NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Prevention;Rare Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: BEST, SONJA  (contact)

PROJECT_TERMS: adaptive immune response;Affect;Alkhurma Virus;Amino Acids;Animal Model;Anti-viral Response;Antigen Presentation;Area;arthropod-borne;Automobile Driving;B-Cell Activation;Biology;burden of illness;Capsid;Categories;CD4 Positive T Lymphocytes;Cell Physiology;Cell Survival;Cells;Central Nervous System Infections;Characteristics;chemokine;Clinical;Complex;Coronavirus;Culicidae;cytokine;Cytotoxic T-Lymphocytes;Dendritic Cells;Dengue Virus;Development;Electron Transport;Endoplasmic Reticulum;Event;Flavivirus;Flavivirus Infections;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;Goals;Growth;hemorrhagic fever virus;Host resistance;Hour;Human;human pathogen;Hyperactivity;Immune;immune activation;Immune Evasion;Immune response;Immune system;Immunity;improved;Infection;Inflammation Mediators;Inflammatory Response;innate immune mechanisms;Innate Immune Response;Interferon alpha;Interferon Type I;Interferons;Janus kinase;Japanese encephalitis virus;Kyasanur Forest disease virus;Laboratories;Ligation;Macaca mulatta;Macrophage;member;Membrane;Metabolic;Methyltransferase;Mitochondria;Modeling;mosquito-borne;mouse model;National Institute of Allergy and Infectious Disease;Natural Immunity;neutralizing antibody;Nonstructural Protein;novel;Nuclear;Nucleic Acids;Open Reading Frames;pathogen;Pathogenesis;pathogenic virus;Pathway interactions;Pattern recognition receptor;Peptide Hydrolases;Persons;Polyproteins;prevent;programs;Proteins;Reactive Oxygen Species;receptor;Receptor Signaling;Research;Resistance;Respiration;response;Retroviridae;RNA;RNA Processing;RNA Viruses;RNA-Directed RNA Polymerase;Role;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Site;success;T-Lymphocyte;Therapeutic;Tick-Borne Encephalitis;Tick-Borne Encephalitis Virus;tick-borne flavivirus;Ticks;Toll-like receptors;transcription factor;Transcriptional Activation;Transducers;Translating;transmission process;Tretinoin;TRIM Gene;TRIM Motif;vaccine effectiveness;Vaccinee;Vaccines;Viral;Viral Hemorrhagic Fevers;Viral Pathogenesis;Viremia;Virulent;Virus;Virus Diseases;virus host interaction;Virus Replication;West Nile virus;Work;Yellow Fever;Yellow Fever Vaccine;Yellow fever virus;Zika Virus

PROJECT_TITLE: Virus-Host Interactions: Induction and Evasion of Host Innate Immunity


ACTIVITY: ZIA

ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Hematology;Infectious Diseases;Rare Diseases

PI_NAMEs: KLION, AMY  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Affect;Aftercare;Allergens;Allergic;Angioneurotic Edema;Asthma;Automobile Driving;Barbering;Benign;Blocking Antibodies;Blood;Bone Marrow;Cells;Chemotaxis;Clinical;clinical subtypes;cohort;Collaborations;conventional therapy;COVID-19;Data;diagnostic tool;Disease;Disseminated eosinophilic collagen disease;effective therapy;Effector Cell;Enrollment;eosinophil;Eosinophilia;Eosinophilic leukemia;Eotaxin;Failure;Fasciitis;Filariasis;Follow-Up Studies;fusion gene;Goals;helminth infection;Homeostasis;Human;human disease;Hypersensitivity;Imatinib;Immune response;improved;Infection;interest;Interleukin 4 Receptor;Interleukin-5;investigator-initiated trial;Longterm Follow-up;Lung;Lung infections;Lymphocyte;Mediating;mepolizumab;microbial;migration;Monoclonal Antibodies;mouse model;Mycobacterium tuberculosis;Myelogenous;neoplastic;neutrophil;novel;novel diagnostics;Organ;participant enrollment;pathogen;Pathogenesis;Pathway interactions;patient subsets;Patients;PDGFRA gene;Periodicity;Peripheral;peripheral blood;Peripheral Blood Eosinophilia;phase III trial;Phenotype;Pilot Projects;Population Characteristics;predicting response;Production;Pulmonary Eosinophilia;Rare Diseases;Reaction;recruit;Refractory;response;Role;SARS-CoV-2 infection;Serum;Serum Markers;Site;Steroids;Study of serum;Symptoms;targeted treatment;Therapeutic Agents;Tissues;Tyrosine Kinase Inhibitor;Universities;Variant

PROJECT_TITLE: Eosinophils and Eosinophil Activation in the Pathogenesis of Human Disease


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PI_NAMEs: MULJO, STEFAN  (contact)

PROJECT_TERMS: 3' Untranslated Regions;Ablation;ATAC-seq;Attention;Autoimmune Diseases;Autoimmunity;Biogenesis;Biological;Biological Models;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Reprogramming;Cells;Cleavage Under Targets and Release Using Nuclease;Communicable Diseases;crosslinking and immunoprecipitation sequencing;Data;Dedications;deep sequencing;Diagnosis;Dicer Enzyme;Disease;disease model;DNA;dynamic system;Exhibits;fundamental research;Gene Expression;Genetic;Genetic Code;Genetic Transcription;Genetically Engineered Mouse;genome wide methylation;Genomics;Goals;Health;Helper-Inducer T-Lymphocyte;Hematopoietic System;histone methylation;Human;Hypersensitivity;Immune response;Immune system;Immunity;Immunobiology;immunodeficiency;immunopathology;improved;insight;interest;Knowledge;Laboratories;Lymphocyte;Malignant lymphoid neoplasm;Malignant Neoplasms;Mammals;Maps;Massive Parallel Sequencing;Messenger RNA;Methods;MicroRNAs;Mining;mouse genetics;mouse model;novel;Pattern;Performance;Play;Post-Transcriptional Regulation;posttranscriptional;programs;Proteins;Publications;Research;RNA;RNA-Binding Proteins;RNA-Induced Silencing Complex;Role;Signal Pathway;System;T-Lymphocyte;Techniques;Testing;Th1 Cells;tool;transcriptome;transcriptome sequencing;Untranslated RNA;Work

PROJECT_TITLE: Roles of non-Coding RNAs in Programming Lymphocyte Differentiation and Function


PI_NAMEs: BELKAID, YASMINE  (contact)

PROJECT_TITLE: Role of Tissue-Specific Factors in the Control of Immunity


PROJECT_TERMS: Antigen-Presenting Cells;Caloric Restriction;Cell Physiology;Cells;Cues;Development;immune function;Immune system;immune system function;Immunity;Infection;Macronutrients Nutrition;Malnutrition;Metabolic;microbiota composition;Micronutrients;Nutrient;nutrition;Nutritional;oral tolerance;Population;response;Role;Stress;T-Lymphocyte;Vaccines;Work

PROJECT_TITLE: Role of nutrition in the Control of Immunity


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: DUFFY, PATRICK  (contact)

PROJECT_TERMS: Africa;African;Animals;Antibodies;Antigens;Cell Communication;Child;Chromosomes;Complex;Country;efficacy evaluation;Encapsulated;Erythrocytes;frontier;Genes;Genetic;genomic epidemiology;Genomic Segment;Human;Immune response;Immunization;Immunology;In Vitro;Infection;inhibiting antibody;Integration Host Factors;Invaded;Lipids;Malaria;Malaria Vaccines;Merozoite Surface Protein 1;Messenger RNA;Methods;Microbe;Mus;Names;nonhuman primate;offspring;Outcome;Parasitemia;Parasites;Pathogenesis;plasmid DNA;Plasmodium falciparum;Plasmodium falciparum genome;Population Study;Pregnancy;Prevention;Proteins;Proteome;Publications;Recombinant Proteins;Reporting;Resistance;Sampling;Scientist;screening;vaccine development;vaccine discovery;Variant;Work

PROJECT_TITLE: Malaria Pathogenesis in young children and vaccine discovery


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PROJECT_TERMS: Adult;Animal Model;Animals;Anti-malarials;Antibodies;Antibody titer measurement;Antigen Targeting;Antigens;Binding;booster vaccine;CD8B1 gene;Cells;child bearing;Clinical;Communicable Diseases;Conceptions;Dose;double-blind placebo controlled trial;efficacy evaluation;Erythrocytes;Evaluation;Extracellular Domain;Flow Cytometry;Goals;Human;Hybridomas;Immune;Immune response;Immunity;Immunize;Infection;Malaria;malaria infection;Mali;Mammalian Cell;Monoclonal Antibodies;Mus;novel;Parasites;Peptides;Phase;Placebo Control;Plasmodium falciparum;Plasmodium falciparum vaccine;Pregnancy;Progress Reports;protective efficacy;Proteins;Publications;Randomized;Randomized, Controlled Trials;Rattus;receptor;Recombinant Proteins;Reporting;response;Safety;Sampling;Serology;Sorting;Specificity;Surface;T-Lymphocyte;Technology;Testing;Vaccination;vaccine candidate;vaccine efficacy;vaccine trial;vaccine-induced antibodies;Vaccines;Variant;Woman;Work

PROJECT_TITLE: Evaluation of Novel Preerythrocytic Anti-infection Malaria Vaccine Candidates


PI_NAMEs: MCBRIDE, ALISON  (contact)

PROJECT_TERMS: Area;autoinflammatory diseases;Cells;clinical center;Communicable Diseases;Epithelial Cells;Fibroblasts;gene therapy;Genetic;Genetic Diseases;Goals;Human;Individual;inhibitor;Investigation;keratinocyte;Research;Rho-associated kinase;Source;Techniques;United States National Institutes of Health;Virus

PROJECT_TITLE: Efficient Immortalization of Primary Human Keratinocytes


PROJECT_TERMS: Adult;aged;Anti-malarials;Antibodies;Antibody Response;Area;Binding;booster vaccine;CD3 Antigens;CD4 Positive T Lymphocytes;child bearing;Church;Clinical;clinical investigation;co-infection;cohort;Communicable Diseases;Complement;Conceptions;Deposition;Dose;double-blind placebo controlled trial;exhaustion;follow-up;Hepatocyte;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;Human;Immune response;Immunization;Immunization Programs;Immunosuppression;Individual;Invaded;Journals;Malaria;malaria infection;malaria transmission;Mali;Mass Vaccinations;Measures;Participant;Phase;Placebos;Plasmodium falciparum;Plasmodium falciparum vaccine;Population;Pregnancy;protective efficacy;Publishing;Randomized;Randomized, Controlled Trials;Regulation;Regulatory T-Lymphocyte;response;Safety;safety assessment;Saline;Schedule;Seasons;Site;Sporozoites;Sterility;T cell response;T-Lymphocyte;Vaccination;vaccine efficacy;vaccine immunogenicity;vaccine response;vaccine trial;Vaccinee;Vaccines;Woman;Work;γδ T cells

PROJECT_TITLE: T Cell Regulatory and Suppression Mechanisms in Malaria


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Lung;Malaria;Neurosciences;Prevention;Rare Diseases;Sickle Cell Disease;Vector-Borne Diseases

PI_NAMEs: ACKERMAN, HANS  (contact)

PROJECT_TERMS: 2019-nCoV;Abdomen;ACE2;Adipose tissue;Adult;alpha Globin;alpha-Thalassemia;Animal Model;Arginine;Arteries;Atherosclerosis;Bacteria;beta Globin;Biochemical;Biological Availability;Biological Models;Biology;Biopsy;Black race;Blood;Blood Circulation;Blood Pressure;blood pressure medication;Blood Vessels;Brain;Brain Edema;Brazil;Calcium Signaling;Cardiovascular Physiology;Cardiovascular system;Cells;Cerebral cortex;Cerebral Malaria;Cessation of life;Child;Chronic;clinical center;clinical investigation;Coculture Techniques;cofactor;Collaborations;Coma;Complex;COVID-19;COVID-19 pandemic;COVID-19 treatment;CRISPR/Cas technology;Data;design;Diffusion;Disease;Drainage procedure;Early Diagnosis;Education;Endothelial Cells;endothelial dysfunction;Endothelium;Erythrocytes;Exercise;Exhalation;Extramural Activities;Functional disorder;Future;Gap Junctions;Gene Deletion;Gene Proteins;Gene Silencing;Genes;Genetic;Genetic Variation;Genomics;Germ Lines;Globin;Glycosylated hemoglobin A;grasp;Guide RNA;Hand;Hemoglobin;Hospitalization;Hospitals;Human;human model;Impairment;improved;In Vitro;in vivo;Individual;Inflammation;Inhalation;Inherited;intercellular communication;Intercellular Junctions;interest;Internal Medicine;Interruption;Intervention Studies;Intravenous;Investigation;Kidney Diseases;knock-down;Knock-out;Knowledge;Laboratories;Lead;Learning;Liquid substance;Lisinopril;Lung;Lung Diseases;Magnetic Resonance Imaging;Malaria;Malawi;Mali;Measures;Metabolic;Modeling;Modification;mouse model;Mus;Mutation;National Institute of Allergy and Infectious Disease;Near-Infrared Spectroscopy;Nitric Oxide;Nitric Oxide Synthase;Nitric Oxide Synthetase Inhibitor;NOS3 gene;novel marker;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Organ;Orthostasis;Parasites;Pathogenesis;Patients;Perfusion;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Physiology;Populations at Risk;Porosity;Prevention;programs;Proteins;Published Comment;pulmonary function;receptor;Recombinants;Regulation;Renal Blood Flow;Research;response;Resuscitation;Role;Severity of illness;Sickle Cell;Sickle Cell Anemia;Sickle Cell Trait;Side;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;Specificity;Stem cell transplant;Stimulus;subcutaneous;Technology;Testing;tetrahydrobiopterin;Therapeutic;Time;Tissues;Translating;transmission process;treatment center;United States National Institutes of Health;Universities;Variant;Vascular Diseases;Vascular Endothelium;Vascular Smooth Muscle;vasoconstriction;Vasodilation;Veins;Venous;Viral Load result;Virginia;virology;Virus;Work

PROJECT_TITLE: Nitric Oxide and Endothelial Function in Patients with Malaria


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Infectious Diseases;Malaria;Maternal Health;Pediatric;Pregnancy;Rare Diseases;Vector-Borne Diseases;Women's Health Research

PI_NAMEs: FRIED, MICHAL  (contact)

PROJECT_TERMS: Adhesions;Antibodies;Antigens;Binding;bioinformatics tool;Biological Assay;Biological Markers;Birth;Blood Platelets;Blood specimen;CD36 gene;Child;Chondroitin Sulfate A;Clinical;cohort;density;Development;Disease;Disease Pathway;Enrollment;follow-up;Genes;Genetic;Genetic Variation;Genets;genome wide association study;Goals;Heritability;Humoral Immunities;Immune response;Immunity;Immunoprecipitation;improved;Infection;Introns;Malaria;malaria infection;Mali;Measures;Mediating;Mediator;Membrane;Membrane Proteins;Newborn Infant;novel;Parasites;Pathogenesis;Phenotype;Placenta;Plasmodium falciparum;Platelet Count measurement;PPBP gene;Predisposition;Pregnancy;Pregnancy loss;Pregnancy Outcome;Pregnant Women;Premature Birth;Proteins;Proteome;Proteomics;Publications;Recombinants;Reporting;Risk;Role;Severity of illness;Surface;System;Time;tool;Variant;Woman

PROJECT_TITLE: Malaria Pathogenesis in Pregnant Women and Young Children


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Patient Safety;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: CROMPTON, PETER  (contact)

PROJECT_TERMS: acquired immunity;adaptive immune response;Address;Adult;Africa;aged;Anti-malarial drug resistance;Anti-malarials;Antibodies;Antibody Response;Antigens;Area;Artemisinins;Beds;Biology;Child;Clinical Data;Clinical Trials;Cohort Studies;Collaborations;Combined Modality Therapy;Communicable Diseases;Computational Biology;Country;Culicidae;Data;Development;Double-blind trial;Drug Controls;Entomology;Epidemiology;experience;Exposure to;Falciparum Malaria;Future;Genomics;Geographic Locations;Healthcare;Human;human monoclonal antibodies;Immune;Immune response;Immune system;Immunity;Immunologics;Immunology;Individual;Infant;Infection;Inflammation;Infrastructure;Innate Immune Response;Insecticide Resistance;Insecticides;insight;Intervention;Kinetics;Knowledge;Life Cycle Stages;Longitudinal cohort study;Maintenance;Malaria;malaria transmission;Malaria Vaccines;Mali;Molecular;Molecular Profiling;Monoclonal Antibodies;National Institute of Allergy and Infectious Disease;Observational Study;optimism;Parasites;phase III trial;Plasmodium falciparum;Play;Population;Pregnancy;prevent;Public Health;Randomized;Risk;safety testing;Science;Scientist;Seasons;Site;Specificity;Systems Biology;Techniques;Technology;technology/technique;tool;Translating;Universities;vaccine-induced antibodies;Vaccines;vector control;Work

PROJECT_TITLE: Mechanisms of naturally-acquired immunity to malaria


NIH_SPENDING_CATS: Cancer;Clinical Research

PI_NAMEs: JIN, TIAN  (contact)

PROJECT_TERMS: Actins;Bacteria;cancer cell;cell motility;Cells;chemokine;chemokine receptor;Chemotactic Factors;Chemotaxis;cofilin;Coupled;Defect;Escherichia coli;Exhibits;fighting;fMet-Leu-Phe receptor;G-Protein-Coupled Receptors;Goals;GTP-Binding Proteins;Human;Human body;IL8 gene;Immobilization;Immune;Immunoglobulin G;Invaded;Mediating;migration;Molecular;Mus;Natural Immunity;Neoplasm Metastasis;neutrophil;Opsonin;Phagocytes;Phagocytosis;Phosphorylation;polymerization;Polymers;Protein Tyrosine Kinase;Proto-Oncogene Proteins c-akt;receptor;response;Signal Transduction;Surface;trafficking;Work

PROJECT_TITLE: The Mechanisms Involved in Chemotaxis of Immune and Cancer Cells


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

PI_NAMEs: MEMOLI, MATTHEW  (contact)

PROJECT_TERMS: 1918 influenza pandemic;Adult;Avian Influenza A Virus;Cessation of life;Child;Clinical Protocols;Clinical Research;Collaborations;COVID-19 pandemic;COVID-19 vaccination;Development;diagnostic tool;Enrollment;Epidemic;Family suidae;Goals;Human;human pathogen;Human Volunteers;Immunity;Individual;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;Influenza B Virus;influenza epidemic;influenza infection;Influenza vaccination;influenzavirus;Investments;Longitudinal Studies;manufacture;Modeling;Morbidity - disease rate;mortality;Mucosal Immunity;Mucous Membrane;National Institute of Allergy and Infectious Disease;Natural History;novel;novel therapeutics;novel vaccines;novel virus;pandemic disease;pandemic influenza;Pathogenesis;patient population;Persons;post-COVID-19;post-pandemic;pre-pandemic;previous pandemic;Process;programs;Protocols documentation;Public Health;Publishing;response;seasonal influenza;Serology;Switzerland;System;Therapeutic;Translational Research;vaccine strategy;Virus;Virus Diseases;volunteer;Work

PROJECT_TITLE: Pandemic Influenza Translational Research and novel universal countermeasure development


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: WHITEHEAD, STEPHEN  (contact)

PROJECT_TERMS: 12 year old;17 year old;4 year old;Acceleration;Admixture;Adolescent;Adult;Age;age group;Agreement;antibody test;Area;Attenuated;Attenuated Vaccines;Biological Assay;Cellular Immunity;Child;Clinical;Clinical Research;Clinical Trials;cohort;Controlled Clinical Trials;COVID-19;Data;Databases;Dengue;Dengue Vaccine;Dengue Virus;Dengvaxia;Dose;Double-Blind Method;efficacy trial;Enrollment;Evaluation;experience;Flavivirus;follow-up;Funding;Genetic;Goals;Human;Immune response;Immunity;immunogenicity;Individual;Infant;Manuscripts;Medical Research;National Institute of Allergy and Infectious Disease;Phase;phase 2 study;Placebo Control;Process;Program Evaluation;programs;Publications;Published Comment;Publishing;Safety;Sampling;Sampling Studies;Serology test;Thailand;Vaccination;vaccine candidate;Vaccinee;Vaccines;Viremia;Virus;Work;Writing

PROJECT_TITLE: CAP:Evaluation of a Dengue Vaccine in Adults with Preexisting Flavivirus Immunity


NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Genetics;Immunotherapy;Infectious Diseases

PI_NAMEs: ZHU, JINFANG  (contact)

PROJECT_TERMS: adaptive immune response;Address;Affect;Allergic Disease;Amino Acids;Antigen Receptors;Asthma;Autoimmune Diseases;Autoimmunity;Bacteria;Binding Sites;Biology;BLR1 gene;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Lineage;Cell Physiology;cell type;Cells;chronic infection;Classification;Collaborations;Complex;CRISPR/Cas technology;cytokine;Data;Development;Disease;DNA;DNase I hypersensitive sites sequencing;draining lymph node;effector T cell;Elements;Enhancers;epigenomics;extracellular;Failure;Female;Follow-Up Studies;FOXP3 gene;frontier;fungus;GATA3 gene;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Health;Helminths;Helper-Inducer T-Lymphocyte;Heterogeneity;Heterozygote;Host Defense;Hypersensitivity;IL17 gene;Immune;Immune response;Immunity;Immunodysregulation polyendocrinopathy enteropathy X-linked syndrome;Immunology;immunoregulation;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Interferon Type II;Interleukin-13;Interleukin-2;interleukin-22;Interleukin-4;Interleukin-5;Knock-in;Knock-in Mouse;Knockout Mice;Locus Control Region;Lymphocyte;Lymphoid;Lymphoid Cell;Lymphoid Tissue;male;Manuscripts;Mediating;microorganism;migration;Molecular;Mouse Strains;Multiple Sclerosis;Mus;Mutant Strains Mice;Mutation;National Center for Advancing Translational Sciences;Natural Killer Cells;novel;Organ;Organogenesis;Papain;Parasite Control;Parasites;pathogen;Pathogenesis;pathogenic microbe;Pathologic;Pathology;Pathway interactions;Patients;Play;Population;Process;Production;Proteins;Regulation;Regulatory Element;Regulatory T-Lymphocyte;Reporter;Reporting;Research;response;Rheumatoid Arthritis;Role;Self Tolerance;Signal Transduction;Site;Structure of germinal center of lymph node;Structure of parenchyma of lung;T cell differentiation;T-Cell Activation;Th1 Cells;Th2 Cells;Tissues;tool;Toxoplasmosis;transcription factor;transcription regulatory network;Transcriptional Regulation;transcriptome;transcriptomics;Up-Regulation;Virus;Work

PROJECT_TITLE: Transcriptional Regulation of Immune Cell Development, Activation and Functions


PROJECT_TERMS: Adult;Adverse event;Africa;African;aged;Anti-malarials;Antibodies;Attenuated;Binding;Bite;CD3 Antigens;CD4 Positive T Lymphocytes;Chemoprophylaxis;child bearing;Chloroquine;Church;circumsporozoite protein;Clinical;clinical investigation;Clinical Trials;Collaborations;Communicable Diseases;Complement;Conceptions;Cryopreservation;Culicidae;Deposition;design;Dose;double-blind placebo controlled trial;Good Manufacturing Process;Hepatocyte;HIV;HIV Seronegativity;HIV Seropositivity;Human;Immunity;Immunization Programs;immunogenicity;Individual;intravenous administration;Invaded;Journals;Malaria;malaria infection;Mali;man;manufacturing process;Mass Vaccinations;Mus;National Institute of Allergy and Infectious Disease;Needles;Participant;Phase;Placebos;Plasmodium falciparum;Pregnancy;primary outcome;Procedures;protective efficacy;Protocols documentation;Publications;Pyrimethamine;Radiation;Randomized;Randomized, Controlled Trials;Regimen;Reporting;Safety;safety assessment;Saline;Schedule;secondary outcome;Series;Sporozoite vaccine;Sporozoites;Sterility;Syringes;T cell response;T-Lymphocyte;Testing;United States National Institutes of Health;unpublished works;Vaccination;vaccine efficacy;vaccine safety;vaccine trial;Vaccinee;Vaccines;volunteer;Whole Organism;Woman

PROJECT_TITLE: Assessment of malaria whole organism vaccines


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cancer;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Skin Cancer;Tuberculosis

PI_NAMEs: BARBER, DANIEL  (contact)

PROJECT_TERMS: Adverse event;Animal Model;antigen-specific T cells;Autoimmune;Biological Products;cancer immunotherapy;cancer therapy;Case Study;Cause of Death;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;Cellular Immunology;Cessation of life;checkpoint inhibition;Chronic;Clinical;Clinical Trials;co-infection;CTLA4 gene;Cytomegalovirus;Cytomegalovirus Infections;Disease;Dose;efficacy testing;Enteritis;Equilibrium;Goals;HIV;Hodgkin Disease;Hospitalization;Human;Human Herpesvirus 8;immune checkpoint blockade;immunopathology;immunoregulation;in vivo;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;Infusion procedures;Intestines;Intra-abdominal;Kaposi Sarcoma;lymph nodes;Lymphocytic choriomeningitis virus;Lymphoid Tissue;Malignant Neoplasms;Merkel cell carcinoma;microbial;Modality;Modeling;mouse model;Mucous Membrane;Mus;Mycobacterium Infections;Mycobacterium tuberculosis;Mycoses;non-tuberculosis mycobacteria;non-tuberculous mycobacterial infection;nonhuman primate;novel;Outcome;Pain;pathogen;Pathogenicity;Pathology;Pathway interactions;patient population;Patients;PD-1 blockade;pembrolizumab;Peripheral;Persons;Pharmaceutical Preparations;Play;Primary carcinoma of the liver cells;programmed cell death protein 1;Property;Pulmonary Tuberculosis;Reaction;Regulatory Pathway;Research;Role;safety assessment;Site;T cell differentiation;T cell regulation;T cell response;T-Lymphocyte;Techniques;Tuberculosis;tumor;United States Food and Drug Administration;Viral;Virus;Virus Diseases;Work

PROJECT_TITLE: Immune Regulation in Mycobacterial and Fungal Infections


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Prevention;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: LIONAKIS, MICHAIL  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adaptive immune response;Affect;Agammaglobulinaemia tyrosine kinase;Alleles;Anatomy;Animal Model;anti-fungal agents;Antibiotics;Antifungal Therapy;Aspergillosis;Aspergillus;Aspergillus fumigatus;Autoimmune;Autoimmunity;autosome;Biological;Biological Process;Candida;Candidiasis;Cell Culture System;Cells;Cellular Immunity;Central Nervous System;Cessation of life;Chemotactic Factors;Chronic Granulomatous Disease;Chronic Mucocutaneous Candidiasis;Clinical;clinical center;Clinical Protocols;Clinical Trials;clinically relevant;cohort;Communicable Diseases;conditional knockout;congenital immunodeficiency;Critical Illness;Defect;Diagnosis;diagnostic criteria;Disease;disease phenotype;Disseminated candidiasis;DOCK8 deficiency;Event;Filament;Fungal Drug Resistance;gain of function mutation;Genetic;Genetic Polymorphism;Genetic Predisposition to Disease;genetic testing;genetic variant;Genomics;Germination;Goals;Hematopoietic Stem Cell Transplantation;Host Defense;Human;Hyphae;Iatrogenesis;imaging approach;Immune;immune activation;Immune response;Immunogenomics;Immunologics;immunosuppressed;Impairment;improved;In Vitro;in vivo;Infection;Inhalation;Inherited;Innate Immune Response;Integration Host Factors;interest;Knockout Mice;Knowledge;Laboratories;Laboratory Research;Laboratory Study;Lung;Macrophage;Malignant Neoplasms;Mediating;member;Molds;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Mus;mutant;Mutation;Mycoses;National Institute of Allergy and Infectious Disease;neutrophil;novel;novel strategies;Oral;Oral candidiasis;Organ;Outcome;pathogenic fungus;Patient Recruitments;Patients;Phagocytes;Pharmacotherapy;Polyglandular Autoimmune Syndrome Type I;Predisposition;Prevention approach;Prevention strategy;Process;programs;recruit;Respiratory Burst;Role;Sampling;Sepsis;Site;STAT1 gene;Syndrome;System;Testing;Tissues;trafficking;Transplant Recipients;treatment strategy;Tyrosine Kinase Inhibitor;United States;United States National Institutes of Health;vaginal candidiasis;Woman;Yeasts

PROJECT_TITLE: Immunopathogenesis of Fungal Infections


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Immunization;Infant Mortality;Infectious Diseases;Malaria;Malaria Vaccine;Maternal Health;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Women's Health Research

PROJECT_TERMS: Adhesions;Alleles;Anemia;Animals;Antibodies;Antigens;Aotus primate;Area;Binding;Birth;Blocking Antibodies;Chondroitin Sulfate A;Congenital Abnormality;cross reactivity;design;Elements;Enzyme-Linked Immunosorbent Assay;Erythrocytes;experimental study;Exposure to;fetal;Genitourinary system;Goals;Gravid;Gravidity;Human;Immune response;Immunity;Immunization;Immunize;inclusion criteria;Infant Mortality;inhibiting antibody;Journals;Length;Link;Literature;Low Birth Weight Infant;Malaria;malaria transmission;Malaria Vaccines;male;Mediating;Modeling;Molecular;Monkeys;Neonatal Mortality;nonhuman primate;obstetric outcomes;Outcome;Parasites;pathogen;Pathogenesis;phase I trial;Placenta;placental malaria;Plasmodium falciparum;Pre-Eclampsia;predictive modeling;Pregnancy;Pregnancy loss;Pregnancy Outcome;Pregnant Women;Premature Birth;prevent;Production;Prospective Studies;Proteins;Public Health;Publications;Reaction;receptor;receptor binding;Reporting;Residual state;Risk;Structure;Surface;systematic review;Testing;vaccination strategy;vaccine candidate;vaccine development;Vaccines;Variant;vector control;Woman

PROJECT_TITLE: Pregnancy Malaria Vaccine development


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Orthopoxviruses;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: MUNSTER, VINCENT  (contact)

PROJECT_TERMS: Aerosols;Air Movements;Animals;Arenavirus;Birds;Chiroptera;Communities;Coronavirus;cross-species transmission;Data;data exchange;Detection;Development;Disease;Disease Outbreaks;Disease Surveillance;Ebola virus;Ecology;emerging virus;Event;experimental study;Filovirus;foodborne;future outbreak;Genetic;Goals;Henipavirus;Human;Humidity;immunological status;infectious disease treatment;interest;Intervention;Knowledge;Link;medical countermeasure;Middle East Respiratory Syndrome Coronavirus;Modeling;Molecular;Monkeypox virus;Nipah Virus;novel;Orthobunyavirus;Orthomyxoviridae;Orthopoxvirus;pathogen;Pathogen detection;pathogenic virus;Pathogenicity;Prevalence;prevent;Prevention;Prevention strategy;programs;prophylactic;Public Health;receptor;Research;Resource-limited setting;Risk;Rodent;Route;Sampling;Serology;Site;Temperature;Therapeutic;Therapeutic Intervention;tool;transmission blocking;transmission process;Variant;Vertical Transmission;Virus;Virus Shedding;Work;Zoonoses

PROJECT_TITLE: Virus Ecology Unit


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Nanotechnology;Pneumonia and Influenza;Prevention;Vaccine Related

PI_NAMEs: HARRIS, AUDRAY  (contact)

PROJECT_TERMS: 1918 influenza pandemic;3-Dimensional;adaptive immune response;Address;Affect;alpha helix;Animals;Antibodies;Antigens;Architecture;Area;arm;Attenuated;B-Lymphocytes;Binding;Biochemical;Coin;Communicable Diseases;Competence;Complex;design;Development;Electron Microscopy;Engineering;Epitopes;Evaluation;Formulation;future pandemic;Geometry;Goals;Health;Hemagglutinin;Human;Immune response;Immune system;Immunity;immunogenicity;Immunologics;improved;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H7N9 Subtype;influenza outbreak;influenza virus vaccine;influenzavirus;Innate Immune Response;innovation;Investigation;Membrane Glycoproteins;Mission;Molecular;molecular modeling;nanoparticle;nanotechnology platform;Nature;neutralizing antibody;Nucleoproteins;pandemic disease;particle;Persons;Pharmaceutical Preparations;Phase;Population;Proteins;Public Health;Recombinants;Research;scaffold;Scaffolding Protein;Seasons;structural biology;Structure;Subunit Vaccines;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;transmission process;United States National Institutes of Health;universal influenza vaccine;vaccine formulation;Vaccine Production;Vaccines;Viral Vaccines;Virus;Virus-like particle;Work;Zoonoses

PROJECT_TITLE: Structural Biology of Influenza Epitopes


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Genetics;Hematology;Human Genome;Neurodegenerative;Pediatric;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PROJECT_TERMS: 3' Untranslated Regions;Ablation;Adult;Affect;Africa;Alternative Splicing;Amyotrophic Lateral Sclerosis;Asia;Autoimmune Diseases;Autoimmunity;autoinflammation;autoinflammatory;B-Lymphocytes;beta Thalassemia;Binding;Biogenesis;Birth;Blood;Bone Marrow;CD34 gene;Cell Culture System;Cell Reprogramming;cell type;Cells;Child;Clinic;Collaborations;Communicable Diseases;congenital immunodeficiency;CRISPR/Cas technology;crosslink;Data;Data Set;Development;Diagnosis;Disease;Ectopic Expression;Engineering;Erythroid;erythroid differentiation;familial amyotrophic lateral sclerosis;Family;fetal;Fetal Hemoglobin;Gene Cluster;Gene Expression;Gene set enrichment analysis;Genes;Genetic;Genetically Engineered Mouse;Genome;Genomics;Globin;Goals;Growth;Health;Hematological Disease;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hematopoietic System;Hemoglobin;Human;Human Cell Line;Hypersensitivity;Immune system;Immunobiology;immunodeficiency;immunopathology;Immunoprecipitation;improved;in utero;insight;interest;Introns;Investigation;Knowledge;Life;Lymphocyte;Malignant lymphoid neoplasm;Malignant Neoplasms;Mammals;Maps;Mediating;Medical;Messenger RNA;MicroRNAs;Molecular;Mus;Mutate;Mutation;National Institute of Diabetes and Digestive and Kidney Diseases;Nervous System Disorder;novel;Pathogenesis;Patients;Phenotype;Play;posttranscriptional;Primary Cell Cultures;progenitor;Programmed Instruction;programs;Property;Proteins;Public Health;Regulation;Reporting;Research;Ribonucleosides;RNA;RNA-Binding Proteins;Role;Science;Shapes;Sickle Cell Anemia;Tertiary Protein Structure;Therapeutic;Transcript;Transcriptional Regulation;transcriptome;transcriptome sequencing;Untranslated RNA;Work

PROJECT_TITLE: Roles of RNA-binding Proteins in Programming Gene Expression in Mammals


NIH_SPENDING_CATS: Clinical Research;Orphan Drug;Rare Diseases

PI_NAMEs: SU, HELEN  (contact)

PROJECT_TERMS: Adenosine;Adult;Affect;Allergic;Autoimmune;Behavioral;Binding;Biological Response Modifiers;Body System;Case Study;cell behavior;cell growth regulation;Cells;Collaborations;Complex;Congenital disorders of glycosylation;congenital immunodeficiency;Cyclosporine;Defect;Disabling;Disease;Divalent Cations;Drug Targeting;Epstein-Barr Virus Infections;Equilibrium;Eukaryotic Cell;Exhibits;Experimental Animal Model;Genes;glycosylation;Graft Rejection;Human Herpesvirus 4;immune function;Immune response;Immunity;immunodeficiency;Immunosuppressive Agents;in vivo;Individual;Inositol;insight;Ions;Link;loss of function mutation;Lymphocyte Activation;Magnesium;Magnesium Deficiency;magnesium ion;Malignant Neoplasms;Mammalian Cell;Measures;Mediator;Modeling;Molecular;Mus;Names;Neoplasms;Nerve Degeneration;Neurologic;novel therapeutics;Nucleic Acids;Organism;Pathogenicity;Pathway interactions;Patients;Pharmacologic Substance;Phospholipids;Physiological;PLC gamma1;Production;Proteins;Recurrence;Regulation;response;Role;Second Messenger Systems;Stimulus;Symptoms;T-Lymphocyte;T-Lymphocyte and Natural Killer Cell;Testing;Time;tool;tripolyphosphate;Update

PROJECT_TITLE: New Roles of Magnesium as a Regulatory Ion in Immune Responses and Cell Behavior


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: FELDMANN, HEINRICH  (contact)

PROJECT_TERMS: Africa;Animal Model;Animals;antibody detection;Antigens;Arenavirus;Arthropods;Bacteria;Biological Assay;Cell Culture System;Circulation;Clinical Trials;clinically relevant;cohort;Collaborations;Collection;Communities;Coronavirus;Country;Crimean-Congo Hemorrhagic Fever Virus;Data;detection assay;Development;Disease;Ecology;emerging virus;Ensure;Enzyme-Linked Immunosorbent Assay;Epidemiology;Equipment;Etiology;experience;Extramural Activities;Fever;field study;Filovirus;Fishes;Flavivirus;Funding;global health;Health;Human;Immunity;In Vitro;in vivo;Individual;insight;instrument;interest;International;international center;Intervention;Laboratories;Lassa virus;Link;Livestock;Manuscripts;Microbiology;Modernization;Molecular;National Institute of Allergy and Infectious Disease;operation;Orthobunyavirus;Participant;pathogen;pathogenic bacteria;Population;Population Surveillance;Postbaccalaureate;postgraduate education;preclinical study;Preparation;programs;Public Health;Reader;Research;Research Institute;Research Personnel;Resources;Rift Valley Fever;Rift Valley fever virus;Risk Assessment;RNA vaccine;Rodent;Role;Sampling;Schedule;Schools;screening;Serology;Serology test;seropositive;Seroprevalences;Serum;Site;Students;Surveillance Program;Therapeutic;tick-borne pathogen;Training;Training and Education;training opportunity;transmission process;Uganda;United States National Institutes of Health;Universities;Vaccines;vector;vector-borne pathogen;Viral;Virus;Zoonoses

PROJECT_TITLE: Uganda International Center for Excellence in Research


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Rare Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Animal Model;Animals;Arboviruses;Area;Arenavirus;Back;Bacteria;Blood;Borrelia;British;Camels;Cattle;chikungunya;Chikungunya virus;Clinical;Clinical Research;Contracts;Coronavirus;Coronavirus Infections;COVID-19;COVID-19 testing;Crimean-Congo Hemorrhagic Fever Virus;Cytomegalovirus;Dengue;Dengue Virus;Diagnostic;Diagnostic tests;Disease;Doctor of Philosophy;Ebola;Etiology;experience;experimental study;falls;Fever;field study;Filovirus;Flavivirus;Follow-Up Studies;Future;Genetic;Geographic Distribution;Geographic Locations;Hantavirus;Health;Hospitals;Human;human study;Immunoglobulin G;Incidence;infected vector rodent;Infection;infection rate;Influenza A Virus, H5N1 Subtype;Innate Immune Response;international center;Laboratories;Lassa;Lassa Fever;Lassa virus;Leptospira;Livestock;Lujo virus;Macaca fascicularis;Mali;Manuscripts;Maps;Marburgvirus;Mastomys;Medical;Medical Students;Methodology;Middle East Respiratory Syndrome Coronavirus;Molecular Biology;Monkeypox virus;Order Spirochaetales;Orthobunyavirus;Paramyxovirus;pathogen;pathogenic virus;Pathogenicity;Population;preclinical efficacy;Preclinical Testing;Prevalence;programs;Public Health;Publishing;Relapsing Fever;Reporting;Research;Respiratory Disease;response;Rift Valley Fever;Rift Valley fever virus;Rodent;Route;Sampling;Scientist;Serology;Seroprevalences;serosurvey;Serum;Site;Students;Technology;Testing;Time;Tissue Sample;Togaviridae;tool;Training;transmission process;Universities;vaccine evaluation;Vaccine Research;Vaccines;vector;vector vaccine;Vesicular stomatitis Indiana virus;Viral Antigens;Virulent;Virus;Virus Diseases;Virus Shedding;Work;ZIKA;Zika Virus;Zoonoses

PROJECT_TITLE: Mali International Center for Excellence in Research


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases;Orthopoxviruses;Rare Diseases;Vector-Borne Diseases

PROJECT_TITLE: International Research in Congo


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Eczema / Atopic Dermatitis;Food Allergies;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Sexually Transmitted Infections;Transplantation

PROJECT_TERMS: Affect;Allergic Disease;Asthma;Atopic Dermatitis;Autoimmunity;autosome;Collaborations;Diagnosis;Disease;DOCK8 deficiency;Eczema;Eosinophilia;Food Hypersensitivity;General Population;Goals;Health;Hematopoietic Stem Cell Transplantation;Herpesvirus Type 3;human disease;Human Papillomavirus;IgE;Immune;immunodeficiency;Infection;Infectious Skin Diseases;interest;Knowledge;Life;Lymphocyte;Lymphoma;Malignant Neoplasms;microbial;Molluscum contagiosum virus;Morbidity - disease rate;mortality;Mutation;Outcome;Pathogenesis;Patients;Recurrence;Refractory;Research Personnel;Serum;Simplexvirus;Skin;Squamous cell carcinoma;Syndrome;Vascular Diseases;Viral;Virus Diseases

PROJECT_TITLE: Understanding DOCK8 Function in Health and Human Disease


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

PI_NAMEs: DELEO, FRANK  (contact)

PROJECT_TERMS: Antibiotic Resistance;beta-Lactams;carbapenem resistance;carbapenemase;Community Healthcare;Community-Acquired Infections;comorbidity;Complement;Development;Enterobacteriaceae;Goals;health care settings;Hospitals;Immune response;immunoprophylaxis;Immunosuppression;Immunotherapy;Incidence;Individual;Infection;Innate Immune System;Klebsiella pneumoniae;Microbe;Molecular;Multi-Drug Resistance;neutrophil;novel therapeutic intervention;opportunistic pathogen;Organism;Phenotype;Phylogeny;Plasmids;Prevention approach;Resistance;resistant Klebsiella pneumoniae;Serum;success;United States;virtual;Virulence

PROJECT_TITLE: Basis for Success of Multidrug-Resistant Enterobacteriaceae


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: LEHMANN, TOVI  (contact)

PROJECT_TERMS: Address;Adult;Aedes;Africa;African;Alpha Virus;Altitude;Anopheles Genus;Arboviruses;Area;Asia;Behavioral;Biology;Blood;Cessation of life;Cities;climate change;Collaborations;Culex (Genus);Culicidae;Data;Databases;Dengue;Destinations;Deuterium;Diffusion;Disease;Disease Outbreaks;Disease Surveillance;Disease Vectors;disorder control;Distant;doctoral student;Dryness;Ecology;Ecosystem;Emerging Communicable Diseases;Environmental Wind;enzootic;Epidemiology;epizootic;experience;Female;filaria;Flavivirus;Florida;food security;forest;Frequencies;frontier;Ghana;Goals;Guinea;Health;Horns;Hour;improved;Infection;infection rate;Insecta;insight;Intercept;Invaded;Joints;Kenya;Knowledge;Leafhoppers;Link;literature survey;Location;Maintenance;Malaria;malaria mosquito;malaria transmission;male;Mali;Mansonia;Maps;Mediating;member;Migrant;migration;Molecular;Monitor;Mosquito Control;Mosquito-borne infectious disease;mosquito-borne pathogen;Movement;National Institute of Allergy and Infectious Disease;Nature;New Territories;Nigeria;novel;Orthobunyavirus;Paper;pathogen;Pattern;Physiological;Plasmodium;Population;Postdoctoral Fellow;predictive modeling;pressure;prevent;Prevention;Process;Public Health;Rain;Records;Reporting;Risk;Role;rural area;Sampling;Science;Seasons;Senegal;Site;Source;South American;Specimen;success;Surface;Technology;Time;Translating;transmission process;United States National Institutes of Health;Universities;urban area;Validation;vector;vector control;Vector-transmitted infectious disease;Vertebrates;Virus;Vision;Water;West Nile;Zoonoses

PROJECT_TITLE: Ecology of Disease Vectors


NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: LUSSO, PAOLO  (contact)

PROJECT_TERMS: Adopted;Affinity;Animals;Antibodies;Antibody Response;Antibody-mediated protection;Antigenic Variation;Antigens;autoreactivity;B-Cell Activation;Binding;Binding Sites;Biological;chimeric antibody;Clinical;Complex;Cryoelectron Microscopy;design;Development;disulfide bond;Dose;Engraftment;Epitopes;Evaluation;Family;Formulation;Framework Regions;Generations;Genes;Genetic Transcription;Germ Lines;Glycoproteins;glycosylation;Goals;Half-Life;High Prevalence;HIV;HIV Envelope Protein gp120;HIV Infections;HIV therapy;HIV vaccine;HIV-1;HIV-1 vaccine;HIV/AIDS;Immune Evasion;Immunization;Immunize;immunogenic;immunogenicity;immunoprophylaxis;improved;in vivo;Infection;insight;Knock-in;Knock-in Mouse;Knowledge;Length;Libraries;Link;Macaca;Macaca mulatta;Measures;Membrane;Messenger RNA;Modification;Molecular Conformation;Mucous Membrane;Mus;natural antibodies;neutralizing antibody;novel;particle;Peptide Hydrolases;Physiological;pre-clinical;preclinical evaluation;prevent;Prevention;Production;Property;Protomer;rational design;receptor;Recombinants;Reporting;Risk;RNA vaccine;Rodent;screening;Serum;Shapes;simian human immunodeficiency virus;single-molecule FRET;Site;Structure;Structure-Activity Relationship;Surface;Technology;Toxic effect;Transcript;Vaccinated;Vaccine Design;vaccine platform;Vaccines;Viral;Virus-like particle

PROJECT_TITLE: Structure-Function Studies of the HIV-1 Envelope Glycoproteins and Development of a VLP-forming mRNA vaccine for HIV-1


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Neurosciences;Rare Diseases

PI_NAMEs: STEELE-MORTIMER, OLIVIA  (contact)

PROJECT_TERMS: 129 Mouse;Affect;Africa South of the Sahara;Appearance;Bacteria;Bacterial Meningitis;Biological Models;Blood;Blood Vessels;blood-brain barrier crossing;blood-brain barrier penetration;Brain;C57BL/6 Mouse;Cells;Central Nervous System;Chronic;cytokine;Dendritic Cells;Development;Encephalitis;Extravasation;Genetic Determinism;Genetic Diseases;Goals;Gram-Negative Bacteria;HIV/AIDS;Human;Immune response;immunodeficiency;Infection;Inflammation;intravenous administration;Iron;Laboratory mice;Macrophage;Malaria;Malnutrition;Meninges;Meningitis;mouse model;Mus;Mutation;natural resistance-associated macrophage protein 1;neutrophil;Oral Administration;pathogenic bacteria;Persons;Play;pleiotropism;Predisposition;reconstitution;Resistance;Role;Salmonella;Salmonella enterica;Salmonella infections;Salmonella typhimurium;Sickle Cell Anemia;Systemic disease;Systemic infection;T-Lymphocyte;trait

PROJECT_TITLE: Salmonella infection in the murine brain


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Skin Cancer

PROJECT_TERMS: adaptive immunity;Anaerobic Bacteria;anti-cancer;anticancer activity;Attenuated;Bacteria;Biomedical Engineering;Cell Communication;Cells;chemotherapy;Clinical Trials;Development;Engineering;Engraftment;experience;Flow Cytometry;Future;Genes;Genetic Engineering;Goals;Human;Immune;Immune checkpoint inhibitor;Immune response;Immunohistochemistry;Immunotherapy;Infection;interest;Interleukin-2;Laboratories;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;Modeling;Mouse Strains;Mucous Membrane;Mus;mutant;Natural Immunity;Neoplasm Metastasis;neoplastic cell;Oral;Organ;Patients;plasmid DNA;prevent;Proteins;Recombinants;reconstitution;recruit;Resistance;Salmonella;Salmonella typhimurium;screening;Solid Neoplasm;success;Testing;Therapeutic;tumor;tumor growth;tumor microenvironment;Xenograft procedure

PROJECT_TITLE: Development of Salmonella for cancer therapeutics


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Eczema / Atopic Dermatitis;Food Allergies;Nutrition;Pediatric;Prevention

PI_NAMEs: FRISCHMEYER-GUERRERIO, PAMELA  (contact)

PROJECT_TERMS: accurate diagnosis;Age;Allergic;Allergic Conjunctivitis;Allergic Disease;Allergic Reaction;Allergic rhinitis;Allergy to eggs;American;Anaphylaxis;androgenic;Asthma;Atopic Dermatitis;Australia;autosome;Biological Markers;Birth;Boston;Breastfed infant;Catalogs;Child;cholest-4-en-3-one;clinical biomarkers;clinical care;clinical practice;Clinical Treatment;Clinical Trials;cohort;Collaborations;Communities;Cutaneous;Data;Defense Mechanisms;Development;Diagnosis;diagnosis standard;Diagnostic;Disease;Double-Blind Method;Eczema;effectiveness evaluation;Elements;Enrollment;Event;Exclusive Breastfeeding;Exhibits;Exposure to;Familial Platelet Disorder;Food;food allergen;food antigen;food challenge;Food Hypersensitivity;Fright;Fungal Genome;Future;General Population;Genome;Genotype;Germ Lines;high risk;Human;IgE;Immunologics;improved;infancy;Infant;insight;Life;Lipids;Mediating;Mendelian disorder;metabolomics;Metagenomics;microbial;Milk;Modality;Mothers;Myeloproliferative disease;Oral;oral tolerance;orotidine;Pathogenesis;Pathogenicity;Pathway interactions;Patient Recruitments;patient stratification;Patients;Physicians;Placebo Control;Placebos;Plasma;population based;potential biomarker;Predictive Value;Predisposition;Pregnenolone;Prevalence;Prevention trial;primary outcome;prospective;racial diversity;Randomized;Reaction;Recording of previous events;recruit;Refractory;Research Institute;Research Personnel;Risk;Risk Factors;risk stratification;RUNX1 gene;Sampling;Severities;Severity of illness;Shotguns;Skin;skin barrier;skin damage;skin microbiome;Standardization;Steroids;Swab;Testing;Tryptase;Universities;Variant;Viral;Visit;Vitamin D;Vitamin D Deficiency;Vitamin D supplementation

PROJECT_TITLE: Pathogenesis of Food Allergy


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Digestive Diseases;Food Allergies;Genetics;Immunotherapy;Pediatric;Prevention;Rare Diseases

PROJECT_TERMS: Adoptive Transfer;Affect;Allergic;Allergic Disease;Allergic inflammation;Allergic rhinitis;Antibodies;Antibody Response;Antibody titer measurement;Antigens;Asthma;Atopic Dermatitis;autosome;B Cell Proliferation;B-Lymphocytes;Biochemical;Biological Assay;BLR1 gene;Bone Marrow;CD4 Positive T Lymphocytes;Cell Physiology;Cell secretion;Cells;Chimera organism;Chronic;Colitis;comparison control;Connective Tissue Diseases;crosslink;cytokine;Defect;Development;Disease;effective therapy;engineered T cells;eosinophil;Eosinophilic Esophagitis;Epithelial Cells;Esophagus;Exhibits;experimental study;Fetal Liver;Food;food antigen;Food Hypersensitivity;FOXO1A gene;FRAP1 gene;Frequencies;Generations;Genes;Genetic;Goals;Helper-Inducer T-Lymphocyte;high risk;Human;Humoral Immunities;IgE;IgG1;Immunoglobulin Class Switching;Immunologics;Impairment;In Vitro;in vivo;inhibitor;Interleukin-13;Interleukin-4;Investigation;Link;Loeys-Dietz Syndrome;Low Prevalence;MADH4 gene;Mediating;Medical;Mendelian disorder;mesenteric lymph node;Methods;Modeling;mouse model;Mus;Mutation;Myhre syndrome;Nature;Oral;Ovalbumin;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peyer's Patches;Phase;phosphatidylinositol 3-kinase gamma;Phosphorylation;Plasmablast;Play;prevent;Production;receptor;Regulatory T-Lymphocyte;Reporting;response;Risk;Role;Sampling;Signal Transduction;Signaling Molecule;Structure of germinal center of lymph node;T-Cell Receptor;T-Lymphocyte;TGFBR1 gene;TGFBR2 gene;Transforming Growth Factor beta;Vaccines;Work

PROJECT_TITLE: The Role of Transforming Growth Factor Beta (TGFbeta) in Promoting Allergic Inflammation


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Breastfeeding, Lactation and Breast Milk;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

PI_NAMEs: MYLES, IAN  (contact)

PROJECT_TERMS: Analytical Chemistry;Antigens;Biological Assay;CD8B1 gene;Cellular Immunity;Cloning;Disease;Goals;Human;Human Milk;Hybrids;Immunotherapeutic agent;Interleukin-6;Memory;Modeling;Morphologic artifacts;Mucous Membrane;Mus;novel;Peptides;Physiology;Proteins;Reporting;response;Role;Secure;T memory cell;Transfer Factor;Tuberculosis;Work

PROJECT_TITLE: Use of Transfer Factor as a Novel Immune Therapeutic


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Liver Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: OLIVERA, ANA  (contact)

PROJECT_TERMS: Abdominal Pain;Acute;adaptive immune response;Adaptive Immune System;Affinity;Allergens;Allergic;Allergic Disease;Allergic inflammation;Allergic Reaction;Anaphylaxis;Antigens;ATR gene;Awareness;B-Lymphocytes;Bacteria;Basophils;Binding;Biological;Biological Process;biomarker identification;Blood Vessels;Body Fluids;Bone Density;Bone Diseases;Cell Communication;Cell Count;cell type;Cells;Characteristics;Chemotactic Factors;Clinical;cytokine;Diarrhea;Disease;Disease Management;draining lymph node;Etiology;Exposure to;extracellular vesicles;Family;Flushing;food allergen;food challenge;Food Hypersensitivity;Foundations;FPR1 gene;frontier;gain of function mutation;Goals;healthy volunteer;Hematopoietic;Hepatic Stellate Cell;Histamine;Human;Hypersensitivity;Hypotension;IgE;IgE Receptors;Immunity;Immunization;Immunology;immunoregulation;In Vitro;Incidence;Indolent;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;inhibitor;Innate Immune Response;Innate Immune System;insight;intercellular communication;Intercept;Intestinal permeability;Knowledge;leucyl-phenylalanine;Ligands;Link;lipid mediator;Liver;liver development;Liver Fibrosis;lymph nodes;Lymphocyte;Manuscripts;mast cell;mastocytosis;Mediating;Mediator;member;MicroRNAs;Mus;Musculoskeletal Pain;Mutation;nanosized;neoplastic;neutrophil;novel;Oncogenic;Osteoblasts;Osteoclasts;Pathogenesis;Pathology;Patients;Peptide Hydrolases;Phenotype;Plasma;Play;Process;Productivity;progenitor;programs;Proteomics;Pruritus;Publications;Publishing;Reaction;receptor;Receptor Activation;Receptor Protein-Tyrosine Kinases;Recovery;recruit;Regulation;Reporting;response;Role;Serum;Signal Pathway;Signal Transduction;Signaling Molecule;sphingosine 1-phosphate;stem cells;Stimulus;Structure;Structure of germinal center of lymph node;substantia spongiosa;Symptoms;Syncope;Systemic Mastocytosis;T-Lymphocyte;Technology;Tissues;vesicular release

PROJECT_TITLE: Identification and Characterization of Signaling Pathways and Mediators Regulating Mast Cell-Related Disorders


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

PI_NAMEs: MAYER-BARBER, KATRIN  (contact)

PROJECT_TERMS: Address;arm;Autoimmune Diseases;autoinflammatory diseases;Bacillus;bactericide;Barbering;Biological;Categories;Cell Communication;cell type;Cells;Chronic;Chronic Disease;chronic infection;Clinical;Clinical Research;clinical translation;Complex;cytokine;Cytosol;Defect;Development;Disease;Disease Progression;experimental study;Genes;Goals;granulocyte;Host resistance;Human;IL1R1 gene;Immunity;Immunologic Techniques;Immunologics;Immunology;immunoregulation;Immunotherapy;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Influenza A virus;insight;Interferon Type I;Interferons;Interleukin-1;Investigation;lipid mediator;Lung;Lung infections;Malignant Neoplasms;Mediating;Modeling;Molecular;mouse model;Mouse Strains;Mus;Mycobacterium avium;Mycobacterium tuberculosis;Mycoses;neutrophil;non-tuberculosis mycobacteria;novel;novel therapeutic intervention;Outcome;Pathogenesis;Pathology;Pathway interactions;Patients;Phagocytes;Phase;Play;predictive modeling;Predisposition;Production;programs;Property;Publishing;receptor;Research;respiratory;Respiratory Tract Infections;response;Role;Runaway;System;Therapeutic;Thinking;Tissues;translational pipeline;Tuberculosis;Vaccines;Viral;Virulence Factors;Work

PROJECT_TITLE: Innate inflammatory responses during pulmonary infections


NIH_SPENDING_CATS: Infectious Diseases

PI_NAMEs: YEWDELL, JONATHAN W (contact)

PROJECT_TERMS: Binding;Biogenesis;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Cycle;Cell Physiology;cell type;Cells;Dizziness;Endoplasmic Reticulum;Flow Cytometry;Immune;immune activation;immune function;Immunity;insight;Knowledge;Ligands;Lymphocyte;Major Histocompatibility Complex;Molecular Conformation;novel;novel marker;pathogen;peptide I;Peptides;Play;Proteins;Ribosomes;Role;Site;T-Lymphocyte;Techniques;Tissues;Translations;tumor;Viral;Virus;Virus Activation;Virus Diseases

PROJECT_TITLE: Translation in Immunity


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza

PROJECT_TERMS: Amino Acid Substitution;Antibodies;Antibody Affinity;Antibody Response;B-Lymphocytes;cost;deep sequencing;Economic Burden;Evolution;fitness;Glycoproteins;Goals;Head;Hemagglutinin;Humanities;Humoral Immunities;Immunity;Immunobiology;Immunoglobulin Class Switching;In Vitro;in vivo;Individual;Influenza;Influenza A virus;Membrane Glycoproteins;Mutation;Mutation Detection;Neuraminidase;neutralizing antibody;novel strategies;Polymerase;pressure;Process;response;seasonal influenza;Site;socioeconomics;Somatic Mutation;stem;Time;Vaccination;Viral;Viral Antigens;Virion;virology

PROJECT_TITLE: Immunobiology and Virology of Influenza A Virus


NIH_SPENDING_CATS: Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: MARTIN, MALCOLM  (contact)

PROJECT_TERMS: 2019-nCoV;Acute;Address;Adoptive Transfer;Affect;Affinity;Agonist;Animal Model;Animals;Antibodies;Antibody Therapy;antiretroviral therapy;B-Lymphocytes;Binding;Biology of HIV Infection;C-terminal;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Immunity;Chronic;Clinical;Combination immunotherapy;Complex;CRISPR/Cas technology;Development;Disease;disease model;Disease remission;emerging virus;env Gene Products;Exhibits;Fab domain;Fc domain;Future;gene-editing approach;Genes;Gorilla gorilla;HIV;HIV Infections;HIV-1;HIV/AIDS;Human;immune activation;immunodeficiency;In Vitro;in vivo Model;Infection;Interleukin-15;lymph nodes;Macaca;Macaca mulatta;Mediating;Modeling;Monkeys;Morbidity - disease rate;mouse model;Mus;Mutation;neutralizing antibody;neutralizing monoclonal antibodies;nonhuman primate;Open Reading Frames;Opportunistic Infections;Outcome;Pan Genus;Pathogenesis;peripheral blood;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Point Mutation;Prevention;Productivity;Property;Prospective Studies;protein expression;Proteins;Protocols documentation;receptor;Recombinant adeno-associated virus (rAAV);Recombinant Antibody;repaired;Reporting;Resistance;Retroviridae;Serotyping;Shapes;simian human immunodeficiency virus;SIV;Source;Splenocyte;synergism;T-Lymphocyte;Testing;Tetracyclines;Therapeutic;therapeutic protein;Variant;vector;Viral;viral rebound;Viral reservoir;Viremia;Virus

PROJECT_TITLE: The Biology of HIV Infections


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Prevention;Vaccine Related

PI_NAMEs: MARCOTRIGIANO, JOSEPH  (contact)

PROJECT_TERMS: Affect;Anti-viral Therapy;Binding;Biochemical;biophysical techniques;Biophysics;CD81 gene;Cell Line;Cells;Centers for Disease Control and Prevention (U.S.);Chronic Hepatitis C;claudin-1 protein;Complex;cost;Data;Development;Docking;Endocytosis;Endosomes;extracellular;Foundations;Genotype;Glycoproteins;Goals;Hepatitis C;Hepatitis C Vaccine;Hepatitis C virus;Hepatocyte;Individual;Infection;Infection prevention;intravenous drug use;Investments;Length;Mediating;Membrane;Membrane Fusion;Modeling;Molecular;Molecular Conformation;neutralizing antibody;occludin;Patients;Persons;Pharmacotherapy;Polyvalent Vaccine;Preparation;Process;Public Health;receptor;receptor binding;Resources;Rest;Risk Behaviors;RNA Viruses;Role;Route;Secondary to;Series;SR-BI receptor;Structure;Surface;Tight Junctions;Vaccine Design;Vaccines;Viral;Virion

PROJECT_TITLE: Entry and replication of positive-sense, RNA viruses


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human;Transmissible Spongiform Encephalopathy (TSE)

PI_NAMEs: HAIGH, CATHRYN  (contact)

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Address;Affect;Animals;Architecture;Autopsy;Back;Biomass;Bovine Spongiform Encephalopathy;Brain;brain cell;brain dysfunction;brain tissue;Catabolism;Cell Death;Cell model;Cell Physiology;Cells;Cellular biology;Cellular Stress;Cerebrum;cervid;Cessation of life;Chronic Wasting Disease;Communicable Diseases;conformer;Country;Cytoskeleton;Disease;disease-causing mutation;Effectiveness;Emerging infection;Epidermal Growth Factor Receptor;Equipment;European;Event;experimental study;Exposure to;Failure;fluorescence imaging;fluorescence microscope;Functional disorder;gamma secretase;Gene Expression;gene function;Genus Hippocampus;Growth;Homeostasis;Human;human induced pluripotent stem cells;human stem cells;imaging system;improved;in vivo;Infection;interest;International;Knock-out;Link;Malignant Neoplasms;Methods;Microscopy;Mitochondria;Modeling;Monitor;Mus;nerve stem cell;Neurons;neuroprotection;North America;Organoids;Oxidation-Reduction;oxidative damage;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Post-Translational Protein Processing;Predisposition;prevent;Prion Diseases;Prions;Process;Production;protein expression;protein function;Proteins;Proteolysis;PrP;Publishing;Pyruvate;Quality of life;Reader;recruit;Research;RNA;Role;senescence;Signal Transduction;South Korea;stem cell division;stem cell growth;stem cell model;Symptoms;System;Techniques;Testing;Therapeutic;Tissue Model

PROJECT_TITLE: Prion protein function in redox homeostasis and associated failure in prion disease


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Pediatric;Prevention;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: GOLDBACH-MANSKY, RAPHAELA  (contact)

PROJECT_TERMS: Adhesions;Adrenal Cortex Hormones;Adult;American;Amyloidosis;anakinra;Animal Model;antagonist;Arthralgia;Arthritis;autoinflammatory;autoinflammatory diseases;Biological Markers;biomarker validation;Blocking Antibodies;Blood Vessels;bone;CDC42 gene;Cell Culture System;Cell Differentiation process;Cell Line;Cell Physiology;Central Nervous System;Childhood;Chronic;Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature;Clinic;Clinical;clinical phenotype;cohort;Collaborations;college;Combined Modality Therapy;Complex;COVID-19 patient;cytokine;Cytokine Signaling;Dasatinib;Data;de novo mutation;design;Development;Diagnosis;disability;Disease;disorder control;Dose;Drops;Drug Modelings;drug testing;DYSF gene;early onset;Early treatment;Endothelial Cells;Endothelium;European;Evaluation;Exanthema;Expert Opinion;Eye;Fatty acid glycerol esters;Fever;Fibrosis;Flare;follow-up;Follow-Up Studies;gain of function mutation;Genes;Genetic;genetic signature;Goals;Hemophagocytic Lymphohistiocytoses;Heterozygote;human induced pluripotent stem cells;human model;Iatrogenesis;IFNAR1 gene;IL18 gene;IL1R1 gene;Immune;improved;In Vitro;induced pluripotent stem cell;infancy;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Bowel Diseases;inhibitor;Injections;Integrins;Intercellular adhesion molecule 1;Interferon Type II;Interferons;Interleukin-1;Interleukin-1 beta;Interleukin-1 Receptors;Interstitial Lung Diseases;Intervention;Kidney;kidney amyloidosis;kinase inhibitor;Laboratories;Labyrinth;Life;Liver Fibrosis;Longterm Follow-up;Lung Diseases;LYN gene;Macrophage;Macrophage activation syndrome;Mass Spectrum Analysis;Measures;Mediating;Medical;Mendelian disorder;migration;Modeling;Molecular;Monitor;monocyte;mortality;multicatalytic endopeptidase complex;Muscle;Mutation;Myeloid Cells;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;Natural History;Neonatal Onset Multisystem Inflammatory Disease;Nephrotic Syndrome;neutrophil;novel;Organ;Organ Model;Outcome;participant enrollment;Pathogenesis;Pathogenicity;Patient Selection;patient subsets;Patients;pediatric patients;peripheral blood;Pharmaceutical Preparations;Phosphotransferases;Pilot Projects;Polyglandular Autoimmune Syndrome Type I;prevent;Prevention strategy;Process;Production;programs;Protocols documentation;Publishing;Pulmonary Alveolar Proteinosis;Rare Diseases;receptor;Recombinant Proteins;Recombinants;Reporting;Resolution;response;Rheumatology;Rhubarb food;Risk;RNA Splicing;Role;Safety;Sampling;Secondary to;Serum;side effect;Signal Transduction;Site;Skin;small molecule;Source;src-Family Kinases;stem cells;STING-associated vasculopathy;Syndrome;systemic inflammatory response;targeted treatment;Tissues;tool;transcriptomics;Treatment Efficacy;Treatment Protocols;Undifferentiated;Validation;Variant;Vascular Diseases;Vasculitis;Viral;Visit

PROJECT_TITLE: Pathogenesis, and Outcome of Autoinflammatory Diseases, NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still's-like Diseases, and other Undifferentiated Autoinflammatory Diseases


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Hematology;Immunotherapy;Infectious Diseases;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

PI_NAMEs: NOTARANGELO, LUIGI  (contact)

PROJECT_TERMS: Accounting;Affect;Animal Model;Antibodies;Antibody-drug conjugates;Autoimmune;Autoimmune Diseases;Autoimmune hemolytic anemia;autoinflammatory diseases;Automobile Driving;B cell differentiation;B-Cell Antigen Receptor;base;Biological Assay;Biological Markers;Bone Marrow Purging;California;Candidiasis;Cells;Cephalic;Cervical;Chronic Granulomatous Disease;Clinical;Collaborations;Complex;congenital immunodeficiency;Cutaneous;Data;Defect;Development;differentiation in vitro;Disease;DNA Polymerase III;Engraftment;Evaluation;Facies;FLT3 ligand;France;gene therapy;Generations;Genes;Genetic Diseases;genetic variant;genotyped patients;Goals;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Heterogeneity;Human;human model;humanized mouse;Immune;immune reconstitution;Immune system;Immune Tolerance;immunopathology;Immunotoxins;Impairment;In Vitro;in vivo;Individual;Infection;Inflammatory;insight;Interferon Type I;Interferon Type II;Investigation;Knowledge;Laboratories;Life;loss of function;Loss of Heterozygosity;Lymphopenia;member;Molecular;molecular pathology;Monoclonal Antibodies;mouse model;Mucous Membrane;Multicenter Studies;Mus;Mutate;Mutation;Natural History;Nature;neutrophil;NFKB Signaling Pathway;novel;novel therapeutic intervention;Omenn syndrome;Outcome;Oxidases;Paris, France;pathogen;patient derived induced pluripotent stem cells;Patients;Phenotype;Platelet Count measurement;Polyglandular Autoimmune Syndrome Type I;pre-clinical;pre-T cell receptor alpha;Predisposition;prevent;Production;PTPRC gene;reconstitution;Reporting;Research Project Grants;Review Literature;Risk;Role;San Francisco;Series;Severe Combined Immunodeficiency;skin microbiome;Structure;Structure of thymic medulla;Surface;Syndrome;T-Cell Receptor;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Thymus Gland;Tissues;TNFRSF5 gene;tool;Transplantation;United States National Institutes of Health;Universities;Variant;Virus Diseases;Visceral Leishmaniasis;Wiskott-Aldrich Syndrome

PROJECT_TITLE: Characterization of the cellular and molecular bases of inborn errors of immunity


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cervical Cancer;Genetics;Human Genome;Infectious Diseases;Orphan Drug;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

PI_NAMEs: MCBRIDE, ALISON  (contact)

PROJECT_TERMS: cancer cell;Cancer Cell Growth;Cell Death;Cells;Cervical;chromosome conformation capture;design;Development;Genetic;Genetic Transcription;Genome;Goals;Growth;Human;Human Genome;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;insight;Malignant neoplasm of cervix uteri;malignant oropharynx neoplasm;Oncogenes;Oncogenic;Play;Process;Role;targeted treatment;Techniques;Therapeutic Intervention;tumorigenesis;Viral;Viral Oncogene;Virus Integration

PROJECT_TITLE: The Role and Mechanism of Integration in Oncogenic Progression of HPV associated cancers


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: DUFFY, PATRICK  (contact)

PROJECT_TERMS: Acceleration;Adjuvant;Adult;Africa;African;Agreement;Anopheles Genus;Antibodies;Antibody Response;Antibody titer measurement;Antigens;Area;arm;Biological Assay;Blocking Antibodies;Blood;Blood Group Antigens;Brazil;burden of illness;Cambodia;cell bank;Cells;cGMP production;chemical conjugate;chemokine receptor;Chimeric Proteins;circumsporozoite protein;Clinical;clinical center;clinical development;Clinical Research;Clinical Trials;Conjugate Vaccines;COVID-19;Culicidae;Cyclic GMP;density;Development;Disease;Documentation;Dose;efficacy study;Erythrocytes;Erythroid;Escherichia coli;Ethics;experience;feeding;field study;first-in-human;Formulation;Funding;Generations;genetic variant;Germ Cells;Goals;healthy volunteer;Hepatitis B Virus;Human;human study;immunogenic;immunogenicity;Individual;Infection;Interruption;Invaded;Investigational New Drug Application;Length;Malaria;malaria transmission;Malaria Vaccines;man;manufacture;Membrane;Microbe;model development;Modeling;Monkeys;monomer;Mus;mutant;nanoparticle;National Institute of Allergy and Infectious Disease;Oryctolagus cuniculus;Parasites;Participant;Patients;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;phase II trial;Plasmodium falciparum;Plasmodium vivax;Plasmodium vivax vaccine;Population;preclinical development;preclinical evaluation;Preparation;Process;product development;Production;Progress Reports;Proteins;Protocols documentation;Pseudomonas aeruginosa;Publications;Published Comment;receptor;Recombinant Proteins;Recombinants;Reporting;Safety;Saimiri;Saponins;Series;Serum;Site;Skin;Specific qualifier value;Sporozoites;Surface;Testing;timeline;Toxicology;Toxin;transmission blocking;transmission process;transmission-blocking vaccine;United States National Institutes of Health;Universities;Vaccinated;vaccine candidate;vaccine development;Vaccines;Validation;validation studies;Vial device;Virus-like particle;Vivax Malaria;volunteer

PROJECT_TITLE: Malaria Vaccines:  Pvs230D1-EPA and PvCSP


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;Zika Virus

PI_NAMEs: HICKMAN, HEATHER  (contact)

PROJECT_TERMS: adaptive immune response;Anatomy;antiviral immunity;cell type;Cells;Chikungunya virus;Color;Complex;Confocal Microscopy;DNA Viruses;draining lymph node;Effector Cell;experimental study;Fluorescence;Generations;Goals;Image;imaging modality;Immune;Immune response;Immunity;Immunologics;in vivo;Infection;interest;intravital imaging;Location;lymph nodes;Mediating;Memory;Modeling;multiphoton microscopy;Mus;nonhuman primate;Pathogenesis;pathogenic virus;Peripheral;prevent;Process;response;RNA Viruses;secondary lymphoid organ;Shapes;Simplexvirus;Site;SIV;Small RNA;Techniques;Time;Tissues;Viral;Virus;Visualization;Zika Virus;ZIKV infection

PROJECT_TITLE: Imaging Antiviral Immunity


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

PROJECT_TERMS: Alleles;Anti-malarial drug resistance;Biological;Blood;Chemicals;Child;Chloroquine resistance;Codon Nucleotides;cohort;cost effective;Deoxyribonucleases;Diagnostic;Dideoxy Chain Termination DNA Sequencing;DNA;Drug Monitoring;Drug resistance;drug-sensitive;Dryness;epidemiology study;Ethanol;Filariasis;Frequencies;Genes;Genotype;Guinea;Health;improved;Infection;Liberia;Malaria;Mali;Measures;Merozoite Surface Protein 1;Methods;Molecular Epidemiology;molecular marker;Monitor;Mutation;Organism;Paper;Parasitemia;Parasitic infection;Performance;Plasmodium;Plasmodium falciparum;population based;Pregnant Women;Prevalence;prevent;Progress Reports;Protocols documentation;Public Health;Publications;research study;Resistance;resistance allele;resistance gene;resistant Plasmodium falciparum;Sampling;Schistosoma;Science;Seasons;Spottings;Strongyloides stercoralis;surveillance study;Surveys;Techniques;Testing;Variant;Water

PROJECT_TITLE: Malaria Surveillance and Research Studies in Liberia and Guinea-Conakry


NIH_SPENDING_CATS: Genetics;Rare Diseases

PI_NAMEs: KRISTIE, THOMAS M (contact)

PROJECT_TERMS: Biochemical;Cells;clinical phenotype;Cobalamin;Data Set;Development;Disease;Enzymes;Epilepsy;Fibroblasts;Genetic Transcription;Genome;Homocystinuria;host cell factor C1;Intellectual functioning disability;Link;Metabolism;methylmalonic aciduria;Molecular;mouse model;Mutation;Neurologic;Pathway interactions;Patients;Phenotype;Proteins;recruit;Syndrome;Tissues;Transcription Coactivator;Vitamin B 12

PROJECT_TITLE: Molecular basis of cblX syndrome


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Digestive Diseases;Infectious Diseases;Neurosciences;Rare Diseases

PI_NAMEs: NUTMAN, THOMAS  (contact)

PROJECT_TERMS: Adrenal Cortex Hormones;Adult;Affect;Antibodies;Antigens;Archives;Area;Autoantibodies;biobank;Biological Assay;Biological Markers;Blood;Brain;Case Series;CD4 Positive T Lymphocytes;Cell Line;Cells;Central Nervous System;Cestoda;chemokine;Clinical;Clinical Data;Clinical Laboratory Improvement Amendments;Clinical Protocols;clinical research site;cohort;Collaborations;Country;Cross Reactions;Cyst;cytokine;Data;Detection;Development;Diagnosis;diagnostic assay;Disease;Disease Outcome;Epilepsy;experience;follow-up;Genus Tenia;Helminths;Historical Cohort Studies;Human;Human Subject Research;Image;improved;indexing;Infection;Inflammation;Inflammatory;Interleukin-10;Intervention;Longterm Follow-up;Manuscripts;Mediating;Morbidity - disease rate;mortality;Natural History;Nature;neglect;Nervous System Disorder;Neurocysticercosis;neuroimmunology;neuroinflammation;Neurology;neurotoxic;Organism;Outcome;Parasites;Pathogenesis;Pathology;Patients;Persons;Phenotype;Population;Process;Productivity;Proteins;Publications;Publishing;Reaction;Recruitment Activity;Regulatory T-Lymphocyte;Relapse;Reporting;research study;Retrospective Studies;Risk;Role;Sampling;Seizures;self-renewal;Series;Source;Spinal Cord;standard care;stem cells;Subarachnoid Space;Sylvius fissure;Taenia solium;Teniasis;Testing;Time;treatment planning;treatment response;Ventricular

PROJECT_TITLE: Biomarkers and host-parasite interactions in neurocysticercosis and other helminths


NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: TOLIA, NIRAJ  (contact)

PROJECT_TERMS: acquired immunity;Adult;Antibodies;Antibody Response;Antibody-mediated protection;Antigen Targeting;Antigenic Variation;Antigens;apical membrane;B-Lymphocytes;Binding;Binding Sites;Biology;Cells;Cessation of life;Clinical;Collaborations;Communication;Complex;Culicidae;Data;design;Development;Disease;Disease Progression;Engineering;Epitopes;Exhibits;Florida;Goals;Human;Immune response;Immune system;Immunity;Immunize;improved;in vivo;Infection;insight;Intervention;Invaded;Knowledge;Life Cycle Stages;Liver;liver infection;Malaria;malaria transmission-blocking vaccine;Malaria Vaccines;manufacture;Maps;Mediating;Membrane Proteins;Modality;Monoclonal Antibodies;Mus;Nature;Neck;neutralizing antibody;next generation;novel;Parasites;Parasitic infection;pathogen;Pathogenesis;Plasmodium falciparum;Plasmodium vivax;prevent;Protein Family;Proteins;Publishing;Reporting;Research;response;rhoptry;Sterility;Structure;T-Lymphocyte;Technology;Therapeutic Intervention;Transcend;Transgenic Organisms;transmission process;Universities;Vaccine Antigen;vaccine candidate;Vaccine Design;vaccine development;vaccine immunogenicity;Vivax Malaria;Work

PROJECT_TITLE: Mechanisms of effective antibody neutralization


NIH_SPENDING_CATS: Immunization;Infectious Diseases;Malaria;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PROJECT_TERMS: Antigen Receptors;Avidity;Binding;Binding Sites;Biology;Blood;Blood Group Antigens;CD44 gene;Cell surface;Cell Surface Proteins;Cells;chemokine receptor;Collaborations;Complex;Culicidae;Cytoskeleton;Diagnostic;editorial;Erythrocytes;Erythroid;experimental study;Glycophorin C;Goals;GYPA gene;Human;Immunoglobulin Constant Region;Individual;Infection;insight;Intervention;Invaded;Knowledge;Life Cycle Stages;Ligands;Malaria;malaria transmission;Microbe;Modality;Modeling;Molecular;monomer;novel vaccines;parasite invasion;Parasites;Parasitology;pathogen;Pathogenesis;Phenotype;Plasmodium falciparum;Plasmodium vivax;Polysaccharides;prevent;protein complex;protein structure;Proteins;Publishing;rational design;receptor;receptor binding;Reporting;Resistance;Reticulocytes;Role;Source;Structure;Surface;Testing;Therapeutic;therapy development;Tight Junctions;trend;Universities;vaccine candidate;Vaccine Design;vaccinology;vector;vector mosquito;vector transmission

PROJECT_TITLE: Structural characterization of host-pathogen interactions


NIH_SPENDING_CATS: Asthma;Biotechnology;Genetics;Human Genome;Immunization;Immunotherapy;Infectious Diseases;Lung;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: SCHWARTZBERG, PAMELA  (contact)

PROJECT_TERMS: adaptive immunity;Adhesions;Adhesives;Affect;Affinity;Antibodies;Antibody Formation;Antibody-mediated protection;Area;Asthma;Autoantibodies;Autoimmunity;B-Lymphocytes;Biochemical;cancer therapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Adhesion;Cell Communication;Cell Differentiation process;cell growth;Cell Physiology;Cells;Cellular biology;chronic infection;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complement;congenital immunodeficiency;Coupled;CRISPR library;CRISPR screen;cytokine;Cytokine Signaling;cytotoxic CD8 T cells;Defect;Development;Disease;Effector Cell;Eosinophilic Esophagitis;Epigenetic Process;Epstein-Barr Virus Infections;exhaust;exhaustion;Extrinsic asthma;Feedback;FRAP1 gene;frontier;Functional disorder;gene function;Gene Targeting;Generations;Genes;Genetic;genetic approach;Genetic Diseases;Genetic Transcription;Genomics;Goals;Growth;GTPase-Activating Proteins;Guanosine Triphosphate Phosphohydrolases;Health;Helper-Inducer T-Lymphocyte;HIV/HCV;Homeostasis;Human;Human Herpesvirus 4;human model;Humoral Immunities;Hypersensitivity;Immune;immune checkpoint blockade;immune function;Immune response;Immunity;Immunization;immunodeficiency;Immunoglobulin Class Switching;immunopathology;In Vitro;in vivo;Infection;Infectious Agent;Inflammatory Response;insight;interdisciplinary approach;interest;Interferon Type II;Interleukin-2;Interleukin-9;Link;Lymphocyte;Lymphocyte Function;Lymphoma;Malignant Neoplasms;Mediating;Memory;Metabolic;Methods;Modeling;mouse model;Mus;Mutagenesis;Mutation;National Institute of Allergy and Infectious Disease;Nature;Paper;Pathology;Pathway interactions;Patients;Pattern;Phenotype;Phosphatidylinositols;Phosphorylation;Phosphotransferases;Play;Population;Preparation;prevent;Production;progenitor;Protein Biochemistry;Protein Tyrosine Kinase;Pulmonary Pathology;Pyroglyphidae;Qi;Regulation;Reporting;Repression;resident commensals;response;Role;sharpin;Signal Pathway;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;stem;stem-like cell;Steroid-resistant asthma;Structure of germinal center of lymph node;Syndrome;T cell response;T-Lymphocyte;TCF Transcription Factor;Technology;Th2 Cells;tool;trafficking;transcription factor;trend;tumor;Viral;whole genome;Work

PROJECT_TITLE: Genetic and Biochemical Approaches to Tyrosine Kinase and Lymphocyte Signaling


NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lupus;Pneumonia and Influenza;Prevention;Vaccine Related

PROJECT_TERMS: Adjuvant;Affect;Autoimmune Diseases;Biological;Biological Assay;Blood;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chronic Disease;Communicable Diseases;Complement;Data;Databases;design;Development;Diabetes Mellitus;Disease;Equine mule;Evaluation;follow-up;Follow-Up Studies;Functional disorder;Generations;Heart Diseases;high dimensionality;Human;Immune;Immune response;Immune system;Immune System Diseases;Immunity;Immunization;Immunology;improved;Individual;Inflammation;Influenza A Virus, H5N1 Subtype;Influenza vaccination;influenza virus vaccine;Laboratories;Lupus;Malignant Neoplasms;Modeling;Molecular;Nerve Degeneration;New York;novel vaccines;Obesity;Paper;Pathogenesis;Prevention;Productivity;Proteomics;response;sample collection;Serum;Severe Acute Respiratory Syndrome;Severities;Systems Biology;Technology;Therapeutic;Time;United States National Institutes of Health;Vaccination;vaccine efficacy;vaccine immunogenicity;vaccine response;vaccine trial;Vaccines;Variant;Work

PROJECT_TITLE: Immune Responses to Influenza Vaccination


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Autoimmune Disease;Brain Disorders;Clinical Research;Dementia;Disability Research;Frontotemporal Dementia (FTD);Immunotherapy;Infectious Diseases;Multiple Sclerosis;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: BIELEKOVA, BIBIANA  (contact)

PROJECT_TERMS: Acceleration;Accelerometer;Age;Aging;Algorithms;Annexins;Atrophic;Autoimmune;autoinflammatory;axon injury;B cell clonality;B-Cell Antigen Receptor;Binding;Biological Markers;Brain;Categories;Cells;Cellular Phone;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;central nervous system injury;Cerebrospinal Fluid;Cervical spinal cord structure;Clinical;Clinical/Radiologic;clinically relevant;cohort;comparison control;corticobasal degeneration;COVID-19 pandemic;Cytomegalovirus;Data;Databases;Development;Diagnosis;Diagnostic;digital;Digital biomarker;disability;Disability scale;Disease;Early treatment;effective therapy;Elderly;Epitopes;Epstein-Barr Virus latency;Exons;Family;Flow Cytometry;foot;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Gait;Genes;glial activation;Healthcare;Human;Human Herpesvirus 4;Image;Immune;Immune response;Immune system;Immunoassay;immunomodulatory therapies;immunoregulation;Inflammatory;Influenza;Interferon Type I;Knowledge;Learning;Length;Libraries;Lower Extremity;Lysosomes;Lytic Virus;Machine Learning;Magnetic Resonance Imaging;Measures;Mediating;Messenger RNA;Modification;molecular marker;Movement;multimodality;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Muscle;Nerve Degeneration;Nervous System Disorder;Nervous System Physiology;Nervous System Trauma;Neurofilament-L;Neuroimmune;neuroimmunologic disease;Neurologic Deficit;Neurologic Dysfunctions;Neurologic Examination;Neurologist;Neurology;neuroprotection;novel;optimal treatments;Outcome;Paper;Patients;Persons;phase II trial;Physicians;Physiological;Population;Posture;predictive marker;prevent;Process;Prognostic Marker;Property;protein TDP-43;Proteins;Protocols documentation;Psychometrics;Publishing;Rare Diseases;Relapsing-Remitting Multiple Sclerosis;Reporting;Research;Research Personnel;response;rho;RNA;Role;Sampling;screening;Self Administration;Sensitivity and Specificity;Signal Transduction;Specialist;Spinal Cord;Spinal Cord Lesions;Syndrome;T cell clonality;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Telemedicine;Testing;Therapeutic Agents;Time;tissue repair;Toes;tool;Transcript;transcriptomics;United States Food and Drug Administration;Validation;Variant;Viral;Viral Proteins;Walking;Writing

PROJECT_TITLE: Comprehensive multimodal analysis of patients with neuroimmunological diseases


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Human Fetal Tissue;Multiple Sclerosis;Neurodegenerative;Neurosciences;Patient Safety

PROJECT_TERMS: Acute;Age;arm;Axon;Benefits and Risks;Biological Markers;Biological Process;Blinded;Blood - brain barrier anatomy;Blood Cells;Cardiovascular Diseases;Caring;Central Nervous System;Cessation of life;Characteristics;Chronic;clinical practice;Clinical Trials;Combined Modality Therapy;comorbidity;Complex;Data;Demyelinations;disability;Disability outcome;Disease;Disease remission;Drug Combinations;drug development;drug efficacy;Drug Targeting;drug testing;effective therapy;Endothelium;Enhancing Lesion;Etiology;Exclusion;exhaust;FDA approved;Functional disorder;glucose metabolism;hazard;Heart;Hypertension;illness length;Immune;immunoregulation;Individual;individual patient;Infection;Inflammation;Injury;Knowledge;knowledge base;Lesion;Lifelong disability;lipid disorder;lipid metabolism;Magnetic Resonance Imaging;Measurable;Measurement;Measures;Meta-Analysis;Methodology;Modeling;Molecular;Morbidity - disease rate;mortality;mortality risk;Multiple Sclerosis Lesions;multiple sclerosis patient;multiple sclerosis treatment;Nervous System Trauma;Neurological disability;neuron loss;Neurons;novel;Online Systems;Paper;Pathogenicity;Pathology;patient population;Patient Recruitments;Patients;Pharmaceutical Preparations;Pharmacodynamics;Phase;Phase II Clinical Trials;Placebos;precision medicine;Prevalence;Printing;Process;prospective;Protocols documentation;Publishing;Randomized;Relapse;repaired;Residual state;Risk;risk/benefit ratio;Sample Size;screening;Severity of illness;successful intervention;System;Testing;Therapeutic;Therapeutic Agents;Thrombophilia;Tight Junctions;Time;treatment duration;Treatment Efficacy;treatment risk;Validation

PROJECT_TITLE: From therapeutic mechanisms to unraveling the pathophysiology of MS


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases;Zika Virus

PI_NAMEs: CALVO, ERIC  (contact)

PROJECT_TERMS: Aedes;Affect;Alpha-glucosidase;Anopheles gambiae;Anti-Inflammatory Agents;Arboviruses;Arthropods;Binding;Biochemical;Biogenic Amines;Biological;Biological Assay;Biology;Bite;Blood;Blood Proteins;Calcium ion;Comprehension;cost;CRISPR/Cas technology;Culex (Genus);Culicidae;Dengue Infection;Dengue Virus;Development;Digestion;disease transmission;Docking;drug development;Eicosanoids;Engineering;Entomology;Enzymes;Exhibits;feeding;fitness;Flavivirus Infections;gene drive system;gene editing technology;Gene Expression;gene product;Genes;Hemostatic function;Human;Immune;Immune response;Immune signaling;Impairment;In Vitro;in vivo;Infection;Inflammasome;Ingestion;insight;Invaded;Knock-out;Laboratories;Leukotrienes;loss of function;Malaria;malaria transmission;male;Mediating;Medical;Midgut;Modeling;Molecular;Monosaccharides;mutant;Natural Immunity;novel;Orthologous Gene;Parasites;Parasitic infection;pathogen;Pathogenesis;Pathway interactions;Plasmodium;Plasmodium falciparum;Plasmodium gallinaceum;Play;Polysaccharides;preference;prevent;Process;Property;Proteins;receptor;Research;Resolution;Rodent;Role;Saliva;saliva secretion;Salivary;salivary gene;Salivary Glands;Salivary Proteins;sex;Signaling Molecule;Site;Skin;Specificity;Structural Models;Structure;Sucrose;sugar;Tissues;transmission process;vector;vector mosquito;Vector-transmitted infectious disease;Viral;Viral Physiology;Virus;Virus Diseases;Work;Yellow Fever;Zika Virus;ZIKV infection

PROJECT_TITLE: Arthropod saliva in vector-borne disease transmission: Functional analysis of novel domains in salivary secretions


NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Cerebrovascular;Clinical Research;Coronaviruses;Digestive Diseases;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Lung;Microbiome;Pediatric;Prevention;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: FREEMAN, ALEXANDRA  (contact)

PROJECT_TERMS: Air;airway epithelium;Aneurysm;angiogenesis;anti-microbial peptide;Aorta;Area;Arteries;artery stenosis;Arthritis;Atherosclerosis;Autoimmune;Autoimmunity;Award;bench to bedside;biomedical referral center;Blood Vessels;Bone Marrow Transplantation;bronchial epithelium;Bronchiectasis;Bronchoscopy;calcification;Candida;cerebral artery;Clinic;Clinical;clinical care;clinical phenotype;Clinical Protocols;Clinical Research;cohort;Collaborations;Collection;Complex;congenital immunodeficiency;Connective Tissue;Coronary artery;COVID-19;COVID-19 pandemic;COVID-19 vaccine;cytopenia;Data;Defect;Dental;Dermatology;Diagnosis;Diffuse;Disease;DOCK8 deficiency;Dominant-Negative Mutation;Early Diagnosis;Eczema;Education;Epithelial Cells;Etiology;experience;Funding;Gastrointestinal Hemorrhage;Genetic Predisposition to Disease;Genus staphylococcus;Goals;Grant;Hematopoietic Stem Cell Transplantation;Hemorrhage;HIF1A gene;HIV Seronegativity;Host Defense;Human Papillomavirus;Hyper-IgE Syndrome;Hypersensitivity;IgE;IL2RG gene;Image;Immune;Immune response;immunodeficiency;Immunologics;improved;In Vitro;Incidence;Individual;Infection;insight;interest;Interferons;interleukin-12 receptor;Kaposi Sarcoma;Laboratories;Laboratory Research;Laboratory Study;Liver diseases;Longterm Follow-up;Lung;Lung Diseases;Lung infections;Lupus;lupus-like;Malignant Neoplasms;Manuscripts;Matrix Metalloproteinases;Mendelian disorder;microbial;microbiome;Morbidity - disease rate;mortality;Mucins;Mutation;Myocardial Infarction;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;neutrophil;novel;Occupations;Omenn syndrome;Operative Surgical Procedures;Osteoporosis;Paper;pathogen;Pathogenesis;Pathologic;Pathway interactions;patient oriented;patient population;Patient Selection;Patients;Phenotype;Population;Predisposition;Prospective Studies;Protocols documentation;Publishing;recurrent infection;Research;research study;response;Risk Factors;Safety;scoliosis;Signal Transduction;Site;skeletal abnormality;skin biopsy;skin disorder;skin microbiome;Spain;Sputum;STAT1 gene;STAT3 gene;Subarachnoid Hemorrhage;Syndrome;System;Thinness;Tissues;Training;transplant centers;Transplantation;United States National Institutes of Health;Vaccines;vascular abnormality;Vascular Diseases;Vasculitis;viral DNA;Viral Load result;Virus;wound healing

PROJECT_TITLE: Primary Immune Deficiency Clinic


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases

PI_NAMEs: DEKKER, JOHN  (contact)

PROJECT_TERMS: Acute;Alleles;Animals;Antibiotic Resistance;antibiotic resistant infections;Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;Area;attributable mortality;auxotrophy;Bacteremia;Bacterial Genome;Bacteroides fragilis;Biology;Bordetella;Burkholderia;Carbapenems;Ceftazidime;Cell Line;Chickens;Chromosome Deletion;chromosome fusion;Chromosomes;chronic infection;Citric Acid Cycle;Clinical;clinical center;Collaborations;Collection;Communication;Complex;Cryoelectron Microscopy;Development;digital;DNA;DNA Insertion Elements;DNA Polymerase III;DNA Replication Proofreading;DNA Restriction-Modification Enzymes;Down-Regulation;efflux pump;Electron Microscopy;emerging pathogen;Engineering;Environment;Enzymes;Event;Evolution;experimental study;Fluorescence;gastrointestinal;Gene Expression;Generations;Genes;Genetic Drift;Genetic Transcription;Genome;genome sequencing;Genomic approach;Genomics;Gluconeogenesis;Goals;homologous recombination;Host Defense;Human;IL12RB1 gene;Image;Immune Evasion;Immunocompromised Host;in vivo;Individual;Infection;infectious disease treatment;Insertional Mutagenesis;Interruption;Investigation;Measurement;Mediating;Mediator;Meropenem;Metabolic;Metabolism;metabolomics;Methylation;methylome;Methyltransferase;Mismatch Repair Deficiency;Modeling;Modern Medicine;Modification;Motility;Multi-Drug Resistance;Mutation;nanopore;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;novel;Ontology;Operon;Organism;Parents;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Patients;Phenotype;Phenylalanine;Physiology;Population Dynamics;Positioning Attribute;Predisposition;promoter;Proteins;Pseudomonas aeruginosa;Publishing;Reporter;Resistance;resistance gene;resistance mechanism;resistance mutation;Reverse Transcriptase Polymerase Chain Reaction;Role;single molecule;Structure;System;Systems Biology;Tazobactam;Testing;transcriptome;transcriptomics;United States National Institutes of Health;vector;whole genome;Work;Zoonoses

PROJECT_TITLE: Application of Genomic Approaches to Bacterial Pathogenesis and Mechanisms of Antimicrobial Resistance


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: VEGA-RODRIGUEZ, JOEL  (contact)

PROJECT_TERMS: Actomyosin;Adjuvant;Affect;Alteplase;Anopheles Genus;Anti-malarials;Antibodies;Apyrase;Area;Bacteria;Binding;Biological Assay;Biology;Bite;Blood;Blood Vessels;Bolus Infusion;Cell Surface Receptors;Cells;Communication;comparison control;Complement;complement system;Complex;Complex Mixtures;Culicidae;Data;Deposition;Development;disease transmission;enolase;Enzyme Precursors;Enzyme-Linked Immunosorbent Assay;Enzymes;Extracellular Matrix;Extracellular Matrix Proteins;feeding;Fertilization;Fibrin;Fibrin fragment D;Fibrinolysis;fungus;Gene Expression;Germ Cells;Goals;Hemolymph;Hemostatic Agents;Hemostatic function;Human;Immune response;Immunize;Immunohistochemistry;Impairment;In Vitro;Individual;Infection;Ingestion;Innate Immune Response;Innate Immune System;Integration Host Factors;Interruption;Intervention;Invaded;Kringles;Laboratories;Life Cycle Stages;Liver;Malaria;malaria transmission;Mammals;Measures;Mediating;microorganism;Midgut;migration;Molecular;Molecular Target;Mosquito Control;Mosquito-borne infectious disease;Motility;Motor;Mus;Nature;Oocysts;Outcome;P-Selectin;Parasites;Parasitic infection;pathogen;Pathogenicity;Pattern;Peptide Hydrolases;Plasmin;Plasminogen;Plasminogen Activator;Plasminogen Activator Inhibitor 1;plasminogen receptor;Plasmodium;Plasmodium falciparum;Platelet Activation;Platelet aggregation;Play;Prevalence;Property;Proteins;receptor;Recombinant Proteins;recruit;Reporting;Research;Role;Saliva;Salivary;Salivary Proteins;Science;Serine Protease;Sexual Development;Sexual Reproduction;Site;Skin;small molecule;Sporozoites;Stains;Supplementation;Surface;System;Testing;Tissues;Transcript;transcriptome;Transgenic Organisms;transmission blocking;transmission process;Urokinase;Vaccines;vector;vector mosquito;Virulence;Viscosity;Work;zygote

PROJECT_TITLE: Host-parasite-vector interactions during malaria transmission


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PROJECT_TERMS: acquired immunity;Antibodies;Antibody Response;Antigen Presentation;Antigenic Variation;Antigens;B-Lymphocytes;Binding Proteins;Biology;Blocking Antibodies;Blood;chemical conjugate;Clinical;clinically relevant;Communicable Diseases;Communication;Complex;computer cluster;Cryoelectron Microscopy;Culicidae;Data;design;Development;Epitopes;Erythrocytes;Ferritin;Foundations;Genetic;high end computer;Human;Immune;Immune response;Immunity;immunogenic;immunogenicity;improved;In Vitro;Infection;Length;Life Cycle Stages;Malaria;Malaria Vaccines;manufacture;Methods;Molecular Conformation;Names;nanoparticle;National Institute of Allergy and Infectious Disease;Nature;neutralizing antibody;novel;novel vaccines;Parasites;pathogen;placental malaria;Plasmodium;Plasmodium vivax;prevent;Procedures;Production;protein complex;Protein Conformation;Protein Engineering;Proteins;Publishing;receptor;receptor binding;Recombinant Proteins;Reporting;response;scaffold;Science;screening;self assembly;Serum;Sterility;Structure;Surface Antigens;Symptoms;System;T-Lymphocyte;Technology;thermostability;three dimensional structure;Transcend;transmission process;transmission-blocking vaccine;Vaccination;Vaccine Antigen;vaccine candidate;vaccine development;vaccine efficacy;vaccine platform;Vaccine Production;vaccine strategy;vaccine trial;Vaccines;vaccinology;Work;X-Ray Crystallography

PROJECT_TITLE: Structural vaccinology for infectious diseases