NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Pregnancy;Primary Health Care;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Ten to 20% of women in the perinatal period (pregnancy and up to one year postpartum) suffer from depression, yet many, especially low income racial ethnic minority women, never receive mental health treatment. Although parenting is a crucial aspect of the perinatal period, and parenting difficulties contribute to negative maternal and child outcomes, primary care-based treatments for perinatal depression do not include attention to parenting. We will test a comprehensive primary care based perinatal depression treatment which includes attention to parenting and has the potential to improve maternal and child outcomes.

PI_NAMEs: BHAT, AMRITHA SUBRAY (contact)

PROGRAM_OFFICER_NAME: CHU, SERENA PO-LAN

PROJECT_TERMS: Address;Affect;Aftercare;antenatal;antepartum depression;anti-depressive agents;Attention;Belief;Caring;Child;Child Rearing;collaborative care;Consultations;coping;Data;Depressed mood;depressive symptoms;Disability scale;Discipline of obstetrics;dyadic interaction;Education;effectiveness study;effectiveness-implementation RCT;Equipment and supply inventories;Ethnic Minority Women;evidence base;Evidence based intervention;Evidence based treatment;experience;feasibility testing;Feedback;Funding;Future;Health;help-seeking behavior;human centered design;Hybrids;Impairment;Improve Access;improved;indexing;Infant;Interview;Low income;maternal depression;maternal outcome;Measures;Mediating;Mediator;medical specialties;Mental Depression;Mental Health;Mental Health Services;Methodology;Methods;Moods;Mother-Child Relations;motherhood;Mothers;multidisciplinary;National Institute of Mental Health;Outcome;parenting intervention;Parents;Patients;Perinatal;perinatal period;peripartum depression;Pilot Projects;pilot test;Postpartum Depression;Postpartum Period;Pregnancy;prenatal;Prenatal care;prevent;Primary Care;primary care setting;Procedures;programs;Protocols documentation;Provider;Race;racial minority women;Randomized;recruit;Reporting;Research;response;Risk;Role;Sampling;Self Efficacy;Severities;social stigma;Symptoms;Techniques;Testing;uptake;user centered design;Variant;verbal;Woman;Work

PROJECT_TITLE: A Dyadic Approach to Perinatal Depression Treatment in Primary Care


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Burden of Illness;Clinical Research;Diabetes;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Obesity;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: WINSTON-SALEM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Narrative The over-arching goal of this proposal is to understand the pathophysiology underlying basal and dynamic measures of insulin resistance and insulin secretion with translation of their impact to clinical disease, i.e. type 2 diabetes.

PI_NAMEs: ALLRED, NICHOLETTE D. (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Affect;African American;American;Architecture;Asian;Beta Cell;Biological;Biological Process;blood glucose regulation;Cardiovascular Diseases;case control;Case/Control Studies;Cellular biology;Clinical;Clinical Management;clinical phenotype;clinically relevant;cohort;Collaborations;Communities;Complement;Complex;Data;Data Set;Defect;design;Detection;Diabetes Mellitus;diabetes risk;Diagnosis;Disease;Early Diagnosis;Economic Burden;Effectiveness;Epidemiology;European;Evaluation;Functional disorder;Funding;Genes;Genetic;Genetic Determinism;Genetic study;Genetic Variation;genome wide association study;genome-wide;Glucose;Goals;Heritability;high risk;Hispanic Populations;Human;improved;in silico;indexing;Individual;insight;Insulin Resistance;insulin secretion;insulin sensitivity;Intervention;Letters;Linkage Disequilibrium;Maps;Measures;Medical Care Costs;Meta-Analysis;metabolomics;Methodology;Mexican;Mexican Americans;Minority Groups;Modality;Modeling;molecular phenotype;multi-ethnic;multiple omics;Nature;next generation sequencing;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Pattern;Phenotype;Physiological;Population;Prediabetes syndrome;Prevention;Productivity;Public Health;rare variant;Recording of previous events;Report (document);Research;resistance gene;Resources;Risk;risk prediction;Sample Size;Sampling;South Asian;success;Testing;trait;Translating;Translations;Variant

PROJECT_TITLE: Genetic and Epidemiological Predictors of Glucose Homeostasis Measures

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Climate-Related Exposures and Conditions;Social Determinants of Health

ORG_CITY: RALEIGH

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: PROJECT NARRATIVE Causal inference theory and methods are indispensable to biostatistics, but due to complications such as spatial correlation and spillover effects, methods applicable to spatial data are limited. In this project, we develop new causal methods to allow researchers to extract knowledge from observational spatial data. The methods are developed in the context of two large epidemiological studies of the effects of wildland ﬁre smoke and preventative measures on air pollution exposure and respiratory health outcomes.

PI_NAMEs: REICH, BRIAN J.;YANG, SHU  (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Address;Air Pollution;ambient air pollution;Biometry;Cardiovascular system;causal model;Characteristics;citizen science;climate change;Complex;Computer software;Computing Methodologies;cost;Data;Data Set;design;Discipline;distributed data;Economics;effectiveness evaluation;Environmental Epidemiology;Environmental Health;Epidemiology;epidemiology study;Event;experience;experimental study;Exposure to;Fire - disasters;Formulation;Future;Goals;Health;Health behavior and outcomes;health data;Health Sciences;Heterogeneity;Hospitalization;Image;Individual;Joints;Knowledge;large datasets;Literature;Location;Maps;Measurement;Medicare;Methods;Modeling;Nature;Neighborhoods;novel;Outcome;Pattern;Prevalence;Preventive measure;Public Health;Randomized;Recommendation;Research;Research Personnel;Resolution;respiratory;respiratory health;response;Risk;Selection for Treatments;simulation;smartphone application;Smoke;Social Sciences;spatiotemporal;statistics;Structural Models;Structure;Surveys;Theoretical Studies;theories;Time;tool;Translating;treatment effect;treatment response;Uncertainty;United States;United States Environmental Protection Agency;Wildfire;Work

PROJECT_TITLE: Spatial Causal Inference for Wildland Fire Smoke Effects on Air Pollution and Health

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Lung;Patient Safety;Precision Medicine

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Asthma affects an estimated 300 million individuals worldwide, accounts for an estimated $81.9 billion in direct health care costs in the United States annually, with a disproportionate amount directed at more severe asthma. Novel asthma biologic therapies are expensive and there remain a significant proportion of non- responders to those therapies. Through a clinical cohort characterizing within-person genomic responses, this proposal has the potential to personalize asthma therapeutic response to these biologic agents and provide detailed understanding about the mechanisms underlying asthma that may one day be relevant to the further treatment or prevention of this disease.

PI_NAMEs: BLEECKER, EUGENE ROLAND;CHUPP, GEOFFREY L;TANTISIRA, KELAN G (contact);WEISS, SCOTT T

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Address;Adrenal Cortex Hormones;Affect;Asthma;asthmatic;Biological;Biological Assay;Biological Markers;Biological Products;Biological Response Modifier Therapy;Biology;Blood;Blood specimen;Cells;Clinical;clinical application;clinical biomarkers;clinical phenotype;clinical subtypes;clinically relevant;cohort;Computing Methodologies;cost effective;Data;Development;Diagnosis;Direct Costs;Disease;disease heterogeneity;disorder prevention;economic cost;eosinophil;evidence base;FDA approved;Gene Expression Profile;Genomic approach;genomic data;genomic signature;Genomics;Goals;Health Care Costs;Human;IL4 gene;IL5 gene;Immunomodulators;immunoregulation;Individual;individual response;Inflammatory;insight;Interleukin-13;Intervention;knock-down;Link;Medicine;Modeling;Molecular;Monitor;non-smoking;novel;novel therapeutics;Outcome;Pathway interactions;Persons;Pharmaceutical Preparations;Pharmacogenomics;pharmacologic;Phenotype;precision medicine;predicting response;Prediction of Response to Therapy;predictive marker;primary outcome;prognostic;Prognostic Marker;prognostic model;programs;randomized, clinical trials;Research;responders and non-responders;response;response biomarker;Sensitivity and Specificity;Series;Severities;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;Sputum;Statistical Models;Subgroup;Symptoms;System;Systems Biology;Therapeutic;therapeutic biomarker;Therapeutic Intervention;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Translations;treatment response;United States

PROJECT_TITLE: Leveraging Pharmacogenomics in Asthma for Predication, Mechanism and Endotyping

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: NORTH LITTLE ROCK

ORG_NAME: CENTRAL ARKANSAS VETERANS HLTHCARE SYS

ORG_STATE: AR

PHR: Project Narrative  The proposed aims address a critically important gap in Veterans’ health care - specifically, the need to identify effective strategies for linking Veterans in VHA PC who screen positive for hazardous drinking and PTSD and/or depression to alcohol care. Our VHA partners in the Office of Primary Care and Office of Mental Health and Suicide Prevention are highly interested in implementing SLAC nationally should it be found to be effective in a subsequent, fully powered RCT. The aims of this proposal support VA HSR&D priorities (Access to Care, Mental Health, and Primary Care) by adapting and pilot testing a novel intervention to help facilitate Veterans’ linkage to alcohol care. Increasing the use of care among this high need Veteran population is likely to lead to significant reductions in acute health care costs and improved outcomes.

PI_NAMEs: CUCCIARE, MICHAEL ANTHONY (contact);TIMKO, CHRISTINE D

PROJECT_TERMS: Academy;Acute;Address;adverse outcome;Age;Alcohol abuse;Alcohol consumption;alcohol screening;alcohol use disorder;Alcohols;Area;barrier to care;Behavioral;care seeking;Caring;Chronic;Clinical;clinical care;Clinical effectiveness;comorbidity;cost outcomes;Counseling;Decision Making;design;diagnostic criteria;Disease;drinking;Educational process of instructing;Effectiveness;eHealth;Enrollment;evidence base;Evidence based intervention;follow-up;hazardous drinking;Health Care Costs;Health Personnel;Health Services Accessibility;Healthcare;High Prevalence;high risk;Hybrids;Improve Access;improved;improved outcome;information gathering;innovation;interest;Intervention;Interview;Knowledge;Letters;Link;Measures;Medical;medical specialties;medication-assisted treatment;meetings;member;Mental Depression;Mental Health;Mental Health Services;Methodology;military veteran;Monitor;Motivation;novel;novel strategies;operation;Outcome;Patients;pilot test;pilot trial;Population;Post-Traumatic Stress Disorders;Primary Care;primary care provider;primary care setting;Provider;Psychologist;Randomized, Controlled Trials;Recommendation;Reporting;Risk;Role;satisfaction;screening;Services;Site;skills;Social Workers;substance use;Substance Use Disorder;Suicide prevention;telephone delivery;Testing;Uncertainty;Veterans

PROJECT_TITLE: Multi-site Pilot Trial of Strengths-based Linkage to Alcohol Care (SLAC) for Hazardous Drinkers in Primary Care

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative  Attention Deficit Hyperactivity Disorder (ADHD) is a common, chronic, and impairing condition of childhood whose diagnosis and treatment remain controversial. The current project seeks to clarify the cognitive, emotional, and neurobiological mechanisms at play in the disorder. It is hoped the results will help to improve diagnostic practices and inform development of new treatments.

PI_NAMEs: KARALUNAS, SARAH LYN (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: 10 year old;Address;Affective;Attention;Attention deficit hyperactivity disorder;Behavior;Behavioral;biobehavior;Biological;case control;Central Nervous System;Child;Childhood;Chronic;Clinical;clinical translation;Cluster Analysis;Cognition;Cognitive;cognitive control;Complex;Computer Models;Consensus;cost;design;Development;Diagnosis;Diagnostic;Dimensions;Disease;disease classification;Dissociation;Ecological momentary assessment;Electroencephalography;emotion dysregulation;Emotional;emotional experience;emotional stimulus;Emotions;Event-Related Potentials;Goals;Grouping;Heterogeneity;Impairment;improved;in vivo;Individual Differences;Intervention;Joints;Laboratories;Measurement;Measures;Mediating;Methods;Modeling;Moods;National Institute of Mental Health;negative mood;Negative Valence;Nervous System Physiology;neurobiological mechanism;Nonpharmacologic Therapy;novel;Outcome;Peripheral Nervous System;Pharmacological Treatment;Phenotype;Play;Positive Valence;Psychopathology;Research Domain Criteria;Sampling;Stimulus;stimulus processing;Temperament;Testing;Time;trait;Typology;Validation;Variant;visual tracking;Work

PROJECT_TITLE: Biobehavioral validation of the ADHD emotion dysregulation phenotype

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Racial and Ethnic Minority Health Research

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: The way that blood pressure is being measured in clinical practice may lead to the misdiagnosis of hypertension. This study will examine among African Americans how well a new approach for measuring blood pressure in the clinic identifies hypertension status outside the clinic.

PI_NAMEs: ABDALLA, MARWAH  (contact)

PROGRAM_OFFICER_NAME: PUGGAL, MONA A

PROJECT_TERMS: Address;Adult;Affect;African American;African American population;Ambulatory Blood Pressure Monitoring;Ancillary Study;Attention;awake;Blood Pressure;blood pressure reduction;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Chronic Kidney Failure;Clinic;clinical practice;cohort;Communities;cost;Data;design;Detection;Devices;Diagnosis;Enrollment;Equipoise;Event;Future;Goals;Guidelines;High Prevalence;Hour;Hypertension;hypertension control;Individual;Individual Differences;Jackson Heart Study;Left Ventricular Hypertrophy;masked hypertension;Measurement;Measures;Methodology;Methods;monitoring device;novel strategies;Organ;patient tolerability;Population;Prevalence;Provider;Randomized;randomized, controlled study;Recommendation;Risk;Sampling;Specialist;Test Result;white coat hypertension

PROJECT_TITLE: Automated clinic blood pressure assessment and detection of white coat and masked hypertension study in African Americans

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: LAS CRUCES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

ORG_STATE: NM

PHR: Project Narrative Over 6 million Americans suffer from heart failure, and their hospitalizations cost $16 billion annually. Although intracardiac pressure monitoring implants have proven effective in reducing hospitalization risks, they still present complications due to the large form factor required for devices with radiofrequency communications. This project investigates ultrasound signals for wireless communications and develops next-generation implants that are smaller, minimally invasive, and safer.

PI_NAMEs: ALAIE, SEYEDHAMIDREZA  (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: Acoustics;Affect;American;Atrial Heart Septal Defects;Attenuated;attenuation;Chronic;Communication;dacron;design;Detection;Devices;Distress;Echocardiography;Elasticity;Electromagnetic Energy;Electromagnetics;Electronics;Engineering;Equipment Malfunction;Event;Evolution;fabrication;Film;flexibility;Frequencies;Future;Gases;Geometry;Healthcare Systems;Heart Atrium;Heart failure;heart motion;hemocompatibility;hemodynamics;high risk;Hospital Costs;Hospitalization;Human body;Hydrocephalus;Imaging Device;Implant;implantable device;In Vitro;in vivo;in vivo evaluation;innovation;intracardiac pressure;Intracranial Pressure;Left;Left atrial structure;Life;Liquid substance;Measurement;Medical;medical attention;Medical Imaging;meter;Microbubbles;millimeter;Miniaturization;miniaturize;minimally invasive;Monitor;next generation;nitinol;novel;Organ;Patients;Periodicals;Physicians;Physics;Physiologic Monitoring;Physiological;polydimethylsiloxane;Polymers;pressure;prevent;Procedures;Protocols documentation;Pulmonary artery structure;radio frequency;remote monitoring;Research;Resolution;Right ventricular structure;Risk;Risk Reduction;Route;Safety;Semiconductors;sensor;Side;Signal Transduction;simulation;System;Technology;Tecoflex;temporal measurement;Testing;Textiles;Thick;Thrombosis;Time;Tissues;tool;transmission process;Travel;Ultrasonic Transducer;Ultrasonic wave;Ultrasonics;ultrasound;Ventricular;Water;water vapor;wireless communication;wireless fidelity;wireless implant;wireless sensor;Wireless Technology

PROJECT_TITLE: Film-like Acoustic Microresonators for Wireless Monitoring of Intracardiac Pressure using Ultrasound

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Orthopaedic bone infection is life-threatening and current treatments are only sparingly successful. To overcome the barriers associated with eradicating infection from bone, we will develop cold plasma and plasma-activated liquid (PAL) treatments that directly disrupt biofilms and eradicate bacteria from bone and surrounding tissues, while stimulating an immune response. This novel approach will alleviate complications associated with antiseptic toxicity, antibiotic resistance and overuse, and permit robust tissue healing.

PI_NAMEs: BOURKE, PAULA ;FREEMAN, THERESA A (contact);GILMORE, BRENDAN ;HICKOK, NOREEN J

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Animal Model;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotic Therapy;Antibody titer measurement;antimicrobial;Area;Bacteria;Bacterial Antigens;Biocide;bone;Cells;Cellular biology;Chemistry;chemokine;Clinical;Clinical Medicine;Clinical Protocols;clinically relevant;combat;comparison intervention;Coupled;cytokine;Data;Dendritic cell activation;Detection;drug resistant pathogen;Effectiveness of Interventions;Engineering;Eukaryotic Cell;Fracture;Fracture Fixation;healing;Immune;immune activation;Immune response;Immune system;Immunologic Stimulation;Immunologic Surveillance;Impairment;Implant;Infection;Inflammatory;instrumentation;International;Ireland;Knee;Leukocytes;Life;Liquid substance;Local Anti-Infective Agents;Macrophage;Malignant Neoplasms;materials science;Melanoma;methicillin resistant Staphylococcus aureus;Microbial Biofilms;microbicide;Microbiology;Modality;Modeling;Nature;Northern Ireland;novel;novel strategies;Open Fractures;Organism;Orthopedics;Osteomyelitis;Osteotomy;Penetration;Perioperative;Phagocytosis;Plasma;Procedures;Production;programs;Property;Rattus;recruit;Reproducibility;Research;Research Personnel;response;Risk;Sheep;Site;Spinal;standard of care;Surgical Wound Infection;Technology;Testing;Tissues;Toxic effect;Treatment Protocols

PROJECT_TITLE: Plasma-based therapies for bone infection: A tripartite USA/Northern Ireland/Republic of Ireland consortium


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Poor sleep is a nearly universal experience for Veterans with post-traumatic stress disorder (PTSD), and the current first-line psychotherapy for insomnia disorder - cognitive-behavioral therapy for insomnia (CBT-I) - is less beneficial for individuals with comorbid PTSD. This study will evaluate a newly-developed psychotherapy for insomnia disorder in the context of PTSD called “Acceptance and the Behavioral Changes to treat Insomnia (ABC-I), which incorporates the core behavioral components of CBT-I with the theoretical framework and techniques from Acceptance and Commitment Therapy (ACT). The results of this study will improve knowledge about the best non-medication treatments for insomnia disorder for Veterans with PTSD.

PI_NAMEs: MARTIN, JENNIFER L (contact)

PROJECT_TERMS: Address;Adopted;Adoption;Aftercare;Anxiety;Area;Attenuated;avoidance behavior;Behavior;Behavioral;Clinical;clinical care;Cognitive;Cognitive Therapy;Combined Modality Therapy;Comorbid Insomnia;comorbidity;Data;design;diaries;effective therapy;effectiveness evaluation;evidence base;Exclusion Criteria;Exercise;experience;Feeling suicidal;flexibility;follow-up;Health;improved;improvement on sleep;Individual;innovation;interest;Intervention;Knowledge;Measures;Medicine;Mental Depression;Mental Health;Methodology;mindfulness;Neurobehavioral Manifestations;novel;Outcome;Outcome Measure;Outcome Study;Pathway interactions;Patients;poor sleep;Population;Post-Traumatic Stress Disorders;Process;Process Measure;programs;Provider;psychologic;Psychotherapy;Quality of life;Randomized;randomized trial;Recommendation;reducing suicide;Relaxation;response;Services;Sleep;Sleep Disorders;Sleep disturbances;sleep health;sleep quality;Sleeplessness;sound;Specific qualifier value;standard care;Stimulus;Symptoms;Techniques;Testing;Therapeutic Intervention;therapy design;Time;Training;Training Programs;treatment response;trial design;Veterans;women's treatment;Work

PROJECT_TITLE: A Novel Acceptance-based Treatment for Insomnia in Veterans with Post-Traumatic Stress Disorder


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: BALTIMORE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: RESEARCH NARRATIVE Electrical stimulation of low-threshold Aβ-nerve fibers is a clinical strategy for treating pain that is not relieved by medications, but the stimulation is not fully effective and its benefits are short-lived. Researchers have been unable to further improve the therapy because the mechanisms underlying pain inhibition by electrical stimulation are unclear. The central goal of this study is to uncover spinal neuronal and non-neuronal mechanisms of pain inhibition by Aβ-fiber activation, and to identify what biological processes could be targeted with drugs to enhance pain inhibition and avoid side effects.

PI_NAMEs: GUAN, YUN  (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Adenosine;Adjuvant;Adverse effects;Affect;Agonist;Amyloid beta-Protein;Animal Model;Anti-Inflammatory Agents;Astrocytes;Attenuated;Behavior;Biological;Biological Process;C Fiber;Chemosensitization;chronic pain management;Clinical;Clinical Trials;cost;dorsal column;dorsal horn;Dose;Dose Limiting;Drug Targeting;Electric Stimulation;Electrophysiology (science);Etiology;excitatory neuron;Fiber;Floods;Frequencies;Future;gamma-Aminobutyric Acid;Genetic;Goals;Heterogeneity;Homeostasis;Human;human study;Image;improved;in vivo;Induced Neurons;Inflammation Mediators;Inflammatory;Interneurons;Link;Microglia;Nerve Fibers;nerve injury;neurochemistry;Neuroglia;Neurons;Nociception;novel;Opioid;optogenetics;Pain;pain inhibition;painful neuropathy;patch clamp;Pathogenesis;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Physiological;Play;Posterior Horn Cells;Process;Rattus;receptor;Receptor Activation;Refractory;Research Personnel;reuptake;Role;side effect;Signal Transduction;Slice;Specificity;Spinal;Spinal Cord;System;Technology;Testing;tool;translational study;transmission process

PROJECT_TITLE: Mechanistic Study of Pain Inhibition by Activation of Non-nociceptive Afferent Fibers

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This research study is designed to improve social communication, cognition and language outcomes for toddlers responding slowly to best informed, evidence based intervention in real world community settings through local stakeholders’ implementation of an adaptive sequence of social communication intervention strategies. If found efficacious, the adaptive intervention design will capitalize on the heterogeneity and evolving status of children with ASD and their teachers by providing the best intervention for children who need it (leading to individualized sequences of intervention), only when it is needed (potentially reducing burden on intervention programs and children).

PI_NAMEs: KASARI, CONNIE L. (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: 3 year old;adaptive intervention;Address;Adoption;autism spectrum disorder;autistic children;Child;Child Development;Cognition;Cognitive;Communities;community setting;comorbidity;design;Development;Early Intervention;Education;Educational process of instructing;Effectiveness;effectiveness testing;efficacious intervention;evidence base;Evidence based intervention;Experimental Designs;Funding;Goals;Health Personnel;Heterogeneity;Hybrids;Impairment;implementation efforts;implementation evaluation;implementation fidelity;implementation intervention;implementation/effectiveness;improved;improved outcome;Individual;Infant;Intellectual impairment;Intervention;intervention program;joint attention;Joints;Language;Language Delays;language outcome;Leadership;Learning;Manuals;Measurement;Measures;member;New York;novel;Outcome;peer;Phase;Play;primary outcome;process evaluation;programs;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Regulation;Research Design;research study;response;Role;secondary outcome;Sequential Multiple Assignment Randomized Trial;service intervention;skills;social;social communication;Socialization;Structure;Target Populations;teacher;teaching assistant;Testing;therapy design;Time;Toddler;Training;treatment response;trial design;Work

PROJECT_TITLE: Community-based Adaptive autism Intervention for Toddlers


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE The proposed project will help prevent further deterioration of social behaviors and promote the well-being of minority at-risk girls and their peers, and school staff in urban communities by demonstrating the effectiveness of Friend to Friend with Coaching, a relational aggression intervention designed specifically for this target population and led by school staff with training and coaching by the research team. The project will also explore mediating and moderating factors associated with program effectiveness and factors associated with staff adoption of the program after active coaching is finished. Results will demonstrate Friend to Friend with Coaching provides staff with skills and confidence to independently conduct effective social-emotional programming and will also inform the field of necessary factors that facilitate sustainable school-led programming for relationally aggressive youth, which addresses a significant public health issue and aligns directly with NICHD's mission to improve the health and wellness of youth.

PI_NAMEs: LEFF, STEPHEN S (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Address;Adolescence;Adopted;Adoption;aggression prevention;Aggressive behavior;Behavior;Clinical Trials;cohort;design;Deterioration;educational atmosphere;Effectiveness;effectiveness evaluation;emerging adult;emotion regulation;Emotional;fifth grade;fourth grade;Friends;Funding;Future;Future Teacher;Geographic Locations;girls;Goals;group intervention;Health;high risk;implementation fidelity;improved;Intervention;Knowledge;Leadership;low socioeconomic status;Mediating;Mediator;Minority;minority children;Mission;National Institute of Child Health and Human Development;peer;Personal Satisfaction;Populations at Risk;prevent;Prevention;Prevention program;primary outcome;Problem Solving;Process;Professional counselor;Program Effectiveness;Program Sustainability;programs;Public Health;Randomized;Randomized, Controlled Trials;Research;Research Personnel;Research Project Grants;Resources;response;Risk;Running;Safety;scale up;Schools;Self Efficacy;skills;social;Social Behavior;social exclusion;Social Problems;Social status;Students;success;Target Populations;teacher;therapy design;Time;Training;Translating;Urban Community;urban minority;urban school;Work;Youth

PROJECT_TITLE: The Friend to Friend Program: Effectiveness when Conducted by School Staff

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: BERKELEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative The proposed research is relevant to public health because it will inform population health and clinical care approaches to address maternal and infant health disparities by race/ethnicity and foreign-born status, and motivate violence prevention programs that both reduce immediate injuries and deaths, and ultimately improve maternal and infant health and reduce health disparities in the US. The project is responsive to NIH’s mission that includes the goal “to foster fundamental creative discoveries, innovative research strategies, and their applications as a basis for ultimately protecting and improving health”, because the innovative and rigorous approach will enable scientific understanding to meaningfully advance and thereby inform and motivate intervention. In particular, this project is in close alignment with NICHD’s priorities for research that include “advance knowledge of pregnancy, fetal development, and birth for developing strategies that prevent maternal, infant, and childhood mortality and morbidity”, and directly responsive to NICHD Pregnancy and Perinatology Branch research priorities in the areas of Perinatal Health Disparities, that includes a focus on the community level social determinants, and Preterm Birth and Its Consequences.

PI_NAMEs: AHERN, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Acute;Address;adverse maternal outcomes;Affect;African American population;African American Women;Area;Behavioral;Biological;Birth;Buffers;California;Cessation of life;Childhood;clinical care;Communities;community violence;Creativeness;Data;Databases;design;Disparity;disparity reduction;Economics;ethnic disparity;ethnic minority population;Ethnic Origin;Ethnic Population;experience;Exposure to;Fetal Death;Fetal Development;Fetal Growth Retardation;Fostering;Gestational Diabetes;Goals;Health;health determinants;health disparity;Healthcare;improved;Infant;Infant Health;infant outcome;Infection;Injury;innovation;Intervention;Knowledge;Latina Population;Maternal Health;Mediating;Mediator;Mental Health;Methods;Mission;Morbidity - disease rate;mortality;Mothers;National Institute of Child Health and Human Development;Neonatal Mortality;novel;Outcome;perinatal health;Perinatology;Population;population health;postneonatal mortality;Pre-Eclampsia;Pregnancy;Premature Birth;prevent;Prevention program;psychologic;Public Health;Quasi-experiment;Race;racial disparity;racial health disparity;racial minority population;racial population;Reduce health disparities;Research;Research Priority;Resources;response;Risk;Role;Sampling;Shapes;social determinants;Social support;substance use;Surveys;Testing;United States;United States National Institutes of Health;Variant;Violence;violence prevention;White Women;Work

PROJECT_TITLE: Community violence and disparities in maternal and infant health: effects and mechanisms

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative OurChild is a digital platform that links an in-home smartphone app (available in Chinese and English) with the electronic health record to improve access to mental health knowledge and care for Chinese American young children and their families. Parents collect information about their child’s mental health and receive real-time actionable insights and resources. Clinical information is automatically shared with the child’s doctor to improve referral to mental health services, parent-provider engagement, and linkage with clinical and community services.

PI_NAMEs: KWON, SIMONA  (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: 6 year old;Address;Adolescent Psychiatry;Adoption;Adult;Age;Caring;Child;Child Mental Health;Child Psychiatry;Child Rearing;Childhood;Chinese;Chinese American;Chinese population;Clinic;Clinical;Clinical Services;cohort;Cohort Studies;Collaborations;Communities;Community Services;Consolidated Framework for Implementation Research;Consultations;Data;Data Reporting;design;design,build,test;Development;developmental disease;digital;digital health;Digital Libraries;digital platform;digital solutions;Disparity;early childhood;Early identification;Effectiveness;Electronic Health Record;Evaluation;evidence base;Family;Family health status;Focus Groups;Goals;Health;health care availability;Health Disparities Research;health disparity;health disparity populations;health knowledge;health literacy;Health Resources;Health Services Accessibility;Health system;Healthcare;high school degree;Home;human centered design;Immigrant;Immigrant community;Immigrant family;Impairment;Improve Access;improved;Incubators;Individual;innovation;insight;iterative design;Knowledge;Language;Libraries;Life;Limited English Proficiency;Link;Mental disorders;Mental Health;Mental Health Services;Metadata;Methodology;Methods;mHealth;minority health disparity;National Institute on Minority Health and Health Disparities;New York City;Outcome;Parents;patient health information;patient portal;Performance;Population;post implementation;Poverty;Prevalence;prototype;Provider;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reduce health disparities;Research;Resources;response;safety net;Self Efficacy;smartphone application;social stigma;Testing;Time;tool;Translating;usability

PROJECT_TITLE: OurChild: A Health IT Solution to Reduce Minority Health Disparities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-K(56)R]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BOZEMAN

ORG_DEPT: CHEMISTRY

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: PROJECT NARRATIVE Iron-deficiency and associated anemias are widespread nutritional disorders worldwide, in spite of sufficient iron in many diets. Undigested heme-iron from red meat is likewise associated with the development of colon cancer. The proposed work will show how anaerobic bacteria in the digestive tract metabolize heme, and how this ultimately influences host uptake of iron. This will influence the development of probiotic strategies for enhancing absorption of nutritional iron and offsetting disease.

PI_NAMEs: DUBOIS, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: absorption;Aerobic;Anaerobic Bacteria;Anemia;Animals;Bacteria;Bacteroides thetaiotaomicron;Biochemistry;catalyst;Cells;Chemicals;Clostridium;Coculture Techniques;Colitis;Collaborations;Colon;Colon Carcinoma;commensal bacteria;Communities;Culture Media;Development;Diet;Dietary Iron;Disease;Ecosystem;Enteral;Escherichia coli;flasks;Gastrointestinal tract structure;gene product;Generations;Genes;Gnotobiotic;Goals;gut microbes;Heme;Heme Iron;host microbiome;Human;Infection;Inflammation;Infrastructure;interest;Iron;iron deficiency;iron metabolism;Isotope Labeling;Knock-out;Knowledge;Lactobacillus casei rhamnosus;Meat;Mediating;member;Metabolic Pathway;Metabolism;microbial;microbiome;Mus;Nutrition Disorders;Nutritional;Play;Population;Probiotics;Process;Proteome;remediation;Respiration;Role;Stable Isotope Labeling;Time;uptake;Walking;Work

PROJECT_TITLE: Understanding how heme and iron are metabolized by anaerobic commensal bacteria and host-microbiome communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative In this project we take advantage of the UNEEG SubQ device for chronic subscalp EEG recording with distributed local and cloud analytics, telemetric data streaming, and patient-physician interface. This innovative distributed monitoring system will be used to detect electrophysiological and behavioral biomarkers impending seizures to guide self-administration of fast-acting medications. Our goal is to develop within the existing seizure management system a novel, targeted treatment method for epilepsy.

PI_NAMEs: BRINKMANN, BENJAMIN H (contact);WORRELL, GREGORY A

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

PROJECT_TERMS: Affect;algorithm development;algorithm training;Automobile Driving;Behavioral;Benzodiazepines;Biological Markers;Chronic;Clinical;cohort;convolutional neural network;Data;data acquisition;data streams;Detection;Devices;Disease;Dose;Electrodes;Electroencephalography;Electrophysiology (science);empowerment;Environment;Epilepsy;Event;experience;FDA approved;Feasibility Studies;feasibility trial;Goals;handheld equipment;Heart Rate;Hemorrhage;Hospitals;Implant;Incidence;infection risk;innovation;International;machine learning method;Medical;Methods;Monitor;Motor Seizures;Nature;novel;Patient Monitoring;Patient Recruitments;Patients;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Physicians;Physiological;prevent;Probability;Process;prospective;Publishing;Quality of life;Reporting;Research;Risk;safety and feasibility;safety assessment;Scalp structure;Seizures;Self Administration;sensor;side effect;Signal Transduction;Surrogate Markers;System;targeted treatment;Telemetry;Testing;Time;training data;usability;Vendor;wearable data;wearable device;wearable sensor technology;Work;Wrist

PROJECT_TITLE: Optimizing Pharmacotherapy with Noninvasive Wearable Sensors and Subscalp EEG

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: LEXINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Traumatic brain injury (TBI) is a devastating healthcare problem in the United States with no pharmacological treatments currently approved for clinical intervention; improved TBI treatment options are urgently needed. To address this problem, we are proposing to use a novel 2,4-dinitrophenol prodrug, MP201, across multiple TBI platforms and at different institutions to define its dose-response and therapeutic window of intervention. This proposal is designed to lay the groundwork for translation of MP201 to ameliorate recovery after TBI.

PI_NAMEs: KILBAUGH, TODD JUSTEN;SULLIVAN, PATRICK G (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: 2,4-Dinitrophenol;Acute;Address;Adult;Aging;Anxiety;Axon;Behavior;behavior measurement;behavioral outcome;Bioenergetics;Biological Assay;Biological Markers;Biosensor;biosignature;Blinded;Blood Platelets;Brain;Brain Contusions;Brain Injuries;Chronic;Clinical;Clinical Pharmacology;clinically relevant;Cognition;Cognitive;Cognitive deficits;cognitive testing;Contusions;Data;design;Dinitrophenols;dosage;Dose;Drug Kinetics;efficacy evaluation;experimental study;Family suidae;FDA approved;Female;Goals;Healthcare;Homeostasis;Huntington Disease;Impaired cognition;Impairment;improved;in vivo;Individual;Injury;Inner mitochondrial membrane;innovation;Institution;Intervention;Link;male;Measures;Mediating;Membrane Potentials;Mitochondria;mitochondrial dysfunction;Mitochondrial Matrix;mitochondrial membrane;Morphology;Motor Activity;mouse model;Movement;Mus;neurochemistry;neuroimaging;neurological recovery;Neurons;neuropathology;neuroprotection;neurotropic;novel;novel marker;novel strategies;Outcome;oxidative damage;Oxidative Stress;Pediatric Hospitals;Pharmacodynamics;pharmacologic;Pharmacological Treatment;Pharmacology;Philadelphia;Physiology;porcine model;pre-clinical;Pre-Clinical Model;preclinical efficacy;primary endpoint;Prodrugs;Production;Property;Protons;Publishing;Randomized;Reactive Oxygen Species;Recovery;repaired;residence;response;restoration;Rodent;Scanning;severe injury;sex;spinal cord and brain injury;Stroke;Synapses;TBI treatment;Techniques;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Therapeutic Intervention;Time;Tissues;Translating;translational therapeutics;Translational trial;Translations;Traumatic Brain Injury;Traumatic Brain Injury recovery;Treatment Efficacy;United States;Women's cohort;Work

PROJECT_TITLE: Mitochondrial Uncoupling Prodrug as a Translational Therapy for TBI

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

PHR: PROJECT NARRATIVE This research study, Personalized, Responsive Intervention Sequences for Minimally Verbal Children with Autism (PRISM), is designed to maximize language outcomes for limited-language preschoolers, thereby lowering the risk of being classified as “minimally verbal” at age 6, by empirically developing a two-stage, 20- week adaptive intervention approach in a real world community settings. If found efficacious, the adaptive intervention design will capitalize on the heterogeneity and evolving status of children with ASD by providing the best intervention (DTT, JASPER and CET) for children who need it (leading to individualized sequences of intervention), only when it is needed (potentially reducing burden on children).

PROJECT_TERMS: 4 year old;adaptive intervention;Address;Age;applied behavior analysis;Area;autism spectrum disorder;autistic children;Child;Child Language;Classification;Communication;community setting;Consensus;design;Disease;Early Intervention;Educational workshop;Elements;evidence base;Exhibits;Exposure to;follow-up;Goals;Heterogeneity;improved;Individual;Intervention;Intervention Studies;joint attention;Joints;Knowledge;Language;language outcome;Measures;Mediating;Mediator;minimally verbal;National Institute of Mental Health;Nursery Schools;Oregon;Outcome;Participant;personalized intervention;phrases;Play;Population;Preschool Child;primary outcome;Probability;Recommendation;Regulation;Research;research study;response;Risk;School-Age Population;secondary outcome;Site;skills;social;social communication impairment;Specific qualifier value;Speech;standard of care;Strategic Planning;Terminology;Testing;therapy design;Time;Training;United States National Institutes of Health;verbal


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative  Using structure-based immunogen design we have developed a rational approach to consistently elicit antibodies against the conserved fusion peptide (FP) epitope of HIV envelope glycoprotein (Env), which comprises a broadly neutralizing antibody epitope. Within this project we will further optimize and test our vaccine regimen in NHPs and ultimately test the efficacy by challenging the animals with heterologous low dose repeated viral challenge. Additionally, COVID-19 is an extraordinary public health challenge; over 100,000 Americans have died from COVID-19 so far in 2020. A vaccine is desperately needed to stop this pandemic. We have a COVID-19 vaccine concept, which we can test in parallel in our R01 monkeys without any detriment to the ongoing research, and even provides additional value to our current grant by providing additional data that can serve as controls.

PI_NAMEs: CROTTY, SHANE P;WARD, ANDREW BARRETT (contact)

PROGRAM_OFFICER_NAME: MALASPINA, ANGELA

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Address;Affinity;American;Animals;Antibodies;Antibody Response;Antigens;Attenuated;Autologous;Avidity;B-Cell Antigen Receptor;B-Lymphocytes;base;Bolus Infusion;Cells;Complex;Consensus Sequence;COVID-19;COVID-19 vaccine;Data;deltoid muscle;design;Development;Dose;efficacy testing;Electron Microscopy;Engineering;Epitope Mapping;Epitopes;Experimental Designs;Future;Glycoproteins;Goals;Grant;HIV;HIV envelope protein;HIV vaccine;HIV-1;Human;Image;Immune response;Immune system;Immunization;Immunize;immunogenic;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;Immunologics;improved;Individual;interest;Left;Longitudinal Studies;Mediating;Membrane Glycoproteins;Modeling;Monkeys;nanoparticle;Needles;neutralizing antibody;nonhuman primate;novel;pandemic disease;Pathogenicity;Patients;Peptide antibodies;Peptide Vaccines;Peptides;Pilot Projects;polyclonal antibody;Polysaccharides;programs;protective efficacy;Public Health;Reaction;reconstruction;Regimen;Reproducibility;Research;response;Sampling;Secondary Immunization;self assembly;Series;Serum;simian human immunodeficiency virus;Site;Structure;Structure of germinal center of lymph node;success;Surface;Techniques;Testing;trafficking;vaccination strategy;vaccine candidate;vaccine development;Vaccine Research;vaccine strategy;vaccine trial;Vaccines;Viral;Virus;Wild Type Mouse;Work

PROJECT_TITLE: Fusion peptide directed immunogens that elicit neutralizing and protective antibodies in non-human primates

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative This project efficiently uses a large national registry of total knee replacement (TKR) patients to estimate prevalence of premature use and appropriate use of TKR, and understand the social determinants affecting its utilization. In doing so, we aim to provide new insights that will be useful for ACOs and large health systems aiming to optimize timing of healthcare utilization for their members.

PI_NAMEs: GHOMRAWI, HASSAN  (contact)

PROJECT_TERMS: Address;Adverse effects;Affect;Age;Area;built environment;Caring;Categories;Censuses;Classification;Climacteric;Clinical;cohort;combat;community based practice;Continuity of Patient Care;cost;Cross-Sectional Studies;Data;deprivation;Diabetes Mellitus;disability;Disease;Environment;Ethnic Origin;Food;functional disability;functional group;functional loss;Growth;health care service utilization;Health Service Area;Health Services Accessibility;Health system;Home;hospital services;Hospitals;Household;Housing;improved;Incentives;indexing;Infrastructure;insight;Insurance Carriers;Intervention;Investigation;Investments;Knee;Knee Osteoarthritis;knee replacement arthroplasty;Knowledge;Life;long-standing disparities;longitudinal analysis;Lung infections;Medical;Medicare;Medicare claim;member;minority patient;Nature;Operative Surgical Procedures;Outcome;Pain;pain score;Participant;patient registry;Patients;Pattern;Persons;Policies;Postoperative Period;Predictive Factor;premature;Prevalence;Primary Care;Procedures;Public Policy;Pulmonary Embolism;racial minority;Racial Segregation;radiological imaging;Recovery;recruit;Registries;Risk;Roentgen Rays;Rural;rural area;Sampling;Shapes;Site;social determinants;statistics;Surgeon;surgery outcome;System;Transportation;transportation access;Urban Hospitals;Variant;Western Ontario and McMaster Universities Arthritis Index;Work

PROJECT_TITLE: Social Determinants and Timeliness of Total Knee Replacement: A National Perspective

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE We will develop a first-year-of-life, MRI-based predictive test for later autism spectrum disorder (ASD) diagnosis in a new cohort of infants (N=250) at high familial risk. This project has high public health relevance because of its promise for early, presymptomatic identification of infants who will develop ASD, making possible more efficient presymptomatic intervention studies of those infants at ultra-high risk.

PI_NAMEs: PIVEN, JOSEPH ;PRUETT, JOHN R (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: 2 year old;Affect;Age;Age Months;Appearance;Area;autism spectrum disorder;autism symptoms;autistic;Behavior;Behavioral;Biological Markers;Brain imaging;Categories;Characteristics;Child;Classification;Clinical;clinical predictors;clinical research site;Clinical Trials;clinically relevant;cohort;cost effective;Data;Detection;Development;Diagnosis;Diagnostic;Dimensions;Disease;Early Intervention;Education;Enrollment;Family;Funding;Future;Goals;Health Benefit;high risk;high risk infant;Impairment;Individual;infancy;Infant;Infrastructure;Intervention;Intervention Studies;joint attention;Language;Life;Magnetic Resonance Imaging;Measures;Methods;MRI Scans;neuroimaging;Outcome;Parents;pharmacologic;Population;predictive test;Predictive Value;presymptomatic testing;prospective;Public Health;public health relevance;Publishing;repetitive behavior;research clinical testing;Research Personnel;Rest;Risk;Sample Size;Sampling;Shapes;Siblings;Site;social;success;Surface;Testing;Time;tool;Treatment outcome;Triage;Validation

PROJECT_TITLE: MRI Based Presymptomatic Prediction of ASD


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung

ORG_DEPT: PHARMACOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE  This project aim to identify and characterize highly potent Nbs that are highly resistant to the variants of concern (VOCs) of SARS-CoV-2, investigate the neutralization mechanisms by structural approaches, and develop ultrapotent Nb constructs into safe and effective therapeutics. Our central hypothesis is that Nbs can be bioengineered into multivalent and ultrapotent forms to resist the mutational escape and the variants of concerns (VOCs) of SARS-CoV-2. Completing this project will lead to efficient, cost-effective, and convenient COVID-19 therapeutic candidates that are ready for translation into clinical trials. This project will not only serve as an excellent testbed to assemble the multidisciplinary approaches into a platform for the rapid development of novel and cost-effective therapeutic agents for SARS-CoV-2 and the VOCs but also possibly for a future pandemic.

PI_NAMEs: DUPREX, WILLIAM PAUL;SHI, YI  (contact);ZHANG, CHENG

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;aerosolized;Aerosols;Affinity;Antibodies;Binding;Biological Availability;Biomedical Engineering;Cells;Clinical;clinical application;Clinical Research;Clinical Trials;Communities;Computer software;Coronavirus;cost;cost effective;COVID-19;COVID-19 outbreak;COVID-19 therapeutics;COVID-19 treatment;Deposition;design;Development;Diagnostic Reagent;Dose;drug development;drug quality;Drug Storage;efficacy evaluation;emerging pathogen;Epitope Mapping;Epitopes;Event;flexibility;Future;future pandemic;Genotype;global health;Goals;Hamsters;Human;Immunoglobulin Fragments;Immunoglobulin G;improved;in vivo;Infection;Inhalation;Innovative Therapy;insight;interdisciplinary approach;interest;Lung;manufacture;Microbe;Modeling;multidisciplinary;Mutation;nanobodies;Nebulizer;novel;novel therapeutics;novel vaccines;pandemic disease;pathogen;Pharmaceutical Preparations;preclinical efficacy;preclinical evaluation;prevent;Primates;Production;Property;protein folding;Proteomics;Pulmonary Pathology;rational design;receptor binding;Reporting;Research;Resistance;Resolution;Respiratory System;respiratory virus;SARS-CoV-2 infection;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Science;structural biology;Structure;System;Technology;Therapeutic;Therapeutic Agents;therapeutic candidate;therapeutically effective;translational potential;Translations;variants of concern;Viral;Viral Antibodies;Viral Load result;Viral Pneumonia;Virus

PROJECT_TITLE: Development of multivalent, ultrapotent nanobody cocktails for SARS-CoV-2 neutralization

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Autism;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Intellectual and Developmental Disabilities (IDD);Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative This research project will investigate how environmental and genetic factors may interact in relation to a child’s risk for autism, which means that some children may be affected more than others by environmental chemicals, depending on their mother’s genetics or their own inherited genetics. This research has public health relevance because it can lead to finding ways to prevent autism, particularly for those with certain genes. If we can prevent at least some cases of autism, it will be a victory for children’s public health.

PI_NAMEs: BENNETT, DEBORAH HALL;HERTZ-PICCIOTTO, IRVA  (contact);SCHMIDT, REBECCA JEAN;WALKER, CHERYL KATHERINE

PROGRAM_OFFICER_NAME: LAWLER, CINDY P

PROJECT_TERMS: Address;Affect;Air Pollutants;Air Pollution;autism spectrum disorder;autism symptoms;Behavioral;Biochemical;Biological;blood glucose regulation;Case/Control Studies;Chemicals;Child;comorbidity;Conceptions;Data;Databases;Developmental Delay Disorders;Diabetes Mellitus;Diagnosis;disability;Discipline of obstetrics;Disease;disorder risk;Elasticity;Enrollment;Environment;environmental chemical;Environmental Epidemiology;Environmental Exposure;Environmental Risk Factor;Etiology;exposure pathway;Exposure to;Factor Analysis;Family;Fever;Folic Acid;Fragile X Syndrome;fungicide;gene environment interaction;Gene Modified;General Population;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;Genome;genome wide association study;genome-wide analysis;Genomics;Haplotypes;Immune;Immunity;improved;Individual;Inherited;Intellectual functioning disability;interest;Intervention;intrauterine environment;Ion Channel;Knowledge;lens;Life;Link;Literature;Maternal Health;maternal risk;Measures;Medical;Metabolic;Methods;mitochondrial dysfunction;Mothers;Neurofibromatoses;neuroinflammation;Neurologic;non-genetic;nutrition;Nutritional;Odds Ratio;Ontology;Organophosphates;Outcome;Paper;Parental Ages;Pathogenicity;Pathway interactions;personalized intervention;pesticide exposure;Pesticides;pharmacologic;phase 2 study;Placental Insufficiency;population based;Population Control;Positioning Attribute;postnatal;postnatal period;power analysis;Pre-Eclampsia;precision medicine;Predisposition;Pregnancy Complications;prenatal;prenatal environmental exposure;Prevalence;prevent;proband;Public Health;public health relevance;pyrethroid;rare variant;recruit;Reporting;Research;Research Project Grants;Risk;Risk Factors;Risk Reduction;Sample Size;Sampling;Science;Seizures;Seminal;Severities;sex;Solid;Specimen;Subgroup;Sum;synaptogenesis;Syndrome;Toxic effect;transcriptomics;Variant;WNT Signaling Pathway;Work

PROJECT_TITLE: The CHARGE Study Phase II: A Multifactorial Approach to Autism Etiology


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Clinical Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: Project narrative In this project we will test the effect and mechanism of a newly defined immunomodulatory cytokine, interleukin 37, on immune cells and brain resident cells and tissues of mice and patients with multiple sclerosis. These studies should provide an insight into the potential use of interleukin 37 as a novel and more effective therapy for multiple sclerosis and likely other human autoimmune diseases.

PI_NAMEs: ROSTAMI, A.M.  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Adult;Amphiregulin;Animal Model;Astrocytes;Autoimmune;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;Brain;brain tissue;Cells;Central Nervous System Diseases;clinical application;CNS autoimmunity;conditional knockout;cytokine;Data;Demyelinating Diseases;Demyelinations;Development;Disease;Disease Progression;effective therapy;Endowment;experience;Experimental Autoimmune Encephalomyelitis;Family;Feedback;Genetic Transcription;Human;Immune;Immune response;Immunomodulators;immunoregulation;In Vitro;Individual;Inflammation;Inflammatory;Inflammatory Response;insight;Interleukin-1;Interleukin-10;Interleukin-12;interleukin-23;Interleukins;Knockout Mice;Literature;Lymphocyte;Macrophage;member;Microglia;monocyte;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Mus;Myeloid Cells;neuroinflammation;Neurons;novel;Oligodendroglia;Pathogenicity;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Production;Property;receptor;receptor expression;Regulatory T-Lymphocyte;Relapse;Rodent;Role;Serum;Severities;Signal Transduction;Slice;Source;System;Testing;tissue repair;Tissues;transcription factor;Transgenic Mice;Up-Regulation

PROJECT_TITLE: IL-37: a novel regulator of inflammation in CNS autoimmunity

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Lung;Lung Cancer;Prevention;Rare Diseases;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: SALT LAKE CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Smoking cessation is critically important for cancer patients, however smoking rates are very high in this population and many are unmotivated to quit, especially patients with cancers that are not typically associated with smoking. This study will pilot test a recently developed brief self-help intervention targeted by cancer type to increase smoking cessation motivation and will gather data on contextual factors to inform its future implementation in routine cancer care. The goal is to increase motivation to quit smoking, and ultimately smoking cessation itself among cancer patients.

PI_NAMEs: MARTINEZ PRADEDA, URSULA  (contact)

PROGRAM_OFFICER_NAME: VAHEDI, SHAHROOZ

PROJECT_TERMS: Abstinence;Acute Myelocytic Leukemia;Adherence;Attention;Bladder;Breast;brief advice;cancer care;cancer diagnosis;Cancer Etiology;Cancer Patient;cancer recurrence;cancer risk;cancer site;cancer therapy;cancer type;Cardiovascular Diseases;career;Caring;Cervix Uteri;Cessation of life;Chest;cigarette smoking;Clinic;Colon;Colorectal;complex data;Confidence Intervals;contextual factors;coping mechanism;Counseling;Data;Data Analyses;design;Development;Diagnosis;Effectiveness of Interventions;efficacy testing;Enrollment;Etiology;evidence base;formative assessment;Funding;Future;future implementation;Goals;Gynecologic;Head and Neck Cancer;Head and neck structure;Health;Hybrids;implementation facilitators;implementation intervention;implementation science;implementation strategy;improved;Individual;Intervention;intervention delivery;intervention effect;Link;Lung;Malignant neoplasm of esophagus;Malignant neoplasm of larynx;Malignant neoplasm of liver;Malignant neoplasm of pancreas;Malignant neoplasm of ureter;Malignant Neoplasms;malignant stomach neoplasm;Melanoma;Methods;Modality;mortality risk;Motivation;non-smoking;Nurses;Oncology;organizational readiness;Pamphlets;Participant;patient engagement;Patients;Pattern;Pharmaceutical Preparations;Physicians;pilot test;Population;Primary Neoplasm;Procedures;Prognosis;programs;Provider;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Rectum;Renal Carcinoma;Reporting;Research;Research Design;Research Personnel;Resources;Risk;Risk Factors;Role;routine care;self help;Services;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;Smoking treatment;Source;Specialist;System;Technology;Testing;therapy development;Time;Tobacco;Tobacco smoking behavior;Tobacco use;tracheal cancer;Training;treatment as usual;Treatment Efficacy;Treatment outcome;treatment services;United States

PROJECT_TITLE: Enhancing motivation to quit smoking via self-help intervention targeted to cancer type: A pilot RCT

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: The most persistent and disabling postconcussive symptoms following mild traumatic brain injury (mTBI) are sleep disturbances and cognitive dysfunction, with few tractable interventions currently available. We propose to test a novel therapy consisting of dietary supplementation with branched chain amino acids (BCAA), based on our preclinical work showing restoration of glutamate neurotransmitter balance in sleep and memory circuits. Supplementation with Amino acid Rehabilitative Therapy in TBI (SmART-TBI) is a randomized, placebo-controlled, double-blinded, exploratory clinical trial of BCAA intended to establish the feasibility, acceptability, and limited efficacy of long-term BCAA to improve sleep and cognition in Veterans with mTBI. These results will inform the optimal study design of a future, full-scale randomized controlled trial, including the identification of the proper dose and duration of BCAA to improve sleep and the potential subpopulations of Veterans with mTBI that may benefit the most.

PI_NAMEs: LIM, MIRANDA M (contact)

PROJECT_TERMS: acceptability and feasibility;actigraphy;Address;Adherence;Affect;amino acid therapy;Amino Acids;Brain;brain dysfunction;Branched-Chain Amino Acids;Client satisfaction;Clinical Trials;Cognition;Cognitive;cognitive function;Data;design;Diagnosis;diaries;dietary;Dietary Supplementation;dietary supplements;Disabling;Dose;Double-Blind Method;efficacy outcomes;efficacy study;efficacy trial;Employment;Equilibrium;Failure;feasibility testing;functional improvement;functional outcomes;Future;Glutamates;Goals;Human;Impaired cognition;Impairment;improved;improvement on sleep;Individual;Intervention;Isoleucine;Leucine;Life;Maps;Measures;Memory;Methodological Studies;Methods;mild traumatic brain injury;Mus;Neurotransmitters;novel therapeutics;Oral;Participant;Patient Self-Report;Patients;pharmacologic;Placebo Control;placebo controlled study;placebo group;Placebos;Polysomnography;poor sleep;Post-Concussion Syndrome;pre-clinical;prevent;Quality of life;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;recruit;Rehabilitation Outcome;Rehabilitation therapy;Research;Research Design;response;restoration;Route;Safety;Sampling;Serum;side effect;Sleep;Sleep Disorders;Sleep disturbances;sleep quality;Structure;Supplementation;Symptoms;Testing;treatment group;Valine;Veterans;Work

PROJECT_TITLE: Supplementation with Amino Acid Rehabilitative Therapy in TBI (SmART-TBI): A Randomized Placebo-Controlled Trial to Improve Sleep


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer death worldwide, with KRAS being the most frequently mutated “driver” gene. Utilizing a state-of-the-art preclinical platform, this proposal aims to explore the therapeutic potential of targeted degradation of KRAS oncoproteins alone and in combination of immunotherapy in NSCLC, and dissect the underlying mechanisms associated with antitumor immunity.

PI_NAMEs: ZHANG, HUA  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Address;antagonist;anti-PD-1;Antibodies;Antigen Presentation;antitumor effect;Cancer Etiology;career development;Career Transition Award;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Cells;Cessation of life;chemokine;Clinical;Clinical Trials;cohort;Combination immunotherapy;Comprehensive Cancer Center;Computational Biology;cytokine;Data;Dendritic Cells;design;Development;Educational workshop;efficacy evaluation;efficacy testing;Enrollment;Environment;Evaluation;Genes;Genetic Transcription;Genetically Engineered Mouse;Goals;Human;Immune;immune cell infiltrate;Immune response;Immunologics;Immunotherapy;immunotherapy clinical trials;improved;In Vitro;in vivo;individualized medicine;Inflammatory;inhibitor;insight;Interdisciplinary Study;Intrinsic factor;KRAS oncogenesis;KRAS2 gene;Laboratory Research;Lung Adenocarcinoma;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;meetings;Modeling;Molecular;mutant;Mutate;Mutation;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;Oncogenes;Oncogenic;Oncoproteins;Organoids;Outcome;Patients;Population;pre-clinical;Pre-Clinical Model;Predisposition;programs;Progression-Free Survivals;Protac;protein degradation;Proteins;Research;Resistance;response;single-cell RNA sequencing;System;Testing;Therapeutic;tool;transcriptomics;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;United States Food and Drug Administration;Variant

PROJECT_TITLE: Targeted degradation of KRAS oncoproteins triggers antitumor immunity and abolishes lung tumor

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-R (O1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: COLUMBIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: Narrative  The objective of this project is to characterize the effects of repeated influenza vaccination on the specificity of cross-reactive antibodies and on influenza vaccine performance. The study findings will enable optimization of influenza vaccine performance by expanding our understanding of molecular mechanisms involved in the effect of repeated influenza vaccination on vaccine performance and by providing basic knowledge to evaluate the need for annual influenza vaccination.

PI_NAMEs: WAN, XIUFENG HENRY (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Address;Affect;Age Months;Antibodies;Antibody Avidity;Antibody titer measurement;antigen detection;Antigenic Diversity;Antigenic Variation;Antigens;B-Lymphocytes;base;Biological Assay;CD4 Positive T Lymphocytes;Cells;Confusion;cross reactivity;Disease Outbreaks;Economics;Effectiveness;egg;Ensure;epidemiology study;Evaluation;Female;Ferrets;Frequencies;Goals;Health;Human;Immune response;Immunity;Impairment;improved;Individual;Infection;Infection prevention;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;influenza infection;influenza outbreak;Influenza prevention;Influenza vaccination;influenza virus vaccine;influenzavirus;Knowledge;Letters;Ligation;male;Mediating;military health system;Modeling;Molecular;Mutation;National Institute of Allergy and Infectious Disease;pandemic disease;Pathology;Pattern;Performance;Persons;Public Health;Reaction;Recommendation;Reporting;response;Role;Sampling;seasonal influenza;Seasons;Serology test;seropositive;Serum;Severities;sex;Specificity;Strategic Planning;T-Lymphocyte;Testing;United States;universal influenza vaccine;unvaccinated;Vaccinated;Vaccination;vaccine effectiveness;vaccine efficacy;Vaccinee;Vaccines;Variant;viral transmission;Virus;Virus Shedding

PROJECT_TITLE: Impact of repeated vaccination on the effectiveness of seasonal influenza vaccines

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Neurodegenerative;Neurosciences;Patient Safety

PHR: Project Narrative This project will develop and evaluate the next generation of flexible, high-resolution, implantable, liquid crystal polymer thin-film (LCP-TF) electrode arrays for neurological interventions under a traditional 510(k) premarket notification. The LCP-TF electrodes will be developed to safely measure neural signals over large areas of the brain at fine resolution and evaluate their potential to improve the diagnosis and treatment of neocortical epilepsy. The results of this project will have direct and immediate impact on the clinical community through the use of the traditional 510(k) mechanism, advance the standard of care for epilepsy diagnosis, and enable the future development of novel implantable devices to diagnose and treat a range of neurological disorders.

PI_NAMEs: BHANDARI, RAJMOHAN ;FRIEDMAN, DANIEL  (contact);PESARAN, BIJAN ;SOLZBACHER, FLORIAN ;VIVENTI, JONATHAN

PROJECT_TERMS: Acceleration;Advanced Development;Affect;American;Animal Model;Area;Biology;biomaterial compatibility;Brain;Clinical;clinical trial enrollment;Clinical Trials;Collaborations;Communities;computerized data processing;Computers;cost;Data;data acquisition;data visualization;density;Development;Device Approval;Device Designs;Device Safety;Devices;Diagnosis;Diagnostic;diagnostic value;Disease;Drug resistance;Edema;Effectiveness;Electrocorticogram;Electrodes;Engineering;Epilepsy;Excision;Face;Failure;FDA approved;Film;flexibility;Freedom;Frequencies;Future;Hemorrhage;Human;Implant;implantable device;implantation;improved;Individual;Industrialization;Inflammation;Infrastructure;interest;Intervention;Intractable Epilepsy;large scale data;Length of Stay;liquid crystal polymer;Location;manufacture;Marketing;Measurement;Measures;Medical;medical schools;meter;Microelectrodes;microstimulation;microsystems;miniaturize;Modernization;Monitor;Morbidity - disease rate;Morphologic artifacts;mortality;Multi-Institutional Clinical Trial;Neocortex;neocortical;Nervous System Disorder;neural;neuroinflammation;Neurologic;Neurosurgical Procedures;neurotransmission;New York;next generation;Noise;nonhuman primate;Notification;novel;Operative Surgical Procedures;Outcome;Pain;Partial Epilepsies;patient safety;patient tolerability;Patients;Pattern;Performance;personalized approach;personalized medicine;Phase;Play;Preclinical Testing;prototype;Randomized;Records;research clinical testing;Resistance;Resolution;retina implantation;Risk;Rodent;Role;Safety;Sales;Sampling;Scientific Advances and Accomplishments;Scientist;Seizures;Signal Transduction;Site;standard of care;Statistical Data Interpretation;Sterilization;success;Surveys;Swelling;System;Technology;Testing;Therapeutic;Thick;Thinness;Tissues;Translating;Universities;Utah;Work

PROJECT_TITLE: Advancing Epilepsy Diagnosis with Flexible, High-Resolution Thin-Film Electrodes


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Diabetes;Rural Health;Social Determinants of Health

ORG_CITY: ATHENS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OHIO UNIVERSITY ATHENS

ORG_STATE: OH

PHR: Project Narrative: Health disparities in diabetes and its complications are well-documented among racial and ethnic minorities and people from rural Appalachia. Considering the high rates of diabetes in disadvantaged populations and the changing demographics of our country, higher education must promote diversity and inclusion at the graduate student and faculty ranks. The DISIRE program is dedicated to recruiting talented undergraduates from minority serving institutions, small liberal arts colleges, and Appalachian universities to prepare the next generation of basic and clinical researchers in diabetes.

PI_NAMEs: KOPCHICK, JOHN JOSEPH (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Academic advising;Acceleration;Admission activity;Appalachian Region;Applied Research;apprenticeship;Awareness;Back;Basic Science;bench to bedside;bench-to-bedside translation;Biological Sciences;career;certificate program;Chemistry;Clinical;clinical care;college;Communities;community engagement;Community Outreach;Country;Critical Thinking;Dedications;demographics;design;Development;Diabetes Mellitus;Disabled Persons;disabled students;Disparity population;diversity and inclusion;Education;educational atmosphere;Educational Curriculum;Engineering;Ensure;Environment;Equity;ethnic minority;experience;Exposure to;Faculty;Fostering;fundamental research;Future;Generations;Genetic;Goals;Graduate Degree;graduate school;graduate student;health disparity;Health Occupations;Health Sciences;higher education;Hour;Immersion;improved;Individual;innovation;Institution;Instruction;interdisciplinary collaboration;Intervention;Journals;Knowledge;Learning;Managed Care;member;Mentors;Metabolism;Microbiology;minority student;minority undergraduate;Minority-Serving Institution;Mission;Molecular;next generation;novel strategies;Nutritional Science;Ohio;online course;Osteopathic Medicine;Outcome;Participant;participant retention;Pathway interactions;patient engagement;Physiology;Population;prevent;Prevention strategy;Problem Solving;Process;Program Evaluation;programs;Psychosocial Assessment and Care;Qualifying;racial minority;recruit;Research;Research Personnel;Research Project Grants;Research Training;Resources;response;Rural Appalachia;Rural Population;Schools;Science;Self Care;Self Efficacy;Site;skills;social media;Structure;summer institute;summer program;symposium;Talents;Testing;Training;Translational Research;undergraduate research experience;undergraduate student;Underrepresented Minority;Underrepresented Students;Universities;university student;Vision;Work

PROJECT_TITLE: Diabetes Institute Summer Interprofessional Research Experience (DISIRE) for Undergraduates

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - B;Human Genome;Infectious Diseases;Liver Disease;Racial and Ethnic Minority Health Research

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Chronic infection with hepatitis B virus (HBV) is the leading cause of liver-related morbidity and mortality worldwide and is common in persons living with HIV (PLWH). Current treatment inhibits viral replication but cannot cure the infection. Understanding the genetic basis for recovery from a hepatitis B virus (HBV) infection in persons with and without HIV infection may inform development of a functional cure for HBV.

PI_NAMEs: DUGGAL, PRIYA ;THOMAS, DAVID L (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Acute Hepatitis;Admixture;Affect;Africa;African;African ancestry;Alleles;Amino Acids;Anti-viral Agents;Antibodies;antigen test;Antigens;Asian;Asian ancestry;Asian population;biobank;Blood;Candidate Disease Gene;Cell Nucleus;Chinese;Chinese population;Chromosomes;Chronic Hepatitis;Chronic Hepatitis B;chronic infection;Circular DNA;Cirrhosis;cohort;Collaborations;Data;deep sequencing;Detection;Development;DNA;Drug Controls;end stage liver disease;Ethnic Origin;European;European ancestry;Exclusion;Family Study;Frequencies;Funding;Gene Frequency;Genes;Genetic;genetic association;Genetic Determinism;genetic variant;genome wide association study;genome-wide;genome-wide analysis;genomic data;genomic locus;Genomics;Goals;Hepatitis B;Hepatitis B e Antigens;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Virus;Hepatitis C virus;Hepatocyte;HIV;HIV Infections;Human;Human Genetics;Human Genome;Immune;Immune response;Immunity;Immunologics;Immunology;Individual;Infection;insight;International;Knowledge;Liver;Liver diseases;Malaria;Measures;Meta-Analysis;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;next generation sequencing;North America;novel;Pathway interactions;Persons;pharmacologic;Phenotype;Population;Primary carcinoma of the liver cells;primary outcome;Procedures;Public Health;Quality Control;Recovery;Risk;secondary outcome;Serology;Serology test;Single Nucleotide Polymorphism;Site;skills;Structure;Testing;Translating;Trust;Tuberculosis;Viral;viral DNA;Viral Genome;viral genomics;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Human Genetic determinants of HBV recovery

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PI_NAMEs: OHNO-MACHADO, LUCILA  (contact)

PROGRAM_OFFICER_NAME: WELLINGTON, CHRISTOPHER

PROJECT_TERMS: Address;Adoption;Adverse effects;Authorization documentation;Binding;blockchain;Collaborations;Computer software;Confidentiality of Patient Information;Consent;consent management systems;Contracts;Credentialing;Data;data de-identification;Data Mart;data modeling;Data Science;Data Security;data sharing;Data Sources;Decentralization;design;Educational workshop;electronic consent;Electronic Health Record;electronic structure;Encapsulated;Ensure;experience;experimental study;Focus Groups;genetic information;Genome;Goals;Grant;graphical user interface;Health;Health system;Image;Infrastructure;Institution;Institutional Review Boards;Internet;Interview;Knowledge;Laws;Medical center;Metadata;Methods;Modeling;Notification;Outcome;Participant;Patient Preferences;Patient Recruitments;Patients;Policies;preference;Privacy;Privatization;Process;Records;Regulation;Research;Research Personnel;research study;Resources;risk minimization;Sampling;Science;Scientific Advances and Accomplishments;Security;simulation;Site;software systems;Strategic Planning;Structure;Surveys;synthetic data;System;Technology;Testing;tool;Trust;United States National Institutes of Health;usability;waiver

PROJECT_TITLE: iAGREE: A Multi- Center, Networked Patient Consent Study

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Disability Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Pregnancy

ORG_DEPT: PSYCHIATRY

PHR: To better understand the neurobiological and molecular underpinnings of autism spectrum disorder, a first goal of this application is to develop a nonhuman primate model through genetic modification of the CHD8 gene. This gene is among the most frequently mutated genes in individuals with ASD. A long- term goal is to establish infrastructure to enable the generation of genetically modified monkeys for translational biomedical research - which we believe to be in the national interest.

PI_NAMEs: AMARAL, DAVID G (contact);VANDEVOORT, CATHERINE A

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Affect;Affective;Age;Animal Model;Animals;Attention;autism spectrum disorder;Behavioral;Biological Assay;Biological Factors;Biology;Biomedical Research;Biopsy;Brain;California;Characteristics;Child;Childhood;Chromatin;Clinical;Clinical Trials;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;cognitive disability;cost effective;Cost efficiency;CRISPR/Cas technology;Data;Development;Disease;Electroporation;Embryo;embryo cell;embryo cryopreservation;Embryo Transfer;Etiology;experience;Fetus;First Pregnancy Trimester;Functional Magnetic Resonance Imaging;Funding;gene function;Gene Modified;gene-editing approach;Generations;Genes;Genetic;genetic approach;genetic manipulation;Genetic Research;Genetically Modified Organisms;Goals;Growth;Guide RNA;Health;Human;implantation;improved;Individual;individuals with autism spectrum disorder;Infrastructure;interest;Intervention;Leadership;Live Birth;loss of function;loss of function mutation;Macaca mulatta;Macrocephaly;Measurement;Medical;Megalencephaly;Methodology;Microinjections;model of autism spectrum disorder;Modeling;Modification;Molecular;Monitor;Monkeys;Mothers;Motor;mouse model;multimodality;Mus;mutant;Mutate;Mutation;Neonatal;Neurobiology;Neurodevelopmental Disorder;nonhuman primate;offspring;Oocytes;Phase;Phenocopy;Phenotype;Positioning Attribute;preference;Pregnancy;Primates;Production;programs;Proteins;Reflex action;Research;Research Personnel;Rest;RNA;Rodent;Rodent Model;Route;Sampling;Series;sex;social;Social Behavior;Social disability;Stimulus;success;Techniques;Third Pregnancy Trimester;Time;United States;Validation;Variant;Weight

PROJECT_TITLE: Genetic Strategies for Neurodevelopmental Research


NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Narrative This program aims to increase the diversity of the environmental and health research workforce and ensure that future generations of environmental health researchers and public health practitioners come from the entire pool of talented individuals, including underrepresented minorities, persons with disabilities, and the socioeconomically challenged. The goals and objectives are designed to provide undergrad students who have an early interest in environmental health, with the opportunity to engage in cutting-edge high quality research and educational opportunities that can be influential in their personal development and professional careers.

PI_NAMEs: NAVAS-ACIEN, ANA  (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Achievement;Admission activity;Behavioral Sciences;career;Cohort Effect;Complex;Critical Thinking;Data Analyses;design;Development;disability;Disabled Persons;Discipline;Economics;Education;education research;Educational Activities;Ensure;Environmental Health;Environmental Science;Epidemiology;ethnic diversity;Ethnic Origin;experience;Faculty;faculty mentor;Feedback;Funding;Future Generations;Gender;Goals;graduate school;Health;health science research;Health Sciences;Individual;Influentials;Institution;interest;Knowledge;Letters;Location;Medical;Medical center;Mentors;Methods;minority undergraduate;National Institute of Environmental Health Sciences;New York City;Oral;Participant;Persons;Planet Earth;Positioning Attribute;Process;programs;Psychology;Public Health;Public Health Schools;Race;Research;Research Personnel;Research Project Grants;response;Running;Science;Secure;Sex Orientation;skills;socioeconomics;Sociology;Solid;student participation;Students;success;Supervision;symposium;Talents;Training;Training Activity;training opportunity;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Undergraduate Research Program to Promote Diversity in EHS


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Immunotherapy;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE  Schistosomiasis is a major tropical parasitic disease caused by trematode worms of the genus Schistosoma. The etiopathology of schistosomiasis results from an inflammatory response to the tissue-trapped parasite eggs. Studies in this proposal are designed to elucidate the mechanisms of action of novel players that prevent excessive inflammation and tissue damage in schistosomiasis.

PI_NAMEs: KALANTARI, PARISA  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: adaptive immune response;Address;Aftercare;Agonist;Anti-Inflammatory Agents;Antigen-Presenting Cells;Antigens;Area;Binding;Bone Marrow;Bypass;C Type Lectin Receptors;CD4 Positive T Lymphocytes;cell mediated immune response;Cell Shape;cell type;Cells;Cessation of life;Chromatin;Coculture Techniques;Cyclic GMP;cytokine;Data Set;Dendritic Cells;design;Detection;Development;Dinucleoside Phosphates;Disease;DNA;Drug resistance;egg;Elements;experimental study;Fibrosis;Flow Cytometry;Future;gastrointestinal symptom;Gene Expression Profile;Genetic Transcription;Goals;Granuloma;Granulomatous;Hemorrhage;Hepatic;Hepatosplenomegaly;Human;human disease;IFNAR1 gene;IL17 gene;Immune;Immune response;immunopathology;in vitro testing;in vivo;Inbred CBA Mice;Infection;Inflammation;Inflammatory;Inflammatory Response;innate immune mechanisms;Innate Immune Response;innovation;insight;Interferon Type I;Intestines;IRF3 gene;Lesion;Liver;LoxP-flanked allele;Mass Spectrum Analysis;Mediating;Minority;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;next generation sequencing;novel;Parasite resistance;Parasites;Parasitic Diseases;Pathogenicity;Pathology;Pathway interactions;Patients;Periodicity;pharmacologic;Play;Polysaccharides;prevent;promoter;Reaction;Recurrence;Reporter;Reporting;Research;response;restraint;Role;Schistosoma;Schistosoma mansoni;Schistosomiasis;sensor;Severities;Shapes;Signal Transduction;Site-Directed Mutagenesis;Stimulator of Interferon Genes;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Th2 Cells;Tissues;transcription factor;transcriptome;transcriptome sequencing;treatment strategy;Vaccines;Variant;Vertebrates;Widespread Disease

PROJECT_TITLE: STING-Dependent Pathways Restraining Severe Schistosome Immunopathology

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Patient Safety;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: Linthicum Heights

ORG_NAME: REHABTEK, LLC

PHR: Although early intensive sensorimotor rehabilitation post-stroke is critical in improving functional outcomes and minimizing disability, acute stroke survivors often receive little active training to improve mobility during their hospital stay and they are left alone during most of the day, especially for those patients with no voluntary motor output, partly due to a lack of rehabilitation protocols and practical devices to detect potential motor recovering signals sensitively and facilitate neuroplastic training. The proposed project will develop a novel wearable rehabilitation robot suitable for in-bed acute stage rehabilitation with sensitive detection of the patient’s re- emerging motor output, guided motor relearning with real-time feedback, and passive and active motor-sensory rehabilitation early in the acute stage post-stroke including patients who are paralyzed with no motor output.

PI_NAMEs: LI, SHENG ;REN, YUPENG  (contact);ZHANG, LI-QUN

PROGRAM_OFFICER_NAME: ROBINSON SCHWARTZ, SARAH ELIZABETH

PROJECT_TERMS: Acute;acute stroke;Address;Admission activity;Adult;Aftercare;Ankle;Articular Range of Motion;Beds;Clinical;clinical outcome measures;clinical trial readiness;Clinical Trials;Clinical Trials Design;Computer software;Control Groups;critical period;Data;Detection;Devices;disability;Equilibrium;experience;Feedback;functional improvement;functional outcomes;Goals;Guidelines;hemiparesis;Hemiplegia;Hour;Impairment;improved;improved mobility;Inpatients;Isometric Exercise;Joints;Learning;Left;Length of Stay;Locomotion;Lower Extremity;Manuals;Medical;Motion;Motor;motor control;motor impairment;Motor output;motor recovery;Movement;multimodality;Muscle;neurological rehabilitation;Neuromechanics;Neuronal Plasticity;novel;Outcome;Outcome Measure;Paralysed;Patient Education;Patients;Persons;Phase;phase 1 study;post stroke;Procedures;Protocols documentation;prototype;Quality of life;Recommendation;Recovery;Rehabilitation device;Rehabilitation therapy;Robot;robot assistance;robot rehabilitation;Robotics;Safety;Sensory;Signal Transduction;Small Business Innovation Research Grant;spasticity;Step training;Stretching;Stroke;stroke rehabilitation;stroke survivor;Testing;Therapeutic;Time;Torque;Training;Treatment outcome;United States;wearable device;working group

PROJECT_TITLE: Facilitating neuroplastic changes of acute stroke survivors with severe hemiplegia


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: Newark

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Individuals are capable of integrating multisensory information, such as audible words and visible facial expressions during social communication, and then responding with unique and appropriate behaviors in real time. In humans, inappropriate multisensory processing and real-time response occurs in many developmental disorders, such as autism, sensory processing disorder, ADHD, Tourette’s syndrome, and psychosis, as well as in older adults who experience falls and dementia. This study aims to reveal how brain cells and circuits give rise to dynamic behaviors in response to multisensory stimuli, laying the foundation for long-term understanding of normal and disordered sensorimotor function.

PI_NAMEs: NORMAND, EDNA  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Afferent Neurons;Animals;Attention deficit hyperactivity disorder;Auditory;autism spectrum disorder;Behavior;Behavioral;behavioral response;Biological Assay;Brain;brain cell;Brain region;Calcium;career;Cells;Communication;Complex;connectome data;court;Courtship;Cues;Data Set;deep learning;Dementia;developmental disease;Disease;Doctor of Philosophy;driving behavior;Drosophila genus;Drosophila melanogaster;Electron Microscopy;Environment;experience;Facial Expression;falls;feature detection;Female;Fire - disasters;fly;Foundations;Genetic;Gilles de la Tourette syndrome;Goals;Human;Image;in vivo calcium imaging;Individual;insight;Instinct;Joints;Laboratories;Left;male;Measurable;Methods;Modality;Modeling;Motor;motor behavior;multimodality;multisensory;neural circuit;neuronal circuitry;Neurons;novel;older adult;optogenetics;Physicians;postsynaptic;Preparation;presynaptic;Process;programs;Property;Psychoses;Reaction Time;Resolution;response;Role;Scientist;Sensorimotor functions;Sensory;sensory integration;sensory processing disorder;sensory stimulus;Signal Transduction;social communication;Social Interaction;spatiotemporal;Stereotyping;Stimulus;Synapses;Testing;Time;tool;Training;treadmill;two-photon;virtual reality;Vision;Visual

PROJECT_TITLE: Multisensory integration at the cell, circuit, and behavioral levels: How audiovisual signals drive dynamic courtship behavior in Drosophila melanogaster


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Infections caused by pathogenic Neisseria impose a significant burden on public health. Asymptomatic infections, a common outcome of Neisseria-host interaction, contribute to disease but are poorly understood; these infections may have roots in commensal Neisseria niche development and maintenance behaviors. This project will dissect the mechanisms driving pathogenic Neisseria asymptomatic carriage through the study of host interaction factors shared between commensal and pathogenic Neisseria using an in vivo model of long-term asymptomatic carriage.

PI_NAMEs: RHODES, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Affect;Anabolism;Animal Model;Automobile Driving;Bacteria;bacterial community;Behavior;Biochemical;Biology;capsule;career development;Cell Wall;Cells;Cytoprotection;Data;design;Detection;Development;Disease;Educational workshop;emerging antimicrobial resistance;Environment;Ethics;Exclusion;Foundations;Future;Genes;genetic approach;Genetic Transcription;Goals;Gonorrhea;Grant;Homologous Gene;Human;Hypothetical Protein;immunoregulation;improved;In Vitro;in vivo;in vivo Model;Infection;infection management;insight;Intervention;Knowledge;Laboratories;Laboratory mice;Libraries;Link;Lipoproteins;Maintenance;Male urethral structure;Manuscripts;Mediating;Medical;Mentorship;Methods;Microbial Biofilms;Modeling;monolayer;mouse model;Mucous Membrane;Mus;Mutagenesis;mutant;Neisseria;Neisseria gonorrhoeae;Neisseria meningitidis;novel;novel vaccines;Nutrient;Open Reading Frames;Outcome;pathogen;Pathogenicity;Pathway interactions;Patients;Persons;Pilum;Play;Polysaccharides;Positioning Attribute;Prevention;Process;Protein Secretion;Proteomics;Public Health;Research;resident commensals;Role;Schedule;screening;Signal Induction;Signal Transduction;Stress;Structure;Surface;Symbiosis;Symptoms;System;Testing;tool;Training;transmission process;validation studies;Virulence;Virulence Factors;virulence gene;women subjects;Writing

PROJECT_TITLE: Characterization of Neisseria factors required for asymptomatic carriage

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]