NIH_SPENDING_CATS: Asthma;Clinical Research;Eczema / Atopic Dermatitis;Infectious Diseases;Lung;Microbiome;Pediatric;Prevention

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease that affects 15-30% of children worldwide and predisposes to significant allergic comorbidities, including asthma, allergic rhinitis, and food allergy. A hallmark feature of AD is skin dysbiosis and increased prevalence of Staphylococcus aureus (SA); it is thus crucial to identify mechanisms of persistent microbial colonization in AD that may be targeted clinically for AD prevention and treatment. This proposal focuses on elucidating microbial patterns on AD skin and delineating the mechanisms of SA adhesion, invasion, and persistence over time in early life.

PI_NAMEs: DAHAL, ARYA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Adhesions;Adult;Affect;Agar;Air;Allergens;Allergic;Allergic rhinitis;anti-microbial peptide;antimicrobial;Asthma;Atopic Dermatitis;Attenuated;Automobile Driving;Bacteria;Binding;Biological;Blood;Candidate Disease Gene;Caring;Child;Childhood;Childhood Asthma;Chronic;Clinical;Clinical Data;clinically significant;Coculture Techniques;cohort;comorbidity;cytokine;Data;Development;Disease;DNA;Dryness;dysbiosis;Early Intervention;Eczema;Engineered skin;Exhibits;Family;filaggrin;Food;Food Hypersensitivity;Functional disorder;Future;Gene Cluster;Genes;genome sequencing;High Prevalence;Human;Immune;infancy;Inflammation;Inflammatory;Infrastructure;insight;Interleukin-13;Interleukin-4;Invaded;keratinocyte;Lesion;Life;Link;Lipoproteins;Liquid substance;Literature;Longitudinal Studies;loss of function mutation;Measures;Metagenomics;microbial;microbial colonization;microbiome;Morbidity - disease rate;mutant;Nature;new therapeutic target;novel;Outcome;Participant;Pathogenesis;Pattern;Positioning Attribute;Prevalence;prevent;Prevention;Production;prospective;Proteins;Public Health;Quality of life;Random Allocation;Recording of previous events;Relapse;Sampling;Severities;Severity of illness;Shotgun Sequencing;side effect;Site;Skin;skin barrier;skin disorder;skin lesion;Skin Substitutes;Specificity;Staphylococcus aureus;Structural Protein;Surface;Testing;therapy design;Time;Visit;whole genome

PROJECT_TITLE: Mechanisms of Longitudinal Microbial Colonization in Pediatric Atopic Dermatitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-C (20)]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Obesity and its comorbidities pose an ever-increasing challenge to public health despite existing therapies, highlighting the need for new therapeutic strategies. Increasing the amount of energy-burning brown adipose tissue in humans has the potential to reverse the caloric imbalance at the root of obesity, but there are major gaps in the current understanding of how brown adipose tissue develops. The studies performed as part of this fellowship will elucidate the cellular and molecular mechanisms underlying the development of brown adipose tissue, thus identifying new targets for therapeutic interventions.

PI_NAMEs: FEIN, ETHAN  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Adipocytes;Age;age related decline;Anatomy;Biological Assay;BMP7 gene;Brown Fat;Calories;candidate identification;career;Cell secretion;Cells;cellular targeting;Chemicals;clinical training;combat;comorbidity;Competence;Consumption;Data;Dermis;Dermomyotome;Development;Diabetes Mellitus;differentiation in vitro;Disease;Embryo;embryo tissue;embryonic stem cell;Encapsulated;Environment;Fatty acid glycerol esters;Fellowship;Fibroblasts;Fluorescence-Activated Cell Sorting;GATA6 transcription factor;Gene Expression Profile;Generations;Genes;Genetic Transcription;Goals;Health;Human;In Vitro;in vivo;Investments;Life Style;lipid biosynthesis;Maintenance;Measures;Medical;Mesoderm;Metabolic;metabolic rate;Modeling;Molecular;Molecular Target;Morphology;Mus;new therapeutic target;novel therapeutic intervention;Obesity;Operative Surgical Procedures;Organ;Pennsylvania;pharmacologic;Physicians;Physiological;Physiological Processes;Population;Prevalence;progenitor;Property;Public Health;Research Training;Rodent Model;Role;Scientist;Signal Pathway;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Skeletal Muscle;Sorting;Specific qualifier value;stem cell population;stem cells;Students;sugar;Tamoxifen;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Thermogenesis;tissue stem cells;Tissues;Training;Training Programs;transcription factor;Universities;Work

PROJECT_TITLE: Cellular and Molecular Mechanisms Underlying the Development of Brown Adipose Tissue

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-2 (O1)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Fragile X Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_DEPT: DENTISTRY

PHR: Project Narrative Fragile X syndrome (FXS), the most common form of heritable intellectual disability, is caused by the expansion of a CGG short tandem repeat (STR) at the FMR1 gene on chromosome X where local DNA methylation silences FMR1 expression. At the FMR1 locus and on multiple autosomes, we have recently found Megabase-scale H3K9me3 domains that form inter-chromosomal contacts in FXS. Using CRISPR/Cas9 engineering of the CGG STR, genomic assays and multimodal single nuclei-imaging, I will elucidate how expansion of the CGG STR at FMR1 spatially coordinates heterochromatinization and 3D genome miswiring.

PI_NAMEs: PHAM, KENNETH  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: 3-Dimensional;5' Untranslated Regions;autosome;Back;Biological Assay;CAG repeat;Cell Line;Cell Nucleus;Cells;CGG repeat;ChIP-seq;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Connective Tissue;CRISPR/Cas technology;Custom;Data;Data Engineering;Defect;Deposition;Disease;DNA;DNA Methylation;Engineering;Enzymes;Epithelium;Exhibits;experience;experimental study;FMR1 gene;Fragile X Syndrome;Frequencies;Functional disorder;Gene Expression;Gene Silencing;Genes;Genetic;Genome;Genomics;Heritability;Heterochromatin;Hi-C;histone modification;Image;Imaging Techniques;Immunofluorescence Immunologic;induced pluripotent stem cell;Intellectual functioning disability;Knockout Mice;Length;Location;Maintenance;Malignant Neoplasms;Measures;Mediating;Methods;Modeling;Modification;Multimodal Imaging;multimodality;Mutation;nanopore;overexpression;Pathogenicity;Pathologic;Patients;promoter;Protocols documentation;Quantitative Reverse Transcriptase PCR;RNA;Role;Short Tandem Repeat;Signal Transduction;single molecule;Symptoms;Synaptic plasticity;Tandem Repeat Sequences;Testing;Triplet Multiple Birth;Work;X Chromosome

PROJECT_TITLE: Elucidating the spatially coordinated mechanisms of transcriptional silencing in fragile X syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Single nucleotide polymorphisms (SNPs) in TMEM106B have been reported to alter risk of frontotemporal dementia, and TMEM106B protein aggregates were recently discovered in postmortem brains of individuals with FTD. This proposal aims to improve our understanding of how TMEM106B SNPs alter protein function, and to define disease-specific interactions of TMEM106B fibrils. Together, these data will inform the development of new therapeutic strategies and/or protein targets to combat FTD.

PI_NAMEs: MARKS, JORDAN DAVID (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Address;Affect;aged;Alleles;Alzheimer's disease related dementia;Amino Acids;Amyloid Fibrils;Antibodies;Autopsy;Behavioral;Biological;Biological Assay;Biological Models;Brain;brain control;Brain Pathology;causal variant;Cell Line;Cell model;Cell Physiology;Cells;Clinical;Code;cohort;combat;Data;Data Set;Development;Disease;disorder risk;Exhibits;Family;frontal lobe;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Functional disorder;genetic association;Genetic Complementation Test;Genetic study;GRN gene;Half-Life;Haplotypes;Healthcare Systems;Human;human disease;Immunoprecipitation;Impaired cognition;Impairment;improved;in vitro Model;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Integral Membrane Protein;knock-down;Knock-in;knockout animal;late endosome;Length;Light;Linkage Disequilibrium;Lysosomes;Minor;Modeling;Motor;Mus;Mutation;myelination;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;novel;novel therapeutic intervention;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Physiological;Positioning Attribute;Process;protein aggregation;protein degradation;protein function;protein protein interaction;protein TDP-43;Proteins;Proteomics;Publishing;Reporting;Risk;risk variant;Role;sarkosyl;Serine;Single Nucleotide Polymorphism;Synapses;targeted treatment;Testing;therapeutic development;Threonine;trafficking;United States National Institutes of Health;Validation;Variant;Western Blotting;Work

PROJECT_TITLE: The Role of TMEM106B in FTLD-TDP Pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-N (20)]


ORG_CITY: GAINESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative Type 1 Diabetes (T1D) is a metabolic disease that has recently been characterized as a disease of the whole pancreas, not just of insulin-producing β-cells. The goal of this proposal is to measure changes in energy metabolism in the exocrine pancreas within the context of T1D. The information gained from this work will provide unique insight into T1D pathophysiology and determine metabolic mechanisms underlying exocrine pancreas anomalies in T1D.

PI_NAMEs: RUSHIN, ANNA  (contact)

PROJECT_TERMS: Acinar Cell;Address;Adolescent;Adult;Affect;Age;Atrophic;Autoimmune;Autoimmune Diseases;Beta Cell;Biological Assay;Blood Glucose;Carbon;career;career development;cell type;Cellular Metabolic Process;Child;Citric Acid Cycle;Communication;Cytoplasm;Deposition;Development;Diabetes Mellitus;diabetes pathogenesis;Diabetic mouse;Disease;Duodenum;Endocrine;Energy Metabolism;Environment;Enzymes;ex vivo perfusion;Exocrine pancreas;experience;experimental study;Fatty acid glycerol esters;Fatty Acids;Fellowship;Fibroblasts;Fibrosis;Florida;Foundations;Functional disorder;Future;gastrointestinal symptom;Glycolysis;Goals;grasp;Heart;Histologic;Homeostasis;Hormone secretion;Hyperglycemia;improved;in vivo;in vivo Model;Infiltration;insight;Institution;Insulin;Insulin-Dependent Diabetes Mellitus;Investigation;islet;Islets of Langerhans;Knowledge;Laboratories;Link;lipid biosynthesis;lipid metabolism;Lipids;Liver;Magnetic Resonance;Malnutrition;Mass Fragmentography;Measures;Mediating;Mentors;Mentorship;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;metabolomics;Methods;Mitochondria;mitochondrial metabolism;Modeling;mouse model;neglect;NMR Spectroscopy;Nonesterified Fatty Acids;novel;Nuclear Magnetic Resonance;Organ;Pancreas;Patients;Perfusion;Peripheral Blood Mononuclear Cell;Persons;Physiology;Plasma;Process;Reporting;Research;Research Personnel;response;Role;skill acquisition;Spectrum Analysis;stable isotope;Structure;Structure of beta Cell of islet;Technical Expertise;Techniques;Testing;therapeutic target;therapy development;Tissues;Tracer;Training;Transgenic Mice;United States;Universities;Work

PROJECT_TITLE: Measuring Exocrine Pancreas Metabolism in Type 1 Diabetes


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Immunotherapy;Infectious Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Cytotoxic CD8 T cell responses are required for host protection against intracellular pathogens and cancers. Differentiation into memory cells is required for long-term protection as well as sustainable response to tumors. We will dissect the mechanisms by which cell-extrinsic stimuli through TCR and cytokine receptors shape the memory differentiation program at genetic and epigenetic levels.

PI_NAMEs: EGAWA, TAKESHI  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: activating transcription factor;Acute;Antigens;ATAC-seq;Binding;Binding Sites;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Immunity;Chromatin;chronic infection;Clonal Expansion;Clone Cells;CRISPR/Cas technology;cytokine;Cytokine Receptors;Cytokine Signaling;Cytomegalovirus Infections;cytotoxic CD8 T cells;DNA Methylation;effector T cell;Epigenetic Process;exhaust;Frequencies;gene regulatory network;Genes;Genetic;Goals;Grant;Human;Immune response;Immunotherapy;improved;In Vitro;Infection;insight;Interleukin 2 Receptor;Interleukin-15;Interleukin-2;IRF4 gene;Malignant Neoplasms;Mediating;Memory;Metabolic;Molecular;morphogens;Mus;Mutagenesis;pathogen;Process;Production;progenitor;programmed cell death protein 1;programs;promoter;Protein Isoforms;Receptor Signaling;Regulatory Element;Repression;response;Rest;self-renewal;Shapes;Signal Induction;Signal Transduction;Site;Stat5 protein;Stimulus;T cell differentiation;T cell response;T memory cell;T-Cell Activation;T-Cell Development;T-Lymphocyte;TCF Transcription Factor;Testing;transcription factor;Transcriptional Regulation;Transcriptional Silencer Elements;tumor;Vaccination;Viral;Virus Diseases;Virus Replication;XCL1 gene

PROJECT_TITLE: Molecular mechanisms of CD8 T cell fate decision instructed by cytokine signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (02)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Antimicrobial Resistance;Genetics;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE Malaria is a deadly parasitic disease that affects nearly half the world’s population. Unfortunately, drug resistance has been identified for all antimalarials in clinical use, which highlights an urgent need to design drugs that overcome resistance. This work aims to investigate a common mechanism of resistance in the malaria parasite in order to inform the development of antimalarials that circumvent drug resistance.

PI_NAMEs: BREMERS, EMILY KARA (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: ABCB1 gene;acquired drug resistance;Address;Affect;Anti-malarial drug resistance;Anti-malarials;Artemisinins;ATP-Binding Cassette Transporters;Azides;Biology;Cessation of life;Characteristics;Chemicals;chemoproteomics;chemotherapy;Clinical;Combined Modality Therapy;Copy Number Polymorphism;Cytosol;design;Development;Diazomethane;Disease;Drug Design;drug discovery;Drug Modulation;Drug resistance;drug sensitivity;Drug usage;experience;Fluorescence Microscopy;Gene Amplification;Gene Mutation;Genes;Genetic Polymorphism;Goals;Hemoglobin;improved;In Vitro;insight;knock-down;Knock-out;Libraries;Ligands;Lysosomes;Malaria;Mediating;Medicine;Mentorship;Molecular;Molecular Target;Mutation;new therapeutic target;novel;Organelles;Outcome;Parasite resistance;Parasites;Parasitic Diseases;Persons;Pharmaceutical Preparations;Plasmodium;Plasmodium falciparum;Population;Predisposition;prevent;Proteins;Proteomics;Pump;Qualifying;Regimen;Research;Research Personnel;Resistance;Resistance development;resistance mechanism;resistant strain;response;Scientist;screening;Single Nucleotide Polymorphism;Surface;Techniques;Testing;Training;undergraduate student;Universities;Vacuole;Validation;virtual;Work

PROJECT_TITLE: Understanding Plasmodium falciparum's multidrug resistance protein through the characterization of a novel antimalarial class.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


NIH_SPENDING_CATS: Kidney Disease;Prevention

ORG_CITY: CORAL GABLES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: The creation and maintenance of a vascular access to secure hemodialysis represents a challenge even to the most experienced nephrologist. The narrowing of blood vessels (stenosis) that give access to patient circulation remains a significant complication. It is estimated that every year, over $2 billion is expended in the maintenance of vascular access and its complication in the US alone. This study aims at identifying a new therapeutic to prevent the failure of the most common vascular access, the arteriovenous fistula. Outcomes from these studies may represent a breakthrough that will provide new therapeutic targets and strategies to improve vascular access dysfunction, reduce medical complications, and, ultimately, save lives.

PI_NAMEs: GUPTA, VINEET ;SHIU, YAN-TING E.;VAZQUEZ PADRON, ROBERTO IRENARDO (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Acceleration;Adaptor Signaling Protein;Adhesions;Agonist;American;Animal Model;Animals;Anti-Inflammatory Agents;Antiinflammatory Effect;Arteriovenous fistula;Attenuated;Biology;Blood flow;Blood Vessels;Cells;Circulation;comorbidity;Complication;Consensus;cytokine;Cytokine Gene;Data;design;Development;Dialysis procedure;Dissection;Drug usage;Economic Burden;Ecosystem;End stage renal failure;Endothelium;Enzymes;experience;Experimental Animal Model;Extravasation;Failure;Family;Family suidae;Fibrosis;Fistula;Functional disorder;gain of function;Gene Expression;Genetic;Goals;Growth;Growth Factor;healing;Hemodialysis;hemodynamics;Human;Hyperplasia;improved;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Response;innovation;Integrins;Leukocytes;Ligands;Limb structure;loss of function;Macrophage;Macrophage-1 Antigen;Maintenance;Mediating;medical complication;Microsurgery;Modality;monocyte;Mus;Myelogenous;nanofiber;new therapeutic target;NF-kappa B;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Outcome Study;Pathogenicity;Patients;pharmacologic;Physiologic arteriovenous anastomosis;Population;Postoperative Period;pre-clinical;Pre-Clinical Model;prevent;Procedures;Property;Publishing;receptor;receptor for advanced glycation endproducts;Research;response;Risk;Role;S100A8 gene;scaffold;Secure;Signal Transduction;src-Family Kinases;statistics;Stenosis;Surface;Techniques;Testing;Therapeutic;Tissues;Toxic effect;Transgenic Mice;Trauma;Ubiquitination;vascular injury;Veins;Venous

PROJECT_TITLE: Integrin Activation to Prevent Early Arteriovenous Fistula Failure in End-stage Renal Disease Patients

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Myc is a well-known oncogene that contributes to the evolution of many cancer subtypes, and its expression is associated with increased metastasis, resistance to therapy, and poor prognosis and survival outcomes. While it is known that high Myc levels markedly increase protein synthesis rates in cancer cells and activate associated cellular stress-response signaling, a comprehensive understanding of how Myc-driven high protein synthesis loads contributes to cellular stress in cancer remains underexplored. This proposal aims to provide critical insight into the effects of Myc overexpression on translational activity in cancer and subsequent stress signaling to help elucidate potential novel avenues for cancer therapy.

PI_NAMEs: SCHOLE, KATE  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Address;Affect;Apoptosis;Apoptotic;Automobile Driving;Biochemical;Biogenesis;biological adaptation to stress;Burkitt Lymphoma;cancer cell;Cancer Cell Growth;Cancer cell line;cancer subtypes;cancer therapy;carcinogenesis;Cell Death;cell growth;Cell Line;Cell Proliferation;Cell Size;Cells;Cellular Stress;Distress;DNA cassette;Event;Evolution;experimental study;Frequencies;Gene Amplification;Growth;Hyperactivity;Induction of Apoptosis;inhibitor;insight;Laboratories;Malignant Neoplasms;Maps;Measures;Mediating;member;Messenger RNA;Modeling;MYC gene;Neoplasm Metastasis;novel;novel therapeutic intervention;Oncogenes;overexpression;Pathway interactions;Peptide Initiation Factors;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Polyribosomes;polysome profiling;Predisposition;prevent;Prognosis;programs;Proliferating;Protein Biosynthesis;protein expression;Proteins;proteostasis loss;recruit;Regulation;Reporting;Resistance;response;Ribonucleases;Ribosomal Proteins;Ribosomal RNA;ribosome profiling;Ribosomes;Role;Signal Induction;Signal Transduction;Stress;Stress Response Signaling;stressor;survival outcome;Testing;Tetracyclines;Therapeutic Intervention;therapy resistant;Toxic effect;Transcript;transcription factor;Transducers;Translation Initiation;Translational Regulation;Translational Repression;Translations;tumorigenesis;Up-Regulation;Western Blotting;Work

PROJECT_TITLE: Defining protein translation dynamics in cancers with differential Myc expression


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Sleep Research;Substance Misuse

ORG_CITY: LEXINGTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE The orexin system is increasingly being recognized for its key role in motivation to engage in maladaptive behaviors, including alcohol self-administration, in preclinical models. No clinical neuroscience research has advanced these preclinical findings, limiting our ability to determine whether the orexin system also contributes to alcohol use in humans. The proposed research will fill that gap by determining how administration of an orexin antagonist, suvorexant, impacts motivation for alcohol and other abuse-related effects of alcohol.

PI_NAMEs: STOOPS, WILLIAM WALTON (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: Acute;Adaptive Behaviors;addiction;Affect;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol exposure;alcohol measurement;alcohol seeking behavior;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;American;antagonist;Area;Basic Science;Behavior;Cessation of life;Chronic;Clinical;Clinical Research;Cognitive;Dose;drug maintenance;drug of abuse;Eating;Economic Burden;Electroencephalography;Fatty acid glycerol esters;Food;Goals;Heart Rate;Human;hypocretin;Hypothalamic structure;Individual;interest;Laboratories;Laboratory Study;Lateral;Literature;Maintenance;maladaptive behavior;Measures;Motivation;Neurobiology;Neuropeptides;Neurosciences;Neurosciences Research;non-drug;Observational Study;Oral;Outcome;Peptides;Performance;Peripheral;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Physiological;Placebos;Play;Polysomnography;Population;pre-clinical;Pre-Clinical Model;pre-clinical research;preclinical study;Public Health;receptor;reinforcer;Research;response;Rewards;Role;Sampling;Schedule;Self Administration;Sleep;Sleep disturbances;sleep regulation;Study Subject;System;Task Performances;Testing;Time;Translating;Translations;transmission process;Withdrawal;Work

PROJECT_TITLE: Influence of Orexin Antagonism on Motivation for Alcohol

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Pulmonary Hypertension;Rare Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: NARRATIVE / RELEVANCE TO PUBLIC HEALTH  People who are born preterm have a higher risk of developing pulmonary hypertension (PH) and heart failure as adults than people who are born full term. Molecular and cellular mechanisms that trigger and promote this disease are poorly understood. Since preterm infants are often exposed to supplemental oxygen (hyperoxia), this project seeks to understand how hyperoxia at birth promotes PH in adults and test potential therapeutic interventions that could advance thinking in how to improve the health of people born preterm.

PI_NAMEs: O'REILLY, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Adult;Angiotensin II;Angiotensins;Automobile Driving;Birth;Blood capillaries;Blood flow;Blood Vessels;Bronchopulmonary Dysplasia;Cardiac Myocytes;Cardiovascular Diseases;Chronic;cohort;Compensation;Development;Disease;Endothelial Cells;Endothelium;Enzymes;Exposure to;extreme prematurity;Functional disorder;Genetic Transcription;Goals;Health;Heart;Heart Atrium;Heart failure;Heterozygote;high risk;Human;Hyperoxia;Hypertension;improved;inhibitor;Injury;Intervention;Knowledge;Label;Left;Left atrial structure;Left ventricular structure;Life;life span;Lung;lung microvascular endothelial cells;mimetics;Mitochondria;Molecular;mortality;mouse model;Mus;NADPH Oxidase;Neonatal;Neonatal Hyperoxic Injury;new epidemic;oxidation;Peptides;Peptidyl-Dipeptidase A;Pericytes;Persons;Phenotype;postnatal;pre-clinical;preclinical study;Premature Birth;Premature Infant;premature lungs;prevent;Production;Proliferating;Public Health;pulmonary arterial hypertension;Pulmonary Hypertension;Pulmonary veins;response;Risk;Role;Serum;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;SOD2 gene;Source;supplemental oxygen;Survivors;Testing;Therapeutic Intervention;Thinking;Time;transcriptome;Translating;United States;valsartan;Vascular remodeling;Wild Type Mouse

PROJECT_TITLE: Defining how neonatal hyperoxia causes pulmonary hypertension in adults

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE AIRE is required for maintaining tolerance in the thymus and periphery to prevent autoimmune diseases but can also play a detrimental role by dampening immune responses against cancer. While deletion of thymic AIRE expression has been shown to improve response to immunotherapy in certain cancers by allowing the development of autoreactive T cells, whether extrathymic AIRE expression is involved in regulating anti-tumor immune responses remains unknown. This proposal investigates the role of peripheral AIRE expression and tumor associated Aire-expressing cells in tumor progression and immunity with the ultimate goal of improving immunotherapy approaches for cancer treatment.

PI_NAMEs: ARVEDSON, MATTHEW  (contact)

PROJECT_TERMS: Ablation;anti-tumor immune response;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Autoimmune;Autoimmune Diseases;Autoimmunity;autoreactive T cell;Biological Assay;Breast Melanoma;California;cancer immunotherapy;Cancer Model;cancer therapy;career;CD8B1 gene;Cell Communication;cell type;Cells;Cellular biology;Colon Carcinoma;Computer Analysis;Cre driver;Cytometry;Cytotoxic T-Lymphocytes;Data;Data Set;Dendritic Cells;Dependence;Development;diphtheria toxin receptor;Environment;exhaustion;extend lifespan;Fellowship;fetal;Flow Cytometry;Funding;Gene Expression;Gene Expression Profile;gene function;Generations;Genetic;Genetic Transcription;Goals;Immune;immune checkpoint blockade;Immune Evasion;Immune response;Immune Targeting;Immunology;Immunotherapy;Implant;improved;in vivo;Infiltration;insight;Institution;Investigation;Knockout Mice;Laboratories;Lymphocyte;Malignant Breast Neoplasm;Malignant Neoplasms;MC38;Melanoma;Mentorship;Methods;Microscopy;Modeling;monocyte;mouse model;Mus;Myelogenous;Myeloid Cells;neoplastic cell;next generation;novel;Pathway interactions;patient subsets;Patients;Peripheral;peripheral tolerance;Phenotype;Play;Population;prevent;recruit;Regulator Genes;Reporter Genes;Research;research and development;Research Project Grants;Resistance;response;Role;San Francisco;secondary lymphoid organ;Signal Induction;Signal Transduction;single cell analysis;single-cell RNA sequencing;skills;Solid Neoplasm;Sorting;System;T cell response;T-Lymphocyte;targeted cancer therapy;Testing;Therapeutic;therapy resistant;Thymus Gland;Time;TNFSF11 gene;tool;Training;transcriptome sequencing;Transgenic Organisms;tumor;Tumor Burden;Tumor Escape;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages;Tumor-Derived;Universities;Work

PROJECT_TITLE: Elucidating the Role of AIRE and Tumor Associated Aire-expressing Cells in Tumor Growth and Immune Evasion

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: PROJECT NARRATIVE The differing rates of progression from Mild Cognitive Impairment (MCI) to Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD) in diverse populations have been previously attributed to factors related to clinical health outcomes, but never fully disentangled due to the diversity of diagnostic criteria of MCI. This research proposal aims to identify patients with MCI by applying computational and machine learning approaches to structured and unstructured clinical data sources, as well as quantify how clinical and neighborhood factors may affect the time to progression from MCI to AD/ADRD incidence. Ultimately, this project seeks to quantify how effects of place-based disadvantage on progression from MCI to AD/ADRD incidence may be mediated and/or exacerbated by cardiovascular disease risk factors.

PI_NAMEs: LIZARRAGA, SILVIA MIRAMONTES (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Affect;Age;Algorithms;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Attention;Blood Pressure;California;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular effects;cardiovascular risk factor;career;Characteristics;Clinic;Clinical;Clinical Data;Clinical Informatics;clinical risk;clinical translation;Code;cognitive change;cognitive function;cohort;Complex;Computerized Medical Record;Data;Data Set;Data Sources;Dementia;dementia risk;deprivation;Diagnosis;Diagnostic;diagnostic criteria;Diagnostic Specificity;Disadvantaged;Disparity population;Drug Prescriptions;electronic medical record system;Environment;Ethnic Origin;Evaluation;Exhibits;functional independence;Future;Glycosylated hemoglobin A;Goals;Health;health disparity;Heterogeneity;Impaired cognition;improved;Incidence;indexing;Individual;informatics tool;Information Systems;International Classification of Disease Codes;Joints;Learning;Link;Machine Learning;machine learning model;Measures;Mediating;Mediation;medical specialties;Mentors;Mentorship;Methods;mild cognitive impairment;Modeling;modifiable risk;Natural Language Processing;neighborhood disadvantage;Neighborhoods;Outcome;Outpatients;patient population;Patients;Persons;Phase;Phenotype;Population;Population Heterogeneity;Predictive Factor;preservation;prevent;Process;public health priorities;Qualifying;Quality of life;Race;racial diversity;Recruitment Activity;Research;Research Personnel;Research Proposals;residence;Resources;Risk Factors;Sampling;San Francisco;Selection Bias;sex;skill acquisition;skills;Smoking;social;social health determinants;Societal Factors;socioeconomics;Structure;structured data;support vector machine;Symptoms;Systematized Nomenclature of Medicine;Time;Training;translational scientist;Underrepresented Populations;Universities;unstructured clinical data;unstructured data;Validation;volunteer

PROJECT_TITLE: Evaluating social and clinical risk factors for the progression from Mild CognitiveImpairment to Alzheimer’s Disease and Related Dementias using Real World ClinicalData

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Cancer;Immunotherapy;Infectious Diseases;Prostate Cancer;Urologic Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Prostatitis and prostate cancer are highly prevalent among older men and are marked by immune infiltration of the prostate. As CD8+ T cells play key roles in controlling inflammation and tumor growth, understanding the mechanisms by which prostate-resident memory CD8+ T cells are formed and maintained in response to infection is critical to understanding prostate biology. The goal of this project is to define the mechanisms that control the establishment of tissue-resident T cells in the prostate, which will provide translational information pertaining to prostate inflammation, prostate tumorigenesis, and immunotherapy for prostate tumors.

PI_NAMEs: TAKEHARA, KENNIDY  (contact)

PROJECT_TERMS: Acute;acute infection;Adhesions;Affect;Androgen Receptor;Androgens;antigen-specific T cells;Bacterial Infections;Biology;Brain;career;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cessation of life;chemokine;Communication;Cues;cytokine;Data;Dependence;Development;Disease;Down-Regulation;effector T cell;Engineering;Environment;Environmental Risk Factor;Epithelium;Exposure to;female reproductive tract;Fluids and Secretions;Gene Expression;Generations;genetic manipulation;Genetic Transcription;Gland;Goals;Granzyme;Homeostasis;Homing;Human;Immune;immune cell infiltrate;Immune response;Immunity;Immunotherapy;improved;in vivo;Infection;Infection prevention;Inflammation;insight;Interferon Type II;Intestines;intraepithelial;Kidney;Kinetics;Link;Liver;Lung;Lymphocyte;Lymphocyte Function;Lymphocytic choriomeningitis virus;Lymphoid;Maintenance;male;Male Genital Organs;Malignant neoplasm of prostate;Malignant Neoplasms;Memory;men;metaplastic cell transformation;migration;Modeling;Molecular;Mus;novel;Nuclear;Nuclear Hormone Receptors;older men;Organism;Parabiosis;pathogen;pathogenic bacteria;pathogenic virus;Phenotype;Play;Population;prevent;Prevention;Production;programs;Prostate;prostate carcinogenesis;Prostatic Neoplasms;prostatitis;Receptor Signaling;recruit;Regulation;Research;Residencies;response;Role;Science;Scientist;Signal Transduction;Site;skills;Skin;Small Intestines;T memory cell;T-Lymphocyte;Techniques;Testing;Testosterone;Therapeutic;tissue resident memory T cell;Tissues;tool;trafficking;Training;transcription factor;Transforming Growth Factor beta;tumor growth;Tumor-Infiltrating Lymphocytes;tumorigenesis;Up-Regulation;urethral microbiome;Validation;Virus Diseases;Withdrawal;Work;Writing

PROJECT_TITLE: Understanding Prostate Resident Memory T Cells


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Infectious Diseases;Rare Diseases;Skin Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The transcriptional changes through which Merkel cell polyomavirus T-antigens (T-Ags) incite tumorigenesis and neuroendocrine reprogramming in Merkel cell carcinoma (MCC) are poorly elucidated but critical to understanding the biology, origin, and vulnerabilities of these tumors. I propose to leverage in vivo murine models of T-Ag mediated reprogramming to elucidate the mechanisms of how T-Ags drive reprogramming to the neuroendocrine lineage and interrogate the requirement for tumor suppressor dysfunction to promote the acquisition of neuroendocrine phenotypes associated with MCC. These studies will elucidate a currently obscure area of T-Ag and MCC biology and establish a foundation for further exploration of T-Ag mediated reprogramming mechanisms and therapeutic targets.

PI_NAMEs: WEBER, MADISON  (contact)

PROJECT_TERMS: Ablation;Address;Adult;Antigens;Apoptosis;Apoptotic;Appearance;Area;Articulation;ATAC-seq;Automobile Driving;Back;Biology;Cancer Biology;cancer genome;career;Cell Cycle;Cell Differentiation process;Cell Line;Cell Lineage;cell type;Cells;Chromatin;Coupled;Data;Enabling Factors;epidermal stem cell;Epidermis;Epigenetic Process;epigenomics;Etiology;Experimental Designs;experimental study;falls;Fetal Development;Flow Cytometry;Foundations;Functional disorder;Future;Gene Expression;Genes;Genetic;genetic manipulation;Genetic Transcription;Genomics;Growth;Hair follicle structure;Homeostasis;Human;Immunohistochemistry;in vivo;Incidence;insight;Institution;Knock-out;Laboratories;latent infection;Lesion;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;Merkel cell carcinoma;Merkel Cells;Modeling;Molecular;mouse model;Mus;Mutation;Mutation Detection;neoplastic cell;neuroendocrine differentiation;neuroendocrine phenotype;Neuroendocrine Tumors;Neurosecretory Systems;novel;Oncogenes;Phenocopy;Phenotype;Polyomavirus;Polyomavirus Infections;Population;Positioning Attribute;Postdoctoral Fellow;Production;progenitor;programs;Repression;Research;Retinoblastoma Protein;retinoblastoma tumor suppressor;Role;single cell ATAC-seq;single-cell RNA sequencing;Skin;Skin Cancer;Skin Malignancy;Small T Antigen;stem cell biomarkers;stem cells;synergism;Techniques;Testing;therapeutic target;Time;TP53 gene;Training;transcriptome;transcriptome sequencing;Transgenic Mice;tumor;Tumor Suppressor Proteins;Tumor-Derived;tumorigenesis;tumorigenic;Viral;Western Blotting

PROJECT_TITLE: Merkel cell polyomavirus T-Antigen mediated reprogramming in adult epidermis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09A-R (20)]


PHR: Project Narrative: As obligate intracellular pathogens, viruses must hijack cellular machinery to mediate infectious processes. This proposal combines molecular biological, biochemical, biophysical, and bioinformatic approaches to determine how human adenovirus (AdV) manipulates arginine methylation, a post-translational modification deposited by cellular protein arginine methyltransferases, to regulate host RNA-binding proteins and thus promote viral infection. Findings generated from this study will have significant implications for understanding the roles of arginine methylation during viral infections as well as how AdV hijacks host splicing machinery, therefore informing the use of AdV vectors as vaccine, gene therapy, and oncogenic therapy platforms.

PI_NAMEs: ABBOTT, AMBER  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Address;Adenovirus Infections;Adenovirus Vector;Adenoviruses;Affinity;Area;Arginine;Binding;Biochemical;Biochemistry;Bioinformatics;Biological;Biological Assay;Biological Models;Biology;biophysical techniques;Biophysics;Calorimetry;career;Cell Physiology;Charge;Clinical;Code;collaborative environment;Communities;Confocal Microscopy;crosslink;Cytoplasm;Data;demethylation;Deposition;DNA biosynthesis;DNA Viruses;Enzymes;Event;experimental study;Family;Fellowship;Future;Gastrointestinal Diseases;Gene Expression;gene therapy;Genes;Human;human pathogen;Immunoprecipitation;Infection;interest;Kinetics;Knowledge;Lead;Liquid Chromatography;Lysine;Measures;Mediating;Methylation;Microscopy;Modeling;Molecular;Molecular Biology;Molecular Cloning;Molecular Virology;mutant;Nature;Nonstructural Protein;novel;Nuclear;Nuclear Proteins;Oncogenic;pathogen;Pediatric Hospitals;Pennsylvania;Phenylalanine;Philadelphia;Plaque Assay;Porifera;Post-Translational Protein Processing;Principal Investigator;Process;Production;Productivity;Protein Analysis;protein expression;Protein Family;protein function;Protein Methylation;Protein-Arginine N-Methyltransferase;Proteins;Research;Respiratory Disease;response;RNA;RNA Binding;RNA methylation;RNA Processing;RNA Splicing;RNA-Binding Proteins;RNA-Protein Interaction;Role;Site-Directed Mutagenesis;skills;Substrate Interaction;Techniques;therapeutic target;Titrations;tool;Training;Transcript;Universities;Vaccines;Viral;Viral Genes;Virus;Virus Diseases;virus host interaction;Western Blotting

PROJECT_TITLE: Adenoviral manipulation of arginine methylation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-S (20)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Eczema / Atopic Dermatitis;Genetics;Human Genome;Infectious Diseases;Microbiome

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Staphylococcus sp. are essential members of the human skin microbiome. We seek to understand the mechanisms by which genetically diverse staphylococci isolated from human skin contribute to skin health and homeostasis.

PI_NAMEs: OH, JULIA  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: 3-Dimensional;Address;Affect;Aryl Hydrocarbon Receptor;Atopic Dermatitis;Biological Assay;Biology;Cell Communication;Cell Separation;cell type;Cells;Collection;commensal microbes;comparative genomics;Complement;Congenital ichthyosis;congenital immunodeficiency;CRISPR interference;Cutaneous;Data;Data Set;Disease;Eczema;Engineering;Epidermis;Exhibits;experimental study;Fibroblasts;follow-up;Fractionation;Gene Expression Profile;Genes;Genetic Transcription;Genetic Variation;Genus staphylococcus;Goals;Health;Homeostasis;Hour;Human;Immune system;Immunity;Immunohistochemistry;immunoregulation;Individual;Inflammatory;inflammatory milieu;intercellular communication;interest;Investigation;keratinocyte;knock-down;Maintenance;Mass Spectrum Analysis;Mediating;member;Metabolic;Metabolic Pathway;metabolomics;Microbe;microbial;microbiome;microbiota;Modeling;Molecular;Mucous Membrane;Natural Immunity;pathobiont;Pathogenicity;Pathway interactions;Patients;Population;Positioning Attribute;Process;Production;Proteomics;receptor-mediated signaling;repaired;Reporter;Reporting;response;Role;Shapes;Signal Pathway;single-cell RNA sequencing;Skin;skin barrier;skin disorder;skin microbiome;Specificity;Staphylococcus aureus;Staphylococcus epidermidis;Staphylococcus haemolyticus;Staphylococcus hominis;Surveys;Therapeutic;transcriptome sequencing;transcriptomics;Translating;whole genome

PROJECT_TITLE: Molecular mechanisms of staphylococcal modulation of skin homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-L (02)]


NIH_SPENDING_CATS: Burden of Illness;Clinical Research;Coronaviruses;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Social Determinants of Health

PHR: PROJECT NARRATIVE Financial toxicity is the objective financial burden or subjective financial strain resulting from treatment for illness. It is prevalent in many medical conditions, both acute and chronic, and in some conditions, like cancer, it is associated with worse outcomes, but its prevalence and risks in pneumonia are currently unknown. This project will use the Medical Expenditure Panel Survey to assess the prevalence of financial toxicity in survivors of pneumonia, and test the hypotheses that financial toxicity in these patients leads to (1) greater need for future care, and (2) increased disability.

PI_NAMEs: WOMER, JAMES W (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Acute Pneumonia;Acute respiratory failure;Address;Adherence;Affect;Ambulatory Care;American;Anxiety;Award;Cancer Patient;career;career development;Caring;Chest;Chronic;Clinical;clinical epidemiology;clinical investigation;cognitive function;Complex;cost;cost estimate;COVID-19 pandemic;COVID-19 patient;COVID-19 pneumonia;Critical Care;Data;Data Set;design;Development Plans;Diabetes Mellitus;disability;Disease;Dislocations;efficacy testing;Employment;Event;Expenditure;experience;Faculty;Financial Hardship;financial toxicity;Funding;Future;Goals;Grant;Growth;healing;Health;Health Care Costs;health economics;Health Expenditures;health related quality of life;Health Sciences;Health Services;Health Services Research;Healthcare;Hospitalization;Hospitals;Household;Impairment;improved;Individual;insight;Institution;Intervention;Investigation;K-Series Research Career Programs;Knowledge;Learning;Lung;Malignant Neoplasms;Manuscripts;Measures;Mediator;Medical;medical schools;Medicine;meetings;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Modeling;Morbidity - disease rate;Outcome;Outpatients;Patients;Peer Review;Physical Function;physical impairment;Physicians;Pneumonia;pneumonia treatment;predictive modeling;predictive tools;Prevalence;prospective;Public Health Schools;Publications;Publishing;PubMed;Quality of life;Recovery;Research;Research Personnel;respiratory;respiratory morbidity;Respiratory Signs and Symptoms;Respiratory Tract Infections;Review Literature;Risk;Sampling;Scientist;skills;Societies;statistics;stem;Surveys;Survivors;symposium;Techniques;Testing;Time;Training;Training Programs;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: The Association of Pneumonia-Related Financial Toxicity with Subsequent Outcomes


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: CHEMISTRY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE  New strategies are needed to chemically modify proteins through selective bioconjugation of specific amino acids, as well as unselectively through rapidly tagging amino acids for proximity labeling, as important information about protein structure and function, the design of new pharmaceutical products and targeted therapeutics, and disease microenvironments can be obtained. The proposed research describes the photocatalytic generation of reactive probes (2H-azirines, carbenes, and a-lactones) that can either label aspartic acid (Asp) and glutamic (Glu) selectively or undergo reaction with a variety of side chains for mapping cell surface microenvironments. This tool will ultimately improve public health by allowing modification of native proteins with greater precision and efficiency using low energy, tissue-penetrating red light.

PI_NAMEs: KARIOFILLIS, STAVROS KONSTANTINOS (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Affinity;Amino Acids;Antibody-drug conjugates;aqueous;Area;Aspartic Acid;Azides;Binding;Biochemical;Biological;Biological Assay;Biological Markers;biological systems;Biology;Biotinylation;Buffers;cancer cell;carbene;carboxylate;Catalysis;catalyst;Cell surface;Cell Survival;Cells;Chemicals;Chemistry;Collaborations;Complex;Cyclization;cytotoxicity;design;Development;diazo compound;Disease;Electron Transport;Employment;Energy Transfer;Engineering;Enzymes;Event;Foundations;Generations;Glutamic Acid;Goals;improved;In Situ;Investigation;irradiation;Label;Laboratories;Lactones;Libraries;Light;Maps;Mediating;Methods;Modeling;Modification;Nature;new technology;nitrene;novel therapeutics;nucleophilic addition;Osmium;Oxazoles;oxidation;Oxidation-Reduction;oxidative damage;Penetration;peptide drug;Peptides;Pharmaceutical Preparations;Pharmacologic Substance;Play;Post-Translational Protein Processing;Process;Production;Protein C;protein function;protein structure;Proteins;Proteomics;Public Health;Radial;Reaction;Reactive Oxygen Species;Reporting;Research;Role;Science;Series;Side;Site;small molecule;Sodium Chloride;spatiotemporal;Stimulus;Structure;Surface;System;targeted treatment;Technology;Therapeutic;Time;Tissues;tool;Translating;Triplet Multiple Birth;Tumor Antigens;Visible Radiation;Work

PROJECT_TITLE: Photocatalytic Generation of Reactive Probes for Bioconjugation and Proximity Labeling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Phosphoglucomutase I Deficiency, an inborn error of metabolism, was formerly classified as Glycogen Storage Disorder Type 14, although recent research demonstrated that it is also a Congenital Disorder of Glycosylation (CDG) with mixed glycosylation defects. Many aspects of the pathophysiology of the complex disease phenotypes, which include the therapy-resistant lethal dilated cardiomyopathy (DCM) remains unclear, despite oral galactose supplementation improves some other clinical symptoms. The long-term goals of this project are to employ cardiac-specific conditional Pgm2- knockout mouse model to (a) define the pathogenic mechanisms of the cardiac phenotypes; and (b) develop effective, safe and evidence-based therapies to address the unmet medical needs of the patients.

PI_NAMEs: BOUDINA, SIHEM ;LAI, KENT  (contact);MORAVA-KOZICZ, EVA

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: Address;Affect;Age;Aspartate;biglycan;Biochemical;Cardiac;Cardiac Myocytes;Cardiomyopathies;Citric Acid Cycle;Classification;Clinical;Co-Immunoprecipitations;Coagulation Process;Complex;Complication;Congenital disorders of glycosylation;Defect;Development;Dilated Cardiomyopathy;Disease;disease phenotype;Dystroglycan;early onset;Echocardiography;effective therapy;Endocrine;Energy Metabolism;Ensure;evidence base;Failure;Fiber;Fibroblasts;Frequencies;Functional disorder;Future;Galactose;Gene Delivery;gene replacement;Generations;Genes;genetic signature;Glucose;glucose 1 phosphate;Glucose-6-Phosphate;Glycogen;Glycogen Storage Disease;glycogenesis;glycogenolysis;Glycolysis;glycoproteomics;glycosylation;Goals;Heart;Heart Arrest;Heart Diseases;heart function;heart metabolism;Hemostatic Agents;Hormonal;Human;Hypoglycemia;Impairment;improved;in vivo;Inborn Errors of Metabolism;Individual;Inherited;insight;Integrins;Intermediate Filaments;Intervention;Knockout Mice;Laminin;Left;Left Ventricular Ejection Fraction;Left ventricular structure;Life;Liver;Liver diseases;liver function;Measures;Medical;Merosin;Metabolic;metabolic profile;metabolomics;Mitochondria;mitochondrial dysfunction;mouse model;Mus;Muscle;Muscle Cells;Mutation;Myofibrils;novel;novel therapeutics;Online Mendelian Inheritance In Man;Oral;Orthologous Gene;oxidation;Palmitates;Pathogenicity;Pathology;Patients;Phenotype;Play;Preparation;Production;Protein Glycosylation;Proteins;Research;Role;Sarcoglycans;Serum;Severities;Signal Transduction;Skin;Supplementation;Swelling;Symptoms;System;Testing;therapeutic evaluation;therapy resistant;Time;Tissues;Tracer;transcriptomics;Transferrin;Ventricular;α-Dystroglycan

PROJECT_TITLE: Pathobiological mechanisms of cardiac disease in PGM1-CDG

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Behavioral and Social Science;Diabetes;Neurosciences;Nutrition;Obesity

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Obesity and diabetes are a major epidemic in the United States and treated with pharmacotherapies targeting the glucagon-like peptide 1 receptor (GLP-1Rs). These drugs suppress appetite through their actions in the brain; however, a complete understanding of their mechanism of action in the brain is lacking. In this proposal, we will characterize the role of amygdala GLP-1Rs in regulating neuronal activity and as an anorexigenic target of GLP-1R agonists.

PI_NAMEs: DURAN, MIGUEL  (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: Adult;adult obesity;Agonist;American;Amygdaloid structure;Anatomy;Animal Feed;Anxiety;Attention;Automobile Driving;Behavior;Behavioral;Biology;blood glucose regulation;Brain;Cell Nucleus;Cessation of life;Clinical;comorbidity;Data;Desire for food;Devices;Diabetes Mellitus;Eating;effective therapy;Electrophysiology (science);Emotional;Energy Intake;Epidemic;experimental study;feeding;Fellowship;Fiber;Food;Fright;Future;Generations;Genetic;global health;GLP-I receptor;glucagon-like peptide 1;Goals;hindbrain;Hypothalamic structure;in vivo calcium imaging;Infusion procedures;insight;Insulin;Intervention;Label;Limbic System;Measures;Medial;Mediating;Methods;Molecular Mechanisms of Action;mortality;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;neural;Neurons;neuroregulation;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Optics;Output;Pancreas;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Photometry;Physiology;Population;Positive Valence;preclinical study;premature;Property;Publications;receptor;Receptor Activation;reduced food intake;Reporting;response;Rest;Risk Factors;Role;Site;Slice;System;Testing;Therapeutic;Time;Training;translational impact;United States;Weight;Weight maintenance regimen

PROJECT_TITLE: Assessing mechanistic relationships of central amygdala neuron activity and glucagon-like peptide-1 receptor agonism


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DAVIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE  The proposed project will identify the relationship of historical and contemporary residential segregation on cognitive aging and Alzheimer’s disease and related dementia in older adults. The project will provide insights on the role of education and poverty rates on the relationships between residential segregation and late-life cognitive decline and risk of Alzheimer’s disease and related dementia. Lastly, we will explore this relationship using neuroimaging biomarkers of hippocampal and whitter matter hyperintensities volume.

PI_NAMEs: LOR, YI  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Address;Adult;African American population;Age;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Area;Asian population;Biological Markers;Birth;Black Populations;Brain;brain health;California;career;Career Mobility;Censuses;Chronic Disease;Cognition;Cognitive;Cognitive aging;cohort;Cohort Studies;Communities;Data;Decision Making;dementia risk;Disparity;Distal;Education;Educational Status;Environment;Epidemiologist;Equity;ethnic diversity;Ethnic Origin;Ethnic Population;ethnoracial;Goals;Growth;Health;health disparity;healthy aging;high risk;Hippocampus;Hispanic;Hispanic Populations;Home;human old age (65+);Impaired cognition;improved;indexing;Individual;Inequity;insight;Institution;Institutional Racism;late life;Latinx;Latinx population;Lead;Life;Life Cycle Stages;Life Experience;Link;Longitudinal cohort study;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Mediating;Mediation;Methodology;middle age;minority communities;Modeling;neighborhood disadvantage;Neighborhoods;Nerve Degeneration;neuroimaging;neuroimaging marker;neurovascular;Not Hispanic or Latino;older adult;Outcome;Participant;Pattern;Policy Making;Population;Poverty;Prevalence;Productivity;protective factors;psychosocial;Race;racial diversity;racial population;Research;Research Personnel;residential segregation;resilience;Resources;Risk;Risk Factors;Role;segregation;skills;social;social health determinants;Structural Racism;Time;Training;Translational Research;underserved community;vascular injury;White Matter Hyperintensity

PROJECT_TITLE: Lifecourse Residential Segregation, Ethnic Enclaves and Risk and Resilience to ADRD in Diverse Cohorts


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Narrative If we want to understand how cells of the immune system, like B cells and T cells, can both protect from infections and cause damage in settings like organ transplant or autoimmunity, it is important to be able to follow the protective and damaging cells over time to see where they go, what they do and how long they live. The goal of this Program is to analyze the different types of B and T cells in samples of blood and biopsies from transplanted tissues that are collected multiple times over months to years from the same transplant patients. In the future, this information could be used to develop better treatments to eliminate the immune cells that cause damage in the organ without affecting the cells that protect us from infections.

PI_NAMEs: LUND, FRANCES E. (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Address;Affect;Antibodies;Antibody Response;antigen binding;Antigen Receptors;Antigens;Autoimmunity;B-Cell Antigen Receptor;B-Lymphocytes;Bioinformatics;biophysical analysis;Biophysics;Biopsy;Blood;Blood specimen;cell injury;Cell Lineage;Cell secretion;Cells;Chronic;Circulation;Clone Cells;Cloning;Complex;Cytoprotection;Data;data analysis pipeline;data integration;design;Development;donor-specific antibody;Endometrial;Endometrium;Environment;Evolution;Future;Generations;Goals;Homeostasis;Human;Immune;immune clearance;Immune response;Immune system;Immunoglobulin-Secreting Cells;Immunologic Memory;Immunology;immunoregulation;Individual;Infection;Inflammatory;Informatics;Kidney Transplantation;Knowledge;Learning;Location;Lung;Lung Transplantation;Lymphocyte;Lymphoid;Measures;Memory;Memory B-Lymphocyte;Modality;Monitor;Mucous Membrane;multidimensional data;Mus;Natural regeneration;Organ;Organ failure;organ transplant recipient;organ transplant rejection;Organ Transplantation;pathogen;Phenotype;Population;prevent;Production;programs;Property;Reagent;recruit;Research Project Grants;Residencies;Respiratory System;response;Sampling;Science;Services;Signal Transduction;Sorting;T memory cell;T-Lymphocyte;Time;tissue resident memory T cell;Tissue Transplantation;Tissues;tool;trafficking;Transplant Recipients;Uterus;Vaccination;Validation;Viral Proteins;Virus;Visualization

PROJECT_TITLE: Evolution and Durability of Human T and B Cell Responses

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 AM-I (J1)]


PROJECT_TERMS: Accounting;adaptive immune response;Address;American;Animals;Antigens;Authorization documentation;Autoimmunity;B-Lymphocytes;Blood;Blood specimen;Budgets;Cell Compartmentation;Cell Maintenance;Cells;Cellular biology;Collaborations;Communicable Diseases;Communication;Communities;Data;Dedications;Development;Disease;Endowment;Ensure;Event;Evolution;Expenditure;experience;Feedback;Financial Support;Fostering;Future;Generations;Goals;Grant;Human;Human Resources;human tissue;Immune;immune modulating agents;Immune system;Immunologic Memory;Immunologics;Immunologist;Immunology;Individual;interest;Investments;Kidney Transplantation;Knowledge;Learning;lecturer;lectures;longitudinal analysis;Lung;Lymphoid Tissue;Measures;Mediating;meetings;member;Memory;Memory B-Lymphocyte;Microbiology;Modality;Molecular;Monitor;Participant;pathogen;Pathogenicity;Peripheral;peripheral blood;Phenotype;Play;Policies;posters;prevent;Prevention;Process;programs;Progress Reports;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;response;Role;Rotation;Schedule;scientific organization;Scientist;Services;Shapes;Site;Stimulus;symposium;T cell response;T memory cell;T-Lymphocyte;Time;Tissue Sample;Tissues;Transplant Recipients;Transplantation;Travel;United States National Institutes of Health;Uterus;vaccine immunogenicity;Vaccine Research;Vaccines;Work

PROJECT_TITLE: Core A: Administrative Core


PI_NAMEs: KING, RODNEY GLENN (contact)

PROJECT_TERMS: Acceleration;Affinity;Alleles;Alloantigen;Antibodies;Antibody Affinity;Antibody Formation;antibody-mediated rejection;antigen binding;Antigen Receptors;Antigens;assay development;Autoantigens;B Cell Proliferation;B-Cell Antigen Receptor;B-Cell Receptor Binding;B-cell receptor repertoire sequencing;B-Lymphocytes;Binding;biophysical analysis;biophysical properties;Cell Compartmentation;Cells;Cessation of life;Clonal Expansion;Cloning;cross reactivity;Custom;Data;Data Analyses;design;Development;donor-specific antibody;Endowment;Enzymes;Evolution;expression vector;Flow Cytometry;Frequencies;Generations;Goals;graft failure;graft function;HLA Antigens;Human;Immune response;Immune system;Immunity;Immunoglobulin Class Switching;Immunoglobulin Isotypes;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;indexing;Individual;Informatics;instrumentation;Libraries;Ligation;Lymphocyte;Measurement;Monitor;Mutation;next generation;next generation sequencing;Organ Transplantation;pathogenic virus;Population;Process;Production;programs;Proliferating;Property;Quality Control;Reaction;Reagent;Receptor Gene;Recombinant Antibody;recruit;Research;Research Project Grants;Resources;response;Sampling;Serum;Services;Sorting;Specificity;Standardization;Structure;synergism;System;T-Lymphocyte;Technical Expertise;Techniques;Tissue Donors;Tissues;Transplant Recipients;Transplantation and Immune System;Validation;Viral;Visualization

PROJECT_TITLE: Core B: Antigen Receptor Sequencing, Cloning, Expression, and Analysis Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Organ Transplantation;Transplantation

PI_NAMEs: GREEN, TODD JASON (contact)

PROJECT_TERMS: Affinity;Affinity Chromatography;Alleles;Alloantigen;Allografting;Antibodies;Antibody Binding Sites;Antibody Formation;Antigens;B-Cell Antigen Receptor;B-Lymphocytes;Binding;biophysical analysis;biophysical properties;Biophysics;Biotinylation;Cell Lineage;Cell Separation;Cells;Clinical;Cloning;Collaborations;combat;Complex;Cryoelectron Microscopy;Data;donor-specific antibody;Epitopes;Evolution;experimental study;Flow Cytometry;Fluorochrome;Generations;Graft Survival;Heart;Histocompatibility Antigens Class I;HLA Antigens;Human;Immunoglobulin-Secreting Cells;Immunologist;Immunology;improved;Influenza;influenza virus strain;Injury;innovation;Kidney Diseases;Kidney Transplantation;Kinetics;Knowledge;Label;Lead;Libraries;life span;Light;Lung;Lung Diseases;Lymphocyte;Mass Spectrum Analysis;Mediating;Memory;Memory B-Lymphocyte;multidisciplinary;Organ;organ transplant rejection;Organ Transplantation;Outcome;Patients;Peptides;peripheral blood;Plasmids;polyclonal antibody;Production;programs;protein distribution;Proteins;Proteomics;Protocols documentation;Quality of life;Reagent;Recombinants;repository;Resolution;respiratory;response;Risk;Sampling;SARS-CoV-2 spike protein;Secure;Serum;Services;skills;Source;Specificity;structural biology;Structure;Surface Plasmon Resonance;synergism;T-Lymphocyte;Techniques;Therapeutic immunosuppression;Time;Tissues;tool;Translating;Transplant Recipients;Transplantation;United States National Institutes of Health;Validation;Viral;Viral Antigens;Work;X-Ray Crystallography

PROJECT_TITLE: Core C: Immuno-Reagent Production, Validation, and Biophysical Analysis Core


NIH_SPENDING_CATS: Clinical Research;Coronaviruses;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: ROSENBERG, ALEXANDER  (contact)

PROJECT_TERMS: Address;Allogenic;Antibodies;Antigen Receptors;Antigens;Area;Autoantibodies;B-cell receptor repertoire sequencing;B-Lymphocytes;Bar Codes;Bioinformatics;Biological Assay;Biometry;biophysical analysis;Cell Separation;Cells;Clinical;Clinical Data;Cloning;Collaborations;complex data;Computer software;computerized data processing;Consumption;Data;Data Analyses;data analysis pipeline;Data Analytics;data hub;data integration;data management;data pipeline;data quality;Data Reporting;Data Set;data sharing;data standards;Deposition;Documentation;Elements;Environment;Evolution;experience;experimental study;FAIR principles;Flow Cytometry;Gene Expression;Genetic Transcription;Genomics;Goals;health record;Human;Human Characteristics;Human Resources;Immune;Immune response;Immunology procedure;Individual;Informatics;Infrastructure;Investigation;large datasets;Leadership;Link;Lung Transplantation;Metadata;Methodology;Modality;multidimensional data;multiple data types;multiple omics;Names;Nature;Phenotype;Play;Procedures;Process;Production;programs;public repository;Publications;Reagent;Recording of previous events;Reproducibility;Research;Research Design;Research Personnel;Residencies;Resources;response;Role;Running;Serology;Services;single cell sequencing;single-cell RNA sequencing;software development;Specificity;Standardization;Statistical Data Interpretation;Surface;symposium;synergism;System;T cell receptor repertoire sequencing;T cell response;T-Cell Receptor;T-Lymphocyte;Talents;Testing;Tissues;transcriptomics;Validation;Virus Diseases;Visualization;Work

PROJECT_TITLE: Core D: Data and Informatics Service Core


NIH_SPENDING_CATS: Coronaviruses

PROJECT_TERMS: Agreement;Award;B-Lymphocytes;Budgets;Charge;Collaborations;Contracts;design;Development;Direct Costs;Disease;Ensure;Ethics;Evolution;Facilities and Administrative Costs;Financial Support;Funding;Funding Opportunities;Future;Goals;Grant;Human;Immune;Immune system;Immunology;Infrastructure;Institution;Language;Laws;Mediating;member;Mission;Notification;payment;Policies;Prevention;Process;programs;Reagent;Regulation;Reporting;Request for Applications;Research;Research Personnel;Resources;response;Sampling;Scientist;Structure;T-Lymphocyte;United States National Institutes of Health;web site;Work

PROJECT_TITLE: Infrastructure and Opportunity Fund Management Core (IOFMC)


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Coronaviruses;Immunotherapy;Kidney Disease;Organ Transplantation;Transplantation

PROJECT_TERMS: Acute;adaptive immune response;Address;Affect;Affinity;Alleles;Allografting;Amino Acids;Antibodies;Antibody Response;antibody-mediated rejection;Antigens;arm;Autoimmune Diseases;B-Lymphocyte Subsets;B-Lymphocytes;Binding;Biopsy;Blood;Blood specimen;Bone Marrow;Cell Compartmentation;Cell Lineage;Cell secretion;Cells;Chronic;Clinical;Clonal Expansion;Cloning;cohort;Data;design;Development;Diagnosis;donor-specific antibody;Evolution;Excision;Exhibits;experimental study;Future;Goals;Graft Rejection;Histocompatibility Antigens Class I;HLA Antigens;Homeostasis;Human;Immune;Immune response;Immunoglobulin Class Switching;Immunoglobulin-Secreting Cells;Immunologics;Immunomodulators;Immunotherapy;improved;In Situ;Incidence;Infection;Injury to Kidney;Intervention;isoimmunity;Kidney;kidney allograft;Kidney Transplantation;Knowledge;Learning;Life;Link;Lymphoid;Major Histocompatibility Complex;Measures;Mediating;Memory B-Lymphocyte;Monoclonal Antibodies;MS4A1 gene;Mutate;Nephrectomy;Organ failure;organ transplant recipient;organ transplant rejection;Organ Transplantation;pathogen;pathogen exposure;Pathogenesis;Pathogenicity;Patients;Play;Population;precursor cell;prevent;prognostic tool;Property;Proteins;Recombinants;reconstitution;Reporting;Research;Resistance;response;rituximab;Role;Serum;Source;Structure of germinal center of lymph node;success;T-Lymphocyte;Testing;therapy design;Time;Tissue Transplantation;Tissues;Transplant Recipients;Transplantation;Uterus;Vaccination;Work

PROJECT_TITLE: Project 1: Evolution and Durability of allo(auto)immune B cell responses in organ transplant recipients


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Coronaviruses;Genetics;Human Genome;Immunization;Transplantation;Vaccine Related;Women's Health Research

PI_NAMEs: PORRETT, PAIGE M (contact)

PROJECT_TERMS: Address;Affect;Anatomy;antigen test;Antigens;Automobile Driving;B-Lymphocytes;Biological;Biology;Biopsy;Blood;Cell Compartmentation;Cell Differentiation process;Cell Separation;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Circulation;Clone Cells;Data;Data Set;Decidua;Disease;Endometrial;Endometrium;Environment;Environmental Exposure;epigenetic profiling;Epithelial Cells;Event;Evolution;exome sequencing;experience;Exposure to;Flow Cytometry;Gene Expression Profiling;Genes;Genetic Transcription;Health;Human;Human body;human disease;human tissue;Immune;Immune system;Immunity;improved;In Vitro;Individual;Infection;inhibitor;insight;Interleukin-15;Knowledge;Longevity;Longitudinal Studies;Malignant Neoplasms;Measures;Menstrual cycle;Methodology;Mixed Lymphocyte Culture Test;Modeling;Molecular;Morphology;Mus;Natural regeneration;next generation sequencing;nuclear factors of activated T-cells;Organ;Organ Transplantation;Ovulation;pathogen;Pathway interactions;patient population;peripheral blood;Peripheral Blood Mononuclear Cell;pharmacologic;Phase;Physiological;Play;Population;post pregnancy;Progesterone;programs;Proteins;recruit;regenerative;Regulon;residence;Residencies;response;Reverse Transcriptase Polymerase Chain Reaction;Role;Sampling;secondary lymphoid organ;Shapes;Signal Transduction;single-cell RNA sequencing;Stromal Cells;synergism;T cell receptor repertoire sequencing;T memory cell;T-Cell Proliferation;T-Lymphocyte;Testing;Therapeutic;Time;tissue resident memory T cell;Tissues;trafficking;Transforming Growth Factor beta;Transplant Recipients;Transplantation;Uterus;vaccine strategy;volunteer;Women's Health;wound

PROJECT_TITLE: Project 2: Genesis and dynamics of human endometrial resident memory T cells revealed by uterus transplant recipients


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Coronaviruses;Genetics;Infectious Diseases;Lung;Organ Transplantation;Transplantation

PI_NAMEs: RANDALL, TROY D (contact)

PROJECT_TERMS: 2019-nCoV;Affinity;Alleles;Alloantigen;Allografting;Antibodies;Antibody Response;antibody-mediated rejection;Antigens;Appearance;Autoantibodies;Autoantigens;Autoimmune;autoreactive B cell;autoreactivity;B-cell receptor repertoire sequencing;B-Lymphocytes;Bar Codes;Binding;Blood;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chronic Obstructive Pulmonary Disease;Clone Cells;cross reactivity;Data;Development;DNA;donor-specific antibody;Epitopes;Evolution;experimental study;first responder;Functional disorder;Genetic Transcription;high dimensionality;Human;Immunity;Immunoglobulin A;Immunoglobulin G;Individual;Infection;Inflammation;Influenza;influenzavirus;insight;Lavage;Liquid substance;Location;Longevity;Lung;lung allograft;Lung Diseases;Lung infections;Lung Lavage Fluid;lung pathogen;Lung Transplantation;Memory B-Lymphocyte;Methods;migration;Monitor;Mus;pathogen;Pathology;Patients;Population;Process;programs;Reaction;Recombinant Antibody;Residencies;Respiratory Tract Infections;respiratory virus;response;Role;secondary infection;secondary lymphoid organ;self-renewal;Serum;Signal Transduction;single-cell RNA sequencing;Site;Specificity;Structure of parenchyma of lung;Surface;T-Lymphocyte;Testing;Time;tissue resident memory T cell;Tissues;transcriptome;transcriptome sequencing;Transplant Recipients;Transplantation;Vaccination;Variant;Virus

PROJECT_TITLE: Project 3: Evolution, dynamics and durability of B cell and antibody responses in lung transplantation


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE While prior research has documented that transgender and/or nonbinary (TNB) college students experience significant disparities in mental health outcomes, little attention has been paid to the ways in which campus policy environments have shaped these disparities, despite substantial campus-level variation in policies that may uniquely affect TNB students (e.g. counseling staff training and insurance coverage for gender affirming healthcare). Additionally, TNB students across intersections of racial/ethnic identities and socioeconomic status may be differentially impacted by these policy environments due to unique structural vulnerabilities, although no studies have explored this. The objectives of this project are thus to use unprecedented, national data from over 300 institutions to fill this gap and discern the role of campus policy environment in TNB mental health disparities across intersecting social positions, with the goal of informing campus-level interventions for an increasing and diverse population of TNB college students.

PI_NAMEs: PAGLISOTTI, EVEN  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Address;Administrator;Adult;Affect;Area;Attention;Birth;Black race;career;Caring;Categories;Characteristics;cisgender;Classification;Climate;college;Color;Communities;Community Services;Counseling;Data;Data Set;Databases;Disparity;Environment;Epidemiologic Methods;Equity;ethnic identity;Ethnic Origin;experience;Exposure to;Future;Gender;gender affirming care;Gender Identity;Goals;Grant;Health;health disparity;health equity;Health equity research;Health Surveys;high risk;improved;improved outcome;Individual;innovation;Institution;Insurance Coverage;interest;intersectionality;Intervention;Light;Literature;low socioeconomic status;marginalization;Medical;Mental Depression;Mental Health;Mental Health Services;Methods;Mind;minority stress;Modeling;multilevel analysis;multiple data sources;National Institute of Mental Health;nonbinary;novel;Outcome;Pattern;peer;Personal Satisfaction;Policies;Politics;Population Heterogeneity;Professional counselor;Race;racial population;Research;Research Design;Research Personnel;Research Support;Resources;Risk;Role;Sampling;Scientist;sex assigned;Sexual and Gender Minorities;Shapes;social epidemiology;Social status;Socioeconomic Status;Sports;Strategic Planning;structural determinants;Students;Subgroup;suicidal;Testing;theories;Training;transgender;Underserved Population;United States National Institutes of Health;university student;Variant;Woman;Work;young adult;Youth

PROJECT_TITLE: An intersectional approach to transgender and/or nonbinary college student mental health: The role of gender identity, race/ethnicity, socioeconomic status, and campus policy


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Injury;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: The majority of the world's children live in low- and middle-income countries and experience substantial childhood adversity that potentially have lasting negative implications for health, health behaviors and wellbeing of young adults and their children. Yet there are few longitudinal studies from low-income contexts that capture how childhood adversity influences sexual, reproductive and mental health in early adulthood, nor how it is transmitted across generations to their children. By expanding an existing cohort study in Malawi, a low-income country, we will illuminate causal pathways from adversity to health, identify mechanisms, and highlight protective factors – the foundational evidence needed for effective programming.

PI_NAMEs: KIDMAN, RACHEL  (contact);KOHLER, HANS-PETER

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Adolescence;Adult;adverse childhood events;adverse outcome;Affect;Africa South of the Sahara;Age disparity;aged;Automobile Driving;Behavior;Caregivers;Child;Child Development;Child Health;Child Rearing;Childhood;childhood adversity;cohort;Cohort Studies;Communities;Country;critical period;Data;Data Collection;Data Set;Development;Domestic Violence;early adolescence;early childhood;early pregnancy;emerging adult;emerging adulthood;Emotional;experience;Exposure to;Family;Family Study;Fathers;Fertility;Foundations;Future;Generations;Grant;Health;Health behavior;HIV;Human Development;Incidence;Income;Individual;insight;instrument;intergenerational;Intervention;Investments;Language;lens;Life;Life Cycle Stages;Longitudinal Studies;low and middle-income countries;Low income;low income country;Malawi;Marriage;Measurement;Measures;Mediating;Mental Depression;Mental Health;Modeling;Mothers;neglect;offspring;Outcome;Parents;partner violence;Pathway interactions;Personal Satisfaction;Persons;Phase;physical abuse;Policies;Poverty;Process;promote resilience;prospective;protective factors;public health intervention;Quasi-experiment;Reporting;Reproductive Health;Research;resilience;Resources;Sexual abuse;Sexual Health;sexual risk behavior;social;Social support;Source;transition to adulthood;transmission process;Vulnerable Populations;young adult

PROJECT_TITLE: Adversities, Health and Resilience in Early Adulthood: An intergenerational, low-income country study

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


ORG_CITY: HOUSTON

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative Peroxisomes are metabolically plastic organelles housing critical reactions, and peroxisome dysfunction can lead to severe developmental defects in multicellular eukaryotes, including mammals and plants. Peroxisomes contain abundant intralumenal vesicles that have been implicated in lipid metabolism, enzyme compartmentalization, and protein import. The goals of this project are to elucidate how a peroxisomal membrane-shaping protein, PEX11, influences peroxisome membrane architecture to impact global peroxisome function.

PI_NAMEs: THARP, NATHAN  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TITLE: Investigating PEX11 roles in shaping peroxisome architecture and dynamics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Infectious Diseases;Malaria;Neurosciences;Rare Diseases;Vector-Borne Diseases

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Narrative Cerebral malaria is a serious complication of Plasmodium falciparum infection that can lead to death. We are studying the mechanisms underlying the disruption of the blood-brain barrier during cerebral malaria with the aim of identifying potential therapeutic targets.

PI_NAMEs: RODRIGUEZ, ANA  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Affect;Anti-malarials;Astrocytes;Binding;Blood - brain barrier anatomy;blood-brain barrier disruption;Brain;Brain Death;brain endothelial cell;brain tissue;Candidate Disease Gene;candidate identification;Cause of Death;cell type;Cerebral endothelium;Cerebral Malaria;Cessation of life;Cholesterol;Complication;Crystallization;Development;Digestion;Edema;Endothelial Cells;Endothelium;Environment;enzyme deficiency;Enzyme Inhibition;enzyme substrate;Enzymes;Erythrocytes;Family;Farnesyl Transferase Inhibitor;farnesylation;Genes;Hemoglobin;Hemorrhage;hemozoin;Human;In Vitro;in vitro Model;Incubated;Individual;Infection;Intercellular Junctions;Intervention;Knowledge;Malaria;Mediating;Microcirculation;Microglia;Modeling;Molecular;mortality;Mus;Neurologic Signs;Neurons;neurovascular unit;Obstruction;Parasites;Pathway interactions;Patients;Pericytes;physiologic model;Plasmodium falciparum;prevent;Process;Protein Farnesylation;protein farnesyltransferase;Proteins;Regulation;response;rho GTP-Binding Proteins;Role;Signal Induction;Signal Transduction;Syndrome;targeted treatment;Testing;therapeutic target;Tipifarnib;transcriptome sequencing;transcriptomics;Validation;Work

PROJECT_TITLE: Brain endothelial barrier disruption during cerebral malaria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-M (02)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects

ORG_CITY: Chicago

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Trips account for over 50% of falls each year, leading to an enormous physical, psychosocial, and financial burden on the population. Older adults with mild cognitive impairment experience twice as many falls as cognitively intact older adults; however, it has rarely been examined how mild cognitive impairment affects the ability to prevent falling and recover balance when unexpected perturbations are experienced. In this study, we will examine differences in reactive balance between older adults with and without mild cognitive impairment when exposed to trip perturbations while walking on a treadmill to investigate the mechanisms underlying increased fall risk in this population.

PI_NAMEs: PITTS, JESSICA  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Affect;aging population;balance recovery;Biomechanics;Cessation of life;Clinical;Cognitive;Dementia;design;Detection;Electroencephalography;equilibration disorder;Equilibrium;Evoked Potentials;experience;Exposure to;Fall prevention;fall risk;falls;feasibility testing;Feedback;Financial Hardship;Frequencies;Future;Gait;gray matter;Hospitalization;Impairment;improved;Incidence;Investigation;Laboratories;Life;Limb structure;Medical Care Costs;mild cognitive impairment;Modeling;Motor;Muscle;neural;neuroimaging;neuromuscular;novel;older adult;Outcome;Pathology;Population;Predisposition;Protocols documentation;psychosocial;response;Role;Structure;Surface;synergism;Techniques;theories;Training;treadmill;Update;Walking;white matter

PROJECT_TITLE: The effect of mild cognitive impairment on reactive stepping responses and motor adaptation to trip perturbations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-C (20)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PHR: Project Narrative Neurotransmission and proper circuit function are crucial for processing environmental stimuli. Critical to these processes are calcium fluctuations within single neurons, however intracellular contributions to these fluctuations have remained largely unexplored. This proposal aims to uncover the contribution of endoplasmic reticulum calcium handling to neurotransmission in a well-characterized Drosophila neural circuit, informing our understanding of neurotransmission and circuit function at the level of the human brain.

PI_NAMEs: DELGADO, KATHERINE COFFIN (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Affect;Axon;Behavioral;Brain;Calcium;Calcium Channel;calcium indicator;Calcium Signaling;career;cell type;Cells;Cellular biology;Data;Dendrites;Detection;Drosophila genus;Drosophila melanogaster;Dynamin;Endoplasmic Reticulum;Exocytosis;experimental study;Eye diseases;Fellowship;fly;Genetic;genetic manipulation;Human;Image;In Vitro;in vivo;in vivo imaging;insight;Interneurons;Invertebrates;Link;Logic;Measures;Membrane;Membrane Potentials;Methods;model organism;Molecular;Motion;Nerve Degeneration;neural circuit;neuroimaging;Neurons;neurotransmission;Neurotransmitter Receptor;neurotransmitter release;novel;Organism;postsynaptic;presynaptic;Presynaptic Terminals;Process;Property;Reproducibility;Research;response;Retinal Degeneration;Role;Shapes;signal processing;Signal Transduction;skills;Stimulus;Synaptic Vesicles;System;Testing;tool;Training;training opportunity;two photon microscopy;two-photon;uptake;Vision;Visual;visual stimulus;Visual System;Vocational Guidance;voltage;Work

PROJECT_TITLE: Linking endoplasmic reticulum calcium handling to neuronal function in vivo in the Drosophila visual system

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: The proposed research will provide insights into the molecular responses of kidney cells to saturated lipid induced injury, specifically, the mechanism by which deletion of Fas-associated factor 2 (FAF2) is protective against lipid induced cellular toxicity, known as lipotoxicity. Lipotoxicity can lead to cell injury and death and has been implicated in the pathogenesis of chronic kidney disease. Elucidating the molecular mechanisms of lipotoxicity in the kidney may contribute to the development of therapeutic strategies for diseases lacking treatment options.

PI_NAMEs: GABRIEL, KATLYN ROSE (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Apoptosis;Apoptotic;Aptitude;Automobile Driving;Biology;career;Cause of Death;Cell Death;Cell Death Induction;cell injury;Cell membrane;Cell Survival;Cells;Cellular biology;Cellular Stress;Cessation of life;Chronic;Chronic Kidney Failure;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;Cytoprotection;desaturase;Development;Dialysis procedure;Diet;Disease;Disease Progression;Doctor of Philosophy;End stage renal failure;endoplasmic reticulum stress;Environment;Epidemiology;Epithelial Cells;Exposure to;Fatty Acids;Fellowship;Fibrosis;Functional disorder;Future;genome wide screen;genome-wide;Goals;Growth;High Fat Diet;high risk;high throughput screening;Human;Hyperlipidemia;In Vitro;in vivo;Injury;Injury to Kidney;insight;Investigation;Kidney;kidney cell;kidney dysfunction;kidney epithelial cell;Kidney Transplantation;Knock-out;Knockout Mice;Knowledge;laboratory experience;Lead;lipid metabolism;Lipids;Mediator;Membrane;Molecular;Molecular Biology;mouse model;Mus;new therapeutic target;Nonesterified Fatty Acids;novel;novel therapeutic intervention;Organ failure;Palmitates;Palmitic Acids;Pathogenesis;Pathway interactions;Phospholipids;Physiological;Process;Proteins;Proximal Kidney Tubules;Public Health;Regulation;renal damage;Renal function;Research;response;Risk Factors;Role;saturated fat;Saturated Fatty Acids;Scientist;skills;stearoyl-coenzyme A;Stress;Technology;Testing;Therapeutic;therapeutic development;tissue injury;Tissues;Toxic effect;Training;treatment strategy;Tubular formation;Validation;Work

PROJECT_TITLE: Mechanisms of Renal Lipotoxicity

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-G (O1)]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: NARRATIVE Nuclear receptors evolved to respond to small molecules, translating these signals into changes in gene expression. Our data, that RORα transcriptionally regulates TH17 cell pathogenicity and ligand regulation affects chronic inflammation, suggests that RORα may be a key transcriptional regulator of this cell type. The proposed studies will address fundamental questions regarding the transcriptional role of RORα, insights which will be particularly valuable understanding TH17-mediated chronic inflammation and whether targeting this nuclear receptor may be therapeutically relevant.

PI_NAMEs: SOLT, LAURA A (contact)

PROGRAM_OFFICER_NAME: NGUYEN, KHOA DINH DANG

PROJECT_TERMS: Affect;Anti-Tumor Necrosis Factor Therapy;Autoimmune;Automobile Driving;Biological Process;cell type;Cells;Cellular biology;Chromatin;Chronic;Circadian Rhythms;Clinical;cofactor;Colitis;Crohn's disease;cytokine;Cytoprotection;Data;Development;Disease;effective therapy;experimental study;extracellular;Family member;Gene Expression;Genes;Genetic;Genetic Transcription;glucose metabolism;Goals;Homeostasis;Immune response;Immune system;Immunity;In Vitro;in vivo;in vivo Model;Infiltration;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Ligands;lipid metabolism;Mediating;member;Metabolic;Metabolic Pathway;Molecular Biology;mouse model;Mucous Membrane;Mus;NCOA2 gene;novel therapeutics;Nuclear Receptors;pathogen;Pathogenesis;Pathogenicity;Patients;pharmacologic;Physiological Processes;predictive marker;prevent;Process;programs;Publishing;receptor;receptor function;recruit;Refractory;Regulation;Research;response;response biomarker;Role;RORA gene;Signal Pathway;Signal Transduction;small molecule;Subgroup;T-Lymphocyte;Therapeutic;Tissues;Transcription Coactivator;transcription factor;Transcriptional Regulation;Translating;Ulcerative Colitis;Work

PROJECT_TITLE: Ligand and transcriptional regulation of the nuclear receptor RORa on TH17 cell development and inflammation

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Alzheimer’s disease affects over 50 million people globally and is estimated to cost the healthcare system upwards of 1 trillion dollars annually. Recent studies suggest that Alzheimer’s disease is influenced by the immune system. My studies will examine the role that a subset of immune cells, called regulatory T cells, play in preventing or delaying the onset of Alzheimer’s disease.

PI_NAMEs: HOUGARD, THOMAS R (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Activities of Daily Living;Adult;Affect;Age;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Astrocytes;Beds;behavior measurement;Biochemical;Brain;Cell Communication;Cell Count;Cell Physiology;Cells;Cessation of life;Chronic;Clinical;cost;Data;decubitus ulcer;Dementia;design;Deterioration;Diagnosis;Disease;Disease Progression;early onset;Effector Cell;Exhibits;experimental study;extracellular;Flow Cytometry;FOXP3 gene;Functional disorder;Functional impairment;Grant;Health;Health Care Costs;Healthcare Systems;Histologic;Human;human old age (65+);hyperphosphorylated tau;IL2RA gene;Immune;Immune response;Immune system;Impaired cognition;improved outcome;Infection;Inflammatory;Injections;Injury;insight;Intervention;Knowledge;Language;Learning Difficulty;Location;long term memory;Lymphocyte;magnetic beads;Maps;Measures;Memory;Microglia;misfolded protein;Modeling;Mus;Muscular Atrophy;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;neuron loss;Neurons;neurotoxic;old mice;Patients;Persons;Phenotype;Play;Pneumonia;Population;pre-clinical;prevent;Proteomics;Regulatory T-Lymphocyte;Role;Senile Plaques;Severities;Signs and Symptoms;single-cell RNA sequencing;Symptoms;System;systemic inflammatory response;T-Cell Depletion;T-cell diversity;T-Lymphocyte;T-Lymphocyte Subsets;Tamoxifen;tau Proteins;Testing;Time;tissue repair;Tissues;tool;Training;transcription factor;United States;Wild Type Mouse

PROJECT_TITLE: The Role of Regulatory T Cells in Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-N (20)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Substance Misuse

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative Jails are critical healthcare access points for people with opioid use disorder (OUD) who are incarcerated, yet access to medications for opioid use disorder (MOUD) in jails remains limited. This mixed-methods study will examine the implementation of MOUD in Massachusetts jails through qualitative interviews with jail staff and people who received MOUD while incarcerated, survey analysis of jail staff to examine the impacts of organizational factors on staff perceptions of MOUD, and modeling of the effects of MOUD treatment during incarceration on post-release engagement with MOUD treatment using the Massachusetts Public Health Data (PHD) Warehouse database. This study will elucidate strategies to improve implementation of MOUD in jail settings and will seek to improve accessibility of evidence-based OUD treatment for people who are incarcerated.

PI_NAMEs: MICHENER, PRYCE  (contact)

PROGRAM_OFFICER_NAME: MULFORD, CARRIE FRIED

PROJECT_TERMS: addiction;Address;American;Buprenorphine;Cause of Death;Clinical;clinical training;Collaborations;Communities;comorbidity;County;Data;Data Scientist;data warehouse;Databases;Diffusion;Drug Tolerance;Education;effective therapy;Effectiveness;effectiveness/implementation study;evidence base;Evidence based treatment;experience;Exploration, Preparation, Implementation, and Sustainment;FDA approved;Funding;Future;Goals;Health;health care availability;Health Services;Health Services Research;Healthcare;high risk population;Illicit Drugs;implementation science;Imprisonment;improved;Individual;innovation;insight;Interview;Jail;Justice;Knowledge;Legal;Massachusetts;medical schools;medication for opioid use disorder;Medicine;Mentors;Methadone;Methods;Modeling;mortality;Movement;multidisciplinary;Naltrexone;National Institute of Drug Abuse;Opioid;opioid epidemic;opioid mortality;opioid overdose;opioid use disorder;Outcome;Overdose;overdose death;Overdose reduction;overdose risk;Perception;Persons;Pharmaceutical Preparations;Physicians;Policies;Population;prevent;Principal Investigator;Prisons;programs;Public Health;Readiness;Research;Research Personnel;Risk;Risk Reduction;Scientist;Staff Attitudes;Strategic Planning;Surveys;Time;tool;Training;treatment strategy;United States;Vulnerable Populations;Work

PROJECT_TITLE: Implementation of Medications for Opioid Use Disorder in Massachusetts Jails

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: ALBANY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: PROJECT NARRATIVE Investigating host-driven substitutions and potential adaption to novel transmission cycles is essential in understanding the current spread and reemergence of the tickborne flavivirus, Powassan virus (POWV). Recent isolations of POWV from novel tick species in New York State augment concerns over viral spillover and spread into new transmission cycles. Investigating the adaptive potential of emergent POWV isolates in distinct tick hosts and emergent host-specific substitutions is vital in understanding POWV ecology and predicting potential viral diversification.

PI_NAMEs: LANGE, RACHEL  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Amblyomma;Ambylomma americanum;Anti-viral Response;Automobile Driving;Black-legged Tick;Data;Dermacentor;Ecology;Evolution;Family;fitness;Flaviviridae;Flavivirus;Frequencies;Genetic;Genetic Determinism;genetic signature;Genetic Variation;Genotype;Geography;Goals;Human;Immune Evasion;Immune response;Infection;Measures;Minority;Modeling;Molecular;mosquito-borne;Mutation;New England;New York;North America;novel;novel virus;Nymph;Output;Phenotype;Population;Population Heterogeneity;Powassan virus;pressure;Proteins;RNA Interference;Role;Russia;Site;Specificity;Squirrel;Testing;tick-borne flavivirus;tick-borne virus;Ticks;Time;tool;transmission process;vector;Viral;viral fitness;Viral Proteins;Virus;Virus Diseases;Virus Replication;Woodchuck;Work

PROJECT_TITLE: Investigating the Genetic Determinants of Host-Specificity and Potential for Further Adaptation of Powassan Virus