NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Prevention;Stroke

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE Stroke is the second leading cause of death and a leading cause of major disability globally, and is becoming more frequent with the aging population. NIH StrokeNet is a network of clinical sites and experts across the country working together to develop and complete multi-site clinical trials, the final step in proving that new potential treatments will work, and to train the next generation of clinical researchers. The National Coordinating Center leads and manages this network to test new ways to treat, prevent, and aid in recovery and rehabilitation from stroke.

PI_NAMEs: BRODERICK, JOSEPH PAUL (contact);KHATRI, POOJA

PROGRAM_OFFICER_NAME: FARACO, CARLOS CESAR

PROJECT_TERMS: Age;aging population;Ancillary Study;biomarker validation;career development;Cause of Death;Cerebrovascular Disorders;Clinical;Clinical Research;clinical research site;Communities;Contracts;Country;design;disability;Education;Elderly;experience;Funding;Image;Incidence;innovation;International;Leadership;Methodology;Multi-Institutional Clinical Trial;multi-site trial;National Institute of Neurological Disorders and Stroke;next generation;Participant;Pharmacy facility;Population;prevent;Prevention;Recovery;recruit;Research;Research Personnel;Site;Stroke;stroke rehabilitation;Testing;Training;trial design;United States National Institutes of Health;Universities;validation studies;Work

PROJECT_TITLE: NIH StrokeNet National Clinical Coordinating Center


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: East Greenwich

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Summary Cell polarity is of fundamental importance to all of biology and to human health and is perturbed in numerous developmental diseases and in cancer. Polarity provides a mechanism by which cells produce different types of cells, a critical process for stem cells to maintain tissue homeostasis and for multicellular organisms to develop their complex tissues and organs. This application aims to support a Gordon Research Conference and Research Seminar, which will bring together investigators and students working in this exciting field to share ideas, and to encourage cross-fertilization between basic discovery science and translational research.

PI_NAMEs: YAMASHITA, YUKIKO  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Academia;Address;Adipocytes;Advertising;Architecture;Area;Attention;Behavior;Biological Models;Biology;Cancer Biology;career;Cell Polarity;Cell Shape;cell type;Cells;Cellular biology;Clinical Research;Collaborations;Communities;Complex;Country;Coupling;CRISPR/Cas technology;Data;Defect;Demography;Development;developmental disease;Discipline;Disease;Environment;Exhibits;experience;Face;Faculty;Feedback;Fees;Fellowship;Fertilization;Financial Support;fly;Fostering;Funding;graduate student;Health;Homeostasis;Hour;Human;Imagination;interest;International;Knowledge;Laboratory Organism;Learning;lectures;Malignant Neoplasms;Mechanics;meetings;Mentors;Methods;Minority;model development;model organism;Morphogenesis;multidisciplinary;Mus;Neoplasm Metastasis;Neoplasms;Organ;Organic Synthesis;Organism;Participant;polarized cell;Policies;Postdoctoral Fellow;posters;Process;Productivity;programs;PubMed;Research;Research Personnel;Science;Scientific Societies;Scientist;Signal Transduction;stem cells;Students;symposium;System;Time;tissue regeneration;Tissues;Translational Research;translational study;United States National Institutes of Health;Universities;Variant;virtual;Vision;Woman;Work

PROJECT_TITLE: 2024 Cell Polarity Signaling Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Regenerative Medicine

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The digit tips of many mammals regenerate following amputation, but it is not known how the regenerating cells become a correctly organized and shaped tissue. In the short term, this project will reveal patterning mechanisms in mouse digit tip regeneration and highlight how this may be fundamentally different from non- mammalian limb regeneration models. In the long term, this research will support future human limb regeneration efforts by defining exogenous patterning information that may need to be provided.

PI_NAMEs: LEHOCZKY, JESSICA A (contact)

PROJECT_TERMS: Amputation;Anatomy;Automobile Driving;blastema;cell motility;cell regeneration;cell type;Cells;Computer Models;Connexin 43;Cues;Data;design;digit regeneration;Digit structure;Distal;Dorsal;Embryo;Environment;Epithelium;Fibroblast Growth Factor;Future;gain of function;Gap Junctions;gene function;gene network;Genes;genetic approach;Goals;Human;Intercellular Junctions;limb amputation;Limb Bud;Limb Development;limb regeneration;Limb structure;loss of function;Mammals;Membrane Transport Proteins;Modeling;Molecular;Morphology;Mus;mutant;Nail plate;National Institute of Child Health and Human Development;Natural regeneration;novel;Pathway interactions;Pattern;Proliferating;regeneration model;regenerative;Research;Secondary to;Shapes;Signal Transduction;solute;Sorting;Structure;Testing;tissue regeneration;Tissues;transcriptome sequencing;transcriptomics;Vertebrates;Visualization

PROJECT_TITLE: Composite tissue patterning in mammalian digit tip regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-A (50)]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Patients with neurofibromatosis type 1 (NF1) can present with a severe form a spine deformity that dramatically affects their quality of life. There is no treatment other than invasive, repeated surgical interventions, hence the goal of this study is to identify the cells and main factors in the spine that contribute to this condition, which is necessary to design preventative or better corrective clinical interventions.

PI_NAMEs: ELEFTERIOU, FLORENT  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: 17q;Ablation;Address;Adult;Affect;Appearance;bone;Candidate Disease Gene;Cartilage;Case Management;Cell Lineage;Cells;Chest;Chromosomes;Classification;Clinical;Clinical Management;Clinical/Radiologic;clinically significant;conditional mutant;Coupled;Cutaneous;Defect;Deformity;design;Development;Disease;Disease Progression;Dysplasia;effective therapy;Elements;Embryo;Embryonic Induction;Epiphysial cartilage;Etiology;Foundations;Functional disorder;Future;Genes;Genetic Transcription;Germ Lines;Goals;inducible Cre;insight;Intervention;Intervertebral disc structure;Investigation;Knowledge;KRT19 gene;Kyphosis deformity of spine;Lasers;longitudinal analysis;loss of function;Loss of Heterozygosity;Lytic;Maintenance;Microdissection;Modality;Molecular;mouse model;Mus;Mutant Strains Mice;Mutation;neurofibroma;Neurofibromatosis 1;Neurologic Deficit;NF1 gene;notochord;novel;novel therapeutics;nucleus pulposus;Operative Surgical Procedures;osteoprogenitor cell;paracrine;Pathway interactions;Patients;Penetration;personalized management;personalized therapeutic;Physical condensation;Play;Plexiform Neurofibroma;postnatal;pre-clinical;Prevalence;prevent;Process;Pseudarthrosis;Quality of life;rapid growth;release factor;Repeat Surgery;Reporting;respiratory;rib bone structure;Role;Sampling;Schwann Cells;Sclerotome;scoliosis;Severities;Severity of illness;skeletal;skeletal dysplasia;Skeleton;Speed;Spinal Canal;Spinal Curvatures;spine bone structure;stem cells;Stromal Cells;Testing;Tissues;transcriptome;transcriptome sequencing;tumor;Variant;vertebra body;Vertebral column

PROJECT_TITLE: Characterizing the cell-of-origin for NF1 dystrophic scoliosis

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Prevention;Regenerative Medicine

PHR: Project Narrative The 2024 Gordon Conference on Craniofacial Morphogenesis and Tissue Regeneration will bring together diverse leaders with an interest in human congenital anomalies affecting the head and face. The goal of the conference is to share how research in development, evolution, and regeneration of the vertebrate head can be leveraged toward new approaches to the diagnosis, prevention, and repair of human craniofacial disorders.

PI_NAMEs: CRUMP, GAGE D (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Acceleration;Affect;Animal Model;Big Data;Brain;career;cell type;Cells;Cellular biology;Clinical;Collaborations;Communities;Congenital Abnormality;congenital anomaly;Country;craniofacial;Craniofacial Abnormalities;craniofacial complex;craniofacial development;craniofacial disorder;craniofacial repair;craniofacial structure;craniofacial tissue;data sharing;Defect;Dental;design;Development;Developmental Biology;Diagnosis;Diet;Disease;educational atmosphere;Educational workshop;Embryo;Emerging Technologies;Environmental Risk Factor;Equilibrium;Evolution;Exhibits;Face;FaceBase;Faculty;Financial Support;folic acid supplementation;Fostering;Funding;Gender;Genetic;genetic approach;genome sequencing;Genomics;Geography;Germ Layers;Goals;graduate student;Growth;Head;Hour;Human;Human Development;human stem cells;Image;innovation;insight;Institution;interest;International;Lead;Leadership;meetings;member;Mentors;Metabolic;Metabolism;metabolomics;Methods;Mission;model organism;Modeling;Morphogenesis;National Institute of Child Health and Human Development;National Institute of Dental and Craniofacial Research;Natural regeneration;Nature;Neural Tube Defects;next generation;North America;novel;novel strategies;Oral;Organ;Organism;parity;Participant;Pattern;Play;Population;Positioning Attribute;Postdoctoral Fellow;prevent;Prevention;Productivity;programs;Publications;racial diversity;Radiation;Regulation;repaired;Research;Research Personnel;Resources;Role;Running;Science;Scientist;Sensory;single cell genomics;stem cell technology;stem cells;Structure;Student Selections;symposium;Technology;Therapeutic Intervention;Time;tissue regeneration;Translating;Translational Research;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Variant;Vertebrates;whole genome;Woman;Work

PROJECT_TITLE: Craniofacial Morphogenesis and Tissue Regeneration Gordon Research Conference and Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 YM (09)]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Diabetic retinopathy is the most common complication of diabetes and is a leading cause of vision loss in working-aged adults in the United States. The goal of this proposal is to understand the contribution of innate immunity, specifically leukocyte transmigration, to the development of early diabetic retinopathy. This will not only contribute to our fundamental knowledge of diabetic retinopathy pathogenesis, but also elucidate targets for developing therapy for early-stage disease, for which there are currently no treatments.

PI_NAMEs: FANG, VIVIENNE  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Acute;Address;Adhesions;Adult;advanced disease;aged;Anatomy;Antibodies;Apoptosis;Background Diabetic Retinopathy;Blindness;Blood;Blood capillaries;Blood Vessels;CASP3 gene;CCL2 gene;CD31 Antigens;cell injury;chemokine;Classification;Complications of Diabetes Mellitus;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Retinopathy;Disease;Disease Progression;Dropout;Early treatment;Endothelial Cells;Endothelium;Extravasation;fovea centralis;Functional disorder;gamma-Chemokines;glial activation;Goals;Hemorrhage;Histologic;Hyperglycemia;Immunofluorescence Microscopy;improved;in vivo imaging;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Intercellular adhesion molecule 1;intravital microscopy;intravitreal injection;Ischemia;Knowledge;Leucocytic infiltrate;Leukocytes;Leukostasis;Ligands;Liquid substance;Literature;Macrophage;macula;macular edema;Measures;Mediating;Methods;Microaneurysm;Microvascular Dysfunction;migration;Modeling;monocyte;mouse model;Mus;Myeloid Cells;Natural Immunity;neovascularization;neutrophil;new growth;novel therapeutics;occludin;Outcome Measure;Oxygen;Pathogenesis;Patients;Phenotype;prevent;proliferative diabetic retinopathy;receptor;recruit;Research;Retina;retinal damage;Retinal Detachment;Rodent;Rodent Model;Role;Sampling;Streptozocin;System;Testing;therapy development;Tight Junctions;Time;Tissues;Traction;United States;Vascular Permeabilities;Vasculitis;venule;Visualization;Vitreous Hemorrhage

PROJECT_TITLE: The Role of Myeloid Cell Transendothelial Migration in Non-Proliferative Diabetic Retinopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Schizophrenia;Serious Mental Illness;Social Determinants of Health;Telehealth

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

ORG_STATE: CA

PHR: Project Narrative The proposed research has high public health relevance because (1) we focus on Medicaid beneficiaries with schizophrenia, bipolar disorder, and severe major depressive disorder, a seriously mentally ill population with overrepresentation of racial/ethnic minorities for whom access to high-quality and equitable care may be transformative, yet poor quality, quality disparities, and low value care are rampant, and (2) successful completion of our aims will provide policymakers with race/ethnicity-infused evidence regarding (a) groups to be targeted for interventions to improve quality of care, (b) the effects of high-quality care on key patient outcomes, (c) the effects of telemental health policies, and (d) the comparative effects of alternative quality- improving interventions on outcomes of high significance to patients, state policymakers, and society.

PI_NAMEs: HORVITZ-LENNON, MARCELA V (contact);NORMAND, SHARON-LISE TERESA

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: Address;Adoption;Adult;Affect;Algorithms;Alternative Therapies;Area;authority;beneficiary;Bipolar Disorder;burden of illness;Caring;Characteristics;cohort;comorbidity;comparative;cost;cost outcomes;COVID-19 pandemic;Data;Data Set;Diagnosis;disability;Disparity;Equity;ethnic disparity;Ethnic equity;ethnic minority;Ethnic Origin;Funding;Goals;Health;Health Care Costs;Health Policy;Health Services Accessibility;Healthcare;high risk;Homelessness;improved;Individual;Inequity;innovation;Intervention;Life Expectancy;Link;Literature;Machine Learning;machine learning algorithm;Major Depressive Disorder;Measurement;Measures;Medicaid;Medical;Mental Health;Mental Health Services;Mentally Ill Persons;Methods;National Institute of Mental Health;New York;New York City;novel;Outcome;patient subsets;Patient-Focused Outcomes;Patients;payment;Persons;physical conditioning;Policies;Policy Analysis;Policy Maker;Population;Process;programs;Provider;Public Domains;Public Health;public health relevance;Quality of Care;Quasi-experiment;Race;racial disparity;racial minority;Reporting;Research;Risk;Schizophrenia;severe mental illness;social;social health determinants;Social outcome;Societies;stem;Strategic Planning;suicidal;telehealth;Telemental;Underserved Population;Visit

PROJECT_TITLE: Addressing Gaps in the Evidence to Improve Quality, Equity, and Value of Serious Mental Illness Care in Medicaid

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Lung;Machine Learning and Artificial Intelligence;Pulmonary Fibrosis

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative: Pulmonary fibrosis is a progressive and deadly disease, with a prognosis worse than many aggressive cancers. Early detection and treatment of pulmonary fibrosis is critical to improve patient outcomes and is an important public health priority, but is currently unachievable due to the limitations of standard testing methods. The goal of this proposal is to investigate the use of a low-risk, minimally-invasive, microscopic optical bronchoscopy tool to accurately detect early pulmonary fibrosis at the presymptomatic stages, before significant lung destruction has occurred, which would allow for early treatment and improve patient outcomes.

PI_NAMEs: HARIRI, LIDA P (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: 3-Dimensional;Adverse event;antifibrotic treatment;Architecture;Artificial Intelligence;artificial intelligence method;automated segmentation;Biological Markers;Biopsy;Bronchoscopes;Bronchoscopy;Catheters;CCL18 gene;CHI3L1 gene;Clinical;Clinical Trials;cohort;computed tomography screening;cost;Data;Death Rate;density;Derivation procedure;Detection;Development;Disease;Disease Progression;Early Diagnosis;Early treatment;Evaluation;Family history of;feature detection;Fibrosis;fibrotic interstitial lung disease;follow-up;Funding;Future;Goals;High Resolution Computed Tomography;high risk;Histologic;idiopathic pulmonary fibrosis;Image;imaging biomarker;imaging modality;Imaging technology;improved;improved outcome;indexing;Individual;individual patient;insight;interstitial;Link;Lung;Lung CAT Scan;Lung Diseases;lung imaging;Lung nodule;Malignant Neoplasms;Manuals;Matrilysin;Methods;Microscopic;microscopic imaging;Microscopy;minimally invasive;Modeling;Morbidity - disease rate;mortality;mortality risk;Natural History;novel;novel therapeutics;Operative Surgical Procedures;Optical Coherence Tomography;Optics;Outcome;overtreatment;Patient risk;Patient-Focused Outcomes;Patients;Persons;Plasma;Positioning Attribute;predictive modeling;Prognosis;prognostic;progression risk;public health priorities;Pulmonary Fibrosis;pulmonary function decline;radiological imaging;Randomized, Controlled Trials;Reader;Regression Analysis;Reporting;Research Personnel;Resolution;Risk;screening program;Sensitivity and Specificity;Site;Smoker;Specimen;Structure of parenchyma of lung;Technology;technology validation;Testing;Therapeutic;Thinness;Tissues;tool;Traction;United States National Institutes of Health;Validation

PROJECT_TITLE: Microscopic EB-OCT imaging to predict progression in interstitial lung abnormalities

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE We propose a research education program entitled, “Developing Research Leaders in Global Infectious Diseases in Women” to address critical knowledge and research training gaps in global infectious diseases that disproportionately cause morbidity and mortality in women in the US and internationally. The program includes a comprehensive scientific course taught by leading experts in the field and a longitudinal career development program. This program will not only cultivate scientific collaboration and innovation in this field but will also develop the next generation of researchers committed to improving global infectious disease health outcomes in women.

PI_NAMEs: DOWNS, JENNIFER ALZOS (contact);MATHAD, JYOTI S;MCNAIRY, MARGARET LEIGHTON

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Address;Advisory Committees;Affect;Age;Basic Science;Behavioral;Biological;Biology;career;career development;Clinical Investigator;cohort;Collaborations;Communicable Diseases;Communities;Complement;Complex;Country;Data;Diagnosis;Disparity;Education;education research;Educational process of instructing;Educational Status;Educational workshop;experience;Faculty;Female;Female Adolescents;Funding;girls;global health;Goals;Grant;Haiti;Health;high risk;HIV;HIV Infections;HIV/AIDS;Home;Immune;Immune response;Immunology;Impaired health;improved;India;Individual;Infection;Infectious Diseases Research;innovation;Institution;interest;International;Knowledge;Leadership;leadership development;lectures;life span;low income country;Malaria;men;Mentors;Mentorship;Methodology;Mission;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;National Institute of Allergy and Infectious Disease;New York;next generation;novel;pathogen;Pathogenesis;peer;peer support;poor health outcome;Predisposition;Pregnant Women;prevent;Prevention;Program Development;programs;recruit;Research;Research Personnel;Research Priority;Research Training;Respiratory Tract Infections;respiratory virus;Scholars Program;Scientist;Seminal;Sex Differences;Site;social;social determinants;social health determinants;stem;Structure;symposium;Tanzania;Technical Expertise;tool;Training;Training and Education;Training Programs;Translational Research;Underrepresented Minority;United States;United States National Institutes of Health;Viral Load result;Vocational Guidance;Woman;Women's Health;Women's mortality;women's outcomes;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 PP-D (M1)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: DURHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Public Health Relevance The proposed studies will investigate cellular and physiological mechanisms regulating cell volume and cell integrity in notochord vacuolated cells and in vacuolated cells rom the nucleus pulposus of intervertebral discs (IVD). These studies are relevant for the understanding of spine biology and IVD disease.

PI_NAMEs: BAGNAT, MICHEL  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Acute;Adhesions;Animals;Anions;Biological;Biological Assay;Biology;Biophysical Process;Buffers;Calcium Channel;Calcium Signaling;Cell Communication;Cell Physiology;Cell Size;Cell Volumes;Cells;Chloride Channels;Cues;Cyclic AMP;Cystic Fibrosis Transmembrane Conductance Regulator;Cytoplasm;Data;Development;diagnostic tool;Disease;Embryo;Embryonic Development;experimental study;Feedback;G-Protein-Coupled Receptors;Genetic;Growth;Homeostasis;Hydrogels;in vivo;Individual;Intervertebral disc structure;Ion Channel;Knowledge;Liquid substance;Lysosomes;Mammals;mechanical force;mechanical properties;mechanical signal;Mechanics;Mediating;Methods;Modeling;notochord;novel;nucleus pulposus;Organ;Organelles;Organism;Osmosis;Outcome Study;particle;Pathway interactions;Pattern;Phosphorylation;Physiological;Piezo 1 ion channel;Process;public health relevance;Regulation;response;Role;scaffold;Signal Transduction;sodium-potassium-chloride cotransporter 1 protein;Swelling;System;Testing;therapy development;Tissues;Tube;Vacuole;Vertebral column;Vertebrates;Work;Zebrafish

PROJECT_TITLE: Investigating mechanisms of cell volume regulation in the zebrafish notochord

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-C (02)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PHR: Project Narrative The goal of the Centromere Biology conference is to substantially advance our understanding of the centromere regions of each chromosome by convening researchers from diverse disciplines focusing on this genomic locus. This meeting will bring together outstanding scientists interested in understanding different aspects of centromere properties including the sequence, nature, organization, evolution (including sequence diversity across the human population), and function of this important and unique genomic locus. This meeting will also strive to build an inclusive and diverse centromere community.

PI_NAMEs: MELLONE, BARBARA  (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TITLE: 2024 Centromere Biology Gordon Research Conference

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (J2)]


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE The proposed studies are in the area of electrical microstimulation for neuroprostheses, which has potential applications in many human diseases or injuries. Our work will further advance research by generating transformative and efficacious software and hardware technology that will be used widely throughout the research community. Thus, the proposed research is relevant to the translational focus of the NIH's mission and will potentially help to reduce the burdens of human disability.

PI_NAMEs: ORAZEM, MARK E.;OTTO, KEVIN J. (contact)

PROGRAM_OFFICER_NAME: HWANG, GRACE MEI-HUA

PROJECT_TERMS: Address;Area;Charge;Communities;Computer Models;Computer software;design;disability;Electric Stimulation;electrical microstimulation;Elements;Engineering;Evaluation;Goals;Human;human disease;in vivo;Injury;innovation;Measurement;Microelectrodes;microstimulation;Mission;Modeling;Nervous System;neural;neuroprosthesis;neuroregulation;Neurosciences;Outcome Assessment;Performance;Research;Resolution;Technology;temporal measurement;Testing;tool;United States National Institutes of Health;user-friendly;Work

PROJECT_TITLE: Administrative Diversity Supplement


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Lymphatic Research;Lymphedema;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The lymphatic vasculature provides crucial functions for the maintenance of homeostasis in a variety of tissues and organs by providing the primary route through which immune cells, large proteins, lipids, and interstitial fluid are returned to the blood circulation. This proposed work seeks to utilize drug delivery strategies to 1) enhance lymphatic pumping via pharmacologic modulation of ion channels within the lymphatic muscle of the intact vasculature and 2) reduce the local inflammation through targeted immunomodulator delivery locally and to the lymph node downstream of the site of lymphedema. Findings from this work will lead to a new class of therapeutic strategies for regional enhancement of lymphatic pump function and reducing inflammation in lymphedema.

PI_NAMEs: DIXON, JAMES BRANDON;THOMAS, SUSAN NAPIER (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Acute;Animals;biocompatible polymer;Biodistribution;Blood;Blood Circulation;Blood Vessels;Breast Cancer survivor;Calcineurin;Calcineurin inhibitor;Calcium Channel Agonists;cancer therapy;Cells;channel blockers;Chronic;chronic pain;Complex;controlled release;design;Developed Countries;Diagnosis;Disease;Disease Progression;Dose;draining lymph node;Drug Delivery Systems;Drug Formulations;Drug Targeting;Drug Utilization;expectation;Failure;Fatigue;Fibrosis;fluorescence imaging;Functional disorder;Genetic Models;Health Care Costs;Homeostasis;Human;human disease;imaging capabilities;Immune;immune modulating agents;immunodeficiency;Immunomodulators;improved;In Situ;in vivo;Incidence;Infection;Inflammation;Inflammatory;inhibitor;Injections;insight;Intercellular Fluid;Ion Channel;L-Type Calcium Channels;Life;Life Expectancy;Ligation;Limb structure;Lipids;Liquid substance;Longevity;Lymph;lymph nodes;Lymphatic;lymphatic circulation;lymphatic drainage;Lymphatic function;lymphatic pump;Lymphatic System;lymphatic vasculature;lymphatic vessel;Lymphedema;Maintenance;Malignant Breast Neoplasm;Mastectomy;Measures;Mental Depression;Methods;Micelles;Microsurgery;Modeling;Molecular;mouse model;Mus;Muscle;Near-infrared optical imaging;novel;novel therapeutics;Operative Surgical Procedures;Organ;Outcome;Pathogenesis;Pathologic;Pathological anxiety;Pathology;Patient Compliance;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Philosophy;Physiology;Population;Population Dynamics;Populations at Risk;Potassium Channel;Potassium Channel Blockers;Pre-Clinical Model;pressure;Prevalence;prevent;programs;Proteins;Pump;Rattus;reduce symptoms;Research;Rodent Model;Route;Sentinel Lymph Node Biopsy;Sheep;sheep model;Signal Transduction;Site;Skin;Spleen;Surgical Models;Survivors;Swelling;synergism;Syringes;System;Technology;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Tissues;Tracer;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Transgenes;Transplantation;Vascularization;Work

PROJECT_TITLE: Lymphedema therapy via lymphatic targeted drug delivery

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NOT APPLICABLE no PHR

PI_NAMEs: ARCHIBALD, AHLINA  (contact)

PROGRAM_OFFICER_NAME: YABE, IDALIA MONTANO

PROJECT_TITLE: MSPP Application

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-U (22)]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: Project Narrative The focus of this proposal is on CNS demyelination, which is a critical aspect of numerous neurological conditions. Oligodendrocytes and myelin are lost in many neurological disorders, such that their protection and replacement would likely be of considerable therapeutic value. The studies described in this proposal are designed to increase our understanding of CNS demyelination: how oligodendrocytes respond to cytotoxic stimuli, how they can be protected against harsh, disease-associated conditions, and how they can be replaced so that lost myelin can be reformed.

PI_NAMEs: POPKO, BRIAN J (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Ablation;Acute;Autoimmune;Award;Axon;axon injury;biological adaptation to stress;Biology;cytotoxic;Demyelinations;design;Development;Disease;Electrophysiology (science);Functional disorder;Funding;Genetic;Inflammatory;Innate Immune Response;insight;Messenger RNA;Methylation;Microglia;Modeling;Molecular;mouse model;Multiple Sclerosis;Mus;Myelin;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurologic;Oligodendroglia;Process;Proteins;remyelination;repaired;Research;Role;Stimulus;Therapeutic;Zinc Fingers

PROJECT_TITLE: CNS Demyelination: Initiation, Protection, and Correction

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-D (35)]


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Congenital Structural Anomalies;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Infectious Diseases;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: COLUMBIA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Zika virus (ZIKV) infection has been linked to congenital glaucoma; however, the molecular mechanisms of the disease are still unknown. Thus, elucidating pathological mechanisms underlying TM dysfunction in ZIKV-induced glaucoma is paramount to identifying key pathways for therapeutic development. This study will use human primary trabecular meshwork cells (HTMC) and mouse neonate pups and congenital infection models to investigate the role of ZIKV infection in the pathobiology of glaucoma.

PI_NAMEs: SINGH, PAWAN KUMAR  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Affect;age-related disease;Anterior;Anterior eyeball segment structure;Antibodies;Antibody-Dependent Enhancement;Atrophic;Autophagocytosis;Axonal Transport;biological adaptation to stress;Case Study;Cell Death;Cell model;Cells;Cessation of life;Choroid;Clinical;combat;congenital infection;Country;Development;Disease;endoplasmic reticulum stress;Epidemic;Exhibits;Exposure to;Extracellular Matrix;FDA approved;Flavivirus;Functional disorder;Future;Genetic;Glaucoma;global health;Goals;Human;Hydrophthalmos;Hydroxychloroquine;Hypoxia;IFNAR1 gene;In Vitro;in vivo Model;Infant;Infection;Laboratories;Link;Mediating;Microcephaly;Modeling;Molecular;Mothers;mouse model;Mus;neonate;nerve damage;Newborn Infant;novel;offspring;Optic Nerve;Pathogenesis;pathogenic virus;Pathologic;Pathology;Pathway interactions;Pharmaceutical Preparations;Physiologic Intraocular Pressure;Posterior eyeball segment structure;Pregnancy;prognostic;pup;Reporting;Retina;Retinal Ganglion Cells;Role;Testing;Therapeutic;therapeutic development;therapeutic target;tool;Trabecular meshwork structure;transcriptome sequencing;transcriptomics;transmission process;Treatment Efficacy;Zika Virus;ZIKV infection

PROJECT_TITLE: Role of Zika virus (ZIKV) infection in glaucoma pathobiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(81)-S]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Congenital Structural Anomalies;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Pediatric;Rare Diseases

ORG_CITY: Aurora

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Hirschsprung-associated enterocolitis (HAEC) is a life-threatening complication of Hirschsprung Disease, a common cause of intestinal obstruction in the newborn that results from incomplete development of the enteric nervous system. The etiology of HAEC is poorly defined and current treatment remains empiric and directed toward alleviating acute symptoms rather than targeting underlying pathophysiology. This proposal will define the role of dysbiosis in the pathophysiology of HAEC and test novel therapeutic approaches for prevention or treatment of HAEC.

PI_NAMEs: GOSAIN, ANKUSH  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Acetylcholine;acute symptom;Affect;Animals;Antibiotics;Automobile Driving;Bacteria;Cellular biology;Cessation of life;Colitis;Complication;Congenital Megacolon;Data;Development;Disease;Down-Regulation;dysbiosis;Endocrinology;Endothelin B Receptor;Enteric Nervous System;Enterocolitis;Epithelial Cells;Etiology;Exclusion;fecal transplantation;Functional disorder;gastrointestinal;Gnotobiotic;Goals;gut inflammation;Host Defense;host microbiome;Immune Evasion;Immunoglobulin A;Immunoglobulins;Impairment;improved;Incidence;Infant;Inflammatory Bowel Diseases;innovation;intestinal epithelium;Intestinal Motility;Intestinal Obstruction;Intestines;Laboratories;Lactobacillus;Lactobacillus plantarum;Large Intestine;Life;Maps;member;Methodology;microbial;microbiome;microbiota;Morbidity - disease rate;mortality;Motility;motility disorder;mouse model;Mus;mutualism;Neural Crest;neurochemistry;Neurotransmitters;Newborn Infant;novel;novel therapeutic intervention;operation;Operative Surgical Procedures;Outcome Study;pathobiont;Pathogenesis;Pathway interactions;Patients;Physiological;Polymeric Immunoglobulin Receptors;Postoperative Period;Pre-Clinical Model;Prevention approach;Production;Psychological reinforcement;Publishing;Qualifying;receptor expression;Rectum;Research;Rest;Role;Sampling;Secretory Immunoglobulin A;Small Intestines;spatiotemporal;Surgical Models;targeted treatment;Testing;therapeutic target;Transgenic Animals

PROJECT_TITLE: Dysbiosis in Hirschsprung Associated Enterocolitis Pathogenesis


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Dementia;Health Services;Intellectual and Developmental Disabilities (IDD);Mucopolysaccharidoses (MPS);Neurodegenerative;Neurosciences;Orphan Drug;Patient Safety;Pediatric;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: BROOKLYN

ORG_NAME: PHOENIX NEST, INC.

PHR: Project Narrative Our enzyme replacement therapy program has achieved goals set on Phase I STTR, Phase II SBIR and continuing to make strides towards achieving our goals for Phase II SBIR. To support IND filing and initiation of the interventional clinical trial we need this CRP grant to support execution of this trial for identification of critical measurable clinical outcome and potential biomarkers. These data will ultimately support commercialization the first therapy for MPS IIID.

PI_NAMEs: SINGAMSETTY, SRIKANTH  (contact)

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Affect;Brain;Cessation of life;Childhood;Clinic;Clinical;clinical outcome assessment;clinical predictors;Clinical Protocols;Clinical Services;Clinical Trials;CLN2 gene;commercialization;Contract Services;Data;Data Collection;Dementia;design;Development;Diagnosis;Disease;efficacy evaluation;enzyme replacement therapy;Enzymes;experience;Goals;Grant;Human;Immobilization;Impaired cognition;Individual;Infusion procedures;Intervention;Intervention Studies;Intervention Trial;Investigational Therapies;Legal patent;Letters;Licensing;manufacture;Measurable;Measures;Monitor;Motor Skills;Mucopolysaccharidoses;Mucopolysaccharidosis I;Mucopolysaccharidosis II;Mucopolysaccharidosis III;Natural History;Nerve Degeneration;Neurologic;Neurologic Symptoms;Outcome;Pathologic;Pathology;patient population;Patients;Phase;phase I trial;potential biomarker;Preparation;primary endpoint;Problem behavior;programs;Quality of life;Recombinants;Recommendation;research clinical testing;service providers;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Spielmeyer-Vogt Disease;success;Sulfatases;Time;tool;Universities;Work

PROJECT_TITLE: Evaluation of Clinical Outcome Assessment (COA) and Potential Biomarkers to Facilitate Interventional Trial for Mucopolysaccharidosis IIID Patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(19)-B]


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Pediatric;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE The Biology of Climate Change: Impacts on Human Health and the Science of Solutions project will educate secondary students and teachers about the ways in which climate change is affecting health. The overarching goal is to build students’ knowledge of in-progress solutions and introduce them to related biomedical careers.

PI_NAMEs: FENKER, KRISTIN  (contact);STARK, LOUISA A

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Achievement;Address;Affect;Air Pollution;animation;Automobile Driving;Award;Belief;Biological Sciences;Biology;Biomedical Research;career;Career Choice;Climate;climate change;climate impact;climate-related health;Collaborations;Complex;course development;curriculum development;design;digital media;E-learning;Earth science;Education;education resources;Educational Curriculum;Educational process of instructing;Educational workshop;efficacy study;Evaluation;Event;experience;flexibility;Friends;Future;Genetic;Goals;Health;health literacy;high school;High School Faculty;High School Student;Human;improved;Individual;innovation;Instruction;interactive multimedia;Internet;junior high school;K-12 science education;K-12 student;Knowledge;Learning;lens;literacy;Medical;Methods;Multimedia;online course;Online Systems;Planets;Population;pressure;Printing;Problem Solving;Program Development;Publishing;Research;research study;response;Risk;Schools;Science;science education;Science of genetics;science teacher;skills;Students;symposium;teacher;Teacher Professional Development;Testing;Textbooks;tool;Training Programs;Underrepresented Populations;Universities;Utah;Visit;web site;Writing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (55)]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: AUSTIN

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE/RELELVANCE TO PUBLIC HEALTH. Violence in the United States is the third leading cause of death for young people (aged 10 to 24 years), and violent acts have immediate, enduring, and disturbing impacts on individuals, families, and communities. Youth violence is a problem in other countries in our hemisphere as well, and one area of particular concern is Central America. The proposed study seeks to examine the impact of Miles de Manos (MdM; “Thousands of Hands”), a universal, multi-modal, evidence-informed and community-based youth violence prevention intervention, on youth violence in Honduras. Potential benefits of the project include filling in gaps in knowledge about community-based violence prevention programs both in Honduras and the U.S.; finding effective ways to improve the health, safety, and social cohesion of community members has the potential to benefit both countries in numerous ways, including reducing the personal and social disruptions and traumas that come from living in and leaving communities that become marked by violence.

PI_NAMEs: EDDY, JOHN MARK (contact);MARTINEZ, CHARLES R

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Address;Adopted;Adult;Affect;Age;aged;Agency for International Development;Area;Attention;Behavior;Caregivers;Cause of Death;Central America;Central American;Child;Child Rearing;cohesion;Collaborations;Communities;Complex;Country;Crime;Data;Development;Distant;Education;education planning;Effectiveness;effectiveness evaluation;efficacy testing;El Salvador;elementary school;Epidemic;Ethnic Population;Evaluation;evidence base;experience;Family;feasibility trial;fighting;firearm access;Funding;gang;German population;Guatemala;Hand;Health;high risk;Honduran;Honduras;improved;Individual;International;Intervention;Knowledge;Latin America;Latin American;Latino;Latino Population;Learning;Left;Link;Location;Mediator;member;Migrant;Mind;Minor;multimodality;Neighborhoods;Nongovernmental Organizations;Outcome;Parents;peer;Personal Satisfaction;Persons;Pharmaceutical Preparations;Population;Poverty;Practice Management;Prevention;Prevention program;preventive intervention;Problem behavior;programs;protective factors;Public Health;racial population;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Risk Factors;Safety;School-Age Population;Schools;Security;social;social cognitive theory;social cohesion;Social Controls;Social Environment;Societal Factors;Specific qualifier value;Students;teacher;Testing;Touch sensation;trafficking;Trauma;Underemployment;United States;Victimization;Violence;violence prevention;War;Work;young man;Youth;youth violence;youth violence prevention

PROJECT_TITLE: Miles de Manos: Testing the Efficacy of a School-Based Youth Violence Preventive Intervention in a High Risk International Context

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Urologic Diseases

ORG_CITY: WHITE RIVER JUNCTION

ORG_NAME: VETERANS EDUCATION/RES/ASSN/NORTH/NE

ORG_STATE: VT

PHR: Project Narrative We will systematically study whether the burden of surveillance cystoscopy can be improved among bladder cancer survivors by replacing invasive cystoscopy with urine testing, ultimately improving their quality of life. We propose a three-site randomized phase 2 trial including 240 patients with early-stage bladder cancer, in which patients will be randomized 1:1:1 to programmatic surveillance with the Xpert bladder cancer urine test, the Bladder EpiCheck urine test, or standard cystoscopy. The primary outcome will be urinary quality of life 1 to 3 days after surveillance, with secondary outcomes including discomfort after surveillance measured on a Visual Analogue Scale, anxiety, number of invasive tests performed and of complications per 1,000 patient years, and the cumulative incidence of recurrence and progression at 12 and 24 months.

PI_NAMEs: SCHROECK, FLORIAN R (contact)

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: Affect;analog;Anxiety;arm;Bladder;cancer recurrence;Cancer Survivor;comparative;comparative effectiveness trial;Cystoscopes;Cystoscopy;Data;DNA Methylation;Dropout;efficacy evaluation;Enrollment;Evaluation;Excision;follow-up;Goals;Guidelines;improved;Incidence;interest;Intervention;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;Messenger RNA;methylation testing;Modeling;Monitor;non-muscle invasive bladder cancer;Outcome;patient oriented;Patients;Pattern;phase II trial;Population Heterogeneity;primary outcome;Procedures;Quality of life;Randomized;Recommendation;Recurrence;Regimen;routine care;Safety;safety and feasibility;safety outcomes;screening;secondary outcome;sex as a biological variable;Site;Specificity;Testing;Time;tumor progression;Urethra;urinary;Urine;validation studies;Visual;Work;Writing

PROJECT_TITLE: Replacing Invasive Cystoscopy with Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-G(90)S]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision

PHR: PROJECT NARRATIVE Impairment of ocular lens transparency and tensile properties leads to cataract and presbyopia, respectively, the two leading causes of visual impairment. This proposal focuses on determining the role of S100A4 in regulation of non-muscle myosin IIA (NM IIA) function, since NM IIA mutations are associated with cataract formation in human patients. The studies in this proposal will also decipher the mechanistic basis by which absence of S100A4, a calcium and NM IIA binding protein, induces cataract formation in a mouse model. We know very little about the role played by the S100 family of proteins in lens function despite their relatively abundant expression in the lens. We expect the studies proposed in this application to unravel the role of S100A4 and its related proteins in normal lens function and physiology as well as in cataract development.

PI_NAMEs: RAO, P VASANTHA (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Actins;Actomyosin;Address;adducin;Adhesives;Affect;aquaporin 5;Architecture;Binding Proteins;Biochemical;Calcium;Calcium Binding;Calcium-Binding Proteins;Cataract;Cell Adhesion;cell motility;cell type;Cells;Characteristics;Compensation;Crystalline Lens;Cytoskeletal Modeling;Cytoskeleton;Data;Defect;Development;Disease;EF Hand Motifs;Embryo;EMS1 gene;Epithelium;Equilibrium;Etiology;Exhibits;Family;Fiber;fiber cell;Fibrosis;Functional disorder;Gene Expression;Generations;Genes;Growth;Homeostasis;Human;Impairment;Integrins;interest;Knockout Mice;Knowledge;lens;Lens Fiber;lens intrinsic protein MP 70;lens transparency;Light;Maintenance;Malignant Neoplasms;mechanical properties;Mechanics;member;Membrane;migration;Molecular;Molecular Chaperones;Motor;mouse model;Mus;Muscle;mutant;Mutation;Myosin ATPase;Myosin Type II;Neoplasm Metastasis;Neurons;non-muscle myosin;Nonmuscle Myosin Type IIA;Nonmuscle Myosin Type IIB;novel;old mice;Osmoregulation;Osmosis;Pathway interactions;Patients;Phenothiazines;Phenotype;Phosphorylation;Physiological;Physiology;Play;polymerization;Polymers;Presbyopia;Prevention;Property;Proteins;Proteomics;radixin protein;Regulation;Retina;Role;S100 Proteins;S100A4 gene;Signal Transduction;Smooth Muscle;solute;Stress Fibers;Testing;Tissues;transcriptome;Transgenic Organisms;Up-Regulation;Visual impairment;Wild Type Mouse;α-Crystallins

PROJECT_TITLE: Role of the S100 Family of Proteins in Lens Physiology and Cataract

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Cancer

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE Our preliminary results have revealed a previously unrecognized protein quality control (PQC) system in mammalian cells, whose up-regulation contributes to tumorigenesis. The proposal will determine the mechanism of action of newly discovered PQC system, its role in formation and progression of cancer, and the utility of targeting this system, alone or together with the proteasome, for tumor therapy. The proposal will significantly advance our understanding of an emerging trait of cancer cells and will likely inform cancer therapy.

PI_NAMEs: YANG, XIAOLU  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Address;Amino Acid Motifs;Animal Model;Animals;Antioxidants;Binding;Caenorhabditis elegans;cancer cell;cancer initiation;cancer therapy;carcinogenesis;Cell Death;Cell model;Cells;Characteristics;Clinical;Crowding;Development;effective therapy;Environment;Evolution;Excision;Goals;Growth;Human;Impairment;Knowledge;Life;macromolecule;Maintenance;Malignant Neoplasms;malignant phenotype;Mammalian Cell;Mediating;member;misfolded protein;Molecular;Molecular Conformation;multicatalytic endopeptidase complex;Mus;neoplastic cell;Normal Cell;novel;Oncogenic;Oxidative Stress;PML gene;Process;Production;Proliferating;Proteasome Inhibition;Proteasome Inhibitor;protein degradation;protein folding;protein misfolding;Proteins;Proteolysis;proteostasis;Quality Control;Role;Signal Transduction;Stress;Sumoylation Pathway;System;Testing;trait;TRIM Motif;TRIM11 gene;tumor;tumor progression;tumorigenesis;ubiquitin ligase;Ubiquitination;Up-Regulation;virtual

PROJECT_TITLE: A novel protein quality control system and its role in tumorigenesis

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE This grant proposal aims to improve our understanding of craniosynostosis by expanding on our prior work using machine learning methodologies to objectively quantify the head shape anomalies in this condition. During the project, we will further develop a point-of-care tool, CranioRate™, to allow physicians to improve their understanding of their patients and create an accessible collection of imaging data so researchers can more easily study this challenging population of patients. With this information, surgeons will be able to better tailor their interventions to the needs of their individual patients, and researchers will improve their understanding of this complex disorder.

PI_NAMEs: ELHABIAN, SHIREEN YOUSSEF (contact);GOLDSTEIN, JESSE AARON

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Adverse effects;Affect;Age;Algorithms;Applications Grants;Area;Blindness;Cephalic;Childhood;Clinical;clinical center;Clinical Data;clinically relevant;cloud based;Collaborations;Collection;Compensation;Complex;Counseling;Craniosynostosis;cranium;Data;data integrity;Data Set;Databases;Decision Making;design;Development;Diagnosis;Disease;Dysmorphology;Ensure;Evaluation;FaceBase;Family;Future;Goals;Grant;Growth;Head;Human;human imaging;Image;imaging modality;Impairment;improved;individual patient;infancy;Infant;insight;Intervention;Intracranial Hypertension;Investigation;Joint structure of suture of skull;Lead;Left;Machine Learning;machine learning algorithm;machine learning method;machine learning model;Measures;Morphology;Neurocognition;Neurocognitive;Neurocognitive Deficit;novel;Operative Surgical Procedures;Outcome;Pathology;Patient Care;Patient imaging;patient population;Patients;Pattern;Phenotype;Photography;Physicians;Pilot Projects;point of care;Population;Postoperative Period;premature;prevent;Process;prospective;prototype;Recommendation;Reconstructive Surgical Procedures;Reporting;repository;Research;Research Design;Research Personnel;Research Project Grants;Risk;risk stratification;Scanning;Security;self esteem;Severities;shape analysis;Shapes;Socialization;standard of care;Statistical Models;Surface;Surgeon;suture fusion;System;Systems Analysis;Techniques;Technology;Three-dimensional analysis;tool;United States;Variant;Vision;Visual;web portal;Work;X-Ray Computed Tomography

PROJECT_TITLE: CranioRate: An imaging-based, deep-phenotyping analysis toolset, repository, and online clinician interface for craniosynostosis

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Immunotherapy;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PI_NAMEs: CHESNEY, JASON A.;NAIR, SHARMILA  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Address;Antigen Presentation;antitumor effect;Automobile Driving;Cancer Center;cancer immunotherapy;CD8-Positive T-Lymphocytes;Combined Modality Therapy;Dendritic Cells;draining lymph node;Environment;Failure;FLT3 ligand;Glioblastoma;Goals;Immune;Immunotherapy;Inflammatory;Maps;monocyte;Myeloid Cells;novel;oncolytic virotherapy;Oncolytic viruses;programs;Research;response;Role;Solid Neoplasm;stem cells;T cell response;Therapeutic;Tropism;tumor;tumor immunology;tumor microenvironment;Zika Virus

PROJECT_TITLE: Leveraging Zika virus driven myeloid cell responses to treat GBM


ADMINISTERING_IC: ES

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Endocrine Disruptors;Genetics;Health Effects of Indoor Air Pollution;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative Whether indoor flame retardant toxicants, polybrominated diphenyl ethers (PBDEs) contribute to the risk of neurodevelopmental disorders (NDDs) is suspected but not established. Our lab was one of the first to characterize social recognition deficits in mice exposed to the commercial PBDE mixture, DE-71, at low doses. The ultimate goal of the proposed studies is to examine the role of PBDEs on the brain’s oxytocinergic system and whether it is dependent on thyroid hormone and will have broad implications in terms of establishing a link between chemicals and NDDs.

PI_NAMEs: KOZLOVA, ELENA V (contact)

PROGRAM_OFFICER_NAME: LAWLER, CINDY P

PROJECT_TERMS: Adolescent;Affect;Age;Amygdaloid structure;Animals;autism spectrum disorder;autism symptoms;Behavior;Behavioral Assay;Biological;Biological Assay;Brain;Centers for Disease Control and Prevention (U.S.);Chemical Exposure;Chemicals;Child;critical developmental period;Cues;Data;debilitating symptom;Development;developmental neurotoxicity;Disease;disorder risk;Dose;early life exposure;Emotional;emotional behavior;Emotions;Endocrine Disruptors;Environment;Environmental Exposure;Environmental Risk Factor;epidemiology study;Exposure to;Female;Flame Retardants;Genes;Genetic;Genetic Predisposition to Disease;Genetic Risk;Goals;Human;Human Milk;Hypothalamic structure;immunoreactivity;Incidence;Individual;interdisciplinary approach;interest;Knowledge;Link;male;malformation;Mediating;memory recognition;Mental disorders;modifiable risk;Molecular;mouse development;mouse model;Mus;Mutate;National Institute of Mental Health;neural circuit;Neuroanatomy;neurochemistry;neurodevelopment;Neurodevelopmental Deficit;Neurodevelopmental Disorder;neurodevelopmental effect;Neurons;Neuropeptides;novel;novel strategies;Odors;offspring;Oxytocin;Oxytocin Receptor;paraventricular nucleus;Pathogenesis;Perinatal;persistent organic pollutants;Pharmaceutical Preparations;Phenotype;polybrominated diphenyl ether;Predisposition;Prevalence;Prevention approach;Process;programs;psychosocial;receptor;receptor expression;Receptor Signaling;repetitive behavior;Reporting;Research Domain Criteria;response;Risk;Risk Factors;Role;sex;sexual dimorphism;Signal Transduction;social;Social Behavior;social cognition;social communication;social deficits;Social Development;Social Discrimination;Social Interaction;social structure;Societies;Stereotyping;Structural defect;Structure;Supplementation;System;Testing;Therapeutic;thyroid disruption;Thyroid Gland;Thyroid Hormones;Time;toxicant;Translating;Vasopressins;Xenobiotics

PROJECT_TITLE: Maternal Transfer of Oxytocin and Thyroid-disrupting Indoor Flame Retardants Affecting Offspring Social Brain


ADMINISTERING_IC: DC

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_NAME: MONELL CHEMICAL SENSES CENTER

PHR: Project Narrative The Monell Chemical Senses Center is a multidisciplinary research institute devoted to improving health and well-being by advancing the scientific understanding of taste, smell, and related senses. Monell’s Postdoctoral Training Program provides interdisciplinary training for postdocs coming from a range of scientific disciplines, and we have trained 12 scientists under our T32 Institutional NRSA during the preceding funding period (4 of whom are still in training and 8 of whom have obtained individual postdoctoral funding or finished their training and taken on positions in the biomedical research workforce). We provide the tools for young scientists to gain independence—a high-yield scientific environment, committed faculty, and coursework in a range of biomedical research areas, including the responsible conduct of research—and we have adapted training to conduct science safely during the current pandemic.

PI_NAMEs: DALTON, PAMELA HELEN;MAINLAND, JOEL D (contact);REED, DANIELLE RENEE

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Chemicals;Training

PROJECT_TITLE: Interdisciplinary Training in the Chemical Senses


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Clinical Research;Coronaviruses;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because it focuses on the design, implementation, and evaluation of a computer-aided real-time approach for detecting PPE nonadherence in high-acuity medical settings. This system will facilitate monitoring of PPE adherence by healthcare workers in settings at high-risk for infection transmission and will form the foundation for developing alerting approaches to PPE nonadherence. The results of this research are expected to have an important positive impact on the protection of healthcare workers and their patients.

PI_NAMEs: BURD, RANDALL S. (contact);LINGURARU, MARIUS GEORGE ;MARSIC, IVAN ;SARCEVIC, ALEKSANDRA

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Accident and Emergency department;Address;Adherence;Adopted;Aerosols;Area;Categories;Centers for Disease Control and Prevention (U.S.);Cessation of life;clinical practice;Cognitive;Complex;Computer Assisted;computer human interaction;Computer Vision Systems;Computers;COVID-19;COVID-19 pandemic;COVID-19 risk;current pandemic;Data;deep learning model;design;Detection;Development;Engineering;Ensure;Equipment;Evaluation;Exposure to;Feedback;Foundations;Future;General Population;Goals;Guidelines;Health Personnel;Health protection;high risk;Hospitals;Human;human centered design;human-in-the-loop;improved;Incidence;Individual;Industrialization;Infection;infection risk;innovation;Intensive Care Units;lonely individuals;Machine Learning;machine learning method;Masks;Medical;Methods;Monitor;multidisciplinary;Operating Rooms;pandemic disease;Patients;Patients' Rooms;Performance;personal protective equipment;Physicians;Procedures;Public Health;Recommendation;Research;Research Personnel;Resources;Resuscitation;Risk Reduction;Safety;SARS-CoV-2 infection;simulation;System;Testing;Time;Training;transmission process;Video Recording;viral transmission;Virus Diseases;Visual;ward;Work;Workload;Workplace

PROJECT_TITLE: Development of a Video-based Personal Protective Equipment Monitoring System

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: OMAHA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PHR: NARRATIVE The Lyme disease spirochete Borrelia burgdorferi uses a small repertoire of gene regulatory proteins including the DnaK suppressor protein (DksA) to coordinate the expression of virulence genes required for the successful completion of its infectious cycle. This proposal is focused on characterizing how DksA senses tick-borne oxidants to direct B. burgdorferi virulence gene expression required for transmission by its tick vector Ixodes scapularis to mammalian hosts. With over 476,000 cases of Lyme disease each year, determining the molecular mechanisms underlying the ability of B. burgdorferi to complete its infectious cycle will enable the development of public health strategies to limit B. burgdorferi infections by disrupting the natural cycle of infection.

PI_NAMEs: BOURRET, TRAVIS J (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Antioxidants;Area;Binding;Biology;Black-legged Tick;Borrelia burgdorferi;combat;Coupled;Cysteine;Data;Development;Diagnosis;DNA-Directed RNA Polymerase;Environment;environmental stressor;enzootic;Etiology;Exposure to;Future;Gene Expression;Gene Expression Regulation;Genes;genetic manipulation;genetic regulatory protein;Genetic Transcription;genetic variant;Goals;In Vitro;Infection;innovation;insight;Ixodes;Knowledge;Label;Laboratories;Lyme Disease;Maps;Metabolism;Modeling;Modification;Molecular;Molecular Genetics;Monitor;Mus;Mutation;Nitric Oxide;Nitrogen Dioxide;novel;Nutrient;Nutrient availability;Order Spirochaetales;Osmolar Concentration;Osmosis;Oxidants;oxidation;Oxidation-Reduction;Pathogenesis;Positioning Attribute;Prevalence;prevent;Protein Array;Proteins;Proteomics;Public Health;Publishing;Reactive Nitrogen Species;Reactive Oxygen Species;Regulation;Regulator Genes;Research;response;Role;sensor;Site;Source;Stress;Sulfhydryl Compounds;System;Temperature;Testing;tick-borne;Tick-Borne Diseases;Tick-Borne Infections;Ticks;tool;transmission process;United States;vector;vector tick;vector-borne pathogen;virtual;virulence gene;Work;Zinc;Zinc Fingers

PROJECT_TITLE: Redox Regulation of DksA-dependent Borrelia burgdorferi infectivity

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Pediatric

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE Genetic research into attention deficit hyperactivity disorder (ADHD) lags in terms of: (1) sample size, (2) ancestral diversity, and (3) consideration of phenotypic heterogeneity. The Akili project will address all three of these critical gaps, phenotypically and genetically characterizing 4,000 children with ADHD and 2,000 age- and ancestry-matched controls in Kenya and South Africa. All data and materials from Akili will be made publicly available through the NIMH, creating a research resource of international value.

PI_NAMEs: ROBINSON, ELISE B (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Acceleration;Address;Africa;African;Age;Architecture;Area;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;Award;Behavioral;Biological;Caring;case control;Child;Clinical;clinically relevant;Cognitive;cohort;Collection;Data;Data Collection;design;Development;Diagnosis;diagnostic criteria;Disease;DNA;doctoral student;Education;Enrollment;Ensure;Equity;European ancestry;executive function;exome;exome sequencing;Fruit;Funding;gene discovery;Generalized Anxiety Disorder;Genes;Genetic;genetic architecture;Genetic Research;Genetic Risk;Genetic study;genome wide association study;genome-wide;Genomics;Genotype;Goals;Health;Heterogeneity;Hyperactivity;improved;Impulsivity;insight;Intellectual functioning disability;International;Interview;Kenya;Lead;Leadership;Link;Maps;Medical;Medical History;member;Mind;Mood Disorders;National Institute of Mental Health;Neurodevelopmental Disorder;neuropsychiatric disorder;neuropsychiatry;non-verbal;Occupational;Outcome;Parents;Participant;Phenotype;phenotypic data;polygenic risk score;Population;psychiatric genomics;rare variant;Raven;recruit;Research;Resources;risk sharing;risk variant;Saliva;Sample Size;Sampling;Schedule;School-Age Population;Scientist;Severities;sex;Site;skills;social;South Africa;South African;Speed;Students;success;Sustainable Development;tool;Training;trait;United States;Variant;Work

PROJECT_TITLE: 1/3 Akili: Phenotypic and genetic characterization of ADHD in Kenya and South Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-Z(60)C]


ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The Medical Scientist Training Program at the University of Miami Miller School of Medicine seeks to develop diverse, highly motivated physician scientists who will pursue careers matching state of the art research with evidence-based medicine. The program is tailored to generate clinician investigators with training in experimental biomedical sciences, biomedical engineering, computational approaches, or public health sciences, who will be instrumental in generating and translating research findings into clinical practice while transforming healthcare policies. By providing high quality training in rigorous research and clinical practice, as well as professional development, our trainees will be positioned to develop innovative approaches for the prevention and treatment of disease.

PI_NAMEs: FORNONI, ALESSIA ;LIEBL, DANIEL JON (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: MADISON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The Center for Demography and Ecology at the University of Wisconsin-Madison offers outstanding and innovative training in demographic research, focused on the areas of fertility and families, inequality, health and the lifecourse, biodemography, and spatial and environmental demography. Our trainees pursue research careers across academic, government, and applied research settings. Their research increases our understanding of the behavioral, social, and economic processes that shape the health and wellbeing of the American population.

PI_NAMEs: CURTIS, KATHERINE J. (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Demography;Ecology

PROJECT_TITLE: Demography and Ecology


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: NARRATIVE Roseoloviruses cause common childhood infections and have been suggested to play a role in autoimmune disease, but demonstrating a causative role has been difficult due to the high prevalence and chronic nature of human roseolovirus infections. We have discovered that murine roseolovirus (MRV), which is highly related to human roseoloviruses, causes autoimmune disease after neonatal infection due to its effects on immunologic tolerance, the process of removing self-reactive T cells during development in the thymus. In this proposal, we will identify the mechanism by which MRV causes autoimmunity and compare MRV infection to human roseolovirus infection, providing new insight into how roseolovirus could cause autoimmune disease in humans.

PI_NAMEs: BIGLEY, TARIN M (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: acute infection;Address;Adult;Age;Antigens;Atrophic;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;autoimmune gastritis;Autoimmunity;autoreactive T cell;autoreactivity;Award;Biological Assay;Bystander Effect;career;career development;CD4 Positive T Lymphocytes;Cell Count;Cell Culture Techniques;Cell Physiology;central tolerance;Childhood;Chronic;Clinical;Comparative Study;Data;Development;Etiology;Exanthema;Exanthema Subitum;experimental study;Fever;Flow Cytometry;Funding;Future;Gastric Parietal Cells;Gene Expression;Genes;Goals;Herpesviridae;High Prevalence;Human;Human Characteristics;Human Herpesvirus 6;Human Herpesvirus 7;Immune system;Immune Tolerance;Immunology;In Vitro;in vivo;Infection;Inflammation;insight;K ATPase;K-Series Research Career Programs;Kinetics;Knowledge;Laboratories;latent infection;Life;Link;Mediating;Mentors;Modeling;Molecular Mimicry;Mouse Strains;Mus;Nature;Neonatal;neonatal infection;novel;Organ;pathogen;Periodicals;Peripheral;Persons;Physicians;Process;Production;Proteins;Regulatory T-Lymphocyte;Research;Research Project Grants;Resolution;Rheumatology;Role;Roseolovirus;Roseolovirus Infections;Scientist;Seroprevalences;single-cell RNA sequencing;Sorting;Stomach;T cell receptor repertoire sequencing;T-Cell Depletion;T-Cell Development;T-cell receptor repertoire;T-Lymphocyte;Thymic epithelial cell;thymocyte;Thymus Gland;Time;time use;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Viral;Virus;Virus Diseases;Virus Replication;Wild Type Mouse

PROJECT_TITLE: Establishing the impact of roseolovirues on development of autoimmunity due to loss of central tolerance

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Congenital Structural Anomalies;Genetics;Hydrocephalus;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Proliferative Vasculopathy and Hydranencephaly Hydrocephalus (PVHH) is a genetic form of congenital hydrocephalus caused by mutation in the heme transporter, Flvcr2. In this proposal, we investigate how heme, a molecule important for carrying oxygen in the body, is involved in the pathogenesis of PVHH.

PI_NAMEs: ARNOLD, THOMAS DARMODY (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Affect;Alleles;angiogenesis;bevacizumab;Biological Assay;Birth;Blood Vessels;Brain;brain abnormalities;brain endothelial cell;Cell Differentiation process;Cell Proliferation;Cells;cerebral vascularization;Cerebrospinal Fluid;Cerebrovascular system;Clinical;cofactor;Complex;conditional knockout;Congenital Hydrocephalus;Data;Development;Disease;DNA Sequence Alteration;Endothelial Cells;Endothelium;Environmental Risk Factor;Etiology;Gene Deletion;Genes;Genetic;genetic approach;Genetic Transcription;Goals;Growth;Heme;Hemeproteins;HIF1A gene;Human;Human Genetics;Hydranencephaly;Hydrocephalus;Hypoxia;Hypoxia Inducible Factor;Immunohistochemistry;In Vitro;in vivo;innovation;Knowledge;Link;LoxP-flanked allele;Measures;Metabolism;Modeling;mouse model;Movement;Mus;Mutant Strains Mice;Mutation;nerve stem cell;Neurologic;Neurons;notch protein;Nutrient;Online Mendelian Inheritance In Man;Oxygen;oxygen transport;Pathogenesis;Pathology;Pathway interactions;pharmacologic;Pharmacological Treatment;Phenotype;Process;Protein Dynamics;Proteins;Proteomics;Reporter;Research;Role;Secondary to;Signal Transduction;Source;Starvation;Syndrome;Techniques;Testing;Tissues;trafficking;Up-Regulation;Vascular Diseases;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Vascular Endothelium;Work

PROJECT_TITLE: Defective heme transport in the development of congenital hydrocephalus

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Pediatric;Prevention;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The Paramyxoviridae family includes several pathogenic viruses that pose major threats to human health, including human parainfluenza virus 3 (HPIV3) which causes illness or death in millions of infants and young children, and the lethal Nipah (NiV) and Hendra (HeV) viruses that pose a risk of global emergence. We propose to apply the results of our fundamental research to advance a potent new antiviral strategy that is based on the use of fusion-inhibitory peptides to block viral entry.

PI_NAMEs: MOSCONA, ANNE  (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Accidents;acute toxicity;African Green Monkey;Amino Acids;Animal Model;Animals;Anti-viral Agents;anti-viral efficacy;Anti-viral resistance;Antibodies;appendage;base;Binding Proteins;Biodistribution;Biological Assay;Brain;Bronchiolitis;Cell membrane;Cells;Cessation of life;Child;Childhood;Chimeric Proteins;Clinical;combat;Complex;conformational conversion;Cotton Rats;Croup;design;Drug Kinetics;efficacy evaluation;efficacy study;Ensure;env Gene Products;Evolution;experimental study;Family;Finding by Cause;fundamental research;Glycoproteins;Goals;Half-Life;Health;Hemagglutinin;Hendra;Hendra Virus;Henipavirus;Human;human disease;immunogenicity;improved;In Vitro;in vivo;Infant;Infection;Inhalation;Inhalation Drug Administration;inhibitor;innovation;Interruption;Lead;lead candidate;Lipids;Lung;Mediating;Membrane;Membrane Fusion;Mesocricetus auratus;Methods;Modeling;Modification;Molecular;Molecular Conformation;Mutation;Neuraminidase;Nipah Virus;Nose;novel;Organoids;Para-Influenza Virus Type 3;parainfluenza virus;Paramyxovirus;passive immunoprophylaxis;pathogenic virus;Peptide Hydrolases;Peptides;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pneumonia;Positioning Attribute;Preparation;prevent;Property;prophylactic;protein aminoacid sequence;Proteins;prototype;receptor binding;Receptor-Interacting Protein;Resistance;Resistance development;resistance mechanism;respiratory virus;Risk;Rodent;Self Administration;Series;Site;Structure;Structure of parenchyma of lung;System;Therapeutic;Tissue Model;Tissues;transmission process;vaccine access;Validation;Vertebral column;Viral;viral entry inhibitor;Viral Physiology;viral resistance;Virus

PROJECT_TITLE: Broad spectrum inhibitors of paramyxovirus envelope proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(82)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: DAVIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Identifying environmental factors related to Alzheimer's disease and related dementia (ADRD) risk is critical to reducing the burden of ADRD and is recommended by the 2018 National Institute on Aging AD Research Summit recommended. We propose to link geocoded residential history from a large diverse sample with newly collected data on (1) extreme weather events, (2) ambient particulate air pollution, and (3) toxic environmental contaminant exposures, to identify environmental exposures linked to ADRD, examine how these exposures are distributed across different racial/ethnic groups and across the lifecourse, and identify timing in the lifecourse during which these exposures are especially salient to ADRD and late-life cognition. Findings from the study may provide targets of ADRD intervention that would improve healthy brain aging for people of all racial/ethnic groups.

PI_NAMEs: CONLON, KATHRYN C (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Acceleration;Address;advanced disease;Affect;African American population;Age;Aging;aging brain;Air;Air Pollution;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Amyloid;behavior measurement;Birth;Brain;California;Cardiovascular Diseases;cardiovascular risk factor;Chemicals;climate change;clinical examination;Cognition;Cognitive;cognitive function;cohort;Cohort Studies;Computerized Medical Record;Data;Dementia;dementia risk;Development;Diameter;disorder prevention;Disparity;Droughts;Environment;environmental chemical;Environmental Exposure;Environmental Pollutants;Environmental Risk Factor;Ethnic Origin;Ethnic Population;Etiology;Event;Exposure to;extreme heat;extreme weather;fine particles;Frequencies;Funding;Goals;health data;healthy aging;imaging biomarker;Impaired cognition;improved;Incidence;Individual;Intervention;late life;Lead;Life;Life Cycle Stages;Life Experience;life span;Link;Literature;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;Mercury;meter;Methodology;Modernization;modifiable risk;multidimensional data;National Institute on Aging;Neurocognitive;neuroimaging;neuroimaging marker;Neuropsychological Tests;Neurotoxins;Older Population;Outcome;Particulate;Particulate Matter;Pattern;Persons;Population;Population Heterogeneity;Positron-Emission Tomography;Precision Health;prevent;Prevention;psychosocial;Public Health;Race;racial population;Recommendation;Recording of previous events;Research;Risk;Risk Factors;Role;Sampling;Severities;Strategic Planning;Stroke;study population;symposium;Temperature;Testing;Time;trend;Ultrafine;ultrafine particle;United States National Institutes of Health;Wildfire

PROJECT_TITLE: Extreme weather-related events and environmental exposures in the risk for Alzheimer's disease and related dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(90)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Trichomonasviruses infect the parasite T. vaginalis, which in turn infects the human urogenital tract. We intend to study the mechanisms of how the parasite and virus coexist, and how viral infection virus may benefit the parasite and worsen the human disease.

PI_NAMEs: HETZEL, CARRIE ANN (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Adherence;Biological Models;Candidate Disease Gene;Cells;Cervical;Clinical;Coculture Techniques;Daughter;differential expression;Disease Progression;Double Stranded RNA Virus;Double-Stranded RNA;Epithelial Cells;Exonuclease;experimental study;extracellular;fitness;Gene Expression;Genes;Genetic;helicase;High-Throughput RNA Sequencing;Human;human disease;human pathogen;Infection;Inflammation;Inflammatory;Inflammatory Response;Interferons;IRF3 gene;Life Cycle Stages;Longitudinal Studies;Malignant neoplasm of prostate;Measures;Mediating;Morphology;Mothers;NF-kappa B;nucleoside analog;Parasites;Parents;Pathway interactions;Pelvis;Predisposition;Premature Birth;Proliferating;Proteins;Reporting;response;RNA;RNA Viruses;RNA-Binding Proteins;Role;Severity of illness;Sexually Transmitted Diseases;Testing;Tissue-Specific Gene Expression;TLR3 gene;transcriptome sequencing;transmission process;Trichomonas Infections;Trichomonas vaginalis;urogenital tract;Vagina;Viral;Virion;Virulence;Virus;Virus Diseases;virus host interaction;Virus Replication;Work

PROJECT_TITLE: Interactions between trichomonasviruses, their parasite host, and the human superhost


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: GENETICALLY-ENGINEERED PIG ORGAN TRANSPLANTATION IN BABOONS: IMMUNOLOGICAL AND FUNCTIONAL STUDIES (PI/PD: David K.C. Cooper) OVERVIEW OF THE PROGRAM PROJECT NARRATIVE  The research outlined in this application is directed to transplanting organs (kidneys, livers, hearts) from specifically-genetically-engineered pigs into baboons receiving potent immunosuppressive therapy to demonstrate that xenotransplantation would be successful in patients with terminal organ failure. The pigs will be genetically-engineered to (i) no longer express the two known target antigens against which baboons have natural antibodies, and (ii) express human transgenes that further protect the pig organ from the primate’s immune response. The function of these transplanted pig organs will be intensively monitored to ensure that they are likely to be life-supporting in a human recipient.

PI_NAMEs: COOPER, DAVID KC (contact)

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: adaptive immune response;allotransplant;Antigen Targeting;clinical application;Clinical Trials;Destinations;Doctor of Philosophy;Endothelial Cells;Family suidae;Fat emulsion;Funding;Genes;Genetic;Genetic Engineering;genetic manipulation;Goals;graft failure;Graft Survival;Growth Hormone Receptor;Heart;heart function;Heart Transplantation;Histopathology;Human;Immune response;Immunobiology;Immunologics;Immunology procedure;improved;Infusion procedures;Innate Immune Response;Intervention;Kidney;Kupffer Cells;Life;Liver;liver function;liver transplantation;Methods;Mitochondria;Modeling;Modification;Monitor;Myocardium;natural antibodies;nonhuman primate;novel;Organ;Organ failure;organ growth;organ injury;Organ Transplantation;organizational structure;Papio;Patients;Phagocytosis Inhibition;pharmacologic;Preservation Technique;prevent;Primates;Procedures;programs;rapid growth;Regimen;Renal function;Research;Science;Source;success;Techniques;Therapeutic;Therapeutic immunosuppression;Thrombocytopenia;Transgenes;Transplantation;Triiodothyronine;Work;Xenograft procedure

PROJECT_TITLE: Genetically-engineered pig organ transplantation in baboons: immunological and functional studies


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Liver Disease;Organ Transplantation;Transplantation

PROJECT_TERMS: Communication;Coordination and Collaboration;data sharing;Family suidae;Funding;Genetic Engineering;Goals;Heart Transplantation;Histopathology;Human Resources;Immunologics;Immunology procedure;Kidney Transplantation;Laboratories;Lead;liver transplantation;Logistics;Maintenance;member;National Institute of Allergy and Infectious Disease;Organ Transplantation;organizational structure;Papio;Participant;Play;Preparation;programs;Publications;Research Personnel;Shipping;success;Travel

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: TROY

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

PHR: Project Narrative Cell-cell junctions are tightly controlled during physiological activities. Vascular disorders change the leakiness of blood vessels drastically, leading to severe consequences including death. Here we propose to study the biophysical mechanism of cell handedness in the maintenance of vascular integrity.

PI_NAMEs: WAN, LEO Q. (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: 3-Dimensional;Actins;Acute Disease;Acute Lung Injury;Address;Adherens Junction;adherent junction;Affect;Animal Model;Biological;Biological Process;Biomechanics;biophysical analysis;Biophysical Process;Blood Circulation;Blood Vessels;cadherin 5;cell type;Cells;Cessation of life;Chronic;crosslink;Crosslinker;Cytoskeleton;Data;Development;Diabetes Mellitus;Embryonic Development;Endothelial Cells;endothelial dysfunction;Endothelium;Engineering;Environment;Epithelium;fascin;Future;Handedness;Hydrogels;In Vitro;Intercellular Junctions;interstitial;invention;Left;Location;Maintenance;mechanical force;Mechanics;Mediating;Modeling;Molecular;Morphogenesis;novel;Organism;organizational structure;Patients;Pattern;Permeability;Physiological;Physiology;Process;Property;Protein Isoforms;Protein Kinase C;Proteins;Regulation;Research;Role;screening;Sepsis;Signal Transduction;Smoking;Structure;Substrate Interaction;System;Tight Junctions;Tissues;Traction Force Microscopy;Vascular Diseases;Vascular Permeabilities;Virus Diseases

PROJECT_TITLE: Understanding Chirality at Cell-Cell Junctions With Microscale Platforms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(80)S]


NIH_SPENDING_CATS: Biotechnology;Immunotherapy;Kidney Disease;Organ Transplantation;Regenerative Medicine;Transplantation

PROJECT_TERMS: adaptive immune response;Attention;Chronic;Dialysis procedure;End stage renal failure;Family suidae;Genes;Genetic Engineering;genetic manipulation;graft function;Immune;Immune response;Immunologic Monitoring;Immunologics;improved;Injury;Innate Immune Response;Kidney;Kidney Transplantation;Knowledge;Lead;Life;Measures;nonhuman primate;novel;Organ;Organ Transplantation;Papio;Pathway interactions;Patients;Physiological;Primates;programmed cell death ligand 1;Regimen;Renal function;Testing;Therapeutic immunosuppression;TNFRSF5 gene;TNFSF5 gene;transgene expression;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Genetically-engineered pig kidney transplantation in baboons: reducing the adaptive immune response and monitoring graft function


PI_NAMEs: MOHIUDDIN, MUHAMMAD M (contact)

PROJECT_TERMS: adaptive immune response;Cardiac;Circulation;Clinical Trials;Complex;Ensure;experimental study;Family suidae;follow-up;Functional disorder;Genes;Genetic Engineering;genetic manipulation;Goals;graft failure;graft function;Graft Survival;Growth;Growth Hormone Receptor;Heart;Heart failure;heart function;heart preservation;Heart Transplantation;heart xenograft;hemodynamics;Immune response;Immunologics;immunosuppressed;Impairment;Innate Immune Response;Investigation;Knock-out;Knowledge;Laboratories;Left Ventricular Hypertrophy;Life;Light;Measures;Mitochondria;mitochondrial dysfunction;Myocardial;nonhuman primate;novel;Organ;organ growth;Organ Transplantation;Outcome;Papio;Perioperative;preservation;prevent;Primates;rapid growth;Receptor Gene;Regimen;Reporting;Source;success;System;Testing;Therapeutic;Transplantation;Triiodothyronine;Xenograft procedure

PROJECT_TITLE: Genetically-engineered pig orthotopic (life-supporting) heart transplantation (OHTx) in baboons: establishing consistent graft survival and overcoming rapid post-Tx organ growth


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Huntington’s Disease is an inherited, fatal disease with no cure or effective treatment. We will explore how the mutation causing the disease affects different types of cells in the brain. We will combine these data with information about genes that either slow or accelerate the age when patients develop symptoms to uncover new approaches to treating the disease.

PI_NAMEs: FRAENKEL, ERNEST  (contact);HOUSMAN, DAVID

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Affect;age acceleration;Age of Onset;Alleles;Animal Model;BETA2 protein;Biological Assay;Biological Models;Brain;Brain region;Cell Culture Techniques;Cell Differentiation process;Cell model;Cell Nucleus;cell type;Cells;Chromatin;Corpus striatum structure;Data;data integration;Disease;disease model;effective therapy;ELK1 gene;Energy Metabolism;Epigenetic Process;epigenome;epigenomics;gene therapy;Genes;Genetic;Genetic Transcription;genetic variant;Genomics;Goals;Grant;group intervention;Human;human induced pluripotent stem cells;Huntington Disease;Huntington gene;improved;In Vitro;in vivo;in vivo evaluation;Individual;induced pluripotent stem cell;Inherited;innovation;insight;Intervention;Investigation;Link;Lipid Biochemistry;Lipids;Literature;Measures;metabolomics;Methods;Modeling;Molecular;Multiomic Data;Mus;mutant;Mutate;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurodevelopmental Impairment;novel strategies;novel therapeutic intervention;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Phosphotransferases;Population;programs;Prostaglandin D2;Proteins;Proteomics;Research;Resolution;response;Signal Transduction;single cell ATAC-seq;stem cell model;Symptoms;System;Systems Biology;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Transcript;transcriptome sequencing;Variant;Work

PROJECT_TITLE: Epigenetic Pathology and Therapy in Huntington's Disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Physical Activity;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: LOWELL

ORG_NAME: UNIVERSITY OF MASSACHUSETTS LOWELL

PHR: Project Narrative  Prevention of fall injuries is a national public health priority. This study investigates the rural-urban, gender and racial/ethnic differences in time and space use in relation to falls among older adults. Personalized risk prediction models for location- and activity-specific falls will be created to support community-based programs that are effective across the rural-urban continuum, in both genders and among racial/ethnic groups for promoting active aging and preventing falls.

PI_NAMEs: LI, WENJUN  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: 3-Dimensional;Accelerometer;active lifestyle;Address;Adult;Age;Aging;Area;Asian population;Automobile Driving;Behavioral;Black Populations;Calendar;cohort;Communities;community based research;Data;data integration;density;design;Development;Devices;disability;Elderly;Environment;Epidemiology;ethnic difference;ethnic disparity;ethnic diversity;ethnic minority;Ethnic Population;Event;Exercise;Exposure to;fall injury;Fall prevention;fall risk;falls;Fitness Centers;follow-up;Formulation;Frequencies;Gender;gender difference;gender disparity;Global Positioning System;Goals;Habits;hazard;Health;Health behavior;Health Status;Hispanic Populations;Home visitation;Housing;human old age (65+);Individual;Injury;innovation;Interview;Knowledge;Life Style;Living Arrangement;Location;Longitudinal cohort;Massachusetts;Measures;Medicaid;Medical Care Costs;Medicare;men;Methodology;Neighborhoods;Not Hispanic or Latino;novel;older adult;older men;Participant;Pattern;payment;Perception;Personal Attribute;personalized predictions;personalized risk prediction;personalized strategies;Persons;Physical activity;Physical Function;Population;Population Density;Predictive Factor;predictive modeling;Prevention approach;programs;public health priorities;Race;racial difference;racial disparity;racial diversity;racial minority;racial population;randomized, clinical trials;Recreation;Reporting;Research;Resources;Risk;Risk Factors;risk prediction model;Rural;rural area;rural disparities;rural dwellers;Socioeconomic Status;socioeconomics;suburb;Surveys;Telephone;Testing;Time;time use;urban area;urban disparity;urban setting;Walking;Woman

PROJECT_TITLE: Neighborhood Risk Factors for Falls in the Elderly

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-J(04)R]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Better understanding of causative mechanisms in autism spectrum disorder (ASD) is urgently needed to inform treatment for more than 1% of children worldwide who are affected with ASD. This research identifies mutations in the neuronal BAF chromatin remodeling subunit ACTL6B as a highly penetrant cause of recessive autism and validates Actl6b knockout mice as a model. Building on these findings, the goals of the project are to uncover molecular and circuit mechanisms that cause autism-related phenotypes in Actl6b-/- mice.

PI_NAMEs: WENDERSKI, WENDY  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Action Potentials;ACTL6B gene;Affect;Agonist;Alleles;Anatomy;Animal Model;Animals;ATAC-seq;autism spectrum disorder;autistic behaviour;Behavior;Behavior Control;behavior influence;Biological Assay;Biology;Brain;brain circuitry;BRAIN initiative;cell type;Child;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Cleavage Under Targets and Release Using Nuclease;Collaborations;Complex;Data;derepression;Development;Disease;DNA Sequence Alteration;Doctor of Philosophy;empowerment;Epigenetic Process;ERG gene;Etiology;Exhibits;experimental study;Family;Future;Gene Activation;Gene Silencing;Genes;Genetic;genetic regulatory protein;Genetic Transcription;Genome;Genomics;Goals;Heritability;Histone Acetylation;histone modification;Human;Impairment;impression;Inherited;insight;Investigation;Knockout Mice;Laboratories;Learning;Link;Malignant Neoplasms;Memory;Mentors;Mission;model of autism spectrum disorder;Modeling;Molecular;mouse model;Mus;mutant;Mutate;Mutation;NCOR1 gene;neural;neural circuit;neurodevelopment;Neurodevelopmental Disorder;neuron loss;neuronal circuitry;Neuronal Plasticity;Neurons;Neurosciences;new therapeutic target;Nuclear Extract;Nucleosomes;Pathway interactions;Phase;Phenotype;Population Control;post-doctoral training;Postdoctoral Fellow;Repression;Research;Research Assistant;Research Project Grants;Research Support;response;Rest;Risk;Role;Seminal;Serotonin Receptor 5-HT1B;Site;skills;social;Social Behavior;social communication impairment;Social Responsibility;Synaptic plasticity;System;Testing;Tissues;tool;Training;transcription factor;Transcription Factor AP-1;transcriptome sequencing;Treatment Efficacy;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Discovery of a cerebellar-specific BAF chromatin remodeler that is necessary for social inhibition: molecular and circuit mechanisms


ORG_CITY: NAIROBI

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: AGA KHAN UNIVERSITY (KENYA)

PI_NAMEs: ALI, AMINA ABUBAKAR (contact)

PROJECT_TITLE: 2/3 Akili: Phenotypic and genetic characterization of ADHD in Kenya and South Africa