NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE  While we have identified many disrupted genes that lead to retinal diseases, we often do not know how they cause the disease phenotypes. Understanding how a pathogenic mutation leads to disease is extremely important for prognosis, for developing effective treatments and for assessing likely response to treatment. In this application we focus on understanding the molecules/pathways that are activated or suppressed to lead to photoreceptor degeneration, hyperopia and fundus spotting phenotypes; phenotypes found in many genetic retinal diseases.

PI_NAMEs: NISHINA, PATSY M (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Ablation;Affect;Binding;Biochemical;Biological;causal variant;Cell Count;cell growth;cell injury;Cell Nucleus;Cell Physiology;Cell Size;Cells;Choroid;Clinical;Computing Methodologies;cytokine;Cytoskeletal Proteins;Cytoskeleton;Data;Development;Diet;Disease;Disease Outcome;Disease Pathway;disease phenotype;Disease Progression;DNA Sequence Alteration;Docosahexaenoic Acids;Down-Regulation;effective therapy;experimental study;Eye;Eye diseases;Functional disorder;Funding;Fundus;Gene Mutation;gene network;Genes;Genetic;Genetic Diseases;Genetic Heterogeneity;genomic data;Goals;Growth;Human;Hyperopia;Immune;immune activation;Immune response;Infiltration;Inflammatory;Inherited;Intervention;Laboratories;Lead;Link;Mediating;Microglia;migration;Modeling;Molecular;Molecular Profiling;monolayer;Morphology;mosaic;Mus;mutant;Mutant Strains Mice;Mutation;Nature;Nuclear;Pathogenicity;Pathology;Pathway interactions;Peripheral;pharmacologic;Phenotype;phenotypic data;phosphoproteomics;photoreceptor degeneration;Photoreceptors;Play;postnatal development;preservation;Process;Production;Prognosis;Proteomics;response;restoration;Retina;Retinal Degeneration;Retinal Diseases;Role;Sclera;single nucleus RNA-sequencing;Spottings;Structure;Structure of retinal pigment epithelium;Testing;therapeutic target;transcriptomics;Transgenic Organisms;treatment response;Work

PROJECT_TITLE: Retinal Disease: Molecular Basis and Pathophysiology

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: NEW ORLEANS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Narrative This project will investigate how obesity, a worldwide epidemic, promotes colonic tumorigenesis by stimulating LD dynamics reinforced through elevated acyltransferases (DGATs). It will demonstrate that targeting DGATs shuts down the regulatory mechanisms driving LDs growth and utilization, thereby attenuating obesity driven colonic tumorigenesis.

PI_NAMEs: SAVKOVIC, SUZANA D. (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Acyltransferase;Adipose tissue;Attenuated;Automobile Driving;Bioinformatics;Cell Cycle;cell growth;cell transformation;Cells;Colon;colon growth;colon tumorigenesis;Colonic inflammation;Colonic Neoplasms;Data;Development;diacylglycerol O-acyltransferase;Diagnostic;Disease;Disease Outcome;Disease Progression;effective therapy;Environment;Epidemic;Epithelium;Exhibits;Fatty acid glycerol esters;Feedback;FOXO3A gene;Genetic Transcription;Growth;High Fat Diet;Human;Immune;Individual;Inflammation;Inflammation Mediators;Inflammatory;insight;Interleukin-10;Intracellular Accumulation of Lipids;Investigation;Link;Lipase;lipid biosynthesis;Lipids;Lipolysis;Mediating;Mediator;member;Metabolic;Metabolic Pathway;Molecular;mouse model;Mus;Mutation;Normal tissue morphology;novel;Obese Mice;obese person;Obesity;Organelles;Overweight;Pathway interactions;patient population;Patients;pharmacologic;Pharmacological Treatment;PIK3CG gene;prevent;Process;progenitor;Publishing;Regulation;Signal Transduction;Solid;The Cancer Genome Atlas;Therapeutic;Tissues;Transcript;transcription factor;transcriptome;Triglycerides;tumor;Tumor stage;tumorigenesis;tumorigenic

PROJECT_TITLE: Regulation of DGAT - dependent lipogenesis in colonic epithelial growth

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: BOSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Parkinson’s Disease leads to loss of dopaminergic neurons and many of the genes linked to the disease play roles in organelle quality control. Here we explore the mechanisms of action of two disease genes – FBXO7 and PINK1 – in mitochondrial quality control using systematic cell biological and proteomic approaches.

PI_NAMEs: HARPER, JEFFREY W (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Address;Alleles;Autophagocytosis;Autophagosome;Biochemical;Biological;Biological Assay;Biotinylation;Cells;Chromosome Mapping;cohort;Collaborations;Complex;Coupled;CRISPR screen;Cytoplasm;Cytoprotection;Data;Disease;dopaminergic neuron;Electron Microscopy;embryonic stem cell;Engineering;Etiology;Excision;experimental study;F-Box Proteins;FBXO7 gene;Genes;Homeostasis;human embryonic stem cell;Individual;Induced Neurons;Knowledge;Link;member;Membrane;Membrane Proteins;Methods;Mitochondria;Mitochondrial DNA;Molecular;multicatalytic endopeptidase complex;mutant;Mutate;Mutation;novel;Organelles;Outer Mitochondrial Membrane;Parkinson Disease;particle;Pathway interactions;Patients;Phosphorylation;Physiological;PINK1 gene;Play;Protein Kinase;Proteins;Proteomics;Quality Control;receptor;recruit;Regulation;Reporter;Role;Series;Signal Transduction;Site;SKP Cullin F-Box Protein Ligases;stem cells;Synapses;System;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Visualization;Work

PROJECT_TITLE: Regulation of PINK1 and PARKIN-Dependent Mitophagy

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


NIH_SPENDING_CATS: Cancer;Clinical Research;Prostate Cancer;Urologic Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative The proposed research is relevant to public health because insights into the specific molecular mechanisms that control prostate cancer (CaP) progression are ultimately expected to provide the foundation to develop novel treatment options that are tailored to the events that underlie the lethal phenotype of CaP, a malignancy that causes more than 30,000 deaths annually in the US. Thus, the proposed research is relevant to the part of NIH's mission that pertains to developing fundamental knowledge that will help reduce the burdens of human cancer.

PI_NAMEs: HEEMERS, HANNELORE  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Adult;advanced prostate cancer;Affect;American;Behavior;Benign;Biological Assay;Biology;Bypass;cancer therapy;Cause of Death;Cell Count;Cell Cycle;Cell Cycle Progression;cell dedifferentiation;Cell division;cell growth;Cell Line;Cell Proliferation;Cells;Cellular biology;Cellular Morphology;Cessation of life;citron rho-interacting kinase;Clinical;Coupled;defined contribution;Development;Disease;Disease Progression;Epithelial Cells;Epithelium;Event;Foundations;Gene Expression;Genetic;Germ Lines;Goals;Growth;Human;improved;In Vitro;in vivo;Inhibition of Cell Proliferation;inhibitor;innovation;insight;kinase inhibitor;Knowledge;Laboratories;Ligation;loss of function;Malignant neoplasm of prostate;Malignant Neoplasms;Mammals;Mass Spectrum Analysis;Mediating;men;Metastatic Prostate Cancer;Mission;Mitotic;Modality;Molecular;Molecular Biology;mortality;mutational status;new therapeutic target;novel;Oncogenic;Outcome;overexpression;Patients;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;pluripotency;prevent;Proliferating;Prostate;prostate cancer cell;prostate cancer cell line;prostate cancer progression;Prostate Cancer therapy;protein expression;Protein Kinase;Protein Kinase Interaction;Protein-Serine-Threonine Kinases;Public Health;Research;Resistance;Role;Serine;Signal Transduction;standard of care;stem cells;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapy resistant;Tissues;Tumor Volume;tumorigenic;United States National Institutes of Health;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: A novel determinant of prostate cancer growth

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The development of an effective HIV vaccine remains a major challenge. The current proposal seeks to develop HIV envelope broadly neutralizing antibody (bnAb) B cell lineage-based vaccine strategy to induce protective bnAb responses by vaccination. An effective vaccine could be a powerful intervention to prevent new HIV infections, and thus the application is highly relevant to human health and welfare.

PI_NAMEs: ANDRABI, RAIEES AHMAD (contact);SHAW, GEORGE M

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: Address;Affinity;Antibodies;Antibody Affinity;Antibody Response;Antigens;Apical;Automobile Driving;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Biological Models;Biology;Cell Lineage;Consensus;cross reactivity;Development;Directed Molecular Evolution;Elements;Engineering;Epitopes;Exclusion;Exhibits;Failure;Genes;Germ Lines;Grant;Health;HIV;HIV envelope protein;HIV Infections;HIV vaccine;HIV-1;HIV-1 vaccine;Human;Immunization;Immunoglobulin Gene Rearrangement;Immunoglobulin Somatic Hypermutation;In Vitro;in vivo;Infection;Intervention;Laboratories;Light;Macaca mulatta;Methods;Molecular;Molecular Conformation;nanoparticle;neutralizing antibody;next generation sequencing;novel;novel strategies;Pan Genus;Peptides;Phase;Polishes;Polysaccharides;preclinical trial;prevent;Process;programs;Property;Proteins;Regimen;Research Design;response;Rhesus;Scheme;simian human immunodeficiency virus;Site;SIV;Structure;Surface;T cell response;Testing;Time;tool;Translating;Vaccination;vaccination strategy;Vaccine Design;vaccine evaluation;Vaccine Research;vaccine strategy;vaccine trial;vaccine-induced antibodies;Vaccines;Variant;virus envelope;Virus Replication;welfare;Work

PROJECT_TITLE: B cell lineage directed rational vaccine strategies based on CAP256SU Env-Ab coevolution

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health

ORG_CITY: CHESTNUT HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON COLLEGE

PHR: PROJECT NARRATIVE Residents in our nation’s public housing developments live in conditions of concentrated poverty, unhealthy and unstable housing and community contexts, and weak social and economic opportunities, all key social determinants of poor health. This mixed-methods study exploits a multi-arm natural experiment of public housing redevelopment to evaluate whether improving housing quality, limiting external displacement and creating mixed-income communities improve the physical, mental, and behavioral health of public housing residents. Results will provide key insights into burgeoning economic health disparities, and inform policies and practices targeting our most disadvantaged neighborhoods.

PI_NAMEs: COLEY, REBEKAH LEVINE (contact);TEIXEIRA, SAMANTHA

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Adult;Affect;Age;American;arm;behavioral health;Boston;Characteristics;Child;Clinical;Communities;community based research;Complex;Control Groups;Crime;Data;design;Development;Development Plans;development policy;Disease;Disparity;Economics;Effectiveness;Emotional;Engineering;Environment;environmental health disparity;Equation;Ethnic Origin;Evidence based intervention;experience;Exposure disparity;Funding;Gender;Health;Health Disparities Research;health disparity;health economics;Home;Household;Housing;housing instability;improved;Income;Individual;Inequality;Inequity;innovation;insight;Interview;Investments;Knowledge;knowledge base;life span;longitudinal human study;Longitudinal Studies;Measurement;Measures;Mediating;Mental Health;Methods;Modeling;Morbidity - disease rate;mortality;National Institute on Minority Health and Health Disparities;Natural experiment;neighborhood disadvantage;neighborhood safety;Neighborhoods;novel;older adult;Outcome;Pattern;Personal Satisfaction;Persons;physical conditioning;Physiological;Policies;Pollution;Poverty;preservation;Process;Psychologist;Public Housing;Qualifying;Quasi-experiment;Race;Random Allocation;residence;Resources;Respondent;response;segregation;service providers;Site;social;social determinants;social health determinants;Social isolation;Social Problems;Social Workers;Sorting;Source;Stress;stressor;Surveys;Techniques;Testing;treatment effect;Youth

PROJECT_TITLE: Targeting Health Disparities through Housing Redevelopment: A Natural Experiment of Housing Quality, Stability, and Economic Integration

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Clinical Research;Genetics

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Narrative The overall goal of this project is to establish and refine the association of genetic polymorphism of the human leukocyte antigen (HLA) complex with a wide variety of health traits and immune markers in a cohort of unprecedented size. Central to immunity and critically important for human health, HLA molecules are encoded by complex genetic systems with extraordinarily high levels of sequence and structural variation and complex expression patterns that has been linked to hundreds of diseases. We will leverage the wealth of existing genetic data collected by the National Marrow Donor Program (NMDP) to examine these associations in fine detail in hundreds of thousands of individuals in order to improve our understanding of the role of HLA in human health and immunity.

PI_NAMEs: HOLLENBACH, JILL ALLISON (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 6p21;Address;Alleles;Antibodies;Antibody Response;Antibody Specificity;antigen binding;Antigenic Variation;Antigens;Autoimmune;Autoimmune Diseases;Binding;Bioinformatics;Biological Assay;Bone Marrow;cohort;Complex;Consent;Cytomegalovirus;Data;Disease;disease phenotype;Electronic Mail;Elements;Genes;Genetic;Genetic Polymorphism;Genetic Variation;Genotype;Goals;Haplotypes;Health;Histocompatibility Antigens Class II;HLA Antigens;Human;Human Characteristics;Human Chromosomes;Human Genome;Immune;Immune system;Immunity;Immunologic Markers;improved;Individual;Infection;Laboratories;large datasets;Link;Malignant Neoplasms;Maps;Marrow;Measures;Mediating;Medical;Methods;novel;Patient Self-Report;Pattern;Peptides;Phage Display;pharmacologic;phenome;Phenotype;Population;prediction algorithm;programs;Proteins;Proteome;Recording of previous events;recruit;Registries;Resolution;Role;Sample Size;Sampling;seropositive;Serum;Single Nucleotide Polymorphism;Specificity;Surveys;System;Testing;Time;trait;United States;Variant;Viral;Viral Antigens;virome;volunteer;web interface;Writing

PROJECT_TITLE: The landscape of HLA mediated variation in health and immunity

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cancer;Genetics

ORG_CITY: OMAHA

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PHR: Project Narrative: BubR1 is a key regulator of genomic integrity through controlling the spindle assembly checkpoint and also suppresses the process of cellular senescence, thus it is a key factor regulating the interrelationship between cellular stress, cancer, and aging. Protein levels of BubR1 are lost following cell stress such as glucose deprivation and decline naturally during the aging process in a wide variety of tissues, which can be reversed by preventing its ubiquitin-mediated degradation by the deacetylase SIRT2, however the molecular mechanisms promoting ubiquitination of BubR1 during stress and with age remain elusive. In this proposal we will define the role of the E3 ubiquitin ligase SCF-TRCP1 in promoting BubR1 degradation under these conditions, which will provide the impetus to target BubR1 stabilization as a therapeutic strategy against age- related diseases.

PI_NAMEs: NORTH, BRIAN J. (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Acetylation;Acetyltransferase;Age;age acceleration;age related decline;Age related pathologies;age-related disease;Aging;aging process;aging related;Aneuploidy;animal old age;Binding;Biological;Cell Aging;Cell Physiology;Cell Survival;Cellular Stress;CHEK1 gene;CREBBP gene;Cullin Proteins;Cyclin D1;Deacetylase;deprivation;detection of nutrient;Disease;druggable target;Ensure;extend lifespan;F Box Domain;Fibroblasts;Genetic;genome integrity;Genome Stability;Genomic Instability;Glucose;Goals;Health;healthspan;Human;In Vitro;in vivo Model;life span;Link;Lysine;Malignant Neoplasms;Mammals;Mediating;Mitosis;Mitotic;Molecular;mouse model;Mus;Mutation;neoplastic cell;normal aging;novel therapeutic intervention;Nutrient;nutrient deprivation;Pathway interactions;Physiological;Post-Translational Regulation;Premature aging syndrome;prevent;Protein Acetylation;protein degradation;Proteins;Proteome;Proteomics;Regulation;response;Role;segregation;senescence;Signal Pathway;Signal Transduction;Signaling Protein;Stress;Testing;Therapeutic;Tissues;tumor progression;Tumor Suppressor Proteins;tumorigenesis;Ubiquitin;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Regulatory Mechanisms Governing BubR1 Protein Stability During Stress and Aging

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative – Public Health Relevance  The investigation to be conducted through the present research strategy aims to establish the histopathologic and pathophysiologic correlates of vestibular hypofunction induced by the common ototoxin, gentamicin. The primary objective is to determine the physiologic signatures of the functional decrements providing insight into strategies through which these conditions can be identified in suspected patients. The histopathologic correlates will identify the cellular components of the inner ear vestibular epithelia that are associated with these deficits and, therefore, potential targets of protective and rehabilitative strategies.

PI_NAMEs: HOFFMAN, LARRY F (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Address;Afferent Neurons;Ally;Animal Model;Animals;Antibodies;Apical;Architecture;Autoimmune;base;Behavior;behavior test;Behavior Therapy;Behavioral;Bilateral;calyx structure;Characteristics;Code;Contralateral;Crista ampullaris;Development;Docking;Dose;Electrophysiology (science);Epithelium;Exhibits;Foundations;Frequencies;General Population;Gentamicins;Hair Cells;Histologic;Immunohistochemistry;Incubated;insight;Investigation;Ipsilateral;K ATPase;Label;Laboratories;Labyrinth;Lesion;light microscopy;Lighting;Measures;Meta-Analysis;Microscopy;Morphology;Na(+)-K(+)-Exchanging ATPase;neural;Neurobiology;neurosensory;OTOF gene;ototoxin;Outcome;Pathologic;Patients;Peripheral;Phase;Phenotype;Physiological;postsynaptic;presynaptic;Prevalence;Production;public health relevance;Recovery;Rehabilitation therapy;Reproducibility;Research;Resolution;response;Response to stimulus physiology;ribbon synapse;Scanning;Sensory;Shapes;Specimen;Stimulus;Structure;Synapses;Synaptic Cleft;Testing;Time;Transmission Electron Microscopy;Tubulin;Type I Hair Cell;uptake;Utricle structure;Vestibular Diseases;Vestibular dysfunction;Vestibular epithelia;Vestibular function;Vestibular Function Tests;Vestibular inner ear;Vestibular Neuronitis;vestibular system;vestibulo-ocular reflex;Work

PROJECT_TITLE: Peripheral vestibular hypofunction and neurosensory coding

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Chronic Pain;Clinical Research;Osteoarthritis;Pain Research;Rehabilitation

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The proposed project focuses on carpometacarpal osteoarthritis (CMC OA), a painful degenerative disease that severely limits thumb function. The structure and function of thumb muscles and how those muscles influence the primary symptoms of CMC OA (pain and joint instability) will be examined. The results will enhance our understanding of the complex relationship between muscles, disease severity, and symptom severity, while also informing clinical interventions to improve the quality of life for individuals with CMC OA.

PI_NAMEs: NICHOLS, JENNIFER A. (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Absenteeism at work;Address;Adopted;Affect;analog;Anatomy;Area;Articular Range of Motion;biomechanical test;Biomechanics;Biometry;biopsychosocial;bone;Clinical;clinical care;Clinical Treatment;Clinical Trials;cohort;Compensation;Complex;Data;Data Set;Degenerative Disorder;Degenerative polyarthritis;design;Disease;effective therapy;Electromyography;Electronics;Equilibrium;Excision;exercise intervention;experimental study;Fascicle;Future;Goals;Hand;Hand functions;Household;improved;in vivo;Individual;Intervention;Joint Instability;Joint repair;Joints;kinematics;Kinetics;Knowledge;Length;Ligaments;Measurement;Measures;Mechanics;Motor;Movement;Muscle;Muscle Contraction;Muscle function;muscular structure;Musculoskeletal;Musculoskeletal Pain;novel;Operative Surgical Procedures;Orthopedics;Pain;Pain Measurement;pain relief;Pain Research;Patient Self-Report;Pattern;Play;Postoperative Period;Quality of life;reconstruction;Research;Research Methodology;Role;Sensory;Severities;Severity of illness;simulation;soft tissue;Standardization;strength training;Structure;Symptoms;Techniques;Testing;therapy design;Thumb structure;Time;Ultrasonography;ultrasound;Uninsured Medical Expense;Visual;Wages

PROJECT_TITLE: Carpometacarpal Osteoarthritis: Understanding the Intersection of Muscle Mechanics, Joint Instability, and Pain

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: IRVINE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Telomeres are closely involved in stem cell differentiation and cancer cell proliferation. The results of this study will lead to new mechanistic principles of telomere length homeostasis and chromosome stability in cells. Therefore, valuable targets for mechanism-driven design of anti-premature aging and cancer therapeutics may be identified through this research.

PI_NAMEs: QIAO, FENG  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;aging related disease;Biochemical;Biogenesis;cancer cell;Cell Proliferation;Cells;Chromosomal Stability;Chromosomes;Complex;Degenerative Disorder;design;Development;Disease;DNA;Ensure;Fission Yeast;Foundations;Functional disorder;genome integrity;Homeostasis;Individual;insight;Investigation;Length;Link;Maintenance;Malignant Neoplasms;Molecular;Mutation;National Institute of General Medical Sciences;novel therapeutic intervention;Play;Positioning Attribute;Premature aging syndrome;Process;programs;Proliferating;Quality Control;Research;Resolution;RNA Folding;Role;stem cell differentiation;Structure;success;Telomerase;Telomerase RNA Component;telomere;Therapeutic;X-Ray Crystallography

PROJECT_TITLE: Molecular Mechanisms of Telomere Length Homeostasis

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Liver Disease;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Differentiation is a fundamental process evident in a variety of cell states and transitions. Differentiation is a common feature in tumors, which is most pronounced in colorectal cancer, a vexing health problem. We seek to elucidate how LIN28B, an mRNA binding protein, fosters differentiation in colorectal cancers and concurrently, promote metastasis in this differentiated state.

PI_NAMEs: RUSTGI, ANIL K (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Address;Admixture;adult stem cell;Attenuated;Bar Codes;Binding Proteins;cancer site;Cell Cycle;Cell Differentiation process;cell growth regulation;Cell Physiology;Cell-Cell Adhesion;Cells;Cellular Metabolic Process;Circulation;Classification;claudin-1 protein;colon cancer cell line;Colon Carcinoma;Colonic Adenoma;Colorectal Cancer;Complex;Data;Dependence;Development;Distant;Embryo;embryonic stem cell;Endowment;Equilibrium;Extravasation;Fostering;gain of function;Gene Expression;Genetic;Genetic Engineering;Health;Homeostasis;Human;Human Engineering;Hybrids;Implant;in vivo;induced pluripotent stem cell;Injections;innovation;insight;intestinal epithelium;Invaded;knock-down;Liver;loss of function;Maintenance;Malignant - descriptor;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mediating;Messenger RNA;metastatic colorectal;Metastatic Neoplasm to the Liver;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Neoplasm Metastasis;neoplastic cell;NOTCH3 gene;novel;novel marker;Oncogenic;Organ;Outcome;overexpression;pharmacologic;Phenotype;Physiological;Play;pluripotency;pluripotent stem cell differentiation;Portal vein structure;Process;programs;Proliferating;Property;Publishing;regeneration following injury;Regulation;RNA-Binding Proteins;Role;Scheme;Signal Transduction;single-cell RNA sequencing;stem cell differentiation;stem cell division;Therapeutic;Tight Junctions;Totipotency;TP53 gene;transcription factor CDX2;transcriptome sequencing;tumor;Tumor Cell Invasion;tumor heterogeneity;tumor progression;tumorigenesis

PROJECT_TITLE: LIN28B promotes colorectal cancer differentiation and metastasis

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative  Clostridioides difficile is a toxin-producing bacterium that is a frequent cause of hospital-acquired and antibiotic-associated diarrhea. The United States Centers for Disease Control reports that in 2017, there were 223,900 estimated cases of C. difficile infection (CDI) in hospitalized patients with an estimated 12,800 deaths in the United States. This project will define the mechanism of how the toxin engages receptor proteins on the host cell surface and thus, provide a framework for advancing novel therapeutic and CDI prevention strategies.

PI_NAMEs: LACY, DANA BORDEN (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Anaerobic Bacteria;Animals;antibiotic-associated diarrhea;Apical;Apoptosis;Avidity;Bacteria;Binding;Binding Sites;Brush Border;Cell Line;Cell model;Cell surface;cell type;Cells;Cellular Tropism;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chondroitin Sulfate Proteoglycan;Clinical;Clostridium difficile;Colon;Communities;Complex;Cryoelectron Microscopy;cytokine;Data;design;Development;Diarrhea;Disease;Enzymes;Epidemic;Epithelium;Etiology;experience;experimental study;Family;Funding;FZD1 gene;Glucosyltransferase;Goals;Guanosine Triphosphate Phosphohydrolases;Hospitalization;Hospitals;Human;human disease;in vivo;Incidence;Infection;Infection prevention;Inflammation;intestinal crypt;Intestines;Intoxication;Life;light microscopy;Link;Location;Mediating;member;microscopic imaging;Modeling;Molecular;molecular imaging;mouse model;Mus;Mutagenesis;mutant;Mutation;nectin;novel;novel therapeutics;Pathogenesis;Patients;PDGF receptor tyrosine kinase;Persons;Physiological;Platelet-Derived Growth Factor Receptor;Play;poliovirus receptor;predictive tools;Prevention;Prevention strategy;Production;programs;Proteins;Pseudomembranous Colitis;Public Health;receptor;receptor binding;receptor function;recurrent infection;Reporting;Reproduction spores;Research;Resolution;response;rho;Ribotypes;Role;Site-Directed Mutagenesis;Stromal Cells;structural biology;Structure;Surface;Symptoms;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Intervention;Tissue Model;Tissues;Toxic Megacolon;Toxin;Tropism;United States;Vaccines;Variant;Villus;Virulence Factors;Work

PROJECT_TITLE: Structural Mechanisms of Clostridioides difficile pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Y(02)M]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Digestive Diseases;Heart Disease;Microbiome;Nutrition;Obesity;Prevention

ORG_CITY: MILWAUKEE

ORG_DEPT: SURGERY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative Heart failure with preserved ejection fraction is closely associated with obesity, with no treatment known to decrease cardiovascular mortality. Bariatric surgery is a promising treatment for obesity-associated heart failure with post-operative improvements in heart function. This project will lead to an understanding of how bariatric surgery improves heart function in patients with obesity-related heart failure and lead to the development of new surgical and non-surgical therapies for this disease.

PI_NAMEs: KINDEL, TAMMY LYN (contact)

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: Affect;Agonist;Anatomy;Animal Model;Anti-Inflammatory Agents;Antioxidants;Bacteria;bariatric surgery;beta diversity;Bile Acids;Body Weight decreased;Caloric Restriction;Cardiac;Cardiac Myocytes;Cardiovascular system;Cell Line;Data;Development;dietary restriction;dieting;Disease;EFRAC;Engineering;Feces;Functional disorder;Gastrectomy;gastrointestinal;Gene Expression;Genetic;Goals;gut microbes;gut microbiome;gut microbiota;Heart;Heart failure;heart function;Human;Impairment;improved;In Vitro;in vivo;Inflammation;Intervention;Knockout Mice;Lead;Measures;Mediating;Medical;Metabolic;Metabolic stress;Metagenomics;microbial;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Muscle Cells;novel;Nuclear;Obese Mice;obese patients;Obesity;obesity treatment;Operative Surgical Procedures;Physiological;Plasma;Pluripotent Stem Cells;Postoperative Period;preservation;receptor;Receptor Activation;receptor expression;Receptor Gene;Receptor Signaling;Recovery;Rodent;Sequence Analysis;Signal Transduction;Techniques;Testing;Ventricular

PROJECT_TITLE: Identifying Gut Microbiome Mediated Mechanisms for Diastolic Dysfunction Improvement After Bariatric Surgery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative A subset of B-cell acute lymphoblastic leukemia (B-ALL) patients will relapse and succumb to treatment- resistant disease. We found that B-ALL remodels the microenvironment around the leukemia to alter monocyte differentiation, with a subpopulation of nonclassical monocytes that both predicts pediatric and adult B-ALL patient survival and supports B-ALL progression and treatment evasion. The goal of this project is to determine the precise function of leukemia-associated nonclassical monocytes in supporting B-ALL survival and establish new immune-based therapeutic approaches that improve the efficacy of conventional B-ALL therapies, which reflects the public health relevance of this project.

PI_NAMEs: WITKOWSKI, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: 3-Dimensional;Ablation;Acute leukemia;Adult Precursor B Lymphoblastic Leukemia;Animal Model;Award;B-Cell Acute Lymphoblastic Leukemia;B-cell precursor acute lymphoblastic leukemia cell;B-Lymphocyte Subsets;Behavior;behavioral study;Bioinformatics;Biological;Biological Markers;Biology;Blood Vessels;Bone Marrow;cancer therapy;career development;CD14 gene;Cells;Chemoprotective Agent;chemotherapy;Childhood;Childhood Leukemia;Childhood Precursor B Lymphoblastic Leukemia;Clinical;Clinical Trials;cohort;Collaborations;Combined Modality Therapy;Data;Development;Development Plans;Devices;Diagnosis;Disease;Disease Progression;Disease remission;Disease Resistance;early phase clinical trial;effectiveness evaluation;Emergency Situation;Endothelium;Epigenetic Process;experience;Experimental Leukemia;Failure;FCGR3B gene;first responder;Fostering;Foundations;Genetic;Goals;Human;Image;Immune;Immunology;Immunotherapeutic agent;Immunotherapy;improved;in vivo;inhibitor;Knowledge;Laboratories;leukemia;Leukemia Acute Lymphoblastic Chemotherapy;leukemia treatment;Macrophage Colony-Stimulating Factor;Macrophage Colony-Stimulating Factor Receptor;Maintenance;Manuscripts;Maps;Microfluidics;Modeling;monocyte;mouse model;Mus;Myelogenous;Myeloid Cells;neoplastic cell;patient response;Patient-Focused Outcomes;Patients;Pediatric Hospitals;Play;Population;Postdoctoral Fellow;pre-clinical;Preparation;programs;public health relevance;Receptor Inhibition;Relapse;Remission Induction Therapy;repaired;Reporter;Research;research and development;Research Personnel;Resistance;Resolution;response;Role;Sampling;Specimen;Suggestion;Testing;Texas;Therapeutic;therapy resistant;Training;Transition Career Development Award (K22);Treatment outcome;Treatment Protocols;treatment response;tumor;tumor-immune system interactions;two photon microscopy;two-photon;United States National Institutes of Health;Universities;Vascular Endothelial Cell;Vascular Endothelium;Vascularization;Visualization;Work;Xenograft procedure

PROJECT_TITLE: Dissecting the Functional Role of Monocytes in B-cell Acute Lymphoblastic Leukemia Survival


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Cannabinoid Research;Endocannabinoid System Research;Genetics;Mental Health;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE While conventionally seen as restricted to axon initial segments, recent evidence has implicated Ankyrin-G and Ankyrin-B in the biology of central nervous system glutamatergic synapses. However, little is known about their postsynaptic roles. Here, building on our progress made during the previous funding period, we will investigate the functions of ankyrins and their protein partners at cortical glutamatergic synapses, cortical circuits, and behaviors controlled by the frontal cortex.

PI_NAMEs: PENZES, PETER  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: ANK2 gene;ANK3 gene;Ankyrin Repeat;Ankyrins;autism spectrum disorder;Axon;Behavior;Behavioral;Biochemical;Bioinformatics;Biological Process;Biology;Bipolar Disorder;Brain;Brain Diseases;Calcium;Cell membrane;cell type;Cellular biology;Central Nervous System;Complex;conditional knockout;Data;Dendrites;Deubiquitination;Development;endocannabinoid signaling;exome sequencing;Family Study;frontal lobe;Funding;Funding Opportunities;Future;Genes;Genome;genome-wide;Glutamates;GTP-Binding Proteins;Homer 1;Human;Hybrids;Image;In Vitro;in vivo;Intellectual functioning disability;Knock-out;Knockout Mice;Laboratories;Maintenance;Methods;Molecular Biology;Morphology;mouse model;Mus;Mutation;Neurobiology;Neurodevelopmental Disorder;Neurons;neuroproteomics;neuropsychiatric disorder;novel;palmitoylation;Pathogenicity;Pattern;Phenotype;Plasmids;Play;Positioning Attribute;postsynaptic;Process;Proteins;Proteomics;rare variant;Reagent;Regulation;Reporter;Research;risk variant;Rodent;Role;scaffold;Schizophrenia;Site;spatiotemporal;Structure;Susceptibility Gene;Synapses;synaptic function;Synaptosomes;Testing;Time;Transforming Growth Factor beta;two photon microscopy;ubiquitin isopeptidase;ultra high resolution;United States National Institutes of Health;Variant;Vertebral column;Yeasts

PROJECT_TITLE: Postsynaptic roles of ankyrins

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Precision Medicine;Psychosis

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE We will develop novel tools for modeling personalized functional networks and predicting psychopathology in youth.

PI_NAMEs: FAN, YONG  (contact);SATTERTHWAITE, THEODORE

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Acceleration;Address;Adolescent;Adopted;Adoption;analytical tool;Anxiety;Architecture;Attention deficit hyperactivity disorder;Award;Brain;Brain imaging;Clinical Data;cognitive development;cohort;Communication;Communities;computational platform;Computer software;Computing Methodologies;connectome;Data;Data Analyses;data harmonization;Data Set;data structure;deep learning;deep learning algorithm;deep neural network;Development;Diagnostic;Dimensions;Engineering;Ensure;Environment;Functional Magnetic Resonance Imaging;Future;Human;human data;Image;image processing;improved;Individual;integration site;interest;large scale data;Learning;Magnetic Resonance Imaging;Measurement;Measures;Mental Depression;Methods;model building;Modeling;multiple datasets;mutual learning;Nature;network architecture;network models;neural;neural network architecture;neuroimaging;Neurons;neuropsychiatry;Neurosciences;novel;novel diagnostics;open source;outcome prediction;Paper;Pennsylvania;personalized medicine;Persons;Philadelphia;portability;predictive modeling;Procedures;programs;psychiatric symptom;Psychopathology;Psychoses;recurrent neural network;Reproducibility;Research;self supervised learning;Site;Source Code;Statistical Models;success;Symptoms;System;Techniques;tool;translational potential;translational scientist;Universities;user-friendly;Work;Youth

PROJECT_TITLE: Personalized Functional Network Modeling to Characterize and Predict Psychopathology in Youth

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Unlike mammals, zebrafish possess the ability to regenerate entire appendages following traumatic injury, such as amputation, and these regenerated appendages faithfully recapitulate the size and shape of the original appendage. How size and shape are encoded during appendage regeneration in unclear, in part because there is an incomplete dynamic and quantitative understanding of the cellular events that underlie regeneration. This proposal will quantitatively define the dynamic molecular and cellular events that promote zebrafish appendage regeneration and uncover molecular events that are potential therapeutic targets for enhancing appendage regeneration in humans.

PI_NAMEs: BAKER, ASHLEY RICH (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Address;Amputation;appendage;Biological Assay;Biological Process;Biosensor;Body Size;bone;bone fracture repair;Bone Matrix;Bone Regeneration;Cell Differentiation process;Cell Proliferation;Cells;Computing Methodologies;Data;desensitization;Development;digit regeneration;Dissection;Environment;Event;Exhibits;experimental study;Extracellular Signal Regulated Kinases;Feedback;Genetic;Goals;Growth;Growth Factor;Hour;Human;Hypertrophy;Image;imaging modality;imaging platform;Individual;injured;Injury;insight;Lateral;Length;Ligands;Mammals;Maps;Medial;Mentorship;Mesenchymal;migration;Modeling;Molecular;molecular dynamics;Natural regeneration;Nature;novel;optogenetics;osteoblast differentiation;Osteoblasts;Pathway interactions;Pattern;pharmacologic;Process;Proliferating;regenerative;regenerative biology;Research;Resolution;Role;Shapes;Signal Pathway;Signal Transduction;spatiotemporal;Structure;System;Testing;therapeutic target;Time;tissue regeneration;Tissues;Training;Traumatic Amputation;Traumatic injury;Travel;Universities;Work;Writing;Zebrafish

PROJECT_TITLE: Quantitative dissection of the events that encode bone size and shape during regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Nanotechnology;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: PORTLAND

ORG_DEPT: DENTISTRY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE This project seeks to develop bone scaffolds that are biomimetically mineralized on the nanoscale and both vascularized and innervated prior to implantation. Several aspects that are of central importance to the success of developing bone scaffolds with close similarities to natural bone will be addressed, including the conditions required to induce osteogenesis in cell-loaded bone-like hydrogels, and the optimal conditions at which bone marrow mesenchymal stem cells differentiate into pericyte-like cells to form mature vascular capillaries and neuronal networks. We contend that the results of this project will enable development of regenerative strategies with improved clinical outcomes for bone augmentation.

PI_NAMEs: BERTASSONI, LUIZ EDUARDO (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 3-Dimensional;3D Print;Address;Autologous;Autologous Transplantation;Biocompatible Materials;Biological;Biological Models;Biomanufacturing;Biomimetics;biomineralization;Blood capillaries;Blood flow;Blood Vessels;bone;bone engineering;bone marrow mesenchymal stem cell;Bone Matrix;Bone Regeneration;bone repair;bone scaffold;Bone structure;Bone Substitutes;Bone Tissue;Bone Transplantation;calcification;Calvaria;Cells;Cementation;Characteristics;Clinic;Clinical;clinical application;Communication;cost;Defect;design;Development;endothelial stem cell;Engineering;Excision;extracellular;Failure;Future;Gel;Harvest;Hospital Costs;human stem cells;Hydrogels;Impairment;Implant;implantation;improved;In Vitro;in vitro regeneration;in vivo;in vivo regeneration;Injectable;innovation;long bone;Malignant Neoplasms;manufacture;manufacturing process;Mesenchymal Stem Cells;Methods;Microfluidic Microchips;Microfluidics;mineralization;Minerals;Morbidity - disease rate;nano;nanoengineering;nanoscale;Nanostructures;Natural regeneration;Nerve Fibers;nerve stem cell;nerve supply;Nervous System;Neurons;novel;Operative Surgical Procedures;Oral;Osteogenesis;osteogenic;osteoprogenitor cell;Outcome;Paracrine Communication;Pericytes;Phenotype;physical property;Physiologic calcification;Play;Procedures;Process;Property;regeneration potential;regenerative;regenerative approach;Regenerative capacity;response;scaffold;scale up;Series;Site;skeletal;stem cell differentiation;stem cells;Structure;success;System;Testing;Time;Tissue constructs;Tissue Donors;Tissue Engineering;Tissues;tool;Trauma;Vascular blood supply;Vascularization;virtual;Work

PROJECT_TITLE: Microengineering vascularized and innervated bone-like scaffolds as an alternative to autologous bone grafts

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Neurosciences;Women's Health Research

ORG_CITY: RICHARDSON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: PROJECT NARRATIVE Maternal behavior is impaired under conditions of chronic stress and/or adversity as well as in postpartum mood disorders. This application will examine the impact of postpartum adversity (as modeled through environmental resource depletion) on motivated maternal behaviors and mesolimbic dopamine function in the rat dam by employing an integrated approach (e.g. environmental perturbation, behavior, in vivo electrophysiology, optical recordings of genetically identified cells via the use of transgenic animals and in vivo fiber photometry, circuit- specific manipulations using DREADDs). In this way, I hope to provide insights into mesolimbic DA mechanisms contributing to adversity-induced alterations in mother-infant attachment.

PI_NAMEs: RINCON CORTES, MILLIE  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Address;Advisory Committees;Affective;Amygdaloid structure;Anhedonia;Attenuated;attenuation;Automobile Driving;awake;Award;Beds;Behavior;Behavioral;Behavioral Assay;career;Caring;cell type;Cells;Childbirth;Chronic;Chronic stress;coping;Corticosterone;Data;designer receptors exclusively activated by designer drugs;Development;Dopamine;dopamine system;dopaminergic neuron;Down-Regulation;Electrophysiology (science);Environment;Event;Exhibits;experience;experimental study;Exposure to;Female;Fiber;Functional disorder;Future;Genetic;genetic approach;Globus Pallidus;Goals;Hormonal;Hormones;Human;Hyperactivity;Impairment;improved;in vivo;Induced Neurons;Infant;insight;interest;Knowledge;Link;male;maltreatment;Maternal Behavior;Measurement;Mediating;Mediator;Mental Depression;Mental Health;Mentors;mesolimbic system;Metyrapone;Mission;Modeling;Mood Disorders;Moods;motherhood;Mothers;Motivation;National Institute of Mental Health;negative affect;neglect;neural circuit;Neural Pathways;neuromechanism;Optics;Ovarian;Pathway interactions;pharmacologic;Pharmacology;Photometry;Population;Postpartum Depression;Postpartum Period;Process;pup;Pyramidal Cells;Rat Transgene;Rattus;Regulation;Research;Resources;response;Retrieval;Rewards;Risk;Risk Factors;Rodent;Rodent Model;Role;skills;social;Stress;Structure;Symptoms;System;Testing;Time;Transgenic Animals;Ventral Tegmental Area;Withdrawal;Woman;Work

PROJECT_TITLE: Environmental modulation of maternal behavior and mesolimbic DA function

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Understanding the aberrant hormonal and genetic regulation of cellular homeostasis is the key to unraveling chronic and emerging disease and to develop new treatment strategies. The major goal of this project is to provide medical students who have completed at least one year of medical school with a hands-on summer research experience in NIDDK-focused research on endocrine-related health concerns to stimulate their interest in a clinical-research career.

PI_NAMEs: KLINGE, CAROLYN M. (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Authorship;Cardiovascular system;career;Clinical;Complications of Diabetes Mellitus;Conflict of Interest;Data;Diabetes Mellitus;Diabetic Nephropathy;disadvantaged background;Education;Educational Curriculum;Endocrine;Endocrinology;Environment;experience;fabrication;faculty mentor;faculty research;Funding;Goals;hormone regulation;human subject;IACUC;Institutional Review Boards;International;Journals;Laboratories;Malignant Neoplasms;medical schools;Medical Students;meetings;Mentors;Mentorship;Metabolism;Methods;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver disease;Obesity;Outcome;peer;Peer Review;peptide hormone;Persons;Physicians;Pituitary Gland;Plagiarism;posters;programs;Publications;Publishing;Regulation;Reproducibility;Research;Research Personnel;Research Project Grants;Research Training;responsible research conduct;Scholars Program;Scientist;skills;stem cell biology;Structure;Student recruitment;Students;summer research;summer student;Training;Training Programs;Training Support;Translational Research;underrepresented minority student;Universities;Vertebrates;Work

PROJECT_TITLE: Summer Endocrine Research Training Program

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Narrative: Hepatic ischemia-reperfusion injury (IRI) occurs following liver surgery or transplantation. The mitochondria play a central role in IRI through the regulation of metabolism as well as death signaling events. The proposed research will dissect the molecular signaling events associated with the maintenance of a functional mitochondrial pool in the context of IRI.

PI_NAMEs: TOMAR, DHANENDRA  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Ablation;Architecture;Automobile Driving;Autophagosome;Binding;Bioenergetics;Biogenesis;Biology;Calcium;career;Cell Death;Cell membrane;Cell Survival;Cells;Cessation of life;Complex;Coupled;Data;Development;EF Hand Motifs;EF-Hand Domain;Endoplasmic Reticulum;Equilibrium;Event;Generations;Genetic;Genetic Models;Hepatic;hepatic necrosis;Hepatocyte;Homeostasis;hormone regulation;Impairment;In Vitro;in vivo;ischemic injury;Knock-in;Knock-in Mouse;Link;Lipids;live cell imaging;Liver;liver injury;liver ischemia;Maintenance;Mediating;Membrane;Membrane Potentials;Membrane Proteins;Metabolism;Mitochondria;mitochondrial membrane;mitochondrial permeability transition pore;Mitochondrial Swelling;Molecular;mouse model;Mus;Mutation;Necrosis;Necrosis Induction;novel;novel therapeutic intervention;Nutrient availability;Operative Surgical Procedures;Organ failure;Organelles;Outer Mitochondrial Membrane;Output;Oxidation-Reduction;Pathogenicity;Physiological;Physiological Processes;Play;Positioning Attribute;Post-Translational Protein Processing;Process;programs;Protein Biochemistry;Proteins;Recycling;Regulation;Reperfusion Injury;Reporter;Reporting;Research;Resistance;response;rho GTP-Binding Proteins;Role;Rupture;Shapes;Signal Pathway;Signal Transduction;skills;spheroids;Stress;Structure;System;Testing;Tissues;tool;trafficking;Transplantation;Ubiquitin;uptake

PROJECT_TITLE: Impact of mitochondrial structure on cellular homeostasis and hepatic injury

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Patient Safety;Precision Medicine;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE The HIV epidemic in U.S. women disproportionately affects women of color; 61% of HIV-infected women are African-American and 19% are Hispanic/Latina; the population is also rapidly aging, with 70% of U.S. HIV patients predicted to be ≥50 years by 2030. Women and older patients may be at increased risk of adverse events, at least partly due to differences in drug clearance. This study aims to quantify these differences, using MACS/WIHS Combined Cohort Study participants receiving integrase-inhibitor or tenofovir alafenamide-based antiretroviral regimens.

PI_NAMEs: DUMOND, JULIE BRUMER (contact)

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adult;Adverse drug event;Adverse effects;Adverse event;adverse event risk;African American Women;Age;age difference;age effect;Aging;aging related;Analytical Chemistry;Anti-Retroviral Agents;antiretroviral therapy;Automobile Driving;base;Biological Aging;Biological Markers;Biological Specimen Banks;Body Weight;Categories;CD4 Positive T Lymphocytes;Cell Count;Cells;Characteristics;Clinical;Clinical effectiveness;Clinical Pharmacology;Clinical Trials;cohort;Cohort Studies;Complex;Data;diagnostic tool;Disproportionately impacts women;Drug Approval;drug clearance;Drug Evaluation;Drug Exposure;Drug Kinetics;Drug Modelings;Enrollment;Epidemic;ethnic diversity;evidence base;evidence based guidelines;experience;Exposure to;Female;frailty;Genetic;Goals;high risk;Hispanic;HIV;HIV-1;Hormonal;Hour;Immunologics;improved;Incidence;individual variation;inhibitor;Insulin Resistance;Integrase;Integrase Inhibitors;interest;Investigation;Knowledge;Laboratories;Latina;Measures;men;Metabolic;Methods;Modeling;Morbidity - disease rate;mortality;older patient;Older Population;Outcome;Participant;patient subsets;Patients;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;pharmacodynamic model;pharmacogenetic variants;Pharmacogenetics;Pharmacogenomics;pharmacokinetic model;pharmacokinetics and pharmacodynamics;Phase;Phase III Clinical Trials;Phenotype;Plasma;Population;Population Heterogeneity;precision medicine;prospective;Recovery;Regimen;Research;response;Risk;Risk Factors;RNA;Sampling;sex;Site;socioeconomics;Specimen;Tenofovir;Testing;tool;Toxic effect;treatment response;Validation;Viral;Visit;Waist-Hip Ratio;Weight Gain;Woman;women of color;women patients;Work

PROJECT_TITLE: Quantifying Sex-and-Age-Related Differences in Antiretroviral Exposure and Adverse Effects in the MACS/WIHS Combined Cohort Study

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Infant Mortality;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Stroke;Unintentional Childhood Injury

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative While MRI is the most effective tool for assessing neonatal brain disease and injury, the size and siting constraints of conventional scanners requires the transfer of patients to a centralized radiology suite for imaging. For unstable newborns with brain injury, there are significant risks associated with this transfer that often preclude MRI imaging. Our goal is to address this with a novel, newborn-sized brain MRI scanner designed for operation at the bedside in neonatal ICUs with minimal patient disturbance.

PI_NAMEs: COOLEY, CLARISSA ZIMMERMAN (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Acoustics;Address;Air;Architecture;Assessment tool;attenuation;Beds;Birth;Brain;Brain Diseases;Brain imaging;Brain Injuries;brain magnetic resonance imaging;Brain Pathology;brain size;Caring;Cephalic;Congenital Abnormality;cost;Dangerousness;Dedications;design;Detection;detector;Developing Countries;Development;Diagnosis;Diffusion;diffusion weighted;disability;Early Diagnosis;Early identification;Early Intervention;Electromagnetics;Environment;Equipment;Excision;Future;Gel;Genetic Programming;Goals;Head;Hemorrhage;Hour;Hydrocephalus;Image;image reconstruction;Imaging Techniques;improved;Infant;instrument;Intervention;Ionizing radiation;Lead;Life;Live Birth;magnetic field;Magnetic Resonance Imaging;Methods;Monitor;Morphologic artifacts;natural hypothermia;Nature;Neonatal;neonatal brain;neonatal care;neonatal hypoxic-ischemic brain injury;Neonatal Intensive Care Units;neonatal magnetic resonance imaging;neonatal morbidity;Neonatal Mortality;neonate;neural;Neurodevelopmental Disability;Newborn Infant;Noise;novel;operation;Patient Care;patient population;Patient Transfer;Patients;Peripheral;Phase;point of care;point-of-care diagnostics;portability;Positioning Attribute;preterm newborn;Property;Radiology Specialty;recruit;RF coil;Risk;Safety;Scanning;Seizures;soft tissue;Speed;Staging;standard care;standard of care;Stress;Survival Rate;Survivors;System;Technology;Tissues;ultrasound

PROJECT_TITLE: Portable MRI Technology for Neonatal Care

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative A critical barrier to controlling tuberculosis (TB) is the estimated 40% of TB cases who remain undiagnosed, infectious, often without TB symptoms (subclinical) fueling TB transmission. Finding these missing TB cases is challenging and necessary for halting transmission in the fight against TB. We propose to determine whether missing cases could be effectively and efficiently found in areas where TB transmission is concentrated, using innovative spatial and pathogen transmission modeling and use of novel diagnostics to detect infectious forms of TB that include subclinical TB.

PI_NAMEs: MATHEMA, BARUN  (contact);NAIDOO, KOGIELEUM

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Area;Automobile Driving;Bacillus;Biological Markers;biomarker signature;Caring;case finding;Clinic;Communities;community burden;community transmission;Coupled;COVID-19 pandemic;Data;Data Element;data integration;design;Detection;Diagnostic;Disease;Early Diagnosis;Early identification;Early treatment;effective therapy;Epidemic;Evaluation;Exhibits;Failure;fighting;General Population;Genetic Transcription;genome sequencing;Genomics;Geography;Health system;Healthcare Systems;Heterogeneity;High Prevalence;HIV/TB;Household;improved;Incidence;Individual;Infection;innovation;Interruption;Intervention;Investigation;Link;Locales;Location;Maps;Methods;Modeling;molecular diagnostics;National Institute of Allergy and Infectious Disease;Natural History;novel;novel diagnostics;novel strategies;pathogen;Patients;Pattern;peri-urban;Population;Preventive therapy;programs;Public Health;Random Allocation;Research Priority;RNA;screening;South Africa;Southern Africa;Sputum;Statistical Data Interpretation;Statistical Models;Study models;success;Symptoms;Target Populations;Testing;Thoracic Radiography;tool;transmission process;Trees;Tuberculosis;Tuberculosis diagnosis;tuberculosis treatment;Visit;Vulnerable Populations;Whole Blood;whole genome;Work

PROJECT_TITLE: Targeting TB transmission hotspots to find undiagnosed TB in South Africa: a genomic, geospatial and modeling study (TARGET- TB)

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

PHR: Age-related dementia is a significant and growing burden on our society – the most well known of which is Alzheimer's disease (AD) – and chronic sleep disruption is a pervasive feature of contemporary life that is associated with and exacerbated in AD. This project will examine the idea that sleep quality is more important than sleep quantity, and will investigate the underlying biological mechanisms of this process, as well as explore novel strategies for improving sleep and treating deleterious inflammation in the brain.

PI_NAMEs: BACHSTETTER, ADAM D;DUNCAN, MARILYN J.;MURPHY, MICHAEL PAUL (contact);O'HARA, BRUCE FREDERICK;SUNDERAM, SRIDHAR

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: abeta accumulation;Abeta clearance;Acceleration;Address;Affect;age related;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Anti-Inflammatory Agents;Astrocytes;Attenuated;beta amyloid pathology;Biological;Brain;Chronic;circadian;circadian pacemaker;Cognition;Cognitive deficits;Correlative Study;Deceleration;Dementia;Demographic Factors;Deposition;design;Development;Disease;Disease Progression;Exhibits;Family;Frequencies;Human;Impaired cognition;Impairment;improved;improvement on sleep;Inflammation;Inflammatory;Knock-in Mouse;Life;Life Style;Light;Link;Mediating;Mediator;Medical History;Microglia;middle age;mild cognitive impairment;Modeling;Moods;mouse model;Mus;Nerve Degeneration;neuroinflammation;neuropathology;neurotoxic;Noise;noise exposure;novel;novel strategies;novel therapeutic intervention;Pathology;Personal Satisfaction;Pharmaceutical Preparations;pharmacologic;Phase;Phase I Clinical Trials;pre-clinical;prevent;Process;response;Rest;Risk;Role;Schedule;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep quality;sleep quantity;Slow-Wave Sleep;Societies;Synapses;System;Temperature;Testing;Time;Work

PROJECT_TITLE: Sleep Fragmentation and Alzheimer’s Disease

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - B;Immunization;Immunotherapy;Infectious Diseases;Liver Disease;Vaccine Related

ORG_CITY: ALBANY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ALBANY MEDICAL COLLEGE

PHR: PROJECT NARRATIVE Chronic hepatitis B virus (HBV) infection affects more than 250 million people worldwide and is a significant health problem because it substantially increases the risk for developing serious liver diseases such as cirrhosis and cancer. New therapeutic approaches for HBV that improve antiviral immunity hold substantial promise for controlling this infection. The goal of the proposed research is to understand the mechanisms of immunological dysfunction that must be successfully overcome to cure chronic HBV infection.

PI_NAMEs: ROBEK, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Acute Hepatitis;adaptive immune response;Affect;amino acid metabolism;Animal Model;Antibodies;antiviral immunity;Apoptotic;arginase;B-Lymphocytes;Blood;CD8-Positive T-Lymphocytes;Cell Physiology;Cell surface;Cells;Cessation of life;Chronic Hepatitis B;chronic infection;Cirrhosis;CTLA4 gene;cytokine;Dependovirus;Development;Environment;Enzymes;exhaustion;experimental study;Foundations;Frequencies;Functional disorder;Future;Gene Modified;Goals;Health;Hepatitis B Virus;Hepatocyte;Human;Immune;Immune response;Immune System Diseases;Immune Tolerance;Immunization;Immunologics;Immunotherapeutic agent;Immunotherapy;improved;Induction of Apoptosis;Infection Control;insight;Interleukin-10;intrahepatic;Killer Cells;Knowledge;Ligands;Liver;Liver diseases;Malignant Neoplasms;Measures;Mediating;Mediator;Metabolic;Metabolic Pathway;Modeling;mouse model;Mus;Natural Killer Cells;novel therapeutic intervention;Pathway interactions;Patients;Peripheral;Persons;Phenotype;Physiological;Production;programmed cell death protein 1;Proteins;Publishing;receptor;receptor function;Receptor Signaling;Regulation;Regulatory Pathway;Regulatory T-Lymphocyte;Reproducibility;Research;Risk;Role;Signal Pathway;Signal Transduction;T cell response;T-bet protein;T-Lymphocyte;Testing;therapeutic immunization;therapeutic vaccine;Tissues;TNFSF10 gene;transcription factor;Transforming Growth Factor beta;Tryptophan 2,3 Dioxygenase;vaccine efficacy;vector-based vaccine;Viral;Viral Antigens;Viral Genome;Virus;Virus Diseases;virus host interaction;Virus Replication

PROJECT_TITLE: Human mechanisms of virus persistence in an AAV-based mouse model of chronic HBV infection

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE This proposal seeks to enhance the potency of adoptive T cell immunotherapies and chimeric antigen receptor T cells (CART) against cancer by removing a key inhibitory factor, CD5, from T-cells. The proposed research is highly relevant to public health because CART immunotherapy, despite being now routine clinical practice, still fails in a significant subset of patients. The project is relevant to those parts of the NCI’s mission that pertain to the treatment of cancer, and the advancement of scientific knowledge and help all people live longer, healthier lives.

PI_NAMEs: RUELLA, MARCO  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Affinity;Antigens;antitumor effect;B lymphoid malignancy;B-Cell Leukemia;B-Lymphocytes;Behavior;Calcium Signaling;cancer immunotherapy;cancer therapy;CBL gene;CD19 gene;CD8-Positive T-Lymphocytes;Cell Death Induction;Cell Physiology;Cells;chimeric antigen receptor T cells;Chronic;Clinical;clinical practice;Clinical Trials;clinically relevant;Complex;CRISPR/Cas technology;CTAG1 gene;cytokine;cytotoxicity;Data;Development;digital;Disease remission;Disinhibition;effector T cell;engineered T cells;ERBB2 gene;exhaustion;experience;Exposure to;first-in-human;Flow Cytometry;Goals;Grant;growth factor receptor-bound protein 2;Hematology;Human;human model;Immune checkpoint inhibitor;Immunocompetent;immunological synapse;immunoregulation;Immunotherapy;improved;In Vitro;in vivo;innovation;Investigation;Knock-out;Knowledge;leukemia/lymphoma;Lymphoma;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Mediator;Melanoma;mesothelin;Mission;Modeling;mouse model;Multiple Myeloma;Mus;next generation;novel;Outcome;Pathway interactions;patient subsets;Patients;PD-1/PD-L1;performance tests;Peripheral;Persons;Phosphorylation;Pre-Clinical Model;Process;Production;programmed cell death protein 1;Proliferating;PTPN6 gene;Public Health;Receptor Signaling;Refractory;refractory cancer;Relapse;release of sequestered calcium ion into cytoplasm;Reporting;Research;response;Role;Safety;safety testing;scavenger receptor;Scientific Advances and Accomplishments;side effect;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Solid;Solid Neoplasm;T cell therapy;T-Cell Activation;T-Cell Leukemia;T-Cell Lymphoma;T-Cell Receptor;T-Lymphocyte;Technology;Testing;transcription factor;tumor;tumor microenvironment;tumor-immune system interactions;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: MODULATION OF CD5 SIGNALING TO ENHANCE ADOPTIVE T-CELL THERAPIES FOR CANCER

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: RENO

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Overall Network Organization and Management Plan – Narrative The IDeA Network for Biomedical Research Excellence (INBRE) program enhances Nevada’s biomedical research, training, and infrastructure, which strengthens healthcare and biomedical workforce and leadership in the state and makes Nevada researchers more competitive for federal research funding.

PI_NAMEs: BAKER, JONATHAN E. (contact)

PROGRAM_OFFICER_NAME: NANDA, JAGPREET SINGH

PROJECT_TERMS: Award;base;Bioinformatics;Biomedical Research;career;Cell Differentiation process;cell growth;Centers of Research Excellence;Cloud Computing;Collaborations;college;Communication;Communities;computerized data processing;COVID-19;Data Science Core;Data Storage and Retrieval;design;Development;Doctor of Philosophy;Education;Educational process of instructing;Educational workshop;Ensure;Equipment;experience;Faculty;Funding;Genomics;Goals;Grant;Growth;Health;Healthcare;Human;improved;Infrastructure;Institution;Interdisciplinary Study;interest;Lead;Leadership;medical schools;meetings;Mentorship;Minority;Mission;Nevada;outreach;outreach program;Privatization;Program Research Project Grants;programs;Proteomics;Research;research faculty;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Research Support;Resources;response;Scientist;Services;Site Visit;Structure;Students;success;Time;Training;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;web site;Work;Workforce Development;Writing

PROJECT_TITLE: Nevada IDeA Networks of Biomedical Research Excellence (INBRE)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research

PROJECT_TERMS: Address;Advisory Committees;Annual Reports;Award;Biomedical Research;brain health;Cell Differentiation process;cell growth;Centers of Research Excellence;Characteristics;Clinical;Collaborations;Communication;Data;Data Science Core;Databases;Development;Educational process of instructing;Ensure;Evaluation;Faculty;flexibility;Funding;Goals;improved;Institution;Leadership;Link;meetings;member;Mentors;Mission;Network Infrastructure;Nevada;outreach;outreach program;Program Research Project Grants;programs;Progress Reports;Research;Research Activity;research faculty;Resource Sharing;Resources;Services;Sister;Students;success;Training;undergraduate research experience;undergraduate student;United States National Institutes of Health;web site;Work

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Genetics

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative We focus on highly characterized bacterial RNA polymerases, which have a high degree of conservation of structure and function from bacteria to man. The bacterial RNA polymerase is a proven target for antimicrobials, such as rifampicin (or its derivatives), widely used in combination therapy to treat tuberculosis, but bacterial strains resistant to rifampicin arise with appreciable frequency, compromising treatment. Insights into the mechanism of bacterial transcription, as well as into the inhibition mechanism of inhibitors, can lead to new avenues for the development of antimicrobials.

PI_NAMEs: DARST, SETH A. (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Antibiotics;antimicrobial;Bacteria;Bacterial RNA;Behavior;Binding;Biology;Chemicals;Combined Modality Therapy;Complex;Cryoelectron Microscopy;Development;Dissociation;DNA;DNA-Directed DNA Polymerase;DNA-Directed RNA Polymerase;Elements;Enzymes;Frequencies;Gene Expression;Genetic Transcription;Goals;Holoenzymes;inhibitor;insight;interest;man;melting;Methods;Molecular Conformation;Molecular Machines;Prokaryotic Cells;promoter;Regulation;resistant strain;Rifampicin resistance;Rifampin;RNA;Series;small molecule;structural biology;Structure;three dimensional structure;Transcript;transcription termination;tuberculosis treatment;Visualization

PROJECT_TITLE: Structure, function, and regulation of the bacterial transcription cycle

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative There is currently a shortage of medical student trainees who are entering into careers in academic medicine as physician-scientists; furthermore, diversity in the pool of physician-scientist pathway trainees fails to reflect the diversity of our communities. This training program entitled “Medical Student Summer Research Program in Infection and Immunity” aims to augment medical research-training opportunities and mentorship for a diverse pool of medical students at the University of Minnesota Medical School by taking advantage of the strength of our immunological sciences. With success in this effort, an increased and more diverse proportion of our medical student population will enter into physician-scientist training pathway residency programs.

PI_NAMEs: MUELLER, DANIEL L (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Advisory Committees;aspirate;Autoimmune Diseases;career;Career Choice;direct patient care;Employment;Enrollment;experience;Faculty;Financial Support;Funding;Grant;Health;Human;immune system function;Immunity;Immunology;Individual;Infection;Instruction;interest;Investigation;Laboratories;Lead;Leadership;Longitudinal Surveys;Medical;Medical Research;medical schools;Medical Students;Medicine;member;Mentors;Mentorship;Mind;Minnesota;Monitor;Oral;Pathogenesis;Pathway interactions;Perception;Performance;Physicians;posters;pre-doctoral;programs;Progress Reports;Publishing;Records;recruit;Research;Research Personnel;Research Training;Residencies;Rheumatology;Scientist;Students;success;summer research;summer student;Surveys;Talents;Teacher Professional Development;Training;undergraduate student;Universities;Work;Writing

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: PETEREIT, JULIA  (contact)

PROJECT_TERMS: academic minor;Administrative Supplement;animal imaging;Applications Grants;Award;Big Data;Bioinformatics;biomedical data science;Biomedical Research;Biometry;Biostatistical Methods;Cell Differentiation process;cell growth;Centers of Research Excellence;Cloud Computing;Cloud Service;Collaborations;college;Communication;Complex;Consultations;Core Facility;cost;Data;Data Science;Data Science Core;Data Set;data sharing;Data Storage and Retrieval;design;Educational process of instructing;Educational workshop;Ensure;Event;experience;Experimental Designs;Faculty;Funding;Generations;Genomics;Goals;graduate student;improved;innovation;Institution;Institutionalization;Investments;Lead;Machine Learning;Manuscripts;meetings;Mentored Clinical Scientist Development Program;Mentors;Methods;multimodal data;multiple omics;neuroimaging;Nevada;next generation;outreach;outreach program;Paper;Performance;Preparation;preservation;programs;Proteomics;Recommendation;Research;research and development;Research Design;research faculty;Research Infrastructure;Research Personnel;Research Training;Resources;Savings;Science, Technology, Engineering and Mathematics Education;service providers;Services;single cell sequencing;Specific qualifier value;Students;Supercomputing;Technology;Testing;Training;Training Programs;transcriptomics;undergraduate research;undergraduate student;Universities;web services;Work

PROJECT_TITLE: Data Science Core for Biomedical Research


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Precision Medicine;Primary Health Care;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative We aim to optimize treatment for depression by determining which patients will do better on antidepressant medication versus behavioral activation psychotherapy, the two recommended treatments for depression in primary care, through a machine learning generated precision treatment rule utilizing baseline patient characteristics.

PI_NAMEs: HOLLON, STEVEN DENNIS;PATEL, VIKRAM H (contact)

PROGRAM_OFFICER_NAME: CAMPBELL-ROSEN, HOLLY RENEE

PROJECT_TERMS: Academia;Adherence;Advocate;anti-depressive agents;Behavioral;burden of illness;Caring;Characteristics;Clinical;Collaborations;Cost Analysis;cost effective;cost effectiveness;Cost Effectiveness Analysis;Detection;Disease remission;Effectiveness;effectiveness evaluation;effectiveness outcome;ethnic diversity;European ancestry;Exclusion Criteria;Fluoxetine;functional outcomes;genetic predictors;genome wide association study;Genotype;Goals;health care delivery;Health system;improved outcome;India;Individual;individual patient;individual variation;insight;Intervention;Knowledge;Machine Learning;Masks;Measures;Mediation;Mediator;Mental Depression;Mental Health;Mental Health Services;National Institute of Mental Health;Nepal;Neurocognitive;optimal treatments;Outcome;Participant;Patient-Focused Outcomes;Patients;personalized medicine;Pharmaceutical Preparations;Policies;polygenic risk score;precision medicine;Precision therapeutics;Prediction of Response to Therapy;Primary Care;primary care patient;primary care setting;Probability;programs;psychogenetics;psychologic;Psychotherapy;Quality-Adjusted Life Years;Random Allocation;Randomized;Recommendation;Recovery;relative cost;relative effectiveness;Research;Research Infrastructure;Resource-limited setting;response;routine care;Sample Size;Sampling;Selective Serotonin Reuptake Inhibitor;socioeconomics;Specialist;Specificity;Testing;treatment optimization;Treatment outcome;treatment trial;Work;World Health Organization

PROJECT_TITLE: Improving Outcomes in Depression in Primary Care in a Low Resource Setting


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Mental Health;Neurodegenerative;Neurosciences;Prevention;Primary Health Care;Sleep Research

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: This application is responsive to the 2015 AD Summit recommendation to “elucidate the short- and long-term consequences of disrupted and optimized sleep on brain aging and AD.” Sleep and circadian rhythm disturbances are common in elderly persons with mild cognitive impairment (MCI) and dementia, including Alzheimer’s disease and related dementias (ADRD). This proposed K23 award will support a research career to examine cross-sectionally and longitudinally the association of poor sleep and disrupted circadian rhythms with cognitive diagnoses, including normal cognition, cognitive impairment without MCI, amnestic MCI single domain, amnestic MCI multiple domain, and ADRD.

PI_NAMEs: KERNER, NANCY A (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: actigraphy;Adult;Age;aging brain;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease related dementia;amnestic mild cognitive impairment;Ancillary Study;Anxiety;Award;behavioral neurology;career;career development;Categories;Chronic;circadian;Circadian Dysregulation;Circadian Rhythm Sleep Disorders;Circadian Rhythms;Clinical;clinical diagnosis;Cognition;Cognitive;cognitive testing;Cross-Sectional Studies;Data;Data Set;Dementia;dementia risk;Detection;Development Plans;Diabetes Mellitus;Diagnosis;Diagnostic;Disease;Drowsiness;Early Diagnosis;Early treatment;Elderly;Evaluation;Genotype;Goals;Guidelines;Health Personnel;Hour;human old age (65+);Impaired cognition;Impairment;Individual;K-Series Research Career Programs;Link;Measures;Mediation;Medical;Medicine;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;mild cognitive impairment;National Institute on Aging;National Institute on Alcohol Abuse and Alcoholism;neuropathology;neuropsychiatry;New York City;Obstructive Sleep Apnea;older adult;Participant;patient oriented research;Persons;poor sleep;Populations at Risk;Primary Care;primary care practice;primary care provider;primary care services;Principal Investigator;professor;programs;Prospective Studies;psychiatric comorbidity;Psychiatry;Questionnaires;Recommendation;recruit;referral services;Research;research and development;Research Personnel;Research Project Grants;Research Training;Rest;Risk Factors;sex;Sleep;sleep abnormalities;Sleep Disorders;Sleep disturbances;sleep onset;Sleeplessness;Smell Perception;sound;Statistical Data Interpretation;symposium;Tauopathies;Testing;Time;Training;Training Activity;Universities;β-amyloid burden

PROJECT_TITLE: Assessment of Sleep and Circadian Rhythms in Elderly Persons with Cognitive Concerns Evaluated for Alzheimer's Disease and Related Dementias (ADRD)

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: NARRATIVE We propose the development of Lipo-JICG – a molecularly targeted, dye-containing, liposomal photoacoustic contrast agent – for the detection and therapy-monitoring of disease in vivo. Coupled with new signal/image processing algorithms and robust quality-control protocols, we can enable reproducible, quantitative, longitudinal, and tomographic imaging of disease and therapeutic response, providing a powerful discovery tool in medical research that has potential for future clinical translation.

PI_NAMEs: BOUCHARD, RICHARD R. (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: 3-Dimensional;absorption;Acceleration;Address;Algorithms;Anatomy;Animal Disease Models;Animal Model;Animals;Antibodies;Binding;Biochemical;Biodistribution;bioluminescence imaging;biomarker evaluation;Blood;Cancer Center;cancer therapy;Cell Culture Techniques;cellular imaging;Cholesterol;Clinical;clinical translation;Commercial grade;Communities;Complement;contrast imaging;Contrast Media;Coupled;Data;Detection;detection limit;Development;Diagnostic Imaging;Disease;Doctor of Medicine;Drug Delivery Systems;drug discovery;Drug Kinetics;Drug Targeting;Dyes;Encapsulated;Epidermal Growth Factor Receptor;Evaluation;Foundations;Functional Imaging;fundamental research;Future;Generations;Goals;Hemoglobin;Image;image processing;imaging approach;imaging capabilities;Imaging Device;imaging modality;imaging platform;imaging system;Imaging Techniques;Imaging technology;improved;in vivo;Indocyanine Green;industry partner;interest;Label;large scale production;Letters;Lighting;Liposomes;Malignant neoplasm of ovary;Mediating;Medical;Medical Research;millimeter;Modeling;Molecular;molecular imaging;molecular marker;Molecular Target;Monitor;monomer;Morphology;mouse model;nanoGold;nanorod;Neoplasms;neoplastic cell;novel;optical imaging;Optics;Outcome;Oxygen;Pathologic Processes;Pathology;Penetration;personalized medicine;pharmacologic;Phospholipids;photoacoustic imaging;Physiologic pulse;Physiological;Positioning Attribute;pre-clinical research;preclinical imaging;preclinical study;prevent;Process;Production;Property;Protocols documentation;Quality Control;quantitative imaging;Reproducibility;Research Personnel;Research Proposals;Resolution;Safety;scale up;Sensitivity and Specificity;Signal Transduction;Silicon Dioxide;Specificity;System;Technology;Therapeutic;Tissues;tomography;tool;Toxic effect;Translational Research;Translations;treatment response;Validation;Visualization

PROJECT_TITLE: Molecular Photoacoustic Imaging for Diagnostics and Therapy Monitoring


PI_NAMEs: ROBLETO, EDUARDO A (contact)

PROJECT_TERMS: Advisory Committees;Agreement;Award;base;Biomedical Research;career;career development;Cell Differentiation process;cell growth;Collaborations;college;Communication;community college;Data;design;Development;Educational process of instructing;Eligibility Determination;experience;Extramural Activities;Faculty;Faculty Recruitment;faculty support;Feedback;Funding;Goals;Grant;Growth;Health;Healthcare;improved;Institution;interest;Laboratories;Lead;member;Mentors;Mentorship;Nevada;Outcome;outreach;Paper;Privatization;Process;Program Research Project Grants;programs;Publications;Publishing;recruit;Research;research and development;research faculty;Research Institute;Research Personnel;Research Project Grants;Resources;Services;southern nevada;Students;success;Teacher Professional Development;Time;Training;undergraduate research experience;undergraduate student;Universities;Walking;Writing

PROJECT_TITLE: Developmental Research Project Program


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PI_NAMEs: VANCE, RUSSELL E (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Address;Bacillus anthracis;C-terminal;Cells;Detection;Dissection;Funding;Health;Human;Immune;Immune response;Inflammasome;innate immune sensing;Innate Immune System;Instruction;lethal factor;Molecular;multicatalytic endopeptidase complex;novel;pathogen;pathogenic bacteria;pathogenic microbe;Peptide Hydrolases;Process;sensor;Shigella flexneri;Signal Transduction;Toxin;ubiquitin-protein ligase;Virulence;Virulence Factors;Work

PROJECT_TITLE: Functional and Structural Dissection of Inflammasome Activation

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Untreated cases of early childhood caries (ECC) may expose a child to pain, potentially life- threating infection, failure to thrive, learning difficulties, among several other problems. Building upon the rigor of our prior research, we propose a Stage II research according to the NIH Stage Model that will compare the efficacy of videotaped autonomy-supportive oral health messages framed by the self-determination theory (SDT) to more traditional neutral videotaped messages among mother-child dyads enrolled in Special Supplemental Food Program for Women, Infants and Children (WIC) programs located in a rural population with large Hispanic and African American minorities. It is hoped that, in the future, our autonomy-supportive messages can (1) be used in numerous settings (i.e. public health clinics, hospitals, medical/dental offices); (2) be disseminated through the social media (i.e. Facebook) and website (i.e. YouTube); (3) increase access to early dental prevention at low-cost targeted especially for high-caries risk minority groups; (4) break the walls of language barrier by narrating the messages in all desirable languages; and (5) be used later on by other researchers and clinicians as an additional tool to their strategies to prevent ECC.

PI_NAMEs: WEBER-GASPARONI, KARIN  (contact)

PROGRAM_OFFICER_NAME: MATTIA, JILL

PROJECT_TERMS: Address;African American;Age;Age Months;Behavior;behavior change;Behavior Therapy;Behavioral;Birth;burden of illness;Caries prevention;Child;Child Rearing;Clinic;Clinical Trials;Clinical Trials Design;comparative efficacy;Competence;Control Groups;cost;Data;Dental;Dental caries;Dental Facilities;Dental Hygiene;Dental Offices;Dental Plaque;Diet Habits;Disease;Disparity;early childhood;Education;Effectiveness;effectiveness evaluation;Enrollment;evidence base;experience;experimental group;Exposure to;Facebook;Failure to Thrive;falls;Food Supplements;Funding;Future;Goals;Grant;Habits;Health behavior;health care service;Health education;Health Promotion;Healthcare;high risk;Hispanic Americans;Hospitals;improved;Incidence;Infant;Infection;Institutional Review Boards;instrument;Intention;interest;Intervention;Iowa;Knowledge;Language;Lead;Leadership;Learning Difficulty;Life;Literature;Longitudinal Studies;lower income families;Manuals;Medical;Methods;Minority;minority children;Minority Groups;Modeling;Monitor;Mothers;Motivation;Narration;nutrition;operation;Oral health;Outcome;Pain;Parents;Patient Self-Report;Phase;pilot test;Pregnancy;Pregnant Women;prevent;Prevention;Preventive;preventive intervention;primary outcome;Procedures;Process;programs;psychoeducational intervention;psychologic;Psychological Theory;Public Health;Randomized;randomized, clinical trials;Recommendation;recruit;Research;Research Personnel;Research Project Grants;Risk;Rural Minority;Rural Population;Salivary;secondary outcome;Self Determination;Series;Site;social media;Streptococcus mutans;Structure;theories;tool;United States National Institutes of Health;Videotape;Vulnerable Populations;web site;Woman;Work

PROJECT_TITLE: Birth to Three – Cavity Free: Effectiveness of a Psychoeducational Intervention for ECC Prevention


NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Human Genome;Lupus;Patient Safety;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE – RELEVANCE Testing for antinuclear antibodies (ANA) is a common practice to screen for systemic lupus erythematosus, since the test is almost always positive in lupus even years before the disease onset. However, a large proportion of people without autoimmune disease also have a positive ANA test, and it is not known whether a positive test increases the risk for other adverse outcomes. This project aims (a) to discriminate who is at high risk for lupus from among individuals with a positive ANA test and (b) to define the risk for positive ANA individuals without an autoimmune disease in order to provide better health care advice and improve the care of lupus patients.

PI_NAMEs: KAWAI, VIVIAN K (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Academic Medical Centers;accurate diagnosis;Address;adverse outcome;Affect;Animals;Antibodies;Antibody-mediated protection;Antinuclear Antibodies;Arthralgia;Autoantigens;Autoimmune Diseases;biobank;Bioinformatics;cancer risk;Cardiovascular system;Caring;Catalogs;Clinical;Clinical Data;clinical phenotype;clinical predictive model;clinical risk;clinically significant;Computerized Medical Record;Data;Detection;Diagnosis;Diagnostic;diagnostic strategy;Disease;disorder risk;Early Diagnosis;Early treatment;Electronic Health Record;Future;General Population;Genetic;genetic approach;genetic architecture;Genetic Determinism;genetic information;Genetic Risk;Genetic Techniques;Genome;genome wide association study;Genotype;Healthcare;high risk;Human;Immune;improved;Individual;Infection;Inflammation;Knowledge;Link;Lupus;Mendelian disorder;Modeling;Morbidity - disease rate;mortality;Musculoskeletal;Myalgia;novel;Onset of illness;Pathogenicity;Patients;Persons;phenome;Phenotype;predictive modeling;predictive tools;Prevalence;prevent;Reaction;renal damage;Reporting;Research Personnel;Risk;risk prediction;side effect;Symptoms;Systemic Lupus Erythematosus;Techniques;Testing;Time;Uncertainty;Validation;virtual

PROJECT_TITLE: Genome and Phenome to Define Disease Risk with Antinuclear Antibodies

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative Many human diseases arise from defects in phosphoinositide signaling, ubiquitination, and dysregulation of mitosis. This proposal investigates a fundamental cellular mechanism linking these important pathways.

PI_NAMEs: BASKIN, JEREMY  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Affect;Anaphase;anaphase-promoting complex;Behavior;Binding;Binding Proteins;biochemical tools;Biological Assay;Biotinylation;Cell Cycle;Cell Cycle Checkpoint;Cell Cycle Progression;Cell Cycle Stage;Cell membrane;Cells;Cellular Membrane;Code;Complex;Cytoskeleton;Data;Defect;Dimensions;Disease;Event;Exhibits;G2/M Transition;Goals;Health;human disease;Immunofluorescence Immunologic;In Vitro;in vitro activity;in vivo;Interphase;Link;Lipids;Location;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Membrane;Membrane Lipids;Metaphase;Methods;Microtubules;Mitosis;Mitotic;Molecular;multicatalytic endopeptidase complex;novel;Pathway interactions;PH Domain;Phenotype;Phosphatidylinositols;Phosphorylation;Play;Process;programs;Property;protein degradation;Proteins;Proteolysis;Proteomics;recruit;Regulation;Research;RNA Interference;Role;Signal Transduction;Signaling Protein;Small Interfering RNA;Spatial Behavior;spatiotemporal;Structure;System;Testing;tool;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Spatiotemporal control of ubiquitination by phosphoinositide-binding proteins

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Cancer;Immunotherapy;Nanotechnology;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: WALTHAM

ORG_DEPT: CHEMISTRY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Narrative  The overall goal of this research is to develop innovative approaches for overcoming drug resistance in cancer therapy. Developing nanomedicines by subcellular enzyme-instructed self-assembly (sEISA) to selectively kill cancer cells and to overcome the drug resistance, this approach will ultimately lead to a new cancer therapy for millions of people who will need anticancer treatment in the future, and thus improving health of the Nation.

PI_NAMEs: XU, BING  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Address;Alkaline Phosphatase;anti-cancer;anti-cancer treatment;anticancer activity;Antineoplastic Agents;Biochemical Reaction;cancer cell;Cancer cell line;cancer complication;Cancer Patient;Cancer Survivorship;cancer therapy;Cell Physiology;Cell surface;Cells;Cellular Assay;cellular targeting;Cytoplasm;design;Diameter;Drug resistance;Engineering;Enzymes;Funding;Future;Genes;Genomic Instability;Goals;Growth;Health;Hospitals;Immunosuppression;Immunotherapy;improved;in vivo;innovation;Interruption;invention;Ligands;Malignant neoplasm of ovary;Malignant Neoplasms;medical schools;Metastatic Osteosarcoma;Methods;Mitochondria;Molecular;molecular assembly/self assembly;Molecular Mechanisms of Action;mouse model;multidrug resistance inhibition therapy;nanofiber;nanomedicine;Nanostructures;Osteosarcoma;Peptides;Persons;Pharmaceutical Preparations;Process;Proteins;Public Health;receptor;receptor binding;Research;Resistance;self assembly;Serous;small molecule;spatiotemporal;Testing;tumor;tumor heterogeneity;tumor microenvironment;Woman;Work;Xenograft procedure

PROJECT_TITLE: Subcellular enzyme-instructed self-assembly for molecular anticancer nanomedicines

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: INDIANAPOLIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Leverage the Indiana Clinical and Translational Sciences Institute to foster the development of a diverse clinical and translational workforce within Indiana through education and immersive experiences of students from historically marginalized backgrounds enrolled in Ivy Tech, our statewide community college system.

PI_NAMEs: ALLEN, MATTHEW R (contact)

PROGRAM_OFFICER_NAME: KRASNOVA, IRINA N

PROJECT_TERMS: Accreditation;Advisory Committees;African American;Awareness;Black race;career;career awareness;Career Choice;Career Exploration;Clinical;Clinical Research;Clinical Sciences;cohort;college;community college;Country;Development;didactic education;disadvantaged background;economic disparity;Education;education pathway;education research;effectiveness evaluation;Enrollment;Environment;Evaluation;experience;Exposure to;Fostering;Goals;high school;high school program;Hispanic;Immersion;implementation science;Indiana;Infrastructure;Latinx;Leadership;Learning Module;marginalized population;Medicine;Mentors;Mentorship;Pathway interactions;Population Sciences;Program Development;programs;public education;racial diversity;Reproducibility;Research;Research Ethics;Science;STEM field;STEM program;Structure;student participation;Students;System;translational pipeline;Translational Research;undergraduate education;undergraduate student;Universities;virtual;Work;Workforce Development

PROJECT_TITLE: Clinical and Translational Science Workforce Development through a Statewide Community College Partnership