NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Project Narrative Craving is one of the most clinically-important symptoms experienced by individuals in treatment, including those with opioid use disorders for whom several evidence-based treatments exist. Unfortunately, these treatments do not adequately address craving and reuse and relapse are the modal outcomes. If successful, this study will have uncovered a previously unknown biological indicator of how craving works to bias decisions toward drug use in addicted individuals. Studies can then use this indicator as a target of treatment, perhaps ultimately culminating in the implementation of interventions to reverse the specific decision biases induced by craving and thus improve patient outcomes.

PI_NAMEs: KONOVA, ANNA BORISOVA (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: addiction;Address;Algorithms;Amygdaloid structure;Architecture;Area;Behavior;behavior change;Behavioral;behavioral study;Biological;Biometry;Brain;Clinical;cognitive control;Corpus striatum structure;craving;Crossover Design;Cues;Decision Making;design;Dorsal;drug craving;Drug Regulations;Drug usage;Economics;Emotions;Evidence based treatment;experience;Food;food craving;Functional Magnetic Resonance Imaging;Health;Human;human imaging;Image;imaging study;implementation intervention;improved;improved outcome;indexing;Individual;Insula of Reil;Knowledge;Link;Mathematics;Measures;Mental disorders;Methods;Modality;Modeling;neural;neural circuit;neural correlate;Neurobiology;neuroeconomics;neurofeedback;Neurosciences;non-drug;novel;Opioid;opioid epidemic;opioid use disorder;Outcome;Participant;Patient-Focused Outcomes;Patients;Pattern;personalized intervention;Persons;Pharmaceutical Preparations;pre-clinical;Precipitating Factors;Prefrontal Cortex;prevent;Procedures;Process;Psychology;Public Health;Qualifying;Relapse;Research;Rewards;Role;societal costs;standard care;Symptoms;Testing;Time;Work

PROJECT_TITLE: Decision Neuroscience of Craving

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: NARRATIVE Alzheimer's disease is a devastating and incurable neurodegenerative disorder projected to affect 13 million individuals in the US by 2050. Integrating results from human genetic studies with innovative model organism investigations, we will discover the mechanisms responsible for risk of Alzheimer's disease and related dementias. Improved functional understanding of Alzheimer's disease susceptibility, including disease amplifying and protective factors, holds enormous potential for therapeutic breakthroughs.

PI_NAMEs: BELLEN, HUGO J;BOTAS, JUAN ;MILOSAVLJEVIC, ALEKSANDAR ;SHULMAN, JOSHUA M (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Acceleration;Adult;Affect;age related neurodegeneration;Aging;Alleles;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;Architecture;Atlases;Behavior;Bioinformatics;Biological Assay;Biological Models;Brain;Brain imaging;Candidate Disease Gene;cell type;Clinical;Code;Cognition;Collaborations;Communities;Complex;Data;Disease;Disease susceptibility;disorder risk;Dissection;Drosophila genus;Drosophila melanogaster;Encyclopedia of DNA Elements;Endocytosis;endophenotype;Enhancers;epigenome;epigenomics;experience;falls;fly;follow-up;functional genomics;gene conservation;gene interaction;Genes;genetic analysis;Genetic study;genetic technology;genetic variant;genome resource;genome wide association study;genomic data;Genomics;Heterogeneity;high throughput screening;Histology;Homologous Gene;Human;human data;Human Genetics;improved;in vivo;Individual;Infrastructure;innovation;instrumentation;Investigation;knockout gene;loss of function;Maps;Mediating;Medicine;model organism;Modeling;Molecular;motor impairment;Natural Immunity;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;Neuroglia;Neuronal Dysfunction;Neurons;neurophysiology;Neurosciences;Pathologic;Pathology;Pathway interactions;Persons;Phenotype;Pre-Clinical Model;Predisposition;progressive neurodegeneration;protective allele;protective factors;protein TDP-43;Proteome;proteostasis;Publishing;rare variant;Research;Resolution;Resources;risk variant;Robotics;screening;Source;Structure;Synapses;System;tau Proteins;Tauopathies;Technology;Testing;Therapeutic;tool;Transcend;transcriptome;translation to humans;translational barrier;Transmission Electron Microscopy;United States National Institutes of Health;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: Functional Genomic Dissection of Alzheimer's Disease in Humans and Drosophila Models


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Cost Effectiveness Research;Digestive Diseases;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Racial and Ethnic Minority Health Research;Urologic Diseases;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Pelvic floor disorders are common, costly, and their prevalence is increasing in the United States. The impact of pelvic floor disorders is particularly high on underserved minority women. Investigators at the University of Pennsylvania are committed to developing and testing innovative new treatments for urinary and fecal incontinence and pelvic organ prolapse through high quality clinical trials that include large proportions of underserved minorities.

PI_NAMEs: HARVIE, HEIDI S (contact)

PROGRAM_OFFICER_NAME: TEPEDE, ABISOLA KAFAYAT

PROJECT_TERMS: African American;Area;Behavior Therapy;Behavioral;Black race;Botulinum Toxin Type A;Budgets;Clinical;Clinical and Translational Science Awards;clinical infrastructure;Clinical Investigator;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Design;Collaborations;Colorectal Surgery;Communication;Consultations;cost;cost effective;Cost Effectiveness Analysis;Dedications;Delaware;design;Development;Electronics;Enrollment;Environment;ethnic diversity;experience;Fecal Incontinence;fecal transplantation;Feces;Fellowship;Funding;Genetic;Genomics;Geographic Locations;gut microbiome;Health;Healthcare;Hospitals;Human Resources;Imaging Techniques;Infrastructure;innovation;Inpatients;Institution;Intervention;Leadership;Location;member;metabolome;metabolomics;microbiome;minority subjects;Minority Women;Modeling;Modernization;Multicenter Trials;multidisciplinary;New Jersey;Nurse Practitioners;Nursing Research;Operative Surgical Procedures;Outpatients;patient oriented;patient population;Patients;Pelvic Floor Disorders;Pelvic floor structure;pelvic organ prolapse;Pennsylvania;Pharmacogenetics;Population;Prevalence;Productivity;programs;Proteomics;protocol development;Protocols documentation;Publications;Randomized;randomized trial;randomized, clinical trials;Records;recruit;Recurrence;Reporting;Research;Research Design;Research Infrastructure;Research Personnel;retention rate;Scientific Advances and Accomplishments;Site;Specialist;Specific qualifier value;study population;Techniques;Technology;Testing;Text Messaging;Training;translational medicine;Translational Research;translational study;translational therapeutics;underserved minority;United States;Universities;University resources;Urinary Incontinence;Urologist;Urology;Woman;Women's Health;Work

PROJECT_TITLE: Pelvic Floor Disorders Network


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: CORVALLIS

ORG_DEPT: BIOLOGY

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: This proposal addresses the PGNB Nutrition Research program’s call for research on “the role of nutrition in infant development” and “the contributions of human milk and its components to optimal infant nutrition” in that it examines how different milk processing methods affect preservation of bioactive protein structure and function, which could lead to major impacts in preterm infant health outcomes.

PI_NAMEs: DALLAS, DAVID CHARLES (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Address;Adhesives;Affect;Aftercare;Anti-Bacterial Agents;bile salts;Biological;Biological Assay;donor milk;Ensure;Enzyme-Linked Immunosorbent Assay;feeding;Goals;Growth;Health;Human Milk;Immune system;Immunoglobulins;immunoregulation;improved;In Vitro;Infant;Infant Development;Infant Health;infant nutrition;Infection;irradiation;Lactoferrin;Lipase;Methods;microbiome;Milk;Milk Banks;Milk Proteins;Mothers;Muramidase;nutrient absorption;nutrition;Nutritional;Nutritional Study;Outcome;pasteurization;pathogen;Peptide Hydrolases;Predisposition;Premature Infant;preservation;pressure;Process;programs;protein function;protein structure;Proteins;Proteomics;Research;Risk;Role;Safety;Shapes;Source;Techniques;ultraviolet;unpasteurized;Viral;Work

PROJECT_TITLE: Can high pressure processing (HPP) and ultraviolet-C irradiation (UV-C) treatment preserve donor milk bioactive protein structure and function better than holder pasteurization?

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE This project is focused on the fundamental molecular mechanisms underlying leukemia. Highly relevant to the mission of the NIH, the data obtained will provide new insights into how modifications to RNA by oncogenes can lead to cancer. The highly innovative  studies will reveal novel targets that can be applied to the development of improved  therapeutic approaches for other cancer types as well.

PI_NAMEs: HALENE, STEPHANIE ;KRAUSE, DIANE S (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: acute megakaryoblastic leukemia cell;Acute Megakaryocytic Leukemias;Affect;Animal Model;Binding;Biological;Biological Assay;cancer type;Cell Line;Cells;Cessation of life;Chimeric Proteins;Chromatin;clinically relevant;cofactor;Complex;Coupled;crosslink;Data;Data Set;Dependence;Development;Disease;DNA;Dominant-Negative Mutation;Doxycycline;epitranscriptome;Event;Exons;Fetal Liver;Fusion Protein Expression;Gene Expression;Genes;Genetic Engineering;Genetic Transcription;Genome;genome-wide analysis;Genomic approach;Growth;Hematopoietic;Human;Immunoprecipitation;improved;Individual;inducible gene expression;innovation;insight;Knock-in Mouse;leukemia;leukemogenesis;Light;Link;Malignant Neoplasms;Maps;Mediating;Megakaryocytes;Messenger RNA;Methylation;Methyltransferase;Mission;Modeling;Modification;Molecular;Mus;Mutation;novel;Oncogenes;Oncogenic;overexpression;Pathway interactions;Patients;Play;posttranscriptional;prevent;programs;promoter;Publishing;recruit;Recurrence;Regulation;response;RNA;RNA analysis;RNA metabolism;RNA methylation;RNA Stability;Role;Sampling;Serum Response Factor;Site;Testing;Therapeutic;Transcript;transcription factor;transcriptome sequencing;Translations;translatome;treatment optimization;tRNA Methyltransferases;tumorigenesis;United States National Institutes of Health;Xenograft procedure

PROJECT_TITLE: Mechanisms of Leukemogenesis in AMKL

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE: Acute systemic inflammation, such as that seen after severe infections, leads to endothelial-mediated vascular dysfunction that is a costly burden to modern healthcare systems with a high morbidity and mortality. This research program aims to apply a multi-modal approach to elucidate the vascular mechanisms resulting from acute, systemic inflammation using integrated and complimentary themes involving animal studies, human populations and biochemical and molecular techniques. The overall goal is to better understand the effect of acute vasculopathy on critically ill patients and discover better ways to diagnose and treat them.

PI_NAMEs: STARK, RYAN J (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acute;Affect;Animal Model;Animal Testing;Animals;Biochemical;Biological Assay;Blood Vessels;Cells;Chronic;Clinical;Coagulation Process;cost;Coupled;Critical Illness;cytokine;Data;Diagnosis;drug discovery;effective therapy;endothelial dysfunction;Endothelium;Failure;Functional disorder;Genetic;genomic signature;Goals;Healthcare Systems;Homeostasis;Human;Immune response;improved;Infection;Inflammation;Inflammatory;interest;Lasers;Lead;Left;Leukocyte Trafficking;Ligation;Liquid substance;Mediating;Metabolic Pathway;Microfluidic Microchips;mitochondrial dysfunction;Modeling;Modernization;Modification;Molecular;Monitor;Morbidity - disease rate;mortality;multimodality;Nitric Oxide;novel;Outcome;Oxidative Stress;pathogen;Pathway interactions;patient population;Patients;Pattern;Penetration;Peptides;Perfusion;Population;Procedures;programs;protein aminoacid sequence;protein protein interaction;Proteins;proteomic signature;Reactive Oxygen Species;Research;Signal Transduction;spatiotemporal;Supportive care;System;systemic inflammatory response;Systemic Inflammatory Response Syndrome;Techniques;Testing;Therapeutic;Tissues;Vascular Diseases;Vasodilator Agents

PROJECT_TITLE: Mechanisms of vascular dysfunction in acute systemic inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative Reflection of the past brings awareness and comprehension to why inequities in oral health exist and continue to pose major public health threats, how public oral health policies have developed and been implemented, where innovations in oral health have occurred, what oral health care means to overall health, and who has been and can be responsible for shaping the trajectory of the dental profession. By translating these larger humanities-based themes into interactive, age-appropriate, and NGSS oriented lessons, P-12 learners will gain an understanding of how oral health care has progressed and impacted the world around them, as well as how they too can fit into the continuing story of dentistry and oral health. To accomplish this goal, the project will create accessible, freely available educational modules that combine the health sciences, humanities, and STEM to increase oral health literacy and awareness of pathways to the dental and dental research professions.

PI_NAMEs: CUTTER, PATRICK  (contact);MANSKI, RICHARD J

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Age;Ally;Awareness;career;case history;Case Study;Collection;Communities;Comprehension;craniofacial;Dental;Dental General Practice;Dental Research;Dental Technology;Dentistry;Development;Discipline;Discrimination;Disparity;disparity reduction;diversity and equity;Economics;Education;education planning;education research;education resources;Educational Curriculum;Ensure;Equity;Evaluation;evidence base;experience;Fostering;Foundations;Future;Goals;Health;Health education;health literacy;Health Occupations;Health Personnel;Health Policy;Health Sciences;Health Services Accessibility;Healthcare;Healthcare Systems;History of Dentistry;Humanities;improved;Individual;Inequality;Inequity;innovation;interest;Knowledge;Lead;Learning;Learning Module;learning strategy;life span;marginalized population;Medical;Modeling;Morals;Museums;novel strategies;Oral;Oral health;Participant;Pathway interactions;Patients;Persons;Procedures;programs;Public Health;Quality of life;Recording of previous events;recruit;Research;Research Personnel;Science;Shapes;social;Standardization;Techniques;tool;Translating;Underrepresented Populations;Underserved Population;United States

PROJECT_TITLE: A Mouthful of History

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE We aim to train the next generation of scientists to understand, treat and prevent movement disorders, and to become rigorous and creative investigators. We will provide predoctoral trainees with both specialized research training in their chosen discipline and give them an appreciation for the broader issues related to motor control and movement disorder-related research, from molecular, systems, behavioral to computational. We have an experienced and dedicated team of researchers in a rich and collaborative academic environment.

PI_NAMEs: HALE, MELINA E;HATSOPOULOS, NICHOLAS G (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: motor control;neural;Neuromechanics

PROJECT_TITLE: Neural, Computational, and Neuromechanical Approaches to Motor Control


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: NOTRE DAME

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE: The delivery of drugs to sites of need, while sparing healthy tissue from often toxic side-effects, remains a challenge in drug delivery. Targeted carriers have been explored, often leveraging biological affinity, yet these localize only a small percent of an administered drug. We are developing a molecular-scale synthetic approach to target drugs to desired sites in the body through rapid formation of long-lived non-covalent affinity interactions.

PI_NAMEs: WEBBER, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Affinity;Antibodies;Attenuated;Binding;Biological;Cells;Chemistry;design;Devices;Disease;Dose;Drug Delivery Systems;Drug Kinetics;Drug or chemical Tissue Distribution;Drug Targeting;Drug usage;Ensure;Future;Home;Homing;implantable device;In Situ;In Vitro;interest;Kinetics;Ligation;metabolic engineering;Methodology;molecular recognition;molecular scale;Pharmaceutical Preparations;Physiological;Prodrugs;programs;Property;Proteins;remote intervention;Research;Route;side effect;Site;small molecule therapeutics;systemic toxicity;Technology;Therapeutic;Therapeutic Agents;Time;Tissues;Toxicant exposure;Variant

PROJECT_TITLE: Non-Covalent Molecular Recognition for Drug Targeting in the Body

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


NIH_SPENDING_CATS: Cerebrovascular;Neurosciences

ORG_CITY: CINCINNATI

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: The overall goal of our T32 training program is to train and mentor clinician scientists from the disciplines of neurology and emergency medicine who will become collaborative leaders and clinical trial investigators in the investigation of the causes and treatment of stroke, cerebrovascular disease, and neurocritical care.

PI_NAMEs: BRODERICK, JOSEPH PAUL (contact);DEMEL, STACIE

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TITLE: Cerebrovascular Fellowship Training Program


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Emerging Infectious Diseases;Immunization;Infectious Diseases;Neurodegenerative;Neurosciences;Orphan Drug;Prevention;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE);Vaccine Related

ORG_CITY: FORT COLLINS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE No prophylactic or therapeutic regimen is known for any prion disease. We have developed novel vaccine strategies 6-8,16, a carefully-graded chronic wasting disease (CWD) challenge 9,10 and longitudinal monitoring system using ultrasensitive CWD detection methods in white-tailed deer 9,10,12,13, to permit vaccine assessment in the native host. In summary, we will determine the efficacy, safety and ability of prototype vaccines, alone or additive in combination to protect against prion infection.

PI_NAMEs: MATHIASON, CANDACE K. (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Adjuvant;American;Animal Model;Animals;anti-PrP antibodies;Antigens;Asia;Biological Assay;Blood;Bodily secretions;Brain;Cattle;Cellular Immunity;cervid;Chronic Wasting Disease;cohort;Combined Vaccines;comparative;conformer;Consumption;cytokine;Data;Deer;detection method;Development;Disease;Disease Outbreaks;Dose;Economics;efficacy evaluation;Environment;Environmental Pollution;Enzyme-Linked Immunosorbent Assay;Europe;Euthanasia;Excretory function;Feces;Flow Cytometry;Health;Human;Humoral Immunities;Immune response;Immunize;Immunoglobulin A;Immunoglobulin G;Immunohistochemistry;Industry;Infection;Inflammation;innovation;Macaca;Modeling;Molecular Conformation;Monitor;Neurodegenerative Disorders;nonhuman primate;North America;novel;novel vaccines;Oral;Outcome;overexpression;Pathologic;Peripheral Blood Mononuclear Cell;Personal Satisfaction;Population;Practice Management;Prion Diseases;Prions;Productivity;prophylactic;Protein Isoforms;prototype;PrP;PrPSc Proteins;Public Health;rational design;Regimen;Reindeer;Research;Risk;risk mitigation;RNA;Safety;Saliva;side effect;Stains;System;Tail;Testing;Therapeutic;Time;Tissues;tool;Transgenic Mice;translational impact;transmission process;Urine;Vaccinated;Vaccination;vaccination strategy;vaccine candidate;Vaccine Design;vaccine strategy;Vaccines;Zoonoses

PROJECT_TITLE: Chronic Wasting Disease Vaccines

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Aging;Osteoporosis

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative The proposed studies will elucidate the molecular and cellular mechanisms by which continuous PTH administration has catabolic effects in bone. Our long-term goal is to establish as strong scientific basis to target these mechanisms enabling the design of cost-effective bone anabolic agents with less toxicity, and convenient use for the treatment of osteoporosis.

PI_NAMEs: WANG, BIN  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Adverse effects;Anabolic Agents;Anabolism;Arginine;arm;beta catenin;bone;Bone Formation Stimulation;bone loss;Bone Marrow Cells;bone marrow mesenchymal stem cell;bone metabolism;Bone remodeling;Bone Resorption;Calcium;Calvaria;Catabolism;Cells;Coculture Techniques;cost effective;CRISPR/Cas technology;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;desensitization;design;Dissociation;Down-Regulation;efficacy evaluation;Exposure to;extracellular;Felis catus;Goals;Grant;GTP-Binding Protein alpha Subunits, Gs;Histologic;Homeostasis;Implant;improved;In Vitro;in vivo;Infusion procedures;Injections;Knock-out;Left;Ligands;Lysine;Mediating;Metabolic Bone Diseases;microCT;mineralization;Modeling;Molecular;mouse model;multicatalytic endopeptidase complex;Mus;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Nuclear;old mice;Oral;osteoblast differentiation;Osteoblasts;Osteoclasts;Osteogenesis;Osteoporosis;Parathyroid Hormone Receptor;Pathogenicity;Pathway interactions;Phospholipase C;Play;pre-clinical;prevent;Production;Proteasome Inhibitor;PTH gene;Publishing;Receptor Activation;Receptor Down-Regulation;receptor downregulation;receptor expression;Receptor Signaling;Regulation;Research;response;Role;Safety;side effect;Signal Pathway;Signal Transduction;Techniques;Testing;Therapeutic;TNFSF11 gene;Toxic effect;Treatment Efficacy;Ubiquitin;Ubiquitination;X-Ray Computed Tomography

PROJECT_TITLE: Targeting the ubiquitin-proteasome pathway to reverse catabolic action of PTH in bone

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: BLACKSBURG

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Veterinarians are uniquely qualified to conduct biomedical research using animal models, but relatively few go into this field of work due to a lack of research training opportunities. This proposal aims to rectify this situation by enrolling veterinarians in a Ph.D. program that equips them with the fundamentals of conducting hypothesis- driven, cutting-edge biomedical research using state-of-the-art technologies and encourages their pursuit of careers in research in academia, industry and /or government.

PI_NAMEs: MENG, XIANG-JIN  (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Animal Model;Research;Veterinarians

PROJECT_TITLE: Animal Model Research for Veterinarians (AMRV)


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative “Training for Transformative Discovery in Psychiatry” is an institutional training grant designed to educate physicians and Ph.D. scientists in conducting research which utilizes the recent advances in our understanding of brain development and function to lead to discoveries of novel treatments for mental illness.

PI_NAMEs: SWEET, ROBERT A (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Psychiatry;Training


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative  The “Scientific Communication Advances Research Excellence 2.0” program (SCOARE 2.0) is relevant to public health because it will contribute to building and sustaining a diverse and highly skilled biomedical and behavioral research workforce. The program will continue to provide innovative, evidence- based mentor training in the principles and practices of scientific communication (SciComm) skill development and broaden its impact through the addition of novel content and translation to a hybrid asynchronous delivery format. The SCOARE 2.0 program is relevant to the NIH goal of supporting educational activities that complement and/or enhance the training of a research workforce meeting the nation’s biomedical, behavioral and clinical research needs.

PI_NAMEs: CAMERON, CARRIE A. (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Address;Administrator;Affective;Applied Skills;Awareness;Behavioral Research;biobehavior;Biomedical Research;career;Clinical Research;Cognitive;Collaborations;Communication;Complement;design;Development;Educational Activities;Educational Curriculum;Educational process of instructing;Educational workshop;Effectiveness;Ensure;Evaluation;evidence base;expectation;experience;Faculty;faculty mentor;Feedback;Future Teacher;Goals;Hybrids;improved;innovation;Instruction;Intention;Investments;Knowledge;Language;Learning;Linguistics;Link;Measurable;meetings;Mentors;Motivation;National Institute of General Medical Sciences;non-Native;novel;Oral;Outcome;Participant;participant retention;pedagogy;Play;Positioning Attribute;Program Sustainability;programs;Public Health;Research;Research Personnel;Resources;Role;Scientist;Self Efficacy;skill acquisition;skills;social;Social Identification;Teacher Professional Development;Time;Training;Translating;Translations;Uncertainty;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: Scientific Communication Advances Research Excellence (SCOARE) 2.0


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE / RELEVANCE  This project seeks to investigate the molecular function and evolution of long noncoding RNAs (lncRNAs) in mammalian gene regulation, in particular, X chromosome dosage compensation. Abnormalities in dosage compensation and dysregulation of lncRNAs have been linked to many human developmental disorders and diseases including cancer. Research findings from this proposal will provide essential knowledge for applying lncRNAs in health diagnostics and will contribute to new methods for targeted disease therapies and prevention.

PI_NAMEs: SUN, SHA  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Affect;Animals;autosome;Binding;Cells;Chromosomes;Code;Conserved Sequence;CRISPR/Cas technology;Data;Deer Mouse;Defect;Development;developmental disease;Diagnostic;Disease;Distant;Dosage Compensation (Genetics);Dose;Elements;embryo cell;Embryo Deaths;embryonic stem cell;Engineering;epigenetic regulation;Evolution;Experimental Models;Failure;Female;fly;Gene Cluster;Gene Expression;Gene Expression Regulation;gene product;Gene Silencing;Genes;genetic evolution;genetic sex determination;Genetic Transcription;Genetic Variation;Health;Homologous Gene;Human;human disease;Hybrids;In Vitro;in vivo;insight;Knock-in;Knowledge;Length;Link;male;Malignant Neoplasms;Mammals;Maps;Marsupialia;Measures;Mediating;Methods;Modeling;Molecular;mouse genome;Mus;Nucleotides;Pattern;Peromyscus;Phylogenetic Analysis;Plants;Prevention;Primates;Property;Proteins;Reporting;Research;RNA;Rodent;Role;Sequence Alignment;sex;Sex Chromosomes;Site;Site-Directed Mutagenesis;stem;Structure;System;Transcript;Transgenes;Transgenic Mice;Transgenic Organisms;Untranslated RNA;Variant;Visualization;X Chromosome;X Inactivation;Y Chromosome

PROJECT_TITLE: Elucidating the molecular basis of lncRNA evolution for mammalian dosage compensation

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Spore-forming bacteria cause over a million infections each year, and spores are central to the infectious cycle of these pathogens and can resist antibiotics and sterilization. In this proposal we will determine the molecular mechanisms underlying spore germination. Our work will enable the development of treatments that either inappropriately induce germination, leaving cells vulnerable to standard antibacterial therapies, or block it, directly preventing disease.

PI_NAMEs: KRUSE, ANDREW ;RUDNER, DAVID Z (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Address;Alanine;Amino Acid Substitution;Amino Acids;Anti-Bacterial Agents;Antibiotics;Bacillus megaterium;Bacillus subtilis;Bacteria;Behavior;Binding;Biochemical;Cations;Cell Wall;Cells;Chemicals;Clostridium difficile;Complex;crosslink;Cytology;Data;Detection;detection of nutrient;dipicolinic acid;Disease;Exposure to;Family;Food;Food Industry;foodborne illness;Genetic;Germination;Glucose;Growth;Hydration status;Hydrolase;in vivo;Infection;insight;Ion Channel;Ion Channel Gating;Ions;Leucine;Life;Ligand Binding;Ligands;Lipid Bilayers;Mediating;Membrane;Metabolic;Methods;Modeling;Molecular;Monovalent Cations;Mutagenesis;Nucleosides;Nutrient;Nutritional Requirements;Operon;pathogen;Pathway interactions;Peptidoglycan;prevent;programs;Proline;protein complex;Proteins;receptor;Reproduction spores;Resolution;response;Series;Signal Transduction;Signal Transduction Pathway;small molecule;Specificity;Sterilization;Structural Models;Structure;sugar;Testing;therapy development;Variant;Work

PROJECT_TITLE: Molecular basis of spore germination

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Infectious Diseases;Orphan Drug;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative: Functional Analysis of the Clp Protease Systems in Chlamydial Growth and Differentiation Chlamydiae are important pathogens of humans and significant causes of morbidity, causing a range of illnesses including sexually transmitted diseases, trachoma, pneumonia, and other respiratory tract infections. The burden of these infections stems from their lack of symptoms, which can lead to chronic conditions such as infertility, adult-onset asthma, and, in some cases, possibly exacerbating heart disease. The work proposed here is to define the role of conserved and novel elements associated with protein degradation in chlamydiae, which in turn may lead to the design of novel therapeutics that would eliminate the broad effects of standard antimicrobial therapy on normal flora.

PI_NAMEs: FISHER, DEREK JAMES;OUELLETTE, SCOT P (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Adult;antimicrobial;Arginine;Asthma;ATP phosphohydrolase;Bacillus subtilis;Bacteria;Binding Sites;Biochemical;biological adaptation to stress;Biological Assay;Biology;Blindness;Cell Cycle;Cell Physiology;Cells;Centers for Disease Control and Prevention (U.S.);Chlamydia;Chlamydia Infections;Chlamydia trachomatis;Chronic;ClpX protein;Complex;Cytoplasm;Data;Dependence;design;Developed Countries;Developing Countries;Development;Differentiation and Growth;Disease;Drug Targeting;Elements;Ensure;Essential Amino Acids;Genes;Genetic;Genetic Techniques;Genetic Transcription;Genome;Goals;Growth;Growth and Development function;Healthcare Systems;Heart Diseases;Homeostasis;Human;human pathogen;Immunologics;In Vitro;in vivo;Incidence;infection burden;Infertility;interest;Interferon Type II;Maps;Mediating;Metabolic;Molecular Chaperones;Morbidity - disease rate;Morphology;mutant;normal microbiota;novel;novel therapeutics;Operon;Organism;Orthologous Gene;overexpression;Oxidation-Reduction;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Patients;Pelvic Inflammatory Disease;Peptide Hydrolases;Peptides;phospho-L-arginine;Phosphotransferases;Pneumonia;Process;protein degradation;Protein Isoforms;Proteins;Proteome;Proteomics;proteostasis;Regulation;Reiter Disease;Reporting;Respiratory Tract Infections;Role;Sexually Transmitted Diseases;Signal Pathway;Signal Transduction;stem;Stress;Symptoms;System;Therapeutic;Therapeutic Agents;therapeutic target;tmRNA;tool;Trachoma;Translating;Translations;Tryptophan;tubal infertility;Work

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Batten Disease;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE The Neuronal Ceroid Lipofuscinoses comprise a group of inherited and fatal pediatric neurodegenerative disorders affecting approximately 6-8 infants per 100,000 live births, the CLN3 subtype is the most common. This application aims to continue hit-to-lead development of a library of multifunctional compounds that act to enhance the expression of the anti-apoptotic protein Bcl-2, reduce ceramide synthesis and activate autophagy, resulting in ability to rescue the pro-apoptotic and defective autophagy phenotypes of CLN3 patient induced pluripotent stem cell-derived neurons and rescue neurobehavioral deficits in a CLN3 mouse model.

PI_NAMEs: TRIPPIER, PAUL  (contact)

PROGRAM_OFFICER_NAME: PAWLYK, AARON C

PROJECT_TERMS: Acceleration;Affect;Apoptosis;Apoptotic;Autophagocytosis;BCL2 gene;Behavior;behavioral phenotyping;Blindness;cancer therapy;Cells;Ceramides;Cessation of life;Chemicals;cheminformatics;Child;Childhood;Cognitive;cognitive function;common symptom;Credentialing;Data;Death Rate;Dementia;design;Deterioration;Development;Disease;disease model;disease phenotype;disorder subtype;drug discovery;Drug Kinetics;drug metabolism;effective therapy;experience;Family;Functional disorder;Generations;Genes;Goals;Homeostasis;Impaired cognition;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Induction of Apoptosis;Infant;Inherited;innovation;Knock-in Mouse;Lead;lead optimization;Libraries;Link;Live Birth;Medical;Memory;Mitochondria;mitochondrial dysfunction;Modeling;Modification;Motor;mouse model;Mus;Mutation;Nature;nerve stem cell;neurobehavioral;Neurodegenerative Disorders;neuron loss;Neuronal Ceroid-Lipofuscinosis;Neurons;neuroprotection;patient derived induced pluripotent stem cells;Patients;PC12 Cells;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;pharmacophore;Phenotype;Physiological Processes;premature;Process;Production;Property;protective effect;Proteins;Reporting;scaffold;screening;Seizures;Severities;small molecule;Spielmeyer-Vogt Disease;stem cell model;Structure;synergism;Therapeutic;Therapeutic Agents;therapeutic development;therapeutic target;therapeutically effective;Tissues;Toxic effect;Transgenic Mice;Transgenic Organisms;Visual impairment

PROJECT_TITLE: Small Molecule Drug Discovery for CLN3 and CLN6 Disease


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Kidney Disease

ORG_DEPT: PEDIATRICS

PHR: Together, these studies seek to define how the miR-17~92 cluster in renal epithelia functions to regulate the expression of pro-fibrotic factors as part of tubulointerstitial crosstalk during the progression to chronic kidney disease. This work has translational relevance, as it establishes the basis for a novel therapeutic approach using members of the miR-17~92 family (and/or key mRNA targets) to ameliorate the progression of renal fibrosis.

PI_NAMEs: HO, JACQUELINE  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Adult;Aging;autosome;Cells;Chronic Kidney Failure;Collagen;Data;Diabetes Mellitus;Disease;Effectiveness;Etiology;Extracellular Matrix Proteins;Family;Fibrosis;gain of function;Genes;Hypertension;In Vitro;Individual;inducible gene expression;Infusion procedures;Injury to Kidney;innovation;Intervention;Kidney;Kidney Diseases;Kidney Failure;kidney fibrosis;Kidney Transplantation;Laboratories;Mediating;member;Messenger RNA;MicroRNAs;Modeling;Molecular;mouse model;Mus;nephron progenitor;Nephrons;new therapeutic target;novel therapeutic intervention;Obesity;Output;overexpression;Pathologic;Pathway interactions;Persons;pleiotropism;Polycystic Kidney Diseases;Population;pre-clinical;Predisposition;Prevalence;Process;Profibrotic signal;Regulation;Renal dialysis;renal epithelium;repaired;response;response to injury;Role;Signal Pathway;Testing;Tubular formation;United States;Ureteral obstruction;Work

PROJECT_TITLE: Regulation of tubulointerstitial crosstalk by microRNAs in renal fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-W(05)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE Over the past several years, a number of new molecular technologies have been developed that can modify both the DNA and RNA within living cells, many of which have been adapted from naturally occurring systems or enzymes. This project aims to computationally mine natural diversity for enzymes that can programmably recognize RNA sequences, characterize these enzymes to understand how they work, and use them as the basis for the development of new molecular tools for making precise changes to RNA sequences and for marking specific cell types that express a targeted RNA transcript. These tools can be used by other researchers to study many aspects of human biology and disease as well as be applied in the future for therapeutic uses, which we aim to demonstrate the feasibility of in this work.

PI_NAMEs: ZHANG, FENG  (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Acute;Adopted;base;Binding;Biochemical;Bioinformatics;Biological Sciences;Biology;Brain;Cell Line;cell type;Cells;Clinic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;computational pipelines;Deaminase;Development;Disease;disease model;DNA;Engineering;Enzymes;Evolution;experience;functional outcomes;Future;gene therapy;Genetic Diseases;Genetic Transcription;genome editing;Goals;Human Biology;human disease;Image;imaging platform;improved;in vivo;Kinetics;knock-down;liver injury;Mammalian Cell;microbial;Mining;Modification;Molecular;Molecular Biology;Molecular Conformation;mouse model;Mus;Mutation;neurodevelopment;Neurodevelopmental Disorder;Noise;novel;novel strategies;Orthologous Gene;Population;preference;Protein Engineering;Proteins;reconstitution;Recovery;Research;Research Personnel;Rett Syndrome;RNA;RNA Editing;RNA Sequences;RNA Stability;RNA-Binding Proteins;Role;Route;sensor;Signal Transduction;Specificity;Structure;Syndrome;System;Technology;technology development;Testing;Therapeutic;therapeutic genome editing;Therapeutic Uses;Tissues;tool;Transcript;transcriptome;Variant;Viral Vector;Work

PROJECT_TITLE: Advancing programmable RNA-targeting tools for research and therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-B(50)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunization;Immunotherapy;Nanotechnology;Orphan Drug;Pancreatic Cancer;Rare Diseases;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative Hundreds of clinical studies against a wide spectrum of cancers have resulted in the approval of just three therapeutic cancer vaccines, including Provenge®, which extends survival among men with prostate cancer by 2 to 3 months without inducing actual cancer regression or objective responses. The proposed platform has the potential to transform the way immune protection against cancer is generated. By introducing into the personal T-cell repertoire engineered T-cell receptors (TCRs) that optimally bind the most prevalent vaccine epitope, robust T-cell immunity could be reliably induced in a diverse human population independent of each individual's preexisting TCR repertoire.

PI_NAMEs: STEPHAN, MATTHIAS  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: 3-Dimensional;activated protein C receptor;Adjuvant;Affinity;Age;anti-cancer;Antibodies;antigen-specific T cells;Antigens;Antitumor Response;arm;B-Lymphocytes;Binding;bioinformatics tool;Biomedical Engineering;cancer cell;cancer immunotherapy;Cancer Patient;cancer regression;cancer type;Cancer Vaccine Related Development;Cancer Vaccines;CD28 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Chimeric Proteins;Clinic;clinical efficacy;Clinical Research;clinically relevant;Clone Cells;Data;Databases;design;Disease;engineered T cells;Engineering;Ensure;Epitopes;experience;fighting;Frequencies;Gene Modified;Genes;Goals;Homeostasis;Human;Immune;Immune response;Immune system;Immunity;Immunization;Immunize;immunological status;Immunologist;immunoregulation;improved;In Situ;Individual;Injectable;Intramuscular;Knowledge;KPC model;Ligands;Lymph;Lymphocyte;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Measures;Memory B-Lymphocyte;men;mesothelin;Methods;MHC Class II Genes;multidisciplinary;Mus;nanoparticle;nanoparticle delivery;nanoparticle drug;nanopolymer;neoantigens;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;Patients;Peripheral;Persons;Pharmaceutical Preparations;Phenotype;Physicians;Plasmids;Population;programs;Provenge;Reagent;receptor;Research;Research Proposals;response;Safety;Self Tolerance;side effect;Specificity;Survival Rate;System;T cell receptor repertoire sequencing;T cell response;T memory cell;T-Cell Receptor;T-Cell Receptor Genes;T-cell receptor repertoire;T-Lymphocyte;Techniques;Technology;technology platform;Testing;Therapeutic;Transgenes;Translations;tumor;Tumor Antigens;Tumor Escape;Tumor Immunity;Vaccine Antigen;vaccine failure;Vaccines;virtual;Wilms Tumor Suppressor 1

PROJECT_TITLE: Rational in situ programming of cancer vaccine-responding T-cell clones

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Data Science;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: PROJECT NARRATIVE Treatment options for people with co-occurring opioid and stimulant use disorders are limited, partially because this group is inadequately represented in treatment efficacy evaluations. The proposed research uses a novel data-fusion approach to translate narrowly-focused clinical trial results to broader, representative populations with co-occurring opioid and stimulant use disorders. This study will demonstrate the effectiveness of treatments for real-world patients with these co-occurring substance use disorders; clinicians, researchers, policymakers, and other stakeholders may use results to select treatments that improve the health of people using more than one substance.

PI_NAMEs: COOK, RYAN  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Abstinence;accountable care organization;addiction;Address;Adult;Age;Aging;Amphetamines;Area;attributable mortality;automobile accident;Award;Back;Benchmarking;Big Data;career;Cessation of life;Clinical;Clinical Treatment;Clinical Trials;Clinical Trials Network;clinically relevant;Communication;Complex;contingency management;Counseling;Data;Data Analyses;Data Element;data fusion;Data Science;Data Sources;Drug abuse;Drug usage;Education;effective therapy;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;efficacy evaluation;Electronic Health Record;Emergency department visit;Enrollment;Epidemiology;ethnic minority;Evidence based treatment;Exclusion;Exercise;Feedback;Funding;Future;Goals;Grant;Health;Health system;Heroin;Hospitalization;Hospitals;illicit opioid;improved;Income;Individual;Informatics;informatics training;innovation;insight;Instruction;interest;Intervention;Knowledge;Leadership;Machine Learning;Mathematics;Medicine;Methods;Modeling;mortality;motivational enhancement therapy;National Institute of Drug Abuse;Natural Language Processing;novel;Opioid;opioid epidemic;opioid overdose;opioid use;opioid use disorder;optimal treatments;Oregon;Outcome;Overdose;overdose death;Participant;patient population;Patient Representative;Patients;Persons;Pharmaceutical Preparations;Policies;Policy Maker;polysubstance use;Population;prescription opioid;psychiatric comorbidity;psychosocial;Race;racial minority;Randomized, Controlled Trials;Recommendation;recruit;Research;Research Personnel;Research Proposals;Sampling;Science;Selection for Treatments;Severities;sex;skills;Source;Specificity;statistics;Stimulant;stimulant use;stimulant use disorder;Substance Use Disorder;substance use treatment;Surveys;synthetic opioid;System;Target Populations;Techniques;Translating;treatment effect;Treatment Effectiveness;Treatment Efficacy;treatment strategy;treatment trial;trend;United States;Universities;Writing

PROJECT_TITLE: Transporting treatment effects from clinical trials to real-world populations with co-occurring opioid and stimulant use disorders

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

PHR: PROJECT NARRATIVE: Influenza A virus (IAV) is a serious respiratory pathogen, which poses an ongoing pandemic threat. Our research will focus on engineering new “universal" vaccines for influenza with the potential to elicit broad and cross-reactive immune responses against seasonal and pandemic viruses by (i) selecting highly conserved IAV immunogens and combining them within a single vaccine, (ii) increasing the immune recognition of these immunogens by incorporating molecular adjuvanting approaches, and (iii) finally by delivering optimized antigen expression cassettes using novel adenoviral vectored vaccines with low seroprevalence in humans.

PI_NAMEs: COUGHLAN, LYNDA  (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: Adenovirus Vector;Adjuvant;Adoptive Transfer;Antibodies;Antibody Response;Antigen Targeting;antigen-specific T cells;Antigens;B-Lymphocytes;Benchmarking;Binding;Bronchoalveolar Lavage;CD3 Antigens;CD8B1 gene;Cells;Cellular Immunity;cesium chloride;Clinical;CMV promoter;Cold Chains;comparative;coronavirus pandemic;cost;cost effective;cross reactivity;cytokine;Data;delivery vehicle;DNA cassette;Dose;draining lymph node;Effectiveness;efficacy evaluation;efficacy testing;egg;emerging virus;Engineering;enhanced green fluorescent protein;Enzyme-Linked Immunosorbent Assay;Epidemic;Epitopes;Equity;exosome;extracellular vesicles;Female;Funding;Hemagglutinin;homologous recombination;Human;human pathogen;Humoral Immunities;Immune;Immune response;Immune Sera;Immune system;Immunity;Immunization;immunogenic;immunogenicity;Immunoglobulin A;Immunoglobulin G;Immunologics;In Vitro;in vivo;Individual;Infiltration;Inflammation;Influenza A virus;influenza virus vaccine;influenzavirus;innovation;innovative technologies;Intramuscular;Investments;Lead;Lung;lung histology;Lymphocyte;male;manufacture;Measures;Mediating;Membrane;Membrane Glycoproteins;Modeling;Molecular;Morbidity - disease rate;Mucous Membrane;Mus;Neuraminidase;neutralizing antibody;novel;Nucleoproteins;Outcome;pandemic disease;pandemic potential;pandemic preparedness;pandemic virus;particle;pathogen;Peptides;Phenotype;Phylogenetic Analysis;Play;Population;pre-clinical;preclinical evaluation;Process;Production;Proteins;PTPRC gene;Publishing;Pulmonary Pathology;Readiness;Regimen;Regulation;Research;respiratory pathogen;response;Role;Route;Safety;seasonal influenza;Seasons;Seroprevalences;Serum;Spleen;Stains;System;T-Lymphocyte;Testing;Ultracentrifugation;universal influenza vaccine;universal vaccine;Vaccinated;Vaccination;Vaccine Antigen;vaccine evaluation;vaccine platform;vaccine safety;Vaccines;Validation;Variant;vector;vector vaccine;Viral;Viral Antigens;Virus;Work;Zoonoses

PROJECT_TITLE: Combining innovative molecular adjuvanting approaches with novel adenoviral vector delivery to generate a universal influenza vaccine


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: AMES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: Individualized medicine in the future will need to know exactly what specific mechanisms are affected by each individual disease mutant. This project will develop that information from the computational assessments of the effects of any possible mutation by building upon the knowledge that will be mined from the large number of genome sequences, interpreted in terms of functional proteins. The results will impact the selection of drugs for individual patients, the design of more effective drugs developed by narrowing the focus to the specific parts of a targeted protein that will be identified as being responsible for adversely affecting mechanism. The project will provide quantitative predictors of the potential adverse effects of mutants on specific mechanisms and will organize relevant data and predictions into readily accessible databases, to provide important new information to the practitioners of individualized medicine.

PI_NAMEs: JERNIGAN, ROBERT L (contact);KLOCZKOWSKI, ANDRZEJ

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Adverse effects;Affect;Amino Acid Sequence;Amino Acid Substitution;Amino Acids;Artificial Intelligence;Back;Behavior;Binding;Binding Proteins;Binding Sites;Cell Physiology;Characteristics;Classification;Clinical;Complex;Computer software;cost;Data;Data Analyses;data mining;Databases;design;Detection;Disease;disease phenotype;Drug Design;drug development;Drug Targeting;Environment;experience;Family;feature selection;Foundations;Future;Genetic Variation;Genome;genome sequencing;human disease;Impairment;improved;Individual;individual patient;individualized medicine;innovation;Knowledge;large datasets;Learning;Literature;Machine Learning;machine learning algorithm;Methods;Missense Mutation;Molecular;mutant;Mutation;Nature;Normal Range;novel;Organism;Outcome;Output;Patients;Pharmaceutical Preparations;Phenotype;Positioning Attribute;Predisposition;Probability;Property;Protein Dynamics;protein function;protein structure;Proteins;Quantitative Evaluations;random forest;Reporting;Scientific Advances and Accomplishments;screening;Sequence Alignment;Severities;Site;Solid;Specificity;Structure;Testing;tool;Training;Translating;user friendly software;Variant

PROJECT_TITLE: Novel Use of Genome Information to Understand Mutations


NIH_SPENDING_CATS: Genetics;Microbiome

ORG_CITY: WORCESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Bacteria live everywhere as members of multispecies communities, and the activities in these microbiomes can have profound impacts on their hosts as well as the environment. This research focuses on discovering the chemical and genetic mechanisms bacteria use to interact with one another. Gaining a molecular understanding of these cell-cell interactions will provide us with a better understanding of microbial ecology as well as chemical tools to manipulate bacterial behavior in natural microbiomes.

PI_NAMEs: SHANK, ELIZABETH ANNE (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Animals;Antibiotics;Bacillus subtilis;Bacteria;bacterial community;Bacterial Physiology;Behavior;Biological Models;Cell Communication;Cells;Chemicals;Communities;Complex;Cues;Development;Ecology;Environment;extracellular;Genetic;Genetic Transcription;Heterogeneity;interest;Intervention;member;Metabolic;Metabolism;Microbe;microbial;Microbial Biofilms;microbial community;microbiome;Molecular;National Institute of General Medical Sciences;Nature;Phylogenetic Analysis;Physiology;Planets;Plants;Play;Prevalence;Probiotics;Research;Role;secondary metabolite;Shapes;Signal Transduction;Soil;Source;Spatial Distribution;Specificity;Swimming;System;Therapeutic;tool

PROJECT_TITLE: Investigating the molecules and mechanisms of bacterial cell-cell interactions

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Disease

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE This research will develop and validate advanced multiparametric imaging technology which combines magnetic resonance imaging, cytometry and elastography (MR-ICE) to substantially advance noninvasive characterization of the spectrum histopathologic changes in patients with nonalcoholic fatty liver disease. Success of the proposed research will provide critically needed noninvasive technology for identifying patients who have a high risk of developing advanced disease in the nonalcoholic steatohepatitis spectrum, allowing early therapeutic intervention.

PI_NAMEs: YIN, MENG  (contact)

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: 3-Dimensional;Address;Adult;advanced disease;Affect;Assessment tool;Biological Markers;biomarker validation;Biopsy;cell injury;Cell Size;Chemical Shift Imaging;Cirrhosis;Clinical;clinical practice;Clinical Research;Clinical Trials;Cytometry;design;Development;Diagnosis;Diagnostic;Diet;Diffusion;Disease;Elasticity;elastography;Ensure;Evaluation;Evolution;Fatty acid glycerol esters;Fibrosis;Frequencies;Goals;Guidelines;Hepatic;hepatocellular injury;Hepatocyte;high risk;Histologic;Histopathology;Hybrids;Image;imaging biomarker;imaging modality;Imaging technology;in vivo;in vivo imaging;Inflammation;Intercellular Fluid;Intervention;Iron;Knowledge;Liver;liver biopsy;Liver diseases;Liver Fibrosis;liver inflammation;liver stiffness;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Measurement;mechanical properties;Mechanics;Methods;Modeling;Modification;Modulus;Monitor;Motion;multiparametric imaging;non-alcoholic fatty liver disease;non-invasive imaging;nonalcoholic steatohepatitis;novel;Patients;Performance;Phase;preclinical study;Prevalence;primary endpoint;Protocols documentation;Radial;Rattus;reconstruction;Research;research clinical testing;Research Personnel;Risk;Scheme;secondary endpoint;Severities;Signal Transduction;simple steatosis;Staging;Statistical Models;Steatohepatitis;Structure;success;Techniques;Technology;Testing;Therapeutic Intervention;Tissues;Training;treatment effect;Treatment Efficacy;United States;vector;virtual;viscoelasticity;Water;Work

PROJECT_TITLE: Comprehensive noninvasive assessment of liver histopathology in nonalcoholic fatty liver disease (NAFLD) via magnetic resonance imaging, cytometry and elastography (MR-ICE)

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PROJECT NARRATIVE The system comprising the bacterium Escherichia coli and its virus, bacteriophage lambda, serves as a simple paradigm for the way gene regulation drives the choice between alternative cellular fates. The outcome of the proposed work will be a predictive, quantitative description of gene regulation and fate choice in the system, at the single-cell level. The conceptual and experimental tools developed in this work will further our understanding of how gene regulation drives cell-fate choices in higher systems, and ultimately, in the context of human health and disease.

PI_NAMEs: GOLDING, IDO  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Awareness;Bacteria;Bacteriophage lambda;Bacteriophages;Behavior;behavior prediction;Biological;Biology;Biophysics;cell behavior;Cell Death;Cell Differentiation process;Cell Physiology;Cells;Complex;Cytolysis;Disease;Embryo;emerging antibiotic resistance;Environment;Escherichia coli;Escherichia coli Infections;Event;Exhibits;Gene Expression;Gene Expression Regulation;Genetic;Goals;Health;Heterogeneity;Human;Image;Individual;Individuality;Infection;Lysogeny;Maps;Modeling;Molecular;Noise;Organism;Outcome;Phenotype;Process;Property;Proteins;Research;Role;Signal Transduction;single molecule;Statistical Distributions;success;System;tool;Viral;Virus;Work

PROJECT_TITLE: ILLUMINATING CELLULAR INDIVIDUALITY THROUGH BACTERIOPHAGE INFECTION

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative  The Research Domain Criteria (RDoC) provides the basis for research into the brain system dysfunctions that are responsible for mental illness, but the existing RDoC framework has serious limitations that prevent it from being fully effective in driving research. We propose to use a combination of large-scale online behavioral testing and extensive MRI scanning of individuals performing a set of psychological tasks that are relevant to a set of mental processes (attention, working memory, and cognitive control) that are known to play a key role in mental illness. This approach will allow us to extend the RDoC framework to more precisely map from the mental processes involved in mental illness to brain circuits.

PI_NAMEs: POLDRACK, RUSSELL A (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Address;Algorithms;Animal Experimentation;Animals;Atlases;Attention;Automobile Driving;Behavior;behavior measurement;behavior test;Behavioral;behavioral study;Brain;Brain imaging;Cognitive;cognitive control;cognitive neuroscience;cognitive system;cognitive task;Collection;Consultations;Data;Dimensions;Disease;Education;Equation;experience;Experimental Designs;Exposure to;Factor Analysis;Functional disorder;Functional Magnetic Resonance Imaging;Human;Individual;Informal Social Control;large scale data;Link;Literature;Logic;Maps;Measurement;Measures;Mental disorders;Mental Health;Mental Processes;mental set;Methods;Modeling;MRI Scans;Multivariate Analysis;National Institute of Mental Health;neural;neural circuit;neuroimaging;Outcome;Patient Self-Report;Performance;Phenotype;Play;prevent;programs;psychologic;Psychopathology;Recording of previous events;Research;Research Domain Criteria;Research Personnel;Research Project Grants;response;Sampling;Scanning;Series;Short-Term Memory;Specific qualifier value;Structural Models;Structure;substance use;Support System;Surveys;System;Techniques;Testing;Training;Validation

PROJECT_TITLE: Data-driven validation of cognitive RDoC dimensions using deep phenotyping

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative Identifying ways to improve CD8 T cell responses to viral and infection and cancer is a goal of immediate importance. We recently identified that the cytokine, IL-27, promotes expansion and CD8 T cell responses during persistent viral infection. In the current proposal we will investigate the cellular sources of IL-27, how this cytokine sustains CD8 T cells survival and whether IL-27 signaling is essential for sustaining CD8 T cell responses to anti-PD-1/L1 therapy during persistent viral infection and cancer; the ultimate goal of these studies is to understand how IL-27 promotes optimal CD8 T cell responses in these disease states.

PI_NAMEs: TEIJARO, JOHN ROSS (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Acceleration;Animal Model;anti-PD-1;anti-PD-1/PD-L1;anti-PD-L1 therapy;anti-PD1 therapy;antigen-specific T cells;Antigens;Antitumor Response;Apoptosis;Apoptotic;Biochemical;Biological Response Modifiers;Biology;BLR1 gene;Cancer Model;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;Cell Death;Cell division;Cell Physiology;Cell Survival;Cells;Chronic;chronic infection;Coupled;cytokine;Cytoprotection;Disease;disorder control;Diving;Endowment;exhaust;exhaustion;Genetic;Goals;HIV/HCV;IFNAR1 gene;Immune;immune checkpoint blockade;Immunotherapy;improved;Infection;inflammatory milieu;Interferons;IRF1 gene;Knowledge;LoxP-flanked allele;Lymphocytic choriomeningitis virus;Malignant Neoplasms;Memory;Methods;Modality;Modeling;Molecular;Mus;Patients;Population;prevent;Process;Production;programmed cell death protein 1;Proliferating;Proteomics;Publishing;receptor;Reporter;Reporting;Resistance development;response;Role;self-renewal;Signal Induction;Signal Pathway;Signal Transduction;Source;stem;Surface;T cell differentiation;T cell response;T-Lymphocyte;TCF Transcription Factor;Testing;transcription factor;tumor;Viral;Viral Cancer;Virus;Virus Diseases;Work

PROJECT_TITLE: The role of IL-27 in sustaining the exhausted CD8 T cell response to persistent infection and cancer.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE People with HIV are living longer in Latin America with widespread access to antiretroviral therapy increasing risk of developing HIV-associated neurocognitive disorder (HAND), present in up to 50% of people with HIV worldwide. Emerging data, including our preliminary data, highlight that identifying HIV-associated neurocognitive disorders in Latin America is challenging given limited resources and specialists. I propose to evaluate a simple multi-modal platform for screening and predicting HAND in two large HIV clinics in Lima, Peru that can be utilized to assess the impact of HAND in Latin America.

PI_NAMEs: DIAZ, MONICA MARIA (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Abbreviations;Affect;Age;AIDS prevention;Alzheimer disease screening;Alzheimer's Disease;antiretroviral therapy;Anxiety;Area;Behavioral;bilingualism;Biometry;brain health;care providers;career development;Chronic;Clinic;Clinical;Clinical Assessment Tool;Clinical Research;Cognition Disorders;Cognitive;cognitive performance;cognitive testing;Country;Data;design;Development;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic tool;disorder risk;Early Diagnosis;Early identification;Early Intervention;Education;Employment;Environment;Evaluation;experience;Financial Hardship;flexibility;Focus Groups;Frequencies;Future;Goals;Grant;HIV;HIV diagnosis;HIV Seronegativity;HIV-associated neurocognitive disorder;Hour;Impaired cognition;implementation framework;implementation science;improved;Individual;Infection;International;Interview;Latin America;Latino Population;low and middle-income countries;low health literacy;Medical;medical schools;Mental Depression;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;modifiable risk;Morbidity - disease rate;multidisciplinary;multimodality;neurocognitive disorder;Neurologist;Neuropsychological Tests;Neuropsychology;North Carolina;novel;Nurses;Older Population;Outcome;Paper;patient oriented;Patients;Persons;Peru;Peruvian;Physicians;Pilot Projects;Population;Poverty;Predictive Factor;predictive modeling;Prospective cohort;Prospective Studies;Protocols documentation;Qualitative Research;Reporting;Research;Research Methodology;Research Personnel;Resources;Risk;Risk Factors;Scientist;screening;Screening procedure;sex;Site;skills;social determinants;social health determinants;socioeconomic disparity;socioeconomics;Spanish/English;Specialist;Specificity;Statistical Models;Syphilis;systematic review;Tablets;Testing;Time;tool;Training;Tuberculosis;Underserved Population;United States National Institutes of Health;Universities;Validation;Work

PROJECT_TITLE: Improving identification of HIV-associated neurocognitive disorder (HAND) in Latin America: A multimodal approach to HAND in Peru

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Project Narrative This application requests funds to support post-DVM PhD training in translational biomedical research. Well- trained veterinary scientists bring unique knowledge about comparative biology that significantly contributes to the clinician scientist workforce and aids studies of human health and disease.

PI_NAMEs: DEAN, GREGG A;SANTANGELO, KELLY S (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TITLE: Biomedical Research Training for Veterinarians


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Neurosciences;Precision Medicine

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: The proposed research will develop new data modeling and analysis techniques to extract clinically useful information from brain activity measurements of patients with neurological injuries. These techniques will allow clinicians to make real-time predictions of patient outcomes and design earlier and more targeted treatments, using non-invasive technologies. Thus, the proposed research will improve the care of individual patients and enhance clinical efficiency, including in under-resourced healthcare settings.

PI_NAMEs: CHING, SHINUNG  (contact);GUERRIERO, REJEAN M;KUMMER, TERRANCE T

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Address;Adult;Age;Agonist;Alpha Rhythm;Architecture;Attention;Automation;Behavior;Biological Markers;Biological Models;Biophysics;Brain;brain control;brain electrical activity;Brain Injuries;Caring;Categories;Childhood;Clinical;clinical application;clinically actionable;Cognitive;Cognitive deficits;cognitive function;Cognitive Science;cohort;Coma;computational platform;Computer Analysis;Computing Methodologies;connectome;Coupled;Critical Care;Critical Illness;Data;Data Analyses;data modeling;Data Set;Death Rate;design;Development;Disease;dynamic system;Economic Burden;Electroencephalography;Electrophysiology (science);Engineering;Exhibits;falls;Feedback;functional outcomes;Goals;health care settings;Health Resources;Heterogeneity;heterogenous data;high dimensionality;High Prevalence;high risk population;Human;human data;human model;Hypoxia;Impairment;improved;in silico;Individual;individual patient;individual variation;Individuality;Informatics;Injury;innovation;insight;Intensive Care;Intervention;Intracranial Hypertension;Link;Measurement;Measures;Medicine;Memory;Mental disorders;Methods;Modality;Modeling;Monitor;Nervous System Disorder;Nervous System Trauma;Neurologic;Neurologic Deficit;Neurons;Neurosciences;novel;novel strategies;outcome prediction;Pathway interactions;Patient Care;patient response;Patient-Focused Outcomes;Patients;Pattern;personalized medicine;pharmacologic;Physiological;Population;predicting response;predictive modeling;Predisposition;Prospective Studies;Research;resource guides;Retrospective Studies;Seizures;signal processing;Signal Transduction;Techniques;Technology;theories;Therapeutic;Time;Translations;Traumatic Brain Injury;treatment response;Variant;Work

PROJECT_TITLE: SCH: Tracking Individual Brain State Trajectories: Methods and Applications in Precision Neurocritical Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: ATLANTA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Narrative  Respiratory syncytial virus is a major health threat to infants, in particular when born prematurely, with underlying respiratory conditions or congenital heart disese, older adults, and the immunocompromised. A lack of effective vaccines and efficacious antiviral therapeutics creates an urgent clinical need for the development of novel therapeutics that improve RSV disease management and control virus spread. This project will advance two innovative RSV inhibitor classes towards formal preclinical development.

PI_NAMEs: PLEMPER, RICHARD K. (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: 3-Dimensional;5 year old;Address;Adherence;Adult;Advanced Development;Age;Air;airway epithelium;Anabolism;analog;Animal Model;Anti-viral Agents;anti-viral efficacy;Antibody Therapy;Biochemical;Biological Assay;Biological Availability;Bronchiolitis;Cell Culture Techniques;Cells;Child;Clinical;clinical candidate;Communicable Diseases;Companions;Complex;congenital heart abnormality;cytotoxicity;Data;deep sequencing;design;Development;Disease;Disease Management;disorder control;Docking;Dose;drug discovery;Drug Kinetics;Drug or chemical Tissue Distribution;Drug Screening;Elderly;Eligibility Determination;Ensure;Epidemic;experience;Failure;Foundations;Future;Generations;Goals;Health;Heart;high risk;high throughput screening;Hospitalization;Hour;Human;human tissue;Immunocompromised Host;immunoprophylaxis;improved;in vivo;indexing;Individual;Infant;Infection;inhibitor;innovation;insight;Lead;Life;Liquid substance;Lung;Measurement;Mediating;medical attention;Mitochondria;Modeling;Molecular;Molecular Conformation;mouse model;Mus;nanomolar;novel;novel therapeutics;Nuclear;older adult;Oral;Organoids;Pathogenesis;patient population;Patients;pediatric patients;Performance;personalized approach;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Physiological;Pilot Projects;Plasma;Polymerase;Population;pre-clinical;preclinical development;premature;Preparation;prevent;Process;Program Development;programs;promoter;Property;Quantitative Structure-Activity Relationship;Reporter;Research;Resistance;Resistance profile;respiratory;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;respiratory virus;Ribonucleosides;Risk;risk mitigation;RNA chemical synthesis;RNA-Directed RNA Polymerase;Safety;scaffold;Seasons;serial imaging;Series;simulation;Solid;Structure;Technology;Testing;Therapeutic;Time;Tissue Model;Tissues;Transcript;Triage;tripolyphosphate;United States;Uridine;Vaccines;Validation;Viral;Viral load measurement;Viral Load result;Virus;Virus Diseases;Virus Inhibitors;Vulnerable Populations;Work

PROJECT_TITLE: Polymerase Inhibitors of Respiratory Syncytial Virus

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision

ORG_CITY: AMHERST

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: NARRATIVE The central diagnostic finding in Fuchs endothelial corneal dystrophy are progressive guttae—excrescences in the extracellular matrix of the corneal endothelium that contribute to vision loss and corneal endothelial cell loss. This project will investigate the extracellular matrix changes that occur when corneal endothelial cells are exposed to stress and will investigate how non-diseased corneal endothelial cells respond to extracellular matrix prepared from stressed cells. Extracellular matrix changes may be some of the first changes that occur in the pathophysiology of Fuchs endothelial corneal dystrophy and these studies will help identify potential pathways to target for future therapeutics.

PI_NAMEs: PATEL, SANGITA  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Actins;Affect;Air;Basement membrane;Bilateral;Biological Models;Blindness;Cattle;Cell Adhesion;Cell Culture Techniques;Cell Death;cell growth;Cell Physiology;Cell Respiration;Cell secretion;Cell Survival;Cells;Cellular Stress;clinical diagnostics;Corneal Endothelium;Cytoskeleton;Data;Deposition;Descemet's membrane;Development;Disease;Disease Pathway;Drops;drug discovery;Drug Targeting;Endothelial Cells;Environment;Experimental Models;experimental study;Exposure to;Extracellular Matrix;Fibronectins;Fuchs' Endothelial Dystrophy;Functional disorder;Future;Generations;Genetic;Glucose;Glycolysis;Growth;Human;In Vitro;Incubators;Individual;Injection of therapeutic agent;insight;interest;Keratoplasty;Knowledge;Measurement;Measures;Membrane;Metabolic;Metabolic Pathway;metabolic profile;Metabolism;Methods;Microfilaments;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modification;Monitor;Morphology;novel;Oxygen;Pathogenesis;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Proteomics;Respiration;Role;Sampling;Signs and Symptoms;Smoking;Specimen;Stress;stressor;Structure;Study models;System;TCF7L2 gene;Testing;Therapeutic;Tissue Engineering;tool;United States;UV Radiation Exposure;Vision

PROJECT_TITLE: Corneal Endothelium – Extracellular Matrix Interactions

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Mental Health;Neurosciences

ORG_CITY: DAYTON

ORG_NAME: UNIVERSITY OF DAYTON

PHR: PROJECT NARRATIVE The current project will establish the significance of the calcium-handling protein phospholamban in the thalamic reticular nucleus, a brain region implicated in the pathophysiology of various neurodevelopmental disorders. The proposed research is highly relevant to the mission of the NIH and public health; gaining insights into the intricate calcium-cycling processes that operate in the thalamic reticular circuitry may lead to the development of novel pharmacotherapeutic approaches to help manage these debilitating and costly brain disorders.

PI_NAMEs: PITYCHOUTIS, POTHITOS  (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Ablation;Address;Affect;Antibodies;Applications Grants;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;Award;Behavior;Behavioral;behavioral phenotyping;Bioinformatics;Biology;Brain;Brain Diseases;Brain region;Ca(2+)-Transporting ATPase;Calcium;calcium indicator;Calcium Signaling;Cardiac;Cardiovascular system;Cell Nucleus;Cells;Complex;cost;Cre-LoxP;Data;Dendrites;Detection;Development;endophenotype;Endoplasmic Reticulum;experimental study;Exposure to;Fiber;field study;fluorophore;Functional disorder;gamma-Aminobutyric Acid;gene network;Genetic;Genetic Transcription;Goals;graduate student;Heart;High Pressure Liquid Chromatography;High-Throughput RNA Sequencing;Homeostasis;Hyperactive behavior;Hyperactivity;Image;imaging approach;Impulsive Behavior;Impulsivity;in vivo;in vivo calcium imaging;innovation;insight;Knockout Mice;laboratory curriculum;Maps;Mediating;Methodology;Mission;Molecular;molecular dynamics;Motor;Motor Activity;mouse model;Mus;neural circuit;Neurobiology;neurochemistry;Neurodevelopmental Disorder;Neurons;neurophysiology;Neurosciences;Neurosciences Research;novel;novel therapeutics;Parvalbumins;patch clamp;Pathway interactions;Periodicity;phospholamban;Photometry;Physiology;Population;preservation;Process;Property;Prosencephalon;Proteins;Protocols documentation;Public Health;Reaction Time;Reagent;Regulation;Research;Research Personnel;response;Role;Schizophrenia;Science;scientific literacy;selective expression;Sensory;Signal Transduction;Sleep;Solid;Structure;Students;Testing;Thalamic structure;Thinness;tool;transcriptome sequencing;transcriptomic profiling;transcriptomics;Transgenic Mice;Transgenic Organisms;undergraduate student;United States National Institutes of Health;Universities;Viral

PROJECT_TITLE: Deciphering the Thalamic Reticular Functions of Phospholamban

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Disability Research;Mental Health;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: DUQUESNE UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE This project seeks to overcome a widely held but inaccurate assumption that has long plagued the study of the stuttering condition: that a surface view of stuttering severity can (a) identify adults who stutter at risk for broader impact and (b) accurately specify speech neurophysiology in adults who stutter. Both of these assumptions will be directly challenged by consideration of sub-group differences in cognitive-affective reactions measured via validated nationally representative surveys and by measuring speech neurophysiology in situ in realistic face-to- face communicative environments using functional near-infrared spectroscopy. The identification of adults who stutter at-risk for broader impact and the specification of speech neurophysiology in real-world communication will directly support improvements in the assessment and treatment of the disorder, further specify pathophysiology of stuttering, and reduce the burden of living with the condition in the roughly three million individuals in the United States who stutter.

PI_NAMEs: TICHENOR, SETH  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Accounting;Adult;Affective;Anxiety;Area;Attention;Behavior;behavior measurement;Behavioral;Characteristics;Clinical;Clinical Skills;Cognitive;Communication;comparison group;Compensation;coping;Correlation Studies;Data;Data Analyses;Death Rate;Disease;Disparate;Education;effective therapy;Employment;Environment;experience;Feeling;Feeling suicidal;Frequencies;Functional disorder;functional near infrared spectroscopy;General Population;Goals;hemodynamics;Impairment;improved;In Situ;Individual;Interview;Investigation;Knowledge;Language;Left;Life;Lived experience;Measurement;Measures;Mental Depression;Motor;motor control;motor deficit;neural;neurophysiology;Occupations;Outcome;Participant;Patient Self-Report;Pattern;Personal Satisfaction;personalized intervention;Persons;Production;Reaction;Reading;Reduce health disparities;Research;Research Activity;Research Personnel;response;Risk;Risk Factors;rumination;Service provision;Severities;social anxiety;Social isolation;social stigma;Specific qualifier value;Speech;Stress;Students;Stuttering;Subgroup;Surface;Surveys;targeted treatment;Testing;Thinking;Time;United States;Universities;virtual;Work

PROJECT_TITLE: Specifying Neurophysiology and Predicting Real-world Impact in Stuttering

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Complementary and Integrative Health;Drug Abuse (NIDA only);Mental Health;Patient Safety;Substance Misuse

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative With the rapid increase in medicinal cannabis use, there is an urgent need to identify patients who are at-risk for cannabis use disorder, which can occur as an unintended adverse effect of using medicinal cannabis. Importantly, not all patients who use medicinal cannabis develop addiction or a pathological pattern of cannabis use (cannabis use disorder). This longitudinal study will collect new data on cannabis use in relation to health at micro (daily) and macro (follow-up over 2-years) time scales to understand the roles of tolerance and withdrawal (symptoms often experienced when taking medication as recommended) in likelihood of addiction among medicinal cannabis patients, and will identify risk factors for cannabis use disorder as a possible iatrogenic effect of using medicinal cannabis to inform clinical practice guidelines.

PI_NAMEs: CHUNG, TAMMY  (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: addiction;Address;Adverse effects;Age;alcohol and other drug;alcohol use disorder;Alcohols;Anxiety;Biological Markers;Cannabis;Cannabis policy;cannabis use behavior;cannabis withdrawal;Chronic;Clinical;Clinical Practice Guideline;Data;Data Collection;Development;Diagnosis;Dose;Drug Prescriptions;Drug usage;DSM-IV;DSM-V;Ecological momentary assessment;Exclusion;experience;Female;follow-up;Health;high risk;Iatrogenesis;Impairment;improved;innovation;insight;Intoxication;Legal Medicine;Link;Longitudinal Studies;male;marijuana use;marijuana use disorder;Measures;Medical Marijuana;Medicine;Mental Health;Modeling;Monitor;National Institute of Drug Abuse;neuroadaptation;Outcome;Pain;pain relief;Participant;Pathologic;Patient Recruitments;Patient Self-Report;patient subsets;Patients;Pattern;personalized intervention;Persons;Pharmaceutical Preparations;physical conditioning;Policy Research;Practice Guidelines;prevent;Process;Psychopathology;pulmonary function;Pulmonary function tests;Quality of life;Recommendation;Recording of previous events;Recreation;recruit;Regimen;Reporting;Research;Risk;Risk Factors;Role;Sampling;Severities;sex;Sex Differences;sleep quality;Spirometry;Strategic Planning;substance use;Substance Use Disorder;Surveys;Symptoms;Time;Urine;Visit;Vital capacity;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Cannabis effects on physical and mental health in medical cannabis patients

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Pain is the principal reason for seeking medical attention. It respects no boundaries, is not restricted to any one disease or medical discipline, is distributed across the life span and experienced by all irrespective of status (economic, educational, etc.) or gender. Many tissue insults lead to chronic pain states which are poorly managed because the mechanisms underlying pain are incompletely understood. Thus, there is a compelling need to enhance and broaden the training of the next generation of pain researchers.

PI_NAMEs: GOLD, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: KORN, STEPHEN J

PROJECT_TERMS: Clinical;Pain;Training

PROJECT_TITLE: Training in Mechanisms and Clinical Presentation of Pain


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE Black Americans experience significant mental health consequences due to race-related stress; yet, little is known about the psychological mechanisms through which race-related stress leads to negative outcomes and whether such mechanisms can be altered using brief, culturally-informed mindfulness interventions. To address this, we aim to investigate (a) if attention bias to threat – a novel, understudied transdiagnostic factor that reflects when one’s attention is disproportionately allocated to threatening stimuli – is such a mechanism in the race- related stress-mental health link, (b) if a brief, culturally-responsive mindfulness intervention can reduce attention bias to threat, and (c) if racial identity, a key individual difference factor, exacerbates race-related stress’s effects and amplifies the benefits of a culturally-informed intervention. To carry out this project, rigorous experimental designs and innovative eye-tracking methods in a Black community sample will be used, and findings from this project can inform the development of culturally anchored etiological and treatment models for this population.

PI_NAMEs: MEKAWI, YARA  (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Address;Adult;Affect;African American student;Anxiety;anxious;Area;Arousal;Attention;attentional bias;Biological;biological adaptation to stress;Black American;Black Populations;Black race;career;Communities;culturally appropriate intervention;Data;Data Reporting;design;Development;Diagnostic;Diagnostic Factor;Disadvantaged;Emotions;Esthesia;Etiology;experience;Experimental Designs;Exposure to;Fostering;health disparity;Individual;Individual Differences;innovation;interest;Interruption;Intervention;Link;Literature;Maintenance;marginalized community;Mental Depression;Mental Health;Mentorship;Methods;mindfulness;mindfulness intervention;mindfulness meditation;Modeling;novel;Outcome;Pathological anxiety;Pathway interactions;Patient Self-Report;personalized medicine;Population;post-traumatic stress;Process;psychologic;psychological symptom;Psychopathology;Public Health;Race;racial difference;racial identity;racial population;racism;recruit;Research;response;Risk;Sampling;Shapes;Stimulus;Stress;Structure;Symptoms;System;Testing;Thinking;Training;Treatment Effectiveness;undergraduate student;underserved community;visual tracking;Work

PROJECT_TITLE: Racism's Effect on Attention Bias to Threat: Testing a Brief Mindfulness Intervention for Black Americans

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE We propose a new program for Clinician-Scientist Research Education and Training in Otolaryngology at the University of Washington (UW). We provide structured and rigorous education to residents and medical students on how to conduct innovative and impactful research in several areas relevant to communication, including hearing, speech, language, balance, smell, voice, airway, and head and neck cancer. Our program combines intensive mentored research training, coursework, and workshops, plus instruction on professional development toward an academic career.

PI_NAMEs: RUBINSTEIN, JAY T.;STONE, JENNIFER S. (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Address;Applications Grants;Area;Award;Breathing;career;career development;career preparation;Clinical;clinical training;Communication;cost;Country;Dedications;design;Development;Development Plans;Disease;diversity and inclusion;Education;Education Projects;education research;Educational process of instructing;Educational workshop;Effectiveness;Elements;environmental enrichment for laboratory animals;Equilibrium;Evaluation;experience;Faculty;Feedback;Fellowship;Financial Support;Funding;Goals;Grant;Hand;Head and Neck Cancer;Head and Neck Surgery;Healthcare;Hearing;Hour;Human;Individual;innovation;Instruction;K-Series Research Career Programs;Knowledge;Language;leadership development;Learning;Literature;Manuscripts;Medical Students;Medicine;Mentors;Mentorship;Mission;National Institute on Deafness and Other Communication Disorders;next generation;novel;Oral;Otolaryngologist;Otolaryngology;Outcome;Participant;patient engagement;Patients;peer;peer networks;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Process;Program Description;programs;Public Health;Recording of previous events;Research;Research Activity;Research Design;Research Project Grants;Research Support;Research Training;Residencies;Resources;response;Rotation;Scientist;Secure;Series;skills;Smell Perception;Speech;Statistical Data Interpretation;Structure;Study Skills;success;support network;Time;Training;Training and Education;Training Programs;Universities;Vocational Guidance;Voice;Washington;Work;Writing

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Z (46)]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurofibromatosis;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative Neurofibromatosis type 1 is a genetic disorder, with an incidence of 1:3000, which can cause significant morbidity. Family members with the same NF1 mutation show variable disease features. We assembled a team to define changes in the genome that underlie variability and to test effects of changes in animalmodels.

PI_NAMEs: RATNER, NANCY  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Affect;Aging;Alleles;Animals;APC gene;Assessment tool;Benign;Biological Models;Biometry;Blood;Candidate Disease Gene;Cell Culture Techniques;Cells;Chicago;Child;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Collection;Data;Databases;de novo mutation;Dermal;Development;Diagnosis;Dideoxy Chain Termination DNA Sequencing;Disease;DNA;DNA analysis;exome;Family member;Fishes;G Protein-Coupled Receptor Signaling;Gene Expression Profiling;Genes;Genetic Diseases;Genome;Genomics;Germ Lines;Germ-Line Mutation;Histology;Homologous Gene;Human;human DNA;In Vitro;Incidence;Individual;Location;loss of function;MAP Kinase Gene;Mediating;member;Modeling;Morbidity - disease rate;mouse genetics;mouse model;multidisciplinary;Mus;Mutation;neurofibroma;Neurofibromatosis 1;NF1 gene;NFIX gene;novel;Ohio;Optic Nerve Glioma;Pathway interactions;patient population;Patients;Pediatric Hospitals;Peripheral Nerve Sheath Neoplasm;Phenotype;Plexiform Neurofibroma;Population Control;precision medicine;Proteins;Rapid screening;recruit;Recurrence;Research;Risk Assessment;risk stratification;risk variant;sample collection;Sampling;Schwann Cells;screening;Severity of illness;sex;Signal Transduction;Testing;Therapeutically Targetable;Time;tumor;Tumor Burden;tumor initiation;Twin Studies;Universities;Validation;Variant;Zebrafish

PROJECT_TITLE: Identification of germline modifiers of Neurofibromatosis type 1 tumors

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Microbiome;Nutrition;Pancreatic Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

PHR: PROJECT NARRATIVE Microbial metabolites have suggested to influence anti-tumor immunity and cancer treatment. This proposal will characterize the sources, mechanisms, and translational relevance of a minimally understood, high impact microbial metabolite, TMAO (trimethylamine N-oxide) in a lethal pancreatic ductal adenocarcinoma (PDAC).

PI_NAMEs: SHINDE, RAHUL SURESH (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Amines;anti-PD-1;anti-tumor immune response;antitumor effect;Antitumor Response;Automobile Driving;Bacteria;Betaine;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;chemotherapy;ChIP-seq;Choline;Clinical;clinically relevant;Data;Development;Diet;dietary;Dose;effector T cell;efficacy testing;Engineering;Enterococcus;Escherichia coli;exhaustion;Genetic Transcription;Genetically Engineered Mouse;Goals;gut microbes;gut microbiome;Immune;immune checkpoint blockade;Immuno-Chemotherapy;Immunotherapy;improved;Infiltration;Interferons;intraperitoneal;Levocarnitine;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;metabolomics;Microbe;microbial;microbiome;microbiome therapeutics;Modeling;Mus;novel;Organoids;Oxides;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Patients;Phenotype;Pre-Clinical Model;programs;Publishing;Research;Resistance;response;Series;Shapes;Signal Pathway;Signal Transduction;Source;STAT1 gene;STAT3 gene;STING agonists;T cell response;Testing;Toxic effect;transcription factor;treatment response;treatment strategy;tumor;Tumor Burden;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;Work

PROJECT_TITLE: Characterizing the sources, mechanisms, and translational relevance of microbial TMAO in driving anti-tumor immunity in pancreatic cancer.

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE  The Kansas IDeA Network of Biomedical Research Excellence (K-INBRE) is a network of Universities in Kansas and Oklahoma that augments the research infrastructure, training, research productivity, and career development of biomedical researchers and undergraduate students. The K-INBRE offers diverse programs and funding mechanisms to support researcher pipelines and careers, build research infrastructure, and enhance the competitiveness of Kansas biomedical researchers. The K-INBRE’s strength is its long-standing collaborative network and success in pipeline development for students, trainees, and faculty in biomedical research. K-INBRE operates through three Cores with foci in faculty and trainee mentoring, data science, and administration and execution of this longstanding Kansas IDeA program.

PI_NAMEs: WRIGHT, DOUGLAS E (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Award;base;Biomedical Research;career;career development;Career Mobility;Centers of Research Excellence;Clinical Sciences;Collaborations;Communication;Communities;Data Collection;Data Science;Data Science Core;Development;Doctor's Degree;Education;Education and Outreach;Educational Curriculum;Elements;Eligibility Determination;ethnic diversity;Evaluation;Faculty;Funding;Funding Mechanisms;Funding Opportunities;Geography;Grant;Health;Health Sciences;high school;improved;Incentives;Infrastructure;innovation;Institution;Interdisciplinary Study;Kansas;Knowledge;Link;Medical center;Mentors;Modernization;multidisciplinary;Oklahoma;Pilot Projects;Postdoctoral Fellow;pre-clinical;Productivity;Program Evaluation;Program Research Project Grants;programs;Research;Research Activity;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Research Support;Scholarship;Science;skill acquisition;skills;student participation;student training;Students;success;Technology;tool;Training;Training and Education;Training Programs;undergraduate research;undergraduate research experience;undergraduate student;United States National Institutes of Health;Universities;Wichita;Work

PROJECT_TITLE: Kansas IDeA Network of Biomedical Research Excellence 5

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-7 (IN)]