PHR: NARRATIVE (OVERALL) The University of Michigan Rogel Cancer Center (Rogel) is committed to reducing cancer burden and improving cancer outcomes through research, innovation, transdisciplinary collaboration, education, and outreach. The Rogel vision is to be a leader in prevention, early diagnosis, optimal treatment and care for all at risk of or affected by cancer.

PI_NAMEs: FEARON, ERIC R. (contact)

PROJECT_TERMS: Abbreviations;Advanced Malignant Neoplasm;Advisory Committees;Affect;Animal Model;anti-cancer research;Appointment;Basic Science;Biological Sciences;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;cancer education;cancer genetics;career;career development;Caring;Catchment Area;Cells;cellular imaging;Clinical;Clinical Research;Clinical Trials;Clinical Trials Support Unit;Collaborations;college;Communities;community advisory board;community center;community engagement;Community Outreach;Comprehensive Cancer Center;Data Science;Development;Developmental Therapeutics Program;Direct Costs;Doctor of Philosophy;Drug Kinetics;Drug Screening;Early Diagnosis;Education;Engineering;Epigenetic Process;epigenomics;equity, diversity, and inclusion;Faculty;Female;Financial Support;Flow Cytometry;Fostering;Funding;Gifts;Glossary;Grant;Growth;health communication;health equity;Health Policy;Hematopoiesis;Immunologic Monitoring;Immunology;improved;Infrastructure;innovation;Institution;inter-institutional;interdisciplinary collaboration;Intervention;Investments;irradiation;Journals;Justice;Leadership;liquid biopsy;Malignant Neoplasms;Manuscripts;medical schools;Medicine;member;Michigan;Mission;molecular imaging;molecular pathology;Names;National Cancer Institute;next generation;optimal treatments;Outcome;outreach;Patient Care;Patients;Population Sciences;pre-clinical;Prevention;Prevention program;programs;Proteomics;Public Health Schools;Publications;Publishing;Quality of life;Recording of previous events;recruit;Research;Resource Sharing;Resources;Risk;Role;Schools;Signal Transduction;Strategic Planning;Structure;Survivors;Tissue imaging;Tissues;Training;Training and Education;Transgenic Animals;Translational Research;translational research program;Translations;tumor microenvironment;United States National Institutes of Health;Universities;University of Michigan Comprehensive Cancer Center;Vision;Work

PROJECT_TITLE: University of Michigan Rogel Cancer Center Support Grant 2023-2028

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Microbiome;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: AUGUSTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Retinopathy of prematurity (ROP) is the leading cause of blindness in children. There are limited therapeutic options for this severe ocular pathology. Our overall goal is to identify new and more effective therapies for ROP. In particular, we will explore and characterize the potential therapeutic effects of a short-chain fatty acid, butyrate in experimental models of ROP.

PI_NAMEs: JADEJA, RAVIRAJSINH  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Ablation;Affect;Angiogenesis Inhibitors;Angiogenic Factor;Anti-Inflammatory Agents;Area;Birth;Blindness;Blood Vessels;Butyrates;cell type;Cells;Child;cytokine;Data;Development;Diagnosis;disease model;dysbiosis;effective therapy;efficacy evaluation;efficacy validation;Endothelial Cells;Endothelium;Environment;Event;Experimental Models;Feces;Fermentation;G-Protein-Coupled Receptors;Goals;Growth;gut bacteria;gut microbes;HDAC1 gene;HIF1A gene;Hyperglycemia;Immunity;improved;In Vitro;Infant;Inflammation;Inflammatory;intravitreal injection;Investigation;Ischemia;Knock-out;Knowledge;Link;Mediating;microbiome;Microglia;Modeling;Molecular;Monitor;mouse model;Mus;neovascularization;novel;novel therapeutic intervention;novel therapeutics;Ocular Pathology;Operative Surgical Procedures;Oral;Oxygen;Pathogenicity;Pathologic;Pathologic Neovascularization;Pathology;Phase;Phenotype;Physiology;Predisposition;premature;Premature Birth;Premature Infant;prevent;Process;Production;Recovery;Recurrence;Retina;Retinal Detachment;Retinal Diseases;Retinal Neovascularization;Retinopathy of Prematurity;Role;Serum;side effect;Signal Transduction;Supplementation;targeted treatment;Therapeutic;Therapeutic Effect;Tissues;Treatment Efficacy;Uterus;Variant;Vascular Endothelial Growth Factors;VEGFA gene;Visual Fields;Volatile Fatty Acids

PROJECT_TITLE: Short-chain fatty acid signaling in retinopathy of prematurity

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;HIV/AIDS;Infectious Diseases;Neurosciences

ORG_CITY: OMAHA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative The existence of latent infectious virus in brain compartments during long-term suppressive ART treatment not only elicits chronic neuroinflammation and leads to HIV-1 associated neurocognitive disorders, but also one of the major factors contributing to HIV-associated early aging in people living with HIV. The proposed multimodal approach to look at functional neuro-immune interaction at molecular level in presence of new-age combinatorial ART treatment in an animal model with functional human immune system lasting more than one year (humanized mice) will identify to what extent latent reservoirs established in the CNS disrupts molecular neuronal function during progressive aging. We will also look at how cART-mediated long-term viral suppression affects the cellular crosstalk and the brain homeostasis during progressive aging, which will provide clue to the CNS specific therapeutic targeting in patients.

PI_NAMEs: DASH, PRASANTA KUMAR (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Achievement;Address;Adherence;Affect;Aftercare;Age;age acceleration;age effect;aged;Aging;aging biomarker;aging population;aging related;Animal Model;Animals;antiretroviral therapy;Anxiety;Astrocytes;Axon;Behavior;behavior measurement;behavior test;Behavioral;behavioral study;biomarker identification;Blood - brain barrier anatomy;Brain;brain cell;Brain region;Cardiovascular Diseases;cell type;Cells;Central Nervous System;Central Nervous System Infections;Cerebral hemisphere;Chemicals;Chronic;cohort;combinatorial;Combined Modality Therapy;comorbidity;Data;Diabetes Mellitus;differential expression;Diffusion Magnetic Resonance Imaging;Disease;DNA;Down-Regulation;Ensure;Fiber;Fingerprint;frailty;Functional disorder;Future;Genes;Half-Life;Hematopoietic stem cells;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;Homeostasis;Human;humanized mouse;Immune;immune reconstitution;Immune system;immunosenescence;improved;Individual;Infection;Inflammation;Injury;Intake;Life;life span;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Medical;Memory;Metabolic;Microglia;Molecular;Monitor;Motor Activity;mouse model;multimodality;Mus;Neurocognitive;Neuroimmune;neuroinflammation;Neurologic;Neurons;neurotransmission;novel;novel marker;Oligodendroglia;Outcome;Pathway interactions;Patients;Penetrance;Persons;Pharmaceutical Preparations;Population;postsynaptic neurons;Premature aging syndrome;presynaptic neurons;reconstitution;Recovery;Regimen;Reporting;Research Personnel;Risk Factors;RNA;Sampling;senescence;Signal Pathway;Signal Transduction;Testing;therapeutic target;Time;Tissues;transcriptomics;United States;Up-Regulation;Validation;Viral;Virus;Virus Latency;Virus Replication

PROJECT_TITLE: Exploring the Molecular, Neuro-immune and Behavioral changes during HIV-associated progressive aging using a long-term humanized mice model

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Immunotherapy;Liver Disease;Nutrition

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Chronic liver disease arises as a result of chronic inflammation in the liver due to a variety of environmental insults including viral infection, alcohol consumption, and diet-induced obesity. Previous studies have demonstrated a significant recruitment of T lymphocytes to the liver during the progression of chronic liver disease, but the cause and consequence of this T cell recruitment to the liver is unknown. This project will directly address why T cells expand in the liver during the progression of NASH and if T cells promote or suppress the progression of NASH.

PI_NAMEs: BURCHILL, MATTHEW A (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;Address;Adipose tissue;Affect;Alcohol consumption;Animal Disease Models;Animal Model;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Autoimmune;Award;Bioinformatics;burden of illness;CD3 Antigens;CD8-Positive T-Lymphocytes;CD80 gene;CD86 gene;CD8B1 gene;Cell Physiology;cell type;Cells;Cessation of life;Chronic;chronic liver disease;Cicatrix;Cirrhosis;Clonal Expansion;collagenase;Collection;Complement;conflict resolution;Cytoprotection;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;Deoxyribonuclease I;Development;Diamond;Diet;diet-induced obesity;Digestion;Disease;disease model;Disease Progression;Dissection;draining lymph node;effective therapy;Ego;Emu species;Epidemic;Event;feeding;Fibrosis;Flow Cytometry;Funding;Goals;Gur;Hepatic;Hepatic Stellate Cell;Hepatology;Human;Immune;Immunity;Immunologics;immunoregulation;Immunotherapy;Incidence;Individual;Induction of Apoptosis;Inflammation;Injury;Innate Immune System;Investigation;ITGAM gene;ITGAX gene;Life Style Modification;Link;Literature;Liver;Liver diseases;Liver Fibrosis;liver injury;liver transplantation;Location;Lymphatic Endothelial Cells;man;Mechanics;Metabolic dysfunction;MHC Class I Genes;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Myeloid Cells;Nature;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Obesity;Organ Transplantation;Pathogenesis;Pathology;Patients;Peptides;Persons;phenotypic biomarker;Population;prevent;Prevention;Process;programmed cell death ligand 1;programs;Proliferating;PTPRC gene;Publications;Publishing;PubMed;recruit;Reporting;Research;Resolution;Role;safran;Science;single cell mRNA sequencing;Societies;Steatohepatitis;T cell infiltration;T cell response;T-Cell Activation;T-cell receptor repertoire;T-Lymphocyte;Testing;Therapeutic Intervention;Time;tissue resident memory T cell;TNFRSF5 gene;tool;tumor;United States;Virus Diseases;Washington;XCR1 gene

PROJECT_TITLE: Defining the role of antigen-specific T cell responses in NASH

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Hepatitis - C;Infectious Diseases;Liver Disease

ORG_CITY: CHICAGO

ORG_NAME: ARETE BIOSCIENCES

ORG_STATE: IL

PI_NAMEs: JANGAM, SUJIT  (contact)

PROJECT_TERMS: Blood capillaries;Chronic;Cirrhosis;co-infection;Contracts;detection test;Development;Diagnostic;Disease Progression;global health;Health Services Accessibility;Hepatitis B;Hepatitis B Surface Antigens;Hepatitis B Virus;Hepatitis C virus;HIV;HIV diagnosis;HIV/HCV;Home;Infection;Molecular;Morbidity - disease rate;mortality;Nucleic Acid Amplification Tests;Pathogenesis;Patients;Population;response;Risk;screening;Services;social;Testing;transmission process;Viral hepatitis;Viral Load result

PROJECT_TITLE: Development of an Ultrasensitive, Rapid and Easy-to-Use At-Home Molecular Test for HCV, HBV AND HIV


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;HIV/AIDS;Infectious Diseases;Neurosciences;Pediatric;Pediatric - AIDS;Pediatric Cancer;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: Project Narrative PHACS 2020 is a Program Project P01 grant, consisting of the following four support Cores: Scientific Administrative Core (SAC), Data Resources Core (DRC), Health Education and Community Core (HECC), and the Epidemiological and Statistical Methods Core (ESC) to provide scientific, site and cohort infrastructure, data management and analysis, health education and community input, as well as epidemiological and statistical support to four Research Projects: 1) Surveillance Monitoring for ART Toxicities (SMARTT); 2) The Adolescent Master Protocol (AMP) Up Series (the AMP Up Series); 3) Natural History of Cervical Intraepithelial Neoplasia (CIN) and Human Papillomavirus (HPV) in HPV Vaccinated Youth with Perinatal HIV (PHIV) (HPV); and 4; the TERBO BRAIN Study: Trajectories of Emotional Regulation and Behavior Outcomes and related Brain Regions And Intrinsic Networks (TERBO BRAIN). This multidisciplinary, interactive and synergistic P01 will address the most critical scientific questions for children, youth and young adults living with or exposed to perinatal HIV.

PI_NAMEs: CHADWICK, ELLEN GOULD;HERNANDEZ-DIAZ, SONIA ;JAO, JENNIFER ;WILLIAMS, PAIGE L (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: 13 year old;Address;Adolescent;Adolescent and Young Adult;Adult;adverse birth outcomes;Age;Aging;Anti-Retroviral Agents;Behavior;behavioral outcome;Brain;Brain region;cardiometabolism;Caring;Centers for Disease Control and Prevention (U.S.);Cervical Intraepithelial Neoplasia;Child;Child Health;clinical research site;Cognitive;cohort;Cohort Studies;Communities;Data Analyses;data management;data resource;design;Development;Disease;Disease remission;Effectiveness;emotion regulation;emotional behavior;Epidemiologic Methods;Epidemiology;experience;Exposure to;Grant;Growth;Guidelines;Health;Health education;HIV;HIV Infections;HPV-High Risk;Human papilloma virus infection;Human Papillomavirus;in utero;Individual;Infant;Infant Health;Infection;Infrastructure;Life Cycle Stages;Long-Term Effects;Monitor;multidisciplinary;Natural History;neurodevelopment;Neurologic;Oral health;oral HPV;Outcome;Pediatric HIV/AIDS Cohort Study;Perinatal;perinatal HIV;Persons;Pharmaceutical Preparations;Population;postnatal;Pregnant Women;Prevalence;Prevention;Program Research Project Grants;programs;Prospective, cohort study;Protocols documentation;reproductive;Research Project Grants;Risk;Risk Factors;Safety;Series;Site;social factors;Statistical Methods;structural determinants;success;Testing;Toxic effect;transition to adulthood;transmission process;treatment response;Vaccinated;young adult;young man;young woman;Youth

PROJECT_TITLE: Pediatric HIV/AIDS Cohort Study (PHACS) 2020

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AARR-J(40)]


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Hematology;Human Genome;Lung;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Telomere dysfunction due to impaired telomere maintenance leads to cellular senescence and underlies many age-related human diseases. We will develop new approaches and a unique resource to advance genomic studies of the consequences of telomere biology on the human medical phenome. These studies will have important implications in understanding the role of telomere shortening in disease and the normal aging process.

PI_NAMEs: COGAN, JOY D (contact);GAMAZON, ERIC R

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;African;Age;age-related disease;Aging;aging biomarker;aging process;aging related disease;Alzheimer's Disease;Aplastic Anemia;Atlases;biobank;Biocompatible Materials;Biological;Biological Markers;Biology;biomarker discovery;Bone marrow failure;Cardiovascular Diseases;Cell Aging;Cell division;cell type;Cells;Chromosomes;Chronic Kidney Failure;Chronic Obstructive Pulmonary Disease;Clinical;clinical phenotype;cohort;Communities;Complex;Data;data resource;Data Set;Data Sources;Degenerative polyarthritis;Dementia;Dependence;design;Diagnostic;diagnostic tool;Dilated Cardiomyopathy;Disease;disease phenotype;disease-causing mutation;disorder risk;Disparity;DNA;drug repurposing;Dyskeratosis Congenita;Dysmyelopoietic Syndromes;Early Diagnosis;Electronic Health Record;Environment;Family;Functional disorder;Genes;Genetic;genetic architecture;Genetic Diseases;Genetic study;Genome;genome sequencing;Genomic DNA;Genomics;Genotype;Genotype-Tissue Expression Project;Human;human subject;Hypertrophy;idiopathic pulmonary fibrosis;Impairment;Individual;insight;inter-individual variation;kidney fibrosis;large datasets;Length;Life Style;Link;Liver diseases;Liver Fibrosis;Longevity;Lung Diseases;lymphoblast;Medical;Methodology;Methods;Modeling;multiple omics;Myeloid Leukemia;Myocardial;non-genetic;normal aging;novel;novel strategies;Nucleoproteins;Organ;Osteoporosis;Parkinson Disease;Patients;Peripheral Blood Mononuclear Cell;phenome;phenomics;Phenotype;phenotypic data;Population;Premature aging syndrome;Process;Proliferating;public database;Pulmonary Fibrosis;Regulation;Reperfusion Injury;Reporting;Research;Research Personnel;Resources;response;Risk;Role;Sampling;secondary analysis;senescence;Severities;Syndrome;telomere;Telomere Maintenance;Telomere Shortening;TINF2 gene;Tissue Banks;Tissues;trait;transcriptome;Underrepresented Populations;Validation;Variant;Whole Blood;whole genome;Work

PROJECT_TITLE: Genomic Basis of Telomere Length Regulation and Consequences for Complex Traits

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-M(02)M]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;HIV/AIDS;Health Services;Hepatitis;Hepatitis - B;Hepatitis - C;Infectious Diseases;Liver Disease

ORG_CITY: SAN DIEGO

ORG_NAME: BIG EYE DIAGNOSTICS, INC.

ORG_STATE: CA

PI_NAMEs: BIAMONTE, MARCO ANTONIO (contact)

PROJECT_TERMS: antibody detection;Chronic;Cirrhosis;co-infection;Contracts;cost;Diagnosis;Diagnostic;Diagnostic tests;Disease Progression;global health;Health Services Accessibility;Hepatitis B;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Virus;Hepatitis C;Hepatitis C virus;HIV;HIV diagnosis;HIV Infections;HIV/HCV;Home;Infection;lateral flow assay;Morbidity - disease rate;mortality;Pathogenesis;Patients;Population;prototype;response;Risk;screening;Services;social;transmission process;Viral hepatitis;Viral Load result

PROJECT_TITLE: An Easy-to-Use, Low-Cost Triplex RDT for the Simultaneous Diagnosis of HBV, HCV, AND HIV Infection, Compatible with Field Use in LMICS and At-Home Use in the US


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Precision Medicine;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: MARSHFIELD

ORG_NAME: MARSHFIELD CLINIC RESEARCH FOUNDATION

ORG_STATE: WI

PI_NAMEs: EDWARDS, DOROTHY FARRAR;HEBBRING, SCOTT JOSEPH (contact)

PROGRAM_OFFICER_NAME: ASPAAS, NAOMI ANTOINETTE

PROJECT_TERMS: Achievement;Address;Alaska Native;Alaska Native population;American Indian Population;American Indians;Area;career;Clinic;Collaborations;Communities;Community Health Services;community partners;Community Services;Custom;design;Education;Educational Materials;Ensure;Epidemiology;Excision;faculty research;Federal Government;Foundations;Future;Goals;Health;health equity;Health Services;Health system;Home;Indigenous;indigenous community;Individual;infrastructure development;Institution;interest;intertribal;Laws;medical schools;Methods;Mississippi;Native American Tribe;Native Americans;Native-Born;Outcome;outreach;Persons;Precision Health;precision medicine;Process;programs;Recording of previous events;Research;Research Infrastructure;Research Institute;Research Personnel;Reservations;resilience;Resistance;Resources;response;Rural;Scientist;service organization;service providers;Services;Social Work;State Government;Students;Time;Training;Training and Education;Training Programs;Treaty;Tribal Council;tribal health;tribal lands;tribal leader;tribal Nation;tribal organization;Tribes;Trust;Universities;urban Native American;Vision;Wisconsin;Work

PROJECT_TITLE: Area of Interest 3: Engage Tribal Nations and Urban and Non-Tribal Land Based AI/AN Populations in Wisconsin


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Lymphatic Research;Nutrition

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Lymphangiogenesis is crucial for fat absorption, yet little is known about the absorptive muscular-lacteal program of the regenerative intestinal villus. We find that loss of Pitx2 in mice disrupts this muscular-lacteal complex and impairs lymphatic transport of lipids, shunting them instead to the portal vein and liver, where they cause non-alcoholic fatty liver disease (NAFLD). While this system can be used as a model of the most common human liver disorder, our current work will define basic mechanisms underlying muscular-lacteal formation, self-renewal, and their impact on portal circulation, which are crucial to understanding and targeting fat absorption pathways in multiple gut diseases.

PI_NAMEs: KURPIOS, NATASZA A (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Ablation;absorption;Address;Adult;Aging;antagonist;Antibiotics;ATP binding cassette transporter 1;Biological Assay;Blood;Blood capillaries;Blood Vessels;CDH5 gene;Cell Lineage;Cell secretion;Cells;Cholesterol;Chylomicrons;Circulation;Complex;Contracts;Development;Dextrans;Diabetes Mellitus;Dietary Fats;Disease;Endothelial Cells;Endothelium;Epithelium;Fatty acid glycerol esters;fatty liver disease;feeding;Fibroblasts;Functional disorder;genetic manipulation;Growth Factor;gut homeostasis;High Density Lipoproteins;High Fat Diet;Homeostasis;Human;Image;Impairment;Injury;interest;Intervention;intestinal villi;Intestines;Knowledge;lacteal;Left;Life;Ligands;Light;Link;lipid transport;Lipids;Liver;Liver diseases;liver function;Lymphangiectasis;Lymphangiogenesis;Lymphatic;Lymphatic Capillaries;lymphatic development;lymphatic dysfunction;lymphatic vasculature;lymphatic vessel;Maintenance;Mediating;Mesenchymal;Mesenchyme;Metabolic Diseases;Microbe;Modeling;Morphogenesis;Mus;Muscle;Muscle Development;Muscle function;muscle repair;mutant;Mutant Strains Mice;Myofibroblast;Natural regeneration;Nature;non-alcoholic fatty liver disease;notch protein;NOTCH3 gene;Nutrient;Obesity;Organ;Organogenesis;Pathway interactions;Pattern;Permeability;Pharmaceutical Preparations;Physiology;Play;Portal vein structure;postnatal;Process;progenitor;programs;regenerative;repaired;Reporting;Research;Role;Science;self-renewal;Shunt Device;Signal Transduction;single cell analysis;Smooth Muscle;Smooth Muscle Myocytes;Source;star formation;System;Tenascin;Testing;Therapeutic Intervention;therapy development;trafficking;transcription factor;uptake;Vancomycin;Vascular blood supply;VEGFA gene;Venous;villin;Villus;Work

PROJECT_TITLE: Morphogenetic mechanisms of intestinal lymphatic smooth muscle-lacteal complex function and dysfunction

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ORG_CITY: DURHAM

ORG_NAME: BAEBIES, INC.

ORG_STATE: NC

PI_NAMEs: NG, RAINER  (contact)

PROJECT_TERMS: Blood specimen;Chronic;Cirrhosis;co-infection;Contracts;cost;Detection;Diagnostic;Disease Progression;Fingers;global health;Health Services Accessibility;Healthcare;Hepatitis B;Hepatitis B Surface Antigens;Hepatitis B Virus;Hepatitis C virus;HIV;HIV diagnosis;HIV-1;HIV/HCV;Immunoassay;Infection;Molecular;Morbidity - disease rate;mortality;novel;Pathogenesis;Patients;Population;response;Risk;screening;Self Administration;Services;social;Testing;transmission process;Viral hepatitis;Viral Load result

PROJECT_TITLE: A Simple Multiplexed Platform for Self-Administered HIV and Hepatitis B Testing


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Precision Medicine;Social Determinants of Health

ORG_NAME: UNIVERSITY OF CHICAGO

PI_NAMEs: AHSAN, HABIBUL  (contact);ASCHEBROOK-KILFOY, BRISEIS A;SHAH, HASSAN ;ZHOU, XIAO YI

PROGRAM_OFFICER_NAME: LOPEZ-CLASS, MARIA

PROJECT_TERMS: Acceleration;Accounting;Adult;Age;All of Us Research Program;Amber;Area;Arthritis;Automobile Driving;Award;Awareness;Biomedical Research;career;Catchment Area;Cessation of life;Chicago;Childhood;Church;Clinical;Clinical Informatics;clinical phenotype;clinical research site;cohort;Collaborations;Collection;Communities;community empowerment;Community Health;community organizations;community partnership;community-centered;Complex;Computers;Coronary heart disease;COVID-19 pandemic;cultural competence;Data;data exchange;data quality;Dedications;Dementia;demographics;digital;digital technology;disability;Disease;disparity reduction;Education;Electronic Health Record;Electronic Mail;Enrollment;Ensure;Environmental Exposure;epidemiology study;Equity;equity, diversity, and inclusion;Ethnic Origin;Ethnic Population;Evaluation;Event;expectation;experience;Family;flexibility;follow-up;Friends;Funding;Genetic;Genomics;Geography;Goals;Graduate Education;Greenland;Hand;Health;Health care facility;health disparity;health equity;Health Personnel;Health Sciences;Health Service Area;Health system;Health Technology;Healthcare;Healthcare Systems;Hour;Human;human disease;Illinois;implementation strategy;improved;Income;Indiana;Infrastructure;innovation;insight;Institution;interest;Internet;interoperability;Investments;Knowledge;Leadership;life span;Link;Malignant Neoplasms;member;Methods;metropolitan;mHealth;Minority Groups;Minority-Serving Institution;Modality;Municipalities;Observational epidemiology;Operations Research;outreach;Participant;patient population;Patients;Pediatrics;Performance;Persons;Physicians;Play;podcast;Population;population based;population health;Population Heterogeneity;Positioning Attribute;Precision Health;precision medicine;Prevention;programs;Protocols documentation;Provider;Race;racial population;recruit;Research;Research Activity;Research Personnel;Residential Facilities;resilience research;Resources;response;Role;Rural;Rural Population;Saliva;Schools;Science;Scientist;Services;Site;skills;Source;Stroke;Structure;Students;suburb;success;synergism;System;Target Populations;Telephone;Text Messaging;Training;Training Programs;trend;undergraduate education;United States;United States National Institutes of Health;Universities;Voice;web site;Work

PROJECT_TITLE: The Illinois Precision Medicine Consortium (IPMC) All of Us Research Program Site


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PI_NAMEs: LAMB, BRUCE T (contact)

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: Acceleration;Accounting;Achievement;Administrator;Alzheimer's Disease;Alzheimer's disease model;Animal Model;Area;Benchmarking;Bioinformatics;Biological Assay;Communication;Communities;cost;Data;data management;data standards;data structure;Dedications;Development;disease model;Ensure;Evaluation;Extramural Activities;Feedback;Fostering;Funding;Generations;Goals;Grant;Granulocyte-Macrophage Colony-Stimulating Factor;Head;improved;Indiana;Joints;Laboratories;Late Onset Alzheimer Disease;Leadership;Measures;Medicine;meetings;member;Mission;model organism;Modeling;Monitor;Mus;neuroimaging;operation;Oral;Peer Review;Preclinical Testing;programs;Progress Reports;Prophylactic treatment;Publications;Recommendation;Reporting;Research;Research Personnel;Resources;Staging;success;synergism;therapy development;Time;timeline;United States National Institutes of Health;Universities;Update;uptake;wasting;Work;Writing

PROJECT_TITLE: Administrative and Coordination Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: DETROIT

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE O6-methylguanine-DNA methyltransferase (MGMT) plays a prominent role in DNA adduct repair that limits the mutagenic and cytotoxic effect of alkylating agents. The goal of this research project is to apply biodegradable small-sized polymer for targeted delivery of DNA MGMT inhibitor with combination of TMZ and radiation therapy for real time monitoring of response to the treatment. Success in our study in preclinical animal tumor models should provide us with novel DNA inhibitors and methods to further develop clinical applications of such therapy options for the improved treatment of brain tumors.

PI_NAMEs: ALI, MESER M. (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Address;Affinity;Alcohols;Alkylating Agents;Alkylation;Amino Acids;Animals;Apoptotic;Binding;Biodistribution;Biological Availability;Biological Markers;Blood;Blood - brain barrier anatomy;Brain;Brain Neoplasms;cancer cell;cancer therapy;Carbon;Cell Culture Techniques;Cells;chelation;Chemicals;Chemoresistance;Chlorotoxin;clinical application;Clinical Research;Combined Modality Therapy;Combretastatin A-4;Complex;Copper;Coupled;Curcumin;Cysteine;cytotoxic;cytotoxicity;Development;Diagnosis;Disulfides;Disulfiram;Ditiocarb;DNA;DNA Adducts;DNA Double Strand Break;DNA Repair;DNA Repair Enzymes;Dose;Drug Delivery Systems;Drug Targeting;Effectiveness;efficacy evaluation;Encapsulated;Engineering;Environment;Enzymes;extracellular;FDA approved;Formulation;fractionated radiation;Fractionated radiotherapy;Glioblastoma;Glioma;Goals;Hematology;Heterogeneity;hydroxypropyl-beta-cyclodextrin;Immunohistochemistry;improved;In Vitro;in vivo;inhibitor;Intravenous;Ligands;Magnetic Resonance Imaging;Malignant Glioma;MAPK8 gene;Mediating;Methods;Methyltransferase;MGMT gene;Modeling;Molecular;Monitor;Morphology;multicatalytic endopeptidase complex;nanoparticle delivery;neoplastic cell;novel;Oral;Oral Administration;overexpression;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;Phase II Clinical Trials;phase II trial;Physiological;Play;Polymers;pre-clinical;preclinical study;Prognosis;Prognostic Factor;Protein Methyltransferases;Proteins;radiation resistance;Radiation therapy;real time monitoring;receptor;Recurrent disease;repaired;Reporting;Research;Research Project Grants;Resistance;Reverse Transcriptase Polymerase Chain Reaction;Role;Safety;Serum Proteins;Solubility;Specificity;standard of care;Stomach;success;System;targeted agent;targeted delivery;temozolomide;Testing;therapy resistant;Tissues;Toxic effect;Treatment Efficacy;treatment response;tumor;Tumor Burden;tumor heterogeneity;Ubiquitin;Water;water solubility;Western Blotting;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Targeted drug delivery system to overcome blood-brain barrier and therapeutic resistance to current standard of care in Glioblastoma

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: Congenital birth defects of the eye and retina cause structural malformations and visual impairment that can result in complete blindness. Causative genes have been identified and knowledge of their role in eye formation is providing the foundation for stem cell and regeneration-based treatments for inherited ocular defects, retinal injury, and disease.

PI_NAMEs: LEVINE, EDWARD M (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Address;Affect;Alleles;ATAC-seq;bisulfite sequencing;Blindness;Candidate Disease Gene;Cells;Complete Blindness;Congenital Abnormality;CRISPR/Cas technology;Data;Defect;Development;Disease;disease-causing mutation;early onset;Electroporation;Embryo;Epigenetic Process;Eye;eye formation;Foundations;Gene Expression;Gene Expression Regulation;Gene Silencing;Generations;Genes;Genetic Models;Genetic Recombination;Germ Lines;Harvest;histogenesis;Homeobox;Human;Hyperpigmentation;in vivo;inducible Cre;Inherited;Injury;insight;Knock-in;Knock-out;Knowledge;LacZ Genes;LoxP-flanked allele;Microphthalmos;Mus;mutant;Mutation;Natural regeneration;neurogenesis;Organ;Organogenesis;Output;Phenotype;postmitotic;prevent;Process;Production;progenitor;programs;Proliferating;Property;Regulation;Reporter;Retina;retinal progenitor cell;Role;single-cell RNA sequencing;Specific qualifier value;stem cell proliferation;stem cells;Structural defect;Tamoxifen;Testing;Time;Tissues;transcription factor;transcriptome sequencing;Visual impairment;Visual System;whole genome

PROJECT_TITLE: Vsx2 Dependent Regulation of Retinal Progenitor Cell Properties

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cannabinoid Research;Endocannabinoid System Research;Nutrition;Obesity

ORG_CITY: NEW YORK

ORG_DEPT: CHEMISTRY

ORG_NAME: CITY COLLEGE OF NEW YORK

PHR: Animal studies have demonstrated that the regulation of food intake requires articulation among endogenous cannabinoids (ECs), fatty acid-binding proteins (FABPs), and a peroxisome proliferator- activated nuclear receptor (PPARa), but the macromolecular basis for appetite, satiety, and obesity is poorly understood. This project will probe the solution-state macromolecular structure and function of EC- FABP, EC-PPAR, and FABP-EC-PPAR complexes in vitro at near-physiological concentrations, determining affinities, metabolic fates, molecular binding interfaces, and conformational changes to test proposed mechanisms of EC metabolic signaling. Working as a team with research trainees, our work will help to understand health risks and design future therapies for heart disease, autoimmune disorders, and type-2 diabetes.

PI_NAMEs: STARK, RUTH E. (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Abbreviations;Address;Affinity;Amides;Animal Model;Animals;Appetite Regulation;Applications Grants;Articulation;Autoimmune Diseases;Binding;Binding Proteins;Binding Sites;Biological Assay;Biophysics;career;Cell Nucleus;Chemicals;Chimera organism;Complex;design;Desire for food;Diffusion;Dissociation;Drug Design;Drug Modulation;endocannabinoid signaling;Endocannabinoids;Enterocytes;Enzymes;Esters;Exhibits;experimental study;fatty acid amide hydrolase;fatty acid-binding proteins;Fatty Acids;Fluorescence;Food Intake Regulation;Future;Genetic Transcription;Glycerol;Health;heart disease risk;Heart Diseases;Human;Hydrophobicity;In Vitro;in vitro testing;Inflammation;Intestines;Knock-out;Knockout Mice;Ligand Binding;Ligand Binding Domain;Ligands;Lipase;Liver;Measures;Mediating;member;Metabolic;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;Molecular Structure;Monitor;Mus;neuroprotection;NMR Spectroscopy;Non-Insulin-Dependent Diabetes Mellitus;Nuclear Receptors;Obesity;Outcome;Pain;Pattern;Peroxisome Proliferator-Activated Receptors;Peroxisome Proliferators;Phenotype;Physiological;preference;pressure;programs;Protein Binding Domain;protein complex;protein protein interaction;Proteins;receptor binding;recruit;Regulation;Relaxation;Research;Risk;Role;Satiation;Signal Transduction;Signaling Molecule;Site;Surface Plasmon Resonance;Testing;Thermodynamics;Thinness;thyroid hormone receptor associated protein 220;Titrations;Underrepresented Populations;United States National Institutes of Health;Vertebral column;Work

PROJECT_TITLE: Molecular Drivers of FABP-mediated Endocannabinoid Signaling for Appetite Regulation


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Pregnancy is an opportunity to screen women at high-risk for cardiovascular disease so that prevention strategies can be implemented. Arterial stiffness measured by pulse wave velocity is a marker for cardiovascular disease risk. This study enrolls mother-infant pairs from healthy pregnancies and those complicated by adverse perinatal outcomes to measure maternal and infant arterial stiffness by pulse wave velocity and cardiovascular biomarkers. We will longitudinally estimate cardiovascular disease risk in healthy and medically complicated pregnant women and their infants from birth to three years postpartum.

PI_NAMEs: BOGGESS, KIM A;MEYER, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: REIS, JARED P

PROJECT_TERMS: Address;adiponectin;Adult;adverse outcome;adverse pregnancy outcome;Affect;Age;Aging;arterial stiffness;Biological;Biological Markers;Biological Process;Biological Specimen Banks;Birth;Black Populations;Black race;Blood Pressure;Blood Vessels;Cardiology;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;Cardiovascular system;Cause of Death;Characteristics;Child;Childhood;cohort;Complex;Data;data repository;Diet;Disease;early childhood;Early Diagnosis;Enrollment;Epigenetic Process;ethnic difference;Ethnic Origin;evidence base;Exercise;experience;Family;Female;Fetal Growth Retardation;Future;Gestational Age;Gestational Diabetes;Glycosylated hemoglobin A;Goals;Growth;Gynecologist;health care availability;Healthcare;healthy pregnancy;high risk;High Risk Woman;High-Risk Pregnancy;in utero;Infant;Inflammatory;innovation;Interdisciplinary Study;Interleukin-6;Intervention;Knowledge;Labor Onset;Latina;Latina Population;Life;Life Cycle Stages;Life Style;Link;Lipids;Longitudinal Studies;maternal outcome;Measures;medical complication;microbiome;modifiable risk;Mothers;Multicenter Studies;multidisciplinary;National Heart, Lung, and Blood Institute;neighborhood safety;Not Hispanic or Latino;Obesity;obstetric care;offspring;Patients;perinatal outcomes;Physiologic pulse;Physiology;post pregnancy;postnatal;postpartum care;Postpartum Period;Postpartum Women;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy hypertension;Pregnant Women;Prenatal care;prevent;Prevention;Prevention strategy;primary outcome;Primary Prevention;prospective;Proteomics;Public Health;Publishing;Pulse Rates;Questionnaires;Race;racial difference;racial diversity;Recommendation;resilience;Risk Factors;risk prediction;risk stratification;screening;sex;Sex Differences;social;Socioeconomic Status;Sports;success;Testing;Time;Vascular Diseases;Weight;Woman;Women's Health;Workplace

PROJECT_TITLE: Arterial stiffness in mother/infant dyads: Life course approach to prevent cardiovascular disease

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PI_NAMEs: BIRD, JEREMY GILBERT (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: 7-methylguanosine;Adenosine;Affinity;Bacteria;Biological Process;Biology;Cell Cycle;Cell Physiology;Cells;chemical group;Chemicals;Chemistry;Dinucleoside Phosphates;Escherichia coli;Escherichia coli Proteins;experimental study;Follow-Up Studies;fungus;Gene Expression;Label;Mass Spectrum Analysis;Metabolic;Methodology;Methods;Modification;next generation sequencing;Niacinamide;novel;Phase;Play;Proteins;RNA;RNA Caps;Role;Structure;Therapeutic;tool;tool development;Transcript;transcriptome sequencing;Uridine Diphosphate N-Acetylglucosamine;Uridine Diphosphate Sugars;Virus;Work

PROJECT_TITLE: Development of tools to identify and characterize UDP-Sugar metabolite RNA caps


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pain Research;Stroke

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Shoulder pain occurs in 30-70% of patients after stroke, contributes to depression, interferes with motor recovery, and leads to decreased quality of life. However, the cause of the myofascial dysfunction has not been elucidated leading to missed opportunities for early diagnosis and variable success with treatment. This project is of significant public health importance, because it will develop quantitative imaging biomarkers of myofascial tissues and assess their ability to monitor responses and predict outcomes in post stroke shoulder pain, and aligns with the NIH HEAL Initiative to bolster research to improve treatment, prevention of opioid misuse and opioid use disorder, and enhance pain management.

PI_NAMEs: RAGHAVAN, PREETI  (contact)

PROGRAM_OFFICER_NAME: TUTTLE, ALEXANDER H

PROJECT_TERMS: Area;Articular Range of Motion;Biological Markers;Chronic;Clinic;Clinical Trials;Cumulative Trauma Disorders;Deep Fascia;Development;Disaccharides;Early Diagnosis;efficacy evaluation;Extracellular Matrix;Fascia;follow-up;Friends;Functional disorder;Glucuronic Acids;Glycosaminoglycans;Helping to End Addiction Long-term;Human;Hyaluronic Acid;Hyaluronidase;hydrophilicity;Image;imaging biomarker;improved;infraspinatous muscle;Injections;Intramuscular;joint mobilization;Joint structure of shoulder region;Lubricants;Magnetic Resonance Imaging;Maps;Measurement;Measures;Mental Depression;Monitor;motor recovery;Muscle;Muscle Contraction;muscle stiffness;Normal saline;opioid misuse;opioid use disorder;outcome prediction;Pain;Pain Free;Pain management;Pain Measurement;Painless;Paresis;Patients;Pattern;pectoralis major muscle;Phase;Physiological;Placebos;Polymers;post stroke;Prevention;primary endpoint;primary outcome;Public Health;Quality of life;quantitative imaging;quantitative ultrasound;Recombinants;Relaxation;Research;response;Rotation;Severities;Shock;Shoulder;Shoulder Pain;Side;spasticity;Stretching;success;Testing;Texture;Time;Tissues;tool;transmission process;treatment response;Ultrasonography;ultrasound;United States National Institutes of Health;viscoelasticity

PROJECT_TITLE: Quantifying and Treating Myofascial Dysfunction in Post Stroke Shoulder Pain


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Building Research Capacity at Institutions with Limited NIH Funding;Childhood Obesity;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

ORG_STATE: AR

PI_NAMEs: AYERS, BRITNI LEE (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Arkansas;Birth;Birth Records;Caring;Cesarean section;Communities;Counseling;culturally appropriate intervention;delivery complications;disorder risk;Effectiveness;ethnic minority;evidence base;Exclusive Breastfeeding;experience;feeding;Gestational Diabetes;gestational weight gain;Glucose Intolerance;Health;health disparity;Healthcare Systems;Impairment;implementation determinants;implementation evaluation;implementation outcomes;Incidence;Infant;Infant Health;innovation;Life;Low Birth Weight Infant;Maternal Health;medical complication;Metabolic Diseases;mobile health clinic;Modeling;Obesity;obesity in children;obesity prevention;obesity risk;Outcome;Pacific Islander;perinatal outcomes;personalized care;poor health outcome;Population;Pre-Eclampsia;Pregnancy;Premature Birth;prenatal;Prenatal care;programs;racial minority;rapid infant weight gain;Recommendation;Risk;Services;Standard Model;Supportive care;Transportation;United States;Visit;Woman;Work

PROJECT_TITLE: Exploring the Feasibility of a Group Prenatal Program, Kommour Prenatal, to Reduce Maternal and Infant Health Disparities among Marshallese Women


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Nutrition;Obesity;Pediatric;Physical Activity;Pregnancy;Prevention;Rural Health;Social Determinants of Health;Women's Health Research

PI_NAMEs: JANSEN, LISA TJORVEN (contact)

PROJECT_TERMS: Address;Adherence;Adult;Affect;Arkansas;Behavior;Behavior Control;Behavioral;Biofeedback;Cardiovascular Diseases;Child;Chronic Disease;Continuous Glucose Monitor;cost effective;Counseling;Data;Diabetes Mellitus;Diagnosis;Diet;Eating;efficacious intervention;efficacy testing;Elements;experience;feasibility trial;Feedback;Future;gestational weight gain;glycemic control;group intervention;Health;High Prevalence;Hyperglycemia;improved;Individual;Intervention;Life Style Modification;lifestyle intervention;Link;low socioeconomic status;Maternal and Child Health;maternal obesity;Metabolic syndrome;Monitor;Mothers;Obesity;obesity in children;obesity prevention;offspring;Outcome;Overweight;Pattern;Physical activity;pilot trial;Pregnancy;Pregnancy Complications;pregnant;Pregnant Women;Prenatal care;Procedures;Process Measure;racial minority;Randomized;Replicating Effective Programs;Reporting;Research;Research Design;Risk;rural area;Self Management;sensor;tool;Treatment Efficacy;uptake;urban area;Visit;Vulnerable Populations;wearable device;Woman;Work

PROJECT_TITLE: Glycemic Pattern Biofeedback as Lifestyle Modification Tool in Pregnancies with Obesity


NIH_SPENDING_CATS: Aging;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Ovarian Cancer;Prevention;Prostate Cancer;Rare Diseases;Urologic Diseases;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Genetic studies have found hundreds of common genetic variations in the population that affect a person’s risk of a multitude of different diseases including cancer but for most of these variants, we neither know the functional reasons why they cause disease, nor the genes they interact with to drive disease development. In this proposal, we plan to use a combination of functional assays, genetic information and computational methods to work out the function of known genetic variants that influence breast, prostate and ovarian cancer risk because these cancers share common risk factors and biology and there are strong reasons to believe that some of the same genes are responsible for causing all three cancer types. We hope these approaches and the methods we use can work out the function of genetic variants and genes that cause disease, leading to clinical benefits to individuals on a population level, particularly in developing new risk prediction and prevention strategies to reduce breast, prostate and ovarian cancer incidence.

PI_NAMEs: FREEDMAN, MATTHEW L;GAYTHER, SIMON ANDREW (contact);KAR, SIDDHARTHA

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: 8q24;Affect;African American;Asian;Automobile Driving;Biological;Biological Assay;Biology;BRCA1 gene;BRCA2 gene;Breast;Breast Cancer Model;c-myc Genes;cancer risk;cancer type;Candidate Disease Gene;candidate identification;candidate validation;case control;Cellular biology;chromosome conformation capture;CISH gene;Clinical;Code;Complex;Computing Methodologies;CRISPR interference;CRISPR/Cas technology;Data Set;Development;Disease;disorder risk;DNA;Dryness;Elements;Epidemiology;epigenomics;Etiology;European;Experimental Models;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;gene interaction;Gene Targeting;Genes;Genetic;genetic association;Genetic Code;genetic information;Genetic Predisposition to Disease;Genetic study;genetic variant;Genetic Variation;genome editing;genome wide association study;genome-wide;genomic locus;Genotype;Goals;Hispanic ancestry;Hormonal;Human;Human Genetics;in vitro Model;Incidence;Individual;knock-down;Leadership;Luciferases;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Mediating;Mendelian disorder;Meta-Analysis;Methodology;Methods;Modeling;Molecular;molecular marker;Molecular Target;Mutation;neoplastic;novel;Open Reading Frames;Ovarian;overexpression;Pathogenesis;Pathway Analysis;Pathway interactions;Persons;Phenotype;pleiotropism;Population;Positioning Attribute;Predisposition;Prevention strategy;Prostate;Regional Cancer;Regulator Genes;Regulatory Element;Research Personnel;Resolution;Risk;Risk Factors;risk prediction;risk variant;Role;screening;Susceptibility Gene;Tissues;trait;Transcriptional Regulation;transcriptomics;Untranslated RNA;Variant;Work

PROJECT_TITLE: Common biology underlying pleiotropic breast, prostate and ovarian cancer risk loci

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: This proposal will provide new understanding of the progenitor cell function in homeostatic and diseased LGs. Our study will provide new information how lacrimal gland epithelial and progenitor cells sense inflammation and contribute to development of dry eye condition. We are confident that our new approach targeting inflammasome pathway and lacrimal gland progenitor cells will lead to development of a new therapies that improve lacrimal gland function during chronic inflammation.

PI_NAMEs: MAKARENKOVA, HELEN P. (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acinar Cell;Adult;Affect;American;Anti-Inflammatory Agents;aqueous;Blurred vision;Cell Differentiation process;Cell Lineage;Cell Physiology;cell replacement therapy;Cell Transplantation;Cells;Chronic;cytokine;Development;Disease;Dry Eye Syndromes;Dryness;effective therapy;Engraftment;Epithelial Cells;experimental study;eye dryness;Eye Infections;Film;Functional disorder;Genetic;Gland;Glycoproteins;IL18 gene;improved;in vivo;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Injury;Interleukin-1;Ion Channel;Label;Lacrimal gland structure;Mediating;Molecular;mouse model;Multiprotein Complexes;Myoepithelial cell;Nature;novel strategies;novel therapeutics;Pathway interactions;progenitor;regenerative cell;repaired;response;Risk;Role;stem;stem cell biology;stem cell function;stem cell therapy;Stem cell transplant;stem cells;Symptoms;targeted treatment;Therapeutic;Tissues;Transplantation

PROJECT_TITLE: Lacrimal Gland Repair Using Progenitor Cells


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The tumor microenvironment plays a pivotal role in cancer progression. Our work shows that senescent, noncancer cells contribute to breast cancer tumor progression. Thus, our work will focus on: 1) how these cells change the immune response to a growing breast tumor and metastatic tumor and 2) how eliminating these tumor promoting cells can increase susceptibility to immunotherapy to reduce breast cancer.

PI_NAMEs: STEWART, SHEILA A (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Address;Affect;age related changes;aged;Architecture;Area;Atomic Force Microscopy;beta-Galactosidase;Biological Assay;biophysical properties;biophysical techniques;Biophysics;Blood Vessels;breast cancer progression;Cell Cycle Arrest;cell growth;cell killing;cell motility;Cell Physiology;cell type;Cells;Cessation of life;Collagen;combat;Complex;Data;Development;Elderly;ERBB2 gene;Estrogen receptor positive;Extracellular Matrix;Fibroblasts;Functional disorder;Genetically Engineered Mouse;Health;Heterogeneity;Human;human tissue;Image;Immune;Immune response;Immunocompromised Host;Immunologic Techniques;Immunotherapeutic agent;Immunotherapy;In Vitro;Incidence;Inflammatory;innovation;insight;Lead;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mechanics;Microfluidic Microchips;migration;Modeling;Mouse Mammary Tumor Virus;mouse model;Mus;Mutation;Myofibroblast;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;NK Cell Activation;Noninfiltrating Intraductal Carcinoma;novel;Organ;Organoids;Phenotype;Play;polyoma middle tumor antigen;Population;Predisposition;Primary Neoplasm;Recurrence;Research;response;Role;second harmonic;senescence;senescence associated secretory phenotype;senolytics;Site;Specimen;Stress;Tail;Therapeutic;Tissues;transplant model;triple-negative invasive breast carcinoma;tumor;Tumor Cell Migration;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;Veins;Woman;Work

PROJECT_TITLE: Senescent CAFs in Breast Cancer Progression

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ORG_CITY: ATLANTA

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative: Loss of muscle mass and function causes decreased mobility, falls, and fractures in elderly people, and though no effective therapy currently exists, chemical compounds called “indoles,” derived from the gut bacteria, limit decline in muscle function and mass and promote mobility in aging animals. Aim 1 will determine how indoles protect the muscle contractile machinery during aging; Aim 2 will determine if additional indole-regulated pathways enhance mobility during aging; Aim 3 will determine whether indoles promote the function of the mitochondria, the powerhouse of the cell whose function declines during aging whose function is dysregulated during aging. These studies will facilitate development of indoles as therapeutics for elderly people at risk for falling or losing mobility.

PI_NAMEs: BENIAN, GUY MARTIN;KALMAN, DANIEL  (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Achievement;Address;Affect;Age;age related;age related decline;aged;Aging;animal old age;Animals;Aryl Hydrocarbon Receptor;Bacteria;Bed rest;Biochemical;Bioenergetics;Biological Markers;Biosensor;Blood;burden of illness;Caenorhabditis elegans;Cells;Cessation of life;Characteristics;Chemicals;Citric Acid Cycle;clinical practice;Clinical Trials;cohort;commensal bacteria;commensal microbes;Cytoplasmic Protein;Data;Development;Disease;DNA Repair;Down-Regulation;Drosophila genus;dysbiosis;effective therapy;Elderly;Electron Transport;Exhibits;fall risk;falls;fly;Fracture;frailty;functional food;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic approach;genome integrity;Geriatrics;Germ Cells;Goals;Growth;gut bacteria;handicapping condition;Health;Health Promotion;healthspan;Heat-Shock Proteins 90;Human;improved;improved mobility;Individual;Indoles;Ingestion;Intervention;intestinal barrier;intestinal homeostasis;juvenile animal;Kale - dietary;Mammals;Mediating;men;metabolomics;microbiota;Mitochondria;Mitochondrial DNA;Mitochondrial Proteins;Mobility decline;Molecular;Molecular Chaperones;multicatalytic endopeptidase complex;Mus;Muscle;muscle form;Muscle function;Muscle Proteins;Muscular Atrophy;muscular structure;mutant;Myofibrils;Myosin ATPase;Nematoda;old mice;Organism;osteoporosis with pathological fracture;Pathway interactions;Patients;Persons;physically handicapped;Plasma;Populations at Risk;preservation;prevent;Process;Production;protective effect;protein aggregation;Protein Import;Proteins;proteostasis;Publishing;reproductive;Resistance;Respiration;Respiratory Chain;Respiratory physiology;RNA Interference;Sampling;Sarcomeres;sarcopenia;Skeletal Muscle;Specific qualifier value;stem cells;Stress;Striated Muscles;System;systemic inflammatory response;Testing;Therapeutic;transcriptomics;Translations;Ubiquitin;Up-Regulation;Work

PROJECT_TITLE: Indoles from commensal microbiota promote mobility during aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

PHR: PROJECT NARRATIVE CAR-T cell therapy drafts a patient's immune system (cytotoxic T cells) to target and kill tumors and its combination of pin-point specificity and broad efficacy has translated into exciting clinical data and revolutionary treatment for certain blood cancers. The major impediment to widespread use of CAR-T therapy remains its cost, which approaches $500K, a slow manufacturing process and huge regulatory hurdles for facilities that manufacture CAR-T cells. We will develop biomaterial approaches to CAR-T cell therapy, including improved methods to reprogram cells, to release cells quickly to tumors, and even to generate the CAR-T cells entirely within a patient's own body.

PI_NAMEs: BRUDNO, YEVGENY  (contact)

PROGRAM_OFFICER_NAME: SALOMON, RACHELLE

PROJECT_TERMS: 3-Dimensional;Achievement;Adopted;Alginates;Allogenic;Antibodies;Architecture;Autologous;B lymphoid malignancy;Biocompatible Materials;Biological Assay;biomaterial compatibility;bioscaffold;CAR T cell therapy;CD28 gene;CD3 Antigens;Cell Count;Cell Differentiation process;Cell Physiology;Cell Reprogramming;Cell Therapy;Cells;Cellular biology;cellular transduction;Centrifugation;Characteristics;chimeric antigen receptor;chimeric antigen receptor T cells;Circulation;Clinical;Clinical Data;clinically relevant;Coculture Techniques;confocal imaging;cost;crosslink;CXCL10 gene;cytokine;Cytotoxic T-Lymphocytes;Data;density;design;Devices;Disease;Dose;Drug Delivery Systems;Encapsulated;Engineering;Engraftment;Ensure;Generations;Genetic;Goals;graft vs host disease;Hematopoietic Neoplasms;Immune system;immunogenicity;Implant;implantation;improved;In Situ;In Vitro;in vivo;Interleukin-2;Interleukins;Kinetics;Lentivirus;Lentivirus Vector;Longevity;Lymphocyte;Lymphoma;manufacture;manufacturing facility;manufacturing process;mechanical properties;Mediating;Medical;Methods;Modeling;multidisciplinary;Mus;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Physiological;Polybrene;Porosity;preclinical efficacy;prevent;procedure cost;Procedures;Process;Production;programs;Proliferating;Proteins;Protocols documentation;recruit;Research;response;Retroviral Vector;scaffold;Signal Transduction;Solid Neoplasm;Specialist;Specificity;success;System;T-Cell Activation;T-Lymphocyte;Technology;Testing;Therapeutic;Time;transduction efficiency;Translating;translational potential;tumor;Tumor Burden;Viral;Viral Vector;Xenograft Model

PROJECT_TITLE: Biomaterial Scaffolds for Ex Vivo and In Situ CAR-T Cell Production

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: Aurora

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative This three-arm individual randomized controlled effectiveness trial aims to reduce childhood obesity disparities in children ages 5-8 (n=510) from low income and diverse households by increasing family meal quality (i.e., diet quality, interpersonal atmosphere) and quantity (i.e., family meal frequency). Innovative methodology (e.g., ecological momentary assessment (EMI), video feedback) will be used in partnership with primary care clinics and Community Health Workers to test three arms: (1) EMI; (2) EMI+Home Visiting (HV); and (3) EMI+HV+ Video Feedback. Findings will result in a new model for childhood obesity treatment in primary care.

PI_NAMEs: BERGE, JERICA M (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Adult;African American;Age;arm;Atmosphere;Behavior;behavior change;Body mass index;Cellular Phone;Child;clinical practice;Communities;Community Health Aides;community partners;Coping Skills;Cost Analysis;cost effective;cost effectiveness;Data Collection;Diet;dietary;Dietary intake;Disparity;Ecological momentary assessment;Education;effectiveness trial;Eligibility Determination;Environment;Ethnic Origin;Evidence based intervention;Family;Family member;family support;Feedback;feeding;food environment;food quality;Frequencies;Health behavior;Health Technology;Healthy Eating;High Prevalence;Hispanic;Home;Home visitation;Household;implementation intervention;Income;indexing;Individual;innovation;Intervention;intervention effect;Intervention Studies;Longitudinal Studies;Low income;Maintenance;Measures;meetings;Methodology;Methods;mHealth;Minority;Modeling;Native Americans;Obesity;obesity in children;obesity risk;obesity treatment;Outcome;Overweight;Parents;Participant;Pattern;Phase;Pilot Projects;post intervention;Primary Care;primary care clinic;primary care setting;primary outcome;Procedures;Protocols documentation;Race;Randomized;Readiness;recruit;Research;Risk;secondary outcome;Self Efficacy;sex;Siblings;Socioeconomic Status;Stress;success;Systems Theory;Testing;three-arm study;Time;video visit;Visit;Weight

PROJECT_TITLE: Reducing Childhood Obesity Using Ecological Momentary Intervention (EMI) and Video Feedback at Family Meals

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(JA)]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Genetic Testing;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Patient Safety;Prevention;Rare Diseases

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Pancreatic cystic neoplasms (PCN) represent a common incidental finding with a prevalence of up to 24% in adults, and some PCN carry significant risk for malignancy. Current guidelines for surveillance and surgical intervention rely on symptoms and imaging features, and lead to surgical overtreatment. Development of effective early detection biomarkers in blood or cyst fluid could more accurately differentiate high risk PCN from low risk lesions, and lead to early detection of lesions with high-grade dysplasia or early stage malignancy for surgical intervention.

PI_NAMEs: EVERETT, JESSICA ;SIMEONE, DIANE M (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Acceleration;Address;Adult;Alcohol consumption;Artificial Intelligence;Biological Markers;biomarker panel;biomarker performance;biomarker signature;biomarker validation;Blinded;Blood;blood-based biomarker;Breakthrough device;CA-19-9 Antigen;Cancer Detection;Clinical;Clinical Data;cloud based;cloud platform;cohort;Collaborations;Collection;combinatorial;Cyst;Cyst Fluid;Data;Data Collection;data integration;data resource;Dedications;design;Development;Diabetes Mellitus;Diagnosis;Disease;Duct (organ) structure;early detection biomarkers;Early Diagnosis;Early identification;Evaluation;Excision;Funding;Future;Genetic;genetic testing;Germ Lines;Glycosylated hemoglobin A;Goals;Guidelines;High grade dysplasia;high risk;high risk population;Image;improved;Incidental Findings;Individual;Industry;Infrastructure;Laboratories;learning strategy;Lesion;Link;Longitudinal cohort study;Machine Learning;Magnetic Resonance Imaging;Main pancreatic duct;Malignant neoplasm of pancreas;Malignant Neoplasms;member;model development;Modeling;Mucinous Neoplasm;multimodal data;Neoplasm Metastasis;novel;Operative Surgical Procedures;overtreatment;pancreas imaging;Pancreatic cystic neoplasia;Pancreatic Ductal Adenocarcinoma;Pancreatitis;Papillary;Pathology;Patients;Performance;performance tests;Population;Prevalence;prospective;Prospective cohort;Protocols documentation;radiological imaging;Recording of previous events;Research;Research Personnel;Resources;Retrospective cohort;Risk;Risk Factors;risk stratification;sample collection;Sampling;Science;screening;Screening for cancer;Sensitivity and Specificity;serial imaging;Slide;Smoking Status;Standardization;Symptoms;Technology;Testing;tumor progression;Unresectable

PROJECT_TITLE: Biomarker Validation in Pancreatic Cystic Neoplasms


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cervical Cancer;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Pediatric;Prevention;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: CALVERTON

ORG_NAME: INFORMATION MANAGEMENT SERVICES, INC.

PI_NAMEs: GIFFEN, CAROL  (contact)

PROJECT_TERMS: Adult women;Bioinformatics;Cervarix;Contractor;Costa Rica;Data;Data Analyses;data infrastructure;data management;Disease;Dose;Epidemiology;Follow-Up Studies;Gardasil;girls;Goals;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papillomavirus;Immunology;Infection prevention;Longterm Follow-up;Malignant Neoplasms;Natural History;Preparation;prophylactic;Scientific Evaluation;Services;vaccine trial;Vaccines;women's prevention;young adult

PROJECT_TITLE: THE CONTRACTOR SHALL MAINTAIN AND SUPPORT STUDY DATA INFRASTRUCTURE, DATA MANAGEMENT AND DATA PREPARATION, AND ADVANCED STATISTICAL AND BIOINFORMATICS


NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: CINCINNATI

ORG_STATE: OH

PI_NAMEs: GOCKERMAN, BRIAN  (contact)

PROJECT_TERMS: Area;cancer care;Cancer Patient;Cause of Death;Consent;Data;data registry;demographics;Dose;Electronics;follow-up;Guidelines;Health Personnel;Hospitals;Individual;interest;Laws;Life;Malignant Neoplasms;Medical;National Cancer Institute;neoplasm registry;Oncologist;Oncology;Patients;Physicians' Offices;Provider;Recurrence;Reporting;SEER Program;Series;Source;surveillance data;System;Systemic Therapy;transmission process

PROJECT_TITLE: ELECTRONIC CAPTURE OF CANCER CLAIMS DATA FOR THE SEER PROGRAM


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Nanotechnology

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PI_NAMEs: SUN, JINGJING  (contact)

PROJECT_TERMS: Address;Azacitidine;Behavior;Binding;Biodistribution;Biological;Biological Availability;biological systems;Blood Circulation;Cells;Cetuximab;Complex;Coupling;cytotoxicity;Defect;design;Development;Drug Combinations;Effectiveness;Epidermal Growth Factor Receptor;Exhibits;Fibronectins;Formulation;homologous recombination;homologous recombination deficiency;improved;in vivo;inhibitor;Ligands;Liquid substance;Malignant Neoplasms;Modeling;Modification;Molecular Target;Molecular Weight;Monoclonal Antibodies;Morphology;nanocarrier;nanoparticle;nanosized;Nebraska;neoplastic cell;Non-Small-Cell Lung Carcinoma;overexpression;Particle Size;Penetration;Pharmaceutical Preparations;Poly(ADP-ribose) Polymerase Inhibitor;Polymers;Property;Proteins;recruit;Role;Safety;Serum;Serum Proteins;Site;Specificity;spheroids;Structure;Structure-Activity Relationship;targeted agent;Therapeutic;Time;Toxic effect;Treatment Efficacy;tumor;tumor growth;uptake;Work

PROJECT_TITLE: Development of Biodegradable Nanocarrier for Improved Co-delivery of PARPi and DNMTi


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Patient Safety

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE Individuals with Type 1 Diabetes (T1D) are susceptible to repeated episodes of hypoglycemia, which can result in impaired awareness of hypoglycemia (IAH). As a consequence, IAH contributes to diminished recognition of the need for external glucose. This can be a very risky situation for T1D individuals with IAH, possibly leading to coma and in some circumstances, death. The NIDDK is forming the IAH Consortium, which will conduct studies to determine if the most up-to-date management strategies using diabetes technology will restore awareness of hypoglycemia.

PI_NAMEs: CHINCHILLI, VERNON M (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Accountability;acute pancreatitis;Adherence;Adult;Adverse event;Advocacy;Ancillary Study;Awareness;Biological Assay;biomarker selection;Biometry;Blood Glucose;Caregivers;Cessation of life;clinical center;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Collection;college;Coma;Communication;Conduct Clinical Trials;Conflict of Interest;Continuous Glucose Monitor;cost;Data;Data Analyses;Data Coordinating Center;data exchange;data management;Data Management Resources;data submission;design;Development;Devices;Diabetes Mellitus;Digestive System Disorders;drug distribution;Enrollment;Ensure;Evaluation;Exclusion;experience;Family member;Funding;Glucose;Glycosylated hemoglobin A;Health Sciences;Healthcare Systems;Heterogeneity;Hypoglycemia;Impairment;improved;Individual;Institutional Review Boards;Insulin-Dependent Diabetes Mellitus;Internet;Investigational New Drug Application;Kidney Diseases;Laboratories;Lead;Manuals;Manuscripts;Measures;Medical;Medicine;member;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;participant enrollment;Patient Self-Report;Patients;Pennsylvania;Predisposition;Preparation;Procedures;Process;programs;Protocols documentation;Psychometrics;Public Health;Publications;quality assurance;Quality Control;Questionnaires;Randomized;recruit;Reporting;repository;Request for Applications;Research;Research Design;response;restoration;Safety;Safety Management;Sample Size;Security;Site Visit;Statistical Data Interpretation;Support System;System;Technology;Time;United States Food and Drug Administration;United States National Institutes of Health;Universities;Validation;Vendor;Visit;web site

PROJECT_TITLE: The Biostatistics Research Center for the Impaired Awareness of Hypoglycemia Consortium


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

PI_NAMEs: CORNELL, CAROL ELLEN (contact);FAGAN, PEBBLES ;GUY, MIGNONNE CATHERINE

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TITLE: The Center for Research, Health, and Social Justice


NIH_SPENDING_CATS: Complementary and Integrative Health;Nutrition;Obesity;Prevention

ORG_CITY: BOSTON

ORG_DEPT: GENETICS

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE Despite all our efforts, the obesity rate continues to rise in the US and worldwide. To stop this trend, we need to understand how it is that some foods cause obesity while others do not. The proposed research is relevant to this public health problem because it aims to determine how foods with different amounts of fat and carbohydrate give rise to different metabolism and ultimately different body weights.

PI_NAMEs: HUI, SHENG  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: absorption;Address;Affect;Animals;Anti-Obesity Agents;Area;Body Weight;Carbohydrates;Cardiovascular Diseases;Chemicals;Citric Acid Cycle;Complex;Consumption;Data;Dependence;Development;Diabetes Mellitus;Diet;diet-induced obesity;dietary;Dietary Carbohydrates;Dietary Fats;Disease;Eating;effective intervention;energy balance;Energy Intake;Energy Metabolism;Equation;Excretory function;experimental study;Fasting;Fat-Restricted Diet;Fatty acid glycerol esters;Fatty Acids;Feces;feeding;Food;Futile Cycling;Gases;glucagon-like peptide 1;Goals;gut microbiome;High Fat Diet;in vivo;Infusion procedures;innovation;Insulin;interdisciplinary approach;Isotopes;ketogenic diet;Knowledge;lipidomics;Macronutrients Nutrition;Mainstreaming;Mass Spectrum Analysis;mathematical model;Measurement;Measures;Metabolic;Metabolism;metabolomics;Modeling;Mus;neglect;novel;Nutrient;Obesity;obesity prevention;pandemic disease;Pathway interactions;Pharmaceutical Preparations;Physiological;Population;preference;Prevention strategy;preventive intervention;Process;protein degradation;Proteins;Public Health;Research;response;Risk Factors;small molecule;stable isotope;Therapeutic;Tissues;Tracer;trend;Triglycerides;Work

PROJECT_TITLE: Fluxomics Studies of the Effect of Diet Composition on Energy Metabolism

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Aging;Sarcopenia

ORG_CITY: IOWA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Age-related skeletal muscle atrophy and weakness, also referred to as sarcopenia, affects millions of people, remains poorly understood, and lacks effective therapy. Toxic protein aggregates accumulate in muscles with sarcopenia, and we have uncovered ULK2 as a new protein required for degradation of protein aggregates in skeletal muscle. Because ULK2 activity is decreased with aging, by studying how ULK2 works we hope to better understand how toxic proteins accumulate in sarcopenia potentially identifying new ways to mitigate muscle atrophy and weakness in the elderly.

PI_NAMEs: LIRA, VITOR A (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Age;age related;age-related disease;age-related muscle loss;aged;Aging;aging population;Autophagocytosis;Autophagosome;Binding;Caenorhabditis elegans;Cells;Characteristics;Development;Drosophila genus;effective therapy;Elderly;experimental study;Functional disorder;gain of function;Genes;Goals;healthspan;Human;Impairment;Life;life span;Mediating;Medical;misfolded protein;Modeling;Molecular;mortality;mouse model;Muscle;muscle aging;Muscle Fibers;muscle form;Muscle Weakness;Muscular Atrophy;Mutation;new therapeutic target;novel;old mice;paralogous gene;Persons;Phenotype;Phosphorylation;Phosphorylation Site;Phosphotransferases;Population;Predisposition;preservation;Process;protein aggregation;protein degradation;Protein Kinase;Proteins;Proteome;Proteomics;proteostasis;proteostasis loss;proteotoxicity;Publishing;Regulation;Research;Rodent;Role;sarcopenia;Signal Pathway;Signal Transduction;Site;Skeletal Muscle;skeletal muscle wasting;skeletal preservation;Stress;Testing;Time;Work;young adult

PROJECT_TITLE: Role of ULK2 in selective protein degradation and protection against sarcopenia

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Aging;Bioengineering;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: NARRATIVE Age-related diseases are together the leading causes of death in the United States, and drugs targeting basic mechanisms of aging have recently entered clinical trials. A hallmark of cellular aging is stochastic genetic and epigenetic drift, where cells gradually accumulate errors in their genomes and epigenomes, leading to cell-type specific aging phenotypes. This project develops computational methods and performs experiments to study how these errors propagate to the levels of transcription and RNA splicing, and how this increase in biological noise relates to known contributors to aging, particularly cellular senescence.

PI_NAMEs: JOHNSON, F. BRAD;ZHANG, NANCY R (contact)

PROJECT_TERMS: Address;Adoption;Age;Age related pathologies;age-related disease;Aging;aging mechanism;aging process;aging related;aging related disease;Alternative Splicing;anti aging drug;ATAC-seq;Automobile Driving;Benchmarking;Biological;Biological Models;Biology of Aging;Cause of Death;Cell Aging;Cell Cycle Arrest;cell injury;cell type;Cells;Chromatin;Clinical Trials;Communities;Computer software;computerized tools;Computing Methodologies;Cytosine;Data;Data Analyses;data modalities;Data Set;detection method;Development;DNA;drivers of aging;Drug Targeting;Endogenous Retroviruses;Epigenetic Process;epigenome;experimental study;Functional disorder;Gene Expression;Generations;Genes;Genetic;Genetic Markers;Genetic Transcription;Genome;Goals;hallmarks of aging;histone modification;Individual;interest;Joints;Knowledge;Mathematics;Measurement;Measures;Methods;Methylation;Mitochondria;Modality;Modeling;multimodality;multiple omics;Noise;open source;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Predisposition;pro-aging;protein aggregation;Publishing;Regulation;Research;Resolution;Retroviridae;RNA;RNA Splicing;Role;senescence;senescent cell;senolytics;single cell analysis;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Statistical Models;stem;stem cell population;Stress;System;Technology;Testing;Time;Tissues;tool;Transcript;transcriptome;transcriptome sequencing;transcriptomics;United States;XCL1 gene

PROJECT_TITLE: Multiomic methods for the characterization of cellular aging

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is responsible for 1 in 3 deaths among older adults, and methods of accurate, equitable, and widely available detection are needed. Digital biomarkers show promise in their ability to discern subtle neuropathological changes in early AD and address limitations of existing detection techniques. This proposal aims to formally evaluate and extend the capabilities of a novel digital biomarker, the Visuospatial Memory Eye-Tracking Test (VisMET), to detect visuospatial memory decline in early AD.

PI_NAMEs: CLIFFORD, GARI DAVID (contact);LEVEY, ALLAN I

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Age;age related;aging brain;Alzheimer disease detection;Alzheimer's Disease;Amyloid beta-Protein;analytical method;Attention;Biological Markers;Brain;Calibration;Cessation of life;Classification;Clinical;Cognition;Cognitive;cognitive change;cognitive function;cognitive process;cognitive testing;cohort;Collection;Data;Data Collection;deep learning;Demographic Factors;Demographic Impact;Detection;detection method;digital;Digital biomarker;digital measure;Disease;Disease Progression;Early Diagnosis;Education;Educational Status;Emotional;Emotions;Enrollment;Equity;executive function;Foundations;Goals;Hippocampus;Image;imaging detection;Impaired cognition;Impairment;improved;Individual;instrument;machine learning algorithm;Measures;Medical;Memory;Memory impairment;Memory Loss;Methods;mild cognitive impairment;Mission;Modeling;multimodality;neuropathology;Neuropsychology;novel;older adult;Participant;Pathologic;Patient Care;Patients;Performance;performance tests;Persons;Population;Population Heterogeneity;pre-clinical;prediction algorithm;processing speed;Public Health;Race;racial population;recruit;Research;research clinical testing;Sampling;screening;sex;Site;Task Performances;tau-1;Techniques;Testing;Time;Universities;Validation;Visual;visual memory;visual tracking;Visuospatial;Work

PROJECT_TITLE: Multimodal Deep Learning to Assess Cognitive Processes and a Validation of a Visuospatial Memory Eye-Tracking Test in Diverse Populations

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurodegenerative

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: New drugs developed to target Alzheimer's Disease and Related Dementias (AD/ADRD) have a 99% failure rate; however, drug repurposing--identifying new uses for existing drugs--offers an alternative approach that can reduce the time, costs, and risks of failure associated with new drug development. The lack of systematic and readily deployable approaches to screen and validate drug repurposing signals represents a critical barrier to the success of leveraging existing public knowledge and clinical data for the advancement of AD/ADRD treatment and prevention. In direct response to the formidable challenge emphasized in PAR-20-156, we propose combining big data with advanced informatic technologies and computational capabilities to develop and share tools which systematically screen, prioritize, and validate drug repurposing candidates and their combinations for AD/ADRD.

PI_NAMEs: FENG, QIPING ;WEI, WEI-QI  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Address;Alzheimer's disease related dementia;Animal Model;Area;Basic Science;Big Data;biobank;Biological;candidate identification;candidate validation;Clinical;Clinical Data;Clinical Trials;Code;Combined Modality Therapy;cost;Data;Data Set;Databases;Diagnosis;Dose;drug candidate;Drug Combinations;drug development;drug repurposing;Drug Screening;Electronic Health Record;Electronic Medical Records and Genomics Network;Emotional;Failure;FDA approved;Financial Hardship;functional genomics;Gender;Gene Expression;Genetic;genetic analysis;Genetic Research;genetic variant;genome wide association study;Genomic approach;Genotype;Human;Hyperlipidemia;Hypertension;Informatics;innovation;Knowledge;Knowledge Portal;Literature;Maps;Medicare claim;Mendelian randomization;mental function;Morbidity - disease rate;Natural Language Processing;new therapeutic target;novel;novel therapeutics;Onset of illness;Outcome;Pathogenesis;Persons;Pharmaceutical Preparations;Phenotype;phenotypic data;Prevention;Process;Proteins;Publications;PubMed;Race;Reporting;Research;response;Risk;screening;side effect;Signal Transduction;Standardization;success;Technology;Terminology;Testing;Time;tool;transcriptome;transcriptomics;United States;United States National Library of Medicine;Validation;virtual;web site

PROJECT_TITLE: Systematically screening and validating drug repurposing candidates for Alzheimer's Disease and Related Dementias


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Burden of Illness;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

ORG_NAME: HEBREW REHABILITATION CENTER FOR AGED

PHR: PROJECT NARRATIVE The proposed research aims to evaluate the effectiveness of the Centers for Medicare & Medicaid Services Transitional Care Management and Chronic Care Management and develop strategies to increase adoption of these services. This research is relevant to public health because the research findings will enable a targeted delivery of resource intensive care management services to Medicare beneficiaries who are most likely to benefit from these services. Thus, it accomplishes the National Institute on Aging's missions and initiatives to improve the health status of older adults and tame rising Medicare expenditure.

PI_NAMEs: KIM, DAE HYUN  (contact);MCCARTHY, ELLEN P

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;Adopted;Adoption;Affect;Age Years;Aging;beneficiary;care coordination;Caregivers;Caring;Characteristics;Chronic Care;chronic care model;Clinic;Clinical;cost;Data;Dementia;design;Development;Disease;dual eligible;Effectiveness;effectiveness evaluation;Elderly;Evaluation;Expenditure;experience;Fee-for-Service Plans;frailty;Geriatrics;Goals;Health;Health Care Costs;health economics;Health Services Research;Health Status;Healthcare Systems;high risk;Home;Hospitals;improved;indexing;Informed Consent;innovation;Intensive Care;Interview;Knowledge;Leadership;Life Expectancy;longitudinal care;Managed Care;Medical;Medicare;Methods;Mission;mortality;multiple chronic conditions;National Institute on Aging;Nurses;older adult;Outcome;Participant;Patient Care Management;Patient Discharge;patient oriented;Patient-Centered Care;Patient-Focused Outcomes;Patients;Perception;Performance;Physiological;Population;practice factors;predictive modeling;Provider;psychosocial;Public Health;Qualitative Research;readmission risk;Research;Resources;Sampling;service delivery;service uptake;Services;Skilled Nursing Facilities;social deprivation;social health determinants;social vulnerability;Structure;targeted delivery;Technology;Testing;Time;Training;treatment as usual;United States Centers for Medicare and Medicaid Services

PROJECT_TITLE: Evaluation of CMS Transitional Care and Chronic Care Management Services: Bridging the Gap and Maximizing Potential

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Aging;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: b. Project Narrative  The hallmarks of aging include stem cell exhaustion and related mitochondrial dysfunction. We have uncovered a critical role for glutamine metabolism in the muscle stem cell through both oxidative and reductive TCA pathways, which become dysfunctional with aging. Our evidence suggests restoration of the glutamine pathway(s) rejuvenates aged stem cell function and improves myogenic capacity.

PI_NAMEs: WHITE, JAMES P. (contact)

PROJECT_TERMS: Affect;Age;age effect;age related;aged;Aging;Amino Acids;cell age;Cell Maintenance;Cell Physiology;Cell Survival;Cellular Metabolic Process;cellular resilience;Citrates;Citric Acid Cycle;Collaborations;conditionally essential amino acid;Critical Pathways;Cytosol;Data;Energy Metabolism;Engineering;Ensure;Enzymes;Equilibrium;Functional disorder;gain of function;Generations;Genetic;Glutamates;Glutaminase;Glutamine;Glutathione;hallmarks of aging;Homeostasis;Impairment;improved;In Vitro;Incubated;insulin regulation;Islets of Langerhans;Isocitrate Dehydrogenase;Isocitrates;knock-down;Label;Lead;Literature;Mammalian Cell;Measures;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;metabolomics;Methods;Mitochondria;mitochondrial dysfunction;Mus;muscle aging;muscle progenitor cell;muscle regeneration;Muscle satellite cell;myogenesis;NADP;novel;Nucleotides;old mice;overexpression;Oxidation-Reduction;Oxidative Stress;pancreatic juice;Pathway interactions;prevent;Production;programs;Proliferating;Proteins;Regenerative capacity;regenerative therapy;Rejuvenation;Research;resilience;restoration;Role;Skeletal Muscle;small molecule inhibitor;stable isotope;stem cell aging;stem cell exhaustion;stem cell function;stem cell proliferation;stem cells;Techniques;Testing;therapeutic target;tissue regeneration;Tissues;Transplantation;Viral;Virus

PROJECT_TITLE: Glutamine-driven "bidirectional" metabolism regulates muscle stem cell function


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Conditions affecting the bladder such as urinary tract infections (UTIs) become more common with aging and can have a severe impact on health span and quality of life, especially among postmenopausal women. Our research aims to uncover how aging predisposes the bladder to UTIs by examining proteostasis and ribosomal and endoplasmic reticulum dynamics. Completion of this work will establish a new platform for new treatments, focusing on drugs that target aging-related bladder changes.

PI_NAMEs: MILLS, JASON C;MYSOREKAR, INDIRA U (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age;age related changes;aged;Aging;aging related;Binding Proteins;biological adaptation to stress;Biological Assay;Bladder;Bladder Tissue;cell age;Cell Aging;Cell Physiology;Cells;Chronic;Collaborations;Complement;cost;Coupled;Cycloheximide;Data;Disease;DNA Damage;Drug Targeting;Elderly;Endoplasmic Reticulum;endoplasmic reticulum stress;Epithelium;epithelium regeneration;experimental study;Foundations;Frequencies;Genes;Genome Stability;glycosylation;Golgi Apparatus;healthspan;Heat shock proteins;Histologic;Homeostasis;Human;Immunofluorescence Immunologic;Incontinence;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;Intervention;Investigation;Label;Lysosomes;Maintenance;Measures;Mediator;Membrane Proteins;Metabolic;Mitochondria;Modeling;Modification;Molecular;Mus;Natural regeneration;new therapeutic target;novel;novel therapeutics;old mice;Organ;Organoids;Oxidation-Reduction;Oxidative Stress;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phenocopy;Phenotype;Play;Post-Translational Protein Processing;Postmenopause;prevent;pro-aging;Proteins;proteostasis;proteostasis loss;Quality Control;Quality of life;Quantitative Reverse Transcriptase PCR;recurrent infection;Regenerative capacity;Research;response;Ribosomes;Role;Rough endoplasmic reticulum;secretory protein;senescence;Senotherapeutic;Stress;stressor;System;tauroursodeoxycholic acid;Testing;Time;tissue regeneration;trafficking;Translating;Translational Repression;Translational Research;Translations;Tunicamycin;Urinary tract;Urinary tract infection;Uropathogenic E. coli;Urothelial Cell;Urothelium;Western Blotting;Woman;Work

PROJECT_TITLE: Cellular and molecular mechanisms governing bladder aging.

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Aging;Digestive Diseases;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Project Narrative Stem cells play critical roles in maintaining the lifespan of key tissue and healthspan of organisms. Here we will study a protein that plays a critical role in intestinal stem cells, and hope to gain insight into how it maintains gut function in aging adults. Its functional properties suggest it may acts a hub to coordinate the function of other critical pathways.

PI_NAMEs: MOBERG, KENNETH H (contact)

PROJECT_TERMS: Adhesions;Adhesives;Adolescent;Adult;adult stem cell;Affect;Aging;Alleles;Architecture;Basement membrane;Behavior;Binding;blastema;Calibration;cell behavior;Cell Count;Cell Cycle;cell dedifferentiation;Cell Differentiation process;cell injury;cell type;Cells;Colon;Complex;Critical Pathways;Cues;Cytoskeleton;Data;Daughter;daughter cell;Development;Disease;domain mapping;Drosophila genus;Drosophila melanogaster;Dysplasia;Ensure;Enterocytes;Epidermal Growth Factor Receptor;Exposure to;F-Actin;Focal Adhesions;Genetic Epistasis;Genetic Transcription;Goals;Growth;Guanosine Triphosphate Phosphohydrolases;gut homeostasis;Health;healthspan;Homeostasis;Homologous Gene;Human;Infection;Ingestion;inhibitor;Injury;Insecta;insertion/deletion mutation;insight;Integrins;intestinal epithelium;intestinal homeostasis;Intestines;Lactobacillus brevis;Licensing;life span;Link;Lysosomes;Maps;Mitogens;Mitosis;Modeling;Molecular;monolayer;mutant;Mutation;notch protein;Organ;Organism;Output;pathogenic microbe;Pathway interactions;Pattern;Phenotype;Phosphatidylinositols;Phospholipids;Phosphorylation;Phosphotransferases;platelet protein P47;Play;prevent;Process;Property;Proteins;repaired;response;rho;rho GTP-Binding Proteins;RNA Interference;Role;S-Phase Fraction;Secretory Cell;Severities;Signal Transduction;stem cell division;stem cell proliferation;stem cells;System;Testing;tissue regeneration;Tissues;tool;Toxin;transcriptome;transgene expression;Transgenes;Work

PROJECT_TITLE: Control of Drosophila intestinal homeostasis by RhoGap15b

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: INDIANAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: RELEVANCE TO PUBLIC HEALTH Dementia is predicted to affect more than 50 million people by the year 2050 and is a leading cause of death. However, there is no cure and more than 400 clinical trials have not proven successful. We believe that immune signaling in the brain causes chronic brain inflammation; therefore, modulation of this signaling would be a viable strategy to prevent neuronal loss.

PI_NAMEs: TERRITO, PAUL RICHARD (contact)

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: Abeta clearance;Ablation;Adenosine;Adult;Affect;Affinity;Age;Alzheimer's disease related dementia;Amyloid;antagonist;APP-PS1;Astrocytes;base;Behavior;Biochemical;Biological Assay;Blood;Brain;Brain region;Caspase;CAST/EiJ Mouse;Cause of Death;Cell Death;Cell membrane;Cell Surface Receptors;Cells;Chronic;Clinical Trials;Cognitive deficits;cohort;Communication;Coupled;cytokine;Data;Dementia;density;Dose;Down-Regulation;druggable target;Encephalitis;Environmental Risk Factor;Exposure to;extracellular;Functional disorder;Genetic;Genetic Transcription;Health;Hippocampus;Homing;Human;human disease;IL18 gene;Immune signaling;immunopathology;Impaired cognition;improved;Inflammation;Inflammatory;Injury;Interleukin-1 beta;Ion Channel Gating;Ions;Knock-out;Ligands;loss of function;loss of function mutation;Measures;Membrane Proteins;Methodology;Microglia;Modeling;Molecular Analysis;mouse model;Mouse Strains;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuroinflammation;neuron loss;Neurons;NF-kappa B;Nitrogen Oxides;novel;Oligodendroglia;P2X-receptor;Pathway interactions;Persons;PET/CT scan;Phagocytosis;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacologic Substance;Physical condensation;Play;pre-clinical;preservation;prevent;Prevention;Process;Proliferating;protein expression;Proteins;Public Health;Purinoceptor;receptor;Receptor Signaling;recruit;response;Role;Short-Term Memory;Signal Transduction;Site;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Superoxides;Synapses;Testing;Tissues;Titrations;tool;tripolyphosphate;Up-Regulation;Work;X-Ray Computed Tomography

PROJECT_TITLE: Targeting P2RX7 Signaling as a Treatment for ADRD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Q(55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Public Health Relevance Statement/Narrative Inflammation contributes to the pathology of Alzheimer's disease and frontotemporal disorder and represents a potential therapeutic target. The findings from this study will help understand how Alzheimer's disease and frontotemporal disorder resemble and differ from one another in the immune response that might point to shared and disease-specific inflammation-based treatment options.

PI_NAMEs: FARIDAR, ALIREZA  (contact);TOLEDO ATUCHA, JUAN B;YUN, KYUSON

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Address;Affect;Age;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid;Apolipoprotein E;Area;Astrocytes;Automobile Driving;Biological Markers;Blood;Brain;Brain region;brain tissue;C9ORF72;CCL11 gene;CCL2 gene;Cell Therapy;cell type;Cells;Characteristics;chemokine;Chronic;Clinical;cohort;Collaborations;CSF1 gene;CSF2 gene;CXCL11 gene;CXCL9 gene;cytokine;Data Analyses;Disease;Disease Progression;Doctor of Philosophy;experience;Gender;Genes;Genetic;genetic risk factor;genetic variant;Goals;IL17C gene;IL18 gene;Immune;Immune response;Immune system;Impaired cognition;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;Intervention;Knowledge;Microglia;Molecular;Molecular Immunology;multiple omics;Mutation;Nerve Degeneration;neural;Neurodegenerative Disorders;Neuroglia;neuroimaging;neuron loss;neuropathology;new therapeutic target;novel;Onset of illness;Outcome;Pathologic;Pathology;Pathway interactions;Patients;Peripheral;Pilot Projects;Proteomics;public health relevance;Regulatory T-Lymphocyte;Reporting;Research;Research Personnel;response;restoration;Sample Size;Sampling;Serum;Sex Differences;sexual dimorphism;Signal Transduction;single cell analysis;single-cell RNA sequencing;Stromal Cell-Derived Factor 1;tau Proteins;Testing;Therapeutic;therapeutic target;TNF gene;TNFSF10 gene;transcriptomics

PROJECT_TITLE: Multi-omic integrative analysis of shared and distinct inflammation networks across neurodegenerative disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Z(55)]