NIH_SPENDING_CATS: Cancer;Immunotherapy;Lung;Lymphatic Research;Pulmonary Fibrosis;Skin Cancer

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative Lymph nodes are a primary site for immune activation against malignancy, but are also a frequent site of metastasis, the leading cause of cancer related death. During cancer progression the extracellular matrix (ECM) scaffold that organizes immune cell response in the lymph node is altered, and ECM alterations such as lymph node fibrosis are associated with worse prognosis. This study focuses on investigating αvβ3 integrin as a target to reverse ECM remodeling in the lymph node during the F99 phase and whether targeting similar pathways enhance the effectiveness of immunotherapy during the K00 phase.

PI_NAMEs: BINGHAM, GRACE C (contact)

PROJECT_TERMS: adaptive immune response;Affect;Animal Model;Antigen-Presenting Cells;Antigens;Area;Atomic Force Microscopy;Biochemical;Biology;Biomedical Engineering;Biophysics;Cancer Biology;Cancer Etiology;cancer immunotherapy;Cancer Patient;Cancer Research Project;Cell Physiology;Cell surface;Cell Survival;Cells;Cellular biology;Cessation of life;Chronic;Cicatrix;Clinical;Collagen;Combined Modality Therapy;Complement;Cues;cytokine;Deposition;Development;Disease;Disease Progression;Doctor of Philosophy;draining lymph node;Effectiveness;Ensure;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Fibronectins;Fibrosis;Functional disorder;Future;Genes;Genetic;Goals;healing;Health;Homeostasis;Human;idiopathic pulmonary fibrosis;Image;Immune;immune activation;immune cell infiltrate;Immune Evasion;immunoengineering;Immunology;Immunotherapy;In Vitro;inhibitor;Injury;innovation;Integrin alphaVbeta3;Integrins;interest;interstitial;Knowledge;Learning Skill;Link;lymph node microenvironment;lymph nodes;Lymphocyte;Malignant neoplasm of lung;Malignant Neoplasms;Measures;mechanical force;mechanical signal;Mechanics;mechanotransduction;Mediating;Melanoma;Melanoma patient;Melanoma Tumor;Mentors;Methods;mouse model;Mus;Myofibroblast;Neoplasm Metastasis;Organ;Outcome;pathogen;Pathogenicity;Pathologic;Pathology;Pathway interactions;pharmacologic;Phase;Phenotype;Postdoctoral Fellow;Process;Production;professor;Prognosis;programs;Proliferating;Property;Pulmonary Fibrosis;Research;Research Project Grants;response;Reticular Cell;scaffold;senescence;Series;Signal Transduction;Site;Stromal Cells;Structure;System;T cell infiltration;T cell regulation;T cell response;T-Cell Activation;T-Cell Depletion;T-Cell Development;T-Lymphocyte;Testing;Therapeutic;Tissues;Training;Transcription Coactivator;tumor;tumor immunology;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;Work;wound healing

PROJECT_TITLE: Fibrotic remodeling of lymph nodes disrupts T cell function in fibrosis and cancer


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Millions of youth use e-cigarettes spurred in part by pervasive marketing in brick-and-mortar retail stores. To prevent youth uptake of e-cigarettes and health risks, the proposed project will ask adolescents and young adults to identify appealing and influential characteristics of e- cigarette marketing in the retail environment and address these influences in a counter- marketing lesson. Study findings will also inform e-cigarette-retail-marketing related regulations.

PI_NAMEs: GAIHA, SHIVANI MATHUR (contact)

PROGRAM_OFFICER_NAME: MAYNE, RACHEL G

PROJECT_TERMS: Address;Adolescent;Adolescent and Young Adult;Advertisements;Advertising;Affect;Age;Award;Behavior;Characteristics;combat;Communication;Cross-Sectional Studies;Data;design;Development;Devices;effectiveness evaluation;effectiveness testing;Electronic cigarette;electronic cigarette use;Elements;Environment;evidence base;experimental study;Exposure to;Focus Groups;Future;Gases;Goals;Grant;Health;Incentives;Influentials;Knowledge;Laws;Learning;Legal;Literature;Location;Maps;Marketing;Measures;Mentors;Mentorship;Modeling;multi-component intervention;multidisciplinary;novel;Pathway interactions;Persons;Phase;pilot test;Policies;Predisposition;prevent;Prevention;Prevention program;Price;programs;Randomized;Randomized, Controlled Trials;Regulation;Research;Research Methodology;Research Personnel;Risk;Sales;skills;Statistical Data Interpretation;Statistical Methods;Surveys;Tobacco;tobacco control;tobacco prevention;tobacco regulatory science;Tobacco use;Training;Translating;uptake;vaping;young adult;Youth

PROJECT_TITLE: Countering E-cigarette Marketing in the Retail Environment among Adolescents and Young Adults


ADMINISTERING_IC: AI

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative Respiratory infections of all types represent a worldwide public health crisis, and many of these microorganisms have potential to cause disruptive pandemics with significant morbidity and mortality. The goal of the Biology of Acute Respiratory Infection Gordon Research Conference (BARI-GRC) and seminar (BARI-GRS) is to assemble a multidisciplinary group of researchers committed to understanding the molecular mechanisms that determine pathogenesis of respiratory microorganisms and host susceptibility. The BARI-GRC and GRS will bring together individuals with a wide range of expertise (including microbiologists, immunologists, infectious disease experts and pulmonary medicine experts) from government, industry and academia who would not normally attend the same conferences, providing unparalleled opportunities to share innovative research and foster cross- disciplinary collaborations and mentorship.

PI_NAMEs: MOORE, BETHANY B. (contact)

PROGRAM_OFFICER_NAME: STRICKLER-DINGLASAN, PATRICIA M

PROJECT_TERMS: Academia;Acute Pneumonia;Acute respiratory infection;Address;Age;Animal Model;Bacteria;Biology;Boston;career;career development;Cell Communication;Cells;Cellular biology;Circadian Rhythms;Clinical Medicine;Collaborations;Communicable Diseases;Communities;Complement;Complex;COVID-19 pandemic;Creativeness;Data;design;Development;Discipline;Disease;diversity and inclusion;Economics;Employment Opportunities;empowerment;Environment;Epidemiologist;experience;extracellular;Face;Faculty;Fostering;fungus;Future;Goals;Government;graduate student;host-microbe interactions;Hour;Human;Image;Immune;Immune response;Immunologist;In Vitro;Individual;Industry;Infection;innovation;insight;Integration Host Factors;Intervention;Knowledge;Learning;Lung;Lung infections;Mediating;meetings;Mentors;Mentorship;Michigan;microbial;microorganism;Molecular;Morbidity - disease rate;mortality;multidisciplinary;Nature;Neurologic;Obesity;Organism;Outcome;pandemic disease;Parasites;Participant;pathogen;Pathogenesis;pathogenic bacteria;pathogenic fungus;pathogenic virus;Physicians;Pneumonia;Postdoctoral Fellow;posters;Predisposition;programs;Public Health;public health intervention;Pulmonology;Reaction;Research;Research Personnel;respiratory;Respiratory Tract Infections;Science;Scientist;sex;Signal Transduction;Site;Social Interaction;symposium;System;Therapeutic;therapeutically effective;tool;Training;training opportunity;Underrepresented Populations;Universities;Veterinarians;Virus;Washington;Woman;Work

PROJECT_TITLE: 2024 Biology of Acute Respiratory Infection Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 BJM-D (S2)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Neurosciences;Prevention;Substance Misuse;Tobacco

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Nicotine/tobacco dependence is a major health concern, and mechanistic neurobiological research into addiction mechanisms may lead to novel approaches to tobacco cessation. The goal of this project is to leverage our well- qualified research team, our innovative tools, and our incisive methods to produce newer/better tools for studying nicotinic acetylcholine receptor activity in the context of nicotine dependence. We will then validate and leverage these tools to investigate novel aspects of nicotine dependence.

PI_NAMEs: DRENAN, RYAN MICHAEL (contact)

PROGRAM_OFFICER_NAME: MCCLURE-BEGLEY, TRISTAN DAVID

PROJECT_TERMS: Acute;addiction;Address;Alkaloids;alpha helix;antagonist;Behavior;Behavioral;Behavioral Assay;Biological Assay;biophysical properties;Brain;cholinergic;Chronic;Cigarette;Communities;Complex Mixtures;Data;Dependovirus;desensitization;design;Development;Dopamine;Dose;economic cost;Electronic Nicotine Delivery Systems;Electrophysiology (science);Excision;experience;expression vector;field study;Future;Goals;Habenula;Health;Human Activities;Hypersensitivity;Image;improved;in vivo;Induced Mutation;innovation;Intake;Knowledge;Laser Scanning Microscopy;Learning;Left;Leucine;Ligand Binding;Maintenance;Medial;Mediating;Membrane;Memory;Methods;Molecular Receptor Pharmacology;Moods;Motivation;mutant;Mutation;Neurobiology;Neurons;Nicotine;Nicotine Dependence;nicotine exposure;nicotine self-administration;nicotinic receptor beta2;Nicotinic Receptors;novel;novel strategies;patch clamp;Pathway interactions;Periodicity;Pharmacology;Physiological;Physiology;presynaptic;preventable death;Psychological reinforcement;Public Health;Qualifying;Rattus;receptor;Receptor Activation;receptor function;Recording of previous events;Reinforcement Schedule;reinforcer;Research;Resistance;response;Rewards;Satellite Viruses;Scanning;Self Administration;Series;Signal Transduction;Slice;Smoking;smoking cessation;Synaptic plasticity;Testing;tobacco cessation intervention;Tobacco Dependence;tobacco products;Tobacco use;Tobacco Use Cessation;tool;trafficking;Training;two-photon;vaping;Variant;vector;Viral Vector

PROJECT_TITLE: Viral vectors for desensitization-resistant nAChRs

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

ORG_STATE: NY

PHR: Project Narrative: Metabolic dysregulation is a known hallmark of cancer progression which promotes the survival and growth of aggressive metastatic cancer. However, how oncogenic signals communicate with mitochondrial enzymes to rewire metabolic pathways and stimulate expression of proliferative genes remains unclear. In this proposal we will investigate that a direct communication between mitochondria and nucleus is vital to reprogram the onco- metabolic pathways promoting adaptation and growth of aggressive metastatic cancer.

PI_NAMEs: DASGUPTA, SUBHAMOY  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Aconitate Hydratase;ATP Citrate (pro-S)-Lyase;Automobile Driving;Biological Process;Biomedical Research;cancer cell;Cell Nucleus;Chromatin;chromatin immunoprecipitation;Citrate (si)-Synthase;Communication;Complex;Coupled;Disease;Disseminated Malignant Neoplasm;Enzymes;Event;Gene Expression Profiling;Genes;Genetic Transcription;Glutarates;Growth;high reward;high risk;Knowledge;Literature;Malignant Neoplasms;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolic stress;Metabolism;metabolomics;Mitochondria;Multienzyme Complexes;novel;Nuclear;Oncogenic;Process;programs;Proteomics;pyruvate dehydrogenase;recruit;Reporting;Role;Signal Transduction;Spatial Distribution;transcription factor;transcriptional reprogramming;tumor progression

PROJECT_TITLE: Decoding the nuclear metabolic processes regulating gene transcription


ADMINISTERING_IC: HS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: HANOVER

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE The Dartmouth Learning Health System Embedded Scientist Training and Research (E-STaR) Center will provide scientists with the skills and needed support to complete research studies with patients, clinical teams, and community partners. Studies will focus on improving the availability and quality of healthcare in northern New England. What is learned will be put into clinical practice and shared widely to promote access to high- quality, equitable, person-centered care across the United States.

PI_NAMEs: FOSTER, TINA ;TOSTESON, ANNA N. A. (contact);TOSTESON, TOR D

PROGRAM_OFFICER_NAME: GRIFFIOEN, MARI

PROJECT_TITLE: Dartmouth Learning Health System (LHS) Embedded Scientist Training and Research (E-STaR) Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZHS1 HSR-B (01)]


PI_NAMEs: TOSTESON, ANNA N. A. (contact)

PROJECT_TITLE: Administrative Core


PI_NAMEs: FOSTER, TINA  (contact)

PROJECT_TITLE: Research Education Core


PI_NAMEs: TOSTESON, TOR D (contact)

PROJECT_TITLE: Research and Data Analysis Core


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics

ORG_CITY: DURHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Type 3 lymphocytes—including group 3 innate lymphoid cells (ILC3), IL-17-producing γδ T cells (Tγδ17), and T helper 17 ( TH17) cells—are crucial for a range of functions from mucosal barrier defenses against extracellular pathogens to secondary lymphoid organ formation. Their dysregulated function has also been implicated in various autoimmune diseases, such as multiple sclerosis and Crohn's disease. The proposed study will further our understanding of the regulatory mechanisms governing the development and differentiation of type 3 lymphocytes.

PI_NAMEs: MEHTA, NAREN U (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Affect;Autoimmune Diseases;Bacteria;Bacterial Artificial Chromosomes;Biological Assay;Categories;Cell Differentiation process;Cell Lineage;Cell model;cell type;Cells;Chromatin;CRISPR interference;Crohn's disease;cytokine;Data;Dependence;Development;differentiation in vitro;Distal;Enhancers;Evaluation;Event;experimental study;extracellular;fungus;Genetic Transcription;Genome;Growth;Guide RNA;Helper-Inducer T-Lymphocyte;Homeostasis;IL17 gene;Immune response;In Vitro;in vivo;Inflammatory Bowel Diseases;Interferon Type II;Interleukin-13;interleukin-22;Interleukin-4;Interleukin-5;knock-down;Libraries;Lymphocyte;Lymphoid Cell;Mucous Membrane;Multiple Sclerosis;novel;Nucleic Acid Regulatory Sequences;pathogen;Pathogenesis;Pathogenicity;Pattern;Population;precursor cell;Production;promoter;Regulatory Element;Reporter;response;Role;screening;secondary lymphoid organ;Secondary to;Site;T-Lymphocyte;Technology;Tissues;Trans-Activators;transcription factor;Transfection;Transgenic Mice;Untranslated RNA;vector;Work;γδ T cells

PROJECT_TITLE: Cis-regulatory mechanisms governing RORgt expression in type 3 lymphocytes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Cancer;Digestive Diseases;Hematology;Nanotechnology;Natural Products;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: DUO ONCOLOGY INC

ORG_STATE: PA

PHR: PROJECT NARRATIVE Pancreatic cancer is one of the deadliest solid tumor malignancies. Current treatments cause toxicity and do not effectively penetrate and accumulate in the tumor due to dense, fibrous stroma tissue. Duo Oncology is developing DUO-207, an ultrasmall nanomedicine, that can penetrate and accumulate in dense pancreatic tumors, co-delivering gemcitabine and paclitaxel directly to the tumor to improve treatment outcomes.

PI_NAMEs: EICHINGER, KATHERINE MARIE (contact)

PROGRAM_OFFICER_NAME: POND, MONIQUE ADRIANNE

PROJECT_TERMS: Abraxane;Address;Advanced Development;advanced pancreatic cancer;Binding Proteins;Biochemistry;Biological Availability;Biological Markers;Blood;Breast;C57BL/6 Mouse;cancer cell;cancer therapy;cancer type;Canis familiaris;Cells;Clinical;clinical efficacy;Compensation;Complete Blood Count;copolymer;Cytidine Deaminase;Data;Death Rate;Development Plans;Diagnosis;Dose;Dose Limiting;efficacy evaluation;efficacy study;Encapsulated;European;Exposure to;Extravasation;falls;Feedback;gemcitabine;Genetic Engineering;Goals;Grant;Hematology;improved;Incidence;innovation;Intravenous infusion procedures;irinotecan;Legal patent;leukemia;Link;Liposomes;Liver;Lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Maximum Tolerated Dose;Medical;Medicine;Micelles;Modeling;Monitor;mouse model;Mus;nanomedicine;nanoparticle;nephrotoxicity;novel;Oncology;Operative Surgical Procedures;Organ;Orphan Drugs;Outcome;Paclitaxel;pancreatic cancer model;pancreatic cancer patients;pancreatic neoplasm;particle;Pathology;Patients;Penetration;Pharmaceutical Preparations;Pharmacotherapy;Phase;phase 1 study;Polymer Chemistry;Polymers;pre-clinical;preclinical study;prognostic;prospective;Quality of life;Randomized;Regimen;Regulatory Pathway;Resected;response;Safety;Saline;self assembly;Serum;sex;Solid Neoplasm;standard of care;stem;survival outcome;Survival Rate;Tail of pancreas;Testing;Therapeutic;Time;Tissues;Toxic effect;Toxicokinetics;Toxicology;Treatment outcome;tumor;tumor growth;tumor microenvironment;Tumor Tissue;Tumor Weights;ultrasound;Work

PROJECT_TITLE: Stroma-penetrating nanomedicine to improve treatment for pancreatic cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-E (11)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: BLOOMINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Wolbachia pipientis is a bacterium that infects insect hosts, where it inhibits virus replication. Our proposed studies aim to identify exactly how Wolbachia manipulates the host to establish an infection. Discoveries made as part of this work will be directly applicable to the use of Wolbachia to control disease vectors.

PI_NAMEs: NEWTON, IRENE  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Actins;Aedes;Alphaproteobacteria;Arbovirus Infections;Bacteria;Biological Assay;Biology;Bundling;Cell Culture Techniques;Cell Line;Cells;Cellular biology;Communicable Diseases;Coupled;CRISPR screen;Culicidae;Cytoskeleton;Data;Death Rate;Dengue Virus;differential expression;Disease Vectors;disorder control;Drosophila genus;Drosophila melanogaster;Electron Microscopy;Endocytosis;Environment;Evolution;Flow Cytometry;fly;Genetic;genetic manipulation;Goals;Homologous Gene;host colonization;human disease;Immunohistochemistry;In Vitro;infancy;Infection;Insecta;Invaded;Mediating;Membrane;Microbe;Modeling;Molecular;Molecular Biology;Molecular Evolution;mosquito-borne pathogen;mutant;nanomachine;next generation;Parasites;pathogen;pathogenic bacteria;Pathway interactions;Persons;Phenotype;Planet Earth;Planets;prevent;Process;programs;Proteins;Proteomics;receptor recycling;Reproduction;Research;RNA Interference;RNA Viruses;symbiont;Symbiosis;synuclein;Tertiary Protein Structure;trafficking;transmission process;Trees;Type IV Secretion System Pathway;Vaccines;vector competence;vector control;Vesicle;Viral;Virus;Virus Replication;Visualization;Wolbachia;Work

PROJECT_TITLE: Identifying Wolbachia effectors that facilitate host infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-U (02)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE The liver mitochondria function as a vital source of gluconeogenic precursors under a fasted state. We recently identified a liver-specific mitochondrial carrier, SLC25A47, that plays a crucial role in the process. Building upon the discovery, this proposal aims to understand the underlying mechanisms of SLC25A47 action in the regulation of energy expenditure and glucose homeostasis. Successful completion of this study will offer a liver-specific target through which we can restrict hepatic gluconeogenesis, which is often in excess under hyperglycemic and diabetic conditions, while elevating energy expenditure. Importantly, this work will establish a framework to understand the principle of tissue-specific mitochondrial metabolite transport in physiology and disease.

PI_NAMEs: KAJIMURA, SHINGO  (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Address;Biological;blood glucose regulation;Carrier Proteins;Cell-Free System;Cues;Data;diabetic;Disease;Energy Metabolism;Family;Fasting;Fatty acid glycerol esters;feeding;Generations;Genomics;Gluconeogenesis;hepatic gluconeogenesis;Hepatocyte;Homeostasis;Hormonal;Hyperglycemia;Inner mitochondrial membrane;Label;Lead;Liver;Liver Mitochondria;Malates;Mediating;member;Membrane;Metabolic Diseases;Mitochondria;Nature;Nutritional;Obese Mice;Obesity;Organelles;Orphan;Pattern;Physiology;Play;Portal vein structure;Process;programs;proteoliposomes;Proteomics;Pyruvate;reconstitution;Regulation;Reporter;Role;selective expression;Signal Transduction;Source;System;Testing;Therapeutic;Therapeutic Effect;Thermogenesis;Tissues;Transcriptional Regulation;transcriptomics;uncoupling protein 1;Work

PROJECT_TITLE: A liver-specific mitochondrial carrier that controls energy homeostasis

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Disability Research;Hearing Loss

ORG_CITY: Rockville

ORG_NAME: HEARING LOSS ASSOCIATION OF AMERICA

ORG_STATE: MD

PHR: PROJECT NARRATIVE Hearing loss affects an estimated 48 million Americans. This project aims to spread information about hearing loss research by supporting the convening of a high quality, communication-accessible Research Symposium at each Hearing Loss of Association of American (HLAA) annual convention and disseminating professionally edited videos of the symposia to the wider community of people with hearing loss and their families, and the general public. This will allow a wide audience will be able to be engaged in the science underlying this key public health issue.

PI_NAMEs: KELLEY, BARBARA  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Adult;Advocacy;Affect;American;American Sign Language;Communication;Communities;Congresses;digital communication;digital media;Education;Electronic Mail;Event;Family;Funding;General Population;Health;Hearing;hearing impairment;hearing screening;improved;Influentials;innovation;meetings;member;Mission;Multimedia;National Institute on Deafness and Other Communication Disorders;patient engagement;Persons;Policy Making;Professional Organizations;programs;Public Health;Research;Research Personnel;Research Support;Resources;Science;scientific organization;Scientist;Self-Help Devices;Site;Spottings;Support Groups;symposium;Testing;Time;United States;United States Federal Trade Commission;United States Food and Drug Administration;Voice;Work

PROJECT_TITLE: Research Symposia at the Annual Convention of the Hearing Loss Association of America

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BALTIMORE

ORG_NAME: BALTIMORE VA MEDICAL CENTER

PHR: VA is transforming to Whole Health (WH), health care that is “personalized, proactive, and patient-driven.” Social and cultural factors such as Veteran identity and culture (VIC) and racial identity and culture (RIC) influence patient and provider behaviors, concepts of health, and approaches to power sharing and decision making. This can create partnerships or conflicts and influence WH care. In this study researchers from Howard University (HU), a Minority Serving Institution (MSI), and VA will use narrative inquiry methods to interview 15 Black and 15 White Veterans who participated in a WH education and activation intervention. The interviews will (1) explore perceived barriers and facilitators to Veterans' participation in WH related to their VIC and RIC; (2) understand similarities and distinctions in barriers and facilitators among Black and White Veterans; (3) identify VIC- and RIC-informed guidance about what promotes or prevents participation in WH. This project will also promote partnerships between VA and HU scientists to enhance diversity in VA research.

PI_NAMEs: HACK, SAMANTHA  (contact)

PROJECT_TERMS: Articulation;aspirate;Awareness;Behavior;Belief;black patient;Black race;Capital;career;Caring;Clinical;clinical encounter;Code;Communication;cultural health;Data;Data Analyses;Data Set;Decision Making;design;Education;efficacy testing;Elements;Ensure;Evaluation;Event;experience;Faculty;Failure;Funding Mechanisms;Health;Health Benefit;Health education;health goals;Health Status;Healthcare;implicit bias;Individual;individual patient;insight;Institute of Medicine (U.S.);Institution;Intervention;Interview;Interviewer;Learning;Life;Literature;Lived experience;maladaptive behavior;Medical;meetings;member;Mental Health;Methods;Minority-Serving Institution;Mission;Motivation;next generation;Outcome;Parents;Participant;patient oriented;Patient Participation;Patient Preferences;Patient-Centered Care;Patients;Perception;Personal Satisfaction;Persons;prevent;Procedures;Process;Provider;provider behavior;racial bias;racial disparity;racial identity;racial population;Randomized;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Personnel;resilience;Role;Sampling;Scientist;Self Care;self reliance;Semantics;skills;social;social culture;Social support;Standardization;stress reduction;Structure;Supervision;Techniques;telehealth;Testing;Training;United States Department of Veterans Affairs;Universities;university student;Veterans;Voice;whole health;willingness;Work

PROJECT_TITLE: Whole Health in VA Mental Health: A Randomized Controlled Trial of Omnis Salutis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 DEIR-N (01)]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Machine Learning and Artificial Intelligence;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: Project Narrative Even after the COVID-19 pandemic, influenza continues to have a significant impact on public heath affecting over 35 million people, causing 710,000 hospitalizations and about 47,000 deaths per year in the United States. The strongest public health response to influenza remains the annual vaccine, the effectiveness of which is calculated each year by the Centers for Disease Control (CDC), and while these vaccine effectiveness (VE) estimates are the US gold standard, they have limitations due to the inclusion of only a limited number of regions and subjects, as well as the interim report not being published until late into the flu season. We propose the use of longitudinal social media (SM) data and state of the art Natural Language Processing techniques to develop and evaluate a near real-time VE estimation system that accounts for biases, uncertainty, and missing data in vaccination status or influenza diagnosis which, if successful, will be the first automated approach to near real-time estimation of vaccine effectiveness in the United States.

PI_NAMEs: GONZALEZ HERNANDEZ, GRACIELA  (contact);SCOTCH, MATTHEW

PROGRAM_OFFICER_NAME: WANG, YANLI

PROJECT_TERMS: Address;Affect;Age;age group;Agreement;Arizona;authority;Award;Cause of Death;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;Child;Clinic;Code;cohort;Collaborations;Communicable Diseases;Communication;comorbidity;cost;COVID-19;COVID-19 pandemic;Data;data quality;Data Set;design;Diagnosis;Disease;Effectiveness;effectiveness validation;Enrollment;Epidemiology;flu;Funding;Health;high risk;Hospitalization;human old age (65+);Immunity;Immunocompromised Host;improved;inclusion criteria;Individual;Infant;Infection;Influenza;influenza epidemic;Influenza vaccination;influenza virus vaccine;interest;Joints;Letters;Longitudinal cohort;manufacture;Manuscripts;Measures;Methods;Mining;model design;Monitor;Morbidity - disease rate;mortality;Natural Language Processing;outreach;pandemic disease;Participant;Performance;Persons;pharmacovigilance;Population;Pregnant Women;Public Health;Publications;Publishing;Readiness;Recommendation;Reporting;Reproducibility;residence;response;Running;Sampling;seasonal influenza;Seasons;Site;social media;success;System;Techniques;Test Result;Testing;Time;timeline;Twitter;Uncertainty;United States;United States National Institutes of Health;Vaccination;vaccine effectiveness;vaccine trial;Vaccines;Work;World Health Organization

PROJECT_TITLE: Real-time estimation of influenza vaccine effectiveness through social media mining

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: The regulation of hematopoietic stem cells (HSC) during bone marrow regeneration are poorly understood. The functional decline of HSC after bone marrow transplantation is thought to be a degenerative process caused by accumulated damage that leads to cellular dysfunction, tissue failure, and death. Evidence has now proven that there is a measurable changes in HSC metabolism after bone marrow transplantation that drive HSC functional decline. The studies proposed in this application will provide information on cellular factors that become deregulated in hematopoietic stem cells after bone marrow transplantation and cause functional decline of the hematopoietic tissue, and will identify conditions under which HSC can be maintained with full regenerative potential. This could be a first step towards designing treatments to improve HSC function during bone marrow regeneration to improve bone marrow transplant outcomes.

PI_NAMEs: FILIPPI, MARIE-DOMINIQUE  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Address;Applications Grants;Automobile Driving;Autophagocytosis;Biological Assay;Blood;Blood Cells;Bone Marrow;Bone marrow failure;Bone Marrow Transplantation;candidate validation;Carbon;CD34 gene;Cell Cycle;Cell Nucleus;Cells;Cellular Metabolic Process;Cessation of life;Communication;curative treatments;daughter cell;Defect;Engraftment;Enzymes;Excision;experimental study;Failure;Folic Acid;functional decline;Functional disorder;gain of function;Genetic;Goals;Hematological Disease;hematopoietic engraftment;hematopoietic stem cell self-renewal;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;hematopoietic tissue;Human;human model;Immune;immunodeficiency;Impairment;improved;in vitro Assay;in vivo;Injury;insight;Intervention;Knowledge;Life;Link;loss of function;Measurable;Measures;Metabolic;Metabolism;Mitochondria;mitochondrial metabolism;mouse model;Mus;Natural regeneration;novel;novel strategies;Outcome;Pathway interactions;pharmacologic;Population;post-transplant;prevent;Process;Production;programs;Property;protein expression;protein metabolite;Quality Control;regeneration potential;Regenerative capacity;Regulation;Regulatory Pathway;Reporter;Reporting;Research;restoration;Role;self-renewal;Shapes;Signal Transduction;stem cell engraftment;stem cell function;stem cell proliferation;stem cell self renewal;stem cells;Stress;Supplementation;System;Testing;therapeutic target;therapy design;Tissues;transplant model;Transplant Recipients;Transplantation;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Regulatory mechanisms of hematopoietic stem cell functions post-transplant

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: PHILADELPHIA

ORG_NAME: MYEXPOSOME, INC.

PHR: Project Narrative This proposal will make silicone wristband chemical samplers available in the consumer market and increase the impact of personalized exposure data. The project will lower costs and allow users of silicone wristbands (SWBs) to distinguish chemical sources from the air and skin and facilitate comparisons of SWB data to regulatory exposure limits or other studies. Project results will expand the use of SWBs to motivated consumers, researchers, and risk assessors that can use these data and subsequent personalized chemical reports to reduce or eliminate sources of unwanted exposure.

PI_NAMEs: O'CONNELL, STEVEN GEHRIG (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: absorption;Address;Adoption;Air;Atmosphere;Back;Benchmarking;candidate identification;Chemical Exposure;Chemicals;Communication;Communication difficulty;Communities;cost;Cost Analysis;Data;data communication;data reduction;Data Set;Dermal;dermal exposure;Development;Environmental Monitoring;experience;exposure route;Feedback;Flame Retardants;Food;Goals;improved;Individual;interest;Internet;Logistic Models;Maintenance;Market Research;Marketing;Measures;Modeling;Monitor;new technology;novel;Organic Chemicals;Paper;Participant;Pattern;personal care products;Persons;Pesticides;Phase;Phase I Clinical Trials;phthalates;Positioning Attribute;predictive modeling;Price;Property;Publications;Publishing;Reporting;Research;Research Personnel;Risk;Risk Assessment;Route;Sales;Sample Size;Sampling;Science;Services;Silicones;Skin;Small Business Innovation Research Grant;Source;Surface;System;Technology;tool;Training;uptake;Visualization;Volatilization;Work;wristband

PROJECT_TITLE: Development of a Route of Exposure Model Using Silicone Wristbands as Personal Samplers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-S (13)]


ORG_DEPT: GENETICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Our program is called Promoting Embedded Research in a Learning Health System (PERLHS). With an administrative core, a research education core, and a research and data analytics core, we aim to build the comparative effectiveness research skills of embedded clinicians, scientists, and administrators. We will engage three distinct populations of scholars: learners embedded within the precision-medicine initiative of Johns Hopkins University, learners embedded within the operational entities of the Johns Hopkins Health System, and learners embedded in entities working to advance population health for Maryland residents.

PI_NAMEs: MARSTELLER, JILL ANNE;SEGAL, JODI B. (contact)


PI_NAMEs: SEGAL, JODI B. (contact)

PROJECT_TITLE: Admin


PI_NAMEs: LEHMANN, HAROLD P. (contact)


NIH_SPENDING_CATS: Autoimmune Disease;Data Science;Diabetes;Networking and Information Technology R&D (NITRD)

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative The overall goal of this project is to develop PanKbase, a centralized and comprehensive resource of the human pancreas for the diabetes research community, with a focus on type 1 diabetes (T1D) pathogenesis. If successful, results from this project will provide new insights into T1D pathogenesis and enable the development of new therapies and biomarkers. The project will also foster cross-disciplinary collaborations and promote innovation, with the ultimate aim of improving the lives of people with T1D.

PI_NAMEs: BRISSOVA, MARCELA ;CARTAILLER, JEAN-PHILIPPE ;CHEN, SHUIBING ;LIU, JIE ;PARKER, STEPHEN CJ (contact);STITZEL, MICHAEL LEE

PROGRAM_OFFICER_NAME: XIA, ASHLEY

PROJECT_TERMS: Acceleration;analytical tool;Architecture;Area;base;Biological Markers;Biology;Biometry;Caring;cell type;Cells;Charge;Clinical;Clinical Trials;cloud based;Collaborations;Collection;Communities;community engagement;Community Networks;Community Surveys;complex data;Conduct Clinical Trials;Creativeness;Data;Data Commons;data modalities;Data Science;Data Scientist;Data Set;Databases;Dedications;design;Development;Diabetes Mellitus;diabetes pathogenesis;Diabetes prevention;Disease;diverse data;Drug Industry;Ecosystem;endophenotype;Engineering;Ensure;Etiology;Europe;FAIR principles;Feedback;Fostering;Foundations;Functional disorder;Funding;Future;Generations;Genetic;genetic association;Genomics;Goals;graph knowledge base;heterogenous data;Human;Human Resources;Image;Imaging technology;Immune;improved;innovation;insight;Insulin-Dependent Diabetes Mellitus;International;islet;Islets of Langerhans;Knowledge;knowledge graph;knowledgebase;Lead;learning community;Libraries;Machine Learning;meetings;member;Metadata;Modality;Modernization;Molecular;Molecular Profiling;multidisciplinary;multimodal data;multimodality;multiplexed imaging;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;novel diagnostics;novel therapeutics;Ontology;Organ;Pancreas;Participant;Persons;Phenotype;Physiological;Population;prevent;Process;Productivity;programs;Property;Provider;Quality Control;Reproducibility;Research;Research Personnel;Resolution;Resources;Sampling;Scientist;single cell sequencing;spatial relationship;Standardization;synergism;Technology;tissue mapping;Tissues;tool;tool development;United States;user-friendly;Visualization;web interface;Work

PROJECT_TITLE: PanKbase: a community hub for integrated pancreas knowledge

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-J (O1)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Master transcriptional regulators are critical for the proper function and maintenance of human stem cells. During blood cell production, dysregulation of the transcription factor MECOM can greatly disrupt normal differentiation of hematopoietic stem and progenitor cells and is thus implicated in aggressive forms of blood cancer. Here, I will use biochemical and genomic approaches to define the direct transcriptional targets of MECOM in acute myeloid leukemia and functionally dissect mechanisms by which MECOM exerts control over this gene regulatory network to ultimately elucidate novel therapeutic targets for the treatment of high-risk leukemias.

PI_NAMEs: FLEMING, TRAVIS J (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Ablation;Academic skills;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Award;Binding;Binding Sites;Biochemical;Bioinformatics;Biomedical Research;Blood Cells;Boston;Cancer Biology;career;career preparation;Cell Differentiation process;Cell Line;Cell Maintenance;Cell Survival;Cells;Chemicals;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Communication;conventional therapy;Data;design;Development;Differentiated Gene;Disease;Engineering;Environment;Epigenetic Process;Equilibrium;experience;experimental study;Family;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;gene network;gene regulatory network;gene repression;Genes;Genetic;genetic corepressor;Genetic Identity;Genetic Transcription;Genomic approach;Genomics;Goals;Hematologic Neoplasms;Hematological Disease;Hematopoiesis;hematopoietic differentiation;Hematopoietic Neoplasms;Hematopoietic stem cells;high risk;Human;human stem cells;improved;Individual;insight;Knowledge;leukemia;leukemia treatment;Leukemic Cell;leukemic stem cell;leukemogenesis;Maintenance;Malignant Neoplasms;Mediating;medical schools;Mentors;Modeling;Molecular;Molecular Abnormality;Molecular Profiling;Myelogenous;Myeloid Cells;Myeloproliferative disease;new therapeutic target;novel;novel therapeutics;Outcome;Pathogenesis;Pathway interactions;Patients;Pediatric Hospitals;Production;Prognosis;programs;Protein Family;recruit;Recurrent disease;Reporting;Repression;Research;risk stratification;Sampling;Scientist;Site;small molecule;stem cell fate;stem cell genes;stem cells;survival outcome;targeted treatment;Therapeutic;Therapeutic Intervention;Training Programs;transcription factor;Translating;Variant;Work

PROJECT_TITLE: Functionally dissecting MECOM gene regulation in high-risk leukemia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09A-R (20)]


ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative Residual tumor cells that survive oncogene targeted therapies pose a challenge to achieving durable responses since these cells often serve as the reservoir for tumor relapse and progression. We recently found that residual cells evade immune recognition by targeting macrophages of the immune system. In this proposal, we propose a series of mechanism-based approaches to uncover potential targets to engineer the immune-mediated clearance of residual tumor cells.

PI_NAMEs: RAJ, JUDE  (contact)

PROJECT_TERMS: Antibodies;Antineoplastic Agents;antitumor effect;Automobile Driving;Biological;BRAF gene;cancer cell;Cancer cell line;Cancer Model;Cell Survival;Cells;clinical practice;Clinical Trials;Combined Modality Therapy;CRISPR screen;Data;driver mutation;Eating;Event;Exhibits;Flow Cytometry;functional genomics;Genomic approach;Human;human model;Immune;Immune Evasion;Immune system;Immunodeficient Mouse;immunoengineering;Immunologic Surveillance;Immunologics;Impairment;In Vitro;in vivo;in vivo Model;inhibitor;inhibitor therapy;Investigation;KRAS2 gene;Lead;Link;Macrophage;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;Membrane Proteins;Modeling;Molecular;Mus;mutant;Mutant Strains Mice;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;Oncogenes;Patients;Phagocytosis;Pharmaceutical Preparations;Phenotype;Play;Process;Progressive Disease;Property;protein expression;Recurrence;Relapse;Reproducibility of Results;Residual Cancers;Residual Neoplasm;Residual state;Resistance;response;Role;Sampling;Series;Signal Transduction;Study models;Surface;synergism;targeted treatment;Testing;Tissues;transcriptomics;treatment response;tumor;Tumor Escape;Tumor-associated macrophages;Up-Regulation;Work

PROJECT_TITLE: Mechanisms of Macrophage-Mediated Immune Evasion in Residual Tumors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (20)]


ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This project will use adeno-associated viral vectors guided by nanobodies or peptides to deliver HIV-1 specific recombinase-based effector molecules to inactivate the HIV proviral DNA in persistently infected human T cells and myeloid cells. The significance is a clinically-viable non-invasive systemic approach to kill HIV in all tissues including the CNS without harming the host.

PI_NAMEs: KUMAR, PRITI  (contact);LANGE, ULRIKE C.

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Address;adeno-associated viral vector;Affinity;Animal Model;antiretroviral therapy;Autologous;Automobile Driving;Binding;Biodistribution;Biological Assay;Blinded;Capsid;CD4 Positive T Lymphocytes;CD7 gene;Cell model;cell type;Cells;Central Nervous System;Chimeric Proteins;Chromosomes;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;CRISPR/Cas technology;cytotoxicity;Dependovirus;design;Development;Directed Molecular Evolution;DNA;DNA Modification Methylases;DNA Sequence;DNMT3a;Engineering;Enterobacteria phage P1 Cre recombinase;Enzymes;Epigenetic Process;epigenetic silencing;epigenome;Evaluation;FDA approved;first-in-human;Future;Gene Delivery;gene therapy;gene therapy clinical trial;Gene Transduction Agent;Genetic Recombination;Genetic Transcription;genetically modified cells;Genome;genome editing;genotoxicity;Germany;Guide RNA;Hematopoietic stem cells;HIV;HIV Genome;HIV Infections;HIV-1;HIV/AIDS;Human;humanized mouse;Immune;immunogenic;immunogenicity;in vivo;Infection;insertion/deletion mutation;Intervention;large cell Diffuse non-Hodgkin's lymphoma;Macrophage;Measurement;Microglia;monocyte;mouse model;Mus;Myelogenous;Myeloid Cells;nanobodies;nanoluciferase;new technology;next generation sequencing;novel;nuclease;Peptides;Peripheral;Persons;Phase;Phase I/II Clinical Trial;Physiological;pre-clinical;preclinical study;prevent;Promoter Regions;Provirus Integration;Proviruses;receptor binding;recombinase;Reporter;resistance mutation;response;Rest;Risk;Serotyping;Source;Specificity;success;Surface;System;T memory cell;T-Lymphocyte;targeted delivery;Techniques;Testing;Therapeutic;therapeutic gene;Tissues;Toxic effect;transcriptome;transgene expression;Transplantation;Tropism;vector;Viral;viral rebound;Viral reservoir;Viral Vector;Virus;virus testing;Withdrawal;Zinc Fingers

PROJECT_TITLE: Capsid-engineered AAV vectors with Brec1-based gene therapeutics for inactivating the HIV reservoir

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 BJM-A (S1)]


ADMINISTERING_IC: EY

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Complementary and Integrative Health;Dietary Supplements;Eye Disease and Disorders of Vision;Natural Products;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_CITY: FORT WORTH

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Corneal scarring is a major cause of blindness in the world today but its epidemiology is proven to be very complicated and dependent on a variety of factors, including trauma, infections, and inflammation. Currently, and for the last four decades, the only available treatment for corneal scarring is corneal transplantation; however, this therapy has significant side effects and concerns. We propose to determine whether flavonoids, and novel synthetic flavonoids (sFNs) can be developed and utilized as therapeutic agents to mitigate or reverse corneal scarring.

PI_NAMEs: EMMITTE, KYLE A;KARAMICHOS, DIMITRIOS  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 3-Dimensional;Actins;Affect;analog;Animal Model;Biochemical;Biological;Blindness;career;Cell Culture Techniques;Childhood;Cicatrix;Complex;Cornea;corneal epithelial wound healing;Corneal Injury;corneal scar;Data;design;Development;DNA Repair;drug development;drug discovery;efficacy evaluation;Epidemiology;Equilibrium;Evaluation;Event;Extracellular Matrix;Eye;Eye Injuries;Fibrosis;Financial cost;Flavonoids;Foundations;Future;Goals;Graft Rejection;high reward;high risk;Homeostasis;Human;human model;improved;In Vitro;Infection;Inflammation;Injury;Keratoplasty;Libraries;Luteolin;Maintenance;Marketing;Metabolism;Modeling;Molecular;Normal tissue morphology;novel;novel therapeutics;Operative Surgical Procedures;Optics;Patients;Persons;Phenotype;prevent;Procedures;Process;process optimization;Property;Publishing;Quality of life;Quercetin;restoration;Risk;scaffold;screening;self assembly;Series;side effect;sight restoration;Signal Pathway;Signal Transduction;Smooth Muscle;Solubility;standard care;stem;Structure;Surface;Techniques;Testing;Therapeutic Agents;Therapeutic Intervention;Tissues;tool;Trauma;Ulcer;Vision;Work;wound healing

PROJECT_TITLE: Discovery of synthetic flavonoids for the treatment of corneal injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Rural Health;Social Determinants of Health;Urologic Diseases

ORG_NAME: SONOVANCE, INC.

PHR: NARRATIVE Ultrasound technology, which may be the most cost-effective device for the improvement of global health, today requires the operator to see the currently scanned images, guiding acquisition by anatomy mastered by rigorous training. The proposed technology develops low- cost hardware, requires no anatomic training, instead guiding even a lay operator with more easily learned graphical clues, till data acquisition is complete and can be passed to an examining physician in a format familiar to her from other radiological images. This system allows efficient resource management of skilled ultrasonography consultants, who are in short supply not only in rural and battlefield environments, but also in emergency and operating room medicine, and can dramatically increase access to life-saving U/S diagnostics both here in the U.S. and in the world.

PI_NAMEs: DAHL, JEREMY ;RAGHAVAN, RAGHU  (contact)

PROGRAM_OFFICER_NAME: ASHMONT, KARI RICH

PROJECT_TERMS: 3-Dimensional;Abdomen;Acceleration;Accident and Emergency department;Acute;Address;anatomic imaging;Anatomy;Appearance;Bladder;Businesses;Calculi;Calibration;Cardiac;Caring;Chronic Kidney Failure;Clinic;Clinical;clinical imaging;Clinical Services;Clinical Trials;Clinics and Hospitals;Computer Models;Computer software;cost;cost effective;COVID-19 pandemic;Cyst;Data;data acquisition;Development;Devices;Diagnosis;Diagnostic;Diagnostic Imaging;Discipline of Nursing;Electromagnetics;Emergency department visit;Environment;experience;Feedback;Future;global health;Goals;Grant;handheld mobile device;Health Services Accessibility;Health system;Healthcare;Home;Hospitals;Human;Human Volunteers;Image;image processing;image reconstruction;imaging system;improved;Individual;innovation;interest;Intervention;Kidney;Kidney Calculi;kidney imaging;Knowledge;Learning;Legal patent;Life;Location;Maryland;Measurement;Medical Imaging;Medicine;Methods;Mission;Modeling;National Institute of Biomedical Imaging and Bioengineering;Nature;Nurses;Nursing Homes;Obstruction;Operating Rooms;Organ;Outcome;Parameter Estimation;patient home care;patient population;Patients;Phase;Physicians;Pilot Projects;Point of Care Technology;portability;Positioning Attribute;prevent;Procedures;Process;product development;programs;Protocols documentation;prototype;radiological imaging;Reporting;Research;Resolution;Resources;Rural;rural area;rural health clinic;Scanning;sensor;sensor technology;Services;signal processing;Signal Transduction;skills;software development;System;targeted imaging;Technology;technology platform;Testing;Three-Dimensional Image;Training;Ultrasonography;ultrasound;underserved area;urgent care;Urinary tract;usability;visual feedback

PROJECT_TITLE: Low-Cost Ultrasound Imaging for In-Home, Rural, and Clinic Care Without The Need For Trained Staff

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-Z (10)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: ROCKVILLE

ORG_NAME: FINA BIOSOLUTIONS, LLC

PHR: Malaria is caused by a parasite with a complex lifecycle, including a blood stage in which the parasite binds and enters red blood cells: A mosquito acquires malaria from the blood during feeding and transmits the parasite on biting its next victim. Transmission-blocking vaccines induce antibodies that will block parasite passage through the mosquito; both transmission-blocking and blood-stage vaccine antigens have been identified, but, to date, they have only been produced in expensive eukaryotic systems. We propose to produce these antigens as genetic fusions in our engineered E. coli strain, which can make soluble, complex proteins in the cytoplasm at high levels, allowing us to manufacture a low-cost malaria vaccine targeting multiple elements of the malaria parasite lifecycle.

PI_NAMEs: LEES, ANDREW  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Affinity;analytical method;Antibodies;Antibody Response;antigen challenge;Antigens;Bacteria;Baculoviruses;Binding;Biological Assay;biophysical analysis;Bite;Blocking Antibodies;Blood;Carrier Proteins;Cell Density;Cessation of life;chemical conjugate;chemical synthesis;Chemicals;Child;Chimeric Proteins;Clinical;Complex;cost;Country;cross reacting material 197;crosslink;Culicidae;Cytoplasm;design;Development;disulfide bond;Documentation;Elements;Engineering;Enzyme-Linked Immunosorbent Assay;Erythrocytes;Escherichia coli;Eukaryotic Cell;Evaluation;expression vector;Falciparum Malaria;feeding;Fermentation;Fusion Protein Expression;gene cloning;gene synthesis;Genetic;glycosylation;Goals;Growth;High Pressure Liquid Chromatography;Home;Immune Sera;immunogenic;immunogenicity;Immunology;Ion-Exchange Chromatography Procedure;Laboratories;Life Cycle Stages;Link;Malaria;Malaria Vaccines;manufacture;Manufacturer;Membrane;Metals;Molecular Conformation;Monoclonal Antibodies;monomer;Mus;Mutate;nanoparticle;neutralizing antibody;nonhuman primate;novel;Parasites;Phase;Plasmodium falciparum;prevent;Price;protein complex;protein folding;protein purification;Proteins;Public Health;Research Project Grants;Sahara;scale up;Site;Small Business Innovation Research Grant;Solubility;Structure;System;transmission blocking;transmission process;transmission-blocking vaccine;Trefoil Motif;United States National Institutes of Health;Universities;Vaccine Antigen;vaccine-induced antibodies;Vaccines;vaccinology;web site;Western Blotting;Yeasts

PROJECT_TITLE: E. coli platform for expression of low-cost malaria fusion proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-D (10)]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: Bethesda

ORG_NAME: INSILICA, LLC

PHR: The Phase I SBIR objective is to design, develop, & demonstrate feasibility of BioBricks-Env, an artificial intelligence (AI) driven, open-source, modular, composable platform to organize, store, retrieve, extract, and integrate environmental health & risk related data. Data loading is a universal barrier to building data sources, models, and informatics tools that leverage existing sources, as this phase of research is tedious, error prone, costly, and difficult to scale across projects. Therefore, new AI technologies that can rapidly scale and reduce redundancies for storing, retrieving, extracting, and integrating data related to chemical exposure, environmental health, and human health risks could transform the market landscape.

PI_NAMEs: LUECHTEFELD, THOMAS  (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: Adopted;Adoption;Agrochemicals;Architecture;Artificial Intelligence;Bioinformatics;Biological;Catalogs;Chemical Exposure;Chemicals;Code;commercialization;complex data;Computational Biology;computerized tools;Cosmetics;cost;Custom;Data;data harmonization;data integration;data pipeline;data registry;data resource;Data Science;Data Scientist;Data Sources;Databases;Dependence;design;Development;digital;Disparate;Ensure;Environment;Environmental Health;Environmental Risk Factor;Health;health data;Home;Human;Industry;Informatics;informatics tool;innovation;interoperability;knowledgebase;Laboratories;Link;Linux;Machine Learning;Maps;Marketing;Methodology;Methods;Modeling;new product development;novel strategies;open source;open source tool;Output;Performance;Phase;Process;Protocols documentation;prototype;public database;Public Health;Research;Research Personnel;Resources;Risk;Risk Assessment;Running;Safety;Scientist;Service delivery model;Services;Small Business Innovation Research Grant;software as a service;Source;Standardization;success;Technology;Testing;Time;tool;Toxic effect;Toxicology;Update;usability;validation studies;Work;Writing

PROJECT_TITLE: BioBricks-Env: AI driven, open-source, modular, composable platform to organize, store, retrieve, extract, and integrate environmental health & risk related data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (14)]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Physical Activity;Prevention;Rehabilitation;Sleep Research;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative Fear of cancer recurrence (FCR) is arguably the single most commonly shared adverse psychosocial effect of cancer and its treatment across all cancer populations, yet there have been remarkably few systematic, longitudinal investigations of FCR and its health consequences. A long-term objective of the proposed work is to influence the development and refinement of interventions for FCR and health behaviors (i.e., physical activity/sedentary behavior, medication adherence, and sleep), ultimately improving mental and physical well- being of cancer survivors and their spouses/partners. The focus of this proposal echoes the recent Cancer MoonshotSM Blue Ribbon Panel report (Recommendation F: Symptom Management Research) that future research improve symptom monitoring and management with the long-term goal of supporting completion of cancer treatment and reducing cancer recurrence.

PI_NAMEs: LAURENCEAU, JEAN-PHILIPPE  (contact)

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: Adherence;Adjuvant;Adjuvant Therapy;Biological Markers;Body Composition;Breast Cancer survivor;cancer diagnosis;Cancer Etiology;cancer recurrence;Cancer Survivor;cancer therapy;cardiometabolism;Cardiovascular Diseases;Cross-Sectional Studies;Data;Development;Diagnosis;diaries;Equation;Fasting;Fright;Funding;Glycosylated hemoglobin A;Goals;Health;Health behavior;Health behavior and outcomes;Hormonal;improved;indexing;Individual;innovation;Insulin Resistance;intervention refinement;Investigation;Knowledge;Link;Lipids;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;medication compliance;Metabolic Diseases;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;Outcome;Parameter Estimation;Patient Self-Report;Patients;Personal Satisfaction;Persons;Physical activity;Population;power analysis;Prevalence;Psyche structure;Public Health;Publishing;Quality of life;Recommendation;Recurrence;Reporting;Research;Risk;screening;sedentary lifestyle;Sleep;Sleep disturbances;sleep quality;sleep quantity;Spouses;Strenuous Exercise;symptom management;symptomatic improvement;Time;treatment adherence;Treatment/Psychosocial Effects;Weight Gain;Women's mortality;Work

PROJECT_TITLE: Health Consequences of Fear of Cancer Recurrence in Breast Cancer Survivors and Partners

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Project Narrative Metabolic reprogramming in non-small cell lung cancer (NSCLC) is well recognized to support cancer cell growth and proliferation, as well as to resist targeted therapy. The Shaw lab recently demonstrated that key metabolic regulator AMP-activated protein kinase (AMPK) is required for NSCLC tumor growth. While studies have shown AMPK signaling provides cancer cells with flexibility to adapt to metabolic stresses, this proposed study will examine epigenetic mechanisms by which AMPK promotes metabolic reprogramming and lung tumor growth.

PI_NAMEs: YOMTOUBIAN, SHIRA  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: 5'-AMP-activated protein kinase;Address;Alanine;Binding;Bioinformatics;Biological Assay;bisulfite sequencing;cancer cell;Cancer Cell Growth;Cancer cell line;Cancer Etiology;Cancer Patient;Cell Physiology;Cell Proliferation;Cell Respiration;Cells;Characteristics;Consensus;DNA Methylation;DNA Methylation Regulation;DNA Modification Methylases;DNMT3a;Epigenetic Process;epigenome;Exhibits;Face;flexibility;Generations;Genetic;Genus Hippocampus;Growth;Homologous Gene;Impairment;improved;In Vitro;in vivo;insight;Invaded;Knock-in;Knock-out;KRASG12D;Lesion;lung cancer cell;lung colonization;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Metabolic;Metabolic stress;Metabolism;Methylation;methylation pattern;Methyltransferase;migration;Mitochondria;Modeling;mortality;mouse model;Mus;mutant;Mutation;Neoplasm Metastasis;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;Oncogenic;Pathway interactions;Patients;Phenotype;Phospho-Specific Antibodies;Phosphorylation;programs;Proliferating;Proteins;Rattus;Refractory;Regulation;Reporting;Role;Sarcoma;sensor;Serine;Signal Pathway;Signal Transduction;targeted treatment;Testing;therapeutic target;therapeutically effective;Time;transcriptome sequencing;tumor;Tumor Burden;tumor growth;tumor initiation;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;tumorigenic;Tumorigenicity;Validation;Viral Oncogene;whole genome;Work

PROJECT_TITLE: Decoding AMPK-dependent regulation of DNA methylation in lung cancer


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;HIV/AIDS;Heart Disease;Infectious Diseases;Nutrition;Physical Activity

PHR: Nearly one-half of people living with HIV (PLWH) today have left ventricular diastolic dysfunction (DD), which is associated with the progression to heart failure with preserved ejection fraction (HFpEF) but the causes of DD and its progression in PLWH are poorly understood. Our preliminary studies suggest that impaired cardiac energy metabolism may be a critical factor for DD in PLWH and thus we propose to examine, in cross -sectional and longitudinal studies, cardiac metabolism in PLWH using sophisticated non-invasive 31P MRI/MRS technologies, reasons for impairment including cardiac lipid accumulation, systemic inflammation, and insulin resistance, and its relationship with echocardiographic and other indices of DD and cardiovascular performance. The results will provide novel insights into the pathophysiology of DD in PLWH and inform the selection of preventive and therapeutic interventions to decrease the burden and consequences of DD in PLWH. `

PI_NAMEs: WEISS, ROBERT G (contact)

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: Acceleration;Activities of Daily Living;Age;ATP Synthesis Pathway;Atrial Fibrillation;Biological Markers;Body mass index;Cardiac;cardiometabolism;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;Chronic;Chronic Disease;Clinical;Clinical Research;cohort;coronary fibrosis;Creatine Kinase;Data;design;Development;Diastolic blood pressure;Diastolic heart failure;Disease;Echocardiography;effective therapy;EFRAC;Energy Metabolism;Ethnic Origin;Exercise;exercise intolerance;Exercise Tolerance;experience;factor A;Fibrosis;Frequencies;functional decline;Functional disorder;Future;General Population;Glucose Intolerance;Heart;Heart Diseases;Heart failure;heart metabolism;HIV;HIV Infections;Hypertension;immune activation;Impairment;improved;in vivo;Incidence;indexing;Individual;Inflammation;inhibitor;inorganic phosphate;insight;Insulin Resistance;Left;Left Ventricular Dysfunction;Link;Lipids;Longitudinal Studies;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;Mechanics;Medicine;men;Metabolic;Metabolism;middle age;Mitochondria;Modeling;mortality;Muscle;Muscle Mitochondria;Myocardial;Myocardium;Myopathy;novel;Outcome;Patients;Performance;Persons;Pilot Projects;Population;pre-clinical;preservation;Prevalence;preventive intervention;prospective;Public Health;Questionnaires;Race;randomized trial;Reaction;Recording of previous events;Relaxation;Reporting;Research Personnel;Resources;Rest;Risk Factors;Severities;sex;Skeletal Muscle;Symptoms;systemic inflammatory response;Techniques;Technology;Testing;Therapeutic Intervention;Time;Tissues;United States National Institutes of Health;Ventricular;Viral;Viremia;Walking;Woman

PROJECT_TITLE: Cardiac Energy Metabolism and Diastolic Dysfunction in PLWH

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-T(90)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Hematology;Mental Health;Mental Illness;Pain Research;Prevention;Rare Diseases;Sleep Research

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative Chronic hematological cancer (CHC) patients are characterized by long term and high symptom burden, including up to 65% reporting chronic sleep disturbances that are also often associated with inflammation, fatigue, and emotional distress (anxiety and depression). Meditation is an effective non-pharmacologic strategy to self-manage and improve cancer-related symptoms and mediation delivered via mobile applications may address cancer patients’ barriers to in-person interventions (i.e., fatigue, pain, transportation, scheduling difficulties) without the time and expertise limitations of cognitive behavioral therapy for insomnia (CBT-I) and side effect risks from medication. This study is the first to test a commercially available, smartphone-based meditation application to self-manage sleep disturbance, inflammation fatigue, and emotional distress (anxiety, depression), among CHC patients and to explore the sustained effects of meditation compared to a health education podcast control group.

PI_NAMEs: HUBERTY, JENNIFER LYNNE (contact);MESA, RUBEN A.

PROGRAM_OFFICER_NAME: PERLOFF, MARJORIE

PROJECT_TERMS: actigraphy;active control;Address;Aftercare;Age;Anxiety;Attention;Behavioral;Biological;Biological Markers;Blood;Blood specimen;Breast Cancer Patient;cancer care;cancer diagnosis;Cancer Patient;cancer subtypes;care providers;Cellular Phone;Chronic;Clinical;Cognitive;cognitive function;Cognitive Therapy;comparison control;Consumption;Control Groups;Data;Dependence;depressive symptoms;Diagnosis;diaries;Disease;Distress;Dose;Double-Blind Method;Dysmyelopoietic Syndromes;effectiveness evaluation;efficacy testing;emotional distress;empowerment;Ethnic Origin;Evidence based treatment;experience;falls;Fatigue;follow-up;Gender;Health education;health management;Hematologic Neoplasms;IL8 gene;improved;improved outcome;indexing;industry partner;Inflammation;inflammatory marker;innovation;interest;Interleukin-6;Intervention;Knowledge;Lead;leukemia;Lymph;Lymphoma;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Measures;Mediation;Meditation;Mental Depression;Methods;Middle Insomnia;mindfulness intervention;mobile application;Multiple Myeloma;Myelodysplastic/Myeloproliferative Disease;Myeloproliferative disease;Nonpharmacologic Therapy;novel;older adult;Outcome;Pain;Participant;Patient Recruitments;Patient Self-Report;patient-level barriers;Patients;persistent symptom;Persons;Pharmaceutical Preparations;pharmacologic;Physical Function;Pittsburgh Sleep Quality Index;Placebos;podcast;post intervention;primary outcome;psychologic;Quality of life;Race;Randomized;Reporting;Research;Residual Neoplasm;Resources;Risk;Schedule;secondary outcome;Self Management;Severities;side effect;Sleep;Sleep Disorders;Sleep disturbances;Sleeplessness;smartphone application;Solid Neoplasm;Survivors;survivorship;Symptom Burden;Symptoms;Testing;Time;TNF gene;Transportation;uptake;Work

PROJECT_TITLE: Consumer-based meditation app, Calm, for treatment of sleep disturbance in hematological cancer patients

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Human Genome;Orphan Drug;Prevention;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: Project Narrative Fanconi anemia is the most common inherited cause of low blood counts and 90% of patients will be affected by the age of 40. While deficient repair of DNA damage is the hallmark of Fanconi anemia, there is no available therapy that prevents DNA damage from happening. Our study may identify new targets that may be used to prevent DNA damage and low blood counts in patients with Fanconi anemia and in the general population.

PI_NAMEs: JUNG, MOONJUNG  (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Acceleration;Acetaldehyde;Acute Myelocytic Leukemia;acute T-cell lymphoblastic leukemia cell;Affect;Age;aldehyde dehydrogenases;Aldehydes;Allogenic;Attention;Award;Biological Assay;Blood;Bone Marrow;Bone marrow failure;bone marrow failure syndrome;Cell Death;Cell Line;Cell Separation;cell transformation;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;CRISPR/Cas technology;crosslink;Defect;Disease Progression;DNA Adducts;DNA Damage;DNA Interstrand Cross-Link Repair;DNA Interstrand Crosslinking;DNA Repair;DNA Repair Disorder;Drug Metabolic Detoxication;Dysmyelopoietic Syndromes;Engraftment;Enzymes;experience;FANCD2 protein;Fanconi Anemia pathway;Fanconi anemia protein;Fanconi's Anemia;fitness;Formaldehyde;Frequencies;Functional disorder;Gene Modified;General Population;Genes;Genetic;genetic information;Genome;genome integrity;Genomic Instability;Goals;graft vs host disease;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;hematopoietic tissue;Human;Impairment;In Vitro;in vivo;Inherited;Inherited bone marrow failure;Knock-out;Knowledge;Lesion;liquid chromatography mass spectrometry;Maintenance;Metabolic;Modernization;Monitor;mortality;mouse model;Mus;new therapeutic target;next generation sequencing;novel;novel therapeutics;Pathogenesis;Pathway interactions;Patients;Physicians;Population;prevent;Prevention;protective pathway;repaired;Reporting;Research;Ribonucleoproteins;Risk;Role;Scientist;screening;Screening Result;skill acquisition;Solid Neoplasm;Source;synthetic lethal interaction;Testing;therapeutic target;Training;Transplantation;Validation;Variant;Work

PROJECT_TITLE: Novel sources of endogenous DNA damage in hematopoietic stem progenitor cells


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Nutrition;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE This project is tightly aligned with the NIH mission by unveiling new epigenetic mechanisms that account for the embryonic heart development, with a focus on the DNA methylation homeostasis and maternal metabolic influence. Our studies will furnish important insights that are immediately relevant to the precise temporal and spatial epigenetic regulation which contributes to the normal heart development. Our discoveries will significantly promote healthy cardiac development and illuminate previously underappreciated epigenetic mechanisms underpinning congenital cardiovascular diseases and cardiovascular diseases.

PI_NAMEs: HUANG, YUN  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Address;Ascorbic Acid;Cardiac;cardiogenesis;Cardiovascular Diseases;Chromatin;Congenital Cardiovascular Abnormality;congenital heart abnormality;Defect;Development;Developmental Process;Dioxygenases;DNA Methylation;Embryonic Heart;embryonic stem cell;Enhancers;Epigenetic Process;epigenetic regulation;Exhibits;Family;Gene Expression;Gene Modified;Genetic Transcription;Heart;High Fat Diet;Homeostasis;human embryonic stem cell;Impairment;insight;lipid metabolism;Mediating;Metabolic;Mission;Molecular;mouse model;Mutation;Non-compaction cardiomyopathy;oxidation;Pathogenicity;Pathway interactions;Patients;Play;prenatal;progenitor;programs;promoter;Proteins;Regulation;Research;Risk Reduction;Role;Specific qualifier value;Specificity;stem cell differentiation;stressor;Testing;Tetanus Helper Peptide;Tissues;United States National Institutes of Health

PROJECT_TITLE: Epigenetic regulation in cardiac development


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Neurosciences;Substance Misuse

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative Large-scale DNA and RNA sequencing, bioinformatics, and computational approaches have greatly advanced addiction neurobiology. Our studies will be the first to use cell-type-specific RNA sequencing to define the brain transcriptome from human alcoholics and alcohol-dependent mice in unprecedented detail. Our overarching hypothesis is that conserved cell-type-induced transcriptome changes will reveal specific neurobiological mechanisms and improved drug targets for excessive alcohol drinking.

PI_NAMEs: MAYFIELD, R. DAYNE (contact)

PROGRAM_OFFICER_NAME: GITIK, MIRI

PROJECT_TERMS: addiction;Adult;Alcohol abuse;alcohol behavior;Alcohol consumption;Alcohol dependence;Alcohols;Animal Model;Animals;Astrocytes;Behavioral;Bioinformatics;Brain;brain cell;Breeding;Candidate Disease Gene;Cell Nucleus;cell type;Cells;Chronic;Consumption;Data;data integration;Data Set;Dependence;differential expression;DNA sequencing;drinking;drug efficacy;Drug Targeting;drug testing;Ethanol;Freezing;Funding;gene conservation;Gene Expression;Gene Expression Profile;Gene Targeting;Genes;Genetic;Genetic Transcription;Heavy Drinking;Human;human data;improved;in vivo evaluation;Individual;Mechanics;Microglia;Modeling;Molecular Target;mouse model;Mus;neuroadaptation;neurobiological mechanism;Neurobiology;new therapeutic target;Pathway interactions;Pharmaceutical Preparations;Physical Dependence;Prefrontal Cortex;prevent;problem drinker;Research;Resistance;Resolution;single cell sequencing;single nucleus RNA-sequencing;single-cell RNA sequencing;Systems Biology;targeted treatment;Technology;Testing;therapeutic target;Tissues;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;Validation;vapor;Withdrawal

PROJECT_TITLE: Gene Expression in the Human Alcoholic Brain

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative To support the development of novel anti-cancer therapies, we propose continuation of a multidisciplinary, institution-wide cancer biology T32 postdoctoral training program at City of Hope (Duarte, CA) to prepare exceptionally motivated postdoctoral fellows in the fields of DNA damage response and oncogenic signaling (DNADRS). Because cancer disproportionately impacts minority populations in the US, we have implemented a strategy, which is aided by exceptional institutional support for salaries and research funds, to emphasize attracting and training scientists from underrepresented minority (URM) backgrounds. With our collection of outstanding DNADRS researchers and physician collaborators, state of the art facilities, strong curriculum, emphasis on obtaining extramural funding, superb institutional support, and the last 5 year’s successful experience, we request the continued support to DNADRS T32 program, which will train the next generation of leaders in the fight against cancer.

PI_NAMEs: SHEN, BINGHUI ;STARK, JEREMY MICHAEL (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TITLE: DNA Damage Response and Oncogenic Signaling

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Positron emission tomography (PET) is the premier imaging modality for diagnosis and/or guiding treatment of diseases such as cancer and neurological disorders through its ability to visualize and quantify the distribution of radionuclide-labeled biological probe molecules. Current PET systems are unable to image multiple tracers in one session, however we hypothesize that visualizing and quantifying multiple biomarkers in the same imaging session will lead to more accurate diagnosis and effective guidance in treatment decisions. This project will enable simultaneous multi-tracer PET through addition of an endcap detector and signal processing techniques to increase detection efficiency, increase quantitative accuracy of measuring the activity of multiple radiotracers in the same imaging session, and reduce the amount of systematic error in the ‘multiplexed PET study’ due to random or misclassified events.

PI_NAMEs: FOSTER, JACKSON WEST (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;Algorithms;Alzheimer's Disease;Amyloid beta-Protein;Biological;Biological Markers;Biological Process;Biology;Compensation;Computational algorithm;Consumption;Data;deep learning;design and construction;Detection;detection platform;detector;Diagnosis;Disease;DNA;Dose;Electrons;Elements;Event;Gamma Rays;Geometry;glucose uptake;Image;imaging modality;improved;in vivo;innovation;Joints;Label;Malignant Neoplasms;Maximum Likelihood Estimate;Measures;Medical Imaging;Methods;Molecular;Nerve Degeneration;Nervous System Disorder;neuroinflammation;Pathway interactions;Patients;photon-counting detector;Photons;Positioning Attribute;Positron;Positron-Emission Tomography;potential biomarker;Probability;Proliferating;Radioisotopes;radiotracer;receptor density;response;Scanning;signal processing;Solid;statistics;System;tau Proteins;Techniques;Testing;Time;Tissues;Tracer;two-photon;Visualization

PROJECT_TITLE: Simultaneous Multi-Tracer Positron Emission Tomography for Interrogating Molecular Pathways of Neurological Disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-P(20)L]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Regenerative Medicine;Wound Healing and Care

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Project Narrative Corneal blindness affects more than 12.5 million people, yet less than 2% of patients worldwide have access to the human donor tissue needed for its conventional treatment. To address this major global health need, my work seeks to develop a 3D bioprinting strategy for precise spatial patterning of bioinks composed of collagen and human corneal mesenchymal stromal cells to study and leverage the effects of their microenvironment on their regenerative potential. This interdisciplinary approach will recapitulate the unique structural, optical, and biological features of the human cornea toward the goal of restoring vision on-demand with bioengineered tissue.

PI_NAMEs: BRUNEL, LUCIA  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: 3-Dimensional;Address;Affect;Alkynes;Animals;Autologous;Azides;Behavior;beneficiary;Biocompatible Materials;bioink;Biological;Biomedical Engineering;Biophysics;bioprinting;Blindness;Cadaver;catalyst;Cell secretion;Cell Therapy;Cells;Chemistry;Cicatrix;Clinical Markers;clinical translation;Collaborations;Collagen;Collagen Fibril;Collagen Type I;Complex;Computer-Aided Design;Contracts;conventional therapy;Cornea;Corneal Diseases;corneal epithelial wound healing;Corneal Injury;corneal regeneration;corneal scar;Corneal Stroma;corneal surgery;cross reactivity;crosslink;Cues;curative treatments;Custom;cycloaddition;Defect;Deposition;design;Development;Doctor of Medicine;Doctor of Philosophy;Educational workshop;empowerment;Encapsulated;Engineering;Epithelium;Exhibits;Eye;Eye diseases;Fostering;Foundations;Friends;Future;Geometry;global health;Goals;Harvest;healing;Human;Hydrogels;Immune response;immunohistochemical markers;Implant;implantation;improved;improved outcome;in vivo;Inflammation;Inflammatory Response;Ink;innovation;interdisciplinary approach;Keratoplasty;Laboratories;Light;materials science;mechanical properties;Mentorship;mesenchymal stromal cell;Methods;Modeling;Monitor;Natural regeneration;Ophthalmology;Optics;Oryctolagus cuniculus;Paracrine Communication;Patient-Focused Outcomes;Patients;Pattern;Persons;Phenotype;Physicians;pre-clinical;prevent;Process;Production;Productivity;Property;Proteins;re-epithelialization;Reaction;regeneration potential;regenerative;Regenerative capacity;regenerative cell;Regenerative Medicine;Regenerative response;Research;Research Ethics;Research Proposals;response;restoration;Scientist;Series;sight restoration;skills;Source;Structure;Surface;symposium;System;Technical Expertise;Techniques;Testing;Therapeutic;Thick;Time;Tissue Donors;Tissue Engineering;Tissue Grafts;Tissues;Training;translational applications;translational potential;Transplantation;Visual impairment;Work;Wound models;Writing

PROJECT_TITLE: 3D bioprinting of regenerative, corneal cell-laden inks to treat corneal blindness


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Huntington's disease is a fatal neurodegenerative condition caused by a genetic defect that worsens over time as a result of faulty DNA mismatch repair. This proposal seeks to use small RNA drugs to modulate key mediators of mismatch repair in a mouse model of Huntington's disease, and determine the impact on blocking or reversing the gene defect and reducing disease progression. Findings from this study will inform the rational design of therapeutics for Huntington's disease and other neurological disorders associated with faulty mismatch repair.

PI_NAMEs: BELGRAD, JILLIAN  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Adverse effects;Antisense Oligonucleotides;autosome;Bacterial Artificial Chromosomes;Binding;Binding Proteins;Bioinformatics;Biological Assay;CAG repeat;Cells;Chemistry;Clinical;clinically relevant;Complex;Corpus striatum structure;curative treatments;Defect;design;Disease;disease model;Disease Outcome;disease phenotype;Disease Progression;DNA;DNA-Protein Interaction;early onset;efficacy validation;endonuclease;Event;Exons;Fibroblasts;Frequencies;Gait;gene repair;Genes;Genetic;Genetic Polymorphism;Genetic Transcription;Hand Strength;Harvest;Histology;Human;Huntington Disease;Huntington gene;Immunohistochemistry;Impaired cognition;improved;in vivo;in vivo Model;Inherited;Injections;Interphase Cell;Knock-out;Lead;Length;Link;Measures;Mediating;Mediator;Mental Depression;Messenger RNA;Mismatch Repair;MLH1 gene;Motor;motor behavior;motor disorder;mouse model;MSH2 gene;MSH3 gene;Mus;mutant;Mutation;Nerve Degeneration;Nervous System Disorder;Neurobiology;Neurodegenerative Disorders;Neurons;novel;nuclease;nucleic acid binding protein;Nucleotides;Oligonucleotides;Onset of illness;Pathogenicity;Pathology;Patients;Pharmaceutical Preparations;PMS1 gene;PMS2 gene;pre-clinical;prevent;Process;Proteins;Radiology Specialty;rational design;recruit;Repair Complex;repair enzyme;Severities;Severity of illness;Small Interfering RNA;Small RNA;success;Symptoms;System;Therapeutic;therapeutic development;therapy design;Time;Training;transcriptome sequencing;Trinucleotide Repeat Expansion;Ventricular;Walking;Work

PROJECT_TITLE: Modulation of Somatic Repeat Expansion as a Therapeutic Approach to Huntington's Disease


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: IOWA CITY

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative In the United States, one in 44 children is diagnosed with autism spectrum disorder (ASD), the symptoms of which can sometimes lead to significant disability and stress for affected individuals. Enlargement of the dorsal striatum may contribute to patterns of restrictive, repetitive behavior, a core feature of the condition and the developmental regulation of which is not understood. Cellular and molecular investigations of striatal enlargement will lead to better understanding of the role of striatal abnormalities within neurodevelopmental disorders including ASD, as well as new methods of prevention and therapeutic treatment.

PI_NAMEs: EVANS, MAYA  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Adult Children;Affect;Agonist;autism spectrum disorder;autism symptoms;autistic children;Automation;Basal Ganglia;Behavior;Behavioral;behavioral outcome;Biological;Brain;Cell Proliferation;Cells;Child;Corpus striatum structure;Data;density;design;Development;Diagnosis;diagnostic criteria;disability;Disease;Dorsal;Embryo;Embryonic Structures;Environmental Risk Factor;Exhibits;experimental study;Functional disorder;Future;Gene Expression;Genes;Growth;habit learning;Habits;Immunohistochemistry;in utero;Individual;Injections;interest;Investigation;Laboratories;Lateral;Lead;learned behavior;Learning;Link;Measures;Mental disorders;Metabotropic Glutamate Receptors;Methods;Modeling;Molecular;Motor Activity;motor behavior;mouse model;Mus;Neurobiology;Neurodevelopmental Disorder;Neurodevelopmental Impairment;Neurons;offspring;Pathway interactions;Pattern;Play;Pregnancy;prenatal;prenatal stress;prevent;Prevention;Process;Proliferating;Regulation;repetitive behavior;Risk;risk mitigation;Role;sample fixation;Scheme;single-cell RNA sequencing;Stereotyped Behavior;Stress;Structure;Testing;Therapeutic;therapy design;time interval;United States

PROJECT_TITLE: Cellular and molecular investigations of striatal enlargement in prenatal stress model of neurodevelopmental risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F01A-V(20)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Nicotinamide N-methyltransferase (NNMT), a key enzyme in the NAD+ salvage pathway with unclear functions, is expressed highly and specifically in basal-like breast cancer (BLBC). We propose that NNMT, which is regulated by the FOXC1-CARM1 complex, is a critical gatekeeper to promote tumor progression, metastasis and drug-resistance in BLBC. Our systematic and complementary analyses will lead to a major advance in the understanding of breast cancer biology and the development of novel therapeutic strategies for metastatic BLBC.

PI_NAMEs: ZHOU, BINHUA P (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Acetylation;Aging;Anchorage-Independent Growth;Animal Model;Apoptotic;arginine methyltransferase;Brain;Breast Cancer Cell;breast cancer metastasis;breast cancer progression;Cancer Biology;Cancer Cell Growth;Cell model;Cell Nucleus;Clinical;coactivator-associated arginine methyltransferase 1;Code;Complex;CRISPR library;Cytoplasm;Data;Development;Diabetes Mellitus;Diagnosis;Disease;Drug resistance;druggable target;Endowment;Environment;Enzymes;Event;Exhibits;experimental study;extracellular;Extravasation;Family;FOXC1 gene;Gatekeeping;Genetic Transcription;Goals;Homeostasis;Human;In Vitro;in vivo;inhibitor;innovation;knock-down;Knock-out;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;mammary gland development;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methyltransferase;Mitochondria;mouse model;multidisciplinary;NADH;NADP;Neoplasm Metastasis;Niacinamide;Nicotinamide adenine dinucleotide;Nicotinamide N-Methyltransferase;novel therapeutic intervention;Oncogenic;Oxidation-Reduction;oxidative damage;Oxidative Stress;Pathologist;Pathway interactions;patient derived xenograft model;Pharmaceutical Preparations;Pharmacotherapy;Positioning Attribute;prevent;Prognosis;Prognostic Marker;Proliferating;Property;Reactive Oxygen Species;Regimen;Regulation;Rejuvenation;Research;Respiration;Rodent;Role;screening;Shapes;Signal Pathway;Site;Specimen;stemness;success;Suspensions;synergism;Talents;Testing;Therapeutic;therapeutically effective;therapy resistant;transcription factor;Transcriptional Regulation;tumor growth;tumor progression;Tumor Promotion;Up-Regulation;uptake;Vertebral column;Xenograft Model

PROJECT_TITLE: Defining the Critical Function and Regulation of NNMT in Breast Cancer Progression and Metastasis

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Activation of bacterial cell wall synthesis proteins provide the driving force for cell division. How these proteins are dynamically activated in cells is unknown. Here we track single molecules in live cells to determine how these proteins are activated, in hopes of providing us with greater insights on how to battle antibiotic resistant bacteria.

PI_NAMEs: PEREZ, AMILCAR JOSUE (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: analysis pipeline;Back;Bacterial Antibiotic Resistance;Cell division;Cell Shape;Cell Wall;Cells;Complex;constriction;crosslink;Cytolysis;Cytoprotection;Cytoskeletal Proteins;daughter cell;driving force;dynamic system;enzyme activity;Enzyme Kinetics;Enzymes;Equilibrium;Escherichia coli;Exhibits;Frequencies;Future;Genetic;genetic variant;Geometry;Glucosyltransferase;glycosyltransferase;Goals;Growth;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Homologous Gene;Hydrolase;Hydrolysis;imaging study;Immobilization;Individual;insight;Kinetics;Knowledge;Light;Lighting;Lipids;Measurement;Measures;Microscopy;Molecular;molecular imaging;Morphogenesis;Morphology;Motion;Movement;Multienzyme Complexes;novel;Osmosis;Outcome;Pathway interactions;Peptidoglycan;Peptidyltransferase;Polymers;Population;Process;Protein Biosynthesis;Protein Dynamics;protein phosphatase inhibitor-2;protein protein interaction;Proteins;recruit;Regulation;Regulatory Pathway;Role;Scanning Electron Microscopy;Scheme;Shapes;Signal Transduction;single molecule;spatiotemporal;Stress;Structure;Time;tool;treadmill;Tubulin;Variant;Work;z-ring

PROJECT_TITLE: Elucidating the spatiotemporal regulation of septal peptidoglycan synthases in E.coli

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cardiovascular;Clinical Research;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

PHR: Project Narrative The overarching goal of this project is to determine if dysfunction of the autonomic nervous system (ANS) is one of the earliest pathological features of Huntington's Disease (HD). To accomplish this goal, I will 1) quantitatively characterize functional and structural changes in brain areas that control the ANS and 2) investigate physiologic measures of ANS dysfunction in children who carry the gene expansion that causes HD. The proposed research aims to explore novel pathological mechanisms that underlie the progression of HD in order to improve therapeutic strategies.

PI_NAMEs: SCHULTZ, JORDAN  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: 18 year old;Adrenergic beta-Antagonists;Adult;Age;Age of Onset;aged;Anterior;Aorta;Area;arterial spin labeling;arterial stiffness;Atrophic;Autonomic Dysfunction;Autonomic nervous system;Baroreflex;beta-adrenergic receptor;Biometry;blood oxygen level dependent;Blood Pressure;Body Temperature;Brain;Brain region;Cardiovascular system;career;career development;Carotid Arteries;Cerebrovascular Circulation;Cerebrovascular system;Child;Chronic;cingulate cortex;comparison control;Complication;Corpus striatum structure;Disease;Disease Progression;Ensure;Equilibrium;Etiology;Exhibits;experience;experimental study;Family;Functional disorder;Functional Magnetic Resonance Imaging;Funding;gene therapy;Gene therapy trial;Genes;Goals;Grant;Heart Rate;heart rate variability;Homeostasis;Huntington Disease;Huntington gene;Hypertension;improved;Insula of Reil;Iowa;K-Series Research Career Programs;Location;Magnetic Resonance Imaging;Measures;Mentors;Mentorship;Methods;Modification;Motor;mutant;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Nervous System Physiology;Neurobiology;Neurodegenerative Disorders;neurodevelopment;neurofilament protein L;neuroimaging;new therapeutic target;novel;novel therapeutics;Outcome;Participant;Pathologic;patient oriented;patient population;Patient Recruitments;Patients;Pharmaceutical Preparations;Pharmacists;pharmacologic;Physiological;Plasma;Positioning Attribute;Prefrontal Cortex;prevent;Principal Investigator;Publishing;Recording of previous events;Reporting;Research;Research Personnel;Rest;Risk;Sampling;Signal Transduction;Structure;success;Sympathetic Nerve Block;Sympathetic Nervous System;Symptoms;Testing;Therapeutic;therapeutic biomarker;therapeutic target;Thinness;Time;Training;Training Programs;translational scientist;Trinucleotide Repeats;Vascular System

PROJECT_TITLE: Investigating Autonomic Dysfunction as an Early Pathologic Feature of Huntington’s Disease

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Cerebrovascular;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Neurovascular coupling (NVC) is a crucial mechanism that translates neural activity into local cerebral blood flow changes. This study aims to investigate whether the endogenous activity of Tacr1 neurons, a unique type of cortical inhibitory neurons that mediate NVC, is regulated by substance P across different brain states. A better understanding of the mechanisms mediating NVC may provide critical knowledge for understanding blood- oxygen-level-dependent (BOLD) signal and for identifying cerebrovascular targets for future therapeutic treatments.

PI_NAMEs: JUAREZ ANAYA, MARIA FERNANDA  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: antagonist;awake;blood oxygen level dependent;Brain;brain health;Brain imaging;brain tissue;Calcium;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Complex;Development;Disease;Electroencephalography;Ensure;Enzymes;experimental study;Fellowship;Frequencies;Functional Magnetic Resonance Imaging;Future;G-Protein-Coupled Receptors;Goals;Health;hemodynamics;Human;Image;imaging study;in vivo;inhibitory neuron;Knowledge;Laser-Doppler Flowmetry;leadership development;Ligands;Link;Measures;Mediating;Mediator;Mentors;Microscopy;Molecular;Mus;Nervous System Disorder;neural;Neurons;Neuropeptides;neurovascular;neurovascular coupling;neurovascular unit;Nitric Oxide;Nitric Oxide Synthase Type I;Nitric Oxide Synthetase Inhibitor;Nutrient;optogenetics;Oxygen;Parvalbumins;Pathway interactions;Perfusion;Process;Production;Research Personnel;Research Training;response;Risk;Scientist;Signal Transduction;Sleep;Somatosensory Cortex;Source;Stroke;Substance P;TAC1 gene;TACR1 gene;Testing;Therapeutic;Tissues;Training;training opportunity;Translating;two-photon;Vasodilation;Vasodilator Agents;Viral;Wakefulness

PROJECT_TITLE: Investigating the mechanism by which Tacr1 Neurons Regulate Neurovascular Coupling


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

ORG_CITY: MILWAUKEE

ORG_DEPT: SURGERY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Public Health Relevance These investigations focus on uncovering a window of opportunity to provide novel targets and treatment approaches for pancreatic cancer, a painful and deadly disease. Our approach seeks to understand the intersection of normal processes required to duplicate the genome and how they then tolerate rapid division of cancer with the goal of using this knowledge to find targetable vulnerabilities. Thus, the studies in this grant proposal align with NCI’s mission to advance scientific knowledge and help all people live longer, healthier lives with our ultimate goal to advance toward informed and improved therapeutic strategies for pancreatic cancer patients.

PI_NAMEs: LOMBERK, GWEN  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Adenocarcinoma Cell;Applications Grants;Area;Bypass;cancer cell;cancer initiation;Cell Aging;Cell Cycle;Cell Cycle Stage;Cell Death;cell growth;Cells;CHEK1 gene;Chromatin Structure;Combined Modality Therapy;Compensation;Complex;coping;Data;Data Reporting;Development;Disease;DNA biosynthesis;DNA Damage;DNA damage checkpoint;DNA replication fork;Epigenetic Process;epigenome;epigenomics;Event;Functional disorder;Future;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;Genomic DNA;Genomics;Germ-Line Mutation;Goals;Growth;histone methyltransferase;improved;In Vitro;in vivo;individual patient;inhibitor;inhibitor therapy;insight;Interphase;Investigation;Knowledge;KRAS2 gene;Licensing;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mission;Molecular;novel;novel therapeutics;Oncogenes;Outcomes Research;Pain;Pancreatic Adenocarcinoma;pancreatic cancer patients;Pancreatic Intraepithelial Neoplasia;Pathway interactions;patient subsets;Patients;Persons;Pharmaceutical Preparations;Predisposition;prevent;Process;Proliferating;Proteins;public health relevance;repaired;replication stress;research clinical testing;response;Role;S phase;Scientific Advances and Accomplishments;Signal Induction;Signal Transduction;stress tolerance;synergism;Testing;Therapeutic;Therapeutic Effect;therapy development;treatment strategy;tumor;tumor progression;tumorigenesis;whole genome

PROJECT_TITLE: Targeting Epigenomic Regulators at the Replication Fork in PDAC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Obesity

ORG_CITY: BIRMINGHAM

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Obesity afflicts millions of American adults and children and is a problem of enormous public health relevance as it exerts a heavy burden on patient suffering and social costs. Its causes remain incompletely understood and, while available treatment and prevention approaches are improving, there is much room for improvement. We will train postdoctoral fellows and position them for independent research careers as they evolve to be our future scientific leaders in obesity, and will provide summer research fellowships to medical students to nurture interests in careers as future physician scientists.

PI_NAMEs: GARVEY, W TIMOTHY (contact);HILL, JAMES O

PROGRAM_OFFICER_NAME: KAMARA, FANTA

PROJECT_TERMS: Obesity;Training Programs

PROJECT_TITLE: UAB Obesity Training Program

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]