ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative (Overall): This P01 application from investigators at Stanford University seeks to discover, apply, and translate science about pancreatic cancer (PDAC), with the ultimate goal of improving care for patients with this disease. To address fundamental, persistent questions about the biology of PDAC, we have assembled a superb, interactive team of productive collaborators to lead our Projects and Research Cores that will identify genetic, immune cell, and cancer-associated fibroblasts based interactions and pathways that regulate the inception and progression of PDAC. Advances from studies proposed here could broadly impact pancreas cancer biology and drive translational efforts in PDAC.

PI_NAMEs: ATTARDI, LAURA D;KIM, SEUNG K (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Acceleration;Acinar Cell;Address;Affect;Amplifiers;Biology;Biostatistics Core;Cancer Biology;cancer cell;candidate identification;Carcinoma;Cell Compartmentation;Cell Ontogeny;cell type;Cells;Chronic;Collaborations;Conceptions;Data;Data Analyses;Data Set;Dedications;Dependence;Detection;Development;diagnostic strategy;Disease;driver mutation;Duct (organ) structure;Ductal Epithelial Cell;empowerment;Epithelial Cells;Epithelium;Evolution;Fibroblasts;Frustration;Generations;Genetic;genetic resource;Genetically Engineered Mouse;Genotype;Goals;high dimensionality;Human;human tissue;Image;Imaging technology;Immune;Immune Evasion;Immune response;Immune signaling;Immunobiology;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;indexing;Infiltration;Inflammation;Inflammatory;infrastructure development;innovation;Investigation;KRAS2 gene;Lead;Learning;lymph nodes;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;medical schools;member;Metaplasia;Molecular;mouse model;Mus;Mutation;Neoplasm Metastasis;novel;novel diagnostics;Pancreas;pancreas development;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pancreatic Intraepithelial Neoplasia;Pathway interactions;Patient Care;Preparation;Prevention strategy;Process;Productivity;programs;Research;Research Personnel;Resistance;Resource Sharing;Resources;response;Risk;Role;Science;search engine;Shapes;Signal Transduction;stem cells;stemness;targeted treatment;Therapeutic;Tissue Procurements;Tissues;tool;Translating;translational impact;tumor;tumor microenvironment;Universities;Work

PROJECT_TITLE: Pancreatic Cancer Development: Genetic and Immune Regulation


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Hematology;Neurosciences;Prevention;Stroke

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Chronic, daily, oral anticoagulation reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage, including fatal hemorrhage, even during long periods of sinus rhythm when the risk of cardioembolic stroke is low. This study will compare the current standard of care of continuous anticoagulation with a novel approach of targeted, time-delimited anticoagulation therapy guided by an AF-sensing smartwatch. If successful, this paradigm shift toward individualized or “precision” stroke prevention could reduce anticoagulant use, hemorrhage risk, healthcare utilization and cost for millions of AF patients worldwide.

PI_NAMEs: HANLEY, DANIEL F (contact);THOMPSON, RICHARD ;YENOKYAN, GAYANE

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: Anticoagulants;Anticoagulation;Apple watch;Area;Arrhythmia;Atrial Fibrillation;Benefits and Risks;Blinded;Blood Cells;Caring;Chronic;Clinical;Clinical Trials;comparative efficacy;Compartment syndromes;cost;design;efficacy evaluation;Elements;Embolism;Erythrocytes;Evaluation;Event;evidence base;experimental arm;Exposure to;falls;Goals;Health;health care service utilization;Hemoglobin concentration result;Hemorrhage;Hemostatic function;high risk;Hour;improved;innovation;International;Intramuscular;Ischemic Stroke;Monitor;mortality;novel;novel strategies;open label;Oral;Organ;Outcome;Participant;Patients;Pericardial body location;Phase;precision medicine;prospective;Quality of life;Randomized;Recording of previous events;Resources;response;Retroperitoneal Space;Risk;Risk Reduction;Safety;satisfaction;Sinus;smart watch;Societies;standard of care;Stroke;Stroke prevention;stroke risk;Technology;Testing;Therapeutic;Thrombosis;Time;Transfusion;treatment strategy;trial comparing;two-arm study;Vision;wearable device;Whole Blood

PROJECT_TITLE: 2/2  REACT-AF: Rhythm Evaluation for AntiCoagulaTion with Continuous Monitoring of Atrial Fibrillation

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

ORG_STATE: CA

PI_NAMEs: HURA, GREGORY L (contact)

PROJECT_TERMS: Address;Amino Acid Sequence;archive data;beamline;Biocompatible Materials;Biological;Collaborations;Collection;Communication;Communities;Complex;computer infrastructure;Computer software;computerized data processing;Country;Coupled;Coupling;COVID-19;Cryoelectron Microscopy;Crystallography;Darkness;Data;Data Analyses;Data Collection;design;Educational workshop;Electron Microscopy;Ensure;Exclusion;experimental study;flexibility;Funding;Future;Goals;Hand;Health;Home;Human;improved;Infrastructure;insight;instrumentation;Laboratories;macromolecular assembly;macromolecule;Mission;Modeling;Molecular Conformation;Molecular Structure;Nuclear Magnetic Resonance;operation;outreach;pandemic disease;Pathway interactions;peer;Photons;Process;Productivity;programs;Property;Protein Engineering;Proteome;Publications;Reporting;Research Personnel;Resolution;Resource Sharing;Roentgen Rays;Role;Running;Sampling;Schedule;Site;Source;Speed;Structural Biologist;structural biology;Structure;symposium;Synchrotrons;System;Techniques;Technology;Testing;tool;Vertebral column;web app;web-based tool;X-Ray Crystallography

PROJECT_TITLE: High quality and high throughput Small‐Angle X‐ray Scattering

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BCMB-P]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PI_NAMEs: PITPITAN, EILEEN VIRTUSIO (contact)

PROJECT_TERMS: Accountability;Climate;cohort;Collaborations;Communication;Data;Data Analyses;Data Sources;design;Development;early-career faculty;equity, diversity, and inclusion;Evaluation;evidence based guidelines;Evidence based practice;Faculty;Feedback;follow up assessment;Goals;Grant;health science research;Impact evaluation;improved;Individual;Institution;Institutionalization;Interview;Leadership;Measurement;Measures;member;Mentors;Methods;model design;multiple data sources;Outcome;Peer Review;Process;Productivity;programs;Publications;recruit;Research;Schools;Science;STEM program;success;Surveys;Teacher Professional Development;Testing;Time;Universities;women faculty

PROJECT_TITLE: SDSU FUERTE: Evaluation Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-Y]


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence

PI_NAMEs: HOLTON, JAMES M (contact)

PROJECT_TERMS: Acoustics;Active Sites;Age;Artificial Intelligence;Attention;base;beamline;Binding;Biological;Biological Assay;Biological Sciences;Blood capillaries;Chemicals;Collaborations;Collection;Communities;Computer software;COVID-19;Cryoelectron Microscopy;Crystallization;Crystallography;Data;data access;Data Analyses;Data Collection;data quality;Data Set;Decision Making;design;Devices;Diagnostic;Diagnostic Procedure;Diagnostic tests;Dimethyl Sulfoxide;Disease;Drops;Elements;Epiphysial cartilage;experimental study;Familiarity;Feedback;flexibility;Fostering;Geography;Goals;Growth;Harvest;Health;Image;improved;In Situ;Individual;insight;Libraries;Ligands;Liquid substance;Location;Machine Learning;Maps;Mathematics;Measurement;Measures;Metals;Methods;Modeling;Molecular;Molecular Conformation;Motion;multiple datasets;Noise;operation;Optics;Phase;predictive tools;Preparation;Procedures;Process;Property;Proteins;Protocols documentation;Research Project Grants;Resistance;Resolution;Resources;Robot;Robotics;Roentgen Rays;Sampling;screening;Services;Shapes;Signal Transduction;small molecule;Source;structural biology;Structure;success;Synchrotrons;System;Techniques;Technology;Temperature;Tertiary Protein Structure;Testing;tool;Training;Visualization

PROJECT_TITLE: Flexible Macromolecular Crystallography


PI_NAMEs: RALSTON, CORIE Y (contact)

PROJECT_TERMS: Automation;Award;base;beamline;Binding;Biological;biological systems;Buffers;Chemistry;chromophore;Collection;Communities;Complex Mixtures;Computer software;Crystallography;Data;data access;Data Analyses;Data Collection;Databases;Deuterium;Development;Diameter;Digestion;Dose;Exclusion;experimental study;Exposure to;Fingerprint;flexibility;Fluorescence;Fluorescence Spectroscopy;Grant;Hour;Hybrids;Hydrogen;Hydroxyl Radical;In Situ;Individual;instrument;instrumentation;Investigation;Kinetics;Label;Laboratories;Learning;Liquid Chromatography;liquid chromatography mass spectrometry;Liquid substance;macromolecular assembly;macromolecule;Maps;Mass Spectrum Analysis;Methods;Molecular Conformation;Molecular Sieve Chromatography;National Institute of General Medical Sciences;Nucleic Acids;operation;Positioning Attribute;Process;protein complex;protein structure;Proteins;Protocols documentation;Pump;Raman Spectrum Analysis;Reporting;Resources;Roentgen Rays;sample collection;Sampling;Shotguns;Signal Transduction;Site;Solvents;spectroscopic data;Spectrum Analysis;Speed;structural biology;Structure;success;Syringes;System;Technology;Time;time use;tool;Tube;web site;X ray spectroscopy

PROJECT_TITLE: High throughput X-ray footprinting mass spectrometry (XFMS)


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Little is known about how genomic variants affect human postnatal development, function, and lead to disorders. To address this, we propose a large-scale study to identify DNA variants and their effects on gene expression and regulation in many tissues and cell types across human brain development. This will provide unprecedented functional insights into human development.

PI_NAMEs: GERSTEIN, MARK BENDER;HUTTNER, ANITA JULIANE;MANE, SHRIKANT M;MILOSAVLJEVIC, ALEKSANDAR ;SESTAN, NENAD  (contact);ZHAO, HONGYU

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Address;Adolescence;Adult;Affect;Age;age group;Alleles;Animals;Area;Atlases;biobank;Biologic Characteristic;Biological;Birth;Brain;BRAIN initiative;Brain region;Cell Nucleus;cell type;Cells;Censuses;Childhood;Chromatin;Collaborations;Collecting Cell;Communities;Complement;Consent Forms;critical period;Data;Data Analyses;data dissemination;data integration;data portal;Databases;Development;Dimensions;Disease;DNA;early childhood;Epigenetic Process;fetal;functional genomics;Funding;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Generations;Genes;genetic variant;genome sequencing;genome wide association study;genomic data;genomic locus;Genotype;Genotype-Tissue Expression Project;histopathological examination;Human;Human Development;human disease;infancy;insight;Knowledge;Laboratories;Life;Link;Mammals;Measures;Modification;Monitor;multimodal data;multimodality;multiple omics;Neocortex;Organ;Pattern;perinatal period;Population;postnatal;postnatal development;postnatal human;postnatal period;prenatal;Production;Protocols documentation;Quality Control;Quantitative Trait Loci;Recommendation;Regulation;Reporting;Research;Resolution;Resources;Review Committee;Risk;RNA Splicing;Sampling;single nucleus RNA-sequencing;Specimen;Spliced Genes;Standardization;System;Testing;Tissue Procurements;Tissues;transcriptome;transcriptome sequencing;Untranslated RNA;Variant;Whole Blood

PROJECT_TITLE: Laboratory, Data Analysis, and Coordinating Center (LDACC) for the Developmental Human Genotype-Tissue Expression Project


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE (Project 1) Pancreatic cancer is particularly deadly because few symptoms manifest until late in disease development and because treatment options are ineffective. Developing improved early diagnosis strategies is therefore critical. This research aims to gain a detailed understanding of the earliest steps of pancreatic cancer development by defining the cell type from which it originates and the genetic events involved, essential first steps toward reducing mortality from this disease.

PI_NAMEs: ATTARDI, LAURA D (contact)

PROJECT_TERMS: Acinar Cell;Affect;Aging;Alleles;Bar Codes;cancer care;cancer cell;cancer genetics;cancer initiation;carcinogenesis;CDKN2A gene;cell type;Cells;Chromosome Mapping;chronic pancreatitis;Clinical;Clinical Management;Clonal Expansion;CRISPR/Cas technology;Data;design;Development;Disease;Duct (organ) structure;Ductal Epithelial Cell;Early Diagnosis;Early treatment;Epithelial Cells;Event;Evolution;Gene Expression;Gene Expression Profile;Genetic;Genetic Determinism;Genetically Engineered Mouse;genome editing;genome sequencing;Genotype;High-Throughput Nucleotide Sequencing;Homeostasis;Human;Immune;immunoregulation;improved;in vivo;innovation;insight;Intervention;Knowledge;KRAS oncogenesis;KRAS2 gene;KRASG12D;Lesion;MADH4 gene;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Metaplasia;Modeling;Molecular;mortality;mouse model;Mus;mutant;Mutate;Mutation;neoplastic;novel;Oncogenic;Pancreas;Pancreatic Ductal Adenocarcinoma;Pancreatic Intraepithelial Neoplasia;Pancreatitis;Pathway interactions;Positioning Attribute;premalignant;Process;Recurrence;reduce symptoms;regenerative;repaired;Research;Research Personnel;Risk;Risk Factors;Role;Route;single-cell RNA sequencing;somatic cell gene editing;synergism;System;Testing;TP53 gene;transcriptome;transdifferentiation;tumor;tumor initiation;tumor microenvironment;Tumor Suppressor Genes;Tumor-Suppressor Gene Inactivation;Variant;Viral

PROJECT_TITLE: Project 1: Elucidating the genetics and cell of origin of pancreatic cancer initiation


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Biotechnology;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Parkinson's Disease;Racial and Ethnic Minority Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Parkinson's disease (PD) is the second most common neurodegenerative disorder and affects people from all ethnic backgrounds. In the last 10 years we have gained considerable knowledge about the important role that genetics play in this disease, especially in populations of European and Asian ancestry; however, the genetic factors involved in understudied populations such as Latinos remain mostly unknown. This project will identify the genetic variants associated with PD in this understudied population, identifying additional therapeutic targets and improving diagnosis and risk prediction in Latinos, contributing to our understanding of differences in risk across diverse populations.

PI_NAMEs: FERNANDEZ MATA, IGNACIO  (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: Acceleration;Admixture;admixture mapping;Affect;Age;alpha synuclein;Americas;Argentina;Asian ancestry;bioinformatics tool;Brazil;Candidate Disease Gene;Caribbean region;case control;causal variant;Chile;Chromosomes;Clinical Trials;Code;cohort;Collaborations;Colombia;Complex;Copy Number Polymorphism;Costa Rica;Country;Data;Data Set;Databases;Development;Diagnosis;Disease;disorder risk;dosage;Ecuador;Enrollment;Ethnic Origin;European;European ancestry;exome;Family;Family history of;Family member;Frequencies;Funding;Future;gene discovery;Gene Mutation;Genes;Genetic;genetic analysis;genetic architecture;Genetic Diseases;genetic resource;Genetic study;genetic variant;Genetic Variation;Genome;genome sequencing;genome wide association study;genome-wide;Genomics;Genotype;Goals;Haplotypes;health disparity;Heritability;Hispanic Populations;Honduras;Human Genetics;improved;Individual;Institution;International;Knowledge;large datasets;Latin America;Latin American;Latino;Latino Population;LRRK2 gene;Maps;Meta-Analysis;Methods;Mexico;multi-ethnic;Mutation;Nervous System Disorder;Neurodegenerative Disorders;new therapeutic target;novel;Other Genetics;PARK2 gene;PARK7 gene;Parkinson Disease;Participant;Pathogenicity;Patients;personalized medicine;Persons;Peru;Phase;PINK1 gene;Play;polygenic risk score;Population;Population Heterogeneity;Predisposition;proband;public database;Puerto Rico;Recording of previous events;recruit;Reporting;Research;Rest;Risk;risk prediction;risk variant;Role;Sampling;Screening procedure;segregation;Series;Single Nucleotide Polymorphism;South America;success;Surveys;Susceptibility Gene;Testing;therapeutic target;therapy design;trait;Uruguay;Variant;virulence gene;whole genome;Work

PROJECT_TITLE: Identifying novel Parkinson'Âs disease genes exploring understudied Latino populations

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SALT LAKE CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative: The goal of this project is to develop and test at multiple centers a highly efficient and easily used MRI technique for the analysis and management of cervical carotid disease. We will accomplish this using multi- parametric non-contrast MRI sequences coupled with the latest high signal to noise ratio (SNR) neck-shape- specific (NSS) RF coils and innovative machine learning (deep neural network) analysis methods.

PI_NAMEs: ALTBACH, MARIA I.;DESHPANDE, VIBHAS ;LI, DEBIAO ;PARKER, DENNIS L (contact);SALONER, DAVID A;VOJTA, CHRISTOPHER

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: 3-Dimensional;Academic skills;Address;Arterial Fatty Streak;Atherosclerosis;Carotid Arteries;Carotid Artery Plaques;Carotid Atherosclerotic Disease;Cephalic;Cervical;Classification;Clinical;clinical practice;cohort;Collaborations;Community Hospitals;Computer software;Contrast Media;Coupled;Data;deep neural network;design;Diagnosis;Diameter;Disease;Equipment;Evolution;experience;Gadolinium;Goals;Histology;Histopathology;Image;imaging facilities;imaging modality;improved;innovation;Intervention;Investigation;Learning;Machine Learning;machine learning classification;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methods;Neck;Noise;Outcome;patient population;Patients;pharmacologic;Physiologic pulse;Population;Protocols documentation;Reading;Reporting;Reproducibility;Research Personnel;RF coil;Risk;Risk Assessment;Shapes;Signal Transduction;skills;Stenosis;stroke risk;success;System;Techniques;Technology;Testing;Time;tool;Training;user-friendly;Validation;Vendor

PROJECT_TITLE: Multi-Center Implementation and Validation of Efficient Magnetic Resonance Imaging and Analysis of Atherosclerotic Disease of the Cervical Carotid

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ORG_CITY: CHARLESTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Overall – Narrative While oxygen provides the most efficient way to produce energy through oxidative phosphorylation, paradoxically it also produces toxic byproducts. Through adaptation, organisms have evolved numerous redox based stress pathways to counteract this toxicity. In human diseases, these pathways can sometimes malfunction leading to a broad range of human maladies. This COBRE seeks to support faculty and their research in these areas with an agnostic viewpoint on the choice of disease. Our overall goal continues to be to build a sustainable Center that can provide a focal effort to comprehend the integral importance of redox stress signaling in human diseases and the treatment thereof.

PI_NAMEs: TEW, KENNETH D. (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Abbreviations;Accountability;Achievement;Advisory Committees;Analytical Biochemistry;Area;Automobile Driving;Award;base;Bioenergetics;Biology;Biomedical Research;Biotechnology;Cancer Center;Cardiovascular Diseases;career;Cells;Centers of Research Excellence;Collaborations;collaborative environment;college;commercial application;Complement;Core Facility;cost;design;Diabetes Mellitus;Discipline;Disease;Drug Addiction;Economics;Engineering;Equilibrium;Equipment;experience;Extramural Activities;Faculty;faculty support;Financial Support;Fostering;Funding;Gastrointestinal Agents;Gastrointestinal Diseases;Goals;Grant;Growth;Health;Homeostasis;Human;human disease;Human Pathology;Image;imaging capabilities;improved;Individual;Infrastructure;infrastructure development;Institution;Interdisciplinary Study;Intervention;Malignant Neoplasms;mass spectrometric imaging;Mass Spectrum Analysis;Medical;Medicine;member;Mentors;Metabolic dysfunction;microscopic imaging;Mission;Modeling;Molecular;multi-photon;multidisciplinary;Musculoskeletal;National Institute of General Medical Sciences;Neurodegenerative Disorders;new technology;novel;Organism;outreach;Oxidants;Oxidation-Reduction;Oxidative Phosphorylation;Oxidative Stress;Oxygen;Paper;Pathologic;Pathway interactions;Peer Review;Phase;Pilot Projects;Positioning Attribute;programs;Proteomics;Published Comment;Publishing;Recovery;recruit;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Role;Scientific Advances and Accomplishments;Secure;Services;Signal Transduction;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Source;South Carolina;Stress;success;Talents;targeted treatment;Teacher Professional Development;Therapeutic;Tissues;Toxic effect;Training;translational goal;Translational Research;ultra high resolution;United States National Institutes of Health;Universities;Workforce Development

PROJECT_TITLE: South Carolina COBRE in Oxidants, Redox Balance and Stress Signaling


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Accountability;Advisory Committees;Biology;career development;Centers of Research Excellence;Collaborations;Committee Members;Communication;cost;Data;design;Development;Ensure;Equilibrium;Evaluation;Faculty;Funding;Goals;Information Dissemination;Infrastructure;Institution;Leadership;Medical;member;Monitor;multidisciplinary;operation;Organizational Efficiency;organizational structure;Outcome;Oxidants;Oxidation-Reduction;Participant;Peer Review;Phase;Pilot Projects;Policies;Preparation;Principal Investigator;Process;programs;Progress Reports;Recovery;Recruitment Activity;Regulation;Reporting;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Services;Signal Transduction;South Carolina;Stress;success;Talents;Training;United States National Institutes of Health;Universities;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE (Project 2)  Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with a 5-year survival rate of less than 5%. The  extremely poor prognosis in PDAC is attributed to lack of early detection, complexity and aggressiveness of the  disease and importantly, resistance to conventional chemotherapy, radiotherapy and molecularly targeted  therapy. This is due to the complexity in PDAC characterized by several genetic, epigenetic alterations, dense  fibrosis and a dynamic immune environment that cross-talk with each other to drive cancer progression and  chemoresistance. Our study proposes to examine immune signals that facilitate communication between  immune, cancer and stromal cells to promote cancer progression. Our preliminary results have identified a novel,  pro-tumorigenic signaling pathway that links immune cells, cancer cells and stroma in PDAC. Using human  samples and experimental models of PDAC, we will study the mechanisms involved and examine the possibility  of therapeutically blocking this pathway to treat PDAC.

PI_NAMEs: ARTANDI, STEVEN E (contact)

PROJECT_TERMS: Acinar Cell;acute pancreatitis;Affect;cancer cell;cancer stem cell;cancer subtypes;carcinogenesis;Cell Communication;Cell Reprogramming;Cells;Chemoresistance;chemotherapy;Chronic;chronic pancreatitis;Communication;Development;dimensional analysis;Disease;driver mutation;Ductal Epithelial Cell;Early Diagnosis;Environment;Epigenetic Process;Experimental Models;Feedback;Fibroblasts;Fibrosis;Genetic;genetic approach;Genetic Engineering;Goals;Growth;Human;Immune;Immune signaling;immunoregulation;improved;In Vitro;in vivo;Infiltration;Inflammation;insight;interleukin-22;Lead;Link;LoxP-flanked allele;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Methods;molecular targeted therapies;mouse model;Mus;Neoplasm Metastasis;novel;Oncogenic;Pancreas;Pancreas Transplantation;pancreatic cancer cells;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pancreatic Intraepithelial Neoplasia;pancreatic stellate cell;Pancreatitis;Pathway interactions;Patients;Peripheral;pharmacologic;Phenotype;Platelet-Derived Growth Factor alpha Receptor;Play;Population;Process;Prognosis;Property;Radiation therapy;receptor;Recurrence;Regulation;Resistance;Risk Factors;Role;Sampling;selective expression;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;STAT3 gene;stemness;Stromal Cells;Survival Rate;synergism;Tamoxifen;Testing;Therapeutic;therapeutic evaluation;therapeutic target;tissue repair;TP53 gene;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenic;Tumorigenicity;Work

PROJECT_TITLE: Project 2: Immune signals promoting pancreas cancer stemness and progression


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Pediatric;Rural Health

ORG_CITY: IOWA CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Houtman/Lubaroff Narrative The proposed summer research training program, "Cancer Research Opportunities at Iowa", at the University of Iowa will include a research methods training, immersion in an outstanding research project, a course in cancer biology, career counseling, and follow-up after the students complete the summer research training program, and community involvement. Our plan is to train underrepresented students, both undergraduate and high school. We will also host faculty from these institutions to expose them to research projects and to learn about development and enhancement of the science curricula at their home institution.

PI_NAMEs: HOUTMAN, JON C.D. (contact);LUBAROFF, DAVID M.

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Academia;Address;Admission activity;African American;Alaskan;anti-cancer research;Award;Cancer Biology;Cancer Patient;cancer survival;career;Clinical Trials;college;community college;community involvement;Community Outreach;course development;design;Development;Disabled Persons;disadvantaged student;Doctor of Philosophy;Education;Educational Curriculum;Employment;Enrollment;experience;Exposure to;Faculty;follow-up;Foundations;Funding;Future;Generations;Goals;Government;high school;High School Student;Hispanic;Hispanic-serving Institution;Historically Black Colleges and Universities;Home;Immersion;Individual;Industry;Institution;Iowa;Latino;Leadership;Learning;Literature;Malignant Neoplasms;medical schools;meetings;Mentors;Minority;Native Americans;Pacific Islander;Performance;Play;Policies;Population;Postbaccalaureate;posters;Principal Investigator;Privatization;programs;Publishing;recruit;Research;Research Methodology;Research Project Grants;research study;Research Training;Rural;Schools;Science;Scientist;socioeconomic disadvantage;Students;success;summer program;summer research;teacher;Training;Training Programs;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Vocational Guidance;Youth

PROJECT_TITLE: R25 YES: Cancer Research Opportunities at Iowa

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: BALL, LAUREN ELIZABETH (contact)

PROJECT_TERMS: Acetylation;Address;Advanced Development;Agreement;Applications Grants;Arginine;Award;base;Bioinformatics;Biological Markers;Biology;Cancer Center Support Grant;Cells;Centers of Research Excellence;Complement;Computer software;computerized data processing;Consult;Consultations;cost;crosslink;Cysteine;data acquisition;Data Analyses;Dedications;Detection;Development;Disease;Disease Progression;Dissociation;disulfide bond;Drug resistance;Education;Electron Transport;Ensure;Enzymes;Equilibrium;Evaluation;experience;Experimental Designs;experimental study;Faculty;Freezing;glycation;glycosylation;Goals;Grant;Human Resources;imaging capabilities;improved;in vivo;Infrastructure;Institution;instrument;instrumentation;Investments;Lysine;mass spectrometric imaging;Mass Spectrum Analysis;Methodology;Modification;nano;National Institute of General Medical Sciences;new technology;novel;Oxidants;oxidation;Oxidation-Reduction;Peptide Fragments;Peptides;Phase;Phosphorylation;Positioning Attribute;Post-Translational Modification Site;Post-Translational Protein Processing;Preparation;programs;Proline;protein expression;Proteins;Proteomics;Pyruvaldehyde;Reproducibility;Research;Research Personnel;Resolution;Resources;response;Sampling;Serine;Services;Signal Transduction;Site;Slide;South Carolina;Spatial Distribution;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Stress;success;Sulfonic Acids;System;Technology;therapy resistant;Threonine;Tissue imaging;Tissues;Training;translational study;Treatment Efficacy;Tyrosine;Ubiquitin;United States National Institutes of Health;Update

PROJECT_TITLE: Proteomics Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Dissemination and Implementation Research;Infertility;Pediatric;Prevention;Women's Health Research

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Young adult female cancer survivors who complete gonadotoxic treatment often need to use assisted reproductive technology or adoption to have a child, which have physical/medical, emotional, financial, legal, and logistical challenges. Roadmap to Parenthood is a web-based decision aid and planning tool for family building after cancer and across two pilot studies demonstrated positive effects on decisional conflict, knowledge, self-efficacy, and patient-provider communication. The proposed study will test the efficacy of the ‘Roadmap tool’ to support fertility and family-building decisions and planning behaviors and explore its future implementation potential, thereby ensuring women are prepared and able to have a child if and when they want to after cancer.

PI_NAMEs: SCHAPIRA, LIDIA  (contact)

PROGRAM_OFFICER_NAME: ADAMS, LYNN S

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Adult women;Aftercare;Age;Area;assigned female at birth;Assisted Reproductive Technology;attentional control;Behavior;Behavioral Mechanisms;Behavioral Model;Belief;Cancer Survivor;Cancer Survivorship;cancer therapy;Caring;Categories;Child;Clinic;Clinical;Communication;comparison control;Computer software;Conflict (Psychology);Continuance of life;Control Groups;cost;Counseling;Data;Decision Aid;Decision Making;Distress;efficacy testing;efficacy trial;Emotional;Emotions;Ensure;expectation;experience;Family;family building;Fertility;fertility preservation;Fertilization in Vitro;follow-up;Future;future implementation;Generations;Goals;group intervention;Gynecology;High-Risk Cancer;implementation facilitators;implementation intervention;improved;Infertility;Intervention;intervention effect;Intervention Trial;Interview;Knowledge;Legal;Malignant Neoplasms;Mediating;Mediator;Medical;medical specialties;Mission;Modeling;Motivation;novel;oncofertility;Oncology;Online Systems;Pamphlets;patient-clinician communication;Patients;Pilot Projects;pilot test;preference;Pregnancy;pregnant;Premature Menopause;Primary Care;primary outcome;Provider;provider communication;psychosocial;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;Reporting;reproductive;Reproductive Health;Reproductive Medicine;Research;Resources;Risk;secondary outcome;Self Efficacy;skills;success;surrogacy;Surveys;Survivors;survivorship;Testing;therapy development;Time;tool;Trauma;Treatment Efficacy;United States National Institutes of Health;web based decision aid;Woman;Work;young adult

PROJECT_TITLE: Testing the efficacy of a decision aid and planning tool for family building after cancer

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: LEMASTERS, JOHN J (contact)

PROJECT_TERMS: Address;Animals;Apoptosis;Awareness;Bioenergetics;Biological Sciences;Biology;Biomedical Research;cell fixing;Cell Membrane Permeability;Cell Physiology;Cell Survival;Cells;cellular imaging;Centers of Research Excellence;Clinical;Communities;Computer software;Computer Workstations;Consultations;Data;Data Analyses;Detection;Development;digital imaging;Education;Educational workshop;electrical potential;Electron Microscopy;Ensure;Environment;Equilibrium;Equipment;Equipment and supply inventories;Event;fluorescence microscope;Fluorescence Resonance Energy Transfer;Fluorescent Probes;fluorophore;Freezing;Funding;Funding Mechanisms;Gases;Gene Expression;Generations;Genetic;Grant;high resolution imaging;histological image;histological slides;Histopathology;Human Resources;Image;Image Analysis;image processing;imaging approach;imaging system;Imaging technology;Immersion;immunocytochemistry;Institution;instrument;instrumentation;International;intravital imaging;intravital microscopy;Investigation;Ions;Laboratories;Lasers;Leadership;lectures;Leukocytes;light microscopy;liquid crystal polymer;live cell imaging;Measurement;Medicine;member;Mentors;method development;Methods;Microcirculation;Microscope;microscopic imaging;Microscopy;Mitochondria;Molecular;molecular imaging;Monitor;multi-photon;multiphoton microscopy;multiplexed imaging;Necrosis;next generation;novel;operation;optical imaging;Optics;Organism;Oxidants;Oxidation-Reduction;Paraffin;Pathology;pathology imaging;Permeability;Phase;Preparation;programs;protein distribution;Proteins;pyridine nucleotide;quasar;Reporter;Research;Research Personnel;Research Proposals;Research Support;Resolution;Resources;Running;Scanning;Scanning Electron Microscopy;second harmonic;Series;Services;Signal Transduction;Silicone Oils;skills;Slide;Source;South Carolina;Specimen;Stress;submicron;success;superresolution microscopy;System;targeted imaging;Technology;Temperature;Three-Dimensional Imaging;Tissue imaging;Tissues;tool;Training;Training Activity;Transmission Electron Microscopy;ultra high resolution;United States National Institutes of Health;Visualization;Water;Work

PROJECT_TITLE: Cell and Molecular Imaging Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

PHR: PROJECT NARRATIVE (Project 3) Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive infiltration of immune cells, and in particular, macrophages are abundant in the PDAC stroma, contributing to disease progression as well as resistance to treatment. However, the factors contributing to the immune landscape within the tumor microenvironment (TME) and throughout the host during PDAC development and progression are poorly understood. In this project, we seek to delineate the role of somatic cancer cell alterations, cell type of origin, and tumor molecular subtype in modulating the local and systemic immune profiles during PDAC development, and to investigate the mechanisms by which the immune landscape of the TME and the host are altered in response to therapy that reprograms immunosuppressive tumor-associated macrophages into immunostimulatory antigen-presenting cells.

PI_NAMEs: ENGLEMAN, EDGAR G.  (contact)

PROJECT_TERMS: Affect;Agonist;analytical tool;Antibodies;Antigen-Presenting Cells;antitumor effect;Automobile Driving;Base Composition;Biological Assay;cancer cell;CDKN2A gene;Cell Line;cell type;Cells;cytokine;Data;Development;Disease Progression;DNA Sequence Alteration;driver mutation;Duct (organ) structure;Ductal Epithelial Cell;effective therapy;Environment;Enzyme-Linked Immunosorbent Assay;Exhibits;exome sequencing;Frequencies;Genetic;Genetically Engineered Mouse;Genomics;Genotype;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;high dimensionality;Human;Immune;immune cell infiltrate;immune checkpoint blockade;immune function;Immune response;Immune system;Immunobiology;Immunologics;immunoregulation;Immunotherapy;improved;KRAS2 gene;Lesion;Ligands;Macrophage;MADH4 gene;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Methods;Modeling;Molecular;molecular subtypes;mouse dectin-2;mouse model;Mus;Mutation;mutational status;neoplastic cell;neutralizing antibody;Organism;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;patient population;Pattern recognition receptor;pharmacologic;programs;Property;Quantitative Reverse Transcriptase PCR;receptor;recruit;Resistance;response;Role;Shapes;Signal Pathway;single-cell RNA sequencing;Specimen;System;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapy resistant;TP53 gene;transplant model;Transplantation;Treatment Efficacy;treatment response;tumor;tumor growth;tumor microenvironment;Tumor Promotion;Tumor-associated macrophages;Tumor-Derived;Tumor-infiltrating immune cells;Variant;Work

PROJECT_TITLE: Project 3: Impact of tumor genetics on PDAC immunobiology and responses to macrophage-targeted immunotherapy


NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE  Ribonuclease L (RNase L) is critical for combatting viral infection, yet how it functions remains elusive. The research proposed in this application will define the mechanisms and functions by which RNase L accelerates mRNA decay, reprograms translation, inhibits nuclear mRNA export, and regulates the assembly of innate immune ribonucleoprotein complexes. It will also examine how pathogenic viruses evade and potentially hijack the OAS/RNase L antiviral pathway for their own benefit.

PI_NAMEs: BURKE, JAMES M (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 2019-nCoV;Acceleration;Anti-viral Response;Autoimmune Diseases;Biology;cancer therapy;Cell Nucleus;Cell Physiology;Complex;Cytoplasm;Cytoplasmic Granules;Dengue Infection;Dengue Virus;Development;Disease;Gene Expression;gene induction;Immune;immunoregulation;Influenza A virus;Interferon Type I;Knowledge;Malignant Neoplasms;Mediating;Medicine;Messenger RNA;Molecular;mRNA Decay;mRNA Export;Nerve Degeneration;Nuclear;pathogenic virus;Pathogenicity;Pathway interactions;Process;Production;programs;Protein Biosynthesis;Regulation;Research;response;Ribonucleases;Ribonucleoproteins;Ribosomes;RNA;stress granule;Translations;Viral;Viral Genes;Viral Proteins;virology;Virus;Virus Diseases

PROJECT_TITLE: Understanding the OAS/RNase L pathway during pathogenic viral infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Physical Activity;Prevention

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Sedentary behavior has emerged as an important target for public health interventions, and workplaces are an ideal setting to intervene. This project will test both the effectiveness and implementation of a multicomponent behavioral intervention designed to support the use of sit-stand workstations at work. This project will lead to enhanced knowledge on the role of expert facilitators in workplace interventions and the effectiveness and cost-benefit of sit-stand workstations and an associated intervention for reducing sedentary time.

PI_NAMEs: BUMAN, MATTHEW P (contact);PEREIRA, MARK A

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: Address;Adherence;Adult;arm;Behavior Therapy;Behavioral;Binding;Body Weight;Cardiovascular Diseases;Chronic Disease;Competence;cost;Costs and Benefits;Dimensions;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness trial;effectiveness/implementation hybrid;efficacy trial;Employee;ergonomics;Evidence based intervention;flexibility;follow-up;Government;Health;Health Benefit;Health Promotion;Health Services;implementation cost;implementation facilitation;implementation fidelity;implementation outcomes;implementation questions;implementation strategy;implementation trial;implementation/effectiveness;improved;incremental cost;Industry;innovation;Internet;Intervention;intervention cost;intervention effect;intervention program;Interview;Investments;Knowledge;Maintenance;Malignant Neoplasms;Manufacturer;Measures;mortality;Musculoskeletal Pain;Non-Insulin-Dependent Diabetes Mellitus;Nonprofit Organizations;Occupations;post implementation;preservation;prevent;primary outcome;programs;Promoting Action on Research Implementation in Health Services framework;Public Health;public health intervention;public health priorities;Quality of life;Randomized;randomized trial;Reporting;Research;Risk;Risk Factors;Role;sedentary;sedentary lifestyle;social;Societies;Speed;Testing;therapy design;Time;Translating;treatment arm;trend;trial design;Variant;Vendor;Work;work-study;Workplace

PROJECT_TITLE: Stand & Move at Work II: Effectiveness and Implementation

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


PI_NAMEs: TOWNSEND, DANYELLE M. (contact)

PROJECT_TERMS: Amino Acids;Analytical Biochemistry;antioxidant enzyme;Antioxidants;base;Biochemistry;Bioenergetics;Biological Assay;biological systems;Biology;Centers of Research Excellence;Communities;Complement;Computer software;Consultations;Coupling;design;Detection;Development;Education;Ensure;enzyme activity;Enzyme Kinetics;Enzymes;Equilibrium;Equipment;Event;extracellular;Extravasation;Fatty Acids;Flow Cytometry;Fluorescence Resonance Energy Transfer;Generations;Genus Hippocampus;Glutathione Disulfide;Goals;Grant;Homeostasis;human disease;Human Pathology;Human Resources;in silico;In Situ;Infrastructure;innovation;instrument;interdisciplinary approach;International;Kinetics;Label;Leadership;Manuscripts;Measurement;Measures;Mediating;member;Membrane Proteins;Mentors;Metabolic;Methods;millisecond;Mitochondria;molecular modeling;multidisciplinary;oxidant stress;Oxidants;oxidation;Oxidation-Reduction;Oxygen Consumption;Pathway Analysis;Phase;Phosphorylation;Post-Translational Protein Processing;Process;Protein Analysis;Protein Glycosylation;protein protein interaction;Protein S;Proteins;Proteomics;Protons;Qualitative Methods;Reaction;Research;Research Personnel;Resolution;Resources;Services;Signal Pathway;Signal Transduction;Site;skills;South Carolina;Stress;sugar;Sulfhydryl Compounds;Techniques;Technology;Time;Tissues;Training;Writing

PROJECT_TITLE: Analytic Core


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

PHR: Project Narrative (Core A)  This P01 application from investigators at Stanford University seeks to discover, apply and  translate science about pancreatic cancer (PDAC), with the ultimate goal of improving care for  patients with this disease. To address fundamental, persistent questions about the biology of  PDAC, we have assembled a superb, interactive team of productive collaborators to lead our  Projects and Research Cores. This team will identify genetic and immune cell-based  interactions and pathways that regulate the inception and progression of PDAC. Advances from  studies proposed here could broadly impact pancreas cancer biology, and drive translational  efforts in PDAC.

PI_NAMEs: KIM, SEUNG K (contact)

PROJECT_TERMS: Address;Administrator;Biology;Biostatistics Core;burden of illness;Cancer Biology;career development;Cells;Collaborations;Communication;Communities;Consultations;Dedications;Development;Disease;Education;Ensure;Environment;Faculty;Genetic;Goals;graduate student;Human Resources;Immune;immunoregulation;improved;Knowledge;Lead;Maintenance;Malignant neoplasm of pancreas;Medical Students;member;operation;Pathway interactions;Patient Care;Postdoctoral Fellow;Productivity;programs;Public Health;Research;Research Personnel;Resource Sharing;Resources;Role;Science;statistics;Training and Education;Translating;Universities;web site

PROJECT_TITLE: Administrative and Biostatistics Core


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

PHR: PROJECT NARRATIVE This study will create an assessment to better understand the readiness of unpaid caregivers to engage in caregiving activities after care recipients’ hospital discharge, and will test whether caregiver readiness is associated with patient and caregiver outcomes during their high-risk transitions from hospital to home. Results of this study will provide much needed information regarding the role of caregiver readiness in the outcomes of hospitalized patients, health systems with a way to assess the quality of discharge preparation offered to caregivers, and a means of evaluating caregiver-focused hospital discharge interventions over time and across systems.

PI_NAMEs: BRISTOL, ALYCIA A;WALLACE, ANDREA SCHNEIDER (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Uncovering Caregiver Discharge Readiness for Patient Care Transitions from Hospital to Home: The UCare Study

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences;Pediatric

PHR: Human research applications of brain Positron Emission Tomography (PET) imaging have been in place for over 40 years and have led to a detailed understand of normal brain physiology including neurotransmitter dynamics and receptor pharmacology at rest and during activation. Brain-dedicated PET systems offer important advantages over currently available PET systems, but the state-of-the-art for brain PET imaging systems has not progressed beyond the 20-year-old HRRT. The proposed next generation NeuroEXPLORER (NX) PET system will have a factor of 10 greater sensitivity and will dramatically expand the scope of human brain PET protocols and applications.

PI_NAMEs: CARSON, RICHARD E. (contact);LI, HONGDI ;QI, JINYI

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: 20 year old;Adolescent;algorithm development;Algorithms;Area;attenuation;Blood;Body System;Brain;brain health;Brain imaging;Brain scan;Carotid Arteries;Cell Nucleus;Child;Clinical;Collaborations;Data;data quality;Dedications;density;design;Detection;detector;Development;Disease;Dopamine;Dose;Effectiveness;Enzymes;Evaluation;experience;experimental study;frontier;Functional disorder;Future;Geometry;Goals;Healthcare;Hippocampus;Human;human subject;Image;imager;imaging system;improved;in vivo imaging;Inferior;kinetic model;Length;locus ceruleus structure;Machine Learning;Manufacturer;Marketing;Measures;Metabolism;Methods;Midbrain structure;Modeling;Motion;Nerve Degeneration;neurochemistry;neurotransmitter release;Neurotransmitters;next generation;Noise;novel;operation;Opioid;Performance;pharmacologic;Pharmacology;Physics;Physiology;Positron-Emission Tomography;pre-clinical;Proteins;Protocols documentation;Radioactive;radiotracer;raphe nuclei;receptor;reconstruction;Research;Resolution;Rest;Sampling;Sensory Receptors;Shapes;solid state;statistics;Structure;Substantia nigra structure;Synapses;System;Technology;Testing;Thalamic structure;Time;Tracer;ultra high resolution;uptake;X-Ray Computed Tomography

PROJECT_TITLE: NeuroExplorer: Ultra-high Performance Human Brain PET Imager for Highly-resolved In Vivo Imaging of Neurochemistry


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE: Stanford Human Bio-bank for Pancreas Cancer Research (Core B) The Stanford Human Bio-Bank for Pancreas Cancer Research is a proposed Core to support the research projects in this Program Project Grant focused on genetic and immune regulation of pancreatic cancer development. This core will systematically collect and bank human tissues and blood from patients with pancreatic cancer and pre-cancerous conditions including chronic pancreatitis. These samples will support human tissue and cell studies that are part of the integrated research projects and support an innovative CO- Detection by indEXing (CODEX)-based multi-parameter imaging Core. In addition to banking bio-specimens, this Core will provide expertise and knowledge of human tissue analysis by histology, immunohistochemistry, and other advanced analytical techniques. This research core will help this Program meet the public health goals of the NCI by providing a translational platform to develop and validate biomarkers for early diagnosis and treatment of pancreatic cancer.

PI_NAMEs: PARK, WALTER GWANG-UP (contact)

PROJECT_TERMS: advanced analytics;anti-cancer research;biobank;Biological Response Modifiers;Biological Specimen Banks;biomarker validation;Blood;Blood specimen;cancer subtypes;Cells;chronic pancreatitis;Clinical;Collaborations;Detection;Development;Disease;Ductal Epithelial Cell;Early Diagnosis;Early treatment;Evaluation;Fibroblasts;Genetic;Genetic Variation;Genetically Engineered Mouse;Genotype;Goals;health goals;Histology;Human;human data;human tissue;Image;Immune;Immune system;Immunohistochemistry;immunoregulation;indexing;Inflammatory;innovation;interleukin-22;Knowledge;KRAS2 gene;laser capture microdissection;Lesion;Malignant neoplasm of pancreas;Malignant Neoplasms;Metaplasia;Mus;novel;Oncogenes;Pancreas;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pancreatic Intraepithelial Neoplasia;Pathogenesis;Patients;Pattern;Phenotype;Precancerous Conditions;premalignant;Process;Program Research Project Grants;programs;Public Health;Registries;Research;Research Project Grants;Research Support;Role;sample collection;Sampling;single-cell RNA sequencing;specific biomarkers;stemness;Techniques;Testing;tissue processing;Tissues;Translating;Tumor Suppressor Genes;Work

PROJECT_TITLE: Core B: Human Pancreas


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research

PI_NAMEs: EBLEN, SCOTT T (contact)

PROJECT_TERMS: Address;Applications Grants;Area;Award;base;Biology;Biomedical Research;Categories;Centers of Research Excellence;Clinical;Clinical Research;Collaborations;Communities;Core Facility;Data;design;Development;Discipline;Electronics;Elements;Eligibility Determination;Equilibrium;Extramural Activities;Faculty;feasibility testing;Feedback;Financial Support;Fostering;Funding;Future;Goals;Grant;human disease;improved;informatics tool;Infrastructure;innovation;Interdisciplinary Study;Laboratory Research;Letters;Medical;meetings;member;Mentorship;Metabolism;Mission;Modeling;novel;online resource;Oxidants;Oxidation-Reduction;Peer Review;Phase;Pilot Projects;Preparation;Process;programs;Progress Reports;Qualifying;Request for Applications;Research;Research Personnel;Research Project Grants;Resources;Scholarship;Scientific Evaluation;screening;Secure;Signal Transduction;South Carolina;Stress;System;Technology;Testing;Training;Translational Research;translational study;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Pilot Projects Program


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Overall - Project Narrative This core grant facilitates the research programs of scientists studying vision at the University of Pennsylvania. These scientists conduct research that reveals the mechanisms of healthy vision, characterizes how disease affects these mechanisms, and uses the insights gained from the basic research to develop sight-saving and sight-restoring treatments. Because it provides support for the entire research chain, this core grant contributes to public health by helping to reduce vision loss.

PI_NAMEs: MITCHELL, CLAIRE H (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Affect;Animal Model;awake;Basic Science;Bioinformatics;Biometry;Blindness;Cellular biology;Clinical Research;cognitive neuroscience;Collaborations;Computer Models;Confocal Microscopy;Core Grant;Custom;Data;data acquisition;Data Analyses;data curation;design and construction;Disease;Electrophysiology (science);Equipment;Experimental Designs;Eye;gene therapy;Goals;Grant;Image;imaging modality;In Vitro;insight;instrument;instrumentation;Maintenance;Molecular Biology;Molecular Genetics;multi-electrode arrays;National Eye Institute;novel;Pennsylvania;Physiology;Primates;programs;Public Health;Qualifying;recruit;repaired;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Retina;Retinal Degeneration;Scientist;Services;sight restoration;skills;Software Tools;Source;Stimulus;Tissues;two-photon;Universities;Vision;Vision research;Visual Cortex;Visual impairment;Visual Pathways;visual performance;Visual Psychophysics

PROJECT_TITLE: P30 Core Grant for Vision Research


ORG_CITY: DAVIS

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Imbalanced protein homeostasis (proteostasis) disrupts protein clearance and increases abnormal deposition of protein aggregates which facilitates cancer cell survival and progression. HSP70 protects oncogenic protein degradation from STUB1 in anti-androgen resistant prostate cancer. This proposal will develop novel HSP70/STUB1 modulators to overcome the therapeutic resistance.

PI_NAMEs: LIU, CHENGFEI  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: abiraterone;Acetates;Address;American;analog;Androgen Antagonists;androgen independent prostate cancer;Androgen Receptor;Androgens;Animal Model;Anthelmintics;Anti-androgen Therapy;Antibodies;Binding Sites;Biodistribution;Biological Assay;Biological Availability;Blood;Bypass;Calorimetry;cancer cell;Cancer Patient;cancer therapy;Cell Culture Techniques;Cell model;Cell Survival;Cells;Characteristics;Chronic;Clinic;Clinical;Clinical Trials;clinically relevant;Co-Immunoprecipitations;Complex;Data;Deposition;Development;Diagnosis;Disease;Disease Resistance;Drug Kinetics;Drug resistance;Drug usage;effective therapy;enzalutamide;Enzymes;Flow Cytometry;Future;Goals;Half-Life;Heat-Shock Proteins 70;Immunocompetent;Immunofluorescence Immunologic;improved;In Vitro;in vivo;Label;Ligation;liquid chromatography mass spectrometry;Longevity;Luciferases;Lysine;male;Malignant neoplasm of prostate;Malignant Neoplasms;men;Molecular Chaperones;Molecular Target;mouse model;multicatalytic endopeptidase complex;MYC Family Protein;next generation;novel;Oncogenic;Oral;Organoids;Outcome;Parasitic infection;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Post-Translational Protein Processing;Precipitation;Primary Neoplasm;Property;prostate cancer cell;Prostatic Neoplasms;protein aggregation;protein degradation;Proteins;proteostasis;Quality of life;Reagent;receptor;Receptor Signaling;Regulation;Reporter;Research Personnel;Resistance;resistance mechanism;small molecule;Sprague-Dawley Rats;Stains;success;Surface Plasmon Resonance;System;Technology;Testing;Testosterone;Therapeutic;therapy resistant;Time;Titrations;Toxic effect;Translating;Translations;tumor;tumor progression;Tumor-Derived;Ubiquitin;Ubiquitin-mediated Proteolysis Pathway;ubiquitin-protein ligase;Ubiquitination;United States Food and Drug Administration;Variant

PROJECT_TITLE: Modulating HSP70/STUB1 machinery in therapy-resistant prostate cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


PHR: PROJECT NARRATIVE (Core C) In order to understand the roles of specific types of cells, including immune cells, in pancreatic cancer, this core  will use a new method developed at Stanford called Co-Detection by indexing (CODEX), which enables us to  define the frequency, spatial relationships and activation states of cell types within tumors, and to learn how  these parameters change over time and in response to treatment. This core will work closely with all 3 projects  to support their studies of mouse and human tissues, thereby helping this Program to meet the public health  goals of the NCI by discovering biomarkers that enable early diagnosis and more effective treatment for cancer.

PROJECT_TERMS: Antibodies;Antigens;Architecture;Biological Markers;cancer cell;cancer therapy;candidate identification;Cell Ontogeny;cell type;Cells;Cellular Structures;Consultations;cost;Data;Detection;Development;Disease;Early Diagnosis;effective therapy;Ensure;Epithelium;Frequencies;Generations;Genetic;Goals;health goals;Human;Human Resources;human tissue;Image;Immune;Immune Evasion;Immune system;immunoregulation;in vivo;indexing;Individual;Laboratories;Learning;Link;Malignant neoplasm of pancreas;Maps;Methods;Monitor;mouse model;Mus;Neighborhoods;Pancreas;pancreas imaging;Population;programs;Public Health;Quality Control;Reagent;Research;Research Personnel;Resources;Retrieval;Role;Services;Signal Transduction;single-cell RNA sequencing;spatial relationship;Stains;stem cells;Stereotyping;Time;Tissue imaging;tissue preparation;Tissue Procurements;Tissues;tool;treatment response;tumor;tumor growth;ultrasound;Work

PROJECT_TITLE: Core C: CODEX Core


ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative Cells are living in a complex chemical environment. Understanding the cellular response to the local environment is crucial in many physiological processes. The proposed projects will develop precision delivery tools to quantitatively control the microenvironment at the single-cell level for fundamental biological studies, including neuron transmission and immune response.

PI_NAMEs: REN, HANG  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: analytical tool;Biological;Biological Process;Blood coagulation;Cells;Chemicals;Complex;digital delivery;Disease;Electrodes;Environment;Generations;Health;Heterogeneity;Human;Imaging Techniques;Immune response;In Situ;Inflammatory Response;interest;Investigation;Ions;Location;Maps;Methods;Modality;nano;nanoparticle;nanoscale;Neurons;neurotransmission;Nitric Oxide;Physiologic pulse;Physiological;Physiological Processes;Proteins;Reactive Nitrogen Species;Reactive Oxygen Species;Research;response;single cell analysis;Spatial Distribution;Stimulus;System;temporal measurement;tool;uptake;Vesicle

PROJECT_TITLE: Spatially and Temporarily Resolved Precision Delivery for Quantitative Biological Studies


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: BRAINARD, DAVID H. (contact)

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

PI_NAMEs: YING, GUI-SHUANG  (contact)

PROJECT_TERMS: Accounting;Age related macular degeneration;Applications Grants;Bioinformatics;Biometry;Biostatistics Core;Collaborations;computer program;Computer software;Consultations;Core Grant;Custom;Data;Data Analyses;Data Correlations;data management;Database Management Systems;Databases;Development;Disadvantaged;Dry Eye Syndromes;Epidemiology;Experimental Designs;experimental study;Eye;Glaucoma;Graph;health data;Healthcare;Healthcare Systems;Human Resources;Image;indexing;Manuscripts;Measurement;Measures;member;Methodology;Methods;Myopia;ocular imaging;Participant;patient oriented research;Refractive Errors;Research Design;Research Personnel;Resources;Retina;retina blood vessel structure;Retinopathy of Prematurity;Sample Size;Scientist;Statistical Data Interpretation;Technical Expertise;Techniques;Thick;Uveitis;Vision;Vision research;Visual Acuity;Visual Fields;Width;Writing

PROJECT_TITLE: Biostatistics Module


PROJECT_TERMS: Canis familiaris;Core Grant;Electrophysiology (science);Goals;Human Resources;Image;imaging capabilities;Imaging Device;imaging facilities;imaging system;In Vitro;in vivo;instrument;member;Microscope;multi-electrode arrays;multidisciplinary;patch clamp;Pathologic;Research Personnel;Resource Sharing;Resources;Retina;retinal imaging;Structure;Training;two-photon;Vision;Vision research;Visual System;Work

PROJECT_TITLE: Imaging and Electrophysiology


ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE The Fred & Pamela Buffett Cancer Center (BCC), the only NCI-designated cancer center in Nebraska, is a matrix cancer center at the University of Nebraska Medical Center and our affiliated healthcare network, Nebraska Medicine. The Mission of the BCC is to promote innovative translational cancer research, excellence in cancer education and training, and outstanding patient-centered cancer care and to reduce the burden of cancer and cancer health disparities across Nebraska and beyond.

PI_NAMEs: SWEASY, JOANN B. (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Address;anti-cancer research;Award;Basic Science;Biological Markers;Cancer Biology;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;cancer health disparity;cancer initiation;Catchment Area;Clinical;Clinical Cancer Center;clinical care;Clinical Research;Clinical Sciences;Clinical Trials;Communities;community engagement;Community Outreach;community partners;computational chemistry;Development;Direct Costs;Early Diagnosis;Education;Environment;Fostering;Funding;Health care facility;health disparity;Healthcare;innovation;interdisciplinary collaboration;Intervention;Leadership;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Medical center;Medicine;member;metabolomics;Mission;Modeling;multidisciplinary;Names;NCI-Designated Cancer Center;Nebraska;novel therapeutic intervention;Organoids;outreach;patient oriented;Patients;Pharmaceutical Chemistry;Physicians;Population Sciences;Positioning Attribute;preclinical imaging;Prevention;Prognosis;programs;recruit;Reporting;Research;research facility;Research Infrastructure;Research Peer Review;Research Support;Resource Sharing;Resources;Risk;Role;Scientific Advances and Accomplishments;Synthesis Chemistry;Teacher Professional Development;Tissue Microarray;Training and Education;translational cancer research;Translational Research;tumor progression;underserved community;Universities

PROJECT_TITLE: Buffett Cancer Center Support Grant

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision

PI_NAMEs: BELTRAN, WILLIAM A. (contact)

PROJECT_TITLE: Instrumentation Module


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: AGUIRRE, GEOFFREY KARL (contact)

PROJECT_TERMS: Algorithmic Analysis;analysis pipeline;Anatomy;Area Analyses;Biometry;Brain;Brain imaging;Cell Density;cloud based;Code;Communities;Computer Hardware;Computer software;Consultations;Core Grant;cost;Custom;Data;Data Analyses;data analysis pipeline;Data Analytics;data curation;Data Storage and Retrieval;Dependence;Derivation procedure;Development;Elements;empowerment;experience;Fiber;Funding;Future;Grant;Human Resources;Image;Image Analysis;image reconstruction;image registration;Informatics;innovation;instrument;Measurement;Metadata;Methods;next generation;novel;open source;Operating System;Optics;Pathway interactions;Pennsylvania;Policies;quantitative imaging;Radiation;Reproducibility;Reproducibility of Results;Research;Research Personnel;Research Technics;Retina;retinal imaging;retinotopic;Services;Software Tools;support tools;System;tool;United States National Institutes of Health;Universities;virtual;Vision;Vision research;vision science;Visual Pathways

PROJECT_TITLE: Scientific Transparency


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: DETROIT

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Name of Applicant (Last, first, middle): Berkowitz, Bruce A. The proposed research is relevant to public health because aging patients remain vulnerable to the devastating dementia associated with Alzheimer’s disease, a disease without any treatment options to prevent or delay its trajectory. Accumulating evidence highlights hyperactive neurons in its very beginning stages as an important driver of Alzheimer’s disease. Here, we propose new imaging biomarkers of hyperactive neurons in the retina, the most accessible part of the nervous system, to enable very early evaluation of treatment efficacy in patients at risk for Alzheimer’s disease.

PI_NAMEs: BERKOWITZ, BRUCE A. (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Age;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Appearance;Biological Assay;Biological Markers;biomarker driven;biomarker signature;Brain;Calcium Channel;Cognition;Contrast Sensitivity;crosslink;Dementia;Deposition;Disease;Drug Targeting;Drug usage;Electron Transport Complex III;Endoplasmic Reticulum;Evaluation;Excision;experience;falls;Female;Functional disorder;Glutamates;Goals;Hippocampus;Hyperactivity;imaging biomarker;Impaired cognition;Impairment;In Situ;indexing;Individual;Laboratories;Learning;Left;Light;Link;male;Measures;Memory impairment;Memory Loss;Methods;mild cognitive impairment;Mitochondria;Morbidity - disease rate;Mus;Names;Nervous System;Neurofibrillary Tangles;Neurons;novel;Optical Coherence Tomography;Patients;Pharmaceutical Preparations;Photoreceptors;Prediction of Response to Therapy;prevent;Proxy;Public Health;rate of change;Reporting;Research;Resolution;response;Retina;retinal imaging;Risk Factors;Rod;Ryanodine Receptor Calcium Release Channel;Senile Plaques;spatial memory;Synapses;tau-1;Testing;Text;Therapeutic;Time;Treatment Efficacy;Water;Whole-Cell Recordings;Wild Type Mouse

PROJECT_TITLE: Novel Early Retinal Imaging Biomarkers for Treating Later Spatial Memory Loss in Experimental Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: WINFREY, MATTHEW  (contact)

PROJECT_TERMS: anti-cancer research;Area;Award;Basic Science;Budgets;Businesses;Cancer Center;Cancer Center Support Grant;cancer research center director;Case Management;Clinical Cancer Center;Clinical Research;Clinical Trials;Collaborations;Communication;Contracts;Core Facility;Data;data management;Data Management Resources;Documentation;Education;Ensure;Equipment;Evaluation;Faculty;faculty support;Financial Support;Funding;Grant;Guidelines;Human Resources;improved;Individual;Information Technology;Institution;Leadership;Maintenance;Malignant Neoplasms;Medicine;meetings;member;Monitor;NCI Center for Cancer Research;Nebraska;Notification;operation;Philanthropic Fund;Pilot Projects;Positioning Attribute;Process;programs;Public Relations;Publications;recruit;Reporting;Research;Research Activity;research and development;Research Personnel;Resource Sharing;Services;Strategic Planning;symposium;System;University Hospitals

PROJECT_TITLE: Cancer Center Administration


NIH_SPENDING_CATS: Cancer;Pediatric;Rural Health

PI_NAMEs: SOLHEIM, JOYCE C (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;African;anti-cancer research;Applications Grants;Area;Automobile Driving;Award;Bioinformatics;Biological Products;Biology;Biometry;Black race;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer education;cancer prevention;Cancer Research Project;cancer therapy;career development;Catchment Area;Centers of Research Excellence;Clinical;Collaborations;college;Committee Members;Communities;Comprehension;Continuing Education;cooking;Counseling;Country;Dedications;design;Development;disadvantaged student;Education;Education Projects;education research;Educational process of instructing;Educational workshop;Ensure;Evaluation;Event;experience;Faculty;Funding;Future;Goals;Grant;Health;Health Professional;high school;High School Student;improved;Individual;Industry;insight;Institution;International;junior high school;Knowledge;Laboratories;Leadership;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Medical center;medical specialties;medically underserved population;member;Mentors;mindfulness;Minority Groups;Mission;Native Americans;NCI Center for Cancer Research;Nebraska;notch protein;Nurse Practitioners;Oncologist;outreach;Positioning Attribute;Postdoctoral Fellow;Preparation;Process;Program Appropriateness;programs;recruit;Reproducibility;Research;Research Personnel;Research Training;Resources;Role;Rural;Rural Population;Schools;Screening for cancer;senior faculty;skills;Students;symposium;Teacher Professional Development;Training;Training and Education;Training Programs;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;virus related cancer;Visit

PROJECT_TITLE: Cancer Research Training and Education Coordination


ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: NARRATIVE The FIRST Cohort Program at the Icahn School of Medicine at Mount Sinai (ISMMS) will integrate development of a Roadmap for Inclusive Excellence strategic plan, a Cohort/cluster model of recruitment of a diverse cohort of early-career faculty committed to diversity and inclusive excellence, and a robust program of faculty development. The program’s goals are to effect sustainable culture change at our institution and to support the FIRST Cohort faculty hires in obtaining extramural funding.

PI_NAMEs: BENN, EMMA KATHERINE TARA (contact);CAMPBELL, KIRK N;NESTLER, ERIC J.;RICHARDSON, LYNNE D.

PROJECT_TERMS: Acceleration;Address;Advisory Committees;anti-racism;Appointment;Award;Biomedical Research;Black race;career;career development;Career Mobility;Climate;climate change;cohort;Collaborations;Committee Members;Communities;community building;Data;design;Development;Development Plans;Discrimination;diversity and inclusion;early-career faculty;Educational workshop;Ensure;Equity;Evaluation;expectation;experience;Extramural Activities;Faculty;faculty support;Financial compensation;Fostering;Funding;gender equity;Goals;Grant;Health equity research;Health system;Individual;Institution;interest;Intervention;Interview;Investments;Job Application;Latinx;Leadership;Life;marginalization;medical schools;Medicine;member;Mentors;Modeling;novel;outreach;peer coaching;Personal Satisfaction;Policies;Positioning Attribute;primary outcome;Process;professor;Program Development;Program Evaluation;programs;Protocols documentation;racism;recruit;Research;Research Support;Secure;skill acquisition;Standardization;statistics;Strategic Planning;success;Surveys;Teacher Professional Development;tenure track;Training;unconscious bias;Underrepresented Populations;United States National Institutes of Health;Work

PROJECT_TITLE: NIH FIRST Cohort Cluster Hiring Initiative at Icahn School of Medicine at Mount Sinai


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Aging;Bioengineering;Eye Disease and Disorders of Vision;Nanotechnology;Neurodegenerative;Neurosciences

ORG_CITY: FORT WORTH

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

PHR: Glaucoma is a blinding disease associated with elevated eye pressure, progressive death of retinal ganglion cells (RGCs) and is estimated that, over 76 million people will be affected by 2020. Nitric oxide, a small gaseous molecule known to act as a key player in relaxing the trabecular meshwork (TM) cells in eye and has potential to reduce eye pressure, however, free radicals generated during the disease pathology deplete the nitric oxide bioavailability as well as responsible for both TM cells and RGCs death. Our group is working on discovering such multi-functional hybrid small molecules which will decrease eye pressure and protect TM cells as well as RGCs from free radical induced death with potential to be used for treatment of glaucoma.

PI_NAMEs: ACHARYA, SUCHISMITA  (contact);STANKOWSKA, DOROTA LUIZA

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: 3-nitrotyrosine;Address;Adult;Affect;African Green Monkey;Aftercare;age related decline;Allergic Reaction;alpha 2 agonist;Animal Model;Anterior;antioxidant enzyme;Antioxidants;Apoptotic;aqueous;Aqueous Humor;axonal degeneration;Bilateral;Biochemical;Biological Availability;blind;Blindness;Brimodine;Cell Death;Cell Survival;Cells;Cessation of life;Characteristics;Chronic;Clinical;Clinical Trials;Collaborations;Corneal Diseases;Cytoprotection;delivery vehicle;Disease;Dose;Drug Kinetics;drug release profile;efficacy evaluation;Electroretinography;Encapsulated;Esters;Extracellular Matrix;Eye;Eye diseases;Eyedrops;FDA approved;Formulation;Free Radicals;Frequencies;functional group;Future;Gene Expression;Glaucoma;Global Change;Goals;Homeostasis;Human;Hybrids;Hypoxia;in vivo;Injury;intravitreal injection;Lasers;Latanoprost;Lipid Peroxidation;Measures;Mediating;Methods;mimetics;Modeling;Monkeys;mouse model;Mus;nanoparticle;nanoparticle drug;nanopolymer;Nature;Nerve Crush;Neurodegenerative Disorders;neuroprotection;Nitrates;Nitric Oxide;Nitric Oxide Donors;normotensive;novel;novel therapeutics;Ocular Hypertension;Optic Nerve;Optical Coherence Tomography;Pathology;Pathway interactions;patient population;Patients;Pattern;Persons;Physiologic Intraocular Pressure;Posterior eyeball segment structure;Predisposition;preservation;pressure;Prevalence;prevent;Primary Open Angle Glaucoma;Production;Rattus;Reactive Oxygen Species;Regulation;Relaxation;Retina;retinal ganglion cell degeneration;Retinal Ganglion Cells;retinal toxicity;Rodent;Rodent Model;Route;Safety;safety assessment;side effect;small molecule;stem;Sulfhydryl Compounds;Suspensions;Synthetic Prostaglandins;System;Testing;Therapeutic;Tissues;Topical application;Toxicokinetics;Trabecular meshwork structure;transcriptome sequencing;Transforming Growth Factor beta;Traumatic injury;treatment effect;Venous Pressure level

PROJECT_TITLE: Novel hybrid molecule with both IOP lowering and neuroprotective effects for treatment of glaucoma

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


PI_NAMEs: BENN, EMMA KATHERINE TARA (contact)

PROJECT_TERMS: Award;Biomedical Research;Brain;Budgets;career development;climate data;cohort;Collaborations;Communicable Diseases;Communication;community building;Data;Dedications;design;Development;diversity and inclusion;emerging pathogen;empowerment;Ensure;Equity;Evaluation;evidence base;executive function;Faculty;Feedback;Fostering;Funding;global health;Goals;Health equity research;Human Resources;innovation;Institution;Leadership;Link;Malignant Neoplasms;medical schools;meetings;Microbiology;Mission;Monitor;National Cancer Institute;organizational climate;Process;Productivity;programs;recruit;Reporting;Research;research and development;Research Personnel;Research Support;Resource Sharing;Resources;Scientist;Strategic Planning;success;Surveys;Teacher Professional Development;U-Series Cooperative Agreements;Underrepresented Populations;United States National Institutes of Health;web site


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE This study will represent Patient Centered Outcomes Research (PCOR) clinical evidence for imaging using national data standards (e.g., Clinical Quality Language) for clinical decision support (CDS), validate the CDS artifacts, and scale them for dissemination and assessment of interoperability in a different institution than that where the CDS artifacts were developed.

PI_NAMEs: LACSON, RONILDA  (contact)

PROGRAM_OFFICER_NAME: TERAN, MARIO

PROJECT_TITLE: Clinical Decision Support for Disseminating and Implementing Patient-Centered Outcomes Research (PCOR) Clinical Evidence

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


PI_NAMEs: BAND, HAMID  (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Alcohols;Animal Cancer Model;Animals;Area;Atomic Force Microscopy;Biochemical;Biological Markers;Biology;Body System;Cachexia;Cancer Biology;Cancer Cachexia;cancer care;cancer cell;Cancer Center;Cancer Center Support Grant;cancer diagnosis;Cancer Fatigue;cancer genome;cancer initiation;Cancer Model;Cancer Patient;cancer risk;Catchment Area;Cell model;Cells;Cessation of life;chemotherapy;clinical translation;Collaborations;Communication;Crystallography;design;Development;Direct Costs;DNA Damage;DNA metabolism;DNA Repair;DNA Sequence Alteration;Education;Employment;Ensure;Epigenetic Process;epigenome;Etiology;Evaluation;Faculty Recruitment;Fatigue;female fertility;fertility preservation;Foundations;Functional disorder;Funding;Genetic;genetic approach;Genetic Models;Genome;Genome Stability;genome-wide;Genomic Instability;Goals;Grant;improved outcome;Inherited;inhibitor;insight;inter-institutional;interest;International;Intervention;Maintenance;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mammalian Cell;Mammalian Genetics;Mass Spectrum Analysis;meetings;member;Metabolic;metabolic abnormality assessment;Metabolic Pathway;metabolomics;Mission;Molecular;Molecular Target;Morbidity - disease rate;mortality;multicatalytic endopeptidase complex;multidisciplinary;Neoplasm Metastasis;neoplastic cell;next generation;next generation sequencing;novel;Oncogenes;Organ;Oxidation-Reduction;Pathway interactions;Patients;Peer Review;Phenotype;Physiology;Pilot Projects;posttranscriptional;Prevention;Process;programs;Publications;receptor;Receptor Signaling;repaired;Reporting;Research;Research Personnel;Resource Sharing;response;Role;Signal Pathway;Signal Transduction;Symptoms;System;Therapeutic;trafficking;transcriptomics;translational study;Translations;tumor;Tumor Burden;tumor metabolism;tumor microenvironment;tumor progression;tumorigenesis;Ubiquitin;Universities;Validation;Vision;working group;yeast genetics

PROJECT_TITLE: Cancer Biology Program


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Teleophthalmology using retinal cameras in primary care clinics has been shown to improve diabetic eye screening rates and visual outcomes, but remains greatly underutilized in the U.S. This multi-center randomized controlled trial proposes to test the effectiveness and generalizability of a promising implementation program (I- SITE: Implementation to Sustain Impact in Teleophthalmology) for sustaining increased diabetic eye screening rates using teleophthalmology in rural health systems. This research seeks to identify methods for successful integration of telemedicine technology into rural primary care workflows to prevent blindness from diabetes, the leading cause of blindness among working-age U.S. adults.

PI_NAMEs: LIU, YAO  (contact)

PROGRAM_OFFICER_NAME: LE, JIMMY TOAN

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Adherence;Adult;Affect;Age;American;Area;Blindness;care providers;Caring;clinical practice;Clinical Trials;Cluster randomized trial;Communities;Data;design;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Early Diagnosis;Early treatment;Effectiveness;effectiveness evaluation;effectiveness testing;Elements;evidence base;Eye;Face;Future;Goals;Guidelines;Health Services Accessibility;Health system;Health Technology;Healthcare Systems;Human Resources;implementation cost;implementation evaluation;implementation measures;improved;insight;Insurance Coverage;Interview;K-Series Research Career Programs;Knowledge;Measures;meetings;Mentored Patient-Oriented Research Career Development Award;Methods;National Eye Institute;Outcome;Outcome Measure;Patients;pilot test;Prevalence;prevent;Primary Care;primary care clinic;primary care provider;Primary Health Care;primary outcome;programs;Public Health;Randomized, Controlled Trials;Recording of previous events;Research;Retina;Retinal Diseases;Risk;Risk Reduction;Rural;rural Americans;Rural Community;Rural Health;rural patients;Rural Population;scale up;screening;Screening Result;secondary outcome;Strategic Planning;Structure;Technology;telehealth;Telemedicine;teleophthalmology;Testing;Time;Translating;Translations;Travel;treatment as usual;United States National Institutes of Health;Urban Population;urban underserved;Vision;Visual;Visual impairment;Work

PROJECT_TITLE: I-TRUST: Implementation of Teleophthalmology in Rural Health Systems Study


ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE: OVERALL Lower grade (World Health Organization (WHO) grade II/III) glioma (LGG), a malignant tumor of the brain, is a uniformly fatal disease of young adults for which the optimal clinical management remains unknown. A comprehensive genomic characterization of the evolution from primary LGG to recurrence is required to begin to address the LGG knowledge gap. As optimizing the engagement of LGG patients in this effort is critical to the success of this process, we will use our International Low Grade Glioma Registry as a starting point to development methods to engage and construct a community of 700 LGG patients who have undergone surgical resection at time of diagnosis and at time of recurrence and want to participate in research.

PI_NAMEs: CLAUS, ELIZABETH B. (contact);KWAN, BETHANY MATTHEWS;VERHAAK, ROEL GW

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Address;Adopted;Affect;Age;Aneuploidy;Authorization documentation;Automobile Driving;Brain Neoplasms;Cancer Etiology;Caring;CDKN2A gene;Cells;Characteristics;Client satisfaction;Clinical;Clinical Management;Clinical Trials;cloud based;cohort;Collaborations;Communication;Communities;Data;data sharing;design;Diagnosis;Disease;dynamical evolution;Education;effective therapy;Enrollment;Ethics;European ancestry;Evolution;Excision;follow-up;Genetic;Genome;Genomics;Germ Lines;Glioma;Goals;handheld mobile device;health data;Hospitals;improved;improved outcome;Individual;innovation;International;Internet;iterative design;Knowledge;Location;longitudinal analysis;Longitudinal cohort;Malignant neoplasm of brain;Measures;Medical Records;method development;Methods;Modeling;Molecular Evolution;Movement;Mutation;Operative Surgical Procedures;optimal treatments;Outcome;outreach;Participant;Pathology Report;patient engagement;patient privacy;Patient-Focused Outcomes;Patients;Personal Health Records;Persons;Population;Process;Protocols documentation;Qualifying;Questionnaires;Radiation therapy;Radiation Tolerance;recruit;Recurrence;Registries;Reporting;Research;Research Personnel;Research Priority;Resistance;Resources;response;rural setting;Sampling;Secure;social;social media;Socioeconomic Status;software development;Software Tools;success;Technology;temozolomide;Testing;The Cancer Genome Atlas;theories;Time;Translating;treatment response;Trust;tumor;wearable device;willingness;World Health Organization;young adult

PROJECT_TITLE: OPTimIzing engageMent in discovery of molecular evolution of low grade glioma (OPTIMUM)


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: CHEN, BENJAMIN K (contact)

PROJECT_TERMS: Address;anti-racism;Applications Grants;Biomedical Research;career;career development;career life balance;Career Mobility;Climate;Clinical;cohort;Communities;community building;cultural competence;curriculum enhancement;design;Development;Development Plans;Discrimination;early-career faculty;Educational workshop;Ethnic Population;Evaluation;experience;Extramural Activities;Faculty;faculty research;faculty support;Funding;Goals;Grant;Health system;improved;Individual;Institution;Knowledge;Manuscripts;medical schools;Medicine;member;Mentors;Mentorship;Modeling;parity;peer coaching;Personal Satisfaction;Population;Preparation;Productivity;programs;Publications;racial population;racism;Research;Research Support;Resources;satisfaction;Scholars Program;Science;Secure;Series;skill acquisition;skills;Social support;STEM field;STEM research;success;Teacher Professional Development;Testing;Training;Training Programs;unconscious bias;Underrepresented Populations;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: Faculty Development Core


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: Frontotemporal dementia (FTD, also known as frontotemporal lobar dementia or FTLD) is an age-related non-Alzheimer dementia characterized by progressive degeneration of cortical neurons in the frontal and temporal lobes, which share a wide spectrum of clinical, pathological and genetic features with amyotrophic lateral sclerosis (ALS). A subset of FTD is defined by the pathology of protein inclusions containing Fused in Sarcoma (FUS), namely FUS FTD that is caused by pathogenic FUS mutations. This project is to determine the mechanisms how pathogenic FUS interferes with RNA surveillance and turnover, disrupts protein translation, and induces downstream cellular toxicity in cortical neurons in FTD using in vitro and animal models as well as FTD patient tissues.

PI_NAMEs: ZHU, HAINING  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Acetylation;Affect;Age;age related;Amyotrophic Lateral Sclerosis;Animal Model;Cell Culture Techniques;Cell model;Cell Nucleus;Cell Physiology;Clinical;cohort;Cultured Cells;Cytoplasm;design;Disease;Disease Progression;disease-causing mutation;Etiology;experimental study;frontal lobe;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;fused in sarcoma;Future;Genetic;Impairment;In Vitro;in vivo;innovation;insight;interdisciplinary approach;Label;Laboratory Finding;Light;Liquid substance;Lobe;Measures;Mediating;Membrane;Messenger RNA;Methods;Molecular;mouse model;mRNA Decay;mRNA Surveillance;Mus;mutant;Mutation;Names;Nerve Degeneration;neuron loss;Neuronal Dysfunction;Neurons;neurotoxicity;nonalzheimer dementia;Nonsense-Mediated Decay;novel;optogenetics;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Patients;Phase;Play;Polyribosomes;polysome profiling;Post-Translational Protein Processing;Process;Prosencephalon;protein aggregation;Proteins;Proteomics;Protocols documentation;Publishing;Puromycin;Research;Ribonucleoproteins;RNA;RNA Binding;Role;spatiotemporal;System;Temporal Lobe;Testing;therapeutic development;Tissues;Toxic effect;transcriptome sequencing;Transgenic Mice;Translating;translational impact;Translations;Work

PROJECT_TITLE: RNA Surveillance and Protein Translation in FTD

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Nutrition;Obesity

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The brain consumes a disproportionate amount of energy, and it is not known how the brain balances its energetic needs with those of the rest of the body. Proposed studies investigate a mechanism by which a protein that evolved from a virus directly transmits needs from the brain to fat storage cells. The goal is to transform our understanding of how energy imbalance, such as in obesity, perturbs neurodevelopment and cognitive functions.

PI_NAMEs: REIS, TANIA  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Address;Adipose tissue;Association Learning;Back;Behavioral;Body part;Brain;Calories;Capsid;Capsid Proteins;Cells;Chronic;Circulation;cognitive function;Communication;Consumption;Coupled;Custom;Cytoskeleton;design;Diet;dietary excess;Disparate;energy balance;Energy Supply;experimental study;Fatty acid glycerol esters;Goals;Impaired cognition;Learning;Mediating;Memory;Messenger RNA;Metabolic Control;Metabolic syndrome;Metabolism;Modeling;Modification;Molecular;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Disorder;Neurons;Obesity;Organ;Pathway interactions;Play;Process;Property;protein expression;protein oligomer;Proteins;Research;Rest;Retroviridae;Role;Signal Transduction;Synapses;System;Testing;Tissues;transmission process;Travel;Virus;Virus-like particle

PROJECT_TITLE: Food for thought: a virus-like signal for the energetic demands of higher cognitive functions


ORG_CITY: RAPID CITY

ORG_NAME: BLACK HILLS CTR/AMERICAN INDIAN HEALTH

ORG_STATE: SD

PHR: This Lakota Center for Health Research NARCH program project renewal application will: 1) Continue the productive partnership with 3 Lakota Sioux Tribes in western South Dakota; 2) Focus research on a culturally- relevant, trauma-informed mindfulness-based smoking cessation for Northern Plains Tribal women who have experienced intimate partner violence; 3) Implement a community wastewater treatment testing process, including SARS-CoV-2, on the Cheyenne River Sioux Tribe Reservation; and 4) Build further capacity within our Tribal partners for the support and conduct of future health disparities-related research.

PI_NAMEs: HENDERSON, JEFFREY A (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: 2019-nCoV;Arizona;biobank;Cheyenne;Cities;Communities;Coupled;design;Environment;Evaluation;experience;Funding;Future;Health;Health Disparities Research;health inequalities;Human;improved;Indian reservation;Inequity;Infrastructure;innovation;Intervention Trial;intimate partner violence;medical schools;member;mindfulness;Native American Research Center for Health;Northern Plains Tribe;Persons;phrases;pilot test;Planet Earth;Process;process improvement;Productivity;Program Research Project Grants;programs;Research;Research Personnel;Research Project Grants;RNA;Running;Sioux Indians;smoking cessation;South Dakota;Testing;Teton Sioux Indian;Thinking;Translating;Trauma;Tribal group;Tribes;Universities;Woman

PROJECT_TITLE: Lakota Center for Health Research


PI_NAMEs: HOLSTEIN, SARAH A (contact)

PROJECT_TERMS: Acute leukemia;Adult;Antineoplastic Agents;Award;Basic Science;bench to bedside;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer imaging;cancer therapy;Chemicals;Childhood;Clinic;clinical translation;Clinical Trials;Collaborations;commercialization;computational chemistry;Computer Analysis;copolymer;delivery vehicle;Detection;Development;Direct Costs;Docking;drug development;Evaluation;Faculty;Foundations;Funding;Future;Gene Expression;Genetic;Goals;Hematologist;Hyaluronic Acid;in silico;Intellectual Property;inter-institutional;interest;Investigation;Investments;Journals;Lymphoma;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Medulloblastoma;member;Methods;Mission;Molecular;Molecular Target;Multiple Myeloma;Nanodelivery;nanomaterials;NCI Center for Cancer Research;Nebraska;neoplastic cell;new technology;next generation;novel;novel strategies;Oncogenes;Oncologist;Oncology;Pediatric Hematologist;Pediatric Oncologist;Peer Review;Pharmaceutical Chemistry;Pharmacology;Physicians;Population;preclinical study;programs;prospective;Protac;Publications;Radiation Oncologist;Radiosurgery;Regulation;Reporting;Research;Research Personnel;Resource Sharing;Resources;RNA Interference;Scientist;Signal Transduction;small molecule;Structure;Surgical Oncologist;Synthesis Chemistry;Technology;Technology Transfer;Testing;Therapeutic;tool;Training and Education;Translational Research;translational research program;translational study;Translations;tumor;Validation

PROJECT_TITLE: Targets, Modulators and Delivery Program


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative We propose to create systemic and sustainable culture change to support inclusive excellence in research by recruiting clusters of faculty focused on health disparities, specifically in the areas of cancer, obesity and diabetes, cardiovascular disease, and neuroscience. We will recruit and select 12 junior faculty who are committed to diversity, and provide supportive institutional environments to facilitate their development of successful independent research programs. Support will include individual career development, infrastructure and assistance, opportunities for networking and collaboration, and changes to policy and environment to reduce isolation, build community, and increase retention.

PI_NAMEs: DURANT, RAEGAN WINSTON;FOUAD, MONA N. (contact);TURNER, TIMOTHY

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Acceleration;Address;Advocate;Affect;Alabama;Area;Cardiovascular Diseases;career;career development;cohort;Collaborations;collaboratory;Communities;community building;Development;Development Plans;Diabetes Mellitus;diversity and equity;diversity and inclusion;early-career faculty;Ensure;Environment;equity, diversity, and inclusion;Evaluation;experience;Faculty;Fostering;Foundations;Goals;Grant;health disparity;Health Status;improved;Individual;Infrastructure;Institution;Institutional Policy;interest;Location;Logistics;Malignant Neoplasms;Mentors;model design;Modeling;Neurosciences;Obesity;Outcome;peer networks;peer support;Policies;Positioning Attribute;programs;recruit;Research;Research Personnel;Research Support;Research Training;Resources;Rural;Scientist;Series;social;success;Surgeon;Testing;United States National Institutes of Health;Universities;Washington;Work

PROJECT_TITLE: UAB/Tuskegee Faculty Institutional Recruitment for Sustainable Transformation (UAB/TU FIRST) Partnership (NIH U54)