NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Complementary and Integrative Health;Dementia;Dietary Supplements;Genetics;Natural Products;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Epidemiological data suggest that greater adherence to the Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) slows the rate of cognitive decline and reduces the risk of Alzheimer's disease (AD).The current proposal leverages the first, ongoing MIND trial as well as existing community- and population-based data to examine how genetic differences in (a) AD predisposition and (b) nutrient metabolism modify the response to the MIND diet. Our research will provide mechanistic insights into the role that MIND may play in slowing cognitive decline and will also inform the implementation of MIND for optimal effectiveness.

PI_NAMEs: CORNELIS, MARILYN C (contact)

PROGRAM_OFFICER_NAME: FENG, LI REBEKAH

PROJECT_TERMS: Adherence;Affect;Age Years;Age-associated memory impairment;Aging;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Animals;Autopsy;bean;Berry;Biological;Brain;Brain-Derived Neurotrophic Factor;Carotenoids;Characteristics;Cholesterol;Cholesterol Homeostasis;circulating biomarkers;Clinical;Cognitive;cognitive change;Communities;Complex;Consumption;DASH diet;Data;Dementia;Diet;Dietary Fiber;Dietary Intervention;Dietary Practices;Disease;Disease susceptibility;Domestic Fowls;Effectiveness;Environmental Risk Factor;epidemiologic data;Epidemiology;Folic Acid;folic acid metabolism;Food;Genes;Genetic;genetic information;genome wide association study;Genotype;glucose metabolism;Health;human old age (65+);Immune response;Immune Targeting;Immunity;Impaired cognition;Impairment;indexing;Individual;Inflammation;insight;Intake;Interleukin-6;Intervention;Knowledge;Literature;Magnetic Resonance Imaging;Maps;Measures;Mediating;men;Metabolism;mild cognitive impairment;Nerve Degeneration;neuropathology;Nutrient;nutrient metabolism;Nuts;Olive oil preparation;Participant;Pathologic;Pathway interactions;Patient Self-Report;Persons;Play;polyphenol;Population;population based;Predisposition;preventive intervention;Preventive measure;Probability;Prospective Studies;Research;response;Risk Reduction;Role;saturated fat;Seafood;Single Nucleotide Polymorphism;Single Nucleotide Polymorphism Map;Structure;Subgroup;Symptoms;tool;Unsaturated Fatty Acids;Variant;Vegetables;Vitamin E;Vitamin K;vitamin metabolism;Wine;Woman

PROJECT_TITLE: Genetic modifiers of the Mediterranean-DASH diet Intervention for Neurodegenerative Delay (MIND) response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-K(02)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Skin Cancer

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Mitochondria within cancer cells display heterogenic genomic compositions, functions, and network dynamics. However, the causes and consequences of mitochondrial heterogeneity on cancer development, prognosis, and treatment remain unknown. Therefore, it is important to investigate these pathways to understand how cancer occurs, and should be detected and treated.

PI_NAMEs: CHIPUK, JERRY EDWARD (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: Address;Antibodies;Biological Assay;Biology;Cancer Biology;cancer cell;Cancer Prognosis;cancer therapy;cancer type;Cell Death;Cell Death Induction;Cell Line;Cell Survival;Cells;Chronic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Data;Dermatology;Detection;Development;Disease;Event;FDA approved;Functional disorder;Generations;Genes;Genomics;Goals;Heterogeneity;Homeostasis;Human;improved;insight;Knowledge;Laboratories;Link;loss of function;Malignant - descriptor;Malignant Neoplasms;MAP Kinase Gene;melanocyte;Melanoma;Melanoma Cell;melanomagenesis;Metabolic;Metabolism;metabolomics;metaplastic cell transformation;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial dysfunction;Modeling;Molecular;Monoclonal Antibodies;Mus;Mutation;Nature;Neoplasm Metastasis;next generation;novel;Oncogenes;Oncogenic;Organelles;Pathogenesis;Pathway interactions;pharmacologic;Phenotype;prevent;Process;Prognosis;prognostic;prognostic assays;prognostic value;Proliferating;Publishing;Regulation;Resources;Risk;RNA Interference;Signal Transduction;small molecule;success;targeted treatment;Therapeutic;tool;tumor metabolism;tumorigenesis;tumorigenic;Work

PROJECT_TITLE: Chronic Mitochondrial Division and Melanoma: Mechanism, Prognosis, and Therapy

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ADMINISTERING_IC: HD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: Nashville

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE The placenta serves a myriad of critical functions in maintaining a healthy pregnancy, ranging from nutritional to immune to hormonal. However, currently, there are no practical tools that enable providers to monitor and incorporate placental development into clinical care. The current proposal leverages an ongoing collaboration between computer scientists, physician scientists and mathematicians to enable the use of modern fully automated image analysis methodology and mathematical modeling such that fetal-placental growth trajectories can be monitored and integrated into the clinical workflow.

PI_NAMEs: OGUZ, IPEK  (contact);SCHWARTZ, NADAV

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: 3D ultrasound;Acoustics;Algorithmic Analysis;antenatal;antenatal care;Area;Assessment tool;automated image analysis;automated segmentation;Award;Biological Markers;Biological Models;Blood;Blood Vessels;Characteristics;Clinical;clinical care;clinical predictors;Collaborations;computer scientist;deep learning algorithm;density;Detection;dynamic system;empowerment;Evaluation;fetal;Fetal Growth;Fetal Growth Retardation;Fetal Monitoring;Fetal Weight;Fetus;First Pregnancy Trimester;Gestational Age;Growth;Growth Disorders;Health;healthy pregnancy;histopathological examination;Histopathology;Hormonal;Human;Image;Image Analysis;Image Enhancement;image processing;Immune;improved;improved outcome;Individual;Infant;infant outcome;innovation;interdisciplinary approach;Knowledge;Late pregnancy;Laws;Link;Manuals;mathematical model;Measurement;Measures;Medical Imaging;Metabolic;Methodology;Methods;Modeling;Modernization;Monitor;Morphology;morphometry;National Institute of Child Health and Human Development;novel;novel strategies;Nutritional;open innovation;Outcome;Pathologic;Pathology;Pattern;Perinatal;Personal Satisfaction;personalized management;PGF gene;Physicians;Physics;Placenta;Placental Extracts;placental morphology;Placentation;Play;Postpartum Period;precision medicine;Predictive Factor;Predictive Value;Pregnancy;prenatal;Prenatal care;prevent;Provider;recruit;Research;Research Personnel;Risk;Risk Factors;Role;Scientist;screening;Screening procedure;Second Pregnancy Trimester;Serum;Shapes;Site;Small for Gestational Age Infant;stillbirth;Structure;Surface;Techniques;Testing;Time;tool;Ultrasonography

PROJECT_TITLE: A placenta-based strategy for improved clinical prediction of fetal growth trajectory using automated image analysis of placental morphology and vascularity

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Cancer;Liver Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse

ORG_CITY: Los Angeles

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative This renewal application for the Integrative Liver Cell Core (ILCC) proposes its continuation of unique and specialized services involving isolation and analysis of different liver cell types. As a national resource supported by the National Institute of Alcohol Abuse and Alcoholism, the ILCC provides these services at the regional and national levels to support medical research on alcohol-associated liver diseases and liver fibrosis, which are prevalent in our nation and around the world. The long-term goal of the ILCC is to help scientists develop new treatments for alcoholic-associated liver diseases and cirrhosis.

PI_NAMEs: TSUKAMOTO, HIDEKAZU  (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Alcohol abuse;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcoholic steatohepatitis;Alcoholism;Alcohols;Animals;California;career;cell bank;Cell Fate Control;Cell Lineage;cell repository;Cell Separation;cell type;Cells;Cellular biology;Chronic;Cirrhosis;clinically relevant;Collaborations;Communication;Communities;conditional knockout;Country;Couples;Diet;Disclosure;Disease;disease model;Endothelial Cells;Epigenetic Process;Ethanol;Evolution;Fatty Liver;feeding;Fibroblasts;Fibrosis;Fluorescence-Activated Cell Sorting;Funding;gain of function;Genes;Genetic;Goals;Grant;Hepatic;Hepatic Stellate Cell;Hepatocyte;Hybrids;Inflammation;Infusion procedures;innovation;Institution;interest;Knock-in;Knock-in Mouse;Liver;Liver Cirrhosis;Liver diseases;Liver Fibrosis;liver injury;Liver neoplasms;Macrophage;Macrophage Activation;Malignant neoplasm of liver;Medical Research;Mesenchymal;Mesothelial Cell;Metabolic;migration;Modeling;Molecular;mouse model;Mus;National Institute on Alcohol Abuse and Alcoholism;neutrophil;new therapeutic target;nonalcoholic steatohepatitis;novel;Outcome;Pathogenesis;Pathologic;Phenotype;Physiology;Play;Preparation;problem drinker;Procedures;progenitor;promoter;Publications;Reaction;Reporter;Research;Research Personnel;Research Support;Resources;response;Role;Sampling;Scientist;Services;stemness;synergism;Techniques;Testing;tumor initiation;tumorigenesis;Vitamin A

PROJECT_TITLE: Integrative Liver Cell Core


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: DALLAS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE This Medical District UTSW-D FIRST proposal is submitted jointly by the University of Texas Southwestern Medical Center (UTSW) and the University of Texas Dallas (UTD). These institutions have complementary strengths and a record of productive collaboration. They will offer an integrated FIRST approach to jointly recruit a cohort of exceptional and diverse scientists in three cluster areas of Biomedical Engineering (BME), Brain Science, and Cancer.

PI_NAMEs: FILBEY, FRANCESCA ;YIN, HELEN L (contact)

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Acceleration;Achievement;Address;Advocate;Appointment;Area;Awareness;Biomedical Engineering;Biomedical Research;Brain;Cancer Cluster;career;career development;cohort;Collaborations;Communities;community academic partnership;contextual factors;Data;Dedications;Department chair;design;Education;Educational workshop;effectiveness evaluation;empowerment;Endowment;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;evidence base;Exclusion;expectation;experience;Faculty;Fostering;Funding;Future;Future Teacher;gender equity;Goals;Grant;Health;implicit bias;improved;Inequity;innovation;Institution;Intervention;Joints;Laboratories;Leadership;Learning;Malignant Neoplasms;Marketing;Medical;Medical center;medical schools;meetings;Mentors;Mentorship;Methods;mid-career faculty;Modeling;Organizational Change;Pathway interactions;peer;peer coaching;Persons;Productivity;Program Development;programs;public health relevance;racial minority;recruit;Research;Research Personnel;Research Support;Scholars Program;Science;science, technology, engineering, mathematics, and medicine;Scientist;Services;success;synergism;Talents;Teacher Professional Development;Technology;tenure track;Testing;Texas;Training;Training Programs;Underrepresented Populations;Universities;virtual;Vocational Guidance;Woman;Work;Writing

PROJECT_TITLE: The Medical District UTSW-D FIRST Program


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: YIN, HELEN L (contact)

PROJECT_TERMS: Academic Medical Centers;Applications Grants;Area;Biomedical Engineering;Biomedical Research;Brain;career;cohort;Collaborations;college;Communities;community academic partnership;community engagement;Compensation;Data;design;Ecosystem;Educational workshop;empowerment;Ensure;Equity;equity, diversity, and inclusion;Evaluation;Extramural Activities;Faculty;Feedback;Fostering;Funding;Future;Future Teacher;Goals;Grant;high school;Home;implicit bias;improved;Institution;Joints;kindergarten;Laboratories;Leadership;Malignant Neoplasms;Marketing;Medical;Medical center;Mentors;Monitor;Morals;Organizational Efficiency;organizational structure;outreach;Pathway interactions;Population;post-doctoral training;Postdoctoral Fellow;Program Development;programs;Publications;racial minority;recruit;Research;Resources;Science;science, technology, engineering, mathematics, and medicine;Selection Criteria;Services;Structure;symposium;Talents;Teacher Professional Development;tenure track;Texas;Time;Training;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Vocational Guidance;web site;Woman;Writing

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-W]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Neurosciences;Nutrition;Prevention;Sleep Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Public Health Relevance Statement One in two adults in the U.S. have at least one cardiometabolic disease (CMD) including hypertension, heart disease diabetes or stroke. Despite links between short sleep duration and cardiometabolic health, few studies have sought to improve CMD risk by extending sleep. This study aims to evaluate the efficacy of a behavioral sleep extension intervention on sleep and CMD risk factors among patients with elevated blood pressure or hypertension. Successful completion of this study will advance the possibility of increasing sleep duration for improving cardiometabolic health.

PI_NAMEs: BARON, KELLY GLAZER (contact);DUFFECY, JENNIFER L

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Acute;Adult;Ambulatory Blood Pressure Monitoring;American;Area;Attention;attenuation;Behavior;behavior change;Behavior Therapy;Behavioral;Behavioral Model;Biological;Biological Markers;Blood Pressure;blood pressure elevation;Body fat;Body mass index;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular system;Cessation of life;Chronic Disease;Clinical;clinically significant;Cognitive Therapy;comparison control;comparison intervention;Control Groups;Coronary heart disease;design;Desire for food;Development;Diabetes Mellitus;Diet;diet and exercise;Disease Management;disorder risk;Drowsiness;Education;efficacy evaluation;efficacy testing;Electronic Mail;Evaluation;experimental group;experimental study;follow-up;glycemic control;Goals;group intervention;Health;Health behavior;Health education;Heart Diseases;Hypertension;improved;Inflammation;insulin sensitivity;Intervention;intervention effect;Knowledge;Life;Life Style;Link;Lipids;Maintenance;Measures;Mediator;Metabolic;Monitor;Motivation;motivational enhancement therapy;Outcome Study;Participant;Pathway interactions;Patient Outcomes Assessments;Patient Self-Report;Patients;Pattern;Personal Satisfaction;Phase;Physical activity;Physiological;pilot test;Population;prehypertension;primary outcome;programs;psychologic;public health relevance;Quality of life;Randomized, Controlled Trials;Research;Risk Factors;Sample Size;secondary outcome;Sleep;Sleep Deprivation;Sleep Disorders;sleep quality;Stroke;Sympathetic Nervous System;telephone coaching;Testing;theories;therapy development;Time;Unhealthy Diet;wearable device

PROJECT_TITLE: Effects of a behavioral sleep extension intervention on cardiometabolic risk factors among patients with elevated BP/hypertension

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: JOHNSON, JANE E (contact)

PROJECT_TERMS: Acceleration;Advocate;Area;Award;Awareness;Biomedical Engineering;Brain;career;career development;cohort;Collaborations;Committee Members;Communities;community organizations;Core Facility;cultural equity;Department chair;design;Development Plans;Educational workshop;empowerment;Ensure;Environment;Equity;Faculty;Fostering;Funding;Future;Geography;Grant;Group Meetings;Health;ImProv;improved;Individual;Influentials;innovation;Institution;inter-institutional;interdisciplinary collaboration;Interest Group;Joints;Leadership;Malignant Neoplasms;Maps;Medical;Mentors;Mentorship;microaggression;mid-career faculty;Modeling;Online Systems;Pathway interactions;Postdoctoral Fellow;professor;Program Development;programs;recruit;Research;Research Personnel;Science;science, technology, engineering, mathematics, and medicine;senior faculty;Social Network;Stress;success;Support System;symposium;Talents;Teacher Professional Development;tenure track;Texas;Training;Training Programs;Underrepresented Populations;Universities;Vocational Guidance;Work

PROJECT_TITLE: Faculty Development Core


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Most patients with HCC who are not candidates for surgical removal or ablation are treated with chemotherapeutic agents that in sufficient concentrations are potent enough to kill cancer cells. Nonetheless, these treatments result in only limited improvements in patient survival because these agents do not reach the cancer cells due to the abnormal tumor microenvironment. The proposed work will benefit public health by developing a novel image-guided approach for treating the tumor microenvironment of HCC with combined mechanotherapeutic drugs and ultrasound cavitation to increase chemotherapy delivery to the tumor.

PI_NAMEs: AVERKIOU, MICHALAKIS  (contact)

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: Ablation;Academia;Acute;advanced disease;Angiotensin Receptor;Animals;Anti-Hypertensive Agents;BAY 54-9085;Biological Availability;Biomedical Engineering;Biophysical Process;Blood Vessels;cancer cell;Cancer Etiology;cancer type;Cessation of life;Chemoembolization;chemotherapeutic agent;chemotherapy;Clinical;Clinical Research;Clinical Trials;Collaborations;curative treatments;Development;Diagnosis;Discipline;Disease;Dose;Doxorubicin;Drug Delivery Systems;Drug Targeting;Effectiveness;Eligibility Determination;Excision;Future;Genetic Engineering;Goals;Hepatotoxicity;human model;image guided;improved;in vivo Model;Industry;innovation;interest;Knockout Mice;Liver;liver cancer model;Losartan;Malignant Neoplasms;mechanical properties;Mechanics;Mediating;Microbubbles;Modeling;Monitor;mouse model;Nature;novel;novel therapeutic intervention;Oncology;Operative Surgical Procedures;Outcome;Patients;Pharmaceutical Preparations;Pharmacotherapy;precision medicine;preclinical efficacy;preclinical study;pressure;Primary carcinoma of the liver cells;Procedures;Property;Public Health;Research;Research Personnel;Resistance;response;Risk;Scientist;subcutaneous;synergism;Systemic Therapy;systemic toxicity;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapy outcome;Time;Toxic effect;Transplantation;Treatment Efficacy;Treatment outcome;tumor;tumor microenvironment;ultra high resolution;ultrasound;uptake;Work

PROJECT_TITLE: A novel paradigm of sensitization of the tumor microenvironment with image-guided ultrasound cavitation and mechanotherapeutics for targeted HCC treatment

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anorexia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Serious Mental Illness

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Anorexia nervosa (AN) is a serious psychiatric disorder associated with significant impairment and increased risk of death. This study will establish the extent to which neural bases of disgust generalization and extinction processes contribute to AN symptom expression, as well as determine the extent to which these patterns of neural activity predict AN symptom maintenance. By identifying the neurobiological processes underlying core symptom expression and maintenance in this population, the proposed research represents a critical next step needed to develop more precise models of AN and has potential for substantial impact on the development of innovative and effective neurobiologically-based treatments for this severe and persistent disorder.

PI_NAMEs: ANDERSON, LISA M (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Adult;Age;Amygdaloid structure;Anorexia Nervosa;arm;associated symptom;avoidance behavior;base;Behavioral;Biological;Biological Response Modifier Therapy;Biometry;Body Weight;career;Characteristics;Chronic;clinically significant;Computer Models;Conditioned Stimulus;conditioning;Consult;Crows;Cues;Data;Death Rate;design;Development;Diagnostic;Disease;Disease remission;Eating Disorders;eating pathology;efficacious treatment;emotion regulation;Emotions;Extinction;Failure;Fatty acid glycerol esters;follow-up;Food;food avoidance;Functional disorder;Goals;Impairment;Individual;innovation;Insula of Reil;Intake;Intervention;Knowledge;Learning;long term recovery;Maintenance;Measurement;Measures;Mental disorders;Mentors;Mentorship;Methods;Modeling;mortality risk;multimodality;neural;neural correlate;neural patterning;Neurobiology;neuroimaging;neuroregulation;novel;Participant;Pathologic;Pathology;patient oriented research;Pattern;Physiological;Population;Prefrontal Cortex;Preparation;Process;psychologic;Psychological reinforcement;Psychopathology;Psychopharmacology;Psychotherapy;Relapse;Research;Research Design;Research Personnel;Resistance;response;restrictive eating;Risk;severe mental illness;Severities;sex;skills;Stimulus;Stimulus Generalization;Symptoms;Testing;Theoretical model;theories;therapy resistant;Training;Training Activity;Translating;Translational Research;Translations;Update

PROJECT_TITLE: Neural Bases of Disgust Conditioning in Anorexia Nervosa

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Substance Misuse

ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: NARRATIVE Alcohol-associated liver disease (ALD) is the major cause of alcohol-related mortality, but the specific mechanisms underlying ALD development and progression have not been fully elucidated. We will develop a first-of-its-kind organotypic mouse liver model and investigate the effects of alcohol on multiple liver cell types in this model with comparisons to an in vivo mouse model of ALD that recapitulates several key features of human ALD. Our platform could be used to investigate the underlying molecular mechanisms by which cell-cell interactions in the liver determine progressive disease or adaptation due to chronic alcohol consumption.

PI_NAMEs: KHETANI, SALMAN R (contact);WEINMAN, STEVEN A

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: 3-Dimensional;Affect;alcohol effect;alcohol exposure;Alcoholic Liver Diseases;Alcohols;AODR mortality;Benchmarking;Biological Models;cell assembly;Cell Communication;Cell Physiology;Cell Separation;cell type;Cells;Cholesterol;chronic alcohol ingestion;Closure by clamp;Coculture Techniques;Collagen;comparison control;Complex;Coupled;Cytochrome P450;Data;Development;Diet;Dimensions;Disease;disease phenotype;Embryo;Encapsulated;Endothelial Cells;Engineering;Ethanol;Exclusion;Extracellular Matrix;Fibroblasts;fibrogenesis;Fibrosis;Fructose;Future;Gel;Gene Expression;Grant;Hepatic;Hepatic Stellate Cell;hepatocellular injury;Hepatocyte;Hepatotoxicity;Human;In Vitro;in vitro Model;in vivo;in vivo Model;Individual;Inflammatory;Inflammatory Response;Intestines;Kupffer Cells;Liver;Liver diseases;liver function;Malignant Neoplasms;Mediating;Microfluidics;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;nonalcoholic steatohepatitis;novel;Organ;Outcome;Pathogenesis;Pathology;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Physiological;Progressive Disease;Property;Recombinants;Research;Research Personnel;Resources;Role;Sampling;self assembly;single-cell RNA sequencing;spheroids;Steatohepatitis;System;Testing;Tissues;Trans Fats;transcriptome sequencing;Vertebral column;western diet

PROJECT_TITLE: Multicellular Organotypic Mouse Model of Alcoholic Liver Disease

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


PI_NAMEs: SMITH-MORRIS, CAROLYN  (contact)

PROJECT_TERMS: Address;Appointment;Attitude;Biomedical Engineering;Brain;Cancer Cluster;career;career development;cohort;Collaborations;Communication;cultural equity;Data;Data Set;design;Development;Educational workshop;Effectiveness;effectiveness evaluation;effectiveness measure;Ensure;Equity;equity, diversity, and inclusion;Evaluation;Faculty;faculty research;Feedback;Focus Groups;Funding;Future;Goals;Grant;Home;implicit bias;improved;Individual;innovation;Institution;Institutional Practice;Interdisciplinary Study;Interview;Joints;Laboratories;Leadership;Logic;Medical;Mentors;Methods;Modeling;operation;Outcome;Outcome Assessment;Output;Participant;Pathway interactions;Peer Review;Process;Process Measure;Productivity;professor;Program Development;programs;Publications;racial minority;recruit;Research;Science;science, technology, engineering, mathematics, and medicine;Standardization;Structure;Surveys;System;Talents;Teacher Professional Development;tenure track;Texas;tool;Training;Underrepresented Populations;United States National Institutes of Health;Vision;Woman;Work;Writing

PROJECT_TITLE: Evaluation Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Screening and Brief Intervention for Substance Misuse;Substance Misuse;Substance Misuse Prevention;Underage Drinking

ORG_CITY: FORT WORTH

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

PHR: Project Narrative Through innovative, comparative effectiveness research, we can improve interventions and develop individualized intervention strategies, which will reduce the serious negative consequences associated with heavy drinking and enhance the lives of adolescents and young adults. The results of this study will have a significant impact for all major stakeholders, including adolescents and young adults in need of treatment and their families, trial developers/researchers, school administrators. More broadly, this research will strengthen research practice, enhance transparency, and maximize the benefits of data sharing.

PI_NAMEs: MUN, EUN-YOUNG  (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: adaptive intervention;addiction;Administrator;Adolescent and Young Adult;alcohol intervention;alcohol research;Attention;behavior change;Behavioral Mechanisms;Big Data;Big Data to Knowledge;Biomedical Research;brief alcohol intervention;brief motivational intervention;career;career development;Clinical Data;Clinical Research;Clinical Trials;cohort;Cohort Effect;Collaborations;comparative effectiveness;Comparative Effectiveness Research;Computing Methodologies;Data;Data Aggregation;Data Analyses;data integration;Data Science;Data Set;data sharing;Data Sources;Databases;Development Plans;Dimensions;Disparate;Educational workshop;Eligibility Determination;Ensure;Environment;experience;Family;Future;Goals;Grant;Health Sciences;Healthy People 2020;Heavy Drinking;Heterogeneity;improved;Independent Scientist Award;Individual;innovation;insight;Intervention;intervention effect;Intervention Studies;Knowledge;Knowledge acquisition;learning strategy;Link;Liquid substance;machine learning algorithm;Medical Research;meetings;Meta-Analysis;Methods;Mission;multiple data sources;National Institute on Alcohol Abuse and Alcoholism;NIH Program Announcements;Outcome;Paper;Participant;Peer Review;personalized intervention;Population;precision medicine;Prevention;Problem Solving;programs;Publications;Publishing;Race;racial difference;Reading;Recording of previous events;Reporting;Research;research and development;Research Personnel;Sampling;Schools;sex;Sex Differences;skills;Statistical Methods;Strategic Planning;Sum;symposium;synergism;Technology;Testing;Time;tool;Training;underage drinking;underage drinking prevention;United States National Institutes of Health;university student;Update;uptake;Visit;Work;young adult

PROJECT_TITLE: Optimizing Brief Alcohol Interventions for Young Adults via Computational Methods

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Rural Health

ORG_CITY: LAWRENCE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: NARRATIVE The proposed project will increase the diversity of the scientific community by preparing students from underrepresented groups with a focus on American Indian students for graduate study and careers in biomedical research. The project will increase the size of the scientific workforce and increase interest in research regarding diseases with a high incidence in minority populations, improving both health care and disease prevention in this country.

PI_NAMEs: CARTWRIGHT, PAULYN  (contact);HANSON, PAUL R.

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: American Indians;analytical method;Biomedical Research;bridge to the baccalaureate;career;CCL7 gene;Classification;Collaborations;Communities;design;Development;Development Plans;Doctor of Philosophy;Eligibility Determination;experience;experimental study;faculty mentor;Foundations;Geography;Goals;graduate school;Individual;Institution;K-Series Research Career Programs;Kansas;Leadership;member;Mentors;multidisciplinary;outreach;Participant;Positioning Attribute;programs;recruit;Reproducibility;Research;Research Activity;responsible research conduct;Role;rural area;Science;Scientist;Students;suburb;symposium;Training;Training Programs;transfer student;undergraduate student;Underrepresented Populations;Universities;Writing

PROJECT_TITLE: MARC at The University of Kansas

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Cancer;Clinical Research;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE This Pediatric Oncology Clinical Research Training Program (POCRTP) provides a comprehensive clinical research educational program that trains pediatric oncologists in clinical research; the program seeks to produce the next generation of leaders in the field of pediatric cancer clinical research. The trainees, designated “Paul Calabresi Scholars,” receive a mentored training experience in the design, implementation, conduct, and analysis of clinical research trials. The ultimate goal of the POCRTP is to educate Scholars to translate basic research discoveries into innovative treatments using effective clinical trials, thereby improving the prognosis of children with cancer.

PI_NAMEs: ALLEN, CARL E (contact);PARSONS, DONALD W.

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: anti-cancer research;Applications Grants;Area;Basic Science;Cancer Center;Cell Therapy;Certification;Child;Childhood;Childhood Cancer Treatment;Clinical;clinical investigation;Clinical Oncology;Clinical Research;Clinical Trials;Clinical Trials Design;college;design;Development;Development Plans;Education;education research;Educational workshop;Eligibility Determination;Epidemiology;ethnic diversity;experience;Faculty;faculty mentor;Fellowship;Funding;Genomic medicine;Immunology;Individual;Institutional Review Boards;Instruction;Laboratories;Laboratory Research;Leadership;Manuscripts;Medicine;Mentors;Mentorship;multidisciplinary;Oncology;Pathway interactions;pediatric department;Pediatric Hematology;Pediatric Hospitals;Pediatric Oncology;Peer Review;Peer Review Grants;precision medicine;programs;Publishing;racial diversity;recruit;Research;Research Ethics;Scholars Program;Scholarship;Science;Scientist;Statistical Data Interpretation;summer program;survivorship;Texas;Therapeutic;Training;Training Programs;Translations;Underrepresented Populations;Writing

PROJECT_TITLE: PEDIATRIC ONCOLOGY CLINICAL RESEARCH TRAINING PROGRAM

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Clinical Research;Genetics;Women's Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE Patients with concerning breast masses require diagnosis, triage, and management; this typically depends on detailed examination of biopsy material, frequently obtained via core needles. However, such tissue-based diagnostics take time and skilled resources, and can induce delay in patient evaluation and appropriate care, especially in low-resource settings. We propose to develop an automated instrument into which needle biopsies of breast lesions can be introduced to immediately generate high-quality cellular-resolution and molecular stain images that can be used for diagnosis and treatment planning; the digital images can be interpreted locally, shared electronically, or even processed using artificial intelligence.

PI_NAMEs: LEVENSON, RICHARD M. (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Address;Antibodies;Antigen Targeting;Area;Artificial Intelligence;Biological Assay;Biopsy;Breast;Breast biopsy;Breast Cancer Patient;breast lesion;Caring;Chemistry;Classification;Clinic;Clinic Visits;Clinical;cloud based;Collection;Computer Assisted;Consumption;Core Biopsy;Coupled;Development;Devices;Diagnosis;Diagnostic;Diagnostic Imaging;digital;digital imaging;Disease;Ensure;ERBB2 gene;Evaluation;Fluorescence;Formalin;Goals;Hand;Histology;Histopathology;Human;Human Resources;Image;imaging software;Immunohistochemistry;Immunophenotyping;improved;Institutional Review Boards;instrument;Label;Laboratories;Ligands;Mammary Gland Parenchyma;Mass in breast;Mechanics;Molecular;Molecular Profiling;multiplexed imaging;Nature;Needle biopsy procedure;Needles;Nucleic Acids;Optics;Paraffin Embedding;Pathologist;Pathology;Patient Triage;Patients;Peptides;Periodicity;Phenotype;point of care;Preparation;preservation;Procedures;Process;Rapid diagnostics;rapid technique;rapid test;Reagent;Reproducibility;Research;Resolution;Resource-limited setting;Resources;sample fixation;Sampling;sensor;Site;skills;Slide;Specimen;Specimen Handling;Stains;Stream;System;Technology;Testing;Time;Tissues;tool;Training;Travel;treatment planning;treatment site;Triage;Validation;validation studies;Vial device;virtual

PROJECT_TITLE: CoreView and FIBI for rapid-onsite evaluation and molecular profiling of core-needle breast biopsies.


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Machine Learning and Artificial Intelligence;Precision Medicine;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Narrative In this study we are trying to find the genetic features that cause atrial fibrillation, a common abnormality of the heart rhythm that can lead to a stroke. We will also use an automated computer program to measure millions of pictures of the human heart to discover genes for the heart size and function. We then study the function of the genes that we find using heart cells; ultimately, we hope to find new drug targets for atrial fibrillation.

PI_NAMEs: BENJAMIN, EMELIA J.;ELLINOR, PATRICK THOMAS (contact);LUNETTA, KATHRYN L

PROGRAM_OFFICER_NAME: HONG, YULING

PROJECT_TERMS: Adherence;All of Us Research Program;Aorta;Atrial Fibrillation;biobank;Bioinformatics;Biological Assay;Biometry;Candidate Disease Gene;cardiac magnetic resonance imaging;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;causal variant;Cell Physiology;Cellular Structures;Cessation of life;ChIP-seq;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complement;computer program;connectin;cost;Data;Data Set;deep learning;deep learning model;Disease;disorder risk;diverse data;early onset;Electrophysiology (science);endophenotype;Epidemiology;Epigenetic Process;Etiology;Evaluation;exome;exome sequencing;Fellowship;Foundations;gene discovery;gene function;Generations;Genes;Genetic;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;genome sequencing;genome wide association study;genomic locus;Genomics;Health Care Costs;Heart;Heart Abnormalities;Heart Atrium;heart cell;heart dimension/size;Heart failure;heart function;heart rhythm;high risk;Histones;Human;human data;Image;Incidence;Individual;innovation;International;knock-down;Knock-out;knockout gene;Left;lifetime risk;loss of function;Maps;Measurement;Measures;Mediating;Mendelian randomization;Mentors;Morbidity - disease rate;mortality;multidisciplinary;Muscle Cells;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;new therapeutic target;novel;overexpression;polygenic risk score;Post-Translational Protein Processing;Prevalence;Prevention;Productivity;programs;Proteins;Public Health;Research;Research Personnel;Risk;Risk Factors;risk stratification;risk variant;single cell sequencing;stem cells;Stroke;stroke risk;Structure;success;Talents;Time;tool;Training;Training Programs;trait;Trans-Omics for Precision Medicine;transcriptome sequencing;Translating;United Kingdom;Variant;Viral;virtual;Work

PROJECT_TITLE: IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: We determined that AR interference activates the function of a network of cooperating transcriptional regulators that promote the lineage switch to treatment-emergent neuroendocrine prostate cancer (t-NEPC). The goal of this proposal is to determine mechanisms by which this network functions so we can block t-NEPC cell survival or prevent its emergence. A predicted outcome of our efforts is the identification of a new and effective treatment strategy for men with t-NEPC in the near-term.

PI_NAMEs: ALUMKAL, JOSHI JAMES (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: abiraterone;Acetylation;Androgen Receptor;ATAC-seq;biomarker identification;Bromodomain;Bromodomains and extra-terminal domain inhibitor;Cancer Patient;Castration;Cell Survival;ChIP-seq;Chromatin;Clinical Trials;Dependence;design;Disease Progression;Drug resistance;E2F transcription factors;effective therapy;enzalutamide;Exclusion;Gene Expression;Genes;Genetic Transcription;Goals;high risk;Histology;Histone Acetylation;histone acetyltransferase;Histone H3;Implant;In Vitro;Lead;loss of function;Lysine;Malignant neoplasm of prostate;Measures;men;Modeling;Mus;Neuroendocrine Prostate Cancer;Nucleic Acid Regulatory Sequences;Organoids;outcome prediction;Patients;pharmacologic;phase I trial;Phenotype;predictive marker;prevent;Program Sustainability;programs;Prostate Adenocarcinoma;prostate cancer cell;prostate cancer cell line;Proteins;Reader;receptor function;Receptor Signaling;Repression;Reproducibility;resistance mechanism;response;response biomarker;Sampling;Signal Pathway;Systems Biology;Testing;Time;transcription factor;Transcriptional Activation;transcriptome sequencing;treatment risk;treatment strategy;tumor;tumor growth;Virulent;Xenograft procedure

PROJECT_TITLE: Targeting Prostate Cancer Lineage Plasticity with BET Bromodomain Inhibition

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ORG_CITY: DETROIT

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE This project has high relevance to prostate cancer (PCa) and is expected to have a significant impact on current research and available treatments. Findings from this study will not only enhance our understanding of biology of bone marrow adipose tissue and its functional role in regulating the bone tumor microenvironment and metastatic progression, but it will lead to identification of novel candidate treatment options for improved patient outcomes. This work is likely to have high relevance beyond PCa and extend to other bone-trophic cancers.

PI_NAMEs: PODGORSKI, IZABELA  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Acylation;adipocyte biology;Adipocytes;Adipose tissue;Affect;Automobile Driving;Biology;bone;Bone Marrow;Bone neoplasms;cancer cell;cancer survival;Carrier Proteins;cell type;Chemoresistance;chemotherapy;Culture Techniques;Data;dimer;Disease;docetaxel;Environment;Enzymes;Exposure to;Fatty Acids;Fostering;genetic manipulation;Genetic Transcription;Glycolysis Pathway;Goals;Growth;heme oxygenase-1;improved;Interdisciplinary Study;Interleukin-1 beta;Interleukins;Iron;Iron Chelating Agents;Iron Chelation;iron metabolism;Laboratories;Link;Lipase;Lipid Mobilization;Lipids;Lipolysis;liquid chromatography mass spectrometry;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Marrow;Mass Spectrum Analysis;Mediating;Metabolic;Metabolism;Metastatic Prostate Cancer;Mitochondria;mitochondrial metabolism;Modeling;Modification;Molecular;Molecular Conformation;monomer;mouse model;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;Obesity;Organ;Oxidative Stress;paracrine;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;pharmacologic;Phenotype;Post-Translational Protein Processing;Process;prostate cancer cell;prostate cancer progression;Protein Kinase;Proteomics;Publishing;Pyruvate Kinase;Regulation;Research;Research Personnel;Resolution;response;Role;Sampling;Signal Transduction;Signaling Molecule;Site;Site-Directed Mutagenesis;Skeleton;Source;stem;stoichiometry;Structure;targeted treatment;Testing;Therapeutic Effect;three dimensional cell culture;Tissues;transcriptome sequencing;treatment response;tumor;tumor growth;tumor metabolism;tumor microenvironment;tumor progression;Tumor Promotion;uptake;Work;Xenograft Model

PROJECT_TITLE: Adipocyte regulation of tumor survival in metastatic prostate cancer: new targets for therapy

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Recent studies have revealed that senescent stromal cells can secret factors to modulate tumor immune surveillance and thus promote tumor progression. Given that such factors have been identified in human breast cancer tissues across molecular subtypes and immunotherapy response amongst breast cancer patient is far from ideal, it is critical to understand how senescent stromal cells contribute to mammary gland tumorigenesis. The aims proposed here will not only broaden our understanding in how senescent stroma shapes tumor microenvironment but also help to identify potential strategies to improve response to immunotherapy by targeting cellular senescence.

PI_NAMEs: YE, JIAYU  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: age related;age related changes;Aging;American;AP20187;bench to bedside;Bioinformatics;Breast Cancer Cell;Breast Cancer Patient;Cancer Biology;cancer subtypes;cancer therapy;career;Cell Aging;Cell Proliferation;Cells;cellular targeting;chemokine;cytokine;Data Set;Development;Diagnosis;Environment;Enzymes;Fibroblasts;Gene Expression Profile;Genetic;Goals;Heterogeneity;Human;Immune;immune cell infiltrate;immune checkpoint blockade;Immunohistochemistry;Immunologic Surveillance;Immunology;Immunotherapy;improved;Infiltration;Injections;Ink;interest;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary gland;Mammary Neoplasms;Mediating;Modeling;molecular subtypes;Mouse Mammary Tumor Virus;mouse model;Mus;Mutation;Neoplasm Transplantation;neoplastic cell;novel therapeutic intervention;Oncogenic;Partner in relationship;Penetrance;pharmacologic;polyoma middle tumor antigen;Population;Proliferating;Refractory;Regulatory T-Lymphocyte;Research;response;Risk;Risk Factors;Role;senescence;senescence associated secretory phenotype;senescent cell;Shapes;single cell analysis;single-cell RNA sequencing;skills;Stromal Cells;suicide gene;T cell infiltration;Tissues;tool;Training;training opportunity;Transgenic Mice;Transgenic Organisms;translational medicine;transplant model;triple-negative invasive breast carcinoma;tumor;Tumor Burden;tumor growth;Tumor Immunity;tumor immunology;tumor microenvironment;tumor progression;Tumor Promotion;tumor-immune system interactions;tumorigenesis;Woman;Work

PROJECT_TITLE: Understanding how senescent stromal cells contribute to mammary gland tumorigenesis


ORG_CITY: IOWA CITY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The University of Iowa (UI) Maximizing Access to Research Careers (MARC) program provides ongoing and intense academic and research support to undergraduate students and faculty research mentors in an effort to increase the rate of disadvantaged and underrepresented students matriculating to and completing biomedical doctoral research programs. The UI MARC program directly contributes to NIH’s effort of increasing the diversity of the biomedical workforce ensuring NIH remains a leader in scientific innovation and discovery. Supporting a diverse workforce, particularly a diverse group of research investigators, brings a wide range of perspectives and experiences to solve complex programs, and increases the likelihood that research questions related to human health are relevant to all populations.

PI_NAMEs: ADAMS-PHILLIPS, LORI C (contact);FORBES, TORI

PROJECT_TERMS: Area;Bachelor's Degree;Biomedical Research;Capital;career;career development;college;Communication;Degree program;Development;Doctor of Medicine;Doctor of Philosophy;economic disparity;Ensure;evidence base;experience;Faculty;faculty mentor;First Generation College Students;Graduation Rates;innovation;Institution;Iowa;K-Series Research Career Programs;Mentors;Mission;Population;Program Evaluation;programs;Reproducibility;Research;Research Personnel;Research Training;retention rate;Science;student training;Students;successful intervention;Training;undergraduate student;underrepresented minority student;Underrepresented Students;United States National Institutes of Health;Universities;Vocational Guidance

PROJECT_TITLE: MARC at University of Iowa


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The application of immunotherapy to breast cancer has been largely unsuccessful, even though tumors are infiltrated with many immune cells. Our proposal aims to reveal how the spatial organization and cellular interaction networks of intratumoral leukocytes regulate tumor progression and regression. Our findings may provide a better rationale for immunotherapy development and/or selection in breast cancer, paving the way for eventual clincal advancements.

PI_NAMEs: SAGLIMBENI, JOSEPH ANTHONY (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Address;Affect;Antigen Presentation;Antitumor Response;Area;Bone Marrow;Breast Cancer Patient;breast cancer progression;Breast Cancer therapy;cancer cell;Cancer Etiology;cancer type;Cell Communication;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;Communication;cytokine;Data;Dendritic Cells;Development;Dimensions;Disease;Disease Outcome;Disease Progression;Doxorubicin;fetal;fluorescence imaging;Genetic;Goals;high dimensionality;Hyperplasia;Imaging technology;Immune;immune cell infiltrate;Immunophenotyping;immunosuppressed;Immunosuppression;Immunotherapy;In Situ;in situ imaging;Infiltration;interest;Investigation;Leukocytes;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Neoplasms;Molecular;mortality;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;novel;organizational structure;Paclitaxel;Patient-Focused Outcomes;Patients;Pattern;pharmacologic;Phenotype;Population;Positioning Attribute;Production;prognostic;Regulatory T-Lymphocyte;Relapse;response;Role;spatiotemporal;standard of care;T-Lymphocyte;Technology;Testing;Tissues;tumor;Tumor Antigens;tumor growth;Tumor Immunity;tumor initiation;tumor microenvironment;tumor progression;Tumor stage;Tumor-associated macrophages;Tumor-infiltrating immune cells;tumorigenesis;United States;Visualization

PROJECT_TITLE: Investigating the Spatial Dynamics of Intratumoral Immune Cells in Breast Cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Immunotherapy;Liver Disease;Microbiome;Nutrition

PHR: PROJECT NARRATIVE This project seeks to characterize the prebiotic and immune mechanisms underlying the benefits of eicosapentaenoic acid (EPA) for improving post-operative survival of patients with colorectal cancer liver metastasis (CRCLM) by leveraging the recently launched, randomized placebo-controlled phase III trial of EPA treatment in patients undergoing liver resection surgery for CRCLM. We will also address causality and mechanism with dietary and microbial interventions in a novel ‘avatar’ germ-free CRCLM mouse model which is ‘humanized’ with stool from trial participants. Based on these unique resources and our experienced transdisciplinary team, the proposed research will provide unprecedented insight into the prebiotic and tumor immunomodulatory effect of EPA to improve the prognosis and response to surgical resection of CRCLM, offering compelling translational evidence for novel dietary and microbial strategies for CRCLM treatment.

PI_NAMEs: CHAN, ANDREW T (contact);GARRETT, WENDY S.;HULL, MARK A

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Address;adenoma;Aftercare;Anti-Inflammatory Agents;anti-tumor immune response;Bacteria;beneficial microorganism;Bifidobacterium;biobank;Biological Markers;Blood;Blood specimen;Cancer Etiology;cancer immunotherapy;cancer survival;Cessation of life;chemokine;Chronic;Clinical;cohort;colon cancer patients;Colorectal Adenoma;Colorectal Cancer;colorectal cancer progression;colorectal cancer treatment;Colorectal Surgery;combinatorial;cost;CTLA4 gene;Data;density;Diet;dietary;Dietary Fats;dietary supplements;Dinoprostone;Dose;Eicosapentaenoic Acid;Escherichia coli;Esters;Etiology;Excision;experience;fecal transplantation;Feces;follow-up;Food;Frequencies;Funding;Fusobacterium nucleatum;Germ-Free;Gnotobiotic;Growth;gut bacteria;gut microbiota;host-microbe interactions;Human;Human Microbiome;Immune;immune checkpoint;immunoregulation;Immunosuppression;improved;improved outcome;Inflammation;Inflammation Mediators;Inflammatory;insight;Intervention;Investigation;Lactobacillus;Ligands;Lipopolysaccharides;Liver;marine;Mediating;Metabolic;Metastatic Neoplasm to the Liver;Microbe;microbial;microbiome;microbiome research;microbiota;Morbidity - disease rate;mouse model;Mus;Myeloid-derived suppressor cells;Neoplasm Metastasis;new therapeutic target;novel;Omega-3 Fatty Acids;Operative Surgical Procedures;Outcome;Participant;Pathway interactions;Patient Recruitments;patient subsets;Patient-Focused Outcomes;Patients;permissiveness;Phase;phase III trial;Placebo Control;Plasma;Postoperative Period;prebiotics;predicting response;predictive marker;Probiotics;Production;Prognosis;programmed cell death protein 1;Progression-Free Survivals;Property;prospective;Randomized;randomized placebo controlled trial;Regional Cancer;Regulatory T-Lymphocyte;Research;Resources;responders and non-responders;response;Role;Safety;Specimen;Standardization;stool sample;Structure;Supplementation;System;systemic inflammatory response;Testing;Tissues;Transplant Recipients;tumor;Tumor Burden;Tumor Escape;tumor growth;Tumor Immunity;tumor microenvironment;tumorigenic;urinary;Urine

PROJECT_TITLE: Prebiotic effect of eicosapentaenoic acid treatment for colorectal cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: CLEVELAND

ORG_NAME: HAIMA THERAPEUTICS, LLC

ORG_STATE: OH

PHR: Project Narrative Thrombocytopenia is a condition characterized by low platelet counts; patients with thrombocytopenia are at risk of excessive, uncontrollable bleeding. The current standard of care is transfusion with donor platelet products to mitigate bleeding risks. However, donor platelets are expensive, carry significant risk of infections, have variable hemostatic efficacy, and have very short shelf life (3-5 days). Our innovative SynthoPlateTM technology can mimic platelet’s hemostatic functions while providing advantages of large-scale production and sterilizability to reduce contamination risk and ensure long shelf life.

PI_NAMEs: BRUCKMAN, MICHAEL ARTHUR (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Address;Adhesions;Affect;Age;Alloimmunization;Animal Model;Antibodies;appropriate dose;Autoimmune Diseases;Award;Binding;Biological Assay;Biological Markers;Bleeding time procedure;Blood;Blood Platelets;Blood specimen;Cardiovascular system;chemotherapy;Clinic;Clinical;clinical application;clinical biomarkers;Clinical Protocols;Clinical Research;clinical translation;clinically relevant;Coagulation Process;Collaborations;Collagen;Consumption;Data;Dependence;design;Development;dosage;Dose;Drug Kinetics;Drug Side Effects;Ear;Ensure;Evaluation;experimental study;Fibrinogen;Funding;Future;Guidelines;Hemorrhage;Hemostatic Agents;Hemostatic function;Heparin;high risk;Human;Idiopathic Thrombocytopenic Purpura;Immune;Immune response;improved;In Vitro;in vivo;Infection;infection risk;Injury;innovation;Intravenous;Kinetics;Laceration;large scale production;Life;manufacture;Measures;Microfluidics;mimetics;Minor;Modeling;Monitor;mouse model;Mus;nanoparticle;Nanotechnology;New Zealand;Operative Surgical Procedures;Oryctolagus cuniculus;Patients;Peptides;peptidomimetics;Persons;Pharmaceutical Preparations;Pharmacodynamics;Pharmacologic Substance;Phase;phase 2 study;Platelet Activation;Platelet aggregation;Platelet Count measurement;Platelet Transfusion;Prevalence;product development;Production;prophylactic;Radiation therapy;Recommendation;recruit;Refractory;Reproducibility;research clinical testing;Risk;Site;Small Business Innovation Research Grant;Source;standard of care;success;System;Tail;Technology;Testing;Therapeutic;Therapeutic Agents;Thrombocytopenia;Transfusion;von Willebrand Factor;wasting;Weight

PROJECT_TITLE: SynthoPlate: Intravenous Hemostatic Nanotechnology to Mitigate Bleeding in Thrombocytopenia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(10)B]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Aging;Arthritis;Cannabidiol Research;Cannabinoid Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Natural Products;Neurosciences;Osteoarthritis;Pain Research;Therapeutic Cannabinoid Research

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Our aim is to unify state-of-the-art chronic pain phenotyping methods, such as experimental pain testing and neuroimaging, with cannabinoid analgesic mechanisms in knee osteoarthritis patients. Our results will contribute significantly to the fundamental understanding of cannabinoid analgesic effects on central and peripheral contributions to knee osteoarthritis pain. Further, we have shown that this phenotyping approach is applicable to many other chronic pain conditions, so our results will have broad implications for developing personalized, non-opioid analgesics for pain management.

PI_NAMEs: HARRIS, RICHARD E;HARTE, STEVEN EDWARD (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Absence of pain sensation;abuse liability;Address;Adverse effects;Adverse event;Affect;American;Analgesics;Anti-Inflammatory Agents;Antiinflammatory Effect;Area;Brain;C-reactive protein;Cannabidiol;Cannabinoids;Cannabis sativa plant;Central Nervous System;central pain;chronic pain;chronic painful condition;Clinical;Clinical Trials;clinically relevant;Data;Degenerative polyarthritis;design;disability;Dose;Double-Blind Method;Dronabinol;Epidiolex;Exposure to;Functional disorder;functional improvement;Harm Reduction;Hydroxyl Radical;improved;indexing;Individual;Inflammation;inflammatory marker;Insula of Reil;Interleukin-6;Intervention;joint injury;Knee;Knee Osteoarthritis;knee pain;Link;Magnetic Resonance Imaging;Measures;men;Methods;Neurobiology;neurochemistry;neuroimaging;Nociception;non-opioid analgesic;Operative Surgical Procedures;Opioid;opioid epidemic;osteoarthritis pain;Outcome;Pain;Pain management;pain processing;pain reduction;pain symptom;painful neuropathy;Participant;Patient Outcomes Assessments;Patients;Peripheral;Peripheral Nervous System;peripheral pain;Persons;Pharmaceutical Preparations;Phenotype;Placebos;precision medicine;Preparation;radiological imaging;Randomized;Reporting;Research Design;response;Running;secondary analysis;Sensory;Series;side effect;Symptoms;Testing;Tetrahydrocannabinol;Tissues;translational model;treatment response;Work

PROJECT_TITLE: Cannabinoid interactions with central and peripheral pain mechanisms in osteoarthritis of the knee

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The substantial variability in the presentation of autism (ASD) is a key barrier in early diagnosis and in developing and evaluating effective treatments for the disorder. Because of this, the NIH and the Interagency Autism Coordinating Committee (IACC) have pushed to better understand the causes and impacts of this variability in individuals with ASD. The proposed project responds to this critical need by clarifying the impact of a potential key source of this variability: co-occurring anxiety and ADHD.

PI_NAMEs: CARPENTER, KIMBERLY L H (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Adolescent;Adult;Affect;Anxiety;Anxiety Disorders;anxiety spectrum disorders;anxiety symptoms;associated symptom;Attention;Attention deficit hyperactivity disorder;attentional bias;autism spectrum disorder;autistic children;Behavior Therapy;Behavioral;Biological Assay;Biological Markers;biomarker identification;biomarker signature;Characteristics;Child;Clinical;Cognitive;Computer Vision Systems;Cues;Development;Diagnosis;Disease;dual diagnosis;early childhood;Early Diagnosis;Early treatment;effective therapy;Electroencephalography;Executive Dysfunction;executive function;Face;flexibility;functional outcomes;Heterogeneity;improved;improved outcome;inattention;Individual;individualized medicine;individuals with autism spectrum disorder;Knowledge;Light;Literature;Maps;Measures;Methods;Monitor;movement analysis;multimodality;National Institute of Child Health and Human Development;neural;Neurobiology;neuromechanism;neurophysiology;Outcome;Parents;Pattern;peer;Phenotype;Process;programs;Provider;Questionnaires;Reporting;Research;Resources;response;Retrospective Studies;Sampling;social;social deficits;Social Functioning;Source;Subgroup;Symptoms;Testing;treatment response;United States National Institutes of Health;Variant;visual tracking;Work

PROJECT_TITLE: Stratifying the Heterogeneity of Autism Spectrum Disorder: Impact of Co-Occurring Anxiety and ADHD

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Infectious Diseases;Prevention;Social Determinants of Health

PHR: Project Narrative Social networks are a key determinant of health: directly through pathogen diffusion and indirectly through peer influence processes or role behaviors characteristic of a particular network position. While there is growing recognition of the importance of networks for health, training programs for health scholars almost never include social networks methodology training. This program will provide comprehensive training on the core ideas of social network analysis relevant for health training to produce a cohort of researchers prepared to leverage new network data for promoting health.

PI_NAMEs: MOODY, JAMES  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Affect;Awareness;base;Behavior;Belief;Characteristics;Code;cohort;Collaborations;Communicable Diseases;Communication;Communities;Complex;complex data;Computer Models;Country;course sequence;Data;Data Analyses;Data Collection;data management;dietary;Diffusion;Education;Educational workshop;empowerment;experience;Experimental Designs;experimental study;Feedback;flu;Fostering;Grant;Growth;Health;Health behavior;health determinants;health disparity;Health Policy;Health Promotion;Health Sciences;health training;Healthcare;Heterogeneity;HIV;innovation;insight;Instruction;interest;Investments;learning materials;learning network;lectures;Life;Mathematics;Measurement;Mentors;Methodology;Methods;Nature;network models;next generation;novel;online resource;Outcome;Paper;Participant;pathogen;Pathway Analysis;peer;peer influence;Persons;Phase;Population;population health;Positioning Attribute;power analysis;Process;programs;Publishing;Research;Research Personnel;Resources;Risk Behaviors;Role;Sampling;satisfaction;Science;Scientist;Services;Shapes;simulation;skills;Slide;Social Network;Social Sciences;Statistical Models;System;Techniques;Training;training opportunity;Training Programs;transmission process;Work

PROJECT_TITLE: Focused Training in Social Networks and Health

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


NIH_SPENDING_CATS: Bioengineering;Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE We have determined that histotripsy, a novel technology that ablates tumors precisely and non-invasively using high intensity ultrasound waves, triggers a sequence of cell death events in treated and distant, untreated tumors that culminate in a systemic anti-tumor immune response that is stronger than that generated by existing modes of tumor ablation. We will examine three distinct cellular events that follow histotripsy ablation – the exposure of contents hidden inside tumor cells, the triggering of inflammatory cancer cell suicide of cancer cells, and immune cell-driven cancer cell death – to determine the extent to which these unique events mechanistically drive the phenomenon of histotripsy immunostimulation. By understanding these events and testing preclincal strategies to harness and maximize them, we hope to establish a scientific foundation for implementing histotripsy tumor ablation as a means of maximizing the impact of cancer immunotherapy.

PI_NAMEs: CHO, CLIFFORD  (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Ablation;Abscopal effect;adaptive immune response;adaptive immunity;anti-tumor immune response;Antigen-Presenting Cells;Antigens;Attention;cancer cell;cancer immunotherapy;carcinogenesis;CD8-Positive T-Lymphocytes;Cell Communication;Cell Death;cell killing;cell suicide;Cells;Cessation of life;checkpoint inhibition;Clinical;clinical practice;clinically relevant;Colon Carcinoma;cytotoxicity;Data;Detection;Distant;Event;Focused Ultrasound;Focused Ultrasound Therapy;Foundations;Future;Heating;Immune;Immune checkpoint inhibitor;Immune response;Immune system;immunogenic;immunogenic cell death;immunogenicity;Immunologic Stimulation;Immunology;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Infiltration;Inflammation;Inflammatory;inhibitor;insight;Intervention;Investigation;Ionizing radiation;Length;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mechanics;Mediating;Melanoma;Metabolic;millimeter;Modality;mouse model;multidisciplinary;neoplastic cell;new technology;Pathway interactions;Patients;Physiologic pulse;pre-clinical;preservation;Process;Radiation;Role;Series;Signal Transduction;Site;T cell infiltration;T-Cell Depletion;Technology;Testing;Therapeutic;Thermal Ablation Therapy;Tissues;traditional therapy;Translating;tumor;tumor ablation;Tumor Antigens;Ultrasonic wave;Work

PROJECT_TITLE: Harnessing the therapeutic potential of histotripsy focused ultrasound-induced immunogenic cancer cell death

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-J(03)M]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Immunotherapy;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stomach Cancer

ORG_CITY: CORAL GABLES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: This study investigates how chronic stimulation by cytokines leads to inflammation and cancer in the stomach. The knowledge generated from this study will help design strategies to break the link between inflammation and cancer development as well as to block pro-tumor inflammatory signal while preserving the anti-tumor effectors for cancer prevention and treatment.

PI_NAMEs: CHEN, ZHIBIN  (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: 3-Dimensional;Ablation;Adenocarcinoma;Adoptive Transfer;Affect;Age;Age Years;American;Animal Model;anti-CTLA4;Antibody Therapy;Atrophic Gastritis;Autoimmunity;Bone Marrow;cancer cell;cancer initiation;cancer prevention;cancer therapy;CD4 Positive T Lymphocytes;Cell Differentiation process;Cells;Chief Cell;Chimera organism;Chronic;connective tissue growth factor;CTLA4 blockade;CTLA4 gene;CTLA4 haploinsufficiency;cytokine;Cytokine Receptors;Data;design;Development;Disease;DNA Sequence Alteration;Dysplasia;Environmental Risk Factor;Epithelial Cells;Epithelium;Etiology;Exhibits;Gastric Adenocarcinoma;Gastric Metaplasia;gastric organoids;Gastritis;Genes;Genetic;Genetic Polymorphism;Genetic Predisposition to Disease;Genetic study;germ free condition;Goals;Growth Factor;Helicobacter pylori;heparin-binding EGF-like growth factor;Human;human model;IL13 gene;IL4 gene;Immune;Immunophenotyping;Inflammation;Inflammatory;insight;Integration Host Factors;Interleukin 4 Receptor;Interleukin-13;interleukin-13 receptor;knock-down;Knock-out;Knowledge;LGR5 gene;Link;Lymphoid Cell;Malignant - descriptor;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Metaplasia;Modeling;Monoclonal Antibodies;Mucous Membrane;Mus;Neoplasms;neoplastic;Neoplastic Cell Transformation;Not Hispanic or Latino;novel;overexpression;Pathway interactions;Patients;Penetrance;Play;potential biomarker;Premalignant Cell;preneoplastic cell;preservation;Proliferating;Reporting;RNA Interference;Role;Signal Transduction;small hairpin RNA;spasmolytic polypeptide;stem cell expansion;stem cell population;stem cells;Stomach;Surveys;T-Lymphocyte;Testing;Th2 Cells;Tissues;transdifferentiation;Transgenes;Transgenic Organisms;trefoil factor;tumor;Tumor Immunity;tumorigenesis;White Women

PROJECT_TITLE: The role of type 2 inflammation in the initiation and progression of metaplastic differentiation and neoplastic transformation of gastric epithelia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


ORG_CITY: ATHENS

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative  This project aims at developing and testing sodium chloride nanoparticles as a novel intravesical therapy for non-muscle-invasive bladder cancer. It is hypothesized that sodium chloride nanoparticles can be instilled into affected bladder for efficient cancer cell killing. After the treatment, sodium chloride nanoparticles are degraded to non-toxic salts and excreted via urine or absorbed by the host, causing minimal local and systemic toxicity.

PI_NAMEs: KIM, WILLIAM Y.;LI, ZIBO ;XIE, JIN  (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: Ablation;absorption;Affect;Aftercare;anti-cancer;Apoptosis;appropriate dose;Bacterial Vaccines;BCG Live;BCG Vaccine;Biocompatible Coated Materials;Bladder;Bladder Neoplasm;cancer cell;Cancer cell line;cancer diagnosis;Cancer Patient;cancer type;Categories;cell killing;Cell membrane;Cells;Cellular Metabolic Process;Chemotherapy and/or radiation;clinical translation;cytochrome c;cytotoxicity;Development;Diagnosis;Dose;Electrolytes;Endocytosis;Epirubicin;Excretory function;Formulation;gemcitabine;Goals;high risk;HMGB1 gene;Human;Immune checkpoint inhibitor;Immune system;Immunity;Immunocompetent;immunogenic cell death;In Vitro;in vivo;intravesical;Intravesical Instillation;Ions;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of liver;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;manufacture;Measures;Mitochondria;mitochondrial membrane;Mitomycins;Modeling;Morbidity - disease rate;Mus;Muscle;nanomedicine;nanoparticle;Necrosis;neoplastic cell;non-muscle invasive bladder cancer;Normal Cell;Normal tissue morphology;novel;Operative Surgical Procedures;Osmolalities;Osmolar Concentration;Osmotic Shocks;Oxidative Stress;particle;Patients;Phospholipids;prevent;Production;Prognosis;Progression-Free Survivals;Property;Quality of life;Radical Cystectomy;Recommendation;Recurrent tumor;Resistance;Salts;Scheme;side effect;Skin Cancer;Sodium;Sodium Chloride;Swelling;systemic toxicity;Testing;Therapeutic;therapeutic nanoparticles;Toxic effect;Transurethral Resection;Treatment Efficacy;tumor;Tumor Immunity;Urethra;Urinary Diversion;Urination;Urine;Urothelial Cell;Water;Xenograft Model

PROJECT_TITLE: Development of a novel biodegradable inorganic nanoparticle therapeutic for cancer


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative This project is to determine whether low dose environmental cadmium (Cd), at levels found in the human diet, interacts with viral infection to disrupt the central mechanism for cell growth and proliferation, and potentiates fibrosis in mouse lungs. Lung diseases are among the top causes of human morbidity and mortality; the proposed research could decrease adverse impact of environmental Cd and virus infection on lung disease.

PI_NAMEs: GO KANG, YOUNG-MI  (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Affect;Age;Antioxidants;Asthma;Autophagocytosis;Biology;Bronchiolitis;Cadmium;cell growth;Cell model;Cell Proliferation;Cell Survival;Cells;Cellular biology;Cessation of life;Communities;Complex;Cysteine;Data;Development;Diet;disease registry;Dose;Elderly;Energy Metabolism;Environmental Impact;Excision;experience;Experimental Animal Model;Exposure to;fatty acid biosynthesis;fatty acid metabolism;Fatty Acids;Fibroblasts;Fibrosis;Food;FRAP1 gene;genetic manipulation;Glycolysis;high risk infant;Hospitalization;Human;human morbidity;human mortality;Infant;Infection;Inflammation;Inflammatory;inhibitor;Interstitial Lung Diseases;late life;Link;lipid biosynthesis;lipid metabolism;Lipids;Literature;Lung;Lung Diseases;lung injury;Measures;Mediating;Metabolic;Metabolic stress;metabolome;Metals;Methods;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Mitochondrial Proteins;Molecular;Molecular Target;Morbidity - disease rate;mouse model;Mus;non-smoker;non-smoking;Oxidants;oxidation;Oxidation-Reduction;Oxidative Stress;palmitoylation;Pathogenesis;Pathology;Pathway Analysis;Pathway interactions;pharmacologic;Pneumonia;Poison;Population;Post-Translational Protein Processing;Predisposition;programs;protein function;protein metabolite;Protein S;Proteins;Proteome;Public Health;Pulmonary Fibrosis;pulmonary function;Research;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;response;Risk;Role;senescence;Severities;Signal Transduction;Structure;Testing;Toxic effect;Transcript;transcriptome;TXN gene;Virus Diseases;Zinc Fingers

PROJECT_TITLE: Cadmium-potentiated metabolic reprogramming in pathogenesis of lung fibrosis

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Social Determinants of Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE This proposal will use a novel model of human fertility - vitrified donor oocyte assisted reproductive technology (ART) - to evaluate how air pollution influences human reproduction. Because vitrified oocytes are obtained from anonymous, young, healthy female donors months to years prior to the recipient couple's ART cycle, there is no correlation in exposure between the donor and the female recipient or the donor and the recipient's male partner. By leveraging this unique resource, our research will determine the independent effects of air pollution exposure during oogenesis and spermatogenesis on fertilization and early embryo development, the independent effects of air pollution on pregnancy outcomes as mediated through the oocyte and the endometrium, and the extent to which air pollution affects fertility potential in young, healthy women.

PI_NAMEs: GASKINS, AUDREY JANE (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Address;Adverse effects;Affect;Air Pollution;ambient air pollution;Antral;Assisted Reproductive Technology;Autologous;Biological;Birth Rate;Birth Weight;blastocyst;Carbon;Carbon Monoxide;China;Clinic;Clinical;coarse particles;cohort;cost effective;Couples;Development;Elements;Embryo;embryo cryopreservation;embryo quality;Embryo Transfer;Embryonic Development;Endometrial;Endometrium;Environment;Environmental Exposure;epidemiology study;Europe;Event;Exposure to;Female;Fertility;Fertility Rates;Fertilization;Germ Cells;Gestational Age;global health;Health;Human;human model;implantation;Infertility;Knowledge;Link;Live Birth;male;Mediating;Medical Assistance;men;Modeling;Motor Vehicles;Nitrogen Dioxide;Nitrogen Oxides;novel;Oocyte Donation;oocyte quality;Oocytes;Oogenesis;Outcome;ovarian reserve;Ovarian Stimulations;Ozone;Paternal Exposure;Patients;Physicians;pollutant;Population;Predisposition;Pregnancy;Pregnancy loss;Pregnancy Outcome;Premature Birth;Privatization;Probability;Reproduction;reproductive;reproductive outcome;Research;Resources;Risk;Sampling;Sex Ratio;spatiotemporal;sperm cell;Spermatogenesis;Sulfur Dioxide;Time;traffic-related air pollution;United States;Uterus;Woman

PROJECT_TITLE: The Influence of Ambient Air Pollution on Fertility Using a Vitrified Donor Oocyte Bank

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The interdisciplinary research training provided by this program will advance the application of bioengineering technologies in improving scientific understanding of cardiovascular and cardiopulmonary diseases and developing new diagnostics, therapeutics, clinical management and prevention measures. It will train a scientific workforce that uses modern bioengineering to reduce incidence and improve outcomes in patients with heart, lung, vessel, blood and sleep disorders.

PI_NAMEs: CHRISTMAN, KAREN L;MCCULLOCH, ANDREW D. (contact);SCHMID-SCHOENBEIN, GEERT W.

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Biomedical Engineering;Cardiopulmonary;Cardiovascular system;Disease;Health;research and development;technology development;Training

PROJECT_TITLE: Training in Bioengineering Research and Technology Development in Cardiovascular in Cardiopulmonary Health and Disease

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Over the past decade, technologies that enable precision medicine have markedly improved, enabling the detection and analysis of a variety of soluble biomarkers, now referred to as the blood biopsy. In particular, assessment of circulating tumor DNA (ctDNA) is increasingly being used for therapeutic decision-making in cancer patients; however, several challenges remain before this approach can be effectively implemented to truly advance treatment and prevention outcomes. The purpose of this grant application is to leverage the spontaneous canine cancer model to optimize a set of novel tools and methodologies for ctDNA based blood biopsy that facilitate early screening, minimal residual disease monitoring and interrogation of tumor genome evolution, with the goal rapid translation to human oncology.

PI_NAMEs: KARLSSON, ELINOR  (contact);LONDON, CHERYL A

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: actionable mutation;Address;Affect;Aftercare;anti-cancer treatment;Applications Grants;B-Cell Lymphomas;Benchmarking;Biological Assay;Biological Markers;Biological Models;Biopsy;Blood;Blood Volume;BRAF gene;cancer care;cancer cell;cancer genome;Cancer Model;Cancer Patient;cancer risk;cancer therapy;Canis familiaris;Clinical;clinical translation;Collection;Credentialing;Data;Data Correlations;Decision Making;Detection;Development;Diagnosis;Diagnostic;diagnostic tool;Disease;Disease Progression;DNA analysis;DNA Sequence;DNA Sequence Alteration;Early Diagnosis;early screening;Ensure;Epidermal Growth Factor Receptor;Evaluation;Evolution;Exhibits;experience;Frequencies;Future;Genetic;Genomics;Goals;Grant;Hemangiosarcoma;Hematopoiesis;Human;Immunotherapy;improved;in silico;Individual;large cell Diffuse non-Hodgkin's lymphoma;Liquid substance;Longitudinal Studies;Lymphoma;Malignant neoplasm of lung;Malignant Neoplasms;Mast Cell Neoplasm;Methodology;Methods;model development;Modeling;Molecular;Monitor;Mus;Mutation;noninvasive diagnosis;novel;Oncology;Osteosarcoma;Outcome;outcome prediction;patient screening;Patient-Focused Outcomes;Patients;Performance;Peripheral;PIK3CA gene;Plasma;precision medicine;Predictive Value;prevent;Prevention;Procedures;prospective;Radiation;Relapse;Reproducibility;Research;Residual Neoplasm;Resistance;Resources;Risk;Sampling;screening;Sensitivity and Specificity;Site;standard care;Standardization;Techniques;Technology;Testing;Therapeutic Uses;therapy resistant;Time;timeline;TNF receptor-associated factor 3;tool;TP53 gene;Transitional Cell Carcinoma;translation to humans;translational cancer research;treatment planning;treatment response;treatment strategy;tumor;tumor DNA;tumor progression;Variant;variant detection;Veins;Work

PROJECT_TITLE: Leveraging canine spontaneous cancer to optimize the power of blood biopsy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-N(55)R]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative The purpose of our Training Program, in operation since 1971, is to provide research training in critical areas of alcohol studies for scholars and professionals with research backgrounds in public health, epidemiology, psychology, sociology, economics and other social sciences. The proposal describes a coherent and rigorous program of training in the alcohol field that addresses this challenge, offering training particularly in alcohol epidemiology, services, and policy research, all with a disparities focus. Trainees are equipped by their experience to obtain NIH funding and make productive contributions in their careers to the growth of knowledge concerning alcohol use, use disorders and related problems.

PI_NAMEs: KERR, WILLIAM C. (contact)

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TITLE: Graduate Research Training in Alcohol Problems: Alcohol-Related Disparities


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: B cells of the immune system are a leading model for the analysis of gene regulatory networks (GRNs), and variation in the human B cell regulatory genome has been associated with autoimmune diseases and differential vaccine responses. However, there has not been a comprehensive attempt to delineate the cis-regulome of primary human B cells in their resting, activated and terminally differentiated states or to assemble corresponding dynamic GRNs. Based on our recent success in assembling the first comprehensive murine B cell cis-regulome, our inter-disciplinary team is proposing to assemble a human B cell cis-regulome and corresponding dynamic GRNs, and study the consequences of disease-associated non-coding variation in the context of these dynamic GRNs.

PI_NAMEs: DAS, JISHNU ;SINGH, HARINDER  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Address;Antibodies;Antibody Affinity;Antibody Repertoire;ATAC-seq;Autoimmune Diseases;B cell differentiation;B-Lymphocytes;biobank;Biological;Catalogs;Cell Line;cell type;Cells;Cellular biology;Chromatin;Coupled;Coupling;Data;Data Set;Disease;Elements;Enhancers;FAIRE sequencing;functional genomics;Gene Expression Profile;Gene Expression Profiling;gene network;gene regulatory network;Generations;Genes;Genetic Recombination;Genetic Transcription;genetic variant;Genome;genome editing;genome wide association study;Genomic approach;genomic profiles;genomic profiling;genomic variation;Genomics;Health;Hi-C;Human;Human Genome;Human Herpesvirus 4;Immune system;Immune System Diseases;Immunologist;Insulin-Dependent Diabetes Mellitus;Libraries;Light;Link;Linkage Disequilibrium;Machine Learning;machine learning model;Mammalian Cell;Maps;Modeling;Mus;next generation;novel;Output;pathogen;Patients;Plasma Cells;promoter;Proteins;Regulation;Resolution;response;Rest;screening;Signal Induction;Signal Transduction;structural genomics;Structure;success;System;Systemic Lupus Erythematosus;temporal measurement;Testing;Training;transcription factor;Transcriptional Regulation;transcriptome sequencing;Untranslated RNA;vaccine response;Vaccines;Variant

PROJECT_TITLE: Linking genome variation to transcriptional network dynamics in human B cells


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Heart, vascular and respiratory diseases continue to be leading causes of morbidity and mortality in the US, and reflect the complex interactions of environmental and genetic factors that modify the integrated function of proteins, cells, organs and organ systems and thereby, alter disease susceptibility, as well as responsiveness to therapies. Continued progress in precision diagnosis, treatment and prevention strategies for heart, vascular and respiratory diseases requires a mechanistic understanding at the systems level as it relates to the fundamental physiology of health and disease. Our long-standing translational cardiovascular and pulmonary (CVP) program, coupled with outstanding institutional support, provides trainees with opportunities to address modern-era data- driven research projects by delivering a contemporary and collaborative didactic research experience and professional development to train and mentor the next generation of CVP researchers.

PI_NAMEs: KONHILAS, JOHN P (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Cardiovascular system;Research;Training

PROJECT_TITLE: Interdisciplinary Training in Cardiovascular Research


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE This K08 proposal describes the training plan and expertise that the applicant, Dr. Steven Rhodes MD, PhD, will require over the subsequent five years to develop his career as an independent physician scientist investigating tumor and immune system interactions mediating the progression of NF1-associated peripheral nerve sheath tumors. Collectively, these studies will provide key insights regarding dynamic interactions between infiltrating T cell and neoplastic Schwann cells to modulate the tumor progression across various stages of the neurofibroma to MPNST continuum and to evaluate new chemopreventative strategies to prevent the malignant transformation in persons at risk.

PI_NAMEs: RHODES, STEVEN DAVID (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Ablation;Address;Advanced Malignant Neoplasm;Affect;antagonist;Automobile Driving;Benign;cancer predisposition;care burden;career;Cause of Death;CDKN2A gene;Cell Communication;Cell Shape;Cells;Cellular biology;Cessation of life;checkpoint inhibition;Chemoprevention;Clone Cells;CTLA4 gene;density;deprivation;Development;Disease;disease natural history;Doctor of Philosophy;Ecosystem;effective therapy;Embryo;Environment;Evaluation;Event;Evolution;Excision;exhaust;exhaustion;Exhibits;Five-Year Plans;Funding;Genetic Predisposition to Disease;Genetically Engineered Mouse;Heritability;Heterogeneity;Human;hyperactive Ras;Immune;immune cell infiltrate;Immunocompetent;Immunologic Surveillance;Immunologics;Immunooncology;Immunophenotyping;improved;Incidence;Indiana;Individual;Infiltration;insight;Knowledge;Laboratories;Laboratory Research;Macrophage;Malignant - descriptor;Malignant Neoplasms;mast cell;matriculation;Mediating;Medical;medical schools;Mentors;Molecular;mouse model;mutant;Neoplastic Schwann Cell;neurofibroma;Neurofibromatoses;Neurofibromatosis 1;Neurofibrosarcoma;neutralizing antibody;new therapeutic target;NF1 gene;novel;novel strategies;Oncogenic;Oncology;pathogen;Pathogenesis;Patients;pediatric department;Pediatric Hematology;Pediatric Research;Pediatrics;Peripheral Nerve Sheath Neoplasm;Peripheral Nervous System Neoplasms;Persons;Phenotype;Physicians;Play;Plexiform Neurofibroma;Populations at Risk;pre-clinical;premalignant;premature;prevent;Prevention strategy;Prognosis;programs;Proliferating;receptor;Research;Research Personnel;Residencies;Resolution;Resources;response;Role;Sampling;Sarcoma;Schwann Cells;Scientist;Shapes;single-cell RNA sequencing;stemness;Suspensions;Syndrome;T cell infiltration;T-Cell Depletion;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic Intervention;Training;Training Programs;treatment strategy;tumor;Tumor Immunity;tumor initiation;tumor microenvironment;tumor progression;Tumor stage;Tumor Suppressor Proteins;tumor-immune system interactions;tumorigenesis;tumorigenic;United States National Institutes of Health;Universities;Validation;Work

PROJECT_TITLE: T cells in neurofibroma pathogenesis and malignanttransformation

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Genetics;Machine Learning and Artificial Intelligence;Macular Degeneration;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: Newark

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Inherited retinal degenerations are a leading cause of blindness worldwide, and visual impairment is an increasing public health issue, particularly with our aging population. Several types of retinal degeneration, affecting both the young and the old, are associated with variants in the ABCA4 gene. The studies in this proposal seek to bridge the knowledge obtained from clinical genetics of variants in the ABCA4 gene with their corresponding structural and functional consequences at the protein level so that more accurate prognoses and targeted therapies may be developed in the near future; we do this in concert with DEIA activities aimed at promoting diversity in the biomedical workforce.

PI_NAMEs: BISWAS-FISS, ESTHER ELISSA (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: 220kDa rod outer segment rim protein;3-Dimensional;Affect;aging population;American;annotation  system;ATP phosphohydrolase;Awareness;Benchmarking;Benign;Biochemical;bioimaging;Biological Process;Biology;Biomedical Research;Biometry;Blindness;career;Classification;Clinical;Clinical Trials;clinically significant;ClinVar;Communication;Communities;community engagement;community partners;Computational Biology;cone-rod dystrophy;Data;Data Analyses;Data Set;Development;Disease;Doctor of Philosophy;equity, diversity, and inclusion;Fostering;Functional disorder;Future;Genes;Genetic;genetic association;genetic testing;genetic variant;Genotype;Goals;Health;in silico;In Vitro;Individual;Informatics;Inherited;inherited retinal degeneration;Interdisciplinary Study;interest;Joints;Knowledge;Laboratories;Life;Literature;machine learning pipeline;Mediating;Medical Genetics;medical schools;Modeling;Molecular;molecular pathology;Mutation;novel therapeutics;novel virus;Pathogenicity;Patient risk;Patients;Persons;Phenotype;Photoreceptors;precision medicine;preventive intervention;Process;Prognosis;programs;prospective;Protein Biochemistry;protein function;protein structure;Proteins;public database;Public Health;Recombinants;Recycling;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Resources;Retinal Degeneration;Retinal Diseases;retinal stimulation;Rewards;Risk;risk prediction;Sampling;Science;Severity of illness;Speed;Stargardt's disease;Structure;Structure of retinal pigment epithelium;Students;symposium;System;targeted treatment;Testing;tool;Training;training data;training opportunity;Uncertainty;Variant;variant of unknown significance;Virus-like particle;Vision research;visual cycle;Visual impairment;Work

PROJECT_TITLE: Understanding ABCA4 Variants of Unknown Significance Through Computational and Functional Approaches

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-G (56)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_NAME: HENRY FORD HEALTH SYSTEM

PHR: PROJECT NARRATIVE Pancreatic cancer (PDAC) is a deadly malignancy characterized by extensive fibrosis and immune suppression. The complex interplay between tumor cells and their surrounding stroma has not been fully elucidated. Since current therapeutic approaches targeting individual components of the tumor microenvironment have failed to benefit patients, the goals of the project are to: define 1) Slit2- and 2) Slit3- dependent tumor/fibroblast/immune cross talk using genetic mouse model approaches, and 3) elucidate the impact of dual SLIT2/3 deletion in primary human CAFs in vitro on angiogenesis and tumor cell growth.

PI_NAMEs: STEELE, NINA G (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: angiogenesis;Angiogenesis Inhibition;Cancer Etiology;cell growth;Cessation of life;Coculture Techniques;Communication;Complex;Data;effective therapy;Endothelial Cells;Epithelium;experimental study;Fibroblasts;Fibrosis;Genetic;Genetic study;Goals;Human;Immune;Immunosuppression;In Vitro;Individual;Infiltration;Invaded;Malignant neoplasm of pancreas;Malignant Neoplasms;mouse model;Mutate;Neoplasm Metastasis;neoplastic cell;neural;novel;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;Patients;Pharmacology Study;Reaction;receptor;Role;Signal Transduction;Therapeutic;tumor;tumor metabolism;tumor microenvironment;Work

PROJECT_TITLE: Investigating Cellular Communication in the Tumor Microenvironment in Pancreatic Cancer

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative HDACs are a key epigenetic enzymes involved in Alzheimer’s disease (AD). This proposal aims to develop novel HDAC11 selective inhibitors and perform evaluation in AD cells and models.

PI_NAMEs: WANG, CHANGNING  (contact);ZHANG, CAN MARTIN

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: Affinity;Agreement;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease therapeutic;Amyloid beta-42;Amyloid beta-Protein;amyloid pathology;analog;Animal Diseases;Animals;anti-epileptic agents;Autopsy;Binding;Binding Proteins;Biological Assay;Biological Availability;blood-brain barrier penetration;Brain;candidate identification;Cell model;Cells;chemical synthesis;clinical candidate;Clinical Trials;clinically significant;Cognitive deficits;cognitive function;Communities;Data;Dementia;design;Disease;disease model;DNA Sequence;drug development;drug discovery;effective therapy;Enzymes;Epigenetic Process;epigenetic regulation;Evaluation;Family;FDA approved;flexibility;Future;Generations;Genetic;Genome;Goals;HDAC11 gene;HDAC4 gene;Histone Deacetylase;Histone Deacetylase Inhibitor;Human;immune stimulant;improved;In Vitro;in vivo;Inflammatory;Inflammatory Response;inhibitor;Investigational Drugs;Lead;lead candidate;Lipopolysaccharides;Liver;Malignant Neoplasms;Matrix Metalloproteinases;Measures;member;Metabolic;meter;Microglia;Modeling;Modification;Mood stabilizers;mouse model;multidisciplinary;multimodality;Mus;Nervous System Disorder;neurobehavioral test;Neurodegenerative Disorders;neuroinflammation;Neurology;neuropathology;new therapeutic target;novel;Oral;Parasitic Diseases;Pathology;Permeability;Phagocytosis;Pharmaceutical Chemistry;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacological Treatment;Pharmacology;Plasma Proteins;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;preclinical study;prevent;Property;Protein Isoforms;Psychiatry;receptor;Regimen;Reporting;Research;Safety;scaffold;Series;small molecule;small molecule inhibitor;small molecule libraries;Specificity;Structure-Activity Relationship;Testing;Therapeutic;Toxic effect;uptake;Validation

PROJECT_TITLE: New epigenetic inhibitors for Alzheimer's disease treatment

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]