ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative Our goal is to determine the effect gestational age at delivery has on lactation outcomes using state of the science biologic measures including mother's own milk (MOM) volume, secretory activation, and biomarkers (sodium, citrate, lactose, protein) in pump-dependent mothers of preterm and critically ill infants. Results of this prospective cohort study targeting the biology and physiology of insufficient MOM among NICU mothers are expected to move science towards filling the gap in understanding these mechanisms with gestational age as a nonmodifiable factor that may influence MOM volume and secretory activation in NICU mothers to: 1) identify and prioritize evidence based lactation care to increase lactation success in mothers of all gestational aged infants, and 2) gain new knowledge on biomarkers that may hold promise as objective outcome measures and point-of-care testing to identify and proactively manage mothers at risk for delayed and/or impaired secretory activation and compromised lactation, thus improving infant health outcomes and health equity.

PI_NAMEs: BENDIXEN, MARION MARLER (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: Achievement;Admission activity;Area;autocrine;Back;Behavior;Biological;Biological Markers;Biological Process;Biological Sciences;Biology;Biometry;Birth;Black race;Brain;breast pump;career;Caring;cell preparation;Citrates;Clinical;clinical application;Clinical Research;clinical translation;Complex;cost;Critical Illness;Data;data acquisition;Data Analyses;Dependence;Diabetes Mellitus;diaries;Dose;Early identification;economic disparity;Enrollment;Ensure;Environment;Epithelial Cells;evidence base;Experimental Designs;Exposure to;extreme prematurity;Faculty;Florida;Frequencies;Future;Gases;Gestational Age;Goals;Grant;Growth and Development function;Health;health equity;Hospitalization;Human;Human Milk;Hypertension;immunoregulation;Impairment;improved;Infant;Infant Development;Infant Health;Inflammation;Interruption;Knowledge;Lactation;Lactose;Late pregnancy;Leadership;Legal patent;Lung;Lung Diseases;Mammary gland;maternal serum;Measures;Mediating;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Metabolic Pathway;Milk;milk removal;milk volume;Morbidity - disease rate;Mothers;National Institute of Nursing Research;Neonatal Intensive Care Units;Normal Range;Nutrient;nutrition;Nutritional Support;Obesity;Organ;Osmosis;Outcome;Outcome Measure;Oxidative Stress;Pathway interactions;patient oriented research;Pediatric Hospitals;personalized intervention;personalized medicine;Physiology;point of care;point of care testing;Population;Postpartum Period;Pregnancy;Pregnant Women;premature;Premature Birth;Process;Production;Productivity;Prospective, cohort study;Proteins;Published Comment;Pump;Race;racial disparity;rate of change;Research;research faculty;Research Personnel;Research Priority;Resources;response;Risk;Risk Reduction;Sampling;Science;Seminal;Senior Scientist;Sepsis;skills;Societies;Sodium;standard measure;Stress;stressor;success;Techniques;Training;Translating;Translational Research;United States National Institutes of Health;Universities;Up-Regulation;Vulnerable Populations;Writing

PROJECT_TITLE: The effect of gestational age at delivery on lactation outcomes in pump-dependent mothers of critically ill infants

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(85)]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative This RFA seeks to develop novel cell and gene therapy therapies to treat individuals suffering from T1D. Our underlying hypothesis is that by engineering and re-directing suppressive and/or regulatory T cells to the transplanted islet we block acute allograft rejection resulting in long term tolerance and islet function.

PI_NAMEs: DURAN-STRUUCK, RAIMON ;NAJI, ALI ;RILEY, JAMES L. (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Acids;Acute;allograft rejection;Alpha Cell;Autoimmune Diseases;Beta Cell;Blood Glucose;Cancer Patient;CD19 gene;Cell Physiology;Cell Therapy;Cells;Cellular immunotherapy;Cessation of life;Childhood Leukemia;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic Disease;Clinical Trials;cost;Coupled;Data;diabetes mellitus therapy;Diagnosis;Dipeptidyl Peptidases;Disease;Disease remission;Effector Cell;empowerment;engineered T cells;Engineering;experience;experimental study;fibroblast-activating factor;first-in-human;Foundations;Funding;Future;gamma-Aminobutyric Acid;gene therapy;Genes;Goals;Health;HLA Antigens;Human;humanized mouse;Immune;Immune system;Immunosuppression;Immunosuppressive Agents;improved;In complete remission;in vivo;Individual;Injections;innovation;Institution;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Interleukin-2;Investments;islet;Islet Cell;Islets of Langerhans Transplantation;Lead;Leadership;Malignant Neoplasms;Mediating;Modeling;Monitor;mouse model;nonhuman primate;novel therapeutics;Phase I Clinical Trials;Physicians;Pre-Clinical Model;prevent;Process;Production;programmed cell death ligand 1;Regulatory T-Lymphocyte;Research Personnel;Safety;screening;success;Suppressor-Effector T-Lymphocytes;synergism;System;T cell therapy;T-Lymphocyte;Testing;Transplant Recipients;Transplant Surgeon;Work

PROJECT_TITLE: Engineering T cells to Promote Islet Transplant


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: IRVINE

ORG_NAME: VITALEX BIOSCIENCES, LLC

ORG_STATE: CA

PHR: Current treatment options for mucormycosis are inadequate, and fail in 50% or more of infected patients. The fungus uses CotH proteins to cause disease, and antibodies targeting CotH are curative in animal models especially when combined with antifungal drugs currently used to treat the disease. We propose to further the manufacturing of a suitable form of an antibody targeting CotH to enable future clinical testing.

PI_NAMEs: IBRAHIM, ASHRAF S.;LAZAR, GARY  (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Adrenal Cortex Hormones;Affinity;alveolar epithelium;analytical method;Animal Model;anti-fungal agents;Antibodies;Antifungal Therapy;Antigens;Binding;Biological Sciences;Bioreactors;Bone Marrow Transplantation;Brain;candidate selection;Capital Financing;Capsid Proteins;cell bank;Cell Line;Cell surface;Cells;cGMP production;Chinese Hamster;Chinese Hamster Ovary Cell;Clinical;Clinical Trials;Collaborations;Combined Modality Therapy;COVID-19;COVID-19 patient;cross reactivity;Development;Diabetes Mellitus;diabetic;Diabetic Ketoacidosis;Disease;Disease Progression;efficacy evaluation;Endothelial Cells;Epidemic;Epithelial Cells;Extracellular Matrix;Formulation;Funding;fungus;Future;Germination;glucose-regulated proteins;Goals;GRP78 gene;Hematogenous;Hematopoietic;high risk;Human;human tissue;humanized monoclonal antibodies;Hyphae;IgG1;Immune response;Immunocompetent;Immunocompromised Host;immunosuppressed;Immunotherapy;improved;Incidence;India;Industrialization;Infection;innovation;Integrin alpha3beta1;Intention;interest;Invaded;Investigation;Iron;Laboratories;Life;manufacture;manufacturing run;method development;Methods;Modeling;Molecular;Monoclonal Antibodies;mortality;mouse model;Mucorales;Mucormycosis;murine monoclonal antibody;Mus;Mycoses;Nasal Epithelium;Neutropenia;novel;novel therapeutics;Operative Surgical Procedures;Organ Transplantation;Orphan Drugs;Outcome;Ovary;Parents;Pathogenesis;Patients;Pericytes;Phase;phase 2 study;Positioning Attribute;pre-clinical;preclinical toxicity;Prevalence;prevent;Prevention;Prevention strategy;Probability;Process;Production;programs;Prophylactic treatment;Proteins;Rattus;Recovery;Reference Standards;Reporting;Reproduction spores;Research;research clinical testing;Risk;Risk Factors;Safety;scale up;Serum;Small Business Innovation Research Grant;Solid;standard of care;Surface Antigens;synergism;Target Populations;Therapeutic;therapy outcome;Tissues;Toxic effect;Toxicokinetics;Transplant Recipients;treatment strategy;Viral;wound

PROJECT_TITLE: Humanized monoclonal antibodies to treat mucormycosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-F(12)]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Substance Misuse

ORG_CITY: BROOKLYN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

ORG_STATE: NY

PHR: Project Narrative This project, "Research Training for Substance Use Mediated HIV Epidemic in Kazakhstan," will build capacity to address evidence-based interventions related to an IDU- mediated HIV epidemic in Kazakhstan through research training at Asfendiyarov Kazakh National Medical University (KNMU) in Almaty, thereby addressing the NIH HIV research priority of reducing the incidence of HIV. The selected scientific area for which HIV research training is proposed is strengthening in-country expertise in identifying processes to integrate people who inject drugs into HIV care in the era of COVID. The public health relevance of the expected increased HIV research capacity is that all training is designed to bolster research capacity focused on the intersection of substance use disorder and the HIV treatment cascade ultimately reducing both HIV incidence and HIV morbidity and mortality.

PI_NAMEs: DEHOVITZ, JACK A (contact);NUGMANOVA, ZHAMILYA

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: addiction;Address;Behavioral;Biometry;certificate program;clinical center;Collaborations;Communicable Diseases;Communities;cost effective;Country;COVID-19 pandemic;Data;delivery complications;Dermatology;design;Development;Educational Curriculum;Educational workshop;Epidemic;Epidemiology;Faculty;Goals;Health Sciences;HIV;HIV Infections;Individual;International;Intervention;Investments;Kazakhstan;Measures;Mediating;Medical;meetings;mental health center;Modality;programs;Public Health Schools;Recording of previous events;Research;Research Design;Research Proposals;Research Support;Research Training;Role;Students;substance use;Substance Use Disorder;substance use treatment;Surveys;Teacher Professional Development;Training;Training Programs;United States Public Health Service;Universities


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project Narrative Our ability to predictably harness the microbiota for beneficial health outcomes requires a fundamental understanding of the physiology of these bacteria, yet most human gut bacteria have never been studied using molecular genetic tools. In this proposal, we aim to address this major gap in our functional understanding of gene functions in human gut bacteria through systematic efforts to optimize transformation efficiency, construct barcoded transposon-insertion libraries, and map gene-phenotype relationships in vitro and in vivo.

PI_NAMEs: BUIE, CULLEN RICHARD (contact);DEUTSCHBAUER, ADAM M;HUANG, KERWYN C.

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Address;Adoption;anti-microbial peptide;Antibiotics;Archives;Area;Assessment tool;Attention;Back;Bacteria;Bacterial Physiology;Bacteriology;Bar Codes;Biological Process;Cells;Chromosome Mapping;Collection;commensal bacteria;commensal microbes;Communities;Consumption;cross immunity;Data;Data Set;Development;Diet;Disease;Distant;Ecosystem;Electroporation;Engineering;Environment;experimental study;extreme temperature;feeding;Feeds;Fiber;fitness;Gastrointestinal tract structure;gene function;Gene Modified;Gene Transfer;Generations;Genes;Genetic;Genetic Transformation;genome-wide;Genotype;Germ-Free;Gnotobiotic;Goals;Grant;Growth;gut bacteria;gut microbiome;gut microbiota;Health;Heterogeneity;high throughput screening;host-microbe interactions;Human;Human Engineering;human microbiota;Image;imaging modality;In Vitro;in vivo;Individual;innovation;innovative technologies;insight;interest;Intestines;Inulin;Laboratories;Libraries;Life Style;Magic;Maps;Measurement;Metagenomics;Methods;Microbe;microbiome;microbiota;Microfluidics;microorganism;Molecular Genetics;Mucins;Mus;mutant;novel;Nutrient;Organism;Osmosis;Outcome;personalized medicine;Pharmaceutical Preparations;Phenotype;Phylogenetic Analysis;Physiological;Physiology;Population;Protocols documentation;Research;Research Personnel;resident commensals;Resolution;Resources;Role;Shapes;Sorting;Source;Stress;Study models;System;Technology;Testing;Time;tool;Volatile Fatty Acids;Work

PROJECT_TITLE: A universal pipeline for functional characterization of the human microbiota at a massive scale


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: NATICK

ORG_NAME: ALTEC, INC.

PHR: This project addresses the fundamental mission of NIDCD (National Institute for Deafness and Communication Disorders) to provide novel means of assisting communication for people with severe motor impairments caused by congenital and/or acquired disabilities such as stroke, high-level spinal cord injury, neural degeneration, or neuromuscular disease. Leveraging advances in wearable access technology, which has not been explored sufficiently for AAC users, we are developing MyAACTM, the first AAC device that enables versatile access and automatically learns and customizes a keyboard interface to an individual’s residual motor capabilities. MyAACTM represents a unique AAC device that provides alternative communication access by accommodating the residual motor function of individuals with severe motor impairments for improved societal integration and quality of life.

PI_NAMEs: DE LUCA, GIANLUCA  (contact);VOJTECH, JENNIFER MICHELE

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acquired disability;Address;Algorithms;alternative communication;American;Augmentative and Alternative Communication;automated algorithm;Boston;Brain Stem Infarctions;Calibration;Caregiver support;Caregivers;Cerebral Palsy;Clinical;Collaborations;Communication;communication device;Communication impairment;Communication Methods;Compensation;Computer software;Computers;data exchange;deafness;design;dexterity;disability;Drops;Electromyography;Evaluation;experience;Family;foot;Forehead;Frustration;Genetic Transcription;Gestures;Goals;Guillain Barré Syndrome;Hand;handheld mobile device;Head;Hospitals;improved;Individual;Intuition;Learning;Letters;Life;Maintenance;Manuals;Methods;Mission;Modification;Motor;Motor Activity;motor impairment;Movement;Nerve Degeneration;Neuromuscular Diseases;novel;Participant;Performance;Persons;Phase;point of care;Population;preference;Quality of life;rehabilitation engineering;rehabilitation science;Rehabilitation therapy;Research Personnel;Residual state;Running;Scanning;sensor;Socialization;Speech;Spinal cord injury;Stroke;Surface;Surveys;System;Tablet Computer;Target Populations;Technology;Testing;Time;Traumatic Brain Injury;Universities;usability;user friendly software;visual tracking;wearable device;wireless;wireless communication;Work;Workload

PROJECT_TITLE: Adaptive & Individualized AAC


ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE This project addresses a major unmet clinical need of a potent and safe insulin sensitizer to tackle the increased prevalence of type 2 diabetes. Accomplishing this project will identify first-in-class PPARγ acetylation inhibitors that leverage the insulin-sensitizing properties and improved safety profiles on body weight, heart, bone, and fluid balance for the prevention and better treatment of diabetes.

PI_NAMEs: WANG, WEIDONG  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: absorption;Acetylation;Address;Adipocytes;Adopted;Adverse effects;Affinity;Agonist;analog;Anti-diabetic Drugs;Atherosclerosis;Binding;Binding Proteins;Biological Assay;Biological Availability;Biology;Body fat;Body Weight;bone;bone loss;Cells;Cellular Assay;Chemicals;Clinical;clinical development;comorbidity;cost;Deacetylase;Deacetylation;design;Diabetes Mellitus;Diabetes prevention;diaries;diet-induced obesity;driving force;drug discovery;Drug Kinetics;Drug or chemical Tissue Distribution;Edema;efficacy evaluation;Energy Metabolism;Epidemic;Excretory function;Exhibits;Fluid Balance;Gene Expression;Genes;Genetic;glucose tolerance;Goals;Half-Life;Heart;Heart failure;Heart Hypertrophy;Hormonal;improved;In Vitro;in vivo;in vivo evaluation;inhibitor;Insulin;Insulin Resistance;insulin sensitivity;insulin sensitizing drugs;Knock-in Mouse;Lead;lead candidate;Link;Liquid substance;Metabolic;Metabolic Diseases;Metabolism;mimetics;mouse model;Mus;Names;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Nuclear Receptors;Obese Mice;Obesity;obesity genetics;pandemic disease;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Plasma;Play;Positioning Attribute;Post-Translational Protein Processing;PPAR gamma;pre-clinical;Prevalence;Prevention;Property;prototype;Reporting;Research;retention rate;Safety;side effect;SIRT1 gene;small molecule;Standardization;Structure;Structure-Activity Relationship;systemic toxicity;Testing;Therapeutic;therapeutic target;therapy development;Toxic effect;transcription factor;Treatment Efficacy;Validation;Water;Weight Gain;Work

PROJECT_TITLE: Preclinical Validation of PPARg Acetylation Inhibitors for Diabetes Prevention and Treatment


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: Nashville

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: The bacterial type II topoisomerases, gyrase and topoisomerase IV, are the targets for fluoroquinolones, which are among the most widely prescribed antibacterial drugs worldwide and are ranked by the World Health Organization among the five classes of “highest priority critically important antimicrobials.” Unfortunately, the use of fluoroquinolones is being undercut by a high incidence of target-mediated resistance. Given the crisis in antibacterial resistance and the fact that gyrase and topoisomerase IV are validated antibacterial targets, our goals are to determine the underlying basis for drug action and resistance against these enzymes in purified systems and bacterial cells and to determine the basis for the actions of novel bacterial topoisomerase inhibitors (NBTIs) and spiropyrimidinetriones (SPTs), new agents that target these enzymes and bypass fluoroquinolone resistance.

PI_NAMEs: OSHEROFF, NEIL  (contact)

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: Acinetobacter baumannii;Active Sites;Amino Acids;Anti-Bacterial Agents;antimicrobial;Aspartic Acid;Bacillus anthracis;Bacterial Drug Resistance;bacterial resistance;Binding;Bypass;Cell Death;Cell Death Induction;Cells;cellular targeting;Ciprofloxacin;Clinical;clinical efficacy;Complex;DNA;DNA Damage;DNA Double Strand Break;DNA Maintenance;DNA Topoisomerase IV;Double Effect;drug action;Drug Interactions;Drug resistance;Drug usage;Enzyme Inhibition;Enzymes;Escherichia coli;fluoroquinolone resistance;Fluoroquinolones;Francisella tularensis;Genetic Materials;Genome;Goals;Handedness;Health;Human;In Vitro;in vitro activity;in vivo;Incidence;Ions;Laboratories;Libraries;Ligation;Mediating;member;Metals;Monitor;mutant;Mutation;Mycobacterium tuberculosis;Neisseria gonorrhoeae;Neurofibrillary Tangles;New Agents;novel;Oral;pathogen;Pharmaceutical Preparations;Phase III Clinical Trials;Physiological;Positioning Attribute;Publishing;Research;Resistance;resistance mechanism;Role;Serine;Single-Stranded DNA;Site;Staphylococcus aureus;Structure;Superhelical DNA;System;targeted agent;Topoisomerase II;Topoisomerase Inhibitors;Toxin;Water;World Health Organization

PROJECT_TITLE: Mechanistic Studies of Gyrase/Topoisomerase IV-Targeted Antibacterials

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: NARRATIVE Cells and tissues experience diverse forms of stress, that lead to protein misfolding and aggregation, negatively impacting survival. How stresses like oxidative damage or xenobiotics cause misfolding, and how they are sensed to allow mobilization of appropriate defense countermeasures including protein chaperones with the capacity to block protein aggregation and the formation of amyloid structures are poorly understood. This research proposal aims to elucidate the mechanisms responsible for ensuring proper protein homeostasis in single-cell (yeast) and animals (fruit fly) as a prelude to enabling therapeutic interventions to promote human health.

PI_NAMEs: MORANO, KEVIN ANTHONY (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Alzheimer's Disease;Amyloid;amyloid formation;amyloid structure;Animals;arm;Autophagocytosis;Biochemical;Biological;Biological Models;Buffers;Cell Nucleus;Cells;Cytoplasm;Cytoprotection;Cytosol;Diabetes Mellitus;Disease;Drosophila genus;empowerment;Endoplasmic Reticulum;Ensure;Equilibrium;experience;fly;Future;Glutathione;Goals;Growth;Health;Human;Huntington Disease;Investigation;Link;Mediating;misfolded protein;Molecular Chaperones;multicatalytic endopeptidase complex;Neurodegenerative Disorders;novel;Oxidants;oxidation;Oxidation-Reduction;oxidative damage;Parkinson Disease;Pathway interactions;programs;Proliferating;Property;protein aggregation;protein folding;protein misfolding;Proteins;proteostasis;proteotoxicity;Quality Control;Reactive Oxygen Species;Research Proposals;response;Role;Stress;stressor;System;therapeutic development;Therapeutic Intervention;Tissues;transcription factor;TXN gene;Ubiquitin;Work;Xenobiotics;Yeasts

PROJECT_TITLE: Chaperone-mediated mechanisms of cellular proteostasis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetic Testing;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention;Serious Mental Illness;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: One in three children in the United States will experience an adverse childhood experience (ACE) before adulthood. Pre-natal and early post-natal environments contribute notably to the development of negative psychiatric endophenotypes related to schizophrenia, bipolar disorder, major depression, anxiety disorders, etc. all of which are highly prevalent in the United States. This proposal is aimed at identifying the contextspecific regulatory logic of risk during neurodevelopment, with the translational potential to promote the mitigation of environmental stressors during fetal development and early childhood.

PI_NAMEs: RETALLICK-TOWNSLEY, KAYLA  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Adult;adverse childhood events;Affect;Anorexia Nervosa;Anxiety Disorders;appropriate dose;Architecture;Area;Astrocytes;Atlases;Attention Deficit Disorder;autism spectrum disorder;Awareness;Biological;Biological Assay;Bipolar Disorder;Brain;brain cell;Brain Diseases;causal variant;cell type;cellular development;Child;clinical predictors;Complex;Core Facility;Cues;Data;Data Analyses;Data Set;Dedications;Development;Diagnostic;Disease;disorder risk;Distal;Dorsal;Dose;Drug usage;early childhood;Elements;endophenotype;Enhancers;Environment;Environmental Risk Factor;environmental stressor;experience;Fellowship;fetal;Fetal Development;Funding;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic disorder diagnosis;Genetic Risk;Genetic Transcription;genetic variant;Genomics;Glutamates;Goals;Health;Heritability;High-Throughput Nucleotide Sequencing;Human;human induced pluripotent stem cells;Hydrocortisone;immune activation;improved;in silico;In Vitro;in vitro activity;Inflammation;Inflammatory;insight;Institution;interest;Interleukin-6;late life;Lateral;Leadership;Libraries;Life;Link;Logic;Major Depressive Disorder;Medical;Mental disorders;Mental Health;Mind;Modeling;Molecular;multidisciplinary;Mutagenesis;neurodevelopment;Neurodevelopmental Disorder;Neurons;neuropsychiatric disorder;Neurosciences;Neurotic Disorders;novel;novel therapeutic intervention;offspring;Outcome;Pathology;Pathway interactions;Pattern;Pharmaceutical Preparations;Physiological;Post-Traumatic Stress Disorders;postnatal;Predisposition;Prefrontal Cortex;Pregnancy;prenatal;prenatal influence;prenatal stress;Principal Investigator;programs;promoter;Regulatory Element;Reporter;Research;resilience;response;Risk;risk variant;Schizophrenia;Scholarship;screening;stem cell model;Stress;Symptoms;Techniques;Testing;Therapeutic Intervention;therapeutic target;TNF gene;Toxic effect;Training;Training Programs;trait;transcriptome sequencing;transcriptomics;Translating;translational impact;translational potential;United States;United States National Institutes of Health;Untranslated RNA;Variant;Work

PROJECT_TITLE: Massively Parallel Characterization of Cell-type and Context Specific Regulatory Risk Elements Across Psychiatric Disorders in a Stem Cell Model of Neurodevelopment


ADMINISTERING_IC: HL

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Rehabilitation

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE This study aims to establish the physiological role of a previously unreported soluble Platelet-Derived Growth Factor Receptor-β (sPDGFRβ) that appears to be broadly expressed in healthy tissues. Similar to related soluble growth factor receptors, sPDGFRβ may regulate the bioavailability of a key growth factor that contributes to microvascular stability, with aberrant sPDGFRβ expression associated with vessel dysfunction. The purpose of this study is to advance our understanding of how and where sPDGFRβ may regulate vessel function, with the long-term goal of exploring how sPDGFRβ may be developed as a diagnostic tool and/or a target for bioengineered therapies.

PI_NAMEs: CHAPPELL, JOHN CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Activities of Daily Living;Affinity Chromatography;Alternative Splicing;Alzheimer's Disease;Binding;Biological Assay;Biological Availability;Biological Markers;Biological Process;Biomedical Engineering;Blood;Blood capillaries;Blood Vessels;blood-based biomarker;Brain;brain parenchyma;Capillary Endothelial Cell;Cardiovascular Diseases;cell type;Cells;Cerebrum;confocal imaging;Custom;Data;density;Diagnostic;diagnostic tool;differential expression;Disease;Docking;Drug or chemical Tissue Distribution;Endothelial Cells;Extracellular Matrix;Flow Cytometry;Fluorescence;Functional disorder;Future;Genetic Engineering;Goals;Growth Factor;Growth Factor Receptors;Hand;Heparin;heparin proteoglycan;Hybrids;Immunohistochemistry;In Vitro;in vivo Model;insight;Investigation;Investments;knock-down;Length;Ligands;Maintenance;Malignant Neoplasms;Mediating;Messenger RNA;Microvascular Dysfunction;migration;Modeling;Morphology;Mus;Normal Range;Pathology;PDGFRL gene;Pericytes;Permeability;Physiological;platelet-derived growth factor BB;Platelet-Derived Growth Factor beta Receptor;Proliferating;Protein Isoforms;Proteins;Quantitative Reverse Transcriptase PCR;receptor;Receptor Protein-Tyrosine Kinases;Recombinants;recruit;Regulation;Reporter;Reporting;Research Design;Role;Signal Induction;Signal Transduction;Signaling Protein;Spatial Distribution;spatiotemporal;Specificity;Testing;Therapeutic;therapeutic target;Tissues;Transcript;Variant;vascular bed;Vascular Endothelial Cell;Work

PROJECT_TITLE: A Tissue-Specific Soluble Platelet-Derived Growth Factor Receptor-beta Isoform Retains Functional Capacity

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: CA

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE This project is tightly aligned with the NIH mission by unveiling new molecular and pathogenic mechanisms that account for T cell lymphoma, with a focus on the TET-mediated epigenetic modifications and the RHO GTPase pathway. Our studies will furnish important insights that are immediately relevant to the clinic by elucidating how mutations in TET2 and RHOA cooperate to drive blood cancer. Our discoveries will advance the development of novel therapeutics by targeting abnormal DNA modifications and GTPase activity for the prevention and treatment of blood cancers to benefit millions of patients suffering from leukemia and lymphoma.

PI_NAMEs: HUANG, YUN  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Advanced Development;AKT Signaling Pathway;Animal Model;Automobile Driving;Binding;Biological Assay;Biology;Blood Cells;blood treatment;Cancer Intervention;Caring;CD4 Positive T Lymphocytes;Cell Physiology;Cell Separation;Cells;Chemicals;Clinic;Clinical;clinically relevant;Dimensions;Dioxygenases;Disease;Dissection;DNA;DNA Modification Process;effective therapy;Enzymes;Epigenetic Process;epigenome;epigenome editing;epigenomics;Etiology;Event;exome sequencing;Foundations;FOXO1A gene;Funding;Gene Expression;Gene Modified;Genes;Genetic;Genetic Transcription;Genomic approach;Genomics;Genotype;Goals;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;helicase;Hematologic Neoplasms;hematopoietic differentiation;Hematopoietic Neoplasms;Hematopoietic stem cells;Human;Hybrids;Impairment;innovation;insight;Knock-in;Knowledge;Lesion;leukemia/lymphoma;lymphoid neoplasm;Lymphoma;Lymphomagenesis;Malignant - descriptor;Malignant Neoplasms;Maps;Mature T-Lymphocyte;Mediating;Metabolism;Mission;Modification;Molecular;Molecular Target;Monomeric GTP-Binding Proteins;mouse model;Mus;Mutation;Myelogenous;Natural Killer Cells;new therapeutic target;novel;Oncogenic;optogenetics;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peripheral;peripheral lymphoid organ;Phenotype;Phosphatidylinositols;PIK3CG gene;Pilot Projects;Polymerase;pre-clinical;premalignant;Premalignant Cell;Prevention;Prognosis;promoter;Research;rho;rho GTP-Binding Proteins;RHOA gene;RNA;RNA Helicase;RNA Polymerase II;Rodent Model;Sampling;Signal Pathway;Signal Transduction;Somatic Mutation;Structure;synergism;T-Cell Lymphoma;T-Lymphocyte;targeted treatment;Testing;Therapeutic;tool;Transcriptional Regulation;transcriptome sequencing;Transgenic Mice;tumor;Tumor Burden;tumorigenesis;United States National Institutes of Health

PROJECT_TITLE: Mutational cooperativity in TET2-associated hematological malignancies.

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Head and Spine Injury

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Abnormally increased muscle tone, is a significant dysfunction in stroke, cerebral palsy, spinal cord injury and traumatic brain injury. Electrical nerve block is a promising candidate for producing a reliable, rapid, gradable and reversible motor nerve block. We propose an innovative, non-invasive direct current muscle block, delivered through the skin, that will aid in the rehabilitation of limb movement by reducing spasticity.

PI_NAMEs: VRABEC, TINA LOUISE (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Action Potentials;Acute;Acute Pain;Affect;afferent nerve;autonomic nerve;Axon;Cerebral Palsy;channel blockers;Charge;Chronic;chronic pain;chronic pain relief;Clinical;clinical application;Complication;Contracture;cost;Data;Denervation;design;Development;Devices;Diameter;disability;Disabling;Effectiveness;electric impedance;Electrodes;Electrolytes;Elements;experimental study;flexibility;Functional disorder;Future;Generations;Goals;Histology;Human;In Vitro;in vitro testing;in vivo;in vivo evaluation;Injections;innovation;Interruption;Ion Channel Gating;limb movement;Local Anesthetics;Medical;Methods;Modality;Modeling;Monitor;Motor;Movement;Muscle;Muscle Hypertonia;Muscle Spasticity;Nerve;Nerve Block;nerve damage;Neural Conduction;Neural Inhibition;Neurons;neurotransmission;nonhuman primate;novel;Operative Surgical Procedures;Oral;Oryctolagus cuniculus;Pathologic;Peripheral;peroneal nerve;Pharmaceutical Preparations;pharmacologic;preclinical study;Property;Rattus;Reaction;Recovery;Rehabilitation therapy;Relaxation;response;Rodent;Rodent Model;Safety;safety study;simulation;Site;Skin;skin damage;skin irritation;spasticity;Spinal cord injury;Stroke;Surface;Temperature;Testing;Time;Tissues;Titrations;Translating;Traumatic Brain Injury;voltage;Work

PROJECT_TITLE: Transcutaneous Direct Current Motor Nerve Block for Spasticity

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Burden of Illness;Caregiving Research;Clinical Research;Disability Research;Dystonia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Rare Diseases;Rehabilitation;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Adults with chronic communication (speech) disabilities are at a high risk for social isolation and resulting poorer health outcomes and quality of life. Family members and others who may be assumed to provide support for these patients to enable them to engage in home, social, and work life may be unable to provide the needed accommodations because of the third-party disability they experience as a result of increased burden of care and loss of emotional connection with their loved one with the communication impairment. This project targets reducing social isolation and improving life participation for adults with communication disabilities and their families by examining the reciprocal relationships among participation in daily communication activities, the novel construct of perceived social support for communication provided by family / key communication partners, and the third party disability impact of communication disorders on family / key communication partners for people with speech disabilities due to Parkinson’s disease, laryngeal dystonia, laryngectomy, and oral-pharyngeal cancer.

PI_NAMEs: BAYLOR, CAROLYN RAE (contact)

PROJECT_TERMS: Address;Adult;Advocate;Affect;Attitude;Behavior;Behavioral;biopsychosocial;care burden;care giving burden;Caring;Chronic;Client;Clinical;Communication;Communication Barriers;Communication Disability;Communication impairment;Death Rate;Diagnosis;Disabilities experience;disability;disability impact;Dysarthria;Emotional;Environment;experience;Family;Family member;family support;Foundations;Future;Goals;Health;Healthcare;high risk;Home;Impairment;improved;Influentials;Knowledge;Language;Laryngectomy;Left;Life;lonely individuals;loved ones;Malignant neoplasm of pharynx;Measurement;Measures;Motor;Nature;novel;Oropharyngeal;Outcome;Parkinson Disease;Participant;Partner Communications;Pathologist;patient oriented;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Persons;Physical shape;poor health outcome;Population;Qualitative Research;Quality of life;Recording of previous events;Research;Role;social;social engagement;Social Environment;social influence;Social isolation;Social outcome;Social support;socioenvironmental factor;Spastic Dysphonias;Speech;Survey Methodology;tool;Voice;Voice Disorders;Work;Workplace

PROJECT_TITLE: Reducing social isolation for adults with chronic communication disabilities

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Diffusion MRI is a powerful contrast mechanism sensitive to cortical microstructure and structural connectivity in the brain, yet technical and physiological barriers preclude high spatial resolution diffusion MRI of the medial temporal lobe in Alzheimer’s disease. We will develop high-resolution and high-fidelity diffusion MRI acquisition technology tailored to the medial temporal lobe to overcome these barriers and provide noninvasive diagnostic markers sensitive to very early microstructural and connectivity changes in Alzheimer’s disease.

PI_NAMEs: BILGIC, BERKIN  (contact);HUANG, SUSIE YI

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Address;Aging;Air;Alzheimer's Disease;Alzheimer's disease patient;Anterior;Atrophic;Brain;Brain region;Cells;Clinical Research;Cognitive;combat;connectome;Data;denoising;density;dentate gyrus;diagnostic biomarker;Diffusion;Diffusion Magnetic Resonance Imaging;diffusion weighted;Disease;early detection biomarkers;Early Diagnosis;Echo-Planar Imaging;entorhinal cortex;Fiber;Hippocampal Formation;Hippocampus;Image;imaging biomarker;in vivo;long term memory;Maps;Measurement;Measures;medial temporal lobe;Memory impairment;mild cognitive impairment;millimeter;Modeling;Morphologic artifacts;Motion;motion sensitivity;Neocortex;Nerve Degeneration;Network-based;neural network;Neurites;Neurofibrillary Tangles;neuron loss;neuropathology;neuroprotection;Noise;non-invasive imaging;noninvasive diagnosis;older adult;open source;Parahippocampal Gyrus;Parietal Lobe;Pathologic;Pathology;Pathway interactions;Perforant Pathway;Performance;Physiological;prisma;Protocols documentation;Relaxation;research study;Resolution;Scanning;self supervised learning;Seminal;Senile Plaques;Signal Transduction;structural imaging;Structural Models;Structure;Synapses;tau Proteins;Techniques;Technology;Temporal bone structure;Temporal Lobe;Testing;Thick;Thinness;Time;Tissues;tractography;Translations;Vendor;Visualization;Work

PROJECT_TITLE: Submillimeter resolution diffusion MRI of the medial temporal lobe in the earliest stages of Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-U (81)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Multiple Sclerosis;Neurodegenerative;Neurosciences;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The proposed research is relevant to public health because it focuses on assessing the feasibility and preliminary efficacy of a new proactive physical therapy delivery model that promotes long-term physical activity engagement for persons with multiple sclerosis. The proposed research is relevant to the National Center for Medical Rehabilitation Research’s mission because it evaluates a new window of opportunity for rehabilitative interventions and assesses a rehabilitative strategy involving exercise, behavioral modifications, and outcome measures for persons with multiple sclerosis.

PI_NAMEs: KINNETT-HOPKINS, DOMINIQUE  (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Academy;Accelerometer;Address;Adherence;Adoption;Aerobic Exercise;Aftercare;Age;American;Behavior;Behavior Therapy;Behavioral;Caring;Clinical;Communication;Control Groups;data management;Diagnosis;Disease;efficacy testing;empowerment;Evaluation;Exercise;exercise regimen;exercise training;Fatigue;Feasibility Studies;feasibility trial;Financial cost;follow-up;functional restoration;Goals;Guidelines;Healthcare Systems;implementation evaluation;implementation framework;implementation process;improved;improved outcome;Information Dissemination;Insurance;Insurance Carriers;Intervention;Interview;Knowledge;knowledge integration;Life;Maintenance;Measures;Medical center;Mission;Modeling;moderate-to-vigorous physical activity;Monitor;Morbidity - disease rate;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Neurology;novel;Outcome;Outcome Measure;Ownership;Parkinson Disease;Participant;patient engagement;Patients;Persons;Physical activity;Physical Exercise;Physical Function;physical therapist;Physical therapy;Pilot Projects;pilot trial;Policies;Population;Positioning Attribute;post intervention;prevent;primary outcome;Process;programs;Public Health;Quality Indicator;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;recruit;rehabilitation research;rehabilitation strategy;Rehabilitation therapy;Reporting;Research;Research Project Grants;research study;resistance exercise;Resources;restoration;Safety;Sampling;satisfaction;secondary outcome;Self Efficacy;Service delivery model;skills;Structure;Surveys;symptom management;symptom treatment;symptomatic improvement;Symptoms;Time;Translating;translational approach;treatment effect;United States;uptake;Visit;Waiting Lists;Work

PROJECT_TITLE: Promotion of Exercise for Multiple Sclerosis through Physical Therapy (PromPT)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-G (57)]


ADMINISTERING_IC: HS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE – UCSF E-STaR OVERALL A Learning Health System delivers high quality, safe, and optimally efficient care, at the right time to the right people, optimizing the care delivery system’s performance by generating and acting on meaningful data from the process of care. The UCSF E-STaR Center will speed the integration of interventions/evaluations into practice change, using methodologies that advance and continuously improve health care quality, equity, and patient-centered outcomes, disseminating findings and processes to local and national audiences.

PI_NAMEs: AUERBACH, ANDREW D;GONZALES, RALPH  (contact);WHOOLEY, MARY A

PROGRAM_OFFICER_NAME: GRIFFIOEN, MARI

PROJECT_TITLE: Learning Health System Embedded Scientist Training and Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZHS1 HSR-B (01)]


PI_NAMEs: GONZALES, RALPH  (contact)

PROJECT_TITLE: Learning Health System Embedded Scientist Training and Research Center - Admin Core


PI_NAMEs: SARKAR, URMIMALA  (contact)

PROJECT_TITLE: Learning Health System Embedded Scientist Training and Research Center - REC


PI_NAMEs: AUERBACH, ANDREW D (contact)

PROJECT_TITLE: Learning Health System Embedded Scientist Training and Research Center - RDAC


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: NARRATIVE. Astrocytes contribute to neuronal activity, blood-brain-barrier function, inflammatory response, and more, but how astrocytes change during aging and in age-related neurological disorders is not well understood. Here we report a novel astrocyte phenotype in normal aging, that is exacerbated in the APPNL-G-F mouse model of Alzheimer’s Disease (AD), known as “atypical astrocytes” (AtAs) in which astrocytes lose multiple functional proteins but do not appear to be reactive. In this proposal we will determine the molecular characteristics of AtA, their functional consequences, and the role of vascular dysfunction in driving AtA formation during healthy aging and in a mouse model of AD.

PI_NAMEs: DULLA, CHRIS G (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Age;age related;Aging;aging related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Amino Acid Transporter;aquaporin 4;Area;Astrocytes;Automobile Driving;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;Brain;Buffers;Cells;Characteristics;Data;Development;Disease;Disease Progression;early onset;Electrophysiology (science);Excitatory Amino Acids;extracellular;Extracellular Space;Fluorescence-Activated Cell Sorting;Fluorescent in Situ Hybridization;Functional disorder;Generations;Genetic;GLAST Protein;Glial Fibrillary Acidic Protein;glutamatergic signaling;Glutamates;healthy aging;Hippocampus;Homeostasis;Human;Hypertension;Image;Immunohistochemistry;Impaired cognition;Individual;Inflammation;Inflammatory Response;Label;Link;Mediating;Molecular;Morphology;mouse model;Mus;nano-string;Nervous System Disorder;Neuronal Dysfunction;Neurons;neurotransmission;normal aging;novel;overexpression;Pathology;Phenotype;Potassium;Prefrontal Cortex;Property;Proteins;Publishing;Reporter;Reporting;Risk Factors;Role;senescence;Shapes;SOX9 protein;Structure;Synapses;synaptic function;Testing;tool;transcriptomics;uptake;Vascular Diseases;Viral

PROJECT_TITLE: Atypical astrocytes in aging and Alzheimer's Disease

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Pulmonary disease due to non-tuberculous mycobacteria, including Mycobacterium avium Complex Pulmonary Disease (MAC-PD), is increasing worldwide, and treatment remains challenging because a) some patients will improve without antibiotics, while b) not all patients that receive antibiotics will recover. We will leverage existing clinical data, together with newly collected clinical, immune and drug data, to predict which patients are likely to get better with or without antibiotics by using a combination of computational tools (machine learning (top-down) and mechanistic (bottom-up) models). This work will help us understand how bacteria, host immune response and antibiotics work together to drive infection outcomes; but also provide predictive tools that will improve clinical management and treatment outcomes for MAC-PD patients by determining patient-specific risks for different treatment strategies.

PI_NAMEs: ESCALANTE, PATRICIO  (contact);PENNINGTON, KELLY M;PIENAAR, ELSJE

PROGRAM_OFFICER_NAME: LAUGHON, BARBARA E

PROJECT_TERMS: Age;Algorithms;Antibiotic Therapy;Antibiotics;antigen-specific T cells;Antigens;Automobile Driving;Bacteria;Biological;Body mass index;Bronchoalveolar Lavage;Characteristics;classification algorithm;Clinical;Clinical Data;Clinical Management;Clinical Treatment;cohort;Complex;Computer Models;Computer Simulation;computerized tools;Data;data integration;Data Set;Disease Progression;disorder risk;drug intolerance;Drug Kinetics;Drug resistance;Florida;Goals;Guidelines;Hygiene;Immune;Immune response;Immunologics;improved;Indiana;ineffective therapies;Infection;innovation;insight;interdisciplinary approach;Knowledge;Lesion;Liquid substance;Lung;Lung Diseases;lung lesion;Machine Learning;Minnesota;Modeling;multidisciplinary;Mycobacterium avium;Mycobacterium avium Complex;non-tuberculosis mycobacteria;non-tuberculous mycobacterial infection;novel;Outcome;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacology;precision medicine;Prediction of Response to Therapy;predictive signature;predictive tools;Predisposition;Prevalence;progression risk;prospective;Prospective cohort;random forest;Regimen;Research;response;Retrospective cohort;Risk;risk prediction;Serum;sex;side effect;simulation;Site;stem;System;Systems Biology;T cell response;T-Cell Activation;Testing;Tissues;tool;Training;Translating;treatment duration;Treatment Failure;Treatment outcome;Treatment Protocols;treatment response;treatment risk;treatment strategy;Uncertainty;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Systems biology to predict progression and treatment response in M avium complex pulmonary disease

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Cardiovascular disease (CVD) is the main cause of death in older adults in the US and the burden of aging- associated CVD is expected to increase as the percentage of the older population steadily grows. A key characteristic of vascular aging is arterial stiffening, which is a causal factor and independent prognosticator of cardiovascular morbidity and mortality. This project will determine the molecular mechanisms underlying arterial stiffening in aging and, for the first time, examine the efficacy of SGLT2 inhibition in reversing aging- associated arterial stiffening.

PI_NAMEs: MANRIQUE ACEVEDO, CAMILA MARGARITA  (contact);MARTINEZ-LEMUS, LUIS A;PADILLA, JAUME

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Actins;Address;Age Years;Aging;aging related;aging reversal;arterial stiffness;Arteries;Blood Vessels;Cardiovascular Diseases;cardiovascular effects;Cardiovascular system;Cause of Death;Characteristics;Clinical Trials;cofilin;cohort;Collagen;depolymerization;Deposition;design;Development;Diabetes Mellitus;Down-Regulation;efficacy evaluation;efficacy testing;Event;experimental study;Extracellular Matrix;F-Actin;Family member;Female;gain of function;genetic manipulation;Glucose;Goals;Heart failure;Homologous Gene;in vivo;inhibitor;Kidney;Knowledge;LIM Domain Kinase 1;loss of function;male;Mediating;Microfilaments;Molecular;Monomeric GTP-Binding Proteins;Morbidity - disease rate;mortality;mouse model;older adult;Older Population;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phosphorylation;polymerization;Polymers;prevent;Protein Dephosphorylation;Protein Kinase;Publishing;randomized placebo-controlled clinical trial;Reducing Agents;Research;rho;Role;Smooth Muscle Myocytes;Sodium;Stress Fibers;symporter;targeted treatment;Testing;Therapeutic;therapeutic target;Time;Vascular remodeling;Vascular Smooth Muscle

PROJECT_TITLE: SGLT2 inhibition as a therapeutic strategy to reverse arterial stiffening in aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-R (02)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Rare Diseases;Sleep Research

PHR: Project Narrative: The proposed research is relevant to public health because narcolepsy, a REM sleep-related disorder, affects 1 in 2000 individuals in the US and there are significant health and financial costs associated with this disease. Understanding the neural mechanisms that underlie narcolepsy, particularly how monoaminergic and limbic systems contribute to excessive sleepiness and abnormal motor control across states, is necessary to identify new targets and approaches to treating narcolepsy, as well as sleep disorders more broadly. Thus, this proposal is relevant to the part of NIH’s mission that pertains to fostering fundamental basic science discoveries, using innovative approaches, with the goal of ultimately improving health.

PI_NAMEs: TOTH, BRANDON ANTHONY (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Affect;Amygdaloid structure;Animals;Arousal;Attenuated;Basic Science;Behavior;Brain;Brain region;Brain Stem;Cataplexy;Cell Nucleus;Chronic;Coupled;Development;Disease;Dopamine;dopamine system;Drowsiness;effective therapy;Electroencephalography;Emotional;Equilibrium;Excessive Daytime Sleepiness;experience;Fiber;Financial cost;Fluorescence;Fostering;Frequencies;Genetic;Goals;Health;Health Care Costs;Human;hypocretin;improved;in vivo;Individual;innovation;insight;interdisciplinary approach;knockout animal;Label;Lateral;Limbic System;locus ceruleus structure;Mediating;midbrain central gray substance;Mission;Modernization;monoamine;motor control;mouse model;Mus;Muscle;Muscle Tonus;Narcolepsy;neural;neuromechanism;Neurons;noradrenergic;Norepinephrine;norepinephrine system;novel strategies;Nucleus Accumbens;Obstructive Sleep Apnea;optogenetics;Patients;Persons;pharmacologic;Photometry;Pontine structure;positive emotional state;Positive Valence;Prevalence;Public Health;rapid eye movement;Regulation;REM Sleep;REM Sleep Behavior Disorder;Research;response;Role;sensor;side effect;Signal Transduction;Sleep;Sleep Disorders;Sleep disturbances;sleep regulation;Societies;Source;Stimulus;Symptoms;System;Tegmentum Mesencephali;Testing;United States National Institutes of Health;Wakefulness

PROJECT_TITLE: Monoaminergic and limbic systems underlying narcolepsy-cataplexy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


ORG_DEPT: OTHER BASIC SCIENCES

PHR: Project Narrative The University of Michigan (U-M) Department of Learning Health Sciences (DLHS) proposes to establish an embedded Learning Health System (LHS) scientist training and research (“MEL-STaR”) center to support the experiential training of embedded learning health system scientists. Future LHS scientists will focus on principles of patient centeredness to improve patient outcomes and experience, health system operations, quality, and health equity as they prepare for careers through embedded experiences in settings where LHS activity is ongoing such as within U-M departments, statewide Collaborative Quality Initiatives, VA centers for quality improvement, networks of federally qualified health centers and community mental health centers, and national research networks (e.g. PCORnet).

PI_NAMEs: FRIEDMAN, CHARLES P (contact);PIATT, GRETCHEN A

PROJECT_TITLE: Michigan Embedded LHS Scientist Training and Research (MEL-STaR) Center


PI_NAMEs: FRIEDMAN, CHARLES P (contact)

PROJECT_TITLE: Administrative Core


PI_NAMEs: PIATT, GRETCHEN A (contact)

PROJECT_TITLE: Research Education Core


PI_NAMEs: KILBOURNE, AMY M (contact)

PROJECT_TITLE: Research and Data Analysis Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE  Both the psychotic-like symptoms and the motivational deficits characteristic of schizophrenia, including its risk states, may be related to impairments in the processing of salience or importance. Psychotic-like symptoms may result from aberrant salience, which is giving undue importance to neutral events or stimuli, whereas motivational deficits may result from blunted adaptive salience, which is not giving enough importance to what may be good or pleasurable. In this proposal we will study, over time, young people at risk for schizophrenia, in whom both types of symptoms are evolving, to determine the extent to which forms of “salience processing” may be related to their symptoms and function.

PI_NAMEs: CORCORAN, CHERYL MARY;WALTZ, JAMES A (contact);WOLF, DANIEL H

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: Adolescent and Young Adult;Anhedonia;Antipsychotic Agents;Behavior;Behavioral;Behavioral Mechanisms;Brain region;Characteristics;Chronic;Chronic Disease;Clinical;Clinical Data;clinical high risk for psychosis;clinical risk;Clinical Treatment;Cognitive deficits;cohort;Collaborations;Collection;comorbidity;Computer Models;Data;Decision Making;Delusions;Dimensions;disabling symptom;effective therapy;Equation;Evaluation;Event;Evidence based intervention;expectation;experience;Functional disorder;Functional Magnetic Resonance Imaging;functional outcomes;Future;Goals;Hallucinations;Heterogeneity;high risk;high risk population;Image;Impairment;improved;Individual;Individual Differences;Investigation;Learning;Link;Literature;Longitudinal Studies;Measures;Modeling;Morbidity - disease rate;Motivation;Nature;Negative Finding;Negative Valence;neural circuit;neural correlate;neurobehavioral;neuromechanism;novel;Outcome;Pattern;Perceptual disturbance;Pharmaceutical Preparations;pleasure;Populations at Risk;preventive intervention;Procedures;Process;Prognosis;prospective;Psychiatry;psychologic;Psychological reinforcement;Psychoses;psychosis risk;psychotic;response;Rest;Rewards;Risk;Sample Size;Sampling;Schizophrenia;schizophrenia risk;schizophrenia spectrum disorder;Severities;Site;Stimulus;Symptoms;Syndrome;Teenagers;therapy development;Thinking;Time;Uncertainty;Work;young adult;Youth

PROJECT_TITLE: Reward, Salience and Value Processing in Youths at Risk for Psychosis: The RSVP Study

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project narrative The purpose of the Learning Health System Embedded Scientist Training and Research (LHS E-STaR) of the North (LEaRN) Center is to create a dynamic training and research environment for scholars to learn in, and meaningfully improve, healthcare systems within and outside of Minnesota.

PI_NAMEs: BEEBE, TIMOTHY  (contact);MELTON-MEAUX, GENEVIEVE B

PROJECT_TITLE: Learning Health System Embedded Scientist Training and Research (LHS E-STaR) of theNorth (LEaRN)


PI_NAMEs: BEEBE, TIMOTHY  (contact)


PI_NAMEs: SHIPPEE, NATHAN D (contact)


PI_NAMEs: MELTON-MEAUX, GENEVIEVE B (contact)

PROJECT_TITLE: Research Data Analysis Core


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Chromatin context is a critical determinant of all DNA transactions that is frequently perturbed in cancer cells. Genome-scale approaches to study chromatin are largely based on the detection of a single protein or molecular feature, resulting in one-dimensional data sets that fail to uncover the functional diversity of the target protein. We will establish a versatile and broadly applicable technique for the genome-wide mapping of complex chromatin features and will apply this method to advance the epigenomic characterization of pathological RNA:DNA hybrids, a poorly understood hallmark of many cancer genomes.

PI_NAMEs: OBERDOERFFER, PHILIPP  (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: analog;Antibodies;assay development;Basic Cancer Research;Binding;Binding Proteins;biochemical tools;Biological;Biological Assay;Biology;Biotin;cancer cell;cancer genome;cancer type;Cells;Chromatin;chromatin immunoprecipitation;combinatorial;Complex;Data Set;Detection;DNA;DNA biosynthesis;DNA Damage;DNA mapping;DNA replication fork;epigenomics;Excision;experience;Foundations;Gene Expression Regulation;Genes;Genome;genome integrity;Genome Mappings;genome-wide;genome-wide analysis;Genomic Instability;Genomics;Goals;Histones;Hybrids;Image;imaging detection;Immunoprecipitation;improved;In Situ;Individual;interest;Label;Ligation;Maintenance;Malignant - descriptor;Malignant Neoplasms;Maps;Methodology;Methods;Molecular;next generation sequencing;novel;nucleic acid structure;Nucleotides;Pathologic;Physiological;Poison;Positioning Attribute;Proteins;replication stress;Research Personnel;response;ribonuclease H1;Ribonucleotides;RNA;Role;Signal Transduction;Single-Stranded DNA;Source;targeted cancer therapy;Techniques;tool;treatment response;Visualization;Work

PROJECT_TITLE: Proximity epigenomics for context-specific analysis of complex chromatin features

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-D (O1)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Social Determinants of Health

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative The 2024 Environmental Science: Water Gordon Research Conference will feature a program of leading researchers whose work strives to improve water quality and protect public health. The conference sessions will include topics on (i) challenges and opportunities in managing global pollutants, (ii) environmental toxicology and toxins, (iii) environmentally persistent chemicals and materials, and (iv) environmental justice issues related to water. The unique and immersive format of this meeting provides an ideal setting to foster cross fertilization and stimulate new ideas amongst researchers from multiple disciplines and diverse backgrounds, as well as between early-career and established career stages. 1

PI_NAMEs: REMUCAL, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: TROTTIER, BRITTANY

PROJECT_TERMS: Academia;Address;Atmosphere;Biological;Biology;carbon emissions;career;Chemicals;Chemistry;climate change;climate impact;community building;community engagement;Complex;Country;Dedications;Discipline;diversity and inclusion;Ecosystem;Educational process of instructing;Engineering;Ensure;Environment;Environmental Impact;environmental justice;Environmental Policy;Environmental Science;environmental toxicology;Evaluation;experience;Fellowship;Fertilization;Fostering;Funding;Funding Mechanisms;Goals;Government;graduate student;Health;Hour;Human;improved;Industry;innovation;Laboratories;Learning;Link;Measurement;meetings;Nature;novel strategies;Outcome;Participant;pathogen;pollutant;Postdoctoral Fellow;posters;programs;Public Health;Research;Research Personnel;Resources;Schools;Science;Scientist;Senior Scientist;Series;Services;Site;Students;success;Surveys;symposium;System;Technology;Toxic Environmental Substances;Toxicology;Training;Trustees;Underrepresented Populations;Water;Water Purification;water quality;Work

PROJECT_TITLE: 2024 Environmental Sciences: Water Gordon Research Conference

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 ARL-W (13)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Public Alzheimer’s disease (AD) is a common chronic neurodegenerative disorder regarded as a highly significant public health issue. Neuroinflammation accompanies AD pathology, but the etiology for this disorder is not yet fully understood and, no treatment is available that can reverse or stop the neurodegenerative process in AD. In this study, we will apply ultra-sensitive genomic technologies for tracking immunogenetic and epigenomic profiles in AD patients and AD model animals that may provide paradigm-shifting findings and identify new types of biological markers and targets for the effective treatments of AD.

PI_NAMEs: ROGAEV, EVGENY I (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;adaptive immunity;Aging;aging brain;aging process;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's Disease Pathway;Alzheimer's disease patient;Alzheimer's disease risk;Animal Disease Models;Antigen Presentation;Antigen Targeting;antigen-specific T cells;Antigens;Attenuated;B-Lymphocytes;Biological;Biological Assay;Biological Markers;Brain;brain cell;Brain Mapping;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Shape;cell type;Cells;Chromatin;Chromosome Mapping;Chronic;Clinical;cohort;Collection;Complex;Data;Disease;Dissection;effective therapy;Elderly;Elements;Epigenetic Process;epigenomics;Etiology;Event;Gene Expression;Genes;Genetic;Genetic study;Genomic approach;genomic profiling;Genomics;Goals;Haplotypes;Histocompatibility Antigens Class II;Human;human disease;humoral immunity deficiency;Immune;immune cell infiltrate;Immune Response Genes;Immune system;Immunogenetics;Impaired cognition;Individual;individual variation;Infiltration;Inflammation;innovation;Link;Major Histocompatibility Complex;Major Histocompatibility Complex Gene;Microglia;Molecular;Molecular Genetics;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neuroimmune;neuroinflammation;neuron loss;Neurons;non-demented;novel;Pathogenesis;Pathology;peripheral blood;Population;Process;Property;Public Health;Reporting;Research;Resolution;Risk Factors;Sampling;Shapes;Specific qualifier value;Specimen;Synapses;T cell infiltration;T-Cell Depletion;T-Cell Receptor Genes;T-cell receptor repertoire;T-Lymphocyte;Technology;transcriptome;Transgenic Mice;Up-Regulation;γδ T cells

PROJECT_TITLE: Neuroimmune Genomic Profiling of Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: WINCHESTER

ORG_NAME: HOPEFUL AGING LLC

PHR: PROJECT NARRATIVE There are currently 6.7 million Americans living with dementia and, without significant breakthroughs, this figure will double to 12.7 million by 2050 (Rajan et al., 2021). Dementia interferes with a person’s ability to function by impairing memory, reasoning, judgment, language, initiation, and socialization, leading to many unfortunate outcomes, including social isolation / withdrawal (Semple, et al., 1982; Alexander & Geschwind, 1984; Liu, Gauthier, & Gauthier, 1991, Social Care Institute, 2019). With this in mind, the proposed Phase II study will involve the further development and testing of a multi-faceted software application called “Building Relationships using Artificial Intelligence and Nostalgia” or BRAIN.

PI_NAMEs: SKRAJNER, MICHAEL JOHN (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Adherence;Affect;Aggressive behavior;Agitation;Alzheimer's Disease;American;Anxiety;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;base;Behavior;Behavioral;Behavioral Symptoms;Brain;Caring;Clinical Trials;Cluster randomized trial;Code;Cognition;Cognitive;Communication;Computer software;dashboard;Data;Dementia;dementia care;Development;digital technology;digital treatment;Ensure;Evaluation;Exhibits;Family member;Feedback;Fostering;Functional disorder;Generations;Goals;Health care facility;Home;improved;indexing;Individual;interest;Intervention;Japanese;Japanese Population;Judgment;Language;Libraries;Link;Long-Term Care;Marketing;member;Memory impairment;model building;Monitor;Outcome;Paper;Participant;Persons;Phase;phase 1 designs;phase 2 study;Phase I Clinical Trials;Privatization;Process;programs;Protocols documentation;prototype;psychological symptom;psychosocial;Quality of life;Recommendation;Research;response;Sample Size;satisfaction;Site;social;Social isolation;Socialization;standard care;Structure;success;System;Testing;Time;tool;Training;trait;usability;Withdrawal

PROJECT_TITLE: The BRAIN App: Building Relationships using Artificial Intelligence and Nostalgia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (10)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Data Science;Genetics;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Pulmonary Hypertension;Tobacco;Tobacco Smoke and Health

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Pulmonary hypertension (PH) is a heterogeneous high mortality condition arising as a primary condition as well as a complication of COPD, heart failure, and clots in the lung. In carrying out the research outlined in the following proposal, we plan to develop and apply computational methods based on deep learning to quantify the structural and functional changes that can be seen using CT scans in the lung of patients with PH arising as a comorbidly of COPD. The result of this work will help us develop non-invasive ways of detecting PH in smokers, improve our understanding of the disease, and potentially enable better, targeted therapies.

PI_NAMEs: NARDELLI, PIETRO  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Advisory Committees;Affect;Algorithms;Arteries;Artificial Intelligence;Award;Biological;biomarker identification;Blood coagulation;Blood Vessels;Blood Volume;career;career development;Case/Control Studies;Categories;Characteristics;Chest;chest computed tomography;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Research;clinically relevant;Coagulation Process;cohort;Collaborations;comorbidity;Complication;Computational algorithm;Computing Methodologies;Data;Data Set;deep learning;Defect;Detection;Diagnostic;Dimensions;Disease;Disease Marker;Disease Progression;Distal;Doctor of Philosophy;Early Diagnosis;endophenotype;Etiology;Evolution;Fractals;Funding;Genetic;genetic epidemiology;Genetic Predisposition to Disease;genetic risk factor;Genetic study;genetic variant;genome wide association study;Goals;Heart failure;Heterogeneity;Image;Image Analysis;improved;innovation;Intervention;Iodine;Lung;Maps;Measures;Medical Imaging;Mentors;Methodology;Methods;Molecular;Monitor;Morphology;mortality;mortality risk;Multicenter Studies;multiscale data;Muscle;National Heart, Lung, and Blood Institute;novel;novel marker;Outcome;Pathologic;Pathway interactions;Patients;Performance;Perfusion;Peripheral;Persons;Pharmaceutical Preparations;Phenotype;predicting response;Process;Publishing;pulmonary arterial pressure;Pulmonary Hypertension;pulmonary vascular disorder;pulmonary vascular remodeling;Pulmonary vessels;Pulmonology;quantitative imaging;radiologist;rare variant;Research;Research Design;research study;Resources;response;Risk;risk prediction;Scanning;screening;secondary analysis;Secondary to;Severities;Severity of illness;Smoke;Smoker;Structure-Activity Relationship;Study Subject;success;System;targeted treatment;Techniques;Testing;Therapeutic;tool;Translational Research;Vascular remodeling;Veins;Western World;Work;World Health Organization;X-Ray Computed Tomography

PROJECT_TITLE: Structural and Funcional Vascular Phenotyping in Smokers with Pulmonary Hypertension using Artificial Intelligence

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (OA)]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Reverse cholesterol transport is a key mechanism preventing atherosclerotic heart disease. We are investigating the genetic and molecular basis of what drives reverse cholesterol transport to better identify novel strategies to reduce heart disease risk overall, and specifically, in South Asians. This project will train junior investigators on using patient-oriented research to improve heart health.

PI_NAMEs: ROHATGI, ANAND KUMAR (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: adjudication;Affect;Anti-Inflammatory Agents;Antiatherogenic;Asian population;atheroprotective;Atherosclerosis;atherosclerosis risk;Award;Bangladesh;Blood Vessels;Canada;Cardiac health;Cardiology;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;career;Carotid Artery Plaques;Cause of Death;Cholesterol;Clinic;Clinical;clinically relevant;Code;cohort;Complement;coronary artery calcium;Coronary heart disease;Deposition;Development;Diabetes Mellitus;Diet;Diffuse;Disease;Educational workshop;Epidemiology;Ethnic Population;Event;Excision;Exhibits;exome sequencing;experience;Faculty;Fatty acid glycerol esters;Fellowship;Functional disorder;Funding;Future;Genetic;genetic association;genetic variant;genome-wide;Genomics;Genotype;Grant;Heart;heart disease risk;Heart failure;Heterogeneity;High Density Lipoproteins;high risk;Human;Impairment;improved;India;Individual;Industry;Inflammation;insight;Insulin Resistance;Internal Medicine;K-Series Research Career Programs;Leadership;Life Style;Link;lipid metabolism;Lipids;Lipoproteins;Measures;Mediator;Medical center;meetings;Mendelian randomization;Mentors;Mentorship;Metabolism;metabolomics;Molecular;Myocardial Infarction;National Heart, Lung, and Blood Institute;Nepal;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;novel strategies;Pakistan;Paper;particle;Particle Size;Pathway interactions;patient oriented research;Phenotype;Plasma;Population;Positioning Attribute;Postdoctoral Fellow;premature;prevent;Preventive;Process;professor;programs;prospective;protein complex;Proteins;Proteomics;Publishing;Research;Research Personnel;reverse cholesterol transport;Risk Factors;Risk Marker;risk prediction;Role;South Asian;Sri Lanka;Surface;targeted treatment;tenure track;Training;trait;translational research program;translational scientist;Triglycerides;United States National Institutes of Health;Variant;Woman;Work

PROJECT_TITLE: Mentoring Patient-Oriented Research in Deep Lipid Phenotyping for Cardiovascular Disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (OA)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Activity;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Despite significant time and money spent on post-stroke rehabilitation, stroke survivors are left with reduced walking capacity and significant disability. After stroke, individuals must relearn movements that have been disrupted due to damage to the brain, therefore, enhancing motor learning is critical to improving the rehabilitation of walking after stroke. In this project we will examine how individual factors influence motor learning after stroke and use this information to personalize post-stroke rehabilitation.

PI_NAMEs: REISMAN, DARCY S. (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Address;Adult;Aerobic Exercise;Affect;Area;Attention;Awareness;Behavioral;Brain;Categories;Cerebellum;Chronic;chronic stroke;clinical practice;Cognition;Cognitive;Cognitive deficits;cognitive function;Complex;Coupling;Cues;Data;Demographic Factors;design;disability;Exercise;exercise intensity;Funding;Goals;Impairment;improved;Individual;Intervention;Learning;Left;Location;motor learning;Movement;Neurologic;neurophysiology;novel;Patients;Pattern;post stroke;Prefrontal Cortex;Process;Quality of life;Recovery;Rehabilitation therapy;Research;Research Personnel;Resources;Role;Short-Term Memory;Stroke;stroke rehabilitation;stroke survivor;Techniques;Time;Training;treadmill;Upper Extremity;verbal;visual feedback;Visuospatial;Walking;walking rehabilitation;Work

PROJECT_TITLE: Behavioral and Neurophysiologic Process of Locomotor Learning After Stroke

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Orphan Drug;Rare Diseases

ORG_NAME: SHASQI, INC.

PHR: Narrative Cancer incidence and mortality are growing worldwide and there is an urgent need for new treatment options for patients with aggressive forms of cancer. Current treatments include the use of cytotoxic agents such as doxorubicin (Dox) to promote tumor regression, which unfortunately after prolonged use can result in severe and sometimes life-threatening side effects. Shasqi has developed a novel drug product, SQ3370, that serves to inhibit tumor growth and protection against tumor rechallenge, while exhibiting enhanced tolerability and reduced systemic side effects in comparison to conventional Dox treatment.

PI_NAMEs: MEJIA ONETO, JOSE M (contact)

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: Acceleration;Accounting;Animals;Anthracycline;Attenuated;Biological;Biological Factors;Biological Markers;Biopolymers;Bone Marrow Suppression;cancer diagnosis;cancer type;Cancerous;Cardiotoxicity;Cessation of life;Characteristics;Chemistry;chemotherapy;Clinical Trials;cohort;Cyclooctenes;cytotoxic;Cytotoxic agent;Data;design;Development;Diagnosis;Disease;Dose;Doxorubicin;Drug Kinetics;Enrollment;Evaluation;Exhibits;first-in-human;Future;immune activation;immune checkpoint blockade;immunogenic cell death;improved;In Situ;Incidence;Injectable;Injections;Investigational New Drug Application;Knowledge;lead candidate;Life;Malignant Neoplasms;Methods;mortality;neoplastic;novel therapeutics;objective response rate;Oxygen;Patients;Persons;Pharmaceutical Preparations;Phase;phase I trial;Phase II Clinical Trials;phase II trial;Poisoning;pre-clinical;preclinical study;protein expression;Reaction;Recommendation;Refractory;Relapse;Safety;safety assessment;Sarcoma;side effect;Site;Sodium Hyaluronate;Soft tissue sarcoma;Solid Neoplasm;Survival Rate;systemic toxicity;Tissues;Toxicity Attenuation;treatment and outcome;tumor;tumor growth;Tumor Promotion;United States Food and Drug Administration

PROJECT_TITLE: Assessing the safety and efficacy of SQ3370 in a phase 1b dose-expansion cohort at the recommended Phase 2 dose in patients with advanced sarcoma


ORG_CITY: PORTLAND

ORG_NAME: NATIONAL UNIVERSITY OF NATURAL MEDICINE

ORG_STATE: OR

PHR: Project Narrative The objective of this program is to implement, evaluate, and disseminate rigorous, nutrition focused, evidence-based nutrition research skills training and mentored research experiences for trainees and health professionals in both conventional and integrative nutritional science. While numerous successful models of evidence-based health care skills training exist, these programs are not sufficient for nutrition trainees who conduct systematic reviews and who apply nutrition in clinical practice. Evidence-based Nutrition & Research Guidance (ENER-G) will lead to robust research and clinical practice skills across the Evidence Lifecycle that supports improvement in the management of diabetes, obesity, and digestive diseases.

PI_NAMEs: ALLRED, CLINTON D;ZWICKEY, HEATHER LEA (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Accreditation;Address;Adherence;Clinical;clinical practice;Cognitive;cohort;Collaborations;college;Communities;Continuing Education;Country;Data;Decision Making;design;diabetes management;Diabetes Mellitus;dietary;Dietary Intervention;Digestive System Disorders;Disease;Dissemination and Implementation;Dose;Education;Educational process of instructing;Educational workshop;Eligibility Determination;Ethicists;evidence base;experience;Faculty;Goals;graduate student;hands on research;Health Care Research;Health Professional;Healthcare;improved;Individual;innovation;Institution;Leadership;lectures;Life Cycle Stages;Manuscripts;Medicine;Mentors;Meta-Analysis;Methodology;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;North Carolina;Nutrient;nutrition;nutrition education;nutritional approach;Nutritional Science;Nutritional Study;Obesity;Observational Study;Patients;Peer Review;Philosophy;Physicians;Policies;Population;programs;Protocols documentation;Publications;Publishing;Randomized, Controlled Trials;Reproducibility;Research;Research Personnel;response;Review Literature;Science;Scientist;Series;skill acquisition;skills;skills training;sound;Students;systematic review;Texas;Training;Training Programs;Universities

PROJECT_TITLE: Evidence-based Nutrition Education and Research Guidance (ENER-G)

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE  Conditions such as osteoporosis, osteoarthritis, osteomyelitis; developmental skeletal abnormalities; and malignancies such as multiple myeloma and breast cancer, negatively affect the skeleton. There is an ongoing need to better understand the causes of these diseases to support the development of more effective and well- tolerated therapies. Comprehensive analyses of the molecular changes that contribute to these conditions may lead to the development of such therapies.

PI_NAMEs: O'BRIEN, CHARLES A (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Achievement;Affect;Animals;Arkansas;Benchmarking;Bioinformatics;Biomedical Research;bone;bone imaging;Centers of Research Excellence;Clinical Investigator;Collaborations;CRISPR interference;Degenerative polyarthritis;Development;disability;Disease;effective therapy;Environment;experience;Faculty;Fertilization in Vitro;Functional disorder;Funding;Gene Expression Profiling;Gene Modified;genetic manipulation;Genetic Models;Goals;Grant;Health;Health Care Costs;Histology;Image;in vivo;innovative technologies;Institution;Lead;loss of function;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Medical;Mentors;Molecular;Molecular Analysis;mouse model;Multiple Myeloma;Mus;Musculoskeletal;Musculoskeletal Diseases;Musculoskeletal System;National Institute of General Medical Sciences;novel;novel strategies;Osteomyelitis;Osteoporosis;Patients;Phase;Pilot Projects;Play;Population;Productivity;programs;recruit;Research;Research Infrastructure;Research Personnel;Research Support;Resources;Sampling;Science;Scientist;Services;skeletal abnormality;Skeleton;sperm cryopreservation;Structure;success;synergism;Technology;Universities;web-based tool

PROJECT_TITLE: Center for Musculoskeletal Disease Research (CMDR)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Advisory Committees;Affect;Aging;Agreement;Applications Grants;Area;Arkansas;Bioinformatics;Biology;Biomedical Research;bone imaging;Bone remodeling;Bone Tissue;Cellular biology;Centers of Research Excellence;Collaborations;Communication;Data Set;Dedications;Department chair;Development;Development Plans;Disease;Doctor of Philosophy;effective therapy;Endocrinology;Evaluation;experience;Extramural Activities;Faculty;Fostering;Foundations;Functional disorder;Funding;Genetic Models;Goals;Growth;Histology;Human;Infrastructure;Institution;Leadership;Learning;Medical;member;Mentors;Mentorship;Molecular;Musculoskeletal;Musculoskeletal Diseases;Musculoskeletal System;Names;operation;Osteoblasts;Osteocytes;peer;Peer Review;Phase;Physiology;Pilot Projects;Productivity;programs;Publications;Publishing;recruit;Recruitment Activity;Research;Research Infrastructure;Research Personnel;Research Project Grants;Science;Scientist;Services;skeletal;Structure;success;Teacher Professional Development;United States National Institutes of Health;Universities;Work


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics

PI_NAMEs: FU, QIANG  (contact)

PROJECT_TERMS: Affect;Arkansas;Bioinformatics;Biomechanics;bone imaging;Businesses;Cell Physiology;cell type;Centers of Research Excellence;Child;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Communities;Core Facility;CRISPR interference;Dedications;Derivation procedure;design;Development;Disease;disease-causing mutation;DNA;Educational workshop;effective therapy;Evaluation;experience;Fertilization in Vitro;Functional disorder;gain of function;gene editing technology;gene function;Gene Modified;Generations;Genes;genetic manipulation;Genetic Models;Genetically Modified Animals;Goals;Healthcare Systems;Histology;Human Resources;human tissue;Injections;Institution;Leadership;Literature;loss of function;Maintenance;Medical;meetings;member;Modeling;Modification;Molecular;Mus;Musculoskeletal;Musculoskeletal Diseases;novel;novel strategies;novel therapeutic intervention;Pathologic Processes;Phase;Pilot Projects;Play;Process;Research;Research Institute;Research Personnel;Research Project Grants;Resources;Role;Science;Service delivery model;Services;Signal Pathway;Skeleton;skill acquisition;Specificity;sperm cryopreservation;success;synergism;System;Technology;Testing;tool;Training;Training and Education;Transgenic Mice;Transgenic Organisms;Universities;Update;Veterans

PROJECT_TITLE: Genetic Models Core


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research

PI_NAMEs: XIONG, JINHU  (contact)

PROJECT_TERMS: Animals;Arkansas;biobank;Bioinformatics;Biology;biomechanical test;Biomechanics;bone;bone imaging;Bone Marrow;Bone Marrow Cells;Bone Tissue;Clinical;Clinical Data;Collaborations;Decalcification;design;Disease;DNA;Doctor of Philosophy;Educational Activities;Educational workshop;Endocrinology;Ensure;Equipment;experience;experimental study;Faculty;Frozen Sections;Gene Expression;Genetic;Goals;Hindlimb Suspension;Hip region structure;hip replacement arthroplasty;Histologic;Histology;Human;Human Resources;human tissue;Image;In Situ;in vivo;Institution;investigator training;Knowledge;Laboratories;long bone;Maintenance;Measurement;Medical;member;Mesenchymal Stem Cells;Metastatic Neoplasm to the Bone;Microtomy;Molecular;mouse model;Mus;Musculoskeletal;Musculoskeletal Diseases;new technology;novel;Operative Surgical Procedures;Orthopedics;Osteogenesis;Osteoporosis;Paraffin Embedding;Pathologic;Patient Care;Patients;Phase;Physiological;Plasma;Plastic Embedding;Process;programs;Research;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Resources;RNA;Sampling;Science;Serum;Services;skeletal;skeletal disorder;Skeleton;spine bone structure;Stains;success;System;Testing;Thick;tibia;Tissue Sample;Tissues;Training;Training and Education;transcriptomics;Translational Research;Universities;Urine;Work

PROJECT_TITLE: Histology, Biomechanics, and Human Tissue Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: DELGADO-CALLE, JESUS  (contact)

PROJECT_TERMS: analytical tool;Animal Model;Animals;Architecture;Arkansas;Bioinformatics;Biology;bioluminescence imaging;Biomechanics;Body Composition;bone;bone imaging;bone mass;bone strength;Cellular biology;Centers of Research Excellence;Core Facility;cortical bone;Data;design;Disease;Doctor of Philosophy;Dual-Energy X-Ray Absorptiometry;Educational Activities;Educational workshop;Ensure;Equipment;experience;experimental study;Faculty;Finite Element Analysis;fluorescence imaging;Foundations;Genetic;Genetic Models;Geometry;Goals;Histologic;Histology;Human Resources;human tissue;Image;imaging approach;imaging modality;imaging study;in vivo;investigator training;Knowledge;Laboratories;longitudinal analysis;Malignant Bone Neoplasm;Measurement;Medical;member;Mentors;mineralization;Modernization;Molecular;mouse model;Musculoskeletal;Musculoskeletal Diseases;musculoskeletal imaging;Musculoskeletal System;new technology;novel;Orthopedics;Osteomyelitis;Osteoporosis;Pathogenesis;Phase;Phenotype;Physiology;Porosity;Process;Productivity;programs;Research;Research Personnel;Research Project Grants;Resolution;Resources;Roentgen Rays;routine imaging;Sampling;Scanning Electron Microscopy;Science;Services;skeletal;Skeleton;substantia spongiosa;success;System;Technology;Tissue imaging;Tissues;tomography;Training;Training and Education;two photon microscopy;Universities;Visualization;Work

PROJECT_TITLE: Bone Imaging Core


ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project narrative The goal of this project is to collect continuous glucose monitoring data in a healthy community-based sample to determine whether patterns identified in the rise and fall of glucose levels throughout the day can help predict risk of developing diabetes mellitus. Through linking patterns of dynamic glucose levels with diet and physical activity (among other factors like genetics, bacteria in the gut, and the prevalence of cardiovascular disease), this project may also lead to new discoveries that will tailor and target prevention of diabetes mellitus.

PI_NAMEs: SPARTANO, NICOLE L (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, JEAN M

PROJECT_TERMS: Adult;Age;American;Awareness;Behavior;Biochemical;Biological Markers;Blood;Blood Glucose;Blood specimen;Body mass index;Body System;cardiorespiratory fitness;Cardiovascular Diseases;Cardiovascular system;Categories;Characteristics;Clinical;Clinical Markers;cohort;Communities;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Cross-Sectional Studies;Data;deep learning model;Development;diabetes management;Diabetes Mellitus;Diabetes prevention;diabetes risk;Diagnosis;Diet;Dietary Practices;Endocrinologist;Epidemiology;Exhibits;falls;Family history of;Fasting;fasting glucose;fasting plasma glucose;Fingers;follow up assessment;follow-up;Framingham Heart Study;Functional disorder;Future;Generations;Genetic;Glucose;glycemic control;Glycosylated hemoglobin A;Goals;gut bacteria;gut microbiome;Health;Health Technology;high risk;Hypoglycemia;improved;Individual;Insulin;Insulin-Dependent Diabetes Mellitus;interstitial;Life Style;Link;Managed Care;Measurement;Measures;Metabolic dysfunction;mHealth;Modification;Monitor;monitoring device;multi-ethnic;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Participant;Patient Self-Report;Patients;Pattern;Pharmacologic Substance;Physical activity;polygenic risk score;Population;Prediabetes syndrome;Prevalence;Publishing;Recording of previous events;recruit;Research Personnel;response;Risk;risk prediction;Sampling;Technology;Time;tool;Woman

PROJECT_TITLE: Continuous glucose monitoring: determinants and prediction of diabetes mellitus development in the Framingham Heart Study

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Skin Cancer

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative  The quest for newer and more effective ways of treating cancer has now led to an extensive focus on the involvement of the immune system and its capacity to recognize and engage tumor cells. In the proposed research we plan to improve the therapeutic efficacy of several known HDAC6 inhibitors (HDAC6i) in order to identify drug-like compounds that are best able to reduce the expression of negative immune check-point molecules. We believe that this HDAC approach will allow for the restoration of immune surveillance mechanisms in cancer cells, especially when the HDAC6i are combined with immunotherapeutic agents such as anti-PD-1 blocking antibodies, thereby leading to improved anti-tumor immune responses.

PI_NAMEs: BARINKA, CYRIL ;VILLAGRA, ALEJANDRO V (contact);WARDROP, DUNCAN JOHN

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Acetylation;Address;Adjuvant;Advanced Malignant Neoplasm;Anti-Inflammatory Agents;anti-PD-1;anti-tumor immune response;Antineoplastic Agents;Attention;Autoimmunity;Biological Assay;Blocking Antibodies;cancer cell;cancer immunotherapy;cancer therapy;Cardiac;CD8B1 gene;Cell Therapy;Cells;Characteristics;Chronic;Clinical;Combination immunotherapy;Combined Modality Therapy;CTLA4 gene;cytokine;cytotoxic;Cytotoxic agent;cytotoxicity;Deacetylase;design;Development;Distant;Down-Regulation;drug-like compound;Effectiveness;Epigenetic Process;Event;Generations;Genetic;genotoxicity;Goals;Graft Rejection;Grant;HDAC6 gene;Histone Deacetylase;Histone Deacetylase Inhibitor;Immune;immune checkpoint;immune checkpoint blockade;Immune system;immune-related adverse events;Immunity;Immunologic Surveillance;Immunologics;immunoregulation;Immunotherapeutic agent;improved;In complete remission;In Vitro;in vivo;Infiltration;Inflammation Mediators;Inflammatory;inhibitor;innovation;interest;Interleukin-10;Isoenzymes;Knowledge;Life Expectancy;Lung;Macrophage;Malignant Neoplasms;Marketing;Measures;Mediating;Mediator;Melanoma;Melanoma Tumor;Metabolic;Metastatic Melanoma;Methods;Modality;Modeling;molecular modeling;Molecular Target;Mus;Neoplasm Metastasis;neoplastic cell;Neurodegenerative Disorders;novel;offspring;patient derived xenograft model;Patients;Pharmaceutical Chemistry;pharmacologic;Phenotype;Population;Positioning Attribute;pre-clinical;Process;programmed cell death ligand 1;programmed cell death protein 1;programs;Property;Proteins;Radiation therapy;rational design;Rattus;receptor;Reporting;Research;Resistance;restoration;Role;scale up;side effect;Surface;targeted agent;Testing;Toxic effect;Translating;translational study;Treatment Efficacy;Tubulin;tumor;Tumor Antigens;tumor growth;Tumor Immunity;Tumor-associated macrophages;Validation;Vorinostat;Work

PROJECT_TITLE: Development of selective HDAC6 inhibitors to improve cancer immunotherapy

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Gene Therapy;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Monitoring of tumor progression and/or response to therapy in pathologically indistinguishable (yet biologically and clinically diverse) cohorts of prostate cancer patients remains a substantial unmet need, so here we seek to integrate an adaptive theranostic gene therapy-based approach using highly engineered phage-AAV chimeric vectors to specifically deliver both an imaging and therapeutic agent. Novel tumor targeting vectors will be available for potential evaluation in first-in-human studies. This work addresses an unmet need in prostate cancer and, if successful, it will ultimately lead to a blueprint towards translational applications in an accelerated framework.

PI_NAMEs: ARAP, WADIH ;LIBUTTI, STEVEN K.;PASQUALINI, RENATA  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;advanced prostate cancer;Adverse event;Animal Model;Antibodies;Atlases;Bacteriophages;biobank;Bioinformatics;Biological;Biometry;Biotechnology;cancer genomics;cancer imaging;Cancer Institute of New Jersey;Cancer Patient;Candidate Disease Gene;Canis familiaris;Cell surface;Cells;Clinical;Clinical Trials;CMV promoter;cohort;Consent;cost effective;Data;Dependovirus;design;Disease Outcome;Disease Progression;Dose;DU145;Engineering;Evaluation;first-in-human;Ganciclovir;Gene Expression;Gene Expression Profiling;gene therapy;Genes;genetic element;Genetic Screening;Genetic Transcription;Genome;glucose uptake;glucose-regulated proteins;Growth;GRP78 gene;Homing;HSV-Tk Gene;Human;Hybrids;Image;imaging agent;imaging genetics;Immunohistochemistry;In Vitro;in vitro activity;in vivo;Individual;interleukin-11 receptor;Intravenous;intravenous administration;Lead;Libraries;Ligands;Liver;LNCaP;Malignant neoplasm of prostate;manufacture;Mediating;Metastatic Prostate Cancer;Methodology;Molecular Genetics;Molecular Profiling;Molecular Target;Monitor;Mus;Neoplasm Metastasis;neoplastic cell;non-invasive imaging;novel;osteogenic;overexpression;particle;Pathologic;patient derived xenograft model;Patients;PC3 cell line;Peptides;PET/CT scan;Phage Display;phage vector;Phase;Phenotype;Plasmids;Pre-Clinical Model;prediction algorithm;Prodrugs;promoter;Property;prostate cancer cell;prostate cancer cell line;prostate cancer model;prostate cancer progression;Protein Tyrosine Kinase;Radiolabeled;Rattus;receptor;Reporter;Reporting;Sampling;screening;Simplexvirus;Site;Spleen;success;suicide gene;System;targeted delivery;targeted imaging;Technology;Testing;The Cancer Genome Atlas;theranostics;Therapeutic Agents;Thymidine Kinase;transcriptome;transgene delivery;Transgenes;transgenic suicide gene;Translating;translational applications;treatment response;tumor;tumor growth;tumor metabolism;tumor progression;VCaP;vector;Virus;Work;X-Ray Computed Tomography

PROJECT_TITLE: Designing a transcriptome-based, targeted theranostic platform for prostate cancer