ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Hematology

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Inflammation due to infection and tissue damage causes anemia because inflammation inhibits the production new red blood cells by the bone marrow. To compensate for this loss of red blood cell production, the body induces a stress response to rapidly make new red blood cells. This proposal will examine the mechanisms by which this stress pathway makes new red blood cells with the hope that these studies will identify new therapies for anemia.

PI_NAMEs: PAULSON, ROBERT FRANK (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Adopted;Affect;amino acid metabolism;Amino Acid Transporter;Amino Acids;aminoacid biosynthesis;Anabolism;Anemia;Anemia due to Chronic Disorder;beta catenin;biological adaptation to stress;blood glucose regulation;Bolus Infusion;Bone Marrow;Carbon;Cell Proliferation;Compensation;Coupled;critical period;Data;Defect;design;dimer;Enzymes;Erythrocytes;Erythroid;erythroid differentiation;Erythroid Progenitor Cells;Erythropoiesis;Erythropoietin;Fructose;GDF15 gene;Generations;Glutamine;Glycine;Glycolysis;Health;Hematopoiesis;Hemolytic Anemia;Homeostasis;Human;Infection;Inflammation;Inflammatory;inorganic phosphate;Iron deficiency anemia;Lipids;macromolecule;Metabolic;Metabolism;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;Myeloid Cells;Myelopoiesis;Nitric Oxide;novel therapeutics;Nucleotides;Output;Pathway interactions;Pentosephosphate Pathway;Phosphotransferases;Population;Process;Production;progenitor;Proliferating;purine metabolism;Purines;Pyruvate Kinase;Quality of life;Recovery;Red Blood Cell Count;Regulation;Role;Serine;Signal Pathway;Signal Transduction;Source;stem cell differentiation;stem cell population;stem cells;Stress;Supporting Cell;System;Text;Thalassemia;tissue regeneration;Tissues;transcription factor;Translations;uptake;WNT Signaling Pathway;Work

PROJECT_TITLE: Metabolic Regulation of erythropoiesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Natural Products;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: HONOLULU

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: Project Narrative Taking advantage of Hawaii’s unique multiethnic population with cancer health disparities and a unique physical environment for drug discovery, this training program will mentor undergraduate and graduate students living in Hawaii and in the Pacific by providing them with distinctive training experiences both in cancer biology and in population sciences. This hands-on cancer research experience will enable trainees to pursue successful careers in cancer prevention and control that will help to lower cancer incidence and mortality.

PI_NAMEs: KAHOLOKULA, JOSEPH KEAWE'AIMOKU;LOO, LENORA WM;MASKARINEC, GERTRAUD  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;anti-cancer research;Behavioral Research;Biochemical;Biological;Biological Assay;Biological Products;Biomedical Research;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;cancer prevention;cancer therapy;career;career development;Characteristics;Chinese;Clinical Research;Collaborations;Colorectal Cancer;Community Outreach;Diagnosis;Discipline;drug development;drug discovery;Education;education planning;education research;Educational Activities;Educational Curriculum;Educational workshop;Electronic Mail;eligible participant;empowerment;Environment;Ethnic Origin;Ethnic Population;European;European ancestry;experience;Faculty;field study;Filipino;Filipino American;Funding;Future;Goals;graduate student;Guam;hands on research;Hawaii;health disparity;High School Student;improved;Incidence;Individual;Interdisciplinary Study;Invaded;Island;Japanese;Japanese American;Koreans;low socioeconomic status;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of pharynx;Malignant neoplasm of prostate;Malignant neoplasm of thyroid;Malignant Neoplasms;malignant stomach neoplasm;medical schools;member;Mentors;Mission;mortality;multi-ethnic;multidisciplinary;Native Hawaiian;Native-Born;Natural Compound;Natural Product Drug;Natural Products;NCI Center for Cancer Research;next generation;novel;Oral cavity;Organism;Oropharyngeal;Pacific Islander;Participant;Patient Care;Philanthropic Fund;Physical environment;Polynesian;Population;Population Sciences;prevent;Prevention;Preventive;Process;Professional Organizations;programs;Qualifying;recruit;Research;research faculty;Research Personnel;Research Training;Resources;Running;Science;skills;small molecule;social media;Students;success;summer internship;summer research;Surveys;System;Talents;Training;Training Programs;tumor initiation;undergraduate student;United States;Universities

PROJECT_TITLE: Cancer Research Education, Advancement, Training and Empowerment (CREATE) in the Pacific

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Mental Health;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: EDINBURG

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

ORG_STATE: TX

PHR: PROJECT NARRATIVE Exposure to psychosocial stressors is associated with negative health outcomes, including excessive activity of the sympathetic nervous system that may lead to cardiovascular problems. This proposal investigates arginine- vasopressin modulation of the ventral midbrain and responses to psychosocial stressors that are risk factors for developing cardiovascular disease. The proposed study is relevant to public health because it explores the therapeutic potential of arginine-vasopressin, acting via the V1A receptor, in treating psychosocial stress- associated cardiovascular conditions.

PI_NAMEs: GIL, MARIO  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Acute;Acute myocardial infarction;acute stress;Address;Aggressive behavior;alternative treatment;Animal Model;Animals;Antipsychotic Agents;Anxiety;Area;Argipressin;behavioral response;Biological;biological adaptation to stress;Blood;Brain;brain tissue;Cannulas;Cardiac;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;career development;Catecholamines;Cause of Death;Cerebrovascular Disorders;Cessation of life;Collection;Communities;Coronary Arteriosclerosis;Coronary heart disease;Data;Disease Outcome;disorder risk;Emotional;emotional distress;Emotional Stress;Endocrine;Epidemiology;Event;experience;Exposure to;Fiber;gene environment interaction;Gene Expression;Gene Expression Profile;Genes;Genetic;Goals;Grant;Health;Health Promotion;Heart;Heart Diseases;Heart failure;heart function;Heart Injuries;Housing;Human;Hypothalamic structure;implantation;improved;improved outcome;Individual;Infarction;Injury;Knowledge;Learning;Link;Mentorship;Mesocricetus auratus;Microinjections;Midbrain structure;Modeling;Muscle Cells;Myocardial Infarction;myocardial injury;Myocardial Ischemia;Myocardial Reperfusion Injury;neural;neuromechanism;Neurons;Neuropeptides;Neurosecretory Systems;novel;Odds Ratio;Outcome;Pathway interactions;Patients;Personal Satisfaction;Personality Traits;Physiological;Play;predicting response;Predisposition;Program Development;programs;Property;psychological distress;psychosocial;Psychosocial Stress;psychosocial stressors;Public Health;receptor;Receptor Gene;Reperfusion Injury;Research;Research Personnel;response;Reverse Transcriptase Polymerase Chain Reaction;Risk Factors;Role;Saline;Sex Differences;Signal Transduction;skills;Social isolation;Stress;Stress cardiomyopathy;stress management;stress related disorder;stressor;Stroke;sudden cardiac death;Surgical Injuries;Sympathetic Nervous System;Syndrome;Testing;Therapeutic;Translating;United States;V1a vasopressin receptor;Ventral Tegmental Area;Ventricular;Work;Writing

PROJECT_TITLE: Role of arginine-vasopressin and V1A receptor in psychosocial stress-induced myocardial injury


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hearing Loss;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: WORCESTER

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE The U.S. Deaf community – a group of more than 500,000 Americans who communicate using American Sign Language (ASL) – experiences nearly triple the rate of lifetime problem drinking and twice the rate of trauma exposure compared to the general population. Although there are several treatments for alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) in hearing populations, none have been developed for or tested with Deaf clients. To address these barriers, our team developed Signs of Safety, a Deaf-accessible therapy toolkit for treating AUD and PTSD. We propose a nationwide, virtual clinical trial to compare (1) Signs of Safety with (2) treatment as usual and (3) a no treatment control, to collect data on clinical outcomes, and to explore potential mediators and moderators of outcome.

PI_NAMEs: ANDERSON, MELISSA LEE (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Acceleration;addiction;Address;Adult;Aftercare;Alcohol abuse;alcohol abuse therapy;alcohol comorbidity;Alcohol consumption;alcohol use disorder;Alcohols;American;American Sign Language;arm;artist;Back;behavioral health;Client;Clinical;Clinical Trials;Cognitive;Cognitive Therapy;Collaborations;Communication;Communities;community engagement;coping;Coping Skills;Counseling;COVID-19 pandemic;Data;deaf;Development;Disparity;DSM-V;Education;Educational process of instructing;emotional abuse;Employment;Enrollment;evidence base;Evidence based treatment;experience;falls;Feasibility Studies;feasibility testing;Film;follow-up;Foundations;fourth grade;Frequencies;functional outcomes;Future;General Population;Health;Hearing;Immigrant;Impairment;indexing;Individual;Infrastructure;Intervention;Language;literacy;Literature;Manuals;Mediator;Mental Health;Mental Health Services;Methods;Motivation;Outcome;Participant;Persons;physical abuse;physical conditioning;pilot test;Population;Post-Traumatic Stress Disorders;Problem Solving;programs;Protocols documentation;Provider;psychoeducation;Psychotherapy;Randomized;recruit;Reporting;Research;Research Personnel;Resources;response;Safety;Self Efficacy;self-compassion;Services;Severities;Sexual abuse;Sign Language;Socialization;Testing;Text;timeline;Translations;Trauma;trauma exposure;treatment as usual;Treatment Protocols;treatment research;trial comparing;verbal;virtual;virtual clinical trial;virtual platform;Visual;Vocabulary;Waiting Lists;Work;Writing

PROJECT_TITLE: Evaluating Signs of Safety: A Deaf-Accessible Therapy Toolkit for AUD and Trauma

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: GM

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: COLLEGE STATION

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PUBLIC HEALTH RELEVANCE STATEMENT (PROJECT NARRATIVE) The proposed research is relevant to public health and the NIH’s mission of developing fundamental knowledge and therapeutics that will help reduce the enormous burdens of morbidity and mortality associated with human disease. The goal of this project is to develop new classes of engineered antibodies that can be precisely controlled to regulate cellular physiology. These smart antibodies can be used not only as broadly-applicable biomedical research tools, but also as potential precision therapeutics to intervene in human diseases, including cancer and neurodegenerative disorders.

PI_NAMEs: ZHOU, YUBIN  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Acute;Address;Alzheimer's disease model;Amyloid beta-42;Animals;Anti-viral Agents;Antibodies;antibody engineering;antibody mimetics;Antigens;Beverages;Biological;Biological Assay;Biological Models;Biological Process;biological systems;Biomedical Research;Biophysics;Caffeine;case-by-case basis;Cell Physiology;Cells;Cellular biology;Chemicals;chimeric antigen receptor T cells;clinically relevant;cofactor;Complement;Consumption;Cues;Data;design;Development;Drosophila genus;Engineering;FDA approved;Future;Generations;Genetic;genetic approach;Genome engineering;Goals;Hepatitis C virus;Heterodimerization;high throughput screening;human disease;human model;Huntington Disease;Huntington gene;Immunotherapy;improved;in vivo;in vivo Model;innovation;interest;Invaded;Kinetics;Knock-in;Knowledge;Light;Malignant Neoplasms;Methods;Mission;Modality;Modeling;Molecular;molecular imaging;Molecular Immunology;Morbidity - disease rate;mortality;mutant;Names;nano;nanobodies;nanoparticle;Nerve Degeneration;Neurodegenerative Disorders;neuroregulation;neurotoxic;novel;novel strategies;optogenetics;Organism;Pathway interactions;Penetration;Peptide Hydrolases;Pharmaceutical Preparations;photoactivation;Photons;Precision therapeutics;Process;Property;Protein Engineering;protein protein interaction;Proteins;Public Health;public health relevance;Publications;remote control;Research;research and development;Resolution;Resources;Rodent;Rodent Model;Scaffolding Protein;Scheme;structural biology;synthetic biology;System;Technology;Testing;theranostics;Therapeutic;Time;timeline;Tissues;tool;Transducers;translational applications;translational barrier;Tumor Immunity;tumor immunology;United States National Institutes of Health;Viral;Visualization;wireless

PROJECT_TITLE: Engineering Smart Antibody-like Protein Scaffolds with precision switches

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Cancer;Contraception/Reproduction;Infertility;Organ Transplantation;Pediatric;Regenerative Medicine;Transplantation;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Life-saving treatments for cancer have significantly improved survival rates in recent decades, particularly among those affected in childhood, however, many of these therapies have a deleterious impact on the gonad and are a major cause of infertility and early menopause in female cancer survivors. For pre-pubescent girls that are incapable of responding to ovarian stimulation, cryopreservation of ovarian tissue has emerged as an effective means of safeguarding reproductive options, but auto-transplantation of tissue back into patients following remission is highly inefficient and results in poor oocyte yields. Using a combination of patient-derived vascular endothelial cells and robust local delivery of an ovary-specific factor, anti-Müllerian hormone, via modified mRNA, this proposal aims to both improve the viability and output of thawed ovarian tissue following auto-transplantation and/or protect the ovary in situ from the gonadotoxic influence of cancer chemotherapy.

PI_NAMEs: JAMES, DAYLON J (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Acceleration;Acute;Address;Affect;Age;Autologous;Autologous Transplantation;Back;Birth Rate;Blood Vessels;cancer cell;Cancer Survivor;cancer therapy;cell injury;Cell Separation;Cells;chemotherapeutic agent;chemotherapy;Chemotherapy-Oncologic Procedure;Childhood;Chronic;Cortex of ovary;Counseling;Cryopreservation;Cryopreserved Tissue;Disease;Disease remission;Engraftment;Environment;Equilibrium;Excision;experimental study;Female;fertility preservation;Foundations;Freezing;Frequencies;Future;Gene Expression;girls;Goals;Gonadal structure;graft function;Graft Survival;Growth;healthcare burden;Hematologic Neoplasms;Homeostasis;Hormone use;Human;Iatrogenesis;improved;improved outcome;In Situ;Infertility;Inflammatory;inflammatory milieu;Ischemia;Life;Live Birth;Malignant Neoplasms;Measures;Mediating;Menopause;Messenger RNA;Methods;Molecular;Monitor;Morbidity - disease rate;mortality;mullerian-inhibiting hormone;Mus;Newly Diagnosed;Oocytes;Outcome;Output;Ovarian;Ovarian Hyperstimulation Syndrome;ovarian reserve;Ovarian Stimulations;Ovarian Tissue;Ovarian tissue cryopreservation;Ovary;ovary transplantation;Pain;Pathologic;patient population;Patient risk;Patients;Perfusion;Phase;Physiology;post-transplant;preconditioning;premature;Premature Menopause;Premature Ovarian Failure;prepuberty;preservation;Primordial Follicle;Production;Productivity;protective effect;Proteins;Quality of life;Recombinants;repository;Repression;reproductive;Resistance;restoration;Risk;Services;side effect;Signal Transduction;Site;Source;stem;Stimulus;Survival Rate;Survivors;Techniques;Technology;Therapeutic;Time;Tissue Grafts;tissue processing;Tissue Transplantation;Tissue Viability;Tissues;Transplant Recipients;Transplantation;Uncertainty;Vascular Endothelial Cell;Woman;women patients;Work;Xenograft procedure;young woman

PROJECT_TITLE: Anti-Mullerian hormone for preserving ovarian function before administration of gonadotoxic therapies or after transplantation of cryopreserved tissue.

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Suicide rates among U.S. Hispanics have increased by approximately 20% since 2000 and the Hispanic population is expected to double in the coming decades, indicating that suicide among Hispanics is an issue of pressing public health concern. However, empirical data indicating how to prevent suicide among this population, especially for Spanish-speaking adults in the U.S., are notably lacking. This proposal forms the basis of a program of research focused on suicide prevention for geographically and linguistically isolated Hispanics, with a particular emphasis on the role of cultural-social engagement in the prevention of suicide among this population.

PI_NAMEs: SILVA, CAROLINE  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Adolescent;Adult;Aftercare;attenuation;Behavior Therapy;Behavioral;career development;Cellular Phone;Cessation of life;Clinical;Clinical Trials;Cognitive;Communities;Coupled;cultural values;Data;Development;Ecological momentary assessment;Elements;Ethics;ethnic minority population;Event;Evidence based intervention;Expectancy;Family;Feedback;Feeling;Feeling suicidal;follow-up;Friends;Funding;Geography;Goals;health determinants;Hispanic;hispanic community;Hispanic Populations;Home;human centered design;ideation;improved;in vivo;Individual;innovation;interest;Intervention;Interview;Investigational Therapies;Language;Linguistics;Link;Location;Measures;Mental Depression;Mental Health;Mentors;Methodology;Monitor;National Institute of Mental Health;Nature;novel;Outcome;Outpatients;Participant;Patient Self-Report;Perception;Population;post intervention;Prevention program;Prevention Research;preventive intervention;programs;protective factors;psychologic;Public Health;racial minority population;Randomized;randomized, clinical trials;Randomized, Controlled Trials;rapid growth;reducing suicide;Religiosity;Reporting;Research;Research Project Grants;research study;Risk;Role;Sampling;Severities;skill acquisition;social;Social Behavior;social culture;social engagement;social factors;Social Interaction;Spanish;Structure;suicidal risk;Suicide;Suicide prevention;suicide rate;Techniques;Technology;Testing;theories;Therapeutic;Time;Training;Treatment Protocols;Underserved Population;United States;usability;Visit;Well in self;Work

PROJECT_TITLE: Cultural-Social Engagement and Suicideamong Hispanics

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Narrative Advances in non-invasive monitoring of human brain function under normal and pathological conditions will lead to breakthroughs in our understanding of the brain in health and disease, and lead to the development of devices available for everyday use, with applications such as monitoring patients with brain injuries or neurodegenerative disease, studies of brain function in natural environments, and brain-computer interfaces. We propose to develop a fiber-based speckle contrast optical spectroscopy (SCOS) system to measure CBF variations due to brain activation in humans with a contrast to noise ratio (CNR) by at least one order of magnitude compared with existing systems, that will also measure all the hemodynamic parameters associated with brain activation, achieve an up to 3x improvement in brain sensitivity compared with traditional optical brain imaging devices, and permit estimation of evoked changes in CMRO2. This will provide a unique neuroimaging approach to measure all cerebral hemodynamic and optical metabolism parameters related to brain function.

PI_NAMEs: BOAS, DAVID A;CHENG, XIAOJUN  (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Adoption;Adult;Brain;brain computer interface;Brain imaging;Brain Injuries;cerebral hemodynamics;Cerebrovascular Circulation;Cerebrum;Child;cost;cranium;data analysis pipeline;density;detector;Device or Instrument Development;Diffuse;Disease;Environment;Fiber;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Future;Geometry;Health;hemodynamics;Hemoglobin;Human;Image;Imaging Device;imaging modality;Imaging Techniques;improved;Infant;Measurement;Measures;metabolic rate;Metabolism;metal oxide;Methods;Modeling;Monitor;Motion;Near-Infrared Spectroscopy;Neurodegenerative Disorders;neuroimaging;Noise;non-invasive monitor;novel strategies;Optical Methods;Optics;Oxygen;Pathologic;Patient Monitoring;Pattern;Performance;Phase;Photons;Population;portability;Resolution;response;Semiconductors;Signal Transduction;Source;Specificity;Spectrum Analysis;System;temporal measurement;Time;tomography;tool;Variant;wearable device;Work

PROJECT_TITLE: A transformative method for functional brain imaging with Speckle Contrast Optical Spectroscopy


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Some children who are born very early develop severe, long-term lung problems that make them need a breathing machine to live at home and there are no studies that explain why some children need to use a breathing machine longer than others. This research will provide new understanding about why a given child may, in the context of their family and the care they receive, use a breathing machine longer, have to go the emergency room more often, and be hospitalized more often than another child. This research will also test whether providing more complete information to a child’s team of doctors, nurses, and respiratory therapists about the factors that affect how long children use breathing machines at home, can safely decrease the time a child uses a breathing machine while also avoiding hospitalization.

PI_NAMEs: FOSTER, CAROLYN C. (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Accident and Emergency department;Active Learning;Acute;Affect;Award;Birth;Breathing;Bronchopulmonary Dysplasia;Carbon Dioxide;care burden;care giving burden;career;career development;Caregiver Burden;Caregivers;Caring;Categories;Child;Child Care;Child Health;Chronic lung disease;Clinical;clinical care;Clinical Data;Clinical Investigator;Clinical Management;cost;dashboard;Data;Data Element;Dependence;design;Development Plans;Discipline of Nursing;Educational workshop;Emergency department visit;Enrollment;Environment;Equilibrium;evidence base;experience;Extended Family;Family;Family Caregiver;Family health status;Fatigue;Fostering;Foundations;Frequencies;Funding;Gestational Age;Goals;Growth;Health;Health Benefit;Health Care Costs;health care delivery;health care service utilization;health determinants;Health Services;Health system;Healthcare;Height;Home;home mechanical ventilation;hospital services;Hospitalization;Hospitals;improved;innovation;Institution;intervention delivery;Learning;learning engagement;Life;Logistics;Lung;Measurable;Measurement;Measures;Mechanical ventilation;Medical;Medical Technology;Medicine;Mental Health;Mentors;Mentorship;Methods;Modeling;Monitor;mortality risk;Nurses;Outcome;Outcome Measure;Oxygen;Parents;Patient Outcomes Assessments;patient population;Patients;Pediatric Hospitals;pediatrician;perinatal period;physical conditioning;Physical Function;Physicians;Physiological;pilot test;Population;pressure;Private Duty Nursing;Process;programs;prospective;Provider;Psyche structure;Publishing;Pulmonary Hypertension;Research;Research Infrastructure;Research Personnel;Resources;respiratory;Risk;Safety;Science;Self Efficacy;Services;Severity of illness;sex;skills;Social Environment;Surveys;System;Testing;therapy design;Time;Titrations;Tracheostomy procedure;Training;United States National Institutes of Health;Universities;usability;ventilation;Ventilator;Weaning;Weight;Work

PROJECT_TITLE: HOMeVent4Kids: Home-based Optimization of Mechanical Ventilation for Children

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Cancer;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Infectious Diseases;Racial and Ethnic Minority Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Narrative: White blood cell count (WBC) and neutrophil counts are used in many domains of medicine including as parameters to help dose medications and for criteria in diagnosing and prognosticating in infection. WBC and neutrophil counts are lower among African Americans and other persons of African and/or Middle Eastern ancestry compared to persons of European or East Asian ancestry, and the genotype underlying this observation is well known. We propose to use large datasets with matched genotype and clinical outcomes to determine how to interpret WBC and neutrophil counts for the purpose of dosing medications that affect these counts including chemotherapy and for the purpose of accurately diagnosing severe infections.

PI_NAMEs: ZIV, ELAD  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: accurate diagnosis;Acute;acute infection;Address;Affect;Africa;African;African American;African American population;African ancestry;Alleles;Antigen Receptors;Antigens;Asian ancestry;Bacterial Infections;biobank;cancer recurrence;Caring;chemokine receptor;chemotherapy;Chromosome Mapping;Chronic;Clinical;clinical care;cohort;data integration;Diagnosis;Diagnostic;Disparity;Dose;Dose Limiting;East Asian;electronic health database;Electronic Health Record;Erythrocytes;Ethnic Origin;European;European ancestry;Fever;Frequencies;genetic variant;Genotype;improved;Incidence;Individual;Infection;infection risk;Inflammatory;Knowledge;large datasets;Latino Population;Leukocytes;Link;Lymphocyte Count;Maps;Medical;Medicine;Middle East;Middle Eastern;Monitor;Myelosuppressive Therapy;Neutropenia;neutrophil;Outcome;outcome prediction;patient stratification;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Pneumonia;Population;Process;Prognosis;prognostic;Prognostic Factor;prognostication;Promoter Regions;Race;Research;Risk;risk stratification;Sepsis;Severities;Surface;Testing;Toxic effect;Variant;White Blood Cell Count procedure

PROJECT_TITLE: Evaluating the clinical implications for ACKR1/DARC associated neutropenia

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ORG_CITY: PORTLAND

ORG_NAME: NORTHWEST PORTLAND AREA INDIAN HLTH BD

ORG_STATE: OR

PHR: Project Narrative The Northwest Portland Area Indian Health Board (NPAIHB) has a long-standing health research relationship with Oregon Health & Science University and Portland State University. With its two academic partners, the NPAIHB will implement three training programs for American Indian and Alaska Native researchers designed to help reduce disparities for tribal people nationwide, including a graduate fellowship program in cancer prevention research, a fellowship in applied biostatistics, and our Summer Research Training Institute for AI/AN health professionals…a program that has included over 1000 trainees so far. In addition to the training grants, we will evaluate the feasibility of an elders’ fall intervention program that makes use of technology only available in Portland for balance testing and monitoring.

PI_NAMEs: BECKER, THOMAS MARK (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Academia;Accreditation;Address;Advisory Committees;Alaska Native;Alaska Native population;American Indian Population;American Indians;Area;balance testing;Biomedical Research;Biometry;cancer prevention;Chronic Disease;Collaborations;Communities;community academic partnership;community advisory board;Community Health;community-centered;Data;Data Set;design;Development;disparity reduction;distrust;Educational Grants;Elderly;Equilibrium;evidence base;experience;faculty mentor;Fall prevention;falls;Fellowship;Fellowship Program;follow-up;Fright;Funding;Goals;Grant;Health;Health Alliance;health data;health disparity;Health Priorities;Health Professional;Health Sciences;Health Status;Healthcare;Human Resources;improved;Individual;Infrastructure;Institution;Internet;Intervention;intervention program;Leadership;lectures;member;Mentors;Methods;Modification;Monitor;Native American Research Center for Health;Native-Born;Northwest Tribe;Oregon;Persons;Prevalence;Prevention Research;programs;Qualifying;racial health disparity;Research;Research Personnel;Research Project Grants;Research Support;Research Training;response;Role;Science;skills;Strategic Planning;Students;substance misuse;summer research;Technology;Training;Training Programs;training project;tribal community;Tribal group;tribal health;tribal leader;tribal member;tribal organization;Tribal-academic partnership;Tribes;Trust;United States Indian Health Service;United States National Institutes of Health;Universities;Vocational Guidance

PROJECT_TITLE: Elevating NW Tribal Health Sciences: NW NARCH Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y(55)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Substance Misuse

PROJECT_TERMS: Address;Administrator;American Indian community;Area;Collaborations;Communities;Community Health;design;Development;Electronics;Epidemiology;Evaluation;experience;Faculty;Fall prevention;Funding;Grant;Health;Health Sciences;Investments;Leadership;meetings;member;minority health;Native American Research Center for Health;Newsletter;Oregon;Outcome;Pacific Northwest;Persons;Process;programs;Reporting;Research;Research Personnel;Research Project Grants;Research Training;Resolution;Scientist;Strategic Planning;Students;success;Training;training opportunity;training project;Transplantation;Travel;Tribal group;tribal health;Tribes;United States Indian Health Service;United States National Institutes of Health;Universities;Viral;web site;Work

PROJECT_TITLE: NARCH 11 Admin Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative Organelle contact, including the interactions between mitochondria and endoplasmic reticulum (ER), plays an important role in cell and animal health, and defects in this process are associated with human disorders. We are studying the relationship between the lipid transport protein VPS13D, mitochondria and ER contact, autophagy, cell stress, and inflammation in models of a progressive neurodegenerative disease. The association of defects in organelle contact, autophagy, cell stress, and inflammation with age-associated disorders illustrates the importance of investigating the relationship between these processes and human health.

PI_NAMEs: BAEHRECKE, ERIC H (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Acanthocytosis;Age;age effect;age related;age-related disease;Aging;Alleles;Animals;Ataxia;Autophagocytosis;Behavior;Behavioral;behavioral phenotyping;Brain;Carrier Proteins;Cell Death;Cell Line;Cell Physiology;Cells;Cellular Stress;Child;Chorea;Communication;Complex;conditional knockout;Defect;Disease;disease model;disease phenotype;Drosophila genus;Dystonia;early onset;Embryo;Endoplasmic Reticulum;Exhibits;Failure;Fibroblasts;Genes;Goals;Health;Heat shock proteins;Hippocampus;Histologic;Human;human disease;Impairment;Inflammation;Inflammatory;inflammatory marker;Ions;Knock-out;Knockout Mice;Leigh Disease;Link;lipid transfer protein;lipid transport;Lipids;LoxP-flanked allele;Magnetic Resonance Imaging;Mitochondria;mitochondrial autophagy;Modeling;mouse model;Movement Disorders;Mus;mutant;mutant mouse model;Mutant Strains Mice;Mutation;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;Neurologic Symptoms;neuron loss;Neurons;neuropathology;Organelles;Paraparesis;Paraplegia;Parkinson Disease;Pathway interactions;Patients;pediatric patients;Phenotype;PINK1 gene;Play;postnatal;prevent;Process;Proteins;Recessive Genes;Reporting;Role;Severities;Signal Transduction;spasticity;Stress;Symptoms;Tremor

PROJECT_TITLE: VPS13D, organelle contact, and cellular stress in models of disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-Z(52)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse

PROJECT_TERMS: Address;Affect;Alaska Native;Alaska Native population;American Indian Population;American Indians;anti-cancer research;Applications Grants;Area;Benchmarking;Cancer Burden;Cancer Control;Cancer Control Research;Cancer Etiology;cancer prevention;cancer survival;case-based;Communication Methods;Communities;Consultations;cultural competence;data management;design;Disparity;Distance Learning;Educational Curriculum;Educational workshop;Electronic Mail;Enrollment;Evaluation;Exercise;experience;Faculty;Fellowship;follow-up;Funding;Goals;Grant;Health;Health Sciences;improved;Incidence;Indigenous;innovation;Investments;Language;Malignant Neoplasms;Manuscripts;Measurable;Measures;meetings;member;Mentors;mortality;Native American Research Center for Health;Participant;Preparation;Principal Investigator;Problem-Based Learning;Program Evaluation;programs;Public Health Schools;Qualifying;recruit;Research;Research Personnel;Research Project Grants;Research Training;reservation-based;Risk;Role;Site Visit;skills;success;Surgical Oncologist;Telephone;Training;Training Programs;tribal community;Tribal group;tribal health;Tribes;Trust;trustworthiness;webinar;Work;Writing

PROJECT_TITLE: Cancer Prevention and Control


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BALTIMORE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The process of ribosome-associated quality control (QC) is critical for cellular fitness in bacteria: its loss often results in decreased pathogenicity, viability, or antibiotic resistance. This project aims to characterize the mechanism of a novel ribosome-associated QC factor HrpA, which has been shown to mitigate the effects of ribosome-targeting antibiotics on bacterial growth. Findings from the proposed experiments can be used for future development of HrpA-targeting antimicrobials for treating human disease.

PI_NAMEs: CAMPBELL, ANNABELLE  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Affect;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;ATP Hydrolysis;ATP phosphohydrolase;Bacteria;Binding;Biochemical;Biological Assay;Borrelia burgdorferi;Cells;Cues;density;Dependence;Development;endonuclease;Escherichia coli;Escherichia coli Proteins;experimental study;Family;fitness;Future;genome-wide;Growth;Human;human disease;Hydrolysis;Hypersensitivity;In Vitro;in vivo;insight;Lyme Disease;Mammalian Cell;Messenger RNA;Modification;mouse model;Mutation Analysis;novel;Orthologous Gene;pathogenic bacteria;Pathogenicity;Pathway interactions;Peptides;peptidyl-tRNA;Pharmaceutical Preparations;Polyribosomes;Positioning Attribute;Predisposition;premature;Process;Proteins;Proteobacteria;Quality Control;recruit;Recycling;Reporter;Resources;ribosome profiling;Ribosomes;RNA;RNA Helicase;Role;Saccharomyces cerevisiae;Sedimentation process;Site;Stress;Sucrose;System;Techniques;Testing;tmRNA;transcriptome;transcriptome sequencing;translation factor;Translations;transmission process;Yeasts

PROJECT_TITLE: The role of HrpA in ribosome-associated quality control in E. coli

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse

PROJECT_TERMS: Advertising;Alaska Native;Alaska Native population;American Indian Population;American Indians;Applications Grants;Area;Behavioral;Cancer Control;Cardiovascular Diseases;career;career development;Clinical;Communities;Development;distrust;doctoral student;Educational workshop;experience;Faculty;Fostering;Funding;Goals;graduate student;Grant;Health;health disparity;Health Occupations;Health Professional;Health Sciences;Health Services;Idaho;innovation;Manuscripts;meetings;Modeling;Morbidity - disease rate;mortality;Native American Research Center for Health;Native-Born;Needs Assessment;Oregon;outreach;Polynesian;Population Research;Postdoctoral Fellow;programs;Protocols documentation;recruit;Reduce health disparities;Research;research and development;Research Personnel;Research Project Grants;Research Support;Research Technics;Research Training;Resources;Role;role model;Science;skills;Structure;Students;success;summer institute;summer program;summer research;Training;training opportunity;Training Programs;Tribal group;tribal health;Tribes;undergraduate student;United States Indian Health Service;Universities;Washington;Writing

PROJECT_TITLE: Summer Research Training Institute for AI /AN Health Professionals


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Neurodegenerative;Neurosciences;Peripheral Neuropathy

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Radiculopathy is a common spinal condition resulting from compression and irritation of the spinal nerve roots, leading to sensory deficits, muscle weakness, and pain. Clinicians use dermatomal sensory testing to localize the level(s) of nerve root injury in radiculopathy; however, dermatomal maps are limited and remain to be quantitatively validated. Here we will use spinal cord functional magnetic resonance imaging (fMRI) to test hypotheses central to dermatomal maps, advance our knowledge of spinal cord sensory processing in healthy and injured states, and provide preliminary validation of diagnostic markers for radiculopathy while improving our spinal cord fMRI methods.

PI_NAMEs: WEBER, KENNETH ARNOLD (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Acceleration;Affect;Age;age stratification;Brain;Cervical Radiculopathies;Classification;Clinical;Clinical assessments;clinical examination;clinical practice;Cutaneous;dermatome;diagnostic biomarker;diagnostic value;Digit structure;dorsal horn;Electromyography;Esthesia;Excision;experimental study;Female;Functional Magnetic Resonance Imaging;Goals;Hand;Head and neck structure;healthy volunteer;Human;Image;Image Analysis;improved;in vivo;Individual;Inferior;injured;Injury;Interdisciplinary Study;irritation;Knowledge;Left;Location;machine learning algorithm;Magnetic Resonance Imaging;male;Maps;Methods;Monitor;Motor;Muscle Weakness;Nerve;Nervous System;Nervous System Trauma;neural;Neuroanatomy;Neurologic Effect;Noise;novel;open source;Pain;Patients;physically handicapped;predictive marker;Radiculopathy;Research;Resolution;Sensitivity and Specificity;Sensory;sensory stimulus;Severities;sex;Sex Differences;Side;Signal Transduction;Site;Spatial Distribution;Spinal;Spinal Cord;spinal cord imaging;spinal cord mapping;Spinal Ganglia;Spinal nerve root structure;Spinal nerve structure;Stimulus;Surface;Testing;tool;Uncertainty;Upper Extremity;Validation;Work

PROJECT_TITLE: Dermatomal Mapping with Spinal Cord Functional Magnetic Resonance Imaging

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Data Science;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Substance Misuse

PI_NAMEs: LAPIDUS, JODI A (contact)

PROJECT_TERMS: Address;Behavioral;Benchmarking;Biological;Biometry;Biostatistical Methods;career;career development;Clinical;cohort;Communication;Communities;Companions;Competence;Complex;complex data;computer program;Data;Data Analyses;data handling;Data Science;Data Scientist;Data Sources;data visualization;data wrangling;design;Development;Distance Learning;Educational Curriculum;Educational workshop;Employee;Epidemiology;Ethics;Etiology;Evaluation;Fostering;Funding;Glean;Goals;Grant;Health;health disparity;Health Priorities;Health Professional;health science research;Health Sciences;Home;improved;Individual;insight;Institution;interest;Investigation;Knowledge;Lead;meetings;member;Mentors;Mentorship;Methods;minority scientist;Modernization;Native American Research Center for Health;novel;Participant;Persons;Play;Population;population based;practical application;Process;Productivity;programs;Proliferating;Publishing;Research;Research Personnel;Role;Schedule;Science;Scientist;skills;social;sound;Statistical Computing;Strategic Planning;Stress;Students;Time;Training;Training Programs;tribal community;tribal health;Tribes;Trust;United States National Institutes of Health;Work

PROJECT_TITLE: Improving Applied Biostatistics Skills for AI/AN Researchers


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: PROVIDENCE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative It has become feasible for small research groups to sequence individual genomes and for larger groups to sequence tens of thousands of individuals. This proposal offers a method to discover and validate disease- causing splicing mutations within large scale sequencing data. Furthermore, we believe this work will help us to understand different manifestation of disease symptoms observed in different patients.

PI_NAMEs: FAIRBROTHER, WILLIAM G (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Affect;Alleles;Antisense Oligonucleotides;autism spectrum disorder;base;Basic Science;biobank;Biological Assay;Cell Line;Classification;Clinical;ClinVar;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;combinatorial;Contractor;Data;de novo mutation;Defect;design;Disease;Elements;Engineering;Enhancers;exome;exon skipping;Exons;Frequencies;functional genomics;Funding;Future;Genes;Genetic;Genome;Genomics;Genotype-Tissue Expression Project;Grant;Healthcare Systems;Hereditary Disease;Human;human disease;improved;Individual;Introns;Large-Scale Sequencing;Left;Maps;Measures;Methods;Missense Mutation;Modeling;mRNA Precursor;mutant;Mutate;Mutation;Nonsense Mutation;Organ;Patients;Phenotype;Physician Executives;Pilot Projects;Population;Predisposition;Privatization;Property;protein function;Reporter;repository;Research;Research Personnel;RNA Splicing;Role;SARS-CoV-2 B.1.1.7;Signal Transduction;Site;Spliced Genes;Symptoms;Technology;Testing;Tissues;Universities;Untranslated RNA;Variant;Work

PROJECT_TITLE: Discovering Splicing Defects in Human Genes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-V(02)M]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Heart Disease;Precision Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative Atrial fibrillation (AF), the most common abnormal heart rhythm worldwide, is associated with increased risk for stroke, heart failure and death. Treatments for AF are sub-optimal because of poor understanding of the underlying mechanisms; here we propose to determine if the variable response to antiarrhythmic drugs for AF is due to genetics. Our studies will not only improve the prediction of response to drugs but will also improve our understanding of the underlying mechanisms and help in the development of new treatments.

PI_NAMEs: DARBAR, DAWOOD  (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: 4q25;Acids;Adherent Culture;Adopted;Adverse effects;Adverse event;Affect;Alleles;American;Anti-Arrhythmia Agents;Arrhythmia;Atrial Fibrillation;Atrial Function;Cardiac;Cardiac Myocytes;Catheters;Cell Culture Techniques;Cell Line;Cells;Cessation of life;channel blockers;Chromosomes;Clinical;Cross-Over Studies;Data;Development;Electrophysiology (science);Engineering;Epidemic;Ethnic Origin;Ethnic Population;experience;Extracellular Matrix;Feasibility Studies;Flecainide;Genetic;genetic approach;Genetic Carriers;genetic variant;Genotype;Heart Abnormalities;Heart Atrium;Heart failure;heart rhythm;Heterogeneity;Human;human embryonic stem cell;human induced pluripotent stem cells;Implant;implantation;improved;in vivo;individual patient;individual response;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Knowledge;Level of Evidence;Measures;Membrane;Modeling;Monitor;Morbidity - disease rate;mortality;mouse model;novel;outcome prediction;Patient Care;Patients;personalized medicine;Pharmaceutical Preparations;Pharmacogenomics;Phenotype;Pilot Projects;Potassium Channel;Pre-Clinical Model;Preclinical Testing;predicting response;Prediction of Response to Therapy;Predisposition;prospective;Proteins;Protocols documentation;Publishing;Race;racial population;Randomized;Recurrence;Reporting;response;Risk;risk minimization;risk variant;Single Nucleotide Polymorphism;Sotalol;stroke risk;success;Surrogate Markers;Symptoms;Testing;therapeutic target;Toxic effect;Translations;Treatment Efficacy;treatment response;Tretinoin

PROJECT_TITLE: Genotype-guided therapy for atrial fibrillation

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Kidney Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE A promising approach to halt, and even reverse, the progression of acute kidney injury is to administer mesenchymal stem cell (MSC) based therapies [i.e. parent MSCs (a cellular therapy) or MSC-derived extracellular vesicles (a cell free therapy)] directly into the kidney, via its arterial blood supply. In the present study, we will examine how these therapies can regenerate the kidney when locally administered, specifically focusing on how they modulate the heat shock protein pathway. In addition, we will examine how using pulsed sound waves can facilitate kidney regeneration, either by causing changes in the local microenvironment or by stimulating intrinsic regenerative pathways.

PI_NAMEs: THAKOR, AVNESH SINH (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Affect;Animals;Anti-Inflammatory Agents;Apoptosis;Apoptotic;Biodistribution;bone marrow mesenchymal stem cell;Cell Adhesion Molecules;cell injury;Cell Proliferation;Cell Therapy;Cells;Chronic Kidney Failure;Cisplatin;Clinical;clinical translation;Custom;cytokine;Development;Eligibility Determination;experimental study;extracellular vesicles;FDA approved;Fibrosis;Filtration;Focused Ultrasound;Heat shock proteins;heat-shock proteins 20;Heat-Shock Proteins 70;hemodynamics;Homing;Hospitalization;Human;image guided;Immune;immunoregulation;improved;In Vitro;Inflammasome;Inflammation;Injury;Injury to Kidney;innovation;Intervention;Intra-Arterial Infusions;Intra-Arterial Injections;Intravenous;intravenous administration;Kidney;Kidney Failure;Left;Lung;Mechanical Stimulation;Mesenchymal Stem Cells;minimally invasive;Molecular;mouse model;Mus;Natural regeneration;Nature;new technology;Organ;paracrine;Parents;Pathway interactions;Patients;Pharmaceutical Preparations;Physiologic pulse;Pre-Clinical Model;protective effect;Proteomics;Proto-Oncogene Proteins c-akt;radiologist;regenerative;Regenerative capacity;Regenerative pathway;release factor;renal damage;Renal function;repaired;Reproducibility;response;Reticuloendothelial System;Route;sound;Source;stem cell therapy;Surface;Techniques;Technology;Testing;tissue regeneration;Tissues;transcriptome sequencing;Transducers;Vascular blood supply;Work

PROJECT_TITLE: Treating Kidney Injury by Modulating Heat Shock Proteins Using Soundwaves Combined with Mesenchymal Stem Cells and Their Extracellular Vesicles

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Extreme heat may threaten the effectiveness of interventions for child physical activity including the national program Safe Routes to School. Using modeled estimates of heat stress and children's geolocated physical activity on school routes, the proposed research will determine the relations between built environment changes from Safe Routes to School, children's exposure to ambient temperature, and their active school commuting behavior. Research findings can provide evidence for whether urban heat management strategies are needed to be incorporated as environmental interventions within Safe Routes to School and other programs designed to promote physical activity.

PI_NAMEs: LANZA, KEVIN LAI (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Accelerometer;Adult;Age;Air;Air Pollutants;Air Pollution;Area;Behavior;Bicycling;Blood flow;Body Temperature;built environment;cardiovascular disorder risk;career development;Child;Child Health;Climate;climate change;cohort;Color;Communities;community based participatory research;Commuting;cost;Data;design;Development Plans;Diabetes Mellitus;Disparity;Effectiveness of Interventions;Enrollment;Environment;Environmental Exposure;environmental intervention;environmental justice;Equity;Evaluation;experience;Exposure to;extreme heat;Familiarity;Feasibility Studies;fifth grade;Health;Health behavior;health equity;Heat Stress;Heat Stress Disorders;Home;improved;Incentives;Infrastructure;Injury;innovation;Intervention;Investments;Learning;Literature;Low income;Malignant Neoplasms;Maps;Measures;Methods;Modeling;Municipalities;Neighborhoods;Output;Parents;Participant;Personal Satisfaction;Physical activity;Plants;Policies;post intervention;programs;Public Health Schools;Recommendation;recruit;Research;Research Personnel;Risk;Risk Reduction;Route;Safety;safety education;Sampling;School Enrollments;school environment;School-Age Population;Schools;sensor;Skin;spatiotemporal;Statistical Data Interpretation;Students;Surveys;Techniques;Temperature;Testing;Texas;third grade;Training;Transportation;Travel;Trees;Urbanization;Walking

PROJECT_TITLE: Routes to Environmental Justice: Assessment of Ambient Environmental Exposures for Safe Routes to School Programs


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Effective mentorship of junior clinical investigators is critically important in order to train the next generation of biomedical scientists. Through this K24 grant, trainees will learn innovative, cutting-edge translational techniques in patient-oriented research to study platelet-leukocyte interactions in sepsis.

PI_NAMEs: RONDINA, MATTHEW THOMAS (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: adverse outcome;Agonist;Antigen Presentation;Antigen Presentation Pathway;Antigen-Presenting Cells;Antigens;Apoptosis;Area;Award;Bioinformatics;Biological;biomedical scientist;Blood Platelets;Cardiovascular Diseases;career;career development;CD8-Positive T-Lymphocytes;Cell Count;Cell Physiology;Cells;Cellular biology;Cessation of life;Clinical;Clinical Data;Clinical Investigator;Clinical Research;cohort;Communicable Diseases;Critical Care;cytokine;Data;Data Collection;design;Discipline;Doctor of Philosophy;Effectiveness;Effector Cell;Event;Fellowship;Funding;Gene Expression;gene function;genome editing;Grant;Hematology;Human;Immune System Diseases;Immunity;Immunology;Immunosuppression;Impairment;improved;Inflammatory;innovation;innovative technologies;Knowledge;Learning;Leukocytes;Lung;Major Histocompatibility Complex;Malignant Neoplasms;Mediating;Megakaryocytes;Mentors;Mentorship;Methods;Mid-Career Clinical Scientist Award (K24);Midcareer Investigator Award in Patient-Oriented Research;Molecular;Molecular Medicine;monocyte;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;next generation;novel;novel therapeutic intervention;Outcome;Participant;Pathogenicity;patient oriented research;Patients;Peptides;Phenotype;platelet function;Process;programs;Proteins;Proteome;Publishing;recruit;Research;Research Activity;Research Personnel;Research Project Grants;response;Risk;RNA;Role;role model;Sample Size;Sampling;secondary infection;Secondary to;Sentinel;Sepsis;septic;septic patients;skills;Students;Supervision;Survivors;Syndrome;T-Lymphocyte;Techniques;Testing;Time;Tissue-Specific Gene Expression;TNFSF15 gene;tool;Training;transcriptome;transcriptome sequencing;Underrepresented Minority;Universities;Up-Regulation;Utah;Work

PROJECT_TITLE: Platelet-Leukocyte Interactions in Sepsis


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative Inherited retinal degenerations and age-related macular degeneration affect more than two million people in the United States. For 90% of the people afflicted with these diseases, no treatments have been developed. This project will test a drug with strong therapeutic potential, and it will define a specific pathway involving AMPK and PGC-1 that can be activated to protect retinal neurons and RPE from inherited mutations and age-related degeneration. This in vivo study is designed to directly determine the role of mitochondrial gene expression and function as a contributing factor to inherited retinal degeneration and age-dependent macular degeneration.

PI_NAMEs: ASH, JOHN D (contact);DU, JIANHAI

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 5'-AMP-activated protein kinase;Adenosine Monophosphate;Affect;Age;age related;Age related macular degeneration;Aging;Biogenesis;Biological Assay;Catalytic Domain;Cell Nucleus;Cells;cofactor;Data;Data Analyses;Defect;design;Development;Disease;Functional disorder;gain of function;Gene Expression;gene function;Genes;Genetic Transcription;Glucose;Glutamate Metabolism Pathway;Glutamine;Goals;in vivo;Inherited;inherited retinal degeneration;Knockout Mice;Label;Light;Link;loss of function;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Metformin;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial metabolism;Mus;Mutation;Nuclear;oxidative damage;Pathway interactions;Persons;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Photoreceptors;Ploidies;PPAR gamma;Publishing;receptor;repaired;Research;response;Retina;Retinal Degeneration;retinal neuron;Retinal Photoreceptors;Rod;Role;single-cell RNA sequencing;Sorting;Testing;Therapeutic;Thinness;Tissues;transcriptome sequencing;United States;uptake

PROJECT_TITLE: Regulators of retinal metabolism in healthy and degenerating retinas

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


NIH_SPENDING_CATS: Genetics

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative We classically understand changes in the biology of cells and tissues as determined by how cells relay information from outside to their nucleus, in order to turn genes off and on. While this framework has helped explain the majority of biological research to date, it largely overlooks the fact that cell biology also requires the movement of a vast number of metabolites throughout the compartments inside a cell and between cells in a tissue. This proposal seeks to investigate how the movement of metabolic information within a cell and amongst populations of interacting cells controls how genes are turned off and on and how cells behave collectively inside an animal.

PI_NAMEs: BAILIS, WILL H. (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Animals;Bar Codes;Binding;Biochemical;Biochemistry;Biological Models;biological research;Biology;Body System;Cell Communication;Cell Differentiation process;Cell membrane;Cell Nucleus;Cells;Cellular biology;cellular development;Cellular Structures;chromatin remodeling;combinatorial;CRISPR screen;Cytosol;Development;Enzymes;Epigenetic Process;Eukaryota;Gene Expression Regulation;Genes;genetic approach;Genetic Transcription;Hematopoietic;Hematopoietic System;Histones;In Vitro;in vivo;insight;Maps;Membrane;Membrane Transport Proteins;Metabolic;Metabolism;Mitochondria;Molecular;Molecular Biology;Movement;novel;Nuclear Envelope;Organelles;Population;Process;programs;Prokaryotic Cells;response;reverse genetics;System;Testing;Tissues;transcriptional reprogramming;transmission process

PROJECT_TITLE: Examining how the spatial partitioning of metabolism underlies cell state

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

PHR: PROJECT NARRATIVE Despite intensive therapy, patients with high-risk neuroblastoma frequently suffer from relapses that prove fatal. To prevent and treat relapse, we need a better understanding of how to target the populations of cancer cells that survive our current therapies. This proposal aims to target drug-resistant cancer cells by exploiting differences in how they sense inflammatory stimuli in order to enhance their susceptibility to immunotherapy.

PI_NAMEs: WOLPAW, ADAM J (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Adrenergic Agents;Award;Bilateral;cancer cell;career;CD8-Positive T-Lymphocytes;Cell Line;Cell Survival;Cells;Chemoresistance;Childhood Solid Neoplasm;Chromatin;chromatin immunoprecipitation;Clinical;clinical training;clinically actionable;clinically relevant;Complex;Contralateral;CRISPR/Cas technology;Data;Development;Diagnosis;DNA;DNA Methylation;DNA Methylation Inhibition;Drug Targeting;education planning;Epigenetic Process;epigenomic profiling;epigenomics;experience;EZH2 gene;Fostering;Foundations;Future;Genes;Goals;Growth;high risk;Human;Immune;immune cell infiltrate;immune checkpoint blockade;Immune response;Immune Targeting;Immunity;Immunocompetent;Immunodeficient Mouse;immunogenic;Immunotherapeutic agent;Immunotherapy;Implant;improved;improved outcome;In Vitro;in vivo;Inflammatory;Inflammatory Response;inhibitor;Knock-out;Learning;Malignant Neoplasms;Measures;Mediating;Mentors;Mesenchymal;Methylation;Minor;Modeling;mortality;mouse model;Mus;Neuroblastoma;neuroblastoma cell;novel;Outcome;overexpression;Pathway interactions;Patients;Pediatric Hospitals;Pediatric Oncologist;Pennsylvania;Philadelphia;Physicians;Population;Positioning Attribute;Predisposition;prevent;promoter;Radiation;Radiation Induced DNA Damage;radiation response;Radiation therapy;refractory cancer;Regulation;Relapse;Reporting;Repression;Research;Resources;response;restoration;Scientist;sensor;Signal Transduction;skills;Stimulator of Interferon Genes;Stimulus;subcutaneous;synergism;Target Populations;Testing;The Wistar Institute;therapeutic target;Training;Training Programs;transcription factor;Transcriptional Regulation;translational study;Treatment Efficacy;Treatment Failure;tumor;Tumor Promotion;tumor-immune system interactions;Universities;Vocational Guidance;Work

PROJECT_TITLE: cGAS-STING and therapeutic immune responses in neuroblastoma

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: MUSKEGO

ORG_NAME: XLOCK BIOSCIENCES, LLC

ORG_STATE: WI

PHR: PROJECT NARRATIVE Chemokines are soluble proteins that direct migrating immune cells to sites of injury or infection. Aberrant chemokine function contributes to cancer, chronic inflammation and autoimmune disease. CCL20 levels are elevated the joints of psoriatic arthritis patients. XLock Biosciences is developing a lead molecule (CCL20LD) that blocks this chemokine and reduced joint and tendon inflammation in a preclinical study. This Phase II SBIR project will perform the R/R&D necessary for an IND application leading to first-in-human trials of CCL20LD as a psoriatic arthritis therapy.

PI_NAMEs: CLARKE, WILLIAM R (contact);VOLKMAN, BRIAN F

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: Affect;Alkaline Phosphatase;Alternative Therapies;Animal Model;Animals;Antibodies;arthritis therapy;arthropathies;Autoimmune Diseases;autoinflammatory diseases;Biochemical;Biological;Biological Response Modifier Therapy;Biological Sciences;Bone Injury;Candidiasis;CCL20 gene;CCR6 gene;Cells;chemokine;Chronic Disease;Clinical;Clinical Trials;clinically relevant;Connective Tissue;Creatinine;Data;Dermatitis;Development;Diagnosis;dimer;Disease;disease model;DNA;Dose;drug development;effective therapy;Engineering;Etanercept;experimental study;FDA approved;first-in-human;Formulation;Funding;G-Protein-Coupled Receptors;Generations;Goals;Half-Life;Hepatotoxicity;high risk;Homeostasis;Human;human disease;human model;Humira;IL17 gene;Immune;immune function;Immune response;immunoregulation;Immunosuppression;improved;in vivo;Infection;infection risk;Inflammation;Inflammatory;infliximab;inhibitor;Injections;Injury;innovation;interleukin-23;joint inflammation;Joints;Lead;Ligands;Liver;Malignant Neoplasms;manufacture;Measures;Mediating;medical schools;Metabolic Clearance Rate;Methods;migration;milligram;Modeling;Modification;Molecular;mouse model;Mucous Membrane;Mus;Mycoses;nephrotoxicity;novel therapeutics;Pathology;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;pre-clinical;preclinical development;preclinical study;Preclinical Testing;Predisposition;preservation;prevent;Production;Proteins;Protocols documentation;Psoriasis;Psoriatic Arthritis;Publishing;Quality Control;Quality of life;radiological imaging;receptor;Recombinant Proteins;recruit;Reproducibility;research and development;Risk;Rodent;Safety;Schedule;side effect;Signal Transduction;Signs and Symptoms;Site;Skin;Skin Tissue;Small Business Innovation Research Grant;success;Symptoms;Tendon structure;Testing;Therapeutic;Therapeutic Effect;therapeutic lead compound;Time;Tissues;Treatment Efficacy;Treatment Protocols;Tuberculosis;tumor necrosis factor-alpha inhibitor;Urea;Variant;Wisconsin

PROJECT_TITLE: Targeting the CCR6-CCL20 pathway for treatment of psoriatic joint and entheseal inflammation


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Rural Health

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PI_NAMEs: VAN SCOY, LAUREN JODI (contact)

PROGRAM_OFFICER_NAME: LEYVA, FRANCISCO

PROJECT_TERMS: Acceleration;Biomedical Research;career development;catalyst;Clinical Sciences;Collection;community engaged research;Data;design;Development;Enrollment;Ethnic Origin;expectation;flexibility;Fostering;Funding;Goals;Grant;Health;improved;Individual;innovation;Institution;Learning;Learning Module;Logic;Mentors;Mentorship;Modeling;next generation;Outcome;Pathway interactions;Process;Productivity;Program Development;programs;Race;recruit;Request for Applications;Research;Research Infrastructure;Research Methodology;Research Personnel;resilience;rural environment;Rural Health;skills;Talents;Technology;Time;Training;Translational Research;translational scientist;Universities

PROJECT_TITLE: I: Penn State Institutional Career Development Core


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Human and animal organ size and shape are precisely controlled by a patterning process during embryonic development and individual growth. Our current knowledge about this patterning process is still limited. The outcome of this project will demonstrate a previously less recognized patterning mechanism by ion channel- mediated bioelectricity, and this knowledge could be used for developing preventive and therapeutic interventions of human congenital diseases in the future.

PI_NAMEs: ZHANG, GUANGJUN  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TITLE: Roles of ion-channel mediated bioelectricity in developmental patterning

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Clinical Research;HIV/AIDS;Immunization;Infectious Diseases;Pediatric;Pediatric - AIDS

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative New treatment strategies to end the HIV epidemic are urgently needed and currently being studied, including the administration of broadly neutralizing antibodies against HIV. Mutations in the virus, however, can cause resistance to these antibodies. We propose to study mutations in HIV in depth that cause resistance against antibodies in a large number of samples from resource-limited areas, for a better understanding of the role these mutations play for antibody therapy in these settings.

PI_NAMEs: JILG, NIKOLAUS  (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: Advisory Committees;Affect;Africa South of the Sahara;AIDS clinical trial group;Antibodies;Antibody Therapy;antiretroviral therapy;Basic Science;Binding;Botswana;career development;Child;Chronic;Clinical;Clinical Data;Clinical Trials;Collection;Combined Modality Therapy;Communicable Diseases;Data;deep sequencing;design;Development Plans;Dideoxy Chain Termination DNA Sequencing;Disease remission;Drug resistance;early phase clinical trial;Education;Epidemic;Epitopes;Europe;experience;Failure;Fellowship;General Hospitals;Genotype;Goals;Hepatitis C;HIV;HIV Infections;HIV resistance;HIV Seropositivity;HIV-1;Hospitals;Individual;Infection;Interruption;Intervention;Knowledge;Maintenance;Massachusetts;member;Mentors;Mentorship;Minority;Mutation;Mutation Analysis;Names;Natural Immunity;neutralizing antibody;next generation;North America;novel;novel therapeutic intervention;pathogen;Patients;Pattern;perinatal HIV;Persons;Phenotype;Physicians;Plasma;Play;Polysaccharides;Predisposition;Prevalence;Prevention;Process;programs;Publishing;Research;Research Personnel;Resistance;resistance mutation;Resource-limited setting;RNA;Role;Sampling;Scientist;Site;skills;Testing;Time;tool;Training;Translational Research;Treatment Failure;Variant;Viral;viral rebound;virology;Virus;Virus Diseases;Woman;Work

PROJECT_TITLE: Relevance of Resistance Mutations for the Susceptibility to Broadly Neutralizing Antibodies Against HIV-1

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_DEPT: PEDIATRICS

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative: Long distance signaling and trafficking of proteins in neuronal axons is important for neurodevelopment and for responses to nerve injury, while impaired axonal trafficking is a hallmark of many neurodegenerative disorders. This work focuses on how a protein-lipid modification called palmitoylation controls the long distance transport and activity of axonal signaling enzymes that control the balance between axonal maintenance and degeneration. The proposed research will provide new insights into axonal biology and has the potential to enhance understanding of neurodegenerative conditions in which axonal trafficking and signaling is impaired.

PI_NAMEs: THOMAS, GARETH  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Acute;Acyltransferase;Address;Axon;axon injury;Biological Assay;Biology;conditional knockout;deprivation;Distal;Elements;Enzymes;Equilibrium;experimental study;Family;Funding;Genetic;Genetic Transcription;Goals;Impairment;in vivo;injured;Injury;insight;knock-down;Knockout Mice;Leucine Zippers;Lipids;Maintenance;MAPK10 gene;MAPK8 gene;MAPK9 gene;Mediating;Mitogen-Activated Protein Kinases;Modeling;Modification;Molecular;Monomeric GTP-Binding Proteins;mutant;N-terminal;Nerve Degeneration;nerve injury;neural;Neurodegenerative Disorders;neurodevelopment;neuronal cell body;Neurons;neuropathology;neurotransmission;novel;novel therapeutics;overexpression;Palmitates;palmitoylation;Pathway interactions;pharmacologic;Phosphorylation;Phosphotransferases;Play;Process;programs;Property;protein transport;Proteins;Regulation;Research;response;Retinal Ganglion Cells;Role;Signal Pathway;Signal Transduction;small hairpin RNA;Spinal Ganglia;Stimulus;Testing;trafficking;ubiquitin ligase;Variant;Vesicle;Viral;Wallerian Degeneration;Work

PROJECT_TITLE: Regulation of Axonal Signaling by Palmitoylation

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Human Genome;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Narrative: We will establish a robust methodology for exosome isolation and characterization followed by a comprehensive and genome-wide evaluation of exosomal and circulating microRNAs in plasma samples as potential noninvasive biomarkers for the early detection and prevention of hepatocellular cancer. Successful identification of microRNA biomarkers will exert a substantial diagnostic and prognostic impact on the management of this fatal disease.

PI_NAMEs: GOEL, AJAY  (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Alcohol abuse;Bioinformatics;Biological Assay;Biological Markers;biomarker discovery;biomarker panel;Blood;Blood Specimen Collection;Cancer Etiology;Cell Line;Cells;Cessation of life;Chronic Hepatitis;circulating microRNA;Circulation;Clinical;clinically relevant;cohort;Collection;cost;Data;Death Rate;Detection;Diagnostic;diagnostic value;differential expression;Disease;early detection biomarkers;Early Diagnosis;Early identification;Early treatment;Etiology;Evaluation;Excretory function;exosome;extracellular vesicles;fatty liver disease;genome-wide;Hepatic;high risk;Human;imaging modality;Impairment;Incidence;Individual;liquid biopsy;Liver;Liver Cirrhosis;liver function;Machine Learning;Malignant neoplasm of liver;Malignant Neoplasms;Messenger RNA;Methodology;microRNA biomarkers;MicroRNAs;Modality;Molecular;Molecular Profiling;Mutation;Neoplasms;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;Obesity;patient population;Patients;Perception;Performance;Plasma;Population;Prevention;Primary carcinoma of the liver cells;prognostic;prospective;Prospective cohort;Protocols documentation;Reproducibility;Research;resilience;Sampling;screening;Sensitivity and Specificity;Small RNA;Specificity;Specimen;Standardization;Surveillance Methods;Systemic Therapy;Tissues;transcriptome sequencing;Translational Research;Tumor Markers;ultrasound;Viral;Virus;α-Fetoproteins

PROJECT_TITLE: Exosomal biomarkers for the early detection of hepatocellular carcinoma

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ORG_CITY: GAINESVILLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE  On the surfaces of human cells, sensory proteins are activated by not only by molecules outside the cell but also by lipids of the membrane environment in which they function. We seek to understand how the cellular membrane environment affects the activities of these sensory proteins, including affecting their abilities to bind drugs and transmit information inside the cell that ultimately causes physiological responses. The results of this work provide fundamental information into how receptor- lipid interactions in the membrane can be leveraged to design novel inhibitory or activating drug molecules.

PI_NAMEs: EDDY, MATTHEW THOMAS (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Address;ADORA2A gene;Affect;Allosteric Regulation;Alzheimer's Disease;Binding;Biological Assay;biophysical tools;Cells;Cellular Membrane;Characteristics;chemical property;Chemicals;Cilia;Complex;Data;design;Disease;Drug Design;Drug Modulation;Drug Targeting;Environment;Family;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Goals;Heart Diseases;Human;Investigation;Knowledge;Learning;Lipids;Malignant Neoplasms;Mediating;Membrane;Membrane Lipids;Membrane Proteins;Modeling;novel;Organelles;Pharmaceutical Preparations;Pharmacology;physical property;Physiological;Physiological Processes;Physiology;programs;Property;Protein Dynamics;Proteins;receptor;receptor function;Receptor Signaling;Research;response;Rhodopsin;Role;Sensory;Signal Transduction;Signaling Protein;smoothened signaling pathway;solid state nuclear magnetic resonance;Structure;Surface;Time;transmission process;Work

PROJECT_TITLE: Allosteric Regulation of Human G Protein-Coupled Receptors by Membrane Lipids

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse

ORG_CITY: BOSTON

PHR: 8. PROJECT NARRATIVE An alarming rise in the injection of opioids is fueling the HIV epidemic in India, with young people who inject drugs (YPWID)—i.e., individuals 18-29 years of age—bearing a disproportionate burden of new HIV infections. We propose to develop Yuva Sath, a novel peer-led behavioral intervention for YPWID—tailored to their unique developmental vulnerabilities—that will support their engagement in substance use treatment and HIV prevention services by addressing the diverse barriers they experience. This research will lead to one of the first youth tailored interventions for HIV prevention among YPWID in India and contribute to urgent efforts to address the high HIV incidence in this vulnerable population.

PI_NAMEs: GANAPATHI, LAKSHMI  (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Age Years;AIDS prevention;antiretroviral therapy;Automobile Driving;Award;Behavior Therapy;Behavioral Medicine;career development;Caring;Cellular Phone;Childhood;Cities;Clinical;Collection;Communicable Diseases;condoms;Counseling;Data;Development;disorder prevention;Drops;Effectiveness;effectiveness trial;Epidemic;Evaluation;Evidence based intervention;experience;Fellowship;flexibility;Focus Groups;Future;Goals;Government;Heroin;high risk;high risk behavior;HIV;HIV Infections;HIV risk;HIV Seropositivity;Human immunodeficiency virus test;Hybrids;implementation intervention;implementation science;improved;Incidence;India;Individual;Injecting drug user;Injections;innovation;integrated care;Intervention;Intervention Studies;Lead;Life;medical schools;medication for opioid use disorder;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Modeling;Modification;multidisciplinary;National Institute of Drug Abuse;Needle-Exchange Programs;Needles;Nongovernmental Organizations;novel;opioid injection;opioid use disorder;Outcome;outreach;Participant;patient oriented research;Patients;peer;Peer Pressure;peer support;person centered;Persons;Physicians;Policies;pre-exposure prophylaxis;preference;prescription opioid;Prevalence;prevention service;preventive intervention;primary outcome;Problem Solving;Provider;psychosocial;Public Health;public health priorities;Randomized;Randomized, Controlled Trials;reduced substance use;Research;Research Infrastructure;Research Personnel;Retrospective cohort;Risk Behaviors;risk perception;scale up;secondary analysis;secondary outcome;Services;Signal Transduction;skills;sociodemographics;Specific qualifier value;Statistical Methods;Statistical Study;Subgroup;substance use;substance use treatment;Testing;testing uptake;therapy adherence;therapy design;therapy development;Time;Training;Transportation;treatment as usual;United States National Institutes of Health;uptake;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Yuva Sath: A peer-led intervention to support substance use treatment and HIV prevention among young people who inject drugs in India

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biodefense and Related Countermeasures;Cardiovascular;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project narrative: Latent tuberculosis infection affects 1.7 billion people globally, and is a common coinfection in persons living with HIV. In this project, we will define the role of latent tuberculosis infection as a contributor of atherosclerotic cardiovascular disease risk and immune activation in persons living with HIV. We will therefore examine a prevalent, preventable, and treatable coinfection in persons with HIV to inform the design of future interventions to decrease the risk of cardiovascular disease in this population.

PI_NAMEs: HUAMAN JOO, MOISES ARTURO (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Acute myocardial infarction;Address;Affect;Aftercare;age group;aged;Angiography;Antimycobacterial Agents;antiretroviral therapy;Aorta;Area;Arterial Fatty Streak;Atherosclerosis;atherosclerosis risk;Biological Markers;Calcium;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;CD36 gene;Cells;Clinic;clinically relevant;co-infection;cohort;Coronary;Coronary Arteriosclerosis;Coronary artery;coronary computed tomography angiography;coronary plaque;cytokine;Data;density;design;Development;Diameter;Enrollment;Epidemic;Event;Exhibits;experimental study;Flow Cytometry;Future;General Population;Genus Mycobacterium;high dimensionality;High Prevalence;high risk;high risk population;HIV;HIV Infections;HIV/TB;Immune;immune activation;immune modulating agents;In Vitro;Individual;Infection Control;infection rate;Inflammatory;Interferon Type II;Interleukin-6;Intervention;Intervention Trial;Knowledge;Link;metabolic profile;Modeling;monocyte;mouse model;multiplex assay;Mus;Mycobacterium Infections;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;novel marker;oxidized low density lipoprotein;Participant;Pathogenesis;Peripheral Blood Mononuclear Cell;Persons;Peru;Phenotype;Plasma;Population;Prevalence;prevent;Production;Recording of previous events;recruit;Research;Risk;Risk Factors;Role;scavenger receptor;screening;sex;Stenosis;Stimulus;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Time;TNF gene;Tobacco use;tomography;Tuberculosis;uptake;Variant;Visit

PROJECT_TITLE: Coronary Atherosclerosis and Immune Activation in HIV and Tuberculosis Infection

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Nutrition;Orphan Drug;Pancreatic Cancer;Rare Diseases

PHR: NARRATIVE Aggressive tumors acquire the ability to scavenge and eat nutrients from their environment, which allows them to face starvation and survive even the harshest chemotherapy treatments. To fight those cancers, many scientists are currently working out ways of blocking the ability of cancer cells to scavenge food; however, what if, instead of preventing cancer cells from eating, we simply locked the fridge? Our laboratory at MIT has recently discovered a molecular machine that acts as a gate for the release of food from the fridge, and our goal is to develop drugs that can stop this machine from working, which will effectively starve aggressive tumors, whilst sparing all other normal cells that do not rely on food scavenging.

PI_NAMEs: ROGALA, KACPER  (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Affect;Amino Acids;analog;Area;Arginine;aspirate;Autophagocytosis;Binding;Biochemical;Biological Assay;Biology;cancer cell;cancer type;career;Cell Physiology;Chemicals;chemotherapy;Coupled;Cryoelectron Microscopy;Cytosol;Cytotoxic Chemotherapy;Development;diagnostic tool;DNA;drug development;drug discovery;Eating;effective therapy;Environment;Essential Amino Acids;expectation;experimental study;extracellular;Extracellular Protein;Face;fighting;Food;Future;Gatekeeping;Goals;Growth;Homologous Gene;Human;Impairment;improved;In Vitro;innovation;insight;Integral Membrane Protein;Laboratories;Laboratory Finding;Lead;Learning;Leucine;Libraries;Lipids;lysosomal proteins;Lysosomes;Malignant neoplasm of pancreas;Malignant Neoplasms;Mammalian Cell;Mediating;Medicine;Membrane Proteins;Membrane Transport Proteins;Mentors;Metabolic;metabolomics;Molecular;Molecular Conformation;Molecular Machines;Motivation;mTOR protein;mutant;Mutation;nanobodies;nanodisk;Normal Cell;novel;novel therapeutics;Nutrient;Oncogenic;Outcome;pancreatic cancer cells;Pathway interactions;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Phosphotransferases;Positioning Attribute;prevent;Process;programs;Proliferating;Proteins;proteoliposomes;Protocols documentation;rational design;reconstitution;Recording of previous events;Recycling;Research;Research Personnel;Role;Scientist;screening;Signal Transduction;small molecule;small molecule inhibitor;small molecule libraries;Starvation;structural biology;Structure;success;Testing;therapeutic target;Training;Transport Process;tumor;tumor metabolism;tumor microenvironment;Validation;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Mechanistic insights into lysosomal nutrient efflux in cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE  This program will advance understanding of molecular mechanisms of vascular disease and promote development of new diagnostic, therapeutic, and preventive strategies by studying the regulation of cell adhesion by cells of the blood and vessel wall.

PI_NAMEs: GINSBERG, MARK HOWARD (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: adhesion receptor;Adhesives;Adult;Blood;Blood Platelets;Blood Vessels;CCM1 gene;Cell Adhesion;Cell Physiology;Cell-Cell Adhesion;Cells;Collaborations;Complex;design;Development;Endothelial Cells;Endothelium;Event;experience;feasibility testing;Gene Modified;Gene Silencing;Genes;Genetic;Glass;Heart;Hemostatic function;Human;imaging modality;improved outcome;in vivo;in vivo Model;Individual;Inflammation;Leukocyte Adhesion Deficiency;Leukocytes;Methods;Microfluidics;Molecular;Molecular Conformation;mouse model;Mus;Mutate;neutrophil;novel;novel diagnostics;novel therapeutic intervention;optogenetics;pharmacologic;platelet function;Play;Prevention strategy;Process;programs;protein protein interaction;Regulation;Research Personnel;Resistance;response;Role;Signal Transduction;Structural Biologist;Structure;superresolution imaging;Surface;Talin;Testing;Therapeutic;Thrombosis;Translations;Ubiquitination;Vascular Diseases

PROJECT_TITLE: Cellular Mechanisms of Inflammation, Hemostasis, and Thrombosis

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(JA)]


NIH_SPENDING_CATS: Cardiovascular

PROJECT_TITLE: Core B - Ginsberg-ADMINISTRATIVE CORE

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


NIH_SPENDING_CATS: Cardiovascular;Hematology

PI_NAMEs: BERGMEIER, WOLFGANG  (contact)

PROJECT_TERMS: Adoptive Transfer;Affect;Animal Model;Antibodies;Area;arteriole;Biochemistry;Biological Assay;Biophysics;Bleeding time procedure;Blood Platelets;Carotid Arteries;cost;Data;Data Analyses;Development;Doctor of Philosophy;Equipment;Feedback;ferric chloride;Genotype;Hemostatic function;IACUC;Imaging Techniques;In Vitro;in vivo;Individual;Inferior vena cava structure;Inflammation;Injury;intravital microscopy;laboratory experiment;Laser injury;Lung;Maintenance;Megakaryocytes;Mesentery;Methodology;mid-career faculty;Modeling;Monomeric GTP-Binding Proteins;mouse model;Mouse Strains;Mus;Names;neutrophil;North Carolina;Procedures;Production;programs;Protocols documentation;Quarantine;Reaction;Reproducibility;Research;Research Personnel;Resources;Saphenous Vein;Seminal;Services;Skin;Stenosis;Study models;Tail;Technical Expertise;Thrombosis;Universities;Venous

PROJECT_TITLE: The Hemostasis, Thrombosis, and Inflammation Models Core


PROJECT_TERMS: Achievement;Adhesions;Age;Agonist;Alleles;Binding;Binding Sites;Biological Assay;Blood;Blood Cells;Blood Platelets;Blood Vessels;brain endothelial cell;Carotid Arteries;Cell Adhesion;Cell Physiology;cell type;Cells;Collaborations;Compensation;Data;Development;disabled;Embryo;Endothelial Cells;Endothelium;ferric chloride;Foundations;Hemorrhage;Hemostatic function;Homing;In Vitro;in vivo;Individual;Inflammation;Integrins;Intercellular Junctions;Knockout Mice;Laser injury;Leukocytes;Ligands;Lung;Lymphoid Tissue;Mediating;Megakaryocytes;Modeling;Molecular Conformation;Mus;mutant;Mutation;Nature;neutrophil;overexpression;Pathway interactions;Peripheral;Phenotype;platelet function;Play;recruit;Role;Signal Transduction;Site;Stenosis;Structure;T-Lymphocyte;Talin;Tamoxifen;Testing;Thrombosis;Tumor Angiogenesis;Vena caval structure;Venous Thrombosis

PROJECT_TITLE: Direct Rap1-talin interaction in platelets, leukocytes, and endothelial cells


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Human Genome;Precision Medicine

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: NARRATIVE With the new availability of several treatment options for AML patients harboring IDH1 or IDH2 mutations, it is not known yet how to predict which therapy will lead to the best treatment response for individual patients. We will perform the first head-to head comparison trial of the sequence of therapy with IDH-directed versus non- IDH-directed small molecule inhibitors for newly diagnosed, older IDH-mutated AML patients, complemented by the analysis of the largest to-date cohort of IDH-mutated AML patients to delineate clinical and molecular predictors of treatment response to different frontline therapies, including cytotoxic chemotherapy and small molecule inhibitors, which will be complemented by the integrated analysis of our large longitudinal patient collection. We hypothesize that these data analyses will characterize therapy-associated molecular treatment response patterns, with the overarching goal to provide data-driven support for for molecular-based treatment choices that improve outcomes of IDH-mutated AML patients.

PI_NAMEs: EISFELD, ANN-KATHRIN  (contact);MARDIS, ELAINE R;MIMS, ALICE SCOTT

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Address;Adult Acute Myeloblastic Leukemia;Age;analytical method;Automobile Driving;Biological;biomarker identification;Cancer Center;Cell Differentiation process;Cells;Characteristics;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;clinical practice;Clinical Trials;clinically relevant;Clonal Evolution;cohort;Collaborations;Collection;Combined Modality Therapy;compare effectiveness;Correlative Study;cytotoxic;Cytotoxic Chemotherapy;Data;Data Analyses;Decision Making;design;Diagnosis;Disease;Disease Progression;Disease remission;Dissection;DNA;drug mechanism;Drug resistance;Enzymes;Epigenetic Process;epigenome;Evolution;exome sequencing;experience;FDA approved;Future;Gene Expression;Gene Mutation;Genetic;Genetic Anticipation;Genetic Complementation Test;Genome;genomic profiling;Genomics;Genotype;Goals;head-to-head comparison;Hematopoietic;Histones;human old age (65+);Hypermethylation;Impairment;improved outcome;in vivo;individual patient;individualized medicine;Induction of Apoptosis;inhibitor;insight;Investigation;leukemia;leukemia treatment;liquid biopsy;Mediating;Methylation;Modality;Modeling;Modernization;Molecular;Molecular Abnormality;Molecular Profiling;mouse model;mutant;Mutate;Mutation;Neoadjuvant Therapy;Newly Diagnosed;novel;Oncology;Outcome;Outcome Assessment;Outcome Study;Pathway interactions;Patients;Pattern;personalized medicine;precision medicine;predicting response;Prediction of Response to Therapy;Production;Prognosis;programs;Prospective cohort;Regimen;Relapse;Research Personnel;Residual Neoplasm;Resistance;response;Retrospective cohort;risk stratification;Role;sample collection;Sampling;skills;small molecule;small molecule inhibitor;targeted agent;targeted treatment;Therapeutic;therapy resistant;transcriptome sequencing;translational study;treatment choice;Treatment Efficacy;Treatment Failure;Treatment outcome;Treatment Protocols;treatment response

PROJECT_TITLE: Understanding Treatment Response Patterns And Therapy Resistance In IDH-Mutant AML

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: LEY, KLAUS F. (contact)

PROJECT_TERMS: Address;Affinity;Bacterial Infections;Binding;Binding Sites;Biochemical;Biological Assay;Blood Platelets;Blood Vessels;Bone Marrow;Bone Marrow Stem Cell Transplantation;Cell Adhesion Inhibition;Cell membrane;Cell surface;Cells;chemokine;chemokine receptor;Chimeric Proteins;Collaborations;Confocal Microscopy;CXCR;Cytoplasmic Tail;Cytosol;Data;dimer;Dimerization;Disease;Dissociation;Epitopes;experimental study;Extracellular Domain;Flow Cytometry;Fluorescence Resonance Energy Transfer;G-protein Beta gamma;gain of function;Genes;Genetic;Grain;Hematopoietic stem cells;Hemorrhage;Hemostatic function;HL-60 Cells;Human;human disease;humanized mouse;IL8 gene;Image;In Vitro;in vivo;in vivo evaluation;Individual;Infection;Inflammation;Integrins;intravital microscopy;Knock-in Mouse;Knock-out;Label;Leukocyte Adhesion Deficiency;Leukocytes;Life;Ligands;light microscopy;live cell imaging;loss of function;Macrophage-1 Antigen;Mediating;Membrane;Microfluidics;Microscopy;Modeling;Molecular;Molecular Conformation;Monitor;Monoclonal Antibodies;Mus;Mutation;Names;nanometer;neutrophil;Optics;P-selectin ligand protein;Patients;PH Domain;phosphatidylinositol 3-kinase gamma;promoter;Protein Subunits;Proteins;quantitative imaging;reconstitution;reconstruction;recruit;Reporter;Reporting;Research Personnel;Resolution;retroviral transduction;Role;Selectins;sharpin;shear stress;Signal Pathway;Site;stem cells;Structure;superresolution imaging;superresolution microscopy;System;Talin;Testing;Thrombosis;Time;Tissues;tool;Transgenic Mice;Vascular Endothelium;vector;Visualization;Work

PROJECT_TITLE: Mechanism of kindlin-3-dependent integrin activation


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases

PHR: Narrative A seasoned team will elaborate on extracellular vesicles released from glioblastoma for use as biomarkers of clinical response. Studies will focus on how these extracellular vesicles subjugate normal cells in the microenvirons in support of tumor growth, and how these insights can be exploited to design novel modes of therapy.

PI_NAMEs: BREAKEFIELD, XANDRA OWENS (contact)

PROGRAM_OFFICER_NAME: SALOMON, RACHELLE

PROJECT_TERMS: Adaptive Immune System;anti-microbial peptide;Area;arm;Astrocytes;Biological Markers;Brain;brain cell;Cell Communication;Cell Therapy;cell type;Cells;Cessation of life;Clinical;combinatorial;Cross Presentation;Cytoplasm;Cytotoxic T-Lymphocytes;Dependovirus;design;Disease;DNA cassette;Early Diagnosis;Endowment;Evaluation;exhaust;extracellular vesicles;forging;Glioblastoma;Goals;Infiltration;Innate Immune System;insight;Life Support Systems;Ligands;Macrophage;Malignant Neoplasms;Microglia;Morbidity - disease rate;neoplastic cell;Neurosurgeon;Normal Cell;novel;novel therapeutics;Nucleic Acids;Phenotype;Plasma;programs;promoter;Proteins;Research Personnel;response;RNA;Seasons;Serum;standard of care;T-Lymphocyte;Therapeutic;tumor;Tumor Antigens;tumor growth;tumorigenic;vector;Vesicle;vesicular release

PROJECT_TITLE: The power of extracellular vesicles in glioblastoma


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Hematology;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: SHATTIL, SANFORD J (contact)

PROJECT_TERMS: Adaptor Signaling Protein;Adhesives;Agonist;angiogenesis;Binding;Blood Platelets;Blood Vessels;cadherin 5;CD40 Ligand;Cell Physiology;Cells;Collaborations;Complex;conditional knockout;Cytoplasmic Tail;Development;Endothelial Cells;Fibrinogen;Fibrinogen Receptors;Hemostatic Agents;Hemostatic function;Human;human induced pluripotent stem cells;Immune;Immune signaling;Immunity;in vivo;induced pluripotent stem cell;Inflammation;Inflammatory;insight;Integrin alpha Chains;Integrin alphaVbeta3;Integrins;interest;knock-down;Knock-out;Knockout Mice;Lentivirus;Link;Lipopolysaccharides;LoxP-flanked allele;lung microvascular endothelial cells;Mediating;Megakaryocytes;MHC Class I Genes;Modeling;mouse model;Mus;NFKB Activation Pathway;NFKB Signaling Pathway;optogenetics;overexpression;Partner in relationship;Pathologic Neovascularization;Pathway interactions;Platelet aggregation;platelet function;Platelet Membrane Glycoprotein IIb;preservation;programs;Proteins;Regulation;Research;response;Role;Signal Pathway;Signal Transduction;small hairpin RNA;stoichiometry;Tail;Talin;Techniques;Testing;Thrombin;Thrombosis;tool;Tumor Angiogenesis;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Western Blotting

PROJECT_TITLE: Role of SHARPIN in the Adhesive and Inflammatory Functions of Platelets and Endothelial Cells