NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Currently, over six million Americans are living with Alzheimer's disease (AD), and by 2050 this number is projected to rise to nearly 13 million if no disease-modifying treatments are discovered. The lack of successful therapeutic options can be attributed to the complexity of AD and the limited understanding of the genetic and neuronal mechanisms that underly AD. I performed genetic mapping of brain-composition traits in a panel of genetically diverse mice that model human AD to identify Lrfn2 as a gene that modifies AD-related cortical neurodegeneration, and in the proposed project I will determine if Lrfn2 is a genuine mediator of resilience to AD and is a valid target for development of effective treatments for AD.

PI_NAMEs: GURDON, BRIANNA  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Achievement;Age;Age Months;Aging;Alleles;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease therapeutic;American;Animals;Apolipoprotein E;Behavior;Behavioral;Behavioral Assay;Brain;Brain Mapping;Candidate Disease Gene;career;causal variant;Cells;Chromosome Mapping;Clinical;Closure by clamp;Cognition;Cognitive;Cognitive deficits;cognitive enhancement;cognitive function;cognitive performance;cognitive task;cohort;conditioned fear;Dendritic Spines;density;Detection;Development;Disease;Disease Progression;effective therapy;Electrophysiology (science);endophenotype;excitatory neuron;Exhibits;experience;experimental study;familial Alzheimer disease;Fellowship;Female;Fibronectins;forward genetics;Functional disorder;Funding;Gene Modified;Genetic;genetic manipulation;Genetic Screening;Goals;Heritability;human model;Image;Immunohistochemistry;Impaired cognition;in vivo imaging;Inbred Strain;Knowledge;Leucine-Rich Repeat;long term memory;Long-Term Potentiation;Longevity;longitudinal human study;male;Maps;Measures;Mediating;Mediator;Membrane;Methods;microscopic imaging;Morphology;mouse model;Mus;Mutation;Nerve Degeneration;Neurons;neuropathology;novel;novel therapeutics;object recognition;older adult;Outcome;overexpression;patch clamp;Population;postsynaptic;Predisposition;Preparation;Prevalence;Property;Prosencephalon;protective effect;Proxy;Quantitative Trait Loci;Recombinant Inbred Strain;Research Personnel;resilience;resilience factor;Resolution;Resources;Role;Scientist;Short-Term Memory;skills;Source;Structure;Symptoms;Synapses;synaptic function;Synaptic plasticity;Techniques;Testing;The Jackson Laboratory;Therapeutic;Thick;Time;Training;trait;Transgenic Mice;Variant;Vertebral column;Viral;Work

PROJECT_TITLE: Lrfn2 as a Novel Resilience Factor to Protect Against Alzheimer's Disease-Related Cortical Neurodegeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


ADMINISTERING_IC: EB

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging;Cancer

ORG_CITY: East Greenwich

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative Ultrasound imaging, also known as ultrasonography, is the most widespread and accepted clinical imaging modality and offers diagnostic information throughout the human lifespan, starting prebirth. While its dynamic and scholarly research community continually improves image quality, it also develops new ways to benefit from this exciting modality that involves in-vivo biomedical ultrasound applications. This meeting will bring together scientists and trainees from a wide range of backgrounds to discuss and further ultrasonography so that those in need can benefit from lung ultrasound, virtual biopsies, immunotherapy and more, and will soon be seeing wearable ultrasound to understand better how daily activities, ailments, and disorders impact our bodies.

PI_NAMEs: KRIPFGANS, OLIVER D (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TITLE: 2024 In Vivo Ultrasound Imaging Gordon Research Conference and Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-F (J1)]


ADMINISTERING_IC: DK

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Type 2 Diabetes (T2D) is a global health pandemic that results from impaired insulin secretion, peripheral insulin resistance, obesity, overnutrition, lack of physical activity, and aging. However, genetic and physiologic data suggest that inadequate insulin secretion from the pancreatic beta () cell is the chief determinant predicting progression from insulin resistance to overt T2D. The goal of this research is to understand the mechanistic interplay between the process of store operated calcium entry (SOCE) and estrogen signaling in the  cell and will test the hypothesis that decreased SOCE leads to reduced G Protein-Coupled Estrogen Receptor signaling and loss of β cell identity and function, thereby contributing to the pathophysiology of T2D.

PI_NAMEs: MCLAUGHLIN, MADELINE RAE (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Ablation;Affect;Aging;Agonist;Alpha Cell;American;Beta Cell;Biological Assay;Biology;Biomedical Engineering;blood glucose regulation;Body Composition;Body Weight;Calcium;career;cell dedifferentiation;Cell Differentiation process;Cell Line;Cell membrane;Cell Physiology;cell type;Cells;Clinical Skills;clinical translation;Communication;Data;Development;Diabetes Mellitus;Disease;Disease Progression;Economic Burden;Endocrine;Endoplasmic Reticulum;Estradiol;Estrogen Receptors;Estrogens;euglycemia;experience;experimental study;Extracellular Space;Faculty;Failure;Fellowship;Female;Fluorescence Resonance Energy Transfer;Foundations;Functional disorder;Gene Expression Profile;Genetic;global health;Glucose Intolerance;glucose metabolism;Glucose tolerance test;Goals;GPER gene;Health;High Fat Diet;Homeostasis;hormonal signals;Hyperglycemia;Image;Immunoprecipitation;Impairment;Indiana;Individual;innovation;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;islet;Laboratories;Laboratory Finding;Ligation;Link;Maintenance;male;Measures;medical schools;Metabolic Diseases;Methods;Modeling;Molecular;mRNA Expression;Mus;Nanoscopy;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Oral;Ovariectomy;Overnutrition;pancreatic juice;pandemic disease;Pathway interactions;Peripheral;Phenotype;physical inactivity;Physicians;Physiological;Play;pre-doctoral;Process;protein expression;Receptor Activation;receptor expression;receptor function;Receptor Signaling;Research;Role;Schools;Scientist;sensor;sham surgery;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skills;STIM1 gene;Structure of beta Cell of islet;superresolution microscopy;surgical menopause;Technical Expertise;Techniques;Testing;Therapeutic;Tissues;Training;ultra high resolution;Universities;Woman;Work;Writing

PROJECT_TITLE: The Role of G Protein-Coupled Estrogen Receptor Signaling in the Maintenance of Beta Cell Identity

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Diabetes Endocrinology and Metabolic Diseases [DDK-E]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Headaches;Migraine;Neurosciences;Pain Research;Physical Activity

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative People with migraine and other neurological diseases often experience disabling discomfort from flickering light. This discomfort may be due to a mis-match in the brain between sensory expectation and experience. To test this idea, we will use personal light-logger devices to measure the visual environment of people with and without migraine, and then test predictions regarding the perception and brain responses to flicker found for these two groups.

PI_NAMEs: AGUIRRE, GEOFFREY KARL (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: behavior measurement;Brain;Code;Data;Detection;Development;Devices;Diffuse;disability burden;Disabling;Discrimination;Environment;Environmental Exposure;expectation;experience;Experimental Psychology;Exposure to;Eyeglasses;Frequencies;Functional Magnetic Resonance Imaging;Headache;Human;human model;Hypersensitivity;Image;information processing;Information Storage;Judgment;Light;Link;luminance;Measurement;Measures;Migraine;Modeling;Nervous System Disorder;neural;neuropsychiatric disorder;novel;Participant;Perception;Persons;Photophobia;Physical activity;Play;Predisposition;Property;Psychophysics;Publications;Research;Resources;response;Role;Sensory;sensory stimulus;statistics;Stimulus;Structure;symptom management;Symptoms;Testing;Time;Uncertainty;usability;Variant;Visual;Visual Cortex;Visual disability;Visual Discomfort;visual stimulus;Visual System;wearable device;Work

PROJECT_TITLE: Flicker photophobia as an experience of inefficient coding

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-A (02)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Chimeric Antigen Receptor (CAR)-T cell immunotherapy has shown impressive response rates in B cell malignancies; however, limitations to access and failure of many patients to reach complete response call for therapeutic enhancement. Although the causes for CAR-T cell failure are multiple and still emerging, the time necessary to manufacture CAR-T cells seems to directly correlate with quality: the longer the manufacturing time, the worse performance of CAR-T cells once infused into the patient. We hypothesize that platforms enabling in vivo engineering of CAR-T cells will enhance CAR-T cell quality and efficacy with less expense and greater patient access.

PI_NAMEs: BURDSALL, KYLIE A (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Ablation;Antibodies;B lymphoid malignancy;B-Cell Acute Lymphoblastic Leukemia;B-Cell Lymphomas;Binding;Biological;Biology;cancer type;CAR T cell therapy;CD19 gene;CD3 Antigens;Cell Physiology;Cells;Cellular biology;cellular transduction;chimeric antigen receptor;chimeric antigen receptor T cells;cost;cytokine;Cytokine Receptors;cytotoxicity;disorder control;dosage;engineered T cells;Engineering;Equilibrium;experimental study;Failure;Genetic Transcription;genome-wide;Glycoproteins;Human;Immunocompetent;immunodeficiency;Immunoglobulin Fragments;Immunology;Immunotherapy;In complete remission;In Vitro;in vivo;Information Systems;innovation;Institution;Knock-in;Lead;Lentivirus Vector;leukemia;Liquid substance;Low Density Lipoprotein Receptor;manufacture;manufacturing process;Mediating;medical schools;meetings;Melanoma;Membrane Glycoproteins;Membrane Proteins;Mentors;Mentorship;Methods;mouse model;multidisciplinary;Mus;Mutation;next generation;particle;Patients;Performance;Pharmaceutical Preparations;Phenotype;Physicians;Proliferating;Refractory;Relapse;Reporting;response;Route;Safety;Scientist;Site;Solid Neoplasm;standard care;Stomatitis;success;Surface;System;T cell differentiation;T-Cell Receptor Therapy;T-Lymphocyte;Testing;Therapeutic;Time;Toxic effect;transduction efficiency;translational therapeutics;tumor;Universities;Viral;virology;Virus;Work

PROJECT_TITLE: Biologic and Functional Characterization of In Vivo CAR-T cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (20)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: PROJECT NARRATIVE Mitochondria are central hubs of cellular metabolism, and have been implicated in genetic diseases affecting 1 in 5,000 people, as well as some of the most common diseases that contribute to human suffering such as cancer and heart failure. Targeting mitochondrial bioenergetics holds major therapeutic potential for these patients, and the mitochondrial acyl carrier protein is an attractive target that sits at a major intersection in mitochondrial bioenergetics. This proposal will define how the mitochondrial acyl carrier protein is regulated by upstream metabolism, providing information imperative to the development of future therapeutics controlling the mitochondrial acyl carrier protein to target mitochondrial dysfunction.

PI_NAMEs: WEDAN, RILEY  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: 4'-phosphopantetheine;Acetyl Coenzyme A;Acetyl-CoA Carboxylase;Acyl Carrier Protein;Acylation;Affect;Area;arm;Biochemistry;Bioenergetics;Biogenesis;Biology;Carbon;Cell Line;Cell Respiration;Cells;Cellular biology;Citric Acid Cycle;Clinical;cofactor;Collaborations;collaborative environment;college;Complex;Coupled;Cytoplasm;Data;Decarboxylation;Degree program;Development;Discipline;Disease;Disputes;Doctor of Philosophy;Electron Transport;Energy Metabolism;Enzyme Activation;Enzymes;experience;experimental study;Fatty Acids;Foundations;Functional disorder;Future;Generations;Genes;Genetic Diseases;Heart failure;holo-(acyl-carrier-protein) synthase;Human;in vivo;Inborn Errors of Metabolism;Insulin Resistance;Iron;Joints;Knock-out;Malignant Neoplasms;Malonates;Malonyl Coenzyme A;Mammalian Cell;Mammals;Mass Spectrum Analysis;Medicine;Mentorship;Metabolism;metabolomics;Methods;Michigan;Mitochondria;Mitochondrial Diseases;mitochondrial dysfunction;Mitochondrial Matrix;mitochondrial metabolism;Mitochondrial Proteins;mitochondrial therapeutics;Modeling;Modification;Molecular Biology;Mutation;novel;Nutrient;Nutrient availability;Nutritional;overexpression;Oxidative Phosphorylation;Pathway interactions;Patients;Persons;Play;Post-Translational Protein Processing;Process;Production;programs;protein activation;protein function;Protein Isoforms;Regulation;Reporting;Role;Scientist;skills;Source;stable isotope;Sulfur;Testing;Therapeutic;therapeutic target;Thioctic Acid;Training;Transferase;treatment strategy;Universities;Yeasts

PROJECT_TITLE: Upstream Requirements for the Regulation of Mitochondrial Bioenergetics by the Mitochondrial Acyl Carrier Protein

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular

ORG_CITY: Nashville

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Chronically activated, pro-inflammatory macrophages are believed to be critical determinants of disease progression in atherosclerosis. I have identified the immunomodulatory receptor Paired immunoglobulin-like receptor B (PirB) as a novel regulator of macrophage pro-inflammatory phenotype through its ability to regulate non-canonical autophagy and mitochondrial stress. Understanding the mechanism by which PirB coordinates these two crucial pathways to dampen inflammation may reveal new therapeutic targets to treat arterial inflammation.

PI_NAMEs: DUNGAN, MATTHEW M (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Anti-Inflammatory Agents;Apoptotic;Arterial Fatty Streak;Atherosclerosis;Automobile Driving;Autophagocytosis;Binding;Biological Assay;Blood Vessels;Cardiovascular Diseases;Cause of Death;cell type;Cells;Characteristics;Cholesterol;Chronic;chronic inflammatory disease;clinical risk;Clinical Trials;Complex;Confocal Microscopy;cytokine;Data;Digestion;Disease;Disease Progression;Elements;extracellular;Host Defense;Human;Immune;Immunofluorescence Immunologic;Immunoglobulins;immunoregulation;Impairment;In Vitro;Inflammasome;Inflammation;Inflammatory;inhibition of autophagy;inhibitor;Lesion;Ligation;Lipids;Lysosomes;Macrophage;magnetic beads;Mass Spectrum Analysis;Measurement;Measures;Mediating;member;Membrane Potentials;Metabolic;Metabolic dysfunction;Methods;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial membrane;Molecular;Morphology;mouse model;Mus;Myelogenous;Myeloid Cells;Necrosis;new therapeutic target;novel;Orthologous Gene;Oxidative Phosphorylation;pathogen;Pathway interactions;Phagocytosis;Phagosomes;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;PIK3CG gene;Plasmids;preservation;Process;Production;programs;Protein Tyrosine Kinase;Proteins;PTPN6 gene;Reactive Oxygen Species;receptor;recruit;Regulation;Reporter;Signal Pathway;Signal Transduction;STAT1 gene;Stimulus;Stress;Testing;Tissues;Transfection;uptake;vector;Western Blotting

PROJECT_TITLE: Loss of myeloid Paired Immunoglobulin-like Receptor B promotes atherosclerosis through inhibition of autophagy and metabolic rewiring

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-D (20)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative: Synapse specificity describes the process by which neurons must form the correct type of synapses with the correct synaptic partners. Results of this proposal will investigate the molecular mechanisms of how two synapse specificity molecules work together to mediate specific synapse formation. This basic research has clinical relevance because disruption of synapse specificity is thought to underlie many diseases, and mutations in one of the molecules I will study, Kirrel3, are associated with Autism spectrum disorders and intellectual disability.

PI_NAMEs: WEINBROM, ADAM  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Address;Adhesions;autism spectrum disorder;Basic Science;Binding;Binding Sites;Biological Assay;brain tissue;Cell Adhesion;Cell Adhesion Molecules;Cell Culture Techniques;Cell surface;Cell Surface Proteins;cell type;Cells;clinically relevant;Co-Immunoprecipitations;Complex;Cues;Cytoplasmic Granules;Data;dentate gyrus;Development;Disease;Electrophysiology (science);experimental study;extracellular;Filopodia;Foundations;gain of function;gamma-Aminobutyric Acid;Goals;Hippocampal Mossy Fibers;Hippocampus;human disease;Immunoglobulins;in vivo;Individual;Intellectual functioning disability;Intercellular Junctions;Interneurons;knock-down;Knock-out;Link;Mediating;member;Membrane;Membrane Proteins;Modeling;Molecular;mossy fiber;Mus;Mutation;Neurodevelopmental Disorder;Neuroglia;Neurons;Patients;Pattern;Phenotype;physical property;presynaptic;Presynaptic Terminals;Process;protein complex;protein expression;Protein Isoforms;protein protein interaction;Proteins;Proteomics;Risk Factors;Role;Sampling;Side;Signal Transduction;Specificity;Surface;Synapses;synaptic function;synaptogenesis;Testing;Variant;Work

PROJECT_TITLE: Mechanism and Synaptic Function of Binding Between Proteins Kirrel3 and IgSF8

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Nutrition;Obesity;Pneumonia and Influenza

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: PROJECT NARRATIVE This research aims to investigate the impact of obesity on natural killer (NK) cell function during influenza A virus (IAV) infection and its contribution to increased susceptibility and severity in obese individuals. By analyzing NK cell populations and their interaction with respiratory epithelial cells, the study seeks to uncover the underlying mechanisms that disrupt NK cell-epithelial cell crosstalk and potentially inform future interventions for respiratory infections in high-risk populations.

PI_NAMEs: BRIGLEB, PAMELA  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Affect;airway epithelium;Anti-viral Response;Blood;Body mass index;Body Weight decreased;c-myc Genes;career;career development;Cell Death;Cell Physiology;Cells;Characteristics;Coculture Techniques;Collaborations;collaborative environment;Color;Complex;cytokine;cytotoxicity;Data;design;Diabetes Mellitus;Disease;Environment;Epithelial Cells;Epithelium;Exhibits;experimental study;Flow Cytometry;Functional disorder;Future;GATA3 gene;Genomics;Goals;high risk population;Homeostasis;Human;Immune;Immunity;Impairment;improved;Individual;Infection;infection risk;Inflammation;inflammatory marker;Influenza;Influenza A virus;influenza infection;Innate Immune Response;insight;interdisciplinary approach;Interferon Type II;Interferons;Intervention;Knowledge;Laboratories;Lactate Dehydrogenase;Link;Lung;Malignant Neoplasms;Measures;Mediating;Metabolism;Metformin;Modeling;Morbidity - disease rate;mortality;Mucosal Immunity;mucosal site;Mucous Membrane;Nasal cavity;Nasal Lavage Fluid;Natural Immunity;Natural Killer Cells;Non-Insulin-Dependent Diabetes Mellitus;Obese Mice;obese person;Obesity;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phenotype;Plaque Assay;Plasma;Play;Population;Predisposition;Prevalence;Principal Investigator;Propidium Diiodide;Research;Research Personnel;Resources;Respiratory Tract Infections;response;Risk;RNA;Role;Saint Jude Children's Research Hospital;Sampling;Severities;Severity of illness;System;systemic inflammatory response;Techniques;Testing;Therapeutic Effect;Thinness;Training;transcription factor;transcriptomic profiling;transcriptomics;Viral;Virus Diseases;Virus Replication;Vulnerable Populations

PROJECT_TITLE: Impact of obesity on antiviral NK cell function and immune crosstalk with respiratory epithelial cells during influenza virus infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Genetics;Human Genome

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Climate change is the most significant event of our time, and will result in environmental pressures that will drive rapid organismal adaptation to novel environmental conditions, or in the absence of the capacity to adapt, extinction. I will study the Drosophila species on the tropical island of São Tomé to understand the relationship between underlying genetics and thermal tolerance and thermal preference. My work will illuminate the evolutionary mechanisms that permit organismal adaptations to a changing world.

PI_NAMEs: RADER, JONATHAN A. (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Africa;Animals;Automobile Driving;Backcrossings;Behavior;Behavioral;Biology;climate change;Communities;comparative;Coupled;Custom;Data;Data Set;design;Drosophila genus;Environment;environmental change;Event;Evolution;experience;experimental study;Exposure to;Extinction;fly;Future;Genetic;Genetic Determinism;Genetic Techniques;Genome;genome wide association study;Genomic approach;genomic data;High temperature of physical object;Individual;Invertebrates;Island;Laboratories;Link;Longitudinal Studies;Maps;Measures;Mentors;Methods;Movement;Natural History;Natural Selections;novel;Outcome;Output;Performance;Phenotype;Physiological;Physiology;Positioning Attribute;Predisposition;preference;pressure;Proxy;Quantitative Trait Loci;reproductive;Research;Role;Sister;systems research;Techniques;Temperature;Testing;Time;Training;training opportunity;trait;Work

PROJECT_TITLE: Evolution and underlying genetics of thermal physiology and behavior in Drosophila

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project narrative As incidences of digestive diseases continue to rise, there remains an urgent need to discover new therapeutic targets to alleviate the devastating effects of chronic colitis. Although the intestinal microbial composition is known to modulate gut health, the precise mechanism by which the gut microbiome influences host immunity to exacerbate chronic inflammatory bowel diseases remain largely unknown. In this application, we propose to study how the microbiome and circadian clock cooperate to enhance mucosal immunity and protect the host against colitis, thereby generating candidate targets that may ultimately aid in the design of new therapies.

PI_NAMEs: LIOU, MEGAN  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Biological;career;Cells;chemically induced colitis;Chronic;Chronobiology;circadian;circadian pacemaker;Circadian Rhythms;Colitis;Colon;Complex;Cues;design;dextran sulfate sodium induced colitis;Digestive System Disorders;Disease;Elements;Epithelial Cells;Epithelium;esterase;Exhibits;expectation;experimental study;Family member;Future;Gastrointestinal tract structure;Genes;Goals;Goblet Cells;gut health;gut inflammation;gut microbes;gut microbiome;gut microbiota;Health;host microbiota;host-microbe interactions;Human body;Immunity;Immunology;Incidence;Infectious colitis;Inflammatory Bowel Diseases;innovation;intestinal epithelium;intestinal homeostasis;Intestines;Knockout Mice;Large Intestine;Link;Maintenance;member;Methods;Microbe;microbial;microbial community;microbial composition;microbial homeostasis;microbiome;microbiome research;microbiota;Mucosal Immunity;Mucous body substance;Mucous Membrane;Mus;neurexophilin;new therapeutic target;novel;novel therapeutics;Organ;Pathway interactions;Periodicity;Permeability;Phenotype;Physiological;Play;Polysaccharides;Population;Predisposition;Production;Proteins;Recovery;Regulation;Research;Research Personnel;Role;Signal Transduction;Sorting;Surveys;Testing;Thinness;Time;Tissues;Training;transcriptome;transcriptome sequencing;transcriptomics;Wild Type Mouse;Work

PROJECT_TITLE: A new regulator of mucus production integrating temporal and microbial cues

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Genetic variants in the protein LOXL1 can alter individual risk for developing pseudoexfoliation glaucoma, a blinding disease that affects more than 10 million individuals worldwide. This project seeks to determine how these genetic variants alter the structure and function of LOXL1. Successful completion of this project will provide a better understanding of how LOXL1 variants contribute to pseudoexfoliation glaucoma and thereby provide important groundwork for therapeutic development.

PI_NAMEs: YOUNGBLOOD, HANNAH ABIGAIL (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Active Sites;ADAMTS;ADAMTS1 gene;Affect;Affinity;aggregation database;Amino Acids;Anterior eyeball segment structure;Aqueous Humor;Binding;Biochemical;Biomolecular Nuclear Magnetic Resonance;Blindness;C-terminal;Catalytic Domain;Code;cofactor;Copper;copper oxidase;crosslink;Deamination;Deposition;Disease;Elastin;Elastin Fiber;Etiology;FBLN5 gene;Fiber;fibulin 1;Future;Genetic;genetic variant;Genome;genome wide association study;Glaucoma;Goals;Individual;innovation;Ions;Link;Lysine;Mass Spectrum Analysis;Molecular;N-terminal;NMR Spectroscopy;Open-Angle Glaucoma;Peptide Signal Sequences;Physiologic Intraocular Pressure;prevent;Process;protective allele;Protein Family;protein structure;Protein-Lysine 6-Oxidase;Proteins;Proteolysis;Proteolytic Processing;retinal damage;Risk;risk variant;Scaffolding Protein;segregation;Site;Structure;Surface Plasmon Resonance;Testing;therapeutic development;Tropoelastin;Variant;variant of unknown significance;Western Blotting;X-Ray Crystallography

PROJECT_TITLE: The Structural and Biochemical Effects of XFG-Associated Variants in LOXL1

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Biomedical Imaging;Brain Disorders;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Depression;Emerging Infectious Diseases;Infectious Diseases;Mental Health;Mental Illness;Neurosciences;Pediatric;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative In the United States, SARS-CoV-2 has infected more than 16 million children and adolescents, who are undergoing critical periods of brain development and might be particularly susceptible to the neuroinflammation associated with COVID-19. However, the extent to which these inflammatory effects during the acute illness phase impact adolescent brain structure and function, and consequently cognitive abilities and risk for mental illness, remains unknown. A better understanding of these neurological effects will provide knowledge to identify adolescents most at risk for poor psychological health and cognitive deficits and the potential for early intervention through cognitive training or mental health therapy.

PI_NAMEs: RYAN, MEGHANN  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: 2019-nCoV;Acute;acute COVID-19;Address;Adolescence;Adolescent;Adolescent Psychiatry;Adult;Age;age group;age related;age related changes;Amygdaloid structure;Anisotropy;Anterior;Anxiety;anxiety symptoms;Area;Astrocytes;Autopsy;Axon;axon injury;Back;Behavioral;biological sex;Blood;Brain;brain abnormalities;brain health;Brain region;career;Cell Density;Cerebrospinal Fluid;Cerebrum;Child;Clinical;Clinical Research;Cognition;Cognitive;cognitive ability;cognitive control;Cognitive deficits;cognitive development;cognitive function;cognitive performance;cognitive testing;cognitive training;computerized data processing;COVID-19;COVID-19 impact;COVID-19 pandemic;critical period;Data;Data Analyses;data mining;Demyelinations;depressive symptoms;Detection;Development;Diffusion Magnetic Resonance Imaging;Early Intervention;Educational workshop;Emotional;Enrollment;executive function;Face;Female;Fiber;follow-up;Functional disorder;Functional Magnetic Resonance Imaging;glial activation;Glial Fibrillary Acidic Protein;gray matter;Hippocampus;Hospitalization;Image;Infection;Inflammatory;Knowledge;life span;Light;Magnetic Resonance Imaging;male;Maps;Measurement;Measures;Mediating;Mediation;Mental Depression;Mental disorders;Mental Health;Mentorship;Microglia;Mood Disorders;morphometry;mortality;Multimodal Imaging;Myelin;myelination;Nerve Degeneration;neurobehavioral;Neurobehavioral Manifestations;neurodevelopment;neurofilament;neuroimaging;neuroinflammation;Neurologic Effect;Neurons;nonhuman primate;Parents;Participant;Patients;Pattern;Performance;Phase;post SARS-CoV-2 infection;post-pandemic;Predisposition;Prevalence;psychiatric symptom;Puberty;Radial;Recording of previous events;Reporting;Research;Research Personnel;Risk;Rodent;Sample Size;SARS-CoV-2 infection;Schedule;Schizophrenia;sex;Sex Differences;Shapes;Short-Term Memory;Site;Structural defect;Structure;Surface;Swelling;symposium;synaptic pruning;Testing;Thick;Thinness;Training;United States;United States National Institutes of Health;Visit;water diffusion;white matter;white matter change;Youth

PROJECT_TITLE: Structural, Functional, and Neurobehavioral Consequences of Adolescent COVID-19

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE Ebola virus (EBOV) and Marburg virus (MARV) cause fulminant disease in humans with alarmingly high fatality rates. Given the prevalence of gastrointestinal symptoms associated with Ebola virus diseases (EVD) and Marburg virus disease (MVD) presentation, the study of EBOV and MARV infection in intestinal cells is of clear clinical relevance and importance. The goal of this proposal is to study the mechanisms by which EBOV and MARV infections cause gastrointestinal manifestations, particularly intestinal diarrhea, using novel infection platforms based on induced pluripotent stem cells (iPSC)-derived human intestinal organoids and their ability to recapitulate intestinal filovirus infection.

PI_NAMEs: FLORES, ELIZABETH YVONNE (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: 3-Dimensional;Abdominal Pain;Ablation;Affect;Africa;Animal Model;Architecture;associated symptom;Body Fluids;Case Fatality Rates;CDX2 gene;Cell Culture System;Cell Death;Cell model;Cell Physiology;Cells;Cessation of life;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Colon;Data;Development;Diarrhea;differentiation protocol;Disease;Disease Outbreaks;Disease Progression;Distal;drug candidate;Ebola Hemorrhagic Fever;Ebola virus;Educational workshop;Emergency Situation;epithelial injury;Epithelium;Exhibits;Family;Fatality rate;Filoviridae Infections;Filovirus;Functional disorder;gastrointestinal;gastrointestinal symptom;Generations;Genes;Genetic;Goals;Hemorrhage;Heterogeneity;Hindgut;Human;human induced pluripotent stem cells;improved;in vivo;Individual;induced pluripotent stem cell;Infection;Injury;Intercellular Junctions;intestinal barrier;intestinal epithelium;Intestines;Investigation;Ions;Knowledge;lectures;Life;Liquid substance;Marburg Virus Disease;Marburgvirus;Mediating;Mentorship;Modeling;Molecular;Mucous Membrane;new therapeutic target;nonhuman primate;novel;Organoids;Pathway interactions;Patients;Penetrance;permissiveness;Phenotype;Physiological;Prevalence;progenitor;Proteins;receptor;Reporter;Reporting;research facility;RNA Viruses;Role;Science;Sepsis;Series;single-cell RNA sequencing;Small Intestines;small molecule inhibitor;Symptoms;Syndrome;System;Testing;Therapeutic;Therapeutic Intervention;Therapeutic Monoclonal Antibodies;Tight Junctions;Tissues;tool;Training;Training Programs;transcriptomics;transmission process;Vaccines;villin;Viral;viral outbreak;Viral Pathogenesis;Virus;Virus Diseases;Vomiting;Work;Writing;Zoonoses

PROJECT_TITLE: An iPSC-derived human organoid based model of intestinal filovirus infection


NIH_SPENDING_CATS: Cancer;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_CITY: Chicago

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Androgens are a known driver of aggressive prostate cancer, and our findings support that vitamin D deficiency leads to elevated androgens in the prostate tissue of African American men. We further identified megalin as an endocytic receptor expressed in the prostate, regulated by vitamin D, as importing circulating testosterone. Here we propose to examine vitamin D deficiency and megalin in aggressive prostate cancer and the consequences of vitamin D deficiency on prostate hormone homeostasis in patient-derived models, patient specimens, and mouse models.

PI_NAMEs: NONN, LARISA  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: absorption;Advanced Malignant Neoplasm;Affect;African American;African American population;African ancestry;Androgen Antagonists;androgen independent prostate cancer;Androgens;Animals;Binding;bone health;cancer health disparity;Cancer Patient;Cells;Chemopreventive Agent;Clinical;clinically relevant;clinically significant;cohort;Cutaneous;Data;Dependence;Diagnosis;Diet;Disease;Disparity;Dose;epidemiology study;Exposure to;Feedback;General Practitioners;Globulins;Goals;Homeostasis;Hormonal;hormone binding protein;hormone regulation;Hormones;improved;in vivo;insight;Knockout Mice;LDL-Receptor Related Protein 2;Lead;Link;Localized Disease;male;Malignant neoplasm of prostate;Mediating;Melanins;men;Modeling;mouse model;Mus;Needles;Neoplasm Metastasis;Neuroendocrine Prostate Cancer;Organoids;Patients;Phenotype;Physicians;prevent;Prostate;prostate cancer progression;prostate cancer risk;Prostatic;Proteins;Publications;receptor;Regulation;Risk;Sampling;screening;Serum;skeletal;Specimen;Stanolone;sunlight-induced;Testing;Testosterone;Tissue Microarray;Tissues;Ultraviolet Rays;Vitamin D;Vitamin D Deficiency;Work

PROJECT_TITLE: Men of African Ancestry are primed for aggressive prostate cancer by high prostate androgens driven by vitamin D deficiency and megalin

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Despite the clear benefits of medications for opioid use disorder (MOUD) for people with HIV and OUD, little is known about which specific form of MOUD is more beneficial to brain health in people with HIV. We will assess for measures of improved brain health (cognition and brain fluid inflammation) in people with HIV on different forms of MOUD.

PI_NAMEs: CORLEY, MICHAEL JAY;FARHADIAN, SHELLI  (contact);SPRINGER, SANDRA ANN

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Abnormal Myeloid Cell;Accounting;addiction;Address;Affect;Aftercare;Agonist;alcohol use disorder;American;Anti-Inflammatory Agents;Automobile Driving;Biological;Biological Markers;Brain;brain health;Buprenorphine;cell type;Cells;Central Nervous System;Cerebrospinal Fluid;Cessation of life;Chromatin;Cicatrix;Clinical;Cognition;Cognitive;cognitive function;cognitive performance;cognitive testing;Communities;Congenital neurologic anomalies;cytokine;Data;Data Science;Diagnosis;Disease;Disease associated microglia;DSM-V;effective therapy;Enrollment;Epigenetic Process;epigenetic profiling;epigenome;Exhibits;Fentanyl;fentanyl analog;Gene Expression;gene network;Genes;Genetic Transcription;glial activation;Goals;Health system;HIV;Immune;immune activation;Immune system;Impaired cognition;improved;Inflammation;Inflammatory;Infrastructure;innovation;Knowledge;Lead;lens;Link;Liquid substance;Machine Learning;manufacture;Measures;Mediator;medication for opioid use disorder;Medicine;meetings;Methadone;Microglia;mobile health clinic;Molecular;multidisciplinary;multiple omics;Myelogenous;Myeloid Cell Activation;Myeloid Cells;Naltrexone;neuroAIDS;Neurocognition;Neuroimmune;Neuroimmune system;neuroinflammation;Neuronal Injury;Neuropsychology;Nucleic Acid Regulatory Sequences;Opioid;Opioid agonist;Opioid Antagonist;Opioid Receptor;opioid use disorder;overdose death;Participant;Patient Care;Patient Recruitments;Persons;Pharmaceutical Preparations;Population;preclinical study;programs;Public Health;Publishing;Regimen;Repression;Research;Resolution;response;Role;Signal Transduction;single cell genomics;Spinal Puncture;synthetic opioid;Testing;Time;transcriptomics;treatment and outcome;Viral;Virus Replication;Work

PROJECT_TITLE: Effects of Medication for Opioid Use Disorder on Microglial Activation and Neurocognition in People Living with HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 TXT-E (J2)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lead Poisoning;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Lead (Pb) is an important public health threat, and exposure to Pb has been shown to increase the risk of adverse pregnancy outcomes among African Americans, who also experience the detrimental health impacts of racial and gender discrimination. Racial health disparities in maternal mortality and morbidity persist across socioeconomic strata and extent of educational attainment; thus, a more robust understanding of root-causes of maternal health disparities are essential to improving health outcomes for women in minoritized racial groups. Through providing insight into the impact of Pb on preterm birth – specifically in the context of structural racism – this study will create actionable solutions that can be directly applied to patient care through community engagement.

PI_NAMEs: EATMAN, JASMIN AFRICALI (contact)

PROJECT_TERMS: 37 weeks gestation;Acute;adverse birth outcomes;adverse pregnancy outcome;Affect;African American;African American population;African American Women;Area;Awareness;Back;bioaccumulation;Biological;Biological Monitoring;Birth;Birth Weight;Black Populations;Blood;blood lead;blood Pb concentration;Blood specimen;bone;Centers for Disease Control and Prevention (U.S.);Characteristics;Chemicals;Child;cohort;Communication;Communities;community academic partnership;community engaged research;community engagement;Complex;Data;design;Discrimination;Disparity;Education;Enrollment;Environment;Environmental Hazards;Environmental Health;epidemiology study;Evaluation;experience;Exposure to;Feedback;Fetal Development;Focus Groups;Frequencies;Gender;Generations;Health;health disparity;health equity;health inequalities;Health Insurance;health literacy;high risk;Home;Housing;Human;improved;Individual;infant morbidity;infant morbidity/mortality;innovation;insight;Interruption;Intervention;Joints;Knowledge;Laboratory Finding;Lead;lead exposure;Lead levels;Learning;Low income;low socioeconomic status;marginalized population;Maternal Health;maternal morbidity;Maternal Mortality;Measurement;Measures;Metals;Minority;National Health and Nutrition Examination Survey;Neighborhoods;Outcome;Participant;Patient Care;Patient Self-Report;Pattern;perceived discrimination;Perinatal;perinatal health;perinatal period;Persons;Phenotype;phthalates;Placenta;Play;Population;Pregnancy;pregnant;Pregnant Women;Premature Birth;prenatal;prenatal exposure;prospective;Psychological Stress;Psychosocial Stress;Public Health;Race;racial discrimination;racial disparity;racial health disparity;racial minority population;racial population;Racial Segregation;racism;Reporting;Research;Research Personnel;Risk;Risk Factors;risk mitigation;Rodent Model;segregation;Sex Discrimination;social determinants;Social Environment;social stress;Socioeconomic Status;socioeconomics;Stress;stressor;structural determinants;Structural Racism;Surveys;Testing;tool;Toxic Environmental Substances;toxic metal;Toxicant exposure;United States;United States National Institutes of Health;White Women;Whole Blood;women's outcomes;Work

PROJECT_TITLE: Investigating Determinants of Perinatal Lead Exposure, Associations with Preterm Birth, and Reporting Back Research Results in the Atlanta African American Maternal Child Cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative: Huntington’s disease (HD) is an inherited, neurodegenerative disorder that debilitates individuals due to uncontrolled movement, changes in personality and loss of cognition. Astrocytes, the guardians of the brain, survey and nourish brain cells and have received growing attention due to their involvement in neurodegenerative pathologies. Research proposed here on HD astrocytes during development and disease progression is imperative to the field to inform efficient disease modifying therapies.

PI_NAMEs: BURNS, MARA  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: activating transcription factor 3;Address;Adult;Antioxidants;Astrocytes;Attention;Automobile Driving;Back;Basal Ganglia;Bioinformatics;bioinformatics tool;Biological Assay;Blood - brain barrier anatomy;Brain;brain cell;CAG repeat;Cell Communication;Cell Maturation;Cell model;Cell Nucleus;Cell Physiology;cell type;Cells;cerebral atrophy;Cognition;Communication;Communities;Corpus striatum structure;Data;Data Analyses;data integration;Data Set;Dependence;Development;Developmental Gene;Developmental Process;Disease;Disease Progression;Disease susceptibility;Down-Regulation;driving force;Environment;Exons;functional improvement;functional outcomes;Gene Proteins;Genes;Genetic;Genetic Transcription;GLAST Protein;Glutamates;Growth;Heterogeneity;Homeostasis;human disease;Huntington Disease;Huntington gene;IGF1 gene;Impairment;improved;In Vitro;Individual;induced pluripotent stem cell;Inherited;innovation;insight;interest;Investigation;Ions;knock-down;Knowledge;Laboratories;Life;Ligands;Literature;Maps;Mentorship;Messenger RNA;mitochondrial metabolism;Molecular;Morphology;mouse model;Movement;Mus;mutant;Mutate;Nerve Degeneration;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Deficit;Neurons;neuropathology;neurotransmitter metabolism;Neurotransmitters;novel;Outcome Measure;overexpression;Paint;Pathologic;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Personal Satisfaction;Personality;Phenotype;polyglutamine;postnatal;Predisposition;Process;Proteins;receptor;Regional Disease;Research;Resolution;Resources;response;RNA;Role;Scientist;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;skills;spatial integration;Statistical Models;Stress;stressor;Surveys;TCF7L2 gene;Testing;Therapeutic Intervention;therapeutic target;Time;Tissues;transcription factor;transcriptomics;translational approach;uptake;Work

PROJECT_TITLE: Effect of mutant HTT on the development and maturation of astrocytes


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Narrative How apicomplexan parasites control highly divergent cell division is not well understood, but it is clear that the proper execution of the cell cycle program is critical to parasite numbers in the host and associated disease. In this proposal, we will investigate the molecular basis for cell cycle control in Toxoplasma gondii. Some of the essential factors identified in our studies are shared by other related pathogens, such as Plasmodium falciparum, which causes malaria and, therefore, has a broader impact on the field of studies.

PI_NAMEs: SUVOROVA, ELENA  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Apicomplexa;asexual;Biological Process;Biology;burden of illness;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell division;Cells;Centrosome;Cesarean section;Cessation of life;chromosome replication;Chromosome Segregation;Chromosomes;Communicable Diseases;Complex;Coupled;Cryptosporidium;Cyclins;daughter cell;design;Disease;Event;event cycle;experimental study;field study;flexibility;Foundations;G1 Phase;G2 Phase;G2/M Transition;Genome;Human;human disease;human pathogen;infancy;Infection;innovation;insight;Link;Malaria;Mitosis;Mitotic;Modeling;Molecular;novel;Nuclear;nuclear division;Outcome;Parasite Control;Parasites;pathogen;Pathogenesis;Pathway interactions;Phase;Phase Transition;Phosphorylation;Phosphotransferases;Plasmodium;Plasmodium falciparum;Population;Process;programs;Protein Analysis;protein expression;Proteins;Proteomics;Quantitative Microscopy;Regulation;Repression;segregation;Severities;Structure;Structure of thyroid parafollicular cell;Testing;tool;Toxoplasma gondii;Work

PROJECT_TITLE: Regulation of apicomplexan mitosis coupled to budding

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-X (02)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

ORG_STATE: TX

PHR: Narrative: The sense of taste plays a vital role in our survival, enabling us to discern nutrients and toxins in our surroundings. Chemotherapy-induced taste dysfunction can lead to malnutrition and a reduced quality of life, underscoring the urgency of comprehending its causes and finding effective remedies for these adverse effects. This proposal aims to investigate the impact of a common chemotherapeutic, cyclophosphamide, on gustatory neurons to shed light on the underlying mechanisms of chemotherapy-induced taste dysfunction.

PI_NAMEs: WOOD, RYAN  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Address;Adult;Adverse effects;Affect;Aftercare;Ageusia;Calcium;career;career development;chemotherapy;chorda tympani;Communication;Cyclophosphamide;Data;design;Detection;Electrophysiology (science);experience;Fiber;Functional disorder;Goals;Human;Image;Immunohistochemistry;improved;in vivo calcium imaging;Individual;intravital imaging;intravital microscopy;Investigation;Label;Link;Malnutrition;Measures;Mentors;Monitor;mouse model;Mus;Nerve;nerve supply;Neuroimmune;Neurons;neurotransmission;Nutrient;partial recovery;Patients;Peripheral;Personal Satisfaction;Play;Population;presynaptic;Process;Quality of life;Receptor Cell;Recovery;reinnervation;Reporting;response;Role;sensory system;Signal Induction;Signal Transduction;skills;Specificity;Stimulus;Structure;Structure of geniculate ganglion;Synapses;Taste Buds;Taste Perception;taste stimuli;taste system;Techniques;Therapeutic;Time;time use;timeline;Toxin;Training;two-photon;Visualization

PROJECT_TITLE: Investigating alterations in gustatory neuron innervation and function over the course of chemotherapy treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (12)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Contraception/Reproduction;Maternal Health;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE Long-acting reversible contraceptives (LARCs) are often promoted in low- and middle-income countries, yet qualitative studies suggest that LARC promotion can inhibit reproductive autonomy through overzealous encouragement for uptake and barriers to removal, thereby impacting public health and human rights. This mixed-methods study will use secondary data collected as part of the Postpartum Intrauterine Device (IUD) Study in Tanzania and Nepal to examine if and how a postpartum IUD intervention impacted women’s experiences with autonomy in contraceptive decision-making and IUD discontinuation. The proposed aims align with NICHD’s strategic goal of “setting the foundation for healthy pregnancies and lifelong wellness” and can be used to inform future family planning programs that aim to increase contraceptive access and support reproductive autonomy.

PI_NAMEs: BULLINGTON, BROOKE WHITNEY (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Adopted;Affect;Bioethics;Caring;Child;Cluster randomized trial;Coercion;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Counseling;Data;Decision Making;Development;Device Removal;diverse data;doctoral student;empowerment;Enrollment;Ensure;Environment;Epidemiology;evidence base;Excision;experience;Face;Family Planning;Family Planning Programs;Fees;Fellowship;follow-up;Foundations;Funding;Future;Goals;Health;Health care facility;Health Promotion;healthy pregnancy;Human Rights;Individual;Intervention;Interview;Intrauterine Devices;Knowledge;Logistic Regressions;low and middle-income countries;Low Birth Weight Infant;Marital Status;Maternal and Child Health;Measures;Medical;Medicine;Mental Depression;Mentorship;Methodology;Methods;National Institute of Child Health and Human Development;Nepal;North Carolina;novel;Outcome;parity;Participant;Pattern;person centered;Population;Population Sciences;Positioning Attribute;postpartum care;Postpartum Period;pre-doctoral;pressure;programs;Provider;Public Health;Randomized;Recommendation;Reporting;reproductive;reproductive epidemiology;Research;Research Personnel;Resources;reversible contraceptive;Services;skills;Social Sciences;sociodemographic factors;standard of care;Surveys;Survival Analysis;Tanzania;Techniques;therapy design;Time;Training;Training Programs;unintended pregnancy;Universities;uptake;Woman;Women's Health;Writing

PROJECT_TITLE: Assessing the impact of a postpartum intrauterine device intervention on contraceptive decision-making

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE The cardiovascular system is vital for the growth and healing of wounds, playing a crucial role in overall well- being. This proposal utilizes a multidisciplinary approach to investigate the activation mechanism and modulation of the Tie2 receptor, an essential membrane protein responsible for creating tight cell-cell junctions at the endothelial monolayer that lines the blood vessels. The results of this study will provide a more complete picture of the regulation of Tie2 on the structural level to improve our understanding of Tie2 biology and provide a platform to investigate the dysregulation of Tie2 in human vasculature diseases.

PI_NAMEs: NGUYEN, ADAM  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Affect;angiogenesis;Angiopoietins;ANGPT1 gene;Architecture;Basic Science;Binding;Binding Proteins;Binding Sites;Biological Assay;Biology;Biophysics;Blood Vessels;Cardiovascular system;Cell Adhesion;Cell membrane;cell motility;Cell surface;Cells;Cellular biology;Communication;Cryoelectron Microscopy;Development;Dimerization;Disease;Distant;Embryo;Endothelial Cells;Endothelium;Ensure;Event;Experimental Designs;experimental study;Fibronectins;field study;Fluorescence Resonance Energy Transfer;Foundations;Goals;Growth;Health;Homeostasis;Human;improved;insight;Integrin alpha5beta1;Integrins;Intercellular Junctions;interdisciplinary approach;Investigation;Length;Ligand Binding;Ligands;malformation;Malignant Neoplasms;Mediating;Medicine;Membrane;Membrane Proteins;Methods;Modeling;Molecular;monolayer;Motility;Multicellular Process;new therapeutic target;Nutrient;Organ;Pathway interactions;Personal Satisfaction;Phosphorylation;Play;Process;Proliferating;Property;Proteins;receptor;Receptor Cross-Talk;receptor function;Receptor Protein-Tyrosine Kinases;Regulation;Research;Resolution;Role;Signal Pathway;Signal Transduction;Site;stem;structural biology;Structure;System;Techniques;Technology;Testing;TIE-2 Receptor;Travel;wound healing

PROJECT_TITLE: Structural Mechanism of Activation and Modulation of Tie2-mediated Angiogenesis


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Cancer;Complementary and Integrative Health;Genetics;Infectious Diseases;Microbiome;Natural Products

ORG_CITY: CORVALLIS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Estuaries are dynamic interfaces between the marine and terrestrial environments and estuarine sediments support a tremendous diversity of microorganisms which interact by expression of chemical signals or natural products. Microbial natural products have been valuable sources of therapeutic agents, and there remains a need for new biologically active compounds to study and treat drug-resistant cancers and infectious diseases. The use of in situ sampling methods paired with advanced mass spectrometric analysis will facilitate an unprecedented metabolomic study of estuarine sediment communities and identification of biologically active natural products with potential for human disease treatment and management.

PI_NAMEs: REDICK, MARGARET  (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: 16S ribosomal RNA sequencing;Adsorption;Affinity;Anabolism;Anti-Bacterial Agents;anti-cancer;antimicrobial;Area;Bacteria;Bacterial Genome;Bacterial Infections;Beds;Binding;bioactive natural products;Biological;Biological Assay;Biological Testing;Cancerous;Cell Line;Cell Surface Receptors;Cells;Chemicals;cheminformatics;Chronic Disease;combat;Communicable Diseases;Communication;Communities;Complex;Complex Mixtures;computerized tools;Computing Methodologies;Cues;Culture Media;cytotoxic;Data;Detection;Drug resistance;druggable target;Ecosystem;Endoplasmic Reticulum;endoplasmic reticulum stress;Environment;Future;Gene Cluster;Generations;Goals;GRP78 gene;harmful algal blooms;human disease;In Situ;Infection;infectious disease treatment;inhibitor;interest;Investigation;Laboratories;Laboratory culture;Ligands;Link;Magnetism;Malignant Neoplasms;Mammalian Cell;marine;Marine Sediment;Mass Spectrum Analysis;Mediating;metabolome;metabolomics;Metagenomics;Methods;microbial;microbial community;Microbial natural product;microbiome;microorganism;Microspheres;Mining;Molecular Chaperones;Monitor;Natural Products;Neoplasm Metastasis;Normal Cell;novel;Oregon;Organism;overexpression;pathogenic bacteria;pathogenic fungus;Pathway interactions;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phylogenetic Analysis;Plant Resins;Play;polypeptide;Production;protein complex;protein folding;Proteins;proteostasis;refractory cancer;Research;Resolution;Ribosomal RNA;Role;Sampling;screening;secretory protein;Signal Transduction;Site;Solid;solvent extraction;Source;Structure;Techniques;Testing;Therapeutic Agents;tool;Toxin;trend;Variant;Viral;Virus Diseases

PROJECT_TITLE: Integrated metabolomic and microbial community analysis of estuarine sediments and their potential as sources of bioactive natural products

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (04)]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Diabetes;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative More than 37 million people in the United States have diabetes. Despite many medications for diabetes, the number of deaths resulting from coronary vascular complications, including coronary microvascular disease, is still high among patients with diabetes. This study is designed to identify the cellular defects that cause the abnormalities of small coronary arteries in diabetic patients and to develop new therapeutic approaches for coronary endothelial dysfunction in diabetes.

PI_NAMEs: LEE, YUN SOK ;MAKINO, AYAKO  (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: angiogenesis;Anti-Inflammatory Agents;Apoptosis;Apoptotic;Arteries;arteriole;Atherosclerosis;Attenuated;Blood capillaries;Blood flow;Blood Vessels;Cardiac;Cardiomyopathies;Cardiovascular Diseases;Cell Separation;Cell-Cell Adhesion;Cells;Cessation of life;Chronic;Compensation;Contracts;Coronary;Coronary Arteriosclerosis;Coronary artery;Coronary Vessel Anomalies;Data;Defect;density;design;Development;Diabetes Mellitus;diabetic;diabetic cardiomyopathy;Diabetic mouse;diabetic patient;Distal;Down-Regulation;Endothelial Cells;endothelial dysfunction;Endothelium;Epidemic;Epidermal Growth Factor;Exhibits;Functional disorder;Glycoproteins;Goals;Heart;Heart Diseases;Heart Hypertrophy;Immunosuppressive Agents;improved;Incidence;Inflammation;Inflammatory;Injury;insight;Investigation;Lead;Left ventricular structure;Lipids;Macrophage;Mediating;Microvascular Dysfunction;migration;milk fat globule;Mitochondrial DNA;Molecular;mortality;Mus;Myocardial Ischemia;novel;novel therapeutic intervention;novel therapeutics;Patients;Persons;Phagocytes;Pharmaceutical Preparations;Phenotype;Play;Population;programs;Relaxation;Reporting;Risk Factors;Role;Splenomegaly;Stenosis;Stroke;Testing;Therapeutic Intervention;therapeutically effective;tissue injury;tissue regeneration;tissue repair;Tissues;Treatment Factor;United States;Vascular Endothelial Growth Factors;Vascular Endothelium-Dependent Relaxation;Vascular remodeling;vasoconstriction;Vasodilation

PROJECT_TITLE: Coronary Endothelial Cell Dysfunction in Diabetes: Role of MFGE8

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative The goal of this study is to investigate the culturally-specific storytelling practices and styles of bilingual Latinx children with and without Developmental Language Disorder (DLD). We will document the storytelling practices and styles bilingual children with DLD participate in at home and in their communities. Lastly, we will compare their performance on narratives using extant White, Educated, Industrialized, Rich, and Democratic (WEIRD) measures with culturally-relevant measures that arise from the data, so that speech-language pathologists may optimize assessment for this historically underserved population.

PI_NAMEs: GRANADOS VARGAS, ALEJANDRO  (contact)

PROJECT_TERMS: Adult;Affect;Anecdotes;Assessment tool;Awareness;bilingualism;California;Child;Child Language;Childhood;Communities;Community Practice;Complex;cultural competence;Data;data collection site;design;disability;Disabled Children;Disease;Documentation;Educational Curriculum;Elements;Ethnography;Evaluation;Event;experience;Exposure to;Family;Family Relationship;Fellowship;Goals;health disparity;Home;Impairment;Industrialization;Intervention;Interview;Language;Language Development Disorders;Latinx;Learning;Learning Difficulty;Linguistics;Measures;Mentorship;Methods;Mexican;Mexican Americans;minority children;minority communities;novel;Oral;Outcome;Pathologist;Performance;Process;Psychometrics;public education;Qualitative Research;Reaction;Reading;Reduce health disparities;Research;Research Methodology;Research Personnel;Role;Sampling;Schools;Services;skills;Special Education;Speech;Structure;Surveys;syntax;System;Time;tool;Training;training opportunity;Underserved Population;United States;Vocabulary;Washington;Work;Youth

PROJECT_TITLE: Documenting the Home and Community Storytelling Practices of Mexican-American Bilingual Children with Developmental Language Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (32)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Cardiovascular;Lung;Sleep Research

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Narrative Accurately assessing obstructive sleep apnea (OSA) severity is essential to improving patient care. In this proposal, we will develop a mathematical model to provide a detailed clinical representation of OSA at various target locations in the body, which will allow for the assessment of tissue hypoxia burden and daytime sleepiness as a potential alternative indicator of severity and serve as an important step in my training in clinically-relevant computational research.The clinically deployable model and resulting pool of data, which will be obtained from simulated cases of OSA and a re-analysis of existing polysomnography studies, will be invaluable to furthering the clinical understanding of OSA.

PI_NAMEs: QAYYUM, NIDA TARIQ (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Address;Affect;aging population;Alveolar;Apnea;Assessment tool;Blood gas;Brain;Breathing;Carbon Dioxide;Cardiovascular Diseases;cardiovascular effects;career;Characteristics;Clinical;clinical application;Clinical Data;Clinical Research;clinically relevant;Cyclosporine;Data;Data Pooling;Data Set;Databases;Development;Diagnosis;Dimensions;Disease;Drowsiness;Equation;Evaluation;Health;Heart;Heart Rate;Hemoglobin;Hypercapnia;Hypertension;Hypoxia;Impaired cognition;improved;indexing;Link;Literature;Location;lung volume;mathematical model;Measurement;Measures;meter;Methods;middle age;Modeling;Movement;Obstructive Sleep Apnea;Outcome;Output;Oxygen;oxygen transport;Patient Care;Patients;Pattern;Physiological;Play;Polysomnography;primary outcome;Property;Pulmonary alveolar structure;Pulse Oximetry;Recording of previous events;Research;respiratory;Rest;Risk Assessment;Role;Running;Severities;Sleep;Sleep Apnea Syndromes;Structure;Testing;Time;tissue oxygenation;Tissues;tool;Training;Validation;Venous;Work

PROJECT_TITLE: Developing tools for assessing obstructive sleep apnea severity and consequences from existing clinical data


NIH_SPENDING_CATS: Cancer

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Quiescent cancer cells are a source of drug resistance as they evade chemotherapeutic treatments targeted at cycling cells and retain their ability to proliferate in the future, whereas senescent cancer cells are tumor- suppressive as they limit the proliferation of damaged cells and recruit the immune system. The proposed research will investigate how cells transit between quiescence and senescence and will determine the mechanism by which quiescent cells permanently lose their ability to proliferate, thus becoming senescent. Quiescent and senescent cells arise side-by-side following chemotherapeutic treatment, thus, a mechanistic understanding of how cells choose between these fates would aid in the development of more targeted and effective chemotherapy treatments.

PI_NAMEs: FERNANDEZ, BRIANNA  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: acute stress;Address;Aging;Automobile Driving;Biological Assay;Biological Markers;Biosensor;cancer cell;Cell Cycle;cell injury;Cells;Cellular Assay;Characteristics;chemotherapy;Chemotherapy-Oncologic Procedure;Clustered Regularly Interspaced Short Palindromic Repeats;Cyclin D1;Data;Development;Diagnosis;Disease;Drug resistance;Equilibrium;experimental study;Flow Cytometry;Future;genetic signature;Image;Immune system;Immunofluorescence Immunologic;Inflammatory;knock-down;Knowledge;Malignant Neoplasms;Measures;Mediating;Methods;Microscopy;Molecular;neoplastic cell;Outcome;overexpression;Phenotype;Population;Probability;Proliferating;Proteins;Publishing;recruit;Reporter;Research;senescence;senescent cell;sensor;Side;Signal Transduction;Source;Stains;Stress;Testing;Therapeutic;Time;transcriptome;transcriptome sequencing;Treatment Efficacy;Tumor Suppressor Proteins;Withdrawal;Work

PROJECT_TITLE: Defining the transition from deep quiescence to senescence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: SYRACUSE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative  The assembly and disassembly of CTD-mediated transcription factory and the molecular interactions that regulate this process are poorly understood. Dysregulation of transcription is associated with cancer, diabetes, obesity, autoimmunity, neurological disorders, and cardiovascular diseases. In this proposal, I will focus on two regulators of transcription; phosphorylation of CTD from fungi living in extreme environment and their cis-trans prolyl isomerization by the PPIase Ess1, and how these modifications influence the LLPS of the CTD in vitro and at the atomic level.

PI_NAMEs: MCKEAN, NATHAN H. (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Adopted;Amino Acid Sequence;Amino Acids;Autoimmunity;Behavior;Binding;Biological;Biological Assay;Candida albicans;Cardiovascular Diseases;Catalysis;Cell Nucleus;cis trans isomerization;cold temperature;Complex;Consensus;Data;Detection;Diabetes Mellitus;Disease;DNA;Elements;Environment;Enzymes;Evolution;Eye;Fission Yeast;fungus;Gene Expression;Genetic Transcription;Geography;Goals;Grant;Holoenzymes;Human;In Vitro;Individual;Interference Microscopy;Isomerism;light scattering;Liquid substance;Location;Malignant Neoplasms;Mediating;Membrane;model organism;Modification;Molecular;Molecular Biology;Molecular Conformation;mutant;Nervous System Disorder;NMR Spectroscopy;Obesity;Organelles;Organism;Orthologous Gene;Outcome;Pathway interactions;Peptidylprolyl Isomerase;Phase;Phosphorylation;Physical condensation;Physiologic pulse;Play;polar environment;Polar Regions;Positioning Attribute;Process;programs;Property;recruit;Regulation;response;RNA chemical synthesis;RNA Polymerase II;RNA Splicing;Role;Saccharomyces cerevisiae;Series;seryl-proline;Sodium Chloride;spatiotemporal;Spectrum Analysis;Stress;Structure;Syndrome;Temperature;Testing;therapeutic target;Transcription Process;Transcriptional Regulation;Yeasts

PROJECT_TITLE: Investigating the mechanism of Ess1-mediated regulation of the CTD of RNAP II phase separation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Genetics;Prevention;Skin Cancer

ORG_NAME: UNIVERSITY OF UTAH

PHR: Project Narrative Sunscreens that prevent UVR induced DNA damage are imperative for human health and protection against melanoma. This project will investigate the function of gadusol, a newly discovered vertebrate sunscreen. Our study will provide insight into the developmental mechanisms and evolutionary origin of this sunscreen, which could lead to the production of effective and environmentally safe sunscreens.

PI_NAMEs: JOHNSON, KRISTIN LORETTE (contact)

PROJECT_TERMS: absorption;Adolescent;Adult;Algae;Animals;Biological Assay;cell type;Cells;Communities;Dangerousness;Data;Deposition;Development;DNA;DNA Damage;Dorsal;Dose;egg;Embryo;Embryonic Development;Environment;Enzymes;Event;Evolution;experimental study;Exposure to;Fishes;Food Webs;Future;gene synthesis;Genes;genetic approach;Genome;Health;Heart;Horizontal Gene Transfer;Human;improved;insight;Learning;Life;Light;Liver;Malignant Neoplasms;Melanins;Melanoma;Melanophores;metabolomics;microbial;mutant;Names;novel;Organ;Organelles;Organism;Ovary;Ozone;Penetration;Photons;Pigments;Planet Earth;Population;prevent;Production;Radiation induced damage;Radiation Induced DNA Damage;radiation response;Regulatory Element;Research;Research Personnel;Research Project Grants;Resistance;response;Role;Sequence Homology;single-cell RNA sequencing;skills;Skin;Source;Stomach;Sunlight;Sunscreening Agents;Techniques;Tissues;Transcript;Ultraviolet A radiation;Ultraviolet B Radiation;ultraviolet damage;Ultraviolet Rays;Universities;Utah;UV induced;UV protection;UV Radiation Exposure;Vertebrates;Water;Zebrafish

PROJECT_TITLE: Gadusol: An ancient sunscreen that protects metazoan development


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Chronic Pain;Dental, Oral, and Craniofacial Disease;Genetics;Pain Research;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: Los Angeles

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Disorders of the temporomandibular joint of the jaw are a common source of chronic pain. This proposal uses complementary zebrafish and mouse models to investigate the role of LGRs, which potentiate Wnt signaling, in maintaining and controlling differentiation of stem cells that give rise to diverse jaw joint connective tissues. Knowledge gained from these studies will inform future studies aimed at repairing and restoring damaged connective tissues in temporomandibular joint disease.

PI_NAMEs: CRUMP, GAGE D (contact);MERRILL, AMY E

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Ablation;Address;Affect;Agonist;Alleles;arthropathies;beta catenin;Breeding;cell type;Cells;Cephalic;Child;chronic pain;chronic painful condition;Clustered Regularly Interspaced Short Palindromic Repeats;Connective and Soft Tissue;Connective Tissue;Connective Tissue Cells;connective tissue development;Data;Data Set;debilitating pain;Defect;Development;Embryo;epithelial stem cell;Equilibrium;experimental study;Failure;Family;Family member;Fishes;Funding;Future;G-Protein-Coupled Receptors;Generations;Genetic;genetic manipulation;Growth;Hair follicle structure;Histology;Homeostasis;Image;Impairment;In Situ;in vivo imaging;Incidence;insight;Internal Ribosome Entry Site;Intestines;Jaw;joint function;joint injury;Joints;Knock-out;Knowledge;Leucine-Rich Repeat;LGR5 gene;Ligaments;LoxP-flanked allele;Lung;Maintenance;Mandible;member;Mesenchymal;Mesenchymal Stem Cells;Mesenchyme;Modeling;mouse genetics;mouse model;Mus;Muscle;mutant;National Institute of Dental and Craniofacial Research;Neural Crest Cell;NR5A2 gene;Nuclear;Nuclear Receptors;Organ;Pattern;pharmacologic;pluripotency factor;Population;postnatal;prevent;Process;progenitor;Proteins;receptor;Regulation;repaired;Reporter;Research;Resolution;RNA;Role;Signal Transduction;single-cell RNA sequencing;Site;skeletal;skeletal stem cell;skeletal tissue;Skeleton;Source;stem;stem cell biology;stem cell differentiation;stem cell exhaustion;stem cell function;stem cell population;stem cells;Structure;Structure of articular disc of temporomandibular joint;System;Target Populations;Temporomandibular Joint;Temporomandibular Joint Disorders;tendon development;Tendon structure;Testing;Time;Tissue Differentiation;tissue stem cells;Tissues;tool;Validation;Visualization;WNT Signaling Pathway;Work;Zebrafish

PROJECT_TITLE: Role of LGR+ connective tissue progenitors in TMJ development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-L (03)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lung;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: PROJECT NARRATIVE Metastasis of cancer cells from the bone to the lung is responsible for the majority of osteosarcoma patient deaths, but how this process happens is not completely understood. Platelets are known to facilitate metastasis of other cancers, and studies have shown that cancer progression can affect megakaryocytes (platelet producing cells) but specific interactions between osteosarcoma cells, megakaryocytes, and platelets have not been established. This proposal focuses on examining how interactions between osteosarcoma cells and megakaryocytes in the bone marrow influence how megakaryocytes make platelets, alter the function of those platelets, and promote osteosarcoma metastasis to the lungs.

PI_NAMEs: TRAVIS, OLIVIA KRISTELL (contact)

PROJECT_TERMS: Adolescent;Affect;Agonist;Apoptosis;Automobile Driving;Biological Assay;Blood Platelets;bone;bone cell;Bone Marrow;cancer cell;cancer type;candidate identification;career;Cell Communication;cell motility;Cell Proliferation;Cells;Cessation of life;Coculture Techniques;Data;Data Analyses;Development;Disease;Distant Metastasis;effective therapy;Experimental Designs;experimental study;Flow Cytometry;Funding Opportunities;Future;Gene Expression;Goals;Immature Bone;Immunohistochemistry;Implant;implantation;Implantation procedure;improved;In Vitro;in vivo;in vivo imaging system;Injections;innovation;interdisciplinary approach;Invaded;Knowledge;Lead;limb amputation;Localized Disease;Lung;Lung Neoplasms;Malignant Breast Neoplasm;Malignant Neoplasms;Mature Bone;Measurement;Measures;Mediating;Mediator;Megakaryocytes;Metastatic Neoplasm to the Lung;Metastatic Osteosarcoma;migration;Modeling;Morphology;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;novel;Operative Surgical Procedures;Osteoblasts;Osteosarcoma;Pathway Analysis;Pathway interactions;Patient-Focused Outcomes;Patients;Platelet Activation;Platelet aggregation;platelet function;Play;Ploidies;Polyploidy;Primary Neoplasm;Procedures;Process;Production;Proliferating;protein expression;Proteins;Proteome;Proteomics;Research;Research Personnel;Resected;RNA;Role;Signal Pathway;Signal Transduction;skills;Survival Rate;Tail;Techniques;Testing;Therapeutic;therapeutic target;tibia;Time;Toxin;Training;transcriptome;transcriptome sequencing;transcriptomics;tumor;Tumor Cell Invasion;tumor growth;tumor progression;Tumor Promotion;Veins;Wild Type Mouse

PROJECT_TITLE: Impact of bidirectional signaling between megakaryocytes and osteosarcoma cells on metastasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-Z (20)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Neurosciences;Pediatric;Substance Misuse

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: PROJECT NARRATIVE Cannabis is the most used illicit drug among adolescents, which is concerning given that adolescents undergo considerable brain and behavioral development—processes that may be disrupted by cannabis leading to long- lasting consequences. This proposal will investigate microglia as a mechanism underlying cannabis-induced cognitive dysfunction in adulthood that we have previously reported following adolescent vaporized cannabis use. These findings will provide important insight into the biological targets of vaporized cannabis during adolescence, and the mechanisms through which they mediate long-term neurocognitive dysfunction.

PI_NAMEs: WESTBROOK, SARA RUTH (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Adolescence;Adolescent;Adolescent Development;Adult;Age;Agonist;Behavioral;Biological;Brain;Brain region;cannabinoid receptor;cannabinoid treatment;Cannabinoids;Cannabis;Cognition;Cognitive;cognitive function;Complex;Data;density;Development;Drug Exposure;early onset;Electrophysiology (science);Environment;Extracellular Matrix;flexibility;Functional disorder;Genetic;glial activation;hippocampal pyramidal neuron;Human;illicit drug use;Immunohistochemistry;Impaired cognition;Impairment;Inhibitory Synapse;Injections;insight;Interneuron function;Interneurons;marijuana use;marijuana user;marijuana vaping;Medial;Mediating;Microglia;Modeling;Mus;neural;Neurocognitive;Neuroglia;Neurons;Neurophysiology - biologic function;neurotransmitter release;Output;Parvalbumins;Play;Positioning Attribute;preclinical study;Predisposition;Prefrontal Cortex;preservation;prevent;Process;Psychopathology;Rattus;Reporting;Role;Slice;Structure;Testing;Time;transmission process;United States;vapor

PROJECT_TITLE: Investigating microglia as a mechanism of adolescent cannabis-induced medial prefrontal cortex dysfunction


NIH_SPENDING_CATS: Genetics;Regenerative Medicine

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

PHR: PROJECT NARRATIVE Zebrafish regenerate amputated fins to their original size and shape, as controlled by fibroblast-lineage cells. The applicant’s proposed fellowship research would investigate how these cells transition between previously undescribed cell states to slow down and stop regeneration as the original organ size is reached. Understanding such mechanisms that trigger and sustain pro-growth cell states could enhance wound healing and tissue regenerative medicine in humans.

PI_NAMEs: MARKOVIC, HANNAH  (contact)

PROJECT_TERMS: Adult;Affect;Amputation;Apoptosis;Apoptotic;Back;Behavior;bioelectricity;blastema;career;Cell Communication;Cell Count;cell growth;Cell Lineage;Cell membrane;Cell Proliferation;Cells;Cellular Assay;Complement;Connexin 43;Connexins;Coupled;Data;data quality;Data Set;Developmental Biology;Differential Equation;differential expression;Disabled Persons;Distal;Doctor of Philosophy;Ectopic Expression;Epithelium;Equation;Fellowship;Fibroblasts;Fishes;Gap Junctions;Genes;Genetic Transcription;Geometry;Goals;Human;imaging approach;improved;Individual;Injury;Label;Laboratories;Learning;Length;Link;Literature;Maps;mathematical model;Mathematics;member;Membrane;Membrane Potentials;Mesenchymal;Mesenchyme;Methods;migration;Modeling;mutant;Mutation;Natural regeneration;Oregon;Organ;Organ Size;Persons;Phenotype;Population;Positioning Attribute;Postdoctoral Fellow;Potassium Channel;prevent;Production;Proliferating;quantitative imaging;regenerative;Regenerative Medicine;regenerative tissue;Regulation;Research;Research Personnel;restoration;self-renewal;Shapes;Signal Transduction;single-cell RNA sequencing;skeletal disorder;skeletal injury;Skeleton;Snails;solute;stem cells;symposium;System;Testing;Tissues;Training;Training Programs;transcription factor;transcriptome;transcriptomics;Universities;voltage;voltage gated channel;wound healing;Zebrafish

PROJECT_TITLE: Fibroblast-lineage cell state transitions during zebrafish fin regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


NIH_SPENDING_CATS: Aging;Contraception/Reproduction;Genetics;Infertility;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SALT LAKE CITY

PHR: PROJECT NARRATIVE Mean paternal age in the United States has been increasing for the past 40 years. At the same time, there is increasing evidence that advanced paternal age correlates with negative effects for offspring. The goal of this project is to use clonal analysis in the zebrafish testis to expand our understanding of the biological mechanisms of male fertility across the lifespan, with particular attention paid to the Paternal Age Effect (PAE) disorders that cause severe developmental abnormalities in children.

PI_NAMEs: WEBER, JENNA MICOLE (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Adult;Age;age effect;age related;Aging;Animals;Attention;autosome;Back;Bar Codes;Basic Science;Biological;Birth;Child;Clinical;Clinical Skills;Clonality;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Collection;Communication;Congenital Disorders;cost;CRISPR/Cas technology;Data;design;Development;Disease;Educational process of instructing;Elderly;Embryo;Embryo Deaths;Epidemiologic Methods;Equilibrium;experimental study;Fathers;Female;Fertility;FGFR2 gene;FGFR3 gene;Future;gain of function mutation;Gene Transfer Techniques;Genes;Genetic;Genetic Engineering;Germ-Line Mutation;germline stem cells;Goals;Grant;Health;human disease;human model;improved;in vivo;Individual;Inheritance Patterns;Inherited;Intervention;Intrinsic factor;Knowledge;Label;Learning;life span;Link;Literature;male;male fertility;Male Genital Organs;Manuals;MAP Kinase Gene;mathematical model;Measures;medical schools;Mentors;Mentorship;model organism;Molecular;Molecular Abnormality;Monitor;Morbidity - disease rate;mosaic;mutant;Mutate;Mutation;Mutation Detection;Neoplasms;next generation;novel strategies;offspring;Outcome;overexpression;Paternal Age;Pathway interactions;Patient Care;Pediatrics;Physicians;Point Mutation;Population;Population Analysis;Population Dynamics;Preparation;Production;PTPN11 gene;RAS genes;reproductive;Reproductive Endocrinology;Reproductive Health;reproductive senescence;Research;Risk;Sampling;Scientist;self-renewal;skills;sperm cell;Spermatogenesis;stem cell niche;stem cell population;stem cells;Structure of primordial sex cell;supportive environment;System;Testing;Testis;theories;Time;tool;Training;transmission process;United States;Writing;Zebrafish

PROJECT_TITLE: Paternal age effect mutations as selfish drivers of germline stem cell clonality

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F06-L (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Cerebrovascular;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Vector-Borne Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Alphaviruses like Sindbis (SINV) and chikungunya (CHIKV) virus, can cause encephalitis by crossing the blood- brain barrier, likely via infection of the brain microvascular endothelial cells that make up the barrier. Seminal work in the field has identified residues in the SINV and CHIKV E2 glycoproteins that are critical for neuroinvasion in vivo, while additional work has separately identified host receptors that interact with SINV and CHIKV E2. We expand upon these findings by characterizing the relationship between these E2 residues and known E2 interactors at the blood-brain barrier, thus laying the groundwork for novel treatments against the increasing threat of a large scale CHIKV outbreak.

PI_NAMEs: ALVAREZ, PABLO  (contact)

PROJECT_TERMS: Affinity;Alpha Virus;Arthritis;Astrocytes;Attenuated;Binding;Biological Assay;Blood - brain barrier anatomy;blood-brain barrier crossing;brain endothelial cell;California;cell type;Cell-Matrix Junction;Cells;Central Nervous System;chikungunya;chikungunya infection;Chikungunya virus;Chimera organism;Communication;Disease Outbreaks;Educational process of instructing;Encephalitis;Endothelial Cells;Environment;Experimental Designs;Fellowship;Flavivirus;Foundations;Genetic Determinism;Glycoproteins;Heparitin Sulfate;Human;Immune;in vivo;Infection;Inflammation;inhibitor;insight;Integration Host Factors;Intervention;Los Angeles;Macaca fascicularis;Maps;Mediating;Medical;Modeling;Molecular;molecular targeted therapies;mosquito-borne;multidisciplinary;Mus;Neurologic;Neuropathogenesis;neuropathology;novel;Pericytes;pharmacologic;Phenotype;Pluripotent Stem Cells;programs;Proteins;Publishing;receptor;Research Training;Role;Science;Seminal;Sindbis Virus;stem cell model;stem cells;Testing;Therapeutic;Therapeutic Research;tool;Training;Umbilical vein;Universities;Virus;virus genetics;Work

PROJECT_TITLE: Unraveling alphavirus neuroinvasion: Molecular insights from a stem cell based blood-brain barrier model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Cancer;Liver Disease;Nutrition;Obesity;Orphan Drug;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative Obesity-associated hepatocellular carcinoma (HCC) is a highly lethal cancer that is a rising and challenging problem and in dire need of safer and more effective treatments. I hypothesize that the inhibition of cytochrome P450 family 8 subfamily B member 1 (CYP8B1), an enzyme expressed only in the liver, will significantly reduce formation of cholic acid (CA), the 12α-hydroxylated (12α-OH) primary bile (BA), and consequently, drastically decrease the ratio of 12α-OH to non-12α-OH BAs and the levels of deoxycholic acid, a secondary BA derived from CA by gut microbiota, thereby suppressing obesity-associated HCC development. I will determine the role of CYP8B1 in an obesity-associated HCC mouse model and develop novel CYP8B1 inhibitors as potential drug candidates for the treatment of obesity-associated HCC.

PI_NAMEs: AGUA, ALON ROY LLAGAS (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Adult;Affinity;Animals;Bile Acids;Bile fluid;Binding;Biochemical;Biological Assay;Cancer Etiology;Carcinogens;Cells;Cessation of life;Chemicals;Cholic Acids;Classification;Complex;CYP8B1 gene;Cytochrome P450;Data;Deoxycholic Acid;design;Development;Diabetes Mellitus;Diet;diet-induced obesity;Diethylnitrosamine;Docking;drug candidate;effective therapy;Enzymes;Evaluation;Family;Future;Gene Deletion;Gene Mutation;Genes;Growth;gut microbiota;Hepatocyte;High Fat Diet;high throughput screening;Human;Hydroxylation;Immunohistochemistry;improved;in vivo;inhibitor;Knockout Mice;Lead;lead candidate;Libraries;Link;Liver;loss of function mutation;Malignant Neoplasms;member;Metabolic Diseases;Metabolism;microbiota composition;Modification;Molecular;mouse model;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutic intervention;Obesity;obesity development;obesity treatment;Oncogenes;Patients;Pharmaceutical Preparations;Play;polypeptide;Prevalence;Primary carcinoma of the liver cells;Proteins;Reporting;Risk;Rodent;Role;Structure;Structure-Activity Relationship;Survival Rate;Testing;Therapeutic;treatment strategy;tumor growth;Wild Type Mouse;X ray diffraction analysis

PROJECT_TITLE: Development of novel CYP8B1 inhibitors


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Sleep Research

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative Sleep problems are prevalent in individuals with neurodevelopmental conditions, such as autism spectrum disorder (ASD), which can have deleterious effects on brain development and behavioral outcomes. The proposed studies will longitudinally examine the impacts of infant sleep disturbances on brain connectivity and developmental trajectories in both typical and atypical development. These findings will inform the utility of distinct sleep metrics as an early biomarker for altered neurodevelopment, leading to earlier detection and interventions for neurodevelopmental conditions.

PI_NAMEs: CHIEM, EMILY  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: 2 year old;actigraphy;Adaptive Behaviors;Affect;autism biomarker;autism spectrum disorder;autism symptoms;autistic children;Behavior;Behavior assessment;Behavioral;behavioral outcome;Brain;Brain imaging;career;Child Development;Childhood;Clinical assessments;clinical diagnosis;Cognition;Cognitive;cognitive development;cognitive function;cohort;Collection;Communities;Data;Data Analytics;Development;Diagnosis;Diagnostic;early detection biomarkers;Early Diagnosis;Early identification;Early Intervention;Environment;Etiology;Family history of;Fellowship;Functional Magnetic Resonance Imaging;Funding;graduate student;Image;imaging study;improved;Individual;individuals with autism spectrum disorder;infancy;Infant;insight;Intervention;Knowledge;Language;language impairment;Learning;Life;Link;Longitudinal Studies;longitudinal, prospective study;Machine Learning;Magnetic Resonance Imaging;Measures;Mediating;Mediation;Mentors;Mentorship;Methods;Modeling;Molecular;multimodality;neural;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;novel;Older Population;Outcome;Parents;Pattern;Physiology;Population;Process;programs;Reporting;Research;Resources;Rest;Risk;Role;Sampling;Sensory;sensory cortex;Siblings;skills;Sleep;Sleep Disorders;Sleep disturbances;sleep onset;sleep pattern;Symptoms;Thalamic structure;Time;Training;training opportunity;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Early Sleep Disruption and Neurodevelopmental Trajectories in Infancy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


NIH_SPENDING_CATS: Aging;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE Hematopoietic stem cells (HSCs) regenerate all blood cells throughout life, but their function declines with age. This proposed research will investigate the role of translation fidelity in promoting protein homeostasis, HSC fitness, and longevity during aging. Investigating the role of translation fidelity in HSC function and longevity is critical for developing new therapeutic targets that mitigate age-associated functional declines of HSCs and to enhance the regenerative capacity of stem cells in older adults.

PI_NAMEs: DANIELS, AMANDA J (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Adult;Age;age related;age related changes;age related decline;Aging;aging population;Anemia;Biological Assay;Blood;Blood Cells;Bone marrow failure;cell type;Cells;Cellular Assay;Data;exhaust;exhaustion;Exhibits;experimental study;fitness;Fluorescence;functional decline;Functional disorder;Gene Expression;hallmarks of aging;Health;healthspan;Hematologic Neoplasms;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic;hematopoietic stem cell aging;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Human;Immune;Immune System Diseases;Immunity;Impairment;improved;In Vitro;in vivo;in vivo Model;Incidence;Intervention;Life;life span;Longevity;Maintenance;misfolded protein;Modeling;mouse model;Mus;Mutation;Myelogenous;new therapeutic target;older adult;Older Population;Outcomes Research;Pathogenicity;preservation;prevent;Process;progenitor;protein aggregation;Protein Biosynthesis;protein purification;Proteins;Proteome;Proteomics;proteostasis;proteostasis loss;regeneration function;Regenerative capacity;Regulation;Reporter;Research;Resolution;Ribosomes;Role;self-renewal;Source;stem cell function;stem cells;Testing;Therapeutic;transcriptome sequencing;translational impact;Translations;Transplantation;Work;young adult

PROJECT_TITLE: Translation fidelity as a modulator of hematopoietic stem cell fitness and longevity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-D (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Infants and young children amass a vocabulary at a remarkable pace and rates of growth between 2 and 3 years of age predict important future outcomes. Research on vocabulary development has largely focused on the cognitive processes underlying how young children learn new words, but we know little about how young children retain newly learned words and integrate them into their lexicon. We propose two experiments using functional magnetic neuroimaging analysis to examine the contribution of the hippocampus, anterior medial temporal lobe and medial prefrontal cortex to the retention and generalization of newly learned words, and general vocabulary extension in toddlers ages 25 to 35 months of age, thereby building a more comprehensive theory of vocabulary development.

PI_NAMEs: GHETTI, SIMONA  (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: 2 year old;3 year old;Academic achievement;Affect;Age;Age Months;Anterior;auditory stimulus;autism spectrum disorder;Behavioral;Child;cognitive process;Communication;comparison control;Development;Down's Syndrome;Environment;Exhibits;experimental study;Exposure to;Familiarity;Foundations;Functional Magnetic Resonance Imaging;Future;Growth;Hippocampus;Home;imaging study;Impairment;Individual Differences;Infant;insight;Label;Language Development;Learning;Left;lexical;Magnetism;Medial;medial temporal lobe;Memory;memory retention;Methodology;Modeling;neural;neural correlate;Neurodevelopmental Disorder;neuroimaging;neuromechanism;novel;Outcome;Population;Prefrontal Cortex;Process;public health relevance;reading ability;Research;Role;Semantics;Sleep;Structure;Testing;theories;Time;Toddler;Vocabulary;word learning

PROJECT_TITLE: Neural Substrates of Word Retention and Generalization in Toddlers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-H (02)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Infertility;Prevention

ORG_DEPT: GENETICS

PHR: Project Narrative Male infertility is a highly prevalent yet poorly understood condition that clinically manifests in combination with poor somatic health, especially in terms of elevated cancer risks for affected males and their families. This proposal will use high-depth DNA sequencing to explore novel relationships between germline and somatic mutagenesis, reduced fertility, and poor somatic health. The results obtained from this proposal will guide future research efforts to elucidate the biological, genetic, and cellular mechanisms underlying the etiology of male infertility and its associations with reduced health.

PI_NAMEs: KUNISAKI, JASON  (contact)

PROJECT_TERMS: Acute Lymphocytic Leukemia;Affect;Age;Aneuploidy;Automobile Driving;base;Biological;Biological Process;cancer risk;Cardiovascular Diseases;Cell Lineage;Cell Physiology;Child;Chromosome abnormality;Clinical;Clinical Management;comorbidity;Complementary DNA;Complex;Conceptions;Congenital Abnormality;Couples;de novo mutation;Development;Diagnosis;DNA Fragmentation;DNA Repair Gene;DNA sequencing;Environment;epidemiologic discoveries;epidemiology study;Etiology;Exhibits;Family;Fertility;Functional disorder;Future;Genes;Genetic;genetic pedigree;Genetic Processes;Genome;Germ Lines;Germ-Line Mutation;Health;Hereditary Malignant Neoplasm;High-Risk Cancer;Human;Immunoglobulin Somatic Hypermutation;Impairment;Individual;Infertility;insight;Investigation;Knowledge;Laboratory Finding;life span;Link;male;Male Infertility;Malignant neoplasm of prostate;Malignant neoplasm of testis;Malignant Neoplasms;men;Mutagenesis;Mutation;novel;Nucleotides;Pathologic Mutagenesis;Pathway interactions;Pattern;Prevalence;Production;Prostate;reproductive;Reproductive Health;Research Proposals;Risk;Role;Sampling;Seminal fluid;Somatic Mutation;Source;sperm cell;Spermatogenesis;stem cells;Testing;Translating;Tumor Biology;Utah;Work

PROJECT_TITLE: Investigating the relationship between genome mutagenesis, fertility, and health in fertile and infertile men