NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Contraception/Reproduction;Estrogen;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Women's Health Research

ORG_CITY: IRVINE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE  This competitive renewal RO1 application aims to further dissect the mechanisms by which hydrogen sulfide, a novel uterine artery dilator we pioneered the last funding cycle, utilizes to mediate estrogen- induced uterine vasodilatation in normal pregnancy and how these mechanisms are impaired in preeclampsia. New data obtained will enhance the cellular and molecular understanding of estrogens, ion channels, uterine artery vascular smooth muscle contractility and tone, and uterine blood flow. The knowledge will in turn inform new pathways to assist the development of therapeutics for combating preeclampsia and other pregnancy failures and will also shed lights on the understanding of the cardiovascular protective effects of estrogens.

PI_NAMEs: CHEN, DONGBAO  (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Arteries;Bathing;Biochemical;Biological Process;Biology;Blood flow;Blood Vessels;Cardiovascular system;Cell Separation;Closure by clamp;Complex;Cystathionine;Cystathionine beta-Synthase;Cysteine;Cysteine Desulfhydrase;Data;Development;Dilator;druggable target;Electrophysiology (science);Endothelial Cells;Endothelium;Enzymes;ESR1 gene;Estrogen Receptor 2;Estrogen Receptors;Estrogens;Funding;Genetic;Genetic Transcription;Grant;hemodynamics;Human;Hydrogen Sulfide;Hysterectomy;Impairment;In Vitro;in vivo;Ion Channel;Knock-out;Knowledge;Mediating;Mesentery;Messenger RNA;Modeling;Molecular;Mus;mutant;Myometrial;Nitric Oxide;NOS3 gene;novel;Organ;Oxidation-Reduction;Oxides;Pathway interactions;persulfides;pharmacologic;Physiological;Pilot Projects;Play;Potassium;Potassium Channel;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy disorder;pregnancy failure;pregnant;pressure;Primary Cell Cultures;Production;protective effect;Proteins;Proteomics;Rattus;Regulation;Relaxation;Reporting;Research;Role;Route;Sampling;Shapes;Signal Transduction;Site;Smooth Muscle;Smooth Muscle Myocytes;sulfhydration;Sulfhydryl Compounds;System;Testing;Therapeutic;therapeutic development;Up-Regulation;Uterus;Vascular Smooth Muscle;Vasodilation;Vasodilator Agents;voltage;Voltage-Gated Potassium Channel;Woman;Work

PROJECT_TITLE: Actions of Estrogen on Uterine Artery Endothelium

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: GREATER LOS ANGELES VETERANS RESEARCH AND EDUCATION FOUNDATION

ORG_STATE: CA

PI_NAMEs: KRALL, BONITA  (contact)

PROJECT_TERMS: Advocacy;Autopsy;Brain;brain control;brain tissue;Collection;Communities;Contracts;cost;Disease;Goals;Human;human disease;Mental disorders;National Institute of Child Health and Human Development;National Institute of Drug Abuse;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;National Institute on Aging;Nervous System Disorder;Neurodevelopmental Disorder;Patients;Performance;Process;Research;Resources;Site;Tissue Banks;Tissues;United States National Institutes of Health

PROJECT_TITLE: NIH NEUROBIOBANK BRAIN AND TISSUE REPOSITORYCONTRACT TYPE: COST, OPTIONPERIOD OF PERFORMANCE: 09/01/2019 TO 08/31/2020


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: NAGRA, RASHED  (contact)

PROJECT_TERMS: Alzheimer's Disease;Brain;cost;Performance;Tissues;United States National Institutes of Health

PROJECT_TITLE: NIH NEUROBIOBANK BRAIN AND TISSUE REPOSITORYCONTRACT TYPE: COST, OPTIONPERIOD OF PERFORMANCE: 09/01/2021 TO 08/31/2022ADDITIONAL FUNDING


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Nutrition;Orphan Drug;Rare Diseases

ORG_CITY: GAITHERSBURG

ORG_STATE: MD

PROJECT_TERMS: gene therapy;ketotic hyperglycinemia;Lead;lead candidate;Maintenance;meetings;methylmalonic aciduria;pre-Investigational New Drug meeting;Preparation

PROJECT_TITLE: REGULATORY SUPPORT FOR LEAD GENE THERAPY CANDIDATES AS A TREATMENT FOR ORGANIC ACIDEMIAS, PROPIONIC ACIDEMIA (PA) AND METHYLMALONIC ACIDEMIA TYPE B (MMAB)


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: FORT COLLINS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Synucleinopathies, including multiple system atrophy (MSA), are fatal movement disorders caused by the misfolding and self-templating of the protein α-synuclein. Little is known about how the biochemical features of each misfolded shape, or strain, of α-synuclein contributes to disease presentation. The long-term goal of these studies is to determine how strain-specific differences in axonal transport, titer, and trans-synaptic spread impact disease pathogenesis.

PI_NAMEs: WOERMAN, AMANDA L. (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Affect;alpha synuclein;American;Anatomy;Area;Axonal Transport;Binding;Biochemical;Biological;Biological Assay;Biology;biophysical properties;Brain;Cell Line;Cell model;Central Nervous System;Chemicals;Chimeric Proteins;Clinical;clinical heterogeneity;conformer;Disease;disease heterogeneity;disease phenotype;Disease Progression;Dynein ATPase;Exhibits;experimental study;Genetic;Goals;Heterogeneity;Human;In Vitro;in vivo;in vivo imaging;Injections;innovation;insight;Integration Host Factors;Investigation;Knowledge;Label;Mammalian Cell;Maps;Microtubule Polymerization;Modeling;Molecular;Molecular Conformation;Motor Activity;mouse model;Movement Disorders;Multiple System Atrophy;Mus;nerve transection;Nervous System Disorder;Neural Pathways;Neuroanatomy;Neurodegenerative Disorders;Neurons;neuropathology;Parkinson Disease;Pathogenesis;Pathway interactions;Patients;Pattern;Peripheral;pre-formed fibril;prion-like;Prions;Property;protein misfolding;Proteins;Recombinants;Research;Role;Route;Sampling;sciatic nerve;Shapes;skills;Source;Structure;Sucrose;Symptoms;Synapses;synucleinopathy;Testing;Therapeutic;Therapeutic Intervention;Tissues;tool;Transgenic Mice;transmission process;transport inhibitor;Work

PROJECT_TITLE: Effect of Agent and Host Factors on Alpha-Synuclein Strain Pathogenesis

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: EUGENE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project Narrative The proposed studies will establish the molecular mechanisms of cobamide selectivity and transport in a common gut bacterium Bacteroidetes thetaiotaomicron, providing the first structural and mechanistic insights into B12 trafficking and selectivity. This study will also contribute to understanding the chaperone activities of BtuR, the enzyme responsible for the synthesis of 5’-deoxyadenosylcobalamin, the active form of the cofactor that is required by some enzymes and for gene regulation via B12-dependent riboswitches.

PI_NAMEs: MASCARENHAS, ROMILA NINA (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Address;Affinity;Anabolism;Bacteria;Bacteroides thetaiotaomicron;Bacteroidetes;beta barrel;Binding;Biochemical;Biochemical Reaction;Biological Assay;biophysical techniques;Carbon;Carrier Proteins;Cells;Cobalamin;cobamamide;cofactor;Communities;Complex;Corrinoids;cost;Disease;dysbiosis;Ecosystem;Environment;Enzymes;Equilibrium;Escherichia coli;fitness;Fluorescence;Gene Expression Regulation;Genes;Gram-Negative Bacteria;gut bacteria;gut microbiome;Health;Homologous Gene;Human;Human Genome;Individual;Individual Differences;insight;interest;Kinetics;Lipoproteins;Measures;Membrane;Membrane Transport Proteins;Metabolic;Metabolic Pathway;Metabolism;Metagenomics;Methylmalonyl-CoA Mutase;microbial;microbial community;microbial composition;microbiome;microbiota;model organism;Molecular;Molecular Chaperones;Nitrogen;Operon;Oxidation-Reduction;paralogous gene;Periplasmic Binding Proteins;Phase;Play;Predisposition;preference;Process;protein protein interaction;protein transport;Proteins;Reaction;Research;Resources;Ribonucleotide Reductase;Role;Shapes;Signal Transduction;Site;Specificity;Structure;Surface;symbiont;System;Testing;Therapeutic;Thermodynamics;trafficking;treatment response;uptake;Vitamin B 12;Vitamins

PROJECT_TITLE: Vitamin B12 trafficking and selectivity in gut bacteria

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Hydrocephalus;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Stroke

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE (Parent Grant) Germinal matrix intraventricular hemorrhage (IVH) occurs in 15-20% of babies born before 32 weeks of pregnancy. Lifelong consequences may include post-hemorrhagic hydrocephalus (PHH), developmental delay, and cerebral palsy. We propose to use cutting-edge optical, genetic, molecular, and clinically informed approaches in our mouse model of neonatal IVH to test if two distinct and complementary endogenous responses to intraventricular blood can be harnessed to mitigate IVH sequelae: (1) ChP-NKCC1 gene therapy to remove excess CSF, and (2) macrophage clearance of ventricular blood. Our findings will give insight into the sequence and causality of events following IVH, unveil new therapeutic targets, and test the first potential gene therapy for PHH.

PI_NAMEs: LEHTINEN, MARIA  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: absorption;Adult;Apical;Blood;blood product;Brain;Brain hemorrhage;brain tissue;Calcium;Cell secretion;Cells;Cerebral Palsy;Cerebral Ventricles;Cerebrospinal Fluid;chloride-cotransporter potassium;Choroid Plexus Epithelium;Clinical;clinical development;Clinical Treatment;Data;Development;Developmental Delay Disorders;Embryo;Epithelial Cells;Equilibrium;Etiology;Event;Excision;experience;extracellular;Extravasation;Fluids and Secretions;FOS gene;gene therapy;Genetic;Goals;Hemorrhage;Home;Homeostasis;Hydrocephalus;Immediate-Early Genes;Immune;improved outcome;Infant;Inflammatory;insight;Intraventricular;intraventricular hemorrhage;Ions;Liquid substance;Macrophage;Membrane Proteins;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;Neonatal;Neurologic Deficit;new therapeutic target;novel;Optics;parent grant;Pathogenicity;Phosphorylation;Physiological;Pregnancy;Premature Infant;Process;Production;Reaction;recruit;response;Severities;Signal Transduction;Site;Structure of choroid plexus;Surface;System;Testing;Therapeutic;Ventricular;Water

PROJECT_TITLE: Targeting the Choroid Plexus-Cerebrospinal Fluid System to Treat Post-Hemorrhagic Hydrocephalus


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative We have identified the Hippo pathway regulator KIBRA as a novel mediator of podocyte injury. The proposed research will define upstream regulators of KIBRA, delineate a non-canonical KIBRA-TEAD signaling axis, and test novel potential therapeutic strategies for podocyte injury.

PI_NAMEs: MELIAMBRO, KRISTIN  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Actins;Adhesions;Agonist;Biochemical;Biomechanics;Biophysics;Biopsy;Brain;candidate identification;Cells;Chronic;clinically relevant;Cytoplasm;Cytoskeleton;Data;Development;diabetic;Diabetic Nephropathy;Disease;disease model;Disease Progression;Down-Regulation;Drug Kinetics;Event;Family;Focal Adhesions;Focal and Segmental Glomerulosclerosis;Funding;Gene Expression;Genes;glomerular basement membrane;Goals;Human;Hyperglycemia;Impairment;In Vitro;in vitro Model;in vivo;Individual;inhibitor;inhibitor therapy;Injury;Investigation;Kidney;kinase inhibitor;Mediating;Mediator;MicroRNAs;Modeling;mouse model;Mus;novel;novel therapeutic intervention;parent grant;Pathway interactions;Patients;pharmacologic;Phosphotransferases;podocyte;Protein Inhibition;Proteins;Regulation;Renal glomerular disease;Repression;Research;Risk;Role;Scaffolding Protein;Signal Pathway;Signal Transduction;Signaling Protein;SOX4 gene;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Therapeutic Intervention;therapeutic target;transcription factor;Transcriptional Regulation;transcriptome sequencing;Treatment Efficacy;treatment strategy;Up-Regulation;Validation;Work

PROJECT_TITLE: KIBRA-induced biomechanical changes and therapeutic targeting in podocytes


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Human population history is of importance to public health because it determines the genetic variants that individuals and populations inherit, which in turn make some people more or less susceptible to disease. The exponential increase ancient DNA data—from 0 genomes a decade ago to more than 10000 today—creates extraordinary new opportunities, but methods for analysis have not caught up to the data. This grant will support the development of a complete toolkit for using ancient DNA for studying biology and history, and in addition to papers describing these methods and their application, will produce two major resources: publicly available software and a high quality reprocessed version of the world's ancient DNA data.

PI_NAMEs: REICH, DAVID E (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Address;Admixture;African American population;African ancestry;analytical method;Asia;Biology;Communities;Computer software;Data;Development;Disease;disorder risk;DNA;Event;Funding;gene discovery;Genes;Genetic Predisposition to Disease;Genetic Recombination;genetic variant;Genetic Variation;Genome;genome-wide;Genomics;Grant;Graph;Human;Human Biology;human population study;Individual;Inherited;insight;Laboratories;Learning;Link;Malignant neoplasm of prostate;Medical Genetics;method development;Methods;Modeling;Modernization;Paper;Persons;Population;Predisposition;Process;programs;Public Health;Publications;Recording of previous events;Research;Resolution;Resources;Risk Factors;Shapes;study population;synergism;tool;user-friendly;Variant;Work

PROJECT_TITLE: Solving ascertainment bias in ancient DNA using Ultima Genomics sequencing


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Urologic Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: ARBOR RESEARCH COLLABORATIVE FOR  HEALTH

ORG_STATE: MI

PHR: Contact PD/PI: Merion, Robert M Project Narrative The Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) II will study people who have symptoms of lower urinary tract dysfunction (LUTD). The scientific collaborators will use data collected during the studies to refine symptom-based patient clusters that will help doctors better diagnose and treat the symptoms of LUTD and try to determine whether there are biomarkers that can help improve our understanding of these symptoms and the diseases that cause them. The scientists will ask patients to participate in studies that will include the development of surveys to help assess treatment outcomes in future trials of new treatments for LUTD. Page 7 Project Narrative

PI_NAMEs: GRAFF, JOHN JOSEPH (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Biological Markers;Charge;Clinical;Clinical Management;clinical phenotype;Clinical Research;clinical research site;Clinical Treatment;Communication;Data;Data Analyses;Data Coordinating Center;data management;design;Development;Diagnosis;Diagnostic;Disease;expectation;Functional disorder;Funding;Future;Goals;improved;insight;instrument;Lower urinary tract;lower urinary tract symptoms;Measurement;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Organ;Participant;Patient Care;Patient Self-Report;patient subsets;Patient-Focused Outcomes;Patients;Performance;Persons;Pilot Projects;Population;quality assurance;Research;Research Design;Research Personnel;response;Scientist;Self Assessment;Severities;Site;Surveys;symptom treatment;Symptoms;tertiary care;tool;Treatment outcome;treatment response;treatment trial;urinary

PROJECT_TITLE: Continuation of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Data Coordinating Center


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Human Genome;Physical Activity;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MADISON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE In the elderly, tissue regeneration is impaired and repeated injury often precludes the health benefits of exercise. My proposal will determine if the loss of lysine methyltransferase 5a (Kmt5a) and subsequently Kmt5a-mediated methylation of lysine 20 on histone H4 (H4K20me1) during aging disrupts muscle stem cell quiescence, consequently impairing skeletal muscle regeneration. Data generated by this proposal will first (K99) define Kmt5a role in quiescent muscle stem cells at homeostasis and in response to a skeletal muscle injury during aging, and then (R00) define H4K20me1 as an epigenetic modification that can be stimulated by exercise to rejuvenate muscle and hematopoietic stem cell function in the context of aging.

PI_NAMEs: BLANC, ROMEO SEBASTIEN (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Acute;Adult;adult stem cell;Affect;Age;Age Months;age related;Age related comorbidities;aged;Aging;ATAC-seq;career;Cell Count;Cell Culture System;cell regeneration;Cells;Chromatin;Chronic;cytokine;Data;Data Collection;Development;Disease;DNA Polymerase II;Elderly;Environment;Enzymes;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Event;Exercise;Extramural Activities;Flow Cytometry;Functional disorder;Funding;Future;Gene Expression;Gene Silencing;Genes;Genetic Models;Genetic Transcription;genome-wide;genome-wide analysis;Genomics;Goals;Health Benefit;healthy aging;Hematopoietic stem cells;Histone H4;Homeostasis;Human;Image;Impairment;improved;Individual;inducible Cre;Inflammation;Inflammatory;Injury;insight;Knockout Mice;large datasets;Ligands;Lysine;Maintenance;Mammals;Measures;Mediating;Mentors;Mentorship;Methylation;Methyltransferase;Modeling;Moderate Exercise;Modification;Molecular;mouse genetics;Mus;Muscle;muscle aging;muscle progenitor cell;muscle regeneration;Natural regeneration;notch protein;novel;old mice;Phase;Phenotype;Phosphorylation;Physiological;Plasma;Positioning Attribute;preservation;prevent;Process;Productivity;programs;promoter;Quality of life;Reaction;Recovery;regeneration function;Regenerative capacity;Regulation;Regulator Genes;Regulatory Element;Rejuvenation;Reporting;Repression;Research;response;restoration;RNA;RNA Polymerase II;Role;Running;sedentary;self-renewal;Serine;Signal Transduction;Skeletal Muscle;Skeletal muscle injury;skills;small molecule inhibitor;Sorting;stem cell aging;stem cell biology;stem cell fate;stem cell function;stem cell population;stem cell therapy;stem cells;Stimulus;Tamoxifen;Techniques;Testing;TFF1 gene;tissue regeneration;Tissues;Training;Transcription Initiation Site;Transcriptional Regulation;transcriptome sequencing;translational medicine;Work

PROJECT_TITLE: Targeting H4K20 methylation to rejuvenate aged stem cell epigenome and regenerative function.


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Programmed DNA damage regulates core biological processes, but may also create challenges for genome integrity, especially in long-lived neurons. Both deficiency and overactivity of programmed DNA damage at neuronal enhancers may contribute to neurodegeneration, including in age-related frontotemporal dementia and Alzheimer’s disease. This proposal uses iPSC-derived human neurons and in vivo CRISPR interference mouse models to uncover how programmed DNA damage is regulated and the consequences of dysregulation for epigenetic remodeling and mutational frequency.

PI_NAMEs: KARGBO-HILL, SARAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: age related;age related neurodegeneration;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Antisense Oligonucleotides;Architecture;Biological Process;Brain;career;Cell Physiology;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR interference;CRISPR-mediated transcriptional activation;Data;Defect;demethylation;design;Development;Disease;DNA;DNA Damage;DNA Methylation;DNA Repair;DNA Repair Gene;DNA Repair Inhibition;Enhancers;Epigenetic Process;Event;exon skipping;experimental study;Frequencies;Frontotemporal Dementia;Functional disorder;Gene Expression;Genetic Transcription;genome integrity;Genomics;Goals;Image;Immersion;Impaired cognition;Impairment;in vivo;Induced Mutation;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;insight;knock-down;Learning;Libraries;life span;limbic-predominant age-related TDP-43 encephalopathy;link protein;live cell imaging;Mentors;Methods;Monitor;mouse model;Mus;Mutate;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;neuronal survival;Neurons;new therapeutic target;novel;old mice;Organism;particle;Pathogenesis;Pathogenicity;Pathologic;Phase;Play;prevent;Process;promoter;protein TDP-43;Proteins;repaired;Research;response;Risk;RNA;RNA Splicing;Role;Shapes;Site;Somatic Mutation;Stimulus;Synapses;Techniques;Testing;Therapeutically Targetable;Training;transcription factor TFIIH;Transcription Initiation;Transcriptional Activation;Transcriptional Regulation;United States National Institutes of Health;ward;XRCC1 gene

PROJECT_TITLE: Programmed DNA Damage and its Role in Alzheimer's Disease and Related Dementias


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Infertility

ORG_CITY: STONY BROOK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PD/PI: Takemaru, Ken-Ichi 8. PROJECT NARRATIVE Infertility is a public health issue, affecting approximately 15% of all couples, and in about 50% of cases, a male factor is involved. The sperm flagellum is responsible for sperm motility and fertilization of the egg, but how flagella are properly formed remains poorly understood. Our research focuses on understanding the roles of Chibby (Cby) family members and their binding proteins in the formation and function of sperm flagella, thereby contributing to our better understanding of male germ cell development.

PI_NAMEs: TAKEMARU, KEN-ICHI  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Affect;Apical;Binding;Binding Proteins;Biological Process;Cell surface;Cilia;ciliopathy;cilium biogenesis;cilium motility;Complex;constriction;Couples;Curiosities;Data;Development;Disease;Exhibits;Family member;Fertility;Flagella;Goals;Human;in vivo;Infertility;insight;Liquid substance;Locomotion;male;male fertility;Male Infertility;Membrane;Microtubules;migration;Modeling;Molecular;mouse model;Movement;Mus;novel;Patients;Phenotype;Physiological;Positioning Attribute;Primary Ciliary Dyskinesias;Proteins;Public Health;Research;Role;Shapes;Signal Transduction;sperm cell;sperm function;Sperm Motility;Sperm Tail;Spermatocytes;Spermatogenesis;Structure;Tail;Tertiary Protein Structure;Testis;zygote

PROJECT_TITLE: The Role of Chibby Family Members in Spermatogenesis and Male Fertility


NIH_SPENDING_CATS: Genetics;Neurosciences

PHR: Project Narrative Neurons depend on the transport of mRNA down axons and dendrites so that the mRNA can be translated into proteins locally. We uncovered a mechanism by which mRNA travels on mitochondria by binding to a protein called synaptojanin2. We now ask what species of mRNA use this method of transportation and how important the mechanism is for the health of neurons, synapses, and neuronal mitochondria.

PI_NAMEs: SCHWARZ, THOMAS L. (contact)

PROJECT_TERMS: Axon;Axonal Transport;Binding;Binding Proteins;Catalogs;Dendrites;Health;human induced pluripotent stem cells;Inositol;Lipids;Mediating;Messenger RNA;Methods;Mitochondria;mitochondrial messenger RNA;Mitochondrial Proteins;Morphology;Mus;Mutation;neuronal cell body;neuronal survival;neuronal transport;Neurons;Phosphoric Monoester Hydrolases;PINK1 gene;preservation;presynaptic;prevent;Proteins;RNA Recognition Motif;Synapses;Synaptosomes;SYNJ1 gene;Transcript;Translating;Translations;Transportation;Travel

PROJECT_TITLE: Axonal Transport of mRNA for Mitochondrial Proteins (Diversity Supplement)


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Sexually Transmitted Infections;Social Determinants of Health

PHR: PROJECT NARRATIVE Transgender men who have sex with men (trans MSM) are an underserved NIH health disparities population at-risk of HIV acquisition in the US and require gender-affirming culturally responsive public health strategies for biobehavioral HIV prevention. This study will test individualized and group-based peer-delivered population- specific strategies to increase PrEP uptake and prevent HIV acquisition in trans MSM. The proposed research fills critical knowledge gaps in biomedical HIV prevention efforts for trans MSM, advances the science of peer- engaged approaches, and addresses national priorities in the 2021-2025 US National Strategic Plan to End the HIV epidemic.

PI_NAMEs: REISNER, SARI  (contact)

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: acceptability and feasibility;Address;Adult;AIDS prevention;American;Area;Behavior;Behavior Therapy;Behavioral;behavioral construct;biobehavior;Biological;Biological Markers;Birth;Black race;Blood;Chlamydia;cisgender;Clinical;Communities;comparative efficacy;Computerized Medical Record;Data;Decision Making;design;digital;digital delivery;Digital Libraries;Diphosphates;Dryness;efficacy trial;empowerment;emtricitabine;Ensure;Epidemic;experience;Female;Future;Gender;gender affirmation;Gender Identity;Geography;Goals;Gonorrhea;Health;health care availability;health care service;health disparity populations;Healthcare;HIV;HIV risk;HIV Seronegativity;implementation intervention;improved;Incidence;Individual;interest;Internet;Intervention;Interview;Knowledge;Latinx;Life;male;Measures;Mediating;Mediation;men;men of color;men who have sex with men;Mental Health;Methods;Modeling;Motivation;open label;peer;penis;Persons;Pilot Projects;Population;Populations at Risk;pre-exposure prophylaxis;prevent;Prevention;Prevention strategy;preventive intervention;primary outcome;Public Health;Randomized;recruit;Regimen;Research;Risk;Sampling;scale up;Science;Self Administration;self testing;Services;sex;Sex Behavior;Sexual Health;skills;social stigma;Spottings;standard of care;Strategic Planning;Surveys;Syphilis;Tenofovir;Testing;Testosterone;transgender;transgender men;transmasculine;tripolyphosphate;United States National Institutes of Health;uptake;US State;Work

PROJECT_TITLE: Strategies to Prevent HIV Acquisition Among Transgender MSM in the US

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Genetics

ORG_CITY: EAST LANSING

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: NARRATIVE This project focuses on largely unexplored mechanisms that multicellular eukaryotes have evolved to grow and protect themselves from death and diseases caused by insufficiency and defects in secretory protein synthesis. To achieve our goals, we will harness the power of the genomic resources and molecular tools of the model plant species Arabidopsis thaliana, which allow genetic and advanced analyses that are impossible to perform in humans and whole-body mammalian models. By studying the signaling pathways of conserved sensors that monitor the homeostasis of secretory protein synthesis, this work will reveal new mechanisms that coordinate growth, stress responses and cell fate decisions and thus improve our understanding of human growth and disease.

PI_NAMEs: BRANDIZZI, FEDERICA  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Address;Biological;biological adaptation to stress;Biological Models;Body System;Cell Death;Cell Death Process;Cell Differentiation process;Cell Line;Cells;Cessation of life;Chronic;Defect;design;Diabetes Mellitus;Disease;Effector Cell;Endoplasmic Reticulum;endoplasmic reticulum stress;environmental stressor;Eukaryota;forward genetics;frontier;Genetic;genetic resource;Genetic Screening;genome resource;Goals;Growth;Homeostasis;Housekeeping;Human;improved;In Vitro;in vivo;Knowledge;Life;Link;Malignant Neoplasms;Medical;Membrane;misfolded protein;model organism;Modeling;Molecular;Monitor;Mouse-ear Cress;Nerve Degeneration;novel;Organism;Pathway interactions;Phosphorylation;Physiological;Plant Model;Plants;Production;Protein Biosynthesis;protein folding;Protein Kinase;Proteins;Research;Resistance;response;Ribonucleases;Role;secretory protein;sensor;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Stress;targeted treatment;therapeutically effective;tool;transcription factor;Work

PROJECT_TITLE: Unfolded protein response in the model species Arabidopsis thaliana

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Aging;Biotechnology;Genetics

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project narrative  Disruption of genomic regulation is accompanied by striking functional changes across cell types and species. However, how mobile genetic elements are regulated throughout life, across biological sexes, and how they influence physiology in response to external or internal cues, remains largely unknown. By leveraging big data and state-of-the-art experimental approaches on vertebrate models including mouse and the emerging African turquoise killifish, the proposed research program will advance our understanding of mobile genetic element control in healthy somatic cells, and shed light on how these elements can influence vertebrate health and disease. 1

PI_NAMEs: BENAYOUN, BERENICE ANATH (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Adult;African;age related;Aging;Animal Model;Antibodies;Big Data;biological sex;Biology;cell type;Cells;cost effectiveness;Cues;Data;Development;Disease;DNA Transposable Elements;Elements;Family;Female;functional decline;functional genomics;Generations;Genetic;Genome;Genomics;Goals;Gonadal Hormones;Health;Homeostasis;Jumping Genes;Junk DNA;Killifishes;Laboratory mice;Life;life span;Link;Machine Learning;male;Malignant Neoplasms;Mobile Genetic Elements;model organism;Modeling;Mus;Nature;Nerve Degeneration;Organism;Parasites;Pattern;Physiology;prevent;programs;Regulation;Research;response;sex;Sex Chromosomes;sexual dimorphism;Somatic Cell;Time;Tissues;Validation

PROJECT_TITLE: Understanding the regulation and impact of transposable elements in Vertebrate health and disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative One of the most intriguing questions in science is how developmental pattern formation is executed so robustly despite unavoidable cell-to-cell variability in gene expression. We will investigate the mechanisms buffering this variability during vertebral segmentation. We will also elucidate how the transcriptome-level reorganization (expression levels and variability of thousands of genes) is controlled by cell signaling gradients. These information will be significant for understanding and potentially preventing vertebral malformations.

PI_NAMEs: OZBUDAK, ERTUGRUL M (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Anterior;Biochemical Reaction;Body Size;Buffers;Cell Count;cell growth;Cell Size;Cells;Characteristics;Chemicals;Complex;Congenital Abnormality;Development;Developmental Process;dosage;Embryo;Exhibits;Family;Feedback;Gene Expression;gene regulatory network;Genes;Genetic;Goals;Kinetics;Ligands;malformation;Mathematics;Mesoderm;Noise;notch protein;Pattern Formation;Periodicity;Phase;Phenotype;Population;prevent;programs;Reproducibility;Science;Segmentation Clock Pathway;Signal Transduction;Somites;somitogenesis;spine bone structure;Statistical Models;Stochastic Processes;System;Tail;Time;transcriptome;Tretinoin

PROJECT_TITLE: Regulatory Mechanisms Governing Precision in Vertebral Segmentation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Chronic Pain;Clinical Research;Complementary and Integrative Health;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Controversy exists over the risk to benefit ratio of medical marijuana for adults with chronic non-cancer pain (CNCP) on chronic opioid therapy (COT). The primary goal of this proposal is to assess whether medical marijuana, when added to a behavioral prescription opioid taper support program, improves pain and reduces opioid dose in adults on COT for CNCP more so than the behavioral intervention alone. This information is critical to better inform patients and clinicians about the extent to which medical marijuana use may be beneficial or harmful to this patient population.

PI_NAMEs: EVINS, A EDEN;GILMAN, JODI  (contact)

PROGRAM_OFFICER_NAME: WANG, JIA BEI

PROJECT_TERMS: Address;Adjuvant Therapy;Administrative Supplement;Adult;Anxiety;Attention;Behavior Therapy;Behavioral;Benefits and Risks;Cannabis;Chronic;chronic pain management;cognitive function;Complex;Development;Dose;Effectiveness;Enrollment;executive function;functional status;Goals;Health Personnel;improved;interest;Manuals;marijuana use;Medical;Medical Marijuana;Mental Depression;non-cancer chronic pain;Numeric Rating Scale;Opioid;opioid mortality;opioid tapering;opioid therapy;opioid use;opioid use disorder;Pain;Pain interference;pain patient;painful neuropathy;Participant;patient population;Patients;Performance;Pharmaceutical Preparations;Policy Maker;Population;prescription opioid;primary outcome;programs;Public Health;Quality of life;Randomized;Reporting;Risk;Severities;Short-Term Memory;Site;United States;Urine;Visit;Waiting Lists

PROJECT_TITLE: Administrative Supplement: Medical Marijuana, Pain, and Opioid Use in Patients with Chronic Non-cancer Pain

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Endocannabinoid System Research;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Prevention;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: Project Narrative Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are highly comorbid and individual differences in response to stress suggest resilient and susceptible populations, which may be important for understanding this high comorbidity. The proposed work will examine neural circuitry and mechanisms that drive adaptive vs. maladaptive coping strategies during stress and the relation to subsequent alcohol drinking. Understanding the neurobiological mechanisms that underlie stress coping and maladaptive alcohol drinking may provide more effective-and sex-specific clinical prevention and treatment strategies for individuals with PTSD and comorbid alcohol use.

PI_NAMEs: ORNELAS, LAURA C. (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: 2-arachidonylglycerol;2-arachidonylglycerol signaling;Alcohol abuse;alcohol comorbidity;Alcohol consumption;alcohol use disorder;Alcohols;Amygdaloid structure;Animal Model;Automobile Driving;behavioral outcome;behavioral pharmacology;behavioral response;Brain;career;Cells;Clinical;CNR1 gene;comorbidity;coping;Coping Behavior;Coping Skills;Data;Development;Electrophysiology (science);endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;experience;Exposure to;Failure;Female;Foundations;Future;Genetic;genetic approach;Goals;Immobilization;Immunohistochemistry;in vivo;Individual;Individual Differences;job market;Label;Learning;liquid chromatography mass spectrometry;MAGL inhibitor;maladaptive behavior;male;Measures;Medial;Mediating;men;Methods;Modeling;Molecular;neural circuit;neuroadaptation;neurobiological mechanism;neuromechanism;neuronal excitability;Neurons;Neurosciences;Odors;optogenetics;Pathway interactions;Phase;Population;Post-Traumatic Stress Disorders;Predisposition;Prefrontal Cortex;prevent;Prevention strategy;Rattus;reduce symptoms;Research;resilience;response;Risk;Role;Self Administration;sex;Sex Differences;Signal Transduction;Site;skills;Stress;Stress and Coping;Stressful Event;stressor;Subgroup;Techniques;Testing;theories;Training;Trauma;traumatic stress;treatment strategy;Woman;Work

PROJECT_TITLE: Corticolimbic circuitry in adaptive stress coping behavior and subsequent alcohol drinking


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: ITHACA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE  Monitoring antimicrobial use in dairy cattle is imperative to facilitate data-driven antimicrobial stewardship and better understand the relationships between antimicrobial use in animals and antimicrobial resistance. This project aims to collect multiple years of detailed antimicrobial use data on dairy farms, develop an antimicrobial use monitoring system with features that incentivize farmer participation, and improve the understanding of farmers' perceptions and needs concerning antimicrobial use monitoring. Such a system will incentivize dairy farmer participation and enable One Health to benefit from national-level antimicrobial use monitoring.

PI_NAMEs: IVANEK MIOJEVIC, RENATA  (contact)

PROGRAM_OFFICER_NAME: HUEBNER, KATHERINE

PROJECT_TITLE: A System Approach to Animal-Level Antimicrobial Use Monitoring in Dairy Cattle

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CVM-T (04)]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Researchers-in-training in biomedical fields, particularly those from underrepresented groups, contend with a number of barriers to their career success. In the proposed project, we plan to address the Triple Threat to trainees’ career success (impostor phenomenon, fixed mindset, and perceived discrimination) by developing and testing dual interventions—one for trainees and one for their mentors—that directly target and mitigate these threats. These dual interventions, which will not only address trainees’ coping skills but will also foster environmental change via their mentors and training program directors also trained to deliver the interventions, are designed to be scalable and sustainable over time, with the goal of increasing retention of all underrepresented groups in the biomedical research pipeline.

PI_NAMEs: CHANG, SHINE  (contact);COKLEY, KEVIN O

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Academic achievement;Achievement;active control group;Address;African American population;Alaska Native;American Indians;Anxiety;Area;Awareness;Behavior;Behavioral;Belief;Biomedical Research;Black American;career;Career Choice;Categories;Color;Competence;Complementary therapies;coping;Coping Skills;Country;Demographic Factors;demographics;design;Development;disadvantaged background;disadvantaged student;doctoral student;educational atmosphere;Educational process of instructing;Educational workshop;empowerment;Environment;environmental change;Expectancy;expectation;experience;Feeling;Fostering;Fright;Funding;Goals;Grant;Growth;Health Sciences;Hispanic Populations;Hour;improved;innovation;Institution;Intelligence;interest;Intervention;Latino Population;Lead;Learning;Link;Measures;Mentors;Mentorship;Minority Groups;minority trainee;Modeling;Motivation;multilevel analysis;National Institute of General Medical Sciences;Native Hawaiian or Other Pacific Islander;Outcome;perceived discrimination;post intervention;Postdoctoral Fellow;psychosocial;Qualifying;Randomized;recruit;Reporting;Research;Research Design;Research Personnel;Research Training;Resources;Science;Scientist;Self Efficacy;Shapes;Site;skills;Student Persistence;student retention;Students;study population;success;Testing;Time;Time Management;tool;Training;Training Programs;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;United States National Institutes of Health;virtual;Work

PROJECT_TITLE: Overcoming the triple threat to diversity in the health science workforce: empowering the next gen.


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE We hypothesize that mutant p53 enhances inflammatory stress via activating the NLRP1 inflammasome and increasing the secretion of proinflammatory cytokines, thereby generating a chronic inflammatory microenvironment that inhibits wild type (WT) hematopoietic stem and progenitor cell (HSPC) fitness in a paracrine fashion. We further speculate that reducing chronic inflammation will prevent or delay the progression of TP53 mutant clonal hematopoiesis to myelodysplastic syndromes (MDS).

PI_NAMEs: LIU, YAN  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Age;aged;Bacterial Infections;Blood;Cells;Chronic;Clinical Research;cytokine;Development;Dysmyelopoietic Syndromes;EZH2 gene;fitness;Funding;Hematologic Neoplasms;Hematopoiesis;Hematopoietic stem cells;Individual;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Interleukin-1 beta;Interleukin-6;Knowledge;mutant;Mutant Strains Mice;Mutate;Mutation;Myeloproliferative disease;novel strategies;paracrine;parent grant;prevent;Risk;stem cell expansion;Stress;Testing;TP53 gene

PROJECT_TITLE: Diversity Supplement to R01 Parent Grant HL150624


NIH_SPENDING_CATS: Data Science

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: NARRATIVE The GlyGen knowledgebase plans to continue its evolution into an essential resource for glycobiology and related domains through integration, harmonization, and annotation of data describing glycan and glycoconjugate dynamics in health and disease.

PI_NAMEs: MAZUMDER, RAJA ;TIEMEYER, MICHAEL  (contact)

PROJECT_TITLE: Administrative Supplement - GlyGen growth and evolution into a central resource for glycans and glycoconjugates

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: PROJECT NARRATIVE (RELEVANCE) The proposed research is relevant to public health in that it aims to create a software infrastructure that will facilitate evaluation of cognition associated with cognitive interventions and other longitudinal studies assessing cognitive abilities. This research is aligned with the NIH mission of improving health and well-being of older adults who may be at risk to develop Alzheimer's disease and Alzheimer's disease and related dementias (AD/ADRD), in that it seeks to facilitate better measurement and comparisons of measurements of cognition in older adult population. Thus, the proposed research cuts across the bounds of numerous NIH agencies, with our framework contributing to the missions of the NIA, NCI, NEI, NIMH, NIAAA, NINCD, NIDA, NINDS, in that all of these agencies work with populations who can gain direct benefits from successful approaches to mental fitness, and the NIH's greater mission to seek knowledge that will result in enhanced health and a reduced burden of disabilities.

PI_NAMEs: ANGUERA, JOAQUIN A;JAEGGI, SUSANNE M;SEITZ, AARON R (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Assessment tool;Award;Basic Science;Binding;Brain;Calibration;Cellular Phone;Clinical;cloud based;Cognition;Cognitive;cognitive ability;cognitive control;cognitive system;cognitive testing;cognitive training;Communities;Computer software;Custom;Data;data visualization;Diagnostic;disability burden;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Enrollment;Evaluation;experience;Face;fitness;flexibility;functional decline;Future;Goals;Grant;handheld mobile device;Health;Health Insurance Portability and Accountability Act;Health Personnel;Hearing;Impaired cognition;improved;Industry;Infrastructure;Intelligence;interoperability;Intervention;Knowledge;Libraries;Light;Liquid substance;Literature;Longitudinal Studies;Measurement;Measures;Methods;migration;mindfulness;Mission;Modernization;Monitor;Music;National Institute of Drug Abuse;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;National Institute on Alcohol Abuse and Alcoholism;novel;older adult;Outcome;Outcome Measure;Participant;Personal Satisfaction;Phase;Physiological;Population;Procedures;Proliferating;prototype;Psyche structure;Psychometrics;Public Health;recruit;Research;Research Personnel;Research Project Grants;research study;Research Training;Rest;Risk;Risk Assessment;Running;Scientist;Security Measures;sensor;Services;Short-Term Memory;Site;Societies;software development;software infrastructure;software systems;sound;Standardization;System;Systems Development;Tablets;Technology;Testing;Time;tool;Training;Translating;translational approach;Translations;Underserved Population;United States National Institutes of Health;Validation;Vision;visual tracking;Work

PROJECT_TITLE: Building a shared infrastructure for cognitive assessment in the service of cognitive training research


ORG_CITY: FALCON HEIGHTS

ORG_NAME: MINDWALK CONSULTING GROUP, LLC

ORG_STATE: MN

PHR: Project Narrative Antimicrobial use (AMU) is the primary selective force behind the emergence of resistant bacteria, and systems must be developed for collecting on-farm AMU data. This project will expand an ongoing, nationally-representative and sustainable system for collecting on-farm quantitative antimicrobial use data in the broiler chicken, turkey, and table egg industries of the U.S. This project will also address key data gaps that we have identified during our 10-year effort of collect data from the majority of annual U.S. poultry production.

PI_NAMEs: SINGER, RANDALL S (contact)

PROJECT_TITLE: Antimicrobial Use Data Collection in the U.S. Poultry Production System


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences

ORG_CITY: Aurora

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: This Project Narrative was originally submitted with R01 NS114430 and is included here unchanged to satisfy submission system requirements. NARRATIVE Skilled movement is believed to emerge from the learned dynamical patterns of neural activity in motor control brain regions. However, movement related activity in the cerebellar neurons is best understood at the cellular level. Therefore, we will test the hypothesis that cerebellar Purkinje cells also employ a population code that synergizes spike rate modulation and synchronous firing to produce robust disinhibition of recipient neurons in the cerebellar nuclei leading to kinematic alterations of learned, dexterous motor behaviors.

PI_NAMEs: CHRISTIE, JASON M;CHRISTIE, JASON M (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Behavior;Behavioral;Brain region;Cell Nucleus;Cerebellar Cortex;Cerebellar Diseases;Cerebellar Nuclei;Cerebellum;Code;Disinhibition;Dysmetria;Functional disorder;Future;Goals;kinematics;Learning;learning engagement;Limb structure;Location;Mediating;Modeling;motor behavior;motor control;motor learning;Movement;Mus;Nature;neural patterning;Neurons;Nuclear;Output;Population;Process;Public Health;Purkinje Cells;Signal Transduction;skills;Structure;synergism;System;targeted treatment;Testing;transmission process

PROJECT_TITLE: Circuit mechanisms of cerebellar control of reaching movements


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: PROJECT NARRATIVE HIV-1 does not replicate in macaques, and thus chimeric simian-human immunodeficiency viruses (SHIVs) are used as surrogates to study HIV-1 infection in macaques. However, most SHIVs fail to replicate in macaques unless they are extensively adapted via serial macaque passage, which is an expensive and labor-intensive process. This study will characterize the viral and host determinants of adaptation of SHIVs to macaques, which will facilitate rational design of SHIVs that do not require extensive adaptation.

PI_NAMEs: SHARMA, AMIT  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Affect;Binding;Binding Sites;Biological;Biological Models;CD4 Positive T Lymphocytes;Cells;chronic infection;Data;Development;efficacious intervention;Genes;Glycoproteins;Goals;HIV Infections;HIV-1;Homologous Protein;Human;Immune;improved;In Vitro;in vivo;Infection;insight;Integral Membrane Protein;Integration Host Factors;Interferon Type I;Interferons;Laboratories;Link;Lymphocyte;Macaca;Macrophage;Maps;memory CD4 T lymphocyte;Modeling;Molecular Conformation;monocyte;Mucous Membrane;Mutation;neutralizing antibody;non-Native;Pathogenicity;Polysaccharides;prevent;Prevention;Process;Production;Proteins;rational design;Rectum;Research Proposals;Resistance;response;Role;Serial Passage;simian human immunodeficiency virus;SIV;Structure;T-Lymphocyte Subsets;Time;transmission process;Vaccines;Variant;Viral;Virion;Virus;Virus Diseases;Virus Replication;virus tropism

PROJECT_TITLE: Determinants of retroviral replication in non-native hosts for modeling HIV infection

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Disability Research;Lung;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: MILWAUKEE

ORG_DEPT: NEUROSURGERY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: PROJECT NARATIVE: This diversity supplement is requested to support the scientific and career training of Ms. Allison Brezinski, a promising PhD candidate whose long-term goal is to become an independent neuroscience investigator. Ms. Brezinski’s independent research project examining the role of Dorsal type-3 interneurons (dI3 INs) in respiratory circuity and recovery in degenerative cervical myelopathy expands on the parent grant’s goal of investigating dI3 INs in neural circuity and recovery of fine motor movement in DCM. The training and mentorship provided to Ms. Brezinski under this supplement will be valuable to her development as a scientist, and an instrumental step in her achieving her professional and personal goals of becoming an independent academic researcher.

PI_NAMEs: SATKUNENDRARAJAH, KAJANA  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;Adult;Affect;Anatomy;Anesthesia procedures;Anesthetics;Award;Brain Stem;Breathing;Carbon Dioxide;career;Cell Nucleus;Cervical;Cervical spinal cord injury;Cervical spine;chronic pain;Collaborations;Data;debilitating symptom;Development;disability;Doctor of Philosophy;Dorsal;efficacy evaluation;Exercise;experience;Forelimb;functional improvement;functional outcomes;functional plasticity;Future;Gait;Gait abnormality;Genetic;Goals;grasp;hand dysfunction;Health;Hour;Hypercapnia;Impairment;improved;Individual;Institution;Interneurons;Investigation;Knowledge;Lead;Leadership;Mentorship;Motor;motor control;Motor Cortex;Motor Neurons;motor recovery;mouse model;Movement;Muscle;Nervous System Disorder;neural;neural circuit;neural network;Neurologic;neurological recovery;Neurons;neuroregulation;Neurosciences;Operative Surgical Procedures;Pain;parent grant;Pathologic;Patient Care;Patient-Focused Outcomes;Patients;Peripheral;Qualifying;Recovery;Recovery of Function;Research;Research Personnel;Research Project Grants;Respiration Disorders;respiratory;respiratory challenge;Respiratory Diaphragm;Respiratory Tract Infections;response;Role;Scientist;Sensory impairment;sensory input;skills;Spinal;Spinal Cord;spinal cord compression;Spinal Cord Diseases;Spinal cord injury;Stress;Surgical Decompression;Symptoms;Synapses;Testing;Training;Upper Extremity;Vertebral column;Viral

PROJECT_TITLE: Dissecting spinal interneuron circuits to augment neurological recovery in Degenerative Cervical Myelopathy (DCM)


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Prevention;Substance Misuse

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative The NIH created the Helping to End Addiction Long-term (HEAL) initiative to speed scientic solutions to the national opioid public health crisis. As part of the HEAL initiative, the HEAL Effectiveness Research Network (ERN) was established to conduct comparative effectiveness trials for prevention and management of pain, while reducing risk of addiction. The University of Utah will provide data coordination support for these trials, leading to more effective management of acute and chronic pain while reducing the risk of opioid addiction.

PI_NAMEs: DWYER, JAMIE P.;SWARD, KATHERINE ANN;WATT, KEVIN M (contact)

PROGRAM_OFFICER_NAME: VALLEJO, YOLANDA F

PROJECT_TERMS: Acute pain management;addiction;Administrative Supplement;chronic pain;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Network;Collaborations;Collection;Common Data Element;comparative effectiveness trial;cost;Data;Data Analyses;Data Collection;data ecosystem;data management;Data Set;data sharing;Databases;Deposition;design;Development;Dose;effectiveness research;Helping to End Addiction Long-term;Institutional Review Boards;Leadership;Monitor;Opiate Addiction;Opioid;Pain;Pain management;Preparation;prevention effectiveness trial;programs;Protocols documentation;Public Health;Publications;Quality Control;Randomized;Regimen;Reporting;repository;Research Personnel;Resources;Risk Assessment;Risk Reduction;Speed;success;System;Training;Translational Research;United States National Institutes of Health;Universities;Utah;Work;Writing

PROJECT_TITLE: HEAL ERN: Data Coordinating Resource Center


ORG_CITY: EVANSTON

ORG_NAME: SIBEL INC.

PHR: PROJECT NARRATIVE Wireless monitoring with small, noninvasive sensors for Parkinson’s patients with dysphagia would allow for objective monitoring of swallow and respiratory coordination in their naturalistic environment. This proposal centers on technical verification and clinical testing to fit the major needs in drug development for these novel wireless sensors.

PI_NAMEs: XU, SHUAI  (contact)

PROGRAM_OFFICER_NAME: TOMITA, YORK

PROJECT_TITLE: DDT-COA-000167: Digital Sensor for Monitoring Swallow Count and Respiratory Coordination in Parkinson’s Disease patients with Dysphagia

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CDER-T (18)]


ORG_CITY: MANHATTAN

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: Project Narrative: Leveraging the extensive database of FARAD and advanced analytics of the 1DATA consortium, this project aims to develop the Long-term Antimicrobial Use with AI web-crawler (LAMU-AI) to revolutionize antimicrobial stewardship in veterinary medicine. By integrating multiple data sources and deploying sophisticated visualization tools, LAMU-AI will provide real-time insights into antimicrobial usage trends across diverse animal populations, enabling informed decision- making for stakeholders. Through collaboration with FARAD scientists and veterinary experts, we seek to address critical data gaps and enhance our understanding of antimicrobial deployment patterns to combat antibiotic resistance effectively.

PI_NAMEs: JABERI-DOURAKI, MAJID  (contact)

PROJECT_TITLE: Bridging Critical Data Gaps in Veterinary Medicine Via Artificial Intelligence and Advanced Large Language Models to Procure Real-Time Antibiotic Use Data in Livestock, Poultry and Companion Animals


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric;Prevention

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: Project Narrative How infants learn to progress from spontaneous and seemingly disorganized movements into goal-directed and refined motor skills is unknown. Until we understand how to promote successful infant learning, we cannot design optimal early intervention for infants with or at risk of neuromotor developmental disabilities. The objectives of this project are to 1) determine the relationship between error rate and the development of reaching skill in infants with typical development, 2) identify individual and environmental factors related to the development of skilled reaching in infants with typical development, 3) identify patterns of concurrent brain activity that differentiate between spontaneous arm movements, early reaching attempts, and skilled reaches in infants with typical development, and 4) identify patterns of concurrent brain activity that differentiate between spontaneous arm movements, early reaching attempts, and skilled reaches in infants at high risk for cerebral palsy.

PI_NAMEs: SMITH, BETH A (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Age;Age of Onset;arm;arm movement;Behavior;Bilateral;Brain;Caregivers;Cerebral Palsy;Characteristics;cognitive development;Data;design;Development;Developmental Disabilities;Early Intervention;Education;Electroencephalography;Environmental Risk Factor;experience;Goals;high risk;Home;Impairment;Individual;infancy;Infant;Intervention;intervention program;Learning;Longitudinal Studies;Measures;Motor;motor control;Motor Skills;Movement;neural;nutrition;Parietal;Pattern;Perception;Population;Predictive Factor;preference;Process;Rest;Risk;skill acquisition;skills;Sleep;Source;theories

PROJECT_TITLE: Emergence of arm reaching behavior and lateralization of motor control in infancy


ORG_CITY: BOSTON

ORG_NAME: EMULATE, INC.

PHR: RFA-FD-24-030 Application Identifier: 1690535 Project Narrative: Emulate has submitted a Letter of Intent (LOI; DDT-IST-000016-LOI-2) that describes the above-mentioned context of use (pairwise DILI risk comparisons) and argues that the Liver-Chip is suitable as a drug development tool (DDT) for this use-case. The submission uses data derived from Ewart et al., 2022, to illustrate that the Liver-Chip provides sufficient accuracy to facilitate pairwise DILI risk comparisons by examining 12 FDA-approved drugs with known clinical DILI profiles. However, the suitability of the Liver-Chip to the described context of use would also benefit from a demonstration of the (inter-lab) reproducibility and (intra-lab) repeatability of the DDT as well as testing across a broader panel of human hepatocyte donors. 27 Drydock Avenue, 5th Floor Boston, MA 02210

PI_NAMEs: EWART, LORNA  (contact)

PROJECT_TITLE: DDT-IST-000016-LOI-2 A Human Liver-Chip for Prediction of Drug-Induced Liver Injury proposed for context of use claim for the prediction of DILI within preclinical drug development program


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Children with autism spectrum disorder who receive intervention earlier in life show larger gains in language skills and improved overall development; presymptomatic intervention during infancy may soon be feasible because recent research advances have lowered the age of possible detection to 6-months. The proposed study will inform future presymptomatic interventions by identifying infant-based language and communication risk markers, caregiver-based intervention targets, and brain-based monitoring biomarkers. The objectives of this proposal align with the NIDCD Strategic Plan Priority Areas in Voice, Speech, and Language Research by: 1) understanding diseases and disorders; 2) improving diagnosis, treatment, and prevention; and 3) improving outcomes for human communication.

PI_NAMEs: SWANSON, MEGHAN RAE (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Adult;Age;Age Months;Area;autism biomarker;Autism Diagnosis;autism spectrum disorder;autism symptoms;autistic children;Axon;Biological Markers;Brain;brain based;brain behavior;Brain region;care costs;Caregivers;Child;Classification;clinical practice;Collaborations;Communication;Companions;Crying;Data;Detection;Development;Diagnosis;Diagnostic;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Distress;Early Intervention;economic cost;evidence base;Exposure to;forging;Funding;Future;Goals;Growth;Hearing;high risk;high risk infant;Home;Human;Image;improved;improved outcome;individuals with autism spectrum disorder;infancy;Infant;Infant Development;Intervention;intervention effect;Intervention Studies;Knowledge;Language;Laughter;Length;lexical;Life;Linguistics;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;meetings;Monitor;National Institute on Deafness and Other Communication Disorders;neurodevelopment;Neuronal Plasticity;Outcome;Parents;peer;Play;Predisposition;prefrontal lobe;Prevention;Probability;protective effect;public health relevance;Research;Research Personnel;Risk;Risk Marker;Sampling;Siblings;skills;social communication;Specific qualifier value;Speech;Strategic Planning;Structure;Temporal Lobe;Time;Treatment Efficacy;United States National Institutes of Health;Validation;vocalization;Voice;white matter;Work

PROJECT_TITLE: Caregiver Speech and Brain-Behavior Development in Infants At-Risk for ASD

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative The brain regulates reproductive function and fertility through the release of gonadotropin-releasing hormone (GnRH), and defects in neural mechanisms that govern the normal pulsatile GnRH release pattern are invariably associated with reproductive disorders such as absent, delayed, or precocious puberty, functional hypothalamic amenorrhea, or polycystic ovary syndrome. The proposed studies will utilize innovative new animal models to determine the mechanisms by which a network of neurons producing the neuropeptide kisspeptin synchronously activate GnRH neurons as a functional “kisspeptin-GnRH pulse generator”. By providing fundamental information on the cellular circuitries that produce pulsatile GnRH release, the proposed studies will shed new light on the pathophysiologic mechanisms underlying neuroendocrine-based fertility disorders and point to new potential targets for intervention in these reproductive impairments.

PI_NAMEs: LEVINE, JON E;RADOVICK, SALLY  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Acceleration;Adult;Adult Children;Adult women;Alleles;Animal Model;Animals;autocrine;Axon;Blood Vessels;Brain;Breeding;Cell Nucleus;Cells;Central Nervous System;Defect;Delayed Puberty;Development;Doxycycline;dynorphin receptor;Dynorphins;Elements;Enterobacteria phage P1 Cre recombinase;ESR1 gene;Estradiol;Estrogen Receptor 2;Feedback;Female;Fertility;Fertility Disorders;Follicle Stimulating Hormone;functional hypothalamic amenorrhea;Gene Deletion;Gene Modified;Generations;Genetic;Genetic Recombination;GNRH1 gene;gonad function;Gonadal Steroid Hormones;Gonadotropin Hormone Releasing Hormone;Gonadotropins;Hormone secretion;Hypothalamic structure;Impairment;inducible Cre;Infertility;innovation;Internal Ribosome Entry Site;Intervention;kappa opioid receptors;KISS1 gene;Knock-out;knockout gene;Laboratories;Luteinizing Hormone;male;mature animal;median eminence;Mediating;Methodology;Modeling;mouse model;Mus;Neurokinin B;neuromechanism;Neurons;Neuropeptides;Neurosecretion;Neurosecretory Systems;novel;Optics;paracrine;Partner in relationship;Pattern;Peptides;Periodicity;Phenotype;Physiologic pulse;Play;Polycystic Ovary Syndrome;Population;Precocious Puberty;preoptic nucleus;Process;prodynorphin;Puberty;receptor;receptor binding;Regulation;reproductive;reproductive axis;reproductive function;reproductive system disorder;Role;Steroid Receptors;Steroids;Structure of nucleus infundibularis hypothalami;Synapses;System;TACR3 gene;Testing;tool;Ventricular

PROJECT_TITLE: Sex Steroids, Kisspeptin and Regulation of GnRH

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Project Narrative: An in depth understanding of the novel signaling molecules and pathways in platelets will help us understand how signaling pathways are regulated in other cells. Understanding these signaling cascades in platelets will help us evaluate and predict possible implications of the therapeutic agents that could interfere with these pathways.

PI_NAMEs: KUNAPULI, SATYA P. (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Age;Applications Grants;Atherosclerosis;Blood flow;Blood Platelets;Blood Vessels;Cells;Chronic Lymphocytic Leukemia;Diabetes Mellitus;Disease;Environment;Event;Focus Groups;Funding;Genetic;Goals;Hemostatic function;Inflammation;insight;kinase inhibitor;Lesion;lymphatic vessel;Malignant Neoplasms;Mediating;MicroRNAs;new therapeutic target;novel;Paper;Pathway interactions;Platelet Activation;platelet function;Play;Predisposition;Protein Kinase;Protein Tyrosine Kinase;Publishing;Reagent;receptor;receptor-mediated signaling;Regulation;Research;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Surface;System;TEC Protein Tyrosine Kinase;Therapeutic Agents;Thrombocytopenia;Thrombosis;thrombotic;tool;Tyrosine Phosphorylation;United States National Institutes of Health;Work

PROJECT_TITLE: Novel signaling molecules regulating platelet activation


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE A majority of the women in Kenya, who are not pregnant, breastfeeding, or seeking family planning services are often missed by the current cervical cancer screening initiatives integrated in these special clinics providing such services. Outpatient emergency departments present an opportunity to reach many women at the initial point of contact with the health care system. This project seeks to understand the acceptability, barriers, and facilitators to integrating cervical cancer screening into the existing outpatient emergency departments and will provide important insights into its feasibility allowing the formulation and adaptation of strategies to promote its implementation in many outpatient clinics in Kenya and other LMICs with low cervical cancer screening.

PI_NAMEs: CHUNG, MICHAEL HOONBAE (contact);KINUTHIA, JOHN

PROGRAM_OFFICER_NAME: HANISCH, RACHEL ANN

PROJECT_TERMS: Accident and Emergency department;Acetic Acids;Administrative Supplement;Africa South of the Sahara;Ambulatory Care Facilities;Award;Breast Feeding;Cancer Etiology;Caring;Cervical;cervical cancer prevention;Cervical Cancer Screening;Cessation of life;Charge;Clinic;Communities;Complement;Comprehensive Health Care;Consolidated Framework for Implementation Research;Country;County;Data;demographics;design;Early Diagnosis;Educational workshop;effective therapy;Epithelial Cells;falls;Family Planning;Formulation;Grant;grasp;Guidelines;Gynecologist;Health care facility;Health Personnel;Health Planning;Healthcare Systems;High Prevalence;HIV;Hospitals;Human Papillomavirus;implementation science;implementation strategy;Income;insight;interest;Interview;Iodine;Kenya;lecturer;Lesion;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maternal and Child Health;Mentors;Mentorship;mortality risk;National Cancer Program;Oncology;outpatient facility;Outpatients;Pap smear;premalignant;preventable death;prevention service;Primary Care;Primary Health Care;Recommendation;Research;Research Project Grants;Research Training;response;screening;Screening for cancer;screening guidelines;screening services;Services;Site;skills;Surveys;Testing;Training;Universities;uptake;Visual;Woman;women's diagnosis;Women's mortality

PROJECT_TITLE: Integrating cervical cancer screening within the outpatient emergency departments in Kenya


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Rural Health;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: NARRATIVE Children and adolescents who reside in rural regions of the United States experience substantially increased risks of mental and behavioral health conditions, suicide, and firearm-related deaths, and also experience unique barriers to care given geographic isolation and shortages of mental health professionals. This research will develop, implement, and evaluate technology-assisted, culturally sensitive safety planning in rural emergency departments for youth with suicidal ideation or attempt and their caregivers, aiming to improve home safety and connections to community-based resources and ultimately decrease youth suicide risk.

PI_NAMEs: LEYENAAR, JOANNA  (contact)

PROGRAM_OFFICER_NAME: AKUBU-ODERO, MAUREEN KALAMBU

PROJECT_TERMS: 17 year old;Acceleration;acceptability and feasibility;Accident and Emergency department;Address;Adolescent;Adoption;Adult;Attention;barrier to care;behavioral health;brief intervention;care seeking;Caregivers;Caring;Cessation of life;Child;child services;Childhood;Communities;community based participatory research;comparison intervention;coping;Coping Skills;Counseling;design;Development;Development Plans;digital decision aid;digital intervention;Discipline of Nursing;Education;Educational process of instructing;effectiveness evaluation;effectiveness/implementation study;Emergency Care;Emergency department visit;emotional distress;evidence base;expectation;experience;Face;Family;Feeling suicidal;firearm access;Firearms;Focus Groups;Funding;Geography;Goals;Guns;Health;health care availability;health equity promotion;Health Professional;Health Resources;Home;Hospitals;Human;hybrid type 1 trial;improved;improved outcome;instrument;Intervention;Interview;Licensing;Maintenance;Measures;Mediating;member;Mental Health;Mental Health Services;Methods;mortality;multidisciplinary;New Hampshire;Outcome;Ownership;Participant;peer;Pharmaceutical Preparations;Population;Poverty;preventive intervention;primary outcome;Procedures;programs;psychosocial;Qualitative Research;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recovery;reducing suicide;Reporting;Research;Research Design;Research Methodology;Research Personnel;Resources;Risk;Rural;rural area;Rural Hospitals;Rural Population;rural setting;Safety;Self Efficacy;Seminal;skills;social health determinants;social stigma;Social support;suicidal;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Tablets;Technology;Testing;treatment as usual;United States;urban disparity;Work;Youth

PROJECT_TITLE: Development and Implementation of Culturally Sensitive Safety Planning to Reduce Suicide Risk in Adolescents Seeking Care in Rural Emergency Departments

STUDY_SECTION_NAME: Special Emphasis Panel[ZNR1 REV-M (44)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Neurosciences;Osteoporosis

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: Narrative The nervous system has been implicated in age-related bone loss, but the underlying mechanisms through which it directly promotes bone resorption are understudied. The proposed work will test the outstanding mechanistic questions of how the nervous system directly influences bone, which could lead to new treatments for osteoporosis.

PI_NAMEs: MOTYL, KATHERINE JEAN (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Adrenergic Antagonists;Adrenergic beta-Agonists;Adrenergic beta-Antagonists;Age;Age-Related Bone Loss;Aging;aging related;Agonist;Albuterol;Alleles;Attenuated;beta-adrenergic receptor;Binding;Biological Assay;bone;Bone Density;Bone Diseases;bone loss;Bone Marrow;Bone remodeling;Bone Resorption;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcineurin;Calcineurin inhibitor;Cells;Clinical;Cohort Studies;Cyclic AMP-Dependent Protein Kinases;Data;Dose;Ensure;fracture risk;G Protein-Coupled Receptor Signaling;Genes;Genetic;Goals;Hand;Human;improved;In Vitro;in vivo;in vivo evaluation;Laboratories;Ligand Binding;Ligands;Marrow;Mass Spectrum Analysis;Mediating;Mediator;Meta-Analysis;monocyte;Mus;Myelogenous;Nervous System;novel;Nuclear;nuclear factors of activated T-cells;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteogenesis;Osteoporosis;Pathology;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Postmenopause;PPP3CA gene;preclinical study;prevent;Propranolol;prospective;receptor;Receptor Signaling;recruit;Refractory;Role;Serum;Signal Pathway;Signal Transduction;Sympathetic Nervous System;Testing;transcriptome sequencing;Woman;Work

PROJECT_TITLE: A novel cell-autonomous role for β-adrenergic receptor signaling in osteoclasts

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Precision Medicine

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PI_NAMEs: TOPOL, ERIC JEFFREY (contact);VOGEL, JULIA LOUISE MOORE

PROGRAM_OFFICER_NAME: MANDICH, ALLISON MARIE

PROJECT_TERMS: Acceleration;All of Us Research Program;Ancillary Study;Area;Artificial Intelligence;Biomedical Research;Blood;Categories;Childhood;Collaborations;Collection;Communities;Consent;cost;cultural competence;Data;Data Collection;data sharing;Decision Making;Dedications;Development;digital;empowerment;Enrollment;Ensure;Equity;Ethnic Origin;experience;Experimental Designs;Federally Qualified Health Center;Goals;Health;Healthcare;high reward;high risk;Impact evaluation;improved;Individual;Infrastructure;innovation;interest;Lead;Learning;Light;Measures;Mediating;Mission;multimodality;novel;novel strategies;opportunity cost;outreach;Participant;Persons;Population;Process;programs;Race;Recommendation;recruit;Research;Resources;response;retention rate;Review Literature;Risk;Saliva;success;Surveys;Technology;Testing;Touch sensation;United States;United States National Institutes of Health;Urine;Work

PROJECT_TITLE: The Participant Center: Empowering All of Us Research Program participation across the United States


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Prevention;Rare Diseases;Women's Health Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE One in 151 women in the United States carry the FMR1 premutation, a genetic abnormality that is associated with substantially increased risk for disease that appears to worsen at older ages. This longitudinal investigation of mother carriers of the FMR1 premutation aims to define age-related stability of symptoms in midlife and early old age, associated functional limitations, and the role of biological and environmental factors. Delineating the trajectory and predictors of age-related decline will inform critical age periods for prevention, risk factors, and the eventual development of strategies to improve age-related outcomes for both carrier mothers and their children with fragile X syndrome.

PI_NAMEs: KLUSEK, JESSICA  (contact)

PROGRAM_OFFICER_NAME: HOROWITZ, TODD S

PROJECT_TERMS: Acceleration;Activities of Daily Living;Adopted;Adult;Advocate;Affect;Age;age acceleration;age related;age related changes;age related decline;aged;Aging;aging process;Anxiety;Autoimmune;Autonomic Dysfunction;Autonomic nervous system;Biological;Biological Factors;Caring;Characteristics;Child;Child Rearing;chronic painful condition;Classification;Clinical;Clinical Management;clinical risk;Cross-Sectional Studies;Data;Development;disability;disorder risk;DNA Sequence Alteration;Environmental Risk Factor;Executive Dysfunction;executive function;experience;Eye;Family;FMR1 gene;FMR1 Premutation;Fragile X Syndrome;Functional disorder;Future;Gene Abnormality;Genes;Genetic;Genetic Predisposition to Disease;Genotype;Glean;Goals;Growth;Heart Rate;High Prevalence;human old age (65+);Impairment;improved;improved outcome;Individual;Infertility;innovation;International;Investigation;Life;Long-Term Effects;longitudinal design;men;Mental Depression;Mental Health;Messenger RNA;middle age;Modeling;Molecular Abnormality;Molecular Genetics;Mothers;Mutate;mutation carrier;Neurodegenerative Disorders;Outcome;Parents;Phenotype;Physiological;premature;Premature Menopause;Prevention;Public Health;respiratory;Risk;Risk Factors;Role;Sinus Arrhythmia;social;social communication;social deficits;social skills;Statistical Methods;Stress;stressor;Symptoms;Testing;Time;United States;Woman;Work

PROJECT_TITLE: Aging Symptom Trajectories in Mother Carriers of the FMR1 Premutation


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Transplantation

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE: Overall In the first phase of HuBMAP, we established the Stanford Tissue Mapping Center to map the complexity of cellular architecture and biomolecular profiles of the small bowel and colon ーorgans that play wide-ranging roles in maintaining normal physiologies of metabolism, immunity, and even neural function. We applied the deep expertise of our team to obtain high-quality biospecimens, characterize tissues using cutting-edge omics and multiparametric imaging techniques, and perform integrative analyses to understand the biomolecular profiles in the context of spatial tissue structure. We have scaled these data-generation and analysis pipelines for production-scale interrogation of the intestinal wall. We will continue these efforts to build three-dimensional multi-modal (snRNA, snATAC, CODEX, multiplex FISH) spatial maps that will give the greater scientific community insights into the molecular underpinnings of normal bowel function.

PI_NAMEs: NOLAN, GARRY P;SNYDER, MICHAEL P. (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: 3-Dimensional;absorption;analysis pipeline;Antibodies;Architecture;Area;ATAC-seq;Biological Assay;Biological Sciences;Blood Vessels;Cell Nucleus;cell type;Cells;Chromatin;Chromosome Mapping;Circulation;Collaborations;Collection;Colon;Communities;Complex;Consent;cost;Data;Data Set;data sharing;data submission;Deposition;Detection;Disease;Donor Selection;Educational workshop;Epithelium;Ethnic Origin;Exposure to;Fluorescent in Situ Hybridization;Food;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Transcription;Genome;genome wide association study;Genomics;graduate student;Heterogeneity;Homeostasis;Human;Human BioMolecular Atlas Program;Human body;Image;Imaging Techniques;Immune;Immunity;Immunoassay;indexing;Individual;Ingestion;insight;Intestines;Length;Lymphatic;Maps;Mediating;Metabolism;Molecular;Motility;Mucous Membrane;multimodal data;multimodality;multiparametric imaging;multiple omics;Muscle;Neighborhoods;Neurophysiology - biologic function;North Dakota;Nucleic Acid Regulatory Sequences;Nutritional;Organ;Organ Donor;Organ Transplantation;Phase;Physiology;Play;Population;Postdoctoral Fellow;Preservation Technique;Process;Production;Proteins;Protocols documentation;public repository;Resolution;Resources;Role;Running;Sampling;Science;sex;Signal Transduction;single cell technology;single nucleus RNA-sequencing;Site;Slide;Small Intestines;Small Nuclear RNA;South Dakota;Structure;Submucosa;Technology;Thick;Tissue Banks;tissue mapping;Tissue Preservation;Tissue Sample;Tissue-Specific Gene Expression;Tissues;Training;transcriptome;transcriptome sequencing;transcriptomics;Tribes;Underserved Population;Work;XCL1 gene

PROJECT_TITLE: Comparing transcriptional and protein-based approaches in 3D tissue altasing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(70)-R]


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative  The research supported by this award will develop new computational methods and tools for drug discovery so that novel therapeutics can be discovered more quickly and with less expense. The de- veloped methods will be evaluated prospectively in drug discovery projects of high relevance to human health. The resources developed will be readily accessible through open-access web sites and open-source software.

PI_NAMEs: KOES, DAVID RYAN (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: 3-Dimensional;Acceleration;Actins;Address;antiangiogenesis therapy;Autoimmune Diseases;Award;Binding;Biological Assay;candidate identification;Chemicals;Code;Computer software;computerized tools;Computing Methodologies;deep learning;deep neural network;Development;Diabetic Retinopathy;Disease;Docking;Drug Design;drug discovery;Evaluation;Generations;generative models;Goals;Health;Human;improved;inhibitor;lead candidate;lead optimization;Learning;Libraries;Ligands;Malignant Neoplasms;Methods;Modeling;Molecular;Molecular Structure;Molecular Target;Neural Network Simulation;novel;novel therapeutics;open source;open source tool;Pharmaceutical Preparations;Physiology;Process;Productivity;profilin;Property;prospective;Proteins;Pythons;Research;research clinical testing;Research Support;Resources;Sampling;screening;small molecule;Structure;tool;Training;Update;user-friendly;web app;web site;Work

PROJECT_TITLE: New Methods and Tools for Computational Drug Discovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Rural Health;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Narrative A pressing societal need is to ensure that the vast number of aging adults can maintain their independence and a good quality of life. Successful use of technology systems is critical to everyday functioning. Thus, examining issues surrounding aging and technology is important to the well-being and independence of older adults.

PI_NAMEs: CZAJA, SARA J (contact)

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: Achievement;Address;Adult;Age;age related changes;Age-associated memory impairment;Aging;aging and technology;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Artificial Intelligence;Awareness;Businesses;Cellular Phone;Chronic;Clinical;Cognition;Cognitive;cognitive enhancement;cohort;Communities;community advisory board;Data;design;Development;Education;Emerging Technologies;Emotional;Enhancement Technology;ethnic diversity;ethnic minority;Ethnic Origin;evidence base;faculty support;Family;Florida;Fostering;Goals;Health;health care disparity;health management;Health Services Accessibility;Healthcare;Heterogeneity;human old age (65+);Illinois;Impaired cognition;improved;Industry;industry partner;innovation;Institution;Internet;Intervention;Learning;Literature;Location;Loneliness;low socioeconomic status;Marketing;Medicine;meetings;Mentors;mild cognitive impairment;minority disparity;Mission;multidisciplinary;older adult;Personal Satisfaction;physical conditioning;Play;Policies;Population;Population Heterogeneity;prevent;Productivity;programs;Protocols documentation;Quality of life;racial diversity;Research;Research Personnel;Resources;response;Risk Factors;Rural;rural area;Safety;Sampling;Scientist;sex;Shapes;Site;social engagement;Social isolation;Solid;Strategic vision;Students;Subgroup;System;Target Populations;Technical Expertise;Techniques;Technology;technology platform;tool;Training;trend;United States National Institutes of Health;uptake;usability;Vision

PROJECT_TITLE: Center for Research and Education on Aging and Technology Enhancement - CREATE


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The implementation science is a field developed in the U.S. and only recently has started to recognize the importance of explicitly recognizing equity in the implementation process. This is a methods-focused study aiming to adapt an evidence-based matrix mentoring model and to center equity in implementation mapping through reflexivity practices. The methods used in this study will serve as a model for other implementation science studies.

PI_NAMEs: HUNLETH, JEAN MARIE (contact);SILVER, MICHELLE

PROGRAM_OFFICER_NAME: ALARO, JAMES R

PROJECT_TERMS: Address;Administrative Supplement;Age;Award;Awareness;career;cervical cancer prevention;Clinic;Collaborations;Color;Colorectal Cancer;colorectal cancer prevention;Community Actions;Country;Development;disparity reduction;Equitable healthcare;Equity;evidence base;Exposure to;Failure;girls;Goals;Health Services;HIV;HIV-infected adolescents;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papillomavirus;implementation process;implementation science;implementation strategy;Income;Infrastructure;Intervention Studies;Investments;Knowledge;Lead;Leadership;low and middle-income countries;Malignant neoplasm of cervix uteri;Maps;Medical;meetings;Mentors;Methodology;Methods;Modeling;Oncology;Outcome;parent grant;Politics;prevent;Process;Public Policy;Publishing;Recommendation;Research;Risk;Science;Scientist;Screening for cancer;Site;skills;social;Structure;supportive environment;tool;Trust;vaccine acceptance;Zambia

PROJECT_TITLE: Leveraging HIV infrastructure to implement cervical cancer prevention: A study to integrate HPV vaccination in adolescent HIV clinics in Zambia


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PI_NAMEs: CURTIS, KATHERINE J. (contact)

PROGRAM_OFFICER_NAME: CLARK, REBECCA L

PROJECT_TERMS: Advocate;Agreement;Area;Award;Budgets;Communication;Cost Sharing;Data;Database Management Systems;Demography;Development;Ecology;Educational workshop;Ensure;Event;Expenditure;experience;Faculty;Financial Support;Funding;Funding Agency;graduate student;Grant;Group Meetings;Human;Human Resources;human subject protection;improved;Individual;Infrastructure;Institution;Institutional Review Boards;meetings;Mission;Monitor;Newsletter;Occupational activity of managing finances;Office of Administrative Management;Organization and Administration;Periodicals;Play;Policies;Population Dynamics;Population Process;Population Research;Population Sciences;Positioning Attribute;Preparation;Productivity;programs;Publications;PubMed;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;Role;Scientific Advances and Accomplishments;Series;Services;social media;Source;Special Event;Students;symposium;Training;Training Activity;Training and Infrastructure;training opportunity;Training Programs;Travel;Twitter;United States National Institutes of Health;Visit;web site;Work;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Clinical Research;Social Determinants of Health

PI_NAMEs: CARLSON, MARCIA JEANNE (contact)

PROJECT_TERMS: Academy;analytical method;Applications Grants;Area;Award;career;Collaborations;Communities;cost;Cost Sharing;data visualization;Demography;design;Development;doctoral student;Ecology;Educational workshop;Equity;Evaluation;Event;Extramural Activities;Faculty;Financial Support;Focus Groups;Fostering;Funding;Funding Opportunities;Goals;Grant;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;Investments;Knowledge;Mentors;Mentorship;Methodology;Monitor;Population;Population Dynamics;population health;Population Research;Population Sciences;Postdoctoral Fellow;Poverty;Preparation;programs;recruit;reproductive;Research;research and development;Research Institute;Research Personnel;Research Project Grants;Research Proposals;Research Support;research vision;Resources;Rotation;Scientist;Secure;Series;skill acquisition;skills;social genomics;symposium;Training;Translations;Universities;Work;working group;Writing

PROJECT_TITLE: Development Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: GRODSKY, ERIC  (contact)

PROJECT_TERMS: analytical tool;Applications Grants;Area;Attention;Authorization documentation;career;Communities;computational platform;Computer software;computerized data processing;computing resources;Consultations;cost;Cost Sharing;Data;Data Analyses;data management;Data Protection;data resource;data tools;Decision Making;Demography;Discipline;Ecology;Educational workshop;Ensure;Equipment;Faculty;frontier;Funding;human capital;Human Subject Research;Influentials;Information Services;Information Technology;Infrastructure;innovation;Institutional Review Boards;knowledge base;Leadership;Learning;Legal;lens;Licensing;Linux;Location;Maintenance;Manuscripts;Mission;National Institute of Child Health and Human Development;notch protein;operation;Peer Review;Population;Population Research;Population Sciences;Productivity;Research;Research Personnel;Resources;Secure;Service provision;Services;Shapes;social science research;Social Sciences;Students;success;Technology;Training;Universities;University resources;Work

PROJECT_TITLE: Scientific and Technical Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project narrative The proposed work is relevant to public health because the discovery of molecular mechanisms of Rhes- mediated tunneling nanotube–like cell-cell communication in cell and animal models is ultimately expected to increase understanding of mechanisms of aging and neurological disorders and provide the framework for developing novel therapeutic strategies based on novel mechanisms-based approaches. Thus, the proposed research is relevant to NIH’s mission that pertains to acquiring fundamental insights that will aid in lessening the pain of humans of disability.

PI_NAMEs: SUBRAMANIAM, SRINI  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Actins;Address;Aging;aging mechanism;Animal Diseases;Animal Model;Animals;Area;Autophagocytosis;Behavior;Binding;Brain;Cell Communication;Cell model;cell type;Cells;Corpus striatum structure;Cultured Cells;Data;disability;Disease;disease model;Disease Progression;Distant;DRD2 gene;drug discovery;Etiology;expression vector;farnesylation;Funding;Genetic Diseases;Glutamine;Homologous Gene;Human;Huntington Disease;Huntington gene;In Vitro;in vivo;inhibition of autophagy;inhibitor;insight;Knowledge;Link;live cell imaging;Mass Spectrum Analysis;Mediating;Membrane;Mission;Modification;Molecular;Mus;mutant;Nanotubes;Nervous System Disorder;Neuroglia;Neurons;neuropathology;novel;novel therapeutic intervention;Pain;parent project;Pathogenesis;Pathway interactions;Peripheral;pharmacologic;Phenotype;Post-Translational Protein Processing;prevent;Process;Proteins;Public Health;Reporter;Research;Role;Route;Signal Transduction;Slice;Specificity;SUMO1 gene;Sumoylation Pathway;Testing;Tissues;Toxic effect;Transgenic Animals;transmission process;Transportation;Ubiquitin;United States National Institutes of Health;Viral Vector;Work

PROJECT_TITLE: Rhes-SUMO Pathway in Huntington disease