NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE Pancreatic cancer is characterized by the expansion of heterogenous cancer-associated fibroblasts (CAFs) that are believed to play tumor-promoting and tumor-restricting roles in disease progression; this heterogeneity is programmed, in part, by the diverse cellular origins of CAFs. Preliminary evidence suggests that mesothelial cells give rise to a phenotypically and functionally distinct class of CAFs in pancreatic cancer. Thus, the goal of this proposal is to investigate the quantitative and qualitative contribution of mesothelial-derived CAFs to the pancreatic tumor microenvironment, and to ascertain their functional role in disease progression.

PI_NAMEs: BISCHOFF, ALLISON  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: advanced disease;cancer cell;Cancer Etiology;Cell Line;Cells;Cessation of life;Characteristics;Coculture Techniques;cytokine;Data;Development;Disease;Disease Progression;experimental study;Fibroblasts;Fibrosis;Flow Cytometry;Genetic Engineering;Genetic Models;Genetic Models for Cancer;Genetic Transcription;Genetically Engineered Mouse;Goals;Heterogeneity;Histopathologic Grade;Human;Immune;immune cell infiltrate;immune function;Immunofluorescence Immunologic;immunoregulation;immunosuppressive macrophages;In Vitro;in vitro Assay;in vivo Model;Infiltration;Injections;Investigation;KRAS oncogenesis;Lesion;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Mediating;Mesothelial Cell;Mesothelium;Migration Assay;Modeling;monolayer;mouse model;Mus;novel;novel strategies;Organ;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pancreatic Intraepithelial Neoplasia;pancreatic neoplasm;Pathogenesis;Patients;Phenotype;Play;Population;Property;restraint;Role;single-cell RNA sequencing;Source;Survival Rate;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapy resistant;Tissues;tool;tumor;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Weights;United States;Western Blotting;WT1 gene

PROJECT_TITLE: The role of mesothelial-derived cancer-associated fibroblasts in the pathogenesis of pancreatic ductal adenocarcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-Z (20)]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN JUAN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PUERTO RICO RIO PIEDRAS

ORG_STATE: PR

PHR: PROJECT NARRATIVE. Radial glia-like cells (RGLC) remain an untapped potential therapy source in response to central nervous system injury. This proposal aims to establish an evolutionary relationship between vertebrate and echinoderm RGLC, increment RGLC marker repertoire, and identify transcription factors providing de-differentiation capacities to the RGLC population. This study will provide a fundamental understanding of this cell population, its subtypes in the regenerating nervous tissue, and the critical gene regulators needed to establish central nervous tissue therapy in adults.

PI_NAMEs: MIRANDA-NEGRON, YAMIL D (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Address;Adult;adult neurogenesis;Affect;Animals;Automobile Driving;Back;Birds;Bromodeoxyuridine;CCRL2 gene;cell dedifferentiation;Cell Physiology;Cell Proliferation;cell type;Cells;Cellular Morphology;Central Nervous System;central nervous system injury;Cerebrum;Characteristics;Chordata;Classification;Collection;Complex;Comprehension;Cytoskeleton;Data;Databases;Development;disability;Echinodermata;Elements;Embryo;Event;experimental study;Fiber;Fishes;Fluorescent in Situ Hybridization;Future;Gene Activation;Gene Expression Profiling;Generations;Genes;Genetic;genetic element;Genetic Markers;Heterogeneity;Holothuria;Hour;Human;improved;In Situ Hybridization;In Vitro;in vivo;Injury;innovation;insight;Invertebrates;knock-down;Knowledge;Label;Mammals;mature animal;Mediating;Mediator;member;Messenger RNA;Methods;Modeling;Molecular;Molecular Analysis;molecular marker;Morphology;Natural regeneration;Nerve;Nerve Regeneration;nerve stem cell;Nerve Tissue;Neurodegenerative Disorders;neurogenesis;neurogenetics;Neuroglia;neuron regeneration;Neurons;Organism;Orthologous Gene;Outcome;Pathway interactions;Pattern;Phylogenetic Analysis;Play;pluripotency;Population;Process;Radial;Reaction;recruit;regeneration potential;regenerative;Regenerative capacity;Regenerative response;Regulator Genes;response;Rodent;Role;Salamander;Sea Cucumbers;Small Interfering RNA;Source;Spinal Cord;stem cell therapy;stem cells;Structure of radial nerve;System;Testing;therapeutic target;tissue regeneration;Tissue Therapy;Tissue-Specific Gene Expression;Tissues;tool;transcription factor;transcriptome;transcriptomics;Validation;Vertebrates;virtual;Zebrafish

PROJECT_TITLE: Molecular analysis of radial glial-like cells and their roles in nervous system regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Nashville

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project narrative In vitro human blood-brain barrier (BBB) models are valuable research tools for studying vascular dysfunction in Alzheimer’s disease and related dementias. However, current models do not capture the full spectrum of BBB properties, which ultimately limits their utility. This proposal will examine if these models can be improved by more faithfully mimicking the signaling events that govern BBB development in vivo.

PI_NAMEs: BRUNGER, JONATHAN MATTHEW;LIPPMANN, ETHAN  (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: 3-Dimensional;Ablation;Acceleration;Address;Adoption;Alzheimer's disease patient;Alzheimer's disease related dementia;Animal Model;Animals;Architecture;Astrocytes;Autocrine Communication;Benchmarking;beta catenin;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Circulation;Blood Vessels;blood-brain barrier function;Brain;brain endothelial cell;brain tissue;cadherin 5;CD31 Antigens;Cell Line;Cell Separation;Cells;Characteristics;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Communities;Complex;CRISPR-mediated transcriptional activation;Cues;Data Set;Defect;Development;differentiation protocol;Disease;Endothelial Cells;endothelial stem cell;Endothelium;Engineering;Ensure;Epithelium;Event;Excision;Exhibits;Future;Genes;Genetic Transcription;Growth Factor;Guide RNA;Health;Hemorrhage;Heterogeneity;Homeostasis;Human;human induced pluripotent stem cells;Image;improved;In Vitro;in vitro Assay;in vivo;in vivo Model;induced pluripotent stem cell;KDR gene;Ligands;Membrane;Modeling;Molecular;Molecular Profiling;neural;neurovascular;notch protein;Operative Surgical Procedures;Organoids;Outcome;overexpression;paracrine;Pathology;Pathway interactions;Pattern;Pericytes;Peripheral;Phenotype;pluripotent stem cell differentiation;Property;Proteins;Protocols documentation;Psychological reinforcement;receptor;Research;Research Personnel;Resected;Signal Transduction;small molecule;Source;Specific qualifier value;synthetic biology;Synthetic Genes;System;tool;trafficking;Transcription Coactivator;transcription factor;transcriptome;transcriptome sequencing;Transgenes;Treatment Factor;two-dimensional;vascular contributions;Vascular Diseases;WNT Signaling Pathway

PROJECT_TITLE: Engineering developmentally-relevant Wnt signaling events to improve iPSC-derived blood-brain barrier models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-M (91)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project Narrative Temperature-dependent, trait-based transmission models are essential to predicting and controlling dengue virus (DENV) transmission by Aedes aegpyti and Aedes albopictus mosquitoes. They are limited, however, due to temperature being the sole abiotic factor considered, despite other widespread abiotic factors, such as insecticides, being well known to impact the parameters of the models. Through experiments crossing common insecticides with temperature treatments, this application will develop and parameterize an insecticide- and temperature-dependent trait-based transmission model for DENV that is expected to predict dengue incidence more accurately than current temperature-alone models, identify the extent to which temperature impacts the efficacy of common insecticides, and determine how to respond to and leverage climate change in the face of range shifts and expansions.

PI_NAMEs: HEFFERNAN, PATRICK  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Adolescent;Adult;Adult women;Aedes;Affect;Bayesian Analysis;Bite;Blood;Cessation of life;Climate;climate change;Culicidae;decamethrin;Dengue;Dengue Virus;Development;Disease;disorder risk;Dose;egg;Equation;Exhibits;experimental study;Exposure to;Family;feeding;Fertility;Flaviviridae;Goals;Human;human disease;Incidence;infection rate;Insecticides;Longevity;Measures;Modeling;mortality;Mosquito-borne infectious disease;Organophosphates;pathogen;Performance;Plaque Assay;Population;Population Growth;Populations at Risk;predictive modeling;Predisposition;Prevalence;Primary Infection;Proxy;pyrethroid;reproductive;response;risk prediction;RNA Viruses;Seasons;Statistical Data Interpretation;Surface;Temephos;Temperature;Testing;Toxic effect;trait;transmission process;viral transmission;virus development;Virus Diseases;Width

PROJECT_TITLE: Impact of insecticide control measures and temperature on Dengue Virus transmission by Aedes aegypti mosquitoes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Rehabilitation

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The proposed ancillary project will evaluate how musculoskeletal biomechanics influences rotator cuff tear symptoms. We will use a combination of experimental and computational methods to examine neuromuscular control and glenohumeral joint health in individuals with symptomatic rotator cuff tears, individuals with asymptomatic rotator cuff tears, and healthy controls (no tears, no pain). Then, through integrated analyses of findings from the ancillary and parent projects, we will elucidate biological mechanisms driving symptoms, thereby aiding identification of rotator cuff phenotypes and treatment targets.

PI_NAMEs: NICHOLS, JENNIFER A. (contact);POZZI, FEDERICO

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Accelerated Executive Review;American;Anatomy;Area;Artificial Intelligence;Automobile Driving;Biological;Biomechanics;Biomedical Engineering;Biometry;Body System;Caring;Cartilage;central sensitization;cohort;Computing Methodologies;Data Science;Degenerative polyarthritis;deltoid muscle;design;Dissociation;Distress;Early identification;Early Intervention;Electromyography;end stage disease;Etiology;Evaluation;exercise intervention;experience;explainable artificial intelligence;Functional disorder;Goals;Head;Health;High Prevalence;Human;imaging study;Individual;Intramuscular;Investigation;joint destruction;Joint structure of shoulder region;Joints;Knowledge;Magnetic Resonance Imaging;Measurement;Measures;Medical;Medical Imaging;Mission;Motion;mouse model;Movement;Muscle;Musculoskeletal;Musculoskeletal System;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;neural;neuroimaging;neuromuscular;neuromuscular examination;Orthopedic Surgery;Outcome;Pain;parent project;Parents;Pathogenesis;Pathologic;Patient-Focused Outcomes;Patients;personalized intervention;personalized medicine;Phenotype;Physical therapy;psychosocial;radiological imaging;Recovery of Function;recruit;Relaxation;Research;Research Methodology;Rotator Cuff;rotator cuff tear;scapula;Severities;Shoulder;simulation;somatosensory;Strategic Planning;Structure;success;Symptoms;System;Tendon structure;Time;trapezius muscle;Visit;Work

PROJECT_TITLE: Biomechanics Contributions to Symptoms and Joint Health in Individuals with Rotator Cuff Tears

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 SP (M2)]


NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences

ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative Neuronal gene expression profiles reflect cellular activity histories. Distinct activity patterns are transduced into specific gene expression programs which encode the properties of the inciting pattern. Here we exploit the simple, precisely controllable, and easily accessible C. elegans nervous system to describe the molecular pathways which orchestrate activity-dependent gene expression via genetic and epigenetic mechanisms.

PI_NAMEs: BATES, SAMUEL GAITHER (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Affect;Afferent Neurons;Animals;antagonist;ATAC-seq;Bioinformatics;Caenorhabditis elegans;Cell model;cell type;Chromatin;Chromatin Structure;Complex;CREB1 gene;Data;Encapsulated;Epigenetic Process;experience;experimental study;Frequencies;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Goals;High temperature of physical object;in vivo;Individual;Kinetics;Link;Mediating;Molecular;Molecular Profiling;mutant;Nervous System;Neurons;Organism;Pathway interactions;Pattern;Physiological;Play;Population;programs;Property;Publishing;Recording of previous events;Regulation;Regulatory Pathway;Reporter;Resolution;response;Role;segregation;Shapes;Sorting;Stimulus;System;Temperature;Training;transcription factor;Transcription Repressor;transcriptome;transcriptome sequencing;Translating;translating ribosome affinity purification and RNA-sequencing;Up-Regulation;Work

PROJECT_TITLE: Regulatory Strategies for the Control of Activity-Dependent Gene Expression in a Single Neuron Type


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Mental Health;Neurodegenerative;Neurosciences;Regenerative Medicine

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: LAY STATEMENT/Narrative Molecular Mechanisms of Neuronal Connectivity September 10 – 14, 2024 The precise wiring, or neuronal connectivity, of the nervous system is the foundation upon which all other aspects of brain function are based. Neuronal wiring is achieved in a series of discrete and modular developmental decisions. First, neurons become ‘polarized’, extending dendrites that receive input from other neurons and a single axon that conveys information to other neurons. Next, ‘axon guidance’ describes the process by which the axon is guided to the correct target, often extending great distances through the developing body and brain. Once in the appropriate target region, the axon forms specialized connections with other neurons, a process that is termed ‘synapse formation’. Finally, neural circuitry is refined through the elaboration or elimination of synaptic connections. Understanding these sequential processes has profound implications for human health. Regeneration of damaged axons and neural circuitry will require a clear understanding of development. Diverse neurological diseases are now being clearly associated with defects in these processes. This conference of international scientists will meet to discuss the latest research in this important field of axon wiring, dendrite formation, synaptogenesis, regeneration and degeneration of neuronal connections.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Anatomy;Area;Axon;axon guidance;axon injury;axon regeneration;Biochemistry;Biological Models;Brain;career;career development;career networking;Cells;Cellular biology;clinically relevant;Collaborations;Communication;Computational Biology;Consultations;Data;Defect;Dendrites;Development;Discipline;Electrophysiology (science);Ensure;Environment;Equilibrium;Faculty;Fostering;Foundations;Functional Imaging;Gender;Genetic;Geographic Locations;Goals;graduate student;Health;Human;human stem cells;Incentives;Industrialization;Industry;insight;interest;International;Interview;Invertebrates;Laboratories;laboratory facility;lectures;Length of Stay;Mediation;meetings;model organism;Molecular;Molecular Biology;Morphogenesis;Natural regeneration;Nerve Degeneration;Nerve Regeneration;Nervous System;Nervous System Disorder;neural;neural circuit;Neuroglia;neuron regeneration;neuronal circuitry;Neuronal Plasticity;Neurons;neurophysiology;Neurosciences;new technology;optical imaging;Oral;Participant;Positioning Attribute;Postdoctoral Fellow;posters;Process;programs;Publishing;repaired;Research;Research Institute;Research Personnel;Schedule;Scientist;Series;structural biology;success;symposium;Synapses;synaptogenesis;System;Thinking;transcriptomics;ultra high resolution;Underrepresented Minority;unpublished works;Work

PROJECT_TITLE: CSHL 2024 Molecular Mechanisms of Neuronal Connectivity Conference

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-K (43)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative  The Neural Mechanisms of Acoustic Communication (NMAC) Gordon Research Conference aims to discuss and debate new findings in communication research and related fields. This meeting fulfills a unique niche through its focus on comparative approaches to the study of neural circuits that mediate interactive acoustic behavior across taxa that represent 800 million years of evolution. This conference aims to create conversations that achieve a unifying understanding of the neural underpinnings of acoustic communication by uncovering broadly relevant algorithms that lay the groundwork for addressing the core neural impairments underlying speech and various social disorders.

PI_NAMEs: SCHMIDT, MARC F (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acceleration;Acoustics;Address;Affect;Algorithms;Animal Model;Apraxia;Behavior;Biological Models;Brain;brain computer interface;Brain region;Broca Aphasia;Callithrix;career;career life balance;Chiroptera;Clinic;clinically relevant;Collaborations;Communication;Communication Research;Communities;comparative;Development;Disease;Environment;Event;Evolution;Faculty;Feeling;fly;Functional disorder;Generations;Goals;graduate student;Heart Diseases;Human;Impairment;improved;Individual;insight;interest;Jordan;Laboratories;Lead;Linguistics;Liquid substance;Maine;Mediating;meetings;Mentorship;Methodology;Mission;Modeling;neural;neural circuit;neuromechanism;Neurophysiology - biologic function;next generation;novel;Occupations;Participant;Postdoctoral Fellow;posters;pre-doctoral;Process;professor;programs;Rana;Research;Research Personnel;Scientist;Secure;segregation;Series;Signal Transduction;Snakes;social;Social Behavior;social deficits;social organization;Songbirds;Speech;Speech Disorders;Stuttering;symposium;System;Techniques;Thinking;Time;tool;Translations;United States National Institutes of Health;unpublished works

PROJECT_TITLE: 2024 Neural Mechanisms of Acoustic Communication Gordon Research Conference and Seminar

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Diabetes;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative Every 6 seconds, a person dies from diabetes. Myocardial infarction-related cardiac arrhythmia is the most common cause of mortality in patients with type 2 diabetes mellitus, however, current therapies such as glucose control failed to reduce myocardial infarction–related high mortality in diabetic patients. This project will introduce a novel therapeutic strategy using optogenetic technique to restore diabetes- impaired cardiac function, and to observe whether this strategy improves myocardial infarction-related cardiac arrhythmia and high mortality in animals with type 2 diabetes mellitus, which will provide potential clinical therapeutics for improving prognosis and reducing the mortality in patients with diabetes.

PI_NAMEs: ZHANG, DONGZE  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Acetylcholine;Acute myocardial infarction;Adrenergic Fibers;Animals;Anti-Arrhythmia Agents;Arrhythmia;bench to bedside;blood glucose regulation;Cardiac;Cell Physiology;cell type;Cells;Cervical;Choline O-Acetyltransferase;cholinergic;cholinergic neuron;Clinical;Conscious;Data;Dependovirus;design;Development;Diabetes Mellitus;diabetic;diabetic patient;Diameter;Disease;Electric Stimulation;external ear auricle;Future;Ganglia;Genes;Genetic;glycemic control;Grant;Heart;Heart Atrium;heart function;Impairment;Implant;improved;improved outcome;in vivo;Infection;Inferior vena cava structure;Intervention;Investigation;Left;Left atrial structure;Light;light emission;Link;Location;Lung;miniaturize;mortality;Myocardial Infarction;Nerve;neuronal circuitry;neuronal excitability;Neurons;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Opsin;optogenetics;Organ Specificity;Patients;Persons;pharmacologic;Population;Prognosis;promoter;Quality of life;Rattus;Regulation;Reporting;restoration;Right atrial structure;Secure;Serious Adverse Event;side effect;Specificity;Speed;sudden cardiac death;Superior vena cava structure;Techniques;Testing;Therapeutic;Time;timeline;Transfection;United States National Institutes of Health;Veins;Vena caval structure;Ventricular;Ventricular Arrhythmia;Ventricular Function;wireless;Withdrawal

PROJECT_TITLE: Optogenetic modulation of cardiac vagal function improves prognosis in diabetes

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: AG

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: In the United States, Alzheimer’s disease (AD) is the leading cause of dementia, and the 5th leading cause of death, in older adults. Advancements in the measurement of biomarkers, including the build-up of amyloid-beta and neurofibrillary tau tangles, as well as the extent of neuronal injury, can improve the diagnosis and classification of AD. This study will investigate the potential for ultra-high sensitivity and resolution functional positron emission tomography (fPET) to detect changes in neuronal activity that underly AD and AD- related dementias (ADRD), setting the groundwork for future studies evaluating small changes in metabolism and tau that may permit early detection of AD and distinction from other dementias.

PI_NAMEs: KHATTAR, NIKKITA  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta deposition;Address;Air;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-Protein;Biological Markers;biomarker development;blood oxygen level dependent;Brain;Brain region;Cannulas;Caring;Cause of Death;Cell Nucleus;Classification;Clinical;Cognitive;cognitive task;Continuous Infusion;Dedications;Dementia;design;Diagnosis;Disease;Disease Progression;Early Diagnosis;entorhinal cortex;Functional Magnetic Resonance Imaging;Future;Glucose;glucose metabolism;Goals;Goggles;Head;Human;human subject;hyperphosphorylated tau;imaging system;Impaired cognition;improved;in vivo;Induced Neurons;Infusion procedures;Lateral Geniculate Body;Lewy Body Dementia;Measurement;Measures;Medical;Mentorship;Metabolic;Metabolism;metabolomics;Motion;multidisciplinary;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;Neuronal Injury;neuronal metabolism;Neurons;Nose;novel;Odors;older adult;Olfactory dysfunction;Olfactory Pathways;Parkinson Disease;Participant;Pathogenesis;patient stratification;Pattern;Performance;Photic Stimulation;Physicians;piriform cortex;Positron-Emission Tomography;Protocols documentation;Research;research study;Resolution;Rest;Scientist;Senile Plaques;Signal Transduction;skills;specific biomarkers;standard measure;Structure;synucleinopathy;System;tau aggregation;tau Proteins;Techniques;Tissues;tomography;Tracer;Training;ultra high resolution;United States;Visual Cortex

PROJECT_TITLE: Assessing activation in the human brain using ultra-high performance FDG functional PET to investigate neurodegenerative disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Genetics;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: Chicago

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative Challenges using language in social contexts, such as conversational interactions, impacts autistic individuals across the spectrum and throughout the lifespan. Efforts to understand the causes of these challenges have primarily focused on speakers of English, leaving unanswered critical questions about how social language use might be impacted differently for autistic individuals who speak other languages. This project addresses this question by studying social language abilities and related neural and behavioral markers in autism across speakers of English and Cantonese in order to identify clinically and biologically important traits among these diverse language groups.

PI_NAMEs: LOSH, MOLLY C (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Acoustics;Address;adult with autism spectrum disorder;analytical tool;Auditory;autism spectrum disorder;autism symptoms;autistic children;Behavioral;biobank;Biological;brain behavior;case control;Clinical;clinical care;clinically significant;Complex;Computational Linguistics;Data;Data Collection;data harmonization;data reduction;Data Science;data sharing;design;Development;differential expression;Dimensions;experience;family genetics;Family Study;First Degree Relative;Genes;Genetic;Genetic Markers;Genetic Predisposition to Disease;Genetic study;Grain;improved;individuals with autism spectrum disorder;innovation;insight;International;Intervention;Investigation;Language;language processing;large language model;life span;Light;Linguistics;Link;Machine Learning;Measures;Methods;Modeling;Molecular Genetics;Motor Skills;multidisciplinary;Multilingualism;Natural Language Processing;neural;neurophysiology;novel;Participant;Periodicity;Phenotype;Process;Protocols documentation;Psycholinguistics;Research;Research Design;Research Personnel;Sampling;Semantics;skills;social;Social Environment;Societies;Speech;Statistical Models;Structure;Subgroup;supervised learning;trait;Transcend;Translating;Translations;unsupervised learning;Validation;Work

PROJECT_TITLE: A cross-linguistic, family-genetic study of language in autism and the broad autism phenotype

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Prevention;Vaccine Related

ORG_CITY: Princeton

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Public health narrative: We still do not understand why certain pathogens, such as hepatitis C virus (HCV), can only naturally infect humans and chimpanzees. This project will improve our understanding of how responses by host cells determine the course of infection. Our data will be critical for generating improved animal models to study HCV and other viruses that infect primarily humans.

PI_NAMEs: PIETSCHMANN, THOMAS ;PLOSS, ALEXANDER  (contact);SCHWARTZ, ROBERT E

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Affinity;Animal Model;Anti-viral Agents;Binding;Biological;cancer risk;Cells;Cessation of life;Chronic Hepatitis C;chronic infection;Cirrhosis;co-infection;Coin;Communicable Diseases;comorbidity;Complex;Coupled;Data;Dependence;Development;Diabetes Mellitus;end stage liver disease;Engineering;Environment;experience;gain of function;Germany;Hepatitis C;Hepatitis C Transmission;Hepatitis C Vaccine;Hepatitis C virus;Hepatitis C-Like Viruses;Hepatocyte;high risk;HIV;Human;humanized mouse;Imaging Techniques;Immune;Immune response;Immunocompetent;Impairment;improved;In Vitro;in vivo;Inbreeding;Individual;Infection;Integration Host Factors;Knock-in Mouse;Knock-out;Liver diseases;liver injury;Malignant neoplasm of liver;Mass Spectrum Analysis;Modeling;Molecular;mouse model;Mus;Mutation;Natural Killer Cells;Nonstructural Protein;Obesity;Pan Genus;pathogen;Patients;Persons;Phenotype;Physiological;Positioning Attribute;Predisposition;prevent;Primary carcinoma of the liver cells;Productivity;Public Health;Publishing;replicase;Reporting;Research;RNA;RNA replication;Seminal;Shapes;Signal Transduction;single-cell RNA sequencing;STAT1 gene;Testing;therapeutic vaccine;Tissues;Transgenic Mice;Transgenic Organisms;transmission process;Treatment Cost;Tropism;vaccine candidate;vaccine development;vaccine trial;Vaccines;Variant;Viral;Viral Pathogenesis;Virus;Virus Diseases;virus genetics;Virus Replication;Work

PROJECT_TITLE: Genetic Viral and Host Adaptations to Breach Species Barriers of HCV

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE This proposal will investigate how TcdB, a virulence factor produced from the hypervirulent C. difficile strain takes advantage of a cell surface proteoglycan to promote disease severity. Furthermore, the results of the proposed experiments will yield potential targets for the development of antibiotic alternative therapeutics to mitigate severe C. difficile infections.

PI_NAMEs: DOYLE, DENA ANNIE (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Adherence;Anaerobic Bacteria;angiogenesis;Antibiotic Therapy;antibiotic-associated diarrhea;Antibiotics;Behavioral;Binding;Biochemical;Biological Assay;Blood Vessels;Cell Adhesion;cell behavior;Cell membrane;cell motility;Cell surface;Cell Surface Receptors;Cells;Cessation of life;Chondroitin Sulfate A;Chondroitin Sulfate Proteoglycan;Chondroitin Sulfates;Cleaved cell;clinically relevant;Clostridium difficile;Colon;Complex;cytotoxicity;Development;Diarrhea;Disease;Divalent Cations;dysbiosis;Endothelium;Epidemic;Event;Exhibits;Exotoxins;experimental study;Exposure to;Extracellular Matrix;Genetic Transcription;Glucosyltransferase;Glycosaminoglycans;Goals;gut microbiome;Hospitalization;Immune;Infection;Inflammatory Bowel Diseases;Injury;insight;Integral Membrane Protein;Integrins;Intoxication;Investigation;Laminin;Matrix Metalloproteinases;Mediating;migration;Modeling;Myofibroblast;Pathology;Patients;Penetration;Peptides;Pericytes;Predisposition;prevent;Production;Proliferating;Proteoglycan;Proton Pump Inhibitors;Pseudomembranous Colitis;receptor;receptor binding;Reproduction spores;Research Training;RNA;Role;screening;Severity of illness;Signal Transduction;Signaling Molecule;Site-Directed Mutagenesis;superresolution microscopy;Surface;Symptoms;Therapeutic;Tissues;Toxin;Transportation;Tropism;uptake;Virulence Factors;wound healing

PROJECT_TITLE: Toxin B receptor mediated events in Clostridioides difficile disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


NIH_SPENDING_CATS: Aging;Microbiome;Physical Activity

ORG_CITY: LEXINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Skeletal muscle atrophy caused by inactivity/disuse affects young and old individuals alike; however, the full recovery of muscle mass and function is compromised in the elderly. The purpose of this proposal is to determine if substances made by the gut microbiome are able to prevent muscle atrophy during limb immobilization and enhance the recovery of muscle size and strength after disuse.

PI_NAMEs: BURKE, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Accidents;Affect;Age;age group;age related;Aging;aging population;Area;Atrophic;Attenuated;attenuation;Award;Bioinformatics;candidate identification;Clinical;Communication;Data;Development;Discipline;Disease;disease prognosis;Disuse Atrophy;drug candidate;effectiveness evaluation;Elderly;Exercise;exercise training;experience;Experimental Designs;experimental study;Faculty;Fellowship;Flexor;functional decline;Gait;Goals;Growth;gut microbiome;Health;Hindlimb;Hindlimb Suspension;Hospitalization;Immobilization;Immunohistochemistry;Impairment;Injury;Limb structure;Link;Literature;Maintenance;Mass Spectrum Analysis;Measurement;Measures;member;Mentorship;metabolomics;microbial;Microbiology;microbiome therapeutics;Microscopy;Modeling;Mus;Muscle;muscle form;Muscle function;muscle strength;Muscular Atrophy;novel therapeutics;old mice;older adult;Older Population;Oral;Outcome;Pathway interactions;Patients;Pharmacologic Substance;Population;Postdoctoral Fellow;Predisposition;preservation;prevent;protective effect;Quality of life;Recovery;Regulation;Rehabilitation therapy;Research;Risk;Role;sedentary;Skeletal Muscle;skeletal muscle wasting;skeletal preservation;skills;Succinates;System;tenure track;Testing;Therapeutic Intervention;Training;Universities;Western Blotting;Work;Writing

PROJECT_TITLE: Using the gut microbiome to treat disuse atrophy in aging.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


NIH_SPENDING_CATS: Genetics;Microbiome

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Currently, much of the genetic systems of Akkermansia muciniphila remain unknown, despite the growing interest surrounding the use of this microbe in therapeutics. By utilizing newly developed genetic tools, combined with several in vitro assays, this proposal will elucidate the genetic mechanisms that underlie mucin degradation, the fundamental host-bacterial interaction that this commensal microbe undertakes. The knowledge gained from this study will enhance the knowledge of A. muciniphila and shed light onto the causes of its many purported effects.

PI_NAMEs: SHARMA, AGASTYA  (contact)

PROJECT_TERMS: Bacteria;Bacteroides thetaiotaomicron;Bar Codes;Binding;Binding Proteins;Biological;Biological Assay;Biology;Carbon;Carrier Proteins;Cells;Cellular Structures;Characteristics;commensal microbes;Complex;Consumption;Crohn's disease;Dedications;Degradation Pathway;Diabetes Mellitus;DNA;Environment;Epitopes;experimental study;extracellular;Flow Cytometry;Fluorescein;Fluorescence;Fluorescence-Activated Cell Sorting;gastrointestinal;Gastrointestinal tract structure;Gene Cluster;Genes;Genetic;Genetic Determinism;genomic locus;Glutamates;Glycoproteins;Glycoside Hydrolases;Gram-Negative Bacteria;Growth;gut inflammation;gut microbes;gut microbiome;gut microbiota;Health;Health Benefit;Human;Hydrolase;Image Cytometry;immune health;in vitro Assay;in vivo;interest;Intestines;Knowledge;Label;Libraries;Light;Mediating;Membrane;Membrane Proteins;Metabolic;Metabolic Diseases;Metabolism;Microbe;Modality;Molecular;Mucins;Mucous body substance;Mus;Mutagenesis;mutant;Mutation;Nitrogen;novel;Obesity;Organelles;periplasm;Polysaccharides;Population;population based;Probiotics;Process;Proline;protein function;protein purification;protein structure;Proteins;Proteomics;Role;Sorting;Source;Structure;Surface;System;Therapeutic;tool;transposon sequencing;Ulcerative Colitis;uptake;Work

PROJECT_TITLE: Investigating the Mucin Utilization Capabilities of Akkermansia muciniphila


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Hematology;Immunotherapy;Women's Health Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Clonal Hematopoiesis of Indeterminate Potential (CHIP), a common clinical entity in which people without clinical hematologic abnormalities have somatic leukemia-associated mutations in their blood and bone marrow, is increasingly being recognized as a dysregulated inflammatory process that is more prevalent among patients with solid tumors. Interrogating the interplay between CHIP and solid tumors via murine models and ex vivo experiments, using triple negative breast cancer as a model system, will enhance understanding of the tumor immune microenvironment and define potential new therapeutic targets and management strategies. Harnessing large clinical biobanks and prospectively collected clinical specimens will further provide translational insight into the use of CHIP as a prognostic biomarker for patients with solid tumors.

PI_NAMEs: REED, SARAH CAMILLE (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Address;Affect;Age;Behavior;biobank;Biological Assay;Biological Models;Blood;Bone Marrow;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;Cancer Biology;Cardiovascular Diseases;cardiovascular disorder risk;carrier status;Cell Communication;Cell model;Cells;Cellular Assay;Chemotherapy and/or radiation;Clinical;Clinical Management;clinical sequencing;Clinical Trials;Coculture Techniques;cohort;Complex;Computer Analysis;COVID-19;cytokine;Data;Disease;ERBB2 gene;Estrogen receptor negative;Estrogen Receptors;experimental study;Exposure to;Fellowship;Flow Cytometry;Funding;Future;Gene Expression;Gene Expression Profiling;General Population;Genes;Genotoxic Stress;Growth;Hematologic Neoplasms;Hematology;Hematopoiesis;Hematopoietic;histopathological examination;Histopathology;Immune;immune cell infiltrate;Immune signaling;Immunophenotyping;Immunotherapy;improved;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Infiltrate;insight;Knowledge;leukemia;Lymphocyte;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Modeling;molecular sequence database;monocyte;mortality;mouse model;Mus;Mutation;Myelogenous;Myeloid Cells;neoplastic cell;new therapeutic target;novel;novel therapeutic intervention;Osteoporosis;Outcome;Pathway interactions;patient biomarkers;Patients;Persons;Physicians;Plasma;Population;pressure;Process;Production;Progesterone Receptors;Prognosis;prognostic;prognostic indicator;Prognostic Marker;programs;prospective;PTPRC gene;recruit;Research;Resistance;Risk;Sampling;Scientist;Signal Transduction;small cell lung carcinoma;Solid;Solid Neoplasm;Somatic Mutation;Specimen;standard care;Study models;Techniques;Testing;Tissues;Training;Translational Research;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Biology;tumor growth;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumor-immune system interactions;Up-Regulation;Work

PROJECT_TITLE: Impact of Clonal Hematopoiesis of Indeterminate Potential (CHIP) on tumor microenvironment and clinical outcomes in triple negative breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (20)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Contraception/Reproduction;Infant Mortality;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_DEPT: PHARMACOLOGY

PHR: Public Health Relevance Currently used drugs to inhibit uterine contractions (i.e. “tocolytics”) and manage spontaneous preterm labor (sPL) are limited by their effectiveness and pose significant fetal and maternal adverse effects due to their lack of uterine-selectivity. The proposed research will optimize a uterine-targeted drug delivery system (DDS) and determine its in vivo efficacy and side effect mitigation of current tocolytics. These studies will provide vital groundbreaking information for use of nanomedicine to safely manage sPL for longer term therapy than currently allowed.

PI_NAMEs: HANSEN, CHRISTOPHER JOSEPH (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Achievement;Acids;Address;Adverse effects;Antibodies;antibody conjugate;Benchmarking;Biocompatible Materials;biodegradable polymer;Birth Rate;Blood Chemical Analysis;Blood Pressure;Chemicals;Chemistry;Circulation;Clinical;Communication;controlled release;Data;delayed birth;Delayed-Action Preparations;design;Development;Diameter;Discipline of obstetrics;Dose;Drug Delivery Systems;drug efficacy;Drug Targeting;Drug usage;Effectiveness;efficacy testing;Encapsulated;Environment;fabrication;Faculty;Fellowship;fetal;Food and Drug Administration Drug Approval;Formulation;Fostering;Future;Goals;Grant;Immunoglobulin G;improved;In Vitro;in vivo;Indomethacin;Infant Mortality;interest;Kinetics;Leadership;Learning;Left;Live Birth;Maleimides;Manuscripts;Medical;member;Mentors;Methods;Mifepristone;Modeling;Modification;mouse model;Mus;myometrium;nano;nanomedicine;neonatal morbidity;Neonatal Mortality;Nifedipine;novel;off-label use;Oxytocin;Oxytocin Receptor;particle;Pharmaceutical Preparations;Physiology;Placenta;Polymers;pre-clinical;Pregnancy;premature;Premature Birth;Premature Labor;primary outcome;Property;public health relevance;Reproducibility;Research;Research Institute;Resources;Respiration;Series;side effect;skills;Smooth Muscle Myocytes;Solvents;Specificity;surfactant;System;Terbutaline;Testing;Therapeutic;therapeutic evaluation;Time Management;Tocolysis;Tocolytic Agents;Training;Uterine Contraction;Uterus;Vascular Smooth Muscle

PROJECT_TITLE: Development of a novel tocolytic delivery system to treat preterm labor

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F06-L (20)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Diarrheal disease caused by the parasite Cryptosporidium causes significant death and disability mainly in young children and immune compromised adults. This single-celled parasite takes up residence in and manipulates cells of the intestine to extract nutrients and avoid destruction by the immune system. Our work will reveal the molecular machines used by Cryptosporidium to accomplish these feats, which will help to identify suitable targets for the development of life-saving vaccines and treatments for this disease.

PI_NAMEs: COHEN, ALLISON  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: 3-Dimensional;Adult;Age;Amino Acids;Amino Sugars;Architecture;asexual;Binding;Biogenesis;Biological Assay;Biology;Cell membrane;Cell Nucleus;Cells;Cessation of life;Child;combat;Complement;Complex;Coupled;Cryo-electron tomography;Cryoelectron Microscopy;cryogenics;Cryptosporidiosis;Cryptosporidium;Cryptosporidium parvum;Cytoplasm;Cytoplasmic Granules;Cytosol;Data;Detection;Development;diarrheal disease;disability;Disease;effective therapy;Electron Microscopy;Electrons;Endocytosis;Engineering;Epitopes;Face;Fluorescence;Fluorescence Microscopy;Genes;genetic manipulation;Glucose Transporter;Hour;Image;Imaging Techniques;Immune;Immune Evasion;Immune mediated destruction;Immune system;Immunofluorescence Immunologic;In Situ;Infection;innovation;insight;Intestines;intracellular parasitism;Invaded;Ions;Label;Life;light microscopy;Mediating;Membrane;Microscopy;Molecular;Molecular Machines;Nutrient;Optics;Organelles;Orthologous Gene;Parasites;Parasitology;Plasmodium;protein complex;Proteins;rational design;Reporter;residence;Resolution;Role;Scanning Electron Microscopy;Shapes;Signal Transduction;small molecule;solute;Structure;Testing;Therapeutic;Thinness;three-dimensional visualization;Tight Junctions;Tomogram;Toxoplasma;Toxoplasma gondii;Transmission Electron Microscopy;Vaccines;Vacuole;Work

PROJECT_TITLE: Interrogating the molecular architecture of the Cryptosporidium host-parasite interface


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Approved medications and available treatments for opioid use disorder (OUD) do not adequately address persistent symptoms that can lead to relapse; thus, we desperately need to identify new molecular targets for medication development. In this proposal, we will identify targets expressed by a specific subtype of neuron within prefrontal cortex that has been implicated and regulating motivated and affective behaviors. We will use a combination of transcriptomics, electrophysiology, pharmacology, and genetic engineering to define how candidate targets regulate brain function and opioid use behaviors.

PI_NAMEs: JOFFE, MAX E (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Abstinence;Acute;Address;Adverse effects;Affective;Agonist;Attenuated;Behavior;Behavioral;Brain;Cell Adhesion Molecules;Cell Physiology;cell type;Cellular biology;combat;craving;Development;druggable target;dysphoria;Electrophysiology (science);experience;fentanyl self-administration;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;gastrointestinal;Gene Expression;Genetic Engineering;Goals;Growth Factor;Hormones;Individual;inhibitory neuron;Inpatients;Interneurons;medication for opioid use disorder;Membrane;Molecular Target;Moods;Motivation;Neurons;Neurotransmitters;Opioid;Opioid Receptor;opioid use;opioid use disorder;opioid withdrawal;persistent symptom;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physiology;Prefrontal Cortex;progenitor;Property;Proteins;Public Health;receptor;Rehabilitation therapy;Relapse;remediation;risk minimization;selective expression;Signal Pathway;Signal Transduction;Somatostatin;Synaptic plasticity;Techniques;tool;Transcript;transcriptomics;Translations;transmission process;Withdrawal Symptom

PROJECT_TITLE: DEVELOPING GPCR MODULATORS OF SOMATOSTATIN INTERNEURONS FOR THE TREATMENT OF OPIOID USE DISORDER

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 MXS-M (M1)]


NIH_SPENDING_CATS: Infant Mortality;Lung;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Sleep Research;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Sudden Infant Death Syndrome

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Sudden infant death syndrome (SIDS) is an idiopathic disease in which subtle brainstem defects in the serotonergic system have been observed. The goal of this proposal is to understand the mechanistic role of serotonin receptors in both 1) the neonate auto-resuscitation reflex and 2) how the loss of it can alter the neuronal activity dynamics and 3) control serotonergic neurogenesis. Findings will inform key processes thought to be disrupted in many SIDS cases and yield critical insights for the development of future therapeutics and diagnostics.

PI_NAMEs: PATEL, DIPAK  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Acute;Affect;Affinity;Age Years;Anoxia;Apnea;Arousal;Autopsy;Autoreceptors;Binding;Binding Sites;Biological Assay;Bradycardia;Brain Stem;Breathing;case finding;Cause of Death;cell type;Cells;Cessation of life;Child;Cre driver;Data;database query;Defect;Development;Diagnostic;Disease;Distress;Embryo;Enzymes;Etiology;Exposure to;Face;Failure;falls;Feedback;Functional disorder;Future;Gene Expression;Genes;Genetic;Goals;Head;Heart;Hypoxia;in vivo;Infant;Infant Mortality;insight;Investigation;Knockout Mice;Lifting;Link;loss of function;Mediating;Mediator;Medical;Medical History;Modeling;Molecular;Mus;mutant;Mutant Strains Mice;Neonatal;Neonatal Mortality;neonate;nerve stem cell;neurogenesis;neuron development;Neurons;novel;Outcome;Oxygen;Play;Population;Positioning Attribute;postnatal;postsynaptic;precursor cell;presynaptic;Presynaptic Receptors;Process;Production;Prone Position;Proteins;Proxy;public database;receptor;receptor function;Reflex action;Reporter;Research;Research Personnel;Respiration;respiratory;response;Risk;Robotics;Role;Series;Serotonergic System;Serotonin;serotonin receptor;Serotonin Receptor 5-HT1B;Signal Transduction;Site;Sleep;stressor;Sudden infant death syndrome;System;Testing;Therapeutic;tool;TPH2;transcriptomics;Work

PROJECT_TITLE: The role of the Htr1B serotonin receptor in the neonate autoresuscitation reflex and embryonic serotonergic neurogenesis as a potential mechanism in Sudden Infant Death Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Precision Medicine;Prevention;Psoriasis

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE Psoriatic arthritis (PsA) is a chronic, immune-mediate inflammatory disease characterized by widespread skin and musculoskeletal inflammation affecting 1% of the world’s population (including ~1.5 million adults in the US alone). While the use of biologic therapies (including TNF and IL-17 blockers) has significantly improved the lives of many people with PsA, over 50% of patients do not respond adequately to these drugs. Successful completion of our proposed studies will provide key insights into digital and molecular markers that affect TNF/IL-17 blockade and the implications for prediction of clinical response, ultimately identifying patients likely to improve (or to benefit from alternative medications) even before the treatments are prescribed.

PI_NAMEs: SCHER, JOSE U. (contact);THEBERGE, ASHLEIGH BROOKS

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Adult;Affect;Aftercare;Arthritis;Articular Range of Motion;Autoimmune Diseases;Autoimmunity;Biological;Biological Markers;Biological Products;Biological Response Modifier Therapy;Blood;Blood specimen;Cellular Phone;Chronic;Clinical;Clinical Data;clinical decision-making;clinical efficacy;clinical phenotype;clinical practice;clinical predictors;Complex;computerized tools;cytokine;Data;Data Set;Decision Making;Deformity;Development;Diagnosis;digital;Digital biomarker;digital data;digital tool;Dimensions;Direct Costs;Disease;Disease Progression;Disease remission;disorder prevention;Early Diagnosis;Early identification;Early treatment;Enrollment;Exposure to;FDA approved;Gait;Gene Expression;Gene Expression Profiling;Genes;Genetic Transcription;Goals;Health;Health Expenditures;Home;IL17 gene;Immune;immunoregulation;improved;improved outcome;Individual;Individual Differences;individual patient;individual response;Inflammation;Inflammatory;Inflammatory Arthritis;inhibitor;innovation;insight;inter-individual variation;Interleukin-12;interleukin-23;joint destruction;joint inflammation;joint injury;Joints;Left;Longitudinal Studies;machine learning method;Measurement;Mediating;Methods;Molecular;molecular marker;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Musculoskeletal;novel;open source;Outcome;Pathogenesis;Pathologic;patient response;Patient-Focused Outcomes;Patients;Peripheral;personalized approach;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Population;precision medicine;Prediction of Response to Therapy;Predictive Value;Predisposition;prevent;Proteins;Psoriasis;Psoriatic Arthritis;Publishing;Quality of life;Rationalization;remote assessment;response;rheumatologist;Rheumatology;RNA;Sampling;Signal Transduction;Skin;small molecule;Synovitis;Therapeutic;therapy outcome;Time;TNF gene;Transcript;transcriptome;transcriptomics;treatment response

PROJECT_TITLE: Precision Monitoring of Treatment Response in Early Psoriatic Arthritis: Integrating at-Home RNA Microsampling into Ongoing, Remote, Smart Phone-Based, Digital Data Capturing


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_DEPT: GENETICS

PHR: Tuberculosis granulomas are have been studied for over 150 years, the bacterial factors involved in this immune structure are relatively understudied. Using the zebrafish- Mycobacteirum marinum model to recapitulate this important aspect of tuberculosis disease, this proposed research will elucidate how a bacterial factor, SigE, is important for both bacterial survival and modulation of host immunity in mycobacterial granulomas. Identifying and determining the bacterial factors that allow mycobacteria to persist in the granuloma can unveil potential drug targets and therapies to treat tuberculosis infection.

PI_NAMEs: MENON, ARUNA RAJENDRAN (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Acute;Adult;Affect;anti-microbial peptide;Bacteria;Cause of Death;cell envelope;Cells;Cessation of life;Characteristics;combat;cytokine;Data;Defect;Disease;Drug Targeting;E-Cadherin;Elements;Epithelial Cells;Fishes;Future;Genes;Genus Mycobacterium;Glycolipids;Granuloma;Growth;Host Defense Mechanism;Hypoxia;Immune;Immune response;Immune system;Immunity;Infection;Infectious Agent;Inflammation;Inflammatory;Interleukin-1 beta;knock-down;Knowledge;Label;Larva;Link;Lipids;Macrophage;Maintenance;Mediating;Modeling;Modification;Morphology;mutant;mycobacterial;Mycobacterium marinum;Mycobacterium tuberculosis;novel;pathogen;pathogen exposure;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenocopy;Phenotype;Process;Protein Secretion;Proteins;receptor;Regulon;Research;Resolution;response;restraint;Role;sensor;Sigma Factor;stressor;Structure;Surface;Techniques;Therapeutic;Time;TNF gene;Transgenic Organisms;Tuberculosis;tuberculosis granuloma;tuberculosis treatment;Zebrafish

PROJECT_TITLE: The Sigma factor SigE's role in mycobacterial granulomas


ORG_CITY: CAMBRIDGE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative Bacteriophages contribute a large portion of the global genetic diversity and yet are largely understudied for their diversity and evolutionary contributions. A better understanding of the interactions these varied phages have with bacteria in the environment will allow for more detailed ecological experiments as well as inform new therapeutics. This project develops a novel assay with broad applications for targeted discovery of environmental phages based on receptor proteins of interest which vastly increases the speed of such discoveries and allows the user to focus in on a chosen system with ease.

PI_NAMEs: RAND, ELEANOR  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Adoption;alternative treatment;antibiotic efflux;Antibiotic Resistance;Antibiotic susceptibility;Antibiotics;Appearance;Bacteria;Bacteriophages;Biological Assay;Biological Models;Case Study;Cells;Clinical;clinical application;Clinical Trials;clinically relevant;Coculture Techniques;collaborative environment;Complement;Computer Analysis;Dependence;design;Ecosystem;efflux pump;Environment;Escherichia coli;Evolution;experimental study;Future;Genetic;Genetic Recombination;Genetic Variation;Goals;Gram-Negative Bacteria;guided inquiry;improved;Individual;Infection;interest;Knock-out;knockout gene;Knowledge;Membrane;Membrane Proteins;Methods;Modeling;mutant;Mutation;novel;novel therapeutics;pathogen;pathogenic bacteria;Phage Receptors;Plaque Assay;prevent;Proteins;Protocols documentation;Pseudomonas aeruginosa;Public Health;rapid technique;receptor;Resistance;resistance factors;Sampling;screening;Signal Transduction;Speed;System;Techniques;Testing;Therapeutic;Virulence;Virulence Factors;Visual;Work

PROJECT_TITLE: Receptor-Guided Discovery of Environmental Phages


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative Neuronal mRNA dysregulation is associated with neurodevelopmental diseases and axon defects, yet the roles and mechanisms of mRNA regulation in presynaptic assembly remain poorly understood. This project takes advantage of the genetic accessibility and transparency of the nematode C. elegans to investigate mRNA regulation as synaptogenesis occurs in the living animal, focusing on the conserved essential presynaptic active zone gene syd-2/liprin-alpha. Studying mRNA regulation in vivo using complementary high-resolution live imaging and unbiased biochemical approaches will identify both the precise biological roles these processes play in synaptic function and identify novel regulators for future therapeutic targeting.

PI_NAMEs: ROGOW, JACKSON A (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Achievement;Adult;Animals;autism spectrum disorder;Axon;Binding Sites;Biochemical;Biological;Biotin;Biotinylation;brain tissue;Caenorhabditis elegans;career;Cell Nucleus;cell type;Cells;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;college;Complex;connectome;Cytoplasm;Cytoplasmic Granules;Data;Defect;Detection;Development;Developmental Delay Disorders;educational atmosphere;Enzymes;Epilepsy;Event;experimental study;Fluorescence Recovery After Photobleaching;FMR1 gene;Fostering;Fragile X Syndrome;Future;Gene Expression Profile;Genes;Genetic;genetic information;genetic regulatory protein;Genetic Transcription;Goals;Growth;high resolution imaging;Homologous Gene;Human;human disease;Image;image translation;imaging system;Imaging technology;in vivo;Intellectual functioning disability;Label;Laboratories;Life Cycle Stages;Maintenance;Mammals;Maps;Mass Spectrum Analysis;Measures;Medicine;Mentorship;Messenger RNA;Movement;MS2 coat protein;mutant;Mutation;Nematoda;Nervous System Disorder;neural;neurodevelopment;Neurodevelopmental Disorder;Neurologic Symptoms;neuron component;Neurons;novel;operation;Organism;Patients;Peptide Signal Sequences;Phenotype;Physicians;Physiology;Play;postsynaptic;posttranscriptional;presynaptic;Process;Protein Family;protein protein interaction;Proteins;Proteomics;recruit;Regulation;repaired;Resolution;response;RNA;RNA-Binding Proteins;RNA-Protein Interaction;Role;scaffold;Scientist;Shapes;Signal Transduction;Synapses;synaptic function;synaptogenesis;synergism;System;therapeutic target;Time;trafficking;Transcript;Transcriptional Regulation;transcriptomics;Translations;Type 2 Spinocerebellar Ataxia;Variant;Work

PROJECT_TITLE: Regulation of Presynaptic Gene Transcripts During Synaptogenesis


NIH_SPENDING_CATS: Cancer

ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

ORG_STATE: MD

PHR: Project Narrative Small GTPases are molecular switches that control numerous signaling networks involved in tumor growth and are therefore of great interest to cancer biologists seeking to develop novel therapies. Given that 93% of attendees from the 2022 meeting indicated that they would attend this conference again, we propose the continuation of this highly successful scientific conference that has been held every two years since 1991 and has served as a critical platform to advance the scientific field.

PI_NAMEs: O'BRYAN, JOHN P (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Achievement;Adhesions;Area;Award;Binding;Binding Proteins;Biochemical;Biology;career;career development;Cell division;Cell Division Process;cell growth;cell motility;Cell Nucleus;Cell Physiology;Cells;cellular targeting;Clinic;Coin;Collaborations;Communication;Communities;Cytoskeleton;Development;Disease;Drug Design;drug development;Drug Targeting;Educational workshop;Environment;Environment Design;falls;Family;FDA approved;Financial Support;Fostering;Funding;Future;G-Protein-Coupled Receptors;Gene Expression;Goals;Growth Factor Receptors;GTP Binding;GTP-Binding Proteins;guanine nucleotide binding protein;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Heterotrimeric GTP-Binding Proteins;Hormones;Human;human disease;Human Genome;Industry;infancy;interest;Investments;lectures;Life;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;meetings;member;Metabolism;Mission;Molecular;Monomeric GTP-Binding Proteins;Motility;Mutate;new therapeutic target;novel therapeutics;Nuclear Import;Oncogenic;Oncoproteins;Phagocytosis;Pharmaceutical Preparations;pharmacologic;Play;posters;preference;programs;Protein Export Pathway;Protein Family;protein function;Proteins;ran GTP-Binding Protein;Ras Inhibitor;rational design;receptor;Recording of previous events;recruit;Regulation;Relaxation;Research;rho;Role;Science;Scientific Advances and Accomplishments;Scientist;Seminal;Senior Scientist;Services;Signal Pathway;Signal Transduction;summer research;symposium;Technology;Therapeutic;Time;Training;Transducers;Transistors;Travel;tumor;tumor growth;tumorigenesis;Underrepresented Minority;Underrepresented Populations;vesicle transport;virtual;Woman;Work

PROJECT_TITLE: The Regulation and Function of Small GTPases

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (J1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Alzheimer’s disease (AD) is a leading cause of death and an increasingly urgent health concern, as it afflicts a growing percentage of the elderly population, with observed disparities across racial and educational demographics. Objective, accurate, and reliable diagnosis of AD remains a severe unmet need, as existing diagnoses involve either lengthy and subjective clinical tests with brain scans or expensive and invasive procedures like spinal taps. To address this challenge, the proposed research aims to develop an ultrasensitive, cost-effective, and minimally invasive diagnostic tool for accurately measuring a panel of novel and robust AD protein biomarkers in blood, to inform effective intervention.

PI_NAMEs: ZHANG, STEPHANIE J. (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: accurate diagnosis;Address;Alzheimer's Disease;Alzheimer's disease blood test;Alzheimer's disease diagnosis;Alzheimer's disease diagnostic;Alzheimer's disease test;Alzheimer’s disease biomarker;American;Amyloid beta-42;Analytical Chemistry;Antibodies;Binding;Biological Assay;Biological Markers;biomarker panel;Biotin;Biotinylation;Blood;Blood - brain barrier anatomy;Blood Tests;Brain;brain cell;Brain scan;career;Cause of Death;cell type;Cells;Cerebrospinal Fluid;Chemicals;Clinical;clinical infrastructure;Clinical Sensitivity;collaborative environment;Consumption;cost;cost effective;demographics;design;Detection;detection limit;Development;Diagnosis;Diagnostic;diagnostic biomarker;diagnostic development;diagnostic tool;digital;Disease Outcome;Disease Progression;Disparity;DNA;drug efficacy;Education;Educational workshop;effective intervention;effective therapy;Elderly;Engineering;Enzyme-Linked Immunosorbent Assay;Equipment;extracellular vesicles;flexibility;Grant;Health;Hospitals;Immunoassay;Impaired cognition;improved;Individual;infection risk;inorganic phosphate;Interleukin-1 beta;Intervention;Label;Laboratories;Lipids;machine learning algorithm;magnetic beads;Magnetism;Measurement;Measures;Memory impairment;Methods;minimally invasive;Molecular;mortality;Neurodegenerative Disorders;neuroimaging;neuroinflammation;Neurologic;Noise;novel;novel therapeutics;Onset of illness;Parents;Pathologic;Peptide Hydrolases;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Plasma;Population;predictive modeling;predictive test;presymptomatic testing;Procedures;protein biomarkers;Proteins;Protocols documentation;Race;Reagent;Research;Sampling;Screening procedure;Severities;single molecule;skills;Source;specific biomarkers;Spinal Puncture;Spinal Tap;symposium;Symptoms;System;tau aggregation;tau Proteins;tau-1;Techniques;Technology;technology development;Temperature;Testing;Time;TNF gene;tool;Training;Translations;treatment stratification;Woman;Work;Writing

PROJECT_TITLE: Development of an Ultrasensitive Blood-based Diagnostic for Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Public Health Relevance One of the fundamental questions in neuroscience is how activity of brain cells represents stimuli in the environment. The proposed research program seeks to define fundamental aspects of how olfactory stimuli are processed by the olfactory bulb, the primary olfactory brain region. Since olfaction is often impaired early in the course of neurodegenerative diseases, our work may lead to new insights into the core circuit functions affected in these conditions.

PI_NAMEs: STROWBRIDGE, BEN W (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Acceleration;Acute;Address;Affect;Alzheimer's Disease;Apical;autism spectrum disorder;Axon;Brain;brain cell;Brain region;Cell Physiology;cell type;Cells;Chlorides;Code;Complex;Dendrites;Discrimination;Disease;Distal;Electrophysiology (science);Elements;Environment;Equilibrium;Excitatory Postsynaptic Potentials;experimental study;Functional disorder;gamma-Aminobutyric Acid;Goals;granule cell;Imaging Techniques;Impairment;insight;Interneurons;Logic;Mediating;Methods;mitral cell;Modality;Molecular;Nervous System Disorder;Neurodegenerative Disorders;Neurons;Neurosciences;novel;Odors;olfactory bulb;Olfactory Pathways;olfactory stimulus;optical imaging;Optics;Output;Parkinson Disease;Pathway interactions;Pattern;Phase;Photometry;Pilot Projects;Play;Population;postsynaptic;presynaptic;Process;programs;public health relevance;Publishing;Pyramidal Cells;receptor;Receptor Cell;Research;response;Rodent;Role;Schizophrenia;Sensory;sensory input;sensory stimulus;Site;Slice;Smell Perception;Specificity;Stimulus;Stream;Synapses;System;two-photon;Work

PROJECT_TITLE: local circuits in the olfactory bulb

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative: The proposed project will leverage and enhance the sponsor’s community-engaged study, NoCHeS, examining sleep health among Mexican Americans at the US/Mexico border, characterizing relationships between sleep and cardiometabolic disease risk, and investigating the role of social-environmental factors including acculturation, stress, socioeconomics, and health behaviors in sleep. The proposed project will expand this analysis by assessing the role of ACEs and IT in CVH, determining the relationship between ACEs/IT and social- environmental factors, and evaluating the role of proposed risk factors in the relationship between ACEs/IT and CVH among adults of Mexican descent living at the US-Mexico border. The findings from this study will advance understanding of the impact of ACEs/IT on CVH and sleep and provide foundation for future research examining mechanisms between traumas, sleep and CVH.

PI_NAMEs: RASMUSSEN, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Accelerometer;Acculturation;Address;Adult;adverse childhood events;American Heart Association;Anxiety Disorders;Behavioral;Blood Glucose;blood lipid;Blood Pressure;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Childhood;Cholesterol;Clinic Visits;Collection;Communities;community engaged approach;community engaged research;Data;Diabetes Mellitus;diaries;Diet;Diet Records;Dimensions;disorder risk;Disparity;economic behavior;Environmental Risk Factor;executive function;Exposure to;Foundations;Funding;Future;General Population;Glycosylated hemoglobin A;Health;Health behavior;health disparity;high risk;Hispanic;Hispanic ancestry;Hispanic Populations;Home;improved;intergenerational;Intervention;Life;Link;Literature;Measures;Mediating;Mental Depression;Mental Health;Mexican;Mexican Americans;Mexico;model building;modifiable risk;National Institute on Minority Health and Health Disparities;Neurocognitive;Neurocognitive Deficit;nicotine exposure;novel;Obesity;Outcome;Pathway interactions;Patient Self-Report;Physical activity;Physiological;Population;Postdoctoral Fellow;Premature Mortality;Prevalence;Prevention strategy;processing speed;programs;Protocols documentation;Psychosocial Stress;public health relevance;Questionnaires;recruit;Reduce health disparities;Research;Risk;Risk Factors;Role;Short-Term Memory;Sleep;Sleep Disorders;sleep health;Smoking History;social;Social Behavior;social health determinants;Social support;socioeconomic disadvantage;socioeconomics;Spanish/English;Stress;Substance abuse problem;suicidal risk;Surveys;therapy development;Training;Translational Research;Trauma;United States National Institutes of Health;Victimization;vigilance;Work

PROJECT_TITLE: Pathways linking childhood and intergenerational trauma at the US-Mexico border with cardiovascular health.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: IOWA CITY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Cognitive deficits in schizophrenia and bipolar disorder are associated with altered activity in the cerebellum. The goal of our project is to discover the mechanisms underlying cerebellar contributions to cognition. The findings of our project could form the foundation for translational research into how alterations in cerebellar communication with the frontal cortex relates to cognitive symptoms in schizophrenia and bipolar disorder.

PI_NAMEs: FREEMAN, JOHN H (contact);PARKER, KRYSTAL LYNN

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Affect;Animals;Area;Attention;Auditory;Back;Basic Science;Behavior;Behavioral;behavioral response;Bipolar Disorder;Bypass;Cell Nucleus;Cerebellar Cortex;Cerebellar Nuclei;Cerebellum;Cognition;Cognitive deficits;cognitive function;cognitive process;cognitive task;Communication;Conditioned Stimulus;Cues;Development;Disease;Electrophysiology (science);eyeblink conditioning;Foundations;frontal lobe;Functional disorder;Goals;Human;Impaired cognition;Impairment;innovation;Knowledge;Lateral;Learning;Light;Medial;Mental disorders;mossy fiber;motor learning;neural;neural circuit;Neurobehavioral Manifestations;neuromechanism;Neurons;neurophysiology;new therapeutic target;optogenetics;Output;Pathway interactions;Performance;Play;Pontine structure;pre-clinical research;Procedures;Prosencephalon;Ramp;Rattus;Reaction Time;Research;Research Project Grants;Rodent;Role;Schizophrenia;segregation;Sensory;sensory input;Short-Term Memory;Signal Transduction;Source;Specificity;System;Testing;Thalamic structure;Time;time interval;time use;Translational Research;Visual

PROJECT_TITLE: Roles of Descending Forebrain Pathways to the Cerebellum in Behavioral Timing

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The expanding make-on-demand molecular libraries have enabled the discovery of new chemotypes through a technique called structure-based docking, paving the road to novel therapeutics. However, the libraries have grown so large that current methods can't handle them efficiently. To address this, a new approach is proposed that accelerates the discovery of potent molecules in the expanding chemical space.

PI_NAMEs: MAILHOT, OLIVIER  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: 3-Dimensional;Acceleration;addiction;Address;Affinity;Algorithms;beta-Lactamase;Biological Assay;Biological Models;Chemicals;Collection;Communities;Computer software;COVID-19;Crystallization;Data;Dependence;Descriptor;Docking;DRD4 gene;early screening;Ensure;expectation;experimental study;Fellowship;Fingerprint;in vivo;Lead;Learning;Libraries;Ligand Binding;Ligands;Machine Learning;machine learning method;machine learning model;Mental Depression;Methodology;Methods;Modeling;Molecular;Molecular Bank;Molecular Conformation;novel;novel strategies;novel therapeutics;Pain;Performance;receptor;Resources;screening;simulation;skills;small molecule libraries;space travel;Structure;Techniques;Testing;Training;training data;virtual screening;Visit;X-Ray Crystallography

PROJECT_TITLE: Rational prioritization algorithm for docking-based virtual screening of trillion-scale make-on-demand small molecule libraries

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE Human cytomegalovirus (HCMV) is the leading cause of congenital birth defects worldwide, yet no vaccine exists, and treatment options remain ineffective or toxic to immunocompromised and pregnant individuals. Neutralizing antibodies targeting specific viral surface proteins, such as glycoprotein B (gB), could be used for safe and effective passive immunization. This application proposes to characterize the structure of the engineered gB variant and its interaction with new and existing neutralizing antibodies with the goal of identifying an immunogen that can be used for generation of robust and protective neutralizing antibodies for therapeutic intervention.

PI_NAMEs: MCCLAVE, MARIA KRASILNIKOV (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Adopted;Antibodies;Antigens;antiviral immunity;Binding;Biological Assay;career;Cell fusion;Cell membrane;Cells;CMV glycoprotein B;Complex;Congenital Abnormality;Cryoelectron Microscopy;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Vaccines;Data;Development;ds-DNA;Effectiveness;Engineering;Ensure;Epitope Mapping;Epitopes;Europe;Future;Generations;Glycoproteins;Goals;Herpesviridae;Human;humanized mouse;Immune Evasion;Immune response;Immunocompromised Host;immunogenic;Individual;innovation;latent infection;Maps;Mediating;Membrane;Membrane Proteins;Memory B-Lymphocyte;Molecular Conformation;Monoclonal Antibodies;Negative Staining;neutralizing antibody;Passive Immunization;pathogen;Population;pregnant;preservation;Property;Reagent;Research Personnel;Resolution;Respiratory syncytial virus;response;Risk;Sampling;Scientist;seropositive;skills;small molecule;Specificity;stem;Structure;success;Surface;Therapeutic;therapeutic development;Therapeutic Intervention;Training;vaccine candidate;Vaccines;Variant;Viral;Virus;Virus Diseases;Work

PROJECT_TITLE: Structural and antigenic characterization of human cytomegalovirus gB

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Nutrition;Obesity

PHR: Project Narrative Prolonged hypoxia in mice and humans dramatically transforms systemic metabolism, decreasing body weight, fat mass, and blood glucose levels. Oxygen deprivation itself is not a realistic therapeutic option, but hypoxia- induced metabolic improvements coincide with significant reprogramming of branched-chain amino acid metabolism in adipose tissue, presenting a potential target for treating obesity. This project will investigate the mechanism underlying this rewiring of BCAA metabolism in adipose tissue and the role of this rewiring in controlling adiposity and glucose clearance during hypoxia.

PI_NAMEs: MIDHA, AYUSH  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Adipocytes;Adipose tissue;Affect;Altitude;amino acid metabolism;Automobile Driving;Biochemical;Blood Glucose;blood glucose regulation;Body Weight;Body Weight decreased;Branched-Chain Amino Acids;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;career;Catabolism;cell growth regulation;Cell Respiration;Chronic;Communities;Complex;Data;deprivation;effective therapy;Electron Transport;Electrons;Electrophoresis;Enzymes;epidemiologic data;Equilibrium;Exhibits;experimental study;Exposure to;Fatty acid glycerol esters;Foundations;Glucose;glucose uptake;Health;Human;Human Genetics;Hydroxy Acids;Hypoxia;Impairment;improved;in vitro Model;Insulin Resistance;Knockout Mice;Label;lactate dehydrogenase A;Link;Measures;Metabolic;Metabolic Control;Metabolic Diseases;Metabolic Pathway;metabolic phenotype;metabolic profile;Metabolism;Modeling;mortality;mouse model;Multienzyme Complexes;Mus;NADH;Natural regeneration;Non-Insulin-Dependent Diabetes Mellitus;normoxia;novel strategies;novel therapeutic intervention;Obesity;obesity treatment;oxidation;Oxygen;Oxygen Consumption;Pathology;Pathway interactions;Phenotype;Physicians;Physiology;Play;Population;Positron-Emission Tomography;Production;Regulation;Roentgen Rays;Role;Scientist;Testing;Textbooks;Therapeutic;Valine;Western Blotting;Wild Type Mouse;Work

PROJECT_TITLE: Investigating the role of BCAA metabolism in regulating adiposity during systemic hypoxia.

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Diabetes Endocrinology and Metabolic Diseases [DDK-E]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Lung;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The experiments in this proposal will explore molecular mechanisms involved in the transition from endothelial barrier dysfunction, the pathophysiological hallmark of acute respiratory distress syndrome (ARDS), to endothelial barrier recovery. In particular, we will explore how protein-protein interactions featuring MK2, caspase 3 and YAP mediate changes in endothelial cell apoptosis that contribute to endothelial barrier dysfunction during development of ARDS and that can be targeted to accelerate recovery.

PI_NAMEs: DAMARLA, MAHENDRA  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acceleration;Acute Respiratory Distress Syndrome;angiogenesis;Apoptosis;Apoptotic;Binding;Blood Vessels;CASP3 gene;Caspase;Cell Death;cell motility;Cell Nucleus;Cell Proliferation;Complex;Cytoplasm;Cytoskeleton;Cytosol;Data;Development;Edema;Endothelial Cells;endothelial stem cell;Endothelium;Endotoxins;Enzymes;experimental study;Functional disorder;Future;Hypoxia;In Vitro;in vivo;Incidence;Inflammation Mediators;Injury;insight;Intercellular Junctions;Laboratories;Location;Lung;lung development;lung injury;Mechanics;Mediating;migration;Mitogen-Activated Protein Kinases;Molecular;mortality;Mus;novel;Nuclear;Nuclear Translocation;Pathogenesis;Pathogenicity;Phase;Phosphotransferases;Play;prevent;Prevention;Process;Proliferating;Property;protective effect;Protein Kinase;protein protein interaction;Proteins;Recovery;Regulation;Resolution;response;restoration;Role;Severities;Signal Transduction;Signaling Molecule;Signaling Protein;Stimulus;Stress;Testing;therapeutic target;Tissues;TLR4 gene;Transgenic Mice;Tumor Necrosis Factor Ligand Superfamily Member 6;Vascular Permeabilities;Work

PROJECT_TITLE: Targeting Divergent Roles of Caspase 3 to Promote Endothelial Barrier Recovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-H (03)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Eye Disease and Disorders of Vision;Neurosciences;Sleep Research

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE/RELEVANCE  Mammalian rod, cone, and melanopsin photoreceptors contribute to image-forming visual processes that encode complex computations in the retina and cortex. Vision also influences behaviors like sleep, which result in feedback mechanisms that enable sleep as a neuromodulator to the cortical neural code. Understanding how multiplexed photoreceptor systems and sleep modulate cortical computations driven by complex visual stimuli could lead to the development of more sophisticated computational models that help improve the design of cortical prostheses.

PI_NAMEs: AU, DAVID  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Affect;area striata;Automobile Driving;Behavior;behavior influence;Behavioral Assay;Blindness;Brain;circadian;Code;Collaborations;Color;Communication;comparative;Complex;Computer Analysis;Computer Models;Cone;Data;design;Development;Discrimination;Disease;Educational workshop;Electrophysiology (science);Environment;Event;Evolution;experience;experimental study;Feedback;Fellowship;ganglion cell;Goals;graduate student;Grant;Image;improved;improvement on sleep;In Vitro;in vivo;insight;Light;luminance;Manuscripts;Measurement;Measures;Mediating;melanopsin;Mentorship;Microscopy;Mus;neural;Neuromodulator;neuronal excitability;Neurons;neuroregulation;Neurosciences;Noise;Pathway interactions;Pattern;Photoreceptors;Phototransduction;predictive modeling;Process;Prosthesis;Pupil light reflex;Research;Resources;response;Retina;Retinal Cone;Retinal Ganglion Cells;Rod;Running;Scientist;Sensory;sight restoration;Signal Transduction;skills;skills training;Sleep;sleep behavior;Sleep Deprivation;Stimulus;symposium;Synapses;Synaptic plasticity;System;Technical Expertise;Time;Training;transmission process;undergraduate student;Vertebrate Photoreceptors;Vision;Vision Disorders;Visual;Visual Cortex;visual information;visual neuroscience;visual processing;visual stimulus;Visual System;Work;Writing

PROJECT_TITLE: The effects of sleep and iPRGCs on computations in the early visual system

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative Systemic infections, like Toxoplasma gondii, result in the contraction of regulatory T cells (Tregs) across host tissues that is associated with the emergence of the effector response along with immunopathological consequences. The aim of this proposal is to understand the consequences of the collapse on the Treg compartment and the mechanisms that contribute to re-population given that my preliminary data suggests there is a phenotypic shift in the re- bounding Treg population following acute infection. Information gleamed from this research will further our understanding of Treg population dynamics throughout the course of infection and provide insight into cytokine networks that may be targeted to manipulate Treg cells and impact pathology.

PI_NAMEs: LANZAR, ZACHARY R (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: acute infection;Address;Affect;Antibodies;Antiparasitic Agents;Binding;Biological Assay;Cell Compartmentation;Cells;Cellular biology;Chronic;chronic infection;Combined Modality Therapy;cytokine;Cytokine Network Pathway;Data;Data Correlations;Data Set;Drug usage;Exhibits;experience;experimental study;Flow Cytometry;Genetic;Heterogeneity;Homeostasis;IL7 gene;Immune Tolerance;In Vitro;in vivo;Infection;Inflammation;insight;interest;Interleukin-10;Interleukin-2;Lead;Literature;Lymphoid;Maintenance;Mediating;Modeling;multiple omics;Mus;Outcome;Output;Parasites;Pathology;Pathway interactions;Phase;Phenotype;Population;Population Control;Population Dynamics;Process;Production;Regulatory T-Lymphocyte;Reporting;Research;response;restoration;secondary lymphoid organ;Shapes;Site;Sorting;Source;Structure;Supplementation;Suppressor-Effector T-Lymphocytes;Survivors;Systemic infection;T cell receptor repertoire sequencing;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;Therapeutic;Thymus Gland;Tissues;Toxoplasma gondii;transcriptome sequencing

PROJECT_TITLE: Impact of Toxoplasma gondii on Treg homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Fibromyalgia;Neurosciences;Pain Research;Precision Medicine

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Fibromyalgia is a debilitating chronic pain condition; although pain is persistent, the severity typically varies across time, making it difficult to effectively manage. Despite this, intra-individual pain variability is rarely studied in fibromyalgia, even though pain variability has been associated with a host of negative outcomes in chronic pain conditions more broadly. This project will apply and develop advanced methodologies within pain research to characterize pain variability in fibromyalgia patients to predict clinically relevant outcomes and ultimately construct individualized pain profiles that can be used in a precision medicine context to target fibromyalgia treatments more effectively.

PI_NAMEs: WHITAKER, MIRINDA MAR (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Activities of Daily Living;affective disturbance;Agreement;American;Area;Arthritis;behavioral phenotyping;Biological Markers;career;central sensitization;Chronic;chronic pain patient;chronic painful condition;chronic widespread pain;Clinical;clinical pain;clinical predictors;Clinical Trials;clinically relevant;comorbidity;comparison control;coping;cost;Data;Ecological momentary assessment;Emotional;Emotions;Equation;experience;Fatigue;Fellowship;Fibromyalgia;fibromyalgia pain;fibromyalgia patients;Functional disorder;Funding;Goals;Health;Healthcare;Heterogeneity;Hour;Hyperalgesia;Impaired cognition;improved;indexing;Individual;individual variation;Institution;interest;Link;Location;Measurement;Measures;Mental Depression;Metformin;Methodology;Modeling;Mood Disorders;Moods;multilevel analysis;Musculoskeletal;Musculoskeletal Pain;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;negative affect;Noise;novel;Outcome;Output;Pain;Pain Disorder;pain model;pain patient;pain processing;Pain Research;pain signal;Patients;Placebos;precision medicine;Prediction of Response to Therapy;Process;Productivity;Quality of life;Regulation;Reporting;Research;Research Design;Research Personnel;response;Running;Severities;Short-Term Memory;skin disorder;Sleeplessness;Statistical Models;Stimulus;Strategic Planning;Stress;Symptoms;System;Testing;Time;tool;Training;Treatment outcome;treatment response;Work

PROJECT_TITLE: Modeling pain variability in fibromyalgia


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Synaptic plasticity changes in a region of the brain called the nucleus accumbens underlie the formation of substance use disorders. This proposal will investigate how angiotensin-converting enzyme inhibition, which modulates endogenous opioid signaling, affects synaptic plasticity within specific neural inputs to the nucleus accumbens. This study will further our understanding of the specific cells and neural circuits that will respond to angiotensin-converting enzyme inhibition, which has potential therapeutic applications for the treatment of substance use disorders.

PI_NAMEs: SWANSON, JESSICA  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: addiction;Addictive Behavior;Affect;Affinity;Agonist;American;Angiotensin-Converting Enzyme Inhibitors;Attenuated;Basal Ganglia;Behavior;Brain;Brain region;career;cell type;Cells;conditional knockout;Corpus striatum structure;Dependence;Development;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;Dorsal;effective therapy;Electric Stimulation;Electrophysiology (science);endogenous opioids;Enkephalins;Enzyme Inhibition;Enzyme Tests;Exhibits;experimental study;extracellular;Fentanyl;Foundations;Future;Genetic;Glutamates;Goals;Impaired health;Individual;Inhibitory Synapse;Interneurons;Label;Laboratories;Long-Term Depression;Measures;Methionine Enkephalin;Molecular;Molecular Target;Mus;neural;neural circuit;Neurons;Neuropeptides;Neurosciences;novel;novel therapeutic intervention;Nucleus Accumbens;Opiate Addiction;Opioid Peptide;Opioid Receptor;opioid use disorder;Opsin;Optics;optogenetics;Output;patch clamp;Peptidyl-Dipeptidase A;Personal Satisfaction;pharmacologic;Phenotype;Play;postsynaptic;preference;presynaptic;Prevention;receptor;Receptor Activation;Regulation;Research;Rewards;Role;selective expression;Signal Transduction;skill acquisition;Source;Structure;Substance Use Disorder;substance use treatment;Synapses;Synaptic plasticity;Synaptic Transmission;Testing;Thalamic structure;Therapeutic;therapeutic target;Training;Transgenic Mice;Viral

PROJECT_TITLE: Input-specific synaptic plasticity in the nucleus accumbens evoked by inhibition of angiotensin-converting enzyme

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ORG_CITY: DALLAS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Properly coordinated cell movement, or migration, is required for healthy tissue development; however, we lack a complete understanding of how molecular players in adhesion are regulated to coordinate migration. Here, I identify a novel tether linking the endoplasmic reticulum (ER) to actin, CLMN, and present evidence that it is required for proper cell migration; I propose that CLMN-mediated ER-actin tethering regulates local targeting of calcium signaling at cell adhesions between the actin cytoskeleton and extracellular matrix, ultimately governing cell migration. By understanding how ER-actin interactions impact migration, we will inform mechanisms of tissue development regulation that are upended in developmental disorders, immune-signaling, and during cancer cell metastasis.

PI_NAMEs: MERTA, HOLLY  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Actins;Adhesions;Automobile Driving;Binding;Binding Proteins;Biochemical;Biological Assay;Biology;Biosensor;Calcium;Calcium Signaling;calponin;cancer cell;career;Cell Adhesion;cell motility;Cell Physiology;Cells;Collaborations;Confocal Microscopy;Cytoskeleton;Data;Defect;Development;developmental disease;Disease;Embryonic Development;Endoplasmic Reticulum;Event;Exhibits;Extracellular Matrix;F-Actin;Family;Fellowship;Focal Adhesions;Image;Immune signaling;innovation;insight;Institution;knock-down;Knowledge;Label;Link;live cell imaging;Maps;Mediating;Membrane;Mentors;Mesenchymal;Microscopy;Microtubules;migration;Molecular;Molecular Biology;Motility;Motion;Movement;mutant;Neoplasm Metastasis;novel;open wound;Organelles;overexpression;Peripheral;Positioning Attribute;Principal Investigator;Process;Productivity;protein complex;Proteins;recruit;Regulation;repaired;Research;Research Personnel;Resolution;Role;RTN4 gene;Signal Transduction;skills;spatiotemporal;Stress Fibers;Techniques;Testing;Tissues;Training;Transmembrane Domain;Work;wound healing

PROJECT_TITLE: Role of ER-to-actin tethering in cell migration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Recombinant adeno-associated virus (rAAV) is a popular DNA vector for gene therapies, but both under- and over-expression of rAAV transgenes can hinder therapeutic benefit. Our group has recently developed a technology that can chemically control gene expression through reversible epigenetic editing. The proposed work will apply this chemical epigenetic technology to rAAV with the goal of improving the safety and efficacy of future gene therapies.

PI_NAMEs: WASSERMAN, SARA ROSE (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Adopted;Affect;Biological Assay;Capsid;Cell Culture Techniques;Cell Nucleus;Cells;Chemicals;Chimeric Proteins;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical Trials;Development;DNA;DNA Binding Domain;DNA cassette;DNA delivery;DNA-Binding Proteins;Dose;Enhancers;Epigenetic Process;Episome;experimental study;FDA approved;Foundations;Future;Gene Expression;Gene Expression Regulation;gene therapy;Gene Transduction Agent;Genes;genomic locus;Genomics;Goals;Human Cell Line;improved;interest;knock-down;Laboratories;Lead;Ligand Binding Domain;Luciferases;Mediating;Methods;Modeling;Modification;nanomolar;next generation;novel;overexpression;Pathway interactions;Plasmids;Process;promoter;Recombinant adeno-associated virus (rAAV);recruit;Regulation;Safety;Site;small molecule;System;Technology;Testing;Therapeutic;Time;tool;Transfection;transgene expression;Transgenes;vector;viral DNA;Viral Genome;Viral Vector;Work

PROJECT_TITLE: Dose control of recombinant Adeno-associated virus with Chemical Epigenetic Modifiers


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Climate-Related Exposures and Conditions

ORG_CITY: NEW HAVEN

ORG_DEPT: CHEMISTRY

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative  The enzymatic reduction of CO2 and oxidation of CO takes place at the C-cluster active site of Carbon Monoxide Dehydrogenases, but the structure and mechanism of the C-cluster have been disputed. In this work, we propose to synthesize smaller models of the C-cluster with systematic differences in composition, which will help us to understand the structure–function relationships within the active site. These active site mimics will be reacted with CO2 and CO and studied using bioinorganic spectroscopy, giving us key insights into the electronic structure and mechanism of CODH.

PI_NAMEs: STONEBRAKER, SAMUEL NEWMAN (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TITLE: Biomimetic Reactivity and Spectroscopy of Carbon Monoxide Dehydrogenase C-Clusters


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cystic Fibrosis;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Secondary infection of Influenza A virus with Streptococcus pneumoniae causes substantial morbidity and mortality worldwide, particularly during influenza pandemic years. The proposed research will investigate the role of influenza-induced endoplasmic reticulum stress in damage to the airway epithelium and increased susceptibility to S. pneumoniae. Findings from this study will provide critical information needed to understand the potential of this interface as a target for host-directed therapeutics aimed at reducing lung injury and the development of secondary bacterial infections after influenza infection.

PI_NAMEs: EARNHARDT, ERIN YEPSEN (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: airway epithelium;airway surface liquid;Avian Influenza;Bacterial Infections;biological adaptation to stress;bronchial epithelium;California;Cell Culture System;Cells;Complex;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Development;endoplasmic reticulum stress;Epithelial Cells;Etiology;Frequencies;Functional disorder;Genetic;Host Defense;Host Defense Mechanism;Human;Immune response;Immunohistochemistry;Infection;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;influenza infection;influenza virus strain;Invaded;Lung;lung injury;Measures;Mediating;Morbidity - disease rate;mortality;Mutate;novel;Optical Coherence Tomography;pandemic disease;pandemic influenza;pandemic virus;pathogen;pathogenic bacteria;Pathogenicity;pharmacologic;Pneumococcal Infections;Predisposition;Production;Property;Protein Secretion;Proteins;Proteome;Proteomics;Publishing;Research;Risk;Role;secondary infection;Secondary to;Streptococcus pneumoniae;stress reduction;Testing;Therapeutic;therapeutic target;trafficking;translational model;Virus Diseases;Virus Replication;Western Blotting;Work

PROJECT_TITLE: Influenza Mediated ER Stress and Secondary Bacterial Infections