ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Telehealth;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE After a sexual assault, peers often express confusion about how to best support survivors and may encourage drinking to cope, which can exacerbate the wide range of physical and mental health problems survivors experience, contributing to persistent distress, long-term healthcare costs, and loss of productivity. The current project involves the design and feasibility testing of a novel web-based intervention to increase effective peer support of survivors by focusing on behaviors incompatible with heavy drinking, which will in turn reduce alcohol use and related consequences within high-risk social networks of sororities. If feasibility and preliminary intervention effects are supported, this intervention could be widely disseminated and facilitate change in drinking norms among social networks of young adults, as well as mitigate distress after sexual assaults.

PI_NAMEs: JAFFE, ANNA E. (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Affect;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol misuse prevention;alcohol research;Alcohols;Altruism;assault;Awareness;Baseline Surveys;Behavior;Behavioral;brief intervention;Characteristics;Childbirth;Clinical;Cluster randomized trial;college;college drinking;Communication;Communities;community collaboration;Confusion;coping;Data;data cleaning;data management;design;Development;Distress;Documentation;drinking;Educational Intervention;efficacy testing;Emotional;Enrollment;Ensure;Evaluation;Event;experience;feasibility testing;follow-up;Foundations;Friends;Goals;Grant;Health Care Costs;Heavy Drinking;high risk;high risk population;indicated prevention;Individual;innovation;Intervention;intervention effect;K-Series Research Career Programs;Lead;Life;Light;Maintenance;Manuscripts;member;Mental Health;Mentors;Methods;Mission;Modeling;National Institute on Alcohol Abuse and Alcoholism;normative feedback;novel;online delivery;Online Systems;Participant;payment;peer;peer networks;peer support;physical conditioning;Play;post-traumatic stress;Preparation;productivity loss;programs;prototype;psychoeducation;Public Health;Randomized;Reaction;Recovery;recruit;reduced alcohol use;Relaxation;Reporting;Research;Research Personnel;Research Support;Research Training;Resources;Role;Scientist;services as usual;sexual assault;Site;skills training;social movement;Social Network;Students;substance use;Surveys;Survivors;Technology;technology intervention;Testing;therapy design;therapy development;Time;Training;Training Activity;Trauma;Trauma recovery;Uncertainty;web-based intervention;Woman;Writing;young adult

PROJECT_TITLE: Leveraging Social Networks to Promote Sexual Assault Recovery and Reduce Drinking to Cope through a Web-Based Intervention

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: NEW ORLEANS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Narrative We will evaluate the effects of the Medicaid postpartum coverage extension in Louisiana and Mississippi, and postpartum depression screening mandate in Louisiana, compared to Arkansas. The intended outcome will be to evaluate the effectiveness and contextual factors of implementation strategies that aim to improve maternal postpartum health and health equity. This study will generate urgently needed data on practical, robust, and sustainable population-targeted strategies to improve maternal health outcomes, reduce maternal health risks, and eliminate maternal health disparities in the United States.

PI_NAMEs: BIGGIO, JOSEPH RAMON;HARVILLE, EMILY WHEELER (contact);PEREZ, SUSAN

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Administrative Supplement;Adopted;Affect;American;Arkansas;beneficiary;Birth;Blood Glucose;Blood Pressure;Blood Pressure Monitors;Caring;Collaborations;Complex;contextual factors;Cost Analysis;cost effectiveness;cost estimate;Data;Depression screen;Diabetes Mellitus;Diagnosis;Disparity;effectiveness evaluation;effectiveness measure;Electronic Health Record;empowerment;Equity;experience;follow-up;Funding;Future;Gestational Diabetes;glucose monitor;Goals;Health behavior and outcomes;health care delivery;health care service utilization;health disparity;health equity;health inequalities;Health Policy;Hypertension;implementation strategy;improved;Individual;Link;Louisiana;Maternal Health;Maternal health equity;Measures;Medicaid;Mental disorders;Mental Health;Mississippi;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Patients;Persons;Policies;Postnatal Care;postpartum care;Postpartum Depression;postpartum health;Postpartum Period;Pregnancy;pregnancy hypertension;Provider;Recommendation;Risk;Risk Factors;screening;social;Target Populations;United States

PROJECT_TITLE: RP3 Administrative Supplement - UAMS - evaluating the effectiveness and cost-effectiveness of Medicaid postpartum coverage extensions (MPE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(71)-R]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health;Telehealth

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Anterior eye segment diseases such as cataract, refractive error, and corneal opacity are leading causes of global blindness, particularly in low- and middle-income countries. In order to improve access to anterior eye disease screenings in rural settings, our project aims to develop and validate a smartphone-based, community health worker-led platform to screen patients for common anterior eye diseases. We will compare performance of ophthalmologists’ remote grading of smartphone screening data to the gold standard of in-person eye camp exams; we will also compare performance of a machine learning algorithm trained using smartphone screening data and images to the gold standard of in-person eye exams.

PI_NAMEs: PARIKH, KUNAL SAILESH;SHEKHAWAT, NAKUL  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: acceptability and feasibility;algorithm training;Algorithms;Anterior;Anterior eyeball segment structure;Artificial Intelligence;Award;Biomedical Engineering;biomedical referral center;Biometry;blind;Blindness;Calendar;care delivery;care providers;Caring;Cataract;Cellular Phone;Clinical Data;Collaborations;collaborative trial;Communities;Community Health Aides;Computer software;Continuity of Patient Care;Corneal Opacity;cost;cost effectiveness;Data;Data Collection;data platform;Data Set;deep neural network;Dependence;design;Development;Devices;Diagnosis;Diagnostic;Disease;effectiveness evaluation;Ensure;Epidemiology;Equipment;Eye;Eye diseases;Failure;follow-up;Geography;Health;Health system;Health Technology;Healthcare;Hospitals;Human Resources;Image;Improve Access;improved;India;Information Technology;Infrastructure;innovative technologies;interoperability;Intervention;low and middle-income countries;Machine Learning;machine learning algorithm;member;mHealth;Modeling;novel;ophthalmic examination;Ophthalmologist;Ophthalmology;Outcome;patient screening;Patients;Pattern;Performance;Periodicals;Persons;Phase;prototype;Public Health Practice;Quality Control;Refractive Errors;remote communities;remote grading;Research;Research Personnel;Resource-limited setting;Rural;rural patients;rural setting;screening;skills;smartphone based device;Specialist;Standardization;System;Time;Training;Translating;Universities;user centered design;user-friendly;Validation;Visually Impaired Persons;Vulnerable Populations

PROJECT_TITLE: Smartphone-based community screening for eye disease in rural India

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-K(55)]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;HIV/AIDS;Heart Disease;Infectious Diseases;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Persons living with HIV face a higher than expected risk of cardiovascular disease for unknown reasons. This proposal will help to identify mechanisms that are associated with this increased risk which can identify novel interventions to reduce CV risk as well as have a beneficial impact on HIV disease and other comorbidities.

PI_NAMEs: HSUE, PRISCILLA Y. (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: aged;Anti-Inflammatory Agents;aptamer;Atherosclerosis;Award;Basic Science;Biological;Blood Cells;Blood Vessels;Bone Marrow;burden of illness;Cardiology;Cardiovascular Diseases;cardiovascular disorder risk;career;career development;Chronic;Clinic;Clinical;clinical center;Clinical Data;clinical predictors;Clinical Research;Clinical Trials;comorbidity;Coronary heart disease;Data;Development;disability-adjusted life years;Disease;Event;Extramedullary Hematopoiesis;Face;fluorodeoxyglucose positron emission tomography;follow-up;Foundations;Funding;General Population;Goals;Grant;Heart failure;Hematopoiesis;Hematopoietic stem cells;Hematopoietic System;hematopoietic tissue;HIV;HIV Infections;Image;immune activation;improved;Individual;Inflammation;Inflammatory;inflammatory marker;Infrastructure;inhibitor;Interleukin-1 beta;Intervention;Investigation;Kidney Diseases;Laboratories;Leadership;Link;Lipids;lymph nodes;Malignant Neoplasms;Mentors;Meta-Analysis;Metabolic;Monoclonal Antibodies;mortality;multidisciplinary;Mutation;novel;Older Population;Pathogenesis;Pathway interactions;patient oriented;patient oriented research;Persons;PET/CT scan;Play;Prevalence;prevent;Process;progenitor;protein biomarkers;Proteins;proteomic signature;Proteomics;Publications;Pulmonary Hypertension;Reporting;Research;Research Personnel;Resources;Risk;Risk Factors;Role;Sampling;San Francisco;Science;Site;Somatic Mutation;stem cells;sudden cardiac death;Technology;Time;Training;Translational Research;translational research program;translational study;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Role of Hematopoietic System and Proteomics in HIV-Associated CardiovascularDisease

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Asthma;Biotechnology;Genetics;Health Effects of Indoor Air Pollution;Human Genome;Lung

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE WHO estimated that 20% of the world’s population suffer from respiratory allergies and derived diseases such as allergic rhinitis and asthma. However, there is still no clear answer to the question: “why do only some people develop allergy?”, underscoring the need to revisit our understanding of immune mechanisms of allergy. Using novel genomics unbiased tools, we discovered a new type of T cells, we called THIFNR cells, that may play an important role in preventing pathogenic inflammation in allergy and asthma. This grant aims to first complete the characterization those THIFNR cells. First, we will use animal models of respiratory allergy to understand how THIFNR cells function in vivo. Second, we will use single-cell genomics tools to dissect the molecular mechanisms responsible for the development and persistence of THIFNR cells. If successful, our work will provide novel mechanistic insights that may lead to the development of better therapeutic options for patients with allergic diseases.

PI_NAMEs: SEUMOIS, GREGORY  (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: 2019-nCoV;Address;Adoptive Transfer;airway inflammation;Allergens;Allergic;allergic airway inflammation;Allergic Disease;Allergic inflammation;allergic response;Allergic rhinitis;Animal Model;Asthma;asthma model;asthmatic;ATAC-seq;Automobile Driving;Bioinformatics;Blood;CD4 Positive T Lymphocytes;Cell Death;Cell Physiology;Cells;Characteristics;chromatin immunoprecipitation;Circulation;Code;cohort;Collaborations;COVID-19 patient;Data;Development;Disease;DNA Binding;dust mite allergy;Enhancers;Epigenetic Process;experimental study;Exposure to;Extrinsic asthma;flu;follow-up;Follow-Up Studies;Frequencies;fungus;gain of function;genetic signature;genome-wide;genomic tools;Genomics;Grant;Health;Heterogeneity;House Dust Mite Allergens;Human;Hypersensitivity;Immune;Immune response;Immunology;improved;In Vitro;in vivo;Individual;Inflammation;Influenza;insight;Interferon Receptor;Interferons;knock-down;Knockout Mice;Ligands;loss of function;Lung;Maintenance;Modeling;Molecular;mouse model;Mus;novel;overexpression;Pathogenicity;Patients;Persons;Phenotype;Play;Population;prevent;Process;programs;Property;Proteins;Pyroglyphidae;receptor;Reporter;respiratory;respiratory virus;response;Response Elements;Role;Science;Signal Transduction;single cell ATAC-seq;single cell genomics;small hairpin RNA;Structure of parenchyma of lung;T-Cell Activation;T-cell diversity;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Th2 Cells;Therapeutic;Tissue Sample;TNF-related apoptosis-inducing ligand;TNFSF10 gene;tool;transcription factor;transcriptome;transcriptomics;Viral;Visit;Work

PROJECT_TITLE: Role of a Novel Interferon Responsive T Cell Subset in Allergy and Asthma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-A(03)]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_CITY: OMAHA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Puberty is a period marked by the emergence of enhanced cognitive functioning, but also an increased incidence of psychopathology. Some research has suggested that the drastic changes in sex hormones that occurs during the pubertal transition, namely dehydroepiandrosterone (DHEA), testosterone, and estradiol exert sex and region-specific effects on neural structure that affects cognitive and affective development, but research to date has been largely restricted to animals, with only a handful of human neuroimaging studies in this area. The proposed work will train a promising physician-scientist to use an advanced dynamic functional brain mapping method to identify the impact of developmental changes in DHEA, testosterone, and estradiol on brain and higher-order cognitive function in typically-developing children and adolescents.

PI_NAMEs: KILLANIN, ABRAHAM  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Academic achievement;Acceleration;Address;Adolescence;Adolescent;Affect;Affective;Age;age effect;Animals;Anxiety;Area;Attention;Behavior;Behavioral;boys;Brain;Brain Mapping;career;career development;Child;Childhood;Chronology;Clinical Skills;Cognition;Cognitive;cognitive development;cognitive enhancement;cognitive function;cognitive neuroscience;cognitive system;critical period;Data;dehydroepiandrosterone;Dendritic Spines;density;design;Development;Development Plans;Disease;Doctor of Philosophy;doctoral student;Emotional;Estradiol;Event;Fellowship;Female;frontier;Future;Goals;Gonadal Hormones;Gonadal Steroid Hormones;gray matter;Hair;Hormonal Change;Hormones;Hospitals;Human;improved;Incidence;Individual;Insula of Reil;International;Journals;Knowledge;Laboratories;Life;Link;Literature;Longitudinal Studies;Magnetic Resonance Imaging;Magnetoencephalography;male;Manuscripts;Maps;Measures;Medical center;memory process;Mental Depression;Mental disorders;Mentors;Methods;Minority;Nebraska;neural;neural circuit;neural network;neurodevelopment;neuroimaging;Neurophysiology - biologic function;Neurosecretory Systems;Parietal;Participant;Performance;Physicians;Plasma;Prevalence;programs;Proxy;Psychiatry;Psychopathology;Puberty;puberty transition;Reaction Time;reconstruction;Recording of previous events;Research;Research Design;Research Support;Rodent Model;Role;Sampling;Scientist;selective attention;sex;Sex Differences;Short-Term Memory;Socioeconomic Status;Source;statistics;Structure;symposium;Symptoms;Testing;Testosterone;Training;Universities;Visuospatial;Work;Youth

PROJECT_TITLE: The Effect of Pubertal Hormones on the Development of Neural Oscillatory Dynamics in Youth


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

ORG_CITY: ROCKVILLE

ORG_NAME: SIGMOVIR BIOSYSTEMS, INC.

PI_NAMEs: HAUSCHILD, STEVE  (contact)

PROJECT_TERMS: Contracts;Cotton Rats;Development;Evaluation;infectious disease model;Modeling;paramyxovirus vaccine;Therapeutic;therapeutic development;vaccine evaluation;Virus

PROJECT_TITLE: Task A88: Cotton Rat Model for the Evaluation of Vaccines and Therapeutics for RSV and Related Viruses


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: WILLS EYE HEALTH SYSTEM

ORG_STATE: PA

PHR: PROJECT NARRATIVE Glaucoma is a leading cause of blindness worldwide. However, all past research projects following the disease’s behavior over time have been marred by confounders such as administration of course-altering treatment or by using models which only partially reflect the glaucoma process. We will overcome these shortfalls by investigating glaucoma in non-human primates who naturally develop the disease by applying advanced ocular imaging methods to determine changes in the eye that will be directly related to the human eye.

PI_NAMEs: WOLLSTEIN, GADI  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age;Angiography;Animal Model;Animals;Anterior;Axon;Behavior;Biological;Biological Markers;Biology;Biomechanics;Blindness;Blood flow;Blood Vessels;Brain;Characteristics;Chronic Disease;Clinical;clinical diagnosis;Clinical Management;Clinical Research;cohort;Complex;Data;density;Development;Diagnosis;Diagnostic;Diastole;Disease;Disease Progression;Electroretinography;Exhibits;Experimental Animal Model;Eye;Fundus photography;Future;ganglion cell;Genetic;Glaucoma;health care availability;Homeostasis;Human;imaging modality;Impairment;improved;in vivo;in vivo Model;Individual;Inner Plexiform Layer;inter-individual variation;Interdisciplinary Study;Intracranial Pressure;Knowledge;Length;life span;Location;Longitudinal Studies;Macaca;Macaca mulatta;macula;Measurable;Measurement;microbiome;Modeling;Modification;Monitor;Natural History;nonhuman primate;ocular imaging;Open-Angle Glaucoma;Optic Disk;Optic Nerve;Optical Coherence Tomography;Papillary;Patients;Pharmaceutical Preparations;Physiologic Intraocular Pressure;Population;Porosity;Predisposition;Process;Property;Proteomics;Qualifying;rate of change;Research;Research Project Grants;Resources;response;Retina;retinal nerve fiber layer;Rodent Model;Severities;Severity of illness;Signal Transduction;Social Environment;spatial relationship;Structure;Suspect Glaucomas;Systole;Testing;Thinness;Time;Tissues;trait;translational potential;Visual impairment;Visual Pathways;Visual System

PROJECT_TITLE: Longitudinal Ocular Changes in Naturally Occurring Glaucoma Animal Model

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE Although current clinical evidence suggests that the potential benefits of tube feeding do not exceed considerable associated treatment burdens in older adults with advanced dementia, rates of tube feeding remain disproportionally high among Chinese-American older adults with advanced dementia. This proposed project will culturally adapt an existing decision aid intervention to improve decision-making about feeding options for Chinese-American dementia patients. If effective, this intervention will indicate the utility of decision aids as a methodology with broader applications to decision-making in end-of-life care in this population.

PI_NAMEs: PEI, YAOLIN  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: acceptability and feasibility;Address;advanced dementia;advanced directive;Aging;Alzheimer's disease related dementia;American;Area;Asia;Award;Behavior Therapy;Behavioral Research;Benefits and Risks;Caregivers;Caring;Characteristics;Chinese;Chinese American;Chinese population;Cities;Clinical;Clinical Trials Design;cognitive interview;Communities;community collaboration;community organizations;comparison group;Conflict (Psychology);Cultural Sensitivity;cultural values;Data;Decision Aid;Decision Making;Dementia;Dementia caregivers;Development;Disadvantaged;Eating;Education;Educational Materials;efficacy evaluation;efficacy testing;end of life;end of life care;end-of-life decision making;Ensure;Enteral Feeding;Environment;Equilibrium;Ethnic Origin;evidence base;Family;Family Caregiver;Family health status;Family member;family structure;feeding;Food;Fostering;Geriatrics;Goals;Grant;Hand;Health Benefit;Health Personnel;Health Professional;Heart;heuristics;High Prevalence;Hybrids;improved;Individual;Intervention;Intervention Studies;Interview;Knowledge;Language;Leadership;Linguistics;Literature;Mentors;Methodology;Mission;New York;New York City;Nurses;nutrition;Nutritional status;older adult;Outcome;Participant;Pathway interactions;Patient Preferences;Patients;Persons;Phase;Physicians;pilot test;Population;preference;Process;Professional Organizations;prototype;Qualitative Methods;Randomized, Controlled Trials;Reading;Recommendation;Research;research and development;Research Methodology;Research Personnel;research study;Research Support;Resources;Risk;Scientist;shared decision making;Signal Transduction;skills;Social Workers;Societies;Speech Therapist;success;support tools;surrogate decision making;Testing;therapy development;tool;Training;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: A culturally adapted decision aid intervention to support Chinese American dementia caregivers in feeding-related decisions

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: The gut immune system must maintain tolerance n the steady-state while retaining the ability to rapidly induce immunity to pathogens during infection. We have uncovered an intrinsic capacity of the gut to switch from tolerance to immunity and propose this is a physiologic response to infection and when inappropriately activated potentially contributes to intestinal inflammatory diseases.

PI_NAMEs: HSIEH, CHYI S;NEWBERRY, RODNEY D (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: adaptive immune response;Address;Antigen-Presenting Cells;Antigens;Autoantigens;Automobile Driving;Biological Assay;Cell Differentiation process;Cells;Chemicals;chronic inflammatory disease;Collection;cytokine;Development;Diet;dietary;Early identification;Ecosystem;enteric infection;Epithelial Cells;Epithelium;Equilibrium;Event;Exposure to;Flow Cytometry;Gastrointestinal tract structure;Gene Expression;Generations;Gnotobiotic;Goblet Cells;gut inflammation;Homeostasis;Immune;Immune response;Immune system;Immunity;Immunologics;in vivo;Infection;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Injury;insight;intestinal epithelium;Lamina Propria;Maps;Microbe;microbial;microbiota;microorganism antigen;Modeling;Monitor;Mucous body substance;Mus;novel strategies;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Phenotype;Physiological;Process;Property;Regulatory T-Lymphocyte;Reporter;response;Role;Severities;Small Intestinal Goblet Cell;Small Intestines;Specificity;Surface;T-cell receptor repertoire;T-Lymphocyte;transdifferentiation;Transgenic Mice

PROJECT_TITLE: Gut Intrinsic Inflammatory Responses


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: LOGAN

ORG_NAME: UTAH STATE UNIVERSITY

ORG_STATE: UT

PI_NAMEs: MORREY, JOHN  (contact)

PROJECT_TERMS: Anti-viral Agents;Contracts;Coxsackie Viruses;Development;Evaluation;Human poliovirus;infectious disease model;mouse model;therapeutic development

PROJECT_TITLE: Task A59: Mouse Model for Evaluating Antivirals Against Polio and Coxsackie Virus


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_NAME: WESTAT, INC.

PI_NAMEs: HERING, MARTHA  (contact)

PROJECT_TERMS: Amendment;Authorization documentation;Awareness;Budgets;Cancer Therapy Evaluation Program;Cancer Trials Support Unit;Clinical Data;Clinical Research;Collaborations;Computerized Medical Record;Contractor;Contracts;Custom;Data;Data Management Resources;data quality;Data Security;Development;Disasters;Education;electronic medical record system;Federal Government;Good Clinical Practice;Government;Government regulations;Guidelines;Health;Human;improved;Informatics;Information Services;Institution;International;Life Cycle Stages;Malignant Neoplasms;Modeling;Modernization;Monitor;Monitoring Clinical Trials;Oncology;operation;Patients;Performance;Persons;Pharmaceutical Preparations;Phase;Procedures;Process;programs;Protocols documentation;Quality Control;Records;Recovery;Reporting;Secure;Services;Site;Support System;System;tool;Training;United States Dept. of Health and Human Services;Update;web site;Work;working group

PROJECT_TITLE: CANCER TRIALS SUPPORT UNIT  (CTSU) CORE SUPPORT SERVICES & THE CTSU ENTERPRISE OF SYSTEMS


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS

ORG_CITY: RESTON

ORG_NAME: EDJ ASSOCIATES, INC.

ORG_STATE: VA

PI_NAMEs: REED, CRYSTAL  (contact)

PROJECT_TERMS: American Association of Cancer Research;American Society of Clinical Oncology;Awareness;base;Cancer Trials Support Unit;Certification;Consent Forms;Consultations;Contractor;Contracts;Education;Ensure;Government;improved;Language;meetings;Oncology;Procedures;programs;Protocols documentation;Recommendation;Reporting;Risk;Role;Secure;Site;Spanish/English;Standardization;Summary Reports;symposium;Training;Training and Education;Translations;usability;Work

PROJECT_TITLE: AWARENESS, EDUCATION, AND TRAINING: CANCER TRIALS SUPPORT UNIT (CTSU)


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Patient Safety

PI_NAMEs: PATRICHUK, LUCILLE  (contact)

PROJECT_TERMS: Authorization documentation;Awareness;Budgets;Cancer Therapy Evaluation Program;Cancer Trials Support Unit;Clinical Data;Clinical Research;Collaborations;Contractor;Contracts;Custom;Data;Data Management Resources;data quality;Data Security;Development;Disasters;Education;Federal Government;Good Clinical Practice;Government;Government regulations;Guidelines;Health;Human;improved;Informatics;Information Services;Institution;International;Life Cycle Stages;Malignant Neoplasms;Modeling;Modernization;Monitor;operation;Patients;Performance;Persons;Phase;Procedures;Process;Protocols documentation;Records;Recovery;Reporting;Secure;Services;Site;Support System;System;tool;Training;United States Dept. of Health and Human Services;Update;web site;Work;working group

PROJECT_TITLE: TASK ORDER 4A SITE STUDY SETUP: CTSU IDIQ


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: FAIRFAX

ORG_NAME: GEORGE MASON UNIVERSITY

PHR: NARRATIVE Venezuelan equine encephalitic virus (VEEV) infects humans and can cause inflammation, acute degenerative neuronal changes, behavioral changes, memory loss and seizures, with severe cases resulting in death, but there are no therapeutics available to treat this disease. The capsid protein of VEEV is able to suppress antiviral responses, thereby making it an attractive therapeutic target. We aim to develop more potent and safe second generation inhibitors that will interfere with VEEV capsid-host protein interactions preventing VEEV induced diseases.

PI_NAMEs: KEHN-HALL, KYLENE ;KLIMOV, DMITRI KONSTANTINOVICH;PAIGE, MIKELL  (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Acute;alpha Karyopherins;Animals;Anti-viral Agents;Anti-viral Response;antiviral drug development;Attenuated Vaccines;Behavioral;Binding;Binding Sites;Biochemical;Biological Assay;Biological Availability;blood-brain barrier permeabilization;Caco-2 Cells;Calorimetry;Capsid;Capsid Proteins;Category B pathogen;Cell Nucleus;Cells;Cessation of life;Chemical Structure;Classification;Clinical;Complex;computer studies;Confocal Microscopy;cytotoxicity;Data;Decision Making;design;Disease;dosage;efficacy study;Free Energy;Frequencies;Generations;Genetic Transcription;Half-Life;Herpesvirus 1;Human;Hybrids;improved;in silico;In Vitro;in vivo;indexing;Inflammation;inhibitor;Knowledge;Laboratory Personnel;Lead;Libraries;Liver Microsomes;Maps;Measures;Memory Loss;microscopic imaging;Military Personnel;Modification;Molecular;molecular dynamics;mouse model;Mutation;National Institute of Allergy and Infectious Disease;Neurons;next generation;novel;novel therapeutics;Nuclear;Pathology;Patients;Permeability;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;prevent;protein aminoacid sequence;protein protein interaction;Proteins;Resistance development;Risk;Seizures;Series;side effect;simulation;small molecule;small molecule inhibitor;solute;Structure-Activity Relationship;Symptoms;Testing;Therapeutic;therapeutic target;Titrations;Toxic effect;trafficking;Venezuelan Equine Encephalitis Virus;Viral;Viral Load result;Viral Pathogenesis;Virulence;Virus Diseases;Virus Replication;water solubility;Western Equine Encephalitis Virus

PROJECT_TITLE: Developing capsid-importin alpha inhibitors for the treatment of VEEV infection

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Genetic Testing;Genetics;Health Services;Human Genome;Prevention;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Lynch syndrome (LS) affects over a million of people in the United States and is one of the leading causes of hereditary cancers (e.g., colorectal and endometrial cancer), which can be prevented or treated with active screening and early diagnosis. Cascade testing for at-risk relatives of patients with LS is cost-effective, but underutilized because there are many barriers to testing. Increasing pre-test genetic counseling in this population will have substantial public health impact by promoting awareness and identification of LS and subsequently help reduce cancer morbidity and mortality.

PI_NAMEs: YAN, HAOYANG  (contact)

PROGRAM_OFFICER_NAME: EVERSON, NICOLE MARIE

PROJECT_TERMS: Address;Adherence;Affect;anti-cancer research;Appointment;Area;arm;Attitude;Awareness;barrier to testing;Behavior;behavior change;behavior change wheel;Behavior Therapy;Behavioral;Behavioral Medicine;Blood;Cancer Control;cancer predisposition;cancer risk;career;career development;cascade genetic testing;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;Colonoscopy;Colorectal Cancer;Conduct Clinical Trials;Consensus;cost effective;Counseling;Data;Decision Making;design;Development;Development Plans;Diagnosis;Distress;Drops;Early Diagnosis;efficacy testing;Endometrial Carcinoma;Ensure;Exercise;Family;feasibility trial;Focus Groups;Fright;Future;gene repair;General Population;Genetic Counseling;genetic counselor;Genetic Risk;genetic testing;Genomics;Grant;Hereditary Malignant Neoplasm;Hereditary Nonpolyposis Colorectal Neoplasms;improved;Individual;Inherited;Insurance;Intervention;Interview;Knowledge;lifetime risk;Malignant Neoplasms;Medical;medical schools;men;Mentors;Methodology;Methods;Mismatch Repair;Morbidity - disease rate;mortality;motivated behavior;National Cancer Institute;Pamphlets;Participant;Pathogenicity;Patients;Persons;pilot trial;Population;Population Genetics;Positioning Attribute;prevent;Prevention;proband;Protocols documentation;prototype;Public Health;Publishing;Qualitative Methods;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Relative Risks;Research;Research Activity;Research Personnel;Resources;Risk;Scientific Advances and Accomplishments;Scientist;screening;Social Sciences;Structure;supportive environment;Syndrome;Techniques;Testing;testing uptake;theories;therapy design;therapy development;Training;treatment arm;Treatment Efficacy;trial design;United States;Universities;uptake;usability;usual care arm;Variant;Woman;Writing

PROJECT_TITLE: Development and Initial Testing of a Behavioral Intervention to Increase Pre-Test Genetic Counseling Among Families at Risk of Lynch Syndrome


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer;Genetics;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project narrative Epigenetic dysregulation is frequently observed in the disease pathology of pediatric cancers, including neuroblastoma (NB), the most common extracranial solid tumor in pediatric patients. We’ve discovered that adoption of a mesenchymal lineage is associated with loss of GD2 expression, resulting in resistance to anti- GD2 therapy. This proposal outlines the targeting of PRC1.1 via inhibition of USP7 as a therapeutic intervention to directly target neuroblastomas and restore the response to anti-GD2 therapy. .

PI_NAMEs: MABE, NATHANIEL  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Adoption;Adrenergic Agents;Advisory Committees;Antigens;Cell Differentiation process;Cell Line;Cell Maintenance;Cell surface;Cells;Cephalic;Chemistry;Chemoresistance;Chromatin;combinatorial;Committee Members;Complex;Credentialing;CRISPR screen;Dependence;design;Development;Disease;Down-Regulation;early childhood;Enhancers;Enzymes;Epigenetic Process;EZH2 gene;Gangliosides;Gatekeeping;Gene Expression;Genes;Genetic;Genetic Transcription;Glycolipids;Goals;Heterogeneity;high risk;Immunooncology;Immunotherapy;In Vitro;in vivo;Individual;inhibitor;Intervention;Knock-out;Knowledge;Link;loss of function;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Mediating;member;Mesenchymal;Mining;Modeling;nerve stem cell;Neural Crest;Neuroblastoma;neuroblastoma cell;Neuronal Differentiation;novel strategies;Pathology;Pathway interactions;Patients;pediatric patients;pharmacologic;Pharmacology;Polycomb;Postdoctoral Fellow;PRC1 Protein;prevent;programs;Protein Subunits;Proteins;Refractory;Regulation;Repression;Resistance;resistance mechanism;response;Role;single cell sequencing;single-cell RNA sequencing;small molecule inhibitor;Solid Neoplasm;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapy resistant;Tissues;Training;transcription factor;Tretinoin;tumor;Variant;Work

PROJECT_TITLE: Defining PRC1.1 as a gatekeeper of lineage plasticity and response to anti-GD2 therapy

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


FUNDING_MECHANISM: OTHERS

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PI_NAMEs: MALIK, HARMIT S. (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Acceleration;Advocate;Affect;Architecture;Blood;cancer genomics;cancer heterogeneity;Cancer Patient;cancer type;Cells;Chemicals;Chemistry;Chromosome Pairing;Chromosomes;Collaborations;combinatorial;Communities;computer scientist;Data;Diagnostic;DNA;Drug resistance;Drug Targeting;Early Diagnosis;Education;epigenomics;Evolution;experience;extrachromosomal DNA;Family;Fingerprint;Fostering;Funding Mechanisms;Gene Expression Regulation;Gene Order;Generations;Genes;Genetic;Genetic Transcription;Genome;genome sequencing;Human;Immune Evasion;Immune system;Immunobiology;Immunologics;Immunology;Immunotherapy;Infrastructure;innovation;insight;International;Licensing;Ligands;live cell imaging;machine learning algorithm;Maintenance;Malignant Neoplasms;mathematical model;Medicine;Modeling;Monitor;multiple omics;Mutation;novel;Nucleic Acids;Oncogenes;Patients;Pharmaceutical Preparations;prevent;Process;Productivity;programs;Research Personnel;Resources;Role;Therapeutic;time use;Tissues;tool;tumor;tumor growth;Tumor Promotion;whole genome;Work;yeast genetics;Yeast Model System

PROJECT_TITLE: eDyNAmiC - FREDHUTCH


ORG_CITY: BERLIN

ORG_COUNTRY: GERMANY

ORG_FIPS: GM

ORG_NAME: CHARITE, UNIVERSITAETSMEDIZIN BERLIN

PI_NAMEs: HENSSEN, ANTON GEORGE (contact)

PROJECT_TITLE: eDyNAmiC - CHARITE


ORG_CITY: LONDON

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIV/LONDON-QUEEN MARY& WESTFIELD COLL

ORG_ZIPCODE: E1 4NS

PI_NAMEs: HUANG, WEINI  (contact)

PROJECT_TITLE: eDyNAmiC-QMUL


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Childhood Leukemia;Gene Therapy;Genetics;Hematology;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: No Text

PI_NAMEs: MARIS, JOHN M (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Address;Adult;Agreement;Antigens;Area;Autologous;B-Cell Acute Lymphoblastic Leukemia;B-Lymphocytes;Back;bench to bedside;Biological;Brain Neoplasms;cancer cell;Cancer Patient;Cancer Relapse;cancer type;CAR T cell therapy;Cell Physiology;Cell Therapy;cellular engineering;Characteristics;chemotherapy;Child;Childhood;Childhood Cancer Treatment;Childhood Leukemia;childhood sarcoma;Childhood Solid Neoplasm;chimeric antigen receptor;chimeric antigen receptor T cells;Clinic;Clinical;clinical development;Clinical Research;clinical translation;Clinical Trials;Communities;comorbidity;Complex;Coupled;Coupling;Custom;Cytometry;Data;Data Collection;data complexity;data integration;data sharing;Databases;design;Development;diffuse midline glioma;Disease;engineered T cells;Engineering;Generations;Genetic Engineering;Heart;Hematologic Neoplasms;high risk;Immune;immune checkpoint blockade;Immune Evasion;Immunosuppression;Immunotherapy;improved;in vivo;in vivo Model;Knowledge;Learning;Life;Malignant Childhood Neoplasm;Malignant lymphoid neoplasm;Malignant Neoplasms;manufacture;Mass Spectrum Analysis;Methods;Modeling;Mutation;neoplastic cell;Neuroblastoma;next generation;novel;Operative Surgical Procedures;Patients;Pediatric Neoplasm;Pediatric Oncology;phase I trial;Plasma Cells;pre-clinical;Pre-Clinical Model;preclinical development;Primary Neoplasm;Program Development;programs;Protein Engineering;Radiation;receptor;Refractory;Relapse;Research Design;Research Personnel;Resistance;response;Route;sharing platform;small molecule;Solid;Solid Neoplasm;standard of care;Structure;Surface Antigens;Survival Rate;Survivors;System;T cell therapy;T-Lymphocyte;Technology;Testing;Text;Therapeutic;Toxic effect;Translating;tumor;tumor heterogeneity;tumor microenvironment;Vision;Work;Xenograft procedure

PROJECT_TITLE: NextGen - CHOP


ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PI_NAMEs: CAAN, BETTE J (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Address;Adipose tissue;Affect;Algorithmic Analysis;Animals;Anorexia;anorexic;anti-cancer treatment;Atlases;Atrophic;Autophagocytosis;Basic Science;Behavior;behavioral study;Biological Markers;Blood;Body Composition;Body Weight decreased;Cachexia;Cancer Cachexia;Cancer Model;Cancer Patient;cancer therapy;carcinogenesis;Catabolic Process;Cells;Characteristics;chemotherapy;Classification;Clinic;Clinical;clinical biomarkers;clinical care;clinical phenotype;Clinical Research;clinical subtypes;Clinical Trials;clinically relevant;Cluster Analysis;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Combined Modality Therapy;cytokine;Cytometry;Data;Desire for food;Diagnosis;dietary;Eating;effective therapy;Endocrine;Energy Metabolism;Epidemiology;Etiology;Fatty acid glycerol esters;Feeding behaviors;Foundations;Future;GDF15 gene;Gene Expression Profiling;Generations;Genes;Genetic;Geography;Goals;gut microbiome;high risk;Histologic;Hormonal;Hormones;host neoplasm interaction;Human;Image;imaging Segmentation;Immune;Immunology;improved;improved outcome;in vivo;Inflammatory;Inflammatory Response;innovation;insulin signaling;Interleukin-6;International;Intervention;Intrinsic factor;Investigation;Isotopes;Lead;Life Expectancy;Link;Lipolysis;lung microbiome;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measures;Mediator;Medical;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic phenotype;Metabolism;Methods;microbial;microbiome;microbiota;molecular subtypes;mortality;mouse model;multicatalytic endopeptidase complex;multidisciplinary;Mus;Muscle;neoplastic cell;Neuroendocrinology;Neurologic;Neurosecretory Systems;Non-Small-Cell Lung Carcinoma;novel;nuclear imaging;Nutrient;Observational Study;optogenetics;Organ;Organoids;Pathway interactions;patient population;Patient Recruitments;Patient-Focused Outcomes;Patients;Performance Status;Peripheral;pharmacologic;Phenotype;Physical Function;Physiological;Pre-Clinical Model;Prospective, cohort study;Quality of life;Recovery;recruit;response;Risk;Science;Scientist;Skeletal Muscle;Specialist;System;Therapeutic;Time;Tissues;tool;Toxin;Translations;treatment response;treatment strategy;treatment trial;tumor;tumor metabolism;tumor microenvironment;Ubiquitin;uptake;Validation;virtual;Vision;wasting;Wasting Syndrome;Whole Organism;Work;Xenograft procedure

PROJECT_TITLE: CANCAN - Kaiser


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE A substantial proportion of the growing elderly population have Alzheimer's disease or related dementias (ADRD), and their progressive daily challenges to meeting essential needs (e.g., managing finances, medication, transportation) are exacerbated when they live alone and thus lack cohabitants who can compensate for the cognitive impairment, leading to emergent problems including untreated medical conditions, self-neglect, malnutrition, falls, and fires. To help address this large and growing problem, the proposed research will elucidate key barriers and facilitators to accessing and using long-term services and supports (LTSS) for older adults with ADRD, especially those who live alone and racial/ethnic minorities. The results of this study will support policies to increase access, affordability, acceptance, and use of essential LTSS for these vulnerable populations. 1

PI_NAMEs: PORTACOLONE, ELENA  (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Address;Administrator;Adult Children;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;Asian population;Black Populations;Child;Cognition;cohort;Communities;community advisory board;Compensation;Consultations;cost;Data;design;Development;development policy;Distress;Education;Elderly;Ensure;ethnic minority;Ethnic Origin;Ethnic Population;falls;Family;Family member;family support;Fire - disasters;Friends;Future;Health;Health and Retirement Study;health disparity;Health Services Accessibility;Heterogeneity;high risk;Home Health Aides;Hospitalization;human old age (65+);Impaired cognition;Individual;informant;Institutionalization;Interview;Knowledge;Latino Population;Link;Lived experience;Living Arrangement;Malnutrition;Medicaid;Medical;meetings;Methods;Modeling;older adult;Older Population;Outcome;participant observation;Performance;Personal Satisfaction;Persons;Pharmaceutical Preparations;Policies;policy recommendation;Population;Positioning Attribute;Provider;Public Health;Race;racial minority;racial population;Reduce health disparities;Reporting;Research;Rural;self neglect;Services;Social Workers;Spouses;Structure;Transportation;United States;urban residence;Vulnerable Populations

PROJECT_TITLE: Access and use of long-term services and supports for older adults living alone with Alzheimer's disease and related dementias from four racial/ethnic groups

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Families are a key social determinant of the health and well-being of older adults, potentially creating or expanding inequities in how well care needs are met. Disadvantage may be especially heightened among older adults with ADRD who may be more likely to live in complex families. This project seeks to enhance measurement of family and kinship ties and caregiving norms and behaviors regarding care for older adults in order to better understand under what circumstances complex family and kinship ties become activated and how this process differs for individuals living with ADRD.

PI_NAMEs: PATTERSON, SARAH ELIZABETH (contact)

PROJECT_TERMS: Address;Age;Aging;Agreement;Alzheimer's disease related dementia;American;Behavior;Biological;care recipients;Caregivers;caregiving;Caring;cognitive testing;Complex;Contracts;Data;dementia caregiving;design;disability;Disadvantaged;ethnic minority;expectation;experience;Family;Family Caregiver;family caregiving;Family Demographies;Family member;Focus Groups;Friends;Grant;Health;high risk;Hour;Individual;Inequality;Inequity;innovation;Internet;Knowledge;Language;Legal;Literature;Measurement;Measures;member;Mentors;novel strategies;Nuclear;older adult;Personal Satisfaction;Phase;Population;population based;Positioning Attribute;Process;progressive care;racial minority;Research Activity;Research Personnel;Resources;Review Literature;Risk;Role;skills;social health determinants;Stepfamilies;Survey Methodology;Surveys;Testing;Training;Training Activity;United States National Institutes of Health

PROJECT_TITLE: Caregiving, Complex Family and Kinship Ties, and Alzheimer's Disease and Related Dementias (ADRD)

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative – Overall  Defining bone marrow cell identities and states using quantitative spatial maps of RNA, protein, and N- glycans, our proposed Bone Marrow Tissue Mapping Center will dissect the cellular composition and spatial structure of bone marrow niches to understand which cells and interactions are critical to each branch of hematopoietic maturation. The multi-arm sample collection strategy, leveraging of clinically-validated pre- analytical pipelines, assay technologies (Nanostring DSP, Multiplexed Ion Beam Imaging, and MALDI-MSI), computational tools (pixel-based analyses, cell-based analyses, neighborhood analyses), and biological principles are broadly applicable to and complement other HuBMAP projects. Interrogating the interdependence between bone marrow tissue structure and hematopoiesis is informative not just in blood cell maturation, but for understanding metabolism, aging, and development of cellular therapies.

PI_NAMEs: ANGELO, ROBERT MICHAEL;BENDALL, SEAN CURTIS (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Affect;Age;age related changes;Aging;Anatomy;Antibodies;antimicrobial;Archives;arm;Atlases;Biological;Biological Assay;Blood Cells;Blood Group Antigens;Board Certification;bone;Bone Marrow;Bone Marrow Cells;Bone structure;Cell Maturation;Cell Therapy;Cells;cellular development;Clinical;cohort;Collection;Communities;Complement;computerized tools;Data;Data Analyses;data analysis pipeline;data pipeline;Data Set;demographics;Diagnosis;Diameter;DNA;Doctor of Philosophy;Ensure;Erythroid;ethnic diversity;femur head;Future;Gender;Genetic Transcription;glycosylation;Goals;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hemostatic function;hip replacement arthroplasty;Histologic;Human;Human BioMolecular Atlas Program;human tissue;Image;imaging modality;Imaging technology;Length;Maps;Marrow;mass spectrometric imaging;meetings;Metabolism;Modality;Morphology;multimodality;multiplexed imaging;Multiplexed Ion Beam Imaging;multiscale data;nano-string;Neighborhoods;novel;Nutritional;Oligonucleotides;Oxygen;Pathologist;Pathology;Patients;Phenotype;Physiologic calcification;Polysaccharides;Population;preservation;Process;Production;progenitor;programs;prospective;Proteins;Protocols documentation;Quality Control;quantitative imaging;Race;Reporter;Research Personnel;rib bone structure;RNA;sample collection;Sampling;Site;Skeleton;Source;Spatial Distribution;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;spine bone structure;Standardization;Sternum;Stromal Cells;Structure;Technology;Tissue Banks;Tissue imaging;tissue mapping;Tissues;tool;transcriptomics;Variant;Vision;Work

PROJECT_TITLE: Multimodal histologic atlas of human bone marrow


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PI_NAMEs: FERNANDEZ-SESMA, ANA  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Accountability;Address;Argentina;Articulation;Collaborations;Communication;Data;data sharing;Decision Making;Dengue;design;direct application;Doctor of Philosophy;Ensure;Environment;experimental study;flexibility;Funding Opportunities;Future;Goals;Human;Immune response;Immunity;Immunology;Infection;Infrastructure;Institution;Laboratories;lectures;Manuscripts;medical schools;meetings;member;Microbiology;Monitor;National Institute of Allergy and Infectious Disease;New York;organizational structure;Performance;Phenotype;Policies;Preparation;Principal Investigator;programs;Progress Reports;Readiness;Reagent;Recommendation;Reporting;Research;Research Activity;Research Personnel;Resource Allocation;Resources;Role;Sampling;Services;Strategic Planning;symposium;Time;United States National Institutes of Health;Vaccination;Viral

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROGRAM NARRATIVE This training program is specifically designed to train a new cadre of researchers and leaders to address major but as yet under-studied public health problems engendered by conditions prevalent in urban and rural informal human settlements (slums) of low and middle-income countries (LMIC). This training is relevant also to developed countries as informal settlements in the form of homeless encampments expand. Selected candidates will undergo field training on site in LMICs to develop new global health research skills framed within our project research theme of health equity.

PI_NAMEs: BARRY, MICHELE ;HARRIS, EVA ;KO, ALBERT ICKSANG (contact);MADHIVANAN, PURNIMA

PROGRAM_OFFICER_NAME: KATZ, FLORA N

PROJECT_TERMS: Address;Africa;Arizona;Asia;California;career;Career Choice;career development;Caribbean region;Central America;Collaborations;Communities;Country;Dedications;design;Discipline;Disease;doctoral student;Eastern Europe;Educational workshop;Environmental Health;Exposure to;Faculty;faculty mentor;global health;Health;health equity;Health equity research;HIV;Human;Inequity;Injury;Institution;Interpersonal Violence;low and middle-income countries;member;Mental Health;Mentors;Mentorship;Methods;multidisciplinary;National Institute of Environmental Health Sciences;Persons;Postdoctoral Fellow;pre-doctoral;programs;recruit;Research;Research Methodology;Research Personnel;Research Support;Research Training;Rural;Scholars Program;Site;Slum;South America;Substance abuse problem;Supervision;Time;Training;Training Programs;Universities;Vulnerable Populations;Women's Health;Work

PROJECT_TITLE: GHES - NIEHS - Anafo


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MADISON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Metalloenzymes are ubiquitous throughout biology, comprising approximately half of all known enzymes, yet their biogenesis and active site maturation is often unclear due to complicated mechanisms of assembly. Metallocofactor assembly in Photosystem II provides a convenient model system for structural and biochemical studies due to its light dependence and recent advances in controlling its step-wise assembly. Because metalloenzymes are implicated in a variety of human diseases, gaining a fundamental understanding of their biogenesis and metallocofactor assembly may lead to improved therapeutics and synthetic metalloenzyme design principles.

PI_NAMEs: GISRIEL, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Photosystem II as a model protein for understanding metalloenzyme active site assembly


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: HOUSTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

PHR: In many types of cancer, cancer cells from the primary tumor can intravasate into the peripheral circulation as circulating tumor cells (CTCs). Cancer cells respond to the forces in blood flow in ways that are not yet fully understood. This project will develop new technology to facilitate new understanding of the response of cancer cells to fluid flow.

PI_NAMEs: KING, MICHAEL R. (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: Apoptosis;Area;Attention;Behavior;Biochemical;Biological;biological adaptation to stress;Blood;Blood Cells;Blood Circulation;Blood flow;Blood specimen;Calcium;cancer cell;Cancer Patient;cancer type;Cardiac;Cell Aggregation;Cell Death;Cell Line;Cell model;Cell Separation;Cell Survival;Cells;Chemoresistance;Circulation;Clinical;Coculture Techniques;CRISPR/Cas technology;demographics;Development;Devices;Disease;Environment;Epithelium;experimental study;Fibroblasts;Flow Cytometry;fluid flow;Gene Expression;Genes;Genotype;Goals;in vitro testing;in vivo;Induction of Apoptosis;Injections;knock-down;Laboratories;Ligands;Liquid substance;Macrophage;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Measures;mechanical signal;mechanical stimulus;Mechanics;mechanotransduction;Membrane;Mesenchymal;Metastatic Prostate Cancer;Mitochondria;model development;Modeling;Morphology;mouse model;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;new technology;Peripheral;Phenotype;Physiologic pulse;Piezo 1 ion channel;Play;Population;Primary Neoplasm;Process;Production;prostate cancer cell;prostate cancer cell line;Protocols documentation;Research;response;Role;shear stress;Signal Transduction;Site;Solid Neoplasm;Spectrophotometry;spheroids;Stromal Cells;Suspensions;Technology;TNF gene;trait;transcriptome sequencing;Translating;Tumor Burden;tumor progression;Tumor-associated macrophages;Work

PROJECT_TITLE: Enabling Technology to Study Mechanosensitive and Mechanoresistant Cancer Cells in Flow

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_NAME: WASHINGTON UNIVERSITY

PI_NAMEs: GURNETT, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Acceleration;Affect;Ally;antagonist;Award;Behavior;Behavioral;Biological Models;biomarker development;Brain;brain circuitry;Child Abuse;Childhood;Clinical;Clinical Data;Clinical Research;clinical translation;Clinical Trials;Clinical Trials Unit;Complement;Core Facility;cost;Data;data acquisition;Dedications;design;Development;Disability prevention;Disability research;Disease;early detection biomarkers;Early identification;Electrophysiology (science);Faculty;Family;follow-up;Fragile X Syndrome;Funding;Genes;Genetic;Genetic Counseling;Genome;genomic data;Genomics;Genotype;health determinants;Human;human subject;Impairment;Individual;Infant Development;Informatics;Infrastructure;innovation;Institution;Institutional support resources;Insurance;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Intervention;Intervention Trial;Investments;K-Series Research Career Programs;Laboratories;Link;Medical;medical schools;Natural History;Near-Infrared Spectroscopy;Neurodevelopmental Disorder;neuroimaging;neuropsychiatry;novel strategies;Outcome;Pathogenesis;Pathogenicity;Patient observation;Patient Participation;patient population;Patient Recruitments;Patients;personalized intervention;Phenotype;Physicians;Populations at Risk;premature;prevent;Prevention;programs;psychosocial;Research;Research Personnel;Research Support;Resources;Risk;Role;Science;scientific hub;Secure;Services;Site;social;Structure;Syndrome;Technology;Testing;Therapeutic;Training;translational applications;Universities;Variant;visual tracking;Washington

PROJECT_TITLE: Clinical Translational Core


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PI_NAMEs: HEDGES, JERRIS ROBERT (contact)

PROGRAM_OFFICER_NAME: WONNUM, SUNDANIA J W


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Microbiome;Nutrition

ORG_CITY: Boston

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: TUFTS UNIVERSITY MEDFORD

ORG_STATE: MA

PHR: Project Narrative To characterize the intestinal microbiota populating different sites of the gastrointestinal tract, we propose to develop an ingestible device termed “micro-pill”. The 3D-printed micro-pill will be fitted with pH and oxygen sensors such that it can sample autonomously from pre-determined intestinal sites after ingestion. Given the importance of the intestinal microflora to health and disease, the ability to non-invasively sample intestinal microbial populations throughout the GI tract will facilitate the development of precision nutritional prescriptions aimed at optimizing long-term health outcomes.

PI_NAMEs: SONKUSALE, SAMEER R (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TITLE: Ingestible Pill for spatially targeted sampling of gut microbiome


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Data Science

ORG_CITY: CAMBRIDGE

ORG_NAME: VIVLI, INC.

PI_NAMEs: LI, REBECCA H (contact)

PROJECT_TERMS: Adopted;Architecture;Awareness;Clinical Trials;collaborative approach;Data;data ecosystem;data management;data resource;data reuse;Data Science;data sharing;data submission;Ecosystem;FAIR principles;Funding;generalist repository;Infrastructure;Mission;Modernization;Reporting;Research Personnel;Services;social;Strategic Planning;Training;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: Vivli: A Generalist Repository For Clinical Trials Data


NIH_SPENDING_CATS: Osteoporosis

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: NARRATIVE: Maintenance of life-long skeletal integrity requires bone to be continuously remodeled by osteoclasts that erode old bone and osteoblasts that deposit new bone, and many human bone diseases are caused by excessive osteoclasts eroding to much bone, weakening the skeleton (e.g., osteoporosis, fibrous dysplasia). We will resolve how a novel regulator controls osteoclast formation/function and characterize how disrupted osteoclast-osteoblast signaling promotes the progression of an osteoclast-based bone disease. Our project will fill fundamental gaps in the understanding of how osteoclasts form and remodel bone and identify novel therapeutic strategies for the targeted treatment of human bone disease.

PI_NAMEs: WHITLOCK, JARRED MARCUS (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Address;Albers-Schonberg disease;ANXA5 gene;Back;Binding;Biological;Biological Assay;Biological Process;bone;Bone Development;Bone Diseases;bone loss;Bone remodeling;Bone Resorption;career development;Cell membrane;Cell Nucleus;Cells;Childhood;Data;Degradation Pathway;Deposition;Development;Disease;Disease Progression;Eukaryotic Cell;Event;Excision;experience;Feedback;Fibrous Dysplasia;Goals;Health;Human;Human Development;in vivo;in vivo Model;Individual;infancy;Laboratories;Lesion;Link;Lupus;Machine Learning;Maintenance;Membrane;Membrane Fusion;Membrane Proteins;Mentorship;Mission;Modeling;Molecular;Monitor;mouse model;National Institute of Child Health and Human Development;new therapeutic target;novel;novel marker;novel therapeutic intervention;Osteoblasts;Osteoclasts;Osteolytic;Osteoporosis;Paget's Disease;Pathway interactions;Peptide Library;Peptides;Phosphatidylserines;prevent;Process;Proliferating;protein degradation;protein expression;protein structure;protein transport;Proteins;Research;Research Personnel;Rheumatoid Arthritis;RNA;RNA metabolism;Role;screening;Signal Transduction;skeletal;Skeleton;Study models;Surface;targeted treatment;Tertiary Protein Structure;Testing;Time;trafficking;Training;treatment strategy;Work

PROJECT_TITLE: Resolving the mechanism of osteoclast multinucleation and signaling in bone remodeling


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Endometriosis;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pain Research;Precision Medicine;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: NARRATIVE Endometriosis is a common but poorly understood condition, particularly in non-Whites, that is non-malignant but often harbors mutations in “driver” genes. This Study will use state-of-the-art single cell transcriptomics, epigenomics, exome-sequencing and a bioluminescent transplant model to catalogue somatic mutations across a diverse cohort of patients and dissect consequences of somatic mutations to identify new therapeutic opportunities. These insights are expected to pave the way to the development of precision medicine for endometriosis.

PI_NAMEs: ANGLESIO, MICHAEL STEPHEN;LAWRENSON, KATE  (contact)

PROGRAM_OFFICER_NAME: ALLEN, CATHERINE LEIGH

PROJECT_TERMS: Address;Affect;African American population;Age;Alleles;Animal Model;Anxiety;ARID1A gene;Asian;Asian population;Asian Women;black women;Catalogs;Cell Communication;Cell Compartmentation;cell type;Cells;central pain;Chronic;Chronic Disease;chronic pain;clinical care;cohort;comorbidity;Data;Development;Diagnosis;Disease;driver mutation;Dysmenorrhea;endometriosis;epigenomics;Epithelial Cells;Epithelium;ethnic diversity;European ancestry;eutopic endometrium;exome sequencing;experience;Fatigue;Female infertility;Financial Hardship;follow-up;Frequencies;functional genomics;gastrointestinal;Genes;Genetic;Genomics;Goals;Gynecologic;Health Services Accessibility;Hemorrhage;Heterogeneity;Hispanic Populations;Hispanic Women;Hormone Responsive;Immune;in vivo;Individual;individualized medicine;Infertility;Inflammatory;innovation;insight;intercellular communication;Invaded;KRAS2 gene;Lesion;Life;Ligands;Lymphatic Endothelial Cells;Maps;Mental Depression;Metabolic;Methodology;Modeling;Modification;Molecular;Molecular Profiling;Monitor;mouse model;mutant;Mutation;Non-Malignant;novel;novel therapeutics;Pain;paracrine;Pathogenesis;Pathway interactions;Patients;personalized medicine;PIK3CA gene;Population;Population Heterogeneity;precision medicine;Prevalence;programs;PTEN gene;Questionnaires;racial difference;racial diversity;reproductive;Resources;Role;sample collection;Sampling;Signal Transduction;single cell genomics;Site;Somatic Mutation;Standardization;Symptoms;Syndrome;targeted sequencing;Technology;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic target;Therapeutically Targetable;Tissues;transcriptomics;Translating;transplant model;Transplantation;Uterus;White Women;Woman

PROJECT_TITLE: Functional Genomics Across an Ethnically and Racially Diverse Endometriosis Population

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE FOR LAY AUDIENCE Ovarian cancer is responsible for more than 150,000 deaths per year and so it remains a high priority to develop effective prevention approaches and to identify new disease specific therapies to reduce disease mortality. The research we propose here has two components: (1) To characterize the component of genetic and epigenomic interactions in ovarian cancer development; (2) to establish the functional relevance of genetic findings for clinical translation. This is a highly integrated multi-disciplinary research program – but these approaches to novel discovery and functional understanding are desperately needed to advance our basic knowledge of this disease to develop clinical interventions that save lives.

PI_NAMEs: GAYTHER, SIMON ANDREW (contact);GUSEV, ALEXANDER

PROGRAM_OFFICER_NAME: NELSON, STEFANIE A

PROJECT_TERMS: Address;Automobile Driving;Binding Sites;Biological Assay;BRCA1 gene;Cancer Biology;cancer initiation;cancer predisposition;cancer risk;Candidate Disease Gene;candidate identification;candidate validation;Cell Physiology;Cells;Cessation of life;Chemoresistance;ChIP-seq;chromosome conformation capture;Chromosomes;Clinical;clinical translation;Code;CRISPR screen;CRISPR/Cas technology;Data;Development;Disease;DNA Sequence Alteration;Enhancers;epigenomics;Epithelial Cells;Epithelial ovarian cancer;Evolution;Gene Expression;Genes;Genetic;Genetic Code;Genetic Risk;genetic variant;Genetic Variation;Genome;genome editing;genome sequencing;genome wide association study;genome-wide;genome-wide analysis;Genomic Segment;Genotype;Germ Lines;Germ-Line Mutation;Goals;Heritability;Human Genetics;In Vitro;Interdisciplinary Study;Intervention;Invaded;Knowledge;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Maps;Modeling;Molecular Conformation;mortality;Mutate;Mutation;novel;Nucleotides;Outcome;Ovarian;ovarian neoplasm;Pathogenesis;Penetrance;Phenotype;population based;precursor cell;Prevention approach;programs;Proteins;Regulator Genes;Regulatory Element;Research;risk variant;Role;Somatic Mutation;spheroids;Susceptibility Gene;Syndrome;three-dimensional modeling;Tissues;tool;TP53 gene;trait;transcription factor;treatment response;tumor;Untranslated RNA;Validation;Variant;whole genome

PROJECT_TITLE: Characterizing non-coding somatic and germline variant interactions in ovarian cancer

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: GREENSBORO

ORG_DEPT: BIOLOGY

ORG_NAME: NORTH CAROLINA AGRI & TECH ST UNIV

ORG_STATE: NC

PHR: Project Narrative The overarching goal of this research is to improve our understanding of the biopsychosocial factors that impact cognitive outcomes among middle-aged and older Black adults. This study, known as the Black American United Memory and Aging Project (BA-UMAP), will establish and remotely assess a cohort of 600 middle-aged and older Black adults in order to identify the sociocultural, behavioral, environmental, and biological factors influencing cognitive functioning and cognitive decline, as measured by established and novel online and mobile cognitive assessments, and remotely collected non-invasive biomarkers. It is hoped that this work will inform risk reduction strategies, given Black adults are disproportionately affected by Alzheimer’s disease and related dementias.

PI_NAMEs: BROWN-HUGHES, TRAVONIA S (contact);GRAHAM, STEWART F;THORPE, ROLAND J.

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Acceleration;Adult;Affect;Age;Age Years;aged;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Assessment tool;Behavioral;Biological;Biological Factors;Biological Markers;Biomedical Research;biopsychosocial factor;Black American;black men;Black Populations;Black race;black women;Blood Vessels;cardiometabolism;Cellular Phone;Clinical;Clinical Research;Cognitive;cognitive change;cognitive function;cognitive testing;cohesion;cohort;Collection;college;Computers;cost;Data;Data Collection;Dementia;deprivation;Diagnosis;Diet;digital media;Discrimination;Disease;Disparity;Early Diagnosis;Education and Outreach;Enrollment;Environmental Risk Factor;ethnic minority;Etiology;executive function;Exposure to;Family;Family history of;follow-up;Fostering;Foundations;Fright;Genetic;Geography;Goals;Habits;handheld mobile device;Health;health determinants;health disparity;health equity;health literacy;High Prevalence;Impaired cognition;improved;indexing;Individual;Individual Differences;individual variation;Inflammation;Inflammatory;innovation;Internet;Intervention;Length;Life Style;Low income;Measures;Memory;Mental Depression;Methods;middle age;Minority;minority health;mobile application;Modality;neighborhood disadvantage;Neighborhoods;novel;novel strategies;online community;Outcome;Participant;Patient Self-Report;perceived discrimination;physical inactivity;Population;preference;Prevalence;prevent;Privatization;processing speed;prospective;protective factors;Questionnaires;racial minority;racism;Recording of previous events;recruit;Religiosity;remote administration;remote assessment;Reporting;Research;research study;resilience factor;Risk;Risk Factors;Risk Reduction;Saliva;Salivary;sample collection;Sampling;screening;Self Efficacy;social;social culture;social engagement;socioeconomics;Specimen;Stigmatization;Stress;stressor;telomere;Testing;Time;tool;Transportation;Trust;Uncertainty;Urine;Vascular Diseases;Work

PROJECT_TITLE: The Black American United Memory & Aging Project (BA-UMAP): An examination of cognitive decline in midlife and older Black adults using remote cognitive assessments, risk factors & biomarkers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(55)]


ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: OVERALL: PROJECT NARRATIVE Release of radionuclides after an industrial or medical radiological accident or detonation of a nuclear device may result in significant radionuclide exposure of general population. This program entwines projects that develop tools and approaches to evaluate, model and mitigate such exposures and their health threat.

PI_NAMEs: WOLOSCHAK, GAYLE E. (contact)

PROGRAM_OFFICER_NAME: WINTERS, THOMAS A

PROJECT_TERMS: Address;Age;Animal Model;Architecture;Biological;Biological Markers;Biological Models;Cells;Chemicals;Chemistry;Communities;data modeling;Daughter;Development;Devices;DNA;dosimetry;Educational process of instructing;Evaluation;Excision;Exposure to;External Beam Radiation Therapy;Fluorescence Microscopy;General Population;genetic makeup;Goals;Half-Life;Health;Histology;human model;Immune system;Immunohistochemistry;improved;in silico;Industrialization;Information Distribution;Intake;internal radiation;Knowledge;Literature;Measurement;Medical;Metabolism;migration;model development;Modeling;molecular marker;Morphology;novel;Nuclear;Nuclear Accidents;Organ;particle;Particle Size;phantom model;pharmacokinetics and pharmacodynamics;Physiology;Process;programs;Radiation;Radiation Accidents;Radiation Physics;Radiobiology;Radiochemistry;Radioisotopes;Reaction;Recording of previous events;Research;Roentgen Rays;Route;Science;sex;Signal Transduction;Solubility;Specificity;Structure;Technology;tissue repair;Tissues;tool;Toxic effect;uptake;virtual

PROJECT_TITLE: Multi-Scale Evaluation and Mitigation of Toxicities Following Internal Radionuclide Contamination


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: ATHENS

ORG_NAME: NYTRICX INC.

ORG_STATE: GA

PHR: Narrative Nytricx is developing a new class of Nitric Oxide (NO)-releasing intravascular medical catheters to combat infection and thrombosis associated with indwelling vascular catheters. Nytricx NO-releasing technology represents a disruptive innovation that will result in saving patients’ lives and cutting medical costs, especially those related to hospital acquired blood steam infections and thrombosis, associated with intravascular catheters.

PI_NAMEs: SHEBUSKI, RONALD J. (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Adhesions;Affect;Anti-Infective Agents;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Back;Bacteremia;Bacteria;Bacterial Adhesion;base;Binding;Bioreactors;Blood;Blood coagulation;Blood Platelets;Blood Vessels;Body part;catheter related infection;Catheters;Cells;Cessation of life;Chronic;chronic infection;Clinical;combat;Communities;Data;design;Development;Devices;Environment;Extracellular Matrix;Failure;Fibrinogen;Frequencies;Gases;Glycocalyx;hemocompatibility;Hemolysis;Heparin;Hospitals;Human;hydrophilicity;Immobilization;Immune;In Vitro;in vivo;Infection;Infection prevention;innovation;Invaded;Kinetics;Life;Liquid substance;Mechanics;Medical;Medical Care Costs;Microbial Biofilms;microorganism;Modeling;mortality;Nitric Oxide;Nitric Oxide Donors;Nosocomial Infections;novel;Nutritional;Oryctolagus cuniculus;Patients;pharmacologic;Phase;physical property;Platelet Activation;Polymers;prevent;Prevention;Proliferating;Property;Protein Structure Initiative;Proteins;Pseudomonas aeruginosa;Reporting;Resistance;Risk;side effect;Silicone Oils;Silicones;Solid;stability testing;Staphylococcus aureus;Steam;Stream;Surface;Technology;Temperature;Tensile Strength;Therapeutic Embolization;Thromboembolism;Thrombosis;thrombotic;Thrombus;Time;Veins;venous thromboembolism;Venous Thrombosis

PROJECT_TITLE: Ultra-low Fouling and Anti-infective and Anti-thrombotic Nitric Oxide Releasing Intravascular Catheters


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative As one of four Centers of Excellence (COEs) of FDA's Center for Food Safety and Applied Nutrition, JIFSAN conducts various research and outreach activities in food safety and applied nutrition to help ensure that regulatory decisions have a sound science footing and that the best methods and tools are available to advance food and public health. The JIFSAN's programs support the Food Safety Modernization Act that emphasizes the concept of preventing food safety-related problems before they occur and enhance FDA's efforts to partner with other nations to improve U.S. and worldwide health.

PI_NAMEs: MENG, JIANGHONG  (contact)

PROGRAM_OFFICER_NAME: RANDOLPH, KELLY

PROJECT_TITLE: Cooperative Agreement to Support the Joint Institute for Food Safety and Applied Nutrition (JIFSAN)


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: NARRATIVE Many patients that are suffering with Lyme disease experience chronic symptoms despite having undergone extensive antibiotic therapy and appear to be free of infection. The lead investigator of this proposal discovered that 1) the disease-causing agent sheds a component of its' cell-wall into its environment; 2) this molecule can be detected in patients' months after antibiotics; and 3) the cell-wall, alone, is capable of causing disease pathology. In this project we will determine what about the cell-wall is making us sick and how it is doing so, with the hope that we will be able to leverage this information to treat Lyme disease patients, even when antibiotics fail.

PI_NAMEs: JUTRAS, BRANDON LYON (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Accounting;Acute;Adjuvant;Affect;Anabolism;Anatomy;Animals;Antibiotic Therapy;Antibiotics;Antigens;Arthritis;Automobile Driving;Bacteria;Biopolymers;Borrelia;Borrelia burgdorferi;Cardiac;Cell Wall;Cells;Chemicals;Chemistry;Chronic;Comparative Study;Complex;conventional therapy;Cytotoxic T-Lymphocytes;Data;Disease;Environment;Epidemic;experience;experimental study;flu;Functional disorder;Growth;Half-Life;Heart;Human;human pathogen;immune activation;Immune response;immunoregulation;in vivo;Inbred Strains Mice;Incidence;Infection;Inflammation;innovation;insight;Intravenous;Isotope Labeling;Joints;Label;Lead;lens;Life Cycle Stages;Lyme Arthritis;Lyme Disease;lyme pathogenesis;Mediating;Molecular;mouse model;Mus;mutant;Neurologic;neuromusculoskeletal;novel;Oral;Organ;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathology;Patients;Peptidoglycan;persistent symptom;Phase;Play;Post Treatment Lyme Disease Syndrome;Research Personnel;Resolution;Role;Severities;Specificity;Symptoms;Synovial Fluid;System;Techniques;Testing;theories;Thinking;Ticks;Tissues;TLR2 gene;Toxin;United States;Vector-transmitted infectious disease;virtual

PROJECT_TITLE: Defining the host and pathogen determinants of peptidoglycan induced pathophysiology in Lyme disease


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Pain Research;Physical Activity;Prevention;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Unhealthy drinking can exacerbate two highly prevalent HIV-related comorbidities/co-occurring conditions, chronic pain and physical inactivity, which in turn, can intensify alcohol use and affect physical and mental function in people living with HIV (PLWH). In this Program Project, we will conduct state-of-the-art e-health clinical trials research on scalable approaches to address the HIV-associated conditions chronic pain and physical inactivity in PLWH with unhealthy alcohol use. We will also support secondary analyses of the existing Boston ARCH cohort of PLWH with unhealthy drinking, and provide support and mentoring to trainees and investigators accessing the cohort data.

PI_NAMEs: STEIN, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;addiction;Address;Affect;alcohol and other drug;Alcohol consumption;alcohol misuse;Alcohol or Other Drugs use;alcohol research;alcohol use disorder;Alcohols;antiretroviral therapy;Behavioral;Biometry;Boston;Cardiovascular Diseases;Caring;chronic pain;chronic painful condition;Clinical Trials;cohort;Collaborations;Communities;community setting;comorbidity;Complex;Data;Data Analyses;data management;Disease;drinking;Drug usage;Ecological momentary assessment;Ecology;efficacy testing;eHealth;Enrollment;exercise intervention;extend lifespan;falls;frailty;functional status;Funding;Goals;Grant;Health;Health behavior;Heavy Drinking;HIV;HIV Infections;HIV/AIDS;Home;improved;Infection;Infrastructure;interdisciplinary approach;Interdisciplinary Study;interest;Intervention;Investigation;Lead;Life;Life Style;Measurement;Mediator;Medical;Medicine;mental function;Mentors;Methodology;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;older adult;Osteopenia;Outcome;Pain;pandemic disease;Participant;Patients;Persons;Pharmaceutical Preparations;Physical activity;Physical Function;physical inactivity;Play;Population;population based;Procedures;Productivity;programs;prospective;Psychology;Public Health;randomized trial;Randomized, Controlled Trials;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Risk;Role;secondary analysis;secondary outcome;Services;substance use;Sum;Testing;Translating;trial design;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Boston Alcohol Research Collaboration  on HIV/AIDS - Comorbidity Center (Boston ARCH CC)


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Immunotherapy;Rare Diseases

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

PHR: Project Narrative We recently found that a naturally occurring inherited change of one amino acid in an extracellular matrix protein called the lysyl oxidase propeptide (LOX-PP) results in worse oral cancer outcomes in people. Here we propose to investigate why the variant LOX-PP, unlike the more common LOX-PP, fails to bind to and regulate how a cell surface protein known as FGFR1 results in an immune cells including macrophages to control other immune cells and mesenchymal cells to promote cancer. Understanding molecular interactions between LOX- PP and FGFR1, and how this interaction controls how tumor cells, immune cells, and bystander cells communicate will help us to come up with new strategies to help control oral cancer.

PI_NAMEs: HAN, XIAOZHE ;TRACKMAN, PHILIP C (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Acceleration;Address;Affect;Affinity;Amino Acids;Anabolism;Anti-Inflammatory Agents;Attenuated;Binding;Biochemical Reaction;Biological Assay;Biological Products;Cancer Model;Cell Communication;Cell Line;Cell Surface Proteins;cell type;Cells;Clinical;Collagen;Connective Tissue;crosslink;Data;Deamination;Development;Dysplasia;efficacy evaluation;Elastin;Elements;enzyme activity;Enzyme Inhibitor Drugs;Enzymes;Exhibits;extracellular;Extracellular Matrix Proteins;Family;FGF2 gene;FGFR1 gene;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Fibrosis;Gene Expression;Genes;Genetic Polymorphism;Genotype;Head and Neck Cancer;Human;Immune;Immune Cell Suppression;Immune checkpoint inhibitor;immunoregulation;immunosuppressive macrophages;improved outcome;In Vitro;in vivo;Inflammatory;Inherited;inhibitor;Injections;Knock-in;Knock-in Mouse;Knockout Mice;Length;Lesion;Link;loss of function;Lysine;Macrophage;Malignant Breast Neoplasm;malignant mouth neoplasm;Malignant Neoplasms;malignant stomach neoplasm;Mediating;member;Mesenchymal;Modeling;mouth squamous cell carcinoma;Mus;mutant;Mutation;Neoplasm Metastasis;neoplastic cell;novel;Operative Surgical Procedures;Oral;Outcome;overexpression;Pathway interactions;Patients;Persons;Phenotype;Point Mutation;programmed cell death ligand 1;Property;Protein Isoforms;Protein-Lysine 6-Oxidase;Publishing;Quality of life;Radiation;Radiation therapy;Recombinants;Regulation;Reporter;response;Role;Sampling;Signal Pathway;Signal Transduction;small molecule;Squamous Cell Neoplasms;Structure;Surface Plasmon Resonance;Survival Rate;T-Cell Activation;T-Lymphocyte;Technology;Testing;Therapeutic;Tissues;Tongue;Tongue Squamous Cell Carcinoma;transcriptome sequencing;transcriptomics;tumor;tumor growth;tumor microenvironment;Tumor Suppression;Tumor Suppressor Proteins;Tumor-associated macrophages;tumor-immune system interactions;Variant

PROJECT_TITLE: Mechanism of lysyl oxidase propeptide in oral squamous cell carcinoma microenvironments

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative Tooth delay and loss are common problems, and little is known in enamel regeneration from human cell source. The proposed research aims to develop a well-defined 3D material microenvironment for regulating self-renewal and differentiation of human induced pluripotent stem cells (hiPSCs), producing scaffold-grown tooth germ in vitro, and generating tooth tissue from scaffold-grown tooth germ in a clinically-relevant orthortopic mouse model. Successful completion of the proposed research will make a profound impact on stem-cell biology and technology and on human tooth tissue regeneration.

PI_NAMEs: ZHANG, MIQIN  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 3-Dimensional;Adult;Alginates;Ameloblasts;Animals;Architecture;Biology;biomaterial compatibility;Biomedical Engineering;Cell Communication;Cell-Matrix Junction;Cells;Cellular Morphology;chemical property;Chemicals;Chitosan;clinical material;clinically relevant;Coculture Techniques;Communities;Complex;Dental;Dental caries;Dental Enamel;Dental Pulp;Dentin;Dentures;Development;Edentulous Mouth;embryo cell;Engineering;epithelial stem cell;Epithelium;Evaluation;Extracellular Matrix;Freeze Drying;Genetic Markers;Glycosaminoglycans;Growth;Growth Factor;Growth Inhibitors;Harvest;Human;human adult stem cell;human induced pluripotent stem cells;human pluripotent stem cell;Hybrids;immunogenicity;Implant;implantation;In Vitro;in vitro regeneration;in vivo;mechanical properties;Mesenchymal;Mesenchymal Stem Cells;Molecular;Morphogenesis;Morphology;mouse model;Natural regeneration;Neural Crest Cell;Nude Mice;Odontogenesis;Oral cavity;pluripotency;Polymers;Porosity;Proliferating;Property;Proteins;Proxy;Regenerative capacity;repaired;Research;scaffold;self-renewal;Shapes;Signal Pathway;Signal Transduction;Site;Source;spheroids;stem cell biology;stem cell division;stem cell therapy;stem cells;Structure;Techniques;Technology;Testing;Time;Tissue constructs;tissue regeneration;tissue support frame;Tissues;Tooth eruption;Tooth Germ;Tooth Loss;Tooth regeneration;Tooth structure;Tooth Tissue;Transplantation;Undifferentiated

PROJECT_TITLE: Bioengineered 3D tooth germs for tooth regeneration in vitro and in vivo

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse;Underage Drinking

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative As the prevalence of children being born to opioid-dependent mothers has increased, there is a pressing need to understand the mechanisms whereby prenatal opioid exposure increases the susceptibility for problematic substance use, particularly alcohol given its widespread accessibility and the significant morbidity and mortality associated with alcohol use disorder. Using a mouse model of prenatal exposure to methadone, a commonly used opioid in pregnant women, we found that prenatal methadone exposure increases alcohol drinking exclusively in male offspring, consistent with literature showing males are more sensitive to prenatal opioid exposure. Here we use a multidisciplinary approach, that extends from the synaptic proteome to the behavioral level, to explore the interaction of prenatal methadone exposure and alcohol on specific corticostriatal synapses that mediate excessive alcohol drinking behaviors in order to determine the mechanisms whereby prenatal methadone exposure produces enhanced alcohol drinking in males.

PI_NAMEs: ATWOOD, BRADY  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Ablation;Abstinence;Address;Affect;Alcohol abuse;alcohol behavior;Alcohol consumption;alcohol effect;alcohol exposure;alcohol response;alcohol use disorder;Alcohols;AMPA Receptors;Anatomy;Anterior;Award;Behavioral;behavioral response;binge drinking;Biochemical;Birth;Brain;Brain region;cell type;Child;Clinical;Clinical Research;clinically relevant;Confocal Microscopy;Corpus striatum structure;Data;density;Dorsal;drinking;drinking behavior;Electrophysiology (science);experience;Exposure to;Female;fetal opioid exposure;Fetal Tissues;Future;Glutamates;Grant;Heavy Drinking;Home;in vivo;Incidence;Individual;insight;Institution;interdisciplinary approach;Interneurons;Knowledge;Label;Laboratories;Literature;Long-Term Depression;male;Measurement;Measures;Mediating;Methadone;Microscopy;Modeling;Molecular;Morbidity - disease rate;mortality;Mothers;mouse model;Mus;N-Methyl-D-Aspartate Receptors;Neonatal;neural;Neurons;novel;offspring;Opiate Addiction;opioid exposure;opioid misuse;opioid use;opioid use disorder;opioid use in pregnancy;opioid withdrawal;optogenetics;Pathway Analysis;Pathway interactions;phosphoproteomics;Phosphorylation;Physiological;Population;postsynaptic;preclinical study;Predisposition;Pregnant Women;prenatal;prenatal exposure;prenatal testing;prescription opioid;presynaptic;Prevalence;Proteins;Proteome;Proteomics;receptor function;Recording of previous events;Replacement Therapy;Reporter;resilience;Resistance;response;Rewards;Role;Saline;Shapes;Slice;Source;standard of care;stimulant misuse;substance misuse;substance use;Sucrose;Synapses;synaptic function;synaptic inhibition;Synaptic plasticity;Synaptic Transmission;synergism;Testing;Time;transmission process;Water;wireless;Work

PROJECT_TITLE: Impact of prenatal opioid exposure on corticostriatal circuits that modulate alcohol-related behaviors

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: PITTSBURGH

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: SenNet CODCC Supplement Project Narrative The purpose of the Supplement is to further the CODCC Administrative Core in three areas: 1. onboarding and integrating new additional murine awards; 2. management and growth of the CUSP Consortium Underrepresented Student Program; 3. expanding in person consortium activities, in particular to include engagment with the corporate ecosystem including pharmaceutical development related to Cellular Senescence.

PI_NAMEs: BAR-JOSEPH, ZIV ;BLOOD, PHILIP D.;SILVERSTEIN, JONATHAN C. (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Area;Award;Biology;Biotechnology;Businesses;Cell Aging;Cells;Collaborations;Collection;Communication;Communities;Computer Models;Data;Data Analyses;data management;data platform;data standards;Development;drug discovery;Ecosystem;Education;Educational workshop;Environment;experience;Funding;Growth;hackathon;Human;Ingestion;interest;Internships;Knowledge;Laboratories;Learning;manufacture;Manufacturer;meetings;member;Mentors;Metadata;Mus;outreach;Persons;Pharmaceutical Preparations;Pharmacologic Substance;programs;rapid growth;Research;Science;senescence;skills;Students;System;Tissue atlas;undergraduate student;Underrepresented Students;United States National Institutes of Health;Vendor;Visualization software;working group

PROJECT_TITLE: 2024 SenNet CODCC Supplement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(71)-R]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Social Determinants of Health

ORG_CITY: MIAMI

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE Men are missing from mental health care and family-focused research; their inclusion through scalable, relevant treatment can improve the burden of mental health problems especially in low-resource settings where treatment gaps are largest. The proposed K23 supports the candidate’s transition to a research career designing and testing scalable interventions for caregiver mental health to improve child mental health in low- resource settings that consider social determinants of health focused on men and father. The resulting knowledge can inform public health policy and intervention strategies to reduce the global burden of mental disorders for men, and subsequently children and family members.

PI_NAMEs: GIUSTO, ALI  (contact)

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Adverse event;Age;Automobile Driving;Award;Behavior;Behavioral;career;caregiver interventions;Caregivers;Case Series;Child;Child Mental Health;Child Rearing;Clinical;clinical outcome assessment;Clinical Trials;Communities;Competence;Control Groups;Data;Dedications;depressive symptoms;design;Development;disability;drinking;drinking behavior;Economic Factors;Economics;Educational process of instructing;Effectiveness;effectiveness testing;effectiveness/implementation design;effectiveness/implementation hybrid;effectiveness/implementation trial;efficacious intervention;efficacious treatment;Equation;Family;Family member;Fathers;Focus Groups;Future;Gender;Goals;Health;Health Policy;Home;Hospital Referrals;hybrid type 1 design;Hybrids;Impairment;implementation facilitators;implementation outcomes;implementation science;implementation strategy;implementation/effectiveness;improved;Intervention;Interview;Kenya;Knowledge;knowledge of results;Learning;Link;low and middle-income countries;maladaptive behavior;Masculine;Mediator;men;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentorship;Meta-Analysis;Methods;Modeling;motivational enhancement therapy;National Institute of Mental Health;Outcome;Parents;Participant;Partnership Practice;Pathway interactions;Patients;Pattern;peer;Personal Satisfaction;Persons;Poverty;pressure;primary outcome;process evaluation;Professional counselor;Provider;Public Health;Publications;Questionnaires;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Research Personnel;Resource-limited setting;response;retention rate;satisfaction;scale up;secondary outcome;Services;skills;social health determinants;social stigma;Stress;Surveys;symposium;Testing;Training;Transcript;Waiting Lists;Woman;Work;Youth

PROJECT_TITLE: A brief, task-shifted treatment to improve father depression and child outcomes in Kenya: A pilot effectiveness-implementation trial

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]