NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: POTOMAC

ORG_NAME: CREATIVE BIO-PEPTIDES, INC.

PHR: 8. Project Narrative There is strong evidence of co-morbid pathologies caused by Aβ, tau and α-synuclein in Alzheimer’s Disease Related Dementias (ADRD) that account for up to 25% of all dementias in patients older than 65 years. Cognitive impairment is closely associated with synapse loss, which occurs significantly prior to neuronal loss, suggesting that synaptic dysfunction is the key treatment target and that ultimately synapse loss by multiple toxic oligomers must be stopped. Creative Bio-Peptides is developing the oral chemokine antagonist peptide RAP-103 to prevent or reverse early synapse loss and cognitive decline in mixed etiology dementias like ADRDs, and will determine synapse density PET imaging and histochemical methods in an animal model of ADRD.

PI_NAMEs: RUFF, MICHAEL R (contact)

PROJECT_TERMS: abeta oligomer;Age;age related;alpha synuclein;Alzheimer's disease related dementia;Amyloid beta-Protein;Animal Model;Animals;antagonist;Antibodies;Autopsy;basal forebrain;Binding;Biological Markers;Brain;Brain Injuries;brain tissue;CCR5 gene;cerebral atrophy;chemokine;chemokine receptor;clinical phenotype;Cognition;cognitive benefits;Cognitive deficits;cognitive function;comorbidity;comparison control;Complex;Creativeness;Dementia;density;Development;Disease;Dose;Etiology;Euthanasia;experience;frontal lobe;Frontotemporal Dementia;Functional disorder;Harvest;Hippocampus;Human;human old age (65+);Impaired cognition;in vivo;interest;Lewy Body Dementia;Measures;Mediating;Membrane;Memory Loss;Methods;Microtubules;mixed dementia;Modeling;Mus;Mutation;Natural regeneration;Nerve Degeneration;Neurofibrillary Tangles;neuroinflammation;neuron loss;Neurons;novel;older patient;Oral;overexpression;Pathology;Patients;Peptides;Phase;phosphoneuroprotein 14;Pilot Projects;Positron-Emission Tomography;Presynaptic Terminals;prevent;protective effect;Proteins;PrP;PrPC Proteins;quantitative imaging;receptor;Research;response;Rodent;Structure;Surface;Synapses;synaptic function;Synaptic Vesicles;synaptogenesis;Synaptophysin;synuclein;System;tau aggregation;tau Proteins;Tauopathies;Testing;Tracer;treatment duration;Vertebral column;Work

PROJECT_TITLE: PET Imaging to Evaluate a Novel Chemokine Antagonist to Protect Synapses in ADRD


ADMINISTERING_IC: HG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE STATEMENT Our innovative bioinformatics platform uses long reads plus short reads to provide an unparalleled opportunity to study the expressions and functions of repetitive genes and gene isoforms, which is important yet challenging “dark matter” in human stem cell transcriptome as well as the corresponding differentiations to different lineages. In addition, our sophisticated platform will provide a set of robust and handy tools to fully analyze long-read transcriptome data, such that this cutting-edge technology can be affordable and feasible in biomedical research laboratories of all sizes. The analyses of the expressions and functions of repetitive genes and gene isoforms at human stem cells and differentiations provide a solid foundation for precision medicine.

PI_NAMEs: AU, KIN FAI  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Acceleration;Address;Adopted;Alternative Splicing;Anterior;Bioinformatics;Biological;Biology;Biomedical Research;Complex;Computer software;cost;dark matter;Data;data integration;Development;Developmental Biology;differential expression;Differentiated Gene;Embryonic Development;Endoderm;Event;Exons;experimental study;Foundations;gene network;Genes;Genetic;Human;human embryonic stem cell;human stem cells;improved;indexing;innovation;Laboratory Research;Methodology;Methods;Modeling;Names;Nature;next generation sequencing;novel;Pathway Analysis;Pattern;Pilot Projects;pluripotency;pluripotency factor;precision medicine;Prevalence;Primitive foregut structure;Protein Isoforms;public health relevance;Publications;Publishing;rapid technique;Regulation;Repetitive Sequence;Research;Retrotransposon;Role;Sampling;Series;Solid;Spliced Genes;Statistical Models;statistics;stem cell biology;stem cells;Structure;Structure of primordial sex cell;Techniques;Technology;The Jackson Laboratory;tool;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Zebrafish

PROJECT_TITLE: Quantitative and function analysis platform for repetitive genes and gene isoforms in pluripotency regulation and differentiations

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PI_NAMEs: HERSHMAN, DAWN ;TERRY, MARY BETH  (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TITLE: Admin Core


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: ATHENS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: NARRATIVE The GlyGen knowledgebase plans to continue its evolution into an essential resource for glycobiology and related domains through integration, harmonization, and annotation of data describing glycan and glycoconjugate dynamics in health and disease.

PI_NAMEs: MAZUMDER, RAJA ;TIEMEYER, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: 5 year old;Anabolism;base;Binding;Binding Proteins;Biology;Biomedical Research;cell type;Cells;Communities;Complex;complex data;Computer software;Consumption;Coupled;Data;Data Analyses;data communication;data format;data harmonization;data integration;data modeling;data portal;Data Set;data visualization;Databases;design;Development;Discipline;Disease;disease phenotype;Education;Education and Outreach;Educational Curriculum;Educational process of instructing;Ensure;Event;Evolution;experience;Feedback;Funding;Future;Gene Expression;Generations;Genes;Genetic Transcription;Genome;genome resource;Genomics;Glycobiology;Glycoconjugates;Glycoproteins;glycosylation;glycosyltransferase;Growth;Health;Heterogeneity;improved;Individual;International;Intuition;Investigation;Isomerism;Knowledge;knowledgebase;Licensing;Link;lipidomics;Lipids;machine learning algorithm;Malignant Neoplasms;Manuals;Maps;Mediating;meetings;metabolomics;Metadata;MicroRNAs;Mission;Modeling;Mutation;Neurosciences;next generation;novel;outreach;Pathway interactions;Pattern;permissiveness;Persons;Polysaccharides;preference;Procedures;Process;Professional Organizations;Prokaryotic Cells;protein expression;Proteins;Quality Control;Regulatory Pathway;Research Personnel;Resource Informatics;Resources;Science;Site;social media;Societies;specific biomarkers;Specificity;Structure;System;Testing;text searching;Tissues;tool;Training;training opportunity;transcription factor;transcriptome sequencing;transcriptomics;Translations;undergraduate student;Visualization;web portal;webinar

PROJECT_TITLE: GlyGen growth and evolution into a central resource for glycans and glycoconjugates

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Injury - Accidents and Adverse Effects

ORG_CITY: LORETTO

ORG_NAME: APPLIED UNIVERSAL DYNAMICS CORPORATION

ORG_STATE: MN

PHR: Project Narrative Older adults are disproportionately affected by falls. Older adults who have memory loss can forget to wear wireless alert pendants or wristbands that are used in case they fall in their home. Falls among adults 65 and older caused over 34,000 deaths in 2019, making it the leading cause of injury death for that group. Older adult falls cost $50 billion in medical costs annually. In 2019, emergency departments recorded 3.14 million visits for older adults for falls; more than 890,000 of these patients had to be hospitalized. People aged 70 and older constitute 13% of the population, but account for 20% of hospital treated falls and 70% of deaths. A low-cost, unobtrusive system capable of automatically detecting and alerting falls in the homes of older adults living alone or those with mild to moderate cognitive impairment, could help significantly reduce the incidence of delayed assistance after a fall.

PI_NAMEs: GIBSON, PAUL  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: 3-Dimensional;Accident and Emergency department;Adult;Affect;aged;Caregivers;Cessation of life;Classification;Communication Methods;Computer software;cost;Craniocerebral Trauma;Darkness;design;Detection;detection platform;Development;Devices;Electronics;Emergency response;Emergency Situation;Endowment;Engineering;Evaluation;experience;falls;Floor;forgetting;Goals;Healthcare;healthy aging;Hip Fractures;Home;Hospitalization;Hospitals;human old age (65+);human study;Image;Impaired cognition;Incidence;Injury;innovation;Internet;Lead;Learning;Life Expectancy;Light;Machine Learning;machine learning algorithm;Measures;Medical Care Costs;Memory Loss;mid-career faculty;Minnesota;Monitor;Motion;older adult;Patients;Performance;Persons;Phase;Population;Principal Investigator;Privacy;professor;prototype;Research;research and development;Risk;School Nursing;sensor;Signal Transduction;software development;Stream;Structure;success;System;Technology;Testing;Time;Training;Traumatic Brain Injury;Universities;Validation;Vendor;Visible Radiation;Visit;wearable device;wireless;wireless communication;Work;wristband

PROJECT_TITLE: Using Structured Light Sensing with Machine Learning to Detect Unwitnessed In-Home Falls


NIH_SPENDING_CATS: Aging;Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Pain Research;Patient Safety;Physical Injury - Accidents and Adverse Effects

ORG_CITY: Lowell

ORG_NAME: REVBIO, INC.

ORG_STATE: MA

PHR: Project Narrative Injuries in the upper and lower extremities equate to more than 40% of fragility fractures, resulting from a low energy trauma event (e.g., falls from standing height) which account for 87% of all orthopedic fractures among the elderly. Complication rates from the current standard of care – open reduction with internal fixation (locking plates and screws) – are as high as 36% and can involve the onset of carpal tunnel syndrome, complex regional pain syndrome, tendon irritation and rupture, deep infections, and the need for revision surgery which often can result in difficulty performing the most basic daily tasks, a reduction in quality of life, and even increased mortality. This project will support commercialization of Tetranite®, a novel, regenerative, bone adhesive for the use of extremity fracture fixation by demonstrating its safety and efficacy through pre-clinical research and a first-in- human clinical trial.

PI_NAMEs: HESS, BRIAN  (contact)

PROGRAM_OFFICER_NAME: FOX, JENNIFER THERESA

PROJECT_TERMS: Acceleration;Address;Adhesives;Adverse event;Age;Aging;Anesthesia procedures;Animals;Award;Biological;biomaterial compatibility;bone;bone fracture repair;bone healing;Cadaver;Carpal Tunnel Syndrome;Clinical Investigator;Clinical Research;clinical research site;Clinical Trials;commercialization;Complex Regional Pain Syndromes;Complication;cost;Defect;design verification;Development;Distal;Elderly;Electroplating;Enrollment;Equation;Event;experience;Failure;falls;Fatigue;Filler;first-in-human;Formulation;Fracture;Fracture Fixation;fragility fracture;Funding;Goals;Good Clinical Practice;Grant;Guidelines;healing;Human;image guided;implant design;improved;Incidence;Infection;Injury;Institution;Intervention;irritation;Life;Limb structure;Lower Extremity;Market Research;Metals;Methods;Mission;Modeling;mortality;Multi-Institutional Clinical Trial;National Institute on Aging;novel;Operative Surgical Procedures;Orthopedics;Oryctolagus cuniculus;Outcome Study;patient population;Patients;Performance;Periodicity;Persons;Phase;Population;pre-clinical research;preclinical development;preclinical study;prevent;primary endpoint;Process;product development;programs;Quality of life;radiological imaging;Radius Fractures;Recurrence;regenerative;Regional Anatomy;Reporting;Research;Risk;Rupture;Safety;safety study;sample fixation;Sampling;Second Look Surgery;Sheep;Site;Small Business Innovation Research Grant;Specific qualifier value;standard of care;standing height;Sterility;Sterilization;Surgeon;Syndrome;System;Techniques;Tendon structure;Testing;Training;Trauma;Upper Extremity;usability;Validation;validation studies;Work

PROJECT_TITLE: Commercialization of an Improved Treatment of Extremity Fractures Using a Regenerative Bone Adhesive to Accelerate Bone Healing in Aging Patients


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BOSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Detection of preclinical Alzheimer’s disease (AD) is considered a critical prerequisite for early, effective, and enduring AD treatment. This project will test a novel lens amyloid scanner (Sapphire II) with FDA Breakthrough Device designation that utilizes an amyloid-binding tracer (Aftobetin) and specialized eye scanner to measure β-amyloid (Aβ) in the lens for early detection and longitudinal monitoring of AD. We will test the project hypothesis that elevated lens Aβ burden is predictive of cognitive decline and early, pre-symptomatic (preclinical) AD in the longitudinal Clinical Core cohort at the NIA-funded Boston University Alzheimer’s Disease Research Center.

PI_NAMEs: ALOSCO, MICHAEL ;GOLDSTEIN, LEE E. (contact);MEZ, JESSE BENJAMIN

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: abeta accumulation;Acceleration;Address;Age;aging related disease;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;apolipoprotein E-4;Attention;Autopsy;beta amyloid pathology;Binding;Binding Proteins;Biological Assay;Biological Markers;Blood;Boston;Brain;Brain Pathology;Brain scan;Breakthrough device;Categories;Cause of Death;Cerebrospinal Fluid;Clinical;clinical biomarkers;clinical center;Cognition;cohort;comparative;Consensus;cost effective;cost efficient;Cost of Illness;Couples;Crystalline Lens;Data;Dementia;design;Detection;Development;Devices;Diagnosis;Diagnostic;Diagnostic Equipment;Disease;Disparity population;Down's Syndrome;Drug Combinations;early detection biomarkers;Early Diagnosis;early onset;effective therapy;Evaluation;Eye;Fluorescence Spectroscopy;Funding;genome-wide;Heritability;hippocampal atrophy;Image;Impaired cognition;Impairment;in vivo;indexing;Individual;individual patient;innovation;Investigation;Language;lens;Life;Ligands;Light;Link;Magnetic Resonance Imaging;Measurement;Measures;Memory;Methods;mild cognitive impairment;Monitor;Nerve Degeneration;Neurobehavioral Manifestations;Neurodegenerative Disorders;neurofilament;Neurologic;Neuropsychological Tests;Noise;normal aging;novel;novel marker;novel strategies;Ointments;Ophthalmoscopes;Outcome;Participant;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Phenotype;point of care;Point of Care Technology;polygenic risk score;Positron-Emission Tomography;pre-clinical;Predictive Value;Race;rate of change;Reporting;Research;research clinical testing;risk variant;ROC Curve;Sample Size;Sapphire;Scanning;Sensitivity and Specificity;sex;Signal Transduction;Specificity;Spectrum Analysis;Spinal Puncture;Sum;Symptoms;System;tau Proteins;tau-1;Technology;Testing;Time;Topical application;Tracer;Ultrastructural Pathology;Universities;Validation;β-amyloid burden

PROJECT_TITLE: Validation of Lens Beta-Amyloid as a Novel Biomarker for Early Detection of Alzheimer's Disease at the Boston University Alzheimer's Disease Research


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: RELEVANCE (See instructions): Little is known regarding the neural circuitry responsible for reward seeking behaviors in adolescence.  However, adolescence is characterized by an increased motivation to seek reward and is a time period  where several mental disorders characterized by alterations in motivational processes emerge. The  proposed projects seek to investigate how adolescent and adult brains differentially influence reward  behaviors and the impact of adolescent alcohol drinking on brain function and behavior.

PI_NAMEs: MCCANE, AQILAH MARYAM (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: addiction;Adolescence;Adolescent;adolescent alcohol exposure;Adult;age difference;age related;age related changes;Alcohol dependence;alcohol risk;alcohol use disorder;alcohol use initiation;Alcohols;Behavior;Behavior Control;Behavioral;behavioral response;Brain;clinically relevant;Computer Models;Corpus striatum structure;Data;Development;developmental disease;Disease;Dopamine;dopaminergic neuron;drug of abuse;Electrophysiology (science);Employment;Etiology;Exhibits;experimental study;Extinction;frontal lobe;Functional disorder;Future;Genetic;Goals;Impairment;in vivo;Instruction;Lateral;mature animal;Mental Depression;Mental disorders;Mental Processes;Methods;Modeling;Mood Disorders;motivated behavior;Motivation;motivational processes;neural;neural circuit;neural model;neuronal circuitry;Neurons;neurophysiology;novel;Pathology;Performance;Phase;Physiological;Physiology;Play;Population;predictive modeling;Process;Property;Psychopathology;Rattus;Resistance;response;Rewards;Risk;Role;Schizophrenia;Stimulus;Substance Use Disorder;Sucrose;System;Testing;Time;tool;Training;underage drinking;Work

PROJECT_TITLE: Modeling age-specific computational strategies during reward seeking

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE- OVERVIEW The Indiana University Melvin and Bren Simon Cancer Center is an NCI-designated Cancer Center whose mission is to create an expanding community of researchers and health professionals who conduct outstanding translational research, provide excellence in education, and deliver high quality patient-centered care. We will foster and promote an environment of cultural awareness, diversity, and inclusion as we contribute to the prevention and cure of cancer in Indiana. We recognize social injustices and discrimination exist, and we further our mission by embracing the rich perspectives and experiences that arise from racial, ethnic, socioeconomic, sexual, gender, and religious diversity within our community.

PI_NAMEs: LEE, KELVIN P. (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: anti-cancer research;Antineoplastic Agents;Awareness;Basic Science;Biological;Biology;Biometry;Black Populations;Black race;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer research center director;cancer risk;Catchment Area;Characteristics;Clinical Cancer Center;clinical care;Clinical Pathways;Clinical Sciences;Code;Colorectal Cancer;Communities;community engaged research;community engagement;Community Outreach;Comprehensive Cancer Center;County;Data;Death Rate;Dedications;Development;Discrimination;Disease;Doctor of Philosophy;drug development;drug discovery;early phase clinical trial;Education;Environment;equity, diversity, and inclusion;Ethics;Ethnic Origin;experience;Fostering;Foundations;Funding;Gender;Generations;Grant;Growth;Guidelines;Health;health equity;Health Professional;Healthcare Systems;Hispanic Populations;Human Papilloma Virus Vaccination;Immunotherapy;Incidence;Indiana;Informatics;innovation;Institution;interdisciplinary collaboration;investigator-initiated trial;Journals;Leadership;Lifting;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;Medicine;member;Mission;mortality;multidisciplinary;Names;National Comprehensive Cancer Network;NCI-Designated Cancer Center;next generation;Non-Hodgkin's Lymphoma;Not Hispanic or Latino;Nursing Faculty;Obesity;Oncology;Ovarian;Patient Care;Patient-Centered Care;Patients;peer;Peer Review;Policies;Population;population health;Population Sciences;Prevention;Productivity;programs;Prostate;Publications;Race;Recording of previous events;recruit;Religion;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Risk Factors;Rural;rural dwellers;Science;Services;Smoking;social;social determinants;Social Sciences;Societies;socioeconomics;Standardization;Teenagers;Therapeutic;Training;Translational Research;Translations;Universities;Uterine Cancer;Vision

PROJECT_TITLE: Indiana University Melvin and Bren Simon Comprehensive Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Infectious Diseases;Neurosciences;Vector-Borne Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PI_NAMEs: PERRY, MICHAEL WILLIAM (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Address;Adult;Aedes;Amaze;Animal Behavior;Animals;Back;Behavior;behavior influence;Botanicals;Brain;Butterflies;Candidate Disease Gene;Cataloging;cell fate specification;cell type;Characteristics;citizen science;Collaborations;Color Visions;Communities;comparative;Complex;compound eye;CRISPR/Cas technology;Crustacea;Culicidae;Data;Detection;Development;Developmental Biology;Developmental Process;Drosophila genus;Education;Educational Activities;Eels;Environment;Evolution;Eye;Gene Expression;gene function;gene interaction;gene network;gene regulatory network;Genes;Genetic;Genome;genome editing;genome sequencing;Genomics;Goals;High School Student;improved;Insecta;Instruction;interest;member;Middle School Student;Modeling;Modification;Monitor;Morphology;mosaic;Musca domestica;Mutation;Nervous System;neural;Neurons;novel;Nucleic Acid Regulatory Sequences;outreach;Paint;Pattern;Photoreceptors;Process;Research;Resources;response;Retina;retinal neuron;Schools;Science;Scientist;Shapes;Signal Pathway;single cell sequencing;Specific qualifier value;Structure;Students;Study models;Surface;Surveys;System;Techniques;Testing;Time;Tissues;tool;tool development;trait;transcription factor;undergraduate student;Underrepresented Populations;Vision;Visit;Visual;Visual System;Walking;Water;Work;Yellow Fever

PROJECT_TITLE: EDGE CMT: Neural cell type evolution in insect retinas

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-P (J3)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Human Genome;Immunotherapy;Lupus;Prevention;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibrosing inflammatory disease that frequently presents with an allergic predisposition driven by a TH2 response. We have identified two genetic variants in familial IgG4-RD. Here we propose to develop immunological models how these variants cause loss of tolerance and TH2 polarization that may be relevant for non-familial IgG4-RD and other polygenic autoimmune diseases.

PI_NAMEs: GORONZY, JORG J (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Adoptive Transfer;Affect;Affinity;Allergic;allergic airway disease;allergic airway inflammation;Amphiregulin;Antibodies;Atopic Dermatitis;atopy;Autoimmune;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;Biological;Biological Markers;CD4 Positive T Lymphocytes;Cells;cellular transduction;Cleavage Under Targets and Release Using Nuclease;Code;Complex;Data;Daughter;Disease;disease model;DNA Binding;Eosinophilia;epigenome;Exhibits;exome sequencing;Family;Family member;Fathers;Fibrosis;FYN gene;gain of function;gain of function mutation;Gene Family;Genes;Genetic;Genetic Predisposition to Disease;Genetic Transcription;genetic variant;genome wide association study;Haplotypes;Hematopoietic;Human;Hypersensitivity;IgE;IgG4;IL4 gene;IL5 gene;Immune;Immunity;Immunization;immunodeficiency;Immunoglobulins;Immunological Models;In Vitro;in vivo;Inflammation;Inflammatory;insight;Interleukin-13;lenalidomide;loss of function;loss of function mutation;Major salivary gland structure;member;Modeling;Monogenic autoimmune disease;Mothers;Mus;Mutate;Mutation;Ocular orbit;Ovalbumin;Pancreas;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Penetrance;Peripheral;pharmacologic;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Polygenic Traits;Predisposition;prevent;Process;Production;Proteome;Proteomics;PTPN22 gene;PTPRC gene;Reporting;response;Retroperitoneal Space;Risk;Role;screening;Serum;Signal Pathway;Signal Transduction;soft tissue;systemic autoimmune disease;Systemic Lupus Erythematosus;T-Cell Activation;T-Lymphocyte;TCR Activation;Th2 Cells;Therapeutic;Tissues;tool;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;ubiquitin-protein ligase;Variant;Zinc Fingers

PROJECT_TITLE: Mechanisms of genetic variants in TH2 autoimmunity

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BIRMINGHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Chronic exposure to drugs such as psychostimulants produces long-lasting molecular and functional changes in the brain, which in vulnerable individuals result in behavioral changes that further predispose them to loss of control in their drug use and progression of Substance Use Disorder (SUD). These drugs produce remarkably similar behavioral outputs and act on similar molecular targets in the nervous system (brain equivalent) of the simple yet powerful model organism Caenorhabditis elegans. In this proposal, we leverage the capabilities for high-resolution, large-scale, and rapid genetic analysis of the entire nervous system in C. elegans to identify candidate regulators of long-lasting drug-induced changes and open up novel avenues of therapeutic interventions for SUD.

PI_NAMEs: SUN, HAOSHENG  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Acute;Atlases;Behavioral;Biological;Brain;Caenorhabditis elegans;candidate identification;Chromatin;Chronic;Cocaine;cocaine exposure;Disease;Drug Exposure;Drug usage;effective therapy;Epigenetic Process;Exposure to;Future;Genetic;genetic analysis;Genomics;high throughput screening;in vivo;Investigation;Knowledge;Microscopy;model organism;Modeling;Molecular;Molecular Target;Nematoda;Nervous System;Neurons;novel;Output;Pharmaceutical Preparations;Predisposition;psychostimulant;Resolution;response;Role;Specificity;stimulant exposure;Substance Use Disorder;Therapeutic;Therapeutic Intervention;transcriptome;Vulnerable Populations

PROJECT_TITLE: High-throughput identification and characterization of conserved regulators of drug-induced plasticity using single-neuron resolution atlases of the complete Caenorhabditis elegans nervous system

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 IXR-N (M1)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_DEPT: NEUROSURGERY

PHR: Narrative The Training Program in Tumor Microenvironment (TPTM) is an interdisciplinary program whose central goal is to train exceptional junior investigators to address fundamental biological problems related to human cancer. The TPTM trains both predoctoral and postdoctoral scholars providing research opportunities focusing on a wide choice of topics in the field of tumor microenvironment as it relates to cancer biology and therapeutic response. Through selective appointments, didactic coursework, and transdisciplinary programmatic activities, the TPTM is creating a diverse pipeline of young investigators who will have a lasting impact on cancer research.

PI_NAMEs: CASTRO, MARIA G (contact);DIFEO, ANALISA VIRGINIA

PROGRAM_OFFICER_NAME: LIM, SUSAN E

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Pediatric

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Allergic and immunologic disorders continue to rise in prevalence and currently account for many of the most common and important diseases affecting infants and children. The need for cutting edge basic, translational, and clinical research in pediatric allergy and immunology is therefore greater than ever, although exceedingly few programs are equipped to provide the training needed to conduct this research. Support for programs like ours, that are not only equipped to provide the best possible training but also have a documented record of success in producing the leaders in pediatric allergy and immunology, is therefore more important than ever.

PI_NAMEs: WOOD, ROBERT A (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TITLE: Research Training in Pediatric Allergy and Immunology

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 JTS-I (M1)]


ORG_CITY: HANOVER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: The HMI Training Program seeks to provide research training and professional development opportunities to talented and highly motivated students that have been recruited into our Trainers’ laboratories. Our Trainees gain clinical insights through attendance of Clinical Microbiology Rounds, learn programming and bioinformatics approaches, host a speaker and lead a journal club in an area of interest among other activities and opportunities. The Director and Associate Director are supported by a Professional Development Subcommittee and strong Internal and External Advisory Committees as they provide a program that will support Trainees as they launch the successful pursuit of biomedical careers that will positively impact the health of our citizens and those around the world.

PI_NAMEs: HOGAN, DEBORAH A (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: host-microbe interactions

PROJECT_TITLE: Host-Microbe Interactions

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ORG_CITY: PITTSBURGH

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Surgical oncologists have a long and important history of contributions to the field of oncology as translational scientists. However, surgeons are increasingly being underrepresented in translational research and there has been a call to address this shortage. This training program is uniquely designed to prepare surgeons for a career in translational science to maximize their ability to make meaningful contributions to society though advancing our understanding and treatment of cancer.

PI_NAMEs: KAMMULA, UDAI S (contact)

PROJECT_TERMS: Biological Response Modifier Therapy;Malignant Neoplasms;Postdoctoral Fellow;Research Training

PROJECT_TITLE: Postdoctoral Research Training in Biotherapy of Cancer


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

PHR: PROJECT NARRATIVE Pulmonary arterial hypertension (PAH) is a highly morbid disease that leads to right ventricular failure and mortality. Pulmonary artery smooth muscle cells in pre-clinical models of disease have been shown to resist programmed cell death, a critical step in the development and maintenance of PAH. I will study the role of the proteins aquaporin 1 and caspase-3 in promoting smooth muscle cell resistance to death.

PI_NAMEs: NIEDERMEYER, SHANNON  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Address;Animal Model;Apoptosis;Apoptotic;AQP1 gene;Automobile Driving;Binding Proteins;Biological Assay;Biotin;Biotinylation;Blood Vessels;cancer type;career;CASP3 gene;Caspase;Cell Death;Cell Membrane Proteins;Cell Nucleus;Cell Physiology;Cell Separation;Cells;Cessation of life;Co-Immunoprecipitations;Confocal Microscopy;Cytosol;Data;design;Development;Diagnosis;Disease;disease model;Disease Progression;Educational process of instructing;experimental study;extracellular;Foundations;Fractionation;Funding;Future;gain of function;Goals;Hypertrophy;Immunofluorescence Microscopy;Immunoprecipitation;in silico;In Situ Nick-End Labeling;Individual;insight;interest;Ischemia;K-Series Research Career Programs;knock-down;Laboratories;Lesion;Ligase;Link;loss of function;Lung;Maintenance;Malignant - descriptor;Malignant Neoplasms;Measures;Medial;Membrane;Membrane Proteins;migration;Modeling;Molecular;mortality;new therapeutic target;Normal Cell;novel;Nuclear;Outcome Measure;overexpression;Oxidants;Pathway interactions;Patient Care;Peptide Hydrolases;Play;Pre-Clinical Model;prevent;Proliferating;protein expression;protein protein interaction;Proteins;Proteomics;pulmonary arterial hypertension;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular cell proliferation;Rattus;Regulation;Resistance;Resistant Hypertension;response;right ventricular failure;Role;Scientist;Site;Site-Directed Mutagenesis;skills;Smooth Muscle Myocytes;Stains;Stimulus;System;Tail;Techniques;Testing;Toxin;Training;Water;water channel;Work

PROJECT_TITLE: Mechanisms Driving Apoptosis Resistance in Pulmonary Hypertension


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: OVERALL COMPONENT NARRATIVE The TIME-AD Program Project brings together multiple large, diverse data sets and new methods to establish whether interventions targeting alcohol, depression or depression treatment, treatment of vision or hearing impairments, or social isolation could reduce AD/ADRD incidence or AD/ADRD inequities. By systematically comparing results from different study designs and populations we will provide more rigorous evidence than previously possible and help fill a priority research gap in the National Plan to Address Alzheimer’s Disease. The overall benefit of the proposed work is enhanced by synergies across shared cores, which provide expertise in the multiple data sources, analytic methods, health equity, and evidence dissemination and integration of evidence on four major, modifiable, risk factor categories.

PI_NAMEs: GILSANZ, PAOLA ;GLYMOUR, MEDELLENA MARIA (contact);TORRES, JACQUELINE MARIE

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Acceleration;Address;Alcohol consumption;alcohol effect;Alcohols;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;analytical method;Asian;Behavioral;biobank;Black race;California;care systems;Categories;chronic pain;Clinical;clinical care;Code;Cognition;Cognitive;Cognitive aging;cohort;Data;data access;Data Analyses;data management;Data Set;Data Sources;Databases;dementia risk;Disparity;disparity reduction;diverse data;Electronic Health Record;Ensure;Equity;Ethnic Origin;Etiology;Fostering;frontier;gender difference;Genetic;genetic risk factor;health equity;Health Priorities;hearing impairment;Heterogeneity;improved;improved outcome;Incidence;Inequity;innovation;interest;Intervention;Knowledge;Latino;Life Cycle Stages;Long-Term Effects;Measurement;Measures;Mental Depression;Methodology;Methods;Modeling;modifiable risk;multiple data sources;multiple datasets;Observational Study;Outcome;Participant;Policies;Population;Population Heterogeneity;prevent;Prevention;Prevention Research;Prevention strategy;programs;public health priorities;Quasi-experiment;Race;randomized trial;Randomized, Controlled Trials;Reporting;Reproducibility;Research;Research Design;Research Methodology;Research Priority;Research Project Summaries;Resource Sharing;Risk Factors;Role;Sampling;Selection Bias;social;Social isolation;Socioeconomic Status;study population;Surveys;synergism;tool;trial design;Uncertainty;Variant;Visual impairment;Work

PROJECT_TITLE: Improving causal inference in Alzheimer's Disease prevention research on modifiable risk factors: the Triangulation of Innovative Methods to EndAD (TIME-AD) project

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-P (M4)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Prevention

PI_NAMEs: GLYMOUR, MEDELLENA MARIA (contact)

PROJECT_TERMS: Address;Agreement;Alcohol consumption;Alzheimer disease prevention;Alzheimer's disease related dementia;analytical method;Authorship;Behavioral;Benchmarking;Budgets;career;Cell Nucleus;Charge;Code;Cognition;cognitive neuroscience;Collaborations;Communication;Communities;Complex;Computers;dashboard;Data;Data Set;Data Sources;Decision Making;Dedications;Development;Doctor of Philosophy;Documentation;Effectiveness;Ensure;Equity;experience;Feedback;Fostering;Future;Genetic;health equity;Health system;hearing impairment;human subject;improved;Incidence;Information Dissemination;Infrastructure;innovation;Institution;interest;Lead;Leadership;meetings;member;Mental Depression;Mentors;Methodology;Methods;modifiable risk;Monitor;multiple datasets;operation;Peer Review;Play;Policies;Preparation;Prevention;Prevention Research;Professional Organizations;programs;Progress Reports;Protocols documentation;Publications;recruit;Reporting;Reproducibility;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk Factors;Scientist;sharing platform;Social isolation;Structure;success;symposium;Training;Translations;Update;Visual impairment;Work

PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: HUANG, CHIUNG-YU  (contact)

PROJECT_TERMS: Adopted;Adoption;Aging;Alcohol consumption;Alzheimer disease prevention;Alzheimer's disease related dementia;biobank;California;causal model;Clinical Data;Code;Cognition;Cognitive;cohort;Communities;Complex;Data;Data Set;Data Sources;Dementia;design;Development;diverse data;Electronic Health Record;Ensure;Equity;Ethnic Origin;Etiology;Fostering;functional outcomes;Genetic;geographic disparity;Goals;Health;Health and Retirement Study;hearing impairment;Heart;heterogenous data;improved;Incidence;Inequality;Inequity;innovation;insight;instrument;intervention effect;Lead;Longitudinal Studies;Measurement;Measures;Mendelian randomization;Mental Depression;Methodology;Methods;modifiable risk;multiple data sources;multiple datasets;novel strategies;Observational Study;Outcome;Policies;Population;Population Attributable Risks;Population Heterogeneity;Prevention;Prevention Research;Prevention strategy;Process;programs;Race;racial disparity;Randomized, Controlled Trials;Reporting;Reproducibility;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Risk Factors;risk selection;Sampling;Schedule;Social isolation;socioeconomics;Statistical Methods;Stroke;Subgroup;success;Time;time interval;trend;Variant;Visual impairment;Work;Youth

PROJECT_TITLE: Core B: Analytics Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

PI_NAMEs: GILSANZ, PAOLA  (contact)

PROJECT_TERMS: Accountability;Advocate;Affect;African American population;aging brain;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Automobile Driving;Biological Factors;brain health;Caring;caucasian American;Clinical;Collaborations;Communication;Communities;Community Health;community organizations;Complex;Data;Data Analyses;data cleaning;Data Sources;Dementia;dementia risk;Diagnosis;Dimensions;Disease;Disease Progression;Economics;Ensure;Epidemiologist;Equity;Ethnic Origin;Etiology;experience;Family;Gender;General Population;Goals;Health;health equity;Health system;Healthcare;improved;Individual;Inequity;Infrastructure;innovation;Intervention;Lesbian Gay Bisexual Transgender Queer;Link;marginalized population;meetings;Methods;modifiable risk;Onset of illness;Pathway interactions;Persons;Policy Maker;population health;Population Heterogeneity;Populations at Risk;Prevalence;Prevention;Prevention program;Prevention Research;Prevention strategy;Process;programs;protective factors;Provider;Psychological Factors;Race;Research;Research Personnel;Research Project Grants;Resources;Risk;Risk Factors;Sampling;Schedule;Science;Scientist;sex;Sex Orientation;social;social factors;Socioeconomic Status;Source;Specialist;Structure;Subgroup;White Women;Work

PROJECT_TITLE: Equity and Dissemination Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: CASALETTO, KAITLIN B (contact)

PROJECT_TERMS: Address;Affect;Alcohol consumption;Alzheimer disease prevention;Alzheimer's disease related dementia;anti-depressive agents;anti-racism;Biological Process;Categories;cerebrovascular;Classification;Clinical;clinical diagnosis;clinical diagnostics;Code;Cognition;Cognitive;cognitive change;cognitive reserve;cognitive testing;Cohort Studies;Complex;Consult;Data;Data Analyses;data cleaning;data harmonization;data integration;data management;Data Set;Data Sources;Databases;Dementia;Diagnosis;Disparate;Documentation;Ensure;Epidemiologic Methods;Epidemiologist;Equity;ethnic identity;Etiology;Genetic;Grouping;hearing impairment;Heart;improved;innovation;Judgment;Measurement;Measures;Mediating;Mediator;Mental Depression;Methodology;Methods;Modeling;Modernization;modifiable risk;multiple data sources;neurobehavioral;Neuropsychology;Outcome;Outcome Assessment;Pathologic;Pathology;Persons;Pharmaceutical Preparations;Policies;Positioning Attribute;Prevention;Prevention Research;Race;Reproducibility;Research;Research Personnel;Research Project Grants;research study;Resource Sharing;Risk;Risk Factors;Science;Secure;Severities;Social isolation;Statistical Models;Stream;Structure;success;Surveys;synergism;Time;trial design;Visit;Visual impairment;Work

PROJECT_TITLE: Core D: Cognition, Exposure, and Covariates (CEC) Data Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Prevention;Social Determinants of Health

PROJECT_TERMS: Accountability;Address;Adoption;Adult;Age;Alcohol consumption;Alcohols;Alleles;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;analytical method;anti-depressive agents;Code;cohort;Collaborations;Complement;Conceptions;Consult;Data;data access;Disparity;Documentation;Dose;Economics;Ensure;Epidemiology;Equity;Ethnic Population;Etiology;Evaluation;evaluation/testing;Exclusion;Fertilization;flexibility;Formularies;Fostering;Genetic;Genetic Risk;genetic variant;Genotype;Goals;health care delivery;health equity;health equity promotion;Health system;hearing impairment;improved;Incidence;innovation;Institution;instrument;Light;Literature;Measures;member;Mendelian randomization;Mental Depression;Methodology;Methods;minimum drinking age;Modeling;modifiable risk;Modification;Motivation;multiple data sources;Outcome;Pathway interactions;Performance;Persons;Pharmaceutical Preparations;Pharmacy facility;Policies;Population Heterogeneity;prevent;Prevention;Prevention Research;Primary Care;Protocols documentation;Quasi-experiment;racial population;Random Allocation;Relaxation;Reproducibility;Research;Research Design;Research Personnel;Resource Sharing;response;Risk Factors;Sampling;screening, brief intervention, referral, and treatment;Sensory impairment;social;Social Environment;Social isolation;Source;Specific qualifier value;Statistical Methods;Statistical Models;Subgroup;System;Taxes;Testing;Time Factors;Treatment Protocols;Validation;Variant;Visual impairment;Work

PROJECT_TITLE: Core E: Genetic and Policy Data Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Substance Misuse

PROJECT_TERMS: Adopted;Adult;Adverse effects;Affect;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol intervention;alcohol misuse;alcohol risk;alcohol use disorder;Alcohols;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Beer;binge drinking;biobank;California;cardiometabolism;Cardiovascular system;Characteristics;Clinical;clinical care;Clinical Treatment;Cognition;Cognitive;cognitive change;cohort;comorbidity;Consumption;Data;Data Set;Data Sources;Databases;Dementia;dementia risk;design;disorder risk;Disparity;diverse data;Dose;drinking;Education;Electronic Health Record;ethnic identity;Ethnic Origin;Etiology;Evaluation;flexibility;Frequencies;Gender;Genetic;Genetic Risk;Genotype;Heavy Drinking;Heterogeneity;improved;Incidence;Individual;Inequality;innovation;insight;Intervention;Learning;Light;Longitudinal cohort;marijuana use;Measurement;Measures;Methodology;Methods;middle age;modifiable risk;national surveillance;older adult;Outcome;Outcome Measure;Pattern;Persons;Pharmaceutical Preparations;Policies;Population;Population Attributable Risks;Prevalence;Prevention;Prevention Research;Race;racial identity;Randomized, Controlled Trials;red wine;reduced alcohol use;Research;Research Design;Resources;response;Rest;Risk;Risk Factors;Role;Sample Size;Sampling;Shapes;social;Social isolation;Social Policies;socioeconomic disparity;Socioeconomic Status;Source;Statistical Methods;surveillance data;Surveys;Uncertainty;Wine;Woman;Work

PROJECT_TITLE: Project 1: Alcohol use and AD/ADRD risk: innovative methods and data for new insights


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Dementia;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Pain Research;Prevention

PROJECT_TERMS: Accounting;Address;Adult;Affect;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;anti-depressive agents;antidepressant effect;Attention;Attenuated;Black Populations;cerebrovascular;Cerebrovascular Disorders;Chronic Care;chronic pain;Cognition;cognitive function;cohort;comorbidity;Data;Data Analyses;Data Set;Data Sources;Databases;Dementia;dementia burden;dementia risk;depressive symptoms;Diabetes Mellitus;disorder risk;Disparity;diverse data;Education;Electronic Health Record;Ethnic Origin;Etiology;Evaluation;experience;follow-up;Gender;genetic information;Goals;health disparity;health equity;Heterogeneity;High Prevalence;high risk;Hispanic Populations;Impaired cognition;improved;Incidence;Individual;Inequality;Inequity;innovation;Joints;Link;Long-Term Effects;marginalized population;Measures;Mental Depression;Methodology;Methods;modifiable risk;Nonpharmacologic Therapy;novel;older adult;Older Population;Outcome;Pattern;Persons;pharmacologic;Pharmacological Treatment;Population;Prevalence;Prevention Research;public health priorities;Race;Randomized, Controlled Trials;Recurrence;recurrent depression;Research Design;Risk;Risk Factors;Role;Science;Severities;Socioeconomic Status;Source;Surveys;Techniques;treatment effect;Treatment Effectiveness;United States National Institutes of Health;Woman

PROJECT_TITLE: Project 2: Depression and chronic pain: Modifiable targets for prevention of AD/ADRD


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Disability Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Neurodegenerative;Neurosciences;Prevention;Rehabilitation;Social Determinants of Health

PI_NAMEs: BRENOWITZ, WILLA DOMINO (contact)

PROJECT_TERMS: Address;Affect;age related;Aging;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;biobank;Blindness;Body Composition;California;cardiovascular risk factor;Cardiovascular system;Cataract Extraction;Clinical;Clinical Trials;Cognitive aging;cognitive testing;comorbidity;Complex;Data;Data Set;Data Sources;dementia burden;dementia risk;Education;Epidemiology;Ethnic Origin;Etiology;follow-up;Gender;Genetic;genetic information;Genetic Risk;genetic variant;Goals;Health;Health and Retirement Study;Healthcare;Hearing;Hearing Aids;hearing impairment;Heterogeneity;high risk;Impaired cognition;Impairment;improved;Incidence;Individual;Inequity;innovation;insight;Intervention;Intervention Trial;large scale data;Link;Longitudinal cohort study;Longitudinal Studies;Measurement;Measures;Mendelian randomization;Methods;Modernization;modifiable risk;Modification;multiple data sources;Nerve Degeneration;older adult;Population;Population Attributable Risks;Population Heterogeneity;Prevalence;Prevention;Prevention Research;Process;programs;Psychosocial Factor;Race;Research Design;Risk Factors;Risk Reduction;Sample Size;Sampling;Selection Bias;Sensory;Sensory impairment;sex;sex variable;social;social factors;social health determinants;Socioeconomic Status;Source;Subgroup;Time;treatment effect;trend;Uncertainty;Vision;Visual impairment;Work

PROJECT_TITLE: Project 3: Prevention and Treatment of Hearing and Vision Impairments for Reducing AD/ADRD risk


PI_NAMEs: TORRES, JACQUELINE MARIE (contact)

PROJECT_TERMS: Accounting;Address;Alzheimer disease prevention;Alzheimer's disease related dementia;Alzheimer's disease risk;Attention;Bereavement;Calibration;cohort;Cohort Studies;Communities;Data;Data Set;Data Sources;dementia risk;Disparity;diverse data;Ethnic Origin;Etiology;evidence base;Exposure to;flexibility;follow-up;Future;Gender;Genetic Risk;Healthcare Systems;Heterogeneity;improved;Incidence;Individual;Inequity;infancy;innovation;Insurance Carriers;Intervention;Intervention Trial;late life;Life;Life Cycle Stages;Link;marginalized population;Measurement;Measures;Methodology;Methods;modifiable risk;multiple data sources;novel;Observational Study;Odds Ratio;older adult;pandemic disease;peer;Population;Population Attributable Risks;population based;Population Group;Prevalence;prevent;Prevention Research;Publishing;Race;racial difference;Reporting;Research;Research Design;Resources;Risk Estimate;Risk Factors;Rural;Sample Size;Science;screening;Sex Differences;Sex Orientation;social;social contact;social engagement;social inclusion;Social isolation;Socioeconomic Status;Source;Subgroup;Telephone;Testing;theories;therapy design;therapy development;Time;United States National Academy of Sciences;urban residence;Variant;Work

PROJECT_TITLE: Project 4: Social isolation as a driver of AD/ADRD incidence and disparities


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative This application requests funds to support the training of six pre-doctoral students per year in the successful Infectious Diseases Across Scales Training Program at Emory University. Thirty-one training faculty from six graduate programs with exceptional strengths in infectious disease research will provide students with training opportunities across a wide range of biological scales, ranging from the immune molecules that dictate interactions between human host cells and pathogens, to the ecosystems in which humans share their pathogens with vectors and other animals. The over-arching goal of this training program is to provide students with the inter-disciplinary and cross-cutting skills and tools to better understand and control infectious disease, and thereby increase healthcare in the United States and beyond.

PI_NAMEs: DE ROODE, JACOBUS  (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Communicable Diseases;Training Programs

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Physical Rehabilitation;Rehabilitation

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: Project Narrative The Rehabilitation Medicine Scientist Training Program (RMSTP) aims to develop physician scientists in rehabilitation. The RMSTP will recruit a diverse group of promising residents and junior faculty in rehabilitation-related specialties to attend an annual Research Career Development Workshop and receive quarterly guidance through small-group teleconferences. RMSTP training is designed to help participants define their area of research interest, find appropriate local mentors, successfully apply for individual career development funding, and transition successfully to independent research careers.

PI_NAMEs: BONINGER, MICHAEL L. (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Acceleration;Acute;Address;Aging;aging population;Area;Benchmarking;career;career development;clinical practice;Collaborations;Committee Members;cost;design;Development;Development Plans;Disabled Persons;Educational workshop;Elements;Ensure;Evaluation;Event;evidence base;experience;Extramural Activities;extreme weather;Faculty;follow-up;Fostering;Funding;Goals;Government;Grant;Grant Review;health data;improved;improved outcome;Individual;innovation;interest;Investments;Junior Physician;K-Series Research Career Programs;Link;Medical center;medical specialties;Mentors;Methods;Military Personnel;Mission;multidisciplinary;National Institute of Child Health and Human Development;Participant;Peer Review;Phase;Physical Medicine;Physicians;Population;Premature Infant;Principal Investigator;Productivity;programs;Recommendation;recruit;rehabilitation research;rehabilitation science;Rehabilitation therapy;Research;Research Peer Review;Research Personnel;Scientific Advances and Accomplishments;Scientist;success;Talents;Teleconferences;Time;Topical application;Training;Training Programs;Translating;Translational Research;Translations;trend;United States National Institutes of Health;videoconference;Work

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative The major goal of this Training Program is to provide an interdisciplinary research and training environment wherein trainees will be exposed to the continuum of technological development from conceptual idea to testing at the basic, small animal, large animal, and human levels. Trainees will be advantaged by community strengths in basic, translational, and clinical science, training in cardiovascular innovation and entrepreneurship, and industry interactions and mentorship.

PI_NAMEs: CRAWFORD, PETER A;DUDLEY, SAMUEL C (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Cardiac;innovation;Training Programs

PROJECT_TITLE: Training Program in Cardiac Innovation

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-K (J2)]


ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE – OVERALL PPG  Addiction remains one of the world’s greatest public health problems, yet its pathophysiology remains incompletely understood and available treatments for addictions to various drugs of abuse are inadequately effective for most people. This Program Project Grant focuses on mechanisms of transcriptional and chromatin regulation in drug action on a cell-type-specific basis in brain reward regions. Our work is contributing to a better understanding of the neurobiological basis of stimulant and opioid addiction, which we believe is necessary for the eventual development of definitive treatments and cures for these substance use disorders.

PI_NAMEs: NESTLER, ERIC J. (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: addiction;Address;Affect;Animal Model;Animals;Automobile Driving;Autopsy;Back;Behavior;Behavioral;behavioral response;Bioinformatics;Biology;Brain;Brain region;brain reward regions;brain tissue;Cell Physiology;cell type;Chromatin;chromatin modification;chromatin remodeling;clinical translation;Code;Collaborations;Corpus striatum structure;Data;Data Set;desensitization;Development;DNA Modification Process;Dopamine D1 Receptor;Dorsal;drug action;Drug Addiction;Drug Exposure;drug of abuse;Enhancers;Exhibits;Eye;Female;Fiber;Functional disorder;Gene Expression;Gene Expression Regulation;gene function;Gene Transfer;Genes;Genetic;Genetic Transcription;Genome;genome-wide;Genomics;histone modification;Human;Individual;interest;Investigation;Knowledge;Learning;Link;male;Mediating;Mediator;Methods;Microglia;MicroRNAs;Mining;Modeling;Molecular;multidisciplinary;multiple datasets;Mus;Mutant Strains Mice;Neurobiology;Neuroglia;Neurons;neurophysiology;neuropsychiatry;novel;novel strategies;novel therapeutic intervention;Nucleus Accumbens;operation;Opiate Addiction;Opioid;optogenetics;Persons;Pharmaceutical Preparations;Photometry;pre-clinical;Procedures;Program Research Project Grants;programs;Proteins;Psychiatry;Public Health;Recording of previous events;Regulation;Relapse;Research;Research Personnel;response;Rest;RNA;RNA Splicing;Rodent;Self Administration;sex;Sex Differences;Stimulant;stimulant dependence;Stimulus;Substance Use Disorder;Syndrome;Tissues;tool;transcription factor;Transcriptional Regulation;Untranslated RNA;Validation;Variant;Viral;Viral Genes;women versus men;Work;Yasmin

PROJECT_TITLE: Transcriptional Mechanisms of Drug Addiction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-M (40)]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Genetics;Substance Misuse

PROJECT_TERMS: Adherence;Administrative Personnel;Advisory Committees;advocacy organizations;Applications Grants;Biomedical Research;Budgets;Career Choice;career development;Chromatin;Clinic;Collaborations;Communication;Communities;community organizations;complex data;COVID-19 pandemic;Creativeness;Data;Data Set;data sharing;Discipline;Diverse Workforce;Drug Addiction;Effectiveness;Ensure;Ethics;Evaluation;Faculty;Fostering;Funding;Gene Expression;General Population;Genetic Transcription;genome-wide;Goals;Grant;Human Resources;Individual;innovation;Institution;Interdisciplinary Study;Letters;Maintenance;meetings;member;Monitor;multidisciplinary;National Research Service Awards;New York;novel;Occupational activity of managing finances;Office of Administrative Management;outreach;pandemic disruption;Patient advocacy;Postdoctoral Fellow;Productivity;program dissemination;Program Research Project Grants;programs;Progress Reports;Publications;Reagent;recruit;Reproducibility;Research;Research Personnel;Research Project Grants;Resource Sharing;Safety Management;Schedule;Scientist;Series;skills;Software Design;Students;success;Time;timeline;Training Programs;Translations;Twitter;Underrepresented Populations;United States National Institutes of Health;Validation;Visit;web site;Woman;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: KENNY, PAUL J. (contact)

PROJECT_TERMS: addiction;Advisory Committees;Algorithms;Animal Model;Animals;Behavior;behavior test;Behavioral;Behavioral Assay;Biological Assay;Biotechnology;Blood Chemical Analysis;Blood drug level result;Brain;Brain region;brain reward regions;brain tissue;Cell Physiology;cell type;Cells;Chromatin;chromatin modification;cocaine self-administration;cohort;Collaborations;Committee Members;Complex;Continuous Infusion;Corticosterone;Data;Dissection;Dominant-Negative Mutation;drug action;Drug Addiction;Ensure;experimental study;Female;Fiber;gene function;Gene Transfer;Genes;Genetic;Genetic Transcription;genome-wide;Goals;Heroin;Human;Human Resources;Individual;inhibitor;injection/infusion;Injections;interest;Knock-out;Link;male;mature animal;Measurement;Measures;Mediating;meetings;Methods;Microdissection;Modeling;Molecular;Mus;mutant;Mutant Strains Mice;National Institute of Drug Abuse;neural circuit;Neuroglia;Neurons;neurophysiology;Neurosecretory Systems;novel;Nucleus Accumbens;Opiate Addiction;Opioid;optogenetics;osmotic minipump;overexpression;pain model;Pharmaceutical Preparations;Photometry;Plasma;Procedures;Process;Proteins;Rattus;Relapse;Research Personnel;Resources;RNA;Rodent;Rodent Model;Role;Running;Self Administration;Services;Specificity;statistics;Stimulant;stimulant dependence;Syndrome;Testing;tool;validation studies;Viral Vector;Work

PROJECT_TITLE: Animal Models Core


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: SHEN, LI  (contact)

PROJECT_TERMS: addiction;advanced analytics;Advisory Committees;analytical tool;Animal Model;Animals;ATAC-seq;Autopsy;Bioinformatics;bioinformatics infrastructure;bioinformatics tool;Biological Assay;bisulfite sequencing;Brain;brain cell;Brain region;brain reward regions;brain tissue;cell type;Cells;ChIP-seq;Chromatin;chromatin modification;Cleavage Under Targets and Release Using Nuclease;Cocaine use disorder;Collaborations;Communities;complex data;Data;Data Analytics;Data Set;data sharing;DNA Methylation;Drug Addiction;Enhancers;Ensure;epigenome;epigenome editing;Experimental Designs;Foundations;Gene Expression;Gene Expression Profiling;Genes;Genetic Transcription;genome-wide;genome-wide analysis;Goals;Human;Human Genome;Human Resources;human tissue;improved;in vivo;Individual;insight;interest;Laboratories;large datasets;Lead;Leadership;Logistics;Measures;meetings;member;Methods;Modeling;Molecular;Neuroglia;Neurons;novel;novel therapeutics;Nucleus Accumbens;Opiate Addiction;opioid use disorder;Progress Reports;Protocols documentation;Regulation;Research;Research Personnel;Resource Sharing;Resources;reward circuitry;Rodent;rodent genome;Rotation;Running;Sex Differences;stimulant dependence;Substance Use Disorder;success;Technology;Tissues;tool;transcriptome;transcriptome sequencing;transcriptomics;whole genome;Work

PROJECT_TITLE: Gene and Chromatin Analysis Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

PROJECT_TERMS: Acute;addiction;Affect;Animals;antagonist;Architecture;awake;Behavior;Behavioral;behavioral outcome;behavioral response;Binding;Binding Sites;Biology;Brain;Cell Physiology;cell type;Cells;ChIP-seq;Chromatin;chromatin modification;Cleavage Under Targets and Release Using Nuclease;Clinical;Cocaine;Cocaine Dependence;cocaine self-administration;Complex;Corpus striatum structure;CREB1 gene;Data;Data Set;DNA Sequence;Dorsal;drug action;Drug Addiction;drug of abuse;Exposure to;Female;Fiber;FOSB gene;Functional Magnetic Resonance Imaging;Funding;Gene Expression;Genes;Genetic Transcription;Genome;genome-wide;Goals;Human;improved;in silico;in vivo;inhibitor;insight;Investigation;knock-down;Laboratories;Link;Literature;male;Maps;Mediating;Methods;Modeling;Molecular;Motivation;Mus;neural;Neurons;neurophysiology;Neurosciences;novel;novel therapeutics;NPAS4 gene;NR4A1 gene;Nucleus Accumbens;Opiate Addiction;Opioid;overexpression;Peripheral;Phenotype;Photometry;Physiology;Play;Predictive Factor;Proteins;Rattus;Recording of previous events;Regulation;response;Response Elements;reward circuitry;Rewards;Rodent Model;Role;Site;Slice;small molecule;Stimulant;Tissues;Transcript;transcription factor;transcriptome sequencing;Translating;translational potential;Validation;virtual;Work

PROJECT_TITLE: Transcription Factors in Stimulant and Opioid Action


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

PROJECT_TERMS: 3' Untranslated Regions;Abstinence;AMPA Receptors;Back;Behavior;Behavioral;Binding;Biological Assay;Brain;cell type;Cells;Cocaine;cocaine seeking;cocaine self-administration;Collaborations;Complex;Corpus striatum structure;CREB1 gene;crosslinking and immunoprecipitation sequencing;cytokine;Disinhibition;Dorsal;Drug Addiction;Drug Controls;Drug Exposure;drug seeking behavior;Electric Stimulation;Extinction;Fluorescent in Situ Hybridization;Gene Expression;Genes;Genetic Transcription;Heroin;Human;Immunohistochemistry;Infusion procedures;innovation;Intake;Investigation;Knockout Mice;Laboratories;Link;Luciferases;Mediating;Messenger RNA;Microglia;MicroRNAs;Molecular;Motivation;Mus;Neuronal Plasticity;Neurons;neurophysiology;neurotransmission;novel;Nucleotides;Nucleus Accumbens;Opioid;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;Play;Population;posttranscriptional;programs;protective effect;protein expression;Rattus;Receptor Signaling;Regulation;Regulator Genes;Relapse;Research;Resolution;response;Ribosomes;RNA-Induced Silencing Complex;Role;Saline;Scheme;Self Administration;Signal Transduction;single-cell RNA sequencing;Stimulant;Synapses;Synaptic Transmission;Testing;TNF gene;Training;Transcript;transcription factor;transcriptomics;translating ribosome affinity purification and RNA-sequencing;Translational Repression;transmission process;Untranslated RNA;Whole-Cell Recordings;Work

PROJECT_TITLE: Micro-RNAs in Stimulant and Opioid Action


NIH_SPENDING_CATS: Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: SCHAEFER, ANNE  (contact)

PROJECT_TERMS: Ablation;Acute;addiction;Address;Adenosine;Affect;Attenuated;Behavioral;behavioral response;Brain;Brain region;cell type;Cells;Chronic;Cocaine;cocaine exposure;conditioned place preference;Corpus striatum structure;Couples;Data;Development;Disease;Dopamine;Dopamine D1 Receptor;Dorsal;Drug Addiction;Drug Exposure;drug induced behavior;drug of abuse;Enzymes;experimental study;Feedback;Follow-Up Studies;Functional disorder;Funding;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic;genetic approach;Genetic Transcription;Grant;Human;Immune;Induced Neurons;innovation;Interneurons;Investigation;Maps;Mediating;Microglia;Modeling;Monitor;Motor Activity;mouse model;Mus;Mutant Strains Mice;Neuroglia;neuronal survival;Neurons;neuroregulation;neurotransmission;novel;Nucleus Accumbens;Opioid;opioid exposure;Pathogenesis;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Play;prevent;Process;Production;promoter;Receptor Signaling;Regulation;response;Role;Self Administration;Signal Transduction;single nucleus RNA-sequencing;Stimulant;Substance Use Disorder;Synapses;Syndrome;Testing;Therapeutic Intervention;transcriptome sequencing;transcriptomics;transmission process;Work

PROJECT_TITLE: Microglia in Stimulant and Opioid Action


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

PI_NAMEs: HURD, YASMIN L. (contact)

PROJECT_TERMS: addiction;Address;Animal Model;Animals;Attention;Autopsy;axon guidance;Behavior;Behavioral;Bioinformatics;bioinformatics tool;Brain;Brain Diseases;Brain region;brain reward regions;Caring;Cell Maintenance;Cell Nucleus;cell type;Cells;Cellular Morphology;Cessation of life;Chromatin;Communities;Complex;Corpus striatum structure;COVID-19;Data;Data Set;Dendritic Spines;Development;Dorsal;Drug Addiction;drug addiction therapy;Economic Burden;Epidemic;Epigenetic Process;epigenome;experimental study;Family;Fentanyl;fentanyl self-administration;fentanyl use;Gene Abnormality;Gene Expression;Gene Expression Regulation;gene network;Genes;Genetic;Genetic Code;Genetic Transcription;Genome;Heroin;heroin use;Heroin Users;Histone H3;histone methyltransferase;Human;human tissue;Immune;Individual;inhibitor;insight;Intake;Knowledge;Laboratories;Lysine;Malignant Neoplasms;Mediating;Mediator;Medical;medication for opioid use disorder;Memory;Methylation;Modeling;Molecular;molecular pathology;Morphology;multiple omics;Mus;Neurobiology;Neuroglia;Neurons;non-opioid analgesic;novel;novel therapeutics;Nucleus Accumbens;Opioid;opioid epidemic;opioid misuse;opioid overdose;Opioid Rotation;opioid use;opioid use disorder;opioid user;Overdose;overdose death;Patients;Persons;Pharmaceutical Preparations;Phase;Play;Polycomb;Population;Process;Rattus;Regulation;Relapse;Repression;Research;Resolution;Resources;Rodent;Role;Science;Self Administration;Services;single cell sequencing;single nucleus RNA-sequencing;Sorting;stem;Stress;Techniques;tool;Transcription Alteration;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;translational approach;translational potential;Viral;virtual;Work

PROJECT_TITLE: Transcriptional Regulation In Human Opioid Use Disorders


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Diverse perspectives from diverse backgrounds and identities strengthen the research enterprise and enrich the research community, but leaky pipelines to advanced STEM degrees threaten our diversity goals. In this proposal, we address “leaks” or points where we risk attrition at each stage of neuroscience graduate education from precandidate to dissertation. Our focus on the intersections of diversity with mentoring, professional development, and advanced coursework and research opportunities helps us to “insulate” our pipeline, ultimately diversifying the field of neuroscience.

PI_NAMEs: DUNCAN, ROBERT KEITH (contact);ELIAS, CAROL FUZETI;FLAGEL, SHELLY BETH

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Address;Advanced Development;Affect;analytical tool;Area;Awareness;career;Career Choice;Career Mobility;career networking;cohort;Collaborations;Communication;Communities;community building;curriculum development;design;Development;Diverse Workforce;Doctor of Philosophy;doctoral student;Education;education research;Educational Curriculum;Educational Status;Educational workshop;Effectiveness;effectiveness evaluation;Ensure;Environment;equity, diversity, and inclusion;Evaluation;experience;Exposure to;externship;Faculty;Fostering;Future;Goals;Graduate Education;graduate school;graduate student;ImProv;Individual;Institution;Laboratories;Learning;lens;life span;marginalization;meetings;Mentors;Michigan;minority student;Modification;neural;Neurosciences;Neurosciences Research;novel;Outcome;Participant;pedagogy;programs;Records;Research;Research Personnel;Research Training;Resources;Risk;Schools;Self Efficacy;Series;skills;Structure;Students;success;symposium;System;Techniques;Training;Training Activity;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities

PROJECT_TITLE: Increasing Diversity: Targeting Transitions in the Neuroscience Graduate Education Continuum

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-L (25)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Pain Research

ORG_DEPT: OPHTHALMOLOGY

PHR: Chronic ocular surface pain is common, disabling, costly and treatments directed at the ocular surface are often ineffective. Instead, the source of pain maybe dysfunction of pain signaling and processing in the central nervous system similar to other chronic pain conditions, such as fibromyalgia. Our study seeks to define the role of central nervous system dysfunction in chronic ocular surface pain to impact diagnoses and treatments.

PI_NAMEs: DE LOTT, LINDSEY BLAKE (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Affect;Anesthetics;brain magnetic resonance imaging;Central Nervous System;Chronic;chronic pain;chronic painful condition;Clinical;clinical phenotype;cohort;Collaborations;Confocal Microscopy;conventional therapy;Cornea;cost;cost estimate;Data;Diagnosis;Disabling;Dry Eye Syndromes;Evaluation;Exhibits;experience;Eye;Eye Burns;Fatigue;Fibromyalgia;Functional disorder;Functional impairment;Functional Magnetic Resonance Imaging;High Prevalence;improved;in vivo;Individual;insight;Interstitial Cystitis;irritation;Laboratories;Measures;Mechanics;Mediating;Memory;Michigan;multimodality;multisensory;Nerve;Neurobiology;neuroimaging;Nociception;ocular pain;ocular surface;Ophthalmologist;Oral;Organ;Outcome Measure;Pain;Pain intensity;Pain management;pain perception;pain processing;pain relief;pain signal;Pain Threshold;Participant;Pathogenicity;Pathologic;Patient Outcomes Assessments;Patient Recruitments;patient subsets;Patients;Perception;Peripheral;Persistent pain;Persons;Pharmaceutical Preparations;Phenotype;Photosensitivity;Population;Quality of life;Recording of previous events;recruit;Reporting;Research;Research Personnel;response;Role;Sensory;Signal Transduction;Signs and Symptoms;Site;Sleep;somatosensory;Source;Symptoms;Syndrome;targeted treatment;Testing;Time;Topical application;treatment response;Universities;Work

PROJECT_TITLE: Central nervous system mechanisms and treatment response in chronic ocular surface pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Many microbes under study at UTMB are potential biological weapons as well as naturally emerging/re-emerging pathogens. To protect the world from intentional release of biological weapons, as well as from naturally emerging/re-emerging infectious diseases of potential pandemic nature, improved diagnostics, therapeutics, and vaccines are needed. Our training program capitalizes on UTMB’s unique high containment facilities, multiple highly qualified, world-renowned faculty, and robust biosafety educational programs to train doctoral students to become future successful independent researchers in academia and pharma working to develop novel medical countermeasures to curb highly consequential diseases.

PI_NAMEs: CHOPRA, ASHOK K (contact);ENDSLEY, JANICE J;WEAVER, SCOTT C

PROJECT_TERMS: biodefense;Training Programs

PROJECT_TITLE: Biodefense Training Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The Yale OAIC will promote the functional independence of older Americans by increasing scientific knowledge related to multifactorial geriatric conditions, by advancing the science of clinical decision making in multimorbid older persons, by educating and training early-stage investigators in aging research from a multifactorial perspective, and by developing and implementing innovative methods that will facilitate rigorous and high impact research on multifactorial geriatric conditions.

PI_NAMEs: GILL, THOMAS MICHAEL (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TITLE: Platelet UPR in aging and AD


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Chronic Pain;Neurosciences;Pain Research;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Chronic pain represents a major public health problem, and an improved understanding of the biopsychosocial contributors to pain is critical to inform interventions aimed at pain prevention and treatment. At present, there is a need to bolster the dwindling clinical pain research workforce. To address this gap, we propose the University of Florida Partnerships Across Interdisciplinary Networks: Training through Engineering, epidemiology & Addiction Medicine (UF PAIN TEAM) with the long-term goal of creating the next generation of team-trained clinical pain scientists. Working in teams, the UF PAIN TEAM will move the pain field forward through cutting edge research designed to elucidate the causes and reduce the burden of pain.

PI_NAMEs: ALLEN, KYLE D;CRUZ-ALMEIDA, YENISEL  (contact)

PROGRAM_OFFICER_NAME: LENZI, REBECCA N

PROJECT_TERMS: addiction;Applied Skills;Appointment;Area;biopsychosocial;career;career development;chronic pain;Clinical;clinical pain;Clinical Sciences;cohort;Collaborations;Communities;comorbidity;design;Development;Discipline;Doctor of Philosophy;effective intervention;Elements;Engineering;Epidemiology;experience;Faculty;Florida;Future;Goals;health equity;high standard;Knowledge;life span;Medicine;Mentors;Modeling;next generation;non-opioid analgesic;Nonpharmacologic Therapy;Pain;Pain management;pain model;Pain Research;Pharmacological Treatment;post-doctoral training;Postdoctoral Fellow;Prevention;programs;Research;Research Personnel;Research Training;response;responsible research conduct;Science;Scientist;skills;social health determinants;Training;Training Programs;Translating;Universities;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-F (90)]


NIH_SPENDING_CATS: Pediatric

ORG_CITY: EWING

ORG_NAME: COLLEGE OF NEW JERSEY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The College of New Jersey in collaboration with Mercer County Community College and Brookdale Community college proposes an engaging, research-intensive experience in order to develop a diverse and skilled local talent pipeline for the biomedical sciences, an area of rapid growth in the New Jersey region. Our program initiatives will prepare trainees to gain the knowledge, skills, and identity needed for successful biomedical careers, which will contribute to expanding the public health workforce.

PI_NAMEs: BAKER, JOSEPH ;CLEMENT, WENDY  (contact);CROWDER, JAMES ANTHONY;KRAMER, SUNITA GUPTA;NATALE III, PATRICK S

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Academic advising;Academic support;Agreement;Articulation;Associate Degree;Awareness;Bachelor's Degree;Biology;Biomedical Research;bridge to the baccalaureate;career;Chemistry;Collaborations;college;Communication;community building;community college;County;Development;Enrollment;expectation;experience;Financial Support;Goals;Grant;Institution;interest;Internships;Knowledge;Maps;Mentors;Modeling;New Jersey;Outcome;Pathway interactions;Problem Solving;programs;Research;Scholars Program;Science;Scientist;skills;Structure;student retention;Students;success;technology/technique;Training;university student

PROJECT_TITLE: New Jersey Biomed-Bridge (NJBB) Scholars Program: Supporting Central NJ Community College Students in their Transition to Biomedical Research Pathways at The College of New Jersey

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ORG_CITY: CHAMPAIGN

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative Literally hundreds of thousands of chemically distinct molecules are present in every cell in the brain and can be modified based on exposure to drugs of abuse, and yet the technologies to measure and elucidate this chemical complexity are not broadly available. Our Center offers unparalleled measurement capabilities and analytical support to a broad range of drug abuse and fundamental science projects, ensuring their success.

PI_NAMEs: SWEEDLER, JONATHAN V. (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: addiction;advanced analytics;American;analytical tool;Area;base;Behavior;Bioinformatics;Book Chapters;Brain;Brain region;Budgets;Catalogs;Cell Nucleus;Cell Separation;Cells;Chemicals;Communities;Complex;Cytoplasm;Data;Data Analytics;data mining;Disparate;Drug abuse;drug of abuse;Ensure;experimental study;Exposure to;Family;Funding;Genomics;Goals;high dimensionality;high throughput technology;Hormones;indexing;Individual;Informatics;innovation;instrumentation;intercellular communication;interest;Investigation;journal article;Journals;Learning;Lipids;macromolecular assembly;mass spectrometric imaging;Mass Spectrum Analysis;Measurement;Measures;Memory;metabolome;metabolomics;Methods;Molecular;Molecular Profiling;Molecular Target;Molecular Weight;Motivation;National Institute of Drug Abuse;Nature;Nervous System;neurochemistry;Neurons;Neuropeptides;neuroproteomics;Neurosciences;new technology;novel;Opioid;outreach;Pain;Pain management;patch clamp;Peptides;Pharmaceutical Preparations;Pilot Projects;predictive modeling;predictive tools;Printing;Progress Reports;prohormone;protein complex;Proteins;Proteome;Proteomics;Protocols documentation;Publications;Publishing;Relapse;Reporting;Research;Research Personnel;Research Project Grants;Resources;response;Rewards;Sampling;Science;Scientific Advances and Accomplishments;Series;Services;small molecule;Societies;Structure;success;synergism;System;Technology;Testing;tool;transcriptomics;user-friendly;web platform;web services

PROJECT_TITLE: Neurometabolomics and Neuroproteomics Center on Cell-Cell Signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SXC-E (M1)]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PROJECT_TERMS: Advisory Committees;base;Bioinformatics;Biological;Book Chapters;Brain;Cell Nucleus;Cells;Communities;Consultations;Data Analyses;Data Analytics;data management;Drug abuse;Drug Addiction;Drug Exposure;drug of abuse;Ensure;Equipment;Evaluation;Exposure to;Fostering;Funding;Goals;Illinois;innovation;intercellular communication;Interdisciplinary Study;International;Investigation;journal article;Manuscripts;Measurement;meetings;metabolomics;Molecular Profiling;Monitor;National Institute of Drug Abuse;Nature;Nervous System;Neurons;neuroproteomics;Neurosciences;Neurosciences Research;new technology;NIH Program Announcements;operation;Organization administrative structures;organizational structure;Output;outreach;Peptides;Pilot Projects;predictive modeling;Printing;Productivity;Proteins;Proteomics;Protocols documentation;Publications;Publishing;Recording of previous events;Research;Research Project Grants;Resource Allocation;Resources;response;Role;Running;Sampling;Schedule;Scientific Advances and Accomplishments;Series;Services;Signal Transduction;small molecule;Structure;success;synergism;System;Technology;technology development;Time;Training and Education;Universities;Work


PROJECT_TERMS: addiction;Address;Affect;analytical tool;Animal Model;Area;Awareness;base;Behavioral;Bioinformatics;Biological;Biological Assay;Brain;Brain region;brain tissue;Cattle;Cell Nucleus;Cells;Chemicals;Chemistry;Communities;Complex;Data Analytics;design;Development;DNA;Drosophila genus;drug action;Drug Addiction;Drug Exposure;drug of abuse;Drug usage;Drug user;Education;empowerment;Equipment;experimental study;Familiarity;Foundations;Fractionation;Funding;Heterogeneity;Individual;innovation;intercellular communication;interest;Investigation;Link;Lipids;Mass Spectrum Analysis;Measurement;Measures;metabolome;metabolomics;Methodology;Methods;Molecular;molecular imaging;Molecular Profiling;Morphology;National Institute of Drug Abuse;Nervous System;neurochemistry;Neurons;neuroproteomics;Neurosciences;Neurosciences Research;Neurotransmitters;Organ;Organelles;Outcome;Pathway interactions;Peptides;Philosophy;Physiological;predictive modeling;Preparation;Process;Protein Analysis;Proteins;Proteome;Proteomics;Protocols documentation;Psyche structure;Research;Research Personnel;Research Project Grants;Rest;RNA;Sample Size;Sampling;Science;Services;Signal Transduction;small molecule;Spatial Distribution;success;synergism;System;Techniques;Technology;temporal measurement;Tissue Sample;Tissues;Withdrawal;Work

PROJECT_TITLE: Sampling and Separation


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PI_NAMEs: KELLEHER, NEIL L (contact)

PROJECT_TERMS: addiction;Address;Animal Model;Astrocytes;Bioinformatics;Brain;brain cell;Brain Chemistry;Brain region;brain tissue;brain volume;Capillary Electrophoresis;Categories;Cell Communication;Cell Culture Techniques;Cell Nucleus;Cells;Cellular Structures;chemical property;Chemicals;Chromatography;Collaborations;Communities;Complex;Controlled Study;Coupled;Data;Data Analytics;data quality;Data Set;detection method;Development;Dimensions;Dissociation;Drug abuse;Drug Addiction;drug withdrawal;experimental study;Future;G-Protein-Coupled Receptors;Health;Heart;Hormones;Illinois;Image;imaging approach;Individual;innovation;intercellular communication;Investigation;Ions;Knowledge;Label;Ligands;Liquid Chromatography;liquid chromatography mass spectrometry;macromolecular assembly;mass spectrometer;mass spectrometric imaging;Mass Spectrum Analysis;Measurement;Measures;Mediating;Membrane Proteins;Metabolism;metabolome;metabolomics;Methods;Microglia;Mind;Mission;model organism;Modification;Molecular;Molecular Analysis;Molecular Profiling;Molecular Weight;monomer;nano;National Institute of Drug Abuse;Neurobiology;neurochemistry;Neurologic;Neuronal Plasticity;Neurons;Neuropeptides;neuroproteomics;operation;Pain management;Pathway interactions;Performance;Phase;physical property;Positioning Attribute;Post-Translational Protein Processing;predictive modeling;Process;protein complex;Proteins;Proteomics;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resolution;Resources;Role;Sampling;Shotguns;Signal Transduction;Site;Slice;small molecule;Spatial Distribution;Specificity;Spectrometry, Mass, Electrospray Ionization;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;structural biology;Structure;System;tandem mass spectrometry;Techniques;Technology;temporal measurement;tissue culture;Tissue Extracts;Tissues;tool;Universities;Withdrawal

PROJECT_TITLE: Molecular Profiling & Characterization


NIH_SPENDING_CATS: Bioengineering;Data Science;Drug Abuse (NIDA only);Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research;Substance Misuse

PI_NAMEs: RODRIGUEZ ZAS, SANDRA L (contact)

PROJECT_TERMS: Address;Adoption;analytical tool;Artificial Intelligence;Atlases;Behavior Disorders;Big Data to Knowledge;Bioinformatics;bioinformatics pipeline;bioinformatics resource;Biological Markers;Brain;Catalogs;Cell Signaling Process;Cells;Communities;Complex Mixtures;Data;Data Analyses;Data Analytics;data mining;deep learning;design;Development;Dimensions;Drug abuse;Drug Exposure;education resources;Educational Materials;Educational workshop;empowerment;epigenomics;experimental study;Goals;Human;innovation;intercellular communication;Journals;large language model;Link;Machine Learning;Metabolic;metabolomics;Mining;Minority-Serving Institution;Mission;Molecular;Molecular Profiling;Multiomic Data;multiple omics;Mus;National Institute of Drug Abuse;Neuropeptide Gene;Neuropeptides;neuroproteomics;Neurosciences Research;Noise;Output;Pain;pain perception;Peer Review;Peptides;Physiological;Play;pre-clinical;predictive modeling;predictive tools;Process;protein complex;Protein Isoforms;Proteins;Proteomics;public repository;Publications;Reporting;Reproducibility of Results;Research;Research Personnel;Research Project Grants;Research Support;Resources;response;Role;Sampling;Scholarship;Sequence Alignment;Services;Signal Transduction;skills;sound;Students;success;Technology;Testing;tool;Training;Training and Education;Transcript;transcriptomics;United States National Institutes of Health;Update;user-friendly;web portal;web services

PROJECT_TITLE: Bioinformatics, Data Analytics and Predictive Modeling


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PI_NAMEs: ROMANOVA, ELENA V (contact)

PROJECT_TERMS: Acceleration;Achievement;addiction;Address;Area;Automobile Driving;Award;base;Bioinformatics;Biomedical Research;Cells;Collaborations;Communities;Data;Data Analytics;Dedications;Development;Discipline;Drug Addiction;Drug usage;empowerment;Ensure;Evaluation;experience;Feasibility Studies;Feedback;follow-up;Follow-Up Studies;Fostering;fundamental research;Funding;Funding Agency;Future;Genetic;Goals;improved;Individual;Informatics;innovation;insight;Institution;intercellular communication;interest;Link;Measurement;Methodology;Mission;Molecular Profiling;National Institute of Drug Abuse;Neuronal Plasticity;Neuropeptides;neuroproteomics;Neurosciences;Neurosciences Research;novel;opioid use disorder;Outcome;Outcomes Research;Oxycodone;Phase;Phenotype;Pilot Projects;predictive modeling;Process;programs;Proteins;Public Health;Qualifying;receptor;recruit;Research;Research Personnel;Research Project Grants;Resources;Role;Sampling;Science;Scientific Evaluation;Scientist;Services;Societies;Staff Development;Substance abuse problem;substance use;Talents;Technology;Thinking;tool;transcriptomics

PROJECT_TITLE: Pilot Research


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: R25 MSK Computational Biology Summer Program: Project Narrative The MSK Computational Biology Summer Program (CBSP) aims to train the next generation of computer science savvy students in cancer biology. Biologists are trained to form a hypothesis and provide data to support it, but in the current big data era, many can’t find the insights they seek in the vast troves of data they’ve collected. CBSP participants, through exposure to cancer biology topics, can use their skills to develop new tools and mine big data towards finding the next generation of cancer therapeutics, patient diagnostics, and furthermore, can uncover novel biological and mechanistic insights into cancer.

PI_NAMEs: BERGER, MICHAEL F. (contact);NEILL, USHMA

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;anti-cancer research;Awareness;Basic Science;Big Data;Biological;Biology;Biomedical Research;Cancer Biology;cancer education;cancer therapy;career;Caring;Clinical Research;Collaborations;Computational Biology;computational pipelines;Computer Interface;computer science;course development;Data;Dedications;design;Development;Diagnosis;Diagnostic;Discipline;Education;education research;Ensure;Epigenetic Process;experience;Exposure to;Faculty;Fostering;Future;Genome;Genomics;Goals;graduate student;Image;innovation;insight;Institution;interest;International;Internships;Investments;Journals;Knowledge;Laboratories;Laboratory Research;Learning;lectures;Malignant Neoplasms;Mathematics;Medicine;meetings;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;Methods;methylation pattern;Needles;next generation;novel;Oncology;Participant;Patients;Perception;personalized genomics;personalized medicine;Postdoctoral Fellow;posters;Prevention;programs;recruit;repaired;Research;Research Personnel;Research Project Grants;Series;Shapes;skills;student training;Students;summer program;summer student;symposium;Therapeutic;tool;Training;undergraduate student;Universities;Work


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE The Cardiovascular Sciences Training Program is dedicated to preparing the next generation of scientists who aim to understand the normal and abnormal function of the heart and vascular system. Heart and vascular diseases remain a leading killer of Americans, and therefore, we need to have investigators who are well trained in this field. As cardiovascular disease has evolved and our understanding of it has changed, over this next training period, we have added mentors who are experts in bioinformatics and systems analysis to take better advantage of large biomedical data sets that will help us better diagnose and treat cardiovascular disease.

PI_NAMEs: DECARA, JEANNE M;GILAD, YOAV  (contact);IM, HAE KYUNG ;MOSKOWITZ, IVAN PAUL

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TITLE: Cardiovascular Sciences Training Grant

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM (JA)]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: Project Narrative The focus of our work is to better understand the mechanisms of lysosomal glycogen metabolism. Our goal is to translate knowledge gained about lysosomal glycogen metabolism into better ways to diagnose and treat genetic diseases where lysosomal glycogen metabolism is dysregulated, such as Pompe disease and Danon disease, or metabolic diseases where glycogen metabolism is dysregulated including cancer, heart disease, diabetes, and brain disease.

PI_NAMEs: HEDEN, TIMOTHY D. (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Address;Autophagocytosis;Award;Brain Diseases;career;Cells;Cellular biology;Cellular Metabolic Process;Cytosol;Diabetes Mellitus;Diagnosis;Disease;Enzymes;flexibility;forging;Freedom;Genetic Diseases;genetically modified cells;Glucose;glucose metabolism;Glycogen;Glycogen Debranching Enzyme;glycogen metabolism;Glycogen Phosphorylase;Glycogen storage disease type II;Glycogen Storage Disease Type IIb;glycogenolysis;Goals;Grant;grasp;Health;Heart Diseases;Influentials;innovation;interdisciplinary collaboration;Knowledge;Lysosomal Storage Diseases;Lysosomes;Malignant Neoplasms;Mediating;Mentors;Metabolic Diseases;Metabolism;Mus;novel;Pathway interactions;Process;recruit;Research;Role;Shunt Device;tool;Training;Translating;Underrepresented Populations;Vision;Work

PROJECT_TITLE: Defining the mechanisms of the glycophagy shunt and its role in metabolism

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE The objective of this T32 Training Grant is to educate and train basic scientists and physician-scientists conducting high impact and innovative research that will improve the health of people suffering from lung diseases. We aim to recruit and train trainees from diverse backgrounds, and provide multifaceted and personalized training opportunities that will endow our trainees with the skills required to become successful independent researchers, educators, and policy makers in lung biology and pulmonary medicine.

PI_NAMEs: GEORAS, STEVE N (contact);O'REILLY, MICHAEL A

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TITLE: Multidisciplinary Training in Pulmonary Research


PHR: Project Narrative This renewal pre- and post-doctoral training program in translational Immunology will continue to attract pre- doctoral PhD and MD/PhD as well as post-doctoral MD, PhD and MD/PhD candidates into a comprehensive training environment to teach them cutting edge immunology relevant to human disease inclusive of but not limited to autoimmune disease, allergies, immunodeficiencies, cancer, and transplantation.

PI_NAMEs: EDELBLUM, KAREN LEIGH (contact);LIRA, SERGIO A.

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TITLE: Translational Immunology Training Program

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]