NIH_SPENDING_CATS: Aging;Biotechnology;Breast Cancer;Cancer;Women's Health Research

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative This revised proposal will greatly augment our collective understanding of the mechanisms governing the basic etiology and pathobiology of breast cancer following mitophagic induction and its relationship to proliferation and migration. This R03 grant application will establish feasibility and proof of concept that mitostatin is a fundamental tumor suppressor gene that robustly inhibits breast cancer growth and metastasis by evoking mitophagy. The expected outcomes and scientific knowledge collected and gleaned from our detailed studies have the potential to establish mitostatin as a prime candidate for novel therapeutic approaches to combat primary and metastatic breast cancer.

PI_NAMEs: IOZZO, RENATO V. (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: 3-Dimensional;Accounting;Affect;Allografting;Animal Model;Applications Grants;Binding;Biological;Breast Cancer Cell;Breast Cancer Patient;Breast Cancer Prevention;breast cancer progression;breast cancer survival;Breast Carcinoma;breast tumorigenesis;cancer diagnosis;Cancer Etiology;cancer subtypes;Cell Line;Cell model;Clinical;combat;Data;Diagnosis;Distant;Etiology;fighting;flexibility;genetically modified cells;Glean;Goals;Growth;high reward;high risk;Human;improved;In Vitro;in vivo;inhibitor;innovation;insight;Investigation;Knowledge;Label;Luciferases;Malignant Breast Neoplasm;Mammary Tumorigenesis;Mediating;Medical;Messenger RNA;Metastatic breast cancer;migration;Mitochondria;mitochondrial autophagy;Modeling;Molecular;molecular subtypes;mouse model;Mus;Mutate;Neoplasm Metastasis;neoplastic cell;next generation;novel;novel therapeutic intervention;Organ;Outcome;Pathway interactions;Patients;pre-clinical;preclinical study;Process;Proliferating;Property;Proteins;Proteomics;Relapse;Reporter;response;RNA Interference;Role;Signal Transduction;Sirolimus;Stimulus;System;Therapeutic;Therapeutic Intervention;tumor;tumor diagnosis;Tumor Suppressor Genes;tumor xenograft;tumorigenic;Validation;Woman;women's diagnosis

PROJECT_TITLE: Mitostatin-evoked mitophagy for breast cancer inhibition


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Telehealth

ORG_CITY: BRONX

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE CLINICAL CORE The CC performs the essential role of rigorous clinical characterization of study participants to create a common foundation for use by the other Cores and Projects, including baseline assessment of cognitive status and progression over time. It is innovative in its use of both conventional and ambulatory methods to elucidate risk factors and cognitive outcomes in individuals’ natural environments. The CC has a strong track-record utilizing multiple modes of data collection, including telephone evaluations, in-person and virtual visits, ambulatory assessments, and at-home surveys to characterize participants.

PI_NAMEs: LIPTON, RICHARD B. (contact)

PROJECT_TERMS: Aging;Alzheimer's disease related dementia;Amyloid;Autophagocytosis;Autopsy;Behavior;Behavioral;Biological Assay;Biological Markers;Biological Specimen Banks;Blood Banks;Blood Pressure;Blood specimen;Brain;Cellular Phone;Charge;Clinic;Clinical;Clinical Data;clinical diagnostics;Cognitive;cognitive performance;cognitive testing;cohort;Collection;Communities;Consensus;Consent;COVID-19 pandemic;Data;Data Collection;data exchange;data management;Data Set;Databases;Dementia;Devices;Diagnosis;Diagnostic;Disease;Eligibility Determination;eligible participant;Enrollment;Ensure;Environment;Epidemiology;ethnic diversity;Etiology;Evaluation;Fasting;flexibility;follow-up;Foundations;Funding;Future;Genetic study;Home;Hybrids;Impaired cognition;impression;Individual;Inflammation;informant;Informed Consent;innovation;Magnetic Resonance Imaging;Measures;Medical;Medical History;Methods;mild cognitive impairment;mobile computing;Nerve Degeneration;neuroimaging;Neurologic;Neurologic Examination;Neurological Nursing;neuropathology;Neuropsychology;Nurse Practitioners;Outcome;Participant;Pathologic;Periodicals;Persons;Physiologic Monitoring;Procedures;Process;programs;Protocols documentation;psychologic;psychosocial;Questionnaires;racial diversity;Recording of previous events;recruit;remote monitoring;Reporting;Risk Factors;Role;Safety;Sampling;smartphone based device;social;Specimen;Standardization;Surveys;symposium;Syndrome;System;Tablets;tau Proteins;Techniques;Technology;Telephone;Testing;Time;Training;virtual;virtual visit;Visit;wearable device

PROJECT_TITLE: Clinical Core


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative: Sporadic frontotemporal lobar degeneration (sFTLD) and sporadic amyotrophic lateral sclerosis (sALS) are two progressive and incurable neurodegenerative disorders along a spectrum of diseases related the RNA/DNA binding protein TAR DNA-binding Protein of 43 kDa (TDP-43). We have generated a novel mouse model of endogenous TDP-43 proteinopathy and sFTLD-ALS that recapitulates key disease hallmarks, thereby providing a platform to interrogate pathogenic mechanisms in sporadic disease. This project will investigate the role of an aberrant TDP-43 species in age-dependent neurodegeneration and impaired protein homeostasis, with the long- term goal of elucidating opportunities for therapeutic intervention.

PI_NAMEs: NECARSULMER, JULIE CHRISTINE (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Acetylation;Affect;Age;age related;age related neurodegeneration;Aging;ALS patients;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Animal Model;Autophagocytosis;Basic Science;Behavior;Behavioral;Behavioral Assay;Biochemical;Biological Assay;Biological Models;Biology;Brain Stem;career;Caring;Cells;Characteristics;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;Complement;confocal imaging;Cortical Cord;CRISPR/Cas technology;Data;Dementia;Dementia with Lewy Bodies;Diagnostic;Disease;Disease Progression;disease-causing mutation;DNA Sequence Alteration;DNA-Binding Proteins;Electromyography;Electrophysiology (science);Elements;emotion regulation;Etiology;experimental study;familial amyotrophic lateral sclerosis;Family;frontal lobe;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Genes;genetic variant;Glutamine;Goals;Hand Strength;Hindlimb;Human Pathology;Imaging Techniques;Impaired cognition;Impairment;In Vitro;insight;Learning;Link;live cell imaging;Lysine;Measures;Mentors;Methods;Modeling;Motor;Motor Cortex;motor deficit;Motor Neuron Disease;Motor Neurons;mouse model;Mus;Mutation;Nerve Degeneration;neurodegenerative dementia;Neurodegenerative Disorders;neurodegenerative phenotype;neuroinflammation;Neuromuscular Diseases;neuromuscular function;Neuronal Dysfunction;Neurons;neuropathology;neurotoxicity;novel;overexpression;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Personality;pharmacologic;Phenotype;Physicians;Physiological;Point Mutation;protein TDP-43;Proteins;proteostasis;proteostasis loss;Rare Diseases;Recording of previous events;Research;Research Methodology;Risk Behaviors;RNA;RNA Binding;Role;Scientist;Side;Social Behavior;social deficits;Speech;Spinal Cord;sporadic amyotrophic lateral sclerosis;Syndrome;TDP-43 aggregation;Techniques;Testing;Therapeutic Intervention;Tissues;Training;Translational Research;Work

PROJECT_TITLE: A novel mouse model of TDP-43 Proteinopathy in FTLD-ALS: Elucidating the role of TDP-43 acetylation in neurodegeneration and proteostasis impairment


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

PHR: NARRATIVE BIOMARKER CORE The Biomarker Core will evaluate blood-based biomarkers that assess: 1) Alzheimer’s Disease and Related Dementias(ADRD) including amyloid, tau and neurodegeneration, 2) genetics, 3) blood chemistry, and 4) autophagy. In addition, a magnetic resonance imaging (MRI) sub-study will be conducted to provide cross- sectional measures of brain structure and physiology. Biomarkers will be used to improve diagnostic accuracy and inform the assessment of pathways linking novel risk factors to conventional and intensively measured cognitive outcomes.

PI_NAMEs: PAVLOVI, JELENA  (contact)

PROJECT_TERMS: Affect;age related biomarkers;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Anemia;Anisotropy;Apolipoprotein E;Autophagocytosis;Biological Markers;Blood;Blood Chemical Analysis;blood glucose regulation;Blood Urea Nitrogen;Blood Vessels;blood-based biomarker;Brain;C-reactive protein;Candidate Disease Gene;cardiovascular risk factor;Categories;Cerebrovascular Circulation;Cerebrovascular Physiology;Cholesterol;Classification;Clinical;Cognitive;cognitive function;cohort;Communities;comorbidity;Complement;Creatinine;data management;data sharing;dementia risk;diagnostic accuracy;Dimensions;DNA Methylation;Ensure;Folic Acid;Genetic;Genetic Diseases;Genetic Markers;genetic variant;genome wide association study;genomic biomarker;Genomics;Genotype;Glial Fibrillary Acidic Protein;Glucose;glucose metabolism;Glycosylated hemoglobin A;Health;heart disease risk;Hemorrhage;High Density Lipoproteins;Homocysteine;Impaired cognition;improved;indexing;Individual;Infarction;inflammatory marker;innovation;Insulin;interest;Length;Light;Link;Lipids;Magnetic Resonance Imaging;Measures;Mediating;Mediator;Molecular Chaperones;monocyte;Nerve Degeneration;neurofilament;Neurons;neuropathology;novel;novel marker;older adult;Outcome;Outcome Assessment;Participant;Pathologic;Pathology;Pathway interactions;Physiological;Physiology;Play;pre-clinical;Process;programs;racial diversity;Renal function;Rest;Risk Factors;Role;Sampling;Single Nucleotide Polymorphism;Statistical Data Interpretation;Structure;systemic inflammatory response;T-Lymphocyte;tau Proteins;Technology;telomere;Transcranial Doppler Ultrasonography;Triglycerides;Vascular Diseases;White Matter Hyperintensity;Work

PROJECT_TITLE: Biomarker Core


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Nanotechnology;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: CORVALLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative: Inherited retinal degenerations affect ~200,00 people in the USA and ~4.5 million world-wide. This project aims to develop cell-specific nanoparticles that deliver genetic cargo to the retina for the treatment of blindness.

PI_NAMEs: SAHAY, GAURAV  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Affect;Age;Amyloidosis;autosome;Bacteriophages;base;Binding;Biological;Biological Assay;Blindness;Cell Line;Cells;COVID-19 vaccine;Data;deep sequencing;Deoxyribonucleases;Dependovirus;Development;Dissociation;DNA;DNA delivery;Docking;efficacy evaluation;Electroretinography;Encapsulated;Endosomes;experimental study;Family;FDA approved;Fluorescence-Activated Cell Sorting;Frequencies;functional loss;Gene Delivery;gene editing technology;gene therapy;Genes;Genetic;genetic variant;genome editing;genome editor;Goals;Green Fluorescent Proteins;human disease;In Vitro;in vivo;infancy;Inherited;inherited retinal degeneration;knock-down;Leucine Zippers;Libraries;Ligands;Link;lipid nanoparticle;Measurement;Measures;Mediating;Messenger RNA;Mitochondria;Modeling;mouse model;Mouse Protein;mRNA delivery;Mus;Mutation;nanoparticle delivery;Neural Retina;novel;nuclease;Patients;Pattern;Peptide Receptor;Peptides;Persons;Phage Display;photoreceptor degeneration;Photoreceptors;Population;Prealbumin;prime editing;prime editor;protein expression;Proteins;Publishing;Rare Diseases;receptor;receptor mediated endocytosis;Reporter Genes;Retina;Retinal Degeneration;Retinal Dystrophy;RNA Interference;Rodent Model;screening;sex;Sorting;Structure of retinal pigment epithelium;subretinal injection;Surface;System;Techniques;Thick;tool;Toxic effect;Transfection;transmission process;uptake;Viral Vector;Vision;Western Blotting

PROJECT_TITLE: Developing gene editing platforms for retinal degeneration.

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Data Science;Networking and Information Technology R&D (NITRD)

PHR: NARRATIVE: The Technology and Data Management (TDM) Core TDM Core develops and maintains a secure, central data repository and management system for efficiently managing the vast, diverse data collected in EAS Program Project, and provides consultative and technical support for all data operations. These functions of TDM Core are essential for the success of the EAS Program Project and will facilitate data sharing, dissemination and collaborations amongst the EAS team, with external collaborators, and with the broader research community.

PI_NAMEs: KATZ, MINDY  (contact)

PROJECT_TERMS: Aging;Ancillary Study;arm;Biological Markers;Charge;Classification;Clinic;Clinical;cohort;Cohort Studies;Collaborations;Communities;Computer software;Data;data access;Data Collection;data dictionary;data dissemination;data infrastructure;data integration;data integrity;data management;Data Management Resources;data pipeline;Data Provenance;data repository;data reuse;Data Security;Data Set;data sharing;Data Sources;Data Storage and Retrieval;data streams;Dementia;Deposition;Development;Devices;digital;diverse data;Failure;FAIR principles;Health protection;International;interoperability;Maintenance;Measurement;Measures;Memory;Metadata;Methods;mobile computing;neuropathology;operation;Patient Self-Report;Persons;Policies;preservation;prevent;Procedures;Process;programs;Property;Protocols documentation;Psychometrics;psychosocial;quality assurance;repository;Research;Research Personnel;response;Running;Secure;Security;sensor;statistics;success;Support System;technological innovation;Technology;Testing;theories;Training;United States National Institutes of Health;Validation;wearable device

PROJECT_TITLE: Technology Core


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Lung cancer is the leading cause of cancer-related mortality in the United States, leading to more deaths than the next three cancers combined. Among patients with metastatic disease, median survival is less than 1.5 years, and less than 6% of patients are alive after 5 years. Rational, novel, therapeutic approaches combining in situ vaccination with immune checkpoint blockade offer the possibility of significant improvements in outcomes for patients with lung cancer.

PI_NAMEs: LISBERG, AARON ELLIOTT (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Adenovirus Vector;Adverse event;anti-PD-L1;Antigen-Presenting Cells;Antigens;Antitumor Response;Autologous;Autologous Dendritic Cells;Biopsy;Blood;Blood specimen;California;Cancer Etiology;cancer immunotherapy;Cancer Patient;career development;CD8-Positive T-Lymphocytes;Cells;cellular transduction;Cessation of life;chemokine;Clinical;Clinical Data;Clinical Research;Clinical Trials;Clinical Trials Design;Correlation Studies;Cytometry;Data;dendritic cell vaccination;Dendritic Cells;Development;Development Plans;Disease;Doctor of Medicine;Doctor of Philosophy;Dose;Drug Targeting;Environment;enzyme linked immunospot assay;Exhibits;exome sequencing;experience;first-in-human;Fostering;FOXP3 gene;Funding;Gene Modified;Goals;Granzyme;Hematology;Human;Immune;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immunofluorescence Immunologic;Immunologic Markers;Immunologic Monitoring;Immunologics;Immunophenotyping;Immunotherapeutic agent;improved;In Situ;in situ vaccination;inhibitor;Injections;Institution;Interferon Type II;Intravenous;Lead;Ligands;Los Angeles;lymph nodes;Lymphocyte;Lymphocyte Activation;Lymphocytic Infiltrate;Malignant neoplasm of lung;Malignant Neoplasms;Master of Science;Maximum Tolerated Dose;Measures;Mediating;Medicine;Mentors;Mentorship;monocyte;mortality;Myeloid-derived suppressor cells;nano-string;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;objective response rate;Oncology;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;PD-1/PD-L1;Peer Review;pembrolizumab;perforin;peripheral blood;Phase I Clinical Trials;phase I trial;Phenotype;Physicians;Population;predicting response;prevent;Procedures;professor;programmed cell death ligand 1;programmed cell death protein 1;programs;Publishing;recruit;Regulatory T-Lymphocyte;Research;research clinical testing;Research Methodology;response;Role;Safety;Sampling;Scientist;Site;skills;Somatic Mutation;Specimen;T cell receptor repertoire sequencing;T-Lymphocyte;Therapeutic;therapy development;Tissues;Training;Translational Research;tumor;tumor microenvironment;Tumor Tissue;Tumor-Infiltrating Lymphocytes;United States;Universities

PROJECT_TITLE: Intratumoral Administration of CCL21-gene Modified Dendritic Cell With Intravenous Pembrolizumab for Advanced NSCLC

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Regenerative Medicine

ORG_CITY: CHICAGO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project Narrative Impaired intramembranous bone regeneration can lead to failure of orhopaedic implants or delayed fracture healing. The underlying mechanisms contributing to intramembranous bone regeneration remain unclear. This project will elucidate molecular and therapeutic strategies with important translational implications for patients that undergo orthopaedic procedures.

PI_NAMEs: KO, FRANK  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Ablation;Academic Medical Centers;Address;Advisory Committees;Allografting;Animals;Award;Biological Assay;Biomechanics;Biometry;bone;bone fracture repair;Bone Marrow;Bone Marrow Ablation;bone mass;Bone Regeneration;bone repair;care providers;career development;Cell Culture Techniques;Cells;Committee Members;Complement;Core Facility;Data;Development Plans;differentiation in vitro;Distraction Osteogenesis;Event;experience;Failure;Femur;Gene Expression;Gene Expression Profile;Genes;Goals;Grant;Histology;Immunohistochemistry;Impairment;Implant;implantation;improved;In Vitro;Injury;insight;Institution;intramembranous bone;Knock-out;Knowledge;Label;lectures;Light;Marrow;Mediating;Mentors;Micro Array Data;microCT;Microscopy;Modeling;Molecular;Molecular Biology;Molecular Medicine;Molecular Profiling;Mus;Natural regeneration;novel;novel therapeutics;Operative Surgical Procedures;Orthopedic Procedures;Orthopedic Surgery;Orthopedics;Osteoblasts;osteogenic;Pathway interactions;Patient Care;Patients;Periosteum;periostin;Phenotype;Play;Procedures;Process;professor;protein expression;Publications;Recovery;Regenerative pathway;Replacement Arthroplasty;Reporter;Research;research and development;Research Personnel;responsible research conduct;Rodent Model;Role;sample fixation;Science;Scientist;Series;Skeletal Development;skeletal disorder;skeletal stem cell;Sorting;spatiotemporal;stem cell biology;stem cells;substantia spongiosa;Technical Expertise;Therapeutic;Time;tissue regeneration;Tissues;tomography;Training;Up-Regulation;Vocational Guidance;Writing

PROJECT_TITLE: Role of periostin expressing cells in intramembranous bone regeneration

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Social Determinants of Health

PHR: NARRATIVE The Statistics Core’s contribution to the Program Project is essential and significant because it is needed (1) To ensure proper analysis of data for hypothesis testing and hypothesis generation; and (2) To ensure that the data collected in each project and core are optimally utilized for both project specific and cross-project analyses. These processes are essential to insure proper disseminations of the EAS resources to the scientific and greater communities.

PI_NAMEs: WANG, CUILING  (contact)

PROJECT_TERMS: actigraphy;Address;Aging;Air;Air Pollution;Alzheimer's Disease;Alzheimer's disease related dementia;Behavior;Behavioral;Biological Aging;Biological Markers;Biology;biopsychosocial;biopsychosocial factor;blood glucose regulation;Blood Vessels;Clinical assessments;Cognition;Cognitive;cognitive performance;cognitive testing;Collaborations;Communities;Complex;Continuous Glucose Monitor;Data;Data Analyses;data integration;data management;data quality;data streams;Development;Ecological momentary assessment;Ensure;Environmental Risk Factor;Evaluation;experience;Generations;Goals;Growth;handheld mobile device;Health;Health behavior;Impaired cognition;Individual;Inflammation;innovation;Interview;Joints;Leadership;Link;Longitudinal Studies;Manuscripts;Measurement;Measures;Mediation;member;Mental Depression;method development;Methodology;Methods;model building;Modeling;Monitor;multilevel analysis;Natural History;older adult;Outcome;Pathway interactions;Patient Self-Report;Persons;Physical activity;Play;Polysomnography;Positioning Attribute;power analysis;Process;programs;psychosocial;racial diversity;Recording of previous events;Recurrence;Research;Research Design;Research Personnel;Resources;Role;sedentary lifestyle;Services;Sleep;Statistical Methods;statistics;success;Surveys;Technology;Testing;Time;Variant;vascular factor;wearable device;Work

PROJECT_TITLE: Statistics Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: NARRATIVE A definite diagnosis of neurodegenerative disorders, such as Alzheimer’s disease, is only possible at autopsy, which also permits collection of brain tissue that can be used for research. The Neuropathology Core collects brain tissue on participants in the Einstein Aging Study for both diagnosis and to promote research on neurodegenerative disorders of the elderly.

PI_NAMEs: CHIN, STEVEN SUEY-MING (contact)

PROJECT_TERMS: Advanced Glycosylation End Products;Aging;alpha synuclein;Alzheimer's Disease;Amygdaloid structure;Amyloid;Antibodies;Astrocytes;Autophagocytosis;Autopsy;Axon;basal forebrain;Basal Nucleus of Meynert;Biological Markers;Biometry;Blood Vessels;Brain;Brain region;Brain Stem;brain tissue;Cardiovascular system;Case Study;Categories;cerebrovascular;cerebrovascular pathology;Cessation of life;Classification;Clinic;Clinical;cohort;Collection;Communication;Consent;Correlative Study;Data;data exchange;data management;Data Reporting;Databases;Dementia;Dementia with Lewy Bodies;demographics;Diagnosis;Diagnostic;diencephalon;digital;Digital Photography;Dissection;DNA;Elderly;Electronic Mail;Enrollment;Equipment and supply inventories;Evaluation;Excision;Family member;Freezing;frontal lobe;Genetic;Glass;Glial Fibrillary Acidic Protein;glycemic control;Harvest;Hippocampus;Histologic;Histopathology;Hospitals;Human Resources;Hypothalamic structure;immunocytochemistry;Immunohistochemistry;Left;Lentiform nucleus structure;Lesion;Leukoaraiosis;Lewy Bodies;Life;Link;Measures;Medical center;meetings;member;Methods;Microglia;Microscopy;Neurodegenerative Disorders;neurofilament;neuroinflammation;neuron loss;neuropathology;Paper;Paraffin;Participant;Pathologic;Pathology;Persons;Phase;pollutant;Procedures;programs;protein TDP-43;Protocols documentation;provider communication;Qualifying;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;research study;Research Support;RNA;sample fixation;Sample Size;screening;Services;Severities;Slide;Standardization;Substantia nigra structure;tau-1;Tauopathies;Telecommunications;Temporal Lobe;Thioflavin S;Tissue Extracts;tissue preparation;Tissues;tool;Transportation;Ubiquitin;Update;virtual;white matter;Writing

PROJECT_TITLE: Neuropathology Core


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Human cancer genome sequencing efforts have delivered an enormous amount of data on the genetic changes that occur during the process of carcinogenesis. Mathematical extraction of the complex data set reveals about 80 distinctive “mutational signatures” that hint at, but do not definitively prove, the molecular events that convert normal cells into cancer cells. Utilizing unique chemical and biological reagents, this proposal takes a bottom up approach to construct complex mutational signatures out of component parts, each of which is mechanistically well understood. 1

PI_NAMEs: ESSIGMANN, JOHN M (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: 8-hydroxyguanosine;Address;adduct;Adjuvant Therapy;Advanced Malignant Neoplasm;Aflatoxin B1;Alkylating Agents;Analytical Chemistry;Antigens;Area;base;Base Pairing;Base Sequence;Binding;Biological;Biological Models;Bypass;Cancer Biology;cancer cell;cancer genome;cancer immunotherapy;cancer therapy;carcinogenesis;Carcinogens;Cell Survival;Cells;Characteristics;chemical carcinogen;Chemicals;chemotherapy;chloroacetaldehyde;Chromosomal Probes;Cisplatin;Collection;Complex;complex data;Consensus;Custom;cytotoxic;Cytotoxic Chemotherapy;Data;Data Set;Databases;Deoxycytidine;Dependence;design;Development;DNA;DNA Adducts;DNA Binding;DNA biosynthesis;DNA Damage;DNA lesion;DNA Methylation;DNA Repair;DNA sequencing;Embryo;Environmental Carcinogens;Epoxy Compounds;Etiology;Evaluation;Event;experimental study;Fibroblasts;Frequencies;Genetic;genetic analysis;Genetic Engineering;Genome;genome sequencing;Genomics;Goals;Grant;Guanine;Human;immune checkpoint;in vivo;Individual;Inflammation;Informatics;Investigation;Isotopes;Kinetics;knock-down;Label;Laboratories;Lesion;Ligation;Malignant Neoplasms;Mammalian Cell;Maps;Mass Spectrum Analysis;Mathematics;Measures;Methylation;Methylnitrosourea;Modeling;Modernization;Molecular;Mus;Mutagenesis;Mutagens;Mutation;Mutation Spectra;N-nitrosodimethylamine;neoantigens;Normal Cell;novel;novel strategies;Nucleosides;Nucleotides;Oligonucleotides;Oxidants;oxidation;Oxidative Stress;Pattern;PD-1/PD-L1;Plasmid Cloning Vector;Polymerase;pre-clinical;Primary carcinoma of the liver cells;Process;Property;Protocols documentation;Reaction;Reagent;Refractory;Relaxation;repaired;Replication Error;Resolution;Role;Series;Site;Somatic Mutation;Source;Specificity;Spottings;Sterigmatocystin;Streptozocin;sugar;Synthesis Chemistry;Techniques;temozolomide;Testing;Time;tool;tumor;Viral Genome;Viral Vector;Work

PROJECT_TITLE: Intra and Extra-Chromosomal Probes for Mutagenesis by Carcinogens

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: PROJECT NARRATIVE Poor sleep health, low levels of physical activity and excessive sedentary behavior are common and modifiable factors that may be associated with increased risk for cognitive decline and Alzheimer’s Disease and related dementias (ADRD), but they have not been studied together. We will use ambulatory methods to study the joint effects of these behaviors on cognitive performance, decline and impairment in a diverse community sample of older adults.

PI_NAMEs: DERBY, CAROL A. (contact)

PROJECT_TERMS: actigraphy;Address;Advisory Committees;Aging;Alzheimer disease prevention;Alzheimer's disease related dementia;Alzheimer's disease risk;Anti-Inflammatory Agents;Behavior;Behavior Therapy;Biological Markers;Black Populations;Blood;Blood flow;Blood Vessels;brain health;cardiometabolic risk;cardiovascular risk factor;cerebrovascular;Cerebrovascular Circulation;cerebrovascular imaging;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive performance;cognitive testing;Cohort Studies;Communities;Complex;crosslink;cytokine;Data;Dementia;dementia risk;Demographic Factors;Diabetes Mellitus;Discrimination;Disease;Disparity;Economics;ethnic difference;experience;Financial Hardship;Guidelines;Health;Health behavior;Hour;Impaired cognition;Impairment;improved;Incidence;indexing;Individual;Inflammatory;Joints;Link;Literature;Measures;Mediating;Mediation;Mediator;Methods;mild cognitive impairment;Obesity;older adult;optimism;Outcome;Oxygen saturation measurement;Pathology;Pathway interactions;Patient Self-Report;Pattern;perceived discrimination;Physical activity;poor sleep;Prevalence;prevent;Prevention;programs;Psychosocial Factor;Race;racial difference;resilience;resilience factor;Resources;Risk;Role;Sampling;sedentary lifestyle;sensor;Sleep;Sleep disturbances;sleep health;sleep pattern;social;social stressor;Spirituality;Structure;Thigh structure;Time;Transcranial Doppler Ultrasonography;vascular factor;wearable device;Work;Wrist

PROJECT_TITLE: Sleep, Physical Activity, Sedentary Behavior and Cognitive Function


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cardiovascular;Heart Disease;Prevention;Women's Health Research

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Doxorubicin alone or its combination with kinase inhibitor are highly effective strategies for treatment of breast cancer but their utility is limited due to a major side effect involving heart failure. Currently there is no effective therapy available to reduce or eliminate the risk of heart failure in cancer patients treated with these agents. We propose to study a novel combination of phosphodiesterase 5 inhibitor, sildenafil (Viagra) and the potent anti-rejection drug, rapamycin to reduce cardiac side effects and improve the efficacy of breast cancer treatment with doxorubicin and doxorubicin with the kinase inhibitor.

PI_NAMEs: DAS, ANINDITA  (contact);KUKREJA, RAKESH C

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Adult;Antineoplastic Agents;attenuation;Basic Science;Breast Cancer Patient;Breast Cancer survivor;Breast Cancer Treatment;cancer cell;Cancer Control;Cancer Patient;cancer survival;Cancer Survivorship;cancer therapy;Cardiac;Cardiac Myocytes;Cardiomyopathies;cardioprotection;Cardiotoxicity;Cardiovascular system;cell killing;Cessation of life;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;Clinical Research;Clinical Trials;clinically relevant;Coculture Techniques;Combined Modality Therapy;Coupled;Cyclic GMP;Cyclic GMP-Dependent Protein Kinases;cytokine;Data;design;Development;diabetic;Dose;Doxorubicin;Early Diagnosis;Early treatment;effective therapy;Epidermal Growth Factor Receptor;ERBB2 gene;Erectile dysfunction;experience;FDA approved;FRAP1 gene;Heart;Heart Diseases;Heart failure;heart function;Heart Injuries;Human;Hypertrophy;IL18 gene;improved;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;inhibiting antibody;inhibitor;inhibitor therapy;Injury;innovation;interest;Interleukin-1 beta;kinase inhibitor;Laboratories;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Measures;Mediator;Medicine;Modeling;Modernization;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;mTOR inhibition;mTOR Inhibitor;Mus;Myocardial dysfunction;Myocardial Reperfusion Injury;Myocardium;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;Outcome Study;overexpression;Patients;Pharmaceutical Preparations;Phase I Clinical Trials;phosphodiesterase V;Play;Population;prevent;protective effect;Protein Kinase;Pulmonary Hypertension;Regimen;Research;Resistance development;response;Risk;Role;Sequential Treatment;side effect;Signal Pathway;Signal Transduction;sildenafil;Sirolimus;Survivors;Testing;Therapeutic;Therapeutic Effect;TLR4 gene;Transgenic Mice;Trastuzumab;Treatment Efficacy;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor progression;Viagra;Withholding Treatment;Woman;Work

PROJECT_TITLE: Novel Strategy of PDE5-mTOR Inhibition in Attenuation of Cancer  Drug Cardiotoxicity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: Narrative Statement of Public Health Past research has identified depression, inflammation, and accelerated biological aging as independent risk factors for Alzheimer’s disease and related dementias (ADRD); however, because these factors have typically not been investigated at the same time, it is unclear how they intersect to confer risk. This project will investigate the unique, cumulative, and interactive impact of depression, inflammation, and biological aging on cognitive decline and ADRD risk, and will help unpack the underpinnings of racial disparities. Ultimately, this project will pave the way for tailored preventative interventions to reduce risk of cognitive aging and decline.

PI_NAMEs: ENGELAND, CHRISTOPHER G (contact)

PROJECT_TERMS: Age;age acceleration;age related biomarkers;aged;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Anhedonia;Apolipoprotein E;attributable risk;Behavioral;Biological;biological age;Biological Aging;Biological Markers;biopsychosocial;Black race;Blood;Cause of Death;Classification;Cognitive;Cognitive aging;cognitive function;cognitive performance;cognitive testing;cohort;Data;Data Collection;Dementia;dementia risk;depressive symptoms;Development;Dimensions;Disparity;DNA Methylation;Ecological momentary assessment;ethnic diversity;Ethnic Origin;experience;functional outcomes;Future;Gender;health disparity;Hispanic;Immune;Impaired cognition;Incidence;Individual;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;innovation;Intervention;late life;Length;Major Depressive Disorder;Measures;Mediating;Mediation;men;Mental Depression;mild cognitive impairment;Modeling;Nerve Degeneration;Neuropsychology;novel strategies;older adult;Outcome;Pathway interactions;perceived discrimination;Plasma;Population;Predictive Value;Prevalence;preventive intervention;psychosocial;Psychosocial Factor;Public Health;Race;racial disparity;racial diversity;racial population;Recording of previous events;Research;Risk;Risk Factors;Risk Reduction;Role;sex;Socioeconomic Status;Stress;Structure;symptomatology;systemic inflammatory response;telomere;Testing;Time;Variant;Woman;Work

PROJECT_TITLE: Depression, Inflammation, Biological Age and Cognitive Function


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;HIV/AIDS;Infectious Diseases;Neurosciences;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PI_NAMEs: GLADSTONE, MELISSA ;LAUFER, MIRIAM K. (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: adaptive immunity;Address;Africa South of the Sahara;Age Months;antenatal;antiretroviral therapy;Assessment tool;Birth;Categories;Child;Child Health;Clinical Research;cohort;Communicable Diseases;Conceptions;Development;effective intervention;Enrollment;Exposure to;high risk;high risk infant;HIV;HIV Infections;immunological status;Immunologist;improved;in utero;Infant;Interdisciplinary Study;Intervention;Laboratories;Lead;Life;Long-Term Effects;longitudinal analysis;Malawi;Mothers;Neonatal;Neurocognitive;Neurocognitive Deficit;neurodevelopment;Outcome;pediatrician;Personal Satisfaction;Population;Pregnancy;Pregnant Women;prenatal exposure;Prior Therapy;Psychologist;Recording of previous events;Resource-limited setting;Risk Factors;Sample Size;screening;Specialist;Standardization;Testing;Translating;Viral Load result;Viremia;Visit;Woman;women's diagnosis

PROJECT_TITLE: Long-term neurocognitive outcomes of HIV-exposed uninfected children


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Mental Health;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE This study will collect person-level data on exposure to fine particulate matter (PM1, PM2.5) air pollution. Those data will be used to study the effects of this pollution on cognition and risk for Alzheimer’s Disease and Related Dementias (ADRD), biomarkers of AD/ADRD, and social determinants of health.

PI_NAMEs: HALL, CHARLES B (contact)

PROJECT_TERMS: abeta accumulation;Acute;Address;Age;aged;Aging;Air;Air Pollutants;Air Pollution;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;apolipoprotein E-4;Automobile Driving;Autopsy;Biological;Biological Markers;biomarker performance;Blood Vessels;Brain Pathology;Cardiovascular system;cerebrovascular;Characteristics;Chronic;Cognition;Cognitive;cognitive change;cognitive function;cognitive performance;contextual factors;Data;Data Collection;Dementia;Discrimination;Disparity;Ecological momentary assessment;Education;environmental stressor;ethnic difference;ethnic disparity;Ethnic Population;Event;Exposure to;Financial Hardship;fine particles;Floor;frontal lobe;Health;Heating;Heterogeneity;High Prevalence;Housing;indexing;Individual;Individual Differences;Indoor Air Quality;Inflammation;insight;Intelligence;Life;Light;Magnetic Resonance Imaging;Measurement;Measures;Mediation;Memory;men;Methodology;mild cognitive impairment;Monitor;monitoring device;Neighborhoods;Nerve Degeneration;neurofilament;Neuropsychology;non-verbal;Participant;Pathology;Pathway interactions;perceived discrimination;Persons;Pollution;Predisposition;Probability;Public Health;racial difference;racial disparity;racial population;Research;resilience;respiratory;Respiratory Disease;Risk;sensor;Serum;Smoking;social determinants;social health determinants;socioeconomic disparity;socioeconomics;Source;study population;Subgroup;tau Proteins;Time;traffic-related air pollution;verbal;wearable device;White Matter Hyperintensity;Woman

PROJECT_TITLE: Air Pollution and Cognitive Function


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Depression;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Obesity;Prevention;Sleep Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: PROJECT NARRATIVE: Type 2 diabetes is a risk factor for Alzheimer’s disease and related dementias, vascular dementia, mild cognitive impairment and accelerated cognitive decline. We proposed to expand the scope of science by incorporating continuous glucose monitoring paired with ambulatory cognitive assessments by smartphone to rigorously assess the relationships between blood glucose regulation and cognitive function in a racially and ethnically diverse at-risk population of older adults. This work will inform clinical care and the development of innovative interventions to optimize cognitive function for adults with type 2 diabetes.

PROJECT_TERMS: Acceleration;Acute;adaptive intervention;Address;Adult;Age;Aging;aging population;Air Pollution;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Autophagocytosis;biobehavior;Biological Markers;Blinded;Blood Glucose;blood glucose regulation;Blood Vessels;Caring;Cellular Phone;Characteristics;Clinical;clinical care;Cognition;Cognitive;cognitive change;cognitive function;cognitive performance;cognitive testing;Communities;Continuous Glucose Monitor;Coupled;Data;Data Collection;depressive symptoms;design;Development;Diabetes Mellitus;Ecological momentary assessment;Education;Enrollment;ethnic diversity;ethnic minority;Ethnic Origin;Exposure to;Failure;Fatigue;follow-up;Funding;glycemic control;Glycosylated hemoglobin A;Goals;Health;Hypoglycemia;Impaired cognition;indexing;Individual;individual patient;individualized medicine;Inflammation;innovation;Intervention;Link;Long-Term Effects;Measurement;Measures;Mediator;Mental Depression;mild cognitive impairment;Modeling;Monitor;negative affect;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Obesity Epidemic;older adult;Outcome;Parents;Participant;Patients;Persons;Physical activity;Population;Populations at Risk;Prevalence;Quality of life;Race;racial diversity;racial minority;Recommendation;recruit;Reporting;Research;Research Personnel;Risk;Risk Factors;Risk Reduction;Sampling;Science;sex;Sleep;sleep quality;socioeconomic disadvantage;standard measure;Surveys;tau Proteins;Technology;Time;Time Series Analysis;underserved community;Variant;Vascular Dementia;Vascular Diseases;Work

PROJECT_TITLE: Glucose Regulation and Cognitive Function in Type 2 Diabetes


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Breastfeeding, Lactation and Breast Milk;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pediatric;Pneumonia and Influenza;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE Infants are the highest risk pediatric group for severe morbidity and mortality related to influenza and require unique interventions to protect them. Maternal influenza immunization reduces infections in these children, but research is needed to better understand how maternal vaccine protects infants and how it may be optimized to reduce infant infections. By comprehensively studying the role of maternal influenza immunization in the protection of infants against influenza, this project will directly inform efforts to improve delivery of influenza vaccine to pregnant women and influenza-related outcomes for infants.

PI_NAMEs: RICK, ANNE-MARIE  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Acute;Address;Adult;Affect;Age;Age Months;Antibodies;Antibody titer measurement;antibody transfer;Antibody-mediated protection;Antigens;Applications Grants;Biological Assay;Blood;booster vaccine;Breast Feeding;career development;Case/Control Studies;Centers for Disease Control and Prevention (U.S.);Cessation of life;Child;Childhood;Clinical;clinical practice;cohort;Communicable Diseases;comparison control;Consumption;Counseling;Data;didactic education;Disease;Electronic Health Record;Enrollment;Enzyme-Linked Immunosorbent Assay;Epidemiology;Equation;Evaluation;experience;Exposure to;feeding;Funding;Future;Goals;Hemagglutinin;high risk infant;hospitalization rates;Human Milk;Human Subject Research;Immunization;Immunize;Immunoglobulin G;Immunologics;Immunology;improved;Individual;infancy;Infant;Infant Health;infant infection;infant outcome;Infection;Influenza;influenza infection;Influenza vaccination;influenza virus vaccine;inhibiting antibody;innovation;Institution;Intervention;Investigation;Knowledge;Laboratories;laboratory experience;Lead;Leadership;Link;Logistic Regressions;Longitudinal cohort study;maternal serum;Measures;Mediating;Medical center;Mentors;Mentorship;Methods;Mission;Morbidity - disease rate;mortality;Mothers;National Institute of Allergy and Infectious Disease;Nose;novel;novel vaccines;Parents;Pharyngeal structure;Placenta;Positioning Attribute;Pregnancy;Pregnant Women;prevent;protective effect;Race;recruit;Reporting;Research;Research Design;Research Personnel;Research Training;respiratory;Retrospective cohort;Risk;Risk Reduction;Role;Science;seasonal influenza;Second Pregnancy Trimester;Serum;sex;skills;Specimen;surveillance network;Swab;Testing;United States;Universities;University resources;Vaccinated;vaccination strategy;Vaccine Research;vaccine response;vaccine-induced antibodies;Vaccines;Variant;Visit;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Infant Protection from Influenza through Maternal Influenza Immunization

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Neurosciences;Prevention

ORG_CITY: HOBOKEN

ORG_NAME: THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY

ORG_STATE: NJ

PHR: Project Narrative Detection of clinical diabetic retinopathy (DR) can take several years from the onset of diabetes; hence, the long preclinical phase should provide a window to apply interventions that can slow or prevent progression to clinical endpoint (mild to severe visual impairment). Since the retinal vessels are early and prevalent targets of diabetic damage, sensitive identifiers of blood vessel changes hold great potential as biomarkers. Using a novel dynamic tracer kinetic model to quantitatively measure retinal vascular permeability and blood flow changes based on the fluorescein video-angiography imaging modality, the goal of this study is to demonstrate that the proposed dynamic tracer kinetic model can detect preclinical DR with a higher sensitivity and specificity than other retinal imaging modalities.

PI_NAMEs: KANG-MIELER, JENNIFER J (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Acceleration;adaptive optics scanning laser ophthalmoscopy;Address;Angiography;Angiotensin II Receptor;Angiotensin-Converting Enzyme Inhibitors;Area;Biochemical;Biological Markers;Blindness;Blood flow;blood flow measurement;Blood Vessels;Centers for Disease Control and Prevention (U.S.);Characteristics;Clinical;clinical examination;clinical practice;Clinical Sensitivity;Data;data acquisition;Detection;detection sensitivity;Diabetes Mellitus;diabetic;diabetic patient;Diabetic Retinopathy;Dose;Early Diagnosis;Early treatment;Ensure;Evans blue stain;Fluorescein;Fluorescein Angiography;Genetic;Goals;Growth Factor Inhibition;high risk;Hyperglycemia;Imaging Device;imaging modality;Imaging technology;Intervention;kinetic model;Measurement;Measures;Methods;Microspheres;Modeling;Morphologic artifacts;Motion;Nature;novel;novel therapeutics;Optical Coherence Tomography;Patients;Perfusion;Pericytes;Permeability;Phase;polyol;pre-clinical;prevent;Production;Protein Kinase C;Receiver Operating Characteristics;Reporting;Retina;retina blood vessel structure;retinal damage;Retinal Diseases;retinal imaging;Rodent Model;Scanning;Sensitivity and Specificity;Severities;statistics;structural determinants;success;Surrogate Endpoint;Techniques;Technology;tool;Tracer;Translating;uptake;Vascular Endothelial Growth Factors;Vascular Permeabilities;Vascular remodeling;Vision;Visual impairment;Visualization;X-Ray Computed Tomography

PROJECT_TITLE: Dynamic Tracer Kinetic Model to Detect Preclinical Diabetic Retinopathy (DR)


ADMINISTERING_IC: DK

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Genetics;Transplantation

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Diabetes is a global health epidemic caused by the destruction and/or dysfunction of pancreatic β cells. This project focuses on elucidating the role of the transcriptional cofactor CHD4 during the development and function of pancreatic β cells. This knowledge will be essential in establishing better differentiation protocols for generating fully functional β cells from human pluripotent stem cells.

PI_NAMEs: SARBAUGH, DYLAN  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Adult;Affect;Age;Beta Cell;Binding;Biological Assay;Blood Glucose;Cadaver;Cell Line;Cell Physiology;cell replacement therapy;Cells;CHD4 gene;ChIP-seq;Chromatin;Co-Immunoprecipitations;cofactor;combat;Complex;conditional knockout;Data;Deacetylase;Defect;Development;Diabetes Mellitus;diabetic patient;differentiation protocol;directed differentiation;Donor person;endocrine pancreas development;Enterobacteria phage P1 Cre recombinase;Epidemic;Etiology;experimental study;Functional disorder;gene repression;genetic corepressor;Genetic Transcription;Genomics;global health;Glucose;Glucose Intolerance;HDAC1 gene;histone modification;Hormones;Human;human pluripotent stem cell;Hyperglycemia;In Vitro;in vivo;Insulin;insulin secretion;islet;Islet Cell;Islets of Langerhans Transplantation;knock-down;Knowledge;Mass Spectrum Analysis;Mediating;Metabolic;Methods;Molecular;Motor;Mus;Mutant Strains Mice;Non-Insulin-Dependent Diabetes Mellitus;novel;Nucleosomes;Occupations;Pancreas;Pancreas Transplantation;Patients;Play;pluripotent stem cell differentiation;Population;programs;Proteins;recruit;Research Personnel;Role;Severities;Stains;Structure of beta Cell of islet;success;Testing;Time;transcription factor;Transcriptional Regulation;transcriptome sequencing;type I and type II diabetes

PROJECT_TITLE: CHD4-MEDIATED TRANSCRIPTIONAL REGULATION OF PANCREATIC BETA CELL DEVELOPMENT AND FUNCTION


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: HOUSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because systematic characterization of RNA modifications in large, well-characterized clinical patient cohorts is expected to advance our understanding of the molecular basis of human cancers, thereby helping the development of more effective treatment approaches. Thus, this project is relevant to the NIH's mission to develop fundamental knowledge that will help to reduce the burdens of human disability.

PI_NAMEs: LIANG, HAN  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Alternative Splicing;anti-cancer research;Bioinformatics;bioinformatics resource;Biological;Biological Markers;Biology;Biomedical Research;Cancer Biology;cancer biomarkers;Cancer cell line;cancer genomics;cancer initiation;Cancer Patient;cancer therapy;cancer type;Chicago;Classification;Clinical;clinically relevant;cohort;Colorectal Cancer;Communities;Computational Biology;Computer Analysis;Data;Databases;deep learning;Development;Dimensions;disability;Disease;effective therapy;Event;genome resource;genome-wide;Genomics;Goals;Human;innovation;Investigation;Knowledge;Life Cycle Stages;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Messenger RNA;methylation pattern;Mission;Modeling;Modification;Molecular;Molecular Abnormality;novel;Outcome;Pathogenesis;Patients;Pattern;Phase;Phosphorylation;Play;Polyadenylation;potential biomarker;predictive modeling;Process;prognostic;Protein Array;protein biomarkers;protein expression;Proteomics;Protocols documentation;Public Health;Qualifying;Reader;Research;Resources;RNA;RNA Editing;RNA methylation;Role;Sampling;Skin Cancer;Standardization;The Cancer Genome Atlas;Therapeutic;therapeutic target;tumor;Tumor Subtype;United States National Institutes of Health;Universities;user-friendly

PROJECT_TITLE: Characterization and modeling of m6A RNA methylation in cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative (Overall Component, RFA-CA-22-040) We propose to develop a blood-based test whose indicated use is to complement mammography in the early detection of breast cancers. Using a novel biomarker discovery approach leveraging human-in-mouse breast cancer patient-derived xenograft models and state-of-the-art mass spectrometry methods, we previously prioritized 162 candidate blood-based breast cancer protein biomarkers for validation studies. This project will perform EDRN Phase 2 biomarker validation studies of our prioritized 162 candidate plasma protein biomarkers of breast cancer, using clinical grade immuno-MRM assays run in our CLIA Laboratories to analyze strongly unbiased collections of plasma to evaluate the performance metrics of single or multiple protein panels in EDRN phase 2 case-control validation studies.

PI_NAMEs: HOOFNAGLE, ANDREW N;PAULOVICH, AMANDA G (contact);WANG, PEI

PROGRAM_OFFICER_NAME: FU, SIDNEY WANG

PROJECT_TERMS: Aliquot;Atypia;Benign;Biological Assay;Biological Markers;biomarker development;biomarker discovery;biomarker validation;Biometry;Blinded;Blood;Blood Tests;Breast;Breast Cancer Early Detection;breast imaging;breast lesion;Budgets;cancer biomarkers;cancer invasiveness;candidate marker;case control;CLIA certified;Clinical;clinical diagnostics;Clinical Oncology;Collaborations;Collection;Communication;Complement;Contracts;Data;Development;Diagnosis;Documentation;early detection biomarkers;Early Detection Research Network;Early Diagnosis;Ensure;Environment;Enzyme-Linked Immunosorbent Assay;Epidemiology;ethnic diversity;experience;Flow Cytometry;follow-up;Generations;Guidelines;high risk;Human;human tissue;improved;Industry;industry partner;Institutional Review Boards;Laboratories;laboratory development;Logistics;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Mass Spectrum Analysis;Measurement;Methods;Monitor;Mucin 1 protein;multidisciplinary;Mus;Neoplasm Transplantation;next generation sequencing;novel marker;novel strategies;Office of Administrative Management;Pathology;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Performance;Phase;Plasma;Plasma Proteins;pre-clinical;Procedures;Productivity;Progress Reports;Proliferative Type Breast Fibrocystic Change;protein biomarkers;Proteins;Qualifying;Race;Radiology Specialty;Reaction;Reagent;Research Design;Research Personnel;Running;Screening for cancer;screening guidelines;Site Visit;Specificity;Target Populations;Testing;timeline;Transplantation;Travel;trend;Tumor-Derived;United States;Validation;validation studies;Woman;Xenograft procedure

PROJECT_TITLE: Breast-cancer focused biomarker characterization center employing targeted mass spec assays in a CLIA environment


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Prevention;Women's Health Research

PI_NAMEs: PAULOVICH, AMANDA G (contact)

PROJECT_TERMS: Administrator;biobank;Biological Assay;Biological Markers;biomarker discovery;biomarker validation;Blood;Blood Tests;Breast;Breast Cancer Early Detection;Budgets;cancer biomarkers;candidate marker;candidate validation;Certification;Clinical;Communication;Complement;Contracts;Development;Documentation;Early Detection Research Network;Early Diagnosis;Ensure;Environment;experience;follow-up;Grant;high risk;Human;improved;industry partner;Institutional Review Boards;Laboratories;Logistics;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Manuscripts;Mass Spectrum Analysis;member;Methods;Mucin 1 protein;multiple reaction monitoring;Mus;National Cancer Institute;novel;novel marker;operation;Patient-derived xenograft models of breast cancer;Phase;Plasma;Plasma Proteins;pre-clinical;Productivity;programs;Progress Reports;protein biomarkers;Proteomics;Qualifying;Sampling;screening guidelines;Site Visit;Specificity;Target Populations;Testing;timeline;Travel;tumor;United States;Universities;validation studies;Washington;Woman

PROJECT_TITLE: Admin Core


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MILWAUKEE

ORG_DEPT: CHEMISTRY

ORG_NAME: MARQUETTE UNIVERSITY

ORG_STATE: WI

PHR: Project Narrative  To meet the increasing demands for safer, yet effective medicines, scientists are using deuterated small molecules to develop novel therapeutics. Despite the tremendous advantages and recent success of deuterated medicines, highly selective chemical reactions to access novel deuterated small molecules and the analytical spectroscopic techniques to support developing these reactions are severely lagging. The proposed research is designed to modernize the synthesis of deuterated small molecules and to advance the field of regioselective aryl alkyne hydrofunctionalization chemistry.

PI_NAMEs: CLARK, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Highly Selective Cu-Catalyzed Reactions for Precision Deuteration and Alkyne Hydrofunctionalization


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Precision Medicine;Prevention;Women's Health Research

PROJECT_TERMS: Aliquot;Antibodies;Atypia;Benign;biobank;Biological Assay;Biological Markers;biomarker development;biomarker discovery;biomarker validation;Biometry;Blinded;Blood;Blood Tests;Breast;Breast Cancer Early Detection;breast imaging;breast lesion;cancer biomarkers;cancer invasiveness;candidate marker;Clinical;clinical assay development;clinical diagnostics;clinical implementation;Clinical Oncology;Collaborations;Complement;Data;Development;Diagnosis;early detection biomarkers;Early Detection Research Network;Early Diagnosis;Ensure;Environment;Epidemiology;ethnic diversity;follow-up;Generations;Guidelines;high risk;Human;human tissue;improved;Industry;Isotopes;Laboratories;laboratory development;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Mass Spectrum Analysis;Measurement;Methods;Monitor;Mucin 1 protein;multidisciplinary;multiple reaction monitoring;Mus;Neoplasm Transplantation;novel;novel marker;novel strategies;Pathology;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Performance;Phase;Plasma;Plasma Proteins;pre-clinical;Productivity;Proliferative Type Breast Fibrocystic Change;protein biomarkers;Proteins;Protocols documentation;Qualifying;Race;Radiology Specialty;Reaction;Reagent;repository;Research Design;Sampling;screening;Screening for cancer;screening guidelines;Specific qualifier value;Specificity;Statistical Data Interpretation;Target Populations;Testing;Transplantation;trend;Tumor-Derived;United States;Validation;validation studies;Woman;Xenograft procedure

PROJECT_TITLE: Core - Biomarker Developmental Laboratory (BDL)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Persons with Alzheimer’s disease and related dementia (ADRD) are among the most adversely affected individuals by the Covid-19 pandemic. Findings from the study will inform health policies and interventionprograms aimed at improving healthcare systems to mitigate adverse effects of the pandemic and reduce healthcare disparities among adults with ADRD. 1

PI_NAMEs: CHOI, HWAJUNG  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Address;Admission activity;Adult;Adverse effects;Affect;Alzheimer's disease related dementia;Area;care systems;Caring;Cognitive;cognitive function;County;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 patient;COVID-19 vaccination;Data;Dementia;disparity reduction;Distance Learning;Economics;ethnic minority;Ethnic Origin;Event;experience;Exposure to;Family;Family member;Gender;Geographic Locations;Geography;Grain;Health;Health Care Costs;health care disparity;health care service utilization;health difference;Health Policy;Healthcare;Healthcare Systems;Home Care Services;Home Nursing Care;Hospitalization;Hospitals;improved;in-home care;Individual;infection rate;infection risk;informal care;innovation;insight;intervention program;Job loss;long term COVID-19 pandemic impacts;Measures;Mediating;mortality;Nursing Homes;Outcome;pandemic disease;pandemic impact;Persons;Physical Function;Policies;pre-pandemic;primary caregiver;Race;racial minority;Resources;Risk;Role;social;sociodemographics;socioeconomics;Time;Variant;Virus;Virus Diseases;Vulnerable Populations

PROJECT_TITLE: The effects of the Covid-19 pandemic on formal and informal care among adults with dementia

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project narrative This project develops statistical foundations necessary for understanding how the interaction of sketching techniques and molecular evolution affects the accuracy of commonly used algorithms for sequencing data. These foundations allow us to quantify uncertainty when studying communities of microorganisms and both identify the taxa present in biological samples and identify samples that possess a large fraction of novel genetic material. We also develop new functionality that captures uncertainty in sequence alignment, one of the most ubiquitous computational techniques in biomedicine.

PI_NAMEs: BLANCA PIMENTEL, ANTONIO ;KOSLICKI, DAVID ;MEDVEDEV, PAUL  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TITLE: Leveraging k-mer sketching statistics to enhance metagenomic methods and alignment algorithms

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Patient Safety

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: His-Bundle Corrective Pacing in Heart Failure Heart failure patients with right bundle branch block (RBBB) ECG morphology have been shown to have a suboptimal response to biventricular cardiac resynchronization therapy (BIV-CRT), necessitating the identification of improved treatment strategies. His-bundle corrective pacing for cardiac resynchronization therapy (His-CRT) is an emerging innovative technology that provides more physiologic resynchronization than BIV-CRT, and could better treat patients with RBBB. In this randomized clinical trial, we will prospectively evaluate the efficacy and the mechanism of benefit of His-CRT vs. BIV-CRT by evaluating changes in ECG biomarkers, NT-proBNP, and echo biomarkers at 6 months, and by assessing the temporal changes in ECG biomarkers, NT- proBNP, functional status and quality of life at 6, 12, and 24 months of follow-up in 120 HF patients with right bundle branch block (RBBB) ECG morphology.

PI_NAMEs: TUNG, RODERICK ;VALENTINA KUTYIFA, VALENTINA KUTYIFA VALENTINA KUTYIFA (contact)

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: Aleurites;arm;biological development;Biological Markers;Biological Process;Bundle-Branch Block;cardiac pacing;cardiac resynchronization therapy;Cessation of life;Chicago;Chronic;Clinical;Clinical Trials;cost;Data;Defibrillators;Devices;Doctor of Philosophy;Echocardiography;efficacy evaluation;EFRAC;Electrocardiogram;Electrophysiology (science);Eligibility Determination;Emerging Technologies;Evaluation;Event;experience;follow-up;functional status;Health;Health Care Costs;Heart;Heart failure;Hospitalization;Implant;implantable device;implantation;Implantation procedure;improved;improved outcome;innovative technologies;Laboratories;Lead;Left;Left Ventricular Ejection Fraction;Left Ventricular Function;Length of Stay;Link;Mechanics;Medical center;Morphology;mortality;Mosses;new technology;novel;Outcome;Pathologic;patient subsets;Patients;Pattern;persistent symptom;Physiological;pro-brain natriuretic peptide (1-76);prospective;Quality of life;Randomized;randomized, clinical trials;Records;Research Infrastructure;response;safety assessment;Serious Adverse Event;Serum;standard of care;study population;System;Time;treatment arm;treatment strategy;Universities;Ventricular

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Prevention;Women's Health Research

PI_NAMEs: HOOFNAGLE, ANDREW N (contact)

PROJECT_TERMS: Area;Benign;biobank;Biological Assay;Biological Markers;biomarker discovery;biomarker validation;Biopsy;Blinded;Blood;Blood specimen;Blood Tests;Breast;Breast biopsy;Breast Cancer Early Detection;Breast Diseases;cancer biomarkers;cancer invasiveness;candidate marker;case control;Characteristics;CLIA certified;Clinical;Clinical Chemistry;Collaborations;Collection;Complement;Development;Digestion;early detection biomarkers;Early Detection Research Network;Early Diagnosis;Environment;Enzyme-Linked Immunosorbent Assay;ERBB2 gene;Evaluation;Evaluation Studies;experience;Flow Cytometry;follow-up;Goals;Guidelines;high risk;Human;improved;instrumentation;Laboratories;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mammographic screening;Mammography;manufacturing run;Mass Spectrum Analysis;Medicine;Methods;multiple reaction monitoring;multiplex assay;Mus;next generation sequencing;novel;novel marker;Pathologic;Patient Selection;Patient-derived xenograft models of breast cancer;Patients;Phase;Plasma;Plasma Proteins;pre-clinical;Preparation;Procedures;prospective;protein biomarkers;Proteins;Qualifying;quality assurance;Quality Control;Reagent;Regulation;repository;Reproducibility;Research Design;sample collection;Sampling;Selection Bias;Services;Specificity;support network;Target Populations;Technology;Testing;Thyroglobulin;Translating;United States;Validation;validation studies;Variant;Woman

PROJECT_TITLE: Core - Biomarker Reference Laboratory


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative  Pancreatic cancer is one of the most deadly forms of cancer with a five-year survival of only ~9% and is predicted to be the second most common cause of cancer death by 2025. New treatment strategies are desperately needed to improve outcomes for one of the most treatment resistant human malignancies.

PI_NAMEs: KINSEY, CONAN  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: advanced pancreatic cancer;antitumor effect;aurora kinase A;Autophagocytosis;Back;Basic Science;Biochemical Process;Biochemistry;Biology;biomarker identification;Biopsy Specimen;Bromodomain;Bypass;c-myc Genes;Cancer Biology;cancer cell;Cancer cell line;Cancer Etiology;cancer initiation;career;CDK4 gene;Cell Cycle;Cell Line;Cells;Cellular Assay;Cellular biology;Cellular Metabolic Process;Cessation of life;chemotherapy;Chloroquine;Clinical;clinical investigation;clinical practice;Clinical Trials;Collaborations;Combination Drug Therapy;Combined Modality Therapy;comparative;CRISPR/Cas technology;cytotoxic;Cytotoxic Chemotherapy;cytotoxicity;Data;design;Disease;Doctor of Philosophy;Drug Combinations;Drug resistance;drug sensitivity;Early Diagnosis;Ectopic Expression;efficacy evaluation;Environment;FDA approved;Genetic;genetic analysis;genetic manipulation;Goals;Grant;Growth;Human;Hydroxychloroquine;improved outcome;In Vitro;in vivo;inhibitor;Investigation;knock-down;Knowledge;KRAS2 gene;Laboratories;Laboratory Personnel;Lead;Left;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Mediator;Medicine;MEKs;Mentors;Metabolism;Mitogen-Activated Protein Kinases;Mus;Mutation;Nature;next generation;novel therapeutic intervention;Oncologist;Operative Surgical Procedures;overexpression;Pancreatic Adenocarcinoma;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;pancreatic PDX models;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Phase;Phase I/II Clinical Trial;Phosphotransferases;Physicians;Play;pre-clinical;Pre-Clinical Model;pre-clinical research;Precision therapeutics;predictive marker;Prevention;Process;Proteins;Publications;Publishing;Ras Signaling Pathway;Recycling;Reporter;Research;Resistance;resistance mechanism;Resources;response;Retinoblastoma Genes;Role;Scientist;Secure;Signal Transduction;standard of care;STK11 gene;System;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Toxic effect;Training;Translational Research;Translations;tumor;Tumor Burden;Tumor Markers;tumor metabolism;Tumor Tissue;tumor xenograft;tumorigenesis;Update;Work;Writing;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Resistance Mechanisms to Combined Trametinib and 4-aminoquinolones in the Inhibition of Pancreatic Cancer


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Microbiome;Nutrition;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative: Children who are HIV-exposed uninfected (HEU), i.e. children who do not acquire HIV infection despite HIV infection in their mothers, have a higher risk of mortality, infectious morbidity, and growth deficits than children who are HIV-unexposed uninfected (HUU). We propose to conduct a randomized trial of an intervention which combines human milk oligosaccharides and probiotics in breast-fed HEU infants in South Africa. The aim is to determine whether this intervention can reduce the excess infectious morbidity and growth faltering risks observed in HEU infants.

PI_NAMEs: SHIVAKOTI, RUPAK  (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Address;adverse outcome;Africa South of the Sahara;Age;antiretroviral therapy;Area;arm;Biological;Biological Factors;Breast Feeding;Breastfed infant;Child;child bearing;Clinical;cohort;comparison group;Counseling;Death Rate;Disparity;experience;Fermentation;follow-up;Growth;gut microbiota;Health;health disparity;High Prevalence;high risk;HIV;HIV Infections;HIV-exposed uninfected infant;Human Milk;human milk oligosaccharides;improved;Infant;infant gut microbiome;infant outcome;Inflammation;Inflammatory;inflammatory marker;Intervention;Intervention Trial;Investigation;Lead;manufacture;Mediating;Metabolic Pathway;Metabolism;microbiome;microbiome composition;microbiota;microbiota composition;Morbidity - disease rate;mortality;mortality risk;Mothers;novel;Observational Study;optimism;Outcome;pandemic disease;Pathway interactions;Pharmaceutical Preparations;Placebos;Population;Prevalence;prevent;Probiotics;Randomized;randomized placebo controlled trial;randomized trial;recruit;Research;Research Personnel;Risk;Rural;rural South Africa;Sampling;social factors;socioeconomics;South Africa;success;Testing;Time;transmission process;Vertical Transmission;Visit;Volatile Fatty Acids;Woman

PROJECT_TITLE: Trial of Human Milk Oligosaccharide-based synbiotics for HIV-exposed uninfected children

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATHENS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: The Role of Fathering in the Language Development Among Young, Low-Income African American and Latino Children Project Narrative  Recent studies of low-income children have revealed significant variations in the quality of parent-child communication as well as the quantity of parent input is important for successful child language development. However, the majority of this research has focused on mothers, and more research with ethnic minority fathers is critical for the development of preventive interventions to support language development and early academic success. In this study, we will use video-recorded data from an existing study to refine a rating system to capture characteristics of the father-child joint engagement in a sample of low-income African American and Latino fathers and their young children to examine relations between the quality of the father-child joint engagement and language input and later child language development and school readiness using data already being collected as part of the parent longitudinal study.

PI_NAMEs: CAUGHY, MARGARET O (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: 3 year old;Academic achievement;Achievement;African American;Archives;Area;Behavior;Brain;Characteristics;Child;Child Language;Child Rearing;Child Support;cost;Data;Development;Disparity;disparity elimination;early childhood;early experience;Ecology;Education;elementary school;Environment;ethnic difference;ethnic minority;Ethnic Population;executive function;experience;Failure;Family;father child interaction;father role;Fathers;Fostering;Foundations;Gender;gender difference;Health;Hearing;Heterogeneity;Home;Household;Immigrant;innovation;Intelligence;Investments;joint attention;Joints;Language;Language Development;language outcome;Latino;Latino Population;literacy;Longitudinal Studies;Low income;mathematical ability;Measures;Mediating;Medical;Mexican;minority children;Mother-Child Relations;Mothers;National Institute of Child Health and Human Development;parent-child communication;Parents;Pattern;peer;Poverty;preventive intervention;racial diversity;racial population;Readiness;Reading;reading ability;Research;Sampling;Schools;skills;Spanish;Speech;success;System;Time;Variant;verbal;Video Recording;Vocabulary

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Nanotechnology

ORG_CITY: LANCASTER

ORG_NAME: LYNTHERA CORPORATION

ORG_STATE: PA

PHR: PROJECT NARRATIVE Dry eye disease is one of the most common worldwide ophthalmic conditions, affecting at least sixteen million Americans, in addition to millions more undiagnosed cases that will all rise substantially due to the continuing growth of inflammatory disorders and screen time among the population. In this SBIR Phase II project, we propose to continue the successful development of a drug delivery contact lens (DDCL) that administers cyclosporine A (CsA) using a novel formulation of nano-ingredients to resolve key deficiencies of eye drop formulations; for example, limited bioavailability, both from tear wash-out and vehicular compromises required to solubilize the drug ingredient. The Phase II research strategy will culminate in an IND application for clinical study of the DDCL in a human population, while the commercialization strategy's goal is the development of the product for FDA approval in the US, with the support of a licensing agreement and investment from an established industrial partner.

PI_NAMEs: DOMSZY, ROMAN  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Adsorption;Adult;Affect;Age;aged;Agreement;American;Anti-Inflammatory Agents;Antioxidants;aqueous;arm;Artificial Tears;Autoimmune Responses;Biological Availability;bulbar conjunctiva;Cell Density;cell mediated immune response;Characteristics;Chemistry;Clinical Research;Clinical Trials;commercialization;conjunctiva;Contact Lenses;Cornea;Cyclic GMP;Cyclosporine;delivery vehicle;design;Development;Diagnosis;Disease;dosage;Dose;Drainage procedure;Drops;Drug Delivery Systems;drug development;Drug Kinetics;Dry Eye Syndromes;Dryness;Emulsions;Epithelium;Etiology;Eye;eye dryness;Eyedrops;Film;Formulation;Friction;Frustration;Future;Glycocalyx;Glycoproteins;Goals;Goblet Cells;Growth;Homeostasis;Human;Hyaluronic Acid;Hydrogels;hydrophilicity;Hydrophobicity;Hypoxia;Immune response;Immunomodulators;immunomodulatory therapies;improved;In Vitro;in vivo;Industrialization;Inflammation;Inflammatory;innovation;Investigational Drugs;Investigational New Drug Application;Investments;irritation;lens;Licensing;Life;lipophilicity;Lubrication;manufacture;Manufacturer;Marketing;Mediation;meter;Methods;migration;Modeling;Mucins;nano;nanoemulsion;nanoformulation;Natural Substance;New Zealand;novel;ocular surface disease;Oryctolagus cuniculus;Oxygen;Patients;Permeability;persistent symptom;Persons;Pharmaceutical Preparations;Phase;Play;Population;pre-Investigational New Drug meeting;Prevalence;Process;product development;Production;Property;Protocols documentation;prototype;reduce symptoms;regenerative;Reporting;Research;residence;response;restoration;Rights;Role;Services;side effect;Silicones;Small Business Innovation Research Grant;Solubility;Source;Surface;Symptoms;T-Lymphocyte;Technology;Therapeutic;therapeutic target;Thinness;Time;tv watching;uptake;Woman;Work

PROJECT_TITLE: Sustained delivery technology for Cyclosporine A in the treatment of autoimmune response


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will systematically characterize a novel regulatory pathway that drives breast cancer metastasis. We have revealed that this pathway, mediated by a non-canonical function of the RNA-binding protein SNRPA1, drives a pro-metastatic splicing program.

PI_NAMEs: GOODARZI, HANI  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Address;Alternative Splicing;Awareness;Binding;Binding Sites;Biochemical;Bioinformatics;Biological Assay;Biology;breast cancer metastasis;Breast Cancer Patient;breast cancer progression;cancer cell;Clinical;clinically relevant;Code;Collaborations;Communities;Complex;Comprehensive Cancer Center;Computational Biology;computer framework;Dissection;Elements;Enhancers;Event;Exons;experimental study;Family;Genetic Transcription;Genomics;Goals;Human;in silico;In Vitro;in vivo;innovation;interdisciplinary approach;knock-down;Knowledge;lung colonization;Malignant Neoplasms;Measurement;Mediating;Messenger RNA;Metastatic breast cancer;Methodology;Modeling;Molecular;mouse model;Mus;Mutation;Neoplasm Metastasis;Nonmetastatic;novel;overexpression;Pathologic;Pathway interactions;patient derived xenograft model;Patients;Positioning Attribute;Post-Transcriptional Regulation;programs;promoter;Protein Isoforms;Public Health;Regulation;Regulatory Element;Regulatory Pathway;Regulon;Reporter;Research;RNA;RNA Processing;RNA Sequences;RNA Splicing;RNA-Binding Proteins;Role;Sampling;shape analysis;Small Nuclear Ribonucleoproteins;Structure;Survival Analysis;targeted treatment;Trans-Splicing;Transcript;tumor progression;tumorigenesis;Up-Regulation;Work;Xenograft procedure

PROJECT_TITLE: The RNA structural code underlying pathological regulation of RNA splicing in metastasis

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Primary Health Care;Rural Health

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE This project will consist of two complementary studies at diverse urban, suburban, and rural primary care practices within Central Indiana and South Florida. The first study Aim will evaluate the predictive performance of the Passive Digital Marker, the Quick Dementia Rating Scale (QDRS) using Patient-reported Outcome (PRO) data embedded within the Electronic Health Records, and the combined approach (Passive + QDRS) in the early detection of Alzheimer’s disease and related dementia (ADRD), compared to the gold standard of diagnoses. The second study Aim will evaluate the practical utility and effect of the Passive Digital Marker, the QDRS, and the combined methods in improving the annual rate of new documented ADRD diagnosis in primary care practices. The project will compare different approaches to early detection of ADRD, crucial to the endeavors to stop dementia progression; it will also evaluate the low-cost combined methods and integrated approach to overcome current barriers to ADRD detection.

PI_NAMEs: BEN-MILED, ZINA ;BOUSTANI, MALAZ  (contact);GALVIN, JAMES E

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;American;Area Under Curve;arm;Assessment tool;Caregivers;Caring;Clinical;Clinical dementia rating scale;Code;cognitive testing;cohort;comparative effectiveness;comparative effectiveness trial;cost;cost effective;Data;Dementia;design;Detection;Development;Diagnosis;diagnosis standard;Diagnostic;digital;Digital biomarker;Disease;early detection biomarkers;Early Diagnosis;effectiveness evaluation;Electronic Health Record;electronic health record system;Florida;Funding;Future;Healthcare Systems;Impaired cognition;improved;Incidence;Indiana;Individual;instrument;Machine Learning;machine learning algorithm;machine learning model;Measures;Medical;Medical Care Costs;Medicare;Methods;Modeling;National Institute on Aging;Nature;older adult;Patient Outcomes Assessments;patient screening;Patients;Performance;Persons;Physicians;primary care clinician;primary care patient;primary care practice;Process;Public Health;Randomized;Recommendation;response;Rural;rural area;Sampling;screening;Screening procedure;Services;Site;societal costs;Staging;suburb;Symptoms;Testing;Therapeutic;Time;tool;Translations;underserved area;United States National Institutes of Health;Universities;Validation;validation studies;wellness visit

PROJECT_TITLE: Digital Detection of Dementia Studies (D cubed Studies).


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Digestive Diseases;Infant Mortality;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Receipt of maternal milk is considered a personalized medicine for preterm infants. Greater understanding is needed on the mechanisms of protection provided by the cellular components involved in promoting infant health. Additionally, it is critical to further understand how the cells in milk are impacted by typical storage and delivery practices in the hospital.

PI_NAMEs: BRIERE, CARRIE-ELLEN  (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Address;Admission activity;Affect;Animal Model;Area;Biological;biological systems;Birth;Body System;Brain;Bronchopulmonary Dysplasia;career;Cell Death;Cell Physiology;Cell Survival;cell type;Cells;Characteristics;Clinical;Clinical Research;cytokine;Cytoprotection;Development;donor milk;Ensure;Epithelial Cell Proliferation;Face;feeding;Fostering;Freezing;Future;Gastrointestinal tract structure;Genes;Goals;Growth;Growth and Development function;Health;Heart;Hospitals;Human Milk;Immune response;Immunologics;Impairment;improved;Infant;Infant Development;Infant Health;Inflammatory;Ingestion;innovation;interest;Intervention;intestinal epithelium;Intestines;Knowledge;Laboratories;laboratory experience;Lactation;late onset sepsis;Life;Ligands;Lung;mammary;meetings;Methods;microbial;Milk;milk expression;Modeling;Mothers;mouse model;Necrotizing Enterocolitis;Neonatal;neonatal care;Neonatal Intensive Care Units;Neurological outcome;Newborn Infant;Organ;organ growth;Outcome;pasteurization;personalized medicine;Physiological;Play;pluripotency;Population;premature;Premature Birth;Premature Infant;programs;Property;protective effect;Refrigeration;regenerative;Research;Research Project Grants;Research Proposals;Research Support;Research Technics;Research Training;Risk;Role;Science;Severities;stem;stem cells;stem-like cell;Supporting Cell;Technical Expertise;tissue culture;Training;Translational Research;Travel;Work

PROJECT_TITLE: Cellular Components of Human Milk: An Examination of Their Role in Infant Health and Development and the Functional Impact of Hospital Storage Practices

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Aging

ORG_CITY: DAVIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative The overall goal of the UC Davis ADAR Scholars Program is to diversify the workforce in aging research by supporting undergraduate competency and completion of MSTEM degrees and increasing the number of diverse students entering graduate study in aging-related MSTEM fields. We have developed a series of activities for underrepresented, socioeconomically disadvantaged, and disabled undergraduates. These activities are designed to help the students develop their scientific identity, kindle interest in aging research, and to facilitate the development of their professional skills in preparation to excel in graduate programs and careers in aging science.

PI_NAMEs: BAAR, KEITH  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Admission activity;Aging;aging related;Area;Awareness;Bachelor's Degree;Biology;Biomedical Research;Calculi;California;career;Chemistry;Communication;Communities;Competence;Data Analyses;design;Development;disabled;disabled students;disadvantaged background;disadvantaged student;Discipline;Doctor of Philosophy;Ensure;experience;Experimental Designs;Fostering;Foundations;Gerontology;Goals;Graduate Degree;graduate school;Institution;interest;matriculation;Measurable;meetings;Mexican Americans;minority student;Native Americans;Oral;Outcome;outreach;Peer Group;Performance;Postbaccalaureate;Preparation;Process;programs;racial minority;recruit;Research;Research Activity;Research Design;Research Personnel;Research Support;Scholars Program;Science;Series;skills;social;Social support;Societies;socioeconomic disadvantage;Source;student participation;student retention;Student Selections;Students;symposium;Training;undergraduate student;Underrepresented Minority;Universities;Work;Writing

PROJECT_TITLE: University of California Davis Advancing Diversity in Aging Research Scholars Program


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHICAGO

ORG_DEPT: UROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative The proposed research investigates molecular events called exitrons that can change the sequence of genes and spark abnormal cancer-causing proteins. Our goals are to understand the role of exitrons in cancer initiation and progression, determine if exitron expression can be used to identify patients who will respond to immune targeted therapies, and ultimately find novel ways in cancer treatments.

PI_NAMEs: YANG, RENDONG  (contact)

PROJECT_TERMS: Affect;Algorithms;Alternative Splicing;Automobile Driving;Basic Science;Benchmarking;Bioinformatics;Cancer Diagnostics;cancer immunotherapy;cancer initiation;cancer therapy;cancer type;Cancer Vaccine Related Development;Cancer Vaccines;checkpoint inhibition;checkpoint therapy;Clinical;clinical biomarkers;clinically relevant;Code;Computational algorithm;computational platform;computerized tools;Computing Methodologies;Data;Dedications;Detection;detection platform;Development;Diagnostic;DNA Sequence Alteration;Event;exome sequencing;exon skipping;Exons;experimental study;Genes;Genetic;genetic immunotherapy;genome-wide;Goals;Human;immune checkpoint blockade;Immune checkpoint inhibitor;Immune Targeting;immunogenic;innovation;insight;Introns;Joints;Knowledge;large datasets;Link;loss of function;Machine Learning;machine learning model;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediator;Meta-Analysis;Molecular;Multiomic Data;multiple omics;Mutate;Mutation;neoantigens;Neoplasm Metastasis;non-genetic;Nonsense-Mediated Decay;novel;novel strategies;Oncogenes;Outcome;Pathway interactions;patient response;Patients;Pattern;Peptides;Post-Translational Modification Site;predicting response;prognostic;protein function;Protein Isoforms;Proteins;Proteomics;Reading Frames;Regulation;Research;Resistance;response;RNA;RNA Degradation;RNA Splicing;Role;Sample Size;Sampling;Sensitivity and Specificity;sequencing platform;simulation;Site;Source;supervised learning;T cell therapy;targeted treatment;Technology;Testing;The Cancer Genome Atlas;Therapeutic;transcriptome;transcriptome sequencing;transcriptomics;Translating;tumor;tumor progression;Tumor Suppressor Genes;tumorigenesis;Variant;Work

PROJECT_TITLE: Genome-wide mapping and characterization of exitrons in human cancer


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse;Telehealth

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The proposed research is of considerable public health significance as it will provide information to facilitate implementation of strategies to bolster retention in and adherence to addiction pharmacotherapy for individuals with opioid use disorders, a disproportionately affected subgroup of substance users for whom overdose fatalities are increasing. The technology-assisted behavioral intervention we propose to study may provide a promising, cost-effective, and easily deployable strategy for the effective treatment of opioid use disorders.

PI_NAMEs: GLASNER, SUZETTE V (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: addiction;Address;Adherence;Adult;Affect;Aftercare;Alcohols;Anti-Retroviral Agents;Behavior Therapy;Behavioral;Behavioral Research;Biochemical;Buprenorphine;buprenorphine treatment;Cellular Phone;Cognitive Therapy;community partners;cost;cost effective;Cost Effectiveness Analysis;Cost Measures;cost-effectiveness evaluation;Coupled;Data;Development;Dropout;Education;Educational Intervention;effective intervention;effective therapy;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness trial;efficacious treatment;Evaluation;experience;family support;Feedback;follow-up;Freedom;Health;Health education;health service use;HIV;implementation facilitation;improved;improved outcome;Individual;innovation;Intervention;Interview;Investigation;low socioeconomic status;Measures;Medical;medication compliance;medication-assisted treatment;mHealth;mhealth interventions;National Institute of Drug Abuse;Notification;novel;Opiate Addiction;opioid epidemic;opioid mortality;opioid overdose;opioid use;opioid use disorder;opioid user;Outcome;overdose death;overdose prevention;overdose risk;Participant;Pharmaceutical Preparations;Pharmacotherapy;Phase;phase 2 study;Population;Preparation;prescription opioid;primary outcome;Process;programs;Protocols documentation;Provider;psychosocial;Public Health;recruit;relapse prevention;relapse risk;Reporting;Research;Research Design;Research Personnel;response;Risk Factors;risk mitigation;Site;skills;social;social interventions;standard care;Subgroup;Substance Use Disorder;substance user;System;Technology;Testing;Text Messaging;tool;treatment adherence;usability;user-friendly

PROJECT_TITLE: Effectiveness of a CBT-based mHealth Intervention Targeting MOUD Retention, Adherence, and Opioid Use

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: STANFORD

ORG_DEPT: SURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE This proposed Functional Characterization Center will provide important new insights into the regulatory wiring of the human genome. We will utilize scalable genome engineering technologies to build comprehensive maps that describe how genetic elements and sequence changes control our genes and cells. This work will be crucial to understanding the genetic basis of many common human diseases.

PI_NAMEs: ENGREITZ, JESSE M (contact);QUERTERMOUS, THOMAS

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Adult;Affect;Biological;Biological Assay;Biological Models;Biology;Calibration;candidate identification;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Catalogs;causal variant;Cell Differentiation process;Cell Physiology;cell type;Cells;Child;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;Computer Models;Computer software;CRISPR interference;CRISPR screen;CRISPR/Cas technology;Data;Data Set;data sharing;design;Development;Disease;disease model;Disease Pathway;disorder risk;DNA;Elements;Endothelial Cells;Enhancers;Evaluation;experimental study;functional genomics;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic element;Genetic Transcription;genetic variant;Genome;Genome engineering;genome wide association study;genomic tools;genomic variation;Heart Diseases;Human;human disease;Human Genetics;Human Genome;human pluripotent stem cell;improved;in vivo;innovation;innovative technologies;insight;Learning;Logic;Macrophage;Maps;Measures;Methods;Modeling;Molecular;Mus;Mutagenesis;National Human Genome Research Institute;new technology;novel strategies;Nucleotides;Phenotype;predictive modeling;prime editing;Printing;promoter;Protocols documentation;Regulatory Element;risk variant;RNA;single cell ATAC-seq;Smooth Muscle Myocytes;Surveys;Technology;Testing;Tissues;tool;trait;Universities;Untranslated RNA;Variant;Work

PROJECT_TITLE: Stanford Center for Connecting DNA Variants to Function and Phenotype