ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Infectious Diseases;Natural Products

ORG_CITY: ANN ARBOR

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed research will impact human health by developing high throughput synthetic approaches to azaphilone compounds, a class of fungal natural products. Specifically, sustainable biocatalytic strategy will be developed for the facile synthesize of complex azaphilone natural products which will then be assayed for biological properties. This work will further the understanding of azaphilone natural products and their potential as therapeutics for human diseases.

PI_NAMEs: TORMA, KATHERINE JANE (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Alternative Medicine;analog;Anti-Bacterial Agents;anti-cancer;anti-fungal agents;Anti-Inflammatory Agents;anticancer activity;antimicrobial;Bacterial Infections;Biological;Biological Assay;Breathing;carbonyl group;catalyst;China;Cholesterol;Cholesterol Synthesis Inhibition;Complex;Complex Mixtures;Coumarins;Coupling;Cytochrome P450;cytotoxic;Development;Dimerization;Disease;drug development;drug structure;Enzymes;Family;Family member;Fermentation;Fluorescence Polarization;Fungal natural products;fungus;Health;Health Food;Human;human disease;Investigation;Lead;Libraries;Life;Malignant Neoplasms;Medicine;method development;Methods;Molds;Monascus;Mycoses;Natural Products;Natural Source;novel;novel strategies;Organism;Oxidoreductase;Pathway interactions;Periodicity;Plants;Process;Property;protein protein interaction;Reaction;Reagent;Reporting;Research;Rice;Route;scaffold;secondary metabolite;Series;Site;small molecule;small molecule therapeutics;Source;Structure;System;Testing;Therapeutic;Time;tool;Traditional Medicine;Viral;Viral Physiology;Virus Diseases;Work

PROJECT_TITLE: Late-stage functionalization and bioactivity investigation of azaphilone compounds

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (05)]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE White matter hyperintensities are radiologically defined regions of myelin loss that increase the incidence of Alzheimer’s Disease two-fold and stroke three-fold. The goal of this study is to connect what is known about WMH from the imaging literature to histopathologic studies to enhance future mechanistic studies in WMH pathogenesis and provide insight towards pathologic heterogeneity of these prevailing pathologies. This project will use novel machine learning approaches to (1) comprehensively characterize relationships between cell, myelin, axon, and vascular pathology in WMH lesions, (2) discover WMH histopathologic subtypes, (3) connect regionally informed histopathologic signatures in WMH with clinical outcomes.

PI_NAMEs: JULIAN, DANA  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: adverse outcome;Affect;Algorithms;Alzheimer's Disease;Alzheimer's disease patient;Animal Model;Antioxidants;Architecture;Arterioloscleroses;Astrocytes;Attention;Autopsy;Axon;Basement membrane;Behavior;Biochemical;Blood - brain barrier anatomy;Blood Vessels;Brain;brain tissue;Cell hybridization;Cells;cerebrovascular;Cerebrovascular Disorders;cerebrovascular pathology;cerebrovascular reactivity;Characteristics;Chronic;Clinical;Clinical Data;clinical predictors;clinically relevant;Cognition;comorbidity;deep learning;deep learning model;Dementia;digital;digital pathology;dimension reduction;Disease;Endothelial Cells;Etiology;Event;Experimental Designs;Extravasation;Functional disorder;Future;geriatric depression;Goals;Hematoxylin and Eosin Staining Method;Heterogeneity;Histologic;Histology;Histopathology;Human;human old age (65+);Hypertension;hypoperfusion;Image;Immune;Immunohistochemistry;Impaired cognition;improved;improved outcome;In Situ Hybridization;Incidence;Individual;Inflammatory;insight;interest;Intervention;ischemic injury;Lead;Lesion;Literature;Machine Learning;Macrophage;Magnetic Resonance Imaging;Memory impairment;mental state;Metabolic;Methods;Microglia;Modeling;Motor;Myelin;Neighborhoods;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimaging;neuron loss;Neurons;novel;Oligodendroglia;Onset of illness;Outcome;Pathogenesis;Pathologic;Pathology;Patient-Focused Outcomes;Patients;Pericytes;personalized medicine;Persons;Play;Positioning Attribute;Predictive Value;Predisposition;Prevalence;Radiology Specialty;random forest;regression algorithm;remyelination;Resolution;Risk;Role;Sampling;Scientist;Senile Plaques;Severities;Shapes;skills;Slide;spatial relationship;Speech;Stains;Stroke;Symptoms;System;tau Proteins;Techniques;Testing;theories;therapeutic target;Tissues;tool;Translational Research;unsupervised clustering;Visuospatial;white matter;White Matter Hyperintensity

PROJECT_TITLE: Investigating Cellular Neighborhoods and Tissue Architecture in White Matter Hyperintensities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Human Genome;Maternal Health;Maternal Morbidity and Mortality;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Narrative Spontaneous preterm birth (sPTB) poses an urgent, global threat to both maternal and neonatal health. Though the vaginal microbiome and human genetics have each been independently associated with prematurity, research has yet to disentangle the tripartite relationship between all three entities. I will analyze paired human genotype-microbiome data to infer causality of microbes on sPTB and to predict sPTB risk from both microbes and genetic variants.

PI_NAMEs: URBAN, JULIA ANH (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: 16S ribosomal RNA sequencing;adverse pregnancy outcome;Affect;Benchmarking;Blood Tests;career;Cesarean section;Characteristics;Classification;Clinical;Clinical Data;cohort;Collaborations;computerized tools;Data;Data Set;Data Sources;Development;Diagnostic;diagnostic tool;Equipment;Etiology;Excision;Genes;Genetic;genetic variant;genome sequencing;genome wide association study;genomic locus;genomic profiles;Genotype;Geography;Goals;host-microbe interactions;Human;Human Genetics;Intervention;Investigation;Knowledge;Laboratories;Link;machine learning model;Maternal Health;Mediating;Mendelian randomization;Mentorship;metagenomic sequencing;Metagenomics;Methodology;Methods;Microbe;microbial;microbiome;microbiome composition;Modality;Modeling;Mothers;National Research Service Awards;neonatal health;neonatal morbidity;Neonatal Mortality;novel;Participant;Patients;Physiological;Population;Pre-Eclampsia;predictive modeling;predictive tools;Pregnancy;Pregnancy Trimesters;premature;Premature Birth;prevent;Process;Prospective Studies;Proxy;Quality Control;Race;Reproductive Biology;Research;Research Personnel;Resolution;Risk;Risk Factors;Role;Sample Size;Sampling;Site;social;Swab;Techniques;Therapeutic;Time;tool;Training;Vagina;vaginal microbiome;vaginal microbiota;Validation;Variant;whole genome;Woman;women's reproductive health;Work

PROJECT_TITLE: Deciphering the role of the vaginal microbiome in spontaneous preterm birth via consideration of host genetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cystic Fibrosis;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE Neutrophil extracellular traps (NETs) are being increasingly recognized as important contributors to the pathogenesis of muco-obstructive airway diseases including asthma, chronic obstructive pulmonary disease (COPD), and most prominently in cystic fibrosis (CF). This project will 1) evaluate new potential mechanisms of NETs in altering the biophysical properties of mucus and 2) assess how airway mucus composition modulates the formation of NETs. Successful completion of this study will identify novel mucosal drug targets to catalyze the design of new therapeutics that reduce the impacts of NETs in CF and other chronic pulmonary diseases.

PI_NAMEs: BOBOLTZ, ALLISON MARGARET (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;Affect;airway epithelium;airway obstruction;Apoptosis;Asthma;Bacteria;Bacterial Infections;Biocompatible Materials;biophysical properties;Biophysics;cervicovaginal;Chromatin;Chromatin Modeling;Chromatin Structure;Chronic;chronic infection;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Complex;crosslink;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis infection;cystic fibrosis mucus;cystic fibrosis patients;Defect;Deoxyribonucleases;design;differential expression;Disease;Disease Progression;DNA;Drug Targeting;Electrostatics;Engineering;Epithelial Cells;Epithelium;extracellular;Formulation;Functional disorder;Gel;Glycoproteins;glycosylation;Growth;Histones;Human;human tissue;Hyperviscosity;immunoregulation;Impairment;improved;In Vitro;Incubated;Infection;Inhalation;Internet;Lactoferrin;Leukocyte Elastase;Life;Link;Lung;Mediating;middle ear;Modeling;MUC5AC gene;MUC5B gene;Mucins;muco-obstructive airway diseases;Mucociliary Clearance;Mucous body substance;Mucous Membrane;mucus-associated lung diseases;neutrophil;Neutrophil Activation;new therapeutic target;novel;novel therapeutics;particle;Pathogenesis;Patients;Pattern;Peroxidases;Polysaccharides;prevent;Process;Production;Property;protein complex;Protein Secretion;Proteins;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pulmonary Cystic Fibrosis;pulmonary function;pulmonary function decline;Pyocyanine;Reactive Oxygen Species;Research;response;scaffold;Secretory Cell;Sialic Acids;sialyl Lewis x;Therapeutic;Thick;tissue culture;Tissues;Up-Regulation;viscoelasticity;Viscosity;Work

PROJECT_TITLE: New biophysical and immunoregulatory mechanisms in neutrophil extracellular trap mediated lung dysfunction in cystic fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Kidney Disease

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative Nephrotic syndrome (NS), a rare kidney disease that nevertheless is the second leading cause of end stage renal disease in patients under 25. Rare loss of function variants within NPHS1, which encodes the protein nephrin, critical to maintenance of the slit diaphragm of the glomerulus, are known to cause severe forms of NS with recessive inheritance. This study will discover the clinical consequences of NPHS1 variants across the allele frequency spectrum by studying the association of heterozygous rare pathogenic coding variants and common non-coding variants with kidney disease states and quantitative phenotypes of kidney dysfunction.

PI_NAMEs: BANERJI, ADRIAN OLAF (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Age;Age of Onset;Alleles;biobank;Carrier State;Chronic Kidney Failure;Clinical;Clinical Management;Code;cohort;Disease;End stage renal failure;Enrollment;founder mutation;Functional disorder;gene discovery;Gene Frequency;General Population;Genetic;genetic architecture;Genetic Variation;genome wide association study;Genotype;Glomerular Filtration Rate;Goals;Health system;Heterozygote;Hospitals;Immunosuppression;improved;Individual;Kidney;Kidney Diseases;kidney dysfunction;loss of function;Maintenance;Measures;Meta-Analysis;Modeling;Morbidity - disease rate;nephrin;Nephrotic Syndrome;Pathogenicity;Patients;Persons;Phenotype;Population;Prevalence;primary nephrotic syndrome;primary outcome;protective allele;Proteins;Proteinuria;Publishing;Qualifying;response;Risk;risk variant;secondary outcome;Serum Albumin;Severity of illness;slit diaphragm;Steroid-resistant idiopathic nephrotic syndrome;Steroids;System;targeted treatment;Testing;Therapeutic;trait;treatment response;Untranslated RNA;Urine;Variant

PROJECT_TITLE: Discovering the Consequences of Genetic Variation in Nephrin on Kidney Diseases and Traits in Biobank Populations

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Kidney, Urology, and Hematology[DDK-G]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Genetics;Mental Health;Mental Illness;Nutrition;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: EAST LANSING

ORG_DEPT: PSYCHOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE Binge eating is a significant mental health problem that affects a substantial proportion of males, and results in several negative psychiatric and medical consequences. Nonetheless, there is a paucity of research examining risk for binge eating in boys and men, and biological risk factors are extremely understudied. Identifying pubertal activation of phenotypic and genetic effects of androgens on binge eating could reveal a critical set of male-specific biological processes important for disease susceptiblity and novel targets for more personalized prevention and intervention efforts.

PI_NAMEs: CULBERT, KRISTEN ;KLUMP, KELLY L (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Acute;Address;Administrative Supplement;Adolescent;adolescent mental health;Adrenal Glands;Affect;Age;Androgens;Animals;Anxiety;Area;Authorization documentation;Awareness;Back;Behavioral Symptoms;Binge Eating;Biological;Biological Assay;Biological Factors;Biological Process;Biometry;boys;Budgets;Caregivers;Child;Chronic;Communities;cost;COVID-19;COVID-19 impact;COVID-19 pandemic;Data;Data Collection;Development;Disease;Eating;Eating Disorders;Ensure;Equation;ethnic minority;Etiology;experience;Family;Financial Support;Funding;Genes;Genetic;Genetic Risk;Genetic Transcription;Goals;Hormones;human data;improved;individualized prevention;innovation;insight;Interview;Libido;male;Medical;men;Mental Depression;Mental Health;Methods;Michigan;Modeling;Moods;Morbidity - disease rate;Neurobiology;novel;Obesity;pandemic disease;parent grant;Parents;Participant;Patient Recruitments;personalized intervention;Persons;Phenotype;post-COVID-19;preference;preservation;Prevention;protocol development;Protocols documentation;Puberty;Public Health;Questionnaires;racial minority;recruit;Registries;Regulator Genes;Reproducibility;Research;Research Assistant;Resources;Risk;Risk Factors;Role;saliva sample;Same-sex;Sample Size;Sampling;Schedule;severe COVID-19;Sex Differentiation;Syndrome;System;Testosterone;Training;Transportation;Twin Multiple Birth;Twin Studies;undergraduate research;Universities;virtual assessment;Work

PROJECT_TITLE: A Twin Study of Androgen Effects on Binge Eating Risk during Puberty in Males

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative This proposal describes the training and mentoring of Ms. Aria Pearlman Morales and her research project which develops a novel bio-orthogonal targeting system capable of delivering novel nucleic acid therapies that traffic directly to the organ via systemic dosing. Using this system, she describes a method for preventing systemic immunosuppression and associated drug toxicity, paving a new way for the induction of organ specific immune tolerance. The capability of this system to allow for donor organ specific drug delivery and minimization of off- target toxicity will be evaluated.

PI_NAMEs: PEARLMAN MORALES, ARIA  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Anatomy;Animal Model;Awareness;Binding;Biocompatible Materials;Blood Vessels;Cause of Death;Cell surface;Cells;Chimerism;Clinical;Clinical Medicine;Clinical Skills;Communicable Diseases;Communication;density;Development;Diabetes Mellitus;Docking;Donor person;Dose;Drug Delivery Systems;Drug Targeting;Drug toxicity;Endocytosis;Endothelial Cells;Endothelium;Evaluation;ex vivo perfusion;experimental study;Formulation;Geography;Glycocalyx;Goals;Health;Heart Diseases;Heart Transplantation;Heterotopic Transplantation;Human;Hyperlipidemia;Hypertension;Image;Immune;Immune Tolerance;Immunosuppression;Immunosuppressive Agents;Implant;implantation;in vivo;Incidence;Inflammation;Interdisciplinary Study;knock-down;Lentivirus;Leucine Zippers;Life;lipid nanoparticle;Living Donors;Location;Malignant Neoplasms;Mentors;Methods;Modeling;Morbidity - disease rate;mouse model;multidisciplinary;Mus;nanoparticle;novel;nucleic acid delivery;nucleic acid-based therapeutics;Nucleic Acids;Organ;Organ Donor;Organ failure;organ transplant recipient;Organ Transplantation;Organ Viability;particle;Pathway interactions;Patients;Peptides;Perfusion;Physicians;Physiological;precision drugs;pressure;prevent;programs;Research;Research Project Grants;restraint;Risk Factors;Scientist;shear stress;side effect;siRNA delivery;skills;Stress;Surface;Survival Rate;System;Technology;Therapeutic;Therapeutic immunosuppression;Thick;Time;Toxic effect;trafficking;Training;Transfection;transplant model;Transplant Recipients;Travel;Treg therapy;Trust;two-dimensional;uptake;Vascular Endothelium;Wait Time;Work

PROJECT_TITLE: A Bio-orthogonal Targeting System for Precision Drug Delivery to Vascular Endothelium in Transplanted Organs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-B (20)]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Congenital Heart Disease (CHD), or developmental malformation of the heart, affects around 1% of all live births and is among the major causes of infant death in the United States. In order to understand the underlying genetic and molecular mechanisms of heart development, we must study the roles genes found in genome wide association studies from these patients, such as TNRC18. This will allow us to better serve the needs of the patients and our unified search for cures and treatments to improve patient outcomes.

PI_NAMEs: RUSHING, AMY  (contact)

PROJECT_TERMS: Affect;Aorta;Biology;Candidate Disease Gene;Cardiac;cardiogenesis;career;Cells;cellular imaging;Childhood;Chromatin;chromatin modification;Chromatin Remodeling Factor;Cilia;ciliopathy;cilium motility;clinically significant;Complex;Computer software;Congenital Abnormality;congenital heart abnormality;CRISPR/Cas technology;Data;Defect;Development;Developmental Cell Biology;Diagnosis;Disease;disease model;disease phenotype;Embryo;Embryonic Development;exome sequencing;experimental study;Fluorescence Microscopy;Future;Gene Silencing;Genes;Genetic;Genetic study;genome wide association study;Genotype;Goals;Heart Abnormalities;Heterozygote;Human;human disease;Image;improved;In Situ;In Situ Hybridization;Infant Mortality;insight;Investigation;knock-down;Large-Scale Sequencing;Left;Life;Live Birth;loss of function;Machine Learning;Mentors;Mentorship;Messenger RNA;model organism;Modeling;Molecular;Molecular Biology Techniques;Morphology;mortality;Mutation;novel;Oligonucleotides;Optics;Oral;Organogenesis;Outcome;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Phenotype;Physicians;Play;protein function;Proteins;Research;Role;Scientist;Siblings;Sister;Site-Directed Mutagenesis;Situs Inversus;skills;spatiotemporal;Speed;Structure;Symptoms;System;Techniques;Testing;therapy development;Training;Transcript;transcriptome sequencing;Trinucleotide Repeats;United States;Variant;Visualization;Work;Writing;XenBase;Xenopus

PROJECT_TITLE: Investigation of TNRC18 in Left-Right Patterning and Congenital Heart Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE The ability of pulsed ultrasound (pUS) to noninvasively modulate the immune system offers an unprecedented opportunity to improve outcomes in chronic inflammatory diseases such as chronic kidney disease (CKD). We have used pUS as a pretreatment to provide protection in preclinical models of acute kidney injury. In this work, we propose to leverage the immunomodulatory effects of pUS to develop a novel therapy for CKD with a goal towards laying the groundwork for future clinical trials.

PI_NAMEs: GOGGINS, EIBHLIN  (contact)

PROJECT_TERMS: Acetylcholine;Acute;Acute Renal Failure with Renal Papillary Necrosis;Adoptive Transfer;Affect;Albuminuria;alpha-bungarotoxin receptor;Anti-Inflammatory Agents;Attenuated;beta-2 Adrenergic Receptors;Binding;Cell Physiology;Cells;Choline O-Acetyltransferase;cholinergic;Chronic;chronic inflammatory disease;Chronic Kidney Failure;Clinical;Clinical Research;clinical training;Clinical Trials;Collaborations;Communication;Communities;cytokine;Data;Denervation;Disease Progression;FDA approved;Fellowship;Fibrosis;Fluorescence-Activated Cell Sorting;Folic Acid;Fostering;Future;Goals;Histologic;Homeostasis;Immune;Immune system;Immune Targeting;Immunologics;Immunology;immunoregulation;improved outcome;in vivo;Inflammation;Inflammatory;Injections;Injury;Injury to Kidney;innovation;Intervention;Ischemia;Kidney;Kidney Diseases;kidney fibrosis;kidney preservation;knowledge base;Learning;Limb structure;Link;Literature;Macrophage;Mediating;Methods;Modality;Modeling;Monitor;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;Nephrology;Nerve;neural circuit;Neuroimmune;Neuroimmunomodulation;Neurosciences;new technology;Norepinephrine;novel;novel therapeutics;Pathway interactions;Patients;Pharmacologic Substance;Pharmacotherapy;Phenotype;Physiologic pulse;Plasma;Population;Pre-Clinical Model;preclinical study;prevent;Prevention strategy;Process;Production;protective effect;Reflex action;Regimen;Renal function;renal ischemia;repaired;Reperfusion Injury;Research;Research Personnel;Risk Factors;Safety;side effect;Signal Transduction;skill acquisition;Spleen;Splenocyte;Stimulus;T-Lymphocyte;Techniques;Technology;Testing;Therapeutic;Toxin;Training;training opportunity;transmission process;Treatment Efficacy;Ultrasonic Therapy;ultrasound;Universities;vagus nerve stimulation;Vagus nerve structure;Virginia;Work

PROJECT_TITLE: Effect of Pulsed Splenic Ultrasound on delaying Chronic Kidney Disease Progression through a Neuroimmune Mechanism.


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative: The post-translational modification (PTM) of histones that package eukaryotic genomes into chromatin are integral to the regulation of gene expression. The SAGA (Spt-ADA-GCN5-acetyltransferase) complex, capable of H3 acetylation and H2B deubiquitination, is a transcriptional co-activator involved in nearly all Pol II mediated transcription and contains two enzymatic complexes: the histone acetyltransferase (HAT) module and deubiquitinating (DUB) module. In my studies, I am to bridge the gap in our mechanistic understanding of SAGA’s regulation of transcription, such as how SAGA exerts its reader, writer, and eraser functions to regulate gene expression on a poly-nucleosome template and how the SAGA HAT module acetylates chromatin to promote active transcription.

PI_NAMEs: FIELDS, JAMES KEMPER (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Acetylation;Acetyltransferase;Address;Alanine;Binding;Biochemical;Biological Assay;Bromodomain;c-myc Genes;Catalytic Domain;Chromatin;Complementary DNA;Complex;crosslink;Cryoelectron Microscopy;Data;density;Deubiquitination;Dinucleosome;DNA Polymerase II;EMSA;Enzymes;Event;Excision;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genome;Goals;Histone Acetylation;histone acetyltransferase;Histone H2B;Histone H3;histone modification;Histones;Human;insight;Knowledge;Libraries;Malignant Neoplasms;Mediating;Methylation;Molecular Conformation;molecular dynamics;mutation screening;new therapeutic target;Nucleosomes;Peptides;Play;Post-Translational Protein Processing;Proteins;Reader;Regulation;Reporting;Research;Role;SAGA;SANT Domain;Scaffolding Protein;screening;Structure;Tail;therapeutic development;therapeutic target;Transcription Coactivator;Transcriptional Regulation;tumorigenesis;Ubiquitin;Ubiquitination;Variant;virtual;Yeasts

PROJECT_TITLE: Mechanisms of SAGA Regulation by Histone Crosstalk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04B-S (20)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: WORCESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative The aim of this proposal is to determine how aberrant activation of nucleic acid-sensing pathways in the central nervous system can hinder remyelination during demyelinating disease. This proposal seeks to identify if this suppression of remyelination is a result of myelin phagocytosis alongside the cell-type and specific receptors responsible. This will further our understanding of inflammation in the brain and could have important therapeutic implications in demyelinating disease.

PI_NAMEs: STILLMAN, JACOB MAXWELL (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Acids;Address;Animal Model;Apoptotic;Autoimmune;Autoimmune Diseases;Automobile Driving;Biology;Brain;career;Carrier Proteins;cell type;Cells;Central Nervous System;central nervous system demyelinating disorder;Chronic;Coupled;Cuprizone;cytokine;Data;Data Analyses;Demyelinating Diseases;Demyelinations;Diet;Electron Microscopy;Endoplasmic Reticulum;Endosomes;experimental study;feeding;Foundations;Future;genetic approach;Genetic Transcription;Gliosis;Goals;Hand;Human;immune cell infiltrate;immune self tolerance;Immune signaling;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Interferon Type I;Interferons;Knock-out;Lesion;light microscopy;Link;LoxP-flanked allele;Lupus;Macrophage;Measures;Mediating;Mentors;Mentorship;Microglia;Microscopy;Modeling;Molecular;Molecular Chaperones;Molecular Genetics;mouse model;Multiple Sclerosis;multiple sclerosis patient;Mus;Myelin;Myelin Sheath;Nerve Degeneration;Neurodegenerative Disorders;neuronal cell body;novel;Nucleic Acids;Oligodendroglia;pathogen;Pathway interactions;Patients;Peripheral;Phagocytes;Phagocytosis;Positioning Attribute;prevent;Process;Progressive Disease;Protein Biosynthesis;Publishing;receptor;receptor function;Receptor Signaling;Regulation;remyelination;response;RNA;Role;Scientist;Self Tolerance;sensor;Signal Transduction;Source;Specificity;Testing;Therapeutic;therapeutic development;Time;TLR2 gene;TLR3 gene;TLR4 gene;TLR7 gene;Toll-like receptors;tool;trafficking;Training;Transcript;transcriptomics;Untranslated RNA;Viral;virtual;Work;Writing

PROJECT_TITLE: Investigating the Role of Endosomal Toll-Like Receptors in Remyelination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative This project aims to revolutionize pancreatic ductal adenocarcinoma (PDAC) treatment by harnessing the unique properties of a specific subtype of cancer-fighting white blood cells, named T cells, that have high levels of a molecule called CD26 on their surface. Most PDAC cells express a molecule called mesothelin, and we propose that the unique T cells expressing CD26 can be genetically modified to recognize mesothelin, kill the cancer cells, and generate an innovative cell therapy. Our proposal will determine mechanisms by which these T cells can limit tumor progression when administered to mice with PDAC and will provide preliminary data for the ultimate application of T cell therapy in PDAC patients.

PI_NAMEs: GEITGEY, DELANEY KATE (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Address;Adopted;Adoptive Cell Transfers;Adoptive Transfer;Antigen Targeting;Antigens;cancer cell;cancer immunotherapy;cancer subtypes;CAR T cell therapy;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Therapy;Cells;cellular engineering;Characteristics;chemokine;chimeric antigen receptor;chimeric antigen receptor T cells;clinically relevant;Complex;congenic;cytokine;Data;Desmoplastic;Development;Dipeptidyl-Peptidase IV;efficacy evaluation;Engineering;Engraftment;enzyme activity;Enzymes;Face;fighting;Fostering;Frequencies;Future;Gene Modified;Genetic;Grant;Hematologic Neoplasms;Human;Immune;immune function;Immune response;Immune system;Immunity;Immunocompetent;immunodeficiency;Immunotherapy;improved;improved outcome;in vivo;Infiltration;inhibitor;innovation;Knock-out;Laboratories;Leukocytes;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediator;Memory;mesothelin;Mesothelioma;Modeling;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Names;neoantigens;neoplasm immunotherapy;novel;novel strategies;overexpression;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Patients;Peptides;Phenotype;Population;pre-clinical;preclinical study;preservation;Property;recruit;Role;Solid Neoplasm;stem;Supporting Cell;Surface;Survival Rate;T cell infiltration;T cell therapy;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;treatment strategy;tumor;tumor microenvironment;tumor progression;Tumor-Derived;tumor-immune system interactions;Work

PROJECT_TITLE: Engineering CD4+ T cells to develop a novel immunotherapy for pancreatic cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (20)]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Hypertension, the leading risk factor for cardiovascular mortality, causes over 10 million avoidable deaths annually. The proposed study aims to characterize responsiveness to mineralocorticoid receptor antagonist in a large clinical trial, and identifying the patient subpopulations who are likely to benefit from a mineralocorticoid receptor antagonist. This research will bridge knowledge gaps in "low-renin" hypertension, enhance understanding of "aldosterone sensitivity," and propose a personalized treatment approach using a mineralocorticoid receptor antagonist for hypertensive patients with low-normal aldosterone.

PI_NAMEs: TAN, JIA WEI  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Adult;Advocate;Age;Aldosterone;Angiotensinogen;Angiotensins;antagonist;Anti-Hypertensive Agents;Benefits and Risks;biomedical data science;Black Populations;Blood;Blood Pressure;blood pressure reduction;blood pressure regulation;blood treatment;cardiovascular risk factor;Cardiovascular system;career;career development;Cessation of life;Characteristics;Chronic Kidney Failure;Clinical;Clinical Research;clinical risk;Clinical Trials;clinically relevant;Collaborations;Data;data management;Dedications;Development Plans;Dose;effective therapy;Elderly;Equation;Event;Exhibits;experience;Female;Frequencies;heart failure with reduced ejection fraction;Hyperaldosteronism;hyperkalemia;Hypertension;hypertension treatment;hypertensive;Incidence;Injury to Kidney;Instruction;interest;Knowledge;low renin hypertension;Master of Science;Mediating;Medical;Mentors;Mentorship;Mineralocorticoid Receptor;mortality;multidisciplinary;obese person;Organ;Outcome;pandemic disease;Participant;Pathway interactions;Patient Agents;patient subsets;Patients;personalized medicine;Pharmaceutical Preparations;Physiology;Plasma;Potassium;Prevalence;Production;Public Health;Regimen;Renin;Research;Research Project Grants;Resistant Hypertension;response;Risk;Safety;Serum;sex;Sodium;Spironolactone;Stroke;Subgroup;Surrogate Markers;symposium;System;Tissues;treatment arm;Treatment Protocols;Water;Woman

PROJECT_TITLE: Mineralocorticoid receptor antagonist use and responsiveness in hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (20)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: PROJECT NARRATIVE Language abilities are heterogeneous in autism spectrum disorder, with widespread impairments; nearly all autistic individuals have pragmatic language deficits, roughly half display structural language impairment, and as many as one-third remain minimally or nonverbal. While the sources of variable language trajectories in autism remain unclear, decreased efficiency in spoken word recognition at the neural level has been implicated as a potential mechanism. The proposed predoctoral training and research project will use electroencephalography (EEG) and machine learning to examine individual differences in the temporal dynamics of spoken word recognition and its relationship to standard clinical measures of language abilities in autistic adults aged 18-35 presenting a wide-range of language abilities and neurotypical language ability-matched peers.

PI_NAMEs: CANALE, REBECCA  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Address;adult with autism spectrum disorder;Age;aged;Auditory;auditory processing;autism spectrum disorder;autistic;Behavior;behavioral study;Brain;Characteristics;Classification;Clinical;cognitive load;cognitive neuroscience;Communication;Communities;Community Outreach;community setting;Computer Models;Connecticut;Dedications;design;Development;Early Intervention;Education;Educational workshop;Electroencephalography;Emotional;Environment;Fellowship;Functional Magnetic Resonance Imaging;functional outcomes;Funding;Grain;Grant;Hearing;Impaired cognition;Impairment;Individual;Individual Differences;individuals with autism spectrum disorder;innovation;Institution;interest;Intervention;Language;Language Disorders;language impairment;language outcome;language processing;lexical;Linguistics;Machine Learning;Manuscripts;Measures;Mentorship;Methodology;Methods;Modeling;multimodality;National Institute on Deafness and Other Communication Disorders;neural;neuroimaging;non-verbal;novel;Outcome;peer;phonology;Population;pre-doctoral;Preparation;Process;programs;Protocols documentation;psychologic;remediation;Reporting;Research;Research Activity;Research Personnel;Research Priority;Research Project Grants;Research Proposals;Resistance;Resolution;Resources;response;responsible research conduct;Role;Science;Signal Transduction;skills;social;Source;Speech;speech processing;standardize measure;support vector machine;symposium;syntax;Testing;Time;Training;training project;United States National Institutes of Health;Update;Work;young adult with autism spectrum disorder

PROJECT_TITLE: Modeling Individual Differences in the Temporal Dynamics of Spoken Word Recognition in Autistic Young Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (35)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

PHR: Narrative This proposal requests support for early career inves4gators and trainees to par4cipate in the Cellular and Molecular Mechanisms of Brain Aging conference to be held in Niagara Falls, NY September 15-19, 2024. The goals of this inter-disciplinary mee4ng are to bring together inves4gators to advance the ﬁeld of neurobiology of aging, to foster career development, and to raise public awareness of this cri4cal area of aging research.

PI_NAMEs: BROWN-BORG, HOLLY M. (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Acceleration;Age;age related neurodegeneration;age-related disease;Aging;aging brain;aging process;aging related;American;Area;Attention;Award;Awareness;Basic Science;biogerontology;Biological Aging;Biological Process;biological research;Biology;Biology of Aging;Biomedical Research;Biotechnology;brain health;career;Career Choice;career development;Career Mobility;clinical practice;Clinical Research;Collaborations;Communication;Communities;design;Developed Countries;Discipline;Educational workshop;Elderly;Eligibility Determination;Ensure;falls;forging;Fostering;Funding;General Population;Geroscience;Goals;Growth;healthy aging;Human;improved;innovation;insight;Joints;K-Series Research Career Programs;Knowledge;Leadership;Life;Medical;meetings;Mentors;Mission;Molecular;Morbidity - disease rate;National Institute on Aging;Neurobiology;New York;next generation;novel;novel strategies;Oral;Outcome;outreach;Policies;Privatization;Process;Program Development;programs;Publishing;recruit;Reporting;Request for Proposals;Research;Research Personnel;Risk Factors;Science;Site;social media;Societies;symposium;Technology;Therapeutic Intervention;therapy development;Translating;United States National Institutes of Health;Update;Work;Writing

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE. The proposed research is relevant to public health because it will elucidate the fundamental biological processes by which the immune system is regulated in response to the microbiome. This essential knowledge is required to understand the role of mucosal immunity in intestinal homeostasis and development of diseases such as inflammatory bowel disease. This work will therefore directly support the overall NIH mission of developing fundamental knowledge that will help reduce the burden of human disease and promote the NIDDK goal of improving digestive health.

PI_NAMEs: EDELBLUM, KAREN LEIGH (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Address;Adenosine;ADORA2A gene;Affect;American;Animal Model;Animals;Anti-Inflammatory Agents;Antibiotic Therapy;Antibiotics;Automobile Driving;Behavior;biobank;Bioenergetics;Biological Assay;Biological Process;Cells;Childhood;Choristoma;Chronic;Coculture Techniques;Coupled;Crohn's disease;cytokine;Data;design;Development;Disease;ecto-nucleotidase;effector T cell;enteric infection;Epithelium;Equilibrium;Exhibits;Exposure to;extracellular;Frequencies;Future;Gene Expression;Goals;gut inflammation;Health;Homeostasis;Human;human disease;Hydrolysis;Ileitis;Immune system;immunoregulation;improved;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;insight;Interleukin-15;intestinal homeostasis;Intestinal Mucosa;Intestines;intraepithelial;Knowledge;Lamina Propria;Link;Lymphocyte;Lymphocyte Count;Lymphocyte Function;Metabolic;metabolic phenotype;Metabolism;metabolomics;microbiome;microbiota;microorganism;Mission;mitochondrial metabolism;Molecular;Motility;mouse model;Mouse Strains;Mucosal Immunity;Mucous Membrane;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;novel;Oxidative Phosphorylation;pathogen;Pathology;Patients;Phenotype;Population;Pouchitis;prevent;Production;Proliferating;prospective;Protein Biosynthesis;Public Health;Receptor Activation;Recurrent disease;Refractory;Regulation;Relapse;relapse prevention;Reporting;Research;Respiration;respiratory;response;Role;Sampling;secondary lymphoid organ;Signal Transduction;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;therapeutic target;TNF gene;transcriptomics;Translating;tripolyphosphate;tumor;United States National Institutes of Health;Up-Regulation;Work

PROJECT_TITLE: CD39 in gamma delta intraepithelial lymphocyte function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-Y (05)]


ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: NARRATIVE The proposed research will use statistical modeling, curated pathway models, and single cell RNA seq atlases to identify within pathways which genes’ expression are informative about regulation of pathway activity and how this is specific to or shared by tissues. Combining our knowledgebases with our vast quantities of publicly available RNA sequencing data will immediately provide a reference for basic, translational, and clinical researchers to which to compare their samples. In the long-term, it will provide a foundation for computational tools employing an interpretable dimensionality reduction of the 20,000 genes in the transcriptome to latent variables describing the transcriptional regulation of each pathway.

PI_NAMEs: MARKARIAN, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: 3-Dimensional;Algorithms;Atlases;Biological;Cell Physiology;cell type;Cells;Clinical;computerized tools;Data;Data Set;Databases;differential expression;dimension reduction;Enzymes;Foundations;Gene Expression;Genes;Genetic Transcription;Glycolysis;Human;improved;Individual;Knowledge;knowledgebase;Label;Left;Logic;Modality;Modeling;Molecular;multimodality;novel;Ontology;Pathway Analysis;Pathway interactions;Pattern;Physiological;Positioning Attribute;Property;receptor;Regulation;Regulatory Pathway;Reporting;Research;Research Personnel;response;Sampling;single-cell RNA sequencing;Specificity;Statistical Models;Stereotyping;Testing;Tissues;tool;Transcription Regulation Pathway;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Coordination of gene expression and molecular function in known pathways


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Photoreceptors are the main sensory neuron in the retina responsible for detecting and transmitting visual information to the brain. Thus, forming the proper synaptic connections between photoreceptors and their respective partners during development is critical for normal visual detection and processing. This proposal elucidates the developmental mechanisms that mediate photoreceptor connectivity, with the long-term goal of elucidating novel approaches to help treat and restore vision loss.

PI_NAMEs: PEREZ, ROSS MICHAEL (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Adult;Affect;Afferent Neurons;Animals;ANK2 gene;ANK3 gene;Ankyrins;Biological Assay;Bipolar Neuron;Blindness;Brain;cell type;Central Nervous System;Color;comparison control;Cone;Confocal Microscopy;Cytoskeleton;Data;Defect;Degenerative Disorder;Dendrites;Detection;Development;differential expression;Electroretinography;Event;experimental study;Goals;high resolution imaging;horizontal cell;Impairment;insight;Lead;LoxP-flanked allele;Measures;Mediating;Messenger RNA;Molecular;Mus;Neurodevelopmental Disorder;Neurons;novel strategies;Pathway interactions;Patients;Pattern;Phenotype;Photoreceptors;postsynaptic;presynaptic;Presynaptic Terminals;Process;protein expression;Proteins;recruit;Research;response;Retina;Retinal Cone;Retinal Diseases;retinal rods;Rod;Role;Scaffolding Protein;sight restoration;Synapses;synaptogenesis;Testing;Therapeutic;Time;Transgenic Mice;transmission process;Vertebrate Photoreceptors;Vision;Visual;visual information;Visual Pathways;Work

PROJECT_TITLE: Uncovering the role of Ankyrins in photoreceptor wiring

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative The primary goal of this project is to investigate the molecular mechanisms involved in the assembly of spinal circuits governing posture and locomotion. This study will explore the role of cell fate determinants in establishing synaptic specificity in the axial neuromuscular system and determine how developmental programs contribute to the emergence of specific motor behaviors. Defining the pathways that regulate axial motor circuit development provide basic insights relevant to the study of diseases that affect motor control, including developmental disorders in humans such as scoliosis.

PI_NAMEs: ADAMS, ALEXANDRA A (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Adult;Affect;Anatomy;Animals;Biological Assay;Breathing;Bromodeoxyuridine;Cells;Chest;Chick;Childhood;Data;Date of birth;Development;developmental disease;Disease;Electroporation;Embryo;experience;experimental study;Fishes;gain of function;Gait;Gene Expression;gene network;Generations;Genes;Genetic;Goals;Human;human disease;Immunohistochemistry;in vivo;insight;Interneurons;Knock-out;Lateral;Limb structure;Locomotion;Mammals;Maps;Medial;Modeling;Molecular;molecular subtypes;Motor;Motor Activity;motor behavior;motor control;Motor Neurons;Motor output;mouse genetics;Movement;Mus;Muscle;Musculoskeletal Equilibrium;mutant;mutant mouse model;Mutant Strains Mice;Mutation;nerve supply;neural circuit;Neural tube;neuromuscular system;Neurons;Nuclear RNA;Pathway interactions;Pattern;Play;Population;postnatal;Posture;programs;Property;rabies viral tracing;Reaction;Reporter;RNA;Role;scoliosis;single nucleus RNA-sequencing;Specific qualifier value;Specificity;Speed;Spinal;Spinal cord injury;Swimming;Synapses;System;Testing;Tetrapoda;tool;transcription factor;transcriptome sequencing;treadmill;Work;Zebrafish

PROJECT_TITLE: Elucidating the Molecular and Functional Diversity of Axial Motor Neurons

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


PHR: Project Narrative This proposal describes the training and mentoring of Mr. Nambiar and his research project to further expand and explore the applications of self-amplifying RNA (saRNA) for the treatment of solid tumors. He aims to accomplish this both by optimizing nucleoside composition and lipid nanoparticle (LNP) vehicle properties, and determining the maximum payload for saRNA (both in quantity of genes and total length of transgene). The capability of these optimizations of the saRNA-LNP platform for allowing efficient and multiplex gene expression in solid tumors will be assessed both in vitro and in vivo.

PI_NAMEs: NAMBIAR, ARUN KANNOTH (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Academia;Adjuvant Therapy;Adult;Benchmarking;cell type;Cells;chemotherapy;Chromosome Mapping;Communication;Coupled;COVID-19 vaccine;cytokine;Cytotoxic agent;Cytotoxic Chemotherapy;Data;design;Development;Drug Delivery Systems;Drug resistance;Elements;empowerment;Enzymes;experience;experimental study;Formulation;Gene Delivery;Gene Expression;gene therapy;Gene Therapy Agent;Genes;Genetic Engineering;genetic payload;Immune;Immune response;immune stimulatory agent;immunogenic cell death;immunogenicity;immunostimulatory therapy;Immunotherapy;In Vitro;in vivo;Industry;innovation;interest;Internal Ribosome Entry Site;Length;Lentivirus;lipid nanoparticle;Lipids;local drug delivery;Malignant Neoplasms;Maps;materials science;Mediating;Mentors;Messenger RNA;Methods;Modification;mRNA delivery;multidisciplinary;nanoparticle;neoplastic cell;next generation;Nucleosides;Operative Surgical Procedures;Pharmaceutical Preparations;preservation;Prodrugs;promoter;Property;Proteins;Pseudouridine;Radiation;relapse prevention;Research;Research Personnel;Research Project Grants;response;Ribosomes;RNA;RNA amplification;RNA replication;RNA Sequences;RNA-Directed RNA Polymerase;Scientist;screening;skills;Solid Neoplasm;suicide gene;synthetic biology;Technology;Testing;Therapeutic;therapeutic gene;therapeutic RNA;Thinking;Tissues;trafficking;Training;Transfection;transgene expression;Transgenes;treatment optimization;tumor;tumor heterogeneity;vector;Work

PROJECT_TITLE: Development and characterization of self-amplifying RNA Lipid Nanoparticles for potent and multiplex gene expression in solid tumors


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: CHAPEL HILL

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE  Stress-related disorders such as post-traumatic stress disorder present a substantial personal burden to affected individuals, as well as a great financial burden to taxpayers. Notably, these disorders often show changes in both interoceptive feedback and arousal. However, as the link between these processes is not well known, this project will investigate a potential mechanism for bodily feedback onto arousal regulation that has yet to be characterized.

PI_NAMEs: MILLER, NOAH WILLIAM (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Affect;Affective;Anatomy;Animal Model;antagonist;Anxiety;anxiety-like behavior;arm;Arousal;Attention;Automobile Driving;Autonomic nervous system;awake;Awareness;Behavior;Behavioral;behavioral response;Biometry;Brain;Brain region;Calcium;Cardiac;Cardiovascular system;Catecholamines;Cell Nucleus;Characteristics;Cues;Devices;Disease;Drug Modulation;Emotional;Engineering;Epinephrine;Exhibits;Exposure to;Feedback;Fiber;Financial Hardship;flexibility;Fright;Functional disorder;Grant;Heart Rate;Human;Hypertension;improved;in vivo;Individual;insight;interdisciplinary approach;Interoception;Investigation;Link;locus ceruleus structure;Measures;Mediating;Methods;Molecular Biology;Moods;Mus;Nature;neural;Neurons;neuroregulation;Neurosciences;neurotransmission;new technology;noradrenergic;Norepinephrine;Optics;optogenetics;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Photometry;Play;Post-Traumatic Stress Disorders;pre-clinical;Process;psychological stressor;Pupil;Quality of life;rate of change;Regulation;Research;response;Role;Saline;Scientist;Shapes;Signal Transduction;Site;Sotalol;Source;Stimulus;Stress;stress related disorder;Structure;System;Testing;therapeutic target;Time;Training;Travel;Vagus nerve structure;Viral;Visceral Afferents;Work

PROJECT_TITLE: Interoceptive regulation of pupil-linked arousal by connections in the brain's prominent noradrenaline hubs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Gene Therapy;Genetics;Human Genome;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: LOUISVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE Lentiviral vectors (LVVs) are Food and Drug Administration (FDA) approved for clinical use as gene delivery systems and therapeutics; however, on November 28, 2023, it was announced that all clinically approved LVV- transduced chimeric antigen receptor (CAR) T-cell therapies are under FDA investigation due to oncogenic development resulting in hospitalization or death. Current methods used for characterizing LVV integration remain limited and cannot resolve events in highly repetitive genomic regions or provide information regarding transgene intactness, making it likely that integration events are not fully described. We aim to use a novel long- read enrichment method, SMRTcap, to comprehensively characterize LVV integration profiles and transgene integrity in experimental CAR T-cells, while also evaluating the impact of these events on host gene regulation and splicing.

PI_NAMEs: KAISER, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acute Lymphocytic Leukemia;Address;Alternative Splicing;Area;B lymphoid malignancy;Biological Assay;CAR T cell therapy;CBL gene;cell envelope;Cell Nucleus;Cells;Cellular biology;Cessation of life;chimeric antigen receptor T cells;Clinical;clinical development;Clinical Trials;Clonal Expansion;Complementary DNA;Cytoplasm;Data;Dependence;Development;Disease;Disease remission;DNA;Elements;European;Event;Exons;Frequencies;gene delivery system;Gene Expression;Gene Expression Regulation;Gene set enrichment analysis;Gene Therapy Agent;Generations;Genes;Genetic Transcription;Genome;Genomic Segment;Genomics;genotoxicity;Hematopoietic Neoplasms;Hemoglobinopathies;Hospitalization;Human;Immune;Individual;Insertional Mutagenesis;insight;Integrase;integration site;Intercistronic Region;interest;Investigation;knowledge integration;Length;lentiviral integration;Lentivirus;Lentivirus Vector;life span;Ligation;Long Terminal Repeats;Lymphoma;Malignant Neoplasms;Maps;Mediating;Medicine;metaplastic cell transformation;Methods;Molecular;Multiple Myeloma;next generation sequencing;novel;Oncogenic;Outcome;Pathway interactions;Patients;Pattern;Process;promoter;Protein Isoforms;Provirus Integration;Proviruses;Reporting;Reproducibility;Resolution;Retroviridae;Reverse Transcription;Risk;RNA;RNA Splicing;Role;Safety;Sickle Cell Anemia;single molecule;single-cell RNA sequencing;Spliced Genes;success;T-Lymphocyte;Technology;Testing;Therapeutic;Time;Tissue-Specific Gene Expression;Transcription Initiation Site;Transcription Process;transgene expression;Transgenes;Translating;tumorigenesis;United States Food and Drug Administration;Untranslated Regions;vector;Viral;viral RNA;Work

PROJECT_TITLE: Comprehensive Characterization of LVV Integration and Impact on Host Cell Biology using Novel Genomic Technologies


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE In Nigeria, despite the high incidence of cervical cancer, there is low uptake of HPV vaccination among young girls and women. To bridge this research-to-practice gap, the proposed research will fill a methodological gap that impedes the translation of evidence-based HPV vaccines by developing a reliable, valid, and pragmatic Implementation Penetration Tool (IPT) to support the integration of HPV vaccines within the African context. The final development and evaluation of the IPT Tool will provide a roadmap for key stakeholders to assess actionable penetration measures within their own service settings, thereby enhancing capacity and infrastructure necessary, for advancing the adoption and sustainability of HPV vaccines in an African context.

PI_NAMEs: ANIKAMADU, ONYEKACHUKWU  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Address;Adoption;Africa;African;Age;aged;anti-cancer research;Area;Assessment tool;cognitive interview;Communities;community engaged approach;Community Healthcare;concept mapping;Country;Death Rate;design;Development;Dimensions;Elements;Evaluation;Event;evidence base;Evidence based intervention;Face;Female;Female Adolescents;Funding;girls;Goals;Government;Grant;Health Personnel;Health Professional;Healthcare;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papillomavirus;implementation science;improved;Incidence;Individual;Infrastructure;innovation;insight;interest;Intervention;Interview;Knowledge;Link;Literature;low and middle-income countries;Malignant neoplasm of cervix uteri;Measures;member;Methodology;Methods;Modeling;Morbidity - disease rate;Nature;Neighborhood Health Center;Nigeria;Nigerian;Nurses;Penetration;Perception;Performance;Physicians;pilot test;Policies;Policy Maker;Population;pragmatic implementation;prevent;Process;Property;Psychological reinforcement;Psychometrics;Public Health;Recommendation;Research;Research Personnel;research to practice;Resource-limited setting;Resources;response;routine practice;Sampling;Service setting;Site;social;Social support;Strategic Planning;Surveys;Techniques;Testing;Time;tool;Translations;uptake;Vaccinated;Vaccination;vaccine development;Validity and Reliability;Woman;young woman

PROJECT_TITLE: Implementation Penetration Assessment Criteria Tool for HPV Vaccination- Promoting Uptake among Young Girls in Nigeria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17B-K (20)]


PHR: Project Narrative This application seeks funding to support the attendance and participation of emerging investigators and those underrepresented in the sciences at the 2024 Federation of American Societies of Experimental Biology Science Research Conference on “Nutrient Sensing and Signaling in Metabolism”, held in Southbridge, Massachusetts on August 4-8, 2024. The main objective of this meeting is to promote interdisciplinary discussion and collaboration among research scientists and physician-scientists in fields related to obesity, diabetes, metabolic dysregulation, and nutritional aspects of disease across the life span.

PI_NAMEs: ANTHONY, TRACY G. (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Address;Aging;American;Amino Acids;Animals;Attention;Award;Behavior;Biology;Biomedical Research;Cachexia;Cardiovascular Diseases;career;Career Choice;career development;Caring;cell growth regulation;Cell Physiology;Cells;Child;Chronic Disease;Collaborations;collaborative environment;detection of nutrient;Development;Diabetes Mellitus;Diet;Discipline;Disease;Doctor of Philosophy;Dyslipidemias;Educational workshop;Energy Metabolism;Exercise;Family;family support;Fatty Liver;Financial Support;Food Interactions;Fostering;Funding;Gastrointestinal tract structure;glucose metabolism;Guidelines;holistic approach;Homeostasis;innovation;Insulin Resistance;interest;International;Learning;Life;life span;lipid metabolism;Liver diseases;Maintenance;Massachusetts;Measures;Mediating;meetings;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;microbiome;Mitochondria;Molecular;Muscular Atrophy;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;nutrient metabolism;nutrition;Nutritional;Obesity;Participant;personalized intervention;Pharmaceutical Preparations;Physicians;posters;Prevention;Proteins;Regulation;Request for Applications;Research;Research Personnel;response;Role;sarcopenia;Science;Scientist;Senior Scientist;Series;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;Societies;symposium;Techniques;Tissues;tool;Travel;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (M3)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Mental Health;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE Humans and other animals use sophisticated internal models of their environments to help guide their decisions. This proposal would reveal critical brain mechanisms underlying this process – in particular, how animals evaluate potential paths they could take, and how they infer that alternative paths to a reward are also worthwhile. The resulting insights into fundamental decision mechanisms would be relevant to human conditions including obsessive-compulsive disorder, which involves impaired model-based decision-making.

PI_NAMEs: BERKE, JOSHUA D (contact);DAW, NATHANIEL DOUGLASS;FRANK, LOREN M

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Acceleration;Adaptive Behaviors;Algorithms;Animals;Area;Back;Behavior;Behavioral;Brain;cell type;Cells;Chemicals;Code;Cognitive;Complex;Compulsive Behavior;Computer Models;Corpus striatum structure;Data;Decision Making;density;Distant;Dopamine;Dorsal;Electrophysiology (science);Environment;Evaluation;Event;expectation;experimental study;flexibility;frontal lobe;Future;high reward;Hippocampus;Human;Immobilization;Impairment;Influentials;innovation;insight;Learning;learning algorithm;learning network;Location;Maps;Medial;Mediating;Methods;Modeling;Monitor;neural;neuromechanism;Neurons;novel;Obsessive-Compulsive Disorder;optogenetics;Outcome;Pattern;Phase;Play;Population;Positioning Attribute;Process;Psychological reinforcement;Rattus;Recording of previous events;Retrieval;Rewards;Role;Running;Signal Transduction;simulation;Statistical Methods;Techniques;Technology;temporal measurement;Testing;Theta Rhythm;Time;Update;Ventral Striatum

PROJECT_TITLE: Value networks and hippocampal non-local representations

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Eye Disease and Disorders of Vision;Genetics;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: AUGUSTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

PHR: PROJECT NARRATIVE Keratoconus (KC), a progressive and degenerative disorder characterized by localized thinning near or in the center of the cornea, affects an estimated 300,000 people in the United States and is one of the leading causes of corneal transplant. This project seeks to determine how the interaction of KC-associated environmental and genetic risk factors in vivo and in vitro contributes to the development of KC. Successful completion of this project will provide not only in vivo animal and in vitro multi-cellular models for KC but also an advanced understanding of the interplay between genetic and environmental risk factors and how they contribute to KC development.

PI_NAMEs: HADVINA, RACHEL  (contact)

PROJECT_TERMS: Academic Training;Acute;Affect;American;Animal Model;Animals;Astigmatism;atopy;Biological Markers;Biomechanics;Blinking;C57BL/6 Mouse;Candidate Disease Gene;career development;Cell Membrane Permeability;Cell model;cell type;Cells;Characteristics;Chromatin;Chronic;Collagen;Complex;Cone;Cornea;Corneal Diseases;corneal epithelium;Corneal Injury;corneal scar;crosslink;Data;Defect;Degenerative Disorder;Development;diphosphoinositol pentakisphosphate kinase;Disease;Disease Progression;Disease susceptibility;Dose;Economic Burden;effective therapy;Environmental Risk Factor;Epithelial Cells;Epithelial-Stromal Communication;Epithelium;Etiology;experience;Experimental Designs;experimental study;Exposure to;Extracellular Matrix;Eye;Family;Fibroblasts;follow-up;gene environment interaction;Generations;Genes;Genetic;genetic analysis;genetic risk factor;Goals;Histology;Human;In Vitro;in vitro Model;in vivo;in vivo Model;Inflammatory;Inflammatory Response;innovation;intercellular communication;interest;Interleukin-6;irradiation;Keratoconus;Keratoplasty;Knock-in Mouse;Light;Measurement;Mechanics;Membrane;Modeling;Molecular;Monitor;monolayer;Morphology;mouse model;Mus;Mutation;novel;novel therapeutics;Operative Surgical Procedures;organ on a chip;Outcome;Pathogenesis;Pathology;Patients;Periodicity;Persons;Phenotype;Physiologic pulse;Physiological;Porosity;Process;Progressive Myopia;response;Risk Factors;Shapes;slit lamp imaging;Stains;Stretching;Stromal Cells;Sun Exposure;System;Testing;therapeutic target;Thick;Thinness;Tissue-Specific Gene Expression;Tissues;TNF gene;TNFSF5 gene;Ultraviolet A radiation;Ultraviolet B Radiation;Ultraviolet Rays;United States;UV Radiation Exposure;Vision Disorders;Work

PROJECT_TITLE: Interaction of Genetic and Environmental Factors in Keratoconus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


NIH_SPENDING_CATS: Diabetes;Genetics;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Type 2 diabetes is a disease of relative β-cell dysfunction that affects >400 million people worldwide. We recently used orthogonal approaches and discovered discrete β-cell subsets that are functionally and epigenetically distinct from one another. Here, we will define how these putative β-cell subtypes function, how epigenetic mechanisms control their emergence, and whether their selective manipulation can reverse pathology in mouse models of diabetes.

PI_NAMEs: POSPISILIK, JOHN ANDREW (contact);RUTTER, GUY ALLEN

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Affect;Agonist;Beta Cell;biobank;Cell Compartmentation;Cell Lineage;Cell surface;Cell Surface Proteins;Cells;Chromatin;clinically relevant;Compensation;Data;data integration;Development;Diabetes Mellitus;Diabetic mouse;Diet;Disease;dosage;Epigenetic Process;epigenome;epigenomics;Etiology;Exhibits;experimental study;Functional disorder;Gap Junctions;Genetic Transcription;genetic variant;Glucose;Heterogeneity;Human;human stem cell-derived;human stem cells;Image;in silico;In Vitro;in vivo;inhibitor;innovation;insulin secretion;islet;islet stem cells;Measures;Metabolic Diseases;Methodology;Methods;Mitochondria;Morphology;mouse model;Mus;mutant;Mutation;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear;Obesity;Pancreas;Pancreatic Diseases;Pathology;Patients;Pattern;Persons;Population;Property;protein expression;response;Sampling;Series;Specific qualifier value;Structure of beta Cell of islet;System;Testing;Time;tool;trait;transcriptome;transplantation therapy

PROJECT_TITLE: Understanding putative beta-cell subtypes

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Aging;Bioengineering

PHR: Project Narrative NAD Signaling and Metabolism is central to human biology; mediating key aspects of healthy physiology and aging but can be usurped in diseases such as cancer. The Federation of American Societies of Experimental Biology (FASEB) sponsors a biennial conference that unites researchers and clinicians with shared interest in understanding NAD-dependent mechanisms and in evaluating the potential of this molecule for improving human health. With this R13 application, we seek funding to support attendance and increase engagement of highly meritorious early-stage scientists and trainees.

PI_NAMEs: CAMBRONNE, XIAOLU ANG (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TITLE: NAD Metabolism and Signaling


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This research will contribute fundamental knowledge about how primates perceive and interact with the three- dimensional (3D) world. In the short term, it will reveal how ecologically relevant representations of the world are created from ambiguous sensory signals and in the long term provide insights for treating neurological disorders, brain injury, and cognitive dysfunction. Because 3D vision is a major component of virtual and augmented reality, the public health relevance of this work extends to industry which faces growing demands to develop devices that are safe, persuasive, inclusive, and have therapeutic value.

PI_NAMEs: ROSENBERG, ARI  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: 3-Dimensional;3D world;Area;area striata;Association Learning;Attention;Automobile Driving;Behavior;Behavioral;behavioral outcome;Brain;Brain Injuries;Chronic;Data;density;Devices;discrimination task;electrical microstimulation;Electrophysiology (science);Evolution;expectation;experimental study;Eye Movements;Face;flexibility;Human;Impaired cognition;Individual;Industry;Injections;insight;interest;Knowledge;Learning;Linear Regressions;Link;Macaca;Measures;Memory;Modeling;Monkeys;Muscimol;Nervous System Disorder;neural circuit;Neurodevelopmental Disorder;Neurons;novel;Occipital lobe;oculomotor;orientation selectivity;Parietal Lobe;Perception;Performance;Positioning Attribute;preference;pressure;Prevalence;Primates;Process;Property;public health relevance;Reporting;Research;response;Retina;retinal imaging;Role;Saccades;sample fixation;Sensory;Shapes;Side;Signal Transduction;Site;Stimulus;Structure;Surface;Synapses;System;Systematic Bias;Techniques;Testing;Therapeutic;Training;two-dimensional;Virtual and Augmented reality;Vision;Visual;Visual Cortex;visual map;Visual Perception;Visual System;Visuospatial;Work

PROJECT_TITLE: Hierarchical cortical circuitry supporting 3D visual perception and oculomotor function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-A (02)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: LINCOLN

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: Project Narrative  High rates of alcohol-involved sexual violence (SV) victimization and adverse health outcomes (e.g., psychological distress, poor coping strategies) among women poses a significant public health problem. Novel etiological models aimed at understanding victimization risk for alcohol-involved SV can increase the efficacy of risk reduction strategies. The proposed project will use an 8-week electronic daily diary design to examine how alcohol-motivated restricted eating and alcohol use contribute to acute alcohol intoxication and SV victimization among a sample of young adult women.

PI_NAMEs: BAILDON, AMANDA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Acute;Address;Adult women;adverse outcome;alcohol abstinence;Alcohol consumption;alcohol effect;alcohol involvement;alcohol myopia;alcohol related consequences;alcohol risk;Alcoholic Intoxication;Alcohols;Area;assault;Attention;Behavioral;Calories;Communities;Consumption;Coping Skills;Cues;design;Development;diaries;drinking;Eating;Educational Curriculum;Electronics;Ensure;ethnic identity;Etiology;Evaluation;experience;Exposure to;familial amyotrophic lateral sclerosis;food consumption;food restriction;Goals;Health;injured;innovation;Intervention;Intoxication;Literature;longitudinal design;Measures;men;Methodology;Modeling;motor impairment;novel;Outcome;Participant;Patient Self-Report;Peer Group;Perception;perpetrators;Persons;Physiological;Play;pressure;prevent;Prevention strategy;Process;programs;psychological distress;Public Health;racial identity;recruit;Research;Resources;Risk;Risk Factors;Risk Reduction;Role;Sampling;Series;Sex Orientation;sexual risk reduction;sexual violence;Sexual violence prevention;skills;social;social culture;Somatotype;Stereotyping;Testing;theories;Thinness;Time;Training;United States;Victimization;violence perpetration;violence victimization;Weight Gain;Woman;Work;young adult

PROJECT_TITLE: A Daily Assessment of Restricted Food Consumption and Alcohol Intoxication as Predictors of Sexual Violence

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE This project seeks to non-invasively estimate patient-specific myocardial stiffness via computational means in patients with heart failure with preserved ejection fraction (HFpEF). As a result, this work will help elucidate deeper insights into how myocardial stiffness changes over the course of HFpEF. Such knowledge could help physicians stratify patients into risk groups and devise management plans that are optimal for each patient as well as predicting HFpEF in the long-term, ultimately improving clinical outcomes and enhancing their quality of life.

PI_NAMEs: HUSSEIN, TAWFIK  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: 3-Dimensional;Age;Area;Biomechanics;Blood;Cardiac;cardiac magnetic resonance imaging;Cardiology;Clinical;clinical imaging;Clinical Trials;comparison control;Complex;Computer Models;Control Groups;Cross-Sectional Studies;Data;Development;Diagnosis;Echocardiography;EFRAC;Etiology;exercise capacity;Fiber;Functional disorder;Goals;Heart;Heart failure;heart imaging;Heterogeneity;Image;imaging modality;improved;indexing;Individual;innovation;insight;Institution;Knowledge;Magnetic Resonance Imaging;Measurement;Measures;Methods;Modeling;Monitor;multi-scale modeling;Myocardial;Myocardium;novel;novel strategies;Outcome;Pathologic;patient stratification;Patients;Physicians;Positioning Attribute;preservation;Prognosis;Property;Publications;Pulmonary Circulation;Quality of life;Radial;recruit;Relaxation;Reproducibility;Research;Research Training;Risk;risk stratification;Sensitivity and Specificity;Shortness of Breath;Signs and Symptoms;simulation;Specificity;Symptoms;Syndrome;Techniques;Therapeutic Agents;translational impact;treatment optimization;treatment planning;ultrasound;Ventricular;Work

PROJECT_TITLE: A Multiscale Computational Model of the Heart for Patient-specific Diagnosis of HFpEF

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-B (20)]


NIH_SPENDING_CATS: Biotechnology;Cystic Fibrosis;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Liver Disease;Lung;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE  Inhaled gene therapy holds promise for the treatment of genetic lung diseases. However, immune responses in the lung are likely to present a barrier to effective treatment and prevent drug re-administration. The goal of this proposal is to understand these responses and attempt to ameliorate them by repurposing FDA-approved immunomodulatory agents.

PI_NAMEs: CLARK, ROBERT DAVID EDWARD (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: adeno-associated viral vector;adenovirus mediated delivery;Adenovirus Vector;Adoptive Transfer;Animal Model;Antibodies;Antibody Response;Antigen-Presenting Cells;Antigens;Attenuated;B-Lymphocytes;bench to bedside;Biological Assay;bioluminescence imaging;Capsid;career;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;cellular transduction;Chloride Channels;Clinical Trials;clinically relevant;Cross Presentation;Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;delivery vehicle;Dendritic Cells;Development;Disease;Dose;effective therapy;Eligibility Determination;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Epithelium;experience;Failure;FDA approved;Flow Cytometry;Fungal Antigens;Gene Delivery;Gene Expression;gene therapy;Gene Transfer;gene-targeted therapy;Generations;Genes;Genetic;Genotype;Goals;Human;immune modulating agents;Immune response;Immunity;Immunoglobulin G;Immunoglobulins;Immunologic Memory;Immunologic Stimulation;Immunologics;immunoregulation;In Vitro;in vivo;Individual;Inhalation;Life;Liver;Liver diseases;Lung;Lung Diseases;Lung Transplantation;Lymphangioleiomyomatosis;Measures;Mediating;Memory;Mucosal Immune Responses;Mucous Membrane;Mus;Muscle;Mutation;Mycoses;Myopathy;next generation;Pharmaceutical Preparations;Physicians;Play;prevent;Primary Ciliary Dyskinesias;Property;pulmonary arterial hypertension;Pulmonary Cystic Fibrosis;pulmonary function;Recovery;Regulatory T-Lymphocyte;Research;respiratory;Respiratory System;response;restoration;Role;Safety;Scientist;Secretory Immunoglobulin A;seropositive;Serum;side effect;single-cell RNA sequencing;success;T cell response;T memory cell;Testing;Therapeutic;Training;transgene expression;Treatment Effectiveness;Tropism;vector;Virus-like particle;Work

PROJECT_TITLE: Overcoming Immunological Barriers to Inhaled AAV Gene Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


NIH_SPENDING_CATS: Cardiovascular

PHR: Project Narrative High levels of blood triglycerides are a risk factor for cardiovascular disease in humans, so new ways to manage blood triglycerides are needed. Lipoprotein lipase (LPL) is an essential enzyme for the clearance of triglycerides from the blood. This project aims to determine the trafficking pathways and subcellular localization of two LPL inhibitors, angiopoietin-like (ANGPTL) protein 3 and ANGPTL8, which could lead to ways to boost the activity of LPL by blocking its inhibition.

PI_NAMEs: SO, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Adipose tissue;Alleles;Angiopoietins;ANGPTL3 gene;Antibodies;Biological Assay;Biotin;Blood;Blood Circulation;Cardiovascular Diseases;cardiovascular risk factor;Cells;Chylomicrons;Complex;Confocal Microscopy;Coronary Arteriosclerosis;Dangerousness;Data;Disease;Drug Design;Early Endosome;Endoplasmic Reticulum;Enzymes;experimental study;Fluorescence Microscopy;Future;genome wide association study;Golgi Apparatus;Human;Hydrolysis;Hypertriglyceridemia;Image;In Vitro;in vitro Assay;in vivo;Incidence;Individual;inhibitor;insight;Kinetics;late endosome;lipid metabolism;Lipids;lipoprotein lipase;lipoprotein lipase inhibitor;Lipoproteins;Liver;loss of function;Lysosomes;multicatalytic endopeptidase complex;Mus;Mutant Strains Mice;Nonesterified Fatty Acids;Nutritional;Organelles;Pathway interactions;Pattern;pharmacologic;Plasma;prevent;Proteasome Inhibitor;Proteins;Regulation;Serum;Signal Transduction;Skeletal Muscle;Streptavidin;streptavidin-binding peptide;System;Testing;Time;Tissues;trafficking;Triglycerides;uptake;Very low density lipoprotein;Visualization;Western Blotting

PROJECT_TITLE: Mechanism of Intracellular ANGPTL3 and ANGPTL8 Trafficking

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: STILLWATER

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: PROJECT NARRATIVE Idiopathic pulmonary fibrosis (IPF) afflicts approximately 3 million individuals worldwide, and an estimated 40,000 people succumb to the disease each year in the United States. Achieving the goals of this project will lead to the discovery of new molecules and pathways that modulate fibroblast activation and thus provide insights toward the development of effective therapies for IPF.

PI_NAMEs: LIU, LIN  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: 3' Untranslated Regions;Actins;Advanced Development;Anemia;Area;Asbestos;Binding;Bleomycin;Chronic lung disease;cigarette smoke;Co-Immunoprecipitations;Development;Diagnosis;Disease;Down-Regulation;effective therapy;Elements;Etiology;Family;FDA approved;Fibroblasts;fibrotic lung;gain of function;gene therapy;Genes;Genetic;genetic manipulation;Genetic Transcription;genome-wide;Goals;homeodomain;Homeostasis;Human;idiopathic pulmonary fibrosis;In Vitro;in vivo;Individual;Inhalation;inhibitor;insight;Invaded;Ions;Iron;Iron Chelation;iron supplementation;Iron-Regulatory Proteins;kidney fibrosis;knock-down;loss of function;Lung;Mediating;member;Messenger RNA;Modeling;Molecular;mouse development;mouse model;mRNA Stability;Mus;Mutagenesis;Names;novel;overexpression;Particulate Matter;Pathogenesis;Pathway Analysis;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;pre-clinical;Process;Protein Kinase Interaction;Proteins;Pulmonary Fibrosis;Regulation;Ring Finger Domain;Risk Factors;Role;SH3 Domains;Signal Pathway;Smooth Muscle;solute;Stress Fibers;Testing;Translations;Treatment Efficacy;ubiquitin-protein ligase;Ubiquitination;United States;Up-Regulation

PROJECT_TITLE: The Role of Iron In Pulmonary Fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE  The proposed research will investigate how the dynamics of a RNA chaperone protein and its RNA ligands are mutually rewired to expedite gene regulation in bacteria. Understanding this rewiring of dynamics is crucial for developing next-generation antimicrobials that target bacterial virulence.

PI_NAMEs: WHITE, ELISE  (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Acceleration;Affect;antimicrobial;Arginine;Bacteria;Base Pairing;Binding;Binding Sites;biological adaptation to stress;Biological Assay;biophysical techniques;Biophysics;C-terminal;career development;Communication;Communities;Complex;Computer Simulation;computerized tools;conformational conversion;Development;Diffuse;Diffusion;Dimensions;Discrimination;Disease;Doctor of Philosophy;Energy Transfer;experimental study;flexibility;Gene Expression;Gene Expression Regulation;Goals;Image;insight;instrumentation;Kinetics;Knowledge;Label;Lateral;Ligands;Mediating;Mentors;Messenger RNA;Methods;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;molecular dynamics;Monitor;Motion;mutant;next generation;NMR Spectroscopy;Nuclear Magnetic Resonance;Process;programs;protein complex;Proteins;Regulation;Relaxation;Research;Resources;response;restraint;RNA;RNA Binding;RNA Sequences;RNA-Binding Proteins;Role;Sampling;Scanning;Signal Transduction;simulation;single molecule;Site;skills;Slide;statistics;Students;Techniques;Testing;Training;Transcript;Translations;Universities;Untranslated RNA;Variant;Virulence;Visualization

PROJECT_TITLE: Modeling Hfq-RNA Dynamics on an Atomistic Scale

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04B-S (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Contraception/Reproduction;Estrogen;Mental Health;Mental Illness;Neurosciences;Pediatric;Psychosis;Schizophrenia;Serious Mental Illness;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative During the transition from childhood to adolescence, psychosis vulnerability may interact with substantial brain and hormone development contributing to the emergence of psychotic-like experiences (PLEs). Growing evidence suggests that estrogen levels, which begin to significantly differentiate between male and female sex during this transition, play an important role in modulating the liability to psychosis, but their impact on brain, cognition, and symptoms have not been examined in this critical developmental period. This study utilizes extant data from the Adolescent Brain Cognitive Development (ABCD) Study to examine these associations with the goal of providing novel mechanistic understanding and improving detection and novel treatments.

PI_NAMEs: DAMME, KATHERINE STEFFEN FILIP;MITTAL, VIJAY A (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent brain development;Adolescent Development;Adult;Affect;Age at Menarche;Biological;Biological Assay;biological sex;Biometry;Brain;Child;Childhood;Clinical;Cognition;Cognitive;Cognitive deficits;cognitive development;cognitive function;cognitive testing;Coupled;critical developmental period;Data;Data Set;Delusions;Detection;Development;early adolescence;Estradiol;Estrogen decline;Estrogens;Female;Generations;Goals;Growth;Hippocampus;Hormonal;Hormonal Change;Hormones;improved;Individual;individual variation;insight;interest;Intervention;Investigation;Literature;longitudinal course;male;Memory impairment;Menarche;Modeling;Natural experiment;Nature;neural;neurodevelopment;neuroimaging;novel;Participant;Pathologic;Pattern;Performance;phenomenological models;Play;psychological symptom;Psychoses;psychosis risk;Psychotic Disorders;psychotic-like experiences;Puberty;Research;Rest;Role;Sampling;Schizophrenia;Severities;sex;Short-Term Memory;Site;Specificity;Structure;Subgroup;Symptoms;Synapses;Syndrome;Testing;theories;Time;translational applications;Work;Youth

PROJECT_TITLE: Estrogen and Mechanisms of Psychotic-like Experiences in the Transition to Adolescence

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Estrogen;Heart Disease;Women's Health Research

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Aortic valve stenosis affects ~13% of the US population over 75 years of age and interestingly men have a two- fold higher risk for developing calcified valves whereas women tend to present with severely fibrotic valves. This proposal aims to investigate these sex differences, particularly the dynamic interplay between sex-specific immune cell (macrophage) interactions with resident valve interstitial cells (VICs) and how they lead to aortic valve stenosis sexual dimorphism. Our approach includes the 3D culture of VICs and macrophages in hydrogel matrices to identify the effects of secreted factors and direct contact on their phenotype and function, toward revealing targets for sex-specific, non-surgical (e.g., pharmaceutical) therapies.

PI_NAMEs: KHANG, ALEX  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Age Years;alternative treatment;Anti-Inflammatory Agents;Anticoagulation;aortic valve;Aortic Valve Stenosis;Behavior;Biological;biological sex;Biotechnology;calcification;career;Cell Communication;Cell Line;cell motility;Cell secretion;Cells;Cellular Structures;Coculture Techniques;Collaborations;Collagen;Colorado;cytokine;Deposition;Development;Disease;Disease Progression;druggable target;Elderly;Endothelial Cells;Engineering;Equipment;Event;experimental study;Faculty;Female;Fibroblasts;Fibrosis;Funding;Genes;Germ Cells;healing;Heart Valve Diseases;high risk;Hydrogels;Immune;immune cell infiltrate;Immune response;Immunology;In Vitro;in vitro Model;in vivo;Infiltration;Inflammation;Inflammatory;insight;Interleukin-1 beta;Interleukin-10;Interleukin-6;interstitial cell;Knowledge;Lead;light microscopy;Macrophage;male;Measurement;mechanotransduction;member;men;Mentorship;Microscopy;mimetics;Modeling;Molecular;Monitor;Myofibroblast;Operative Surgical Procedures;Osteoblasts;personalized medicine;Pharmacologic Substance;Phenotype;Phenotypic Sex;Play;Population;Process;Progressive Disease;recruit;Reporting;Research;Research Personnel;Role;Severity of illness;sex;Sex Differences;sexual dimorphism;Surface;symposium;Testing;three dimensional cell culture;Three-Dimensional Imaging;Time;Tissues;TNF gene;Traction Force Microscopy;Training;Undifferentiated;Universities;valve replacement;Woman;Work;X Inactivation

PROJECT_TITLE: Identifying the Role of Fibroblast-Macrophage Crosstalk in Aortic Valve Stenosis Sexual Dimorphism


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Twin-to-Twin Transfusion Syndrome (TTTS) is a serious complication of twin pregnancies, affecting up to 15% of twins sharing the same placenta (monochorionic twins) with dismal outcomes without intervention. Although fetoscopic laser photocoagulation of the associated placental anastomoses has improved outcomes, losses and compromised outcomes remain high. We propose to develop novel magnetic resonance imaging (MRI) approaches to improve presurgical planning, directly assess placental function and more closely monitor fetal growth with the overall goal to improve outcomes.

PI_NAMEs: ADALSTEINSSON, ELFAR ;GRANT, PATRICIA ELLEN (contact);SHAMSHIRSAZ, ALIREZA

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: 3-Dimensional;Abdomen;Ablation;Address;Affect;Aftercare;Amniotic Fluid;Anastomosis - action;automated segmentation;Ballistics;Biometry;Birth Weight;Bladder;Blood;Blood donor;Blood flow;Blood Vessels;body volume;Cerebral Palsy;Clinical Research;Compensation;Complication;Computer Models;Development;Diagnosis;Echo-Planar Imaging;Evaluation;Exposure to;fetal;Fetal Growth;Fetal health;Fetal Monitoring;Fetofetal Transfusion;Fetus;follow-up;Functional disorder;Gestational Age;Goals;Hyperoxia;Hypoxia;Image;imaging approach;improved;improved outcome;innovation;insight;Intervention;Joints;laser photocoagulation;Laser Surgery;Lasers;Length;Limb structure;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methods;Monitor;Motion;Natural History;Neonatal;neural network;Neurodevelopmental Impairment;novel;Operative Surgical Procedures;Outcome;Oxygen;oxygen transport;Pathology;Perfusion;Perinatal;Placenta;Postoperative Period;Pregnancy;Pulsatile Flow;reconstruction;response;Risk;Series;Severities;statistics;Surface;Surgeon;Techniques;Time;tool;Trees;Twin Multiple Birth;ultra high resolution;Ultrasonography;ultrasound;Umbilical cord structure;Umbilicus;Uterus;vascular abnormality;Venous;Villous;Visualization;Weight;Work

PROJECT_TITLE: Developing novel MR tools to optimize surgical planning and fetal outcome in TTTS

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Transplantation

PHR: PROJECT NARRATIVE The healing of large bone defects, greater than the intrinsic capacity of self-regeneration, remains a significant clinical challenge with approximately 500,000 patients undergoing bone transplants each year in the US alone. Natural fracture healing involves a coordinated series of biological events, including inflammation, vascularization, and osteogenesis, precisely orchestrated in time and space, to repair and regenerate bone tissue. The proposed research aims to develop an innovative biomaterial approach in which granular hydrogels are used to manipulate the regenerative secretome, specifically extracellular vesicles (EVs), of bone marrow- derived mesenchymal stem/stromal cells and then subsequently engineered to serve as delivery vehicles for the local presentation and sustained release of EVs in vivo to promote bone tissue regeneration in critical-sized bone defects.

PI_NAMEs: FRIEND, NICOLE ERIN (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Alkynes;Allogenic;Amides;analog;Angiogenic Factor;Anti-Inflammatory Agents;Apoptosis;Autologous;Azides;Biocompatible Materials;Biological;bioscaffold;blood vessel development;Blood Vessels;BMP2 gene;bone;Bone callus;Bone Diseases;bone fracture repair;bone healing;Bone Marrow;bone quality;Bone Regeneration;Bone Substitutes;Bone Tissue;Bone Transplantation;Calvaria;cell assembly;Cell Communication;Cell secretion;Cell Survival;cell type;Cells;cellular imaging;Cellular Infiltration;Chemistry;Chronic Disease;Clinical;Communicable Diseases;Complex;controlled release;cycloaddition;Data;Defect;delivery vehicle;design;Development;Diffusion;Dose;Encapsulated;Endothelial Cells;Engineering;Engraftment;Enzyme-Linked Immunosorbent Assay;Esters;ethylene glycol;Event;Excision;experience;Extracellular Matrix;extracellular vesicles;Feedback;Fibroblast Growth Factor;Fracture;Gel;Genomics;Glycoengineering;Growth;healing;Hematoma;Histology;Hydrogels;Immune;immune cell infiltrate;Immune response;immunogenic;immunoregulation;Implant;improved;In Vitro;in vivo;in vivo regeneration;Individual;Inflammation;Inflammatory Response;Injury;innovation;Interleukin-10;Interleukin-13;Interleukin-4;Invaded;live cell imaging;Longitudinal Studies;Macrophage;Mesenchymal;microCT;Microscopy;mineralization;Modeling;Monitor;Morbidity - disease rate;Morphogenesis;Natural regeneration;Nutrient;Operative Surgical Procedures;Osteogenesis;osteoinductive factor;Pain;Patients;Pericytes;Phenotype;Population;Population Heterogeneity;Porosity;pre-clinical;Process;Production;Property;Proteins;Proteomics;Rattus;Reaction;regeneration potential;regenerative;Regenerative Medicine;repaired;Research;Research Personnel;response;Reverse Transcriptase Polymerase Chain Reaction;scaffold;Secretory Cell;Series;Site;Small RNA;Source;standard care;stem;Stimulus;Stromal Cells;subcutaneous;superresolution imaging;Techniques;Testing;Therapeutic;Time;time use;Tissue Engineering;tissue regeneration;Tissues;transcriptome sequencing;Transplantation;Traumatic injury;tumor;Vascular Endothelial Growth Factors;Vascularization;vesicular release;Western Blotting;Work

PROJECT_TITLE: Granular hydrogels for the controlled delivery of immunomodulatory and angiogenic extracellular vesicles to enhance bone tissue regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pain Research;Social Determinants of Health

PHR: Project Narrative Low-wage workers are more likely to have chronic pain-related conditions and yet less likely to take advantage of work accommodations, contributing to the cycle of chronic health problems and unemployment. This study aims to assess how employer-level and worker-level factors influence the utilization of work accommodations. Findings will help determine breakdowns in the system and inform policy shifts aimed at optimizing the use of work accommodations to help low-wage workers maintain employment and mitigate chronic conditions.

PI_NAMEs: MCARTHUR, RANDI  (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Address;Adult;Affect;American;Area;autism spectrum disorder;career;Chronic;Chronic Disease;chronic pain;cost;Data;demographics;design;disability;Disabled Persons;Discrimination;Disparity population;Economics;Education;Eligibility Determination;Employee;Employment;Equity;Ethnic Origin;experience;Face;Fibromyalgia;Foundations;Frequencies;Fright;Future;Goals;Group Processes;Health;health care availability;health equity;health inequalities;Health Insurance;High Prevalence;Impairment;improved;Incidence;Individual;Inequity;Injury;Intervention;Job loss;Knowledge;Lead;Legal;Light;Mediation;Mental disorders;Methods;Migraine;Morbidity - disease rate;mortality;Nature;Nurses;Occupational;Occupations;Outcome;Pain;Personal Satisfaction;Persons;Phase;physically handicapped;Play;Policies;Population;Positioning Attribute;Prevalence;Process;Productivity;professional atmosphere;programs;Psyche structure;psychological distress;Quality of life;Race;Reporting;Research;Research Design;Research Methodology;Research Personnel;Risk;Role;Science;Scientist;Security;Severities;Sick Leave;skills;social health determinants;social stigma;Strategic Planning;symptom management;System;Time;Unemployment;United States;Vulnerable Populations;Wages;Work;Workplace

PROJECT_TITLE: Exploring Work Accommodations for Low-Wage Workers with Chronic Pain-Related Conditions: A Multi-Level Explanatory Sequential Mixed-Methods Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZNR1 REV-N (05)]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE  Over 300,000 people in the United States suffer from spinal cord injury (SCI). Heightened sympathetic reflexes drives the development of secondary consequences post-SCI, such as cardiovascular disease and infection, two of the leading causes of morbidity and mortality within this population. This proposal will investigate whether the loss of receptor cation-chloride cotransporter type 2 (KCC2) contributes to the development sympathetic hyperreflexia and whether SCI-induced changes in KCC2 expression post-injury is mediated by NF-B.

PI_NAMEs: WULF, MARIAH J (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Affect;Animals;Atrophic;Attenuated;Autonomic Dysreflexia;Cardiovascular Diseases;cardiovascular infection;Cations;Central Nervous System;Chest;Chlorides;clinically relevant;Complex;conditional knockout;cytokine;Data;Development;Disease;Down-Regulation;Enhancers;Functional disorder;functional improvement;Goals;Health;Homeostasis;Hyperreflexia;Hypertension;Immune System Diseases;Immunosuppression;improved;Individual;Infection;Inflammatory;influenza infection;inhibitor;Injury;Knowledge;Laboratory Finding;Lesion;Life;Mediating;Membrane;Morbidity - disease rate;mortality;Motor;mouse model;Mus;neural circuit;neuroinflammation;Neurons;neuropathology;Organ;Peripheral;Persons;Physiological;Play;Population;Predisposition;receptor;Reflex action;Regulation;Reliability of Results;response;Role;sensory stimulus;Severities;Signal Transduction;Spinal;Spinal cord injury;Spleen;symporter;synaptic inhibition;System;Testing;theories;Therapeutic;therapeutic target;Time;transcription factor;United States

PROJECT_TITLE: Role of KCC2 in sympathetic dysfunction after spinal cord injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]