ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Narrative We have discovered a molecule from the microbiome that enhances checkpoint blocking therapy in 2 experimental models of cancer. This molecule is a glycolipid that is found on anaerobic gram-negative bacteria that live in the intestine and is a tetraacylated monophosphorylated analog of lipid A (4A1P-MPLA). Using a synthetic form of 4A1P-MPLA that enhances regulatory T cells in the gut, we will determine mechanisms of action and breath of therapeutic targets.

PI_NAMEs: KASPER, DENNIS L. (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: Acylation;Address;Adenocarcinoma;Affect;analog;anti-PD-L1 therapy;anti-tumor immune response;Antibiotics;Antitumor Response;B-Lymphocytes;Bacteria;Bacteroides;Breast Carcinoma;cancer immunotherapy;Cancer Model;Cancer Patient;cancer type;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Compartmentation;Cell surface;cell type;Cells;checkpoint therapy;Clinical;clinical application;Collaborations;Colon;Colon Adenocarcinoma;commensal bacteria;comparison control;Data;Dedications;Dendritic Cells;Development;Dose;draining lymph node;Eligibility Determination;Enhancers;Escherichia coli;Exhibits;Experimental Models;FDA approved;fighting;Flow Cytometry;Frequencies;Gammaproteobacteria;Gene Modified;Genetic Transcription;germ free condition;Germ-Free;Glycolipids;Gnotobiotic;Goals;Gram-Negative Anaerobic Bacteria;granulocyte;gut microbiome;gut microbiota;Human;Immune;Immune checkpoint inhibitor;Immune response;Immune system;immunogenicity;Immunological Models;Immunologics;Implant;improved;In Vitro;Industrialization;Intestines;Isomerism;Laboratories;Lamina Propria;Lipid A;lipooligosaccharide;Literature;Location;Macrophage;Malignant Neoplasms;MC38;medical schools;Melanoma;Melanoma Tumor;Membrane;mesenteric lymph node;Microbe;microbiome;Modeling;monocyte;Mus;Myeloid Cells;Myeloid-derived suppressor cells;Natural Killer Cells;novel therapeutics;Oral;Organism;Pathway interactions;patient response;Patients;PD-1 pathway;Pentas;Peripheral;Phenotype;Population;programmed cell death ligand 1;Publishing;Regulatory T-Lymphocyte;response;restraint;Signal Pathway;Signal Transduction;Structure;subcutaneous;success;Surface;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;therapeutic target;therapy outcome;Tissues;tumor;tumor growth;Tumor Immunity;tumor microenvironment

PROJECT_TITLE: Tetraacylated lipid A enhancement of checkpoint blocking cancer immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 TIO-D (01)]


ADMINISTERING_IC: DE

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Public Health Relevance Statement. Approximately 1-in-15 community-dwelling adults over 50 years old are formerly incarcerated, and incarceration history places this population at increased risk for chronic and geriatric disease. We will leverage data from the Health and Retirement Study to conduct the first comprehensive study of the impact of incarceration on oral health and dental care among older adults.

PI_NAMEs: TESTA, ALEXANDER MICHAEL (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Acceleration;Address;Adolescent and Young Adult;Adult;Age;Alcohol consumption;American;care systems;Characteristics;Chronic;Chronic Disease;Communities;Data Set;Dental;Dental Care;Dental Care for Aged;Dental caries;Disease;Economically Deprived Population;edentulism;Elderly;ethnic minority;Ethnic Origin;evidence base;Exhibits;experience;food insecurity;Fostering;Health;Health and Retirement Study;Health behavior;health data;health disparity;health inequalities;Health Status;Healthcare;Healthcare Systems;High Prevalence;human old age (65+);Imprisonment;improved;Individual;Intervention;Investigation;Investments;Lead;Life;Life Cycle Stages;Literature;low socioeconomic status;Measures;Mediating;Minority Groups;National Institute of Dental and Craniofacial Research;Nature;older adult;Older Population;Oral health;Outcome;Persons;Population;Preventive dental care;Prisons;public health relevance;Race;racial minority;Recording of previous events;Research;Risk;Risk Factors;Smoking;Social Network;socioeconomic disadvantage;Socioeconomic Factors;Socioeconomic Status;socioeconomics;Stressful Event;Syndrome;Time;Translational Research;United States;Variant;Vulnerable Populations

PROJECT_TITLE: Oral Health and Dental Care Utilization Among Formerly Incarcerated Older Adults in the United States

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 YM (04)]


ADMINISTERING_IC: DC

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Rehabilitation;Social Determinants of Health

ORG_CITY: CINCINNATI

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE This proposal is relevant to public health because it will provide critical insight into how smartphone- or computer- based software can be used to help transgender people train their voices. Transgender people often wish to modify their voice to match their gender, but voice training administered by experts is expensive and often inaccessible. Our project will thus create and evaluate the first transgender voice training software that combines real-time information about vocal pitch and resonance with structured exercises.

PI_NAMEs: MCALLISTER, TARA ;NOVAK, VESNA DOMINIKA (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Area;Benchmarking;Biofeedback;Biomedical Engineering;Cellular Phone;Characteristics;cis-male;Communication;Communication impairment;Computer Assisted;Computer software;computerized;Computers;Consumption;Control Groups;cost;Data;Development;Digital Signal Processing;Distress;dysphoria;evidence base;Exercise;Exhibits;experience;experimental group;Feedback;Foundations;Frequencies;Future;Gender;gender affirmation;gender diverse;gender dysphoria;Gender Identity;gender minority;General Population;Goals;Grant;Home;improved;improved outcome;Individual;innovative technologies;insight;Instruction;interactive tool;Interview;intrinsic motivation;Laboratories;Language;marginalized population;Measurement;Modification;Motivation;novel;Operative Surgical Procedures;Outcome;Participant;Pathologist;Patient Self-Report;Performance;Persons;primary outcome;Process;Production;prototype;Provider;psychologic;Public Health;Qualifying;Quality of life;Randomized;Randomized, Controlled Trials;remote administration;Remote session;Reporting;research clinical testing;Research Personnel;Sampling;secondary outcome;Self Efficacy;Shame;Signal Transduction;smartphone application;sound;Speech;Statistical Data Interpretation;Structure;Surveys;System;Target Populations;Technology;Testing;Time;tool;Training;transgender;transgender women;usability;virtual;Visual;visual information;Visualization;Visualization software;Voice;Voice Disorders;Voice Training;web based software;Work;Writing

PROJECT_TITLE: Improving the accessibility of transgender voice training with visual-acoustic biofeedback

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE Food insecurity has well-established profound nutritional and public health consequences, including diabetes, obesity, and cardiometabolic disease. The negative physical and mental health consequences of water insecurity are just beginning to emerge but have never been examined among children or adolescents; water insecurity also plausibly exacerbates food insecurity. We will therefore examine the concurrent role of water and food insecurity among US children and adolescents, and measure how they interact to affect sugar-sweetened bev- erage intake and cardiometabolic health.

PI_NAMEs: ROSINGER, ASHER Y. (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: 17 year old;Address;Adolescent;adolescent health;Adult;adult nutrition;Affect;aged;Asian;Attention;Behavior;Beverages;Black race;Body Composition;Body fat;Breast Feeding;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Child;Child Health;climate change;Consumption;cooking;Data;Data Set;Dehydration;Diabetes Mellitus;Disease;Disparity;Eating;Epidemiology;Ethnic Origin;experience;Floods;Food;food insecurity;food quality;Frequencies;Health;health equity;Health Food;Health Status;Health Surveys;Hispanic;Household;Housing;Hydration status;improved;Income;Individual;Inequity;Infrastructure;innovation;insight;Intake;Intervention;Knowledge;Life;Low income;Low Income Population;Measurement;Measures;Mental Health;minority children;mortality;National Health and Nutrition Examination Survey;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;nutrition;Nutrition Surveys;Nutritional;Obesity;Outcome;Overweight;Pathway interactions;Pattern;Personal Satisfaction;physical conditioning;Policies;poor health outcome;Population;Population Growth;Populations at Risk;Poverty;Prediabetes syndrome;Prevalence;Probability;Process;Proxy;Public Health;Race;racial minority;rapid weight gain;Reporting;Research;Resources;Risk;Role;Secure;Severities;Shapes;social;sociodemographic group;structural determinants;sugar;Surveys;sweetened beverage;Testing;trustworthiness;Vulnerable Populations;Water;Water consumption;Weight;Work

PROJECT_TITLE: Quantifying the compounding vulnerabilities of water and food insecurity on child and adolescent health in the US

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


ADMINISTERING_IC: LM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Women's Health Research

ORG_CITY: PISCATAWAY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Life and Death in the Nursery will analyze the emergence of a new subspecialty – neonatology – and the medical technologies employed by neonatologists from the 1960s to the present, centering the experiences of clinicians and parents who met in the NICU as they operated and interacted in the ever- changing world of this new specialty. I will investigate how health care providers and parents experienced the NICU, how it shaped their identity, and what impact their personal position and understanding of neonatology had on their clinical experiences. The book will focus on the impact that changes in medical technologies, reproductive politics, our understanding of disabilities, and attitudes about race had on clinical care and the ways these changes shaped medicine in the NICU, thereby shedding light not only on the history of neonatology, but also pointing to ongoing dilemmas in medicine: decisions about the continuation/ discontinuation of therapies at the edges of life and death, as well as the pervasive existence of health inequities.

PI_NAMEs: SCHOEN, JOHANNA  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: abortion;Academy;Address;Advocate;American;Area;Attention;Attitude;Bioethics;Birth;Books;cancer care;Caring;Cessation of life;Characteristics;Clinical;clinical care;clinical decision-making;Country;Decision Making;Development;disability;Equilibrium;Ethics;Event;experience;Family;Family member;Fetus;General Population;Goals;Health;health inequalities;Health Personnel;Healthcare;History of Medicine;Hospitals;Humanities;Infant;Informed Consent;innovation;insight;Journals;Knowledge;Language;Laws;Leg;Life;Light;Mediation;Medical Ethics;medical specialties;Medical Technology;Medicine;meetings;Movement;Neonatology;Newborn Infant;news;Outcome;Parents;Patient advocacy;Patients;pediatrician;Pediatrics;Politics;Positioning Attribute;Pregnancy;pregnant;Prenatal care;Procedures;Quality of life;Race;Recording of previous events;Reproduction;reproductive;Research;Research Personnel;screening;Shapes;social;Social Medicine;Societies;Technology;technology development;Therapeutic;therapeutic development;Treatment Protocols;Woman;women's reproductive health;Work;Writing

PROJECT_TITLE: Life and Death in the Nursery: A History of Neonatology

STUDY_SECTION_NAME: Special Emphasis Panel[ZLM1 ZH-P (01)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NUTRITION

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Nutrition;Prevention

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: Project Narrative The two-year randomized controlled trial, the CALERIE study, demonstrated that calorie restriction (CR) has the potential to attenuate aging and improve cardiometabolic health in humans. The proposed project is to examine whether CR attenuates mitochondrial DNA heteroplasmic mutations over time in CALERIE participants. The proposed study will provide novel evidence to better understand the molecular underpinnings of the observed effects of CR on aging and cardiometabolic health.

PI_NAMEs: MA, JIANTAO  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Age;age related;Aging;aging biomarker;aging process;aging related;Animal Model;Attenuated;Biological Aging;Biology;Biometry;Blood Chemical Analysis;blood glucose regulation;Blood Pressure;Blood specimen;burden of illness;Caloric Restriction;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Clinical;Code;Complex;Control Groups;Data;design;Development;DNA;DNA Methylation;Energy Intake;Ensure;Genes;Genetic Polymorphism;Genome;gerotherapeutic;Goals;Health;healthspan;heteroplasmy;Human;improved;Inflammation;insight;Lipids;Long-Term Effects;Longevity;Measures;Mediating;Mediation;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial genome;Molecular;Mutation;novel;Nuclear;Obesity;Outcome;Oxidative Phosphorylation;Oxidative Stress;Participant;Pathology;Play;Preventive;Proteins;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;Risk Factors;RNA;Role;Sampling;Single Nucleotide Polymorphism;targeted sequencing;Testing;Time;United States National Institutes of Health;Untranslated RNA;Whole Blood;young adult

PROJECT_TITLE: Calorie Restriction, Mitochondrial DNA Heteroplasmy, Cardiometabolic Profiles, and Biological Aging

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CHAPEL HILL

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative In this collaborative project, we will develop efficient methods for the construction of 18F labeled agents using the tetrazine-trans-cyclooctene ligation. We will develop new 18F labeled trans-cyclooctenes and tetrazines as reporters for large molecule distribution in the CNS. The success of this approach will lead to a comprehensive platform for Positron Emission Tomography (PET) agent preparation and drug distribution mapping.

PI_NAMEs: FOX, JOSEPH M;LI, ZIBO  (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Automation;Binding;Binding Sites;Biological;Biological Availability;Brain;Brain imaging;cancer imaging;Cell Nucleus;Central Nervous System;Chemistry;commercialization;commercialization readiness;Communities;Cyclooctenes;design;Development;drug development;drug discovery;drug distribution;Evaluation;Feedback;Future;hydrophilicity;Hydrophobicity;Image;Imaging Device;improved;In Vitro;in vivo;Kinetics;Label;Ligands;Ligation;lipophilicity;Malignant Neoplasms;Maps;Medical Imaging;Methodology;Methods;nanobodies;Peptides;Permeability;Pharmaceutical Preparations;Positron-Emission Tomography;Preparation;prevent;Procedures;Property;Proteins;Protocols documentation;radiochemical;Radiochemistry;Radiolabeled;rapid technique;Rattus;Reaction;reaction rate;Reporter;Research;scaffold;Site;small molecule;success;technological innovation;Technology;technology validation;tool;Toxic effect;Translations;Variant

PROJECT_TITLE: Development of an Efficient 18F labeling technology based on tetrazine trans-cyclooctene ligation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-C (03)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Pediatric;Recovery Support Services;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE Adolescents with substance use disorders (SUDs) have limited access to developmentally appropriate recovery supports upon discharge from treatment, increasing their risk of relapsing and a cascade of public health consequences. Recovery high schools (RHSs) are one of the few adolescent-focused continuing care options available, providing adolescents with therapeutic and peer recovery supports in an educational setting where all students are committed to maintaining recovery from an SUD. In an effort to dislodge the continuing care barrier and advance the science of recovery support, this project will use a novel dataset and approaches to examine the long-term effects of RHS attendance on recovery outcomes and the mechanisms underlying them, producing the critical knowledge needed to inform the refinement and development of adolescent- focused continuing care and recovery supports.

PI_NAMEs: BERNY, LAUREN MICHELLE (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Address;Adolescent;Adolescent Development;Affect;Aftercare;Area;career;Caring;Chronic;Clinical;Communicable Diseases;cost;Data;Data Analyses;Data Set;design;Development;Disease remission;disease transmission;disorder risk;drinking;Education;educational atmosphere;effectiveness testing;Equity;Evaluation;evidence base;experience;Failure;follow-up;Frequencies;Funding;Goals;Healthcare Systems;high risk;high school;Individual;innovation;insight;Institution;Investments;Knowledge;Life;Literature;long term recovery;Long-Term Effects;Mediating;Mediation;Mentored Research Scientist Development Award;Modeling;National Institute of Drug Abuse;novel;Outcome;Pathway Analysis;peer;peer influence;peer networks;peer recovery;Positioning Attribute;Predisposition;Process;programs;Public Health;Recovery;Recovery Support;Relapse;relapse risk;Reporting;Research;Research Design;Research Personnel;Research Support;return to use;satisfaction;Schools;Science;Scientific Advances and Accomplishments;secondary analysis;social;Social Environment;social influence;Social Network;Socialization;societal costs;Students;substance use;Substance Use Disorder;Telephone;Testing;Therapeutic;treatment duration;treatment effect;Underserved Population;Youth

PROJECT_TITLE: Recovery High Schools as Continuing Care: Long-Term Recovery Effects and Mechanisms of Change

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Kidney Disease

ORG_CITY: CORAL GABLES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE: Over 700,000 Americans live with end-stage kidney disease (ESKD) and 90% percent depend on a functional vascular access for hemodialysis (HD) treatments. Up to 50% of arteriovenous fistulas (AVF), the preferred vascular access for HD, fail to mature after creation (be usable for dialysis) despite improvements in preoperative planning. The research proposed in this application is relevant to public health because it investigates the role of catheter-associated inflammation with failure of the fistula.

PI_NAMEs: MARTINEZ, LAISEL  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Adoptive Transfer;American;Animal Model;Animals;Antimicrobial Effect;Apoptosis;Applications Grants;Arteriovenous fistula;arteriovenous graft;Bacteria;Biological Assay;Blood flow;Blood Vessels;career development;Catheters;Cells;Clinical;Contralateral;Cyclosporine;Data;Death Rate;Development;Dialysis procedure;efficacy testing;End stage renal failure;Epigastric;extracellular;Failure;femoral artery;Fibrosis;Fistula;FPR1 gene;Funding;Funding Opportunities;Future;Genes;Genetically Modified Animals;Goals;Grant;Hemodialysis;high reward;high risk;hospitalization rates;Human;Immune;Immune Sera;Immunohistochemistry;Immunologics;improved;In Vitro;in vivo;infection risk;Infiltration;Inflammation;Inflammatory;Injury;Investigation;Knock-out;knockout animal;Legal patent;Life;Link;Measures;Membrane;Microbial Biofilms;Modeling;modifiable risk;Molecular;Molecular Weight;Morbidity - disease rate;Mus;N-Formylated Peptide;neutrophil;Neutrophil Activation;Neutrophil Infiltration;novel;Operative Surgical Procedures;Outcome;Outcome Study;Pathologic;Pathway interactions;Patients;Pattern;Peptides;Peripheral;Phenotype;Plasma;Population;Postoperative Period;pre-clinical;Production;Productivity;PTPRC gene;Public Health;receptor;Recording of previous events;Research;Research Personnel;response;Risk;Risk Factors;Role;Sepsis;Signal Transduction;single-cell RNA sequencing;Source;Sprague-Dawley Rats;Stenosis;Structure of jugular vein;Study models;systemic inflammatory response;Testing;Thrombosis;Time;Tissues;Transcript;transcriptomics;translational approach;Transplantation;treatment strategy;Up-Regulation;usability;vascular injury;Vascular remodeling;Veins;Venous;Vulnerable Populations

PROJECT_TITLE: Catheter-associated molecular patterns and arteriovenous fistula failure

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: AI

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

ORG_STATE: CA

PHR: Profound sex differences exist in obesity, a growing epidemic in the United States associated with increased risk of infection and allergic disease, yet studies on sexual dimorphic mechanisms underlying these disorders are limited. We propose to investigate the crosstalk between immune and endocrine pathways underlying obesity that influences macrophage- eosinophil interactions, and whether it is regulated by sex hormones and macrophage protein RELMα. Results from this study will delineate previously unknown innate immune pathways that govern sex-specific regulation of obesity and provide novel macrophage effectors that can be targeted to treat obesity and associated co-morbidities.

PI_NAMEs: COSS, DJURDJICA ;NAIR, MEERA GOH (contact)

PROGRAM_OFFICER_NAME: LEITNER, WOLFGANG W

PROJECT_TERMS: Adipose tissue;Adult;Affect;Allergic Disease;Area;Automobile Driving;cell type;Cells;chemokine;Chronic;Coculture Techniques;comorbidity;Data;Diagnosis;Disease;Endocrine;Endocrinology;Environment;eosinophil;Epidemic;estrogen disruption;Estrogens;Experimental Designs;Feedback;Female;Future;Genes;Goals;Gonadal Hormones;Gonadal Steroid Hormones;Grant;Hemoglobin;Heterogeneity;high risk;Hypersensitivity;Immune;immune activation;Immune response;Immune System Diseases;Immunology;Incidence;Infection;infection risk;Inflammation;Inflammatory;Inflammatory Response;innate immune pathways;Innate Immune Response;Investigation;Knockout Mice;Knowledge;Letrozole;Link;Macrophage;male;Mediating;Molecular;multidisciplinary;Mus;Natural Immunity;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;obese person;Obesity;Obesity associated disease;obesity treatment;Operative Surgical Procedures;Ovariectomy;overexpression;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;pharmacologic;pre-clinical;preclinical study;Process;Proteins;Public Health;public health relevance;Publishing;Regulation;Reproductive Endocrinology;response;Risk;SARS-CoV-2 infection;sex;Sex Differences;sexual dimorphism;single cell sequencing;single-cell RNA sequencing;Testing;Tissues;Transcript;transcriptomic profiling;transcriptomics;Transgenic Mice;United States;Untranslated RNA

PROJECT_TITLE: Innate immune pathways underlying sexual dimorphism in obesity pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-M (90)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Chronic Pain;Comparative Effectiveness Research;Complementary and Integrative Health;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Rehabilitation;Precision Medicine;Rehabilitation

ORG_CITY: CHARLESTOWN

ORG_NAME: SPAULDING REHABILITATION HOSPITAL

PHR: Project narrative This project is significant since chronic pain is a major global health problem, a leading cause of disability, with just partially effective treatments associated with major adverse events. Thus, there is a need to develop non-pharmacological, non-invasive, and fully home-based interventions for chronic pain. An alternative is interventions that target the brain plasticity. Our proposal aims to assess the effects of these alternative neuroplasticity-targeted interventions in chronic pain, and to develop models to predict the response to the treatment based on artificial intelligence.

PI_NAMEs: PACHECO, KEVIN  (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: addiction;Adverse event;alternative treatment;Analgesics;analytical method;Anxiety;Area;Artificial Intelligence;Award;Bayesian Network;Behavior Therapy;Biological Markers;Brain;chronic pain;chronic pain management;chronic painful condition;Clinical;clinical practice;Clinical Trials;Combined Modality Therapy;Communities;comparative;comparative efficacy;conditioned pain modulation;cost;COVID-19;Data;Data Aggregation;data fusion;data platform;Data Science;data sharing;Databases;Development;disability;Disease;effective therapy;Effectiveness;efficacy study;Electricity;Electroencephalography;Electromagnetic Energy;Emotional;Esthesia;evidence base;Fostering;Frequencies;Funding;global health;group intervention;Health Care Costs;Heterogeneity;Home;innovation;interpatient variability;Intervention;knowledge integration;knowledge translation;machine learning algorithm;machine learning model;Mental Depression;mental imagery;Meta-Analysis;Methods;Mind-Body Intervention;mind/body;Modality;Modeling;multilevel analysis;multimodal data;multimodality;multiphase optimization strategy;Nature;Neuronal Plasticity;Neuropathy;neurophysiology;neuroregulation;Nociception;Nonpharmacologic Therapy;Pain;Pain management;pain perception;pain reduction;Pain Research;Participant;Pathway interactions;Patients;Persons;Phantom Limb;Population;predicting response;predictive marker;predictive modeling;Protocols documentation;Psychological Techniques;remote intervention;Research;Research Project Grants;responders and non-responders;response;response biomarker;rural area;Safety;Sensory;Social Distance;Source;statistical learning;supervised learning;Surface;Techniques;Testing;Therapeutic;Therapy trial;transcranial direct current stimulation;Translations;Treatment Protocols;treatment response;Underrepresented Populations;United States National Institutes of Health;Universities;Update;web platform

PROJECT_TITLE: Fostering knowledge translation of neuroplasticity-targeted interventions for chronic pain management using advanced meta-analytic methods and statistical learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-Z (90)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Social Determinants of Health

ORG_CITY: MADISON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Low-cost, empirically-supported mental health treatment options are urgently needed for the prison population. This project will provide a pilot test of a self-administered workbook tailored specifically for the prison setting.

PI_NAMEs: KOENIGS, MICHAEL R. (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: acceptability and feasibility;Address;Anger;Anxiety;barrier to care;Behavior;Belief;Caring;Chronic;Clinical;Clinical Trials;Consult;cost;Data;depressive symptoms;design;Development;Effectiveness;effectiveness evaluation;effectiveness trial;effectiveness/implementation design;eligible participant;Ensure;Environment;Exercise;feasibility testing;Feedback;flexibility;Focus Groups;Forensic Medicine;Funding Opportunities;Future;Goals;Group Meetings;Group Therapy;health care availability;Health Services Accessibility;Housing;Imprisonment;Individual;information gathering;Intervention;Language;literacy;Measures;Mediating;meetings;member;men;Mental Depression;Mental disorders;Mental Health;Mental Health Services;mindfulness;National Institute of Mental Health;novel;Outcome;Participant;Persons;Pilot Projects;pilot test;Population;preference;prison population;Prisons;Privacy;Professional counselor;psychologic;Psychology;Randomized;Randomized, Controlled Trials;Reading;recruit;reduce symptoms;Research;Resources;Schedule;Self Administration;self help;Services;Shame;skills;social stigma;Stress;Target Populations;Testing;treatment effect;Trust;Underserved Population;United States;Waiting Lists;Wisconsin;Woman;Writing

PROJECT_TITLE: Pilot effectiveness trial of an ACT self-help workbook tailored specifically for prisons

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Methamphetamine;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: LITTLE ROCK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE New medications are being developed for methamphetamine use disorder (MUD) treatment at a time when treatment options are scant and dropout is high, but clinical trials evaluating new MUD medications are currently limited by only assessing abstinence or urine drug screens as endpoints. Both NIDA and the FDA have recognized abstinence as a high bar for MUD treatment, demonstrating an unmet need for a survey of patient-reported outcomes (PRO) that would expand options for measurable endpoints to address how a patient feels and functions. Since no validated PRO instrument for MUD treatment exists, the proposed study will develop and validate a PRO survey (PROMT, Patient-Reported Outcomes for Methamphetamine Treatment) intended to capture a fuller picture of the therapeutic benefits of medications for MUD and promote the continued development of new treatment products.

PI_NAMEs: PRO, GEORGE  (contact)

PROGRAM_OFFICER_NAME: RAMEY, TANYA S

PROJECT_TERMS: Abstinence;addiction;Address;Affinity;Antibodies;Arkansas;Behavior Therapy;Buprenorphine;buprenorphine treatment;Cities;Client;Clinical;Clinical Trials;cognitive interview;community collaboration;Community Healthcare;community partners;comorbidity;Complement;Country;craving;design;Development;Dropout;drug development;Drug Screening;Drug usage;effectiveness evaluation;Evaluation;experience;Family;Family member;FDA approved;Future;Goals;Harm Reduction;Health;Health Personnel;Healthcare;Healthcare Systems;healthy lifestyle;Heroin;Heroin Dependence;improved;Individual;individualized medicine;Industry;innovation;insight;instrument;Intervention;Interview;Kansas;Measurable;Measures;Medicine;meetings;methadone treatment;Methamphetamine;methamphetamine effect;Methamphetamine overdose;methamphetamine use;Methamphetamine use disorder;methamphetamine user;Mind;Missouri;mortality;National Institute of Drug Abuse;new product development;Opioid;opioid use disorder;Outcome;Outcome Study;Overdose;Patient Outcomes Assessments;Patients;Performance;Persons;Pharmaceutical Preparations;Phase III Clinical Trials;pilot test;Population;pressure;Property;Provider;Psychometrics;Questionnaires;Recovery;recruit;Relapse;Reporting;Research Design;satisfaction;Seminal;side effect;social;Statistical Data Interpretation;stem;Stigmatization;Stress;study population;Suboxone;Substance Use Disorder;success;Surveys;symptomatic improvement;Symptoms;Texas;Therapeutic;therapy development;Time;tool;trial planning;Urine;Validation;Voice;Withdrawal

PROJECT_TITLE: Validation of a survey tool to evaluate patient-reported outcomes for new medications to treat methamphetamine use disorder: The PROMT Survey

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE Parkinson disease (PD) is a progressively disabling neurodegenerative disease that occurs at a frequency of 1- 2 cases per 1,000 population with a prevalence of >2% in persons over 65 years. Genetic insights, namely DNAJC13 p. N855S, now facilitate an accurate and early diagnosis, provide a target and rationale for prevention, and insightful animal models to facilitate development of novel treatments to slow or halt disease progression. This proposal aims to provide mechanistic insight into DNAJC13 p.N855S gene dysfunction characterizing a novel mouse model with respect to its alpha-synuclein and dopaminergic biology, and their relationship with neuroimmune responses in the brain. 1

PI_NAMEs: FARRER, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: accurate diagnosis;Address;Affect;Age;Age Months;alpha synuclein;Anatomy;Animal Model;Autopsy;Autosomal Dominant Parkinsonism;Behavior;Binding;Binding Proteins;Biochemical;Biochemistry;Biological;Biology;Brain;Brain region;Cells;Chronic;Clathrin;Clathrin-Coated Vesicles;Clinical Trials;Cognitive;Color;Communication;Corpus striatum structure;cytokine;Development;Disabling;Disease;Disease Progression;Dopamine;Dopaminergic Cell;dopaminergic neuron;Early Diagnosis;Environment;Equilibrium;Excision;exhaustion;Exocytosis;experimental study;Family;Family member;Freezing;Frequencies;Functional disorder;Future;gain of function;Genes;Genetic;Genetic Research;Heat-Shock Response;High Pressure Liquid Chromatography;Homeostasis;Human;human old age (65+);Immune;Immune response;Immune signaling;Impairment;In Vitro;Induced Mutation;Inflammatory;insight;Interferons;kindred;Knock-in;Label;Lewy Bodies;Lewy Body Disease;Lewy body pathology;Link;Lipids;Mediating;Membrane;Membrane Lipids;Mennonite;Microglia;Midbrain structure;misfolded protein;Missense Mutation;Modeling;Molecular Weight;monomer;Morphology;Motor;motor impairment;mouse model;Mus;mutant;Mutation;Neurodegenerative Disorders;Neuroimmune;neuron loss;Neurons;neurotransmission;Neurotransmitters;novel;novel therapeutic intervention;open field behavior;overexpression;Parkinson Disease;Pathogenesis;Pathologic;patient subsets;Patients;Periodicity;Persons;Phagocytes;Phenotype;Phosphorylation;physiologic model;Physiological;Physiology;Population;pre-formed fibril;Presynaptic Terminals;Prevalence;Prevention;protein aggregation;Proteins;Proteolipids;rare variant;receptor mediated endocytosis;response;reuptake;Role;Scanning;Structure;Substantia nigra structure;Synapses;synaptic depression;Synaptosomes;synuclein;Testing;Therapeutic;tool;trafficking;Tyrosine 3-Monooxygenase;Validation;Vesicle

PROJECT_TITLE: Dnajc13 p.N860S as a physiologic model ofalpha-Synuclein overexpression

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: NEW YORK

ORG_NAME: VA  MEDICAL CENTER

ORG_STATE: NY

PHR: The scientific investigation of this Research Career Scientist is focused on the elucidation of the molecular bases underlying major urinary diseases, in particular bladder cancer and kidney stone. These diseases are extremely prevalent among the Veterans, and are a main reason of high medical expenses, physical and emotional suffering, morbidity, time lost from work and poor quality-of-life. Despite their prevalence and clinical challenges, relatively little is known about how these diseases arise and progress. By identifying the precise molecular events that underpin the disease processes, the Principal Investigator's laboratory has already made several important findings that have significant potential for improving the diagnosis, treatment and prevention of these diseases. The renewal application intends to continue and expand the research activities to further advance our knowledge on these important diseases in order to develop effective management strategies.

PI_NAMEs: WU, XUE-RU  (contact)

PROJECT_TERMS: 9p21.3;Acceleration;accurate diagnosis;Achievement;Acute Renal Failure with Renal Papillary Necrosis;addiction;aerobic glycolysis;Affect;American;Amino Acid Sequence;Angiogenic Factor;anti-cancer research;Appointment;Area;Award;base;Binding;Biological Markers;Bladder;Bladder Control;Bladder Neoplasm;calcification;Calcinosis;calcium phosphate;cancer initiation;career;career development;CDKN2A gene;Cell Cycle Progression;Chromosomes;Chronic Kidney Failure;Clinical;Clinical Management;Collaborations;combinatorial;Communication;Communities;cost;Diagnosis;Disease;disorder prevention;Doctor of Philosophy;Down-Regulation;Education;Emotional;enolase;Enzymes;Etiology;Event;Exhibits;Female;Funding;Genetic;Genetic Engineering;Genetic Transcription;Grant;Growth;Health;Height;Human;Immunotherapy;improved;in vivo;Incidence;Influentials;Institution;interdisciplinary collaboration;Interdisciplinary Study;interstitial;Investigation;Journals;Kidney;Kidney Calculi;Knockout Mice;Knowledge;Laboratories;Limb structure;Link;Long-Term Effects;lost work time;Maintenance;male;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;Medical Care Costs;member;Mentors;Metabolic;Methylation;mid-career faculty;military veteran;Mission;Molecular;molecular subtypes;Morbidity - disease rate;mouse model;multidisciplinary;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;neglect;neoplastic cell;next generation;non-oncogenic;novel;novel therapeutic intervention;novel therapeutics;Nuclear Translocation;Oncogenes;overexpression;Oxygen;Paper;Papillary;Pathogenesis;Patient Care;patient population;Patients;Peer Review;Physiological;Play;Postdoctoral Fellow;Prevalence;prevent;Prevention;Principal Investigator;Process;Productivity;Program Research Project Grants;programs;Protein Isoforms;Proteins;Publishing;Pyruvate Kinase;Quality of life;Recurrence;Reporting;Research;Research Activity;Research Personnel;Research Priority;Research Support;Risk;Role;Scientist;Series;Services;Specimen;STAT3 gene;Techniques;Thick;tool;Training;translational medicine;Translational Research;Transplantation;Tubular formation;Tumor Cell Line;tumor initiation;tumor progression;Tumor Suppressor Proteins;UMOD gene;United States National Institutes of Health;Universities;Untranslated RNA;Up-Regulation;urinary;Urinary tract infection;Urine;urologic;Variant;Veterans;Warburg Effect;Work

PROJECT_TITLE: BLR&D Research Career Scientist Award Application

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 RCSR-N (01)]


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Poverty has long been recognized as an important social determinant of health, and we recently showed that large-scale, government-led cash transfer programs lead to important reductions in mortality among women and young children in low- and middle-income countries. Through this project, we seek to examine pathways that might explain these reductions using national survey data from dozens of low- and middle-income countries. At a time when many countries are considering scaling back or expanding cash transfer programs, this project has the potential to have timely public health and policy impact by producing a comprehensive, global assessment of the causal effects of cash transfers on key child and maternal health outcomes.

PI_NAMEs: RICHTERMAN, AARON G (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: 5 year old;Address;Adult;Adult Children;Adult women;Affect;Age Months;antenatal care;Back;Behavior;Behavioral;behavioral outcome;beneficiary;Birth;Breast Feeding;Caring;Child;Child Health;Child Nutrition;Childhood;combat;Costs and Benefits;Country;COVID-19 pandemic;Data;Data Set;Databases;Death Rate;Demographic and Health Surveys;Diarrhea;Diet;Education;Evaluation;evidence base;food insecurity;Government;Health;Health behavior;health care availability;health care service utilization;Health Promotion;Household;Housing;improved;Individual;interest;Intervention;Lead;Literature;low and middle-income countries;Low Birth Weight Infant;low income country;male;Malnutrition;Maternal Health;Measles;Mediating;Modeling;mortality;neighborhood safety;nutrition;Nutritional status;Occupational;Odds Ratio;Outcome;pandemic disease;Pathway interactions;Personal Satisfaction;Persons;Policies;Policy Maker;Population;Poverty;poverty reduction;Pregnancy;programs;Public Health;Public Policy;Regression Analysis;Reporting;Risk;Risk Adjustment;skills;social health determinants;Social Well-Being;Source;Surveys;Time;Underweight;Vaccination;Variant;Visit;wasting;Woman;Women's mortality;women's outcomes;Work;World Bank

PROJECT_TITLE: The effects of poverty reduction intervention on health outcomes among women and young children in low- and middle-income countries


ORG_CITY: ANN ARBOR

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Colorectal Cancer is one of the most frequently diagnosed and deadliest cancers in both the US and the world. Our preliminary data indicate that AlkBH8, a tRNA methyltransferase, is essential for the growth and tumor forming ability of several colorectal cancer cell lines. We will therefore study the necessity of AlkBH8 in colorectal cancer using cell and animal models and characterize the biochemistry and function of recombinant AlkBH8.

PI_NAMEs: KOUTMOS, MARKOS  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Address;Affinity;Animal Model;Anticodon;Antioxidants;assay development;Binding;Biochemical;Biochemistry;Biological Assay;Biological Process;cancer cell;Cancer Cell Growth;cancer diagnosis;Cancer Etiology;cancer survival;Cell Death;Cell Line;Cell model;Cell Physiology;Cell Survival;Cessation of life;Chemicals;Clinic;Codon Nucleotides;colon cancer cell line;Colon Carcinoma;Colorectal Cancer;Data;deprivation;Detection;Development;Diagnosis;Doxycycline;Drug Metabolic Detoxication;Ensure;Enzymes;Essential Genes;Genes;Genetic Transcription;Glutamic Acid-Specific tRNA;glutathione peroxidase;Goals;Growth;high throughput screening;In Vitro;in vivo;Investigation;Iron;knock-down;Knockout Mice;Knowledge;Label;Laboratories;Lentivirus;liquid chromatography mass spectrometry;loss of function mutation;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Mediating;Medical;Messenger RNA;Methylation;Methyltransferase;Modeling;Modification;Monitor;Mutation;new therapeutic target;novel;Oncogenes;Outcome;Oxidative Phosphorylation;Pathway interactions;patient prognosis;Patients;Phenotype;prevent;Production;prognostic;Proliferating;Proteins;Quantitative Reverse Transcriptase PCR;Radioactive;Reactive Oxygen Species;Recombinants;recruit;resistance gene;Role;screening;Selenium;Selenocysteine;selenoprotein;small hairpin RNA;small molecule inhibitor;solid state;targeted treatment;Terminator Codon;Therapeutically Targetable;Toxic effect;transcriptome sequencing;Transfer RNA;Translations;tRNA Methyltransferases;tumor;Uridine;Western Blotting;Xenograft Model

PROJECT_TITLE: Role of the tRNA methyltransferase AlkBH8 in Colorectal Cancer

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Capillary blood vessels are lined by endothelial cells that are themselves covered by vascular mural cells known as pericytes. Communication between these cells is essential for normal capillary function and, when disrupted, can precipitate disease. Despite their importance, little is known about how pericytes develop. The studies in this proposal seek to understand how pericyte development is controlled during embryogenesis.

PI_NAMEs: LAWSON, NATHAN D (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Anatomy;Basement membrane;Biological Models;Blood capillaries;Blood Vessels;blood-brain barrier function;candidate identification;capillary bed;Cardiovascular system;cell type;Cells;cerebral capillary;Communication;Development;Disease;Embryonic Development;Endothelial Cells;Event;Exhibits;Extravasation;Filtration;Gases;genetic approach;Genetic Enhancer Element;Genetic Transcription;Heterogeneity;Homeostasis;Hormone secretion;Immune;insight;Liver;macromolecule;Molecular;Neurodegenerative Disorders;neuron apoptosis;Neurons;neurovascular;Organ;Organ Specificity;Pericytes;Plasma;Play;prevent;programs;Role;Site;Specific qualifier value;Tissues;trafficking;transcription factor;Zebrafish

PROJECT_TITLE: Developmental origins of pericyte heterogeneity

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (O1)]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Hepatitis;Hepatitis - B;Immunotherapy;Infectious Diseases;Liver Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BOGOTA

ORG_COUNTRY: COLOMBIA

ORG_FIPS: CO

ORG_NAME: PONTIFICIA UNIVERSIDAD JAVERIANA

PHR: PROJECT NARRATIVE These studies are relevant for public health since they focus on the development of novel immune therapies aiming at the cure of a prevalent chronic viral infection (HBV).

PI_NAMEs: PERDOMO, FEDERICO  (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Adoptive Transfer;Alleles;Antigens;antiretroviral therapy;CD8-Positive T-Lymphocytes;Cell Reprogramming;Cells;Chronic;Chronic Hepatitis B;chronic infection;Complex;Cues;cytokine;Development;Disease remission;Effectiveness;Effector Cell;Epitopes;Exhibits;FRAP1 gene;Future;Genetic Transcription;Hepatitis B Virus;Hepatitis C virus;HIV;HIV-1;Human;IL7R gene;immune checkpoint blockade;immune modulating agents;Immunotherapy;improved;In Vitro;Individual;Infection;Infection Control;inhibitor;Maintenance;Mediating;Memory;Metabolic;Metabolic Pathway;Methods;novel;Oximes;Phenotype;Population;Production;programmed cell death protein 1;programs;Proliferating;Property;Public Health;response;Role;Signal Pathway;stem;stemness;System;T cell response;T cell transcription factor 1;Testing;Therapeutic;transcription factor;Viral;Viral Physiology;Viremia;Virus;Virus Diseases

PROJECT_TITLE: CD8+ T CELL REPROGRAMMING TO BOOST ANTIVIRAL POTENTIAL AGAINST CHRONIC INFECTION

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Determining when and what the hippocampus does to support spatial memory and, thereby, healthy independent living remains a major outstanding challenge. This project will study the relevance of rearing, a ubiquitously observed but minimally studied behavior, as a marker of critical hippocampal processing. Through a combination of behavioral analysis, closed-loop optogenetic manipulation and high-density extracellular electrophysiology, this project will establish rearing as a key epoch of hippocampally-dependent spatial memory encoding and determine the relevance of these events on the precision of spatial coding in the hippocampus.

PI_NAMEs: NEWMAN, EHREN L. (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TITLE: Hippocampal-dependent spatial memory encoding during attentive processing from place

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Infectious Diseases;Pain Research;Physical Rehabilitation;Rehabilitation

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: PROJECT NARRATIVE For amputees, directly anchoring a prosthetic device to the bone (as in osseointegrated (OI) prostheses), much more closely matches the physiology and mechanics of a non-amputated limb, resulting in superior outcomes with regards physical function, skin-related complications, chronic pain and osseoperception. However, widespread adoption of OI prostheses to the almost 2 million US patients with limb loss has been limited, to date, by risk for infection given the transcutaneous nature of the implant. In the proposed study we will translate enormously promising home-based antimicrobial photodynamic therapy (aPDT), using an FDA-approved topical agent and light, to prevent infection in patients with OI implants by (1) optimizing and fabricating custom light tunnels that link directly to the OI abutment and (2) through an early phase clinical trial designed to demonstrate feasibility, acceptability, usability, preliminary efficacy and safety.

PI_NAMEs: GITAJN, IDA L (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: acceptability and feasibility;Adjuvant Therapy;Adoption;Amber;Aminolevulinic Acid;Amputation;Amputees;Animals;antimicrobial;Bacteria;Benchmarking;bone;Cells;chronic pain;Clinic;Clinical Trials Design;Custom;cytotoxic;design;Development;Devices;Distal;early phase clinical trial;early phase trial;effectiveness evaluation;efficacy evaluation;FDA approved;Femur;Free Radicals;Goals;Home;Human;Implant;In Vitro;in vivo;Incidence;Infection;Infection prevention;infection rate;infection risk;Light;limb loss;Limb Prosthesis;Limb structure;Link;Liquid substance;Measures;Mechanics;medical complication;Metals;Methods;microbial;Microbial Biofilms;microorganism;Modality;Monitor;Multi-Institutional Clinical Trial;Nature;Optical Coherence Tomography;Orthopedics;osseointegrated implant;Osseointegration;Outcome;Patients;Penetration;Photosensitizing Agents;Physical Function;Physiology;Povidone-Iodine;Procedures;Prosthesis;Protocols documentation;prototype;PUVA Photochemotherapy;Reactive Oxygen Species;reconstruction;Regimen;Rehabilitation therapy;Reproducibility;Research;residual limb;Residual state;Rodent Model;Safety;Saline;Self Administration;Series;side effect;Singlet Oxygen;Skin;Tobramycin;Topical agent;topical anti-microbial;Topical Antibiotic;Translating;treatment strategy;usability;Vancomycin;virtual biopsy;Work;wound care

PROJECT_TITLE: Advancing Antimicrobial Photodynamic Therapy to Prevent Infection in Osseointegrated Prosthesis Patients

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: RELEVANCE TO PUBLIC HEALTH In this high-risk, high-reward project, we have assembled a uniquely qualified team to explore novel applications of FUS to improve Chimeric antigen receptor T cell (CAR-T) therapy for glioblastoma (GBM) treatment. CAR-Ts are a promising new treatment platform that allows directed targeting and killing of tumor cells. We hypothesize that FUS-mediated BBB disruption will result in increased trafficking of systemically administered B7-H3.CAR- Ts to GBM tumors; and FUS therapy will improve overall anti-tumor efficacy of B7-H3.CAR-Ts by modulating the immunosuppressive tumor microenvironment.

PI_NAMEs: DAYTON, PAUL A (contact);RAUF, YASMEEN

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Ablation;Acoustics;Address;Adjuvant Chemotherapy;Animals;antitumor effect;Biodistribution;Biological;Biomedical Engineering;Blood - brain barrier anatomy;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;Brain Glioblastoma;Brain Neoplasms;brain tissue;CAR T cell therapy;CD276 gene;Cell Therapy;Cells;chemokine;chemotherapeutic agent;chemotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Research;clinical translation;Clinical Trials;Deposition;Diagnosis;Disease;efficacy evaluation;Essential Tremor;Excision;exhaustion;experience;experimental study;FDA approved;Focused Ultrasound;Focused Ultrasound Therapy;Glioblastoma;high reward;high risk;Human;image guided;immunoregulation;Immunotherapy;improved;improved outcome;In Vitro;in vivo;indexing;Inflammatory;Injections;intercellular cell adhesion molecule;Intravenous;Intraventricular;leukemia;Malignant Neoplasms;Mechanics;Mediating;Microbubbles;Microglia;Modeling;mouse model;Mus;nanoparticle;neoplastic cell;Normal tissue morphology;novel;novel strategies;Operative Surgical Procedures;overexpression;patient population;Patients;Phase I Clinical Trials;Physiologic pulse;Physiological;Pilot Projects;Positioning Attribute;Pre-Clinical Model;Primary Brain Neoplasms;Proliferating;Proteins;PTPRC gene;Public Health;Qualifying;Radiation therapy;response;Rodent;Rodent Model;Role;Route;Safety;small molecule;Specimen;success;Survival Rate;synergism;System;T-Lymphocyte;Tail;Technology;technology development;Therapeutic;Time;Time Study;Tissues;trafficking;tumor;Tumor Cell Line;tumor growth;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;Ultrasonic Therapy;Ultrasonography;ultrasound;Veins;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Novel approaches to enrich CAR-T cell Therapy in brain tumors using focused ultrasound

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (O2)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Diabetes;Neurodegenerative;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE  Type 2 diabetes mellitus is a serious health issue, which commonly has cognitive and mood dysfunctions, potentially from brain tissue changes resulting from impaired blood brain barrier function, which are associated with increased morbidity and mortality, early risks for dementia and Alzheimer’s disease, and reduced quality of life. We will examine whether a low-cost thiamine intervention can improve blood brain barrier function and reduce mood and cognition deficits in Type 2 diabetes mellitus adults. The findings will have direct public health implications and could reduce cognitive and mood deficits, and thus, advance the National Institutes of Health mission by dramatically impacting the morbidity, mortality, early risks for dementia, and quality of life in Type 2 diabetes mellitus patient population.

PI_NAMEs: KUMAR, RAJESH  (contact)

PROJECT_TERMS: Adult;Affect;affective disturbance;Aftercare;Alzheimer's Disease;Antibodies;Anxiety;arterial spin labeling;associated symptom;Bacteria;Beck depression inventory;Biological Markers;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood capillaries;blood-brain barrier function;Brain;brain tissue;Calcium-Binding Proteins;carbohydrate metabolism;Cell Physiology;Cell Respiration;Cerebrospinal Fluid;Chemicals;Clinical Trials;cofactor;Cognition;Cognitive;Cognitive deficits;cognitive testing;Contrast Media;cost;Data;Dementia;dementia risk;Diabetes Mellitus;Diagnosis;Diffusion;diffusion weighted;dimer;Dose;Double-Blind Method;Endothelial Cells;Endothelium;Equipment and supply inventories;Functional disorder;Health;Human;hydrophilicity;Impaired cognition;Impairment;improved;Infection;innovation;Intervention;Learning;Link;Magnetic Resonance Imaging;Measures;Memory;Methods;Microscopic;Mission;Moods;Morbidity - disease rate;mortality;Nerve Degeneration;nerve injury;neural;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;patient population;Patients;Pharmaceutical Preparations;Positron-Emission Tomography;pre-clinical;preclinical study;Procedures;Public Health;Quality of life;Radiation;randomized, clinical trials;repair function;repaired;Risk;Role;Self Care;Serum;single photon emission computed tomography;Site;Sodium Chloride;Thiamine;Thiamine Deficiency;Tissues;treatment comparison;treatment strategy;United States;United States National Institutes of Health

PROJECT_TITLE: Type 2 Diabetes Mellitus and Blood Brain Barrier Function Improvement- A Randomized Clinical Trial


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Ventilator-associated pneumonia (VAP) is one of the most common nosocomial infections with significant morbidity and mortality, and biofilms on endotracheal tubes are recognized to be a leading cause of VAP, and currently there are no available options that are both treatment-effective and cost-effective to prevent VAP effectively. In this application, we aim to explore the utility of a novel optical endotracheal tube (Optical-ETT), which emits antimicrobial blue light from the ETT surface, to prevent biofilm formation and eradicate preexisting biofilm on the ETT. A successful completion of the studies this application will provide the preclinical evidence required to determine the effectiveness and safety of the Optical-ETT, and will demonstrate the functionality of a prototype system of Optical-ETT.

PI_NAMEs: BERRA, LORENZO ;DAI, TIANHONG  (contact)

PROJECT_TERMS: Acinetobacter baumannii;Address;Affect;Animals;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;Attention;attributable mortality;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;Bronchoalveolar Lavage Fluid;Clinical;Colony-forming units;combat;cost;cost effective;cytokine;cytotoxic;dysbiosis;Effectiveness;effectiveness evaluation;Electrons;endotracheal;Euthanasia;Exhibits;Exposure to;Growth;Histology;Hospitals;Imaging technology;In Vitro;in vivo;Inflammatory;Inflammatory Response;innovation;Intensive Care Units;Intratracheal Intubation;Intubation;invention;Laboratories;Light;Lung;Measures;Mechanical ventilation;Microbial Biofilms;microscopic imaging;Modeling;Morbidity - disease rate;mortality;Motion;Nosocomial Infections;novel;operation;Operative Surgical Procedures;Optical Coherence Tomography;Optics;pathogen;Patients;Phototherapy;porcine model;Porphyrins;Postoperative Period;pre-clinical;prevent;Procedures;Protocols documentation;prototype;Pseudomonas aeruginosa;Reactive Oxygen Species;Regimen;Reporting;Resistance development;Resistance profile;Risk Reduction;Safety;Scanning;side effect;Silver;Staphylococcus aureus;Surface;Suspensions;System;Tissues;Trachea;Tube;ventilation;ventilator-associated pneumonia

PROJECT_TITLE: Antimicrobial blue light-activatable optical endotracheal tube to combat biofilms on the endotracheal tube

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Immunotherapy;Inflammatory Bowel Disease

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative Current inflammatory bowel disease (IBD) therapies offer insufficient long-term treatment management and have undesirable side effects, highlighting an unmet clinical need for new strategies that can sustain immune tolerance in IBD. The current proposal is aimed at understanding PD1 signaling in IBD patients, a major pathway implicated in peripheral immune tolerance, and leveraging the insights generated to maximize the efficacy of PD1 agonist monotherapy and low-dose IL-2 combination therapy in humanized IBD mouse models. The successful completion of this clinically oriented proposal has the potential to advance novel therapies for IBD and other autoimmune diseases.

PI_NAMEs: GOPAL, MURUGAIYAN  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Address;Affect;Agonist;Alpha Interleukin 2 Receptor;Animal Model;Autoimmune Diseases;Autoimmunity;Autologous;Biological Models;Calibration;CD4 Positive T Lymphocytes;cell type;Cells;Chimeric Proteins;Clinical;Clinical Trials;clinically significant;Colitis;Combined Modality Therapy;Crohn's disease;cytokine;Development;disease model;Dose;Functional disorder;Goals;gut inflammation;Helper-Inducer T-Lymphocyte;high dimensionality;Homeostasis;Human;humanized mouse;Immune;Immune response;Immune Tolerance;Immunoglobulins;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;insight;interest;Interleukin 2 Receptor;Interleukin-2;Intestines;Knock-in Mouse;Knockout Mice;Ligands;mouse model;Mus;Myelogenous;Myeloid Cells;novel;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peripheral;Persons;Prevalence;prevent;programmed cell death ligand 1;programmed cell death protein 1;Recombinants;Regulatory T-Lymphocyte;response;restraint;Role;side effect;Signal Transduction;single-cell RNA sequencing;T cell response;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Tissues;translational potential;Treg therapy;Ulcerative Colitis

PROJECT_TITLE: Development of novel PD1 agonist therapeutic strategies for inflammatory bowel disease

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Gene Therapy;Genetics;Orphan Drug;Rare Diseases

ORG_CITY: CHARLESTON

ORG_DEPT: DENTISTRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: The use of nucleic acids-based drugs has great potential for therapeutic applications in numerous diseases, including cancer. However, their delivery is challenging, as they face numerous biological barriers, and despite the development of many promising carrier technologies, achieving a clearer understanding of the mechanisms they employ to facilitate cell entry is in-part critical to advancing their clinical translation. Hence, the relevance of this project to public health is that it will shed new insights into our understanding of the cell entry mechanisms small protein carriers employ to target and deliver therapeutic nucleic acid-based drug cargos into cancer cells, with the potential to lead to an effective molecular targeted therapy for human cancer intervention.

PI_NAMEs: JAKYMIW, ANDREW GEORGE (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: 3-Dimensional;Actins;Antibodies;Architecture;Automobile Driving;Bacteria;Biochemical;Biological;cancer cell;Cancer Intervention;cancer therapy;Carrier Proteins;cell motility;Cell Nucleus;Cell Physiology;Cell Surface Extensions;Cell Surface Receptors;Cells;Chemicals;clinical translation;Complex;Cues;Cytoplasm;Dependence;design;Development;Disease;Environment;Exhibits;exosome;extracellular;Extracellular Matrix;Face;Filopodia;Fluorescence Microscopy;Future;Gene Silencing;Genes;Goals;high reward;high risk;Human;Image;In Vitro;in vivo;inhibitor;insight;Integrins;Invaded;knock-down;Knowledge;Label;Length;Lipids;macromolecule;Malignant - descriptor;malignant mouth neoplasm;Malignant Neoplasms;malignant oropharynx neoplasm;Mediating;Messenger RNA;Methods;MicroRNAs;microscopic imaging;migration;Molecular Biology;Molecular Target;molecular targeted therapies;mouse model;Neoplasm Metastasis;nucleic acid delivery;nucleic acid-based therapeutics;Nucleic Acids;Outcome;overexpression;Parents;Pattern;Penetration;Peptides;Pharmaceutical Preparations;plasmid DNA;Polymers;Public Health;receptor;Reporting;Research;Route;Sensory;siRNA delivery;Small Interfering RNA;spheroids;Structure;System;Technology;technology platform;Testing;Therapeutic;Thinness;three dimensional cell culture;trafficking;tumor;tumor progression;uptake;Variant;Virus;Western Blotting

PROJECT_TITLE: Delineating the mechanisms of filopodia-mediated intracellular delivery of siRNAs via peptide carriers towards the development of a molecular targeted therapy for oral cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (81)]


NIH_SPENDING_CATS: Clinical Research;Lung;Pulmonary Hypertension;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Idiopathic pulmonary arterial hypertension (IPAH) is a rare and fatal disease that predominantly affects women. Abnormalities in pulmonary arteries, the blood vessels in the lungs, have been shown to associate with the elevated blood pressure in the lungs. This study is designed to determine the role of membrane receptors and ion channels, proteins on cell surface membrane that mediate cell growth and mobility in the cellular processes that lead to the high blood pressure in the lungs in patients with this devastating disease, and to reveal potential novel targets for therapeutic approaches to treat IPAH.

PI_NAMEs: YUAN, JASON X J (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: 2019-nCoV;Affect;Animals;blood pressure elevation;Blood Vessels;Calcium;Cations;cell growth;Cell Mobility;Cell Physiology;Cell Proliferation;Cell surface;design;Development;Disease;E protein;Endothelial Cells;Endothelium;Etiology;FRAP1 gene;G-Protein-Coupled Receptors;Gene Expression Profile;Goals;GPR68 gene;Growth;Homeostasis;Human;Hypertension;Inflammasome;Ion Channel;Lesion;Lung;Mediating;Membrane;Mesenchymal;migration;Molecular;Muscle Contraction;new therapeutic target;novel therapeutics;Pathogenicity;Patients;Phenotype;Piezo 1 ion channel;primary pulmonary hypertension;programs;Progressive Disease;Proliferating;Proteins;Proto-Oncogene Proteins c-akt;pulmonary arterial hypertension;pulmonary artery endothelial cell;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular remodeling;Pulmonary Vascular Resistance;pulmonary vasoconstriction;receptor;Regulation;Research;Role;Signal Transduction;Smooth Muscle Myocytes;spatiotemporal;Stimulus;Succinates;Survival Rate;translational potential;Vascular remodeling;vasoconstriction;voltage;Woman

PROJECT_TITLE: Ion Channels and Membrane Receptors in Pulmonary Arterial Hypertension


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Rare Diseases;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: KINGSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: Project Narrative Cerebral amyloid angiopathy (CAA) is a prevalent vascular disease contributing to dementia in >50% of people over the age of 60 and in the majority of Alzheimer’s disease patients. CAA arises from amyloid deposits in the cerebral small blood vessels, and results in extensive neuroinflammation, vessel occlusion and vascular damage, microbleeds, and neurodegeneration. Inflammation is an important pathological component contributing to CAA progression, and this study will employ techniques in cell culture and animal models to investigate the impacts of the innate immune cell neutrophils on development of vascular damage and neuroinflammation in CAA.

PI_NAMEs: SCHRADER, JOSEPH M (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: abeta deposition;Address;Age;Aged, 80 and over;Aging;aging population;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;animal data;Animal Model;arm;Arteries;arteriole;Biological Markers;Blood Vessels;Brain;Brain region;brain tissue;Cardiovascular Diseases;Caring;Cell Culture Techniques;Cells;Cerebral Amyloid Angiopathy;cerebral capillary;Cerebral hemisphere hemorrhage;Cerebral Infarction;cerebrovascular;Cerebrovascular system;Cerebrum;Chronic;Chronology;Clinic;Clinical;clinically relevant;comorbidity;COVID-19;Dementia;Deposition;Development;Diabetes Mellitus;diagnostic biomarker;diagnostic tool;Disease;effective therapy;Event;extracellular;Generations;Hemorrhage;Human;Immune;Impaired cognition;In Vitro;Individual;Inflammation;Inflammatory;insight;Investigation;Iowa;Link;Malignant Neoplasms;Mediating;Modeling;Molecular;Molecular Profiling;Mutation;Nerve Degeneration;neuroinflammation;neutrophil;Neutrophil Activation;novel;Older Population;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Patient Care;Patients;Persons;Positioning Attribute;predictive modeling;Production;proteomic signature;Proteomics;Rattus;Reporting;response;Rheumatoid Arthritis;Role;Sepsis;Severities;Sporadic Cerebral Amyloid Angiopathy;Techniques;Therapeutic;Therapeutic Intervention;Thrombin;Thrombosis;thrombotic;Thrombus;Tissues;tool;transcriptomics;United States Dept. of Health and Human Services;vascular cognitive impairment and dementia;Vascular Diseases;Visualization

PROJECT_TITLE: Induction of Neutrophil Extracellular Traps by Beta-Amyloid Deposits in Cerebral Amyloid Angiopathy

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative  Infections by RNA viruses continue to pose global public health challenges, yet we still only poorly- understand both the host immune responses that inhibit RNA virus replication and the strategies used by these viruses to evade such host responses. Here we characterize a novel “FACT-ETS-1 Antiviral Response (FEAR)” Pathway we discovered that restricts RNA virus replication in human cells. We will identify human immunity genes regulated by the FEAR Pathway during RNA virus infection as well as identify RNA virus-encoded factors that antagonize this host response.

PI_NAMEs: GAMMON, DON BRAD (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Alleles;Amino Acid Substitution;Animals;antagonist;Anti-viral Response;antiviral immunity;Attenuated;Binding;blocking factor;Cell Nucleus;Cells;citrate carrier;combat;Complex;Cytoplasm;Data;DNA biosynthesis;DNA Viruses;Evolution;Expression Library;Family;Flavivirus;Gene Expression;Genes;Genetic Transcription;Goals;Grant;Health;Histones;Human;Immune Evasion;Immune response;Immune System Diseases;Immunity;Infection;inhibitor;Innate Immune Response;Integration Host Factors;Interferon Activation;Interferons;knock-down;Link;Mediating;member;Microbiology;Microtubules;Molecular Chaperones;multiple myeloma M Protein;Mus;mutant;Natural Immunity;Nature;next generation sequencing;novel;Nuclear Import;Nucleosomes;Para-Influenza Virus Type 1;parainfluenza virus;Paramyxovirus;pathogenic virus;Pathway interactions;Physiological;Poxviridae;prevent;protein function;Protein Subunits;Proteins;Public Health;Reporting;response;Rhabdoviridae;RNA Interference;RNA replication;RNA Virus Infections;RNA Viruses;Role;screening;Sendai virus;Sumoylation Pathway;Techniques;Testing;tool;transcription factor;Vaccinia virus;Vesicular stomatitis Indiana virus;Viral;Viral Genes;Viral Pathogenesis;virtual;Virulence;Virus;Virus Diseases;Virus Replication;Work;Yeasts;Yellow fever virus;Zika Virus

PROJECT_TITLE: Characterization of a Novel FACT-ETS-1 Antiviral Response Pathway and Identification of RNA Virus-Encoded Antagonists of this Host Response

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

PHR: PROJECT NARRATIVE Specific phobias and other fear-related disorders, such as post-traumatic stress disorder (PTSD), represent a major mental health problem as gold standard exposure therapy involves repeated exposure to feared stimuli, but the high levels of distress can lead to refusal to start or premature treatment termination. Recent advances in computational functional magnetic resonance imaging (fMRI) provide a method by which individuals may be unconsciously exposed to feared stimuli, leading to effective fear reduction while eliminating a primary cause of attrition. If successful, this approach may be extended to posttraumatic stress disorder (PTSD) and other fear-related disorders.

PI_NAMEs: CRASKE, MICHELLE G (contact);MOBBS, DEAN

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Affective;Aftercare;Amygdaloid structure;Animal Phobia;Animals;Anxiety Disorders;approach/avoidance behavior;Attention;behavior measurement;Behavioral;behavioral outcome;behavioral response;Birds;Brain;brain control;Bypass;Categories;Clinical;Conscious;Data;design;Development;Disease;Distress;dosage;Double-Blind Method;effective therapy;Emotional;Emotions;Exposure to;Face;follow-up;Fright;Functional Magnetic Resonance Imaging;Image;Individual;Intervention;Measures;Mediating;Mediation;Mental Health;Methods;Neurobiology;neuroimaging;novel;Panic;Panic Disorder;Participant;Patients;Pattern;Phobias;Pilot Projects;Placebo Control;Population;Positioning Attribute;Post-Traumatic Stress Disorders;premature;Procedures;psychologic;Psychological reinforcement;response;Rewards;Role;Sampling;Snakes;Social Anxiety Disorder;Specific Phobia;Spiders;standard care;Stimulus;Temporal Lobe;Testing;Time;Unconscious State;virtual reality;Visual;Work

PROJECT_TITLE: Unconscious reduction of fear through decoded neuro-reinforcement

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (06)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Lung;Lymphatic Research;Lymphedema;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pulmonary Hypertension;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Cardiovascular disease (CVD) is a leading cause of both adult and neonatal death in the US. Cardiac and vascular function depends on cardiac and smooth muscle electrical activity. We are using molecular, cellular, animal and human studies to understand the mechanistic basis of cardiovascular pathology resulting from altered electrical activity and to develop new specific therapies to treat such cardiovascular pathologies.

PI_NAMEs: NICHOLS, COLIN G (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Address;Adult;Animal Model;Animals;Biochemical;Biological;Blood Vessels;Cantu syndrome;Cardiac;Cardiac Output;Cardiovascular Diseases;Cardiovascular Pathology;Cardiovascular Physiology;Cardiovascular system;Cell model;Cells;Clinic;Development;Disease;gain of function;Genes;heart dimension/size;Human;human disease;Individual;interest;Ion Channel;Link;Lymphedema;Metabolism;Molecular;Motility;Mutation;Myocardium;Nature;Neonatal Mortality;novel;Pathologic;Pathology;Pericardial effusion;Peripheral Resistance;Persistent Fetal Circulation Syndrome;pharmacologic;Physiological;Potassium Channel;Proteins;Regulation;Research;Role;Smooth Muscle;Therapeutic;tool;Work

PROJECT_TITLE: Cardiovascular potassium channels: From molecular basis to disease therapeutics


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Many individuals with advanced heart failure experience poor outcomes including frequent admissions to the hospital. These outcomes are worse in racial and ethnic minority groups resulting in health inequities. Health inequities are often associated with social determinants of health (SDoH), which are the economic and social conditions that influence health. This project will investigate the SDoH of individuals with advanced heart failure and determine how their SDoH may influence future hospitalizations and if patients are receiving care in alignment with their values and goals. These findings will inform current care practices and provide a foundation for future studies to support patients with advanced heart failure more holistically.

PI_NAMEs: ANDERSON, KELLEY  (contact);GRONINGER, J. HUNTER

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: 18 year old;Achievement;Acute;Admission activity;Adult;Advance Care Planning;advanced disease;Affect;African American;age stratification;American Heart Association;beneficiary;black patient;Black race;burden of illness;Cardiac;Cardiomyopathies;care outcomes;Caring;Centers for Disease Control and Prevention (U.S.);Characteristics;Chronic;Cities;Clinical;clinical care;Clinical Research;cohort;Communities;community-level factor;Complex;Congestive Heart Failure;contextual factors;County;Diagnosis;disorder risk;Disparity;Economic Conditions;end of life;Enrollment;Equity;ethnic minority population;Exclusion Criteria;experience;Foundations;Future;Gender;Goals;Guidelines;Health;health care disparity;health disparity;health equity;Health equity research;health inequalities;health related quality of life;Healthcare;Heart failure;high risk;Home;Home environment;hospice environment;hospital readmission;Hospitalization;hospitalization rates;Hospitals;improved;inclusion criteria;indexing;Individual;instrument;Intervention;Interview;Kansas;Knowledge;Lead;lens;Location;Logistics;Measures;Medicaid;Medical Care Team;Meta-Analysis;Methodology;Methods;Operative Surgical Procedures;Outcome;patient oriented;Patient Preferences;Patients;Perception;phenomenological models;Population;Population Heterogeneity;posthospitalization care;primary outcome;Procedures;prospective;Protocols documentation;Questionnaires;Race;racial difference;racial diversity;racial minority population;racial population;Reporting;Research;residence;Risk;Sampling;Science;secondary outcome;Site;Social Conditions;social group;social health determinants;Social support;social vulnerability;sociodemographics;Socioeconomic Status;structural determinants;Structure;Syndrome;Terminal Disease;Testing;Time;Variant;Work

PROJECT_TITLE: Impact of social determinants of health on post-hospitalization outcomes and goal-concordant care in patients with advanced heart failure

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Completely noninvasive neuromodulation using transcranial ultrasound stimulation (TUS) offers the promise of precisely stimulating specific targets deep in the brain, such as the nucleus accumbens for substance abuse disorders, at low power levels commonly used for diagnostic imaging studies. It is currently under active investigation in humans. However, when it comes to safety, we are compelled to examine all existing data. In particular, we seek to extend a prior analysis of TUS to the sheep brain to the examination of inflammatory cytokines and the examination of glial cells using immunohistochemistry.

PI_NAMEs: BUTTS-PAULY, KIM  (contact)

PROGRAM_OFFICER_NAME: ALVAREZ, RUBEN PAUL

PROJECT_TERMS: Acoustics;Addictive Behavior;Affect;aged;Animal Model;Astrocytes;behavioral study;Biological Assay;Brain;brain cell;cell type;Cells;Cephalic;Clinical Trials;cytokine;Data;data sharing;Diagnostic Imaging;digital imaging;Disease;Dose;Epilepsy;experience;Histologic;histological studies;Histology;Human;Image;imaging study;Immune;Immunohistochemistry;In Situ Nick-End Labeling;Inflammatory;Inflammatory Response;Institutional Review Boards;Investigation;Lateral Geniculate Body;Location;Manuscripts;Mental Depression;Mental Health;Metabolic;Methods;Microglia;Molecular;Morphology;Neuroglia;Neurologic;Neurons;neuroregulation;noninvasive brain stimulation;Nucleus Accumbens;Outcome;Pain;Persons;Physiologic pulse;Population;pressure;Publishing;Qualifying;Radiation;Reaction;Reporting;Research;Research Personnel;Resolution;response;Safety;secondary analysis;Sheep;Sonication;Source;Spottings;Stains;Stress;Substance abuse problem;Substance Use Disorder;substance use treatment;Time;Tissues;Titrations;tool;Ultrasonography;ultrasound;Visual evoked cortical potential;Visualization;Work

PROJECT_TITLE: Secondary Histologic Analysis of TUS Studies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (91)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Services

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PEDIATRICS

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Current models of operations and research involving clinical decision support (CDS) are too site-specific, not scalable, and do not measure translational outcomes. We propose to create a collaborative infrastructure centered around reusable CDS metrics that more effectively measures clinical outcomes and compares these benefits against the tradeoffs of alert burden and fatigue. Through our collaborative approach across ten CTSA Hubs, this study will be the first to use a translational science approach to understand the impact of CDS systems.

PI_NAMEs: KIRKENDALL, ERIC STEVEN (contact);MUTHU, NAVEEN

PROGRAM_OFFICER_NAME: GOPAL-SRIVASTAVA, RASHMI

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;Assessment tool;Automobile Driving;Benchmarking;Caring;Catalogs;catalyst;Clinical;clinical care;clinical decision support;Clinical Decision Support Systems;Clinical effectiveness;clinical implementation;Clinical Informatics;clinical outcome measures;clinical practice;Clinical Research;clinical translation;Collaborations;collaborative approach;Communities;COVID-19 vaccine;Data;data interoperability;data sharing;Dedications;design;Development;Effectiveness;Electronic Health Record;Electronics;Elements;Eligibility Determination;Evaluation;evidence base;Evidence based practice;experience;Expert Opinion;falls;Fatigue;Foundations;Future;Goals;health care service organization;Heterogeneity;implementation evaluation;implementation framework;implementation/effectiveness;improved;Individual;Informatics;Infrastructure;innovation;Institution;instrument;Intervention;Learning;Life Cycle Stages;Link;Measures;Medical;member;Meta-Analysis;Minority;Modeling;Modernization;Multicenter Studies;next generation;operation;organizational readiness;Outcome;Participant;Performance;Phase;Preparation;Process;programs;Public Health;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Recommendation;Research;research clinical testing;Research Project Grants;research to practice;Resources;response;Safety;Shapes;Site;Structure;success;support tools;synergism;System;Talents;Testing;Time;Translation Process;Translational Research;vaccine acceptance;Work

PROJECT_TITLE: Bytes to Bedside: Collaborative Development for Translational Clinical Decision Support

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-4 (01)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Hearing Loss;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Usher Syndrome

ORG_CITY: SYRACUSE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Project Narrative This research is relevant to public health because Usher syndrome type II are genetic diseases that causes blindness through degeneration of the retina. The goals are to generate appropriate models for testing experimental therapeutics for retinal degeneration.

PI_NAMEs: HU, HUAIYU  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Adhesions;Adult;Animal Model;Animals;Applications Grants;assisted reproduction;autosome;Birth;Blindness;Callithrix;Callithrix jacchus jacchus;cell replacement therapy;Cilia;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;Cone;congenital hearing loss;Development;Disease;effective therapy;Embryo;Exhibits;Female;Frameshift Mutation;Future;G-Protein-Coupled Receptors;Generations;Genes;Genetic Diseases;Genetic study;Genome;genome editing;Goals;Health;Hearing;hearing impairment;Human;Implant;Investigational Therapies;Laboratories;Missense Mutation;Modeling;Molecular;Molecular Genetics;molecular targeted therapies;Mus;mutant;Mutate;Mutation;Night Blindness;Nonsense Mutation;Oocytes;Pathologic;Patients;Phenotype;photoreceptor degeneration;Photoreceptors;preservation;prevent;Primates;Proteins;Public Health;recessive genetic trait;Research;Retina;Retinal Degeneration;Retinitis Pigmentosa;sight restoration;targeted treatment;Teenagers;Testing;therapy development;Translational Research;USH2A gene;Usher Syndrome;Usher Syndrome Type 1;Usher Syndrome Type 2;V1 Receptors;Vision;WHRN gene;Work;Zebrafish

PROJECT_TITLE: Generation of a new model for Usher syndrome.

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Childhood Injury;Clinical Research;Data Science;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Rural Health;Suicide;Suicide Prevention;Telehealth

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Text-message-based services have the potential to greatly improve access to crisis evaluations for persons who are at risk of suicide, especially for adolescents and young adults who may be more comfortable using text-based platforms than voice-based telephone services. Utah has made a statewide text-message-based crisis service (SafeUT) available to teens and young adults since 2017. We propose to use cutting-edge machine learning techniques to identify features of rigorously anonymized SafeUT text conversations that predict key outcomes, like involvement of emergency services and loss to follow-up, and quality measures like the completion of a suicide risk assessment, in order to develop a system for evaluating and improving SafeUT services.

PI_NAMEs: KIOUS, BRENT MICHAEL (contact);SRIKUMAR, VIVEK

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Address;Adolescent and Young Adult;age group;Artificial Intelligence;Assessment tool;care delivery;care outcomes;Caring;Cellular Phone;Child;Clinical;Code;Crisis Intervention;Data;Decision Making;Decision Support Systems;Development;Distress;Dropout;Emergency medical service;Ensure;Evaluation;evidence base;Expert Systems;Face;Failure;Feedback;Feeling suicidal;follow-up;Future;Goals;Government Agencies;Hospitals;Human;Improve Access;improved;innovation;interest;Intervention;Licensing;Life;Link;Machine Learning;Measures;Mental Health;Mental Health Services;Modeling;Monitor;Natural Language Processing;next generation;Outcome;Outcome Assessment;Persons;point of care;Policies;prediction algorithm;predictive modeling;premature;Professional counselor;programs;provider factors;reducing suicide;repository;Request for Applications;Research Priority;Resolution;response;Risk;Risk Assessment;rural area;Safety;service delivery;Services;Social Workers;State Government;suicidal morbidity;suicidal risk;System;Techniques;Teenagers;telephone based;Text;Text Messaging;Time;Training;Triage;Universities;Utah;Voice;young adult;Youth

PROJECT_TITLE: Predicting point-of-care outcomes for text message crisis interventions in teens

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Mesothelin is one of the few tumor-specific antigens. Our long-term goal is to develop MSLN-targeting domain antibodies that will be utilized to design therapeutic reagents. MSLN is highly relevant to environmentally caused disease and human health. In this research, we propose to develop a system that directly screens biparatopic human heavy chain domain antibody.

PI_NAMEs: ISHIMA, RIEKO  (contact);LI, WEI

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: Affinity;Amino Acids;Animals;Antibodies;Antibody-drug conjugates;antigen binding;Antigen Receptors;Antigens;Bacteriophages;Binding;Binding Sites;CAR T cell therapy;Cell Surface Proteins;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;complementarity-determining region 3;Complex;Cryoelectron Microscopy;Data;design;Development;Disease;Distant;Ensure;Environment;Epitopes;Exhibits;flexibility;Future;Goals;Health;Human;Immunoglobulin Fragments;Immunology;Immunotoxins;improved;Individual;Length;Libraries;Ligand Binding Domain;Link;Lung Adenocarcinoma;Malignant Neoplasms;Maps;Mesothelial Cell;mesothelin;Mesothelioma;Methods;Mutagenesis;mutant;Mutation;nanobodies;neoplasm immunotherapy;novel;overexpression;Penetration;Phage Display;protein protein interaction;Reagent;Research;restriction enzyme;scale up;screening;Screening Result;Site;small molecule;Solid Neoplasm;Stretching;Structure;Surface Plasmon Resonance;System;targeted treatment;Testing;Therapeutic;Therapeutic antibodies;Tissues;tumor;Tumor Antigens

PROJECT_TITLE: Development of a biparatopic-domain antibody screening system

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: EB

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE: The generation of a robust disease-specific immune response remains a critical challenge in the design of cancer immunotherapies and infectious disease vaccines. Activation of innate immune signaling pathways via synthetic mimics of pathogen-associated molecular patterns is highly promising for augmenting vaccine efficacies, but key knowledge and technological gaps remain in designing such molecules. To address these challenges, we will engineer a molecularly defined, modular “all-in-one” RNA platform for targeted combinatorial innate immune activation.

PI_NAMEs: WU, CONNIE  (contact)

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: Address;Adjuvant;Agonist;anti-tumor immune response;Antigen-Presenting Cells;Benchmarking;Bone Marrow;cancer immunotherapy;Cell Line;Cell Wall;Cells;Clinical;combinatorial;Communicable Diseases;Complex;CPG-oligonucleotide;cytokine;Dendritic Cells;design;Disease;DNA;Double-Stranded RNA;Elements;Endowment;Engineering;Ensure;Face;Future;Generations;Genes;Immune;immune activation;Immune response;Immune signaling;Immune Targeting;Immunologic Adjuvants;in situ vaccine;In Vitro;in vivo;in vivo evaluation;innate immune pathways;Innate Immune Response;Innate Immune System;Knowledge;lipid nanoparticle;Malignant Neoplasms;Mannans;Melanoma;Modality;Molecular;mouse model;multimodality;Nature;pathogen;Pathway interactions;Patients;Pattern;Pattern recognition receptor;Polymers;Polysaccharides;rational design;Receptor Activation;Reporter;RNA;RNA Viruses;Route;scaffold;Signal Pathway;Structure;Structure-Activity Relationship;success;System;Technology;Testing;Therapeutic;therapeutic RNA;TLR3 gene;TLR7 gene;Toll-like receptors;tool;translational potential;Treatment Efficacy;Tretinoin;tripolyphosphate;Tumor Burden;uptake;Vaccine Adjuvant;vaccine efficacy;vaccine immunotherapy;Vaccines;Vertebral column;Work

PROJECT_TITLE: Programmable 'all-in-one' RNA as a molecular scaffold for targeted combinatorial innate immune activation


NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;Contraception/Reproduction;Health Services;Homicide and Legal Interventions;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Physical Injury - Accidents and Adverse Effects;Pregnancy;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Homicide is a leading cause of death during pregnancy and postpartum in the US. This project seeks to optimize health care settings as critical windows of opportunity to identify and respond to pregnant and postpartum women experiencing intimate partner violence that may lead to homicide. Finding from this study – informed by both health care providers and survivors of violence during pregnancy and postpartum – will help to establish effective and efficient practices, policies, and procedures that can protect the health and safety of women during pregnancy and beyond.

PI_NAMEs: DOWNEY, MARGARET MARY BISSEMBER;WALLACE, MAEVE E (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Accident and Emergency department;Age;American College of Obstetricians and Gynecologists;care providers;Caring;Cause of Death;Cities;Clinical;Conceptions;Data Collection;Development;Disclosure;evidence base;experience;Failure;Family Planning;Focus Groups;Future;Geography;Goals;Health;health care settings;Health Personnel;Health protection;Health Services;Hemorrhage;Homicide;Hypertension;improved;Infection;Intervention;Intervention Studies;intimate partner violence;Lactation consultant;Leadership;Lived experience;Louisiana;Maternal Mortality;Methods;Midwife;mortality;Observational Study;obstetric care;patient oriented;Patients;pediatrician;Perinatal;Persons;Policies;Population;Postpartum Period;Postpartum Women;preference;Pregnancy;pregnant;Pregnant Women;prenatal;prevent;preventable death;Procedures;Process;Productivity;programs;Provider;public health intervention;Recommendation;recruit;Registered nurse;Reporting;Reproduction;reproductive;Research;response;Risk;Role;Safety;screening;service delivery;Social Work;Stigmatization;Structure;Survivors;System;Techniques;Time;Violence;violence prevention;Visit;Voice;Weight;Woman;Women's mortality;Work

PROJECT_TITLE: Provider and Survivor Perspectives on Screening for Intimate Partner Violence During Pregnancy and Postpartum

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]