NIH_SPENDING_CATS: Biotechnology;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse

ORG_CITY: STOCKTON

ORG_NAME: UNIVERSITY OF THE PACIFIC-STOCKTON

PHR: Narrative: Around two thirds of overdose deaths involved illicit synthetic opioids like fentanyl, which is the primary driver of the opioid epidemic today. Current opioid antidotes (naloxone and nalmefene) are not very effective in situation involving synthetic opioids. The overall goal of this project is to develop a fundamentally novel drug delivery approach for extending the duration of action and efficacy of currently FDA-approved opioid overdose antidotes.

PI_NAMEs: ALHAMADSHEH, MAMOUN M (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: absorption;Adderall;Adverse effects;American;antagonist;Antidotes;Binding;blood-brain barrier crossing;blood-brain barrier penetration;Brain;Buprenorphine;carfentanil;Cessation of life;Cocaine;Dangerousness;design;Development;Dose;Drug Delivery Systems;Drug Kinetics;efficacy evaluation;efficacy testing;Ensure;Esters;Evaluation;FDA approved;Fentanyl;fentanyl analog;fentanyl overdose;first responder;Funding;Generations;Goals;Happiness;Hepatocyte;Heroin;high school;Human Resources;Hybrids;Hydrolysis;hydrophilicity;Illicit Drugs;In Vitro;in vivo;Ingestion;Law Enforcement;Life;Ligands;mass casualty;Metabolic;Methamphetamine;Military Personnel;milligram;Monitor;Morphine;mu opioid receptors;nalmefene;Naloxone;novel therapeutics;Opioid;Opioid Antagonist;opioid epidemic;opioid mortality;opioid overdose;opioid use disorder;opioid withdrawal;Overdose;overdose death;Patient-Focused Outcomes;Patients;Percocet;Persons;Pharmaceutical Preparations;Phase;pill;Prealbumin;Precipitation;prevent;Prevention;Prodrugs;Public Health;Rattus;Renal clearance function;Reporting;Respiration;Risk;Safety;School-Age Population;Series;Serum;Serum Proteins;side effect;subcutaneous;Subcutaneous Tissue;synthetic opioid;System;Testing;Time;Toxic effect;United States;Ventilatory Depression;weapons;Whole Body Plethysmography;Withdrawal Symptom;Xanax

PROJECT_TITLE: A novel drug delivery system for the prevention and rescue of fentanyl and other opioid overdoses

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Liver Disease

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PI_NAMEs: PAJVANI, UTPAL  (contact)

PROJECT_TERMS: Academic Medical Centers;Achievement;Adult;Applications Grants;Award;career;career development;Categories;Childhood;Clinical;clinical center;Collaborations;Data;Development;Digestive System Disorders;Doctor of Philosophy;Education;Educational workshop;Eligibility Determination;equity, diversity, and inclusion;experience;Extramural Activities;Faculty;falls;FarGo;Funding;Funding Mechanisms;Future;Goals;Grant;Grant Review;Growth;high reward;high risk;innovation;Institution;Investments;Liver diseases;Medical center;member;Mentors;Mentorship;Mission;Monitor;next generation;operation;Outcome;Peer Review;programs;Publications;Qualifying;Recording of previous events;Research;Research Personnel;Research Project Grants;Resources;Science;scientific organization;Scientist;Services;success;Talents;Training;United States National Institutes of Health;Universities

PROJECT_TITLE: Pilot and Feasibility Program


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

PI_NAMEs: QUE, JIANWEN  (contact)

PROJECT_TERMS: 3-Dimensional;Basic Science;biobank;Biomedical Engineering;Biomedical Research;Biophysics;career;Career Choice;career development;Cellular biology;Clinical;Clinical Investigator;Collaborations;collaborative environment;Complement;Data;Dedications;design;Development;Digestive System Disorders;disadvantaged background;Doctor of Philosophy;doctoral student;Education;education research;Educational workshop;Effectiveness;Ensure;Environment;Epidemiology;Equilibrium;equity, diversity, and inclusion;experience;Faculty;Fertilization;Fostering;Gender;Genetic;Goals;Grant;Immunology;innovation;Institution;Laboratory Research;lectures;Liver;Liver diseases;Manuscripts;Medical center;Medical Students;Medicine;meetings;member;Mentors;Mentorship;Methodology;Microbiology;mid-career faculty;Mission;Neurology;Neurosciences;next generation;Organ;Pancreas;Pathology;Pediatrics;Pharmacology;Physiology;Postdoctoral Fellow;professor;programs;Records;Research;Research Personnel;Resources;sabbatical;Science;Scientist;Series;symposium;synergism;Systems Biology;Techniques;Technology;Training;Training Activity;Training and Education;training opportunity;Underrepresented Minority;Universities;Update;Visit;Work

PROJECT_TITLE: The Enrichment Program


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Data Science;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Narrative Antibiotic resistance (AR) is a substantial threat to public health. By utilizing advances in sequencing technology and machine learning, we propose novel deep learning models to 1) predict AR for many combinations of bacteria and antibiotics; 2) provide personalized performance AR prediction models for chronic infections; 3) disseminate cloud-ready, scalable, and user-friendly online resource. This work can potentially lead to rapid, precise antibiotic prescriptions leading to effective treatments for infectious diseases and integrate the latest advances in data science for the AR research community.

PI_NAMEs: GREENBERG, DAVID ELIHU;ZHAN, XIAOWEI  (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: algorithm development;Algorithms;Anti-microbial susceptibility;Antibiotic Resistance;Antibiotic susceptibility;Antibiotics;antimicrobial;artificial intelligence model;Bacteria;Bacterial Antibiotic Resistance;Bacterial Drug Resistance;Bacterial Genome;Bacterial Infections;Biological Assay;chronic infection;Clinical;cloud based;cohort;Collection;Combined Antibiotics;Communicable Diseases;Communities;community engagement;computerized tools;cost;Culture Techniques;Custom;Cystic Fibrosis;Data;Data Collection;Data Science;deep learning;deep learning model;design;Development;Diagnosis;Diagnostic;effective therapy;Electronic Health Record;emerging pathogen;empowerment;Ensure;Epidemiology;Face;falls;Feedback;Foundations;Generations;genome sequencing;genomic data;Goals;in silico;Individual;infectious disease treatment;informatics tool;Infrastructure;innovation;interest;Laboratories;large datasets;Machine Learning;machine learning algorithm;machine learning model;machine learning prediction;Mass Spectrum Analysis;Methodology;Methods;microbial;Modeling;Molecular;novel;online resource;Online Systems;open source;Organism;Output;pathogen;pathogenic bacteria;Patient Care;Patients;Pattern;Performance;Pharmaceutical Preparations;Phenotype;phenotypic data;Physicians;prediction algorithm;predictive modeling;Procedures;Process;programs;prospective;Proteins;Public Health;Pulmonary Cystic Fibrosis;Reproducibility;Research;Research Personnel;Resistance;Resistance development;resistance mechanism;Resources;Sampling;Solid;Specimen;Speed;Techniques;Technology;Test Result;Testing;Time;tool;tool development;transfer learning;usability;user-friendly;Validation;Variant;Visualization software;web site;whole genome;Work

PROJECT_TITLE: Antibiotic Resistance Determination Utilizing Machine Learning


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Neurosciences;Pain Research;Pediatric;Sleep Research

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative: Functional abdominal pain disorders (FAPD), one of the most common chronic pain conditions are associated with significant disability, school absenteeism and suboptimal outcomes. Improved treatment strategies are urgently needed but hampered by an incomplete understanding of contributing factors like sleep disturbances. Objectively characterizing sleep architecture through polysomnography in relation to gastrointestinal symptoms will pave the way for newer treatment targets modulating sleep or optimize existing treatments like percutaneous electrical nerve field stimulation to improve clinical outcomes.

PI_NAMEs: SANTUCCI, NEHA RICHARD (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Abdominal Pain;Absenteeism;actigraphy;Adolescent;Adult;Affect;Aftercare;Anxiety;Behavioral Medicine;Case/Control Studies;Center for Translational Science Activities;central pain;Child;Childhood;chronic pain;chronic painful condition;Clinical;clinical efficacy;Clinical Research;clinical translation;Clinical Trials;cohort;Cranial Nerves;Data;Dedications;Development;Devices;diaries;disability;disorders of gut-brain interaction;effective therapy;Environment;Eye;Foundations;Frequencies;Funding Opportunities;Gastroenterologist;Gastroenterology;gastrointestinal;gastrointestinal symptom;Gastrointestinal tract structure;Goals;Grant;Health;Health Care Costs;improved;improved outcome;improvement on sleep;innovation;Institution;Intervention Trial;Intestines;Learning;Master of Science;Measures;Mediating;Mediation;Medical center;Mental Depression;Mentors;Monitor;Movement;Nausea;Nerve;Nociception;Nociceptors;non rapid eye movement;novel;Outcome;Pain;Pain Disorder;Pain Measurement;pain processing;Pathway interactions;Patient Outcomes Assessments;Patient Self-Report;Patients;Pediatric Hospitals;Pediatrics;Persons;Pharmaceutical Preparations;Physicians;Physiological Processes;Polysomnography;predicting response;Predictive Factor;professor;programs;psychologic;Questionnaires;Records;Reporting;Research;Research Design;Research Personnel;Research Training;Resources;response;Risk Factors;Role;Schools;Scientist;Severities;Sleep;Sleep Architecture;Sleep disturbances;Sleep Fragmentations;sleep pattern;sleep physiology;sleep quality;Sleep Stages;Sleeplessness;Slow-Wave Sleep;Statistical Data Interpretation;Statistical Methods;Symptoms;Time;Training;Translational Research;Treatment outcome;treatment response;treatment strategy;trend;Vagus nerve structure;Visit;Work;Wrist;Youth

PROJECT_TITLE: Disrupted sleep architecture in adolescents with functional abdominal pain disorders

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Precision Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Many individuals with autism spectrum disorder exhibit larger brain volumes early in life. We will generate and study cortical organoids from individuals with ASD and matched controls who have been profiled with behavioral assessments and neuroimaging since infancy in order to identify cellular and molecular mechanisms leading to early brain overgrowth. Insight into these mechanisms will enable further understanding of disease pathogenesis, delineate convergent biological pathways within a heterogeneous disorder, and will identify therapeutic targets for early personalized treatments.

PI_NAMEs: STEIN, JASON LOUIS (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: Age Months;Area;autism spectrum disorder;autism symptoms;Behavior;Behavior assessment;behavior measurement;Behavioral;Biological;Biological Models;Biological Process;Blood;Brain;Brain imaging;brain overgrowth;brain size;brain volume;cell behavior;Cell Cycle;Cell Line;cell type;Cells;Clinical;cognitive ability;cohort;Control Groups;Development;Diagnosis;Diagnostic;Disease;Exhibits;Family;Gene Expression;Generations;Genotype;Growth;high risk;imaging study;In Vitro;in vivo;in vivo Model;Individual;Individual Differences;individual variation;individuals with autism spectrum disorder;induced pluripotent stem cell;infancy;Infant;insight;inter-individual variation;Life;Light;Measurement;Measures;Microscopy;Modeling;Molecular;Molecular Profiling;neocortical;nerve stem cell;neurodevelopment;neurogenesis;neuroimaging;Neurons;Organoids;Outcome;Participant;Pathogenesis;Pathway interactions;Peripheral Blood Mononuclear Cell;personalized medicine;Phenotype;phenotypic data;Play;Population;postnatal;proband;Proliferating;Reporting;Resources;Risk;Role;Sampling;Sampling Studies;School-Age Population;serial imaging;Siblings;single-cell RNA sequencing;stem cell organoids;stem cell proliferation;Structure;Surface;System;therapeutic target;Time;Tissues;Validation;Variant

PROJECT_TITLE: IBIS-iPSC: Organoid modeling of cortical surface area hyperexpansion in autism spectrum disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MDCN-P(57)]


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: HANOVER

ORG_DEPT: MISCELLANEOUS

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Knowledge of the spatial distribution of elements within cells, organs and tissue can help inform mechanisms of human disease, diagnosis, and treatment. Building on an established core we will create the Biomedical National Elemental Imaging Resource (BNEIR) to promote and facilitate the use of elemental imaging within the biomedical community.

PI_NAMEs: JACKSON, BRIAN P (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Ablation;Acceleration;Aluminum;Alzheimer's Disease;Antibodies;Area;Arsenicals;base;Basic Science;beamline;Biochemical;bioimaging;Biological Markers;Biological Process;biological systems;Biology;biomedical facility;biomedical resource;Brain;cancer therapy;Cell Cycle Regulation;Cell Physiology;Cells;Centers of Research Excellence;Chemicals;Coenzymes;cofactor;Collaborations;college;Communities;Computer software;Consult;Contrast Media;Copper;Custom;Cytometry;data acquisition;Data Analyses;data handling;Detection;detection limit;Diagnosis;diagnostic tool;Disease;disease diagnosis;Doctor of Philosophy;Drug Delivery Systems;drug efficacy;Drug Targeting;E-learning;Elements;Ensure;experience;experimental study;Fees;Fluorescence;Fostering;Foundations;Funding;Gadolinium;Goals;Health;Hepatolenticular Degeneration;Homeostasis;Human;Human body;human disease;Human Resources;Image;Imaging Techniques;Immunity;Immunohistochemistry;improved;Inductively Coupled Plasma Mass Spectrometry;industry partner;Infrastructure;innovation;Institution;instrumentation;International;Internet;Iron;Isotopes;Knowledge;Laboratories;Lasers;Life;Lifting;Light;Link;Location;Magnetic Resonance Imaging;mass spectrometer;medical schools;meetings;metalloenzyme;Metals;Mission;Molecular;nanoparticle;National Institute of General Medical Sciences;Online Systems;Organ;Organism;Performance;Persons;Platinum Compounds;Prevention;Process;programs;Proteins;repaired;Reproduction;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;response;Roentgen Rays;Role;Science;Scientist;Selenium;Senile Plaques;Services;software development;Source;Spatial Distribution;Spectrometry, Mass, Secondary Ion;Spottings;success;synchrotron radiation;Synchrotrons;System;Techniques;Technology;Therapeutic;Time;Tissues;Trace Elements;Training;Training Programs;United States National Institutes of Health;Vacuum;Visit;webinar;Work;Zinc


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: The Vanderbilt Institute for Clinical and Translational Research (VICTR) is a highly functional and integrated clinical and translational (C&T) research infrastructure that has raised the quality and rigor of the research conducted at Vanderbilt and partner Meharry Medical College. VICTR will contribute to the mission of the CTSA program, leveraging unique resources and expertise, while elevating and advancing the role of health equity in C&T research.

PI_NAMEs: BERNARD, GORDON RAPHAEL;SELF, WESLEY H (contact);WILKINS, CONSUELO HOPKINS

PROGRAM_OFFICER_NAME: GOPAL-SRIVASTAVA, RASHMI

PROJECT_TERMS: Academic Medical Centers;Acceleration;Black race;Clinical Research;Clinical Sciences;Collaborations;Communities;community engagement;COVID-19 mortality;design;Disease;drug repurposing;Economics;Ensure;Equity;ethnic minority population;Foundations;Funding;Health;health disparity;health equity;Health equity research;Health Sciences;Healthcare;Healthcare Systems;Home;Homelessness;Imprisonment;improved;Incidence;Inequity;Informatics;informatics tool;Infrastructure;innovation;Institution;International;Knowledge;Learning;medical schools;Methodology;Methods;Mission;Morbidity - disease rate;Multi-Institutional Clinical Trial;multidimensional data;novel;operation;pandemic disease;Pharmaceutical Preparations;Population;pragmatic trial;Process;programs;Race;racial minority population;Research;Research Infrastructure;Research Methodology;Research Personnel;Resources;Role;Science;skills;social;success;System;Textiles;Time;Translational Research;Translations;trial design;Vision;voucher


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: EAST LANSING

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative The ubiquitous ZIP metal transporters play central roles in transition metal homeostasis of living organisms with an emerging role in cell signaling. The fourteen ZIPs encoded in human genome participate in numerous physiological processes and are also associated with many diseases, including cancers. This proposal aims to clarify the structural and molecular basis of transport, substrate specificity and post-translational regulation mechanisms of the ZIPs, which will ultimately improve human health and environmental protection.

PI_NAMEs: HU, JIAN  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Agriculture;Biochemical;Biological;Biological Process;Biology;Biophysics;Buffers;Cadmium;cancer type;Catalysis;Cells;chemical property;Communities;Disease;Environment;Environmental Protection;Family;Family member;Five-Year Plans;Gene Expression Regulation;Goals;Health;Health protection;Homeostasis;Human;Human body;Human Genome;improved;Iron;macromolecule;Malignant Neoplasms;Membrane Transport Proteins;Metabolism;Metals;Molecular;Organism;Overdose;Physiological Processes;Plants;Play;Post-Translational Regulation;preference;programs;Protein Engineering;Protein Family;Proteins;Regulation;Research;Role;Signal Transduction;Soil;Structure;Substrate Specificity;success;Toxic effect;Trace Elements;transcription factor;Transition Elements;uptake;Work;Zinc;zinc-binding protein

PROJECT_TITLE: Transport, substrate specificity and regulation mechanisms of the ZIP transition metal transporters

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: ATHENS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE The ideal antibacterial and hemocompatible surface would prevent platelet adhesion and activation, thrombosis, and microbial biofilm formation. This research project will develop and evaluate the synergistic effects of S- nitrosothiol based nitric oxide (NO) release along with a surface immobilized catalyst that can extend the therapeutic levels of NO for longer periods at the polymer interface to prevent platelet activation/adhesion and provide antimicrobial activity, thereby solving major clinical problems associated with extracorporeal circuit (ECC) applications and enabling successful ECC without heparinization.

PI_NAMEs: BRISBOIS, ELIZABETH JOY (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Address;Adhesions;analytical method;Anti-Bacterial Agents;Anticoagulation;antimicrobial;Attention;Bacteria;Bacterial Infections;Binding;Blood;Blood Coagulation Disorders;Blood Platelets;Blood Vessels;Blood-Borne Pathogens;Candida albicans;Cannulas;catalyst;Catheters;Cell Line;Cells;Clinical;clinical application;clinical development;Coagulation Process;Complication;covalent bond;COVID-19;COVID-19 pandemic;COVID-19 patient;Critical Illness;Data;Devices;early phase clinical trial;Embolism;Exhibits;Extracorporeal Circulation;Extracorporeal Membrane Oxygenation;Formulation;Generations;Goals;Heart failure;Hematological Disease;hemocompatibility;Hemodialysis;Hemorrhage;Heparin;high risk;Immobilization;improved;In Vitro;in vitro Bioassay;Infection;infection rate;Lead;Legal patent;Life;Measures;Mechanical ventilation;Microbial Biofilms;Modeling;N-acetylpenicillamine;Nitric Oxide;Nitric Oxide Donors;Nosocomial Infections;Obstruction;Oryctolagus cuniculus;Oxygenators;Patient Admission;Patient Care;Patients;Platelet Activation;polydimethylsiloxane;Polymers;prevent;Prevention;Property;Pseudomonas aeruginosa;Pulmonary Thromboembolism;Reporting;Research Project Grants;Respiratory Failure;Risk;S-Nitrosothiols;Safety;Selenium;Sepsis;Staphylococcus aureus;Staphylococcus epidermidis;Sterilization;success;Surface;synergism;System;Technology;Testing;Therapeutic;thrombogenesis;Thrombophilia;Thrombosis;thrombotic complications;Thrombus;Time;Translations;Tube;Vascular Endothelial Cell;Work

PROJECT_TITLE: Heparin-free extracorporeal circulation via combined nitric oxide releasing/generating surfaces

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: CHARLES R. DREW UNIVERSITY OF MED & SCI

ORG_STATE: CA

PHR: PROJECT NARRATIVE The Charles R. Drew University of Medicine and Science (CDU) and the University of California, Los Angeles (UCLA) propose the Engaging Students in Aging Research (ESAR) program, which will provide underrepresented racial/ethnic minority community college students in the Los Angeles Community College District (LACCD) with a longitudinal, community based participatory research experience to increase exposure and career interest as researchers focused on the health of minority older adults.

PI_NAMEs: BAZARGAN, MOHSEN  (contact);KERMAH, DULCIE

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Academic skills;Advocate;African American;Aging;aging related;Associate Degree;Atmosphere;Awareness;Biomedical Research;California;career;Career Choice;Clinical Research;Collaborations;college;Communities;community academic partnership;community based participatory research;community college;community engaged approach;community engagement;community partners;Country;cultural competence;Degree Completion;design;Disadvantaged;Disparity;Education;Educational workshop;Effectiveness;Enrollment;Environment;environment health training;ethnic minority;Evaluation;evidence base;experience;Exposure to;Extended Family;Faculty;faculty community;Fostering;fundamental research;Future;Generations;Goals;Growth;Health;Health Disparities Research;Healthcare;higher education;Immersion;improved;innovation;insight;Institution;Institutionalization;interest;K-12 Education;Knowledge;late life;Latinx;Linguistics;Los Angeles;Low income;matriculation;Medical Care Team;Medicine;member;Mentors;Mentorship;Methodology;minority communities;minority health;minority student;Modeling;Monitor;multidisciplinary;older adult;Older Population;Outcome;Pathway interactions;peer coaching;Population;professional students;programs;Qualitative Research;racial minority;racism;recruit;Reporting;Research;Research Activity;Research Personnel;Research Training;resilience;Resources;Science;Science, Technology, Engineering and Mathematics;Scientist;Secondary Schools;skills;STEM field;STEM program;student participation;student training;Students;Supervision;System;systemic barrier;Talents;Training;training opportunity;Training Programs;undergraduate student;United States;Universities;university student;urban area;Work

PROJECT_TITLE: Engaging Underrepresented Racial/Ethnic Minority Students in Aging Research


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: OVERALL NARRATIVE Building on a rich bank of population and clinical studies, the Harvard Chan School-NIEHS Center for Environmental Health is applying the best available technologies and methods to re-envision the complex lived environment exposure landscape, assess it, and address related health effects in our population studies. This includes new opportunities offered by the “‘omics” era, with a particular new emphasis on the microbiome, to reveal the mechanisms of emerging environmental threats. We aim to work with the local community to guide the understanding and analysis of the lived environment and to make our research results immediately translatable to community concerns through public policy and other prevention efforts.

PI_NAMEs: WEISSKOPF, MARC G (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Address;Affect;Air Pollutants;Animal Model;Area;Bioinformatics;Biological;Chemicals;clinical practice;Clinical Research;Communication;Communities;community engagement;Complex;Complex Mixtures;Core Facility;Ensure;Environment;Environmental Exposure;Environmental Health;Epidemiology;evidence base;Fostering;Foundations;Future;gene environment interaction;Geography;Goals;Growth;Health;Health Policy;Health Sciences;Human;Human Biology;human subject;in vitro Model;Individual;Interdisciplinary Study;Investigation;Laboratories;Laboratory Study;Leadership;Measures;member;Metals;method development;Methods;microbiome;microbiome research;Modernization;multidisciplinary;National Institute of Environmental Health Sciences;next generation;Organic Chemicals;Outcome;particle;Particulate Matter;Pathway interactions;Patients;Persons;Population;population based;Population Study;Prevention;Productivity;Public Health;Public Policy;Research;Research Personnel;Resources;Risk;Schools;Science;Seminal;statistics;stressor;success;Technology;technology development;tool;Toxic Environmental Substances;Toxicant exposure;Toxicology;Training;Translating;Universities;Work

PROJECT_TITLE: Harvard Chan School NIEHS Center for Environmental Health

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(P)]


PROJECT_TERMS: Administrator;Advisory Committees;Appointment;Area;career development;Chalk;Communication;Communities;community advisory board;community building;community engagement;Core Facility;Development;Discipline;Educational workshop;Effectiveness;Ensure;Environmental Exposure;Environmental Health;Evaluation;Feedback;Fostering;Grant;Health;Health Professional;Incubators;Infrastructure;inter-institutional;Leadership;lectures;Medical;meetings;Monitor;multidisciplinary;National Institute of Environmental Health Sciences;Newsletter;operation;outreach;Pilot Projects;Productivity;programs;Public Health Schools;Publications;Recommendation;Reporting;Research;Research Personnel;Resources;Schools;senior faculty;Shapes;Talents;Translational Research;Translations;Universities;web site;Work

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS]


PI_NAMEs: PARK, JIN-AH  (contact)

PROJECT_TERMS: Area;Biological;biomarker development;biomarker discovery;Cells;Core Facility;Development;Disease;disorder risk;Early Diagnosis;Environment;environmental chemistry;Environmental Exposure;Environmental Health;Equipment;Future;Genomics;Goals;Health Sciences;Health Services;improved;instrumentation;Measurement;Medical;Methods;microbiome;Molecular;National Institute of Environmental Health Sciences;Population;Population Study;Postdoctoral Fellow;preventive intervention;Research;Research Personnel;Resources;Sampling;Schools;Scientist;Services;student training;Technology;Training;translational goal;Translational Research

PROJECT_TITLE: Integrated Health Service Facility Core


NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: COULL, BRENT ANDREW (contact)

PROJECT_TERMS: analysis pipeline;Area;Bayesian Method;Bioinformatics;Biometry;Biostatistics Core;Community Health;Community Outreach;Computational Biology;Computer software;computerized tools;Data;data management;Data Science;design;Development;Educational Activities;Environmental Epidemiology;Environmental Health;epidemiological model;Faculty;Genetic;Genomics;graduate student;Health;Individual;Infrastructure;Interdisciplinary Study;interest;Journals;Measurement;Measures;meetings;member;Methodology;Methods;Mission;Modeling;National Institute of Environmental Health Sciences;Paper;Reproducibility;Research;Research Activity;Research Methodology;Research Personnel;Schools;Science;Services;spatiotemporal;Statistical Models;statistics;Teacher Professional Development;University resources;web page;Work;working group

PROJECT_TITLE: Environmental Statistics and Biostatistics Core


NIH_SPENDING_CATS: Behavioral and Social Science;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: LADEN, FRANCINE  (contact)

PROJECT_TERMS: Area;Behavioral;Behavioral Sciences;Biometry;Censuses;Characteristics;Collaborations;Collection;community center;community engagement;Community Outreach;contextual factors;Core Facility;Data;data management;Data Sources;demographics;digital phenotyping;Educational Activities;Educational workshop;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Health;Environmental Science;Epidemiology;Faculty;field study;Geographic Factor;Geographic Information Systems;Geography;graduate student;health data;Health Sciences;Infrastructure;Interdisciplinary Study;interest;Joints;Longitudinal cohort;Measures;member;Metals;Methodology;National Institute of Environmental Health Sciences;Neighborhoods;particle;predictive modeling;Privacy;Publications;Research;Research Activity;Research Personnel;Resolution;Resources;Sampling;Schools;Science;Series;Services;smartphone application;social;Social Sciences;stressor;Training;web site;Work

PROJECT_TITLE: Geographic & Contextual Measures Core


NIH_SPENDING_CATS: Genetics;Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The work conducted under this proposal will provide further insight into the regulative role of senescent cells within microenvironments in vivo. Leveraging the tools already developed and acquiring new state of the art techniques, we will identify the SASP factors of p16INK4a+ lung fibroblasts at homeostasis and during acute alveolar injury. The knowledge gained through this study will provide clarity on the role SASP from p16INK4a+ plays in regulating epithelial alveolar regeneration.

PI_NAMEs: REYES DE BARBOZA, NABORA SOLEDAD (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: 3-Dimensional;Acute;Address;Adult;Age;Aging;airway epithelium;airway regeneration;Alleles;Alveolar;alveolar epithelium;Alveolus;Anatomy;Architecture;Basement membrane;Behavior;Bioinformatics;biological adaptation to stress;Biological Assay;Biology;Biotinylation;career development;CDKN2A gene;Cell Aging;Cell Cycle;cell growth;Cell Size;cell type;Cells;Characteristics;Coculture Techniques;Cyclin-Dependent Kinase Inhibitor 2A;Cyclins;cytokine;Dasatinib;Data;Dependence;Development;DNA Damage;environmental stressor;epithelial injury;epithelial stem cell;Epithelium;epithelium regeneration;Excision;experimental study;Fibroblasts;Foundations;Gases;Gene Expression Profile;Genetic;Genetic Transcription;Goals;Growth;Growth Factor;Homeostasis;IL6 gene;Immune;immune cell infiltrate;Immune system;in vivo;Inflammatory;inhibitor;injured airway;Injury;injury and repair;insight;knock-down;Knowledge;Lead;Ligands;Lung;lung regeneration;Matrix Metalloproteinases;Mediating;Metabolic;Modeling;Mus;Names;Natural regeneration;Nature;novel;Oncogenic;Organoids;Phase;Play;Polyploidy;Population;programs;Proliferating;Protein Secretion;Proteomics;Protocols documentation;Pulmonary alveolar structure;Quercetin;receptor;repaired;Reporter;Resistance;response;response to injury;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;single-cell RNA sequencing;skills;stem cell growth;stem cell proliferation;stem cells;Stimulus;Stress;stressor;Surface;Techniques;Testing;tissue repair;Tissues;tool;TP53 gene;Training;transcriptome;transcriptome sequencing;transcriptomics;Tumor Escape;Tumor Suppressor Proteins;tumorigenesis;Up-Regulation;Work;wound healing;young adult

PROJECT_TITLE: p16INK4a+ fibroblasts regulate epithelial regeneration after injury in lung alveoli through the SASP

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(JA)]


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: OVERALL NARRATIVE ChicAgo Center for Health and EnvironmenT (CACHET)”, the first NIEHS P30 environmental health sciences core center in the Chicago area, was established in 2017 as a collaboration between the University of Chicago and University of Illinois at Chicago. Leveraging the experience and progress made over the past 3.5 years, CACHET will continue to promote multidisciplinary environmental health research among clinician, laboratory and population scientists from two Chicago area universities with complementary strengths and structure to understand, evaluate and ultimately reduce environmental health related disparities among residents of the region and beyond.

PI_NAMEs: AHSAN, HABIBUL  (contact);PRINS, GAIL S

PROJECT_TERMS: Address;Agreement;Air;Area;Behavioral;Biological;Biological Markers;career development;Cell Physiology;Chicago;Cities;cohort;Collaborations;collaborative environment;college;Communication;Communities;community engagement;community partners;Core Facility;COVID-19 pandemic;Critiques;data repository;Dedications;Disease;Disparity;distinguished professor;Doctor of Philosophy;effective intervention;Environment;environmental disparity;Environmental Exposure;Environmental Health;Environmental Impact;Epidemiology;ethnic disparity;ethnic health disparity;experience;Fertilization;Focus Groups;Fostering;Funding;Goals;Group Structure;Health;Health Disparities Research;health inequalities;health science research;health science research support;Health Sciences;Health Services Accessibility;human disease;Human Genetics;Illinois;improved;Infrastructure;Institution;inter-institutional;Interdisciplinary Study;Laboratories;Leadership;Medicine;member;microbiome;Mission;Molecular;multidisciplinary;National Institute of Environmental Health Sciences;organizational structure;Outcome;Pathology;Physiology;Pilot Projects;Policies;Policy Maker;pollutant;Population;Predisposition;professor;Program Development;programs;Published Comment;racial disparity;racial health disparity;recruit;Research;Research Personnel;Resources;Risk;Scientist;service member;Shapes;social;social disparities;Soil;Structural Racism;Structure;Subgroup;success;synergism;Time;tool;Toxic effect;Translating;Translations;United States National Institutes of Health;Universities;urban area;Urology;Water


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: ADAMKIEWICZ, GARY  (contact)

PROJECT_TERMS: Address;Adopted;Air Pollutants;analytical tool;Area;Bioinformatics;Boston;Censuses;Childhood;Collaborations;Communities;Community Actions;community engagement;community organizations;Community Participation;community partners;Core Facility;Data;data tools;data visualization;Disasters;Educational workshop;Effectiveness;effectiveness evaluation;Environmental Exposure;Environmental Health;environmental health disparity;environmental justice;Environmental Risk Factor;Event;expectation;Exposure to;Facility Accesses;Faculty;Festival;Fostering;Funding;Funding Mechanisms;Geography;Goals;Grant;Health;Health education;health equity;Health Professional;Health Sciences;Human;Incubators;Laws;Leadership;Lived experience;Maps;Massachusetts;Measurable;Measures;medical specialties;meetings;member;Metal exposure;Mission;Modeling;National Institute of Environmental Health Sciences;Neighborhoods;North Carolina;novel strategies;Organic Chemicals;outreach;Particulate;Persons;Pilot Projects;Policies;Pollution;Population;programs;prospective;Public Health;Recovery;Regulation;Research;Research Personnel;Research Project Grants;Resources;Sampling;Schools;Science;Services;socioeconomics;Statistical Data Interpretation;statistics;stressor;Structure;synergism;Translating;Translations;Universities;Vision;Work

PROJECT_TITLE: Community Engagement Core


PI_NAMEs: WARD, MALLORY RACHAEL (contact)

PROJECT_TERMS: Address;Area;Biological Markers;career development;Chicago;Cities;Communication;Communities;community engagement;community organizations;community partners;Core Facility;Databases;Disparity;Education;Educational workshop;Ensure;Environment;Environmental Health;environmental health disparity;Environmental Risk Factor;ethnic health disparity;Evaluation;Exposure to;Faculty Recruitment;Focus Groups;Fostering;Goals;Grant;Health;health science research;Health Sciences;Human Resources;Illinois;improved;Infrastructure;inter-institutional;Justice;Leadership;Marketing;meetings;member;Mission;Monitor;Multimedia;National Institute of Environmental Health Sciences;next generation;Occupational activity of managing finances;operation;Outcome;Pilot Projects;Program Development;programs;Progress Reports;Public Health;Publications;Race;racial health disparity;Recommendation;Records;recruit;Research;Research Activity;Research Personnel;Resources;Services;social media;Strategic vision;Supervision;System;Targeted Research;tool;Translational Research;Universities;web site;Work

PROJECT_TITLE: CACHET - Admin Core


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: HART, JAMIE  (contact)

PROJECT_TERMS: Area;Award;career;career development;Communities;Creativeness;Data;Discipline;Environmental Health;Facility Accesses;Feedback;Fostering;Funding;Funding Agency;Goals;Grant;Growth;Heart;innovation;Investments;Laboratories;Manuscripts;Medical;Medicine;National Institute of Environmental Health Sciences;Notification;Pathway interactions;Peer Review;Pilot Projects;Productivity;programs;Publications;Research;Research Personnel;Research Project Grants;Research Support;Schools;sound;United States National Institutes of Health;Work

PROJECT_TITLE: Pilot Project Program


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: ASCHEBROOK-KILFOY, BRISEIS A (contact)

PROJECT_TERMS: Abbreviations;Address;Area;arm;Arsenic;biobank;Biological;Biological Assay;Biological Markers;biomarker development;Biometry;Cancer Center;Chicago;Clinic;Clinical;Clinical and Translational Science Awards;clinical center;Clinical Sciences;cohort;Collaborations;Collection;Communities;community collaboration;community engagement;complex data;Computer software;Computerized Medical Record;Consent;Core Facility;Data;Data Analyses;Data Analytics;Data Collection;data management;design;Detection;Development;Devices;Disease;disorder prevention;Disparity;Dust;Early Diagnosis;electronic data;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Health;environmental health disparity;environmental justice;epidemiology study;Equipment;Ethics;ethnic health disparity;Ethnic Origin;Evaluation;Federally Qualified Health Center;Focus Groups;Food;fundamental research;Funding;Health;health data;health science research;Health Sciences;Hispanic Community Health Study/Study of Latinos;Human;human biological material;Human Resources;human tissue;Illinois;implementation study;improved;indoor air;Information Dissemination;Infrastructure;innovation;Institution;Institutional Review Boards;Knowledge;Leadership;Longitudinal Studies;Measurement;Medical;member;Methods;Minority Health Research;Mission;mobile application;mobile computing;Modeling;Modernization;Molecular;multi-ethnic;National Health and Nutrition Examination Survey;novel;Organizational Efficiency;Outcome;Participant;Particulate Matter;Personnel Recruitments;Pilot Projects;Population;population based;population health;Population Heterogeneity;Precision Health;Prevention;Principal Investigator;programs;quality assurance;Questionnaires;Race;racial health disparity;recruit;Research;Research Design;Research Personnel;Research Project Grants;Research Training;Resources;sample collection;Sampling;sensor;Services;Source;Statistical Data Interpretation;Statistical Methods;statistical service;study population;surveillance study;targeted biomarker;Techniques;Technology;tissue resource;tool;Training;Translating;translational health science;Translational Research;translational study;Universities;Water;wearable device;Work

PROJECT_TITLE: CACHET - IHSFC


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the discovery of mechanisms by prevalent bacterial members of the human gut microbiome colonize the gut and regulate intestinal inflammation is expected to lead to new approaches for modifying microbiome composition and new treatments for the human inflammatory bowel diseases and other inflammatory disorders. The proposed research is therefore relevant to the part of NIH’s mission that pertains to developing fundamental new knowledge that will enhance health and reduce the burdens of illness.

PI_NAMEs: RAWLS, JOHN F (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Acceleration;Affect;Animal Model;Animals;Anti-Inflammatory Agents;Bacteroides;Biology;burden of illness;Clinical Management;Communities;Comparative Genomic Analysis;Complex;Development;Diagnostic;Disease;Ecology;fitness;Genes;Genetic;Genetic Annotation;Genetic Determinism;genetic information;genetic strain;Genetic Variation;Genome;Genomics;Gnotobiotic;Goals;gut bacteria;gut colonization;gut inflammation;gut microbes;gut microbiome;gut microbiota;Health;Human;human disease;Human Microbiome;human model;humanized mouse;Immune response;Immunity;improved;in vivo;Individual;Infant;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Knowledge;Life;Link;lipid transport;Lipids;Mass Spectrum Analysis;Mediating;member;Metabolic;Metabolic Diseases;microbial;microbiome;microbiome composition;microbiome research;Mission;mouse model;Mus;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Operon;Outcome;Pathway interactions;personalized therapeutic;Phenotype;Physiology;Polycystic Ovary Syndrome;Population;prognostic;Prognostic Marker;Public Health;Regulation;Research;Rodent;Structure;Testing;Therapeutic;Therapeutic Uses;trait;United States National Institutes of Health;Variant

PROJECT_TITLE: Genetic determinants of Bacteroides vulgatus colonization fitness and host inflammatory responses

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Endocrine Disruptors;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Microbiome;Social Determinants of Health

PI_NAMEs: MINSHALL, RICHARD D (contact)

PROJECT_TERMS: Abbreviations;Address;Air;analytical method;Bioinformatics;Biological;Biological Assay;Biological Markers;Biological Models;bisphenol A;Blood;Chicago;Communities;Core Facility;cost effective;Cost Sharing;Coupled;Data;Data Analyses;Data Reporting;design;Disease;DNA;DNA sequencing;Environment;Environmental Exposure;Environmental Health;Environmental Pollutants;epigenomics;Exposure to;Family;Feces;Fourier transform ion cyclotron resonance;Funding;Gas Chromatography;gene environment interaction;Genetic Predisposition to Disease;Genomics;Goals;Health;health inequalities;health science research;Heavy Metals;Herbicides;High Pressure Liquid Chromatography;host microbiome;Human Microbiome;human subject;Illinois;Inductively Coupled Plasma Mass Spectrometry;Institution;instrumentation;Investments;Liquid Chromatography;Liquid substance;MALDI-TOF Mass Spectrometry;Mass Spectrum Analysis;Measurement;member;metabolomics;Metagenomics;microbial;microbiome sequencing;microbiota;Mission;Monitor;National Institute of Environmental Health Sciences;oxidation;Performance;Pesticides;Physiological;Plasma;Poison;Poly-fluoroalkyl substances;Population Dynamics;Predisposition;Proteomics;Reaction;Research;research facility;Research Personnel;Research Project Grants;Resources;Saliva;Sampling;Services;small molecule;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Steroids;tandem mass spectrometry;Time;Toxic Environmental Substances;Toxicogenomics;transcriptomics;treatment response;ultra high pressure;Universities;Volatile Fatty Acids;Water

PROJECT_TITLE: CACHET - Environmental Biomarkers Core


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Address;Advocacy;Air Pollution;Area;Asian;Behavioral;Biological;Black race;Black, Indigenous, People of Color;Categories;Censuses;Chicago;Cities;Coal;Collaborations;collaboratory;Communication;Communities;community advisory board;community engaged research;community engagement;community organizations;community partners;community partnership;Country;Diabetes Mellitus;Disease;dissemination strategy;Economics;Environment;Environmental Exposure;Environmental Hazards;environmental justice;Environmental Pollutants;Ethnic Origin;ethnic segregation;experience;Exposure to;Face;Funding;Goals;hazard;Health;health equity;Hispanic;Home;Hypertension;Illinois;implementation strategy;improved;indexing;Infrastructure;Institution;interest;Investments;Justice;knowledge translation;Lead;Leadership;Malignant Neoplasms;manufacture;Measures;Mission;Mothers;Movement;Neighborhoods;Not Hispanic or Latino;novel;Outcomes Research;people of color;Persons;Policies;Politics;pollutant;Pollution;Population;Population Heterogeneity;Positioning Attribute;Power Plants;Process;Production;Public Health Schools;Race;Racial Segregation;racism;Recording of previous events;Recovery;Reporting;Research;Research Activity;research and development;Research Personnel;Risk;Risk Factors;Scientist;segregation;Side;social;social vulnerability;Solid;Source;Steel;Translational Research;Universities;ward;Water Pollution

PROJECT_TITLE: CACHET - CEC Core


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: SAN DIEGO

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE This study leverages available data from four randomized controlled trials (RCTs) that tested interventions to promote HIV care continuum engagement among some of the most socially and medically vulnerable populations in the world, specifically people living with HIV with co-occurring drug use in the U.S., Asia, and Eastern Europe. We will maximize the data to their full potential by analyzing mediators and moderators of efficacy in affecting biological HIV care continuum outcomes (viral suppression, CD4, mortality). The study will improve evaluation methods and measures in future RCTs testing interventions among vulnerable populations.

PI_NAMEs: PITPITAN, EILEEN VIRTUSIO (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Acceleration;Address;advanced analytics;Advisory Committees;Affect;AIDS prevention;Asia;Automobile Driving;Behavior Therapy;Behavioral;Biological;care outcomes;Caring;Clinic;Communities;condomless anal sex;contingency management;Continuity of Patient Care;cost effective intervention;Counseling;Data;Diving;Drug usage;Drug user;Eastern Europe;Epidemic;Evaluation;Evaluation Research;Face;follow-up;Funding;Future;Goals;Guidelines;high risk;HIV;HIV prevention trials network;HIV Seropositivity;Hospitals;Housing;implementation barriers;improved;improved outcome;Incidence;Individual;Indonesia;injection drug use;insight;Intervention;intervention effect;Intervention Trial;Knowledge;Light;Masks;Measures;Mediating;Mediation;Mediator;medical vulnerability;men;men who have sex with men;Mental Depression;Methods;Modeling;mortality;Outcome;Pathway interactions;patient navigation;Patients;Persons;Pharmaceutical Preparations;Population;Prevention trial;preventive intervention;primary outcome;Principal Investigator;Process;psychosocial;Publishing;Randomized, Controlled Trials;Reduce health disparities;Reporting;Research;Research Personnel;Resources;Review Literature;Role;Russia;Science;secondary analysis;social stigma;Social support;social vulnerability;stimulant use;Subgroup;substance use;Substance Use Disorder;success;System;systematic review;Techniques;Testing;theories;therapy design;Time;tool;Treatment Efficacy;trial design;Ukraine;United States National Institutes of Health;Vietnam;Viral;Vulnerable Populations

PROJECT_TITLE: Estimating Mediation and Moderation Effects in HIV Care Continuum Intervention Trials for People who Use Drugs


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MUTLU, GOKHAN M. (contact)

PROJECT_TERMS: Abbreviations;Acceleration;Address;Applications Grants;Area;Aryl Hydrocarbon Receptor;Award;Biological Markers;career;career development;Cell Physiology;Chicago;Clinical and Translational Science Awards;clinical center;Clinical Sciences;Collaborations;Communities;community based research;community collaboration;community engagement;community research;Core Facility;Data;design;Development;Discipline;Disparity;Environment;Environmental Exposure;Environmental Health;environmental justice;Environmental Risk Factor;ethnic health disparity;Faculty;Focus Groups;Fostering;Funding;Funding Agency;Future;Grant;Growth;Health;health disparity;health science research;Health Sciences;high reward;high risk;Illinois;innovation;Institution;inter-institutional;Leadership;member;Mentors;Methods;Molecular;National Institute of Environmental Health Sciences;next generation;non-alcoholic fatty liver disease;Occupational Health;Participant;Pilot Projects;Program Development;programs;Progress Reports;Public Health Schools;Publications;racial health disparity;recruit;Request for Applications;Research;Research Personnel;Research Project Grants;Resources;response;SARS-CoV-2 infection;success;Testing;Toxic effect;Translational Research;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: CACHET - Pilot Project


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breast Cancer;Breastfeeding, Lactation and Breast Milk;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_DEPT: PHYSIOLOGY

PHR: The proposed research is relevant to public health because understanding the mechanism behind transcriptional regulation of mammary development is essential for lactation. In addition, this will serve to elucidate the role of the repressor E2Fs in mammary development and function. Thus, the proposed research is relevant to the NIH mission of understanding growth and development by understanding how E2F transcription factors regulate development of the mammary gland.

PI_NAMEs: ANDRECHEK, ERAN ROBERT (contact)

PROGRAM_OFFICER_NAME: BROCKWAY, HEATHER MARIE

PROJECT_TERMS: Ablation;Address;Adult;Alveolar;Biology;Breast Epithelial Cells;Cell Cycle;Cell Cycle Regulation;cell type;Cells;ChIP-seq;Clustered Regularly Interspaced Short Palindromic Repeats;Color;conditional knockout;Data;Data Set;Databases;Defect;Development;Developmental Gene;Duct (organ) structure;E2F transcription factors;Embryo;Ensure;Excision;Gene Expression;gene repression;Genes;Genetic;Genetic Transcription;Gland;Goals;Growth;Growth and Development function;Hydrocephalus;Image;In Vitro;in vivo evaluation;inducible Cre;innovation;Knock-out;Knockout Mice;Laboratories;Lactation;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;mammary epithelium;Mammary gland;mammary gland development;Mediating;Mission;Mus;offspring;Outcome;Pathway interactions;Pattern;Phase;Phenotype;Play;Pregnancy;Process;programs;Puberty;Public Health;Publishing;reconstitution;Regulation;Reporter;Repression;Research;Role;Signal Pathway;single cell analysis;single cell genomics;single-cell RNA sequencing;Sorting;Tamoxifen;Testing;Tissues;Transcription Coactivator;Transcription Repressor;Transcriptional Regulation;United States National Institutes of Health;Validation;Weaning;Work

PROJECT_TITLE: Transcriptional regulation of mammary gland development

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Diabetes;Prevention

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE Recent advances in technology are opening the door to exciting new therapeutic strategies for treating diabetes and its complications. Despite a need for a new generation of technologically-skilled translational research leaders, individuals with rigorous analytical science backgrounds who are cross-trained in diabetes research and drug development are rare. The PROMT T32 training program addresses this need by providing a unique predoctoral learning experience focused on leading-edge training in state-of-the-art technologies, translational diabetes research and therapeutic development with an emphasis on providing students from underrepresented groups the structured support needed to thrive as scientific leaders.

PI_NAMEs: NATARAJAN, RAMA ;THURMOND, DEBBIE C (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TITLE: DIABETES PREVENTION / RISK / OMICS / METABOLISM / THERAPY (PROMT) INTERDISCIPLINARY TRAINING

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: Project Narrative Clonal hematopoiesis (CH) is an aging associated condition characterized by the clonal outgrowth of mutated pre-leukemic cells. Individuals with CH are at an increased risk of developing hematopoietic malignancies, however the genetic and molecular alterations that cooperate to induce myeloid malignancies in individuals harboring CH-associated mutations remain largely uncharacterized. The impact of this grant application is highly significant, as it (1) provides critical insight into the progression of pre-leukemic states to overt myeloid malignancies, (2) describes a novel tumor suppressor, and (3) has translational implications and fills an unmet clinical need for genetically and phenotypically defined subtypes of AML and MPN.

PI_NAMEs: AIFANTIS, IANNIS ;STARCZYNOWSKI, DANIEL  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acetylation;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Affect;aging related;Agonist;Applications Grants;Binding;Biological Assay;Cell Physiology;Cells;Clinical;Data;Development;Disease;disorder subtype;DNMT3a;Dysmyelopoietic Syndromes;Evolution;Gene Expression;Gene Expression Profiling;Genetic;Genetic Models;Goals;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic stem cells;Human;human disease;Hypermethylation;Immune signaling;improved;in vivo;Individual;innate immune pathways;insight;leukemia;Leukemic Cell;Leukemic Hematopoietic Stem Cell;Link;loss of function;Lysine;Malignant - descriptor;Mediating;Messenger RNA;Modeling;Modification;Molecular;mouse model;Mus;Mutate;Mutation;Myeloid Leukemia;Myeloproliferative disease;novel;Oncogenic;Outcome;Pathway interactions;Patients;Phenotype;Post-Translational Protein Processing;Preleukemia;promoter;protein expression;Proteins;Proteomics;Regulation;Repression;Risk;RNA interference screen;RNA Splicing;Role;self-renewal;Signal Transduction;small hairpin RNA;stem;stem cell function;stem cells;Therapeutic;Toll-like receptors;TRAF6 gene;transcriptome;tumor;Tumor Suppressor Proteins;Ubiquitin;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Dissecting innate immune signaling in pre-leukemia evolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-C(02)M]


ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE - OVERALL The Environmental Health Sciences Research Center (EHSRC) is the primary environmental health sciences resource for improving the health of rural residents by stimulating and translating innovative environmental health sciences research. This is accomplished by supporting original research addressing rural exposures; population health; susceptibilities; and pathways of toxicity, disease, and repair to enhance environmental health literacy, public health practice, regulatory policy, new clinical treatments, and precision environmental health. The EHSRC supports five Thematic Areas which serve as intellectual hubs, three research facility cores, a Pilot Grant Program, a Career Enhancement Program and a Community Engagement Core that collectively develop fundamental knowledge about living systems to enhance health and reduce the burden of human disease, with an emphasis on rural populations.

PI_NAMEs: LEHMLER, HANS-JOACHIM  (contact)

PROJECT_TERMS: Address;Agriculture;Air Pollution;Animal Model;Applications Grants;Area;biomedical imaging;career;Career Mobility;Chemicals;Childhood Asthma;Clinical;Clinical Treatment;Collaborations;college;community engagement;Community Health;Computer Models;Core Facility;cost effective;Data;Data Analytics;data to knowledge;Disasters;Disease;Dust;Educational workshop;Effectiveness;Ensure;Environmental Health;Environmental Impact;Environmental Pollutants;Equipment;Exposure to;Face;Farm;Fostering;Future;Goals;Grant;Grooming;Health;health knowledge;health literacy;Health Resources;health science research;Health Sciences;human disease;improved;Individual;Industrialization;Inflammasome;Inflammation;Inhalation;innovation;insight;Institution;Interdisciplinary Study;interest;Iowa;Knowledge;Leadership;Livestock;Lung;Lung Diseases;lung imaging;Malignant Neoplasms;manufacture;meetings;member;Mentors;microbiome;Midwestern United States;Monitor;nanoscience;National Institute of Environmental Health Sciences;Natural Immunity;novel;Organism;Oxidation-Reduction;Pathway interactions;pesticide exposure;Physicians;Policies;Population;population based;population health;Population Study;Predisposition;Production;programs;Public Health;Public Health Practice;recruit;repaired;Research;research facility;Research Personnel;research vision;Resources;Role;Rural;rural America;rural dwellers;rural environment;Rural Health;Rural Population;Science;Scientist;sensor;Services;Strategic vision;Techniques;Technology;Toxic effect;toxicant;Toxicology;Training;Translating;Translational Research;Translations;Universities;Vision;Wages;Water Pollution;water quality;Work


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

PROJECT_TERMS: Administrator;Advisory Committees;Animals;Applications Grants;Area;Articulation;Award;base;Biometry;Budgets;career;college;Committee Members;community engagement;Complex;Core Facility;data to knowledge;Doctor of Philosophy;Effectiveness;effectiveness research;Ensure;Environmental Engineering technology;Environmental Health;Extramural Activities;Fostering;Functional Imaging;Goals;Grant;Head;Health;health science research;Health Sciences;Hypersensitivity;Image;Immunity;Inflammation;Institution;Leadership;Lung;Managed Competition;meetings;member;Mentors;mid-career faculty;multidisciplinary;nanoscience;National Institute of Environmental Health Sciences;Natural Immunity;operation;Oxidation-Reduction;Pediatrics;Play;population health;Productivity;professor;programs;Public Health;Publications;Radiology Specialty;Reporting;Research;Research Personnel;Research Project Grants;Resources;Role;Science;Services;Specialist;Strategic Planning;success;Therapeutic;Toxicology;Training;Translating;translational engagement;Translational Research;Universities;Vision;water quality;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Nutrition

ORG_CITY: ATLANTA

ORG_DEPT: SURGERY

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative Hydrogen sulfide (H2S) as a cytoprotective-signaling molecule. However, there are still questions regarding how the endogenous production of H2S is regulated and the identification of physiologically relevant protein targets and signaling pathways regulated by H2S. Our proposed studies aim to offer insights into both of these questions.

PI_NAMEs: CALVERT, JOHN WINTER (contact);ORTLUND, ERIC A

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: 3-Mercaptopyruvate sulfurtransferase;5'-AMP-activated protein kinase;Acute;Affect;Anabolism;Attention;beta-mercaptopyruvate;Biology;Cardiac;cardioprotection;Cardiovascular Diseases;Cardiovascular system;combat;Cystathionine beta-Synthase;Cysteine;Cysteine Desulfhydrase;Cytoprotection;Data;Development;Diabetes Mellitus;diet-induced obesity;Energy Metabolism;Enzymes;Experimental Models;experimental study;genetic approach;Heart;Heart failure;High Fat Diet;Hydrogen Sulfide;In Vitro;in vivo;insight;Ischemia;Lipid Mobilization;Lipids;Mitochondria;Myocardial Reperfusion Injury;novel therapeutics;Nutrient;nutrient deprivation;oxidation;Pathologic;Pathology;Pathway interactions;perilipin;persulfides;Phosphorylation;Phosphorylation Site;Physiological;Play;Post-Translational Protein Processing;pressure;Process;Production;protein expression;protein function;Proteins;recruit;Regulation;Reporting;response;Role;Serine;Signal Pathway;Signaling Molecule;Stimulus;Stress;sulfhydration;Testing

PROJECT_TITLE: Regulation of CSE-Derived Hydrogen Sulfide in the Heart

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Immunotherapy;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: SEATTLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE In recent years, the integration of electrochemical biosensors with microelectronics has opened the avenue for miniaturized, low-cost systems that integrate biomolecular sensing with digital computing, programming, and communication. Here we propose to integrate electrochemical aptamer-based sensors (“aptasensors”) into a microfluidic multi-well platform to enable the recording of cell death and cytokine secretion data from human, intact tumor biopsies in a multiplexed, parallelized format.

PI_NAMEs: FOLCH, ALBERT  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Aftercare;Animals;anti-PD-1;Antineoplastic Agents;Antitumor Drug Screening Assays;aptamer;Architecture;Biological Assay;Biological Models;Biopsy;Biosensor;cancer cell;Cancer Patient;Cell Culture Techniques;Cell Death;Cell Death Induction;Cells;checkpoint inhibition;checkpoint modulation;chemotherapy;Clinical Trials;colon cancer patients;Colorectal Cancer;Combination immunotherapy;Combined Modality Therapy;Communication;Complement;Computer Models;cost;cytochrome c;cytokine;Data;Data Collection;Development;Devices;digital;digital computing;Dissociation;Drug Combinations;drug development;Drug Evaluation;Drug resistance;Drug Screening;Drug Targeting;drug testing;efficacy testing;Failure;Genomics;Hour;Human;human data;human tissue;Image;Immune;Immune checkpoint inhibitor;Immunotherapy;Inflammatory;insight;Interferon Type II;kinase inhibitor;Machine Learning;Malignant Neoplasms;Marketing;MC38;Mechanics;Metastatic Neoplasm to the Liver;meter;Methodology;microelectronics;Microfluidic Microchips;Microfluidics;miniaturize;Molecular;Monitor;mouse model;Mus;Neoplasm Metastasis;Oncology;Optics;organ on a chip;Organoids;parallelization;Pathway interactions;Patients;Periodicals;personalized medicine;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phosphotransferases;Play;precision oncology;predictive marker;preservation;Price;Process;Protein Array;protein kinase inhibitor;Proteins;response;Role;safety testing;Sampling;screening;sensor;Shapes;Solid Neoplasm;System;Techniques;Technology;Testing;Three-Dimensional Imaging;Time;Tissues;TNF gene;treatment response;tumor;tumor heterogeneity;tumor microenvironment;Tumor Tissue;user-friendly;Vascular Endothelium;virtual;Work

PROJECT_TITLE: Multiplexed drug testing of micro-dissected tumors using a microfluidic platform with integrated electrochemical aptasensors

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Rural Health;Social Determinants of Health

PI_NAMEs: COMELLAS, ALEJANDRO PIERRE (contact)

PROJECT_TERMS: Address;Air Pollutants;Animal Model;Animals;Area;Basic Science;Behavior;behavior influence;Biological;Biometry;Blood Vessels;Cardiopulmonary Physiology;career;Clinical;Clinical Investigator;Clinical Research;Clinical Research Associate;Clinical Treatment;community engagement;community organizations;community partnership;computer scientist;Core Facility;Data Analyses;data to knowledge;design;Disease;Doctor of Philosophy;Ecological momentary assessment;Ensure;Environment;Environmental Exposure;Environmental Health;Evaluation;experience;Exposure to;Faculty;Family suidae;Fellowship;Goals;handheld mobile device;Health;health literacy;health science research;Health Sciences;Human;human subject;Image;imaging facilities;Infrastructure;insight;interdisciplinary collaboration;interest;Iowa;Lung;lung injury;member;Monitor;National Institute of Environmental Health Sciences;Pathway interactions;Phenotype;Physiological;Population;population health;Predisposition;Process;professor;Public Health;Public Health Practice;public health research;Pulmonary function tests;Pulmonology;radiological imaging;Radiology Specialty;recruit;Reproducibility;Research;Research Design;Research Personnel;research study;Research Subjects;Research Support;research vision;Resources;Respiratory Function Tests;response;Rodent;Rural;Safety;Sampling;Science;Strategic Planning;Structure;Symptoms;Technology;Testing;Time;Tissues;Toxic effect;Training and Infrastructure;Translating;Translational Research;translational study;Translations;Universities

PROJECT_TITLE: Integrated Health Sciences Facility Core


NIH_SPENDING_CATS: Bioengineering;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: O'SHAUGHNESSY, PATRICK T (contact)

PROJECT_TERMS: Address;Aerosols;Affect;Agriculture;Air;Air Pollutants;air sampling;Analytical Chemistry;analytical method;Area;Blood specimen;Budgets;career;Cells;Chemicals;Clinical Treatment;Collection;Complex;Complex Mixtures;Consultations;cost effective;data management;Deposition;design;Doctor of Philosophy;Engineering;Environment;Environmental Exposure;Environmental Health;Environmental Pollutants;environmental stressor;epidemiology study;Equipment;experimental study;exposure route;Exposure to;Extramural Activities;Faculty;Food;fundamental research;Funding;Gases;Goals;Grant;Health;health literacy;Health Physics;health science research;Human;Individual;Industrial Health;instrument;instrumentation;Interdisciplinary Study;Investigation;Iowa;Laboratories;Leadership;Link;Liquid substance;Lung;Measurement;Measures;Mechanics;member;Mentors;Methods;Midwestern United States;Mission;Modeling;Modernization;National Institute of Environmental Health Sciences;Outcome;Oxidation-Reduction;particle;Pilot Projects;Policies;pollutant;Population;population health;Population Study;Postdoctoral Fellow;pre-doctoral;professor;Public Health Practice;quality assurance;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;Risk;Role;Rural;rural dwellers;Rural Health;Sampling;Science;Services;Spatial Distribution;Specialist;System;Techniques;Tissue Sample;Tissues;Toxicology;Training;Translating;Universities;vapor;Water;Work

PROJECT_TITLE: Exposure Science Facility


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Rural Health;Social Determinants of Health

PI_NAMEs: THORNE, PETER S (contact)

PROJECT_TERMS: Address;Adopted;adverse outcome;Aerosols;Air;Air Pollutants;Airborne Particulate Matter;Allergens;Animal Model;Area;Articulation;Asthma;Biochemistry;Biological;Biological Assay;Biological Markers;Biology;Breathing;career;Cells;Cessation of life;Charge;Chemicals;Chronic Obstructive Pulmonary Disease;Cohort Studies;data management;Dedications;design;Doctor of Philosophy;Dose;Endotoxins;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Health;epidemiology study;Equipment;Exposure to;Face;facility renovation;Faculty;Farm;Funding;Gastrointestinal tract structure;Glucans;Goals;Grant;hazard;Hazardous Chemicals;Health;health science research;Human;Immunotoxicology;In Vitro;in vivo;Infrastructure;Inhalation;Inhalation Exposure;Inhalation Therapy;Inhalation Toxicology;innovation;Institution;instrumentation;Investigation;Knowledge;Laboratory Animals;Liquid substance;Lung;Lung Diseases;Maps;meetings;member;Metagenomics;Metals;Methodology;Methods;microbial community;microorganism;mid-career faculty;Modernization;Molecular;nanoengineering;nanomaterials;National Institute of Environmental Health Sciences;novel;Organ;Organism;Outcome;Pathway interactions;Pattern;Persons;Physiological;Play;pollutant;Postdoctoral Fellow;pre-doctoral;Predisposition;premature;Productivity;professor;programs;Property;quality assurance;Reagent;Research;Research Personnel;Resources;response;Role;Rural;rural environment;Science;Scientist;Services;Skin;Specialist;Strategic Planning;Surface;System;Testing;Toxic effect;toxicant;Toxicology;Training;vaping;Virus;Wages;Welding;Work;Xenobiotics

PROJECT_TITLE: Pulmonary Toxicology Facility


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Cerebrovascular;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: We hypothesize that older subjects with COVID-19, in particular those with new post-COVID subjective or objective cognitive abnormalities, will have increased plasma and radiographic AD/ADRD biomarkers, and a greater likelihood of abnormal cognitive testing and progression to Alzheimer’s disease or related dementias over time. Our proposed studies will elucidate predisposing risk factors and biomarkers for COVID-related cognitive abnormalities, provide mechanistic insights into underlying pathogenesis, and provide data on long- term outcomes, including the development of AD/ADRD-related disorders.

PI_NAMEs: FRONTERA, JENNIFER ANN;GE, YULIN ;WISNIEWSKI, THOMAS M (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: 2019-nCoV;Age;age related neurodegeneration;aged;aging related;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;Atrophic;Biological Markers;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood-brain barrier disruption;brain fog;brain volume;Cerebrovascular Circulation;Cerebrum;Clinical;Clinical dementia rating scale;Clinical Trials;Cognition;Cognitive;cognitive performance;cognitive testing;COVID-19;COVID-19 neurocognitive sequelae;COVID-19 pandemic;COVID-19 patient;COVID-19 severity;Data;Data Set;dementia risk;Development;Disease;Down-Regulation;Encephalopathies;endothelial dysfunction;Enrollment;Enzymes;Exclusion;Ferritin;FGF2 gene;Fibrin fragment D;functional decline;Glial Fibrillary Acidic Protein;Grant;Hemorrhage;high risk;Hospitalization;Hospitals;Hypoxia;Image;Impaired cognition;indexing;Individual;Infection;Inflammation;Inflammatory;inflammatory marker;Injury;insight;Interferon Type II;Interleukin-6;Interleukins;Intervention;Laboratories;Light;Link;Magnetic Resonance Imaging;Measures;Metabolic Brain Diseases;metabolic rate;Nerve Degeneration;Nervous System Disorder;Neurobehavioral Manifestations;neurofilament;neuroimaging marker;neuroinflammation;Neurologic;Neuropsychology;neurovascular injury;novel;Older Population;Outcome;Oxygen;Pathogenesis;Pathology;Pathway interactions;Patients;Plasma;Population;Populations at Risk;post SARS-CoV-2 infection;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID-19;Prevention strategy;primary outcome;Prospective Studies;radiological imaging;Recording of previous events;response;Risk;Risk Factors;SARS-CoV-2 infection;SARS-CoV-2 negative;SARS-CoV-2 positive;secondary outcome;Sum;Symptoms;targeted treatment;tau Proteins;tau-1;Telephone;Testing;Time;TNF gene;UCHL1 gene;Up-Regulation;Vascular Endothelial Growth Factor D;Viral;white matter injury;Work

PROJECT_TITLE: Alzheimer’s Disease Related Biomarkers following SARS-CoV-2 Infection

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: JANSSEN, BRANDI  (contact)

PROJECT_TERMS: Address;Agriculture;Agrochemicals;Allergens;Awareness;behavioral health;career;Chronic Disease;Clinical;clinical care;Collaborations;Communication;Communities;community engaged approach;community engagement;Community Health;Complex;Decision Making;Doctor of Philosophy;drug resistant pathogen;Dust;Economics;Ensure;Environmental Hazards;Environmental Health;environmental justice;Equity;Event;experience;Exposure to;Faculty;Fellowship;Geography;Goals;Grant;Health;health disparity;health empowerment;health knowledge;health literacy;Health Professional;Health protection;Health Resources;health science research;holistic approach;improved;Industry;Infrastructure;innovation;Knowledge;Livestock;member;Mentors;Mentorship;Methods;Midwestern United States;Modeling;Multimedia;multimodality;organizational structure;Pesticides;Policy Maker;Politics;Poverty;Preventive care;Production;programs;Public Health;Research;Research Personnel;Resources;Role;Rural;Rural Community;rural dwellers;Rural Health;rural health disparities;Science;Scientist;Series;skills;social;Social Sciences;Strategic vision;Structure;success;Training;training opportunity;Translating;Translational Research;Translations;Trust;water quality;Work

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Infectious Diseases;Inflammatory Bowel Disease

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the regulation of the intestinal epithelial cell’s ability to secret antimicrobial peptides and protect itself from invasion by bacteria in health and diseases such as exposures to enteropathogens and inflammatory bowel disease plays a central role in defense of the body. The proposed studies are relevant to the mission of the NIDDK because they are expected to show a role for carcinoembryonic antigen cell adhesion molecule 1 in these processes and provide a tractable means to enhance the protection of the intestinal epithelium and thus the host from diseases involving intestinal bacteria.

PI_NAMEs: BLUMBERG, RICHARD S (contact);BLUMBERG, YU-HWA HUANG

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Address;Affinity;Alternative Splicing;Animal Model;anti-microbial peptide;Apical;Bacteria;Bacterial Translocation;Binding;Binding Sites;Biophysics;Carcinoembryonic Antigen;Catalogs;CEACAM1;Cell Adhesion Molecules;cell type;Colitis;commensal microbes;conditional knockout;Coupled;Cytoplasmic Tail;Data;Defense Mechanisms;dextran sulfate sodium induced colitis;Disease;Distal;Down-Regulation;enteric pathogen;Epithelial Cells;Epithelium;Exhibits;Exposure to;Face;Family;gain of function;Generations;Goals;gut inflammation;Health;Homodimerization;Human;Human Characteristics;humanized mouse;Immune;Immunoglobulins;In Vitro;in vivo;Infection;Inflammatory Bowel Diseases;insight;Integral Membrane Protein;intestinal epithelium;Intestines;Invaded;knockout animal;Lactobacillus brevis;Ligand Binding;Ligands;Ligation;Light;Link;Listeria monocytogenes;Lymphocyte;Mediating;member;Membrane;Microbe;microbial;Mission;mouse model;Mucous Membrane;Mus;mutant;Myeloid Cells;N Domain;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Outcome;pathogenic microbe;pharmacologic;Play;Population;Predisposition;Process;Production;Property;Protein Isoforms;Public Health;Regulation;Research;Research Proposals;response;Role;sensor;Signal Transduction;Site;Source;Surface;System;Testing;Therapeutic;therapeutic protein;Time;Variant

PROJECT_TITLE: Regulation of Mucosal Lymphocytes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-Y(04)]


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: STONE, ELIZABETH  (contact)

PROJECT_TERMS: Applications Grants;Area;Award;career;career development;Career Mobility;community engagement;Core Facility;cost;Development;Discipline;Environmental Health;Fostering;Funding;Grant;health science research;innovation;interdisciplinary collaboration;Investments;Iowa;member;Mission;National Institute of Environmental Health Sciences;outreach;Pilot Projects;Process;Program Development;programs;Recording of previous events;recruit;Request for Applications;Research;Research Personnel;Scientific Advances and Accomplishments;Services;Study Section;Talents;Training;Universities;Work

PROJECT_TITLE: Pilot Grant Program


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Orphan Drug;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE The life-threatening diseases Brugada Syndrome and Arrhythmogenic Cardiomyopathy are associated with mutations in proteins with high expression in the intercalated disc: for example, sodium channels and plakoglobin, respectively. Despite that these mutations are thought to be functionally expressed throughout an organism’s lifetime, the disease can be “concealed,” and specifically, patients do not always exhibit a diagnostic ECG, which suggests that mechanisms for treating the disease are in fact tied to the mechanisms that conceal the disease. We hypothesize that a form of cell-to-cell coupling, called ephaptic coupling, can conceal the disease independent of sodium channel or structural protein remodeling, and promoting ephaptic coupling should reduce the risk of lethal arrhythmias in patients with these disease-causing mutations.

PI_NAMEs: POELZING, STEVEN  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Acute;Adhesions;Affect;Animal Model;Area;Arrhythmia;arrhythmogenic cardiomyopathy;Biophysics;Blood Substitutes;Brugada syndrome;Cardiac;Cardiovascular Diseases;Cell Adhesion Molecules;Cell Communication;Cells;clinically relevant;Collaborations;Communication;Connexin 43;Connexins;Conscious;Coupling;Data;Defibrillators;Dependence;desmoplakin;Desmosomes;Diagnostic;Disease;disease-causing mutation;Early Diagnosis;Edema;Electrocardiogram;Electrolytes;Etiology;Exhibits;experimental study;extracellular;force sensor;Functional disorder;functional loss;Gap Junctions;Gene Modified;gene therapy;Genes;Heart;Heart Diseases;human induced pluripotent stem cells;in vivo;induced pluripotent stem cell derived cardiomyocytes;Injections;innovation;Intercalated disc;intercellular communication;interstitial;Investigation;Ions;Knock-out;Laboratories;Left;Left ventricular structure;Life;Link;loss of function;loss of function mutation;Mannitol;Maps;Masks;Measures;Mechanics;Methods;Modeling;mouse model;Mus;Mutation;N-Cadherin;nano;Nature;novel;novel therapeutics;oculodentodigital dysplasia;Optics;Organism;Osmosis;patch clamp;Pathogenesis;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Peptides;pharmacologic;Phenotype;plakoglobin;prevent;protein expression;Protein Isoforms;Proteins;Reporting;response;Right ventricular structure;Risk Reduction;Secondary to;Sodium Channel;Stress;Structural Protein;Structure;Sudden Death;superresolution microscopy;Syndrome;Tail;Testing;therapeutic target;therapeutically effective;Tissues;Transmission Electron Microscopy;Veins;Ventricular;Ventricular Arrhythmia;voltage;Wild Type Mouse;Work

PROJECT_TITLE: Arrhythmia Mechanisms Modulated by Intercalated Disc Extracellular Nanodomains

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Genetic variation impacts gene expression via complex gene regulatory mechanisms that  involve enhancer activation and chromatin folding. However, how genetic variation influences  enhancer activity and chromatin folding has not been fully understood in the developing human  cortex. The work proposed in this application will help delineate genetic influences on enhancer  activity and chromatin folding during human cortical development, which will improve our  understanding of regulatory mechanisms impacting human brain development and risk for  neuropsychiatric disorders.

PI_NAMEs: STEIN, JASON LOUIS (contact);WON, HYEJUNG

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: 3-Dimensional;Adult;Alleles;Architecture;Autopsy;Bar Codes;Biological Assay;Brain;brain tissue;causal variant;Cell Nucleus;cell type;Chromatin;Chromosomes;Complex;Development;Disease;DNA;Enhancers;fetal;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide;Genotype;Haplotypes;Heterozygote;Histone Acetylation;Histone Fold;Histones;Human;Imaging Techniques;improved;In Vitro;Individual;Knowledge;Label;Location;Measures;Mental disorders;Methods;Molecular;nerve stem cell;neurodevelopment;Neuronal Differentiation;neuropsychiatric disorder;novel;Oligonucleotides;Paint;Pathogenesis;Population;Process;Quantitative Trait Loci;Regulatory Element;Reporter;Risk;risk variant;Sorting;Specificity;Stimulus;Techniques;Technology;Time;Tissue Donors;Tissues;Transcript;transcriptomic profiling;transcriptomics;Untranslated RNA;Validation;Variant;Visualization;Work

PROJECT_TITLE: Discovery and validation of genetic variation impacting the gene regulatory landscape during human cortical development


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: 8. Narrative We propose testing Adapt2Quit — an innovative motivational texting “recommender system.” Adapt2Quit enhances tailored motivational messaging systems using machine-learning algorithms to learn from, and adapt to, user feedback (prior and daily message ratings), thereby increasing message personal relevance. Our study will test Adapt2Quit motivational messaging texting with socioeconomically disadvantaged (SED) smokers.

PI_NAMEs: SADASIVAM, RAJANI  (contact)

PROGRAM_OFFICER_NAME: CICCOLO, JOSEPH THOMAS

PROJECT_TERMS: active control;Address;Adopted;Award;behavior change;Behavior Therapy;Behavioral;Belief;Biochemical;Collaborations;Competence;Complex;Computers;Data;design;digital health;Economically Deprived Population;Effectiveness;effectiveness evaluation;Engineering;Evaluation;evidence base;experimental study;Feedback;Frequencies;Funding;Goals;Health;health care settings;health disparity;Healthcare;Heterogeneity;high risk population;improved;Individual;innovation;Intervention;Interview;Lead;Learning;learning progression;Machine Learning;machine learning algorithm;Measures;Mediating;Mediation;Motivation;multidisciplinary;nicotine replacement;Odds Ratio;Pamphlets;Paper;Pattern;Prevalence;primary outcome;Process;quitline;Randomized;Readiness;recruit;rural healthcare;secondary outcome;Self Determination;Self Efficacy;Site;Smoke;Smoker;Smoking;Smoking and Health Research;smoking cessation;smoking-related disease;socioeconomic disadvantage;System;tailored text messaging;Target Populations;Testing;Text Messaging;theories;Time;Urban Health

PROJECT_TITLE: Adapt2Quit – A Machine-Learning, Adaptive Motivational System: RCT for Socio-Economically Disadvantaged smokers”

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: NS

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative This project aims to record the activity of every cell in the brains of many individual worms (C. elegans) throughout development and in a variety of contexts. This will provide insight into how brains develop in growing animals, and how brains of genetically identical individuals can have divergent activity patterns over this period of development.

PI_NAMEs: VENKATACHALAM, VIVEK  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Adult;Affect;Age;Animal Behavior;Animals;Behavior;behavior prediction;Biological Models;Brain;Brain imaging;Caenorhabditis elegans;Calcium;cell type;Cells;Chemicals;Collection;computerized tools;connectome;Cues;Development;expectation;Funding;Gene Expression;Genetic;Goals;hatching;Housing;Human;Image;Individual;individual variation;insight;inter-individual variation;Larva;Learning;lithography;Maps;Measurement;Measures;Microfluidic Microchips;Microfluidics;Modeling;Molting;Motor Neurons;National Institute of Neurological Disorders and Stroke;Neurons;Newborn Infant;nutrition;Optics;Output;Pattern;Process;reproductive;Resolution;response;Sensory;Series;Stimulus;Structure;Synapses;System;Techniques;tool;Touch sensation;Work;young adult

PROJECT_TITLE: Development and Divergence of Whole-Brain Activity


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CLEVELAND

ORG_DEPT: CHEMISTRY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Narrative  Multiple distinct epigenetic pathways collaboratively regulate gene expression and play key roles in various biological processes and human diseases. However, the functional interplays between these epigenetic mechanisms remain elusive due to the lack of tools to dissect their relationships. This proposal is to establish a comprehensive toolset that enables the simultaneous but independent control multiple epigenetic mechanisms at defined genome locations. This new toolkit will allow the interrogation of crosstalk between distinct epigenetic pathways and the consequences on gene activities. We expect the results from this research will advance our understanding of gene regulation and lead to the development of new therapeutic strategies for human diseases.

PI_NAMEs: LIANG, FU-SEN  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Adaptor Signaling Protein;Address;base editing;Biological Process;Chemicals;chromatin remodeling;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Complex;Development;Disease;DNA Methylation;effectiveness testing;Engineering;Epigenetic Process;epigenetic regulation;epigenome;epigenome editing;Foundations;Future;Gene Expression;Gene Expression Regulation;Genes;Genome;genomic locus;Goals;Guide RNA;Heterodimerization;histone modification;Histones;human disease;Individual;innovative technologies;Location;Methods;Mutation;novel therapeutic intervention;Nucleosomes;Pathogenesis;Pathway interactions;Play;Proteins;recruit;Research;Research Personnel;Role;Shapes;spatiotemporal;Specificity;System;Technology;Time;tool;Variant;Work;Writing

PROJECT_TITLE: "Developing A Comprehensive Toolkit for Chemical Inducible Epigenome Remodeling"

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative The CTSA K12 Program at the University of Michigan will build upon its history of innovative and impactful clinical and translational career development programs by providing new programmatic initiatives to support institutional transformation regarding the often invisible but pervasive patterns that disproportionately alter careers those underrepresented in their fields (i.e., the hidden curriculum). These efforts will also allow us to continue MICHR's legacy of building strong leaders within diverse research scientific communities that impact human health, ranging from basic drug and genomic discovery to policy research addressing health disparities and the opioid crisis.

PI_NAMEs: ELLINGROD, VICKI L (contact);ROBINSON, LEAH ELIZABETH

PROGRAM_OFFICER_NAME: LEYVA, FRANCISCO

PROJECT_TERMS: Acceleration;Address;Advocate;Area;career;career development;Clinical;Clinical Research;Communities;Competency-Based Education;Educational Curriculum;Evaluation;Extramural Activities;Faculty;Feedback;Fortification;Funding;Genomics;Health;health disparity;Human;Influentials;innovation;Institution;Lead;Mentored Clinical Scientist Development Program;Mentors;Michigan;multidisciplinary;opioid epidemic;Outcome;Paper;Pattern;Pharmaceutical Preparations;Policies;Policy Research;Postdoctoral Fellow;Preparation;Program Development;programs;Research;Research Project Grants;Research Support;Research Training;Science;Scientist;Secure;social media;Social Network;success;Time;Training;Translational Research;translational research program;Translations;Universities;Work


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Nanotechnology;Women's Health Research

ORG_CITY: MADISON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative This proposed research is relevant to public health because triple-negative breast cancer (TNBC) is the most lethal breast cancer with limited treatment options. The goal is to develop nano-formulations based on oligo(lactic acid)n-prodrugs, based on paclitaxel, rapamycin (mTOR) and selumetinib (MEK), focusing on scale-up of GMP- grade material, physicochemical properties, toxicity, pharmacokinetics and biodistribution and evaluation in murine tumor models of TNBC. Nano-formulations based on oligo(lactic acid)n-prodrugs, safely injected as 2- or 3-drug combinations, will prolong, elevate and overlap tumor exposure and potentially exceed antitumor efficacy of standard-of-care (Taxol), oral everolimus and oral selumetinib, which have been tested in clinical trials.

PI_NAMEs: KWON, GLEN S. (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: 4T1;Adverse effects;Area;Biocompatible Materials;Biodistribution;Blood;Blood Chemical Analysis;Body Weights and Measures;Breast Cancer Model;Breast Cancer therapy;Cancer Intervention;chemotherapy;Clinical;Clinical effectiveness;Clinical Trials;Combined Modality Therapy;Coupled;Disease;Dose;Dose Limiting;Drug Combinations;Drug Delivery Systems;Drug Kinetics;druggable target;Effectiveness;ethylene glycol;Evaluation;Exhibits;Female;FRAP1 gene;Goals;Hemangiosarcoma;Histopathology;Hour;Immunocompetent;Immunomodulators;immunoregulation;improved;in vivo;Inbred BALB C Mice;inhibitor;Injections;Lactic acid;Liquid Chromatography;male;Malignant Breast Neoplasm;MAP Kinase Gene;Mass Spectrum Analysis;Measures;MEKs;Methods;Micelles;Microtubules;Modeling;Molecular Weight;mouse model;mTOR Inhibitor;Mus;nanoformulation;nanomedicine;nanomicelles;Nanotechnology;Nature;novel;Oligonucleotides;Oral;Organ;Orphan Drugs;Outcome;Paclitaxel;Pathway interactions;Patient Selection;Pharmaceutical Preparations;Pharmacology;PI3K/AKT;Plasma;Prodrugs;Property;Public Health;ratiometric;Research;Rodent;Safety;scale up;SDZ RAD;Signal Transduction;Signal Transduction Inhibitor;Sirolimus;Solubility;Sprague-Dawley Rats;standard of care;targeted treatment;Testing;Time;Toxic effect;triple-negative invasive breast carcinoma;tumor;tumor growth

PROJECT_TITLE: Oligo(lactic acid)n-Prodrug Nanomedicines for Combination Therapy


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

ORG_STATE: PA

PHR: The purpose of this proposal is to summarize the resources at Magee-Womens Hospital and the University of Pittsburgh and to demonstrate how we will continue to contribute meaningfully to the mission and objectives of the NICHD-sponsored Maternal-Fetal Medicine Units Network. We are enthusiastic about contributing to the success of the MFMU Network and its continued pre- eminence in clinical research.

PI_NAMEs: SIMHAN, HYAGRIV N (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;adverse pregnancy outcome;Area;base;Biological;Clinical;clinical center;clinical practice;Clinical Research;clinical research site;Collaborations;Collection;Data;Demography;design;Discipline of obstetrics;Enrollment;Epidemiology;experience;Faculty;fetal;First Pregnancy Trimester;follow-up;Genomics;Gynecology;high risk;Hospitals;Image;Individual;Infrastructure;Institution;Intervention;Lactation;Maternal-Fetal Medicine Units Network;Mission;Multi-Institutional Clinical Trial;Multicenter Studies;multidisciplinary;National Institute of Child Health and Human Development;Neonatal;Newborn Infant;Observational Study;Obstetric pharmacology;Pathology;patient population;Patients;Perinatal;Persons;Placenta;Population;postnatal;Pregnancy;pregnant;Premature Birth;Prenatal care;Proteomics;Protocols documentation;Randomized;Recording of previous events;Reproducibility;Reproductive Sciences;Research;Research Infrastructure;Resources;Sampling;Site;Structure;success;System;Technical Expertise;ultrasound;Universities;Woman;Work

PROJECT_TITLE: Maternal-Fetal Medicine Unit (MFMU) Network Clinical Centers