ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Public Health Relevancy Statement Gene expression is tightly controlled in time and space and is governed by protein-nucleic acid (DNA and RNA) interactions. There are hundreds of DNA- and RNA-binding proteins that regulate gene expression and many are mutated in disease, but we lack facile approaches to map these proteins to their DNA/RNA targets. Here we propose to develop an innovative set of tools that will give every molecular biology lab the possibility to obtain comprehensive cell-type specific protein DNA/RNA interaction maps, a necessity to understand gene expression regulation and therefore disease development.

PI_NAMEs: GUTTMAN, MITCHELL ;JOVANOVIC, MARKO  (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Address;Bar Codes;Binding;Binding Sites;Biological;Biological Assay;cell type;Cells;ChIP-seq;Chromatin;chromatin modification;Communities;cost;Development;Disease;disease model;DNA;DNA Binding;DNA-Binding Proteins;empowerment;epigenomics;Gene Expression;Gene Expression Regulation;Generations;genomic data;Genomics;Goals;High-Throughput Nucleotide Sequencing;histone modification;human disease;Individual;innovation;innovative technologies;insight;interest;International;Maps;Messenger RNA;Methods;Molecular Biology;mRNA Transcript Degradation;Mutate;Nucleic Acids;Population;Post-Translational Protein Processing;Process;Proteins;Public Health;Research;Research Personnel;RNA;RNA Binding;RNA Splicing;RNA-Binding Proteins;Sampling;Technology;Time;tool;Transcriptional Regulation;Translations

PROJECT_TITLE: Extensive multiplexing of protein nucleic-acid interactions to comprehensively study gene expression regulation from chromatin to mRNA degradation

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: Newark

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: NARRATIVE Patients with advanced solid tumors such as pancreatic ductal adenocarcinoma desperately need novel and effective therapeutics. Macrophage allotransplantation seems permissive, making them a safe choice as a “third- party, off-the-shelf” cell therapy option. The proposed research will not only examine macrophages genetically engineered with a chimeric antigen receptor targeting phosphatidylserine as a universal adjuvant cell therapy of KRAS inhibitors for pancreatic cancer treatment, but it will also enhance the understanding of macrophage self- renewal, plasticity, signaling transduction and function execution.

PI_NAMEs: HOU, PINGPING  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: adaptive immune response;Adjuvant;Adjuvant Therapy;allotransplant;anti-tumor immune response;Antigen-Presenting Cells;Antigens;antitumor effect;Apoptosis;Apoptotic;Biodistribution;Biological;cancer cell;cancer therapy;CCL2 gene;cell killing;Cell Line;Cell membrane;Cell Therapy;cell type;Cells;Charge;chimeric antigen receptor;Combined Modality Therapy;Consumption;cost;cytokine;cytotoxic;Development;Disease Progression;disorder control;Eating;Engineering;Flow Cytometry;functional plasticity;Genetic Engineering;genetic signature;Growth;Homeostasis;Human;Immune;immune function;Immune response;Immunocompetent;Immunophenotyping;Immunotherapy;Impairment;improved;in vitro Assay;Infiltration;Inflammatory;inhibitor;insight;Knowledge;KRAS oncogenesis;KRAS2 gene;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;manufacturing process;Mediating;Membrane;Modality;Molecular;monocyte;mouse model;Mus;Mutation;neoplastic cell;novel;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Patients;Penetration;peripheral blood;permissiveness;Phagocytes;Phagocytosis;Phenotype;phosphatidylserine receptor;Phosphatidylserines;Pilot Projects;preclinical study;prevent;programs;Reaction;recruit;Recurrence;Recurrent tumor;Regulation;Reporting;Research;Resistance;response;self-renewal;Signal Transduction;Solid Neoplasm;Specificity;Stress;Structure;suicide gene;synergism;System;systemic toxicity;T-Lymphocyte;targeted treatment;Therapeutic;therapeutically effective;Time;Tissues;Toxic effect;traditional therapy;transcriptome;tumor;tumor growth;tumor microenvironment;Tumor Suppression;tumor-immune system interactions;Validation;Writing;Xenograft Model

PROJECT_TITLE: Develop universal CAR macrophage cell therapy for pancreatic cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-8 (M1)]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: WORCESTER

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative The purpose of the NeuroImaging Tools and Resources Collaboratory (NITRC) is to provide neuroscience researchers with a complete solution to the problem of finding, developing, and sharing neuroimaging and neuroinformatics resources. NITRC will continue to be a place where researchers can identify software and data and seamlessly use them for image analysis. This will greatly enhance transparent and more reproducible research practices for the community.

PI_NAMEs: HASELGROVE, CHRISTIAN ;KENNEDY, DAVID NELSON (contact);PREUSS, NINA

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Administrator;Area;Award;Awareness;base;clinical conference;Clinical Trials;cloud based;collaboratory;Communities;community engagement;Computer software;computing resources;crowdsourcing;Data;Data Set;data sharing;Databases;design;Development;Documentation;Environment;experience;Funding;hackathon;High Performance Computing;Image;Image Analysis;image archival system;informatics tool;Infrastructure;innovation;Investments;large scale data;large-scale imaging data;Maintenance;Marketing;Minor;Mission;neuroimaging;neuroinformatics;Neurosciences;Neurosciences Research;Newsletter;operation;outreach;Positioning Attribute;Price;Production;program dissemination;Publications;R24;Registries;repository;Reproducibility;Research;Research Personnel;Resource Sharing;Resources;response;Secure;Services;Site;Slide;social media;Software Tools;Source;Spottings;stem;System;Technology;Testing;tool;Training;United States National Institutes of Health;Update;usability;virtual

PROJECT_TITLE: Neuroimaging Informatics Tools and Resources Collaboratory: Outreach, Infrastructure and Maintenance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-U (80)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Sleep Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Determining accurate models of the developing brain’s functional architecture during the first two years of life is necessary to make predictions about developmental and clinical outcomes. Crucially, developmental differences in sleep cycles between infants and toddlers and individual variability in time spent in each sleep stage pose a challenge for both understanding early brain development as well as mental health outcome prediction reproducibility and accuracy in extant pediatric, sleeping state fMRI studies such as the Baby Connectome Project, Developing Human Connectome Project, Early Life Adversity, Biological Embedding study, and Healthy Brain and Child Development study. Disentangling the relative contributions of sleep stage and age in early brain network development and decoding sleep stages in extant infant and toddler sleeping state fMRI data will be transformative, providing a state-based understanding of early developmental brain networks and a framework for accurate developmental outcome predictions.

PI_NAMEs: WHEELOCK, MURIAH D (contact)

PROGRAM_OFFICER_NAME: MACHLIN, LAURA STONER

PROJECT_TERMS: Adult;Age;Age Months;Algorithms;analysis pipeline;Architecture;Arousal;association cortex;Attention;Auditory;awake;Award;Behavioral;Biological;Biological Markers;Birth;Brain;Child;Child Development;Childhood;Clinical;cognitive function;Collection;connectome;Data;data acquisition;Data Analyses;Data Collection;Data Set;data standards;Development;Dorsal;early life adversity;Electroencephalography;emotional functioning;Excision;Functional Magnetic Resonance Imaging;Goals;Human;individual variation;Infant;Inflammation;Knowledge;lead exposure;Life;Light;Literature;Machine Learning;Manuals;maternal stress;Measures;Mental Health;Methods;Modeling;Morphologic artifacts;Motor;network models;non rapid eye movement;Older Population;Outcome;outcome prediction;Pathway Analysis;Play;predict clinical outcome;Premature Birth;Principal Investigator;Process;prognostic value;Psychopathology;rapid eye movement;Reproducibility;Research;Research Personnel;Rest;Role;Sampling;Sleep;Sleep Stages;Staging;success;support vector machine;Time;Toddler;Training;Universities;Visual;Wakefulness;Washington

PROJECT_TITLE: Leveraging pediatric state-specific functional brain network dynamics to predict developmental outcomes

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Suicide;Suicide Prevention

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

ORG_STATE: RI

PHR: Project Narrative Given that suicide is the second leading cause of death of children and adolescents, this study addresses the National Institute of Mental Health's call for greater understanding of the brain/behavior mechanisms underlying youth suicide. Specifically, we will use functional magnetic resonance imaging (fMRI) and real- world ecological momentary assessment (EMA) to advance what is known about the brain/behavior mechanisms underlying self-critical rumination (defined as persistent negative self-evaluation) and self- reassurance (providing compassion to self) in the context of youth suicide risk. Ultimately, greater understanding of these two constructs will facilitate the development of novel interventions targeting these symptom/circuit mechanisms related to youth suicide.

PI_NAMEs: KUDINOVA, ANASTACIA Y. (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 15 year old;Address;Adolescent;age group;Anterior;Behavior;Behavior assessment;Behavioral Mechanisms;biobehavior;Brain;career development;Cause of Death;Child;Collaborations;critical developmental period;Data;Development;Diagnostic;Dorsal;Ecological momentary assessment;Environment;experience;Feeling suicidal;Functional Magnetic Resonance Imaging;Goals;Human;Image;imaging approach;in vivo;innovation;Insula of Reil;Intervention;K-Series Research Career Programs;Mentors;Mentorship;Methodology;National Institute of Mental Health;neuromechanism;novel;Prefrontal Cortex;Prevention Research;preventive intervention;Price;Process;programs;Psychiatry;recruit;Research;rumination;Sampling;Self Assessment;self-compassion;Self-Examination;skills;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;Symptoms;Techniques;Teenagers;Testing;Training;Universities;Youth

PROJECT_TITLE: Neural Mechanisms Underlying Self-Critical Rumination and Self-Reassurance and Suicidal Thoughts and Behavior in Youth

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Rare Diseases

ORG_CITY: ROCK HILL

ORG_DEPT: BIOLOGY

ORG_NAME: WINTHROP UNIVERSITY

ORG_STATE: SC

PHR: PROJECT NARRATIVE Glioblastoma is a lethal tumor of the central nervous system with a median survival rate of less than fifteen months. The perturbation of gene expression patterns is a major driver of glioblastoma progression. Therefore, the overall goal of this project is to understand a novel gene regulatory network in glioblastoma cells that may enlighten development of additional, more effective therapies.

PI_NAMEs: STOVALL, DANIEL BROOKS (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;antitumor effect;Architecture;Astrocytes;Binding Proteins;Biological Assay;brain tissue;cancer type;Cell Differentiation process;Cell Line;cell motility;Cell Separation;Cell Survival;Cells;cellular transduction;Central Nervous System Neoplasms;Chemotherapy and/or radiation;ChIP-seq;Chromatin;Clone Cells;Data;Development;DNA;Ectopic Expression;effective therapy;Environment;Enzymes;Epigenetic Process;Family;Funding Mechanisms;Future;G-Quartets;Gene Abnormality;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene regulatory network;Gene Silencing;Genes;Genetic Transcription;Glioblastoma;Goals;Growth;In Vitro;inhibitor;insight;Invaded;knock-down;Knowledge;Lentivirus;Ligands;Lighting;Luciferases;Malignant - descriptor;Malignant neoplasm of central nervous system;Malignant Neoplasms;matrigel;Measures;Mediating;Mesenchymal;MicroRNAs;migration;Modality;Molecular;Molecular Target;Normal Cell;novel;Ontology;Pathway interactions;Patients;Phenotype;Play;Polycomb;programs;promoter;Protein Biosynthesis;protein expression;protein function;Proteins;radiation resistance;Recurrent disease;Regulation;Regulator Genes;Research;Resistance;RNA;RNA Interference;Role;Sampling;Shapes;small hairpin RNA;Structure;Survival Rate;targeted treatment;temozolomide;Testing;Therapeutic;transcription factor;Transcriptional Regulation;transcriptome sequencing;tumor;Tumor Suppressor Proteins;undergraduate student;Universities;Western Blotting;wound healing;YY1 Transcription Factor

PROJECT_TITLE: Determining the Mechanisms of RING1- and YY1-binding protein (RYBP) function and dysregulation in glioblastoma cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-T (SF)]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative: Cancer research is a strategic area of research at the University of Oklahoma Health Sciences Center. The overarching objective of COBRE Phase III is to provide continued support for cancer researchers in Oklahoma by bolstering the research infrastructure dedicated to cancer research. We anticipate that the endeavors undertaken through COBRE Phase III will propel groundbreaking advancements in cancer prevention and treatment, offering hope and transformative treatments to cancer patients in Oklahoma. 1

PI_NAMEs: DHANASEKARAN, DANNY N. (contact)

PROGRAM_OFFICER_NAME: NANDA, JAGPREET SINGH

PROJECT_TERMS: Achievement;Address;Advanced Malignant Neoplasm;Advisory Committees;Affect;American Cancer Society;anti-cancer research;Area;Award;Cancer Burden;Cancer Center;cancer diagnosis;Cancer Patient;cancer prevention;Cancer Research Infrastructure;cancer therapy;Centers of Research Excellence;clinical application;clinical practice;Collaborations;Communities;Community Outreach;Comprehensive Cancer Center;Core Facility;Data;Death Rate;Dedications;Department of Defense;design;Disease;Disparity;Economic Burden;Economics;Education;empowerment;Ensure;Etiology;Face;Fees;Fostering;Foundations;Funding;Future;global health;Goals;Grant;Growth;Health;health disparity;Health Sciences;High Prevalence;improved;Incidence;innovation;Institution;Lead;Leadership;Malignant Neoplasms;Mentors;Mentorship;Mission;Native American population;NCI-Designated Cancer Center;Newly Diagnosed;Oklahoma;Outcome;Paper;Personal Satisfaction;Phase;Pilot Projects;Play;Population;programs;Publications;Publishing;recruit;Research;research facility;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Role;rural area;Secure;Services;social;Special Population;Statutes and Laws;Strategic Planning;success;Talents;Therapeutic;translational cancer research;Translational Research;underserved area;United States National Institutes of Health;Universities;Vision

PROJECT_TITLE: Mentoring Translational Cancer Research in Oklahoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-X (C3)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer

PROJECT_TERMS: Achievement;Address;Adherence;Advanced Malignant Neoplasm;Advisory Committees;American Cancer Society;anti-cancer research;Automobile Driving;Cancer Center;Centers of Research Excellence;Collaborations;college;Committee Members;Communication;Communities;Comprehensive Cancer Center;Core Facility;Disease;effective therapy;empowerment;Ensure;Environment;Evaluation;Event;experience;Feedback;Fees;Fortification;Fostering;Foundations;Funding;Funding Agency;Goals;Grant;Health Sciences;improved;Infrastructure;innovation;Institution;Joints;Malignant Neoplasms;Medicine;meetings;Mentors;mid-career faculty;Mission;National Institute of General Medical Sciences;novel;Oklahoma;operation;Outcome;Patient Care;Phase;Pilot Projects;Play;Policies;Positioning Attribute;Process;professor;programs;Progress Reports;Public Health;Published Comment;recruit;Research;research facility;Research Infrastructure;Research Personnel;Research Project Grants;Resource Sharing;Resources;Role;Running;Science;scientific organization;Scientist;Series;Strategic Planning;success;symposium;Talents;translational cancer research;Travel;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: Admin Core


PI_NAMEs: JAYARAMAN, MURALIDHARAN  (contact)

PROJECT_TERMS: 3-Dimensional;Animal Model;animal tissue;anti-cancer research;Behavior;Binding;Biological;Blood Vessels;Board Certification;Cancer Biology;cancer cell;Cell Communication;Cell Proliferation;Cells;Centers of Research Excellence;Collaborations;combat;Computers and Advanced Instrumentation;Consultations;Core Facility;Cultured Cells;Dedications;Diagnostic;diagnostic biomarker;Disease;Ecosystem;effective intervention;empowerment;Enhancement Technology;Ensure;Environment;Experimental Designs;experimental study;Formalin;Fostering;Freezing;Genes;Genus Hippocampus;Gold;Human;Hypoxia;Immune;Immunohistochemistry;improved;In Situ Hybridization;Industry;Infiltration;innovation;insight;Intervention;Investigation;Investigational Therapies;Knowledge;Leadership;Light;Malignant Neoplasms;meetings;Mentors;Metabolic;Methodology;Methods;Mission;Modern Medicine;Molecular;molecular marker;Monitor;Mycoplasma;NCI Center for Cancer Research;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Oklahoma;Oxygen;Paraffin Embedding;Pathologist;Patient-Focused Outcomes;Phase;Play;Preparation;Procedures;prognostic;Research;Research Personnel;response;RNA;Role;Sampling;Science;Seasons;Services;Short Tandem Repeat;Slide;Specimen;Stains;System;Techniques;Technology;Testing;testing services;Therapeutic;tissue culture;Tissue Embedding;Tissue Microarray;Tissues;Training;translational cancer research;treatment response;tumor microenvironment

PROJECT_TITLE: Cell and Tissue Analysis Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer

PI_NAMEs: RAMESH, RAJAGOPAL  (contact)

PROJECT_TERMS: 3-Dimensional;Achievement;Address;Ally;Anatomy;animal imaging;Animals;anti-cancer research;Applications Grants;Behavior;Binding;Businesses;Cancer Biology;cancer cell;cancer imaging;Cancer Science;career;Cell Separation;Cells;cellular imaging;Centers of Research Excellence;Characteristics;Collaborations;Complex;complex data;Computer software;Consultations;Custom;Data;Data Set;Dedications;design;Dimensions;Disease;Disease Progression;empowerment;Ensure;Environment;Equipment;Experimental Designs;experimental study;Fostering;Funding;Gene Expression Profiling;Generations;Health Sciences;Heterogeneity;Image;Image Analysis;Imaging Device;imaging modality;imaging platform;imaging system;Imaging Techniques;Imaging technology;In Vitro;in vivo;in vivo imaging;in vivo Model;innovation;insight;Label;Laboratories;Leadership;live cell imaging;Malignant Neoplasms;Mentors;Microscope;Molecular;molecular imaging;Neoplasm Metastasis;Oklahoma;Organism;peer;Peer Review;Phase;Pilot Projects;Play;Process;Publications;real time monitoring;Research;Research Design;Research Personnel;Research Project Grants;research study;Resources;Role;Sampling;Scientific Advances and Accomplishments;Scientist;Secure;Services;Specialist;symposium;Techniques;therapeutic target;Time;Tissues;tool;trafficking;Training;translational cancer research;treatment response;tumor growth;Universities;Update;Visualization

PROJECT_TITLE: Cell and Molecular Imaging Core


ORG_CITY: GRAND FORKS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

ORG_STATE: ND

PHR: University Of North Dakota Epigenomics Of Development and Disease OVERALL PROJECT NARRATIVE The goal of this project is to facilitate the growth and sustainability of our Center of Biomedical Research Excellence “Epigenomics of Development and Disease” at UND. This will be achieved by supporting (1) a Pilot Project Program focused on epigenetic mechanisms in development and disease to bolster collaborative research, (2) a Genomics Core providing infrastructure and technology essential to our group and the wider research community, (3) an Administrative core to provide educational, oversight, and faculty development programs. These endeavors are poised to strengthen our group and enhance our ability to perform cutting- edge research with direct relevance to human health in the context of epigenetic mechanisms in disease and development.

PI_NAMEs: VAUGHAN, ROXANNE A (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Acceleration;Accountability;Area;Artificial Intelligence;Award;Centers of Research Excellence;Clinical;cohort;Collaborations;Communities;Data;Data Analyses;Dedications;Development;Disease;DNA Sequence;Dryness;Education;Educational workshop;empowerment;Epigenetic Process;epigenomics;Extramural Activities;Faculty;Faculty Recruitment;faculty support;Fee-for-Service Plans;Financial Support;Foundations;Funding;Funding Opportunities;Gene Expression;genomic tools;Genomics;Goals;Grant;Growth;Health;Heritability;Human;Human Development;human disease;Human Resources;Income;Individual;Infrastructure;innovation;interest;International;Journals;meetings;member;Mentors;Methodology;mid-career faculty;Molecular;Nature;next generation;next generation sequencing;North Dakota;Oral;Paper;Pathologic;Performance;Phase;Pilot Projects;Postdoctoral Fellow;posters;pre-clinical;Program Development;programs;Publishing;recruit;Research;Research Personnel;Research Project Grants;Resolution;Role;Scientist;Services;Students;success;symposium;Talents;Teacher Professional Development;Technology;Training;Training and Education;Translational Research;Universities;user-friendly;web-based tool;working group

PROJECT_TITLE: Center for Biomedical Research Excellence, Epigenomics of Development and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-4 (C3)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

PROJECT_TERMS: Accountability;Advisory Committees;Applications Grants;Area;Artificial Intelligence;Bioinformatics;Biometry;Budgets;career;Centers of Research Excellence;Clinical;Collaborations;Communities;Computational Biology;Core Facility;Development;Disease;Education;Educational workshop;Ensure;Epigenetic Process;epigenomics;equity, diversity, and inclusion;Evaluation;experience;Faculty;faculty support;FarGo;Fee-for-Service Plans;Feedback;Financial Support;Fostering;Funding;Future;Genomics;Goals;Grant;Group Meetings;Growth;Human Resources;improved;Individual;Infrastructure;innovation;Institution;International;Medical center;meetings;member;Mentors;Mentorship;mid-career faculty;North Dakota;novel;operation;Organization and Administration;Outcome;Participant;Pilot Projects;Procedures;programs;Publications;recruit;Research;Research Personnel;Resources;Science;Secure;Series;Services;Structure;student mentoring;success;symposium;Technology;Training;Training Activity;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

PI_NAMEs: PARRELLO, DAMIEN  (contact)

PROJECT_TERMS: Adopted;Area;base;Big Data;Bioinformatics;bioinformatics pipeline;Biological Assay;Biomedical Research;Budgets;Cells;Centers of Research Excellence;Charge;Cleavage Under Targets and Release Using Nuclease;cloud based;Code;Collaborations;Communities;cost;cost effective;Cost efficiency;Data;Data Analyses;data analysis pipeline;Dedications;Dependence;Development;Disease;Dryness;Educational workshop;empowerment;Ensure;Epigenetic Process;epigenomics;experience;Extramural Activities;Fostering;Foundations;Funding;Genomics;Growth;High-Throughput Nucleotide Sequencing;Human Resources;improved;Income;Industry;industry partner;Institution;interdisciplinary collaboration;Knowledge;Laboratories;Link;Mission;nano-string;nanopore;new technology;next generation sequencing;North Dakota;operation;Peer Review;Phase;Pilot Projects;Precision Run-On Sequencing;Preparation;Price;Principal Investigator;programs;Provider;Publications;recruit;Research;research and development;Research Personnel;Research Support;Resources;Running;Sampling;Services;Source;Specimen;Structure;success;System;Technology;Time;Training;transcriptome sequencing;transcriptomics;Trust;Universities;user-friendly;Wages;working group

PROJECT_TITLE: Genomics Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Immunization;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: GLASSBORO

ORG_DEPT: CHEMISTRY

ORG_NAME: ROWAN UNIVERSITY

PHR: Project Narrative This project focuses on the development of a liquid chromatography-mass spectrometry platform with microfluidic sample preparation for sensor-like, real-time analysis of complex biological systems. The technique will be used to characterize transient chemical signaling in organoid models of traumatic brain injury and bacterial biofilm formation, as well as monitor the production process of antibody-based therapeutic agents.

PI_NAMEs: GRINIAS, JAMES P (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: analytical tool;Antibody Therapy;biological systems;Blood capillaries;Cell Culture Techniques;Cell model;Chemicals;Chlorides;complex biological systems;Culture Media;Derivation procedure;Detection;Development;Devices;improved;Injections;liquid chromatography mass spectrometry;manufacture;Measurement;Methods;Microbial Biofilms;Microfluidics;Miniaturization;Modeling;Monitor;neurotransmitter release;Nutrient Depletion;Organoids;Performance;Polyamines;Preparation;Process;Production;programs;Research;Sampling;Science;sensor;Signal Transduction;small molecule;System;Systems Analysis;Techniques;temporal measurement;Therapeutic Agents;Therapeutic antibodies;Time;Traumatic Brain Injury

PROJECT_TITLE: Sensor-Like LC-MS Platform for Rapid Online Monitoring of Metabolites in Biological Systems

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_CITY: SIOUX FALLS

ORG_NAME: SANFORD RESEARCH/USD

ORG_STATE: SD

PHR: OVERALL PROJECT NARRATIVE We will continue to develop a multidisciplinary research center focused on understanding and treating childhood diseases. The Center will sustain its supportive environment for scientists investigating the basis of and approaches to treat pediatric disease, specifically through high quality research Cores and sustained training and mentorship. Additionally, through careful and continual evaluation the Center will ensure its Cores and investigators are set up for success and self-sustainability post COBRE.

PI_NAMEs: ROUX, KYLE J (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Advisory Committees;Applications Grants;Applied Genetics;Basic Science;Biochemical;Biochemistry;Bioinformatics;career;Cell Physiology;Cell Proliferation;Cells;Centers of Research Excellence;Cessation of life;Child;Child Health;Child health care;Childhood;Clinic;Clinical;collaborative environment;Communities;Complement;Data;Development;Developmental Process;Diagnosis;Disease;Educational workshop;Effectiveness;empowerment;Ensure;Environment;Evaluation;experience;faculty research;fetal programming;Fostering;Foundations;functional genomics;Funding;Genetic Diseases;Goals;Growth;Growth and Development function;Health;Healthcare Systems;Human Biology;Human Development;human disease;improved;innovation;Institution;Interdisciplinary Study;Label;Leadership;Learning;Medicine;member;Mentors;Mentorship;Methods;migration;model organism;Modeling;Molecular;Molecular Biology;Morphogenesis;multidisciplinary;Neurosciences;Northern Plains;Pediatric Hospitals;Pediatric Research;Phase;Physicians;Pilot Projects;pressure;programs;protein function;Proteins;Proteome;Publications;recruit;Research;Research Activity;Research Personnel;Research Support;Resource Sharing;Resources;Rural;Scientist;Series;Services;single cell sequencing;Sioux Falls;South Dakota;success;supportive environment;symposium;Technical Expertise;Training;Translational Research;translational scientist;translational study;United States;United States National Institutes of Health

PROJECT_TITLE: Center for Pediatric Research


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Pediatric;Prevention

PROJECT_TERMS: Advisory Committees;Animal Model;Applications Grants;Biochemistry;Biomedical Research;Capital;career;Cellular biology;Centers of Research Excellence;Chalk;Child Health;Child health care;Childhood;Clinical;Clinical Research;Core Facility;Data;Development;Developmental Biology;Diagnosis;Disease;Ensure;Environment;Equipment;Evaluation;Fostering;Foundations;Future;Genetic;Goals;graduate student;Growth;Health;Human Biology;Human Development;human disease;improved;innovation;insight;Institution;Laboratory Research;Learning;Measures;medical schools;member;Mentors;Mentorship;Mission;Modeling;Molecular Biology;Monitor;multidisciplinary;Neurosciences;next generation;Participant;pediatric department;Pediatric Research;Phase;Pilot Projects;post-doctoral training;postgraduate education;Prevention;Process;Program Evaluation;programs;Publications;Quality of life;Recommendation;Research;Research Activity;Research Personnel;Resource Sharing;Resources;Rest;Science;Scientist;South Dakota;success;symposium;synergism;Technical Expertise;Therapeutic;tool;Training;Training and Education;Translating;Translational Research;translational study;Universities;Wit


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Pediatric

PROJECT_TERMS: Affinity;Biochemistry;Biotin;Biotinylation;Cells;Centers of Research Excellence;Childhood;Chimeric Proteins;comparative;Consult;Consultations;Data Analyses;design;Detection;Disease;Equipment;experience;Experimental Designs;experimental study;Faculty;Fees;Funding;Goals;Health;Human Resources;innovative technologies;Institution;Label;Ligase;Manuscripts;Mass Spectrum Analysis;member;Methods;Mission;Mutation;novel;novel strategies;Pediatric Research;Phase;Plasmids;Preparation;protein protein interaction;Proteins;Proteomics;Protocols documentation;Recording of previous events;repository;Research;Research Personnel;Research Project Grants;Rest;Sampling;Scientist;screening;Services;Time;Training;Validation;Work

PROJECT_TITLE: Biochemistry Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Pediatric

PI_NAMEs: SURENDRAN, KAMESWARAN  (contact)

PROJECT_TERMS: Address;analysis pipeline;Applications Grants;ATAC-seq;Bioinformatics;Biological;Biological Assay;Biomedical Research;cell growth regulation;Cell Physiology;Cells;Centers of Research Excellence;Childhood;ChIP-seq;chromatin immunoprecipitation;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Consultations;Core Facility;Custom;Data Analyses;data management;Data Set;design;Development;Disease;DNA;Ensure;Environment;epigenetic variation;epigenome;Equipment;Eukaryotic Cell;exome sequencing;Experimental Designs;Fee-for-Service Plans;functional genomics;Funding;Gene Expression;Gene Expression Profiling;Genetic;Genetic Variation;Genome;genome editing;Genome engineering;Genomics;Goals;graduate student;Growth;Guide RNA;High Performance Computing;High-Throughput Nucleotide Sequencing;Histology;Image;In Situ Hybridization;Informatics;Infrastructure;Institution;interest;Investigation;Investigator-Initiated Research;Laboratories;Learning;Libraries;Malignant Neoplasms;Manuscripts;Mediating;Medical;member;microbial;Molecular;Molecular Biology;novel strategies;nuclease;Nucleic Acids;operation;Organism;Pathway Analysis;Pattern;Pediatric Research;Performance;Phase;preclinical study;Preparation;Principal Investigator;programs;Protocols documentation;Provider;Publications;Research;Research Personnel;Research Support;Resource Sharing;RNA;RNA analysis;Sampling;Scientist;Services;single cell genomics;single-cell RNA sequencing;South Dakota;Structure;student training;System;Techniques;Technology;Time;Tissues;Training;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Universities;Variant;Writing

PROJECT_TITLE: Functional Genomics and Bioinformatics Core


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Obesity

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: RELEVANCE TO PUBLIC HEALTH The goal of the proposed research is to develop ground-breaking targeted digital twin strategy for non-invasive guidance of optimal ablation therapy for ventricular arrhythmias in patients with ischemic cardiomyopathy based on uncovered new insights regarding the arrhythmogenic potential of penetrating adipose tissue in the zone of infarct. The project will utilize the combination of imaging, personalized computational modeling (digital twins), experimental and clinical measurements, and machine learning. Successful execution of the proposed studies will provide new mechanistic understanding of the role of penetrating adiposity in promoting and sustaining ventricular arrhythmias, and will lead to significant improvements in determining the critical ventricular tachycardia circuits that are the targets of ablation.

PI_NAMEs: TRAYANOVA, NATALIA A. (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: 3-Dimensional;Ablation;Accounting;Adipose tissue;Anti-Arrhythmia Agents;Arrhythmia;Artificial Intelligence;cardiac magnetic resonance imaging;Cardiovascular system;Cells;Cicatrix;Clinical;Clinical Data;Clinical Research;clinical translation;Clinical Trials;Complex;Computer Models;Data;Development;digital twin;Disease;Drug or chemical Tissue Distribution;economic impact;Electrophysiology (science);Environment;experimental study;Feasibility Studies;Fibrosis;Foundations;Gadolinium;Health Care Costs;health goals;Heart;heart rhythm;Human;Image;imaging capabilities;improved;Infarction;Infiltration;insight;ischemic cardiomyopathy;Knowledge;Location;Machine Learning;Maps;Measurement;Medical;mortality;Myocardial Infarction;Myocardium;Nature;novel;Obesity;Patients;Penetration;Procedures;Property;Public Health;Publishing;Recurrence;Research;Role;Scanning;Site;stem;sudden cardiac death;Technology;technology development;Testing;Tissues;tool;treatment optimization;Twin Multiple Birth;Ventricular;Ventricular Arrhythmia;Ventricular Tachycardia;Visualization;Work

PROJECT_TITLE: Heart Digital Twin Analysis of Arrhythmias due to Infiltrating Adiposity

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: DURHAM

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Black or African American professionals account for no more than 3% of the workforce in the fields of Otolaryngology and Communication Sciences. The Duke Black or African-American research training Pathway to Otolaryngology and Communication Sciences (BAA-POCS) program seeks to address this career disparity by engaging undergraduate students from two Historically Black Colleges and Universities in North Carolina for a robust mentored research training curriculum, augmented by comprehensive clinical observation, in which they will gain exposure to different subspecialties in Otolaryngology and Communication Sciences.

PI_NAMEs: FRANCIS, HOWARD W;FRANK-ITO, DENNIS ONYEKA (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Address;Affect;African American;African American population;African American student;aluminum sulfate;Association of American Medical Colleges;Awareness;Basic Science;Black American;black patient;Black Populations;Black race;care outcomes;career;Career Choice;Caring;Child;Clinical;clinical care;Clinical Research;Clinical Sciences;clinical training;cohort;college;Communication;Community Health;Complex;cultural competence;Development;Development Plans;Disease;Disparity;distrust;Education;education resources;Educational Curriculum;Ensure;experience;Exposure to;Face;Faculty;Goals;graduate school;graduate school preparation;Head and Neck Surgery;health inequalities;Historically Black Colleges and Universities;improved;interest;learning strategy;Life;medical schools;member;Mental Health;Mentors;Mentorship;multi-racial;North Carolina;Otolaryngology;Outcome;Pathway interactions;Patients;peer;peer support;physical conditioning;Process;programs;Provider;public health relevance;Race;recruit;Reporting;Research;research study;Research Training;role model;Saints;Science;Self Care;Self Efficacy;Social support;socioeconomic disparity;STEM field;student participation;Students;Support Groups;Thinness;Training;undergraduate student;underrepresented minority student;Universities;Writing

PROJECT_TITLE: Developing a Pathway for Preparing Underrepresented Minority Students for a Career in Otolaryngology and Communication Sciences

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Z (43)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Infertility

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE The project narrative is as originally proposed.

PI_NAMEs: BELL, SUZANNE O'DEA (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TITLE: Advancing Understanding and Measurement of Infertility, Related Fears and Stigma, and Associated Consequences in Low-Resource Countries


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation

ORG_DEPT: OPHTHALMOLOGY

PHR: Project Narrative Vision impairment reduces the effectiveness with which vision can be used to travel safely and pursue intended activities at home and in public spaces. Evaluating and enhancing the visual accessibility of environments supports the highest level of independence for people with vision impairment before relying on assistive technology or human assistance. Using computer vision algorithms and sensing technology, this research aims to develop an objective tool to complement the current observational practice in visual environmental evaluation.

PI_NAMEs: XIONG, YINGZI  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Address;algorithm development;Algorithms;Architecture;Awareness;base;built environment;Caregivers;Cellular Phone;Clinic;Clinical;Complement;Complex;Computational algorithm;Computer Models;Computer software;Computer Vision Systems;Computers;Conscious;Consensus;Contrast Sensitivity;cost effective;Databases;design;Detection;Development;digital;Disorientation;Effectiveness;efficacy evaluation;Engineering;Environment;Evaluation;experience;Eye;falls;Feedback;Foundations;General Population;head mounted display;high risk;Home;Home environment;Human;Image;improved;Individual;Laboratories;Light;Lighting;Maps;Measures;Methods;Mind;Modeling;Modification;novel;Participant;Patients;Persons;Phase;physically handicapped;Privatization;Protocols documentation;Reading;Reporting;Research;Research Methodology;Resolution;Safety;Sampling;Self-Help Devices;sensor;sensor technology;Services;smartphone application;Specialist;Specific qualifier value;technology development;telehealth;Testing;tool;Travel;user-friendly;Validation;Vision;vision development;vision rehabilitation;Vision research;Visual;Visual Acuity;Visual impairment;Visualization

PROJECT_TITLE: Enhancing Visual Accessibility of Indoor Spaces

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Social Determinants of Health;Telehealth

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: PROJECT NARRATIVE Individuals living with likely incurable cancer need feasible, accessible evidence-based depression treatment options. To address this need, we propose a Hybrid Type I effectiveness-implementation trial to: 1) comprehensively assess the effectiveness of a proactive identification (ID) + digital mental health intervention (DMHI) approach among individuals living with likely incurable cancer, 2) gather information on intervention (proactive ID + DMHI) delivery to guide best practices for implementation, and 3) develop an Electronic Health Record-derived phenotype of likely incurable cancer to enhance ID of individuals living with likely incurable cancer. This program of research has the potential to expand evidence-based psychosocial treatment access in a manner that is scalable across oncology settings and will enhance scientific knowledge for improving comprehensive survivorship care for individuals living with likely incurable cancer.

PI_NAMEs: DAHNE, JENNIFER RENEE (contact);GRABOYES, EVAN MICHAEL

PROGRAM_OFFICER_NAME: ETON, DAVID T

PROJECT_TERMS: 2 arm randomized control trial;acceptability and feasibility;Accreditation;Address;Adherence;Adoption;Anxiety;Behavioral;Cancer Center;Cancer Survivor;cancer therapy;care delivery;care providers;Caring;Cessation of life;Chronic;Clinical;clinically relevant;clinically significant;Consolidated Framework for Implementation Research;Data;deep learning;Depression screen;depressive symptoms;Development;digital mental health;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Electronic Health Record;electronic structure;Eligibility Determination;Enrollment;Ensure;Evaluation;evidence base;Feedback;Feeling suicidal;Future;future implementation;Goals;Health Personnel;Health Services Accessibility;Hybrids;implementation determinants;implementation evaluation;implementation facilitators;implementation outcomes;improved;Individual;information gathering;Infrastructure;Intervention;intervention delivery;Knowledge;Laboratories;Link;Malignant Neoplasms;Manuals;Mental Depression;Mental Health;Meta-Analysis;Methods;Modeling;Morbidity - disease rate;Natural Language Processing;Oncology;Outcome;Palliative Care;Pathology Report;patient population;Patients;Phase;Phenotype;pilot trial;Population;Proctor framework;prognostic;programs;Provider;psychosocial;Psychosocial Assessment and Care;psychosocial outcome;Quality of life;Radiology Specialty;Randomized;Recurrent disease;Reporting;Research;Research Design;screening;secondary outcome;Service delivery model;Services;Shoulder;social stigma;Structure;suicidal;Supportive care;Survivors;survivorship;System;targeted delivery;Testing;Therapeutic Trials;Training;Transportation;treatment as usual;Uncertainty;usability;Work

PROJECT_TITLE: Evaluation of a Proactive Identification and Digital Mental Health Intervention Approach to Address Unmet Psychosocial Needs of Individuals Living with Likely Incurable Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (M1)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: COLUMBIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

PHR: The Center for Targeted Therapeutics (CTT) at the University of South Carolina (USC) brings together junior and senior faculty with a common interest in the discovery of new molecular targets and prototype targeted drugs for the treatment of different diseases. The CTT has been instrumental in creating and supporting the critical mass of Targeted Therapeutics researchers at USC and the research resource cores required for their studies. During Phase 3, the CTT will work to assure continued growth of Targeted Therapeutics research at USC and the sustainability of the resource cores that are critical for this research.

PI_NAMEs: KIARIS, HIPPOKRATIS  (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Address;Applications Grants;Area;Award;Bioinformatics;Biomedical Research;career networking;Cellular biology;Centers of Research Excellence;Charge;Clinical;Clinical Trials;Collaborations;college;Communities;Core Facility;COVID-19 pandemic;COVID-19 testing;COVID-19 therapeutics;design;Development;Disease;drug candidate;Drug Combinations;Drug Delivery Systems;Drug Design;drug discovery;drug synthesis;Drug Targeting;Economic Development;Education;Educational workshop;Endowment;Environment;Equipment;Faculty;Financial Support;Flow Cytometry;functional genomics;Funding;Future;Genetic;Genomics;Goals;Grant;Growth;Immunology;Individual;Institution;instrumentation;interest;Investigational Therapies;Leadership;Legal patent;Medical center;medical specialties;meetings;member;Mentors;Mentorship;Methodology;Methods;Microscopy;mid-career faculty;Mission;Molecular Biology;Molecular Target;novel;operation;pandemic disease;Pathology;Pathway interactions;Pharmaceutical Chemistry;Phase;Philosophy;Physiology;Pilot Projects;Productivity;Program Research Project Grants;Program Sustainability;programs;Protein Biochemistry;Proteins;prototype;Public Health;Publishing;recruit;Request for Proposals;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;senior faculty;Senior Scientist;Services;Small Business Innovation Research Grant;Small Business Technology Transfer Research;South Carolina;Structure;sustainable resource;Talents;targeted treatment;Testing;Therapeutic Research;Training;undergraduate education;Underserved Population;United States National Institutes of Health;Universities;Validation;Work

PROJECT_TITLE: Center for Targeted Therapeutics


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Acceleration;Advisory Committees;Applications Grants;Area;career development;Centers of Research Excellence;Collaborations;Communication;Communities;Data;Development;diversity and inclusion;Environment;Evaluation;Faculty;Feedback;Fostering;Funding;Future;Generations;Grant;Growth;Individual;Institution;Internet;Leadership;Manuscripts;Mediating;meetings;member;Monitor;National Institute of General Medical Sciences;operation;Outcome;Phase;Pilot Projects;Process;Productivity;programs;Progress Reports;Recommendation;recruit;Reporting;Research;Research Personnel;Research Project Grants;Scientist;senior faculty;Series;Small Business Innovation Research Grant;Small Business Technology Transfer Research;South Carolina;Structure;success;symposium;targeted treatment;Therapeutic Research;United States National Institutes of Health;Universities;University adminstration;Work

PROJECT_TITLE: Admin-Core


PI_NAMEs: SHTUTMAN, MICHAEL  (contact)

PROJECT_TERMS: Acceleration;Affect;Area;Bioinformatics;Cell Line;Centers of Research Excellence;epigenomics;experience;functional genomics;Gene Expression;Generations;Genetic;Genomic approach;Genomics;Goals;Image;Institution;interest;investigator training;Laboratories;Leadership;lentivirally transduced;Measurement;Mentors;Methodology;Mission;Modernization;Modification;Molecular Genetics;multidisciplinary;Mycoplasma;new therapeutic target;next generation;next generation sequencing;Phase;Phenotype;Pilot Projects;programs;Proteins;Research;Research Personnel;Research Project Grants;Research Support;Scientist;Services;skills;South Carolina;targeted treatment;Techniques;Technology;Testing;Time;transcriptomics;Universities;Validation;vector;Western Blotting

PROJECT_TITLE: Functional Genomics Core


PI_NAMEs: MCINNES, CAMPBELL  (contact)

PROJECT_TERMS: analog;Biological;Centers of Research Excellence;chemical synthesis;Chemicals;Core Facility;design;Disease;Drug Design;drug development;drug discovery;drug synthesis;druggable target;Equipment;Evaluation;Faculty;Funding;interest;investigator training;Laboratories;Ligands;member;Methodology;Mission;Modality;novel;novel therapeutics;Outcome;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Research;Research Personnel;Services;Structure;success;targeted treatment;Techniques;Training

PROJECT_TITLE: Drug Design and Synthesis Core


PI_NAMEs: LIM, CHANG-UK  (contact)

PROJECT_TERMS: Affect;Antibodies;Cell Separation;Cells;Centers of Research Excellence;Chemicals;Data Analyses;Equipment;Experimental Designs;Faculty;flexibility;Flow Cytometry;Gene Modified;Genetic;Goals;In Vitro;in vivo;Infrastructure;interest;investigator training;live cell imaging;member;Methodology;Microscopy;Molecular Target;Phase;programs;Reagent;Research;Research Personnel;Research Project Grants;Services;small molecule;Sorting;South Carolina;success;targeted treatment;Techniques;Tissues;Universities

PROJECT_TITLE: Microscopy and Flow Cytometry Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative: Bacterial pathogens require specific adaptations to colonize their infectious niche including a subset of these pathogens, such as Listeria monocytogenes, have evolved to utilize the cytosol of mammalian cells as their replication niche. Through our previous genetic screens we have identified two critical pathways, cell wall stress responses and metabolic adaptations, required for L. monocytogenes to survive and thrive in the cytosol and to ultimately cause disease. Aim 1 of this proposal will characterize how L. monocytogenes responds to cell wall stress and in turn how the host imposes cell wall stress, while aim 2 will characterize L. monocytogenes metabolic adaptation to the cytosol and how altered bacterial metabolism impacts the host response to infection.

PI_NAMEs: SAUER, JOHN-DEMIAN  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acetates;adaptive immunity;Adjuvant;Anabolism;Antibiotics;antimicrobial;Bacteria;bacterial metabolism;biological adaptation to stress;Burkholderia;Carbon;Cell Wall;Cells;Cellular biology;Critical Pathways;Cytosol;Defect;Development;Disease;Environment;extracellular;foodborne pathogen;Francisella tularensis;Genes;Genetic Screening;Genetic Transcription;Glycerol;Goals;Hexoses;Host Defense;Human;human pathogen;Immune response;in vivo;Infection;inorganic phosphate;Intervention;Life;Listeria monocytogenes;Listeriosis;Livestock;Macrophage;Mammalian Cell;Metabolic;Metabolism;model organism;Mus;mutant;Natural Immunity;next generation;novel strategies;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Penicillin-Binding Proteins;Peptidoglycan;Phosphoproteins;Phosphorylation;Phosphotransferases;Production;Protein-Serine-Threonine Kinases;Pyruvate Dehydrogenase Complex;response;Rickettsia;Role;Series;Shigella;Shigella flexneri;Source;Stress;Testing;Virulence

PROJECT_TITLE: Identification and Characterization of Genes Required for Listeria monocytogenes Cytosolic Survival

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PSYCHOLOGY

PHR: Public Health Relevance Statement This study evaluates the efficacy of a cultural strengths-based family resilience intervention to promote health behavioral skills for improving physical activity, diet, and health-related outcomes (obesity, blood pressure) in overweight African American adolescents and their families.

PI_NAMEs: MARTIN, PAMELA P;WILSON, DAWN K (contact)

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: Academic achievement;acceptability and feasibility;Address;Adolescent;African American;Behavior;Behavioral;behavioral health;Black race;Blood Pressure;Body mass index;Buffers;Child Rearing;Chronic;Chronic Disease;cohesion;Communication;Control Groups;coping;Data;Diabetes Mellitus;Diet;dietary;Dietary intake;efficacy evaluation;efficacy testing;Elements;empowerment;Ethnic Origin;Exercise;experience;Family;Fatty acid glycerol esters;follow-up;Fostering;fruits and vegetables;Health;Health behavior;Health behavior and outcomes;Health behavior change;Health education;Health Promotion;healthy lifestyle;Heart Diseases;Heterogeneity;improved;Informal Social Control;Intake;Intervention;intervention effect;Light;Link;Maintenance;Mediating;Mediator;Mental Depression;Mental Health;Modeling;moderate-to-vigorous physical activity;Motivation;Obesity;Outcome;Overweight;Parents;perceived stress;Physical activity;post intervention;prevent;programs;protective factors;public health relevance;Race;racial discrimination;racial identity;racial population;Randomized, Controlled Trials;Research;resilience;Risk;Risk Taking;sedentary lifestyle;Self Efficacy;skills;social;social cognitive theory;Socialization;Spirituality;Stress;stress management;stress resilience;stressor;System;treatment effect;waist circumference;Weight;Well in self;Work;Youth

PROJECT_TITLE: Linking Exercise for Advancing Daily Stress (LEADS) Management and Resilience in Black Families

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Services;Mental Health;Mental Illness;Social Determinants of Health

ORG_CITY: Fort Lauderdale-Davie

ORG_NAME: NOVA SOUTHEASTERN UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative Weight stigma is pervasive and harmful; it contributes to poorer physical and mental health outcomes due to stress processes, lower quality care from healthcare providers, and avoidance of healthcare services by patients. Psychologists play a large role in behavioral health programs, as well as care for eating disorders, body dysmorphia, and other conditions that make it essential that they are able to effe ctively communicate with higher-weight people in a non-stigmatizing way. This research seeks to examine how weight stigma changes among students in doctoral clinical psychology programs and the mechanisms underlying the development of weight stigma over time to inform training activities to reduce weight stigma and increase the preparedness of future mental health professionals to provide high-quality care to patients of all sizes.

PI_NAMEs: BROCHU, PAULA  (contact)

PROJECT_TERMS: Accreditation;Address;Affect;Attitude;Awareness;Behavior;behavioral health;Belief;Body Image;Body mass index;Body Weight decreased;Caring;Clinical;Clinical Psychology;clinical training;Communication;Competence;Data;Development;Discipline;Eating Disorders;Enrollment;Environment;Event;experience;Fatty acid glycerol esters;Foundations;Funding;Future;Goals;Health;health care quality;health care service;health disparity;Health education;Health Personnel;Health Professional;Healthcare;Hispanic-serving Institution;improved;Influentials;insight;Intervention;Knowledge;Literature;longitudinal design;Measures;Mediating;Mediation;Medical;Medical Education;Medical Students;Mental disorders;Mental Health;Mental Health Services;Mentorship;Methods;modifiable risk;Morbidity - disease rate;mortality;novel;Outcome;patient oriented;Patients;Personal Satisfaction;Persons;physical conditioning;Play;poor health outcome;Prejudice;Process;programs;Prospective cohort;psychologic;Psychologist;Psychology;Quality of Care;Readiness;Reporting;Research;Research Project Grants;Risk;Risk Factors;Role;Secure;social;social group;social norm;Social Psychology;social stigma;Stereotyping;Stigmatization;Stress;student training;Students;success;Survey Methodology;Testing;theories;Time;Training;Training Activity;Training Programs;United States National Institutes of Health;Universities;Weight;Weight Gain

PROJECT_TITLE: Weight Stigma among Doctoral Clinical Psychology Students: Examining Change and Testing Underlying Mechanisms.

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-T (SB)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Nutrition;Precision Medicine

ORG_CITY: Prairie View

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PRAIRIE VIEW AGRI & MECH UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative This project aims to develop a virtual platform to computationally assess the pathogenesis scenario, diagnostic steps, and therapeutic procedures for excess glucose-related cardiovascular and gastrointestinal diseases at a relatively low cost and time. The project is relevant to public health because it focuses on developing a new and alternative strategy for addressing excess glucose concentration in the body, which is a major precursor to most gastrointestinal-cardiovascular diseases, including diabetes mellitus, obesity, cancers, and non-alcoholic fatty liver disease (NAFLD). Therefore, the proposed research is pertinent to one of the NIH's missions, which is to reduce illness and diseases.

PI_NAMEs: OLANREWAJU, KAZEEM  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: absorption;Address;Biochemical;Biological Availability;Biophysics;Blood Circulation;blood glucose regulation;Blood Vessels;Cardiovascular Diseases;Cardiovascular system;Cellulose;chemical reaction;Colorectal;comorbidity;computational platform;Consumption;cost;Coupled;design;Development;Diabetes Mellitus;Diagnostic;Diagnostic Procedure;Diet;dietary;Dietary Fiber;Dietary Sugars;Disease;Drug Metabolic Detoxication;Enzymes;epidemiology study;Equation;Etiology;experimental study;Fatty Acids;Fiber;Fibrates;flexibility;Fructose;gastrointestinal;Gastrointestinal Diseases;gastrointestinal system;Gastrointestinal tract structure;Glucose;glucose transport;glycogenesis;glycosylation;Goals;Healthcare;Hexoses;Homeostasis;human disease;Hydrolysis;in silico;In Vitro;in vivo;insight;Intake;interest;intestinal epithelium;Intestines;Investigational Therapies;Isomerism;Kinetics;laboratory experiment;lipid biosynthesis;Liver;liver metabolism;Malignant Neoplasms;Mathematics;Measures;Metabolic;metabolic rate;Metabolism;Mission;Modeling;non-alcoholic;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Nutrient;Nutritive Value;Obesity;Oligosaccharides;Oral Administration;Organ;outcome prediction;Outcomes Research;Pathogenesis;Pathologic;Peripheral;Physical condensation;Physics;Physiological;Polysaccharides;pressure;Process;Production;Public Health;Reaction;reaction rate;Reducing diet;Regulation;remediation;Research;Research Project Grants;Risk;Role;Route;Scheme;Series;Small Intestines;sugar;Supplementation;System;Temperature;Testing;Therapeutic;Therapeutic Effect;Therapeutic procedure;Time;Tissues;tool;treatment strategy;Unhealthy Diet;United States National Institutes of Health;Vascular blood supply;virtual;virtual laboratory;virtual platform;Water;Work

PROJECT_TITLE: Numerical Experimentation of the Therapeutic Effect of Excess Glucose Transglycosylation and Optimization in the Proximal Small Intestine.


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Aging

ORG_DEPT: GENETICS

PHR: Project Narrative The cells within many of our tissues, particularly the brain and muscles, maintain themselves for long periods of time without being replaced. This research will explore the intricate processes that enable cells to preserve their integrity and function post-developmentally. As deterioration of cellular maintenance contributes to numerous diseases as well as pathologies of aging, this research aims to pave the way for innovative treatments that reduce illness.

PI_NAMEs: RICHARDSON, CLAIRE ELISSA (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Acute;Address;Aging;Animals;Brain;Caenorhabditis elegans;Cell Maintenance;cell type;Cells;Cellular biology;Chronic;Deterioration;Development;Disease;Ensure;Exposure to;extracellular;fluorescence imaging;Foundations;Genetic;Genetic Screening;imaging capabilities;in vivo;innovation;Knowledge;life span;Lysosomes;Maintenance;Measures;Metabolic;Metabolic Diseases;Metabolism;Methods;Molecular;Muscle;Nematoda;Neurodegenerative Disorders;novel;Organelles;Organism;Pathology;Physiological;Pollution;Postdoctoral Fellow;preservation;Process;protein degradation;Proteins;Radiation;Research;Resolution;Signal Transduction;stressor;therapy design;Time;Tissues;tool;tool development

PROJECT_TITLE: Mechanisms of Cellular Maintenance

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ORG_CITY: RENO

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Project Narrative Cardiovascular disease is the leading cause of death worldwide, and the overactivity of the sympathetic nervous system (the “fight or flight” branch of the autonomic system) plays a key role in the pathogenesis or progression of numerous cardiovascular diseases. In this project we will use high-resolution, live-cell imaging techniques to visualize the changes that occur in sympathetic neurons during disease states. An increased understanding of the molecular underpinnings that are responsible for sympathetic neuron overactivity can help in earlier diagnosis and prevention of cardiovascular diseases, as well as enhance our ability to develop novel therapies.

PI_NAMEs: AKIN, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Address;Animal Model;Attention;Autonomic nervous system;Axon;Cardiac;Cardiac Myocytes;Cardiac Output;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular Models;Cardiovascular system;Cause of Death;Cells;Central Nervous System;Characteristics;Chemicals;chemotherapy;Coculture Techniques;Control Animal;Disease;Disease Progression;Early Diagnosis;Efferent Pathways;Exhibits;fighting;Fluorescence Microscopy;Foundations;Frequencies;Goals;Grant;Heart;Heart failure;Heart Rate;Homeostasis;Hyperactivity;hypertensive;Imaging Techniques;Inbred SHR Rats;Inflammation;innovation;insight;live cell imaging;live cell microscopy;Location;Measures;Microscopy;Molecular;Molecular Motors;Muscle Cells;Myocardial Infarction;Neonatal;nerve supply;neurogenic hypertension;Neurons;neuropeptide Y;Neuropeptides;Neurotransmitters;Nociceptors;Norepinephrine;novel;novel therapeutic intervention;novel therapeutics;Organ;Outcome;painful neuropathy;Pathogenesis;Pathologic;Pathology;Patient-Focused Outcomes;Pattern;Perfusion;Peripheral;Plasma;Play;potential biomarker;Preparation;Rattus;Regulation;Renal function;Reporting;Research;Research Personnel;Resolution;response;Risk;Sodium;Structure of superior cervical ganglion;sudden cardiac death;superresolution microscopy;Sympathetic Nervous System;Synapses;System;targeted treatment;Techniques;Testing;Therapeutic Intervention;Time;trafficking;Varicosity;vasoconstriction;Ventricular;Vesicle;Visualization;voltage

PROJECT_TITLE: Molecular mechanisms of sympatho-excitation in cardiovascular disease

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ORG_DEPT: PATHOLOGY

PHR: Project Narrative Inflammation is the underlying cause of a larger number of clinical disorders. Our Center will pursue multi- disciplinary research to study how compounds found in botanicals can suppress inflammation and identify new pathways that trigger or prevent inflammation by providing state-of-the-art research facilities to investigators.

PI_NAMEs: NAGARKATTI, MITZI ;NAGARKATTI, PRAKASH S (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Advisory Committees;Aging;Area;Attenuated;Autoimmune Diseases;autoimmune pathogenesis;Basic Science;Botanicals;Businesses;Cardiovascular Diseases;Cell Separation;Cells;Centers of Research Excellence;Chronic;chronic inflammatory disease;Clinical;college;Communicable Diseases;Complementary and alternative medicine;Core Facility;Data Analyses;dietary supplements;Disease;drug discovery;effective therapy;Epigenetic Process;epigenetic regulation;epigenomics;Equipment;expectation;Faculty;faculty research;Financial Support;Flow Cytometry;Funding;Goals;Grant;Hypersensitivity;Immunosuppressive Agents;Income;Individual;Infection;Inflammation;Inflammatory;innovation;Institution;Interdisciplinary Study;interest;International;Libraries;Malignant Neoplasms;medical schools;member;Mentors;microbiome;Mission;Modality;Monitor;multidisciplinary;Natural Compound;Natural Products;Nervous System Disorder;Neurodegenerative Disorders;novel;Obesity;Pathogenesis;Pathway interactions;Performance;Phase;Pilot Projects;Play;Predisposition;prevent;Productivity;programs;recruit;Regulation;Research;research facility;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Role;Scientist;Secure;single cell analysis;single-cell RNA sequencing;Source;South Carolina;success;Technology;tenure track;Toxic effect;Training;transcriptomics;United States Department of Veterans Affairs;United States National Institutes of Health;Universities

PROJECT_TITLE: Center for Dietary Supplements and Inflammation (CDSI) COBRE


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Dietary Supplements;Nutrition

PI_NAMEs: NAGARKATTI, PRAKASH S (contact)

PROJECT_TERMS: Advisory Committees;Area;Arts;Attention;Award;base;Businesses;Centers of Research Excellence;Collaborations;collaborative environment;college;Core Facility;data management;data sharing;Development;dietary supplements;Disease;drug discovery;Engineering;Ensure;Equipment;expectation;Extramural Activities;Faculty;faculty research;Fostering;Funding;Goals;Grant;Guidelines;human subject protection;Individual;Inflammation;Inflammatory;innovation;Institution;Intellectual Property;Interdisciplinary Study;interest;International;Journals;Leadership;medical schools;meetings;multidisciplinary;Nature;Phase;Pilot Projects;Positioning Attribute;Program Development;Program Research Project Grants;programs;Public Health Schools;recruit;Reporting;Research;Research Activity;research facility;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Science;scientific organization;Secure;senior faculty;Small Business Innovation Research Grant;Small Business Technology Transfer Research;South Carolina;Strategic Planning;success;Technology;Training;Underrepresented Minority;United States National Institutes of Health;Universities;Update;Vertebrates;Woman;Work


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Complementary and Integrative Health;Dietary Supplements;Genetics;Human Genome;Microbiome;Natural Products;Nutrition;Prevention

PI_NAMEs: YANG, XIAOMING  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;analytical tool;antagonist;Anti-Inflammatory Agents;Area;Aryl Hydrocarbon Receptor;ATAC-seq;Big Data;Binding;Biochemical;Bioinformatics;bioinformatics tool;Biological Assay;biomarker identification;Botanicals;cannabinoid receptor;Centers of Research Excellence;Chinese Herbs;ChIP-seq;Chromatin;Complex Analysis;cost effective;Data;Data Analyses;data quality;design;Development;Diagnosis;dietary supplements;Disease;DNA;DNA Methylation;drug discovery;Ensure;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Equipment;Faculty;FOXP3 gene;Funding;Future;Gene Expression;Generations;Genes;Genetic Transcription;Genome;genome-wide;Genomics;Goals;Grant;gut dysbiosis;histone modification;Hypermethylation;Immune response;immunoregulation;in silico;Individual;Inflammation;Inflammatory;inhibitor;innovation;insight;Institution;instrumentation;interest;Laboratories;Libraries;Ligands;Messenger RNA;Methods;microbial;microbiome;microbiome analysis;microbiome research;MicroRNAs;Mission;Molecular Conformation;molecular dynamics;mRNA Expression;National Center for Complementary and Integrative Health;Natural Compound;Natural Products;Nature;next generation sequencing;novel;novel strategies;novel therapeutics;Pathway Analysis;Performance;Phase;physical property;Pilot Projects;Plant Extracts;Plants;Play;Preparation;Prevention approach;Procedures;Prognosis;Program Research Project Grants;programs;Property;Publishing;Quality Control;receptor;receptor-mediated signaling;Regulation;Reproducibility;Research;research facility;Research Personnel;Research Project Grants;Resource Sharing;Ribosomal RNA;Sampling;screening;Secure;sequencing platform;Services;Shotgun Sequencing;Signal Pathway;single-cell RNA sequencing;Specificity;Standardization;Structure;Technology;tool;transcriptome sequencing;transcriptomics;Transplantation;United States National Institutes of Health;Untranslated RNA;Validation;Volatile Fatty Acids

PROJECT_TITLE: Bioanalytical Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Genetics;Human Genome;Natural Products;Nutrition;Prevention

PI_NAMEs: SINGH, NARENDRA P (contact)

PROJECT_TERMS: Acute;Adoptive Transfer;Affect;Aftercare;Apoptosis;Area;ATAC-seq;Biological Assay;Botanicals;cell determination;Cell Proliferation;Cell Separation;cell type;Cells;Centers of Research Excellence;Colitis;Colon;Colon Carcinoma;Colonoscopy;Color;Complex;Computer software;Core Facility;cytokine;Data;Data Analyses;Dedications;detector;dietary supplements;Educational workshop;Endoscopy;Equipment;equipment acquisition;Event;experience;Experimental Designs;Faculty;Familiarity;Flow Cytometry;fluorescence activated cell sorter device;Fluorescent Probes;Gene Expression;Genes;Genetic Transcription;Goals;high throughput technology;Human Resources;Image;Immune;immune cell infiltrate;Immunologics;in vivo;Individual;Inflammation;innovation;instrumentation;Lasers;Libraries;Measurement;medical schools;Microscopy;Mus;Neighborhoods;Nuclear;operation;Organ;Pattern;Performance;Phase;Phenotype;Pilot Projects;Play;Plethysmography;Population;Program Sustainability;Property;Proteins;pulmonary function;Pulmonary Inflammation;Reproducibility;Research;research facility;Research Personnel;Research Project Grants;Research Support;Resources;Running;Services;Signaling Molecule;single-cell RNA sequencing;Sorting;Suspensions;Technical Expertise;Techniques;Technology;Tissue Sample;Tissues;Training;transcription factor;transcriptomics;Transfection;Update

PROJECT_TITLE: Flow Cytometry and Cell Analysis Core


ED_INST_TYPE: PRIMATE CENTERS

NIH_SPENDING_CATS: Contraception/Reproduction;Hypertension;Infertility;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: PORTLAND

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Significant differences in the local placental renin-angiotensin system (RAS) have been implicated in adverse maternal and fetal outcomes. Using both mouse and rhesus macaque models, this project will determine how the RAS at the cell-specific level affects placental development. Understanding how abnormal placentation occurs, is important because proper formation and function of the placenta is critical to the survival and long- term health of babies, as well as the health of the pregnant person.

PI_NAMEs: VROOMAN, LISA ANNE (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Abnormal placentation;ACE2;Address;adverse pregnancy outcome;Affect;Alleles;angiogenesis;angiotensin I (1-7);Angiotensin II;Animals;Binding;Biological Process;Biology;blastocyst;Blood Flow Velocity;Blood Pressure;blood pressure elevation;Blood Pressure Monitors;blood pressure regulation;Cells;Circulation;Decidua;Development;disease model;Economic Burden;Embryo;Embryo Loss;Embryo Transfer;Endothelial Cells;Enzyme-Linked Immunosorbent Assay;Enzymes;Equilibrium;Exhibits;experimental group;experimental study;fetal;Fetal Development;Fetal Growth;Fetal Growth Retardation;Fetal health;Fetal Reduction;Fetal Weight;Fetus;Future;Gene Expression;Growth;Health;Histologic;Histology;Human;human model;Hypoxia;Immunohistochemistry;Impairment;improved;in vivo;Individual;Inflammation;innovation;Investigation;Kidney;Knock-out;Knowledge;Ligands;loss of function;Macaca mulatta;Mass Spectrum Analysis;Maternal Health;maternal outcome;Maternal-Fetal Exchange;Maternal-fetal medicine;Membrane;Methods;model building;Modeling;Monitor;Morphology;mouse model;Mus;novel;Organ;Outcome;Oxidative Stress;Pathway interactions;Pattern;perinatal outcomes;Persons;Phenotype;Physiological;Placenta;Placentation;Play;Pre-Eclampsia;Pre-implantation Embryo Development;preclinical study;Preclinical Testing;Pregnancy;Pregnancy Complications;Pregnancy loss;Pregnancy Outcome;pregnant;Proliferating;Protein Analysis;Proteins;psychologic;receptor;Renin-Angiotensin System;Research Proposals;Role;SARS-CoV-2 infection;Serum;Shapes;Signal Transduction;Source;Techniques;Testing;Time;Tissues;Transgenic Mice;trophoblast;Umbilical Blood;Uterus;vasoconstriction;Wild Type Mouse

PROJECT_TITLE: Investigation of the renin-angiotensin system at the maternal-fetal interface.

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Public Health Narrative: Poor care quality and safety in long-term care (LTC) facilities (i.e., nursing homes, assisted living)—particularly for persons living with dementia (PLWD)—leads to adverse events and increased mortality. Decision-support technologies (DS tech) have been proven to increase safety/quality of care and decrease staff burnout in acute and primary care settings. However, to date, DS tech has not been tailored in context- and workflow-specific ways to LTCs. This innovative study aims to improve quality of work (for staff) and quality/safety of care by implementing context- and workflow-specific DS tech in LTCs.

PI_NAMEs: OZKAYNAK, MUSTAFA  (contact)

PROGRAM_OFFICER_NAME: GRIPIOTIS, EROFILE

PROJECT_TITLE: Implementing decision support for long term care

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Rehabilitation

ORG_CITY: PHILADELPHIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: There is a significant difference in clinical competencies for treating voice between speech-language pathologists (SLPs) at expert pediatric voice centers and SLPs at other practice locations; this will disproportionately impact children with voice disorders who cannot afford to travel to specialty clinics. The proposed research is a necessary foundation to address this critical issue. Outcomes will establish the key themes that characterize expert voice therapy, including communication style, structure of the therapy sessions based on clinical decision-making, and implementation of therapy tools, with the ultimate goal of translating this knowledge of clinical expertise to SLPs in all practice locations.

PI_NAMEs: HELLER MURRAY, ELIZABETH SALMON (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Address;Affect;Affective;Area;Attitude;Auditory;Boston;career;Child;Childhood;Client;Clinic;Clinical;Clinical Competence;clinical decision-making;clinical practice;Communication;Communication Methods;communication theory;Competence;Country;Data;Dedications;design;Diagnosis;Disadvantaged;Discrimination;Disparate;Dysphonia;early-career faculty;Education;Educational process of instructing;Emotional;Environment;Evidence based practice;Family;Foundations;Frequencies;Goals;Health;health equity;health equity promotion;improved;innovation;Intelligence;interest;Interview;Knowledge;Language;Laughter;Left;Location;Medical center;medical specialties;Methodology;Methods;National Institute on Deafness and Other Communication Disorders;Nodule;novel;Outcome;Pain;Pathologist;Patient Self-Report;Pediatric Hospitals;peer;Perception;Personal Communication;Personality Traits;Phase;Population;programs;Qualitative Research;Reduce health disparities;Research;respiratory;Sampling;Schools;Scientific Advances and Accomplishments;skills;social;Speech;Speech Disorders;Speech Therapy;standard care;Structure;System;Taxonomy;theories;therapy outcome;tool;Training Programs;Translating;Travel;United States National Institutes of Health;Universities;Video Recording;Videotape;vocal cord;Voice;Voice Disorders;voice therapy;Work

PROJECT_TITLE: A Mixed Methods Analysis of Pediatric Voice Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-H (02)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Atherosclerosis;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Heart Disease;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative With longevity setting them apart from other primate species, humans experience high rates of cardiovascular, cerebrovascular, and neurodegenerative diseases during aging. Older great apes also exhibit cerebrovascular abnormalities, neurodegeneration with Alzheimer’s disease-like pathology, and frequent mortality from heart disease, but lack atherosclerosis and neurotoxicity that are devastating to humans. The goal of the proposed studies is to examine the interrelationship between age-related changes in cardiovascular and cerebrovascular disease in humans and great apes as a means of understanding their impact on longevity and health as well as the unique susceptibility of humans to cognitive decline.

PI_NAMEs: EDLER, MELISSA K.;HOF, PATRICK R (contact);RAGHANTI, MARY ANN ;SHERWOOD, CHESTER

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Affect;Age;age effect;age related;age related changes;Age-associated memory impairment;age-related disease;Aging;aging related disease;Alleles;Alzheimer like pathology;Alzheimer's Disease;Apolipoprotein E;Atherosclerosis;Atrophic;Autopsy;Biological Markers;biomarker development;biomarker identification;Blood Vessels;Brain;brain health;Brain scan;Cancer Center;Cardiomyopathies;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;CD36 gene;Cell Density;cell type;Cells;Cerebral Amyloid Angiopathy;cerebrovascular;Cerebrovascular Disorders;cerebrovascular pathology;Cerebrum;Chest;Cholesterol;Cognition;Cognitive;cognitive ability;cognitive change;Cognitive deficits;cognitive function;cognitive testing;comparative;Complement 3;Coronary Arteriosclerosis;Data;density;Diagnosis;Disease;Disease Progression;Echocardiography;Elderly;Electron Microscopy;Enzyme-Linked Immunosorbent Assay;Exhibits;experience;Fibrosis;Freezing;Functional disorder;Funding;Gene Expression;Gene Frequency;Goals;Gorilla gorilla;Grant;Health;Heart;Heart Diseases;Heart failure;Hematology;High Density Lipoproteins;Human;Image;Immunofluorescence Immunologic;Immunohistochemistry;Impaired cognition;improved;in vivo;Individual;insight;interstitial;Knowledge;Left Ventricular Hypertrophy;Length;Lesion;life span;lipid metabolism;Longevity;Low-Density Lipoproteins;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Medicine;Mitochondria;Monitor;Morphology;mortality;Motor;MRI Scans;Neopterin;Nerve Degeneration;Nervous System Trauma;Neurodegenerative Disorders;Neuroglia;neuroimaging;neuroinflammation;Neurologic;Neurons;neuropathology;neurotoxicity;neurovascular;Outcome;Pan Genus;Pan paniscus;Pathology;Pongidae;Pongo pygmaeus;Population;Positioning Attribute;potential biomarker;PPAR gamma;Predisposition;Primates;prospective;protein expression;Proteins;Research;research facility;Serum;Severities;species difference;Synapses;targeted treatment;Therapeutic Intervention;United States National Institutes of Health;Vascular Diseases;vascular risk factor;white matter;White Matter Hyperintensity

PROJECT_TITLE: Lifespan and Cardiovascular Health Effects on The Brain in Humans and Great Ape

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (M1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: Project Narrative Sensory systems play a critical role in human health, serving as the primary interface with the environment. This proposal aims to investigate how congenital visual impairments lead to compensations in other sensory systems, providing insights into potential treatments for individuals with sensory impairments.

PI_NAMEs: RODRIGUEZ-MORALES, ROBERTO E. (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Ablation;Address;Award;blind;career development;Cell Count;Central Nervous System;Compensation;confocal imaging;Coupled;Defect;design;Development;Elements;Embryo;Embryonic Development;Embryonic Eye;Environment;experience;experimental study;Eye;Eye Development;Feedback;Fishes;Genes;Genetic;Goals;graduate student;Grant;Hair Cells;Health;Hearing;Human;Hybrids;Immunohistochemistry;Individual;insight;Labyrinth;lateral line;Lead;lens;Link;Medical;Mentors;Mentorship;Mexican;Molecular;nerve supply;neuromast;neurotransmission;Pennsylvania;Phenotype;Photic Stimulation;Play;Population;Positioning Attribute;Postdoctoral Fellow;Process;Puerto Rico;Research;Role;Science;Scientist;Sensory;Sensory Hair;Sensory impairment;sensory system;Smell Perception;Structure;Surface;Synapses;synaptic inhibition;System;Testing;Training;trait;Transplantation;undergraduate student;United States National Institutes of Health;Universities;university student;Variant;Vision;Visual impairment;Visual System;Water;Work;Zebrafish

PROJECT_TITLE: Natural variation in synaptic neurotransmission of the lateral line in the blind Mexican cavefish

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-T (SF)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Chronic Pain;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pain Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: The University of Utah Program to Provide Pain Research Knowledge (UP3RK) mission is to impart the science knowledge, skills, and core competencies needed by post-graduate, interdisciplinary Scholars to address the nation’s scientific needs in clinical pain research. UP3RK trains Scholars through mentorship and concentrated training in: 1) our four focus areas (nonpharmacological pain treatments; effective interventions for pain and co-morbidities, particularly substance use disorders; implementation science; research within vulnerable, diverse, and underserved populations), 2) career development and programmatic skills, and 3) interdisciplinary research skills. We train Scholars through dedicated UP3RK Mentors within an innovative, multi-level mentor model develop independent clinical pain investigators and successful academic research careers.

PI_NAMEs: FRITZ, JULIE M (contact);GORDON, ADAM JOSEPH

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Address;Area;Behavioral;career;Career Choice;career development;Characteristics;Charge;chronic pain;Clinical;clinical pain;Clinical Research;cohort;Communication;comorbidity;Competence;Dedications;Educational Curriculum;effective intervention;Ensure;Environment;Evaluation;Funding;Grant;Health;implementation science;improved;innovation;Institution;Interdisciplinary Study;Knowledge;Medicine;Mentors;Mission;Modeling;next generation;novel;Pain;Pain management;Pain Research;Persons;Population Heterogeneity;Process;programs;recruit;Research;Research Personnel;Research Support;Science;Scientist;skills;Substance Use Disorder;Training;Training Activity;training opportunity;Underserved Population;Universities;Utah;Vulnerable Populations;Writing

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-F (90)]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: The NGRRC provides germ-free (GF, sterile) wild type and genetically-engineered gnotobiotic mice not available to most investigators due to the specialized technical expertise for their creation, breeding and study that are beyond the resources and expertise of most NIH grantees so they can explore host/microbe, microbe/ microbe and dietary/microbe interactions by examining physiologic and pathogenic differences in GF selectively colonized and conventionally raised mice, the functional relevance of bacterial genes, individual and defined microbial groups. Gnotobiotics enable precise microbial manipulation by colonizing GF normal, knockout or transgenic inbred mice with single or combined resident or pathogenic bacterial, viral or fungal species, including genetically engineered bacterial strains and by transplanting human fecal microbial communities into GF mouse recipients to explore their functional consequences. Overall Goal: Support broadly based basic and translational gnotobiotic research by local and national NIH-funded investigators with reliable, cost-effective, and easily accessed resources.

PI_NAMEs: SARTOR, RYAN B (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Address;Animal Experiments;Animal Model;Animals;Applications Grants;Atherosclerosis;autism spectrum disorder;Bacteria;bacterial community;Bacterial Genes;Behavioral;Biological Response Modifier Therapy;Breeding;Cell Separation;Cells;Cesarean section;Chronic Disease;Colon;Complex;cost effective;Data;deep sequencing;Diabetes Mellitus;Diet;dietary;Disease;disease phenotype;dysbiosis;Environmental Risk Factor;Etiology;experience;Exposure to;fecal microbiota;Film;flexibility;Funding;Funding Agency;Genes;Genetic Engineering;Genetic Predisposition to Disease;Genetic Risk;Genetically Engineered Mouse;Germ-Free;Gnotobiotic;Goals;Grant;host-microbe interactions;Housing;Human;human disease;Human Microbiome;Human Resources;Hypertension;Immunotherapy;improved;in vivo;Inbred Mouse;Individual;Infection;Inflammatory;Institution;Intramural Research Program;Knock-out;Link;Malignant neoplasm of pancreas;Mediating;Mental Depression;Metabolic;Metabolic syndrome;metabolomics;Microbe;microbial;microbial community;microbiota;Modeling;Monitor;Mouse Strains;multidisciplinary;multiple omics;Mus;Mutant Strains Mice;Mutate;National Institute of Allergy and Infectious Disease;National Institute of Environmental Health Sciences;Nature;neoplastic;nonalcoholic steatohepatitis;Obesity;Organ;Osteoporosis;Outcome;Paper;Parasites;Pathogenicity;Patients;Peer Review;Physiological;Physiological Processes;Physiology;Pilot Projects;Predisposition;Principal Investigator;Protocols documentation;Publishing;Quality Control;repository;Reproducibility of Results;Research;Research Personnel;Research Priority;Resources;response;Retroviridae;Rodent;Role;Series;Site;Sterility;Technical Expertise;Techniques;Tissue Banks;Tissues;Training;Transgenic Organisms;Transplantation;treatment response;United States National Institutes of Health;Universities;Viral;Virus;Yeasts

PROJECT_TITLE: National Gnotobiotic Resource Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-E (55)]


NIH_SPENDING_CATS: Genetics;Microbiome;Nutrition

PROJECT_TERMS: Address;Animal Experiments;Animal Model;Animals;Applications Grants;Atherosclerosis;autism spectrum disorder;Bacteria;bacterial community;Bacterial Genes;Behavioral;Biological Response Modifier Therapy;Breeding;Cell Separation;Cells;Cesarean section;Chronic Disease;Colon;Complex;cost effective;Data;deep sequencing;Diabetes Mellitus;Diet;dietary;Disease;disease phenotype;dysbiosis;Environmental Risk Factor;Etiology;experience;Exposure to;Film;flexibility;Funding;Funding Agency;Genes;Genetic Engineering;Genetic Predisposition to Disease;Genetic Risk;Genetically Engineered Mouse;Germ-Free;Gnotobiotic;Goals;Grant;host-microbe interactions;Housing;human disease;Human Microbiome;Human Resources;Hypertension;Immunotherapy;improved;Inbred Mouse;Individual;Infection;Inflammatory;Institution;Intramural Research Program;Knock-out;Link;Malignant neoplasm of pancreas;Mediating;Mental Depression;Metabolic;Metabolic syndrome;metabolomics;Microbe;microbial;microbial community;microbiota;Modeling;Monitor;Mouse Strains;multidisciplinary;multiple omics;Mus;Mutant Strains Mice;Mutate;National Institute of Allergy and Infectious Disease;National Institute of Environmental Health Sciences;Nature;neoplastic;nonalcoholic steatohepatitis;Obesity;Organ;Osteoporosis;Paper;Parasites;Pathogenicity;Peer Review;Physiological;Physiological Processes;Physiology;Pilot Projects;Predisposition;Principal Investigator;Publishing;Quality Control;Research;Research Personnel;Research Priority;Resources;response;Retroviridae;Rodent;Role;Series;Site;Sterility;Technical Expertise;Techniques;Tissue Banks;Tissues;Training;Transgenic Organisms;Transplantation;treatment response;United States National Institutes of Health;Universities;Viral;Virus;Yeasts


NIH_SPENDING_CATS: Genetics;Microbiome

PROJECT_TERMS: Advisory Committees;Annual Reports;autosome;Awareness;Bioinformatics;Biology;Biopsy;Breeding;Catalogs;Clinical Trials;Collection;Communication;cost;data repository;design;Development;Disease;Education;experience;FAIR principles;Feedback;Female;Funding;gastrointestinal;Gene Modified;Generations;Genetic;Genetic Drift;genetic strain;Genotype;Germ-Free;Gnotobiotic;Goals;Grant;Human;human disease;Human Resources;Improve Access;improved;Individual;Industry Standard;Informatics;Internet;Knowledge;Leadership;Link;male;microbial;Mouse Strains;multidisciplinary;Mus;Outcome;Phenotype;Practice Management;Publications;Publishing;Reliability of Results;Reporting;repository;Reproducibility;Resources;response;Services;Sex Chromosomes;Single Nucleotide Polymorphism;skills;Suggestion;Surveys;Tail;Techniques;Technology;Time;tool;Training;TRUST principles;United States National Institutes of Health;Validation;web page;web portal;web site


NIH_SPENDING_CATS: Microbiome

PROJECT_TERMS: Address;Aerobic;Affect;Aliquot;Animal Experiments;Anorexia;Asthma;Atherosclerosis;autism spectrum disorder;Bacteria;bacterial community;Behavior Disorders;Behavioral;clinical heterogeneity;clinically relevant;Colitis;Colon Carcinoma;Communities;Complex;Crohn's disease;Data;deep sequencing;Diabetes Mellitus;Disease;dysbiosis;fecal microbiota;fecal transplantation;Feces;Frequencies;Funding;Genetic Engineering;Genetically Engineered Mouse;Germ-Free;Gnotobiotic;Goals;Housing;Human;human disease;human microbiota;improved;in vivo;in vivo evaluation;Inbred Mouse;Individual;Inflammatory;Link;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Mental Depression;Metabolic;Metabolic syndrome;metabolomics;Methods;Microbe;microbial;microbiota;Modeling;mouse model;Mus;Nature;neoplastic;nonalcoholic steatohepatitis;novel therapeutics;Obesity;Oral;Organ;Outcome;Pathogenesis;Pathogenicity;Patients;Phenotype;Physiological;pre-clinical;Pre-Clinical Model;Predisposition;Property;Protocols documentation;Rectal Administration;repository;Reproducibility;Reproducibility of Results;Research;Research Personnel;Resources;response;Role;Sampling;Shipping;Source;Sterility;stool sample;Stress;Techniques;Testing;Therapeutic;Transplant Recipients;Transplantation;Uncertainty


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Immunotherapy;Infectious Diseases;Neurosciences;Pain Research;Urologic Diseases

ORG_CITY: RICHARDSON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: PROJECT NARRATIVE Antimicrobial peptides named defensins are detected in patient urine following urinary tract infections (UTIs), but their functions are not clear. We will utilize newly developed Defensin cluster knockout mice to reveal how defensins regulate urinary immunity and pain during UTI. Successful completion of the project will aid the development of immune therapies to treat UTI and the associated pelvic pain.

PI_NAMEs: DONG, XINTONG  (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Affect;Afferent Neurons;Animal Model;Animals;Anti-Bacterial Agents;anti-microbial peptide;Antibiotics;Area;Bacteria;bacterial community;Benign;Bladder;Bladder Tissue;Cell Culture Techniques;Cell Surface Receptors;cell type;Cells;Cellular biology;Cellular Immunity;Defense Mechanisms;Defensins;Dendritic Cells;Development;Dissection;Dyes;effective therapy;Elderly woman;Epithelial Cells;Epithelium;Escherichia coli Infections;extracellular;Family;Flare;Frequencies;Functional disorder;Future;G-Protein-Coupled Receptors;Genes;Genetic;genetic approach;Goals;host-microbe interactions;Human;Immune;Immune response;Immune Targeting;Immunity;Immunology;Immunomodulators;Immunotherapy;improved;Infection;Inflammatory;innovation;insect defensin A;Invaded;Knock-out;knockout animal;Knockout Mice;Knowledge;Label;live cell imaging;Location;loss of function;mast cell;Measures;Mediating;member;mouse model;multidisciplinary;Mus;Names;Natural Immunity;Neuroimmune;Neurons;neurotransmission;neutrophil;next generation;Nociceptors;novel;Pain;pain behavior;Pain Measurement;Patient-Focused Outcomes;Patients;Pelvic Pain;Peptides;Phenotype;Population;Postdoctoral Fellow;programs;receptor;Receptor Cell;Recurrence;Research;response;Role;side effect;signal recognition particle receptor;Signal Transduction;single-cell RNA sequencing;Skin;Spinal Ganglia;Surveys;Testing;Tissues;tool;transcriptome;Urethra;urinary;Urinary system;Urinary tract;Urinary tract infection;Urination;Urine;Urology;Uropathogen;Uropathogenic E. coli;Work

PROJECT_TITLE: Genetic dissection of defensin signaling in urinary tract infections

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]