NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Human Genome

PI_NAMEs: MEI, HAO  (contact)

PROJECT_TERMS: Address;Algorithms;analysis pipeline;Applications Grants;Bioinformatics;Biological;Biometry;Body System;cell type;Cells;Complex;Computational Biology;Consultations;Custom;Data;Data Collection;data integration;Data Science;Data Set;database design;Dedications;Disease;Education;education planning;Educational workshop;Ensure;Epigenetic Process;epigenomics;Event;Experimental Designs;Extramural Activities;Faculty;Functional disorder;Genes;Genetic Predisposition to Disease;Genomics;Goals;Health;High Performance Computing;human subject;improved;Individual;Infrastructure;innovation;insight;Leadership;Manuscripts;Maps;Medical center;meetings;Mentors;Mentorship;metabolomics;Methodology;Mission;Mississippi;Molecular;multidisciplinary;novel;novel strategies;Onset of illness;Organ;Organism;Performance;Phase;Physiological;Physiology;Pilot Projects;population health;power analysis;Preparation;Program Description;programs;Proteomics;Reporting;Reproducibility;Research;Research Personnel;Schools;service delivery;Services;Statistical Data Interpretation;Statistical Models;Students;success;Systems Biology;Systems Development;Technical Expertise;technological innovation;Technology;Tissues;Training;Training and Education;training opportunity;transcriptomics;Universities;Variant

PROJECT_TITLE: Core C-Research Computing, Bioinformatics, and Biostatistics


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cerebrovascular;Dementia;Estrogen;Genetics;Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: JACKSON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Narrative Currently, there is a lack of knowledge of sex-specific mechanisms in menopause-related cerebrovascular  dysfunction and vascular cognitive impairment. This proposal attempts to understand and intervene in sex-specific mechanisms to reduce cerebrovascular dysfunction in post-menopausal old females.

PI_NAMEs: GARRETT, MICHAEL R (contact)

PROJECT_TERMS: Address;Adverse effects;aged;Animals;antioxidant enzyme;Antioxidants;Bioinformatics;Blood Vessels;Brain;Cell Line;Centers of Research Excellence;cerebral artery;Cerebral Ischemia;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrovascular system;Cerebrum;Chronic;cognitive function;comparison control;Contracts;Core-Binding Factor;Data;Development;Disease;Down-Regulation;Erythroid;Estradiol;Evaluation;Event;Exhibits;Female;female sex hormone;Genes;Genetic;genome-wide;genomic data;Health;hormone therapy;Hormone use;Impaired cognition;improved;Incidence;Infarction;insight;Ion Channel;Ischemia;Ischemic Stroke;Knock-out;Knowledge;large-conductance calcium-activated potassium channels;Mediating;Menopause;middle cerebral artery;Molecular;new therapeutic target;novel;Nuclear;Ovariectomy;Pathway interactions;Perfusion;pharmacologic;Pharmacological Treatment;Physiological;post stroke;Postmenopause;Potassium Channel;Predisposition;pressure;Property;protein expression;Proteomics;Rattus;Reactive Oxygen Species;Regulation;Reperfusion Injury;Reperfusion Therapy;Resources;response;Risk;Risk Reduction;Role;Severities;sex;Stroke;stroke risk;Supplementation;Testing;therapeutic target;Therapeutically Targetable;transcription factor;transcriptome;transcriptomic profiling;Up-Regulation;Validation;Vascular Cognitive Impairment;Vasodilation;Woman

PROJECT_TITLE: Project 1 - TBD


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Sleep Research

PHR: Project Narrative The proposed studies will use a combination of cutting-edge molecular approaches with transgenic mice, together with complementary human postmortem studies, to create a much-needed foundation of molecular signaling pathways involved in regulating signaling in the brain associated with fear memory during sleep and identify new molecules involved in this process. The expected data will serve as a foundation for future studies examining disruption of these pathways in psychiatric disorders, and studies designed to identify novel targets for therapeutic strategies.

PI_NAMEs: GISABELLA, BARBARA  (contact)

PROJECT_TERMS: Address;Affect;Amygdaloid structure;Area;Autopsy;Brain;Candidate Disease Gene;Cell Nucleus;Cell Separation;cell type;Cells;Centers of Research Excellence;Cessation of life;circadian;conditioned fear;Data;Databases;Dendritic Spines;Disease;Diurnal Rhythm;Emotional;Euthanasia;fear memory;Foundations;Fright;Future;Gene Expression;Genes;Health;Hippocampus;Hour;Human;Immunofluorescence Immunologic;improved;Knowledge;Label;Learning;Maps;Mass Spectrum Analysis;Mediating;Memory;memory consolidation;Memory impairment;Mental disorders;Molecular;Molecular Profiling;mouse model;Mus;Neurons;neuropsychiatric disorder;new therapeutic target;next generation;Nightmare;Noise;novel;Pathway interactions;Patients;Persons;Population;Post-Traumatic Stress Disorders;Process;Proteomics;Publishing;Quality of life;Regulation;Research Design;Rodent;Role;Sampling;Schizophrenia;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Sleep;Sleep Disorders;Sleep disturbances;sleep spindle;Spermidine;Stimulus;Symptoms;Synapses;Technology;Testing;theories;Time;transcriptome sequencing;transcriptomics;Transgenic Mice;vector;Viral;Viral Vector;Wakefulness

PROJECT_TITLE: Molecular Mechanisms of Memory Consolidation in the Amygdala-Hippocampal Circuit


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Disability Research;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSURGERY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative Malformations of brain development lead to mental retardation, epilepsy, neurological deficiencies and life-long learning, cognitive and motor disabilities. The experiments proposed in this grant will greatly contribute to understanding how brain growth is regulated through the comprehensive analysis of the molecular mechanisms controlling neuronal differentiation during brain development. Completion of the experiments described in this application will lead to a better understanding of brain disorders such as microcephaly and will allow us to better diagnose, predict and possibly envision future avenues for therapeutic intervention.

PI_NAMEs: DAHMANE, NADIA  (contact);GARCIA, BENJAMIN A

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Acetylation;Adult;Affect;ATAC-seq;Binding;Brain;Brain Diseases;brain malformation;Brain region;Catalytic Domain;Cell Differentiation process;Cell Fate Control;Cell Lineage;Cell Separation;cell type;Cells;Cerebellum;ChIP-seq;Chromatin;Chromatin Remodeling Factor;Co-Immunoprecipitations;cognitive disability;Collaborations;Complex;Corpus Callosum;Coupled;Data;Defect;Development;Developmental Biology;developmental neurobiology;Diagnosis;DNA Binding;Embryo;Epigenetic Process;epigenetic regulation;Epilepsy;experimental study;Future;Gene Expression;gene repression;Gene Targeting;Genes;Genetic;Genetic Markers;Genetic Transcription;Global Change;Grant;Growth;Histones;Human;Immunoprecipitation;In Vitro;in vivo;insight;Intellectual functioning disability;Lead;Learning Disabilities;Life;Lifelong disability;Link;loss of function;Maintenance;Malignant neoplasm of brain;Maps;Mass Spectrum Analysis;Medicine;member;Mental Retardation;Methylation;Microcephaly;Molecular Analysis;Motor disability;mouse genetics;Mus;Mutation;Neocortex;Nervous System Disorder;Neurodegenerative Disorders;neurogenesis;Neurologic;Neuronal Differentiation;Neurons;Nucleosomes;Pennsylvania;Polycomb;Post-Translational Protein Processing;postmitotic;postnatal;Process;progenitor;programs;protein protein interaction;Proteins;Proteomics;Regulation;Schizophrenia;stem cell proliferation;SWI/SNF Family Complex;Testing;Therapeutic Intervention;Tissues;transcription factor;transcriptome;Universities;Western Blotting;Zinc Fingers

PROJECT_TITLE: A Mass Spectrometry Approach to the Genetic and Epigenetic Mechanisms Controlling Neuronal Identity


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Burden of Illness;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Food Allergies;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Nutrition;Prevention;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: RELEVANCE (See instructions):  Studies proposed under this grant are directly relevant to understanding allergic diseases in general and  specifically in relation to the α-gal syndrome a novel form of food allergy that we became aware of in  2007. Studies are designed to improve our understanding of the clinical features, the treatment and the  immunology of this syndrome. We will extend our understanding of why this syndrome which relates to  tick bites has increased in the United States and further understand the gastrointestinal and cardiac risks.

PI_NAMEs: PLATTS-MILLS, THOMAS A. (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Abdomen;Address;Adult;Allergens;Allergic;Allergic Disease;Allergic Reaction;alpha-gal syndrome;Amblyomma;Ambylomma americanum;Anaphylaxis;Antibodies;Antigens;Antivenins;Area;Australia;Awareness;B-Lymphocytes;Basophils;Biological Assay;Bite;Blinded;blood group;Blood typing procedure;Cardiac;Cardiology;Cattle;Circulation;climate change;Clinic;Clinical;Clinical Management;cohort;Collaborations;Communities;Coronary Angiography;Coronary Arteriosclerosis;Country;Cross-Over Studies;Data;Data Analyses;Defect;design;Diet;Disease;Eating;Enrollment;Eosinophilic Esophagitis;Epidemiology;Epitopes;Esophagus;follow-up;Food;Food Hypersensitivity;Frequencies;galactosyl-(1-3)galactose;gastrointestinal;Geographic Distribution;Glycolipids;Glycoproteins;Goals;Grant;Health;Heparin;High-Throughput DNA Sequencing;Human;Hypersensitivity;IgE;Immune response;Immunoglobulins;Immunologics;Immunology;improved;in vivo;Incidence;infancy;Inflammatory;Ingestion;Instruction;Investigation;Irritable Bowel Syndrome;Kinetics;Knock-out;Link;Lipoproteins;Mammals;Mass Spectrum Analysis;Measurement;Measures;Meat;Mediating;Mediator;Medicine;meetings;Milk;Monoclonal Antibodies;Nature;North Carolina;novel;Oligosaccharides;Oral Ingestion;participant enrollment;particle;Patient Selection;patient subsets;Patients;Placebo Control;Placebos;Polysaccharides;Population;Prevalence;prospective;Publications;Reaction;Reagent;Recording of previous events;recruit;Reporting;Research;response;Risk;Serology;Severities;Site;Skin;Solenopsis invicta;Source;Surveys;Symptoms;Syndrome;T cell response;T-Lymphocyte;technique development;tick bite;Ticks;time interval;tool;United States;Urticaria;Variant;Virginia;Visit;Work

PROJECT_TITLE: IgE antibodies to the mammalian oligosaccharide galactose-alpha-1, 3-galactose (alpha-gal): immunology, epidemiology and relevance to allergic and inflammatory disease

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Our overarching goals are to develop statistical methods for the analysis of imaging acquired on multiple scanners for the study of multiple sclerosis (MS). We will develop and validate statistical methods for identifying individual lesions and quantifying the central vein in MS lesions for improved MS diagnostics as well as techniques for automatically identifying lesion phenotypes in a novel coordinate system. Finally, we will develop methods that allow for the study of patterns of neuropathological change across an image to study diffuse changes in the normal-appearing white and gray matter of the brain.

PI_NAMEs: SHINOHARA, RUSSELL TAKESHI (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Adoption;analysis pipeline;automated analysis;Biological Markers;Biological Process;Blood Vessels;Brain;burden of illness;Central Vein;Chronic;Clinic;Clinical;clinical decision-making;clinical practice;Clinical Research;clinically relevant;Data;density;Detection;detection method;Development;Diagnosis;Diagnostic;diagnostic accuracy;Diffuse;disability;Disease;Disease Progression;education resources;Etiology;Functional disorder;Future;Goals;gray matter;Heterogeneity;Histopathology;Horns;illness length;Image;Image Analysis;imaging biomarker;imaging study;improved;indexing;Individual;individual patient;infancy;ischemic lesion;Lesion;Location;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Methods;Microglia;Monitor;Morphology;Multimodal Imaging;multimodality;multiparametric imaging;Multiple Sclerosis;Multiple Sclerosis Lesions;Myelin;neuroimaging;Neurologist;neuropathology;novel;older patient;Outcome;Pathology;Patients;Pattern;Phase;Phenotype;precision medicine;Predisposition;Process;radiologist;radiomics;repaired;Research;research study;Sequence Analysis;Severities;Signal Transduction;software development;Statistical Data Interpretation;Statistical Methods;statistics;stem;System;T2 weighted imaging;targeted treatment;Techniques;Therapeutic;Time;tissue injury;tissue repair;Tissues;tool;Translating;Translations;Validation;Ventricular;Visit;Visual;white matter;Work

PROJECT_TITLE: Advanced Statistical Analytics of MRI in MS

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dietary Supplements;Genetics;Human Genome;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The public health relevance of our study is two-fold: 1) Premature aging and lower healthy life expectancy disproportionately affect people in resource-limited environments; and 2) We assess the roles of a modifiable risk factor (nutritional supplementation) in early life, which could represent actionable changes to improve DNA- related mechanistic pathways closely linked with physiologic aging. Our expected findings could shed light on novel nutrition-sensitive biomarkers of physiologic aging that persistent reflect the early-life exposome into adulthood, leading to improved prevention of premature aging and related consequences over the life course.

PI_NAMEs: STEIN, ARYEH DAVID (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: 2 year old;3 year old;Address;Adult;adverse outcome;Affect;Age;Age Months;Age Years;Aging;aging related;Anthropometry;Biological Aging;Biological Assay;Biological Markers;Body mass index;candidate marker;Central America;Cessation of life;Child;Child Malnutrition;China;Chronology;cohort;Collaborations;Conceptions;Country;Data Collection;design;Development;Diabetes Mellitus;diabetes risk;Diet;Dietary Intervention;Disease;DNA;DNA Methylation;early childhood;early-life nutrition;effectiveness evaluation;Enrollment;Environment;Epigenetic age;epigenetic clock;Epigenetic Process;epigenome-wide association studies;experience;Exposure to;Face;Famines;follow-up;Freezing;Goals;Guatemala;hallmarks of aging;Health;healthspan;healthy aging;Height;high body mass index;Human;improved;Incidence;Income;indexing;Individual;Infant;innovation;intergenerational;Intervention;Intervention Trial;late life;Length;Leukocytes;Life;Life Cycle Stages;Life Expectancy;life span;Link;Longitudinal Studies;low and middle-income countries;Malnutrition;Measures;Mendelian randomization;Metabolic;methylation pattern;modifiable risk;multidisciplinary;Netherlands;novel;nutrition;Nutrition Indexes;Nutritional status;Nutritional Study;nutritional supplementation;offspring;Outcome;Panama;Paper;Participant;Pathway interactions;Pattern;Persons;Physiological;Pregnancy;Pregnant Women;premature;Premature aging syndrome;Prenatal Nutrition;prevent;Prevention;Prevention strategy;Productivity;Prospective, cohort study;Proteins;public health relevance;Publishing;Randomized;Recording of previous events;Research;Research Institute;Research Personnel;Resource-limited setting;Risk Factors;Role;Sampling;Site;Strategic Planning;stressor;Subgroup;Supplementation;telomere;Treatment Protocols;United States National Institutes of Health;Universities

PROJECT_TITLE: Adult epigenetics and telomere length in relation to improved nutrition in early life

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Hematology;Neurosciences;Prevention;Rare Diseases;Sickle Cell Disease;Stroke

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE Individuals with profound anemia, particularly sickle cell anemia (SCA), have a high risk of developing strokes and silent cerebral infarcts; this risk begins in early childhood, with more than 50% affected by 30 years of age. Better understanding stroke mechanisms in anemia should improve stroke risk identification, and lead to better treatments to prevent stroke. This study uses multiple hemodynamic and metabolic brain imaging techniques to understand differences in brain blood flow and oxygen use before versus after anemia treatments, as well as how brain blood flow and oxygen utilization differ in anemic individuals with versus without strokes.

PI_NAMEs: DONAHUE, MANUS J (contact);JORDAN, LORI CHAFFIN

PROGRAM_OFFICER_NAME: HARTMAN, ADAM L

PROJECT_TERMS: Acceleration;Acute;Adult;Affect;Aftercare;Age;Age Years;Alzheimer's Disease;Anemia;arterial spin labeling;Benefits and Risks;Biological Markers;biomarker development;Blood;Blood capillaries;Blood Transfusion;Blood Vessels;Brain;brain health;Brain imaging;Cephalic;cerebral autoregulation;cerebral capillary;Cerebral Infarction;Cerebral Ischemia;Cerebrovascular Circulation;Cerebrum;Child;Clinical;clinically relevant;cohort;Compensation;Data;Disease;early childhood;Enrollment;Exclusion;Functional disorder;Genetic;Goals;Health;hemodynamics;Hemoglobin;Hemoglobin concentration result;high risk;Hyperemia;Hypertension;Image;imaging approach;Imaging Techniques;improved;in vivo;Individual;Infarction;innovation;intracranial artery;Ischemia;Ischemic Stroke;Magnetic Resonance Imaging;Measures;Metabolic;Metabolism;Methods;Migraine;Nervous System Trauma;neuroimaging;neurovascular;non-invasive imaging;novel;novel therapeutics;Outcome;Oxygen;Oxygen Consumption;Participant;Patients;Physiologic arteriovenous anastomosis;Physiology;Prevention therapy;Procedures;public health relevance;Publishing;Race;Regression Analysis;Reporting;Reproducibility;Risk;Risk Factors;Scanning;Severity of illness;sex;Sickle Cell Anemia;Signal Transduction;Sinus;stem cell therapy;Stenosis;Stroke;Stroke prevention;stroke risk;Testing;Therapeutic Trials;Time;Tissues;tool;Transfusion;Traumatic Brain Injury;treatment response;Triage;Vascular Diseases;Venous;venous sinus;Work

PROJECT_TITLE: Mechanisms of cerebral infarcts and brain oxygen utilization in anemia


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Neurosciences;Regenerative Medicine;Rehabilitation;Stroke

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Stroke is the leading cause of adult disability in the United States and, outside of physical therapy, no treatments exist to improve recovery of stroke patients. The research proposed in this application seeks to substantially improve our understanding of the way brain circuits and networks repair themselves after stroke. Unmasking these basic mechanisms of stroke recovery could facilitate the development of novel treatments to enhance recovery, reduce disability, and improve the lives of stroke survivors.

PI_NAMEs: ALBERTSON, ASHER JEFFERSON (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acute Brain Injuries;Address;Adult;Automobile Driving;Award;axonal sprouting;Basic Science;Behavioral;Biological Assay;Brain;Brain region;calcium indicator;career;career development;Cerebrum;Clinical;Complement;cortex mapping;Development;Development Plans;disability;Distant;Doctor of Philosophy;effective therapy;Ensure;Environment;experience;Exposure to;Faculty;fluorescence imaging;Follow-Up Studies;Functional Imaging;functional restoration;Future;Gene Transfer;Genetic Engineering;Global Change;Goals;Growth Associated Protein 43;Image;imaging platform;imaging study;improved;improved outcome;Infarction;insight;International;Ischemia;Ischemic Brain Injury;Ischemic Stroke;K-Series Research Career Programs;knock-down;Laboratories;Learning;Maps;Measures;Mediating;Mediator;meetings;Mentors;Mentorship;Molecular;Mus;Neurologist;Neurology;neuronal circuitry;Neurons;neurophysiology;novel;Patient Care;Patients;Physical therapy;Physicians;Physiology;Positioning Attribute;post stroke;Process;Productivity;Proteins;Recovery;Recovery of Function;repaired;Research;Research Personnel;Research Training;responsible research conduct;restoration;Role;role model;Scientist;Sensory;sensory stimulus;skills;small hairpin RNA;somatosensory;Somatosensory Cortex;Stroke;stroke patient;stroke recovery;stroke survivor;Structure;supportive environment;Synapses;Testing;Thalamic structure;Time;Training;Translating;Translational Research;translational study;United States;Viral;Viral Genes;Walking;Work

PROJECT_TITLE: Role of Axonal Sprouting Mediated Network Reorganization in Stroke Recovery

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Hearing Loss;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Hearing difficulties with age may be due to the progressive loss of nerve connections in the inner ear, but this loss does not show up in current clinical tests. The proposed study will integrate research in humans and animals with human-like hearing to develop new diagnostic tests for this ‘hidden’ hearing loss. The completion of this study could lead to novel diagnostic tests that can be used to detect this loss of inner ear nerve connections in the clinic, all while setting up a research pipeline to develop future diagnostics and test therapies for various forms of hearing loss.

PI_NAMEs: PARTHASARATHY, ARAVINDAKSHAN  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acceleration;Acoustic Nerve;Address;Adult;Affect;Age;age effect;age related;age related changes;Age related comorbidities;Age Years;Aging;Anatomy;Animal Experimentation;Animal Model;Animals;ATPase inhibitory protein;Auditory;auditory pathway;Auditory Threshold;Autopsy;Behavioral;Biological Markers;Birth;Clinic;Clinical;Cochlea;cochlear synaptopathy;Code;Communication;Complex;Cues;Data;design;Development;Diagnostic;Diagnostic tests;Dose;efficacy testing;Electrophysiology (science);Exhibits;experience;experimental study;Frequencies;Future;Gerbils;Goals;Hearing;hearing impairment;Hearing problem;hearing range;Hearing Tests;help-seeking behavior;hidden hearing loss;Histologic;Human;human model;Impaired cognition;indexing;Individual;Infusion procedures;Inner Hair Cells;innovation;Intervention;juvenile animal;Labyrinth;Life;Link;Measurement;Measures;Methods;middle age;Nerve;Nerve Fibers;neural;normal hearing;novel diagnostics;older adult;Ouabain;Patients;Performance;Peripheral;Phase;preclinical study;Presbycusis;programs;Quality of life;Research;response;response biomarker;Rodent Model;Role;Specimen;Speech;speech in noise;Speech Intelligibility;Speech Perception;Stimulus;Structure;Synapses;Temporal bone structure;Testing;Therapeutic Intervention;translational approach;Translations

PROJECT_TITLE: Effects of Age-related Cochlear Synaptopathy on Speech-in-noise Intelligibility: A Cross-species Approach

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Disability Research;Hearing Loss

ORG_CITY: ROCHESTER

ORG_DEPT: MISCELLANEOUS

ORG_NAME: ROCHESTER INSTITUTE OF TECHNOLOGY

PHR: Deaf and hard-of-hearing (DHH) scientists constitute a severely underrepresented group in the nation’s biomedical research workforce. The proposed RIT U-RISE Scientists-in-Training Program for Deaf and Hard-of-Hearing Undergraduates will implement an undergraduate research-intensive training program to prepare DHH baccalaureate students in this linguistic and cultural minority for admission into doctoral programs in biomedically related research disciplines. RIT U-RISE will reduce the underrepresentation of DHH scientists in the nation’s biomedical research workforce and, in turn, promote research to reduce the corresponding disparities in DHH people’s health and healthcare.

PI_NAMEs: PANKO, TIFFANY LOIS (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Academic achievement;Adult;Age;Award;Binding;Biomedical Research;cohort;Communication;Communication Barriers;Communities;Community of Practice;cultural competence;curriculum enhancement;Data;deaf;Development Plans;Disincentive;Doctor of Philosophy;Ensure;evidence base;experience;Face;Faculty;Fostering;Graduation Rates;Grant;Gravitation;hard of hearing;Hearing;hearing disability;hearing impairment;Individual;Infrastructure;Institution;Laboratories;Language;Mentors;Mission;Modality;Monitor;Persons;Prevalence;Professional Competence;programs;psychosocial;Reporting;Reproducibility;Research;Research Ethics;Research Training;Resources;role model;Safety;Science;Scientist;Self Efficacy;Services;skills;social stigma;STEM student;Students;success;symposium;Technology;Training;Training Programs;trend;tutoring;undergraduate research experience;undergraduate student;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Rochester Institute of Technology U-RISE Scientists-in-Training Program for Deaf and Hard-of-Hearing Undergraduates (RIT U-RISE)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Kidney Disease;Regenerative Medicine

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Acute kidney injury (AKI) is a significant healthcare problem. Proposed studies will investigate how novel immune checkpoint molecule, TIGIT, regulates mouse and human kidney T cell functions during AKI. This study is crucial for developing safer AKI therapies and reducing adverse kidney effects of current anti-cancer immune checkpoint therapies.

PI_NAMEs: NOEL, SANJEEV  (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Adoptive Transfer;Adverse effects;Agonist;Allografting;antagonist;anti-cancer;Anti-Inflammatory Agents;Antibodies;Antibody Therapy;Apoptosis;Biopsy;Blocking Antibodies;Cancer Patient;cancer therapy;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Physiology;Cell Separation;cell type;Cells;checkpoint therapy;Chronic Kidney Failure;Cisplatin;Clinical;Clinical Research;Clinical Trials;comparison control;CTLA4 gene;cytokine;Cytometry;Data;Dendritic Cells;Development;experimental study;Flow Cytometry;Functional disorder;Future;Gene Expression Profile;Genetic Transcription;Grant;Healthcare;Human;Immune;immune checkpoint;Immune checkpoint inhibitor;Impairment;implantation;In Vitro;in vivo;Inflammatory;Inflammatory Response;Injury;Interleukin-10;Ischemia;ITIM;Kidney;Kidney Diseases;kidney repair;Kidney Transplantation;Knockout Mice;Knowledge;Malignant Neoplasms;Mediating;Modeling;Mus;Natural Killer Cells;Nephrectomy;nephrotoxicity;next generation sequencing;novel;Outcome;Pathogenesis;Pathogenicity;Patients;Phase;Phenotype;Play;preclinical study;preimplantation;Process;Production;Property;Publishing;receptor;Regulatory T-Lymphocyte;Renal Cell Carcinoma;Renal function;repaired;Reperfusion Therapy;response;Rheumatoid Arthritis;Risk;Role;Sampling;Severity of illness;Signal Transduction;single-cell RNA sequencing;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;trafficking;transcriptome sequencing;Transplant Recipients

PROJECT_TITLE: TIGIT in acute kidney injury and repair

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Eye Disease and Disorders of Vision;Genetics

PHR: Project Narrative This project seeks to determine whether the retroelement LINE1 activates the immune system in a way that contributes to autoimmunity in Sjögren’s Syndrome. This work could help explain how dysregulated immune surveillance of endogenous genetic material could promote autoimmunity in some people. Completion of this work may help direct study of new targeted therapies for Sjögren’s Syndrome and related rheumatic diseases.

PI_NAMEs: ANTIOCHOS, BRENDAN  (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Affect;Antibodies;Autoantibodies;Autoantigens;Autoimmune Diseases;Autoimmunity;Autophagocytosis;Award;Binding;Biochemical;Biological Markers;Blood;Burn injury;Cell Line;Cells;Cellular Assay;Characteristics;Complex;Cultured Cells;Cytoplasm;Data;Development;Disease;DNA;ds-DNA;Ductal Epithelial Cell;Epithelial Cells;Filament;Fostering;Future;Generations;genetic element;Genetic Materials;Gland;Grant;Human;human tissue;Hybrids;Immune;immune activation;Immune response;Immune system;Immunologic Surveillance;In Vitro;Inflammatory;Innate Immune Response;Interferons;Knowledge;Link;Measures;Mediating;Membrane;Mentorship;mouse model;multidisciplinary;Natural Immunity;new therapeutic target;Nucleic Acids;Organ;Organelles;Pathogenesis;Pathway interactions;patient biomarkers;patient subsets;Patients;Persons;Physicians;Play;Process;protein expression;Proteins;Research;Research Personnel;response;Retroelements;Retrotransposition;Reverse Transcription;Rheumatism;RNA;Role;Salivary;Salivary duct structure;Salivary Glands;Scientist;sensor;Signal Transduction;Site;Sjogren's Syndrome;skill acquisition;Source;symposium;Syndrome;System;Testing;Therapeutic;therapeutic target;Tissues;Training;Visualization;Work

PROJECT_TITLE: The Retroelement LINE1 and the DNA Sensor IF16 in Sjogren's Syndrome

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: CARSON

ORG_DEPT: CHEMISTRY

ORG_NAME: CALIFORNIA STATE UNIV-DOMINGUEZ HILLS

ORG_STATE: CA

PHR: Project Narrative California State University, Dominguez Hills (CSUDH), a public 4-year, Hispanic- and Minority-serving institution, home to a diverse community of learners and educators, will offer a well-structured U-RISE program that will provide personalized guidance, organization, and support for its scholars by “meeting each student where they are” through individual student-centric approach. The proposed program leverages previous successes of various NIH-funded programs at CSUDH and draws upon relevant current academic interventions in the literature to enable a personalized, well-structured training plan. In alignment with the overall goal of the NIGMS U-RISE nationwide program, the proposed U-RISE program at CSUDH will empower a diverse pool of undergraduates to first complete their bachelor’s degree, then transition into—and, finally, complete—research- focused advanced degree programs in the biomedical sciences to become successful biomedical scientists.

PI_NAMEs: MCCAULEY, ERIN PATRICIA (contact)

PROJECT_TERMS: academic intervention;Attention;Bachelor's Degree;Behavioral Sciences;California;career;CCL7 gene;cohort;Communities;Degree program;Discipline;Doctor of Philosophy;empowerment;Enrollment;Extramural Activities;falls;First Generation College Students;Fostering;Funding;Future;Hispanic;Home;Individual;institutional capacity;interest;Literature;meetings;Minority-Serving Institution;Outcome;Performance;program dissemination;programs;Research;role model;Structure;Students;success;Training;undergraduate student;United States National Institutes of Health;Universities

PROJECT_TITLE: U-RISE at California State University Dominguez Hills

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: HL

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Heart Disease;Physical Activity;Prevention

ORG_CITY: TYLER

ORG_NAME: UNIVERSITY OF TEXAS HLTH CTR AT TYLER

ORG_STATE: TX

PHR: PROJECT NARRATIVE (3 sentences) The heart failure with preserved ejection fraction (HFpEF) can be predicted decades prior to its clinical manifestations through the identification of low normal exercise capacity in healthy, middle-aged adults. However, the mechanisms the account for this transition remains incompletely understood. This projec in patient-oriented research within the Dallas Heart Study to characterize these mechanisms.

PI_NAMEs: BERRY, JARETT D (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Accounting;Activities of Daily Living;Adult;Age;age related changes;American;Anaerobic Threshold;ATP Synthesis Pathway;Award;Berry;Biology;Cardiology;Cardiovascular system;career;Clinical;Clinical Investigator;cohort;Collaborations;Data;Databases;Diagnosis;dietary;effective therapy;EFRAC;Enrollment;Environment;Exercise;exercise capacity;exercise intolerance;Exercise Test;experience;Exposure to;Faculty;Fatty acid glycerol esters;Funding;Generations;Goals;healthy aging;Heart;Heart failure;heart failure with reduced ejection fraction;high risk;Hospitalization;Image;Imaging Techniques;Impairment;improved;in vivo;Individual;Infiltration;Infrastructure;inorganic phosphate;Institution;Intake;Kinetics;Knowledge;Laboratories;Lead;Leadership;Magnetic Resonance Imaging;Measurement;Measures;Medical center;Medicine;member;Mentors;Midcareer Investigator Award in Patient-Oriented Research;middle age;Mitochondria;mitochondrial dysfunction;mortality risk;multi-ethnic;multidisciplinary;Muscle;Names;National Institute on Aging;Natural History;older adult;Oxygen;Participant;patient oriented;patient oriented research;Patients;Peripheral;Phenotype;Physical activity;Physiology;Positioning Attribute;preservation;Prevention;Process;professor;programs;Protocols documentation;Recurrence;Reporting;Research;Research Personnel;Research Priority;Research Training;Rest;Risk;Role;sarcopenia;Skeletal Muscle;skills;support network;Testing;Training;treatment strategy;United States National Institutes of Health;Work

PROJECT_TITLE: Characterization of Mechanisms of Exercise Intolerance in Patients at Risk for Heart Failure with Preserved Ejection Fraction

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Congenital Heart Disease;Heart Disease;Pediatric;Rare Diseases;Regenerative Medicine

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE Cardiovascular disease remains a leading cause of disability and death in the USA, often necessitating surgical correction via the use of vascular grafts. We and others have designed and tested myriad tissue engineered vascular grafts based on experience gained incrementally in animal models, first in mice then in larger animals, but it has taken decades to reach FDA-approval of the first such grafts. We submit that there is a pressing need to accelerate this process and that our proposed novel computational-experimental approach has great promise to accomplish this longstanding unmet need.

PI_NAMEs: BREUER, CHRISTOPHER KANE (contact);HUMPHREY, JAY D.;MARSDEN, ALISON L

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: 3-Dimensional;Absorbable Implants;Acceleration;Adolescent;Adult;Anastomosis - action;Animal Model;Animals;Articulation;Biocompatible Materials;biodegradable polymer;Biological;Biology;Biomechanics;Biomedical Engineering;Blood Vessels;Caliber;Calibration;Cardiovascular Diseases;Cardiovascular system;Caring;Cessation of life;Child;Childhood;Clinical;clinical translation;Clinical Trials;Collaborations;Computer Models;congenital heart abnormality;Congenital Heart Surgery;Coupling;Data;design;Development;Diffuse;Dilatation - action;disability;Elements;Europe;Exhibits;experience;Extracellular Matrix;fabrication;FDA approved;Foreign Bodies;Foundations;Geometry;Goals;Growth;Hemodialysis;hemodynamics;immunoregulation;Implant;improved;improved outcome;in vivo;in vivo Model;Inflammation;Inflammatory;innovation;Investigation;lamb model;Lead;Learning;Liquid substance;Mechanics;Mediating;Methods;Modeling;Modernization;multi-scale modeling;Mus;Natural History;novel;older adult;Operative Surgical Procedures;Organ;Outcome;Paper;pediatric patients;Pediatrics;Performance;Physiological;Polymers;Positioning Attribute;postnatal;postnatal period;pre-clinical;preclinical study;predictive modeling;Process;Property;response;Safety;scaffold;Science;Scientist;Seminal;sheep model;Signal Transduction;simulation;Single ventricle congenital heart disease;Site;Solid;standard of care;Stenosis;Structure;success;Surgeon;Testing;Thrombosis;Tissue Engineering;Translations;Vascular Graft;vascular tissue engineering;Work

PROJECT_TITLE: Improving Tissue Engineered Vascular Graft Performance via Computational Modeling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(02)M]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Bacterial keratitis is a significant sight-threatening infectious disease of the cornea. This project will investigate how extracellular matrix (ECM) components of the corneal basement membrane are assembled and how certain bacterial pathogens exploit ECM fibrils of the corneal basement membrane for their attachment and infection. These studies should uncover new mechanisms of how ECM interactions regulate corneal homeostasis and how pathogens take advantage of this physiological process to promote their pathogenesis. We anticipate these studies to reveal new targets for therapy against ocular surface diseases, including bacterial keratitis.

PI_NAMEs: PARK, PYONG WOO  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Adhesions;Adhesives;Automobile Driving;Bacteria;Bacterial Adhesion;Bacterial Attachment Site;Basement membrane;Binding;Binding Proteins;Biochemical;Biological Process;Blindness;Cell surface;Cells;Communicable Diseases;comparative;Cornea;Corneal Diseases;corneal epithelium;Corneal Injury;Data;design;Environment;Epithelial Cells;Epithelium;Extracellular Matrix;Extracellular Matrix Proteins;fibrillogenesis;Fibronectins;gain of function;Goals;Gram-Negative Bacteria;Heparan Sulfate Proteoglycan;Heparin Binding;heparin receptor;Heparitin Sulfate;Homeostasis;In Vitro;in vivo;Incidence;Infection;Injury;Invaded;Keratitis;Laminin;membrane assembly;microbial;Modernization;Molecular;Morbidity - disease rate;mouse model;new therapeutic target;ocular surface;ocular surface disease;Operative Surgical Procedures;Parasites;pathogen;Pathogenesis;pathogenic bacteria;pathogenic microbe;Pathway interactions;Patients;Physiological Processes;Pneumococcal Infections;Predisposition;prototype;Public Health;receptor;Receptor Signaling;Regulation;Resources;Role;Site;Streptococcus pneumoniae;Structure;syndecan;Testing;tissue injury;Tissues;Topical application;treatment duration;Virulence;Virus;Vision

PROJECT_TITLE: ECM Regulation of Ocular Surface Disease

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ORG_CITY: ALBUQUERQUE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: PROJECT NARRATIVE Over the next five years, the U-RISE at University of New Mexico program will prepare 30 students from groups underrepresented in the biomedical sciences for PhD programs and careers in research. Our program will also advise undergraduate students about the possibilities for pursuing research careers, thereby enhancing the curriculum at our University for all STEM students. As ours is a minority-majority state with ~18% of the population living under the poverty line, our U-RISE Scholars come from populations associated with significant health disparities (diabetes, cancer, infant mortality, HIV/AIDS, and alcoholism) that afflict minorities and those in poverty, we will be training individuals who are highly motivated and skilled to carry out future research aimed at alleviating and curing these health disparities.

PI_NAMEs: TAKACS-VESBACH, CRISTINA D. (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Area;Biochemistry;Biology;Biomedical Research;career;Chemicals;Chemistry;Data;Degree program;Development;Doctor of Philosophy;Educational Curriculum;Elements;Engineering;Evaluation;experience;Goals;graduate school;improved;Information Dissemination;Mathematics;matriculation;Mentors;Methods;Molecular Biology;New Mexico;Outcome Measure;Physics;programs;Psychology;recruit;Reproducibility;Research;Schools;skills;statistics;Students;success;Time;Training;Training Programs;undergraduate research;undergraduate research experience;undergraduate student;underrepresented minority student;Underrepresented Populations;Universities;Writing

PROJECT_TITLE: U-Rise at the University of New Mexico


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Lymphatic Research;Neurosciences;Sleep Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The goals of this proposal are to (1) determine if slow and rhythmical breathing consciously performed during wakefulness through an 8-week yogic breathwork intervention will be sustained in sleep; (2) measure the effects of the intervention on subjects' long-term sleep patterns, and correlate the degree of sleep improvement with the changes in breathing patterns during sleep measured in Aim 1, and; (3) determine the influence of an 8-week yogic breathwork intervention on CSF flow dynamics and glymphatic function.

PI_NAMEs: YILDIZ, SELDA  (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Abdomen;Address;Alzheimer's Disease;Blood Pressure;Brain;Breathing;Cardiac;Central Nervous System;Central Nervous System Diseases;Cerebrospinal Fluid;cerebrospinal fluid flow;Circulation;Conscious;cost;Ensure;Equipment;experience;Frequencies;gliovascular;glymphatic function;glymphatic system;Goals;Health;Health Benefit;Heart Rate;heart rate variability;Human;imaging approach;Imaging Techniques;improved;improvement on sleep;in vivo evaluation;Intercellular Fluid;Intervention;intervention effect;Investigation;Learning;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measurement;Measures;Meditation;Metabolic;Methodology;Microcirculation;Mind-Body Intervention;multimodality;Multiple Sclerosis;Nervous System Physiology;Neurologic;non-invasive imaging;novel;novel strategies;Outcome;Participant;Pattern;Periodicals;perivascular channels;Phase;Physiology;Play;Polysomnography;post intervention;Posture;Relaxation;research study;Respiration;respiratory;Risk;Rodent;Role;Sleep;sleep pattern;sleep quality;Sleep Wake Cycle;Slow-Wave Sleep;solute;Time;United States;Wakefulness;wasting;Well in self;Yoga

PROJECT_TITLE: Quantifying the Influence of Yogic Breathwork on Cerebrospinal Fluid Circulation


ORG_CITY: KENNESAW

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: KENNESAW STATE UNIVERSITY

PHR: Project Narrative. Biomedical research lacks a presence and voice from underrepresented scientists with doctoral training. This perpetuates a lack of diverse role models and talent in the biosciences. This U-RISE grant aims to tackle this problem head-on by recruiting, training, and mentoring up to 25 underrepresented students for entry into biomedical PhD programs.

PI_NAMEs: GRIFFIN, MELANIE CHRISTINE;HUDSON, MARTIN LYN (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Address;Advisory Committees;Appointment;cohort;Communication;Creativeness;Degree program;Doctor of Philosophy;Educational Status;Effectiveness;Engineering;experience;faculty mentor;falls;Goals;Healthcare;innovation;Institution;interest;Interview;journal article;matriculation;Measurable;Mentors;Methods;Outcome;peer coaching;Preparation;Program Effectiveness;programs;recruit;Reproducibility;Research;Research Institute;Research Personnel;Research Training;Rotation;Science;skills;student participation;Students;summer research;Surveys;symposium;Talents;Technology;Training;Training and Education;Training Programs;undergraduate research;undergraduate student;Underrepresented Populations;Underrepresented Students;web site

PROJECT_TITLE: U-RISE at Kennesaw State


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Exposure of old cells and tissue to young blood leads to their rejuvenation. Likewise, exposure of young cells and tissues to old blood leads to their accelerated aging. However, how a cell is able to reset its age in response to factors in the blood remains a mystery. The main focus of the studies of this proposal is to explore the mechanisms that regulate cellular age and that are required to reset the age or a cell, either to an older age or a younger age, in response to exposure to old or young blood.

PI_NAMEs: RANDO, THOMAS A. (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Address;Affect;Age;age acceleration;age effect;aged;Aging;aging process;aging reversal;ATAC-seq;biological age;Biological Assay;Blood;cell age;Cell Aging;Cell Communication;Cell Differentiation process;cell growth regulation;Cell Reprogramming;Cells;Characteristics;ChIP-seq;comparison control;Complement;Data;demethylation;DNA Methylation;Enzymes;Epigenetic Process;epigenome;Exhibits;experimental study;Exposure to;Generations;Genetic;Genetic study;Genetic Transcription;Goals;Heterochromatin;histone demethylase;histone methyltransferase;histone modification;Histones;Homeostasis;human old age (65+);In Vitro;in vitro Model;in vivo;in vivo evaluation;induced pluripotent stem cell;inhibitor;interest;Intervention;Knock-out;Laboratory Animals;life span;Liver;Lysine;Mediating;Mediator;Methylation;methylation pattern;Methyltransferase;Molecular;Molecular Mechanisms of Action;Molecular Profiling;Mus;Muscle;muscle aging;Muscle Cells;muscle progenitor cell;Nucleosomes;old mice;Parabiosis;Pathway interactions;pharmacologic;Pharmacology Study;Phenotype;Plasma;Population;Process;Protocols documentation;Publishing;Rejuvenation;repaired;Reporting;response;restoration;Role;Serum;single-cell RNA sequencing;stem cell aging;System;Testing;Tissues;tool;transcriptome

PROJECT_TITLE: Epigenetic Reprogramming of Cellular Age


ORG_CITY: STANFORD

ORG_DEPT: ORTHOPEDICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The proposed research aims to provide new insights in Osteoarthritis (OA), an unmet medical need using new proteomic technologies. Completion of these studies will lead to an increased molecular understanding of and elucidation of patient heterogeneity in OA, which should help in accelerating drug development efforts for OA.

PI_NAMEs: BHUTANI, NIDHI  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Ablation;Acceleration;Affect;Animal Model;Animals;Antibodies;articular cartilage;Atlases;Cartilage;Cartilage Diseases;cartilage regeneration;cartilage repair;cell type;Cells;Chondrocytes;Clinical Trials;cohort;Cytometry;Data;Degenerative polyarthritis;Detection;Disease;Disease Progression;drug candidate;drug development;Encapsulated;Event;Extracellular Matrix;Failure;Goals;Heterogeneity;Homeostasis;Human;I-kappa B Proteins;In Situ;Individual;Inflammation;Inflammatory;inflammatory marker;inflammatory modulation;inhibitor;insight;Joints;Knowledge;Label;Maps;Medical;Molecular;mouse model;novel;Pain management;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacotherapy;Population;pre-clinical;Proteins;Proteomics;Publishing;Rare Earth Metals;receptor;regeneration potential;regenerative;regenerative cell;Replacement Arthroplasty;Reporting;Research;Resolution;Resources;response;Sampling;Science;senescence;senescent cell;Signal Pathway;single-cell RNA sequencing;small molecule inhibitor;Stains;success;Techniques;Technology;Testing;Therapeutic;therapeutic evaluation;Tissue Engineering;Tissues;transcriptome sequencing;transcriptomics;Traumatic Arthropathy

PROJECT_TITLE: Establishing a Single-Cell Proteomic Atlas for Normal and Osteoarthritic Articular Cartilage


ORG_CITY: MILWAUKEE

ORG_NAME: MARQUETTE UNIVERSITY

ORG_STATE: WI

PHR: Project Narrative Career requirements and skills needed to become a research scientist are not always intuitive or consistently apparent. Various obstacles within a higher educational environment can often discourage students from pursuing graduate training and science careers. U-RISE at Marquette has designed curriculum and programming to support students as they gain undergraduate research expertise while cultivating a science- identity and sense of inclusion in the science community.

PI_NAMEs: CHOI, SUJEAN ;D'ANNA-HERNANDEZ, KIMBERLY LYNN;FREY, ANGELA  (contact);HEARING, MATTHEW CARL;KLOCKOW, LAURIEANN

PROJECT_TERMS: Academic advising;Address;Applications Grants;career;Caring;Clinical Investigator;college;Communication;Communities;Development;Development Plans;diversity and inclusion;Ensure;experience;First Generation College Students;Goals;graduate school;Individual;Mentors;Methodology;Mission;Oral;Participant;patient engagement;Persons;Population;pre-clinical;pre-doctoral;Productivity;programs;recruit;Research;Research Activity;research faculty;Research Personnel;Research Training;Resources;responsible research conduct;Science;Scientist;Series;skills;Structure;Student Selections;Students;summer research;undergraduate research;undergraduate student;Underrepresented Students;Universities;Validation;Woman;Work;Writing

PROJECT_TITLE: U-RISE at Marquette University


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Genetics;Hematology;Immunotherapy;Infectious Diseases;Pediatric;Pediatric Cancer;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE The purpose of the proposed study is to determine whether one type of immune cell called the T cell can adopt qualities similar to another type of immune cell called the natural killer cell. This modified T cell exhibits the ability to recognize certain cancer cells and cells infected with a common virus and could be useful as a cell product in the treatment of certain cancers and infection. Understanding how this modified T cell contributes to the immune response is important in the treatment of patients who may become sick from the virus.

PI_NAMEs: HSU, KATHARINE C (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adopted;Allogenic;beneficiary;Blood;Bone Marrow Transplantation;cancer cell;CD28 gene;CD3 Antigens;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Line;Cell Therapy;Cells;clinical database;Clonality;Collaborations;curative treatments;Cytomegalovirus;Cytomegalovirus Infections;cytotoxic;Cytotoxic T-Lymphocytes;Development;Down-Regulation;Dysmyelopoietic Syndromes;Epigenetic Process;Event;Exhibits;Exposure to;Fibroblasts;Gene Expression Profile;Genetic;Genetic Transcription;Goals;Hematopoietic Stem Cell Transplantation;Human;Immune;immune reconstitution;Immune response;Immunologic Surveillance;Immunosuppression;imprint;In Vitro;Individual;Infection;international center;Investigation;KLRD1 gene;Leprosy;leukemia;leukemia relapse;Leukocytes;Link;Lymphocyte;Lymphoid;Lymphoid Cell;Malignant Neoplasms;Measurable;Measures;member;Memory;Molecular;Morbidity - disease rate;mortality;Natural Killer Cells;Neonatal Mortality;neonate;Organ;Outcome;pathogen;Pathway interactions;Patients;Penetrance;Peptides;Phenotype;Population;post-transplant;Preleukemia;programmed cell death protein 1;programs;receptor;recruit;Relapse;response;Risk;Sampling;seropositive;Signal Transduction;Solid;Source;Specificity;Surface;T cell response;T-Cell Development;T-Lymphocyte;terminally differentiated effector memory (TEM) T cells;Therapeutic;Thymus Gland;transcription factor;transcriptome sequencing;Transplant Recipients;tumor;Viral;Viral Physiology;Virus;Virus Diseases;γδ T cells

PROJECT_TITLE: HCMV-induced innate-like CD8 T cells and allogeneic HCT outcome

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

PHR: PROJECT NARRATIVE Alzheimer's disease (AD) related changes likely occur decades before symptoms are observed underscoring the need for novel tools that can aid in the early identification. The olfactory system has multiple unique features that make it an ideal tool to understand the neurobiology of AD, including its direct access to key brain areas that support cognitive and memory function. The proposed study aims to better understand changes in the olfactory system in prodromal AD and its relation to cognitive function using advanced imaging methods, which could ultimately facilitate the development of measures for early detection and progression of AD.

PI_NAMEs: BAKKER, ARNOLD ;HUA, JUN  (contact);KAMATH, VIDYULATA

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: abeta accumulation;accurate diagnosis;Address;Affect;Aging;aging brain;Air;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer’s disease biomarker;Amyloid beta-Protein;Anosmia;Area;Arteries;arteriole;Behavior assessment;behavior measurement;behavior test;Behavioral;biomarker development;Blood Vessels;Blood Volume;Brain;Brain region;brain tissue;cerebral autoregulation;Cerebrovascular Circulation;Cerebrovascular system;Cerebrum;Clinical;Cognition;Cognitive;cognitive function;design;Development;Diagnosis;Disease;Dropout;Early Diagnosis;Early identification;Early Intervention;Energy Metabolism;entorhinal cortex;follow-up;Foundations;functional decline;Functional disorder;high risk;Hippocampus;Human;Image;Imaging Device;imaging modality;Impaired cognition;indexing;Individual;Intervention;Investigation;Literature;Magnetic Resonance Imaging;Maintenance;Measurement;Measures;medial temporal lobe;Mediating;Memory;Memory Loss;Metabolic;metabolic rate;Metabolism;Methods;mild cognitive impairment;Morphologic artifacts;Nerve Degeneration;neural circuit;neurobiological mechanism;Neurobiology;Neurons;neuropathology;neurophysiology;neurovascular;non-invasive imaging;novel;Olfactory Cortex;Olfactory dysfunction;Olfactory Pathways;olfactory stimulus;Oxygen;Participant;Pathology;Patients;Physiological;Physiology;Population;pre-clinical;Predisposition;prodromal Alzheimer's disease;Psychophysics;research clinical testing;Resolution;response;Rest;Risk Factors;Sensitivity and Specificity;sensory system;Severities;Signal Transduction;Sinus;Smell Perception;Staging;Stimulus;Structural defect;Structure;Sum;Symptoms;System;tau Proteins;tau-1;Testing;tool;Venous;Visit;Work

PROJECT_TITLE: Advanced MR Imaging of Olfactory Impairment in Prodromal Alzheimer's Disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative  Misfolded proteins are toxic to cells and contribute to many human diseases including Alzheimer's disease and other neurodegenerative disorders. This proposal seeks to understand how cells destroy these proteins and therefore may inform important aspects of human disease.

PI_NAMEs: HANNA, JOHN W (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: 26S proteasome;Active Sites;Affinity;Affinity Chromatography;Alzheimer's Disease;Architecture;Atlases;Binding;Biogenesis;Biology;cancer therapy;cell type;Cells;Complex;Coupled;Cryoelectron Microscopy;Data;Dedications;Disease;Eukaryota;Failure;Generations;Genetic Transcription;Goals;human disease;in vitro testing;in vivo evaluation;inhibitor;innovation;insight;interest;Light;Malignant Neoplasms;Mediating;member;misfolded protein;Modeling;Molecular Chaperones;multicatalytic endopeptidase complex;Multiple Myeloma;mutant;N-terminal;Nature;Neurodegenerative Disorders;novel;novel therapeutic intervention;Nucleosome Core Particle;particle;Pathway interactions;Peptide Hydrolases;Peptides;pharmacologic;Physiological;Positioning Attribute;Process;Productivity;Proteasome Binding;Proteasome Inhibition;protein degradation;protein misfolding;Proteins;Proteolysis;proteotoxicity;Regulon;Resolution;response;Role;Shapes;Stress;Structure;Testing;Therapeutic;Time;Ubiquitin;Work;Yeasts

PROJECT_TITLE: Structural and Functional Analysis of Proteasome Core Particle Biogenesis

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: New tools are necessary for tuberculosis control. The Regional Prospective Observational Research on tuberculosis (RePORT) coordinating center (TB-RICC 3.0) will discover predictors of development of TB and poor treatment outcomes and show that they are applicable across three continents. TB-RICC 3.0 will further support development of a network of sites to study promising new diagnostics, vaccines and drugs.

PI_NAMEs: ANDRADE, BRUNO DE BEZERRIL;ELLNER, JERROLD J. (contact);STERLING, TIMOTHY R

PROGRAM_OFFICER_NAME: JONES, FATIMA D

PROJECT_TERMS: Africa;Architecture;Area;Asia;biobank;Biological Markers;biomarker evaluation;Biometry;Biotechnology;Brazil;China;Clinical;Clinical Research;Clinical Trials;Cohort Studies;Collaborations;Collection;Common Data Element;Communication;Country;COVID-19;Data;data centers;Data Collection;Data Element;data harmonization;data hub;data management;data standards;design;Development;Diagnostic;Diagnostics Research;electronic data;Elements;Ensure;Epidemiology;falls;Feedback;Foundations;frontier;Generations;Geographic Locations;Goals;Grant;HIV/TB;Human;Immunology;India;Indonesia;innovation;insight;International;Intervention Studies;Korea;Laboratories;Leadership;learning materials;Logistics;Mentors;Monitor;multiple omics;nano-string;novel diagnostics;Observational Study;Performance;Pharmaceutical Preparations;Population;predictive marker;programs;prospective;Proteomics;Protocols documentation;Publishing;Quality Control;Research;Research Design;Research Methodology;Research Personnel;Research Support;response;Review Committee;sample collection;Science;Site;South Africa;South America;Specimen;Structure;Technology;tool;transcriptomics;Translational Research;Treatment outcome;Tuberculosis;tuberculosis diagnostics;Vaccines;Validation;working group

PROJECT_TITLE: TB-RICC 3.0


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: BOZEMAN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: PROJECT NARRATIVE The manipulation of a subset of glutamate-octopamine dual transmitting neurons results in increased levels of high intensity aggression. The goal of our study is to understand how dual transmission is regulated and how the release of two transmitters from the same neuron leads to changes in aggressive behaviors. A better understanding of the mechanisms by which dual transmission is controlled may lead to novel strategies to treat elevated aggression that are associated with psychiatric disorders or neurodegenerative diseases.

PI_NAMEs: CERTEL, SARAH J;KAUN, KARLA R.;STOWERS, STEVE  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Acetylcholine;Address;Adrenergic Receptor;Age;age related;age related changes;Aggressive behavior;Aging;analog;Antibodies;Behavior;Behavioral;behavioral response;Biological Models;Biosensor;Communication;Cues;Data;Disease;Drosophila genus;Economic Burden;economic impact;Epitopes;Equilibrium;Exhibits;Female;flexibility;fly;Functional Imaging;Funding;gamma-Aminobutyric Acid;Genetic;genome editing;Glutamate Transporter;Glutamates;Goals;Human;Image;Individual;Injury;insight;Invertebrates;knock-down;male;Mental disorders;Metabotropic Glutamate Receptors;Molecular;monoamine;Nervous System;Neurodegenerative Disorders;Neuromodulator;Neurons;Neuropeptides;Neurosciences;neurotransmission;neurotransmitter release;Neurotransmitters;noradrenergic;Norepinephrine;novel strategies;Octopamine;Phenotype;Physiological;postsynaptic;postsynaptic neurons;presynaptic;presynaptic neurons;Property;receptor;receptor function;Regulation;Reproductive Behavior;Resources;response;Role;segregation;sex;Sex Differences;sexual dimorphism;Signal Transduction;small molecule;Social Behavior;Societies;socioeconomics;Specific qualifier value;System;Testing;Therapeutic;tool;transmission process;Violence;Visualization;Work

PROJECT_TITLE: Functional role of dual neurotransmission in aggression

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE This mentored research training program will prepare 25 Mongolian Fellows for careers in environmental and occupational research with a goal of influencing Mongolian health policies. The proposed Center will have strengths in studying the interactions of air pollution and acute viral infections which are major problems in Mongolia. The training will advance multidisciplinary, environmental, and occupational health research collaborations between US and Mongolian academic institutions.

PI_NAMEs: DAMBADARJAA, DAVAALKHAM -;GRAY, GREGORY CHARLES (contact)

PROGRAM_OFFICER_NAME: JESSUP, CHRISTINE

PROJECT_TERMS: Advisory Committees;Air Pollution;animal research subject;Biological Assay;career;Collaborations;Complex;Data Analyses;Doctor of Philosophy;Economics;Employment;English Language;environmental change;Environmental Health;experience;Faculty;faculty mentor;Fellowship;Financial Support;Fostering;Goals;Health;Health Professional;Human;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;International;Journals;Laboratories;Medial;member;Mongolia;National Health Policy;Occupational;Occupational Diseases;Occupational Health;Oral;Policies;Positioning Attribute;Process;programs;Publishing;Qualifying;Reproducibility;Research;Research Ethics;Research Personnel;Research Project Grants;Research Training;responsible research conduct;Science;Specimen;Training;Training Programs;Training Support;Travel;Twin Multiple Birth;Universities;Viral Respiratory Tract Infection;Work;Writing

PROJECT_TITLE: 2/2 - Mongolian Center for Environmental & Occupational Health - U.S.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Q(70)R]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative Deep brain stimulation (DBS) has been FDA approved for managing several brain disorders, including Parkinson’s disease (PD), and has been increasingly used to treat patient over the past couple decades. However, the therapeutic mechanisms of DBS remain largely unknown. This study aims to systematically study the neural circuits involved in PD, and the therapeutic mechanisms of DBS using novel single cell voltage imaging techniques.

PI_NAMEs: HAN, XUE  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Address;Affect;alpha synuclein;Anatomy;Basal Ganglia;behavioral study;Biological Markers;Biophysics;Brain;Brain Diseases;Cells;Chronic;Clinical Research;Corpus striatum structure;Deep Brain Stimulation;design;disease model;Dopamine;Dopamine Receptor;dopaminergic neuron;Electric Stimulation;Electrophysiology (science);Epilepsy;Essential Tremor;Event;FDA approved;Frequencies;Functional disorder;Future;Goals;Image;imaging study;Imaging Techniques;Implanted Electrodes;Individual;insight;Link;Measures;Membrane;Mental disorders;millisecond;Modeling;Motor;motor disorder;mouse model;Movement;Mus;Nervous System Disorder;neural circuit;Neurons;novel;Obsessive-Compulsive Disorder;Optics;Output;Oxidopamine;Parkinson Disease;Pathologic;Pathology;Pathway interactions;Patients;Pattern;pre-formed fibril;Primates;Resolution;segregation;Structure;Structure of subthalamic nucleus;Synapses;Therapeutic;Therapeutic Effect;Time;Transgenic Mice;voltage

PROJECT_TITLE: Voltage Imaging Analysis of Striatal Network Dynamics Related to Movement, Parkinson's Disease and Deep Brain Stimulation


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative Envelope (Env) glycoprotein of HIV-1, a key player in the biology of the virus, has a complex glycan shield with multiple functions. In this proposal, we will test the concept that the glycan shield is comprised of glycan-units with distinct functions and limited interchangeable positions. We will use a combination of research tools to provide novel insights into the how these clusters of glycans work together to maintain a functional Env glycoprotein and, thus, identify vulnerable regions of the glycan shield that can be targeted for intervention.

PI_NAMEs: NOVAK, JAN ;RENFROW, MATTHEW B (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Affect;Apical;Area;Binding Sites;Bioinformatics;Biological;Biology;Complex;Data;Databases;design;dimer;Engineering;Epitopes;Exhibits;Experimental Models;experimental study;Future;Glycoproteins;glycosylation;Goals;Heterogeneity;HIV;HIV Envelope Protein gp120;HIV-1;Human Biology;Immune;Immune response;Immune system;Infection;Informatics;insight;Intervention;Mannose;Methodology;Modeling;Molecular;Molecular Biology;molecular dynamics;molecular mass;Mutate;N Domain;N-Glycosylation Site;neutralizing antibody;novel;pathogen;Penetration;Persons;Polysaccharides;Positioning Attribute;prevent;Process;Publications;Publishing;receptor;Recombinants;Research;Role;Sequence Analysis;Series;Site;Structure-Activity Relationship;Surface;Surface Antigens;Tertiary Protein Structure;Testing;Therapeutic;Time;tool;Variant;viral transmission;Virus;Virus Replication;Work

PROJECT_TITLE: Defining the impact of glycan-microdomains of the HIV-1 Env glycan shield

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Atrial fibrillation (AF) is afflicting over 33 million people worldwide to date and its prevalence is expected to increase dramatically in the future. This proposal aims at studying new modalities for characterizing the AF in computer and sheep models to describe new mechanisms of patterns of the electrical activity during its onset and cessation. Accomplishment of the proposal aims will enhance our understanding of AF and possibly lead to improved risk stratification and guide therapeutic interventions.

PI_NAMEs: BERENFELD, OMER  (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TITLE: Electrical Activity Patterns in Onset and Cessation of Atrial Fibrillation

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Developing the next generation of career biomedical scientists is essential for the successful pursuit of new treatments for diabetes, digestive, and kidney diseases; support through this new predoctoral training grant at Mayo Clinic will assist in attaining this goal.

PI_NAMEs: BILLADEAU, DANIEL D;MC NIVEN, MARK A. (contact)

PROGRAM_OFFICER_NAME: KAMARA, FANTA

PROJECT_TERMS: multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;pre-doctoral;Training;Translational Research

PROJECT_TITLE: NIDDK Multidisciplinary Predoctoral Training in Discovery and Translational Research


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Genetics;Human Genome;Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The smallest airways in the human lung are called the respiratory airways and are a site of injury in many chronic lung diseases including Chronic Obstructive Lung Disease (COPD). We have identified a new lung stem cell in this region that is altered in COPD, potentially affecting the lung's ability to heal and repair. Understanding the mechanisms that regulate this cell type will help identify new avenues for treatment in COPD.

PI_NAMEs: BASIL, MARIA CIOCCA (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Advisory Committees;Affect;airway epithelium;Alveolar;alveolar epithelium;Area;Award;Bioinformatics;career;Cell Fate Control;Cell Maintenance;Cell Physiology;cell type;Cells;Cellular biology;Chronic lung disease;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;Clinical;clinically relevant;Communities;Critical Care;Data;Data Analyses;Development Plans;Disease;Distal;Doctor of Philosophy;Epigenetic Process;epigenomics;Epithelial Cells;epithelial stem cell;Epithelium;Fellowship;gene regulatory network;Genes;Genetic Transcription;genomic data;Genomics;Goals;healing;Health;high resolution imaging;Human;human embryonic stem cell;human stem cells;Injury;insight;Institution;International;Knock-out;Knowledge;Lead;Lung;lung injury;lung regeneration;lung repair;Maintenance;Mentors;Molecular;Molecular Biology;Morbidity - disease rate;mortality;mouse model;Mus;Natural regeneration;next generation sequencing;notch protein;novel;Oranges;Organ;Pathogenesis;Pathway interactions;Pennsylvania;Population;progenitor;programs;Regulation;repaired;Research;Research Personnel;Resources;respiratory;Respiratory Disease;Respiratory physiology;response to injury;Role;Scientist;Secretory Cell;self-renewal;Signal Transduction;single cell ATAC-seq;Site;skills;small airways disease;SOX4 gene;stem cell function;stem cell model;stem cells;Structure;Structure of parenchyma of lung;Structure of respiratory bronchiole;Techniques;Testing;Therapeutic;Training;transcription factor;Transcriptional Regulation;Universities;University Hospitals;Work

PROJECT_TITLE: Molecular regulation of cell fate and progenitor function in the distal human respiratory airways

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: KANSAS CITY

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE We predict that olfactory dysfunction testing using AROMA – a novel, essential oil-based, objective test of olfaction – and machine learning algorithms using this data will accurately classify Alzheimer’s disease stage (including asymptomatic individuals); be strongly associated with and predictive of conventional biomarkers of disease; and predict longitudinal functional trajectory. The ability to effectively screen for ADRD using a non- invasive and accessible test is critical to public health and our ability to identify people early when disease course is most likely to still be modifiable. Accurate prediction of future functional decline will also meaningfully inform comprehensive care planning and improved counseling of patients and their families.

PI_NAMEs: VILLWOCK, JENNIFER  (contact)

PROJECT_TERMS: Age;aging population;Algorithms;Alzheimer disease screening;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Biological Markers;Blood specimen;Brain;burden of illness;Caregivers;Caring;Categories;Chemicals;Classification;Clinical;Clinical Markers;clinical trial enrollment;clinically relevant;clinically significant;Clove;Cognition;Cognitive;cognitive testing;cohort;Communities;Complex;Comprehensive Health Care;cost effective;Counseling;Data;Dementia;dementia risk;design;Detection;Diagnostic tests;Disease;Disease Marker;Dreams;Early Intervention;early phase clinical trial;early screening;Ensure;Evaluation;exercise capacity;Family;frailty;functional decline;Functional disorder;functional status;Future;Goals;Health;Hippocampus;Home;human old age (65+);improved;Individual;Infrastructure;interest;Intervention;Lavandula;Life;Machine Learning;machine learning algorithm;Measurement;Measures;medical specialties;men;Methods;mild cognitive impairment;Mind;Monitor;Nerve Degeneration;Neuroanatomy;Neurocognition;Neurocognitive;Neurologic;novel;Odors;Olfactory dysfunction;Outcome;Pathology;Patients;Pattern;Pennsylvania;Performance;Persons;Phenotype;piriform cortex;Plasma;point of care;Population;Positron-Emission Tomography;pre-clinical;predictive marker;predictive modeling;Predictive Value;primary care setting;Process;Public Health;Questionnaires;Registries;Research;response;Risk;screening;Services;Smell Perception;Specificity;statistics;tau Proteins;tau-1;Techniques;Testing;Time;Triage;underserved community;United States;Universities;Validation;Volatile Oils;Woman;Work

PROJECT_TITLE: Olfactory Phenotypes as Non-Invasive Biomarkers for Alzheimer's Disease: A Machine Learning Approach


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative This project combines the expertise of Johns Hopkins University and the University of Illinois at Urbana- Champaign to develop a safe and broadly protective combination vaccine against enterotoxigenic Escherichia coli (ETEC) and Shigella, two leading causes of children’s diarrhea and travelers’ diarrhea. Currently, there is no licensed vaccine for either ETEC or Shigella, but the novel epitope- and structure- based MEFA (multiepitope fusion antigen) vaccinology platform together with appropriate animal challenge models make feasible the development and evaluation of a safe and broadly protective multivalent combination vaccine for ETEC and Shigella. An effective ETEC-Shigella vaccine will have a major beneficial impact on children’s health, and this MEFA technology may be applied generally for safe and precision multivalent vaccine development.

PI_NAMEs: SACK, DAVID A (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Adhesions;Adult;age group;Animal Model;Animals;Antibiotic Therapy;Antibiotics;Antibodies;Antibody Response;antibody test;Antibody titer measurement;Antibody-mediated protection;Antigens;Antimicrobial Resistance;Bacterial Adhesins;Biological Assay;Blocking Antibodies;Cessation of life;Child;Child Health;Childhood;Chimeric Proteins;Clinical;colonization factor antigens;Combined Vaccines;cytotoxicity;Developing Countries;Development;Development Plans;Diarrhea;diarrheal disease;Disease;enteric infection;enterotoxigenic Escherichia coli;Enterotoxins;Enzyme-Linked Immunosorbent Assay;Epitopes;Escherichia coli;Escherichia coli Adhesins;Escherichia coli EHEC;Escherichia coli Proteins;Escherichia coli Vaccines;Evaluation;experience;Family suidae;global health;Goals;Heterogeneity;Human;Illinois;Immune response;Immunity;Immunization;Immunize;immunogenic;immunogenicity;Immunologics;improved;Infant;Infection;infection rate;Injectable;innovation;International;Intestines;Invaded;invention;Laboratories;Licensing;low and middle-income countries;Lung;Measures;Modeling;Mus;novel;oral vaccine;Oryctolagus cuniculus;Outcome;Population;porcine model;pre-clinical;preclinical efficacy;Preparation;prevent;product development;Production;Proteins;Pulmonary Challenge;Records;Research Personnel;response;Sanitation;Schedule;Serotyping;Serum;Shiga Toxin;Shigella;Shigella boydii;Shigella Infections;Shigella Vaccines;Structure;Technology;Testing;testing services;Time;Toxicology;Toxin;Toxoids;Traveler's diarrhea;United States National Institutes of Health;Universities;vaccination schedule;Vaccine Antigen;vaccine candidate;vaccine development;vaccine evaluation;Vaccine Research;Vaccines;vaccinology;Virulence;Water

PROJECT_TITLE: A cross protective multivalent vaccine for Shigella and ETEC

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Genetics;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE While prior research has highlighted biological, cognitive, and caregiving factors that increase risk for child attention problems, the impact of trajectories of these risk factors in relation to trajectories of inattention have yet to be studied. This study examines initial levels and change in DNA methylation, executive function, and caregiver psychological distress as predictors of inattention trajectories in a sample of 568 very preterm children. The proposed training and research activities will improve understanding of the strongest individual or combined risk factors for attention problems in this high-risk population, help us identify sensitive periods at which biological, cognitive, and caregiving factors are most predictive of functional outcomes, and provide critical information regarding the optimal focus and timing for future interventions.

PI_NAMEs: CAMEROTA, MARIE  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: adverse outcome;Age;Attention;Attention deficit hyperactivity disorder;Behavioral;Biological;Biological Markers;Birth;career;Caregivers;caregiving;Child;Childhood;clinically relevant;clinically significant;Cognitive;Data;Data Analyses;Development;diagnostic criteria;DNA Methylation;DNA Sequence;early childhood;Early identification;Early Intervention;endophenotype;Environment;Environmental Risk Factor;Epigenetic Process;executive function;experience;extreme prematurity;Functional impairment;functional outcomes;Future;Gene Expression;Genes;Grant;Heterogeneity;high dimensionality;high risk;high risk population;Hospitals;Human;improved;inattention;Individual;Individual Differences;Infant;Intervention;Joints;K-Series Research Career Programs;Life;life span;Location;Longitudinal Studies;Measures;Mediating;medical schools;Mental disorders;Mentors;Mentorship;Mission;National Institute of Mental Health;Neonatal;neural;neurobehavior;Neurocognitive Deficit;novel;Outcome;parent grant;Pattern;performance based measurement;Phenotype;Population;Pregnancy;preterm newborn;programs;psychological distress;Psychopathology;rate of change;Research;Research Activity;resilience;Resources;response;Risk;Risk Factors;Role;Sampling;scaffold;Schools;skills;Statistical Models;Strategic Planning;Structure;Symptoms;synergism;Techniques;Testing;Training;Training Activity;tv watching;Universities;Woman;Work

PROJECT_TITLE: Longitudinal Antecedents of Attention Problems in Very Preterm Children: Role of Epigenetics, Executive Function, and Caregiver Psychological Distress

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PUBLIC HEALTH RELEVANCE Candida auris has rapidly emerged as a multi-drug resistant pathogen and public health threat associated with significant morbidity and mortality. In 2019, a CDC report listed C. auris among the most urgent antimicrobial resistance threats in the United States. It is of vital importance to understand how resistance develops in C. auris, so that this knowledge can be translated into therapies that prolongs the lives of affected individuals.

PI_NAMEs: CUOMO, CHRISTINA A;ROGERS, P. DAVID (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Affect;Amphotericin B;anti-fungal agents;Antimicrobial Resistance;Azole resistance;Azoles;Candida;Candida auris;candidate identification;Candidiasis;Cells;Centers for Disease Control and Prevention (U.S.);ChIP-seq;Clinical;Collection;combat;cost;CRISPR/Cas technology;Data;Death Rate;Development;Diagnostic;Disease Outbreaks;Drug Design;drug development;Drug resistance;echinocandin resistance;emerging pathogen;Epidemiology;Exhibits;fitness;Fluconazole resistance;Fungal Drug Resistance;Gene Expression Profiling;Genes;Genetic;Genetic Determinism;genome wide association study;Genomics;glucan synthase;Goals;Individual;Infection;Knowledge;Link;Maps;Mediating;Methyltransferase;Molecular;Morbidity - disease rate;mortality;Multi-Drug Resistance;multi-drug resistant pathogen;Multiple Fungal Drug Resistance;Mutation;novel;Organism;Outcome;pathogenic fungus;Prediction of Response to Therapy;Public Health;public health relevance;Publishing;Reporting;Resistance;Resistance development;resistance gene;resistance mechanism;resistance mutation;Sterols;Testing;Therapeutic;Time;time use;tool development;transcription factor;transcriptome sequencing;Translating;United States;Work

PROJECT_TITLE: Mapping the genomic and molecular mechanisms of antifungal resistance in the emerging fungal pathogen Candida auris

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(83)]


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE Tissue aging and disease is caused, in part, by accumulation of pro-inflammatory senescent cells in aged tissues. We will define novel molecular mechanisms responsible for this inflammatory phenotype and test novel interventions for their ability to suppress this proinflammatory pathway. This can provide new targets and strategies for interventions in humans to promote healthy aging and longevity.

PI_NAMEs: ADAMS, PETER D. (contact)

PROJECT_TERMS: age effect;aged;Aging;Autophagocytosis;Binding Proteins;Bulla;Cell Aging;cell injury;Cell Nucleus;Cells;Cellular Stress;Characteristics;Chromatin;Chronic;combat;Cytoplasm;Data;Development;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA Repair Pathway;Double Strand Break Repair;Event;Excision;Gamma-H2AX;genome integrity;Genomic DNA;Glycolysis;healthy aging;HIF1A gene;histone modification;Histones;Human;Hypoxia Inducible Factor;immune clearance;Impairment;in vivo;Inflammation;Inflammatory;inhibitor;Intervention;Link;Longevity;Malignant Neoplasms;MAPK8 gene;Mediating;Metabolism;Mitochondria;Modeling;Molecular;N-terminal;NF-kappa B;novel;Nuclear;nuclease;p53-binding protein 1;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;Premalignant Cell;preservation;prevent;pro-aging;Process;Proliferating;Reactive Oxygen Species;Recycling;response;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;senomorphic;sensor;Sequence Deletion;Signal Transduction;Source;Stains;Testing;Tissues;Toxic effect;trafficking;Transcription Coactivator;transcription factor;tumor;Tumor Suppression;Up-Regulation

PROJECT_TITLE: Cytoplasmic chromatin fragments in cell senescence - novel mechanisms and interventions

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Histone modifications serve as key epigenetic marks with dynamic functions in many cellular processes. This proposal aims to characterize the role of histone H3 lysine 36 methylation, a mark of active transcription, in the specification and maintenance of colon cell lineages. Defining the regulatory networks that govern cell fate decisions and reinforce cell identity in the colon is necessary to understand tissue health and disorder.

PI_NAMEs: MEYER, ANNE R. (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: absorption;Address;Biological Models;Blood;Cancer Patient;Candidate Disease Gene;candidate identification;Cell Differentiation process;Cell Fate Control;Cell Lineage;Cell Maintenance;Cell Physiology;cell type;Cells;Chromatin;Chromatin Structure;Colitis;Colon;comparative;Complementary RNA;Data;Dedications;Disease;DNA;DNA Sequence;DNA-Directed RNA Polymerase;Dominant-Negative Mutation;Epigenetic Process;epigenetic regulation;epigenomic profiling;Epithelial Cells;Epithelium;experimental study;Fluorescence-Activated Cell Sorting;Gene Expression;Genes;Genetic Transcription;genome-wide;Goblet Cells;Health;Histone H3;histone methylation;histone modification;Histones;Homeostasis;Human;inhibitor;innovation;knock-down;Knockout Mice;Lysine;Maintenance;Malignant Neoplasms;Messenger RNA;Methionine;Methylation;Methyltransferase;Modeling;Mucous body substance;Mus;mutant;mutant mouse model;Mutation;N-terminal;novel;Organoids;Physiology;Play;Polymerase;Population;Post-Translational Protein Processing;Process;Production;programs;Proteins;Protocols documentation;recruit;RNA Polymerase II;Role;scaffold;self-renewal;single-cell RNA sequencing;Site;small hairpin RNA;Sorting;Specific qualifier value;stem cells;System;Tail;Testing;Testis;Tissues;tool;transcriptome sequencing;Water;Work

PROJECT_TITLE: Epigenetic regulation of lineage specification in colon epithelial cells


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative This project seeks to identify objective, biological markers of psychosis risk by utilizing ‘big data’ to assess how deviations from pediatric neurodevelopmental growth charts predict which individuals are at greatest risk for developing psychosis. We will then assess how high-performance, low-field MRI can be used to measure these indices, a key step for future use of these measures in community settings. Results from this study will lead to earlier detection and intervention of those at greatest risk and make these assessments easily accessible to all, ultimately improving outcomes and potentially preventing the onset of psychosis.

PI_NAMEs: JALBRZIKOWSKI, MARIA  (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: 20 year old;Adolescence;Adolescent;Adult;Age;age related;archived data;Behavioral;Big Data;Biological;Biological Markers;Brain;brain based;Brain region;case control;Childhood;Classification;Clinical;cognitive development;cohort;Communities;community setting;cost effective;cost effectiveness;Data;Data Set;Development;Diagnosis;Distress;Early Diagnosis;Early identification;Early Intervention;effective intervention;emerging adult;Family history of;Future;Genetic;gray matter;Growth;Height;Heterogeneity;Image;improved;improved outcome;indexing;Individual;innovation;Knowledge;Magnetic Resonance Imaging;Maps;Measurement;Measures;Mental disorders;Methodology;Methods;Modeling;MRI Scans;neural;neurodevelopment;neuroimaging;novel;obstetrical complication;pediatrician;Performance;Persons;Philadelphia;polygenic risk score;portability;prevent;Prevention approach;Primary Prevention;Proxy;Psychopathology;Psychoses;psychosis risk;Psychotic Disorders;psychotic symptoms;psychotic-like experiences;Research;Risk;Risk Factors;Risk Marker;risk prediction;Sampling;Schizophrenia;Severities;Structure;Symptoms;synergism;Testing;Time;Translating;Trauma;Weight;Youth

PROJECT_TITLE: Predicting psychosis risk in youth using a novel structural neuroimaging score that measures deviation from normative development. Can we bring it to communities using portable, low-field MRI?


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Social Determinants of Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Among SARS-CoV-2-infected individuals, we have seen the emergence of a subset of patients with persistent symptoms, including fatigue, shortness of breath, brain fog, sleep disorders, fevers, gastrointestinal symptoms, anxiety, and depression lasting in duration from several weeks to many months. These symptoms, collectively known as PASC, or “long-COVID”, occur in a sizable proportion of SARS-CoV-2 infected individuals and range from mild to incapacitating, with profound effects on quality of life. We propose applying new statistical approaches to characterize the risk factors for PASC and to determine how best to treat patients with PASC.

PI_NAMEs: FOULKES, ANDREA S (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: 2019-nCoV;Address;Adrenal Cortex Hormones;analytical tool;Anxiety;Biological;Biological Markers;Body mass index;brain fog;C-reactive protein;Cessation of life;Characteristics;Clinical;clinical investigation;Clinical Research;cohort;Communities;Computer software;coronavirus disease;COVID-19;COVID-19 pandemic;Data;data harmonization;data resource;Data Set;data streams;demographics;Diabetes Mellitus;Disease;disorder subtype;Electronic Health Record;Ethnic Origin;Event;expectation;Fatigue;Fever;food insecurity;Functional disorder;gastrointestinal symptom;Housing;Individual;inflammatory marker;innovation;Inpatients;interest;Intervention;Investments;Knowledge;Lead;lifestyle factors;Long COVID;marginalized population;Measures;Mediation;Mediator;Mental Depression;Methods;Microvascular Dysfunction;mortality;novel;open source;Organ;Outcome;Outpatients;Pathway interactions;patient subsets;Patients;persistent symptom;Pharmacologic Substance;Physicians;Post-Acute Sequelae of SARS-CoV-2 Infection;Quality of life;Race;Recovery;repository;Research;Resolution;Risk;Risk Factors;SARS-CoV-2 infection;Scientist;Severities;sex;Shortness of Breath;Sleep Disorders;Smoking;social determinants;social health determinants;Source;Statistical Methods;Structural Models;Subgroup;supplemental oxygen;Symptoms;Time;tool;Translations;United States National Institutes of Health;Viral;virus genetics

PROJECT_TITLE: Statistical Methods in COVID-19/PASC Clinical Research

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Neurosciences;Regenerative Medicine

ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed research investigates novel mechanisms in axon regeneration, a critical process that can restore function after nerve injury. Failure of neurons to regenerate and rebuild circuits after injury results in permanent functional loss and is a significant burden on public health. The research proposed here is expected to result in fundamental knowledge that suggests ways to promote functional recovery after nerve injury.

PI_NAMEs: HAMMARLUND, MARC  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Address;Affect;Aging;Axon;axon injury;axon regeneration;Behavioral Assay;Biological;Caenorhabditis elegans;cell assembly;cell growth regulation;Cell Physiology;Cells;Cellular biology;Complex;Data;Defect;Dendrites;Development;Developmental Process;Disease;Electron Microscopy;experimental study;Failure;functional loss;Functional Regeneration;functional restoration;Genetic;genetic approach;Genomics;Goals;Growth;healing;Human;improved;in vivo;in vivo regeneration;Injury;insight;Knowledge;Link;Location;Maintenance;MAPK8 gene;Mediating;Mitochondria;model organism;Molecular;Natural regeneration;nerve injury;Nervous System;nervous system development;Nervous System Trauma;Neuronal Injury;Neurons;Neurosciences;notch protein;novel;novel strategies;Outcome;Output;Pathway interactions;postsynaptic;presynaptic;prevent;Process;Property;Public Health;real-time images;reconstruction;Recording of previous events;Recovery of Function;Regulation;Research;restoration;Signal Transduction;Site;Structure;Synapses;synaptic function;synaptogenesis;System;targeted treatment;Time;trafficking;transmission process;Work

PROJECT_TITLE: New mechanisms in axon regeneration

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Brain Disorders;Neurodegenerative;Neurosciences;Parkinson's Disease;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Exposure to environmental toxicants including pesticides causes dopamine (DA) neuron loss in the substantia nigra and raises risk for developing Parkinson’s disease (PD), with important sex differences where females lose fewer DA neurons than males. We have identified the vesicular glutamate transporter VGLUT2 in mammals and its Drosophila ortholog dVGLUT as modulators of sex differences in DA neuron resilience. Our proposed studies of dVGLUT/VGLUT2’s roles in sex differences in DA neuron resilience in the context of environmental toxicant exposures may provide new insights into PD and ultimately may lead to new, effective treatments to either slow or stop PD neurodegeneration in men and women.

PI_NAMEs: FREYBERG, ZACHARY  (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Age;Aging;alpha synuclein;Autopsy;Biogenesis;Biological Markers;Brain;brain tissue;cohort;comparative;Cytoplasm;Data;disease model;disorder control;Dopamine;dopaminergic neuron;Dose;Drosophila genus;effective therapy;Environmental Monitoring;exposed human population;Exposure to;Female;female sex hormone;fly;Genes;Genetic;Genetic Transcription;Glutamate Transporter;Glutathione;Human;Imaging Device;Injury;insight;knock-down;Knock-out;Link;male;Mammals;Mediating;men;Midbrain structure;Mitochondria;mitochondrial metabolism;Nerve Degeneration;neuron loss;Neuronal Injury;neuronal survival;neuroprotection;Neurotoxins;novel;Orthologous Gene;Ovariectomy;overexpression;Paraquat;Parkinson Disease;Pathway interactions;Patients;pesticide exposure;Pesticides;Rattus;Reactive Oxygen Species;Recycling;Regulation;resilience;response;Risk;Rodent;Rodent Model;Role;Rotenone;sex;Sex Differences;sexual dimorphism;Substantia nigra structure;Testing;Toxic Environmental Substances;toxicant;Toxicant exposure;transcriptome sequencing;Translating;Translational Regulation;Vesicle;Woman;women versus men;Women's cohort

PROJECT_TITLE: Novel roles of VGLUT in sex differences in dopamine neuron vulnerability to environmental toxicant-induced neurodegeneration

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]