NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Burden of Illness;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Disability Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: PROJECT NARRATIVE / PUBLIC HEALTH STATEMENT This project aims to bridge the gap between assistive devices and rehabilitative tools so that stroke patients with a paretic arm can immediately return to their daily routine and use their activities of daily living as a patient-specific rehabilitation strategy. Assistive bionic exoskeletons will be intuitively controlled with residual muscle activity from the paretic arm, and artificial intelligence will elucidate underlying muscle impairment, improve the dexterity of bionic devices, and temporarily assist and rehabilitate stroke patients. This proposal is relevant to NIH’s mission because it has strong potential to improve quality of life for stroke patients and their caregivers, as well as reduce overall healthcare costs.

PI_NAMEs: GEORGE, JACOB ANTHONY (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Acceleration;Activities of Daily Living;Acute;Affect;Agreement;Algorithms;arm paresis;Artificial Intelligence;Award;Bionics;career;career development;Caregiver Burden;Caregivers;Chronic;Clinical;Collaborations;Data Set;data visualization;Dedications;deep learning;Development;Development Plans;Devices;dexterity;disability;Doctor of Philosophy;Educational workshop;Electromyography;Event;exoskeleton;Faculty;faculty mentor;functional restoration;Funding;Goals;graduate student;Grant;Growth;Hand;handbook;Health Care Costs;hemiparetic stroke;High Performance Computing;holistic approach;Hospitals;HRK gene;Human Subject Research;Impairment;improved;Individual;innovation;Institution;Intuition;Knowledge;Leadership;lecturer;Machine Learning;Manuscripts;Mentors;Mentorship;Mission;Motor;Muscle;Muscle Spasticity;muscle strength;Nerve Regeneration;neurological rehabilitation;Neuromuscular Diseases;Orthotic Devices;Paresis;patient oriented;Patients;Physical Medicine;Physical Rehabilitation;Pilot Projects;post stroke;Postdoctoral Fellow;professor;Public Health;Publishing;Quality of life;Recovery;Rehabilitation Centers;rehabilitation strategy;Rehabilitation therapy;Research;Research Personnel;Research Technics;Residual state;Running;Secure;Self-Help Devices;Services;skills;social;Societies;Spinal cord injury;strength training;Stroke;stroke outcome;stroke patient;stroke recovery;Students;symposium;System;tenure track;Time;tool;Training;Translational Research;Traumatic Brain Injury;undergraduate student;United States National Institutes of Health;Universities;Upper Extremity;upper limb hemiparesis;Utah;Vision;visual feedback

PROJECT_TITLE: Patient-centered rehabilitation and dexterous assistive devices for stroke patients using bionic exoskeletons controlled by non-invasive electromyography

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)R]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Gene Therapy;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

ORG_CITY: CORAL GABLES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SURGERY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Patients with no-option critical limb ischemia (CLI) face to major limb amputations and huge health care costs. We propose to develop novel gene therapy, which employs E-selectin to prime ischemic limb to increase neovascularization and regeneration in ischemic tissues while decreasing tissue damage. It will ultimately eliminate the need for amputation and transform the care for PAD/CLI patients.

PI_NAMEs: LIU, ZHAO-JUN ;VELAZQUEZ, OMAIDA C (contact)

PROGRAM_OFFICER_NAME: LUO, JAMES

PROJECT_TERMS: Acceleration;adenoviral mediated;Amputation;angiogenesis;Angiogenic Factor;Angioplasty;Animal Experimentation;Animals;Arteries;artery occlusion;Atherectomy;Atherosclerosis;Biodistribution;Biological;Biological Assay;Blood;Blood capillaries;Blood flow;Blood Tests;Blood Vessels;Bypass;Caring;Cell Adhesion Molecules;Cell Communication;Cell Physiology;Cells;Cellular Morphology;Clinical;Clinical Trials;clinically relevant;critical limb Ischemia;Data;delivery vehicle;Development;Diagnosis;Disease;Docking;Dose;E-Selectin;efficacy validation;endogenous stem cells;Endothelial Cells;endothelial stem cell;experience;Face;Fibrin fragment D;Fibroblast Growth Factor;Foundations;Funding;Future;Gangrene;Gene Delivery;gene delivery system;gene therapy;Generations;Goals;Harvest;healing;Health Care Costs;high risk;Homing;Human;human study;immune cell infiltrate;improved;In Vitro;in vivo;Inflammation;innovation;intercellular communication;Intervention;Ischemia;Isolated limb perfusion;Ligands;limb amputation;limb ischemia;limb loss;Limb Salvage;Limb structure;liver function;Long-Term Effects;manufacture;Mechanics;Medical;Metabolic;Modeling;mortality risk;mouse model;Mus;Muscle Cells;Muscle Fibers;National Heart, Lung, and Blood Institute;Natural regeneration;neovascularization;non-healing wounds;novel;novel therapeutics;Organ;Pain;Pain in lower limb;Paracrine Communication;Pathologic;Patients;Peripheral arterial disease;Phase;Physical Function;Pilot Projects;Plasmids;preclinical study;prevent;Process;progenitor;Protocols documentation;Quality of life;Recovery;recruit;regenerative;regenerative cell;Renal function;repaired;Research;Rest;revascularization;Running;Safety;Salvage Therapy;scale up;Serum;Site;Skeletal Muscle;skin ulcer;stability testing;Stains;stem cells;Stents;Structure;success;systemic toxicity;Testing;Therapeutic;therapeutic angiogenesis;Therapeutic Effect;Thrombosis;tissue regeneration;tissue repair;Tissues;Toxic effect;Transgenes;translational research program;treadmill;treatment optimization;Vascular Endothelial Growth Factors;vector;Viral;Walking;Work

PROJECT_TITLE: Novel Gene Therapy for Critical Limb Ischemia and Limb Salvage in Vascular Occlusive Disease


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Prevention

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

ORG_STATE: CA

PHR: Autism spectrum disorder (ASD) is caused by both environmental and genetic factors, but most of the genes responsible for ASD remain unknown, and the functions of most ASD risk genes that have been identified are poorly understood. We will use zebrafish as a vertebrate model system to study the effects of a large number of recently-identified ASD risk genes on brain development and behavior. These studies will improve our understanding of why mutations in specific genes result in ASD and may ultimately lead to novel therapies.

PI_NAMEs: GESCHWIND, DANIEL H;PROBER, DAVID AARON (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Acceleration;Address;Animal Model;autism spectrum disorder;Autopsy;Behavior;behavior test;Behavioral;Behavioral Model;behavioral phenotyping;Biological Assay;Biological Models;Brain;Cells;cohort;Communities;comorbidity;cost;cost effectiveness;Data;data integration;de novo mutation;Development;Disease;disease model;disorder risk;Drug Screening;experimental study;Gene Expression;gene function;gene network;Genes;Genetic;genetic risk factor;genome sequencing;genome wide association study;genome-wide;Goals;habituation;high throughput analysis;high throughput screening;high-throughput drug screening;Human;Image;imaging approach;improved;in vivo;Individual;Inherited;Literature;Methods;Missense Mutation;model of autism spectrum disorder;model organism;Modeling;Molecular;molecular phenotype;mutant;Mutation;neurodevelopment;Neurons;novel;novel therapeutic intervention;novel therapeutics;null mutation;Orthologous Gene;Pathway Analysis;Pathway interactions;pharmacologic;Phenotype;Protein Truncation;Publishing;Reagent;relative effectiveness;Reporting;Resources;Risk;risk variant;RNA Splicing;Role;screening;Seizures;Signal Transduction;Sleep;Sleep disturbances;social;Social Behavior;Spliced Genes;Startle Reaction;System;Testing;Time;Tissue-Specific Gene Expression;transcriptomic profiling;transcriptomics;Translating;translational goal;Variant;Vertebrates;whole genome;Zebrafish

PROJECT_TITLE: High-throughput modeling of autism risk genes using zebrafish

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Obesity;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: BARCELONA

ORG_COUNTRY: SPAIN

ORG_FIPS: SP

ORG_NAME: FUNDACIO INSTITUT DE RECERCA BIOMEDICA

PI_NAMEs: LOPEZ-BIGAS, NURIA  (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Address;Aging;Alcohol consumption;anti-cancer research;Architecture;Bioinformatics;Biological;Biological Models;Body Weight decreased;Breast;Cancer Etiology;Cancer Model;cancer prevention;cancer risk;carcinogenesis;Cells;cellular targeting;chemical property;chemotherapy;Clonal Evolution;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Colorectal;Communities;Country;CRISPR screen;Data;data integration;Data Set;detection method;Development;DNA;driver mutation;Endogenous Factors;Endometrial;Environment;environmental agent;Environmental Risk Factor;Epidemiology;epidemiology study;Epigenetic Process;epigenomics;Epithelial Cells;Event;Excision;experience;Exposure to;Gene Expression;Generations;Genetic;genome-wide;Genomics;Goals;hematopoietic tissue;High-Risk Cancer;Human;human tissue;immune cell infiltrate;in vivo Model;Individual;Inflammation;inhibitor;innovation;Institutional Review Boards;Intervention;Intervention Studies;Investigation;Life Style;lifestyle factors;Limited Stage;Link;Machine Learning;Malignant - descriptor;Malignant Neoplasms;Maps;Measures;Methods;Modeling;Molecular;Molecular Target;mouse model;multidisciplinary;Mus;Mutate;Mutation;Neoplasms;neoplastic;Normal Cell;Normal tissue morphology;novel;Obesity;Organoids;Pathway Analysis;Pathway interactions;Pattern;Phenotype;Population;Prevalence;Process;promoter;Proteome;Proteomics;Research Personnel;response;Risk;Risk Factors;Role;Route;Sampling;small molecule;smoking cessation;stem;stem cells;Structure of parenchyma of lung;Testing;Time;Tissue Donors;Tissue imaging;Tissue Sample;Tissues;tool;transcriptomics;tumor;Tumor Promoters;Tumor Promotion;Tumor stage;Tumor Tissue;tumorigenesis;Unhealthy Diet;whole genome

PROJECT_TITLE: PROMINENT - IRB


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: The proposed work is relevant to public health because the discovery of molecular mechanisms of Rhes- SUMO mediated cell-type specific role and interneuronal transport of cargo in animal models is ultimately expected to increase understanding of mechanisms of Rhes-SUMO signaling in neurological disorders, as well as provide framework for developing novel therapeutic strategies, based on novel mechanisms-based approaches. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to acquiring basic insights that will aid to lessen the pain of human of disability.

PI_NAMEs: SUBRAMANIAM, SRINI  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Actins;Address;Affect;Aging;Anatomy;Animal Diseases;Animal Model;Animals;Area;Atrophic;Autophagocytosis;Behavior;Behavioral;Binding;Brain;Brain Diseases;Brain region;cell type;Cells;Corpus striatum structure;Cultured Cells;Data;disability;Disease;disease model;Disease Progression;Distant;DRD2 gene;drug discovery;Energy Metabolism;Etiology;expression vector;farnesylation;Genetic Diseases;Genetic Transcription;Glutamine;Homologous Gene;Human;Huntington Disease;Huntington gene;In Vitro;in vivo;Inflammation;inhibition of autophagy;inhibitor;insight;Interneurons;Knock-in Mouse;Knowledge;Link;live cell imaging;Mass Spectrum Analysis;Mediating;Membrane;Mission;Modification;Molecular;Mus;mutant;Nanotubes;Nervous System Disorder;Neuroglia;Neurons;neuropathology;new therapeutic target;novel;novel therapeutic intervention;Onset of illness;Oxidative Stress;Pain;Pathogenesis;Pathway interactions;Peripheral;pharmacologic;Phenotype;polyglutamine;Post-Translational Protein Processing;prevent;Process;Proteins;Public Health;ras Proteins;Reporter;Research;Role;Route;Signal Transduction;Slice;Specificity;SUMO1 gene;Sumoylation Pathway;Synapses;Testing;Tissues;Toxic effect;Transgenic Animals;transmission process;Transportation;Ubiquitin;United States National Institutes of Health;Viral Vector;white matter;Work

PROJECT_TITLE: Rhes-SUMO Pathway in Huntington disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Although fever and pneumonia are the most common symptoms in patients with COVID-19, some patients also show neurological symptoms, including the loss of smell and severe headache or seizure. Little is known about whether SARS-CoV-2 can infect the nervous system or cause neuroinflammation. By investigating the neurological effects of COVID-19, using human studies and mouse models, this project will help uncover novel aspects of SARS-CoV-2 related neuro-pathophysiology and elucidate important factors to consider when treating COVID-19 patients.

PI_NAMEs: FARHADIAN, SHELLI ;IWASAKI, AKIKO  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: 2019-nCoV;ACE2;adeno-associated viral vector;Affect;Anosmia;Antibodies;antigen detection;associated symptom;Ataxia;Attenuated;Autopsy;biobank;Biology;Blood;Brain;Brain Stem;brain tissue;Cardiopulmonary;Case Series;Cells;Central Nervous System;Central Nervous System Infections;central nervous system injury;Cerebrospinal Fluid;China;Circulation;common symptom;Communities;Coronavirus;coronavirus disease;COVID-19;COVID-19 diagnosis;COVID-19 impact;COVID-19 pandemic;COVID-19 patient;COVID-19 treatment;cytokine;Data;detection assay;Disease;Dose;Encephalopathies;Enrollment;Europe;Evaluation;Family member;Fever;Flow Cytometry;Functional disorder;Gene Modified;Goals;Headache;Health;Heart;Heart Hypertrophy;Histology;Histopathology;Hospitalization;Human;human tissue;Hypertension;Hypogeusia;Hypoxemia;Immune;immune cell infiltrate;Immune response;immunoreaction;Impairment;Individual;Infection;Inflammatory;Inflammatory Response;influenzavirus;insight;Institutional Review Boards;interest;Intractable Headaches;Invaded;Investigation;Knockout Mice;Lung;Lung infections;Maps;Measurement;Mediating;Modeling;Monitor;monocyte;mortality;mouse model;Mus;Nervous System;Nervous System Disorder;Nervous System Trauma;neuroinflammation;Neurologic;Neurologic Effect;Neurologic Symptoms;Neurological Models;neuron loss;Neurons;neuropathology;neurotropic;Neurotropism;novel;novel coronavirus;Olfactory dysfunction;Outcome;overexpression;Pathogenicity;Pathology;Pathway interactions;patient subsets;Patients;Physiological;Plaque Assay;Plasma Cells;Pneumonia;Population;Process;Production;Protocols documentation;Pulmonary Heart Disease;Pulmonary Pathology;pulmonary symptom;receptor;Reporting;Respiration Disorders;respiratory;Respiratory Disease;Respiratory Failure;Respiratory Tract Infections;response;Role;Sampling;SARS coronavirus;SARS-CoV-2 infection;Secondary to;Seizures;single cell genomics;single-cell RNA sequencing;Smell Perception;Spinal Puncture;Stains;Structure of parenchyma of lung;Study models;success;Supporting Cell;Symptoms;Taste Perception;Tissues;Toxic effect;Validation;Viral;viral detection;Virus;Wild Type Mouse

PROJECT_TITLE: Viral and immune-mediated CNS pathology during SARS-CoV-2 infection


ADMINISTERING_IC: FD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: CONWAY

ORG_NAME: ARKANSAS RESEARCH ALLIANCE

ORG_STATE: AR

PHR: Project Narrative The FDA ability to protect the public health is directly related to its ability to access and utilize the latest scientific data. Increased proficiency in collecting, presenting, validating, understanding, and drawing quantitative inference from the massive volume of new scientific results is necessary for success in that effort. The complexity involved requires continued development of new tools available and being developed within the realm of information technology, and the workshops proposed here will address this need. Specific Aims  • Thoroughly understand the resources in Arkansas available for furthering the capabilities in  bioinformatics and its associated needs, e.g., access to high speed computing capability and use  of computational tools. • Develop a set of plans to harness and grow those capabilities, especially those that are relevant  to the needs of NCTR and FDA. • Stimulate interest and capability across Arkansas in bioinformatics to produce a larger cadre of  expertise as these plans are implemented. • Enlist NCTR’s help in directing the effort toward seeking local, national and international data  that can be more effectively analyzed to produce results needed by FDA and others, e.g.,  reviewing decades of genomic/treatment data on myeloma patients at the University of  Arkansas for Medical Sciences. • Develop ways in which the Arkansas capabilities can be combined into a coordinated, synergistic  force larger than the sum of its parts. • Encourage students and faculty in the development of new models and techniques to be used in  bioinformatics and related fields. • Improve inter-institutional communication, including developing standardized bioinformatics  curricula and more universal course acceptance.

PI_NAMEs: BARNHOUSE, BRYAN  (contact)

PROGRAM_OFFICER_NAME: OVERTON, KYLE

PROJECT_TITLE: Arkansas Bioinformatics Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 NCTR-T (02)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Depression;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: Los Angeles

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE  Social connection during pregnancy is a well-established buffer for prenatal stress known to predict better infant and maternal health in the postpartum period. This study examines how social disruption, particularly during the COVID-19 pandemic, affects expectant parents and their subsequent mental health, birth outcomes, and infant development.

PI_NAMEs: SAXBE, DARBY E. (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Affect;Age;Anxiety;Anxiety Disorders;anxiety symptoms;Apgar Score;Behavior;Behavioral;biopsychosocial factor;Birth;Birth Weight;Buffers;Child;Child Health;Child Rearing;Childbirth;cohort;Communities;Coronavirus;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Reporting;Data Set;depressive symptoms;Development;Disease;Distress;Economics;Enrollment;Expectancy;experience;Extended Family;Family health status;Fathers;Feeling;Fetal Development;follow-up;Foundations;Fright;Funding;Geographic Locations;Gestational Age;Guidelines;Hair;Health;healthy pregnancy;Height;Hospitals;Hydrocortisone;in utero;Incidence;indexing;Infant;Infant Development;Infant Health;infant temperament;Infection;insight;Knowledge;Link;Location;Loneliness;Long-Term Effects;Low Birth Weight Infant;Maternal Health;Measures;Mental Depression;Mental Health;Modeling;Mood Disorders;Mothers;National Institute of Child Health and Human Development;Natural experiment;neurodevelopment;neuroimaging;Neurosecretory Systems;Outcome;pandemic disease;pandemic impact;Parents;Participant;Patient Self-Report;perceived stress;Personal Satisfaction;Persons;Population;postpartum outcome;Postpartum Period;pre-pandemic;Pregnancy;Pregnant Women;Premature Birth;prenatal;Prenatal care;prenatal stress;protective factors;psychological distress;Readiness;Recovery;recruit;Reporting;Research;resilience;Risk;Risk Factors;Sampling;Schools;Shapes;social;Social Behavior;Social Distance;social factors;Social support;Source;stay-at-home order;Strategic Planning;Stress;stress management;stressor;Temperament;Testing;United States;Woman

PROJECT_TITLE: Prenatal Social Connection and Disruption During the COVID-19 Pandemic: Effects on Maternal and Infant Health


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The goal of this proposal is to advance the cardiovascular health of women affected by hypertensive disorders of pregnancy (HDP) by 1) studying the association of urban/rural residence and socioeconomic status on the incidence, cardiometabolic outcomes, and post-partum care access across HDP subtypes and 2) conducting qualitative interviews to identify related social determinants of health barriers in rural settings for future targeted intervention in a large, multi-site, and largely rural practice in the Midwest.

PI_NAMEs: KATTAH, ANDREA G (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: acute care;Acute Renal Failure with Renal Papillary Necrosis;Adherence;adverse outcome;adverse pregnancy outcome;Affect;Age;Area;barrier to care;Biomedical Research;Body System;cardiometabolic risk;cardiometabolism;Cardiomyopathies;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Caring;Censuses;Characteristics;Chronic;comorbidity;Cost Analysis;Cost Savings;County;Data;Demographic Factors;deprivation;Diabetes Mellitus;Diagnosis;Disease;disparities in women;Disparity;effective intervention;Electronic Health Record;Emergency department visit;Epidemiology;Ethnic Origin;follow-up;Future;Goals;Health;health belief;Health Sciences;Health Services Accessibility;High Prevalence;high risk;high risk population;High Risk Woman;hospital readmission;Housing;Hyperlipidemia;Hypertension;improved;Incidence;indexing;Individual;innovation;Intervention;Intervention Studies;Interview;low socioeconomic status;Maternal Mortality;Measures;Midwestern United States;Modeling;Morbidity - disease rate;novel;obstetric services;Organ;Outcome;Patient Self-Report;Patients;Play;Population;post pregnancy;postpartum care;Postpartum Period;Pregnancy;Pregnancy Complications;pregnancy disorder;pregnancy hypertension;Pregnancy Outcome;Race;Recommendation;reproductive;Research;residence;Resources;Risk;Risk Factors;Role;Rural;rural area;Rural Community;rural counties;rural disparities;rural patients;Rural Population;rural residence;rural setting;Sampling;severe maternal morbidity;Site;social health determinants;social vulnerability;Socioeconomic Factors;Socioeconomic Status;Standardization;Strategic Planning;Stroke;Structure;Testing;Thromboembolism;United States National Institutes of Health;urban area;Visit;Woman;Women's Health;Work

PROJECT_TITLE: The Role of the Urban/Rural Divide and Socioeconomic Factors in the Incidence, Outcomes and Post-partum Care of Hypertensive Disorders of Pregnancy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-J(96)S]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Immunotherapy;Lung;Neurosciences;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The recent COVID-19 pandemic highlighted the critical unmet need for effective treatments for acute respiratory distress syndrome (ARDS) that would mitigate not only against lung injury but also ARDS-associated brain injury. We will test a novel approach to treat both lung and brain injury in ARDS with intravenously administered naïve B cells. We propose that B cells migrate into the sites of injury where they suppress inflammation and promote healing.

PI_NAMEs: HANIDZIAR, DUSAN  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acceleration;Acute Respiratory Distress Syndrome;Adenosine;Adopted;adoptive B cell transfer;Adoptive Transfer;Allogenic;Animal Model;Anti-Inflammatory Agents;Apoptosis;B cell therapy;B-Lymphocyte Subsets;B-Lymphocytes;Blood Vessels;Brain;Brain Injuries;brain tissue;Caspase;CD44 gene;Cell Death;cell motility;Cells;Clinical;clinical practice;clinical translation;COVID-19 pandemic;cytokine;Data;Dependence;diabetic;Dose;effective therapy;Ensure;experimental study;Future;Goals;healing;Histologic;Histology;Home;Homing;Hour;Hyperoxia;IL17 gene;Imaging Device;Immune;immunoregulation;Infiltration;Inflammasome;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Injury;Interferon Type II;Interleukin-1 beta;Interleukin-10;interstitial;Intravenous;intravenous administration;Knock-out;Location;Lung;lung injury;Lymphoid Tissue;Macrophage;Memory;Memory B-Lymphocyte;Microglia;Mitochondria;mitochondrial dysfunction;molecular imaging;mouse model;Mus;Myeloid Cells;Myocardial Infarction;neurobehavioral;neuroinflammation;Neurologic;Neurological outcome;Neuronal Injury;neuroprotection;neutrophil;Neutrophil Infiltration;new therapeutic target;novel;novel strategies;Organ;Outcome;Oxygen;Pathogenicity;Pathway interactions;Patients;PET/CT scan;Phenotype;Population;Production;protective effect;Reporting;Research;respiratory;response;Rodent Model;Sepsis;serial imaging;Severities;Site;skin ulcer;Structure of parenchyma of lung;Survivors;Testing;tissue injury;Tissues;trafficking;Transforming Growth Factor beta;translational impact;translational therapeutics;Traumatic Brain Injury

PROJECT_TITLE: B cells for treatment of ARDS

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Our study will provide a better understanding of mechanisms of acute promyelocytic leukemia-associated coagulopathy and bleeding. We will also have explored new treatments for acute promyelocytic leukemia- associated bleeding and acute promyelocytic leukemia itself. In addition, our study may find new biomarkers to identify acute promyelocytic leukemia patients at high risk of bleeding using omics techniques.

PI_NAMEs: HISADA, YOHEI M (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Acute Myelocytic Leukemia;Acute Promyelocytic Leukemia;acute promyelocytic leukemia cell;Allografting;Annexins;Antibodies;Antibody-drug conjugates;Antiplasmin;antithrombin III-protease complex;Biological Markers;Blast Cell;Blood Coagulation Disorders;Blood Coagulation Factor;Blood Platelets;C-Type Lectins;Cells;Cessation of life;chemotherapy;Coagulation Process;Complex;Consumption;Diagnosis;Differentiation Therapy;Disseminated Intravascular Coagulation;Exhibits;Failure;FDA approved;Fibrin;Fibrin fragment D;Fibrinolysis;Goals;Hemorrhage;Hemostatic Agents;high risk;Incidence;Individual;Modeling;monocyte;mouse model;neoplastic cell;Observational Study;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Pharmacologic Substance;Plasma;Plasmin;podoplanin;Predisposition;prevent;Proteome;receptor;Role;System;Techniques;Testing;therapeutic target;Thrombocytopenia;Thromboplastin;Tranexamic Acid;transcriptome;Urokinase;Urokinase Plasminogen Activator Receptor;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Mechanisms of coagulopathy and bleeding in acute promyelocytic leukemia

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Lung;Machine Learning and Artificial Intelligence;Pulmonary Hypertension

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

ORG_STATE: TX

PHR: NARRATIVE Right ventricular-arterial uncoupling is strongly associated with poor outcomes in patients with pulmonary hypertension. Significant changes in both passive stiffness and contractile characteristics of the right ventricle are evident in pulmonary hypertension patients, and the competition between these changes is expected to result in either the preservation or loss of ventricular-arterial coupling. The studies proposed in this application investigate the stiffness-to-contractility ratio as a novel biomechanical marker that predicts the ability of the right ventricle to preserve ventricular-arterial coupling. Further, the proposed studies develop and validate an integrated artificial intelligence-echocardiography technology to feasibly quantify this marker in vivo and use it to identify patients at risk of ventricular-arterial uncoupling in settings of pulmonary hypertension.

PI_NAMEs: AVAZMOHAMMADI, REZA  (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Animals;Architecture;arterial remodeling;Artificial Intelligence;Biomechanics;Characteristics;Clinical;Collagen;Coupling;Cross-Sectional Studies;Data;deep learning;deep learning model;Diffusion Magnetic Resonance Imaging;Disease;Distal;Early identification;Echocardiography;Elements;Event;Fiber;Fibrosis;functional outcomes;Generations;Histologic;Human;human data;Image;improved;in silico;in vivo;Individual;longitudinal analysis;Lung;Measures;Mechanics;Medical center;Modeling;Muscle;novel;Organ;Outcome;Patients;pre-clinical;preclinical study;predictive marker;Predictive Value;preservation;pressure;Prognostic Marker;Property;Pulmonary Hypertension;Pulmonary Vascular Resistance;Rattus;Resistance;Right Ventricular Dysfunction;Right Ventricular Function;right ventricular remodeling;Right ventricular structure;Risk;risk stratification;Rodent Model;Role;Side;Technology;Testing;Therapeutic Studies;Tissues;tool;Translating;Ventricular

PROJECT_TITLE: Role of right ventricular passive remodeling in ventricular-arterial uncoupling in pulmonary hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Genetics;Hematology;Lung;Pulmonary Hypertension;Rare Diseases;Sickle Cell Disease

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Pulmonary complications are the most common cause of death in patients with sickle cell disease and are thought to be caused by the release of toxins during the breakdown of red blood cells. This proposal expands on our previous work to identify the role of hemin, a toxin released during breakdown of red blood cells, in the development of these pulmonary complications, namely pulmonary hypertension and acute chest syndrome. We use preclinical models as well as genomic data from sickle cell disease patients to better understand these deadly complications in order to develop new therapies.

PI_NAMEs: FRAIDENBURG, DUSTIN  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Acute;acute chest syndrome;Acute Lung Injury;Animal Model;Blood Transfusion;Blood Vessels;Body System;Cause of Death;Cell Death;Cell model;Cells;Characteristics;Chronic;clinical care;cohort;Complement;Complication;Cytoskeleton;Data;Development;Diagnosis;differential expression;Disease;Endothelial Cells;endothelial dysfunction;Endothelium;Erythrocytes;Etiology;Event;Exposure to;extracellular;Functional disorder;Genetic;genetic signature;genomic data;genomic signature;Goals;Health;Heme;Hemin;Hemoglobin;Hemolysis;Hemolytic Anemia;Hospitalization;Human;hydroxyurea;Hypoxia;In Vitro;in vivo;Incidence;Individual;Inflammation;Inflammatory;Injury;Innovative Therapy;Lead;Lung;lung injury;Mesenchymal;migration;Molecular;molecular marker;Molecular Target;Morbidity - disease rate;mortality;mortality risk;Necrosis;non cardiogenic pulmonary edema;novel;novel therapeutics;Pathway interactions;Patients;Pattern;Phenotype;Phosphotransferases;Plasma;Play;Population;Pre-Clinical Model;Process;Property;protein expression;Protein Kinase Interaction;pulmonary artery endothelial cell;Pulmonary Circulation;Pulmonary Hypertension;pulmonary vascular disorder;pulmonary vascular remodeling;Receptor Activation;Research;Respiratory Failure;Rodent Model;Role;Severities;Sickle Cell Anemia;Signal Transduction;survivorship;Syndrome;Technology;Testing;therapeutic target;Time;TLR4 gene;Toxin;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;transdifferentiation;translational approach;Vascular remodeling;White Blood Cell Count procedure;Work

PROJECT_TITLE: Diverse effects of hemin on the endothelium contribute to pulmonary complications of sickle cell disease


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The most common form of congenital heart disease in children involves incomplete division of the ventricles, known as ventricular septal defects. We have identified a cell population in the early embryo that contributes to the formation of the septa between ventricular heart chambers and forms a cell boundary to prevent mixing of cells between the left ventricle and the right ventricle. We will study how two candidate pathways control this boundary for L-R patterning of the interventricular septum, and how disruptions lead to ventricular septal defects.

PI_NAMEs: KATHIRIYA, IRFAN S (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Adhesions;Biological Assay;Blood Vessels;Candidate Disease Gene;Cardiac;cardiac repair;cell motility;Cell Separation;cell type;Cells;Chemotaxis;Child;Collagen;Complex;Comprehension;congenital heart abnormality;Cues;Data;Defect;Development;Embryo;Etiology;Evaluation;Exclusion;Fiber;Gel;Gene Expression;Genes;Genetic;Genetic Markers;Goals;Heart;Heart failure;Human;improved;Infant;insight;Knowledge;Lead;Left;Left ventricular structure;Lesion;Ligands;Link;loss of function;Machine Learning;Maintenance;Modeling;Molecular;morphometry;Mus;Muscle;mutant;Mutation;Myocardial;Natural History;neural;NTN1 gene;Operative Surgical Procedures;Outcome;overexpression;Pathway interactions;Pattern;Population;Positioning Attribute;prenatal testing;preservation;prevent;Prognosis;receptor;Regulation;repaired;Right ventricular structure;Role;segregation;Side;Signal Transduction;single-cell RNA sequencing;Structure;Testing;Tissue Engineering;Tissues;transcription factor;transcriptomics;Transgenes;Ventricular;Ventricular Septal Defects;Ventricular septum;Work

PROJECT_TITLE: Patterning Mechanisms for Ventricular Septation and Congenital Heart Disease

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


PHR: 8. PROJECT NARRATIVE The Centers of Excellence in Regulatory Science and Innovation (CERSI) program allows the U.S. Food and Drug Administration (FDA) to form extramural partnerships that foster robust and innovative research to develop new tools, standards, and approaches to assess the safety, efficacy, quality, and performance of FDA- regulated products, supporting regulatory decision-making and the overall mission of the FDA. Over the past seven years, the Yale-Mayo Clinic CERSI has pursued a series of innovative research projects that leverage real-world data sources to assess the safety, efficacy, quality, and performance of FDA-regulated products, informing regulatory decision-making as well as manufacturers, clinicians, and patients in support of optimizing patient-centered care, along with providing and supporting high-quality mentorship and training in regulatory science. The Yale-Mayo Clinic CERSI will continue this work, conducting high-quality, high-impact regulatory science research in priority areas identified by the FDA to modernize development and evaluation of FDA- regulated products, strengthen post-market surveillance and labelling of FDA-regulated products, and invigorate public health preparedness and response of FDA, patients, and consumers.

PI_NAMEs: ROSS, JOSEPH SOLOMON (contact)

PROGRAM_OFFICER_NAME: BATTLES, JESSICA JOY

PROJECT_TITLE: Yale-Mayo Clinic FDA Center of Excellence in Regulatory Science and Innovation (CERSI)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: RICE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed study will collect longitudinal data from 450 Latino immigrant adults varying in context of migration to examine how exposure to food insecurity and trauma – concurrently and prospectively influence risk for cardiovascular disease (CVD) and diminished psychological well-being via the biological pathways of malnutrition and systemic inflammation, along with identifying individual and cultural protective factors. Using state-of-the-art biomarkers and mixed methods, this is the first study to identify multi-domain, multi-level factors that promote resilience in this immigrant population at the biological level, as well as qualitatively, and therefore takes first steps towards the development of novel therapeutics to address disparities in CVD and psychological well-being among Latino immigrants. Knowledge gained from this study will propel scientific evidence about biobehavioral mechanisms through which food insecurity influences health risk and contributes to health disparities, as well as inform culture and context sensitive assessments, prevention efforts, interventions, and policies for a marginalized immigrant population about which little is known.

PI_NAMEs: GARCINI, LUZ MARIA (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Acculturation;Acute;Address;Adult;Advocacy;Age;Behavioral;biobehavior;Biological;Biological Markers;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Chronic;Chronic stress;Collaborations;Communities;community partners;comparison group;Cultural Backgrounds;cytokine;Data;Development;dietary;Dimensions;Disadvantaged;Disparity;Emotions;experience;Exposure to;Food;food insecurity;Fostering;Health;health disparity;hypothalamic-pituitary-adrenal axis;Immigrant;Immigration;Individual;Inflammation;Inflammatory;Inflammatory Response;innovation;Intervention;Knowledge;Latino;Link;Literature;longitudinal, prospective study;Malnutrition;marginalization;Mediating;Methods;Mexico;Migrant;migration;Modeling;Neurosecretory Systems;novel;novel therapeutics;nutrition;Nutritional status;Participant;Pathway interactions;Pattern;Policies;Population;Prevention;Production;promote resilience;prospective;protective factors;psychologic;Psychological Stress;Public Health;Recording of previous events;recruit;Research;Research Design;resilience;Resources;Risk;Scientist;sex;Shelter facility;Side;social culture;social determinants;social health determinants;Stress;stressor;systemic inflammatory response;Time;Trauma;Well in self;Work

PROJECT_TITLE: A biobehavioral Approach to Explore the Migration-food Insecurity Nexus as a Social Determinant of Cardiovascular Health

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative  Investigating the mechanism that leads to the development of long-term lung epithelium alteration after early-life RSV infection, which is explored in this proposal, will establish new paradigms that will be crucial for understanding how RSV infection predispose to asthma and develop new interventional therapies that attenuate RSV disease severity and the predisposition to childhood asthma. This application proposes highly innovative ideas to advance RSV immunopathology and asthma research.

PI_NAMEs: FONSECA AGUILAR, WENDY  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Adult;Airway Disease;airway epithelium;Allergens;allergic airway disease;Allergic Disease;Allergic Reaction;allergic response;alveolar epithelium;Area;Asthma;asthmatic airway;Attenuated;Biological Response Modifiers;Bronchiolitis;Cell Physiology;Cells;Child;Childhood;Childhood Asthma;Chromatin;Chronic;cytokine;Data;Development;Disease;Eosinophilia;Epigenetic Process;Epithelial Cells;Epithelium;Extrinsic asthma;Feedback;Genes;Genome;histone modification;Hospitalization;Hypersensitivity;IgE;Immune;Immune response;Immunity;immunopathology;infancy;Infant;Infection;Inflammatory Response;innovation;Interleukin-1;Life;Link;Lung;Lung Diseases;mast cell;Modification;Molecular;Mus;neonatal mice;novel;pathogen;Pathway interactions;Phenotype;Predisposition;prevent;Production;promoter;Publishing;pulmonary function;Research;respiratory;Respiratory Signs and Symptoms;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;response;Risk;Risk Factors;Role;Severity of illness;Signal Pathway;Signal Transduction;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;TSLP gene;Type II Epithelial Receptor Cell;Up-Regulation;Vaccines;Virus Diseases

PROJECT_TITLE: Long-term alteration of the airway epithelium after early life RSV infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RCCS-E(03)]


NIH_SPENDING_CATS: Hematology;Physical Injury - Accidents and Adverse Effects

ORG_CITY: LOS ANGELES

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative In patients with open heart surgery and organ transplant, an enzyme called plasmin breaks down blood clots and contributes significantly to bleeding. In high risk cardiac surgery, inhibition of plasmin by its inhibitor bovine aprotinin was very successful, but this drug is discontinued as it caused severe organ damage. Studies proposed in this application have the potential to develop a substitute for aprotinin and lysine analogs, which would be more efficacious, safe and of human origin.

PI_NAMEs: VADIVEL, KANAGASABAI  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: activated Protein C;Active Sites;Acute;Address;Adverse effects;Affinity;Alteplase;Amino Acids;Amputation;Antifibrinolytic Agents;Aprotinin;Area;Attenuated;Binding;Biochemical;Biology;Blood coagulation;Blood Coagulation Disorders;Blood Coagulation Factor;Blood Platelets;Blood Vessels;C-terminal;Cardiac Surgery procedures;Cardiovascular Surgical Procedures;Cattle;Cells;Chronic;Coagulation Process;Complex;Data;data modeling;Defect;design;Development;Dose;efficacy evaluation;efficacy study;Endothelial Cells;Enzymes;FDA approved;Fibrinolysis;Goals;Hemorrhage;Hemostatic Agents;high risk;Histologic;Homeostasis;Homologous Gene;Human;Impairment;improved;in vivo;inhibitor;Injury;Investigation;Kininogenase;Kringles;Laceration;Liver;Lysine;lysine analog;Marketing;Megakaryocytes;Microcirculation;Modeling;molecular modeling;mortality;mortality risk;mouse model;Mus;Mutagenesis;mutant;Mutation;N-terminal;Neurologic;novel;operation;Operative Surgical Procedures;Organ;organ injury;Organ Transplantation;Orthopedics;Outcome;Pathologic;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Physiological;Plasma;Plasma Kallikrein;Plasmin;Plasmin Inhibitor;Plasminogen;Positioning Attribute;prevent;Property;Protease Inhibitor;Rattus;Recovery;Reducing Agents;Safety;safety assessment;safety study;safety testing;Saline;Seizures;Serine Protease;Serine Proteinase Inhibitors;Smooth Muscle Myocytes;Specificity;Structure;Substrate Specificity;Syncytiotrophoblast;Tail;Testing;TFPI;Therapeutic Agents;Thrombin;Thrombomodulin;Thromboplastin;tissue-factor-pathway inhibitor 2;Toxic effect;Transfusion;Trauma;Trauma patient;treatment group;Urokinase;Variant;Whole Blood

PROJECT_TITLE: Structure and Biology of Tissue Factor Pathway Inhibitor-2


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Cardiovascular;Clinical Research;Data Science;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

PHR: Project Narrative Clonal Hematopoiesis of Indeterminate Potential (CHIP) is a condition of aging and is associated with increased risk of heart disease, heart failure and worse outcomes in cancer patients. CHIP involves somatic mutations in peripheral blood stem cells and currently can only be evaluated by DNA sequencing of blood. The proposed research will use cutting edge machine learning methods to elucidate unique imaging features in cardiac MRI to identify subjects with CHIP, predict who with CHIP will develop cardiomyopathy as well as integrate MRI, genomics and transcriptomics to identify pathways contributing to cardiomyopathy and potential personalized therapeutic targets.

PI_NAMEs: KWAN, JENNIFER M (contact)

PROGRAM_OFFICER_NAME: HSU, LI-YUEH

PROJECT_TERMS: adverse outcome;Age;Aging;Algorithms;analysis pipeline;Arterial Fatty Streak;Artificial Intelligence;Attention;biobank;Biology;Blood;Blood Cells;Cancer Patient;Cancer Survivor;Cardiac;cardiac magnetic resonance imaging;cardiac tissue engineering;Cardiomyopathies;cardiovascular risk factor;Cardiovascular system;Cells;Cicatrix;Clonal Expansion;cohort;convolutional neural network;coronary fibrosis;cytokine;Data;Data Set;deep learning;deep learning algorithm;DNA sequencing;DNMT3a;Epigenetic Process;Etiology;Evaluation;experimental study;Fibrosis;Future;Gadolinium;Genes;Genetic;genetic variant;genomic signature;Genomics;Heart;heart disease risk;Heart failure;heart function;heart imaging;Hematopoiesis;hematopoietic stem cell expansion;high risk;Human Engineering;Image;image guided;Impairment;Individual;Inflammatory;innovation;insight;Invaded;Ischemia;large datasets;large-scale imaging data;Lead;Machine Learning;machine learning method;Macrophage;Magnetic Resonance Imaging;Malignant Neoplasms;Mediating;Methods;Modeling;Molecular;Monitor;mutant;Myocardial Infarction;neural network;new therapeutic target;novel;Oncology;Outcome;outcome prediction;Pathway Analysis;Pathway interactions;Patients;peripheral blood;Peripheral Blood Stem Cell;personalized predictions;personalized therapeutic;Physiological;Population;predictive modeling;Prevalence;Prognosis;prognostic value;Research;Risk;Risk Management;Risk Reduction;risk stratification;Role;Serum;Single Nucleotide Polymorphism;Solid;Somatic Mutation;Standardization;Systolic heart failure;Techniques;therapeutic target;Tissues;Toxic effect;Training;Trans-Omics for Precision Medicine;transcriptomics;Weight

PROJECT_TITLE: Personalized Prediction of Cardiovascular Outcomes through Machine Learning Analysis of Cardiac MRI and Genomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-N(90)S]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Sleep Research;Social Determinants of Health;Telehealth

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE Despite decades of research documenting the benefits of continuous positive airway pressure (CPAP) therapy, this highly effective treatment is not initiated, implemented, or persistently used by the millions of adults worldwide diagnosed with obstructive sleep apnea (OSA) The overall objective of the proposed project is to evaluate a telehealth-delivered adaptive intervention for persons newly diagnosed with OSA that promotes CPAP adherence and improves health outcomes and assess potential mediators and moderators of treatment response. By using an innovative adaptive design and telehealth-delivered approach, study results will directly lead to a more personalized approach to increasing long-term CPAP adherence and improving health outcomes of persons with OSA while simultaneously generating a better understanding of factors that drive CPAP adherence across a variety of personal, social, and economic contextual factors.

PI_NAMEs: MILLER, JENNIFER NICOLE (contact)

PROGRAM_OFFICER_NAME: BROWN, MARISHKA

PROJECT_TERMS: acceptability and feasibility;adaptive intervention;Adherence;Adult;alternative treatment;behavior change;Behavioral;Categories;Clinical;Cognition;comorbidity;contextual factors;Continuous Positive Airway Pressure;Dangerousness;Data;design;Development;Devices;Diagnosis;Distress;Drowsiness;Economics;Education;effective therapy;effectiveness testing;ethnic minority population;EuroQOL;experience;Goals;Guidelines;Health;health care delivery;health care service utilization;health related quality of life;Healthcare;high risk;improved;innovation;Intervention;Knowledge;low socioeconomic status;Measures;Mediating;Mediator;Modification;mortality;Motivation;Newly Diagnosed;Nurse Practitioners;Obstructive Sleep Apnea;older adult;Outcome;Participant;patient oriented;Patient-Focused Outcomes;Patients;personalized approach;Persons;primary outcome;Psyche structure;Race;racial minority population;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Reporting;Research;responders and non-responders;secondary outcome;Self Efficacy;sex;side effect;social;Socioeconomic Status;standard care;Subgroup;Symptoms;telehealth;Testing;theories;therapy adherence;treatment response

PROJECT_TITLE: Motivational Enhancement and Device Support Interventions to Increase Continuous Positive Airway Pressure Therapy Adherence in Adults with Obstructive Sleep Apnea

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: AR

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Physical Activity;Prevention

ORG_CITY: BLACKSBURG

ORG_DEPT: NUTRITION

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE: Exercise promotes skeletal muscle health resulting in protection from disease; however, the cell signaling required for these benefits remains unclear. The skeletal muscle is made up of multiple cell types which need to “talk” to each other to coordinate their activities so that the skeletal muscle can support the increased energy demand of exercise. This proposal seeks to understand the underlying signaling in different types of cells required for the beneficial skeletal muscle responses to exercise.

PI_NAMEs: CRAIGE, SIOBHAN M (contact)

PROGRAM_OFFICER_NAME: EISENSTEIN, JANA S

PROJECT_TERMS: Acute;Adhesions;Affect;Affinity Chromatography;Automobile Driving;Biogenesis;Cell Communication;Cell Physiology;cell type;Cells;Chronic;Collaborations;Complex;cytokine;Data;Development;Diabetes Mellitus;Disease;Endothelial Cells;Endothelium;enzyme activity;Enzymes;Exercise;exercise intervention;Foundations;frailty;Gene Expression;Genus Hippocampus;Goals;Health;Health Benefit;Health Promotion;Immune;improved;insight;intercellular communication;Investigation;Knock-out;Knowledge;Link;LoxP-flanked allele;Mediating;Mediator;Medicine;Metabolic;Metabolic dysfunction;Metabolism;migration;Mitochondria;mitochondrial metabolism;Modeling;Molecular;Mus;Muscle;Muscle Cells;Muscle Fibers;muscle metabolism;Muscle Mitochondria;NADPH Oxidase;Nitric Oxide;novel;Nuclear;overexpression;Pathway interactions;Pericytes;Phenotype;Play;Positioning Attribute;prevent;Process;Production;Proliferating;protein expression;Publishing;Quality Control;Reactive Oxygen Species;release factor;Research;Resolution;Respiration;response;Ribosomes;Role;Running;sarcopenia;Shapes;Signal Pathway;Signal Transduction;Skeletal Muscle;skeletal muscle metabolism;Stress;stressor;Testing;Therapeutic Intervention;Tissues;tool;transcriptomics;Transgenic Mice;Translating;treadmill;treatment strategy;Tube;Vascular Endothelial Cell;Wild Type Mouse;Work

PROJECT_TITLE: Endothelial Reactive Oxygen Species in Exercise Metabolism


NIH_SPENDING_CATS: Aging

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: Low back pain experienced by millions of Americans is linked to degenerative disc disease, a condition that afflicts the spine. The goal of the proposal is to understand the role of HIF-1-responsive molecular circuitry that controls glucose levels and pyruvate/lactate homeostasis to disc degeneration using novel mouse models.

PI_NAMEs: RISBUD, MAKARAND V (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Address;Aerobic;age related;age related changes;age related decline;Aging;Agonist;Alleles;American;animal old age;anti aging;Bioenergetics;Biological Assay;blood glucose regulation;Blood Vessels;Cell Physiology;Cell Proliferation;Cell Separation;Cell Survival;Cells;Cellular Metabolic Process;ChIP-seq;Citric Acid Cycle;Compensation;conditional knockout;Coupled;Data;Development;Disease Progression;Event;Exhibits;experience;experimental study;gain of function;Generations;Genus Hippocampus;Glucose;glucose metabolism;glucose uptake;GLUT-3 protein;Glutamine;Glycolysis;Goals;Health;Homeostasis;Human;Hypoxia;hypoxia inducible factor 1;in vivo;insight;Intervention;Intervertebral disc structure;intervertebral disk degeneration;Investigation;juvenile animal;Knockout Mice;Label;Lactate Dehydrogenase;Link;loss of function;Low Back Pain;Measures;Mediating;Metabolic;Metabolism;Mitochondria;Molecular;mouse model;Mus;novel;nucleus pulposus;old mice;overexpression;Pathway interactions;pharmacologic;Phase II/III Clinical Trial;Phenotype;Pyruvate;Pyruvate Metabolism Pathway;Regulation;Research;Role;Seminal;Severity of illness;SLC2A1 gene;Spinal;Testing;Tissues;Transcriptional Regulation;Transgenic Mice;Vertebral column

PROJECT_TITLE: Role of HIF-1 in intervertebral disc function

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Clinical Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: CLEVELAND

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative Full-thickness rotator cuff tears are present in at least 25% of individuals in their 60s and are a common cause of shoulder pain, weakness and dysfunction. 20-30% of patients who undergo rotator cuff repair experience a retear, the causes and clinical implications of which are poorly understood but that may lead to recurrence of symptoms and require re-operation. This proposal aims to better understand the longer-term implications of both successful and failed rotator cuff repair healing in order to inform the clinical management of patients with rotator tears as well as research into interventions aimed to improve healing, joint health and longer-term outcomes.

PI_NAMEs: DERWIN, KATHLEEN ANNE (contact);RICCHETTI, ERIC T.

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Age;American;Anatomy;Clinical;Clinical Management;clinical predictors;clinically significant;cohort;Collection;Data;Degenerative polyarthritis;Development;Elbow;Evolution;experience;Failure;Frequencies;Functional disorder;Funding;Graph;Head;healing;Health;high risk;improved;Individual;insight;Institution;Interruption;Intervention;Investments;Isometric Exercise;Joints;Knowledge;Literature;Measures;Mediating;Mediator;migration;Modeling;novel;Operative Surgical Procedures;Osteogenesis;Outcome;Pain;Pathologic;Pathology;Patients;Positioning Attribute;prognostic;prospective;Recurrence;repaired;Repeat Surgery;Reporting;Research;research and development;Risk;Roentgen Rays;Role;Rotator Cuff;rotator cuff tear;Severities;Shoulder;Shoulder Pain;success;Surgeon;Symptoms;targeted treatment;therapy development;Thick;Three-Dimensional Imaging;Time;United States National Institutes of Health;Work

PROJECT_TITLE: Effect of RCR healing on degenerative shoulder changes and 5y clinical outcomes

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Aging;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PITTSBURGH

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE It is generally believed that immune responses triggered by transient DNA damage are beneficial while those associated with persistent DNA damage are detrimental. The project aims to investigate a previously unknown crosstalk between DNA damage and immune responses in aging hematopoiesis. If successfully completed, the project would identify a beneficial persistent DNA damage-immune response pathway and its critical role in aging hematopoiesis.

PI_NAMEs: DU, WEI  (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: aged;Aging;aging related;Anemia;Bone Marrow;Cells;Chronic;conditional knockout;Cyclic GMP;cytokine;Cytoplasm;Defect;Disease;Dissection;DNA Crosslinking Agent;DNA Damage;DNA Repair Disorder;ds-DNA;early onset;Exhibits;Family;functional improvement;Gene Activation;Genes;Genetic Transcription;Goals;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;human model;Immune;Immune response;Inflammasome;Inflammation;Inflammatory;insight;Interferons;Interleukin-6;Ionizing radiation;Knockout Mice;Link;Mediating;member;Metalloproteases;Mitomycin C;Modeling;Molecular;mouse model;Mus;Myelogenous;Myeloid Leukemia;Natural Immunity;Natural regeneration;novel;old mice;Pathway interactions;Phenotype;Play;prevent;Prevention;receptor;Regulation;Reporting;Role;senescence;senescence associated secretory phenotype;SPI1 gene;Stimulator of Interferon Genes;Stress;Testing;Tissues;transcription factor;Up-Regulation

PROJECT_TITLE: A beneficial persistent DNA damage-induced immune response in aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Lung;Natural Products;Rare Diseases

PHR: NARRATIVE We propose that metabolites can function as danger signals, promoting lung epithelial cell death and inflammation pathways. We will identify novel metabolite danger signals in vitro and test them in vivo in murine models of acute lung injury. We will also measure metabolite danger signals in human ARDS biospecimens.

PI_NAMEs: EVANKOVICH, JOHN W (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Antibiotics;aspirate;Automobile Driving;Biological;Biological Markers;Candidate Disease Gene;candidate validation;Cattle;Cell Death;Cessation of life;Clinical;clinical care;cohort;Critical Care;Critical Illness;Cyclic AMP;CYP2F2 gene;Cytochrome a;Cytochrome P450;cytotoxic;Data;Development;Diet;drug repurposing;dysbiosis;endotracheal;Enzymes;Epithelial Cells;experimental study;Exposure to;first-in-human;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gases;gut microbes;high throughput screening;Human;immune activation;Immune response;Impairment;In Vitro;in vivo;Indoles;Inflammation;Inflammatory;inhibitor;Innate Immune System;Intestines;Invaded;Investigation;Knockout Mice;Leaky Gut;Length of Stay;Libraries;Link;Lung;lung injury;Measures;Mechanical ventilation;Mediating;Medicine;Metabolic Biotransformation;Metabolism;Metabolite Interaction;Microbe;microbial;Molecular;Morbidity - disease rate;mortality;mortality risk;mouse model;Mus;National Heart, Lung, and Blood Institute;new therapeutic target;novel;Outcome;participant enrollment;pathogen;Pathogenesis;Pathway interactions;Patients;Pattern;Perfusion;Phenotype;phosphodiesterase IV;Physicians;Physiology;Process;programs;Property;protective effect;Public Health;Registries;Research;Respiratory Failure;response;Risk;Risk Factors;RNA interference screen;Role;selective expression;Severities;Signal Transduction;Skatole;Slice;Specificity;standard of care;Survivors;Testing;therapeutically effective;Tissues;Toxic effect;translational impact;Tryptophan;Universities;Ventilator;Work;Xenobiotics

PROJECT_TITLE: Indole Metabolites as Xenobiotic Danger signals in Acute Lung Injury

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Aging;Breastfeeding, Lactation and Breast Milk;Estrogen;Osteoporosis;Women's Health Research

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative  The objective of this R01 application is to define a novel and critical function of ostecytes through perilacunar/canalicular remodeling to regulate the balance between mineral resorption and mechanical integrity of the maternal skeleton during challenging physiological events such as lactation and menopause. By pursuing this objective we expect to provide new insight into personalized clinical management for osteoporosis in postmenopausal women by considering their pregnancy and lactation histories.

PI_NAMEs: LIU, XIAOWEI SHERRY (contact);WANG, LIYUN

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Biochemical;bone;bone cell;bone health;bone loss;Calcium;Calcium Oscillations;Calcium Signaling;Cellular biology;Circulation;Continuous Infusion;dentin matrix protein 1;Deterioration;Dimensions;Environment;Equilibrium;Estrogen decline;Estrogen deficiency;Event;experimental study;Exposure to;Female;fetal;fracture risk;Funding;Future;Growth;Health;Hormonal;Hormonal Change;imaging platform;In Situ;Infant;Infusion procedures;insight;Lactation;Life;Liquid substance;Maps;Measures;mechanical load;Mechanics;mechanotransduction;Mediating;Memory;Menopause;Metabolic;Minerals;Modeling;Molecular Biology;mouse model;Mus;novel;Osteocytes;Osteogenesis;Osteoporosis;Ovariectomy;Parathyroid Hormone Receptor;parathyroid hormone-related protein;personalized management;Physiological;Population;Postmenopause;Pregnancy;prevent;protective effect;Rattus;Recording of previous events;Recovery;Reporting;Reproduction;reproductive;Research Project Grants;response;Role;Saline;sham surgery;Signal Transduction;skeletal;Skeleton;solute;Structure;System;Tamoxifen;Time;Weaning;Weight-Bearing state;Woman;Work

PROJECT_TITLE: Osteocyte peri-lacunar/canalicular remodeling in maternal bone adaptation


NIH_SPENDING_CATS: Genetics;Osteoporosis

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE This project will examine an unexpectedly critical signaling node in osteoblast and osteocyte physiology that controls bone mass and quality as well as phosphate homeostasis. These findings will have implications on skeletal fragility, osteoporosis, and methods to optimize bone health and maybe provide new targets for regulating bone quality in health and disease.

PI_NAMEs: STAINS, JOSEPH P. (contact)

PROJECT_TERMS: Alkaline Phosphatase;Anabolic Agents;Anabolism;Applications Grants;Automobile Driving;beta catenin;bone;bone cell;bone health;bone mass;bone quality;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium;Calmodulin;Compensation;conditional knockout;cortical bone;cranium;Cues;Data;Defect;Disease;Disparate;Exhibits;experimental study;Fracture;Funding;Gene Expression;Genes;Genetic Transcription;Goals;Grant;Health;Homeostasis;Hypophosphatemia;in vivo;Individual;inorganic phosphate;insight;Kinetics;Knock-out;Knockout Mice;Lysosomes;mechanical load;mechanical properties;Methods;Modeling;Molecular;Mus;neutralizing antibody;Nitric Oxide;osteoblast differentiation;Osteoblasts;Osteocytes;Osteogenesis;Osteoid;Osteopenia;Osteoporosis;Pathway interactions;Phenotype;phosphoproteomics;Phosphotransferases;Physiology;Play;postnatal;Predisposition;protein degradation;protein expression;Protein phosphatase;Protein-Serine-Threonine Kinases;Proteins;Proteomics;Regulation;response;Role;Serine;Serum;Severities;Signal Transduction;skeletal;Skeleton;substantia spongiosa;Testing;Time;Tissues;transcriptome sequencing;Work

PROJECT_TITLE: Osteocyte CaMKII as a Critical Regulator of Bone Physiology Anabolism


ORG_CITY: BRONX

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE  The nucleolus is the ribosome factory of the cell. Ribosomes in turn are the cellular machines that synthesize all proteins. The most important component and backbone of ribosomes is its RNAs. Ribosomal RNAs are heavily modified by small RNA-protein complexes to properly exert their func- tions. This process occurs in one of three recognizable subcompartments of the nucleolus, the dense fibrillar component (DFC), which we propose to be formed by the modification activity. One of the two major families of the small RNA-protein complexes are impaired in dyskeratosis congenita.  Patients with the bone marrow failure syndrome dyskeratosis congenita (DC) fail to produce suf- ficient blood cells to carry oxygen and fight infections. Most frequently DC is caused by mutations in proteins that associate with many different small noncoding RNAs that are required for a vast spectrum of cellular functions. Although one of these functions has been shown to be impaired in DC patients, it is not known if and to what extent other functions associated with these RNA–protein complexes are affected. For example, we will investigate if and how these RNA–protein complexes affect the nuclear organelles where they are found, when they are mutated in DC. This proposal aims to answer these questions and to solve the mystery that underlies the nucleolus and DC. The experiments will charac- terize the fine structure of the nucleolus and identify new avenues of treatment for patients with DC and possibly with other bone marrow failure syndromes.

PI_NAMEs: MEIER, U THOMAS (contact)

PROJECT_TERMS: Address;Affect;Auxins;Binding;Biogenesis;Biological Assay;Biology;Blood Cells;bone marrow failure syndrome;C-terminal;Cell Line;Cell Nucleolus;Cell Nucleus;Cell Physiology;Cells;Complex;Core Protein;Data;density;Disease;Dyskeratosis Congenita;Electron Microscopy;experimental study;Family;fighting;Fluorescence;Genetic Transcription;Guide RNA;Hereditary Disease;Impairment;In Vitro;in vivo;Infection;Inherited;Inherited bone marrow failure;Length;Light;light microscopy;Link;Liquid substance;lymphoblast;Maps;Mediating;Membrane;Methylation;Missense Mutation;Modification;Molecular;Molecular Chaperones;Monitor;Mutate;Mutation;NAP57;novel;Nuclear;Nucleotides;Organelles;Oxygen;Patients;Phase;Physical condensation;Polymerase;Positioning Attribute;Process;protein complex;protein protein interaction;Protein Region;Proteins;Pseudouridine;Recombinant Proteins;Recovery;recruit;Ribosomal RNA;Ribosomes;RNA;RNA Polymerase I;Sampling;Site;Small Nucleolar Ribonucleoproteins;Small Nucleolar RNA;Small RNA;Structure;Telomerase;telomere;Testing;Therapeutic Intervention;transcriptome sequencing;Transfection;Untranslated RNA;Vertebral column

PROJECT_TITLE: Ribosomal RNA modification in nucleoli and disease

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Aging;Cardiovascular;Estrogen;Heart Disease;Women's Health Research

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The current treatment of heart failure with preserved ejection fraction (HFpEF) remains focused on symptoms and does not address the underlying structural changes of cardiac remodeling that are key to disease progression. In this study, I will determine the therapeutic potential of Thrombospondin-1 (TSP-1) on the primary structural cardiac changes that occur in HFpEF, including the effect of biological sex. This study will not only establish the therapeutic potential for TSP-1 inhibition in HFpEF and introduce a new therapeutic approach by targeting matrix remodeling, it will also determine TSP-1’s biology and pathobiology in a hierarchical manner from cells to animals and lay the foundation to transfer this therapy to patients.

PI_NAMEs: STEPPAN, JOCHEN  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Address;Affect;androgen excess;Androgens;Animals;biological sex;Biology;Cardiac;Cardiac Myocytes;cell behavior;Cells;Clinical;Collagen;coronary fibrosis;crosslink;cytokine;Data;Death Rate;Deposition;Diabetes Mellitus;Disease;Disease Progression;Disproportionately impacts women;EFRAC;Elements;Enzymes;Estradiol;Estrogens;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Female;Fibroblasts;Fibrosis;Foundations;Functional disorder;gain of function;Genes;Goals;Gonadal Steroid Hormones;Grant;Growth Factor;Heart;Heart failure;Hormones;Human;Hyperglycemia;Hypoxia;hypoxia inducible factor 1;in vivo;Incidence;Inflammatory;Knowledge;Link;loss of function;Mechanics;Mediator;Menopause;Messenger RNA;Metabolic dysfunction;Metabolic syndrome;Metalloproteases;Modeling;mRNA Expression;Myocardial;Myofibroblast;novel;novel therapeutic intervention;Obesity;Pathway interactions;Patients;Phenotype;Postmenopause;preservation;prevent;Process;protein expression;Proteins;Rattus;receptor;Regulation;Research;Research Personnel;Rodent Model;Role;sex;Signal Transduction;Stanolone;Surface;Symptoms;systemic toxicity;targeted treatment;Testing;Therapeutic;therapeutic target;Thrombospondin 1;Tissues;Toxic effect;Transforming Growth Factor beta;Ventricular Function;Woman

PROJECT_TITLE: Thrombospondin-1's role in heart failure with preserved ejection fraction (HFpEF)

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Clinical Research;Eczema / Atopic Dermatitis;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Racial and Ethnic Minority Health Research

ORG_DEPT: DERMATOLOGY

PHR: Project Narrative The proposed project is relevant to public health because it seeks biomarkers that differentiate inflammatory skin disease in Asian and Hispanic genetic backgrounds, better directing existing treatments and reducing the expense and morbidity stemming from failed treatments. Thus, this proposal is relevant to the part of NIH's mission that addresses technological innovations and clinically directed research strategies as a basis for improving human health.

PI_NAMEs: CHO, RAYMOND JAIHYUN (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Address;Antibodies;Asian;Atopic Dermatitis;Biological Markers;Biology;candidate marker;Cell Separation;Cells;Chronic;Clinical;Clinical Treatment;cohort;CRISPR/Cas technology;Cutaneous;cytokine;Cytokine Signaling;Data;Data Set;Disease;economic impact;effective therapy;Epidermis;Future;GATA3 gene;Gene Abnormality;Gene Activation;gene network;Genes;Genetic;genetic signature;Genetic Transcription;Genomics;Germ Lines;Goals;Grant;Health;Hispanic;Human;IL4 gene;IL5 gene;Immune;Immunofluorescence Immunologic;Immunology;immunomodulatory therapies;improved;individual patient;Inflammation;Inflammatory;innovation;Interleukin-13;interleukin-13 receptor;Investigation;keratinocyte;Knock-out;Knowledge;Laboratories;Link;Mission;Modeling;Molecular;Molecular Abnormality;molecular marker;Morbidity - disease rate;new therapeutic target;novel;Outcome;overexpression;Pathogenicity;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;Population;PPBP gene;Predisposition;Production;Public Health;Publishing;Reporting;Research;Residual Neoplasm;Residual state;Resistance;Resolution;response;Selection for Treatments;Signal Transduction;single-cell RNA sequencing;Skin;skin disorder;stem;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;TC2 Cell;Techniques;technological innovation;Technology;Testing;Th2 Cells;Therapeutic;therapeutic target;Transcript;transcription factor;transcriptomics;TWIST1 gene;United States National Institutes of Health;virulence gene;Work

PROJECT_TITLE: Investigating single-T cell atopic gene networks in Asian and Hispanic genetic backgrounds

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_DEPT: PHARMACOLOGY

PHR: Narrative Statement We propose continuation of M-CERSI that fosters FDA-oriented research, as well as regulatory science information sharing opportunities. The Center's mission is to foster the development of regulatory science – the science of developing new tools, standards and approaches to assess the safety, efficacy, quality and performance of FDA-regulated products. Activities leverage the close geographic proximity between University of Maryland and FDA's main campus.

PI_NAMEs: BENTLEY, WILLIAM E.;POLLI, JAMES E (contact)

PROGRAM_OFFICER_NAME: SEPULVEDA, KRISTIN

PROJECT_TITLE: University of Maryland Center of Excellence in Regulatory Science and Innovation


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PI_NAMEs: NATHAN, CARL FRANCIS (contact);RHEE, KYU Y

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TITLE: Tri-Institutional TRAC Developmental Core


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases;Regenerative Medicine

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative:  Cardiovascular disease is the number one cause of death globally and there is a critical lack of regenerative therapies to repair the cardiac damage underlying the high morbidity and mortality rates. I propose to study the mechanisms by which Reptin represses the division of cardiac muscle cells (cardiomyocytes). By understanding how cardiac cell division is regulated, we can develop new therapies to promote cardiomyocytes to divide and permanently repair cardiac damage to heal the underlying cause of heart disease.

PI_NAMEs: WRANITZ, FELICIA E (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Adult;ATAC-seq;ATP phosphohydrolase;Birth;Bromodeoxyuridine;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac repair;cardiogenesis;Cardiovascular Diseases;Cause of Death;Cell Cycle;Cell Cycle Arrest;Cell division;Chromatin;chromatin remodeling;Cicatrix;cohort;comparison control;Complex;congenital heart abnormality;Congenital Heart Defects;cyclin A2;Data;Data Set;Death Rate;Development;Dissection;DNA;DNA Damage;DNA Repair;DNA-dependent ATPase;Dominant-Negative Mutation;Down-Regulation;Embryo;Engineering;experimental study;Failure;Family member;Feedback;Fertilization;Gamma-H2AX;Gene Expression;Gene Expression Regulation;Genes;Genetic Models;Genetic Transcription;healing;Heart;heart damage;Heart Diseases;Heart Injuries;Human;Hyperplasia;Infarction;Injury;insight;Learning;Life;loss of function;loss of function mutation;Mediating;Messenger RNA;Modeling;Molecular;Morbidity - disease rate;mutant;Mutation;Myocardial;Myocardial Infarction;Myocardium;Natural regeneration;novel;novel therapeutics;overexpression;Pathway interactions;Phenotype;postnatal;PRC1 Protein;Proliferating;Publishing;regenerative;regenerative therapy;Regulation;Reporting;Repression;Resistance;Role;S-Phase Fraction;Siblings;Signal Transduction;Source;Testing;Therapeutic;TP53 gene;Transcript;Transcription Factor AP-1;transcriptome sequencing;Transgenes;Up-Regulation;Zebrafish

PROJECT_TITLE: Regulation of cardiomyocyte proliferation by the Reptin ATPase


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PHR: Project Narrative  Gastrointestinal (GI) sensation is necessary under physiologic and pathologic conditions, and during inflammation, such as inflammatory bowel disease (IBD), mediates abdominal pain. The dorsal root ganglia (DRG) sensory neurons provide the sensory innervation to the colon and allow for pain responses. Here, I propose to uncover how subtypes of DRG neurons respond to inflammation and understand the mechanisms through which they mediate mechanosensation and inflammation-induced mechanical hypersensitivity, which will be critical for identifying therapeutic targets to treat IBD- associated abdominal pain.

PI_NAMEs: WOLFSON, RACHEL LAURA (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TITLE: Mechanisms of mechanosensation and inflammation-induced hypersensitivityin colon innervating DRG sensory neurons

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Lung;Nanotechnology;Prevention;Vaccine Related

ORG_CITY: IRVINE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE The WHO and US authorities have declared the recent outbreak of SARS-CoV-2, which causes COVID- 19, a public health emergency. In this proposal, we leverage and extend our multi-epitope SAPN-based vaccine approach to COVID-19. We will design, produce, and preclinically test the multi-epitope pan- Coronavirus vaccine candidates (designated as Pan-CoV vaccines), delivered mucosally using our SAPN vaccine delivery platform.

PI_NAMEs: BENMOHAMED, LBACHIR  (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: 2019-nCoV;Acute Respiratory Distress Syndrome;Antibodies;Antigens;authority;B-Lymphocytes;Blood;Body Weight decreased;Brain;brain tissue;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cessation of life;chemokine;China;Chiroptera;Coronavirus;coronavirus disease;Coronavirus Infections;coronavirus vaccine;Country;COVID-19;COVID-19 outbreak;COVID-19 severity;COVID-19 susceptibility;CXCL10 gene;CXCL11 gene;CXCL9 gene;cytokine release syndrome;Data;design;Development;Disease;Disease Outbreaks;Elderly;Epithelium;Epitopes;fighting;Future;Goals;Health;Histopathology;HLA A*0201 antigen;HLA-DR Antigens;Human;human coronavirus;Humanities;Immune response;Immune system;Immunization;immunogenicity;immunopathology;in vitro testing;in vivo evaluation;Individual;Inflammatory;Inflammatory Response;innovation;Intervention;Lead;Legal patent;Lung;Medical;Middle East Respiratory Syndrome;Middle East Respiratory Syndrome Coronavirus;Minority Groups;mouse model;Mucous Membrane;nanoparticle;neurotropic;neutralizing antibody;novel;novel coronavirus;Outcome;pandemic disease;Phase I Clinical Trials;Phenotype;Pneumonia;pre-clinical;Preclinical Testing;Predisposition;Preparation;prevent;promoter;prophylactic;protective efficacy;Proteins;prototype;Province;public health emergency;Route;Safety;SARS coronavirus;SARS-CoV-2 genome;SARS-CoV-2 infection;Seasons;self assembly;Severe Acute Respiratory Syndrome;Specificity;Structure of parenchyma of lung;Symptoms;System;T cell response;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;Tissues;Transgenes;Transgenic Mice;United States;universal coronavirus vaccine;vaccine candidate;vaccine delivery;vaccine evaluation;Vaccines;vector;Virus Diseases

PROJECT_TITLE: Developing a Multi-epitope Pan-Coronavirus Vaccine


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative Cytochrome filaments with closely stacked hemes were just recently discovered by us to be responsible for long- range electron transfer. These novel conductive nanowires have great potential as biomedical materials, yet much is still unknown about their mechanism of action and biophysical properties. This proposal aims to identify novel cytochrome filaments in respiring prokaryotes, elucidating their conduction mechanism by biophysical approaches, and designing self-assembled nanowires for biomedical applications.

PI_NAMEs: WANG, FENGBIN  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TITLE: Understanding and using microbial conductive nanowires


ACTIVITY: ZIA

ADMINISTERING_IC: DE

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Neurosciences;Pain Research

PI_NAMEs: HOON, MARK  (contact)

PROJECT_TERMS: Ablation;Afferent Neurons;Brain;chronic itch;Dedications;Detection;Discrimination;Genes;Genetic;Genetic study;interest;Location;Molecular;Molecular Genetics;Mutant Strains Mice;Neurons;novel;optogenetics;Pain;Pathway interactions;Peripheral;pharmacologic;Process;Pruritus;Sensory;Sensory Ganglia;Signal Pathway;Signal Transduction;somatosensory;Specificity;Spinal Cord;Stimulus;System;Techniques;Tissues;transmission process

PROJECT_TITLE: Molecular Genetic Studies of Somatosensation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Depression;Genetics;Human Fetal Tissue;Mental Health;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PI_NAMEs: LOH, Y. PENG  (contact)

PROJECT_TERMS: 3xTg-AD mouse;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amino Acids;Amyloid beta-Protein;Amyloid beta-Protein Precursor;anti-depressive agents;Autophagocytosis;BCL1 Oncogene;BCL2 gene;Behavior;beta catenin;beta-arrestin;Binding;Biogenesis;Biological Assay;Biological Process;Body Weight;Brain;Brain-Derived Neurotrophic Factor;carboxypeptidase H;Cell Cycle;Cell Death;Cell Survival;Cells;Central Nervous System;Child;Chromogranin A;Clip;Co-Immunoprecipitations;Cognitive deficits;cognitive function;Complex;conditioned fear;Corticotropin;Cre lox recombination system;CREB1 gene;Cyclic AMP-Dependent Protein Kinases;Cytoplasmic Granules;cytotoxicity;Data;dentate gyrus;depressive symptoms;design;Development;Diabetes Mellitus;Disease;Dissociation;Down-Regulation;Ear;early childhood;Embryo;embryonic stem cell;Endocrine;Endocrine system;Endocrinology;Endoplasmic Reticulum;endoplasmic reticulum stress;Endorphins;Energy Metabolism;Enzymes;Exhibits;extracellular;FGF2 gene;forced swim test;Functional disorder;G-Protein-Coupled Receptors;gene therapy;gene-targeted therapy;Genes;glial cell-line derived neurotrophic factor;Glucose;Glutamates;Growth Factor;heart function;Hippocampus;Human;Hydrogen Bonding;Hydrogen Peroxide;hyperphosphorylated tau;Immunohistochemistry;Impaired cognition;Impairment;In Vitro;in vivo;Infertility;Inflammatory;inhibitor;Knock-in Mouse;Knock-out;Knockout Mice;Laboratories;Learning;learning ability;Learning Disabilities;Libraries;LoxP-flanked allele;maternal separation;Medial;Mediating;Membrane;Memory;Memory impairment;Mental Depression;Microglia;Mitochondria;molecular dynamics;morris water maze;mouse model;multicatalytic endopeptidase complex;Mus;mutant;Mutation;N-terminal;Names;Neocortex;Nerve Degeneration;nerve stem cell;Nervous System;Neurites;Neurodegenerative Disorders;neurodevelopment;Neuroendocrine Cell;neurogenesis;Neurologic Deficit;neuron loss;Neuronal Dysfunction;neuronal survival;Neurons;Neuropeptides;Neurophysiology - biologic function;neuroprotection;Neurosphere;neurotoxic;neurotoxicity;neurotrophic factor;Neurotrophic Tyrosine Kinase Receptor Type 2;NF1 gene;novel;novel therapeutic intervention;NTF3 gene;Obesity;object recognition;Organelles;overexpression;Oxidative Stress;Parahippocampal Gyrus;Pathway interactions;peptide hormone;Peptides;Physiological;Play;Prefrontal Cortex;prevent;Pro-Opiomelanocortin;prohormone;Proliferating;Proprotein Convertase 1;Proprotein Convertase 2;protein expression;Protein Isoforms;Proteins;Proto-Oncogene Proteins c-akt;receptor;recruit;Reporting;restraint stress;Role;screening;Secretory Vesicles;Senile Plaques;Serotonin;serotonin receptor;Signal Transduction;Site;small molecule;social;Sodium Chloride;Sorting;spatial memory;stem cell differentiation;stem cells;Stress;stress reduction;Surface;synaptogenesis;Tail;Testing;Theoretical model;Therapeutic Agents;therapy development;Transgenic Mice;Transgenic Organisms;vesicle transport;Viral;Weaning

PROJECT_TITLE: Neuropeptides and Carboxypeptidase E/ Neurotrophic Factor-alpha1 in Neural and Cognitive Functions


PI_NAMEs: STOJILKOVIC, STANKO S. (contact)

PROJECT_TERMS: Action Potentials;Address;Adrenal Glands;Adrenal Mass;Affect;Age;Age Months;beta-Endorphin;Calcium;Calcium Channel;Calcium Signaling;Cell membrane;Cell Physiology;cell type;Cells;Collaborations;Communities;Complex;conditional knockout;Corticosterone;Corticotropin;Coupling;Defect;desensitization;Development;Embryo;Endocrine;Enzyme Inhibition;Enzymes;Event;Exocytosis;experimental study;Female;Female infertility;G-Protein-Coupled Receptors;Gene Expression;Generations;Genes;Genetic Markers;Genetic Transcription;GNRH1 gene;GNRHR gene;Golgi Apparatus;Gonadal structure;Gonadotropin-Releasing Hormone Receptor;Gonadotropins;Heterogeneity;Hormone secretion;Hormones;Hyperplasia;hypothalamic pituitary gonadal axis;Hypothalamic structure;immunoreactivity;In Vitro;in vivo;Infertility;information processing;inorganic phosphate;Inositol;Investigation;Ion Channel;Ion Channel Gating;KISS1 gene;Knock-out;knockout animal;Knockout Mice;Lactation;lactotroph;Ligands;Lipids;Lobe;Maintenance;male;Membrane Potentials;mouse model;Mus;National Institute of Child Health and Human Development;Neonatal;Neuroendocrine Cell;Neurons;Neurosecretory Systems;Oogenesis;Ovulation;P2X-receptor;Pathway interactions;Pattern;PAX7 gene;Periodicals;pharmacologic;Phosphatidylinositols;phosphoinositide-3,4,5-triphosphate;phosphoinositide-3,4-bisphosphate;Phospholipase C;Phosphotransferases;Physiological;PIK3CG gene;PIK4CB gene;Pituitary Gland;Pituitary Hormones;Play;POMC gene;Population;postnatal;postnatal development;postnatal period;Process;Prolactin;PTPRN gene;Puberty;Rattus;receptor;receptor function;Receptor Gene;Recombinants;Reproduction;reproductive axis;reproductive tract;Research;Research Personnel;Residual state;Role;Secretory Cell;SERPINA4 gene;Serum;sex;Signal Transduction;single-cell RNA sequencing;Somatostatin Receptor;somatostatin receptor 3;somatostatin receptor 5;Spermatogenesis;Steroid biosynthesis;Stress;Structure;Structure of nucleus infundibularis hypothalami;System;Tissues;Transgenic Organisms;voltage;voltage gated channel;Work;α-Melanocyte stimulating hormone

PROJECT_TITLE: Intracellular Signaling In Endocrine Cells


NIH_SPENDING_CATS: Genetics;Pediatric

PI_NAMEs: MARAIA, RICHARD J (contact)

PROJECT_TERMS: Adenovirus E1A Proteins;Affect;Anticodon;Antigens;Autoantibodies;Autoantigens;base;Biochemistry;Biogenesis;Biological Models;Cell Nucleus;Cell Proliferation;Cells;Cellular biology;Child;Codon Nucleotides;Cytoplasm;Development;Disease;DNA Polymerase III;Enzymes;Eukaryota;Excision;Exhibits;Genes;Genetic;Genetic Code;Genetic Transcription;Germ-Line Mutation;Goals;Growth;Growth and Development function;Guanosine;Health;Hepatitis C;HIV;Human;Human poliovirus;human tissue;interest;Internal Ribosome Entry Site;Introns;Investigation;Knowledge;Link;Lupus;Mediating;Messenger RNA;Metabolism;Modification;Molecular;Molecular Biology;Multienzyme Complexes;Mus;Natural Immunity;Neonatal lupus erythematosus;Normal Cell;Nuclear Localization Signal;Pathway interactions;Patients;Peptide Hydrolases;Phosphoproteins;Phosphorylation Site;Physiological;Poly(A) Tail;Polymerase;Positioning Attribute;posttranscriptional;Production;protein aminoacid sequence;Protein Biosynthesis;Proteins;Regulation;Research;Ribosomal Proteins;Ribosomal RNA;Ribosomes;RNA;RNA Binding;RNA Folding;RNA metabolism;RNA Polymerase III;RNA-Binding Proteins;Role;sensor;Signal Transduction;Sjogren's Syndrome;Small RNA;structural biology;Study models;System;Systemic Lupus Erythematosus;Techniques;tissue/cell culture;Transcript;transcription termination;Transfer RNA;translation factor;Translational Research;Translations;Untranslated RNA;Viral;Virus;Yeasts

PROJECT_TITLE: Molecular Regulation Of RNA Metabolism


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

PI_NAMEs: BUONANNO, ANDRES  (contact)

PROJECT_TERMS: 3-Dimensional;Acute;Adderall;Adult;Affect;Amino Acid Sequence;AMPA Receptors;Anatomy;Anterior;Area;Attention deficit hyperactivity disorder;autism spectrum disorder;Autocrine Communication;Automobile Driving;Axon;Behavior;Behavioral;Binding;Binding Sites;Brain;Brain region;Calcium;Cell surface;cellular targeting;channel blockers;cingulate cortex;clinical efficacy;clinically relevant;Cocaine;Cognitive deficits;cognitive function;cognitive process;Contralateral;Corpus striatum structure;Cortical Synchronization;Cytoplasmic Tail;Dendrites;Development;Dissociation;Dopamine;dopamine transporter;dopaminergic neuron;drug of abuse;Epilepsy;Equilibrium;ErbB4 gene;Etiology;excitotoxicity;experimental study;extracellular;Failure;Fiber;Glutamates;goal oriented behavior;Goals;hippocampal pyramidal neuron;Image;immunoreactivity;Individual;Interneurons;Ketamine;Knockout Mice;Kv2.1 channel;Label;Light;Location;Medial;Mediating;Memantine;Membrane;Mental disorders;Metalloproteases;Microinjections;Midbrain structure;Modality;Molecular Neurobiology;Mus;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;neocortical;nerve supply;Nervous System Disorder;neuregulin 2;Neuregulins;neuron development;neuronal cell body;Neurons;Norepinephrine;NRG1 gene;NRG2 gene;NRG3 gene;optogenetics;Parvalbumins;Pathway interactions;Pattern;Permeability;Pharmaceutical Preparations;Phosphoric Monoester Hydrolases;Phosphorylation;Photometry;Play;postsynaptic;Potassium Channel;Prefrontal Cortex;Presynaptic Terminals;Process;Protein Dephosphorylation;Proteins;Publications;Pyramidal Cells;receptor;Receptor Activation;receptor function;Receptor Signaling;reconstitution;reconstruction;Reporting;response;Ritalin;Role;Schizophrenia;sensor;Signal Pathway;Signal Transduction;Site;Slice;Substantia nigra structure;Synapses;Testing;Thalamic structure;Therapeutic;Transmembrane Domain;uptake;Ventral Tegmental Area;Virus;Visualization;Work

PROJECT_TITLE: Neuregulin-ErbB and NMDA Receptor Signaling in Neuronal Development and Psychiatric Disorders


NIH_SPENDING_CATS: Genetics

PI_NAMEs: HINNEBUSCH, ALAN G (contact)

PROJECT_TERMS: 5' Untranslated Regions;adenylate;Affect;alpha helix;Amino Acids;Amino Acids Activation;Aminoacylation;Anticodon;Base Pairing;Binding;Binding Proteins;Binding Sites;Biochemistry;Biological Models;Bypass;C-terminal;Catalytic Domain;Cells;Chaetomium;Codon Nucleotides;Collaborations;Complex;deacylation;decapping enzyme;Dependence;Dissociation;EIF-2alpha;Elements;GCN2 protein kinase;Gene Deletion;Genes;Genetic;genetic analysis;genetic regulatory protein;GTP Binding;Guanosine Triphosphate;Histidine-Specific tRNA;Histidine-tRNA Ligase;Hydrolysis;Impairment;In Vitro;in vivo;inhibitor;Initiator Codon;Initiator tRNA;Location;MCT-1 gene;Mediating;Messenger RNA;Modeling;Molecular;Molecular Conformation;mRNA decapping;mRNA Decay;mRNA Translation;mutant;Myelin P2 Protein;National Institute of Diabetes and Digestive and Kidney Diseases;Open Reading Frames;Pathway interactions;Peptide Initiation Factors;permissiveness;Phosphorylation;Phosphotransferases;Play;Poly(A) Tail;Poly(A)-Binding Protein I;Poly(A)-Binding Proteins;polysome profiling;Process;Protein Biosynthesis;Protein Subunits;Proteins;Reaction;reconstitution;recruit;Recycling;Reporter;Reporting;response;ribosome profiling;Ribosomes;RNA;RNA Helicase;Role;Scanning;sensor;Site;Starvation;stem;Stress;stress reduction;Structure;termination factor;Terminator Codon;tigecycline;Transcription Coactivator;Transfer RNA;Transfer RNA Aminoacylation;Translating;Translation Initiation;Translational Regulation;Translational Repression;Translations;United States National Institutes of Health;Variant;Viral;Work;yeast protein;Yeasts

PROJECT_TITLE: Molecular Mechanisms of Translational Control


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Infectious Diseases;Orphan Drug;Pediatric;Rare Diseases

PI_NAMEs: DEVER, THOMAS E (contact)

PROJECT_TERMS: Adenosylmethionine Decarboxylase;ADP ribosylation;Affinity;Amino Acid Motifs;Amino Acids;Anabolism;Animal Model;Animals;Bacterial Toxins;Binding;Biochemical;biological adaptation to stress;Candida albicans;cell growth;cell growth regulation;Cell Line;Cells;Codon Nucleotides;Collaborations;Complex;Country;Defect;Dependence;Diphtheria;Disease;Drops;efficacy testing;EIF-2alpha;eIF-5A;Elements;Elongation Factor;Enzymes;Epilepsy;Eukaryotic Cell;eukaryotic initiation factor-5B;Evolution;Exhibits;Family;fungus;Gene Expression;Genes;Goals;Growth;Growth and Development function;GTP Binding;GTP-Binding Proteins;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Homeobox;Homeobox Genes;Homeostasis;Human;human disease;Hydroxylation;Hypoglycemia;Hypogonadism;Hypopituitarism;hypusine;Impairment;induced pluripotent stem cell;Infection;inhibitor;Initiator Codon;insight;Intellectual functioning disability;interest;knock-down;Link;Mammalian Cell;Mediating;MEHMO syndrome;Messenger RNA;Microcephaly;Modeling;Molecular;Molecular Genetics;mouse model;mRNA Translation;Mus;Muscle Weakness;mutant;Mutation;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;Neuronal Differentiation;novel;Nucleotides;Obesity;Open Reading Frames;Ornithine Decarboxylase;overexpression;paralogous gene;Pathogenicity;Patients;Peptide Initiation Factors;Pharmaceutical Preparations;Phase;Phenotype;Phosphorylation;Pituitary Gland;Polyamine Synthesis Inhibition;Polyamines;polyproline;Positioning Attribute;Post-Translational Protein Processing;prevent;programs;Property;Protein Biosynthesis;Protein Kinase;Proteins;Rare Diseases;Recycling;Regulation;Reporter;Repression;reproductive tract;Research;Research Personnel;Ribosomal Frameshifting;Ribosomes;Role;S-Adenosylmethionine;Sampling;Scanning;sensor;Serine;Site;Stress;Structure;Symptoms;targeted treatment;Terminator Codon;Therapeutic;Therapeutic Intervention;tool;Trans-Activators;transcriptome;Transfer RNA;translation factor;Translation Initiation;Translations;uptake;Virulence;Work;X-linked intellectual disability;Yeast Model System;Yeasts

PROJECT_TITLE: Mechanism and Regulation of Eukaryotic Protein Synthesis


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Rare Diseases

PI_NAMEs: WOODGATE, ROGER  (contact)

PROJECT_TERMS: Academy;Affect;Archaea;Area;Attention;Bacteria;base;Binding;Biochemical;biological adaptation to stress;Biological Assay;Brain Glioblastoma;Brain Neoplasms;Brazil;Candidate Disease Gene;candidate identification;Catalytic Domain;Cell Cycle Arrest;Cell Survival;Cells;chemotherapy;Collaborations;Connecticut;Cryoelectron Microscopy;Data;Development;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Maintenance;DNA polymerase iota;DNA Repair Inhibition;DNA replication fork;DNA-Directed DNA Polymerase;Double Strand Break Repair;Down-Regulation;Effectiveness;emerging antibiotic resistance;Enzymes;Escherichia coli;Eukaryota;Eukaryotic Cell;Exhibits;Family;Flow Cytometry;Gamma-H2AX;Genes;genome integrity;genome sequencing;Genotoxic Stress;Glioblastoma;homologous recombination;Human;in vivo;inhibitor;insight;Knock-out;Link;live cell imaging;Maintenance;Malignant Neoplasms;MGMT gene;model organism;Molecular;Molecular Biology;Mutagenesis;Mutate;Mutation;novel;Nucleotide Excision Repair;Operative Surgical Procedures;Organism;Pathway interactions;Patients;Phosphorylation;Poland;Polishes;Polymerase;Process;Prokaryotic Cells;Proteins;RAD23B gene;Rad30 protein;Radiation therapy;reconstitution;Recovery;repaired;Reporting;Research;Resistance;Resolution;response;restoration;Role;S phase;Science;Scientist;Series;single molecule;Site;standard care;Structure;sugar;Surface;Techniques;temozolomide;treatment comparison;UBA Domain;Ubiquitin;ubiquitin-protein ligase;Universities;Up-Regulation;Visit;whole genome;Work

PROJECT_TITLE: DNA Replication, Repair, and Mutagenesis In Eukaryotic And Prokaryotic Cells


NIH_SPENDING_CATS: Biotechnology;Clinical Research;HIV/AIDS;Osteoporosis;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: CHERNOMORDIK, LEONID V. (contact)

PROJECT_TERMS: Aftercare;Antibodies;Biological;Biological Process;bone;Bone Diseases;bone loss;Bone Marrow;Bone Marrow Stem Cell;Bone remodeling;bone resorbing activity;Bone Resorption;C-terminal;Cell fusion;Cell Nucleus;Cell Proliferation;Cell surface;Cells;Cellularity;Charge;Chimeric Proteins;comparative;Culture Media;Cysteine;Defect;Disabling;Disease;Doxycycline;Eukaryota;Event;Fibrous Dysplasia;Genome;Goals;GTP-Binding Protein alpha Subunits, Gs;Histologic;Human;in vitro Model;Individual;insight;Invaded;Lesion;Life;Ligands;Lipid Bilayers;Lipids;Location;Mediating;Membrane;Modeling;Molecular Chaperones;Molecular Weight;monocyte;Mononuclear;mouse model;Mus;mutant;novel;Nuclear;Osteoblasts;osteoclast progenitor;Osteoclasts;Osteocytes;Osteogenesis;osteogenic;osteoprogenitor cell;oxidation;Oxidation-Reduction;Parents;Pathogenicity;Pathology;Personality;Phase II Clinical Trials;Phosphorylation;Play;Pre-Clinical Model;precursor cell;Proliferating;Property;Protein Dephosphorylation;Proteins;Reaction;Reactive Oxygen Species;receptor;Resistance;RNA;Role;Sexual Reproduction;Signal Transduction;skeletal;skeletal disorder;Sorting;Surface;Tissues;trafficking;treatment strategy;Variant;Virus;Work

PROJECT_TITLE: Protein-mediated membrane remodeling