NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurosciences;Precision Medicine;Substance Misuse

PI_NAMEs: CZACHOWSKI, CRISTINE L (contact)

PROJECT_TERMS: Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol misuse;alcohol preferring rats;alcohol response;alcohol seeking behavior;alcohol use disorder;Alcohols;Amygdaloid structure;Animal Model;Anxiety;anxiety-like behavior;anxious;Avidity;Behavior;Behavior Control;Behavioral;Behavioral inhibition;Behavioral Model;Biological;Brain;Characteristics;Consumption;cortico-limbic circuits;Data;Decision Making;Development;drinking;drinking behavior;drug efficacy;Emotional;endophenotype;Family;Family history of;gain of function;Genetic;Genetic Determinism;Goals;Heritability;high intensity drinking;Human;Impulsivity;incentive salience;Individual;Individual Differences;individualized medicine;Intake;International Agency for Research on Cancer;Lead;Learning;loss of function;Measures;Medial;Mediating;Motivation;Motor;National Institute on Alcohol Abuse and Alcoholism;neural;neural circuit;neural correlate;Neural Pathways;novel;Nucleus Accumbens;optogenetics;Pathology;Pathway interactions;Pattern;Phenotype;Play;Positioning Attribute;Post-Traumatic Stress Disorders;precision medicine;Prefrontal Cortex;Psychological reinforcement;Rattus;Reaction Time;Recording of previous events;reinforcer;response;Rewards;Risk;Risk Behaviors;Risk Factors;Rodent Model;Role;Self Administration;sex;Signal Transduction;Stimulus;Strategic Planning;Structure;Testing;trait;Unconscious State;vigilance;Work

PROJECT_TITLE: Motivated Binge and High-Intensity Drinking in Selected Rat Lines


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative The Hub at Rochester: Educating and Advancing Deaf/hard of hearing graduate Students, (THREADgS) project will prepare deaf and hard of hearing pre-doctoral Scholars, currently underrepresented in the biomedical workforce, with training and support for independent academic careers in the biomedical research enterprise.

PI_NAMEs: MORRELL, CRAIG N (contact);WHITE, PATRICIA M.

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Universities

PROJECT_TITLE: IMSD at the University of Rochester

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: ANN ARBOR

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This program focuses on developing new synthetic methods for the construction and late-stage diversification of biologically relevant molecules. Specifically, it leverages the PI's expertise in synthetic methods development, physical organic chemistry/mechanistic analysis, and organometallic chemistry to address important challenges in the areas of transition metal-catalyzed C–H functionalization and cross-coupling reactions.

PI_NAMEs: SANFORD, MELANIE S. (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Address;Area;base;Carbon;Carboxylic Acids;catalyst;chemical reaction;Chemicals;Complex;Coupling;Data;design;Development;drug candidate;Fluorine;Foundations;functional group;Goals;Hydrogen Bonding;interest;invention;Metals;method development;Methods;Modernization;next generation;novel strategies;Organic Chemistry;Organic Synthesis;Organometallic Chemistry;Pharmaceutical Chemistry;programs;Reaction;Site;Structure;Transition Elements;Work

PROJECT_TITLE: Metal-Catalyzed Reactions for Organic Synthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Digital Twin Neighborhoods for Research on Place-Based Health Inequalities in Mid-Life Increasingly, it is recognized that high-value therapies, screening tools and preventive services have created or increased inequalities experienced by persons from racial and ethnic minority backgrounds, those of low socioeconomic position (SEP) and other vulnerable groups. This project aims to chart a new course for understanding place-based population health strategies, empowering community members and organizations, local health systems and population health and political leaders to use evidence from place-based research to inform, prioritize, evaluate and implement health-promoting strategies that close health disparities. The cornerstone innovation of our work is the development of Digital Twin Neighborhoods which will dramatically expand access to data and algorithms for understanding placed-based health and social inequalities.

PI_NAMEs: DALTON, JARROD  (contact);PERZYNSKI, ADAM THOMAS

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Address;Adult;Age;Algorithms;Alzheimer's Disease;Anti-Hypertensive Agents;Automobile Driving;bench to bedside;Biological;Biometry;Blood Pressure;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;career;Chronic Disease;Clinic;Clinical;clinical risk;Cloud Computing;cohort;Communities;community empowerment;community engagement;Community Healthcare;County;COVID-19;Data;Data Analyses;Data Science;Death Certificates;Development;Diabetes Mellitus;digital;digital twin;Disease;Disparity;efficacy evaluation;Electronic Health Record;Environment;Equity;ethnic minority;Event;experience;Funding;Geography;Health;health data;health disparity;health inequalities;Health Policy;Health Promotion;Health system;Healthcare;Homelessness;Improve Access;improved;Incidence;Individual;Inequality;Infant Care;innovation;Inpatients;Institution;Intervention;Investigation;Life Expectancy;Lipids;Literature;low socioeconomic status;Malignant neoplasm of lung;Measures;Medical;member;Mental Depression;Mental disorders;Mental Health Services;Methods;middle age;Modeling;multiple chronic conditions;Neighborhoods;Ohio;open data;Outcome;Outpatients;Pharmaceutical Preparations;Politics;population based;population health;preference;Preventive service;Primary Care;Privacy;privacy preservation;Procedures;racial minority population;Racial Segregation;Research;Research Design;Research Personnel;response;Risk Factors;Screening procedure;Series;sex;Smoking;social;social disparities;social influence;Socioeconomic Status;Sociology;Translating;United States National Institutes of Health;Vulnerable Populations;Work;Writing


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Alzheimer’s disease and related dementias are leading causes of cognitive disability in the elderly that have a devastating impact on millions of lives in the US, while imposing a major burden on caregivers and on the economy of the whole health care system. The present application seeks to explore the novel hypothesis that tau, a major cause of damage in these diseases, exerts its deleterious effects on cognitive function by limiting the cerebral blood supply and starving the brain of oxygen. The findings deriving from the proposed studies will advance our knowledge of the vascular contributions to Alzheimer’s disease and related dementias and may suggest new therapies for these highly prevalent yet untreatable conditions.

PI_NAMEs: IADECOLA, COSTANTINO  (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Address;Age Years;Age-associated memory impairment;Alteplase;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid beta-Protein;arteriole;awake;base;beta amyloid pathology;Blood capillaries;Blood flow;Blood Vessels;Brain;brain health;Brain imaging;Brain region;Caregiver Burden;cerebral oxygenation;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Chronic;Cognitive deficits;cognitive disability;cognitive function;Conscious;Consensus;Coupled;Coupling;Dementia;Development;Diagnostic;Disease;Educational workshop;Elderly;Energy consumption;Event;Failure;Frontotemporal Dementia;Functional disorder;Functional impairment;Funding;Glucose;Health;Healthcare Systems;Human;Hyperactivity;Hyperemia;imaging approach;Impaired cognition;in vivo;Knowledge;Link;MAPT gene;Mediating;Metabolic;Microcirculation;Modeling;Monitor;Mus;Mutation;N-Methyl-D-Aspartate Receptors;Natural History;neocortical;Nerve Degeneration;neural;neural network;Neurons;neurovascular;neurovascular coupling;Nitric Oxide;Nitric Oxide Synthase;novel;novel therapeutics;Nutrient;Oxygen;Pathogenesis;Pathogenicity;Pathologic;Pathology;Penetration;Persons;Phosphorylation;Population;Production;Protein Isoforms;Regulation;response;Rest;Role;sensor;sex;Signal Transduction;Starvation;Supplementation;tau mutation;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic;tissue oxygenation;Tissues;two photon microscopy;United States National Institutes of Health;Vascular blood supply;vascular contributions;Vasodilator Agents;Virulence Factors;whole health

PROJECT_TITLE: Alzheimer Pathology and Neurovascular Dysfunction

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PI_NAMEs: HOPF, FREDERIC WOODWARD (contact)

PROJECT_TERMS: Affect;Alcohol abuse;Alcohol consumption;alcohol response;alcohol use disorder;Alcohols;Amygdaloid structure;Anatomy;Anterior;Anxiety;Behavior;behavioral phenotyping;behavioral response;binge drinking;Brain;cell type;Cells;Consumption;Cues;density;disorder risk;drinking;drinking behavior;Electrophysiology (science);Emotions;Event;Exhibits;Genetic;Genetic Determinism;Goals;Heavy Drinking;Heritability;Home;Human;improved;in vivo;Injections;Insula of Reil;Intake;Light;Link;Maintenance;Mediating;Mediator;Methods;Modeling;motivated behavior;Motivation;negative affect;neurobiological mechanism;Neurons;novel;Nucleus Accumbens;optogenetics;Oral;Output;Pattern;Phenotype;Physiological;Play;Property;Rattus;Recording of previous events;Rewards;Risk;Rodent;Rodent Model;Role;Sedation procedure;Stimulus;Sucrose;sweet taste perception;synergism;Testing;Time;Virus;Wistar Rats;Work

PROJECT_TITLE: Insula to Limbic circuits differentially mediate BHID expression in alcohol-preferring rodent models


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE COUNTY

ORG_STATE: MD

PHR: 8. Project Narrative The untranslated 5’-leader of the human immunodeficiency virus (HIV) genome directs multiple functions during viral replication, including the selective packaging of two copies of the unspliced genome during virus assembly and the recruitment of cellular factors to HIV-1 mRNAs to promote processing and translation. Understanding the molecular structures and mechanisms responsible for these essential functions will lead not only to a more detailed understanding of how HIV replicates, but also to the development of new approaches for the treatment of AIDS and the engineering of improved gene delivery vectors with greater packaging efficiencies.

PI_NAMEs: SUMMERS, MICHAEL FINLEY (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: 3-Dimensional;Acquired Immunodeficiency Syndrome;Adopted;Anti-viral Agents;Behavior;Binding;Binding Sites;Biochemistry;Biology;Biophysics;Cap Binding Protein Complex;Cell membrane;Cells;Complex;database structure;delivery vehicle;Development;dimer;Dimerization;Dominant-Negative Mutation;drug discovery;Drug Targeting;Electron Microscopy;Elements;Engineered Gene;Engineering;Evolution;Exhibits;experimental study;Funding;gag Gene Products;Gene Delivery;Genetic;Genetic Transcription;Genome;Goals;Guanosine;Guide RNA;HIV;HIV Genome;HIV-1;HIV-2;Hybrids;improved;In Vitro;Knowledge;Lead;Light;Location;Messenger RNA;Modeling;Molecular;Molecular Structure;Monitor;monomer;myristoylation;Nature;novel therapeutic intervention;Nuclear Export;nucleic acid binding protein;Nucleotides;particle;promoter;Promoter Regions;Proteins;recruit;Reporting;Retroviridae;RNA;RNA Binding;RNA Cap-Binding Proteins;RNA Probes;RNA Processing;RNA Splicing;Signal Transduction;Site;small molecule;Structure;Testing;three dimensional structure;trafficking;Transcript;Transcription Initiation;Transcription Initiation Site;Translation Initiation;Translations;Viral Genome;Viral Proteins;Viral Structural Proteins;Virion;Virus Assembly;Virus Replication;Work

PROJECT_TITLE: NMR Studies of Retroviral Nucleic Acid Binding Proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-T(90)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: COLLEGE PARK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative  The natural history of human dermal leishmaniasis caused by Leishmania Viannia species provides unequivocal evidence of long-term persistence of parasites in asymptomatically as well as symptomatically infected individuals. This project aims at studying the role of parasite subpopulations and characterizing the transcriptomes, metabolomes and immunophenotypes of host tissues and cells associated with persistent Leishmania infection. It will provide critical knowledge on the metabolic and immunological microenvironments of human tissues permissive for Leishmania persistence, define the signatures and biomarkers of persistence, and advance ex vivo models of persistent Leishmania infection.

PI_NAMEs: EL-SAYED, NAJIB M (contact);GOMEZ, MARIA ADELAIDA

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: 3-Dimensional;Aftercare;Area;Biological Markers;Blood specimen;Cell Culture System;Cells;chronic infection;Clinical;cohort;conjunctiva;Cutaneous Leishmaniasis;Development;Disease;Drug Exposure;drug isolation;Drug resistance;drug-sensitive;Environment;Genotype;healing;Homeostasis;Human;human tissue;Immune;Immune response;Immune Tolerance;Immunologics;Immunophenotyping;Immunosuppression;in vivo;Individual;Infection;Innate Immune Response;Knowledge;latent infection;Leishmania;Leishmania viannia;Lesion;lonely individuals;Macrophage;Metabolic;metabolome;metabolomics;Modeling;Molecular;Molecular Profiling;monocyte;Mucous Membrane;Natural History;Nose;Oropharyngeal;Outcome;Parasites;Participant;Patients;peripheral blood;permissiveness;Phenotype;Plasmodium;Population;Primary Lesion;Protozoa;Protozoan Infections;Recording of previous events;Recurrence;Recurrent disease;Resolution;response;Role;Signs and Symptoms;Skin;spheroids;Structure of mucous membrane of nose;Symptoms;System;Therapeutic;three dimensional cell culture;Tissues;Toxoplasma;transcriptome;transcriptomics;transmission process;Trauma;Treatment Failure;tumor-immune system interactions;Viannia

PROJECT_TITLE: Host and parasite determinants of Leishmania Viannia persistence in naturally infected human populations


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Microglia are the resident immune cells of the brain and express receptors and ion channels that can lead to intracellular Ca2+ rise. Even though investigations of cultured microglia have suggested that Ca2+ dynamics are important for crucial microglia functions such as cell motility, endocytosis and cytokine secretion, it is not known if, when and how microglia experience Ca2+ responses which are temporally directly related to ongoing behavior. The proposed work will define the molecular mechanism of vigilance-dependent microglia Ca2+ elevations and thereby reveal a potential target for therapeutic modulation of microglia activity in neurodegenerative and neuropsychiatric diseases.

PI_NAMEs: PAUKERT, MARTIN  (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Acute;Affect;Anesthesia procedures;Animals;antagonist;Area;Arousal;Astrocytes;Attention;attenuation;awake;Behavior;Behavioral;blood pressure control;Brain;brain cell;cell motility;Cell Physiology;Cells;Cephalic;Chronic;cognitive performance;conditional knockout;cytokine;Cytoskeleton;Data;density;Deterioration;Development;Endocytosis;Event;experience;experimental study;extracellular;Foundations;Future;Gene Deletion;genetic manipulation;Head;Image;Immune;Immune system;Impaired cognition;Impairment;Individual;Inflammatory;interest;Investigation;Ion Channel;Ion Channel Gating;Ischemia;Kinetics;Length;Link;Locomotion;Macrophage;Mechanics;Membrane;Membrane Proteins;Microglia;Molecular;Monitor;Motor;Mus;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;Neurons;neuropsychiatric disorder;novel;Operative Surgical Procedures;Pathologic;Phagocytes;Phagocytosis;pharmacologic;Pharmacology;Photic Stimulation;Population;Potassium;Procedures;Process;Purinoceptor;rational design;receptor;Regulation;Reporting;Residual state;response;selective expression;sensory input;Signal Transduction;Signaling Molecule;Slice;Source;Speed;Synapses;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Transgenic Mice;Translating;Trauma;treadmill;Trees;two photon microscopy;vigilance;Visual;visual processing;voltage;Work

PROJECT_TITLE: Behavioral state-dependent microglia Ca2+ dynamics

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Substance Misuse

PI_NAMEs: LOGRIP, MARIAN LEE (contact)

PROJECT_TERMS: Abnormal coordination;Acute;Address;Alcohol consumption;alcohol preferring mice;alcohol reinforcement;alcohol response;alcohol reward;alcohol seeking behavior;alcohol use disorder;Alcohols;Amygdaloid structure;Anterior;Automobile Driving;base;Behavior;behavior test;Behavioral;Blood;Brain;Brain region;Breeding;Chemosensitization;Chronic;Communication;conditioned place preference;Consumption;Corpus striatum structure;Darkness;Development;drinking;Electrophysiology (science);Ethanol;excitatory neuron;Female;Generations;Genetic;Genetic Determinism;Genotype;Glutamates;Goals;Heavy Drinking;high intensity drinking;Human;Insula of Reil;Intake;Investigation;Knowledge;Legal;Link;male;Measures;Medial;Modeling;motivated behavior;Motivation;Motor;Mus;neural;neuroadaptation;Neurobiology;Neurons;Output;Pathway interactions;Pattern;Persons;pharmacologic;Phenotype;preference;Prefrontal Cortex;Recording of previous events;Regulation;reinforcer;Research;response;Rewards;Rodent;Role;Saccharin;Self Administration;sex;Sex Differences;Slice;Source;Specificity;Testing;Time;Water;Work

PROJECT_TITLE: Circuitry Underlying Escalation and Frontloading of Alcohol Drinking


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE INST FOR BIOMEDICAL/CLINICAL RES

ORG_STATE: WA

PHR: PROJECT NARRATIVE Statins are the most commonly used cholesterol-lowering medication with proven efficacy in reducing cardiovascular disease; however, statins increase the risk of new-onset type 2 diabetes (T2D). The proposed research seeks to understand mechanisms by which statins contribute to development of T2D, focusing on statin-induced toxicity of pancreatic β cells, which play a critical role in maintaining glycemia. Using cell-based and whole-body models, previously unrecognized defects in cholesterol transport and metabolism will be interrogated in order to identify novel therapeutic targets to mitigate statin-induced β-cell dysfunction/death.

PI_NAMEs: ZRAIKA, SAKENEH  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Ablation;Address;Adult;Beta Cell;Cardiovascular Diseases;Cell Death;Cell membrane;Cell Physiology;Cell Survival;cell type;Cells;Cessation of life;Cholesterol;Cholesterol Homeostasis;Cytochrome P450;Data;Defect;Dependovirus;Development;differential expression;Enzymes;Equilibrium;Exposure to;Functional disorder;gene therapy;Genes;Genetic;Human;Impairment;improved;In Vitro;in vivo;inhibitor;Inner mitochondrial membrane;innovation;Insulin;insulin secretion;islet;Islets of Langerhans;Knowledge;Lead;Literature;Mediating;Mediator;Messenger RNA;Metabolism;MicroRNAs;Mitochondria;mitochondrial dysfunction;Modeling;Mus;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;optogenetics;Organelles;overexpression;Patients;Pharmaceutical Preparations;Play;Process;Protein Overexpression;Proteins;Quality Control;Repression;Research;response;Risk;risk mitigation;Role;steroidogenic acute regulatory protein;Structure of beta Cell of islet;Time;Toxic effect;trend

PROJECT_TITLE: Effects of Cholesterol in Pancreatic Islets

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: LM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Social Determinants of Health

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This project aims to develop a book manuscript that synthesizes findings from three NIH-funded studies and over a decade of empirical research on stakeholder perspectives on approaches to achieving diversity and inclusion in precision medicine research. By examining how stakeholders understand and implement concepts of diversity and inclusion in precision medicine research, this book will provide key empirical insights on the consequences of diversity and inclusion practices for our understandings of health and human variation. It will also help inform how future biomedical research and relationships between researchers and communities might be enhanced to more fully realize the goals of inclusion for all populations.

PI_NAMEs: LEE, SANDRA SOO-JIN (contact);SHIM, JANET K

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Applications Grants;Attitude;Basic Science;Behavioral;Bioethics;Biomedical Research;Biotechnology;Books;Categories;Clinical;Clinical Data;clinical practice;Collection;Communities;Conceptions;Consent;Data;Data Collection;Data Set;Dimensions;Disease;diversity and inclusion;Electronic Health Record;Empirical Research;Ensure;Ethics;ethnic diversity;ethnic minority population;Ethnic Origin;Ethnography;European ancestry;expectation;experience;Focus Groups;Funding;Future;General Population;Genetic;Genetic Research;Genetic Variation;Genome;genomic data;Genomic medicine;Genomics;Goals;Grant;Health;health inequalities;Health Policy;Healthcare Systems;Human;Human Genetics;Individual;insight;Institution;Institutionalization;interest;Interview;Knowledge;Length;Manuscripts;Measures;Mediation;Medical;member;Methods;Minority Groups;Nationalities;Outcome;Participant;Patient Preferences;Patients;Policy Maker;Policy Research;Population;population health;Population Heterogeneity;precision medicine;preference;Principal Investigator;Production;Qualitative Research;Race;racial diversity;racial minority population;recruit;Research;Research Personnel;Sampling;Science;Scientific Inquiry;Series;Shapes;Site;social;social culture;social implication;Societies;sociologist;sociology/anthropology;stakeholder perspectives;Technology;Time;Translating;Translations;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Diversity in Practice: the Quest for Inclusion in Precision Medicine


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Genetics;Human Genome;Neurosciences;Substance Misuse

ORG_CITY: BOSTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE Chronic alcohol consumption may result in methyl-adenosine modification of brain RNAs, thus altering the stability and expression of brain RNAs involved in reward or addiction-related pathways. This proposed research will identify differentially methylated and expressed messenger RNAs (mRNAs) in postmortem brains of AUD subjects, validate AUD-associated brain mRNA methylation and expression changes by mouse modeling, and confirm the effect of AUD-associated brain mRNA methylation changes on mRNA expression and neuronal activity by an innovative epitranscriptome editing approach. The findings will provide insight into a novel epitranscriptomic mechanism of AUD and facilitate the design of a novel AUD therapeutic strategy through altering the methylation status of specific mRNAs.

PI_NAMEs: ZHANG, HUIPING  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: addiction;Adult;Affect;Air;Alcohol consumption;alcohol effect;alcohol exposure;alcohol risk;alcohol use disorder;Alcohols;American;Amygdaloid structure;Animal Model;Autopsy;base;Brain;Brain region;brain tissue;Caucasians;Cell Physiology;Cells;Cerebellum;Chronic;chronic alcohol ingestion;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;demethylation;Dependence;design;Digestion;Disease;disorder risk;DNA Methylation;Engineering;Environmental Risk Factor;Epigenetic Process;epitranscriptome;epitranscriptomics;Ethanol;Female;Gene Expression;Genes;genetic risk factor;Genetic Transcription;Genetic Variation;Goals;Guide RNA;Hippocampus;histone modification;Human;Immune response;Individual;innovation;insight;male;Messenger RNA;Methylation;methylome;methylomics;MicroRNAs;Modeling;Modification;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;Neurons;novel;nuclease;Nucleotides;Nucleus Accumbens;Pathway interactions;Patients;pharmacologic;Pharmacological Treatment;Pilot Projects;posttranscriptional;Prefrontal Cortex;putamen;Regulation;Research;Research Design;Resolution;Rewards;RNA;RNA methylation;RNA Splicing;Role;Sampling;Self Administration;Signal Transduction;Site;Stimulus;Therapeutic;Tissue Sample;transcriptome;transcriptome sequencing;transcriptomics;Translating;Translations;Ventral Tegmental Area;Vulnerable Populations

PROJECT_TITLE: Identifying Brain Epitranscriptomic Changes Associated with Alcohol Use Disorder

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Program Director/Principal Investigator (Lachman, Herbert M., M.D.) Narrative: Public Health Relevance Researchers interested in understanding the genetic basis of intellectual disabilities (ID) and autism spectrum disorder (ASD) have a powerful new research tool; induced pluripotent stem cell (iPSC) technology. These cells have the unique capacity to form essentially every type of cell in the body, including neurons and other brain cells. iPSCs can be generated from white blood cells obtained in a simple blood draw. When iPSCs are developed from individuals with ASD and ID, researchers can turn those cells into patient-specific neurons, a truly monumental scientific achievement. In addition to neurons, iPSCs can also be converted into small (several millimeters in diameter) 3-D structures called “cerebral organoids,” which, remarkably, resemble a first trimester fetal brain in their microscopic appearance and molecular functions. Cerebral organoids are being used as a model system to study the effect of ASD and ID-associated mutations on early brain development. In the current proposal, we are studying a condition called Jansen DeVries Syndrome (JdVS), which is caused by mutations in a gene called PPM1D. Children with JDVS suffer from a variety of physical and neuropsychiatric problems in addition to ID, including severe anxiety, feeding problems, and other gastrointestinal issues. We have developed iPSCs from patients with JdVS and have recreated PPM1D mutations in iPSCs derived from typically developing controls using a gene editing technique called CRISPR-Cas9. These iPSCs will be turned into neurons and analyzed with modern molecular tools to identify molecular differences caused by JdVS mutations in order to find novel therapies that will improve their quality of life.

PI_NAMEs: LACHMAN, HERBERT M (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: Achievement;Address;Alleles;anti-cancer research;Appearance;Architecture;ATAC-seq;Attention;autism spectrum disorder;Autoimmune;Behavior;Biological;Biological Models;Blood;Brain;brain cell;C-terminal;Ca(2+)-Calmodulin Dependent Protein Kinase;cancer subtypes;Catalytic Domain;Cell Line;Cell Physiology;cell type;Cells;Cerebrum;Child;Childhood;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Communities;CRISPR/Cas technology;delta protein;Development;Diameter;differential expression;Disease;DNA Repair Pathway;Doctor of Medicine;Drug Targeting;Eating;Engineering;Exons;experimental study;Family;feeding;fetal;First Pregnancy Trimester;Frameshift Mutation;gain of function;gastrointestinal;gene-editing approach;Genes;Genetic;Germ Lines;Glutamates;Impairment;improved;Individual;individuals with autism spectrum disorder;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;induced pluripotent stem cell technology;Inflammatory;inhibitor;Intellectual functioning disability;interest;Knock-out;Knowledge;Leukocytes;Literature;loss of function;loss of function mutation;Magnesium;Malignant - descriptor;Malignant Neoplasms;Mediating;member;Microscopic;millimeter;Modernization;Molecular;Molecular Analysis;molecular marker;molecular phenotype;multiple omics;mutant;Mutate;Mutation;Neurites;Neurons;neuropsychiatry;Nonsense Mutation;novel;novel therapeutics;null mutation;Obsessive-Compulsive Disorder;Organoids;Outcome;overexpression;Pain Threshold;Pathological anxiety;patient derived induced pluripotent stem cells;Patients;Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus Infections;Pharmaceutical Preparations;pharmacologic;Phenotype;phenotypic biomarker;Phosphoproteins;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Principal Investigator;programs;Protein phosphatase;Protein Serine/Threonine Phosphatase;Protein Truncation;Proteins;Proteomics;public health relevance;Quality of life;Reporting;Research;Research Personnel;Resistance;Resources;RNA;SARS-CoV-2 B.1.617.2;small molecule;Stem Cell Development;stem cell model;Symptoms;Syndrome;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;three dimensional structure;tool;TP53 gene;Transcript;transcriptome sequencing;transcriptomics;Tumor Suppressor Genes;Variant

PROJECT_TITLE: Molecular analysis of glutamatergic neurons derived from iPSCs containing PPM1D truncating mutations found in Jansen de Vries Syndrome


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Axonal Pathology and TBI-Related Neurodegeneration (TReND) To reflect the complex neuropathology emerging after traumatic brain injury (TBI), which includes many of the common pathologies of Alzheimer’s disease and Alzheimer’s disease related dementias (AD/ADRD), we have adopted the conceptual framework, “TBI-related neurodegeneration” (TReND). We propose to examine the evolution of TReND in those with history of single moderate or severe or repetitive mild TBI, which we will compare with both ‘normal’ aging and wider neurodegenerative disease, in particular AD/ADRD. Further, we propose to examine these changes in context of diffuse axonal injury (DAI) and potential sex-based differences in the evolution of TReND and AD/ADRD following injury.

PI_NAMEs: SMITH, DOUGLAS HAMILTON (contact);STEWART, WILLIAM

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: abeta accumulation;Acute;Adopted;Aging;aging related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;Appearance;astrogliosis;Atrophic;Automobile Driving;Award;Axon;axon injury;axonal degeneration;Axonal Transport;Binding;Blood Vessels;chronic traumatic encephalopathy;Clinical Data;Cognitive;Complex;Data;Data Set;Development;Diameter;Diffuse Axonal Injury;Dissociation;Event;Evolution;Explosion;Exposure to;Female;Gliosis;Grant;Injury;interest;Interruption;Investigation;Link;male;Microtubule Stabilization;Microtubule-Associated Proteins;Microtubules;mild traumatic brain injury;modifiable risk;Morphology;Natural History;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;neuropathology;normal aging;Outcome;Pathology;Pattern;Phenotype;Phosphorylation;Process;Production;Recording of previous events;Recovery;repaired;response;Risk;Risk Factors;Severities;sex;Sex Differences;Spectrin;tau Proteins;tau-1;Time;tissue archive;Traumatic Brain Injury;United States National Institutes of Health;white matter

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Recovery Support Services;Rehabilitation;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: WALTHAM

ORG_DEPT: MISCELLANEOUS

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Recovery is a dynamic process of behavior change leading to stable improvements in functioning, purpose and well-being in addition to remission from AUD symptoms and cessation of heavy drinking. The proposed study highlights Black men and women and their recovery pathways, provides means for individual recovery support services outside of the formal organization setting, and seeks to understand the recovery organization and community in which these individuals are seeking to sustain their own AUD recovery. By centering our work on the Black population in Detroit, with a Black-led and Black-serving community recovery organization, we will provide both depth and breadth of knowledge that will enable better supports in the future for AUD recovery among Black men and women.

PI_NAMEs: REIF, SHARON  (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: Address;Age;alcohol availability;alcohol consequences;Alcohol consumption;alcohol services;alcohol use disorder;Alcohols;American;Americas;Asian population;behavior change;Birth;Black American;black men;Black Populations;Black race;black women;burden of illness;Capital;Cellular Phone;Cessation of life;Characteristics;Client;Communities;County;COVID-19;Diagnosis;digital;Disease;Disease remission;DSM-V;effectiveness evaluation;Employment;Environment;Ethnic Origin;Evidence based practice;experience;Female;functional improvement;Future;General Population;Goals;health care availability;health disparity;Health Insurance;Heavy Drinking;Heterogeneity;high risk;Imprisonment;improved;Individual;Inequity;Injury;Intervention;Knowledge;Legal;Life Expectancy;Low income;maladaptive behavior;male;Maps;Measures;Methods;Michigan;Minority Groups;Morbidity - disease rate;National Institute on Alcohol Abuse and Alcoholism;Pathway interactions;Personal Satisfaction;Persons;Pharmaceutical Preparations;Policy Maker;Population;Population Group;Probability;Process;Provider;Qualitative Methods;Quality of life;Race;racial disparity;racial population;racism;Randomized, Controlled Trials;Recording of previous events;Recovery;recovery community organization;recovery services;Reporting;Research Personnel;Self Efficacy;service intervention;Services;social health determinants;Social Problems;socioeconomic disparity;stem;Survival Rate;Symptoms;Telephone;treatment as usual;urban setting;Work

PROJECT_TITLE: Advancing Recovery Pathways and Support Services for Alcohol Use Disorders among Black Men and Women


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The purpose of the proposed project is to improve inference, forecasting and decision making in response to emerging infectious diseases by developing a framework to integrate mechanistic and statistical approaches to epidemic modeling and causal inference. Approaches developed will be validated using simulations and retrospective data and applied prospectively to reduce morbidity and mortality in emerging public health crises. Further, they will be incorporated into publically available tools for use in epidemic response.

PI_NAMEs: EDWARDS, JESSIE ;LESSLER, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: African;Algorithms;Area;case-based;Cholera;Cholera Vaccine;Communicable Diseases;Community Health;cost;COVID-19;COVID-19 pandemic;curve fitting;Data;data dashboard;Data Set;Decision Analysis;Decision Making;Decision Theory;Disease;Disease Outbreaks;disease transmission;Ebola;Emerging Communicable Diseases;Ensure;Epidemic;epidemic response;Evaluation;experience;flexibility;Fogs;Future;Geographic Locations;improved;Incidence;Infectious disease threat;innovation;International;Intervention;Knowledge;Liberia;Life;Link;Location;Machine Learning;Methods;Modeling;Morbidity - disease rate;mortality;multidimensional data;new epidemic;Oral;outbreak response;Policies;programs;prospective;Public Health;Research;Research Personnel;response;Series;Shapes;simulation;sound;Statistical Algorithm;Statistical Methods;Statistical Models;surveillance data;System;theories;Time;tool;Translating;transmission process;Update;user-friendly;War;Work;Yemen

PROJECT_TITLE: Merging machine learning and mechanistic models to improve prediction and inference in emerging epidemics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Biotechnology;Brain Disorders;Dementia;Epilepsy;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Lafora disease (LD) is a catastrophic epilepsy that strikes healthy teenagers and leads to constant ever- worsening seizures until it results in death after 10 years. The collaboration in this proposal brings together scientists at the University of Kentucky and Valerion Therapeutics that have identified a cure for LD in mouse models. Our vision is that one day a physician having diagnosed a child with this horrendous epilepsy would have the medicines and technologies to stop the disease in its tracks so that the child is able to resume development and life a healthy and normal life.

PI_NAMEs: GENTRY, MATTHEW S. (contact)

PROGRAM_OFFICER_NAME: ROOF, REBECCA

PROJECT_TERMS: Adolescence;Affect;Age;alpha-amylase;Alpha-glucosidase;Amylases;Animal Diseases;Antibodies;aspirate;Ataxia;autosome;Binding;Biochemical;Biodistribution;Brain;Cells;Cessation of life;Chemicals;Child;childhood epilepsy;Clinic;clinical translation;Collaborations;Convulsions;Cytoplasm;Data;Dementia;Development;Diagnosis;Disease;disease model;Disease Progression;Dose;drug development;drug discovery;Drug Kinetics;Drug Targeting;Engineering;Enzymes;Epilepsy;Etiology;experimental study;Formulation;Frequencies;Genes;Genetic;Glucan 1,4-alpha-Glucosidase;Glucans;Glycogen;glycogen metabolism;Glycogen Storage Disease;Glycogen storage disease type II;Goals;Grant;Half-Life;Human;immunogenicity;Immunoglobulin Fragments;Impaired cognition;improved;In Situ;In Vitro;in vivo;Incidence;Inclusion Bodies;Infusion procedures;Injections;interest;Intractable Epilepsy;Kentucky;Knockout Mice;Lafora Disease;Left;Legal patent;Life;liquid formulation;Maximum Tolerated Dose;Medicine;Methods;Molecular;mouse model;Mus;Mutation;Myoclonic Epilepsies;Myoclonus;Nerve Degeneration;Neurologic;novel;novel strategies;novel therapeutic intervention;Outcome;Pancreas;Pathologic;Patient-Focused Outcomes;Patients;Penetration;Periodic acid Schiff stain method;Pharmacodynamics;Phase;Phase I/II Clinical Trial;Phase I/II Trial;Phenotype;Phosphoric Monoester Hydrolases;Physicians;Positioning Attribute;pre-clinical research;preclinical safety;preclinical study;Proteins;Pulmonary Inflammation;Rare Diseases;Research;Safety;Scientist;Seizures;Series;side effect;Status Epilepticus;Symptoms;Technology;Teenagers;Therapeutic;therapy development;Tissues;Translating;translational therapeutics;Treatment Efficacy;ubiquitin-protein ligase;Universities;uptake;Vegetative States;Vision;Work

PROJECT_TITLE: Treatment of Lafora disease with an antibody-enzyme fusion

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Neurosciences;Regenerative Medicine;Rehabilitation;Stroke

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Stroke is the leading cause of adult disability in the US, with an annual incidence of approximately 800,000 strokes and a prevalence of over 6.6 million stroke survivors. Brain dysfunction following stroke results in behavioral deficits; however, many stroke survivors exhibit some level of recovery, even in the absence of directed therapy. In this grant, we will examine how inhibitory and excitatory circuits influence functional recovery after stroke.

PI_NAMEs: BAUER, ADAM Q (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Adult;Affect;awake;Axon;barrier to testing;Behavior;Behavioral;Brain;brain circuitry;brain dysfunction;Brain Infarction;Brain region;brain repair;Calcium;calcium indicator;cell type;Cells;connectome;Contralateral;Data;density;design;disability;Distant;efficacy evaluation;Equilibrium;Exhibits;experimental study;Global Change;Grant;improved;in vivo;Incidence;Interneurons;Intervention;Ipsilateral;Ischemia;Knowledge;Left;Maps;Measures;Mediating;Methods;Microscopic;Monitor;Motor;Mus;neural network;Neuroanatomy;neurobehavioral;neuroimaging;neuronal circuitry;Neurons;Nodal;noninvasive brain stimulation;optical imaging;optogenetics;Parvalbumins;Pathway interactions;Pattern;Performance;Play;Population;post stroke;Prevalence;Process;Recovery;Recovery of Function;Recovery Support;redshift;repaired;Rest;restoration;Role;Shapes;Site;somatosensory;Stimulus;Stroke;stroke patient;stroke recovery;stroke survivor;Structure;System;Techniques;Testing;Therapeutic Intervention;Tissues;tool;Transgenic Organisms;Treatment Efficacy;Vertebral column

PROJECT_TITLE: Determining the efficacy of therapeutic interventions after stroke from cell specific functional connectomes


ADMINISTERING_IC: OD

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: SKILLMAN

ORG_NAME: BIO TILLION, LLC

ORG_STATE: NJ

PHR: Narrative Regenerative medicine is a rapidly developing and promising ﬁeld of modern medicine. Cells are removed from a patient, then shipped at ultra-cold temperatures to a pharmaceutical company for modiﬁcation, shipped back and then put back into the patient. We are developing a technology that provides a cold-chain of custody for each sample so that the end user can make an informed decision about the sample's viability.

PI_NAMEs: DAVIDOWITZ, HANANEL  (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Adherence;Affect;Back;cell bank;Cells;Clinical;Cold Chains;cold temperature;Computer software;cost;cryogenics;Cryopreservation;Data;data acquisition;data communication;data exchange;Data Storage and Retrieval;design;design,build,test;Diameter;Dryness;Electronics;Ensure;Event;Freezing;Funding;Goals;Harvest;Individual;Liquid substance;Logistics;Marketing;Measures;Memory;Modern Medicine;Modification;Monitor;Nitrogen;Outcome;Patients;Performance;Pharmacologic Substance;Phase;Play;Procedures;Process;Protocols documentation;Publishing;quality assurance;Reader;Recording of previous events;Records;Regenerative Medicine;Reporting;Research;Role;Sampling;Shipping;Techniques;Technology;Temperature;Testing;Therapeutic;therapy outcome;Time;Transportation;Validation;Vial device;wireless;Work;Writing

PROJECT_TITLE: End to End, Cold Chain Validation Using Sample Attached History Log


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Hematology;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because health care costs associated with care for elderly individuals suffering from age-related stem cell disorders, such as myeloproliferative diseases or myelodysplastic syndromes, are rapidly increasing. Despite emerging experimental evidence that HSC myeloid bias is as a significant contributor to the pathogenesis of these conditions, it cannot be targeted by currently available pharmacological agents. Our discovery of Sema4a as a specific niche-derived regulator of myeloid- biased HSC will open a new avenue in therapeutics directed at preservation of stem cell function with age and prevention of myeloid disease development. These aims closely align with the NIH SHINE initiative (PAS-19- 105) which is supported by NHLBI and NIDDK.

PI_NAMEs: SILBERSTEIN, LEV  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Age;age related;Aging;Alleles;Animals;Binding;Biological;Biological Assay;Blood;Blood Platelets;Bone Marrow;bone preservation;candidate validation;cell injury;Cells;chemotherapy;Chronic;Clinical;clinically relevant;Cytotoxic Chemotherapy;Data;Development;Disease;DNA Damage;Dysmyelopoietic Syndromes;Elderly;Endothelial Cells;Endothelium;Engraftment;Evolution;exhaustion;Exposure to;Functional disorder;functional loss;Future;gene correction;Gene Modified;gene therapy;Genetic;Genetic Models;Goals;Health Care Costs;Hematopoiesis;Hematopoietic;hematopoietic stem cell quiescence;hematopoietic stem cell self-renewal;Hematopoietic Stem Cell subsets;Hematopoietic stem cells;Human;Impairment;improved;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Inhibition of Cell Proliferation;innovation;insight;intravital imaging;intravital microscopy;Label;Long-Term Care for Elderly;LoxP-flanked allele;Malignant - descriptor;Mediating;Mesenchymal;Modeling;Molecular;Molecular Profiling;Motility;mouse model;Mus;Myelogenous;Myeloid Progenitor Cells;Myeloproliferative disease;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;Natural regeneration;novel;osteoprogenitor cell;Pathogenesis;Pathway interactions;pharmacologic;plexin;Pre-Clinical Model;premature;preservation;prevent;Prevention;Prevention strategy;Procedures;Proliferating;Property;protective effect;Proteins;Public Health;receptor;Recombinants;reconstitution;Recording of previous events;regeneration function;regenerative;Regulation;Reporter;Research;Risk;Role;self-renewal;Semaphorins;senescence;Signal Pathway;Signal Transduction;single-cell RNA sequencing;stem cell exhaustion;stem cell function;stem cell proliferation;Stem cell transplant;stem cells;Stress;success;Testing;Therapeutic;transcriptomics;translational study;Transplantation;United States National Institutes of Health;VWF gene;Xenograft procedure

PROJECT_TITLE: Extrinsic regulation of primitive, myeloid-biased hematopoietic stem cells by Semaphorin 4a

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_DEPT: GENETICS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Project Narrative: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with high rates of recurrence and metastasis. Epidemiological studies have clearly shown that African American (AA) women are more likely to develop advanced TNBC than Caucasian American (CA) women. In this study, we aim to explore how exosomal miRNAs interact with adverse physical and social environmental risk factors to mediate TNBC progression in different racial groups.

PI_NAMEs: XI, YAGUANG ;YU, QINGZHAO  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Acute;Address;Affect;African American;African American population;African American Women;Animal Model;Bioinformatics;Biological;Blood;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;breast cancer progression;Cancer Patient;Cancer Prognosis;caucasian American;Cause of Death;Characteristics;Chronic;clinical translation;cohort;Data;Development;Diagnosis;Disease Progression;Distant Metastasis;Elements;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;epidemiology study;Ethnic Origin;Ethnic Population;exosome;Exposure to;Genes;Goals;health care availability;health disparity;High Prevalence;Human;In Vitro;in vivo Model;Incidence;Individual;Inherited;innovation;insight;Link;Lipids;Louisiana;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Mediation;Messenger RNA;Metastatic breast cancer;Methods;MicroRNAs;Modeling;Molecular Biology;mortality;Neighborhoods;Neoplasm Metastasis;neoplastic cell;novel;Oncogenic;Outcome;outcome prediction;patient derived xenograft model;Patients;Physical environment;Play;Population;predictive modeling;Prognosis;Proteins;Race;racial disparity;racial health disparity;racial population;Recurrence;regression trees;Reporting;risk prediction;Role;Sampling;social;Social Environment;Socioeconomic Status;socioeconomics;statistics;Stromal Cells;Structure;Survival Rate;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-Derived;United States;Visceral metastasis;Woman;Xenograft procedure

PROJECT_TITLE: Interactions between ES-miRNAs and environmental risk factors are responsible for TNBC progression and associated racial health disparities: a novel analysis with multilevel moderation inferences

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Despite the recognized and urgent need for public health interventions that interrupt outdoor malaria transmission, no such proven interventions are available. Transfluthrin-treated hessian fabric strips offer promise, showing more than six months of mosquito bite deterrence in Tanzanian settings. This project seeks to clarify and advance the evidence base on transfluthrin-treated hessian fabric strips through meta-analysis of Tanzanian studies, semi-field and field testing in Thailand and Cambodia, and user acceptability studies in Cambodia to inform future studies and intervention designs.

PI_NAMEs: CHEN, INGRID TING-TING (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Achievement;Affect;Africa;Area;Beds;Bite;Cambodia;Cambodian;Characteristics;Climate;Culicidae;Data;design;Detergents;Disorientation;Entomology;evidence base;Evolution;experience;field study;forest;Formulation;Foundations;Frequencies;Future;Health behavior change;high risk population;High temperature of physical object;Human;Humidity;Insecticides;Interruption;Intervention;Intervention Studies;Latin America;Malaria;malaria transmission;Mentorship;Meta-Analysis;Pharmaceutical Preparations;preference;protective efficacy;public health intervention;Publishing;Rain;Research;Research Design;Research Personnel;Residual state;scale up;Shapes;skills;small molecule;Source;Southeastern Asia;Surface;Tanzania;Temperature;Testing;Textiles;Thailand;Theory of Change;therapy design;therapy development;Time;Training;transmission process;uptake;vector;Volatilization;Water;Weather

PROJECT_TITLE: Spatial repellents to reduce the outdoor transmission of malaria

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Natural Products;Networking and Information Technology R&D (NITRD)

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Lay Abstract Terpenes are a class of biomolecules with great medical and industrial importance. Developing microbes that can produce terpenes will likely make terpenes more widely available for less cost, but the lack of biosensors for evaluating engineering efforts hampers such development. We propose to use artificial intelligence and directed evolution to quickly create biosensors for a wide variety of terpenes, and thereby fundamentally enable ongoing metabolic engineering efforts.

PI_NAMEs: ELLINGTON, ANDREW D (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: 3-Dimensional;Acceleration;Affinity;Algorithms;Alkaloids;Anabolism;Artificial Intelligence;Binding Sites;Bioinformatics;Biosensor;Chemicals;Complex;computational pipelines;Computer Analysis;convolutional neural network;cost;Data;Data Engineering;Databases;deep learning model;design;Development;Directed Molecular Evolution;Docking;Drug Efflux;efflux pump;Engineering;Enzymes;Evolution;Family;functional improvement;General Practitioners;Genome;high throughput screening;Hydrophobicity;improved;Industrialization;Infrastructure;interest;Learning;Libraries;Ligands;Literature;Machine Learning;Medical;metabolic engineering;Methods;Microbe;Mining;Molecular;Molecular Conformation;molecular dynamics;Monoterpenes;neural network;non-Native;novel;Organism;Pathway interactions;Protein Engineering;protein folding;protein function;Proteins;quantum chemistry;rational design;receptor;Relaxation;Reporting;Residual state;Route;sensor;Solubility;Source;Specificity;Structure;synergism;Terpenes;Time;tool;Training;transcription factor;virtual;X-Ray Crystallography

PROJECT_TITLE: Directed evolution of broadly fungible biosensors

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: RALEIGH

ORG_DEPT: BIOLOGY

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: Narrative  Inflammation is an important biological response that protects us from pathogen invasion; however, its aberrant activation causes and promotes a number of age-related diseases. This project seeks to define how aberrant inflammation occurs and causes diseases at a molecular level by investigating one of the central molecules of inflammatory pathways, a protein kinase TAK1. Outcomes could lead to new approaches for inflammatory diseases.

PI_NAMEs: NINOMIYA-TSUJI, JUN  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: age-related disease;Biological;Cell Death;Complex;Cyclic AMP-Dependent Protein Kinases;Disease;experience;Exposure to;fighting;Funding Mechanisms;Genetically Engineered Mouse;Immune signaling;Immunity;Infection;Inflammation;Inflammatory;Inflammatory Response;Invaded;Malignant Neoplasms;MAP Kinase Gene;MAP3K7 gene;Mediating;microorganism;Molecular;mouse model;Natural Immunity;Nerve Degeneration;novel strategies;Outcome;pathogen;Pathway interactions;pharmacologic;prevent;response;Signal Pathway;Signal Transduction;Tissues;Transcriptional Activation

PROJECT_TITLE: TAK1 signaling pathways

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Pregnancy;Prevention;Social Determinants of Health

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE The prevalence of neurodevelopmental delays (NDDs) in children has increased, therefore the identification of modifiable risk factors is of utmost importance. The inconclusive evidence on the associations between prenatal and early childhood environmental factors and NDDs and sensitive windows of exposure has been a barrier for the implementation of air pollutant regulations for pregnant women. Therefore, it is critical to accurately quantify the risks of NDDs from environmental exposures and identify vulnerable subpopulations based on socioeconomic status in a large cohort of pregnant women and their children.

PI_NAMEs: PAPATHEODOROU, STEFANIA  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 8 year old;Adverse effects;adverse pregnancy outcome;Age;Air;Air Pollutants;Air Pollution;Area;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior Disorders;Big Data;Birth;Body mass index;Brain;Caring;Characteristics;Chemicals;Child;Childhood;climate change;Clinical Data;Code;cohort;Complex;Confidence Intervals;cost;Data;Data Sources;Databases;Developmental Coordination Disorders;developmental disease;Diagnosis;early childhood;Economics;Education;Elements;Environment;Environmental Exposure;Environmental Risk Factor;epidemiology study;Etiology;Exposure to;Fetus;fine particles;follow-up;Goals;hazard;Health;Health protection;Heat Waves;Heritability;implementation barriers;Incidence;Income;Individual;Infant;innovation;Intellectual functioning disability;Intervention;Joints;Knowledge;Language Disorders;Learning Disabilities;Location;Marital Status;Mediating;Medicaid;Medical;Mental Health;Metals;Methods;Modeling;modifiable risk;Modification;Neurodevelopmental Disorder;Nitrogen Dioxide;non-genetic;novel;Outcome;Ozone;Pathway interactions;Pediatric cohort;pollutant;Pollution;population based;postnatal;Predictive Value;Predisposition;Pregnancy;Pregnant Women;prenatal;Prevalence;Privatization;Productivity;Public Health;Race;Regulation;Research;Resources;Risk;Risk Factors;Role;Sample Size;Scientific Evaluation;sex;Smoking;social;socioeconomic disadvantage;Socioeconomic Status;Source;spatiotemporal;Speech Disorders;Statistical Methods;System;Temperature;Uncertainty;Work

PROJECT_TITLE: A national study on the effects of air pollution and temperature on children's neurodevelopmental outcomes

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Traumatic experiences shape us in profound and lasting ways, often producing serious mental health complications. The experiments in this proposal seek to uncover how trauma produces alterations in the brain that lead to distinct fear and anxiety responses. By combining a set of state-of-the-art tools that allow for the precise cells likely to support these responses to be persistently monitored, manipulated, and molecularly profiled, this proposal offers an unprecedented opportunity to advance new biological targets for disease intervention.

PI_NAMEs: PENNINGTON, ZACHARY THOMAS (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Acute;Affect;Amygdaloid structure;Animals;Anxiety;anxiety-like behavior;Applications Grants;Auditory;Award;Behavior;behavior test;Behavioral;Behavioral Assay;biobehavior;Biological;biological adaptation to stress;Brain;Calcium;career;career development;Cells;Communication;Darkness;Data;Data Set;Dedications;defined contribution;Development;differential expression;Disease;Event;experience;experimental study;Fluorescence;Fright;Future;Gene Expression;gene network;Genes;Genetic Transcription;Goals;Grant;Health;Hippocampus;Image;in vivo calcium imaging;Individual;individualized medicine;insight;Institution;Intervention;Laboratories;Learning;Life;Light;Measures;medical schools;Memory;Mental Depression;Mental disorders;Mental Health;Mentors;Mentorship;Modeling;Molecular;Molecular Profiling;Monitor;Mood Disorders;Multiple Trauma;Mus;neural;Neurons;neuropsychiatry;novel;Nuclear;optogenetics;Pathologic;Personnel Management;Phenotype;Play;Positioning Attribute;post-trauma;Post-Traumatic Stress Disorders;Procedures;Process;programs;Protein Synthesis Induction;Psyche structure;psychologic;Research;Research Personnel;response;Role;Shapes;Sorting;Stimulus;Stress;stressor;Substance Use Disorder;Synaptic Transmission;Techniques;tenure track;Testing;Time;tool;Training;transcriptome sequencing;transcriptomics;Trauma;Trauma Research;traumatic event;Vulnerable Populations;Work;Writing

PROJECT_TITLE: Disentangling the Consequences of Trauma


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Nanotechnology;Prevention;Women's Health Research

ORG_CITY: HADLEY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: PROJECT NARRATIVE The ultimate goal of the research, a highly integrated platform technology for multiplex, high-accuracy analysis of circulating microRNAs using a self-contained graphene-enabled device, holds great potential to promote point- of-care diagnosis/prognosis and public health in both short and long terms. The short-term outcome is to enhance disease diagnosis efficiency in time, cost, and sample consumption, and improve the prediction of pre-invasive diseases progression in a large population to enable immediate interventions to alleviate detrimental consequences. In the long run, through clinical trials and translational research on human subjects, the technology can be used for rapid and inexpensive nucleic-acid profiling in the development of customized disease treatment strategies to ultimately progress towards ending the disease.

PI_NAMEs: PING, JINGLEI  (contact)

PROGRAM_OFFICER_NAME: MULVANEY, SHAWN PATRICK

PROJECT_TERMS: Affinity;Animal Model;bioelectronics;Biological Assay;Biological Markers;Biopsy;Biopsy Specimen;Blinded;breast cancer progression;Buffers;circulating microRNA;Clinical;clinical care;clinical translation;Clinical Trials;cohort;Complex;Consumption;Core Facility;cost;detection limit;Development;Devices;Diagnosis;Diagnostic;diagnostic technologies;Disease;disease diagnosis;Disease Progression;DNA;DNA Probes;early screening;Electrodes;Electronics;Generations;genomic predictors;Genomics;Goals;graphene;Hospitals;Hour;human subject;Immunoassay;improved;individualized medicine;Intervention;Investigation;liquid biopsy;Malignant Breast Neoplasm;Measurable;Measures;micro-total analysis system;MicroRNAs;Monitor;mouse model;Mus;new therapeutic target;next generation;Noninfiltrating Intraductal Carcinoma;Nucleic Acids;Oligonucleotides;Operative Surgical Procedures;Outcome;outcome prediction;overtreatment;Pathway interactions;Patients;Performance;pH gradient;Plasma;point of care;point-of-care diagnosis;Population;pre-clinical;prevent;Prognosis;prognostic;programs;Progressive Disease;Property;Public Health;Reaction;Recurrence;Research;response;Risk Assessment;Sampling;screening;sensor;Signal Pathway;Signal Transduction;targeted treatment;Technology;technology platform;technology validation;Testing;Therapeutic;Time;Transducers;Transistors;Translating;Translational Research;treatment response;treatment strategy;user-friendly;Validation;Visit;voltage;Xenograft Model

PROJECT_TITLE: Highly Integrated Nucleic-Acid Analysis Using Graphene Bioelectronics

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetics;Microbiome;Neurodegenerative;Neurosciences;Nutrition;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Traumatic brain injury (TBI)-related neurodegeneration (TReND) and chronic neuroinflammation, a proposed mechanism of TReND, contribute to additional morbidity after TBI. This discovery- based proposal will investigate chronic intestinal dysbiosis, specifically the depletion of acetate- producing commensal bacteria, as a novel mechanism of TReND and chronic microglial activation. In addition, identifying functional alterations to the gut microbiome and robust effects of a promising and translatable therapy, acetate, will provide a foundation for innovative clinical trials to monitor the microbiome and replete microbial metabolites as a means to improve neurologic recovery after TBI.

PI_NAMEs: CLARK, ROBERT S B;MOROWITZ, MICHAEL ;PUCCIO, AVA M.;SIMON, DENNIS WILLIAM (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acceleration;Acetates;Acetylation;Address;Adult;Age;Antibiotics;Attenuated;Bacteria;Behavioral;Binding;blood-brain barrier crossing;Brain;brain health;brain metabolism;brain tissue;Characteristics;Chronic;Circulation;Clinical;Clinical Trials;Collaborations;commensal bacteria;controlled cortical impact;Critical Illness;Data;Diet;dietary;Dietary Fiber;differential expression;drinking water;dysbiosis;Energy Metabolism;Enteral;fatty acid supplementation;Feces;Female;Fermentation;FFAR2 gene;Fiber;field study;follow-up;Foundations;functional outcomes;Gene Expression;Genes;Genetic;glial activation;gut microbiome;gut microbiota;gut-brain axis;Health;High Pressure Liquid Chromatography;Histology;Human;immune function;Immunohistochemistry;Impaired cognition;improved;in vivo;Infiltration;Inflammatory;Injury;innovation;Intake;International;Intervention;Intestines;Ipsilateral;Lesion;Linear Models;Macrophage;Magnetic Resonance Imaging;male;Measures;Medicine;Memory;metabolomics;metaproteomics;microbial;microbial community;microbiome;microbiome composition;microbiome research;microbiota;microbiota metabolites;Microglia;Modeling;Monitor;monocyte;Morbidity - disease rate;morris water maze;mouse model;Mus;NADPH Oxidase;Nerve Degeneration;Nervous System Trauma;neuroinflammation;Neurological outcome;neurological recovery;neuron loss;neuronal survival;neuroprotection;neurotoxic;novel;Observational Study;Operative Surgical Procedures;Outcome Assessment;Patients;Performance;Peripheral;pharmacologic;Phenotype;Population;premature;prevent;Production;prospective;protein TDP-43;public health relevance;Randomized;Reproducibility;Research;Resources;restoration;Resuscitation;Role;secondary outcome;Serum;Severities;Sorting;Supplementation;tau Proteins;Technology;Testing;Therapeutic;therapeutic target;Time;Tissues;transcriptome sequencing;translational study;Trauma;Traumatic Brain Injury;Traumatic Brain Injury recovery;Universities;Volatile Fatty Acids

PROJECT_TITLE: Impact of microbiota-derived metabolites on traumatic brain injury-related neurodegeneration


NIH_SPENDING_CATS: Aging;Brain Disorders;Complementary and Integrative Health;Dietary Supplements;Genetics;Microbiome;Neurosciences;Nutrition;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Traumatic brain injury (TBI) afflicts about three million Americans every year. The highest incidence of TBI occurs in adults aged 75 and older who have higher mortality and worse long- term functional outcomes than younger adults. Schwulst lab at Northwestern University has established a well-reproducible and clinically applicable TBI murine model using controlled cortical impact (CCI). Preliminary data indicate that aged mice brains had significant gut dysbiosis correlating with worse outcomes post-TBI. This proposal will further investigate this observation using quantitative and multidimensional flow cytometry, microbiome modulation, short chain fatty acid supplementation and germ-free mice to study the mechanism for the gut dysbiosis and its functional role in the post-TBI aged brain.

PI_NAMEs: DAVIS IV, BOOKER T (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acetates;Address;Adult;Advisory Committees;Age;age related;aged;Aging;aging brain;aging related;American;Anaerobic Bacteria;Anatomy;Animal Model;Animals;Attenuated;attenuation;Award;Bacteria;behavioral phenotyping;Biology;Brain;brain cell;Brain Injuries;Butyrates;Butyrivibrio;C57BL/6 Mouse;career;Cell Separation;Chronic;clinical application;Clinical Trials;cohort;Complex;controlled cortical impact;Data;dietary;Dietary Fatty Acid;Dietary Fiber;Dietary Intervention;Dietary Supplementation;Dimensions;Disease;Elderly;expectation;fatty acid supplementation;fecal microbiota;fecal transplantation;Fermentation;Flow Cytometry;functional outcomes;Gene Expression Profile;Genes;Germ-Free;glial activation;Goals;Grant;gut bacteria;gut dysbiosis;gut microbiome;gut microbiota;gut-brain axis;Histopathology;Immune;Immunology;improved;Incidence;Injury;insight;Intervention;knowledge base;Laboratories;Learning;Lesion;Magnetic Resonance Imaging;meetings;Mentors;metabolomics;microbial;microbiome;microbiome analysis;microbiota;Microglia;minority scientist;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Nerve Degeneration;Neurocognitive;Neurocognitive Deficit;neuroinflammation;next generation;normal aging;novel;old mice;Outcome;Outcome Measure;Pathologic;Phase;Population;Process;Propionates;Publishing;reconstitution;Replacement Therapy;Reporting;Reproducibility;Research;response;RNA;RNA, Ribosomal, 16S;Role;rRNA Genes;Shapes;single-cell RNA sequencing;skill acquisition;skills;Structure;Symptoms;TBI Patients;TBI treatment;Techniques;therapeutic target;Training;Translating;translational potential;Traumatic Brain Injury;Universities;Volatile Fatty Acids;Water;Work;young adult

PROJECT_TITLE: Fecal Microbiota Transfer Attenuates Aged Gut Dysbiosis and Functional Deficits after Traumatic Brain Injury


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;HIV/AIDS;Immunotherapy;Infectious Diseases;Mental Health;Neurosciences

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

PHR: PROJECT NARRATIVE Although antiretroviral therapy has led to significant virologic suppression, HIV infected macrophages persist in the CNS and contribute to neurocognitive impairment in up to a third of HIV-infected persons. The goal of this proposed research is to develop gamma delta CAR-T cell-based products to target and eliminate HIV- infected macrophages in the CNS.

PI_NAMEs: ROUT, NAMITA  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Address;Adoptive Transfer;antiretroviral therapy;Autopsy;Bar Codes;Biodistribution;Brain;brain tissue;cancer immunotherapy;CAR T cell therapy;CD4 Positive T Lymphocytes;Cell model;cell transformation;Cells;Cellular Stress;Central Nervous System;chimeric antigen receptor;chimeric antigen receptor T cells;clinically relevant;cytotoxicity;Data;design;Development;Engineering;Engraftment;feasibility testing;Foundations;Functional disorder;Future;gene-editing approach;Genetic Engineering;Goals;Granzyme;Hematologic Neoplasms;HIV;HIV-associated neurocognitive disorder;Immune;Impaired cognition;improved;In Vitro;in vitro Assay;in vivo;in vivo evaluation;Infection;Inflammation;Innovative Therapy;insight;latent HIV reservoir;Lentivirus Vector;Location;lymph nodes;Macaca;Macaca mulatta;Macrophage;Microglia;migration;Modeling;Modernization;monocyte;Mutation;Myelogenous;Myeloid Cells;Nervous System Trauma;neuroAIDS;Neurocognitive;Neurocognitive Deficit;neuroinflammation;Neurons;novel;novel strategies;Pathogenesis;Patients;Persons;Pharmaceutical Preparations;prevent;Property;purge;Research;Resistance;Retroviral Vector;Rhesus;Risk;Safety;simian human immunodeficiency virus;Site;SIV;Specificity;Stress;T-Lymphocyte;Testing;Therapeutic;Tissues;transmission process;Viral;Virus;Virus Replication;γδ T cells

PROJECT_TITLE: Development of Gamma delta CAR-T cells to target CNS HIV reservoir


NIH_SPENDING_CATS: Fentanyl Misuse and Addiction;Lung;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_NAME: LOVELACE BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: NM

PHR: PROJECT NARRATIVE Overdose fentanyl via rapid intravenous injection causes sudden death, which is the deadliest in opioid overdose deaths, but the relevant pathophysiological mechanisms and effective countermeasures are still unknown. The proposed study will establish the first animal model of fentanyl-induced sudden death and thereby further determine the pathogenesis of the sudden death and a corresponding countermeasure.

PI_NAMEs: XU, FADI  (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Abbreviations;Absence of pain sensation;Accountability;Acute;Adult;afferent nerve;Afferent Neurons;Agonist;airway obstruction;Analgesics;Anesthesia and Analgesia;Anesthesia procedures;Animal Model;antagonist;Apnea;awake;beta-arrestin;Binding;Biochemistry;C Fiber;Capsaicin;Cause of Death;Cell Nucleus;Cells;Central Sleep Apnea;Cessation of life;Chest wall structure;Clinical;Collection;constriction;Coupled;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Dependence;Deposition;Depressed mood;dermorphin;desensitization;Disease;Dose;Electrophysiology (science);Emergency medical service;Female;Fentanyl;fentanyl overdose;Ganglia;Gender;Glutamates;Heroin;Immunohistochemistry;In Vitro;in vivo;Individual;Injections;interdisciplinary approach;Intravenous Bolus;intravenous injection;Larynx;Life;Lung;male;Mediating;Microinjections;Modeling;mu opioid receptors;mu receptors;Muscle;Naloxone;neural;Neurons;novel;Opioid;opioid abuse;opioid mortality;Opioid Receptor;Overdose;overdose death;Pathogenesis;Pathway interactions;Peripheral;Pharmacology;Pharyngeal structure;Pilot Projects;Play;prevent;Rattus;receptor internalization;Reporting;Reproducibility;respiratory;response;Sensory Nerve Endings;side effect;Signal Pathway;Signal Transduction;Spinal Ganglia;stem;Substance P;Sudden Death;TACR1 gene;Testing;Therapeutic;Time;ventilation

PROJECT_TITLE: Mechanism and Countermeasure of Fentanyl-Induced Sudden Death

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative The central aim of our research is the design, synthesis, and biological evaluation of novel antibiotics effective against multidrug-resistant pathogens of most urgent threat, inspired by small-molecule natural products. We seek to develop modular synthetic strategies to access non-natural product derivatives, enabling deep-seated structural changes that could be accomplished by no other means. Recently, studies in our laboratory have highlighted one such molecule, iboxamycin, that demonstrates an unprecedented resistance-breaking mechanism which we will exploit in the future design and synthesis of antibiotics to combat the pressing global health crisis of antibiotic resistance.

PI_NAMEs: MYERS, ANDREW G (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Acinetobacter baumannii;Address;analog;anomer;Anti-Bacterial Agents;antibiotic design;Antibiotic Resistance;Antibiotics;Bacteria;Binding;Biological;Carbohydrates;chemical synthesis;Chemistry;Clindamycin;Clinical;Collaborations;Collection;combat;Compensation;cost effective;Cytochrome P450;Data;design;Development;Dose;drug discovery;efficacy study;emerging antibiotic resistance;Enterobacter;Enterococcus faecium;Erythromycin;ESKAPE pathogens;Evaluation;experience;Feedback;Future;global health;Glycosides;Hand;Human;Hydrogen Bonding;Hydrophobicity;improved;In Vitro;in vivo;Infection;innovation;insight;Kinetics;Klebsiella pneumoniae;Label;Laboratories;Lead;lead candidate;Life;lincosamide;Literature;Liver Microsomes;Macrolides;Marketing;Metabolic;Methylation;Methyltransferase;Modeling;Modern Medicine;Modernization;Modification;Molecular Conformation;mouse model;Multi-Drug Resistance;multi-drug resistant pathogen;Multiple Bacterial Drug Resistance;Natural Products;novel;novel strategies;oxidation;pathogen;pathogenic bacteria;Pathway interactions;Periodicity;Pharmaceutical Chemistry;pre-clinical;Preparation;programs;Pseudomembranous Colitis;Pseudomonas aeruginosa;Reporting;Research;Resistance;resistance gene;Ribosomal RNA;Ribosomes;Risk;Roentgen Rays;Route;scaffold;Series;Site;small molecule;Staphylococcus aureus;Structure;sugar;Sulfides;Sulfoxide;Testing;Thermodynamics;Traditional Medicine;Tritium;weapons

PROJECT_TITLE: Discovery through chemical synthesis of antibiotics effective against modern bacterial pathogens

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cocaine;Genetics;Mental Health;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Cdk5 is a brain expressed serine/threonine kinase known to regulate negative valence states in male rodents, yet very little is known about the role of Cdk5 in female brain or regulation of the Cdk5 gene in either sex. Gene expression changes conferred by molecular alterations to the genome, known as epigenetic modifications, underlie affective states, including reward seeking and fear learning and memory. There is growing evidence that these changes, and the physiological responses to stress, are regulated differently in men and women. This proposal specifically manipulates Cdk5 in order to pinpoint the role of epigenetic regulation of this single gene following different types of stress. The experimental strategy will complement 30 years of existing literature on the role of Cdk5 in male brain.

PI_NAMEs: HELLER, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Abstinence;Acetylation;Affective;anti-depressive agents;Attenuated;Behavior;Behavioral Paradigm;Blood;Brain;Brain region;cell type;Cocaine;cocaine exposure;cocaine reward;cocaine seeking;cocaine self-administration;Cognition;Complement;conditioned fear;Corpus striatum structure;Corticosterone;CREB1 gene;Cyclin-Dependent Kinase 5;Cyclin-Dependent Kinases;Data;Deacetylation;Development;Dopamine;Emotional;Emotions;EP300 gene;Epigenetic Process;epigenetic regulation;excitatory neuron;fear memory;Female;Fright;Gene Activation;Gene Expression;Genes;Genetic Transcription;Genome;genome-wide;HDAC3 gene;Hippocampus;Histone Acetylation;Histone H3;histone modification;Histones;in vivo;Individual;inhibitor;innovation;interest;Knock-out;knowledge integration;Lead;Learning;Literature;Lysine;male;Measures;Memory;memory encoding;memory retrieval;men;Messenger RNA;Modeling;Modification;Molecular;mRNA Expression;Mus;Negative Valence;Neurons;Nucleus Accumbens;Outcome Measure;overexpression;Pharmaceutical Preparations;phosphoproteomics;Phosphorylation;Physiological;Prosencephalon;protein activation;protein expression;Protein Kinase;Protein-Serine-Threonine Kinases;Proteins;Protocols documentation;recruit;Regulation;Reporting;Repression;Research;response;Rewards;Rodent;Role;roscovitine;Serine;sex;sexual dimorphism;Signal Transduction;Stress;Synaptic plasticity;tau Proteins;tau-1;Testing;Tissues;tool;Transcriptional Regulation;Western Blotting;Woman

PROJECT_TITLE: Epigenetic regulation of Cdk5 in cognition and emotion


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Hematology;Machine Learning and Artificial Intelligence;Neurosciences;Patient Safety;Precision Medicine;Prevention

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative CVST has a high morbidity and mortality in young adults despite anticoagulation treatment. Herein, we propose the development of a predictive score for early identification of high-risk patients using novel biomarkers and advanced analytic methods. The score will be potentially used as a stratification tool to evaluate new therapies.

PI_NAMEs: ORTEGA-GUTIERREZ, SANTIAGO  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Activated Partial Thromboplastin Time measurement;Acute;Address;Admission activity;advanced analytics;Adverse effects;Affect;Age;Alternative Therapies;alternative treatment;analytical method;Anticoagulants;Anticoagulation;Antiplatelet Drugs;Biological;Biological Markers;Blood Cell Count;Cerebral Edema;cerebral vein;Child;Classification;Clinical;clinical biomarkers;clinical practice;Clinical/Radiologic;Coagulation Process;cohort;Coma;conventional therapy;cost;cytotoxic;Dependence;Depressed mood;design;Deterioration;Development;disabled;Disease;Early identification;Edema;efficacy evaluation;Epidemiology;Ethnic Origin;Female of child bearing age;follow-up;functional outcomes;Glasgow Coma Scale;Goals;gradient boosting;Headache;Heparin;high risk;high risk population;Hospital complications;Hour;Image;imaging biomarker;Incidence;Infarction;inflammatory marker;Injury;innovation;Intracranial Hemorrhages;Intracranial Sinus Thrombosis;Intravenous;Iowa;Laboratories;Lasso;Left;Life;Logistic Regressions;Lymphocyte;machine learning method;Magnetic Resonance Imaging;Measures;mental state;Metabolic;Methodology;Methods;model building;Modeling;Morbidity - disease rate;mortality;Nature;neuroimaging marker;Neurologic Examination;neutrophil;novel;novel marker;novel therapeutics;Outcome;patient subsets;Patients;Performance;Persons;Phase;Physiological;Population;predictive modeling;Predictive Value;prevent;Process;productivity loss;prognostic;prognostic model;prospective;Randomized, Controlled Trials;Refractory;Regression Analysis;regression trees;Reproducibility;Research;response;Risk;risk stratification;ROC Curve;Sampling;Sampling Studies;Seizures;sex;Specific qualifier value;Specificity;statistical and machine learning;Stratification;Stroke;Symptoms;Techniques;Testing;Therapeutic;Thrombophilia;Thrombus;tool;United States National Institutes of Health;Universities;Validation;validation studies;Venous;Work;X-Ray Computed Tomography;young adult;young woman

PROJECT_TITLE: Novel risk stratification score for patients presenting with acute Cerebral Venous Sinus Thrombosis


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Neurosciences;Stroke

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed study is relevant to public health because stroke is a leading cause of long-term disability and death in the United States and better treatments are needed. Building on our preliminary research showing that blood pressure variability after stroke may be harmful, in this study we will prove this relationship to be true and define critical elements for a future trial dedicated to lowering blood pressure variability.

PI_NAMEs: DE HAVENON, ADAM H. (contact)

PROJECT_TERMS: Acute;Address;Adrenergic beta-Antagonists;Affect;Age;Alteplase;American;Anterior;Anti-Hypertensive Agents;arm;Autonomic nervous system;Blood Pressure;blood pressure elevation;blood pressure reduction;blood pressure variability;Calcium Channel Blockers;Cessation of life;Circulation;Clinical;Cognition;cognitive change;Data;Dedications;disability;disability risk;Elements;endovascular thrombectomy;Enrollment;Ethnic Origin;experience;Fingers;functional outcomes;Future;Goals;Growth;Guidelines;health care settings;Hemorrhage;high risk;Home;Hospitalization;Hospitals;Hour;Impaired cognition;Individual;Infarction;Intervention;Intravenous;Ischemic Stroke;Knowledge;Link;Long term disability;Magnetic Resonance Imaging;Measurement;Measures;Methods;Morbidity - disease rate;mortality;MRI Scans;novel;novel strategies;Outcome;Patients;Pharmaceutical Preparations;pharmacologic;Photoplethysmography;portability;Positioning Attribute;post stroke;post stroke cognitive impairment;prospective;Public Health;Pupil light reflex;Race;radiological imaging;Regimen;Research;sex;Site;standard of care;Stroke;stroke intervention;stroke outcome;stroke patient;Surrogate Markers;Testing;Therapeutic;thrombolysis;transmission process;United States;United States National Institutes of Health

PROJECT_TITLE: Blood Pressure Variability and Ischemic Stroke Outcome (BP-VISO)


NIH_SPENDING_CATS: Breast Cancer;Cancer;Nutrition;Obesity;Women's Health Research

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: NUTRITION

ORG_NAME: PURDUE UNIVERSITY

PHR: PROJECT NARRATIVE The world is facing a growing epidemic of obesity which, in addition to other consequences, increases the risk of death due to breast cancer metastasis. The proposed studies will elucidate key mechanistic details related to the interaction of a low oxygen environment (hypoxia) with the proinflammatory cytokine interleukin 6 that work in tandem to support aberrant lipid metabolism in obesity-driven metastasis. The results of these studies will contribute to making appropriate, targeted recommendations for preventing obesity-related metastasis.

PI_NAMEs: HURSTING, STEPHEN D;TEEGARDEN, DOROTHY  (contact);WENDT, MICHAEL KEITH

PROJECT_TERMS: Address;Biological Assay;breast cancer metastasis;Breast Cancer Patient;breast cancer progression;cancer cell;Carnitine Palmitoyltransferase I;Cell Survival;Cells;Cessation of life;Chronic;cytokine;Cytoprotection;Data;Development;diet-induced obesity;Disease Progression;Energy Supply;Environment;Enzymes;Equilibrium;Exposure to;fatty acid oxidation;Fatty Acids;Fatty-acid synthase;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Hypoxia;IL-6 inhibitor;improved;In Vitro;in vivo;Inflammation;Inflammatory;Interleukin-6;Laboratories;Light;lipid metabolism;Lipids;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Memory;Metabolic;Metastatic breast cancer;Mitochondria;Modeling;Molecular;mortality risk;mouse model;Neoplasm Metastasis;neoplastic cell;novel;Obesity;Obesity Epidemic;obesity prevention;Oxidative Stress;Oxygen;Patient-Focused Outcomes;Patients;pharmacologic;Positioning Attribute;Primary Lesion;Primary Neoplasm;Production;Prognosis;Proteins;Publishing;Pyruvate Carboxylase;Recommendation;Reporter;Research;Risk;Role;Signal Transduction;Site;Stable Isotope Labeling;STAT3 gene;System;Testing;tumor microenvironment;Up-Regulation;Work

PROJECT_TITLE: Impact of hypoxia on lipid metabolism in obesity-driven breast cancer progression

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Prevention;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Older adults are less likely to disclose suicide ideation to others, seek help for it, or engage social contacts into suicide safety planning. This study combines lab-based and mobile health tools to investigate social cognitive abilities and biases that may interfere with motivational systems involved in help seeking, within the networks of at-risk older people. The goal of the study is identify new targets for interventions that increase help seeking behavior for the benefit of late life suicide prevention.

PI_NAMEs: DEPP, COLIN A. (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Affect;Aging;Area;Behavior;Characteristics;Clinical;Code;Cognitive;cognitive ability;cognitive process;Coupled;Data;depressive symptoms;digital mental health;Disclosure;dyadic interaction;Ecological momentary assessment;Elements;Emotions;Ethnic Origin;Evaluation;Face;Feeling suicidal;Gender;Goals;health care settings;Health Professional;help-seeking behavior;Hypersensitivity;ideation;Impaired cognition;improved;Individual;Influentials;Intervention;Language;late life;Link;Loneliness;Longitudinal Studies;Measurement;Measures;Mediating;Mental Health Services;Methods;mHealth;Modeling;Motivation;motivational processes;multimodality;National Institute of Mental Health;Natural Language Processing;Negative Valence;novel;older adult;Older Population;Outcome;Participant;Pathway Analysis;Patient Self-Report;Pattern;personalized intervention;Positive Valence;predictive marker;Prevention approach;Prevention strategy;Primary Health Care;Process;prospective;Recording of previous events;recruit;Research;Research Domain Criteria;Risk;Safety;safety net;Sampling;Series;social;Social Behavior;social cognition;social contact;social engagement;social factors;social inclusion;Social isolation;Social Network;social structure;Specific qualifier value;Speech;Strategic Planning;Structure;Subgroup;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;System;Task Performances;theory of mind;Time;tool;Translating;Work;young adult

PROJECT_TITLE: Social Cognitive Mechanisms Underlying Disclosure and Help Seeking Behavior in Late-Life Suicide


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: FARMINGTON

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Project Narrative: The protein phosphatase calcineurin (CN) is a ubiquitous ser/thr protein phosphatases, but highly enriched in the brain. Despite decades of research, most CN substrates are still unknown. We have assembled a team of researchers that will be able to overcome this impediment and to allow for novel biological insights to be gained.

PI_NAMEs: PETI, WOLFGANG  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: A kinase anchoring protein;Active Sites;Affinity Chromatography;Alzheimer's Disease;Binding;Biochemical;Biological;Biological Process;Brain;Calcineurin;calcineurin phosphatase;Cell Line;cell type;Cells;Cellular biology;Collaborations;Complex;Coupled;Cyclic AMP-Dependent Protein Kinases;Cyclosporine;Data;Development;Disease;Environment;experimental study;FK506;Foundations;Funding;human disease;Immunosuppressive Agents;inhibitor;innovation;insight;Knowledge;Lead;Long-Term Depression;Long-Term Potentiation;MAP3K7 gene;MAP3K7IP1 gene;Mass Spectrum Analysis;Mediating;Memory;Molecular;Molecular Target;Nervous System Disorder;Nervous System Physiology;neuron development;Neurons;neurotransmission;novel;palmitoylation;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Physiology;Population;Post-Translational Protein Processing;PPP3CA gene;Process;Protein Dephosphorylation;Protein phosphatase;Proteins;Proteome;receptor;Recording of previous events;recruit;Regulation;Research;Research Personnel;Resolution;response;Role;Scaffolding Protein;Serine;Shapes;Signal Pathway;Signal Transduction;Stimulus;Stroke;Structure;Substrate Interaction;success;System;Techniques;therapeutic target;Threonine;tool;voltage;Work

PROJECT_TITLE: Serine/Threonine Phosphatases in Neurological Diseases

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Genetics;Neurosciences

PHR: PROJECT NARRATIVE Dynamic and differential RNA expression and processing among neuronal types underlies differences in neuronal development, fate, and the acquisition of sexual dimorphisms. This study will develop the first complete understanding of these dynamics, fundamental knowledge that is critical to understanding how differential gene expression and splicing are regulated to achieve cellular and functional diversity in the nervous system. The proposed research is relevant to public health because these diversities contribute to neuronal function, structure, and disease susceptibility.

PI_NAMEs: HAMMARLUND, MARC  (contact);HOBERT, OLIVER ;KRISHNASWAMY, SMITA ;MILLER, DAVID M

PROJECT_TERMS: Address;Adhesions;Adult;Alternative Splicing;Atlases;Behavior;Biochemical;Brain;Caenorhabditis elegans;Catalogs;Cell Lineage;cell type;Cells;Chromosome Mapping;Communities;Complex;computerized tools;Data;Data Analyses;data mining;Data Set;data tools;Development;Developmental Gene;differential expression;dimorphism;Disease susceptibility;Future;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;gene product;Genes;Genetic;Genetic Transcription;Genome;genome-wide;Goals;Hermaphroditism;Individual;insight;Knowledge;Learning;Logic;male;Maps;mathematical methods;model organism;Molecular;Nervous System;neurogenetics;neuron development;Neuronal Differentiation;Neurons;Neurosciences;novel strategies;Organism;Pathway interactions;Pattern;Polyadenylation;Process;programs;Protein Isoforms;Proteins;Public Health;Regulation;Research;Resolution;Resources;RNA;RNA Processing;RNA Splicing;sex;sexual dimorphism;single-cell RNA sequencing;Spliced Genes;Structure;Synaptic Transmission;System;Technology;Time;Tissue-Specific Gene Expression;tool;Transcript;transcriptome sequencing;Untranslated RNA;web site;web-accessible;Work

PROJECT_TITLE: Discovery and analysis of the C. elegans neuronal gene expression network (CeNGEN)

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The Portland Alcohol Research Center (PARC) will perform in-depth genetic analyses to evaluate the role of a 4-part brain signaling complex known as the tetrapartite synapse (the pre-synaptic neuron, post-synaptic neuron, astroglial processes, and extracellular matrix) in the risk for chronic heavy alcohol use, consequences of use, and individual variation in alcohol consumption despite high genetic risk. Comprehensive research will be performed in male and female mice and monkeys that will evaluate the constituents of this signaling complex, in addition to its relationship with drinking behavior and cognitive performance. Findings will be integrated to provide comprehensive information relevant to disease prediction and treatment.

PI_NAMEs: PHILLIPS, TAMARA J. (contact)

PROGRAM_OFFICER_NAME: GITIK, MIRI

PROJECT_TERMS: Acute;addiction;Address;alcohol availability;alcohol consequences;Alcohol consumption;alcohol effect;Alcohol Phenotype;alcohol research;alcohol response;alcohol use disorder;Alcohols;analytical method;Animal Genetics;Animal Model;Animals;Applied Genetics;Area;Astrocytes;behavioral genomics;behavioral phenotyping;Bioinformatics;Biopsy Specimen;Brain;Breeding;Categories;Cell Surface Extensions;Cells;Chronic;chronic alcohol ingestion;Cilia;Cognitive;cognitive performance;Complex;Corpus striatum structure;Data;data integration;Disease;DNA;drinking behavior;Education and Outreach;Epigenetic Process;Extracellular Matrix;Extracellular Matrix Proteins;Family history of;Female;flexibility;Funding;Future;Gene Targeting;Genes;Genetic;genetic analysis;Genetic Risk;Genetic Structures;genome editing;genomic profiles;Genomics;Glycosaminoglycans;Goals;Heavy Drinking;high risk;Human Resources;Hyaluronic Acid;Impairment;Individual;Individual Differences;individual variation;Information Dissemination;inhibitory neuron;Intake;Intervention;Investigation;K-12 student;Length;Literature;male;Measures;methylome;methylomics;Modality;Modeling;Modification;Monkeys;Mus;neural;neural circuit;neuroadaptation;Neuronal Plasticity;Neurons;Neurosciences;neurotransmission;nonhuman primate;novel;Nucleic Acid Regulatory Sequences;Outcome;Peptide Hydrolases;Phenotype;Population;postsynaptic neurons;preference;presynaptic neurons;Process;Research;Research Personnel;Research Project Grants;Residual state;Resources;reward circuitry;Risk;Rodent;Role;Sampling;Seasons;segregation;Services;sex;Sex Differences;Signal Transduction;Structure;Surface;Synapses;synaptic function;Synaptic plasticity;Talents;Techniques;Technology;Testing;tool;Training and Education;transcriptome;transcriptomic profiling;transcriptomics;Treatment Efficacy;Variant

PROJECT_TITLE: Behavioral Genomics of Alcohol Neuroadaptation