NIH_SPENDING_CATS: Cancer;Genetics

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: Project Narrative Loss of the methylthioadenosine phosphorylase gene (MTAP) is one of the most frequent genetic alterations found in human cancer. In this proposal, we will explore the mechanism by which MTAP loss affects tumorigenesis. These studies could lead to novel strategies to target MTAP loss and potentially lead to novel treatments to treat cancer.

PI_NAMEs: KRUGER, WARREN D (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Adenosine;Affect;Antibodies;Arginine;cancer cell;Cell Line;Cell Physiology;Cells;Cyclic AMP;Data;dimethylarginine;Enzymes;Epitopes;extracellular;Family;Gene Expression Profile;Genes;Genetic;Genetic Screening;Goals;Hematologic Neoplasms;Housekeeping;Human;inhibitor;Invaded;knock-down;Liquid substance;Location;Malignant Neoplasms;Mediating;Messenger RNA;Metabolic;Methionine;Methylation;migration;Modification;Multienzyme Complexes;Mutation;neoplastic cell;novel;novel strategies;novel therapeutic intervention;Pathway interactions;pharmacologic;Phosphorylases;Play;Process;Protein Inhibition;Protein-Arginine N-Methyltransferase;Proteins;Purinergic P1 Receptors;response;Role;Signal Transduction;small hairpin RNA;Solid;System;tandem mass spectrometry;Testing;transcriptome sequencing;tumor;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenesis;Western Blotting;Work

PROJECT_TITLE: MTAP, 5'-deoxy-5'-methylthioadenosine, and the dysregulation of symmetric dimethylarginine in cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Blood cells are derived from bone marrow progenitor cells and released into circulation, where they play key roles in oxygen transport, immune response, and blood clotting. In the proposed research, we assemble the largest collection of participants with blood cell traits and whole genome sequencing and apply rigorous scientific methods to interrogate genome-wide structural variation and functional characterization of the blood cell associated structural variants. Results generated from this research may contribute to a better understanding of blood cell biology and pave the way for new research into precision medicine for blood diseases.

PI_NAMEs: BAUER, DANIEL EVAN;PANKRATZ, NATHAN D;REINER, ALEXANDER P (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: 3-Dimensional;Algorithms;alpha Globin;Area;Atlases;biobank;Biological;Biological Models;Biology;Blood;Blood Cells;Blood coagulation;Blood Platelets;Bone Marrow Cells;candidate validation;Cardiovascular Diseases;Cardiovascular system;Cells;Cellular biology;Chromatin;Circulation;Clinical;clinical diagnosis;Clinical Trials Design;clinically relevant;cohort;Collaborations;Collection;Complex;Computer software;Data;Data Set;database of Genotypes and Phenotypes;Disease;Disease Outcome;DNA Sequence;Ensure;epidemiology study;epigenome editing;Erythrocytes;Experimental Designs;functional genomics;gene editing technology;gene-editing approach;Genes;Genetic;genetic architecture;genetic association;Genetic study;Genome;genome editing;genome sequencing;genome wide association study;genome-wide;genome-wide analysis;Genomic Segment;genomic variation;Genomics;Genotype;Heart Diseases;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic;Hemostatic function;Heritability;Human;Human Biology;Immune response;improved;Individual Differences;Inflammation;insight;interdisciplinary approach;Leadership;Leukocytes;Lung;Lung Diseases;Measures;Methodology;Methods;Modeling;Molecular;multi-ethnic;Multiomic Data;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;novel;Outcome;oxygen transport;Participant;Pathogenesis;Phase;Phenotype;Play;Population;precision medicine;programs;Regulation;Repetitive Sequence;Research;Research Personnel;Resources;Role;Sample Size;Sampling;Sleep;Source;stem cells;Structure;Testing;Thrombosis;Time;trait;Trans-Omics for Precision Medicine;transcriptome sequencing;translational genetics;treatment response;Variant;venous thromboembolism;whole genome;working group

PROJECT_TITLE: Structural Variation and Hematological Traits

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Major gaps remain in our understanding of how the immune system recognizes and limits the growth of pathogens at the epithelial border and this proposal will provide new insights into how the CD40-CD40L interaction directs mucosal immunity to infection. The proposed studies leverage a newly tractable pathogen model that shows remarkable specificity to ECs and provides robust in vivo readouts of infection, control, and protection. The mechanisms discovered in the course of this program will be broadly relevant to the study of diseases of the intestinal tract of infectious, inflammatory and malignant etiology where CD40L has been implicated.

PI_NAMEs: HUNTER, CHRISTOPHER A (contact);STRIEPEN, BORIS

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Address;Affect;Agonist;Antigens;antimicrobial;B-Lymphocytes;candidate identification;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;Cell surface;Cells;Cellular Immunology;Child;Chronic;Communication;Communities;Cryptosporidium;Defect;Dendritic Cells;Development;diarrheal disease;Disease;Elements;Engineering;enteric infection;enteric pathogen;Enterobacteria phage P1 Cre recombinase;Enterocytes;Epithelial Cells;Epithelium;Etiology;Event;Experimental Models;experimental study;Gene Expression Profiling;Gene Transfer Techniques;genetic approach;Growth;Human;IFNGR1 gene;Immune;Immune response;Immune system;Immunity;Immunocompromised Host;Immunoglobulin Class Switching;in vivo;Infection;Infection Control;Inflammatory;Inflammatory Response;insight;Interferon Type II;Intestinal Diseases;Licensing;Life;Ligation;lymphoid structures;Malignant - descriptor;Mediating;Modeling;mouse model;Mucosal Immunity;Mucous Membrane;Mus;Mutation;novel;Outcome;Parasite Control;Parasites;Parasitic infection;pathogen;Pathway interactions;Patients;Population;Production;programs;protective effect;Regulation;Resistance;resistance mechanism;Resistance to infection;response;Role;Signal Transduction;single cell sequencing;Site;Specificity;Sterility;Surveys;T cell response;T-Cell Activation;T-Lymphocyte;Technology;Testing;TNFRSF5 gene;TNFSF5 gene;Work;x-linked Hyper-IgM Syndrome

PROJECT_TITLE: The role of CD40L in resistance to enteric infection


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cardiovascular;Genetics;Obesity;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Environmental toxicants, such as arsenic in drinking water, pose a significant risk for causing skeletal muscle myopathies and reduced regenerative capacity, as well as reduced contribution of muscle metabolism to systemic homeostasis; processes that are among the greatest factors contributing to declines in functional mobility and strong predictors of mortality. If successful, these studies will identify clinically relevant and immediately tractable strategies to reverse pathogenic muscle metabolism and maintenance from chronic arsenic exposures. The implication would be reduced arsenic-induced metabolic and cardiovascular disease burden, as well as reduced global burden of muscle quality decline that is an ever-increasing concern in aging populations.

PI_NAMEs: BARCHOWSKY, AARON  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Acute;Affect;Aging;Arsenic;autocrine;Autocrine Communication;Bioenergetics;bisulfite sequencing;burden of illness;Cancer Burden;cancer survival;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cell Communication;Cell Differentiation process;Cells;Choristoma;Chronic;clinically relevant;Communication;Disease;Disease Outcome;disorder risk;drinking water;Environmental Exposure;epidemiology study;Epigenetic Process;epigenetic regulation;Exposure to;extracellular vesicles;Functional disorder;Generations;Goals;Homeostasis;Human;Impairment;in utero;in vivo;Individual;Injury;Insulin Resistance;insulin sensitivity;intercellular communication;Intervention;Investigation;Knowledge;lean body mass;Liver;Liver diseases;Maintenance;Malignant neoplasm of liver;Mediating;Memory;Metabolic;Metabolic Diseases;Metabolism;MicroRNAs;Mitochondria;Mobility decline;Morbidity - disease rate;mortality;Mus;Muscle;muscle form;Muscle function;muscle metabolism;Muscle Mitochondria;muscle progenitor cell;muscle regeneration;Muscular Atrophy;Myopathy;Natural regeneration;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear;Obesity;Organ;paracrine;Paracrine Communication;Pathogenesis;Pathogenicity;Pathway interactions;Peptides;Phenotype;Population;prevent;Process;progenitor;programs;Protective Agents;Reactive Oxygen Species;receptor;Regenerative capacity;Relative Risks;repaired;response;Risk;Severities;Signal Transduction;Skeletal Muscle;skeletal muscle metabolism;stem cell fate;stem cell function;stem cell niche;stem cell population;stem cells;Structure;Systemic disease;Testing;Thinness;tissue regeneration;Tissues;Toxic Environmental Substances;transcriptome sequencing;Translating;vesicular release;whole genome;Work;young adult

PROJECT_TITLE: Dysfunctional skeletal muscle communication in arsenic-promoted cardiometabolic disease

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ADMINISTERING_IC: LM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Multiple Sclerosis;Neurodegenerative;Neurosciences;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE MS Falls InsightTrack is a live, accessible, mobile personal health library for people with multiple sclerosis (MS) that in the short term, will increase the tracking of falls and their reporting to clinicians, provide insight into reasons for falls and strategies to prevent them (including community-level determinants), and support patient and clinician behaviors designed to reduce the incidence and severity of falls. A significant innovation is the closed loop that delivers patient-generated data (from wearables and patient self- reports) into the clinician's workflow, then returns these data, processed and integrated with relevant clinical and community-level data in actionable visualizations, back to patients. In the longer term, the human-centered design and modular nature of the technological build, which uses SMART-on-FHIR standards and integrates with the Epic EHR, will ensure the tool is accessible to diverse patients, can be generalized to other conditions characterized by fall risk, and can be widely scaled for any number of conditions or wearable technologies.

PI_NAMEs: BOVE, RILEY MARIE BROWNE (contact)

PROGRAM_OFFICER_NAME: WANG, YANLI

PROJECT_TERMS: Adoption;Adult;Atlases;Back;Behavior;Behavioral;Behavioral Model;care systems;Chronic;Clinic;Clinical;clinical decision-making;Clinical effectiveness;clinical encounter;Clinical Investigator;clinical practice;Clinical Research;clinical risk;Clinical Trials;clinically relevant;cohort;Communication;Communities;Data;design;Development;Devices;Diamond;digital;digital divide;digital health;digital technology;Effectiveness;effectiveness evaluation;effectiveness measure;efficacy trial;Electronic Health Record;Ensure;experience;Fall prevention;fall risk;falls;Fast Healthcare Interoperability Resources;Feedback;fitbit;flasks;Focus Groups;Geriatrics;Grant;Health;Health Care Costs;health determinants;health literacy;Health system;high risk;Home;human centered design;implementation science;Incidence;Individual;Industry;Industry Standard;Infrastructure;innovation;insight;Institution;Intervention;Interview;Libraries;Life;Measures;Modernization;Monitor;Morbidity - disease rate;multidisciplinary;multimodal data;Multiple Sclerosis;multiple sclerosis patient;Nature;Neighborhoods;Orthopedics;Outcome;Parkinson Disease;Participant;Patient Compliance;Patient Outcomes Assessments;Patient Recruitments;Patient Self-Report;Patients;Phase;point of care;prevent;primary outcome;Process;prospective;prototype;provider behavior;Pythons;Qualifying;Recommendation;Reporting;Resources;Risk;Self Management;Series;Severities;shared decision making;social health determinants;Societies;sociodemographics;Socioeconomic Status;Technology;Testing;Time;tool;uptake;usability;Validation;Visualization;walkability;wearable data;wearable device;wearable sensor technology;Weather;Work

PROJECT_TITLE: MS Falls InsightTrack (MS FIT): A personal health library to reduce falls in patients with MS

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Sleep Research

ORG_CITY: HOUSTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Myocardial ischemia-reperfusion injury (IRI) has a profound impact on morbidity and mortality of surgical patients. Evidence suggests that the occurrence of myocardial ischemia-reperfusion injury follows a circadian pattern, with more severity of injury in the early morning. The current project aims to better understand the crosstalk between hypoxia (HIF2A) signaling and circadian rhythm (BMAL1) pathways to define novel strategies for the treatment or prevention of myocardial IRI.

PI_NAMEs: ELTZSCHIG, HOLGER K. (contact);MUEHLSCHLEGEL, JOCHEN DANIEL;TSAI, KUANG-LEI

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: 3-Dimensional;Address;Amino Acids;Amphiregulin;Anticoagulation;aortic valve replacement;Applications Grants;Area;AREG gene;ARNTL gene;bHLH-PAS factor HLF;Binding;Biochemical;biophysical analysis;Biopsy;Cardiac Surgery procedures;cardioprotection;circadian;Circadian Rhythms;Clinical;Co-Immunoprecipitations;Complex;Critical Care;Cryoelectron Microscopy;Data;differential expression;DNA;electron density;Exposure to;Genes;Genetic study;Genetic Transcription;Goals;Hemorrhage;Heterodimerization;Hour;Hypoxia;In Situ;In Vitro;in vivo;Infarction;Injury;Intervention;Left;Left ventricular structure;Link;Maps;Mass Spectrum Analysis;Mediating;Medicine;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Muscle Cells;myocardial injury;Myocardial Ischemia;Myocardial Reperfusion;Myocardial Reperfusion Injury;Myocardium;Myosin ATPase;novel;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;organ injury;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;percutaneous coronary intervention;Periodicity;Perioperative;pharmacologic;Pharmacology Study;Platelet Inhibitors;prevent;Prevention;promoter;Prospective Studies;protective pathway;Proteins;randomized, clinical trials;Regulation;Research Proposals;Resistance;Resolution;Response Elements;Retrospective Studies;Risk;Role;Severities;Signal Transduction;Site;Structure;targeted treatment;Therapeutic Intervention;therapeutic target;Time;transcription factor;transcriptome sequencing;Transgenic Mice;treatment strategy;Variant;Ventricular

PROJECT_TITLE: Circadian Rhythm as a Therapeutic Target for Perioperative Cardioprotection

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE – CENTER OVERVIEW The Diabetes Research Center at the University of Washington has a long-standing tradition and record of facilitating scientific investigation aimed at informing on how best to treat and prevent diabetes, obesity, and related disorders. Through its biomedical research cores, Pilot and Feasibility Program as well as its Enrichment Program, it will continue to support over 120 scientists in the Greater Seattle area and beyond who are pursuing basic, translation and clinical investigation in these areas.

PI_NAMEs: KAHN, STEVEN EMANUEL (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Area;base;Basic Science;Bioinformatics;Biomedical Research;Body Weight;Cell Culture Techniques;Cells;cellular imaging;clinical care;clinical investigation;Clinical Research;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;collaborative environment;Communities;Complications of Diabetes Mellitus;Confocal Microscopy;CRISPR/Cas technology;Development;Diabetes Mellitus;Direct Costs;Discipline;Disease;disorder prevention;doctoral student;Education;Educational workshop;Ensure;Environment;epidemiology study;equity, diversity, and inclusion;Etiology;Faculty;Fellowship;Financial Support;Fostering;Functional disorder;Funding;Generations;glucose metabolism;Goals;graduate student;Grant;Histopathology;Immunohistochemistry;improved;in vivo;innovation;Institution;Insulin-Dependent Diabetes Mellitus;Investigation;islet;lectures;Mass Spectrum Analysis;Metabolic;Mission;Modernization;molecular imaging;Mus;Names;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;Pathogenesis;Patient-Focused Outcomes;Peer Review;Phenotype;Postdoctoral Fellow;prevent;Prevention;programs;Proteomics;Regulation;Research;Research Methodology;Research Personnel;Research Support;Resources;response;Scientist;Services;Sum;symposium;Technology;tool;Training;Training and Education;Transgenic Animals;Transgenic Mice;Translating;Translational Research;Underrepresented Minority;United States National Institutes of Health;Universities;vector;Viral Vector;Wages;Washington;Work

PROJECT_TITLE: Diabetes Research Center


NIH_SPENDING_CATS: Diabetes;Nutrition

PROJECT_TERMS: Area;Awareness;Biomedical Research;Collaborations;Communication;Communities;cystic fibrosis related diabetes;Dedications;Diabetes Mellitus;Disease;Education;Educational workshop;Endocrinology;Ensure;Environment;equity, diversity, and inclusion;Evaluation;Event;Faculty;Funding;Future;Goals;graduate student;Grant;Human Resources;Immunology;improved;Information Centers;information gathering;innovation;Institution;Insulin-Dependent Diabetes Mellitus;interest;Joints;Leadership;lectures;Medical Students;meetings;Mission;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;novel;nutrition;Obesity;operation;outreach;Periodicals;Postdoctoral Fellow;posters;Process;programs;Progress Reports;Provider;Publications;Records;Research;Research Institute;Research Personnel;Resources;Rotation;Scientist;Services;success;symposium;Training;Training and Education;Universities;Visit;Washington;web site;Work

PROJECT_TITLE: Admin Core (with Enrichment Program)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: LUBBOCK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

PHR: Project Narrative The goal of the current project is to evaluate SLC6A14 as a viable drug target for PDAC, characterize autophagy and macropinocytosis induced in response to SLC6A14 inactivation, and to test the efficacy of a combination therapy that concurrently targets SLC6A14 and autophagy/macropinocytosis for a better therapeutic outcome in PDAC. This will be achieved by genetic deletion or pharmacological blockade of Slc6a14 in KPC mice, characterizing autophagy and macropinocytosis in SLC6A14-inactivated human PDAC cell lines and KPC tissue samples, and by testing combination therapy in human PDAC cell lines and orthotopic implantation mouse models of PDAC.

PI_NAMEs: BHUTIA, YANGZOM DOMA  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Amino Acid Transporter;Amino Acids;anti-cancer;Area;Aspartate;Attenuated;attenuation;Autophagocytosis;Biochemical;Biological;cancer cell;Carbon;Cell Line;Cells;Combined Modality Therapy;Compensation;deprivation;Development;DNA;Drug Combinations;Drug Targeting;efficacy testing;Essential Amino Acids;experimental study;Genetic;Genetic Models;Glutamates;Glutathione;Goals;Growth;histone methylation;Human;Hydroxychloroquine;implantation;improved;In Vitro;in vivo Model;inhibition of autophagy;innovation;interest;knock-down;KPC model;KRASG12D;Laboratories;Lesion;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;metabolomics;Modeling;Molecular;molecular marker;Monitor;mouse model;neoplastic;Non-Essential Amino Acid;novel;Nutrient;nutrition;Oxidative Stress;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pancreatic Intraepithelial Neoplasia;pancreatic neoplasm;pharmacologic;Process;Proteomics;Publishing;response;Sampling;Signal Pathway;Signal Transduction;Starvation;Stress;targeted treatment;Testing;therapy outcome;Tissue Sample;Treatment Efficacy;treatment strategy;Tryptophan;Tumor Tissue;Up-Regulation;Xenograft procedure

PROJECT_TITLE: SLC6A14 as a unique drug target to treat pancreatic cancer

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pediatric;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Research has shown that adherence to evidence-based asthma guidelines leads to improved outcomes, yet critical gaps remain in the implementation of these guidelines, particularly among minority and low-income youth. Schools represent a crucial point of intervention, as demonstrated by school-based asthma programs that have addressed individual components of the guidelines with promising results. This proposal aims to develop, implement, and evaluate a pragmatic, multi-component asthma program that builds upon existing targeted interventions to fully implement the asthma guidelines and integrate them in school practices to foster sustainability.

PI_NAMEs: VOLERMAN, ANNA  (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Absenteeism;Address;Adherence;Administrator;Advisory Committees;Affect;Area;Asthma;Award;Awareness;Black race;care providers;Caring;Chicago;Child;Childhood;Childhood Asthma;Chronic;Chronic Disease;Communication;Communities;community based participatory research;community engaged research;community intervention;Consolidated Framework for Implementation Research;cost;Cost Analysis;Cost Effectiveness Analysis;Data;Data Analyses;design;Development;Diagnosis;Disparity;Dissemination and Implementation;dissemination research;Education;Effectiveness;elementary school;Emergency department visit;Ensure;evidence base;evidence based guidelines;experience;Face;Fostering;Foundations;Funding;Future;future implementation;Goals;Guidelines;Health;health disparity;High Prevalence;Home;hospitalization rates;implementation evaluation;implementation research;implementation science;improved;improved outcome;Individual;innovation;Intervention;K-Series Research Career Programs;Knowledge;Literature;Low income;Low Income Population;medication administration;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Minority;Modeling;Morbidity - disease rate;National Heart, Lung, and Blood Institute;novel;Outcome;Parents;patient oriented;Patient-Focused Outcomes;Patients;Policies;Population Heterogeneity;Positioning Attribute;Prevalence;Prevention;Process;program dissemination;programs;Quality of life;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;recruit;Reporting;Research;Research Methodology;Research Personnel;Role;school district;Schools;Self Efficacy;Site;societal costs;stakeholder perspectives;Statistical Data Interpretation;Students;Symptoms;System;teacher;Training;Translating;Translational Research;Translations;urban school;Work;Youth

PROJECT_TITLE: Chicago Asthma School-Directed Child-Centered Assessment and Dissemination of Evidence (CASCADE) Program

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CLEVELAND STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Telomere proteins are not only essential for genome integrity and cell proliferation in a kinetoplastid parasite Trypanosoma brucei but also regulate antigenic variation, a key pathogenesis mechanism enabling T. brucei to establish a long-term infection. Importantly, T. brucei uses PolIE, a novel telomere protein and an A family DNA polymerase, to coordinate telomere G- and C-strand DNA syntheses, which is completely different from that in higher eukaryotes where OB fold-containing telomere ssDNA binding factors regulate the telomere end processing. In this project, we will investigate the mechanisms of T. brucei telomere end processing and its regulation, which will not only greatly improve our understanding about telomere protein evolution but also contribute to future development of anti-parasite agents.

PI_NAMEs: LI, BIBO  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Affect;African Trypanosomiasis;Antigenic Variation;Binding;Binding Proteins;Biological Assay;Biology;Cell Proliferation;Cells;Chromosomes;Complex;Development;DNA;DNA biosynthesis;DNA polymerase alpha-primase;DNA Primase;DNA Repair;DNA Repair Pathway;DNA-Directed DNA Polymerase;Ensure;Eukaryota;Eukaryotic Cell;Evolution;Excision;EXO1 gene;Exonuclease;Family;Future;Generations;Genetic Recombination;genome integrity;Goals;homologous recombination;Human;Immune Evasion;Immune response;improved;Infection;Knowledge;Label;Length;Ligation;Maintenance;Mediating;mutant;Nonhomologous DNA End Joining;novel;nuclease;Nucleotides;Oligonucleotides;Organism;Parasites;Pathogenesis;Play;Polymerase;Process;Proliferating;Proteins;recruit;Regulation;Resected;Role;Single-Stranded DNA;Structure;Surface Antigens;Telomerase;telomere;Telomere Maintenance;Telomere Pathway;Telomere Recombination;Testing;Trypanosoma;Trypanosoma brucei brucei

PROJECT_TITLE: Telomere end processing and telomere stability maintenance in trypanosomes

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Epilepsy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_DEPT: NEUROSURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Patients with glioma often have seizures, a neurological condition that greatly reduces quality of life. A specific genetic mutation in the glioma cells, involving isocitrate dehydrogenase 1, predisposes patients to seizures. The work proposed here is aimed at understanding why this tumor mutation causes seizures, and how to better control these seizures in glioma patients.

PI_NAMEs: HORBINSKI, CRAIG MICHAEL (contact);SWANSON, GEOFFREY T

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;Adult;Affect;Agonist;Alzheimer's Disease;analog;antagonist;anti-epileptic agents;Anxiety;Behavior;Binding;Brain;Brain Neoplasms;brain tissue;Cells;Characteristics;Chemicals;Clinical;Clinical Trials;Coculture Techniques;comparison control;Data;Disease;DNA Sequence Alteration;efficacy evaluation;Electroencephalography;Engineering;Engraftment;Enzyme Inhibitor Drugs;Epilepsy;epileptiform;Excitatory Amino Acid Transporter 2;excitatory amino acid transporter 3;excitotoxicity;experience;Extracellular Space;Fostering;Generations;Genes;Genomics;Genotype;Glioblastoma;Glioma;Glutamate Transporter;Glutamates;Hippocampus;Immunohistochemistry;improved;In Vitro;in vivo;Incidence;Inflammation;inhibitor;Isocitrate Dehydrogenase;Keppra;Left;Levetiracetam;Life;Link;Mass Spectrum Analysis;Memantine;Membrane;Memory Loss;Metabolic;Methods;Molecular;multi-electrode arrays;Mus;Mutation;N-Methyl-D-Aspartate Receptors;neural;Neurologic;neuron loss;Neurons;Neurotransmitters;new therapeutic target;next generation;NMDA receptor antagonist;Oranges;Oxidative Stress;patch clamp;Pathologic;patient population;Patients;Persons;Pharmaceutical Preparations;pharmacologic;postsynaptic;Predisposition;Preparation;prevent;Primary Brain Neoplasms;Production;Proteomics;Publishing;Quality of life;receptor;Receptor Down-Regulation;receptor downregulation;Receptor Inhibition;reuptake;Risk;Seizures;side effect;Sleeping Beauty;Slice;success;Synaptic Cleft;Testing;Time;Tissues;transcriptome sequencing;Transposase;tumor;United States;Work;World Health Organization

PROJECT_TITLE: Targeting IDH mutations to improve seizure control in glioma patients


PI_NAMEs: LIACHKO, NICOLE FARON (contact)

PROJECT_TERMS: Applications Grants;Area;cellular imaging;Clinical;Clinical Pathology;Collaborations;comparative;Comparative Pathology;Consultations;Core Facility;cost effective;Data;Development;Diabetes Mellitus;Disease;Ensure;Equipment;experimental study;fluorescence imaging;Fluorescence Microscopy;Fostering;Funding;Goals;Growth;high standard;Histocytochemistry;Human Resources;Image;Image Analysis;imaging system;Imaging Techniques;Immunohistochemistry;innovation;Institution;instrumentation;Investigation;laser capture microdissection;Leadership;Manuscripts;Methodology;microscopic imaging;Microtomy;molecular imaging;Morphology;Pathologist;Peer Review Grants;preclinical study;Productivity;Protocols documentation;Publishing;Quality Control;Quantitative Microscopy;Reagent;Reproducibility;Research;Research Design;Research Personnel;Scanning;Services;superresolution microscopy;System;Techniques;Tissue imaging;tissue processing;Tissue Stains;Tissues;Training;Universities;Update;Washington;Work

PROJECT_TITLE: CELLULAR AND MOLECULAR IMAGING CORE


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Endocrine Disruptors;Mental Health;Neurosciences;Pediatric

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project narrative Pregnant women and children are exposed to a mixture of chemicals. We will investigate the impact of prenatal and postnatal exposures to chemical mixtures on child cognition, attention/executive function, externalizing and internalizing behaviors, and brain imaging. We will use two well-characterized birth cohort studies in the U.S. and Canada to identify the impact of a single chemical, interactions between chemicals, and joint effect of multiple chemicals.

PI_NAMEs: CHEN, AIMIN  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 12 year old;adverse birth outcomes;Affect;Age;Air;American;Anatomy;Anxiety;Arsenic;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;behavioral outcome;Biological Markers;Birth;bisphenol A;Brain;Brain imaging;Cadmium;Calcium Signaling;Canada;Central Nervous System;chemical association;Chemicals;Child;Child Development;Chlorinated Hydrocarbons;Chlorpyrifos;Cognition;cognitive ability;cognitive function;cohort;Cohort Studies;Conduct Disorder;Data;design;Development;developmental neurotoxicity;dichlorodiphenyltrichloroethane;Diet;Dust;Elasticity;Endocrine Disruptors;Environment;environmental chemical;Environmental Epidemiology;Environmental Health;Environmental Pollutants;epidemiology study;Epigenetic Process;executive function;Exposure to;Fetal Development;Flame Retardants;Fluorides;follow-up;Health;Heavy Metals;Height;Human Milk;Individual;Infant;Investigation;Joints;Lead;Learning;Learning Disabilities;Least-Squares Analysis;Life;Literature;Manganese;Measures;Mediation;Mental Depression;Mercury;Metals;Methods;Methylmercury Compounds;migration;myelination;National Health and Nutrition Examination Survey;neural network;neurobehavior;neurobehavioral;neurochemistry;neurodevelopment;neuroimaging;Neurons;Neurosecretory Systems;Neurotoxins;neurotransmitter release;neurotransmitter uptake;Neurotransmitters;organochlorine pesticide;Organophosphates;Outcome;Oxidative Stress;Parabens;persistent organic pollutants;Pesticides;Phenols;phthalates;Placenta;Policy Making;Poly-fluoroalkyl substances;polybrominated diphenyl ether;Polychlorinated Biphenyls;postnatal;Predisposition;Pregnancy;Pregnant Women;prenatal;prenatal exposure;Problem behavior;Proliferating;Prospective cohort;pyrethroid;Research;sex;Statistical Methods;Structure;Synapses;Testing;Tetrachloroethylene;Tobacco smoke;Toluene;Toxicant exposure;Triclosan;Water;white matter

PROJECT_TITLE: Impact of pre- and postnatal chemical mixture exposures on child neurobehavior and neuroimaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-K(02)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE Transcriptional profiling of Pancreatic ductal adenocarcinoma (PDA) patient specimens recently identified two main disease subtypes termed Classical and Basal, with the Basal subtype correlating with increased resistance to chemotherapy, a higher propensity to metastasize and shorter overall survival of patients. We recently identified a master regulator of the Basal subtype of PDA, the GLI2 transcription factor, that drives aggressive features of this disease. Our proposal will determine how GLI2 controls maintenance and induction of Basal identity in two important and clinically relevant contexts: resistance to KRAS* pathway suppression and during metastasis.

PI_NAMEs: PERERA, RUSHIKA MIRIAM (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Address;autocrine;Automobile Driving;Biology;Cancer Etiology;Cell Line;Cells;Cessation of life;chemotherapy;Classification;Clinic;clinically relevant;Coculture Techniques;combat;conditioning;Disease;disorder subtype;effective therapy;Effectiveness;Epithelial Cells;Erinaceidae;gain of function;Gene Expression Profiling;Genetic;Genetic Transcription;GLI2 gene;Goals;Human;human model;in vivo;KRAS2 gene;Ligands;Maintenance;Malignant neoplasm of pancreas;Mediating;Modeling;Molecular;Mus;mutant;Neoplasm Metastasis;neoplastic cell;osteopontin;Outcome;overexpression;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;paracrine;Pathway interactions;Patients;pharmacologic;Phenotype;Primary Neoplasm;Process;Prognosis;programs;Relapse;Resected;Resistance;resistance mechanism;Role;Specimen;targeted treatment;transcription factor;treatment response;tumor;tumor growth;tumor progression;tumorigenic;Up-Regulation;Variant;Western World;Work

PROJECT_TITLE: Identifying Molecular Drivers of Cellular Plasticity in Pancreatic Cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Networking and Information Technology R&D (NITRD);Patient Safety

PHR: Project Narrative Data derived from electronic health records (EHR) provide tremendous opportunities for clinical and translational research. A key challenge remains that the reproducibility of findings across studies is limited, which raised a fundamental concern on the value of these researching findings. The overarching goal of this proposal is to develop a rigorous bias correction tool through modern knowledge engineering and data-driven statistical modeling, for enhancing the reproducibility of EHR-based clinical findings.

PI_NAMEs: CHEN, YONG  (contact);XU, HUA

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Adverse event;Algorithms;Cations;Chronic;Clinical;Clinical Investigator;Clinical Research;cohort;Computer software;Data;Data Science;Data Set;EHR research;Electronic Health Record;Engineering;Evaluation;Failure;Feasibility Studies;Goals;Health;health data;Health system;high standard;improved;Individual;Informatics;Information Retrieval;Investigation;Joints;Knowledge;Knowledge Discovery;Measurement;Medical;Methodology;Methods;Modeling;Modernization;multiple datasets;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Paper;Patients;Pennsylvania;Phenotype;phenotyping algorithm;Pilot Projects;Population;Procedures;Publishing;Reproducibility;Reproducibility of Results;Research;Research Personnel;response;Risk Factors;Sampling Studies;software development;Statistical Models;System;Texas;tool;Translational Research;Universities;Validation

PROJECT_TITLE: PheBC: bias correction methods for EHR derived phenotype


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: PROJECT NARRATIVE Children born several months before term are at increased risk of developing a devastating disease of the retina (retinopathy of prematurity, ROP) and of longterm adverse visual outcomes (AVO) including blindness. The central goal of our project is to design and plan for a large multi-center cohort study in which the relationship between sociodemographic, biological, and clinical risk factors, and ROP/AVO can be elucidated in detail. The specific aims of the project are (1) to finalize the member list for the study consortium, (2) to develop the study protocol and Manual of Procedures, and (3) to outline and perform preliminary and feasibility studies.

PI_NAMEs: DAMMANN, OLAF  (contact)

PROGRAM_OFFICER_NAME: SHOAIBI, AZADEH

PROJECT_TERMS: Advisory Committees;Area;Artificial Intelligence;Basic Science;Biological;Biological Markers;Birth;Blindness;Brain Injuries;Child;Clinical;Clinical Research;clinical risk;cohort;Cohort Studies;Darkness;Data;Data Analyses;Data Collection;data management;Databases;design;Developmental Disabilities;Disease;Elements;equity, diversity, and inclusion;Etiology;experimental study;Exposure to;extreme prematurity;Extremely low gestational age newborn;Feasibility Studies;follow-up;Funding;Genetic;Goals;high risk;Image;imaging biomarker;Imaging Device;improved;infancy;Infection;innovation;instrument;intraamniotic infection;Laboratories;Legal Blindness;legally blind;Light;Machine Learning;Manuals;Measurement;Measures;Mediator;member;Modeling;Myopia;National Eye Institute;National Institute of Neurological Disorders and Stroke;Neonatal;Neonatal Intensive Care Units;neonatal sepsis;Neonatology;neurovascular;new therapeutic target;novel;Observational Study;Outcome;Outcome Assessment;Oxygen;Parents;Pathogenesis;Physiology;Placenta;Play;postnatal;Pre-Eclampsia;Pregnancy;premature;Premature Infant;prenatal;Procedures;Process;Prospective, cohort study;Protocols documentation;Publications;recruit;Research Design;Research Methodology;Research Personnel;Retinal Diseases;retinal imaging;Retinopathy of Prematurity;Risk;Risk Factors;Risk Reduction;Role;Sepsis;social;social health determinants;sociodemographics;Specificity;Strabismus;Structure;systemic inflammatory response;Testing;Time;United States;United States National Institutes of Health;Visual;Work;working group

PROJECT_TITLE: Planning the VICTORY (VIsual ComplicaTions Of PrematuRitY) Study


PI_NAMEs: BORNFELDT, KARIN E. (contact)

PROJECT_TERMS: adeno-associated viral vector;Animals;Applications Grants;Area;Cell Line;cell type;Cells;Cloning;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complications of Diabetes Mellitus;Consultations;COVID-19 pandemic;CRISPR/Cas technology;Cultured Cells;Development;Diabetes Mellitus;Disease;Funding;Gene Expression;gene repression;Generations;Genetically Engineered Mouse;genome editing;Genotype;Goals;Institution;interest;International;Laboratories;Lentivirus;Lentivirus Vector;Mediating;Methods;Molecular Biology;Monitor;mouse model;Mus;nutrition;Obesity;Peer Review Grants;Preparation;Production;Productivity;programs;promoter;Publications;Reagent;Regenerative Medicine;Research;Research Personnel;Resources;Retroviridae;RNA;Services;Spumavirus;stem cells;Tissues;Training;Transcriptional Activation;Transgenic Mice;Transgenic Organisms;United States National Institutes of Health;Universities;usability;vector;Viral;Viral Vector;Virus;Washington;Work

PROJECT_TITLE: CRISPR, VECTOR AND TRANSGENIC MOUSE CORE


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative This multi-project grant focuses on the causes of severe respiratory tract inflammation that leads to asthma and chronic rhinosinusitis, two closely related, common and debilitating conditions. The knowledge gained should lead to improved diagnostic and treatment options.

PI_NAMEs: BOYCE, JOSHUA A (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Airway Disease;airway inflammation;airway remodeling;Allergic Disease;Animals;aspirin-exacerbated respiratory disease;Asthma;Automobile Driving;Basal Cell;Cell Aging;Cell Differentiation process;Cell Physiology;Cell Proliferation;Cells;Cholesterol Homeostasis;chronic rhinosinusitis;Clinical;Clinical effectiveness;clinical efficacy;Clinical Trials;Collaborations;comparative efficacy;Controlled Clinical Trials;cysteinyl-leukotriene;Cytokine Signaling;Development;Diagnostic;Dinoprostone;Disease;Double-Blind Method;Dysplasia;Effector Cell;Epigenetic Process;Epithelial Cells;epithelial stem cell;Epithelium;Failure;FRAP1 gene;Functional disorder;Funding;Genetic Transcription;Genomics;Grant;Homeostasis;IL6ST gene;Immune;immunopathology;Impairment;imprint;improved;Individual;Inflammatory;Interleukin 4 Receptor;Interleukin-13;Interleukin-4;Interleukin-6;Interleukins;Knowledge;leukemia;LIF gene;Link;Maintenance;Maps;mast cell;mastocytosis;Mediator;Molecular;Nasal Polyps;Nose;notch protein;novel;Pathology;Pharmaceutical Preparations;Phenotype;Placebo Control;placebo controlled trial;polyposis;Population;pressure;Production;programs;Proliferating;Prostaglandin Production;recruit;Recurrence;Research;Research Personnel;respiratory;Respiratory System;restoration;restraint;Role;Signal Transduction;skills;stem cells;Stromal Cells;Syndrome;Testing;Therapeutic;Tissues

PROJECT_TITLE: Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Project Narrative Alzheimer’s disease (AD) is progressive neurodegenerative disease with a complex etiology likely dominated by accumulation of environmental insults. There is increasing data that chronic, age-related inflammation plays an important role in AD progression. We propose to create a more physiologic mouse model to study AD and other neurodegenerative diseases by exposing AD mice to repeated infections to seed the brain with potentially pro- inflammatory tissue resident memory T cells that might alter AD progression.

PI_NAMEs: KAECH, SUSAN M (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: acute infection;adaptive immunity;Affect;Age;age acceleration;age related;age related neurodegeneration;Age-associated memory impairment;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid;Animal Experimentation;Animal Model;Animals;Area;Astrocytes;Brain;brain health;brain tissue;CD8B1 gene;Cell Communication;Cell model;Cells;Central Nervous System;Chronic;Cicatrix;Complex;cytokine;cytotoxic;Data;Dementia;Development;Disease;Disease Progression;Encephalitis;Environment;Environmental Risk Factor;Epigenetic Process;epigenome;epigenomics;Etiology;Exposure to;Genetic;Genetic Predisposition to Disease;Genetic Transcription;germ free condition;Goals;Grant;Health;high reward;high risk;Hippocampus;Housing;Immune;immune cell infiltrate;immune function;Immune response;Immune system;immunological status;Impaired cognition;Individual;Infection;Inflammaging;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Interferon Type II;Interferons;Knowledge;Lead;Link;Long-Term Effects;Macrophage;Memory;Metabolic;Microbe;Microglia;mouse model;Mus;Myeloid Cells;Nerve Degeneration;Neurobiology;Neurodegenerative Disorders;Neuroglia;neuroinflammation;neuron loss;Neurons;novel;pathogen;Pathogenesis;Pathogenicity;Pathologic;Pathology;Peripheral;Phenotype;Physiological;Play;Pre-Clinical Model;Production;protective factors;Reaction;Recording of previous events;Research Personnel;response;Risk;Risk Factors;Role;Source;stem;Sterility;Symptoms;T cell infiltration;T memory cell;T-Cell Receptor;T-Lymphocyte;tau Proteins;Testing;Time;tissue resident memory T cell;Tissues;Viral;Virus Diseases;Work

PROJECT_TITLE: Infectious history as a determinant of age-related inflammation in Alzheimers disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Z(55)R]


NIH_SPENDING_CATS: Asthma;Lung

PROJECT_TERMS: Animals;aspirin-exacerbated respiratory disease;Documentation;Funding Opportunities;Human;Human Resources;human subject;Individual;innovation;Institution;Manuscripts;meetings;Notification;Preparation;Principal Investigator;Progress Reports;Protocols documentation;Research;Schedule;Services;Specific qualifier value;symposium;Therapeutic;Training;Travel

PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Asthma;Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Lung;Networking and Information Technology R&D (NITRD)

PI_NAMEs: RAYCHAUDHURI, SOUMYA  (contact)

PROJECT_TERMS: Acceleration;Algorithms;Allergic Disease;analytical tool;Archives;aspirin-exacerbated respiratory disease;Asthma;ATAC-seq;Automobile Driving;Basal Cell;Bioinformatics;Biological Response Modifier Therapy;Cell Aging;Cell Differentiation process;cell type;Cells;Cellular biology;Chromatin;chromatin remodeling;chronic rhinosinusitis;Clinical Trials;Computational Biology;Computing Methodologies;Data;Data Analytics;data integration;Data Science;Data Set;Development;Dimensions;Discriminant Analysis;Disease;epigenome;epigenomics;Epithelium;Event;experience;experimental study;firewall;functional genomics;Gene Expression;Genetic Transcription;Genomic approach;Genomics;Goals;Grant;Heterogeneity;High Performance Computing;Hospitals;Human Resources;Immune;immunopathology;Individual;informatics infrastructure;insight;Interleukin-13;Interleukin-4;large datasets;large scale data;mast cell;Mediating;Medical;medical schools;Methods;Modeling;Molecular;Morphologic artifacts;multiple omics;Nasal Polyps;National Institute of Allergy and Infectious Disease;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Nose;Occupations;Pathway interactions;Patients;Pharmaceutical Preparations;polyposis;Population;Positioning Attribute;Procedures;Process;programs;Proteins;Proteomics;Reproducibility;Research;Research Personnel;Research Project Grants;response;Rheumatoid Arthritis;RNA;Running;Sampling;Series;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Statistical Data Interpretation;Statistical Methods;stem cell population;success;synergism;Systemic Lupus Erythematosus;Systems Biology;targeted treatment;Technology;terabyte;Testing;Therapeutic;Tissue-Specific Gene Expression;transcriptome;transcriptome sequencing;transcriptomics;Tuberculosis;Woman;Work

PROJECT_TITLE: Core B: Integrative Genomics Core


PROJECT_TERMS: 3-Dimensional;Adult;airway obstruction;Anatomy;Aspirin;aspirin-exacerbated respiratory disease;Asthma;Automobile Driving;Cell Communication;Cell Count;Cell Physiology;Cell Proliferation;Cells;Characteristics;chronic rhinosinusitis;Chymase;Collaborations;Consumption;Cues;cyclooxygenase 1;cytokine;Cytokine Signaling;Data;Development;Diagnostic;Dinoprostone;Disease;Effector Cell;Eosinophilia;Epithelium;Ethics;Fibroblasts;Functional disorder;Genetic Transcription;Goals;Health Expenditures;Heterogeneity;Homeostasis;Human;IgE;IL6ST gene;Immune;Immune response;immunopathology;in vivo;Individual;Interleukin 4 Receptor;Interleukin-6;leukemia;Lipids;Maps;mast cell;mastocytosis;Mediator;Molecular;Mucous Membrane;Nasal Polyps;Nose;novel;Obstruction;Onset of illness;Organ;Pathogenesis;Pathway Analysis;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;polyposis;Population;programs;Proliferating;Proliferation Marker;Reaction;recruit;Regulation;respiratory;Respiratory Disease;Respiratory System;Respiratory Tract Diseases;Role;Signal Transduction;stem cells;Stromal Cells;System;Testing;Therapeutic;therapeutic target;Tissues;Tryptase;Tumorigenicity

PROJECT_TITLE: Project 1.  Regulation of Mast Cell Homeostasis in Type 2 Immunopathology


PI_NAMEs: ZRAIKA, SAKENEH  (contact)

PROJECT_TERMS: Adipocytes;Affect;analytical tool;Animals;base;Brain;Catheterization;Cell Physiology;Cell Survival;cell type;Cells;Chronic;Closure by clamp;Communities;Conscious;Consultations;Continuous Glucose Monitor;Data;Dependovirus;design;Detection;Diabetes Mellitus;Disease;Endothelial Cells;experience;Funding;Genus Hippocampus;Glucose Clamp;glucose metabolism;glucose tolerance;Glycolysis;Goals;Harvest;Health Services Accessibility;Hepatocyte;Hormones;Human;Human Resources;Hyperinsulinism;Implant;In Vitro;in vivo;in vivo evaluation;Infusion procedures;Insulin Resistance;islet;Islet Cell;Islets of Langerhans Transplantation;Leadership;Liver;Lymphocyte;Macrophage;Manuscripts;Measurement;Measures;Metabolic;metabolic abnormality assessment;metabolic phenotype;Metabolism;Methods;minimally invasive;Mitochondria;Morphology;Muscle Fibers;Neurons;nutrition;Obesity;Oxygen Consumption;Pacific Northwest;Pancreatic duct;Peer Review Grants;Peptides;Performance;PET/CT scan;Phenotype;Physiological;Physiological Processes;Positron-Emission Tomography;Process;Production;Publications;Quality Control;Regulation;Research;Research Personnel;Research Support;response;Retina;Rodent;Rodent Model;Role;Sampling;Services;Signal Transduction;skills;stem cells;Stress;System;temporal measurement;Testing;Time;Tissues;tool;Training;Universities;Washington;Work

PROJECT_TITLE: METABOLIC AND CELLULAR PHENOTYPING CORE


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Complementary and Integrative Health;Natural Products

ORG_DEPT: DENTISTRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative This project is focused on the identification of novel intracellular inputs to stress-activated signaling pathways. These inputs are critical to elicit the normal cellular responses to a wide variety of chemical and physical stress conditions, including heat shock, environmental toxins, and genotoxic stress. Such cellular responses help to maintain cellular integrity, metabolism, and genomic stability and are important in the treatment and prevention of cancer and other diseases.

PI_NAMEs: LEVIN, DAVID E. (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Acetic Acids;acid stress;Address;Alzheimer's disease therapeutic;Arsenites;Automobile Driving;Biochemical;cancer prevention;Cell surface;Cell Wall;Cells;Chemicals;Clinical Trials;Curcumin;Data;Disease;DNA Damage;DNA damage checkpoint;endoplasmic reticulum stress;Environment;Evolution;Funding;Genetic;genetic approach;Genetic Screening;Genome Stability;Genotoxic Stress;Glycerol;Growth;Heat-Shock Response;Histidine;insight;interest;Malignant Neoplasms;MAP3K1 gene;MEKKs;MEKs;Metabolism;Modeling;Nature;novel;Osmolar Concentration;Osmosis;Output;Oxidative Stress;Pathway interactions;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;protein degradation;Protein phosphatase;Proteins;recruit;response;Role;Route;Saccharomyces cerevisiae;Scaffolding Protein;shear stress;Signal Pathway;Signal Transduction;Spices;Stress;stress activated protein kinase;stressor;Toxic Environmental Substances;Toxin;Tumeric;upstream kinase;Yeasts

PROJECT_TITLE: Intracellular Stress Inputs to SAPK Signaling Pathways

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Diversity and inclusion are crucial for the discovery and development of more effective detection and treatment of cardiovascular, pulmonary and hematological disorders. This grant seeks to address this issue by providing training opportunities in the areas relevant to the interests of NHLBI for college students with limited access to research and/or from underrepresented groups.

PI_NAMEs: VELEZ-RUIZ, GISSELLE A (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Address;Advertisements;Area;biological research;Biological Sciences;Biomedical Research;Cardiovascular Diseases;career;Career Choice;career development;Career Exploration;career networking;Cognitive;college;Communication;Communities;Competence;Data Analyses;Detection;Development;Directories;diversity and inclusion;Doctor of Philosophy;Doctor's Degree;Educational process of instructing;Educational workshop;Electronic Mail;experience;Experimental Designs;Exposure to;Faculty;faculty research;follow-up;Funding;Goals;graduate student;Grant;Health;Hematological Disease;improved;interest;Knowledge;Laboratories;Laboratory Research;Leadership;Letters;Literature;Lung Diseases;Medical;medical schools;Medical Students;member;Mentors;Minority;minority undergraduate;National Heart, Lung, and Blood Institute;Nature;Newsletter;Oral;Preparation;Printing;Program Appropriateness;programs;Reading;recruit;Research;Research Ethics;Research Project Grants;Research Technics;responsible research conduct;role model;Science;skills;Student Selections;Students;success;summer research;symposium;teacher;Telephone;Training;training opportunity;undergraduate research experience;undergraduate student;Underrepresented Populations;university student;Update;Visit;Writing

PROJECT_TITLE: NHLBI Summer Training Experience to Increase Diversity in Health-Related Research


ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: OVERALL PROJECT NARRATIVE Enteric and respiratory infectious diseases are a leading cause of worldwide morbidity and mortality. This project uses increasingly complex human organoid cultures with enhanced engineering features to generate more representative physiologic systems to understand the molecular and cellular drivers of infections caused by enteric and respiratory viruses and bacteria.

PI_NAMEs: ESTES, MARY KOLB (contact);MARESSO, ANTHONY W;PIEDRA, PEDRO A

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Address;Animal Model;Apical;Autologous;Bacteria;Bacterial Infections;Bacteriology;Bacteriophages;Basic Science;Biocompatible Materials;Biological Models;biomaterial development;Biomechanics;Biomedical Engineering;Biomimetics;Body System;Cancer Center;Cell model;Cells;Cellular biology;Clinical Microbiology;co-infection;Coculture Techniques;college;commensal bacteria;Communicable Diseases;Communities;Complex;Coronavirus Infections;Cues;Development;Developmental Biology;Developmental Cell Biology;Disease;Engineering;Enteral;enteric infection;enteric virus infection;enteroaggregative Escherichia coli;Epithelium;expectation;fluid flow;Functional disorder;Funding;gastrointestinal infection;Gastrointestinal tract structure;Genetic;genetic manipulation;Genomics;Glycobiology;Goals;gut-lung axis;host-microbe interactions;Human;Human Biology;human coronavirus;human disease;human model;Immune;Immune response;Immunology;Infection;Infectious Diseases Research;innovation;Institution;Intestinal Mucosa;Intestines;Investigational Drugs;Knowledge;Laboratory Study;Lung;Medical center;Medicine;Methods;Microbe;microbial;microbiome;microorganism;Modeling;Molecular;Morbidity - disease rate;mortality;Mucous Membrane;multidisciplinary;Neurons;next generation;Norovirus;Nose;novel;Organ;Organoids;Outcome;Oxygen;pathogen;Pathogenesis;Physicians;physiologic model;Physiological;Physiological Processes;Physiology;Polysaccharides;Population Heterogeneity;pre-clinical;Pre-Clinical Model;preclinical study;Predisposition;prevent;Productivity;Property;prophylactic;Proxy;Publications;Request for Applications;Research;Research Personnel;respiratory;respiratory infection virus;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Tract Infections;respiratory virus;response;Rice;Role;Rotavirus;Scientist;sex;shear stress;Site;stem cell biology;success;Surface;synergism;System;Technology;Testing;Texas;Therapeutic;Tissue Engineering;Tissues;Translating;translational approach;Translational Research;Universities;Variant;virology;Virus;Virus Diseases;Work

PROJECT_TITLE: Human Biomimetics for Mucosal Infections


NIH_SPENDING_CATS: Asthma;Lung;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: BARRETT, NORA AMANDA (contact)

PROJECT_TERMS: Airway Disease;airway epithelium;airway inflammation;aspirin-exacerbated respiratory disease;Asthma;Automobile Driving;Basal Cell;beta-Galactosidase;Biological Assay;Bronchiectasis;Cell Adhesion Molecules;Cell Aging;Cell Differentiation process;Cell Physiology;Cellular Assay;Cellular Metabolic Process;Chromatin Structure;Chronic Obstructive Pulmonary Disease;chronic rhinosinusitis;Communities;cytokine;Data;Development;Dinoprostone;Disease;Dysplasia;Eczema;Eosinophilic Esophagitis;Epigenetic Process;Epithelial Cells;epithelial stem cell;Epithelium;Failure;FDA approved;Food Hypersensitivity;FRAP1 gene;Funding;Generations;Genes;genetic signature;Genetic Transcription;genome wide association study;Goals;Homeostasis;Human;Hypertrophy;Immune;immunopathology;imprint;Inflammatory;Interleukin 4 Receptor;Interleukin-13;Interleukin-4;Interleukins;Interruption;long-term sequelae;Maintenance;Mediator;Metabolic;Metabolic Pathway;Metabolism;Molecular;mouse model;Mus;Nasal Polyps;Nose;Pathogenesis;Pathway interactions;Patients;polyposis;Polyps;prevent;programs;Proliferating;Recurrent disease;Relapse;Reporting;Research;Resources;respiratory;response;restraint;Role;senescence;Signal Transduction;Site;stem;stem cell function;stem cell population;stem cells;Therapeutic;Tissues;Transcript;transcriptomics;TSLP gene;wound healing

PROJECT_TITLE: Project 2. Basal Cell Dysplasia in Type 2 Immunopathology


NIH_SPENDING_CATS: Biotechnology;Diabetes

PI_NAMEs: VAISAR, TOMAS  (contact)

PROJECT_TERMS: Address;Adipocytes;analytical tool;Animals;Antibodies;Basic Science;Bioinformatics;Biological Assay;Body Fluids;Cell Separation;Cells;Clinical;Clinical Research;complex data;cost;cost effectiveness;Data;Data Analyses;Data Set;data sharing;Data Storage and Retrieval;Development;Diabetes Mellitus;diabetes pathogenesis;differential expression;Disease;Ensure;experience;Experimental Designs;Flow Cytometry;Functional disorder;Funding;Genes;Goals;Human;Human Resources;Individual;insight;instrument;instrumentation;interest;islet;Isotopes;Label;Laboratories;laser capture microdissection;Lipoproteins;Liquid Chromatography;Macrophage;Mass Spectrum Analysis;Methods;Modernization;Molecular;Monitor;novel;Ontology;Pathway Analysis;Pathway interactions;phenotypic data;Plasma;Preparation;Procedures;Process;Protein Analysis;protein complex;protein protein interaction;Proteins;Proteome;Proteomics;Reaction;Research;Research Personnel;Research Support;Risk Factors;Sampling;Services;Shotguns;single-cell RNA sequencing;Standardization;Systems Biology;tandem mass spectrometry;Techniques;Technology;Tissues;tool;Training;transcriptome sequencing;transcriptomics;translational study;Universities;Urine;Washington

PROJECT_TITLE: PROTEOMICS AND BIOINFORMATICS CORE


NIH_SPENDING_CATS: Asthma;Clinical Research;Lung

ORG_CITY: MAYWOOD

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: Project Narrative Allergic asthma is a chronic inflammatory disease of the lungs without cure. Repetitive allergen exposure in the airway leads to the generation of pathogenic immune memory and the excessive production of allergen specific IgE antibodies that mediate inflammation in the airway. In this proposal, we probe the development of memory B cells (MBCs) in allergic lungs and their systemic dissemination to understand the characteristics of pathogenic MBCs as well as test strategies to intercept the systemic dissemination of pathogenic MBCs to halt the progression of allergic inflammation.

PI_NAMEs: WU, YEE LING (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Address;Affinity;Agonist;Airway Disease;Allergens;Allergic;Allergic inflammation;Anatomy;anti-CD20;Antibodies;Antibody Affinity;Antibody Formation;Antibody Response;Antigens;B cell repertoire;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;Bacterial Infections;Biology;CCL20 gene;CCR6 gene;Cell Adhesion Molecules;Cells;Characteristics;chemokine receptor;chronic inflammatory disease;chronic inflammatory lung disease;Circulation;constriction;Development;Disease Progression;Effector Cell;experimental study;Exposure to;Extrinsic asthma;Gene Expression Profile;Generations;Genetic Transcription;Goals;Heterogeneity;Homing;Human;IgE;IgG1;immune function;Immune response;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin M;Immunoglobulin-Secreting Cells;Immunologic Memory;Infection;Inflammation;Intercept;Lung;lymphoid organ;lymphoid structures;Lymphoid Tissue;Mediating;Memory B-Lymphocyte;Microscopy;mouse model;Mucous Membrane;Mus;novel therapeutic intervention;Output;Parabiosis;Pathogenicity;Patients;Phenotype;Plasma Cells;Population;Positioning Attribute;Prevalence;Production;Pulmonary Inflammation;Respiratory distress;response;sensitizing antigen;Signal Transduction;Site;Spleen;Structure of germinal center of lymph node;Testing;Tissues;trafficking;transcriptomics;Virus Diseases

PROJECT_TITLE: Development of B cell memory in allergic asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Aging

PHR: PROJECT NARRATIVE This program trains exceptional predoctoral and postdoctoral students as researchers in the demography and economics of aging. These trainees will use innovative methods in social science research and produce, over their careers, research findings directly relevant to public policy and public health, and will focus on such topics as demographic change, inequality over the life course, mental health, access to health services, and health disparities.

PI_NAMEs: MELTZER, DAVID O (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Aging;Demography;Economics;Training

PROJECT_TITLE: Specialized Training: Demography and Economics of Aging - Renewal 01 - Renewal


NIH_SPENDING_CATS: Asthma;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Lung

PI_NAMEs: LAIDLAW, TANYA MARIA (contact)

PROJECT_TERMS: Address;Adult;Affect;airway inflammation;Anosmia;antagonist;aspirin-exacerbated respiratory disease;Asthma;Automobile Driving;Biological;Biological Products;Biological Response Modifier Therapy;Biology;Cell Aging;Cells;cellular targeting;Chronic;chronic rhinosinusitis;Clinical;Clinical effectiveness;clinical efficacy;cohort;comparative efficacy;Controlled Clinical Trials;cysteinyl-leukotriene;cytokine;cytokine therapy;Data;Diagnosis;Dinoprostone;Disease;Double-Blind Method;effective therapy;Effector Cell;Epithelial Cells;experience;FDA approved;Functional disorder;Growth;Histology;Impairment;improved;Inflammation;Inflammatory;inhibitor;innovation;Interleukin-13;Interleukin-4;Interruption;Intervention Studies;Learning;Link;mast cell;mastocytosis;Mediator;Nasal Polyps;Nose;novel;Outcome Measure;Pain;Pathway interactions;Patient Agents;Patients;Pharmaceutical Preparations;Placebo Control;Play;polyposis;Polyps;Production;Prostaglandin Production;Recurrence;respiratory;Role;Severities;Signal Transduction;Sinus;Smell Perception;Symptoms;Syndrome;Testing;Therapeutic;Therapeutic Effect;therapeutic target;therapy outcome;Tissues;Treatment Efficacy;trial design;Tumorigenicity;Work

PROJECT_TITLE: Project 3. Mechanisms of benefit of biologic agents for patients with aspirin-exacerbated respiratory disease (AERD)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Prevention;Substance Misuse;Substance Misuse Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Basic scientists have many discoveries that could benefit the prevention and treatment of substance abuse, but they are generally not trained in how to commercialize their research. This training program will rely on years of experience to train basic scientists to think like entrepreneurs and award them with a Certificate of Entrepreneurship. All materials will be available to interested trainees and together we will work to improve the care of our patients.

PI_NAMEs: DUNN, KELLY E;PHAN, PHILLIP  (contact)

PROGRAM_OFFICER_NAME: LUKACS, JESSICA MICHELLE

PROJECT_TERMS: Active Learning;Address;Advocate;Award;Basic Science;Businesses;career;Caring;certificate program;Clinic;Clinical;clinical practice;Clinical Sciences;Clinical Treatment;commercialization;Communities;community building;design;Diagnosis;Disabled Persons;Education;education resources;Educational Curriculum;Educational process of instructing;Educational workshop;empowerment;Enrollment;Ensure;Entrepreneurship;Evaluation;evidence base;experience;Exposure to;Feedback;Fostering;Funding;Future;Generations;Goals;Grant;Health;ideation;improved;Individual;innovation;Instruction;instructor;Intellectual Property;interest;Knowledge;Learning;Legal patent;Licensing;Marketing;Measures;meetings;Mentors;Modeling;next generation;online community;Participant;Pathway interactions;Patient Recruitments;Patients;Persons;Population;Positioning Attribute;Prevention;Problem Solving;Process;Professional Education;programs;prototype;Provider;Public Health;recruit;Recruitment Activity;Research;Research Personnel;Resource Sharing;Resources;role model;satisfaction;scaffold;Schools;Science;Scientist;service providers;skills training;stem;substance abuse prevention;substance abuse treatment;Substance Use Disorder;substance use treatment;synchronous contact;Time;tool;Training;Training Programs;Translations;Underrepresented Populations;Universities;virtual;Work

PROJECT_TITLE: Discovery to Commercialization Program for Substance Abuse Prevention and Treatment (D2C: SAPT)


NIH_SPENDING_CATS: Clinical Research;Diabetes

ORG_NAME: UNIVERSITY OF WASHINGTON

PROJECT_TERMS: Area;Award;Behavioral;career development;Clinical;Development;Diabetes Mellitus;Disease;Faculty;feasibility research;Fellowship;Female;Fostering;Funding;Goals;graduate student;Grant;high risk;innovation;Laboratories;Mentors;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Obesity;Peer Review;Pilot Projects;post-doctoral training;Postdoctoral Fellow;programs;Publications;Qualifying;Research;Research Personnel;Research Project Grants;Research Support;Resources;retention rate;Services;success;Time;Training;Underrepresented Minority;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: P&F Program


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative We propose to study risk factors for Alzheimer’s disease and related dementias (AD/ADRD) in the Kenya Life Panel Survey (KLPS), a unique, richly phenotyped cohort of Kenyan adults who have been followed since childhood, and who were participants in a randomized child health intervention (school-based deworming). This project proposes an additional field interview, the KLPS Round 5 Aging Module (KLPS-5A) (when participants will be 35 to 43 years old) to collect detailed “midlife baseline” cognition and aging-related health data (including biomarkers), and information on AD/ADRD risk factors, where a novel aspect is the ability to link these midlife measures to rich existing longitudinal data from childhood and early adulthood, including on cognitive performance. Another notable feature is the ability to utilize experimental variation from the randomized child deworming program, which has been documented to meaningfully affect adult living standards as well as several risk factors for dementia, to better understand pathways over the life course and the scope for public health interventions to reduce AD/ADRD risk.

PI_NAMEs: MIGUEL, EDWARD ANDREW (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: achievement test;Adult;Affect;Africa South of the Sahara;African;Aftercare;Age;Aging;aging population;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Attitude;Back;behavioral outcome;Biological Assay;Biological Markers;Blood;Characteristics;Child;Child Health;Childhood;Cognition;Cognitive;cognitive performance;cognitive testing;cohort;Data;Data Collection;Data Set;Dementia;dementia risk;design;diabetes control;Diabetes Mellitus;Diagnosis;disability;Disadvantaged;Discipline;drinking;Dryness;economic outcome;Education;emerging adult;executive function;field survey;Freezing;Funding;Future;Genetic Markers;Hand Strength;Health;Health behavior;health data;Health Status;human old age (65+);Hypertension;Impaired cognition;Individual;Inflammation;instrumental activity of daily living;Intervention;Interview;Kenya;Language;late life;Life;Life Cycle Stages;Link;Literature;Living Standards;Marketing;Measurement;Measures;Memory;Mental Depression;Mental Health;mental state;middle age;migration;National Institute of Child Health and Human Development;novel;Nutritional;Obesity;Occupational;Occupations;Outcome;Participant;Pathway interactions;Patient Self-Report;Pharmaceutical Preparations;Phenotype;Physical activity;physical conditioning;Predictive Factor;Prevalence;Primary Schools;programs;Protocols documentation;public health intervention;Random Allocation;Randomized;Recording of previous events;Research Personnel;Respondent;Risk Factors;Sampling;Schools;sleep pattern;Smoking;social;social contact;Social Interaction;sociodemographics;Socioeconomic Status;Spottings;Stress;study population;Surveys;Testing;Time;Uncertainty;Validation;Variant;Visuospatial;Work;young adult

PROJECT_TITLE: Measurement and Analysis of Aging, Cognition and Alzheimer's Disease and Related Dementia (ADRD) Risk Factors at Midlife in the Kenya Life Panel Survey (KLPS)

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Autoimmune Disease;Complementary and Integrative Health;Diabetes;Digestive Diseases;Infectious Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition;Obesity;Prevention

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Extra-intestinal manifestations, including insulin resistance, lipid abnormalities and diabetes can occur in 25- 40% of IBD patients, suggesting a link between metabolic defects and chronic intestinal inflammation. Here will test a role for a specific subset of commensal bacteria that might underlie the connection between these diseases.

PI_NAMEs: ROUND, JUNE LOUISE (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: absorption;Adipose tissue;Age;Animals;Bacteria;Binding;CD36 Antigens;CD36 gene;Ceramides;Chronic;Colitis;Collection;commensal bacteria;Communities;Complex;Crohn's disease;Data;Defect;Desulfovibrio;Development;Diabetes Mellitus;Disease;disease model;Disease Progression;experimental study;Germ-Free;Gnotobiotic;gut health;gut homeostasis;gut inflammation;gut microbes;Human;Immune;Immune system;Immunity;Immunoglobulin A;Incidence;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Insulin Resistance;intestinal homeostasis;Intestinal permeability;Intestines;Investigation;Link;Lipids;Maintenance;member;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;Metagenomics;Microbe;microbial;microbial composition;microbial products;microbiota;microbiota composition;microbiota transplantation;microorganism interaction;mouse model;novel;novel marker;Obesity;Oral;Organism;Pathway interactions;Patients;Population;prevent;Prevention;Production;Publishing;Relapse;response;Role;Sampling;Series;sulfate reducing bacteria;Systems Development;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Therapeutic Uses;Ulcerative Colitis;Weight Gain

PROJECT_TITLE: Microbiota-immune interactions that promote intestinal homeostasis

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Heart Disease;Hematology;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Stroke

PHR: Narrative: The proposed research aims to determine the treatment effects, utilization patterns, and potential barriers of transcatheter left atrial appendage occlusion devices and specific oral anticoagulants in persons living with dementia (PLWDs) and atrial fibrillation (AF), and how the net clinical benefits vary by dementia severity, frailty, fall risks, and advanced kidney disease. This study is relevant to public health because it will generate direct benefit-to-risk data to inform optimal stroke prevention strategies in PLWDs with AF. Our study will also produce a novel and generalizable prospective monitoring program for newly marketed medical devices and pharmacotherapies with detailed treatment effect heterogeneity evaluation needed for personalized prescribing decisions.

PI_NAMEs: LIN, JOSHUA K (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adherence;Adopted;Affect;Algorithms;alternative treatment;Alzheimer's disease related dementia;Anticoagulants;Anticoagulation;Atrial Fibrillation;auricular appendage;Calibration;Characteristics;Clinical;Clinical Data;cohort;comparative effectiveness;comparative safety;compare effectiveness;Data;data mining;Databases;Dementia;Detection;Devices;Effectiveness;Elderly;Electronic Health Record;Evaluation;fall risk;Family;Frail Elderly;frailty;Goals;health care service utilization;Hemorrhage;Heterogeneity;high dimensionality;high risk;human old age (65+);Kidney Diseases;Knowledge;Left;Link;Machine Learning;Marketing;Medical Device;Medicare;Medication Errors;medication safety;Methodology;Modality;Monitor;multidimensional data;novel;older adult;older patient;Oral;Patient Preferences;Patients;Pattern;Persons;Pharmacoepidemiology;Pharmacotherapy;Phenotype;phenotyping algorithm;Predictive Value;Prevention strategy;Probability;Procedures;programs;prospective;Proxy;Public Health;Randomized, Controlled Trials;Reporting;Research;Risk;Risk Factors;routine care;Safety;safety outcomes;Selection for Treatments;Severities;Signal Transduction;Stroke;Stroke prevention;Subgroup;Testing;Thrombus;Time trend;tool;treatment effect;Treatment outcome;trend;United States Food and Drug Administration;uptake;vaccine safety;Warfarin

PROJECT_TITLE: Effectiveness and Safety of Transcatheter Left Atrial Appendage Occlusion vs. Anticoagulation in Older Adults with Atrial Fibrillation and Alzheimer's Disease and Related dementias

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Mental Health;Neurodegenerative;Neurosciences;Palliative Care

PHR: Public Health Relevance: Family caregivers of patients with Alzheimer’s disease (AD) frequently experience conflict with the health system when they act as patient advocates (e.g. negotiating treatments, tests, bills), which can cause increased stress, burden, and anxiety. We will tailor, optimize, then pilot test a negotiation and dispute resolutions (NDR) training program, commonly used in business schools, for family caregivers of patients with AD. Teaching NDR to family caregivers has the potential to improve caregiver wellbeing, burden, anxiety, and ultimately improve the care of the adult with AD.

PI_NAMEs: LINDQUIST, LEE A (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Adult;Advocate;Affect;Age;Alzheimer's Disease;Alzheimer's disease caregiver;Alzheimer's disease patient;Ambulatory Care;Anxiety;Area;Back;Businesses;caregiver stress;Caregiver well-being;Caregivers;Caring;Clinical Trials;Communication;Communities;Complex;Conflict (Psychology);Data;Decision Making;design;Disputes;Educational Intervention;Educational process of instructing;empowerment;Ensure;Exercise;experience;Family Caregiver;Feedback;follow-up;Frustration;Future;Goals;Health;Health Personnel;Health Professional;Health system;health training;Helicopter;Home;Hospitalization;Hospitals;Hour;improved;Insurance;Intervention;intervention refinement;Laws;lectures;loved ones;Mediation;Medical Care Team;Medical Students;Moods;multiphase optimization strategy;Nurses;older adult;Online Systems;Outcome;Participant;patient navigator;Patient-Focused Outcomes;Patients;Personal Satisfaction;Pharmaceutical Preparations;Physician Assistants;Physicians;pilot test;pilot trial;Population;post intervention;Prevalence;Process;professor;public health relevance;Public Policy;Randomized;recruit;Research;Resolution;retention rate;Schedule;Schools;skills;Stress;Telephone;Testing;Training;Training Programs;Universities;usability;user centered design;webinar

PROJECT_TITLE: Negotiation Training to Optimize Caregiver Communication in Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-D(56)]


PI_NAMEs: ESTES, MARY KOLB (contact)

PROJECT_TERMS: Accountability;Accounting;Administrator;Annual Reports;Area;Bioinformatics;Biomimetics;Budgets;college;Communicable Diseases;Communication;Communities;computerized;cost;Data;Educational workshop;Ensure;Expenditure;Financial Activity;Funding;Generations;Goals;Grant;Human;Infection;Institutional Review Boards;Intellectual Property;Laboratories;Leadership;Logistics;Maintenance;Manuscripts;material transfer agreement;Medicine;meetings;Microbiology;Molecular Virology;Monitor;Mucous Membrane;National Institute of Allergy and Infectious Disease;Office of Administrative Management;operation;Participant;Piedra;Preparation;programs;Progress Reports;Property Rights;Protocols documentation;Publications;Reagent;Records;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Resource Allocation;Resource Sharing;Rights;Schedule;Scientific Advances and Accomplishments;Services;success;System;Time;Travel;United States National Institutes of Health;webinar

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Over the last several decades, the U.S. Food and Drug Administration (FDA) and pharmaceutical industry have partnered with the U.S. Congress to promote and advance improvements in the efficiency and rigor of drug development and regulatory review. Such collaborative efforts have been established in recurring five-year reauthorizations of the Prescription Drug User Fee Act (PDUFA) and Biosimilar User Fee Act III (BsUFA III). The Robert J. Margolis, MD, Center for Health Policy at Duke University proposes to support the FDA in achieving its PDUFA and BsUFA commitments through rigorous collaborative research and convening activities, building on Duke-Margolis and FDA’s fourteen-year track record of developing and delivering trusted, high-impact stakeholder engagement and research deliverables on priority regulatory and public health issues.

PI_NAMEs: HAMILTON LOPEZ, MARIANNE  (contact)

PROGRAM_OFFICER_NAME: VILLATA, DANIELLE

PROJECT_TITLE: Cooperative Agreement to Support Regulatory Research Related to the 2022 Prescription Drug User Fee Act and Biosimilar User Fee Act (U19)


NIH_SPENDING_CATS: Natural Products;Pain Research

ORG_DEPT: CHEMISTRY

PHR: Project Narrative Finding new and more efficient ways to build complex, bioactive, secondary metabolites (natural products) is important as it may lead to improvements in human health by identifying alternatives to existing medications to address, for example, pain and diseases associated with inflammation. Our goals are to develop new strategies and methods to efficiently construct complex secondary metabolites by functionalizing carbon-hydrogen, carbon-nitrogen and carbon-carbon bonds, which form the core of many organic compounds. Traditionally, these groups have been viewed as inert, especially when they comprise the skeletons of molecules. We will also use carvone, a readily available and sustainable agricultural byproduct, as well as piperidines and heteroaromatics, which are found in many pharmaceuticals and agrochemicals, as starting materials for many of our syntheses. Our efforts will accelerate advances into new chemical space to address human disease.

PI_NAMEs: SARPONG, RICHMOND  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Renewal: Strategies and Methods for Complex Molecule Synthesis

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Eye Disease and Disorders of Vision;Health Services;Patient Safety

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Due to the significant advances in modern cataract surgical technique over the last 30 years, the risk of cataract surgery is now considered low enough that some have questioned the need for anesthesiologists and nurse anesthetists in the operating room to provide continuous intraoperative monitoring and intravenous sedation (a.k.a., “monitored anesthesia care” or “MAC”). However, we do not know which patients would be harmed if anesthesia professionals were removed as a component of routine cataract surgery. This study will help identify high-risk patients who would still benefit from monitored anesthesia care during cataract surgery while creating new knowledge about how best to implement potential changes in the type of sedation offered to patients who are undergoing this procedure.

PI_NAMEs: CHEN, CATHERINE LEE (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: acceptability and feasibility;Adverse event;adverse outcome;Age;Anesthesia procedures;Anesthesiology;Anesthetics;Anxiety;Area;Associate Degree;Biometry;Biostatistical Methods;career;career development;Caring;Case Series;Cataract;Cataract Extraction;Certified registered nurse anesthetist;Characteristics;Complication;cost;Country;Deimplementation;Dementia;design;Development Plans;effectiveness/implementation trial;Elderly;Elements;Evaluation;Event;evidence base;Exposure to;Eye;Foundations;frailty;Frequencies;functional outcomes;Funding;Future;Geriatrics;Gerontology;Goals;Health Services;Health Services Research;Healthcare Systems;high risk;implementation framework;implementation intervention;implementation science;improved;Incidence;Institution;interest;Intervention;Interview;Intraoperative Monitoring;Intravenous;intravenous administration;Intravenous Anesthetics;K-Series Research Career Programs;Knowledge;Measures;medical specialties;Medicare claim;Mentors;Mentorship;Modernization;Monitor;Morbidity - disease rate;mortality;multiple chronic conditions;older adult;Operating Rooms;Operative Surgical Procedures;Ophthalmologist;Ophthalmology;Oral;Outcome;Outcome Study;patient safety;Patients;Perioperative;Perioperative Care;Pilot Projects;Policy Maker;Population;Positioning Attribute;Postoperative Period;preference;preservation;Procedures;Process;Provider;Publishing;Qualitative Research;Quality of life;recruit;Research;Research Methodology;Research Personnel;Resources;Risk;Safety;satisfaction;Sedation procedure;standard of care;Structure;success;surgery outcome;Techniques;Testing;Training;treatment as usual;uptake;Visual impairment;Weight

PROJECT_TITLE: Frailty and Monitored Anesthesia Care for Cataract Surgery in Older Adults

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: DALLAS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Autism spectrum disorders is the most common, heritable, childhood-onset neuropsychiatric disorder. Understanding the genes and molecules critical for normal brain development will provide insight into the etiology of autism and related developmental brain disorders. These proposed studies will identify important genes for brain development and elucidate the functional and mechanistic role of specific genes in cortical development and physiology that can be targeted for the treatment of autism and other neurodevelopmental disorders.

PI_NAMEs: KONOPKA, GENEVIEVE  (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Acute;Affect;Anatomy;autism spectrum disorder;Automobile Driving;Behavior;Behavioral;behavioral phenotyping;Biological Assay;Brain;Brain Diseases;Bromodeoxyuridine;Cell Physiology;cell type;Cells;Childhood;Compensation;conditional knockout;Corpus striatum structure;Data;de novo mutation;Development;developmental disease;Disease;Dopamine Receptor;Electrophysiology (science);Electroporation;Embryo Loss;Etiology;experimental study;Family;FOXP1 gene;FOXP2 gene;functional genomics;functional outcomes;Gene Expression;Genes;Genetic Transcription;genomic data;Goals;Heritability;in utero;Individual;Injections;insight;Intellectual functioning disability;Interneurons;Knockout Mice;Laboratories;Language Disorders;Link;Measurement;member;migration;Molecular;Mutation;Neocortex;neocortical;Neuroanatomy;Neurodevelopmental Disorder;neuronal excitability;Neurons;neuropsychiatric disorder;Normal Cell;Ontology;Pathway interactions;Phenotype;Physiology;postnatal;progenitor;programs;Proliferating;Proteins;Publications;Publishing;Recurrence;Reversal Learning;Risk;risk variant;RNA analysis;Rodent Model;Role;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Slice;social;Specific qualifier value;Speech;synaptic function;Synaptic Transmission;Tamoxifen;targeted treatment;Technology;Testing;Thick;Time;Tissue Harvesting;transcription factor;transcriptome sequencing;Variant;Work

PROJECT_TITLE: Foxp-regulated signaling pathways in brain development


PI_NAMEs: BLUTT, SARAH E (contact)

PROJECT_TERMS: 3-Dimensional;Address;Affect;Animal Model;Antibodies;Architecture;Biological;Biological Models;Biomimetics;Cells;Clinical Trials;Coculture Techniques;Collaborations;Communicable Diseases;Communities;Complex;cost;cost effective;Cost Savings;cytokine;Development;Disease;Elements;Ensure;Environment;Epithelium;Equipment and Supplies;Fluids and Secretions;Functional disorder;Goals;Growth;Health;Homeostasis;Human;Human Activities;Human Resources;human tissue;Immune;Immune response;improved;In Vitro;in vivo;Individual;Infection;Infectious Agent;Infectious Diseases Research;Intestines;Knowledge;Leadership;Learning;Lung;Maintenance;Mechanics;microbiome;microbiome components;microbiome composition;microorganism;mimetics;Modality;Modeling;Mucous body substance;Mucous Membrane;neuron component;Neurons;novel;Organism;Organoids;pathogen;Pathogenesis;Pathogenicity;Physiology;Population;pre-clinical;Pre-Clinical Model;Predisposition;prevent;Prevention;Preventive;Quality Control;Reagent;Reporting;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;response;Services;Signal Transduction;Standardization;Stromal Cells;success;Surface;Technology Transfer;Therapeutic;Time;tissue derived stem cell;Tissue Model;Training;Treatment outcome;Viral Pathogenesis;Work

PROJECT_TITLE: Human Biomimetic Scientific Core


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Schizophrenia

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PUBLIC HEALTH RELEVANCE STATEMENT In this renewal application, we will identify how specific combinations of variants in the genetic background confer risks for distinct developmental, cognitive, and behavioral phenotypes among individuals with the 16p12.1 deletion, ascertained from large families with developmental delay as well as cohorts for schizophrenia, autism, and unselected populations, and compare results with data from cohorts of other rare CNVs such as the 16p11.2 and 15q13.3 deletions. The interactive effects of the 16p12.1 deletion with the genetic background across diverse phenotypic ascertainments will be functionally validated within distinct neuronal subtypes using Drosophila melanogaster models and quantitative neurological assays using zebrafish models. This work will provide a fundamental understanding of the relative effects of common and rare variants towards the clinical outcome of complex disorders, and will develop a novel functional approach to accurately determine the effects of genetic interactions towards neuronal phenotypes.

PI_NAMEs: GIRIRAJAN, SANTHOSH  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: 16p11.2;17p11.2;Affect;autism spectrum disorder;Award;Behavior;Behavioral;behavioral phenotyping;Biological;Biological Assay;Biological Models;Brain;cell type;Child;Chromosome Mapping;Chromosomes;Clinical;Clinical Data;Cognitive;Cognitive deficits;cohort;Complex;Copy Number Polymorphism;Counseling;Data;Defect;Development;Developmental Delay Disorders;Diagnosis;Disease;Disease Outcome;disorder risk;dopaminergic neuron;Drosophila genus;Drosophila melanogaster;Epilepsy;Family;Family history of;follow-up;Frequencies;Funding;Gene Combinations;General Population;Generations;Genes;Genetic;genetic analysis;Genetic Anticipation;genetic approach;genetic disorder diagnosis;genetic variant;Genome;genome sequencing;genomic data;Genomics;Genotype;Goals;Homologous Gene;improved;Individual;Inherited;insight;Intellectual functioning disability;knock-down;Lead;Machine Learning;Maps;Modeling;Mutation;Nature;Nervous System;neuroblast;Neurodevelopmental Disorder;Neurologic;Neurons;neuropsychiatric disorder;neuropsychiatry;novel;Nucleic Acid Regulatory Sequences;Outcome;Parents;Partner in relationship;Pathway interactions;Patients;Pattern;Phenotype;pleiotropism;Population;Population Control;predictive tools;Predisposition;proband;public health relevance;Quantitative Evaluations;rare variant;Recording of previous events;Reporting;Risk;Sample Size;Schizophrenia;schizophrenia risk;Sensory;Severities;Smith Magenis syndrome;Source;statistical learning;Structure;System;Testing;therapeutic development;transmission process;Variant;whole genome;Work;Xenopus laevis;Zebrafish

PROJECT_TITLE: Genomic basis of phenotypic variability of complex disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-P(02)M]


PHR: PROJECT NARRATIVE Individuals with age-related neurodegenerative disorders often experience declining neuromuscular function that may be linked to accelerated biological aging, but clearer knowledge of these degenerative processes is needed to guide the development of new, effective therapies. The predoctoral (F99) phase of this award will use robust mouse models to thoroughly investigate neuromuscular dysfunction when faced with genetic disease, aging, and injury, as well as use of gene therapy as a treatment strategy. The K00 portion of this award will investigate cellular reprogramming of the motor unit as a way to improve longevity and resilience when faced with genetic disease, aging, and injury.

PI_NAMEs: RICH, KELLY  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Adult;Age;age acceleration;age related;age related neurodegeneration;aged;Aging;aging mechanism;Amyotrophic Lateral Sclerosis;Award;Biological;Biological Aging;career;career development;Cell Aging;cell injury;Cell Reprogramming;cell type;Chronology;Clinical;clinically relevant;combat;Communication;Data;design;Development;Development Plans;Disease;disease phenotype;effective therapy;Electrophysiology (science);Epigenetic Process;experience;Family member;Foundations;Functional disorder;functional loss;gene therapy;Genetic;Genetic Diseases;Genetic Predisposition to Disease;genetic variant;Genome;Goals;improved;in vivo;Individual;Injury;Institution;interest;Kinesin;Knowledge;Lead;Link;Longevity;Maintenance;Mediating;Mentorship;Motivation;Motor;Motor Neurons;mouse model;Mus;Muscle Fibers;mutant;Mutant Strains Mice;Mutation;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;neurogenetics;neuromuscular;neuromuscular function;neuronal transport;novel therapeutic intervention;Outcome;Pathologic;pathological aging;Pathology;Patients;Peripheral nerve injury;Phase;Phenotype;Physiological;Physiology;Population;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Process;Proteins;Publications;repaired;Research;Research Personnel;Research Project Grants;resilience;Risk Factors;Role;Science;Scientist;senescence;skills;Susceptibility Gene;Technical Expertise;tenure track;Testing;Therapeutic;therapy development;Tissues;transcription factor;transcriptional reprogramming;transcriptomics;transgene delivery;translational research program;treatment strategy;Viral Vector;Work

PROJECT_TITLE: Cellular reprogramming to promote longevity, resilience, and repair in motor unit degeneration


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: PROJECT NARRATIVE Proper control of RNA stability is key for correct gene expression, and requires fine-tuning at every level of a given mRNA life. The proposed research aims at characterizing how post-transcriptional modifications, in particular m6A, may control RNA turnover in the context of cellular stress using viral-induced RNA-decay as a model.

PI_NAMEs: MULLER, MANDY  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Affect;Cells;Cellular Stress;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;endonuclease;Environment;Equilibrium;Event;gene correction;Gene Expression;Human Herpesvirus 8;Life;Mammalian Cell;Messenger RNA;Modeling;Modification;Monitor;mRNA Stability;mRNA Transcript Degradation;Normal Cell;novel;nuclease;Pathogenicity;Pathway interactions;Post-Transcriptional Regulation;Post-Transcriptional RNA Processing;posttranscriptional;Predisposition;Process;Reader;Regulation;Research;Resistance;response;RNA;RNA Decay;RNA Degradation;RNA immunoprecipitation sequencing;RNA Stability;Site;Source;Stimulus;Stress;System;Testing;Time;tool;transcriptome;transcriptome sequencing;Viral;Virus

PROJECT_TITLE: RNA Modifications and Turnover during Viral-induced Decay

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]