NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hematology;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The proposed research seeks to study the factors associated with development of clonal hematopoiesis of indeterminate potential (CHIP), and racial disparities in associated outcomes, in order to identify individuals at increased risk. With the availability of low cost sequencing techniques, we expect the number of individuals with CHIP to increase in future, and, it will be important to develop appropriate strategies to manage these individuals. Knowledge gained from the proposed study is expected to set the stage for interventions to inform management of CHIP and decrease the risk of associated adverse outcomes such as hematologic malignancies, cardiovascular disease and mortality.

PI_NAMEs: GANGARAJU, RADHIKA  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Address;Adult;adverse outcome;Age;Alcohols;Anemia;Anti-Inflammatory Agents;Area;Atherosclerosis;Behavioral;Bioinformatics;Biological Markers;Biometry;biracial;Black Populations;Black race;Blood;Blood Cells;Blood specimen;Bone Marrow;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;career;career development;Characteristics;Classification;Clinical;Clinical Data;Clonal Evolution;Clonal Expansion;Coagulation Process;cohort;contextual factors;Coronary heart disease;cost;Coupled;cytopenia;deep sequencing;demographics;Development;Development Plans;Diabetes Mellitus;Diet;Disparity;DNA;Dyslipidemias;Enrollment;Environmental Exposure;Environmental Risk Factor;Exercise;exome sequencing;experience;Female;follow-up;Foundations;Frequencies;Funding Mechanisms;Future;Genes;Goals;Grant;Guidelines;Health behavior;Health Disparities Research;Hematologic Neoplasms;Hematological Disease;Hematopoiesis;Hematopoietic stem cells;High Prevalence;high risk;human old age (65+);Hypertension;improved;Income;indexing;Individual;Inflammation;Institution;Intervention;K-Series Research Career Programs;Knowledge;Laboratories;leukemia;Leukopenia;low socioeconomic status;male;Mediating;Mentors;Mentorship;Modeling;Modification;Monitor;mortality;Mutation;Nature;neighborhood disadvantage;Neighborhoods;Obesity;Outcome;Participant;Pathogenesis;Pattern;personalized intervention;pharmacologic;Phenotype;phenotypic data;Physicians;Prevalence;Prevention strategy;programs;prospective;Prospective Studies;Prospective, cohort study;Race;racial difference;racial disparity;racial population;Reasons for Geographic And Racial Differences in Stroke;Recording of previous events;Research;Research Methodology;residence;Resources;Risk;Risk Factors;risk prediction model;Role;Sampling;Scientist;Series;sex;skills;Smoking;sociodemographics;Socioeconomic Status;socioeconomics;Somatic Mutation;statistics;Stress;Stroke;success;targeted sequencing;Techniques;Time;Training;translational scientist;United States

PROJECT_TITLE: Clonal Hematopoiesis in a Biracial Population

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Hematology

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE PHD2 is the central oxygen sensor in the pathway that controls the number of red cells in blood. We are still at an early stage of our understanding of how it works. We propose to study how PHD2 interacts with other proteins in this pathway in order to obtain a detailed understanding of how PHD2 controls red cell mass.

PI_NAMEs: LEE, FRANK S (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Ablation;Address;Alleles;Altitude;Amino Acid Substitution;Anemia;Binding;Blood;C-terminal;Catalytic Domain;Cell Count;Client;Clinical Treatment;Complex;Curiosities;Erythrocyte Indices;Erythrocytes;Erythrocytoses;Erythropoiesis;Event;Foundations;Genes;Heat-Shock Proteins 90;Hematocrit procedure;Hemoglobin;Human;Hydroxylation;Hypoxia;Hypoxia Inducible Factor;Impairment;In Vitro;Individual;insight;interest;kidney cortex;Knock-in;Knock-in Mouse;Left;Link;loss of function mutation;Messenger RNA;Missense Mutation;Modeling;Molecular Chaperones;Mus;Mutation;N-terminal;Output;Oxygen;Pathway interactions;Patients;polypeptide;prevent;Procollagen-Proline Dioxygenase;protein folding;Protein Isoforms;Proteins;recruit;Red Blood Cell Count;Red Cell Mass result;Regulation;Renal Interstitial Cell;Reporting;Research;Ribosomes;Role;sensor;Serum;Source;Tacrolimus Binding Proteins;Testing;Time;Tissues;transcription factor;Translations;Variant;Work;Zinc Fingers

PROJECT_TITLE: Control of Erythropoiesis by the Oxygen Sensor PHD2

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Newark

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE The formation of sperm and eggs with the “wrong” number of chromosomes is a key contributing factor to infertility, miscarriages, and birth defects in humans. The proposed project seeks to identify and characterize the mechanisms that contribute to sex-specific chromosome structure and chromosome separation in sperm vs. eggs. The completion of this project will advance our understanding of how the disruption of components that determine chromosome structure and separation contributes to both male and female infertility and to the development of birth defects.

PI_NAMEs: JARAMILLO-LAMBERT, AIMEE  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Alleles;Animal Model;Biochemical;Caenorhabditis elegans;Candidate Disease Gene;Cell division;Cells;Chromosome Segregation;Chromosome Structures;Chromosomes;Congenital Abnormality;Development;Diploidy;DNA;ds-DNA;egg;Embryo;Embryonic Development;Ensure;Enzymes;Female infertility;Fertilization;Generations;Genes;Genetic Recombination;Genetic Techniques;Genetic Transcription;Germ Cells;Goals;Haploidy;Human;in vivo evaluation;Infertility;Male Infertility;Meiosis;Mitosis;Molecular;Morphology;mutant;Mutation;Mutation Analysis;novel;Oogenesis;Phenotype;Play;Process;programs;Proteins;Regulation;Research;Role;segregation;sex;Sex Differences;sex linked trait;sexual dimorphism;Specificity;sperm cell;Spermatogenesis;Spontaneous abortion;Synaptonemal Complex;System;Time;Topoisomerase II;tyrosyl-DNA phosphodiesterase;Work

PROJECT_TITLE: New roles for Topoisomerase II in meiosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Cerebrovascular;Clinical Research;Kidney Disease;Neurosciences

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Acute kidney injury is a common and serious complication among hospitalized patients and confers substantial risks of end-stage kidney disease and death. While dialytic support for severe acute kidney injury can be life- sustaining, outcomes are poor and methods to guide a safe rate of fluid removal during hemodialysis are inadequate. The objective of this work is to leverage noninvasive devices to simultaneously quantify the systemic and tissue hemodynamic response to fluid removal throughout hemodialysis to better understand mechanisms underlying adverse consequences of hemodialysis and advance the development of more precise approaches to the delivery of renal replacement therapy.

PI_NAMEs: BROTMAN, CHRISTINA HAO WANG (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Achievement;acute care;Acute Renal Failure with Renal Papillary Necrosis;Advanced Development;Adverse effects;adverse outcome;Affect;Age;Attention;Award;Bedside Testings;Blood Pressure Monitors;Blood Vessels;Cardiac Output;career development;cerebral autoregulation;cerebral oxygenation;Cerebrovascular Circulation;Cerebrum;Cessation of life;Chronic Kidney Failure;Clinical;clinical epidemiology;cognitive function;cognitive testing;cohort;Cohort Studies;comorbidity;Complex;Complication;Critical Illness;Data;Data Set;Degree program;design;Development;Development Plans;Devices;Dialysis procedure;Diffuse;End stage renal failure;Epidemiologic Methods;Epidemiology;Equilibrium;Excision;experience;Fluid overload;Functional disorder;Funding;Goals;heart function;Hematocrit procedure;Hemodialysis;hemodynamics;Hospitalization;Hybrids;hypoperfusion;Hypotension;Impairment;improved;Inpatients;Institution;Intensive Care Units;interstitial;Intervention Studies;Investigation;Ischemia;Kidney;Kidney Diseases;Life;Linear Regressions;Link;Liquid substance;longitudinal analysis;Maintenance;Master of Science;Measurement;Measures;Mediating;Mediation;Mediator;Mentors;Methodology;Methods;Modality;Modeling;Monitor;multidimensional data;multidisciplinary;multiple chronic conditions;Myocardial Stunning;novel strategies;Observational Study;Operative Surgical Procedures;Optics;Organ;Outcome;Outcome Study;Outpatients;Oxygen;Participant;Patient-Focused Outcomes;Patients;Perfusion;personalized approach;Persons;Physiology;Plasma;Population;Positioning Attribute;Postoperative Period;Predisposition;pressure;prevent;programs;prospective;Prospective cohort;Prospective Studies;Prospective, cohort study;Reaction Time;Recovery;Renal dialysis;Renal Replacement Therapy;Research Design;Research Personnel;response;Risk;skills;spatiotemporal;Spectrum Analysis;Statistical Models;System;Techniques;Technology;Testing;Tissues;Trail Making Test;Training;treatment effect;Treatment Factor;Ultrafiltration;Venous;vigilance;Work

PROJECT_TITLE: Macrovascular and Microvascular Response to Fluid Removal during Hemodialysis for Acute Kidney Injury

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: DETROIT

ORG_NAME: HENRY FORD HEALTH SYSTEM

ORG_STATE: MI

PHR: Project Narrative Adequate language input is required for typical language development, however, NICU infants are at particularly high risk for experiencing a language deprived environment early in development and may spend weeks-to- many-months of a critical developmental period in this setting. Importantly, we know that the language environment in the NICU matters: the quantity and quality of language input NICU infants receive has been associated with positive short-and-long-term outcomes (e.g., alertness, attentiveness, verbalizations, vocalizations, language). In this proposal, the applicant will engage in mentoring, training, and research activities to leverage implementation science frameworks, health equity constructs, and psychological and organizational theories to refine a proposed causal model of parent and clinician intentions to use IDS with NICU infants in preparation for a Hybrid Type 1 (effectiveness-implementation) trial that emphasizes intervention accessibility.

PI_NAMEs: MAYE, MELISSA  (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Adult;Affect;Agreement;alertness;Behavior;Caring;causal model;Child;Child Development;Climate;Clinical Trials;Cognitive;critical developmental period;Data;Development;disorder prevention;effectiveness testing;effectiveness/implementation trial;Environment;Environmental Risk Factor;Equity;experience;Face;falls;Frequencies;Gestational Age;Goals;Health;health care disparity;health care service;health disparity;health equity;Health Services Research;Hearing;high risk;Hospitalization;hybrid type 1 trial;Hybrids;implementation framework;implementation research;implementation science;implementation/effectiveness;Individual;Infant;Infant Care;Infant Development;infant outcome;innovation;Intervention;Interview;Language;Language Development;language outcome;lexical;Life;Long-Term Effects;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Modeling;National Institute of Child Health and Human Development;Neonatal Intensive Care Units;Nurses;Occupational Therapist;Outcome;Parents;Pattern;phonology;physical conditioning;Physicians;pilot test;Premature Infant;Preparation;Professional Role;Provider;provider factors;psychologic;Psychological Theory;Public Health;Recovery;Research;Research Activity;Resistance;Role;routine care;routine practice;Sales;simulation;Site;skills;Speech;Structure;Surveys;theories;therapy design;Time;Training;Training Activity;United States;uptake;verbal;Visit;vocalization;Weight;Work

PROJECT_TITLE: Small Things First: Leveraging Implementation Science to Increase Access to Infant Directed Speech for ALL Infants in Neonatal Intensive Care Units

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Human Genome;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Although abdominal aortic aneurysm (AAA) is a primary medical concern due to the increasing prevalence in older people and a very high mortality rate upon rupture, there are no effective pharmaceutical treatments for AAA to date. We propose to define the protective roles and underlying molecular mechanisms of vascular smooth muscle cells specific BAF60c in the development of AAA, which will set the basis to target BAF60c or its downstream factors for AAA treatment.

PI_NAMEs: ZHANG, JIFENG  (contact)

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: abdominal aorta;Abdominal Aortic Aneurysm;Address;Affect;Age;Aneurysm;Angiotensin II;Aorta;Apoptosis;Atherosclerosis;Attention;Attenuated;Automobile Driving;Blood Vessels;brahma;Cardiovascular system;Catalytic Domain;Cathepsins;Cell Separation;Cells;Cellular biology;ChIP-seq;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;Co-Immunoprecipitations;Complex;Contractile Proteins;Data;Death Rate;Development;Diabetes Mellitus;differential expression;DNA;Elastases;Eligibility Determination;Energy Metabolism;Environment;Epigenetic Process;Extracellular Matrix Degradation;Family;Family member;Functional disorder;gain of function;Gene Expression;Genes;genetic association;genomic locus;granulocyte;Heart;high risk;Homeostasis;Human;Hyperlipidemia;Hypertension;In Vitro;in vivo;in vivo Model;Incidence;Individual;Inflammation;Inflammatory;insight;knock-down;Knock-in Mouse;Knock-out;Knockout Mice;Ligands;Link;Lipids;loss of function;LoxP-flanked allele;male;Maps;Medial;Mediating;Medical;member;Metabolic;MMP9 gene;Molecular;mortality risk;mouse model;Mus;novel;novel therapeutics;Older Population;Operative Surgical Procedures;Outcome;p65;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Phenotype;Play;Prevalence;prevent;Primary Prevention;Process;promoter;Promoter Regions;protein expression;Receptor Signaling;recruit;Regulation;repaired;Reporting;response;Risk Factors;Role;Rupture;Sampling;Scheme;sex;Sex Differences;single-cell RNA sequencing;Smoking;Smooth Muscle Myocytes;Stains;Stimulus;Sucrose;Therapeutic;therapeutic target;Thoracic Aortic Aneurysm;Tissue Sample;Tissues;transcription factor;transcriptome sequencing;Transducers;Transgenic Mice;Translating;vascular inflammation;Vascular Smooth Muscle;Viral Vector;Work

PROJECT_TITLE: BAF60c and abdominal aortic aneurysm

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Nutrition

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: NARRATIVE One of the great challenges of modern medicine is to understand how environmental factors, such as diet, contribute to the increasing incidence of inflammatory and autoimmune diseases. We have recently discovered that the food colorant Red 40, the most abundant food colorant in the world, may be an important factor contributing to this phenomenon. Under normal conditions, consumption of this product does not induce disease, but if it is coupled to abnormal expression of the immune hormone IL-23 in mice, it can lead to development of intestinal inflammation that has many similarities with human IBD. In this application we describe a research project to study how one environmental factor (the food colorant Red 40) interacts with IL- 23, intestinal bacteria, and immune cells to cause intestinal inflammation.

PI_NAMEs: LIRA, SERGIO A. (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Affect;Animals;Antigens;Autoimmune Diseases;Bacteria;Beverages;Binding;Biology;Candy;CD4 Positive T Lymphocytes;Cecum;Cells;Chemicals;Cherry - dietary;Child;Citrobacter rodentium;Clinical;Colitis;Colon;Consumption;Cosmetics;Coupled;cytokine;Dairying;Data;Dendritic Cells;Developing Countries;Development;Diet;Diet Habits;dietary;Disease;Disease remission;Environmental Risk Factor;Etiology;experimental study;Exposure to;Flare;Food;Food Coloring Agents;Generations;Genes;Genetic;Genetic study;gut inflammation;Haptens;Hormones;Human;Hydration status;Immune;Immune response;Immune system;In Vitro;Incidence;Incubated;Individual;Infection;Inflammatory;Inflammatory Bowel Diseases;Injections;interest;interleukin-23;Intestines;Life;Link;Medicine;microbiota;Modern Medicine;Mus;Myeloid Cells;Naphthols;Pharmaceutical Preparations;Prevention;Production;Property;Proteins;Rectum;Regulatory T-Lymphocyte;Research Project Grants;response;Role;Signal Pathway;soft drink;T-Lymphocyte;Testing;Tissues;Wild Type Mouse;Work

PROJECT_TITLE: Mechanisms associated with flares and remission in colitis

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: ITHACA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative Enhancing the resolution of the human genome has been one of the major drivers of the advances in biomedical sciences, which lead to the discovery of important factors of gene expression and dysregulations in diseases. My research program seeks to precisely locate, where on the genome and where in the cell, the control mechanisms of gene expression take place using high resolution RNA analysis. We will further apply these high-resolution maps of the RNA regulation in human immune cells from metabolic diseases and cancer immunotherapy aspects, which will lead to the discovery of novel target genes and disease mechanisms.

PI_NAMEs: KWAK, HOJOONG  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;cancer immunotherapy;Cells;Chromatin;Chromosome Mapping;cost efficient;Cytoplasmic Granules;Disease;DNA Sequence Alteration;Elements;Enhancers;exhaustion;Foundations;Gene Expression;Genes;Genetic Enhancer Element;Genetic Transcription;Genetic Variation;Genome;Genomics;High-Throughput RNA Sequencing;Human;human disease;Human Genome;Immune;immune activation;improved;innovation;life span;Link;Maps;Membrane;Metabolic Diseases;Methods;Mission;Modification;Molecular;new therapeutic target;novel;Organelles;peripheral blood;Phase;Poly(A) Tail;precision medicine;Precision Run-On Sequencing;Process;programs;Regulation;Research;Resolution;RNA;RNA analysis;RNA Processing;Running;Science;Site;spatiotemporal;Specificity;stress granule;Tail;temporal measurement;trafficking;transcriptome sequencing;Variant

PROJECT_TITLE: High Resolution Functional Maps of Enhancer RNA and Subcellular RNA Granules in Human Immune Cells


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Atherosclerosis;Chronic Obstructive Pulmonary Disease;Climate-Related Exposures and Conditions;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Chronic lung diseases are among the top contributors to mortality in the United States and have previously been linked to air pollution. The proposed research will leverage advances in machine learning to develop novel statistical methods for the analysis of complex existing data on air pollution and lung disease progression over time. By combining his expertise in causal inference and machine learning with newly obtained training in air pollution science and environmental determinants of disease, Dr. Malinsky will advance the state of environmental data science and establish himself as an independent investigator in the intersection of biostatistics, machine learning, epidemiology, and environmental science.

PI_NAMEs: MALINSKY, DANIEL  (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Address;Air;Air Pollutants;Air Pollution;Applications Grants;Area;Award;Behavioral;Biometry;Biostatistical Methods;Black race;Body mass index;career;career development;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Climate;cohort;Complement;Complex;computer science;Computer software;Data;Data Science;Data Sources;Dependence;design;Disease;Disease Outcome;Disease Progression;Dose;Environmental Epidemiology;Environmental Health;Environmental Science;epidemiologic data;Epidemiologist;Epidemiology;Ethnic Origin;Etiology;Exposure to;fine particles;flexibility;Funding;Goals;Grant;Health;health determinants;Heterogeneity;Hispanic;Image;Individual;Instruction;intervention effect;K-Series Research Career Programs;Knowledge;Link;Literature;Longitudinal cohort;Longitudinal Studies;Longitudinal, observational study;Lung Diseases;lung health;Machine Learning;machine learning prediction;Measurement;Measures;Mentors;Metals;Methodology;Methods;Modeling;mortality;Multi-Ethnic Study of Atherosclerosis;Nitrogen Oxides;Not Hispanic or Latino;novel;open source;Outcome;Ozone;Particulate Matter;Policies;Policy Analysis;pollutant;Pollution;Probability;Pulmonary Emphysema;pulmonary function;Race;Research;Research Design;Research Personnel;respiratory;response;Risk;Science;semiparametric;sex;Shapes;Site;social;Statistical Methods;Statistical Models;statistics;Structural Models;Supervision;Techniques;Time;tool;Training;Uncertainty;United States;Variant;Weight;X-Ray Computed Tomography

PROJECT_TITLE: Flexible causal inference methods for estimating longitudinal effects of air pollution on chronic lung disease


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: College Station

ORG_DEPT: ZOOLOGY

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

ORG_STATE: TX

PHR: Aedes aegypti is the main vector of dengue, yellow fever and chikungunya viruses, and is a model system for studies of other mosquitoes that vector arboviruses. Gene drive strategies to introduce pathogen resistance genes into wild mosquito populations represent a powerful new control strategy, but no means of safely testing them in the wild exists. Our proposal seeks a validate a novel self-elimination system in the dengue mosquito that is able to remove itself autonomously from the target population after successful invasion, paving the way to safely test this technology in future field trials.

PI_NAMEs: ADELMAN, ZACH N. (contact);MYLES, KEVIN M

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Aedes;Arboviruses;Arthropods;Behavior;Biological Models;Biology;Chikungunya virus;combat;Communities;CRISPR gene drive;CRISPR/Cas technology;Culicidae;Data;Dengue;density;Development;Direct Repeats;Disease Vectors;DNA;DNA Repair;Drosophila genus;Drosophila melanogaster;ds-DNA;Ecosystem;Effectiveness;Environment;Eukaryota;Excision;expectation;fly;Funding;Future;gene drive system;Genes;genetic element;Genetic Markers;Genetic Models;Germ Lines;hazard;Health;Human;Infrastructure;innovation;International;Intervention;Invaded;Length;Longevity;Malaria;malaria transmission;Measures;model organism;Modeling;Mosquito Control;Natural Resistance;Nature;novel;nuclease;pathogen;Population;Process;repaired;Resistance;resistance allele;resistance gene;restoration;safety testing;Series;simulation;Site;System;Tail;Target Populations;targeted nucleases;Technology;Testing;Time;trait;Transgenes;Transgenic Organisms;vector;vector mosquito;Yellow Fever

PROJECT_TITLE: Self-eliminating strategy to control gene drive

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative There is an urgent need to improve our understanding of the mechanisms underlying effective mucosal wound closure and develop new therapeutic strategies for mucosal wound healing. This proposal will advance our understanding of the role of the CD74 signaling pathway in intestinal epithelial repair and mucosal healing. The work is relevant to public health as the information gained may ultimately lead to effective treatments to heal the mucosa.

PI_NAMEs: MOONAH, SHANNON  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Address;Affect;Agonist;American;Animal Model;Binding;Biological;Biology;Biomedical Engineering;cell regeneration;chemokine receptor;chemotherapy;Clinical;clinical remission;Clinical Trials;CXCR4 gene;CXCR4 Receptors;cytokine;Data;Defect;design;Development;effective therapy;Environment;Epithelial Cell Proliferation;Epithelial Cells;epithelial repair;epithelial wound;Epithelium;epithelium regeneration;Excision;experience;Foundations;Gene Expression;gene function;Genetic Polymorphism;genetic variant;Genetic Variation;Goals;healing;Human;Human Genetics;human migration;Immunology;improved;In Vitro;in vivo;Incidence;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injury;innovation;Innovative Therapy;interleukin-22;Interleukin-8B Receptor;intestinal epithelium;Intestinal Mucosa;Intestines;Investigation;Ischemia;Knowledge;Laboratories;Link;Mechanics;Medical;Migration Inhibitory Factor;Modeling;Mucous Membrane;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Outcome;Pathway interactions;patient subsets;prevent;Probability;promoter;Promoter Regions;Property;Public Health;Publications;Publishing;Radiation;receptor;receptor expression;Recovery;Regenerative Medicine;repaired;Research;Research Personnel;response to injury;Role;seal;Signal Pathway;Signal Transduction;Single Nucleotide Polymorphism;STAT3 gene;success;Surface;Techniques;tool;transcription factor;Trauma;Work;wound;wound closure;wound healing

PROJECT_TITLE: CD74 and Wound Healing

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Mental Health;Neurosciences;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: HENNEPIN HEALTHCARE RESEARCH INSTITUTE

ORG_STATE: MN

PHR: PROJECT NARRATIVE Although nicotine is the main addictive chemical in tobacco products, other chemicals in these products may also contribute to tobacco use. This study will examine whether the greater abuse liability of cigarettes compared to non-combusted products (for example, electronic cigarettes) reflects the presence of other chemicals in cigarette smoke and their neurobiological effects. These studies will help understand how chemicals other than nicotine contribute to tobacco addiction and might suggest ways to tailor medications to treat addiction to different classes of tobacco products.

PI_NAMEs: HARRIS, ANDREW CHARLES;LESAGE, MARK G (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: abuse liability;addiction;Affinity;analog;animal data;Animals;Area;Attenuated;Behavioral;Behavioral Model;Binding;Biological Assay;Brain;Chemicals;Cigarette;cigarette smoke;comparative;Development;Dopamine;Dose;Drug Kinetics;e-cigarette aerosols;Elasticity;Electronic cigarette;Exhibits;Exposure to;Formulation;FOS gene;Gases;Human;In Vitro;in vivo;Liquid substance;Measures;Mediating;Methods;monoamine;Monoamine Oxidase;Monoamine Oxidase Inhibitors;neural;neurobehavioral;neurobiological mechanism;Neurobiology;Nicotine;nicotine replacement;Nicotinic Receptors;novel;Nucleus Accumbens;Outcome;Particulate;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Phase;pre-clinical;Prevention;Procedures;Psychological reinforcement;receptor;Research;Self Administration;Self Stimulation;Serotonin;Smokeless Tobacco;Tobacco;Tobacco Dependence;tobacco products;Tobacco use;volatile organic compound;Water;Work

PROJECT_TITLE: Comparative neurobehavioral pharmacology of combusted and non-combusted tobacco products

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: AG

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: PROJECT NARRATIVE The Massachusetts AI and Technology Center for Connected Care in Aging and Alzheimer's Disease (MAITC) seeks to develop and validate health monitoring devices and artificial intelligence technologies to support healthy aging and Alzheimer's Disease care. The MAITC will play an integral role in eliciting needs from patients, caregivers, and clinicians and supporting research projects aimed at developing new and innovative AI-enhanced technologies to address these needs.

PI_NAMEs: CHOUDHRY, NITEESH K;GANESAN, DEEPAK  (contact)

PROGRAM_OFFICER_NAME: BHATTACHARYYA, PARTHA

PROJECT_TERMS: Acceleration;Address;Adoption;Age;Aging;algorithmic bias;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease patient;Alzheimer's disease related dementia;American;Artificial Intelligence;Artificial Intelligence enhanced;Behavioral;Brain;Businesses;Capital;Caregivers;Caring;Chronic Disease;clinical decision support;cohort;commercialization;Communities;Community Practice;computer scientist;connected care;course module;Data;dementia care;design;Development;Directories;Ecosystem;Educational workshop;Engineering;Enhancement Technology;Ensure;Event;Fostering;General Hospitals;Goals;Grant;Health;Health Technology;healthy aging;Home;Home Care Services;Hospitals;Human;improved;Incubated;Individual;Industry;innovation;Interdisciplinary Study;interest;Intervention;Journals;Knowledge;knowledge base;Massachusetts;Medical;Mentors;Monitor;monitoring device;multidisciplinary;Needs Assessment;Nurses;older adult;online course;Outcome;Output;Patient Care;Patients;Pilot Projects;Play;Policy Maker;Prevalence;Process;Process Assessment;prototype;remote delivery;Research;Research Personnel;Research Project Grants;Research Support;Role;rural area;Scientist;Series;Services;Site;symposium;Technology;Technology Assessment;technology development;technology validation;Testing;Time;Training;Translating;Translations;Universities;urban area;usability;Validation;webinar;Woman


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

PI_NAMEs: GANESAN, DEEPAK  (contact)

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Area;Artificial Intelligence enhanced;Biological Sciences;Boston;Capital;Caring;Clinical Research;Communication;Communities;connected care;Consultations;dementia care;Development;Devices;Enhancement Technology;Ensure;experience;feasibility testing;Financial Support;Fostering;General Hospitals;Goals;healthy aging;Home;Hospitals;Industry;Infrastructure;innovative technologies;Institution;Interdisciplinary Study;interest;Laboratory Research;Leadership;Massachusetts;meetings;member;Mentors;multidisciplinary;Needs Assessment;Outcome;Patient Care;Pilot Projects;Process;Program Research Project Grants;programs;Recommendation;Reporting;Research;Research Personnel;Resources;Services;Site;Structure;synergism;Technology;Training;Universities;Vision;Woman;Work

PROJECT_TITLE: Massachusetts AI and Technology Center for Connected Care in Aging and Alzheimer's Disease (MAITC): Administrative Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: OXFORD

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY OF OXFORD

ORG_ZIPCODE: OX1 2JD

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will yield a better understanding of risk in autism and thus will lead to improved methods for prevention and treatment. By our exploration of de novo and transmitted variation, it is also relevant to the NIH mission and to the IACC recommendations around identifying genetic risk in ASD.

PI_NAMEs: SANDERS, STEPHAN  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Acceleration;Adult;Affect;analytical method;ANK2 gene;autism spectrum disorder;autism symptoms;Brain Diseases;cell type;Clinical;cohort;Copy Number Polymorphism;Data;Development;developmental disease;Diagnosis;Disease;disorder risk;exome;Family;First Pregnancy Trimester;Foundations;functional genomics;gain of function;gene discovery;General Population;Genes;Genetic;genetic architecture;Genetic Risk;Genetic Variation;genomic data;Goals;Heterogeneity;improved;Individual;Inherited;innovation;insertion/deletion mutation;insight;International;Knowledge;Learning;Link;loss of function;Mental disorders;Methods;Mission;Mutation;Neurodevelopmental Disorder;neuropsychiatric disorder;novel;novel therapeutics;Nucleotides;Outcome;Pathogenesis;Pathway interactions;Pattern;Play;Population;population based;Prevention;Process;Public Health;rare variant;Recommendation;repetitive behavior;Research;Research Project Grants;Resources;RFX3;Risk;risk variant;Role;Sampling;Sequence Analysis;sex;Signal Transduction;Site;social deficits;Source;Statistical Methods;Symptoms;therapeutic target;Trans-Omics for Precision Medicine;transmission process;United States National Institutes of Health;Variant;whole genome

PROJECT_TITLE: 4/4 - The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(60)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Acceleration;Aging;aging and technology;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Artificial Intelligence enhanced;Awareness;Caregivers;Collection;Communities;Community Practice;connected care;Data;design;Development;Enhancement Technology;Ensure;Family;Family member;Focus Groups;Funding;Future;Goals;healthy aging;human centered design;Individual;Industry;informal caregiver;insight;Knowledge;Massachusetts;Mentors;Methodology;Methods;Needs Assessment;new technology;older adult;Outcome;Participant;Patients;Perception;Pilot Projects;Policies;Policy Maker;Preparation;Process;Process Assessment;Qualifying;Research;Research Personnel;Research Project Grants;Resources;Scientific Advances and Accomplishments;Technology;Thinking;usability;Work

PROJECT_TITLE: Massachusetts AI and Technology Center for Connected Care in Aging and Alzheimer's Disease (MAITC): Stakeholder Engagement Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative The proposed project will assess long-term changes to health/lifestyle, advanced planning, and research engagement that Black and White patients with Amnestic Mild Cognitive Impairment (aMCI) make following disclosure of positron emission tomography-based amyloid and tau burden and associated risk of conversion to Dementia-Alzheimer’s Type. Healthcare access will be explored as potential barrier to or facilitator of behavior change. The project therefore addresses a critical ethical and practical challenge facing all AD researchers by determining whether, in the absence of validated treatments for DAT, biomarker disclosure itself may result in adaptive behavior change in patients from diverse racial backgrounds.

PI_NAMEs: RAHMAN-FILIPIAK, ANNALISE  (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Adaptive Behaviors;Address;Aging;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;amnestic mild cognitive impairment;Amyloid;Attenuated;Behavior;behavior change;Behavioral;Bioethics;Biological Markers;biomarker identification;biomarker validation;biopsychosocial;Black Populations;Black race;career;Clinical;Cognition;Cognitive;Cognitive aging;cognitive benefits;cohort;Complex;Consensus;contextual factors;Data;Dementia;dementia risk;Detection;Development;Diagnosis;Diagnostic;Disclosure;Disparity;Early Diagnosis;Education;Enrollment;Ethics;ethnic disparity;ethnic diversity;Etiology;Evaluation;experience;Face;Faculty;Feedback;Foundations;Funding;Future;Gerontology;Goals;Health;health assessment;Health behavior;Health behavior change;Health Benefit;health care availability;Health Care Costs;health determinants;Health Disparities Research;health disparity;Image;Individual;interest;Intervention;Interview;Knowledge;Life Style;Link;Literature;Longitudinal cohort;Longitudinal Studies;Low income;Measurement;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Michigan;Minority;Neurologic;Neuropsychology;novel;older adult;Outcome;Parents;Participant;Patients;Population;Positron-Emission Tomography;predictive marker;Prevalence;Principal Investigator;protein biomarkers;Protocols documentation;psychologic;Public Health;Race;racial difference;racial disparity;racial diversity;racial population;Randomized;Reaction;recruit;Research;Research Methodology;Research Personnel;Risk;Safety;Sampling;Scientific Advances and Accomplishments;skills;social determinants;social health determinants;socioeconomics;Source;standard of care;tau Proteins;Techniques;Therapeutic;Therapeutic Effect;Time;timeline;Training;United States National Institutes of Health;Universities;Validation;Visit;Work

PROJECT_TITLE: Behavioral Change Following Culturally-Informed Biomarker Disclosure in Alzheimer’s Disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PROJECT_TERMS: Acceleration;Address;Adoption;Affect;Aging;aging and technology;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Artificial Intelligence enhanced;Awareness;Caregivers;Caring;clinical translation;Collaborations;Collection;Communities;Community Developments;connected care;course module;Development;Education;Educational workshop;Enhancement Technology;Ensure;Event;experience;Generations;healthy aging;Individual;industry partner;innovation;innovative technologies;interest;Investments;Massachusetts;Medical;Mentors;multidisciplinary;new technology;older adult;online community;online course;Outcome;Patients;Pilot Projects;Play;Policy Maker;Process;programs;Research;research and development;Research Personnel;Research Project Grants;Role;symposium;Technology;Technology Assessment;technology development;Training;Training and Education;Validation;Work

PROJECT_TITLE: Massachusetts AI and Technology Center for Connected Care in Aging and Alzheimer's Disease (MAITC): Technology ID & Training Core


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Immunization;Infectious Diseases;Neurosciences;Prevention;Substance Misuse;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Despite the success of standard antiretroviral therapy, the need for an HIV cure remains compelling, both to improve the lives of people living with HIV and to bring about the end of the pandemic. The “REACH: Research Enterprise to Advance a Cure for HIV” Martin Delaney Collaboratory comprehensive scientific plan aims to uncover mechanisms driving HIV persistence, including intrinsic resistance to cellular-mediated killing, to guide the development of novel combination approaches that can harness cellular immune responses to achieve durable remission and eradication of HIV reservoirs.

PI_NAMEs: CASKEY, MARINA ;JONES, R. BRAD  (contact)

PROGRAM_OFFICER_NAME: BRIDGES, SANDRA H

PROJECT_TERMS: Address;Adherence;African;Aftercare;Antibody Therapy;antiretroviral therapy;Automobile Driving;Back;Basic Science;Biological Products;Bone Marrow Transplantation;Categories;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Immunity;Chronic;Clinic;Clinical;collaboratory;community engagement;community partners;community partnership;comorbidity;Cytolysis;design;Development;Disease remission;Evaluation;experience;flexibility;high risk;HIV;Humoral Immunities;Immune;Immune response;improved;Individual;industry partner;Infection;insight;Integration Host Factors;integration site;Macrophage;Mediating;Natural Killer Cells;neutralizing antibody;next generation;nonhuman primate;novel;pandemic disease;Persons;Pharmaceutical Preparations;Population;Population Heterogeneity;Positioning Attribute;pre-clinical;Predisposition;prevent;Procedures;programs;psychosocial;Recording of previous events;Research;Research Personnel;Resistance;response;Role;social stigma;Source;success;System;T cell response;T-Lymphocyte;Translating;translational pipeline;Viral;viral rebound;Virus;Virus Latency;Woman;Work


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Genetics;Kidney Disease;Prevention;Tobacco;Tobacco Smoke and Health

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE  Humans are frequently exposed to many hazardous chemicals in the environment, tobacco, and diet, some of which damage DNA and can lead to the development of cancer. Our mass spectrometry and software technology are long sought tools that will identify how multiple chemical agents link to DNA and will provide clues to the etiology of cancers for which environmental causes are suspected.

PI_NAMEs: BALBO, SILVIA ;TURESKY, ROBERT J. (contact);WEIGHT, CHRISTOPHER JOHN

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: adduct;Aflatoxins;Alcohols;Algorithms;analytical tool;Applications Grants;Aristolochic Acids;Asia;automated algorithm;automated analysis;Automation;Bioinformatics;bioinformatics tool;Biological Assay;biomarker discovery;Cancer Etiology;Cancer Patient;cancer risk;Carcinogens;Categories;cell type;Characteristics;Chemical Agents;Chemical Exposure;chemical genetics;Chemicals;cohort;Complex;Computer software;cooking;Data;Data Analyses;Databases;Detection;Developed Countries;Development;Diet;DNA;DNA Adducts;DNA analysis;DNA Damage;DNA Repair;Environment;environmental mutagens;environmental tobacco smoke;Enzymes;epidemiology study;Etiology;Europe;Exposure to;Gender;Genes;Genetic Polymorphism;Genome;Goals;Hazardous Chemicals;Herbal Medicine;Human;Human Genome;human tissue;improved;Individual;Induced Mutation;Inflammation;informatics tool;Investigation;Kidney;kidney biopsy;Leukocytes;lifestyle factors;Link;Liquid Chromatography;Malignant neoplasm of liver;Malignant Neoplasms;Mammary gland;Mass Fragmentography;Mass Spectrum Analysis;Measurement;Measures;Meat;Medicine;metabolomics;Methods;Molecular Analysis;Monitor;Mutation;nano;non-smoker;novel;Organ;Oxidative Stress Induction;Pattern;Pesticides;Pollution;Population;Predisposition;prevent;Process;Prostate;Proteomics;Public Health;Rattus;Reactive Oxygen Species;Renal Carcinoma;Renal Cell Carcinoma;Research Design;Resolution;Risk Assessment;Risk Factors;Rodent;Role;Sampling;Scanning;Smoker;software development;Software Tools;Specificity;Specimen;Structure;Techniques;Technology;Testing;Tissues;Tobacco;tobacco exposure;Tobacco smoke;tool;toxicant;United States;Xenobiotic Metabolism

PROJECT_TITLE: Kidney DNA Adductomics

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Clinical Research;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease related dementia;analytical method;Artificial Intelligence enhanced;Biological Sciences;Brain;Caring;Clinical;clinical translation;cohort;Cohort Studies;connected care;Consultations;Data Analytics;Databases;design verification;Enhancement Technology;feasibility testing;healthy aging;Home;Hospitals;improved;interest;knowledge base;knowledgebase;Longitudinal cohort study;Massachusetts;Monitor;older adult;older patient;Older Population;Patient Recruitments;Pilot Projects;Process;programs;recruit;Research;Research Design;Research Personnel;Research Project Grants;research to practice;Resources;rural setting;Services;success;Technology;technology validation;Training;Translations;urban setting;usability;Validation;Woman

PROJECT_TITLE: Massachusetts AI and Technology Center for Connected Care in Aging and Alzheimer's Disease (MAITC): Clinical Translation and Validation Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: Project Narrative Millions of Americans suffer from deficits in reward-seeking in the context of psychiatric disorders, such as major depressive disorder, schizophrenia, and substance use disorders. Stress can both exacerbate these disorders and directly cause reward-seeking deficits. In this project, we will use recent discoveries about inhibitory cells within a key reward circuit in the brain (ventral tegmental area to nucleus accumbens) to uncover the mechanism by which stress causes reward-seeking deficits and to discover ways to prevent and reverse these negative effects of stress.

PI_NAMEs: HARRIS, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Acute;acute stress;Affect;American;Association Learning;Aversive Stimulus;awake;Brain;Calcium;cell type;Cells;Chronic;Chronic stress;Communication;Complex;Consumption;Cues;Data;Disease;Dopamine;dopaminergic neuron;Electrophysiology (science);endophenotype;Ethology;Etiology;expectation;Functional disorder;gamma-Aminobutyric Acid;Gene Expression;Genetic;Goals;Halorhodopsins;hedonic;Impairment;in vivo;Induced Neurons;Learning;Light;Link;Major Depressive Disorder;Measures;Mediating;Mental disorders;Motivation;Mus;neural;neural circuit;neuronal circuit disruption;Neurons;novel;Nucleus Accumbens;Opsin;optogenetics;Outcome;Pathologic;Pathology;Pathway interactions;Periodicity;Play;Predisposition;preference;prevent;Process;Research;Research Personnel;resilience;response;reward anticipation;reward circuitry;reward processing;Rewards;Role;Schizophrenia;Series;Site;Stress;Stressful Event;Substance Use Disorder;Taste Perception;Techniques;Testing;Ventral Tegmental Area;Water

PROJECT_TITLE: VTA-NAc GABAergic communication underlying stress-induced reward deficits

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

PROJECT_TERMS: Address;Aging;aging and technology;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Artificial Intelligence;Artificial Intelligence enhanced;Businesses;career;Caregivers;Caring;Clinical;Collaborations;Communities;Community Practice;connected care;Dedications;dementia care;design;Development;Directories;Disabled Persons;disadvantaged background;economic disparity;educationally disadvantaged;Emerging Technologies;Enhancement Technology;Ensure;Event;Faculty;Fostering;Gender;Goals;graduate student;Grant;Health;Health Personnel;Health Services;Health system;healthy aging;Home;Human;improved;Individual;industry partner;interest;Journals;K-12 student;Knowledge;Leadership;Massachusetts;Mentors;Methods;monitoring device;multidisciplinary;Needs Assessment;next generation;older adult;online community;outreach;Pilot Projects;Play;Process;Research;Research Personnel;Resources;Role;Science, Technology, Engineering and Mathematics Education;service providers;social;Structure;Students;symposium;synergism;Technology;Training;Translating;Underrepresented Minority;Vision;web site;webinar;Work

PROJECT_TITLE: Massachusetts AI and Technology Center for Connected Care in Aging and Alzheimer's Disease (MAITC): Networking and Mentoring Core


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_DEPT: NUTRITION

PHR: PROJECT NARRATIVE The proposed program will fill a gap in training needed to conduct research to address the problems in maternal and child nutrition that continue to exist in the United States. Training will be provided at the Division of Nutritional Sciences at Cornell University, which has a rich training environment to offer as well as a successful history of providing the kind of integrative and translational training that is proposed.

PI_NAMEs: BELLOWS, LAURA ;FINKELSTEIN, JULIA L. (contact);HODDINOTT, JOHN

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TITLE: TRAINING IN MATERNAL AND CHILD NUTRITION


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Genetics;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_DEPT: ORTHOPEDICS

PHR: PROJECT NARRATIVE  The tendon-bone interface is critical for the transfer of muscle loads to bone in order to move and stabilize the vertebrate skeleton. The structure and size of the tendon-bone interface is sensitive to changes in muscle loads, yet the mechanisms that guide these adaptations remains largely unknown. This proposal will test the role of fibroblast growth factor (FGF) signaling in the cell autonomous and non-cell autonomous responses of the embryonic and postnatal tendon-bone interface in mice following changes in applied muscle loads.

PI_NAMEs: KILLIAN, MEGAN L. (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: ACTA1 gene;Alleles;Behavior;Biomechanics;bone;Bone Growth;Cell Separation;Cells;Chemicals;Chondrocytes;Clinical;comparison control;Deformity;Denervation;Development;Disease;Embryo;Epiphysial cartilage;Extracellular Matrix;FGFR1 gene;FGFR3 gene;Fibroblast Growth Factor;fibroblast growth factor 9;Fibroblast Growth Factor Receptors;Fibrocartilages;gain of function;Genetic;Genotype;Goals;Growth;healing;Hypertrophy;Impairment;in vivo;inducible Cre;innovation;Joints;Knock-out;Knowledge;Ligands;Light;Limb structure;loss of function;LoxP-flanked allele;mechanical load;Mechanics;Mediating;Modification;mouse model;Mus;Muscle;Muscle Contraction;mutant;Mutation;neonatal mice;neonate;nerve supply;novel;optogenetics;Osteoblasts;Pathological fracture;Phenocopy;Phenotype;Physiologic pulse;Population;postnatal;progenitor;Property;receptor;Reporter;response;Role;Secondary to;Signal Pathway;Signal Transduction;skeletal;Skeletal Muscle;Skeleton;Source;Specificity;stem cells;Structure;Techniques;tendon development;Tendon structure;Testing;therapeutic target;Tissues;tomography;tool;United States National Institutes of Health;Visualization;Work

PROJECT_TITLE: FGF signaling during growth and mechanical adaptation of tendon-bone interfaces

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety

PROJECT_TERMS: Acceleration;Acute;Address;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Applications Grants;Area;Artificial Intelligence;Artificial Intelligence enhanced;Assisted Living Facilities;Behavior;Behavior Therapy;Businesses;career;Caregiver Burden;Caregivers;caregiving;Caring;Clinical;clinical care;clinical decision-making;clinically relevant;Cognitive deficits;Collaborations;commercialization;comorbidity;computer science;connected care;Development;Discipline;Disease Progression;Enhancement Technology;Ensure;ethnic diversity;Ethnic Origin;Evaluation;experience;Family;flexibility;follow-up;Fostering;Geriatrics;Goals;Grant;Health;Healthcare Systems;Home;Home environment;human subject;Impaired cognition;improved;individual patient;Industry;Industry Collaboration;innovation;insight;Institution;Institutional Review Boards;Letters;Massachusetts;Medical;Medication Errors;Medicine;Memory;Mentors;Mentorship;Methods;motor deficit;Movement;Neurology;new technology;novel;Occupational activity of managing finances;older adult;Outcome;participant safety;Patients;Persons;Pilot Projects;Play;Process;protective behavior;Psychiatry;Quality of life;Race;racial diversity;Recording of previous events;recruit;Reproducibility;Research;Research Personnel;Resources;response;Risk;Role;Safety;Schools;Shapes;Small Business Innovation Research Grant;Support System;Syndrome;Technical Expertise;Technology;Technology Transfer;Testing;tool;Training Programs;Translating;translational goal;United States;Universities;Work

PROJECT_TITLE: Massachusetts AI and Technology Center for Connected Care in Aging and Alzheimer's Disease (MAITC): Pilot (AD ADRD Focus)


PHR: Tissue-resident memory T cells (T RM) reside throughout the body and provide potent, front-line protective immunity. However, our understanding of the ontogeny, maintenance, and organization of these cells - their ecology - is incomplete. This project will integrate multiple modeling approaches and data from diverse experimental systems, including a unique human tissue resource, to provide a suite of modeling tools for defining the life-histories of T RM in both mice and humans.

PI_NAMEs: FARBER, DONNA L.;YATES, ANDREW  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acute;Adaptive Immune System;Address;Age;age effect;age related;Antigens;Atmosphere;Birth;Carbon;cell age;Cell Maintenance;Cell Survival;Cells;Collaborations;Dedications;defined contribution;Development;Disease;diverse data;DNA;draining lymph node;Ecology;Epithelium;experience;Exposure to;fitness;Generations;Growth;Heterogeneity;Homeostasis;Human;human old age (65+);human tissue;Image;Image Analysis;Imaging Device;Immunity;Immunologist;Immunotherapy;Infection;influenza infection;interdisciplinary approach;Life;life history;Longevity;Lung;Lymphocyte;Maintenance;Maps;Mass Spectrum Analysis;Mathematics;Measures;Memory;Modeling;Monitor;mouse model;Mucous Membrane;Mus;novel;Nuclear;Organ Donor;pathogen;pathogen exposure;Peripheral;Play;Population;Population Dynamics;Population Heterogeneity;Process;Proliferating;quantitative imaging;recruit;residence;response;Role;self-renewal;Site;Spatial Distribution;spatiotemporal;Spleen;Structure;System;T cell response;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Testing;Time;tissue mapping;Tissue Model;tissue resident memory T cell;tissue resource;Tissues;tool;Vaccines;Virus Diseases

PROJECT_TITLE: Modeling the ecology of tissue-resident T cells


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PHR: The Massachusetts AI and Technology Center for Connected Care in Aging and Alzheimer's Disease  (MAITC) seeks to develop and validate health monitoring devices and artificial intelligence  technologies to support healthy aging and Alzheimer's Disease care. The MAITC will play an integral  role in eliciting needs from patients, caregivers, and clinicians and supporting research projects  aimed at developing new and innovative AI-enhanced technologies to address these needs.

PROJECT_TERMS: Acceleration;Address;Aging;aging in place;aging related;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease related dementia;Applications Grants;Area;Artificial Intelligence;Artificial Intelligence enhanced;Businesses;care delivery;career;Caregivers;Caring;Chronic Disease;Clinical;Collaborations;commercialization;Communities;computer science;connected care;Development;disability;Discipline;Elderly;Enhancement Technology;Ensure;ethnic diversity;Ethnic Origin;Evaluation;evidence base;experience;feasibility testing;flexibility;follow-up;Fostering;functional decline;Geriatrics;Gerontology;Goals;Grant;Health;Health Promotion;healthy aging;high risk;Home;human subject;improved;Industry;Industry Collaboration;informal caregiver;innovation;Institution;Institutional Review Boards;Knowledge;late life;Lead;Letters;Loneliness;Massachusetts;Mental Depression;Mental Health;Mentors;Mentorship;Methods;middle age;Monitor;monitoring device;Movement;new technology;novel;Occupational activity of managing finances;older adult;Outcome;participant safety;Patients;Personal Satisfaction;Physical activity;Pilot Projects;Play;poor health outcome;Population;Populations at Risk;Procedures;Process;Quality of life;Race;racial diversity;Reduce health disparities;Reproducibility;Research;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Role;rural area;Schools;Science;Sleep;Small Business Innovation Research Grant;social;Social isolation;success;Technical Expertise;Technology;Technology Transfer;telehealth;Testing;tool;Training Programs;Translating;translational goal;United States;Universities;Vulnerable Populations;Work

PROJECT_TITLE: Massachusetts AI and Technology Center for Connected Care in Aging and Alzheimer's Disease (MAITC): Pilot Core (Aging Focus)


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: NARRATIVE This project will improve our understanding of the brain mechanisms underlying the planning of speech and how this process is disrupted in persons who stutter. The outcome of this research is expected to significantly accelerate the development of treatments for stuttering, which would have a profound impact on millions of people affected by this disorder.

PI_NAMEs: GUENTHER, FRANK H (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acceleration;Achievement;Address;Adult;Adverse effects;Affect;Anterior;Apraxia;Area;Behavioral;Brain;Brain region;Buffers;Cell Nucleus;Cerebellum;Child;Clutterings;comparison control;Complex;design;Development;Developmental Stuttering;Disease;Dissociation;Dysarthria;effective therapy;experimental study;Functional Magnetic Resonance Imaging;Funding;Gestures;Goals;Impairment;improved;Individual;inferior frontal sulcus;Learning;Left;Memory impairment;Modeling;Motor;Motor Cortex;Movement;Nature;neural;Neurobiology;neuroimaging;neuromechanism;Neurophysiology - biologic function;neuroregulation;new technology;novel;novel therapeutics;Occupational;Outcome;Outcomes Research;Participant;Performance;Personal Satisfaction;Persons;phonology;Prevalence;Process;Production;programs;psychologic;Quality of life;repository;Role;Severities;Short-Term Memory;Site;social;Speech;Speech Disorders;Speech Sound;Speed;Stimulus;Study models;Stuttering;Taxes;Technology;Testing;therapy development;United States;word learning

PROJECT_TITLE: Sequencing and Initiation in Speech Production

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Clinical Research;Lung;Pulmonary Fibrosis;Rare Diseases

PHR: PROJECT NARRATIVE Idiopathic pulmonary fibrosis is a progressive scarring disease of the lungs with minimally effective therapies. This project is relevant to the overall NIH mission of public health because it identifies a specific potassium ion channel – the BK channel – as a novel enabler of myofibroblast activation and ultimately, pulmonary fibrosis. Targeting BK channels would be a new strategy for the treatment of this deadly disease.

PI_NAMEs: HUANG, STEVEN K (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Actins;Animal Model;Biology;Bladder;Blood Vessels;Calcium Channel;Calcium Signaling;cell type;Cicatrix;clinical heterogeneity;Code;Contracts;Cytoplasm;Data;Development;Disease;disease model;Disease Progression;DNA Methylation;Drug Targeting;effective therapy;Epigenetic Process;Exhibits;Extracellular Matrix;Fibroblasts;fibrogenesis;Fibrosis;Future;Gene Expression Profile;Genes;Genome;Goals;Grant;idiopathic pulmonary fibrosis;in vivo;interest;Ion Channel;Laboratories;large-conductance calcium-activated potassium channels;Literature;Lung;Lung Diseases;lung injury;Mediator;Methylation;Mission;Mus;Myofibroblast;novel;novel therapeutic intervention;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Play;Potassium;Potassium Channel;Public Health;Publications;Publishing;Pulmonary Fibrosis;Pulmonary Inflammation;Relaxation;response;Role;Signal Transduction;Smooth Muscle;Stimulus;success;targeted treatment;Testing;Therapeutic;Time;United States National Institutes of Health;Up-Regulation;Work;wound

PROJECT_TITLE: The Role of KCNMB1 and the Large Conductance Potassium (BK) Channel in Myofibroblast Differentiation and Pulmonary Fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Biomedical Imaging;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dental, Oral, and Craniofacial Disease;Disability Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention

ORG_DEPT: OTOLARYNGOLOGY

PHR: Public Health Relevance Statement Smell dysfunction and its neurologic consequences following viral infection remain poorly understood despite a growing prevalence following the current SARS-CoV-2 pandemic. Studying epidemiologic risk factors and the associations between smell loss and deficits in central neurologic processing present an opportunity to better characterize post-viral smell dysfunction, identify at-risk populations for preventative interventions, and inform future investigation into central brain circuitry processing of scents.

PI_NAMEs: OVERDEVEST, JONATHAN B (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: 2019-nCoV;Address;Affect;Alzheimer's Disease;Anatomy;Anosmia;Autoimmune Diseases;Awareness;Biological Markers;Brain;brain circuitry;career;Caring;Chemicals;Clinical;Clinical Trials;cohort;Cohort Studies;comorbidity;Competence;Counseling;COVID-19;COVID-19 associated anosmia;COVID-19 impact;COVID-19 pandemic;COVID-19 risk;COVID-19 susceptibility;Cross-Sectional Studies;daily functioning;Data;Data Analyses;Data Correlations;Database Management Systems;Demographic Factors;design;Development;Diabetes Mellitus;disability;disabled;Discrimination;Dizziness;Doctor of Philosophy;Encephalitis;entorhinal cortex;Epidemiology;epidemiology study;Ethnic Population;Evaluation;experience;Fatigue;Foundations;Frequencies;Functional disorder;functional outcomes;Future;Goals;Head and Neck Surgery;Headache;High Prevalence;Hospitals;human old age (65+);imaging modality;Immune response;Impairment;improved;Individual;Infection;infection rate;Inflammatory;Intervention;Investigation;K-Series Research Career Programs;Knowledge;Learning;Longitudinal cohort study;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Medical;Medical center;Memory;Mentors;Mentorship;Minority Groups;Mission;Modality;Monitor;Movement Disorder Society Unified Parkinson's Disease Rating Scale;multi-ethnic;Multilingualism;Nasopharynx;National Institute on Deafness and Other Communication Disorders;Nervous System Physiology;neural circuit;Neurocognition;Neurocognitive;Neurodegenerative Disorders;Neuroepidemiology;neuroimaging;Neurologic;Neurologic Dysfunctions;Neurological disability;Neurological outcome;neuropsychiatry;Neuropsychology;neurosensory;New York;novel coronavirus;Obesity;olfactory bulb;Olfactory dysfunction;Olfactory Pathways;Otolaryngology;Outcome;Pathology;patient oriented research;Patients;Perception;Physicians;Pilot Projects;Population;Populations at Risk;Positron-Emission Tomography;post SARS-CoV-2 infection;Predictive Factor;predictive modeling;Presbyterian Church;Prevalence;preventive intervention;professor;programs;public health relevance;Quality of life;Recovery;recruit;Research;Research Design;Research Infrastructure;Research Methodology;Risk;Risk Factors;SARS-CoV-2 infection;Seizures;Sensory;Sensory disabilities;Sensory Disorders;Severe Acute Respiratory Syndrome;Severities;Smell Perception;Strategic Planning;Stroke;Structure;Symptoms;Taste Perception;Testing;Thick;tool;Training;United States;United States National Institutes of Health;Universities;Viral;Virus;Virus Diseases;Vulnerable Populations;Work

PROJECT_TITLE: Neurocognitive & neuropsychiatric impact of chemosensory alterations: Implications of olfactory dysfunction in COVID-19

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative The ability to develop new drugs to treat diseases depends on our ability to manipulate biological complexity with precision and control. The Harvard Ph.D. program in Chemical Biology is an interdisciplinary program that trains students to use chemistry to investigate and manipulate biological processes, and to develop new technologies to accelerate research relevant to biology and medicine. This proposal requests support to continue this successful program.

PI_NAMEs: BALSKUS, EMILY PATRICIA;COLE, PHILIP A (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Harvard Chemical Biology PhD Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on providing mechanistic insight to develop a new and more effective treatment strategy to overcome resistance to immunotherapy in glioblastoma (GBM), a disease with dismal overall prognosis. The proposal aims to determine key epigenetic factor(s) regulating myeloid cell-mediated immune suppression and to target these epigenetic factor(s) to overcome resistance to immunotherapy in GBM. Thus, the proposed research is relevant to the part of the National Institutes of Health’s (NIH’s) mission that pertains to identification of novel strategies to overcome resistance to immunotherapy.

PI_NAMEs: GOSWAMI, SANGEETA  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Affect;anti-PD1 therapy;Antigen Presentation;Antigen Presentation Pathway;Automobile Driving;Biological Assay;Biological Models;Brain Neoplasms;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cell Physiology;Cells;Cellular biology;checkpoint therapy;ChIP-seq;Chromatin;Clinical;combinatorial;Combined Modality Therapy;Data;Dendritic Cells;Detection;Disease;effective therapy;effector T cell;efficacy evaluation;Enzymes;Epigenetic Process;epigenetic regulation;Gene Expression;Gene Expression Regulation;Glioblastoma;Goals;histone demethylase;Histone H3;Histones;Human;Image;Immune;immune resistance;Immune response;Immunosuppression;Immunotherapy;improved;In Vitro;indexing;Infiltration;Inflammatory;inflammatory milieu;innovation;insight;Interferons;Knowledge;Link;Lysine;Macrophage;Mediating;Microglia;Mission;Modeling;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;novel strategies;Outcome;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;personalized immunotherapy;Phagocytes;Phagocytosis;Phagocytosis Inhibition;pharmacologic;Phenotype;Play;pre-clinical;Pre-Clinical Model;Prognosis;programs;Public Health;Research;Resistance;Resolution;response;RNA;Role;Sampling;selective expression;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;small molecule inhibitor;standard of care;System;T cell infiltration;T cell regulation;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapy resistant;treatment strategy;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;United States National Institutes of Health;Work

PROJECT_TITLE: Targeting epigenetic machinery to overcome myeloid cell-mediated resistance to anti-PD-1 therapy in GBM

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIR-W(01)Q]


ORG_DEPT: OTHER BASIC SCIENCES

PHR: Project Narrative One key decision that humans and animals must repeatedly make when pursuing a goal is deciding when to stop, a decision process that can become dysfunctional in disorders ranging from attention deficit hyperactivity disorder to obsessive compulsive disorder to addiction. Here, we propose a study of the role of lateral habenula neural circuits in promoting disengagement from goal pursuit. Our findings will suggest new targets for potential therapeutic intervention in disorders associated with excess or insufficient commitment to goals.

PI_NAMEs: WARDEN, MELISSA RHOADS (contact)

PROJECT_TERMS: addiction;Affect;Animals;Attention deficit hyperactivity disorder;Basal Ganglia;Behavior;Behavioral;Bipolar Disorder;Brain Stem;Cell Nucleus;Consumption;Data;Disease;Dopamine;dorsal raphe nucleus;driving force;endopeduncular nucleus;Environment;Equilibrium;Event;Failure;Fiber;Fire - disasters;Functional disorder;Globus Pallidus;Glutamates;Goals;Habenula;Human;Hypothalamic structure;insight;Investigation;Lateral;Medial;Mental Depression;Methods;microendoscopy;Midbrain structure;Monitor;Mus;Negative Valence;neural;neural circuit;Neurons;neurophysiology;neuroregulation;Obsessive-Compulsive Disorder;Optical Methods;Optics;optogenetics;Photometry;Physiological;Positive Valence;Preoptic Areas;Process;Prosencephalon;Punishment;Reaction;Regulation;Resolution;response;Rewards;Role;Science;Serotonin;Testing;Therapeutic Intervention;Time;Water;Work

PROJECT_TITLE: Lateral habenula circuits for the regulation of goal-directed behavior


ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Narrative In autoimmune encephalitis and paraneoplastic disorders, T cells play an important role in pathogenesis, but our understanding of this process is limited because identifying the antigen targets of T cells is difficult with current technologies. This project aims to accelerate T cell antigen discovery for these and other autoimmune neurologic disorders like multiple sclerosis with a new technology that allows the profiling of T cell responses at the single cell level in a multiplexed fashion.

PI_NAMEs: GERDTS, JOSIAH  (contact)

PROJECT_TERMS: Acceleration;Address;Affinity;Antibodies;antigen detection;Antigen Presentation Pathway;Antigen Targeting;Antigen-Presenting Cells;Antigens;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmune Diseases of the Nervous System;Autoimmune encephalitis;Autoimmunity;Award;B-Lymphocytes;Binding;Biological Assay;Biology;Biosensor;Blood specimen;California;career development;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Communication;Cells;cellular engineering;Central Nervous System;Cerebrospinal Fluid;Clinical;Clinical Immunology;Clone Cells;CNS autoimmune disease;Complex;cytokine;Cytomegalovirus;Data Collection;Dedications;design;Detection;Development;Diagnosis;diagnostic biomarker;Disease;Doctor of Philosophy;Educational process of instructing;Encephalitis;Engineering;Environment;experience;experimental study;Faculty;Future;future implementation;Goals;Human;human disease;ICAM1 gene;Immunity;immunological synapse;immunological synapse formation;Immunology;Immunosuppressive Agents;improved;Individual;Infiltration;Infrastructure;innovation;Integrins;intercellular communication;Knowledge;Laboratories;Lead;Libraries;Ligands;Measurement;Measures;Mechanics;member;memory CD4 T lymphocyte;Meningitis;Mentors;Mentorship;Methods;MHC Class I Genes;Molecular Conformation;Multiple Sclerosis;multiplex assay;Nervous System Paraneoplastic Syndromes;neuroimmunology;Neurologist;Neurology;new technology;next generation;novel;oligodendrocyte-myelin glycoprotein;Pathogenesis;pathogenic autoantibodies;Patients;Peptides;Peripheral;peripheral blood;Pharmaceutical Preparations;Physicians;Physiological;Play;Postdoctoral Fellow;Precision therapeutics;Process;Production;Productivity;professor;programs;Proliferating;Proteins;Proteome;Research;response;Role;Safety;San Francisco;Scientist;screening;Sensitivity and Specificity;sensor;sensor technology;seropositive;Specificity;synthetic biology;T cell response;T-Cell Activation;T-cell receptor repertoire;T-Lymphocyte;Technology;Testing;Therapeutic;Tissues;tool;Training;translational research program;Universities;Viral;Viral Antigens;Work

PROJECT_TITLE: A synthetic biosensor of immunologic synapse formation allowing multiplexed T cell antigen discovery for autoimmune neurologic disorders

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative - Overall The latent reservoir for HIV-1 in resting CD4+ T cells is a major barrier to curing the infection. This research program will investigate how the reservoir is established and maintained using coordinated studies in people living with HIV-1 and in SIV-infected macaques.

PI_NAMEs: SILICIANO, ROBERT F (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Affect;Antibodies;Antigen Presentation;antiretroviral therapy;Apoptosis;Biological Assay;Biology;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Survival;Cells;Characteristics;Circulation;Data;design;Development;DNA;Event;Gene Expression;Generations;Goals;HIV-1;Infection;insight;integration site;Kinetics;latent HIV reservoir;Lymphoid Tissue;Macaca;Mediating;Modeling;Mutation;Natural Killer Cells;Nature;Pathogenesis;Persons;Phase;Phenotype;Plasma;Process;Production;Productivity;programs;Property;Proviruses;Research;Research Personnel;Resistance;Rest;Sampling;Seminal;single cell analysis;single cell technology;SIV;Testing;trafficking;Transcription Coactivator;Transcription Repressor;Viral;Viral Genes;Viral Genome;Virus

PROJECT_TITLE: Understanding reservoir dynamics through analysis of viral decay processes


PROJECT_TERMS: central database;Collaborations;Ensure;Geography;HIV;HIV Infections;innovation;Joints;Manuscripts;mathematical model;Measurement;meetings;Modeling;Monitor;nonhuman primate;Persons;Preparation;Prevention;Process;programs;Research;Research Personnel;shared database;United States National Institutes of Health;Update;Viral;virtual laboratory;Virus Diseases;Work

PROJECT_TITLE: Administrative Core


PI_NAMEs: PERELSON, ALAN S (contact)

PROJECT_TERMS: Address;Adverse drug effect;Affect;Aftercare;antiretroviral therapy;Bioinformatics;Biological Assay;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Collaborations;computing resources;Data;Data Analyses;data integration;Data Set;Development;DNA;Drops;dynamic system;Event;experimental analysis;Experimental Designs;Fostering;Generations;Goals;HIV;HIV Infections;HIV-1;Immune response;Immune system;Individual;Infection;Infection Control;innovation;insight;Kinetics;Laboratories;latent HIV reservoir;Length;mathematical model;Measures;member;Mission;Modeling;Mutation;Natural Killer Cells;nonhuman primate;novel;Persons;Phase;Plasma;Population;predictive modeling;Process;programs;Property;Proviruses;Public Health;Research;Research Project Grants;Research Support;response;Rest;Sampling;Shapes;simulation;SIV;synergism;System;T-Cell Depletion;Techniques;Testing;Time;Tissues;Viral;viral rebound;Viremia;Virus

PROJECT_TITLE: Mathematical Modeling Core


PROJECT_TERMS: Acceleration;Affect;Antigen Presentation;antiretroviral therapy;Apoptosis;Biological Assay;Blood;CD4 Positive T Lymphocytes;Cell Survival;Cells;Characteristics;Data;design;Development;digital;DNA;effective therapy;Evaluation;falls;Frequencies;Gene Expression;Generations;genome sequencing;Half-Life;HIV;HIV-1;Infection;insight;integration site;Kinetics;Laboratories;Macaca;Measurement;Measures;Modeling;Mutation;novel;novel strategies;Participant;Pathogenesis;Persons;Phase;Plasma;Population;Process;Production;Productivity;Property;Proviruses;Research Personnel;Research Project Grants;Resistance;RNA;RNA I;Sampling;SIV;Sorting;Testing;trafficking;Transcription Coactivator;Transcription Repressor;transcriptomics;treatment duration;Viral;Viral Genes;Viremia;Virus

PROJECT_TITLE: Project 1: Analysis of 2nd phase decay in persons living with HIV


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PI_NAMEs: BAROUCH, DAN H. (contact)

PROJECT_TERMS: Address;Aftercare;antibody-dependent cell cytotoxicity;Apoptosis;Biological Assay;Blood;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Survival;cell type;Cells;Circulation;design;DNA;Epitopes;experimental study;Frequencies;Gene Expression;HIV-1;Human;Immunologic Stimulation;Individual;Infection;insight;lymph nodes;Lymphoid Tissue;Macaca;Macaca mulatta;Measurement;Mediating;Modeling;Mutation;Nature;neutralizing antibody;nonhuman primate;novel;Pathogenesis;Peripheral;Phase;Plasma;Population;Population Analysis;Prevention;Process;Property;Research Personnel;Resistance;Rest;Shapes;simian human immunodeficiency virus;single cell genomics;SIV;Spleen;Testing;Time;Vaccine Therapy;Viral;Viral Genes;viral rebound;Viral reservoir;Viremia;Virus

PROJECT_TITLE: Project 2: Analysis of Reservoir Dynamics in SIV-Infected Rhesus Macaques


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome;Nutrition

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Humans carry enormous communities of non-harmful gut bacteria (the microbiome) which have a two-sided relationship with the foods we eat: on one hand, dietary components can disrupt these bacterial communities; at the same time, gut bacteria can change these dietary components. These activities intersect when we encounter food-borne infections, which impact tens of millions of people every year in the USA and are strongly influenced by both diet and the microbiome. This proposal presents a plan to understand how an individual's microbiome transforms (and is transformed by) dietary components in our food, and how these interactions determine the outcome of food-borne infections.

PI_NAMEs: GALAN, JORGE E;GOODMAN, ANDREW L (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: absorption;Address;Animal Model;Animals;Antibiotics;Area;Bacteria;bacterial community;Bacterial Infections;Biological Markers;biomarker identification;Campylobacter jejuni;Cardiovascular Diseases;Chicken Model;Chickens;Circulation;Clinical Research;cohort;Collection;colonization resistance;commensal microbes;Communities;Consumption;Custom;Diet;Diet Modification;dietary;Dietary Component;Disease;Drug Kinetics;drug metabolism;Eating;enteric pathogen;Enzymes;Exclusion;Food;Food Chain;foodborne;foodborne illness;foodborne infection;gastrointestinal;Gastrointestinal tract structure;Gnotobiotic;Growth;gut bacteria;gut microbes;gut microbiome;gut microbiota;Human;Human Microbiome;human microbiota;human model;In Vitro;Individual;Infection;Infection prevention;Inflammatory;Intervention;Intestines;Knowledge;Libraries;liquid chromatography mass spectrometry;Malignant Neoplasms;Maps;Mathematics;Measurement;Measures;Mediating;Medical;medical examination;Metabolism;metabolomics;Microbe;microbial;microbiome;microbiome composition;microbiota;Modeling;monolayer;Mus;Organoids;Outcome;pathogen;Persons;Pharmaceutical Preparations;Physiology;Pilot Projects;Play;Population;Poultry Products;predictive marker;Property;Public Health;Reporting;repository;resident commensals;Risk;Salmonella enterica;Salmonella typhimurium;Series;Shapes;Side;small molecule;Surveys;Techniques;Testing;Time;Variant;Virulence;Virulence Factors;Xenobiotic Metabolism;Xenobiotics

PROJECT_TITLE: Diet transformation by the microbiome and its impact on bacterial infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-N(80)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The proposal’s overall goal is to investigate the mechanism of a fundamental process necessary for biosynthesis of messenger RNAs, key intermediates in the flow of information from genes to proteins. This recently discovered process, termed telescripting, is crucial for protecting nascent gene transcripts and enhances cells’ ability to produce a great diversity of proteins they need for their functions and to changes in their environment. Telescripting changes can profoundly affect expression of genes associated with many diseases and knowledge of its mechanism will advance prospects of new therapies.

PI_NAMEs: DREYFUSS, GIDEON  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 3' Untranslated Regions;Acute;Affect;Anabolism;Antisense Oligonucleotides;Base Pairing;Binding;Biology;Cell Proliferation;Cells;Code;Complex;Disease;druggable target;Environment;environmental change;Equilibrium;Event;Excision;Foundations;Future;Gene Expression;Gene Expression Process;Genes;Genetic Transcription;Goals;Human;Intervention;Introns;Knowledge;Length;Life;Location;Malignant Neoplasms;Maps;Medicine;Messenger RNA;Molecular;mRNA Cleavage and Polyadenylation Factors;novel therapeutics;Nuclear RNA;Organism;Output;overexpression;particle;Polyadenylation;premature;prevent;Process;Production;Protein Isoforms;Proteins;Regulation;RNA Polymerase II;RNA Splicing;Role;Signal Transduction;Site;Specific qualifier value;stoichiometry;Transcript;transcription termination;transcriptome;U1 Small Nuclear Ribonucleoprotein;U1 small nuclear RNA;Untranslated RNA;Up-Regulation

PROJECT_TITLE: Mechanism and Regulation of U1 snRNP Telescripting

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer

PHR: PROJECT NARRATIVE For a subset of patients with lung cancer, immunotherapy has led to long-lasting remissions. However, because the majority of patients fail to respond, increasing the efficacy of immunotherapy for non-responders remains a critical priority of cancer research. This project seeks to identify and characterize anti-tumor T cells in lung cancer patients, to inform the development of novel therapies that enhance the anti-tumor response for treatment non- responders.

PI_NAMEs: LEE, MARK N. (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Acceleration;Achyrocline;Adoptive Cell Transfers;Advisory Committees;American;anti-cancer research;Antigen-Presenting Cells;Antigens;Antitumor Response;Atlases;Blood;Blood specimen;blood-based biomarker;Board Certification;Cancer Biology;Cancer Etiology;cancer genome;cancer genomics;Cancer Patient;career;career development;Cells;Cessation of life;Circulation;Clinical;Clone Cells;Communication;Complex;cost;cytokine;Dana-Farber Cancer Institute;Development;Development Plans;Disease remission;DNA;Doctor of Medicine;Doctor of Philosophy;Environment;exhaustion;experience;Foundations;Frequencies;Goals;Grant;Hospitals;Human;immune checkpoint blockade;Immune response;Immunology;Immunooncology;Immunotherapy;Individual;instructor;interest;International;Laboratories;Leadership;Lung;Malignant neoplasm of lung;Mediating;Medical;medical schools;Mentors;Methodology;Methods;migration;neoplastic cell;new technology;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Oligonucleotide Microarrays;Oncology;Pathologic;Patient Selection;patient subsets;Patients;Peptide Receptor;Peptides;peripheral blood;Physicians;Positioning Attribute;Professional Competence;programmed cell death protein 1;programs;Proteins;Recording of previous events;Research;Resource Development;response;Scientist;single cell sequencing;Solid Neoplasm;Specimen;stem;System;T cell therapy;T-Cell Activation;T-Cell Receptor;T-Cell Receptor Therapy;T-Lymphocyte;Technology;Testing;Therapeutic;Training;Training Programs;transfusion medicine;treatment response;tumor;Tumor Antigens;tumor immunology;tumor specificity;United States;Woman;Writing

PROJECT_TITLE: The antigen specificity of tumor-targeting T cells in non-small cell lung cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Fentanyl Misuse and Addiction;Lung;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_NAME: LOVELACE BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: NM

PHR: PROJECT NARRATIVE Inhalation of aerosolized carfentanil has been used as a lethal agent (bioweapon) to cause respiratory disorder and death in humans. This proposal will determine the characteristics, elucidate the mechanisms, and provide a potential countermeasure of the respiratory disorder (death) in a rat model.

PI_NAMEs: XU, FADI  (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Abbreviations;Acute;aerosolized;afferent nerve;Afferent Neurons;Agonist;Anesthesia procedures;Animals;antagonist;Apnea;awake;Binding;bioweapon;Blood;Brain Stem;C Fiber;Carbon Dioxide;carfentanil;Carotid Body;Cell Nucleus;Cells;Central Sleep Apnea;Cerebrospinal Fluid;Cessation of life;Characteristics;Chemoreceptors;Chest;Chest wall structure;Clinical;constriction;Coupled;Data;Dependence;Deposition;Depressed mood;dermorphin;desensitization;Dose;Doxapram;efficacy evaluation;Electrophysiology (science);Exposure to;External Intercostal Muscle;Fentanyl;fentanyl overdose;Frequencies;Ganglia;Gender;Human;Hypoxia;hypoxic depression;Immunohistochemistry;improved;In Vitro;in vivo;Inhalation;Injections;interdisciplinary approach;Intravenous;Intravenous Bolus;intravenous injection;Larynx;Lung;Mediating;Modeling;mu opioid receptors;mu receptors;Muscle;Naloxone;Neurons;novel;Opioid;opioid abuse;opioid overdose;Overdose;overdose death;Perfusion;Peripheral;Pharmacology;Pilot Projects;Play;preBotzinger complex;prevent;Rattus;receptor;Receptor Inhibition;receptor internalization;Reporting;Reproducibility;Respiration Disorders;respiratory;Respiratory Muscles;Respiratory Stimulants;response;Resuscitation;Role;Stimulant;Survival Rate;synthetic opioid;Therapeutic Uses;Thyroarytenoid Muscle;Tidal Volume;Time;ventilation;Ventilatory Depression

PROJECT_TITLE: Mechanism and Countermeasure of Carfentanil-induced Respiratory Disorder and Death


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Enteroviruses and rhinoviruses evolve within picornavirus species groups. Viral RNA recombination, a form of sexual replication, contributes to the formation of species groups and to the ongoing evolution of viruses within species groups. Our study will advance our understanding of picornavirus species groups, reveal molecular features of viral polymerases that maintain species groups in nature, further elucidate the antiviral mechanisms of ribavirin, and provide opportunities to control or eradicate important pathogens such as polioviruses, rhinoviruses and EV-D68.

PI_NAMEs: BARTON, DAVID J (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Active Sites;Affect;asexual;Biochemical;Biological;Data;Disadvantaged;Enterovirus;Enterovirus 68;Enterovirus 71;Evolution;experimental study;Family Picornaviridae;fitness;Funding;Genetic Materials;Genetic Recombination;Genome;grasp;Human poliovirus;Impairment;In Vitro;in vivo;Mediating;Molecular;Mutation;Nature;Outcome;pathogen;Poliomyelitis;Polymerase;Population;Predisposition;purge;Rhinovirus;Ribavirin;RNA;RNA replication;RNA Viruses;Shapes;theories;Viral;viral RNA;Virus;Work

PROJECT_TITLE: Enterovirus RNA Replication and Recombination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Y(02)]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

PHR: Candida albicans is the most common cause of human fungal disease, yet how it causes lethal invasive disease is not well-understood. We recently discovered a novel mechanism of immune modulation in which a Candida albicans secreted lipase, Lip2, drives virulence by suppressing an IL-17 antifungal immune response in deep tissues. In this work, we will build on these new insights to identify the host proteins that mediate this response, thereby producing a new molecular understanding of an invasive fungal pathogen causes disease and enabling the identification of new therapeutic targets.

PI_NAMEs: KAMBER, ROARKE ALEXANDER;MADHANI, HITEN D;NOBLE, SUZANNE M (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Animals;anti-fungal agents;Antibodies;ANXA2 gene;Biological;Blood Circulation;Bone Marrow;Candida albicans;cell preparation;Cell surface;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;CRISPR screen;cytokine;Data;Dendritic cell activation;Dendritic Cells;Disease;Disseminated candidiasis;Dyes;Exhibits;experimental study;Exposure to;Fatty Acids;Foundations;Fungal Components;Genes;genetic approach;genome-wide;Genomic DNA;gut microbiota;high risk;Host Defense;Hour;Human;Hydrolysis;IL17 gene;Immune;immune activation;Immune response;Immunity;immunoregulation;Immunosuppression;In Vitro;Incubated;Infection;innate immune mechanisms;insight;Integration Host Factors;Interleukin-1 beta;interleukin-23;Interleukin-6;Invaded;Kidney;Knock-out;Knockout Mice;Libraries;Lipase;Lipids;Macrophage;Mediating;Messenger RNA;Microbe;Modeling;Molecular;Morphogenesis;mouse model;Mucocutaneous Candidiasis;Mus;mutant;Mycoses;Natural Immunity;new therapeutic target;Nonesterified Fatty Acids;novel;Organ;Palmitic Acids;pathogen;Pathogenesis;pathogenic bacteria;pathogenic fungus;pathogenic virus;prevent;Production;Proteins;response;Role;Sepsis;Signal Pathway;Signal Transduction;Solid;Sorting;Source;Stains;Systemic infection;T-Lymphocyte;Testing;Tissues;TLR2 gene;TLR4 gene;Virulence;Work;Yeasts

PROJECT_TITLE: Deciphering a novel lipid-based mechanism of innate immune modulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-M(90)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Palliative Care;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Older sexual gender and minority patients with serious illness are understudied and underserved. Here we propose a career development program to recruit younger investigators to focus on these patients and help improve their lives.

PI_NAMEs: JATOI, AMINAH  (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Address;Advisory Committees;Advocate;Age Years;Aging;Anxiety;Applications Grants;asexual;Award;cancer therapy;career;career development;Caring;Cessation of life;Child;Clinic;Clinical;clinical center;Clinical Sciences;Comprehensive Cancer Center;course development;Data;data centers;Development;Diagnosis;Discrimination;Disease;Disparity;Do Not Resuscitate Order;Educational Curriculum;Elderly;end of life;Environment;experience;Face;Family;family structure;Funding;gender minority group;General Population;Goals;Grant;Health Personnel;Healthcare;Home;human old age (65+);improved;Individual;Infrastructure;Inpatients;Institution;interest;International;intersectionality;Intersex;Interview;Leadership;Learning;lectures;Lesbian Gay Bisexual;Lesbian Gay Bisexual Transgender;Loneliness;Malignant Neoplasms;Mayo Clinic Cancer Center;Medical Electronics;Medical Staff;Medicare;Mental Depression;Mental Health;Mentors;Methodology;Minnesota;minority patient;multidisciplinary;Needs Assessment;novel;older patient;Oncologist;Outcome;palliation;Palliative Care;Participant;Pastoral Care;Patient Self-Report;Patients;Persons;Physicians;Pilot Projects;Positioning Attribute;preference;Principal Investigator;professor;Program Development;programs;psychosocial;Psychosocial Influences;Publications;queer;recruit;Religion;Religiosity;Request for Applications;Research;Research Personnel;Research Proposals;Resources;Review Literature;Risk;Same-sex;Series;Sexual and Gender Minorities;sexual minority group;sexual minority men;sexual minority women;social;social media;Social support;statistics;Surveys;symposium;symptomatology;Symptoms;transgender;Translational Research;two spirit;Underserved Population;United States National Institutes of Health;Visit

PROJECT_TITLE: Older Sexual and Gender Minority Patients with Serious Illness:  Program-Building to Identify and Address Needs

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative The experiments outlined here will establish a novel link between the activity of autophagy and the efficiency of photopic dark adaptation. These studies will identify new mechanisms that modulate the function and survival of cone photoreceptors in normal and diseased conditions, paving the way for future translational studies.

PI_NAMEs: FERGUSON, THOMAS ALMON;KEFALOV, VLADIMIR JIVKOV (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Ablation;Acceleration;Acute;Affect;Autophagocytosis;Blindness;Bypass;Cells;Cellular Stress;chromophore;Cone;Dark Adaptation;Darkness;Data;Degradation Pathway;Disease;Electrophysiology (science);Electroretinography;Eukaryotic Cell;Exercise;experimental study;Exposure to;Fasting;Future;Genetic;Health;Homeostasis;Human;in vivo;Intermittent fasting;Kinetics;Light;light effects;Link;Measures;Mediating;Metabolic;Metabolism;Muller's cell;Mus;Natural regeneration;novel;Pathway interactions;Photoreceptors;Physical Exercise;Physiological;Play;Predisposition;prevent;Process;Recovery;Recycling;Reporter;response;Retinal Cone;Retinal Degeneration;Retinal Pigments;Rod;Role;Signal Transduction;Starvation;Stress;Structure of retinal pigment epithelium;Synaptic Transmission;Testing;translational study;Up-Regulation;Vertebrate Photoreceptors;Vision;Visual;visual cycle;Work

PROJECT_TITLE: Modulation of cone photoreceptor function by autophagy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-M(02)M]