FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

ORG_STATE: CA

PHR: Project Narrative This research training plan will address the knowledge gaps in the development and progression of the most common inherited cardiac disease, Hypertrophy Cardiomyopathy (HCM). Several single point mutations in b- myosin heavy chain (MYH7), myosin-binding protein C (MYBPC3) and cardiac troponin (cTn) have been associated with HCM and increased contractility at the organ level; however, the kinetics at the molecular level remain unclear, as different mutations can result in increased, decreased, or unchanged myosin force production. This research will focus on changes in biochemical signaling of HCM mutant cardiomyocytes, specifically through the Hippo pathway, which is known to be a homeostatic regulator of cellular size, a hallmark of HCM.

PI_NAMEs: CHIRIKIAN, ORLANDO  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Actins;Affect;beta-Myosin;Biochemical;Biomechanics;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;Cell Nucleus;Cells;Clinical;Cytoplasm;Cytoskeleton;Desmin;Development;Disease;disease phenotype;Elements;Environment;Event;Exhibits;extracellular;Fibrosis;Generations;genetic regulatory protein;Growth;Heart;Heart Diseases;Homeostasis;human induced pluripotent stem cells;Hypertrophic Cardiomyopathy;Hypertrophy;In Vitro;Individual;induced pluripotent stem cell derived cardiomyocytes;Inherited;insight;Kinetics;Knowledge;Label;Lead;Measures;mechanical signal;Mechanical Stress;Mechanics;Mediating;Microtubules;Modeling;Molecular;Morphology;mutant;Mutation;Myosin ATPase;Myosin Heavy Chains;myosin-binding protein C;novel;Nuclear;Nuclear Protein;optogenetics;Organ;Organ Size;Pathologic;Pathway interactions;Pharmaceutical Preparations;Phenotype;Point Mutation;Production;Protein Dynamics;Proteins;Regulation;Research;Research Training;response;Role;Signal Transduction;Signaling Protein;Stress;Testing;Therapeutic;tool;Traction Force Microscopy;transcriptome;transmission process;Troponin

PROJECT_TITLE: The Role of Yes Associated Protein (YAP) in Hypertrophic Cardiomyopathy


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: FAMILY MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE American Indians suffer from the highest rate of cardiovascular disease in the nation and efforts to address cardiovascular disease prevention amongst American Indians are few and less effective compared to the general population. The goal of this project is to partner with the Cherokee Nation to co-create an intervention to prevent cardiovascular disease based on over 30 years of successful interventions that facilitate Cherokee-specific cultural learning. Results from this project will lead to potentially new methods to reduce the morbidity and mortality of cardiovascular disease using an indigenous and community informed perspective.

PI_NAMEs: LEWIS, MELISSA  (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Adult;Affect;Age;aged;American Heart Association;American Indian Population;American Indians;Behavior;Blood Pressure;Body mass index;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;career;career development;Cause of Death;Cessation of life;Cherokee Indian;Cherokee Nation;Collaborations;commune;Communities;community based participatory research;community based research;Community Participation;community partners;cultural values;Data Collection;Development;Development Plans;Diet;diet and exercise;disease disparity;Disparity;Education;Educational process of instructing;effectiveness trial;Enrollment;Ensure;Evaluation Studies;evidence base;Excision;Exercise;exercise regimen;experience;federal policy;flexibility;Focus Groups;Foundations;Funding;Future;General Population;Generations;Goals;Health;health equity;healthy lifestyle;high risk population;Hypertension;improved;Indigenous;informant;innovation;Intervention;Interview;Knowledge;Language;Learning;Life Style;lifestyle intervention;member;Mental Depression;Mental Health;Mentors;Methods;Minority Groups;Morbidity - disease rate;mortality;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Obesity;Oklahoma;Outcome;Participant;Pathology;Personal Satisfaction;Persons;Pharmaceutical Preparations;Physical activity;Pilot Projects;pilot test;Population;Positioning Attribute;Prediabetes syndrome;premature;Prevalence;prevent;Prevention;Prevention program;Primary Prevention;Principal Investigator;programs;Protocols documentation;Public Health;Randomized, Controlled Trials;Recording of previous events;Reporting;Research;Research Activity;research and development;Research Methodology;Research Personnel;Research Project Grants;Risk Factors;Science;sedentary lifestyle;skills;Smoking;social;social culture;Social support;Stress;success;successful intervention;Surveys;Time;Training;trend;tribal Nation;Tribes;Unhealthy Diet;Work;Writing;young adult

PROJECT_TITLE: Adaptation and implementation of a Cherokee-based participatory research project to reduce CVD risk


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Aging;Atherosclerosis;Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Climate-Related Exposures and Conditions;Clinical Research;Emphysema;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Prevention;Pulmonary Fibrosis

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Chronic obstructive pulmonary disease (COPD) and emphysema are, jointly, the fourth leading cause of death in the United States and third leading cause globally. The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study found that emphysema measured quantitatively on computed tomography (CT) is common and morbid among older adults in the general population; however, standard measures underestimate the complexity of the disease. In this renewal, we hypothesize that machine-learned CT emphysema subtypes are distinct, have different causes and prognoses, and that distinguishing pathological emphysema from that resulting from normal aging with help the prevention and treatment of COPD and emphysema.

PI_NAMEs: BARR, R GRAHAM (contact)

PROGRAM_OFFICER_NAME: HU, TOM CHIH-CHUANG

PROJECT_TERMS: Age;aging population;ambient air pollution;Benign;Black Populations;Blood;Blood Cells;causal variant;Cause of Death;cell type;Cells;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;Copper;Data;Diffuse;Disease;disorder subtype;Dust;Elderly;Endothelium;Environmental Exposure;Environmental Risk Factor;Epidemiology;Epithelial Cells;Epithelium;Ethnic Origin;Ethnic Population;Evaluation;Gene Expression;Gene Expression Profile;General Population;Genetic Risk;genomic locus;Genomics;Hair follicle structure;heart function;Hospitalization;idiopathic pulmonary fibrosis;innovation;insight;Lung;Machine Learning;Measures;men;Methods;Minority;Molecular Analysis;mortality;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;Nasal Epithelium;non-smoker;normal aging;Nose;novel;Occupational Exposure;older adult;Oxygen;ozone exposure;Participant;Pathologic;Phenotype;Physiology;population based;Prevalence;Prevention;Prognosis;Pulmonary Emphysema;Pulmonary Fibrosis;Quantitative Trait Loci;Race;racial population;Reproducibility;Respiratory Disease;Risk;Risk Factors;Sampling;Scanning;Senility;sex;Smoker;Smoking;Smoking History;Spirometry;standard measure;Testing;Tetraodontidae;Therapeutic;transcriptome sequencing;United States;unsupervised learning;Vascular Diseases;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Precision phenotyping of emphysema in the elderly: the MESA Lung Study

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHIATRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Addressing the significant mental health burden of our modern society cannot be accomplished in the absence of meaningful scientific discovery by physician-scientists. The Emory Clinical Scientist Training Program (CSTP) addresses the critical shortage of well-trained physician-scientists in psychiatry by utilizing an innovative research training platform, grounded in state-of the-art clinical neuroscience research and addressing the primary need for intensive mentorship throughout psychiatry residency. In addition, the Emory CSTP provides research training and experiences to all psychiatry residents to nurture their interests in research and prepare them for a life-long practice of evidence-based medicine.

PI_NAMEs: GOLDSMITH, DAVID RYAN;MILLER, ANDREW H (contact);TREADWAY, MICHAEL TILGHMAN

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: ABCB1 gene;Accreditation;Active Learning;Address;Advisory Committees;Area;Award;base;Behavioral;Behavioral Sciences;career;career development;Clinical;Collaborations;collaborative environment;Communities;Community Psychiatry;Computing Methodologies;Data;Data Analyses;Dedications;design;Development;disadvantaged background;Disease;Disparity population;Doctor of Philosophy;Education;Education Projects;Educational Curriculum;Educational process of instructing;Elements;Endocrinology;Ensure;Ethics;evidence base;Evidence Based Medicine;Evidence based practice;experience;Exposure to;faculty support;Feedback;Fellowship;Fostering;Fright;fundamental research;Funding;Future;Generations;Goals;Grant;Immunology;improved;Individual;innovation;Institute of Medicine (U.S.);interest;Internet;K-Series Research Career Programs;Knowledge;Leadership;learning strategy;Manuscripts;meetings;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Modernization;Morehouse School of Medicine;National Institute of Mental Health;National Institute on Alcohol Abuse and Alcoholism;Neurobiology;neurodevelopment;neuroregulation;Neurosciences Research;novel;particle;patient oriented research;Physicians;Preparation;Process;professor;programs;Psychiatry;Public Health;Publishing;Qualifying;recruit;Reproducibility;Research;Research Activity;Research Design;research faculty;Research Personnel;Research Support;Research Training;Residencies;Resources;Science;Scientist;senior faculty;Series;skills;social neuroscience;Societies;Solid;Strategic Planning;success;Time;timeline;Training;training opportunity;Training Programs;Trauma;Underrepresented Minority;United States National Institutes of Health;Woman

PROJECT_TITLE: Emory Psychiatry Clinical Scientist Training Program (CSTP)


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric

ORG_DEPT: MISCELLANEOUS

PHR: Linking Science, Mathematics and Literacy for All Learners (LSM&L4AL) PROJECT NARRATIVE This project is focused on developing educational resources—multimodal STEM text sets—designed for middle school students to engage in and understand complex text. We will test the hypothesis that these resources, situated in life sciences topics, will result in improved diverse learners’ reading, mathematics, and scientific argumentation skills. These resources along with findings from the project will be disseminated widely and contribute to NIH’s and the nation’s overarching goal to “enhance the training of a workforce to meet the nation’s biomedical, behavioral and clinical research needs and especially of students from underserved communities.”

PI_NAMEs: FOLK, WILLIAM ROBERT;LANNIN, AMY A;VAN GARDEREN, DELINDA  (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: Achievement;Address;Age;Area;Attention;Behavioral Research;Behavioral Sciences;Biological Sciences;Biomedical Research;Books;career;Clinical Research;collaborative approach;Collection;Common Core;Community of Practice;Complex;Data;design;Development;disabled students;diversity and inclusion;Education;education planning;education resources;Educational Intervention;eighth grade;Engineering;English Language;Ensure;Evaluation;experience;Faculty;Funding;Goals;Graph;improved;innovation;Institution;Instruction;interest;Journals;Language;Language Development;Learning;Link;literacy;Location;mathematical learning;Mathematics;Measures;Medical;meetings;Middle School Student;Missouri;multimodality;National Institute of General Medical Sciences;Next Generation Science Standards;novel;Peer Review;Population;programs;Publications;Quantitative Evaluations;Reading;Reporting;Research;Research Personnel;Resources;Schools;Science;science teacher;Secondary Schools;Services;Site;skills;Societies;Source;Special Education;student participation;Students;synergism;teacher;Teacher Professional Development;Teaching Method;Testing;Text;tool;Training;underserved community;underserved students;United States National Institutes of Health;Universities;virtual;web site;Workplace

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: CA

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Palliative Care;Patient Safety;Physical Activity;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Although widely used and accepted in oncology practice to determine patient eligibility and physical tolerance for clinical trial participation, performance status—the single most powerful prognostic and key clinical decision-making tool across all solid tumor types—has one very significant limitation: its subjectivity. We propose to examine the association between continuously and objectively measured PA and clinician- assessed performance status scores, overall patient survival, and clinical outcomes of significance (i.e., symptom burden, quality of life measures, death, disease progression, treatment termination due to toxicity, hospitalizations and emergency room visits, and referral for supportive/hospice care). Our long-term goal is to increase objectivity in performance status assessments.

PI_NAMEs: OVERMAN, MICHAEL J;PETERSON, SUSAN K (contact);RAGHAV, KANWAL

PROGRAM_OFFICER_NAME: JENSEN, ROXANNE ELAINE

PROJECT_TERMS: Accelerometer;Advanced Malignant Neoplasm;Assessment tool;Cancer Patient;Caring;Cellular Phone;Cessation of life;Clinical;clinical decision-making;clinical trial protocol;Clinical Trials;cyber infrastructure;Data;Data Reporting;Devices;digital;Disease Progression;Eastern Cooperative Oncology Group;Eligibility Determination;Emergency department visit;evidence base;fitness;Funding;Goals;Guidelines;Health Personnel;Healthcare;Home;Home Care Services;Hospice Care;Hospitalization;Hour;improved;innovation;Karnofsky Performance Status;Link;Measurement;Measures;Medical Care Team;Methods;Monitor;Oncologist;Oncology;Outcome;Palliative Care;Patient Self-Report;Patients;Performance;Performance Status;Physical activity;Physical assessment;Physicians;predict clinical outcome;prognostic;prognostication;Quality Indicator;Quality of life;recruit;Research;risk stratification;sensor;Solid Neoplasm;standard of care;Standardization;Stratification;survival outcome;survival prediction;Symptom Burden;System;Systemic Therapy;Technology;Time;tool;Toxic effect;Validity and Reliability;Work;wrist worn device

PROJECT_TITLE: A technological approach for performance status assessment in advanced cancer patients


ADMINISTERING_IC: AA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: RICHARDSON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: PROJECT NARRATIVE: The experiments in this project will use an animal model of alcohol self-administration to study maladaptive changes in synaptic plasticity in specific prefrontal cortical networks that occur in the transition from goal-directed to compulsive alcohol drinking. Understanding the development of these changes is important as they are likely to contribute to cognitive deficits and impact the ability of the prefrontal cortex to regulate drug-seeking behavior.

PI_NAMEs: KROENER, SVEN  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: activity marker;Acute;Affect;alcohol availability;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol seeking behavior;Alcohol withdrawal syndrome;Alcohols;Amygdaloid structure;Animal Model;Animals;Automobile Driving;Back;Behavior;C57BL/6 Mouse;Cells;Chloride Channels;Chronic;Cognitive;cognitive change;Cognitive deficits;cognitive function;combinatorial;CREB1 gene;Cues;Data;Dendrites;Dependence;Development;drinking;drug of abuse;drug seeking behavior;Electrophysiology (science);executive function;experimental study;flexibility;Genetic Recombination;Glutamate Receptor;Glutamates;Goals;hippocampal pyramidal neuron;Immunohistochemistry;Impaired cognition;improved;Impulsive Behavior;incentive salience;Interneurons;Label;learning extinction;Light;Lithium Chloride;Medial;Modeling;Morphology;Motivation;Mus;N-Methyl-D-Aspartate Receptors;neuroadaptation;Neurons;novel;Nucleus Accumbens;optogenetics;Output;patch clamp;Pathway interactions;Pharmaceutical Preparations;Play;Population;postsynaptic;Prefrontal Cortex;presynaptic;problem drinker;Pyramidal Cells;receptor expression;receptor function;Receptor Up-Regulation;receptor upregulation;Relapse;relapse prediction;Reporter;Resistance;Resolution;response;Rodent;Role;Self Administration;Self Direction;Synapses;synaptic function;Synaptic plasticity;Taste aversion;Testing;Time;vapor;Vertebral column;Visualization;voltage clamp;Withdrawal;Work

PROJECT_TITLE: Synaptic changes in the medial prefrontal cortex in the development of compulsive alcohol drinking

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Prevention;Rare Diseases;Vaccine Related;Valley Fever

ORG_CITY: MADISON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE This proposal will investigate the mechanisms that underpin effective vaccination against the systemic fungal infection Coccidioidomycosis. A live attenuated vaccine strain of the fungus has been developed and is known to protect against lethal infection, following vaccine delivery intranasally. It is widely believed that local immunity is mobilized by the vaccine and this proposal will clarify the necessary elements required for establishing this vaccine immunity.

PI_NAMEs: KLEIN, BRUCE STEVEN (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Ablation;adaptive immunity;Address;Antigen-Presenting Cells;Antigens;Attenuated Vaccines;Black Populations;Blastomyces dermatitidis;Calcineurin;Canis familiaris;CD4 Positive T Lymphocytes;Cell Shape;Cells;Cellular Immunity;Coccidioides;Coccidioidomycosis;commercialization;CYP21A2 gene;cytokine;Data;dectin 1;Disease;draining lymph node;Early Mobilizations;Elements;Emerging Communicable Diseases;Emerging infection;Epithelial Cells;Epithelial Receptor Cell;Epithelium;Filipino;fungus;Genes;Genetic Polymorphism;Hispanic Populations;Human;Immunity;Immunodominant Antigens;Infection;infection rate;Inflammatory;Inflammatory Response;Inhalation;innovation;Kinetics;Knowledge;Label;Link;Lung;Lymphocyte;Lymphoid Tissue;M cell;Measures;Mediating;Memory;memory CD4 T lymphocyte;Methods;Microbe;Military Personnel;Morbidity - disease rate;mortality;Mucosal Immunity;mucosal vaccine;Mucous Membrane;Mus;Mycoses;Myelogenous;Myeloid Cells;Natural Immunity;next generation;NF-kappa B;novel;pathogen;Patients;Peptides;Peyer's Patches;Phenotype;PLCG2 gene;PPP3R1 gene;Pregnant Women;Prevention;priority pathogen;Process;Reagent;receptor;recruit;Reporting;Reproduction spores;Research;Resistance;Respiratory Mucosa;response;Role;Route;Signal Pathway;Signal Transduction;Structure of parenchyma of lung;Subunit Vaccines;Surface;T-Cell Development;T-Lymphocyte;Testing;Tissues;tool;trafficking;Training;transcriptome;Transgenic Mice;Translating;United States National Institutes of Health;uptake;Vaccination;vaccine delivery;vaccine trial;Vaccines;Work

PROJECT_TITLE: Mechanisms of vaccine immunity against coccidioidomycosis

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Hypoplastic left heart syndrome (HLHS) is a severe congenital heart defect that can lead to death of newborns within a week in the absence of surgical treatment. This R01 project aims to address how the aberrant intercellular communication between myocardium (cardiac muscle fibers) and endocardium (endothelial cells lining the interior of the heart) leads to HLHS using patient-derived induced pluripotent stem cells and CRISPR genome editing. Understanding how HLHS is developed would be pivotal to discover novel therapeutic treatment for this lethal disease.

PI_NAMEs: ZHAO, MINGTAO  (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: access restrictions;Address;Affect;Animal Model;Animals;aortic valve;aortic valve disorder;Aortic Valve Stenosis;ascending aorta;Cardiac;Cardiac Myocytes;cardiogenesis;Cell Line;Cells;Clinical;clinical phenotype;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Communication;congenital heart abnormality;Congenital Heart Defects;CRISPR/Cas technology;Data;Defect;design;Development;Disease;Electrophysiology (science);Elements;Embryo;Endocardium;Endothelial Cells;Endothelium;exosome;Gene Dosage;Generations;Genetic;Genetic Engineering;genome editing;Genotype;Growth;Heart;Heart Atrium;Heart Diseases;Human;human induced pluripotent stem cells;human stem cells;Hypoplastic Left Heart Syndrome;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;intercellular communication;Interruption;Knowledge;Lead;Left;Left ventricular structure;Link;Mediating;Mitral Valve;Molecular;Morphogenesis;mouse model;Muscle Fibers;Mutation;Myocardial;Myocardium;Neonatal Mortality;Newborn Infant;Nodal;notch protein;NOTCH1 gene;novel;novel therapeutics;Operative Surgical Procedures;patch clamp;Pathogenicity;patient derived induced pluripotent stem cells;Patients;prevent;Proliferating;Proteomics;Publishing;Running;Side;Signal Transduction;single-cell RNA sequencing;Small RNA;stem cell model;stem cells;Structural defect;Structure;Study models;System;transcriptome sequencing;Variant;Ventricular

PROJECT_TITLE: An integrated human stem cell model for elucidating myocardial-endocardial interactions in cardiac development and disease

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: The most common cause of renal failure in the United States (US) is diabetic kidney disease (DKD), which costs the US ~$20 billion annually. DKD is, therefore, a substantial medical and economic burden to the healthcare system. The goal of the proposed studies is to determine if potentiating the effects of a hormonal system that protects the cells forming the kidney’s filter prevents or slows progression of DKD. If successful, the treatment approach might be used to treat DKD in humans.

PI_NAMEs: SPURNEY, ROBERT  (contact)

PROJECT_TERMS: Albuminuria;Apoptotic;Atrial Natriuretic Factor;Atrial Natriuretic Factor Receptors;Binding;Brain natriuretic peptide;C-Type Natriuretic Peptide;Complement;cost;Cyclic GMP;Cytoprotection;Diabetic Nephropathy;Disease;Economic Burden;Endocrine system;Generations;Goals;Healthcare Systems;Human;In Vitro;in vivo;Injury;Insulin-Dependent Diabetes Mellitus;Kidney;Kidney Diseases;Kidney Failure;Knock-out;Knockout Mice;Medical;Modeling;mouse model;Mus;Natriuretic Peptides;Nitric Oxide;Nitric Oxide Synthase Type I;NPR2 gene;Pathogenesis;peptide analog;Peptide Receptor;Peptide Signal Sequences;Pharmaceutical Preparations;pharmacologic;Play;podocyte;prevent;protective effect;receptor;Receptor Inhibition;Renal glomerular disease;Role;Signal Transduction;Source;Stimulus;translational potential;United States;Wild Type Mouse

PROJECT_TITLE: Promoting podocyte protective cGMP signaling in diabetic kidney disease


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Infectious Diseases;Liver Disease;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Plasmodium parasites, which cause the disease malaria, still sicken and debilitate over 200 million people per year at great cost to health. In this proposal, we will specifically address the biology behind the elusive Plasmodium vivax hypnozoite, a dormant liver stage, that can reactivate days, months or even years after its initial infection of a host hepatocyte, leading to a relapse of blood stage disease. Understanding how to combat the clinically silent hypnozoite is vital in an arena of malaria elimination and eradication.

PI_NAMEs: VAUGHAN, ASHLEY M (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Address;Affect;Africa;Aminoquinolines;Anti-malarials;Area;Asia;Biological;Biological Assay;Biology;Birth Weight;Bite;Blood;Cell Separation;Cells;Central America;Chromatin;Climate;climate zone;Clinical;combat;cost;Culicidae;Development;Disease;dosage;drug standard;early pregnancy loss;Frequencies;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic Transcription;Geography;Glucosephosphate Dehydrogenase Deficiency;Half-Life;Health;Hepatocyte;Horns;Host Defense;Human;Immunofluorescence Immunologic;improved;in vivo;in vivo Model;Individual;Infant Mortality;Infection;infection risk;innovation;insight;Intervention;Intrinsic factor;Invaded;Investigation;knock-down;Knowledge;Lead;Life Cycle Stages;Link;Liver;Malaria;malaria infection;Methods;Modeling;Morbidity - disease rate;mouse model;Mus;next generation;novel;Oceania;Parasites;Pathway interactions;Persons;Pharmaceutical Preparations;Plasmodium;Plasmodium falciparum;Plasmodium vivax;Population;Pregnant Women;prevent;Primaquine;Process;Proteins;Regimen;Relapse;relapse prevention;Research;Residencies;RNA;Seasons;single cell analysis;single cell sequencing;South America;spatiotemporal;Sporozoites;Stimulus;Testing;transcriptomics;transmission process

PROJECT_TITLE: Uncovering the parasite and host determinants of Plasmodium vivax hypnozoite formation and development using single cell sequencing and human liver-chimeric mice

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ORG_DEPT: UROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Approximately half the patients treated with BCG, the only approved immunotherapy for non-muscle invasive bladder cancer, experience a recurrence or progression of the disease. Our goal is two-fold: First, to better understand the longitudinal local and peripheral immune response to repeated intravesical BCG exposures and second, to identify specific genetic and immunological factors that impact patients’ sensitivity or resistance to treatment with BCG. When successful this information will help identify potential new strategies for improving treatment with BCG as a single therapy or in combination with other immunotherapies.

PI_NAMEs: HOROWITZ, AMIR  (contact);SFAKIANOS, JOHN

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: anti-PD-L1;Antineoplastic Agents;Bacillus Calmette-Guerin Therapy;BCG Live;Binding;Bladder Neoplasm;Blocking Antibodies;Blood;Blood specimen;cancer diagnosis;cancer type;Carcinoma in Situ;CD8-Positive T-Lymphocytes;Cells;chemokine;Chronic;Clinical;Clinical Trials;Coculture Techniques;Combination immunotherapy;Complex;cytokine;Cytolysis;Cytometry;Data;Disease;Disease Progression;dosage;Dose;exhaust;exhaustion;experience;Exposure to;FDA approved;Financial Hardship;functional restoration;functional status;Genes;Genetic;Geographic Locations;Goals;Hematopoietic;high risk;Image;Immune;immune checkpoint;immune checkpoint blockade;Immune response;Immunofluorescence Immunologic;Immunologic Factors;immunological status;Immunotherapy;Improve Access;improved;In Vitro;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Interferon Type II;intravesical;Intravesical Instillation;Kinetics;KLRD1 gene;Link;Major Histocompatibility Complex;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Measures;Mediating;Modeling;Molecular Profiling;mouse model;Mycobacterium bovis;Natural Killer Cells;neoplastic cell;new therapeutic target;Newly Diagnosed;non-muscle invasive bladder cancer;novel;Organoids;Pathway interactions;Patient Care;Patients;PD-1 pathway;PD-1/PD-L1;PD-L1 blockade;Peripheral;peripheral blood;Phenotype;Population;predictive marker;Primary Neoplasm;profiles in patients;programmed cell death ligand 1;programmed cell death protein 1;Proteins;recruit;Recruitment Activity;Recurrence;Recurrent disease;Recurrent tumor;Regimen;Resistance;resistance mechanism;response;Role;Signal Transduction;spatiotemporal;Specimen;Stromal Cells;T-Lymphocyte;Technology;Testing;Therapeutic;therapy resistant;transcriptome sequencing;transcriptomics;tumor;tumor diagnosis;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Tissue;Tumor-Derived;Tumor-Infiltrating Lymphocytes;virtual;Work

PROJECT_TITLE: HLA-E and NKG2A define a novel immune checkpoint axis in non-muscle-invasive bladder cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Hypothalamic neuropeptides AgRP, NPY, and αMSH are powerful regulators of food intake, energy expenditure, and body weight; however, exactly how they impact downstream circuits to modify behavior and physiology has remained a knowledge gap in the understanding and treatment of the obesity epidemic. Biochemically, receptors to these peptides signal through the secondary messenger cAMP, but technological barriers have prevented real-time monitoring and manipulation of cAMP in behaving animals. This grant uses new tools to track, make, and degrade cAMP to understand: (i) how cAMP levels change over time following direct cAMP stimulation of feeding, (ii) how changing cAMP influences neuronal activity, and (iii) how natural, compartmentalized changes in cAMP affects local neuronal functions.

PI_NAMEs: ZHANG, XINGJIE  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Adenylate Cyclase;Adult;Affect;Animals;Axon;Behavior;Biochemical;Biochemical Process;Body Weight;Brain;career development;Cell Compartmentation;Cells;Cilia;Concentration Camps;Cyclic AMP;Data;Dendrites;design;Drug Delivery Systems;Eating;Electrophysiology (science);energy balance;Energy Metabolism;Engineering;experimental study;Fasting;feeding;Feeding behaviors;Felis catus;fluorescence lifetime imaging;Genetic study;Goals;Grant;Histology;Human;Hunger;Hypothalamic structure;Image;in vivo;in vivo imaging;Individual;Influentials;insight;Intraventricular;Knowledge;Learning;Light;Measurement;Measures;meetings;Mentors;Modeling;Molecular;Monitor;Morbid Obesity;Mus;Mutation;Nature;neuronal cell body;Neurons;Neuropeptides;novel;Obesity;Obesity Epidemic;obesity treatment;optical sensor;Optics;optogenetics;paraventricular nucleus;Partner in relationship;patch clamp;Pathway interactions;PDE4D3;Peptide Receptor;Peptide Signal Sequences;Peptides;Pharmacologic Substance;phosphoric diester hydrolase;Physiology;prevent;Production;programs;Protein Engineering;real time monitoring;receptor;receptor function;Research;Research Personnel;Satiation;Second Messenger Systems;sensor;Signal Transduction;skills;Slice;subcellular targeting;Synapses;Synaptic plasticity;Techniques;Technology;Testing;Time;Titrations;tool;Training;two-photon;Viral

PROJECT_TITLE: Competing effects of AgRP and POMC neurons on cAMP signaling in downstream neurons in vivo

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Project Narrative Our work suggests that activation of STING in chronic lymphocytic leukemia (CLL) cells is disadvantageous for their growth and survival. Further understanding the mechanisms of STING in regulating BCR degradation, apoptosis and chemoresistance in CLL will inform us of how STING agonists can be deployed as anti-CLL agents alone or in combination with inhibitors of the BCR signaling such as BTKi to treat CLL in the clinic.

PI_NAMEs: HU, CHIH-CHI ANDREW (contact);PINGALI, SAI RAVI KIRAN

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acceleration;Adjuvant;adult leukemia;Adverse effects;Agammaglobulinaemia tyrosine kinase;Agonist;Apoptosis;B-Cell Antigen Receptor;B-Cell Lymphomas;B-Lymphocytes;Binding;biomarker selection;cell growth;cell type;Cells;Cessation of life;Chemoresistance;Chronic;Chronic Lymphocytic Leukemia;chronic lymphocytic leukemia cell;Clinic;Clinical Trials;Combination immunotherapy;Complex;cytokine;Cytoplasm;cytotoxicity;Data;Databases;DNA;Drops;Endoplasmic Reticulum;Gene Activation;Gene Expression;gene repression;Genes;Genetic;Growth;Human;Human Characteristics;humoral immunity deficiency;Immune response;immunodeficiency;in vivo;Induction of Apoptosis;Inflammatory;inhibitor;Injections;Interferon Type I;Interferons;IRF3 gene;kinase inhibitor;large cell Diffuse non-Hodgkin's lymphoma;leukemic transformation;Lewis Lung Carcinoma;lung cancer cell;Lymphoma;Malignant - descriptor;Malignant Neoplasms;Mediating;Medical;Melanoma;Mitochondria;mouse model;Multiple Myeloma;Mus;Mutation;National Cancer Institute;novel;novel therapeutics;patient derived xenograft model;Patients;PD-1 blockade;pembrolizumab;Phosphorylation;Primary carcinoma of the liver cells;Production;Proteins;Radiation;Receptor Signaling;Resistance;Role;Sampling;Serine;Signal Transduction;Solid Neoplasm;Stimulator of Interferon Genes;T cell response;targeted treatment;TBK1 gene;Testing;Therapeutic;tumor;Tumor Immunity;Tyrosine Kinase Inhibitor;United States;Work

PROJECT_TITLE: Mechanisms of STING in malignant progression and therapy of CLL.


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

PHR: PROJECT NARRATIVE Early detection of subtle cognitive decline associated with developing Alzheimer's disease (AD) pathology is crucial for identifying individuals who are most likely to benefit from early interventions. In this innovative proposal, we leverage existing data from three cohort studies to examine novel measures from the widely-used story recall task, including lexical retrieval, serial position, and computational linguistic measures, and their associations with amyloid, tau, neurodegeneration, and progression to clinical impairment. By using existing data from multiple AD cohort studies, we can develop novel methodology for early detection without adding participant burden, and can contribute an improved understanding of the underlying mechanisms of memory and communication breakdowns in preclinical AD.

PI_NAMEs: MUELLER, KIMBERLY D (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Adult;Alzheimer disease detection;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Anterior;Area;Biological Assay;Biological Markers;Categories;Clinical;clinical diagnosis;Clinical Trials;Cognition;Cognitive;cognitive function;cohort;Cohort Studies;Communication;Computational Linguistics;Data;Data Set;Dementia;design;Detection;Development;digital;Digital biomarker;Discourse analysis;Disease;Early Diagnosis;Early Intervention;Episodic memory;Event;Image;Impaired cognition;Impairment;improved;Individual;Inherited;innovation;Investigation;Language;Learning;Left;lexical;lexical retrieval;Linguistics;Link;Liquid substance;Longitudinal cohort;Longitudinal cohort study;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Memory;memory process;Methodology;Methods;mild cognitive impairment;Modeling;Monitor;Names;Nerve Degeneration;novel;novel marker;Outcome;Outcome Measure;Participant;Pathology;Performance;Persons;Phase;Play;Positioning Attribute;Positron-Emission Tomography;pre-clinical;Process;Registries;Research;Research Priority;Resources;response;Retrieval;Risk;Role;Semantic memory;Semantics;Signal Transduction;Speech;Symptoms;System;tau Proteins;Temporal Lobe;Testing;Wisconsin

PROJECT_TITLE: Novel Story Recall Measures as Indicators of Cognitive Decline Associated with Alzheimer's Disease and Related Disorders Biomarkers: A Collaborative Study of Existing Data

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Cardiovascular;Clinical Research;Depression;Mental Health;Neurosciences;Palliative Care;Sleep Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE The number of DT-LVAD implants is rapidly growing, and linkages between change in sleep and changes in cognitive function, symptoms of anxiety and depression, and health-related quality of life following LVAD implant remain largely unknown. The proposed research will detail changes and uncover new connections between sleep quality, cognitive function, psychological symptoms and health-related quality of life, which have not been studied simultaneously in the LVAD population. Findings generated from this investigation will provide foundational knowledge for building a new program of research in symptom and symptom management science in advanced heart failure.

PI_NAMEs: ZHENG, TAO  (contact)

PROGRAM_OFFICER_NAME: LONG, SYLVIA ELISABETH

PROJECT_TERMS: actigraphy;Address;Anxiety;anxiety symptoms;Arousal;Attention;Auditory;Award;biobehavior;biomaterial compatibility;Cardiac Output;Caring;Clinical;Cognition;cognitive function;comorbidity;Data;Data Collection;Dedications;depressive symptoms;Destinations;Devices;doctoral student;Drowsiness;Elderly;Event;executive function;experience;Fellowship;Foundations;Fright;Future;Goals;Health;health related quality of life;Heart failure;Heart Transplantation;high risk;Home;Impaired cognition;Impaired health;Impairment;Implant;implantable device;implantation;Implantation procedure;improved;indexing;Individual;Individual National Research Service Award;Influentials;innovation;Intervention;Investigation;Israel;Knowledge;Language;left ventricular assist device;Life;Life Style Modification;Link;Literature;Measures;mechanical circulatory support;Mechanics;Medical;Memory Loss;Mental Depression;Mental Health;Methods;mortality;Neurobehavioral Manifestations;novel;Nursing Research;Operative Surgical Procedures;optimal treatments;Organ;Outcome;Patients;Persons;physical symptom;Physiological;poor sleep;Population;portability;Postoperative Pain;Postoperative Period;pre-doctoral;processing speed;Productivity;programs;prospective;psychologic;psychological distress;psychological symptom;Pump;Quality of life;Recovery;reduce symptoms;Refractory;Research;Research Personnel;Research Training;respiratory;Risk;Schedule;School Nursing;Science;Sleep;Sleep Disorders;Sleep disturbances;sleep onset;sleep quality;Space Perception;Specific qualifier value;Speed;Symptom Burden;symptom management;symptomatic improvement;symptomatology;Symptoms;Technology;Therapeutic;therapy development;Time;Training;Transplantation;Treatment Failure;Universities;verbal;visual memory;Visuospatial;Washington

PROJECT_TITLE: Sleep and Cognition after Left Ventricular Assist Device Implantation

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(81)]


NIH_SPENDING_CATS: Cancer;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: We aim to test and understand the mechanism of a FDA-approved anti-inflammatory drug called Singulair for blocking initiation and malignant transition of a human disease named polycythemia vera (PV). We have identified a key gene known as Alox5 in PV-initiating cells from which PV is derived. We found that the Alox5 pathway is critically required for PV-initiating cell survival and disease initiation, and Singulair blocks this pathway effectively, providing a novel strategy for treating PV patients, and also for preventing PV and disease relapse in some healthy individuals who have acquired PV-causing gene but have not developed clinical symptoms, in patients who are in remission but in danger of transitioning to acute leukemia, and in patients who received bone marrow transplantation but still have detectable leukemia cells.

PI_NAMEs: LI, SHAOGUANG  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Acute leukemia;Acute Myelocytic Leukemia;Affect;anti-cancer research;Anti-Inflammatory Agents;Arachidonate 5-Lipoxygenase;Asthma;beta catenin;Bone Marrow Transplantation;cancer stem cell;CD34 gene;Cell Survival;Cells;Cellular Assay;Chemical Agents;Clinical;clinical remission;clinically significant;Colon;curative treatments;Development;diabetic;Disease;Disease remission;Effectiveness;Engraftment;Esophagus;FDA approved;Foundations;gene function;Genes;genetic approach;Growth;Human;human disease;Immunocompromised Host;In Vitro;in vitro testing;in vivo evaluation;Individual;Inflammatory;Inflammatory Response;inhibitor;JAK2 gene;Knockout Mice;Leukemic Cell;Leukotriene Receptor;Leukotrienes;Link;Lipids;Liver;Lung;Malignant - descriptor;Malignant Neoplasms;Molecular;montelukast;Mus;Myeloid Cells;Myeloproliferative disease;Names;Neoplasms;New Agents;Non obese;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Pancreas;Pathway interactions;Patients;peripheral blood;Pharmaceutical Preparations;Phenotype;Play;Polycythemia Vera;prevent;Preventive treatment;receptor binding;Recurrent disease;Regulation;Relapse;Reporting;Residual state;Role;Severe Combined Immunodeficiency;Skin;Solid;Solid Neoplasm;stem cells;symptomatic improvement;Symptoms;Testing;Therapeutic Agents;Time;Transcript;tumorigenesis

PROJECT_TITLE: Targeting cancer stem cells in JAK2V617F induced neoplasm


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Our mitochondrial genome (mtDNA) holds instructions that make mitochondria the “powerhouses of the cell”, but there is growing awareness that mtDNA can also trigger autoimmune response and collateral damage. I will examine the molecular machines that control this yin and yang of mtDNA. Through the K99/R00 award, I will train towards becoming an independent academic investigator and discover basic mechanisms relevant for treating both mitochondrial and inflammatory diseases.

PI_NAMEs: RATH, SNEHA PRAKASH (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Address;age related;age related decline;Age related pathologies;Alzheimer's Disease;Autoimmune Diseases;Autoimmune Responses;Autophagocytosis;Award;Awareness;Bioenergetics;Biological;biological adaptation to stress;Biology;Biosensor;Blood;career;Categories;cell growth;Cell model;Cells;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Computer Analysis;Core Protein;CRISPR screen;Custom;Cytosol;Data;Dedications;density;design;Disease;Doctor of Philosophy;Drug Targeting;ds-DNA;Electron Transport;endosymbiont;Energy Metabolism;Equilibrium;Eukaryota;Evolution;experience;experimental study;Extravasation;Faculty;fitness;follow-up;Future;Genes;Genetic;Genetic Screening;Genetic study;Genome;genome-wide;Goals;Growth;Homeostasis;Human;Immune;immune function;immunogenic;Immunologic Surveillance;Immunologist;Immunology;Impairment;improved;Inflammatory;Institution;Instruction;interest;Interferons;Knock-out;Laboratories;Link;member;Membrane Potentials;Mentors;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial genome;Mitochondrial Matrix;mitochondrial membrane;Molecular;Molecular Machines;multiple omics;NADH;Natural Immunity;novel;Nuclear;Nucleotides;Ovum;Oxidation-Reduction;Parkinson Disease;Pathway interactions;Phase;PINK1 gene;post-doctoral training;Postdoctoral Fellow;programs;Proline;Prosthesis;Protein Import;Proteins;Publishing;Regulation;Reporter;Research;Research Personnel;Respiratory Chain;response;Role;screening;sensor;Signal Transduction;small molecule inhibitor;Stimulator of Interferon Genes;Stress;Syndrome;System;Systems Biology;Testing;theories;Therapeutic;therapeutic candidate;time use;Tissues;Training;Trypanosoma;United States National Institutes of Health;Work;Yeasts;Yin

PROJECT_TITLE: A Systems Approach to Discover Sensors and Regulators of the Mitochondrial Genome


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Lung;Pulmonary Hypertension;Rare Diseases

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The proposed research by Dr. Zhiyu Dai is aimed at understanding why some patients develop high blood pressure in the lungs (pulmonary hypertension). Pulmonary hypertension is a serious and progressive disease without a cure and with 5-year mortality as great as 50%. In particular, we are trying to understand a pulmonary hypertension causing gene called SOX17 and develop a new effective therapeutic strategy for the treatment of this devastating disease.

PI_NAMEs: DAI, ZHIYU  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Address;Animal Model;Animals;Apoptosis;Apoptotic;Blood Vessels;bone morphogenetic protein receptors;cdc Genes;Cell model;Cell Proliferation;Cell Separation;Cessation of life;congenital heart abnormality;Data;Development;Disease;DNA Sequence Alteration;Down-Regulation;E2F transcription factors;effective therapy;Endothelium;Enhancers;Failure;Functional disorder;Gene Mutation;Genes;Genetic Transcription;genetic variant;Heart;Heart Hypertrophy;Hypertension;improved;in vivo;innovation;knock-down;Lesion;Link;loss of function;loss of function mutation;Lung;Mediating;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Mutate;Mutation;novel;novel therapeutic intervention;Organ;Pathogenesis;Pathology;Patients;Phenotype;Predisposition;premature;primary pulmonary hypertension;Progressive Disease;Proliferating;promoter;pulmonary arterial hypertension;pulmonary artery endothelial cell;Pulmonary Hypertension;pulmonary vascular remodeling;Pulmonary Vascular Resistance;Rattus;Reporting;Repression;Research;Resistance;right ventricular failure;Role;Signal Transduction;SOX17 gene;Stress;Structure;Survival Rate;therapeutically effective;transcription factor;transcriptome sequencing;Transgenic Mice;translational potential;treatment strategy;Up-Regulation;Vascular remodeling;Western Blotting

PROJECT_TITLE: Role of Endothelial SOX17 Deficiency in the Pathogenesis of Pulmonary Hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Genetics;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

PHR: Project Narrative: Proposed work will develop a low-cost, point-of-care test to; 1) identify individuals exposed to radiation from non-exposed population; 2) qualitatively determine the absorbed dose of radiation in the affected group; 3) Predict the acute and delayed radiation induced lymphocyte decay within 24 hrs of post exposure.

PI_NAMEs: LABAER, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: VEDAMONY, MERRILINE M

PROJECT_TERMS: absorption;Accidents;Acute;Address;Affect;Animals;Arizona;biodosimetry;Biological;Biological Markers;Biological Models;biomarker panel;biomarker selection;Blood;Bone Marrow;Categories;Cells;Classification;classification algorithm;cohort;Collaborations;Collection;cost;Coupled;Data Analyses;data curation;Data Set;design;Development;Devices;Diagnostic tests;Dose;Drops;Ensure;experience;Exposure to;Future;Gene Chips;Gene Expression Profiling;Genes;Genetic Markers;Genetic Transcription;Genomic approach;Health Personnel;Hour;Human;human model;improved;in vivo;in vivo Model;Individual;Injury;Ionizing radiation;Laboratories;Literature;Lymphocyte;Lymphocyte Count;Lymphocyte Depletion;Measures;Medical;Methods;Modeling;Mus;next generation sequencing;Normal Range;novel strategies;Nuclear Accidents;Nucleic Acid Amplification Tests;Organ;organ injury;Paper;Patients;peripheral blood;personalized diagnostics;point of care;point of care testing;Population;population based;predictive marker;Probability;Radiation;radiation absorbed dose;Radiation Accidents;Radiation Dose Unit;Radiation exposure;Radiation Injuries;Radiation Tolerance;Radiation-Induced Gene Expression;Recommendation;Resource-limited setting;Resources;response;Risk;risk prediction;RNA;Sampling;screening;specific biomarkers;Specificity;Techniques;Technology;Terrorism;Testing;Therapeutic Intervention;Time;Tissues;tool;Triage;Universities;Work;Zika Virus

PROJECT_TITLE: Rapid Low-Cost Paper-based Biodosimetry that reveals individual organ injuries


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Nutrition

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: PROJECT NARRATIVE Virtually every mammalian tissue exhibits overt 24-hour rhythms in gene expression that are critical for coordinating the daily activity of nearly every biological function and maintaining cellular homeostasis. The proposed study will determine the role of feeding rhythms and of the mTOR signaling pathway in the regulation of rhythmic gene expression in mouse liver. Our results are expected to uncover exciting findings on how rhythmic food intake regulates the activity of the mTOR pathway to set along with the molecular circadian clock a harmonized rhythmic gene expression network and prevents the development of pathological disorders.

PI_NAMEs: MENET, JEROME  (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: Arrhythmia;Binding;Biochemical;Biochemical Pathway;Biological;Biological Process;Bypass;Cardiovascular Diseases;Cells;Chronotherapy;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Complement;Complex;Data;detection of nutrient;Development;Disease;Drug usage;Eating;Elderly;Exhibits;experimental study;feeding;FRAP1 gene;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;glycogenesis;Half-Life;Hepatic;Homeostasis;Hour;Human;Impairment;in vivo;Knock-out;lipid biosynthesis;Liver;Malignant Neoplasms;Mammalian Cell;Mammals;Mediating;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;Molecular;molecular clock;mTOR inhibition;mTOR Inhibitor;mTOR Signaling Pathway;Mus;Mutation;novel;novel strategies;Pathologic;Pathway interactions;Periodicity;Peripheral;pharmacologic;Pharmacological Treatment;Phosphotransferases;Physiology;prevent;Publishing;Regulation;restoration;Role;Signal Transduction;Sirolimus;suprachiasmatic nucleus;Testing;Time;Tissues;transcription factor;Transcriptional Regulation;transcriptome;United States;virtual;Wild Type Mouse

PROJECT_TITLE: Regulation of circadian physiology by rhythmic food intake and the mTOR pathway

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: The next generation of viral vaccines and biologics alike will be designed rationally, based on a structural understanding of how protective antibodies engage the epitope of the target. The multidisciplinary group in this application will develop and implement new structure based computational models, and then validate the power of the computational design approach with laboratory experiments focused on the structural basis of broad neutralization of influenza through recognition of the a novel site of vulnerability in the interface of the hemagglutinin head domain.

PI_NAMEs: CROWE, JAMES E (contact)

PROGRAM_OFFICER_NAME: BREEN, JOSEPH J

PROJECT_TERMS: Affinity;Antibodies;antibody engineering;Antibody Repertoire;Antigen Presentation;Antigens;B-Lymphocytes;Binding;Binding Sites;Biological;Biological Products;Blood Cells;Cells;combat;Complex;Computer Models;cross reactivity;Crystallography;design;design verification;Development;Electron Microscopy;Engineering;Epitope Mapping;Epitopes;Experimental Models;Exposure to;Generations;Genes;Glycoproteins;Goals;Hand;Head;Hemagglutinin;Human;Immune;Immune response;Immunity;immunogenicity;in silico;In Vitro;in vivo;Individual;Infection;Influenza;Influenza Hemagglutinin;Influenza vaccination;influenza virus strain;influenza virus vaccine;influenzavirus;innovation;Knowledge;Laboratories;laboratory experiment;Linear Programming;Machine Learning;Mass Spectrum Analysis;Memory B-Lymphocyte;Methods;Modeling;molecular recognition;monomer;mouse model;multidisciplinary;nanoparticle;Nature;neutralizing antibody;next generation;next generation sequencing;novel;pandemic potential;particle;Polysaccharides;Population;programs;protective efficacy;Proteins;rational design;Reaction;receptor binding;Research;Research Project Grants;response;Roentgen Rays;scaffold;screening;Seasons;Sequence Analysis;Site;Standardization;structural biology;Structure;Techniques;Testing;Therapeutic antibodies;therapeutic vaccine;tool;universal influenza vaccine;Vaccine Antigen;vaccine candidate;Vaccine Design;Vaccines;Validation;Viral;Viral Vaccines;Virus;Virus Diseases;X-Ray Crystallography

PROJECT_TITLE: Structure based design of trimer interface epitope focused universal influenza vaccines


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative This proposal outlines the functions of the Computational and Statistical Analysis Core, which will operate as a part of the INIA Stress and Chronic Alcohol Interactions (INIAstress) Consortium. This U24 Core will facilitate the research mission of INIAstress by providing cutting-edge data analyses, computational models, and open source data approaches. By infusing the research components with these approaches, this will enhance synergy and rigor of the science performed across the consortium.

PI_NAMEs: LAPISH, CHRISTOPHER COURT (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Adoption;Agreement;alcohol use disorder;Alcohols;Animal Model;Animals;Archives;Artificial Intelligence;Behavior;Big Data;biophysical properties;Brain;Chronic;Communities;Complex;complex data;Computer Analysis;Computer Models;Consult;Data;data access;data acquisition;Data Aggregation;Data Analyses;data integration;data repository;Data Set;denoising;density;dimension reduction;Electrophysiology (science);Ensure;Experimental Designs;experimental study;Fiber;Fracture;Funding;Future;Goals;Human;human data;improved;in silico;innovation;Knowledge;large datasets;Lead;Link;Mathematics;Methods;Mission;Modeling;neural;Neurons;novel;open data;Outcome;patch clamp;Photometry;Play;Positioning Attribute;pre-clinical;Publications;repository;Research;Research Personnel;Resources;Risk;Risk Factors;Risk Marker;Role;Science;Secure;Series;Signal Transduction;Site;Sorting;Source;Standardization;Statistical Data Interpretation;Statistical Models;Stress;synergism;System;Techniques;Testing;Time;Time Series Analysis;translational impact;Translations;United States National Institutes of Health;web portal;web site;Work

PROJECT_TITLE: CORE 1/2: INIA Stress and Chronic Alcohol Interactions: Computational and Statistical Analysis Core (CSAC)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Consumption of ultra-processed foods is linked with obesity, type 2 diabetes, multiple forms of cancer, increased incidence of cardiovascular disease, and overall increased all-cause mortality. Uncovering the basic mechanisms of why these foods are so rewarding and overconsumed is essential to develop strategies to improve health and reduce the disease burden driven by consumption of these foods. To this end, we will combine metabolic, neural, and behavioral measures with advanced predictive modeling to uncover key factors that drive ultra-processed food reward in humans.

PI_NAMEs: DIFELICEANTONIO, ALEXANDRA GOLD (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: abuse liability;addiction;Affect;Area;Automobile Driving;behavior measurement;Behavioral;blood oxygenation level dependent response;Brain;Brain region;burden of illness;Calories;Carbohydrates;Cardiovascular Diseases;Cephalic;conditioning;Confounding Factors (Epidemiology);Consumption;Corpus striatum structure;Cues;Data;density;dietary guidelines;Disease;Dopamine;drug of abuse;drug quality;energy density;Energy Metabolism;Energy-Generating Resources;experimental study;Fiber;Food;food consumption;food environment;Food Processing;Food Supply;Formulation;Fortified Food;Future;Glucose;Glycemic Index;Goals;Health;Human;Hyperphagia;improved;Incidence;Individual;Individual Differences;Industrialization;Infusion procedures;innovation;Intake;Intervention;Learning;Link;Machine Learning;Macronutrients Nutrition;Malignant Neoplasms;Measures;Metabolic;Metabolic dysfunction;metabolic rate;Metabolism;Modeling;Modernization;mortality;Motivation;neural;neurobiological mechanism;Neurobiology;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;nutrient absorption;Nutrient availability;Obesity;Outcome;oxidation;Pharmaceutical Preparations;Phase;Physiological;Physiology;predictive modeling;Predisposition;preventable death;Process;Property;Psychological reinforcement;Recording of previous events;Reducing diet;Research;response;Rewards;Rodent;Role;Signal Transduction;Source;Speed;Surface;System;Testing;Time;Weight Gain

PROJECT_TITLE: Ultra-processed food reward: neural and metabolic factors

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE The experiments in this proposal explore ways in which microorganisms adapt to the infected host to favor their own survival. The investigators have identified microbe-specific features that mediate these adaptations, suggesting new targets for antimicrobial therapy. Additionally, these experiments will explore how understanding and intervening with the host response to infection might also contribute to the optimal treatment of infectious diseases.

PI_NAMEs: ALSPAUGH, ANDREW  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;anti-fungal agents;antimicrobial;Applications Grants;Arrestins;Basidiomycota;Biochemical;cancer therapy;capsule;Cell membrane;Cell Physiology;Cell surface;Cell Wall;Cells;Cellular Stress;Cessation of life;Collection;comparative;Complex;Cryptococcus neoformans;Data;Disease;Drug Tolerance;Environment;Eukaryotic Cell;Event;experimental study;extracellular;fitness;fungus;Future;Genetic;genetic manipulation;Genetic Screening;Genetic Techniques;Goals;Human;Immune;Immune response;Immune system;Impairment;In Vitro;in vivo;in vivo Model;Infection;infectious disease treatment;Intervention;Mediating;Microbe;microbial;Microbial Genetics;microbial host;microorganism;Modeling;Molecular;mutant;Mycoses;novel;Nutrient availability;opportunistic pathogen;optimal treatments;Organ Transplantation;Pathogenesis;pathogenic fungus;pathogenic microbe;Pathogenicity;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphorylation;Plasma Cells;Post-Translational Protein Processing;Prevention;Process;Proteins;Proteomics;Regulation;Research Personnel;response;Risk;scaffold;screening;sensor;Signal Pathway;Signal Transduction;Stress;Surface;System;Testing;trafficking;transcriptomics;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Variant;Virulence

PROJECT_TITLE: Coordinated responses to host-derived stresses in C. neoformans


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NEW HAVEN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE This project will lead to a tissue-engineered model to mimic the microvascular niche in human brain tumor. It can be used to elucidate the biological mechanism in brain tumor stem cell maintanence, tumor infiltration, and functional heterogeneity. It also has the potential utility for personalized drug testing and therapeutic stratification.

PI_NAMEs: FAN, RONG  (contact);ZHOU, JIANGBING

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;angiogenesis;Animal Model;Animals;Biocompatible Materials;Biological;Biological Assay;Biology;Biomedical Engineering;Blood Vessels;Bone Marrow;Brain;brain control;Brain Neoplasms;Cancer Biology;Cancer Center;cell behavior;Cell Culture Techniques;cell type;Cells;Cerebrovascular system;chemotherapy;Classification;Clinic;clinical application;Clinical Data;Coculture Techniques;cohort;cost;Cultured Tumor Cells;Data;Development;Disease;Disease Progression;Distant;Drug Delivery Systems;drug testing;Environment;experience;Gel;genetic signature;Genetic Transcription;Glioblastoma;Glioma;Heterogeneity;Human;improved;In Vitro;in vitro Model;in vivo Model;Individual;Infiltration;interest;Invaded;Laboratories;leukemic stem cell;Libraries;Link;Maintenance;Malignant neoplasm of brain;Malignant Neoplasms;Measures;medical schools;Microfluidics;microsystems;mid-career faculty;migration;Modeling;Molecular;Molecular Biology;Motivation;mouse model;multidisciplinary;neoplastic cell;neuropathology;neurosurgery;novel;Oncology;Pathologic;Pathology;patient derived xenograft model;patient prognosis;Patients;Perfusion;Pericytes;Perivascular Neoplasm;Pharmaceutical Preparations;Phenotype;Pilot Projects;precision drugs;precision medicine;predict clinical outcome;Primary Brain Neoplasms;Primary Neoplasm;Prognosis;Proliferating;Property;Proteomics;real time monitoring;Relapse;Reproducibility;Resistance development;Resolution;response;Sampling;self-renewal;single cell analysis;single-cell RNA sequencing;small molecule;Specimen;spheroids;stem cells;stem-like cell;Structure;success;synergism;System;targeted treatment;Technology;technology validation;Testing;therapy resistant;Tissue Engineering;Training;transcriptome;transcriptome sequencing;transcriptomic profiling;treatment stratification;tumor;Tumor Cell Migration;tumor heterogeneity;Tumor Stem Cells;Tumor Subtype;Universities

PROJECT_TITLE: Ex vivo analysis of human brain tumor cells in a microvascular niche model

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Breast Cancer;Cancer;Genetics;Neurosciences;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Breast cancer metastasis to the brain is rising in prevalence and is an increasingly lethal threat to the patients. Our research objective is to determine the mechanism by which microRNA secreted by breast cancer cells alters normal cells in the brain to promote metastasis. This understanding could help researchers develop novel predictive biomarkers and therapeutic treatments to prevent cancer cells from metastasizing to the brain.

PI_NAMEs: WANG, SHIZHEN EMILY (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Adverse effects;Antisense Oligonucleotides;Astrocytes;Back;Biological Markers;blood-based biomarker;Brain;brain cell;brain metabolism;brain tissue;Breast;Breast Cancer Cell;breast cancer diagnosis;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Treatment;cancer cell;carcinogenesis;Cell membrane;Cell secretion;cell type;Cells;circulating microRNA;Clinical;clinical biomarkers;clinical decision-making;clinical development;clinical diagnosis;Coculture Techniques;Communication;Complex;Coupling;Dependovirus;Development;Disseminated Malignant Neoplasm;Early Diagnosis;Encapsulated;Energy Metabolism;Excision;Experimental Models;extracellular;extracellular vesicles;Future;Gene Expression;Genetic;Glutamate Transporter;Glutamates;Glutamine;Glycolysis;Goals;Growth;high risk;Homing;Implant;improved;Investigational Therapies;Knowledge;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Mammary Neoplasms;Membrane Transport Proteins;Metabolic;Metabolism;metabolomics;Metastatic breast cancer;Metastatic malignant neoplasm to brain;MicroRNAs;Modeling;Modification;Molecular;mortality;mouse model;mRNA Transcript Degradation;mRNA Translation;Neoplasm Metastasis;Neurons;Neurotransmitters;new therapeutic target;Normal Cell;novel;novel strategies;novel therapeutic intervention;Nutrient;Pathway interactions;Patients;personalized therapeutic;predictive marker;Prevalence;prevent;Prevention;Preventive;Process;programs;Radiation therapy;Regimen;Research;Research Personnel;Resected;Role;Route;Sampling;Serum;Signal Transduction;Slice;Specimen;stable isotope;standard care;Synaptic Cleft;Testing;Therapeutic;therapeutic target;tumor;tumor growth;tumor microenvironment;Xenograft procedure

PROJECT_TITLE: Role of breast cancer secreted miRNA in brain metastasis

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Substance Misuse

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: NARRATIVE There is a complex interaction between stressful life experiences, alcohol drinking, and the risk for developing an alcohol use disorder (AUD). The work conducted in this Core will combine the INIAstress model of stress- induced escalation of alcohol drinking in dependent mice with cutting-edge whole-brain imaging technology, advanced network analysis of activated cells, and pharmacological targeting of key systems important for stress- alcohol interactions. The overall goal is to identify novel brain regions and networks and evaluate how these networks are altered by pharmacological manipulation of critical target systems.

PI_NAMEs: LOPEZ, MARCELO F. (contact);MULHOLLAND, PATRICK J.

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Acute;Alcohol consumption;alcohol exposure;alcohol relapse;alcohol use disorder;Alcohols;alpha-adrenergic receptor;anxiety-like behavior;Automobile Driving;Behavior;Behavioral;behavioral phenotyping;Biological;Brain;brain circuitry;Brain imaging;BRAIN initiative;Brain Mapping;Brain region;Cells;Chromosome Mapping;Chronic;Chronic stress;Cognitive deficits;Communities;Complex;Computer Analysis;Coping Skills;Data;Development;Doxazosin;drinking;Ethanol;Ethanol dependence;experience;FOS gene;Funding;Gene Expression;Generations;genetic signature;Goals;Heavy Drinking;hypothalamic-pituitary-adrenal axis;Image;Imaging technology;Immediate-Early Genes;Impaired cognition;Individual;Inhalation;innovation;insight;kappa opioid receptors;Light;Maintenance;Maps;Modeling;mouse model;Mus;Nature;negative affect;neural;neural circuit;neuroadaptation;Neurobiology;Neurosciences;noradrenergic;novel;open data;Pathway Analysis;Pattern;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacology;Pharmacology Study;Phenotype;Play;preclinical study;Recording of previous events;Relapse;Reproducibility;Research Personnel;Resources;response;Risk;Risk Factors;Role;Statistical Data Interpretation;Statistical Models;Stress;stress reduction;Stressful Event;stressor;Swimming;System;Technology;Testing;tool;vapor;Work

PROJECT_TITLE: CORE 2/2: INIA Stress and Chronic Alcohol Interactions: CIE-Stress Mouse Brain Activity Mapping Core (BAMC)


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Palliative Care;Physical Activity;Pregnancy;Prevention;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: PROJECT NARRATIVE/ RELEVANCE TO PUBLIC HEALTH Nearly 20% of women in the U.S. (1 million women per year) experience clinically significant depressive symptoms during the perinatal period (pregnancy and postpartum), and social connectedness may be a modifiable factor involved in symptom persistence. A promising self-management approach called Mindful Moms has been developed and tested in our team’s pilot studies; we propose to build upon this work by evaluating Mindful Moms through a randomized controlled trial with marginalized women (minority, low socioeconomic status) who often suffer “in silence” due to various barriers in care. The successful completion of this study will provide important insights into social connectedness as a mechanism to decrease depressive symptoms in a largely understudied population.

PI_NAMEs: BODNAR-DEREN, SUSAN M;KINSER, PATRICIA ANNE (contact)

PROJECT_TERMS: active control;active control group;Address;Adult;anti-depressive agents;Anxiety;arm;Attention;Behavior Therapy;biobehavior;Capital;Caring;Child;Chronic Disease;Clinical;clinically significant;Communities;Control Groups;cost;Data;depressive symptoms;DNA Methylation;Documentation;Educational workshop;Epigenetic Process;experience;Family;Fetal Growth Retardation;Funding;genome-wide analysis;Goals;Health behavior;Individual;innovation;insight;Intervention;Intervention Studies;life span;Low income;low socioeconomic status;Manuals;marginalization;marginalized population;Maternal and Child Health;Maternal Health;Measures;member;Mental Depression;methylation pattern;mindfulness;Minority;minority communities;modifiable risk;Molecular;National Institute of Child Health and Human Development;Nurses;Outcome;Pathway Analysis;Pathway interactions;Pattern;perceived stress;perinatal depressive symptom;perinatal period;peripartum depression;Physical activity;Pilot Projects;Play;Population;Positioning Attribute;Postpartum Depression;Postpartum Period;Pregnancy;Pregnant Women;prenatal;prenatal health;primary outcome;Protocols documentation;Psychologist;Psychotherapy;Public Health;Randomized;Randomized, Controlled Trials;Research;Research Design;Research Priority;response;Risk;Risk Factors;Role;Scientist;secondary outcome;Self Management;Severities;side effect;social;Social isolation;Social Network;social stigma;Societies;sociologist;standard of care;Stress;Suicide;symptom management;symptom self management;Symptoms;Testing;theories;Time;Underserved Population;United States;United States National Institutes of Health;Visit;Woman;Work;Yoga

PROJECT_TITLE: Biobehavioral perspectives on social connectedness and the âMindful Momsâ intervention for marginalized pregnant women with depression


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Substance Misuse

PHR: PROJECT NARRATIVE Relapse to alcohol use in dependent individuals is exacerbated by stress and the experiments outlined in this proposal will help inform our understanding of the neurobiological mechanisms that underly the complex relationship between alcohol use disorder (AUD) and exposure to stress. Ultimately, the data collected from these studies will provide valuable information about mechanisms that contribute to uncontrolled alcohol use, cognitive dysfunction and anxiety-like behaviors characteristic of AUD, and will help to identify new pharmacotherapeutic targets for the treatment of AUD, especially in the context of chronic stress.

PI_NAMEs: RINKER, JENNIFER ANNE (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: affective disturbance;alcohol abstinence;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol seeking behavior;alcohol use disorder;Alcohols;Anterior;Anxiety;anxiety-like behavior;Automobile Driving;Behavior;Behavioral;biological adaptation to stress;Brain;Calcium;Cells;Characteristics;Choice Behavior;Chronic;Chronic stress;Cognition;Cognitive;cognitive control;Cognitive deficits;cognitive performance;Collaborations;comorbidity;Complex;Computer Analysis;Conflict (Psychology);Corticotropin-Releasing Hormone;Costs and Benefits;Coupled;CRH gene;Data;Data Set;Decision Making;density;Dependence;design;Desire for food;differential expression;Disease;effective therapy;Electrophysiology (science);Ethanol;Ethology;Excision;experimental study;Exposure to;Fiber;flexibility;Fluorescence-Activated Cell Sorting;functional plasticity;Genes;Genetic;Glutamates;Heavy Drinking;human model;Hypothalamic structure;Impaired cognition;Individual;Intervention;Investigation;Knock-out;Machine Learning;maladaptive behavior;Medial;Mediating;Mental Depression;Modeling;Molecular;Mood Disorders;motivated behavior;Motivation;Mus;negative affect;neural;neural circuit;neurobiological mechanism;Neurons;neuropsychiatry;Nucleus Accumbens;Output;Pathway interactions;Phenotype;Photometry;Prefrontal Cortex;prevent;recruit;Regulation;Relapse;response;Rewards;Rodent Model;Role;Silicon;Site;Slice;Statistical Data Interpretation;Stress;Structure of paraventricular nucleus of thalamus;Study models;superresolution imaging;Swimming;Synapses;Synaptic plasticity;Task Performances;Techniques;Testing;Thalamic structure;therapeutic target;transcriptome sequencing;Ventral Striatum;Work

PROJECT_TITLE: 4/8: INIA Stress and Chronic Alcohol Interactions: Role of corticotropin-releasing factor in cortico- and thalamo-striatal pathways in regulating alcohol-stress interactions


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Concurrent alcohol drinking and stress is a risk factor for excessive drinking and deficits in cognitive function in favor of performing habitual actions. The proposed research will use sophisticated in vivo neuroimaging methods to measure dynamic changes in brain circuitry and brain metabolism across the history of exposure to alcohol, stress, or in combination of the two. This will open a new pathway for diagnosing the severity of brain impairments and developing treatments for chronic ethanol.

PI_NAMEs: CUZON CARLSON, VERGINIA CARMELLA;KROENKE, CHRISTOPHER D (contact)

PROJECT_TERMS: Acetates;Acids;Affect;Alcohol consumption;alcohol effect;alcohol exposure;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;allostasis;Aminobutyric Acids;Anxiety;Behavior;Biochemical;blood glucose regulation;Brain;brain circuitry;brain dysfunction;brain metabolism;Brain region;Cells;Cerebrum;Chronic;chronic alcohol ingestion;Chronic stress;Citric Acid Cycle;cognitive function;Corpus striatum structure;Coupling;Data;Development;Diagnosis;drinking;drinking behavior;Electrophysiology (science);Ethanol;Experimental Designs;experimental study;flexibility;frontal lobe;Future;Genetic;genetic manipulation;Glucose;glucose metabolism;Glutamates;Heavy Drinking;Homeostasis;Human;human subject;Impaired cognition;improved;in vivo;Interneurons;Light;Macaca mulatta;Magnetic Resonance Spectroscopy;Measurement;Measures;Metabolic;metabolic abnormality assessment;Metabolism;metabolomics;Methods;Monitor;Mouse Strains;Mus;neural;neural circuit;neuroadaptation;neurochemistry;neuroimaging;neuromechanism;Neurons;neuroregulation;Neurotransmitters;nonhuman primate;Parvalbumins;Pathway interactions;Pattern;Polydipsia;Population;preservation;Primates;Procedures;putamen;Recombinants;Recording of previous events;Research;Research Personnel;restoration;Risk Factors;Role;Schedule;Severities;Slice;Stress;Swimming;Techniques;Time;Validation;Work

PROJECT_TITLE: Project 7/8: INIA Stress and Chronic Alcohol Interactions: Cross-species studies of metabolic allostasis and altered striatal circuitry


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Osteoporosis;Physical Activity;Women's Health Research

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: PROJECT NARRATIVE Exercise and physical loading support bone health, and better understanding the cellular mechanisms involved will help to treat an aging population facing degenerative bone diseases. This project studies the signaling pathways by which irisin, a signaling factor released from muscle during exercise, affects key cells within bone to guide adaptation of the tissue. By delineating these mechanisms, our work will contribute to the understanding of skeletal adaption and inform future efforts at developing therapeutics to protect bone health.

PI_NAMEs: ESTELL, EBEN GRANT (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Address;Adipose tissue;Affect;aging population;Alleles;Anabolism;Back;Binding Proteins;bone;Bone Density;Bone Diseases;bone health;bone loss;Bone remodeling;Bone Resorption;Brain;Calcium;Calcium Signaling;Catabolism;Cell Line;Cell membrane;Cell model;Cell Nucleus;Cells;chemical release;Chemicals;Coculture Techniques;conditional knockout;cortical bone;Coupling;Cues;Degenerative Disorder;deprivation;Dose;Equilibrium;Estrogens;Event;Exercise;experimental study;Fibronectins;functional outcomes;Future;Genetic;genetic approach;Genetic Transcription;Homeostasis;Hormones;Image;In Vitro;in vivo;in vivo Model;Infusion procedures;insight;Integrins;Investigation;Knockout Mice;Liquid substance;LoxP-flanked allele;Maintenance;mechanical signal;mechanical stimulus;Mediating;Mitochondria;Modeling;Mus;Muscle;novel;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteocytes;Osteogenesis;Ovariectomy;Pathway interactions;Peptide Signal Sequences;Physiological;pleiotropism;prevent;programs;Protein Secretion;Proteins;Proteomics;receptor;Regulation;release factor;Research;Respiration;response;Role;Serum;Signal Pathway;Signal Transduction;skeletal;Skeletal Development;Skeletal Muscle;Techniques;Testing;Therapeutic;therapeutic development;Thick;Tissue Model;Tissues;TRANCE protein;transcriptome sequencing;Wild Type Mouse;Work

PROJECT_TITLE: The Role of Irisin in Initiating Resorption During the Skeletal Response to Exercise


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Caregiving Research;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Services;Liver Disease;Mental Health;Organ Transplantation;Prevention;Transplantation

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Liver transplantation, the only lifesaving treatment for end-stage liver disease, is increasingly performed for older adults with multiple comorbidities and physical and cognitive impairments. Navigating post-transplant medical care is complex and requires formidable cognitive and self-management skills. This project will study how cognitive impairment and self-management skills among liver transplant recipients and their caregivers influence health status, health behaviors, and outcomes to inform future health-system interventions to reduce complexity and optimize long-term health after liver transplantation.

PI_NAMEs: SERPER, MARINA  (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Accounting;Active Learning;Affect;Age;Alcohol consumption;Alcoholic Liver Diseases;baby boomer;Behavior;cardiometabolism;Cardiovascular system;care coordination;care delivery;Caregiver support;Caregivers;Caring;Chronic;Cirrhosis;Clinical;Cognition;Cognitive;cognitive ability;cognitive function;cognitive load;cognitive performance;cognitive recovery;cohort;Cohort Studies;Communities;comorbidity;Complex;cost;Dose;end stage liver disease;executive function;frailty;functional independence;functional status;Future;Health;Health behavior;Health behavior and outcomes;Health Care Costs;health care service;health literacy;health management;Health Status;Health system;Healthcare;Heart Transplantation;Hepatic Encephalopathy;High Prevalence;high risk;human old age (65+);Immunosuppression;Impaired cognition;Impairment;improved;Infection;insight;Intervention;Investigation;Kidney Transplantation;Life;Life Style;Liquid substance;liver transplantation;longitudinal care;Malnutrition;Mediating;Mediator;Medical;Medical Care Costs;Memory;Metabolic;Monitor;mortality;multiple chronic conditions;Nature;Neurologic;North America;novel;older adult;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacists;Physical activity;Physical Function;physical impairment;physical inactivity;poor sleep;Population;post-transplant;postoperative delirium;Prevalence;prevent;Problem Solving;processing speed;Recommendation;Regimen;Reporting;Resources;response;Risk Factors;Sampling;sarcopenia;Self Assessment;Self Care;Self Management;side effect;skills;Sleep;sleep quality;Substance abuse problem;Time;transplant centers;Transplant Recipients;Transplantation;treatment adherence;United States National Institutes of Health;Waiting Lists

PROJECT_TITLE: Cognitive Function, Self-Management, and Health Outcomes among Liver Transplant Recipients: the LivCog Cohort

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: PROJECT NARRATIVE This proposal is focused on elucidating the regulation and structure/function relationships of a single enzyme, OGT, involved in post-translational modification of thousands of protein substrates. This work builds on our recent discovery that mutations in the OGT gene are causal for X-linked intellectual disability. The proposed efforts will uncover a mechanistic understanding of the impact of the disease variants and lay the groundwork for being able to ameliorate consequences of the disability.

PI_NAMEs: WELLS, LANCE  (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Affect;Amino Acid Substitution;Automobile Driving;Binding;Biochemical;Biology;Catalysis;Catalytic Domain;causal variant;Cells;Characteristics;Chromatin;Clinical;clinical phenotype;Complex;Data;Defect;disability;Disability phenotype;Disease;embryonic stem cell;Engineering;Enzymes;Epigenetic Process;Evolution;Exhibits;experimental study;Gene Duplication;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Screening;genome wide screen;glucose transport;human embryonic stem cell;Hydrolase;In Vitro;Intellectual functioning disability;Isotopes;Knockout Mice;Lead;Ligation;Link;male;Mammals;Mass Spectrum Analysis;Mediating;Microelectrodes;Missense Mutation;Modeling;Modification;Molecular;molecular modeling;Mutation;nerve stem cell;neural;novel;Nuclear;Nutrient;O-GlcNAc transferase;Outcome;overexpression;Pathway interactions;Patients;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Play;Polysaccharides;Post-Translational Protein Processing;protein protein interaction;Proteins;Publishing;Regulation;Research;Role;sample collection;Sampling;Scaffolding Protein;screening;sensor;Site;stem cell differentiation;stem cells;Structure;Substrate Specificity;sugar nucleotide;Synapses;synaptic function;synaptogenesis;Synaptosomes;tandem mass spectrometry;Testing;tool;transcriptome;Transferase;Variant;Work;X-linked intellectual disability

PROJECT_TITLE: The Role of the O-GlcNAc Modification in X-linked Intellectual Disability

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: Nashville

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Project Narrative Alcohol abuse is a major public health concern, resulting in close to 100,000 deaths per year in the United States alone. Cognitive deficits and maladaptive responses to stress are known to be cooccurring factors associated with alcohol use disorder and determining how these factors contribute to susceptibility and resilience would help to improve prevention and treatment strategies. This proposal focuses on precisely defining how the function of specific circuits in prefrontal cortex mediate interactions between cognition, stress, and the development of harmful alcohol drinking patterns.

PI_NAMEs: SICILIANO, CODY  (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: addiction;Alcohol abuse;alcohol consequences;Alcohol consumption;alcohol craving;alcohol exposure;alcohol seeking behavior;alcohol use disorder;alcohol use initiation;Alcohols;Automobile Driving;Behavior;Behavioral;Behavioral Assay;Brain;brain control;Brain region;Calcium;cell cortex;cell type;Cells;Cessation of life;Chronic;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive performance;Collaborations;combinatorial;comorbidity;Complex;Data Set;Development;disease prognosis;diverse data;drinking;Dyes;experimental study;Exposure to;Female;flexibility;Goals;Grant;Head;Heavy Drinking;histological image;Human;Image;imaging approach;Immunohistochemistry;Impaired cognition;improved;in vivo;Individual Differences;insight;Intoxication;Label;longitudinal design;Macaca mulatta;male;Maps;Medial;Mediating;Mediator;Methodology;Microscope;Modeling;Monkeys;mouse model;Mus;neural;neurobehavioral;Neurobiology;neuroimaging;Neuronal Plasticity;Neurons;nonhuman primate;novel;Occupations;optogenetics;Pattern;Phase;Phenotype;photoactivation;Play;Population;Predisposition;Prefrontal Cortex;Prevention strategy;Probability;Procedures;Prognosis;Public Health;Punishment;recruit;resilience;Resistance;Resolution;response;Reversal Learning;Risk Factors;Rodent;Role;Sampling;Self Administration;Slice;Stress;stress reactivity;stressor;Swimming;synergism;System;Technology;Testing;Tissues;Transgenes;Transgenic Organisms;treatment strategy;United States;Ventral Tegmental Area

PROJECT_TITLE: 8/8: INIA Stress and Chronic Alcohol Interactions: Cross-species plasticity signatures of alcohol and stress


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE A high density of tobacco retailers in communities is strongly linked to tobacco use behaviors and contributes to tobacco-related health disparities. This project will evaluate the impact and equity of a novel, environmental- level policy intervention to reduce tobacco retailer density in pioneering US cities. Study results will provide timely and essential guidance to inform equitable policy formation and improve implementation in order to maximize impact and reduce persistent health disparities.

PI_NAMEs: GIOVENCO, DANIEL PHILIP (contact)

PROGRAM_OFFICER_NAME: MAYER, MARGARET ELIZABETH

PROJECT_TERMS: Adult;Attention;Behavior;behavior change;Behavioral;Behavioral Mechanisms;career;Case Study;Characteristics;Charge;cigarette smoking;Cities;Communities;community engaged research;Community Health;comparative;Contracts;Data;demographics;density;Disparity;Economically Deprived Population;Empirical Research;Ensure;Environment;Environmental Impact;Equity;Ethnic Origin;Evaluation Research;Excision;falls;frontier;Goals;Grant;Health;health disparity;health equity;health equity promotion;Health Surveys;improved;Income;Individual;inequitable distribution;interest;Intervention;intervention effect;Interview;Licensing;Link;Low income;marginalization;marginalized population;Marketing;Measures;Methods;Modeling;Municipalities;Neighborhoods;New York City;novel;novel strategies;Pattern;Perception;Pharmacy facility;Philadelphia;Policies;Policy Developments;Population;population survey;preventable death;Public Health;Public Policy;public policy on tobacco;Race;Research;Respondent;Sales;Sampling;San Francisco;Scientist;Site;Smoking;Smoking Behavior;social disparities;sociodemographics;socioeconomic disparity;spatial epidemiology;Structure;Subgroup;substance use;Testing;Time;Time trend;Tobacco;tobacco control;tobacco products;Tobacco use;trend;United States National Institutes of Health;Variant

PROJECT_TITLE: Assessing the impact, equity, and mechanisms of a novel policy intervention to reduce tobacco retailer density in communities

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Microbiome;Pain Research;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Sickle cell disease (SCD) disproportionally impacts underrepresented minority populations and remains grossly understudied . The proposed research will help us understand how variations in environmental exposures and immune responses predicated upon health disparities predispose children with SCD to poor clinical outcomes. The proposal is relevant to public health and the NIH’s mission as the findings will help improve the prediction, prevention, and treatment of acute complications in children with SCD with strategies that move beyond the current paradigm of supportive and/or reactive care.

PI_NAMEs: CREARY, SUSAN ;HOOD, DARRYL BRICE;KOPP, BENJAMIN T (contact);MEJIAS, ASUNCION ;RAMILO, OCTAVIO

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acute;acute chest syndrome;Address;Age;Air;Anti-Inflammatory Agents;Big Data Methods;Biological;biological adaptation to stress;Blood;built environment;Caring;Cell Culture Techniques;Characteristics;Child;Child Health;Chronic;Chronic Disease;Clinical;Clinical Data;cohort;Cohort Analysis;Communities;Data;Data Set;Databases;design;Development;Disease Outcome;disorder control;Disparate;effective intervention;Environment;Environmental Exposure;Environmental Risk Factor;Erythrocytes;Event;Exogenous Factors;experience;Exposure to;Foundations;Frequencies;Future;Gene Expression Profile;Genetic;Genetic Transcription;Goals;gut microbiome;Health;health disparity;health equity;health outcome disparity;Hematological Disease;Hematology;high risk;Hormonal;Human;Immune;immune function;Immune response;Immune system;Immunologics;Immunology;improved;Individual;Inflammation;Inflammatory;innovation;Knowledge;Lead;Link;Liquid substance;Longitudinal cohort;Lung;Microbe;Microbiology;Minority Groups;Mission;Modeling;Morbidity - disease rate;mortality;Nasal Epithelium;novel;novel strategies;Outcome;Outcome Study;Pain;Participant;Pathway interactions;Phenotype;Policies;Population;Predictive Factor;Prevention;preventive intervention;prospective;Proteomics;Public Health;Pulmonology;Race;Recurrence;Research;respiratory microbiome;Risk;Sampling;Shapes;Sickle Cell;Sickle Cell Anemia;Signal Transduction;social;social health determinants;Societal Factors;sociodemographic factors;Soil;Specialist;stressor;Technology;Testing;Therapeutic Intervention;Time;transcriptomics;Underrepresented Minority;United States National Institutes of Health;Variant;vaso-occlusive pain;Water;Work

PROJECT_TITLE: SMILE: Sickle Cell Disease Microbiologic and Immunologic Links to Health Equity

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Coronaviruses;Social Determinants of Health

ORG_CITY: BOWLING GREEN

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BOWLING GREEN STATE UNIVERSITY

PHR: Narrative Healthy People 2030 stresses the importance of the social determinants of health, including the family and the COVID-19 Pandemic has brought emphasis to the effects of structural determinants of health. Our goals fit squarely within the vision of the NICHD and specifically the Population Dynamics Branch (PDB) to help understand changes—including new challenges—shaping families and provide data useful for timely assessments of community health. These data will provide researchers and practitioners monthly point-in-time estimates of social and community context—an effective tool for understanding the changing landscape of marriage and families in the United States and its effect on health.

PI_NAMEs: WESTRICK-PAYNE, KRISTA KAY (contact)

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Affect;American;archive data;Archives;Attention;Awareness;Behavior;Censuses;Cessation of life;Classification;Collaborations;Communities;Community Health;Community Surveys;County;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Analyses;Data Collection;Data Set;data sharing;Deterioration;Divorce;Documentation;Economics;Etiology;Event;experience;Family;Friends;Funding;geographic difference;Goals;Health;Hospitalization;Household and Family;Individual;innovation;Investigation;Knowledge;Legal;Letters;Life;Link;Location;Marital Status;Marriage;Marriage and Family;Measures;Michigan;Mission;multidisciplinary;National Institute of Child Health and Human Development;NIH Program Announcements;Nuptiality;pandemic disease;pandemic impact;pandemic response;Pattern;Personal Satisfaction;Persons;Physiologic pulse;Policies;Policy Maker;Politics;Population;Population Dynamics;Population Sciences;population survey;Positioning Attribute;programs;Provider;Public Health;Publishing;Recording of previous events;Reporting;Research;Research Personnel;Resources;response;secondary analysis;Shapes;social;Social Behavior;Social Change;social health determinants;Source;Stress;structural determinants;structural health determinants;Surveys;System;Time;tool;United States;United States National Center for Health Statistics;United States National Institutes of Health;Universities;Vaccination;Variant;Vision;Vital Statistics;web site

PROJECT_TITLE: Archiving Nuptiality Pandemic Data

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]