acceptability and feasibility;Accountability;actigraphy;Belief;Benchmarking;breast cancer diagnosis;Breast Cancer Patient;Cancer Center;Cancer Intervention;Cancer Patient;Cancer Survivor;CDK4 gene;Chronic;Chronic Disease;Chronic Myeloid Leukemia;Clinic;Clinical;Clinical Trials;Cognition;Cognitive Therapy;Community Clinical Oncology Program;Consultations;Data;Disease;Disseminated Malignant Neoplasm;efficacious intervention;Electronic Mail;Enrollment;Epidermal Growth Factor Receptor;Esthetics;Evaluation;Evidence based intervention;Exercise;Exercise Tolerance;exhaust;experience;Fatigue;feasibility testing;Feedback;follow-up;functional improvement;Future;Goals;Health Promotion;hormone receptor-positive;hormone therapy;Human;Immune checkpoint inhibitor;Impairment;improved;Individual;inhibitor;Intervention;Interview;Literature;Malignant Neoplasms;Melanoma patient;Metastatic breast cancer;Modafinil;Modification;novel therapeutics;Outcome;Palliative Care;Paroxetine;Participant;patient population;Patient Self-Report;Patients;Personal Satisfaction;Pharmacotherapy;Phase;phase II trial;phase III trial;Physical activity;Pilot Projects;pilot test;Placebos;Population;post intervention;Preparation;primary outcome;Protocols documentation;Provider;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;recruit;Research;response;Ritalin;satisfaction;secondary outcome;Sertraline;side effect;Site;Sleep;Structure;Supportive care;symptom management;Symptoms;targeted treatment;Telemedicine;Telephone;Terminal Disease;Testing;Text;Therapeutic Intervention;Time;treatment as usual;Treatment Efficacy;trial planning;usability;Waiting Lists;web platform;Woman;women's diagnosis;women's treatment

PROJECT_TITLE: Adaptation and Preliminary Evaluation of Energize-MBC: Cognitive Behavioral Therapy for Fatigue among Women with Metastatic Breast Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-J (J1)]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Osteoarthritis

ORG_CITY: MISSISSIPPI STATE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MISSISSIPPI STATE UNIVERSITY

ORG_STATE: MS

PHR: Project Narrative The goal of the proposed project is to develop a novel treatment for osteoarthritis based on slow release of a natural pomegranate derivative from polymeric microparticles that is formed upon injection of a polymer-oil emulsion into the knee joint. The treatment is intended to slow the progression of osteoarthritis by suppressing inflammation and thwarting the enzymes that destroy cartilage by inactivating them and decreasing their production. The project involves characterization of the drug’s anti-arthritic effects on human cells, optimization of the microparticle system formulation to achieve prolonged release of drug, and assessment of the drug delivery system’s safety.

PI_NAMEs: ELDER, STEVEN HOWARD (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: ADAMTS;Adrenal Cortex Hormones;Adult;Affect;Aliquot;anti-arthritic drug;aqueous;articular cartilage;Articular Range of Motion;Attention;Attenuated;biomaterial compatibility;bone;Cartilage;cartilage degradation;Cell Line;Cell model;Cells;Chondrocytes;chondroprotection;Collagen;collagenase 3;cytokine;cytotoxicity;Data;Degenerative polyarthritis;design;Development;Dialysis procedure;Diffusion;Disease;Disease Progression;Dose;drug candidate;Drug Delivery Systems;Drug Monitoring;Early treatment;Effectiveness;efficacy testing;Eicosanoids;Emulsions;Environment;Enzyme-Linked Immunosorbent Assay;Enzymes;Evaluation;experimental study;Exposure to;Extracellular Matrix;Formulation;Fruit;Functional disorder;Future;Goals;high risk;Human;Hyaluronic Acid;Hydroxyl Radical;In Situ;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Injections;innovation;Interleukin-1 beta;Interleukin-6;Intra-Articular Injections;Joints;Kinetics;Knee joint;Knowledge;lymphatic drainage;Macrophage;minimally invasive;Modeling;Morphology;novel;novel strategies;Oils;Osteoblasts;pain relief;Palliative Care;particle;Particle Size;Patients;Peptide Hydrolases;Peroxides;Pharmaceutical Preparations;Phase;Play;Polymers;polyphenol;Pomegranate;Porosity;Process;Production;prophylactic;proteinase In;punicalagin;Rattus;Reactive Oxygen Species;Research;response;Role;Route;S100A8 gene;Safety;Sesame Oil;Signal Pathway;Solvents;Stifle joint;Structure;Surface;System;Testing;Time;TNF gene;treatment duration;Variant;Water

PROJECT_TITLE: A novel approach to ultralong sustained delivery of punicalagin as a potential treatment for osteoarthritis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-Q (80)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Pediatric

ORG_CITY: FARGO

ORG_NAME: NORTH DAKOTA STATE UNIVERSITY

ORG_STATE: ND

PHR: Project Narrative One mission of the NICHD is to support basic research on typical human development. The proposed research examines a critical problem in early language learning: how children learn words with more than one meaning. These studies will test hypotheses of how children learn to associate multiple meanings with a single word when they are not specifically taught that a word has more than one meaning, which may have important implications for interventions and literacy.

PI_NAMEs: CONWELL, ERIN  (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Address;Basic Science;Categories;Child;Child Development;Child Support;contextual factors;coping;Cues;early childhood;Educational process of instructing;Face;Failure;Frequencies;Human Development;improved;insight;Intervention;Label;Language;Language Development;Learning;Learning Difficulty;lexical;literacy;Maps;Mission;Multilingualism;National Institute of Child Health and Human Development;novel;Only Child;prevent;Process;programs;Reading;Research;Research Support;response;Semantics;Source;Speech;syntax;Testing;theories;Uncertainty;Visual;Vocabulary;word learning

PROJECT_TITLE: Context and multiple meanings: Homophone learning in early childhood

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Bioengineering;Cancer;Colorectal Cancer;Digestive Diseases;Liver Disease;Nanotechnology;Natural Products

ORG_CITY: VERMILLION

ORG_NAME: UNIVERSITY OF SOUTH DAKOTA

ORG_STATE: SD

PHR: Public Health Relevance This study will develop a smart nanoparticle-based technology capable of unleashing the anti-cancer potential of veratridine, a plant-based molecule, at tumor sites. Understanding the fundamental mechanisms of veratridine will identify the contribution of tumorigenic pathways that selectively support tumor metastasis. This project can lead to the discovery of targeted therapies for primary and metastatic forms of CRC that is safer and more effective than current chemotherapies.

PI_NAMEs: REZVANI, KHOSROW SAMUEL (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: Adverse effects;Affinity;angiogenesis;Animal Experiments;Animals;anti-cancer;Anti-Hypertensive Agents;anticancer activity;Apoptosis;Applications Grants;Binding;Biological;Biological Assay;Camptothecin;cancer cell;cancer stem cell;Caseins;Cell division;Cell Line;cell motility;Cells;Characteristics;chemotherapy;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Colon;colon cancer patients;Colorectal Cancer;Complex;Data;Death Rate;Digestion;Disseminated Malignant Neoplasm;Drug resistance;Engineering;Enzymes;experimental study;Exposure to;FDA approved;Feedback;Fluorouracil;Genetic Transcription;Growth;high-throughput drug screening;Histologic;Hospitals;Human;human tissue;improved;In Vitro;inhibitor;interdisciplinary approach;Invaded;Knock-out;Liver;Liver neoplasms;Longitudinal Studies;LS174T colon cancer cell line;Malignant Neoplasms;Matrilysin;Matrix Metalloproteinases;Mediating;member;Metabolic;metastatic colorectal;Metastatic Neoplasm to the Liver;migration;Mitochondria;Mitochondrial Proteins;Molecular;mortalin;mouse model;multicatalytic endopeptidase complex;Mus;nanoparticle;nanoparticle delivery;Neoplasm Metastasis;neurotoxicity;Normal Cell;novel;novel therapeutic intervention;Oncogenic;Organ;Organoids;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;Plant Extracts;Plants;pre-clinical;Primary Neoplasm;Probability;Productivity;protein complex;Proteins;public health relevance;Rectum;Regulation;Role;Safety;Sampling;side effect;Signal Pathway;Silicon Dioxide;Site;stem cell fate;Survival Rate;targeted treatment;Technology;Therapeutic;therapeutic effectiveness;Tissues;tumor;tumor heterogeneity;Tumor Suppressor Proteins;tumorigenic;Ubiquitin;Ubiquitin Like Proteins;ultrasound;United States National Institutes of Health;Veratridine;Vinblastine

PROJECT_TITLE: "SMART" nanoparticle delivery of veratridine overcomes clinical challenges in metastatic colorectal cancer.

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-Z (J1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Mycobacterium tuberculosis (Mtb)- the causative agent of tuberculosis (TB)- is able to establish infection in the lungs, persist in humans for years, and kill more people than any other bacteria. The goal of this project is to determine whether Mtb infection alters host oxysterol metabolites, thereby modifying the host inflammatory response and promoting disease pathogenesis. These findings could lead to novel therapies and diagnostics for TB.

PI_NAMEs: PHILIPS, JENNIFER A (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Acids;adaptive immune response;adaptive immunity;Advanced Development;Africa;Asia;Bacteria;bacterial genetics;Biological Markers;Biological Process;biomarker development;C3HeB/FeJ Mouse;Carbon;Cholesterol;Cholesterol Oxidase;clinical care;cohort;data sharing;Diagnosis;Diagnostic;Disease;Disease Outcome;effective therapy;Enzymes;extracellular;Generations;Geography;Goals;Granuloma;Human;Hydroxysteroid Dehydrogenases;Immune;Immune response;Immune system;Immunity;immunoregulation;improved;in vivo;Individual;Infection;Inflammatory;Inflammatory Response;Innate Immune Response;insight;Knockout Mice;Knowledge Management Center;Lipids;Lung;Lung Diseases;Lymphoid;Lymphoid Cell;Macrophage;Mass Spectrum Analysis;metabolomics;Methodology;Modeling;Monitor;monocyte;mouse model;Mus;Mycobacterium tuberculosis;Myelogenous;Necrosis;neutrophil;novel;novel diagnostics;novel therapeutics;nutrition;Oryctolagus cuniculus;pathogen;Pathogenesis;Pathology;Patients;Persons;Phase;Phenotype;Plasma;Play;Positioning Attribute;Production;Pulmonary Inflammation;pulmonary symptom;response;Role;Sampling;Source;South America;Sputum;success;Symptoms;Tissues;transmission process;Tuberculosis;tuberculosis diagnostics;Vaccines;Work

PROJECT_TITLE: Defining host-pathogen oxysterol co-metabolites and their role in TB pathogenesis

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases;Lung

ORG_CITY: OXFORD

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MIAMI UNIVERSITY OXFORD

PHR: The proposed research is relevant to public health because current antibiotic therapy is poor at preventing chronic, long-term infection by the pathogen Mycoplasma pneumoniae. A deep understanding of M. pneumoniae biofilms, which are masses of bacteria that resist current drugs, is required to more effectively reduce disease caused by this common pathogen, including asthma and autoimmune diseases that result from chronic infection. This project is directly relevant to NIH’s mission in that part of the stated mission of NIH is to “foster fundamental creative discoveries, innovative research strategies, and their applications as a basis for ultimately protecting and improving health.”

PI_NAMEs: BALISH, MITCHELL F (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: acute symptom;Air;airway epithelium;alpha-glycerophosphoric acid;Animal Model;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Apical;Area;Asthma;Attenuated;attenuation;Autoimmune Diseases;Bacteria;Biological;Biomedical Research;Career Choice;Cells;Chronic;Chronic Disease;chronic infection;chronic respiratory disease;Clinical;Complement;Creativeness;Data;Detection;Development;Disease;Electrical Resistance;Elements;Environment;Enzymes;Epithelial Cells;Epithelium;experimental study;Fostering;Future;Gene Expression;Gene Expression Regulation;Genetic Transcription;Goals;graduate student;Growth;Health;human pathogen;Hydrogen Peroxide;Hypoxia;Immune response;improved;In Vitro;Infection;Inflammation;innovation;Intervention;Liquid substance;Maintenance;Measurement;Mediating;Medical;Microbial Biofilms;Microscopy;Mission;Modeling;Molecular;Morbidity - disease rate;Mucins;Mycoplasma pneumoniae;new therapeutic target;novel therapeutics;Outcome;Oxidases;Oxidative Stress;pathogen;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Pneumonia;preservation;prevent;Process;Production;Property;Proteins;Public Health;Research;residence;Resistance;Respiratory Tract Infections;response;Role;Scheme;Signal Transduction;Surface;Testing;Therapeutic Agents;therapeutic development;Tight Junctions;tissue culture;Tissue Culture Techniques;Toxin;Training;transcriptomics;translational impact;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Vaccines;Virulence;Virulence Factors;Work

PROJECT_TITLE: Causes and consequences of virulence factor attenuation in Mycoplasma pneumoniae biofilms


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cervical Cancer;Genetics;Human Genome;Infectious Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: SHREVEPORT

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: Human Papillomaviruses (HPV) infect keratinocytes in the skin and mucosa and induce tumors such as cervical carcinoma. Using a recently established infection model, we studied how HPV establishes infection. Studies proposed herein will focus on how infected cells maintain viral genomes and study the role of cellular pathways and viral oncoproteins in this process.

PI_NAMEs: ZWOLINSKA, KATARZYNA  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Apoptosis;Autophagocytosis;Cell Culture Techniques;Cell Cycle;Cell division;cell immortalization;Cell Line;Cells;Cervix Carcinoma;Chromosomes;Cytosol;Detection;DNA;DNA Damage;Event;Extracellular Matrix;Funding;G2 Phase;genetic analysis;Genetic Screening;Genome;Growth;Human papilloma virus 31;Human Papillomavirus;Human papillomavirus 16;Immune signaling;In Situ;Infection;keratinocyte;Knock-out;Knowledge;Licensing Factor;Life Cycle Stages;Maintenance;Mitosis;Mitotic Chromosome;Modeling;monolayer;Mucous Membrane;Mutation;Nuclear;Oncoproteins;Pathway interactions;Phase;Post-Translational Regulation;posttranscriptional;Preparation;prevent;Process;protein function;Proteins;Proteolytic Processing;Replication Initiation;response;RNA Splicing;Role;S phase;Signal Pathway;Signal Transduction;Skin;Stimulator of Interferon Genes;Stratum Basale;Supporting Cell;System;Testing;Textbooks;Time;Transcriptional Regulation;Translational Regulation;tumor;Viral;viral detection;Viral Genome;Virion;Virus;Virus Replication

PROJECT_TITLE: Immediate early events of the HPV life cycle

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LOUISVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative The goals of the KY INBRE are to build capacity for biomedical research and provide training to develop the research and healthcare workforce in the Commonwealth of Kentucky. These goals will lead to the improved diagnosis and treatment of human diseases.

PI_NAMEs: BICKFORD, MARTHA E (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Adherence;Award;Biomedical Research;Budgets;career;career development;college;Core Facility;course development;curriculum development;Data;Data Analyses;Data Science;Data Science Core;data sharing;Development;Diagnosis;Education;Ensure;Equipment;Evaluation;experience;Faculty;Faculty Recruitment;faculty research;Funding;Geography;Goals;Growth;Health;Healthcare;human disease;improved;infrastructure development;Institution;Kentucky;Laboratory Research;member;Mentors;Mission;Oranges;Privatization;Program Research Project Grants;programs;recruit;Recruitment Activity;Reporting;Research;Research Infrastructure;Research Personnel;Research Training;Science;skills;Students;Technology;Training;Training and Education;undergraduate research;undergraduate student;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: IDeA Networks of Biomedical Research Excellence in Kentucky

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-9 (IN)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Advisory Committees;Applications Grants;Biomedical Research;Budgets;career;career development;Collaborations;curriculum development;Data Science Core;Development;Education;Educational Curriculum;Educational workshop;Ensure;equipment acquisition;experience;Faculty;Faculty Recruitment;Financial Support;Funding;Geographic Distribution;Goals;high school;Home;Infrastructure;Institution;Joints;Kentucky;Laboratory Research;Leadership;Manuscripts;meetings;Mentors;Outcome;Peer Review;Peer Review Grants;Population;Postdoctoral Fellow;Program Research Project Grants;programs;Publications;recruit;Reporting;Research;research faculty;Research Infrastructure;Research Personnel;Research Support;Research Training;Resource Sharing;Science;Scientist;sound;student participation;Students;symposium;Teacher Professional Development;Training;undergraduate student;Universities;Work

PROJECT_TITLE: Administrative Core


PI_NAMEs: MATTINGLY, BRUCE A (contact)

PROJECT_TERMS: Applications Grants;Award;Biomedical Research;career;career development;Career Mobility;college;Core Facility;Data;Data Science;Data Science Core;Development;Discipline;Educational workshop;Eligibility Determination;experience;Faculty;faculty research;Funding;Funding Mechanisms;Goals;Grant;Guidelines;hands on research;Infrastructure;Institution;K-Series Research Career Programs;Kentucky;Mentors;Modeling;Pilot Projects;Preparation;Procedures;Process;Productivity;Program Research Project Grants;programs;Research;research and development;research faculty;Research Personnel;Research Project Grants;Research Support;Research Training;Services;Site Visit;Students;success;Training;training opportunity;Training Programs;undergraduate research experience;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities;Work;Workforce Development;Writing

PROJECT_TITLE: Developmental Research Project Program (DRPP)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: ROUCHKA, ERIC C (contact)

PROJECT_TERMS: Address;Applications Grants;Area;Artificial Intelligence;Bioinformatics;Biological Sciences;biomedical data science;Biomedical Research;Centers of Research Excellence;Cloud Computing;Computer software;Core Facility;Data Commons;data resource;Data Science;Data Science Core;Data Scientist;database of Genotypes and Phenotypes;design;Development;Educational workshop;Equipment;Experimental Designs;Faculty;Funding;Funding Mechanisms;Generations;Genome;genomic data;Genomics;Genotype-Tissue Expression Project;graduate student;Health Sciences;Hybrids;Image;Image Analysis;insight;Institution;interest;Kentucky;Machine Learning;Manuscripts;Methodology;Mission;nanopore;novel sequencing technology;Participant;Postdoctoral Fellow;Predictive Analytics;Preparation;Research;Research Personnel;Research Support;Research Training;Resources;Sampling;Schedule;sequencing platform;single cell sequencing;sound;Students;summer research;symposium;System;Teacher Professional Development;Technology;The Cancer Genome Atlas;Training;Training and Education;undergraduate student;Universities;voucher;Work

PROJECT_TITLE: Data Science Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

PI_NAMEs: ASHLEY, NOAH TODD (contact)

PROJECT_TERMS: Affect;Animal Experimentation;Animals;Award;Behavioral;biological research;Biological Sciences;Biology;Biomedical Research;Biotechnology;college;cost;Direct Costs;Educational Curriculum;Engineering;Equipment;Expenditure;Faculty;faculty support;Floor;Funding;Future;Future Teacher;Genetic;Grant;Institution;interest;Kentucky;member;Microbiology;Molecular Biology;Mus;Neurobiology;Neurosciences;Physiology;programs;recruit;Request for Proposals;Research;Research Personnel;Rodent Model;Science;Services;square foot;Students;System;Training;undergraduate student;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Alteration and Renovation


ADMINISTERING_IC: CK

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: Alpharetta

ORG_NAME: INTERNATIONAL SOCIETY OF TRAVEL MEDICINE

ORG_STATE: GA

PHR: GeoSentinel is a global surveillance network of travel and tropical medicine clinics, which has been highly productive in enhancing understanding of the epidemiology of imported infections and the detection of sentinel events related to emerging infections and infectious disease outbreaks. We collect data, using a standardized data collection form and uniform diagnostic criteria, on a broad variety of travelers and migrants during and after travel, in near-real time. We propose a wide-ranging series of research projects to further our understanding of travel-related illness and imported infections using our well-established surveillance platform.

PI_NAMEs: LIBMAN, MICHAEL  (contact)

PROJECT_TITLE: CK21-002 - GeoSentinel Database


ADMINISTERING_IC: TS

IC_NAME: AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY

ORG_CITY: ANN ARBOR

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed research will examine the mechanisms by which the gut bacteria of ALS patients alter the rate of disease through changes in metabolites or immune cells in the blood. The bacteria of the gut are a particularly attractive target for future therapies, as they can be easily and cheaply manipulated using existing interventions such as diet, probiotics, or fecal transplant. The proposed research will therefore have an immediate impact on potential ALS therapeutic strategies.

PI_NAMEs: MURDOCK, BENJAMIN JOSEPH (contact)

PROJECT_TITLE: RFA-TS-22-001: Interactions between the microbiome, metabolome, and immune system as underlying mechanisms of ALS pathogenesis


ADMINISTERING_IC: OH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: Chicago

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Overall Center – Project Narrative Agriculture is the most hazardous sector of the economy, and farmworkers experience the highest rate of severe illness, injury, and death in the U.S. In Illinois, 35-50,000 farmworkers live in extreme poverty and are profoundly disadvantaged, despite their critical importance to the food supply chain. The new Great Lakes Center for Farmworker Health and Wellbeing aims to collaboratively change systems to protect and promote the health and well-being of farmworkers through translation of basic science and survey research, surveillance, networking across NIOSH Centers of Excellence in Agriculture, Total Worker Health, and Education/Research, and outreach to workers, service providers, employers, trade organizations, government agencies and policymakers.

PI_NAMEs: FORST, LINDA S (contact)

PROJECT_TITLE: Great Lakes Center for Farmworker Health and Well-being


FUNDING_MECHANISM: OTHERS

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS STATE DEPT OF PUB HEALTH

ORG_STATE: MA

PHR: The Massachusetts Department of Public Health’s Occupational Health Surveillance Program (OHSP) is proposing to build on its extensive experience and network of partners to continue and enhance its Expanded Program for occupational health surveillance and prevention. The proposal contains focused surveillance and intervention systems for priority occupational health conditions and populations, collaborations with government and community partners to address identified problems, broad-based prevention activities based on surveillance findings, and integration of occupational health into mainstream public health practice. This proposal will contribute to foundational knowledge about the prevention and reduction of work- related injuries and illnesses using state occupational health surveillance programs.

PI_NAMEs: SPARER-FINE, EMILY HELEN (contact)

PROGRAM_OFFICER_NAME: O'NEILL, EDUARDO

PROJECT_TITLE: Expanded Occupational Health Surveillance in Massachusetts


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative A subset of leukemia and lymphomas, also called CD4+ T cells neoplasms, are rare and kill patients at a higher rate than other liquid tumors. New drugs, also called living drugs, manufactured from actual patients’ immune system cells, are increasingly being engineered and tested throughout the world. Specifically, so called T cells are taken out from the patients’ blood circulation, and genetically modified using a Chimeric Antigen Receptor, against the CD4+ molecule present in patients’ tumors. These so called CAR-T cells are then re-injected into patients and have the potential to attack and destroy recipients’ cancer cells throughout the body. With this study we propose to test this novel living drug against CD4+ tumors in patients with rare forms of leukemia or lymphoma for the first time, in a Phase I clinical trial aimed at documenting the maximum tolerated dose of such treatment and observe long term response. 1

PI_NAMEs: SALMAN, HUDA  (contact)

PROGRAM_OFFICER_NAME: KARP, JACQUELINE

PROJECT_TITLE: CD4 Redirected Chimeric Antigen Receptor T Cell Therapy for CD4 Positive T Cell Neoplasms


ORG_CITY: OLYMPIA

ORG_NAME: WASHINGTON STATE DEPT LAB & INDUST

PHR: Program Director/Principal Investigator (Last, First, Middle): Wuellner, Sara, E/Bonauto, David, K EXPANDED PROGRAM PROJECT NARRATIVE Through the systematic collection and analysis of data, the Washington Occupational Injury and Illness Surveillance program will provide relevant, timely, accurate public health data and information to those who can prevent hazardous exposures and improve safety and health in Washington's workplaces. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

PI_NAMEs: BONAUTO, DAVID K;WUELLNER, SARA  (contact)

PROJECT_TITLE: Washington Occupational Injury and Illness Surveillance Program


ORG_CITY: Trenton

ORG_NAME: NEW JERSEY STATE DEPT/HEALTH/SENIOR SRVS

ORG_STATE: NJ

PHR: Project Narrative New Jersey Department of Health (NJDOH) Fundamental Plus and Adult Blood Lead Occupational Health Surveillance Project Since 1985, the New Jersey Department of Health has conducted surveillance, funded by the National Institute for Occupational Safety and Health (NIOSH), for occupational illnesses and injuries which are reportable under New Jersey regulations that provides the Department with the authority to collect occupational health surveillance data. This proposal details our plans to i) expand on current traditional occupational data collection methods; ii) enhance unique state surveillance systems not traditionally used for occupational health and incorporate the collection of workplace information and iii) develop a framework for future emergent infectious diseases. This improvement of occupational health surveillance will allow for better targeted intervention of at-risk working populations and development of education and outreach materials.

PI_NAMEs: BORJAN, MARIJA  (contact)

PROJECT_TITLE: New Jersey Occupational Health Surveillance


ORG_CITY: COLUMBIA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: PROJECT NARRATIVE Amyotrophic lateral sclerosis (ALS) is a rare, fatal neurodegenerative disorder, with 90% sporadic cases do not have genetic causes and their contributing risk factors are largely unknown. The proposed work is exploratory and developmental in nature and will be one of the first pilot studies applying machine-learning-based, hypothesis-generating algorithms on statistically powerful real-world data to generate real-world evidence on ALS risk factors with or without an existing evidence base. The work will not only provide CDC agency of toxic substance and disease registry (ATSDR) with empirical evidence to better prioritize future decisions on expanding the ALS registry risk factor survey but serve to inform better designed proposals for future etiological studies and targeted trials for ALS.

PI_NAMEs: SONG, XING  (contact);STATLAND, JEFFREY

PROJECT_TITLE: RFA-TS-22-001:Towards Better Understanding of ALS using a Multi-Marker Discovery Approach from a Multi-Modal Database (ALS4M)


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Tuberculosis (TB) remains among the most deadly infections worldwide, especially among people living with HIV. Current available tests are not able to accurately detect persons at the highest risk of developing TB, and curing the disease requires at least 6 months of therapy because the TB bacteria can avoid being killed by the immune system and currently available drugs. In the current proposal, physician scientists will receive training in a variety of complementary disciplines, and use several cutting-edge experimental and modeling techniques to analyze samples from patients with TB and TB/HIV, with the ultimate goal of identifying new biomarkers that can predict TB disease and host-directed therapies that can shorten TB treatment.

PI_NAMEs: KARAKOUSIS, PETROS C (contact)

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: 5'-AMP-activated protein kinase;Address;Animal Model;Antibiotics;antimicrobial;Antimycobacterial Agents;Area;Attention;Automobile Driving;Bacteria;biobank;Bioinformatics;Biological Assay;biomarker identification;biosignature;career;Cause of Death;Chronic;chronic inflammatory disease;Clinical;Clinical Data;clinically relevant;cohort;Complex;cytokine;Development;Diagnosis;diagnostic tool;Discipline;Disease;Drug resistance;Environment;Foam Cells;Fostering;FRAP1 gene;Goals;high risk;HIV;HIV Seronegativity;HIV Seropositivity;HIV/TB;Homeostasis;Household;Human;Immune;Immune response;Immune system;Immunocompetent;immunoregulation;improved;indexing;Individual;Infection;International;Knowledge;Lesion;lifetime risk;Lipid-Laden Macrophage;Lipids;Lung Diseases;lung injury;Machine Learning;Macrophage;Medical;Mentors;Metabolic;Metabolism;MicroRNAs;Modeling;monocyte;multiplex assay;Mycobacterium tuberculosis;Necrosis;novel;Outcome;Participant;pathogen;Pathology;Pathway interactions;patient oriented research;Patients;peripheral blood;Persons;Pharmaceutical Preparations;Physicians;Population;Predisposition;prevent;Prevention;Preventive therapy;programs;progression risk;prospective;Proto-Oncogene Proteins c-akt;Pulmonary Tuberculosis;Regimen;Reporting;Research;Resources;Risk;risk prediction;sample archive;Sampling;Scientific Advances and Accomplishments;Scientist;Serum;Signs and Symptoms;Sirtuins;South African;Specimen;Systems Biology;Techniques;Testing;Tissues;Training;transcriptome;transcriptome sequencing;Triglycerides;Tuberculosis;tuberculosis granuloma;tuberculosis treatment;Validation;Whole Blood;Work;World Health Organization

PROJECT_TITLE: Mentoring in Immunometabolic Dysregulation in TB and TB/HIV

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Asthma;Health Effects of Indoor Air Pollution;Lung;Pediatric

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Asthma is more common in children than adults and persistence of childhood asthma has been conclusively linked to chronic lung function deficits that track into adult life. In a large study we reported for the first time that serum levels and whole blood gene expression of creatine kinase (CK) are decreased in childhood asthma, which suggests that CK may be a potential biomarker for early risk stratification of long-term persistence of childhood asthma. This proposal will investigate 3 areas of interest regarding the CK isoforms and asthma that will lead us down the path of further basic understanding, including: cell-specific expression levels, asthma- related mechanisms of CK regulation and the impact of low CK levels in early life on adult lung function using mouse models of asthma.

PI_NAMEs: LEDFORD, JULIE GUNNELLS (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Accounting;Address;Adult;Affect;Age;airway epithelium;airway hyperresponsiveness;allergic airway disease;Area;Asthma;asthma model;asthmatic;Biological Assay;Blood;Buffers;Cells;Child;Childhood;Childhood Asthma;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Circulation;Clinical Markers;cohort;Cohort Studies;Creatine;Creatine Kinase;cytokine;Data;Development;Diagnosis;Dose;Down-Regulation;early detection biomarkers;Elements;Environment;Enzymes;Epithelial Cells;experimental study;Future;Gene Expression;Heart;Homeostasis;House Dust Mite Allergens;Human;human data;Impairment;Inflammation;inhibitor;interest;Interleukin-13;Interleukin-6;Isoenzymes;Lead;Life;Link;long-term sequelae;Lung;Mitochondria;Morbidity - disease rate;mortality;mouse model;Mucins;Mucous body substance;mucus clearance;Mus;Muscle;Myocardial Infarction;Nasal Epithelium;Nature;Peptide Hydrolases;Persons;pharmacologic;Phase;Phenotype;Phosphocreatine;Play;Population;potential biomarker;predictive modeling;Predisposition;prevent;protective factors;Protein Isoforms;Puberty;Publishing;pulmonary function;Pyroglyphidae;Reaction;Regulation;Reporting;Research;resilience;Resolution;Respiratory System;Rhabdomyolysis;risk stratification;Role;Serum;Severities;Signal Transduction;Stat3 Signaling Pathway;Symptoms;Time;Tissues;translational study;United States;Whole Blood

PROJECT_TITLE: Determining the Role of Creatine Kinase in Asthma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RCCS-B(03)]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative The MYC family of oncogenes drive the development and progression of many human cancers. However, targeting MYC family oncogenes directly for cancer therapy has been unsuccessful so far. In this application, we will investigate a mRNA modification enzyme as a mediator of MYC action in cancer, which could be a druggable target for treatment of MYC-driven cancers.

PI_NAMEs: DING, HAN-FEI  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Address;Amino Acids;anti-cancer research;Award;base;Biological;biological adaptation to stress;Biological Models;Biological Process;cancer cell;Cancer cell line;Cancer Control;cancer therapy;Carbon;carcinogenesis;Cell Proliferation;Cell Reprogramming;Cells;Complement 5a;Development;dietary;druggable target;Enzymes;Epigenetic Process;epigenetic regulation;Event;Experimental Models;Family;Genetic Transcription;Glycine;Goals;Growth;Histone-Lysine N-Methyltransferase;Human;Hydrogen Bonding;Isomerism;knock-down;Link;Malignant Neoplasms;Mediating;Mediator;Messenger RNA;Metabolic;Metabolic Control;Metabolism;Modeling;Modification;Molecular;mRNA Stability;mRNA Translation;MYC gene;MYC-Family Oncogene;MYCN gene;new therapeutic target;novel;Oncogene Activation;programs;Proliferating;Pseudouridine;Publications;Regulation;Research;RNA;Role;Rotation;Serine;Signal Transduction;Site;stable isotope;Stress;Structure;sugar;targeted cancer therapy;Testing;Therapeutic;Transcription Coactivator;tumor;tumor metabolism;tumorigenesis;Uracil;Uridine

PROJECT_TITLE: RNA epigenetic regulation of cancer metabolism

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE This research is relevant to public health because children from minority and rural communities have the highest rates of obesity in the country, but they do not have easy access to the type of obesity treatment they need. This study will test whether adapting an obesity intervention for local communities improves the intervention’s reach to underserved communities and effectiveness at reducing obesity. By delivering this intervention in local community centers, we will build an intervention that could be used widely in communities across the country.

PI_NAMEs: HEERMAN, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: ILIAS, MALIHA R

PROJECT_TERMS: Address;Adoption;Age;American;arm;Attenuated;Behavior Therapy;Body mass index;Body Weight decreased;Child;Clinical;Cluster randomized trial;Communities;community building;community center;community intervention;community partnership;community setting;community-level factor;comparative effectiveness;Country;design;Development;Disparity population;Educational Curriculum;Effectiveness;effectiveness evaluation;effectiveness trial;efficacy trial;Ensure;evidence base;Evidence based intervention;Family;follow-up;Goals;Health;Health behavior;health inequalities;implementation outcomes;implementation process;implementation strategy;Improve Access;improved;indexing;Individual;innovation;Intervention;Low income;lower income families;Maintenance;Meta-Analysis;Minority;minority children;minority communities;Minority Groups;Mission;National Heart, Lung, and Blood Institute;Obesity;obesity in children;obesity treatment;Outcome;Parents;pediatrician;pilot test;Population;Process;programs;Protocols documentation;Public Health;Random Allocation;Randomized;Randomized, Controlled Trials;Readiness;recruit;Reduce health disparities;Research;Resources;Rural;Rural Community;Rural Population;Science;Site;social disparities;Social Environment;sociocultural determinant;Source;standard of care;Testing;theories;underserved community;Underserved Population;United States;Urban Community

PROJECT_TITLE: The ADAPT Trial: Adapting Evidence-Based Obesity Interventions in Community Settings

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cardiovascular;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: IRVINE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Continuous intracranial pressure (ICP) monitoring is considered one of the most important surveillance tools for neurological and neurosurgical patients that can provide critical insights on disease severity to guide medical and surgical management. However, the standard for continuous ICP monitoring, which entails drilling a burr hole into the skull and implanting an intracranial catheter or pressure sensor, is far too often not practiced due to its invasiveness and risks for infection, hemorrhage, and dislodgement. Continuous, non-invasive monitoring of the hemodynamic waveform at the carotid artery using soft, conformal sensors shows promise as an indirect means of continuously and non-invasively monitoring ICP.

PI_NAMEs: ABIRI, ARASH  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Algorithms;Aorta;Arteries;Blood Pressure;Brain;Caring;Carotid Arteries;Catheters;Cephalic;cerebral artery;Cerebral perfusion pressure;Cerebral Ventricles;Classification;Clinical;clinical practice;Clinical Protocols;cranium;Critical Illness;Data Analyses;Decision Making;Detection;Eligibility Determination;Excision;Exhibits;Future;Graph;hemodynamics;Hemorrhage;high risk;Hydrocephalus;Implant;indexing;Infection;infection risk;insight;Intensive Care Units;Intracranial Hemorrhages;Intracranial Hypertension;Intracranial Pressure;Investigation;Left;Measurement;Measures;Medical;Methods;Modeling;Monitor;Morbidity - disease rate;Morphologic artifacts;Morphology;mortality;Neurologic;Neurological status;neurosurgery;Noise;non-invasive monitor;novel;Operative Surgical Procedures;Parameter Estimation;Patient Admission;Patient Education;Patient-Focused Outcomes;Patients;Pattern;Peripheral;Physiologic pulse;Physiological;Population;pressure;pressure sensor;prevent;Procedures;prognostication;Proxy;Pulsatile Flow;Pulse Pressure;Radial;radial artery;Recommendation;Recovery;Resort;Risk;sensor;Severity of illness;signal processing;Signal Transduction;success;Surgical Management;System;TBI Patients;Technology;tool;Traumatic Brain Injury;Trephine hole;Validation;Work

PROJECT_TITLE: Non-Invasive Carotid Artery Measurements for Continuous Intracranial Pressure Monitoring

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-P(20)L]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

PHR: RELEVANCE (See instructions): Proper localization of viral components in cells is critical for efficient production of virus particles and spread from infected to uninfected cells. The goal of the proposed research is to elucidate the mechanisms that direct Gag, a structural protein of HIV-1 that causes AIDS, to the proper sites within virus-expressing cells. Knowledge obtained from proposed studies will help us develop novel antiviral strategies that may either directly suppress assembly and release of HIV-1 particles or inhibit spread of this virus to uninfected host cells

PI_NAMEs: ONO, AKIRA  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: 3-Dimensional;Ablation;Acquired Immunodeficiency Syndrome;Address;Affect;Binding;Biological Assay;CD44 gene;Cell membrane;Cell Proliferation;Cell surface;cell type;Cells;Collaborations;Complex;Cryoelectron Microscopy;Cytoplasm;Cytoplasmic Structures;Data;Environment;Event;experimental study;extracellular;follow-up;gag Gene Products;Genetic;Goals;HIV-1;Infection;Instruction;Integral Membrane Protein;Integration Host Factors;Intracellular Membranes;Knowledge;Lipids;lymph nodes;Macrophage;Mediating;Membrane;Membrane Lipids;Membrane Proteins;Messenger RNA;Microscopy;Molecular;Movement;Mutagenesis;N-terminal;nanodisk;novel;overexpression;P-selectin ligand protein;particle;Phospholipids;Plasmids;prevent;Process;Production;Proline-Specific tRNA;Property;recruit;Regulation;Research;Ribosomes;RNA;RNA Binding;Role;simulation;Site;spatial relationship;Stromal Cells;structural determinants;Structural Protein;Structure;superresolution microscopy;Surface;T-Lymphocyte;Testing;Transfection;Transfer RNA;Translating;Translations;transmission process;Viral;viral genomics;viral RNA;Viral Structural Proteins;Virion;virological synapse;Virus;Virus Assembly

PROJECT_TITLE: Mechanisms that determine subcellular sites of HIV-1 assembly

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AG

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Contraception/Reproduction

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Gametes are the basis for sexual reproduction, and it is thus important to the fitness of future generations that they are “reset” as young when generated, even if they originate from aged cells. The process by which gametes are created ensures that damaged contents from the precursor cell are not inherited by removing and replacing pre-existing components. We propose that by identifying the components that are cleared out during gamete resetting, and the mechanisms by which the cell removes them, we will better understand the cellular components that cause aging and uncover new strategies for combatting age-related cell damage.

PI_NAMEs: BRAR, GLORIA ANN (contact);JOVANOVIC, MARKO

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Age;age related;aged;Aging;Atlases;Biological Assay;cell age;Cell Aging;cell injury;Cell Physiology;cell type;Cells;Cellular Structures;Collaborations;combat;Complex;cost;Coupled;Data;Disease;Ensure;Excision;Exhibits;experience;extend lifespan;fitness;Functional disorder;Future Generations;Gametogenesis;Germ Cells;Goals;Housekeeping;Incidence;insight;interest;life span;Link;Mass Spectrum Analysis;Measurement;Measures;Meiosis;Mitotic;model organism;Molecular;molecular marker;Molecular Sieve Chromatography;multicatalytic endopeptidase complex;Organism;Outcome Study;oxidation;Pathway interactions;Physiologic pulse;Physiology;Population;portability;precursor cell;Predisposition;prevent;Process;Production;programs;protein aggregation;protein complex;protein degradation;protein function;Proteins;Proteome;Proteomics;proteostasis;Quality Control;Regulation;Rejuvenation;Ribosomes;Saccharomyces cerevisiae;Saccharomycetales;screening;Sexual Reproduction;Specificity;superoxide dismutase 1;Surveys;Testing;Time;transcription factor;transcriptome;Yeasts;Youth

PROJECT_TITLE: Defining the programmed proteome rejuvenation underlying gametogenesis

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Rare Diseases

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Abdominal aortic aneurysms (AAAs) are a life-threatening vascular disease responsible for over 15,000 deaths annually that are characterized by immune cells, namely macrophages, that contribute to pathological vascular remodeling. Our preliminary data demonstrate that epigenetic changes in macrophages, driven by JAK/STAT/SETDB2, regulate the activity of metalloproteinases, which function to break down the aortic wall and promote AAA formation. Using both murine models and human specimens, this proposal will seek to understand how these changes develop in aortic tissue and will test new therapies to restore macrophages to homeostasis and prevent AAA expansion.

PI_NAMEs: BAUER, TYLER MICHAEL (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Abdominal Aortic Aneurysm;Aneurysm;Aorta;Cells;Cessation of life;Chromatin;Clinical;Data;Data Analyses;Development;Elastases;Enzymes;Epigenetic Process;epigenetic regulation;Equilibrium;experimental study;Foundations;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;histone methylation;histone methyltransferase;Homeostasis;Human;Immune;immune cell infiltrate;in vivo;Infiltration;Inflammation;Inflammatory;insight;JAK1 gene;Life;Link;Lysine;Macrophage;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Mediating;Medical;Metalloproteases;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Myelogenous;Myeloid Cells;novel;novel therapeutics;Pathologic;Pathology;Pathway interactions;Patients;peripheral blood;pharmacologic;Phenotype;Play;prevent;Prevention;Process;Production;promoter;Regulation;Research Design;Role;Rupture;Scientist;Signal Pathway;Signal Transduction;Specimen;STAT3 gene;Surgeon;Surgical complication;Techniques;Testing;Therapeutic Agents;therapeutic target;TIMP1 gene;Tissue Inhibitor of Metalloproteinases;Tissues;Training;translational approach;Treatment Efficacy;Vascular Diseases;Vascular remodeling;Work

PROJECT_TITLE: SETDB2 regulates Abdominal Aortic Aneurysms


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: NARRATIVE The overall goal of the Comprehensive NeuroHIV Center (CNHC) is to develop, improve and sustain an infrastructure to provide services to a large number of scientists from the Philadelphia and beyone are who are involved in high impact research towards neuroHIV. CNHC offers unique expertise and services in gene editing strategies and delivery, cellular neurobiology and functional assessments and neuropsychological, virological and immunological data within a well-characterized and longitudinal clinical cohort. CNHC will provide pilot funding for junior investigators to enhance training and research for the next generation HIV scientists.

PI_NAMEs: KHALILI, KAMEL  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Achievement;Acute;Address;African American;Anti-Retroviral Agents;Area;Attention;base editing;Basic Science;Behavior Disorders;Behavioral;Biodistribution;Bioinformatics;Biological;Biometry;Black race;Brain;brain dysfunction;career;Cell Culture Techniques;Cells;Cellular biology;Cellular Neurobiology;Central Nervous System Diseases;Chronic Disease;Clinic;Clinical;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition Disorders;cohort;Collaborations;Communication;Communities;community based research;community partnership;Community Services;comorbidity;CRISPR/Cas technology;Data;data management;deep sequencing;design;Development;Discipline;Disease;Disease Progression;Disparity;DNA;Employment;Enrollment;Ensure;Equipment and supply inventories;Evaluation;experimental study;Face;Faculty;fitness;Flow Cytometry;Fostering;Funding;gene-editing approach;Genes;genetic approach;genome analysis;genome editing;Genomics;Goals;Grant;Guide RNA;health disparity;Hispanic;HIV;HIV-1;HIV-associated neurocognitive disorder;Homeostasis;Human;Human Resources;Image Analysis;immune function;Immunologics;Immunophenotyping;improved;In Vitro;Individual;Infection;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Laboratories;Leadership;Longitudinal cohort;Lymphoid Cell;lymphoid organ;meetings;member;Mental disorders;Mentorship;Methodology;Methods;microscopic imaging;Molecular;Molecular and Cellular Biology;Monitor;Myeloid Cells;National Institute of Mental Health;Nature;Needs Assessment;neuroAIDS;neurobehavioral;Neurocognitive;neurocognitive disorder;Neurons;neuropsychiatry;Neuropsychology;Neurosciences;new technology;next generation;Not Hispanic or Latino;novel strategies;operation;Organ;outreach;pandemic disease;Participant;patient oriented research;Patients;Performance;Periodicals;Peripheral;Persons;Pharmaceutical Preparations;Phenotype;Philadelphia;Physicians;Population;Preparation;prevent;programs;Progress Reports;Publications;quantitative imaging;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;RNA;Sampling;Science;scientific organization;Scientist;Secure;Services;side effect;Site;social;social determinants;stem;structural determinants;Surface;Technology;Tissues;Training;Translational Research;Underrepresented Minority;Update;Viral;viral DNA;Viral Genes;Viral Genome;Viral reservoir;Virus;Virus Diseases;virus genetics;Virus Replication;web site

PROJECT_TITLE: Comprehensive NeuroHIV Center


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Data Science;Lung;Prevention;Pulmonary Fibrosis;Rare Diseases;Tobacco;Tobacco Smoke and Health

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Idiopathic pulmonary fibrosis (IPF) is a progressive, smoking-related lung disease that has a poor prognosis; since current treatments slow future progression but do not reverse disease, there is an important need to identify and characterize the precursors of IPF. This proposal aims to use the radiomics signatures of chest computed tomography scans of smokers to stratify disease severity and to predict progression to early pulmonary fibrosis and advanced disease. Radiomics analyses may help identify patients at greatest risk for adverse events and most likely to benefit from early intervention to prevent the development of advanced IPF.

PI_NAMEs: CHOI, BINA  (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Advanced Development;advanced disease;adverse event risk;Advisory Committees;antifibrotic treatment;attenuation;automated image analysis;Big Data;Characteristics;chest computed tomography;Chest imaging;Clinical;cohort;Communication;Critical Care;Data;Data Science;density;Detection;Development;diagnostic value;Disease;Disease Progression;Disease stratification;Early Intervention;Exercise;Eye;Fibrosis;follow-up;functional outcomes;functional status;Future;Genetic;Goals;Grant;high risk;Histopathology;Hospitals;idiopathic pulmonary fibrosis;Image;improved;Inflammation;interest;interstitial;Interstitial Lung Diseases;Island;Laboratories;Lung;Lung Diseases;lung health;lung injury;machine learning algorithm;Manuscripts;Measurement;Measures;Medical Imaging;medical schools;Medicine;Mentors;Mentorship;Methods;microCT;mortality;novel;Oncology;Outcome;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Physicians;Preparation;prevent;Process;Prognosis;prognostic value;progression risk;protein biomarkers;Pulmonary Fibrosis;pulmonary function;Pulmonology;quantitative imaging;radiomics;Research;Risk;Scanning;Scientist;Severity of illness;Shapes;skills;Smoker;Smoking;smoking-related disease;smoking-related lung disease;Specificity;Spirometry;Stage at Diagnosis;Statistical Methods;statistics;Structure of parenchyma of lung;survival outcome;Teaching Hospitals;Texture;Time;tool;Training;tumor;Visit;Visual;Woman;Work;Writing;X-Ray Computed Tomography

PROJECT_TITLE: Radiomics Features of Quantitative Interstitial Abnormalities and Early Pulmonary Fibrosis


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Diabetes;Nutrition;Obesity;Prevention

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Gold-standard population treatment achieve SMARTer's Program intensive behavioral obesity treatments are not reaching the 2/3 of the U.S.  that needs to lose weight. Our resource-conserving, SMARTer stepped-care maximizes population impact by “rescuing” t reatment non-responders, so they clinically-meaningful weight loss. We propose a head-to-head comparison testing non-inferiority and cost-effectiveness relative to gold-standard, Diabetes Prevention and assessment only Control.

PI_NAMEs: SPRING, BONNIE  (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: adaptive intervention;Address;Adult;adult obesity;arm;Behavior Therapy;Behavioral;Body Weight decreased;Caring;Chronic Disease;Classification;Clinical;Cognitive;comparison control;cost;cost comparison;cost effective;cost effectiveness;craving;deprivation;design;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;Diet;Disinhibition;Eating;economic evaluation;effective intervention;efficacy testing;emotional eating;executive function;Expenditure;food insecurity;Future;head-to-head comparison;Health Care Costs;Heterogeneity;Individual;Intervention;literacy;Maintenance;Mediating;Mediator;Modeling;multiphase optimization strategy;negative affect;Neighborhoods;obese person;Obesity;Obesity Epidemic;obesity management;obesity treatment;optimism;Overweight;pandemic disease;Participant;patient response;Patients;Policies;Population;Population Programs;programs;Randomized;randomized, clinical trials;Randomized, Controlled Trials;relative effectiveness;Research;research clinical testing;Resources;response;restraint;Rewards;smartphone application;standard care;standard of care;Testing;Text Messaging;treatment as usual;Treatment Cost;treatment responders;treatment response;trial comparing;Weight;weight loss intervention

PROJECT_TITLE: SMARTer weight loss management

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Brain Disorders;HIV/AIDS;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

PROJECT_TERMS: Accountability;Acquired Immunodeficiency Syndrome;Affect;Area;Assessment tool;Award;Basic Science;Biological Assay;Biometry;Cataloging;Catalogs;cell behavior;Cell Line;Cells;Cellular Assay;Central Nervous System Viral Diseases;Cities;Clinic;Clinical;cohort;Collaborations;Collection;college;Communicable Diseases;Communication;community partners;community partnership;Country;Data;Data Analyses;Data Collection;Development;Disparity;Educational workshop;Ensure;Evaluation;Fostering;Funding;Genes;genetic analysis;Goals;graduate student;Grant;HIV;HIV-1;Image;Impairment;improved;Individual;induced pluripotent stem cell;Infrastructure;Institution;interest;International;Laboratory Research;Leadership;Learning;Measures;Medicine;Mental disorders;Mentorship;Microelectrodes;Microscopic;Mission;National Institute of Mental Health;Nervous System Disorder;neuroAIDS;neurobehavioral;Neurology;Neurons;Neurosciences;operation;Outcome;Participant;patient population;Performance;Persons;Philadelphia;Physicians;Play;Procedures;Process;Productivity;programs;recruit;Reporting;Research;Research Personnel;Research Support;Resources;response;Role;Rotation;Scientist;Self Assessment;Series;Societies;Source;Specimen;stem cells;Strategic Planning;Stress;symposium;synergism;Time;tool;United States National Institutes of Health;Universities;Update;Viral;Virus

PROJECT_TITLE: Administrative Core for Institution # 269291


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Social Determinants of Health

PI_NAMEs: BURDO, TRICIA HELEN (contact)

PROJECT_TERMS: Address;Aging;Area;Award;Basic Science;Behavior Disorders;Behavioral;Behavioral Research;Behavioral Sciences;Biological Assay;Brain;Cardiovascular system;career;career development;Cells;Clinical;Clinical Research;Clinical Sciences;cohort;Collaborations;college;Communities;comorbidity;Cost Sharing;design;Development;Discrimination;Disparity;Ensure;Evaluation;experience;Faculty;Feedback;Financial Support;Fostering;Functional disorder;Funding;Future;gender disparity;Genes;Goals;graduate student;Grant;high risk;HIV;HIV-1;immune activation;In Vitro;Infection;Infrastructure;innovation;Institution;interdisciplinary approach;interdisciplinary collaboration;Interpersonal Relations;Investigation;Leadership;Malignant Neoplasms;Manuscripts;Measures;medical schools;Medicine;member;Mental Depression;Mentors;Mentorship;Metabolic Activation;Microscopic;Minority Health Research;Mission;Molecular;multidisciplinary;National Institute of Mental Health;neuroAIDS;neurocognitive disorder;Neuropsychology;next generation;novel;novel therapeutics;outreach;pandemic disease;Performance;Persons;Pilot Projects;Play;Postdoctoral Fellow;Preparation;Process;programs;Progress Reports;Publishing;recruit;Reporting;Request for Applications;Research;Research Personnel;Research Priority;responsible research conduct;Review Committee;Role;Scientist;senior faculty;Services;sexual disparity;side effect;social;Social Sciences;social stigma;socioeconomic disparity;Strategic Planning;Structure;success;synergism;Testing;Time;Training;Underrepresented Minority;Universities;Work

PROJECT_TITLE: Component for Institution # 269291


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Genetics;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Social Determinants of Health

PI_NAMEs: WIGDAHL, BRIAN  (contact)

PROJECT_TERMS: Address;Aging;aging process;antiretroviral therapy;Area;Basic Science;Behavior Disorders;Behavioral;behavioral and social science;Bioinformatics;Biological;Biological Assay;Biological Markers;Black race;Cardiovascular system;career;Cell Line;Cell Separation;Cells;Cellular biology;Central Nervous System;Chronic;Clinical;Clinical Management;Clinical Research;co-infection;Cognitive;cohort;Collaborations;Communities;community partnership;comorbidity;daily functioning;Data;data management;Databases;design;Development;Disease;Disparity;Epidemiology;Evaluation;experience;Experimental Designs;Extramural Activities;falls;Flow Cytometry;Funding;Genes;Genetic;genome-wide;Genomic DNA;Genomics;Goals;Grant;Heterogeneity;Hispanic;HIV;HIV-1;Human Characteristics;Immune;immune activation;Immune response;Immunologic Factors;immunological status;Immunologics;Immunology procedure;Immunomodulators;Immunophenotyping;immunoregulation;Impairment;implementation science;improved;Individual;Infection;Inflammation;Informatics;Information Dissemination;Institution;Interdisciplinary Study;Investigation;Link;Longitudinal cohort;Malignant Neoplasms;Measures;Mental Depression;Mentorship;Metabolic Activation;Nature;neuroAIDS;neurobehavioral;Neurocognitive;Neurocognitive Deficit;neurocognitive disorder;Neuropsychology;next generation;next generation sequencing;Not Hispanic or Latino;novel therapeutics;pandemic disease;Participant;participant enrollment;Patients;Peripheral Blood Mononuclear Cell;Personal Satisfaction;Persons;Phenotype;Plasma;Population;prevent;Productivity;Proviruses;Reagent;recruit;Research;Research Design;Research Personnel;Research Priority;Research Support;Research Training;Resources;Role;Sampling;Scientist;sequencing platform;Services;side effect;social determinants;social factors;social health determinants;Social Sciences;structural determinants;Substance abuse problem;System;Technical Expertise;Time;Translational Research;Vaccines;Viral Genes;Viral reservoir;virus genetics;Virus Latency;Well in self;Work

PROJECT_TITLE: Clinical and Translational Research Support Core  for Institution # 269291


ADMINISTERING_IC: TR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project Narrative With this application, we propose to inspire and prepare a diverse set of professional students, including medical students and veterinarians, as well as PhD candidates in relevant biomedical disciplines, to devote their careers to clinical and translational science (CTS). These predoctoral scholars will enter the Tufts CTS Graduate Program to obtain a Certificate (one year), MS degree (two-year) or PhD degree. In addition to a general CTS track, we offer three specialized tracks: Predictive Analytics and Comparative Effectiveness Research (PACER), One Health, and Health Policy and Health Disparities (HPHD).

PI_NAMEs: KENT, DAVID M (contact)

PROGRAM_OFFICER_NAME: DIBELLO, ANTHONY THOMAS

PROJECT_TERMS: pre-doctoral;Universities

PROJECT_TITLE: CTSA Predoctoral T32 at Tufts University


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Social Determinants of Health

PI_NAMEs: BASS, SARAH B (contact)

PROJECT_TERMS: Address;Affect;antiretroviral therapy;Applications Grants;Awareness;Basic Science;Bioinformatics;care systems;Caring;Cellular biology;Clinical;Clinical Research;Communication;Communities;community empowerment;community engaged research;community engagement;community organizations;community partners;community partnership;comorbidity;Complement;Consultations;Continuity of Patient Care;cultural competence;Development;Discipline;Disease;Disparity;ethnic minority population;executive function;experience;Fostering;Friends;gender minority group;Goals;health disparity;health inequalities;Health Services;HIV;HIV diagnosis;HIV disparities;HIV/AIDS;Impairment;Inequity;Infection;Infrastructure;innovation;Institution;interdisciplinary collaboration;Intervention;Knowledge;Manuscripts;marginalized population;member;Memory;Mental Depression;Mentors;Mentorship;minority investigator;Needs Assessment;neuroAIDS;neurobehavioral;Neurobehavioral Manifestations;Neurocognitive;Neurocognitive Deficit;Participant;patient population;Persons;Population;Positioning Attribute;Poverty;prevent;Prevention;Publications;racial minority population;recruit;Research;Research Infrastructure;Research Personnel;Research Support;Resources;Risk;Science;Scientist;Services;sexual minority group;social determinants;social health determinants;social media;social service provider;social stigma;structural determinants;symposium;synergism;Time;Translating;Translational Research;treatment adherence;Twitter;Underrepresented Minority;Underrepresented Populations;Universities;Viral;Viral Genes;Viremia;web page;Work

PROJECT_TITLE: NeuroHIV and Community Partnership and Disparity Core for Institution # 269291


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Telehealth;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Cancer is the leading cause of death among Latinos, and among Latinas, breast cancer is the leading cause of cancer death. Latinas are a population at high risk of obesity, diabetes, and other cardiometabolic comorbidities, which are associated with poorer breast cancer outcomes. We will test adaptive interventions to identify the most effective multi-component home-based, online, culturally-tailored weight loss adaptive intervention in Latina breast cancer survivors.

PI_NAMEs: GREENLEE, HEATHER  (contact)

PROGRAM_OFFICER_NAME: AGURS-COLLINS, TANYA

PROJECT_TERMS: Accelerometer;Active Learning;adaptive intervention;Address;Aftercare;Area;behavior change;Behavior Therapy;Behavioral;bilingualism;Biological Markers;biopsychosocial;Blood;Body mass index;Body Weight decreased;Breast Cancer survivor;C-reactive protein;Cancer Etiology;cancer health disparity;Cancer Survivor;Cancer Survivorship;cardiometabolism;Cause of Death;Cessation of life;Characteristics;Cholesterol;comorbidity;compare effectiveness;contextual factors;County;Data;Data Collection;demographics;Devices;Diabetes Mellitus;diabetes prevention program;Diagnosis;Diet;dietary;Disease;Dryness;Education;effective intervention;Equity;evidence base;exercise intervention;experience;Geography;Glucose;Glycosylated hemoglobin A;Goals;Health;healthy weight;high risk;high risk population;Home;hormone therapy;improved;inclusion criteria;Individual;Inequity;Inflammatory;Intervention;Interview;Latina;Latina Population;Latino Population;learning strategy;Life;Los Angeles;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediator;Medical History;meetings;Mental Depression;Morbidity - disease rate;novel;nutrition;Obesity;Obesity associated disease;obesity risk;Outcome;Outcome Study;Overweight;Participant;patient oriented;Patients;Persons;Physical activity;Population;population based;Population Heterogeneity;programs;psychosocial;Quality of life;Questionnaires;Randomized;recruit;Recurrent disease;Registries;remote delivery;Reporting;Research;Resources;Sampling;Sequential Multiple Assignment Randomized Trial;Spanish/English;Spottings;Stress;Structure;success;Survivors;Technology;Telephone;telephone based;Testing;trial design;Triglycerides;Washington;web site;Weight;weight loss intervention;weight loss program;Weights and Measures;Woman;Work

PROJECT_TITLE: Using a SMART design to evaluate remotely delivered, culturally tailored weight loss interventions among Latina breast cancer survivors


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Project Narrative Research in neuroscience is crucial for attacking the causes of neurological and mental health disorders. If the field of neuroscience is to continue its rapid advance, neuroscientists must use, understand, and develop new technologies, acquire and analyze ever larger data sets, and grapple more directly with the complexity of neurobiological systems. The primary goal of this training program will be to help train the next generation of systems neuroscientists with the experimental and computational skills needed to make the discoveries of tomorrow.

PI_NAMEs: GITTIS, ARYN HILARY (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Big Data;Information Systems;Neurosciences;Training Programs

PROJECT_TITLE: Training Program in Big Data Systems Neuroscience


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Prevention

PROJECT_TERMS: Affect;Animal Model;Animals;Area;Award;Bioinformatics;bioinformatics pipeline;bioinformatics tool;Biology;Biomedical Research;Biometry;Blindness;Brain;cancer type;Cell Culture Techniques;Cell Line;Cells;Cellular biology;Clinical;Clinical Research;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;community partnership;cost effective;CRISPR/Cas technology;design;Development;Disease;Disparity;early detection biomarkers;Early Diagnosis;efficacy evaluation;Employment;Ensure;Excision;Familiarity;Gene Delivery;gene editing technology;Gene Expression;Gene Expression Regulation;gene-editing approach;Genes;Genetic;genetic approach;Genetic Transcription;Genome;genome editor;Genomics;Guide RNA;Hematological Disease;HIV;HIV Genome;HIV-1;Human Papillomavirus;humanized mouse;In Vitro;in vivo;Institution;Knowledge;Length;Literature;Mediating;Medicine;Mentorship;Modeling;Modernization;multidisciplinary;Mus;Mutation;Nervous System Physiology;neuroAIDS;Neurosciences;nonhuman primate;novel;novel strategies;Organ;Patients;Phase;Pilot Projects;pre-clinical;Productivity;programs;Rattus;receptor;Research;Research Personnel;Research Support;Resource Sharing;RNA Editing;Safety;Sequence Analysis;Services;Specificity;success;Techniques;Technology;Testing;Tissues;tool;Training;Translational Research;Universities;Viral;Viral Genes;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Viral Gene Editing and Bioinformatics Core for Institution # 269291


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;HIV/AIDS;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: SARIYER, ILKER KUDRET (contact)

PROJECT_TERMS: 3-Dimensional;Action Potentials;antiretroviral therapy;Area;Astrocytes;Award;Biological Assay;biomarker discovery;Blood Cells;Brain;brain cell;brain endothelial cell;Brain region;Cell Culture Techniques;Cell Line;Cell Physiology;Cell Survival;Cells;Cellular biology;Central Nervous System Diseases;Cerebrum;Clinical;Collaborations;combat;Data;data acquisition;design;Development;Disease;DNA;Electrophysiology (science);Endothelial Cells;Ensure;experimental study;Fluorescent in Situ Hybridization;Funding;genetic manipulation;Goals;Histologic;histological image;Histology;HIV;HIV-1;HIV-2;Human;human induced pluripotent stem cells;Image;Image Analysis;Imaging Techniques;Immune;In Vitro;in vivo;Individual;induced pluripotent stem cell;Infection;innovation;Institution;interest;Label;Macrophage;Maintenance;Mammalian Cell;Mentorship;Methods;Microelectrodes;Microglia;Microscopic;microscopic imaging;Microscopy;Mission;Modeling;Molecular;Morphology;multidisciplinary;nerve stem cell;neuroAIDS;neurocognitive disorder;Neurologic Deficit;Neurons;Neuropathogenesis;Neurosciences;Neurosphere;neurotransmission;neurotropic virus;novel;Oligodendroglia;Organoids;Patients;Physiological;Preparation;Primary Cell Cultures;Procedures;Process;Productivity;programs;Reagent;Regimen;Reproducibility;Research;Research Personnel;Resources;Rest;Risk;Scientist;Services;Site;SIV;spheroids;success;T-Lymphocyte;Technical Expertise;Techniques;Technology;Therapeutic;tissue processing;tool;Training;Translational Research;Viral;Viral Load result;viral rebound;Viral Vector;virtual;Virus;Virus Inhibitors;Virus Latency;Work

PROJECT_TITLE: Cell Biology and Functional Analysis Core for Institution # 269291


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Neurosciences;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE This is a competitive renewal application for a T32 training program to support training of Ph.D. students for careers in alcohol neuroscience research. Alcohol Use Disorder and Fetal Alcohol Spectrum Disorder are a major public health problem that is responsible for many illnesses, injuries, and deaths in the United States. Training more scientists to conduct alcohol research is essential to make progress and reduce the toll taken on public health.

PI_NAMEs: BRIGMAN, JONATHAN L (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TITLE: Alcohol Research Training in Neurosciences


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative The Duke University Program in Genetics and Genomics (UPGG) research training program aims to prepare predoctoral students for a variety of career paths in biomedical sciences. UPGG students perform genetics and genomics research contributing to the fundamental understanding of living systems as well as translational research that directly impacts the understanding of human health and disease. After graduation, our trainees will have the professional skills necessary to fill critical niches within the biomedical research field in academic institutions, private industry, and government agencies.

PI_NAMEs: ASHLEY-KOCH, ALLISON E (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Genetic;Genomics;Grant;Training

PROJECT_TITLE: Genetics and Genomics Training Grant

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: BOONE

ORG_NAME: APPALACHIAN STATE UNIVERSITY

PHR: The proposed research is relevant to public health because it addresses problems associated with nerve degeneration caused by injury or disease. The proposed project is relevant to the mission of the NINDS because it will provide fundamental knowledge about the gene regulatory mechanisms that promote successful nerve regeneration, which may ultimately be used to develop treatments for acute injury or neurodegenerative diseases of the central nervous system in humans.

PI_NAMEs: UDVADIA, AVA J (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Acute;Address;Adult;Automobile Driving;Axon;axon growth;axon regeneration;Biological Assay;cardiac regeneration;Central Nervous System Diseases;central nervous system injury;Chromatin;chromosome conformation capture;Data;deletion analysis;Development;digit regeneration;Disease;Distal;DNA Sequence;efficacy testing;Elements;Enhancers;experimental study;expression vector;Gene Expression;Gene Expression Profile;gene therapy;Gene Transduction Agent;Generations;Genes;Genetic Enhancer Element;Goals;Human;in vivo;in vivo Model;Injury;innovation;JUN gene;Knowledge;Link;Mammals;Maps;Mendelian disorder;Mission;Modeling;mouse model;National Institute of Neurological Disorders and Stroke;Natural regeneration;Nerve Degeneration;nerve injury;Nerve Regeneration;Neurodegenerative Disorders;Neurons;next generation;Optic Nerve Injuries;optic nerve regeneration;Outcome;Patients;Pattern;Physiological;prevent;programs;promoter;Promoter Regions;Public Health;Publishing;Recovery of Function;regenerative;Regulatory Element;Reporter Genes;Research;Risk;Safety;Screening procedure;Specificity;System;Testing;therapeutic gene;therapy design;Time;Toxic effect;transcription factor;Transgenic Organisms;Viral Genes;Work;Zebrafish

PROJECT_TITLE: Axon Regeneration-Associated Gene Enhancers Promoting Successful CNS Nerve Regeneration

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE This new University of Rochester IDDRC establishes the essential scientific Core infrastructure and administrative architecture to cohere the exceptional talents of 105 IDD investigators around five highly interlinked research cluster thematic foci, and articulates a clear purpose for our coordinated efforts – to serve persons with IDD to the best of our abilities, placing their interests at the heart of our research enterprise. Through a concerted effort across basic, translational and clinical investigators, we have set ourselves the clear goal of providing actionable clinical solutions for our IDD community. We will partner with our IDD community to communicate our work, and our passion, in a manner that is culturally competent, inclusive, and publically oriented.

PI_NAMEs: FOXE, JOHN J (contact);MAJEWSKA, ANNA K

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Acceleration;Adopted;Advisory Committees;Affect;Amalgam;Animal Behavior;Architecture;Area;Articulation;autism spectrum disorder;Automobile Driving;base;Basic Science;Biological;Biology;biopsychosocial;Brain;Caring;Catchment Area;cellular imaging;Child;Clinic;Clinical;clinical care;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Services;clinically actionable;Collaborations;college;Communication;Communities;Community Health Education;Community Outreach;Consultations;cost effectiveness;Counseling;cultural competence;Dedications;design;Development;Developmental Disabilities;Diagnostic Procedure;Disability research;Disease;early life exposure;Education and Outreach;Educational workshop;Ensure;ethnic diversity;Evaluation;expectation;Family;Fostering;Funding;Goals;Grant;health disparity;Health Personnel;Heart;Human;Individual;Infrastructure;innovation;insight;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Interdisciplinary Study;interest;Intervention;Leadership;lectures;Medical;Medical center;Medicine;Mind;Mission;Modeling;molecular imaging;Morals;Motion;Multilingualism;multisensory;neurodevelopment;neuroimaging;neuroinflammation;neurophysiology;Neurosciences;Neurosciences Research;next generation;novel diagnostics;Online Systems;operation;outreach;Pathologic;Pathway interactions;Patients;Pediatrics;Persons;Phenotype;Philosophy;Pilot Projects;Population;Positioning Attribute;prevent;professor;Program Sustainability;programs;Protocols documentation;Psychology;Publications;Quality Control;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;Scientist;service programs;Services;socioeconomics;Spielmeyer-Vogt Disease;Strategic Planning;Stress;success;Support Groups;System;Systems Integration;Talents;Technology;Therapeutic;Training;translational neuroscience;Translational Research;translational scientist;Universities;Vision;Work

PROJECT_TITLE: University of Rochester Intellectual and Developmental Disabilities Research Center