ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Macular Degeneration;Nanotechnology;Neurodegenerative;Neurosciences

ORG_CITY: WASHINGTON

ORG_NAME: MOBIUS SCIENTIFIC INC.

ORG_STATE: DC

PHR: Project Narrative This proposal examines a novel approach to cholesterol removalthrough use of proprietary nanodiscs in the eye to treat dry age-related macular degeneration, the leading cause of blindness among people over age 50 years in the United States. The approach will first systematically generate the optimal nanodisc for cholesterol removal and then test efficacy in relevant cellular and pre-clinical models. Led by experts in lipids, eye disease, and nanodiscs, completion of these studies will validate cholesterol removal as a treatment strategy for dry age- related macular degeneration.

PI_NAMEs: MEHTA, NEHAL N (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Age;Age related macular degeneration;angiogenesis;ATP binding cassette transporter 1;Atrophic;Automobile Driving;Basement membrane;Biological Assay;Biology;biophysical analysis;biophysical properties;Blindness;Bruch's basal membrane structure;Cell Culture Techniques;Cell Death;Cell model;Cells;Cholesterol;Choroidal Neovascularization;Data;Deposition;design;Developed Countries;Development;Diameter;Disease;Disease Progression;Drusen;efficacy testing;Elderly;Excision;Eye;Eye diseases;Fatty Acids;Foundations;Generations;geographic atrophy;Goals;Good Manufacturing Process;Head;High Density Lipoproteins;High Fat Diet;Homeostasis;Human;Human Engineering;in vivo evaluation;intravitreal injection;invention;Knockout Mice;Laboratories;Life;Lipid Bilayers;lipid transport;Lipids;Lipoproteins;Macrophage;Membrane;Membrane Proteins;mouse model;nanodisc technology;nanodisk;nanolipoprotein particles;Nerve Degeneration;neurosensory;Nonexudative age-related macular degeneration;novel;novel strategies;particle;Pathogenicity;Pathway interactions;Persons;pharmacokinetics and pharmacodynamics;Phase;Pre-Clinical Model;Prevention;Process;Production;Protein Engineering;Proteins;prototype;receptor;Retina;reverse cholesterol transport;Rod;Role;Scaffolding Protein;Structure of retinal pigment epithelium;Surface;targeted treatment;Testing;Therapeutic;Time;Tissues;Toxic effect;treatment strategy;United States;uptake;Vertebral column;Visual impairment;Work

PROJECT_TITLE: Cholesterol Removal as a  Treatment for Dry Age-Related Macular Degeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-M (12)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Genetics;Skin Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative In the normal epidermis, ultraviolet radiation exposure induces the protective tanning response which transiently upregulates keratinocyte to melanocyte crosstalk. Melanoma cells hijack the protective tanning response, forcing keratinocytes to release factors that enrich for or stimulate the emergence of stem-like properties in melanoma cells. This project will investigate the mechanism by which melanoma cells activate pro- melanomagenic signaling in keratinocytes and the extent to which that signaling enhances melanoma migration, invasion and drug resistance.

PI_NAMEs: POKORNY, JENNY  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: acquired drug resistance;Acute;Address;Adopted;Adoption;Benign;Biological Assay;BRAF gene;Cadherins;cell motility;Cell-Cell Adhesion;Cells;chemokine;Chronic;Clinical;Communication;CXCL1 gene;cytokine;Data;desmoglein 1;Desmosomes;Down-Regulation;Drug resistance;EGF gene;Environment;Epidermis;Exhibits;experimental study;Exposure to;Family;Family member;FGF2 gene;Gene Expression Profile;Gene Modified;genetic manipulation;Genetic Transcription;Goals;Growth Factor;Human;human tissue;IL8RB gene;In Situ;in vivo;Inflammatory;inhibitor;Invaded;keratinocyte;Lead;Lesion;MAP Kinase Gene;Mass Spectrum Analysis;Mediating;Mediator;MEKs;Melanins;melanocyte;Melanoma;Melanoma Cell;Melanoma patient;member;migration;Molecular;neural;Neural Crest;Nevi and Melanomas;novel;paracrine;Paracrine Communication;Pathway interactions;Phenotype;Platelet-Derived Growth Factor;Population;Production;programs;Property;release factor;Reporting;response;RNA;Role;Signal Transduction;single molecule;Skin tanning;slug;Source;Specimen;Stains;stem;stemness;Tissues;Transcription Coactivator;Transcription Repressor;transcriptome sequencing;tumorigenic;Ultraviolet Rays;UV Radiation Exposure;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Paracrine signaling from keratinocytes establishes a pro-melanoma environment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-Z (20)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Celiac Disease;Digestive Diseases;Genetics;Infectious Diseases;Nutrition;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Gastrointestinal disorders, such as celiac disease, are a significant global health challenge due to their dramatically increasing prevalence in the general USA population resulting in excessive health care costs. In this study, a non-pathogenic gut protist is used as a method to increase oral tolerance to gluten, hence reducing the negative inflammatory reactions that lead to the onset of celiac disease. This novel concept aims to benefit human health as the identified protist-immune regulatory mechanisms are likely to provide new protist-based therapeutic interventions to prevent and revert celiac disease.

PI_NAMEs: MEDINA-SANCHEZ, LUZMARIEL  (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Alleles;Antigen Presentation;Antigens;Barley;Celiac Disease;Cell Culture Techniques;Coculture Techniques;comparison control;cytokine;Data;Dendritic Cells;Development;dietary;Digestive System Disorders;Disease;disease model;Down-Regulation;Economic Burden;enteric infection;enteric virus infection;Environment;Environmental Risk Factor;experimental study;Exposure to;Food;food antigen;Fostering;Gastrointestinal Diseases;General Population;Genes;Genetic;Genetic Transcription;global health;Gluten;Gluten-free diet;Goals;gut microbes;gut microbiome;Health;Health Care Costs;Healthcare;High Prevalence;HLA Antigens;Homeostasis;Human;Immune;Immune response;Immunity;In Vitro;Individual;Infection;Inflammation;Inflammatory;Ingestion;innovation;insight;Integrins;Interleukin-10;Intestines;ITGAM gene;Lead;Link;Maintenance;Mediating;Methods;Microbe;microbial;Modernization;mouse model;Mucosal Immune System;Mus;Norovirus;novel;novel strategies;novel therapeutic intervention;oral tolerance;paralogous gene;pathogen;Pathogenesis;Pathologic Processes;Pathway interactions;Patients;Peripheral;Persons;Play;Population;preservation;Prevalence;prevent;Production;programs;Proteins;Quality of life;Reaction;Regulatory T-Lymphocyte;Reovirus;response;restraint;Risk;risk variant;Role;Rye cereal;Sampling;screening;Signal Transduction;standard of care;Stomach;stool sample;T cell differentiation;T-Lymphocyte;Testing;Therapeutic Intervention;Time;transcriptome sequencing;Treatment Protocols;Tritrichomonas;Virus;Wheat

PROJECT_TITLE: Role of Gut Protist Derived Compounds on Dietary Antigen Presenting Dendritic Cells in Celiac Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (O1)]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Cardiovascular;Congenital Structural Anomalies;Gene Therapy;Genetics;Heart Disease;Myasthenia Gravis;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: TOWSON

ORG_NAME: AMPLO BIOTECHNOLOGY, INC.

ORG_STATE: MD

PHR: NARRATIVE DoK-7 congenital myasthenic syndrome is an orphan rare neuromuscular disorder associated with limb-girdle pattern of weakness, choking spells, respiratory insufficiency, and severe scoliosis. AMP-101 is a gene therapy product with demonstrated efficacy in pre-clinical models of the disease and clean toxicology profile at 29 and 183 days which will be able to shift current clinical practice from chronic administration of drugs to alleviate symptoms to a one-off treatment, administered through a single intravenous injection. The project will complete AMP-101 development including GLP manufacturing and clinical assays to detect cellular immune responses against viral antigens and viral shedding ensuring smooth transition to the clinic.

PI_NAMEs: SEPULVEDA, PATRICIO  (contact)

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Acetylcholine;Acetylcholinesterase;Acetylcholinesterase Inhibitors;adeno-associated viral vector;Adrenergic Agonists;Adrenergic Receptor;Adult;Affect;Age;aged;Albuterol;Amyotrophic Lateral Sclerosis;assay development;beta-2 Adrenergic Receptors;Biological Assay;Biological Products;Biological Sciences;Biotechnology;Birth;Blood;Body Weight;Breathing;C57BL/6 Mouse;Cardiomyopathies;Child;Choking;Chronic;Clinic;Clinical;clinical assay development;clinical development;clinical practice;clinical trial protocol;Collaborations;Congenital Myasthenic Syndromes;curative treatments;Data;Defect;Dependence;design;Deterioration;Development;Disease;Disease Management;disease model;Disease Progression;DNA Sequence;Dose;Emery-Dreifuss Muscular Dystrophy;Ensure;Enteral Feeding;enzyme linked immunospot assay;Ephedrine;exercise intolerance;Exertion;Exposure to;extend lifespan;Feces;feeding;France;functional restoration;gene therapy;Genes;Germany;Goals;Growth;Hand Strength;Health;Health Personnel;Heart failure;Hepatotoxicity;Histopathology;Human;Hybrids;Immune response;improved;Inflammatory Response;Inherited;inhibitor;Interferons;intravenous injection;Japan;Knock-in Mouse;Left;Legal patent;Limb structure;Literature;manufacture;Modeling;Motor Activity;motor impairment;mouse model;Mus;Muscle Weakness;Mutation;Myasthenia;Myocardial Ischemia;Natural History;Natural regeneration;Neurology;Neuromuscular Diseases;Neuromuscular Junction;Neuromuscular Junction Diseases;Orphan;Patients;Pattern;Persons;Pharmaceutical Preparations;Pharmacology Study;Phase;Phase I Clinical Trials;Phenotype;Physicians;Plasma;Plasmids;polypeptide;Population;postnatal;Pre-Clinical Model;preclinical development;Price;Production;programs;Protein Tyrosine Kinase;Proteins;Publishing;Quality of life;Quality-Adjusted Life Years;Rare Diseases;Recombinant adeno-associated virus (rAAV);recruit;Recurrence;reduce symptoms;Refractory;respiratory;Respiratory Insufficiency;Running;Safety;safety study;Saliva;Sampling;scoliosis;Signal Transduction;Small Business Innovation Research Grant;Specific qualifier value;spelling;Spinal Muscular Atrophy;Standardization;Study Subject;symptom management;Synapses;Tachycardia;Technology;Testing;Tokyo;Toxicology;Tracheostomy procedure;transmission process;Universities;Urine;vector;Viral Antigens;Virus Shedding;Walking;Weight;Wheelchairs

PROJECT_TITLE: Targeted DOK7 gene therapy for Congenital Myasthenic Syndromes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-G (13)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Complementary and Integrative Health;Dementia;Depression;Mental Health;Natural Products;Neurodegenerative;Neurosciences;Nutrition;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BOSTON

ORG_NAME: SENSORIUM THERAPEUTICS INC

ORG_STATE: MA

PHR: PROJECT NARRATIVE Mild Cognitive Impairment, associated with memory loss and changes in cognitive function, is one of the earliest symptoms of Alzheimer’s Disease (MCI-AD). Botanical natural products (NPs) have shown to improve cognition in AD patients, however incomplete descriptions of molecular targets, mechanisms, and appropriate brain exposure have limited their development for MCI-AD. Sensorium Therapeutics is developing their Biodynamic Discovery Platform (BDP) to identify and develop psychoactive natural products to treat AD by delaying MCI onset after the earliest signals of pathology can be detected.

PI_NAMEs: BROWN, JEFFREY M. (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: ABCB1 gene;Acetylcholinesterase Inhibitors;adverse event risk;Algorithms;Alkaloids;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Animal Model;anti-depressive agents;Antibody Therapy;Anxiety;Anxiety Disorders;APP-PS1;associated symptom;Automobile Driving;Biological Assay;Biological Availability;Blood;blood-brain barrier penetration;blood-brain barrier permeabilization;Botanicals;Brain;Cell model;Cellular Assay;Characteristics;Chemicals;Clinical;clinical candidate;Cognition;cognitive enhancement;cognitive function;Collection;Confusion;conventional therapy;cost;Coupled;Coupling;Data;Detection;Development;Diet;dietary;Disease;disease diagnosis;Dose;drug candidate;drug development;drug discovery;efficacy evaluation;efficacy validation;Ethnobotany;Exercise;Failure;Family;FDA approved;Fruit;Fungal natural products;Galantamine;Galanthus nivalis;Genetic Transcription;Goals;Hallucinogens;Hepatocyte;high throughput screening;holistic approach;Human;human induced pluripotent stem cells;Image;Impaired cognition;improved;In Vitro;in vitro Model;in vivo;in vivo evaluation;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Intervention;Ketamine;knowledge network;Lead;lead candidate;Life Style;Life Style Modification;Link;Literature;Measurement;Measures;Medicinal Herbs;Medicinal Plants;Memory;Memory Loss;Mental Depression;Mental Health;Metabolic;mild cognitive impairment;Modification;Molecular;molecular phenotype;Molecular Target;mouse model;Mus;Natural product discovery;Natural Product Drug;Natural Products;Nervous System Physiology;Neuromodulator;Neuronal Plasticity;Neurons;Neurosciences;Nootropic Agents;novel;Onset of illness;Pathology;Patients;Personal Satisfaction;Pharmaceutical Chemistry;pharmacologic;Pharmacologic Substance;Phase;Plant natural product;pre-clinical;presenilin-1;prevent;Process;Psyche structure;Quality of life;Recording of previous events;Reporter;Reporting;Reproducibility;Research;Resources;Safety;Sampling;screening;Signal Transduction;social;Source;stem cell model;Symptoms;Synapses;tau aggregation;tau Proteins;Therapeutic;therapeutic candidate;Therapeutic Uses;Time;transcriptomics;Translations;treatment duration

PROJECT_TITLE: A Drug Discovery Platform to Prioritize Development of Natural Product Neuromodulators for Treating Cognitive Impairment


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: VAN NUYS

ORG_NAME: TRACE-ABILITY, INC.

ORG_STATE: CA

PHR: ImmunoPET has proven to be a groundbreaking innovation yielding actionable medical information that is not otherwise obtainable in many disease areas. This project will enable nationwide availability of ImmunoPET by delivering the first-ever fully-automated production platform that can support a wide diversity of ImmunoPET tracers. HIV ImmunoPET was chosen for demonstration of this enabling platform due to the value of the imaging information coupled with it currently being limited to a single US site.

PI_NAMEs: ELIZAROV, ARKADIJ  (contact);VANBROCKLIN, HENRY F.

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TITLE: Improving availability of ImmunoPET via automation of radio-synthesis and quality control of antibody-based HIV imaging PET tracers on a single platform.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-Z (10)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: ROCKVILLE

ORG_NAME: SEETRUE TECHNOLOGY, LLC

PHR: PROJECT NARRATIVE Microinjection, which entails using a microcapillary needle to deliver foreign substances (e.g., e.g., nucleic acids, proteins, viruses, cells, and nanoparticles) into biological targets (e.g., cells, embryos, and tissues), is widely used for research and clinical applications ranging from animal-based genetic experimentation to fertility treatments, genetic diagnoses, and disease prevention modeling in humans. This proposal will evaluate the utility and performance of novel mechanically robust 3D-printed microcapillary needles compared to the current industry standard needles. This pending-patent direct laser writing design has the potential to simultaneously address customer pain points and bridge an important need in the microinjection industry.

PI_NAMEs: RAND, KINNERET  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: 3-Dimensional;3D Print;Address;Affect;Animals;Area;Biological;Biomedical Research;Blood capillaries;Brightfield Microscopy;Calibration;Carbon;Cells;Cellular biology;Clinical;clinical application;design;Developmental Biology;Dimensions;disorder prevention;DNA;Embryo;Engineered Gene;Event;Experimental Genetics;experimental study;Fertilization in Vitro;fundamental research;genetic disorder diagnosis;genetic manipulation;Geometry;Glass;Human;human disease;improved;In Vitro;in vivo;Industry;Industry Standard;infertility treatment;Injections;Injury;innovation;Innovation Corps;Lasers;Legal patent;manufacture;Marketing;Measures;mechanical properties;Mechanics;Mediating;Medical;Microinjections;Modeling;nanoparticle;Needles;novel;Nucleic Acids;Pain;Penetration;Performance;polymerization;Polymers;Preimplantation Diagnosis;pressure;Printing;Procedures;Productivity;programs;Proteins;Protocols documentation;prototype;Puncture procedure;Reliability of Results;Reproducibility;Research;Retrieval;Scientist;Side;stem cell genes;Structure;success;Survival Rate;Systems Biology;Techniques;Testing;Time;Tissues;Transgenic Organisms;Tube;two-photon;Virus;Visual;Work;Writing;Zebrafish

PROJECT_TITLE: MECHANICALLY ROBUST 3D-PRINTED MICROCAPILLARY NEEDLES WITH ANTI-CLOGGING CAPABILITIES

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-S (12)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Nutrition;Obesity;Precision Medicine;Prevention

ORG_CITY: Menlo Park

ORG_NAME: PHENOMIX SCIENCES, LLC

PHR: PROJECT NARRATIVE Obesity phenotypes, characterized by abnormalities in the components of food intake, such as abnormal postprandial satiety, may be useful to guide selection of lifestyle interventions, anti-obesity medications and endoscopic devices to enhance weight loss. The current method to identify obesity phenotypes is time- consuming, invasive, expensive, and not easily accessible. To address these limitations, in an academic-industry partnership, we developed and validated a novel blood- and saliva-based biomarker test to identify people with the abnormal postprandial satiety phenotype; we propose to study if this biomarker predicts greater weight loss response to semaglutide.

PI_NAMEs: BAGNALL, MARK  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Acceleration;Accreditation;Address;Adherence;Adult;Adverse event;Agonist;Appetite Regulation;Bariatrics;Biological Markers;biomarker driven;Blinded;Blood;Body mass index;Body Weight decreased;Calories;Chronic;Clinic;Clinical;clinical application;clinical practice;cohort;Cohort Studies;commercialization readiness;Consumption;cost;cost effective;Data;design;Devices;Disease;DNA;double-blind placebo controlled trial;Eating;Effectiveness;efficacy study;Enrollment;Enzyme-Linked Immunosorbent Assay;Exposure to;follow-up;Gastric Emptying;GCG gene;Genomic DNA;GLP-I receptor;Health Personnel;Heterogeneity;Hormones;Hour;Human;Hunger;individual patient;industry partner;Injections;Intervention;Laboratories;lifestyle intervention;liraglutide;Logistic Regressions;Machine Learning;Mass Spectrum Analysis;Measures;metabolomics;Methods;Modeling;Multicenter Trials;Names;novel;novel marker;obese patients;Obesity;Obesity Epidemic;obesity treatment;Outcome;Participant;Patient Recruitments;Patients;personalized approach;Persons;Pharmaceutical Preparations;Phenotype;Placebos;Positive Test Result;precision medicine;predicting response;predictive marker;predictive modeling;Prevalence;primary endpoint;Process;prospective;Prospective Studies;Publishing;Radiation exposure;Radioisotopes;Randomized;randomized placebo-controlled clinical trial;randomized, clinical trials;Recommendation;Relapse;response;Saliva;Sampling;Satiation;secondary endpoint;side effect;SNP array;subcutaneous;Test Result;Testing;Time;trait;treatment response;Validation;weight loss intervention

PROJECT_TITLE: A NOVEL PRECISION MEDICINE APPROACH FOR OBESITY: A RANDOMIZED, MULTI-CENTER TRIAL

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-K (10)]


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Orphan Drug;Rare Diseases

ORG_CITY: HUNTSVILLE

ORG_NAME: CFD RESEARCH CORPORATION

ORG_STATE: AL

PHR: Project Narrative: Keratoconus is the most common corneal disease often resulting in severe degradation of vision. Corneal crosslinking has proven to be a helpful palliative for keratoconus patients, slowing disease progression. However, cases of regression and a lack of data cast concern on the long-term effects and efficacy of this treatment. Combined with a lack of etiological knowledge of the disease, lack of a recognized animal model, and interest in both palliative and curative treatments from pharmaceutical companies creates a need for an advanced human, 3D in vitro model of the keratoconus cornea.

PI_NAMEs: ROEHM, KEVIN  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3-Dimensional;3D Print;Actins;Alginates;Animal Model;Anterior;Aqueous Humor;aqueous humor flow;Basic Science;Biochemical;Biochemical Markers;Biological Assay;Biological Markers;Bioreactors;Blindness;Cell model;cell type;Cells;chelation;Clinical;Clinical Data;Closure by clamp;Collagen;Communities;Complex;Cornea;Corneal Diseases;corneal epithelium;crosslink;curative treatments;Data;design;Development;Diagnosis;Disease;disease model;Disease Progression;Drug Transport;early detection biomarkers;Early identification;Early Intervention;Endothelial Cells;Environment;Epithelial Cells;Etiology;Evaluation;experience;Extracellular Matrix;Eye;Film;Fingerprint;fluid flow;Gel;Gene Expression;Geometry;Health Sciences;Human;hydrogel scaffold;Hydrogels;improved outcome;In Vitro;in vitro Model;in vivo Model;innovation;interest;irritation;Keratoconus;Keratoplasty;Knowledge;lens;Light;Long-Term Effects;Maps;Market Research;Marketing;Measurable;Measurement;Membrane;Methods;Modeling;Monitor;novel;novel therapeutic intervention;Outcome;palliative;Palliative Care;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Photoreceptors;Physiological;Physiology;Positioning Attribute;pressure;Procedures;protein expression;prototype;Pump;Research;Research Personnel;research study;Retina;Sales;Sampling;scaffold;Shapes;Side;Smooth Muscle;Source;Stains;Stromal Cells;Structure;success;Surface;Testing;Texas;Therapeutic;three-dimensional modeling;Time;Tissues;Treatment Efficacy;two-dimensional;Universities;Variant;Vision

PROJECT_TITLE: Advanced 3D model of the Human Cornea for Keratoconus


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Genetics;Nutrition

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE Manipulation of TORC1 signaling extends lifespan and increases disease resistance but has pleiotropic effects making it critical to understand novel downstream mediators, like pre-mRNA splicing, to better target interventions. The goal of this project is to investigate the mechanisms by which pre-mRNA splicing regulates TORC1 downstream processes including lipid metabolism and the causality for longevity. This work will expand our understanding of RNA homeostasis as a novel paradigm in aging and physiology and ultimately serve as a basis for the design of interventions to promote healthy aging and disease resistance.

PI_NAMEs: PEREZ MATOS, MARIA CAMILA (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Acetyl-CoA Carboxylase;age related;Aging;Alternative Splicing;Amino Acids;Binding;Biology of Aging;Caenorhabditis elegans;Cells;Complex;CRISPR/Cas technology;Data;Defect;Deposition;detection of nutrient;dietary requirement;dietary restriction;Disease;Disease Resistance;effective intervention;Enzymes;Etiology;extend lifespan;Fatty acid glycerol esters;Fatty Acids;Genes;Genetic Models;Goals;healthy aging;Homeostasis;Intervention;knock-down;Knowledge;Life Expectancy;Link;lipid metabolism;lipidome;Lipids;Longevity;Mammals;Mediating;Mediator;Metabolic Diseases;Metabolic dysfunction;Metabolic Pathway;Molecular;mRNA Precursor;novel;Osmosis;Pathway interactions;Phenocopy;Phenotype;Physiology;pleiotropism;Prevalence;Process;Regulation;Regulatory Pathway;RNA;RNA Splicing;Role;sensor;Signal Transduction;Sirolimus;Spliceosomes;Testing;therapy design;Tissues;Work

PROJECT_TITLE: RNA splicing regulation of lipid metabolism and longevity in C. elegans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Orphan Drug;Ovarian Cancer;Radiation Oncology;Rare Diseases;Women's Health Research

ORG_CITY: Coralville

ORG_NAME: VIEWPOINT MOLECULAR TARGETING, INC.

ORG_STATE: IA

PHR: Project Narrative The proposed project is relevant to public health because it will lead to the commercialization of a pretargeting platform for image-guided targeted alpha particle therapy for ovarian cancer. This technology will provide therapeutic option to treat a disease with poor outcomes and few effective therapies.

PI_NAMEs: HOUGHTON, JACOB ;SCHULTZ, MICHAEL KING (contact)

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: Adamantane;Alpha Particles;Antibodies;Benchmarking;Binding;Biodistribution;Biological Markers;cancer diagnosis;Cancer Patient;Capital;Cells;Cessation of life;Chelating Agents;chelation;Clinical;clinical research site;Clinical Trials;commercial application;commercialization;Cytotoxic Chemotherapy;Data;Diagnosis;Disease;Dose;dosimetry;effective intervention;effective therapy;Elements;Formulation;Future;Goals;Guidelines;Hematopoietic;Human;humanized monoclonal antibodies;Image;image guided;image guided therapy;imaging platform;Immunohistochemistry;immunoreactivity;improved;improved outcome;Injections;innovation;Isotopes;Kidney;Label;Licensing;Life;macromolecule;Malignant neoplasm of ovary;Malignant Neoplasms;Molecular;Molecular Target;Monoclonal Antibodies;Monoclonal Antibody CC49;mouse model;Mus;Mutation;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;Oncology;Operative Surgical Procedures;Outcome;Ovarian Serous Adenocarcinoma;overexpression;particle;particle therapy;Patient-Focused Outcomes;Patients;Phase;Phase I Clinical Trials;Preparation;Privatization;Production;programs;protocol development;Protocols documentation;Public Health;Published Comment;Radiation;Radioisotopes;Radiolabeled;radioligand;Radionuclide therapy;Radiopharmaceuticals;Recovery;Recurrence;Red Marrow;Relapse;response;Sampling;Secondary to;single photon emission computed tomography;Site;Small Business Innovation Research Grant;Small Business Technology Transfer Research;small molecule;Stains;standard of care;Structure;subcutaneous;success;TAG-72 Antigen;targeted treatment;Technology;Therapeutic;Therapeutic Index;Therapeutic Uses;Tissues;Toxic effect;Toxicology;tumor;Tumor Antigens;Tumor Debulking;tumor growth;United States

PROJECT_TITLE: Antibody-based prertargeted alpha particle therapy for ovarian cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-E (11)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Batten Disease;Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: FUQUAY VARINA

ORG_NAME: COLLABORATIONS PHARMACEUTICALS, INC.

ORG_STATE: NC

PHR: Narrative CLN1 disease (Infantile Neuronal Ceroid Lipofuscinosis, or Infantile Batten Disease) is characterized by progressive intellectual and motor deterioration, frequent seizures, loss of vision, and early death, caused by mutations in CLN1 gene, which codes for the lysosomal enzyme palmitoyl-protein thioesterase-1 (PPT1). Recombinant human PPT1 (rhPPT1) can be used as an enzyme replacement therapy for this ultra-rare disease and will ultimately improve the lives of children and families living with this devastating life-long disease for which there is currently no treatment. In our Phase I SBIR we have demonstrated statistically significant in vivo efficacy of rhPPT1 in mice and sheep, In our Phase II SBIR we have already submitted our preIND with a meeting scheduled for May 2023 and are currently generating GLP protein followed by IND-enabling toxicology studies. In preparation for a future clinical trial, we now propose 1. Production of GMP protein, 2. continue our quality documentation 3. prepare a clinical trial protocol and 4. submit an IND. The financial return on investment for this treatment is the FDA rare pediatric disease priority review voucher currently valued at ~$100M.

PI_NAMEs: EKINS, SEAN  (contact)

PROJECT_TERMS: Affect;Age Months;Animals;Behavioral;Beta-glucuronidase;Biochemical;Biological Products;Biophysics;Blindness;Brain;Brain region;Brazil;Caring;cell bank;Cell Line;Cessation of life;Child;Childhood;Chinese Hamster Ovary Cell;Clinic;Clinical Protocols;Clinical Research;clinical trial protocol;Clinical Trials;CLN1 gene;CLN2 gene;Code;Collaborations;commercialization;cost;Cyclic GMP;Data;Dementia;Deterioration;Development;Development Plans;Disease;disease phenotype;Documentation;Dose;enzyme activity;enzyme pathway;enzyme replacement therapy;Enzymes;Epilepsy;expectation;experience;Family;fighting;Formulation;Future;Gait;gene therapy;Genes;Health system;Hospitalization;Human;improved;in vivo;infancy;Infantile neuronal ceroid lipofuscinosis;Innovation Corps;interest;International;intravenous administration;Investments;Licensing;Live Birth;Lysosomal Storage Diseases;manufacture;Marketing;meetings;Mole the mammal;Motor;Mus;Mutation;Nerve Degeneration;neuron loss;Neuronal Ceroid-Lipofuscinosis;neuropathology;Orphan;Orphan Drugs;Outcome Measure;Palliative Care;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase;phenotypic data;Physicians;Population;Positioning Attribute;Preparation;Prevalence;Procedures;Process;Production;programs;Proteins;Protocols documentation;Rare Diseases;Rattus;Recombinants;Reporting;Retina;Role;Rotarod Performance Test;Route;Schedule;Seizures;Services;Sheep;Small Business Innovation Research Grant;Spielmeyer-Vogt Disease;Spinal Cord;System;Taxes;thioesterase PPT1 gene product;Toxic effect;Toxicology;Training;Translating;Translations;treatment effect;United States National Institutes of Health;voucher;Work;Writing;young adult

PROJECT_TITLE: Manufacture of an intracerebroventricular Enzyme Replacement Therapy for CLN1 Batten Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-K (19)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: KENSINGTON

ORG_NAME: SPIRIT FIT & HEALTH INC

PHR: For this project, we (SPIRIT Club) will develop a post-acute, rehabilitation program for people with a chronic brain injury (CBI). We will build an on-demand, evidence-based, stakeholder- informed pathway that includes virtual fitness programming and educational material for adolescents and adults living with persistent cognitive and physical impairments associated with CBI. This CBI-specific programing will be evaluated using a randomized clinical trial to test its utility as a mechanism to promote physical activity and wellness among CBI survivors.

PI_NAMEs: CINER, JARED PHILLIP (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Acute;Address;Adolescent;Adult;Area;arm;brain health;Brain Injuries;Businesses;Caregivers;Chronic Brain Injury;Clinical;commercialization;Communities;comparative efficacy;cost;Country;design;disability;Disabled Persons;Educational Curriculum;Educational Materials;Ensure;evidence base;Exercise;exercise program;experience;Family;fitness;Fitness Centers;formative assessment;Future;General Population;Goals;Health;Health Promotion;Health Resources;Home environment;Impaired cognition;improved;improved outcome;Individual;Industry;Injury;innovation;Intellectual functioning disability;Intervention;Learning Module;Mainstreaming;Maintenance;Medical center;member;Mission;Motor;National Institute of Child Health and Human Development;novel;Participant;Pathway interactions;Patients;Persons;Phase;Physical activity;Physical Exercise;Physical Fitness;physical impairment;Physical Rehabilitation;pilot test;Process;programs;prototype;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;rehabilitation research;Rehabilitation therapy;Research;Research Priority;Resolution;Self Efficacy;Small Business Innovation Research Grant;Stream;Stroke;Survivors;Technology;Testing;therapy design;Training;Trauma;treatment arm;treatment group;tumor;user-friendly;virtual;virtual platform

PROJECT_TITLE: SPIRIT Club CBI Pathway: A novel streaming platform for physical activity and wellness promotion for chronic brain injury survivors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-J (10)]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Sleep Research;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: SILVER SPRING

ORG_NAME: INOVCARES CONNECTED COMPREHENSIVE HEALTHCARE CORPORATION

PHR: Project Narrative Maternal mortality and morbidity are serious public health concerns in the United States, particularly among non- Hispanic Black women based on the 2021 CDC report that states that a woman’s risk of maternal mortality is 3- 4 times higher if she is black compared to white. Although there are few healthcare systems that facilitate care coordination, they lack maternal telehealth option necessary to optimize access, while others that provide the telehealth option, lack several integrated features such as training the providers for cultural competency, prescription ordering and delivering, tracking, and rewarding healthy life-style changes. InovCares technology plans to use all these integrated features to evaluate the effectiveness of their patented Health-Tribe platform in pregnant women for generating a health assessment report that identifies risks associated and provides guidance for adopting behavioral changes necessary and assessing maternal mental health with care coordination for better maternal outcomes.

PI_NAMEs: KAMARA, MOHAMED  (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Abnormal coordination;Address;Adherence;Adopted;Age;Artificial Intelligence;Assessment tool;Behavior Therapy;Behavioral;Birth;Black race;black women;Blood Pressure;Cardiometabolic Disease;Cardiomyopathies;Cardiovascular system;care coordination;care systems;Caring;Child health care;Chronic;Client satisfaction;Clinical;Cognitive Therapy;Communities;community based care;Compassion;Complement;Comprehensive Health Care;Consultations;cost;Country;cultural competence;Data;Death Rate;delivery complications;depressive symptoms;Detection;Developed Countries;Development;Diastolic blood pressure;digital;digital health;Discipline of obstetrics;Disparity;Disproportionately impacts women;effectiveness evaluation;efficacy evaluation;Emotional;Equity;Family;fetal;Fetal health;Fetal Mortality Statistics;Focus Groups;Fostering;Frequencies;Health;health assessment;Health Insurance Portability and Accountability Act;Health system;Healthcare;Healthcare Systems;healthy lifestyle;Hemorrhage;Hour;Hypertension;improved;improvement on sleep;Infection;innovation;integrated care;interpersonal therapy;Intervention;Legal patent;Link;Maternal and Child Health;Maternal Health;Maternal Health Services;maternal morbidity;Maternal Mortality;maternal outcome;maternal risk;Medical;Mental Depression;Mental Health;mobile application;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;Not Hispanic or Latino;novel;Outcome;Participant;Patient Education;Patients;peer;peer support;perceived stress;perinatal women;Persons;Phase;Physicians;Postpartum Depression;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnant;Pregnant Women;programs;Provider;Public Health;racial disparity;Randomized, Controlled Trials;Recommendation;Reporting;Research Personnel;Rewards;Risk;Risk Assessment;Risk Factors;Rural;satisfaction;Sleep;sleep quality;Small Business Technology Transfer Research;social health determinants;Social Interaction;sociodemographic factors;Stress;stress reduction;Support Groups;Technology;technology development;telehealth;telemonitoring;Telephone;Text Messaging;Training;tribal health;United States;United States National Aeronautics and Space Administration;Videoconferencing;virtual;White Women;Woman;women of color

PROJECT_TITLE: Efficacy of a culturally-sensitive telehealth platform in fostering community-based care coordination for respectful maternal mental health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (10)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Pregnancy-capable Veterans experience an elevated risk of adverse reproductive health outcomes compared to the civilian population because of a confluence of trauma, combat exposure, and other exposures that may affect health outcomes and the development of comorbid mental, physical, and psychosocial conditions, such as autoimmune conditions. The proposed mixed methods study aims to understand and triangulate the multi- level quality and access barriers to contraceptive care Veterans with autoimmune conditions may experience using three different, rich Veterans Health Administration data sources: electronic health record data, medical record text notes, and qualitative interviews. The results from the proposed research will provide a strong foundation for developing interventions and policies to promote high-quality contraceptive care for a population at high risk of adverse reproductive health outcomes.

PI_NAMEs: PLEASURE, ZOE HYPATIA (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: adverse outcome;Affect;analytical method;Autoimmune;Autoimmune Diseases;care coordination;care delivery;Caring;Characteristics;Clinical;combat;comorbidity;Complex;Computer software;Contraceptive Agents;Contraceptive methods;Counseling;Coupled;Data;Data Sources;Development;Diagnosis;Disability status;Discrimination;Disease;Documentation;Electronic Health Record;electronic structure;Equity;experience;Foundations;Fright;Funding;gaps in access;Gastroenterology;General Population;Goals;Growth;Hashimoto Disease;Health;Health Personnel;Health Services Accessibility;Healthcare;High Prevalence;high risk;Hospitals;improved;Individual;Inflammatory Bowel Diseases;Intervention;Interview;Intrauterine Devices;marginalization;Medical Records;Mentorship;Methods;Minority;Modeling;Multiple Sclerosis;Natural Language Processing;novel;Outcome;patient oriented;patient population;Patient-Centered Care;Patients;Persons;Pharmaceutical Preparations;pill;Policies;Population;Pregnancy;prescription document;Primary Care;Provider;Psyche structure;psychosocial;Quality of Care;racial identity;racial minority;reproductive;Reproductive Health;Reproductive History;reproductive outcome;Research;Research Personnel;Rheumatoid Arthritis;Rheumatology;Risk;same-sex partnership;Sampling;Severities;Stress;Structure;System;Systemic Lupus Erythematosus;Teratogens;Text;Training;Trauma;United States Health Resources Administration;United States National Institutes of Health;Veterans;Veterans Health Administration;Woman

PROJECT_TITLE: Improving Contraceptive Care for Pregnancy-Capable Veterans with Autoimmune Conditions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Genetics;Human Genome;Rare Diseases

ORG_CITY: AUSTIN

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Narrative Patients with mitochondrial disease experience major issues in diverse organs such as the eye, ear, brain, muscle, and kidney. Understanding how mitochondrial DNA (mtDNA) variations contribute to health and disease has been hampered by a lack of effective approaches to generate animal models of these diseases. This proposal is to make a new mtDNA CRISPR-based genome engineering toolkit to develop the first conditional models of mitochondrial disease using the zebrafish.

PI_NAMEs: EKKER, STEPHEN CARL (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Affect;Aging;Animal Disease Models;Animal Model;Apoptosis;base editing;base editor;BCAR1 gene;bioinformatics tool;Biological;Biological Models;Biology;Brain;Cell Nucleus;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Complement;design;Development;Disease;disease classification;disease model;DNA;Ear;Elements;empowerment;Engineering;Environment;experience;Eye;Functional disorder;gene complementation;gene editing technology;Generations;Genes;Genome;genome editor;Genome engineering;genomic variation;Genomics;Goals;Guide RNA;Health;heteroplasmy;Homeostasis;Human;In Vitro;in vivo;in vivo Model;Individual;innovation;insight;interest;Kidney;Liver;MELAS Syndrome;Metabolism;Methods;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial genome;Mitochondrial RNA;Modeling;Molecular;Muscle;Nature;novel;Nuclear;Nucleic Acids;Nucleotides;Organ;Outcome;Pathogenicity;Patients;Proteins;RNA;RNA Sequences;Severity of illness;System;Testing;Therapeutic Intervention;Tissues;tool;Transcript;transcriptomics;Transgenic Organisms;Variant;Work;Zebrafish

PROJECT_TITLE: Conditional Animal Models of mtDNA Disease

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative Positive affective stimuli have been shown to improve therapeutic outcomes in the treatment of generalized anxiety disorders but how positive affective states interact with negative affective emotions to facilitate the compartmentalization, reconsolidation, or extinction of generalized fear-related memories is not clear. We find that a positive reinforcer can prevent, reverse, or facilitate the extinction of a generalized threat memory in a dopamine-dependent manner. We will test whether increased dopamine release in the CeA in response to a positive affective stimulus may be an important neural substrate underlying the ability of positive emotional stimulus to suppress threat generalization.

PI_NAMEs: ZWEIFEL, LARRY S (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Address;Affective;Amygdaloid structure;anxiety-related disorders;Appetitive Behavior;Aversive Stimulus;Behavior;behavior influence;Behavioral;Brain;Brain region;Calcium;Cell Nucleus;cell type;Cells;cellular imaging;Clinical;Code;Cognitive Therapy;Conditioned Stimulus;conditioning;Cues;Data;Desire for food;Detection;Discrimination;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;dopaminergic neuron;DRD1 gene;Effectiveness;Electrophysiology (science);emotional stimulus;Emotions;Extinction;Food;foot;Fright;Generalized Anxiety Disorder;Genetic;Image;Imaging Techniques;Impairment;improved;insight;integration site;Learning;Measures;Memory;memory recall;memory retention;Methods;Midbrain structure;Modification;Monitor;Motivation;Mus;Nature;negative affect;Negative Valence;neural;Neurons;Neurotransmitter Receptor;Neurotransmitters;optogenetics;Outcome;Pain;Panic Disorder;Phobias;Play;Positive Reinforcements;Positive Reinforcer;Positive Valence;Post-Traumatic Stress Disorders;prevent;Probability;Psychological reinforcement;Ramp;Regulation;Repression;response;Response Generalization;Rewards;Sensory;Shock;Site;Social Anxiety Disorder;Stimulus;Stress;Sucrose;Testing;therapy outcome;tool;Uncertainty;Ventral Tegmental Area;Viral

PROJECT_TITLE: Appetitive and aversive state interactions in the central amygdala during learning and memory

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: BIRMINGHAM

ORG_NAME: CLARET BIOSCIENCE, LLC

ORG_STATE: MI

PHR: PROJECT NARRATIVE The project aims to develop a robust, molecular profiling tool and a target-enrichment assay for early detection and monitoring of cancer using microRNAs (miRNA), a group of vital small RNA molecules. Claret Bioscience will develop a novel method specifically for miRNA based on a proprietary technology that efficiently generates sequencing libraries from minimally abundant, short, nucleic acids fragments. The resultant next-generation sequencing assay will enable more precise cancer diagnosis by accurately measuring changes in composition and abundance of miRNA in tumor and liquid biopsies and enable novel biomarker discovery and evaluation of newly designed miRNA therapeutics.

PI_NAMEs: RAO, VARSHA  (contact)

PROGRAM_OFFICER_NAME: NOVA, IAN CURTIS

PROJECT_TERMS: accurate diagnosis;Biological;Biological Assay;Biological Sciences;Biological Testing;Biology;biomarker discovery;biomarker evaluation;cancer diagnosis;cancer type;circulating biomarkers;circulating microRNA;Clinical;clinical application;Complex;cost effective;design;detection limit;Development;Diagnostic;differential expression;dimer;Disease;disease diagnosis;Disease Progression;early detection biomarkers;Early Diagnosis;efficacy testing;Enzymes;Excision;Generations;Genetic Transcription;improved;Industry;insight;Knowledge;Laboratories;Length;Libraries;Ligase;Ligation;liquid biopsy;Liquid substance;Malignant Neoplasms;Measures;Methodology;Methods;microRNA biomarkers;MicroRNAs;miRNA expression profiling;Modeling;Modification;Molecular;Molecular Diagnostic Testing;Molecular Profiling;Monitor;mRNA Expression;mRNA Translation;next generation sequencing;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;novel;novel marker;novel strategies;Nucleic Acids;Nucleotides;Oligonucleotides;Oncogenic;Oncology;Outcome;Pathogenicity;Patients;Phase;Phenotype;Play;Preparation;Process;Protein Biosynthesis;protein expression;Protocols documentation;Quality Control;rapid technique;Reaction;Reagent;Regulation;Research;Resolution;response;Reverse Transcription;RNA Interference Therapy;Role;Sampling;Screening for cancer;Small RNA;Splint Device;Standardization;Stimulus;success;Technology;technology development;Therapeutic;therapeutic miRNA;Tissues;tool;transcriptome sequencing;treatment response;tumor;Untranslated RNA;Variant;Work

PROJECT_TITLE: A rapid method for global and targeted miRNA next generation sequencing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-V (13)]


NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative  Legionella pneumophila is a human pathogen that uses multiple effector proteins to inhibit translation within its host cell; however, our knowledge of how and when these proteins function during infection is incomplete. This proposal seeks determine the mechanism for one of these effectors and establish a framework for when the various translation-inhibiting effectors are active during infection. Discoveries stemming from this proposal will increase our understanding of Legionella which may be useful for antibiotic drug design but could also yield new insights into our own cell biology since these effectors undermine fundamental processes within the host cell.

PI_NAMEs: BLACK, JOSHUA J (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: antibiotic design;Antibiotics;Bacteria;Biochemical;Biochemical Process;Biochemistry;Biological;Biological Process;Cells;Cellular biology;Complex;Data;Degradation Pathway;Drug Design;Enzymes;experimental study;FRAP1 gene;Global Change;glycosyltransferase;Hour;Human;human disease;human pathogen;In Vitro;Incidence;Individual;Infection;insight;Intervention;Investigation;Knowledge;Legionella;Legionella pneumophila;Legionnaires' Disease;Molecular;Molecular Chaperones;Molecular Target;Monitor;Nature;novel;pathogen;Pathogenesis;pharmacologic;Phosphotransferases;Physiological;Pneumonia;Process;Protein Biosynthesis;protein degradation;protein function;Protein Synthesis Inhibition;Proteins;rational design;Reaction;Regulation;Regulatory Pathway;Ribosomes;Serine Protease;stem;Techniques;translation factor;Translation Initiation;translational framework;Translational Repression;Translations;United States;Work

PROJECT_TITLE: Characterizing host translation inhibition by Legionella pneumophila

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Immunization;Infectious Diseases;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SUNNYVALE

ORG_NAME: PANORAMA RESEARCH, INC.

PHR: Narrative Periodontal disease affects almost half of Americans 30 years and older. Advanced periodontal disease leads to retraction of the gums from the teeth and ultimately loss of teeth. A key step in progression of periodontitis involves the loss of alveolar bone that provides the underlying support for the tooth. This process involves the bone-degrading cells, whose importance in periodontitis is now recognized. We have identified a novel approach to halt the destruction of bone and to prevent tooth loss.

PI_NAMEs: BOR, BATBILEG ;LARRICK, JAMES W (contact);MENDELSOHN, ANDREW R

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Adult;advanced disease;Affect;Affinity;Alveolar Bone Loss;American;Animals;Antibodies;Attenuated;Bacteriophages;Binding;bone;Bone Diseases;bone erosion;bone loss;bone mass;bone resorbing activity;Cells;Data;Dendritic Cells;Diabetes Mellitus;Drug Kinetics;Enzyme-Linked Immunosorbent Assay;Exhibits;Goals;Homeostasis;Human;human monoclonal antibodies;in vitro Assay;Inflammation Mediators;Integral Membrane Protein;Interruption;Knock-in Mouse;Knock-out;Knockout Mice;Lead;Letters;Libraries;Ligature;Mediating;Mediator;Methods;Modeling;Monoclonal Antibodies;monocyte;mouse model;murine monoclonal antibody;Mus;novel strategies;novel therapeutics;osteoclast progenitor;osteoclastogenesis;Osteoclasts;Periodontal Diseases;Periodontitis;Phase;precursor cell;prevent;Process;Role;Signal Transduction;stem cells;Testing;Therapeutic Intervention;Time;TNFSF11 gene;Tooth Loss;Tooth structure;Toxic effect;Work

PROJECT_TITLE: Novel therapy to prevent alveolar bone loss in severe periodontitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-D (10)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: COLUMBIA

ORG_NAME: ACEPRE, LLC

ORG_STATE: SC

PHR: Project Narrative Calcific aortic valve disease (CAVD), the third leading cause of heart disease, has higher incidence in men than women and that aortic valve calcification may be affected by congenitally bicuspid aortic valve disease and levels of cytokine transforming growth factor beta1. Unfortunately, there is no medical treatment, and without surgery, calcific aortic valve disease leads to death. In this project we will use unique preclinical mouse model of CAVD to determine mechanisms involved in the pathogenesis of CAVD, and test if the natural compound emodin can attenuate and/or reverse aortic valve calcification.

PI_NAMEs: AZHAR, MOHAMAD  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Adult;Affect;Age;Age Months;Age Years;Animal Model;Aorta;aortic valve;aortic valve disorder;aortic valve replacement;Aortic Valve Stenosis;Atherosclerosis;Attention;Attenuated;bicuspid aortic valve;Binding;Biochemical;Biological Assay;Bone Marrow;calcification;Cell Lineage;Cells;Cessation of life;clinically relevant;confocal imaging;Cyclic GMP;cytokine;Data Set;Deposition;Development;Disease;disease model;Dose;drug development;Drug Kinetics;Emodin;FDA approved;Female;Fibroblasts;Functional disorder;Heart;Heart Diseases;Heart failure;Histology;Homeostasis;Human;human old age (65+);human very old age (85+);Hypertension;Impairment;improved;In Vitro;in vivo;in vivo monitoring;Incidence;insight;interstitial cell;Investigational New Drug Application;Laboratories;Lead;Left Ventricular Function;male;manufacture;Maps;Medical;Membrane;men;microCT;Minerals;mouse model;Mus;Myocarditis;Natural Compound;novel;novel therapeutics;older patient;Operative Surgical Procedures;Osteoblasts;overexpression;Pathogenesis;Patients;Pericytes;Pharmaceutical Preparations;Phase;Physiological;Play;Population;pre-clinical;research and development;response;restraint;Risk Factors;safety testing;Sclerosis;sex;Signal Transduction;Site;Small Business Technology Transfer Research;South Carolina;Specimen;standard of care;Stenosis;Surgical Valves;Testing;TGFB1 gene;Therapeutic;Toxic effect;Transforming Growth Factor beta;Transgenic Mice;Transgenic Organisms;Treatment Efficacy;Ultrasonography;Universities;valve replacement;Woman

PROJECT_TITLE: Develop natural compound emodin as a novel therapy for calcific aortic valve disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (10)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Neurosciences;Orphan Drug;Rare Diseases

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative Small cell lung cancer (SCLC) exhibits distinct biological subsets, including strongly neuroendocrine and low neuroendocrine (low-NE) subsets, with recent data linking low-NE SCLC to improved responses to immune checkpoint blockade in patients. Lack of mouse models of low NE-SCLC has been a barrier to progress in the field, which we will overcome using mouse models that overexpress the REST repressor of neural/neuroendocrine state. Our preliminary data also link REST to chemotherapy resistance; we will model low-NE SCLC and test the impact of REST activity on responses to chemotherapy and immune checkpoint blockade.

PI_NAMEs: MACPHERSON, DAVID  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Antigen Presentation;ASCL1 gene;Automobile Driving;BETA2 protein;Biological;Biology;Cancer Biology;Cancer Model;Cancer Patient;cancer subtypes;cancer therapy;CD8-Positive T-Lymphocytes;Cell Line;Chemoresistance;chemotherapy;Cleavage Under Targets and Release Using Nuclease;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR-mediated transcriptional activation;Data;Data Set;Epithelial Cells;Etoposide;Exhibits;gain of function;Gene Expression;Gene Mutation;Genes;Genetic Transcription;Genetically Engineered Mouse;Heterogeneity;Human;Immune;immune checkpoint blockade;immunogenicity;Immunohistochemistry;improved;in vivo;Kinetics;lentivirally transduced;Libraries;Link;loss of function;Lung;lung cancer cell;Mining;Modeling;Molecular Analysis;Molecular Target;mouse model;Mus;neoantigens;neural;Neurons;Neurosecretory Systems;novel;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patients;Phenotype;Platinum;programmed cell death ligand 1;programmed cell death protein 1;programs;Publishing;Reagent;Repression;Resistance;response;Role;small cell lung carcinoma;Switch Genes;T cell infiltration;Testing;Therapeutic;TP53 gene;Transcriptional Silencer Elements;transcriptome sequencing;treatment response;tumor;tumor-immune system interactions

PROJECT_TITLE: Interrogating roles for REST in small cell lung cancer therapy response and resistance

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences;Pediatric;Prevention;Primary Health Care

ORG_CITY: SAINT LOUIS

ORG_NAME: TURING MEDICAL TECHNOLOGIES INC

ORG_STATE: MO

PHR: Project Narrative Magnetic resonance imaging (MRI) has unrivaled clinical utility, is non-invasive, and provides extremely high spatial resolution; however, MRIs have one severe limitation: patient motion during an MRI scan diminishes the quality of the resulting images. Despite this fact, motion is not currently monitored during clinical MRI scans. The goal of this application is to complete and commercialize an accurate and non-invasive software-based solution for monitoring and reducing patient motion during brain MRIs.

PI_NAMEs: BERTOLERO, MAXWELL ;BRUENER, KEN  (contact)

PROGRAM_OFFICER_NAME: GRABB, MARGARET CHRISTINE

PROJECT_TERMS: Adoption;Agreement;anatomic imaging;Anesthesia procedures;Award;base;Benchmarking;Biofeedback;Brain imaging;brain magnetic resonance imaging;Brain Mapping;Breakthrough device;Child;Child health care;Childhood;Client;Clinical;clinical care;clinical development;Collection;commercialization;commercialization readiness;Complex;Computer software;cost;Data;Decision Making;Devices;Diffusion;Diffusion Magnetic Resonance Imaging;empowerment;Engineering;Ensure;Environment;Family;Feedback;Focused Ultrasound Therapy;Functional Magnetic Resonance Imaging;Goals;Grant;Head;Health;Healthcare Systems;Hospitals;Image;improved;industry partner;Institution;Letters;Magnetic Resonance Imaging;Manufacturer;Marketing;Medical;Mental Depression;Monitor;Morphologic artifacts;Motion;Movement;Movement Disorders;MRI Scans;neuroimaging;neuroregulation;novel;Pathway interactions;Patients;Pediatric Hospitals;pediatric patients;Physiologic pulse;Positioning Attribute;Predisposition;Price;programs;Protocols documentation;Questionnaires;Radiology Specialty;Randomized;Research;Resolution;Risk;Sales;satisfaction;Scanning;Source;Specific qualifier value;Speed;success;Tablets;Testing;Time;usability;Visual;wasting;Work

PROJECT_TITLE: Commercialization readiness of motion-robust brain MRI for pediatric healthcare


NIH_SPENDING_CATS: Biotechnology;Immunization

ORG_CITY: ELLICOTT CITY

ORG_NAME: GLYCOT THERAPEUTICS, LLC

PHR: Project Narrative Conjugation of various functional molecules to antibodies are frequently used for a wide variety of applications within the life science sectors. In the proposed research, GlycoT will employ its proprietary chemoenzymatic one-pot glycan-remodeling platform to establish a facile, robust, and scalable site-specific antibody conjugation technology.

PI_NAMEs: ZONG, GUANGHUI  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Ablation;Adopted;Affinity;Amaze;Antibodies;Antibody Affinity;antibody conjugate;antibody detection;antibody engineering;Antibody-drug conjugates;Antigens;Azides;Binding;Biological Sciences;cancer therapy;Cellulose;Chimeric Proteins;Clinical;Clinical Trials;Collaborations;Cysteine;Cytotoxic agent;design;Development;Disaccharides;Drug Kinetics;efficacy study;Endoglycosidases;Engineering;Enzymes;Evaluation;Exatecan;Excision;Galactosyltransferases;Glycoengineering;glycosylation;Goals;Half-Life;Hematology;Hepatotoxicity;Human Engineering;Image;Immunoglobulin G;improved;In Vitro;in vitro testing;in vivo evaluation;industrial production;Industrialization;Label;Licensing;Link;Lysine;manufacture;manufacturing process;manufacturing scale-up;Methods;mutant;Phase;phase 2 study;Polysaccharides;Positioning Attribute;Process;Reaction;Research;research and development;Research Personnel;Rodent Model;Route;scale up;screening;Serum;Services;side effect;Site;Streptococcus pyogenes;System;Technology;Testing;Therapeutic;Therapeutic Index;Toxic effect;Trastuzumab;tumor;Uridine Diphosphate Galactose

PROJECT_TITLE: Development of streamlined one-pot chemoenzymatic glycan remodeling systems for antibody conjugation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-G (10)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_NAME: MEDIOMICS, LLC

PHR: Despite widespread recognition of the important functions of RNA modifications, there are no commercially available products that can be used to monitor and image site-specific RNA modifications in cells and tissue samples. We propose to develop novel fluorescence-based methods and reagents for the sequence-specific imaging of RNA modifications. Our methods could become the first standard approach for analyzing RNA modifications in any sample, and will enable researchers to perform fluorescence imaging for RNA modifications in important biological and clinical samples, including brain and cancer samples.

PI_NAMEs: TIAN, LING  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Acute Myelocytic Leukemia;Adenosine;Affinity;Antibodies;base;Base Sequence;Binding;Biological;Biological Assay;Biology;Brain;Cell Culture System;Cell Differentiation process;cell fixing;Cell model;Cells;cellular imaging;Clinical;clinical prognostic;commercialization;commercialization readiness;cost;Databases;Deposition;design;Detection;detection sensitivity;Diagnostic;Disease;epitranscriptomics;Exhibits;Fluorescence;fluorescence imaging;fluorophore;Glioma;Goals;Heat-Shock Response;Human;Image;Inosine;interest;Laboratories;large datasets;Link;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Measures;Medicine;Messenger RNA;Methodology;Methods;Methylation;MicroRNAs;Modeling;Modification;Monitor;neurogenesis;novel;novel strategies;Pathway interactions;Performance;performance tests;Permeability;Phase;Phylogenetic Analysis;Protocols documentation;Pseudouridine;Reagent;Research Personnel;response;Ribose;Ribosomal RNA;RNA;RNA Decay;RNA Editing;RNA methylation;RNA Sequences;RNA Splicing;Sampling;Signal Transduction;Site;Small Nuclear RNA;Spermatogonia;Stains;stem cell proliferation;stoichiometry;System;Techniques;Technology;Testing;Tissue Sample;tool;Transcript;transcriptome;Transfer RNA;Translations;tumor;tumorigenesis;UV induced DNA damage;Validation;Variant;Work;X Inactivation

PROJECT_TITLE: Fluorescence-based sequence-specific imaging of RNA modifications

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-J (10)]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Biomedical Imaging;Data Science;Genetics;Networking and Information Technology R&D (NITRD);Osteoarthritis;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Osteoarthritis (OA) is the most common form of arthritis, but no disease-modifying drugs exist. Hence, treatment is limited to pain medication, exercise and weight loss, or ultimately total joint replacement. This project develops imaging genetics approaches based on sensitive image biomarkers to allow for genome-wide association studies (GWAS) across multiple large-scale image datasets with the goal of identifying genes associated with early signs of OA as promising targets for future drug developments.

PI_NAMEs: NIETHAMMER, MARC  (contact);ZHU, HONGTU

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: 3-Dimensional;Affect;Analgesics;Architecture;Area;Arthritis;Atlases;base;biobank;Biological Markers;Biology;Biometry;Body Weight decreased;bone;bone imaging;Brain Diseases;Cardiovascular Diseases;Cartilage;Clinical;Clinical Data;Clinical Pathways;cohort;Communities;Complex;Computer software;County;Data;Data Analyses;data exploration;Data Set;deep learning;Degenerative polyarthritis;Democracy;Development;Diagnosis;Disease;DNA;drug development;drug efficacy;Dual-Energy X-Ray Absorptiometry;Early identification;Environmental Risk Factor;Exercise;experience;Experimental Designs;Family;Future;Genes;Genetic;genetic analysis;genetic approach;genetic architecture;genetic association;Genetic Drift;Genetic Markers;Genetic study;genome wide association study;genome-wide analysis;Goals;Heart Diseases;Heritability;heterogenous data;high dimensionality;Image;Image Analysis;imaging approach;imaging biomarker;imaging genetics;imaging modality;improved;Industry;International Classification of Disease Codes;interoperability;Joints;Journals;Kidney Diseases;Knee Osteoarthritis;Knowledge;large-scale imaging data;Learning;Link;Magnetic Resonance Imaging;Maps;Measures;Meta-Analysis;multimodal data;Musculoskeletal;musculoskeletal imaging;Nature;Neurodegenerative Disorders;neuropsychiatric disorder;novel;Online Systems;open source;Outcome;Pain management;Pathway interactions;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Phenotype;Population;Population Study;precision medicine;predictive modeling;prevent;Quality Control;radiological imaging;Replacement Arthroplasty;Reporting;Reproducibility;Reproducibility of Results;Research;Resort;Retinal Diseases;Risk Factors;Sample Size;Sampling;Science;Shapes;Site;software development;Software Engineering;Specificity;success;System;Testing;Treatment Cost;Twin Multiple Birth;United States;Variant;web portal;Width;Work

PROJECT_TITLE: A comprehensive imaging genetics framework for osteoarthritis research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-F (02)]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Infectious Diseases

ORG_CITY: DOYLESTOWN

ORG_NAME: FOX CHASE CHEMICAL DIVERSITY CENTER, INC

PHR: Our goal is to develop the first approved drug for treating molluscum contagiosum (MC), a viral skin disease that afflicts mainly children and immune-compromised individuals. This drug will be for topical use to specifically target the highly contagious MC virus which causes multiple lesions anywhere on the skin. Importantly, these viral lesions can also occur on the eyelids and affect the conjunctiva of the eye itself. For this latter reason especially, the MC topical must be extremely safe. This MC drug is intended to alleviate the morbidity, physical suffering and psychological distress experienced by millions of children!

PI_NAMEs: RICCIARDI, ROBERT PAUL (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: 3-Dimensional;Acute contagious conjunctivitis;Address;Affect;Amides;Amino Acids;analog;Anti-viral Agents;aqueous;Area;Binding;Binding Proteins;Cells;Chemicals;Child;Cicatrix;Clinical Drug Development;conjunctiva;Conjunctivitis;cytotoxicity;Dermal;design;Development;Distal;Dose;Esters;Exhibits;experience;Eye;Eyelid structure;Face;FDA approved;Formulation;Future;genotoxicity;Goals;Hydrogen Bonding;Immune;improved;In Vitro;in vitro Assay;Individual;Infection;Inflammation;Intervention;Lead;Lesion;Liposomes;loss of function;manufacture;Measurable;Medical;Medicine;Methylation;Molluscum Contagiosum;Molluscum contagiosum virus;Morbidity - disease rate;Nitrogen;Pain;Penetration;peptide analog;peptide drug;Peptides;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phototoxicity;Physical Sufferings;Plasma Proteins;Poxviridae;pre-clinical;preclinical development;Proteins;psychological distress;risk mitigation;Safety;scale up;screening;Side;Site;Skin;skin disorder;skin lesion;small molecule;Solubility;System;Testing;tissue culture;Topical application;Toxic effect;transmission process;uptake;Validation;Valine;Viral;Viral Skin Diseases;Virus;Virus Replication

PROJECT_TITLE: Development of a Peptide-Drug Conjugate for Topically Treating the Viral Skin Disease Molluscum Contagiosum

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-F (12)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Patient Safety;Rare Diseases

ORG_CITY: Newburyport

ORG_NAME: ENCLEAR THERAPIES, INC.

PHR: Project Narrative Therapeutic compound access to the brain is tightly regulated by the blood brain barrier (BBB), severely restricting molecules entering the central nervous system (CNS) via the cerebral circulation – as an alternative drug delivery avenue, access has been attempted via the cerebral spinal fluid (CSF). The EnClear technology overcomes this challenge by delivering CNS drugs directly to target, continuously monitoring CSF flow and pressure dynamics, titrating drug infusion, augmenting flow rate, changing CSF flow direction, and oscillating CSF to hold drug concentration over a target region. The EnClear system will improve the outcomes of patients with neurological disease by delivering needed therapeutics, in a precise personalized manner that overcomes the issue of poor CNS penetration.

PI_NAMEs: GLICKSMAN, MARCIE A (contact)

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Address;Adverse effects;Adverse event;Affect;Age;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Model;animal safety;Animals;Antisense Oligonucleotides;Area;authority;Autopsy;Axon;Basal Ganglia;Behavior;Blood - brain barrier anatomy;Brain;brain parenchyma;brain tissue;Catheters;Central Nervous System;Central Nervous System Agents;Central Nervous System Diseases;Cerebral Ventricles;Cerebrospinal Fluid;Cerebrovascular Circulation;Cerebrum;Characteristics;Circulation;Clinical;Clinical Trials;cohort;Corpus striatum structure;cranium;Data;Dementia;Development;Devices;Dose;Dose Rate;Drug Delivery Systems;Drug or chemical Tissue Distribution;Drug Targeting;Evaluation;expectation;fluid flow;Frontotemporal Dementia;gene therapy;Grant;Histologic;Histology;Image;imaging study;implantable device;improved outcome;Infusion procedures;insight;interest;Intraventricular;Knowledge;Learning;Legal patent;Link;Maintenance;Malignant neoplasm of brain;Measures;Medical Device;Messenger RNA;Methotrexate;Monitor;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neuromuscular Junction;Neuronal Plasticity;Neurons;new technology;novel;novel therapeutics;Operative Surgical Procedures;patient safety;Patient-Focused Outcomes;Patients;Penetration;Pharmaceutical Preparations;Pharmacologic Substance;Phase;phase 1 study;phase II trial;Physiological;Pilot Projects;pre-clinical;precision drugs;pressure;Process;protein TDP-43;Pump;Regulation;repaired;Research;response;RNA metabolism;RNA Sequences;RNA Splicing;Safety;safety and feasibility;safety practice;safety study;sensor;Sensory;Sheep;Small Business Innovation Research Grant;stathmin;Structure;Study models;System;Technology;Therapeutic;Therapeutic Uses;Time;Tissue Sample;Tissues;Titrations;United States National Institutes of Health;Ventricular;Work

PROJECT_TITLE: Targeted Cerebral Spinal Fluid (CSF) Drug Delivery - Enclear Precision System

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-G (13)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Inorganic arsenic is an environmentally ubiquitous toxin that affects >100 million people worldwide, with health consequences ranging from acute toxicity to cancer. We discovered that arsenic exposure disrupts a key protein and three-dimensional (3-D) structure of the genome via novel “circular RNA” regulatory mechanism, thereby altering normal gene expression and cellular activity. In this project, we will define the molecular mechanism and prove that the arsenic-induced “circular RNA” regulatory switch is responsible for disease.

PI_NAMEs: FONDUFE-MITTENDORF, YVONNE NSOKIKA (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: 3-Dimensional;acute toxicity;Affect;Animal Model;Architecture;Arsenic;arsenic carcinogenesis;arsenic-induced carcinogenesis;ATAC-seq;Binding;Binding Sites;Biological Assay;Biology;carcinogenesis;carcinogenicity;Caspase;Cell Differentiation process;Cell Line;Cell model;cell type;Cells;Chromatin;Chromatin Structure;circular RNA;Code;Compensation;Data;Diagnostic;Disease;Distal;DNA;DNA Binding;DNA Binding Domain;DNA Damage;DNA lesion;DNA Methylation;Environment;Epigenetic Process;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Genome;genome-wide;Health;Higher Order Chromatin Structure;Histones;in vitro Model;Link;Malignant Neoplasms;Mediating;Messenger RNA;MicroRNAs;Modeling;Molecular;mRNA Transcript Degradation;Mutate;Neoplasm Metastasis;novel;Nuclear;Nuclear Matrix;Oligonucleotides;Oncogenes;overexpression;Pathway interactions;Peptides;Persons;Play;Porifera;Post-Translational Protein Processing;posttranscriptional;Process;Production;programs;Protein Isoforms;Proteins;Reactive Oxygen Species;Regulation;RNA;Role;Signal Transduction;Site;Structure;targeted treatment;Testing;Toxin;transcriptome sequencing;Translating;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;Untranslated RNA

PROJECT_TITLE: circSATB2, a novel regulator of arsenic-induced carcinogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-Y (04)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: SUNNYSIDE

ORG_NAME: BELLAGE, INC.

ORG_STATE: NY

PHR: PROJECT NARRATIVE The Adult Wellbeing CheckUp (AWC) platform will facilitate wellbeing assessments, referrals, and recommendations of American adults over 65 years of age to age well. AWC leverages an existing wellbeing assessment with probing questions to deliver personalized recommendations and behavior change principles to support the aging network. By personalizing to the context of an individual’s life and utilizing evidence-based behavior change principles, the platform will encourage older adults to take actions to improve their individual and overall wellbeing domains. AWC’s initial customers includes government- and privately-funded organizations and programs, healthcare platforms, and older adults.

PI_NAMEs: FIRMAN, JAMES P (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Adult;African American;Age;Age Years;Aging;Alzheimer's disease related dementia;American;Area;base;behavior change;Caregivers;Caring;checkup examination;Chronic Disease;Collaborations;commercialization;Communication;Communities;Confusion;contextual factors;Country;County;COVID-19;Data Collection;design;Development;Dimensions;Disease;Doctor of Philosophy;education resources;Enrollment;evidence base;evidence based guidelines;experience;Expert Systems;Face;falls;Functional disorder;Funding;Future;Goals;Government;Health;health assessment;Health Personnel;Health Planning Organizations;Health Services;Healthcare;human old age (65+);Hybrids;improved;Individual;innovation;interest;Internet;Intervention;Interview;Investigation;Knowledge;Latino;Letters;Life;Loneliness;Marketing;Measurement;Measures;Mental Health;Methodology;Motivation;older adult;Participant;Patient Self-Report;peer support;Personal Satisfaction;Persons;Phase;physical conditioning;pilot test;preference;Preventive care;Principal Investigator;Privatization;product development;programs;prototype;Psyche structure;Publications;Randomized, Controlled Trials;Recommendation;Recording of previous events;Research;Resources;Review Literature;Risk;Sampling;Self Efficacy;Services;Site;Small Business Innovation Research Grant;social;social cognitive theory;Social Work;Source;System;Technology;theories;Time;tool;Trees;trend;usability;Washington;web platform;web services;Work

PROJECT_TITLE: Innovative web-based service platform called Adult Wellbeing CheckUp (AWC) to assess older adults  wellbeing, obtain evidence-based recommendations, and receive support to take action


NIH_SPENDING_CATS: Bioengineering;Digestive Diseases;Hematology;Liver Disease;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: ROCHESTER

ORG_NAME: SERSENSE, INC.

ORG_STATE: MN

PHR: NARRATIVE Pre-term birth babies are typically at greater risks of infections, hyperbilirubinemia and hypoglycemia. At the present time, there is a dearth of volume-sparing technologies for blood analysis which places neonates at risk of blood loss and anemia. The objective of this small business grant application is to develop a volume- sparing technology that will utilize 100 times less blood for analysis compared to gold standard approaches.

PI_NAMEs: GONZALEZ-SUAREZ, ALAN M (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Aliquot;Anemia;Antibodies;Applications Grants;Bilirubin;Biochemical;Biological Assay;Biological Markers;Blood;Blood Volume;Businesses;C-reactive protein;Calcium ion;Clinical;Color;cytokine;Cytomegalovirus;Detection;Devices;Drops;Electrodes;Future;Glucose;Hemorrhage;Hyperbilirubinemia;Hypoglycemia;Iatrogenesis;Icterus;Immunoassay;Individual;Infant;Infection;infection risk;Inflammatory;laboratory equipment;Left;manufacture;Measurement;meter;Microfluidic Microchips;Monitor;nanoGold;Neonatal;neonatal health;Neonatal Intensive Care Units;neonate;operation;Optics;Oxidation-Reduction;Packed Red Blood Cell Transfusion;Patients;Phase;Plasma;point of care;potassium ion;Premature Birth;Premature Infant;prototype;Reagent;Reference Values;Reporter;research clinical testing;Risk;Sampling;Sepsis;Silicone Elastomers;Small Business Technology Transfer Research;Specimen;System;Technology;technology platform;Testing;Time;Transfusion;Validation;Whole Blood

PROJECT_TITLE: Automated microfluidic device for blood analysis in neonates

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-S (12)]


ORG_CITY: Waltham

ORG_NAME: LASE INNOVATION INC.

PHR: Narrative This application will lead to commercialization of a new technology with immediate benefits for life science research by addressing the current challenge of obtaining comprehensive information from individual cells. This advancement will accelerate biological discoveries in areas such as cancer, immunology, and stem cell biology.

PI_NAMEs: KWOK, SHELDON J.J. (contact)

PROJECT_TERMS: Acceleration;Address;Adopted;Area;Bar Codes;Basic Science;Behavior;Biological;Biological Sciences;biological systems;biomaterial compatibility;Businesses;cancer cell;cell behavior;Cell Physiology;Cell Separation;Cells;cellular imaging;commercialization;complex biological systems;Computational algorithm;Computer software;Data;Data Set;Development;DNA;DNA Sequence;drug discovery;fabrication;fluorescence microscope;Fluorescent in Situ Hybridization;Gene Expression Profile;General Hospitals;Genetic;Genomics;Goals;Image;Immunology;in situ imaging;Individual;innovative technologies;insight;interest;Lasers;live cell imaging;Long-Term Effects;Malignant Neoplasms;Massachusetts;Methods;Microscope;microscopic imaging;Molecular;Molecular Profiling;multidimensional data;Neurobiology;new technology;novel;Oligonucleotides;optical emission;optical spectra;Optics;Outcome;particle;Phase;Pilot Projects;Population;Pump;Research;Research Personnel;Resolution;response;Risk;Sampling;scale up;Scientist;single cell analysis;single cell sequencing;Slide;Small Business Innovation Research Grant;spatiotemporal;stem cell biology;Stimulus;success;Techniques;Technology;technology validation;Testing;Time;tool;Triplet Multiple Birth

PROJECT_TITLE: DNA-optical barcoding technology for spatiotemporal single-cell analysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-G (15)]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Climate-Related Exposures and Conditions;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Prevention;Pulmonary Fibrosis;Rural Health;Social Determinants of Health

ORG_CITY: OMAHA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE This project will utilize an immunometabolic approach, with emphasis on the ACOD1-itaconate axis, to describe the biologic mechanisms underpinning environmental exposure-induced inflammatory lung disease, and potentially inform novel therapeutic approaches to hasten lung recovery post- inflammatory bioaerosol exposure.

PI_NAMEs: SCHWAB, AARON  (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Aconitic Acid;aerosolized;Agriculture;airway inflammation;anthropogenesis;Anti-Inflammatory Agents;Antigen Presentation;antimicrobial;Asthma;Biological;Biological Products;Carboxy-Lyases;Characteristics;Chronic Bronchitis;Chronic Disease;Chronic lung disease;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;climate change;Collection;Complex;Data;Development;Disease;Disparity population;Dose;Dust;Endotoxins;environmental agent;Environmental Exposure;Environmental Hazards;Exhibits;Exposure to;Extrinsic allergic alveolitis;Fibrosis;Food production;Formulation;Fungal Components;Gene Expression;Gene Silencing;Goals;Gram-Negative Bacteria;Harvest;Human;immunogenic;Impairment;in vivo;Industrialization;Inflammation;Inflammation Mediators;Inflammatory;inflammatory lung disease;Inflammatory Response;Inhalation;Inhalation Exposure;Knowledge;lens;Lipopolysaccharides;Lung;Lung Diseases;Lung infections;lung injury;lung repair;Macrophage;Macrophage Activation;Malignant neoplasm of lung;Mediating;Mediator;Membrane;Metabolic;microbial;Modality;Modeling;monocyte;mouse model;Mus;Myeloid Cells;novel strategies;novel therapeutic intervention;novel therapeutics;Occupational;Outcome;Oxidative Stress;particle;Particulate Matter;Pathogenesis;Pathway interactions;Phenotype;pre-clinical;prevent;Process;Production;Pulmonary Fibrosis;Pulmonary Inflammation;Recovery;recruit;Recycling;Resolution;respiratory health;response;Risk;Role;rural area;Sepsis;Signal Pathway;single-cell RNA sequencing;targeted delivery;Testing;Therapeutic;Time;Tissues;transcriptome sequencing;transcriptomics;urban area;Vulnerable Populations;waste treatment;Workplace

PROJECT_TITLE: Targeting the ACOD1 immunometabolic pathway of lung myeloid cells to reduce environmental exposure-induced lung disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Cardiovascular;Caregiving Research;Clinical Research;Complementary and Integrative Health;Dementia;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: Brooklyn

ORG_NAME: AUTOTUNE ME LLC

PHR: Project Narrative Despite the promise of music and technology-based interventions, there lack mobile applications that are specifically designed for use by caregivers of individuals with ADRD and currently there is no device available that will provide immediate relief with the proper dose of music for agitation or apathetic behaviors accompanied by ADRD. A mobile application will be created specifically for the use by people with ADRD supported by their family caregivers to detect heart rate and movement and will be prompted to trigger auto-play of songs, titrating dose based on physiological reactions. It is expected that the proposed application will extend the evidence-based benefits of music in millions of homes for people living with ADRD as a therapeutic by reducing agitation and depression symptoms, which remain a burden for both individuals with ADRD and their family caregivers.

PI_NAMEs: ATASHZAR, SEYED FAROKH ;RAY, KENDRA  (contact)

PROGRAM_OFFICER_NAME: HORGUSLUOGLU, EMRIN U

PROJECT_TERMS: Advisory Committees;Aging;Agitation;Algorithms;Alzheimer's disease related dementia;Behavior;Calibration;Caregivers;caregiving;Caring;Characteristics;clinical efficacy;combat;Communities;Data;dementia caregiving;depressive symptoms;design;Detection;Development;Devices;digital;Dimensions;Distress;Dose;E-learning;Equilibrium;evidence base;experience;Family Caregiver;family caregiving;Feedback;Focus Groups;Formal caregiver;Future;heart motion;Heart Rate;Home;improved;Individual;individual response;informal care;Institution;Intervention;Interview;learned behavior;Learning;loved ones;Machine Learning;Measurement;Measures;Mental Depression;mobile application;mood regulation;Movement;Music;Music Therapy;Nerve;neurological rehabilitation;neuropsychiatric symptom;older adult;Participant;Pattern;Perception;Performance;Persons;pharmacologic;Phase;phase 2 study;Physiologic pulse;Physiological;Pilot Projects;Play;preempt;prevent;programs;prototype;Questionnaires;Reaction;recruit;Relaxation;Reporting;Research;Resources;response;satisfaction;sedentary;sedentary lifestyle;Signal Transduction;smart watch;Social Workers;Specificity;Stream;Structure;Suggestion;Surveys;Symptoms;System;Technology;technology intervention;Testing;Therapeutic;therapeutic target;Time;Titrations;United States;usability;Validation;wearable device

PROJECT_TITLE: Developing a therapeutic, music-based mobile application to combat neuropsychiatric symptoms in people living with Alzheimer's disease and related dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-C (10)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Congenital heart defects are present in 1.8% of newborns and account for one third of congenital defects, yet 80% of cases have no identifiable causes. This project proposes a high-resolution in vivo imaging approach for quantitative blood flow analysis in the early mouse embryonic cardiovascular system to build the first dynamic volumetric cardiac flow pattern in early embryos, set a platform for functional cardiovascular phenotyping, and study the biomechanical forces that regulate cardiac development. This will provide valuable insight to the role of blood flow in regulating cardiovascular development and allow investigation into the interplay between genetic and biomechanical factors in cardiac development and disease.

PI_NAMEs: MCCOWN, MICHAELA ANNE (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: 3-Dimensional;Algorithms;Angiography;Area;Biology;Biomechanics;Blood;Blood Cells;Blood Circulation;Blood flow;Blood Vessels;Calibration;Cardiac;cardiogenesis;Cardiovascular system;career;cell motility;Cells;Circulation;Complement;Complex;Computing Methodologies;Congenital Abnormality;congenital heart abnormality;Congenital Heart Defects;Custom;Data;Development;Diagnostic;Dissection;Early treatment;Embryo;Embryonic Cardiovascular System;Embryonic Heart;Fellowship;frontier;Genetic;Heart;Heart Diseases;heart function;heart imaging;Human;Image;image processing;imaging approach;imaging system;in vivo imaging;Individual;insight;Investigation;Maps;Measurement;Measures;Methods;microangiography;Microfluidics;Motion;mouse model;Movement;Mus;Newborn Infant;Noise;novel;Nutrient;operation;Optical Coherence Tomography;Optics;oxygen transport;particle;Particle Size;Pattern;Periodicity;Phase;Phenotype;Predisposition;prevent;Prevention;Procedures;Protocols documentation;reconstruction;Research;Research Personnel;Resolution;Role;Scanning;Signal Transduction;skills;Speed;statistics;Structure;Suspensions;System;Techniques;temporal measurement;Testing;Time;Tissues;Training;Validation;Visualization;wasting;Work

PROJECT_TITLE: Quantitative OCT angiography toward 4D blood flow analysis in embryonic cardiovascular system

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-D (20)]


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE This study seeks to determine the role of endothelial cell cytochrome b5 reductase 1 (CYB5R1) and its role in modulating ferroptosis. The outcomes of these studies may fill a major void in our understanding of the role of CYB5R1 in vascular physiology and disease, with the potential for the development of new strategies and therapeutics to reduce the burden of cardiovascular disease.

PI_NAMEs: HALL, ROBERT  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Aorta;Basic Science;Binding;Biochemical;Biological Assay;Biology;Biomedical Research;Blood Vessels;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;career;career development;Cell Death;Cell Physiology;Cell Survival;Chemicals;Coenzyme A;Coupled;cytochrome b5 reductase;Data;Development;Development Plans;Disease;Doctor of Philosophy;doctoral student;Electron Microscopy;Endothelial Cells;Endothelium;Environment;Enzymes;Equilibrium;experience;Fluorescence Microscopy;Fostering;Functional disorder;Genes;Genetic;Genomics;glutathione peroxidase;Goals;Human;Hydrogen Peroxide;Impairment;Individual;inhibitor;Iron;knock-down;Knockout Mice;Lead;Lipid Peroxidation;Lipid Peroxides;Lipids;Mass Spectrum Analysis;Mediating;medical schools;Membrane;Membrane Lipids;Mentors;Mentorship;Mesenteric Arteries;Mitochondria;Molecular;Molecular and Cellular Biology;Morphology;Myography;novel;Outcome Study;Outer Mitochondrial Membrane;overexpression;Oxidants;Oxidation-Reduction;Pathway Analysis;peroxidation;pharmacologic;Pharmacology;Physiological;Physiology;Pilot Projects;Polyunsaturated Fatty Acids;Positioning Attribute;pre-doctoral;prevent;Process;programs;Proteins;Regulation;Relaxation;Research Personnel;Resources;Role;Signal Transduction;skills;Smooth Muscle Myocytes;supportive environment;Techniques;Technology;Testing;Therapeutic;therapeutic development;Training;translational impact;Ubiquinone;Universities;Vascular Diseases;Vitamin E

PROJECT_TITLE: Discerning the mechanisms of CYB5R1 regulation of ferroptosis in endothelial cells


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Although significantly understudied, neuraminidase is a potential component for a universal influenza vaccine, as antibodies raised against its conserved sites are protective against circulating influenza subtypes and those of pandemic potential (e.g., H5, H7). Here we propose structure-guided neuraminidase immunogens to immune- focus toward the conserved catalytic site on neuraminidase as well as experiments to understand how influenza evolves in response to focused anti-neuraminidase immunity. This work will inform next-generation influenza vaccines and guide general strategies to elicit cross-reactive humoral protection against rapidly evolving pathogens.

PI_NAMEs: HECHT, ROCHEL  (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: Amino Acids;anti-influenza;Antibodies;Antibody Response;Antigens;Avidity;B cell repertoire;B-Cell Activation;B-Lymphocytes;Binding;Binding Sites;Biochemical;Biological Assay;Catalytic Domain;Complement;Complex;Computer Analysis;Coupling;cross reactivity;Data;design;Effectiveness;Engineering;Epitopes;Escape Mutant;Evolution;experimental study;Ferritin;flexibility;global health;Growth;Hemagglutinin;Immune;Immune response;Immunity;In Vitro;in vivo;Infection;Influenza;influenza virus strain;influenza virus vaccine;influenzavirus;interest;Kinetics;Link;lumazine;Masks;Measures;Membrane Glycoproteins;Memory B-Lymphocyte;Molecular Conformation;monomer;mouse model;mutant;Mutation;nanoparticle;Neuraminidase;new pandemic;next generation;non-Native;novel vaccines;pandemic potential;pathogen;Pathway interactions;Point Mutation;Polysaccharides;pressure;prevent;Proteins;rational design;receptor binding;release of sequestered calcium ion into cytoplasm;response;Role;scaffold;Serum;Sialic Acids;Site;Structure;Structure of germinal center of lymph node;Surface;Testing;universal influenza vaccine;Vaccine Design;vaccine-induced immunity;Vaccines;Viral;Virion;Virus;Work

PROJECT_TITLE: Structure-based design of neuraminidase immunogens for next-generation influenza vaccines

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-S (20)]


ORG_CITY: SYKESVILLE

ORG_NAME: ZETEO TECH, INC.

PHR: The overall goal of this proposed effort is to develop a mass spectrometry-based system for rapid and accurate analysis of antibodies and related macromolecular immune complexes.

PI_NAMEs: BERKOUT, VADYM D (contact)

PROGRAM_OFFICER_NAME: BILLINGSLEA, EDDIE

PROJECT_TERMS: Acceleration;Affinity;Antibodies;antibody conjugate;Antigen-Antibody Complex;Binding;Biological Sciences;Charge;commercial application;Complex;Consumption;cost;Cost Analysis;cryogenics;Data;design;Detection;detector;Electrospray Ionization;Event;Floor;Future;Goals;Health;Heterogeneity;High temperature of physical object;innovation;interest;ion source;ionization;ionization technique;Ions;Ligand Binding;Ligands;mass analyzer;mass spectrometer;Mass Spectrum Analysis;Measures;models and simulation;nanowire;Noise;novel;operation;Optics;Phase;Proteins;Research Personnel;Sampling;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;stoichiometry;Structure;System;Techniques;Technology;Temperature;Time;Update;Virus;voltage

PROJECT_TITLE: High Mass MALDI TOF Employing a Novel High-Tc Superconducting Ion Detector


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Rare Diseases

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

PHR: PROJECT NARRATIVE Maternal-child synchrony describes the ways in which mothers and children impact each other’s social and physiological states, it lays critical groundwork for children’s social development, and it is impacted by contextual factors. Children with fragile X syndrome (FXS) are particularly vulnerable to having disrupted maternal-child respiratory sinus arrythmia (RSA; a marker of cardiac functioning) synchrony due to 1) children with FXS and their mothers experiencing atypical RSA functioning, 2) mothers of children with FXS experiencing elevated mental health challenges, and 3) the clinical status of children with FXS, yet the role of maternal-child RSA synchrony in FXS has not yet been examined and the impact of contextual factors on this RSA synchrony has been neglected. Therefore, this proposed study will investigate the role of contextual factors on maternal-child RSA synchrony in FXS during infancy.

PI_NAMEs: HANTMAN, RACHEL  (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Adolescent;Affect;Age Months;Anxiety;Arousal;Attention;autism spectrum disorder;Autonomic nervous system;Behavior;Behavioral;biobehavior;Cardiac;CGG repeat;Child;Child Development;Childhood;Clinical;Cognitive;Complex;contextual factors;Depressed mood;Development;disability;Disease;emotion regulation;experience;Family;Family Relationship;FMR1 gene;FMR1 Premutation;Fragile X Premutation;Fragile X Syndrome;Functional disorder;Future;gaze;Genetic Diseases;Heart;heart function;Heart Rate;Hereditary Disease;Heritability;Hydrocortisone;Impairment;improved;indexing;Individual;infancy;Infant;Informal Social Control;Intellectual functioning disability;Knowledge;Language;lens;Life;Literature;male;Mental Depression;Mental Health;Methods;Mother-Child Relations;Mothers;mutation carrier;neglect;Neurodevelopmental Disorder;Outcome;Phenotype;Physiological;Physiology;Play;Populations at Risk;Predisposition;Pregnancy;premature;Publishing;Research;Resources;respiratory;response;Risk;Role;Sampling;Sinus;Sinus Arrhythmia;social;social deficits;Social Development;social engagement;Standardization;Stress;Subgroup;System;theory of mind;Voice;Woman;Work

PROJECT_TITLE: Maternal-Child RSA Synchrony in Infants with Fragile X Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]