NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Dissemination and Implementation Research;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Telehealth

ORG_CITY: GREENVILLE

ORG_NAME: EAST CAROLINA UNIVERSITY

PHR: PROJECT NARRATIVE The public health significance in this study lies in its potential to develop an improved understanding of how to efficiently improve depressive symptoms among adolescent and young adult cancer survivors (AYACS). The findings from this study could result in a scalable and low-cost intervention that enhances self-management of depressive symptoms in this population. Ultimately, this could lead to improved quality of life, increased adherence to medical recommendations, and reductions in healthcare costs associated with cancer recurrence, comorbidities, and premature death among AYACS.

PI_NAMEs: MURPHY, KARLY MARY (contact)

PROGRAM_OFFICER_NAME: EVERSON, NICOLE MARIE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adolescent and Young Adult;Adolescent and young adult cancer patients;Age;age group;arm;associated symptom;Award;Behavior Therapy;Behavioral;Breast Cancer survivor;Businesses;cancer recurrence;Cancer Survivor;career;career development;Cessation of life;child bearing;Child Rearing;Childbirth;Cognitive;comorbidity;Conduct Clinical Trials;cost;Data;depressive symptoms;design;Development;Dissemination and Implementation;dissemination science;Education;Educational workshop;effective intervention;effectiveness/implementation trial;efficacious intervention;efficacy testing;Engineering;Ensure;Evaluation;evidence base;Evidence based intervention;experience;experimental study;Feedback;Future;General Population;Genetic;Goals;Health Care Costs;health care service utilization;Hour;implementation science;improved;Incidence;Individual;innovation;Intervention;intervention cost;intervention effect;Interview;Knowledge;Laboratories;Malignant Neoplasms;Marriage;Medical;Mental Depression;Mentors;Methodology;mHealth;mhealth interventions;Mindfulness Training;Mobile Health Application;mortality risk;multiphase optimization strategy;National Cancer Institute;Oncology;Outcome;Participant;peer;peer support;Persons;Phase;physical symptom;pilot test;Population;preference;premature;Preparation;Prevalence;prevent;Procedures;Process;prototype;Provider;psychosocial;Public Health;Quality of life;Recommendation;remote delivery;Reporting;Research;Research Personnel;Research Priority;Resources;Sampling;Schools;Science;Self Management;Site Visit;skills;Technology;Testing;Training;Treatment/Psychosocial Effects;usability;user centered design;Work

PROJECT_TITLE: iManageAYA: Preparation and Optimization of a mHealth Intervention for Managing Depressive Symptoms in Adolescent and Young adult Cancer Survivors

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Adolescent and young adult (AYA) breast cancer survivors experience substantial symptoms and have unmet concerns in survivorship. In the proposed multi-site RCT, we will test the efficacy of YES, a novel mHealth self-management intervention designed to address the needs of AYA breast cancer survivors vs. usual care. We hope YES will reduce diverse survivors’ symptoms and concerns and improve their quality of life.

PI_NAMEs: NAUGHTON, MICHELLE J.;PARTRIDGE, ANN H (contact)

PROGRAM_OFFICER_NAME: ADAMS, LYNN S

PROJECT_TERMS: Academic Medical Centers;active method;Acute;acute symptom;Address;Adherence;adjuvant endocrine therapy;Adolescent and Young Adult;Adult;aggressive breast cancer;Anxiety;Attention;Body Image;breast cancer diagnosis;Breast Cancer Patient;Breast Cancer survivor;Cancer Survivor;cancer therapy;Case Study;Characteristics;chemotherapy;Child Rearing;Clinic;Clinical;comparison intervention;coping;Dana-Farber Cancer Institute;design;Diagnosis;Disease;Distress;Economics;Education;efficacy evaluation;efficacy testing;electronic patient reported outcomes;Emotional;empowerment;ethnic diversity;experience;expressive writing;falls;Family Planning;Fatigue;Fertility;Fright;Genetic;Geography;Health behavior;health related quality of life;Healthcare Systems;Hot flushes;improved;Incidence;Internet;Intervention;Life;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediator;Medical;Medical center;Mental Depression;mHealth;mhealth interventions;mHealth self-management;Modeling;Monitor;mortality;multi-component intervention;Musculoskeletal;Newly Diagnosed;novel;Occupational;Ohio;older women;Online Systems;Outcome;Participant;Patients;Personal Satisfaction;Phase;Population;Population Heterogeneity;primary outcome;psychosocial;Psychosocial Assessment and Care;Quality of life;racial diversity;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recurrence;reduce symptoms;Reporting;Research;Resources;Risk Reduction;Rural;Self Management;Sexuality;Site;skills;Sleep Disorders;sociodemographics;Stress;Survivors;survivorship;Symptom Burden;symptom management;Symptoms;System;Technology;Testing;theories;therapy design;Time;tool;treatment as usual;Treatment Efficacy;United States;Universities;women's diagnosis;young woman

PROJECT_TITLE: A web-based patient-reported symptom monitoring and self-management portal for adolescent and young adult breast cancer survivors


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Infectious Diseases;Networking and Information Technology R&D (NITRD);Rare Diseases;Telehealth

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Trachoma is the leading infectious cause of blindness in the world. This project aims to develop a mobile software application to enhance trachoma monitoring activities by allowing eye photography and integration of visual acuity and refractive error assessment. The mobile application will be field-tested and validated in diverse settings in Peru to ensure broad generalizability.

PI_NAMEs: KEENAN, JEREMY DAVID (contact);LESCANO, ANDRES G

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3D Print;Address;Adopted;Affect;Anterior;Area;automated algorithm;Blindness;California;Cellular Phone;Certification;Child;Chlamydia trachomatis;Clinical;Collaborations;Communities;Computer software;Cornea;Data;Data Collection;data platform;Development;Diagnosis;Diagnostic tests;Ensure;experience;Eye;feasibility testing;field study;fighting;flexibility;Foundations;Goals;Health;Health Personnel;Health Resources;Health Surveys;Hospitals;Human;Human Resources;imaging Segmentation;Individual;Lighting;Location;mobile application;Modality;Modeling;Monitor;neglected tropical diseases;ophthalmic examination;Pan American Health Organization;Participant;Persons;Peru;Photography;population based;Printing;programs;Public Health;Questionnaires;Recommendation;Refractive Errors;remote communities;remote grading;Research;Research Personnel;Resource-limited setting;sample collection;Sampling;San Francisco;Sensitivity and Specificity;Structure;success;Surveys;System;Telemedicine;Testing;tool;Trachoma;Universities;Update;uptake;user-friendly;validation studies;Variant;Vision Screening;Visual Acuity;Work;World Health Organization

PROJECT_TITLE: Integrating smartphone photography for trachoma, smartphone visual acuity assessment, and mobile autorefraction to enhance community-based public health monitoring

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Disability Research;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: IMPACTIV, INC.

ORG_STATE: GA

PHR: Vivo is a novel resistance training exercise technology platform for older adults that offers a technology and programming solution to the limitations of impersonal training programs in the highly popular digital fitness space. Vivo will allow users to monitor and track behavioral, physiological and psychological progress in real time, and access social network functionality to promote immediate and enduring social support to reinforce the progress from strength training. The technology platform will optimize adherence by leveraging naturally occurring social support systems as Vivo users exercise in real time with a live trainer, family members and teammates.

PI_NAMEs: LEVITAN, ERIC  (contact);STARR, KATHRYN N

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Accountability;Adherence;Adult;Affect;Age;aging in place;arm;Behavioral;Benchmarking;Body Weight;Certification;Chronic Disease;Client;Clinical Trials;Cognition;Cognitive;cognitive task;commercialization;Communities;Computer software;Couples;Databases;design;digital;effectiveness evaluation;Electronic Mail;Elements;Equilibrium;evidence base;Exercise;exercise program;Exertion;experience;fall risk;Family;Family member;Feedback;fitness;Friends;Glucose;Glycosylated hemoglobin A;Goals;Health;healthy aging;Hour;improved;in vivo;Independent Living;Individual;innovation;Internet;Joints;Knee;Location;Lower Extremity;Marketing;Measures;member;mobile application;Monitor;Motivation;Motor;Movement;Muscle;muscle form;Muscle function;Muscular Atrophy;Non-Insulin-Dependent Diabetes Mellitus;novel;older adult;Outcome;pandemic disease;Participant;Performance;Persons;Phase;Physical Function;Physiological;Pilot Projects;Prediabetes syndrome;prevent;primary outcome;prototype;psychologic;Quality of life;resistance exercise;Risk Reduction;Sampling;sarcopenia;satisfaction;secondary outcome;sedentary;Silver;Small Business Innovation Research Grant;social engagement;Social Network;Social support;Specific qualifier value;strength training;success;Supervision;Support System;symposium;System;technological innovation;Technology;technology platform;Testing;Thinness;Time;Training;Training Programs;usability;virtual;Waiting Lists;walking speed;Woman;Work;young adult

PROJECT_TITLE: Improving physical function and quality of life in older adults with prediabetes utilizing interactive small-group resistance training through video conference technology


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Pediatric;Prevention;Substance Misuse;Substance Misuse Prevention;Tobacco

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Nicotine vaping has risen sharply among U.S. adolescents over the past decade. This pilot/feasibility study will set the stage for a larger efficacy trial of a school-based intervention to reduce nicotine vaping. In this program, high school students work with researchers to develop and deliver the program to middle school students. The program includes narrative videos produced by high school students that convey vaping prevention messages, which are delivered in the context of classroom discussions led by high school students that incorporate known determinants of substance use resistance. The program includes a text message campaign implemented by high school students for middle school students.

PI_NAMEs: ASDIGIAN, NANCY ;CRANE, LORI A. (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: academic standard;acceptability and feasibility;Address;Administrator;Adolescent;adolescent health;Adoption;Adult;age group;Attitude;Behavior;Behavior Therapy;Behavioral;Benchmarking;cancer risk;Cardiovascular system;Cluster randomized trial;Collaborations;Colorado;combustible cigarette;Communication;Communities;community based participatory research;coping;Coping Skills;Data Collection;design;Development;Disease;Educational Curriculum;Effectiveness;efficacy outcomes;efficacy testing;efficacy trial;Environment;evidence base;Exposure to;Feasibility Studies;feasibility testing;Foundations;Funding;Future;Goals;Health;Health behavior;Health Promotion;high school;High School Student;innovation;Intervention;intervention delivery;junior high school;Knowledge;Measures;Methods;Middle School Student;Mission;multidisciplinary;Nature;nicotine cessation;nicotine use;Outcome;Parents;peer;Pilot Projects;pilot test;Positioning Attribute;positive youth development;Predisposition;Preparation;pressure;Prevalence;prevent;Prevention;Prevention program;programs;Protocols documentation;Qualifying;Random Allocation;Randomized;randomized trial;Randomized, Controlled Trials;Research;Research Personnel;Resistance;Rest;Risk;role model;School Teachers;Schools;Secondary Schools;Self Efficacy;skill acquisition;skills;skin cancer prevention;Social Change;social norm;Specific qualifier value;Statistical Data Interpretation;statistics;stress management;Student Selections;Students;substance use;substance use prevention;teacher;Teacher Professional Development;Testing;Text Messaging;theories;therapy development;Treatment Efficacy;vaping;vaping nicotine;Work;Youth

PROJECT_TITLE: Pilot and Feasibility Testing of a Peer-led Program to Prevent Youth Nicotine Vaping: The YES-CAN! Program

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Data Science;Mental Health;Neurosciences;Precision Medicine

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE In response to NOSI (NOT-MH-21-175) this proposal leverages multiple large datasets and sophisticated machine learning approaches to address how symptoms of mood, anxiety, and stress, collectively characterized as `anxious misery,' relate to the altered integration of functional brain regions (or networks) across adolescence and adulthood and in relation to treatment response. Multimodal neuroimaging and clinical and cognitive data collected from four Connectomes Related to Human Disease (CRHD) projects, the Human Connectome (HCP) Aging and Development Lifespan projects, and the Adolescent Brain Cognitive Development (ABCD) projects, including 2,187 people, will be analyzed in a unified manner with data-driven methods to understand the relationships between symptoms and brain networks across individuals. Project outcomes will provide a more unified understanding of brain dysfunction in people with different types of anxious misery symptoms and are expected to guide future efforts to provide more effective treatments tailored to specific people.

PI_NAMEs: BIJSTERBOSCH, JANINE DIANE;NARR, KATHERINE L;SHELINE, YVETTE I (contact);WHITFIELD-GABRIELI, SUSAN ;WILLIAMS, LEANNE

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent patient;Adult;Aftercare;Age;Aging;Anhedonia;anti-depressive agents;Anxiety;anxious;associated symptom;biobank;Brain;brain dysfunction;Brain imaging;Brain region;Categories;Chronic;Clinical;Clinical Data;clinical phenotype;Cognition;Cognitive;cognitive development;Collaborations;Communities;Computational Technique;computerized data processing;connectome;connectome data;Data;data harmonization;data modalities;Data Set;density;Development;Diagnosis;Diagnostic;Diffusion;dimension reduction;Dimensions;Disease;Dissection;effective therapy;Emotional;experience;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Heterogeneity;Human;human disease;Image;imaging modality;Individual;individualized medicine;Infusion procedures;interest;Investigation;Ketamine;large datasets;life span;Link;Machine Learning;Magnetic Resonance Imaging;Maps;Measures;Mental disorders;mental function;Methods;Modeling;mood symptom;multidimensional data;multimodal data;Multimodal Imaging;multimodal neuroimaging;multimodality;National Institute of Mental Health;network dysfunction;neural;Noise;novel;Outcome;Outcome Study;Participant;personalized intervention;Persons;Phenotype;precision medicine;Process;Protocols documentation;Psychopathology;Public Health;Research;Research Personnel;response;Rest;rumination;Sampling;secondary analysis;Severities;Sleep Deprivation;Strategic Planning;Stream;Stress;Structure;Subgroup;Symptoms;Treatment outcome;treatment response;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: HCP-2.0: Ascertaining Network Mechanisms and Analytics of Emotional Dysfunction (HARMONY)

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE This project is a collaborative initiative between US researchers and Lao public health officials to determine the efficacy of a novel mHealth intervention for smoking cessation among Lao patients. The proposed research is relevant to public health because it is expected to advance mHealth applications in tobacco-cessation treatment in low- and middle-income settings and subsequently reduce tobacco-related morbidities and mortality. The mHealth intervention is also affordable and scalable and thus is appropriate for widespread adoption in low- and middle-income countries.

PI_NAMEs: BUI, THANH C. (contact)

PROGRAM_OFFICER_NAME: PEARLMAN, PAUL C

PROJECT_TERMS: Abstinence;Address;Adoption;Adult;Adult women;Applications Grants;Behavior Therapy;Biochemical;brief advice;Cambodia;Cambodian;Cellular Phone;Cigarette;Clinics and Hospitals;Collaborations;Communication;Confidence Intervals;Control Groups;cost effective;Country;Data;Developed Countries;Development;Ecological momentary assessment;Educational workshop;efficacy evaluation;Enrollment;Evaluation;follow-up;Future;global health;Goals;Health;health care service;Health Promotion;Health Technology;Hospitals;Image;Income;Influentials;Inservice Training;insight;Institution;Intervention;knowledge base;Language;Laos;low and middle-income countries;Manuscripts;men;mHealth;mhealth interventions;mobile computing;Mobile Health Application;Morbidity - disease rate;mortality;nicotine replacement;novel;Outcome;Participant;Patient Self-Report;Patients;personalized intervention;personalized medicine;Persons;Phase;Pilot Projects;pilot test;Preparation;Prevalence;programs;Proliferating;Province;Public Health;Publishing;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Relative Risks;Reporting;Research;Research Methodology;Research Personnel;secondary outcome;self help;sex;Smoker;smoking cessation;Smoking Cessation Intervention;smoking prevalence;social culture;standard care;support network;Surveys;Technology;text messaging intervention;Tobacco;tobacco cessation intervention;tobacco control;Tobacco smoke;Tobacco use;Tobacco Use Cessation;tool;Training;treatment group;treatment program;Wireless Technology;World Health Organization;Writing

PROJECT_TITLE: Mobile Health Technology for Personalized Tobacco Cessation Support in Laos


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Networking and Information Technology R&D (NITRD)

ORG_CITY: LITTLE ROCK

ORG_NAME: NEPHROPATHOLOGY ASSOCIATES

ORG_STATE: AR

PHR: Project Narrative  Enrolling clinical trials relies on a range of manual processes and requires timely communication with clinicians to avoid losing patients to follow-up. Arkana Laboratories has developed a mobile app, Arkana Connect™ which provides nephrologists with pathology reports, replacing antiquated manual reporting systems like fax machines. The company now proposes a Direct to Phase II SBIR program to develop automated clinical trial enrollment feature on the Arkana Connect App to provide trial sponsors with a more automated, efficient, and timely means of enrolling trials for kidney disease research.

PI_NAMEs: LARSEN, CHRISTOPHER P (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Address;Affect;Automation;Benchmarking;Biological Markers;Biopsy;Clinical;clinical trial enrollment;Clinical Trials;cohort;Communication;cost;Data;Databases;Development;Diagnostic;digital;digital platform;Disease;Effectiveness;efficacy evaluation;efficacy testing;Elements;Eligibility Determination;Engineering;Enrollment;Ensure;Evaluation;Exclusion Criteria;expectation;experience;field study;follow-up;Geographic Locations;Goals;Improve Access;improved;inclusion criteria;Infrastructure;innovation;interest;Kidney;Kidney Diseases;Laboratories;Lesion;Letters;Manuals;Marketing;Methods;mobile application;Nephrology;new technology;Notification;Pathologist;Pathology;Pathology Report;Pathway interactions;Patient Monitoring;patient population;patient privacy;Patient Recruitments;Patient Selection;Patients;Persons;Pharmaceutical Preparations;Phase;Physicians;Positioning Attribute;precision medicine clinical trials;Process;programs;provider communication;Randomized, Controlled Trials;rare condition;Rare Diseases;recruit;Regulation;remediation;Reporting;Research;rural area;Schedule;screening;Signs and Symptoms;Small Business Innovation Research Grant;Software Validation;Standardization;Stratification;success;System;Technology;technology development;Telefacsimile;Testing;Text;therapeutic development;tool;trial enrollment;underserved community;United States;Update;Validation;validation studies

PROJECT_TITLE: A proprietary digital platform for precision patient identification and enrollment of clinical trials for rare kidney diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-J(10)B]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Pediatric

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Enteroviruses cause a wide spectrum of acute disease, ranging from mild upper respiratory illness to aseptic meningitis, encephalitis, and acute flaccid paralysis. In addition to acute infections, enteroviruses, especially coxsackieviruses of the B group, have also been linked to severe myocarditis and type 1 diabetes mellitus. This study will investigate the mechanisms of entry beginning with receptor recognition by coxsackievirus B3 since these critical first steps set in motion events that promote host entry as well as initiating conserved conformational changes to the virus capsid that are necessary for release of the viral genome.

PI_NAMEs: HAFENSTEIN, SUSAN  (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Acute;Acute Disease;acute infection;adenovirus receptor;Anti-viral Agents;Area;Aseptic Meningitis;Binding;Binding Sites;Biochemical;Biological;Capsid;CAR receptor;Cells;Classification;Collaborations;Communicable Diseases;Complement;Coxsackie B Viruses;Coxsackie Viruses;cross reactivity;Cryoelectron Microscopy;Data Collection;Drug Design;Drug Targeting;Encephalitis;endosome membrane;Enterovirus;Epitopes;Event;Family;Family Picornaviridae;Funding;Genome;Goals;Grant;Growth;Hour;Human;human pathogen;Human poliovirus;Hydrophobicity;In Situ;innovation;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Link;Lipids;live cell imaging;Maps;Modeling;Molecular;Molecular Conformation;Motion;Mutation;Myocarditis;nanodisk;Pancreatitis;Paralysed;particle;Pathogenicity;Pediatric Hospitals;Peptides;Philadelphia;Preparation;Process;Productivity;Proline;Proteins;Protocols documentation;receptor;receptor binding;reconstruction;Resolution;respiratory;RNA;RNA Viruses;Sampling;Sequence Alignment;Site;Specificity;Structure;Test Result;Testing;tomography;Viral Genome;Virus;Work

PROJECT_TITLE: Mechanisms of Enterovirus Entry

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy;Prostate Cancer;Skin Cancer;Urologic Diseases

ORG_CITY: MOUNT PLEASANT

ORG_NAME: LIPO-IMMUNO TECH, LLC

ORG_STATE: SC

PHR: NARRATIVE Adoptive transfer of T cells that can recognize tumor and cause tumor cell death is a promising approach and has gained momentum after novel anti-tumor T cells could be engineered by viral transductions of tumor reactive T cell receptor (TCR), or chimeric antigen receptors (CAR). However, many confounding factors as susceptibility to immunosuppression, or T cell’s inability to persist and undergo activation induced cell death due to chronic antigen stimulation in a tumor microenvironment remains. In this application, we propose to generate clinical grade metabolically enhanced Tumor Infiltrating Lymphoytes (meTILs) based on our published methodology in Cell Metabolism. Successful completion of this Phase II application will support this approach where targeting immunometabolism to program TILs could be used in future trials to treat cancer patients.

PI_NAMEs: MEHROTRA, SHIKHAR  (contact)

PROGRAM_OFFICER_NAME: BOZZA, WILLIAM PATRICK

PROJECT_TERMS: Adopted;Adoptive Cell Transfers;Adoptive Transfer;Affinity;Antigens;Appearance;B lymphoid malignancy;Cancer Patient;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Death;Cell Death Induction;Cells;Cellular Metabolic Process;chimeric antigen receptor;Chronic;Clinical;commercialization;cost;cytokine;cytotoxic;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Dependence;design;Dose;effector T cell;efficacy testing;engineered T cells;Engineering;Engraftment;Epitopes;exhaustion;Exhibits;feasibility testing;FOXP3 gene;Future;Generations;Genetic Engineering;Glutamine;Goals;Helper-Inducer T-Lymphocyte;Human;Hybrids;IL17 gene;IL2 gene;immunogenic;Immunosuppression;Immunotherapy;immunotherapy clinical trials;improved;in vivo;in vivo Model;Infiltration;Infusion procedures;Interferon Type II;Interleukin-15;interleukin-21;Investigational Drugs;Investigational New Drug Application;Lead;Logistics;Lytic;Malignant neoplasm of prostate;Malignant Neoplasms;Melanoma;Melanoma Tumor;Memory;Metabolic;metabolic phenotype;Metabolic stress;Metastatic breast cancer;Methodology;Methods;Mitochondria;Molecular Biology;Mutate;neoantigens;neoplastic cell;novel;Nutrient;Pathway interactions;patient derived xenograft model;Patients;Phase;phase 1 study;Phase I Clinical Trials;Phase I/II Clinical Trial;Phenotype;PPBP gene;preclinical study;Predisposition;Primary Neoplasm;programs;Prostatic Neoplasms;Protocols documentation;Publications;Publishing;Regulatory T-Lymphocyte;Reporting;Research;Resources;response;senescence;Solid Neoplasm;stemness;T cell therapy;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;TC1 Cell;Testing;Th1 Cells;Time;TNF gene;transdifferentiation;tumor;Tumor Antigens;Tumor Escape;Tumor Expansion;tumor growth;tumor microenvironment;Tumor Suppression;tumor xenograft;Tumor-Infiltrating Lymphocytes;United States Food and Drug Administration;Variant;Viral;Woman

PROJECT_TITLE: Programming Metabolically Fit TILs for Immunotherapy


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Project Narrative Music training can change brain structure and function in non-musician older adults age 60 and over. The goal of our project is to examine whether a music improvisation training intervention for older adults with and without mild cognitive impairment can improve cognition and brain function and facilitate late-life engagement in cognitively challenging activities.

PI_NAMEs: JOHNSON, JULENE K (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;Affect;Age;Aging;Alzheimer's disease related dementia;arm;Attention;attentional control;Behavior;behavior change;Behavioral;Behavioral Mechanisms;Biological Assay;Brain;Brain imaging;Cognition;Cognitive;cognitive control;cognitive function;comparison control;Complex;cost;Creativeness;Data;Dementia;Educational Intervention;Emotions;executive function;experience;flexibility;Generations;Goals;Health;Health behavior;Impaired cognition;improved;Informal Social Control;innovation;instrument;Intervention;intervention effect;Language;late life;Lateral;Learning;Limb structure;Link;Maintenance;Measures;Memory;Methods;mild cognitive impairment;modifiable risk;Monitor;Motor;multimodality;Music;Music Therapy;Nature;neural;neural patterning;Neuronal Plasticity;novel;older adult;Outcome;Patient Self-Report;Phase;Pilot Projects;Play;pre-clinical;processing speed;psychosocial;psychosocial wellbeing;Randomized;randomized trial;Reading;Research;resilience;Risk;Risk Factors;Self Efficacy;Short-Term Memory;Site;Structure;Techniques;Testing;Thinking;Training;Training Technics;United States;United States National Institutes of Health;verbal

PROJECT_TITLE: Impact of Music Improvisation Training on Brain Function and Cognition among Older Adults


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Human Genome;Pediatric

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative This research project promises to deliver a number of insights into the evolution of gene expression in the eye and congenital eye disease. By contrasting the genomes of blind and sighted mammal species, it will pinpoint regions of DNA important for vision and which are likely to be involved in human eye diseases. The project will then explicitly test for mutations in these regions in patients with congenital eye disease.

PI_NAMEs: CHIKINA, MARIA D;CLARK, NATHANIEL L (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Acceleration;Address;Affect;Automobile Driving;Binding;Biological Assay;blind;Blindness;Catalogs;causal variant;Characteristics;Child;Chromatin;Clinic;Code;comparative genomics;Computer Models;Computing Methodologies;congenital eye disease;Data;de novo mutation;design;Deterioration;Development;Developmental Gene;Diagnosis;diagnostic panel;Disease;DNA;DNA Sequence;Embryo;Embryonic Development;Enhancers;Evolution;Exclusion;Eye;Eye Abnormalities;Eye Development;Eye diseases;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene regulatory network;gene therapy;Genes;Genetic;genetic regulatory protein;Genome;genome-wide;Genomic approach;Genomic Segment;Goals;High-Throughput Nucleotide Sequencing;Human;improved;in vivo;insight;loss of function;Mammals;Marsupialia;Mission;Modeling;Mole Rats;Mole the mammal;molecular phenotype;Mus;Mutation;Names;National Eye Institute;novel;novel diagnostics;novel therapeutics;Nucleic Acid Regulatory Sequences;Ocular Onchocerciasis;Parents;Patients;Pattern;Phenotype;Process;Proteins;rare variant;Regulator Genes;Regulatory Element;Research Project Grants;Retina;Safety;software development;Sotalia;spatiotemporal;Structure;Surface;Testing;Tissues;tool;trait;transcription factor;Transgenic Organisms;Untranslated RNA;Vision;Zebrafish

PROJECT_TITLE: Discovery and characterization of ocular regulatory elements through evolutionary analysis

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK GENOME CENTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Understanding the effects of genetic variation on gene regulation is a formidable challenge for interpreting genetic associations with complex traits and diseases. Here, we propose to reveal how genomic variation shapes immune cell and autoimmune disease phenotypes, by developing a generalizable toolkit that leverages cutting- edge gene editing and single-cell profiling technologies to produce high-throughput, genome-wide maps of gene regulatory elements and variants. This open and accessible resource of enhancer and variant effects on molecular, cellular, and organismal phenotypes related to immune function will serve as a crucial knowledgebase for understanding the genetics of autoimmune disorders and therapeutic development.

PI_NAMEs: LAPPALAINEN, TUULI ;LITTMAN, DAN ;SANJANA, NEVILLE  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Alleles;Architecture;Autoimmune;Autoimmune Diseases;base editing;Biological;candidate selection;causal variant;cell motility;Cell Physiology;Cell surface;Cell Survival;cell type;Cells;Chromatin;chromatin immunoprecipitation;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR interference;CRISPR screen;Crohn's disease;Data;Data Analyses;Dimensions;Disease;disease phenotype;disorder risk;Elements;Enhancers;Etiology;Expanded CRISPR-compatible cellular indexing of transcriptomes and epitopes by sequencing;functional genomics;gain of function;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic association;Genetic Complementation Test;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome editing;Genome engineering;Genome Mappings;genome wide association study;genome-wide;genome-wide analysis;genomic data;genomic locus;genomic variation;Genomics;Goals;gut homeostasis;gut inflammation;Heritability;high throughput analysis;Homeostasis;Human;human disease;Human Genetics;Immune;immune function;Immune response;Immunology;Immunophenotyping;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;Infusion procedures;insight;Insulin-Dependent Diabetes Mellitus;Intervention;knowledgebase;Large Intestine;Link;loss of function;Maps;Measurable;Measurement;Measures;Methods;migration;Molecular;molecular phenotype;mouse model;multi-scale atlas;multiple omics;Mus;Mutagenesis;new technology;next generation;novel;Nucleotides;Open Reading Frames;Organ;Pathogenicity;Pathway interactions;peripheral blood;Phenotype;Physiological;prevent;Proteome;Psoriasis;Regulation;Regulatory Element;Regulatory Pathway;Repression;Research;Resolution;Resources;Role;Shapes;Site;Small Intestines;Statistical Models;Surface;System;Systemic Lupus Erythematosus;T cell differentiation;T-Lymphocyte;technological innovation;Technology;Testing;therapeutic development;Tissues;trait;transcriptome;transcriptomics;Ulcerative Colitis;Umbilical Cord Blood;Untranslated RNA;Variant

PROJECT_TITLE: Multiscale genome engineering to map cis-regulatory variants in human and mouse


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DAVIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Plants express small RNAs that accumulate to high levels in reproductive organs harboring the male germline; these small RNAs show interesting parallels to the animal piRNAs, and perturbation of their biogenesis or activities causes sterility. Our proposed study aims to understand the localization, biogenesis, functions, and targets of a specialized class of the small RNAs (the 21-nt phased, small interfering RNAs) that are abundant prior to meiosis, using the maize as the model system. The research outcomes will provide mechanistic insights into the biogenesis and functions of these small RNAs, with the potential to illuminate why plants have evolved this unusual small RNA pathway enriched in or even specific to male reproduction.

PI_NAMEs: CZYMMEK, KIRK ;MEYERS, BLAKE C (contact);WALBOT, VIRGINIA E

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Angiosperms;Animals;Biochemical;Biogenesis;Biological Models;Biology;Cell Differentiation process;Cells;chromatin modification;Chromosomes;CRISPR/Cas technology;Data;Defect;Dependence;Development;Developmental Process;Distal;DNA Methylation;DNA Polymerase II;DNA Transposable Elements;Drosophila genus;Drug or chemical Tissue Distribution;Environment;Epidermis;Evolution;Exhibits;experimental study;Failure;Family;Fertility;Genetic;Genome;Genome Stability;genome-wide;Genomics;Germ Lines;Goals;gonad development;Grain;Image;Individual;insight;Maize;male;male fertility;Male Sterility;Mammals;Maps;Mediating;Meiosis;Messenger RNA;MicroRNAs;Minor;Modeling;Molecular;Movement;Mus;mutant;Mutation;Nature;Nematoda;novel;Organ;Oryza sativa;Outcomes Research;Paper;Pathway interactions;Phase;Phenotype;piRNA;Plant Model;Plants;pluripotency;Poaceae;Pollen;Production;Proteins;Reporting;Reproduction;reproductive;Reproductive Biology;reproductive development;reproductive organ;Research;Rice;RNA;RNA Precursors;Role;Signal Transduction;single-cell RNA sequencing;Small Interfering RNA;Small RNA;Somatic Cell;spatiotemporal;sperm cell;stem cells;Sterility;Techniques;Testis;Transcript;transcription factor;Untranslated RNA;Work;Zea mays

PROJECT_TITLE: The biogenesis and functions of pre-meiotic small RNAs in male reproductive development in maize

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Baltimore CASCADE Study Site (BaCSS Project) Project Narrative  African American Women living with HIV in disadvantaged regions of the US have an increased risk of cervical cancer and require focused prevention interventions using novel and emerging technologies. In the BaCSS Project, we engage the population science and clinical trials expertise and resources of the University of Maryland School of Medicine (UMSOM) to establish a clinical study site for the CASCADE network. The project provides operational leadership and pluripotent infrastructure in support of the implementation science studies and pragmatic clinical trials of evidence-based interventions for the prevention and early diagnosis of cervical cancer and supports the development of concepts and protocols to overcome barriers and reduce failures in cervical cancer prevention in WLWH.

PI_NAMEs: ADEBAMOWO, CLEMENT ADEBAYO (contact);TAYLOR, GREGORY H

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Address;African American;African American Women;Age;Age of Onset;Alcohol abuse;Area;Artificial Intelligence;Baltimore;Caring;Cervical;cervical cancer prevention;Cervical Cancer Screening;cervicovaginal;Characteristics;chronic infection;Cities;Clinical;Clinical effectiveness;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Network;clinically significant;Collaborations;Colposcopy;Communicable Diseases;Communities;community advisory board;community engagement;Community Outreach;comorbidity;Comprehensive Cancer Center;computerized;County;Cytopathology;Data;data management;Data Science;Development;Disadvantaged;Disease;Early Diagnosis;economic disparity;effectiveness clinical trial;effectiveness evaluation;Emerging Technologies;Enrollment;ethnic disparity;Ethnic Origin;Evaluation;Evidence based intervention;Excision;Failure;Gender;Gynecologic Oncology;Health;health care availability;health care service;health illiteracy;Health Services Accessibility;Heterogeneity;High Prevalence;high risk;HIV;Home;Housing;Human Papillomavirus;Human Resources;immune reconstitution;implementation science;implementation strategy;improved;Incidence;Informatics;Infrastructure;inner city;insight;Intervention;Laboratories;Leadership;Link;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maryland;medical schools;Mental Health;Methods;molecular diagnostics;mortality;Neighborhoods;new technology;novel;oncology service;Outcome;patient navigation;Patients;peer support;Population;population based;Population Sciences;Poverty;Pragmatic clinical trial;pragmatic implementation;premalignant;Prevalence;Prevention;preventive intervention;programs;protocol development;Protocols documentation;Race;racial disparity;recruit;Recurrent disease;Research;Resources;Risk;Risk Factors;Sampling;screening;screening guidelines;Services;sex;Site;social disparities;social health determinants;Substance abuse problem;Technology;Translational Research;Transportation;Universities;University resources;uptake;Viral Load result;Visualization;Woman;women's prevention


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: ATHENS

ORG_NAME: LECTENZ BIO, INC.

PHR: PROJECT NARRATIVE Therapeutic glycoproteins (biologics) such as antibodies address critical health care needs, but there are currently no simple methods for analyzing the attached glycans (sugar molecules) during the biologics production. The ability to monitor the glycosylation of biologics during their production would be transformative for biopharmaceutical R&D and would accelerate the creation of new biologics and biosimilars. Our innovative technology enables monitoring of protein glycosylation in near real-time in a robust and convenient manner.

PI_NAMEs: YANG, LORETTA  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Acceleration;Address;Adoption;Affect;analytical method;Antibodies;Basic Science;Binding;Biological Models;Biological Products;Biological Response Modifier Therapy;Carbohydrates;Cell Culture Techniques;Chemicals;Chromatography;commercialization;Complement;Consumption;cost;cost effective;Coupled;Data;design;Detection;Development;Equipment;ERBB2 gene;Erythropoietin;Fermentation;Flow Cytometry;Gases;Glycoproteins;glycosylation;Half-Life;Healthcare;Homologous Gene;immunogenicity;Industrialization;innovative technologies;instrument;Mammalian Cell;Mass Spectrum Analysis;Measurement;Methodology;Methods;Microspheres;Modeling;Monitor;novel;novel strategies;Optics;Pattern;Performance;pharmacologic;Pharmacologic Substance;Phase;Polysaccharides;portability;Process;Production;Property;Protein Glycosylation;protein purification;Proteins;Protocols documentation;Publishing;Quality Control;Reagent;Recombinants;Reporting;Research;research and development;Safety;Sampling;screening;Serum;Specificity;sugar;Suspensions;Technology;Temperature;Therapeutic;therapeutic development;Time;tool;Trastuzumab;United States Food and Drug Administration;Universities;Variant;Work

PROJECT_TITLE: A new approach to monitoring glycosylation during glycoprotein production


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative This project aims to build the first computerized adaptive test based on multidimensional item response theory to more precisely, rapidly, and repeatedly assesses cognitive abilities, compared to existing gold-standard in- person neuropsychological testing. This assessment will be suitable across the adult lifespan (from cognitively normal younger adults to older adults with MCI), thereby advancing early detection of cognitive decline associated with Alzheimer’s disease. It also would be available online, thereby increasing accessibility in underserved populations and providing a new tool for basic and applied research.

PI_NAMEs: GIBBONS, ROBERT D (contact)

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: Administrator;Adopted;Adult;Age;age related changes;Age Years;aged;Aging;Alzheimer's Disease;American;Applied Research;Assessment tool;attentional control;Basic Science;Calibration;Clinic;Clinical;Cognition;Cognitive;cognitive ability;cognitive function;cognitive performance;cognitive task;cognitive testing;computerized;Computers;Consumption;Data;design;Development;Dimensions;Discrimination;Early Diagnosis;Early Intervention;Episodic memory;Evaluation;flexibility;Funding;Health;Healthcare;human old age (65+);Human Resources;Immune;Impaired cognition;Impairment;improved;Individual;innovation;Internet;Language;Learning;Life Cycle Stages;life span;Link;Longitudinal Studies;Masks;Measurement;Measures;Mental Health;Mental Tests;mild cognitive impairment;Modeling;National Institute of Mental Health;Neuropsychological Tests;Neuropsychology;Office Visits;older adult;Outcome;Participant;Persons;platform-independent;Population;Preparation;processing speed;Protocols documentation;prototype;Recommendation;Research;Research Personnel;Resources;Respondent;response;Risk;risk stratification;Sampling;self-directed learning;Semantic memory;Short-Term Memory;Standardization;Stimulus;Structure;Subgroup;Testing;theories;Time;tool;Training;Underserved Population;Validation;young adult

PROJECT_TITLE: Adaptive Testing of Cognitive Function based on multi-dimensionalItem Response Theory

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Machine Learning and Artificial Intelligence;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Alcohol-associated liver disease (ALD) is the most common cause of death from liver disease and accounts for over 20,000 deaths annually, and while ALD morbidity and mortality differs among racial/ethnic minorities, we do not have an adequate understanding of why these disparities exist. We will apply a conceptual framework to identify specific clinicodemographic (e.g., alcohol use patterns), biologic (e.g., genetics), and social determinants of health (e.g., barriers to care) factors that influence racial/ethnic disparities in ALD outcomes. This proposal will yield critical data to inform future interventions to reduce disparities and improve outcomes for patients with ALD.

PI_NAMEs: COTTER, THOMAS GERARD (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Accounting;Address;Affect;Age;alcohol abstinence;Alcohol consumption;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;American Indians;AODR mortality;Award;barrier to care;Bilirubin;Biological;Black Populations;Black race;burden of illness;career;Case/Control Studies;Cause of Death;Cessation of life;Cirrhosis;Clinical;Clinical Research;cohort;cultural values;Data;Development;disease natural history;Disease Outcome;disease prognosis;Disease Progression;Disparity;disparity reduction;Electronic Health Record;ethnic difference;ethnic disparity;ethnic diversity;ethnic health disparity;ethnic minority;Ethnic Origin;Ethnic Population;Europe;European;experience;Fibrosis;Funding;Future;Genes;Genetic;Genetic Diseases;genetic epidemiology;Genetic Risk;Goals;Health;health disparity;Health Services;Hispanic;Hispanic Populations;improved;improved outcome;interest;International;Intervention;Knowledge;Liver diseases;liver transplantation;Logistic Regressions;Machine Learning;machine learning method;Mediation;Mediator;Mentors;Mentorship;Metabolic syndrome;Modeling;Monitor;Morbidity - disease rate;mortality;Natural History;Not Hispanic or Latino;Organ;Outcome;Patient Care;patient prognosis;Patient-Focused Outcomes;Patients;Pattern;Population;Population Heterogeneity;Prevalence;Prognosis;prognostic;Prognostic Factor;prospective;Prospective cohort;protective factors;Psychological Impact;Psychosocial Factor;Public Health;Race;racial difference;racial disparity;racial diversity;racial health disparity;racial minority;racial population;Regression Analysis;Research;Research Personnel;research study;Risk;Risk Factors;risk prediction;risk stratification;Role;Sampling;Severity of illness;sex;Single Nucleotide Polymorphism;skills;social health determinants;Social Values;Socioeconomic Status;socioeconomics;statistics;Steatohepatitis;Survey Methodology;Surveys;Talents;therapy development;Time;Training

PROJECT_TITLE: Determining the Influence of Clinicodemographic, Biologic and SDOH Factors in Racial and Ethnic Disparities in the Prognosis of Alcohol-Associated Liver Disease

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Project Narrative The proposed project will inform public health research and practice on developing prevention and intervention programs that will mitigate the effect of adversity on adolescent drug use vulnerability and later drug use and abuse. In addition, our study will help determine the utility of neuromarkers to advance addiction prevention models via earlier and more accurate risk assessments.

PI_NAMEs: OSHRI, ASSAF  (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;adolescent drug use;Affect;Age;Attenuated;Behavior;Behavioral;Biological Markers;Biological Models;Brain;Breeding;Clinical;Cognitive;cognitive control;cognitive development;cognitive neuroscience;Collaborations;Communication;Communities;contextual factors;cultural values;Data;Data Set;Decision Making;Development;Dimensions;Discrimination;Drug abuse;Drug Addiction;drug development;drug misuse;Drug Modelings;Drug usage;drug use behavior;drug use vulnerability;early life adversity;Ecology;Ecosystem;Emotional;Emotions;ethnic identity;Ethnic Origin;Ethnic Population;Etiology;Exhibits;Exposure to;Family;Family dynamics;family influence;Growth;Heterogeneity;Human Biology;improved;Impulsivity;Individual Differences;Informal Social Control;innovation;Intervention;intervention program;Investigation;knowledge base;Link;longitudinal dataset;Measurement;Measures;Mediating;Mediator;Minority;minority children;Modeling;multilevel analysis;neural;neurobehavioral;Neurobiology;Neurocognitive;neurodevelopment;neuroimaging;Neurosciences;Pathway interactions;Pattern;peer;Persons;Pharmaceutical Preparations;Prevention;Prevention program;preventive intervention;Process;protective factors;Psychometrics;psychosocial;public health research;Race;racial population;Recording of previous events;Regulation;Research;resilience;response;Rest;Rewards;Risk;Risk Assessment;Risk Behaviors;Risk Factors;Risk Taking;Role;Schools;Science;Shapes;Short-Term Memory;social;social culture;Social Environment;Specificity;Statistical Models;Stress;stressor;Subgroup;System;Systems Theory;Techniques;Testing;theories;Time;Youth

PROJECT_TITLE: A Neuroecological Approach to Examining the Effects of Early Life Adversity on Adolescent Drug Use Vulnerabilities Using the ABCD Dataset


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurosciences;Pain Research;Physical Rehabilitation;Primary Health Care;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Despite increased availability of resources for chronic pain, veterans living in rural areas have poor access to these services and must attempt to navigate multiple health systems to receive comprehensive treatment, often resulting in poor clinical outcomes. In this multisite study, we will test the effectiveness of a tele- collaborative care intervention for chronic pain among rural veterans, which is designed to enhance care coordination across settings and lead to clinically significant improvements in pain, function, and quality of life. The trial will include an implementation evaluation and, if the results are significant, will lead to improved care across the VA nationally.

PI_NAMEs: LOVEJOY, TRAVIS IAN (contact);MORASCO, BENJAMIN J.

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: Activities of Daily Living;Address;Adult;Affect;biopsychosocial;Birth;care coordination;Care given by nurses;care systems;Caring;Case Manager;Chronic;chronic pain;chronic pain management;chronic pain patient;Clinical;clinical research site;Clinical Trials;clinically significant;Cold Therapy;Collaborations;collaborative care;collaboratory;Communication;Communities;Community Health Services;Community Health Systems;Community Healthcare;compare effectiveness;Complementary Health;Consultations;Cost Effectiveness Analysis;Data;Data Collection;design;Development;Education;effective intervention;Effectiveness of Interventions;effectiveness testing;Eligibility Determination;Ethnic Origin;evidence base;Exercise Therapy;experience;Feeling suicidal;Female;follow-up;Foundations;Future;future implementation;General Population;Geography;Goals;Health care facility;Health Insurance;Health Services Accessibility;Health system;Heterogeneity;implementation evaluation;implementation intervention;implementation process;improved;improvement on sleep;incremental cost-effectiveness;Integrative Medicine;Intensive Care;Intervention;Letters;male;Medicaid;medical specialties;Medicare;Mental Health;Methods;Mindfulness Training;Modality;Modeling;Not Hispanic or Latino;operation;Opioid;Outcome;outreach;Pain;Pain Clinics;Pain intensity;Pain interference;Pain management;Pain Measurement;pain model;pain self-management;Participant;Patient Education;patient navigation;Patients;payment;Persistent pain;pharmacologic;Phase;Physical Function;Physical therapy;Physicians;pilot test;Population;pragmatic trial;prescription monitoring program;primary outcome;Privatization;Procedures;process evaluation;programs;Protocols documentation;Provider;Quality of life;Race;racial minority;Randomized;randomized, clinical trials;recruit;Relaxation Therapy;Reporting;Research;Resources;Rural;rural area;Rural Health;rural patients;Safety;Sampling;secondary outcome;Self Management;Severities;sex;Site;Sleep;Social support;substance use;suicidal behavior;Symptoms;System;telehealth;Term Birth;Testing;Therapeutic heat application;treatment as usual;treatment effect;treatment services;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Woman;Work

PROJECT_TITLE: Tele-Collaborative Outreach to Rural Patients with Chronic Pain: The CORPs Trial


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Recent studies have found that expression of the androgen receptor splice variant 7 in circulating tumor cells can identify resistance to hormone therapies in approximately 10% men with prostate cancer. We have developed a new test that builds upon this assay to identify other patients at risk for resistance to these therapies. This proposal validates this new assay to move us closer to the goal of achieving better precision in treating patients.

PI_NAMEs: ARMSTRONG, ANDREW J;HALABI, SUSAN ;LANG, JOSHUA MICHAEL (contact);RATHKOPF, DANA

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: abiraterone;Acceleration;Acetates;Address;Adenocarcinoma;advanced prostate cancer;Aftercare;androgen independent prostate cancer;Androgen Receptor;Appearance;AR gene;Area;Biological;Biological Assay;Biological Markers;Biomedical Engineering;Biopsy;Blood;Blood Cells;bone;cancer biomarkers;cancer cell;Cancer Center;Cancer Patient;Categories;Cells;Cellular Assay;Centrifugation;chemotherapy;Circulation;CLIA certified;Clinical;Clinical Research;Clinical Trials;clinically relevant;Clonal Expansion;cohort;Collaborations;Data Analyses;Detection;detection method;Development;Diagnostic;diagnostic accuracy;diagnostic tool;Disease;Disease Resistance;DNA;drug development;Early Diagnosis;Early identification;Enhancers;Ensure;enzalutamide;Evaluation;Evolution;Exclusion;Exposure to;Failure;Foundations;Frequencies;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic Transcription;Goals;Histologic;hormone therapy;Hygiene;improved;inhibitor;Institution;Laboratories;Left;Ligand Binding Domain;liquid biopsy;Liquid substance;Liver;lymph nodes;Magnetism;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Memorial Sloan-Kettering Cancer Center;men;Messenger RNA;Metastatic Prostate Cancer;Methods;Molecular;Mutation;Neoplasm Circulating Cells;Neuroendocrine Prostate Cancer;Neuroendocrine Tumors;novel diagnostics;novel therapeutics;optimal treatments;Output;particle;patient biomarkers;Patient Care;patient subsets;Patients;Performance;Population;precision medicine;predictive marker;Preparation;Probability;Process;Prognosis;prognostic;prognostic of survival;prognostic value;Progression-Free Survivals;prospective;Prospective Studies;Protein Analysis;Provenge;radiological imaging;Radium;randomized, clinical trials;Reagent;Receptor Signaling;Recommendation;research clinical testing;Research Personnel;Resistance;Resistance development;resistance mechanism;response;Risk;RNA;RNA Splicing;Sampling;Site;Specificity;success;Surface Properties;Surface Tension;System;Systematic Bias;targeted treatment;taxane;Technology;Testing;Therapeutic;therapy resistant;Time;Tissues;tool;treatment strategy;treatment stratification;Tube;tumor;Universities;Validation;Variant;virtual;Wisconsin

PROJECT_TITLE: Validation of predictive liquid biomarkers for patients with metastatic prostate cancer


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Behavioral interventions are considered a critical category for slowing, or even preventing, cognitive decline and progression of mild cognitive impairment. This study will refine a cognitive training program incorporating the approach of precision medicine, and pilot test the refined training program’s cognitive and neural effects in older adults with mild cognitive impairment. If this program is found to be effective, such a program could be investigated further to assess its promise for preventing or delaying the onset of dementia.

PI_NAMEs: LIN, FENG VANKEE (contact);TAPPARELLO, CRISTIANO ;ZHANG, ZHENGWU

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: Address;Aging;Alzheimer's disease pathology;attentional control;Autonomic nervous system;Behavior Therapy;Blood;Brain;brain based;Cardiac;Cardiovascular system;Categories;Clinical Trials;Cognitive;cognitive change;cognitive enhancement;cognitive function;cognitive reserve;cognitive task;cognitive training;comparison control;computerized;Data;Data Analyses;Dementia;design;Development;Dissociation;Double-Blind Method;Educational Intervention;efficacy trial;feasibility testing;flexibility;follow-up;Frequencies;Functional Magnetic Resonance Imaging;Future;Health;heart rate variability;Impaired cognition;improved;indexing;Individual;information processing;Intervention;intervention refinement;Interview;Learning;Link;Measures;Methods;mild cognitive impairment;Monitor;Nerve Degeneration;neural;neural circuit;Neuronal Plasticity;older adult;Performance;personalized approach;Phase;pilot test;pilot trial;Population;precision medicine;prevent;processing speed;programs;prototype;Questionnaires;Randomized;Randomized, Controlled Trials;response;Series;Signal Transduction;Task Performances;Testing;theories;Time;Training;Training Programs;usability;Work

PROJECT_TITLE: Develop an ANS-based Personalized Cognitive Training for Mild Cognitive Impairment


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric

ORG_CITY: PISCATAWAY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The underlying cognitive mechanisms involved in proportional reasoning have received little investigation and are poorly understood. The current proposal aims to address this issue by using developmental and computational modeling approaches to characterize behavioral signatures of cognitive representations, cognitive processes, and symbolic strategies used to engage in proportional reasoning from infancy to adulthood. The long-term goal of this work is to develop a coherent theory of how people reason about proportion and to leverage this knowledge to support young children’s proportional reasoning and adults’ probabilistic decision making.

PI_NAMEs: HURST, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TITLE: Cognitive Processes Underlying Ratio Representation Across Development


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: NARRATIVE Tumors are not simply collections of mutated cells that grow in isolation; rather, they respond to and modify both the physical microenvironment and a variety of host cells in the organ they are invading. These changes in ecology (“∆-Ecology”) are key to understanding tumor progression and the response to therapy – particularly the development of resistance. We focus on NSCLC, the most common and among the most lethal of human cancers and will define the ecological and evolutionary dynamics that govern disease progression and treatment, with the goal of driving novel therapeutic strategies that exploit this ∆-Ecology.

PI_NAMEs: ANDERSON, ALEXANDER ROBERTSON ALLAN (contact);GATENBY, ROBERT A

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Aftercare;Anatomy;Automobile Driving;Biological Models;Calibration;cancer cell;cancer therapy;cell transformation;cell type;Cells;Clinical;Clinical Data;clinical decision-making;Collaborations;Collection;Complex;Computing Methodologies;cytokine;cytotoxic;Data;data repository;Development;Disease;Disease Progression;driver mutation;Ecological Change;Ecology;Ecosystem;Encapsulated;Engineering;Environment;Epidermal Growth Factor Receptor;Evolution;Extinction;Failure;Fibroblasts;fitness;Genes;Goals;Grant;Growth;Heart;Homeostasis;host neoplasm interaction;Human;Immune;Immune response;Immunity;Immunologics;Immunologist;Immunotherapy;in silico;In Vitro;in vivo;Individual;Infiltration;inhibitor therapy;Invaded;Knowledge;KRAS2 gene;Lung;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;mathematical analysis;mathematical methods;mathematical model;Mathematics;Microanatomy;Modeling;Molecular;multidisciplinary;Mutate;Mutation;Neoplasms;neoplastic;neoplastic cell;Non-Small-Cell Lung Carcinoma;Normal Cell;novel therapeutic intervention;Nutrient;Oncologist;Oncology;Organ;Outcome;outcome prediction;Oxygen;Pathologist;Patients;Philosophy;Population;predictive modeling;pressure;Process;Production;Proliferating;Property;Relapse;Resistance;Resistance development;Resource Sharing;Resources;response;Sampling;Shapes;success;targeted agent;targeted treatment;Testing;Therapeutic;Therapy Clinical Trials;Thoracic Oncology;Time;Tissues;tool;Treatment Protocols;treatment response;treatment strategy;tumor;tumor behavior;tumor growth;tumor progression;Work

PROJECT_TITLE: The Delta Ecology of NSCLC Treatment


NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer

PI_NAMEs: ANDERSON, ALEXANDER ROBERTSON ALLAN (contact)

PROJECT_TERMS: Adherence;Award;Budgets;Cancer Center;Collaborations;Communication;dashboard;Development;Ecology;Education;Education and Outreach;Educational workshop;Ensure;equity, diversity, and inclusion;Evaluation;Fostering;Funding;Funding Opportunities;high school;Information Distribution;innovation;Institution;interest;Internships;Investigation;Letters;Malignant Neoplasms;meetings;member;Mission;Non-Small-Cell Lung Carcinoma;Organization and Administration;outreach;Pilot Projects;Play;Preparation;Process;programs;Progress Reports;Reporting;Research;Research Personnel;Resources;Role;social media;symposium;Systems Biology;Travel;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Lung;Lung Cancer;Machine Learning and Artificial Intelligence

PROJECT_TERMS: Affect;analysis pipeline;anti-PD-1;Antitumor Response;arm;Autopsy;Biological Markers;Biopsy;Blood;Calibration;cancer cell;Cancer Patient;cancer therapy;Cells;Clinical;Clinical Data;clinical efficacy;Clinical Research;Clinical Trials;Colon Carcinoma;Combined Modality Therapy;computer infrastructure;CT26;Data;deep learning;design;Development;Disease;Ecological Change;Ecology;Evolution;experimental study;Future;Goals;Human;Immune;Immune checkpoint inhibitor;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;in vivo;inhibitor;inhibitor therapy;KRAS2 gene;Lung Neoplasms;Machine Learning;Malignant Neoplasms;mathematical model;MEKs;Modeling;multiplexed imaging;Mus;mutant;Nature;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;Pathway interactions;patient response;Patients;pembrolizumab;Pharmaceutical Preparations;phase I trial;Phase I/II Trial;pre-clinical;predicting response;predictive modeling;prevent;programs;Randomized;RAS inhibition;Resistance;Resistance development;resistance mechanism;response;Sampling;Signal Pathway;spatiotemporal;Specimen;Stains;statistics;Study models;synergism;System;T cell response;T cell therapy;targeted agent;targeted treatment;Testing;Thoracic Oncology;Tissue Donations;tool;Treatment Protocols;treatment response;treatment strategy;tumor;tumor progression;Tumor-Infiltrating Lymphocytes;whole slide imaging;Work

PROJECT_TITLE: Project 1: Delta immune Ecology of NSCLC


PI_NAMEs: MARUSYK, ANDRIY  (contact)

PROJECT_TERMS: Allografting;analysis pipeline;Birth;Calibration;cancer therapy;Cell Proliferation;Cells;Cessation of life;Combined Modality Therapy;CRISPR library;Data Analyses;Development;digital pathology;Disease remission;DNA Sequence Alteration;Ecology;Ecosystem;Epidermal Growth Factor Receptor;Epigenetic Process;Evolution;Experimental Models;experimental study;Failure;functional genomics;Genetic Programming;Guide RNA;in silico;in vivo;inhibitor;insight;Interdisciplinary Study;knowledge base;KRAS2 gene;Lentivirus Vector;model development;Modeling;Molecular;mouse model;Mus;mutant;Mutation;neoplastic;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;novel strategies;Oncogenic;Outcome;paracrine;Patients;pharmacologic;Phenotype;Population;Probability;Proliferating;Property;Receptor Protein-Tyrosine Kinases;Relapse;Residual Neoplasm;Residual state;Resistance;resistance mechanism;resistance mutation;response;Shapes;Signal Transduction;spatiotemporal;Speed;System;targeted treatment;Therapeutic;Therapeutic Intervention;Time;tool;transcriptomics;translational approach;treatment optimization;tumor;tumor growth;Vertebral column;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Project 2: Delta Stromal Ecology of NSCLC


ED_INST_TYPE: SCH OF BUSINESS/PUBLIC ADMIN

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative This project aims to identify genetic variants that causally influence a range of health, disease, aging, and behavioral phenotypes in diverse populations. Existing evidence from genetic association studies are confounded by environmental factors that may be correlated with genetic variants. Using new data from family- based studies and new statistical tools we are developing, we will be able to identify causal influences, study more diverse populations, and in some cases, increase statistical power.

PI_NAMEs: YOUNG, ALEXANDER THOMAS IAN STRUDWICK (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Aging;Agreement;Algorithms;Alzheimer's Disease;behavioral phenotyping;biobank;causal variant;Child;China;cohort;Collaborations;Computer software;Data;Disease;Drops;Environment;Environmental Risk Factor;European;European ancestry;Family;Genes;Genetic;genetic architecture;genetic association;genetic pedigree;genetic variant;genome wide association study;Genotype;Haplotypes;Health;Heritability;improved;indexing;Individual;Late Onset Alzheimer Disease;Late-Onset Disorder;Longevity;Meiosis;Mendelian randomization;Meta-Analysis;Methodology;Methods;Modeling;Natural experiment;Natural Selections;Nature;offspring;Parents;Participant;Partner in relationship;Phenotype;Population;Population Heterogeneity;population stratification;Proxy;Publishing;Randomized;Recording of previous events;repository;Research;Research Proposals;Role;Sample Size;Sampling;Siblings;statistics;Sum;Testing;theories;tool;trait

PROJECT_TITLE: Mendelian imputation for family-based GWAS and association-by-proxy in diverse ancestries

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer;Pediatric

PI_NAMEs: BRADY, RENEE  (contact)

PROJECT_TERMS: Acceleration;Advocate;anti-cancer research;Applications Grants;Archives;Area;Award;Biological;Biological Models;Biological Sciences;Cancer Center;Cancer Patient;career;Clinic;Clinical;Clinical Data;Clinical Oncology;Collaborations;college;Communities;Complex;Data;data sharing;Dedications;design;Development;Dryness;Ecology;Education;Education and Outreach;Educational process of instructing;Educational workshop;Elements;experience;Experimental Models;experimental study;Faculty;Festival;Fostering;Funding;Future;Gene Expression;General Population;Generations;Goals;graduate student;high school program;High School Student;histological stains;Home;Image;Incubators;Individual;innovation;Institution;interdisciplinary collaboration;interest;Internships;Joints;Journals;learning materials;lectures;Life;Literature;Malignant Neoplasms;Manuscripts;mathematical model;Mathematics;member;Minority;minority investigator;minority patient;Modality;Modeling;Molecular;next generation;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;Oncologist;Oncology;Organ;outreach;Paper;Participant;Patients;Pilot Projects;Postdoctoral Fellow;predicting response;Preparation;Process;programs;Publications;Recruitment Activity;Research;Research Design;Research Personnel;Science;Scientist;Senior Scientist;Series;Students;symposium;System;Systems Biology;Taste Perception;Techniques;Tissues;tool;Training;Training Activity;training opportunity;Translating;Translations;treatment strategy;tumor initiation;undergraduate student;university student;Update;web site;working group

PROJECT_TITLE: Outreach Core


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Polygenic risk scores (PRSs) are set to play a key role in advancing our understanding of the etiology and treatment of disease, but they presently underperform in non-European populations due to limited availability of diverse population datasets and limited PRS methods designed for application to global populations. To overcome this “PRS portability problem”, we develop a suite of PRS computational tools that incorporate sophisticated, high-resolution statistical modeling of structure in terms of: (i) ancestry, (ii) genetic risk, (iii) the genome, and (iv) phenotype. Our modeling will provide a step-change in the accuracy of PRSs computed in diverse populations and allow users to detect G*E interactions, the functional sources of the portability problem, and the determinants of disease heterogeneity among ancestries.

PI_NAMEs: O'REILLY, PAUL FRANCIS (contact)

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: 3-Dimensional;Accounting;Address;Admixture;African;African American;American;Basic Science;Bayesian Modeling;Biomedical Research;Clinic;Clinical;Collection;Complex;Computer software;computerized tools;Data;Data Set;design;Development;Disease;disease heterogeneity;disorder risk;disparity reduction;Environment;Etiology;European;European ancestry;Failure;flexibility;Formulation;Future;gene environment interaction;Gene Frequency;Genes;Genetic;Genetic Models;genetic predictors;Genetic Risk;Genome;genome wide association study;genome-wide;Goals;Heterogeneity;Human;improved;Individual;innovation;insight;method development;Methods;Modeling;next generation;novel;Pathway interactions;Phenotype;Play;polygenic risk score;Population;Population Genetics;Population Heterogeneity;portability;precision medicine;Production;Proxy;Randomized;rapid growth;Recording of previous events;Reporting;Research;Research Personnel;Resolution;Risk;risk variant;Role;Sampling;Scoring Method;Software Tools;Source;Statistical Models;Structure;Target Populations;Testing;Time;tool;trait

PROJECT_TITLE: BridgePRS: bridging the gap in polygenic risk scores between ancestries.


NIH_SPENDING_CATS: Bioengineering;Cancer;Lung;Lung Cancer

PROJECT_TERMS: Animals;Basic Science;Blood;Blood Vessels;Body System;Bone Tissue;brain tissue;Breast;Calibration;cancer cell;Cancer Center;cancer therapy;cancer type;cell type;Clinical;Clinical Data;clinical investigation;Clinical Trials;cohort;Complex;Computer Models;Connective Tissue;Data;Data Collection;data integration;Development;Differential Equation;Disease;dynamic system;Ecology;Evolution;Faculty;flexibility;Goals;Heterogeneity;Histology;Human;Hybrids;Immune;In Vitro;in vivo;innovation;insight;Link;Logic;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Maps;mathematical model;Mathematics;member;Metabolism;Methods;Modeling;molecular dynamics;molecular scale;multidisciplinary;Mus;Non-Small-Cell Lung Carcinoma;novel;Oncology;Pathway interactions;Patients;phase I trial;Phenotype;Play;pre-clinical;Preclinical Testing;Process;programs;Prostate;Regimen;Resolution;Sarcoma;Science;Services;Skin;Stromal Neoplasm;Testing;theories;Tissues;tool;treatment optimization;treatment response;treatment strategy;tumor;Tumor Burden;tumor growth;tumor initiation;tumor microenvironment;Uncertainty;virtual;virtual patient;Work

PROJECT_TITLE: Core 1: Mathematical Core


PI_NAMEs: BROWN, JOEL  (contact)

PROJECT_TERMS: 3-Dimensional;Behavior;Biological Markers;Calibration;cancer therapy;Cataloging;Cells;Clinical;Complex;computational pipelines;Computer software;Data;data pipeline;Development;Dimensions;Ecological Change;Ecology;Ecosystem;Environment;Feedback;Generations;Genotype;Heterogeneity;high dimensionality;histological specimens;Histology;Image;image registration;imaging modality;Immune;Immunofluorescence Immunologic;improved;insight;interest;Investigation;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;mathematical model;Methods;Modeling;multimodality;multiplexed imaging;Non-Small-Cell Lung Carcinoma;novel therapeutic intervention;Pattern;Recording of previous events;Resolution;Sampling;Shelter facility;Slice;spatiotemporal;Speed;Stains;Techniques;Testing;Thinking;three dimensional structure;Time;tissue reconstruction;Tissues;tool;treatment response;tumor;tumor behavior;tumor heterogeneity;tumor microenvironment;tumor progression;tumor-immune system interactions;Visualization;whole slide imaging

PROJECT_TITLE: Core 2: Ecological Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health;Women's Health Research

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Pregnancy is a key period to optimize maternal and offspring cardiovascular health. In this project, we will collaborate with the NHLBI and the ENRICH Network to test whether a multi-component intervention delivered in the context of home visiting will improve maternal and child cardiovascular health. This project may have great benefit to society, as interventions delivered in the perinatal period have the potential to influence lifelong cardiovascular health across generations.

PI_NAMEs: DAVIS, MATTHEW M;KHAN, SADIYA SANA;TANDON, SHIV DARIUS (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: 3 year old;5 year old;Address;Adoption;Age;American Heart Association;Behavior Therapy;Birth;Body mass index;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cause of Death;Child;Childhood;clinical center;clinical research site;Clinical Trials Design;clinically relevant;cluster randomized design;Cognitive Therapy;Collaborations;Communities;cost;Data;Development;disability;Disparity;early childhood;Early Intervention;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation hybrid;Eligibility Determination;Enrollment;Ensure;Equity;Ethnic Origin;evidence base;Evidence based intervention;experience;Family;Generations;Geography;Goals;Health;health assessment;Health behavior;health disparity;health of the mother;Health Policy;Health Promotion;healthy weight;High Prevalence;Home;Home visitation;Illinois;Impaired cognition;implementation evaluation;implementation outcomes;Implementation readiness;implementation science;improved;in utero;Indiana;Individual;innovation;intergenerational;International;Intervention;intervention participants;Intervention Studies;Life Cycle Stages;lifestyle intervention;Link;Maintenance;Maternal and Child Health;maternal morbidity;Maternal Mortality;Measures;Mental Depression;Mental Health;Mission;Modeling;Monitor;Mothers;multi-component intervention;multidisciplinary;multiple chronic conditions;National Heart, Lung, and Blood Institute;Network-based;Obesity;offspring;Outcome;Overweight;Parents;Participant;patient navigation;peer support;Perinatal;perinatal period;peripartum depression;Phase;pilot test;Population;Population Heterogeneity;Populations at Risk;Positioning Attribute;Postpartum Period;Pregnancy;pregnant;prenatal;programs;Protocols documentation;Psychosocial Factor;psychosocial outcome;Qualifying;Race;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research Design;Research Personnel;Resources;response;Risk;Science;Services;sex;skills;Societies;Socioeconomic Status;stress management;success;teacher;Techniques;Testing;Time;timeline;transmission process;United States;United States Preventative Services Task Force;virtual delivery;virtual platform;Weight;Work;young adult

PROJECT_TITLE: 2-Generation Interventions to Improve Cardiovascular Health in Indiana and Illinois Through Home Visiting (2-NOURISH)


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

PHR: Project Narrative This community-partnered intervention application will test the implementation and effectiveness of integrating a cardiovascular health (CVH) improvement program into an evidence-based home visiting model, the Family Check-Up (FCU), creating FCU-Heart. Set in the Pittsburgh metropolitan area, this two-phased study will pilot the FCU-Heart intervention and then conduct a multisite randomized clinical trial to assess the impact of FCU-Heart on CVH outcomes of low- income, high-risk postpartum mothers and children up to age 3. FCU-Heart aims to improve CVH and reduce racial disparities in CVH outcomes by assessing maternal CVH, providing direct feedback about each mother’s CVH, then offering skills and resources to promote their own and their infants’ CVH through culturally adapted evidence-based modules with trained FCU-Heart family coaches.

PI_NAMEs: CATOV, JANET M (contact);SHAW, DANIEL S

PROJECT_TERMS: 3 year old;Address;Adherence;Adolescent;Age;antisocial behavior;Area;behavioral health;Biological;Black race;black women;Blood Pressure;blood pressure control;Body mass index;Breast Feeding;Cardiac health;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;checkup examination;Child;Child Behavior;Child Health;Child health care;Child Rearing;Cholesterol;Cities;Color;Communities;community engaged intervention;community partners;Coupled;Credentialing;critical period;cultural competence;Data;Death Rate;Development;Diabetes Mellitus;Diet;diet and exercise;digital solutions;Disparity;early childhood;Education;Effectiveness;effectiveness testing;effectiveness/implementation design;effectiveness/implementation hybrid;empowerment;evidence base;Family;feasibility testing;Feedback;flexibility;follow-up;Gestational Diabetes;Glucose;Goals;Growth;Health;Health behavior;Health Benefit;health care availability;health determinants;health disparity;Health education;health of the mother;Health Promotion;Healthcare;Heart;high risk;Home Blood Pressure Monitoring;Home visitation;Hybrids;Hypertension;implementation context;improved;individualized medicine;Inequity;Infant;information gathering;innovation;Intervention;Life Style;Low income;lower income families;Maintenance;Managed Care;maternal depression;maternal morbidity;Maternal Mortality;maternal outcome;Mental Depression;Mental Health;metropolitan;Modeling;mortality;Mothers;multi-site trial;National Heart, Lung, and Blood Institute;Neighborhoods;novel;nutrition;Obesity;Outcome;Outcome Assessment;Parents;Personal Satisfaction;Phase;Physical activity;Pilot Projects;pilot trial;Postpartum Period;Pregnancy;pregnancy disorder;pregnancy hypertension;premature;prenatal;preservation;programs;Provider;racial disparity;racial health disparity;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;remote intervention;Research;Resources;Risk;School-Age Population;Self Care;severe maternal morbidity;Site;skills;Sleep;Smoking;smoking cessation;social;social health determinants;Social support;Special Supplemental Nutrition Program for Women, Infants, and Children;stress management;substance use;suicidal risk;Testing;Training;treatment effect;treatment program;treatment response;trend;Trust;Weight;Weight Gain;Work;Youth

PROJECT_TITLE: Expanding the Family Check-Up in Early Childhood to Promote Cardiovascular Health of Mothers and Young Children (ENRICH)


ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Continuing funds are requested by 18 vision scientists (holding 20 core eligible NEI R01 grants) to support three resource cores in the merged Department of Ophthalmology, Visual and Anatomical Sciences (official partnering of Ophthalmology and Anatomy/Cell Biology Departments). The cores requested will be central facilities that offer state of the art equipment and experienced research assistants with a common purpose to enable and enhance R01 funded vision research at Wayne State University, and the nearby institution, Oakland University (15 minutes away).

PI_NAMEs: HAZLETT, LINDA D (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Address;adeno-associated viral vector;Adherence;Anatomical Sciences;Anatomy;Award;Bacteria;Basic Science;Biological Assay;Blood Cells;Cell membrane;Cell Separation;Cell Survival;Cellular biology;cellular imaging;Center Core Grants;chemokine;Clinical;Clinical Research;Clinical Sciences;Cloning;Collaborations;Complementary DNA;Confocal Microscopy;Consultations;Core Grant;cost effective;CRISPR/Cas technology;Cryopreservation;Cryopreserved Cell;cytokine;Data;data management;Data Storage and Retrieval;design;digital imaging;DNA;Eligibility Determination;Environment;Enzyme-Linked Immunosorbent Assay;Equipment;Equity;established cell line;Evaluation;experience;Eye;Eye diseases;Faculty;Flow Cytometry;Fostering;Funding;Gene Silencing;Genotype;Gentian Violet;Goals;Grant;Growth;Histopathology;Human Resources;Image;Image Analysis;Immunofluorescence Immunologic;Immunologics;Immunology;Immunology procedure;Immunophenotyping;Individual;innovation;Institution;instrument;Joints;Lasers;light microscopy;member;Membrane Potentials;Microbial Biofilms;Microscope;Molecular;Molecular Biology;Multi-Drug Resistance;Mus;Nature;Nested PCR;Ophthalmology;Phagocytosis;posters;Preparation;Primary Cell Cultures;Production;Productivity;programs;Publications;recruit;Research;Research Assistant;Research Personnel;Research Project Grants;Research Training;Resources;Reverse Transcriptase Polymerase Chain Reaction;Scanning;Scientist;Site-Directed Mutagenesis;slit lamp imaging;small hairpin RNA;Small Interfering RNA;Stains;success;Techniques;Time;tissue culture;Tissue Stains;Tissues;tool;Training;Transfection;translational study;Universities;vector;Vision;Vision research;vision science;Western Blotting;Work

PROJECT_TITLE: Core Grant for Vision Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (07)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

PROJECT_TERMS: Accounting;Advisory Committees;Anatomical Sciences;Anatomy;Budgets;Businesses;Cellular biology;Core Grant;Department chair;design;Eligibility Determination;Equilibrium;Evaluation;experience;Funding;Grant;Human Resources;Institution;medical schools;Ophthalmology;organizational structure;Positioning Attribute;Quality Control;Research;Research Personnel;Resource Allocation;Resources;Schedule;Scientist;Services;skills;Vision;Vision research;vision science


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

PROJECT_TERMS: Anatomical Sciences;Anatomy;Cell membrane;Cell Survival;Cellular biology;cellular imaging;Clinical Research;Collaborations;Color;Conceptions;Confocal Microscopy;Consultations;Core Grant;Cryopreservation;Cryoultramicrotomy;Data;Drosophila genus;Dyes;Eligibility Determination;Environment;epon;Equipment;Experimental Designs;experimental study;Fluorescein Angiography;Fluorescence;fluorophore;Fostering;Funding;fundus imaging;Grant;Health Services Accessibility;Histology;Histopathology;Human Resources;Image;Image Analysis;Immunofluorescence Immunologic;Institution;instrument;instrumentation;Lasers;light microscopy;Membrane Potentials;Microscope;Microscopy;Ophthalmology;Optical Coherence Tomography;Paraffin;Plastic Embedding;posters;Process;Publications;Research;Research Assistant;Research Personnel;Resources;Retina;Rodent;Sampling;Scanning;Scientist;Services;Slide;slit lamp imaging;Stains;Students;System;Tissue Sample;Tissues;Training;translational study;Universities;Vision;Vision research;vision science;Visual;Work;Zebrafish

PROJECT_TITLE: Imaging and Histopathology core


PROJECT_TERMS: Address;Anatomical Sciences;Anatomy;Area;Basic Science;Cell Separation;Cells;Cellular biology;Collaborations;Communities;Consultations;Core Grant;cost;cytate;Data;Eligibility Determination;Ensure;Environment;Enzyme-Linked Immunosorbent Assay;Eye diseases;Faculty;Flow Cytometry;Fostering;Funding;Genus Hippocampus;Grant;Human Resources;Image;Immunologic Techniques;Immunologics;Immunology;Immunology procedure;innovation;Institution;instrumentation;Methodology;Methods;Ophthalmology;prevent;programs;Research;Research Assistant;Research Personnel;Research Project Grants;Resources;Scientist;Students;supportive environment;tool;Training;Translational Research;Universities;Vision;Vision research;vision science;Western Blotting;Work

PROJECT_TITLE: Immunology core


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics

PROJECT_TERMS: Address;adeno-associated viral vector;Adherence;Anatomical Sciences;Anatomy;Biological;Biological Assay;Cell Line;Cell Maintenance;cell type;Cells;Cellular biology;Collaborations;Consultations;Core Grant;cost;cost effective;cost effectiveness;CRISPR/Cas technology;design;Eligibility Determination;Environment;Equipment;established cell line;experimental study;Fostering;Funding;Gene Silencing;Genotype;Grant;Human Resources;In Vitro;Institution;Maintenance;Mediation;Molecular;Molecular Biology;Molecular Biology Techniques;Nested PCR;Ophthalmology;Polymerase Chain Reaction;Price;Provider;Reactive Oxygen Species;Recombinant adeno-associated virus (rAAV);Recombinants;Recommendation;Research;Research Assistant;Research Personnel;Resources;Reverse Transcription;Scientist;small hairpin RNA;Small Interfering RNA;Students;Techniques;Testing;tissue culture;Tissues;Training;Universities;vector;Virus;Vision;Vision research;vision science;Work

PROJECT_TITLE: Tissue Culture and Molecular core


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: PROJECT NARRATIVE Novel approaches are needed to train and develop clinician scientists pursuing innovative and impactful translational science. Our summer program will provide medical, pharmacy students with didactic and experiential research training to support the translational science workforce and improve public health and also stimulate engagement of underrepresented undergraduate students in CTS.

PI_NAMEs: ALEKSUNES, LAUREN M;GELINAS, CELINE  (contact)

PROGRAM_OFFICER_NAME: KRASNOVA, IRINA N

PROJECT_TERMS: Address;advanced analytics;Applications Grants;Award;Cancer Education Grant Program;career;career development;Case Based Learning;Cities;Clinical Pathways;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Competence;COVID-19 pandemic;Data Science;Development;digital;disadvantaged background;disease heterogeneity;Dissemination and Implementation;Diverse Workforce;Doctor of Philosophy;Early Intervention;economic disparity;Education;Education and Outreach;Educational Curriculum;Educational workshop;educationally disadvantaged;Enrollment;Entrepreneurship;Environment;equity, diversity, and inclusion;Evaluation;experience;faculty mentor;Fostering;Funding Opportunities;graduate student;hands on research;Health;health disparity;health equity;Health Sciences;Hybrids;improved;innovation;Institutional Review Boards;interest;Knowledge;Leadership;Long-Term Effects;Medical;medical schools;Medical Students;meetings;Mentors;Mentorship;New Jersey;New York;novel strategies;outreach;Parents;Participant;Pathway interactions;Persons;Pharmacists;Pharmacy facility;Pharmacy Schools;Pharmacy Students;Physicians;Population;Population Heterogeneity;primary care practice;Process;professional students;programs;Public Health;recruit;Research;Research Project Grants;Research Training;Resources;response;Science;science education;Scientist;student participation;student training;Students;success;summer program;Talents;Technical Expertise;Technology;Training;Training Activity;Training Programs;translational pipeline;Translational Research;translational scientist;treatment response;undergraduate student;Underrepresented Students;underserved community;Universities;virtual;virtual internship;Visit;Vocational Guidance;Wood material

PROJECT_TITLE: 5/6 NJ ACTS: A Platform for Translational Science in New Jersey: CTSA R25 at Rutgers, Biomedical Health Sciences

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-7 (01)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Cardiovascular;Clinical Research;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: PETERSBURG

ORG_NAME: VIRGINIA STATE UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE The proposed Research Supplements to Promote Diversity in Health-Related Research (Diversity Supplements) at the National Institute on Drug Abuse will allow a recent Psychology department graduate Emma Quarles post baccalaureate biomedical and neuropsychological training experiences in preparation for Neuropsychology doctoral program applications. Emma’s pilot project will focus on the association between vigilance and heart rate variability as a function of cannabis use disorder.

PI_NAMEs: KEEN, LARRY D (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Address;Adult;African American;African American population;Award;Biology;Black Populations;Black race;Brain;Cannabis;cardiovascular health;Cardiovascular system;Centers for Disease Control and Prevention (U.S.);Clinical;clinical center;Clinical Research;Clinical Sciences;Cognition;cognitive process;Cognitive Therapy;Communities;Complex;Data;Data Analyses;Development;Discrimination;Disease;Electrocardiogram;Epidemiology;Event;experience;Frequencies;Funding;graduate school;Health;Heart;heart rate variability;heart rhythm;Historically Black Colleges and Universities;Hour;human subject;Individual;innovation;International;Intervention;intervention program;Interview;Legal;Link;Literature;Manuscripts;marijuana use;marijuana use disorder;marijuana user;Measurement;Measures;meetings;Mentors;Mentorship;National Institute of Drug Abuse;Neuroanatomy;neuropsychiatry;Neuropsychology;parent grant;Parents;Participant;Patient Self-Report;Phase;Physiological;Pilot Projects;Postbaccalaureate;Preparation;Prevalence;Prevention strategy;Process;programs;Psychology;Psychopathology;psychosocial;psychosocial stressors;Publishing;Reporting;Research;Research Personnel;Resources;Rest;Sampling;screening;Social Perception;statistics;Stress;stressor;Students;substance use;Testing;tool;Training;treatment strategy;United States;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;Universities;vigilance;Virginia;young adult

PROJECT_TITLE: Emma Quarles NIDA Diversity Supplement Proposal


NIH_SPENDING_CATS: Aging;Clinical Research

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: No PHR

PI_NAMEs: STONE, ARTHUR A (contact)

PROGRAM_OFFICER_NAME: HOROWITZ, TODD S

PROJECT_TERMS: Ecological momentary assessment;Science

PROJECT_TITLE: Advancing the Science and Practice of Ecological Momentary Assessment


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Contraception/Reproduction;Disability Research;Intellectual and Developmental Disabilities (IDD);Women's Health Research

PHR: PROJECT NARRATIVE Adjoa Manu is a promising public health graduate student with the long-term goal of becoming an independent researcher addressing inequities in reproductive health that affect people with disabilities and other minoritized population groups. The research and training proposed in this diversity supplement will prepare her for the next phase of her research career and support NIH's efforts to diversify the health research workforce. Additionally, findings from the proposed research will provide unique insights into strategies for supporting reproductive decision-making among women with developmental disabilities that affect cognition.

PI_NAMEs: HORNER-JOHNSON, WILLI  (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Access to Information;Address;Affect;African American Women;career;career development;Cognition;cognitive disability;Data;Decision Aid;Decision Making;design;Development;Development Plans;Developmental Disabilities;Disabled Persons;doctoral student;experience;Feedback;Feeling;Funding;future implementation;Ghana;Goals;graduate student;Health;Inequity;insight;Joints;marginalized population;Mentors;Minority Groups;National Institute of Child Health and Human Development;Oregon;parent project;Persons;Phase;Planned Pregnancy;Play;Population Group;Pregnancy;Principal Investigator;prototype;Public Health;Public Health Schools;Qualitative Research;reproductive;Reproductive Health;Research;Research Assistant;Research Personnel;Research Project Grants;Resources;Role;Science;service providers;Services;skills;Structure;Surveys;System;Training;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: Understanding and Supporting Reproductive Decisions among Women with Developmental Disabilities that Affect Cognition: Diversity Supplement