NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Dopamine is well-known for its importance in motivating, performing and reinforcing behavior, and its dysfunction is implicated in many neuropsychiatric diseases including depression, addiction and Parkinson’s Disease. How dopamine influences the activity of target neurons to modify behavior, however, remains unclear. Developing an understanding of dopamine’s actions on synapses, cells and circuits will help to clarify these actions and pave the way for novel targets for treatments that leverage these mechanisms.

PI_NAMEs: SIPPY, TANYA  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: addiction;Address;Affect;Arousal;Aversive Stimulus;awake;Behavior;Behavior Therapy;Behavioral;Brain;Calcium;cell type;Cells;Chronic;Closure by clamp;Corpus striatum structure;Cues;Data;Detection;Dopamine;Dopamine Receptor;dopaminergic neuron;Electrophysiology (science);Excitatory Postsynaptic Potentials;Excitatory Synapse;experimental study;extracellular;Functional disorder;Future;Goals;Image;Impairment;In Vitro;in vivo;in vivo calcium imaging;insight;Knowledge;Light;Link;Mammals;Measures;Membrane;Membrane Potentials;Mental Depression;Mental disorders;Methods;Midbrain structure;Molecular Target;Monitor;Mood Disorders;motivated behavior;Motivation;Movement;Mus;Nervous System Disorder;neural;Neurologic;Neuromodulator;Neurons;neuropsychiatric disorder;neuroregulation;novel;novel therapeutic intervention;Obsessive-Compulsive Disorder;optogenetics;Output;Parkinson Disease;Pathway interactions;pharmacologic;Phase;phase change;Physiological;Population;Population Dynamics;Property;Psychotic Disorders;Publishing;reinforced behavior;Reporting;response;Rewards;Role;Sensory;Signal Transduction;Stimulus;Synapses;Synaptic plasticity;Techniques;Testing;Time;Translating;two photon microscopy;Work

PROJECT_TITLE: Dissecting the Synaptic and Cellular Actions of Dopamine in Vivo

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Rare Diseases

ORG_CITY: BERKELEY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The ability of cells to define, change shape depends on their ability to mechanically tense their surroundings through actomyosin-based stress fibers (SFs). In this proposal we combine single-cell tools, traditional cell and molecular biological approaches, and tissue-mimetic culture platforms to investigate how individual SFs with a cell contribute to tension and motility relevant to brain cancer.

PI_NAMEs: KUMAR, SANJAY  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TITLE: Biophysical Control of Cell Form and Function by Single Actomyosin Stress Fibers

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Nutrition

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project narrative There is a need for scientists who appreciate the clinical challenges of patients with digestive diseases and then seek to understand the mechanisms of disease. This research training program will provide a high-quality mentored training experience in basic, translational or clinical research. The fellows trained in this program will be prepared for meaningful careers in research that will ultimately lead to new diagnostic tests and therapies for patients with digestive diseases.

PI_NAMEs: LIDDLE, RODGER A.;MUIR, ANDREW J. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TITLE: Duke Training Grant in Digestive Diseases and Nutrition


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: NARRATIVE Tissues in our bodies accumulate mutations over time. We do not yet understand what the effects of these mutations are on aging and disease. Currently, we do not have good tools to study these mutations in the native context of where cells live, tissues. Here, we will develop new tools to study mutations in tissues, and in particular, assay how and if somatic variants occur in spatial groupings across different types of tissues. After discovering these spatial groupings, we will explore how the variants change the state of the cells that harbor them.

PI_NAMEs: BUENROSTRO, JASON DANIEL;CHEN, FEI  (contact);GETZ, GAD A

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: adverse outcome;Aging;ATAC-seq;Bar Codes;Benchmarking;Biological Assay;cell type;Cells;Clonal Expansion;Computer software;computerized tools;Cues;Data;data quality;Data Set;Disease;DNA;DNA sequencing;Ensure;epigenome;epigenomics;Epithelium;Equipment;fitness;Functional disorder;functional outcomes;Gene Expression;Gene Frequency;Genes;Genetic;genetic variant;Genomics;Goals;Grouping;human tissue;improved;Individual;insight;interest;Measurement;Measures;member;Methods;migration;Modality;Morphology;Mosaicism;multiple omics;Mutation;Neighborhoods;novel;Process;Protocols documentation;Publications;Research;Resolution;Sampling;Slide;software development;Software Tools;Somatic Mutation;stem cell differentiation;stem cell expansion;Technology;technology platform;Technology Transfer;Time;Tissues;tool;transcriptome;transcriptome sequencing;Variant;variant detection;Work

PROJECT_TITLE: A Platform for Scalable Spatial Somatic Variant Profiling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-K(70)R]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE We will answer key clinical questions about the optimal strategies for prostate cancer prevention, detection, and treatment by applying innovative analytic methods to complex longitudinal data. This research will result in the development, application, and dissemination of powerful methods for big clinical data that accelerate progress in cancer research and care.

PI_NAMEs: DICKERMAN, BARBRA ANNE (contact)

PROGRAM_OFFICER_NAME: SARMA, ELIZABETH ANNE

PROJECT_TERMS: Acceleration;analytical method;analytical tool;anti-cancer research;Area;Award;Big Data;cancer care;Cancer Control;cancer prevention;career;career development;Classification;Clinical;clinical care;Clinical Data;clinical decision-making;Communities;comorbidity;Comparative Effectiveness Research;Complex;Computer software;cost effective;Data;Data Science;Databases;design;Detection;Development;dietary;Disease;Documentation;Electronic Health Record;Environment;Epidemiology;Future;Genetic;Genetic Predisposition to Disease;Goals;Health;improved;Indolent;Inherited;innovation;interest;Intervention;Lead;Learning;learning strategy;Life Style;Link;longitudinal database;Machine Learning;Malignant neoplasm of prostate;Malignant Neoplasms;men;Mentors;Methods;multidisciplinary;Nonmetastatic;novel;open source;Patients;personalized medicine;Persons;Phase;Positioning Attribute;prevent;Prevention;programs;Prospective, cohort study;prostate cancer prevention;PSA screening;randomized trial;Recommendation;Recording of previous events;Research;Research Personnel;screening;Screening Result;Shapes;Specific qualifier value;Statistical Methods;Time;tool;Training;Treatment-related toxicity;trial design;tumor;user-friendly;Work

PROJECT_TITLE: Identifying optimal dynamic strategies for prostate cancer control

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: FARMINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Discrimination between distinct salient locations among constellations of similar sensory cues is a crucial function of episodic memory in guiding behaviors such as goal-directed spatial navigation. This proposal investigates the neural circuits that support sensory cue representation, with a specific focus on the function of mature and adult generated granule cells and their inputs in the hippocampal dentate gyrus, a key brain region involved context encoding and spatial discrimination. This work will elucidate how multisensory cues are incorporated into episodic memories.

PI_NAMEs: TUNCDEMIR, SEBNEM NUR (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Acute;Adult;adult neurogenesis;Alzheimer's Disease;Animals;Behavior;Behavioral;Behavioral Paradigm;BRAIN initiative;Brain region;Calibration;career;Cells;clinically relevant;cognitive function;Complex;Computer Analysis;Cues;Data;dentate gyrus;design;Development;Discrimination;Disease;Dissection;Educational process of instructing;entorhinal cortex;Environment;Episodic memory;Evolution;experimental study;Fund Raising;Genetic;genetic approach;Goals;granule cell;Heterogeneity;Hippocampus;Image;Imaging Techniques;Impaired cognition;Impairment;in vivo calcium imaging;in vivo imaging;in vivo two-photon imaging;insight;irradiation;Knowledge;Laboratories;Lateral;Learning;Link;Location;Maps;Medial;memory encoding;Mentors;Mentorship;Methods;multisensory;Mus;neural;neural circuit;neural network;neurogenesis;neuroimaging;neuromechanism;Neurons;neuropsychiatric disorder;novel;Optics;optogenetics;Output;Parahippocampal Gyrus;parallel processing;Pattern;Phase;Physiology;Population;Positioning Attribute;Post-Traumatic Stress Disorders;programs;recruit;Research;Resolution;Rewards;Role;Running;Sensory;skills;Space Perception;Tactile;Techniques;Testing;Time;Training;treadmill;Viral;way finding;With laterality;Work

PROJECT_TITLE: Dissecting the neural circuit for discrete cue representation in the Dentate Gyrus

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: LITTLE ROCK

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PI_NAMEs: GRIFFIN, SUE TILTON (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Acute-Phase Proteins;Alzheimer's Disease;Alzheimer's neuropathogenesis;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-4;Astrocytes;Autophagocytosis;Binding;Brain;Brain Diseases;Brain region;brain tissue;Chemical Agents;chemical binding;Chronic;cytokine;Development;DNA;DNA Sequence;drug candidate;Drug Targeting;Event;Exhibits;Feedback;Functional disorder;gain of function;Genes;Genetic Transcription;Genotype;Glial Fibrillary Acidic Protein;Histologic;hyperphosphorylated tau;Individual;Inherited;Interleukin-1 beta;Lead;Microglia;Modification;Molecular;Motion;Neurofibrillary Tangles;neuroinflammation;Neurons;novel;Outcome;Parents;Pathogenesis;Patients;Pharmaceutical Preparations;Phosphotransferases;Play;Prevention strategy;Production;protein aggregation;Protein Inhibition;protein protein interaction;Proteins;Proteomics;Reporting;Repression;Role;small molecule;Stress;Testing;transcription factor;Work

PROJECT_TITLE: Neuroinflammation, Protein Aggregates, ApoE4 Drug Targeting, and Autophagy Rescue


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Suicide;Suicide Prevention;Telehealth

ORG_CITY: WORCESTER

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: NARRATIVE  In the last hour, over 100 patients have presented with suicide risk to emergency departments (EDs) and approximately 5 people have died by suicide in our country. The ED setting has strong potential to be an effective place to detect risk and intervene to reduce the chances of suicide, but current practices are insufficient, in large part because of poor access to behavioral health specialty care and tepid adoption of best- practices in suicide-related care. Our proposed study will address fundamental issues around leveraging telehealth service delivery models, both during the ED visit and afterwards, to help improve access to behavioral health specialty services, improve the quality of suicide-related care, and, ultimately, prevent suicide.

PI_NAMEs: BOUDREAUX, EDWIN D (contact)

PROGRAM_OFFICER_NAME: FREED, MICHAEL C

PROJECT_TERMS: Accident and Emergency department;acute care;Adherence;Adoption;Adverse event;behavioral health;Big Data;Caring;Cause of Death;Cessation of life;Clinical;clinical care;Clinical Services;Communities;comparative effectiveness;comparative effectiveness trial;Computer software;cost;cost effectiveness;Country;Data;data resource;Data Sources;Databases;design;Disease;effectiveness/implementation trial;Emergency Department patient;Emergency department visit;Environment;Evaluation;evidence base;Feedback;follow-up;Funding;Goals;Grant;Health;health care delivery;health care service;Health Technology;Healthcare;Healthcare Systems;Hospitalization;hospitalization rates;Hour;implementation barriers;implementation facilitators;implementation science;implementation strategy;Improve Access;improved;Incidence;indexing;Individual;innovation;inpatient psychiatric treatment;Interruption;Intervention;intervention effect;Intervention Studies;Investigational Therapies;Knowledge;Massachusetts;Measures;Mediating;medical specialties;Mental Health;mental health center;Methodology;Methods;Metric System;Modeling;Monitor;National Institute of Mental Health;Outcome;patient stratification;patient subsets;Patient-Focused Outcomes;Patients;Performance;Persons;Phase;Pragmatic clinical trial;Protocols documentation;provider behavior;Public Health;Quality of Care;Randomized;reducing suicide;Research Design;Research Personnel;Resources;Risk;Risk Assessment;Role;Safety;safety assessment;safety net;safety study;Sampling;Series;service delivery;Service delivery model;service intervention;Services;Site;Specialist;Structure;success;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide prevention;System;telehealth;Telemental;Telephone;Time;Training;translational model;treatment as usual;trend;United States;United States National Institutes of Health;Visit;Wait Time

PROJECT_TITLE: Telehealth to Improve Prevention of Suicide (TIPS) in EDs


ADMINISTERING_IC: EY

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Visual impairments are particularly disabling because they disrupt our ability to gather information critical for navigation. The retrosplenial cortex receives strong visual and hippocampal input, suggesting a central role in landmark processing. This proposal sets out to examine how the stability of landmark positions are learned and encoded by the retrosplenial cortex.

PI_NAMEs: BANERJEE, DHRUBA  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: adeno-associated viral vector;Anatomy;Animals;Area;Behavior assessment;Behavioral;Brain;Brain region;Calcium;cell cortex;Cells;cellular imaging;Communities;Data;density;design;Disabling;Disease;Disinhibition;Environment;excitatory neuron;experience;experimental study;Functional disorder;Functional Imaging;Head;Health;Hippocampal Formation;Hippocampus;Human;Human body;Image;imaging study;in vivo calcium imaging;information gathering;inhibitory neuron;insight;interest;Knowledge;Learning;Life;Location;Medical;Medicine;Memory;Monitor;mouse model;Movement;Mus;Nerve Degeneration;neural;neural circuit;Neurologic;Neurosciences;Patients;place fields;Population;Positioning Attribute;Process;promoter;Property;Rehabilitation therapy;Research;Role;Rotation;Route;Running;Scientist;Sensory;Site;Stroke;Structure;Synapsins;System;Tablets;Tactile;temporal measurement;Testing;Time;tool;Training;Translating;Traumatic Brain Injury;Trees;two-photon;virtual;virtual reality;virtual reality environment;virtual reality system;Vision;Visual;Visual Cortex;Visual impairment;visual memory;Visuospatial;way finding

PROJECT_TITLE: Retrosplenial Circuits Underlying Landmark Stability


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Epilepsy;Mental Health;Mental Illness;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The anterior insula is a component of the `anxiety network' and is heavily linked to anxiety-related symptoms. Nevertheless, the underlying role of insular circuits and their organization still remains unclear. We propose to use direct intracranial electrophysiological mapping with high density recordings to elucidate the functional organization of insular cortex in relation to dimensions of anxiety in patients with medication refractory epilepsy.

PI_NAMEs: LEE, ANDREW MOSES (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;advanced system;Affective;affective neuroscience;Anterior;Anxiety;Anxiety Disorders;anxiety spectrum disorders;anxiety states;anxiety treatment;associated symptom;Aversive Stimulus;Behavior;Biological Markers;Biometry;Brain;career;Clinical;Code;common symptom;Communication;comorbidity;conditioned fear;Data;density;diagnostic criteria;Dimensions;Electric Stimulation;Electroencephalography;Electrophysiology (science);Emotional;Epilepsy;Excision;experience;Extinction;Face;Facial Expression;Feeling;Frequencies;Goals;Human;Image;Impairment;Implant;improved;Individual;Insula of Reil;Interoception;Intervention;Intractable Epilepsy;Link;Maps;Measurement;Mediating;meetings;Mental disorders;Mental Health;Mentors;Methods;Modeling;Monitor;multimodality;National Institute of Mental Health;negative affect;neural;neural circuit;neural network;neurophysiology;neuroregulation;Neurosciences;new therapeutic target;novel;novel strategies;Patient Self-Report;Patients;Pattern;Pharmaceutical Preparations;Physiological;Pilot Projects;Population;Prevalence;Process;Psychiatrist;Quality of life;Recommendation;Reporting;Research;Research Personnel;Resolution;response;Role;Seizures;self-reported anxiety;severe mental illness;Shock;signal processing;Signal Transduction;Social Functioning;spatiotemporal;Structure;Symptoms;temporal measurement;Testing;theories;Training;Work

PROJECT_TITLE: Direct Intracranial Electrophysiological Mapping of Insular Circuits for Anxiety in the Human Brain


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: HOUSTON

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: Public Health Relevance Statement The objective of this proposal is to develop a next-generation micro-CT system that offers low-dose, fast x-ray phase-contrast imaging (PCI) for soft tissue imaging. Our proposed system will use cutting-edge high resolution spectral detectors, allowing direct comparison of PCI micro-CT with attenuation-based spectral micro-CT. PCI may provide significant reductions in dose coupled with enhanced contrast and higher fine- structure visibility as advantages for cancer research in animal models.

PI_NAMEs: DAS, MINI  (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: 3-Dimensional;absorption;Address;Algorithms;Animal Experiments;animal imaging;Animal Model;Animals;anti-cancer research;Area;attenuation;Blood;Blood Vessels;Calibration;Clinical;Collaborations;contrast enhanced;contrast imaging;Contrast Media;Contrast Sensitivity;cost;Coupled;Czech Republic;Data;design;Detection;detector;Development;Discrimination;Dose;electron density;experimental study;Geometry;Grant;Image;Image Enhancement;imaging capabilities;imaging modality;imaging study;improved;in vivo;in vivo imaging;industry partner;innovation;Iodine;Licensing;Liposomes;Longitudinal Studies;Malignant Neoplasms;Maps;Masks;Measurement;Measures;Methods;microCT;Mus;nanoparticle;next generation;novel;parametric imaging;Performance;Phase;phase change;photon-counting detector;Preclinical Drug Development;Process;Property;prostate cancer model;public health relevance;Qualifying;Radiation Dose Unit;Research Personnel;Resolution;Retrieval;Roentgen Rays;Scheme;sensor;Signal Transduction;simulation;soft tissue;Source;Structure;System;Task Performances;Technology;Testing;Thick;Time;Tissue imaging;Tissues;tomography;transmission process;treatment response;Tube;tumor;Universities;Variant;Vendor;Work

PROJECT_TITLE: Development of Spectral Phase Contrast Micro-CT


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Mountain View

ORG_NAME: REJUVENATION TECHNOLOGIES, INC.

PHR: Narrative mRNA treatments have the benefit of being quickly and precisely designed, and currently have been best suited for transient treatments with long lasting effects; RTI’s project concept that targets cellular uptake in progenitor cells advances the potential for mRNA therapeutic payload as these cells multiply in large numbers and differentiate into tissue-specific cells. As a result, with a single dose, RTI can achieve therapeutic results akin to repeated non-progenitor cell dosing, which has the potential to completely transform the global healthcare economy. Additionally, RTI’s platform allows for the testing of multiple different peptide-conjugated LNPs in a single subject and offers a novel, time efficient method for drug discovery.

PI_NAMEs: RAMUNAS, JOHN  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;Amino Acid Sequence;Antibodies;Bar Codes;base;Binding;Biological;Biological Assay;Biotechnology;Blood;Body Weight;Bone Marrow;Brain;Cell Aging;Cell division;Cell Proliferation;Cell Separation;Cell surface;Cell Surface Proteins;cell type;Cells;cellular targeting;Cessation of life;Chromosomes;Clinical;clinical development;delivery vehicle;design;Development;Disease;DNA;Dose;drug discovery;Encapsulated;Endosomes;Ensure;Fibroblasts;Fibrosis;Flow Cytometry;Formulation;Fostering;Gene Expression;Genes;global health;health care economics;healthspan;Histopathology;Immunologic Markers;in silico;In Vitro;in vitro testing;in vivo;Intestines;Intravenous infusion procedures;Libraries;Licensing;Ligands;lipid nanoparticle;Lipids;Liver Fibrosis;lung health;magnetic beads;Mediating;Medical;Messenger RNA;Methods;Microfluidics;Modeling;Molecular Conformation;mouse model;mRNA delivery;Mus;Myeloid Progenitor Cells;nanoparticle delivery;nerve stem cell;nonhuman primate;novel;Organ failure;Peptides;Phase;Process;programs;Protein Binding Domain;Proteins;Pulmonary Fibrosis;rational design;Regenerative capacity;regenerative cell;Regenerative Medicine;Rejuvenation;screening;Side;Software Tools;Solubility;Specificity;stem;stem cells;structural biology;System;Technology;Telomerase;telomere;Telomere Shortening;Testing;Therapeutic;Time;Tissues;Toxicology;Transfection;Translations;uptake

PROJECT_TITLE: Clinically-useful vehicles for in vivo delivery of mRNA to stem and progenitor cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-F (10)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_DEPT: PHARMACOLOGY

PHR: Public Heath Relevance/Narrative Protein-protein interactions, proteases and kinases play critical roles in mediating cell signaling. Perturbation of their activities can lead to many human diseases including cancer and infectious diseases. The proposed engineering of new classes signaling reporters will expand our capability in imaging the compartmentalized signaling dynamics, laying foundation for understanding disease mechanisms and identifying therapeutics for the treatment of various diseases.

PI_NAMEs: SHU, XIAOKUN  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Animals;Biological Process;Color;Communicable Diseases;design;Directed Molecular Evolution;Disease;Engineering;Foundations;Goals;human disease;Image;Kinetics;Malignant Neoplasms;Mediating;Molecular;multiplexed imaging;Names;Organism;Peptide Hydrolases;Pharmacotherapy;Phase;Phosphotransferases;Play;protein protein interaction;Proteins;public health relevance;rational design;Reporter;Resolution;Role;Scaffolding Protein;Signal Pathway;Signal Transduction;Specificity;Structure;Therapeutic;Visualization

PROJECT_TITLE: Designing a new class of fluorescent reporters for imaging dynamic cell signaling in live animals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-H (56)]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: DETROIT

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: The Wayne State University "Center for Urban Responses to Environmental Stressors (CURES)” strives to establish a cleaner and healthier living and working environment in the City of Detroit and other urban areas. A preponderance of our citizens disproportionately suffer the consequences of systemic racism, poverty, and environmental health disparities. CURES applies integrative teamwork, community-engaged research, and the latest technologies to understand how exposure to urban environmental chemical and non-chemical stressors affects human health. CURES seeks smart solutions that will reduce and ultimately eliminate the negative impact of these stressors.

PI_NAMEs: RUNGE-MORRIS, MELISSA A (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Address;Affect;African American;African American population;Age;Aging;Air;anti-racism;Area;Back;base;Behavioral;Black race;built environment;Cardiovascular Diseases;Characteristics;Chemical Exposure;Chemicals;Cities;Clinical;Collaborations;Communities;community engaged research;community engagement;community partners;Complex;Core Facility;Data;data to knowledge;Dedications;Diabetes Mellitus;Discipline;Disease;Disparity;Early Diagnosis;Eastern Europe;Economics;Environment;environmental chemical;Environmental Exposure;Environmental Health;environmental health disparity;environmental justice;Environmental Risk Factor;environmental stressor;Epidemiologist;Epidemiology;ethnic diversity;Ethnic Origin;Event;evidence base;Exposure to;field study;forging;Fostering;Fresh Water;Funding;Generations;Geography;Goals;Green space;Growth;Health;health equity;health science research;Healthcare;Healthcare Systems;Heart;Heavy Industries;Housing;Human;Incidence;Individual;Industrialization;Infrastructure;innovation;Institutional Racism;Internet;Justice;Knowledge;land use;Leadership;Life;Link;Locales;Malignant Neoplasms;Medical Records;member;Mentors;Michigan;Middle East;Middle Eastern;Modeling;National Institute of Environmental Health Sciences;Neighborhoods;next generation;Outcome;people of color;Physicians;Politics;pollutant;Pollution;Population;Population Heterogeneity;Positioning Attribute;Poverty;Predisposition;Premature Birth;Prevention;Psychosocial Factor;Public Health;Race;racial diversity;racism;recruit;Research;Research Personnel;Research Priority;Research Support;research vision;resilience;Resources;response;Safety;Sampling;Science;Scientist;Secure;Services;Severities;social;socioeconomics;Source;Strategic Planning;stressor;Surveys;synergism;System;Talents;Technology;toxicant;Translating;Translational Research;Universities;urban area;Urban Community;Urban Population;urban setting;Vision;Voice;Vulnerable Populations;Work

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS (P)]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Advisory Committees;Articulation;Awareness;Businesses;career;Career Mobility;Collaborations;Communication;Communities;community engagement;Core Facility;dashboard;Data;effectiveness evaluation;Ensure;Environment;Environmental Health;environmental stressor;equity, diversity, and inclusion;Evaluation;Event;expectation;Exposure to;Faculty;Feedback;Fostering;Funding;Goals;Health;Human;Human Resources;improved;Industrialization;insight;Institution;Interdisciplinary Study;Interest Group;Leadership;meetings;member;Mentors;National Institute of Environmental Health Sciences;operation;Performance;preservation;programs;Public Health;Publications;Research;Research Personnel;Resources;response;Scientific Advances and Accomplishments;Series;skills;stressor;success;symposium;technological innovation;Training;Translational Research;urban setting;Vision;Visualization

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: PARKER, GRAHAM C (contact)

PROJECT_TERMS: Affect;Awareness;Biometry;career;Chemicals;Cities;Clinical;Communities;community engagement;community partners;Consultations;Core Facility;dashboard;Data;data access;Data Science;design;Development;Disease;Early Diagnosis;Educational Materials;Ensure;Environmental Health;Environmental Risk Factor;environmental stressor;Epidemiology;Feedback;Geographic Information Systems;Goals;Health;health data;Health trends;Human;improved;innovation;Institution;Interest Group;Language;Link;Local Government;Malignant Neoplasms;Maps;Mediating;member;Michigan;Modeling;Multimedia;next generation;Outcome;Output;Palate;Performance;Pilot Projects;Population;population health;Prevention;Productivity;programs;Public Health;Publications;Research;Research Design;Research Personnel;Research Support;resilience;Resources;response;Risk;Science;Services;social;Social Environment;social health determinants;social stressor;State Government;Statistical Data Interpretation;statistics;stressor;Support System;System;tool;Training;Translating;translational goal;Translational Research;translational study;Translations;trend;trend analysis;Universities;virtual;Visualization;Voice;web site;Work

PROJECT_TITLE: Translational Research Support Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Social Determinants of Health

PI_NAMEs: STEMMER, PAUL M (contact)

PROJECT_TERMS: adduct;advanced analytics;analytical method;base;Bioinformatics;bioinformatics tool;Biological;Blood;Cells;Chemicals;Computer software;Consult;Consultations;Core Facility;cost;cytokine;Data;Data Analyses;Data Set;design;Development;Discipline;Disease;Disease Outcome;DNA Adducts;DNA Methylation;Elements;Environment;Environmental Exposure;environmental stressor;epigenomics;Etiology;experience;Experimental Designs;Exposure to;Flow Cytometry;Gene Expression;Generations;genome sciences;Genomic approach;Genomics;histone modification;Informatics;innovation;instrument;Laboratories;lipidomics;Lipids;Mass Fragmentography;Mass Spectrum Analysis;Mediator;metabolomics;Metals;Methodology;Methods;methylation pattern;Modeling;Performance;Phase;Phenotype;Physiological;Pilot Projects;Plasma;Post Translational Modification Analysis;Post-Translational Protein Processing;programs;Protein Analysis;Proteins;Proteome;Proteomics;Recommendation;recruit;Research;Research Personnel;Resources;response;Sampling;Science;Scientist;Services;Signaling Molecule;small molecule;stressor;Surveys;Technology;Tissues;toxicant;Toxicant exposure;Training;transcriptomics;Universities;Urine;voucher;Work;Xenobiotics

PROJECT_TITLE: Exposure Signatures Facility Core


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: LEACH, CARRIE  (contact)

PROJECT_TERMS: access disparities;Address;Advocacy;Advocate;African American;anti-racism;Chemicals;Cities;Collaborations;Communication;Communities;community advisory board;community engagement;Complex;Coping Skills;County;Decision Making;digital;Disparity;Education;Educational Curriculum;Educational workshop;Environment;Environmental Health;environmental health disparity;environmental justice;environmental stressor;Event;Exclusion;experience;Exposure to;Fostering;Foundations;Goals;Health;health disparity;health equity;Health Priorities;Health protection;Home;improved;Individual;Information Protection;innovation;Internet;Justice;Knowledge;Leadership;literacy;meetings;member;Methods;Michigan;Mission;older adult;Outcome;outreach;Persons;Policies;Policy Maker;Population Heterogeneity;Process;Race;Racial Equity;Research;Research Personnel;resilience;resilience biomarker;Resources;response;Science;Site;skills;skills training;social health determinants;stressor;Structural Racism;Training;Training Programs;Transportation;urban setting

PROJECT_TITLE: Community Engagement Core


PI_NAMEs: KOCAREK, THOMAS A (contact)

PROJECT_TERMS: Address;Advertising;Advisory Committees;Applications Grants;Area;Award;base;career;Career Mobility;Chemicals;Collaborations;Communities;community advisory board;community collaboration;community engagement;data submission;Development;Discipline;Environmental Exposure;Environmental Health;environmental stressor;Event;Extramural Activities;Funding;Funding Agency;Funding Opportunities;Goals;Grant;Health;health science research;improved;innovation;Knowledge;Letters;Measures;meetings;member;Monitor;National Institute of Environmental Health Sciences;next generation;Persons;Phase;Pilot Projects;preference;Process;programs;prospective;Publications;Request for Applications;Research;Research Personnel;Research Project Grants;Research Proposals;response;Science;Secure;skills;success;Testing;Time;Translational Research;Universities;Weight

PROJECT_TITLE: Pilot Projects


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Hematology;Rare Diseases;Sickle Cell Disease

ORG_CITY: Portland

ORG_NAME: HEMEX HEALTH, INC.

ORG_STATE: OR

PHR: PROJECT NARRATIVE One of the most common hemoglobin variants is homozygous sickle hemoglobin which leads to sickle cell disease (SCD), with an estimated 400,000 babies born annually with SCD and approximately 100,000 individuals living with SCD in the United States. Currently, there is no FDA-approved POC diagnostic device to detect Hb variants and quantify Hb-O2 affinity in hemoglobin disorders., and current laboratory and POC tests do not support treatment monitoring, especially for the new hemoglobin-oxygen affinity modifying therapies. This project aims to develop Gazelle Rapid Hemoglobin-Oxygen Dissociation Assay (RHODA) as the first POC diagnostic platform for screening and treatment monitoring for SCD by incorporating hemoglobin variant analysis and hemoglobin-oxygen affinity functional analysis in the same platform.

PI_NAMEs: GALEN, PETER  (contact);GURKAN, UMUT A.

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: absorption;Address;Affinity;Africa;Algorithm Design;Biological Assay;Blood;Blood specimen;Blood Tests;Carrying Capacities;Childhood;Chronically Ill;Clinical;Clinical Research;commercialization;commercialization readiness;cost;Country;Critical Illness;Diagnosis;diagnostic assay;Diagnostic Equipment;diagnostic platform;Diagnostic tests;Disease;Dissociation;Early Diagnosis;Ensure;Erythrocytes;FDA approved;Fluorescence;Genetic;Goals;Gold;Health;Hemoglobin;Hemoglobinopathies;High Pressure Liquid Chromatography;improved;in utero;Individual;Infrastructure;innovation;invention;Laboratories;Measurement;Measures;Methods;Monitor;Neonatal;Optics;Oxygen;Partial Pressure;Patients;Performance;Phase;Physiological;point of care;point of care testing;point-of-care diagnostics;Postpartum Period;preventable death;Price;Pyruvate Kinase;Quality of life;Rapid screening;rapid test;Reference Standards;Resource-limited setting;screening;Sickle Cell Anemia;Sickle Hemoglobin;Small Business Technology Transfer Research;Specificity;symptomatic improvement;Technology;Testing;Therapeutic;Time;TNFRSF5 gene;Transfusion;United States;Universities;Variant;variant detection

PROJECT_TITLE: RHODA: Rapid Hemoglobin-Oxygen Dissociation Assay

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (10)]


NIH_SPENDING_CATS: Biotechnology;Genetics;Prevention

ORG_CITY: BROOKLYN

ORG_NAME: MUTAGENTECH, INC.

PHR: PROJECT NARRATIVE Our project aims to improve and validate a cutting-edge DNA analysis technique called Single Molecule Mutation Sequencing (SMM-Seq) to accurately detect various types of genetic mutations. This innovation will provide a valuable tool for assessing the potential health risks associated with exposure to harmful substances in our environment, ultimately contributing to better public health and disease prevention.

PI_NAMEs: MASLOV, ALEXANDER Y.;SHARIFI, MOHAMED SAMIN (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Adverse effects;age-related disease;Ames Assay;analytical tool;anthropogenesis;Assessment tool;Automation;Biohazardous Substance;Biological Assay;Blood Cells;Businesses;Cancer Etiology;Cell Line;Cells;Chemicals;computational pipelines;cost effective;Cost efficiency;design;Detection;detection assay;Development;Diagnostic;disorder prevention;disorder risk;DNA;DNA analysis;DNA biosynthesis;DNA Damage;DNA Repair;DNA Sequence Alteration;DNA sequencing;Environment;Epidemiology;Evaluation;exposed human population;Exposure to;Face;Fibroblasts;Genetic;genetic risk assessment;Genome;genome integrity;genome-wide;Genotoxic Stress;Health;Human;improved;Individual;Industrialization;innovation;insertion/deletion mutation;Libraries;Lymphoma;Maintenance;Malignant Neoplasms;Marketing;Measures;Methods;Modification;Molecular;Monitor;Mus;Mutagenicity Tests;Mutagens;Mutation;Mutation Analysis;Mutation Detection;Normal Cell;Normal tissue morphology;novel strategies;Organism;Pathology;Phase;pilot test;predictive marker;Preparation;Protocols documentation;prototype;Public Health;Quality Control;Replication Error;Reproducibility;Research;Risk;Risk Assessment;Sampling;scale up;screening;single molecule;Single Nucleotide Polymorphism;Somatic Cell;Somatic Mutation;Speed;T-Lymphocyte;Techniques;Technology;technology platform;Testing;Tissues;tool;Toxic effect;Toxicogenetics;tumor;Variant

PROJECT_TITLE: Accurate and cost-effective detection of mutagenicity and mutagenic exposure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-G (15)]


ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE The Gulf Coast Center for Precision Environmental Health serves as a focal point and catalyst for environmental health sciences research across the Texas Medical Center. Its members from Baylor College of Medicine and the University of Texas work together with an active Community Engagement Core to drive precision environmental health research to prevent disease and improve human health, and promote career development of junior faculty. Research in the Center is accelerated by services provided by the PIPELINE and Translational Research Support Cores, and a Pilot Project Program that together advance our understanding of individual- and place-based environmental determinants of human health and disease.

PI_NAMEs: ELFERINK, CORNELIS JOHAN;WALKER, CHERYL L. (contact)

PROJECT_TERMS: Acceleration;Area;Award;base;career development;Career Mobility;catalyst;climate change;college;Communication;Communities;community advisory board;community center;community empowerment;community engagement;community partners;Core Facility;COVID-19;Disasters;Discipline;Disease;Educational workshop;Emerging Technologies;Ensure;Environment;Environmental Health;environmental health disparity;environmental justice;epigenome;Equity;equity, diversity, and inclusion;Exclusion;experience;Faculty;Fees;Fostering;fundamental research;Funding;Genome;Geography;Goals;Grant;gulf coast;Health;Health Disparities Research;Health Policy;health science research;Health Services Accessibility;Home;Human;Improve Access;improved;Individual;innovation;Institution;instrumentation;inter-institutional;Intervention;Investments;Justice;Leadership;leadership development;Link;Medical center;Medicine;member;National Institute of Environmental Health Sciences;next generation;outreach;Parents;Pilot Projects;Play;Policy Maker;Population;preference;prevent;Program Development;Program Effectiveness;programs;Publications;Reporting;Research;Research Personnel;Research Support;Resources;response;satisfaction;Services;Strategic vision;Structure;Superfund;Surveys;Technology;Texas;Time;Training;Training Programs;Translational Research;Translations;Universities;Veterans;Vision;Work


PI_NAMEs: WALKER, CHERYL L. (contact)

PROJECT_TERMS: Acceleration;Administrator;Advisory Committees;Annual Reports;Area;Award;base;career;career development;Career Mobility;catalyst;climate change;college;Communication;Communities;community advisory board;community engagement;Community Health;Core Facility;COVID-19 pandemic;data management;Data Science;Development;Disasters;Disease;Educational workshop;Effectiveness;Ensure;Environment;Environmental Health;environmental justice;epigenome;epigenomics;Evaluation;experience;Extramural Activities;Faculty;Funding;Genome;Genomics;Goals;Grant;Growth;gulf coast;Health;Health Policy;health science research;health science research support;Human;improved;Individual;Infrastructure;Institution;Intervention;Leadership;leadership development;Medical center;Medicine;meetings;member;National Institute of Environmental Health Sciences;Outcome;outreach;Parents;Participant;Pilot Projects;Policy Maker;population health;Positioning Attribute;Preparation;Program Development;programs;Publications;Recommendation;Reporting;Research;Research Personnel;response;Strategic vision;Structure;Surveys;symposium;Texas;Time;Translational Research;Translations;Universities;Veterans;web site;Writing


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SYMANSKI, ELAINE  (contact)

PROJECT_TERMS: Achievement;Adult;Agriculture;Area;biobank;Biological;cancer health disparity;Child;Child Nutrition;climate change;climate impact;Clinical;Clinical Sciences;Collaborations;Communities;community engaged research;community engagement;Community Health;community partners;cost effectiveness;Development;Disasters;Disease;Education and Outreach;Educational workshop;Environment;Environmental Health;environmental health disparity;epidemiology study;epigenome;Equity;ethnic diversity;Extramural Activities;follow-up;Fostering;Funding;Genome;Grant;gulf coast;hazard;Health;Health Disparities Research;health disparity populations;health science research;Human;Hurricane;improved;Industrialization;Infrastructure;Institution;Intervention;Laboratories;laboratory facility;leadership development;life span;member;Metabolic;Minority;National Institute of Environmental Health Sciences;Neighborhoods;Nutritional Study;Outcome;outreach clinics;Parents;Patient Recruitments;Perinatal;phenotypic data;Pilot Projects;Play;Policy Maker;population based;population health;Population Sciences;Population Study;Program Development;programs;prospective;Publications;racial diversity;Research;Research Design;Research Personnel;Research Support;Resource Sharing;Resources;response;Role;Sampling;Services;Site;Specialized Program of Research Excellence;Strategic vision;Surveys;symposium;synergism;Talents;Translational Research;Translations;United States National Institutes of Health;Veterans;Vision;volatile organic compound;wasting;web portal;Work


NIH_SPENDING_CATS: Genetics;Human Genome;Prevention

PI_NAMEs: AMOS, CHRISTOPHER I. (contact)

PROJECT_TERMS: Acceleration;Area;Award;base;Bioinformatics;career;career development;Cells;Collaborations;college;Complex;Consultations;Core Facility;cost;Data;data acquisition;Data Analyses;data integration;design;Disease;Education;education resources;Educational workshop;Emerging Technologies;Ensure;Environmental Exposure;Environmental Health;epigenomics;Fees;Funding;Generations;Genomics;Goals;gulf coast;Health;health science research;Human;improved;Individual;Institution;instrumentation;Intervention;Knowledge;Leadership;leadership development;Medical;Medicine;member;Mentors;metabolomics;Metagenomics;Methods;microbiome;Multiomic Data;multiple omics;new technology;operation;Organism;Paper;Parents;Pilot Projects;prevent;Prevention strategy;Program Development;programs;Proteomics;Publications;Publishing;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;Risk;Role;Sampling;satisfaction;Services;Structure;Surveys;System;Technology;Texas;Tissues;Training;Training and Education;transcriptomics;Translational Research;Universities;user-friendly;Vision;Work

PROJECT_TITLE: PIPELINE Facility Core


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

PI_NAMEs: CROISANT, SHARON A (contact)

PROJECT_TERMS: Address;Adopted;Area;Awareness;Back;Caring;climate change;Clinical;college;Color;Communication;Communities;community advisory board;community based participatory research;community empowerment;community engaged research;community engagement;community engagement process;community involvement;Community Networks;community partners;community partnership;Country;Data;Decision Making;design;Disasters;effectiveness evaluation;Environmental Exposure;Environmental Health;Environmental Impact;environmental justice;Environmental Policy;Environmental Pollution;Environmental Science;Equity;equity, diversity, and inclusion;experience;Floods;Fostering;Goals;Government;gulf coast;Health;health communication;health literacy;Health Policy;health science research;Health Services Administration;Home;Improve Access;improved;Individual;information gathering;innovation;Institution;interest;Justice;Knowledge;Leadership;Link;man-made disasters;Medicine;member;military veteran;multimodality;outreach;Parents;Policies;Policy Maker;Policy Making;pollutant;Population Heterogeneity;Poverty;Process;Program Effectiveness;Public Health;Public Policy;Recovery;Research;Research Personnel;resilience;Resources;response;Risk;Science;Scientist;Services;social;Source;Texas;Translating;Translational Research;Translations;Trust;Universities;Veterans;Veterans Health Administration;Vision;Vulnerable Populations;Water;Work


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions

PI_NAMEs: ELFERINK, CORNELIS JOHAN (contact)

PROJECT_TERMS: Acceleration;Achievement;Address;Advisory Committees;Applications Grants;Area;Award;base;Budgets;career development;Career Mobility;climate change;college;Committee Members;community engagement;COVID-19 pandemic effects;Data;data acquisition;Dedications;design;Disasters;Discipline;Effectiveness;Environmental Health;experience;Extramural Activities;Faculty;Funding;Funding Mechanisms;Generations;Goals;Grant;gulf coast;Health;health science research;Human;improved;Institution;Investigation;Investments;Knowledge;Leadership;Manuscripts;Measures;Medical;Medical center;Medicine;member;Mentors;Mission;National Institute of Environmental Health Sciences;novel;Parents;Peer Review;Pilot Projects;Play;Productivity;programs;Publications;recruit;Research;Research Personnel;Research Project Grants;response;Role;Strategic Planning;success;Texas;Time;Translating;Universities;Veterans;Vision

PROJECT_TITLE: Pilot Project Program


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Machine Learning and Artificial Intelligence;Nanotechnology;Orphan Drug;Rare Diseases

ORG_NAME: UBIQUITX, INC.

PHR: NARRATIVE UbiquiTx is pioneering a new class of computationally-designed mRNA therapeutics that encode peptide-guided protein degraders, known as ubiquibodies (uAbs), for potent and selective degradation of historically undruggable targets not addressable by conventional drugs. To further advance our platform, this Phase I STTR project seeks to design customized uAbs against β-catenin and CCAAT/enhancer-binding protein homologous protein (CHOP), two intracellular transcription factors that hold promise as drug targets for hepatocellular carcinoma (HCC), alpha-1 antitrypsin deficiency (AATD), and other liver diseases. By accelerating the removal of these two key intracellular disease drivers through LNP-mediated delivery of mRNA encoding peptide-guided uAbs, these studies will provide important proof-of-concept for our unconventional approach to drugging the proteome.

PI_NAMEs: CAMARGO, LUIZ MIGUEL QUINN (contact)

PROJECT_TERMS: Acceleration;Address;Advanced Development;Affinity;Alleles;alpha 1-Antitrypsin Deficiency;Animal Model;Area;Artificial Intelligence;Artificial Intelligence platform;Base Sequence;beta catenin;Binding;Biodistribution;Biological;c-myc Genes;CCAAT-Enhancer-Binding Proteins;Cell Nucleus;Cells;Chimera organism;Clinical;Colorectal Cancer;commercialization;Cultured Cells;Cyclin D1;Cytosol;Degradation Pathway;design;Development;Disease;drug development;drug discovery;Drug Targeting;Ectopic Expression;Encapsulated;endoplasmic reticulum stress;Evaluation;Excision;Family;Formulation;Future;generative artificial intelligence;Genes;Genetic Engineering;Hepatic;Homologous Protein;Human;Human Cell Line;Human Genome;Induction of Apoptosis;innovation;interest;Lead;lipid nanoparticle;Liver;liver cancer model;Liver diseases;liver injury;Location;Machine Learning;Malignant Neoplasms;Mediating;Medicine;member;Messenger RNA;Methodology;Modernization;Modification;Molecular Conformation;mRNA delivery;multicatalytic endopeptidase complex;Mus;mutant;Mutation;new technology;next generation;novel;novel strategies;Nuclear;Oncogenes;Outcome;Pathogenicity;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Phosphorylation;Polymers;Polyubiquitination;prevent;Primary carcinoma of the liver cells;protein degradation;Protein Engineering;Protein Isoforms;Proteins;Proteome;proteotoxicity;rational design;Role;Serine Proteinase Inhibitors;Signal Transduction;Small Business Technology Transfer Research;Structure;Technology;Testing;Therapeutic;therapeutic candidate;Toxic effect;trait;transcription factor;Transfection;tumorigenic;Ubiquitin;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Computational design and evaluation of peptide-guided protein degraders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-G (10)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Nanotechnology;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: BUFFALO

ORG_NAME: POP BIOTECHNOLOGIES, INC

PHR: Narrative Patients with inoperable locally advanced hepatocellular carcinoma (HCC) have a 5-year survival rate of just 31%. POP BIO seeks to advance its novel interstitial chemo-phototherapy (I-CPT) therapeutic that combines PhotoDox, POP BIO’s light-activated liposomal formulation of doxorubicin, with MRI treatment planning developed by PI to provide a potent therapeutic option for locally advanced HCC. This proposal seeks funds to generate IND-enabling pharmacokinetic data of doxorubicin; doxorubicinol, the major metabolite of doxorubicin; and PPa-lipid, the excipient responsible for phototherapy, in the plasma of rats and dogs as well as the assess the accelerated stability of PPa-lipid and PhotoDox.

PI_NAMEs: KUTSCHER, HILLIARD  (contact)

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: Ablation;Acceleration;Animal Model;Award;Biotechnology;Canis familiaris;Capital;Chemoembolization;chemotherapy;Cholesterol;Clinical;Clinical Research;clinical translation;cohort;commercialization;Curative Surgery;Data;dosimetry;Doxorubicin;Doxorubicin Hydrochloride Liposome;Drug Kinetics;Drug Packaging;Excipients;Exhibits;first-in-human;Formulation;Foundations;Funding;Future;Generations;Goals;Grant;High Pressure Liquid Chromatography;improved;Innovation Corps;Intellectual Property;interstitial;Investigational Drugs;Investigational New Drug Application;Investments;Lasers;Licensing;Light;light dosimetry;Lipids;liposomal formulation;Liposomes;liquid chromatography mass spectrometry;liver cancer patient;Magnetic Resonance Imaging;Malignant neoplasm of liver;manufacture;Marketing;Maximum Tolerated Dose;Measures;Medical;metabolomics;Methods;microwave electromagnetic radiation;Modality;Modeling;nanoparticulate;novel;novel therapeutics;Parents;Patients;Pharmaceutical Preparations;pharmacokinetic model;Pharmacologic Substance;Phase;Phospholipids;Phototherapy;Physicians;Plasma;Porphyrins;Pre-Clinical Model;pre-Investigational New Drug meeting;Primary carcinoma of the liver cells;Primary Neoplasm;programs;PUVA Photochemotherapy;Radio;radio frequency;Rattus;Readiness;Request for Applications;Research;Resource Sharing;response;Route;Safety;Sampling;Serum;Site;Small Business Technology Transfer Research;stability testing;Survival Rate;Therapeutic;therapeutic effectiveness;Therapeutic Embolization;Thermal Ablation Therapy;Time;Tissues;Toxic effect;Toxicokinetics;Toxicology;treatment optimization;treatment planning;tumor;tumor ablation;United States National Institutes of Health;Vascular Permeabilities;Woodchuck

PROJECT_TITLE: Clinical Translation of Interstitial Chemophototherapy with Light-Activated Nanoparticulate Doxorubicin

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-K (19)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: COLLEGE STATION

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: Overall NARRATIVE The vision for the Texas A&M Center for Environmental Health Research (TiCER) is to nucleate environmental health research and translational activities of investigators around the overarching theme of “Innovative solutions for addressing exposure-stressor interactions with a focus on underserved populations in urban and urbanizing areas” in the state of Texas. Overall, the Center will expand the established investigator base and expertise in cross-cutting environmental health science that can be deployed to increase the impact of environmental health research change in Texas and beyond.

PI_NAMEs: PORTER, WESTON W (contact)

PROJECT_TERMS: Address;Administrator;Affect;Applied Research;Area;Back;base;career;career development;Career Mobility;climate change;climate-related health;Collaborations;college;Communication;Communities;community engaged research;community engagement;Community Services;Core Facility;Data;Data Science;Data Science Core;Decision Making;Disease;Doctor of Philosophy;educational atmosphere;Ensure;Environment;Environmental Exposure;Environmental Health;environmental health disparity;Environmental Impact;environmental justice;Environmental Policy;Environmental Risk Factor;Faculty;Fostering;fundamental research;Goals;Health;In Vitro;in vivo Model;Individual;Infrastructure;innovation;Institution;instrumentation;Interdisciplinary Study;interest;International;Investigation;Investments;Knowledge;Leadership;Link;member;Mentors;Metabolism;Mission;model development;multidisciplinary;Nature;novel;Outcome;outreach;Persons;Pilot Projects;Policies;Policy Making;Population;prevent;programs;Public Health;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resources;response;Science;stressor;success;synergism;Technology;Texas;Toxicology;Translating;Translational Research;Translations;Underserved Population;Universities;Urbanization;Vision


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Address;Area;career;career development;Collaborations;college;Communication;community engagement;Core Facility;design;Discipline;Doctor of Philosophy;Ensure;Environmental Health;Evaluation;Faculty;Funding Opportunities;Future;Goals;Growth;Human Resources;improved;Infrastructure;innovation;Internet;Leadership;Medical;meetings;member;Mentors;Mentorship;Mission;National Institute of Environmental Health Sciences;Outcome;outreach;Performance;Pilot Projects;Program Development;Program Evaluation;programs;recruit;Reporting;Research;Research Personnel;stressor;Structure;Texas;Training;translational goal;Translational Research;Travel;Underserved Population;Universities;Urbanization

PROJECT_TITLE: Texas A&M Center for Environmental Health Research (TiCER)


NIH_SPENDING_CATS: Bioengineering;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: JOHNSON, NATALIE M (contact)

PROJECT_TERMS: Acceleration;Accountability;Address;Animal Model;Animals;Area;Award;Biological Models;career;career development;Cells;Chemicals;Collaborations;Communication;Communities;community center;community engagement;Computing Methodologies;Core Facility;Coupled;Cryoelectron Microscopy;Dedications;Discipline;Educational Curriculum;Educational workshop;empowerment;Environment;Environmental Exposure;Environmental Health;Environmental Risk Factor;Equity;experience;Experimental Designs;Experimental Models;experimental study;Exposure to;Funding;Gene Knock-Out Model;Goals;Health Sciences;Human;human disease;human model;human subject;Image;Imaging technology;improved;In Vitro;in vitro Model;in vivo;Individual;induced pluripotent stem cell;Inhalation;innovation;Institution;instrument;instrumentation;interdisciplinary collaboration;International;Investments;Lead;Leadership;meetings;member;Metabolism;Methodology;Methods;mid-career faculty;Modeling;Molecular;molecular phenotype;Mus;National Institute of Environmental Health Sciences;novel;novel strategies;Organoids;Outcome;Phenotype;Physiological;Pilot Projects;Policy Making;Population;Process;Public Health;Publications;Research;Research Personnel;Research Support;Resolution;Resources;response;Role;Science;service member;Source;Stress;stressor;success;Technology;Texas;Tissue Microarray;tool;Toxicology;Training;Transgenic Organisms;translational barrier;translational framework;translational goal;Translational Research;translational study;Translations;Underserved Population;Universities;Update;Urbanization;voucher;whole genome;Work


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

PI_NAMEs: CHIU, WEIHSUEH A (contact)

PROJECT_TERMS: Address;Algorithms;Area;Bioinformatics;Biological;Biometry;Cells;Chemicals;climate change;climate-related health;Communication;Communities;Complex;Complex Analysis;complex data;Computational Biology;Computer software;Core Facility;Data;Data Collection;data integration;data integrity;data management;data mining;data repository;data reuse;Data Science;Data Security;Data Set;data streams;Decision Making;Derivation procedure;design;Development;diverse data;Doctor of Philosophy;Dose;Elements;Ensure;Environment;Environmental Exposure;Environmental Health;environmental justice;Environmental Policy;environmental stressor;experience;exposed human population;Faculty;flexibility;Funding;Genomics;Geographic Information Systems;Goals;hazard;Hazard Identification;Health;high dimensionality;Human;Human Resources;Image;indexing;Individual;innovation;Interdisciplinary Study;Intervention;Investigation;Knowledge;large datasets;Mathematics;member;Metabolism;Metagenomics;Methods;Mission;Modeling;novel;open data;open source;operation;Outcome;outreach;Pattern;Pilot Projects;Policies;Policy Maker;Population;Positioning Attribute;Predisposition;Process;Public Health;repository;Research;research faculty;Research Personnel;Resources;response;Rest;Risk;Risk Assessment;Science;Security;Services;single-cell RNA sequencing;Source;spatiotemporal;Statistical Models;stressor;structured data;Students;Techniques;Texas;Toxic effect;Toxicokinetics;transcriptomics;Translating;Translational Research;Translations;Uncertainty;underserved community;Underserved Population;Universities;unstructured data;Urbanization;usability;Vision;Visualization;Work


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: NEWMAN, GALEN  (contact)

PROJECT_TERMS: Acceleration;Acute;Address;Air;Area;citizen science;climate change;climate impact;Collaborations;Communication;Communities;community engagement;Community Health;community organizations;community partnership;community transmission;Coupled;crowdsourcing;Data;Data Collection;Decision Making;design;Development;Disasters;Disparity;Educational workshop;Elements;Emergency Situation;environmental change;Environmental Hazards;Environmental Health;Environmental Impact;environmental justice;Environmental Risk Factor;Evaluation;Event;evidence base;Evidence based intervention;experience;Exposure to;Face;Faculty;Future;Generations;Goals;Growth;hazard;Hazard Identification;Health;Health Priorities;high school;improved;Individual;Inequality;Inequity;Infrastructure;innovation;Intervention;Investments;Knowledge;Lead;man;marginalization;member;Mission;multidisciplinary;Neighborhoods;Outcome;outreach;Persons;Pilot Projects;Play;Policies;Policy Maker;Policy Making;Positioning Attribute;Prevention strategy;Productivity;promote resilience;Public Health;Public Participation;Recording of previous events;Regulation;Research;Research Personnel;resilience;Resources;Risk;Risk Assessment;Risk Reduction;Role;Sampling;scale up;Science;science education;Scientist;Soil;stressor;Students;Techniques;Testing;Texas;tool;Training;Translational Research;Translations;Trust;underserved community;Underserved Population;Urbanization;Water;Work


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: BANU, SAKHILA  (contact)

PROJECT_TERMS: Applications Grants;Area;base;Basic Science;Center Core Grants;climate change;climate-related health;Collaborations;college;Communities;community engagement;Consultations;Core Facility;Development;Elements;Environmental Health;expectation;Faculty;Funding;Future;Goals;Grant;Growth and Development function;Health;improved;Individual;Lead;Letters;Notification;novel;Outcome;Pilot Projects;Play;programs;recruit;Research;Research Activity;research facility;research faculty;Research Personnel;Resources;Role;Schools;Science;Scientist;Structure;Superfund;Texas;Toxicology;Training;underserved rural area;Universities;volunteer


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE HIV infects macrophages in the spinal cord, often leading to clinical symptoms even with antiretroviral treatment (ART). In the spinal cord, macrophages may serve as long-term cellular reservoirs of latent HIV; replication competent HIV can emerge from these latent reservoirs if ART is stopped. Our proposed studies to identify the cell types in the spinal cord harboring SIV combined with spinal cord gene expression profiling will advance our understanding of the role that spinal cord macrophages play in HIV latency.

PI_NAMEs: MANKOWSKI, JOSEPH L (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acute;acute infection;Animals;antiretroviral therapy;Astrocytes;Binding;Biological Assay;Blood Vessels;Brain;CCL2 gene;Cd68;Cell Separation;cell type;Cells;cellular targeting;Classification;Clinical;Complement;CSF1R gene;Disparity;DNA;Gene Expression Profile;Gene Expression Profiling;Genes;Glial Fibrillary Acidic Protein;HIV;Immune response;immunoregulation;Infection;inhibitor;Interruption;Kinetics;latent HIV reservoir;Lumbar spinal cord structure;Macaca;Macaca nemestrina;Macrophage;Macrophage Activation;Microglia;model building;Modeling;Nature;Neuroimmune;neuroinflammation;Plasma;Play;Population;Production;reactivation from latency;Regulation;Research;response;RNA;Role;single-cell RNA sequencing;SIV;Spinal Cord;Symptoms;Thoracic spinal cord structure;TNF gene;Viral;viral rebound

PROJECT_TITLE: The Spinal Cord as a CNS Latent Reservoir for Replication Competent SIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE We will collect data in a large treatment cohort [N=200 Alcohol Use Disorder (AUD), >40% female; enrollment at 2-5 weeks into treatment,; N=100 controls] using a multi-method approach (personality, neurocognition, clinical assessments, task/resting fMRI brain function) to assess function across three different domains (reward reactivity, aversive reactivity, executive control). We hypothesize that relapse in AUD is driven by different combinations of these three factors in each individual. We will test this hypothesis by using novel analytical approaches to parse out individual heterogeneity in the multivariate patterns of impairments underlying relapse in dependent alcohol users.

PI_NAMEs: ZILVERSTAND, ANNA  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: addiction;Adult;Alcohol abuse;Alcohol dependence;alcohol use disorder;Alcohols;artificial neural network;Automobile Driving;Behavior;behavior prediction;behavioral impairment;Big Data Methods;Brain;Chronic;Clinical;Clinical assessments;cohort;Communities;Data;Data Set;design;Development;disorder subtype;drug of abuse;Drug user;Emotional;Enrollment;executive function;explainable machine learning;Female;Functional Magnetic Resonance Imaging;Goals;Haemophilus influenzae type b;Heterogeneity;high reward;high risk drinking;impaired driving performance;Impairment;Individual;Individual Differences;individual variation;innovation;interest;Investigation;Link;Machine Learning;machine learning method;Maintenance;male;Measures;Methods;Modeling;neurobehavioral;Neurocognition;neuroimaging;Normal Range;novel;Pattern;Personality;personalized medicine;predictive modeling;predictive tools;Prevalence;preventive intervention;Recovery;Relapse;relapse prediction;relapse prevention;relapse risk;Rest;Rewards;Sampling;Seminal;Structure;Testing;Time;Work

PROJECT_TITLE: Personalized relapse prediction in Alcohol Use Disorder

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: GA

PHR: Most veterans will develop atherosclerotic cardiovascular disease (CVD) during their lifetime. Research to date has largely focused on the role of traditional risk factors and the occurrence of CVD outcomes. Genes and the environment work in concert to foster the development of traditional risk factors and subsequently increase the risk for clinical vascular disease. This project provides the opportunity to investigate the role of genes and environment as causative in the development of the risk factors and the association of genes with CVD itself. It also expands the scope to include new CVD risk factors including blood cell indices, inflammatory conditions, valvular heart disease, obstructive sleep apnea, and atrial fibrillation. The project we describe creates the framework for the VA to participate in the process for CVD research concerning MVP assessment, risk factors and CVD outcomes.

PI_NAMEs: WILSON, PETER WYMAN (contact)

PROJECT_TERMS: Address;adjudication;African American;African American population;Age;Alcohol consumption;Ambulatory Care;American;Atherosclerosis;Atrial Fibrillation;Bioinformatics;Blood Cells;blood glucose regulation;Blood Pressure;Body mass index;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular effects;cardiovascular risk factor;Cessation of life;Classification;clinical diagnosis;clinical risk;cohort;Cohort Studies;Complete Blood Count;Coronary Artery Bypass;Coronary heart disease;Data;Data Element;Data Sources;Databases;Development;Diabetes Mellitus;Diet;Disease;Disease Outcome;Electronic Health Record;Elements;Enrollment;Environment;Ethnic Origin;European;Event;Food;Fostering;Frequencies;Funding;Future;Genes;Genetic;Genetic Risk;genetic risk factor;genetic variant;Genetic Variation;genome wide association study;Glycosylated hemoglobin A;Health;healthy aging;heart disease risk;Heart Valve Diseases;High Density Lipoprotein Cholesterol;Hispanic Americans;Incidence;indexing;Inflammatory;Inflammatory Arthritis;Intake;Investigation;LDL Cholesterol Lipoproteins;Link;Lipids;longitudinal, prospective study;Measurement;Measures;Medicare;Methods;Myocardial Infarction;Nutrient;Obstructive Sleep Apnea;Outcome;Outpatients;Participant;Patient Self-Report;percutaneous coronary intervention;Pharmacological Treatment;Phenotype;Physical activity;Population Group;post stroke;precision medicine;predictive modeling;Prevalence;Primary Care;Process;professional atmosphere;programs;prospective;Questionnaires;Race;rare variant;Recording of previous events;Recurrence;Research;Research Design;Risk;Risk Estimate;Risk Factors;risk prediction;Role;sex;Smoking;Stroke;structural heart disease;Subgroup;survival outcome;survivorship;Techniques;Testing;Time;trait;Triglycerides;valvular stenosis;Variant;Vascular Diseases;Veterans;virtual;Visit;White Blood Cell Count procedure;Work

PROJECT_TITLE: Cardiovascular Disease Risk Factors, Cardiovascular Disease Risk Prediction, and Genetics in the Million Veteran Program


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Complementary and Integrative Health;Neurosciences

ORG_CITY: Los Angeles

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Age-related cognitive impairments co-occur with the disruption of molecular signaling within the brain, but the basic mechanisms of this relationship are unclear. In the proposed research project, we will investigate the mechanisms by which changes in the activity of the noradrenaline signaling molecule modulates the increased distractibility by task-irrelevant information seen in older adults and whether managing baseline levels can improve attentional control. The findings in both older and young adults will contribute critical knowledge on how the changes in molecular signaling activity in the brain modulates behavior, which will inform therapeutic approaches in how to control the activity of these signaling molecules to prevent cognitive decline.

PI_NAMEs: KIM, ANDY JEESU (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Address;Affect;affective neuroscience;age difference;age related;age related decline;Age-associated memory impairment;Aging;Anterior;anxiety states;Arousal;Attention;attentional control;attentional modulation;Autopsy;Behavior;Behavioral;Brain;Breathing;career;Career Choice;Cognitive;cognitive performance;Conscious;Coupled;Coupling;Data;design;Development;Electroencephalography;Electrophysiology (science);empowerment;Eye Movements;Fellowship;Foundations;Frequencies;Functional Magnetic Resonance Imaging;Future;Goals;hallmarks of aging;Hyperactivity;Impaired cognition;Impairment;improved;Individual;Intervention;Knowledge;Link;locus ceruleus structure;mathematical model;Measures;Mentorship;Methodology;mindfulness;Mindfulness Training;Molecular;Mydriasis;Nature;Neurodegenerative Disorders;neuroimaging;Neurons;neuroprotection;neuroregulation;Neurosciences Research;noradrenergic;Norepinephrine;novel;oculomotor;older adult;Phase;pre-doctoral;preservation;prevent;Process;Psychophysiology;Pupil;Research;Research Personnel;Research Project Grants;Respiration;respiratory;response;Rest;Role;Shock;Signal Transduction;Signaling Molecule;skills;Source;Stimulus;Therapeutic;tool;Training;visual search;young adult

PROJECT_TITLE: The effects of noradrenergic activity on age-related distractibility


ORG_CITY: ANN ARBOR

PHR: For the past 30 years, the VA has been a leader in measuring the quality of surgical care. However, most of the VA’s work has focused on quality outcomes that happen after surgery. There is a need to develop new reliable and more accurate measures of quality of care for the Veteran’s entire health care journey, both before and after surgery. The goals of the current study are to develop an approach for measuring the quality of Veterans’ full surgical experience (the “surgical episode”) for three common surgical procedures and to apply this approach to VA and Community Care settings in which Veterans receive care. This work will advance the science of quality measurement to more thoroughly assess quality before, during, and after surgery in order to identify opportunities for quality improvement. The proposed study will also compare VA and Community Care quality, providing recommendations to improve quality measurement for Community Care, and helping to inform Veterans about their choices for surgical care in VA and Community Care settings.

PI_NAMEs: SEARS, ERIKA D (contact)

PROJECT_TERMS: Attention;Authorization documentation;care delivery;care episode;care systems;Caring;Clinical;Communities;Community Healthcare;Continuity of Patient Care;cost;Data;Data Sources;Evaluation;experience;Face;Future;Goals;Healthcare;Healthcare Market;Hospitals;improved;Inguinal Hernia;innovation;knee replacement arthroplasty;Measurement;Measures;Medical;Medical center;Methodology;Methods;Modeling;Monitor;Operative Surgical Procedures;Outcome;Participant;Patient Care;Patients;Performance;Perioperative;Phase;Policies;Postoperative Care;Postoperative Complications;Postoperative Period;Procedures;Process;programs;Provider;Quality of Care;Recommendation;repaired;Reporting;Research;response;Risk Adjustment;Risk Assessment;Scanning;Science;Services;Standardization;Time;Tracer;Variant;Veterans;Work

PROJECT_TITLE: Assessing Episode-Based Surgical Quality in VA and Community Care Settings

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Eye Disease and Disorders of Vision;Immunotherapy

ORG_CITY: Chicago

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE We present an innovative pathophysiological concept: Dry Eye Disease (DED) is characterized by breach of self-tolerance towards citrullinated antigens with generation of autoantibodies. Neutrophil Extracellular Traps could represent a source of citrullinated antigens fueling the autoimmune response over the ocular surface, creating a self-perpetuating cycle of chronic inflammation. Because pooled human immune globulins contain anti-idiotypic antibodies that inhibit the pathogenic actions of autoantibodies, we propose to formulate them as eye drops for use as the first topical biologic immunotherapy for DED.

PI_NAMEs: JAIN, SANDEEP  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Acute;analytical method;Animals;Anti-citrullinated peptide antibody;Anti-Idiotypic Antibodies;Antigens;Applications Grants;Arginine;Autoantibodies;autoimmune inflammation;Autoimmune Responses;Benzalkonium Chloride;Biological Immunotherapy;Biological Markers;Cells;Characteristics;Chromatin;Chronic;citrullinated protein;Citrulline;Clinical;clinical practice;Clinical Research;Clinical Trials;Cornea;corneal epithelium;Data;Deoxyribonucleases;design;Disease;disorder subtype;drug development;Drug Kinetics;Drug or chemical Tissue Distribution;Dry Eye Syndromes;efficacy study;efficacy testing;Enzymes;Epithelial Cells;experience;extracellular;Eye;Eyedrops;first-in-human;Formulation;Functional disorder;Generations;Goals;good laboratory practice;graft vs host disease;Grant;Human;Immunoglobulins;Immunologics;Immunotherapy;In Vitro;in vivo;Inflammation;Inflammatory;inhibiting antibody;innovation;Internet;Intravenous Immunoglobulins;Investigational Drugs;Investigational New Drug Application;Liquid substance;manufacture;Mediating;Mediation;meibomian gland;Methods;Modeling;mouse model;multidisciplinary;Names;neutrophil;New Zealand;novel;ocular surface;ocular surface disease;ophthalmic drug;Oryctolagus cuniculus;Pathogenicity;Pathologic;Patients;Positioning Attribute;Post-Translational Protein Processing;pre-clinical;preclinical efficacy;Process;Production;Protein-arginine deiminase;Proteins;Qualifying;R24;receptor;Recombinant Immune Globulin;Regulation;Safety;safety study;Self Tolerance;Serum;Signs and Symptoms;Sjogren's Syndrome;Source;Stratification;Surface;symposium;Symptoms;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Toxic effect;Toxicology;translational research program;United States Food and Drug Administration

PROJECT_TITLE: Immunotherapy for Ocular Surface Diseases


ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: Over 1 million Black and 0.5 million Hispanic Veterans are enrolled in the Veterans Health Administration (VHA) and the percentage of race and ethnic minorities served by the VHA is expected to continue to increase over the next several decades. Hypertension is the most common chronic condition in Black and Hispanic adults and is a top risk factor for cardiovascular disease morbidity and mortality. Also, Black Veterans are more likely to die due to stroke compared to White Veterans in the VHA and controlling blood pressure is recognized a one of the most important ways to prevent stroke. Understanding the reasons for racial and ethnic differences in blood pressure treatment in Veterans is important for developing implementation plans that support high quality equitable care for all Veterans. This research is consistent with the VA Blueprint for Excellence Transformational Actions: “to understand and eliminate health inequalities.”

PI_NAMEs: MOHANTY, APRIL F (contact)

PROJECT_TERMS: Address;Adherence;Adult;Affect;Age;American;Anti-Hypertensive Agents;behavior change;Black race;Blood Pressure;blood pressure control;Blood Pressure Monitors;blood pressure reduction;blood treatment;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Caring;Chronic;chronic care model;Cities;Clinical;Clinical Practice Guideline;Color;Community Healthcare;comorbidity;dashboard;Data;Department of Defense;design;Diagnosis;disparities in morbidity;Disparity;disparity reduction;Enrollment;Ensure;Equity;ethnic difference;ethnic disparity;ethnic minority;Ethnic Origin;Evaluation;Evaluation Studies;Event;evidence base;Evidence based practice;experience;Feedback;follow-up;Frequencies;Geographic Locations;Goals;Guidelines;health equity;health inequalities;health management;Hispanic;Hypertension;hypertension control;hypertensive;implementation strategy;improved;Inequity;innovation;insight;Intervention;Interview;Judgment;Knowledge;Link;medical specialties;Medication Management;Methodology;Minority;modifiable risk;Morbidity - disease rate;mortality;mortality disparity;Patient Preferences;Patients;Performance;Pharmaceutical Preparations;pilot test;population health;Predictive Factor;Primary Care;prototype;Provider;Public Health;Race;racial difference;racial minority;Recommendation;Research;Risk Factors;Risk Reduction;Rural;sex;sociodemographics;Sodium Chloride;Stroke;Stroke prevention;Structure;Surgeon;Team Process;team-based care;Techniques;Testing;Theoretical Domains framework;tool;treatment disparity;Update;uptake;usability;Veterans;Veterans Health Administration;virtual healthcare;Visit

PROJECT_TITLE: Identifying and testing a tailored strategy to achieve equity in blood pressure control in PACT

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);Neurosciences;Pediatric;Social Determinants of Health;Substance Misuse

ORG_CITY: EL PASO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

PHR: Project Narrative The shortage of minority representation among scientists that conduct research and outreach in substance use disorders contributes to the lack of role models needed to train young students about the harmful impact of substance use, specifically in minority populations. With substance use disorders being prevalent among minority populations, it is of particular importance that we continue to foster the development of young minority students interested in pursuing careers in science. The UTEP (University of Texas El Paso) SMART MIND program is aimed at enhancing the education and research training of 12 undergraduate students, 3 high school teachers, and 6 high school students each summer (through Americans for Medical Progress), with a focus on neuroscience and public health issues related to substance use disorders.

PI_NAMEs: CANABA, KARINA C;ODELL, LAURA ELENA (contact);UMUCU, EMRE

PROGRAM_OFFICER_NAME: FRIEND, LINDSEY NICOLE

PROJECT_TERMS: Address;American;Area;Behavior;Behavioral;behavioral health;Behavioral Sciences;Biomedical Research;Brain;career;Categories;cohort;Communities;community college;community engaged research;cost;Development;Drug abuse;Drug Addiction;Educational Curriculum;Enrollment;experience;Exposure to;Faculty;faculty mentor;Female;Fostering;Foundations;Funding;Future;Goals;Health Disparities Research;health disparity;health disparity populations;high school;High School Faculty;High School Student;Hispanic;Hispanic Populations;interest;Knowledge;Learning;Medical;medical schools;member;Mentors;Methodology;Methods;Mexico;Minority;minority children;Minority Groups;minority student;Minority-Serving Institution;Molecular;Neurosciences;outreach;Participant;Persons;Phase;programs;Public Health;Recording of previous events;recruit;Reduce health disparities;Research;Research Personnel;Research Project Grants;Research Training;role model;Running;Science;Scientist;skills;Social Behavior;student mentoring;Students;substance use;Substance Use Disorder;success;summer program;teacher;Texas;Training;Training and Education;Training Programs;undergraduate student;Underrepresented Minority;Underrepresented Populations;Universities

PROJECT_TITLE: Summer Mentoring and Research in Transdisciplinary Methodologies in Neuroscience of Drug-Addiction (SMART MIND)


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_DEPT: PATHOLOGY

PHR: NARRATIVE Infertility is a significant health concern for 15% of the general population with the women representing approximately half of those cases. Defective oocyte development during the formation of the ovarian reserve likely contributes to infertility and changes to female reproductive lifespan. The goal of these studies is to determine how Gremlin-1 and Gremlin-2 direct somatic and germ cell development in the fetal mouse ovary using novel genetic models. 1

PI_NAMEs: PANGAS, STEPHANIE A. (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Adult;Affect;Aneuploidy;antagonist;Apoptosis;Architecture;Binding Proteins;Birth;Bone Morphogenetic Proteins;Cell Count;Cell Death;Cell Differentiation process;cell type;Cells;Data;Defect;design;Development;Disease;egg;Embryo;Embryonic Development;exhaustion;experimental study;extracellular;Family;Feedback;Female;Fertility;fetal;General Population;Genes;Genetic;Genetic Models;genetic variant;Germ Cells;Goals;Health;idiopathic infertility;Imaging Techniques;Infertility;Knock-out;Knockout Mice;Laboratories;Licensing;life span;Light;Mammals;Mediator;Meiosis;Menopause;Microscopy;Modeling;Molecular;Morphogenesis;morphogens;Mus;mutant;Mutant Strains Mice;Mutation;National Institute of Child Health and Human Development;novel;oocyte quality;Oocytes;Oogenesis;Optical Coherence Tomography;Ovarian;ovarian reserve;Ovary;Paracrine Communication;Pathologic;Pathology;Pathway interactions;Perinatal mortality demographics;Phenotype;Play;Population;primary ovarian insufficiency;Primordial Follicle;Proliferating;Protein Dynamics;protein function;Proteins;Regulatory Pathway;Reporter;Reproduction;reproductive;reproductive senescence;reproductive system disorder;Research;response;Role;Signal Pathway;Signal Transduction;Signaling Protein;single cell genomics;single cell sequencing;Smad Proteins;Somatic Cell;Specific qualifier value;Sterility;Strategic Planning;Structure of primordial sex cell;subfertility;Subgroup;Supporting Cell;Testing;Time;Tissues;transcriptome;Transforming Growth Factor beta;Transplantation;Woman

PROJECT_TITLE: Grem1 and Grem2 in embryonic ovary development

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Infectious Diseases;Lung;Pediatric;Precision Medicine;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Pediatric acute respiratory distress syndrome (PARDS) is a heterogeneous syndrome characterized by severe, refractory hypoxemia not explained by heart failure or fluid overload that affects 6% of children requiring invasive mechanical ventilation in the pediatric intensive care unit (PICU). More than 40% of children who die PARDS-related deaths are previously healthy, very young children and there are currently no targeted therapies to treat PARDS apart from supportive care. The goal of this project is to identify molecular pathways that contribute to prolonged acute hypoxemic respiratory failure to guide the development of personalized therapies to alleviate the sequelae of lung injury and reduce long-term morbidity and mortality of critically ill children with acute lung injury.

PI_NAMEs: GRUNWELL, JOCELYN REBECCA (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Acute;acute hypoxemic respiratory failure;Acute Lung Injury;Acute Respiratory Distress Syndrome;Acute respiratory failure;Affect;airway immune response;Apoptosis;arginase;Arginine;Asthma;Bacteria;Bacterial Pneumonia;Behavior;big data management;Biochemistry;Biological;Biological Assay;Biometry;Biostatistical Methods;California;career development;Categories;Cell Physiology;Cells;Cessation of life;Child;Childhood;Clinical;clinical phenotype;Clinical Research;Clinical Trials;Clinical Trials Design;co-infection;Collaborations;Complex;Complex Analysis;Critical Illness;Critically ill children;cytokine;Cytoplasmic Granules;Data;Development;Development Plans;Disease;Doctor of Philosophy;Endothelium;Environment;Epithelium;Exocytosis;experience;Exposure to;Fellowship;Fluid overload;Fostering;Foundations;Functional disorder;functional status;Funding;Gene Expression;Goals;Heart failure;Heterogeneity;high dimensionality;Hypoxemia;Hypoxemic Respiratory Failure;Immune;Immune checkpoint inhibitor;Immunity;Impairment;Influenza;Innate Immune Response;insight;Institution;interest;Interferons;Intubation;Link;Liquid substance;Lower Respiratory Tract Infection;lung injury;Macrophage;Mechanical ventilation;Mentored Clinical Scientist Development Program;Mentored Patient-Oriented Research Career Development Award;Mentorship;metabolomics;Methods;mimetics;Modeling;Molecular;Morbidity - disease rate;mortality;NADPH Oxidase;neutrophil;novel;Pathway interactions;Patients;Pediatric Acute Lung Injury;Pediatric Acute Respiratory Distress Syndrome;Pediatric Intensive Care Units;personalized care;personalized medicine;Pharmacotherapy;Phenotype;Physicians;Play;Postdoctoral Fellow;Pre-Clinical Model;precision medicine;Precision therapeutics;predict clinical outcome;primary outcome;Pulmonary Edema;Recovery;recruit;Refractory;Research;research and development;Research Design;Research Methodology;Resolution;Respiratory Burst;Respiratory Tract Infections;response;Risk;San Francisco;Scientist;secondary outcome;Secondary to;sound;Stimulus;Supportive care;Syndrome;T-Cell Proliferation;T-Lymphocyte;targeted treatment;Testing;Training;Translational Research;United States National Institutes of Health;Universities;Viral;Viral Pneumonia

PROJECT_TITLE: Airway Immune Response in Critically Ill Children-Precision Medicine in Children At Risk for Acute Respiratory Distress Syndrome

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative (relevance to public health) ALS is a fatal neurodegenerative disease that causes progressive motor dysfunction, paralysis, and ultimately death. The mechanism of this disease is incompletely understood. This proposal will investigate the role of protein arginine deiminase 2 (PAD2) and protein citrullination in ALS pathogenesis. The results will uncover new mechanisms and may open a new avenue for ALS therapy.

PI_NAMEs: XU, ZUOSHANG  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Alzheimer's Disease;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Animal Model;Area;Astrocytes;Atherosclerosis;Calcium;Cell Physiology;cell type;Central Nervous System;central nervous system injury;Cessation of life;Charge;citrullinated protein;Citrulline;Cytoskeleton;Dimensions;Disease;Disease Progression;DNA Sequence Alteration;early detection biomarkers;endoplasmic reticulum stress;Gene Expression;Human;Immune response;Impairment;Inflammation;Inflammatory;inhibitor;Investigation;Isoenzymes;Knowledge;link protein;Lupus;Malignant Neoplasms;Mammals;Membrane;mitochondrial dysfunction;Modeling;Modification;motor disorder;motor neuron degeneration;mouse model;Multiple Sclerosis;Mus;Muscle Weakness;mutant;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neurons;novel marker;novel therapeutics;Nucleic Acids;nucleocytoplasmic transport;Paralysed;Parkinson Disease;Pathogenesis;Pathologic;phenomenological models;Post-Translational Protein Processing;Prion Diseases;protein aggregation;protein function;protein structure;Protein-arginine deiminase;Proteins;Proteomics;Public Health;Reaction;Reactive Oxygen Species;Research;RNA Processing;Role;Signal Transduction;Site;Spinal Cord;Substrate Specificity;targeted treatment;Tissues;Toxic effect

PROJECT_TITLE: Protein Arginine Deiminase 2 (PAD2) and Protein Citrullination in ALS

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Patient Safety;Precision Medicine

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Patients widely vary in their beneficial and adverse effects to medications, with important clinical and public health consequences. This research focuses on how a person’s genetic makeup, drug-drug interactions and drug metabolizing enzymes located outside human liver influence variability in drug response. The results will help to identify patients at increased risk for drug adverse effects or for lack of clinical benefit, which is a key step towards personalized therapy by selecting the right dose or drug for each patient.

PI_NAMEs: DESTA, ZERUESENAY  (contact)

PROJECT_TERMS: Adverse drug effect;Adverse effects;Bupropion;Clinical;clinical phenotype;Complement;Complex;CYP1A2 gene;CYP2B6 gene;CYP2D6 gene;Development;Diameter;Diastolic blood pressure;differential expression;Dose;drug disposition;drug efficacy;Drug Exposure;Drug Interactions;Drug Kinetics;drug metabolism;efavirenz;Enzymes;Extrahepatic;Funding;Genetic;genetic makeup;Genetic Variation;genomic biomarker;Genomics;Genotype;Goals;Guidelines;healthy volunteer;Hepatic;Hepatic Tissue;HIV;Human;in silico;In Vitro;in vivo;Inherited;inter-individual variation;Intestines;Kidney;Kinetics;Knowledge;liquid chromatography mass spectrometry;Liver;liver metabolism;medication safety;Metabolic Pathway;Methadone;Methods;Microsomes;National Institute of General Medical Sciences;novel;Package Insert;Paper;Patients;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacotherapy;Positioning Attribute;precision drugs;Public Health;Publications;Pupil;Research;response;Risk;Role;Science;Selection for Treatments;Stereoisomer;Testing;Tissues;tizanidine;tool;Toxic effect;UGT1A1 gene;Variant;Work

PROJECT_TITLE: Genomic and drug-drug interaction mechanisms of interindividual variability in drug disposition

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: DAVIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Over the past two decades, vast amounts of genomic data have been generated in medical genomics to identify the genetic basis of human disease. This proposal describes a set of research projects that will help the field to understand the impact of environmental confounding in such studies and the evolutionary forces that shape human genomic and phenotypic variation.

PI_NAMEs: COOP, GRAHAM  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Automobile Driving;Biology;Data;DNA Sequence;Environmental Impact;Evolution;Gene Frequency;Genealogy;Genetic;genome wide association study;genome-wide;genomic data;genomic predictors;genomic variation;Genomics;Genotype;Goals;Human;human disease;Human Genetics;Link;Maps;Medical;migration;Modeling;Natural Selections;novel;novel strategies;Phenotype;Population;Population Genetics;Population Statistics;Recording of previous events;Research Project Grants;Role;Shapes;Signal Transduction;Structure;Time;tool;trait;Variant;Work

PROJECT_TITLE: The impact of natural selection and population structure on human genomic variation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Community-associated (CA) MRSA is a major health concern worldwide that causes significant morbidly and mortality in humans. This work will fill a critical gap in knowledge pertaining to how the peptidome contributes to CA-MRSA disease etiologies. The information gained from this work has the potential to discover new mechanisms of host-pathogen interactions and can lead to the rational design of anti-virulence based therapies. !

PI_NAMEs: GONZALEZ, DAVID J (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;Area;Bacteria;Binding;Biochemical;Biological Assay;Biological Process;Biology;cell type;Cells;Communities;Complex;Cytolysins;Data;Development;Discipline;Disease;Environment;Epithelium;Etiology;Genes;Genome;Genomics;Genus staphylococcus;Health;Homologous Gene;Host Defense;Human;human pathogen;In Vitro;in vivo;Infection;Infectious Skin Diseases;innovation;Keratin;Knowledge;Libraries;Lipoproteins;Mass Spectrum Analysis;methicillin resistant Staphylococcus aureus;Microbiology;Modeling;Molecular;mortality;multiple omics;Mus;mutant;novel;novel therapeutics;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Penetration;Peptides;Phenols;Play;Process;prohibitin;Proteins;Proteome;Proteomics;Publishing;PubMed;rational design;Research;Role;Serum;skin lesion;Staphylococcal Infections;Staphylococcus aureus;Structure;synthetic peptide;System;Targeted Toxins;Testing;Tissues;Transcript;Virulence;Virulence Factors;Work

PROJECT_TITLE: Contribution of the peptidome to CA-MRSA virulence

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]