ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Bioengineering;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Immunotherapy;Nanotechnology;Orphan Drug;Rare Diseases;Women's Health Research

ORG_CITY: Los Angeles

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Sjögren's syndrome is an an autoimmune disease associated with local inflammation and decreased function of lacrimal and salivary glands, as well as systemic inflammation of many other internal organs. Treatment options are limited, possibly because approved treatments do not achieve immunomodulation at both local glandular and systemic sites, both of which sustain disease. Capitalizing on the novel properties of elastin-like polypeptides, we develop distinct strategies to more effectively treat local, glandular and systemic symptoms with immunomodulatory agents, and then explore their efficacy and toxicity in combination, all in murine models of the disease.

PI_NAMEs: HAMM-ALVAREZ, SARAH F (contact);MACKAY, JOHN ANDREW

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Affect;Affinity;American;Antibodies;Artificial Tears;Autoantibodies;Autoimmune;Autoimmune Diseases;B-Cell Lymphomas;belimumab;Binding;Biodegradation;Biodistribution;Biological Availability;Biological Products;Cell Adhesion Molecules;Cells;Chimeric Proteins;Clinical;clinically relevant;Combined Modality Therapy;Complex;Cornea;Cyclosporine;cytokine;design;Development;diabetic;Disease;disease model;Dose;Drug Carriers;Drug Kinetics;Dry Eye Syndromes;effective therapy;efficacy evaluation;Elastin;elastin-binding protein;Engineering;Epithelial Cells;Epithelium;Exhibits;extracellular;Extracellular Domain;Eye;eye dryness;Fatigue;Female;Flow Cytometry;Fluorescein;Formulation;Histologic;Histology;Hydroxychloroquine;IL17 gene;immune modulating agents;Immune system;immunoregulation;Immunosuppression;Immunosuppressive Agents;improved;in vitro activity;Inbred NOD Mice;Individual;Infiltration;Inflammation;Injections;innovation;Intuition;Lacrimal gland structure;Link;Liquid substance;Local Therapy;Localized Disease;loss of function;male;Measurement;Measures;Methotrexate;Modeling;Molecular Target;mouse model;nanomedicine;nanoparticle;nanopolymer;Non obese;NOR Mouse;novel;novel strategies;novel therapeutics;ocular surface;Oral;Organ;Pathogenesis;Patients;Peptides;Pharmaceutical Preparations;Polymers;polypeptide;Production;Property;Proteins;receptor;Regimen;Risk;rituximab;Saliva;Salivary;Salivary Glands;Serum;sex as a biological variable;Sialadenitis;Sirolimus;Site;Sjogren's Syndrome;Stains;subcutaneous;Submandibular gland;success;symptom management;Symptoms;Systemic disease;systemic inflammatory response;Systemic Therapy;Tacrolimus Binding Protein 1A;Tacrolimus Binding Proteins;Technology;Testing;Therapeutic;Time;Tissue imaging;tocilizumab;Topical application;Toxic effect;Transition Temperature;Treatment Efficacy;Treatment Protocols;Visceral;Xerostomia

PROJECT_TITLE: Protein-polymer nanomedicine for Sjogren's Syndrome

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Cardiovascular;Data Science;Diabetes;Heart Disease;Nutrition;Obesity;Organ Transplantation;Pediatric;Prevention;Transplantation

ORG_CITY: GAINESVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE This two-phased U24 proposal seeks to: 1) establish a Cardiovascular Repository-Type 1 Diabetes (CARE-T1D) program through the collection and biobanking of transplant-quality specimens from human organs donors as well as performance of quality control studies and basic histopathologic examination, and 2) serve as a Coordinating Center for evaluating tissue requests, sample distribution, and data sharing. Specifically over the first two years (phase 1), we propose to collect a complete tissue panel— heart, kidney, vasculature, and blood— from a racially diverse pool of T1D, type 2 diabetes (T2D) and age/sex-matched no-diabetes donors with cardiovascular disease (CVD), providing investigators with the necessary tissue resources to conduct extensive research on the cellular and molecular mechanisms underlying CVD development in individuals with T1D versus those with T2D or without diabetes. For phase 2 (years 3-5), we will distribute tissue samples across a network of qualified investigators, host annual meetings to promote collaborative research, coordinate data uploads to public repositories in compliance with NIH data sharing policies, and create a public facing database that allows for access, integrated viewing and analysis of comprehensive data generated using a broad range of technologies.

PI_NAMEs: ATKINSON, MARK A. (contact)

PROGRAM_OFFICER_NAME: JONES, TERESA L Z

PROJECT_TERMS: Address;Age;Anatomy;Animal Model;Aorta;Atlases;Attention;autonomic neuropathy;Award;Big Data;biobank;biomarker discovery;Blood;Blood Glucose;Blood Vessels;Board Certification;Cadaver;Calcium;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cause of Death;Cells;central database;Cerebrovascular Disorders;cohort;Collaborations;Collection;Complication;Coronary artery;Coronary heart disease;Data;data acquisition;data portal;Data Set;data sharing;Databases;Deposition;Development;diabetes control;Diabetes Mellitus;diabetes risk;diabetic;diabetic cardiomyopathy;Diabetic Nephropathy;Diagnosis;digital pathology;Disease;Disease Progression;Dissection;Drug or chemical Tissue Distribution;Early Diagnosis;Evaluation;experience;FAIR principles;Freezing;glycemic control;Glycosylated hemoglobin A;Goals;Heart;High Prevalence;histopathological examination;Human;Human BioMolecular Atlas Program;human tissue;Hypertension;Image;Immune;Individual;Infrastructure;Institution;Insulin-Dependent Diabetes Mellitus;International;Intervention;Kidney;Knowledge;Lead;Leadership;Life;Life Expectancy;life span;Link;Medical Records;meetings;Metadata;Modeling;Molecular;Mononuclear;Morbidity - disease rate;mortality;multimodal data;multimodality;Myocardium;Natural History;Neonatal;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Obesity;Organ;Organ Donor;Organ Procurements;Overweight;Pancreas;Pathogenesis;Pathogenicity;Pathologist;Pathology;Patients;Performance;Peripheral;Peripheral arterial disease;Persons;Phase;Phenotype;Plasma;Policies;Prediabetes syndrome;prevent;Prevention;Procedures;Process;Productivity;programs;Protocols documentation;public repository;Qualifying;Quality Control;racial diversity;Radiology Specialty;Recommendation;repository;Research;Research Personnel;Research Project Grants;Research Proposals;Risk Factors;Risk Reduction;Sampling;Scanning;Secure;Serum;Severity of illness;sex;Specific qualifier value;Specimen;Stains;Standardization;Technology;tissue resource;Tissue Sample;Tissues;Transplantation;treatment strategy;type I and type II diabetes;United States;United States National Institutes of Health;Visualization

PROJECT_TITLE: Biorepository and Coordinating Center for Studies on Cardiovascular Complications of Human Type 1 Diabetes


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Nutrition;Prevention

ORG_CITY: SEATTLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Diverticulitis is a common gastrointestinal indication for hospital admission, outpatient visits, and colon surgery in the U.S. We propose a randomized trial of a USDA Healthy Mediterranean-style Food Pattern versus standardized guidance on fiber intake for patients with diverticulitis to determine feasibility of a larger-scale effectiveness trial focused on the clinical outcome of recurrent diverticulitis; furthermore, we will examine plasma and fecal inflammatory biomarkers. Identifying a candidate intervention for secondary prevention and a biomarker of risk would have profound impacts on management and improve the lives of millions of patients with diverticulitis.

PI_NAMEs: FLUM, DAVID R (contact);STRATE, LISA L

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Address;Adherence;Ambulatory Care Facilities;American;Behavior Therapy;Behavioral;Biological Markers;Body mass index;Budgets;cardiovascular disorder prevention;Characteristics;Chronic;circulating biomarkers;Clinical;Clinical Trials;Colectomy;colon surgery;cost;Cross-Sectional Studies;density;Development;Diagnostic;Diet;dietary;Dietary Component;Dietary Fiber;dietary guidelines;Dietary Intervention;Dietary Practices;Disease;Diverticulitis;Drug usage;effectiveness evaluation;effectiveness trial;Electronics;Emergency department visit;evidence base;Exercise;feasibility trial;Feces;Feedback;Fiber;Food;Food Patterns;food restriction;Future;gastrointestinal;Guidelines;gut microbiome;gut microbiota;Health behavior;Health Food;high risk population;Hospitalization;Hour;improved;Incidence;Individual;Inflammation;Inflammatory;inflammatory marker;Inpatients;Intake;Interleukin-1 beta;Interleukin-10;Interleukin-6;Intervention;Intervention Trial;Investigation;Joints;Knowledge;Leukocyte L1 Antigen Complex;Life Style;Link;Malignant Neoplasms;Meat;Medical;Mediterranean Diet;men;Mission;modifiable lifestyle factors;modifiable risk;Morbidity - disease rate;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;Non-Steroidal Anti-Inflammatory Agents;novel;Nutrient;nutritional epidemiology;Obesity;Observational Study;Outcome;Outpatients;Pain;Participant;Pathogenesis;Pathway interactions;Patients;Pattern;pharmacologic;physical inactivity;pilot trial;Plasma;preference;Prevalence;prevent;Prevention;preventive intervention;Preventive measure;Primary Prevention;prospective;Prospective, cohort study;Provider;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Recording of previous events;Recurrence;recurrence prevention;response;response biomarker;Risk;Risk Factors;Sampling;Secondary Prevention;Serum;Smoke;Smoking;Standardization;systemic inflammatory response;treatment response;United States Department of Agriculture;Visit;willingness;Work

PROJECT_TITLE: Investigation of Medical Management to Prevent Episodes of Diverticulitis (IMPEDE) Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-B(02)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: PROVIDENCE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Guidance of axons to their targets is an important step in neural circuit assembly during embryonic development. The proposed study will elucidate the functions of a newly identified axon guidance cue, WFIKKN2, and its receptors in neuronal wiring. By providing insights into the basic mechanisms of axon pathfinding, this work can improve our understanding of disorders resulting from nervous system miswiring, and it has the potential to inform therapeutic approaches for neural circuit repair after physical injury or onset of neurodegenerative disease.

PI_NAMEs: JAWORSKI, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Afferent Neurons;Animals;Architecture;Area;Axon;axon growth;axon guidance;axonal pathfinding;Behavioral;Binding;Binding Proteins;Biochemical;Biological Assay;Complex;Cues;Data;Defect;Development;Disease;domain mapping;Embryonic Development;Etiology;Evolution;experimental study;Family;Family member;fly;Functional disorder;gain of function;Gene Family;Growth Cones;Human;improved;In Vitro;in vivo;Individual;Injury;insight;interdisciplinary approach;Invaded;knockout animal;Knockout Mice;Ligand Binding;Ligand Binding Domain;Ligands;Limb Bud;Logic;loss of function;Mediating;Mediator;member;Mesenchymal;Mesenchyme;Methods;Molecular;Motor;Motor Neurons;mouse genetics;Mus;Nature;Nematoda;neogenin;Nerve;Nerve Regeneration;Nervous System;neural circuit;neural network;Neural tube;Neuroanatomy;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;neurotransmission;novel;novel therapeutic intervention;NTN1 gene;Organism;Orphan;Output;paralogous gene;Pattern;Peripheral;pharmacologic;Phenotype;Process;Proteins;receptor;Receptor Gene;repaired;Reporting;Research;response;Role;Sensory;Sensory Ganglia;Series;Shapes;Signal Pathway;Signal Transduction;Specificity;Spinal;Spinal Ganglia;Subgroup;Tertiary Protein Structure;Testing;Therapeutic;Tissues;Vertebrates;Work

PROJECT_TITLE: Axon guidance through the bifunctional cue WFIKKN2 and its receptors

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Contraception/Reproduction;Estrogen;Genetics;Human Genome;Infertility;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The proposed research addresses the molecular origins of female reproductive aging, which impacts fertility, endocrine function, and overall health. We will test the hypothesis that ovarian aging is fueled by damaged DNA in the oocyte which stimulates an inflammatory response in the surrounding somatic follicular cells that is further amplified by spatial cues within the broader microenvironment. This project provides a novel paradigm for female reproductive aging, a major reproductive transition, and thus aligns with NICHD priorities.

PI_NAMEs: DUNCAN, FRANCESCA E. (contact);GERTON, JENNIFER L

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Acceleration;Address;advanced maternal age;Age;age acceleration;age related;age related changes;Aging;aging mechanism;Aneuploidy;Architecture;Area;Binding;Biology;bone;Brain;cell type;Cells;Chromosomes;Chronic;Clinical;Complex;Congenital Abnormality;Cues;Data;Delayed Childbearing;detection method;Deterioration;Development;DNA;DNA Damage;drivers of aging;egg;Endocrine;Environment;Estrogens;Event;evidence base;Exhibits;Female;female reproductive system;Fertility;Fetal Development;Fibrosis;Gap Junctions;Gene Expression Profile;Genome;genome integrity;Genome Stability;Genomic Instability;Genotoxic Stress;Germ Cells;Goals;Gonadal Hormones;Gonadal structure;Grant;granulosa cell;hallmarks of aging;Health;healthspan;Heart;Human body;Immune;Immune response;improved;Infertility;Inflammaging;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;Innate Immune System;intercellular communication;Intervention;Laboratories;life span;Link;Maintenance;Medical;Menopause;Modeling;Molecular;molecular modeling;Mus;National Institute of Child Health and Human Development;novel;Nuclear;Oocytes;Oranges;Outcome;Ovarian;Ovarian aging;Ovarian Granulosa Cell;Ovary;Pathway interactions;Pattern;Physiological;Process;Production;reproductive;reproductive function;reproductive longevity;reproductive senescence;reproductive tract;Research;Research Priority;response;Role;Signal Transduction;single-cell RNA sequencing;Somatic Cell;Source;spatiotemporal;Spontaneous abortion;Sterility;Stimulator of Interferon Genes;temporal measurement;Testing;Therapeutic Intervention;Tissues;transcriptomics;Woman

PROJECT_TITLE: Oocyte genomic instability as a driver of the aging ovarian innate immune response

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CORAL GABLES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative We develop a comprehensive framework and scalable open source software for machine learning of big omic-data using super greedy tree base learners.

PI_NAMEs: ISHWARAN, HEMANT  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: base;Big Data;classification trees;Computer software;Data;Data Analyses;Machine Learning;National Institute of General Medical Sciences;open source;Performance;regression trees;Research Personnel;Structure;Survival Analysis;Time;Trees;unsupervised learning

PROJECT_TITLE: Super Greedy Trees

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Fungal infections affect an estimated 300 million people annually, causing considerable morbidity and mortality around the globe. Unfortunately, invasive fungal infections have mortality rates that are considerably higher than many other infections with current antifungal drugs. The goal of this project is to develop a novel class of antifungal drug candidates for further pre-clinical development to address this clinical need.

PI_NAMEs: KRYSAN, DAMIAN J (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Acetate-CoA Ligase;Acetyl Coenzyme A;Active Sites;Address;Adenosine Monophosphate;Affect;anti-cancer;anti-fungal agents;Anti-Infective Agents;Aspergillosis;ATP Citrate (pro-S)-Lyase;Azoles;Bacterial Meningitis;Binding;Biochemical;Biological Assay;cancer cell;Candida;Candida albicans;Case Series;Cellular Assay;Chemistry;Clinical;Complement;Complex;Cryptococcal Meningitis;Cryptococcus;Cryptococcus neoformans;Crystallization;Death Rate;design;Development;drug candidate;Enzymes;Esters;fungicide;fungus;Fusarium;Genetic study;Goals;high throughput screening;Human;In Vitro;in vitro activity;in vivo;Infection;inhibitor;interdisciplinary approach;Lead;Libraries;Life;Link;Mammals;meter;Molds;Morbidity - disease rate;mortality;Mycoses;nanomolar;novel;Organ;pathogen;pathogenic fungus;Patients;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacopoeias;Plants;Polyenes;preclinical development;Roentgen Rays;Saccharomyces cerevisiae;scaffold;screening;Series;small molecule;small molecule inhibitor;Source;Structure;Testing;Toxic effect;X-Ray Crystallography

PROJECT_TITLE: Discovery and optimization of antifungal acetyl CoA synthetase inhibitors

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Obesity increases risk for a number of debilitating chronic disease, yet we have made little progress in developing treatments for effective long-term, non-surgical weight loss. Leptin is a hormone released from white fat and can signal weight gain. This proposal will investigate how leptin acts at multiple areas in the brain to inhibit food intake in response to situation in which energy intake has exceeded energy expenditure.

PI_NAMEs: HARRIS, RUTH B (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;Adipose tissue;Affect;Anatomy;Animals;Area;Body fat;Body Weight decreased;Brain;Cell Nucleus;Cells;Cholecystokinin;Cholera Toxin;Chronic;Chronic Disease;Data;Development;Diet;diet-induced obesity;Dose;Eating;energy balance;Energy Intake;Energy Metabolism;experimental study;Failure;Fatty acid glycerol esters;Feedback;feeding;Feeding behaviors;Food;Gene Modified;High Fat Diet;hindbrain;Hormones;Human;Hypothalamic structure;Impairment;In Situ Hybridization;Individual;information processing;Infusion procedures;insight;Intake;Investigation;Lateral;Leptin;leptin receptor;Liquid substance;Literature;Maintenance;Mediating;Modeling;Mus;neural;neural network;neurochemistry;Neurons;Neuropeptides;Nucleus solitarius;Obesity;obesogenic;parabrachial nucleus;paraventricular nucleus;Pathologic;Pathway interactions;Peripheral;pharmacologic;Phenotype;Physiological;Physiological Processes;prevent;Prosencephalon;Rattus;receptor;Receptor Activation;Regulation;Research;response;Risk;Satiation;Signal Transduction;Structure of nucleus infundibularis hypothalami;Structure of paraventricular nucleus of thalamus;Synapses;synergism;System;Testing;Tracer;Viral;Weight;Weight Gain

PROJECT_TITLE: Leptin in the VMH and energy balance

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: MD

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY

ORG_STATE: NY

PHR: Project Narrative Given parks’ importance for community engagement, vibrancy and wellbeing, we will implement a community engaged, human-centered design-driven intervention that empowers and capacitates stakeholders in  predominantly Black and Latino communities to design and implement health and social strategies in newly  renovated parks as a way to enhance the social environment of neighborhoods. We will determine the impact of  this intervention on community-level health-related quality of life and mental health. This innovative study will  inform new models of community engagement, community development and park-based programs and  policies to promote population wellbeing and reduce health disparities.

PI_NAMEs: HUANG, TERRY T-K (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Adult;Anxiety;Belief;Black race;built environment;Capital;Characteristics;Cities;City Government;Climate;Collaborations;Communication;Communities;Community Developments;community engaged intervention;community engaged research;community engagement;Community Health;community intervention;Community Networks;community organizations;Community Participation;community partners;Complement;Consolidated Framework for Implementation Research;COVID-19;Cross-Sectional Studies;depressive symptoms;design;Dimensions;effectiveness/implementation hybrid;empowerment;Equity;Evaluation;follow-up;Fostering;Future;Goals;Grant;Health;Health behavior;Health Benefit;health related quality of life;human centered design;implementation evaluation;improved;Incentives;Individual;informant;Infrastructure;innovation;Intervention;intervention effect;Intervention Studies;Intervention Trial;Interview;Investments;Knowledge;Latino;Leadership;Loneliness;Low income;Marketing;Measures;Mediating;Mental Depression;Mental Health;Methodology;Modeling;multidisciplinary;Music;Neighborhoods;New York City;Outcome;Outcome Study;perceived stress;Perception;Personal Satisfaction;Physical activity;Policies;Population;population health;Positioning Attribute;primary outcome;Problem Solving;Process;programs;prospective test;prototype;Qualitative Research;Randomized;Readiness;Recreation;Reduce health disparities;Research;Resources;Safety;Sampling;Self Efficacy;Services;Shapes;Sleep;social;social cohesion;Social Environment;Social Interaction;social interventions;Social Network;social relationships;Stress;Surveys;Testing;therapy design;tool;Urban Community;Work

PROJECT_TITLE: Community-Engaged Intervention to Optimize the Impact of RenovatedNeighborhood Parks on Community Wellbeing


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Mental Health;Primary Health Care;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE (PUBLIC HEALTH STATEMENT) Alcohol Use Disorder (AUD) often worsens Intimate Partner Violence (IPV) and both cause significant negative health impact. We propose to test a combination of two behavioral interventions, motivational interviewing (MI) and behavioral couples therapy (BCT), which were shown to be acceptable, feasible and have preliminary efficacy in our previous pilot study. If this larger study, delivered by primary care nurses, also shows that the intervention is effective, it can provide an effective, low-cost way to address the problems of IPV and AUD, both in the United States and globally.

PI_NAMEs: ACHARYA, BIBHAV ;EKSTRAND, MARIA L. (contact);KRISHNAMACHARI, SRINIVASAN

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Adherence;Aggressive behavior;Alcohol consumption;alcohol use disorder;Alcohols;anger management;Asia;Attention;Automobile Driving;Behavior;Behavior Therapy;Behavioral;Breathalyzer Tests;Clinic;Clinical;cognitive process;cohort;Collaborations;Combined Modality Therapy;Communication;conflict resolution;contingency management;Control Groups;coping;cost;Couples;Couples Therapy;Critical Pathways;Cues;Data;disorder risk;Education;Effectiveness of Interventions;Event;evidence base;experience;Family Violence;follow-up;Funding;Future;global health;Goals;group intervention;Health;Health Professional;Health system;Heavy Drinking;high risk behavior;HIV;Home;Husband;Impairment;improved;India;Individual;Intention;Intervention;intervention refinement;Interview;intimate partner violence;Intoxication;Marital Relationships;Maternal Health;Measures;Mediation;Mental Health;mental training;Meta-Analysis;Methods;Modeling;motivational enhancement therapy;Nurses;Outcome;Participant;Perception;perpetrators;Pilot Projects;pilot test;Population;primary care clinic;primary care setting;primary health center;Primary Nursing Care;primary outcome;Problem Solving;Process;Protocols documentation;Psychologist;Public Health;Questionnaires;Randomized;Randomized, Controlled Trials;Recording of previous events;reduced alcohol use;Reporting;Research;Research Infrastructure;Resource-limited setting;Risk;Risk Taking;Role;scale up;secondary outcome;Services;Sex Behavior;sexual violence;Sexually Transmitted Diseases;Site;skills;skills training;social cognitive theory;social stigma;successful intervention;suicidal risk;Suicide attempt;Target Populations;Testing;theories;Therapeutic Intervention;Training;treatment as usual;treatment comparison;Treatment Efficacy;treatment group;Trust;United States;United States National Institutes of Health;Violence;violence perpetration;Vulnerable Populations;Wife;Woman

PROJECT_TITLE: A combined motivational interviewing and behavioral couples therapy intervention to reduce intimate partner violence and alcohol use in South India


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Our new preclinical adRP model could also be useful for testing of future gene- and drug-based therapies. The proposed research is innovative, as it introduces new methods and model systems as the initial steps of a precision medicine approach toward developing adRP treatment. These methods are also potentially adaptable to therapies based on targeting DNA sequences of genes linked to other dominant disorders.

PI_NAMEs: TSANG, STEPHEN H (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Ablation;Acceleration;Address;Alleles;American;autosome;bench-to-bedside translation;Biological Markers;Biological Models;Biological Process;Blindness;caucasian American;cDNA delivery;Cell Cycle;Cell Line;Cells;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;comparative efficacy;Complementary DNA;cost;cost effective;CRISPR therapeutics;design;Disease;DNA Sequence;dominant genetic mutation;effective therapy;Effectiveness;efficacy evaluation;efficacy validation;Engineering;Episome;Future;G2 Phase;gene augmentation therapy;Gene Silencing;gene-editing approach;Genes;Guide RNA;Health;Heterozygote;Human;humanized mouse;improved;In Vitro;in vivo;Inherited;Injections;innovation;Left;Lentivirus Vector;Light;Link;Mediating;Methods;Modeling;Modification;Molecular;mouse model;Mus;mutant;Mutation;novel;Nucleotides;Organoids;Pathology;Patients;Pharmaceutical Preparations;phase I/IIa trial;Phototransduction;pre-clinical;Pre-Clinical Model;precision medicine;preclinical evaluation;prime editing;promoter;Proteins;repaired;Research;Resistance;Retina;Retinitis Pigmentosa;rho;Rhodopsin;RNA Interference;RNA Sequences;S phase;Safety;screening;Single Nucleotide Polymorphism;Specificity;Supplementation;System;Techniques;Technology;Testing;Therapeutic;therapeutic genome editing;Time;tool;Toxic effect;Transcription Initiation Site;Transgenes;Translational Research;Translations;Treatment Efficacy;treatment strategy;United States;Validation;Variant;Viral Vector

PROJECT_TITLE: Gene Editing and Silencing in Phototransduction

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Cancer;Brain Disorders;Cancer;Coronaviruses;Coronaviruses Therapeutics and Interventions;Data Science;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Liver Cancer;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Rare Diseases

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE The goal of this proposal is to address some fundamental issues in leveraging the emerging omics and artificial intelligence to discover novel compounds. It will apply the methods into real drug discovery studies including the discovery of inhibitors for liver cancer and SARS-CoV-2, the discovery of small molecules to control cell reprograming, and the generation of new analogs for repurposed drugs.

PI_NAMEs: CHEN, BIN  (contact);ZHOU, JIAYU

PROJECT_TERMS: 2019-nCoV;Address;Advanced Development;analog;Artificial Intelligence;artificial intelligence model;Biological;Biological Assay;Brain;Case Study;Cell Line;Cell Reprogramming;Cells;Chemical Structure;computer framework;cost;Data;Data Science;Data Set;deep learning model;deep reinforcement learning;Development;Diffuse intrinsic pontine glioma;Disease;drug discovery;drug efficacy;drug repurposing;Drug Screening;experience;Fingerprint;Gene Expression;Gene Expression Profile;Generations;Genes;genetic signature;Goals;Graph;graph neural network;Heterogeneity;improved;In Vitro;inhibitor;Knowledge;Label;lead optimization;Learning;Libraries;Liver Fibrosis;Machine Learning;machine learning method;machine learning model;Magic;Malignant neoplasm of liver;Medicine;Methods;Modeling;Molecular;Molecular Disease;multi-task learning;Mycophenolic Acid;novel;novel therapeutics;overexpression;Penetration;Performance;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pre-Clinical Model;Primary carcinoma of the liver cells;Property;Proteins;Publishing;SARS-CoV-2 inhibitor;Scientist;screening;shot learning;small molecule;Solubility;Structure;Technology;Testing;therapeutic candidate;Toxic effect;Training;virtual;Work

PROJECT_TITLE: virtual compound screening using gene expression

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: ALBANY

ORG_NAME: STRATTON VETERANS ADMIN MEDICAL CENTER

PHR: Limb amputation leads to abnormal sensory-motor cortex reorganization, which is associated with phantom limb pain (PLP). Current therapies have aimed to restore organization in the motor cortex with little focus on sensory processing, which is also crucial for effective movement. Their efficacy remains unclear. We hypothesize that restoring somatosensory cortex organization will be vital in reducing PLP. Sensory loss correlates with a small or delayed evoked potential in brain signals recorded from the scalp. We will develop and test a novel noninvasive non-pharmacological therapy which works by training a person to increase their somatosensory evoked potentials. The potentials are elicited via the mirror effect, i.e., stimulating the intact limb while viewing it in a mirror, to evoke a sensation in the phantom limb. We expect that directly training these evoked potentials will help restore effective sensory organization for the missing limb and reduce PLP, beyond the extent now possible. Future studies will explore this approach in other chronic pain conditions.

PI_NAMEs: BRANGACCIO, JODI ANN (contact)

PROJECT_TERMS: Affect;American;Amputation;Analgesics;Animals;Area;arm;arm function;Attention;Back Pain;Blinded;Brain;brain machine interface;Central Nervous System Diseases;central pain;Chronic;chronic painful condition;Clonus;Cognition;Complement;conditioning;Contralateral;Control Groups;Data;Deep Brain Stimulation;Dependence;Development;Dimensions;Discrimination;Disease;Drug Addiction;Electroencephalography;Equipment and supply inventories;Esthesia;Evoked Potentials;expectation;Extensor;Feedback;follow-up;Foot-drop;Future;grasp;H-Reflex;hand dysfunction;Home;Human;Impairment;improved;innovation;interest;Intervention;Job loss;Leg;limb amputation;limb loss;Limb structure;Locomotion;Measures;method development;Motor Cortex;Motor Evoked Potentials;Movement;Nervous System;Neuronal Plasticity;Nonpharmacologic Therapy;novel;novel therapeutics;Operant Conditioning;Outcome;Pain;Pain Measurement;pain reduction;Pain Research;pain sensation;Painless;Peripheral;Persons;Phantom Limb;Phantom Limb Pain;Pharmaceutical Preparations;Physiology;Protocols documentation;Psychological reinforcement;Quality of life;Randomized;Recovery of Function;Research;response;restoration;Scalp structure;Sensory;sensory cortex;Sensory Physiology;Signal Transduction;Site;social;Soleus Muscle;somatosensory;Somatosensory Cortex;Somatosensory Evoked Potentials;Spinal cord injury;Stimulus;Stroke;success;System;Tactile;tactile stimulation;Telemedicine;Testing;Training;Transcranial magnetic stimulation;Treatment Efficacy;Veterans;visual feedback;Walking;West Haven-Yale Multidimensional Pain Inventory;Work

PROJECT_TITLE: Operant conditioning of sensory evoked potentials to reduce phantom limb pain

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: DA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Cerebrovascular;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Narrative We propose to leverage a suite of the BRAIN Initiative tools to investigate the effect of top-down brain signals that control high-level cognitive functions on noninvasive imaging readouts. These studies will be conducted in the context of spontaneous (“resting-state”) and task-induced brain activity under healthy conditions and intoxication with cocaine. This project will deliver a stronger physiological foundation for the interpretation of fMRI signals in healthy individuals, examine the effects of cocaine on neuronal and hemodynamic brain activity, and generate further hypotheses about the ways in which substance exposure may affect fMRI readouts.

PI_NAMEs: DEVOR, ANNA  (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Acetylcholine;Acute;Affect;Anesthesia procedures;Animals;Arousal;Attention;awake;blood oxygen level dependent;blood oxygenation level dependent imaging;Blood Vessels;Brain;Brain imaging;BRAIN initiative;Brain region;cerebral hemodynamics;Cerebrovascular Circulation;Cerebrum;Chronic;Cocaine;cocaine exposure;cognitive function;Conscious;Consumption;Decision Making;Dilator;Dopamine;drug of abuse;Electrophysiology (science);Energy Metabolism;Evaluation;experimental study;Exposure to;foot;Foundations;frontal lobe;Functional Magnetic Resonance Imaging;Generations;hemodynamics;high resolution imaging;Human;human subject;Image;imaging study;Imaging technology;Individual;Induced Neurons;inhibitory neuron;Intoxication;Knowledge;Learning;Measurable;Measurement;Measures;Mediating;Memory;Metabolic;metabolic rate;Microscope;Microscopic;Modality;model organism;Mus;Neuromodulator;Neurons;neuropeptide Y;neuroregulation;neurotransmission;Neurotransmitters;neurovascular;Nitric Oxide;non-invasive imaging;Norepinephrine;Optical reporter;Optics;optogenetics;Partial Pressure;Pharmaceutical Preparations;pharmacologic;Physiological;Property;Prostaglandins;Psychiatrist;Psychologist;Pyramidal Cells;Reporter;Research;response;Rest;Rewards;Signal Transduction;Somatosensory Cortex;Substance of Abuse;System;Testing;Time;tool;two photon microscopy;two-photon;vasoconstriction;Vasodilation

PROJECT_TITLE: Effects of intrinsic and drug-induced neuromodulation on functional brain imaging

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Diseases related to pulmonary and critical care medicine (PCCM) remain among the leading causes of morbidity and mortality, nationally; however, recent advances in molecular and cellular biology, immunology, clinical intervention and biomedical informatics are unleashing the power of scientific discovery to impact health. The UCLA PCCM Training Program (PCCMTP) is dedicated to mentored, interdisciplinary team-based training of a new generation of academic and industry leaders in basic, translational and clinical research. By deploying facilities and resources of renowned multidisciplinary mentor faculty, we will fulfill the program mission of training a cadre of investigators who will discover novel underlying basic principles of PCCM-related diseases and translate these discoveries to improve health.

PI_NAMEs: DUBINETT, STEVEN M. (contact);GANZ, TOMAS

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TITLE: UCLA Pulmonary and Critical Care Medicine Training Program

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Serious Mental Illness

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Obsessive-compulsive disorder (OCD) is a neuropsychiatric condition that causes enormous human suffering and cost to society. Our goal is to rapidly learn more about the genetics of this disorder and how genes and environment might act and interact to alter disease risk. We propose to do this by collecting a new, large, ancestrally-diverse and well-phenotyped sample of OCD cases followed by detailed genomic analyses.

PI_NAMEs: STORCH, ERIC A. (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Address;Area;Argentina;autism spectrum disorder;Bioethics;Biological;Biology;Bipolar Disorder;Brazil;Chile;Chronic;Clinic;Clinical;cohort;Cohort Studies;Collaborations;Colombia;comorbidity;cost;cost effective;Data;design;Detection;Diagnosis;Dimensions;Disease;disorder risk;Disparity;DNA;Ecuador;Environment;Equity;Etiology;European ancestry;follow-up;Functional disorder;Funding;Future;Genes;Genetic;genetic analysis;genetic architecture;Genetic Diseases;Genetic study;Genome Mappings;genome wide association study;genome-wide;genomic locus;Genomics;Genotype;Goals;health disparity;high risk;Human;improved;Individual;Knowledge;Latin America;Latin American;Latinx;Learning;Linkage Disequilibrium;Maps;Measures;Mental disorders;Mental Health;Meta-Analysis;Mexico;neuropsychiatry;novel;Obsessive-Compulsive Disorder;Online Systems;Outcome;Pathway interactions;Patients;Performance;Phenotype;phenotypic data;polygenic risk score;Population;precision medicine;Prevention strategy;psychiatric genomics;Public Health;recruit;Reduce health disparities;Risk;risk variant;Saliva;Sample Size;Sampling;Schizophrenia;Science;screening;Severities;societal costs;Societies;Specialist;Structure;Symptoms;Testing;Training;Variant;Work;working group

PROJECT_TITLE: 2/2 TRANS-ANCESTRY GENOMIC ANALYSIS OF OBSESSIVE COMPULSIVE DISORDER


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Caregiving Research;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Health Services;Infectious Diseases;Neurodegenerative;Patient Safety;Prevention

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE Visitation bans in nursing homes were a major policy intervention in response to the COVID-19 pandemic, yet there is limited knowledge regarding their effectiveness in COVID-19 prevention or the unintended adverse effects on residents and care practices in nursing homes. By analyzing unique visitation ban data at the state and facility level, this study will provide timely information on both the positive and negative effects of visitation bans, with a special focus on residents with Alzheimer's Disease & Related Dementias, which will help policymakers better understand the full impact of this controversial mitigation measure. This is especially policy- relevant currently, because many states have passed or are considering passing laws to ensure visitation rights among nursing home residents, even during a pandemic.

PI_NAMEs: XU, HUIWEN  (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;Adverse effects;Adverse event;adverse event risk;adverse outcome;Affect;Alzheimer's disease related dementia;Behavior;Caregivers;Caring;case control;Cessation of life;Characteristics;Communities;Commuting;County;COVID-19;COVID-19 mortality;COVID-19 pandemic;COVID-19 prevention;Data;Data Set;design;Effectiveness;effectiveness evaluation;Ensure;falls;Family;Family member;Focus Groups;Friends;functional decline;future pandemic;General Population;Group Interviews;Health;Health Personnel;Home visitation;hospice environment;Hospitalization;Hour;Individual;Infection;Infection Control;infection rate;informal care;informal caregiver;Intervention;Knowledge;Laws;Lifting;Link;Masks;Measures;Medicare claim;Mental Depression;Methods;Modeling;Moods;Nurses' Aides;Nursing Homes;Ohio;Outcome;pandemic disease;pandemic response;Pathway interactions;Physical Function;Physicians;Policies;Policy Maker;prevent;Published Comment;Recommendation;response;Rights;routine care;SARS-CoV-2 infection;SARS-CoV-2 transmission;satisfaction;Social isolation;Surveys;Time;transmission process;Travel;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;Variant;viral transmission;Visit;Work

PROJECT_TITLE: Nursing homes' visitation bans during the COVID-19 pandemic: Effectiveness and consequences.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Post-Traumatic Stress Disorder (PTSD);Rehabilitation;Substance Misuse;Telehealth

PHR: Project Narrative Posttraumatic stress disorder (PTSD) affects 30-60% of alcohol use disorder (AUD) treatment patients, and those AUD patients with comorbid PTSD have poorer treatment prognosis than those without PTSD. However, there are very few PTSD-focused treatments available for AUD patients with comorbid PTSD that may reduce their PTSD symptom burden and improve AUD treatment outcomes. This project aims to fill that gap by testing the impact of a novel mobile health application combined with brief clinical support (PTSD Coach app + brief support) compared to enhanced usual care (EUC) on PTSD and AUD recovery outcomes among patients with comorbid PTSD and AUD in residential addictions treatment.

PI_NAMEs: BOHNERT, KIPLING M (contact)

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: addiction;Address;Adherence;Adult;Affect;Aftercare;alcohol abuse therapy;Alcohol consumption;alcohol intervention;alcohol seeking behavior;alcohol use disorder;Alcohols;Area;Cessation of life;Clinical;Cocaine;Communities;comorbidity;coping;cost;Data;Dose;evidence base;Female;financial incentive;follow-up;Frequencies;Gender;Goals;handheld mobile device;Health Services Accessibility;Health Status;Impairment;Improve Access;improved;inclusion criteria;Individual;innovation;Intervention;intervention effect;male;Mediator;men;mhealth interventions;Mobile Health Application;National Institute on Alcohol Abuse and Alcoholism;novel;Outcome;Participant;patient screening;Patient-Focused Outcomes;Patients;Population;Post-Traumatic Stress Disorders;prevent;Prognosis;psychoeducation;psychological symptom;psychosocial;Psychotherapy;Public Health;Randomized;Recovery;Relapse;Research;Residential Treatment;Sampling;Self Efficacy;Self Management;Severities;standard care;Strategic Planning;stress related disorder;Structure;substance use;Substance Use Disorder;Symptom Burden;symptomatic improvement;Symptoms;Technology;Testing;Time;tool;treatment as usual;treatment effect;Treatment outcome;United States;Waiting Lists;Woman;women's treatment;Work

PROJECT_TITLE: Testing a PTSD m-Health Intervention to Improve Alcohol Treatment Outcomes

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA(03)-3]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Bacterial corneal infections (keratitis) caused by the bacteria Staphylococcus aureus often result in devastating, vision-threatening complications and significantly contributes to the burden of world blindness. Currently our ability to adequately treat this disease is limited by the lack of understanding of how S. aureus initiates and maintains infection in this unique biologic niche. This project addresses this knowledge gap through a novel, comprehensive approach for the identification and validation of the key bacterial drivers of S. aureus keratitis.

PI_NAMEs: WOZNIAK, RACHEL A F (contact)

PROJECT_TERMS: Address;Adherence;Antibiotic Resistance;Antibiotics;Area;Attention;Automobile Driving;Bacteria;Bacterial Adhesins;Bacterial Proteins;Binding;Binding Proteins;Bioinformatics;Biological;Biological Assay;Blindness;Blinking;Body System;Cells;Cellular Assay;Clinical;Collagen;comparative genomics;Cornea;corneal epithelium;cytokine;cytotoxicity;Data;Disease;drug discovery;Endocarditis;Enterotoxins;Environment;Epithelial Cells;Evaluation;Eye Infections;Film;fitness;Genes;Genetic;Genetic Determinism;Genome;genome sequencing;Genomic approach;Genomics;Goals;Healthcare;Hemolysin;human pathogen;Immune;Immune Evasion;Immune response;Immune system;Immunohistochemistry;In Vitro;in vivo;in vivo Model;Individual;Infection;Infectious Skin Diseases;innovation;interest;Invaded;Keratitis;Knowledge;Laboratories;Link;mastitis;Mediating;mouse model;mutant;novel;novel strategies;novel therapeutics;Nutrient;ocular surface;Osteomyelitis;Pathogenesis;Pathogenicity Island;Physiological;Pilot Projects;Pneumonia;prospective;Proteins;rational design;Regulation;Research;Role;Sepsis;Severity of illness;Site;Staphylococcus aureus;Staphylococcus aureus infection;Surface;Therapeutic;Therapeutic Intervention;Time;Tissues;tool;Toxic effect;Toxin;transcriptome;transcriptome sequencing;transcriptomics;transposon sequencing;Validation;virtual;Virulence;Virulence Factors;Vision;whole genome;Work

PROJECT_TITLE: Virulence of Staphylococcus aureus Corneal Infections


PHR: The autonomic nervous system innervates the pancreatic islet and thus helps regulate glucose metabolism, but little is known about the local mechanisms of how nerves control hormone secretion from pancreatic endocrine cells. In this project we will visualize, manipulate, and record from nerves that receive and send signals to the pancreas and test how these nerves impact pancreatic hormone secretion. The results will contribute to our basic understanding of how islet biology and glucose metabolism are influenced by autonomic nerves, which is important to guide pre-clinical neuromodulatory studies to improve islet function in diabetes.

PI_NAMEs: CAICEDO, ALEJANDRO  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Affect;afferent nerve;Afferent Neurons;Anatomy;autonomic nerve;Autonomic nervous system;Axon;Beta Cell;Biology;Blood Glucose;blood glucose regulation;Brain;Brain Stem;Cell Physiology;Cells;Central Nervous System;cholinergic;Communication;Data;Development;Diabetes Mellitus;Disease;dorsal motor nucleus;Duodenum;Eating;Efferent Neurons;Electric Stimulation;Electrodes;Endocrine;Enteral;Feedback;Ganglia;Genetic;genetic approach;Genetic Recombination;Glucagon;glucose metabolism;glucose tolerance;Goals;Hormone secretion;improved;In Situ;in vivo;Insulin;insulin secretion;islet;Islet Cell;Islets of Langerhans;Knowledge;Label;Life;Logic;Maps;Measures;Mission;Modeling;Nerve;nerve supply;neural circuit;Neural Pathways;Neuroanatomy;neuronal circuitry;Neurons;neuroregulation;Nodose Ganglion;novel;novel strategies;Nucleus solitarius;optogenetics;Organ;Pancreas;Pancreatic Endocrine Secretion;Pancreatic Hormones;pancreatic juice;Peripheral;Physiological;Plasma;Population;pre-clinical;prevent;Property;Protocols documentation;Publishing;Regulation;Research;response;Role;Sensory;Signal Transduction;Stress;System;Testing;tool;United States National Institutes of Health;Visceral;Visualization;Work

PROJECT_TITLE: The functional impact of pancreatic islet innervation

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Women's Health Research

ORG_CITY: TEMPE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The human sex chromosomes hold unique signatures of our evolutionary history, and contribute to sex-biased gene expression that affects human health. This project aims to develop methods that improve identification of variation on the sex chromosomes, utilize patterns of variation across the sex chromosomes and non-sex chromosomes to characterize human demography, and investigate sex-biased gene expression across populations.

PI_NAMEs: WILSON, MELISSA A (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Accounting;Address;Affect;Africa;African;Animals;autosome;Biology;Chromosomes;Collaborations;Demography;Development;Disease;Diverse Workforce;Evolution;Gene Expression;gene expression variation;genome-wide;genomic variation;Genomics;Health;Human;Human Genome;improved;instructor;Learning;Link;Macaca mulatta;Medical;Methodological Studies;Methodology;Methods;migration;Mitochondrial DNA;novel;Organ;Outcome Study;Pattern;Placenta;Ploidies;Population;Population Dynamics;Population Study;Pregnancy Outcome;Recording of previous events;Research;Research Project Grants;Self Efficacy;sex;Sex Bias;Sex Chromosomes;skills;Students;Testing;Tissues;tool;Training;Variant;Work;X Chromosome;X Inactivation;Y Chromosome

PROJECT_TITLE: Population dynamics and medical consequences of sex chromosome evolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Lung;Lung Cancer

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Acquired drug resistance limits the survival of EGFR mutant lung cancer patients treated with EGFR targeted therapies. In this project, we will investigate non-genomic tumor cell intrinsic and microenvironmental mechanisms contributing to osimertinib resistance.

PI_NAMEs: HATA, AARON N (contact);PIOTROWSKA, ZOFIA

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: acquired drug resistance;Automobile Driving;Biological Assay;Biopsy;Blood;BRAF gene;Cancer Patient;Cells;Clinical;Clinical Research;clinically relevant;cohort;Development;DNA Sequence Alteration;drug resistance development;effective therapy;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Fibroblasts;Future;Gene Expression Profile;Generations;Genomics;Histologic;Immune;immune activation;improved;Infrastructure;innovation;Investigation;Laboratories;liquid biopsy;Malignant neoplasm of lung;Malignant Neoplasms;Modeling;Molecular Analysis;molecular targeted therapies;mutant;Mutation;neoplastic cell;new therapeutic target;non-genomic;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Patient Care;Patients;Pharmaceutical Preparations;Plasma;Population Heterogeneity;pre-clinical;Quality of life;relapse patients;Resistance;resistance mechanism;resistance mutation;response;RNA;Role;standard of care;Stromal Neoplasm;targeted treatment;therapy development;Tissues;tumor;Tumor Cell Line;tumor heterogeneity;tumor microenvironment;Tumor Tissue

PROJECT_TITLE: Non-genomic resistance mechanisms in EGFR-mutant lung cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Mental Health;Neurosciences;Pediatric;Sleep Research;Substance Misuse;Underage Drinking

ORG_CITY: PISCATAWAY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Narrative College students often misuse alcohol and report poor sleep. These habits are solidified in young adulthood and can contribute to long-term mental and physical health issues. This proposal seeks to understand individual differences in how alcohol misuse and poor sleep interact to identify biomarkers that may reduce risk for alcohol use disorders and other related health conditions.

PI_NAMEs: BUCKMAN, JENNIFER F. (contact);SPAETH, ANDREA MARIE

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: actigraphy;Acute;addiction;Affect;alcohol consequences;Alcohol consumption;alcohol effect;alcohol misuse;alcohol research;alcohol response;alcohol risk;alcohol risk reduction;alcohol testing;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Behavior;behavior influence;Behavioral;binge drinking;Biological Markers;biomarker identification;Blood Circulation;Cardiovascular Physiology;Cardiovascular system;Chronic;college;Consumption;Data;design;Development;diaries;Dimensions;Disease;Dissociation;drinking;Ensure;Environment;Event;Grain;Habits;Harm Reduction;Health;Home;improved;improvement on sleep;Inadequate Sleep Hygiene;indexing;Individual;Individual Differences;individual variation;innovation;Intoxication;Life;Link;Longitudinal Studies;maladaptive behavior;Maps;Measurable;Measures;Mental disorders;Mental Health;Parents;Participant;Patient Self-Report;Pattern;Persons;physical conditioning;Physiological;Physiology;Play;Polysomnography;poor sleep;Procedures;Protocols documentation;psychologic;Public Health;rapid eye movement;Recovery;recruit;relapse risk;REM Sleep;Reporting;Research;response;Risk;Risk Factors;Role;Saliva;secondary analysis;Sleep;Sleep Architecture;sleep behavior;Sleep Deprivation;Sleep disturbances;sleep pattern;sleep physiology;sleep quality;sleep quantity;Slow-Wave Sleep;stem;Stress;Test Result;Testing;Time;university student;wearable device;young adult

PROJECT_TITLE: Characterizing individual differences in the reciprocal relationship between sleep deprivation and binge drinking within the context of college life

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative Macrophage-based cancer immunotherapy represents a new class of very promising cancer therapy. This study aims to develop strategies to promote macrophage-mediated cancer immunosurveillance by breaking macrophage tolerance, and to determine the efficacy and molecular mechanisms of these strategies. Completion of this study should enable a better understanding of the basic principles of cancer development and inspire the invention of effective cancer immunotherapy by exploiting the tumoricidal role of macrophages.

PI_NAMEs: FENG, MINGYE  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Adjuvant;Adjuvant Therapy;anti-cancer;Antineoplastic Agents;B-Lymphocytes;bench-to-bedside translation;Biochemical;Bioinformatics;Biological;Biological Assay;Blocking Antibodies;cancer cell;cancer immunotherapy;Cancer Model;cancer therapy;cancer type;CD47 gene;Cell Communication;Cell surface;Cells;chemotherapy;Clinical Trials;Combined Modality Therapy;CSF1R gene;cytotoxicity;design;Development;Dose;Eating;efficacy evaluation;Engraftment;Excision;FDA approved;Hematopoietic Neoplasms;high throughput screening;Human;immune cell infiltrate;immune checkpoint;Immune Evasion;Immune response;Immune Tolerance;Immunologic Surveillance;Immunologics;Immunotherapy;improved;In Vitro;in vivo;innovation;invention;Investigation;Macrophage;Macrophage Activation;Malignant - descriptor;Malignant Neoplasms;Mediating;Methods;Molecular;mouse model;Natural Killer Cells;neoplastic cell;new combination therapies;novel;novel therapeutics;Paclitaxel;Phagocytes;Phagocytosis;Phenotype;Play;pre-clinical;Pre-Clinical Model;Predisposition;Primary Neoplasm;Process;receptor;Regimen;Regulation;Research Proposals;response;Role;screening;Signal Pathway;Signal Transduction;Site;small molecule;Solid Neoplasm;T-Lymphocyte;targeted agent;Therapeutic;Toxic effect;Treatment Efficacy;treatment response;tumor;Tumor Escape;Tumor stage;Tumor-associated macrophages;tumor-immune system interactions

PROJECT_TITLE: Identifying and engaging a universal adjuvant for breaking macrophage immune tolerance in cancer

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PI_NAMEs: KELLER, COREY J (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Affect;Algorithms;American;Atlases;Axon;Behavior;biophysical model;Brain;brain behavior;Brain Diseases;brain dysfunction;Brain region;Cephalic;Clinic;Clinical;clinical predictors;cognitive control;Complex;Databases;Decision Making;Depressed mood;depressed patient;Development;Disease remission;Double-Blind Method;effective therapy;Electrophysiology (science);Epilepsy;Evoked Potentials;Exhibits;France;Frequencies;frontal lobe;Functional disorder;Future;Goals;Guidelines;Human;Impairment;Implant;improved;Individual;individualized medicine;innovation;insight;Instruction;inter-individual variation;interest;Knowledge;Link;Location;Magnetic Resonance Imaging;Major Depressive Disorder;Maps;Measures;Mental Depression;Mental disorders;Methodology;Methods;Modeling;Nervous System Disorder;neural;neural correlate;Neurons;neuropsychiatric disorder;neuroregulation;novel;Operative Surgical Procedures;Outcome;Parietal;Parietal Lobe;Pathologic;Patients;Pharmaceutical Preparations;Physiology;Population;Prefrontal Cortex;Property;prospective;prospective test;repetitive transcranial magnetic stimulation;Research Proposals;Resistance;response;Scalp structure;Signal Transduction;Specificity;Structure;Techniques;Testing;Time;tool;Work

PROJECT_TITLE: CRCNS US-France Research Proposal: Probing the Dorsolateral Prefrontal Cortex and Central Executive Network for Improving Neuromodulation in Depression


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The proposed project aims to develop predictive biomarkers for relapse following surgery and postoperative systemic therapy in early-stage non-small-cell lung cancer using mass spectrometry-based global and targeted proteogenomic analyses of human lung cancer specimens from clinical trials.

PI_NAMEs: CARR, STEVEN A;GILLETTE, MICHAEL A;GOVINDAN, RAMASWAMY  (contact)

PROGRAM_OFFICER_NAME: HILTKE, TARA

PROJECT_TERMS: Adenocarcinoma Cell;Adjuvant;anaplastic lymphoma kinase;assay development;Assessment tool;Biological Assay;Biological Markers;biomarker identification;cancer cell;Cancer Etiology;cancer genome;cancer recurrence;Center for Translational Science Activities;Cessation of life;Characteristics;chemotherapy;Clinical;Clinical Trials;cohort;Coupled;crizotinib;Data;Data Analyses;Enrollment;Epidermal Growth Factor Receptor;Erlotinib;Excision;exome;Funding;Genome;genomic data;Genomics;Human;immune checkpoint blockade;improved;improved outcome;inhibitor;Intervention Trial;Lung Adenocarcinoma;lymphatic Invasion;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Mass Spectrum Analysis;medical schools;molecular targeted therapies;Multicenter Studies;mutant;Mutation;National Cancer Institute;National Clinical Trials Network;Nivolumab;Nodal;Non-Small-Cell Lung Carcinoma;Operative Surgical Procedures;Outcome;outcome prediction;participant enrollment;Pathway interactions;patient subsets;Patient-Focused Outcomes;Patients;Peptides;Phosphorylation;Platinum;Post-Translational Protein Processing;Postoperative Period;predictive marker;prognostic;Prognostic Factor;Prognostic Marker;prognostic model;programmed cell death ligand 1;programmed cell death protein 1;Proteins;proteogenomics;Proteome;Proteomics;Randomized;randomized trial;Receptor Protein-Tyrosine Kinases;Recurrence;Relapse;relapse prediction;relapse risk;Research Personnel;Resectable;Resected;Risk Factors;risk prediction;Role;Sampling;screening;Specimen;Squamous Cell Lung Carcinoma;standard of care;support network;Systemic Therapy;Testing;Therapeutic Trials;Tissue Sample;Training;transcriptome;transcriptomics;Translating;trial comparing;tumor;Universities;Validation;Visualization;Washington;whole genome;working group

PROJECT_TITLE: Proteogenomic Predictors of Recurrence in Non-small Cell Lung Cancer


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Chronic Pain;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Headaches;Infectious Diseases;Machine Learning and Artificial Intelligence;Mental Health;Migraine;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research;Pediatric;Physical Injury - Accidents and Adverse Effects;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Traumatic Head and Spine Injury

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Chronic pain experienced by children has the potential to persist into adulthood and drive drug addiction, mental health problems and suicidal behavior. The level of pain reported by children who experience headache is immense and likely poorly estimated based on lowered ability of children to articulate symptoms, potential malingering or underreporting of pain symptoms, and extensive variability in physical growth and brain development. Headache is a frequently reported and poorly understood primary and secondary disorder in pediatric subjects. The diverse presentation of headache underscores the potential for distinct mechanisms of headache presentation, thus placing emphasis on tailored treatment options. In the proposed research program, we investigate four phenotypically distinct forms of headache in youth to understand the physiological mechanisms that govern their phenotypic presentation. Taking advantage of a highly diverse and specialized research team in headache research and clinical care, findings will greatly inform the diagnosis and treatment of childhood headache and reduce future pain-related dependencies on healthcare resources.

PI_NAMEs: HOLMES, SCOTT  (contact);LEBEL, ALYSSA A

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Absence of pain sensation;Adolescent;Adult;Age;Articulation;Behavioral;biobehavior;biopsychosocial;Brain;Brain Concussion;Brain region;Central Nervous System;central pain;Characteristics;Child;Childhood;Chronic;Chronic Daily Headaches;Chronic Headaches;chronic pain;chronic painful condition;Classification;Clinical;clinical care;clinically relevant;cohort;Complex;COVID-19;Data;Data Set;deep learning;Dependence;Development;Diagnosis;Disease;Drug Addiction;Elements;Etiology;experience;Female;Frequencies;Future;Genetic;Growth;Headache;Headache Disorders;Health system;Healthcare;individualized medicine;Intervention;Investigation;Learning;Long COVID;Machine Learning;machine learning classifier;male;Malingering;Measures;medical specialties;Mental Health;midbrain central gray substance;Migraine;morphogens;Muslim religion;neuroimaging;Pain;Pain Disorder;Pain management;pain processing;pain rehabilitation;pain symptom;Participant;Patients;Phenotype;Physiological;Physiology;Post-Traumatic Headaches;Predisposing Factor;Prevalence;Problem behavior;programs;PubMed;Refractory;Rehabilitation Centers;Reporting;Research;Resistance;Resolution;Resources;response;Severities;sex;Source;Specificity;suicidal behavior;Symptoms;System;Techniques;Testing;text searching;therapy resistant;Time;treatment optimization;treatment services;Work;Youth

PROJECT_TITLE: Pediatric Chronic Headache and COVID-19: Use of Machine Learning and Biobehavioral Analysis to Classify Headache Mechanism and Optimize Treatment Course.

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: CAMBRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Protein-protein interactions are essential for all biological processes and are often misregulated in disease. This proposal describes an integrative computational and experimental research program to advance the prediction of human protein interactions and the design of new proteins that make selective interactions for use in biological research and pharmacological discovery.

PI_NAMEs: KEATING, AMY E (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Autophagocytosis;Autophagosome;Binding;Binding Proteins;Biological Process;biological research;Biology;cancer cell;Cell Shape;Cell surface;Cellular biology;Cellular Structures;Chemicals;Complex;computer studies;data-driven model;deep learning;design;Detection;Disease;Disease Pathway;experimental study;Family;Goals;Human;human interactome;improved;inhibitor;Invaded;Investigation;Knowledge;Learning;Life;Link;Maps;member;Methods;Modeling;Neoplasm Metastasis;novel therapeutics;paralogous gene;pharmacologic;Play;programs;Proline;Protein Engineering;protein protein interaction;Proteins;Proteome;receptor;recruit;Research;research and development;Role;screening;Signal Transduction;Specificity;Structure;Techniques;Tertiary Protein Structure;transmission process;vasodilator-stimulated phosphoprotein

PROJECT_TITLE: Computational and Experimental Investigation and Design of Protein Interaction Specificity


NIH_SPENDING_CATS: Clinical Research;Pediatric

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE This proposal, entitled Hk Maker Lab 2.0: Inspiring Engineering Design Thinking in Grades 6 – 12 Students and Teachers, focuses on giving middle and high school students opportunities to learn about engineering design and use design to devise solutions to open-ended problems; promotes engineering design thinking and content in the classroom by training middle and high school teachers in engineering design; and will form a cohort of master teachers, who are adept in design and can impart concepts to their fellow teachers. The role of engineering in public health has been made abundantly clear by the COVID-19 pandemic and the associated technical and medical problems that engineers have been called upon to help solve, which demand the skills of a diverse workforce that can creatively meet technical challenges while providing varied views on problems. This project will directly support the development of a diverse, representative, and resilient engineering workforce that will be prepared to solve the most pressing issues in public health and medicine.

PI_NAMEs: KYLE, AARON MATTHEW (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Adopted;Adoption;Area;Biotechnology;career;Child;cohort;college;combat;Communities;Course Content;COVID-19 pandemic;Creativeness;design;Development;disadvantaged student;Disparity;Diverse Workforce;economic disparity;Ecosystem;Education;educational atmosphere;Educational Curriculum;Educational process of instructing;Educational workshop;empowerment;Engineering;engineering design;experience;falls;Fostering;girls;Goals;hackathon;High School Faculty;High School Student;improved;innovation;Instruction;Internships;Intervention;junior high school;K-12 Faculty;Knowledge;Learning;Medical;Medicine;Middle School Faculty;Middle School Student;Minority;Minority Groups;New York City;Next Generation Science Standards;open-ended problem;Outcome;Participant;Phase;Play;Process;programs;project-based learning;prototype;Public Health;Research;resilience;Role;Schools;Science;science education;Science, Technology, Engineering and Mathematics Education;Scientific Inquiry;Scientist;Self Efficacy;skills;STEM career;STEM field;student participation;Students;summer program;teacher;Teacher Professional Development;Technical Expertise;Testing;Thinking;Training;Translating;Underrepresented Minority;underrepresented minority student;Underrepresented Populations

PROJECT_TITLE: Hk Maker Lab 2.0: Inspiring Engineering Design Thinking in Grades 6 - 12 Students and Teacher

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: The project is intended to provide a new understanding of neuronal and glial development during late gestation and the early postnatal period. These are critical times in human neonatal brain development that are vulnerable to injuries, such as hypoxia, and can result in lifelong neuro-cognitive disabilities, including cerebral palsy and epilepsy.

PI_NAMEs: ALVAREZ-BUYLLA, ARTURO  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: ADGR1 gene;Amygdaloid structure;angiogenesis;Area;Autopsy;Blood Vessels;Brain;Brain Injuries;Brain Ischemia;brain tissue;Cell Communication;cell growth regulation;Cell Maturation;Cell Nucleus;Cells;Cerebral Palsy;Child;cognitive disability;Data;Development;Diagnosis;disability;Disease;Early treatment;Endothelial Cells;Epilepsy;Event;fetal;Financial Hardship;Foundations;frontal lobe;Funding;Gene Expression Profile;Genetic;glial cell development;Goals;Grant;Health;Heterogeneity;Histologic;Human;human migration;Hypoxia;In Situ Hybridization;Infant;Injury;insight;Interneurons;Invaded;Life;Ligands;Maps;Mediating;Microglia;migration;Morphology;Nature;Neonatal;neonatal brain;neonatal brain development;Neonatal Brain Injury;neonatal human;neonatal hypoxic-ischemic brain injury;nerve stem cell;Nervous System Trauma;neural circuit;Neurocognitive;neurodevelopment;neurogenesis;neurogenetics;neuron development;Neurons;neuropathology;Neurophysiology - biologic function;Newborn Infant;oligodendrocyte progenitor;Oligodendroglia;online resource;Pathway interactions;Perinatal;Play;postnatal;postnatal period;precursor cell;Pregnancy;Process;Production;programs;recruit;Regulation;Research;Research Personnel;Research Training;Resource Sharing;Resources;Rodent;Role;Route;scaffold;Science;Services;single nucleus RNA-sequencing;single-cell RNA sequencing;social;Specimen;stem cell expansion;stem cell migration;stem cell proliferation;synaptogenesis;System;training opportunity;transcriptomics;VEGFA gene;white matter

PROJECT_TITLE: Regulation of cellular pathways in human brain development


NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Pediatric

PROJECT_TERMS: adjudication;Administrator;Advisory Committees;Agreement;antenatal;Brain;Brain Injuries;Budgets;cell growth regulation;Cerebral Palsy;Collaborations;Communication;computerized data processing;cost effectiveness;Data;data sharing;Database Management Systems;Decision Making;Development;disability;Goals;Grant;Human;Human Resources;Infant;insight;Institution;Manuscripts;Neurocognitive;Pathway interactions;postnatal human;Preparation;Principal Investigator;Process;programs;Quality Control;Research Personnel;Research Training;Resources;Services;training opportunity

PROJECT_TITLE: CORE A: Administration


NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: HUANG, ERIC J (contact)

PROJECT_TERMS: Advisory Committees;Age;Autopsy;Board Certification;Brain;brain tissue;cell growth regulation;Cell Lineage;Cells;Childhood;Clinical;Collaborations;Consultations;cost effectiveness;Data;Data Analyses;Decision Making;Development;Disease;Doctor of Philosophy;Dorsal;Ensure;Epilepsy;experience;fetal;frontal lobe;Functional disorder;Funding;gliogenesis;Goals;Hippocampus;Histopathology;Human;human fetal brain;human tissue;hypoxic ischemic injury;Immunohistochemistry;In Situ Hybridization;interest;Interneurons;Maps;meetings;member;Microglia;migration;Mission;Molecular;molecular marker;Neonatal;nerve stem cell;Neuroanatomy;Neurobiology;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neuroglia;Neurology;Neurons;neuropathology;oligodendrocyte progenitor;Oligodendroglia;online resource;operation;Pathogenesis;Pathology;Pathway interactions;Perinatal;Physicians;postnatal;postnatal human;Pregnancy;prenatal;professor;Quality Control;Research;Research Personnel;Research Project Grants;Scientist;Services;single nucleus RNA-sequencing;single-cell RNA sequencing;Specimen;stem cells;Stream;success;System;Techniques;Technology;Temporal Lobe;Third Pregnancy Trimester;Tissue Banks;tissue preparation;tissue resource;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: CORE B- Neuropathology


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: KRIEGSTEIN, ARNOLD  (contact)

PROJECT_TERMS: Advisory Committees;Age;Algorithmic Analysis;Area;Bar Codes;Board Certification;Brain;brain cell;Brain region;brain tissue;Cancer Center;cell growth regulation;Cell Lineage;Cell Nucleus;cell type;Cells;Cerebral cortex;Chromosome Mapping;Clinical;cluster computing;Computer software;computerized data processing;computing resources;Cryoultramicrotomy;Custom;Data;Data Files;data sharing;design;Development;dimension reduction;Doctor of Philosophy;Ensure;Experimental Designs;Fluorescent in Situ Hybridization;Future;Gene Expression;Gene Expression Profile;gene network;Genetic Markers;Genomics;Goals;High Performance Computing;high standard;Histologic;Human;Image;In Situ;insight;interest;Interneurons;Joints;Laboratories;Maps;Measures;Methods;Microglia;migration;Modification;Molecular;molecular marker;Molecular Profiling;mRNA Precursor;mRNA sequencing;Mus;Nature;neocortical;Neonatal;neonatal brain development;neonatal human;neonatal hypoxic-ischemic brain injury;nerve stem cell;neural;neural circuit;Neuroglia;Neurologist;Neurology;Neurons;neuropathology;Neurosciences;novel;novel marker;Nuclear;Oligodendroglia;online resource;operation;Pathologic;Pathway interactions;Pediatrics;perinatal injury;Physicians;postnatal human;prenatal;Procedures;Process;professor;progenitor;Proteins;Protocols documentation;Publications;Pythons;Quality Control;Regional Anatomy;Research;Resolution;RNA;Sampling;Schedule;Scheme;Science;Scientist;Secure;Services;single cell mRNA sequencing;single cell sequencing;single nucleus RNA-sequencing;single-cell RNA sequencing;small molecule;Stream;Talents;Technology;Testing;Third Pregnancy Trimester;Tissue Preservation;Tissues;tool;Transcript;transcriptome sequencing;transcriptomics;Universities;Validation;Western Blotting;white matter injury;Work

PROJECT_TITLE: Core C Transcriptomics


NIH_SPENDING_CATS: Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PROJECT_TERMS: 3-Dimensional;Acute;Amygdaloid structure;Anatomy;Area;autism spectrum disorder;Autopsy;Behavior;Birth;Brain;cell growth;cell growth regulation;cell motility;Cells;Chain Migrations;cingulate gyrus;Cognition;Collection;Development;Disease;Dorsal;Epilepsy;Equilibrium;Etiology;Evolution;frontal lobe;Funding;Gene Expression Profile;Genetic;Goals;Grant;Growth;Histologic;Human;Human Characteristics;human stem cells;Image;improved;Individual;Infant;Infant Development;inhibitory neuron;interdisciplinary approach;Interneurons;Knowledge;Life;Medial;migration;migratory population;Molecular;Molecular Profiling;Neonatal;neonatal human;nerve stem cell;Neurodevelopmental Disorder;neurogenesis;neuron development;Neurons;neuropsychiatric disorder;novel;Output;Pathway interactions;Pattern;Perinatal;Population;postmitotic;postnatal;postnatal human;Pregnancy;progenitor;Property;Prosencephalon;reconstruction;Risk;Role;Route;Sampling;single-cell RNA sequencing;Site;Slice;Source;stem cell expansion;stem cell fate;stem cell proliferation;Stream;Structure;Testing;Third Pregnancy Trimester;transcription factor;transcriptomic profiling;transcriptomics;Work

PROJECT_TITLE: Project 1: The Origin and Diversity of Human GABAergic Interneurons


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Genetics;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke;Unintentional Childhood Injury

PI_NAMEs: FANCY, STEPHEN PHILIP JAMES (contact)

PROJECT_TERMS: angiogenesis;Animals;Arteries;arteriole;Biological Process;Blood Vessels;Brain;Brain Ischemia;Candidate Disease Gene;candidate identification;candidate validation;Cell Communication;cell fate specification;cell growth regulation;Cell Lineage;cell type;Cells;Cerebral Palsy;Cerebrovascular system;Chronic;Data;Development;Embryo;Endothelium;Functional disorder;gene conservation;Gene Expression;Gene Expression Profile;Genes;Genetic Markers;Human;Hypoxia;hypoxia neonatorum;In Situ;Infant;Injury;insight;Intellectual functioning disability;Interneurons;Ligands;Maps;Mediating;migration;Molecular;Morphology;Motor Neurons;Mus;myelination;Nature;Neonatal;neonatal brain;neonatal human;neonatal hypoxic-ischemic brain injury;neonatal injury;neonate;Nervous System Trauma;neural circuit;neurogenetics;Neurons;novel;novel marker;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Pathway interactions;Positioning Attribute;Premature Birth;Process;programs;Proliferating;Regulation;Reporting;resilience;Rodent;Role;scaffold;Science;single nucleus RNA-sequencing;Specific qualifier value;Spinal;Telencephalon;Testing;therapeutic development;Therapeutic Intervention;Time;transcriptomics;Up-Regulation;Vascular Endothelial Growth Factors;Vascularization;VEGFA gene;white matter

PROJECT_TITLE: Project 2: Mechanisms underlying oligodendrocyte precursor-mediated angiogenesis and interneuron vessel-associated migration in human neonatal brain


NIH_SPENDING_CATS: Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: PIAO, XIANHUA  (contact)

PROJECT_TERMS: Address;ADGR1 gene;Adhesions;age related;Anterior;Aorta;Apoptotic;autism spectrum disorder;Behavior;Birth;Brain;brain cell;Brain region;brain tissue;Cell Density;cell growth regulation;cell type;Cells;Cessation of life;conditional knockout;Cortical Dysplasia;Cues;Data;Development;Dorsal;Drug Design;Drug Targeting;Exhibits;Family member;Functional disorder;G-Protein-Coupled Receptors;Heterogeneity;Human;Interneurons;Knockout Mice;lateral ventricle;lateral ventricle body;Link;Macrophage;Medial;Microglia;migration;Mining;Molecular;Morphology;mouse model;Mus;nerve stem cell;neural circuit;Neurodevelopmental Disorder;Neuroglia;Neurons;neuropsychiatric disorder;novel;Pathway interactions;Population;postnatal;Process;progenitor;Proliferating;Property;Prosencephalon;Radial;Research;Role;Sampling;Schizophrenia;single nucleus RNA-sequencing;single-cell RNA sequencing;Somatosensory Cortex;Spatial Distribution;Structure;success;Testing;Third Pregnancy Trimester;timeline;TLR10 gene;Toll-like receptors;Transcript;transcriptome sequencing;transcriptomics;Transgenic Mice;translational potential;Work;Yolk Sac

PROJECT_TITLE: Project 3: Microglia heterogeneity and function in interneuron development


NIH_SPENDING_CATS: Physical Activity

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Cellular metabolism is crucial for maintaining energy and whole-body energy homeostasis. In this project, we propose to study a new signaling pathway that regulates oxidative metabolism in muscle. A deeper knowledge of lipid metabolism will provide new biomarkers and targets to improve energetic function in skeletal muscle and metabolic homeostasis.

PI_NAMEs: HAIGIS, MARCIA  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acetyl-CoA Carboxylase;Acute;addiction;Affect;arm;Biochemical;Biological Assay;Biological Markers;Catabolism;Cell Energetics;Cell Respiration;Cells;Cues;Dioxygenases;Elements;Energy Metabolism;Enzymes;Exercise;exercise capacity;Exercise Tolerance;Family;Fatty acid glycerol esters;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Goals;Health;Homeostasis;Human;hydroxyl group;Hydroxylation;Hypoxia Inducible Factor;improved;in vitro activity;in vivo;innovation;insight;Kinetics;Knockout Mice;Knowledge;Laboratories;Link;lipid metabolism;Lipids;Mammals;Mediating;member;Metabolic;metabolic fitness;Metabolism;Mitochondria;Modeling;Molecular;Muscle;Muscle Cells;Muscle Fibers;Muscle function;muscle metabolism;muscle physiology;new therapeutic target;novel;Nutrient;oxidation;Oxygen;Pathway interactions;personalized medicine;Phosphorylation;Physiological;Physiology;prevent;Procollagen-Proline Dioxygenase;Proline;Protein Family;Proteins;Recombinants;Repression;response;Rest;Role;Signal Pathway;Signal Transduction;Skeletal Muscle;Specificity;Stress;Tertiary Protein Structure;Testing;Therapeutic;therapeutic biomarker;Tissues

PROJECT_TITLE: Investigating the role of PHD3 in lipid homeostasis


ORG_CITY: RENO

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: The proposed MARC at the University of Nevada, Reno (MARC at UNR) will support diverse UNR College of Science trainees by providing an Enrichment Program that will prepare them for predoctoral graduate studies in biomedical or behavioral research. The proposed Enrichment Program includes two and a half years of mentored research, hands-on training in laboratory safety, weekly seminar/discussion classes providing peer support in the preparation of applications for summer research, for NSF Graduate Research Fellowship Program (GRFP), and for predoctoral graduate training. The MARC at UNR will also support the trainees with two years of formal career development mentoring using a Matrix Mentoring Model (Self, Senior, Scientific, Peer, and Staff mentoring).

PI_NAMEs: BURTNICK, MARY N;DUCKWORTH, MELANIE ;KIDD, THOMAS  (contact);YANG, YING

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Admission activity;African American;Award;Behavioral Research;Biology;Biomedical Research;Black race;career;CCL7 gene;Chemistry;cohort;college;Enrollment;ethnic diversity;experience;Exposure to;Extramural Activities;Faculty;Funding;graduate research fellowship program;graduate student;Hispanic;Immunology;Institution;Interest Group;Laboratories;Latinx;Mentors;Methods;Microbiology;Modeling;National Institute of Neurological Disorders and Stroke;Neurosciences;Nevada;Outcome;peer;peer coaching;peer support;Policies;Positioning Attribute;pre-doctoral;Preparation;programs;Psychology;Race;Recruitment Activity;Reproducibility;Research;Research Training;responsible research conduct;Safety;Science;Students;summer research;Teacher Professional Development;Training;Training Programs;Training Support;undergraduate student;Underrepresented Students;United States National Institutes of Health;Universities

PROJECT_TITLE: MARC at the University of Nevada, Reno

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE Pancreatic Cancer is far from being the most common cancer in the USA, yet it is projected to become the second deadliest (following lung cancer) by the year 2026 and no effective therapies are available to treat this cancer. This study will identify possible routes to restore the naturally protective activity of stromal cells that neighbor pancreatic tumors, which could prevent or delay the development and progression of Pancreatic Cancer. Further, results from the study will indicate whether the proposed “stroma normalization” could be informed by systemically in patients (i.e., in blood).

PI_NAMEs: CUKIERMAN, EDNA  (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: 3-Dimensional;Actin-Binding Protein;Actins;Animal Model;anti-cancer;antitumor effect;Archives;Biochemical;Biogenesis;Biological Markers;Blood;Bundling;cancer type;carcinogenesis;Cartoons;Cell secretion;Cells;Clinical;Clinical Trials;Data;Data Set;design;Desmoplastic;Detection;Development;ECM receptor;effective therapy;Endocytosis;Equilibrium;Exhibits;extracellular;Extracellular Matrix;extracellular vesicles;Feedback;Fibroblasts;Future;gain of function;genetic regulatory protein;Goals;Growth;Harvest;Homeostasis;Human;Immune system;immunoregulation;improved;In Vitro;in vivo;Inflammatory;inhibitor;Integrin alpha5beta1;Integrins;interstitial;Knock-out;Link;loss of function;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Metabolic;Metabolism;Methods;mimetics;minimally invasive;Modeling;Molecular;Molecular Conformation;Monitor;mouse model;Multivesicular Body;Mus;netrin-G1;novel;Nutritional;Outcome;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathologic;Patients;Peptide Receptor;Plasma;Polarization Microscopy;Population;postsynaptic;presynaptic;prevent;Process;Production;Proteins;proteomic signature;PTK2 gene;receptor;receptor binding;receptor function;Regulation;Reporting;response;restraint;Role;Route;sample archive;Sampling;Series;Signal Transduction;Stress;Stromal Cells;Structure;Supporting Cell;System;Testing;three dimensional cell culture;Tissues;transcriptome sequencing;Transforming Growth Factor beta;tumor;Tumor Immunity;Tumor Promotion;Work

PROJECT_TITLE: Pancreatic cancer-associated fibroblasts: function, detection, and regulation

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Social Determinants of Health

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: Narrative Underrepresented minorities are less likely to receive independent investigator awards from the National Institutes of Health. The result is a non-diversified workforce and less emphasis on diabetes-related health disparities research. The current study (called LAUNCHED) is designed to provide underrepresented minorities with a tailored training program to increase the chance of receiving diabetes, obesity, and/or nutrition funding.

PI_NAMEs: KATZMARZYK, PETER TODD;NEWTON, ROBERT LEE (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Academia;Address;Area;Award;Biomedical Research;career;career development;Center for Translational Science Activities;Centers of Research Excellence;Certification;Chronic Disease;Clinical Sciences;cohort;Collaborations;Data;design;Diabetes Mellitus;Digestive System Disorders;Disparity;Diverse Workforce;Education;Ensure;ethnic minority population;Ethnic Minority Women;experience;Faculty;Fellowship;Funding;Goals;Grant;Health;Health Disparities Research;health disparity;Health Sciences;higher education;Historically Black Colleges and Universities;Home;improved;Individual;Infrastructure;Institution;Instruction;interest;International;K-Series Research Career Programs;Kidney Diseases;Louisiana;member;Mentors;Mentorship;minority scientist;nutrition;Nutritional Study;Obesity;peer coaching;Population;Postdoctoral Fellow;primary outcome;Productivity;programs;Publications;recruit;Research;Research Personnel;role model;Scientist;secondary outcome;skills;success;Training;Training Programs;Translational Research;Underrepresented Minority;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: The Louisiana Center for Advancing Underrepresented Scientists Careers in Health, Nutrition, Obesity, and Disparities Research (LAUNCHED)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences

ORG_CITY: FORT COLLINS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative Experimental cognitive tests developed as part of the NIMH Research Domain Criteria (RDoC) initiative are liable to psychometric challenges that lead to inconsistent measurement precision, weakened effect size, and confounds in brain imaging research. This project evaluates a novel adaptive testing methodology designed to address these challenges. Products will include computerized adaptive measures of RDoC learning, control, and memory domains for use in experimental and translational studies, as well as a free and open-source programming (R) package, ‘catCog’, designed to implement the methodology.

PI_NAMEs: THOMAS, MICHAEL L (contact)

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Address;Back;Biological Markers;Brain;brain dysfunction;Brain imaging;Brain region;Clinical;Clinical Research;Cognitive;cognitive ability;cognitive control;cognitive function;cognitive neuroscience;cognitive process;cognitive task;cognitive testing;Communities;Companions;computerized;Control Groups;Data;design;Development;experimental study;Floor;improved;Individual;Intervention Studies;Learning;Measurement;Measures;Mediator;Memory;Mental Health;Mentored Patient-Oriented Research Career Development Award;Methodology;Methods;Modernization;National Institute of Mental Health;neural;Neurocognitive;neuroimaging;neuronal patterning;Neurons;neurophysiology;Neurosciences Research;novel;open source;Outcome;Outcome Measure;Participant;Patients;Performance;performance tests;Population;Process;Property;psychologic;Psychometrics;Psychoses;Pythons;Research;Research Domain Criteria;response;Rewards;Sampling;Schizophrenia;Short-Term Memory;Standardization;Stimulus;System;Task Performances;Technology;Testing;theories;Time;tool;Translational Research;translational study;Variant;Work

PROJECT_TITLE: An Adaptive Testing Platform for Optimizing RDoC Experimental Cognitive Measures

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


NIH_SPENDING_CATS: Cancer;Prevention;Urologic Diseases

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: Project Narrative The project seeks to validate a more reliable and accurate non-invasive assay to be used a) to diagnose bladder cancer and b) to early detect bladder cancer and which, over the long-term, could have a profound impact on the care of bladder cancer patients leading to improved care and reduced healthcare costs.

PI_NAMEs: ROSSER, CHARLES J (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Age;Algorithms;Biological Assay;Biological Markers;Bladder;Blood;cancer biomarkers;Cancer Detection;cancer diagnosis;Cancer Patient;Caring;Cessation of life;Clinical;clinical diagnosis;clinically relevant;cohort;Cost Analysis;Cystoscopy;Cytology;Data;Detection;detection assay;detection method;Diagnosis;Diagnostic;diagnostic algorithm;Diagnostic tests;Disease;Early Diagnosis;Ensure;Evaluation;Future;General Population;Goals;Guidelines;Health Care Costs;Hematuria;high risk population;Immunoassay;improved;in-vitro diagnostics;indexing;Longitudinal Studies;Malignant neoplasm of urinary bladder;Malignant Neoplasms;men;Methodology;Microscopic;Monitor;muscle invasive bladder cancer;Nested Case-Control Study;Newly Diagnosed;non-muscle invasive bladder cancer;noninvasive diagnosis;Patient Care;patient screening;Patients;prospective;Prospective Studies;Protein Fingerprints;Publishing;Randomized;Recommendation;Recording of previous events;Recurrent disease;Reporting;Research;Research Personnel;Retrospective cohort;Risk;Sampling;screening;Screening for cancer;Sensitivity and Specificity;Specificity;Survival Rate;Symptoms;Technology;Testing;Time;tobacco exposure;Training;tumor;tumorigenesis;Update;Urine;Validation

PROJECT_TITLE: APPLICATION OF A MULTIPLEXED IMMUNOASSAY FOR THE DETECTION OF BLADDER CANCER


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Project Narrative The goal of this program is to train the next generation of nurse scientists who will conduct research toward ending the HIV epidemic, while considering behavioral, socio-structural, and biomedical factors that cause disparities in HIV prevention and treatment. A group of 28 interdisciplinary faculty members with extensive HIV research experience will provide mentoring in research methods and HIV content for the four predoctoral and two postdoctoral scholars each year. This training program will advance knowledge to help end the HIV epidemic.

PI_NAMEs: DAWSON-ROSE, CAROL  (contact);SANTOS, GLENN-MILO

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TITLE: Next Generation Nurse Scientists Ending the HIV Epidemic


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Estrogen;Genetics;Human Genome;Lung;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Emphysema is a significant chronic disease with substantial morbidity and mortality and is resistant to most therapies because it is caused by irreversible anatomic destruction. Not much is known about the effects of sex differences on cellular abnormalities in emphysematous damage. Therefore, our proposal can provide critical information to assess the risk, identify the disease processes, and help develop strategies to mitigate and treat emphysema tailored with consideration for sex differences.

PI_NAMEs: MANICHAIKUL, ANI WANG;SHIM, YUN MICHAEL (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Air;airway obstruction;alveolar epithelium;Anatomy;Award;Biological;Biological Testing;Biology;Cell Lineage;Cells;chest computed tomography;Chronic;Chronic Disease;Chronic Obstructive Pulmonary Disease;Cigarette;cigarette smoke;cohort;Collaborations;Collection;Confusion;Data;density;Development;Diagnosis;Disease;Endothelial Cells;Endothelium;Epithelial Cells;Epithelium;Etiology;Evolution;exposure to cigarette smoke;Female;follow-up;former smoker;Future;Gene Cluster;Genes;Genetic Predisposition to Disease;Goals;gonad function;Gonadal Steroid Hormones;Gonadal structure;health care service utilization;High Prevalence;Human;immunomodulatory strategy;Knowledge;Lung;Lung Diseases;lung injury;Lung Transplantation;Lung Volume Reductions;Macrophage;male;Mediator;Modeling;monocyte;Morbidity - disease rate;mortality;Motivation;mouse model;Multi-Ethnic Study of Atherosclerosis;Mus;Myeloid Cells;non-smoker;novel diagnostics;novel therapeutics;Ovariectomy;Ovary;Participant;Pathogenesis;Pathology;Pathway Analysis;Pattern;Play;Predisposition;Process;Pulmonary Emphysema;Pulmonary Pathology;Reporting;Resistance;Risk;Risk Assessment;Risk Behaviors;Role;Severities;sex;Sex Differences;sexual dimorphism;single-cell RNA sequencing;Smoke;Smoker;Structure;Structure of parenchyma of lung;Testing;tissue injury;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Visit;Work

PROJECT_TITLE: Sexual dimorphism in susceptibility to emphysematous tissue injury

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]