NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Substance Misuse;Telehealth;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

PHR: The prevalence of opioid use disorder (OUD) during pregnancy has quadrupled over the past decade, as have adverse maternal and neonatal health outcomes related to substance use. This research will test the effectiveness of a prenatal provider education and training program designed to facilitate provider adoption of evidence-based practices for the treatment of OUD during pregnancy. Findings from this research will provide high-quality evidence about how to increase evidence-based treatment for pregnant women with OUD and subsequent maternal and child health outcomes.

PI_NAMEs: JARLENSKI, MARIAN PATRICIA;KRANS, ELIZABETH E (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: addiction;Address;Administrator;Adoption;adverse outcome;arm;Attitude;Breast Feeding;Buprenorphine;Caring;Case Management;Child;Child Welfare;Cluster randomized trial;Contraceptive Agents;Contraceptive methods;cost;Counseling;design;Discipline of obstetrics;Education;effectiveness testing;Environment;Evidence based practice;Evidence based treatment;experience;Face;first responder;Goals;Gynecologist;HCV screening;Health;health care service;health care settings;Health Services Accessibility;Health Services Research;Health system;Healthcare;HIV/HCV;implementation science;improved;innovation;Intervention;Interview;Investments;Knowledge;Maternal and Child Health;Maternal Health;maternal morbidity;maternal opioid use;Medicaid eligibility;medication-assisted treatment;Methods;Modeling;mortality;Neonatal Abstinence Syndrome;neonatal health;neonatal morbidity;neonatal outcome;New York;opioid use disorder;Organizational Change;organizational readiness;Outcome;Patient Care;Patients;Pennsylvania;Play;Postpartum Period;Postpartum Women;Pregnancy;Pregnant Women;prenatal;Prevalence;prevent;Preventive healthcare;Provider;provider adoption;randomized, clinical trials;Recommendation;Research;Resource-limited setting;Resources;Role;Rural;rural area;Site;social stigma;substance abuse treatment;substance use;teleconsultation;telepsychiatry;Testing;Training;Training and Education;Training Programs;treatment as usual;treatment program;treatment services;United States;Woman;Work

PROJECT_TITLE: Project STEPuP: A prenatal provider education and training program to improve medication-assisted treatment use during pregnancy and maternal and child health outcomes

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Emergency Care;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: BRONX

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Severe inequities in HIV pre-exposure prophylaxis (PrEP) access and use in communities hardest hit by the HIV epidemic persist, further exacerbating ongoing racial/ethnic and socioeconomic disparities in HIV incidence. In these same communities, many patients at risk for HIV seek care for sexually transmitted infections (STIs) in Emergency Departments (EDs), but the structure of traditional ED care is poorly suited to address HIV prevention or provide PrEP. To advance the Prevent objective of the Ending the HIV Epidemic (EHE) initiative, ED2PrEP will leverage an implementation science approach to rigorously test two innovative strategies for increasing PrEP uptake among patients seeking STI care in EDs in one of the 48 EHE-identified geographic hotspots.

PI_NAMEs: FELSEN, URIEL  (contact);PATEL, VIRAJ V

PROGRAM_OFFICER_NAME: SHARMA, USHA K

PROJECT_TERMS: Acceleration;acceptability and feasibility;Accident and Emergency department;Acute;Address;Adoption;AIDS prevention;Behavioral;Black race;budget impact;care seeking;Caring;Clinic;Communities;cost;cost effectiveness;Counseling;County;Cross-Over Trials;Data;design;economic evaluation;Education;Effectiveness;effectiveness testing;effectiveness/implementation trial;Elements;Eligibility Determination;Emergency Care;Emergency Department patient;Emergency department visit;Epidemic;Equipoise;ethnic disparity;evidence base;Geography;Goals;Health;health equity promotion;Health Personnel;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;high risk;HIV;HIV diagnosis;HIV Infections;HIV risk;HIV Seropositivity;implementation determinants;implementation evaluation;implementation outcomes;implementation science;Incidence;Inequity;innovation;Knowledge;Latino;Latinx;Latinx population;Life;Maintenance;medical specialties;member;Modeling;Newly Diagnosed;Outcome;outreach;Patients;Persons;Population;Populations at Risk;pre-exposure prophylaxis;preservation;prevent;prevent epidemics;Prevention;preventive intervention;primary outcome;Proctor framework;Provider;racial disparity;Reach, Effectiveness, Adoption, Implementation, and Maintenance;relative cost;Research;Risk;Risk Factors;scale up;secondary outcome;Sexual Health;Sexually Transmitted Diseases;socioeconomic disparity;Structure;telehealth;Testing;Time;trial comparing;uptake;Viral;Visit

PROJECT_TITLE: ED2PrEP - patient focused, low-burden strategies for PrEP uptake among emergency departments patients: a cross-over hybrid implementation-effectiveness trial


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative Recent evidence shows that there is a bidirectional relationship between epilepsy and Alzheimer’s Disease (AD), with an increased incidence of epilepsy in AD and higher dementia risk in people with epilepsy. Seizures and network hyperexcitability may be a treatable component of AD, as our recent preclinical results show that seizures can accelerate AD pathology. We will use novel AD mouse models and human tissue studies to identify neurodegenerative mechanisms triggered by seizure activity, as well as test efficacy of targeted therapies.

PI_NAMEs: JENSEN, FRANCES E (contact);TALOS, DELIA

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Acceleration;Address;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;amyloid pathology;anti-epileptic agents;Anticonvulsants;Attenuated;Autopsy;behavior test;Behavioral;Blood specimen;Brain;brain control;Brain Mapping;Brain region;brain tissue;Cell Separation;Cells;Chronic;clinical biomarkers;comorbidity;comparison control;Complex;Dementia;dementia risk;Deposition;Disease;Disease Progression;Distant;efficacy testing;Elements;Epilepsy;Epitopes;Exhibits;Fluorescence Microscopy;FOS gene;FRAP1 gene;Gene Expression;Generations;high risk;Hippocampus;Human;human tissue;Hyperactivity;hyperphosphorylated tau;Immediate-Early Genes;Impaired cognition;Incidence;Induced Neurons;inhibitor;innovation;interest;Label;Late Effects;Levetiracetam;Light;Maps;Measures;Mediating;Metabolism;Methods;Modification;Molecular;mouse model;Mus;Nerve Degeneration;neuron loss;Neurons;neuropathology;neurotransmission;novel;novel therapeutic intervention;Outcome;Pathologic;Pathology;Pathway interactions;Patients;Pentylenetetrazole;Persons;Phosphoric Monoester Hydrolases;Phosphorylation;Play;Positron-Emission Tomography;pre-clinical;Process;protein expression;Proteins;Recording of previous events;Seizures;Senile Plaques;Severities;Signal Pathway;Signal Transduction;Sirolimus;spatiotemporal;Synapses;Synaptic Transmission;Synaptic Vesicles;Tamoxifen;targeted treatment;tau aggregation;tau expression;tau mutation;tau Proteins;tau-protein kinase;Tauopathies;Testing;Therapeutic Effect;Tissue-Specific Gene Expression;transcriptome;transcriptome sequencing;transmission process;Treatment Efficacy;uptake;vesicular release;Western Blotting

PROJECT_TITLE: Seizure-induced enhancement of synaptic signaling regulating tau transmissibility in Alzheimer's Disease


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Data Science;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative In the human body, for 100 human cells that are present, there are 130 microbial cells. Those microbes often define the balance of human health and disease, yet the molecules by which they promote this balance are unknown. We have designed a reverse metabolomics and big data mining strategy to discover microbial metabolites with emphasis on microbial metabolites associated with inflammatory bowel disease and other gut associated metabolic disorders.

PI_NAMEs: DORRESTEIN, PIETER C (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Acetic Acids;Acylation;Affect;Age;Amines;Animals;Award;Big Data;Biological;Biological Assay;Cells;Colitis;combinatorial;Communities;Coupling;cytokine;cytotoxicity;Data;data exchange;data library;data mining;data repository;Data Science;Data Scientist;Data Set;design;Development;Diet;Disease;Diversity Library;Epithelial Cells;Epithelium;Equilibrium;Equipment and supply inventories;Etiology;FAIR principles;Food;Foundations;Frequencies;Funding;Gene Cluster;glycosylation;Goals;Grant;Health;Human;Human body;human microbiota;Hydration status;Hydrolysis;in vivo;Inflammatory Bowel Diseases;Information Resources;instrument;Joints;Knowledge;knowledge base;knowledgebase;Libraries;Lithocholic Acid;Liver diseases;Macrophage;Mass Spectrum Analysis;meetings;Metabolic;Metabolic Biotransformation;Metabolic Diseases;metabolomics;Methylation;Microbe;microbial;microbiome;microbiota;Mining;Modeling;Molecular Structure;Monitor;murine colitis;novel;Nutritional;Obesity;Organ;Organic Synthesis;oxidation;Oxides;Paper;Pharmaceutical Preparations;Phenotype;Phosphorylation;Play;precision medicine;prevent;Process;Production;Propionic Acids;Publications;Reaction;Research;Role;sex;signature molecule;small molecule;Sodium Dextran Sulfate;Source;Structure;Sulfate;T cell response;T-Lymphocyte;Tissues;tool;Xenobiotics

PROJECT_TITLE: Reverse Metabolomics for the Discovery of Disease Associated Microbial Molecules

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Opioids;Prescription Drug Misuse;Stem Cell Research;Stem Cell Research - Embryonic - Human;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE HIV-associated neurocognitive disorder (HAND) is a major health problem affecting the quality of life for millions of HIV+ patients. Our proposed research will use innovative human stem cell technologies to investigate the mechanisms of how HIV infection leads to HAND by altering the function of microglia, the primary immune cells within the brain. Through these studies, we will gain a deeper understanding of the root causes of HAND and potentially identify new therapeutic targets.

PI_NAMEs: FREGOSO, OLIVER I;NOVITCH, BENNETT G (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: 3-Dimensional;Acquired Immunodeficiency Syndrome;Acute;acute infection;Affect;AIDS dementia;antiretroviral therapy;Astrocytes;Autopsy;Biological Assay;Biology;Brain;Cell Culture System;Cells;Cessation of life;Chronic;chronic infection;Consequences of HIV;cytokine;Development;Dimensions;Disease;Drug usage;Epidemic;experience;Face;Foundations;Functional Imaging;Gene Expression;Genetic Transcription;Health;Heroin;Histopathology;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;Human;human pluripotent stem cell;human stem cells;human tissue;Immune;immune activation;Immune response;Immune signaling;in vitro Model;Individual;Infection;Inflammation;Innate Immune Response;innovation;insight;Intravenous;Knowledge;Measures;method development;Microglia;Modeling;Molecular;Monitor;monocyte;Myeloid Cells;Nerve Degeneration;Nervous System Disorder;neural;neural network;Neural Network Simulation;Neurocognitive;Neurocognitive Deficit;neurocognitive disorder;neuroinflammation;Neurons;neuropathology;Neurophysiology - biologic function;Neuroprotective Agents;new therapeutic target;Opioid;Organoids;Pathology;Patients;Persons;Pharmaceutical Preparations;Play;Population;Preclinical Testing;prescription opioid abuse;Productivity;Quality of life;Research;response;Role;Signal Transduction;single nucleus RNA-sequencing;stem cell technology;Structure;success;Synapses;System;Systems Analysis;Testing;Therapeutic;Tissues;Translating;Unmarried person;Viral Load result

PROJECT_TITLE: Integrative Modeling of HIV-Associated Neurocognitive Disorder in Human Brain Organoids


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Patient Safety

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE There is an increasing need for the development of new and effective drug therapies for the treatment of disease that can be tailored for individual patients. Students in the Pharmaceutical Sciences and Pharmacogenomics Graduate Program are trained to be future scientific leaders in this area. Their training will prepare them to develop effective treatment strategies for existing and newly developed drugs that consider the principles of pharmacology and our advancing knowledge of personal genetics.

PI_NAMEs: GUO, SU  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: AMES

ORG_DEPT: CHEMISTRY

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE The proposed research will reveal regulatory mechanisms in high molecular weight enzymes that are essential for human and bacterial metabolism. Our study will indicate novel strategies guided by atomic resolution insight in enzyme conformational changes to selectively target these proteins with small molecules that inhibit bacterial infections and cancer progression.

PI_NAMEs: VENDITTI, VINCENZO  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Active Sites;Affect;Antibiotics;Bacterial Infections;bacterial metabolism;Binding;biochemical tools;Biological Process;biophysical tools;cofactor;Communication;Complex;Coupling;Dioxygenases;Disease;enzyme structure;Enzymes;Family;flexibility;frontier;Future;Goals;Human;inhibitor;insight;Investigation;Malignant Neoplasms;Mediating;Metabolism;Molecular Conformation;Molecular Weight;Motion;Multienzyme Complexes;nanomachine;novel;novel strategies;Nucleic Acids;obesity treatment;Phosphotransferases;Play;programs;Proteins;Regulation;Research;Residual state;Resolution;Series;small molecule;Source;System;tool;tumor progression;Visualization

PROJECT_TITLE: Atomic-level characterization of self-regulatory mechanisms in large multidomain enzymes

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: NEW ORLEANS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Vaccines are one of the most important medical interventions in history, yet every year nearly 15 million people die worldwide from infectious diseases. The majority of infections are caused by bacterial or viral pathogens that enter and colonize the mucosa, such as the lung or gastrointestinal and reproductive tracts. The goal of the proposed research is to understand how adjuvant combinations can be used to direct immunity to the mucosal tissues and how these responses can be enhanced or “tuned” to target particular pathogens. As such, the pro- posed research is relevant to the part of the NIH’s mission that pertains to developing fundamental knowledge to reduce the burdens of human disease.

PI_NAMEs: MCLACHLAN, JAMES B (contact);MORICI, LISA A

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Address;Adjuvant;ADP ribosylation;Affect;aluminum sulfate;Antibodies;Antibody Formation;Antibody-mediated protection;Antigens;B-Lymphocytes;Bacterial Infections;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Communication;Cell Count;cell motility;Cells;Cellular Immunity;Chlamydia;Citrobacter;combat;Communicable Diseases;Data;draining lymph node;Drug Metabolic Detoxication;Enterotoxins;Escherichia coli heat-labile toxin;experimental study;female reproductive tract;Future;Gastrointestinal tract structure;Goals;human disease;Humoral Immunities;Immune;Immune response;Immunity;Immunization;Immunoglobulin Class Switching;Individual;Infection;Influenza;Injections;innovation;insight;Intervention;Intestinal Mucosa;Intramuscular;Investigation;Knowledge;Licensing;Lung;Lymphoid Tissue;Major Histocompatibility Complex;Medical;Membrane;Memory;Memory B-Lymphocyte;migration;Mission;Modeling;Mucosal Immune Responses;Mucosal Immunity;mucosal site;Mucous Membrane;Mus;mutant;novel;Outcome;Parabiosis;parenteral administration;pathogen;pathogenic bacteria;pathogenic virus;Persons;Phenotype;Play;Program Development;protective efficacy;Publishing;Recording of previous events;reproductive tract;Research;response;Role;Site;Structure of parenchyma of lung;Surface;T-Cell Activation;T-Lymphocyte;Testing;tissue resident memory T cell;Tissues;tool;trafficking;United States National Institutes of Health;Vaccination;Vaccine Adjuvant;Vaccine Antigen;Vaccine Design;vaccine development;Vaccines;Vesicle;Virus Diseases;Work

PROJECT_TITLE: Using parenteral combination adjuvants to induce pan-mucosal cellular and humoral immunity

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Mental Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PITTSBURGH

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Traumatic brain injuries (TBIs) affect 2.8 million individuals each year in the United States and often cause long-lasting cognitive and mood alterations, with the greatest external cause for TBI being falls, especially in older adults over 65 years of age. Given that behavioral tests performed to date after experimental brain trauma have primarily focused on motor and spatial learning deficits and not on commonly-reported complex attention impairments, this R01 application aims to characterize alterations in sustained attention, behavioral flexibility, and anxiety-like responses after experimental TBI in both young adult and aged rats, as well as to address mechanistic questions regarding altered cholinergic neurotransmission responsible for such behavioral impairments by restoring behavioral performance and acetylcholine brain marker levels with NS 1738 - a positive allosteric modulator of alpha-7-nicotinic acetylcholine receptors – alone or in a combination with enriched environment housing as a preclinical model of neurorehabilitation. Integrating animal models of higher-order cognitive processing in the behavioral battery after TBI is paramount to finding clinically-relevant therapeutic targets, and therefore the proposed studies will be carried out in males and females, an approach which may prove valuable for translation from bench to bedside and advanced rehabilitation research.

PI_NAMEs: BONDI, CORINA OANA (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Abbreviations;Acetylcholine;Acetylcholinesterase;Address;Affect;affective disturbance;age related;Age Years;aged;Aging;aging process;aging related;Agonist;alpha-bungarotoxin receptor;Alzheimer's disease related dementia;Alzheimer's disease risk;Animal Model;Anti-Inflammatory Agents;Anxiety;arm;Attention;Behavior;behavior test;Behavioral;behavioral impairment;behavioral outcome;bench-to-bedside translation;Biological Markers;Brain;Brain region;Choline O-Acetyltransferase;cholinergic;Chronic;Clinic;clinically relevant;Cognition;Cognitive;cognitive process;Combined Modality Therapy;Complex;controlled cortical impact;Corpus striatum structure;Cytoskeleton;desensitization;design;Dimensions;Dorsal;environmental enrichment for laboratory animals;executive function;Exhibits;Exposure to;falls;Female;flexibility;frontotemporal degeneration;Functional disorder;Glial Fibrillary Acidic Protein;Goals;Growth;Hippocampus;Housing;human old age (65+);Impaired cognition;Impairment;Impulsivity;Individual;Injury;Ipsilateral;Laboratories;Learning;male;Mass Spectrum Analysis;Measures;Mediating;Memory;Menstrual cycle;Mental Depression;methyllycaconitine;Modeling;Motivation;Motor;neurobehavior;neurobehavioral;Neurobiology;neurogenesis;neurological rehabilitation;Neuron-Specific Enolase;Neurons;neuroprotection;neurotransmission;Neurotransmitters;Nicotinic Receptors;novel;older adult;Parietal;Pathway interactions;Performance;Pharmaceutical Preparations;Pharmacotherapy;Play;positive allosteric modulator;pre-clinical;Pre-Clinical Model;predictive marker;Predisposition;premature;Proteins;Proteomics;Psychopathology;Rattus;Reaction Time;receptor;Regulation;rehabilitation research;Rehabilitation therapy;Reporting;Research Personnel;response;Rewards;Risk;Role;self-reported anxiety;Serum;Short-Term Memory;Signal Transduction;Survivors;sustained attention;Synaptic plasticity;System;TBI treatment;Testing;Therapeutic;therapeutic target;Tissues;tool;Translating;transmission process;Traumatic Brain Injury;United States;Western Blotting;Woman;young adult

PROJECT_TITLE: Traumatic brain injury and aging: targeting the cholinergic system for deficits in sustained attention and executive function

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Microbiome;Nutrition

ORG_CITY: RALEIGH

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: Project Narrative The proposed research is relevant to public health because understanding how interactions between dietary protein and the intestinal microbiota impact human health will allow rational design of customized therapeutic interventions that consider detrimental and beneficial impacts of different dietary protein sources. Thus, the proposed research is relevant to the part of the NIH's mission that pertains to developing fundamental knowledge that will reduce the burdens of human illness. The research is also relevant to the mission of the NIGMS as it will provide new, broadly applicable methods to increase the understanding of functional interactions between humans and their microbiota, which lays the foundation for advances in disease diagnosis, treatment and prevention.

PI_NAMEs: KLEINER, MANUEL  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Biochemical;Biological Assay;cellular imaging;Communities;Consumption;Development;Diet;Dietary Proteins;Disease;disease diagnosis;Environment;Foundations;Gene Expression;Goals;gut microbiota;Health;host microbiota;host-associated microbial communities;Human;Human Microbiome;human microbiota;In Vitro;insight;Intestines;Knowledge;Laboratory Study;Mass Spectrum Analysis;Measurement;member;metabolic abnormality assessment;metabolomics;Metagenomics;metaproteomics;Methods;microbial;microbial community;microbiota;Mission;National Institute of General Medical Sciences;novel strategies;Physiology;Prevention;Proteins;Public Health;rational design;Reproducibility;Research;Resolution;response;Site;Source;Symbiosis;therapeutic development;Therapeutic Intervention;tool;United States National Institutes of Health

PROJECT_TITLE: Metaproteomics to investigate intestinal microbiota-host and -diet interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Data Science;Genetics;Human Genome;Obesity;Precision Medicine;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Individuals who develop cardiometabolic diseases may not have elevations in risk factors suggesting that there are other risk mediators underlying diseases that are not yet identified. This project will use cutting-edge and innovative multi-omics approaches which examine many factors measured in blood to identify groups of individuals who are biologically similar and will determine whether the groups have different functional and/or pathophysiological risk mechanisms for disease or different response to treatments. These groups can be further studied to determine their risk mechanisms, and this will ultimately lead to new personalized ways of managing and preventing cardiometabolic diseases.

PI_NAMEs: BAGHERI NARAGHI, MINOO SADAT  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Address;Adult;bariatric surgery;Big Data;biobank;Bioinformatics;Biological;Biological Markers;Biology;Blood;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Clinical;clinical diagnosis;clinically relevant;Consensus;Coronary Arteriosclerosis;Data;Data Set;Development;Diabetes Mellitus;Disease;Disease Clusterings;Disease Progression;Disease susceptibility;disorder risk;disorder subtype;DNA;Electronic Health Record;experience;Framingham Heart Study;Gene Expression;genome wide association study;Genotype;Goals;high dimensionality;high risk;Hypertension;improved;Individual;innovation;Jackson Heart Study;Knowledge;Link;Measurement;Measures;Mediating;Mediator;Metabolic syndrome;Metabolism;metabolome;metabolomics;Methods;Morbidity - disease rate;mortality;Multi-Ethnic Study of Atherosclerosis;Multiomic Data;multiple omics;National Heart, Lung, and Blood Institute;network models;novel;obese patients;Obesity;Onset of illness;Participant;Pathway Analysis;Patients;personalized diagnostics;phenome;Phenotype;phenotypic data;Plasma;polygenic risk score;predicting response;prevent;programs;Prospective cohort;Proteome;Proteomics;Public Health;Research;Resources;Risk;Risk Factors;risk stratification;Scientist;skills;small molecule;study population;Subgroup;targeted treatment;Testing;Therapeutic;Time;tool;Training;training opportunity;Trans-Omics for Precision Medicine;transcriptome;transcriptomics;treatment response;treatment strategy

PROJECT_TITLE: Leveraging multi-omics for endotyping to identify subtypes and mechanisms of cardiometabolic diseases

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: NEUROSURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Reprogramming of predominant immune suppressive innate immunity may allow for immunological clearance of glioblastoma. In a Phase II clinical trial, a blood brain barrier penetrant modulator of a key hub of gliomagenesis and immune suppression, the signal transducer and activator of transcription 3, is combined with standard of care radiation to trigger immune activation within the tumor microenvironment.

PI_NAMEs: HEIMBERGER, AMY BETH (contact);KUMTHEKAR, PRIYA U.

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: adaptive immunity;Animal Model;Animals;Antigen Presentation;Antigen-Presenting Cells;Antitumor Response;Blood - brain barrier anatomy;Brain;Brain Neoplasms;Brain Stem Glioma;cancer cell;CD11c Antigens;CD3 Antigens;Cell Physiology;Cells;Cellular immunotherapy;Childhood;Clinical;Clinical Trials;cohort;Combined Modality Therapy;Dendritic cell activation;Dendritic Cells;Dependence;Dose;Drug Kinetics;Education;Effectiveness;Excision;first-in-human;Flow Cytometry;Glioblastoma;Gliomagenesis;Goals;Heterogeneity;High Pressure Liquid Chromatography;Human;Immune;immune activation;immune clearance;Immune response;Immune system;Immunocompromised Host;immunogenicity;Immunohistochemistry;Immunologics;Immunosuppression;Immunotherapy;improved;Infiltration;Inflammatory Response;Lesion;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;Memory;Metastatic malignant neoplasm to brain;MGMT gene;Microglia;Modeling;Mus;Myeloid Cells;nano-string;Natural Immunity;neuro-oncology;Newly Diagnosed;Operative Surgical Procedures;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacodynamic biomarker;pharmacologic;phase 3 study;Phase I Clinical Trials;phase I trial;Phase II Clinical Trials;phase II trial;Phenotype;Population;pre-clinical;preclinical study;Progression-Free Survivals;Radiation;Radiation therapy;radiological imaging;Recurrence;Research;response;Signal Induction;small molecule inhibitor;standard of care;Stat3 protein;T cell infiltration;T-Cell Activation;T-Lymphocyte;Testing;Texture;Tissues;tumor;tumor microenvironment;tumor-immune system interactions;Universities;Validation

PROJECT_TITLE: A Phase II Clinical Trial in Newly Diagnosed Glioblastoma Patients Treated with WP1066 and Radiation

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: The mission of the Molecular and Cellular Biology program is to train interdisciplinary PhD students who rigorously apply the conceptual and experimental tools of molecular and cellular biology. This new incarnation of a long-standing integrative training program will emphasize quantitative instruction together with activities that promote excellence in communication, mentorship, collaboration, and social/cultural awareness. Graduates will be prepared for a variety of academic or research-related careers.

PI_NAMEs: ARAC-OZKAN, DEMET ;GLICK, BENJAMIN S;MUNRO, EDWIN MARSHALL (contact);RICE, PHOEBE A

PROJECT_TERMS: Molecular and Cellular Biology;Training Programs

PROJECT_TITLE: Molecular and Cellular Biology Training Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Estrogen;Mental Health;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The specific cell types that make up neural circuits, the ensembles of cells in our brain that coordinate behavior in health, are poorly understood. Our basic research project focuses on characterizing a specific cell type located in a brain center critical for social interactions. Our study will shed light on how this cell type normally regulates social behaviors and may have implications for how disease states alter such neural circuits and disrupt emotional well-being and social interactions in neurological and psychiatric disorders.

PI_NAMEs: SHAH, NIRAO MAHESH (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Aggressive behavior;Anatomy;Basic Science;Behavior;Behavioral;Biological Assay;Brain;Brain region;calcium indicator;Cell Nucleus;cell type;Cells;Complex;conditional knockout;deep sequencing;Diagnostic;Disease;Emotional;Engineering;ESR1 gene;experimental study;Female;Fiber;Fluorescence;frontal lobe;Funding;Gene Expression;genetic approach;Goals;Gonadal Steroid Hormones;Halorhodopsins;Health;Hormone Receptor;Human;Image;improved;Individual;insight;Knowledge;Link;male;Mammals;Mental disorders;Molecular;Motor output;Mouse Strains;Mus;Nervous System Disorder;neural circuit;Neural Pathways;Neurologic;Neurons;Neuropeptides;neuropsychiatry;Neurosciences;Opsin;optogenetics;Output;Partner in relationship;Pathway interactions;Photometry;Population;Reproductive Health;reproductive success;Research Project Grants;Role;sensor;sensory input;sex;sexual dimorphism;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Social Behavior;social influence;Social Interaction;Specific qualifier value;Structure of terminal stria nuclei of preoptic region;Substance P;Synapses;Tachykinin;TACR1 gene;targeted treatment;Technology;Testing;transcriptomics;Viral;Visualization;Well in self;Work

PROJECT_TITLE: Characterization of sexual dimorphism in the brain

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE This randomized trial will rigorously measure whether installing concrete floors in homes with soil floors reduces household fecal contamination, child soil-transmitted helminth infection, and child diarrhea in a low- resource, rural setting. Our findings will provide rigorous, policy-relevant evidence about whether concrete flooring installation should be delivered as a public health intervention to improve child health.

PI_NAMEs: BENJAMIN-CHUNG, JADE  (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: 5 year old;Age;age group;aged;Anemia;Ascaris;Ascaris lumbricoides;Bangladesh;Bangladeshi;behavior change;Birth;Cause of Death;Child;Child Development;Child Health;chlorination;cohort;Colony-forming units;Cost Effectiveness Analysis;cost-effectiveness ratio;Diarrhea;disability-adjusted life years;Eating;egg;Eligibility Determination;enteric infection;enteric pathogen;Escherichia coli;experience;Exposure to;Feces;Floor;follow-up;Food;Frequencies;Geography;Growth;Hand;Handwashing;Health;Health Benefit;Health Promotion;helminth infection;Helminths;Home;Home environment;Hour;Household;Housing;Hygiene;Impairment;improved;in utero;incremental cost-effectiveness;Infectious Disease Epidemiology;Ingestion;innovation;Interruption;Intervention;Intervention Trial;Latrine;Life;Low Prevalence;lower income families;Maintenance;maternal depression;maternal outcome;maternal stress;Measurement;Measures;Mental Depression;Morbidity - disease rate;mortality;Necator americanus;Observational Study;Oral cavity;Outcome;Outcome Measure;Participant;Pathway interactions;Play;Policies;Pregnant Women;Prevalence;prevent;primary endpoint;Public Health;public health intervention;Quality of life;Randomized;randomized trial;Recording of previous events;Research;Resource-limited setting;Resources;Risk;Rural;rural setting;Sampling;Sanitation;scale up;Scientist;Second Pregnancy Trimester;secondary endpoint;Sentinel;Soil;Stress;Structure;Swab;Taxes;Testing;therapy design;Thinking;Third Pregnancy Trimester;Time;Toy;transmission process;Trichocephalus trichiura;Water

PROJECT_TITLE: Effects of household concrete floors on child health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(90)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PHR: This program enhances clinical and translational research by providing interdisciplinary training and mentorship to early-career investigators. The resulting improvements in research productivity and collaboration will accelerate scientific contributions to human health.

PI_NAMEs: DEPP, COLIN A. (contact)

PROGRAM_OFFICER_NAME: ATIENZA, AUDIE A

PROJECT_TERMS: access disparities;Acute;Address;Applied Research;Area;biobank;Bioinformatics;Biomedical Research;Blood Banks;California;career;career development;Clinical;Clinical Research;Collaborations;commercialization;community building;community engagement;Community Health Networks;community partners;Computational Science;County;Coupled;Data;data dashboard;Development Plans;drug development;drug discovery;early-career faculty;Education;Educational Curriculum;Educational workshop;Engineering;Ensure;Entrepreneurship;Evaluation;evidence base;experience;externship;Faculty;faculty mentor;Foundations;Future;Goals;Grant;hands-on learning;Health;Health Sciences;Heterogeneity;Hispanic;Hospitals;Human;Immunology;implementation science;improved;Individual;Informatics;informatics tool;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;Master of Science;Medical center;Medicine;member;Mentors;Mentorship;Methodology;Methods;next generation;Outcome;outreach;Pediatric Hospitals;Pharmacy facility;Productivity;Program Development;programs;Public Health;Public Health Schools;Publishing;Research;Research Institute;Research Personnel;Resources;sabbatical;School Nursing;Schools;Science;science teacher;Scientist;Series;Services;skills;success;System;Techniques;tool;Training;training opportunity;Training Programs;Translational Research;trend;Underrepresented Minority;Universities;Writing

PROJECT_TITLE: Mentored Career Development Program


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Biomedical Imaging;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Osteoarthritis;Pain Research

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Many adults in the United States have knee osteoarthritis, which is a disabling disorder with no treatments to slow, stop, or reverse joint damage. A challenge to testing new treatments is the lack of a clear definition of disease progression and not knowing how much change in a structural measure would reflect a meaningful improvement or worsening to patients. Our goal is to determine how much change in two novel measures of disease progression translates to clinically meaningful improvement or worsening and receiving a knee replacement.

PI_NAMEs: DRIBAN, JEFFREY B (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Address;Adult;articular cartilage;Articulation;barrier to testing;Biological Factors;Biological Markers;biomarker validation;Body mass index;Bone Marrow;Cartilage;case control;Clinical;Clinical Trials;Collaborations;Data;Databases;Degenerative polyarthritis;design;disability;Disabling;Disease;Disease Progression;Drug Evaluation;early phase trial;effective therapy;effusion;end stage disease;Enrollment;Feedback;Funding;Goals;Image;imaging biomarker;improved;informant;Intervention;joint injury;Joints;Knee;Knee Osteoarthritis;knee replacement arthroplasty;Lesion;Letters;Logistic Models;Magnetic Resonance;Magnetic Resonance Imaging;Measures;Methods;Modeling;Modification;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;novel therapeutics;Outcome;Pain;pain reduction;Participant;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Performance;Persons;phase III trial;Population;predictive marker;Process;Prognostic Marker;programs;Qualifying;radiological imaging;Replacement Arthroplasty;repository;Research;Research Project Grants;Resources;ROC Curve;Sampling;Sampling Studies;Severities;sex;Standardization;Strategic Planning;success;Symptoms;Synovitis;Technology;Teleconferences;Testing;Therapeutic;Time;Translating;Uncertainty;United States;United States Food and Drug Administration;Visit;walking speed;Work

PROJECT_TITLE: Interpretation and Utility of Novel Composite Structural Endpoints of Cumulative Damage and Disease Activity in Knee Osteoarthritis

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: OVERALL NARRATIVE – MATERNAL DETERMINANTS OF INFANT IMMUNITY (MADI) Building on the premise that the maternal and infant immune states, from gestation and through the first months of life, are interconnected entities, we propose a research program aimed at transforming our understanding of the determinants of immunity against infectious agents early in life. Through coordinated, synergistic, and multidisciplinary studies, and utilizing advanced technologies and approaches, MADI will generate essential knowledge to inform the development of new and improved interventions to enhance maternal and infant health.

PI_NAMEs: PASETTI, MARCELA F (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: 5 year old;Address;Adult;Affect;analytical tool;Animal Model;Antibodies;antibody engineering;antibody transfer;Antibody-mediated protection;Biophysics;Cause of Death;Cells;Child;Childhood;Clinical;cohort;Communicable Diseases;Complex;complex data;Data Analyses;data dissemination;data management;Data Science;Data Set;Development;Effectiveness;Environment;fitness;Goals;Health;Human Milk;human tissue;Immune;Immune system;Immunity;Immunization;Immunobiology;Immunologics;Immunology;Immunotherapy;improved;In Vitro;Infant;Infant Health;Infection;infection burden;Infectious Agent;Infectious Disease Immunology;Influenza;insight;interest;Intervention;Intrinsic factor;Knowledge;Learning;Life;Link;Logistics;longitudinal analysis;low and middle-income countries;Maternal and Child Health;Maternal antibody;Maternal Health;maternal vaccination;Maternally-Acquired Immunity;Mediating;Methods;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mothers;multidisciplinary;multimodality;neonatal immunity;Newborn Infant;novel;pathogen;Pathway interactions;Pertussis;Placenta;predicting response;Predisposition;Pregnancy;Pregnant Women;prevent;Productivity;programs;Public Health;Quality Control;Recommendation;Research;Research Personnel;response;Role;Series;Serology;Specimen;Structure;success;System;T cell response;Technology;Tetanus;Time;Tissue Model;Training;translational research program;Vaccination;Vaccine Design;vaccine immunogenicity;vaccine response;vaccine-induced antibodies;vaccine-induced immunity;Vaccines;vaccinology

PROJECT_TITLE: Maternal Immunization and Determinants of Infant Immunity


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: Narrative Malfunction of the midbrain dopamine system is associated with a variety of pathological conditions including depression, anhedonia, apathy, schizophrenia, addiction, eating disorders and Parkinson’s disease. In particular, aberrant dopamine responses to salient events have been implicated in addiction, schizophrenia and other mental disorders. Understanding dopamine signaling in the healthy brain is essential to understanding states of aberrant dopamine signaling.

PI_NAMEs: DRUGOWITSCH, JAN ;UCHIDA, NAOSHIGE  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: addiction;Algorithms;Anhedonia;Animals;Artificial Intelligence;artificial neural network;Association Learning;Back;Brain;Characteristics;Code;Data Analyses;deep learning;Development;Dopamine;dopamine system;dopaminergic neuron;Eating Disorders;Environment;Event;expectation;Experimental Designs;Feedback;Future;Goals;improved;in silico;Investigation;Learning;learning algorithm;Mental Depression;Mental disorders;Midbrain structure;Modeling;Modification;Monitor;Mus;network architecture;Neurobiology;neuromechanism;Neurons;optimism;optogenetics;Parkinson Disease;Pathologic;Population;Predictive Value;Probability;Psychological reinforcement;response;Rewards;Scheme;Schizophrenia;Signal Transduction;simulation;Stimulus;Structure;Testing;theories;Ventral Striatum;Ventral Tegmental Area;Work

PROJECT_TITLE: Distributional Reinforcement Learning in the Brain


PROJECT_TERMS: Accountability;Achievement;Achyrocline;Address;Agreement;Annual Reports;Baltimore;Biostatistics Core;Collaborations;Communication;Communications Media;Communities;Computer software;data management;Ensure;flexibility;Fostering;Funding;global health;Goals;Immunity;Infant;Infrastructure;Institution;Intellectual Property;Lead;Leadership;Logistics;Maryland;material transfer agreement;maternal vaccination;medical schools;meetings;Monitor;Office of Administrative Management;operation;Principal Investigator;Productivity;Program Research Project Grants;programs;Progress Reports;Quality Control;Records;Regulation;Reporting;repository;Research;Research Personnel;Resource Allocation;Resources;Role;Services;Site;synergism;timeline;tool;United States National Institutes of Health;Universities;vaccine development;web site;Work


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: In this proposal, we use a novel comparative approach to define how variation in Drosophila brain circuits gives rise to species-specific behavioral variation. As the etiology of many brain disorders is aberrant neural circuit wiring, a deeper understanding of the link between genes, neural circuits, and behavior could have profound consequences for neurological health.

PI_NAMEs: RUTA, VANESSA  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Anatomy;Animals;Behavior;Behavioral;Brain;Brain Diseases;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;Courtship;Drosophila genus;Etiology;Evolution;Exhibits;Gene Expression Profiling;Genes;Genetic;genome editing;Health;innovation;Light;Link;Maps;Mental Health;Molecular;Nervous System;neural;neural circuit;neurogenetics;Neurologic;novel;Partner in relationship;Pathway interactions;Population;preference;Resolution;Sensory;Technology;tool;Translating;Variant

PROJECT_TITLE: Using evolutionary variation to probe the neural basis for behavior


NIH_SPENDING_CATS: Biotechnology;Immunization;Maternal Health;Pediatric;Prevention;Vaccine Related;Women's Health Research

PI_NAMEs: ALTER, GALIT  (contact)

PROJECT_TITLE: Systems Serology Core


NIH_SPENDING_CATS: Childhood Injury;Clinical Research;Kidney Disease;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Acute kidney injury in children with chronic kidney disease is associated with an increased risk of death and is thought to be a risk factor for an accelerated loss of kidney function. We will conduct research on children with chronic kidney disease to determine risk factors for acute kidney injury, assess glomerular and tubular health after acute kidney injury, and identify children at high risk of rapid kidney function decline after acute kidney injury. These studies may allow for the early detection and prompt treatment of rapid kidney function decline, inform clinical trial enrollment, and provide the foundation for interventional studies to improve long-term health in children with chronic kidney disease.

PI_NAMEs: GREENBERG, JASON HENRY (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Acceleration;Acute Renal Failure with Renal Papillary Necrosis;Address;Adult;Albumins;Albuminuria;alpha-1-microglobulin;Biological;Biological Markers;Blood Pressure;CCL2 gene;Characteristics;Child;Childhood;Childhood Injury;Chronic Kidney Failure;Clinical;Clinical Data;clinical decision-making;Clinical Research;clinical trial enrollment;Clinical Trials;cohort;Cohort Studies;comorbidity;Creatinine;Data;Death Rate;Disease Progression;Early Diagnosis;Electronic Health Record;End stage renal failure;epidemiology study;Epidermal Growth Factor;Etiology;Event;Fibrosis;follow-up;Foundations;Functional disorder;Future;Growth;Health;Height;high risk;improved;Incidence;Inflammation;Injury;insight;Intervention;Intervention Studies;Kidney;Life;Link;Measurement;Measures;Modeling;modifiable risk;Molecular;mortality risk;Natural regeneration;nephrogenesis;Outcome;Participant;Pathogenesis;Pathway interactions;Pediatric Research;Persons;post gamma-globulins;preclinical study;prevent;progression risk;Prospective cohort;Proteinuria;Public Health;Quality of life;rat KIM-1 protein;Recording of previous events;renal damage;Renal function;Renal tubule structure;Research;research study;Risk;Risk Factors;risk prediction model;Role;Serum;Severities;Site;therapeutic target;Tubular formation;Urine;Visit;years of life lost

PROJECT_TITLE: Acute Kidney Injury in Children with Chronic Kidney Disease

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


NIH_SPENDING_CATS: Kidney Disease;Nutrition

ORG_CITY: VALHALLA

ORG_NAME: NEW YORK MEDICAL COLLEGE

PHR: NARRATIVE: Abnormal potassium and sodium transport occur commonly in the setting of chronic kidney disease and heart failure. We have now identified a novel mechanism by which the kidney can sense the change in dietary K+ and Na+ content and regulate K+ and Na+ excretion or absorption. The new concept will expend the current knowledge regarding renal K+ and Na+ transport and may lead to development of new approach for treatment of hypertension and dyskalamia.

PI_NAMEs: ELLISON, DAVID H;WANG, WENHUI  (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: absorption;Acute;Alanine;Angiotensin II;Angiotensin Type 1a Receptor;Apical;Chronic;Chronic Kidney Failure;Data;Development;dietary;Dietary intake;Dietary Potassium;Distal;Distal convoluted renal tubule structure;Dose;Electrolytes;epithelial Na+ channel;Excretory function;Heart failure;Homeostasis;hypertension treatment;Impairment;Infusion procedures;Intake;KCNJ1 gene;Kidney;Knockout Mice;Knowledge;Lysine;Mediating;Molecular;Mus;Nephrons;novel;novel therapeutic intervention;Pathway interactions;Pattern;Perfusion;Phosphotransferases;Physiological;Play;Potassium;Proline;Regulation;Renal tubule structure;response;Role;sensor;Signal Transduction;SLC12A3 gene;Sodium;symporter;Testing;Vasopressins

PROJECT_TITLE: Role of Kir4.1 in regulating NCC and ROMK in DCT

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Immunization;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Vaccine Related

PI_NAMEs: HOEN, ANNE GATEWOOD (contact)

PROJECT_TERMS: analysis pipeline;Archives;Award;Bioinformatics;bioinformatics pipeline;Biometry;Biostatistical Methods;Biostatistics Core;central database;Clinical;Code;Collaborations;Communities;Computer software;Consultations;Custom;Data;data access;Data Analyses;Data Analytics;Data Collection;data dissemination;data exploration;data handling;data integration;data management;data repository;data resource;Data Set;data sharing;data sharing networks;Data Storage and Retrieval;database query;Databases;design;Ensure;experience;Future;Goals;high dimensionality;Human Resources;human subject;Immune;Immunity;Individual;Infant;innovation;Laboratories;maternal vaccination;Mothers;multidimensional data;multidisciplinary;news;novel;Online Systems;Pattern;Phase;Procedures;programs;Protocols documentation;Publications;Quality Control;repository;Reproducibility;Research;Research Personnel;Resources;Role;Secure;Security;Services;Site;Standardization;statistical and machine learning;Study Subject;synergism;Terminology;Time;tool;web site;Work

PROJECT_TITLE: Data Management and Biostatistics


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Substance Misuse

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Recent animal studies have provided new evidence that the cerebellum may have a stronger link to the reward system of the brain than was previously recognized, raising the possibility that cerebellar dysfunction could contribute substantially to addiction via a cerebellar influence over reward centers. We will investigate the nature of the cerebellar contribution to reward processing, how this contribution is altered by alcohol use disorder, and the extent to which cerebellar/brainstem dysfunction is related to over-activation of reward centers in individuals with alcohol use disorder. We will further investigate if reducing cerebellar activation to alcohol-related stimuli with cerebellar stimulation will reduce activation in reward centers, and reduce craving for alcohol.

PI_NAMEs: DESMOND, JOHN E (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: addiction;alcohol craving;alcohol cue;alcohol effect;alcohol response;alcohol use disorder;Alcoholism;Alcohols;Animals;Anodes;Association Learning;Behavioral;Blinking;Brain;Brain region;Brain Stem;Cell Nucleus;Cerebellar Cortex;Cerebellar Diseases;Cerebellum;comparison control;conditioned place preference;conditioning;Corpus striatum structure;Coupling;craving;cue reactivity;Cues;Data;Disinhibition;drinking;Event;expectation;eyeblink conditioning;financial incentive;Functional disorder;Functional Magnetic Resonance Imaging;hemodynamics;Human;Individual;Intervention;Investigation;Link;Measures;motor control;Motor Cortex;Nature;Neuroanatomy;Neurons;neuroregulation;neurotransmission;Nucleus Accumbens;Outcome;Output;Participant;Pathway interactions;Patients;Performance;Prosencephalon;Psychophysiology;Relapse;response;Rest;reward processing;Rewards;Signal Transduction;Source;Stimulus;Structure;System;Therapeutic;transcranial direct current stimulation;Ventral Tegmental Area

PROJECT_TITLE: Investigation of cerebellar involvement in AUD

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Breastfeeding, Lactation and Breast Milk;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Maternal Health;Pediatric;Pneumonia and Influenza;Pregnancy;Prevention;Vaccine Related;Women's Health Research

PROJECT_TERMS: Activities of Daily Living;Adoptive Transfer;Adult;Affect;Antibodies;Antibody Response;antibody transfer;Antigens;antimicrobial;Avidity;B-Lymphocytes;Binding;Biological Assay;Biological Process;biophysical properties;Biophysics;Bordetella pertussis;Cell Compartmentation;Child;Circulation;Clinical;cohort;Cohort Analysis;Data;design;Development;Dimensions;Diphtheria;Diphtheria-Tetanus-acellular Pertussis Vaccines;effective intervention;Event;Evolution;Exhibits;experimental study;Future;glycosylation;Half-Life;health of the mother;Human;Human Milk;Humoral Immunities;Immunity;Immunization;Immunoglobulin G;immunoregulation;improved;in vivo;Infant;Infection prevention;Infectious Agent;Influenza;Influenza vaccination;influenza virus vaccine;innovation;Kinetics;Knowledge;Life;Longevity;Maternal antibody;maternal vaccination;Maternally-Acquired Immunity;Measurement;Mediating;Modification;Molecular;Mothers;Mus;Neonatal;offspring;Pertussis;Placenta;Polysaccharides;Population;post pregnancy;postnatal;Postpartum Period;Pregnancy;pregnant;Pregnant Women;prevent;Production;Property;Recommendation;Reporting;response;seasonal influenza;Serology;Serum;Specimen;synergism;System;Systems Analysis;T cell response;T-Lymphocyte;Testing;Tetanus;Vaccinated;Vaccination;vaccination strategy;Vaccine Design;vaccine immunogenicity;vaccine response;vaccine-induced antibodies;vaccine-induced immunity;Vaccines;Woman

PROJECT_TITLE: Maternal Immunity


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Services;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: COLUMBIA

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PUBLIC HEALTH SIGNIFICANCE This study will contribute to public health knowledge of the effects of Medicaid MCO coverage and utilization management design on access to alcohol use disorder treatment, and the effects of Medicaid enrollees’ alcohol use disorder treatment receipt within MCOs on adverse outcomes, namely alcohol-related emergency department visits, hospitalizations, and mortality. The study will provide tangible guidance to states and Medicaid MCO plans regarding how to best structure coverage and utilization management parameters to ensure appropriate and efficient access to alcohol use disorder treatment. 1

PI_NAMEs: ABRAHAM, AMANDA J;ANDREWS, CHRISTINA MARIE (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: access restrictions;Accounting;acute care;Address;Adherence;adverse outcome;Affect;Age;alcohol abuse therapy;alcohol availability;alcohol use disorder;Alcohols;American;AODR mortality;Behavior Therapy;Caring;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;Contracts;craving;Data;Data Set;design;Diagnosis;Emergency department visit;Ensure;evidence base;Health;health knowledge;Health Services Accessibility;Heavy Drinking;Hospitalization;Improve Access;indexing;innovation;Investigation;Kentucky;knowledge base;Link;longitudinal analysis;Managed Care;Medicaid;Methods;Morality;mortality;Ohio;Outcome;Patients;Pharmaceutical Preparations;Policies;Policy Maker;Population;Positioning Attribute;prior authorization;programs;Public Health;public health priorities;Randomized;Recommendation;Relapse;Research;Selection Bias;Series;Structure;Substance Use Disorder;Time;treatment services;United States;Vulnerable Populations

PROJECT_TITLE: Treatment for Alcohol Use Disorder in Medicaid Managed Care

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Hodgkin's Disease;Infectious Diseases;Lymphatic Research;Lymphoma;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PUBLIC HEALTH RELEVANCE Epstein-Barr virus (EBV) is an important cause of human lymphomas, including Hodgkin lymphomas (HLs) and Burkitt lymphomas (BLs), especially in immunosuppressed hosts such as AIDS patients. EBV-infected HLs and BLs have stringent forms of viral latency (types I and II) that cannot transform B cells in vitro, and there are no in vivo models available to study how stringent EBV infection cooperates with activation of oncogenes, or inhibition of tumor suppressor genes (TSGs) to induce BLs and HLs in humans. In this proposal, we will use cord blood-humanized (and non-humanized) mouse models and a novel cell culture system to define mechanisms by which stringent latent EBV infection collaborates with activated oncogenes, inhibited tumor suppressors, and growth signals derived from the tumor microenvironment to drive BL and HL lymphomas.

PI_NAMEs: KENNEY, SHANNON CELESTE (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS-Related Lymphoma;Apoptotic;B-Cell Antigen Receptor;B-Lymphocytes;BCL6 gene;Blood Cells;Burkitt Lymphoma;CD4 Positive T Lymphocytes;Cell Culture System;Cell Culture Techniques;Cell Line;Cells;Collaborations;cyclin D3;EBNA2 protein;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Epstein-Barr Virus-Related Lymphoma;Gene Mutation;Growth;Growth Factor;HIV Infections;Hodgkin Disease;Human;Human Herpesvirus 4;humanized mouse;Immunocompromised Host;immunogenic;In Vitro;in vitro Model;in vivo;in vivo Model;Induction of Apoptosis;infected B cell;interleukin-21;large cell Diffuse non-Hodgkin's lymphoma;LMP1;Lymphocyte;Lymphoma;matrigel;MicroRNAs;Modeling;mouse model;Mus;mutant;Mutation;MYC gene;NF-kappa B;notch protein;novel;Oncogene Activation;Oncogenes;Oncogenic;overexpression;Pathway interactions;Patients;plasma cell differentiation;PRDM1 gene;Pre-Clinical Model;Prevention;Proteins;public health relevance;Retroviridae;Role;Signal Transduction;small hairpin RNA;Small Nuclear RNA;stable cell line;STAT3 gene;Structure of germinal center of lymph node;synergism;TNFRSF5 gene;TNFSF5 gene;transcription factor;transforming virus;tumor;tumor microenvironment;Tumor Suppressor Genes;Tumor Suppressor Proteins;Umbilical Cord Blood;Viral;Viral Proteins;Virus;Virus Latency

PROJECT_TITLE: Stringent Latent Epstein-Barr Virus (EBV) Infection Collaborates with Cellular Gene Alterations to Induce EBV+ Lymphomas

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Understanding the changes that occur to the nervous system during drug abuse is of essential importance if we are to successfully treat addiction. This proposal seeks continued support for the training of graduate students and postdoctoral fellows at the University of Minnesota working in the laboratories of neuroscientists that are dedicated to understanding the neurobiological changes that occur with drug addiction.

PI_NAMEs: MERMELSTEIN, PAUL G (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TITLE: Neuroscience Training in Drug Abuse Research


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breastfeeding, Lactation and Breast Milk;Clinical Research;Immunization;Immunotherapy;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Vaccine Related;Women's Health Research

PI_NAMEs: ACKERMAN, MARGARET E (contact)

PROJECT_TERMS: adaptive immune response;Affect;Affinity;Animal Model;Antibodies;antibody engineering;Antibody Repertoire;Antibody Therapy;antibody transfer;Antigens;Area;Autoimmunity;B cell repertoire;Binding;Biochemical;Biodistribution;Biological;Biology;Biophysics;Birth;Blood;Blood specimen;Breast Feeding;Child;Communicable Diseases;Coupled;critical period;design;Development;Engineering;Evaluation;Fc Receptor;fetal;Fetal health;Fetus;Future;Genomics;Half-Life;Health;high risk;Human;Human Milk;Humoral Immunities;Immunity;Immunoglobulin A;Immunoglobulin G;Immunologics;improved;in utero;In Vitro;in vivo evaluation;in vivo Model;Infant;infant morbidity/mortality;Inherited;innovation;insight;Intrinsic factor;Knowledge;Link;Mass Spectrum Analysis;Maternal antibody;maternal outcome;maternal vaccination;Maternal-fetal medicine;Measurement;Mediating;Medicine;Milk;Modeling;Molecular;molecular phenotype;Monoclonal Antibody Therapy;Morbidity - disease rate;mortality;Mothers;multiple omics;natural antibodies;Natural Immunity;neglect;Neonatal;neonatal Fc receptor;neonatal health;neonatal morbidity;neonate;next generation sequencing;non-Native;novel;novel therapeutics;Outcome;passive antibodies;pathogen;Pathologic;Phenotype;Placenta;Play;postnatal;Pregnancy;Pregnant Women;protective effect;Proteomics;receptor;receptor expression;Recycling;Reporting;Resolution;response;Role;Sampling;Serum;Shapes;Specificity;success;targeted treatment;Techniques;Therapeutic antibodies;Time;tissue culture;tool;Umbilical Cord Blood;unvaccinated;Vaccinated;Vaccination;vaccine development;vaccine immunogenicity;vaccine response;Vaccine Therapy;vaccine-induced antibodies;Vaccines;Variant;Work

PROJECT_TITLE: Transferred Immunity


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: MORGANTOWN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because protein degradation by the proteasome is an essential cellular process and it must function sufficiently for neurons to carry out their biological roles. Alzheimer’s disease is characterized by metastable proteins that are normally degraded by the proteasome, but in disease they missfold and accumulate instead. Determining the molecular mechanisms of why proteins are not properly degraded in Alzheimer’s disease is a critical step that is necessary to understand disease pathogenesis–making this proposal relevant to the part of NIH’s mission that pertains to increasing our understanding of life processes that lays the foundation for advances in disease treatment.

PI_NAMEs: SMITH, DAVID MATTHEW (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: 26S proteasome;abeta oligomer;Address;age related;alpha synuclein;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-42;Amyloid beta-Protein;Animal Disease Models;Animal Model;Binding;Binding Sites;Biochemical;Biological;biophysical techniques;Brain;Caenorhabditis elegans;Cell Culture Techniques;Cell model;Cell Physiology;Cells;Data;Development;Disease;Disease Progression;Disease Resistance;Engineering;experience;Face;Foundations;Genetic;Goals;Human Cell Line;human old age (65+);Hyperactivity;Impairment;In Vitro;in vivo;Individual;innovation;Knowledge;Laboratories;Life;Link;Literature;misfolded protein;Mission;Modeling;Molecular;Molecular Conformation;multicatalytic endopeptidase complex;Mus;mutant;Neuronal Dysfunction;Neurons;neurotoxic;neurotoxicity;novel;Nucleosome Core Particle;Outcome;Pathogenesis;Pathogenicity;Pathologic;pharmacologic;Play;Process;Proteasome Inhibition;protein degradation;Protein Degradation Inhibition;Proteins;proteotoxicity;Public Health;Research;Resistance;Role;Site;small molecule;Synaptic plasticity;Synaptic Transmission;System;tau Proteins;Testing;therapeutic target;tool;Ubiquitin;United States National Institutes of Health

PROJECT_TITLE: Proteasome function in Alzheimer's Disease

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Mental Illness;Neurosciences;Rehabilitation;Stroke

ORG_DEPT: PSYCHOLOGY

PHR: Project Narrative. The breakdown of the conceptual system in the brain in many common neurological and psychiatric disorders, including stroke, dementia, temporal lobe epilepsy, and schizophrenia, has a devastating impact on quality of life. Understanding how this information is organized, represented in the brain, and affected by neuropathology is a major focus of research. The proposed project will study brain regions believed to be crucial for this system, both in healthy subjects and in patients with aphasia due to stroke, leading to insights into the functioning of this system, a critical step in developing effective rehabilitation therapies.

PI_NAMEs: DESAI, RUTVIK H (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Affect;angular gyrus;Anterior;Aphasia;Area;autism spectrum disorder;Brain;brain dysfunction;Brain region;Chronic;combinatorial;Communication;Complex;Decision Making;Dementia;density;Disparate;Distributed Systems;domain mapping;Electrophysiology (science);experimental study;Face;frontal lobe;Goals;Grain;Impairment;Individual;Inferior;insight;Knowledge;Language Disorders;language processing;Left;Lesion;lexical;Life;Link;Maps;Mental disorders;Methodology;Methods;Motor;Motor Cortex;Names;Neighborhoods;Nervous System Disorder;neural;neuroimaging;neuropathology;non-verbal;novel;Parietal Lobe;Patients;performance tests;Persons;phrases;Process;Property;Psychophysiology;Quality of life;rehabilitation strategy;Rehabilitation therapy;Research;Rest;Role;Route;Schizophrenia;segregation;Semantic memory;semantic processing;Semantics;Sensory;Short-Term Memory;social cognition;Social Interaction;Stimulus;Stroke;stroke patient;stroke-induced aphasia;Structure;Structure of middle temporal gyrus;Symptoms;System;Temporal Lobe;Temporal Lobe Epilepsy;Testing;theories;Time;Transcranial magnetic stimulation;treatment strategy;Variant;verbal;Work

PROJECT_TITLE: Semantic Systems

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: CALGARY

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF CALGARY

ORG_STATE: AB

ORG_ZIPCODE: T2N 1N4

PHR: The zoonotic potential of chronic wasting disease (CWD) is unclear to date. We provide the first evidence by transmission experiments to different transgenic mouse models and bank voles that Cynomolgus macaques inoculated via different routes with CWD-positive cervid tissues harbor infectious prions that elicit clinical disease in rodents. Our proposed studies will unravel the properties of these prions, how they will adapt to humans and which pathways are activated in brain cells and associated with clinical disease. Results from these studies uncover the potential manifestation of CWD in humans, which is highly relevant for human health.

PI_NAMEs: GILCH, SABINE ;SCHATZL, HERMANN M (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Address;American;Animals;Asia;Astrocytosis;Biochemical;Biological;Bovine Spongiform Encephalopathy;Brain;brain cell;Cattle;Cell Culture Techniques;cervid;Characteristics;Chronic Wasting Disease;Clinical;Consumption;Data;Deer;Deposition;Disease;Disease Outbreaks;disease transmission;Dissociation;driving force;Eating;Endopeptidase K;epidemiologic data;Europe;Euthanasia;Exhibits;experimental study;Exposure to;Farm;Feces;Goals;Health;Human;human model;humanized mouse;In Vitro;in vivo;Incubated;Infection;innovation;insight;Link;Macaca;Macaca fascicularis;Microtus;Modeling;Molecular;mouse model;Mus;Neurodegenerative Disorders;nonhuman primate;North America;Oral;overexpression;Pathologic;Pathway interactions;Peptide Hydrolases;Persons;Phenotype;Prion Diseases;prion seeds;Prions;Process;Property;Protein Fragment;Protein Isoforms;PrP;PrPSc Proteins;Public Health;reconstitution;Reindeer;Research;Resistance;response;Risk;Rodent;Route;Saliva;single-cell RNA sequencing;Testing;Time;Tissues;Toxic effect;Transgenic Mice;transmission process;Urine;Zoonoses

PROJECT_TITLE: Redefining the zoonotic potential of chronic wasting disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Maternal Health;Pediatric;Pneumonia and Influenza;Prevention;Vaccine Related;Women's Health Research

PI_NAMEs: MARCHANT, ARNAUD  (contact)

PROJECT_TERMS: Adoptive Transfer;Affect;Antibodies;Antibody Response;antibody transfer;Antibody-mediated protection;Avidity;biophysical properties;Biophysics;Birth;Bordetella pertussis;burden of illness;Cells;Characteristics;Child;cohort;common rule;Communicable Diseases;Complement;Computational Biology;Conceptions;Data;Data Analyses;design;Development;Fetus;follow-up;glycosylation;Human;Human Engineering;human model;humanized mouse;IgG1;Immune;Immune response;Immune system;Immunity;Immunization;Immunization Programs;Immunize;Immunobiology;Immunoglobulin G;Immunology;improved;in vitro Model;in vivo;infancy;Infant;Influenza;Influenza vaccination;influenza virus vaccine;influenzavirus;Innate Immune System;innovation;insight;Intervention;Knock-out;Knowledge;Life;Maternal antibody;maternal vaccination;Mediating;Mediator;Methods;Modeling;Molecular;Monoclonal Antibodies;Mothers;mouse model;Names;neglect;Newborn Infant;novel;pathogen;Pertussis;Pertussis Vaccine;Placenta;placental transfer;Polysaccharides;Population;Pregnancy;programs;Property;receptor;Regulation;response;Role;Serology;synergism;System;T cell response;Technology;Vaccination;vaccination strategy;vaccine development;vaccine response;vaccine-induced antibodies;Vaccines

PROJECT_TITLE: Infant Immunity


ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The goal of the University of Michigan (U-M) Pharmacological Sciences Training Program (PSTP) is to develop a diverse pool of well-trained biomedical scientists who have the technical, operational and professional skills required to conduct pharmacological research in an ethically responsible and rigorous manner, and to enter diverse careers in the biomedical research workforce. The competency-based PSTP curriculum is designed to provide trainees with a strong foundational understanding of the pharmacological sciences, to provide training in the performance of rigorous and reproducible research, and to provide career development, teamwork, and leadership training, all under the direction of well-trained and dedicated faculty mentors. Although U-M has individual graduate programs in the Departments associated with this training program, the PSTP is the only program at U-M that draws upon the expertise of faculty, alumni, the Michigan Drug Discovery Institute, and the enthusiasm of students across these units to fertilize interdisciplinary education, collaborative research, career development, and team-based approaches to innovation and translation in target discovery and development of experimental therapeutics.

PI_NAMEs: ISOM, LORI L. (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: pharmacologic;Science;Training

PROJECT_TITLE: Interdepartmental Training in Pharmacological Sciences

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Immunotherapy;Women's Health Research

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE Despite successes seen in treating patients with ER+ breast tumors with endocrine therapies, approximately 33% of these treated patients develop recurrent metastatic tumors that primarily metastasize to bone and do not respond to current treatment options. In the proposed study, we will investigate the Cxcl5/Cxcr2 axis as a primary regulator and potential therapeutic target of metastatic bone colonization. We will evaluate both the mechanism of action of these factors and will determine the efficacy of Cxcr2 inhibitors against metastatic colonization of bone in vivo.

PI_NAMEs: LITTLEPAGE, LAURIE E. (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Animal Model;Animals;antagonist;Architecture;Attenuated;Binding;bisphosphonate;Blood Vessels;bone;Bone neoplasms;Bone remodeling;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;cancer cell;Cancer Etiology;Caring;Cell Proliferation;Cells;Cessation of life;chemokine;Clinical Trials;Coculture Techniques;Combined Modality Therapy;CXCL5 gene;cytokine;Dangerousness;Data;Development;Discontinuous Capillary;Disease;Disseminated Malignant Neoplasm;efficacy evaluation;Endocrine;Environment;ESR1 gene;Estrogen Therapy;Estrogens;Future;Grant;Growth Factor Inhibition;hormone therapy;Human;IL8RB gene;Immune response;immunoregulation;Immunosuppression;Immunotherapy;in vivo;in vivo Model;Inflammation;inhibitor;insight;Interleukin-8B Receptor;Knowledge;Ligands;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;Mammary Neoplasms;Marrow;Mediating;Metastatic breast cancer;Metastatic Neoplasm to the Bone;Metastatic/Recurrent;Methods;mouse model;Mus;Neoplasm Metastasis;Neutrophil Infiltration;osteoclastogenesis;Outcome;Patients;Peptides;Positioning Attribute;pre-clinical;Preclinical Testing;prevent;Primary Neoplasm;Production;Proliferating;receptor;Recombinant Proteins;Recurrent tumor;Research;Resistance;response;Role;Sampling;Signal Transduction;Site;small molecule;Stromal Cells;success;synergism;Testing;Therapeutic;therapeutic target;therapeutically effective;translational potential;Treatment Efficacy;treatment strategy;tumor;Tumor Burden;tumor growth;Woman

PROJECT_TITLE: CXCL5/CXCR2 axis as a therapeutic vulnerability of breast cancer metastasis to bone

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Prevention;Rehabilitation;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CHARLESTON

ORG_DEPT: NEUROLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: PROJECT NARRATIVE Mild Cognitive Impairment (MCI) is a heterogenous syndrome of cognitive and neuropsychiatric symptoms, with as much as 40% of patients being diagnosed with comorbid depression. The goal of this project is to establish the dose-response curves of a safe and clinically feasible non-invasive brain stimulation technique (intermittent theta-burst repetitive transcranial magnetic stimulation [iTBS-rTMS]) to improve both depression and cognitive function in MCI patients with comorbid depression. These results will inform future clinical trials of iTBS-rTMS for MCI such that the optimal dose can be used when targeting dysfunction in shared brain circuitry underlying both cognitive and neuropsychiatric symptoms, with the long-term goal of developing an efficacious treatment to prevent dementia.

PI_NAMEs: BENITEZ, ANDREANA  (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Acceleration;Address;Affect;Affective;affective neuroscience;Affective Symptoms;Aftercare;Alzheimer's disease related dementia;amnestic mild cognitive impairment;Attention;Behavior Therapy;Biometry;brain circuitry;brain magnetic resonance imaging;Cerebrovascular Disorders;Clinic;Clinical;Clinical assessments;Clinical Trials;Cognition;Cognition Disorders;Cognitive;cognitive ability;cognitive control;Cognitive deficits;cognitive function;combinatorial;Communities;comorbid depression;comorbidity;Data;Dementia;dementia risk;design;Diagnosis;Diagnostic;Diagnostic Specificity;Disease remission;Dorsal;Dose;Double-Blind Method;DSM-V;efficacious treatment;Ensure;FDA approved;Functional disorder;Functional Magnetic Resonance Imaging;Future;geriatric depression;Goals;Health Care Costs;Heterogeneity;improved;Incidence;innovation;Intervention;Left;Liquid substance;Mental Depression;Methods;mild cognitive impairment;neural circuit;Neurobehavioral Manifestations;Neurocognitive;Neuronal Plasticity;neuropathology;neuropsychiatric symptom;neuropsychiatry;Neuropsychology;noninvasive brain stimulation;open label;Participant;Patients;Phase;phase I trial;phase II trial;Physiologic pulse;Prefrontal Cortex;prevent;primary outcome;progression risk;Psychometrics;Randomized;Randomized, Controlled Trials;recruit;Regulation;remediation;repetitive transcranial magnetic stimulation;response;Safety;Scheme;secondary outcome;Secondary Prevention;Site;Stroke;Symptoms;Syndrome;Techniques;Testing;Therapeutic;Transcranial magnetic stimulation;treatment duration;United States National Institutes of Health;Variant;Vascular Cognitive Impairment;Visual;Work

PROJECT_TITLE: Transcranial Magnetic Stimulation for MCI: A Phase II Dose-Response Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(91)S]


NIH_SPENDING_CATS: Biotechnology;Genetics;Immunization;Maternal Health;Pediatric;Prevention;Vaccine Related;Women's Health Research

PI_NAMEs: TSANG, JOHN S (contact)

PROJECT_TERMS: Address;Affect;Age;Antibodies;Antibody Repertoire;Antibody Response;antibody transfer;Cells;Chromatin;cohort;Communities;Computer Analysis;data resource;Dendritic Cells;design;Dissection;empowerment;Environment;Epigenetic Process;Fc Receptor;Funding;Genetic;Genetic Transcription;glycosylation;Human;imaging approach;Immune;Immunity;Immunization;Immunology;improved;Individual;infancy;Infant;Infant Mortality;Infection;Influenza;insight;Interferon Type I;Interferons;Intramural Research Program;Knowledge;Life;Link;Machine Learning;Maternal antibody;maternal vaccination;Measures;Membrane Proteins;Molecular;Mothers;mouse model;multimodality;Neonatal Mortality;Newborn Infant;Outcome;Pathway interactions;Peripheral;Peripheral Blood Mononuclear Cell;Phenotype;Physiological;Population;postnatal;Pregnancy;pregnant;Pregnant Women;Process;receptor binding;Recording of previous events;Research;Resolution;response;Serology;sex;Shapes;synergism;System;Technology;Therapeutic;Time;Tissue imaging;transcriptome;United States National Institutes of Health;Vaccination;vaccine response;vaccine-induced antibodies;Vaccines

PROJECT_TITLE: Systems Immunology


NIH_SPENDING_CATS: Aging;Diabetes;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Much of our knowledge of islet physiology stems from rodent studies, however, we now know that marked differences exist between rodent and human islets in regard to architecture, hormone secretion, and islet cell enriched transcription factor expression, demonstrating potential limitations in assuming that rodent models entirely mimic human islet physiology and disease. An example of such a discrepancy lies in the islet cell enriched MAFA transcription factor, a fundamentally important protein in rodent islet β cells that is not even produced in human islet β cells until ~9 years of age. We hypothesize that this TF plays an essential role in regulating human insulin secretion in adults, and will test this in two distinct experimental contexts, human embryonic stem cell-derived β cells and adult human islets.

PI_NAMEs: HEBROK, MATTHIAS ;STEIN, ROLAND W (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: 9 year old;Acute;Adolescent;Adult;Affect;age difference;age related;Aging;Architecture;Beta Cell;Biochemical;Biological Assay;Birth;Cell Aging;Cell Cycle Arrest;Cell Maturation;Cell Physiology;Cells;Chronic;Cytoplasm;Development;Diabetes Mellitus;Disease;disease-causing mutation;DNA Damage;Embryo;endocrine pancreas development;epigenomics;euglycemia;expectation;experimental study;Female;Functional disorder;Gene Expression;Genes;Glucose;Glucose Intolerance;Gold;Grant;Health;Heterozygote;Hormone secretion;Human;human embryonic stem cell;human female;human pluripotent stem cell;human stem cell-derived;human subject;Hypoglycemia;Immunocompromised Host;improved;In Vitro;in vivo;induced pluripotent stem cell;innovation;insight;Insulin;insulin secretion;insulinoma;islet;Islet Cell;knock-down;Knock-out;Knowledge;Left;Life;life span;Link;male;Mediating;Mediator;men;Molecular;mouse model;Mus;mutant;Mutation;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear;outcome prediction;overexpression;p53-binding protein 1;Pathogenesis;Pathologic;Phenotype;Phenylalanine;Physiological;Physiology;Play;Population;postnatal;premature;Premature aging syndrome;Production;Property;Proteins;Qualifying;Reporting;response;Rodent;Rodent Model;Role;senescence;senescence associated secretory phenotype;Serine;sex;Sex Bias;Stains;stem;Testing;transcription factor;transcriptome sequencing;Transplantation;type I and type II diabetes;Variant;Woman

PROJECT_TITLE: Defining the role of MafA in islet beta cells

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative These studies leverage mammalian cell genetics to make fundamental contributions to the fields of membrane biology, intracellular lipid transport, LDL receptor function/endocytosis, the SREBP pathway, and regulation of lipid synthesis. Given that modulation of cholesterol synthesis and LDL receptor function are primary interventions in the treatment of hypercholesterolemia, these studies may identify new therapeutic targets for the prevention of heart disease.

PI_NAMEs: ESPENSHADE, PETER J. (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Address;Adult;Cell membrane;Cell Physiology;Cells;Cellular biology;Cholesterol;CRISPR/Cas technology;Endocytosis;Fatty Acids;fluidity;forward genetics;Genes;Genetic;heart disease prevention;Homeostasis;Human;hypercholesterolemia;Integral Membrane Protein;Intervention;Learning;lipid transport;Lipids;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Mammalian Cell;Membrane;Membrane Biology;Membrane Lipids;model organism;new therapeutic target;Pathway interactions;Permeability;Proteome;receptor function;Regulation;Research;United States

PROJECT_TITLE: Regulation of Membrane Lipid Homeostasis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Heart Disease;Mental Health;Neurodegenerative;Rehabilitation

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Should this study demonstrate that, by improving cognitive function and interoceptive awareness, phone- delivered mindfulness training improves the ability of patients with heart failure and mild cognitive impairment to effectively implement self-care, this accessible and scalable intervention could be integrated into rehabilitation programs and self-care interventions to improve clinical outcomes in this vulnerable population.

PI_NAMEs: SALMOIRAGO-BLOTCHER, ELENA  (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: Address;Affect;age group;Aging;aging population;Attention;Awareness;Biological Markers;Cardiac;Cellular Phone;cerebral hypoperfusion;Cerebrovascular Disorders;Chronic;Clinical;Cognition;cognitive function;cognitive performance;comorbidity;Death Rate;design;Diagnosis;digital;Educational Materials;Electronics;Ensure;Event;follow-up;Health Care Costs;Heart failure;hospital readmission;Hospitals;Impaired cognition;improved;Individual;innovation;interest;Interoception;Intervention;Intervention Studies;Investigation;Knowledge;Life Style;Link;Mediating;medical attention;mild cognitive impairment;Mindfulness Training;Monitor;multiple chronic conditions;National Institute on Aging;older adult;Outcome;Outpatients;pandemic disease;Participant;Pathway interactions;Patient Education;Patients;pharmacologic;Phase;Physiological;Population;prevent;Printing;Prognosis;programs;Randomized;Recommendation;Rehabilitation therapy;Relaxation;response;Role;Self Care;Self Management;Signal Transduction;skills;Symptoms;Telephone;Testing;treatment as usual;United States;Vulnerable Populations;Work

PROJECT_TITLE: Targeting cognitive function and interoceptive awareness to improve self-management in patients with co-morbid heart failure and cognitive impairment.

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences;Stimulant Use and Misuse

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

ORG_STATE: NY

PHR: Dopamine D2 receptors are the targets of all antipsychotic drugs currently available, but we lack fundamental knowledge as to which specific receptors in the brain must be blocked to achieve antipsychotic effects and which contribute to side effects. Emerging evidence suggests that D2 receptors can interact with other receptors in the brain to modulate their functional properties, creating potential new approaches to more targeted therapeutics. The molecular studies proposed in cells, brain slices, and ultimately in behaving mice will lead to improved understanding of how the function of these receptors is modulated by receptor interactions.

PI_NAMEs: JAVITCH, JONATHAN A (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: ADORA2A gene;Agonist;Antipsychotic Agents;Attention;Autopsy;Behavior;Biological Assay;Brain;Brain region;Cell membrane;cell type;Cells;Cocaine;comparison control;Complex;conditioned place preference;Corpus striatum structure;density;design;dimer;Dimerization;Dopamine;Dopamine D2 Receptor;Dopamine Receptor;drug action;Excitatory Synapse;Exhibits;experimental study;extracellular;Fluorescence;Functional disorder;G-Protein-Coupled Receptors;glutamatergic signaling;Goals;Grant;Heterodimerization;Homo;Human;imaging modality;Imaging Techniques;improved;In Vitro;in vivo;Individual;interest;Investigation;Kinetics;Knowledge;Ligation;Literature;Maintenance;Mammalian Cell;Measurement;Mediating;Membrane;Methods;Molecular;molecular scale;Molecular Target;monomer;mu opioid receptors;Mus;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;neuronal excitability;Neurons;new therapeutic target;novel;novel strategies;novel therapeutics;Physiologic pulse;Physiological;Physiology;Play;Population;postsynaptic;Property;Protomer;Psychoses;receptor;Receptor Activation;receptor density;receptor expression;receptor function;Reporting;Resolution;response;Rodent;Role;Schizophrenia;secretin receptor;side effect;Signal Transduction;single molecule;single-molecule FRET;Slice;Spectrum Analysis;stimulant exposure;stimulant user;Structure;targeted treatment;Therapeutic;therapeutically effective;Time;tool;Ventral Striatum;Viral

PROJECT_TITLE: Structure and Function of Dopamine Receptors

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


ORG_CITY: SANTA CRUZ

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

ORG_STATE: CA

PHR: NARRATIVE The goal of this R01 proposal is to use our stabilized Amyloid beta forms to uncover novel uptake-toxicity relationships to better understand Alzheimer’s Disease. Peptide synthesis, biophysical and cell culture experiments performed in the Raskatov lab will be combined with collaborative efforts with the Tycko lab (NIH) and the Eisenberg lab (UCLA), which may allow us to obtain experimental structures of Amyloid beta trapped in both toxic and non-toxic states. Research proposed may lead to future development of Alzheimer’s therapeutics that act as structural modifiers that convert Amyloid beta into a non-toxic state.

PI_NAMEs: RASKATOV, JEVGENIJ  (contact)

PROJECT_TERMS: abeta accumulation;abeta oligomer;abeta toxicity;Aducanumab;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease therapeutic;Amino Acid Substitution;Amyloid beta-42;Amyloid beta-Protein;amyloid structure;beta pleated sheet;Binding;Biological Assay;Biophysics;Brain;Cell Culture Techniques;Clinical Trials;Collaborations;Consult;Cryoelectron Microscopy;Data;Deposition;Development;experimental study;extracellular;Future;Goals;Hydrophobicity;Image;improved;innovation;insight;Knowledge;Link;Location;Measures;Methods;Molecular;Molecular Conformation;N-terminal;Neurobiology;Neurons;neurotoxic;neurotoxicity;novel;Pathogenicity;peptide P3;Peptide Synthesis;Peptides;Pharmaceutical Preparations;pre-clinical;Process;protein aggregation;Research;Resolution;Sampling;Site;solid state nuclear magnetic resonance;Structure;Testing;tool;Toxic Actions;Toxic effect;Translating;United States National Institutes of Health;uptake;Variant;Work

PROJECT_TITLE: Using Chirality to Understand and Control Amyloid Beta Neuronal Uptake and Toxicity

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Aging;Biotechnology;Nutrition

PHR: NARRATIVE STATEMENT Caloric restriction (CR) in animals increases lifespan and reduces disease burden. Since aging is a major risk factor for chronic diseases the mechanism whereby dietary interventions can lower disease has high public health relevance. This project is designed to study caloric restriction in humans to discover new anti- inflammatory targets that drive the salutary effects of CR on healthspan.

PI_NAMEs: DIXIT, VISHWA DEEP (contact)

PROGRAM_OFFICER_NAME: YUAN, JEAN

PROJECT_TERMS: Acute;Adipocytes;Adipose tissue;Age;age related biomarkers;age related chronic disease;Aging;aging clocks;Alzheimer's Disease;Ancillary Study;Animals;Anti-Inflammatory Agents;aptamer;arm;biomarker discovery;Biopsy;burden of illness;Caloric Restriction;Cause of Death;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Nucleus;Cells;cellular targeting;Cessation of life;Chronic Disease;Clinical;Clinical Trials;clinically relevant;Data;design;Dietary Intervention;Disease;early onset;energy balance;Energy Intake;extend lifespan;extracellular;Funding;Genetic Transcription;Goals;Growth;Health;Health Care Costs;healthspan;Human;human old age (65+);Human Volunteers;Immune;Immune response;Immune system;Immunity;Impairment;improved;Individual;Inflammation;Inflammatory;Influenza;insight;Interdisciplinary Study;Intervention;life span;Long-Term Effects;Longevity;Measures;Metabolic;metabolome;mimetics;Modeling;mortality;Mouse Strains;Mus;Myeloid Cells;neuronal cell body;novel;Outcome;Parasitic infection;Participant;Pathway interactions;Persons;Physiology;Plasma;polymicrobial sepsis;Population;Primates;programs;Protein Secretion;Proteins;Proteomics;public health relevance;Rana;Recording of previous events;Rejuvenation;Reproduction;Reproductive system;response;Risk Factors;RNA;Rodent;Role;Sampling;Serum;Signal Transduction;single nucleus RNA-sequencing;System;Technology;Testing;theories;Therapeutic;thymocyte;Thymus Gland;Time;Tissues;transcriptome;transcriptome sequencing;West Nile viral infection

PROJECT_TITLE: Caloric restriction-driven immunometabolic checkpoints of inflammation

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Myoblast fusion is essential for skeletal muscle development and regeneration. Understanding the mechanisms of myoblast fusion will lead to significant insights into human muscle biology in health and disease, and ultimately provide a basis for optimizing muscle stem cell-mediated therapeutics against life debilitating muscle degenerative diseases.

PI_NAMEs: CHEN, ELIZABETH H (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Actins;Animals;Biochemical;Biological;Biology;Cell Adhesion Molecules;Cell membrane;Cell Therapy;Cells;congenital myopathy;Cytoskeleton;Defect;Degenerative Disorder;Development;Disease;Drosophila genus;Electron Microscopy;Embryo;Event;Exhibits;F-Actin;Future;Genes;Genetic;Health;Human;Image;in vivo;in vivo Model;insight;Invaded;Knowledge;Life;Location;Maintenance;Mass Spectrum Analysis;Mechanics;Mediating;Membrane;Membrane Fusion;Modeling;Molecular;molecular marker;mouse model;Mus;Muscle;Muscle Development;Muscle Fibers;muscle physiology;muscle progenitor cell;muscle regeneration;Muscle satellite cell;mutant;Myoblasts;Myopathy;Natural regeneration;novel;Orthologous Gene;Patients;polymerization;Polymers;Process;Property;Proteins;sensor;Site;Skeletal Muscle;System;Testing;Therapeutic;therapeutic development;ultra high resolution;Vertebrates;Visualization;Zebrafish

PROJECT_TITLE: Investigating mechanisms of vertebrate myoblast fusion using zebrafish as a model