NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: VANCOUVER

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF BRITISH COLUMBIA

ORG_STATE: BC

ORG_ZIPCODE: V6T 1Z3

PHR: PROJECT NARRATIVE This study will employ a community-engaged approach to adapting, producing, and pilot testing a written youth overdose prevention “toolkit” for use by clinicians in pediatric healthcare settings, and will be conducted in Boston, MA, and Vancouver, Canada, two locales that are highly impacted by the overdose crisis and have been instrumental in developing and disseminating world-leading youth substance use interventions. The toolkit will be comprised of practical and easy to use guidance for delivering the following evidence-based core elements: naloxone and take-home drug testing strips, harm reduction education, and medications for opioid use disorder (i.e., buprenorphine, methadone, or naltrexone). The result of the project will be an optimized toolkit developed with extensive youth, caregiver, and clinician input that is practical and easy to use, developmentally appropriate and youth- and caregiver-centered.

PI_NAMEs: FAST, DANYA  (contact);HADLAND, SCOTT EVAN

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adolescent and Young Adult;adolescent substance use;Adult;Affect;Age;arm;Behavioral;Black race;Black, Indigenous, People of Color;Boston;British Columbia;Buprenorphine;Canada;Caregivers;Caring;Cause of Death;Characteristics;Child health care;Childhood;Cities;Collaborations;Communities;community advisory board;community clinic;community engaged approach;Death Rate;Development;Diagnosis;Discrimination;Disparity;drug testing;Drug usage;Education;Elements;evidence base;Evidence based intervention;experience;Face;Family member;Feedback;fentanyl test;field study;Fostering;Gender;Harm Reduction;health care settings;health disparity;Health Services Accessibility;Health system;Home;Hospitals;Hour;housing instability;Illicit Drugs;implementation framework;Improve Access;improved;Incidence;Indigenous;Individual;Infrastructure;Institutional Racism;International;Intervention;Interview;Knowledge;Lesbian Gay Bisexual Transgender Queer;Lived experience;Locales;Measures;medication for opioid use disorder;meetings;member;Methadone;Naloxone;Naltrexone;National Institute of Drug Abuse;North America;opioid use;opioid use disorder;Outcome;Overdose;overdose death;overdose prevention;Overdose reduction;Overdose reversal;Pattern;people of color;Pharmaceutical Preparations;Phase;Physicians;Pilot Projects;pilot test;Play;poor health outcome;Population;prevent;preventive intervention;primary outcome;Production;Provider;Province;Psychiatrist;Race;Recommendation;Research;Role;Sampling;Sexuality;skills;Social isolation;social stigma;Socioeconomic Status;Structure;substance use;Surveys;test strip;Testing;Training;US State;Variant;Work;Writing;Youth

PROJECT_TITLE: Adapting and Testing a Youth Overdose Prevention Toolkit

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 CEM-E (O1)]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LITTLE ROCK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Project Narrative The current proposal for a Team Science Administrative Supplement is associated and directly in line with the goals of the Center for Microbial Pathogenesis and Host Inflammatory Responses (CMPHIR; P30 GM145393; PD: Mark Smeltzer, Ph.D.), in that it takes a comprehensive, team-based approach to understanding how the crosstalk between microbiota and the host during antibiotic-induced dysbiosis, so that new therapeutic strategies can be implemented to maintain host homeostasis and mitigate disease risk. This supplement will facilitate the development of a strong collaborative team with complementary skillsets and experimental approaches, thus allowing for a unique and comprehensive experimental approach that would not otherwise be possible.

PI_NAMEs: SMELTZER, MARK S (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Acceleration;Acute;Address;Administrative Supplement;Affect;Ampicillin;angiogenesis;Antibiotics;Applications Grants;Area;Arkansas;authority;Bacteria;Beds;Biological;Biology;Blood Vessels;career development;CD36 gene;Cell Line;cell motility;Cell Physiology;Cell Survival;cell type;Cells;Cellular biology;Centers of Research Excellence;Child Nutrition;Chronic;Ciprofloxacin;Clinical;Collaborations;commensal microbes;Communicable Diseases;Complex;Core Facility;Data;Development;differential expression;Discipline;Disease;disorder risk;Distal;Distant;Doctor of Philosophy;dysbiosis;Endothelial Cells;Equation;Equipment;experience;extracellular;Extracellular Matrix;extracellular vesicles;Extramural Activities;Fatty Acids;Feces;fighting;Foundations;Funding;Future;Gastrointestinal tract structure;Goals;Growth;Homeostasis;Homing;Human;Immune;Immune response;In Vitro;in vivo;Individual;infancy;Infection;Inflammatory Response;Innate Immune Response;Innate Immune System;Institution;interest;Investigation;Laboratories;lipid metabolism;lipidomics;Lipids;Lipoproteins;Liquid substance;Location;Mammalian Cell;Medical;Membrane;metabolomics;Metronidazole;microbial;microbial community;microbiota;Molecular;mouse model;multiple omics;mutational status;Natural Immunity;Neomycin;neutrophil;Neutrophil Activation;novel therapeutic intervention;Nucleic Acids;Nutritional Study;Oral;parent project;Parents;particle;pathogen;Pathogenesis;pathogenic microbe;Pathology;Patients;Pediatric Hospitals;Phase;Process;Proteomics;Protocols documentation;Publishing;Reporting;Research;Research Infrastructure;Research Institute;Research Personnel;Resources;Risk;RNA Transport;scavenger receptor;Science;Serum;Side;skills;Small RNA;Solid Neoplasm;synergism;Technology;Testing;therapy outcome;tool;translocase;Trimethoprim-Sulfamethoxazole;tumor;Tumor Angiogenesis;tumor progression;Universities;unpublished works;Vancomycin;vascular bed;Vascular Endothelial Cell;virtual;Work


ADMINISTERING_IC: DC

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Hearing Loss;Neurosciences

ORG_CITY: Los Angeles

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE With approximately 430 million people worldwide suffering from hearing loss, it is a matter of high priority to provide clinicians and researchers with tools that can accurately assess the functional and physiological conse- quences of sensory damage. By innovating recordings of electrical potentials of the inner ear, the proposed project aims to address this pressing need by creating a precise diagnostic test that can assess the function of the sensory cells as well as determine the site of the insult both longitudinally and within the sensory epithelia. Results of the proposed work will help to develop and test the effectiveness of pharmacological, genetic and technological interventions aimed at restoring normal inner ear processing in cases of sensory hearing loss.

PI_NAMEs: CHARAZIAK, KAROLINA  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Action Potentials;Address;Affect;Aging;Amplifiers;Automobile Driving;cell injury;Cells;Centers for Disease Control and Prevention (U.S.);Chronic;Clinical;Cochlea;Congenital Abnormality;Development;Diabetes Mellitus;Diagnosis;Diagnostic tests;DNA Sequence Alteration;Drops;effectiveness testing;electric field;electrical potential;Epithelium;Etiology;Exhibits;Frequencies;gene therapy;Generations;Genetic;Goals;Growth;Hearing;hearing impairment;hearing range;Hearing Tests;Human;improved;individualized medicine;innovation;Intervention;Labyrinth;Length;Location;Malignant Neoplasms;Measures;Motion;Mus;Names;Nature;Noise;notch protein;Optical Coherence Tomography;Organ of Corti;otoacoustic emission;ototoxicity;Outer Hair Cells;Perception;personalized diagnostics;Persons;Pharmaceutical Preparations;pharmacologic;Physiological;Play;Prevalence;Process;Property;Psychoacoustics;Receptor Cell;Research;Research Personnel;response;Role;screening;Sensorineural Hearing Loss;Sensory;Shapes;Site;sound;Specificity;Stimulus;Sum;Syncope;Technology;technology intervention;Testing;tool;vibration;voltage;Work

PROJECT_TITLE: Gain-sensitive cochlear microphonics - a diagnostic test of functional and physiological effects of sensory hearing loss

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: RIVERSIDE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative Stroke is a leading cause of serious, long-term disability, and the fifth leading cause of death in the United States. The proposed research aims to provide a novel solution to personalized endovascular embolization of brain aneurysms, which will allow for optimal aneurysmal space filling and longer-lasting complete occlusion based on the guidance provided by the developed integrated experimental-computational approach. The anticipated shift in the clinical treatment paradigm will lead to improved long-term treatment outcomes and reduced in-hospital expenditure for managing aneurysm rupture-induced hemorrhagic stroke.

PI_NAMEs: LEE, CHUNG-HAO  (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: 3-Dimensional;3D Print;Accounting;Acute;Affect;American;Aneurysm;Animals;Arteries;Biomechanics;Brain;Brain Aneurysms;Brain hemorrhage;Brain Injuries;Calibration;Catheters;Cause of Death;Circulation;Classification;Clinical;Clinical Treatment;Collaborations;compare effectiveness;Complex;Data;Death Rate;design;Development;Devices;Dilatation - action;Effectiveness;Elastases;Elements;Evaluation Studies;Expenditure;experience;experimental study;fabrication;Gel;Geometry;Goals;hemodynamics;Hospitals;Implant;improved;improved outcome;in silico;In Vitro;in vivo;Incidence;Indiana;Individual;Intracranial Aneurysm;iterative design;Left;Liquid substance;Long term disability;manufacture;manufacturing process;mechanical properties;Mechanics;Medicine;Memory;Methods;microdevice;minimally invasive;Modeling;Morphology;Neck;Nervous System Disorder;neurosurgery;New Zealand;novel;Oklahoma;Oryctolagus cuniculus;Patients;Performance;Polymers;Porosity;Premature Mortality;prevent;Preventive;Printing;Process;Property;prophylactic;Protocols documentation;Recovery;Recurrence;Reporting;Research;Research Personnel;Residual state;Retreatment;Rupture;Ruptured Aneurysm;Sampling;Science;Shapes;Stroke;Structure;Subarachnoid Hemorrhage;System;Techniques;Testing;Therapeutic Embolization;thrombogenesis;Tissues;translational medicine;Treatment outcome;United States;Universities;Urethane

PROJECT_TITLE: Improving outcomes in endovascular treatment of intracranial aneurysms: Combining additive manufacturing, in-silico modeling, and shape memory polymers

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: Wauwatosa

ORG_NAME: RETHAM TECHNOLOGIES, INC.

ORG_STATE: WI

PHR: PROJECT NARRATIVE Heparin-induced thrombocytopenia (HIT) is a life-and-limb threatening complication of heparin treatment, but current HIT diagnostic tests are either non-specific or too technically complex. The goal of this project is to develop a technically simple and accurate in vitro diagnostic (IVD) assay to enable timely treatment for better patient outcomes.

PI_NAMEs: JONES, CURTIS  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Adverse reactions;Antibodies;antibody detection;Anticoagulants;Binding;Biological Assay;Biometry;Blinded;Blood Platelets;Clinical Research;clinically significant;Complex;Complication;Coupled;COVID-19 complications;COVID-19 vaccine;Detection;detection assay;Development;Diagnosis;diagnostic assay;Diagnostic tests;Enzyme-Linked Immunosorbent Assay;Family;Future;Goals;Hemorrhage;Heparin;heparin-induced thrombocytopenia;hospital laboratories;Hospitalization;in-vitro diagnostics;Laboratories;Legal patent;Life;Limb structure;member;Methods;novel;Pathogenicity;Patient-Focused Outcomes;Patients;Performance;PF4 Gene;Phase;Physicians;Platelet Activating Factor;Platelet Activation;polyanion;Predictive Value;prospective;prototype;Research;Serotonin;Small Business Innovation Research Grant;Technology;Testing;Thrombocytopenia;thrombotic;Vaccines

PROJECT_TITLE: An in vitro diagnostic assay for the early and accurate detection of platelet-activating antibodies associated with Heparin-induced Thrombocytopenia


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Prevention

ORG_CITY: ROCKVILLE

ORG_NAME: IQ SOLUTIONS, INC.

ORG_STATE: MD

PI_NAMEs: QUINTAS, ILEANA  (contact)

PROJECT_TERMS: Caring;Contractor;Contracts;craniofacial;Dental;design;Development;Disease;Exhibits;Information Centers;Maintenance;Mission;National Institute of Dental and Craniofacial Research;operation;Oral;Oral health;Patients;Prevention strategy;Production;Research;Resources;response;Services;website development

PROJECT_TITLE: SERVICES TO OPERATE NIDCR NATIONAL ORAL HEALTH INFORMATION CENTER


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: ALEXANDRIA

ORG_NAME: NATIONAL CANCER REGISTRAR'S ASSOCIATION

ORG_STATE: VA

PI_NAMEs: SWAIN, LORI  (contact)

PROJECT_TERMS: Data;Educational workshop;Feasibility Studies;Registries;Training;web site

PROJECT_TITLE: SEER TRAINING WEBSITE, NEW DATA ITEM FEASIBILITY STUDY, AND SEER ADVANCED TOPICS FOR REGISTRY PROFESSIONALS WORKSHOP TECHNICAL AND LOGISTICAL SUPPORT


ORG_CITY: CHICAGO

ORG_NAME: IIT RESEARCH INSTITUTE

ORG_STATE: IL

PI_NAMEs: MCCORMICK, DAVID  (contact)

PROJECT_TERMS: cancer therapy;Clinical Trials;Contracts;Data;Disease;Government;Human;Investigational Drugs;Malignant Neoplasms;Pharmaceutical Preparations;pre-clinical;Principal Investigator;Property;Toxicology

PROJECT_TITLE: PRECLINICAL TOXICOLOGY OF LARGE MOLECULE DRUGS DEVELOPED FOR CANCER AND OTHER INDICATIONS


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Colorectal Cancer;Digestive Diseases;Genetics

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PI_NAMEs: MALANEY, PRERNA  (contact)

PROJECT_TERMS: Attenuated;Binding Proteins;Biological Process;cancer initiation;Cetuximab;Clinical;colon cancer patients;Colorectal Cancer;Data;Disease;Genetic;Heme;Individual;insight;Investigation;Lesion;Malignant Neoplasms;malignant phenotype;Missense Mutation;mutant;Mutate;Mutation;novel;Oncogenic;Outcome;Pathogenicity;Pathway interactions;Patient Care;Poly C;Recurrence;Relapse;resistance mechanism;RNA Recognition Motif;RNA-Binding Proteins;Role;Signal Pathway;Signal Transduction;Solid;Therapeutic;Therapeutic Intervention;tumor;tumor progression;Tumor Suppressor Proteins

PROJECT_TITLE: Understanding the role of RNA-binding protein mutations in cancer


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Mental Health;Opioid Misuse and Addiction;Opioids;Prevention;Recovery Support Services;Rehabilitation;Substance Misuse

ORG_CITY: BLOOMINGTON

ORG_NAME: CHESTNUT HEALTH SYSTEMS, INC.

PHR: Project Narrative This study aims to test PATH (Peer Advanced Training in Harm reduction) as a system-level workforce intervention for reducing burnout among peer recovery support specialists (PRSSs) who provide harm reduction (HR) services, as well its ability to improve service quality and service system-level outcomes. PATH addresses a recognized need to support the national expansion of PRSS and HR services to support people with substance use disorders and reduce overdose rates. If successful, PATH can serve as a model program to be scaled nationally.

PI_NAMEs: WATSON, DENNIS PAUL (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Abstinence;Acceleration;Address;Behavior;burnout;Case Based Learning;Case Study;case-based;Certification;Client;cohort;Communities;community based participatory research;community partners;Consultations;Continuing Education;cost effectiveness;Credentialing;Data;design;Development;Disease;Disease Progression;Drug Controls;Drug usage;E-learning;Education;Effectiveness;effectiveness testing;Ensure;Epidemic;evidence base;experience;Foundations;Goals;Harm Reduction;Helping to End Addiction Long-term;improved;Indiana;Individual;Intervention;Lead;Lived experience;Mental Health;Mentors;methamphetamine use;Methods;Modeling;Motivation;Occupations;Opiate Addiction;Opioid;opioid misuse;opioid use;opioid use disorder;Outcome;Overdose;Overdose reduction;overdose risk;peer;peer recovery;peer support;Performance at work;Persons;Pharmaceutical Preparations;Phase;population health;primary outcome;Process;professional atmosphere;programs;Protocols documentation;Provider;Public Health;Randomized;Recovery;recovery community organization;recovery services;Recovery Support;recruit;Relapse;Research;Resources;response;Risk;Role;Sampling;service delivery;Services;Social support;Specialist;Speed;stimulant use disorder;Strategic Planning;substance use;Substance Use Disorder;success;System;Testing;theories;Time;Training;transmission process;United States National Institutes of Health;uptake;virtual education;Work

PROJECT_TITLE: PATH to reducing burnout among peers who deliver harm reduction services: Improving workforce and service system outcomes through a combined eLearning and group consultation intervention

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKP-E (O1)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Mental Illness;Opioid Misuse and Addiction;Opioids;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE COUNTY

PHR: Project Narrative Posttraumatic stress disorder (PTSD) and opioid use disorder (OUD) often co-occur, but treatment for PTSD is rarely available in residential substance use disorder (SUD) treatment settings. Written Exposure Therapy (WET) is a brief, evidence-based intervention for PTSD that shows promise for treating people with OUD in residential SUD care. With stakeholder collaboration, we will create and test a theory-driven adaptation of WET to address PTSD-OUD in residential SUD care, thereby advancing knowledge of practical strategies that are crucial for addressing the opioid use crisis.

PI_NAMEs: SCHACHT, REBECCA L (contact);WENZEL, KEVIN R.

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: access restrictions;Acute;Address;Behavior;behavioral health;Caring;Catalogs;Client;Cognitive;Collaborations;comorbidity;Data;design;Dropout;Effectiveness;efficacy evaluation;Elements;Enrollment;Event;evidence base;Evidence based intervention;Evidence based treatment;experience;Feedback;follow-up;Healthcare;Hour;improved;Individual;Intervention;Investigation;Knowledge;knowledge base;Life;Manuals;Mediator;Mental Health;Modeling;Modification;Opioid;opioid epidemic;opioid overdose;opioid use;opioid use disorder;Outcome;overdose death;overdose risk;Participant;Patients;Persons;Phase;Pilot Projects;pilot test;post intervention;Post-Traumatic Stress Disorders;preference;primary outcome;Protocols documentation;Public Health;Qualifying;Randomized;Randomized, Controlled Trials;reduce symptoms;relative effectiveness;Research;Research Project Grants;Residential Treatment;sexual assault;Site;Specific qualifier value;Stressful Event;Structure;Substance Use Disorder;suicidal;Symptoms;Testing;theories;Time;Training;traumatic event;Work;Writing

PROJECT_TITLE: Treating OUD/PTSD in Residential Care: Written Exposure in Substance Treatment (WEST).


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Mental Health;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE This project will contribute to our understanding of the ways in which non-congregate forms of housing shelter may improve the mental health outcomes of people through service delivery by healthcare-community housing partnerships. Traditionally, shelter options provided for this population have been congregate, but during the early years of the COVID-19 pandemic, congregate shelter residents were moved to non-congregate spaces like hotels to minimize the spread of the disease. As those policies expand and evolve, it is essential that we learn about the impact they had on mental health, to inform future housing policies.

PI_NAMEs: HARPER, ANNIE ;WONG, AMBROSE H (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Accident and Emergency department;Address;Alabama;Attention;Behavioral;Black race;Caring;Cities;Collaborations;Communities;community based participatory research;community engagement;Community Health;community partnership;Computerized Medical Record;Connecticut;COVID-19;COVID-19 pandemic;Data;Data Collection;Data Set;Data Sources;design;development policy;Disease;electronic data;Electronic Health Record;Eligibility Determination;Emergency Department patient;Emergency department visit;Emergency Situation;Environment;Event;experience;Feedback;Focus Groups;Funding;Future;Geography;Health;health care delivery;health equity;Health Personnel;Health Policy;Healthcare;healthcare community;Homeless persons;Homelessness;Housing;improved;Individual;innovation;instrument;Intervention;Interview;large scale data;Latinx;Learning;Link;Lived experience;Measures;Mental association;Mental disorders;Mental Health;Mental Health Services;Methods;Modeling;Morbidity - disease rate;mortality;Natural experiment;Nature;Outcome;Outpatients;pandemic disease;Pathway interactions;Patients;Persons;Phase;Policies;policy implication;Policy Maker;Population;post-pandemic;Procedures;Process;programs;prospective;Provider;Public Health;Qualitative Research;Race;Research;response;Retrospective Studies;Risk;service providers;Sexual and Gender Minorities;Shelter facility;Site;Strategic Planning;supported housing;System;Underserved Population;Visit;Vulnerable Populations;Well in self

PROJECT_TITLE: Examining Non-Congregate Shelter Effects on Mental Health Crises through Community Health Partnerships in Connecticut

STUDY_SECTION_NAME: Special Emphasis Panel[ZNR1 REV-N (07)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE The biogenesis of the immunogenic SARS-CoV-2 spike (S) protein involves its trafficking between endoplasmic reticulum, Golgi network, and plasma membrane (PM), which provide the enzymatic machinery for post- translational modifications, remodeling, and maturation including of N-glycans that modulate S immunogenicity. Atomic-level insights into how S trafficking modulates N-glycan maturation and subsequent interactions with the immune system will substantially enhance our understanding of COVID-19 infection mechanism, genetic vaccine design, and provide a platform to understand the fundamental principles of viral glycoprotein biogenesis. The investigations proposed in this grant will employ structural, computational, and biophysical tools to generate atomic level details underlying the modulation of S conformations and epitope exposure by N-glycans, thus providing new approaches to vaccine design against existing and emerging coronaviruses.

PI_NAMEs: HASAN, SYED SAIF  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;ACE2;acquired immunity;age difference;age group;Antibodies;Antibody Response;Antigens;Applications Grants;Architecture;Biogenesis;Biological Assay;biophysical tools;Brain;Cell membrane;Cells;comparative;computerized tools;conformational conversion;Coronavirus;Coronavirus Infections;Coronavirus spike protein;coronavirus vaccine;COVID-19 pandemic;COVID-19 vaccine;Cryoelectron Microscopy;Data;design;Detergents;Development;Endoplasmic Reticulum;Enzymes;Epitopes;Ethnic Origin;Flavivirus;Future;Generations;genetic vaccine;global health;Glycoproteins;glycosylation;Golgi Apparatus;Grant;Heart;high reward;high risk;HIV;Homeostasis;Immune;Immune response;Immune system;Immunity;immunogenic;immunogenicity;Immunology;improved;Influenza;influenzavirus;innovation;insight;Interferometry;Investigation;Kidney;Length;Libraries;Link;Liver;Lung;Mammalian Cell;Mannose;Mass Spectrum Analysis;Mediating;Membrane;Methodology;Molecular Conformation;molecular dynamics;Monoclonal Antibodies;novel;novel coronavirus;novel strategies;Organelles;Outcome;particle;Pathway interactions;Play;Polysaccharides;Population;Population Heterogeneity;Post-Translational Protein Processing;precision genetics;Proteins;Race;receptor;receptor binding;reconstruction;Recycling;Research;Resolution;Role;Sampling;SARS-CoV-2 infection;SARS-CoV-2 spike protein;scaffold;Secretory Cell;Site;Stress;Structure;Subunit Vaccines;Surface;Tail;Time;Tissues;trafficking;transmission process;Vaccine Design;vaccine immunogenicity;vaccine response;Vaccines;Viral;Virion;Virus

PROJECT_TITLE: Structural investigations of coronavirus spike protein

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Cerebellar nuclei (CbN), the main output from the cerebellum, play the key role in the regulation of movement, and have well-demonstrated pathology in patients suffering from spinocerebellar ataxia type 1 (SCA1). Currently, very little is known about the disease pathogenesis in CbN in any of the spinocerebellar ataxias (SCAs), including SCA1. The research described in this proposal will fill these gaps in our knowledge by determining how function of CbN is altered throughout SCA1 progression, how changes in CbN contribute to SCA1-like motor deficits, and how mutant ATXN1 (mATXN1) impacts CbN in SCA1.

PI_NAMEs: CVETANOVIC, MARIJA  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Ataxia;ataxin-1;Behavior;CAG repeat;cell type;Cells;Cerebellar Cortex;Cerebellar Diseases;Cerebellar Nuclei;Cerebellum;confocal imaging;Data;Disease;Disease Progression;Enterobacteria phage P1 Cre recombinase;Equilibrium;Excitatory Synapse;Functional disorder;Future;Gait;Gene Expression;Genes;genetic approach;Goals;Image Analysis;Immunofluorescence Immunologic;improved;Inherited;Knock-in Mouse;Knowledge;Molecular;Motor;motor behavior;motor deficit;mouse genetics;mouse model;Movement;Mus;mutant;Neurodegenerative Disorders;Neurons;novel;Nucleus fastigii;Output;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Performance;Phenotype;Play;Purkinje Cells;Regulation;Research;Role;Signal Pathway;Spinocerebellar Ataxias;Synapses;targeted treatment;Testing;Type 1 Spinocerebellar Ataxia;virus genetics

PROJECT_TITLE: Cerebellar Nuclei Dysfunction in Spinocerebellar Ataxia Type 1

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Poor medication adherence in heart failure can lead to poor health, but many clinicians are unable to determine who would benefit from interventions to address adherence. We will build machine learning models to identify patients at risk of not taking their medicines using an approach that minimizes potential biases. Electronic health record data will be used in these models, allowing them to be incorporated into interventions to improve medication adherence and reduce the disease burden of heart failure.

PI_NAMEs: ADHIKARI, SAMRACHANA ;BLECKER, SAUL B. (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Adherence;algorithm development;Algorithms;Big Data;burden of illness;Calibration;Cessation of life;Clinical;clinical care;Clinical Data;Communities;Complex;contextual factors;Data;Data Element;Development;Economic Factors;electronic health data;Electronic Health Record;Ensure;evidence base;flexibility;Goals;Health;health data;Health system;Healthcare Systems;Heart failure;high risk;hospital readmission;hospitalization rates;improved;improved outcome;Individual;innovation;Intervention;Link;Location;Machine Learning;machine learning algorithm;machine learning model;Malignant Neoplasms;Measurement;medication compliance;medication nonadherence;Medicine;model generalizability;Modeling;mortality;Neighborhoods;novel;Outcome;patient population;patient subsets;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;Pharmacy facility;point of care;population based;Population Heterogeneity;prediction algorithm;predictive modeling;predictive tools;Process;Provider;racial population;Risk;Risk Factors;social determinants;Social Environment;social factors;social health determinants;socioeconomics;supervised learning;System;Techniques;Time;tool;Update;Urban Health;Validation;Work

PROJECT_TITLE: Generalizable prediction of medication adherence in heart failure

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Infectious Diseases;Microbiome;Pediatric;Rheumatoid Arthritis

ORG_DEPT: PEDIATRICS

PHR: PUBLIC HEALTH RELEVANCE Children with juvenile idiopathic arthritis (JIA) experience periods of disease flare, and it has been theorized that infections trigger flares, but the theory has not been well-studied. This study aims to describe the frequency and character of acute upper respiratory infections in young children with JIA, evaluate the effects of infection on the nasopharyngeal microbiome in these children, and assess the relationship between viral infections and JIA disease activity. The study may identify novel pathways of pathogenesis in JIA, which may lead to new treatments and prevention strategies.

PI_NAMEs: CORRELL, COLLEEN KELLY MARIE (contact);THIELEN, BETH KRISTINE

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: 16S ribosomal RNA sequencing;7 year old;Acute;Adult;Affect;Antibiotics;Antibodies;Arthritis;arthropathies;Autoantibodies;Autoimmune Diseases;Belief;beta diversity;Biological;Characteristics;Child;Childhood;Chronic;Chronic Childhood Arthritis;Clinical;cohort;comparison control;Data;Detection;Development;Disease;disease mechanisms study;disorder control;dysbiosis;Electronics;Enrollment;Epidemiology;Etiology;experience;Family;Flare;Frequencies;Frustration;Functional disorder;Genetic;genetic risk factor;high risk;Home;Hospitalization;Immune;Immune response;improved;Incidence;Infant;Infection;Inflammatory Arthritis;joint inflammation;Knowledge;Link;Mediating;Methods;microbiome;microbiota;microbiota composition;Monitor;Mucous Membrane;nasal microbiota;nasal swab;Nasopharynx;next generation sequencing;Nose;novel;novel therapeutic intervention;Organism;Outcome;Pathogenesis;pathogenic autoantibodies;pathogenic virus;Pathway interactions;Patient Self-Report;Patients;pediatric rheumatic diseases;peer;Periodontal Diseases;Periodontitis;Pharmaceutical Preparations;pre-clinical;Predisposition;Prevention strategy;Probability;prognostication;Prospective Studies;public health relevance;Publishing;respiratory;respiratory microbiome;respiratory microbiota;Rheumatoid Arthritis;Rheumatoid Factor;rheumatologist;Risk;Role;Sampling;Seasons;Severities;Siblings;Surveys;Symptoms;Techniques;Testing;theories;United States;Upper Respiratory Infections;Viral;viral detection;Viral Respiratory Tract Infection;virome;Virus Diseases

PROJECT_TITLE: Longitudinal characterization of the role of the mucosal virome and microbiome in juvenile idiopathic arthritis flares

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project Narrative Restoration of function after tendon injury is elusive due to the formation of disorganized scar tissue rather than the hierarchical, anisotropic tissue that enables force transmission. This research leverages anisotropic hydrogels as an instructive scaffolds for tenocytes, designing a pro-regenerative environment that recapitulates the structural organization of native tendon.

PI_NAMEs: BENOIT, DANIELLE S. (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: 3-Dimensional;Address;Anisotropy;arm;Biochemical;Biocompatible Materials;Biological;Biophysics;Cell Separation;Cells;Characteristics;Cicatrix;Clinical;Collagen Type I;Collagen Type III;Complex;crosslink;Cues;Data;Deposition;design;Electrospinning;Encapsulated;Engineering;Environment;Equilibrium;ethylene glycol;Exhibits;experimental study;Extracellular Matrix;fabrication;Fiber;Fibrosis;functional restoration;Gene Expression;Gene Expression Profile;Genes;Genetic Markers;Human;Hydrogels;In Vitro;in vivo;Injury;injury and repair;insight;Knowledge;Libraries;Maleimides;Matrix Metalloproteinases;Measures;mechanical properties;Mediating;Microscopy;Modulus;Monitor;Muscle;Musculoskeletal;nanocrystal;novel strategies;Outcome;Peptides;Persons;Phenotype;polymerization;Polymers;programs;Property;Reaction;regenerative;regenerative healing;repaired;Research;restoration;RNA;Role;Sampling;scaffold;scleraxis;screening;Structure;Sulfhydryl Compounds;Techniques;Tendon Injuries;Tendon structure;Testing;three dimensional cell culture;Tissue Engineering;Tissue-Specific Gene Expression;Tissues;transcriptome sequencing;Translating;Translations;transmission process;Up-Regulation;Work;X ray diffraction analysis

PROJECT_TITLE: Recapitulating the native tendon microenvironment through design of degradable, anisotropic engineered extracellular matrices

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Asthma;Biodefense and Related Countermeasures;Biotechnology;Cystic Fibrosis;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Rare Diseases

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: PROJECT NARRATIVE Asthma is a chronic lung disease affecting millions worldwide. We currently have a limited understanding of how the changes to mucus observed in disease contribute to its function. The proposed research aims to provide a new, highly valuable means to understand the impact of disease-associated changes in mucus composition to lung airway dysfunction in asthma and other related muco-obstructive lung diseases.

PI_NAMEs: DUNCAN, GREGG  (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Address;Affect;Affinity;airway epithelium;airway hyperresponsiveness;airway obstruction;Allergens;Aspergillus oryzae;Asthma;asthma exacerbation;asthmatic airway;Binding;Biochemical;Biological Models;Biological Process;biophysical properties;Biophysics;Cell Culture Techniques;Chronic lung disease;clinically relevant;Coughing;CRISPR/Cas technology;Data;defined contribution;delivery vehicle;Development;Disease;Elasticity;Engineering;Extrinsic asthma;Functional disorder;Gel;Gene Delivery;Genes;Genetic Engineering;Goals;Health;Human;Human Engineering;Immobilization;Impairment;improved;in vivo evaluation;Individual;Infection;Influenza A virus;influenzavirus;innovation;insight;Interleukin-13;Knowledge;Left;Life;Lung;Measurement;Measures;Mediating;Modeling;Molecular Biology;mouse model;MUC5AC gene;MUC5B gene;Mucins;Mucociliary Clearance;Mucous body substance;mucus clearance;mucus-associated lung diseases;Mus;new therapeutic target;novel;overexpression;particle;pathogen;Penetration;Predisposition;prevent;Property;Publishing;pulmonary function;Research;respiratory virus;Rheology;Role;Severities;Severity of illness;siRNA delivery;Small Interfering RNA;Specific qualifier value;Structure;Structure of parenchyma of lung;Surface;Symptoms;System;targeted treatment;Techniques;Testing;Tetracyclines;Therapeutic;Thick;tissue culture;tool;translational impact;translational potential;Viral;Viral Respiratory Tract Infection;Virus;Virus Diseases;viscoelasticity;Viscosity;Work

PROJECT_TITLE: Understanding alterations to mucus composition and function in asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric;Pregnancy;Prevention

ORG_CITY: PORTLAND

ORG_DEPT: PSYCHIATRY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: PROJECT NARRATIVE Child developmental and learning problems like ADHD, place heavy, often lifelong burdens on families, as well as on the nation's educational, health care, and justice systems. Early identification of risk and cause of ADHD would enable solutions to restore full child health and prevent onset of ADHD before problems become entrenched. This study will test key possibilities for early life prediction in areas that could be reversible with low-risk intervention.

PI_NAMEs: NIGG, JOEL T;SULLIVAN, ELINOR L. (contact)

PROGRAM_OFFICER_NAME: ZEHR, JULIA L

PROJECT_TERMS: 3 year old;3-Dimensional;5 year old;Affect;Affective;Age;Age Months;Aggressive behavior;Algorithms;Anger;Area;Attention deficit hyperactivity disorder;Behavioral;behavioral outcome;Biological;Biological Markers;Birth;Brain;Breast Feeding;caregiving;Child;Child Health;Circulation;Clinical;clinical application;clinical candidate;clinical risk;Clinical Trials;Cognition;cohort;cost;Data;Depressed mood;Development;Developmental Process;early childhood;Early Diagnosis;Early identification;Early Intervention;Education;Electroencephalography;emotion dysregulation;emotion regulation;Emotional;Environmental Risk Factor;executive function;experimental study;family burden;fetal;Fetal Development;follow-up;Formulation;Fright;Functional disorder;Future;Genetic;Goals;Hand;Healthcare;Impairment;Impulsivity;inattention;indexing;Individual;Infant;Inflammation;Inflammatory;Intercept;interest;Intervention;Intervention Trial;Justice;Kynurenine;Learning;Life;Literature;Magnetic Resonance Imaging;Measurable;Measures;Mediating;Mental Health;Modeling;negative affect;neural;neurodevelopment;Nursery Schools;offspring;Outcome;Parents;Pathway interactions;Phenotype;Physiological;postnatal;Pregnancy;Pregnancy Trimesters;prenatal;Preschool Child;prevent;Program Development;prospective;Psychopathology;Regulation;Risk;Risk Factors;Risk Marker;risk prediction;Role;School-Age Population;Schools;Second Pregnancy Trimester;Serotonin;Shapes;Signal Transduction;Socialization;sound;Symptoms;System;systemic inflammatory response;teacher;Testing;Third Pregnancy Trimester;Time;Toddler;Tryptophan;Up-Regulation;Weather;Woman;Work

PROJECT_TITLE: Developmental origins and early detection of ADHD and dysregulatory psychopathology

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

PHR: The identification of molecular and cellular mechanisms involved in primate cortical development and evolution is essential if we are to understand the origins of, and devise prevention and/or treatments for, genetic and environmentally caused cortical abnormalities in humans. Thus, the expected set of unique data are not only of theoretical significance, but also of considerable clinical importance as they may be relevant to disorders of our highest cognitive functions as well as our response to drugs of therapy and abuse.

PI_NAMEs: RAKIC, PASKO  (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: 3-Dimensional;Area;Bioinformatics;Biological;Breeding;Cells;Cerebral cortex;Clinical;Cluster Analysis;Cognition Disorders;cognitive capacity;cognitive function;comparative;Consumption;cost;Data;Development;Disease;Drug abuse;Embryo;Environment;Event;Evolution;Exposure to;Fibroblasts;Gene Cluster;Gene Expression;gene network;Genes;Genetic;Genetic Determinism;Goals;Grant;Growth;Human;human induced pluripotent stem cells;Humanities;Image;in utero;induced pluripotent stem cell;innovation;insight;Light;Macaca;Mammals;Methodology;Methods;Molecular;Monkeys;Mus;Nature;nerve stem cell;Neurons;Neuropil;neuropsychiatric disorder;nonhuman primate;Pathogenesis;Pathway Analysis;Pattern;Pharmacotherapy;Predisposition;Prefrontal Cortex;prenatal exposure;Prevention;Primates;Process;Regulatory Element;Research;Resolution;response;Rodent;single cell mRNA sequencing;Skin;stem cells;Time;transcriptome;white matter

PROJECT_TITLE: Origin of Cortical Species-specific Distinctions

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative Profiling the spatial proximity of genes and their regulatory elements is one of the critical steps towards developing a fundamental understanding of regulatory processes as well as defining nuclear disorders. Microscopy-based methods have the potential to be applied in research and clinical settings to directly identify healthy and abnormal DNA-DNA contact patterns at the single-cell level, but their robustness and utility are presently limited due to the lack of strategies that simultaneously enable multiplexing (i.e. identifying multiple genomic targets within the same sample), high-throughput (i.e. fast image acquisition), and high-specific target labeling (i.e. low false positives). This project focuses on developing novel DNA-based imaging probes and new experimental approaches to address existing challenges of imaging-based detection of DNA-DNA contacts at the single-cell level.

PI_NAMEs: JEONG, JIYOUN  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Biology;cell behavior;Cell Nucleus;Cell Physiology;Cells;Cellular Assay;chromosome conformation capture;Chromosomes;Clinical;Color;Communication;Communities;Complement;density;Detection;detection assay;Diagnostic;Disease;Distal;DNA;DNA Sequence;Engineering;Ensure;Environment;Exhibits;experience;experimental study;Face;Fluorescent in Situ Hybridization;Frequencies;Gene Expression;Genes;genetic element;Genome;genome-wide;Genomic DNA;genomic locus;Genomics;Goals;Heterogeneity;Image;imaging detection;imaging probe;In Situ;In Situ Hybridization;Individual;interest;Label;Maps;Measurement;Measures;Mentorship;Methodology;Methods;Microscopy;Molecular;multiplexed imaging;nanoscale;Nature;new technology;novel;novel diagnostics;novel strategies;Nuclear;Organelles;Output;Pattern;Phenotype;Positioning Attribute;Process;Proteins;Reaction;Regulatory Element;Research;Resolution;Resources;RNA;Sampling;Signal Transduction;spatiotemporal;Structure;technology development;tool;Translations;Universities;Validation;Variant;Visualization;Yin

PROJECT_TITLE: Novel strategies for high-specific multiplexed imaging of genomic interactions by signal amplification


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Cancer;Hematology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases;Sickle Cell Disease

ORG_CITY: FAYETTEVILLE

ORG_NAME: CELLIA SCIENCE, INC.

PHR: Project Narrative Bone marrow aspirates are critical to the diagnosis, staging, and monitoring of hematologic conditions and cancers (e.g., leukemia, aplastic anemia, sickle cell disease, and metastasis of solid tumors), but 8-50% of aspirations are unsuccessful due to operator technique, hemodilution, or underlying pathology. Cellia Science will enable improved quality and reliability of bone marrow aspiration procedures by developing an automated point-of-care instrument for assessment of sample adequacy. Cellia is applying for TABA funding to support the development of a strategic plan for improving the protection of our adequacy assessment technology and the drafting of a filing consistent with the strategic plan.

PI_NAMEs: ROBLES, FRANCISCO E (contact)

PROGRAM_OFFICER_NAME: ASHMONT, KARI RICH

PROJECT_TERMS: Address;Adopted;Adoption;Aplastic Anemia;Artificial Intelligence;aspirate;Assessment tool;attenuation;bone;bone imaging;Bone Marrow Aspiration;Businesses;cellular imaging;Characteristics;Classification;Collection;Computer software;Data;Detection;Development;Devices;Diagnosis;Diagnostic;Ensure;Eye;Family;feature extraction;Feedback;Foundations;Funding;Future;Giemsa stain;Goals;Grant;Hematology;Hemodilution;Image;improved;innovation;instrument;Intellectual Property;invention;Label;Left;Legal patent;leukemia;Light;Machine Learning;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of thyroid;Malignant Neoplasms;Manuals;Microscopy;Monitor;Neoplasm Metastasis;Parents;Pathology;Patient-Focused Outcomes;Patients;Phase;Play;point of care;Procedures;Process;Protocols documentation;prototype;Quality of Care;Renal Carcinoma;Role;Sampling;Science;screening;Secure;Sensitivity and Specificity;Sickle Cell Anemia;Slide;Small Business Technology Transfer Research;Solid Neoplasm;Specific qualifier value;Staging;Strategic Planning;success;Techniques;Technology;Technology Assessment;Time;time use;Training;ultraviolet;Visual;Work

PROJECT_TITLE: Deep-UV Microscopy for Real-Time Adequacy Analysis of Bone Marrow Aspirates


ORG_CITY: BOSTON

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative Nucleic acids exhibit inherently unfavorable biopharmaceutical properties due to specific and non-specific interactions with proteins (enzyme stability, immunostimulation, coagulopathy, etc.), which hamper their development as therapeutic agents. Herein, we will investigate a novel mechanism for nucleic acid delivery based upon entropic protection (termed pacDNA), which facilitates duplex formation but disfavors protein binding (generally the first step leading to undesirable non-hybridization side effects). We will investigate and understand the molecular parameters that give rise to the unique properties of the pacDNA and probe its in vivo characteristics in mouse for gene regulation.

PI_NAMEs: ZHANG, KE  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: adaptive immunity;Binding;Binding Proteins;Biological Products;Blood Coagulation Disorders;Characteristics;combinatorial;density;Deposition;Development;Dose;Drug Kinetics;Enzyme Stability;Exhibits;Face;Funding;Gene Expression Regulation;Heart;immune activation;Immune system;Immunologic Stimulation;improved;in vivo;Investigation;learning materials;Libraries;Molecular;monomer;Mus;novel;novel strategies;nuclease;nucleic acid delivery;Nucleic Acids;oligonucleotide delivery;Oligonucleotides;Organ;pharmacologic;Plasma Enhancement;Polymers;preservation;Property;Proteins;research clinical testing;side effect;Skeletal Muscle;Skin;Structure;System;Technology;Therapeutic Agents;Tissues;Vertebral column

PROJECT_TITLE: Making Oligonucleotides Better Biopharmaceuticals by Steric Protection

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative Even young infants use race to categorize people, yet it is unclear how these perceptual tendencies translate to later social prejudice and stereotypes. The current project aims to examine the precursors of social biases across infancy to childhood by investigating infants’ cognitive inferences about racial groups and stranger fear toward people from different races. This work will elucidate the developmental trajectory of racial biases and how early social experience with racial diversity shapes infants’ emerging understanding of race.

PI_NAMEs: HWANG, HYESUNG GRACE (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 6 year old;7 year old;Age;age difference;Age Months;Attention;Award;Behavior;Behavioral;Categories;Censuses;Child;Childhood;Classification;Cognitive;Conceptions;Data;Data Set;demographics;Development;early childhood;Environment;expectation;experience;experimental study;Exposure to;Face;Face Processing;Friendships;Fright;Future;Human;improved;Individual;infancy;Infant;Infant Behavior;Knowledge;Language;Lead;Learning;longitudinal dataset;Mentors;Motivation;Nature;Neighborhoods;neural;neural correlate;neuromechanism;Persons;Phase;power analysis;preference;Prejudice;Process;Race;racial bias;racial diversity;racial population;racial prejudice;Randomized;Research;Research Personnel;Research Technics;response;Sampling;Shapes;skills;social;Social Behavior;social bias;social group;Social Interaction;Social Network;Speech;Stereotyping;Techniques;Testing;Time;Training;Translating;Work

PROJECT_TITLE: The malleability of social group understanding in infancy and early childhood

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cannabinoid Research;Chronic Pain;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Neurosciences;Pain Research;Precision Medicine;Social Determinants of Health;Therapeutic Cannabinoid Research

ORG_CITY: GAINESVILLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Among older adults, about two-thirds of medical marijuana users indicate chronic pain as the major reason for the treatment. In this study, we will analyze how genetic, sociodemographic, and psychological/behavioral factors are associated with differing responses to medical marijuana. Findings will provide a foundation for understanding the complex array of factors contributing to the varying responses to medical marijuana and informing and monitoring patient care through a personalized medicine approach.

PI_NAMEs: MARINI, SIMONE  (contact);SIBILLE, KIMBERLY THERESA;WANG, YAN

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Adult;Age Years;allostatic load;alternative treatment;Anxiety;Area;Artificial Intelligence;Behavioral;behavioral response;Benefits and Risks;Biological Assay;Biological Factors;Biological Markers;Blood;Blood specimen;Blood Tests;Brain;chronic musculoskeletal pain;chronic pain;chronic pain management;Clinical;clinically relevant;cohort;Cohort Studies;comorbidity;Complex;Data;Disparate;Dose;drug metabolism;Eicosanoids;endogenous cannabinoid system;expectation;experience;Foundations;Funding;Gene Expression;Gene Expression Profiling;gene interaction;Genes;Genetic;Genomics;Goals;hands-on learning;Health;Health Status;Heterogeneity;improved;Individual;Individual Differences;individual variation;Inflammation;Interdisciplinary Study;Legal;Link;low socioeconomic status;Machine Learning;male;Marijuana;marijuana use;marijuana user;Measures;Medical Marijuana;Mental Depression;Meta-Analysis;Metabolic Pathway;Morbidity - disease rate;mortality;multilevel analysis;older adult;Outcome;Outcome Measure;Pain;pain outcome;Participant;Pathology;Pathway interactions;Patient Care;Patient Monitoring;patient subsets;Patients;peer;personalized medicine;Physiological;Polypharmacy;Population;precision medicine;predicting response;Predictive Factor;predictive modeling;Prevalence;Prospective, cohort study;psychologic;reduce symptoms;Regimen;Reporting;Research;response;Safety;Severities;sociodemographics;Socioeconomic Status;Stress;Surveys;System;Treatment Protocols;Vulnerable Populations;whole health;Woman

PROJECT_TITLE: Medical Marijuana and chronic musculoskeletal pain in older adults: a multi-level, precision medicine analysis

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Rare Diseases

ORG_CITY: Chicago

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative This study builds on a larger parent R01 project to study how motor-speech characteristics contribute to the social communication differences that characterize autism and have been linked to a specific autism candidate gene, FMR1. The project focuses on carriers of the FMR1 premutation, to understand the different skills that contribute to social communication impairments in autism, and how they may be linked to neurobiological and molecular genetic factors. Outcomes of the study may have significant clinical-translational implications, benefiting both the autism and FMR1 communities and paving the way for more effective interventions and precision medicine approaches.

PI_NAMEs: LOSH, MOLLY C (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Affect;Articulation;Auditory;auditory feedback;autism spectrum disorder;autism symptoms;Behavioral;behavioral outcome;Biological;biological research;brain behavior;Candidate Disease Gene;case control;Characteristics;Child;Clinical;clinical application;clinical practice;Clinical Research;clinical translation;cohort;Communities;Companions;Complex;Data;Databases;diagnostic biomarker;Dimensions;effective intervention;Equation;Family;First Degree Relative;FMR1 gene;FMR1 Premutation;Fragile X Premutation;Fragile X Syndrome;Funding;gaze;Genes;Genetic;Genetic Markers;Genetic Variation;Goals;Heritability;Impairment;indexing;Individual;individuals with autism spectrum disorder;insight;Intervention;Intervention Studies;Language;life span;Link;Measures;Methodology;Modeling;Molecular Genetics;Mothers;Motor;Mutation;mutation carrier;Narration;National Institute of Mental Health;neural;Neural Pathways;Neurobiology;neurophysiology;Outcome Study;Parents;Participant;Pathway interactions;Periodicity;Phenotype;precision medicine;Reporting;Research;Research Design;risk variant;Sampling;segregation;skills;social;social communication;social communication impairment;Social Environment;Speech;speech processing;stem;Subgroup;symptomatology;Symptoms;tool;trait;Translations;Variant;Work

PROJECT_TITLE: Mechanistic underpinnings of pragmatics in ASD: Insights from FMR1-mutation conditions

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: MOSCOW

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PI_NAMEs: BOHACH, CAROLYN HOVDE (contact)

PROGRAM_OFFICER_NAME: ARORA, KRISHAN


ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE This proposal is focused on the development and testing of potent, receptor selective, and safe peptide multi- agonists for child and adolescent obesity treatment by both stimulating the melanocortin pathway and select gut peptide (GLP-1/PYY) pathways to both increase energy expenditure and suppress energy intake. This project will focus on obtaining proof-of-concept data in rats, for future translational advancement as next generation weight-loss agents for children.

PI_NAMEs: DOYLE, ROBERT P;ROTH, CHRISTIAN LUDWIG (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Adolescent;Adolescent obesity;Adult;Adverse effects;Agonist;analog;Anti-Obesity Agents;Appetite Depressants;Area;ART protein;Binding;Blood Glucose;blood glucose regulation;Body Composition;Body Weight;Body Weight decreased;Brain;Child;Combined Modality Therapy;comparison control;Cyclic AMP;Data;Development;diet-induced obesity;Dose;Drug Design;Eating;effective therapy;efficacy testing;energy balance;Energy Intake;Energy Metabolism;exenatide;Exhibits;Expenditure;Exposure to;FDA approved;feeding;FOS gene;Future;gastrointestinal;Generations;GLP-I receptor;glucagon-like peptide 1;glucose metabolism;glycemic control;Goals;heart disease risk;High Fat Diet;High Prevalence;Homeostasis;Hormonal;Hunger;Hyperpigmentation;Hypothalamic structure;improved;In Vitro;in vitro Assay;in vivo evaluation;Injections;Injury;Kidney Diseases;Label;Lead;liraglutide;Malaise;Measures;Mediating;Melanocortin 4 Receptor;melanocortin receptor;melanocyte;Metabolic Diseases;monomer;Morbidity - disease rate;mortality;Mus;Mutation;Nausea;Neurons;Neuropeptide Receptor;neuropeptide Y;Neuropeptide Y Receptor;neuropeptide Y2 receptor;Neuropeptides;New Agents;next generation;novel;Nutrient;nutrition;obese patients;Obesity;obesity genetics;obesity in children;obesity treatment;Pathway interactions;patient tolerability;Patients;Penetration;Peptide Library;Peptides;Peripheral;Physiological;Play;Population;prevent;Pro-Opiomelanocortin;protein aminoacid sequence;Publishing;Rattus;receptor;receptor binding;Receptor Gene;Receptor Signaling;Recovery;reduced food intake;Regulation;Research;response;Risk Reduction;Rodent;Rodent Model;Role;Running;Safety;Shrews;side effect;Signal Transduction;Stains;System;targeted treatment;Testing;therapeutic target;Thinness;Tissues;tool;Universities;Visceral;Vomiting;Washington;Weight;Weight-Loss Drugs;Wistar Rats;Work

PROJECT_TITLE: Efficacy of Novel Melanocortin and Gut-peptide Dual Agonists for Childhood Obesity Treatment

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Pediatric;Substance Misuse

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: Project Narrative Nearly 7 million undergraduate college students live in states where recreational cannabis use has been legalized, yet few, if any, interventions have been created to convey accurate information about cannabis products, cannabis marketing, and cannabis risks to young adults in an effort to reduce use and misuse. We have developed an intervention that positively impacts college students' knowledge of cannabis products and laws, efficacy in navigating cannabis products, and risk perceptions. The proposed study will refine and assess the feasibility and acceptability of this technology-based intervention that will increase college students’ awareness of the risks associated with cannabis use while also empowering young adults who choose to use cannabis to do so in an informed manner, which will ultimately help reduce cannabis misuse among U.S. college students.

PI_NAMEs: HUST, STACEY JOLENE;WILLOUGHBY, JESSICA FITTS (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Academic achievement;acceptability and feasibility;Accounting;Adult;Advisory Committees;Age;Alcohols;Awareness;Brain;Cannabis;Cannabis retail;Cognition;college;Complex;Country;Cross-Sectional Studies;Data Sources;design;Development;District of Columbia;Elements;empowerment;Enrollment;experience;Feedback;Focus Groups;Frequencies;gender difference;Goals;Health;Health Educators;health goals;Human;improved;Industry;information gathering;Intervention;intervention delivery;intervention refinement;Interview;Knowledge;Laws;Legal;Letters;Life Style;literacy;Location;Longitudinal Studies;marijuana legalization;marijuana use;marijuana user;Marketing;Methods;Outcome;Participant;Perception;Personality;Policies;Prevention program;programs;Public Health;Randomized, Controlled Trials;Recreation;Reporting;Research;Risk;risk perception;Site;Source;substance misuse;Surveys;technology intervention;Teenagers;Testing;therapy design;Treatment Efficacy;undergraduate student;United States;university student;Washington;young adult

PROJECT_TITLE: Development and Acceptability Testing of a Technology-based Intervention to Reduce College Students' Cannabis Misuse

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


FUNDING_MECHANISM: SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: Cary

ORG_NAME: FOCAL MEDICAL, INC.

ORG_STATE: NC

PHR: Potential alternative to surgical resection in oral cancer treatment.

PI_NAMEs: HAM, STEPHANIE LEMMO (contact)

PROJECT_TERMS: Animal Model;Award;Cancer Patient;cancer therapy;Canis familiaris;Carboplatin;Cessation of life;chemotherapy;Chemotherapy and/or radiation;clinically relevant;Development;Devices;Disease;Dose Limiting;Drug Delivery Systems;Eligibility Determination;Excision;Face;Hydrogels;In Vitro;in vivo;Iontophoresis;Life;malignant mouth neoplasm;Medical;Methods;Modeling;Mouth Neoplasms;novel;Operative Surgical Procedures;Organ;Patients;Probability;Quality of life;Radiation therapy;response;Risk;safety and feasibility;Small Business Innovation Research Grant;success;Testing;Toxic effect;tumor;Tumor Promotion;Unresectable;Work

PROJECT_TITLE: 2024 SBIR CONCEPT CLEARANCE AWARD


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Hematology;Lymphatic Research;Lymphoma;Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: LUNENBURG

PHR: Please contact COR.

PROJECT_TERMS: Address;Award;Brain Neoplasms;Child;Collaborations;design;Detection;detection platform;detector;Development;Diagnosis;Evaluation;Functional Imaging;Funding;Gamma Rays;Germ cell tumor;Glass;Imaging Techniques;Individual;innovation;Lasers;Lymphoma;Malignant Childhood Neoplasm;Medical;Methodology;Monitor;Nephroblastoma;Neuroblastoma;Neurofibromatoses;novel;Pediatric Oncology;Performance;Photons;Positron-Emission Tomography;programs;Radiation Dose Unit;Radiation exposure;rare cancer;Risk;Sarcoma;Small Business Innovation Research Grant;Structure;Surface;Survival Rate;System;Technology;Testing;Work


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases

ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PI_NAMEs: MOFFAT, JENNIFER  (contact)

PROJECT_TERMS: Contracts;Cytomegalovirus;Development;Evaluation;Herpesvirus Type 3;Human;infectious disease model;mouse model;therapeutic development;Xenograft procedure

PROJECT_TITLE: Task A77: Xenograft Mouse Models for Varicella Zoster Virus and Human Cytomegalovirus


NIH_SPENDING_CATS: Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Acetaminophen (APAP) exposures are ubiquitous use during pregnancy and early life during lung development. Alarmingly, clinical data support the hypothesis that the developing lung may be adversely affected by APAP exposure due to the developmental ontogeny of pulmonary CYP2E1 expression. These pre- clinical studies will be the first to interrogate the mechanisms underlying the unique susceptibility of the developing lung to APAP exposure and help determine its safety profile in this understudied population.

PI_NAMEs: WRIGHT, CLYDE JASON (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Acetaminophen;Acute;Adult;Adverse effects;Affect;Alveolar;Analgesics;Attenuated;Biology;Bronchopulmonary Dysplasia;Cell Death;cell type;Cells;Childhood;Clinical;Clinical Data;clinically relevant;CYP2E1 gene;Data;Development;drug action;Enzymes;experimental study;Exposure to;fetal;Fetal Lung;Funding Opportunities;gain of function;genetic approach;Growth;Hepatic;hepatocellular injury;Hepatocyte;Hepatotoxicity;Human Development;Hyperoxia;Imines;immune activation;Immune signaling;Immunology;improved;in utero;in vivo;Injury;Knowledge;Life;Link;Liver;loss of function;Lung;lung development;lung injury;maternal safety;Mediating;medication safety;Metabolic stress;Metabolism;Mitochondria;Mitochondrial DNA;Mus;Myofibroblast;Neonatal;neonatal exposure;Neonatal Intensive Care Units;Neonatal lung;neonatal lung injury;Newborn Infant;novel;opioid exposure;Outcome;Oxidative Stress;para-benzoquinone;Patent Ductus Arteriosus;Pathway interactions;Perception;Perinatal;Perinatal Exposure;pharmacologic;Physiology;Placenta;Population;Positioning Attribute;postnatal;pre-clinical;preclinical development;preclinical study;Predisposition;Pregnancy;pregnant;prenatal;preterm newborn;receptor;Reporting;respiratory morbidity;response;Risk;Safety;Signal Transduction;Slice;Stress;stressor;Structural defect;Structure;Testing;therapeutic target;Toxic effect;Toxin;Xenobiotics

PROJECT_TITLE: Pulmonary implications of perinatal acetaminophen exposure


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The cell employs a degradation system known as the ESCRT (Endosomal Sorting Complexes Required for Transport) machinery to prevent the accumulation of signaling molecules and their receptors. We discovered that mouse models with loss of ESCRT encoding-genes exhibit shorter jaw and clefting of the secondary palate, suggesting that this machinery controls craniofacial development by regulating the cellular levels of specific signaling molecules. Using multiple mouse lines we engineered that lack one of the ESCRT encoding-genes we will identify ESCRT-dependent genetic pathways that are required for normal face and mouth development, enriching the current molecular diagnostics toolkit for craniofacial birth defects.

PI_NAMEs: SELLERI, LICIA  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Affect;Alleles;Branchial arch structure;Cell membrane;Cells;Cephalic;Cleft Palate;Complex;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;craniofacial development;craniofacial structure;Defect;design;Development;Down-Regulation;Dyes;Ear;Elements;Embryo;Embryonic Development;endosome membrane;Endosomes;Engineering;Enzyme-Linked Immunosorbent Assay;Enzymes;Epigenetic Process;Epithelium;Ethylnitrosourea;Exhibits;experimental study;external ear auricle;Face;Feedback;Fibroblast Growth Factor;Genes;Genetic;Head;Heart;Human;In Vitro;Invertebrates;Investigation;Jaw;Limb structure;Link;lipid metabolism;lipidomics;Lipids;lipophilicity;LoxP-flanked allele;Mass Spectrum Analysis;Mediating;Membrane;Mesenchyme;Metabolic Pathway;Metabolism;Modeling;Modification;Molecular Diagnosis;molecular diagnostics;Morphogenesis;mouse model;Mus;Mutagenesis;mutant;Mutant Strains Mice;Mutation;Neural Crest;Neural Crest Cell;novel;Oral cavity;Pathway interactions;pharmacologic;Phenocopy;Phenotype;Polydactyly;Pregnancy;prevent;Proteins;Publishing;receptor;recruit;Regulation;repaired;Reporting;Research;Role;Secondary Palate;Serine;SHH gene;Signal Pathway;Signal Transduction;Signaling Molecule;smoothened signaling pathway;Sonic Hedgehog Pathway;Sorting;Sphingolipids;Stains;Structure;Syndrome;System;Tissues;trafficking;transcription factor;Transferase;Up-Regulation;Work

PROJECT_TITLE: Control of Mammalian Craniofacial Morphogenesis by the ESCRT Machinery

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: LOMA LINDA

ORG_NAME: VA LOMA LINDA HEALTHCARE SYSTEM

PHR: Nearly 350,000 United States Military Servicemembers have been diagnosed with a mild traumatic brain injury (mTBI) since the year 2000. Recent surveys suggest that half or more of Veterans with mTBI will report problems with their vision, but visual deficits are often not detected in this population using standard clinical tests. Failure to diagnose and treat these visual deficits may exacerbate or prolong the everyday difficulties experienced by Veterans with mTBI (e.g., reading, driving, or following a visual presentation), presenting a critical barrier to successful rehabilitation and reintegration. In other acquired visual disorders, changes in color vision are often the earliest sign of vision loss. This study develops a new test of color vision designed to capture subtle differences in the processing of color signals at peripheral and central stages of the visual system. This “mutli- stage” approach is geared toward characterizing the complex profile of visual deficits associated with mTBI and can easily be extended to other domains of visual function such as motion or luminance contrast.

PI_NAMEs: VENEZIA, JONATHAN HENRY (contact)

PROJECT_TERMS: Achievement;Address;Affect;Affective;Age;age group;Aging;Attention;Auditory;Automobile Driving;Blindness;Brain;Chronic;Clinical;Cognitive;Color;color processing;Color Visions;Compensation;Complex;Data;design;Detection;Diabetic Neuropathies;Diagnosis;Diagnostic;Diagnostic tests;diagnostic value;Dimensions;Discrimination;discrimination task;Disease;Elements;Environment;experience;Factor Analysis;Failure;Functional disorder;Goals;Grouping;Hearing problem;Individual;Individual Differences;individual variation;Lead;Life;luminance;mathematical model;Measurable;Measurement;Measures;Mediating;Methods;mild traumatic brain injury;military service;Modeling;Motion;multisensory;Nervous System Trauma;novel;Optic Neuritis;Optics;Pathway interactions;Patient Self-Report;Pattern;Perception;Performance;Peripheral;Play;Population;post 9/11;Property;Reading;receptor;Rehabilitation therapy;Reporting;Research;Retina;Role;segregation;Sensory;sensory mechanism;service member;Signal Transduction;Source;Statistical Models;Stimulus;Structure;Surveys;Testing;Texture;Time;Trauma;United States;Variant;Veterans;Vision;Vision Disorders;Vision Tests;Visual;Visual Acuity;Visual attention;Visual Pathways;visual processing;Visual System;Work

PROJECT_TITLE: Individual Differences in Color Vision Assessed with Chromatic Textures

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: NUTRITION

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Representing almost 12% of all cases worldwide, female breast cancer was the most commonly diagnosed cancer in 2020 and accounted for 1 in 6 cancer-related death among women, indicating an increasingly urgent need for novel therapeutic strategies targeting both disease onset and tumor progression. 15% of women globally, and more than forty percent of women in the US are obese, and while it is known that obesity increases a woman’s risk of breast cancer, the potential for targetable mechanisms mediating this relationship remains unclear. The findings from this proposal will inform alternative approaches for triple negative breast cancer patients- as first-line interventions themselves, or as additions to improve efficacy of traditional treatment regimens.

PI_NAMEs: DEVERICKS, EMILY  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Aftercare;aggressive breast cancer;anti-cancer research;antioxidant enzyme;antiport;breast cancer metastasis;Breast Cancer Patient;breast cancer progression;Breast Cancer Risk Factor;Cancer and Nutrition;cancer diagnosis;Cancer Etiology;Cancer Patient;cancer subtypes;cancer type;career;Cause of Death;Cell Death;Cell Death Induction;Cell Proliferation;Cells;Cessation of life;Characteristics;Cystine;Dependence;Diet;diet-induced obesity;Dietary Intervention;Disease Progression;Doctor of Philosophy;Educational Curriculum;Energy-Generating Resources;Environment;Enzymes;erastin;Exposure to;extracellular;Fatty acid glycerol esters;fatty acid metabolism;Fatty Acids;Fatty Change;Fellowship;Female Breast Carcinoma;Foundations;Funding;Future;Genetic;Genetic Transcription;Glutamate Metabolism Pathway;Glutamate Transporter;Glutamates;Glutamine;Glutathione;glutathione peroxidase;High Fat Diet;High-Throughput RNA Sequencing;Imidazole;improved;improved outcome;In Vitro;in vivo;in vivo Model;inhibitor;Injections;Intercellular Fluid;Intervention;Investigation;Iron;Ketones;Link;lipid metabolism;Lipid Peroxidation;lipidomics;Lipids;Literature;Lung;lung colonization;lung metastatic;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Measurement;Mediating;Mediator;Membrane;Mentors;Metabolic;migration;Modeling;Molecular;Monitor;mortality;mouse model;Mus;Neoplasm Metastasis;novel therapeutic intervention;Nutritional Biochemistry;Nutritional Science;Obese Mice;obese patients;Obesity;Onset of illness;Oxaloacetates;pharmacologic;Phospholipids;Plasma;pre-clinical;Preparation;Primary Neoplasm;Proliferating;Pyruvate;Pyruvate Carboxylase;response;Risk Factors;Role;Scientist;Serum;Severities;small hairpin RNA;Tail;Testing;Therapeutic;therapeutic target;Training;Transcriptional Regulation;transcriptome sequencing;translational cancer research;transplant model;Treatment Protocols;Triglycerides;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Markers;tumor metabolism;tumor microenvironment;tumor progression;Tumor Promotion;Up-Regulation;Veins;Woman;Women's mortality;Work

PROJECT_TITLE: Evaluating the impact of obesity associated fatty acid metabolic dysregulation on breast cancer sensitivity to ferroptosis


ORG_CITY: DALLAS

ORG_NAME: VA NORTH TEXAS HEALTH CARE SYSTEM

ORG_STATE: TX

PHR: Kidney failure has been recognized as one of the most costly chronic conditions among United States Veterans. Approximately 13,000 Veterans develop kidney failure each year, and most require hemodialysis initiation. Hemodialysis patients suffer significantly increased risk of death and hospitalizations, and excessive body fluid is a major cause of this. While empiric aggressive fluid removal during dialysis is one approach to limit fluid overload, this can cause dangerous decreases in blood pressure during dialysis that independently contribute to the high death rate. In this study, I aim to test a new strategy that prescribes fluid removal based on a patient’s recent blood pressure patterns during dialysis. This clinical trial will compare my strategy to standard care and assess the outcomes of overall blood pressure change between dialysis treatments in addition to the number of times the blood pressure becomes dangerously low during dialysis. Another aim is to determine how differences in the structure and function of the heart influence blood pressure during dialysis.

PI_NAMEs: VAN BUREN, PETER NOEL (contact)

PROJECT_TERMS: Achievement;Acute;Address;Adverse event;Affect;Algorithms;Assessment tool;Blood Pressure;blood pressure reduction;Blood Vessels;Body Fluids;Body Weight;Cardiac;Cardiac Output;Cardiovascular Diseases;Cardiovascular system;Caring;Chest;Chronic;Clinical;clinical care;Clinical Management;clinical practice;Clinical Trials;comparison group;cost;Cross-Sectional Studies;Dangerousness;Data;Death Rate;design;Dialysis procedure;Echocardiography;Eligibility Determination;End stage renal failure;Enrollment;Equilibrium;Excision;Exclusion Criteria;Expenditure;extracellular;Fluid overload;follow-up;Frequencies;Functional disorder;Future;General Population;Goals;Guidelines;heart function;Hemodialysis;hemodynamics;high risk;Hospitalization;Hour;hypertensive;Hypotension;Impairment;improved;indexing;individual patient;innovation;Intervention;intervention effect;Kidney Diseases;Kidney Failure;Left Ventricular Ejection Fraction;Left Ventricular Mass;Linear Models;Liquid substance;Maintenance;Measurement;Measures;Methods;Monitor;Morbidity - disease rate;mortality;mortality risk;Multicenter Trials;Myocardial dysfunction;novel;Outcome;Outcome Assessment;patient population;Patients;Pattern;Peripheral Resistance;personalized approach;Phenotype;Physiology;Population;Practice Management;Prevalence;primary outcome;prospective;Randomized Controlled Clinical Trials;randomized trial;recruit;Research;Residual state;Risk;Risk Factors;routine practice;Safety;Spectrum Analysis;standard care;Structure;Symptoms;Testing;tool;Ultrafiltration;United States;Update;Veterans

PROJECT_TITLE: Using Intradialytic Blood Pressure Slopes to Guide Ultrafiltration in Hemodialysis Patients


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE The strongest genetic risk factor for developing late-onset Alzheimer’s disease is carrying the E4 allele of APOE, which codes for the protein apoliprotein E (APOE). We are testing the function of APOE in the fat metabolism of brain cells called astrocytes and microglia. These studies will lead to increased understanding of the mechanism by which APOE4 causes increased risk of neurodegeneration and could lead to the identification of new drug targets.

PI_NAMEs: COHEN, SARAH  (contact);JOHNSON, LANCE ALLEN

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Affect;Age;aging brain;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloidosis;Apolipoprotein E;apolipoprotein E-4;Area;Astrocytes;Brain;brain cell;Brain region;Cause of Death;Cell Death;cell type;Cellular biology;Central Nervous System;Code;Communities;cytokine;Cytoplasm;Data;Data Set;Databases;Dementia;Dependence;Deposition;disability;Drug Targeting;Educational workshop;Effector Cell;Endoplasmic Reticulum;Fluorescence-Activated Cell Sorting;Future;genetic risk factor;Genotype;Glycolysis;Homeostasis;human old age (65+);Image;Immune;in vivo;Inflammation;Inflammatory;insight;Investigation;Knockout Mice;Knowledge;laboratory experience;Late Onset Alzheimer Disease;lipid metabolism;Lipid Peroxidation;lipid transport;Lipids;Lipoproteins;Metabolism;Microglia;Microscopy;Molecular;mouse model;Mus;Natural Immunity;Nerve Degeneration;Nervous System;Neuroglia;Neurons;new therapeutic target;normal aging;novel;Older Population;particle;Pathway interactions;Play;prevent;Protein Isoforms;Proteins;Research;Resources;Risk;Role;Surface;Testing;Therapeutic;trafficking;United States;Visualization;Work

PROJECT_TITLE: Assessing the role of APOE in glial lipid droplet metabolism and function


NIH_SPENDING_CATS: Neurosciences;Sleep Research

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Relevance to human health Sleep disorders, mood disorders, obesity, and diabetes are global health hazards, and in recent years there has been a growing realization that these conditions are all linked. The goal of the proposed investigations is to provide new insights into the circadian clock, a biological timekeeping system that controls the sleep-wake cycle, feeding behavior, and metabolism. Deeper understanding of the circadian system could ultimately lead to improved diagnosis and treatment of sleep disorders, bipolar disorder, obesity, and diabetes.

PI_NAMEs: WEITZ, CHARLES J (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: 3-Dimensional;ARNTL gene;Behavior;Biochemical;Biological;Biological Pacemakers;Biological Process;Biological Rhythm;Bipolar Disorder;Brain;Cattle;Cells;Cerebral cortex;circadian;circadian pacemaker;Circadian Rhythms;Collaborations;Complex;Cryoelectron Microscopy;Defect;Diabetes Mellitus;Diagnosis;Diameter;Disease;DNA Binding;DNA Binding Domain;Electron Microscopy;Elements;experimental study;Feedback;Feeding behaviors;Freezing;Genetic Transcription;global health;Goals;Health;Health Hazards;Heart;Hour;Human;improved;in vivo;Incidence;insight;Investigation;Knowledge;Laboratories;Letters;Link;Malignant Neoplasms;Mammals;Mass Spectrum Analysis;Metabolic syndrome;Metabolism;Molecular;Mood Disorders;Multiprotein Complexes;Mus;Negative Staining;new therapeutic target;Nuclear Extract;Obesity;particle;Peripheral;Physiology;Play;Population;Preparation;Procedures;protein complex;Proteins;Resolution;Role;Sampling;screening;Sleep Disorders;Sleep disturbances;sleep health;sleep regulation;Sleep Wake Cycle;Source;Structure;success;System;Testing;Therapeutic;three dimensional structure;three-dimensional modeling;Tissues;Transcription Coactivator;transcription factor;two-dimensional;Work

PROJECT_TITLE: BMAL1 Circadian Clock Complexes from Mammalian Brain

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Substance Misuse

PHR: Project Narrative Some adolescents are especially susceptible to peer influence, which predicts their engagement in substance use. The study of neural networks, and how connectivity within and between these neural networks changes over adolescence, will offer important insights into why some adolescents are especially susceptible to peers and most at risk for substance use onset.

PI_NAMEs: LINDQUIST, KRISTEN ANN;TELZER, EVA HAIMO (contact)

PROGRAM_OFFICER_NAME: KAUTZ, MARY A

PROJECT_TERMS: Acceleration;Address;Adolescence;Adolescent;Affect;Age;Alcohols;American;Behavior;Biological;Brain;Brain region;Buffers;Cellular Phone;Childhood;cognitive control;cohort;comorbid depression;comorbidity;Complex;critical developmental period;Data;depressive symptoms;Development;Devices;digital;digital media;Drug usage;early adolescence;Ecological momentary assessment;emotion regulation;Emotions;executive function;experience;Exposure to;Family;Frequencies;Functional Imaging;Health;high school;Hour;Individual;Individual Differences;innovation;insight;Intervention;Learning;Link;longitudinal design;Marijuana;Measures;media use;Mediating;Mental Depression;Moods;Motivation;multilevel analysis;negative affect;neural;neural correlate;neural network;Neurobiology;neuroimaging;neuromechanism;neuroregulation;Neurosciences;Opioid;parent grant;Parents;Patient Self-Report;peer;peer influence;Perception;Performance;Predisposition;Process;promote resilience;prospective;protective effect;protective factors;psychologic;Psychopathology;Punishment;recruit;Reporting;Research;Rest;reward processing;Rewards;Risk;Sampling;Shapes;social;Social Environment;social influence;social media;Societies;Stress;Structure;substance use;successful intervention;System;time use;Tobacco;tv watching;Work;Youth

PROJECT_TITLE: Neurobiological susceptibility to peer influence and drug use in adolescence

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Narrative The proposed research is relevant to public health because understanding the mechanism of neural crest migration and cell fate determination is expected to deepen our understanding of the basic mechanisms of cell migration, informing the etiology of neural crest derived congenital birth defects. Thus, the proposed research is relevant to the part of the NIH mission that pertains to developing a fundamental knowledge that will help reduce the burdens of human disability.

PI_NAMEs: ARTINGER, KRISTIN  (contact);DUTTON, JAMES R.;PREKERIS, RYTIS

PROJECT_TERMS: 3' Untranslated Regions;Actins;Behavior;Binding;cancer cell;Candidate Disease Gene;Cartilage;Cell division;Cell model;cell motility;Cell Physiology;cell type;Cells;cellular imaging;Congenital Abnormality;Congenital Megacolon;craniofacial;CRISPR/Cas technology;Cues;Data;Defect;design;Development;Developmental Biology;Developmental Process;DiGeorge Syndrome;disability;Disease;Dorsal;Elements;epithelial to mesenchymal transition;Etiology;experimental study;Foundations;Goals;Human;human induced pluripotent stem cells;Image;In Vitro;in vivo;induced pluripotent stem cell;innovation;insight;Knowledge;Mandibulofacial Dysostosis;Membrane;Messenger RNA;migration;Mission;Modeling;Molecular;mRNA Expression;Mus;Mutate;Myosin ATPase;Nature;Neoplasm Metastasis;Neural Crest;Neural Crest Cell;neural plate;Neural tube;Neuroglia;neuroimaging;neuromechanism;Neurons;Nucleic Acid Regulatory Sequences;Peripheral Nervous System;Pigments;polarized cell;protein expression;Proteins;Proteome;Public Health;Research;Ribosomal RNA;RNA;Sequence Deletion;Signal Transduction;Site;Syndrome;Testing;Therapeutic;Time;trafficking;transcriptome;Translating;Translations;United States National Institutes of Health;Untranslated Regions;Work;Zebrafish

PROJECT_TITLE: RNA localization in neural crest migratory protrusions

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE: Virtually all vaccines rely on antibodies to protect us from infections. The proposal seeks to develop novel vaccine immunogens and strategies that can induce protective broadly neutralizing antibody responses. An effective vaccine could be a powerful intervention to slow and eventually eliminate new HIV infections, and thus the application is highly relevant to human health and welfare.

PI_NAMEs: ANDRABI, RAIEES AHMAD (contact);SHAW, GEORGE M

PROGRAM_OFFICER_NAME: MACIEL, MILTON

PROJECT_TERMS: Address;Affinity;aluminum sulfate;Animal Model;Animals;Antibodies;Antibody Affinity;Antibody Response;Antigens;Apical;arm;Automobile Driving;B-Cell Antigen Receptor;B-Lymphocytes;base;Binding;Biological Models;Biology;Biomedical Engineering;Cell Lineage;clinical translation;Collaborations;Consensus;cross reactivity;design;Development;Elements;Engineering;Epitopes;Exclusion;Exhibits;Failure;Germ Cells;Germ Lines;Grant;Health;HIV;HIV envelope protein;HIV Infections;HIV vaccine;HIV-1;HIV-1 vaccine;Human;Immunize;Immunoglobulin Gene Rearrangement;Immunoglobulin Somatic Hypermutation;in vivo;Infection;Intervention;Knock-in Mouse;Laboratories;Link;Macaca mulatta;Molecular;Molecular Conformation;mouse model;Mutagenesis;nanomolar;nanoparticle;neutralizing antibody;next generation;nonhuman primate;novel;novel strategies;novel vaccines;Pan Genus;Peptides;Phosphoserine;Polishes;Polysaccharides;pre-clinical;preclinical trial;prevent;Principal Investigator;Process;Property;Proteins;Regimen;Research;Research Design;response;Rhesus;Scheme;Science;simian human immunodeficiency virus;Site;SIV;Structure;Surface;T cell response;Talents;Testing;Time;tool;tool development;Translating;Vaccination;Vaccine Design;vaccine evaluation;Vaccine Research;vaccine strategy;vaccine-induced antibodies;Vaccines;Variant;virtual;Virus Replication;welfare;Work

PROJECT_TITLE: Combining germline-targeting, B cell immunofocusing and Env-Ab coevolution strategies to induce HIV Envelope V2-apex broadly neutralizing antibodies


NIH_SPENDING_CATS: Bioengineering;Neurodegenerative

ORG_DEPT: NEUROLOGY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The relevance of the proposed studies to public health is that they will define mechanisms by which the Heat Shock Protein molecular chaperones and protein unfoldases function as cell stress responders that dissolve toxic protein aggregates and amyloids. These studies propose to use cryo-electron microscopy and biochemical/biophysical approaches to determine structural snapshots which identify how these proteins interact and mechanically unfold their substrates. The resulting information will provide insight into mechanisms that protect cells from deleterious protein misfolding and aggregation, events that underlie the cause of many neurodegenerative diseases including Alzheimer's and Parkinson's disease.

PI_NAMEs: SOUTHWORTH, DANIEL RYLAND (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Acceleration;Address;alpha synuclein;Alzheimer's Disease;Amino Acids;Amyloid;amyloid formation;Architecture;ATP Hydrolysis;Binding;Biochemical;biological adaptation to stress;Biological Assay;biophysical techniques;Cell Aging;Cell Physiology;Cell Survival;Cellular Stress;Collaborations;Communication;Complex;Coupled;Coupling;crosslink;Cryoelectron Microscopy;Crystallization;Cytoprotection;Disease;Event;Family;Filament;Fluorescence Resonance Energy Transfer;Future;genetic regulatory protein;Goals;grasp;Heat shock proteins;human disease;Hydrolysis;improved;insight;Life;Mass Spectrum Analysis;Mechanics;Mediating;member;Methods;Mitochondria;Modeling;Molecular Chaperones;Molecular Conformation;Motor;multicatalytic endopeptidase complex;mutant;Nature;Neurodegenerative Disorders;novel strategies;Parkinson Disease;Pathway interactions;Peptide Hydrolases;polypeptide;prevent;protein aggregation;protein misfolding;protein protein interaction;Proteins;Proteolysis;proteostasis;Public Health;Resolution;Rotation;Science;single-molecule FRET;Site;Specific qualifier value;Stress;Structure;Substrate Interaction;sup35;Surface;System;therapeutic target;unfoldase;Variant;Work;yeast prion;Yeasts

PROJECT_TITLE: Mechanisms of Protein Disaggregation and Turnover by AAA+ Chaperones

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pregnancy;Prevention;Serious Mental Illness;Sleep Research;Women's Health Research

PHR: PROJECT NARRATIVE This research will provide definitive evidence about whether treating prenatal insomnia with digital cognitive behavior therapy for insomnia prevents depression during the perinatal period (i.e., pregnancy and the postpartum period). Currently, there are few intervention options for preventing perinatal depression, none focus on women with prenatal insomnia, and the accessibility of existing interventions is limited. Several attributes of our approach will facilitate its broad dissemination, including focusing on the low stigma target of insomnia and using a scalable intervention, with significant public health impact for reducing the burden of perinatal depression for mothers, children, families, and society.

PI_NAMEs: MORAN, PATRICIA  (contact)

PROGRAM_OFFICER_NAME: CHU, SERENA PO-LAN

PROJECT_TERMS: Address;animation;antepartum depression;Arousal;Belief;Blinded;Child;Child Rearing;Childbirth;Clinical Trials Design;clinically relevant;Cognitive;Cognitive Therapy;comparison group;Complication;confirmatory trial;Data;depression prevention;depressive symptoms;design;digital;Education;Educational Intervention;efficacy evaluation;efficacy testing;emotion regulation;Enrollment;experience;Family;flexibility;follow-up;Frequencies;Health Expenditures;Impairment;improved;Incidence;interest;Intervention;Knowledge;Major Depressive Disorder;Mediating;Mediator;Medicaid services;Mental Depression;Mothers;Outcome;Participant;Perinatal;perinatal depressive symptom;perinatal period;peripartum depression;Population;Postpartum Depression;Postpartum Period;preference;Pregnancy;Pregnant Women;prenatal;prenatal experience;prevent;Prevention;preventive intervention;primary outcome;productivity loss;programs;Public Health;Randomized;Randomized, Controlled Trials;Recording of previous events;Research;Research Personnel;Risk Factors;Schedule;Severities;Sleep;sleep health;Sleeplessness;social stigma;societal costs;Societies;standard care;suicidal risk;symptomatic improvement;Symptoms;Testing;Therapeutic;Therapeutic Intervention;Thinking;Training;Travel;Wait Time;web site;welfare;Woman

PROJECT_TITLE: Efficacy of digital cognitive behavior therapy for insomnia for the prevention of perinatal depression


ADMINISTERING_IC: MD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homicide and Legal Interventions;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Substance Misuse;Violence Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Little is known about how the social determinants of health (SDoH), the arrangement and quality of neighborhoods alcohol outlet hours of operation influence gun violence events and risk. This project will utilize cutting-edge spatial science approaches to understand the spatial and temporal dynamics of gun violence in Washington, D.C. at the neighborhood level from 2014-present. Results from this research could improve our understanding of the SDoH, segregation, spatial and temporal interaction, and relationships with other factors that are necessary to improve gun violence reduction programs and policy.

PI_NAMEs: DESJARDINS, MICHAEL RICHARD (contact)

PROGRAM_OFFICER_NAME: PICHARDO, CATHERINE MELISSA

PROJECT_TERMS: Adult;aged;alcohol availability;Alcohol consumption;alcohol outlet density;Alcohols;Area;Behavioral;black men;Black race;built environment;Capital;career;career development;Cause of Death;Censuses;Communities;community violence;Complement;Criminology;Data;data access;Development Plans;Disparity;Economics;Education;education access;Ethnic Origin;Event;Exhibits;experience;Firearms;Foundations;Funding;gang;Goals;Gun injury;gun violence;Health;health care availability;Health Policy;high risk;Homicide;Hour;Human;improved;Individual;Interruption;K-18 conjugate;Lawyers;Link;men;Mentors;Modeling;Monitor;mortality;neighborhood disadvantage;neighborhood safety;Neighborhoods;Not Hispanic or Latino;operation;Outcome;Paper;Pharmaceutical Preparations;Policies;Policy Maker;Poverty;Prevention;programs;prospective;protective effect;Public Health;racial disparity;Reporting;Research;Research Personnel;Risk;Science;segregation;social;social health determinants;Teenagers;Time;Time trend;tool;Training;Training Activity;United States;Violence;Washington;Work

PROJECT_TITLE: Spatial Science Approaches to Enhance Gun Violence Surveillance and RelatedDeterminants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (51)]