ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Heart failure is a major health epidemic in the developed countries, however, the underlying mechanism for this disorder is not well characterized. Tristetraprolin (TTP) is a protein that binds to its target mRNA molecules and causes their degradation, and through this mechanism regulates various cellular processes. In this proposal, we will study the role of TTP in cardiac fatty acid and branched- chain amino acid metabolism, will identify the mechanism for this regulation, and will study the role of TTP in the development of heart failure.

PI_NAMEs: ARDEHALI, HOSSEIN  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: 3' Untranslated Regions;Acids;Address;amino acid metabolism;Animal Model;aorta constriction;Binding;Binding Proteins;branched chain alpha ketoacid dehydrogenase;branched chain fatty acid;Branched-Chain Amino Acids;Cardiac;Cardiac Myocytes;Catabolism;Cell Physiology;Clinical;clinically relevant;Co-Immunoprecipitations;Collaborations;Complex;Data;Defect;Developed Countries;Development;Disease;drug discovery;Elements;Epidemic;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Genes;Genetic study;Health;Heart;Heart failure;heart function;heart metabolism;heart preservation;Homeostasis;Human;human induced pluripotent stem cells;Impairment;improved;Inflammation;Inflammatory;Insulin;Ischemia;Keto Acids;knock-down;Knock-out;Knockout Mice;Knowledge;Link;lipid metabolism;Lipids;Measures;Mediating;Messenger RNA;Metabolic syndrome;Metabolism;Modeling;mRNA Transcript Degradation;Mus;new therapeutic target;novel;oxidation;Oxidoreductase;Pathology;Pathway interactions;Perfusion;Pharmaceutical Preparations;posttranscriptional;PPAR alpha;preservation;pressure;Process;Protein phosphatase;Proteins;Regulation;response;RNA;Role;side effect;Stress;System;systemic inflammatory response;Testing;TIS11 protein;Tissues;TNF gene;uptake;Zinc Fingers

PROJECT_TITLE: Role of mRNA-binding protein tristetraprolin in cardiac mRNA regulation and the development of heart failure


ADMINISTERING_IC: AR

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Human Genome;Pediatric;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Patients affected by Kabuki Syndrome (KS) present with complex phenotypes, which include severe muscular hypotonia and reduced muscle strength. Using conditional and constitutive mouse models, the proposed work will study the primary defects in skeletal muscle following loss of function in KMT2D and KDM6A, the two genes mutated in human KS. The proposed studies will fill major gaps in our lack of knowledge about etiology of hypotonia in Kabuki syndrome and will pave the way for improvements in patient care.

PI_NAMEs: GUSSONI, EMANUELA  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Address;Adult;Affect;ATAC-seq;Automobile Driving;Cardiac;Cells;Clinical;Complex;Data;Defect;Development;Developmental Delay Disorders;Embryonic Development;Enhancers;Epigenetic Process;epigenomics;Etiology;Exhibits;experimental study;EZH2 gene;Fiber;Functional disorder;Gene Expression;gene network;Gene Targeting;Genes;Genetic Transcription;Goals;hearing impairment;Heterogeneity;Heterozygote;Histones;Human;Impairment;improved;Individual;Intellectual functioning disability;Kabuki Make-Up Syndrome;Kidney;Knowledge;Life;Link;loss of function;Methyltransferase;Modeling;Molecular Target;mouse model;Mus;Muscle;Muscle Fatigue;Muscle Fibers;muscle form;Muscle function;Muscle hypotonia;muscle progenitor cell;Muscle satellite cell;Muscular Atrophy;Mutant Strains Mice;Mutate;Mutation;Myosin ATPase;Neural Conduction;Organ;Pathogenicity;Patient Care;Patients;Phenotype;postnatal;promoter;protein complex;Proteins;Rare Diseases;reduced muscle strength;Repression;Role;Secondary to;Severities;Signal Transduction;Skeletal Muscle;Specific qualifier value;stem cell differentiation;stem cell self renewal;Symptoms;System;Tissues;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: Epigenetic dysregulation of muscle differentiation in Kabuki syndrome

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative In this project, we will determine whether plasma transfer approaches can reverse age-related epigenomic changes in microglia and identify genomic sites that could be targeted for mechanistic functional studies. We will also use single-cell molecular phenotypes, cell-specific translatomes, and microglia functional assays to characterize the dynamics of microglia populations in obesity and provide insights into aging- and obesity- associated neuroinflammation. Our long-term goal is to contribute mechanistic insights and knowledge into microglia aging and neuroinflammation and to develop novel strategies to promote healthy brain aging.

PI_NAMEs: ANSERE, VICTOR AFRIYIE (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Address;Affect;Affinity Chromatography;Age;age group;age related;age related changes;Aging;aging brain;Animals;anti aging;Applied Skills;Bioinformatics;Biological Assay;Biology;bisulfite sequencing;Blood Volume;BODIPY;Brain;Caloric Restriction;career;Cell Nucleus;cell type;Cells;chemokine;Communication;cytokine;Data;design;Development;diet-induced obesity;dietary;Disease;DNA;DNA Methylation;DNA Modification Process;Elements;Enhancers;Epigenetic age;epigenetic aging;epigenetic clock;Epigenetic Process;epigenome;epigenome editing;epigenomics;experience;Fatty acid glycerol esters;Fluorescence-Activated Cell Sorting;Foundations;functional decline;Functional disorder;Future;Gene Expression;Genes;Genomics;Goals;Grant;Heterogeneity;High Fat Diet;Hippocampus;immune activation;Impairment;improved;Inflammation;Inflammatory;innovation;insight;interest;Intervention;Knowledge;Laboratories;laboratory experience;late life;Lipids;Macrophage;Maintenance;Manuscripts;Mentors;Messenger RNA;Methylation;Microglia;Modeling;Molecular;molecular phenotype;Morphology;mouse model;Mus;Neurodegenerative Disorders;neuroinflammation;novel strategies;Nuclear;Nutritional;Obese Mice;Obesity;old mice;Operative Surgical Procedures;Oral;Pathologic;Pattern;Phagocytes;Phase;Phenotype;Physiological;Plasma;Population;prevent;Rejuvenation;Research;response;Ribosomes;RNA;Role;Saline;Scientist;sex;single-cell RNA sequencing;Site;skills;Sorting;Structure;systemic inflammatory response;Technical Expertise;Techniques;Technology;Testing;Thinness;Tissues;Training;transcriptome sequencing;transcriptomics;Translating;translational study;translatome;uptake;whole genome;Writing

PROJECT_TITLE: Reversing age-related epigenetic changes and characterizing microglia heterogeneity in obesity and aging


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PHR: Project Narrative Cancer is the result of individual cells escaping tumor suppressive barriers during the lifetime of an organism. Understanding these escape mechanisms and enhancing tumor suppressive barriers is of utmost importance in our efforts in treating cancer and preventing the early steps of tumor formation. This proposal focuses on the mechanisms that are in place to eliminate cells during replicative crisis, suggesting that autophagy upregulation is an essential step in activating this final barrier against cancer cell development.

PI_NAMEs: KARLSEDER, JAN  (contact);SHAW, REUBEN

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Apoptosis;Apoptotic;Applications Grants;Autophagocytosis;Bypass;cancer cell;candidate identification;Cell Aging;Cell Cycle Checkpoint;Cell Death;Cell Nucleus;Cell Proliferation;Cells;Cytoplasm;Data;design;Development;DNA;DNA Damage;Event;expectation;Functional disorder;Genome;genome integrity;genome-wide;genomic aberrations;Genomic Instability;Genotoxic Stress;Goals;Growth;Human;Impairment;in vivo;Individual;inhibition of autophagy;inhibitor;Lead;Learning;loss of function;Malignant - descriptor;Malignant Neoplasms;Mitochondria;Molecular;mouse model;Nature;neoplastic;neoplastic cell;novel;Organelles;Organism;Pathway interactions;peroxisome;Phase;Population;Premalignant Cell;prevent;Process;Proliferating;Proteins;Resistance;response;Ribosomes;Role;senescence;Signal Pathway;Signal Transduction;Site;Stimulator of Interferon Genes;Stress;telomere;Telomere Maintenance;Testing;Time;tool;TP53 gene;tumor;Tumor Escape;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis;Up-Regulation

PROJECT_TITLE: Understanding the role of autophagy-regulated cell death in the escape from replicative crisis

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE  Clonal hematopoiesis of indeterminate potential (CHIP) is an occult pre-cancerous proliferation of cells in the blood that leads to an increase in cardiovascular disease and overall mortality. The association between CHIP and sudden cardiac death (SCD) and the mechanism by which CHIP might contribute to SCD remain unknown. We propose targeted sequencing for CHIP in blood and heart samples from our unique cohort of autopsy-confirmed SCDs, and quantitative histologic and molecular phenotyping of heart tissue to determine how CHIP contributes to vulnerable substrate for lethal arrhythmias underlying SCD.

PI_NAMEs: TSENG, ZIAN H (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Age;Arrhythmia;atrioventricular node;Autopsy;Belief;Biological;Blood;Blood specimen;Blood Vessels;Cardiac;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;Case/Control Studies;Cause of Death;Cell Proliferation;cell type;Cells;Cessation of life;Clinical;cohort;Communities;comparison control;Coronary Arteriosclerosis;coronary fibrosis;County;Coupling;Data;Diagnosis;diagnostic criteria;DNMT3a;Event;exome sequencing;Fibrosis;Frequencies;Fright;Funding;Gene Expression;Gene Expression Profile;Gene Frequency;General Population;Genes;Genetic Transcription;genetic variant;Health;Heart;Heart Diseases;Hematologic Neoplasms;Hematopoiesis;Histologic;Homeostasis;Hypertrophy;Immune;immune cell infiltrate;Individual;Infiltration;Inflammation;Inflammatory;innovation;insight;interstitial;Ischemic Stroke;Knowledge;Leukocytes;Link;Macrophage;Macrophage Activation;Modeling;molecular phenotype;mortality;mutant;Mutation;Myocardial;Myocardium;National Heart, Lung, and Blood Institute;Outcome;peripheral blood;Phenotype;Population;Preleukemia;premalignant;Process;prospective;Reporting;Research;Resolution;Rest;Risk;Risk Factors;risk stratification;RNA;Role;Sampling;sudden cardiac death;Sudden Death;System;targeted sequencing;Testing;Therapeutic;Time;Tissues;Trauma;vascular inflammation

PROJECT_TITLE: Clonal Hematopoeisis of Indeterminate Potential and Risk of Autopsy-defined Sudden Cardiac Death

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: BINGHAMTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

ORG_STATE: NY

PHR: PROJECT NARRATIVE: Parkinson’s disease is most effectively treated with the drug L-DOPA. Unfortunately, over time, L-DOPA produces debilitating side effects called dyskinesia that occur in up to 90% of patients within a decade. Studies herein employ human post-mortem tissue and a preclinical model of Parkinson’s disease to investigate aberrant neuroplasticity that emerges when dyskinesia occurs. We will show that correcting these maladaptations reduces L-DOPA side effects but not its benefits, thereby identifying new ways to improve Parkinson’s disease treatment.

PI_NAMEs: BISHOP, CHRISTOPHER R (contact);MANFREDSSON, FREDRIC ;TSENG, KUEI-YUAN

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: abnormal involuntary movement;Anatomy;Animal Disease Models;Automobile Driving;Autopsy;Autoreceptors;Basic Science;Behavior;Behavioral;Brain;Brain Diseases;Cells;Clinical;Clinical Sciences;Corpus striatum structure;cost;Data;Denervation;designer receptors exclusively activated by designer drugs;Development;Dopamine;dopamine replacement therapy;Dyskinetic syndrome;Electrophysiology (science);Experimental Parkinsonism;Fiber;gain of function;Genetic;genetic approach;Goals;Homeostasis;Human;Hyperactivity;improved;in vivo;innovation;insight;interest;Intervention;Investigation;Knowledge;L-DOPA induced dyskinesia;Levodopa;Link;Mediating;Methods;Microdialysis;Microscopy;Midbrain structure;Minority;neurochemistry;Neuronal Plasticity;Neurons;Neurosciences;neurotransmission;neurotransmitter release;Neurotransmitters;novel;novel strategies;optimal treatments;Output;Parkinson Disease;Parkinsonian Disorders;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Photometry;pre-clinical;Pre-Clinical Model;prevent;prospective;Quality of life;Rattus;Research;Research Personnel;Serotonin;side effect;Source;standard care;stem;Synapses;Techniques;Technology;Testing;Time;Tissues;tool;TPH2;treatment strategy

PROJECT_TITLE: Interrogating Maladaptive Serotonin Raphe-Striatal Plasticity in L-DOPA-Induced Dyskinesia

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Endocrine Disruptors;Intellectual and Developmental Disabilities (IDD);Microbiome;Neurosciences;Pediatric

ORG_CITY: IOWA CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The proposed research will demonstrate that dysbiosis of the gut microbiome acts in concert with direct effects of environmental toxicants on the developing brain/liver, and the influence of these interactions on neurodevel- opmental outcomes. This outcome is relevant to public health because it will provide critical insights regarding the plausibility of microbiome-based approaches to diagnose and treat neurodevelopmental disorders induced by exposure to PCBs and, potentially, other developmental neurotoxicants. Therefore, the proposed research is pertinent to the part of NIH's mission that seeks to develop fundamental knowledge about living systems to enhance health and reduce the burden of human disease.

PI_NAMEs: CUI, JULIA YUE ;LEHMLER, HANS-JOACHIM  (contact);LEIN, PAMELA J

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Address;Adolescent;Adult;adverse outcome;Affect;Behavior;Brain;Cytochromes;Data;Development;developmental neurotoxicity;Diagnosis;Diet;Dose;dysbiosis;Environment;Enzymes;Etiology;Evaluation;experimental study;Exposure to;Family;fecal transplantation;Fetus;Future;Germ-Free;Goals;gut dysbiosis;gut microbiome;Health;Hepatic;human disease;Individual;innovation;insight;Intervention;Knowledge;Lactation;Life;Link;Liver;Maternal Exposure;Measures;Mediating;Metabolic Biotransformation;Metabolism;Microbe;microbial;microbiome;microbiome alteration;microbiome composition;Mission;mother nutrition;mouse development;mouse model;multidisciplinary;Mus;Neonatal;neurodevelopment;Neurodevelopmental Disorder;neuroinflammation;neurotoxic;neurotoxicity;Neurotoxins;novel;Organism;Outcome;Outcome Study;Oxidative Stress;Polychlorinated Biphenyls;Positioning Attribute;Predisposition;Pregnancy;Public Health;pup;Research;Rodent;Role;Societies;Synapses;Systems Biology;Testing;Toxic Environmental Substances;Transplantation;United States National Institutes of Health

PROJECT_TITLE: PCB-mediated dysbiosis of the gut microbiome: A missing link in PCB-mediated neurodevelopmental disorders?

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The management of cardiovascular and metabolic health, including type 2 diabetes mellitus (T2DM), is an important part of healthy aging and affects risk of Alzheimer's disease and related dementias (ADRD). The proposed research aims to examine how patient cost burden, as measured in uninsured individuals and high deductible health plan (HDHP) enrollees, affects the management and progression of T2DM, potentially leading to long-term consequences for the incidence and burden of ADRD. This will be accomplished with an innovative simulation model, that connects existing models of T2DM progression and aging, to build understanding of the complicated interplay between health policies, healthy aging, and ADRD.

PI_NAMEs: BARTHOLD, DOUGLAS  (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Adherence;Affect;Aging;aging population;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Award;Biological;Biological Markers;burden of chronic illness;Cardiovascular Diseases;Cardiovascular system;career;Caregivers;Caring;Centers for Disease Control and Prevention (U.S.);Chronic;Chronic Disease;Clinical;comparative;comparative effectiveness;cost;Deductibles;dementia risk;design;Development;diabetes management;Diabetes Mellitus;Disease;economic outcome;Elderly;Ensure;Epidemiology;Event;Expenditure;experience;Face;Future;Geriatrics;Goals;Health;health care availability;health care model;health economics;health plan;Health Policy;Health Services Accessibility;Health system;Healthcare;healthcare burden;healthy aging;high risk;Hyperlipidemia;Hypertension;Incidence;Individual;innovation;Insurance;Intervention;Knowledge;Lead;Leadership;Link;Long-Term Care;Long-Term Effects;Measures;Medical;medication compliance;Mentorship;Metabolic;Metabolic Diseases;Methods;Modeling;models and simulation;Modernization;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Patient Outcomes Assessments;Patients;Penetration;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacologic Substance;Policies;Policy Making;Population;Population Dynamics;Positioning Attribute;Prediction of Response to Therapy;Prevalence;prevent;Prevention;programs;Reporting;Research;Research Methodology;Research Personnel;Resources;Review Literature;Risk Factors;Role;simulation;skill acquisition;social;success;Time;Training;Translating;Uninsured;Validation;Variant;Work

PROJECT_TITLE: Long-term effects of today's medical care access policies on the future burden of Alzheimer's disease and related dementias

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Transgender youth in the United States have unique health needs but often face barriers to accessing and receiving health care services which contribute to disparate health outcomes, including high vulnerability to HIV and other sexually transmitted infections. The proposed MyPEEPS intervention for young transgender men is a novel and evidence-driven intervention using mobile technology to deliver HIV prevention information to high- risk youth. The final product will be the basis for conducting a large-scale efficacy study in this population.

PI_NAMEs: GAROFALO, ROBERT ;SCHNALL, REBECCA  (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: 18 year old;19 year old;Address;Adolescent and Young Adult;AIDS prevention;Behavior;Behavior Therapy;Behavioral;Birth;Caricatures;cis-male;cisgender;Clinical;Cohort Studies;condomless anal sex;Data;Development;efficacy study;efficacy trial;Eligibility Determination;Enabling Factors;Epidemiology;experience;Face;Family;feasibility testing;Feedback;Female;Focus Groups;Future;Gender Identity;Goals;Health;health care service;health outcome disparity;High Prevalence;high risk;high risk behavior;HIV;HIV Infections;Human immunodeficiency virus test;improved;Individual;interest;Intervention;Interview;Literature;male;Mechanics;Methodology;Methods;mHealth;minority children;mobile application;mobile computing;multidisciplinary;New York City;novel;peer;Population;pre-exposure prophylaxis;Predisposing Factor;Prevalence;Prevention;Prevention program;preventive intervention;Principal Investigator;Public Health;Randomized, Controlled Trials;Reinforcing Factor;Reporting;Research;response;Risk;Risk Behaviors;Sampling;scale up;Science;sex;sex assigned;sexual debut;Sexual Health;sexual minority;sexual minority men;Sexually Transmitted Diseases;Site;social;Testing;therapy design;Time;transgender;transgender men;transgender women;United States;uptake;usability;Work;young men who have sex with men;Youth

PROJECT_TITLE: Development and Testing of MyPEEPS Mobile for Young Transgender Men

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Palliative Care;Radiation Oncology;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Liver cancer derives its blood supply mainly from the hepatic artery. Interventional radiologic intra-arterial therapies exploit the unique property to deliver targeted therapies to liver cancer, while surrounding liver tissues remain largely unaffected. The goal of this research is to develop and optimize highly potent intra-arterial alpha- emitting radiopharmaceutical therapy for targeted treatment of liver cancer.

PI_NAMEs: NEDROW, JESSIE  (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: 90Y;Address;advanced disease;Algorithms;Alpha Particle Emitter;Alpha Particles;Animals;anti-PSMA;Arterial Embolization;Biodistribution;Calcium;cancer diagnosis;Cancer Etiology;cancer imaging;Cancer Patient;Castration;cell killing;Cells;Cessation of life;Chemoembolization;chemotherapy;Clinic;clinically relevant;Companions;Compensation;Complex;Contrast Media;cytotoxicity;Data;Daughter;Development;Disseminated Malignant Neoplasm;Distributional Activity;DNA Damage;Dose;dosimetry;Doxorubicin;Drug Kinetics;Drug Monitoring;Emulsions;Energy Transfer;Evaluation;experience;FDA approved;Formulation;Glass;Goals;Hep3B;Hepatic artery;HepG2;Human;Image;image guided;imaging agent;improved;Injections;Interventional radiology;Linear Energy Transfer;Liver;liver cancer model;Liver neoplasms;Malignant neoplasm of liver;Malignant neoplasm of prostate;Metastatic Neoplasm to the Bone;Metastatic Neoplasm to the Liver;Metastatic Prostate Cancer;Methods;Microspheres;mimetics;Modeling;molecular imaging;mouse model;Mus;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Organ;Oryctolagus cuniculus;Palliative Care;particle therapy;Pathway interactions;Patients;Pharmacology;Portal vein structure;preclinical evaluation;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Property;Protocols documentation;Radio-Opaque;Radioembolization;Radiofrequency Interstitial Ablation;Radioisotopes;Radiopharmaceuticals;Recommendation;reconstruction;Regimen;Research;Resistance;resistance mechanism;response;Roentgen Rays;Route;single photon emission computed tomography;Site;small molecule;Source;standard of care;success;systemic toxicity;targeted treatment;Testing;theranostics;Therapeutic;Therapeutic Agents;therapy outcome;Time;Tissues;Toxic effect;Translating;treatment effect;Treatment Efficacy;tumor;tumor growth;tumor vascular supply;Tumor-Derived;Unresectable;Vascular blood supply;Visualization;Work;X-Ray Computed Tomography;Xenograft Model

PROJECT_TITLE: Alpha-Particle Emitter Radiopharmaceutical Therapy for Liver Cancer

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Prevention;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

PHR: Project Narrative The proposed research will determine the underlying mechanism(s) for increased cancer risk in individuals with the African-centric p53 hypomorph P47S. This hypomorph exists in over 800,000 African-descent individuals in the United States, and accomplishing these aims has important implications for understanding cancer risk in under-represented populations, and for informing personalized medicine approaches.

PI_NAMEs: MURPHY, MAUREEN E. (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Adopted;African;African American population;African ancestry;Alleles;Antioxidants;Apoptosis;biobank;Bioinformatics;Biological Assay;Biology;Bladder Neoplasm;Cancer Burden;cancer health disparity;cancer risk;cancer therapy;CD8-Positive T-Lymphocytes;Cells;chemotherapy;Chromatin Remodeling Factor;Cisplatin;Combined Modality Therapy;Cysteine;Cystine;Data;Data Analyses;Defect;efficacy testing;Ethnic Population;Funding;Genes;Genetic;Genetic Transcription;Genetic Variation;genotoxicity;Glutathione;Goals;Health;Human;human data;Immune;Immune checkpoint inhibitor;Impairment;Implant;improved;Incidence;Individual;individualized medicine;inhibitor;insight;Iron;Iron Overload;Laboratories;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Medicine;Minority;Modeling;Molecular Conformation;mouse model;Mus;mutant;Mutation;Myeloid-derived suppressor cells;neoplastic cell;NF-kappa B;NFKB Activation Pathway;novel;Open Reading Frames;Outcome;Performance;personalized medicine;Pharmaceutical Preparations;Play;Population;protein function;Proteomics;Protocols documentation;Publishing;Request for Applications;Research;Resistance;Risk Factors;Role;senescence;success;Testing;Therapeutic;Tissues;TP53 gene;Transactivation;tumor;tumor microenvironment;Tumor Suppression;Tumor Suppressor Proteins;Underrepresented Populations;United States;Variant;Xenograft procedure

PROJECT_TITLE: Functional Analysis of p53 Polymorphic Variants

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Autoimmune Disease;Biomedical Imaging;Cardiovascular;Clinical Research;Diabetes;Heart Disease;Heart Disease - Coronary Heart Disease;Kidney Disease;Pediatric;Prevention

ORG_NAME: JOSLIN DIABETES CENTER

PHR: NARRATIVE The proposed study will investigate the etiologic links between DKD and diabetic cardiomyopathy in type 1 diabetes and, in particular, the novel hypothesis that myocardial remodeling is observed early in the process of progressive kidney function decline, before substantial GFR loss has occurred. The results of this study will be crucial for the development of innovative strategies, and possibly new drugs, to prevent the critical problem of CVD in T1D patients with DKD.

PI_NAMEs: DORIA, ALESSANDRO  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Acceleration;Address;Age;Albuminuria;Atherosclerosis;Biological Markers;Blood Glucose;Blood Pressure;Calcium;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cholesterol;Cicatrix;Clinic;Coronary Arteriosclerosis;coronary artery calcium;Data;Development;Diabetes Mellitus;diabetic;diabetic cardiomyopathy;Diabetic Nephropathy;Disease;Disease Pathway;Early identification;End stage renal failure;Etiology;Event;experience;extracellular;Fiber;Fibrosis;Fostering;functional decline;Functional disorder;Gadolinium;Goals;Hand;Health;Heart Atrium;Heart failure;heart function;heart imaging;high risk;Hypertrophy;Impairment;improved;indexing;Individual;innovation;insight;Insulin-Dependent Diabetes Mellitus;interstitial;Intervention;Ischemia;Left Ventricular Ejection Fraction;Left Ventricular Mass;Link;Magnetic Resonance;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Morbidity - disease rate;mortality;multiplex assay;Myocardial;Myocardium;Nature;non-diabetic;novel;novel strategies;novel therapeutics;Participant;Patients;Persons;Play;Population;Positioning Attribute;preservation;prevent;Process;Recording of previous events;Renal function;response;Risk;Risk Factors;Role;Serum Proteins;Severities;Smoking;Sudden Death;Systole;tool;Tumor Necrosis Factor Receptor;Ventricular Remodeling;X-Ray Computed Tomography

PROJECT_TITLE: Early myocardial remodeling and progressive kidney function decline in type 1 diabetes


NIH_SPENDING_CATS: Cancer;Orphan Drug;Rare Diseases;Skin Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: DERMATOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE SOX2 is as an essential driver of squamous carcinogenesis in mice and patients, but how its activity is regulated in these tumors remains unknown. We discovered that SOX2 can be phosphorylated in squamous cell carcinomas, and we propose to a) determine how SOX2 phosphorylation influences its activity, b) identify the kinases and phosphatases that regulate its function, and c) define the mechanisms by which SOX2 phosphorylation governs squamous carcinogenesis in mouse and patient-derived squamous cell carcinoma models. Once the function and regulation of SOX2 phosphorylation have been determined, we can begin to develop novel therapies that activate the kinases or inhibit the phosphatases to better treat the >20,000 squamous cell carcinoma patients who currently die from their disease in the United States each year.

PI_NAMEs: SCHOBER, MARKUS  (contact)

PROJECT_TERMS: Ablation;Acceleration;Affect;androgen independent prostate cancer;Attenuated;Biological Assay;Cancer Patient;cancer therapy;carcinogenesis;CDK5 gene;Cell Nucleus;Cells;ChIP-seq;Chromatin;Clonal Expansion;Co-Immunoprecipitations;Complex;Cutaneous;Data;Development;Disease;Enhancers;Epithelial Cells;Gene Expression;Genes;Genetic Transcription;Glioblastoma;Growth;Head and Neck Squamous Cell Carcinoma;Human;Immune checkpoint inhibitor;Knock-in Mouse;Ligation;Malignant Epithelial Cell;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant Neoplasms;Measures;mimetics;Modeling;Modification;Molecular;mouse model;Mus;mutant;Mutation;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;organ transplant recipient;Osteosarcoma;patient derived xenograft model;Patients;Pattern;pharmacologic;phosphatase inhibitor;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Inhibition;Phosphotransferases;prevent;programs;Publishing;Recurrence;Regulation;Repression;Research;Resected;self-renewal;single molecule;Skin;skin squamous cell carcinoma;Squamous cell carcinoma;Squamous Cell Lung Carcinoma;Squamous Differentiation;stemness;tandem mass spectrometry;Testing;Therapeutic immunosuppression;transcription factor;tumor;United States;Western Blotting

PROJECT_TITLE: Post-translational SOX2 modification - a regulatory switch between self-renewal and differentiation in squamous cell carcinoma

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because understanding which plausible combinations of current therapeutic strategies may achieve an HIV functional cure using data-validated mathematical models may significantly optimize the design of experiments and clinical trials geared to that purpose. Thus, this proposal is relevant to the part of NIH’s mission that pertains to fostering fundamental creative discoveries and innovative research strategies as a basis for ultimately protecting health.

PI_NAMEs: SCHIFFER, JOSHUA TISDELL (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Acute;Adult;Aftercare;Agreement;antiproliferative agents;antiretroviral therapy;CAR T cell therapy;Caring;CD4 Positive T Lymphocytes;Cell Therapy;Cells;Characteristics;Chronic;Clinic;Clinical Trials;Collaborations;collaboratory;combinatorial;Combined Modality Therapy;Consensus;Consumption;control theory;cost;Creativeness;curative treatments;Data;Dose;Drug Kinetics;effective intervention;Encapsulated;Experimental Designs;experimental study;Fostering;Fred Hutchinson Cancer Research Center;Gene Modified;gene therapy;gene transplantation for gene therapy;Genetic Variation;Goals;Health protection;HIV;HIV anti-retroviral;HIV Infections;HIV therapy;Home;Human;Immunologics;in silico;in vivo;Individual;Infrastructure;Infusion procedures;Ingestion;innovation;Interruption;Intervention;Kinetics;life span;Link;Lymphocyte;mathematical model;Military Personnel;Mission;Modeling;multimodality;nanoparticle;nonhuman primate;Outcome;Outcome Measure;Pattern;Peptide antibodies;Persons;pill;prevent;Probability;process optimization;programs;Public Health;Research;Research Personnel;response;Running;Safety;Schedule;simulation;Site;social stigma;stem cells;synthetic antibodies;Testing;theories;Therapeutic;Time;Training;translational therapeutics;transmission process;treatment duration;Treatment Efficacy;United States National Institutes of Health;Vaccination;Vaccine Therapy;Viral;viral rebound;Virus Replication

PROJECT_TITLE: Mathematical modeling of optimal therapeutic combinations for HIV cure

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases;Tuberculosis;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

ORG_CITY: Durban

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: CENTRE/AIDS PROGRAMME/RES/SOUTH AFRICA

PHR: In the global HIV epidemic, Africa accounts for about 70% of the 38 million people living with HIV (PLHIV) and the 1.7 million new infections. In South Africa, which has a fifth of all the PLHIV in the world, the province of KwaZulu-Natal bears a disproportionate burden, with 2 million PLHIV. In this province, community-based adult HIV prevalence exceeds 30% and incidence rates exceed 4 per 100 person-years. KwaZulu-Natal also has a substantial tuberculosis burden, with 50,822 new cases of tuberculosis (incidence of 494 per 100,000) in 2018, of which about 60% are co-infected with HIV. The KwaZulu-Natal Clinical Trials Unit’s overall goal is to contribute to the scientific priorities of the four Clinical Trial Networks through novel research concepts, innovative prevention technologies and high-quality clinical trials in target populations by highly experienced research teams at well-equipped Clinical Research Sites.

PI_NAMEs: ABDOOL KARIM, QUARRAISHA  (contact)

PROGRAM_OFFICER_NAME: CASTILLO, BLANCA E

PROJECT_TERMS: Accreditation;Acquired Immunodeficiency Syndrome;Adolescent;Adult;Africa;AIDS prevention;Antibodies;Breast Feeding;Cessation of life;Child;Childhood;Clinical;clinical research site;clinical trial implementation;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;cohort;Communication;Communication Tools;Communities;community advisory board;community engagement;Conduct Clinical Trials;Country;Data;data management;Data Management Resources;Decision Making;Development;Enrollment;Ensure;Epidemic;Evaluation;experience;Fostering;Funding;Generations;Goals;Good Clinical Practice;Health;Health Services;high risk population;HIV;HIV prevention trial;HIV vaccine;HIV Vaccine Trials Network;HIV/TB;Incidence;Individual;Infection;Influentials;Injectable;innovation;International Maternal Pediatric Adolescent AIDS Clinical Trials;Journals;Laboratories;Laboratory Technicians;Leadership;Medical Research;Medicine;meetings;Monitor;mortality;mosaic;neutralizing antibody;Nevirapine;New England;Newsletter;novel;novel strategies;Nurses;Occupational activity of managing finances;Oral;organizational structure;Participant;Persons;Pharmacists;Pharmacy facility;Phase;point of care;Policies;Politics;Population;Population Heterogeneity;pre-exposure prophylaxis;Pregnant Women;Prevalence;Prevention;Prevention strategy;Prevention therapy;programs;Prophylactic treatment;Protocols documentation;Province;Public Health;Publications;quality assurance;Reporting;Research;Research Personnel;Research Priority;Research Support;Resources;retention rate;Role;Safety;Science;Scientist;Seminal;service providers;Site;skills;sound;South Africa;South African;symposium;Target Populations;Technology;Tenofovir;Training;transmission process;Travel;treatment optimization;treatment strategy;treatment trial;Tuberculosis;Tuberculosis Vaccines;United Nations;vaccine immunogenicity;vaccine trial;vaginal microbiome;Viral Load result;Virus;Vision;web site;Work;working group

PROJECT_TITLE: KwaZulu-Natal Clinical Trials Unit


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE  This research is expected to have an important positive impact because if successful, it will provide a new path for rapidly designing high-quality inhibitors of protein kinases; these inhibitors can be used as tools for discovery and as starting points for drug development. This contribution is significant because kinases are among the foremost drug targets for a variety of human diseases, including cancer.

PI_NAMEs: RINK, LORI  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: 3-Dimensional;Address;Affinity;Benchmarking;Binding;Binding Sites;Biochemical;Biological Assay;Cancer Biology;Cells;Cellular Assay;Chemicals;Collection;Color;Communities;comparative;Complement;Complex;Computing Methodologies;convolutional neural network;Couples;deep learning;Descriptor;design;Development;drug development;Drug Targeting;Enzymes;experimental study;Foundations;Gastrointestinal Stromal Tumors;Goals;Human;human disease;improved;Individual;inhibitor;International;kinase inhibitor;Libraries;Malignant Neoplasms;method development;Methods;model building;Modeling;Modernization;neglect;novel;Orphan;Pathway interactions;Pharmaceutical Chemistry;Phenotype;Phosphorylation;Phosphotransferases;predictive modeling;preference;Property;Protein Kinase;protein kinase inhibitor;Proteins;Proteomics;Publishing;Rationalization;recurrent neural network;Research;Research Personnel;Resolution;Route;scaffold;Screening Result;Signal Transduction;skills;small molecule libraries;structural biology;Structural Models;Structure;Testing;Text;Therapeutic;Thinness;three-dimensional modeling;tool;Training;virtual;virtual library;X-Ray Crystallography

PROJECT_TITLE: Designing selective kinase inhibitors via deep learning

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


NIH_SPENDING_CATS: Hematology

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PI_NAMEs: BUEHLER, PAUL WERNER;IRWIN, DAVID CHARLES (contact);PALMER, ANDRE FRANCIS

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TITLE: Aerosolized therapy for hemoglobin toxicity in the treatment of hemolytic diseases

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Electronic Nicotine Delivery Systems;Genetics;Lung;Lung Cancer;Prevention;Rare Diseases;Tobacco;Tobacco Smoke and Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Tobacco products are major causes of lung cancer and oral cavity cancer, which together will kill more than 140,000 people in the U.S. in 2019. The goals of this project are to quantify metabolites and DNA damage originating from specific carcinogens in tobacco products, and use this information to identify people who may be particularly susceptible to their carcinogenic effects so that intensive cancer prevention efforts can be initiated.

PI_NAMEs: HECHT, STEPHEN S (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone;Accounting;adduct;Adult;Age;Amino Acids;analytical method;Animal Model;biobank;Biological Markers;biomarker development;Cancer Burden;Cancer Etiology;cancer prevention;cancer risk;Carcinogen exposure;carcinogenesis;carcinogenicity;Carcinogens;Cause of Death;Cells;Cessation of life;Cigarette;cigarette smoke;Cigarette Smoker;cigarette smoking;Clinical Research;Consumption;Country;Dangerousness;Data;Development;Disease;DNA;DNA Adducts;DNA Binding;DNA biosynthesis;DNA Damage;Electronic cigarette;environmental tobacco smoke exposure;epidemiology study;Esophagus;Evaluation;Exposure to;exposure to cigarette smoke;Female;Genes;genetic information;Goals;Growth;Guanine;heated tobacco products;High-Risk Cancer;Human;International Agency for Research on Cancer;Label;Laboratories;Laboratory Animals;Link;Lung;Lung nodule;male;malignant mouth neoplasm;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Marketing;Mass Spectrum Analysis;men;Metabolic Activation;Metabolism;Methodology;Mutation;N'-nitrosonornicotine;Nitrosamines;Oral;Oral cavity;Persons;Predisposition;Preventive measure;programs;Property;Rattus;Regulation;Research;Resolution;Risk;RNA;Sampling;Site;Smokeless Tobacco;smokeless tobacco user;Smoker;Source;specific biomarkers;Structure of parenchyma of lung;System;Techniques;Testing;Tissues;Tobacco;tobacco control;tobacco exposure;Tobacco Industry;tobacco products;Tobacco smoke;Tobacco use;tobacco user;Tobacco-Associated Carcinogen;Tobacco-Related Carcinoma;Uncertainty;urinary;Urine;Woman;Work

PROJECT_TITLE: Metabolism of Carcinogenic Tobacco-Specific Nitrosamines

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Contraception/Reproduction;Endocrine Disruptors;Estrogen;Heart Disease;Hypertension;Infertility;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Hypertensive disorders of pregnancy such as preeclampsia, eclampsia, and gestational hypertension are increasingly common in the United States and pose potentially serious risks to both mothers and babies, raising the likelihood of adverse birth outcomes and later cardiovascular disease in women. Hypertensive disorders of pregnancy are often linked to abnormal placental function, and recent research suggests that environmental chemicals found in plastics and personal care products may influence factors that affect placental development. This project will be the first to examine how exposure to these ubiquitous environmental chemicals may affect the placenta during pregnancy and women’s own cardiovascular health both before and after pregnancy.

PI_NAMEs: KAHN, LINDA G (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: advanced maternal age;adverse birth outcomes;Affect;Age;Angiogenesis Inhibitors;Angiogenic Factor;apprenticeship;Attention;Award;Biological;Biological Markers;Birth;Birth Weight;bisphenol A;Blood flow;Blood Pressure;blood pressure elevation;Blood Vessels;Body fat;Body mass index;Cardiac Output;Cardiovascular Diagnostic Techniques;Cardiovascular Diseases;cardiovascular effects;cardiovascular health;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;career;Cause of Death;Chemical Exposure;Chemicals;Child;Child Health;Chronic;Clinical;cohort;Complex;Conceptions;cytokine;Data;design;Diabetes Mellitus;Diethylhexyl Phthalate;early pregnancy;Eclampsia;Education;Educational workshop;Endocrine Disruptors;Endothelium;Environment;environmental chemical;Environmental Epidemiology;Epidemiologist;experience;Exposure to;Faculty;Fertility;fetal;Fetal Development;follow-up;Functional disorder;Funding;Goals;Growth;Growth and Development function;Health;Hospitalization;Hypertension;Impairment;Incidence;Inflammatory;Link;Lipids;Long-Term Effects;longitudinal analysis;Maternal and Child Health;Maternal Exposure;maternal serum;Measurable;Measures;Mentorship;Methodology;Mothers;neonatal morbidity;Neonatal Mortality;New York;Nulliparity;Nutrient;Organ;Outcome;Participant;Pathway interactions;Perfusion;personal care products;PGF gene;Phase;phthalates;Physiologic pulse;Placenta;Placentation;Plastics;Population;Positioning Attribute;post pregnancy;post-doctoral training;postnatal;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy disorder;pregnancy hypertension;Pregnancy Trimesters;prenatal;prepregnancy;Principal Investigator;Publishing;Questionnaires;recruit;reproductive;reproductive epidemiology;reproductive success;Research;Research Activity;Research Personnel;Research Project Grants;Risk;Risk Factors;Seminal fluid;Serum;skills;Statistical Methods;time-to-pregnancy;Training;Training Activity;United States;Universities;urinary;Vascular Endothelial Growth Factor Receptor-1;Vascularization;Weight;Woman;Women's Health;Work

PROJECT_TITLE: Nonpersistent chemical exposure, placental development, and maternal pre- and post-pregnancy cardiovascular health

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Microbiome;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: IRVINE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Cancer immunotherapies including checkpoint inhibitors have revolutionized the treatment of multiple cancer types, yet these drugs are only effective in a small subset of patients. Although specific members of the gut microbiota have been positively correlated with patient outcomes, the mechanisms underlying these clinical observations remain largely unknown. Using a combination of chemical tools, biochemical characterization, and in vivo model systems, this proposal will examine enzymatic mobilization of microbial glycans from the gut as a common mechanism to prime host immune responses during checkpoint blockade, with the goal of augmenting the efficacy of current and next-generation checkpoint immunotherapies.

PI_NAMEs: GRIFFIN, MATTHEW EVERETT (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Acetylmuramyl-Alanyl-Isoglutamine;Address;Affinity;Animal Model;anti-microbial peptide;Antibodies;Antigens;antimicrobial;Applications Grants;Bacteria;Biochemical;Biological Models;cancer immunotherapy;Cancer Model;Cancer Patient;cancer therapy;cancer type;career;career development;Caring;CD47 gene;Cell Wall;Cells;checkpoint therapy;Chemicals;chemoproteomics;Chemosensitization;Clinic;Clinical;Clinical Research;Collaborations;Communication;Complement;Data;Development Plans;Disease;Drug Targeting;Eligibility Determination;Endopeptidases;Enterococcus;Environment;Enzymes;experimental study;Foundations;Funding;gastrointestinal epithelium;Genetic;Glycopeptides;Glycoside Hydrolases;Goals;gut microbiota;Health;host-microbe interactions;Human;Hydrolase;Hydrolysis;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immunity;Immunologics;immunoregulation;Immunotherapy;improved;in vivo Model;insight;Intrinsic factor;K22 Award;Knock-out;KPC model;Laboratories;Malignant Neoplasms;Mediating;Melanoma;member;Methods;Microbe;microbial;microbial colonization;microbial host;microorganism;Modeling;Molecular;mouse model;Muramidase;Myelogenous;N-Acetylmuramoyl-L-alanine Amidase;next generation;Non-Small-Cell Lung Carcinoma;oral supplementation;Orthologous Gene;Outcome;pancreatic ductal adenocarcinoma model;patient response;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Peptidoglycan;Phagocytosis;Pharmaceutical Preparations;Phenotype;Polysaccharides;Population;Postdoctoral Fellow;pre-clinical;precision oncology;Probiotics;Production;Proteins;PTPRC gene;rapid test;Reporter;Research;Research Personnel;Residual state;response;Role;Science;Signal Transduction;skill acquisition;skills;small molecule;synergism;T-Cell Activation;targeted treatment;therapy outcome;Tissues;tool;tool development;Training;transgene expression;triple-negative invasive breast carcinoma;tumor;tumor immunology;Work

PROJECT_TITLE: Augmenting cancer checkpoint immunotherapies via microbially-derived metabolites


NIH_SPENDING_CATS: Aging;Atherosclerosis;Autoimmune Disease;Cardiovascular;Clinical Research;Diabetes;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

PHR: PROJECT NARRATIVE This proposal aims to characterize the clinical, biochemical, structural and functional properties of cardiovascular diseases in people with type 1 diabetes (T1D). In addition, we will also evaluate the morphological properties of atherosclerotic plaques from the coronary and tibial arteries of people with T1D and type 2 diabetes, as well as evaluate whether autoimmunity can affect the severity of atherosclerosis in T1D. This data will fulfill knowledge gaps in people with T1D and will be critical for designing future treatments for CVD in T1D.

PI_NAMEs: KING, GEORGE L (contact)

PROGRAM_OFFICER_NAME: KIRBY, RUTH

PROJECT_TERMS: Acceleration;Affect;Aging;Alleles;Animal Model;Anti-Hypertensive Agents;Apolipoprotein E;Apoptotic;Area;Arterial Fatty Streak;Arteries;Atherosclerosis;atherosclerosis risk;Autoantibodies;Autoimmune;Autoimmune Diabetes;Autoimmune Diseases;Autoimmunity;Autopsy;B-Lymphocytes;Beta Cell;biobank;Biochemical;C-Peptide;calcification;Calcium;cardiac magnetic resonance imaging;Cardiac Myosins;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Caring;CD3 Antigens;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Characteristics;Clinical;clinical risk;cohort;comparative;Comparative Study;contrast enhanced;Coronary artery;coronary calcium scoring;Coronary Vessels;CRISPR/Cas technology;cytokine;Data;design;Development;Diabetes Mellitus;Diabetic Nephropathy;disease phenotype;Disease Progression;Dyslipidemias;Electrocardiogram;Exhibits;experience;Future;Gender;Genes;genome editing;glycemic control;Heart;Heart failure;heart imaging;High Density Lipoproteins;High Fat Diet;high risk;Human;Hyperglycemia;Hyperlipidemia;Hypertension;illness length;Image;Immune;immune cell infiltrate;improved;Inbred NOD Mice;Inflammation;Inflammatory;inflammatory marker;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;insulitis;Islet Cell;Kidney;Kidney Diseases;Knowledge;Laboratories;Lipids;Macrophage;male;Medical;Metabolic Control;Metabolic Pathway;metabolomics;Microvascular Dysfunction;monocyte;Mononuclear;Morphology;mortality;Mus;Myocardial;myocardial damage;Myocardial dysfunction;Myocardial Infarction;Myocardial Ischemia;Necrosis;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Onset of illness;Organ;Pathogenesis;Pathologic;Pathology;Patient Self-Report;Patients;Peripheral;Persons;Pilot Projects;Plasma;Population;Prediabetes syndrome;Property;Publishing;Recording of previous events;Regulatory T-Lymphocyte;Reporting;research clinical testing;response;Retinal Diseases;Risk Factors;risk variant;Role;Sampling;Senile Plaques;Serum;Severities;Specimen;Stains;Structure;T-Lymphocyte;T-Lymphocyte Subsets;Tibial Arteries;type I and type II diabetes

PROJECT_TITLE: Characterization of cardiovascular diseases (CVD) in people with long duration Type 1 diabetes


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Title: Analysis of calcium signaling in C. elegans Narrative: This proposal describes a coherent set of genetic, molecular, and biophysical experiments to determine how voltage-activated calcium (CaV) channels are coupled to their downstream effectors in neurons and muscles. CaV activation of effectors controls action potential firing patterns, muscle contraction, activity regulated gene transcription, and neurotransmitter and neuropeptide secretion. Thus, these Aims address fundamental aspects of neuron and muscle biology.

PI_NAMEs: KAPLAN, JOSHUA M (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Action Potentials;Address;Binding Proteins;Biology;Biophysics;Caenorhabditis elegans;Calcineurin;Calcium;Calcium Channel;Calcium Signaling;Calmodulin;Candidate Disease Gene;cell type;Cells;Coupled;Coupling;CREB1 gene;Cytoplasm;Defect;Endoplasmic Reticulum;Enzymes;experimental study;Frequencies;Genes;Genetic;Genetic Transcription;Goals;HDAC4 gene;Histone Deacetylase;Homeostasis;insight;large-conductance calcium-activated potassium channels;Mediating;Membrane;millisecond;Modeling;Molecular;Motor Neurons;Muscle;Muscle Contraction;Muscle function;muscle physiology;mutant;Mutation;mutation screening;nano;nanometer;Nervous System Disorder;Neuromuscular Junction;Neurons;Neuropeptides;neurotransmitter release;Neurotransmitters;optogenetics;Pathologic;Pattern;Phosphotransferases;Play;postsynaptic;Potassium Channel;Presynaptic Terminals;Probability;Protein Kinase;Protein phosphatase;Receptor Activation;receptor coupling;recruit;response;Role;Ryanodine Receptor Calcium Release Channel;Signal Transduction;Source;Speed;Synapses;synaptic function;Synaptic Receptors;Testing;Time;transcription factor;voltage

PROJECT_TITLE: Analysis of Calcium Signaling in C. Elegans

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences;Pediatric;Social Determinants of Health

PHR: Project Narrative In this project we seek to recruit and train minority high-school students who, in many cases, are the first in their family seeking to attend college. Our aim will be to facilitate this goal by giving them a broad array of STEM-related (Science, Technology, Engineering, and Math) training and helping them construct an open- source dataset of labeled brain structures freely available to the public and learning community, then publish a scientific paper at the end of each summer detailing the results and distributing the data.

PI_NAMEs: FISCHL, BRUCE  (contact);PRICE, JULIE C

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Admission activity;age effect;Alzheimer's Disease;Anatomy;Area;Behavioral Sciences;Biomedical Engineering;Biomedical Research;Boston;Brain;Brain imaging;Brothers;career;Chronic;Clinical;Clinical Sciences;Cognitive;Cognitive Science;cohort;college;computer science;Data;Data Analyses;Data Set;Dedications;Discipline;Disease;distributed data;Education;Educational Curriculum;Ethics;Exposure to;Faculty;Family;Funding;Goals;High School Student;Image;interest;Internships;Journals;Label;Learning;learning community;lectures;Life;Low income;Manuals;Medical Imaging;Mentors;Mentorship;Minority;minority communities;Motor;neuroimaging;Neurology;Neurosciences;open data;Outcome;Outcome Measure;outreach;Paper;people of color;Persons;Physics;Play;programs;project-based learning;prototype;Psyche structure;Psychiatry;Publishing;Radiology Specialty;recruit;Research;Research Personnel;responsible research conduct;Rest;Role;Running;Science, Technology, Engineering and Mathematics;Secure;Sensory;Series;social;STEM field;Stress;Structure;student training;Students;summer internship;Talents;Training;underserved community;underserved students;Work;Writing

PROJECT_TITLE: MGH/HMS Internship in NeuroImaging Analysis


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Women's Health Research

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CITY COLLEGE OF NEW YORK

PHR: NARRATIVE The goal of this project is to detect breast cancer as early as possible while limiting the burden of screening in high-risk women. To this end, risk will be estimated from magnetic resonance images of the breast as well as mammograms using deep learning techniques. A retrospective analysis of a very large dataset will determine if some women could have avoided unnecessary scans without missing newly developing cancers.

PI_NAMEs: PARRA, LUCAS C (contact);SUTTON, ELIZABETH J

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: 3-Dimensional;Address;Adoption;Algorithms;Appearance;Breast;Breast Cancer Detection;breast cancer diagnosis;Breast Cancer Risk Factor;breast imaging;Breast Magnetic Resonance Imaging;Cancer Center;cancer therapy;Cancerous;Classification;Clinical;Clinical Investigator;clinical research site;cohort;convolutional neural network;cost;Data;data curation;data exchange;Data Set;data sharing;Databases;deep learning;Detection;Diagnosis;Diagnostic;DNA Sequence Alteration;Family;Family history of;follow-up;Fostering;Future;Gadolinium;Genomics;Goals;high risk;High Risk Woman;Human;Image;imaging modality;Individual;individualized prevention;Label;large datasets;Learning;Lesion;lifetime risk;Link;Location;Machine Learning;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;Manuals;Medical Imaging;Memorial Sloan-Kettering Cancer Center;Methods;Modeling;Modernization;MRI Scans;Mutation;Outcome;Pathology;Patients;Performance;Population;predictive modeling;primary outcome;quality assurance;radiologist;Reader;Recommendation;Recording of previous events;Resolution;Resources;Risk;Risk Adjustment;Risk Assessment;Risk Estimate;Risk Factors;risk prediction;risk prediction model;risk stratification;Scanning;Schedule;screening;screening program;Site;Slice;Software Tools;Subgroup;symposium;Techniques;Technology;technology platform;Testing;The Cancer Imaging Archive;Time;tool;Training;transfer learning;tumor;Universities;Validation;Vision;Woman;Work

PROJECT_TITLE: Machine learning for risk-adjusted breast MRI screening

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Women's Health Research

ORG_CITY: Loma Linda

ORG_NAME: LOMA LINDA UNIVERSITY

PHR: PROJECT NARRATIVE Hypertensive disorders of pregnancy, including preeclampsia, have devastating effects on the maternal cardiovascular system, are leading causes of maternal deaths, and increase risk for future cardiovascular disease. The proposed research is expected to lead to the discovery of novel mechanisms that contribute to the etiology of maternal vascular dysfunction in pregnancies with preeclampsia. This contribution will be important in the development of pharmacological strategies that will allow the inhibition of interactions between placenta-derived factors and the maternal vascular system, alleviating the symptoms of preeclampsia and reducing cardiovascular risk so all women can live longer and more fulfilling lives.

PI_NAMEs: GOULOPOULOU, STYLIANI  (contact)

PROGRAM_OFFICER_NAME: GALIS, ZORINA S

PROJECT_TERMS: Address;Animal Model;Arteries;Autophagocytosis;Blood Pressure;Blood Vessels;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cell Death;Cell Death Induction;Cells;Circulation;Clinical;Clinical Research;clinically relevant;CpG dinucleotide;Data;Developed Countries;Development;Endothelium;Etiology;Exposure to;extracellular;Extracellular Space;Functional disorder;Future;Generations;Human;Hypertension;hypoperfusion;Hypoxia;immunogenic;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;innovation;Ischemia;Knowledge;Link;Maintenance;Maternal Mortality;Methods;Mitochondria;Mitochondrial DNA;Modeling;Molecular;novel;Oligodeoxyribonucleotides;Oxidative Stress;Pathogenesis;Pathogenicity;Pathway interactions;pharmacologic;Physiology;Placenta;Plasma;pre-clinical;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy disorder;pregnant;prevent;Property;Rattus;Reactive Oxygen Species;reduce symptoms;release factor;Research;response;Risk;Role;Signal Transduction;stressor;Syndrome;Testing;Theoretical model;therapy design;Time;tissue injury;TLR2 gene;TLR9 gene;translational impact;trophoblast;United States;Vascular Diseases;Vascular System;Woman

PROJECT_TITLE: Maternal vascular responses to extracellular mitochondrial DNA during pregnancy

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


NIH_SPENDING_CATS: Genetics

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative The self-organizing, reaction-diffusion mechanism underlies the developmental process of a wide range of vertebrate traits, including embryonic axis specification, lung branching, palatal rugae formation, hair follicle spacing, and digit patterning, all directly relevant to human health. This project aims to elucidate the molecular details of a two-component reaction-diffusion system that controls the formation and evolution of self-organizing pigmentation patterns. Findings from this project will provide important insights towards understanding how the reaction-diffusion mechanism generates self-organizing spatial patterns during the development of multicellular organisms in general.

PI_NAMEs: YUAN, YAOWU  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Affect;Alleles;Animals;Anthocyanins;base;Binding;Biological;Biological Models;biological systems;Biology;biophysical properties;Candidate Disease Gene;cell fate specification;Cells;Chromosome Mapping;Color;Complex;Computer Simulation;Development;Developmental Process;Diffusion;Digit structure;Distant;Embryo;Evolution;Exhibits;experimental study;Feedback;Flowers;fluorescence imaging;Genes;Genetic;genetic analysis;genetic manipulation;Genetic Transcription;Goals;Hair follicle structure;Hair Root;Health;Human;inhibitor;Insecta;insight;Lung;mathematical model;Mathematics;Mimulus;Modeling;Molecular;morphogens;Mouse-ear Cress;Movement;mutant;Mutation;Nature;Organism;Pattern;Pattern Formation;Phenotype;Pigmentation physiologic function;Pigments;plant genetics;Plants;Process;Property;Proteins;Reaction;Regulatory Element;Role;self organization;simulation;Specific qualifier value;Spottings;System;Testing;Time;Tissues;trait;transcription factor;Transgenic Organisms;Translating;Undifferentiated;Variant;Vertebrates;virtual;Wing;Work

PROJECT_TITLE: Development and evolution of self-organizing pigmentation patterns

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE Spore germination is necessary for many bacterial pathogens, particularly anaerobes, to initiate infection. A critical step during germination is the degradation of the cortex, a thick layer of modified peptidoglycan that maintains metabolic dormancy. Digestion of this protective layer is mediated by cortex lytic enzymes that recognize the spore-specific peptidoglycan modification, muramic-∂-lactam. As a result, mutants lacking muramic-∂-lactam fail to degrade their cortex layer and exhibit severe defects in germination. Previous work in Bacillus subtilis has shown that muramic-∂-lactam is generated through the sequential action of the CwlD amidase and PdaA deacetylase, which are conserved in all spore-forming bacteria. While B. subtilis CwlD has intrinsic amidase activity, we recently determined that the CwlD amidase produced by the bacterial pathogen, Clostridioides difficile, requires the GerS lipoprotein to deamidate N-acetylmuramic acid residues. Notably, GerS is only conserved in members of the Peptostreptococcaceae family, and our preliminary data indicate that only CwlD homologs from the Peptostreptococcaceae family can complement a C. difficile ?cwlD mutant, while B. subtilis and C. perfringens CwlD homologs cannot. These observations suggest that the Peptostreptococceae family uses an alternative mechanism to mediate cortex modification during spore formation. Since our data also indicate that GerS and CwlD interact stoichiometrically, and we have recently crystallized this complex, the goal of this proposal is to determine the mechanism by which GerS regulates CwlD amidase function in C. difficile. We will test the hypothesis that GerS binding to CwlD allosterically activates CwlD function and distinguish between different models for why C. difficile CwlD function depends on GerS. These models include that GerS (i) functions as a co-factor to license CwlD’s amidase activity, recruits CwlD to the forespore, and/or (ii) facilitates CwlD’s recognition of C. difficile’s unique cortex structure. To accomplish these goals, we will use mutational analyses, heterologous expression systems, biochemical analyses, and cell biological techniques to determine the requirements for not only C. difficile CwlD amidase activity but also B. subtilis CwlD amidase function. These comparative analyses will provide mechanistic insight into the regulation of cortex modification in spore-forming bacteria. The proposed work may also expand our understanding of how bacterial amidases can be allosterically regulated by binding partners.

PI_NAMEs: SHEN, AIMEE  (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Acute;Affect;amidase;Anaerobic Bacteria;Attenuated;Bacillus subtilis;Bacteria;Bacterial Spores;Binding;Biochemical;Biological;Biological Assay;Cell Wall;Cells;Centers for Disease Control and Prevention (U.S.);Chimeric Proteins;Clostridium difficile;Clostridium perfringens;cofactor;comparative;Complement;Complex;Crystallization;Data;Deacetylase;deamidation;Defect;Dependence;Development;Digestion;disease transmission;Enzymes;Escherichia coli;Exhibits;Family;Family member;Fluorescence Resonance Energy Transfer;Genome;Germination;Goals;Growth;Healthcare Systems;Homologous Gene;In Vitro;Individual;Infection;insight;Lactams;Licensing;Lipoprotein (a);Lipoproteins;Location;LytA enzyme;Measures;Mediating;member;Membrane;Metabolic;Modeling;Modification;mutant;Mutation;Mutation Analysis;N-acetylmuramic acid;pathogen;pathogenic bacteria;Pattern;Peptidoglycan;Physiology;Predisposition;prevent;Process;Proteins;Recording of previous events;recruit;Recurrence;Recurrent disease;Regulation;Reporter;Reproduction spores;Role;Structure;System;Techniques;Testing;Thick;Virulence;Work;Zinc

PROJECT_TITLE: Regulation of spore peptidoglycan modification

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Lung;Prevention;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

PHR: PROJECT NARRATIVE The reason why some develop exposure related diseases, such as the scarring lung disease chronic beryllium disease, while others do not is not well understood. This proposal may help explain why some people get CBD, while also defining drivers and new genes important in the development of this and other similar diseases, as well as helping us understand how beryllium exposure may change these drivers and genes. In future studies, these factors may serve as biomarkers or predictors of disease and ultimately even targets for therapy.

PI_NAMEs: MAIER, LISA A (contact);YANG, IVANA V

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: airway epithelium;Alleles;Amino Acids;Antigen Presentation;Antigen-Presenting Cells;Antigens;asthmatic airway;Berylliosis;Beryllium;Biological Markers;biomarker identification;Bronchoalveolar Lavage;CD4 Positive T Lymphocytes;Cell Culture Techniques;Cell Differentiation process;Cell Line;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chemokine;Chromatin;Chronic berylliosis;COVID-19;cytokine;Data;Development;Disease;disorder risk;DNA analysis;DNA Methylation;Drug Targeting;Environment;Environmental Exposure;Epigenetic Process;epigenome;Epitopes;Etiology;Exposure to;fibrotic lung;Flow Cytometry;Future;Gene Expression;Genes;Genetic;Genetic Polymorphism;Genetic Predisposition to Disease;Genomic approach;Glutamic Acid;Goals;Granuloma;Granulomatous;granulomatous lung disease;Health;Heritability;histone modification;HLA-DPB1 gene;Hour;Immune;Immune response;Immune Response Genes;Inflammation;Inhalation;Inherited;Innate Immune Response;Investigation;Life;Lung;Macrophage;Measures;Mediating;member;Methods;Methylation;Modification;Molecular;multiple omics;neoantigens;novel;Organ;Pathogenesis;Pathogenicity;Pathway interactions;peripheral blood;Persons;Population;Positioning Attribute;Predisposition;Prevalence;Proliferating;Proteins;Pulmonary Fibrosis;recruit;Regulation;Regulatory Pathway;response;Risk;Risk Factors;Sampling;single cell ATAC-seq;single cell sequencing;Site;Structure of parenchyma of lung;System;T-Lymphocyte;targeted treatment;Technology;Testing;Time;Transcriptional Regulation;transcriptome;transcriptome sequencing;Validation;Variant;Work;XCL1 gene

PROJECT_TITLE: Using Multi-Omics to Define Regulators and Drivers of Granulomatous Inflammation and Chronic Beryllium Disease

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Differential regulation of growth factor signaling in endothelial cells that line blood vessels is important for formation of blood vessel networks during embryonic development. Once blood vessels form, this differential regulation is equalized among endothelial cells and reduced so vessels can function as conduits for oxygen and nutrients. However, vessels can respond quickly to reinitiate differential signaling and form new vessel networks in some situations, for example during wound healing. This work will study those states, ask how endothelial cells respond appropriately, and determine what changes during the transition periods lead to different signaling outcomes, thus setting the stage for new ideas for therapeutic interventions in diseases involving blood vessels.

PI_NAMEs: BAUTCH, VICTORIA L (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: angiogenesis;blood vessel development;Blood Vessels;Cardiovascular Diseases;cell behavior;Cell Line;Development;Disease;Embryonic Development;Endothelial Cells;Gene Expression;Goals;Growth Factor;Heterogeneity;Homeostasis;Inflammation;Knowledge;Lead;mechanical signal;Mediating;Modeling;Molecular;notch protein;novel;Nutrient;Outcome;Output;Oxygen;Pathway interactions;Physiological;Process;Proteins;Regulation;Repression;response;Role;shear stress;Signal Pathway;Signal Transduction;Testing;Therapeutic Intervention;tool;Variant;Vascular Endothelial Growth Factors;Work;wound healing

PROJECT_TITLE: MOLECULAR AND CELLULAR CONTROL OF ANGIOGENESIS


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Host attachment and virus entry are key steps in the virus life cycle that can be targeted by future antiviral compounds. This application aims to identify the mechanism and inhibition of Thogotovirus entry and class III fusion protein function.

PI_NAMEs: BOON, ADRIANUS CM (contact);FREMONT, DAVED H.;WHELAN, SEAN PJ

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acids;Affinity;Amblyomma;Ambylomma americanum;Animals;Anti-viral Agents;Antibodies;Antibody Repertoire;arboviral disease;Area;B-Lymphocytes;Baculoviruses;Binding;Biochemical;Biological Assay;biophysical techniques;Bourbon virus;burden of illness;Cell fusion;Cell membrane;Cell-Matrix Junction;Cells;Ceramide glucosyltransferase;Chimeric Proteins;climatic factors;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Complement;Complex;County;Coupled;CRISPR-mediated transcriptional activation;cross reactivity;Cryoelectron Microscopy;Data;Demographic Factors;Disease;disease model;efficacy testing;emerging virus;env Gene Products;Epitopes;Escape Mutant;experimental study;Flavivirus;flavivirus glycoprotein E;Future;Genetic;genetic approach;genetic information;glycoprotein G;Glycoproteins;Glycosphingolipids;group competition;Hand;Human;human disease;human pathogen;Image;Imaging Device;Immunity;Immunize;Incidence;Individual;Infection;Influenza Hemagglutinin;inhibiting antibody;insight;Integration Host Factors;Kansas;Kinetics;Knock-out;Life Cycle Stages;Mammalian Cell;Maps;Mediating;Membrane Fusion;Membrane Glycoproteins;Midwestern United States;Missouri;Molecular Cloning;Molecular Conformation;Monoclonal Antibodies;mouse model;Mus;mutant;Natural Immunity;neutralizing antibody;Null Lymphocytes;particle;Pathway interactions;Patients;pharmacologic;Process;Productivity;protective efficacy;protein function;Proteins;Rabies virus;Reagent;receptor;Receptor Cell;Reporter;Resistance;response;Rhabdoviridae;Role;Serum;Simplexvirus;Site;Sorting;Structure;success;synergism;Testing;therapeutic target;Thogotovirus;tick transmission;Ticks;tool;transmission process;United States;unpublished works;uptake;vaccine development;vector mosquito;vector transmission;Vesicular stomatitis Indiana virus;Viral;Viral Envelope Proteins;Viral Fusion Proteins;Viral Physiology;viral RNA;Virion;Virus;Virus Diseases

PROJECT_TITLE: Mechanism and Inhibition of Thogotovirus Entry

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE Evolutionarily conserved proteins are enriched for disease traits and are abundant across human cell types and tissues. A large portion of these deeply conserved genes are known to responsible for a large and diverse subset of major human diseases, spanning developmental disorders (e.g., Noonan syndrome, Leigh syndrome, microcephaly, neural tube defects), cancers (e.g., leukemia, breast cancer, colorectal cancer), chronic respiratory diseases (e.g., ciliary dyskinesia, asthma), neurological disorders (e.g., Charcot-Marie-Tooth disease, encephalopathy, schizophrenia, autism) and motor problems (e.g., dystonia, spastic paraplegia). By querying the protein interactions of deeply conserved human genes using a comparative proteomics approach, we can potentially discover disease associations and new functions for poorly characterized human genes, helping to better characterize the human proteome.

PI_NAMEs: COX, RACHAEL M (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Animals;arm;Asthma;autism spectrum disorder;Automobile Driving;Back;Biochemical;bioinformatics pipeline;Biological Process;Biology;Candidate Disease Gene;causal variant;cell type;Charcot-Marie-Tooth Disease;chronic respiratory disease;Cilia;Ciliary Motility Disorders;ciliopathy;cilium motility;Collaborations;Colorectal Cancer;comparative;Complex;computing resources;Confocal Microscopy;Data;Data Set;Defect;developmental disease;Diatoms;Disease;disease model;Dynein ATPase;Dystonia;Embryo;Encephalopathies;Eukaryota;experimental study;Fractionation;Functional disorder;gene conservation;Gene Family;Genes;Genetic;Genetic Diseases;Golgi Apparatus;Guilt;Hand;Human;human disease;Human Genetics;Human Genome;improved;Kidney Diseases;knock-down;Leigh Disease;leukemia;Life;Link;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measures;Microcephaly;Modeling;Molecular;Motility;Motor;motor disorder;multicatalytic endopeptidase complex;Nerve Degeneration;Nervous System Disorder;Neural Tube Defects;Noonan Syndrome;novel;Organelles;Organism;Paper;Phenotype;Plant Proteins;Plants;Polydactyly;Primary Ciliary Dyskinesias;Productivity;promoter;protein complex;protein crosslink;protein protein interaction;Proteins;Proteome;Proteomics;Rana;Reporting;Research;Retinal Degeneration;RNA-Protein Interaction;Role;Sampling;Schizophrenia;skills;Spastic Paraplegia;Taxonomy;Techniques;Testing;Tissues;trait;Trees;trend;Validation;Xenopus

PROJECT_TITLE: Leveraging comparative proteomics to improve human disease models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE  While astrocytes are now recognized as integral neural circuit components, a fundamental description of their input-output function—and a comprehensive understanding of astrocytic responses to major neurotransmitters—remains elusive. In this proposal, we focus on astrocytic responses to three major neurotransmitters to ask how neurotransmitter-specific activity leads to cell- and network-level activity across three progressive neurobiological scales. Our results will illuminate mechanisms by which astrocytes encode neurotransmitter signals and coordinate neural populations across the cerebral cortex.

PI_NAMEs: FEINBERG, EVAN HARRIMAN (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Address;Affect;Area;Astrocytes;Automobile Driving;Behavior;Benchmarking;Brain;Brain region;Calcium;Calcium Signaling;Cell surface;Cells;Cerebral cortex;Communication;Computer Analysis;Cyclic AMP;Data;Decision Making;Disease;Electrophysiology (science);Feedback;Fiber;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;Genetic;genetic manipulation;Genetic Techniques;Giant Cells;Glutamates;Goals;Health;Human;Image;in vivo;Individual;intercalation;Knowledge;Maps;Mediating;Motor output;mouse model;multiscale data;neural;neural circuit;Neurobiology;Neuromodulator;Neuromodulator Receptors;neuronal circuitry;Neurons;neurotransmission;Neurotransmitter Receptor;Neurotransmitters;noradrenergic;Norepinephrine;Optics;Outcome;Outcomes Research;Output;Pattern;Photometry;Physiological;Physiology;Population;Process;Research;response;Second Messenger Systems;Sensory;Shapes;Signal Transduction;Slice;spatiotemporal;Synapses;System;Taxonomy;Testing;Tissues;transmission process;two-photon;Work

PROJECT_TITLE: A Functional Taxonomy of Cortical Astrocytes

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The completion of this proposal will lead to a better understanding of ubiquitin-based regulation of B-cell lymphoma onset and progression. Defining the molecular mechanism that links ubiquitin signaling pathway with protein degradation and gene expression, and establishing the importance of such regulation in cancer, will be critical for generating effective personalized therapeutic approaches.

PI_NAMEs: BUSINO, LUCA  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Accounting;Agammaglobulinaemia tyrosine kinase;aged;Alleles;Animals;B lymphoid malignancy;B-Cell Antigen Receptor;B-Cell Lymphomas;B-Lymphocytes;BCL6 gene;Binding;Biological;Bortezomib;cancer cell;Cancer Etiology;Cell Line;Cell Proliferation;cell transformation;Cells;Cessation of life;Chemicals;Clinical;Complex;Coupled;Cyclophosphamide;Data;Development;Doxorubicin;Drug resistance;FDA approved;gain of function mutation;gamma secretase;Gene Expression;Genes;genetic signature;Genetic Transcription;Glues;Goals;Growth;Hematological Disease;Human;Impairment;in vivo;Inflammation;inhibitor;Investigation;Knock-out;Knockout Mice;large cell Diffuse non-Hodgkin's lymphoma;Link;Lymphoma;Lymphoma cell;Lymphomagenesis;Lymphoproliferative Disorders;Malignant Neoplasms;Mature B-Lymphocyte;Membrane;Modeling;Molecular;mouse model;multicatalytic endopeptidase complex;Mus;Mutate;Mutation;Neoplasms;Non-Hodgkin's Lymphoma;NOTCH1 gene;novel;Oncogenic;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;Penetrance;personalized therapeutic;Phenotype;Prednisone;programs;Proliferating;Proteasome Inhibitor;protein degradation;Receptor Inhibition;Receptor Signaling;Recurrence;Refractory;Regimen;Regulation;Relapse;Reporting;Resistance;rituximab;Role;scaffold;Series;Signal Pathway;Signal Transduction;success;Therapeutic;Treatment Efficacy;tumor;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenesis;Tyrosine Kinase Inhibitor;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Up-Regulation;Vincristine;Xenograft procedure

PROJECT_TITLE: Role of KLHL6 inactivation in mature B-cell malignancies


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Patient Safety;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: FAMILY HEALTH INTERNATIONAL

PHR: PROJECT NARRATIVE The global HIV epidemic affects the lives of millions of individuals around the world, many of whom face stigma, discrimination, poverty and other challenges. The HIV Prevention Trials Network (HPTN) aims to advance the discovery of new prevention tools while striving to overcome the barriers inhibiting the optimal use and benefit of existing efficacious tools. The proposed research will be conducted at sites around the world and in partnership with researchers and community members.

PI_NAMEs: COHEN, MYRON SCOTT (contact);EL-SADR, WAFAA M.

PROGRAM_OFFICER_NAME: DEJLI, JAMAL

PROJECT_TERMS: Address;Adherence;Adolescent;Adverse effects;Affect;Africa South of the Sahara;AIDS prevention;Anti-Retroviral Agents;appropriate dose;Behavior Therapy;Behavioral;Behavioral Research;Binding Sites;Characteristics;clinical research site;Clinical Trials;Collaborations;Communities;community partners;Complement;Contraceptive methods;data integration;data modeling;design;Devices;Discrimination;drug development;Drug Interactions;Drug Kinetics;Effectiveness;effectiveness evaluation;Epidemic;Evaluation;Face;Failure;female sex worker;Geography;Goals;Health;High Risk Woman;HIV;HIV Infections;HIV prevention trials network;HIV Vaccine Trials Network;Implant;Incidence;Individual;Infusion procedures;Injectable;Injecting drug user;Injections;Intervention;Leadership;mathematical model;medication safety;member;men who have sex with men;Methods;Molecular;Needles;neutralizing antibody;New Agents;novel;operation;Opiate Addiction;Oral;Oral Contraceptives;Participant;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Phase;phase 1 designs;phase 2 study;phase 3 study;Phylogeny;Play;Population;Populations at Risk;Poverty;pre-exposure prophylaxis;preference;Pregnancy;Pregnant Women;prevent;Prevention;Prevention strategy;preventive intervention;Process;Process Measure;product development;Public Health;Randomized;Research;Research Design;Research Personnel;Safety;Sexually Transmitted Diseases;Site;Social Behavior;social stigma;Specificity;success;System;Technology;Testing;tool;transgender women who have sex with men;transmission process;United States National Institutes of Health;Vaginal Ring;Viral;viral resistance;Woman;young man;young woman

PROJECT_TITLE: HIV Prevention Trials Network Leadership and Operations Center


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE A summer research program in environmental health and toxicology will provide opportunities for underrepresented minority students to receive first time mentored introductory experiences in laboratory research. Coupled with professional development activities aimed at improving both verbal and written scientific communication, introduction to research career opportunities in environmental health and ethical conduct of research, the proposed program should prepare the student for a more extensive subsequent research experience.

PI_NAMEs: BERNARD, JAMIE J;LUYENDYK, JAMES P (contact)

PROJECT_TERMS: Ally;Area;career;Career Choice;career development;Chronic Disease;Communication;Communities;Coupled;Development;Disincentive;Doctor of Philosophy;Educational Activities;Enrollment;environmental agent;Environmental Health;Environmental Science;environmental toxicology;Ethics;experience;Exposure to;Extramural Activities;Faculty;Foundations;Funding;gene environment interaction;Goals;graduate student;Hispanic;Historically Black Colleges and Universities;improved;Individual;innovation;Institution;Instruction;interest;Investigation;Laboratory Research;Medical;meetings;mentoring community;Mentors;Michigan;Minority Groups;minority scientist;Minority-Serving Institution;Mission;National Institute of Environmental Health Sciences;Native Americans;North Carolina;Oral;Outcome;Participant;Positioning Attribute;posters;Process;programs;Puerto Rico;Qualifying;recruit;Research;Research Personnel;Research Project Grants;Research Training;Resources;responsible research conduct;role model;Schools;Science;Series;skills;social;Societies;Student Selections;Students;summer program;summer research;System;Time;Toxic effect;Toxic Environmental Substances;Toxicology;Training;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;Universities;verbal;Visit;wasting;Woman;Work;Writing

PROJECT_TITLE: First Time Summer Research Experience in Environmental Health Sciences


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Patient Safety;Prevention;Rare Diseases;Tuberculosis;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE The HIV pandemic is an immense threat to health and development. This Clinical Trials Unit, that partners Vanderbilt University Medical Center and Washington University at St Louis, will contribute to the missions of the AIDS Clinical Trials Group, HIV Vaccine Trials Network, and HIV Prevention Trials Network.

PI_NAMEs: HAAS, DAVID W (contact);KALAMS, SPYROS A;PRESTI, RACHEL MARGARET

PROGRAM_OFFICER_NAME: JALLAH, ODAV MARDEA

PROJECT_TERMS: Academic Medical Centers;Acquired Immunodeficiency Syndrome;Affect;AIDS clinical trial group;AIDS prevention;Antibody titer measurement;antiretroviral therapy;Area;Behavioral;Biological;clinical research site;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;Collaborations;Communities;comorbidity;Contraceptive methods;Country;County;Data;design;Development;diagnostic technologies;Disease;drug-sensitive;Enrollment;Ensure;Epidemic;Epidemiology;Event;Funding;Health;Hepatitis B Virus;HIV;HIV Infections;HIV prevention trial;HIV prevention trials network;HIV vaccine;HIV Vaccine Trials Network;HIV-1;HIV/AIDS;human genomics;Immune response;Immunologics;Immunology;improved;Incidence;Infection;Institution;Intervention;Leadership;Licensure;Maps;member;Metabolic;Metagenomics;Mission;Missouri;Modeling;Molecular;Molecular Biology;Molecular Immunology;National Institute of Allergy and Infectious Disease;Neurologic;neutralizing antibody;novel;novel vaccines;opioid use disorder;pandemic disease;Participant;participant enrollment;participant safety;Passive Immunization;Performance;Persons;Pharmacogenomics;Phase;Play;Populations at Risk;Positioning Attribute;pre-exposure prophylaxis;Prevalence;prevent;Prevention;Prevention Research;preventive intervention;Productivity;programs;Protocols documentation;Records;recruit;Research;Research Design;Resistance;response;Risk;Role;Rural;Science;Severities;Sexually Transmitted Diseases;Site;Social Behavior;success;System;Techniques;Technology;Tennessee;Testing;Therapeutic;Tuberculosis;Tuberculosis Vaccines;United States;Universities;vaccine candidate;vaccine response;Vaccines;Viral hepatitis;Viral Load result;Virus Diseases;Washington

PROJECT_TITLE: Vanderbilt HIV Clinical Trials Unit (CTU)


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;HIV/AIDS;Immunization;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: A safe and effective HIV vaccine is needed to halt the pandemic. We will conduct high-quality laboratory studies on behalf of the HTVN that can inform the field about what a candidate HIV vaccine can and cannot do in the populations who would benefit most. Our efforts will provide a rich database that will help advance vaccine development for HIV and other globally important pathogens, such as TB.

PI_NAMEs: MCELRATH, MARGARET JULIANA (contact)

PROGRAM_OFFICER_NAME: D'SOUZA, PATRICIA D

PROJECT_TERMS: Acceleration;adaptive immunity;Adult;age group;AIDS prevention;Antibodies;Biological Assay;Blood;Child;Childhood;Clinical;Clinical Research;Clinical Trials;Collaborations;Data Coordinating Center;Databases;Decision Making;Development;efficacy trial;first-in-human;Genetic;Goals;HIV;HIV Infections;HIV vaccine;HIV Vaccine Trials Network;Human;Immune;immune function;Immune response;Immunity;Immunology;improved;Infection;Infrastructure;Innate Immune Response;innovation;insight;Investigation;Kinetics;Laboratories;Laboratory Study;Lead;Leadership;Measurement;Methods;Monitor;Monoclonal Antibodies;Mucosal Immune Responses;Mycobacterium tuberculosis;Natural Immunity;operation;pandemic disease;pathogen;Phase;Population;practice setting;prevent;Prevention strategy;programs;Prophylactic treatment;Public Health;Qualifying;Regimen;research study;response;Risk;Route;Schedule;Science;Specific qualifier value;Specificity;Structure;Testing;tool;Vaccination;vaccine candidate;Vaccine Clinical Trial;vaccine development;vaccine efficacy;vaccine evaluation;vaccine immunogenicity;vaccine platform;vaccine-induced antibodies;Vaccines;virus genetics

PROJECT_TITLE: HIV Vaccine Trials Network Laboratory Center


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Sarcopenia

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Aging organisms show impaired redox homeostasis and a blunted ability to respond to redox stressors. This is associated with declining stress resilience and increased risk for age-associated diseases. We propose to manipulate the chronic mitochondrial redox stress in models of acute and chronic exercise in young and aged mice to test whether mitochondrial dysfunction underlies the decreased adaptive response with age that drives the decline in muscle function and healthspan.

PI_NAMEs: OSTROM, ETHAN LAMBERT (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acceleration;Achievement;Acute;acute stress;Affect;Age;age related changes;age related decline;age-related disease;aged;Aging;aging process;Antioxidants;Attenuated;Automobile Driving;Binding;biological adaptation to stress;Cells;cellular resilience;Cessation of life;Chemistry;Chronic;Chronic stress;Communication;Disease;Equilibrium;Exercise;exercise training;functional improvement;Future;Gene Expression;Genetic Models;gerotherapeutic;Glutathione Disulfide;habituation;healthspan;Homeostasis;Human;Impairment;improved;In Vitro;in vivo;Individual;insight;Intervention;knock-down;Knowledge;loss of function;Measures;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Mus;Muscle;muscle aging;Muscle Contraction;Muscle function;old mice;Organ;Organism;oxidant stress;Oxidants;oxidation;Oxidation-Reduction;Pathologic;Pathology;Pathway interactions;Performance;Pharmacologic Substance;physiologic stressor;Physiological;poor health outcome;Process;Production;Proteins;Proteome;Proteomics;Quality of life;Reactive Oxygen Species;Research;resilience;resilience in aging;Resolution;response;Response Elements;Rest;Risk;Role;Signal Pathway;Signal Transduction;Site;Skeletal Muscle;SOD2 gene;Source;Stress;stress resilience;Stress Response Signaling;stressor;Sulfhydryl Compounds;System;Testing;therapeutic target;Training;transcription factor;treatment comparison;Work;young adult

PROJECT_TITLE: The role of mitochondrial redox stress in the impaired Nrf2 response to contraction in aged muscle


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Complementary and Integrative Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation

ORG_CITY: LOS ANGELES

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative: This project will further our understanding of recurrent laryngeal nerve neuropraxia, one of the most common forms of nerve injury during neck surgery. We will explore a new method of targeted and prolonged topical drug delivery for its ability to improve the time to functional recovery after neuropraxia. This will allow for the development of a therapeutic to reduce dysphonia and preserve vital airway protection mechanisms after this injury.

PI_NAMEs: KITA, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Acids;Action Potentials;Affect;Anesthesia procedures;Animal Model;aspirate;Award;Axon;Biomedical Engineering;Biostatistical Methods;Breathing;career development;Cell Proliferation;Cells;Cellular Morphology;Clip;collaborative environment;Communication;Complication;Counseling;Crush Injury;culture plates;Data;Data Analyses;Deglutition;Demyelinations;design;Development;Development Plans;Diameter;Drug Delivery Systems;Dysphonia;Electromyography;Encapsulated;Exhibits;Exposure to;Fibrin;Fibrinogen;Funding;Glycolates;Goals;Grant;Head and Neck Surgeon;Head and Neck Surgery;Hydrogels;Image;Immunohistochemistry;Impairment;Implant;improved;In Vitro;Individual;Inflammation;Injections;injured;Injury;injury recovery;insight;interest;Intervention;Ipsilateral;K-Series Research Career Programs;Knowledge;Laryngeal muscle structure;Laryngoscopy;Larynx;Left;Long-Evans Rats;Measurement;Measures;Mechanics;Melatonin;Melatonin Receptors;Mentors;Mentorship;meter;Methods;mitochondrial dysfunction;Mobility decline;Modeling;Monaco;Monitor;Morphology;Motion;Movement;Nature;Neck;Nerve;nerve injury;Neural Conduction;Neuromuscular Junction;Neurosciences;Operative Surgical Procedures;Otolaryngology;Oxidative Stress;Oxygen Consumption;particle;Patients;Peripheral nerve injury;Peripheral Nerves;Pharmaceutical Preparations;Postoperative Period;preservation;Procedures;Proliferating;Quality of life;Rattus;Recovery;Recovery of Function;Recurrence;Recurrent Laryngeal Nerve;remyelination;Request for Applications;Research;Research Design;response;Risk;scaffold;Schwann Cells;screening;Severities;Site;skills;Spectrophotometry;Speech;Stains;System;Therapeutic;therapeutic evaluation;Thrombin;Thyroidectomy;Time;timeline;tissue culture;Topical application;translational scientist;Trauma;Tuna;Ultrasonography;United States National Institutes of Health;Up-Regulation;Visualization;vocal cord;Voice;Work

PROJECT_TITLE: Prolonged Local Melatonin Delivery for Recurrent Laryngeal Nerve Neuropraxia

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]