NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Cardiovascular;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Heart Disease;Infectious Diseases;Patient Safety;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE The COVID-19 pandemic has affected millions of vulnerable individuals, many of whom are likely to have sustained some degree of end-organ cardiac disease or dysfunction. We propose to use high-resolution cardiac imaging and immune-inflammatory profiling methods, conducted serially over time, to improve our understanding of COVID-19 cardiac disease and its potential for resolution versus persistence in affected persons.

PI_NAMEs: CHENG, SUSAN  (contact);LI, DEBIAO

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: 2019-nCoV;Adverse effects;adverse outcome;Affect;Age;Artificial Intelligence;Cardiac;cardiac magnetic resonance imaging;Cardiomyopathies;cardiovascular risk factor;Cardiovascular system;Caring;Cicatrix;Clinical;co-infection;Communities;comorbidity;coronary fibrosis;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 patient;COVID-19 sequelae;cytokine release syndrome;Data;Development;Diabetes Mellitus;Disease;Eicosanoids;Enrollment;Environment;Ethnic Origin;experience;fluorodeoxyglucose positron emission tomography;Functional disorder;Grant;Heart;Heart Diseases;heart imaging;Heterogeneity;High Prevalence;hospital readmission;Hospitalization;Hospitals;imaging modality;Immune;improved;indexing;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;interest;Knowledge;Lipids;Long COVID;lung injury;Mass Spectrum Analysis;Measures;Mediating;Mediator;Medical;Methods;Molecular;Multimodal Imaging;Myocardial;Myocardial dysfunction;Myocarditis;Natural History;novel;Obesity;Organ;Outcome;pandemic disease;Patient Self-Report;Patients;Perfusion;persistent symptom;Persons;Phenotype;Positron-Emission Tomography;post SARS-CoV-2 infection;Post-Acute Sequelae of SARS-CoV-2 Infection;Predisposition;primary outcome;prospective;Prospective Studies;Race;Recovery;Recurrence;Reporting;Resolution;Risk;Risk Factors;Sampling;Sampling Studies;SARS-CoV-2 infection;SARS-CoV-2 negative;secondary analysis;severe COVID-19;Severities;Severity of illness;sex;Socioeconomic Status;Source;Specific qualifier value;Stress;stressor;Structure;Symptoms;Time;trait;Troponin;Ultrasonography;ultrasound;United States;Vulnerable Populations;Work

PROJECT_TITLE: Cardiac microstructure and the immune-inflammatory response to SARS-CoV-2

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Digestive Diseases;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SURGERY

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Necrotizing enterocolitis (NEC) is the leading cause of death from gastrointestinal disease in premature infants, and for which there exists no effective cure. The current proposal has identified four major questions in the field of NEC which we now seek to answer, through a novel focus on identifying what causes NEC, how we can prevent NEC, how we can predict NEC, and how we can reduce the impact of NEC on causing long term complications on the brain, the gut and the lung.

PI_NAMEs: HACKAM, DAVID J (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Address;Affect;Bacteria;Blood flow;Brain;Cause of Death;Cessation of life;Color;Communities;Development;Diet;Disease;experience;feeding;Gastrointestinal Diseases;Genetic;Goals;gut inflammation;Hour;Human;Human Milk;human tissue;Image;Inflammation;Inflammatory;Inflammatory Response;intestinal epithelium;Intestines;Knowledge;Laparotomy;Legal patent;Link;Lipopolysaccharides;Lung;machine learning prediction algorithm;Metabolic;Modeling;Molecular;Mus;Necrosis;Necrotizing Enterocolitis;novel;novel therapeutics;organ injury;Organoids;Pathogenesis;Pathway interactions;Patients;premature;Premature Infant;prevent;receptor;Research;Role;Sepsis;Signal Transduction;Textbooks;Thinking;Tissues;TLR4 gene;Writing

PROJECT_TITLE: Molecular and metabolic signaling in necrotizing enterocolitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ORG_CITY: PHILADELPHIA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative Many human diseases result from malfunctioning of actin cytoskeletal components, including Arp2/3 complex, a 7-subunit complex involved in actin filament nucleation and branching. This grant addresses important gaps of knowledge of the mechanisms of Arp2/3 complex activation, inhibition, branch stabilization, and branch destabilization, and has both fundamental importance and the potential to accelerate the development of targeted therapies to treat human diseases such as cancer.

PI_NAMEs: DOMINGUEZ, ROBERTO  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Acceleration;Acidic Region;Actins;Address;Area;ATP Hydrolysis;beta Actin;Binding;Biochemical;Biological Assay;C-terminal;Calorimetry;cell motility;Cells;Coiled-Coil Domain;Complex;coronin protein;crosslink;Cryoelectron Microscopy;Cytoskeleton;Daughter;Development;Dissociation;dynamic system;EMS1 gene;Environment;Eukaryota;experimental study;F-Actin;Family;Filament;Glia Maturation Factor;Grant;Human;human disease;inhibitor;innovation;interest;Knowledge;Laboratories;Link;Malignant Neoplasms;Measures;member;Methods;Microfilaments;Microfluidics;Modeling;Molecular;monomer;Mothers;Mutagenesis;N-terminal;novel;Nucleotides;Organelles;Play;polymerization;Polymers;Process;protein expression;Protein Family;Protein Isoforms;Proteins;Publishing;Pyrenes;Recombinants;Reporting;Research Support;Resolution;Role;Site-Directed Mutagenesis;Structure;System;targeted treatment;Testing;Titrations;Total Internal Reflection Fluorescent;Work;Yeasts

PROJECT_TITLE: Structural-Functional Basis of Actin Cytoskeleton Dynamics

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Data Science;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative This project seeks to develop federated learning approaches for distributed research networks where data are heterogeneously fragmented and individual-participant data cannot be pooled. The proposed methods enable health policy researchers to maximally harness the power of big data by integrating Medicaid modeling results from eleven states. The focus dedicated to the handling of data heterogeneity will enhance statistical power and generalizability of findings and improve our understanding of treatment for opioid use disorder.

PI_NAMEs: TANG, LU  (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Address;Big Data;Buprenorphine;buprenorphine treatment;Cells;Characteristics;Clinical;Collection;Complex;Computer software;Confidence Intervals;Data;data integration;Data Sources;Decision Making;Dedications;demographics;distributed data;diverse data;Dose;effectiveness clinical trial;empowerment;Ensure;Environment;federated learning;Formulation;Goals;Health;Health Policy;Heterogeneity;heterogenous data;Hospitals;improved;improved outcome;Individual;individualized medicine;information model;innovation;insight;Learning;learning strategy;Left;Low income;Machine Learning;Medicaid;medication for opioid use disorder;Meta-Analysis;Methodology;Methods;Modeling;mortality;multiple data sources;novel strategies;Opioid;opioid overdose;opioid use disorder;Outcome;Overdose;overdose death;overdose prevention;Overdose reduction;Participant;Pennsylvania;personalized approach;Pharmaceutical Preparations;Policies;Population;Population Heterogeneity;Population Research;Precision Health;precision medicine;programs;randomized, clinical trials;Recommendation;repository;Research;Research Personnel;Safety;Sampling;Scheme;Site;social health determinants;Source;Subgroup;success;System;Testing;Translational Research;treatment choice;treatment effect;Uncertainty;US State;user friendly software;user-friendly;Variant;Vulnerable Populations

PROJECT_TITLE: Federated learning methods for heterogeneous and distributed Medicaid data

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Vascular dysfunction contributes to pathogenesis of stroke, myocardial infarction, hypertension and heart failure, which cause one-third of deaths worldwide; however, there have been no mechanistically novel treatments for vascular dysfunction in the past 30 years. Vascular dysfunction and human hypertension are associated with mitochondrial dysfunction and oxidative stress which produce highly reactive cytotoxic isolevuglandins and inactivate a key of mitochondrial regulator, Sirtuin 3. In the proposed studies, we will define the novel role of mitochondrial isolevuglandins in Sirtuin 3 inactivation and vascular dysfunction, and we will establish the therapeutic potential of our new mitochondria-targeted blockers of isolevuglandins in vascular tissue isolated from hypertensive patients which can make a major impact on the development of new treatments.

PI_NAMEs: DIKALOV, SERGEY  (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Acetylation;antioxidant enzyme;Aorta;Arteries;arteriole;Attenuated;Blood Vessels;Cardiovascular Diseases;Cell Aging;Cell Physiology;Cessation of life;Clinical Treatment;cytotoxic;Data;Deacetylase;Deacetylation;Development;Drug Targeting;endothelial dysfunction;Endothelium;Essential Hypertension;fatty acid metabolism;Female;Functional disorder;Heart failure;Human;human subject;Hypertension;hypertensive;Hypertrophy;Impairment;improved;Inflammation;innovation;insight;Interdisciplinary Study;Lipid Peroxidation;Lysine;male;Mediating;Metabolic dysfunction;mimetics;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Molecular;mouse model;Mus;muscle hypertrophy;Myocardial Infarction;new therapeutic target;novel;novel therapeutics;Organ;Oxidative Stress;Pathogenesis;Pathway interactions;Patients;peroxidation;Play;Polyunsaturated Fatty Acids;Positioning Attribute;prevent;Relaxation;Research;Role;Sirtuins;Smooth Muscle;Smooth Muscle Myocytes;SOD2 gene;Stroke;Superoxide Dismutase;Testing;Therapeutic;therapeutic evaluation;Tissues;Transgenic Mice;Vascular Diseases;vascular inflammation;Vasodilation;Viscosity;Work

PROJECT_TITLE: Sirtuin 3 Inactivation and SOD2 Acetylation in Vascular Dysfunction and Hypertension

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_STATE: CA

PHR: PROJECT NARRATIVE  To predict treat and/or cure Type 2 diabetes, we have to understand the mechanisms which underlie the changes which cause the disease. From the experiments supported by this grant, we will explain a particular potential cause of the disease related to the ability of sugar itself to be stored in the liver and other organs.

PI_NAMEs: ADER, MARILYN  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: absorption;Accounting;Adipose tissue;Antisense Oligonucleotides;basal insulin;Beta Cell;Biopsy;Blood;canine model;Canis familiaris;Cell Physiology;Closure by clamp;Compensation;Computer Models;design;Diabetes Mellitus;diet-induced obesity;Disease;Down-Regulation;Effectiveness;effectiveness measure;enzyme activity;Enzymes;Exercise;exercise regimen;Experimental Models;experimental study;feeding;FGF1 gene;Functional disorder;Genes;Genetic;genetic regulatory protein;Glucokinase;glucokinase regulatory protein;Glucose;Glucose Clamp;glucose production;glucose tolerance;glucose uptake;Grant;Hepatic;Hyperglycemia;Hyperinsulinism;impaired glucose tolerance;improved;in vivo;indexing;Injections;innovation;inorganic phosphate;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;interest;intravenous administration;intravenous glucose tolerance test;Laboratories;Liver;liver biopsy;Liver Glycogen;Measurement;Measures;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Methodology;Methods;Modeling;Muscle;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Oral Administration;Organ;Pathogenesis;Pathway interactions;phosphoproteomics;Phosphorylation;Physiological;Plasma;Play;Prediabetes syndrome;prevent;Prevention;Production;Proteins;Protocols documentation;Research Design;response;Role;Series;Streptozocin;sugar;Testing;Time;Tissues;Tracer;Validation;validation studies

PROJECT_TITLE: Quantitation of Factors Regulating Glucose Tolerance

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Neurosciences

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE This proposal aims to develop a new 3D-scanning two-photon fiberscopy imaging technology, which will overcome the challenges in currently available brain imaging technologies and allow for assessment of functional and dynamic connectivity of neural networks from different brain regions with high-resolution in freely-moving animal models (e.g., rodents). Successful development of the proposed technology could potentially accelerate the process of uncovering general principles of neural circuits in a working brain.

PI_NAMEs: LI, XINGDE  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: 3-Dimensional;Acceleration;Animal Model;Area;Behavior;Biomedical Engineering;Brain;Brain imaging;Brain region;calcium indicator;cantilever;cell type;Cognitive;Collaborations;Columbidae;Communities;Compensation;Decision Making;design;Development;Diagnosis;Fiber Optics;Frequencies;Head;high resolution imaging;histological image;Image;Imaging Device;imaging platform;Imaging technology;improved;in vivo;in vivo imaging;in vivo Model;innovation;interest;Intervention;lens;Light;light weight;liquid crystal;Locomotion;microscopic imaging;Microscopy;midbrain central gray substance;Monitor;Motor;Motor Cortex;mouse model;multiphoton microscopy;Mus;neural;neural circuit;Neural Interconnection;neural network;neuroimaging;neuronal circuitry;Neurons;Neurosciences;novel;optical imaging;Optics;Organ;Performance;performance tests;phantom model;Play;Population;preference;Process;Productivity;programs;Publications;Recording of previous events;Refractive Indices;Research;Resolution;restraint;Rodent;Role;Rotation;Route;Running;Scanning;Sensory;Signal Transduction;Slice;Slide;social;Social Behavior;spatiotemporal;synergism;System;Technology;Testing;Thick;three photon microscopy;Time;timeline;Tissues;tool;Torque;translational applications;two-photon;Universities;virtual;voltage;Walking;Washington

PROJECT_TITLE: 3D Scanning Two-photon Fiberscope Technology for Simultaneous Multi-region Multi-cell-type Imaging in Freely-moving Rodents

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Human Genome;Kidney Disease;Prevention;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Chronic kidney disease (CKD) affects 10-15% of the population world-wide and is associated with high mortality. We propose to develop and validate polygenic risk scores for CKD and its subtypes to aid in the early detection of kidney disease, before its onset, providing orthogonal risk information to the traditional disease risk factors. This proposal will lay groundwork for potential use of polygenic predictors of kidney disease in a clinical setting.

PI_NAMEs: KHAN, ATLAS  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Affect;Age;American;Atrial Fibrillation;Award;biobank;biomedical informatics;Biomedical Research;Body mass index;career;career development;causal variant;Characteristics;Chronic Disease;Chronic Kidney Failure;Clinical;clinical application;cohort;Colon Carcinoma;comorbidity;Computerized Medical Record;Coronary Arteriosclerosis;Data;Data Set;density;Development;Development Plans;Dimensions;direct application;Disease;disease diagnosis;Disease Progression;disorder risk;Early Diagnosis;Early treatment;Electronic Health Record;Electronics;End stage renal failure;Enrollment;ethnic diversity;European;Evolution;Familiarity;Focal and Segmental Glomerulosclerosis;Foundations;Funding;Future;Genetic;genetic risk factor;Genetic study;genetic variant;genome wide association study;genome-wide;Genomic medicine;Genomics;Genotype;Goals;Healthcare Systems;high risk;IGA Glomerulonephritis;improved;Individual;Inflammatory Bowel Diseases;K-Series Research Career Programs;Kidney Diseases;Knowledge;Life;lifetime risk;Link;Malignant Breast Neoplasm;Membranous Glomerulonephritis;Mentors;Methods;Modeling;Morbid Obesity;mortality;Nephrology;novel;Obesity;Outcome;Participant;Pathogenesis;patient oriented;Patients;phenome;Phenotype;phenotypic data;polygenic risk score;Population;Prevention;Prospective cohort;Public Health;rare variant;recruit;Renal function;Research;research and development;Research Personnel;Research Project Grants;Resources;Risk;Risk Factors;Risk Marker;Sampling;SNP array;Testing;Time;Training;United Kingdom;Variant

PROJECT_TITLE: Predictive utility of polygenic risk scores for chronic kidney disease.

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Estrogen;Infectious Diseases;Mental Health;Neurosciences;Urologic Diseases;Women's Health Research

PHR: PROJECT NARRATIVE In this project, we propose to understand the role of 17β-estradiol in ameliorating urinary tract infection-induced delirium. Briefly, we will use our novel model of urinary tract infection-induced delirium, oophorectomized mice, state-of-the-art behavioral testing, and genetically modified mice to determine whether 17β-estradiol ameliorates the structural and functional phenotypes of delirium via the G protein-coupled estrogen receptor 1. Given the lack of evidence-based pharmacological treatments for delirium, the findings from this research could have widespread clinical implications, including providing novel pre-clinical justification for clinical trials using a short-term application of an existing drug, 17β-estradiol, to ameliorate UTI-induced delirium and quality of life for millions of older women.

PI_NAMEs: LAHIRI, SHOURI  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acceleration;Acute;Affect;Age;Anatomy;Animals;antagonist;Anti-Inflammatory Agents;Apoptotic;aptamer;Attention;Behavior;behavior test;behavioral impairment;Blood;Brain;Brain Injuries;CASP3 gene;Cell membrane;Clinical;Clinical Trials;Data;Delirium;Elderly;ESR1 gene;Estradiol;Estrogens;evidence base;executive function;Female;frontal lobe;Gene Modified;GPER gene;Hippocampus;Hormones;Hospitalization;Human;human old age (65+);Immune;Immunohistochemistry;Impaired cognition;Impairment;improved;Infection Control;insight;Length of Stay;Mediating;Mediator;men;Modeling;Modification;mortality;mouse model;Mus;Nerve Degeneration;Neuronal Dysfunction;neuroprotection;non-genomic;novel;old mice;older women;Ovariectomy;Pathogenesis;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phenotype;Postmenopause;pre-clinical;Predisposition;Proteomics;Quality of life;Research;response;Risk;Risk Factors;Role;Short-Term Memory;Signal Transduction;Specimen;Testing;transcriptome sequencing;Urinary Tract Finding;Urinary tract infection;Western Blotting

PROJECT_TITLE: The Role of 17β-Estradiol in Delirium

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Vector-Borne Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Broadly acting antivirals are desperately needed to fight emerging viruses and their development depends on understanding the mechanisms of broad-spectrum antiviral proteins such as ZAP. Our proposed studies aim to characterize both cellular and viral determinants critical for TRIM25-mediated ZAP translational inhibition using the alphavirus system. This research will elucidate key ubiquitination substrates required for ZAP activity and viral escape strategies, which will provide actionable insights into identification of therapeutic targets against multiple viruses.

PI_NAMEs: LI, MELODY  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: 2019-nCoV;Affect;Alpha Virus;antagonist;Anti-viral Agents;Anti-viral Therapy;antiviral drug development;Attenuated;Attenuated Vaccines;Cell Physiology;Cellular biology;cellular targeting;Chikungunya virus;Chimera organism;CpG dinucleotide;design;Development;DNA Viruses;emerging virus;Epidemic;fighting;Financial Hardship;Flavivirus;Gene Chips;Genes;Goals;GTPase-Activating Proteins;Health;HIV-1;Immunology;Individual;Innate Immune Response;innovation;insight;Integration Host Factors;Interferon Type I;Interferons;IRF3 gene;Knowledge;Link;Manuscripts;Maps;Mediating;Molecular;Nervous System Disorder;novel;O'nyong-nyong virus;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Predisposition;Preparation;Process;Production;Protein Binding Domain;Protein Inhibition;Proteins;ras GTPase-Activating Proteins;recruit;Research;Resistance;Resistance development;resistance mechanism;RNA;RNA Degradation;RNA Splicing;RNA Viruses;Role;SH3 Domains;Shapes;Structure;success;System;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Time;Transcript;Translational Repression;Translations;TRIM25 gene;ubiquitin-protein ligase;Ubiquitination;vaccine development;Variant;Viral;Viral Pathogenesis;Viral Physiology;Viral Proteins;viral resistance;viral RNA;virology;Virulence;Virulent;Virus;Virus Diseases;Virus Replication;Work;Zinc Fingers

PROJECT_TITLE: Functional analysis of host and viral determinants for ZAP inhibition

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative The proposed research is highly relevant to public health as the elucidation of the regulation and functions of PTEN is expected to uncover key pathogenic mechanisms for tumorigenesis, and will therefore yield important opportunities to advance therapeutic options and improve outcomes for cancer patients. Thus the proposed research is relevant to the NIH’s mission to develop fundamental knowledge that will help develop the effective strategy for precision cancer therapy.

PI_NAMEs: SONG, MIN SUP  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Adrenal Glands;Automobile Driving;Award;Biochemical;cancer cell;Cancer Patient;Cell Cycle;Cell Cycle Progression;Cell Nucleus;Cell Proliferation;chromatin remodeling;Chromatin Remodeling Factor;Colorectal;Cytoplasm;Data;Deubiquitination;Development;DNA Repair;DNA Sequence Alteration;Ensure;epigenome;Equilibrium;Essential Genes;Exclusion;Feedback;FRAP1 gene;genome integrity;Genome Stability;Genomic Instability;Genomics;Glutamates;Goals;Human;Impairment;improved outcome;In Vitro;in vivo;Induction of Apoptosis;Inherited;insight;Investigation;knock-down;Knock-in Mouse;Knowledge;Lead;Link;loss of function;Lysine;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Metabolic;Mission;Modeling;Modification;Molecular;mouse model;multiple omics;mutant;Mutant Strains Mice;Mutate;Mutation;novel;novel therapeutics;Nuclear;Nuclear Import;Organoids;Pathogenicity;Pathologic;Pathway interactions;phosphoinositide-3,4,5-triphosphate;Phosphoric Monoester Hydrolases;Physiological;PIK3CG gene;Play;Post-Translational Protein Processing;Precision cancer therapy;Precision therapeutics;prevent;Prostatic hypertrophy;Protein Dephosphorylation;Proteome;Proto-Oncogene Proteins c-akt;PTEN gene;PTEN Hamartoma Tumor Syndrome;Public Health;Regulation;Research;Resistance;Role;Signal Transduction;Succinates;Syndrome;Testing;Therapeutic;transcriptome;tumor;tumor growth;Tumor Suppression;Tumor Suppressor Genes;tumorigenesis;Ubiquitination;United States National Institutes of Health;Work;Zinc Fingers

PROJECT_TITLE: The role of PTEN feedback mechanism in cancer

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: Abnormal sleep-wake cycles, manic depression, cancer, and seasonal affective disorder are all linked to circadian clock dysfunction. Increasing evidence suggests that they are either caused by genetic factors such as clock gene variants or desynchrony between the human body and its environment due to societal factors such as jetlag, shiftwork, and light pollution. The goal of the proposed studies is to define a fundamental feature of the clock mechanism that controls the phase, period and amplitude of circadian rhythms, which could ultimately serve as a molecular foundation to aid in the diagnosis and treatment of clock disorders.

PI_NAMEs: HARDIN, PAUL E;MERLIN, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Acceleration;Aloral;Animal Behavior;Animals;Arginine;ARNTL gene;Binding;Biological Models;Biological Process;Brain;Butterflies;casein kinase I;Cells;chaperonin;circadian;circadian pacemaker;Circadian Rhythms;Clock protein;Complex;cryptochrome;Development;Diabetes Mellitus;Diagnosis;Diagnostic;Disease;DNA;DNA Binding;Drosophila genus;Drosophila melanogaster;E-Box Elements;effective therapy;Environment;Event;Excision;Exons;experimental study;Family member;Feedback;Foundations;Functional disorder;Funding;gene repression;Genes;Genetic;genetic corepressor;Genetic Transcription;genetic variant;Goals;Health;Heat shock proteins;Heat-Shock Proteins 70;histone methylation;histone methyltransferase;Human;Human body;insight;Jet Lag Syndrome;Knowledge;Light;Link;Lysine;Malignant Neoplasms;Mammals;Manic;Mediating;member;Mental Depression;Metabolism;Methylation;Modeling;Molecular;Molecular Conformation;Neurons;novel;novel therapeutics;Pathway interactions;Periodicity;Peripheral;Phase;Phosphorylation;Physiology;Pollution;Protein Family;protein function;Protein-Arginine N-Methyltransferase;Proteins;Repression;Seasonal Affective Disorder;shift work;sleep abnormalities;Sleep Wake Cycle;Societal Factors;Substrate Specificity;Testing;Time;Tissues;Transcription Initiation;Transcriptional Activation;Transcriptional Regulation;Work

PROJECT_TITLE: Mechanisms of Circadian Repression

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE During an infection, animals display a stereotyped set of symptoms aimed at increasing survival, such as elevation in core temperature aimed to fight pathogens (fever), decreased activity and appetite. Advanced molecular and genetic technologies allow for the dissection of dedicated neural pathways involved in specific physiological and behavioral responses, providing novel targets for diagnosis and therapeutic development. This proposal aims to leverage cutting edge molecular and genetics approaches to uncover the specific neuronal populations and neural circuits underlying the generation of fever and associated sickness symptoms.

PI_NAMEs: DULAC, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Ablation;acute infection;adaptive immune response;Adipose tissue;Affect;Animals;Area;associated symptom;Atlases;Attenuated;attenuation;Awareness;Behavior;Behavioral;behavioral response;Body Temperature;Brain;cell type;Cells;Collaborations;cytokine;Data;Dedications;Desire for food;Diagnosis;Dinoprostone;Dissection;Dorsal;Exhibits;experimental study;Fever;fighting;Fluorescent in Situ Hybridization;Future;Gene Expression;Generations;Genes;Genetic;genetic approach;genetic information;genetic technology;Goals;Human;Hypothalamic structure;imaging modality;Immediate-Early Genes;Immune;Immune response;Immune signaling;Immunologic Factors;In Situ;Induced Neurons;inducible Cre;Infection;Inflammatory;inhibitor;Injections;Innate Immune Response;insight;Lethargies;Libraries;Lipopolysaccharides;Medial;Mediating;Methods;Middle Hypothalamus;Modeling;Molecular;Mus;Nervous System;neural circuit;Neural Pathways;Neuroglia;neuronal circuitry;Neurons;novel;novel strategies;novel therapeutic intervention;Optics;paracrine;paraventricular nucleus;pathogen;Patients;Physiologic Thermoregulation;Physiological;Physiology;Population;Preoptic Areas;promoter;Prostaglandin Receptor;Prostaglandins;Proteins;response;Role;single-cell RNA sequencing;Stereotyping;Symptoms;Synapses;Temperature;Testing;therapeutic development;Thermogenesis;tool;treatment strategy;Universities;Viral

PROJECT_TITLE: Molecular and Genetic Dissection of Brain Circuits Controlling Fever

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: This project investigates the basic mechanisms by which the dysregulated mitochondrial calcium signaling promotes pancreatic cancer metastasis, which accounts for more than 90% of pancreatic cancer-related death. The anticipated results from this proposal will significantly advance our understanding of pancreatic cancer metastasis, and potentially provide novel strategy for preventing metastatic progression in pancreatic cancer.

PI_NAMEs: SINGH, PANKAJ KUMAR;YANG, SHENGYU  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: addiction;Antioxidants;antiporter;Biguanides;Calcium Signaling;calcium uniporter;Cancer Control;cancer type;Cell Death;Cell membrane;cell motility;Cells;Cessation of life;chemotherapy;Cystine;Data;Data Set;Depressed mood;deprivation;Disease;druggable target;Genes;Genetically Engineered Mouse;Glutamates;Glutathione;Goals;inhibitor;Inner mitochondrial membrane;insight;Invaded;Iron;Lipid Peroxidation;Lipids;Malignant neoplasm of pancreas;Mediating;Membrane Proteins;Metabolic stress;Metastatic/Recurrent;Mitochondria;Modeling;Molecular;mouse model;Mus;Neoplasm Metastasis;novel;novel strategies;Organelles;Outer Mitochondrial Membrane;overexpression;Oxidative Stress;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathologic;Patients;peroxidation;prevent;programs;Pump;recruit;Regulation;Research;Resistance;response;Response Elements;Role;Signal Transduction;success;System;The Cancer Genome Atlas;Therapeutic;transcriptome sequencing;transcriptomics;tumor progression;uptake;Xenograft Model

PROJECT_TITLE: Mitochondrial calcium signaling in pancreatic cancer metastasis and progression

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Plant-based diets are healthy dietary patterns that are consistently associated with a lower risk of cardiovascular disease (CVD) and CVD risk factors. The proposed research seeks to uncover the mechanisms underlying plant-based diets and CVD by comprehensively characterizing the proteome and methylome, and integrating multiple omics data from 3 large prospective cohorts. The proposed research will yield novel evidence on protein markers and epigenetic markers of plant-based diets, and pathways linking plant-based diets to CVD, thus providing a basis to formulate CVD prevention and treatment strategies.

PI_NAMEs: KIM, HYUNJU  (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: Adherence;adjudication;Affect;African American;American;Animals;aptamer;Area;Atherosclerosis Risk in Communities;Biological;Biological Process;Biology;Blood Pressure;Body mass index;cardiometabolic risk;cardioprotection;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular system;career;cohort;collaborative environment;Communities;Data;Data Discovery;Data Set;Diet;dietary guidelines;Dietary intake;Dietary Practices;Dimensions;Disease Outcome;DNA Methylation;Doctor of Philosophy;early detection biomarkers;Early identification;Eating;Edible Plants;Elasticity;Ensure;Epidemiology;epigenetic marker;Epigenetic Process;Etiology;European;Event;experience;Five-Year Plans;follow-up;Food;Framingham Heart Study;Future;Gene Expression;Genes;Goals;good diet;hands on research;Homeostasis;indexing;Inflammation;Inflammatory;Knowledge;Link;Machine Learning;Mentored Research Scientist Development Award;Mentors;Mentorship;Metabolic;Metabolism;metabolome;metabolomics;Methylation;methylation pattern;methylome;Methyltransferase;middle age;Multi-Ethnic Study of Atherosclerosis;multidisciplinary;Multiomic Data;multiple omics;novel;nutrition;Nutritional;nutritional epidemiology;Nutritional Study;Pathogenesis;Pathway interactions;Pattern;Phenotype;Plants;prevent;Prevention strategy;Production;Productivity;programs;prospective;Prospective cohort;Prospective Studies;protein biomarkers;Proteins;Proteome;Proteomics;Public Health Schools;Publishing;Recommendation;Research;Research Personnel;Research Proposals;Research Training;Risk Factors;Risk Reduction;Sample Size;skills;Statistical Models;Techniques;Technology;therapeutic target;Training;treatment strategy;Validation;Vascular Diseases;Vegan Diet

PROJECT_TITLE: Proteomic and epigenetic alterations associated with plant-based diets and CVD

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences

PHR: Project Narrative / Relevance This proposal's primary goal is to explore and demonstrate that selective regional vulnerability in Alzheimer’s disease and incremental hierarchical spreading of hyperphosphorylated Tau and deposition of NFT are associated and interconnected with changes in expression of small non- coding RNAs and chromatin architecture. We will achieve the goal by interrogating 3 distinct anatomical brain regions at different Braak stages using molecular genetics and cell biology tools and animal models.

PI_NAMEs: KOLDAMOVA, RADOSVETA  (contact);LEFTEROV, ILIYA

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: abeta accumulation;Address;Admission activity;Affect;age group;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer's disease patient;Amyloid deposition;amyloid precursor protein processing;Anatomy;Animal Model;Architecture;Autopsy;Binding;Biochemical;Biochemical Process;Brain;Brain region;Cell Nucleus;Cell Physiology;Cellular biology;Chromatin;chromatin remodeling;Chromatin Structure;Co-Immunoprecipitations;comparison control;Complex;Cytoplasm;Data;Dementia;Deposition;Development;Disease;Early Diagnosis;Epigenetic Process;epigenomic profiling;epigenomics;Event;extracellular;extracellular vesicles;Family;Functional impairment;Gene Expression;Genetic;Genetic Transcription;genome-wide;Genomics;Genotype;Goals;Human;human subject;hyperphosphorylated tau;imprint;Inferior;Late Onset Alzheimer Disease;Link;Lobule;MAPT gene;Methylation;Modification;Molecular;Molecular Genetics;mouse model;mRNA Precursor;Mus;neurofibrillary tangle formation;Neurofibrillary Tangles;neuron loss;Neurons;non-demented;Nuclear;Nucleic Acid Regulatory Sequences;Parietal;Pathogenesis;Pathologic;Pathology;Phosphorylation;Physiological;Plasma;Play;Proteins;Research;Research Personnel;RNA;RNA Binding;RNA Processing;RNA Splicing;Role;Sampling;Senile Plaques;Site;Small Nuclear RNA;Small Nucleolar RNA;Small RNA;SNRPN;tau aggregation;tau Proteins;tool;Transcriptional Regulation;transcriptomic profiling;Translating;Untranslated RNA

PROJECT_TITLE: The interplay between Tau and ncRNAs – genomic and epigenomic clues to early AD pathogenesis


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The proposed research seeks to develop an engineered surface that enables mucociliary transport (MCT) function. This project will benefit patients with implanted and indwelling medical devices to prevent mucus plugging, reduce bacterial infection, and reduce social and economic care burdens.

PI_NAMEs: XIE, YULIANG  (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: 3D Print;Acoustics;Adhesions;Agar;Aluminum Oxide;Animal Model;animal tissue;Antibiotics;Bacteria;Bacterial Infections;Banana;Biological;Biology;Biomedical Engineering;Breathing;care burden;Chemistry;chronic infection;Cilia;Clinical;Communities;design;Development;Devices;Dimensions;driving force;Economics;Effectiveness;endotracheal;Engineering;Environment;Epithelium;ethylene glycol;fabrication;Family suidae;female reproductive tract;Fertilization;Foundations;Friction;Gel;Gold;Health;Human;Hydrogels;hydrophilicity;Implant;In Vitro;in vivo;in vivo evaluation;Infection;infection burden;Inhalation;innovation;Iowa;Lateral;Lung;mechanical force;Medical Device;Medicine;Methods;Microfluidics;Modification;Motion;Movement;Mucociliary Clearance;Mucolytics;Mucous body substance;mucus clearance;Ocular Prosthesis;Organ;Outcome;pathogen;Patients;Penetration;Pharmaceutical Preparations;Physiology;poly(ethylene glycol)diacrylate;polydimethylsiloxane;Polymers;Polysaccharides;porcine model;prevent;Process;programs;prototype;Reporting;reproductive tract;Research;Research Personnel;Respiratory System;Risk;Side;side effect;slug;social;sperm cell;stem;Sterility;Structure;success;Suction;Surface;surface coating;Technology;Testing;Tissues;Trachea;Tracheostomy Tube;Transportation;Tube;ultrasound;Universities;Validation;vibration;Voice Prostheses

PROJECT_TITLE: An Engineered Surface of Mucociliary Transport for Medical Devices

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Opioids;Pain Research;Peripheral Neuropathy

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Cold hypersensitivity and cold pain affects a number of diverse groups of patients and goes largely untreated. We do not have clear understanding of the mechanisms involved in the modulation of cold pain. The goal of this proposal is to investigate the role of the peripheral kappa opioid receptor system in cold hypersensitivity and cold pain.

PI_NAMEs: AL-HASANI, REAM  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Affect;Afferent Neurons;allodynia;Animals;ANK1 gene;anti-epileptic agents;antinociception;Automobile Driving;Bathing;Behavioral;Binding;Biological Assay;Calcium;Calcium Signaling;Cells;Central Nervous System;chemotherapy;Chemotherapy-induced peripheral neuropathy;Chronic;chronic constriction injury;Chronic pain syndrome;Complex;Data;Detection;Diagnosis;effective therapy;Electrophysiology (science);Esthesia;Etiology;Future;Goals;GTP-Binding Proteins;Human;human tissue;Hypersensitivity;Image;In Situ Hybridization;in vivo;kappa opioid receptors;Knock-out;Knockout Mice;Measures;Mechanics;Mediating;Modeling;Multiple Sclerosis;Mus;negative affect;Neurons;Neuropathy;new therapeutic target;Non-Steroidal Anti-Inflammatory Agents;Nucleus Accumbens;Opioid;Opioid agonist;Opioid Antagonist;Organ Donor;Pain;pain patient;painful neuropathy;Pathologic;Patients;Peripheral;Peripheral Nervous System;Pertussis Toxin;Pharmaceutical Preparations;pharmacologic;Pharmacology;Platinum;Play;preservation;receptor;Receptor Activation;receptor expression;recruit;Reporting;Research;Rodent Model;Role;side effect;Signal Transduction;Spinal Ganglia;Stimulus;System;Tail;Temperature;Testing;therapeutic target;Tissues;Transgenic Organisms;TRP channel;viral rescue;Wild Type Mouse;Withdrawal

PROJECT_TITLE: Peripheral Mechanisms of Kappa Opioid Receptor-Mediated Cold Hypersensitivity

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Patient Safety;Precision Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Narrative Anti-arrhythmia therapy remains a process of trial-and-error, because clinicians cannot predict in advance how a patient will respond to a specific drug. We have developed methods to predict the response of patients with rare genetic variations in the cardiac sodium channel. With this project, we will expand this approach to common variations and conditions to predict whether certain patients with ventricular arrhythmia will be well-treated with mexiletine therapy, which has fewer side effects than more commonly prescribed drugs.

PI_NAMEs: SILVA, JONATHAN R (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Adrenergic Agents;Affect;Amiodarone;Anti-Arrhythmia Agents;Arrhythmia;biophysical properties;Biophysics;Blinded;Cardiac;Cardiac Myocytes;Cardiomyopathies;Clinical;Clinical Research;Clinical Trials;cohort;Computer Models;cost;Data;Diagnosis;Discipline;Disease;Dose;drug efficacy;Drug Interactions;Drug Modelings;Drug Prescriptions;Drug Regulations;experimental study;Genetic;genetic information;genetic variant;Genetic Variation;genomic data;Genotype;Guidelines;heart rate variability;heart rhythm;Implantable Defibrillators;implantable device;improved;improved outcome;induced pluripotent stem cell;insight;Macromolecular Complexes;Maps;Mass Spectrum Analysis;Measures;Membrane;Methods;Mexiletine;Modeling;Molecular;Molecular Conformation;Movement;Mutation;novel;Outcome;Outcome Measure;outcome prediction;Pain;patient derived induced pluripotent stem cells;patient registry;patient response;patient subsets;Patients;Peripheral Blood Mononuclear Cell;personalized medicine;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Phosphorylation;Phosphorylation Site;Physicians;Precision therapeutics;predicting response;predictive modeling;prevent;Process;prospective;Protocols documentation;rare variant;rational design;Regimen;Registries;Regulation;Reporting;response;Shock;side effect;simulation;Sodium Channel;stem cell differentiation;stem cell model;Structure;Syndrome;Testing;therapy outcome;Toxic effect;translational approach;treatment strategy;Variant;Ventricular;Ventricular Arrhythmia;Ventricular Fibrillation;Ventricular Tachycardia;voltage;wearable device

PROJECT_TITLE: Personalizing Class I anti-Arrhythmic Drug Therapy

STUDY_SECTION: ESTA

STUDY_SECTION_NAME: Electrical Signaling, Ion Transport, and Arrhythmias Study Section[ESTA]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Nanotechnology;Women's Health Research

ORG_CITY: BOSTON

ORG_DEPT: CHEMISTRY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Relevance to Public Health Dysregulation of epidermal growth factor receptor (EGFR) is indicated in a range of cancers, including basal-like breast cancer (BLBC). The project “Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor Signal Transduction Pathway Using Plasmon Coupling” develops nanoparticle-based tools to resolve dynamic spatial receptor clustering and to control the spatial regulation of EGFR activity. Nanoparticle-based strategies that facilitate the regulation of EGFR signaling provide new opportunities for therapeutic intervention in EGFR overexpressing cancers and can improve patient outcomes.

PI_NAMEs: REINHARD, BJOERN MARKUS (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: Address;Affect;Apoptosis;Binding;Biochemical;Breast Cancer Cell;Cell membrane;cell motility;chemotherapy;Coupling;Darkness;Data;Detection;Diffusion;Dimensions;dimer;Dimerization;Dyes;Elements;enhancing factor;Ensure;Epidermal Growth Factor;Epidermal Growth Factor Receptor;Epithelium;extracellular;fighting;Fluorescence;Fluorescence Microscopy;Gene Expression;Generations;Growth Factor Inhibition;Hydrogen Peroxide;Image;Imaging Device;improved;Individual;inhibitor;Integral Membrane Protein;Label;Lateral;Ligand Binding;Ligands;light microscopy;Lighting;Malignant Breast Neoplasm;Malignant Neoplasms;MAPK8 gene;Maps;Mediating;Membrane;Mesenchymal;Metastatic breast cancer;Microscopy;Modeling;Molecular Conformation;N-terminal;nanoGold;nanometer;nanoparticle;Nitric Oxide;Optics;Outcome;overexpression;Patient-Focused Outcomes;Phosphorylation;Phosphotransferases;plasmonics;Proliferating;Property;Protein Dynamics;Protein Tyrosine Kinase;Public Health;Reaction;Reactive Oxygen Species;receptor;Receptor Activation;receptor binding;Receptor Signaling;Regulation;Reporting;Research;response;Risk;Role;Sampling;Second Messenger Systems;Signal Transduction;Signal Transduction Pathway;Specificity;Structural Models;Structure;superresolution microscopy;targeted treatment;Technology;temporal measurement;Testing;Therapeutic;Therapeutic Intervention;Time;time use;tool;Treatment Failure;tumor progression;With laterality

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cardiovascular;Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: TOLEDO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

ORG_STATE: OH

PHR: Project Narrative  Several approaches are being pursued to address the opioid epidemic, including the development of new pain management strategies and limiting illicit transport/sale of narcotics. Nonetheless, synthetic opioids will likely continue to be abused substances for the foreseeable future. This work focuses on the identification of novel counter-measures capable of reversing overdose from synthetic opioids.

PI_NAMEs: SCHIEFER, ISAAC T (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: addiction;Address;alpha-adrenergic receptor;American;antagonist;Behavioral;Binding;Biodistribution;Biological Assay;Biological Process;blood-brain barrier penetration;bone;Cardiovascular Physiology;Cardiovascular system;Central Nervous System Agents;Cessation of life;Chemicals;Cholinergic Receptors;Classification;Clinical;competitive environment;Complex;Data;Descriptor;design;Development;Dose;Drug Modelings;Drug usage;Effectiveness;Ensure;Exhibits;Fentanyl;fentanyl exposure;fentanyl use;follow-up;Follow-Up Studies;Future;G-Protein-Coupled Receptors;Goals;Heart Rate;Heroin;high reward;high risk;high throughput screening;Human;Hydrocodone;improved;in silico;in vivo;innovation;Larva;lead optimization;Libraries;Lung;Measures;Mechanics;Mediating;Medical;Mental Depression;meter;Molecular Weight;Morphine;Motor Activity;mu opioid receptors;Naloxone;Narcotics;Natural Products;New Agents;novel;Opiate Addiction;Opioid;Opioid Antagonist;opioid epidemic;opioid overdose;Opioid Receptor;Outcome;Overdose;Overdose reversal;Pain management;Pharmaceutical Preparations;Phase;Phenotype;Probability;Property;Research;Respiratory distress;response;Risk;Sales;scaffold;screening;sedative;Site;small molecule;social;success;synthetic opioid;Testing;Travel;United States;uptake;Work;Zebrafish

PROJECT_TITLE: Zebrafish Screens to Identify Agents which Reverse the Effects of Synthetic Opioids

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-F(54)]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Epilepsy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Seizures are a common complication of intracranial hemorrhage. However, prophylactic antiseizure medications do not improve outcome because they are imprecisely administered. This proposal will identify patients at risk for seizures from electroencephalography and neuroimaging data.

PI_NAMEs: NAIDECH, ANDREW M (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Affect;Algorithms;American;Anticonvulsants;Brain;Brain Injuries;Brain region;Cerebral hemisphere hemorrhage;Cessation of life;Clinical;Clinical Data;clinical practice;clinical predictors;Clinical Trials;cognitive function;Complication;Data;Data Set;data warehouse;Databases;deep learning;diverse data;Effectiveness;Electroencephalography;Electronic Health Record;Epilepsy;follow-up;functional outcomes;Future;gradient boosting;Guidelines;Hand;Handedness;health related quality of life;Healthcare Systems;Heart Arrest;Hematoma;Hemorrhage;high risk;High-dimensional Modeling;Human;Image;improved;inferential statistics;innovation;Intracranial Hemorrhages;Levetiracetam;Lobar;Location;Machine Learning;Methods;Modeling;multidisciplinary;multimodality;Natural Language Processing;neuroimaging;Non-Convulsive Status Epilepticus;Outcome;Patient Selection;Patient-Focused Outcomes;Patients;Pattern Recognition;Periodicity;Pharmaceutical Preparations;Phenytoin;predictive modeling;prevent;prophylactic;prospective;Publications;Quality of Life Assessment;Recommendation;Reporting;Research;Risk;Risk Factors;Seizures;side effect;Source;Subarachnoid Hemorrhage;targeted treatment;Techniques;Temporal Lobe;Testing;Time;Traumatic Brain Injury;Update;Work

PROJECT_TITLE: Precise Prediction and Treatment of Seizures After Intracranial Hemorrhage

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: LM

ED_INST_TYPE: SCH OF BUSINESS/PUBLIC ADMIN

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: TUCSON

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Improving health literacy is an important national goal and necessary for achieving and maintaining health. The increased adoption of smart speakers and virtual assistants by consumers and in medical settings has created novel opportunities to educate the population by delivering health information through audio or audio combined with text. Because few (if any) tools exist to improve content and generate optimal audio, we aim to discover supportive and adverse features of audio/text information provision and create a free, online software tool for optimizing health-related text with demonstrated impact on information comprehension and retention.

PI_NAMEs: LEROY, GONDY  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Accent;Adoption;Affect;Affordable Care Act;Age;application programming interface;Arizona;Characteristics;clinical encounter;clinical practice;clinically relevant;Collaborations;Communication;Communities;Comprehension;Computer software;Computers;cost effective;Data;design;Development;digital;Educational Materials;Effectiveness;Evaluation;experience;Frequencies;Gender;General Population;Generations;Goals;Government;Growth;Guidelines;handheld mobile device;Health;health literacy;Healthcare;Hospitals;Household;improved;Information Dissemination;information gathering;information processing;innovation;intelligent personal assistant;interactive tool;large scale data;Machine Learning;Measures;Mechanics;Medical;Medical Education;Methods;Modeling;Natural Language Processing;Neighborhood Health Center;novel;open source tool;Outcome;Pamphlets;Participant;Patient Education;patient oriented;Patients;Pilot Projects;Population;preference;Printing;programs;real world application;recruit;Research;Research Personnel;Resources;skills;smart speaker;Software Tools;Source;Specific qualifier value;Speed;statistical and machine learning;symposium;Technology;Testing;Text;tool;Update;Voice;web based software;web site;Work;Work Simplification;Writing

PROJECT_TITLE: Audio Generation and Optimization from Existing Resources for Patient Education


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: Public health relevance Substance abuse disorders are devastating diseases and there are very few treatments available. This proposal will help uncover the molecular mechanisms in reward-related brain circuits that regulate diurnal rhythms in drug reward and help determine the optimal targets for future therapeutic treatments.

PI_NAMEs: MCCLUNG, COLLEEN A (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: addiction;Alcohols;Beer;Behavior;Binding;Brain;Brain region;candidate identification;cell type;Cells;cholinergic;Chronic;circadian;circadian pacemaker;Circadian Rhythms;Cocaine;cocaine self-administration;Darkness;Data;Disease;Diurnal Rhythm;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;DRD2 gene;Drug Exposure;drug of abuse;Drug Regulations;drug reward;Drug usage;Electrophysiology (science);Exposure to;extracellular;Family;Female;Future;Gene Mutation;Genes;Genetic;genetic manipulation;Genetic Transcription;Individual;Interneurons;knock-down;Light;male;Messenger RNA;Molecular;Mus;mutant;Mutant Strains Mice;Mutation;N-Methylaspartate;neuronal excitability;Neurons;Nucleus Accumbens;Pathway interactions;Pattern;Periodicity;Persons;Pharmaceutical Preparations;Phase;Phenotype;Pilot Projects;Play;Potassium Channel;preference;prevent;Proteins;Public Health;public health relevance;Rattus;response;reward circuitry;Rewards;Ribosomes;RiboTag;Role;Self Administration;sex;Sex Differences;Slice;small hairpin RNA;Sodium Channel;Structure;Substance abuse problem;Substance Use Disorder;Synapses;Testing;Therapeutic;Time;Transcript;transcriptome;transcriptome sequencing;Translating;Variant;Viral;Wine

PROJECT_TITLE: Diurnal rhythms in the nucleus accumbens: Mechanisms and role in substance use disorders


NIH_SPENDING_CATS: Behavioral and Social Science;Data Science;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Predict to Prevent: Dynamic Spatiotemporal Analyses of Opioid Overdose to Guide  Pre-Emptive Public Health Responses NARRATIVE Novel spatiotemporal forecasting models that rely on massively linked administrative data are needed to forecast future opioid overdose spikes and assess public health intervention success. Guided by the social ecological model, we plan to develop a comprehensive approach to identify individual, interpersonal, community and societal factors that contribute to opioid overdose, efficiently detect overdose hotspots, and develop dynamic forecasting models for timely prediction and prevention of future opioid overdose epidemics. We will disseminate blueprints, visualization tools, and code to other jurisdictions to facilitate replication of our approach.

PI_NAMEs: BAUER, CICI ;STOPKA, THOMAS J (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: addiction;Address;Adopted;Affect;Area;Authorization documentation;Autopsy;Biometry;Clinical;Code;Collaborations;Communities;community academic partnership;community advisory board;community intervention;community-level factor;Country;COVID-19 pandemic;dashboard;Data;Data Science;Data Set;data warehouse;Death Records;Decision Making;Detection;Dimensions;drug abuse prevention;Early Diagnosis;effectiveness evaluation;Effectiveness of Interventions;Ensure;Epidemic;Epidemiology;Etiology;Evaluation;evidence base;experience;Flare;Fostering;Future;Geography;Goals;Government;healing;Hospitals;implementation science;improved;Individual;innovation;insight;instrument;Intervention;intervention effect;Knowledge;Link;Lived experience;Location;Massachusetts;Measures;Medicine;member;Modeling;models and simulation;National Institute of Drug Abuse;novel;opioid epidemic;opioid mortality;opioid overdose;Outcome;Output;Overdose;overdose death;overdose prevention;Pattern;Policies;Policy Maker;Population;population health;Population Surveillance;Positioning Attribute;predictive modeling;prescription monitoring program;prevent;Prevention;Public Health;Public Health Informatics;public health intervention;Public Health Practice;Research;Resource Allocation;response;Risk;Role;simulation;social;social health determinants;Societal Factors;socioeconomics;Source;spatiotemporal;Spottings;Strategic Planning;success;Technical Expertise;Time;tool;Toxicology;Update;Validation;Visualization;Visualization software;Vulnerable Populations;Work

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Genetics;Human Genome;Pediatric;Prevention

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Building upon successful discovery and replication, we will sequence HLA/KIR/FcGR/IGHG genes in a prospective birth cohort, in which the seroconversion times have been precisely determined through frequent collection of biospecimens from all participants. Our objective is to estimate penetrance of discovered residues to the disease progression, and further to conduct mechanistic investigations. Success of this project will shed light on the genetic mechanisms underlying disease progression, and results will provide a roadmap to develop effective prevention and treatment strategies, decelerating and possibly reverting the disease development.

PI_NAMEs: GERAGHTY, DANIEL E.;LERNMARK, AKE ;ZHAO, LUE PING  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Acceleration;Alleles;Animals;Antigens;Autoantibodies;Autoantigens;Autoimmune Diseases;autoreactivity;B-Lymphocytes;Beta Cell;Biological Markers;Birth;C-Peptide;Case/Control Studies;Cell Physiology;Cells;Childhood;CISH gene;Clinical;clinical diagnosis;Clinical Research;cohort;Collection;cytotoxic CD8 T cells;Data;Deceleration;Dependence;Development;Diabetes Mellitus;Diabetes prevention;Diagnosis;Disease;Disease Progression;DNA;Elements;Etiology;fighting;Funding;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic association;Genetic Polymorphism;Genetic Predisposition to Disease;genome wide association study;Genotype;Glucose;glycemic control;Glycosylated hemoglobin A;Grant;Haplotypes;hazard;health management;high risk;HLA Class I Genes;HLA-DQ Antigens;HLA-DQB1;Human;Immune;Immunogenetics;Immunoglobulin G;Immunotherapy;Impairment;Incidence;Individual;Infection;insight;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;International;Investigation;islet cell antibody;Islets of Langerhans;Knowledge;Learning;Lymphocytic Infiltrate;Matched Case-Control Study;Measurement;Measures;Mediating;Methods;MHC Class II Genes;Molecular Conformation;molecular modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Natural Killer Cells;next generation;novel;Nucleic Acid Regulatory Sequences;Nucleotides;OGTT;Oral;Participant;Pathogenesis;Pathway Analysis;patient population;Penetrance;Peptide Signal Sequences;Peptides;Pilot Projects;Plasma Cells;Play;Prevalence;Prevention;Prevention Research;Prevention strategy;Prevention trial;Process;Production;Property;prospective;Public Health;recruit;Regulatory Element;Research;Resolution;Risk;Role;Sampling;screening;seroconversion;small molecule;success;T-Lymphocyte;targeted sequencing;Technology;Testing;Therapeutic;Time;transcriptome sequencing;transgene expression;translational impact;Translational Research;treatment strategy

PROJECT_TITLE: Characterizing Immunogenetics in Type 1 Diabetes

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative In the past decade, private equity firms have acquired numerous substance use disorder (SUD) treatment facilities. Similar acquisitions in other areas of health care have resulted in declines in quality and increases in mortality. This project examines the effects of private equity acquisition of SUD treatment facilities on treatments offered, the insurance mix of patients treated, opioid use disorder treatment quality and health outcomes.

PI_NAMEs: BUSCH, SUSAN H (contact);KING, MARISSA D

PROGRAM_OFFICER_NAME: HAEGERICH, TAMARA

PROJECT_TERMS: addiction;Adolescent;Adult;Adverse event;Area;authority;Buprenorphine;care delivery;care outcomes;Catalogs;Communities;Complex;Data;Databases;Directories;Emergency department visit;Equity;Faculty;follow-up;Future;Goals;Health;health care quality;Health Insurance;Health Services Accessibility;Healthcare;Healthcare Systems;improved;Individual;Industry;Insurance;Insurance Coverage;Marketing;Medicaid;medical schools;medical specialties;medication for opioid use disorder;Medicine;member;Methadone;Methodology;mortality;Nature;Newsletter;novel;Nurses;Nursing Homes;Opioid;opioid use disorder;Outcome;Ownership;Patient-Focused Outcomes;Patients;Peer Review;Pharmacy facility;Physicians;Policies;Policy Analysis;policy implication;Positioning Attribute;pressure;primary care services;Privatization;Public Health;Quality of Care;Quasi-experiment;Regulation;Reporting;Research;Research Design;Review Literature;Services;Source;Structure;Substance Use Disorder;substance use treatment;Time;treatment center;Work

PROJECT_TITLE: Substance use disorder treatment centers and facility ownership changes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Prevention;Rare Diseases

ORG_CITY: FORT WORTH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

PHR: PROJECT NARRATIVE Keratoconus (KC) disease is the degeneration of the corneal stroma, which causes the cornea to slowly change from its’ normal curved shape to a more conical shape, leading to vision distortion. The role of the KC tear fluid has been widely explored for biomarkers, however the presence and impact of the tear Extracellular Vesicles (EVs) remains unknown. The proposed studies have potential to discover novel biomarkers and pave the way for new diagnostic/treatment approaches.

PI_NAMEs: KARAMICHOS, DIMITRIOS  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Affect;Affinity;Age;Astigmatism;Bilateral;Biogenesis;Biologic Characteristic;Biological;Biological Markers;Biology;Biomechanics;Blood;Body Fluids;candidate marker;Categories;Cell Communication;Cell secretion;cell type;Cells;Chronic;Clinical;Clinical Research;clinically relevant;cohort;Collection;Communication;Complex;Cornea;Corneal Diseases;Corneal dystrophy;corneal epithelial wound healing;Corneal Stroma;Country;Data;Data Analyses;Diabetes Mellitus;Diagnosis;Disease;DNA;early detection biomarkers;Early Diagnosis;Endosomes;Environmental Risk Factor;Equipment;Event;exosome;Extracellular Space;extracellular vesicles;Eye diseases;eye dryness;Female;Fingerprint;Future;Gender;Genetic;Goals;Hormonal;Human;innovation;insight;Investigation;Keratoconus;Keratoplasty;Link;Lipid Bilayers;Lipid Binding;Lipids;Liquid substance;male;Malignant Neoplasms;Mediating;Mediator;Messenger RNA;Metabolic;microRNA biomarkers;MicroRNAs;Modality;Molecular;Monitor;Morphology;multidisciplinary;Nervous System Disorder;novel;novel diagnostics;novel marker;novel strategies;Nucleic Acids;Organ;particle;Pathogenesis;Pathological Dilatation;Patients;Persons;Phenotype;Physiological Processes;Plasma;Postoperative Complications;Prognosis;protein biomarkers;Proteins;Proteomics;Public Health;recruit;Reporting;Research Priority;Resources;Risk;Role;Saliva;sample collection;screening;Serum;Severities;Severity of illness;sex;Shapes;Signal Transduction;Site;Sjogren's Syndrome;Source;standard care;Testing;Therapeutic;Thinness;Time;Tissues;tool;Translating;Untranslated RNA;Urine;Vesicle;Vision;Visual impairment;Work

PROJECT_TITLE: The role of extracellular vesicles in keratoconus pathogenesis


ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Protein-protein interactions (PPIs) are critical for cell signaling, growth, proliferation and apoptosis. The work will develop novel strategies that specifically disrupt medicinally relevant β-catenin/BCL9 and β-catenin/TCF PPIs, and thereby leading to a new generation of therapeutic agents with novel molecular framework targeting Wnt singling. The designing strategy could guide the development of a new class of unnatural peptidic foldamer targeting a myriad of medicinally relevant PPIs.

PI_NAMEs: CAI, JIANFENG  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: 3-Dimensional;Adopted;alpha helix;Antineoplastic Agents;Apoptosis;B-Cell Lymphomas;beta catenin;Binding;Biological Assay;Biological Process;Biology;cancer type;cell growth;Cell Proliferation;Cells;Chemicals;Chemistry;Co-Immunoprecipitations;Complex;cytotoxicity;Data;design;Development;Disease;DNA;embryo tissue;Embryonic Development;Foundations;Future;Generations;Goals;Growth;Homeostasis;Human;Hyperactivity;improved;In Vitro;in vivo;Inhibition of Cancer Cell Growth;inhibitor;innovation;Knowledge;Lead;Learning;Link;Literature;Medicine;meter;mimetics;Modeling;Modification;Molecular;Molecular Probes;Mus;novel;novel anticancer drug;novel strategies;Penetration;Peptides;peptidomimetics;Permeability;Pharmaceutical Chemistry;Play;Proliferating;protein complex;protein protein interaction;Proteins;Publications;rational design;Reporting;Resistance;Reverse Transcriptase Polymerase Chain Reaction;Role;scaffold;Secure;Series;Side;Signal Pathway;Signal Transduction;small molecule;Solid;Specificity;Spectrum Analysis;Structure;subcutaneous;targeted agent;targeted treatment;TCF Transcription Factor;Tertiary Protein Structure;Therapeutic Agents;Transcriptional Activation;tumor;tumor growth;tumor progression;tumor xenograft;Vertebral column;WNT Signaling Pathway;Work;Xenograft Model

PROJECT_TITLE: Targeting Wnt signaling pathway


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Immunotherapy;Orphan Drug;Rare Diseases

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: PROJECT NARRATIVE Immunotherapy is now first line treatment in recurrent or metastatic head and neck cancer, yet the majority of patients do not respond. The proposed research aims to elucidate how the composition and spatial architecture of the head and neck cancer tumor immune microenvironment impacts response to immunotherapy, and how it changes across time following immunotherapy exposure. This knowledge is critical to improve treatment selection, develop new therapeutics and ultimately, improve survival outcomes for patient suffering from Head and Neck Cancer.

PI_NAMEs: FADEN, DANIEL  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Architecture;B-Lymphocytes;Bioinformatics;Biological Markers;Biopsy;cancer care;Cancer Center;cancer genomics;cancer type;career development;CD8B1 gene;Cell Communication;Cell Death;Cell Physiology;Cells;cellular imaging;Clinical;cohort;combinatorial;Development;Disease;Doctor of Philosophy;Down-Regulation;Ear;Ensure;Environment;Evolution;experience;Eye;Five-Year Plans;Gene Expression Alteration;General Hospitals;Genes;Genomics;Goals;Hand;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and Neck Surgery;Image;imaging approach;imaging platform;Immune;Immune checkpoint inhibitor;Immunogenomics;Immunotherapy;improved;innovation;instructor;Knowledge;Ligands;liquid biopsy;Liquid substance;Malignant Neoplasms;Massachusetts;Measures;medical schools;Mentors;Mentorship;Methods;Microfluidics;Molecular;Monitor;MS4A1 gene;Neoplasm Circulating Cells;neoplastic cell;novel;novel therapeutics;Organizational Change;Otolaryngology;Pathway interactions;Patient-Focused Outcomes;Patients;predictive marker;pressure;programs;Protocols documentation;Qualifying;Recurrence;Regimen;Research;Research Personnel;Resistance;Resolution;response;Retrospective cohort;Sampling;Science;Selection for Treatments;single cell sequencing;single-cell RNA sequencing;solid state;Spatial Distribution;spectrograph;Surgeon;survival outcome;T-Cell Activation;T-Lymphocyte;Technology;tertiary lymphoid organ;Testing;Therapeutic;therapeutic target;therapy resistant;Time;Tissues;Training;Training Programs;transcriptome;transcriptome sequencing;treatment response;tumor;tumor immunology;tumor-immune system interactions

PROJECT_TITLE: Dissecting temporal and spatial dynamics of immunotherapy resistance

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Cardiovascular;Diabetes;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE Cardiovascular disease is the leading cause of death in type 2 diabetic patients, which is directly associated with the degree of coronary disease. While impaired coronary function and hardening of the arteries have been well- studied contributors to coronary artery disease, the molecular mechanisms of coronary blood vessel function in diabetes-induced heart disease remains unknown. The proposed research will improve our fundamental understanding of the molecular mechanisms underlying coronary blood vessel disease, and it will contribute to the identification of new treatments for diseases of the coronary circulation in diabetes.

PI_NAMEs: GARG, VIDU ;TRASK, AARON J (contact)

PROGRAM_OFFICER_NAME: FLEG, JEROME L

PROJECT_TERMS: Arteries;Atherosclerosis;Biomechanics;Blood flow;Blood Vessels;Cardiovascular Diseases;Cause of Death;Cell Communication;Cell Physiology;Cells;Coculture Techniques;Communication;Coronary;Coronary Arteriosclerosis;Coronary Circulation;Coronary heart disease;Data;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;Disease;Early identification;early onset;Echocardiography;Elasticity;Endothelial Cells;endothelial dysfunction;Event;experience;experimental study;Family suidae;Genetic;Heart;Heart Diseases;heart function;Histone Acetylation;Histone Deacetylase;Impairment;improved;In Vitro;in vivo;Insulin;Knockout Mice;Ligands;Mediator;Metabolic syndrome;Microvascular Dysfunction;Modeling;Molecular;mouse model;Mus;Myocardial Infarction;Myography;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;notch protein;Notch Signaling Pathway;NOTCH3 gene;overexpression;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;PIK3CG gene;pressure;prevent;Proto-Oncogene Proteins c-akt;Publishing;receptor;Research;Resistance;Risk;Role;Severities;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;Testing;Therapeutic;transcriptomics;Transgenic Organisms;Type 2 diabetic;Vascular Endothelial Cell;Vascular remodeling;Vascular Smooth Muscle;Work

PROJECT_TITLE: The Role of Notch Signaling in Type 2 Diabetic Coronary Microvascular Disease

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Heart Disease - Coronary Heart Disease;Nutrition;Obesity;Prevention

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Aspirin’s effectiveness in preventing heart attacks and strokes decreases as a person’s weight increases, but we do not understand the reasons for this. We will test whether higher doses of aspirin are better at producing anti-inflammatory molecules as body weight increases and whether levels of these molecules can predict heart attacks, strokes and death. Our results will improve our understanding of cardiovascular disease in overweight and obesity and may suggest new treatment strategies for the prevention of heart attacks, strokes and death in people with cardiovascular disease.

PI_NAMEs: HEFFRON, SEAN PATRICK (contact)

PROJECT_TERMS: Acceleration;Acetylation;Adult;Aftercare;Age;American;Anti-Inflammatory Agents;Arterial Fatty Streak;Aspirin;Atherosclerosis;Bioinformatics;Blood;Blood Platelets;Body Weight;burden of illness;Cardiometabolic Disease;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;case control;Cell Communication;Cell Physiology;Cells;Cessation of life;Chronic;Clinical Research;cohort;Collaborations;Complement;Cross-Over Studies;Cross-Over Trials;cyclooxygenase 1;Cytochrome-c Oxidase Deficiency;Data;design;Dose;Effectiveness;Endothelial Cells;Endothelium;Event;Exhibits;experimental study;FPR2 gene;Future;Health;Human;Immune;Impairment;improved;improved outcome;individualized medicine;Inflammation;Inflammatory;Leukocytes;Leukotrienes;lipid mediator;lipoxin A4;Measures;Mediating;Mediator;Meta-Analysis;Modeling;monocyte;Mus;Myocardial Infarction;Myocardial Ischemia;neutrophil;novel;novel therapeutic intervention;Obesity;Outcome;Overweight;Patients;Peripheral arterial disease;Persons;Placebo Control;Placebos;Platelet aggregation;Platelet Aggregation Inhibition;platelet function;pre-clinical;Pre-Clinical Model;prevent;Prevention strategy;Primary Prevention;Production;Property;prospective;Prostaglandins;PTGS2 gene;Race;Randomized;Randomized, Controlled Trials;receptor;Regimen;Regulation;Resolution;response;Risk;Risk Reduction;RNA;Role;Secondary Prevention;Serum;Severities;sex;Smooth Muscle Myocytes;Stroke;Stroke prevention;Surface;Testing;Thrombosis;Thromboxanes;Time;Tissues;Vascular Diseases;Weight Gain;Work

PROJECT_TITLE: Aspirin-triggered Specialized Pro-resolving Mediators in Increasing Weight and Atherosclerotic Cardiovascular Disease

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative This proposal aims to enhance our mechanistic insights of vascular disease by focusing on a novel biological pathway, the sulfatase family, that contributes to the development of calcified arteries and plaque development in the blood vessels of humans. Furthermore, we aim to uncover new determinants of coronary artery disease using human genetic analysis. Success in identifying novel molecular and genetic pathways implicated in the development of calcification and plaque formation will provide new potential targets for the prevention and treatment of heart attacks, stroke, and peripheral arterial disease.

PI_NAMEs: DE VRIES, PAUL STEFAN;MALHOTRA, RAJEEV  (contact)

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: abdominal aorta;Affect;African American;Agatston Score;Aorta;aortic valve;Arteries;Arylsulfatases;Atherosclerosis;Autophagocytosis;biobank;Biological;Biological Assay;Blood Vessels;Bone Morphogenetic Proteins;calcification;Calcium;calcium phosphate;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cells;Clinical;Cohort Studies;Coronary;Coronary Arteriosclerosis;Coronary artery;coronary artery calcification;coronary artery calcium;Data;density;Deposition;Development;Disease;Electronic Health Record;Esters;Event;experimental study;Extracellular Matrix;Family;Genetic;genetic analysis;genetic association;Genetic Determinism;Genetic Polymorphism;genetic variant;genome wide association study;genomic locus;high risk;Homologous Gene;Human;Human Genetics;Human Genome;improved;In Vitro;in vitro Model;in vivo;in vivo Model;indexing;Individual;insight;Link;Measures;Mediating;member;Messenger RNA;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Infarction;novel;osteogenic;Outcome;overexpression;Participant;Pathway interactions;Peripheral arterial disease;Phenotype;Play;prevent;Prevention;Protein Family;Proteins;Risk;Risk Factors;Role;Series;Signal Pathway;Signaling Protein;Single Nucleotide Polymorphism;Smooth Muscle Myocytes;Stroke;success;Sulfatases;Sulfate;Testing;Thoracic aorta;Tissues;Trans-Omics for Precision Medicine;transcription factor;Variant;Vascular calcification;Vascular Diseases;Vascular Smooth Muscle;X Chromosome

PROJECT_TITLE: The Role of Arylsulfatase in Vascular Calcification


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE The ERG oncoprotein is responsible for half cases of prostate cancer, the most frequent cancer and the second leading cause of cancer death among American men. Prostate cancer features a luminal cell identity which is effectively targeted by hormone therapy, but resistance invariably occurs, thus demanding a deeper understanding of the biology underlying the cancer cell identity. This proposal seeks to elucidate the mechanisms and vulnerabilities of ERG-driven luminal cell identity during prostate cancer formation, the completion of which may reveal new treatment paradigms.

PI_NAMEs: FENG, WEIRAN  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Address;Adenocarcinoma;Advisory Committees;American;androgen deprivation therapy;anti-cancer research;ARNT gene;Aryl Hydrocarbon Receptor;Basal Cell;Biology;cancer cell;Cancer Etiology;cancer invasiveness;cancer subtypes;career;career development;Castration;Cells;Cessation of life;Chemicals;Chromatin;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Communication;Computational Biology;CRISPR screen;Data;Dependence;Development Plans;Dimerization;Environment;Epithelial Cells;Epithelium;Faculty;Foundations;Gene Fusion;Genetic;Genetically Engineered Mouse;genome wide screen;genome-wide;Goals;Grant;Histology;hormone therapy;Human;In Vitro;in vivo;Incidence;innovation;insight;Invaded;Knowledge;Leadership;Ligands;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Memorial Sloan-Kettering Cancer Center;men;Mentors;Mentorship;Modeling;Molecular;mouse model;multidisciplinary;Mus;novel;novel therapeutic intervention;Oncogenic;Oncoproteins;Organoids;Output;overexpression;Pathway interactions;patient subsets;Patients;Population;Positioning Attribute;progenitor;programs;Proliferating;Prostate;prostate cancer model;Prostatic;Receptor Signaling;Research;research and development;Residual state;Resistance;RNA;S-Phase Fraction;Sampling;Science;Signal Transduction;skills;Solid;Specific qualifier value;success;Testing;Therapeutic;tool;Training;transcription factor;translational cancer research;tumor;Work;Writing

PROJECT_TITLE: Mechanisms and vulnerabilities of ERG-driven luminal fate in prostate cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will allow better understanding of how gender- linked stress exposure and estrogen may interact to impact memory, peripheral inflammation, and neural activation and connectivity in women at risk for Alzheimer’s disease (AD). Knowledge gained from our study will provide a foundation for the further study of stress- and inflammation-based mechanisms of AD and will support the development of cost-effective AD risk reduction approaches for women that may decrease sex-based disparities in AD, which, in turn, should reduce the public health costs of AD. Our research plan aligns with the NIH priority of Advancing Science for the Health of Women, as well as the 2019-2023 Trans-NIH Strategic Plan for Women’s Health Research Strategic Goal 1 objective to identify immediate, mid-, and long-term effects of exposures on health and disease outcomes.

PI_NAMEs: KIRKLAND CALDWELL, JESSICA  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Address;Affect;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Anterior;Binding Sites;Biological;biological adaptation to stress;Biological Process;Brain;Cessation of life;Chromosomes;Chronic stress;Clinic;cost effective;cytokine;Development;Diagnosis;disease disparity;Disease Outcome;Disparity;Estradiol;Estrogen decline;Estrogens;evidence base;experience;Exposure to;Family;Female;Foundations;Functional Magnetic Resonance Imaging;Gender;gender disparity;Goals;Gonadal Steroid Hormones;Health;Health Care Costs;Health Sciences;High Risk Woman;Hippocampus;Impaired cognition;indexing;Individual;Inflammation;Inflammatory;innovation;interdisciplinary approach;Intervention;Knowledge;Link;Long-Term Effects;male;Measures;Mediating;Mediator;Memory;memory encoding;memory recognition;men;middle age;Midlife women;Modeling;Movement;neural;Neuropsychology;novel;Organ;Outcome;Patient Recruitments;Pattern;Peripheral;Persons;Plasma;Prevention;Process;Public Health;Recording of previous events;Reporting;Reproduction;reproductive organ;Research;Rest;Risk;Risk Factors;Risk Reduction;Scanning;sex;sex disparity;Sex Factors;Shapes;Strategic Planning;Stress;stressor;Structure;Symptoms;Task Performances;Temporal Lobe;therapy development;Translating;United States National Institutes of Health;verbal;Verbal Learning;Woman;Women's Health

PROJECT_TITLE: Interactions of Sex and Gender Factors in Risk for Alzheimers Disease: Links Between Stress, Neural Activity, Inflammation, and Memory


NIH_SPENDING_CATS: Atherosclerosis;Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Genome-wide association studies have identified over 200 independent loci that influence coronary artery disease (CAD) risk, yet determining the causal genes connecting genetic variation to disease susceptibility has lagged. Leveraging computational pipelines and machine learning models using large-scale functional genomic datasets, and scalable functional genomic screens with targeted validation, our study systematically identifies the functional regulatory elements that contain the risk variants and regulate the expression of target genes and phenotypic outcomes at CAD loci. Our results provide (1) novel insights into tissue/cell type-specific contributions to the genetic basis of CAD, and (2) an innovative computational and experimental framework for systematic variant-to-function discoveries.

PI_NAMEs: LI, WEI ;MARCORA, EDOARDO ;ZHANG, HANRUI  (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Acceleration;Address;Affect;Alleles;Apoptosis;Apoptotic;Atherosclerosis;Automobile Driving;Biological;Biological Assay;Biology;Blood Vessels;candidate identification;Catalogs;causal variant;Cause of Death;cell type;Cells;Cellular Assay;Chemotaxis;Chromatin;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;computational pipelines;Coronary Arteriosclerosis;CRISPR interference;CRISPR screen;Data;Data Set;Disease;Disease susceptibility;disorder risk;Drug Targeting;effective therapy;Encyclopedias;Endothelial Cells;epigenomics;Etiology;experimental study;Foam Cells;Foamy Macrophage;follow-up;functional genomics;Genes;Genetic;Genetic Predisposition to Disease;Genetic Variation;genome wide association study;genome-wide analysis;genomic data;Genomics;Human;Immune;improved;in vivo Model;induced pluripotent stem cell;innovation;insight;Knock-out;Link;Lipids;Lipoproteins;Machine Learning;machine learning model;machine learning prediction;Macrophage;Maps;Metabolic;monocyte;Nature;new therapeutic target;novel;Outcome;overexpression;Pathway interactions;Patients;Performance;Phagocytes;Phenotype;Regulatory Element;Reporter;Risk Factors;risk variant;Role;screening;single-cell RNA sequencing;Smooth Muscle Myocytes;Stimulus;success;Testing;Therapeutic;therapeutic target;Tissues;Training;transcriptomics;Translations;Untranslated RNA;uptake;Validation;Variant;Vascular Smooth Muscle

PROJECT_TITLE: Integrative genomic and functional genomic studies to connect variant to function for CAD GWAS loci


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Pediatric;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Public Health Relevance Disturbance in connections between different brain regions can contribute to neurological and psychiatric conditions, including vulnerability to drug abuse. We propose to use novel genetic tools, advanced imaging, and real time neural activity measurement to investigate how miswiring of the reward pathway influences additive behaviors.

PI_NAMEs: CHEN, ZHE  (contact);MEISEL, ROBERT L

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: addiction;Addictive Behavior;Adolescence;Adolescent Development;Affect;Anatomy;Animal Behavior;Area;Axon;axon guidance;Behavior;behavioral response;Brain;Brain imaging;Brain region;conditioned place preference;Cre lox recombination system;DCC gene;Dopamine;dopaminergic neuron;Drug abuse;drug abuse vulnerability;drug of abuse;Drug usage;emerging adult;Environmental Risk Factor;Exposure to;Fiber;functional outcomes;Genetic;genetic approach;Human;Image;in vivo;insight;Knowledge;Laser Scanning Confocal Microscopy;Ligands;Measurement;Medial;Mediating;Midbrain structure;Molecular;Mus;Mutation;neural;Neurologic;novel;Nucleus Accumbens;overexpression;Pathway interactions;Pharmaceutical Preparations;Photometry;Pilot Projects;Predisposition;Prefrontal Cortex;Protein Isoforms;Public Health;public health relevance;receptor;Regulation;Reporter;Resolution;response;Rewards;Risk Factors;Signal Transduction;Speed;Substance Addiction;substance use;Testing;Time;Tissues;tool;Variant;Ventral Tegmental Area

PROJECT_TITLE: VTA dopamine connectivity and functional responses to drugs of abuse

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_CITY: MEMPHIS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: Invasive aspergillosis is associated with high mortality rates in patients with suppressed or ineffective immune systems. Successful treatment of Aspergillus fumigatus infections is difficult, as only three classes of antifungal exist and clinical use of each is met with major limitations. Our research aims to enhance the anti-Aspergillus activity of the echinocandin class through targeting developmental mechanisms that shift echinocandin activity from static to cidal.

PI_NAMEs: FORTWENDEL, JARROD R. (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Anabolism;anti-fungal agents;Aspergillosis;Aspergillus;Aspergillus fumigatus;Azoles;biological adaptation to stress;Biological Assay;breakthrough infection;Cell Wall;Clinical;Combined Modality Therapy;Complex;Coupled;CRISPR/Cas technology;Cyclic AMP-Dependent Protein Kinases;Data;Death Rate;deletion library;Development;Effectiveness;Engineering;Exhibits;fungicide;fungus;Future;Generations;Genes;Genetic;Genome;Germination;Goals;high-throughput drug screening;Hyphae;Immune system;Immunocompromised Host;improved;In Vitro;in vivo;in vivo evaluation;Incidence;Individual;Infection;Injury;Intervention;Libraries;Mechanics;Mediator;Modeling;Molds;mouse model;mutant;Mutation;novel;Pathway interactions;Patients;Pharmaceutical Preparations;Phosphotransferases;Polyenes;Predisposition;programs;Protein Kinase;Reporting;Reproduction spores;Research;Residual state;Resistance;response;Septate;Stress;Structure;Therapeutic;Therapeutic Agents;Therapeutic Intervention;therapeutically effective;Tissues;Toxic effect;transcription factor;transcriptomics;treatment effect;Treatment Efficacy;Work

PROJECT_TITLE: Unlocking the cidal activity of echinocandins against Aspergillus fumigatus

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Aging;Cancer;Cardiovascular;Complementary and Integrative Health;Heart Disease;Mental Health;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Social Determinants of Health

PHR: Project Narrative:  The proposed research is relevant to public health because it will identify the mechanisms of chemotherapy-induced cardiotoxicity and find out how psychosocial stress aggravates chemotherapy-induced cardiovascular aging leading to severe heart disease. This will enable the development of highly effective therapies to prevent and/or reverse chemotherapy-induced cardiovascular complications in cancer survivors.

PI_NAMEs: ZORDOKY, BESHAY  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Adolescent;Aging;Animals;Anthracycline;Atherosclerosis;C57BL/6 Mouse;Cancer Survivor;cancer therapy;Cardiac;Cardiomyopathies;cardioprotection;Cardiotoxicity;Cardiovascular Diseases;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;CDKN1A gene;Cell Aging;Cell Line;Chemicals;chemotherapy;Child;childhood cancer survivor;Chronic;Clinical;clinically relevant;coronary fibrosis;Data;design;Development;Dose;Doxorubicin;effective therapy;Gene Expression;Goals;Heart;Heart Diseases;Heart failure;high risk;Immunocompetent;Inflammation;inflammatory marker;inhibitor;innovation;Interleukin-1;Interleukin-6;Knowledge;life span;Lymphoma;Lymphoma cell;Mediating;Modeling;Molecular;Molecular Target;mouse model;Mus;novel;Observational Study;p38 Mitogen Activated Protein Kinase;Pattern;Pharmaceutical Preparations;Phytochemical;Predisposition;premature;prevent;profibrotic cytokine;Psychosocial Stress;psychosocial stressors;Public Health;Publishing;Recovery;Research;Resveratrol;Risk;Risk Factors;Role;senescence;senescence associated secretory phenotype;senolytics;Sensory;Siblings;Signal Pathway;Stress;Stress cardiomyopathy;synergism;Testing;Therapeutic;Time;Tissues;tumor

PROJECT_TITLE: Psychosocial Stress Exacerbates Doxorubicin-induced Cardiovascular Aging

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Kidney Disease;Physical Activity;Prevention

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE The optimal approach to predicting cardiovascular risk in patients with chronic kidney disease (CKD) is unknown. Emerging evidence suggests that global indices of cardiovascular functional capacity (VO2Peak) may offer a potential solution for better risk stratifying patients with CKD using state-of-the-art cardiopulmonary exercise testing (CPET) technology. The present study will be the first to compare head-to-head CPET with clinically used diagnostic tools, and to develop a new risk stratification model for predicting cardiovascular outcomes in patients with advanced CKD stage 5D (on hemodialysis).

PI_NAMEs: LIM, KENNETH  (contact)

PROGRAM_OFFICER_NAME: SHANBHAG, SUJATA MADHUKAR

PROJECT_TERMS: Activities of Daily Living;Address;American;American Heart Association;Arteriosclerosis;Blood Vessels;calcification;Cardiac;Cardiology;Cardiopulmonary;Cardiovascular alteration;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cessation of life;Chronic Kidney Failure;Clinical;clinical practice;college;Coronary Angiography;coronary artery calcification;coronary fibrosis;Data;Diagnostic tests;diagnostic tool;Dialysis patients;Dialysis procedure;Discrimination;Echocardiography;Equipoise;ethnic diversity;Evaluation;Event;Exercise;exercise capacity;Exercise Test;Fibrosis;Future;Geometry;Head;Heart;Heart failure;Hemodialysis;Hypertrophy;Impairment;improved;indexing;Kidney Diseases;Kidney Transplantation;Left;Left Ventricular Mass;Link;Magnetic Resonance Imaging;Measurement;Measures;Medical;Modeling;Molecular;novel;Operative Surgical Procedures;Outcome;Oxygen;Patient Selection;patient stratification;Patients;Physical Function;Population;predictive modeling;predictive tools;Predictive Value;premature;prognostic value;prognostication;prospective;Prospective Studies;Provider;Publishing;pulmonary function;racial diversity;Recommendation;recruit;respiratory;response;Rest;Risk;Risk Assessment;risk prediction;risk prediction model;risk stratification;sarcopenia;Skeletal Muscle;Stress;Structure;System;Technology;Testing;tool;Uncertainty;uptake;Ventricular;Work

PROJECT_TITLE: Redefining cardiovascular risk assessment in dialysis patients (ROCK-D) study

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: HD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Infectious Diseases;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative We study how exposure to a major natural disaster affects health decision-making and outcomes: risky sexual behaviors (including transactional sex), whether to be tested for sexually transmitted infections (STIs), new STI infections, and COVID-19-related behaviors. In addition, we study how changes in preferences and psychological factors may mediate these effects, by taking measurements of risk preference, time preference, present bias, and motivated belief biases in our study population. Finally, we shed light on whether a public health program helps shield communities from the effects of the disaster on health decision-making.

PI_NAMEs: YANG, DEAN  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Affect;Africa;Area;Baseline Surveys;Behavior;behavioral economics;Belief;Child;Clinic;Communicable Diseases;Communities;Control Groups;COVID-19;Crime;Data;Decision Making;design;Deterioration;Developing Countries;Devices;Disasters;Disease;Economics;Education;Evaluation;Exposure to;follow-up;food security;frontier;Funding;Future;Health;Health Services;Heterogeneity;high risk sexual behavior;Household;Human;Hurricane;improved;Incidence;Income;Individual;Infection;insight;interest;Interruption;Intervention;Lead;Measurement;Measures;Mediating;Mediator;Mozambique;Natural Disasters;novel;optimism;Outcome;Persons;Pharmaceutical Preparations;Play;Policies;Population;Post-Traumatic Stress Disorders;Poverty;preference;Prevalence;programs;protective effect;Province;Psychological Factors;Psychology;Public Health;public health intervention;Randomized;Recovery;Regimen;Resistance development;response;Risk;Role;Running;Sampling;secondary outcome;Selection Bias;Sex Behavior;Sexual Transmission;Sexually Transmitted Diseases;Shock;Stress;study population;support network;Surveys;Testing;Time;tool;transactional sex;transmission process;treatment effect;treatment group;Unsafe Sex;Violence;Visit;Weather

PROJECT_TITLE: Health Decision-Making in the Aftermath of Disaster

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]