ADMINISTERING_IC: AG

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE (Public Health Relevance Statement) Alzheimer’s disease (AD) causes neuronal damage and loss over time, but underlying mechanisms remain unknown. The proposed research aims to close this knowledge gap by investigating how lipid pathways that control neuronal survival and repair are dysregulated in a transgenic rat model of AD, and by testing whether targeting defective lipid repair pathways in rats delays AD-related neuronal damage and loss. The proposed research will lay the scientific foundation for developing therapies that counteract neurodegeneration in AD by stimulating lipid-mediated brain repair pathways.

PI_NAMEs: TAHA, AMEER  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Acceleration;Address;Affect;Age;age related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid;Autopsy;Behavioral;behavioral impairment;Binding;Biological Availability;Brain;Brain Diseases;brain repair;Cholesterol Esters;Cognition;Cognitive;Cognitive deficits;Data;Dementia;Disease;Enzymes;Esterification;Etiology;Foundations;Goals;Human;human old age (65+);Impaired cognition;Impairment;improved;Individual;Inflammation;Infusion procedures;insight;Knowledge;Ligase;Lipase;lipid mediator;Lipids;Measures;Mediating;Mediator;Membrane;Nerve Degeneration;Neurofibrillary Tangles;neuroinflammation;neuron loss;neuronal survival;Neurons;neuroprotection;novel;Pathogenesis;Pathogenicity;Pathologic;Pathologic Processes;Pathway interactions;Persons;Phospholipids;Polyunsaturated Fatty Acids;public health relevance;Rat Transgene;Rattus;repaired;Research;Rodent;Rodent Model;Role;Senile Plaques;Source;Synapses;targeted treatment;tau Proteins;Testing;therapy development;Time;Tracer;Transferase;Transgenic Organisms;TRAP Complex;Triglycerides

PROJECT_TITLE: Identifying lipid mediator pathways involved in neuronal survival and repair in Alzheimer's disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: FD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE To address the FDA’s need for expanded regulatory science capabilities, the Research Triangle Center of Excellence in Regulatory Science and Innovation (Triangle CERSI) will provide a generative community for regulators, academia, and industry while serving as a one-stop-shop accelerator to meet current and evolving needs of regulatory science. The Triangle CERSI represents a collaboration of four leading academic institutions in North Carolina that are in close proximity (the University of North Carolina at Chapel Hill, Duke University, North Carolina State University, and North Carolina Central University). The Triangle CERSI aims to fully deploy our broad, collective expertise and close collaborations with FDA personnel to create and expedite utilization of important new knowledge in regulatory science and to provide an infrastructure of flexible and innovative toolsets to enrich the efficiency and value of FDA activities as part of the national CERSI program.

PI_NAMEs: HALABI, SUSAN ;MENTZ, ROBERT JOHN;SAMEI, EHSAN ;WATKINS, PAUL B (contact)

PROGRAM_OFFICER_NAME: CHEN, TRACY


PROJECT_TITLE: Research Triangle Center of Excellence in Regulatory Science and Innovation


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Epilepsy;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative The proposed research is relevant to public health because developing new quantitative methods to target and test epilepsy surgery in computer models before doing these procedures in the operating room will improve patient outcomes and reduce surgery side effects and costs. In this research we are also working with 15 major epilepsy centers to standardize treatment. For these reasons the proposal is relevant to part of the NIH’s mission to foster fundamental, creative discoveries and innovative research strategies that will ultimately protect and improve human health for the United States’ 3.3 million people with epilepsy.

PI_NAMEs: BASSETT, DANIELLE SMITH;LITT, BRIAN  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Ablation;Acceleration;Adoption;Algorithms;Anatomy;Archives;Biomedical Engineering;Brain Mapping;Brain region;Caring;Clinical;clinical care;clinical practice;clinical translation;Clinical Trials;Code;Collaborations;computational neuroscience;computer code;Computer Models;Computing Methodologies;cost;Creativeness;Data;Data Aggregation;data sharing;Diffuse;Eastern Cooperative Oncology Group;Electrodes;Electroencephalography;Engineering;Ensure;Epilepsy;Excision;Fostering;Foundations;Generations;Goals;Grant;Health;Human;Image;Implant;implantable device;improved;Individual;individual patient;Information Theory;innovation;Intervention;Letters;Machine Learning;Magnetic Resonance Imaging;Manuals;Maps;Measures;Metadata;Methods;Mission;Modeling;Morbidity - disease rate;Multi-Institutional Clinical Trial;network models;neuroimaging;Neurology;neuroregulation;Neurosciences;neurosurgery;novel;open source;Operating Rooms;Operative Surgical Procedures;Outcome;outcome prediction;Patient Care;Patient-Focused Outcomes;Patients;Pennsylvania;Persons;Pharmaceutical Preparations;Phase;Philosophy;Population;predictive tools;Probability;Procedures;prospective;Protocols documentation;Public Health;Quality of Care;Regional Anatomy;Research;Resected;Sampling;Sampling Biases;Sampling Errors;Seizures;side effect;Standardization;Structure;success;Testing;Tissues;Tonic-Clonic Epilepsy;tool;Translating;United States;United States National Institutes of Health;Universities;Validation;virtual;Work

PROJECT_TITLE: Guiding epilepsy surgery using network models and Stereo EEG


ACTIVITY: ZIA

ADMINISTERING_IC: AI

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Digestive Diseases;Genetics;Hematology;Infectious Diseases;Inflammatory Bowel Disease;Pediatric;Primary Immunodeficiencies;Rare Diseases;Sarcoidosis;Transplantation

PI_NAMEs: HOLLAND, STEVEN  (contact)

PROJECT_TERMS: Affect;African ancestry;Alleles;Aneurysm;Animals;Area;arterial tortuosity;autosome;B-Lymphocytes;Biochemical;Biological;Bone Marrow;Bone Marrow Transplantation;Cardiovascular system;Cells;chemokine;Chronic Granulomatous Disease;Clinical;Coccidioides;cohort;Collaborations;congenital immunodeficiency;Cyst;cytokine;Defect;Dental;Diagnosis;Disease;Distant;DOCK8 deficiency;dominant genetic mutation;Dominant-Negative Mutation;Endothelial Cells;Enzymes;Etiology;Evaluation;Extramural Activities;Functional disorder;gain of function;gastrointestinal;Generations;Genes;Genetic;Genotype;Genus staphylococcus;Goals;Hematopoietic;Histopathology;Histoplasma;Human;human model;Hyper-IgE Syndrome;Hypersensitivity;IgE;IL17 gene;Immune;immune function;immunopathology;Impaired wound healing;Impairment;In Vitro;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Innate Immune Response;intercellular communication;interest;Interferon Type II;Intestines;Investigation;Job's Syndrome;Laboratories;Link;loss of function;Lung;Lymphopenia;Malignant Neoplasms;Metabolism;microbiome research;minority health;Molecular;Molecular Genetics;mouse model;Mus;Muscle Cells;Mutation;Mycoses;Myelogenous;NADPH Oxidase;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural Immunity;Newly Diagnosed;Occupations;Operative Surgical Procedures;Organism;Osteopenia;Pathogenesis;Pathogenicity;Patients;Peroxides;Persons;Phagocytes;Phenotype;Portugal;Predisposition;Production;Productivity;programs;Protocols documentation;rac2 GTP-binding protein;Recurrence;recurrent infection;Reporting;Research Personnel;Resistance;Respiratory Tract Infections;Role;Sarcoidosis;Specimen;STAT1 gene;STAT3 gene;Superoxides;Syndrome;T-Lymphocyte;TNF gene;Transgenic Animals;Transplant-Related Disorder;Vascular Endothelial Cell;Work

PROJECT_TITLE: Transgenic Animal Models Of Human Immune Defects


NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Immunotherapy;Infectious Diseases;Lung;Rare Diseases;Sarcoidosis;Tuberculosis;Valley Fever

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adult;Affect;Bronchiectasis;Child;Coccidioidomycosis;Cryptococcosis;Cutaneous;Cystic Fibrosis;cytokine;Cytokine Receptors;Cytokine Signaling;cytokine therapy;Defect;Development;Diagnosis;Disease;Disease Resistance;Drug resistance;drug-sensitive;Dysmyelopoietic Syndromes;Epidemiology;Epigenetic Process;Epithelium;Etiology;experimental study;Functional disorder;fungus;gene product;Genes;Genetic;Genus Mycobacterium;Granulomatous;Granulomatous disease;Histoplasmosis;Host Defense;Human;IL17 gene;Immune;Immune response;Immunity;Immunobiology;Immunocompromised Host;Immunologic Adjuvants;In Vitro;Infection;Inflammatory;Innate Immune Response;interest;Interferon Type II;Interleukin-12;interleukin-23;Knowledge;Lesion;Lung;Lung Diseases;Lymphocyte;Macrophage;Malignant Neoplasms;Microbe;microbial;Microbiology;Mutation;mycobacterial;Mycobacterium Infections;Mycoses;Nature;non-tuberculosis mycobacteria;non-tuberculous mycobacterial infection;novel therapeutic intervention;Organism;Outcome;participant enrollment;pathogen;Pathogenesis;Pathway interactions;Patients;Phagocytes;Predisposition;Production;Regulation;response;Role;Salmonella;Sarcoidosis;Signal Pathway;Syndrome;Therapeutic;TNF gene;Tuberculosis;tuberculosis treatment

PROJECT_TITLE: Genes And Gene Products As Immunoadjuvants


NIH_SPENDING_CATS: Clinical Research;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adult;Antibodies;Asia;Autoantibodies;Biological Assay;Blood Banks;Chickenpox;Chronic Disease;cohort;Country;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus gattii;cytokine;Data;Defect;design;Diagnostic;Disease;disease natural history;East Asian;Enrollment;Epitopes;Far East;Granulocyte-Macrophage Colony-Stimulating Factor;Herpes zoster disease;Histoplasmosis;HIV;Human;Immune System Diseases;immunodeficiency;Immunologics;Infection;Interferon Type II;interleukin-23;International;Natural History;Nocardia Infections;non-tuberculosis mycobacteria;non-tuberculous mycobacterial infection;Opportunistic Infections;Patients;Pneumocystis;Proteome;Pulmonary Tuberculosis;Reporting;Research;rituximab;Salmonella infections;Sampling;screening;Site;Syndrome;Taiwan;Thailand;Thymoma;Tuberculosis;United States

PROJECT_TITLE: International Research in Thailand


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Immunotherapy;Infectious Diseases;Lung;Rare Diseases

PROJECT_TERMS: 18 year old;Affect;anti-CD20;Antibodies;Antigens;arm;Autoantibodies;Autoimmune Diseases;B-Lymphocyte Subsets;B-Lymphocytes;Blood;Bronchoscopy;Candidiasis;CD40 Ligand;Clinical;conventional therapy;cytokine;Disease;Endoscopy;Flow Cytometry;follow-up;Granulocyte-Macrophage Colony-Stimulating Factor;IL17 gene;Image;immunodeficiency;Immunologics;Infection;inflammatory marker;Infusion procedures;insight;Interferon Type II;Intravenous infusion procedures;Laboratories;Mediator;Methods;Monoclonal Antibody CD20;Mucocutaneous Candidiasis;Myasthenia Gravis;non-tuberculous mycobacterial infection;open label;participant enrollment;Pathogenicity;Patients;Pemphigus Vulgaris;phase I trial;Process;Production;Progressive Disease;Pulmonary Alveolar Proteinosis;Quality of life;Refractory;Rheumatoid Arthritis;rituximab;Safety;screening;Surveys;Syndrome;Toxic effect;Visit;X-Ray Computed Tomography

PROJECT_TITLE: Rituximab for Anticytokine Autoantibody-Associated Syndromes


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Microbiome;Pediatric;Primary Immunodeficiencies;Rare Diseases

PROJECT_TERMS: Adult;Affect;attenuation;Birth;carcinogenesis;cell type;Cells;Characteristics;Chronic;Chronic Granulomatous Disease;Clinical Protocols;Clinical Treatment;Colitis;Colon;Complex;congenital immunodeficiency;Defect;Disease;Disease susceptibility;early onset;Enzymes;epithelial repair;Epithelium;Family member;FPR1 gene;Gastrointestinal tract structure;Generations;Genetic Diseases;Goals;gut inflammation;gut microbiome;Health;Hematopoietic;Hematopoietic Stem Cell Transplantation;Homeostasis;Host Defense;Human;Immunologics;In Vitro;Infection;Inflammation;Inflammatory Response;interest;intestinal barrier;Intestines;Investigation;Lactobacillus;Large Intestine;Lead;Mediating;Methods;microbiome;microbiome research;microbiome signature;Modeling;mouse model;Mus;NADP;neutrophil cytosol factor 40K;neutrophil cytosol factor 67K;new therapeutic target;Oxidases;Pathogenesis;Pathologic;Patients;Pattern;Phagocytes;Physiological Processes;Predisposition;Production;Proteins;Reactive Oxygen Species;recurrent infection;Role;signal recognition particle receptor;Signaling Molecule;Single Nucleotide Polymorphism;Small Intestines;Source;Specimen;Surrogate Markers;Tissues;Translational Research;Treatment Protocols;Variant

PROJECT_TITLE: Role of reactive oxygen species and the microbiome in intestinal barrier homeostasis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: antibody test;Autoantibodies;Biological Assay;clinical center;Clinical Protocols;cohort;Country;COVID-19;COVID-19 patient;COVID-19 surveillance;cytokine;Disease Outcome;Employee;Enrollment;Goals;Individual;Infection;Interferon Type I;Italy;Longitudinal cohort study;Manuscripts;nasopharyngeal swab;neutralizing antibody;Patients;Polymerase Chain Reaction;prospective;Protocols documentation;Publishing;Reporting;Reverse Transcription;saliva sample;Sampling;SARS-CoV-2 exposure;SARS-CoV-2 infection;Science;screening;severe COVID-19;Severity of illness;Swab;Testing;United States National Institutes of Health

PROJECT_TITLE: Anticytokine Autoantibodies in COVID-19


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Orphan Drug;Patient Safety;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: UZEL, GULBU  (contact)

PROJECT_TERMS: arm;Biological Assay;Biological Markers;Clinical Protocols;Clinical Trials;Collaborations;congenital immunodeficiency;Defect;Disease;Dose;Genetic;Immune;immunoregulation;Institutional Review Boards;Link;Measures;multiple omics;open label;participant enrollment;Pathway interactions;patient population;Patients;Pharmacodynamics;Phosphatidylinositols;Phosphotransferases;PIK3CG gene;programs;response;Role;Safety;Signal Transduction;small molecule inhibitor;targeted treatment;treatment response

PROJECT_TITLE: Leniolisib for immunedysregulation


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

PI_NAMEs: BAUMANN, MICHAEL  (contact)

PROJECT_TERMS: abuse liability;Acute;Advocate;Agonist;analog;antagonist;Anxiety;ARRB2;Biological;Biological Assay;Brain;Buprenorphine;Carrier Proteins;cigarette smoking;Clinical Research;Cocaine;Cocaine use disorder;Cognition;Development;Dopamine;dopamine transporter;drug development;drug of abuse;drug seeking behavior;experimental study;extracellular;FDA approved;Fentanyl;Hallucinogens;Head;heroin use;HTR2A gene;Hybrids;Illicit Drugs;In Vitro;Ingestion;interest;Investigation;Journals;Laboratories;Ligands;Lisuride;Locomotion;Long-Term Effects;Lysergic Acid Diethylamide;male;Mediating;medication administration;Mental Depression;Mental disorders;Methamphetamine;monoamine;Mus;N,N-Dimethyltryptamine;natural hypothermia;Neurobiology;nicotine gum;novel;overdose death;Paper;Peer Review;Perception;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;pre-clinical;preclinical development;Property;Psilocybin;Publications;Publishing;Rattus;receptor;recruit;Reporting;Research;response;Rodent Model;Self Administration;Serotonin;Serotonin Receptor 5-HT1A;Serotonin Receptor 5-HT2A;serotonin transporter;Severities;Signal Transduction;Site;Stimulant;stimulant dependence;stimulant use;stimulant use disorder;Substance Use Disorder;synthetic opioid;Testing;Therapeutic Effect;Tryptamines;United States;Work

PROJECT_TITLE: Preclinical medication development for stimulant use disorder


NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Stimulant Use and Misuse;Substance Misuse

PROJECT_TERMS: abuse liability;addiction;Adverse effects;Affinity;analog;Animal Model;bath salts;behavioral study;Binding;Biological Assay;biological systems;Blood specimen;Body Temperature;Brain;Cannabinoids;Cells;Clinical;clinically relevant;Conscious;Data;Dopamine;driving force;Drug Kinetics;drug market;drug metabolism;drug of abuse;drug reward;Epidemic;experience;Exposure to;extracellular;Fentanyl;Goals;Human;Illicit Drugs;In Vitro;in vivo;interest;K2/Spice;Length;Life;manufacture;Membrane;Methods;Microdialysis;Molecular Mechanisms of Action;Morphine;Motor Activity;mu opioid receptors;Mus;nanomolar;Neurons;Opioid;Opioid agonist;opioid epidemic;opioid overdose;Overdose;Pathway interactions;Pharmaceutical Preparations;Pharmacology and Toxicology;Public Health;Publications;radioligand;Rattus;Recreation;Recreational Drugs;Research;Research Project Grants;research study;Risk;Self Administration;Serotonin;Structure-Activity Relationship;synthetic cannabinoid;synthetic drug;synthetic opioid;Transfection;Ventilatory Depression

PROJECT_TITLE: Pharmacology and toxicology of new psychoactive substances


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Depression;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: LUPICA, CARL  (contact)

PROJECT_TERMS: addiction;Affect;Aggressive behavior;Agonist;Amygdaloid structure;Anatomy;Animals;antagonist;Anxiety;Area;Association Learning;Behavior;Behavioral;Brain;Cells;Clinical;Cocaine;Cocaine Dependence;cocaine exposure;cocaine self-administration;Cocaine Users;Cocaine withdrawal;Cognitive;cognitive ability;Data;Decision Making;Dementia;differential expression;Disease;dorsal raphe nucleus;Drug Addiction;drug craving;Drug Utilization;Electrophysiology (science);Exhibits;experimental study;extracellular;Female;flexibility;Functional disorder;Glutamates;hippocampal pyramidal neuron;HTR2A gene;Human;Impairment;Impulsivity;Infusion procedures;inhibitory neuron;insight;Interneurons;Ketanserin;Learning;Lesion;Limbic System;Link;male;Medial Dorsal Nucleus;Mediating;Mental Depression;Mental disorders;Metabolic;Modality;Modeling;nerve supply;Neuromodulator;Neurons;neuropsychiatric disorder;neuropsychiatry;Neurotransmitters;novel;novel therapeutic intervention;Obsessive-Compulsive Disorder;Outcome;Output;Parvalbumins;Pharmaceutical Preparations;pharmacologic;Pharmacologic Actions;Pharmacology Study;Physiological;Play;Positioning Attribute;Post-Traumatic Stress Disorders;postsynaptic;presynaptic;Pyramidal Cells;raphe nuclei;Rattus;receptor;Receptor Activation;receptor function;reinforcer;Reporting;response;Reversal Learning;Rewards;Role;SB 242084;Sensory;sensory input;Serotonergic System;Serotonin;Serotonin Agents;serotonin receptor;Serotonin Receptor 5-HT2A;Serotonin Receptor 5-HT2C;sex;Signal Transduction;Slice;Smell Perception;Synapses;synaptic function;Synaptic Transmission;Taste Perception;Training;Ventral Striatum;Vision;Visual;Withdrawal

PROJECT_TITLE: Cocaine Addiction and the Role of Serotonin in Orbitofrontal Cortex Function


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: TANDA, GIANLUIGI  (contact)

PROJECT_TERMS: Absence of pain sensation;Acute;addiction;Affect;Affinity;Agonist;alcohol use disorder;analog;Attenuated;Autoreceptors;Behavioral;Behavioral Assay;Brain;Brain Diseases;Brain region;calmodulin-dependent protein kinase II;cell type;Cells;Chemical Structure;Clinical Research;Clinical Treatment;Clinical Trials;Cocaine;cocaine self-administration;Cocaine use disorder;Cocaine Users;comorbidity;Computer Models;Coupling;Crack Cocaine;Cre-LoxP;Data;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;dopamine D3 receptor;Dopamine Receptor;dopamine transporter;dopaminergic neuron;Dose;Drug Addiction;Drug Design;Drug Interactions;Drug Prescriptions;Drug Targeting;effective therapy;Electrochemistry;enantiomer;Environment;Exploratory Behavior;extracellular;FDA approved;Female;Future;Gender;Goals;Hyperactivity;Immunohistochemistry;In Situ Hybridization;inhibitor;Investigation;Knock-out;Locomotion;male;Measures;Mediating;Medical;Membrane;mesolimbic system;Metabolic Clearance Rate;Metabolic Pathway;Methamphetamine;Methamphetamine use disorder;Microdialysis;Midbrain structure;Modafinil;Molecular;Molecular Conformation;Mus;nanomolar;Nerve;neural circuit;Neurobiology;neurochemistry;Neurons;Neurotransmitters;novel;Nucleus Accumbens;Opioid;optogenetics;Oxycodone;oxycodone self-administration;Pathologic;Periodicity;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;Physiologic pulse;Physiological;Polymerase Chain Reaction;Population;postsynaptic;Pre-Clinical Model;preclinical study;predictive modeling;presynaptic;Presynaptic Receptors;Procedures;psychostimulant;Publications;receptor;receptor expression;receptor function;Research;response;reuptake;Rewards;Ritalin;Rodent;Role;Scanning;sex;Sex Differences;sigma receptors;Sleep Disorders;Sprague-Dawley Rats;stimulant use disorder;Substance Use Disorder;substance use treatment;Synapses;Synapsins;Synaptic Receptors;System;Techniques;Testing;Therapeutic;Time;Vesicle;virtual;Work

PROJECT_TITLE: Investigation On The Behavioral Effects And Related Neuro-Electrochemistry Of Potential Medications For The Treatment Of Substance Use Disorders.


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Cocaine;Complementary and Integrative Health;Drug Abuse (NIDA only);Endocannabinoid System Research;Mental Health;Natural Products;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: XI, ZHENG-XIONG  (contact)

PROJECT_TERMS: Affect;Affinity;Agonist;Amygdaloid structure;Anatomy;Animal Model;Animals;antagonist;Behavior;Behavioral Assay;Behavioral Model;Beta-caryophyllene;Binding;Biological Psychiatry;Brain;brain cell;Cannabinoids;Cannabis;Cells;CNR1 gene;CNR2 gene;Cocaine;Cocaine Dependence;cocaine use;Cognition;Collaborations;Decision Making;Dopamine;dopamine D3 receptor;dopaminergic neuron;Drug abuse;Drug Addiction;drug reward;experimental study;Feeling;gamma-Aminobutyric Acid;Glutamates;GPR55 receptor;heroin use;Human;Immune;Impulsivity;interest;International;Journals;Learning;Ligands;Magnetic Resonance Imaging;marijuana use;Midbrain structure;Molecular;Mus;National Institute of Drug Abuse;Natural Compound;Neurons;Neuropharmacology;neuropsychopharmacology;Nicotine;Nicotine Use Disorder;novel;Opiate Addiction;Opioid;Optics;optogenetics;Paper;Peripheral;Pharmaceutical Chemistry;Pharmaceutical Preparations;PPAR alpha;PPAR gamma;Psychiatry;Publishing;Reaction;receptor;Reporter;Research;Research Personnel;response;Rewards;rimonabant;Rodent;Role;Science;Self Stimulation;side effect;Substance Use Disorder;substance use treatment;Testing;Therapeutic;Training;Transgenic Mice

PROJECT_TITLE: Cannabinoid CB1 and CB2 receptors and drug abuse


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Cocaine;Drug Abuse (NIDA only);Endocannabinoid System Research;Mental Health;Neurosciences;Stimulant Use and Misuse;Substance Misuse

PROJECT_TERMS: Acetylcholine;Acute;Area;Attention deficit hyperactivity disorder;basal forebrain;Behavior;behavioral study;Bipolar Disorder;Brain;Brain Injuries;Brain region;Cannabis;CNR1 gene;Cocaine;cocaine seeking;drug abstinence;Drug usage;Drug Use Disorder;endogenous cannabinoid system;Food;Future;gamma-Aminobutyric Acid;Globus Pallidus;Glutamates;Goals;Habenula;Impulsive Behavior;Impulsivity;Ion Channel;Lateral;Learning;Light;Link;marijuana use;Mental disorders;Modeling;Muscarinic Acetylcholine Receptor;Neuroanatomy;Neurons;non-drug;Nucleus Accumbens;Obsessive-Compulsive Disorder;optogenetics;Pathway interactions;Pharmaceutical Preparations;Physiological;Plants;Play;prevent;Property;Psychological reinforcement;psychostimulant;Rattus;reinforced behavior;response;Role;Self Administration;Soldier;Source;Stimulus;synaptic inhibition;System;Tetrahydrocannabinol;Training;Traumatic Brain Injury;Ventral Tegmental Area;Viral;Work

PROJECT_TITLE: Role of the lateral habenula in impulsive behavior


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Contraception/Reproduction;Estrogen;Fibroid Tumors (Uterine);Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

PI_NAMEs: BAIRD, DONNA D. (contact)

PROJECT_TERMS: Address;African;African American Women;African ancestry;age related;aged;Animal Model;Area;Bacterial Vaginosis;Benign;Biometry;black women;Blood specimen;Body mass index;Boston;Cell Survival;Characteristics;Chemicals;Chlamydia;Clinic Visits;clinical diagnosis;cohort;Collaborations;Contraceptive Agents;Contraceptive Usage;Cytogenetics;Data;Data Collection;Data Files;Depo Provera;depressive symptoms;design;Development;Diagnosis;Diameter;DNA;Dysmenorrhea;Endocrine Disruptors;Enrollment;Environment;epidemiology study;Estrogens;Ethnic Population;European;Exclusion Criteria;Extramural Activities;feeding;Fertility;Fibroid Tumor;follow-up;Frequencies;Funding;Genistein;genital herpes;Genotype;Goals;Growth;Growth and Development function;Health;Herpesviridae Infections;high body mass index;Histologic;Hormonal;Hormonal Change;Hormones;Hypertension;Hysterectomy;Incidence;Incidence Study;Infant formula;Inflammatory;Injectable;interest;Investigation;Laboratories;Life;Life Style;Literature;Magnetic Resonance Imaging;Measurement;Measures;Medical Care Costs;Menstrual cycle;Methods;Michigan;Modeling;Monitor;Morbidity - disease rate;Mutation;National Institute of Child Health and Human Development;National Institute of Environmental Health Sciences;Normal Range;North Carolina;Operative Surgical Procedures;Outcome;Ovarian aging;ovarian reserve;Participant;personal care products;Phytoestrogens;Polycystic Ovary Syndrome;Postmenopause;Pregnancy Outcome;Progesterone;Progestins;prospective;Prospective Studies;Psychosocial Factor;Puberty;Reporting;reproductive tract;Reproductive Tract Infections;Research;research study;Resources;Risk;Risk Factors;risk variant;Sampling;Sampling Studies;Serology;Serum;side effect;Sleep;sleep health;Smooth Muscle Tumor;Somatic Mutation;soy;Statistical Data Interpretation;Study models;Suggestion;Supplementation;survivorship;Swab;Symptoms;Testing;Time;Tissues;tumor;Tumor Tissue;tumorigenesis;ultrasound;United States;Universities;Urine;Uterine Fibroids;Vagina;Visit;Vitamin D;Vitamin D Deficiency;White Women;Whole Blood;Woman

PROJECT_TITLE: Uterine Leiomyomas


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Dementia;Depression;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Lung;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Serious Mental Illness;Sleep Research

ORG_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

PI_NAMEs: LI, LEPING  (contact)

PROJECT_TERMS: Adult;Affect;Age;Alpha Rhythm;Alzheimer's Disease;Apnea;Area;autism spectrum disorder;Bioinformatics;Brain;Brain region;Breathing;Cardiovascular system;Characteristics;Chromosome 21;Chronic;circadian;Classification;clinical diagnosis;Clinical Trials;cognitive function;Congenital chromosomal disease;Data;Delta Rhythm;Depressed mood;Depressive disorder;Diabetes Mellitus;Diagnosis;Disease;Down's Syndrome;Drowsiness;Early Diagnosis;Early Onset Alzheimer Disease;Early treatment;Eating;Electroencephalography;Electrophysiology (science);Etiology;Event;Exhibits;experience;Eye;Frequencies;Genetic;Genetic Diseases;Glucose;Goals;Health;Health Benefit;Heart Rate;Height;High Prevalence;Hour;Human;Hypertension;Impaired cognition;improved;indexing;Intellectual functioning disability;interest;Interruption;Laboratories;Machine Learning;machine learning algorithm;machine learning method;Major Depressive Disorder;male;Measures;men;Mental disorders;Methodology;Modeling;Monitor;National Institute of Mental Health;Nervous System Disorder;non rapid eye movement;Obesity;Obstructive Sleep Apnea;Oxygen;Parkinson Disease;patient response;Patients;Performance;Peripheral;Persons;Physiologic pulse;pleasure;Polysomnography;Population Study;predictive tools;Prevalence;Public Health;Quality of life;REM Sleep;Research;respiratory;Rest;Risk;screening;Seizures;Severities;sex;Signal Transduction;single episode major depressive disorder;Sleep;Sleep Apnea Syndromes;Sleep Disorders;sleep spindle;Sleep Stages;Specificity;statistical and machine learning;Surrogate Markers;Testing;Time;Time trend;tool;Training;trend;United States;user-friendly;Validation;web site;Weight;Weight Gain;Woman;Work

PROJECT_TITLE: Bioinformatics


NIH_SPENDING_CATS: Asthma;Lung

PI_NAMEs: COOK, DONALD N (contact)

PROJECT_TERMS: Adjuvant;Affect;Airway Disease;airway epithelium;airway hyperresponsiveness;Allergens;Allergic;Allergic inflammation;Animals;Antigens;Asthma;asthma model;Cell Differentiation process;Cell Line;Cell Physiology;Cell surface;cell type;Cells;cytokine;Cytometry;Dendritic cell activation;Dendritic Cells;draining lymph node;Environment;environmental agent;Eosinophilia;Epithelial Cells;Epithelium;Experimental Designs;Extrinsic asthma;Flagellin;Flow Cytometry;gene product;Genes;Goals;IL17 gene;Immune response;improved;Individual;Inhalation;interest;Interleukin-13;ITGAM gene;Laboratories;Ligands;Lipopolysaccharides;Lung;Lung Diseases;Mediating;migration;Molecular;mouse model;Mus;Mutation;Neutrophilia;novel;Ovalbumin;Pathway interactions;Peptide Hydrolases;Peptides;Population;prevent;Quality of life;Regulation;response;Role;Signal Transduction;single-cell RNA sequencing;stem;T-Lymphocyte;Testing;Thoracic Lymph Node;tissue resident memory T cell;TNF gene;Toll-like receptors

PROJECT_TITLE: Allergic sensitization through the airway


NIH_SPENDING_CATS: Aging;Cancer;Digestive Diseases;Genetics;Microbiome;Nutrition;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: LI, XIAOLING  (contact)

PROJECT_TERMS: Acute;acyl group;Acylation;age acceleration;age related;age-related disease;Aging;aging related;amidation;Anabolism;Animals;anti-microbial peptide;Area;Biochemical Reaction;biological adaptation to stress;Biological Models;Biology;cancer cell;cancer type;Cell Death;cell growth regulation;Cell Physiology;Cells;Cellular Metabolic Process;chemically induced colitis;Chemicals;clinical investigation;cofactor;Colitis;Consumption;Coupled;Cultured Cells;Deacetylase;deamidation;Development;Diet;dietary;Disease;DNA Repair;Electrons;Endocrinology;endoplasmic reticulum stress;Energy Metabolism;Environment;Environmental Risk Factor;environmental stressor;Enzymes;epigenetic regulation;Epithelial Cells;Equilibrium;Family;fecal transplantation;gastrointestinal;gastrointestinal epithelium;gene environment interaction;Genes;Genetic;genetic approach;Genetic Transcription;Genome Stability;Goals;Growth;gut inflammation;gut microbiota;Histones;Homeostasis;host-microbe interactions;Human;human disease;Immune;Impairment;improved;Inflammation;Inflammatory;Intestinal Diseases;Intestines;intraepithelial;Journals;Life Style;Link;Lysine;Maintenance;Malignant Neoplasms;Mediating;member;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;Microbe;microbiome;microbiota;Molecular;Monitor;Mus;Neurodegenerative Disorders;Niacinamide;Nicotinamide adenine dinucleotide;Nicotinic Acids;novel strategies;Nuclear;Nuclear Receptors;Nutrient;old mice;Paneth Cells;Paper;Pathogenesis;Pathologic;Pathway interactions;Physiological;Physiology;Play;Poly(ADP-ribose) Polymerases;Post-Translational Protein Processing;Prevention;Process;Production;Prognosis;Protein Acetylation;Proteins;Publishing;Regulation;Reporting;Research;Resistance;response;RNA Splicing;Role;sensor;Signal Transduction;SIRT1 gene;Sirtuins;Site;stem cell niche;stem cells;Stress;stressor;tissue stress;Tissues;transcription factor;Transcription Repressor;Transferase;trend;tumor;Tumor Promotion;tumorigenesis;WNT Signaling Pathway

PROJECT_TITLE: Sirtuins and nuclear receptors in aging and age-associated diseases


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Complementary and Integrative Health;Contraception/Reproduction;Dietary Supplements;Diethylstilbestrol (DES);Endocrine Disruptors;Estrogen;Genetics;Human Genome;Infertility;Natural Products;Pediatric;Uterine Cancer;Women's Health Research

PI_NAMEs: WILLIAMS, CARMEN  (contact)

PROJECT_TERMS: Adolescent;Adult;Affect;Age;Biological Models;Biology;Birth;Cell Differentiation process;Chemical Exposure;Chromatin;Development;Diethylstilbestrol;DNA Methylation;Dose;Enhancers;Environment;environmental chemical;environmental chemical exposure;Epigenetic Process;Epithelial Cells;estrogenic;Estrous Cycle;Female;female reproductive tract;Fertility;Fertilization;Functional disorder;Genes;genetic approach;Genistein;genome-wide;Germ Cells;Goals;Human;Infant formula;Infertility;Knowledge;Long-Term Effects;male;malformation;Malignant Neoplasms;Measures;Mediating;mouse model;Mus;Neonatal;older adult;Organism;Pattern;Phase;Physiological;Phytoestrogens;postnatal;Pre-implantation Embryo Development;preimplantation;prenatal;Process;Publications;Publishing;Reproduction;reproductive;Reproductive Medicine;reproductive tract;Research;single-cell RNA sequencing;Site;soy;Time;transcription factor;Uterine Cancer;Uterus;Work

PROJECT_TITLE: Environmental influence on reproductive tract function


PI_NAMEs: GARANTZIOTIS, STAVROS  (contact)

PROJECT_TERMS: Affect;airway hyperresponsiveness;angiogenesis;Area;asthma model;Binding;CD44 gene;Cell Communication;Clinical Research;Complement;Environmental Exposure;epithelial wound;Extracellular Matrix;Extravasation;fibrotic lung;Gases;Goals;Grant;healing;Human;Hyaluronan;Immunologic Receptors;Inhalation;Injury;inter-alpha-inhibitor;interstitial;Legal patent;Lung;lung injury;Mediation;Modality;Molecular Weight;mouse model;neovascularization;novel;ozone exposure;Participant;Patients;Production;Pulmonary Fibrosis;Pulmonary Inflammation;receptor;Receptor Cell;Research;response;Role;Serum;Serum Proteins;Stimulus;Tenascin;Therapeutic;Therapeutic Uses;tissue injury;Tissues;TLR4 gene;TLR5 gene;Touch sensation;Vitronectin;wound healing

PROJECT_TITLE: The Role of Hyaluronan And Inter-Alpha-Trypsin Inhibitor in Tissue Injury


NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human

PI_NAMEs: JOTHI, RAJA  (contact)

PROJECT_TERMS: Aberrant DNA Methylation;Adult;Affect;Architecture;Behavior;Binding;Biochemical;Biochemistry;Biological Process;C-terminal;cancer cell;Cell Differentiation process;Cell Fate Control;Cell Physiology;Cells;cellular development;Chromatin;chromatin remodeling;Complex;Cues;Data;Development;Developmental Gene;diagnostic development;Disease;DNA;DNA Methylation;Embryonic Development;embryonic stem cell;Environment;environmental change;Enzymes;Epiblast;Epigenetic Process;epigenome;epigenomics;exportin 1 protein;Exportins;Foundations;functional genomics;Gene Expression;Gene Expression Regulation;gene network;gene regulatory network;gene repression;Genes;Genetic study;Genetic Transcription;Genome;genome-wide;Genomics;Goals;Health;histone modification;Homeostasis;Hydrophobicity;Hypermethylation;implantation;improved;interdisciplinary approach;interest;Knowledge;Laboratories;Malignant Neoplasms;Manuscripts;MAP Kinase Gene;Maps;Mediating;Modeling;Modification;Mouse Embryonic Stem Cells;Nuclear Export;Outcome;Phenotype;Polycomb;Predisposition;Preparation;programs;promoter;Protein Export Pathway;Publishing;receptor;recruit;Regulation;Regulatory Element;Repression;Research;response;Role;self-renewal;Signal Transduction;Site;stem cells;Stimulant;System;Systems Biology;Tail;Testing;Therapeutic;transcription factor

PROJECT_TITLE: Gene regulatory elements, networks, and mechanisms


PI_NAMEs: RESNIK, DAVID  (contact)

PROJECT_TERMS: Animals;Authorship;Collaborations;Collection;commercialization;Conflict of Interest;Data;data management;Environmental Health;Environmental Risk Factor;ethical, legal, and social implication;Ethics;Focus Groups;Goals;Human;human subject;Human Subject Research;Informed Consent;Intellectual Property;International;Interview;Laws;Legal;Peer Review;Philosophy;Publications;Regulation;Research;Research Ethics;Research Methodology;Research Misconduct;Research Project Grants;Review Literature;Risk;Risk Management;Social Responsibility;Surveys

PROJECT_TITLE: Ethical, social, and legal issues in environmental health research


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences

PI_NAMEs: JENSEN, PATRICIA  (contact)

PROJECT_TERMS: Address;Adult;Area;Attention;Behavioral;Brain;Brain Stem;Cells;Central Nervous System;Cognition Disorders;critical period;Desire for food;Development;developmental neurobiology;Disease;Emotions;Exposure to;Functional disorder;Genetic;genetic approach;Goals;innovation;insight;Investigation;Life;Long-Term Effects;Memory;Molecular;Mood Disorders;mouse model;Mus;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuron development;Neurons;noradrenergic;Norepinephrine;Optics;Phenotype;Population Heterogeneity;Predisposition;response;Signal Transduction;Stress;Structure;System;Viral;virtual

PROJECT_TITLE: Central Noradrenergic Neuron Subtype Development and Function


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Congenital Structural Anomalies;Endocrine Disruptors;Estrogen;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Pediatric;Prevention;Social Determinants of Health;Urologic Diseases;Women's Health Research

PI_NAMEs: YAO, HUMPHREY  (contact)

PROJECT_TERMS: Address;Adult;Affect;Anatomy;Animal Model;Atlases;Bisexual;Cell Communication;Cell Lineage;Cell Nucleus;cell type;Cells;Chromatin;climate change;cohort;Congenital Abnormality;congenital anomaly;Cues;Data;Decision Making;Development;Developmental Biology;Disease;EGF gene;Embryo;Embryology;Embryonic Development;Endocrine Disruptors;Environment;Environmental Risk Factor;estrogenic;Estrogens;Exhibits;Exposure to;external genitalia;Family;Female;Female genitalia;Female urethral structure;Fertility;fetal;Foundations;Gene Expression;Gene Expression Profile;gene network;gene regulatory network;Genes;Genetic;Genitalia;Germ Cells;Goals;Gonadal structure;health of the mother;Heat Stress;High Risk Woman;High temperature of physical object;Hindgut;Histology;Human;Hypospadias;Image;Incidence;Infection;Infertility;interest;Joints;Kidney Diseases;Knowledge;Life;Link;male;Maps;Mesenchymal;Modeling;Molecular;Molecular Profiling;multimodality;multiple omics;Mus;neonatal mice;Neuregulins;Newborn Infant;novel;Nuclear Orphan Receptor;offspring;Ontology;Organ;organ growth;Outcomes Research;paracrine;Pathway interactions;Pattern;Population;population migration;postnatal;Predisposition;Pregnancy;Pregnant Women;prenatal exposure;Process;Quality of life;Recurrence;Regulatory Element;Reporting;reproductive;reproductive organ;reproductive outcome;Reproductive Process;reproductive tract;Research;response;RNA;sex;sex determination;sexual dimorphism;Sexual Reproduction;Signal Transduction;single nucleus RNA-sequencing;Somatic Cell;Source;Specific qualifier value;Spermatocytes;stem cells;steroid hormone;Steroids;Structure of primordial sex cell;Supporting Cell;timeline;Tissues;transcription factor;transcriptome;transcriptome sequencing;Urethra;urogenital tract;Work;XCL1 gene

PROJECT_TITLE: Impacts of Genetic and Environmental Factors on Reproductive Organ Development


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Infertility;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PROJECT_TERMS: Affect;assisted reproduction;Behavior;Biology;blastocyst;Calcium;Calcium Oscillations;Calcium Signaling;Cell membrane;Development;Disease;Divalent Cations;egg;Embryo;embryo culture;Embryonic Development;Environment;environmental chemical;Environmental Risk Factor;Epigenetic Process;Event;Exposure to;Female;Fertility;Fertilization;Genetic Processes;Genetic Transcription;Genome;Germ Cells;Goals;Health;Hour;Human;human disease;Infertility;Knowledge;Learning;Magnesium;male;Mammals;Maternal Messenger RNA;Mediator;Membrane Fusion;Molecular;mouse model;Mus;offspring;oocyte maturation;Pattern;Phase;Phospholipase C;pluripotency;PMCA1 protein;Pre-implantation Embryo Development;preimplantation;Procedures;Process;programs;Publishing;recruit;Regulation;release of sequestered calcium ion into cytoplasm;Reproduction;Reproductive Medicine;Research;response;Role;Series;Signal Transduction Pathway;sperm cell;Sperm Head;Testis;Totipotency;transcription factor;Translations;Work

PROJECT_TITLE: Environmental influence on gametes and embryos


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Prevention;Women's Health Research

PI_NAMEs: ZHAO, SHANSHAN  (contact)

PROJECT_TERMS: Acceleration;Algorithms;Area;Biological Assay;Biology;biomarker selection;Birth;Breast Cancer Risk Factor;Clinical;cohort;Data;Data Analyses;design;detection limit;Diagnostic;disorder risk;epidemiology study;Failure;Goals;Health;high risk population;interest;Joints;Linear Models;Mediation;Methodology;Methods;Modeling;Outcome;Oxidative Stress;Pathway interactions;Performance;Pregnant Women;Procedures;prognostic;Research;Risk Assessment;Risk Factors;risk prediction;Selection for Treatments;semiparametric;Sister;Statistical Methods;survival outcome;Time;tool;Trace metal;urinary

PROJECT_TITLE: Statistical Methods in Disease Risk Assessment and Prediction


PROJECT_TITLE: Application of Statistical Methods in Epidemiology Studies


NIH_SPENDING_CATS: Biomedical Imaging;Childhood Obesity;Clinical Research;Contraception/Reproduction;Estrogen;Nutrition;Obesity;Pediatric;Women's Health Research

PI_NAMEs: SHAW, NATALIE  (contact)

PROJECT_TERMS: Adipose tissue;Adult;Age;Androgens;Automobile Driving;Bile Acids;Blood;Body fat;Body Weight;bone age;Breast;Childhood;Clinical Research;Collection;Data;Development;Dryness;Dual-Energy X-Ray Absorptiometry;Endometrial;Enrollment;Entire hair of pubis;Epithelial Cells;Estradiol;Estrogens;Estrone;Genitourinary system;girls;Gonadal Steroid Hormones;Hand;Height;Hormones;indexing;inhibin B;Mammary Gland Parenchyma;Mammary Ultrasonography;Measures;Menarche;Menstrual cycle;Methods;Monitor;Morphology;National Institute of Environmental Health Sciences;Obesity;Obesity Epidemic;Organ;Ovarian;Overweight;Pelvis;Peripheral;Phenotype;Physiological;Population;Pregnanediol;Procedures;Protocols documentation;Puberty;Reporting;reproductive axis;reproductive hormone;Roentgen Rays;Serum;Source;Staging;Testing;Thick;Time;Tissues;trend;Ultrasonography;ultrasound;urinary;Urine;Uterus;Vagina;Visit;Waist-Hip Ratio;Weight

PROJECT_TITLE: Investigating the impact of obesity on pubertal development in girls


PI_NAMEs: HALL, JANET  (contact)

PROJECT_TERMS: Anosmia;Development;Diagnosis;Disease;Estradiol;Failure;Female;Fertility;Functional disorder;General Hospitals;Genetic;Genotype;Gonadotropin Hormone Releasing Hormone;Gonadotropins;hormone deficiency;Hospitals;Hypothalamic structure;Idiopathic Hypogonadotropic Hypogonadism;Incidence;Inherited;Kallmann Syndrome;Klinefelter's Syndrome;male;Massachusetts;men;Molecular;Neurosecretory Systems;Patients;Phenotype;Physiological;Pituitary Gland;Protocols documentation;Puberty;Rare Diseases;Regimen;Regulation;Reproduction;reproductive function;reproductive system disorder;Research Personnel;Role;Smell Perception;Testosterone;Woman

PROJECT_TITLE: Studies in Patients with Congenital GnRH Deficiency


PROJECT_TERMS: Age;Amenorrhea;androgen excess;Bioinformatics;Body Weight;Body Weight Changes;Characteristics;Clinical;Clinical Endocrinology;clinical heterogeneity;Clomiphene Citrate;Collaborations;Computer software;Constitution;Control Groups;Data;Delayed Puberty;Development;Discrimination;Disease;Eating Disorders;Endocrine;Endocrinology;Environmental Risk Factor;epidemiology study;Equilibrium;Estrogens;Exercise;exome sequencing;feeding;Female;Fertility;Functional disorder;functional hypothalamic amenorrhea;Genes;Genetic Determinism;Genetic Diseases;Genetic Predisposition to Disease;girls;GNRH1 gene;Height;Hemorrhage;Heterozygote;Hyperprolactinemia;Hypogonadism;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;improved;Individual;individual response;insight;inter-individual variation;Journals;Manuscripts;Menstruation;Metabolic;Metabolic stress;Methodology;Modeling;Mutation;National Human Genome Research Institute;nonhuman primate;Nutritional;Oligonucleotides;Pathway interactions;Patients;Pattern;Peripheral;Phenotype;phenotypic data;physiologic stressor;Polycystic Ovary Syndrome;Population;Predisposition;Pregnancy;Prevalence;Progestins;programs;psychologic;Psychological Stress;public database;Publications;Publishing;Quality Control;Questionnaires;Rare Diseases;rare variant;Recontacts;Recording of previous events;reproductive;reproductive axis;Reproductive system;Research;Research Personnel;response;Risk;Risk Factors;Role;Running;Sample Size;Satiation;screening;Signal Transduction;Signs and Symptoms;Statistical Methods;Stress;Testing;Thyroid Gland;Time;Update;Variant;Weight;Withdrawal;Woman;women's outcomes

PROJECT_TITLE: Genetic Determinants of Hypothalamic Amenorrhea


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Infertility;Neurosciences;Nutrition;Physical Activity;Prevention;Women's Health Research

PROJECT_TERMS: Acute;adipokines;adiponectin;Adipose tissue;Affect;Age;Algorithms;Amenorrhea;Anovulation;Attitude;Biochemical Markers;Biological Markers;Body Composition;Body mass index;Body Weight decreased;Breast Feeding;Caloric Restriction;Cerebrospinal Fluid;Characteristics;Chronic;Clinical;Clinical Markers;college;Conjugated Estrogens;Controlled Study;Cross-Sectional Studies;Delayed Puberty;deprivation;Desire for food;dietary;Dose;energy balance;Energy Intake;Energy Metabolism;Environment;environmental stressor;Equilibrium;Etiology;Evaluation;Exercise;Exposure to;Family;Family history of;Fasting;fitness;Follow-Up Studies;Frequencies;Functional disorder;ghrelin;Glucose;GNRH1 gene;Goals;Gonadotropins;Height;Homeostasis;hormonal signals;Hormone secretion;Hydrocortisone;Hypothalamic structure;improved;Individual;Infertility;Insulin;Intake;Intervention;Intervention Studies;Interview;Laboratories;lean body mass;Length;Leptin;Life Style;Link;Longterm Follow-up;Luteal Phase;Manuscripts;Measures;Mediating;Medical History;men;Menarche;Menstrual cycle;Metabolic;Metabolic hormone;Metabolism;Mutation;Neurons;Neurosecretory Systems;nutrition;Nutritional;Outcome Measure;Ovulation;Oxygen Consumption;Parents;Pathway interactions;Patients;peptide hormone;Physiologic pulse;physiologic stressor;Pituitary Gland;Plasma;Play;Predictive Factor;Predisposition;Pregnancy;Pregnanediol;primary outcome;proliferative phase Menstrual cycle;Questionnaires;receptor;Recording of previous events;Regulation;Reproduction;reproductive;reproductive axis;reproductive function;Reproductive History;response;Rest;restrictive eating;Risk;Role;Sampling;Satiation;secondary outcome;Serum;Signal Transduction;Sleep;Somatotropin;Stomach;Stress;stressor;System;Thyroid Function Tests;Thyroid Hormones;Urine;Visit;VO2max;Woman;Women's study;young woman

PROJECT_TITLE: Caloric Restriction, Environment, and Fitness: Reproductive Effects Evaluation Study (CaREFREE Study)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cancer;Cardiovascular;Childhood Obesity;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: JACKSON, CHANDRA  (contact)

PROJECT_TERMS: actigraphy;Address;Adult;adverse childhood events;Affect;African American;African American Women;Age;age effect;age related changes;age related decline;aged;Aging;Air Pollution;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Athletic;Baltimore;Behavior;Biological;Black American;Black Populations;Black race;black women;Breast;Cancer Survivor;cardiometabolism;Cardiovascular Diseases;cardiovascular health;Censuses;Characteristics;Child;Childhood;circadian;Circadian Rhythms;Clinical;Cognitive;cohort;Cohort Studies;Collaborations;college;comorbidity;Complex;Country;Data;Diabetes Mellitus;Diagnosis;Disadvantaged;Discrimination;disease registry;Disparity;Education;Enrollment;Environment;Environmental Epidemiology;Environmental Hazards;Environmental Impact;Environmental Risk Factor;ethnic discrimination;ethnic disparity;ethnic minority population;Ethnic Origin;experience;Exposure to;Fibroid Tumor;food insecurity;food security;Functional disorder;Health;health determinants;health disparity;health equity;health equity promotion;Health Food;health inequalities;high risk;Hispanic;Homeostasis;Housing;Human;Hypertension;improved;improved outcome;Individual;Inequity;Intervention;Jet Lag Syndrome;killings;Latinx;Life Cycle Stages;Life Style;lifestyle factors;Light;Lighting;Link;longitudinal analysis;Longitudinal Studies;Malignant Neoplasms;marijuana use;men;Modeling;National Health Interview Survey;Native Hawaiian;neighborhood disadvantage;Neighborhoods;Noise;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;Obesity;obesity risk;Occupational;Occupations;Outcome;Pacific Islander;Pattern;Performance;Personal Satisfaction;Persons;Physical environment;Physiological;Play;Policies;poor health outcome;poor sleep;Population;Poverty;Prevalence;prevent;professional atmosphere;Protocols documentation;Psychosocial Stress;Public Health;Race;racial determinant;racial difference;racial discrimination;racial disparity;racial minority population;Recommendation;Recording of previous events;Research;response;Risk;Role;rural area;Schedule;Services;sex;Sister;Skin Carcinoma;Sleep;Sleep Deprivation;Sleep disturbances;sleep health;sleep quality;Sleeplessness;social;Social Environment;social health determinants;socioeconomic disparity;Socioeconomic Status;South Carolina;Special Population;Specialist;student athlete;substance use;Surveys;Survivors;symposium;Symptoms;Temperature;Travel;Woman;young adult

PROJECT_TITLE: Social and Environmental Determinants of Health Equity


NIH_SPENDING_CATS: Clinical Research;Facioscapulohumeral Muscular Dystrophy;Genetics;Muscular Dystrophy;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Arhinia choanal atresia microphthalmia;clinical center;cohort;Collaborations;craniofacial;Defect;Exons;experimental study;Facioscapulohumeral Muscular Dystrophy;Family member;Fibroblasts;genetic architecture;Genotype;Goals;Heterozygote;in vitro Model;induced pluripotent stem cell;International;Investigation;Missense Mutation;Molecular;Muscular Dystrophies;neuromuscular;Patient Recruitments;patient subsets;Patients;Phenotype;Punch Biopsy;reproductive;Skin;structural biology;United States National Institutes of Health;X-Ray Crystallography

PROJECT_TITLE: Investigation of the genetic architecture and phenotypic spectrum of Bosma arhinia microphthalmia syndrome


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Endocrine Disruptors;Estrogen;Genetics;Women's Health Research

PI_NAMEs: RODRIGUEZ, JOSEPH  (contact)

PROJECT_TERMS: Acute;antagonist;Binding;Biochemical Process;Biological Assay;Breast Cancer Cell;breast cancer diagnosis;Cancer cell line;Cell Differentiation process;Cell Proliferation;Cells;Characteristics;Chemicals;Chromatin;chromatin remodeling;Chromosomes;cofactor;Complex;Data;Disease;Distal;Dose;effective therapy;Endocrine Disruptors;Enhancers;Environment;Environmental Exposure;Epigenetic Process;ESR1 gene;Estradiol;Estrogen receptor positive;Estrogen Receptors;Estrogen Therapy;Estrogens;Exhibits;Exposure to;Food;Gene Expression;Gene Expression Regulation;gene product;gene repression;Genes;Genetic;Genetic Transcription;genome-wide;genomic locus;Goals;Grouping;Heterogeneity;Hormone Responsive;Hormones;Imaging technology;Individual;Inflammation;interest;knock-down;Light;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;Mediating;Memory;Modeling;Molecular;Mus;Mutation;Nature;Neoplasm Metastasis;non-genetic;Normal tissue morphology;Nuclear Receptors;Organism;permissiveness;Phenotype;Population;Process;progenitor;promoter;Reagent;receptor expression;recruit;Regulation;Repression;Resistance;response;RNA;RNA chemical synthesis;Signal Pathway;Signal Transduction;single molecule;stem cells;Steroids;Stimulus;Stress;System;Tamoxifen;Temperature;Therapeutic;Time;Tissues;transcription factor;Transcription Initiation;Transcription Process;tumor;Visualization;Vitamins;Work;Xenobiotics

PROJECT_TITLE: Environmental regulation of estrogen responsive genes in single living cells


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Ovarian Cancer;Prevention;Rare Diseases;Social Determinants of Health;Uterine Cancer;Women's Health Research

PI_NAMEs: WHITE, ALEXANDRA  (contact)

PROJECT_TERMS: Air Pollutants;Air Pollution;Area;Biological;Biological Markers;black women;blood-based biomarker;Breast;Breast Cancer Risk Factor;cancer diagnosis;cancer epidemiology;cancer risk;carcinogenesis;Characteristics;Chemical Exposure;Clinical Markers;cohort;Cohort Studies;combustion product;criteria air pollutant;Data;deprivation;Development;DNA Methylation;Enrollment;Environment;environment related cancer;environmental chemical;Environmental Exposure;Environmental Health;Environmental Risk Factor;epigenetic aging;epigenetic marker;Exposure to;fine particles;Geography;Goals;Hair;Health;high risk;High Risk Woman;improved;Incidence;Individual;Industrialization;interest;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammary Gland Parenchyma;Measures;Meta-Analysis;Metals;modifiable risk;Nature;Nitrogen Dioxide;Not Hispanic or Latino;Ovarian;Pathway interactions;personal care products;pollutant;Pollution;Poly-fluoroalkyl substances;Population;Population Study;prospective;Prospective cohort;Prospective Studies;Questionnaires;Radiation;Research;Research Design;Risk;Risk Factors;Role;Sister;Site;Source;Specimen;Structure of nail of toe;study population;Surrogate Endpoint;systematic review;United States;United States National Institutes of Health;Uterine Cancer;Uterus;White Women;Woman;women's diagnosis;Women's study;Work

PROJECT_TITLE: Environment and Cancer Epidemiology


NIH_SPENDING_CATS: Aging;Clinical Research;Complementary and Integrative Health;Contraception/Reproduction;Dietary Supplements;Infertility;Nutrition;Pregnancy;Prevention;Women's Health Research

PI_NAMEs: JUKIC, ANNE MARIE  (contact)

PROJECT_TERMS: 25-hydroxyvitamin D;Age;Age at Menarche;Air Pollution;Animal Model;bone health;calcium absorption;Child;Chronic;Climate;clinical biomarkers;Clinical Trials;cohort;Communities;Conceptions;Development;dietary supplements;digital;digital health;early pregnancy;Emotional;Endocrine;Epigenetic Process;Event;extracellular vesicles;Female;Fertility;First Pregnancy Trimester;Food Supplements;Goals;health application;Hormones;Human;implantation;improved;Inflammation;interest;Irregular Menstruation;Length;Life Cycle Stages;Liver;Malignant Breast Neoplasm;Measures;Menopause;Menstrual cycle;MicroRNAs;mullerian-inhibiting hormone;Natural History;Ovarian aging;ovarian reserve;Ovulation;ovulation time;Participant;Pattern;Placentation;pregnancy health;Pregnancy loss;Pregnancy Outcome;Probability;public health relevance;Publishing;Reporting;Reproduction;reproductive function;Reproductive Health;Reproductive History;reproductive senescence;Research;response;Role;Sampling;Seasons;Signal Transduction;Skin;subfertility;Sunlight;symposium;systematic review;Testing;Time;Ultraviolet Rays;Vitamin D;Vitamin D Deficiency;Vitamin D supplementation;Vitamins;Woman;Women's Health

PROJECT_TITLE: Environmental influences on fertility and reproductive health


PI_NAMEs: MORGAN, MARCOS  (contact)

PROJECT_TERMS: Affect;Animal Model;Cells;Complex;Couples;detection method;Environmental Risk Factor;Enzymes;Equilibrium;Etiology;Female;Gametogenesis;Generations;Genetic;Genetic study;Germ Lines;Goals;Infertility;insight;male;Male Infertility;Measures;men;Messenger RNA;Methodology;Modification;Molecular;mouse model;Pathway interactions;Phenotype;Physiological;Poly(A) Tail;Polyadenylation;posttranscriptional;Process;Production;protein complex;reproductive system disorder;Resolution;RNA;RNA metabolism;RNA Processing;RNA-Binding Proteins;Rodent;Role;sex;Sorting;sperm cell;Spermatogenesis;Transcript;Transferase;Translations;Woman

PROJECT_TITLE: Role of RNA modifications in spermatogenesis.


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Coronaviruses;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Vaccine Related

PI_NAMEs: BORGNIA, MARIO  (contact)

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;Antigens;Biocompatible Materials;Biological;Biological Preservation;Biophysics;Cell membrane;Cells;Characteristics;Chimeric Proteins;Collaborations;Coronavirus spike protein;COVID-19;COVID-19 pandemic;Cryo-electron tomography;Cryoelectron Microscopy;cryogenics;Data;Development;Disease Outbreaks;Dissection;Ebola virus;Electron Microscope;Environment;Epithelium;Epitopes;fighting;Glycoproteins;glycosylation;Goals;HIV;HIV/AIDS;Human;Image;image processing;immunogenicity;Infection;instrumentation;interest;Ions;Light;Lipid Bilayers;Macromolecular Complexes;macromolecule;Mammalian Cell;Maps;Mediating;Membrane;Methods;Modeling;Molecular;Molecular Conformation;Molecular Machines;Molecular Structure;mutant;Names;National Institute of Environmental Health Sciences;neutralizing antibody;novel strategies;particle;Pathogenesis;Peptides;Personal Satisfaction;Population;Process;Proteins;receptor;Resolution;Resort;Sampling;SARS-CoV-2 spike protein;Scanning;Series;Specimen;Structure;Surface;System;Techniques;temporal measurement;Thick;Thinness;tool;Universities;vaccine development;Vaccines;Viral;Viral Vector;Virion;Virus;Virus Diseases

PROJECT_TITLE: Epitope dynamics and functional analysis of viral envelope glycoprotein by cryo-electron tomography and single particle cryo-EM


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases

PROJECT_TERMS: 2019-nCoV;Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Anti-Inflammatory Agents;Binding;CD44 Antigens;Cells;Clinical Trials;Coagulation Process;COVID-19;COVID-19 complications;COVID-19 treatment;Development;Disease;effective therapy;Endothelium;Epithelium;Extracellular Matrix;fighting;global health emergency;Glycosaminoglycans;Human;Hyaluronan;in vivo;Infection;Inflammation;Influenza;Inhalation;inhibitor;inhibitor therapy;Injury;inter-alpha-inhibitor;Legal patent;Life;Lung;Lung infections;lung injury;lung repair;Mediating;Mediator;Modeling;Molecular Weight;Morbidity - disease rate;mortality;mouse model;pandemic disease;Paper;Patients;Peptides;Process;Property;Protease Inhibitor;Proteins;receptor;repaired;Reporting;research clinical testing;Resolution;Respiratory Failure;response;SARS-CoV-2 entry inhibitor;SARS-CoV-2 infection;Sepsis;Serine Protease;Serine Proteinase Inhibitors;severe COVID-19;Source;sugar;Therapeutic;Thrombosis;Toxicant exposure;Viral;viral entry inhibitor;Viral Physiology;Virus Diseases;Work

PROJECT_TITLE: Harnessing the power of extracellular matrix to treat COVID-19 ARDS


NIH_SPENDING_CATS: Coronaviruses;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases

PROJECT_TERMS: 2019-nCoV;Ablation;ACE2;Angiotensin II;Angiotensins;Binding;Binding Proteins;Biological Assay;Cell surface;Cells;ChIP-seq;Chromatin;Chromatin Remodeling Factor;Cryoelectron Microscopy;Data;druggable target;Epigenetic Process;epigenetic regulation;Equilibrium;gene repression;Genomics;heart cell;Hi-C;Human;Infection;Mechanical Stress;Molecular;mRNA Expression;Mus;novel;Organ;programs;promoter;protein expression;receptor;recruit;Repression;Sensory;structural biology;Tissues;transcriptome sequencing;Up-Regulation;X-Ray Crystallography

PROJECT_TITLE: SMCHD1 and epigenetic regulation of ACE2


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence

PI_NAMEs: ANCHANG, BENEDICT  (contact)

PROJECT_TERMS: Algorithms;Antigens;autoencoder;Automobile Driving;B-Lymphocytes;Back;Behavior;Beta Cell;Biological Markers;Biological Phenomena;Biological Process;biological systems;cell behavior;Cell Differentiation process;Cell Physiology;Cells;Collaborations;Communication;Data;data integration;data reduction;Data Set;data visualization;Dependence;design;Development;Developmental Process;differential expression;Disease;Drug Targeting;Effectiveness;Endocrine;Endocrine system;Epithelial Cells;Epithelium;Gene Expression Profile;gene regulatory network;Genes;Genetic;Genetic Transcription;Goals;high dimensionality;Immune;Immune response;Immune system;Immunotherapy;improved;Individual;Injury;insight;interest;Interleukin-2;Interleukin-4;Knockout Mice;Location;Lung;lymphocyte proliferation;Malignant Neoplasms;Maps;Measures;Melanoma;Mesenchymal;Methods;Modeling;mouse model;multidimensional data;multiplexed imaging;Mutation;Neighborhoods;network models;Network-based;novel;Pathway interactions;Pattern;Performance;pharmacologic;Phenotype;Placentation;Plasma;Process;Proliferating;Proteins;Publishing;Reporting;reproductive;Reproductive system;respiratory;Respiratory System;single cell analysis;single-cell RNA sequencing;spatial relationship;spatiotemporal;Spermatogenesis;Stem cell pluripotency;System;Systems Biology;T-Cell Activation;T-Lymphocyte;Techniques;Time;Tissue imaging;Tissues;tool;tool development;treatment response;Trees;tumor microenvironment;tumor progression;Validation;Variant;Visualization;Work

PROJECT_TITLE: Single-cell Analysis of Normal and Perturbed Dynamic and Spatial  Biological Systems


NIH_SPENDING_CATS: Bioengineering;Prevention

PI_NAMEs: PAREKH, ANANT  (contact)

PROJECT_TERMS: A kinase anchoring protein;Address;airborne allergen;Animal Disease Models;Apoptosis;Area;Asthma;Atopic Dermatitis;Autoimmunity;Biochemical;Calcium;Calcium Channel;Calcium Signaling;Cell membrane;Cell model;Cell Physiology;cell type;Cells;Chemicals;Clinical;Complex;Confocal Microscopy;cytokine;Disease;Electrophysiology (science);Endoplasmic Reticulum;Environment;environmental intervention;Exocytosis;fluorescence imaging;Fluorescence Resonance Energy Transfer;Gene Expression;Goals;Growth;Health;Hypersensitivity;Immune system;immunocytochemistry;In Vitro;in vivo;interdisciplinary approach;interest;Malignant Neoplasms;mathematical model;Measurement;Membrane;Microscopy;mitochondrial metabolism;Molecular;Molecular Biology;Motility;mouse model;patch clamp;Pathologic Processes;Pathway interactions;Physiological Processes;prevent;Production;Proteins;pulmonary function;Pyroglyphidae;receptor;Regulation;release of sequestered calcium ion into cytoplasm;Research;Role;Scaffolding Protein;sensor;Signal Pathway;Signal Transduction;Site-Directed Mutagenesis;skin organogenesis;small molecule;Surface;System;Techniques;Transfection;Transgenic Mice

PROJECT_TITLE: Calcium Signaling in Health and Disease


PROJECT_TERMS: 2019-nCoV;Affect;Book Chapters;Cells;Coronavirus;Data;Enzymes;established cell line;Family;genetic regulatory protein;Genome;Goals;Infection;insight;Length;Manuscripts;Measures;meetings;Metabolism;Methods;Modification;Molecular;Oral;Pathway interactions;Peer Review;Poly(A) Tail;Poly(A)+ RNA;previous pandemic;Process;Proteins;Protocols documentation;Publishing;RNA;RNA chemical synthesis;RNA Processing;RNA replication;RNA-Binding Proteins;Role;viral RNA;Virus;Virus Replication

PROJECT_TITLE: Role of RNA modifications in coronaviruses replication


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: GJONESKA, ELIZABETA  (contact)

PROJECT_TERMS: Adult;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Autopsy;Brain;brain cell;brain tissue;Chromatin;Chromatin Remodeling Factor;Development;Disease;Disease Progression;DNA;Encephalitis;Environmental Risk Factor;Event;fetal;Functional disorder;Gene Expression;Genetic;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Genetic Transcription;genomic tools;Immune;immune function;Immune response;Impaired cognition;in vivo;insight;Maps;Mediating;Microglia;Molecular;mouse model;Nerve Degeneration;novel therapeutic intervention;Nucleic Acid Regulatory Sequences;Pathologic;Pathway interactions;Predisposition;programs;Proteins;Regional Disease;Regulation;Research;risk variant;Role;sensor;Symptoms;systemic inflammatory response;transcription factor;treatment strategy;Untranslated RNA

PROJECT_TITLE: MECHANISMS UNDERLYING MICROGLIA DYSFUNCTION DURING NEURODEGENERATION


NIH_SPENDING_CATS: Genetics

PI_NAMEs: WATTS, JASON  (contact)

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Affect;Base Pairing;Base Sequence;Cell Nucleus;Cell Physiology;cell type;Cells;Code;Coupled;Couples;Disease;DNA;DNA Polymerase II;DNA-Directed RNA Polymerase;Elements;Enhancers;Environmental Exposure;Focus Groups;Gene Expression;Gene Expression Regulation;Generations;Genes;genetic regulatory protein;Genetic Transcription;Genome;genome-wide;Goals;Guanine;Heavy Metals;Human;human disease;Impairment;Kidney;Link;Location;Mediating;Mitochondria;Mitochondrial RNA;Modeling;Movement;nucleic acid structure;Nucleic Acids;Osmosis;Output;Pattern;Pesticides;Polymerase;Production;promoter;Property;protein complex;Proteins;Regulation;Regulatory Element;response;RNA;RNA Processing;Role;Site;small molecule;Specificity;Stress;stressor;Structure;System;Transcription Elongation;transcription factor;Transcriptional Regulation;Work

PROJECT_TITLE: cis-regulation of RNA polymerase pausing


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Contraception/Reproduction;Endocrine Disruptors;Genetics;HIV/AIDS;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

PI_NAMEs: GUARDIA, CARLOS  (contact)

PROJECT_TERMS: adverse outcome;Affect;Alleles;Autophagocytosis;Biochemical;Biochemistry;Cardiovascular Diseases;Cell fusion;Cell Line;Cell Physiology;Cells;Cellular biology;Child;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;cytotoxicity;Development;Disease;Electrons;Embryo;Embryo Deaths;Embryonic Development;endothelial dysfunction;Environment;experimental study;extracellular vesicles;Face;Failure;Fetal Death;Fetal Development;Fetal Growth;Fetal Growth Retardation;Fetus;Fluorescence;Gene Expression;Genes;Goals;Hormone secretion;Hospitals;Human;Hypertension;In Vitro;Kidney Diseases;Knock-out;Life;LoxP-flanked allele;Maintenance;Microscopy;Modeling;Molecular;Monitor;Mothers;mouse model;Mus;novel;novel therapeutics;Organ;Pathway interactions;Physiological;Placenta;Placenta Diseases;Placental Biology;placental trophoblasts;Placentation;Play;Poly-fluoroalkyl substances;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnant Women;Proteinuria;Protocols documentation;Research;Role;Specific qualifier value;stillbirth;Stress;Techniques;Technology;Testing;Tissues;tool;Toxic effect;trafficking;trophoblast;Vascular blood supply

PROJECT_TITLE: Autophagy and Intracellular Trafficking in Placental Biology


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Address;Adopted;Algorithms;autoencoder;Bayesian Modeling;Benchmarking;Biological;Biological Process;Biomedical Research;Cell Communication;Cells;Complex;complex data;computer framework;computerized tools;Data;data complexity;data integration;data reduction;Data Set;Dependence;design;Developmental Process;dimension reduction;Dimensions;Disease;Epithelium;gradient boosting;Heterogeneity;high dimensionality;Immune;improved;indexing;Individual;insight;interest;Lead;Mesenchymal;Methods;multidimensional data;Neurons;novel;Occupations;Organ;Output;Performance;Placenta;Placentation;Pregnancy;preservation;Process;single cell analysis;spatiotemporal;Spermatogenesis;Stem cell pluripotency;Stromal Cells;Structure;Time;Tissues;tool;Translating;trophoblast;Visual;Visualization

PROJECT_TITLE: Benchmarking and Computational framework for Optimal Visualization and Interpretability of high-dimensional Spatiotemporal Data


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Contraception/Reproduction;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Maternal Health;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

PI_NAMEs: PEDDADA, SHYAMAL  (contact)

PROJECT_TERMS: Affect;Aridity;Biological;Biology;Biomedical Research;Birth;Birth Rate;Birth Weight;Childbirth;circadian pacemaker;Climate;climate change;Cohort Studies;cold temperature;Colorado;Complex;Conceptions;Country;Data;Data Analyses;Data Set;Databases;Dependence;Disease;Dose;economic indicator;Ecosystem;Endocrinology;Evaluation;Experimental Designs;experimental group;female fertility;Fertility;fetal;Fetal Development;Genes;Goals;high dimensionality;Hormones;Human;Human Chorionic Gonadotropin;Illinois;interest;Iowa;Linear Regressions;Literature;male fertility;Manuscripts;Measures;Mediation;Mediator;Methodology;Methods;Michigan;Microbe;microbiome;microbiome research;Modeling;multidimensional data;National Institute of Child Health and Human Development;National Oceanic and Atmospheric Administration;Nature;New York;novel;Operative Surgical Procedures;Outcome;Participant;Patients;Pattern;Pennsylvania;Periodicity;pesticide exposure;Pesticides;Placenta;Population;population health;Pregnancy;Premature Birth;prenatal testing;Procedures;Publications;Publishing;Reporting;Reproductive Health;reproductive outcome;Research;Research Personnel;response;screening program;Shapes;socioeconomics;Soil;spatiotemporal;Structure;tau Proteins;Technology;Testing;Texas;Time;Utah;Work;Yin

PROJECT_TITLE: Constrained Statistical Inference


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Maternal Health;Microbiome;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adolescence;Adolescent;Adverse effects;Antibiotics;Bacteria;Biological Markers;Biology;Biometry;Birth;Blood;C-Peptide;Cesarean section;Chemicals;Child;cohort;Collaborations;Communication;Complex;County;cytokine;Data;Development;Developmental Delay Disorders;early life exposure;Education;Environment;Exposure to;Extramural Activities;Feces;follow-up;Genetic;gut microbiota;Health;high risk sexual behavior;HIV-1;Human;Immune response;Individual;Infection;Inflammatory;Insulin Resistance;interest;Joints;Link;Literature;low socioeconomic status;Manuscripts;Mediating;Mediation;men who have sex with men;Metabolic syndrome;microbiome;microbiota composition;Mothers;Nature;Neonatal;neonatal exposure;Norway;novel;Obesity;Outcome;Overweight;Parenting Education;Pathogenicity;Personal Satisfaction;prevent;Process;Prospective Studies;Publications;recruit;Reporting;Research;Research Project Grants;Risk;Sampling;Scientist;Sex Behavior;Sexual Partners;socioeconomics;Techniques;Time;ward;Weight;Women's study;Work

PROJECT_TITLE: Collaborative Biostatistical Research


PROJECT_TERMS: Affect;Animal Model;Bioinformatics;Blood specimen;Candidate Disease Gene;Clinical;clinical heterogeneity;Collaborations;Collection;Data;data sharing;Delayed Puberty;Development;Disease;DNA;Enrollment;exome;exome sequencing;Family;Family member;Functional disorder;Future;Genes;Genetic;genetic analysis;genetic linkage analysis;genetic variant;Genome;genomic data;Genomics;GNRH1 gene;Gonadotropins;Growth;Hereditary Disease;Human;human model;Hypogonadism;Idiopathic Hypogonadotropic Hypogonadism;Impairment;Individual;insight;Investigation;Klinefelter's Syndrome;member;Mutation;National Human Genome Research Institute;National Institute of Environmental Health Sciences;Neurons;novel;Oligonucleotides;Participant;Pathway interactions;Patients;Phenotype;Precocious Puberty;proband;Puberty;Questionnaires;Regulation;Reproduction;reproductive;saliva sample;Sampling;Services;Sexual Maturation;smell test;Syndrome

PROJECT_TITLE: Investigation of the genetic cause of inherited disorders of reproduction


NIH_SPENDING_CATS: Biotechnology;Genetics

PI_NAMEs: ELANGO, RAJULA  (contact)

PROJECT_TERMS: Address;Binding;BRCA1 gene;BRCA2 gene;Bypass;Camptothecin;Cell Cycle;Chemicals;chemotherapeutic agent;clinically relevant;CRISPR/Cas technology;DNA;DNA Double Strand Break;DNA lesion;DNA Repair;DNA Repair Gene;DNA replication fork;DNA-protein crosslink;Endonuclease I;Engineered Gene;environmental stressor;Event;Excision;Exposure to;FLP recombinase;gene-targeted therapy;Generations;Genetic;Genetic Engineering;Genomic Instability;Goals;Health;High-Throughput Nucleotide Sequencing;homologous recombination;Human;Lesion;Ligation;Mammalian Cell;Mammals;Mediating;Modeling;Molecular;Outcome;Pathway interactions;Poison;Process;Regulation;repaired;Resolution;Role;S phase;Single Strand Break Repair;Site;System;Techniques;Technology;Type I DNA Topoisomerases;Tyrosine

PROJECT_TITLE: Unraveling the molecular mechanisms of DNA-protein crosslink repair in mammals and understanding its impact on human health


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases;Microbiome

PROJECT_TERMS: Address;Antibiotics;Antimicrobial Resistance;antiretroviral therapy;Birth;climate change;Clinical;Computing Methodologies;Data;DNA;drug resistant pathogen;Escherichia coli;Feces;Gender;geographic difference;Geographic Locations;Geography;gut microbiome;gut microbiota;HIV;HIV anti-retroviral;HIV Infections;Infection;Intervention;Klebsiella pneumoniae;Literature;Metagenomics;microbiome;microbiota;multidimensional data;novel;Oral;oral microbial community;oral microbiome;Participant;Persons;Phase;Process;Public Health;Radiation;resistance gene;Salmonella;Sampling;sex;Sex Behavior;Shigella;Shotguns;Staphylococcus aureus;stool sample;Streptococcus pneumoniae;The Multicenter AIDS Cohort Study;transmission process;Universities;Women's Interagency HIV Study

PROJECT_TITLE: Antimicrobial resistance genes and interactions with the microbiota in people with HIV


NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Anatomy;Antigens;Biological Assay;Biological Markers;Biological Specimen Banks;Categories;Chronic;Clinic Visits;Clinical;Complex;Data;Development;Disease;Disease Progression;dysbiosis;Ecosystem;Feces;Goals;Growth;gut microbiome;gut microbiota;Health;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;HIV/AIDS;immune activation;Immunity;Inflammation;interest;Investigation;Knowledge;Link;Literature;men who have sex with men;men's group;metabolomics;metagenome;Metagenomics;Microbe;microbial;microbial genome;microbiome;Onset of illness;Oral;oral microbial community;oral microbiome;Pathogenesis;Pathogenicity;Phase;Plasma;potential biomarker;Process;public database;Quality Control;Reporting;Research;Risk;Risk Estimate;Role;Sampling;screening;seroconversion;stool sample;Time;Uncertainty;Visit

PROJECT_TITLE: Investigation of dysbiosis in oral and gut microbiome in HIV infection


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

PI_NAMEs: LISCHINSKY, JULIETA  (contact)

PROJECT_TERMS: Adult;Aggressive behavior;Amygdaloid structure;Behavior;behavioral outcome;Brain;Caring;Cell Physiology;Cells;Cues;Development;early life adversity;Ejaculation;Embryo;Environment;experience;FOXP2 gene;Generations;Goals;Hypothalamic structure;in vivo;infancy;information processing;Instinct;interest;life span;Limbic System;male;Medial;Molecular;Motor output;Mus;Nature;Neurons;Partner in relationship;Physiological;Population;Process;response;Sensory;sex;Shapes;social;Social Behavior;Testing;Toxic Environmental Substances;transcription factor;Work

PROJECT_TITLE: Developmental, cellular and circuit mechanisms for social behaviors in the limbic system across sexes.


ACTIVITY: ZIC

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

PI_NAMEs: HOLLAND, STEVEN  (contact)

PROJECT_TERMS: 2019-nCoV;Acute;Animals;Anti-Inflammatory Agents;anti-microbial peptide;Antitubercular Agents;Attenuated;bevacizumab;Blood Vessels;Callithrix;Callithrix jacchus jacchus;Cellular biology;chemotherapy;Clinical assessments;Clinical Research;Collaborations;Combined Modality Therapy;Computed Tomography Scanners;COVID-19;cytokine;Data;Data Set;Development;Discipline of Nuclear Medicine;Disease;Disease Progression;Dose;Drug Delivery Systems;drug efficacy;Drug Transport;efficacy evaluation;enzyme activity;Evaluation;experimental study;Extracellular Matrix;Extramural Activities;FDA approved;fluorodeoxyglucose;Gene Expression;General Hospitals;Genus Mycobacterium;Goals;Granuloma;Image;Image Analysis;imaging program;Imaging Techniques;immunogenicity;Immunologics;Immunology;improved;in silico;in vivo;Individual;Infection;Infectious Diseases Research;Inflammatory;inflammatory marker;Interferon Type II;Interleukin-10;Intramural Research Program;Investigation;Lesion;Losartan;Lung;lung lesion;Macaca;Macaca mulatta;male;Measures;Mediating;Medical Imaging;Methods;Modeling;Molecular Medicine;Monitor;Moxifloxacin;multidisciplinary;Murine pneumonia virus;Mus;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;novel;nuclear imaging;Nutrient;Oryctolagus cuniculus;Oxygen;Penetration;Pharmaceutical Preparations;Pharmacotherapy;Positron-Emission Tomography;preventive intervention;Procedures;programs;protective efficacy;Proteins;prototype;Publishing;quantitative imaging;Regimen;Reporter;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;Resolution;response;RNA Viruses;Role;SARS-CoV-2 infection;Serum Markers;Speed;T memory cell;T-Lymphocyte;Therapeutic;Therapeutic Intervention;Tissues;Tracer;transcriptome sequencing;treatment effect;Treatment outcome;Trehalose;trend;Tuberculosis;tuberculosis drugs;tuberculosis granuloma;tuberculosis treatment;tumor;Universities;unvaccinated;uptake;vaccination strategy;vaccine candidate;vaccine efficacy;Vaccine Research;vector;Viral;Virus;Virus Replication;Work;X-Ray Computed Tomography

PROJECT_TITLE: Tuberculosis Imaging Program


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Genetic Testing;Genetics;HIV/AIDS;Health Services;Human Genome;Mental Health;Patient Safety;Primary Immunodeficiencies;Rare Diseases

PROJECT_TERMS: Address;algorithmic methodologies;Algorithms;Anxiety;Atopic Dermatitis;Attention;Awareness;Behavioral;Behavioral Research;Caring;Certification;Classification;Clinical;clinical center;clinical diagnostics;clinical implementation;Clinical Research;Cognitive;cohort;Collaborations;Communities;Complex;Comprehension;Confidentiality of Patient Information;Consent;Consultations;Data;Data Collection;data sharing;database of Genotypes and Phenotypes;Decision Making;deep sequencing;Deposition;design;Development;Diagnosis;Diagnostic Services;Disease;Education;Emotional;Enrollment;Evaluation;Evolution;exome;experience;Feedback;follow-up;GATA2 deficiency;Genes;Genetic;Genetic Counseling;genetic counselor;genetic testing;Genome;genomic data;genomic variation;Genomics;Genotype;Guidelines;Health Services Accessibility;Hospitals;improved;Individual;Infrastructure;interest;Interview;Intramural Research;Intramural Research Program;Job's Syndrome;Knowledge;knowledge base;Language;lectures;Life;Manuscripts;Measures;Medical;Medicine;meetings;Mental Depression;Mental Health;Methods;Minority;Mission;Modeling;Molecular;molecular diagnostics;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;National Institute of Allergy and Infectious Disease;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Child Health and Human Development;National Institute of Dental and Craniofacial Research;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;Newly Diagnosed;Participant;participant enrollment;Pathogenicity;patient portal;Patients;Pharmaceutical Preparations;Pharmacogenomics;Phenotype;Policies;polygenic risk score;Population;Preparation;proband;Productivity;programs;Protocols documentation;psychologic;Psychological adjustment;psychological outcomes;Publications;Quality of Care;Rare Diseases;Reaction;Recommendation;Reporting;reproductive;Research;Research Personnel;Risk;Robotics;Rotation;Running;sample collection;Secure;Series;Services;Shapes;social;Somatic Mutation;Source;Structure;success;Surveys;Technology;technology development;Testing;Time;Training;treatment-resistant depression;Trinucleotide Repeats;Uncertainty;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Centralized Sequencing Program


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PI_NAMEs: GERRISH, KEVIN  (contact)

PROJECT_TERMS: Address;Bioinformatics;Computer software;Custom;Development;DNA Methylation;Embryo;Ensure;Environment;experimental study;Gene Expression;Gene Expression Profiling;genome-wide;genome-wide analysis;Genomics;Health;Human;human disease;improved;Lasers;MicroRNAs;Mission;Modification;Molecular;nano-string;National Institute of Environmental Health Sciences;programs;Protocols documentation;RNA;Sampling;Scientist;Source;System;Technology;Testing;Tissues;transcriptome

PROJECT_TITLE: Gene Expression and Microarrays


NIH_SPENDING_CATS: Lung;Neurosciences

PI_NAMEs: TUCKER, CHARLES  (contact)

PROJECT_TERMS: 3-Dimensional;ABCB1 gene;Alleles;Alprostadil;analog;APOCEC3G gene;Area;base;Bibliography;Birds;bisphenol A;Blood - brain barrier anatomy;Brain;Bromodomain;Catecholamines;Cells;Cervical;channel blockers;Cisplatin;Collaborations;Development;Diphosphates;Endocrinology;Ensure;entorhinal cortex;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Equipment;erastin;ESR1 gene;Exposure to;Extracellular Matrix;Fibroblasts;Fibrosis;Fluorescence;fluorescence imaging;Fluorescence Microscopy;Fright;Gene Expression Regulation;Glucocorticoids;Goals;Hamsters;hazard;Heart failure;Heterogeneity;Hippocampus;Hormone Receptor;HPV positive;Human;human induced pluripotent stem cells;imaging facilities;Immune;Innate Immune Response;inorganic phosphate;Inositol;insight;investigator training;Investments;Knock-in;Knowledge;Laboratories;Life;Lip structure;Lung;lung cancer cell;Malignant Neoplasms;Mediating;meetings;memory consolidation;Microglia;Microtus;Mineralocorticoids;Mission;Modeling;Monitor;Moon;Morphology;Mus;Naloxone;National Institute of Environmental Health Sciences;non-genomic;Non-Small-Cell Lung Carcinoma;Norepinephrine;Optics;Organelles;Physical condensation;Platelet-Derived Growth Factor alpha Receptor;Protocols documentation;Psychiatry;Publications;PubMed;receptor;Receptor Activation;receptor function;Receptor Protein-Tyrosine Kinases;recombinase;Regulation;Research;Research Personnel;Respiratory Syncytial Virus Infections;Role;Scientist;Services;sex;Signal Transduction;skills;Smith-Lemli-Opitz Syndrome;stem cells;Sterol Biosynthesis Pathway;Stress;Techniques;Technology;TGFB1 gene;Thyroid Gland;Tobacco smoke;tool;TP53 gene;Training;uptake;Uterine Fibroids;ward;Wine;Work

PROJECT_TITLE: Fluorescence Microscopy


PI_NAMEs: BORTNER, CARL  (contact)

PROJECT_TERMS: Area;Biochemical;burden of illness;Cell Cycle;Cell Death;Cell Separation;Cell Size;Cells;Clinical Research;Color;computer program;Computer software;Cytometry;Data Analyses;Dedications;Energy Transfer;Environment;environmental agent;Experimental Designs;Flow Cytometry;Fluorescence;Functional disorder;Goals;Human;Immunophenotyping;Individual;Injections;instrument;instrumentation;Investigation;Ions;Knowledge;Mission;National Institute of Environmental Health Sciences;operation;Organelles;Phosphorylation;protein expression;release of sequestered calcium ion into cytoplasm;Research Personnel;Resources;Sampling;Scientist;single cell analysis;Sorting;Technology;Training;translational study

PROJECT_TITLE: Flow Cytometry


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: PETROVICH, ROBERT  (contact)

PROJECT_TERMS: 2019-nCoV;Allergens;Allergy to peanuts;Antibodies;Apoferritin;ATP phosphohydrolase;Bacteria;Baculoviruses;Biological Assay;biophysical properties;C-terminal;Cell Culture Techniques;Cell Line;Cells;Chinese Hamster Ovary Cell;Cloning;Co-Immunoprecipitations;Codon Nucleotides;Collaborations;Collection;COVID-19;Cryoelectron Microscopy;Crystallography;Culture Media;Data;Dermatophagoides pteronyssinus antigen p 2;Dermatophagoides pteronyssinus antigen p 7;design;design and construction;Escherichia coli;experimental study;expression vector;Felis catus;Future;Gene Targeting;Generations;Genes;genome integrity;Glutathione S-Transferase;Grouping;Hand;Hela Cells;Hydrostatic Pressure;Hypersensitivity;Immunotherapy;in vivo;Inclusion Bodies;India;Infection;Insecta;interest;Laboratories;Learning;Lipopolysaccharides;Macromolecular Complexes;maltose-binding protein;Mammalian Cell;Mediating;member;Methodology;Methods;Mission;Modeling;Molecular Chaperones;Monoclonal Antibodies;Motor;multicatalytic endopeptidase complex;mutant;N-terminal;nanobodies;National Institute of Environmental Health Sciences;NuRD complex;Open Reading Frames;particle;Patients;Persons;Physicians;Plant Resins;Post-Translational Protein Processing;Principal Investigator;Process;protein aggregation;protein complex;protein expression;protein folding;Protein Fragment;protein purification;Proteins;Protocols documentation;Research;Research Personnel;response;Ribosomes;Roentgen Rays;Running;Sampling;SARS-CoV-2 B.1.1.529;SARS-CoV-2 B.1.1.7;SARS-CoV-2 B.1.351;SARS-CoV-2 B.1.617.2;SARS-CoV-2 P.1;SARS-CoV-2 variant;scale up;Series;stable cell line;structural biology;Structure;Support Groups;System;Techniques;Technology;Temperature;Testing;Time;Transfection;TXN gene;United States National Institutes of Health;Variant;vector;Viral;Viral Proteins;Viral Vector;Virus;Virus Diseases;virus testing;Work;X-Ray Crystallography

PROJECT_TITLE: Protein Expression Facility


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Gene Therapy;Genetics;Infectious Diseases

PI_NAMEs: YAKEL, JERREL L (contact)

PROJECT_TERMS: 2019-nCoV;Accountability;Adenoviruses;animal tissue;Biochemical;Biological;Biological Assay;cell immortalization;Cell Line;Cells;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Consultations;Core Facility;Coronavirus;cost;cost effective;Dependovirus;Development;Developmental Biology;Disease;embryo cell;Ensure;Epigenetic Process;Gene Delivery;Genes;Genetic;genome integrity;Guidelines;Hematopoietic;HIV;HIV-1;Hormone Receptor;human coronavirus;Immunity;Immunologics;In Vitro;in vivo;Inflammation;Influenza A virus;influenzavirus;Integrase;Ion Channel;knock-down;Laboratories;Lentivirus;Lentivirus Vector;Lymphocytic choriomeningitis virus;Mission;Modification;Mus;National Center for Complementary and Integrative Health;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Environmental Health Sciences;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;Neurobiology;Pathway interactions;Primary Cell Cultures;Principal Investigator;Production;programs;protein expression;protein purification;Protein Secretion;Protocols documentation;Rabies;Rattus;Reagent;Recombinants;Reproductive Biology;Research;Research Personnel;Research Support;Respiratory syncytial virus;Retroviridae;Safety;Sampling;SARS coronavirus;SARS-CoV-2 spike protein;Services;Signal Transduction;Simplexvirus;Sindbis Virus;small hairpin RNA;stable cell line;stem cell biology;structural biology;System;Technology;Time;tissue culture;Tissues;Toxicology;Training;transcription factor;Transfection;Transgenic Animals;United States National Institutes of Health;Validation;vector;Vesicular stomatitis Indiana virus;Viral;viral gene delivery;Viral Vector;Virion;Virus;Zika Virus

PROJECT_TITLE: Viral Vector Core


PROJECT_TERMS: Acceleration;Automation;Bioinformatics;clinical phenotype;Complex;Consumption;cost;Cost aspects;Data Analyses;design;Development;Disease;DNA;DNA Resequencing;Environment;Environmental Health;Gel;gene environment interaction;Genes;Genetic;Genetic study;genetic technology;Genetic Variation;Genomics;Genotype;Goals;human disease;Infrastructure;Manuals;method development;Methods;Molecular Genetics;Mus;National Institute of Environmental Health Sciences;novel therapeutics;Nucleic Acids;Prevention therapy;Productivity;Reaction;Research;Research Personnel;Research Support;Resources;Role;Sampling;Scientist;Services;Susceptibility Gene;Tail;Technology;Time;tool;Toxic effect;working group

PROJECT_TITLE: Molecular Genetics Support to Identify Gene/Environment Interactions in Disease


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Adoption;Antineoplastic Agents;Bacterial Drug Resistance;Biological Process;Cellular Stress;Collaborations;collaborative environment;Complex;Computer software;Core Facility;COVID-19;Cryoelectron Microscopy;cryogenics;Crystallization;Data;Data Collection;Dementia;Deposition;Development;Disease;Drug Delivery Systems;Electron Microscope;Electron Microscopy;electron tomography;Engineering;Ensure;Equipment;Evaluation;Genetic Diseases;Goals;image processing;improved;In Situ;Machine Learning;Macromolecular Complexes;macromolecule;Membrane Proteins;Metabolic Pathway;method development;Methods;Microscopy;Mission;Mitochondria;Molecular;Molecular Structure;National Institute of Environmental Health Sciences;new technology;novel strategies;Nuclear Magnetic Resonance;Pain;Parkinson Disease;particle;Preparation;Process;Publications;Research;Research Project Grants;Resolution;response;Robot;Robotics;Role;Sampling;Specimen;Structural Biologist;structural biology;Structure;Techniques;Time;Titan;tomography;tool;Training;Viral Proteins;X-Ray Crystallography

PROJECT_TITLE: NIEHS Cryo-EM Core Facility


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Prevention;Social Determinants of Health

PI_NAMEs: HALL, JANET  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Affect;Alcohol consumption;Alcohols;Area;Asthma;Back;Behavior;biobank;Biological;Blood;Characteristics;Chemical Exposure;Clinical Research;Code;Cohort Studies;Collaborations;Complex;Coupled;COVID-19;Data;Data Collection;Dedications;demographics;design;Diabetes Mellitus;Diagnosis;Diet;Disease;disorder risk;DNA;Eligibility Determination;Enrollment;Environment;Environmental Exposure;Environmental Health;Environmental Risk Factor;epigenomics;Extramural Activities;Family;Family history of;follow-up;Follow-Up Studies;Future;gene environment interaction;Gene Expression;Genes;Genetic;Genetic Polymorphism;Genetic study;Genome;genome sequencing;Genotype;Goals;Health;health determinants;Heart Diseases;Home;Human;human coronavirus;human disease;Individual;Infrastructure;instrument;knowledge base;Life;Life Cycle Stages;life span;Life Style;lifestyle data;lifestyle factors;Link;Malignant Neoplasms;Measurement;Measures;Medical;Medical History;National Health and Nutrition Examination Survey;National Institute of Environmental Health Sciences;Nature;novel coronavirus;Occupational Exposure;Operative Surgical Procedures;Participant;participant enrollment;Pathogenesis;perceived stress;Pharmaceutical Preparations;Phenotype;PhenX Toolkit;Physical activity;Physicians;Physiological;Population;precision medicine;Predisposition;prevent;Questionnaires;Recontacts;Recording of previous events;Registries;Research;Research Personnel;research study;Resources;response;Risk;Sampling;SARS coronavirus;Scientist;Self Administration;Severe Acute Respiratory Syndrome;Sleep;Smoking;Smoking History;Socioeconomic Status;Stress;study population;Study Subject;Surveys;tool;translational health science;United States National Institutes of Health;Update;Variant;Visit;whole genome;Work

PROJECT_TITLE: Personalized Environment and Genes Study (PEGS)


NIH_SPENDING_CATS: Genetics;Human Genome

PI_NAMEs: LI, JIAN-LIANG  (contact)

PROJECT_TERMS: 2019-nCoV;Atlases;Bioinformatics;bioinformatics resource;bioinformatics tool;Biological;Biometry;Cells;Collaborations;Collection;Communities;Complex;Computer Analysis;computer infrastructure;Computer software;Core Facility;Data;Data Analyses;data standards;Dedications;design;Development;diverse data;Educational workshop;empowerment;Endocrine;experience;experimental study;genome annotation;Goals;improved;Individual;Informatics;Internships;Intramural Research;Knowledge;Learning;member;metabolomics;Methods;microbiome;multiple omics;National Human Genome Research Institute;National Institute of Environmental Health Sciences;next generation sequence data;Participant;Play;Postdoctoral Fellow;programs;Proteomics;Publications;PubMed;Reporting;Research;Research Personnel;Resources;Role;Scientist;Series;single cell analysis;skills;Sorting;Students;Support Groups;tool;Training;transcriptome sequencing;transcriptomics;Visit;Work

PROJECT_TITLE: Integrative Bioinformatics