NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BANGOR

ORG_NAME: WABANAKI HEALTH AND WELLNESS

ORG_STATE: ME

PI_NAMEs: CAMMACK, RALPH  (contact);PETRIE, REBECCA ;SOCKABASIN, LISA

PROJECT_TERMS: Address;American;Area;Automobile Driving;Biological Models;California;Censuses;Collaborations;Communities;Community Surveys;COVID-19 pandemic;Data;data modeling;Data Set;Decision Making;Disparity;Economics;Epidemiology;Face;Family;Farm;Fishes;Food;Food Access;food insecurity;food security;Friends;Funding;Health;Household;Housing;Improve Access;improved;Indigenous;innovation;Intervention;land use;Maine;Modeling;Native American Research Center for Health;Native Americans;Oregon;Outcome;Patient Self-Report;Persons;Policies;Population;programs;Public Health;Recovery;Reporting;Resources;Salmon;social health determinants;Source;Surveys;System;tool;tribal community;tribal leader;Tribes;United States Department of Agriculture;United States Indian Health Service;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: Improving Health Outcomes Through Systems and Policy changes in Maine


ADMINISTERING_IC: OD

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: LITTLE ROCK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ARKANSAS CANCER COALITION

ORG_STATE: AR

PI_NAMEs: KARANJA, MIRIAM N.;MITCHELL, TRENA  (contact)

PROGRAM_OFFICER_NAME: MADDEN, EBONY B

PROJECT_TERMS: Address;African American population;Area;Arkansas;Black race;Breast;Breast Cancer Detection;built environment;Cancer Burden;cancer health disparity;Caring;Chronic Disease;Colonoscopy;colorectal cancer screening;Communities;community based participatory research;Community Developments;concept mapping;County;Data Analyses;Death Rate;Development;Disadvantaged;Economic Burden;efficacy evaluation;Equity;family burden;follow-up;Goals;Health;health care availability;Health Disparities Research;health disparity;health equity;Health Food;Health Services;Health system;Inequity;Infrastructure;innovation;Intervention;Interview;Life Expectancy;Lung;lung cancer screening;Malignant Neoplasms;Maps;Measurable;Medical;medically underserved;Methods;mortality;National Institute on Minority Health and Health Disparities;Needs Assessment;Neighborhoods;novel strategies;Occupations;Persons;Policies;Population;Positioning Attribute;Poverty;poverty reduction;Process;Race;Research;Resources;Rural;rural area;rural dwellers;rural underserved;Science;screening;Screening for cancer;screening program;Services;skills;Social Environment;social structure;structural determinants;success;Surveys;System;Testing;theories;therapy design;Time;tool;Transportation;underserved rural area;Universities;voucher;Work

PROJECT_TITLE: Cancer in Your Community: Strategies to Reduce Cancer and Chronic Disease in the Arkansas Delta

STUDY_SECTION: CFOT

STUDY_SECTION_NAME: Common Fund Other Transactions Programs[CFOT(01)-1]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: RALEIGH

ORG_NAME: NC STATE DEPT/HLTH & HUMAN SERVICES

ORG_STATE: NC

PI_NAMEs: CONNAUGHTON-ESPINO, TANIA CORINA;FREEMAN, ELIZABETH  (contact)

PROJECT_TERMS: access disparities;Address;agricultural community;Agricultural Workers;Agriculture;Area;Censuses;Chronic;Chronic Disease;Clinic;Communication;Communities;community engagement;Community Health;Community Health Aides;community led intervention;community partners;Comprehensive Health Care;Cross-Sectional Studies;Crowding;Data;Diabetes Mellitus;digital;digital divide;Disease Management;Economics;electronic health record system;Emergency Situation;Equity;Essential worker;Ethnic Origin;experience;Family;farm worker;Food;food insecurity;Friends;Health;health care delivery;health determinants;Health equity research;health inequalities;Health Services Accessibility;Healthcare Systems;Hospitals;Housing;Hypertension;improved;Inequity;Information Systems;innovation;Internet;intervention mapping;Learning;Medical;member;Mental Health;Migrant;Modeling;Neighborhood Health Center;next generation;North Carolina;Occupations;Outcome;pandemic response;Participant;Patients;pesticide exposure;poor health outcome;population health;Price;primary care services;primary health service;Privacy;programs;Race;Research;Resources;Risk Factors;Rural;rurality;Service delivery model;Site;social determinants;Societies;Speed;Stress;student participation;System;telehealth;theories;virtual;Vision;Voice;Weather;Work

PROJECT_TITLE: Agricultural Workers Digital Equity Initiative


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: HOUSING AUTHORITY OF THE CITY OF LOS ANGELES

ORG_STATE: CA

PI_NAMEs: KUBICEK, KATRINA  (contact)

PROJECT_TERMS: Address;Advocate;Affect;African American;Age;Area;authority;Black race;built environment;Businesses;California;Chronic;Chronic Disease;Cities;clinical care;Communities;community collaboration;community engagement;Community Health;Community Networks;community research;community-level factor;cost;Criminal Justice;deprivation;design;Diabetes Mellitus;Discrimination;Disparity;Economics;Education;Employment Opportunities;Environment;Environmental Health;evidence base;experience;Food;food insecurity;Forestry;Funding;Future;Genetic;Green space;Health;health disparity;health economics;Health Food;Health Services Accessibility;Health Status;Housing;improved;Inequity;innovation;Intervention;intervention mapping;intervention refinement;Investments;Knowledge;Latinx;Life Expectancy;Los Angeles;member;Methods;neglect;Neighborhoods;Obesity;Outcome;people of color;Personal Behavior;Personal Satisfaction;Persons;Physical activity;physical conditioning;Policy Maker;Pollution;population health;Prevention;Process;programs;Provider;Qualifying;Quality of Care;Quality of life;Recording of previous events;Recreation;Reduce health disparities;Research Personnel;Resources;Safety;Secure;Services;social;social health determinants;Social support;Socioeconomic Status;socioeconomics;Source;structural determinants;success;Translating;Transportation;underserved community;United States;Universities;Vision;walkability;Work;Workforce Development

PROJECT_TITLE: Watts Rising: A Vision for a Healthier Watts


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: CULTURA Y ARTE NATIVA DE LAS AMERICAS

PI_NAMEs: HERNANDEZ, ROBERTO Y (contact);STOJSAVLJEVIC-FLORES, PAUL

PROJECT_TERMS: Address;Admission activity;Adrenal Glands;Affect;alcohol risk;alcohol use disorder;American Indians;Americas;Anxiety;Area;Arts;bilingualism;Black race;Businesses;California;Cardiovascular system;Chronic;Chronic Disease;Cities;Collaborations;Color;Communities;community based participatory research;Community Developments;community partners;community partnership;Community Workers;Coronary Arteriosclerosis;COVID-19;COVID-19 pandemic;Development;Diabetes Mellitus;Dimensions;Discrimination;Disease;Dyslipidemias;Economic Development;Economics;Entrepreneurship;Environment;environmental stressor;epidemiology study;Essential worker;Evaluation Research;evidence base;experience;Family;Food;Food Access;Funding;Goals;Government;healing;Health;health determinants;health disparity;health equity;health inequalities;Health Services;Home;Hospitalization;Housing;Hypertension;Hypothalamic structure;improved;Indigenous;Individual;Inequity;Infrastructure;innovation;Insulin Resistance;Intensive Care Units;Intervention;Latino;Latino Population;Measurement;member;Mental Depression;Mental Health;Mental Health Services;Metabolic;minority communities;Mission;neighborhood disadvantage;Obesity;Outcome;Outcome Study;Ownership;pandemic disease;Personal Satisfaction;physical conditioning;Physiological;Policies;Politics;post-COVID-19;Poverty;programs;Property;Public Health;Quality of life;Race;racial disparity;racism;Recovery;Research;Research Methodology;Research Personnel;Resources;Risk;Running;San Francisco;science and society;Scientific Advances and Accomplishments;service organization;social;social determinants;social disparities;square foot;Stress;structural health determinants;Substance Use Disorder;Testing;United States National Institutes of Health;Universities;Work;Workforce Development

PROJECT_TITLE: Somos Esenciales: Community Revitalization and Health through Latino Arts and Entrepreneurship


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MIAMI

ORG_NAME: HEALTH CHOICE NETWORK, INC.

ORG_STATE: FL

PI_NAMEs: CHUNG-BRIDGES, KATHERINE  (contact)

PROJECT_TERMS: Address;Area;Attention;Awareness;Black Populations;Blood Pressure;Body mass index;Caring;Clinic;Clinical Sciences;Collaborations;Communities;community advisory board;Community Health;Community Health Aides;Community Health Systems;community organizations;Complex;cost;Dedications;Disparity;Economics;Education;Eligibility Determination;Environment;ethnic minority;experience;Family health status;Federally Qualified Health Center;feeding;Florida;Food;food insecurity;Funding;glycemic control;Goals;Government Programs;Health;health care service utilization;Health Disparities Research;Health equity research;Health Food;health plan;Health Policy;high risk population;Hispanic Populations;Home;Household Heads;improved;innovation;insight;Institution;Intervention;Knowledge;Lipids;Location;Low income;Managed Care Programs;Measures;Medicaid;Mental Health;Modeling;Not Hispanic or Latino;Outcome;Participant;patient navigation;patient oriented;Patients;Persons;Phase;physical conditioning;Pilot Projects;Policies;Policy Maker;Politics;poor health outcome;Population;Preparation;Privatization;Process;programs;Qualifying;racial minority;Reduce health disparities;Reporting;Research;Resources;safety net;scale up;screening;Series;social;social determinants;social health determinants;Socioeconomic Status;Supermarket;System;therapy design;Translational Research;Transportation;Underrepresented Minority;underserved community;United States Health Resources and Services Administration;United States National Institutes of Health;Universities

PROJECT_TITLE: Addressing Food Insecurity in Underserved Communities


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ALBUQUERQUE

ORG_NAME: ALBUQUERQUE AREA INDIAN HEALTH BOARD

ORG_STATE: NM

PI_NAMEs: YAZZIE, SHELDWIN A (contact)

PROJECT_TERMS: Address;Affect;Area;Arizona;Asthma;biological adaptation to stress;clinical training;Communities;community based participatory research;Community Health;Community of Practice;Country;cultural competence;Disease Management;Disparity;Environmental Exposure;Environmental Health;Epidemiology;fall injury;Family;flexibility;hazard;Health;Health Priorities;Home;Home environment;Household;Housing;improved;Indigenous;Individual;injury prevention;innovation;Intervention;Knowledge;Lead;Maintenance;medical specialist;Methodology;Mission;Modification;New Mexico;novel;Outcome;Parents;Participant;Personal Satisfaction;Persons;programs;protocol development;Public Health;Quality of life;repaired;Research;Research Project Grants;resilience;Resources;respiratory health;Risk;service programs;social health determinants;Southwestern United States;Stress;stressor;structural determinants;tool;Training;Training Activity;tribal community;Tribes;United States Indian Health Service;Universities;voucher;Work;Workforce Development

PROJECT_TITLE: Indigenous healthy homes and healthy communities: A community-led initiative to improve health and support Indigenous Resilience in the US Southwest


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: FORT WORTH

ORG_NAME: HEALTHY TARRANT COUNTY COLLABORATION

ORG_STATE: TX

PI_NAMEs: FULMER, LINDA  (contact)

PROJECT_TERMS: Acute;Address;Affect;Behavior;Black American;Black Populations;Black race;caucasian American;Color;Communities;community advisory board;community engagement;Conflict (Psychology);County;Criminal Justice;Data;Death Rate;design;Diffusion of Innovation;Distal;Effectiveness;efficacy evaluation;Epidemiology;Ethnic Origin;Evaluation;experience;Family;Funding;Gender Identity;gender minority group;Goals;Health;health determinants;health disparity;health equity;health inequalities;Healthcare;Home;Immigrant;Immigration;implementation process;Imprisonment;improved;Individual;Inequality;innovation;Intervention;Jail;Latinx;Law Enforcement;Laws;Legal system;Lesbian Gay Bisexual Transgender Queer;Life Cycle Stages;Lived experience;marginalized population;member;Mental Health;Methods;Minority Groups;Outcome;Persons;Phase;physical conditioning;Police;Policies;Politics;Population;population health;Precede-Proceed Model;prison population;Process;Race;Research;Risk;Role;Sex Behavior;Sexual and Gender Minorities;sexual identity;sexual minority group;Shapes;social;structural determinants;System;Testing;Texas;therapy development;Violence;Work;Workplace

PROJECT_TITLE: Macro-level Health Considerations of Community and Criminal Justice System Relationships in North Texas


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Teenage Pregnancy;Women's Health Research

ORG_CITY: STONEVILLE

ORG_NAME: DELTA HEALTH ALLIANCE, INC.

ORG_STATE: MS

PI_NAMEs: MATTHEWS, KAREN COMER (contact)

PROJECT_TERMS: abortion;Address;Advocate;Affect;Area;behavioral health;Birth;black women;Businesses;Child;Chronic Disease;Color;Communities;community center;community engaged research;community research;Contraceptive methods;Country;County;COVID-19 vaccination;Disadvantaged;Economics;Elements;Environment;Equity;Evaluation;experience;Face;Faith;Family Planning;Future;Geography;Health;Health Alliance;health care availability;health care service;health disparity;health equity;Health equity research;Health Policy;Health Services Accessibility;Home visitation;improved;improved outcome;Incidence;Infant;Infant Health;infant morbidity/mortality;innovation;Insurance Coverage;interest;Intervention;Intervention Studies;Laws;Legal;long-standing disparities;Low income;marginalized community;marginalized population;Maternal Health;Maternal Mortality;Measures;Medicaid;member;Methodology;Methods;Minority;Misinformation;Mississippi;Mothers;multi-component intervention;novel;Nurse Practitioners;nutrition;Outcome;payment;Personal Satisfaction;Physicians;Policies;Policy Developments;policy implication;Policy Maker;postpartum care;Poverty;Predisposition;Pregnancy;pregnancy health;Pregnancy in Adolescence;primary care services;Public Health;Regulation;Religious Belief;Reproductive Health;Research;Resources;reversible contraceptive;Rights;Rural;Rural Community;rural dwellers;Safety;safety net;Services;social;social service provider;Social Work;structural determinants;System;Target Populations;Training;unintended pregnancy;Vulnerable Populations;Woman;Women's Health;Work

PROJECT_TITLE: Partnership to Optimize Equity in Maternal and Infant Health


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: NOGALES

ORG_NAME: SOUTHEAST ARIZONA AREA HEALTH EDUCATION CENTER

ORG_STATE: AZ

PI_NAMEs: EMRICK, GAIL  (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Area Health Education Centers;Arizona;behavioral health;Border Community;Communities;community organizations;community partners;cost;COVID-19 pandemic;Dimensions;effective intervention;ethnic minority population;Evaluation;experience;Feedback;frontier;Future;Goals;Government;Health;health care availability;health determinants;health disparity;health equity;health equity promotion;health inequalities;Health Services;Healthcare;Hispanic;implementation strategy;Improve Access;improved;Inequity;insight;Intervention;Latino;marginalization;Measurable;member;Mental disorders;Mental Health;Methods;Modeling;Nature;Phase;Politics;Positioning Attribute;Psyche structure;Public Health;Public Policy;racial minority population;Research;Resources;Rural;social;structural determinants;Substance Use Disorder;Testing;Trust;United States;Work

PROJECT_TITLE: Proyecto Juntos


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: ASIAN COMMUNITY HEALTH COALITION

ORG_STATE: PA

PI_NAMEs: WU, DUNLI  (contact)

PROJECT_TERMS: access disparities;Address;Adoption;Adult;American;anti-Asian;Area;Asian;Asian Americans;barrier to care;Black race;Chronic;Chronic Care;Chronic Disease;Clinical;Collaborations;collaborative approach;Communities;Community Health;Community Health Aides;community organizations;Community-Led Health Equity Structural Intervention;comorbidity;COVID-19;COVID-19 mortality;COVID-19 pandemic;Crowding;Data;Data Aggregation;Data Analyses;Data Collection;Development;Diabetes Mellitus;Diet;Discrimination;Disease;disease disparity;Disparity;District of Columbia;Education;Ethnic Origin;Ethnic Population;Evidence based intervention;Exclusion;experience;Face;Faith-based organization;food security;Fright;Funding;Goals;Government;Guidelines;Hate;Health;Health behavior;health care availability;Health Care Rationing;health care service;Health Disparities Research;health disparity;Health Insurance;Health Services Accessibility;Healthcare;Heart Diseases;Height;Hepatitis;HIV/AIDS;Home;Hypertension;Immigrant;implementation intervention;improved;Incidence;Individual;Industry;innovation;Intervention;Language;Latinx;Laws;Legal;Level of Evidence;Long COVID;low health literacy;Low income;Malignant Neoplasms;Maryland;Masks;Medical;member;Mental Health;Mental Health Services;Metabolic Diseases;Minority;Misinformation;Modeling;Monitor;Multilingualism;Native Americans;Neighborhood Health Center;Neighborhoods;New Jersey;Outcome;outcome disparities;Pacific Islander;pandemic disease;Phase;Philadelphia;Police;Policies;Population;prevent;Prevention;Preventive care;Preventive screening;Process;Provider;Public Health;Public Health Schools;racial population;racism;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;Research;Resources;Restaurants;SARS-CoV-2 infection;screening;Services;Shapes;Smoking;social;social health determinants;Subgroup;success;systemic barrier;Universities;urban area

PROJECT_TITLE: Asian Community-Led Health Equity Structural Intervention (Asian CHESI)


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: RELEVANCE The ultimate goal of this proposal is to uncover how pre-mRNA splicing and trafficking through nuclear speckles is controlled by the kinase TAO2, and why TAO2 is required for successful Influenza virus (IAV) replication. This work will have implications not only for viral infections but also for general mechanisms of RNA splicing and nuclear speckle function.

PI_NAMEs: COBB, MELANIE H.;FONTOURA, BEATRIZ MA;LYNCH, KRISTEN W (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Alternative Splicing;Biochemical;Biochemistry;Biological Assay;Cell Nucleus;Cells;Chemicals;Complement;Creativeness;Data;Economic Burden;Event;experience;Gene Expression;Genes;genetic manipulation;Genetic Transcription;Goals;Grant;Health;high resolution imaging;Human;Immune response;Impairment;Infection;influenza infection;Influenza Virus Infected Cells;influenzavirus;insight;Integration Host Factors;knock-down;Label;Link;Maintenance;Mass Spectrum Analysis;Mediating;Messenger RNA;Methods;Microscopy;Morphology;mRNA Precursor;Nuclear;Nuclear Proteins;Nuclear RNA;Phosphorylation;Phosphotransferases;Positioning Attribute;Process;Protein Kinase;Proteins;Regulation;RNA;RNA Processing;RNA Splicing;RNA-Binding Proteins;Role;Shapes;therapeutic target;trafficking;Transcript;transcriptome sequencing;Viral;Viral Genes;Viral Proteins;viral RNA;Virus;Virus Diseases;Virus Replication;Western Blotting;Work

PROJECT_TITLE: Kinase Regulation of Nuclear Speckle Function and Splicing during Influenza Virus Infection

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Contraception/Reproduction;Estrogen;Eye Disease and Disorders of Vision;Genetics;Menopause;Neurodegenerative;Neurosciences;Women's Health Research

ORG_CITY: AUGUSTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Project Narratives The goal of this proposal is to determine the role of estrogen and its receptors (estrogen receptor 1 and G protein coupled estrogen receptor 1) in regulating eye pressure by affecting the different parts in the anterior chamber of the eye. Eye pressure is the primary and only treatable risk factor with glaucoma patients in the clinic. The successful completion of this project will help uncover critical information on the specific roles of estrogen and its signaling pathways in regulating eye pressure and identify new treatment targets to lower eye pressure more effectively in glaucoma patients.

PI_NAMEs: LIU, YUTAO  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: 4-vinylcyclohexene diepoxide;Affect;Age;Age at Menarche;Agonist;antagonist G;Anterior;anterior chamber;aqueous;Aqueous Humor;Aromatase;Bioinformatics;Cattle;Cell Physiology;Cells;Chemicals;Clinic;Clinical;contrast imaging;Cornea;Data;Disease;Endothelial Cells;ERR1 protein;ESR1 gene;Estradiol;Estrogen decline;Estrogen Receptors;Estrogens;Extracellular Matrix;Eye;eye chamber;Eyedrops;Family suidae;Female;Fertility;follow-up;gene network;Genes;genetic association;genome wide association study;genomic locus;Glaucoma;Goals;GPER gene;Heterozygote;Histology;Hormone replacement therapy;Hormone use;Human;human old age (65+);In Vitro;in vivo;Individual;inhibitor;Injections;innovation;Knockout Mice;Magnetic Resonance Imaging;Mechanics;Mediating;Menarche;Menopause;Modeling;modifiable risk;Monitor;mouse model;Mus;Nerve Degeneration;Nerve Fibers;new therapeutic target;NG-Nitroarginine Methyl Ester;Nitric Oxide;NOS3 gene;novel;Ocular Hypertension;Oral Contraceptives;Ovariectomy;Pathogenesis;Pathway interactions;Patients;Periodicity;Physiologic Intraocular Pressure;Physiological;Postmenopause;Pregnancy;pressure;Primary Cell Cultures;Primary Open Angle Glaucoma;Production;protective effect;Proteins;Rattus;receptor;Receptor Signaling;Regulation;Research;Resistance;response;Retina;Retinal Degeneration;Risk;Risk Factors;Role;sex;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Stains;stem;Steroids;Stretching;Structure of sinus venosus of sclera;System;Testing;therapeutic target;Thick;Tissues;Trabecular meshwork structure;Transforming Growth Factor beta;Variant;Vision;Visual Fields;Woman

PROJECT_TITLE: Estrogen and its Receptor in Intraocular Pressure Regulation

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLLEGE PARK

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: This MIRA proposal will develop sampling algorithms at the interface of statistical mechanics and artificial intelligence to probe mechanisms for rare event processes, such as drug unbinding and conformational change in drug targets. These algorithms will be used to guide mechanistically driven design of inhibitors of Src, Abl kinases and PreQ1 riboswitches.

PI_NAMEs: TIWARY, PRATYUSH  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Algorithms;Area;Artificial Intelligence;Artificial Intelligence enhanced;Awareness;Biology;Chemicals;Computing Methodologies;conformational conversion;design;Development;Dissociation;Drug Design;drug discovery;Drug Targeting;Event;Generic Drugs;Human;inhibitor;Intervention;Kinetics;Learning;learning strategy;Ligands;Maps;Methods;Modeling;Modification;Molecular;Molecular Conformation;molecular dynamics;National Cancer Institute;Natural Language Processing;Nature;neural information processing;Pharmaceutical Preparations;Phosphotransferases;Process;programs;Reaction;Research;Sampling;simulation;Statistical Mechanics;Structure;Thermodynamics;Tyrosine Kinase Inhibitor;Universities;Work

PROJECT_TITLE: From atoms to mechanisms - Artificial Intelligence augmented molecular simulations for mechanistic ligand design

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-G(07)R]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Data Science;Neurosciences;Pain Research;Pediatric

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE There is a considerable societal need to better understand neurobiological mechanisms, psychosocial processes, treatments, preventions, and policy in child and maternal pain. This training program aims to develop the next generation of interdisciplinary and diverse scientific leaders in child and maternal pain.

PI_NAMEs: SIMONS, LAURA E (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TERMS: Adolescent;Anesthesiology;Area;Behavioral;behavioral health;Behavioral Sciences;Bioinformatics;biomedical data science;biopsychosocial;career;career development;Child;Childhood;clinical pain;Clinical Research;Clinical Services;cohort;Data Science;Ensure;Epidemiology;Evaluation;experience;faculty mentor;faculty research;Fostering;Funding;Goals;Health;health equity;Health Services Research;Helping to End Addiction Long-term;Institution;Interdisciplinary Study;Intervention;life span;Lived experience;Maternal and Child Health;Maternal Health;medical schools;Medicine;Mentors;Mentorship;Monitor;neurobiological mechanism;Neurosciences;next generation;Output;Pain;pain chronification;pain model;Pain Research;Participant;Patients;pediatric department;Pediatrics;Perioperative;Policies;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Prevention;Process;Productivity;programs;Psychiatry;psychosocial;R24;Records;Research;Research Institute;Research Methodology;Research Training;Schools;Science;Scientist;Secure;skill acquisition;skills;social stigma;Statistical Methods;success;Time;Training;Training Programs;United States National Institutes of Health;Universities;web site;webinar;whole health

PROJECT_TITLE: Interdisciplinary research training in maternal and childhood pain


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Prevention

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE There is an epidemic of chronic kidney disease in Central America and mortality rates are highest in El Salvador and Nicaragua. This Field Epidemiology Site will recruit 800 residents of the most affected regions of each country including ~400 people with low kidney function at baseline, and ~400 people with high or healthy kidney function at baseline, including men and women. We will follow them for three years to examine kidney function and disease progression over time, and exposure to multiple environmental, social, behavioral and occupational risk factors as part of the Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium.

PI_NAMEs: SCAMMELL, MADELEINE  (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Acceleration;Affect;Age;Agonist;agricultural community;Agricultural Workers;Agriculture;Air Pollution;Alcohols;Asia;Behavior;Behavioral;Biological;Boston;Cause of Death;Central America;Chemicals;Chronic Kidney Failure;Clinical assessments;cohort;Collaborations;Communication;Communities;community research;Complex Mixtures;Consent;Country;Data;Data Coordinating Center;Death Rate;Dehydration;design;Developing Countries;Diabetes Mellitus;Diagnosis;Diet;Disease;Disease Progression;Disease susceptibility;drinking water;Early Diagnosis;early onset;El Salvador;Environment;Epidemic;Epidemiologic Research Design;Epidemiology;Epigenetic Process;Ethics;Etiology;Europe;experience;Exposure to;Family member;Flame Retardants;General Population;Generations;Genetic Predisposition to Disease;Goals;Government;Heat Stress;Heavy Metals;high risk;high risk population;Home;Hot Spot;Hypertension;India;Individual;Infectious Agent;Inherited;Injury to Kidney;International;Kidney;Kidney Diseases;Life Style;male;men;mortality;nephrotoxicity;Nicaragua;Nicaraguan;Nutritional status;Occupational;Older Population;Participant;Pathology;Persons;Pharmaceutical Preparations;Population;Predisposition;Prevalence;Prevention;Procedures;progression risk;Protocols documentation;Public Health;public health intervention;Questionnaires;Recording of previous events;recruit;Renal function;Research;Research Personnel;Risk;Risk Factors;Salvadoran;Sampling;Science;Severity of illness;Site;social;Sri Lanka;Standardization;therapeutic target;Time;Toxic effect;trait;United States National Institutes of Health;Universities;Woman;Work;working men;young man

PROJECT_TITLE: CKDu in Salvadoran and Nicaraguan Agricultural Communities


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Physical Activity;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative There is accumulating evidence showing that the circadian system plays a critical role in many physical activity-related pathways and regulates the diurnal variations in the cardiometabolic responses to physical activity. This raises the question whether timing may modulate the adaptive responses of physical activity, and can thus be used to enhance the health benefits of physical activity. Here, we aim to test the relationship between timing of physical activity and cardiometabolic outcomes in humans, with the hope of providing mechanistic insights that may assist in the design of lifestyle interventions to improve the efficacy of physical activity.

PI_NAMEs: QIAN, JINGYI  (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Accelerometer;Address;age related;Animals;Area;Autonomic nervous system;Behavioral;Beta Cell;Blood Pressure;Body fat;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Physiology;career development;Cell Physiology;Chronobiology;circadian;circadian pacemaker;Clinical Trials Design;combat;Crossover Design;Data;Data Set;Dedications;design;Diabetes Mellitus;disorder risk;Diurnal Rhythm;Energy Intake;Energy Metabolism;Environment;Epidemic;Epidemiology;evidence base;Exercise;exercise intervention;Exercise Physiology;experience;experimental study;Fatty acid glycerol esters;follow-up;Foundations;Frequencies;Funding;Glucose;Glycosylated hemoglobin A;Goals;Health;Health Benefit;Hour;Human;improved;Individual;innovation;insight;insulin sensitivity;Knowledge;Laboratories;laboratory experiment;Laboratory Study;lifestyle intervention;Link;Low-Density Lipoproteins;Mentors;Metabolic Pathway;Metabolism;Modality;multidisciplinary;Non-Insulin-Dependent Diabetes Mellitus;obese patients;Observational Study;Outcome;Overweight;oxidation;Pathway interactions;Patients;Peripheral Resistance;Persons;Phase;Physical activity;Physiological;Physiology;Play;Prediabetes syndrome;pressure;prevent;primary endpoint;programs;Protocols documentation;Randomized;Randomized, Controlled Trials;Recommendation;Research;Research Design;response;Rest;Risk Reduction;Role;Schedule;secondary endpoint;skills;System;Testing;Time;Tissues;Training;Transcript;Triglycerides;United States National Institutes of Health;Visceral fat;weight loss program

PROJECT_TITLE: Timing of Physical Activity on Cardiometabolic Health Outcomes

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Diabetes;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PISCATAWAY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Diabetic retinopathy is the leading cause of blindness in working-age adults with more than 190 million worldwide projected to be affected by 2030. This project will develop a computer model to predict initiation and progression of diabetic retinopathy based on changes in blood flow in retinal vessels that are caused by changes in the properties of blood cells and vessel structure due to their prolonged exposure to diabetic conditions. The detailed and accurate prediction from this model may provide novel insights on blood flow-mediated pathogenesis of retinopathy, and reliable metrics for early disease detection, thereby directly benefiting clinical diagnosis and treatment. An Administrative Supplement is requested to purchase a high-performance computing system to perform the modeling study.

PI_NAMEs: BAGCHI, PROSENJIT  (contact)

PROGRAM_OFFICER_NAME: GAO, JAMES

PROJECT_TERMS: 3-Dimensional;Administrative Supplement;Adult;Affect;Age;Appearance;Biological Availability;biophysical properties;Biophysics;Blindness;Blood;Blood capillaries;Blood Cells;Blood flow;Blood Vessels;Cells;clinical diagnosis;Clinical Treatment;Complex;Computer Models;Computer Systems;Coupling;Data;Detection;Development;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Disease;Endothelial Cells;Erythrocytes;Exposure to;Gases;Geometry;hemodynamics;Hemorrhage;Heterogeneity;high end computer;High Performance Computing;Homeostasis;human imaging;Hypoxia;Image;Imaging Techniques;in silico;in vivo imaging;Individual;innovation;insight;Measurement;Mediating;Modeling;Morphology;multi-scale modeling;Nature;Nitric Oxide;novel;Pathogenesis;Pathway interactions;predictive modeling;Property;Regulation;research clinical testing;Retina;retina blood vessel structure;Retinal Diseases;retinal imaging;Rheology;Role;Severity of illness;simulation;Structure;Study models;tissue oxygenation;Tissues;Variant;vascular abnormality;Virulence Factors

PROJECT_TITLE: Development and application of a high-fidelity computational model of diabetic retinopathy hemodynamics: Coupling single-cell biophysics with retinal vascular network topology and complexity


NIH_SPENDING_CATS: Contraception/Reproduction;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: PEDIATRICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative We have recently shown that T cells in the placental villi are active and inflammatory during intraamniotic inflammation, a process commonly associated with preterm birth. In this grant application, we will use our combined expertise in mucosal immunology (L. Konnikova), placental biology (V. Abrahams, S. Guller), placental pathology (R. Morotti) and bioinformatics (G. Tseng) to uncover placental villi T cell abnormalities in preterm births. We will use our current biorepository and ongoing collection of placental specimens to: (1) delineate T cell surface phenotypes, anatomic localization, activation mechanisms, and transcription, and TCR profiles unique to preterm placental villi and (2) interrogate the downstream effects of T cell activation on surrounding trophoblast cells as a potential mediator of preterm labor.

PI_NAMEs: KONNIKOVA, LIZA  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: 37 weeks gestation;Abnormal Cell;Activities of Daily Living;adaptive immunity;adverse outcome;Agreement;Anatomy;Animal Model;Antigen Presentation;Antigen-Presenting Cells;Antigens;Apoptosis;Applications Grants;Architecture;biobank;Bioinformatics;Biological Assay;Biology;Cause of Death;Cell Proliferation;Cell secretion;Cell Separation;Cell surface;Cells;Child;Childbirth;Chorionic villi;Clone Cells;Coculture Techniques;Collection;comparative;cost;Coupled;Cryopreservation;cytokine;Cytometry;Data;Development;Environment;Evaluation;experimental study;Exposure to;Gene Expression Profile;Genetic Transcription;Goals;Health;healthy pregnancy;HLA-DR Antigens;Homeostasis;Human;human data;human tissue;Immune;Immune Tolerance;Immunology;Immunophenotyping;improved;In Vitro;Infant;Infection;Inflammation;Inflammatory;Inflammatory Response;insight;interest;Lesion;Literature;Location;Maternal-Fetal Exchange;Measures;Mediating;Mediator;Memory;Modeling;Mucous Membrane;multidisciplinary;multiple omics;nonhuman primate;novel;Organoids;Pathologic;Pathology;Pathway interactions;Phenotype;Physiological;Placenta;Placental Biology;placental trophoblasts;Population;Positioning Attribute;Pregnancy;Premature Birth;Premature Labor;prevent;Process;Production;Publishing;rational design;Reporting;repository;Research;response;Role;Sampling;Scientist;Specimen;T memory cell;T-Cell Activation;T-cell receptor repertoire;T-Lymphocyte;targeted treatment;Techniques;Term Birth;Tissues;trophoblast;United States;Uterus;Work

PROJECT_TITLE: Function of T cells at the Maternal-Fetal Interface

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: BOCA RATON

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

PHR: NARRATIVE PTP1B, a non-receptor–type oncogenic PTP, also known as PTPN1, is involved in growth factor signaling. The PTP1B gene is frequently amplified in ovarian, gastric, prostate, and breast cancers and correlates with poor prognosis. However, despite the attractiveness of PTP1B as a therapeutic target, the development of drug-like inhibitors of this enzyme has proven difficult, primarily due to low cell permeability and a lack of selectivity towards other PTPs. The goal of this proposal is to develop charge neutral inhibitors that specifically target the oxidized form of PTP1B (PTP1B- ox), which exists principally in the disease state.

PI_NAMEs: CARROLL, KATE SUZANNE (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Acceleration;Active Sites;AKT Signaling Pathway;alpha helix;Amides;Antibodies;Antineoplastic Agents;Apoptosis;Biological Availability;Breast Epithelial Cells;Catalytic Domain;Cell Cycle Arrest;cell growth;Cell Proliferation;Cells;Cellular Assay;Charge;Chemistry;combinatorial;Disease;drug development;drug discovery;Energy Metabolism;Enzyme Inhibitor Drugs;Epithelium;ERBB2 gene;Etiology;Family;Foundations;Future;Genes;Genetic;Goals;Growth Factor;Human;human disease;Immunoglobulin Fragments;inhibitor;innovation;insight;Insulin;interest;Invaded;knock-down;Knock-out;Knockout Mice;Leptin;Libraries;Lymphomagenesis;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;malignant stomach neoplasm;Mammary Neoplasms;Mammary Tumorigenesis;MAP Kinase Gene;Mediating;member;Mesenchymal;Metabolic Diseases;Metabolism;Metastatic Neoplasm to the Lung;migration;mimetics;Molecular Conformation;Mouse Mammary Tumor Virus;mouse model;Nature;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;Oncogenic;oxidation;Oxidation-Reduction;Periodicity;Permeability;pharmacologic;PIK3CG gene;polyketides;Process;Prognosis;protein tyrosine phosphatase 1B;Proteins;PTPN1 gene;Reactive Oxygen Species;Regulation;Research Personnel;response;Role;screening;sensor;Signal Pathway;Signal Transduction;Sulfenic Acids;Therapeutic;therapeutic target;Tissues;TP53 gene;tumor;Tumor Suppressor Proteins

PROJECT_TITLE: Targeting Oxidized PTP1B for Anticancer Drug Discovery


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Complementary and Integrative Health;Data Science;Machine Learning and Artificial Intelligence;Natural Products;Networking and Information Technology R&D (NITRD)

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Natural products from bacteria, fungi, and plants have long been a rich source of therapeutically relevant molecules, but the relationship between natural product structure and activity is not fully understood, hindering our ability to further optimize natural products for therapeutic use. Machine learning can be used to develop models that explain trends in data and make predictions for new data points. In this work we will apply machine learning to understand structure-activity relationships in natural products, design biosynthetic gene clusters to improve our ability to biosynthesize natural product analogs, and repurpose natural products as protein- protein interaction inhibitors.

PI_NAMEs: WALKER, ALLISON SARA (contact)

PROJECT_TERMS: Anabolism;analog;Attention;Bacterial natural products;Behavior;Biochemical;Biological;Chemical Structure;Chemicals;Complex;Computational Technique;computerized tools;Computers;Coupling;Data;design;Directed Molecular Evolution;drug discovery;Enzymes;experimental study;fungus;Gene Cluster;gene product;Genes;genetic approach;Genetic Structures;graph neural network;high throughput screening;improved;inhibitor;interest;Machine Learning;machine learning algorithm;machine learning method;machine learning model;method development;Methods;Modeling;Molecular Machines;molecular modeling;natural product inspired;Natural Products;novel;Pathway interactions;Peptide Leader Sequences;peptide synthase;Peptides;Plants;polyketide synthase;Property;protein aminoacid sequence;protein protein interaction;Ribosomes;Source;Structure;Structure-Activity Relationship;System;Therapeutic;Therapeutic Uses;training data;trend;Work

PROJECT_TITLE: Machine learning approaches for the discovery, repurposing, and optimization of natural products with therapeutic potential


ADMINISTERING_IC: NS

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: WASHINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Multiple sclerosis (MS) is an immune-mediated neurological disorder characterized by the accumulation of lesions laden with inflammatory microglia in the central nervous system (CNS), which drive demyelination and impede the remyelination process. This project will investigate a strategy to enhance remyelination by genetically modifying microglial cells in demyelinated lesions towards a pro-regenerative state. The results of this study will advance our understanding of the immunoregulatory mechanisms governing remyelination, which could have implications for the development of pharmacological therapies aimed at improving remyelination in individuals with MS.

PI_NAMEs: HUANG, JEFFREY K (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Address;Affect;Amino Acid Transport System L;Amino Acids;Astrocytes;Axon;Cell Lineage;Cell Separation;Central Nervous System;Characteristics;Chronic;Data;Demyelinating Diseases;Demyelinations;Development;disability;disabling disease;Exhibits;Failure;FRAP1 gene;Future;Gene Expression Profile;Gene Modified;Goals;Growth Factor;IGFBP5 gene;Immune;immune activation;immunoregulation;improved;Individual;Inflammation;Inflammatory;inflammatory marker;inhibitor;Injury;innovation;Insulin-Like Growth Factor I;ITGAM gene;ITGAX gene;Lesion;loss of function;Lysophosphatidylcholines;Macrophage;Macrophage Activation;Mass Spectrum Analysis;Mediating;Metabolic;metabolic profile;Metabolism;metabolomics;Microglia;Multiple Sclerosis;Mus;Myelin;Myeloid Cells;Natural regeneration;Nervous System Disorder;novel;novel therapeutic intervention;Nuclear RNA;oligodendrocyte lineage;Oligodendroglia;pharmacologic;Pharmacotherapy;phosphoproteomics;Play;Population;Post-Translational Protein Processing;Process;Proteins;Proteomics;regenerative;regenerative therapy;Regulation;remyelination;repaired;response;Role;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Testing;Therapeutic;transcriptome sequencing;Up-Regulation

PROJECT_TITLE: Immunoregulation in CNS remyelination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-M(03)]


ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: PROJECT NARRATIVE  N6-methyladenosine (m6A) represents the most abundant internal modification of mRNA, and while we now have a reasonable understanding of the biochemical machinery that places this epitranscriptomic mark, we are still in the infancy of understanding its biological importance in vivo. Recent efforts point to the nervous system as being especially sensitive to m6A-mediated gene regulation. This project will integrate powerful genetic, genomic, biochemical, and electrophysiological tools available in the Drosophila system to determine how m6A regulates synaptic activity at the neuromuscular junction, and dissect multiple molecular mechanisms by which m6A imparts regulatory impacts in the nervous system.

PI_NAMEs: HAGHIGHI, ALI PEJMUN  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Acute;base;Behavioral;Binding;Biochemical;Biological;Biological Assay;Biology;causal variant;Collaborations;Complex;Cytoplasm;Data;Data Set;data tools;Defect;Development;developmental disease;Disease;Dissection;Drosophila genus;Electrophysiology (science);Ensure;epitranscriptome;epitranscriptomics;Exhibits;experimental study;fly;FMR1 gene;Focus Groups;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Diseases;genomic data;Genomics;in vivo;Individual;infancy;insight;Knowledge;Link;Maps;Mediating;member;Messenger RNA;Methylation;Methyltransferase;Modification;Molecular;Molecular Genetics;Molecular Profiling;Motor Neurons;mutant;Nervous System;neural;neural circuit;Neurobiology;Neurodegenerative Disorders;neuromechanism;Neuromuscular Junction;Neurons;neurotransmitter release;novel;Nuclear;Pathway interactions;Phenotype;Physiological;Positioning Attribute;posttranscriptional;Presynaptic Terminals;programs;Proteins;Reader;recruit;Regulation;Regulatory Pathway;Resolution;Role;Site;spatiotemporal;Synapses;synaptic function;System;Testing;tool;transcriptome;Translational Regulation;Translational Repression;Validation;vesicular release;Work

PROJECT_TITLE: Regulation of synaptic activity by mRNA methylation

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

PHR: PROJECT NARRATIVE Epilepsy is a significant public health issue, due to its high economic burden, increased death rate in patients, and the inadequacy of current therapeutics to control seizures in up to a third of patients. Thus, new approaches are needed for the development of innovative, more effective treatments, including preclinical models based on animals that recapitulate the complex etiology of major human epilepsy syndromes. Our study is relevant to NIH’s mission because the genetic characterization of baboon epilepsy and development of in vitro cerebral organoid systems analogous to those used in human studies provides a platform for testing of new therapies that can be easily translated using a naturally occurring primate model of epilepsy, reducing clinical attrition and improving disease outcomes.

PI_NAMEs: CARLESS, MELANIE  (contact);KOS, MARK ZLOJUTRO;SZABO, CHARLES AKOS

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Accounting;Adult;Affect;Animal Model;Animals;antagonist;Anticonvulsants;Architecture;base;Behavior;behavioral impairment;Belief;Biological;Blood - brain barrier anatomy;Brain;Brain region;brain tissue;Candidate Disease Gene;cell type;Cells;Cerebrum;Chronic;Clinical;clinical implementation;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Complement;Complex;Data;Death Rate;Development;Diagnosis;differential expression;Disease Outcome;Drug resistance;Economic Burden;effective therapy;Electroencephalography;Electrophysiology (science);epigenomics;Epilepsy;Epileptogenesis;Etiology;Excitatory Synapse;Exhibits;Future;Gene Expression;Gene Expression Profile;Generalized Epilepsy;Genes;Genetic;genetic architecture;genetic association;Genetic Transcription;genetic variant;Genome;genome sequencing;Heritability;Homologous Gene;Human;Human Genetics;Impaired cognition;improved;In Vitro;in vitro Model;in vivo;Incidence;induced pluripotent stem cell;innovation;Investigation;knockout gene;Link;Medial;MicroRNAs;Mission;Modeling;Molecular;Molecular Profiling;Morphology;mortality risk;mRNA Expression;multiple omics;Nervous System Disorder;neural model;Neuroanatomy;Neurocognitive Deficit;neuroimaging;Neurons;novel;novel strategies;novel therapeutics;Oligonucleotides;Organoids;Outcome;Papio;Partial Epilepsies;Pathway interactions;Patients;Pattern;Persons;Pharmaceutical Preparations;Physiological;Physiology;Pilot Projects;Play;pre-clinical;Pre-Clinical Model;prevent;Primates;Proteins;Proteomics;Public Health;Quality of life;Recurrence;Regulation;Regulator Genes;Reporting;Research;restoration;risk minimization;risk variant;RNA-Binding Proteins;Rodent;Rodent Model;Role;Safety;Sampling;Seizures;Sentinel;Signal Transduction;single nucleus RNA-sequencing;Structure;synaptic function;Syndrome;System;Testing;Therapeutic;therapeutic miRNA;Tonic-Clonic Epilepsy;transcriptome sequencing;transcriptomics;Translating;treatment strategy;United States National Institutes of Health;whole genome;Work

PROJECT_TITLE: Preclinical Modeling of Neural Regulatory Networks in Baboon Epilepsy

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Multiple system atrophy is a progressive neurodegenerative disorder caused by the abnormal accumulation of the protein alpha-synuclein in oligodendrocytes accompanied by inflammation and neuron loss in the brain. The treatment and development of therapeutics is limited due to a gap in knowledge of mechanisms that mediate this neurodegenerative process. The goal of this project is to investigate the contribution of brain- resident and peripheral immune cells in initiating and sustaining inflammation, and target these cells as a novel way of blocking disease progression.

PI_NAMEs: HARMS, ASHLEY N (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;alpha synuclein;Animal Model;antigen-specific T cells;Antigens;Area;ATAC-seq;Attenuated;Automobile Driving;Autonomic Dysfunction;Autopsy;B-Lymphocytes;Biological Models;Brain;CD3 Antigens;CD4 Positive T Lymphocytes;Cell Death;Cell Maturation;Cell Separation;Cells;cerebral atrophy;conditional knockout;cytokine;Data;Demyelinations;Deposition;Disease;disease model;disease phenotype;Disease Progression;Effector Cell;Functional disorder;Gene Expression Profile;Genetic;glial activation;Goals;Heterogeneity;HLA-DR Antigens;Human;human disease;Immune;immune activation;Immune response;Immune system;Immune Targeting;Immunoglobulin G;Infiltration;Inflammation;Inflammatory;Innate Immune Response;Interleukin-10;Intervention;Knowledge;Laboratory Finding;Lymphocyte;Macrophage;Mediating;Memory;Microglia;Modeling;monocyte;mouse model;multiple omics;Multiple System Atrophy;Mus;Myelogenous;Nature;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;neuron loss;novel;Oligodendroglia;Oligonucleotides;overexpression;Pathogenesis;Pathology;Pathway interactions;Patients;Peripheral;pharmacologic;Play;Population;pre-clinical;Pre-Clinical Model;Process;Production;Proteins;recruit;Reporting;Research;research study;response;Role;single-cell RNA sequencing;Source;Specificity;synucleinopathy;T cell clonality;T cell infiltration;T cell receptor repertoire sequencing;T cell response;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;therapeutic development;Therapeutic Intervention;Tissues;trafficking;transcription factor;Translating;Up-Regulation;Viral Vector;Work

PROJECT_TITLE: Mechanisms of alpha-synuclein mediated inflammation in multiple system atrophy

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative This project will investigate the mechanisms that provide the nervous system with the ability to detect cold temperatures. The studies described will determine if these stimuli are transmitted via distinct neural circuits to mediate the range of behavioral and physiological responses to cold temperatures, providing not only insights into somatosensory signaling and the mechanisms that bring about pain associated with this modality, but also potential therapeutic interventions that use cold as a stimulus.

PI_NAMEs: MCKEMY, DAVID D (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Absence of pain sensation;Acute;Afferent Neurons;allodynia;Analgesics;Behavioral;calretinin;candidate identification;cell type;Cells;Chemicals;chronic itch;chronic pain;chronic pain management;cohort;cold temperature;Complex;Cutaneous;Detection;Disease;Environment;Esthesia;Etiology;Genetic;genetic approach;glial cell-line derived neurotrophic factor;In Vitro;in vivo;Injury;innovation;insight;Interneurons;Ion Channel;Knowledge;Ligands;Mammals;Measures;Mechanics;Mediating;Menthol;Modality;Modeling;Molecular;mouse genetics;Nerve Endings;Nervous System;neural circuit;neurochemistry;Neurons;Nociception;Nociceptors;novel;Pain;pain signal;Pathologic;Peripheral;pharmacologic;Physiologic Thermoregulation;Physiological;Population;Process;Pruritus;receptor;response;sensor;Sensory;Signal Transduction;Signal Transduction Pathway;Site;Skin;somatosensory;Spinal;Spinal Cord;Spinal cord posterior horn;Stimulus;System;Temperature;Testing;Thalamic structure;Therapeutic;Therapeutic Intervention;transmission process;TRPV1 gene

PROJECT_TITLE: Molecular and cellular mechanisms of cold allodynia

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Cardiovascular;Neurosciences;Nutrition;Obesity;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: Columbus

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Thus far, it is unclear whether the underlying cause of chronic metabolic complications after SCI may be linked to adipose tissue dysfunction. Also unknown are the cellular and molecular mechanisms that cause or contribute to pathophysiological changes in white adipose tissue (WAT) after SCI. This study proposes and aims to test the hypothesis that aberrant sensory plasticity causes maladaptive changes in WAT and vascular function associated with chronic metabolic complications and insulin resistance after SCI, thereby providing novel molecular targets that can be manipulated for therapeutic gain.

PI_NAMEs: TEDESCHI, ANDREA  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Adipocytes;Adipose tissue;Afferent Neurons;Blood;Blood capillaries;Blood flow;Blood Vessels;Brown Fat;Calcitonin Gene-Related Peptide;Calcitonin-Gene Related Peptide Receptor;Calcium;Calcium Channel;Cardiometabolic Disease;cardiometabolic risk;Cardiovascular system;Cell membrane;Cells;Chronic;Clinical;Coupled;Data;density;Deposition;deprivation;Deterioration;Development;Dyslipidemias;Electrophysiology (science);energy balance;experience;experimental study;Fatty Acids;Functional disorder;gabapentin;gain of function;Gene Deletion;Genetic;Health;Heart;Homeostasis;Hypertension;Image;imaging approach;Imaging Techniques;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Injury;insight;Insulin Resistance;insulin signaling;Link;Lipids;Lipolysis;Liver;loss of function;Measures;Metabolic;Metabolism;Microcirculation;Molecular;Molecular Target;Mus;Muscle;Myocardium;Nerve;nerve supply;neuronal circuitry;Neuronal Injury;Neurons;neurotransmission;novel;Obesity;Organ;patch clamp;Pathologic;Pericytes;pharmacologic;Physiological;Play;prevent;Property;RAMP1;Role;Sensory;Skeletal Muscle;Spinal cord injury;Spinal Ganglia;Stains;Structure;Sympathetic Nervous System;Synaptic Transmission;synaptogenesis;Testing;Therapeutic;Thoracic spinal cord structure;Three-Dimensional Imaging;Tissues;trafficking;Triglycerides;Vasodilator Agents;voltage;Weight Gain

PROJECT_TITLE: Reducing adipose tissue dysfunction and metabolic complications by manipulating sensory processing after spinal cord injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: NARRATIVE Ca2+/calmodulin dependent protein kinase II (CaMKII) plays significant roles in neurons, cardiomyocytes, and oocytes. We are fascinated by the multifunctional roles CaMKII plays in human health and will interrogate this important problem using a combinatorial approach from transcriptomics to cell biology.

PI_NAMEs: STRATTON, MARGARET M (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Affect;Alternative Splicing;Biochemistry;Biological;calmodulin-dependent protein kinase II;Cardiac;Cardiac Myocytes;Cell Communication;cell type;Cells;Cellular Assay;Cellular biology;Chemicals;combinatorial;Communication;Complex;Coupled;Enzymes;Event;fascinate;Fertilization;Genes;Health;Human;Infertility;intercellular communication;interest;long term memory;Mammals;millisecond;Modification;Molecular;Molecular Conformation;Myocardial dysfunction;Nervous System Disorder;Neurons;Oocytes;Organism;Output;Physiology;Play;Production;Proteins;Regulation;RNA Splicing;Role;structural biology;Therapeutic Intervention;Transcript;transcriptomics;Variant;Work

PROJECT_TITLE: Unraveling the molecular events driven by CaMKII in Ca2+-coupled cells

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care;Telehealth

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE This randomized clinical trial tests how telehealth technology can positively affect informal caregivers and patients living with Alzheimer’s disease and related dementias. The project will gather data over time to measure the impact of our evidence-based Brain CareNotes mobile telehealth app on informal caregiver burden and patients’ behavioral and psychological symptoms of dementia, in a diverse Indiana-wide sample.

PI_NAMEs: BOUSTANI, MALAZ ;HOLDEN, RICHARD J (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: acute care;Affect;African American;Aggressive behavior;aging brain;Agitation;Alzheimer's Disease;Alzheimer's disease caregiver;Alzheimer's disease patient;Alzheimer's disease related dementia;attentional control;Behavior;Behavior Therapy;Behavioral Model;Behavioral Symptoms;Black race;Brain;brain based;Caregiver Burden;Caregivers;Caring;Clinic;Communities;Consent;cost;COVID-19;Data;Dementia;dementia care;depressive symptoms;Distress;Education;effectiveness research;Emergency department visit;Enrollment;Equipment and supply inventories;evidence base;Evidence based intervention;experience;feasibility trial;follow-up;Foundations;Funding;Goals;Health;health application;Health Technology;Hospitals;implementation research;Indiana;informal caregiver;informal support;innovation;Intervention;Intervention Studies;Long-Term Care;Marketing;Measures;Mental Depression;mobile application;mobile computing;Modeling;National Institute on Aging;neuropsychiatry;Nonpharmacologic Therapy;Pain;Patient Transfer;Patients;Pilot Projects;pilot trial;primary endpoint;primary outcome;programs;psychological symptom;Public Health;Publishing;Quality of life;Questionnaires;Race;Randomized;randomized, clinical trials;remote health care;remote intervention;remote technology;Sampling;Secure;Seminal;sex;Sleep disturbances;Source;Symptoms;systematic review;Technology;technology intervention;telehealth;Testing;therapy development;Time;United States National Institutes of Health;user centered design

PROJECT_TITLE: I-CARE 2 RCT: Mobile Telehealth to Reduce Alzheimer's-related Symptoms for Caregivers and Patients


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_DEPT: OTOLARYNGOLOGY

PHR: Falls (i) are common, (ii) directly injure or kill many Americans each year, and (iii) increase exponentially as we age. While many factors contribute to falls, we focus on vestibular degradation because new data show that age- related increases in vestibular thresholds mediate (“explain”) nearly half of age-related balance declines; related findings have led to estimates that up to 150,000 Americans might die each year due to sub-optimal vestibular function, including sub-clinical age-related vestibular declines. As crucial steps to reduce age-related falls, we propose extensive human testing designed to develop: (a) targeted vestibular screening tests by quantifying impacts of vestibular declines on age-related balance declines and falls and (b) a potential intervention designed to improve vestibular precision, which could also improve balance and reduce falls.

PI_NAMEs: MERFELD, DANIEL M (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Accidents;Accounting;Address;Adult;Age;age effect;age related;age related changes;age related decline;Aging;American;balance testing;Biological Assay;Cause of Death;Cessation of life;Clinical;Data;demographics;design;Educational Intervention;Equation;Equilibrium;Etiology;Eye;Failure;fall risk;falls;Feedback;healthy aging;Human;Impairment;improved;Individual;Injury;Intervention;Intuition;Life;Link;Measures;Mediating;Mediation;Medical Care Costs;Methods;Modeling;Modernization;National Health and Nutrition Examination Survey;Noise;novel;Odds Ratio;older adult;Participant;Perception;Perceptual learning;Peripheral;Population;Posture;Public Health;Publishing;Rehabilitation therapy;Reporting;Research;Romberg test procedure;screening;Sensory;Statistical Data Interpretation;Surveys;Testing;therapy design;Time;Training;Variant;Vestibular function;Vestibular Function Tests;vestibular system;Work;young adult

PROJECT_TITLE: Towards healthy aging: Quantifying vestibular contributors to age-related changes in balance and fall risk


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_STATE: CA

PHR: PROJECT NARRATIVE Hypertension affects half of American adults but poses an especially severe burden on African Americans. Understanding and eliminating disparities in hypertension and related social determinants of health is a national research priority identified in NHLBI’s Strategic Vision. This project will leverage unique opportunities in spatial epidemiology to quantify the fraction of hypertension disparities that can be eliminated by addressing disparities in geographic areas’ socioeconomic characteristics and structural environmental resources.

PI_NAMEs: ABDEL MAGID, HODA  (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Address;Adult;Affect;African American population;Age of Onset;American;Area;Biometry;Black Populations;Black race;Businesses;Cardiovascular Diseases;cardiovascular health;career;career development;Characteristics;cohort;Data;Data Mart;Data Sources;deprivation;Development;Diagnosis;Disparity;disparity elimination;Education;Environment;Epidemiology;ethnic minority;Ethnic Origin;Food;Geographic Locations;Geography;health disparity;Health Food;Healthcare;Housing;Hypertension;hypertension control;hypertension treatment;improved;Incidence;Income;indexing;Individual;Inequality;innovation;Intervention;Link;Location;Low income;Measures;Mediating;Medicare;Medicare/Medicaid;Methods;Modeling;multidisciplinary;National Heart, Lung, and Blood Institute;Outcome;Participant;Pathway interactions;Pattern;Population;Population Heterogeneity;Population Surveillance;Prevalence;Privatization;Process;Race;racial difference;racial disparity;racial minority;Reasons for Geographic And Racial Differences in Stroke;Recreation;Research;research and development;Research Personnel;Research Priority;residential segregation;Resources;Risk Factors;Sampling;skills;social;social health determinants;social interventions;socioeconomics;spatial epidemiology;Strategic vision;Stroke;Training;United States

PROJECT_TITLE: Leveraging Spatial Epidemiology to Reduce Hypertension Disparities


ACTIVITY: ZIA

ADMINISTERING_IC: DC

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

PI_NAMEs: CUNNINGHAM, LISA L (contact)

PROJECT_TERMS: Ablation;Address;Aging;Aminoglycoside Antibiotics;anti-cancer treatment;atorvastatin;Basic Science;biological adaptation to stress;Blood;Brain;Cell Death;Cell Survival;Cellular biology;Cellular Stress;cellular transduction;Cessation of life;Cholesterol;Cisplatin;cisplatin induced hearing loss;Clinical Research;Clinical Trials;Cochlea;Data;Databases;design;DNA Sequence Alteration;efficacy testing;Equilibrium;experience;experimental study;exposed human population;Exposure to;FDA approved;Government Agencies;Hair Cells;Head and Neck Cancer;Head Movements;Hearing;hearing impairment;hearing preservation;Hearing Protection;Hearing Tests;Heat shock proteins;Human;Incidence;intercellular communication;Knowledge;Labyrinth;Life;Lovastatin;Macrophage;Manuscripts;Mediator;Mus;nephrotoxicity;neural;noise trauma;ototoxicity;participant enrollment;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;Play;Population;pre-clinical;prevent;protein expression;Publishing;randomized placebo controlled study;rational design;Regulation;Research;Resources;response;Role;Science;Sensory;Sensory Hair;sensory mechanism;Severities;side effect;Signal Transduction;sound;Stains;Stress;Supporting Cell;Testing;Therapeutic;therapy design;therapy development;translational study;Universities

PROJECT_TITLE: Mechanisms of Sensory Hair Cell Survival and Death


ACTIVITY: ZIG

ORG_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

PI_NAMEs: MCGEHEE, JAMES  (contact)

PROJECT_TERMS: Accreditation;Anesthesia procedures;animal care;Animal Care and Use Committees;animal colony;Animal Experimentation;animal facility;Animal Husbandry;Animal Model;Animal Welfare Act;Animals;Caring;Clinical;Collaborations;Communities;Contracts;Documentation;Ensure;Equipment and supply inventories;guide for the care and use of laboratory animals;Guidelines;Housing;Injections;Institution;International;Intramural Research;Investigation;Laboratory Animals;Medical;Mission;Monitor;Mus;National Institute of Neurological Disorders and Stroke;National Institute on Deafness and Other Communication Disorders;Performance;Principal Investigator;Procedures;programs;Regulation;Research;Research Infrastructure;Research Personnel;Research Support;restraint;Review Committee;screening;Services;System;Training;United States Department of Agriculture;United States National Institutes of Health;Veterinarians;Vision

PROJECT_TITLE: NIDCD Animal Research Infrastructure


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: PROJECT NARRATIVE Interactions between the brain’s neurons and glia play important roles in normal and pathological neurological processes. Thus, gaining a better understanding the brain’s glia, and, in particular, the neuron-glia interactions, will have wide-ranging implications for human health. In this application, we describe projects to develop novel chemical tools that will enable visualization and manipulation of glia and neuron-glia interactions that will further our understanding of their roles in the brain.

PI_NAMEs: LAUGHLIN, SCOTT T. (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Activator Appliances;Anatomy;Astrocytes;Axon;blood-brain barrier penetration;Brain;Cell Physiology;cell type;Cells;Chemical Structure;chemical synthesis;Chemicals;Chemistry;Coculture Techniques;Corpus striatum structure;CRISPR/Cas technology;design;Development;Doxycycline;Drug Delivery Systems;Drug Modulation;Evaluation;experimental study;extracellular vesicles;Fishes;fluorophore;Gap Junctions;Gene Expression;Health;Hippocampus;Human;Image;in vivo;Knock-out;Label;Larva;Mediating;Microglia;Modification;Mus;Nervous System;neural;Neuroglia;Neurologic Process;Neurons;neuroregulation;Neurosciences;neurotransmission;novel;olfactory sensory neurons;oligodendrocyte progenitor;Organic Cation Transporter;Organism;Pathologic;Pharmaceutical Preparations;Physiology;Play;Population;precursor cell;Preparation;Prodrugs;Property;Rattus;Reporter;Reporting;Research;retrograde transport;Role;scaffold;Signal Transduction;Site;Slice;small molecule;Specificity;success;Synapses;Synaptic Vesicles;synaptogenesis;System;Tamoxifen;Technology;Tetracyclines;tool;Toxic effect;Transcription Coactivator;transgene expression;uptake;Visualization;Zebrafish

PROJECT_TITLE: A Chemical Strategy for Imaging and Manipulating the Brain's Astrocytes

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Osteoporosis

ORG_CITY: MINNEAPOLIS

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Osteoclasts are cells that break down bone during normal growth and repair, playing a significant role in bone destructive diseases like osteoporosis, periodontal disease, cancer, and arthritis. This project aims to determine if lysine-specific demethylase 1 (LSD1), a protein that regulates osteoclast formation by removing methyl groups from histones, inhibits osteoclast formation and activity. Understanding the molecular mechanisms governing the activity of LSD1 may lead to development of pharmaceutical treatments for diseases associated with increased bone resorption.

PI_NAMEs: ASTLEFORD-HOPPER, KRISTINA  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Acetylation;Acids;Adult;Affect;age related;American;Animal Model;Arthritis;bone;bone loss;Bone Resorption;care costs;Cell Culture Techniques;Cell Differentiation process;Cell secretion;cell type;Cells;Chemicals;ChIP-seq;Clinical;Clinical Management;cost;Cues;Data;Defect;demethylation;Dental;Dental Care;Development;Disease;DNA;drug development;Environment;Epigenetic Process;Excision;experimental study;Extracellular Matrix;Fracture;Gene Expression;Gene Expression Profile;gene repression;Gene Targeting;Genes;genetic corepressor;Genetic Transcription;Goals;Grant;Growth;Health Care Costs;Histone Acetylation;Histone Deacetylase;histone demethylase;histone modification;Histones;Hyperactivity;In Vitro;Individual;inhibitor;innovation;insight;Journals;KDM1A gene;Knowledge;Lead;Learning;Lysine;Maintenance;Malignant Neoplasms;meetings;member;methyl group;Methylation;microCT;Minerals;Minnesota;Modeling;Modification;Molecular;Morbidity - disease rate;mouse model;Multipotent Stem Cells;novel;Osteoclasts;Osteogenesis;Osteolytic;Osteoporosis;Pathologic;Pathology;Patients;Peptide Hydrolases;Periodontal Diseases;Periodontitis;Pharmacologic Substance;Phenotype;Phosphorylation;Physiology;Play;prevent;Proteins;Public Health;Regulator Genes;repaired;Repression;Research;Role;skeletal;skeletal disorder;Skeleton;small hairpin RNA;Specific qualifier value;targeted treatment;Techniques;Testing;Tissues;Tooth Loss;Training;transcription factor;transcriptome sequencing;United States;Universities

PROJECT_TITLE: The epigenetic role of LSD1 in osteoclast differentiation


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Biomedical Imaging;Data Science

PI_NAMEs: CAPRIOLI, RICHARD M (contact)

PROJECT_TERMS: 3-Dimensional;Achievement;Atlases;biocomputing;Biological;Biomedical Research;Collaborations;Communication;Communities;complex data;Data;Data Analyses;data exchange;data management;data mining;data sharing;design;development policy;experience;Eye;flexibility;Foundations;Freezing;Goals;High Performance Computing;Human;Human BioMolecular Atlas Program;human tissue;imaging facilities;Imaging technology;Infrastructure;Institution;Laboratories;large scale data;Leadership;Manuscripts;Mass Spectrum Analysis;meetings;member;Mining;Mission;Molecular;molecular imaging;multidisciplinary;Multimodal Imaging;multimodality;operation;Organ;Pancreas;Physicians;Procedures;Productivity;professional atmosphere;programs;Protocols documentation;Publications;Publishing;Reporting;Research;Research Activity;Research Personnel;Resources;Role;Sampling;Scientific Evaluation;Scientist;Site;skills;Specimen;success;Time;Tissue atlas;Tissue Banks;tissue fixing;tissue mapping;tool;Travel;United States National Institutes of Health;Universities;Visualization;Work

PROJECT_TITLE: Coordination Core


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: OVERALL PROJECT NARRATIVE Yale Cancer Center (YCC) is committed to eliminating the burden of cancer through transformative research, with attention to the needs of all people facing this disease. Our goal is to understand and prevent cancer, detect cancer early, and manage cancer more effectively, while maximizing access to care, addressing the needs of the community, ensuring equity and diversity in our workplace, and training future cancer researchers, clinicians, and leaders.

PI_NAMEs: WINER, ERIC P (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Academia;Address;anti-cancer research;Area;Attention;Award;Back;Basic Cancer Research;Basic Science;Biological Markers;Cancer Burden;cancer care;Cancer Center Support Grant;cancer health disparity;cancer prevention;cancer therapy;career development;Caring;Catchment Area;Clinic;Clinical;clinical care;Clinical Sciences;Clinical Trials;Collaborations;combat;Communities;community involvement;Connecticut;design;Diagnosis;Direct Costs;Disease;Disparity;Disparity in diagnosis;disparity reduction;Diverse Workforce;diversity and equity;Dreams;Ensure;Equity;Fostering;Funding;Future;Goals;Grant;Health Services Accessibility;Heart;Improve Access;improved;Individual;Industry;innovation;Institution;Investments;Journals;Knowledge;Laboratories;Leadership;Link;Malignant Neoplasms;member;Mentors;NCI Center for Cancer Research;next generation;novel;novel therapeutic intervention;Outcome;Output;Patient Selection;Patients;Peer Review;Persons;Physicians;Population;Population Sciences;prevent;programs;Publications;Recording of previous events;recruit;Research;Research Personnel;Resource Sharing;Resources;Role;Scientist;Screening for cancer;Services;Source;Strategic Planning;synergism;Technology;therapy resistant;Training;Training and Education;Translating;Translational Research;Universities;Vision;Work;Workplace;Yale Cancer Center

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE: OVERALL The University of Miami’s Sylvester Comprehensive Cancer Center (Sylvester), the only NCI-designated cancer center in South Florida, is a source of discovery and innovation in cancer research, effective and inclusive approaches to education and training, novel community outreach and engagement activities for the prevention, diagnosis, and treatment of cancer, and hope for residents of its uniquely diverse catchment area. Focused on catchment area-relevant research, Sylvester’s four Research Programs span the spectrum of basic, clinical, translational, and population science research to reduce the human burden from cancer in the community the center serves. Sylvester leaders, clinicians and researchers work collaboratively to create a culture and environment that advances diversity, equity, and inclusion, and uses technologically advanced and culturally sensitive approaches to develop, evaluate, and implement novel treatments and effective interventional strategies that will sustainably and favorably impact cancer outcomes in South Florida and beyond.

PI_NAMEs: NIMER, STEPHEN D. (contact)

PROJECT_TERMS: Achievement;Address;Aging;anti-cancer research;Basic Science;Biotechnology;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Etiology;cancer health disparity;Cancer Model;cancer prevention;cancer risk;cancer therapy;Catchment Area;Clinical;Clinical Oncology;Clinical Research;Clinical Sciences;collaborative environment;Communities;community center;community engagement;Community Outreach;community partners;Comprehensive Cancer Center;cost efficient;County;Cultural Backgrounds;Development;Diagnosis;Direct Costs;Education;effective intervention;Ensure;Environment;Environmental Risk Factor;Epigenetic Process;equity, diversity, and inclusion;ethnic identity;Ethnic Origin;Exclusion;Extramural Activities;Faculty;Florida;Fostering;Funding;Future;Gender Identity;Genetic;Goals;Grant;Growth;Health;health disparity;health equity;Home;Human;improved;Infection;Infrastructure;innovation;insight;Institution;Interdisciplinary Study;Intervention;investigator-initiated trial;Investments;K-Series Research Career Programs;Knowledge;Leadership;Learning;Localized Malignant Neoplasm;Malignant Neoplasms;Measurable;Medical;member;Mission;NCI-Designated Cancer Center;Neighborhoods;next generation;novel;Oncology;Outcome;outreach;Patient Care;Patient-Focused Outcomes;Patients;Peer Review;Persons;Pilot Projects;Population Sciences;Prevention;preventive intervention;Process;programs;Public Policy;Publications;Race;racial identity;recruit;Reporting;Research;Research Activity;Research Infrastructure;Research Personnel;Resource Sharing;Risk Factors;Role;Science;socioeconomic diversity;socioeconomics;Source;Strategic Planning;Technology;Therapeutic Intervention;Training;Training Activity;Training and Education;Training Programs;Translating;translational oncology;Translational Research;Tumor Biology;Universities;Work

PROJECT_TITLE: The Sylvester Cancer Center Support Grant


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PI_NAMEs: LLOYD, SCOTT  (contact)

PROGRAM_OFFICER_NAME: PTAK, KRZYSZTOF

PROJECT_TERMS: Annual Reports;anti-cancer research;Applications Grants;Award;Awareness;Basic Science;beneficiary;Budgets;Cancer Center;Cancer Center Support Grant;cancer clinical trial;career;Catchment Area;Characteristics;Clinical;Clinical Research;Clinical Trials;combat;Communication;Comprehensive Cancer Center;computer infrastructure;computer network;Computer software;cost effective;Database Management Systems;Databases;Dedications;Development;Documentation;Education;Education and Outreach;Employee;Environment;Equipment;experience;Faculty;Faculty Recruitment;faculty support;flexibility;Funding;Goals;Grant;Head;Health Service Area;Human Resources;improved;informatics shared resource;innovation;Journals;Leadership;Maintenance;Malignant Neoplasms;Marketing;Medicine;meetings;member;Mission;Monitor;National Cancer Institute;Office of Administrative Management;operation;Outcome;outreach;Patients;Pilot Projects;Policies;Population Research;Population Sciences;Positioning Attribute;Process;programs;recruit;Research;research and development;Research Institute;Research Personnel;Resource Sharing;Resources;Science;Security;service delivery;Services;software systems;Strategic Planning;Strategic vision;success;symposium;System;Telephone;trial planning;Universities;Utah;Work

PROJECT_TITLE: Cancer Center Administration


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

PROJECT_TITLE: “GLP Toxicology Study for Adjuvanted HIV-1 Immunogen Vaccine Candidates


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections

PI_NAMEs: GOEPFERT, PAUL A. (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: 2019-nCoV;Affect;Alabama;antiretroviral therapy;Area;Award;Basic Science;bench to bedside;career;career development;Clinical;Clinical Research;Clinical Sciences;cohort;Collaborations;Communities;community building;community engaged research;community engagement;community partners;COVID-19 pandemic;Development;Educational workshop;Emerging infection;Environment;Epidemic;Extramural Activities;Faculty;Financial Support;Fostering;Funding;Funding Opportunities;graduate student;Grant;Height;HIV;HIV diagnosis;HIV/STD;implementation science;innovation;interest;investigator training;Investments;Laboratories;Learning;Mentors;Mentorship;Methods;Mission;next generation;novel;Pathogenesis;Persons;Positioning Attribute;preference;Prevention;Process;Program Development;programs;public health emergency;Recording of previous events;recruit;Research;Research Personnel;Research Priority;Research Support;response;Science;Scientist;skills;Strategic Planning;Structure;Students;success;syndemic;synergism;Testing;Time;Training;treatment optimization;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;virology;Woman;Work;working group;Writing

PROJECT_TITLE: Developmental Core (Core B)


PROJECT_TERMS: 2019-nCoV;Affect;Alabama;antiretroviral therapy;Area;Award;Basic Science;bench to bedside;career;career development;Clinical;Clinical Research;Clinical Sciences;cohort;Collaborations;Communities;community building;community engaged research;community engagement;community partners;COVID-19 pandemic;Development;Educational workshop;Emerging infection;Environment;Epidemic;Extramural Activities;Faculty;Financial Support;Fostering;Funding;Funding Opportunities;graduate student;Grant;Height;HIV;HIV diagnosis;implementation science;innovation;interest;investigator training;Investments;Laboratories;Learning;Mentors;Mentorship;Methods;Mission;next generation;novel;Pathogenesis;Persons;Positioning Attribute;Prevention;Process;Program Development;programs;public health emergency;Recording of previous events;recruit;Research;Research Personnel;Research Priority;Research Support;response;Science;Scientist;skills;Strategic Planning;Structure;success;synergism;Time;Training;treatment optimization;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;virology;Woman;Work;working group;Writing


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

PI_NAMEs: EATON, ELLEN FLORENCE (contact)

PROJECT_TERMS: Acceleration;Accident and Emergency department;addiction;Address;Adopted;Affect;AIDS prevention;Alabama;anti-racism;antiretroviral therapy;Beds;career;Chemicals;Clinic;Clinical;clinical care;cohort;Collaborations;Communities;community advisory board;community engagement;Community Health;community organizations;community partners;community partnership;comorbidity;County;Dedications;Deep South;Developing Countries;Development;Diagnosis;Disparity;Drug user;early-career faculty;Educational workshop;Epidemic;Epidemiologic Factors;Epidemiologic Methods;ethnic minority population;experience;Extramural Activities;Faculty;Faith;Feedback;Focus Groups;Fostering;Funding;Growth;Harm Reduction;Health;Health behavior;health equity;Health equity research;Health system;Healthcare;Hepatitis C;HIV;HIV disparities;HIV risk;Hospitals;Individual;Injecting drug user;innovation;Institutional Racism;Learning;Legal;Lived experience;Maps;marginalized population;member;Mentors;Needle Sharing;Needs Assessment;Opioid;opioid epidemic;Outcome;Overdose;Persons;Pharmaceutical Preparations;Population;posters;programs;Prostitution;Public Health;racial minority population;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Risk;Risk Behaviors;rural area;Science;Scientist;sex;Sexually Transmitted Diseases;social health determinants;Social Justice;Social Sciences;social stigma;Structure;substance use;Substance Use Disorder;symposium;Training;training opportunity;Translating;transmission process;underserved area;Underserved Population;vulnerable community;Work;working group

PROJECT_TITLE: Substance Use SWG


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Infectious Diseases;Prevention

PI_NAMEs: HEFFRON, RENEE A. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Advisory Committees;Alabama;Area;base;billboard;Clinical;Collaborations;Communication;Communities;community organizations;Community Outreach;community partners;community science;Development;Educational workshop;Effectiveness;Electronic Mail;Electronics;Ensure;Environment;equity, diversity, and inclusion;Event;Feedback;Financial Support;Fostering;Funding;Future;global health;Growth;Harm Reduction;HIV;implementation science;Individual;innovation;Interdisciplinary Study;interest;Leadership;meetings;member;Mission;Monitor;multidisciplinary;next generation;organizational structure;Outcome Measure;Periodicals;Persons;Play;Process;recruit;Research;Research Personnel;Research Priority;Research Project Grants;Role;Services;sex;social media;Strategic Planning;Structure;substance use;symposium;syndemic;synergism;System;Technology;timeline;tool;Training;Training and Education;training opportunity;United States National Institutes of Health;Universities;web site;Work;working group

PROJECT_TITLE: Administrative Core (Core A)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: SAN FRANCISCO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The central research mission of our lab is to uncover the core principles underlying the assembly heterochromatin, a central gene-repressive element in the genome. Heterochromatin assembly heritably partitions the genome into active and inactive regions and in its normal state, this process drives cellular differentiation, while when misregulated, underlies a variety of diseases, including several cancers. We propose an integrative approach to define central cellular and biochemical mechanisms of dynamic heterochromatin assembly, ranging from single molecule biophysical to real-time single-cell measurements, which will reveal crucial intervention points for tuning this reaction in disease treatment, regenerative medicine, and synthetic biology.

PI_NAMEs: AL-SADY, BASSEM  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Behavior;Biochemical;Biophysics;Cell Differentiation process;Cells;Chemicals;Chromatin;Contracts;Development;Disease;DNA Sequence;Elements;Environment;Epigenetic Process;Fission Yeast;gene repression;Genes;Genetic;Genome;Heritability;Heterochromatin;histone methylation;Histones;Individual;Intervention;Laboratories;Lysine;Malignant Neoplasms;Measurement;Methods;Methylation;Methyltransferase;Mission;Modeling;Molecular;Molecular Machines;Multienzyme Complexes;Nuclear;Pattern;preservation;Process;Reaction;Recording of previous events;Regenerative Medicine;Research;sensor;Signal Transduction;single molecule;stem cells;synthetic biology;System;Time;Writing

PROJECT_TITLE: Tracking how molecular machines propagate epigenetic information in time and space

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: NARRATIVE Triple-negative breast cancer is the most lethal form of breast cancer, and currently, it has no approved targeted therapy. Our research will establish a novel therapeutic strategy to target the interorganelle communications in MYC-driven TNBC and improve patient outcome.

PI_NAMEs: CHEN, XI  (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: Applications Grants;Binding;Biological;biological adaptation to stress;Breast Cancer Cell;Breast Cancer Patient;breast cancer progression;cancer cell;cancer subtypes;Carnitine;cell behavior;Cell Nucleus;Cell Physiology;Cells;Cellular Stress;chemotherapy;cohort;Combined Modality Therapy;Communication;Consumption;Data;Dependence;Development;docetaxel;Endoplasmic Reticulum;endoplasmic reticulum stress;Energy Metabolism;Enhancers;Enzymes;fatty acid oxidation;Fatty Acids;Functional disorder;Genetic Transcription;Genetically Engineered Mouse;Goals;Growth;immunogenic cell death;Impairment;improved;In Vitro;in vivo;inhibitor;insight;long chain fatty acid;Malignant Breast Neoplasm;Mediating;Membrane;Metabolic;Metabolic Pathway;Mitochondria;Molecular;mortality;novel;novel therapeutic intervention;Oncogenes;Oncogenic;Organelles;overexpression;parent grant;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;pharmacologic;Pilot Projects;pre-clinical;Predisposition;Production;programs;promoter;Proteins;Relapse;relapse prevention;Research;Resistance;response;restraint;Ribonucleases;Role;sensor;Specificity;Stress;Swelling;synthetic lethal interaction;Systemic Therapy;targeted treatment;Testing;Therapeutic;therapy resistant;Toxic effect;Transferase;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;tumor eradication;tumor growth;tumor metabolism;tumor xenograft;tumorigenesis;Update;uptake;XBP1 gene

PROJECT_TITLE: Crosstalk Between the ER Stress Response and Mitochondrial Fatty Acid Oxidation in MYC-driven Breast Cancer


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Rehabilitation;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: PSYCHOLOGY

PHR: Project Narrative Impairment of information processing is a frequent consequence of stroke. Several interventions have been developed to address this impairment but the transfer of gains made in the treatment setting to everyday life and the retention of these gains is limited. The proposed research is designed to begin the process of evaluating a Transfer Package of behavioral techniques designed to result in: 1) transfer of gains achieved in the treatment setting to everyday life, and 2) result in retention of the real-world gains without decrement for at least 1 year.

PI_NAMEs: BALL, KARLENE K;USWATTE, GITENDRA  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Adult;Affect;Aftercare;arm;Automobile Driving;Basic Science;Behavioral;blood oxygenation level dependent response;care costs;Caregivers;caregiving;Caring;chronic stroke;Cognition;Cognitive;cognitive ability;Cognitive deficits;cognitive function;cognitive rehabilitation;cognitive task;Communities;cost;Data;Dementia;design;Disease;driving performance;Elderly;Evaluation;Exhibits;experience;Family member;follow-up;functional improvement;Impaired cognition;Impairment;improved;Individual;information processing;instrumental activity of daily living;Intervention;Laboratories;Life;Measurement;Measures;Methods;Modeling;Motor;Movement;new combination therapies;novel;Outcome;Participant;Patient Care;Patients;Performance;Persons;post stroke;post stroke cognitive impairment;Prevalence;Procedures;Process;processing speed;Quality of life;Randomized, Controlled Trials;Rehabilitation therapy;Research;Research Personnel;Research Proposals;Sample Size;Sampling;Savings;Signal Transduction;Site;Speed;Stroke;stroke patient;Task Performances;Techniques;Testing;therapy design;Training;treatment effect;Work

PROJECT_TITLE: Transferring Speed of Processing Gains to Everyday Cognitive Tasks after Stroke

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


PI_NAMEs: RICHIE, ELLEN R (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE This supplement proposal is designed to address specific gaps in resources and staffing needed to meet key objectives of the HEALthy Brain and Child Development (HBCD) Study in the current funding cycle. The specific needs that will be filled by this proposal are expansion, careful evaluation, and improvement of the Study Navigator Program; improved efficiency and oversight of the Spanish Language and Culture component of the study; and resources targeted to strategically support recruitment opportunities at HBCD sites to meet and accelerate progress toward recruitment objectives. The aims of this proposal will be carried out by the HBCD Administrative Core.

PI_NAMEs: CHAMBERS, CHRISTINA  (contact);NELSON, CHARLES ALEXANDER

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Area;Brain;Characteristics;Child Development;Collaborations;Competence;data structure;Dedications;demographics;design;effectiveness evaluation;effectiveness study;Enrollment;Ensure;Equity;Evaluation;Faculty;faculty support;field study;follow-up;Foundations;Funding;Funding Opportunities;Future;future implementation;Goals;Helping to End Addiction Long-term;improved;Individual;Institutional Review Boards;Language;Leadership;literacy;meetings;Monitor;novel;operation;Opiate Addiction;Opioid;opioid misuse;Participant;participant retention;Performance;Phase;Process;Program Evaluation;programs;Protocols documentation;Public Health;Recommendation;recruit;Research;Research Personnel;research study;Resources;Sampling;Services;Site;Site Visit;Spanish;Speed;success;Time;Training;Translating;Translations;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: The Healthy Brain and Child Development National Consortium Administrative Core