NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: COLUMBIA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The essential metal iron is critical for the survival of organisms ranging from microbes to humans. Likewise, all aerobic organisms rely on anti-oxidant systems and redox control pathways to combat oxidative stress caused by reactive oxygen species. This proposal aims to study the intersection of iron and redox regulation pathways in single-celled yeast that share similarities with human cells as well as pathogenic yeast that cause common fungal infections.

PI_NAMEs: OUTTEN, CARYN E (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: absorption;Aerobic;Affinity;Antioxidants;Binding;Binding Proteins;Biochemical;Biochemical Pathway;Biogenesis;Biological Availability;biophysical analysis;biophysical techniques;Candida albicans;Candida glabrata;cell injury;Cells;Cellular biology;cofactor;combat;Communication;Coupled;Cysteine;design;Disulfides;DNA Binding;DNA-Protein Interaction;Environment;Enzymes;Equilibrium;Fission Yeast;fungus;Genetic;glutaredoxin;Glutathione;Glutathione Disulfide;Glutathione Metabolism Pathway;Goals;Homeostasis;Homologous Gene;Human;Impairment;In Vitro;in vivo;innovation;Interdisciplinary Study;Iron;iron metabolism;Ligation;Measurement;Measures;Metabolism;metal metabolism;Metals;Microbe;Molecular;Molecular Genetics;Monitor;Mycoses;Organism;Oxidation-Reduction;Oxidative Stress;Pathogenicity;Pathway interactions;Peptides;Population;programs;Property;protein function;Proteins;Reaction;Reactive Oxygen Species;Regulation;Repression;response;Role;Saccharomyces cerevisiae;sensor;Signal Transduction;Spectrum Analysis;Sulfhydryl Compounds;Sulfur;System;Techniques;Testing;trafficking;transcription factor;uptake;Work;X-Ray Crystallography;Yeasts

PROJECT_TITLE: Mechanisms of Fungal Iron Regulation and Thiol Redox Metabolism

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Services;Physical Activity;Prevention;Sleep Research;Wound Healing and Care

ORG_CITY: Los Angeles

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SURGERY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE People with diabetes often develop neuropathic diabetic foot ulcers (DFU) which are costly to treat, impair mobility and general well-being, and often turn into chronic wounds that can eventually result in amputation and increased mortality. This study aims to reduce the burden of limb-threatening and life-limiting DFU via advancing the science in offloading adherence and smart management of the magnitude of physical activity (PA) in people with active DFU. This will be done using an innovative and interactive protective offloading device, mobile health, and positive adherence reinforcement in the context of a hypothesis driven clinical trial.

PI_NAMEs: ARMSTRONG, DAVID GEORGE (contact);NAJAFI, BIJAN

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acceleration;Address;Adherence;Amputation;Ankle;ankle joint;appropriate dose;arm;Cellular Phone;Chronic;chronic wound;Clinic;Clinical;Clinical Management;Clinical Trials;comparative;comparative effectiveness study;Complex;Complications of Diabetes Mellitus;Control Groups;cost;Counseling;Data;deconditioning;Devices;diabetes management;Diabetes Mellitus;diabetic;Diabetic Foot;Diabetic Foot Ulcer;disability burden;dosage;Enrollment;Exercise;Feedback;foot;Foot Ulcer;frailty;group intervention;healing;Health Care Costs;Immobilization;Impaired healing;Impaired wound healing;improved;improved mobility;innovation;Leg;Life;Limb structure;Lower Extremity;Measures;mHealth;Mobility decline;Monitor;mortality;Muscle;Muscular Atrophy;Nature;Neuropathy;new technology;Notification;Outcome;Pain;Participant;Patient Compliance;patient mobility;Patient-Focused Outcomes;Patients;Performance;Personal Satisfaction;Persons;Physical activity;Polysomnography;poor sleep;pressure;prevent;Prevention;Psychological reinforcement;Randomized;Recurrence;remote patient monitoring;Reporting;Research;Science;sensor;Sleep;sleep quality;smart watch;Speed;standard care;Syndrome;Time;treatment arm;treatment as usual;Treatment Cost;Ulcer;walker;Walking;Weight-Bearing state;World Health Organization;wound;wound healing

PROJECT_TITLE: Improving the science of adherence reinforcement and safe mobility in people with diabetic foot ulcers using smart offloading

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Epilepsy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Mutations in the human KIF1A gene case a novel, rare neurological disease termed KAND. This proposal is to develop tools for gathering information on patients worldwide, determine how mutations identified in KIF1A cause neurodegenerative and brain developmental defects, and test novel therapeutic strategies in rat and mouse models.

PI_NAMEs: CHUNG, WENDY K;GENNERICH, ARNE ;VALLEE, RICHARD BERT (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Adult;Affect;Age;Agonist;associated symptom;Atrophic;autosome;Axonal Transport;Behavior;Behavioral;Binding;Biological Assay;Biomechanics;Biophysics;blood-brain barrier crossing;Brain;Brain-Derived Neurotrophic Factor;Cerebral Palsy;Cerebrum;Child;Clinical;Clinical Data;clinical diagnosis;clinical phenotype;cognitive function;college;Computing Methodologies;Databases;Defect;Development;Diagnosis;Dimerization;Disease;Disease Progression;dominant genetic mutation;Embryonic Development;Epilepsy;falls;Functional disorder;gain of function;gene function;Genes;Genetic Diseases;genetic testing;Genotype;Goals;Hereditary Spastic Paraplegia;Human;human disease;Human Genetics;Impaired cognition;in vivo;Individual;individual patient;information gathering;Inherited;insight;Intellectual functioning disability;Intervention;Kinesin;Leg;Mediating;Medical Genetics;medical schools;Medicine;Microtubules;migration;mimetics;model organism;Modeling;Molecular;Motor;mouse model;Mus;mutant;mutant mouse model;Mutant Strains Mice;Mutation;N-terminal;Natural History;Nerve Degeneration;Nerve Growth Factor Receptors;nervous system development;Nervous System Disorder;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Disorder;Neurologic;neuron development;Neurons;neuropathology;neurotrophic factor;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Optic Nerve;Outcome;Pathogenesis;Pathogenicity;Patients;Peripheral Nervous System Diseases;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;polypeptide;Prognosis;Property;Proteins;Quality of life;rare condition;Rare Diseases;Rattus;Reagent;Recombinants;Rodent Model;Role;Seizures;Severities;single molecule;Site;small molecule;Spastic Paraplegia;Specialist;Structure;Symptoms;Syndrome;targeted treatment;Testing;Therapeutic Agents;therapeutic candidate;Therapeutic Intervention;therapeutically effective;tool;United States;Universities;vesicle transport;Vision

PROJECT_TITLE: Role of the Kinesin KIF1A in Neurological Disease

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Infectious Diseases;Prevention;Wound Healing and Care

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Corneal ulcer is a major cause of blindness and visual impairment worldwide. We aim to provide accurate and rapid corneal ulcer diagnosis with our innovative imaging approach, Portable In vivo Confocal Ophthalmoscopy (PICO). PICO will non-invasively visualize causative organisms of corneal ulcer and enable correct treatment without delay.

PI_NAMEs: KANG, DONGKYUN  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acanthamoeba;accurate diagnosis;accurate diagnostics;Address;Adoption;Agreement;Animals;Arizona;Biological Testing;Blindness;case-based;Cattle;cellular imaging;Cellular Phone;Clinic Visits;Clinical;clinical diagnosis;clinical examination;Collaborations;Consumption;Cornea;Corneal Diseases;Corneal Ulcer;cost;Custom;Data;Devices;Diabetes Mellitus;Diagnosis;diagnostic accuracy;Diagnostic Procedure;Diagnostic Sensitivity;diagnostic strategy;Dry Eye Syndromes;Early Diagnosis;Endothelium;Engineering;Epidemic;Equipment;Evaluation;experience;Family suidae;fungus;Goals;health care settings;high resolution imaging;Histology;Hospitals;human imaging;Image;imaging approach;Imaging Device;Imaging Techniques;in vivo;Infection;innovation;invention;Lasers;lens;Light;Methods;microscopic imaging;Modeling;Monitor;Nerve;novel strategies;Ophthalmologist;Ophthalmology;Ophthalmoscopes;Ophthalmoscopy;Optics;Organism;Outcome;Parasites;Parkinson Disease;Patients;Perforation;Performance;Peripheral Nervous System Diseases;Persons;portability;prevent;Prospective Studies;prototype;rapid diagnosis;Rapid diagnostics;Reference Standards;reflectance confocal microscopy;Reporting;Research;Resolution;Resources;Risk;Scanning;Sensitivity and Specificity;sensor;Skin;skin lesion;Source;Specificity;Speed;Strategic Planning;Technology;Test Result;Testing;Time;Tissues;Uganda;Ulcer;Universities;usability;Visual impairment;Visualization

PROJECT_TITLE: Portable In vivo Confocal Ophthalmoscope (PICO) for Accurate and Rapid Diagnosis of Corneal Ulcer


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: JOHNSON CITY

ORG_DEPT: BIOLOGY

ORG_NAME: EAST TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative C-reactive protein (CRP) is a component of the inflammatory response. CRP functions as an anti-microbial molecule against Streptococcus pneumoniae infection in mice. Our goal is to define how CRP, directly or indirectly, acts on the bacterial surface to kill them and protects mice against infection. Successful completion of this project will reveal how the properties of CRP can be utilized to develop a treatment strategy for pneumococcal infection in humans. In addition, the investigation of CRP-complement factor H interactions proposed in this project may also have implications in other areas of clinical medicine, such as age-related macular degeneration and retinal inflammation.

PI_NAMEs: SINGH, SANJAY KUMAR (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acute-Phase Proteins;Age related macular degeneration;Animal Model;antimicrobial;Area;Bacteremia;Binding;Binding Proteins;Blood;C-reactive protein;Cell Wall;Classical Complement Pathway;Clinical Medicine;Complement;Complement 1q;Complement 2;Complement Activation;Complement Factor H;Complement Inactivators;complement system;Complex;Development;Gene Proteins;Goals;Human;Immobilization;In Vitro;in vivo;Infection;Inflammation;Inflammatory Response;insight;Investigation;Knock-out;Knockout Mice;Ligand Binding;Ligands;Mediating;Modeling;mouse model;Mus;mutant;Names;Natural Immunity;Pathway interactions;Patients;Phosphorylcholine;Plasma Proteins;Pneumococcal Infections;Polysaccharides;Property;protective effect;protein function;Proteins;recruit;Retina;Role;Serum;Streptococcus pneumoniae;Structure;Surface;Testing;Time;treatment strategy;Work

PROJECT_TITLE: Complement-mediated anti-pneumococcal functions of C-reactive protein

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE A three-dimensional, vascular-network containing `skin-on-chip' system provides an alternative and low-cost in vitro platform for understanding new insights in host-viral interactions during human herpes simplex virus infection and for developing innovative therapeutics. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: ZHU, JIA  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Animal Model;Anti-viral Response;Antigenic Diversity;Antigenic Specificity;Architecture;Autologous;Biological;Biological Models;Biomedical Engineering;Biomimetics;Biopsy;Blood;Blood Vessels;Blood Volume;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Compartmentation;Cell Culture System;Cell Density;cell dimension;Cell model;Cells;chemokine;Clinical Trials;Communicable Diseases;Complex;Containment;cost;data modeling;Dermis;Development;Devices;Disease;disease model;drug candidate;drug development;drug efficacy;efficacy testing;Elements;Endothelium;Engineering;Epidermis;Event;Failure;Fibroblasts;Fluorescent in Situ Hybridization;Functional disorder;Gene Expression Profiling;genetic signature;genital herpes;Genitalia;Goals;Health;Herpes Simplex Infections;Herpes Simplex Virus Vaccines;Herpesviridae Infections;Herpesvirus 1;Homing;Host Defense;Human;Human body;human disease;Human Engineering;Human Herpesvirus 2;human model;human tissue;Immune;immune activation;Immune response;Immunity;Immunocompetent;Immunologic Surveillance;Immunologics;In Vitro;in vitro Model;in vivo;Individual;Infection;Infectious Skin Diseases;innovation;insight;Investigation;keratinocyte;Kinetics;Knowledge;Lesion;Marketing;Mediating;Medical;medication safety;Memory;Microfluidic Microchips;model design;Modeling;Molecular;Mucous Membrane;Mus;Oral;Organ;Organ Model;pathogen;Patients;Penetration;Perfusion;pharmacologic;Phase;Phase III Clinical Trials;Physiological;Population;Preclinical Testing;Predictive Value;Predisposition;Prevalence;Process;research and development;response;Signal Pathway;Simplexvirus;Skin;skin disorder;Skin Tissue;Structure;subcutaneous;Surface;System;T-Lymphocyte;Therapeutic;Therapeutic Agents;Tissue Model;tissue resident memory T cell;Tissues;Topical application;Ulcer;Vaccines;Vascularization;Viral;Virus;Virus Diseases;virus identification

PROJECT_TITLE: Modeling of human HSV infection: development of immune-competent 3D skin-on-chip with vascular perfusion

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: MENANDS

ORG_NAME: WADSWORTH CENTER

PHR: NARRATIVE Work from my group and others has shown that the textbook view of bacterial genomes is incorrect. We will leverage my expertise in genetics, genomics, and molecular biology, to continue productive lines of research on four overlapping topics that relate to the major research focus of my group: the unexpected complexity of bacterial genomes.

PI_NAMEs: WADE, JOSEPH THOMAS (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;antitermination;attenuation;Bacterial Genome;Binding;Binding Sites;Cells;Code;Complex;Data;DNA Sequence;DNA-Directed RNA Polymerase;Escherichia coli;Event;fitness;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genomics;in vivo;Individual;Intercistronic Region;interest;Maps;Messenger RNA;Molecular Biology;Open Reading Frames;Operon;Paper;premature;Process;Productivity;promoter;Proteins;Regulation;Research;rho;Rho Factor;Ribosomal RNA;RNA;Role;Site;termination factor;Textbooks;transcription factor;Transcription Initiation;transcription termination;Transfer RNA;Untranslated RNA;Work

PROJECT_TITLE: Unexpected complexity in bacterial genomes

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Contraception/Reproduction;Dementia;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

ORG_STATE: PA

PHR: Project Narrative Preeclampsia, a pregnancy-specific disorder characterized by hypertension and placental small vessel disease (SVD), is emerging as a sex-specific risk factor for dementia later in life; reasons for this elevated risk are unknown, and prevention or treatments are unavailable. We propose preeclampsia with placental SVD predicts higher probability of cerebral SVD and impaired cognition in midlife, independent of cardiovascular factors.

PI_NAMEs: CATOV, JANET M (contact);ROSANO, CATERINA

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acute;Affect;Age;Alzheimer's Disease;angiogenesis;Area;Beds;Benefits and Risks;Bioinformatics;Biological Markers;Blood;Blood flow;Blood Vessels;blood-based biomarker;Brain;Cardiac;cardiometabolism;cardiovascular risk factor;Cardiovascular system;Cerebral small vessel disease;cerebrovascular;Cerebrovascular Circulation;cerebrovascular reactivity;Cerebrum;Chronic;circulating biomarkers;Clinical Trials;Cognition;Cognitive;cognitive function;cognitive performance;cohort;Data;Decidua Basalis;Dementia;dementia risk;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;Early Intervention;Endoglin;Enrollment;Epidemiology;Etiology;executive function;Exposure to;Future;Genotype;gray matter;Health;high risk population;human old age (65+);Hypertension;Hypoxia;Impaired cognition;Inflammation;information processing;Life;Life Style;Machine Learning;Measures;Microvascular Dysfunction;middle age;Midlife women;Monitor;multidisciplinary;multimodal neuroimaging;neural;Neurocognitive;neuroimaging;Neurologic;older women;Outcome;Pathology;Patient Self-Report;Phenotype;Pilot Projects;Placenta;Positioning Attribute;post pregnancy;Pre-Eclampsia;Pregnancy;Pregnancy Outcome;Prevention;primary outcome;Probability;Process;processing speed;Protocols documentation;Race;racial diversity;Recording of previous events;Reperfusion Injury;Rest;Risk;Risk Assessment;Risk Factors;Risk Management;risk stratification;sex;Spiral Artery of the Endometrium;Standardization;statistics;Techniques;Testing;Time;vascular bed;vascular cognitive impairment and dementia;White Matter Hyperintensity;Woman;young woman

PROJECT_TITLE: Preeclampsia and the Brain: Small vessel disease and cognitive function in early midlife


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Acute care utilization contributes substantially to the cost of healthcare for Veterans. Homelessness is a robust social determinant of super utilization of acute care. Data analytics offer a means of targeting and tailoring care for the highest-need homeless Veterans; however, analytics alone are insufficient for facilitating these Veterans’ engagement in supportive services that can reduce acute care utilization. Peer Specialists trained in Whole Health Coaching (PS-WHC) is a high-value, patient-centered approach to care that can enhance homeless Veterans’ engagement in supportive services and, in turn, reduce their frequent use of acute care. By integrating data analytics with PS-WHC, our proposed research will test whether this innovative model of care reduces homeless Veterans’ reliance on acute care services. If successful, these efforts can better target and tailor care to the homeless Veterans at highest risk of poor health outcomes and premature mortality, as well as minimize the financial burden these patients exert on the care system.

PI_NAMEs: BLONIGEN, DANIEL MICHAEL (contact)

PROJECT_TERMS: Academy;acute care;Algorithms;Ambulatory Care;Appointment;budget impact;care costs;care systems;Caring;Chronic;Clinical;Communities;comorbidity;Complex;Consolidated Framework for Implementation Research;cost;dashboard;Data;Data Analytics;data integration;Development;Disease Management;effectiveness/implementation hybrid;Emergency medical service;Fees;Financial Hardship;Future;Goals;Health;Health Care Costs;health goals;Healthcare;Healthcare Systems;high risk;Homelessness;Hospitalization;Housing;hybrid type 1 design;implementation trial;informant;Informatics;innovation;inpatient service;Intervention;Interview;Link;Lived experience;Mediating;Medical;Medicine;Mental disorders;Mental Health;Methodology;Modeling;Outcome;patient navigation;patient oriented;Patient-Centered Care;Patients;peer;Personal Satisfaction;physical conditioning;Pilot Projects;poor health outcome;prediction algorithm;Premature Mortality;Primary Care;primary care practice;primary care services;primary outcome;Process;process evaluation;programs;psychosocial rehabilitation;Quality of Care;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Registries;Reporting;Research;Research Priority;Resources;Risk;Risk Reduction;Role;Services;Site;social determinants;social stigma;Specialist;Structure;substance use;suicidal risk;Suicide prevention;Testing;Text;Text Messaging;Time;Traction;Training;treatment as usual;Veterans;Vocation;whole health;Work

PROJECT_TITLE: Using Data Analytics and Targeted Whole Health Coaching to Reduce Frequent Utilization of Acute Care among Homeless Veterans

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE We have determined that vascular cells in the heart are critical to heart regeneration in neonatal mice and zebrafish. This proposal seeks to define the mechanisms that vascular cells use to promote cardiac growth. Our work can inform methods for therapeutic heart regeneration, which can be used to treat human cardiovascular diseases including heart failure.

PI_NAMEs: KARRA, RAVI  (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Adult;Angiogenic Factor;Biological Assay;Blood Vessels;Cardiac;Cardiac Myocytes;cardiac regeneration;Cardiovascular Diseases;Cell Count;Cell Cycle;Cell Proliferation;cell type;Cells;chromatin remodeling;Chromatin Remodeling Factor;Coupled;Data;Defect;Development;Endothelial Cells;Epigenetic Process;experimental study;Genes;Genetic;Goals;Growth;Growth Factor;Heart;Heart failure;Histologic;histone methyltransferase;Human;Hyperplasia;improved;In Vitro;in vivo;Knowledge;Licensing Factor;Life;life span;Link;LoxP-flanked allele;Maps;Mediating;Mediator;Methods;Mitogens;Modeling;Mus;Myocardial;Natural regeneration;Neonatal;neonatal mice;neonatal period;Outcome;overexpression;paracrine;Phenotype;Population;postnatal;Proliferating;receptor;response;Role;single cell ATAC-seq;single-cell RNA sequencing;spatiotemporal;Therapeutic;therapeutic target;Up-Regulation;Vascular Endothelial Growth Factors;VEGFA gene;Work;Zebrafish

PROJECT_TITLE: Myovascular Mechanisms of Cardiac Growth and Regeneration

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Cardiovascular;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Mental Health;Neurosciences;Pain Research;Patient Safety;Prevention;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative The proposed study is high impact and relevant to public health because it aims to investigate the effect of IV acetaminophen in the immediate postoperative period for the prevention of delirium and long term cognitive dysfunction, two of the most common and devastating complications of cardiac surgery in older adults. We will accomplish this by conducting a large scale randomized controlled trial enrolling 900 patients undergoing cardiac surgery at seven centers nationwide. Through the collection of necessary biospecimens that will be shared with NIA, this study also aims to better understand the biological mechanisms behind delirium and cognitive dysfunction, and the potential impact of IV acetaminophen on these mechanisms, thereby yielding findings of both clinical and biological importance.

PI_NAMEs: MARCANTONIO, EDWARD R;SUBRAMANIAM, BALACHUNDHAR  (contact);TALMOR, DANIEL STUART

PROJECT_TERMS: Absence of pain sensation;Acetaminophen;active method;Acute Disease;Address;Adoption;Age Years;aging population;American;Analgesics;Anesthetics;Attention;bench to bedside;biobank;Biological;Biological Availability;blind;Blood;Blood brain barrier dysfunction;Breathing;Cardiac Surgery procedures;Central Nervous System;Clinical;clinical trial enrollment;Cognition;Cognitive;cognitive function;cognitive testing;Collection;Complication;confusion assessment method;Coughing;daily pain;Delirium;Development;DNA;Etiology;Exertion;functional decline;functional status;Future;Geriatrics;Hospitals;Hour;Impaired cognition;improved;Incidence;Inflammation;Inflammation Mediators;Injury;innovation;instrumental activity of daily living;Intensive Care Units;interest;Intervention;Intravenous;intravenous administration;Length of Stay;Measures;Medical;Methods;Modality;modifiable risk;Morbidity - disease rate;mortality;Multicenter Trials;multimodality;National Institute on Aging;neuroinflammation;older adult;older patient;Operative Surgical Procedures;Opioid;Opioid Analgesics;opioid use;Outcome;Outcome Study;Pain;Pain management;pain score;Participant;patient subsets;Patients;Perioperative;Peripheral;Pharmaceutical Preparations;pharmacologic;Physical Function;Physiological;pilot trial;Placebo Control;Plasma;Population;post intervention;post-operative cognitive dysfunction;postoperative delirium;Postoperative Pain;Postoperative Period;postoperative recovery;prevent;Prevention;preventive intervention;Property;prophylactic;Public Health;Randomized;Randomized, Controlled Trials;Recovery of Function;Reporting;Research;Research Personnel;Resources;response;Rest;Risk;Risk Factors;Role;Sampling;Schedule;Scoring Method;Sedation procedure;Self Care;Severities;Societies;Specimen;stressor;symposium;Telephone;Therapeutic Intervention;therapeutically effective;Time;treatment arm;trial enrollment;Vulnerable Populations;Work

PROJECT_TITLE: Scheduled Prophylactic 6-hourly IV Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Tuberculosis causes 1.4 million deaths annually despite the availability of antibiotics and vaccination, underscoring the urgent need to improve on existing therapies. These studies seek to characterize how Mycobacterium tuberculosis affects the trafficking and function of T cells, which are crucial for immunity. This knowledge could be used for the development of new drugs and vaccines.

PI_NAMEs: GERN, BENJAMIN HENRY (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Ablation;Address;advanced analytics;Affect;Antibiotic Therapy;Antibiotics;Antigens;Autopsy;Award;BCG Live;Biological Assay;BLR1 gene;career;career development;Career Mobility;CC chemokine receptor 7;CCR6 gene;CD4 Positive T Lymphocytes;cell type;Cells;Cellular Immunity;Cessation of life;chemokine receptor;Clinical;conditional knockout;CXCR3 gene;Development;Development Plans;Diffuse;Disease Outcome;Dose;effector T cell;Exhibits;experimental study;Flow Cytometry;Future;Genetic;Genetic Transcription;global health;Goals;Granuloma;Homing;Human;Image;Imaging Device;Immune;Immune response;Immunity;Immunization;Immunology;Immunosuppression;improved;In Situ;in vivo;Individual;Infection;Infiltration;innovation;Investigation;Knock-out;Knockout Mice;Knowledge;Laboratories;Learning;Lung;Lung infections;lung pathogen;Lymphocyte;Macrophage;Macrophage Activation;Manuscripts;Microbe;Microscopy;Modeling;Molecular;mouse model;Mus;Mycobacterium tuberculosis;novel;novel therapeutics;novel vaccines;Outcome;Pathogenesis;Pathway interactions;Patients;Physicians;Physiological;Play;pulmonary granuloma;receptor;receptor expression;Research;Resources;response;Role;Scientist;Shapes;Signal Transduction;single cell analysis;Site;Structure of parenchyma of lung;T cell regulation;T-Cell Activation;T-Lymphocyte;Techniques;tertiary lymphoid organ;Testing;Tissues;trafficking;Training;transcriptomics;Transforming Growth Factor beta;treatment strategy;Tuberculosis;tuberculosis granuloma;tuberculosis immunity;tuberculosis treatment;Vaccination;Vaccine Design

PROJECT_TITLE: Dissecting the molecular regulation of T cell localization and function within the Mycobacterium tuberculosis granuloma

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE Candida auris has emerged as a global health threat, causing invasive disease with high mortality. Therapeutic options are limited for this multi-drug resistant pathogen. The proposed studies will uncover immune evasion mechanism(s) for C. auris and provide avenues for the development of therapeutics targeting the fungal and host components involved in this impairment.

PI_NAMEs: NETT, JENIEL E (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: anti-fungal agents;base;Candida;Candida auris;Candidiasis;Carbohydrates;Cell surface;Cell Surface Receptors;Cell Wall;Collection;Data;Death Rate;design;Development;Disease;Disease Outbreaks;Drug resistance;drug resistant pathogen;emerging pathogen;Exhibits;extracellular;Fungal Components;fungus;Future;Genetic;global health;Goals;Hospitals;Human;Hybrids;Hydrolysis;imaging study;Immune Evasion;Immune response;Immune System Diseases;Immunotherapy;Impairment;in vivo;Individual;innovation;Label;Laboratories;Leukocytes;Mannans;mannoproteins;Membrane Glycoproteins;Modeling;Modification;Molecular;mortality;multi-drug resistant pathogen;mutant;Mycoses;Natural Immunity;Neutropenia;neutrophil;new therapeutic target;novel strategies;novel therapeutic intervention;overexpression;Pathogenesis;pathogenic fungus;Pathogenicity;Pattern;Pattern recognition receptor;Phagocytosis;pharmacologic;Public Health;Rattus;receptor;receptor expression;recruit;Refractory;Reporting;response;Risk;Role;Testing;theories;Therapeutic;therapeutic development;therapeutic target;uptake;Virulence;Virulent;Yeasts;Zebrafish

PROJECT_TITLE: Mechanism(s) of pathogenicity for Candida auris

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)M]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: AMHERST

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE The immune response can be beneficial when directed at invading pathogens but it can be harmful when directed at self tissues as in autoimmunity. Regulatory T cells are essential for this balance. The goal of this grant is to understand how regulatory T cells can be manipulated in the context of chronic infection.

PI_NAMEs: WOHLFERT, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acute;Address;Affect;Amphiregulin;Autoimmunity;Brain;Cell Physiology;Central Nervous System;Chronic;chronic infection;Chronically Ill;Cyst;cytokine;Data;Epidermal Growth Factor Receptor;Equilibrium;FOXP3 gene;Genetic;Goals;Grant;Immune;Immune response;immunopathology;immunoregulation;Impairment;Infection;Inflammation;Injury;Interferon Type II;Invaded;Macrophage;Mediating;Morbidity - disease rate;mortality;Mus;Muscle;muscle form;muscle regeneration;muscle repair;Muscle satellite cell;Muscular Atrophy;Parasites;pathogen;Pathogenicity;Pathology;Patients;Play;prevent;Process;Production;Publishing;Quality of life;receptor;Recombinants;Regulatory T-Lymphocyte;repaired;response;Role;self-renewal;Skeletal Muscle;stem cells;Supplementation;T cell response;T-Cell Development;Testing;Therapeutic Intervention;tissue regeneration;tissue repair;Tissues;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;transcription factor

PROJECT_TITLE: T Regulatory cell responses in Toxoplasma-infected muscle

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: CHAMPAIGN

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Fathers often play key roles in the upbringing of children, and affect their offspring’s affective, behavioral and cognitive development, yet we know little about the biological basis of fathering. The project capitalizes on natural variation in paternal care within a single species of stickleback fish to identify genes, brain regions, cell types and neuronal mechanisms that regulate paternal care. Given the evolutionary conservation of molecular mechanisms and brain circuitry regulating parental care, the proposed research could help reveal fundamental principles that are applicable to parental care in humans.

PI_NAMEs: BELL, ALISON MARIE (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TITLE: MIRA: The biological basis of paternal care in stickleback fish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: Vocational instability in Veterans with serious mental illness (SMI) is pervasive, costly, and harmful. Over 75% of Veterans with SMI are unemployed, resulting in economic difficulties and trouble meeting basic needs. Overall, among adults with depression, work dysfunction results in a 36 to 51 billion dollar loss annually. Unemployed Veterans with SMI also suffer major health consequences, including a more severe course of illness and poor recovery over time, leading to increased inpatient and emergency service use. The WORKWELL study will synergistically address these deficits in health, recovery, and work functioning by testing the Cognitive Behavioral Therapy for Work Success (CBTw) intervention. Using a pragmatic design, this project will address work as a major social determinant of health and close the health disparity gap among people with SMI. Further, through promotion of work and healthy thinking, CBTw holds promise to reduce risk of suicide among vulnerable veterans with SMI.

PI_NAMEs: KUKLA, MARINA  (contact)

PROJECT_TERMS: Achievement;active control;Address;Adoption;Adult;Aftercare;Area;arm;Behavioral;Cognitive;cognitive enhancement;cognitive testing;Cognitive Therapy;comparison control;Consultations;Coping Skills;cost;Data;design;Deterioration;disability;Disability prevention;disparity gap;Economics;effectiveness evaluation;Elements;Emergency medical service;Evaluation;experience;Feedback;Feeling suicidal;follow-up;Functional disorder;Future;Goals;Health;health determinants;health disparity;health equity;health related quality of life;health service use;Healthcare Systems;Hospitalization;Hospitals;Hour;Hybrids;implementation evaluation;implementation facilitators;implementation fidelity;implementation framework;implementation strategy;improved;inpatient service;Intervention;Interview;Link;Maintenance;Medical center;meetings;Mental Depression;Mental Health;Mental Health Services;Methods;Modeling;Motivation;novel strategies;Occupations;Outcome;Outcome Study;Participant;Personal Satisfaction;Persons;physical conditioning;Pilot Projects;pilot trial;pragmatic trial;prevent;primary endpoint;primary outcome;Probability;Professional counselor;programs;protective factors;psychoeducation;Quality of life;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recovery;Reporting;Risk Factors;Risk Reduction;Self Efficacy;Series;service utilization;Services;severe mental illness;Site;Site Visit;social health determinants;success;suicidal;suicidal risk;Suicide;Suicide prevention;Supported Employment;Symptoms;Testing;Therapeutic;Therapeutic Intervention;Thinking;Time;Training;Unemployment;uptake;Veterans;Vocation;Vocational rehabilitation;Wages;Work

PROJECT_TITLE: Work as a determinant of health: A pragmatic trial of enhanced cognitive behavioral therapy to bolster competitive work and wellness in veterans with serious mental illness (WORKWELL)

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative    Together,  our  experiments  will  define  individual  and  collective  behaviors  of  osteoblasts  during  bone  regeneration,  and  they  will  reveal  new  molecular  mechanisms  responsible  for  key  behaviors.    Our  experiments  will  uncover  general  principles  of  regeneration  and  will  reveal  processes  that  are  potentially  important for stimulating bone regeneration in clinical settings.

PI_NAMEs: DI TALIA, STEFANO  (contact);POSS, KENNETH D

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Adult;Age;American;Automobile Driving;Behavior;Biography;Biosensor;bone;Bone Diseases;bone imaging;Bone Matrix;Bone Regeneration;cell behavior;Cell division;Cell Proliferation;Cells;Cessation of life;Chemicals;Clinical;Competence;Complex;Computer Analysis;craniofacial development;Cytoskeleton;Data Set;Daughter;Dermal;economic impact;Embryo;Epithelial Cells;Event;experimental study;Extracellular Signal Regulated Kinases;FGF12 gene;Fracture;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic approach;Genetic Transcription;Goals;Growth;Growth Factor;Heterogeneity;Hypertrophy;Image;imaging modality;imaging platform;improved;in vivo imaging;Individual;Injury;insight;Jaw;Label;Laboratories;Life;Ligands;limb amputation;Limb structure;Link;live cell imaging;Maps;mathematical model;Mediating;member;Messenger RNA;Methodology;Methods;migration;Mitogens;Modeling;Molecular;Molecular Genetics;Monitor;Morphogenesis;Natural regeneration;novel;Osteoblasts;Osteoclasts;Pathway interactions;Pattern;pharmacologic;Population;Primordium;Process;programs;Proliferating;Protein Analysis;Publishing;regeneration potential;Regenerative capacity;regenerative growth;Regulation;response;Risk;Signal Transduction;single cell sequencing;Skeletal bone;Skin;socioeconomics;spatiotemporal;Structure;System;Testing;Tissues;transcription factor;transcriptome;transcriptomic profiling;Transgenic Organisms;transmission process;Trauma;Travel;Work;Zebrafish

PROJECT_TITLE: LIVE IMAGING OF BONE REGENERATION IN ZEBRAFISH

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Diabetes;Nutrition

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: Diabetes and pre-diabetes are disorders of glucose regulation that are increasing throughout the world and in the United States. This project addresses the role of specific proteins inside cells that regulate glucose metabolism.

PI_NAMEs: LEE, RICHARD T (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Address;Amino Acid Sequence;Amino Acid Substitution;Amino Acids;Arrestins;beta-arrestin;Binding;Biochemical;Biochemistry;blood glucose regulation;C-terminal;Carrier Proteins;Cells;Collaborations;Cysteine;Data;Diabetes Mellitus;Disease;experimental study;Family;Family member;Fructose;G Protein-Coupled Receptor Signaling;Glucose;Glucose Clamp;glucose metabolism;Glucose Transporter;glucose uptake;glucose-regulated proteins;High Fat Diet;human male;Hyperinsulinism;improved;In Vitro;in vivo;Insulin;Insulin Receptor;insulin sensitivity;insulin signaling;Investigation;Laboratories;Link;Manuscripts;member;Metabolic;metabolic abnormality assessment;metabolic phenotype;Metabolism;Molecular;molecular imaging;mouse model;Mus;Mutation;Obesity;Oxidation-Reduction;Paper;Pathway interactions;Prediabetes syndrome;Proteins;Reporting;Role;SLC2A1 gene;Structure;Tail;Testing;Tissues;TXN gene;TXNIP gene;United States;Visual

PROJECT_TITLE: Molecular Mechanisms of Arrestin-Domain Containing Proteins in Metabolism

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine

ORG_CITY: PITTSBURGH

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PI_NAMEs: CHEN, LUJIA  (contact)

PROGRAM_OFFICER_NAME: WANG, YANLI

PROJECT_TERMS: Antineoplastic Agents;Big Data;Biological;cancer cell;Cell Culture Techniques;Cell Line;Clinical;Data;deep learning;deep learning model;design;Development;Drug Targeting;Future;Genes;Genome;Goals;Growth;improved;Individual;innovation;Learning;Machine Learning;machine learning method;Malignant Neoplasms;Maps;Methods;model design;Modeling;molecular drug target;multi-task learning;Mutation;mutational status;Nature;Ontology;Pathway interactions;personalized genomics;personalized medicine;Pharmaceutical Preparations;Pharmacogenomics;Pharmacotherapy;precision medicine;precision oncology;Proteins;Sampling;Side;Signal Pathway;Signal Transduction;System;Training;tumor

PROJECT_TITLE: Developing deep learning models for precision oncology

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Project Narrative The proposed research is relevant to public health because it will yield a better understanding of risk in autism and thus will lead to improved methods for prevention and treatment. By our exploration of de novo and transmitted variation, it is also relevant to the NIH mission and to the IACC recommendations around identifying genetic risk in ASD.

PI_NAMEs: DALY, MARK JOSEPH (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Acceleration;Adult;Affect;analytical method;ANK2 gene;autism spectrum disorder;autism symptoms;Brain Diseases;cell type;Clinical;cohort;Copy Number Polymorphism;Data;Development;developmental disease;Diagnosis;Disease;disorder risk;exome;Family;First Pregnancy Trimester;Foundations;functional genomics;gain of function;gene discovery;General Population;Genes;Genetic;genetic architecture;Genetic Risk;Genetic Variation;genomic data;Goals;Heterogeneity;improved;Individual;Inherited;innovation;insertion/deletion mutation;insight;International;Knowledge;Learning;Link;loss of function;Mental disorders;Methods;Mission;Mutation;Neurodevelopmental Disorder;neuropsychiatric disorder;novel;novel therapeutics;Nucleotides;Outcome;Pathogenesis;Pathway interactions;Pattern;Play;Population;population based;Prevention;Process;Public Health;rare variant;Recommendation;repetitive behavior;Research;Research Project Grants;Resources;RFX3;Risk;risk variant;Role;Sampling;Sequence Analysis;sex;Signal Transduction;Site;social deficits;Source;Statistical Methods;Symptoms;therapeutic target;Trans-Omics for Precision Medicine;transmission process;United States National Institutes of Health;Variant;whole genome

PROJECT_TITLE: 2/4 The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(60)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: PROJECT NARRATIVE Alzheimer's disease (AD) is a neurodegenerative disease representing the most common cause of dementia – affecting over 5 million Americans – and has no approved disease modifying treatments, which results in an enormous unmet medical need and burden on the healthcare system and society. Uptake and spreading of pathogenic Tau is recognized as a key driver of AD pathology, and is primarily mediated by tau's interaction with the cellular receptor LRP1. The goal of this application is: (1) to identify prototype drugs (chemical probes) that modulate the binding of Tau to LRP1; (2) to explore the activity of these probes in cellular systems to provide insight into the biology of this important receptor; and (3) to advance our long-term goal of developing a disease modifying treatment for Alzheimer's disease.

PI_NAMEs: JACKSON, MICHAEL ;KOSIK, KENNETH STEPHEN (contact)

PROGRAM_OFFICER_NAME: REFOLO, LORENZO

PROJECT_TERMS: Affect;Affinity;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;American;analog;Animal Model;Antibodies;Antisense Oligonucleotides;Automation;Binding;Biochemical;Biological Assay;Biology;Biophysics;Brain;Brain region;Cells;Cellular biology;Chemicals;cheminformatics;Critical Pathways;Dementia;Disease;Disease Progression;DNA;Dose;Dryness;effective therapy;Event;Fluorescence Resonance Energy Transfer;Future;Goals;Healthcare Systems;high throughput screening;human induced pluripotent stem cells;Impaired cognition;In Vitro;in vivo evaluation;in vivo Model;Induced pluripotent stem cell derived neurons;inhibitor;insight;Intervention;knock-down;LDL-Receptor Related Protein 1;Lead;Learning;Libraries;Ligand Binding Domain;Lipoprotein Receptor;manufacturing scale-up;Measures;Mediating;Mediator;Medical;member;Memory;Morphologic artifacts;Mus;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurofibrillary Tangles;Neurons;neurotoxicity;new therapeutic target;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Penetration;Performance;Pharmaceutical Preparations;Phenotype;Powder dose form;prevent;Probability;Procedures;Property;protein aggregation;Proteins;prototype;Publishing;Reagent;receptor;Recombinant Proteins;response;scaffold;screening;Series;Site;small molecule;small molecule libraries;Societies;Surface;System;tau aggregation;tau interaction;tau mutation;tau Proteins;Tauopathies;Testing;treatment strategy;uptake;Validation;Work

PROJECT_TITLE: Preventing Tau uptake by novel inhibitors of tau binding to LRP1

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS-R]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: RICHMOND

ORG_DEPT: DENTISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative A group of bacteria called spirochetes cause syphilis, Lyme disease, leptospirosis, and several other human illnesses. The motility of these spiral- or flat waved- shaped bacteria enables them to invade, disseminate, and damage host organs and tissues. The goal of this project is to understand the basic biology of spirochete motility and its role in the pathogenesis of the diseases. The obtained results may lead to new means of disease prevention and treatment.

PI_NAMEs: LI, CHUNHAO CHRIS (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Achievement;Address;Agar;Animal Model;Anterior;Arthropods;Bacillus subtilis;Bacteria;Bacteria sigma factor KatF protein;Basement membrane;Biochemistry;Biology;Borrelia burgdorferi;Cell Shape;Cells;Cellular Morphology;Chemotaxis;Complex;Cryo-electron tomography;Crystallography;Data;Dermis;Disease;disorder prevention;empowerment;Environment;enzootic;Flagella;Funding;Gel;Genetic;genetic approach;Genome;Geometry;Goals;Hematogenous;Homologous Gene;Human;Immune Evasion;in vivo;Infection;insight;interdisciplinary approach;Interdisciplinary Study;intravital imaging;Invaded;Journals;Knowledge;Laboratories;Leptospirosis;Lyme Disease;lyme pathogenesis;Molecular;Molecular Analysis;Motility;Motor;Movement;Mus;mutant;Order Spirochaetales;Organ;OspC protein;Paper;Pathogenesis;Pathogenicity;Peer Review;periplasm;Play;Process;protein-histidine kinase;Proteins;Publishing;Role;Rotation;Running;Shapes;Site;Solid;structural biology;Structure;success;Surface;Swimming;Syphilis;Systemic infection;tick transmission;Ticks;tissue tropism;Tissues;transcriptome sequencing;transmission process;vector;Virulence;Virulence Factors;Viscosity

PROJECT_TITLE: Understanding Unique Aspects of Motility and Chemotaxis in Borrelia burgdorferi

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: DE

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Prevention;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: Narrative: Most oral cancers originate as oral potentially malignant disorders (OPMDs). OPMDs affect millions worldwide and are challenging for clinicians to identify and manage, contributing to late stage diagnosis and poor outcomes for oral cancer. The Active Biopsy Guidance imaging system developed here will provide guidance to precisely determine when and where to biopsy tissue at risk for oral neoplasia, allowing early treatment and helping to prevent progression to oral cancer in OPMD patients.

PI_NAMEs: GILLENWATER, ANN M;RICHARDS-KORTUM, REBECCA R. (contact);SCHWARZ, RICHARD ALAN

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: Address;Affect;Algorithms;angiogenesis;Area;Back;Benign;Biopsy;Blood Vessels;Cancer Patient;Cells;Collagen;cost;Death Rate;density;Development;Diagnosis;digital;Disease;Dysplasia;Early Diagnosis;Early treatment;Ensure;Epithelium;Excision;Fluorescence;fluorescence imaging;Future;Genomic Instability;global health;Goals;High grade dysplasia;high resolution imaging;high risk;Image;image guided;imaging capabilities;imaging modality;imaging probe;imaging system;Imaging technology;improved;Incidence;Invaded;Lesion;Leukoplakia;Light;Malignant - descriptor;malignant mouth neoplasm;Malignant Neoplasms;Maps;Microscope;Mild Dysplasia;Modality;Molecular;Morbidity - disease rate;Morphology;mortality;Mouth Neoplasms;mouth squamous cell carcinoma;Movement;Mucous Membrane;Multimodal Imaging;multimodality;Mutation;Neoplasm Metastasis;Neoplasms;neoplastic;next generation;novel;Nuclear;optical imaging;Optics;Oral;oral carcinogenesis;oral cavity epithelium;Oral Diagnosis;oral dysplasia;oral lesion;Oral mucous membrane structure;oral tissue;Outcome;Pathologic;Patient-Focused Outcomes;Patients;Positioning Attribute;prevent;Process;Prognosis;Property;Research;Resolution;Risk;Screening for Oral Cancer;Severities;Signal Transduction;Site;Specificity;Stage at Diagnosis;Surface;survival prediction;Survival Rate;System;Technology;Time;Tissues;Work

PROJECT_TITLE: Precision Optical Guidance for Oral Biopsy Based on Next-Generation Hallmarks of Cancer

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease;Lymphatic Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Inflammatory bowel diseases (ulcerative colitis and Crohn’s disease) are chronic inflammatory conditions affecting gastrointestinal track epithelium, with significant morbidity, inadequate treatments, and no cure. Understanding environmental features that control intestinal epithelial stem cells activity is critical for understanding how the intestinal epithelium becomes dysregulated in inflammatory bowel disease. These studies may elucidate novel and specific therapeutic targets for treatment of inflammatory bowel disease, relevant to the NIH’s mission of reducing illness and disease.

PI_NAMEs: NIEC, RACHEL E (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: 3-Dimensional;Address;Affect;antagonist;Award;base;Biology;Blood Vessels;Cardiac Myocytes;career development;cell behavior;Cell Communication;Cell Maintenance;Cell Physiology;cell type;Cells;Cellular biology;Chronic;Coculture Techniques;Communication;Complex;Crohn's disease;Cues;Data;Dedications;defined contribution;Development;Disease;Doctor of Philosophy;Educational workshop;EGF gene;Epithelial Cells;epithelial stem cell;Epithelium;Extracellular Matrix;Fellowship;Fibrosis;gain of function;Gastroenterology;Gastrointestinal tract structure;Gene Expression;Genetic;genetic approach;Grant;gut inflammation;Hair;Hair follicle structure;Health;Homeostasis;Image;Immune;Immunofluorescence Immunologic;Immunology;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inhibitor;Injury;innovation;Institute of Medicine (U.S.);Internal Medicine;intestinal epithelium;Intestines;Knowledge;Laboratories;Large Intestine;Life;Ligands;loss of function;Lymphatic;Lymphatic Capillaries;lymphatic drainage;Lymphatic Endothelial Cells;lymphatic malformations;lymphatic vasculature;Maintenance;Malignant Neoplasms;Maps;medical schools;Mentors;Mentorship;Mesenchymal;Methods;microbial;Microscopy;migration;Mission;Molecular Genetics;Morbidity - disease rate;mouse model;Natural regeneration;Neurons;notch protein;novel;novel therapeutic intervention;nutrient absorption;Organoids;Paneth Cells;Pathogenesis;Predisposition;premature;prevent;Prevention;Process;Program Development;programs;receptor;regenerative;Regulation;research and development;Research Personnel;Residencies;Resolution;Role;self-renewal;Signal Transduction;single-cell RNA sequencing;skills;Skin;Small Intestines;source localization;spatial integration;stem cell biology;stem cell function;stem cell niche;stem cell organoids;stem cells;Structure;Surface;symposium;System;Technical Expertise;Testing;therapeutic target;Three-Dimensional Imaging;Tissues;Training;transcriptomics;Ulcerative Colitis;United States National Institutes of Health;Universities;WNT3 gene;Writing

PROJECT_TITLE: Control of Intestinal Epithelial Function through Lymphatic-Intestinal Stem Cell Communication

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Antibiotic treatment failure is becoming a huge public health concern, as current antibiotic treatment strategies frequently result in incomplete elimination of bacterial populations from host tissues. Surviving bacterial cells are known to have reduced antibiotic susceptibility, however, the pathways that promote bacterial survival within host tissues remain unclear and unexplored. This proposal will address this critical knowledge gap by identifying the pathways that promote bacterial survival and determining if directly targeting these pathways with combination therapeutics could significantly improve treatment efficacy.

PI_NAMEs: DAVIS, KIM  (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Aftercare;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteria;Bacterial Genes;Bacterial Infections;Binding;biological adaptation to stress;Biological Assay;Cell Separation;Cell Survival;Cells;Clinical;cost;Critical Pathways;Development;Doxycycline;drug discovery;Drug Metabolic Detoxication;Drug Targeting;effective therapy;Ensure;Environment;extracellular;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Engineering;Genetic Transcription;Growth;Heterogeneity;Host Defense;Human;human disease;Immune response;improved;In Vitro;in vivo;Infection;interest;Investigation;Knowledge;Mass Spectrum Analysis;Mediating;member;Modeling;monocyte;Motility;mouse model;Mus;Mutation;neutrophil;Neutrophil Infiltration;Nitric Oxide;novel;Nutrient;Pasteurella pseudotuberculosis;pathogenic bacteria;Pathway interactions;Patients;Phagocytes;Pharmaceutical Preparations;Population;Positioning Attribute;Predisposition;Proteome;Proteomics;Public Health;Reactive Oxygen Species;Recurrence;Relapse;Reporter;Residual state;RNA;Role;screening;Spleen;Stress;stressor;Survivors;System;Systemic infection;Testing;Therapeutic;Tissues;tool;transcriptome sequencing;Transgenic Mice;treatment duration;Treatment Efficacy;Treatment Failure;treatment strategy;Validation;Yersinia;Yersinia infections

PROJECT_TITLE: Identifying the pathways associated with bacterial antibiotic persistence within host tissues


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Urethral stricture (narrowing of urethra leading to voiding dysfunction) is a major medical illness, as it affects many older men, and its progression increases with repeated interventions. The major focus of this proposal is to evaluate the pathophysiological changes and molecular mechanisms of injury and urethral wall scarring mechanisms. We will also test if pathogenic microorganisms present in urine play a role in urethral wall damage using in-vitro approaches. We believe the proposed studies have important therapeutic implications for the prevention and treatment strategies for stricture in older patients.

PI_NAMEs: RAJASEKARAN, MAHADEVAN RAJ (contact)

PROJECT_TERMS: Adhesions;Affect;Aging;Antibiotic Resistance;Antibiotics;Bacteria;Bacterial Antibiotic Resistance;Bladder;Butyrates;Cell Culture Techniques;cell injury;Cells;Cicatrix;Clinical;clinical translation;clinically relevant;Coculture Techniques;Consensus;Corpus Spongiosum;Culture-independent methods;Cystoscopy;cytotoxicity;Data;Development;diagnostic development;diagnostic tool;Disease;disease phenotype;Disease Progression;Epithelium;Etiology;Evaluation;experimental study;Extravasation;Failure;fibrogenesis;Fibrosis;Functional disorder;healing;Human;Iatrogenesis;imaging modality;Impaired Renal Function;improved;In Vitro;Infection;Inflammation;Inflammatory Response;Injury;innovation;insight;Intervention;Invaded;Knowledge;Lower urinary tract;Magnetic Resonance Imaging;male;Measurement;Mediating;Medical;Metagenomics;Methods;microbial;microbiome;microbiome signature;microbiota;microorganism;military veteran;Modality;Modeling;Molecular;Monitor;Mucous Membrane;Myofibroblast;non-invasive imaging;novel;novel diagnostics;novel strategies;novel therapeutics;older men;older patient;Operative Surgical Procedures;Outcome;Pathogenicity;Pathologic;Pathway interactions;Patient Recruitments;Patients;Permeability;preservation;prevent;Prevention strategy;Procedures;prophylactic;Recovery of Function;Recurrence;recurrence prevention;Recurrent disease;repaired;Reporting;Ribosomal RNA;Role;Sampling;Seminal;Severities;Severity of illness;Shotguns;Specimen;Stretching;surgery outcome;Surgical complication;Surgical incisions;Taxonomy;Testing;Therapeutic;Therapeutic procedure;therapy development;Tight Junctions;Time;Tissues;tool;Trauma;treatment strategy;Up-Regulation;Urethra;Urethral Stricture;urinary;Urinary Microbiome;Urinary tract;Urine;Urologic Diseases;Urothelial Cell;Urothelium;Veterans

PROJECT_TITLE: Repeated Transurethral Interventions and Progressive Urethral Stricture Disease: Elucidation of Mechanisms and Novel Interventional Strategies


ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Veterans involved in the criminal justice system have complex mental health and medical treatment needs, unstable housing, and an elevated risk for suicide and other mortality. The Veterans Justice Programs serve more than 80,000 Veterans per year but lack systematic methods to prioritize and tailor resources to improve outcomes among justice-involved Veterans. The proposed project aims to identify Veteran, Veterans Justice Programs, Veterans Health Administration, and criminal justice factors associated with successful Veteran outcomes and develop a program evaluation dashboard using perspectives from Veterans and other key stakeholders to contextualize findings. The goal of this research is to produce knowledge and a dashboard the Veterans Justice Programs can use to improve the effectiveness and efficiency of health services delivered to justice-involved Veterans and ultimately improve the health and mortality risk of this population.

PI_NAMEs: FINLAY, ANDREA K (contact)

PROJECT_TERMS: Address;Behavioral Model;Caring;Case Management;Characteristics;Communities;Complex;Congresses;court;Criminal Justice;Crisis Intervention;dashboard;Data;Disease;Effectiveness;Goals;Health;health equity;Health Services;Health Services Administration;Healthcare;Homelessness;Housing;housing instability;Imprisonment;improved;improved outcome;innovation;Intervention;Interview;Jail;Justice;Knowledge;Link;Measures;Medical;Mental disorders;Mental Health;Methodology;Methods;Modeling;Monitor;mortality;mortality risk;operation;Outcome;outreach;parole;Personal Satisfaction;pilot test;Police;Policies;Population;Predictive Factor;Prisons;probation;Process;Program Evaluation;programs;recruit;Research;research and development;Research Personnel;residence;Residential Treatment;Resource Allocation;Resources;Risk;Sampling;service gap;service programs;Services;Specialist;stakeholder perspectives;Statutes and Laws;Structure;suicidal risk;System;tool;United States Health Resources Administration;Veterans;Veterans Health Administration;Visit;Vulnerable Populations

PROJECT_TITLE: Evaluating Health Services for Justice-Involved Veterans to Improve Policy and Practice


ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Obesity and physical inactivity have reached epidemic proportions, resulting in increased rates of chronic diseases, increased risk of death, and substantial health care costs. Veterans with serious mental illness are even more likely to be obese, which contributes to the high rate of co-morbid medical disease and early mortality found in this population. Adapted weight programs have been developed for this population but barriers to utilization exist at the organizational and patient levels. It is likely that these barriers can be addressed by a mobile weight management program, CoachToFit, which focuses on diet and exercise education, and is adapted for Veterans with serious mental illness. CoachToFit was developed in VA, with Veterans with serious mental illness, and is supported by VA peer specialists with lived experience with serious mental illness. CoachToFit was shown to be efficacious for weight loss in a small sample. VA has an opportunity to address obesity in the population with serious mental illness, currently a substantial gap in care.

PI_NAMEs: CHINMAN, MATTHEW  (contact)

PROJECT_TERMS: Address;Area;Awareness;Body Weight decreased;Calories;Cardiovascular system;care delivery;Caring;Cellular Phone;Chronic Disease;Clinic;Clinic Visits;Clinical;clinically significant;Cognitive;Cognitive deficits;comorbidity;cost;Coupled;dashboard;data dashboard;data visualization;design;diaries;diet and exercise;Disease;Disease Management;disorder prevention;Education;education access;efficacy outcomes;efficacy testing;eHealth;Enrollment;Epidemic;Evaluation;evidence base;Evidence based intervention;Focus Groups;future implementation;General Population;Goals;Growth;Health;Health Care Costs;Health Promotion;Healthcare;Healthcare Systems;Homogeneously Staining Region;Improve Access;Individual;Informatics;innovation;International;Intervention;intervention delivery;Interview;Lead;Leadership;Life Expectancy;Lived experience;Maintenance;Measures;Medical;Medical center;member;Mental Health;Methodology;mHealth;mobile computing;Modeling;Morbidity - disease rate;mortality;mortality risk;Motivation;Obesity;online delivery;Outcome;Outcome Assessment;Overweight;Ownership;Patient Preferences;Patients;peer;peer support;Persons;physical inactivity;Policies;Population;Population Intervention;Positioning Attribute;post intervention;Process;programs;Provider;psychosocial;Public Health Informatics;Publishing;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Recommendation;Reporting;Research;Research Design;Sampling;Self Efficacy;service delivery;Services;severe mental illness;skills training;Sleeplessness;smartphone application;Specialist;Technology;Telephone;Testing;Time;tool;traditional care;Transportation;treatment as usual;treatment group;treatment guidelines;trend;United States Department of Veterans Affairs;usability;user centered design;Veterans;Weight;weight loss intervention;Weight maintenance regimen;Wellness coaching

PROJECT_TITLE: CoachToFit: Adapted Weight Loss Intervention for Individuals with Serious Mental Illness


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: PROJECT NARRATIVE Cognitive abnormalities are a major burden in patients suffering from psychiatric disorders, and most available treatments are ineffective in ameliorating cognitive dysfunction. This proposal will use advanced neuroscience technology to investigate one neural circuit component underlying cognitive flexibility, and how this circuit becomes dysfunctional under conditions of chronic stress. This work will provide new neurobiological targets for improved treatments or interventions for stress-induced psychiatric disorders that are characterized by impairments in cognitive flexibility.

PI_NAMEs: ANACKER, CHRISTOPH  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Affect;Behavior;Behavioral;behavioral response;Brain region;Chronic stress;Cognitive;cognitive function;Cognitive Therapy;coping;Data;designer receptors exclusively activated by designer drugs;Disease;Elements;Environment;environmental change;executive function;experimental study;flexibility;generalized anxiety;Genetic;Hippocampus;Image;Impaired cognition;Impairment;improved;Impulsivity;in vivo;Individual;Individual Differences;ineffective therapies;insight;Intervention;Knowledge;Label;Lateral;learned behavior;Learning;Major Depressive Disorder;Measures;Medial;Mediator;Mental disorders;Microscope;Mus;neural;neural circuit;Neurobiology;neuroimaging;Neurons;Neurosciences;new therapeutic target;novel;novel strategies;Obsessive-Compulsive Disorder;optogenetics;Outcome;Outcome Assessment;Output;Pathogenesis;Patients;Pattern;Pharmaceutical Preparations;Post-Traumatic Stress Disorders;Predisposition;Process;Productivity;promote resilience;Psyche structure;Publishing;receptor;Research;resilience;Reversal Learning;Risk Factors;Role;rumination;social defeat;Stress;stress resilience;Stressful Event;stressor;Techniques;Technology;Testing;Therapeutic;Thinking;Time;Update;Virus;Work

PROJECT_TITLE: INVESTIGATING THE ROLE OF HIPPOCAMPUS - ORBITOFRONTAL CIRCUITS FOR COGNITIVE FLEXIBILITY

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: This proposal aims to advance a new platform for high-sensitivity, point-of-care lateral flow assays to allow users to test themselves for HIV infection and rebound. Accurate, frequent HIV self-testing can facilitate early detection of HIV infection and rebound, allowing early treatment and decreasing transmission.

PI_NAMEs: WILLSON, RICHARD  (contact)

PROGRAM_OFFICER_NAME: ESPY, NICOLE JOY

PROJECT_TERMS: Acids;acute infection;Address;Adolescent;Affinity;African American;analog;Android;Antibodies;antigen detection;Antigen-Antibody Complex;antiretroviral therapy;Archives;Avidity;Binding;biobank;Blood;Bulla;Cellular Phone;Chemicals;Chemistry;Clinic;Clinical;cohort;Collaborations;Communicable Diseases;cost;demographics;Detection;detection limit;Development;Diagnostic;Diagnostic Procedure;Dissociation;Early Diagnosis;Early treatment;Ensure;Enzyme-Linked Immunosorbent Assay;Epitopes;Fibronectins;Fluorescence Polarization;fluorophore;Formulation;Goals;Health;Health system;high risk;Hispanic;HIV;HIV diagnosis;HIV Infections;HIV Seropositivity;Home;Human;Human immunodeficiency virus test;Immunoassay;improved;Infection;innovation;insight;Instruction;Interruption;Kinetics;Lateral;lateral flow assay;Libraries;Ligands;Light;Link;Liquid substance;manufacture;Materials Testing;Measurement;Medical;member;Modeling;Monitor;novel;Optics;particle;Patients;pediatric human immunodeficiency virus;Performance;Persons;Phage Display;Phase;point of care;Population;Population Heterogeneity;Populations at Risk;pre-exposure prophylaxis;prevent;protein biomarkers;quality assurance;Readability;Reading;Reagent;recruit;Reporter;Research;Resources;Risk;Sampling;scaffold;seal;self testing;seroconversion;Source;Spanish;Specimen;Technology;test strip;Testing;Time;Translating;transmission process;usability;Viral Load result;Visit;Work

PROJECT_TITLE: Smartphone-based POC Testing for HIV Using Glowstick Chemistry


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative In most real-world conditions, decision makers do not know the probabilities associated with potential outcomes – a state of uncertainty that is defined as ambiguity. Decision makers exhibit ambiguity aversion, preferring to avoid ambiguity even at a cost to themselves, and patients with prefrontal dysfunctions perform especially poorly during choices under ambiguity. This research project seeks to understand the neurophysiological basis for choices under ambiguity; these results will shed light on neural mechanisms for real-world economic choices and provide mechanistic insights into the severe decision-making deficits associated with mental health disorders.

PI_NAMEs: STAUFFER, WILLIAM RICHARD (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Affect;Attitude;Behavior;Behavioral;Belief;blind;Choice Behavior;Code;Cognitive;cognitive system;Coin;Conscious;cost;Data;Decision Making;Decision Theory;Diagnosis;Dopamine;dopaminergic neuron;Economics;Exhibits;expectation;experimental study;Failure;Foundations;Functional disorder;hippocampal pyramidal neuron;human disease;Impairment;Individual;insight;Mathematics;Mediating;Mental disorders;Mental Health;Modeling;Monkeys;Nervous System Disorder;neural;neural circuit;neural correlate;neuromechanism;Neurons;neurophysiology;nonhuman primate;novel;Outcome;overexpression;Patients;Performance;Potassium Channel;Predictive Value;Prefrontal Cortex;Prevalence;Probability;Reporting;Research Project Grants;response;Rewards;Risk;Role;Shapes;Signal Transduction;Subconscious;Symptoms;System;Testing;theories;tool;Uncertainty;Utility Theories

PROJECT_TITLE: Cognitive and reward signals for choices under ambiguity

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD);Nutrition;Obesity

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative One of the challenges in the study of body weight regulation is understanding factors that influence the balance between food intake and energy burned by metabolic processes. This project develops easy-to-use but sophisticated analysis software to analyze the large datasets used in modern energy balance experiments using indirect calorimetry.

PI_NAMEs: BANKS, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Address;Affect;Animals;Awareness;Basal metabolic rate;Body Weight;Body Weight Changes;Body Weight decreased;Burn injury;Cancer Cachexia;Carbon Dioxide;Communities;comparative;Complex Analysis;Computer software;computerized data processing;computing resources;Consensus;Consumption;Data;Data Aggregation;Data Analyses;data cleaning;Data Files;data handling;data management;data reduction;data repository;Data Set;data sharing;density;Deposition;design;Development;Dimensions;Disease;Eating;energy balance;Energy Intake;Energy Metabolism;Equation;Equilibrium;experimental analysis;experimental study;Fatty acid glycerol esters;Feedback;flexibility;Floods;Food Energy;food surveillance;Future;Gases;Goals;graphical user interface;Health;Home;Homeostasis;Human body;improved;Indirect Calorimetry;Infrastructure;instrument;Laboratories;large datasets;Linear Regressions;Literature;Longevity;Manuals;Measurement;Measures;Metabolic;metabolic rate;Metabolism;Metadata;Methodology;Methods;model organism;Modeling;Modernization;Mouse Strains;Noise;Obesity;outreach;Pathogenicity;Pattern;Physiological;Pilot Projects;Policies;Process;Quality Control;Recommendation;Regulation;repository;Reproducibility;Research;Research Personnel;Resources;Sample Size;Scientist;Series;Site;Speed;Standardization;Statistical Data Interpretation;Statistical Methods;Surveys;System;Techniques;Testing;Texas;Thinness;Time;Time Series Analysis;tool;trend;United States National Institutes of Health;usability;user-friendly;Visualization;Visualization software;web-based tool;Weight;Weight Gain

PROJECT_TITLE: CalR: A toolkit and repository for experiments of energy homeostasis using indirect calorimetry

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Cardiovascular;Hematology;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

PHR: PROJECT NARRATIVE The goal of this research project is to produce mechanistic insights into the kindlin-3 signaling in platelets, and provide opportunities for developing more specific and safer therapeutic strategies to prevent and treat thrombosis, a major cause of morbidity and mortality worldwide.

PI_NAMEs: MA, YAN-QING  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Affinity;Alanine;antibody conjugate;Avidity;Binding;Binding Proteins;Biochemical;Biological Assay;Biology;Blood Platelets;Bone Marrow Cells;Cardiovascular Diseases;Cell Adhesion;Cell Separation;Cells;CRISPR/Cas technology;Crystallization;Cytoplasmic Tail;Data;dimer;Dimerization;Electron Microscopy;Family;Fibrinogen;Functional disorder;gene editing technology;Genes;Goals;Gold Colloid;Hematopoietic;Hemorrhage;Hemostatic function;Hereditary Disease;Human;human induced pluripotent stem cells;induced pluripotent stem cell;insight;Integrin beta Chains;Integrins;Interferometry;ITGB3 gene;lentivirally transduced;Lentivirus Vector;Leukocyte Adhesion Deficiency;Leukocytes;Life;Ligands;loss of function mutation;Mediating;Megakaryocytes;member;Molecular;Morbidity - disease rate;mortality;Mus;Mutagenesis;Mutate;Mutation;Myosin Alkali Light Chains;Myosin ATPase;Myosin Light Chains;N-terminal;Neck;novel;Patients;PH Domain;Platelet aggregation;polypeptide;prevent;Process;protein complex;Proteins;Reaction;Receptor Signaling;Regulation;Research Project Grants;Risk;Role;Scanning;Signal Transduction;Site;Specificity;Spectrometry;structural biology;success;Technology;Therapeutic;Thrombosis;thrombotic;Time;Transplantation

PROJECT_TITLE: Kindlin-3 signaling in platelets

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: FAIRFAX

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: GEORGE MASON UNIVERSITY

PHR: PROJECT NARRATIVE  HIV remains an epidemic disproportionately affecting Black sexual minority men (BSMM); Prince George’s County, MD, a primarily Black county, bears approximately three times the national prevalence (823 compared to 289 per 100,000) and incidence (36.0 compared to 11.8 cases per 100,000) of diagnosed HIV cases. My overarching career goal is to contribute to reducing HIV incidence among BSMM through improving the access to and utilization of HIV prevention methods (e.g. PrEP) with a focus on racism, homophobia, HIV stigma, and peer support as determinants of HIV prevention uptake. The project will develop a peer-support intervention focused on increasing PrEP acceptability and initiation among BSMM in Prince George’s County, MD, informed by qualitative interviews and an ethnographic study of MPowerment models among BSMM; this is an important component of larger efforts to reduce HIV disparities in both Maryland and the overall United States.

PI_NAMEs: TURPIN, RODMAN EMORY (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Affect;AIDS prevention;Area;Behavior;Bisexual;black men who have sex with men;Black Populations;Black race;career;career development;Church;Collaborations;Collection;Communication;Communities;community intervention;County;Data;Data Analyses;design;Development;Drops;Economics;Education;Epidemic;ethnographic method;Ethnography;Evaluation;Event;Evidence based intervention;experience;falls;Funding;Future;Gays;Geography;Goals;HIV;HIV diagnosis;HIV disparities;HIV Infections;HIV risk;HIV/AIDS;HIV/STD;Homophobia;Improve Access;improved;Incidence;Income;innovation;Interdisciplinary Study;internalized stigma;Intervention;Intervention Studies;Interview;K-Series Research Career Programs;Knowledge;Lead;Literature;Maryland;Mentors;Methods;metropolitan;Modeling;Outcome;Participant;Pathway Analysis;peer;peer support;pilot test;Population;pre-exposure prophylaxis;Pre-Post Tests;Prevalence;Prevention;programs;racism;recruit;Research;research and development;Research Ethics;Research Personnel;Research Project Grants;resilience;Resources;Respondent;Risk;Risk Behaviors;rural setting;Sampling;Science;sexual minority men;sexual risk reduction;Site;skill acquisition;skills;social;social determinants;social factors;social stigma;Social support;structural determinants;suburb;Testing;therapy design;Training;United States;uptake;Washington

PROJECT_TITLE: A community-based intervention to increase PrEP initiation among Black sexual minority men in Prince George's County, Maryland: Reducing internalized stigma and increasing social support


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Lung;Pulmonary Hypertension;Rare Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: NARRATIVE Patients with pulmonary arterial hypertension (PAH) have a high mortality rate, and in most cases, chronic pressure overload leads to maladaptive remodeling of their right ventricle (RV), which ultimately leads to RV failure. Right heart catheterization (RHC) is currently the gold standard test for PAH diagnosis and follow-up. Yet many centers across the world do not routinely perform RHC during follow-up, for a variety of potential reasons, including its invasive nature, cost, or availability. This application aims to test the feasibility of RV energy state— acquired noninvasively from 3D echocardiography—for assessing RV function and monitoring disease progression/regression in PAH patients.

PI_NAMEs: KHERADVAR, ARASH  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: 3-Dimensional;Address;advanced disease;Assessment tool;Blood;Blood flow;Cardiac Catheterization Procedures;cardiac magnetic resonance imaging;Chronic;Clinical;clinical diagnosis;cohort;cost;Data;Death Rate;Deterioration;Diagnosis;Dimensions;Disease Progression;Disease regression;Echocardiography;ethnic diversity;experience;feasibility testing;follow-up;healthcare burden;Heart;Heart Diseases;hemodynamics;Human;Hypertension;Image;imaging modality;Kinetics;Measurement;Measures;Medical center;Methods;Monitor;Morbidity - disease rate;Nature;non-invasive imaging;particle;Patients;Periodicals;pressure;Process;prospective;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary Heart Disease;Reference Standards;Reproducibility;Right Ventricular Dysfunction;right ventricular failure;Right ventricular structure;standard of care;Structure;Study Subject;Subjects Selections;success;Techniques;Testing;Time;two-dimensional;Velocimetries;Ventricular;Viscosity;Work

PROJECT_TITLE: The state of energy in the right ventricle of patients with pulmonary arterial hypertension

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Our work will determine what role early spontaneous activity and synaptogenic factors play in wiring up retinal circuits. In particular, we are studying the circuits that enable the retina to detect the direction of motion of an object in a visual scene, a canonical system for understanding neural computation. A detailed understanding of the organizing principles that govern the normal development of neural circuits will lead to understanding the origin of some neurological birth defects.

PI_NAMEs: FELLER, MARLA  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Adult;Amacrine Cells;Anatomy;Animals;Anterior;Automobile Driving;Binding;Biological Assay;Biological Models;Calcium;Candidate Disease Gene;Cells;Congenital Abnormality;Coupling;Cues;Data;Development;Dorsal;Electrophysiology (science);experimental study;Eye;ganglion cell;Gap Junctions;Goals;Grant;Head;Image;Inhibitory Synapse;Knockout Mice;Location;Maps;Mediating;Methods;Modeling;Molecular;Motion;mouse model;Movement;Mus;neural;neural circuit;neurodevelopment;Neurologic;neurotransmission;object motion;oculomotor;optic flow;Optics;Pattern;Peripheral;Physiological;Play;Population;Positioning Attribute;receptive field;Reflex action;response;Retina;Retinal Ganglion Cells;Role;Spatial Distribution;starburst amacrine cell;Synapses;synaptic inhibition;synaptogenesis;System;Testing;transcriptome sequencing;Transgenic Mice;two-photon;Variant;vestibular system;Visual;visual deprivation;Visual Fields;visual map;visual stimulus;Visual System;voltage clamp;Work

PROJECT_TITLE: Development of direction selectivity in retina

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative This project seeks to understand and establish predictive rules for how splicing of pre-mRNAs impacts the expression of human genes. These rules will enable improved prediction of gene expression from genomic sequence and likely the identification of new classes of non-coding regulatory variants in the human genome that impact gene expression and contribute to disease phenotypes in a manner dependent on splicing. This work will also guide the application of existing technologies for perturbing splicing to enable the modulation of gene expression for therapeutic applications, such as boosting the expression of a tumor suppressor.

PI_NAMEs: BURGE, CHRISTOPHER B (contact)

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TERMS: 5' Splice Site;5' Untranslated Regions;Abbreviations;Affect;Animals;Antisense Oligonucleotides;Bar Codes;Biological Assay;Cells;Complex;Conserved Sequence;Data;Dependence;design;Detection;Development;disease phenotype;DNA;Elements;Enhancers;Exons;Fluorescence;fungus;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;genomic locus;Genomics;Human;Human Genome;improved;insight;Introns;Learning;Libraries;Location;Logic;mammalian genome;Mammals;Measurement;Mediating;Messenger RNA;Methods;mRNA Precursor;novel;novel strategies;Plants;promoter;Property;Protein Isoforms;Proteins;recombinase-mediated cassette exchange;Regulation;Reporter;Reporting;Research;Ribonucleoproteins;RNA;RNA Decay;RNA Processing;RNA Splicing;RNA-Binding Proteins;Structure;System;Technology;Testing;Therapeutic;Thiouridine;Transcript;Transcription Initiation Site;Transcriptional Activation;Translations;Tumor Suppressor Proteins;Untranslated RNA;Variant;Work

PROJECT_TITLE: Regulation and Function of Alternative mRNA Isoform Expression in Mammals

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Digestive Diseases;Microbiome;Nutrition;Obesity;Prevention

ORG_CITY: COLUMBIA

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Relevance/Project Narrative Recent research has shown that microbes in the human gut can influence a person’s health; dietary fiber is beneficial to these microbes, and fermentation of this fiber produces byproducts, called short chain fatty acids (SCFA) that may signal the gut to make hormones that give people a feeling of fullness. The proposed study will test this idea by feeding people high-fiber diets and measuring blood levels of SCFA, hormones and brain activation in response to a food-cue fMRI task. Successful completion of this study will increase our understanding of how high-fiber diets help people feel full and help them keep their weight down which would result in less risk for the future development of heart disease.

PI_NAMEs: ANGUAH, KATHERENE O (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: absorption;Acetates;Acids;Adult;Animals;Appetite Regulation;Bacteroidetes;Bifidobacterium;Biological;Blood;Blood Glucose;blood glucose regulation;blood lipid;Blood Pressure;Brain;Brain region;Butyrates;Carbohydrates;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;career;career development;Chronic;Clinical;Colon;Colonoscopy;Consumption;Cues;Data;Data Analyses;design;Desire for food;Development;Diabetes Mellitus;Diet;dietary;Dietary Carbohydrates;Dietary Component;Dietary Fiber;Dietary Practices;Eating;executive function;experience;Fabaceae;feeding;Feeling;Fermentation;Fiber;Firmicutes;Firmicutes Bacteroidetes ratio;Food;Functional Magnetic Resonance Imaging;Future;gastrointestinal;Gastrointestinal Hormones;GCG gene;glucagon-like peptide 1;Glucose;Goals;gut microbes;gut microbiome;Health;heart disease risk;Heart Diseases;Hormones;Human;Hypertension;improved;Infusion Technique;Instruction;Intake;Intervention;Intervention Studies;Intestinal Hormones;Intestinal Secretions;Intestines;Lead;Link;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Mediator;men;Mentors;Metabolic;Metabolic syndrome;Metabolism;metabolomics;Methods;Microbe;microbial;microbial composition;microbiome;microbiome analysis;Non-Insulin-Dependent Diabetes Mellitus;nutrient absorption;Nuts;obesity risk;Outcome;Paper;Peptide YY;Persons;Pisum sativum;Play;Population;Production;programs;Propionates;Randomized, Controlled Trials;Recommendation;reduced food intake;Research;response;Rewards;Risk;Risk Factors;Rodent;Role;Satiation;screening;Seminal;Signal Transduction;skill acquisition;skills;stable isotope;Stable Isotope Labeling;Standardization;Testing;Training;translational scientist;Triglycerides;Upper digestive tract structure;Vegetables;Visual;Volatile Fatty Acids;waist circumference;Weight;Weight Gain;Woman;Work;Writing

PROJECT_TITLE: Mechanisms linking dietary fiber, the microbiome, and satiety


NIH_SPENDING_CATS: Genetics

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Many diseases including cancers are directly caused by the misexpression of genetic information that can occur by corruption of multiple steps in the pathway that makes messenger RNAs. A major point of vulnerability in this pathway is at essential steps in mRNA maturation by splicing and cleavage/polyadenylation; steps that must be properly coordinated with synthesis of these RNAs. The work in this proposal will help uncover how the intricate coordination between synthesis and maturation of mRNAs works in healthy cells and how it might go wrong in diseased cells.

PI_NAMEs: BENTLEY, DAVID L (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Affect;base;Binding Proteins;C-terminal;Cells;Complex;Coupling;Disease;DNA;DNA-Directed RNA Polymerase;Enzymes;Event;Excision;Exons;Gene Expression;Gene Transfer;Genes;genetic approach;genetic information;Genetic Transcription;Genomic approach;Goals;Growth;Human;Introns;Invaded;Malignant Neoplasms;Messenger RNA;Modeling;mRNA Precursor;Pathway interactions;Polyadenylation;Polymerase;premature;prevent;Process;Production;Recycling;RNA;RNA chemical synthesis;RNA Folding;RNA metabolism;RNA Polymerase II;RNA Processing;RNA Splicing;RNA-Binding Proteins;Speed;Structure;Tail;Transcript;Transcription Elongation;Transcription Process;transcription termination;Travel;Work

PROJECT_TITLE: Coupling of transcription elongation and termination with pre-mRNA processing

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Genetics;Pediatric;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative Type 1 diabetes is caused autoimmune destruction of the pancreatic beta-cells, but currently there is no therapy that can provide long-lasting improvements in beta-cell function. The aim of this project is to understand the mechanistic roles of two type 1 diabetes loci, CTSH and PGM1, in beta-cells. The proposed experiments will inform us whether these gene products could be targeted to enhance endogenous beta-cell function in type 1 diabetes.

PI_NAMEs: YE, JODY  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Affect;American;Antigen Presentation;Apoptosis;Area;Autoimmune;Autoimmune Diabetes;autoimmune pathogenesis;Autoimmune Responses;Automobile Driving;Beta Cell;biological adaptation to stress;career;Cathepsins;Cell Death;Cell Physiology;Cellular Stress;Child;Clinical;college;CRISPR/Cas technology;CTSH gene;Data Analyses;Development;Diabetes Mellitus;DNA Methylation;Double-Stranded RNA;early onset;effective therapy;endoplasmic reticulum stress;Environment;Environmental Risk Factor;Enzymes;Equipment;Etiology;experimental study;Funding;gene product;Genes;Genetic;genetic epidemiology;Genetic Risk;genetic risk factor;Genetic Transcription;genome wide association study;glycogenesis;glycogenolysis;glycosylation;Goals;Grant;Healthcare;Human;human embryonic stem cell;Hybrids;immunogenicity;improved;In Vitro;in vitro Model;Inbred NOD Mice;innovation;Institution;Insulin;Insulin-Dependent Diabetes Mellitus;interest;islet;Knock-out;Knowledge;Learning;LoxP-flanked allele;Lysosomes;Mediating;Medical Education;Medicine;Mentored Research Scientist Development Award;Mentors;Modeling;Molecular;mouse model;Mus;novel;novel therapeutics;overexpression;Pathogenicity;Pathway interactions;Peptide Hydrolases;Play;Population;post-doctoral training;preservation;Prevalence;prevent;protein degradation;Research;response;risk variant;Role;Running;Scientist;stem cell differentiation;stem cells;Stimulus;Structure of beta Cell of islet;supportive environment;System;Talents;Technology;Training;Transgenic Mice;Translational Research;Translations;Viral;Virus Diseases;Work

PROJECT_TITLE: Investigating the functional roles of CTSH and PGM1 in beta-cells during autoimmune diabetes development

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;Genetics;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: NEW HAVEN

ORG_DEPT: PEDIATRICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Hookworm infection is a leading cause of anemia and malnutrition in poor countries, especially in sub-Saharan Africa. Using both field-based and advanced genomic techniques, we will conduct studies aimed at defining host and parasite factors that mediate hookworm infection, response to deworming and reinfection in endemic settings. The studies proposed here will provide novel insights that will aid future development of effective control strategies for human hookworm infection.

PI_NAMEs: CAPPELLO, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Africa;Africa South of the Sahara;African;Aftercare;Age;Albendazole;Ancylostoma (genus);Anemia;Animal Model;Antibodies;Antibody Response;Antigens;Behavioral;benzimidazole;beta Tubulin;Biology;Blood;Chronic;Clinical;Collaborations;Communicable Diseases;Communities;Complex;Country;Coupled;Data;Development;Disease;disease transmission;DNA;Drug Exposure;Drug Monitoring;Drug resistance;Effectiveness;egg;Enrollment;Epidemiology;Evolution;experience;experimental study;Exposure to;feeding;field study;Foundations;Future;Genes;Genetic;genetic architecture;Genetic Models;Genetic Variation;genomic tools;Genomics;Ghana;Goals;Growth;Hamsters;Helminths;HIV;Hookworm Infections;Hookworms;Human;human data;human disease;human population genetics;Immune response;Immunologic Epidemiology;immunopathology;Impaired cognition;Impairment;In Vitro;in vivo;Infection;Infrastructure;innovation;insight;Institution;Intestines;Kinetics;Laboratories;Legal patent;low and middle-income countries;Malaria;Malnutrition;Maternal and Child Health;Mediating;Medical Research;Methods;Mitochondria;Modeling;Monitor;Morbidity - disease rate;Mucous Membrane;Mutation;Necator americanus;neglected tropical diseases;Nematoda;next generation sequencing;novel;novel strategies;nutrition;Nutritional;Organizational Objectives;Parasites;Pathogenesis;Pattern;Persons;Pharmaceutical Preparations;Pilot Projects;Population;Population Genetics;Predisposition;pressure;Prevalence;Primary Infection;Proteins;Proteomics;PTGS1 gene;Public Health;Reagent;Recommendation;Reporting;Reproducibility;Research;Research Personnel;Resistance;resistance frequency;Resources;response;Risk;Risk Factors;secretory protein;Soil;Study Subject;Techniques;Technology;tool;translational study;transmission process;Tuberculosis;Universities;Vaccination;vaccine development;vaccine efficacy;vaccine response;World Health Organization

PROJECT_TITLE: Translational studies of hookworm infection in Ghana

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Environmental factors promote adult-onset disease by altering epigenetic information in the germ line of the affected individuals and their progeny. Experiments proposed in this application will explore mechanisms by which exposure to BPA contributes to the establishment of altered epigenetic states in the male and female germlines. This study will also characterize processes by which altered epigenetic information can be transmitted from the gametes to the embryo after fertilization to affect gene expression in differentiated cells of adult tissues resulting in obesity in subsequent generations.

PI_NAMEs: CORCES, VICTOR G. (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Address;Adult;Affect;Androgen Receptor;Androgens;autism spectrum disorder;Binding Sites;Biological;Biology;bisphenol A;Cell Differentiation process;cell type;Cells;Chemicals;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;demethylation;Deposition;Desire for food;Development;Diet;Disadvantaged;Disease;Distal;DNA;DNA Methylation;Dose;Eating;Embryo;embryo cell;Endocrine Disruptors;Enhancers;Environment;environmental change;Environmental Risk Factor;Epiblast;Epigenetic Process;epigenome;ESR1 gene;Estrogen Receptors;estrogenic;Event;experimental study;Exposure to;Failure;fascinate;Feedback;Female;Fertilization;Food;Frequencies;Gene Expression;Generations;Genes;Germ Cells;Germ Lines;Gonadal Steroid Hormones;Health;histone modification;Histones;Human;Hypothalamic structure;Individual;insight;Knowledge;Laboratory Animals;Leptin resistance;Literature;male;Malignant Breast Neoplasm;Mammals;Meiosis;Methods;Molecular;Mouse Strains;Mus;Nature;Neurons;Nuclear;Obesity;Onset of illness;Organism;overexpression;Phenotype;Plasticizers;Play;Pre-implantation Embryo Development;pregnant;prenatal exposure;Process;promoter;Proteins;Publishing;recruit;Regulatory Element;Reporting;Risk;RNA;Role;Site;Somatic Cell;sperm cell;Stimulus;Stress;Structure of primordial sex cell;System;Time;Tissues;transcription factor;transgenerational epigenetic inheritance;transmission process;Variant;Weight Gain;Work;zygote

PROJECT_TITLE: Mechanisms of transgenerational epigenetic inheritance

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]