NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Human

PHR: PROJECT NARRATIVE Despite having near-identical genome sequences, all human cell-types have unique DNA methylation profiles that reflect their individual programs of gene regulatory activity. This research will leverage human population genetics to link DNA methylation patterns to traits recorded in the electronic health record and will couple these data with mechanistic studies to uncover the relationship between DNA methylation, the genome sequence and phenotypic outcomes. These studies will reveal how DNA methylation mediates genome function to establish normal and pathological cellular identities.

PI_NAMEs: HODGES, EMILY  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Area;Biological Assay;Biology;Cell Differentiation process;Cell Line;Cell Physiology;cell type;Cells;Chromatin;clinical phenotype;comparative;Competence;Data;demethylation;Disease Outcome;DNA Methylation;DNA methylation profiling;DNA Sequence;DNMT3a;Electronic Health Record;Elements;embryonic stem cell;Epigenetic Process;epigenome editing;Gene Expression;Gene Expression Regulation;Genes;genetic approach;genetic manipulation;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide;Genomic Segment;Genomics;Genotype;Heart;Hepatocyte;HepG2;Human;human population genetics;Immune;Individual;Link;Liver;Macrophage;mammalian genome;Maps;Mediating;Mediator;Methylation;methylation pattern;model organism;Modeling;monocyte;multiple omics;nerve stem cell;Neurons;Normal Cell;Outcome;Pathologic;Pattern;phenome;Phenotype;Population;Prevalence;programs;Quantitative Trait Loci;Recording of previous events;Regulation;Regulatory Element;Reporter;repository;Research;Site;Specific qualifier value;Testing;trait;transcription factor;transcriptome sequencing;Untranslated RNA;Work;XCL1 gene

PROJECT_TITLE: Decoding genome function with DNA methylation and human phenome data

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Caregiving Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Palliative Care;Rural Health;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: The Aging Focus Pilot Core will promote the advancement of science using technology and artificial intelligence to optimize health and care management for older adults living in their homes independently, and those receiving skilled home and community-based services

PI_NAMEs: BOWLES, KATHRYN HELENE (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Aging;aging in place;Area;Artificial Intelligence;Caregivers;Caring;Chronic Disease;clinical research site;clinical translation;Collaborations;collaboratory;commercialization;Communities;community based service;comorbidity;Data;Data Sources;Databases;Decision Making;Disparity;Educational workshop;Eligibility Determination;end of life care;Equity;Ethics;Family Caregiver;federal poverty level;Fostering;Funding;Future;Goals;Health;health care disparity;Health Services Accessibility;Healthcare;healthy aging;Home;Home Care Agencies;Home Care Services;human capital;Improve Access;Income;Industry;innovation;Institute of Medicine (U.S.);Institution;Institutionalization;interest;Link;Long-Term Care for Elderly;Low income;Managed Care;Marketing;Medicaid eligibility;Medicare;Medicare/Medicaid;member;Mentors;Methodology;Minority Groups;National Research Council;New York;novel;Nursing Homes;older adult;Older Population;Outcome;outreach;patient oriented;Patients;peer networks;person centered;Pilot Projects;pilot test;Policies;Population;Professional Organizations;programs;Provider;Quality of life;Reporting;Request for Proposals;Research;Research Personnel;Risk;Rural;Science;Scientist;Series;Services;Site;skills;success;symposium;Technology;technology intervention;Testing;Training;Validation;Work

PROJECT_TITLE: Aging Pilot Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Successful aging in the home can greatly improve quality of life, improve health outcomes, and reduce burden on the healthcare system. The goal of this project is to establish a national collaboratory for the development, evaluation, and implementation of artificial intelligence software and new technologies to facilitate health aging in the home. The Ethics and Policy Core will examine key ethical issues that in designing and disseminating these technologies.

PI_NAMEs: LARGENT, EMILY  (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Adult;Advisory Committees;Aging;algorithmic bias;Alzheimer's Disease;Alzheimer's disease related dementia;American;Artificial Intelligence;artificial intelligence method;authority;Caring;clinical care;Collaborations;collaboratory;commercialization;Communities;Computer software;Data;data privacy;design;Development;Doctor of Philosophy;Ethical Issues;Ethics;ethnic diversity;Evaluation;experience;functional decline;Funding;Goals;Grant;Guidelines;Health;health disparity;Healthcare Systems;healthy aging;Home;Home environment;human old age (65+);Impaired cognition;Impairment;improved;Industry;innovation;innovative technologies;Intervention;investigator training;late life;Light;Monitor;multidisciplinary;new technology;novel;older adult;Older Population;Outcome;Persons;Phase;Pilot Projects;Policies;policy implication;Population;Positioning Attribute;Psyche structure;Quality of life;racial disparity;racial diversity;Research;Resources;Running;rural disparities;Scholarship;Science;social;Social Change;Technology;technology research and development;Time;tool;Training;Translating;Translations;United States;Work

PROJECT_TITLE: Ethics and Policy Core


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The major goal of this proposal is to analyze sequencing data from ~1000 families of non-Hispanic white, Hispanic and African American ancestry to identify variants and genes that confer risk of late-onset Alzheimer’s Disease (LOAD). We will apply existing and novel family-based analytics to identify LOAD susceptibility genes that can be tested as therapeutic targets. These efforts will be in parallel with and complementary to analyses in the unrelated case-control analyses being conducted on Alzheimer’s Disease Sequencing Project (ADSP) discovery, extension replication and follow-up datasets.

PI_NAMEs: LEAL, SUZANNE M;VARDARAJAN, BADRI N (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Admixture;admixture mapping;Affect;African American;Age;Algorithms;Alzheimer's Disease;Amyloid;apolipoprotein E-4;Autopsy;Awareness;Brain;case control;caucasian American;cognitive function;cognitive performance;cohort;complement C2a;Complex;Consensus;Copy Number Polymorphism;Data;Data Set;Dementia;Deposition;design;Disease;drug development;Elderly;endophenotype;exome sequencing;Extended Family;extracellular;Family;Family member;follow-up;Frequencies;gene discovery;Gene Expression;gene network;General Population;Genes;Genetic;Genetic Epistasis;genetic linkage analysis;genetic pedigree;genetic risk factor;Genome;genome sequencing;genome-wide;Gliosis;Goals;Haplotypes;Heritability;Hispanic Americans;Impaired cognition;Inbreeding;Incidence;Individual;Inherited;insertion/deletion mutation;Large-Scale Sequencing;Late Onset Alzheimer Disease;Memory Loss;Methods;Methylation;middle age;Morphologic artifacts;multi-ethnic;National Institute on Aging;Neurofibrillary Tangles;neuron loss;Neuropsychological Tests;Not Hispanic or Latino;novel;Pathologic;Pathway interactions;Penetrance;Pharmaceutical Preparations;Phenotype;Population;Population Control;protective allele;protective factors;Proteins;Puerto Rican;rare variant;Research;Risk;risk variant;Sample Size;segregation;sex;Single Nucleotide Polymorphism;Source;Susceptibility Gene;Testing;therapeutic target;transcriptome sequencing;transcriptomics;Variant;whole genome

PROJECT_TITLE: Gene discovery in multi-ethnic late-onset Alzheimer's disease families

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Kidney Disease;Nutrition;Patient Safety;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE End-stage kidney disease (ESKD) affects over 700,000 Americans, and dialysis requires substantial patient engagement in order to achieve optimal outcomes. The central hypotheses of this proposal are that health- related social needs (i.e. unstable housing and food insecurity) impede patient engagement and lead to worse outcomes, and represent modifiable targets for intervention that can feasibly be implemented with medical care. Public health relevance: understanding the impact of health-related social needs on dialysis may lead to interventions that improve engagement among economically disadvantaged individuals with ESKD.

PI_NAMEs: NOVICK, TESSA  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: acceptability and feasibility;acute care;Address;Affect;American;Applications Grants;Area;barrier to care;Behavioral;career;Caring;Chronic Disease;clinical epidemiology;Clinical Trials;cohort;Communities;community based participatory research;Community Health Aides;cultural competence;Data;design;Development;Dialysis patients;Dialysis procedure;dietary restriction;disease disparity;Economically Deprived Population;electronic medical record system;Emergency department visit;End stage renal failure;Enrollment;Epidemiologic Methods;experience;Food;food insecurity;General Population;Goals;Health;health care disparity;health disparity;Health Services;Hemodialysis;hospitalization rates;housing instability;Impairment;improved;Individual;Information Systems;Internal Medicine;International;Intervention;intervention refinement;Intervention Trial;Interview;Kidney;Kidney Diseases;large datasets;Length of Stay;Link;marginalized population;Medical;medical schools;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;mid-career faculty;Modality;Modeling;mortality;Nature;Nephrology;Outcome;patient engagement;patient oriented;patient oriented research;Patients;Performance;personalized management;Pharmaceutical Preparations;Population;Population Heterogeneity;Predisposition;professor;public health relevance;Qualitative Methods;Qualitative Research;Regimen;Research;Research Methodology;Research Personnel;Resources;Role;Secure;Series;social;social health determinants;Social Work;Social Workers;socioeconomics;Structure;Testing;Texas;therapy design;therapy development;Time;Training;Transportation;United States;Universities;Veterans Health Administration;Work

PROJECT_TITLE: Impact of Health-related Social Needs on Dialysis Outcomes


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Nanotechnology;Neurosciences

ORG_CITY: RIVERSIDE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

ORG_STATE: CA

PHR: A lack of ideal optogenetic tools to investigate the physiology and pathogenesis of neurological diseases/disorders has been an impediment to the development of therapeutic interventions. The proposed research is relevant to public health by developing new technology based on acoustically activatable nanomaterials that enable the wireless modulation of neuronal functions for neuroscience research. The project speaks directly to the mission of the NIH, particularly in developing innovative technology to improve human health and well-being.

PI_NAMEs: NAM, JIN  (contact);YIN, YADONG

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Achievement;Acoustics;Address;aging population;Animal Testing;Animals;base;Biomedical Engineering;Brain;BRAIN initiative;brain tissue;candidate identification;Cardiovascular system;Cations;Cell Line;Cognitive;Colloids;Complex;Computer Models;Data;Dependence;Development;Dimensions;Disease;Dissection;effective therapy;electrical potential;Electrospinning;Encapsulated;Engineering;Exhibits;Fiber;Fluorides;Goals;Growth;Health;Human;Hybrids;Impairment;improved;In Situ;In Vitro;in vitro Model;Injectable;innovative technologies;interest;Ion Channel;Ions;Light;light emission;Longitudinal Studies;magnetic field;Metals;Methods;Mission;Morphology;Motor;nanocomposite;nanofiber;nanomaterials;nanoparticle;nanopolymer;Nanostructures;nerve stem cell;Nervous System;Nervous System Disorder;neural;neural circuit;Neurons;Neurophysiology - biologic function;neuroregulation;Neurosciences Research;new technology;novel;novel therapeutic intervention;optogenetics;particle;Pathogenesis;Pathologic;Penetration;Performance;Personal Satisfaction;Phase;Photons;Physiological;Physiology;Polymers;polyvinylidene fluoride;Prevalence;Prevention;Process;Property;Public Health;rapid growth;Research;Resolution;response;Sensory;Shapes;Signal Transduction;Site;Source;spatiotemporal;Structure;System;Technology;Testing;therapeutic development;Therapeutic Intervention;Tissues;tool;Transducers;transmission process;ultrasound;United States National Institutes of Health;vinyl fluoride;wireless;Yin;zinc sulfide

PROJECT_TITLE: Mechanoluminescent nanomaterials for optogenetic neuromodulation


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Interventions that promote water consumption in place of sugar-sweetened beverages have shown promise for preventing childhood obesity in schoolchildren. Yet to date, no studies have examined whether applying this approach in childcare centers could help to prevent childhood obesity at an even earlier stage of development. We will conduct a cluster-randomized controlled trial to study how a multilevel childcare-based healthy beverage intervention affects young children’s consumption of beverages and obesity.

PI_NAMEs: PATEL, ANISHA INDRAVADAN (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 5 year old;Adult;Affect;Age;aged;behavior change;Beverages;Body mass index;California;Calories;cardiometabolism;care providers;Caregivers;Child;Child Care;Cluster randomized trial;comorbidity;Consumption;Counseling;Development;dietary;early childhood;Early Intervention;Education;efficacy testing;Energy Intake;Environment;expectation;Family;Food;food environment;Future;Goals;Health;Height;Home;Hour;improved;Intake;Intervention;intervention effect;Juice;Latino;Liquid substance;Low income;Magic;Measurement;Measures;Mediating;Mediator;Metabolic;Modeling;Motivation;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Obesity;obesity in children;obesity prevention;Outcome;Overweight;Parents;Persons;Pilot Projects;Policies;post intervention;prevent;Prevention;Prevention strategy;primary outcome;Public Health;Randomized, Controlled Trials;Research;Risk;Schools;Science;secondary outcome;Self Administration;Self Efficacy;social;social cognitive theory;Source;sugar;Surveys;sweetened beverage;Treatment Efficacy;wasting;Water consumption;Weight

PROJECT_TITLE: A Multi-Level Intervention to Promote Healthy Beverage Intake through Childcare

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CHICAGO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative The goal of this work is to understand how cells govern the architecture and assembly dynamics of cortical actin networks that control cell shape, cell polarization, cell division and tissue morphogenesis. To achieve this, we will use a powerful combination of in vitro reconstitution assays and quantitative microscopy.

PI_NAMEs: MUNRO, EDWIN MARSHALL (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actin-Binding Protein;Actins;Actomyosin;Address;anillin;Architecture;Biological Assay;biophysical analysis;Caenorhabditis elegans;cell cortex;Cell division;Cell membrane;cell motility;Cell Shape;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;cofilin;Color;Complex;Coupling;crosslink;Crosslinker;Cytokinesis;Disease;Embryo;Equilibrium;experience;F-Actin;Feedback;Filament;Generations;Genes;Genetic;Goals;Health;In Vitro;in vivo;Length;Mechanics;Mediating;Microfilaments;Microscopy;Molecular;molecular imaging;monomer;Morphogenesis;Motility;Motor;Myosin ATPase;Myosin Type II;network architecture;non-muscle myosin;particle;plastin;polarized cell;polymerization;Polymers;profilin;Property;Proteins;Quantitative Microscopy;reconstitution;Regulation;Resolution;RNA Interference;Shapes;single molecule;System;Tissues;tool;Total Internal Reflection Fluorescent;Work

PROJECT_TITLE: Dynamic control of actin network architecture in early C. elegans embryos

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: East Hanover

ORG_NAME: KESSLER FOUNDATION, INC.

ORG_STATE: NJ

PHR: Project Narrative  Impairment in new learning and memory is a hallmark symptom of Mild Cognitive Impairment (MCI) and negatively impacts several important aspects of everyday life (e.g., instrumental activities of daily living), but treatment options are limited due to the lack of cognitive rehabilitation (CR) protocols supported by Class I research evidence. To address this critical need, the presently proposed multi-site randomized clinical trial (RCT) examines the efficacy of the Kessler Foundation modified Story Memory Technique (KF-mSMT), a 10-session structured CR treatment composed of the application of imagery and context to facilitate learning. Results are expected to substantially improve our ability to treat learning and memory deficits in persons with MCI, which would lead to improved everyday functioning and overall quality of life for persons with MCI, as well as reduced caregiver burden and slowed transition to dementia.

PI_NAMEs: CHIARAVALLOTI, NANCY D. (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Address;Adult;Aftercare;Age;age-related disease;Aging;Behavior;Behavioral;Brain;Caregiver Burden;Cerebrum;Cognition;cognitive performance;cognitive rehabilitation;daily functioning;Data;data collection site;Dementia;design;disability;Disease;Double-Blind Method;Educational process of instructing;effective intervention;efficacious treatment;efficacy evaluation;efficacy testing;Evaluation;follow-up;Foundations;Functional Magnetic Resonance Imaging;Future;Goals;Grant;Health;Imagery;Immobilization;Impaired cognition;Impairment;improved;Individual;innovation;instrumental activity of daily living;Intervention;Journals;Learning;Life;Literature;Maintenance;Manuals;Measures;Medical;member;Memory;Memory impairment;Methodology;Michigan;mild cognitive impairment;neural correlate;Neurologic;Neurophysiology - biologic function;Neuropsychology;novel;Occupational;older adult;Outcome;Outcome Measure;Participant;participant enrollment;Patients;Pattern;Performance;Personal Satisfaction;Persons;Population;Prevalence;prevent;Protocols documentation;Publishing;Quality of life;Questionnaires;randomized placebo-controlled clinical trial;randomized, clinical trials;Recommendation;Rehabilitation therapy;remediation;Research;research and development;Research Design;Risk;Site;Social Functioning;Standardization;standardize measure;Structure;Symptoms;Techniques;Time;Training;Trauma;treatment effect;United States National Institutes of Health;United States National Library of Medicine;Universities;Work

PROJECT_TITLE: Use of the KF Modified Story Memory Technique to Improve New Learning and Memory in Individuals with Mild Cognitive Impairment

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: BOSTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: RESEARCH & RELATED - OTHER PROJECT INFORMATION - PROJECT NARRATIVE This PPG renewal proposes to fundamentally expand our understanding of the selective and functional modulation of the two cannabinoid receptors, CB1 and CB2. The work will be accomplished through an integrated interdisciplinary effort between collaborating laboratories centered around the development and pharmacological characterization of high-quality probes with improved pharmacological profiles. The results can be used to develop improved therapies for pain as well as addictive, inflammatory and fibrotic disorders.

PI_NAMEs: MAKRIYANNIS, ALEXANDROS  (contact)

PROGRAM_OFFICER_NAME: HILLERY, PAUL

PROJECT_TERMS: Active Sites;addiction;Affective;Affinity;Agonist;Alcohol dependence;Analgesics;analog;anandamide;antagonist;Arrestins;Biological Assay;cannabinergic;cannabinoid receptor;Cannabinoids;CNR1 gene;CNR2 gene;Collaborations;Complex;Coupled;Coupling;Cryoelectron Microscopy;Dependence;design;Development;Diabetic Nephropathy;Disease;drug candidate;drug development;Drug Kinetics;endocannabinoid signaling;Endocannabinoids;Funding;Future;Goals;Grant;GTP-Binding Proteins;improved;In Vitro;in vitro testing;in vivo;Inflammatory;insight;Laboratories;Ligands;liquid chromatography mass spectrometry;Liver Fibrosis;Mediating;Methods;Modeling;Molecular;Molecular Conformation;Mus;mutant;Mutation;Nociception;novel;novel therapeutics;open data;Pain;Pain management;painful neuropathy;Pathway interactions;Periodicity;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenotype;positive allosteric modulator;preference;programs;Property;protein structure;Pulmonary Fibrosis;rational design;receptor;Receptor Signaling;recruit;Research;Residual state;Roentgen Rays;side effect;Signal Transduction;Structure;Testing;Therapeutic;therapeutic development;therapeutic target;tool;Work;Yin-Yang

PROJECT_TITLE: Endocannabinoid Active Sites as Therapeutic Targets


NIH_SPENDING_CATS: Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Substance Misuse

PI_NAMEs: NIKAS, SPYROS P (contact)

PROJECT_TERMS: 2-arachidonylglycerol;ABHD6 gene;Acceleration;Active Sites;Address;Adenylate Cyclase;Affinity;Agonist;analog;anandamide;Animals;antagonist;Binding;Biochemistry;Biological Assay;Biological Availability;Brain;Carrier Proteins;Cells;Characteristics;Chemistry;Classification;CNR1 gene;CNR2 gene;Collaborations;cost;Cyclic AMP;Doctor of Philosophy;Drug Kinetics;endocannabinoid deactivating enzyme;Endocannabinoids;Ensure;Enzymes;Evaluation;fatty acid amide hydrolase;G-Protein-Coupled Receptors;Glycerol;Goals;Grant;Human;Hydrolase;In Vitro;in vivo;Individual;Ion Channel;Laboratories;Laboratory Research;Letters;Ligands;Lipase;Liver Microsomes;Measures;Membrane;Metabolic;Modeling;Mus;novel;Pharmacodynamics;pharmacologic;Pharmacology;Plasma;Positioning Attribute;positive allosteric modulator;Preparation;Program Research Project Grants;programs;Property;Rattus;receptor;receptor binding;Research;scale up;screening;Secure;Signal Transduction;Testing;therapeutic target;tool;Transfection;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MDCN-G]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Brain Disorders;Depression;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Mental Health;Mental Illness;Nutrition;Obesity;Rare Diseases;Sleep Research;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: ITHACA

ORG_DEPT: CHEMISTRY

ORG_NAME: CORNELL UNIVERSITY

PHR: Bacterial chemotaxis enables pathogens such as Vibrio cholerae (cholera), Helicobacter pylori (ulcers and gastric cancer), Treponema pallidum (syphilis) and Borrelia burgderfori (lyme disease) to invade tissues and evade the immune system. In contrast, eukaryotic circadian clocks impact nearly every aspect of behavior and their dysfunction contributes to mental illness (sleep disorders, depression, mania, schizophrenia), cancer, and metabolic disease (diabetes and obesity). Defining molecular mechanisms of these two functionally diverse, yet biochemically related, signaling systems will provide the basic understanding to guide new strategies for the treatment of infectious disease and mental disorders.

PI_NAMEs: CRANE, BRIAN R (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Architecture;Behavior;Biochemical;Biological Process;biophysical techniques;Borrelia;cell growth;cell motility;Cells;Cellular Assay;Chemicals;Chemistry;Chemoreceptors;Chemotaxis;Cholera;circadian pacemaker;Circadian Rhythms;Coupling;Cryoelectron Microscopy;Defect;design;Devices;Diabetes Mellitus;Disease;Drosophila melanogaster;Electron Spin Resonance Spectroscopy;Environment;Exhibits;Feedback;Flagella;Flavins;fly;Functional disorder;fungus;Gene Expression;Generations;Genes;Genetic Transcription;Goals;Helicobacter pylori;Human;human pathogen;Immune Evasion;Immune system;In Vitro;in vivo;Infection;infectious disease treatment;Invaded;Investigation;Ions;Light;light entrainment;Lyme Disease;Macromolecular Complexes;Malignant Neoplasms;malignant stomach neoplasm;Manic;Measures;Membrane;Memory;Mental Depression;Mental disorders;Metabolic;Metabolic Diseases;Metabolism;Metals;Methods;Modeling;Molecular;molecular array;Molecular Conformation;molecular dynamics;Motility;Motor;nanomachine;Nature;Neurospora crassa;novel therapeutic intervention;Nucleotides;Obesity;Optics;Order Spirochaetales;Output;Oxidation-Reduction;pathogen;Pathogenicity;Phase;Phosphotransferases;Photochemistry;physical property;Physiologic pulse;programs;Protein Engineering;protein-histidine kinase;Proteins;receptor;reconstitution;Regulation;Repressor Proteins;response;Roentgen Rays;Rotation;Schizophrenia;sensor;Sensory;Signal Transduction;Sleep Disorders;Spectrum Analysis;Structure;Switching Complex;Syphilis;System;Testing;Tissues;Torque;Transcription Coactivator;Treponema pallidum;Ulcer;Vibrio cholerae;X-Ray Crystallography

PROJECT_TITLE: Molecular mechanisms of signaling systems responsive to light, redox and chemical environment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Substance Misuse

PROJECT_TERMS: Active Sites;addiction;Affinity;Agonist;Alcohol dependence;Allosteric Site;Amino Acids;antagonist;Arrestins;Binding;Biochemical;Boronic Acids;cannabinergic;cannabinoid receptor;Cannabinoids;CB1 receptor antagonist;Characteristics;CNR1 gene;CNR2 gene;Complex;Computing Methodologies;Coupled;Cryoelectron Microscopy;Data;Dependence;desensitization;design;Development;Diabetic Nephropathy;Disease;drug candidate;drug development;Endocannabinoids;Exhibits;Feedback;Fluorides;Funding;Goals;GTP-Binding Proteins;improved;In Vitro;in vivo;Indoles;Inflammatory;Isothiocyanates;Kidney;Laboratories;Ligands;liquid chromatography mass spectrometry;Liver;Liver Fibrosis;Lung;Methods;Modeling;Molecular Conformation;multidisciplinary;mutant;Nitrates;novel;novel strategies;open data;Opiate Addiction;Pain;Pathway interactions;Periodicity;Peripheral;Pharmaceutical Preparations;pharmacologic;positive allosteric modulator;preference;Process;Program Research Project Grants;Property;protein structure;prototype;Pulmonary Fibrosis;Reaction;receptor;recruit;Research;Residual state;Roentgen Rays;Serine;Site;Structure;Testing;Therapeutic;therapeutic target;Tyrosine;Work;Yin-Yang

PROJECT_TITLE: Project 1 - Design and Synthesis of Novel Functionally Selective CB1 and CB2 Cannabinergic Ligands


NIH_SPENDING_CATS: Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Neurosciences;Substance Misuse;Therapeutic Cannabinoid Research

PI_NAMEs: BOHN, LAURA M. (contact)

PROJECT_TERMS: Active Sites;Affinity;Agonist;Allosteric Regulation;antagonist;antinociception;Binding;Biological;Biological Assay;Brain region;cannabimimetics;cannabinoid receptor;cannabinoid treatment;Cannabinoids;Cannabis;Cell Line;Cells;Cessation of life;Chemicals;Chemistry;clinical translation;CNR1 gene;CNR2 gene;Collaborations;Corpus striatum structure;cost;Cryoelectron Microscopy;Cyclic AMP;Data;design;Diabetic Nephropathy;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;Exhibits;Failure;Funding;Goals;GTP-Binding Proteins;improved;In Vitro;in vivo;in vivo evaluation;inflammatory pain;Knowledge;Learning;Legal;Ligands;Medicine;meter;Modeling;Molecular;Mus;Mutation;negative affect;Neurons;Neuropathy;Nociception;novel;pain relief;painful neuropathy;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physical Dependence;Plant natural product;positive allosteric modulator;pre-clinical;pre-clinical research;Preparation;Productivity;Property;Pulmonary Fibrosis;receptor;receptor function;Receptor Signaling;recruit;release of sequestered calcium ion into cytoplasm;side effect;Signal Pathway;Signal Transduction;Signaling Protein;Structure;System;Testing;Therapeutic;therapeutic target;Translating;Translations;Treatment Efficacy;United States;Work

PROJECT_TITLE: Project 2 - Molecular pharmacology of cannabinoid receptor probes


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative This prospective proteomics study will identify plasma proteins that contribute to increased risk of abdominal aortic aneurysm, to potentially improve the prevention, early management, and treatment of abdominal aortic aneurysm.

PI_NAMEs: TANG, WEIHONG  (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Abdominal Aortic Aneurysm;Adaptive Immune System;Age;Aorta;aptamer;Biological;Biological Assay;Biological Markers;biomarker identification;Black Populations;Blood Vessels;Brain natriuretic peptide;Cardiac;cardiovascular risk factor;circulating biomarkers;Clinical;cohort;cytokine;Data;Databases;Death Rate;Dyslipidemias;Ensure;Epidemiology;Etiology;Extracellular Matrix;FGF9 gene;Fibrin fragment D;Fibrinogen;follow-up;Funding;Gelatinase B;Gene Expression;Generations;Genes;genetic association;genetic variant;Genetic Variation;genome wide association study;Genomics;high risk;Human;Hypertension;IL6 gene;Impairment;improved;Individual Differences;Inflammation;Interleukin-6;International;Intervention;lifetime risk;liquid chromatography mass spectrometry;male;Matrix Metalloproteinases;Measurement;Mediator;men;Mendelian randomization;middle age;Morbidity - disease rate;mortality;N-terminal;never smoker;novel;older adult;Operative Surgical Procedures;Participant;Pathogenesis;Pathologic;Pathway Analysis;Pathway interactions;Peptide Hydrolases;Pharmacologic Substance;Plasma;Plasma Proteins;population based;Prevention;Preventive;Primary Prevention;prospective;Prospective Studies;Protease Inhibitor;protein biomarkers;Proteins;Proteomics;Publishing;repaired;Reporting;Resources;response;Risk;Risk Factors;Risk Marker;Ruptured Abdominal Aortic Aneurysm;Sampling;Scanning;screening;sex;Smoker;Smoking;Subgroup;Therapeutic;Thrombin;Troponin T;ultrasound;Up-Regulation;Visit

PROJECT_TITLE: Identifying Proteomics Risk Markers for Abdominal Aortic Aneurysm

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Uterine Cancer;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: RELEVANCE TO PUBLIC HEALTH The human SIN3A and SIN3B paralogues are members of several distinct chromatin remodeling complexes whose functions remain poorly understood. This is a critical gap in knowledge since SIN3A is routinely mutated in human cancers, SIN3B has been shown to be pro-metastatic, and decreased expression of both SIN3A and SIN3B have been linked to human neurodevelopmental disorders.

PI_NAMEs: WASHBURN, MICHAEL P (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;Affinity Chromatography;Area;Body of uterus;cancer type;Cell model;Cells;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Complex;crosslink;design;Development;driver mutation;Endometrial;Endometrial Carcinoma;Enzyme Kinetics;Enzymes;Fluorescence Microscopy;Foundations;Gene Expression;gene repression;Genomics;Goals;Hand;HDAC1 gene;HDAC2 gene;Histone Deacetylase;Histone Deacetylation;Human;human disease;interdisciplinary approach;Knowledge;Laboratories;Link;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;member;Methodology;Molecular;Multiprotein Complexes;Mutate;Mutation;Neurodevelopmental Disorder;novel;novel therapeutic intervention;paralogous gene;Peptide Synthesis;Peptides;Play;Positioning Attribute;protein complex;protein protein interaction;Proteomics;Public Health;Research;Role;Structural Models;Structure;Technology;Therapeutic Agents;Therapeutic Intervention;transcription factor;Vision

PROJECT_TITLE: Decoding the Assembly and Function of Paralogue Specific SIN3A and SIN3B Human Chromatin Remodeling Complexes and Networks

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Chronic Pain;Drug Abuse (NIDA only);Endocannabinoid System Research;Neurosciences;Pain Research;Substance Misuse;Therapeutic Cannabinoid Research

PI_NAMEs: HOHMANN, ANDREA GRACE (contact)

PROJECT_TERMS: 2-arachidonylglycerol;Active Sites;Affinity;Agonist;anandamide;animal pain;antagonist;Anxiety;Binding;Binding Sites;Biological;cannabimimetics;cannabinoid receptor;cannabinoid treatment;Cannabinoids;Cessation of life;Chemicals;Chemotherapy-induced peripheral neuropathy;Chronic;clinical translation;Clinical Trials;CNR1 gene;CNR2 gene;Complex;cost;Development;Dose;drug development;drug discovery;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;Exhibits;Failure;Future;G-Protein-Coupled Receptors;Human;improved;In Vitro;in vivo;in vivo evaluation;insight;Intoxication;Knockout Mice;Knowledge;knowledge base;Ligands;Medicine;Modeling;mu opioid receptors;Mus;negative affect;Neuropathy;Nociception;novel;Pain;pain model;Pathologic;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physical Dependence;positive allosteric modulator;pre-clinical research;preclinical study;preservation;Property;Proteins;Receptor Signaling;Research;side effect;Signal Pathway;Signal Transduction;Site;Stress;System;Testing;Therapeutic;therapeutic target;Translating;Translations;Treatment Efficacy

PROJECT_TITLE: Project 3 - In vivo pharmacology of cannabinoid receptor probes


NIH_SPENDING_CATS: Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Substance Misuse;Therapeutic Cannabinoid Research

PROJECT_TERMS: Active Sites;Advisory Committees;Agonist;Analgesics;Animal Model;antagonist;Antiinflammatory Effect;cannabinergic;cannabinoid receptor;Cannabinoids;CNR1 gene;CNR2 gene;Collaborations;Communication;Computer Assisted;Core Facility;cost;Databases;Development;Diabetic Nephropathy;Disease;drug discovery;Drug Kinetics;Endocannabinoids;Ensure;experience;Facility Designs;Funding;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Goals;Grant;Group Meetings;Growth;Human Resources;In Vitro;in vivo evaluation;Individual;Inflammatory;Joints;Laboratories;Ligands;meetings;Modification;multidisciplinary;mutant;novel;Occupational activity of managing finances;operation;Opioid Receptor;Pain management;Participant;Performance;pharmacologic;Preparation;Productivity;Program Research Project Grants;programs;receptor;Receptor Activation;Receptor Signaling;Records;Reporting;Research;Research Project Grants;Resource Sharing;Role;Signal Transduction;Structure;symposium;Telephone;therapeutic target;therapy development;Time;tool;Universities;Update

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Aplastic anemia is characterized by immune-mediated destruction of hematopoietic stem cells resulting in deficiency of blood cells of all lineages and therefore, immunosuppressive therapies has been the main line of treatment, which has significant relapse and refractory patients. Eltrombopag (Epag) has been developed as a small molecule thrombopoietin receptor (TPOR) agonist clinically used to improve platelet counts. Studies in AA showed that Epag treatment led to unexpected tri-lineage improvement and thereby more complete response which are in part due to its off-target effect on TET-dioxygenases that control cell lineage, differentiation and proliferation. We propose to study the novel stem cell activity of a known drug Epag, as TET inhibitor that can be exploited to study epigenetic regulation of HSC and to determine differences in the spectrum of effects from other thrombopoietic agents and to explain its effects or refractoriness in AA.

PI_NAMEs: JHA, BABAL K;MACIEJEWSKI, JAROSLAW P. (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Affect;Aftercare;Agonist;alpha ketoglutarate;analog;Anemia;Aplastic Anemia;Ascorbic Acid;base;Binding;Biochemical;Biological;Biological Models;Blood Cells;Bone marrow failure;bone marrow failure syndrome;Catalytic Domain;CD34 gene;Cell Line;Cell Lineage;Cells;Chemicals;Clinical;Clinical Data;Clinical Research;clinically relevant;cofactor;Coupled;Cryoelectron Microscopy;Crystallography;demethylation;Dependence;design;Dioxygenases;DNA;DNA methylation profiling;Elderly;Engraftment;Enhancers;Enzymes;Epigenetic Process;epigenetic regulation;extracellular;Failure;Gene Expression Profile;Gene Mutation;Genes;Hematology;Hematopoiesis;Hematopoietic;hematopoietic stem cell expansion;Hematopoietic stem cells;high throughput screening;Human;Hypermethylation;Idiopathic Thrombocytopenic Purpura;Immune;Immune mediated destruction;improved;In complete remission;In Vitro;in vivo;in vivo Model;Individual;inhibitor;Iron;Iron Chelating Agents;Iron Chelation;Kinetics;leukemia;loss of function mutation;Mediating;mimetics;Modeling;Molecular;mouse model;MPL gene;mRNA Expression;Mus;Myelogenous;Neoplasms;novel;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;Platelet Count measurement;polypeptide;Population;Production;Proliferating;promoter;Property;Proteins;Radiation;receptor-mediated signaling;Recovery;Refractory;Refractory anemias;Relapse;Residual state;Resolution;response;RNA;Role;Signal Transduction;small molecule;Somatic Mutation;stem cell expansion;stem cells;success;System;Testing;Therapeutic;Therapeutic immunosuppression;transcriptome sequencing

PROJECT_TITLE: Eltombopag: Novel Mode of Action on Normal and Aplastic Anemia Hematopoietic Stem Cells

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Sleep Research

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Both insomnia and chronically insufficient sleep have independently been shown to increase risk for the onset of depression by two- to three-fold, yet the functional mechanisms underlying the deterioration in emotion regulation following chronic sleep disruption remains unknown. Given that not all patients with insomnia experience an objective reduction in sleep duration, the goal of the present study is to determine the overlapping and distinct impact of Insomnia Disorder and multiple nights of truncated sleep in healthy controls on neural and behavioral responses during emotion regulation. The results will help us link different types of sleep disruption to neural signatures of emotional distress and will provide actionable therapeutic “targets” for future research investigating behavioral, pharmacological, and somatic (i.e., stimulation) treatments for patients struggling with sleep and emotional regulation.

PI_NAMEs: CUNNINGHAM, TONY J (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Acute;Adult;Amygdaloid structure;Anterior;Automobile Driving;Aversive Stimulus;Award;behavior test;Behavioral;behavioral response;biomarker identification;Brain region;career development;Chronic;Clinical;cohort;computerized data processing;coping;Data;Data Analyses;Data Collection;design;Deterioration;Development;Diagnosis;Discipline of Nursing;effective therapy;emotion dysregulation;emotion regulation;Emotional;emotional distress;emotional functioning;emotional reaction;Emotions;Etiology;experience;first responder;Functional disorder;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Goals;Grant;hazard;high risk;Hyperactivity;Impairment;improvement on sleep;Individual;Insula of Reil;K-Series Research Career Programs;Link;longitudinal design;Medical;Mental Depression;Mental disorders;Mentorship;Methodology;Military Personnel;Mood Disorders;mood regulation;Moods;multimodality;neural;neural circuit;neural correlate;neural network;Neurocognitive;novel therapeutics;Occupations;Outcome;Participant;Patient Recruitments;Patients;Pattern;pharmacologic;Play;Predisposition;Prefrontal Cortex;Process;Protocols documentation;recruit;Reporting;Research;Research Personnel;response;Rest;Risk;Risk Factors;Role;Sampling;skills;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep regulation;Sleeplessness;suicidal risk;Symptoms;therapeutic target;Time;Training;Translational Research;trend

PROJECT_TITLE: The Impact of Insufficient Sleep and Insomnia Disorder on Behavioral and Neural Markers of Emotion Regulation

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Kidney Disease;Pediatric;Prevention

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Despite the frequent use of ambulatory blood pressure monitoring (ABPM) in children with CKD, little is known regarding how nocturnal blood pressure (BP) dipping should be defined, its risk factors, and its consequences in this population. The objectives of this proposal are to 1) evaluate the association of nocturnal BP patterns with progression of kidney disease in children; 2) evaluate whether impaired daytime sodium excretion is associated with blunted nocturnal BP dipping, and 3) test whether nocturnal BP dipping can be restored simply with retiming of anti-hypertensive medication dosing to the evening. Results of this study will guide pediatric nephrologists on how to act on nocturnal dipping patterns in children with CKD, provide insights to its pathophysiology, and provide preliminary data for subsequent randomized trials to slow kidney disease progression in children with CKD.

PI_NAMEs: BAKHOUM, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: 14 year old;Adopted;Adult;adverse outcome;Albuminuria;Ambulatory Blood Pressure Monitoring;Anti-Hypertensive Agents;Biostatistical Methods;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure medication;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Child;Childhood;Chronic Kidney Failure;circadian;Clinic;Clinical;Clinical Practice Guideline;Clinical Trials;Clinical Trials Design;cohort;Cross-Over Studies;Data;Development;Diagnosis;Dialysis procedure;Diastolic blood pressure;Disease Progression;disorder risk;Diuretics;Doctor of Philosophy;Dose;early onset;Educational workshop;End stage renal failure;Excretory function;Foundations;Functional disorder;Future;Hemorrhage;high risk;Hour;Hypertension;Impairment;improved;insight;Intake;Kidney;Kidney Diseases;Life;Literature;Measurement;Mentors;Mentorship;modifiable risk;mortality;multidisciplinary;North America;Outcome;Pattern;Pediatrics;Pharmaceutical Preparations;Physiological;Population;Proteinuria;Randomized;randomized trial;Recommendation;recruit;Renal function;Research;Research Personnel;restoration;Risk;Risk Factors;Scientist;Severities;skills;Sodium;Testing;Training;Work

PROJECT_TITLE: Investigating the Significance of Nocturnal Blood Pressure Patterns in Children with Chronic Kidney Disease


NIH_SPENDING_CATS: Genetics;Nutrition

PHR: The proposed research is relevant to public health because it will define the roles of chromatin-mediated metabolic stability important for cell growth and development. As such, this research will develop new opportunities for epigenetic therapies in diseases emanating from metabolic dysfunction, such as diabetes, heart disease, and cancer.

PI_NAMEs: MORRISON, ASHBY J. (contact)

PROJECT_TERMS: Achievement;Biological;Cell Death;Cell division;cell growth;Cell Physiology;Cells;Chromatin;chromatin modification;Chromatin Remodeling Factor;Communication;Defect;detection of nutrient;Development;Diabetes Mellitus;Disease;Energy Metabolism;Energy Metabolism Pathway;Environment;Epigenetic Process;epigenetic therapy;Event;Failure;fitness;Gene Expression;Gene Expression Regulation;Goals;Growth;Growth and Development function;Heart Diseases;histone modification;Homeostasis;innovation;Investigation;Knowledge;Link;Malignant Neoplasms;Mediating;Memory;Metabolic;Metabolic dysfunction;Metabolism;microorganism;Nature;novel;Nutrient;Organism;Outcome;Pathway interactions;programs;Proliferating;Public Health;Research;response;Role;Signal Pathway;Tissues

PROJECT_TITLE: The Role of Chromatin in Metabolic Homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Disability Research

ORG_CITY: WORCESTER

ORG_NAME: WORCESTER POLYTECHNIC INSTITUTE

PHR: Project Narrative The proposed work will arm medicinal chemists with a new suite of chemical reactions that can expedite our society’s ability to synthesize small molecule therapies, a major bottleneck in our efforts to address critical health needs. The key strategy is predicated on using energy from visible-light to drive chemical transformations that may make life-saving therapeutics in an efficient, robust and enabling manner. The motivation for our work is to protect life by lowering the barrier to making pharmaceutical compounds that will treat diseases, reduce disabilities, and enhance the quality of life.

PI_NAMEs: MUSACCHIO, PATRICIA ZHANG (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Mild Strategies in the Direct Generation of Carbocation Intermediates from C(sp3)–H Bonds

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurodegenerative;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project Narrative A multitude of chemical modifications influence the structure and function of RNA, which is central to cell function across life, in both health and disease. We will investigate how prion protein-based control of RNA-modifying enzymes affects RNA structure, gene expression, and cell growth. The proposed work will uncover a new understanding of how RNA structure can be epigenetically controlled.

PI_NAMEs: GARCIA, DAVID M. (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TITLE: Prion-based regulation of RNA-modifying enzyme activities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


ORG_CITY: NEW ORLEANS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Chronic inflammation associated with HIV infection increases the risk of developing a range of comorbidities, including diabetes, kidney/liver disease and cardiovascular disease. This study proposes to identify the mechanisms of dysregulation in the intestinal epithelial barrier protective functions of gamma delta T cells and to explore the potential therapeutic effects of microbial supplementation for restoring gut barrier integrity using the highly translational nonhuman primate model of chronic treated HIV infection. Validating this approach could benefit multiple inflammatory diseases, an important goal in restoring general health.

PI_NAMEs: ROUT, NAMITA  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, KHOA DINH DANG

PROJECT_TERMS: Affect;Age related comorbidities;aging related;Anti-Inflammatory Agents;antiretroviral therapy;Bacteria;Biological Assay;Biological Markers;Biopsy;bisphosphonate;Cardiovascular Diseases;Cardiovascular system;Cell Physiology;Cells;Chronic;clinical development;Coculture Techniques;combinatorial;comorbidity;cytokine;Development;Diabetes Mellitus;Disease;dysbiosis;Epithelium;experience;fecal transplantation;Frequencies;Functional disorder;gastrointestinal epithelium;Gene Expression Profile;Genetic Transcription;Goals;gut homeostasis;gut microbes;gut microbiome;Gut Mucosa;Health;Hepatic;High Prevalence;HIV;HIV Infections;Homeostasis;Human;IL17 gene;Immune;immune activation;immune function;immunoregulation;improved;In Vitro;in vivo;Incidence;Individual;Infection;Inflammation;Inflammatory;inflammatory marker;Interleukin-15;Interleukin-2;interleukin-22;Intervention;intestinal epithelium;Intestines;Joints;Kidney;Kidney Diseases;Leaky Gut;Link;Liver diseases;Macaca;Maintenance;Malignant Neoplasms;Mediating;Metabolic Diseases;microbial;microbiome;Modeling;Molecular;Mucous Membrane;Neurocognitive Deficit;nonhuman primate;novel;Outcome;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;prevent;Process;repaired;Reporting;Research;Residual state;Resolution;Risk;Role;Science;simian human immunodeficiency virus;SIV;Supplementation;systemic inflammatory response;T-Lymphocyte;Testing;Therapeutic Effect;transcriptome sequencing;Treponema;Viral;Viral Load result;Virus Diseases;Zoledronate;γδ T cells

PROJECT_TITLE: Gamma Delta T cell and microbial modulation to target chronic SIV-associated inflammation

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE By taking a complex systems approach, we can assess how physical activity behavior determinants operate in combination over time and differ across children to inform physical activity interventions and policies. Given pronounced health disparities in physical activity behaviors (and common chronic diseases that could be improved and/or prevented through physical activity) actions tailored to maximize impact could be a powerful health disparities reduction strategy.

PI_NAMEs: BARKIN, SHARI  (contact);HAMMOND, ROSS A.

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Accelerometer;Adult;Affect;Age;aged;American;Behavior;behavioral study;Biological Models;Biomedical Research;Body mass index;bone;built environment;cardiovascular health;Characteristics;Child;Child Development;Childhood;Chronic Disease;Cognitive;cognitive process;community setting;Complex;Data;Data Set;Development;disorder prevention;Disparity;Disparity population;disparity reduction;dynamic system;early childhood;Ecology;Elements;Ethics;ethnic diversity;Ethnic Origin;Ethnic Population;Etiology;exercise intervention;Family;Future;Gender;Guidelines;Health;health disparity;Health Promotion;Heterogeneity;Home;improved;Individual;insight;Institution;Intervention;Literature;longitudinal dataset;low socioeconomic status;Metabolic;Minority Groups;Modeling;mortality;novel;Outcome;Parameter Estimation;Parents;Pathway interactions;Pattern;Pattern Formation;Physical activity;Physical assessment;physical conditioning;Policies;policy recommendation;Population;Population Heterogeneity;prevent;Prevention strategy;psychosocial;Race;racial diversity;racial population;Recommendation;Reduce health disparities;response;Risk;Shapes;skeletal;Social Environment;Social Sciences;System;Target Populations;Tennessee;Testing;Time;Underserved Population;Variant

PROJECT_TITLE: Early Childhood Physical Activity: A Dynamic Systems Approach to Reducing Health Disparities

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Sleep is a key determinant of human health and disease. Manipulation of brain circuits in model systems can reveal the mechanisms underlying sleep and lead to novel therapies. Here, we will develop a new technology to interrogate sleep circuits wirelessly and with greater precision relative to ongoing brain activity than previously possible.

PI_NAMEs: LIU, XILIN ;RICHARDSON, ANDREW GARMORY (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Acceleration;Acoustic Stimulation;Address;Affect;Agreement;algorithm training;Amplifiers;analog;Animal Model;Animals;Auditory;Behavior;Biological Models;Bite;Brain;Canis familiaris;Charge;Classification;cognitive benefits;Communities;Data;data acquisition;Data Analyses;Data Compression;data exchange;design;Devices;digital;Disease;Electric Stimulation;Electrophysiology (science);energy efficiency;experience;experimental study;Eye;Family suidae;Felis catus;free behavior;Health;Home;Housing;Human;hypocretin;Immune;improved;in vivo;in vivo evaluation;industry partner;Intervention;Investigation;Label;Learning Module;Light;long term memory;Macaca;Machine Learning;Metabolic;microelectronics;microsystems;miniaturize;Modeling;Modification;Monkeys;multimodality;Mus;Muscle;neural;neural circuit;Neurodegenerative Disorders;Neurons;neurotransmission;new technology;Noise;non rapid eye movement;nonhuman primate;noradrenergic;novel therapeutic intervention;novel therapeutics;operation;Optics;optogenetics;Performance;Phase;Physiological;Physiology;Play;Polysomnography;prevent;Process;Qualifying;Radio;rapid eye movement;Rattus;REM Sleep;Research;Rodent;Role;Running;Scientist;Sensory;Signal Transduction;Silicon;Sleep;Sleep Architecture;sleep behavior;Sleep Disorders;sleep regulation;Sleep Stages;Specificity;System;Techniques;Technology;Testing;Time;Wakefulness;Weight;wireless;wireless communication;wireless data transmission;wireless electronic

PROJECT_TITLE: A wireless closed-loop sleep modulation system-on-chip

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Understanding control of gene expression requires comprehensive identification of both the functional regulatory elements encoded on the RNAs and the identification of the proteins that bind to them. Here we develop a novel scalable technology, reagent resource, experimental protocols and a computational framework for detecting RBP-RNA targets and translation at the single-cell and single-molecule levels. Our conceptual and technological innovations will, for the first time, enable translation efficiency and RBP-interactomes to be measured at single-cell level and at scale, opening up new paradigms of biological questions.

PI_NAMEs: YEO, EUGENE WEI-MING (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Adoption;Amino Acids;analytical tool;Antibodies;apoB mRNA editing catalytic subunit;Binding;Binding Proteins;Binding Sites;Biological;Birth;cell type;Cells;Collection;Communities;computer framework;Coupled;crosslink;Data;Data Set;design;Detection;detection limit;Disease;Elements;flexibility;Gene Expression;Genomics;Goals;Grant;Human;Immunoprecipitation;improved;insight;Label;Libraries;Life Cycle Stages;Ligation;Locales;Maps;Measurement;Measures;Mediating;Messenger RNA;Metabolism;Methodology;Methods;Modification;Molecular;Monitor;Morphologic artifacts;mRNA Translation;nanopore;National Human Genome Research Institute;Nature;new technology;Noise;novel;paralogous gene;programs;Protein Isoforms;Protein Subunits;Protocols documentation;Reagent;Regulatory Element;Reproducibility;Research;Resolution;Resources;response;Ribosomal Proteins;ribosome profiling;Ribosomes;RNA;RNA Processing;RNA-Binding Proteins;RNA-Protein Interaction;Role;Sampling;Signal Transduction;single cell analysis;single molecule;Site;Specificity;Surveys;technological innovation;Technology;technology development;Testing;Third Generation Sequencing;Time;Transcript;transcriptome;transcriptome sequencing;Translations;Untranslated RNA;Work

PROJECT_TITLE: STAMP technology to enable single-cell and isoform-sensitive detection of RBP sites

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-B(50)R]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Brain Disorders;Eating Disorders;Mental Health;Mental Illness

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Eating disorders are serious conditions associated with significant mortality, necessitating innovative research to determine causes, maintenance factors, prevention, and treatment. This multisite T32 postdoctoral fellowship program trains the next generation of scientists in interdisciplinary research methods through mentorship, teaching, and experiential learning opportunities in order to advance the science of eating disorder psychopathology and related conditions.

PI_NAMEs: PETERSON, CAROL B. (contact)

PROJECT_TITLE: Regional Postdoctoral Training Grant in Eating Disorders Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (01)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lung;Neurodegenerative;Neurosciences;Sarcopenia

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Respiratory dysfunctions (including those of the tongue, chest wall, abdominal diaphragm muscles) and increased incidence of airway infections are major contributors to morbidity and mortality in Alzheimer’s disease and aging. The exact mechanisms of how respiratory muscles are compromised with Alzheimer’s disease and aging is unknown, but likely involves all levels of the motor unit, the motor neuron pools in the brainstem and spinal cord and the skeletal muscle. This project will assess two major culprits in neural loss and muscle weakness at all levels of the motor system, investigating therapeutic strategies designed to mitigate the effects of synaptic dysfunction (SPG302) and mitochondrial disfunctions (edaravone).

PI_NAMEs: FOGARTY, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Abdomen;Abdominal Muscles;Address;Affect;Age;age group;age related;age-related disease;age-related muscle loss;Aging;aging related;aging related disease;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-Protein;Amyotrophic Lateral Sclerosis;Behavior;Brain Stem;Central Nervous System;Cessation of life;Chest;Chest wall structure;Chronic Disease;Data;Deglutition;Dendritic Spines;Denervation;density;design;Disease;Elderly;Excitatory Synapse;experience;Experimental Designs;Fiber;Functional disorder;Functional impairment;functional improvement;gamma-Aminobutyric Acid;Generations;Genetic;Glutamates;Human;human old age (65+);Image;Impairment;improved;improved outcome;Incidence;Individual;Inflammaging;Inhibitory Synapse;innovation;Knowledge;Maintenance;Membrane;Mitochondria;mitochondrial dysfunction;Morbidity - disease rate;mortality;Motor;motor control;motor impairment;Motor Neurons;Muscle;Muscle Fibers;Muscle function;Muscle Weakness;Muscular Atrophy;muscular system;Nerve Degeneration;neural;Neuromuscular Junction;neuromuscular system;neuron loss;normal aging;novel;novel therapeutic intervention;Obstructive Sleep Apnea;oral motor;Oranges;Outcome;Oxidative Stress;phenylmethylpyrazolone;Pneumonia;Population;preservation;pressure;Publishing;Rattus;recruit;Research;resilience;Respiration;Respiration Disorders;respiratory;Respiratory Diaphragm;Respiratory Muscles;Respiratory Tract Infections;Risk;Risk Factors;Rodent;sarcopenia;Severities;Skeletal Muscle;Spinal Cord;Symptoms;Synapses;synaptic function;System;tau Proteins;Techniques;Testing;Therapeutic;Tongue;Work

PROJECT_TITLE: Ameliorating Respiratory Neuromotor Dysfunctions in Aging and Alzheimer's Disease

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Narrative The program meets the demands for conceptual understanding and quantitative rigor of modern neuroscience. Training that promotes rigorous literacy in experimental design, data analysis and quantitative methods applied to neuroscience will prepare new generations of innovators who will make a positive impact on the field. Supported by committed mentors, a program that fosters a diverse and inclusive training environment, and effective career advising, trainees will be placed at a competitive edge for a variety of careers in STEM disciplines within and outside of academia.

PI_NAMEs: MAFFEI, ARIANNA  (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TITLE: Training Program in Neuroscience at Stony Brook University: Fostering Quantitative Literacy and Experimental Rigor

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (03)]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: RELEVANCE STATEMENT Addressing the social determinants of health is a key strategy to improve population health and address health inequities. This training program will provide nurses from diverse and underrepresented backgrounds with specialized research training in developing, testing, and scaling nurse-led models of care that address the social determinants of health.

PI_NAMEs: GONZALEZ-GUARDA, ROSA MARIA (contact);SHAW, RYAN JEFFREY

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TITLE: Nurse LEADS: Training in Nurse-LEd models of care ADdressing the Social Determinants of Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZNR1 REV-N (03)]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases

ORG_DEPT: VETERINARY SCIENCES

PHR: PROJECT NARRATIVE There continues to be a serious shortage of academic, industry and government veterinarians who have the background to do independent biomedical research. The T35 training program "Veterinary Summer Scholars in Comparative Medicine" VSSCM at the University of Minnesota will introduce veterinary students to biomedical research and training. Our goal is to increase the numbers of researchers in the veterinary-scientist pipeline to benefit human health.

PI_NAMEs: PATTERSON, EDWARD E (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Affect;Anatomy;Animal Diseases;Animal Model;Animals;Area;Biomedical Research;Career Choice;Clinical Sciences;Collaborations;Communication;comparative;Conflict (Psychology);Dentistry;Disease;Ecosystem;Emerging Communicable Diseases;Environment;Ethics;experience;Experimental Designs;faculty mentor;food security;Grant;Health;Health Professional;Health Sciences;Human;human disease;human model;innovation;Knowledge;lectures;Medicine;Mentors;Minnesota;multidisciplinary;National Research Council;Pharmacology;Pharmacy facility;Physicians;Physiology;programs;quality assurance;Reporting;Research;Research Infrastructure;Research Personnel;Research Training;Role;Schools;Science;Scientist;Students;Technical Expertise;Training;Training Programs;Translational Research;United States National Institutes of Health;Universities;Veterinarians;Veterinary Medicine;Veterinary Schools;welfare;working group;Zoonoses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-J (80)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: The Scanning electron microscope (SEM) is an essential tool to study tissue structure and local elemental components in tissues and cells. The SEM available within the CBI is over 20 years old and will no longer be supported by the manufacturer and needs to be retired. This together with a defined need for more sophisticated analytical imaging modalites (EDS) by our NIH funded user population is driving this request to place a contemporary high quality SEM in the Center for Biologic Imaging to allow practical application of SEM imaging modalities tools to the largest number of NIH funded investigators here at the University of Pittsburgh.

PI_NAMEs: WATKINS, SIMON C (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Age;Back;Biological;Computer Systems;Contract Services;Core Facility;Devices;Electron Microscope;Electron Microscopy;Funding;Hour;Image;Image Analysis;imaging facilities;improved;Institution;instrument;Letters;Life Cycle Stages;light microscopy;Maintenance;Manufacturer;medical schools;Microscope;Performance;Research;Research Personnel;Research Support;Resolution;Scanning;Services;Speed;System;Technology;Time;Training;United States National Institutes of Health;Update

PROJECT_TITLE: JEOL JSM-IT700HRLA Scanning Electron Microscope

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-B (30)]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Immunotherapy;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: BAYAMON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSIDAD CENTRAL DEL CARIBE

ORG_STATE: PR

PHR: This project aims to improve immunotherapeutic outcomes for glioblastoma (GBM) patients by investigating the role of Pyk2 and FAK signaling in regulating PD-L1 expression in GBM and their impact on the tumor immune microenvironment. The study will explore the potential of Pyk2/FAK inhibitors as sensitizers for anti-PD-L1 therapy in GBM, considering the importance of incorporating the NF1 status of the tumor in treatment decisions. The findings will contribute to personalized therapeutic approaches and treatment choices, with the goal of enhancing outcomes for GBM patients.

PI_NAMEs: KUCHERYAVYKH, LILIA  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: anti-PD-L1 therapy;anti-tumor immune response;Antigens;Brain;brain tissue;C57BL/6 Mouse;CD8-Positive T-Lymphocytes;Cell Culture Techniques;Cell Fraction;Cell Line;Cell membrane;Cells;Cellular biology;Clinical Trials;clinically significant;Combined Modality Therapy;confocal imaging;Coupled;CRISPR/Cas technology;cytokine;Data;Development;Diagnosis;Effectiveness;effectiveness evaluation;Environment;Evaluation;Exhibits;Flow Cytometry;Focal Adhesion Kinase 1;Gene Transfer;Glioblastoma;Goals;Homing;Human;Image;immune checkpoint blockade;Immune checkpoint inhibitor;Immunofluorescence Immunologic;Immunosuppression;Immunotherapeutic agent;Immunotherapy;implantation;improved;Individual;Infiltration;Inflammatory;Inflammatory Infiltrate;kinase inhibitor;knock-down;Knock-out;Laboratories;Malignant neoplasm of brain;Malignant Neoplasms;Measures;Mediating;Microglia;Modeling;mouse model;Mus;Myeloid Cells;Neurofibromatosis 1;Outcome;Patients;PDGFA gene;PDGFB gene;PDL1 inhibitors;pembrolizumab;Peripheral;personalized medicine;personalized therapeutic;pharmacologic;Population;Primary Cell Cultures;programmed cell death ligand 1;Proto-Oncogene Proteins c-akt;PTK2B gene;Recurrence;Regulation;response;Reverse Transcriptase Polymerase Chain Reaction;rho;Role;Sampling;Signal Pathway;Signal Transduction;Small Interfering RNA;Specimen;STAT3 gene;success;Survival Rate;System;Testing;Therapeutic;therapy outcome;TP53 gene;treatment choice;Treatment outcome;treatment response;tumor;tumor growth;tumor-immune system interactions;Tumor-infiltrating immune cells;Western Blotting

PROJECT_TITLE: Pyk2 inhibition mitigates immunosuppressive environment and enhances therapeutic response to immune checkpoint inhibitors in GBM

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-4 (SU)]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE This proposal requests supplemental funding to support a minority graduate student as part of an existing U54 SCORE program exploring the long-term changes in brain function following in utero stress and inflammation. Overexposure to inflammation or to glucocorticoids can disrupt fetal development and program autonomic dysregulation and elevated risk for neuropsychiatric disorders in adulthood. The proposed research will investigate whether puberty is a critical period for autonomic nervous system development that may be altered by prenatal stressors.

PI_NAMEs: GOLDSTEIN, JILL M (contact);TOBET, STUART A.

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: Adrenal Glands;Adult;Affect;Age;Agonist;Anxiety;Arizona;Autonomic nervous system;Behavioral;Blood Pressure;Brain;Cardiac;cardiogenesis;Cardiometabolic Disease;Cardiovascular system;Complex;critical developmental period;critical period;Data;Development;Dexamethasone;Disease;Disproportionately impacts women;Education;Environment;Exposure to;Female;fetal;Fetal Development;fetal programming;Foundations;Funding;Glucocorticoids;Goals;Health;Heart Rate;Homeostasis;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Immune;Impairment;in utero;Inflammation;Laboratories;Lead;Major Depressive Disorder;male;Mediating;member;Mental Depression;Minority Graduate Student;Mission;nervous system development;neural;neuropsychiatric disorder;Parasympathetic Nervous System;Peripheral;Predisposition;Pregnancy;prenatal;prenatal exposure;prenatal stress;programs;Puberty;Rattus;Reflex action;Regulation;Request for Proposals;Research;resiquimod;response;Risk;Rodent;Sex Differences;social;Stress;stressor;Sympathetic Nervous System;System;Testing;TLR7 gene;Training Programs;Universities;Withdrawal;Work

PROJECT_TITLE: Prenatal immune programming of sex differences in depression and CVD risk. Supplement to Sex Differences in Major Depression: Impact of Prenatal Stress-Immune and Autonomic Dysregulation.


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE The Neurodegeneration Training Program provides training to outstanding predoctoral students to become leaders of academic, clinical, or pharmaceutical research programs focused on neurodegeneration. The program emphasizes rigorous and quantitative neurodegeneration research, mentored clinical experience with patients, and career development skills necessary for making successful translational advances for maintaining a healthy aging population.

PI_NAMEs: ZHU, XIONGWEI  (contact)

PROJECT_TERMS: Neurodegenerative Disorders;Training

PROJECT_TITLE: Training in Neurodegenerative Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-R (15)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE This project will give young epidemiologists, biostatisticians, health services researchers, genetic epidemiologists, and pharmaceutical outcomes researchers the training they need to access and analyze the wealth of data that are available to address the growing burden of cancer.

PI_NAMEs: SCHWARTZ, STEPHEN M (contact);WU, MICHAEL CHIAO-AN

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TITLE: Developing Data-Driven Cancer Researchers

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-R (J1)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_NAME: LSU HEALTH SCIENCES CENTER

PHR: Project Narrative ______ The Medical Student Alcohol Research Internship (MSARI) at LSUHSC-New Orleans is designed to cultivate student interest and aptitude for scientific research careers by preparing them to work on innovative research projects related to alcohol use disorder (AUD) and alcohol-related diseases. This program will equip the next generation of physician-scientists to conduct the translational research that can transform basic science discoveries into new clinical therapies for AUD-related conditions.

PI_NAMEs: EDWARDS, SCOTT ;MOLINA, PATRICIA E. (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Alcohol abuse;Alcohol consumption;alcohol research;alcohol use disorder;Alcohols;Animals;ARHGEF5 gene;Basic Science;Behavioral;Biomedical Research;career;Career Choice;comorbidity;design;Doctor of Philosophy;Drug abuse;Environmental Risk Factor;Evaluation;experience;Funding;Goals;improved;Individual;Infrastructure;Instruction;interest;Internships;matriculation;Measures;medical schools;Medical Students;Medicine;meetings;Mentors;National Institute on Alcohol Abuse and Alcoholism;next generation;Oral;Participant;peer coaching;Physicians;Physiology;Postdoctoral Fellow;posters;Professional Competence;programs;Reagent;recruit;Reproducibility;Research;Research Personnel;responsible research conduct;Risk;Safety;student participation;Students;success;summer internship;summer research;Surveys;Training;Training Programs;Translational Research;Woman;Work;Writing

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 CC (32)]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative The mission of the Duke Neurobiology Training Program (NBTP) is to train the next generation of leading scientists who will discover how the nervous system normally functions to enable a myriad of complex processes, including learning, memory, movement, behavior, sensation, and perception, and how to restore normal function of the nervous system in the face of trauma and disease. The major objective of the NBTP is to endow young scientists with the intellectual breadth, technical flexibility and scientific rigor to grow and adapt to the demands of neuroscience research now and over the next several decades, enabling them to successfully navigate the variety of scientific career paths that will span the neuroscience research enterprise of the future.

PI_NAMEs: MOONEY, RICHARD D (contact)

PROJECT_TERMS: Neurobiology;Training Programs

PROJECT_TITLE: Neurobiology Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (09)]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PHR: Project Narrative This training program is designed to give its predoctoral students and postdoctoral fellows essential skills in the study of addiction neuroscience. Trainees are expected to develop novel research projects that will provide important new insights to the mechanisms of actions of addictive drugs and their associated behaviors. These insights are expected to lead to new therapeutic tools for the treatment and prevention of drug addiction.

PI_NAMEs: FERGUSON, SUSAN MARIE;PHILLIPS, PAUL E. M. (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: addiction;Neurosciences;Training

PROJECT_TITLE: Training in Addiction Neuroscience

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 MXS-T (J1)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: LOS ANGELES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Remaining at the forefront of cutting-edge technologies to understand the human condition, the UCLA Medical & Imaging Informatics (MII) training program aims to train and inspire a new generation of scientists who will lead the development of innovative approaches that inform and enable the translation and analysis of these methods into practice. MII establishes a cross-campus, interdisciplinary environment to teach and mentor future scientists in novel computational and data science methods for new types of sensing and imaging data; and creates novel, team science research opportunities in which graduate students work and learn from leading experts in the field. MII trainees are exposed to the breadth of contemporary research, and are ultimately pre- pared to be productive, independent scientists that will participate in shaping the discipline as biomedical re- search and healthcare evolve.

PI_NAMEs: BUI, ALEX  (contact);HSU, WILLIAM ;PROSPER, ASHLEY E

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TITLE: Medical Imaging Informatics Training Grant

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-D (J1)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

PHR: Project Narrative Research Training in Rheumatology at the Massachusetts General Hospital is designed to prepare the next generations of research scientists who, through mentored research and rigorous training in new technologies, are prepared to be leaders in rheumatology related biomedical research. The overall goal of this program is to educate trainees so that they can contribute to our understanding of the pathogenesis of rheumatic diseases, and translate these findings to better clinical care for patients with these important diseases.

PI_NAMEs: LUSTER, ANDREW D (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TITLE: Research Training in Rheumatology at Massachusetts General Hospital

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 SP (M1)]


ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE There is a critical need for surgeons knowledgeable in the clinical aspects of oncology and skilled in modern scientific methods that will provide novel approaches to the understanding and treatment of cancer. Development of highly skilled surgeon scientists requires dedicated time for research training and mentorship experience, which will be provided to residents and fellows who participate in the proposed training program.

PI_NAMEs: ALLEN, PETER J;HARPOLE, DAVID H. (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Research Training;Surgical Oncology;Training Programs

PROJECT_TITLE: Duke Research Training Program in Surgical Oncology

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE The huge volume of data continually produced by genomic and related projects offers enormous opportunities for improving our understanding of human health and alleviating disease. The UCSF Biological and Medical Informatics (BMI) Training Program aims to train a new generation of diverse scientific leaders at the interface of computation, statistics, and biology who will be needed to make effective use of these data.

PI_NAMEs: HERNANDEZ, RYAN D. (contact)

PROGRAM_OFFICER_NAME: DAVANI, BEHROUS

PROJECT_TITLE: BMI Bioinformatics Training Grant

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Pediatric

ORG_CITY: WASHINGTON

ORG_NAME: AMERICAN ACADEMY-CHILD/ADOLESCENT PSYCH

ORG_STATE: DC

PHR: Project Narrative: The number of child and adolescent psychiatry (CAP)-trained/committed physicians pursuing a research career is declining paradoxically at a time when there is greater need for CAP physician/scientists to advance the NIMH Strategic Plan, including increasing recognition that neuropsychiatric illnesses are often disorders of neurodevelopment, starting early in childhood/adolescence. The Child and Adolescent Psychiatry Research Institute (CAPRI) will create a national mentoring network: (1) linking early career CAP-trained/committed researchers (CAPRI Scholars) to established CAPRI Mentors for a 2-year mentorship program of overlapping cohorts, engaging in a 3-day in-person meeting plus ongoing webinars and regular 1:1 mentor meetings throughout the academic year; (2) providing mentorship for pre-contemplative CAP physicians not yet ready to apply for a K-award in preparation to become Scholars; and (3) providing sustaining mentorship for AACAP Summer Medical Students to increase their likelihood of choosing psychiatry and ultimately CAP as a career. CAPRI will mentor the next generation of CAP researchers, increasing their success in obtaining career development awards, launching their careers to improve mental health, and providing a sustainable support network and social belonging.

PI_NAMEs: DICKSTEIN, DANIEL P (contact);FORTUNA, LISA R;SINGH, MANPREET K

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Academy;Address;Adolescence;Adolescent;adolescent mental health;Adolescent Psychiatry;Adult;Aging;Ally;American;Award;Basic Science;Behavior;Big Data;Brain;career;career development;Child;Child Mental Health;Child Psychiatry;Child Support;Childhood;clinical translation;cohort;Collaborations;Communication;Communities;Consultations;COVID-19;COVID-19 pandemic;Development;disadvantaged background;Discipline;Disease;Disparity;Distal;diversity and inclusion;Doctor of Philosophy;Early Diagnosis;Education Projects;Engineering;Ensure;equity, diversity, and inclusion;Ethnic Origin;experience;Faculty;Feedback;Fostering;Foundations;Gender;Genes;Goals;Grant;Home;implementation science;improved;innovation;Institute of Medicine (U.S.);Institution;Interdisciplinary Study;Intervention;K-Series Research Career Programs;Knowledge;Lawyers;Learning;life span;Link;Mediation;Medical Students;Medicine;meetings;member;Mental disorders;Mental Health;Mentored Clinical Scientist Development Program;Mentors;Mentorship;multidisciplinary;National Institute of Drug Abuse;National Institute of Mental Health;neurodevelopment;neuropsychiatry;next generation;online community;Online Systems;Outcome;Paper;peer;peer support;Persons;Physicians;Preparation;Prevention strategy;primary outcome;programs;promote resilience;Psychiatrist;Psychiatry;Public Health;Publications;Publishing;Race;Recommendation;recruit;Research;Research Institute;Research Personnel;Residencies;response;responsible research conduct;Science;Scientist;secondary outcome;Services;skills;social;Strategic Planning;success;support network;Surgeon;Surveys;Time;Time Management;Training;treatment strategy;Underrepresented Minority;United States National Academy of Sciences;video chat;virtual;webinar;Woman;Writing;Youth

PROJECT_TITLE: Child and Adolescent Psychiatry Research Institute (CAPRI): A National Child/Adolescent Psychiatry Research Mentorship Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (01)]


ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Cryogenic electron microscopy (cryo-EM) is essential for studying biological structures at high resolution from molecular to cellular scales. The requested electron imaging filter system will dramatically improve data quality, especially for imaging thick cellular samples or critical small protein targets. This cryo-EM upgrade will significantly advance the knowledge and boost research productivity in biomedicine and fundamental biology.

PI_NAMEs: CHIU, PO-LIN  (contact)

PROJECT_TERMS: Arizona;Biology;Biomedical Research;Cellular biology;Communities;Computer software;Cryoelectron Microscopy;Crystallography;Data;data quality;Drug Design;electron energy;Electron Microscope;Electron Microscopy;Electron Microscopy Facility;electron tomography;Electrons;experience;Funding;Generations;Image;Image Enhancement;image reconstruction;improved;In Situ;instrument;Investigation;Knowledge;Leadership;Medical;Membrane;microscopic imaging;nanomedicine;Noise;particle;Productivity;protein complex;Proteins;reconstruction;Recording of previous events;Records;Research;Research Personnel;Resolution;Sampling;Signal Transduction;Specimen;structural biology;Structure;Suggestion;System;temporal measurement;Thick;United States National Institutes of Health;Universities

PROJECT_TITLE: Electron Energy Filtering System for Cryo-EM Imaging


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Genomic instability gives rise to aging, tumor evolution, DNA repeat expansion associated with multiple disease states, the development of antibiotic resistance in bacteria, and a general reduction in evolutionary fitness. This proposal addresses the molecular basis of an essential yet too often overlooked source of genomic instability, the repair of lesions in post-replication gaps that are left behind the replication fork. As gap repair is a primary source of mutagenesis and genomic rearrangements, we are proposing an integrated strategy to attain an in-depth understanding of gap formation and repair, aimed at providing new avenues to slow tumor growth and bacterial antibiotic resistance. Our project will address four separate vulnerabilities of bacterial pathogens that may eventually be used to address antiobiotic-resistand pathogens, one of them newly discovered.

PI_NAMEs: COX, MICHAEL M. (contact);GOODMAN, MYRON ;KECK, JAMES L

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Aging;Antibiotic Resistance;Antibiotics;Bacteria;Bacterial Antibiotic Resistance;Bacterial Genome;Binding;Binding Proteins;Biochemistry;biological adaptation to stress;Biological Phenomena;Biophysics;Bypass;Cells;Closure by clamp;Collaborations;Complex;Development;Disease;DNA;DNA biosynthesis;DNA lesion;DNA metabolism;DNA polymerase V;DNA Repair;DNA Repair Gene;DNA Repair Pathway;DNA Repeat Expansion;DNA replication fork;DNA Sequence;DNA Sequence Rearrangement;DNA-Directed DNA Polymerase;Elements;emerging pathogen;Ensure;Enzymes;Escherichia coli;Eukaryota;Event;Evolution;Excision Repair;Expanded DNA Repeat;fitness;Funding;Genetic;Genetic Recombination;Genome;Genomic DNA;Genomic Instability;Genomics;grasp;Growth;Homologous Gene;in vivo;insight;Left;Lesion;Link;Location;Maintenance;Malignant Neoplasms;Methodology;Methods;Molecular;Molecular Biology;Monitor;Mutagenesis;novel;Nucleotides;pathogen;pathogenic bacteria;Pathogenicity;Pathway interactions;Pattern Formation;Pharmacologic Substance;Phase;Positioning Attribute;Process;protein function;Proteins;reconstitution;repaired;Replication Initiation;Research;Resolution;Risk;Role;single molecule;Single-Stranded DNA;SOS Response;Source;SS DNA BP;System;Time;tool;tumor;tumor growth;Work

PROJECT_TITLE: Creation and Repair of Postreplicative DNA Gaps

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-G (50)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Mental Health

ORG_CITY: INDIANAPOLIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative This pilot study will design and develop a mobile application (SuperAssist) to implement and support Client- Centered Supervision (CCS) in order to improve mental health workforce outcomes and quality of care for clients, which may lead to improved client outcomes. SuperAssist aims to structure supervision to help front- line mental health providers and their supervisors focus on client goal achievement while also addressing providers’ challenges on the job. The SuperAssist training manual will promote wider dissemination and adaptation to different service settings where quality supervision is needed to deliver client-centered practices.

PI_NAMEs: FUKUI, SADAAKI  (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: Achievement;Address;Affect;burnout;Case Manager;Client;Collaborations;Communities;community engaged research;Complex;Control Groups;Data;Data Collection;data sharing;design;Development;Dimensions;effectiveness testing;experience;experimental group;Feedback;flexibility;Foundations;Future;Goals;Health Personnel;Health system;High Prevalence;high risk;Human;improved;improved outcome;innovation;Interview;Job Satisfaction;Leadership;Manuals;meetings;Mental Health;mental health organization;Mental Health Services;Methods;mobile application;Modeling;Monitor;National Institute of Mental Health;Occupations;Outcome;Outcome Measure;Personal Satisfaction;Pilot Projects;Play;Population;practice setting;primary outcome;Process;Process Measure;Provider;Quality of Care;Questionnaires;Randomized, Controlled Trials;Readiness;Recovery;recruit;Research Priority;response;Role;routine practice;Schedule;Service delivery model;Service setting;Services;skill acquisition;skills;smartphone application;Stress;Structure;success;Supervision;support tools;Surveys;Technology;Testing;tool;Training;treatment as usual;United States;usability;Vertebral column;Visual

PROJECT_TITLE: SuperAssist: Client-Centered Supervision Assist App for Mental Health Providers to Improve Job Well-being and Quality of Care

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

PHR: Narrative Environmental chemicals and stressors are major contributors to disease; interdisciplinary expertise is required to rigorously quantify exposure and health effects to assess and manage risk, as well as to develop novel tools for reduction of exposure, remediation of polluted sites, and treatment of disease. Duke University has outstanding expertise in these areas, with top-ranked Schools of Medicine, Environment, and Engineering; Departments of Statistical Sciences, Environmental Engineering, and Biology; and the Global Health Institute. Through integration of this transdisciplinary expertise, the Duke University Program in Environmental Health will provide pre- and postdoctoral trainees with essential research skillsets, guidance in professional development, and an inclusive and supportive training environment, thus producing deeply trained but interdisciplinary environmental health leaders who will contribute throughout their careers to solving society’s urgent environmental health needs.

PI_NAMEs: JONES, AKHENATON-ANDREW DHAFIR;MEYER, JOEL NEWMAN (contact);MURPHY, SUSAN KAY

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS (T)]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Estrogen;Genetics;Women's Health Research

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Endocrine therapy represents the most effective targeted therapy for estrogen receptor-positive breast cancers; however, their effectiveness is greatly limited by resistance development, toxicity and recurrence/relapse, posing a major clinical challenge. This proposal will lay the foundation for testing a new and nontoxic strategy for inhibiting tamoxifen resistant tumor growth and metastasis. In this proposal we will (1) elucidate the molecular underpinnings of a novel transcriptional reprogramming mechanism of tamoxifen resistance, (2) develop a nontoxic therapeutic strategy to overcome tamoxifen resistance, and (3) identify novel markers with diagnostic, prognostic, and/or targeted therapeutic potential.

PI_NAMEs: SHEKHAR, MALATHY PV (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: acquired drug resistance;Adjuvant;age group;Agonist;antagonist;Aromatase Inhibitors;beta catenin;Biology;biomarker identification;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Breast Cancer therapy;cancer cell;Cancer Etiology;Candidate Disease Gene;cell transformation;Cells;Chemopreventive Agent;ChIP-seq;Clinical;Clinical Management;Clinical Trials;Complex;CRISPR/Cas technology;Data;Development;Diagnostic;Effectiveness;Endocrine;Epigenetic Process;ESR1 gene;Estrogen receptor positive;Estrogen Receptors;Estrogen Therapy;Estrogens;Event;Feedback;Felis catus;Foundations;Gene Expression;Gene Targeting;Genes;genetic manipulation;Genetic Transcription;Growth Factor Receptors;hormone therapy;Human;Hyperactivity;in vivo evaluation;inhibitor;Knock-out;Link;Lysine;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Modeling;Molecular;Mus;Neoplasm Metastasis;neoplastic cell;Noltam;novel;novel marker;Oncogenic;Output;patient derived xenograft model;Patients;Polyubiquitination;Postmenopause;pre-clinical;Premenopause;preservation;prevent;Primary Neoplasm;prognostic;prognostic indicator;programs;promoter;Recurrence;Refractory;Rejuvenation;Relapse;Repression;Resistance;Resistance development;response;Response Elements;restoration;Role;Selective Estrogen Receptor Modulators;Signal Pathway;Signal Transduction;standard of care;stemness;Tamoxifen;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Toxic effect;transcription regulatory network;Transcriptional Activation;transcriptional reprogramming;transcriptome sequencing;tumor growth;UBE2B gene;Ubiquitin-Conjugating Enzymes;Ubiquitination;Up-Regulation;Variant;Woman;Women's mortality;Xenograft procedure

PROJECT_TITLE: Elucidation of a novel transcriptional reprogramming-induced mechanism of endocrine resistance and therapeutic targeting

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (J1)]