NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE There is an urgent need for a well-tolerated intervention to slow autosomal dominant polycystic kidney disease (ADPKD) progression and improve vascular health and symptom burden. Sodium-glucose cotransporters-2 inhibitors (SGLT2i) have a track record of tolerability and safety in patients with proteinuric kidney diseases but have not previously been studied in patients with ADPKD. This pilot and feasibility randomized trial of the SGLT2i empagliflozin in patients with ADPKD at high risk of progression will test the safety and tolerability of this medication, and provide preliminary estimates of its efficacy on disease progression, vascular health, and symptoms, to support a subsequent definitive phase III clinical trial of the clinical efficacy of SGLT2i in ADPKD patients.

PI_NAMEs: CHONCHOL, MICHEL BENJAMIN (contact);SELIGER, STEPHEN L.

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Adherence;Adverse event;Affect;Alternative Therapies;Animal Model;antagonist;Anti-Inflammatory Agents;Antioxidants;Aorta;arterial stiffness;Arteries;Autosomal Dominant Polycystic Kidney;Blood Vessels;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Chronic Kidney Failure;Clinical;Clinical Trials;constriction;cost;Cyst;Cystic kidney;Cystic Kidney Diseases;Data;Development;Diabetes Mellitus;diabetic;Disease;disease model;Disease Progression;disorder risk;Diuresis;Dose;double-blind placebo controlled trial;efficacy clinical trial;Elasticity;End stage renal failure;Epithelial Cell Proliferation;Epithelial cyst;Etiology;Event;Exclusion;experience;Feasibility Studies;Fibrosis;Frequencies;Functional disorder;Genetic Diseases;Genitourinary System Infection;Glomerular Filtration Rate;Glucose;Goals;Growth;Growth and Development function;Health;health related quality of life;Hereditary Disease;high risk;improved;Individual;inhibitor;Injury;insight;interest;Intervention;Intervention Studies;Investigation;Kidney;Kidney Diseases;Life;Liquid substance;loss of function;Macula densa;Magnetic Resonance Imaging;Measurement;Measures;Modeling;Morbidity - disease rate;mortality;Natriuresis;non-diabetic;Osmosis;Outcome;Oxygen;Participant;Patients;Pharmaceutical Preparations;Phase;Phase III Clinical Trials;Physiologic pulse;Placebos;Plasma;pressure;progression risk;Quality of life;Randomized;randomized trial;randomized, clinical trials;rat KIM-1 protein;Rattus;receptor expression;Renal function;Research;Rodent;Safety;safety assessment;safety testing;Sample Size;side effect;Sodium;Specific qualifier value;standard of care;success;symporter;Symptom Burden;Symptoms;Testing;tolvaptan;Tubular formation;urinary;Urinary tract;Vasopressin Receptor;Vasopressins

PROJECT_TITLE: Feasibility study of empagliflozin in patients with autosomal dominant polycystic kidney disease


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Regenerative Medicine;Wound Healing and Care

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed study will investigate fundamental cellular and molecular mechanisms of how the vascular network of the skin - the largest organ in our body - develops, maintains adult homeostasis, and repairs itself to support life-long function and health. I have established a state of the art live imaging approach to visualize, manipulate, and longitudinally track blood vessel cells in the live mouse skin, to interrogate for the first time the cellular dynamics underlying skin vascular remodeling and homeostasis. This research is of paramount importance, given the indispensable function of the vasculature to all tissues in our body and the yet unknown mechanisms that differentiate neonatal versus adult vascular regeneration.

PI_NAMEs: KAM, CHEN YUAN  (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: 4D Imaging;Ablation;Address;Adult;Age;Architecture;Behavior;Birth;Blood flow;Blood Vessels;cell behavior;cell motility;cell type;Cells;Cellular Morphology;Characteristics;Coupling;Cutaneous;Data;Development;Endothelial Cells;Endothelium;Epidermis;experimental study;Genetic;Health;hemodynamics;Homeostasis;Human;Image;imaging approach;Imaging Techniques;Imaging technology;improved;in vivo;infancy;Injectable;Injury;injury and repair;innovation;intravital imaging;Kinetics;Lasers;Maintenance;Mediating;Membrane;migration;Modeling;Molecular;Monitor;Morphology;mouse model;multiphoton microscopy;Mus;mutant;Mutant Strains Mice;Natural regeneration;Neonatal;neonate;network architecture;Nutrient;Organ;Pathologic;Pathology;Physiological;Play;Process;programs;Property;regenerative;Regenerative capacity;Regulation;repaired;Reporter;Research;Resolution;response;revascularization;Role;Signal Transduction;Skin;Skin repair;Solid;spatiotemporal;Structure;Techniques;Technology;Temperature;Testing;Time;time use;tissue oxygenation;Tissues;tool;transcriptomics;vascular abnormality;Vascular Endothelial Growth Factors;Vascular Permeabilities;Vascular regeneration;Vascular remodeling;vessel regression;Visualization;wound;wound healing;wound vascularization

PROJECT_TITLE: Investigating the principles of physiological and pathological vascular remodeling via 4D imaging of live mouse skin

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE Fetal growth restriction (FGR) raises the risk of stillbirth and neonatal death. It is well known that FGR develops when the normal rise in uterine blood flow is curtailed and that growth-restricted fetuses have lower blood O2 levels but it is unlikely that lower blood flow is solely responsible for restricting growth because O2 supply still exceeds fetal O2 consumption. This project will identify how and when lower blood flow and hypoxia affect placental and fetal metabolism so as to slow fetal growth. Such information is essential for refining therapeutic strategies for restoring fetal growth under conditions of hypoxia, a goal that has, to date, proven elusive

PI_NAMEs: JULIAN, COLLEEN GLYDE (contact);MOORE, LORNA G.;WESOLOWSKI, STEPHANIE R

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Adenosine;Affect;Altitude;amino acid metabolism;Antioxidants;Arteries;Biochemical;Biological Assay;Biometry;Blood;Blood flow;Blood Vessels;Bolivia;Cardiometabolic Disease;Cell Respiration;Cesarean section;Chronic;cohort;Consumption;Data;design;Equilibrium;Event;Fatty Acids;fetal;Fetal Growth;Fetal Growth Retardation;Fetal Reduction;Fetal Weight;Fetus;fetus hypoxia;Frequencies;Gases;Gestational Age;gestational hypoxia;Goals;Growth;Homeostasis;Hour;Human;Hypoxia;Impairment;improved;in vivo;Incidence;inhibitor;Knowledge;lifetime risk;Maternal Age;Measurement;Measures;Mediating;Metabolic;metabolic abnormality assessment;Metabolism;metabolomics;Mitochondria;Modeling;Mus;Myography;Myometrial;Neonatal Mortality;Newborn Infant;Nucleotides;Nutrient;nutrient metabolism;Oxidation-Reduction;Oxidative Stress;Pathogenesis;Perfusion;pharmacologic;Placenta;Population;preference;Pregnancy;Process;Production;Reactive Oxygen Species;reduced uteroplacental blood flow;Regulation;Resistance;Respiration;respiratory;response;Risk;Role;Sampling;Sea;sensor;Sheep;sheep model;Side;Signal Transduction;Site;stillbirth;Sum;Testing;Therapeutic;therapy development;Third Pregnancy Trimester;Tissues;Tracer;Umbilical vein;uptake;Uteroplacental Circulation;Uterus;Vascular resistance;Vasoconstrictor Agents;Vasodilation;Vasodilator Agents;Woman;Work

PROJECT_TITLE: Effects of chronic hypoxia and AMPK activation on uteroplacental perfusion, placental metabolism and the regulation of fetal growth

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Mental Health;Neurodegenerative;Neurosciences;Parkinson's Disease;Precision Medicine;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Lewy body dementia (LBD) is a devastating disorder of thinking, memory, and emotional disturbances that currently has no cures or effective therapies. Novel biomarkers of LBD promise to advance our ability to manage and treat this disease. We propose to develop novel high-impact protein biomarker panels for LBD in blood and cerebrospinal fluid (CSF) using an innovative proteomic strategy that incorporates network analysis, brain- biofluid integration, and targeted biomarker validation.

PI_NAMEs: LEVEY, ALLAN I;SEYFRIED, NICHOLAS THOMAS (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Acceleration;Address;Alzheimer's Disease;Amygdaloid structure;Anti-Anxiety Agents;Antipsychotic Agents;aptamer;Automobile Driving;Autopsy;biobank;Biological Assay;Biological Markers;biomarker discovery;biomarker panel;biomarker validation;Blood;Blood Vessels;Brain;brain based;Brain region;candidate identification;candidate marker;Caregivers;Cerebrospinal Fluid;Cholinesterase Inhibitors;Clinical;Cognitive;cohort;Collection;Data;Delusions;Dementia;Dementia with Lewy Bodies;Detection;Deterioration;Diagnostic;Disease;Distress;DNA;Early Diagnosis;effective therapy;Emotional Disturbance;Endothelium;Enrollment;experience;experimental study;Fostering;frontal lobe;Functional disorder;Future;Health Care Costs;Immune;Immunologics;Individual;innovation;Knowledge;Lewy Body Dementia;Lewy Body Disease;Link;Longitudinal cohort;Mass Spectrum Analysis;Measures;Mediating;Medicine;Memory;Metabolism;Methods;Molecular Profiling;Monitor;multidisciplinary;myelination;Nerve Degeneration;Network-based;Neurodegenerative Disorders;Neurons;neuropathology;neuropsychiatry;novel;novel marker;Paranoia;Parkinson Disease;Parkinson's Dementia;Pathway Analysis;Pathway interactions;Patients;personalized care;personalized therapeutic;Pharmacotherapy;Phenotype;phenotypic data;Plasma;programs;Progressive Disease;promoter;protein biomarkers;Proteins;Proteome;Proteomics;recruit;Registries;Research;risk stratification;RNA;Sampling;Schedule;Serum;Source;Specificity;Synapses;synuclein;synucleinopathy;targeted biomarker;Techniques;Temporal Lobe;Therapeutic;therapeutic biomarker;Thinking;Tissues;Translating;treatment response;Validation;validation studies;Visual Hallucination;Whole Blood

PROJECT_TITLE: Novel Protein Biomarkers of Corticolimbic Pathophysiology in Lewy body Dementia


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Structural, process, and outcome measures of home- and community-based services are fragmented by setting, service, and payer, and are not specific to dementia. This Research Network will build the data infrastructure to promote the development, harmonization, and utilization of measures that are necessary to ensure equitable access to, and outcomes of, these services. The Network will also build and diversify the research bench by engaging and supporting underrepresented researchers, coordinating activities with other networks, and training researchers to develop and disseminate policy-relevant research to improve dementia HCBS.

PI_NAMEs: SHIH, REGINA A (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Acceleration;Address;aging population;Alzheimer's Disease;American;Bathing;behavioral health;Caregivers;Caring;cognitive function;Communication;community based service;community living;Complex;Consumer Preferences;Cues;Data;data centers;data infrastructure;Data Sources;data tools;Dementia;dementia care;Development;disability;Disabled Persons;Disparity;diversity and equity;Eating;Educational workshop;Electronic Mail;Ensure;Equity;equity, diversity, and inclusion;ethnic difference;Evaluation;evidence base;experience;Family Caregiver;Fostering;Funding;Goals;Group Meetings;Growth;Health;Health Services Research;Home;improved;inequitable distribution;innovation;Institution;Knowledge;learning network;lens;marginalized population;Measurement;Measures;Medicaid;Medical;meetings;Memory;Mentorship;Methods;Monitor;Movement;Network Infrastructure;Observational Study;older adult;Outcome;Outcome Measure;Performance;Persons;Policies;Population;Preparation;Privatization;Process;Process Measure;Productivity;Provider;Publications;Quality of life;R24;racial difference;recruit;Reporting;Research;Research Activity;Research Personnel;Resources;Scientist;Selection Bias;service uptake;Services;social media;Sterile coverings;Structure;success;Surveys;System;Training;Translational Research;Translations;Underrepresented Populations;United States Centers for Medicare and Medicaid Services;user-friendly;verbal;waiver;web site;Work;working group;Writing

PROJECT_TITLE: Research Network for Alzheimer's Disease Home and Community Based Services


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Pediatric

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Children with nephrotic syndrome are exposed to prolonged courses of steroids and other immunosuppressant medications with serious side effects. Given the adverse side effect profile and variable efficacy of these medications, there is an urgent need to identify novel and safe therapies to treat nephrotic syndrome in children. The proposed research utilizing transauricular vagus nerve stimulation will provide preliminary data that are essential to conduct a large-scale trial that will address a significant knowledge gap and will pave the way for evaluation of an innovative, non-pharmacologic, non-invasive, steroid-sparing approach to the treatment of idiopathic nephrotic syndrome in children.

PI_NAMEs: SETHNA, CHRISTINE B (contact)

PROJECT_TERMS: 17 year old;Action Potentials;Adherence;Affect;Aftercare;Age;Animals;Antibodies;Antibody Formation;Attenuated;Autoantibodies;B-Lymphocytes;cell motility;Child;Chronic;Clinical Trials;Confidence Intervals;confirmatory clinical trial;cytokine;Data;design;Devices;Diabetes Mellitus;Disease;Double-Blind Method;Dyslipidemias;Edema;efficacy outcomes;Enrollment;Etiology;Evaluation;Exposure to;feasibility testing;Future;Goals;Growth;Hypertension;Immune;Immune response;Immune system;Immunologic Markers;immunoregulation;Immunosuppressive Agents;Infection;Inflammatory;innovation;interest;Kidney;Kidney Failure;Knowledge;Measures;Mediating;Methods;Mission;Monitor;monocyte;Multi-Institutional Clinical Trial;National Institute of Diabetes and Digestive and Kidney Diseases;nephrin;Nephrotic Syndrome;nephrotoxicity;novel;Organ;Outcome;Participant;Pathogenesis;Pathway interactions;patient safety;Pharmaceutical Preparations;Pilot Projects;Placebos;podocyte;Process;Proteins;Proteinuria;Protocols documentation;Randomized;randomized placebo controlled trial;recruit;Reflex action;Regulatory T-Lymphocyte;Relapse;Renal glomerular disease;Reperfusion Injury;Research;Resistance;Resources;response;Rheumatoid Arthritis;Role;Safety;Sample Size;Serum;side effect;Signal Transduction;Site;Specific qualifier value;Spleen;Steroid therapy;Steroid-resistant idiopathic nephrotic syndrome;Steroids;Systemic Lupus Erythematosus;Testing;Time;TNF gene;treatment response;trial comparing;vagus nerve stimulation;Vagus nerve structure

PROJECT_TITLE: A Pilot Study of Transcutaneous Auricular Vagus Nerve Stimulation for the Treatment of Idiopathic Nephrotic Syndrome in Children

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Patient Safety;Prevention;Rehabilitation

ORG_CITY: CLEVELAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative The “Randomized Trial of Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients” will test the hypothesis that compared to usual care having a designated mobility technician to provide supervised ambulation up to 3 times daily will improve patients’ mobility at discharge. We will then use prediction modeling to identify which patients benefit most from the intervention. Finally, we will assess the economic impact of the mobility technicians from the health system perspective.

PI_NAMEs: ROTHBERG, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Accelerometer;Acute;acute care;Adopted;Adult;Bed rest;care costs;care episode;Characteristics;Clinical;cost;Cost Measures;COVID-19;COVID-19 pandemic;Data;deconditioning;decubitus ulcer;Dedications;Delirium;Discipline of Nursing;Dose;economic evaluation;economic impact;Effectiveness;Effectiveness of Interventions;Eligibility Determination;experience;falls;functional decline;functional restoration;functional status;Health;Health care facility;health economics;Health system;Home;Hospital complications;Hospital Costs;hospital readmission;Hospitalization;Hospitals;human old age (65+);Iatrogenesis;implementation science;improved;Injury;Inpatients;interest;Intervention;intervention cost;Knowledge;Length of Stay;loss of function;Measures;Medical;Medicine;Modeling;Movement;multidisciplinary;Nosocomial pneumonia;novel;Nurses;Observational Study;Occupations;older adult;older patient;Operative Surgical Procedures;Outcome;Participant;Patient Discharge;patient mobility;Patient-Focused Outcomes;Patients;Physical therapy;Physicians;Pilot Projects;Pneumonia;Predictive Analytics;predictive modeling;prevent;program costs;programs;Randomized;randomized trial;Rehabilitation therapy;Risk;Risk Factors;Safety;Savings;Skin;Syndrome;Techniques;Testing;Time;Training;treatment as usual;venous thromboembolism;Venous Thrombosis;Work;Wrist

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Lung

ORG_CITY: BALTIMORE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative In this study, I will leverage single-cell RNA-sequencing analysis to identify novel, important locally acting soluble factors in a functional human lung microvascular niche to improve pulmonary microvascular maturation in acellular lung scaffolds. This work will lead to the creation of a novel pulmonary microvascular platform which specifically resembles many physiological aspects of the native lung environment. Such a platform could be used for pulmonary vascular disease modeling and drug testing.

PI_NAMEs: YUAN, YIFAN  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Adult;Alveolus;Biological Models;Biomimetics;Bioreactors;Blood Vessels;BMP5 gene;Capillary Leak Syndrome;Cell Maturation;Cells;Characteristics;computerized tools;COVID-19;Cues;cytokine;Data;Data Set;Development;Disease;disease model;Distal;drug candidate;drug mechanism;Drug Screening;drug testing;Endothelial Cells;Endothelium;Engineering;Environment;Enzyme-Linked Immunosorbent Assay;Extracellular Matrix;Functional disorder;Genomics;hemodynamics;Homeostasis;Human;improved;In Vitro;Inflammation;Inflammatory;Inhalation;Injury;Interferon Type II;Lipopolysaccharides;Lung;Lung Diseases;Microfluidics;Modeling;novel;novel coronavirus;Organ;Organoids;paracrine;Paracrine Communication;Phase;Phenotype;Physiological;Physiology;primary pulmonary hypertension;Property;Publishing;pulmonary vascular disorder;scaffold;Sepsis;shear stress;Signal Induction;Signal Transduction;single-cell RNA sequencing;solute;Structure;System;Thrombus;tissue culture;TNF gene;tool;Trees;Vascular Endothelium;vascular factor;Vascular Permeabilities;Vascularization;Work

PROJECT_TITLE: Reconstructing native soluble cues in vascularized whole lung scaffolds

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: GM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Dental, Oral, and Craniofacial Disease;Immunotherapy;Machine Learning and Artificial Intelligence;Prevention;Rare Diseases

ORG_CITY: STOCKTON

ORG_NAME: UNIVERSITY OF THE PACIFIC-STOCKTON

ORG_STATE: CA

PHR: Prognostic biomarkers are critically needed to determine patients with oral dysplastic lesions at risk for malignant transformation. We propose an innovative approach that combines high-dimensional imaging mass cytometry (IMC) and machine learning predictive modeling (iEN) to analyze a total of ~200 Formalin-Fixed Paraffin-Embedded (FFPE) patient tongue biopsies from the Oral Pathology Archive at the University of the Pacific (UOP), Arthur A. Dugoni School of Dentistry. Our goal is to establish a single- cell atlas of premalignant immune microenvironment in oral dysplasia and to identify immune features that predict the malignant transformation to oral cavity squamous cell carcinoma (OCSCC).

PI_NAMEs: HAN, XIAOYUAN  (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Archives;Atlases;bioinformatics pipeline;biomarker identification;Biopsy;cancer invasiveness;Cell Count;Cells;Clinical;Collaborations;Cytometry;Data;Dental;Dental Students;Development;Diagnosis;Dysplasia;Elasticity;Formalin;Goals;high dimensionality;High grade dysplasia;Histologic;Histopathologic Grade;Human;Image;Imaging technology;Immune;immune cell infiltrate;Immunoassay;Immunofluorescence Immunologic;improved;innovation;Lesion;machine learning algorithm;machine learning prediction;Malignant - descriptor;Malignant Neoplasms;Microscopy;Mild Dysplasia;molecular marker;mortality;mouse model;mouth squamous cell carcinoma;multidisciplinary;multiplexed imaging;Myelogenous;Myeloid-derived suppressor cells;Natural Immunity;Nature;neighborhood association;Neighborhoods;novel;novel therapeutics;Oral;oral dysplasia;Oral Pathology;Paraffin Embedding;Patients;Phagocytes;Phenotype;Play;pre-doctoral;predictive modeling;premalignant;Prognosis;Prognostic Marker;Proliferating;Proteins;Recurrence;Research;Risk;Risk Factors;Role;Sampling;School Dentistry;Severities;Signal Transduction;Stains;student participation;Surface;System;Tongue;Translational Research;tumor;Tumor-associated macrophages;tumor-immune system interactions;Universities

PROJECT_TITLE: Single-cell immune landscape in the oral dysplasia's malignant transformation


ADMINISTERING_IC: NR

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Palliative Care;Prevention

ORG_CITY: WOODLAND HILLS

ORG_NAME: PEACEFULLY, INC.

PHR: PROJECT NARRATIVE The proposed research is consistent with broader public health goals focused on improving patient end-of-life care and patients’ expressed preferences for help with more comprehensive end-of-life care planning that includes advance care planning as well as other end of life issues such as emotional, relational, and financial. The proposed study will address this public health issue by refining and pilot testing a web-based program designed to assist cancer patients in comprehensively planning for their end of life, including advance care planning, estate planning, organizing documents and contacts, and addressing emotional, social, and spiritual needs. Therefore, this study is aligned with patients’ expressed preference for a more comprehensive approach to planning for end of life, as well as the NCI’s long-term goals of improving end of life planning and development of digital health tools, the NINR’s goals of identifying multi-dimensional palliative care needs of older adults and their family caregivers, and the NIA’s objective of incorporating social determinants of health and patient-centered variables.

PI_NAMEs: GOOD, JENNIFER  (contact);SHEN, MEGAN JOHNSON

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Address;Advance Care Planning;Advanced Malignant Neoplasm;Agreement;Behavioral;Benchmarking;Burial;cancer care;Cancer Patient;Caregivers;Caring;Cause of Death;Cessation of life;Computer software;Control Groups;Data;design;Development;digital;digital health;Dimensions;Disease;Distress;effective intervention;Emotional;end of life;end of life care;Enrollment;Event;Exercise;Family;Family Caregiver;Feedback;field study;Goals;group intervention;Health;health goals;Health Technology;Home;improved;innovation;Instruction;Intervention;intervention program;intervention refinement;Intervention Trial;iterative design;Lawyers;Left;Life;Link;loved ones;Malignant Neoplasms;Market Research;men;Modification;Motivation;Needs Assessment;neglect;novel strategies;older adult;Online Systems;Outcome Assessment;Palliative Care;Participant;Patient Care;patient engagement;patient oriented;Patients;Personal Satisfaction;Persons;Phase;pilot test;pilot trial;post intervention;preference;Process;programs;Protocols documentation;Public Health;Quality of life;Randomized;Reporting;Research;Resources;satisfaction;Secure;Self Efficacy;Services;social;social health determinants;Spiritual care;Spiritual well-being;Spirituality;Testing;theories;tool;treatment as usual;Treatment Efficacy;usability;user centered design;web-based tool;Woman;Work;Writing

PROJECT_TITLE: A comprehensive web-based program to help advanced cancer patients plan for end of life


NIH_SPENDING_CATS: Clinical Research;Lung;Pulmonary Hypertension;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Circulating platelets are implicated in the development and progression of pulmonary arterial hypertension (PAH), a deadly disease of the lung vasculature for which there is no cure; but how these cells contribute to the disease is unknown. In this study, we will determine how changes in metabolism inside the platelet cause the platelet to spark inflammation in the blood vessels of the lung, which leads to injury of the blood vessel wall and development of PAH. If successful, this project will define the long unknown role of platelets in PAH progression, which will potentially lead to the development of therapies that target the platelet to treat PAH.

PI_NAMEs: SHIVA, SRUTI  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Alpha Granule;Animal Model;antagonist;Anticoagulants;Attenuated;Biochemical;Blood Platelets;Blood Vessels;CASP1 gene;cell injury;Cell Proliferation;Cells;Chimeric Proteins;Clinical Trials;Coculture Techniques;Complex;Data;Development;Disease;efficacy testing;Endothelial Cells;endothelial dysfunction;Endothelium;Event;experimental study;fatty acid oxidation;Fatty Acids;Functional disorder;Genetic;Guanosine Triphosphate Phosphohydrolases;Human;hypertension treatment;Hypoxia;in vivo;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Injury;Interleukin-1 beta;interleukin-1beta-converting enzyme inhibitor;Knockout Mice;Label;Leukocytes;Link;lipidomics;Lung;Lung Diseases;lung imaging;Measures;Mediating;Mediator;Metabolic;Metabolic dysfunction;Metabolic stress;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;mouse model;multiphoton imaging;Mus;NADPH Oxidase 1;Natural Immunity;neutrophil;novel;Oxidants;Oxidation-Reduction;P-Selectin;Pathogenesis;Pathology;Pathway interactions;Patients;Plasma;Platelet Activation;Production;Proliferating;pulmonary arterial hypertension;pulmonary arterial pressure;pulmonary artery endothelial cell;pulmonary vascular remodeling;Pulmonary Vascular Resistance;receptor;right ventricular failure;Rodent Model;Role;Scheme;Signal Transduction;Surface;targeted treatment;Testing;therapeutic target;therapy development;Thrombocytopenia;thromboinflammation;thrombotic;Transgenic Organisms;Up-Regulation;vascular inflammation;Vascular remodeling;Wild Type Mouse

PROJECT_TITLE: Platelet Metabolic Stress Induces Thrombo-Inflammation to Drive Endothelial Dysfunction in PH

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: ANN ARBOR

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed research is relevant to human health because the development of selective chemical reactions will enable the synthesis of new pharmaceutical agents and tools to study biological systems. Specifically, the proposed research will lead to the development of sustainable, environmentally enzyme-mediated reactions. Ultimately, this work will also lead to fundamental discoveries that will be applied to human health.

PI_NAMEs: NARAYAN, ALISON  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Amino Acids;Area;Benchmarking;Biochemical Reaction;bioinformatics tool;Biological;biological systems;catalyst;chemical function;chemical reaction;Chemicals;Communities;Complex;Computer Models;Derivation procedure;design;Development;Environment;Enzymes;functional group;Goals;Grant;Health;Human;Hydroxylation;Mediating;Methods;Modernization;National Institute of General Medical Sciences;Natural Products;Nucleotides;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Substance;Protein Family;Proteins;Reaction;Reagent;Research;Site;small molecule;Sustainable Development;tool;Work

PROJECT_TITLE: Expanding the synthetic utility of enzymes


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

PHR: “Evolve to Next-Gen ACT” (ENACT) will develop and distribute new software tools that allow scientists and clinicians from 57 CTSA institutions to search for and analyze de-identified data from the electronic health records of over 142 million Americans across the country. Our user- friendly ENACT interface can be used on standard laptops to access many types of data from many sources to advance new medical discoveries for everyone and help with clinical care planning for individual patients.

PI_NAMEs: REIS, STEVEN E (contact);VISWESWARAN, SHYAM

PROGRAM_OFFICER_NAME: HARTSHORN, CHRISTOPHER

PROJECT_TERMS: Address;Adopted;Agreement;American;analytical method;Behavior;Businesses;Caring;Characteristics;Clinical;clinical care;clinical data warehouse;clinical decision-making;clinical research site;cloud based;Code;cohort;collaboratory;Complex;complex data;Computer software;cost;Country;dashboard;Data;data access;Data Analyses;Data Collection;data de-identification;data exchange;data harmonization;data modeling;data quality;Data Reporting;Data Set;data sharing;Democracy;design;Ecosystem;EHR research;Electronic Health Record;Ensure;Environment;firewall;Fostering;Funding;genetic variant;Health;Human;improved;improved outcome;in silico;Individual;individual patient;Informatics;informatics tool;innovation;Innovation Corps;Institution;interoperability;laptop;Learning;lifestyle factors;Marketing;Medical;Methodology;Methods;model development;Modeling;Monitor;Multi-Institutional Clinical Trial;National Center for Advancing Translational Sciences;National Clinical Trials Network;Natural Language Processing;Ontology;Outcome;Outcomes Research;Patient Care;patient privacy;Patient-Focused Outcomes;Patients;Phenotype;pilot trial;Plant Leaves;Population;programs;Provider;Public Health Informatics;Recommendation;Recovery;Reporting;Research;Research Personnel;Resources;Scientist;Services;Site;SNOMED Clinical Terms;Software Tools;Source;Specific qualifier value;statistical and machine learning;statistics;Sustainable Development;System;Testing;Time;tool;Translating;Translational Research;translational scientist;Trust;Update;user-friendly

PROJECT_TITLE: ENACT: Translating Health Informatics Tools to Research and Clinical Decision Making


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Services;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Women with gestational diabetes mellitus (GDM), a common pregnancy complication, face elevated risk for later developing type 2 diabetes. Health professionals recommend that women with GDM be screened for diabetes after delivery and participate in lifestyle programs to help prevent type 2 diabetes; however, most women do not receive these services. This study will develop an outreach strategy to help maximize the number of women with GDM who take advantage of health services for type 2 diabetes prevention.

PI_NAMEs: BROWN, SUSAN DENISE (contact);FERRARA, ASSIAMIRA

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Affect;Body Weight;California;Caring;Chronic;Clinical;clinical risk;Cluster randomized trial;Communities;comparative effectiveness;Complication;cost;Cost Sharing;Data;Decision Making;design;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;diabetes risk;Diagnosis;discount;Early treatment;Electronic Health Record;empowerment;Enrollment;ethnic diversity;evidence base;Face;fasting plasma glucose;feasibility testing;Fostering;Fright;Future;Gestational Diabetes;Glycosylated hemoglobin A;Goals;Guidelines;Health;health assessment;Health Professional;Health Services;Health system;Healthcare;high risk;Hour;Infrastructure;innovation;interest;Intervention;Life Style;Link;Mediator;Medical;Methods;Minority;Modeling;Motivation;motivational enhancement therapy;multiphase optimization strategy;neglect;Non-Insulin-Dependent Diabetes Mellitus;novel;OGTT;online delivery;Outcome;outreach;Pathway interactions;Patient Outcomes Assessments;Patients;Perinatal Care;Phase;Population;postpartum care;Postpartum Period;pragmatic trial;Pregnancy;Pregnancy Complications;Prenatal care;prevent;Prevention;Preventive;Preventive care;primary outcome;Problem Solving;programs;Provider;psychologic;racial diversity;Randomized;randomized trial;Recommendation;Reporting;Risk;Sampling;screening;Screening Result;secondary outcome;Secure;Self Care;Self Direction;Self Efficacy;Services;Surveys;Testing;theories;therapy development;Time;uptake;Visit;Weight;Woman;Work

PROJECT_TITLE: Optimizing a scalable intervention to maximize guideline-recommended diabetes testing after GDM

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cannabidiol Research;Cannabinoid Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Natural Products;Pain Research;Palliative Care;Sleep Research;Therapeutic Cannabinoid Research

ORG_CITY: Boulder

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

PHR: Project Narrative Many cancer patients suffer from pain, sleep, and mood problems and are using cannabis to relieve these symptoms. Cannabis may provide such relief but may also produce negative side effects including cognitive impairment, an especially problematic issue for cancer patients, indicating more research on cannabis use in the cancer context is required. In this endeavor, the present study seeks to compare the use of hemp-derived CBD with and without THC versus placebo on measures of sleep, pain, mood, subjective and objective cognitive functioning, and quality of life within 185 cancer patients.

PI_NAMEs: BRYAN, ANGELA  (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: active method;Acute;Address;affective disturbance;Age;American Cancer Society;Anxiety;Attenuated;Blood;cancer diagnosis;Cancer Patient;Cancer Survivor;cancer therapy;Cannabidiol;Cannabinoids;Cannabis;Chemicals;chemobrain;chemotherapy;Cognitive deficits;cognitive function;cognitive task;Data;design;Diagnosis;Disease;Dose;Effectiveness;efficacy evaluation;Encapsulated;experience;experimental study;Hemp;Hour;Impaired cognition;improved;Individual;interest;Legal;Literature;Long-Term Effects;Malignant Neoplasms;marijuana use;Marketing;Measures;Memory;Mental Depression;Mental Health;Moods;multiple drug use;Outcome;Pain;Pain intensity;Pain interference;pain reduction;Palliative Care;Patients;Pharmaceutical Preparations;Pilot Projects;pilot trial;Placebo Control;placebo group;Placebos;Plants;Polypharmacy;prescription opioid;Prevalence;Prevention;Proliferating;psychologic;psychological distress;Quality of life;Radiation;Randomized;randomized placebo controlled trial;reduce symptoms;Reporting;Research;Review Literature;Risk;Role;Scientist;side effect;Sleep;Sleep Disorders;Sleep disturbances;sleep quality;Standardization;Stress;Surveys;Symptoms;synthetic cannabinoid;Task Performances;Testing;Tetrahydrocannabinol;trend;United States;Variant;Work

PROJECT_TITLE: Cannabis for Palliative Care in Cancer: A Placebo-controlled Randomized Trial of Full Spectrum Hemp-derived CBD/THC

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

PHR: Public Health Relevance Statement Antimicrobial resistance is an urgent problem that will result in millions of unnecessary deaths in the near future if the development of new antimicrobials is not significantly increased. We have worked diligently in developing a novel class of peptide-based antibiotics named A4X that successfully overcomes the limitations of current antimicrobial peptides and the urgent antimicrobial resistance problem associated with existing standard-of-care antibiotics. Our proposal outlines a rationalized design with the milestone-driven approaches to carry out a series of mechanistic and preclinical testing studies to further develop A4X. The goal of this proposal is to deliver a safe and effective new antimicrobial drug into IND-enabling ready at the end of the study to help initiate future clinical trial and overcome the crisis of antimicrobial and antibiotic resistance.

PI_NAMEs: DI, YUANPU PETER (contact);LI, JIAN

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acinetobacter baumannii;acute toxicity;Address;Advanced Development;Amino Acids;Aminoglycosides;Animal Model;Animals;Anti-Bacterial Agents;anti-microbial drug;anti-microbial peptide;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteremia;Bacteria;bacterial resistance;beta-Lactamase;beta-Lactams;Biology;Blood Circulation;carbapenem resistance;carbapenem resistant Enterobacterales;Carbapenem-resistant Acinetobacter;Ceftazidime;Cells;Cessation of life;Chemicals;Clinical;clinical application;clinical development;Clinical Trials;Colistin;Combating Antibiotic Resistant Bacteria;commercialization;cytotoxicity;Data;design;Developing Countries;Development;dosage;drug candidate;drug discovery;Drug Kinetics;effective therapy;emerging pathogen;Engineering;Epithelial Cells;Erythrocytes;Escherichia coli;Evaluation;Exhibits;Fibroblasts;fighting;Fluoroquinolones;Future;Generations;Goals;Gram-Negative Bacterial Infections;Grant;Hospitals;Host Defense;Human;improved;Incidence;Infection;inhibitor;Intellectual Property;International;intravenous administration;Klebsiella pneumoniae;Lead;lead candidate;lead optimization;Legal patent;Leukocytes;Life;Lung;Lung infections;Mammalian Cell;Medical;Membrane;microorganism;Modification;Molecular Conformation;mouse model;Multi-Drug Resistance;Multiple Bacterial Drug Resistance;Mus;Names;National Institute of Allergy and Infectious Disease;nephrotoxicity;next generation;Non-Rodent Model;novel;novel antibiotic class;novel therapeutics;Organism;pathogen;Pathogenicity;Peptide Antibiotics;peptide drug;Peptides;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;Polymyxin B;Polymyxin Resistance;Polymyxins;Positioning Attribute;pre-clinical;pre-clinical research;preclinical development;Preclinical Testing;programs;Property;Proteins;Public Health;public health relevance;rational design;Rationalization;Rattus;Reporting;Research;Research Proposals;Resistance;Resistance development;resistant Klebsiella pneumoniae;resistant strain;Respiratory Tract Infections;Rodent Model;Safety;Series;standard of care;Structure-Activity Relationship;Superbug;System;Therapeutic;Therapeutic Agents;Time;Toxic effect;Trademark;Treatment Cost;United States;unnatural amino acids;virtual;Work

PROJECT_TITLE: Developing a novel class of peptide antibiotics targeting carbapenem-resistant Gram-negative organisms


ADMINISTERING_IC: DA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: HOUSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: Cravings precede drug relapses in Substance Use Disorders, and the sequence from craving to relapse is poorly understood, as is the cravings a construct, which spans affective and behavioral components. In this project, we plan to develop novel data science methods to synthesize and characterize craving and affective signatures and build craving and affect detection and prediction models with multi-modal data along neuronal, physiological, affective, behavioral, and contextual dimensions.

PI_NAMEs: MOUKADDAM, NIDAL ;SANO, AKANE  (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: addiction;Affect;Affective;Alcohols;behavior measurement;Behavioral;behavioral response;biobehavior;Brain;Cellular Phone;Characteristics;Clinical;Clinical assessments;Cocaine;Cognitive;Coupled;craving;Cues;Data;Data Science;Databases;design;Detection;Development;digital phenotyping;Dimensions;drug relapse;Emotional;Evidence based intervention;Functional Magnetic Resonance Imaging;Impairment;insight;Intervention;intervention effect;Knowledge;Label;Laboratories;Life;machine learning model;Measurement;Measures;Methamphetamine;Methods;mindfulness;Modality;Modeling;Monitor;multidimensional data;multidisciplinary;multimodal data;multimodality;Neurons;novel;novel strategies;Occupational;Opioid;Patients;Pattern;Persons;pharmacologic;Physiological;Pilot Projects;predictive modeling;prevent;Psyche structure;Public Health;Relapse;Research;response;Running;sensor;social;Source;Stimulus;substance use;Substance Use Disorder;substance use treatment;Testing;wearable device;wearable sensor technology;Withdrawal Symptom

PROJECT_TITLE: SCH: Multidimensional Data Science Approach: Measuring and Characterizing Craving and Affective Profiles in Substance Use Disorders


NIH_SPENDING_CATS: Aging;Clinical Research;Genetics;HIV/AIDS;Infectious Diseases;Physical Activity

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: NARRATIVE/RELEVANCE The lifespan of people with HIV has been considerably extended, but the burden of age-related comorbidities remains high among them. This proposal will evaluate the role of mitochondrial function and DNA methylation in biological aging (represented by frailty phenotypes, epigenetic clock acceleration, and immunosenescence) among people with HIV, as well evaluate the potential of exercise to reverse mitochondrial function damage and epigenetic clock acceleration caused by HIV. Completion of this proposal will enhance the understanding of the role of mitochondrial function in age acceleration among people with HIV as well as highlight potential interventions to mitigate the damage, which ultimately could lead to improvements in treatment and long-term care strategies for people aging with HIV.

PI_NAMEs: SUN, JING  (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Adult;age acceleration;Age related comorbidities;Aging;aging process;aging related;aging related disease;antiretroviral therapy;Area;biobank;Biological Aging;Biological Assay;Blood;career;Cell Aging;Cell Nucleus;Cell Signaling Process;certificate program;Characteristics;Chronic;Clinical Research;cohort;Collaborations;comorbidity;Complex;Data;design;DNA analysis;DNA copy number;DNA Methylation;drivers of aging;Epidemiologist;Epidemiology;epigenetic clock;Epigenetic Process;epigenome-wide association studies;Exercise;exercise intervention;experience;frailty;Funding;Future;Gait speed;General Population;Genes;Genetic;genetic analysis;genetic association;Goals;Hand Strength;Health;high risk;HIV;HIV Infections;Immunologics;immunosenescence;improved;Inflammation;Infrastructure;International;Interval training;Intervention;Intervention Studies;Intervention Trial;Intravenous;K-Series Research Career Programs;Knowledge;Laboratories;Leadership;life span;Link;Long-Term Care;Measurement;Measures;Mentored Research Scientist Development Award;Mentors;Methylation;methylation pattern;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Moderate Exercise;Molecular;mortality;multiple omics;novel;Nuclear;Outcome;Participant;Pathway interactions;Persons;Phenotype;Physical Function;Physicians;polygenic risk score;Population Study;Predisposition;programs;prospective;Public Health Schools;Quality of life;Research;Research Personnel;Respiration;Risk;Role;Scientist;Severity of illness;Site;Specimen;T-Lymphocyte;The Multicenter AIDS Cohort Study;therapy development;Time;Training;Training Programs;United States National Institutes of Health;Visit

PROJECT_TITLE: Collaboration on HIV and AgingResearch through the Study of Mitochondria

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: NARRATIVE Much mental health research relies on measurements of brain activity across different parts of the brain, and often poses difficult problems in statistical analysis. The research supported by this grant develops new methods of analyzing brain signals as they evolve across time. Of special interest is the way networks of interacting brain components may change under varying conditions.

PI_NAMEs: KASS, ROBERT E (contact)

PROGRAM_OFFICER_NAME: KIM, DOUGLAS SUN-IL

PROJECT_TERMS: Acceleration;Applications Grants;Area;Attention;Behavior;behavior measurement;Behavioral;Biophysics;Brain;brain based;Brain region;Collaborations;Collection;Communication;Coupling;Data;deep neural network;design;Development;Dimensions;Disease;effectiveness evaluation;Electrodes;Event;Evolution;Frequencies;Functional disorder;Goals;Grant;Graph;Group Structure;high dimensionality;improved;Individual;Information Networks;insight;interest;Investigation;Lead;Letters;Measurement;Measures;Mental Health;Methods;Modeling;Movement;network dysfunction;neural;neural model;neural network;Neural Network Simulation;neuromechanism;Neurons;neurophysiology;neurotransmission;Noise;novel strategies;novel therapeutics;Patients;Phase;Physiological;Process;programs;Psychopathology;Reaction Time;Research;Research Support;Role;screening;Series;Signal Transduction;simulation;Source;spatiotemporal;Specific qualifier value;Statistical Data Interpretation;Statistical Models;statistics;Stochastic Processes;Structure;Synaptic Transmission;Techniques;Technology;Time;Time Series Analysis;tool;Training;vector;Weight;Work

PROJECT_TITLE: Analysis of Nonstationary Point Process Data

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Wound Healing and Care

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Corneal diseases and injuries that are often manifested through limbal stem cell dysfunction and loss are the major cause of visual impairment and corneal blindness. Our previous studies and scRNA- seq preliminary data formed the premise for the present proposal to uncover the regulatory role and contribution of each miR-146a main targeted pathways such as EGFR, Notch and NF-κB signaling in corneal epithelial regeneration in wounded and unwounded states in normal and diabetic corneas. This research will significantly advance our understanding of miR-146a mechanisms of regulation in corneal epithelial homeostasis, wound healing, and disease-related alterations for future therapeutic approach.

PI_NAMEs: GHIAM, MEHRNOOSH SAGHIZADEH (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acute;Adherens Junction;Basal Cell;Biological Process;Blindness;Cell Differentiation process;Cell Fate Control;cell fate specification;cell growth regulation;Cell Maintenance;Cells;Clinical;Cornea;Corneal Diseases;corneal epithelium;Corneal Injury;Corneal Opacity;corneal regeneration;cytokine;Data;Defect;diabetic;diabetic patient;differential expression;Disease;effective therapy;empowerment;Epidermal Growth Factor Receptor;Epithelial Cells;epithelial stem cell;epithelial wound;Epithelium;epithelium regeneration;Erinaceidae;Exposure to;Functional disorder;functional gain;Funding;Future;Gene set enrichment analysis;Genes;Goals;Health;Healthcare Systems;Heterogeneity;Homeostasis;Human;In Situ Hybridization;Individual;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;Injury;innovation;Interleukin-1;interleukin-1 receptor-associated kinase;Keratopathy;limbal;Maintenance;Mediating;Microarray Analysis;MicroRNAs;Mitotic;Molecular;Natural regeneration;notch protein;Numbness;Organ Culture Techniques;Pathogenesis;Pathologic;Pathway interactions;Patients;Population;Population Heterogeneity;Proteome;Proteomics;Quality of life;Quantitative Reverse Transcriptase PCR;Receptor Signaling;Recurrence;regenerative healing;Regulation;Regulatory Pathway;Research;Resolution;Role;Signal Transduction;single-cell RNA sequencing;Small Interfering RNA;small molecule inhibitor;Source;stem cell biomarkers;stem cell homeostasis;stem cells;Stimulus;Stress;Stromal Cells;Techniques;Technology;Therapeutic;Tissues;TNF receptor-associated factor 1;TNF receptor-associated factor 6;transcriptome;transcriptome sequencing;Transfection;translational study;treatment strategy;Vision;Visual impairment;Visualization;wound healing

PROJECT_TITLE: The Role of MicroRNAs in Normal and Diseased Corneal Epithelial Homeostasis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_CITY: Columbus

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative The Multidisciplinary Research Training in Dental, Oral, and Craniofacial Sciences (MARTDOCS) program is designed to train the next generation of basic and clinical research faculty in dental, oral, and craniofacial research. This comprehensive program is built on the strong foundation of more than 20 years of successful training of PhD, DDS-PhD, and postdoctoral scholars by the OSU College of Dentistry Oral Biology Graduate Program (OBGP) and its partner programs in the OSU College of Medicine, the Biomedical Science Graduate Program (BSGP) and Neuroscience Graduate Program (NSGP). MARTDOCS uses a flexible graduate curriculum and established interdisciplinary research programs to provide high quality training and career development in a highly interactive health sciences center that has support from the College of Dentistry, College of Medicine, OSU Graduate School, OSU Center for Clinical and Translation Science Translation Science (CCTS) and the NIDCR.

PI_NAMEs: MALLERY, SUSAN R (contact);SHERIDAN, JOHN F

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Pediatric

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Humans are exposed to a complex mixture of chemicals through their environment, and it is of critical public health importance to assess how these exposures impact human health and risk of adverse outcomes. However, it is very challenging to disentangle the health effects of the different exposures due to dimensionality, nonlinearities, interactions and high correlation. This project develops transformative new tools for obtaining interpretable inferences on exposure effects for both mixtures and toxicological screening.

PI_NAMEs: DUNSON, DAVID BRIAN (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Adverse effects;adverse outcome;Air;Assessment tool;Biological;Breathing;Chemical Exposure;Chemical Structure;Chemicals;Child;Childhood;Complex Mixtures;Computer software;curse of dimensionality;Data;Data Set;Data Sources;Databases;Detection;Dimensions;early childhood;Eating;Environment;Environmental Health;Environmental Pollutants;epidemiologic data;Epidemiology;epidemiology study;exposed human population;Exposure to;flexibility;Food;Funding;Goals;Health;high throughput screening;Human;improved;In Vitro;in vivo;Individual;Industrial Product;innovation;insight;Journals;Life;Literature;Methods;Modeling;Molecular Structure;National Health and Nutrition Examination Survey;National Institute of Environmental Health Sciences;neurodevelopment;Outcome;Output;Performance;programs;Public Health;Publishing;Reproducibility;Research;Research Project Grants;response;Risk;screening;simulation;software development;Statistical Models;Testing;Time;tool;Toxic effect;Toxicology;user-friendly;Variant;Water;Weight

PROJECT_TITLE: Improving inferences on health effects of chemical exposures

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative:  This project develops a novel, continually adaptive learning framework which automatically and continually integrates and curates biomedical literature and knowledge. It allows researchers and curators to continually integrate individual lab-generated articles with large-scale public repositories, thereby enabling biomedical users to perform custom and context-based integrative literature analysis and exploration. This project produces a novel web-based tool for biomedical researchers and curators to access and navigate the useful scientific information at a personal level.

PI_NAMEs: CLARK, TIMOTHY W;SHEFFIELD, NATHAN ;ZHANG, AIDONG  (contact)

PROGRAM_OFFICER_NAME: WANG, YANLI

PROJECT_TERMS: Acceleration;adaptive learning;Adoption;Artificial Intelligence;base;Biomedical Research;Clinical;Communities;Complex;Custom;Data;deep learning;design;Development;digital;Dimensions;Environment;Evaluation;Expert Systems;flexibility;Foundations;Goals;improved;Individual;interest;journal article;Knowledge;knowledge base;knowledge curation;knowledge network;Laboratories;Learning;Literature;Machine Learning;Measures;Methods;Mission;Modeling;Morphologic artifacts;natural language;Navigation System;next generation;novel;outreach;Printing;Process;public repository;Records;Reporting;Research;Research Personnel;Resources;search engine;Semantics;Services;Strategic Planning;Structure;System;Techniques;Time;tool;Training;United States National Library of Medicine;Update;web-based tool

PROJECT_TITLE: Continually Adaptive Machine Learning Platform for Personalized Biomedical Literature Curation and Exploration


NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences

ORG_CITY: AMHERST

ORG_DEPT: BIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Understanding of the central regulation of growth and energy homeostasis is important to fight against dwarfism and various metabolic diseases. Despite great advances in physiological understanding of the hypothalamic neurons that control these processes, how they are formed during development is ill-defined, and this critical issue will be dissected in this proposal.

PI_NAMEs: LEE, JAE W (contact);LEE, SOO-KYUNG

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Area;Binding;Biochemical;biomarker panel;cell type;Cells;ChIP-seq;chromatin immunoprecipitation;conditional knockout;course development;Data;Data Set;Development;Developmental Gene;Dwarfism;Embryo;Embryonic Development;energy balance;Ensure;Exclusion;experimental study;feeding;fighting;FOXP2 gene;gene regulatory network;Genes;Genetic Markers;Genome Mappings;genome-wide;genome-wide analysis;Goals;Grant;Growth;Growth and Development function;Homeostasis;Hypothalamic structure;Immunohistochemistry;Impairment;improved;In Situ Hybridization;in vivo;Individual;innovation;insight;Knockout Mice;Life;Link;Metabolic Diseases;Methods;Molecular;mouse genetics;mouse genome;Mus;Mutant Strains Mice;neuron development;Neurons;novel;Pathway interactions;Pattern;Physiological;Play;postnatal;Process;Production;progenitor;programs;Regulation;Regulatory Pathway;Reporting;Reproduction;Research;Role;single-cell RNA sequencing;Somatotropin-Releasing Hormone;Structure of nucleus infundibularis hypothalami;Testing;Time;transcription factor;transcriptome;Work

PROJECT_TITLE: Transcription Factors Governing the Development of GHRH-neurons


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Immunotherapy;Neurosciences;Nutrition;Radiation Oncology;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative  This proposal will investigate the role of the metabolic enzyme isocitrate dehydrogenase-1 (wt-lDH1) in high grade glioma (HGG), and by evaluating the novel wt-lDH1-specific inhibitor, 13i, developed by AbbVie, will develop a novel therapeutic strategy to target wt-lDH1 activity for the treatment of HGG.

PI_NAMEs: STEGH, ALEXANDER H. (contact);WAHL, DANIEL R

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Ablation;Adjuvant;alpha ketoglutarate;Anabolism;anti-cancer research;Apoptosis;Binding;Biochemical;Biological Models;Brain;cancer cell;Carbon;Cell Death;Cell Death Induction;Cell division;cell growth;Cell membrane;Cell model;Cells;checkpoint inhibition;Clinical;Credentialing;Data;Decarboxylation;design;Development;Enzymes;Event;fatty acid biosynthesis;Fatty Acids;Genetic;Genetic Recombination;Genotype;Glial Fibrillary Acidic Protein;Glioma;Glutathione;glutathione peroxidase;Goals;Growth;Homeostasis;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immunocompetent;Immunotherapy;In Vitro;in vivo Model;inhibitor;Iron;Isocitrate Dehydrogenase;Isocitrates;Isotopes;knock-down;Knockout Mice;Laboratories;Link;lipid biosynthesis;Lipid Peroxidation;Lipid Peroxides;lipidome;lipidomics;Lipids;Lipoxygenase;Liquid Chromatography;loss of function;LoxP-flanked allele;Luciferases;Malignant Glioma;Mediating;Mediator;Membrane;membrane biogenesis;Membrane Lipids;Metabolic;Modality;Modeling;Molecular;Monounsaturated Fatty Acids;Mus;Mutation;NADP;neoplastic cell;Neurosphere;Normal tissue morphology;novel;novel therapeutic intervention;Nutrient;overexpression;oxidation;Oxidation-Reduction;Oxidoreductase;Patients;Peroxidases;pharmacologic;Phospholipids;Polyunsaturated Fatty Acids;prevent;Production;PTEN gene;radiation response;Radiation therapy;Radio;Reactive Oxygen Species;Reduced Glutathione;Reducing Agents;Regulation;repaired;Reporting;Resistance;RNA Interference;Role;Signal Transduction;Testing;Therapeutic;tool;Toxic effect;TP53 gene;Tracer;tumor;tumor growth;Tumor Promotion;Tumor Suppressor Proteins;uptake;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Inhibition of wild-type IDH1 as a ferroptosis-inducing therapeutic approach for the treatment of malignant glioma.

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: EAST LANSING

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Project Narrative Differences in disease risks among individuals in human populations can be characterized as quantitative traits with a complex genetic basis. However, our understanding of how DNA variation causes phenotypic variation remains incomplete. The proposed studies will reveal how DNA variation can lead to variation in the efficiency of mRNA translation, improving our knowledge about the genetic basis of complex quantitative traits, including human diseases.

PI_NAMEs: HUANG, WEN  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Affect;Alleles;Biological Assay;Biological Models;Biological Process;Black race;Chromosome Mapping;Code;Complex;Data;density;Development;developmental plasticity;Dimensions;disorder risk;Dissection;DNA;DNA Sequence;Drosophila genus;Drosophila melanogaster;Elements;Embryo;Embryonic Development;Environmental Risk Factor;Equilibrium;Genes;Genetic;genetic evolution;Genetic Transcription;Genetic Variation;genome wide association study;genome-wide;Genotype;Heritability;Human;human disease;Hybrids;improved;Inbred Strain;Inbreeding;Individual;innovation;Knowledge;Learning;Link;Maps;Masks;Measurement;Measures;Messenger RNA;model organism;Molecular;molecular phenotype;mRNA Translation;novel;Parents;Phenotype;Population;Population Genetics;Process;protein degradation;Proteins;Quantitative Trait Loci;Reporter;Resolution;ribosome profiling;Ribosomes;RNA;RNA Decay;Role;Shapes;Source;study population;Testing;Text;trait;Transcript;Translations;Untranslated Regions;Variant

PROJECT_TITLE: Genetic variation and evolution of translational control in Drosophila

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Complementary and Integrative Health;Dementia;Microbiome;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE: While nearly 6 million Americans are currently living with the debilitating effects of Alzheimer’s disease, the lack of treatment options and impoverished understanding of the underlying causes of cognitive decline, metabolic impairment, impaired gut function and other symptoms leads to severe impairments in quality of life. The proposed research will utilize an aged rat model of Alzheimer’s disease (TgF344-AD rats) to determine whether alterations in gut microbiome composition influence cognitive outcomes and the degree to which this is mediated by alterations in metabolic functioning. Findings from the proposed experiments may reveal specific peripheral targets that can be leveraged for the generation of potential therapeutic strategies against Alzheimer’s disease and related symptoms.

PI_NAMEs: HERNANDEZ, ABIGAIL LYNN (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Age;Age-associated memory impairment;aged;Aging;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;American;Amyloid beta-Protein;Animal Model;Area;Bacteria;Blood;blood glucose regulation;Brain;brain dysfunction;brain health;brain metabolism;Brain-Derived Neurotrophic Factor;Butyrates;career development;Cause of Death;Central Nervous System;Cognition;Cognitive;cognitive function;cognitive process;Data;Dementia;density;Diabetes Mellitus;dysbiosis;Energy Metabolism;Experimental Designs;experimental study;Foundations;Functional disorder;functional outcomes;Future;gastrointestinal;gastrointestinal system;Generations;Geroscience;Goals;gut dysbiosis;gut health;gut microbiome;gut microbiota;gut-brain axis;Health;Hippocampus;Homeostasis;Human;human data;Impaired cognition;Impairment;improved;innovation;Insulin Resistance;insulin sensitivity;Intervention;Investigation;Ketone Bodies;Knowledge;Leadership;Letters;Link;Measures;Mediating;Mentorship;Metabolic;Metabolic Diseases;Metabolism;Metagenomics;microbiome alteration;microbiome analysis;microbiome composition;microbiota;Modeling;multidisciplinary;Nature;Neurobehavioral Manifestations;Neurodegenerative Disorders;neurogenesis;neuropathology;normal aging;novel;novel therapeutics;Obesity;older adult;Outcome;Pathologic;Pathology;Peripheral;Phenotype;Physiological;Population;Poverty;Prefrontal Cortex;prevent;primary outcome;probiotic supplementation;Probiotics;Production;programs;Quality of life;Rattus;Research;Resources;Risk;Rodent;Rodent Model;Scientific Advances and Accomplishments;Streptomycin;Supplementation;Symptoms;System;targeted treatment;tau Proteins;Techniques;Testing;Therapeutic;Therapeutic Intervention;Thinness;Training;Transgenic Organisms;Volatile Fatty Acids;Work;β-amyloid burden

PROJECT_TITLE: Influence of gut on metabolism and cognition in Alzheimer's disease.


ORG_CITY: CHICAGO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative The IRACDA program is an opportunity for University of Chicago postdocs to combine a high-quality research experience with a mentored teaching and training experience at two local partner institutions. Participants will have a Research Mentor at the University of Chicago, where they will develop research-related skills and Teaching Mentors at partner institutions, where they will experience classroom teaching and pedagogical training. Additional didactic activities and training are also part of a specialized curriculum through the Institute for Future Academics.

PI_NAMEs: RICE, PHOEBE A;SCHWARTZ, NANCY B (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TITLE: IRACDA at the University of Chicago

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


PHR: Project Narrative  Most disease-causing genetic variants do not directly affect genes, but rather the DNA sequences that control when and where genes function. This project introduces a new method to measure the activities of these control sequences, along with a quantitative framework for using the resulting data to predict the effects of genetic variation in these sequences.

PI_NAMEs: COHEN, BARAK A (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Affect;Affinity;Amacrine Cells;Astrocytes;billboard;Binding Sites;Biological Assay;Biophysics;Brain;cell type;Cells;combinatorial;Data;Dependence;Disease;DNA;DNA Sequence;Free Energy;Gene Expression Profile;gene function;Genes;genetic variant;Genetic Variation;Genome;Genomics;Goals;Grant;Heritability;Human Genome;in vivo;infancy;Libraries;Logic;Measures;Methods;Modeling;Muller's cell;Mus;Neurons;novel;Oligodendroglia;promoter;Regulation;Reporter;Reporter Genes;Research;Retina;retinal rods;Site;Specific qualifier value;Specificity;Testing;Thermodynamics;Tissues;training data;transcription factor;Untranslated RNA;Variant;Work

PROJECT_TITLE: Analysis of combinatorial cis-regulation in synthetic and genomic promoters

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-V(02)M]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health

ORG_CITY: LAS VEGAS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: NARRATIVE This study is designed to enhance understanding of the measurement of experiences, roles and dynamics for sexual and gender minority (SGM) caregivers of persons living with Alzheimer’s disease and related dementias (ADRD). The study will identify existing domains and develop new measures of ADRD caregiving, test and validate these measures, and ensure measures are inclusive and accurately capture caregiving constructs and experiences of diverse SGM ADRD caregivers. Our long-term goals are to ensure that SGM ADRD caregivers are included in ongoing ADRD caregiving research and measures, and that future interventions can support all ADRD caregivers and their care recipients.

PI_NAMEs: ANDERSON, JOEL G.;DOWLING, NORCA MARITZA;FLATT, JASON DANE (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Adult;Alzheimer's disease caregiver;Alzheimer's disease related dementia;asexual;Behavioral;Biological;care recipients;caregiver strain;Caregivers;caregiving;caregiving research;Caring;Child;cisgender;cognitive interview;Communities;community based participatory approach;community partners;community-level factor;Data;dementia care;Dementia caregivers;dementia caregiving;design;Development;digital media;Dimensions;disability;Discrimination;Effectiveness;Emotional;Ensure;ethnic diversity;experience;Family;Family member;field study;Financial Hardship;Focus Groups;Friends;Future;Goals;Health;health disparity;health equity promotion;Heterosexuals;Improve Access;indexing;Individual;informal caregiver;intersectionality;Intersex;Intervention;Interview;Knowledge;Lesbian Gay Bisexual Transgender Queer;Lived experience;Measurement;Measures;Medical;member;Mental Depression;Methods;Modeling;Moods;Nature;offspring;Outcome;Persons;poor health outcome;Process;Psychological Factors;Quality of life;racial diversity;recruit;Registries;Research;Research Personnel;response;Role;Sampling;Services;Sexual and Gender Minorities;social;social stigma;Spouses;Stress;Structure;support network;surrogate decision making;Testing;theories;Time;Victimization

PROJECT_TITLE: Enhancing Measurement and Characterization of Roles and Experiences of Sexual and Gender Minority Caregivers of Persons living with Alzheimer's Disease and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-A(56)R]


NIH_SPENDING_CATS: Aging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: The size of heart attacks and patient survival even following successful current treatment is worse in elderly patients. Using mouse models of this problem, we will test a promising new application of a currently used drug to reduce heart injury during the heart attack. If successful, this new use of an approved drug could be fast-tracked toward clinical use.

PI_NAMEs: LESNEFSKY, EDWARD J (contact);LI, JI

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acceleration;Acute;adenylate kinase;Adult;aged;Aging;Amobarbital;Attenuated;Autophagocytosis;Biogenesis;Cardiac;cardiac aging;cardioprotection;Cardiovascular Diseases;Cell Death;Clinical;clinical translation;Complex;Cytoprotection;Development;Dose;Drug Kinetics;Drug usage;Elderly;Electron Transport;Heart;heart damage;heart dimension/size;Heart failure;Heart Injuries;Heart Mitochondria;high risk;Impairment;improved outcome;In Vitro;in vivo;Infarction;inhibitor;Injury;Intravenous;Ischemia;Knockout Mice;Mediating;Metabolic;Metformin;Mitochondria;mitochondrial permeability transition pore;mouse model;Mus;Myocardial;Myocardial Infarction;myocardial injury;Non-Insulin-Dependent Diabetes Mellitus;older patient;Oral;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phenocopy;Phosphotransferases;Production;programs;Recovery;repaired;Reperfusion Injury;Reperfusion Therapy;Role;Scaffolding Protein;Signal Transduction;small molecule;Stress;Testing;Therapeutic;Therapeutic Intervention;Time;treatment optimization

PROJECT_TITLE: Metformin Therapy for Ischemic Insult and Reperfusion Injury in Aging

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences;Rehabilitation;Stroke

ORG_CITY: WASHINGTON

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PUBLIC HEALTH RELEVANCE: Public Health Relevance Statement Difficulty communicating (aphasia) is one of the most common and debilitating results of left-hemisphere stroke. While aphasia symptoms are highly variable and recovery is difficult to predict, stroke size and location are significant determinants of outcomes. Research that leads to a more complete characterization of how stroke lesions affect residual brain function over the course of recovery will lead to a better understanding of the brain-behavior relationship in aphasia and has the potential to inform clinical decision-making in aphasia neurorehabilitation.

PI_NAMEs: DEMARCO, ANDREW T (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Affect;Algorithms;Anatomy;Aphasia;aphasia recovery;Architecture;Area;Award;behavior measurement;Behavioral;behavioral outcome;Biological;biomarker development;Blood Vessels;Brain;brain behavior;Characteristics;Chronic;chronic stroke;Clinical;clinical decision-making;cohort;Communication difficulty;Data;Data Set;Deafferentation procedure;Diagnosis;Distant;Exhibits;experience;Functional disorder;Functional Magnetic Resonance Imaging;Goals;imaging modality;improved;Individual;Knowledge;Language;Lead;Left;Length;Lesion;Location;Longitudinal Studies;longitudinal, prospective study;Machine Learning;machine learning algorithm;Maps;Measures;Mentors;Modeling;multimodality;National Institute on Deafness and Other Communication Disorders;neural correlate;neurobiological mechanism;neuroimaging;neurological rehabilitation;neuromechanism;Neuronal Plasticity;Outcome;Pattern;Performance;Persons;Phase;Physiology;post stroke;programs;public health relevance;Recovery;Reproducibility;Research;Residual state;Resolution;Rest;Sample Size;Scanning;Severities;Signal Transduction;Source;spatiotemporal;Specific qualifier value;Strategic Planning;Stroke;stroke recovery;stroke survivor;stroke-induced aphasia;Structure;Symptoms;Testing;Time;tool;Training;white matter

PROJECT_TITLE: Functional anomaly mapping of aphasia recovery


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Human Genome;Prevention

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Clonal hematopoiesis, a highly prevalent condition in the elderly, arises from somatic mutations that endow a proliferative advantage to hematopoietic cells and imparts a substantial risk of coronary heart disease. Of the diverse mutations that promote clonal hematopoiesis, JAK2V617F and PPM1D mutations have been associated with DNA damage. The studies proposed here will elucidate the consequences of macrophage DNA damage and Ppm1d mutations on atherosclerosis.

PI_NAMEs: FIDLER, TREVOR PERAWASKIN LARAMEE (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: 8-hydroxy-2'-deoxyguanosine;Acceleration;Age;Antibodies;Area;Arterial Fatty Streak;Arteries;atherogenesis;Atherosclerosis;Awareness;Bar Codes;Bioinformatics;Blood Cells;blood fractionation;Bone Marrow;Bone Marrow Cells;Bone Marrow Transplantation;Cancer Patient;cancer survival;Cardiovascular Diseases;cardiovascular disorder risk;CASP1 gene;Caspase;Cell Death;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;chemotherapy;Clonal Expansion;Collaborations;Coronary;Coronary heart disease;Development;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Repair;DNA Repair Gene;ds-DNA;Elderly;Endowment;Environment;Epitopes;Etiology;extracellular;gain of function;Genes;genetic variant;Goals;Heart Diseases;Hematopoiesis;Hematopoietic;Histology;Human;Immune;improved;indexing;Inflammasome;Inflammation;Inflammatory;Interleukin-1;Interleukin-1 beta;Interleukin-1 Receptors;Knock-out;Knowledge;Lead;Learning;Lesion;Macrophage;Mentors;Metabolism;Minority;Modeling;mouse model;Mus;mutant;Mutate;Mutation;Myelogenous;Myeloid Cells;Myocardial Infarction;Necrosis;novel;oxidation;oxidative DNA damage;Pathway interactions;Patients;Phase;Phenotype;Phosphoric Monoester Hydrolases;Population;premature;prevent;programs;Proliferating;Protein phosphatase;PTPRC gene;Reactive Oxygen Species;replication stress;Reporting;Research;Research Personnel;Resolution;response;Risk;Risk Factors;Role;Signal Transduction;single-cell RNA sequencing;skills;Smooth Muscle Myocytes;Somatic Mutation;Source;Stroke;targeted treatment;Technology;Testing;Thinness;TP53 gene;Training;Transcript;transcriptome;transcriptome sequencing;Transgenic Organisms;Transplantation;Variant;Vascular Smooth Muscle

PROJECT_TITLE: Mechanisms of Atherogenesis in Clonal Hematopoiesis


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BOSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: Clostridioides difficile is a major nosocomial pathogen that costs the US health care system ~$5 billion to treat each year. Since spore germination is required for C. difficile to initiate infection, elucidating the molecular mechanisms by which C. difficile senses bile acids and co-germinants to activate spore germination could inform the development of strategies for preventing C. difficile disease and recurrence.

PI_NAMEs: SHEN, AIMEE  (contact)

PROJECT_TERMS: Affinity;Amino Acids;Bacteria;Bacterial Spores;Bile Acids;Binding;Binding Proteins;Biochemical;Bypass;Cell Physiology;Clostridium difficile;Complex;cost;Data;Development;Disease;Enzymes;Equilibrium;Family;flexibility;Funding;genetic analysis;genetic approach;Genetic Screening;Germination;Healthcare Systems;Heterodimerization;Homodimerization;In Vitro;Infection;insight;Life;LytA enzyme;Mediating;Membrane;Modeling;Molecular;Mutation;Mutation Analysis;N-terminal;novel;Nutrient;pathogen;Peptide Hydrolases;premature;prevent;protein function;protein protein interaction;Proteins;receptor;Recurrence;Regulation;Reproduction spores;response;Role;Serine Protease;Signal Transduction;Signaling Molecule;small molecule;Structure;Subtilisins;Testing;Work

PROJECT_TITLE: Regulation of Spore Germination in Clostridioides difficile

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative The acute inflammatory response is the body’s first line of defense to invading pathogens or injury, which naturally resolves with the biosynthesis and actions of specialized pro-resolving mediators (SPMs). The goal of this proposal is to elucidate the mechanisms that govern resolution programs in the bone marrow and to map the role of SPMs in directing hematopoietic stem and progenitor cell (HSPC) function(s) during homeostasis and infection to promote host defense using cutting-edge technologies. The improvement of our understanding of the molecular mechanisms that govern HSPC functions and their environment has direct clinical relevance by providing needed pre-clinical results for new therapeutic approaches that may help prevent complications associated with transplantation, such as infections and diseases with uncontrolled inflammation.

PI_NAMEs: LIBREROS, STEPHANIA  (contact)

PROJECT_TERMS: Acceleration;Acute;Adult;Agonist;Anabolism;Applications Grants;Autacoids;Blood Cells;Bone Marrow;Bone Marrow Cells;career development;CD14 gene;CD34 gene;CD59 Antigen;Cell Cycle;Cell Differentiation process;Cell Separation;Cells;clinically relevant;Coin;Collaborations;Colony-Forming Units Assay;Containment;Cytometry;Development Plans;Disease;Distal;Environment;Enzymes;Escherichia coli;Essential Fatty Acids;experience;Faculty;Future;Genomics;Goals;granulocyte;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic stem cell fate;Hematopoietic stem cells;Homeostasis;Hospitals;Host Defense;Host Defense Mechanism;Human;Hypoxia;Immune;Impairment;improved;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;insight;Institution;International;Invaded;Laboratories;Laboratory Research;Leukocytes;Leukotrienes;life span;lipid mediator;Lipids;lipoxin B4;Lipoxins;Lipoxygenase;Liquid Chromatography;Macrophage;Maps;Mass Spectrum Analysis;Measures;Mediator;medical schools;Mentors;Mentorship;metabolomics;microbial;Molecular;monocyte;Mus;Myeloid Cells;Myeloid Progenitor Cells;Myelopoiesis;nanomolar;neutrophil;novel;novel therapeutic intervention;Organ;Organism;Oxygen;pathogen;Pathologic;Pathway interactions;peripheral blood;Peritoneal;Phagocytes;Phase;Phenotype;Physiological;Population;Positioning Attribute;pre-clinical;pressure;prevent;Production;professor;programs;Proliferating;Prostaglandins;Regulation;Research Proposals;Resolution;response;Role;Scientist;self-renewal;Side;Signal Transduction;single cell technology;single-cell RNA sequencing;Site;skills;stem cell biology;stem cell differentiation;stem cell function;stem cell niche;stem cell proliferation;Structure;tandem mass spectrometry;Technology;Testing;Time;Tissues;transcriptome sequencing;Transplantation;United States National Institutes of Health;Whole Blood;Woman

PROJECT_TITLE: Bone Marrow Functions of Novel Pro-Resolving Mediators


NIH_SPENDING_CATS: Asthma;Clinical Research;Lung

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative: Asthma is a highly prevalent disease composed of different clinical and biologic phenotypes with variable responses to therapy. We have previously described the presence of Type 1 inflammation in approximately 30-40% of asthma patients which associates with more severe disease and poor response to therapy. This project seeks to expand our understanding of the of the pathologic mechanisms underlying this phenotype as well as the clinical manifestations over time.

PI_NAMEs: GAUTHIER, MARC  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Adrenal Cortex Hormones;Adult;Affect;airway epithelium;airway hyperresponsiveness;airway obstruction;Antigens;Asthma;asthma model;asthmatic;asthmatic patient;Automobile Driving;Award;Bioinformatics;Biological;Biological Markers;Biological Products;Biological Response Modifier Therapy;biomarker development;Biopsy;Bronchoalveolar Lavage;Bronchoscopy;CCR5 gene;Cells;chemokine;Clinical;Clinical Data;clinical effect;cohort;Critical Care;CXCL10 gene;CXCR3 gene;cytokine;Data;Data Set;Development;Disease;disorder control;Eosinophilia;Epithelial Cells;Epithelium;FDA approved;Fostering;Future;High Prevalence;Human;Hypersensitivity;Immune;improved;Inflammation;Inflammatory;inflammatory marker;Infrastructure;inhibitor;insight;Interferon Type II;Interferons;International;Link;Lung;Machine Learning;Maintenance;mast cell;Measures;Mediating;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentorship;mouse model;multidisciplinary;Mus;Natural History;Neutrophilia;novel;novel therapeutics;Outcome;Participant;Pathologic;Pathway interactions;Patients;Persons;Phenotype;Physicians;Prevalence;professor;programs;Pulmonary Inflammation;receptor;recruit;Research;Research Technics;Resistance;response;Role;Sampling;Scientist;Severity of illness;Signal Transduction;skill acquisition;skills;Sputum;Steroids;targeted treatment;Time;tissue resident memory T cell;Tissues;Training;transcriptome sequencing;translational physician;Translational Research;treatment response;Universities;Work

PROJECT_TITLE: An Alternative Pathobiology underlying Severe Asthma

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Mental Health;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: LEAFLABS, LLC

PHR: PROJECT NARRATIVE Electrophysiological recording systems allow direct observation of neural activity in animal subjects. This facilitates the study of crucial neuroscientific topics such as development, learning and memory, and cognition, as well as brain diseases such as Alzheimer’s, epilepsy, Parkinson’s, and depression. LeafLabs’ tools for performing high-channel count electrophysiology experiments in freely-moving rodents will allow researchers to collect and interpret neural data at a large scale, with few experimental constraints to environment complexity or the types of naturalistic behaviors studied.

PI_NAMEs: SHERWOOD, JOHN L (contact)

PROGRAM_OFFICER_NAME: DURKIN, JACLYN MARIE

PROJECT_TERMS: Address;Alzheimer's Disease;analog;Animal Behavior;Animals;Architecture;Behavior;Behavioral;behavioral study;Bluetooth;Brain;Brain Diseases;BRAIN initiative;Cells;Cognition;Complex;cost;Custom;Data;data acquisition;design;Development;digital;driving force;effective therapy;Electrodes;Electrophysiology (science);Engineering;Ensure;Environment;Epilepsy;experimental study;Funding;Generations;Goals;Head;Image;improved;in vivo;Individual;innovation;Learning;light weight;Mammals;manufacture;Memory;Mental Depression;millisecond;neural;neural circuit;neural stimulation;Neurobiology;Neurofibrillary Tangles;Neurologic;neuronal circuitry;Neurons;Noise;novel;Parkinson Disease;Performance;Peripheral;Phase;Pilot Projects;Population;power consumption;Production;real time monitoring;research facility;Research Personnel;Resolution;Rodent;Sampling;Scientific Inquiry;sensor;Services;Silicon;Small Business Innovation Research Grant;Sorting;Stream;Surface;System;Techniques;Technology;Telemetry;Testing;theories;Thinness;Time;Tissues;tool;Weight;Willow;wireless;wireless fidelity;Wireless Technology;Writing

PROJECT_TITLE: Untethered high channel count electrophysiology for freely-moving animals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Worldwide, Gestational Diabetes Mellitus (GDM) is surging, increasing health complications for mothers and infants. Therefore, it is necessary to improve our molecular understanding of GDM to prevent better and treat this pregnancy condition. In this context, studying the role of nutrient-sensing O-GlcNAc modification is highly significant not only to tie environmental influences on GDM development but also to explore new treatment options.

PI_NAMEs: OLIVIER-VAN STICHELEN, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Affect;Animals;Beta Cell;Biological Markers;Blood Glucose;Brain;Cardiovascular Diseases;Cell secretion;Cells;Child;Clinical;Complications of Diabetes Mellitus;Cytoplasmic Protein;Data;design;detection of nutrient;Development;Diabetes Mellitus;diabetic;Diet;Disease;disorder prevention;effective therapy;Endocrine;Enzymes;Fetal Development;Fetal Macrosomia;Functional disorder;Gestational Diabetes;Glucose;Grant;Health;healthy pregnancy;Hepatocyte;Hormonal;Hormonal Change;Hormone secretion;Human;Impairment;improved;in vivo;Infant;innovation;Insulin Resistance;insulin secretion;insulin signaling;Knowledge;Lead;Literature;Location;Malignant Neoplasms;Mammals;Mass Spectrum Analysis;Measures;Metabolic Diseases;Mitochondrial Proteins;Modification;Molecular;Molecular Profiling;Molecular Target;Mothers;Mus;National Institute of Child Health and Human Development;Nerve Degeneration;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear Proteins;Nutrient;Obesity;Outcome Study;Pathologic;peptide O-linked N-acetylglucosamine-beta-N-acetylglucosaminidase;Phase;Physiological;Physiology;Pituitary Gland;Pituitary Hormones;Placenta;Placental Hormones;Plasma;Post-Translational Protein Processing;Pregnancy;prevent;Prevention;programs;Proteins;Research;response;Role;Serine;Signal Pathway;Signal Transduction;Somatotropin;Symptoms;Testing;Threonine;Time;Treatment Protocols;trophoblast

PROJECT_TITLE: Placental Hormones and O-GlcNAcylation in Gestational Diabetes

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Patient Safety;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Closing critical gaps in the understanding of health outcomes for older adults with neurological disorders by clarifying the role of drug-drug and drug-disease interactions and systemic disparities in care processes may inform basic science and clinical practice research the development of care models able to achieve health equity. The proposed K24 research and training program will also expand the candidate's ability to effectively mentor trainees approaching neuroaging POR from multiple disciplines and clinical specialties. Ultimately, this project will help the candidate achieve her long term goals of (1) being a thought leader in neuroaging POR at the intersection of epidemiology and health services research, (2) producing new scientific knowledge that improves care and outcomes for older adults with neurological diseases, and (3) mentoring the next generation of leaders in multidisciplinary neuroaging POR.

PI_NAMEs: WILLIS, ALLISON  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: access disparities;Address;Advisory Committees;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;analytic epidemiology;Anti-Cholinergics;Basic Science;Biological;Biometry;Caliber;care delivery;care outcomes;career;Caring;Chronic;chronic neurologic disease;Clinical;clinical practice;cognitive function;collaborative environment;Coupled;Data Analyses;Data Collection;Data Set;Dementia;dementia risk;Dementia with Lewy Bodies;design;Development;Discipline;Disease;Disparity;disparity reduction;Dopaminergic Agents;drug development;Drug Exposure;Drug Interactions;Drug Prescriptions;Educational Background;Elderly;Electronic Health Record;Environment;Epidemiology;epidemiology study;Epilepsy;Equity;Evaluation;Event;evidence base;Exposure to;Funding;Geriatrics;Goals;Guidelines;Health;health care disparity;health care service utilization;Health Disparities Research;health disparity;health equity;health service use;Health Services;Health Services Research;Health system;high risk;Huntington Disease;Impaired cognition;improved;Individual;Informatics;Infrastructure;innovation;insight;Institution;Intellectual functioning disability;International;Investigation;K-Series Research Career Programs;Knowledge;Learning;Lewy Body Dementia;Link;Medical;medical specialties;Medicare claim;Mentors;Mentorship;Methodology;Mid-Career Clinical Scientist Award (K24);mild cognitive impairment;Minority;mixed dementia;Modeling;Monitor;Motor;multidisciplinary;Multiple Sclerosis;neighborhood disadvantage;Neighborhoods;Nervous System Disorder;Neurologic;Neurologic Dysfunctions;Neurologist;Neurology;neuroprotection;next generation;novel;Observational Study;older adult;Outcome;outcome disparities;Parkinson Disease;Parkinson's Dementia;patient oriented;patient oriented research;Patients;Pennsylvania;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacology;Pharmacotherapy;poor health outcome;Population;Process;programs;prospective;Psychiatry;Public Health;Quality of Care;recruit;Reporting;Research;research and development;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Risk;Role;Safety;Sampling;social factors;success;System;Time;Training;Training Programs;Traumatic Brain Injury;treatment adherence;Treatment outcome;Universities

PROJECT_TITLE: Midcareer Development Award in Neuroaging and Geriatric Pharmacoepidemiology Research

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Behavioral and Social Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome

ORG_CITY: AUSTIN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative Genome-Wide Association Studies (GWAS) are generated at unprecedented scale, with millions of people enrolled—presenting unprecedented opportunity to learn about the map between genetics and vulnerability to disease and other complex traits, but as the name suggests, GWAS only generate correlation data—and numerous challenges follow. We will develop statistical approaches to learn about the genetics and evolution of complex traits in humans, using biobank and other data. Our central aim is to understand the causes for the poorer performance of disease predictors based on GWAS data, thereby making a pivotal step towards a more equitable application of the genomic revolution.

PI_NAMEs: HARPAK, ARBEL  (contact)

PROJECT_TERMS: Adoption;biobank;Complex;Complex Genetic Trait;Cues;Data;Data Correlations;Disease;Enrollment;Environment;Equity;Evolution;Family Study;gene environment interaction;Genetic;genetic architecture;genetic predictors;Genetic Research;Genetic Variation;genome wide association study;genomic predictors;Genomics;Health;Human;Immunity;Learning;Link;Maps;Marriage;Methods;Modeling;Names;Natural Selections;novel strategies;Performance;Persons;Phenotype;Population Genetics;portability;Predisposition;Recording of previous events;Research;response;Sampling;social;Statistical Methods;theories;tool;trait;Underrepresented Populations;Underserved Population;Variant;Work

PROJECT_TITLE: Making Genomic Prediction of Complex Disease Equitable

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative: The mission of the UCSF Biomedical Sciences training program is to train a diverse generation of new leaders in the biomedical sciences, equipping them with the knowledge and skills to perform rigorous and reproducible research that will uncover the biological mechanisms that underlie human health and disease. We prepare trainees for success in a variety of careers in which they will contribute to the biomedical scientific enterprise. Society will benefit from the discoveries and treatments that will result from the training of scientists who are motivated and able to apply fundamental and patient-based research approaches to advance human health.

PI_NAMEs: ERLEBACHER, ADRIAN ;SIL, ANITA  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Science;Training

PROJECT_TITLE: Predoctrol Training in Biomedical Sciences

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE The multidisciplinary UAB Immunology T32 Training Program, “Immunologic Diseases and Basic Immunology”, is focused on training highly motivated predoctoral students and PhD and MD graduates in the fields of translational and fundamental immunology. Our trainees are selected for their commitment to research and academic medicine. The success of their future investigator-initiated studies, which are best represented by R01-caliber projects, requires the development of skilled creativity and the ability to identify and achieve scientific goals of significance to the biomedical research enterprise.

PI_NAMEs: HARRINGTON, LAURIE ELLEN (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Immune System Diseases;Immunology