NIH_SPENDING_CATS: Cardiovascular;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emergency Care;Heart Disease;Lung;Pediatric;Physical Injury - Accidents and Adverse Effects

ORG_CITY: SALT LAKE CITY

PHR: Project Narrative Resuscitation from critical illness requires skillful delivery of oxygen. This project will compare three paramedic strategies for delivering life-saving oxygen to critically-ill children. The findings will improve public health by defining approaches to improve survival and reduce years of life loss among critically-ill children.

PI_NAMEs: VANBUREN, JOHN  (contact)

PROJECT_TERMS: Adoption;Adult;Age;Biometry;Bradycardia;Brain;Caring;Categories;Chest;Child;Child Care;Childhood;Childhood Injury;Clinical;clinical trial analysis;Clinical Trials;Communication;Complement;Critical Illness;Critically ill children;Data;Data Collection;Data Coordinating Center;data management;Data Set;design;Devices;disorder subtype;emergency settings;Enrollment;evidence base;experience;feasibility trial;Gel;Generations;Goals;Guidelines;Heart;Heart Arrest;Hospitals;Human Resources;Hyperventilation;Hypoxia;improved;improved outcome;innovation;Interruption;Intratracheal Intubation;Laryngeal Masks;Larynx;Leadership;Life;Lung;Maintenance;Manuals;Masks;Methods;Monitor;multidisciplinary;novel;operation;out-of-hospital cardiac arrest;Oxygen;Paramedical Personnel;patient population;Patients;pediatric emergency;pragmatic trial;Pre-hospitalization care;Preparation;prevent;Production;Protocols documentation;Public Health;Qualifying;Recommendation;relative effectiveness;Reporting;Research;Research Personnel;Respiratory Failure;Resuscitation;severe injury;skills;Solid;study population;Survival Rate;Technical Expertise;Techniques;Testing;Training;Trauma;Traumatic injury;trial design;Tube;United States Agency for Healthcare Research and Quality;Universities;Utah;ventilation;years of life lost

PROJECT_TITLE: 2/2: Pediatric Prehospital Airway Resuscitation Trial (Pedi-PART)

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Gene Therapy;Genetics;Immunotherapy;Nanotechnology;Women's Health Research

ORG_CITY: DAVIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SURGERY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: NARRATIVE The limited ability to monitor the infused CAR T cells’ location and activity in real-time contributes to less efficient  therapy and more systemic side effects. This proposal seeks to develop an image-guided therapy and activity  monitoring/controlling system based on the combination of nanotechnology, combined ultrasound and  photoacoustic imaging, and cell engineering to increase treatment precision and decrease side effects.

PI_NAMEs: KIM, JINHWAN  (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Ablation;absorption;Address;Adverse effects;Aftercare;Algorithms;Anatomy;Animals;aptamer;Binding;Biological;Biological Markers;Biological Process;Biosensor;Blood flow;Breast Cancer Model;cancer immunotherapy;cancer type;CAR T cell therapy;career;career development;cell behavior;Cell Physiology;Cell surface;Cell Survival;Cells;cellular engineering;cellular imaging;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Collaborations;contrast imaging;Contrast Media;cytokine;cytokine release syndrome;design;Detection;Development;Disease;DNA;Doctor of Medicine;Doctor of Philosophy;Dose;engineered T cells;Engineering;Exhibits;experimental study;Foundations;Goals;Granzyme;Histologic;Hydroquinones;Image;image guided;image guided therapy;imaging agent;imaging system;Imaging Techniques;Imaging technology;Immune;Immunotherapeutic agent;improved;In Vitro;in vivo;Infiltration;Infusion procedures;innovation;instrumentation;Interferon Type II;Interleukin-2;Interleukin-6;Knowledge;Label;Lasers;leukemia;Life;Location;Maleimides;Malignant Breast Neoplasm;Malignant Neoplasms;manufacture;Medical Imaging;Medicine;Mentors;Mentorship;Methods;mid-career faculty;miniaturize;Modification;Monitor;mouse model;multidisciplinary;nanobiomaterial;nanoGold;nanomaterials;nanoparticle;nanorod;nanosensors;Nanosphere;Nanotechnology;neurotoxicity;Oncology;Optics;Oxygen;Phase;photoacoustic imaging;Physiologic pulse;plasmonics;Precision therapeutics;Prediction of Response to Therapy;preservation;prevent;professor;Program Development;programs;Reaction Time;remote control;remote sensing;Research;Research Personnel;Resolution;response;Scientist;sensor;side effect;Signal Transduction;Site;Solid Neoplasm;Sulfhydryl Compounds;Surface;System;T-Cell Receptor Therapy;T-Lymphocyte;Therapeutic;therapy outcome;Time;Tissues;Training;Translating;Translations;Treatment outcome;tumor;tumor immunology;tumor microenvironment;Ultrasonography;ultrasound;Universities;Urology

PROJECT_TITLE: Nanoparticle-augmented image-guided CAR T therapy and post-treatment assessment

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Pain Research;Palliative Care;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: COMPLETE Project Narrative This prospective cluster-randomized trial examines the efficacy of an early palliative care-based communication intervention delivered by trained physician and nurse dyads, to parents of children with cancer within their practice, to foster alignment of the goals of treatment when cure is unrealistic. We hypothesize that goal alignment will facilitate hospice enrollment, lessen use of high-intensity medical interventions, pain and emotional distress in children and reduce distress in parents at end-of-life. Findings from the proposed research will provide essential information to promote communication practice standards that can be rapidly translated into practice to improve outcomes for children at end of life, and their parents.

PI_NAMEs: FERGUSON, VERNA L.;MOODY, KAREN ;PERKINS, SUSAN M. (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: Address;Admission activity;Adult;Age;Appointment;arm;attentional control;Cancer Prognosis;Caregivers;Caring;Cessation of life;Child;Clinical;clinical practice;Cluster randomized trial;Communication;Data;Diagnosis;Distress;effective intervention;efficacy evaluation;Emotional;emotional distress;Empathy;end of life;end of life care;Enrollment;Evaluation;Evidence based intervention;experience;Fostering;Goals;Healthcare;Home;Hospice Care;hospice environment;hospice utilization;improved;improved outcome;innovation;Intervention;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediator;Medical;novel;Nurses;Oncology;Outcome;Pain;pain reduction;Palliative Care;Parents;Patient Preferences;Pediatric Oncology;Physicians;Pilot Projects;pilot test;Positioning Attribute;Prognosis;prospective;Provider;Quality of life;randomized, clinical trials;Randomized, Controlled Trials;Readiness;Research;response;satisfaction;Self Assessment;Series;Site;skills;Testing;Therapeutic;Training;Translating;treatment response;Trust;Uncertainty;Visual Aid

PROJECT_TITLE: Evaluation of the Communication Plan Early through End-of-Life (COMPLETE) Intervention

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


ADMINISTERING_IC: AI

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: In support of the NIAID Biodefense Research Program’s aim to develop medical countermeasures for biodefense pathogens, the NIH has funded the construction of 12 Regional Biocontainment Laboratories (RBLs) to support Biosafety Level 2 and 3 (BSL-2 and BSL-3) research. The Tulane National Primate Research Center (TNPRC) is the only National Primate Research Center with an RBL at BSL-3 for the study of high-consequence pathogens, including select agents and toxins. The proposed UC7 will provide support for everyday operation of the TNPRC RBL BSL-3 facility to facilitate research and medical countermeasure development for biodefense, emerging infectious diseases, and pandemic preparedness and response.

PI_NAMEs: RAPPAPORT, JAY  (contact)

PROGRAM_OFFICER_NAME: DIAZ SAN SEGUNDO, FAYNA C

PROJECT_TERMS: animal colony;base;biocontainment facility;biodefense;biosafety level 3 facility;Communicable Diseases;COVID-19;COVID-19 pandemic;Dedications;Development;Emerging Communicable Diseases;emerging pathogen;Ensure;Equipment;Fortification;Funding;germ free condition;Goals;Grant;Health;Human;improved;in vivo;Infrastructure;Laboratories;Maintenance;medical countermeasure;Methodology;National Institute of Allergy and Infectious Disease;nonhuman primate;operation;Operative Surgical Procedures;pandemic preparedness;pandemic response;pathogen;Primates;Procedures;Process;programs;Public Health;Quality Control;Research;Research Infrastructure;Resource Development;response;Safety;safety practice;Structure;success;Toxin;Training;United States National Institutes of Health;Universities;Work;Workforce Development

PROJECT_TITLE: Resources and Workforce Development for the Tulane Regional Biocontainment Laboratory


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: Animals;Area;biocontainment facility;biodefense;Collaborations;Communicable Diseases;Complex;Containment;containment equipment;Data;Decontamination;Engineering;Ensure;Environment;Equipment;Funding;Future;Goals;good laboratory practice;high risk;Laboratories;Maintenance;Measures;Modeling;Occupational Health;operation;Operations Research;pandemic response;pathogen;Primates;Procedures;professional atmosphere;programs;Public Health;quality assurance;Quality Control;Reproducibility;Research;Research Activity;Research Infrastructure;Research Personnel;Research Support;Resource Development;response;Risk;Role;Scientist;Security;Services;Standardization;Structure;System;Toxin;Waste Management;Workforce Development

PROJECT_TITLE: Facility Management Maintenance Operations Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Prevention

PROJECT_TERMS: biocontainment facility;biodefense;Biological Products;biosecurity;Certification;Communities;Containment;design;Diagnostic;Emerging Communicable Diseases;Ensure;Equipment and supply inventories;experience;Funding;Goals;Health;Health protection;Individual;Infectious Agent;Knowledge;Laboratories;Learning;Measures;Monitor;National Institute of Allergy and Infectious Disease;pandemic preparedness;pathogen;Primates;Procedures;Process;Productivity;professional atmosphere;programs;Public Health;Qualifying;quality assurance;Regulation;Research;Research Personnel;Research Support;Resource Development;response;Risk;Safety;Scientist;Secure;Security;Severe Acute Respiratory Syndrome;Staff Development;System;therapy development;Toxin;Training;training opportunity;United States National Institutes of Health;Vaccines;virtual platform;Work;Workforce Development

PROJECT_TITLE: BSL3 Practices Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE LIN28B is a pleiotropic RNA-binding oncofetal protein that correlates with poor prognosis in hepatocellular  carcinoma (HCC). This proposal seeks to understand how LIN28B contributes directly to the metastatic  phenotype of HCC cells and how it contributes to the angiogenic and endothelial modulatory phenotype of HCC  cells using a combination of cell, animal, and human specimen studies. I anticipate that these results will provide  rationale and targets for novel drug and biomarker development for HCC.

PI_NAMEs: FRANSES, JOSEPH WANG (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Advisory Committees;Affect;Agar;Angiogenic Factor;Animal Experiments;Animal Model;Animals;Automobile Driving;Behavior;Biological Assay;Biological Markers;Biological Models;Biology;biomarker development;Blood Vessels;cancer cell;Cancer Center;cancer genomics;career;career development;Cell Communication;Cell Density;Cell Line;Cell model;Cells;Chicago;Clinical;Clinical Data;clinical practice;Coculture Techniques;Collaborations;Communities;Computational Biology;Computer Analysis;Consensus;Data Set;Dedications;Development;Development Plans;Dissociation;DNA Sequence Alteration;drug development;Drug Targeting;Educational process of instructing;Endothelial Cells;Endothelium;Environment;experience;experimental study;fitness;gain of function;Genes;Genomics;Goals;Hep3B;Hepatic;Heterogeneity;Human;implantation;improved;In Vitro;in vitro Assay;in vivo Model;International;Invaded;Investigation;Knock-out;Link;Maintenance;Malignant Epithelial Cell;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;Mentorship;Metastatic Carcinoma;migration;Modeling;Molecular;Molecular Biology;Morbidity - disease rate;mortality;mortality risk;nano-string;Neoplasm Circulating Cells;Neoplasm Metastasis;new therapeutic target;novel;oncofetal antigen;Oncologist;Outcome;overexpression;paracrine;Pathway interactions;Patient Care;Patients;PECAM1 gene;pharmacologic;Phenotype;Physicians;pluripotency;preimplantation;Primary carcinoma of the liver cells;Primary Neoplasm;Prognosis;Proliferating;recruit;Recurrence;Regulatory Pathway;Research;Research Personnel;RNA Binding;RNA immunoprecipitation sequencing;RNA-Binding Proteins;Role;Scientist;Series;single-cell RNA sequencing;Solid Neoplasm;spatial relationship;Specimen;spheroids;Stains;Tail;Technology;Time;Tissue Stains;Tissues;tool;Training;transcriptome sequencing;transcriptomics;Translational Research;Tube;tumor;tumor microenvironment;Tumor Tissue;Universities;Veins;Work

PROJECT_TITLE: Defining pro-metastatic and endothelial-regulatory roles for LIN28B in hepatocellular carcinoma

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: HANOVER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE The cell cortex is the outermost layer of the cell, and it is remodeled to support changes in cell shape, including pinching the cell in two during the final stage of cell division; failure to complete this process is correlated with disease states like cancer. Before these shape changes occur, the cortex is dynamically patterned into waves of signaling and structural proteins. The work proposed here will investigate how and why these patterns form and define the role of cortical patterning in supporting successful cell division.

PI_NAMEs: LANDINO, JENNIFER ELAINE (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Actomyosin;Aneuploidy;Architecture;Award;Biochemical;Biochemical Feedback;cancer cell;career;cell cortex;Cell Cycle;Cell division;Cell membrane;Cell model;cell motility;Cell Physiology;Cell Shape;Cell surface;Cell-Free System;Cells;Chromosomes;Complex;Cytokinesis;Cytoskeletal Modeling;Cytoskeleton;Data;Development;Disease;egg;Electron Microscopy;Embryo;Ensure;Environment;Equity;F-Actin;Faculty;Failure;Feedback;flexibility;fluidity;Goals;Guanosine Triphosphate Phosphohydrolases;in vivo;Individual;Knowledge;Laboratory Research;Lipid Bilayers;Lipids;Liquid substance;Malignant Neoplasms;Mediating;Membrane;Membrane Fluidity;Michigan;Microtubules;migration;Modeling;Molecular;Monomeric GTP-Binding Proteins;novel;Pattern;Pattern Formation;polymerization;Polymers;Positioning Attribute;Preparation;Process;programs;Proteins;Publishing;reconstitution;Regulation;Regulation of Cell Shape;Research;rho;Role;self organization;Shapes;Signal Transduction;Signaling Molecule;Signaling Protein;spatiotemporal;Structural Protein;Structure;success;Surface;System;Testing;Training;Training Support;two-dimensional;Universities;Work;Workplace;Xenopus

PROJECT_TITLE: Investigating the mechanism of self-organized cortical patterning in an artificial cortex

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: PHYSICS

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative We will increase the speed of single-beam SEM systems for connectomics by 10-100 fold without substan- tially increasing cost. We will build computationally efﬁcient methods for aligning and segmenting connectome datasets in a cloud-based infrastructure (BossDB). We will validate the faster pipeline for connectomics and create tools for collaborative connectomics where many individual groups are able to complete portions of larger mammalian brains.

PI_NAMEs: LICHTMAN, JEFF W;PFISTER, HANSPETER ;SAMUEL, ARAVINTHAN D. (contact);SHAVIT, NIR ;WESTER, BROCK A.

PROGRAM_OFFICER_NAME: TALLEY, EDMUND M

PROJECT_TERMS: Acceleration;Affect;Algorithms;Architecture;Artificial Intelligence;Behavior;Brain;broadening participation research;cloud based;Communities;comparative;Computer Hardware;computer infrastructure;Computer software;computerized data processing;connectome data;cost;cost effective;Data;data analysis pipeline;Data Collection;data ecosystem;data ingestion;Data Set;data visualization;Databases;design;Detection;Devices;Electron Microscope;Endowment;Engineering;Failure;Generations;Human;Image;image processing;imaging Segmentation;imaging system;improved;Individual;Infrastructure;intelligent algorithm;Machine Learning;Maps;Methods;Mus;nanoscale;neural;neural circuit;Neurons;Neurosciences;Noise;nonhuman primate;Performance;Process;programs;reconstruction;Research;Research Institute;Research Personnel;Resolution;Resources;Retina;Running;Sampling;scale up;Scanning;Services;Signal Transduction;Slice;Speed;Structure;Synapses;System;Time;tool;Validation

PROJECT_TITLE: BRAIN CONNECTS: Rapid and Cost‐effective Connectomics with Intelligent Image Acquisition, Reconstruction, and Querying


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Alzheimer’s Disease and Related Dementias (ADRD) are global crises that require translational research solutions. A dearth of qualified investigators is available for the sustained effort that will likely be required to fully address this challenge. The Training in Translational ADRD Neuroscience, or TITAN, program will provide novel and necessary training to prepare investigators to lead the nation in research to reduce the impact of these deadly diseases.

PI_NAMEs: GRILL, JOSHUA  (contact);HEAD, ELIZABETH

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Alzheimer's disease related dementia;Neurosciences;Training

PROJECT_TITLE: Training in Translational ADRD Neuroscience (TITAN)

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: EAST LANSING

ORG_DEPT: CHEMISTRY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE The glycyl radical enzyme (GRE) superfamily catalyzes an array of challenging reactions using radical intermediates, including selective hydroalkylation of the alkene fumarate. Despite important applications for human health and environmental concerns, there remain large gaps in our knowledge of this superfamily, particularly within the X-succinate synthase (XSS) class. The aims proposed herein will use advanced cryo- electron microscopy techniques to probes both novel conformations and structures of GREs, as well as develop routes for in vitro cofactor installation and engineering of XSSs to provide synthetically useful C–C bond-forming catalysts.

PI_NAMEs: ANDORFER, MARY CATHERINE (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Investigation and application of hydrocarbon-degrading enzymes using cryo-electron microscopy and directed evolution


NIH_SPENDING_CATS: Bioengineering;Regenerative Medicine

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Tissue damage due to injury, disease, or congenital defect continues to be a critical clinical obstacle in human health and regenerative medicine-based therapies, while a promising strategy, still face two critical obstacles: chronic inflammation and fibrosis. We pose an innovative hypothesis whereby immuno-stromal signaling axes and fibroblast heterogeneity link together inflammation and disrupted mechanotransduction, bridging a critical gap in our understanding of tissue fibrosis and regeneration. Developing a better understanding of immuno- stromal crosstalk will help elucidate disease pathogenesis, new candidates for biomarkers, and targets for therapeutic interventions.

PI_NAMEs: ABEBAYEHU, DANIEL  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Advisory Committees;Atomic Force Microscopy;Biocompatible Materials;biomarker identification;candidate marker;career;cell behavior;Cells;Characteristics;Chemistry;Chronic;Cicatrix;Clinical;clinically relevant;Collagen;Congenital Abnormality;cytokine;Data;Data Set;Development;Disease;Encapsulated;Environment;experimental study;Extracellular Matrix;Face;Fibroblasts;Fibrosis;Focal Adhesions;Foreign-Body Giant Cells;Genes;Goals;Guide RNA;Health;Heterogeneity;Human;Hydrogels;Immune;immune cell infiltrate;Immune response;immunoregulation;Implant;Inflammation;Inflammatory;Injectable;Injury;innovation;Integrins;Interleukin-1;Interleukin-1 beta;knock-down;Knockout Mice;Link;Measures;mechanotransduction;Mediating;Mediator;Mentors;Mentorship;Modeling;Molecular Profiling;Mus;Natural regeneration;novel;Optics;Outcome;p65;particle;Pathogenesis;Pathway interactions;Phase;Phenotype;Phosphorylation;Plastic Surgical Procedures;Platelet-Derived Growth Factor alpha Receptor;Porosity;Preparation;Production;programs;recruit;regeneration potential;regenerative;Regenerative Medicine;Regenerative response;Research;Research Personnel;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Sorting;Specificity;Stromal Cells;subcutaneous;success;targeted treatment;Testing;Therapeutic Intervention;tissue regeneration;tissue repair;Tissues;TNF gene;Training;Work

PROJECT_TITLE: Immuno-stromal axes regulate fibroblast heterogeneity in tissue fibrosis and regeneration


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: CHESTNUT HILL

ORG_DEPT: BIOLOGY

ORG_NAME: BOSTON COLLEGE

PHR: Project Narrative  The main goal of this project is to identify new regulators of cardiac inflammation and fibrosis, two patho- logical features that characterize several cardiac diseases. The fundamental discoveries derived from this re- search are relevant to public health because they will inform the design of strategies to revert and mitigate cardiac fibrosis, for which there are currently no available therapies in the clinical setting.

PI_NAMEs: GONZALEZ-ROSA, JUAN MANUEL (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Acute;Adult;Adverse effects;Affect;Alleles;Animals;Attenuated;Cardiac;Cardiac Myocytes;cardiac regeneration;chemokine;Cicatrix;Clinical;Collection;comparison control;Competence;coronary fibrosis;cost;Deposition;design;Development;Disease;Disease Progression;effective therapy;Exhibits;experimental study;Extracellular Matrix;Feedback;Fibrosis;functional decline;gain of function;Gene Expression Profiling;Gene Modified;Generations;Genes;Genetic Models;genetic variant;Goals;Heart;Heart Diseases;Heart failure;Heart Injuries;Hypertrophy;Immune;Immunocompromised Host;Impairment;Individual;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Injury;inter-alpha-inhibitor;Ischemia;Knowledge;Laboratories;Link;loss of function;Lymphocytic Infiltrate;Macrophage;Mediator;Modeling;Molecular;mortality;Mus;mutant;Mutation;Myocarditis;Natural regeneration;new therapeutic target;NF-kappa B;Outcome;overexpression;Pathologic;Pathology;Persons;Phase;Phenotype;Phosphotransferases;Play;Population;Positioning Attribute;prevent;Process;Production;Progressive Disease;Proliferating;Public Health;recruit;Reperfusion Injury;Reporting;Research;Resistance;response;Role;Serine Proteinase Inhibitors;Siblings;Signal Transduction;Skin;Syndrome;System;T cell infiltration;T-Lymphocyte;Testing;Therapeutic;Tissues;tool;trait;transcriptomic profiling;Transgenic Organisms;Translating;Trypsin Inhibitors;Zebrafish

PROJECT_TITLE: Identifying new regulators of cardiac fibrosis and inflammation using zebrafish

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Telehealth

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Despite the clear need for evidence-based, developmentally targeted, scalable, psychosocial interventions for Adolescents and Young Adult (AYA) survivors of cancer, few exist. Our proposed project builds on a successful resilience intervention designed by AYAs for AYAs, and endeavors to identify the optimal balance of smart-phone versus telehealth intervention delivery, sustainable practice of skills, and creative digital strategies for recognizing AYAs with new or escalating distress. If successful, results will inform future research and clinical strategies for integrating psychosocial and mobile health technologies aimed at improving outcomes for AYAs with cancer during both their initial treatment and their later survivorship.

PI_NAMEs: ROSENBERG, ABBY R (contact);YI-FRAZIER, JOYCE P

PROGRAM_OFFICER_NAME: GUIDA, JENNIFER LYN

PROJECT_TERMS: Accelerometer;active method;Address;Adolescent;Adolescent and Young Adult;Adolescent and young adult cancer patients;Alaska;Anxiety;anxiety symptoms;arm;Award;Cancer Burden;Cancer Survivor;Cancer Survivorship;cancer therapy;Caring;Cellular Phone;Certification;Clinical;Complement;cost;Creativeness;Data;Data Correlations;design;Deterioration;Development;digital;digital applications;digital data;digital media;digital phenotyping;Distress;Education;efficacy evaluation;Equilibrium;evidence base;Evidence based program;Feeling;Goals;Gold;Guidelines;Hawaii;Health Technology;high risk;Human Resources;improved;improved outcome;innovation;instrument;Intervention;intervention delivery;Maintenance;Malignant Neoplasms;medical specialties;Mental Depression;Methods;mHealth;Midwestern United States;mobile application;novel;Outcome;Patient Outcomes Assessments;Patients;Persons;Phase;phenotypic data;pilot test;Population;programs;promote resilience;psychological distress;psychosocial;Psychosocial Assessment and Care;psychosocial outcome;Quality of life;Randomized;randomized trial;Reporting;Reproducibility;resilience;Resources;response;Role;screening;secondary analysis;Self-Examination;Sequential Multiple Assignment Randomized Trial;Signal Transduction;skills;smartphone application;social;Spanish;Stress;stress management;survivorship;telehealth;Telephone;Text;Text Messaging;therapy design;Time;Time Perception;tool;Training;treatment as usual;trial design;video coaching;Vocation;young adult

PROJECT_TITLE: Promoting Resilience in Early Survivorship among Adolescents and Young Adults with Cancer

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: IOWA CITY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The public health impact of physical activity during the critical midlife period to slow cognitive aging depends on new insights about how to increase both the effectiveness and sustainability of physical activity intervention programs designed with the heart and brain in mind. Moderate-to-vigorous intensity activity is critical for these benefits, but can be difficult to achieve due to high demands on self-regulatory abilities needed to reverse sedentary habits and mange negative feelings evoked by exercise. The proposed research will develop and test the efficacy of cognitive training strategies designed to improve these self-regulatory capacities for middle-aged adults to adopt and sustain a physically active lifestyle.

PI_NAMEs: VOSS, MICHELLE WEBB (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Accounting;active lifestyle;Adherence;Adopted;Adoption;Adult;Affect;Affective;Age;Age-associated memory impairment;Aging;aging brain;Alzheimer's disease risk;American;Attention;Behavior;behavior change;Benchmarking;Boston;Brain;brain health;Cities;Cognitive;Cognitive aging;cognitive capacity;cognitive control;cognitive training;computerized;Control Groups;control theory;cost;Coupled;critical period;dementia risk;design;Development;E-learning;Effectiveness;Effectiveness of Interventions;efficacy testing;Emotional;Environment;environmental change;ethnic diversity;Exercise;exercise intervention;experience;Experimental Designs;Exposure to;Face;Feedback;Feeling;flexibility;Fright;Future;Geography;Goals;Habits;Health;Heart;Impaired cognition;improved;Informal Social Control;insight;Intention;Intervention;intervention program;Iowa;Life;Literature;Longevity;Maintenance;mange;Methods;middle age;Mind;Modeling;Motivation;negative affect;Nerve Degeneration;Pathology;Performance;Persons;Phase;Physical activity;physical conditioning;Physical Exercise;Population;programs;promote resilience;psychologic;psychosocial;Public Health;racial diversity;Randomized, Controlled Trials;Reporting;Research;Research Support;resilience in aging;Risk Reduction;Risk Taking;Role;Rural;Sampling;Science;sedentary;Self Efficacy;Short-Term Memory;Site;stability testing;Stimulus;Structure;success;Testing;theories;Training;Training Programs;Treatment Efficacy;vigorous intensity;young adult

PROJECT_TITLE: Targeting Cognitive Control to Improve Physical Activity Adherence in Midlife for Alzheimer's Risk Reduction


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Substance Misuse

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: There is mounting evidence for the key role of social and structural determinants of health in understanding HIV prevention and care outcomes. Successful implementation and sustainment of sociostructural interventions will need to systematically consider disparity determinants, adaptations, and other ways to ensure the outcomes of sociostructural interventions are reached and health equity is achieved. The goal of this proposal is to develop the Sociostructural Implementation Science Coordination Initiative to support the companion R01s with D&I science to coordinate data harmonization and foster opportunities for cross-site learning, as well as build the capacity of the larger research and practice fields.

PI_NAMEs: BENBOW, NANETTE DIOR;MUSTANSKI, BRIAN  (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Achievement;Address;Administrative Supplement;Affect;AIDS prevention;Behavioral;care outcomes;career;Caring;Collaborations;Collection;Common Data Element;Communication;Companions;Consultations;cost;Cost Analysis;dashboard;Data;data harmonization;Development;Disparity;Dissemination and Implementation;dissemination science;Effectiveness;effectiveness outcome;Ensure;Epidemic;Equity;evidence base;Evidence based intervention;experience;Fostering;Funding;Goals;Health;health equity;health inequalities;Hearing;HIV;HIV disparities;implementation cost;implementation determinants;implementation measures;implementation outcomes;implementation research;implementation science;implementation strategy;implementation/effectiveness;improved;Individual;Inequity;Infrastructure;Institution;Intervention;investigator training;Joints;Journals;Knowledge;Leadership;Learning;Logic;Measurement;Measures;meetings;Methodology;Methods;Modeling;Needs Assessment;Newsletter;Outcome;Persons;Policies;pre-exposure prophylaxis;prevent;Procedures;public database;public health research;Research;Research Personnel;Research Priority;Research Project Grants;Resources;Risk;scale up;Science;service delivery;Services;shared decision making;Site;social determinants;social health determinants;social structure;structural health determinants;Structure;symposium;System;systematic review;Taxonomy;Testing;tool;Training;transmission process;United States National Institutes of Health;Viral;virtual;Walking;web site

PROJECT_TITLE: The Sociostructural Implementation Science Coordination Initiative

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-W(50)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Social interactions with mature social partners are critical for an infant’s health and successful development as they scaffold and support far-reaching outcomes including vocabulary development, school achievement, self- control, and executive functioning. The proposed research connects one behavior of mature social partners, vocalizations, with infant autonomic activity and sustained attention, a cognitive achievement highly predictive of individual differences in infant visual attention, self-control, language, and later school achievement. The proposed research will advance the field by linking the role of in-the-moment measures of caregiver vocalization, to infant gaze and infant autonomic activity to long-term developmental outcomes such as self-regulated attention and learning, providing a potential new path to determining targets for intervention for at-risk infants.

PI_NAMEs: BORJON, JEREMY ISAAC (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TITLE: How infant-directed speech organizes the attentional state of infants


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Lung;Pediatric;Pediatric Cancer;Rare Diseases;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE According to the American Cancer Society it is estimated that 800-900 new osteosarcoma cases will be diagnosed in 2020. The majority of cases are in people aged 30 or under and 5-year survival rates are approximately 70%; however, with lung metastasis this number drops to a mere 20%. In this project, we will utilize high-resolution imaging techniques and comparative models to determine the effects of the microenvironment on metastatic osteosarcoma drug response with the goal to develop novel approaches that increase the sensitivity of these cells to existing therapies and improve survival.

PI_NAMEs: DAVIES, ALEXANDER E (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: ABCB1 gene;ABCC1 gene;ABCG2 gene;Address;aged;AKT Signaling Pathway;American Cancer Society;Antineoplastic Agents;BCL2 gene;behavior influence;bone;Brain;Breast Cancer Cell;cancer cell;career;Cause of Death;Cell Fraction;Cell Physiology;Cell Proliferation;Cells;Childhood Osteosarcoma;Cisplatin;Collaborations;comparative;Cues;cytotoxic;Data;Development;Diagnosis;Disease;Doxorubicin;Drops;Drug Modulation;Drug resistance;drug sensitivity;Drug Targeting;Drug usage;drug-sensitive;Exhibits;extracellular;Extracellular Signal Regulated Kinases;FOS gene;Gene Expression;Genes;Goals;Heterogeneity;high resolution imaging;Imaging Techniques;Immediate-Early Genes;improved;Individual;Invaded;Lesion;Ligands;Link;live cell imaging;Liver;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;MCL1 gene;Mediating;Mentors;Metastatic Neoplasm to the Lung;Metastatic Osteosarcoma;Modeling;mortality;Multidrug Resistance Gene;Neoplasm Metastasis;neoplastic cell;non-genetic;novel strategies;Osteosarcoma;Outcome;paracrine;Paracrine Communication;Pathway interactions;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiologic pulse;Postdoctoral Fellow;Primary Neoplasm;Process;programs;Proto-Oncogene Proteins c-akt;Receptor Protein-Tyrosine Kinases;Research;Resistance;response;Sampling;screening;Signal Induction;Signal Pathway;Signal Transduction;Site;skills;Solid Neoplasm;Survival Rate;targeted treatment;Techniques;Testing;Time;transcriptome sequencing;Transforming Growth Factors;Translating;Treatment Efficacy;treatment response;tumor;Tumor Biology;tumor microenvironment;Up-Regulation;Work

PROJECT_TITLE: Targeting ERK-AKT-mediated single-cell drug response heterogeneity in metastatic osteosarcoma


ORG_CITY: HERSHEY

ORG_DEPT: NEUROLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE Reduction of risk for Alzheimer’s disease and related dementias (ADRD) may be possible through lifestyle change including increased physical activity. While novel and effective behavioral interventions targeting increased physical activity and positive cognitive outcomes have been developed over the past several decades, little is known about the mechanisms that lead to longer-term adherence to health-promoting levels of physical activity behavior (long-term “maintenance”). The proposed adherence-promoting mHealth intervention is designed to support the development of a psychological scaffold for long-term physical activity maintenance in midlife that will help promote cognitive health into older age.

PI_NAMEs: HAKUN, JONATHAN G. (contact)

PROJECT_TERMS: Adherence;Adult;adult obesity;Age Years;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;arm;Attention;Behavior;behavior change;Behavior Therapy;blind;Body mass index;brain health;care costs;Cause of Death;Cellular Phone;Certification;Cognition;Cognitive;cognitive ability;cognitive change;cognitive performance;cognitive testing;combat;comparison group;cost;Custom;Data;Dementia;dementia risk;design;Development;distraction;Ecological momentary assessment;efficacy testing;Emotions;executive function;exercise intervention;exercise physiologist;Face;Family;fitbit;follow-up;Frequencies;Goals;Health;Health education;Health Promotion;Healthcare;healthspan;Hour;human old age (65+);improved;Independent Living;Individual;Informal Social Control;innovation;instrumentation;Intervention;intervention effect;life span;Life Style;lifestyle intervention;light intensity;Maintenance;Measurement;Measures;meetings;Metabolic;Methods;mHealth;mhealth interventions;middle age;Modeling;Monitor;novel;older adult;Outcome;Participant;Performance;Persons;Phase;Physical activity;physical conditioning;prevent;primary endpoint;Primary Prevention;programs;psychologic;Psychosocial Factor;Publishing;Quality of life;randomized trial;recruit;Research;Resources;Risk;Running;scaffold;sedentary;Self Efficacy;Surveys;Technology;Testing;Thinking;Translating;treatment arm;United States National Institutes of Health;Variant;wearable sensor technology;Weight;Work;Wrist

PROJECT_TITLE: Mechanisms of Adherence to Light Intensity Physical Activity to Prevent Alzheimer's Disease and Related Dementias


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: Project Narrative This D43 is a multidisciplinary, international, and inter-African continental HIV research training program: NexT generation traininG in HIV Research: Immunity in the First 1000 days in mother-infant dyadS” (TIGRIS). We will institute a laboratory-based training program to investigate how HIV infection in the pregnant woman leads to adverse birth outcomes and neonatal immune dysfunction and complement this with didactic two- semester course in HIV and reproductive immunology that will enhance HIV scientific capacity in Africa.

PI_NAMEs: CHAKRABORTY, RANA ;GRAY, CLIVE MAURICE (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: adverse birth outcomes;Africa;African;Basic Science;Bilateral;Canada;Child;Childhood;Clinic;Clinical;Clinical Sciences;Data;Data Analyses;Doctor of Philosophy;Faculty;Funding;graduate student;Grant;HIV;HIV Infections;Immune System Diseases;Immunity;Immunology;Infant;innovation;International;Investigation;Kenya;Knowledge;Laboratories;laboratory experience;low and middle-income countries;Malawi;Medical center;medical schools;meetings;Mentorship;Morehouse School of Medicine;Mothers;multidisciplinary;Neonatal;next generation;novel;Pediatric Hospitals;Postdoctoral Fellow;Pregnancy;Pregnant Women;programs;reproductive;Reproductive Immunology;Research;Research Institute;Research Personnel;research study;Scientist;Shapes;South Africa;Southern Africa;Structure;Technology;Training;Training Programs;Uganda;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Next Generation Training in HIV Research: Immunity in the First 1000 days in mother-infant dyads (TIGRIS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-S (55)]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: State College

ORG_NAME: ATLAS BIOLOGICS, LLC

PHR: Targeted therapies have revolutionized patient care for a wide range of cancers, but are fundamentally limited by acquired resistance mutations. Current technologies used in industry to evaluate the mutational landscapes of next generation targeted therapies are limited in sensitivity, incomplete, and retrospective. This project proposes to develop and commercialize deep mutational scanning with duplex sequencing (DMS-DS), the most comprehensive and accurate platform available for measuring the mutational landscape of investigational targeted therapies.

PI_NAMEs: REYNOLDS, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: REGMI, SAROJ GOPAL

PROJECT_TERMS: Acceleration;Amino Acid Substitution;anti-cancer;Antineoplastic Agents;Architecture;base;bcr-abl Fusion Proteins;Bioinformatics;Businesses;Cancer Patient;cancer therapy;cancer type;Cause of Death;Cell Line;Cells;Client;Clinical;clinical candidate;clinical development;Clinical Trials;clinically relevant;Collaborations;commercialization;Complex;Data Reporting;design;Detection;Development;Dose;Drug Design;drug development;Drug Evaluation;Drug resistance;Drug Screening;Drug Targeting;effective therapy;Evolution;experience;Frequencies;Funding;Goals;Grant;Imatinib;improved;In Vitro;in vitro Assay;Industry;inhibitor;Innovation Corps;interest;kinase inhibitor;Knowledge;lead candidate;Libraries;machine learning model;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Marketing;Measurement;Measures;Methods;Molecular Biology;mortality;multidisciplinary;Mutagenesis;mutant;Mutation;mutation screening;next generation;next generation sequencing;novel therapeutics;Oncology;Outcome;Patient Care;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phosphotransferases;Pilot Projects;Positioning Attribute;pre-clinical;Precision therapeutics;prevent;Process;Prognosis;programs;Proteins;relapse patients;Reporting;Reproducibility;Research;Research Personnel;Resistance;resistance mutation;response;rho;Scanning;screening;Secure;sequencing platform;Service delivery model;Services;Specificity;success;symposium;targeted agent;targeted treatment;Techniques;Technology;tool;Translating;treatment planning;Validation

PROJECT_TITLE: Development of Deep Mutational Scanning with Duplex Sequencing (DMS-DS) for anti-cancer drug evaluation and administration

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-Q (J2)]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES

PHR: Narrative Oral diseases affect approximately 3.5 billion people globally, increasing health and economic burdens while significantly decreasing quality of life. This is especially true in sub-Saharan Africa where this burden is made worse by HIV. In this application, whose overall objective is to strengthen the oral health research capacity in Uganda, the team will work through the proposed aims to plan for the establishment of an oral health research training program for Makerere University and Uganda Christian University, that is well aligned to the NIH HIV AIDS priority area on research training of the multidisciplinary workforce required to conduct High Priority HIV/AIDS or HIV/AIDS-related research.

PI_NAMEs: BUWEMBO, WILLIAM  (contact);SEMITALA, FRED C

PROJECT_TERMS: Address;Adult;Affect;Africa South of the Sahara;Aging;antiretroviral therapy;Applications Grants;Area;burden of illness;Communicable Diseases;comorbidity;Disease;Economic Burden;experience;follow-up;global health;Goals;Grant;Health;Health Personnel;Health Services Accessibility;HIV;HIV/AIDS;Human Resources;Inequality;low and middle-income countries;Morbidity - disease rate;mortality;Mouth Diseases;multidisciplinary;neglect;Oral cavity;Oral health;oral HIV;Patients;Persons;Play;Population;Poverty;Professional Education;Public Health;Quality of life;Research;Research Training;Resources;Role;Scientist;Training;Training Programs;Uganda;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Strengthening HIV Oral Health Human Resource for Research Capacity in Uganda.


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Gene Therapy;Genetics;Human Genome;Organ Transplantation;Regenerative Medicine;Transplantation

ORG_CITY: NEW YORK

ORG_NAME: ENYX THERAPEUTICS, LLC

ORG_STATE: NY

PHR: Narrative. Human autologous fat transplantation, widely used for soft tissue reconstruction, is seriously hampered by loss of the grafted fat because of a lack of vascular supply to support delivery of oxygen and nutrients to the transplanted fat. We propose to solve this challenge by genetically modifying harvested fat prior to transplantation with an adenovirus gene transfer vector coding for all 3 major isoforms of vascular endothelial growth factor, a potent mediator of angiogenesis. We will assess this strategy in studies quantifying the survival of human fat transplanted to immunodeficient mice.

PI_NAMEs: CRYSTAL, RONALD G (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Acceleration;Address;Adenovirus Vector;Adenoviruses;Adipocytes;angiogenesis;Animal Experiments;Autologous;Biological Availability;Biotechnology;Blood Vessels;Capsid;Cicatrix;Clinical;Code;Collaborations;comparison control;Contracture;Data;Defect;Development;Disease;Dose;effectiveness trial;Esthetics;Experimental Models;fat grafting;Fatty acid glycerol esters;Funding;Gene Modified;gene therapy;gene transfer vector;Genetic Medicine;Genomics;Harvest;Hour;Human;Hybrids;Immunity;Immunocompetent;Immunodeficient Mouse;improved;in vivo;Individual;Infrastructure;Investigational Drugs;Ischemia;Laboratories;Length;Maintenance;Mediating;Mediator;Medical;Mus;neovascularization;novel;Nutrient;Operative Surgical Procedures;Oxygen;Phase;Phase I Clinical Trials;Population;pre-clinical;pre-Investigational New Drug meeting;Protein Isoforms;Protocols documentation;Radiation induced damage;reconstruction;Reconstructive Surgical Procedures;response;Scleroderma;Serotyping;Skin graft;Small Business Technology Transfer Research;soft tissue;Stimulus;subcutaneous;success;Suggestion;Surgical Oncology;Technology;Testing;Therapeutic;Time;tissue reconstruction;Tissues;Toxicology;Translating;Transplantation;Trauma;traumatic wound;Vascular blood supply;Vascular Endothelial Growth Factors;Vascularization;vector;VEGF121 gene;VEGFA gene

PROJECT_TITLE: Gene Therapy-mediated Angiogenesis to Enhance Survival of Transplanted Fat

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (11)]


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: STONY BROOK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Powassan virus (POWV) is a tick-borne virus that causes a 10% fatal brain disease, and a new tick POWV isolate, LI9, was found to cause highly lethal brain damage in aged mice, a finding that mimics POWV disease in elderly patients. In contrast, an attenuated POWV, LI9-P, fails to cause brain damage in mice and is a potential vaccine that differs in its ability to regulate antiviral responses of cells that form brain barriers. Paired lethal and attenuated POWVs, and our unique ability to modify POWVs, permit us to propose defining determinants of POWV disease, mechanisms of POWV entry into the brain, neuroinflammation, age-dependent POWV lethality mechanisms and potential inhibitors of brain damage applicable to the elderly.

PI_NAMEs: MACKOW, ERICH R (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Age;age difference;age related;aged;aging population;Alzheimer's Disease;Anti-viral Response;Antibodies;Attenuated;attenuation;Bite;Black-legged Tick;Blood;Body Weight decreased;Brain;Brain Diseases;brain endothelial cell;Brain Injuries;C57BL/6 Mouse;Cell Aging;Cell Culture Techniques;Cell surface;cell type;Cell-Matrix Junction;Cells;Central Nervous System Diseases;chemokine;Choroid Plexus Epithelium;cytokine;Differentiation Antigens;Disease;Elderly;Encephalitis;Epithelial Cells;Flavivirus;Flow Cytometry;glial activation;Human;Immunohistochemistry;immunopathology;In Vitro;Incidence;Induction of Apoptosis;Infection;Inflammation;Inflammatory;inhibitor;Interferons;Kinetics;Macrophage Activation;Mediating;Microglia;Mitotic;Modeling;mouse model;Mus;mutant;Mutation;Natural regeneration;nerve stem cell;Nervous System Trauma;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neurons;neuropathology;neurovascular;neurovirulence;old mice;older patient;Outcome;Pathology;Patients;Powassan virus;prevent;Productivity;Proteins;Quantitative Reverse Transcriptase PCR;Rationalization;regenerative;Regulation;Repression;response;reverse genetics;Role;senescence;senescent cell;senolytics;single cell sequencing;single-cell RNA sequencing;Site;Survivors;System;T cell response;T-Lymphocyte;Therapeutic;therapeutic evaluation;tick saliva;tick-borne flavivirus;tick-borne virus;Ticks;Tropism;Vaccines;Viral Encephalitis;Viral load measurement;Viral Load result;virtual;Virulent;Virus Diseases

PROJECT_TITLE: CNS Senescence and Immunopathology in Lethal POWV Infection of Aged Mice

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LG-M (M1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: PROJECT NARRATIVE African American and Latino youth are more likely to experience an unmet mental health or psychosocial need than do their white counterparts. School-based and pediatric primary care services are ideal hubs to provide mental health, healthcare, social services, and prevention to students and families who otherwise face barriers to care. Using Participatory Design and Community Partnered Participatory Research (CPPR), the proposed intervention is a model of care for connecting youth ages 11-24 to mental health care and supports by combining mobile technology for screening, triage and care coordination, co-created with the community and used by culturally responsive individuals called family and youth navigators, in school-based and pediatric primary care services.

PI_NAMEs: FORTUNA, LISA R (contact);KATAOKA, SHERYL H

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: Address;African American;Age;Algorithms;Area;Asian;Awareness;barrier to care;Black race;care coordination;care systems;Caregivers;Caring;Child;Child Health;Child health care;Child Mental Health;child services;Childhood;children of color;Clinical;clinical care;Code;Color;Communication;Communities;community based participatory approach;community based participatory research;cost;cost efficient;design;digital;digital health;digital tool;Disadvantaged minority;Disparity;Effectiveness;Ensure;ethnic minority;experience;Face;Family;Health;health determinants;health disparity;health inequalities;Health Services Accessibility;Health system;Healthcare;Immigrant;improved;Individual;Informatics;innovation;innovative technologies;Intervention;Latino;Los Angeles;Measures;member;Mental Health;Mental Health Services;minority children;mobile computing;Modeling;navigation aid;open source;Outcome;peer support;Policies;Poverty;preference;Prevention;Primary Care;primary care services;Process;Provider;Psychiatry;psychosocial;Public Health;racial minority status;Research;resilience;Resources;Risk;San Francisco;school district;Schools;screening;service delivery;social determinants;social health determinants;Social Work;socioeconomic disadvantage;Students;System;Technology;Time;tool;traditional care;Triage;Trust;Visual;Wellness Center;Youth

PROJECT_TITLE: By Youth, For Youth: Digital Supported Peer Navigation for Addressing Child Mental Health Inequities.


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Stroke

ORG_CITY: CHICAGO

PHR: Project Narrative Brain-related problems remain common in persons living with HIV despite improvements in HIV treatment. This project is a continuation of research training to develop scientists at the University of Ibadan, Nigeria to improve the brain health of people living with HIV.

PI_NAMEs: GORELICK, PHILIP B (contact);OMIGBODUN, OLAYINKA OLUSOLA

PROJECT_TERMS: Africa;Area;Articulation;biobehavior;Brain Diseases;career;Cementation;Clinical;Clinical Sciences;Development;Doctor of Philosophy;Educational Curriculum;Enrollment;Epidemiology;Faculty;Funding;gender minority group;Goals;Grant;Health;HIV;implementation science;improved;Infrastructure;innovation;Intervention;Lead;Leadership;Medical;Medicine;member;Mental Health;Mentors;multidisciplinary;National Institute of Child Health and Human Development;neuroAIDS;Neurocognitive;Neurologic;Neurology;Neuropsychology;Nigeria;Outcome;Ownership;Persons;Physicians;Postdoctoral Fellow;programs;Psychiatry;Public Health;Radiology Specialty;Research;Research Personnel;Residual state;Resources;Risk;Sexual and Gender Minorities;sexual minority group;skills;Social Behavior;Social Sciences;Stigmatization;Stroke;stroke intervention;Structure;Time;Training;Training Programs;Translational Research;Trust;Universities

PROJECT_TITLE: Multidisciplinary NeuroAIDS Research and Training Program to Improve HIV Outcomes in Nigeria and Africa


ORG_CITY: JOS

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: JOS UNIVERSITY TEACHING HOSPITAL

PHR: Narrative Antiretroviral therapy programs put into place by PEPFAR, the Global Fund and others have resulted in a remarkable decrease in HIV-related morbidity and mortality; however, the rate of certain cancers are rising significantly as HIV population are aging. Most sub-Saharan African medical institutions are ill prepared to deal with this emerging health challenge. This Nigerian-led research-training program will build capacity in molecular cancer epidemiology, biostatistics, and clinical investigation to train researchers to conduct population-based molecular epidemiology and diagnostics research, leading to the development of preventative and therapeutic strategies to reduce incidence and decrease mortality of HIV-associated malignancies in Nigeria.

PI_NAMEs: ACHENBACH, CHAD J;MUSA, JONAH ;ODUKOYA, OLUWAKEMI ;SILAS, OLUGBENGA AKINDELE (contact)

PROJECT_TERMS: Address;Africa South of the Sahara;African;Aging;AIDS related cancer;antiretroviral therapy;Area;Biological Assay;Biological Markers;Biometry;Cancer Diagnostics;cancer epidemiology;Clinical;Clinical Data;clinical investigation;Clinical Investigator;co-infection;Collaborations;Collection;Country;design;Diagnosis;Diagnostics Research;Distance Learning;Doctor of Philosophy;Educational workshop;Epidemic;Epidemiologist;Epidemiology;epidemiology study;epigenomics;Funding;Goals;Grant;HIV;improved;Incidence;innovation;Institution;Interdisciplinary Study;Laboratories;Leadership;low and middle-income countries;Malignant Neoplasms;Master of Science;Medical;Mentorship;Molecular;Molecular Epidemiology;Molecular Epidemiology of Cancer;Morbidity - disease rate;mortality;Nigeria;Nigerian;novel;Oncogenic;point of care testing;Population;population based;Prevention;Preventive;programs;Protocols documentation;Research;Research Personnel;Research Project Grants;Research Training;Scientist;screening;Therapeutic;Training;Training Programs;Translating;United States National Institutes of Health;Universities;Validation;Viral

PROJECT_TITLE: Northwestern/Nigeria Research Training Program in HIV and Malignancies (NN-HAM)


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project Narrative Incarcerated individuals have higher rates of chronic disease than the general population, including more hypertension, diabetes, high cholesterol, and obesity. The Chronic Disease Self-Management Program (CDSMP) is an evidence-based disease management program that has been utilized in state corrections systems on a limited basis; however, there has been little deliberate research investigation into efficient and effective strategies for scaling up the intervention among older adults within state corrections systems. The research objective of this K01 is to use mixed methods research approaches to engage community-agency CDSMP leaders, correctional staff, and incarcerated individuals in developing strategies to maximize the scalability of the Chronic Disease Self-Management Program among older adults within a state correctional system.

PI_NAMEs: SNEED, RODLESCIA  (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Age;Area;Assessment tool;biopsychosocial;burden of chronic illness;burden of illness;career;Cholesterol;Chronic;Chronic Disease;Communicable Diseases;Communities;community engagement;Complex;correctional system;cost;Data;depressive symptoms;Development;Diabetes Mellitus;Disease;Disease Management;disease model;Educational workshop;Emergency department visit;Ensure;evidence base;Evidence based program;Exercise;experience;Funding;General Population;Gerontology;Goals;Health;health care service;health disparity;Health Expenditures;Healthcare;Hospitalization;Hypertension;implementation research;implementation science;implementation trial;Imprisonment;improved;Individual;Infrastructure;innovation;Intervention;Interview;Investigation;Justice;knowledge base;Link;Manuals;member;Mental disorders;Mentors;Morbidity - disease rate;mortality;neglect;Obesity;older adult;organizational structure;Outcome;pain symptom;Participant;peer;Persons;Persuasive Communication;physical conditioning;Population;primary health service;prison population;Prisons;Privatization;Process;programs;Randomized;randomized trial;Recommendation;recruit;Research;Research Methodology;Research Personnel;Resource-limited setting;Resources;scale up;Security;Self Care;Self Efficacy;Self Management;self-management program;social;Standardization;Substance abuse problem;Surveys;Testing;Time;Training;women versus men

PROJECT_TITLE: Maximizing the Scalability of the Chronic Disease Self-Management Program (CDSMP) Among Older Adults in State Correctional Settings

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Precision Medicine

PHR: PROJECT NARRATIVE The findings from this study will help determine the efficacy of acupuncture on reducing chemotherapy-induced peripheral neuropathy pain when compared to placebo. It will also help evaluate acupuncture's effect on improving sensory nerve recovery and identify neurobiological markers to predict acupuncture's treatment effect. The study findings may contribute to identification of a non-pharmacological method to improve patients' quality of life and help personalize acupuncture treatment.

PI_NAMEs: BAO, TING  (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Acupuncture Therapy;Affect;afferent nerve;American Society of Clinical Oncology;Analgesics;arm;blind;Brief Pain Inventory;Cancer Center;Cancer Patient;Cancer Survivor;care providers;chemotherapy;Chemotherapy-induced peripheral neuropathy;Chinese Traditional Medicine;chronic musculoskeletal pain;Clinical;Clinical Trials Design;Complication;conditioned pain modulation;Data;Disabling;Double-Blind Method;duloxetine;effective therapy;Effectiveness;efficacy evaluation;Electroacupuncture;experience;Fatigue;Fiber;follow-up;functional improvement;Goals;Headache;Hour;Impairment;improved;Intervention;Longterm Follow-up;Measurement;Measures;Methods;minimally invasive;multidisciplinary;Nausea;Neurobiology;neurotoxic;Nonpharmacologic Therapy;novel strategies;Numbness;Numeric Rating Scale;outcome prediction;Pain;Pain Measurement;pain reduction;Pain Threshold;painful neuropathy;Participant;Patient Care;Patient Preferences;Patients;Peripheral Nervous System Diseases;personalized chemotherapy;Pharmaceutical Preparations;pharmacologic;Phase;Pilot Projects;placebo controlled study;Placebos;predicting response;Prediction of Response to Therapy;pressure;primary outcome;Quality of life;Randomized;randomized placebo-controlled clinical trial;Randomized, Controlled Trials;Recommendation;Recovery;Research;Role;Sample Size;Scientist;Sensory;Severities;side effect;Solid Neoplasm;standard of care;Symptoms;Tactile;Techniques;Testing;three-arm trial;treatment as usual;treatment effect;treatment response;Treatment-related toxicity;United States;vibration

PROJECT_TITLE: Acupuncture for Chemothrapy-induced Peripheral Neuropathy Treatment (ACT) Trial

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Palliative Care;Patient Safety

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Defining and monitoring serious and other adverse events in clinical trials involving older adults with serious illness pose challenges to the research community such as the reporting of events that are: implausibly related to the intervention, misaligned with patient values, and/or stemming from well-known relationships between the events and other conditions. In 2020, the NIA sponsored an initiative to convene investigators, regulators, sponsor agency members, and patient stakeholders to address the challenges, resulting in a new framework to support improved reporting. The proposed project will 1) develop the details of the methodology for defining, classifying and reporting (S)AEs in clinical trials involving older, seriously ill adults; 2) create publicly available tools to support the research community; and 3) conduct widespread dissemination and implementation of the framework.

PI_NAMEs: BAIM-LANCE, ABIGAIL ;KITZMAN, DALANE W (contact)

PROGRAM_OFFICER_NAME: MERCURE, KATHLEEN ELIZABETH

PROJECT_TERMS: Address;Adult;Adverse event;American;Behavioral trial;Capsicum;Caring;Cessation of life;Classification;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Communication;Communities;Conduct Clinical Trials;Consensus;Data;decision making algorithm;Disease;Dissemination and Implementation;Education;Etiology;Event;Funding;Goals;Group Meetings;Hospitalization;implementation framework;improved;Institution;Institutional Review Boards;Intervention;Life;medical schools;meetings;member;Methodology;Monitor;multidisciplinary;National Institute on Aging;older adult;Palliative Care;Participant;Patient Representative;Patients;peer;Phase;Population;Probability;Professional Organizations;public health priorities;Reporting;Research;Research Personnel;Research Project Summaries;Research Support;Resources;Safety;Series;Serious Adverse Event;Social Behavior;stem;Structure;tool;Training;uptake;web site;webinar;working group

PROJECT_TITLE: Developing and Disseminating the Approach to Defining, Classifying, and Monitoring Adverse and Serious Adverse Events in Clinical Trials involving Older, Seriously Ill Populations


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE  This proposed training program will leverage the existing HIV research and teaching platforms at University of California, Los Angeles (UCLA) to support HIV capacity building at Hanoi Medical University (HMU) and Chiang Mai University (CMU). Aligning with NIH HIV research priorities, the scientific areas of HIV training will include co-occurring conditions of HIV, HIV service disparities, advanced biomedical strategies for HIV and comorbidity prevention, implementation science and digital health. With highly individualized and targeted training and support, junior to mid-career faculties and researchers at HMU and CMU will establish and assume leadership roles in a multidisciplinary HIV research and training vanguard hub to provide consultation, training, and leadership in state-of-the-art HIV prevention and treatment research throughout Southeast Asia.

PI_NAMEs: ANGKURAWARANON, CHAISIRI ;LE, GIANG M;LEE, SUNG-JAE  (contact);LIN, CHUNQING

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;behavioral health;Binding;biobehavior;Border Crossings;California;career;career development;Career Mobility;Collaborations;comorbidity;Country;driving force;Educational Curriculum;Educational process of instructing;Educational workshop;Ensure;Event;evidence base;Exercise;Faculty;Fellowship Program;forging;Funding;global health;Health;Health Professional;HIV;HIV/AIDS;improved;Infrastructure;Leadership;Los Angeles;Manuscripts;Measurable;Medical;medical schools;Mentors;Mentorship;mid-career faculty;multidisciplinary;next generation;peer coaching;Pharmacologic Substance;population health;Positioning Attribute;prevent;prevention service;programs;Public Health;Research;Research Personnel;Research Project Grants;Research Proposals;Resources;response;Role;skills;Southeastern Asia;Structure;Substance abuse problem;summer institute;symposium;System;Thailand;Time;Training;Training Programs;treatment services;United States National Institutes of Health;Universities;Vietnam;Visit

PROJECT_TITLE: Cutting-edge, Customized, and Comprehensive (CCC) HIV capacity building for Vietnam and Thailand


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Nutrition;Pediatric

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative:  Building on findings from animal studies and on preliminary data, from our laboratory, in adolescents with depression and anxiety, this project will be the first to investigate the impact of iron deficiency on brain iron content, brain structural and functional development, and psychiatric symptom severity. This information is necessary to guide future preventive interventions during a period of rapid brain maturation.

PI_NAMEs: CALARGE, CHADI A. (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: 17 year old;Address;Administrative Supplement;Adolescence;Adolescent;Adult;Affect;Anatomy;Anemia;Animals;Anxiety;anxiety symptoms;Awareness;Basal Ganglia;Blood;Bone Marrow;Brain;brain iron;brain tissue;Cause of Death;Child;child depression;Childhood;Clinical;clinically significant;cofactor;Cognitive deficits;Communities;Coupled;Data;depressive symptoms;design;Development;Diagnosis;Disease;Distress;Enrollment;Enzymes;Erythrocytes;Etiology;Female;Female of child bearing age;Ferritin;Funding;Future;Goals;Growth;Guidelines;Hippocampus;Image;Impairment;improved;Iron;iron deficiency;Laboratories;Life;Magnetic Resonance Imaging;Magnetism;Maps;Measurement;Measures;Medical;Menstruation;Metabolism;Methodology;micronutrient deficiency;Mitochondria;morphometry;Motility;Myelin;myelination;Neurodegenerative Disorders;neuron development;neuropsychiatry;novel;Organ;Oxygen;parent grant;Participant;Performance;Peripheral;Phase;Play;Population;Predisposition;Prevalence;preventive intervention;Production;Productivity;psychiatric symptom;Psychopathology;Reproducibility;Research;Research Personnel;Risk;Role;Sampling;Scanning;Serum;Severities;Signal Transduction;Source;Spatial Distribution;Structure;suicidal risk;Symptoms;Techniques;Therapeutic Intervention;Time;Tissues;tool;trend;Validation;white matter;Work;Youth

PROJECT_TITLE: Iron Deficiency and Brain Development in Youth with Internalizing Disorders - Administrative Supplement

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Finding a permanent cure for people living with HIV is a key priority of the NIH, requiring broad and inclusive basic science research into how the virus remains latent in people on antiretroviral therapy. However, although over 70% of HIV patients live in Africa, very little of the basic science of cure research involves African patients or scientists, a key gap that needs urgent remedy. This D43 training program is a collaboration between two institutions (Washington University in St. Louis and the University of Ghana) to develop a comprehensive basic science research training program to prepare the next generation of Ghanaian researchers to conduct high- quality HIV basic science and cure research.

PI_NAMEs: BONNEY, EVELYN YAYRA;KYEI, GEORGE  (contact);SHAN, LIANG

PROJECT_TERMS: Affect;Africa;African;Basic Science;Caucasians;CD4 Positive T Lymphocytes;co-infection;Collaborations;design;Doctor of Philosophy;Educational workshop;Enrollment;Europe;experience;Faculty;Funding;Future;Genetic Transcription;Genetic Variation;Ghana;graduate student;Grant;Hepatitis;HIV;HIV-2;Immunologics;Laboratory Research;Malaria;Manuscripts;Medical Research;memory CD4 T lymphocyte;Mentors;Mentorship;Patients;Persons;Postdoctoral Fellow;programs;Proviruses;Recombinants;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Scientist;Site;skills;social situation;Students;success;T cell response;Training;Training Programs;Tuberculosis;United States National Institutes of Health;Universities;Viral;Viral reservoir;Virus Latency;Washington;Writing

PROJECT_TITLE: HIV Basic Science and Cure Research Training for Scientists at the University of Ghana (H-Cure-RT)


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Slip and fall accidents are a significant source of occupational injuries leading to personal and economic harm for workers and their families. The development of tools to inform better selection of slip-resistant shoes and timely replacement of worn shoes is expected to reduce slip and fall accidents. The purpose of this research is to develop and validate these tools.

PI_NAMEs: BESCHORNER, KURT E (contact);SOMMERICH, CAROLYN M

PROJECT_TITLE: Preventing Slips in Food Service: Development of Tools for Shoe Selection and Replacement

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


ORG_CITY: PULLMAN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative This research project will specifically focus on the development of a low-cost and highly sensitive multiplex biosensor system integrated with a smartphone readout that can rapidly and accurately analyze a panel of wood smoke biomarkers from dual biological media (blood and urine) at anticipated low concentrations. This approach will enable a more accurate prediction of occupational exposures to wood smoke, and provide better analytical performance (e.g., sensitivity, dynamic range, detection limit, reliability, accuracy and speed) as well as operational performance (user-friendly design) for early detecting biomarkers than current methods. Once validated, the multiplex sensor platform will represent the next-generation quantitative tool for measuring mixed occupational exposures, which is fully consistent with the goals of the NIOSH Research to Practice (r2P) initiative.

PI_NAMEs: DU, DAN  (contact);NAEHER, LUKE P;SIMPSON, CHRISTOPHER D

PROJECT_TITLE: Multiplexed Sensors for Biomonitoring of Wood Smoke Exposure among Wildland Firefighters


ORG_CITY: DALLAS

ORG_NAME: BAYLOR RESEARCH INSTITUTE

PHR: The occupational stress of fire fighting, which includes frequent exposure to psychological trauma, results in a substantial proportion of career fire fighters experiencing disabling mental health consequences. An evidence-based, peer-delivered curriculum for preventing mental health challenges in fire service recruits – the Brief Unified Protocol (BUP) -- will be a culturally competent, exportable, and efficient prevention intervention if demonstrated superior to an educational training that is similar to standard practice in Fire Academies. The objective of this research is to increase the resilience of the Nation’s Fire Service through expanding 40 years of emotional regulation research to a real-world, prevention-focused application.

PI_NAMEs: GULLIVER, SUZY B (contact);MEYER, ERIC CHRISTOPHER

PROJECT_TITLE: Peer Delivered, Emotion Regulation-Focused Mental Health Prevention Training for Fire Fighter Trainees


ADMINISTERING_IC: GH

IC_NAME: Center for Global Health

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: NARRATIVE The proposed research is relevant to public health because it offers new and improved strategies to efficiently and accurately diagnose the etiology of acute febrile illness, a requisite for effective disease control and treatment. The proposed research is relevant to the US Centers of Disease Control and Prevention as it will inform regional assessments and demonstrate a pathway for implementation of improved diagnostics by key stakeholders in a region that is highly endemic for emerging infectious diseases.

PI_NAMEs: KOSEK, MARGARET N (contact)

PROJECT_TITLE: GH20-005, Conducting Integrated Infectious Disease and Public Health Research in Peru


ORG_CITY: LIMA

ORG_COUNTRY: PERU

ORG_FIPS: PE

ORG_NAME: UNIVERSIDAD PERUANA CAYETANO HEREDIA

PHR: Project Narrative Peru and Ecuador are at high risk of acute febrile illness outbreaks; however, the specific causes of acute febrile illness remain there largely unknown, limiting control measures optimized to the specific diseases, and thus the effectiveness of the public health responses. In close coordination with key offices of the Ministries of Health, our Project of Febrile Illness Surveillance in the Andean and Amazon Countries (“PISAAC”) proposes to study the etiology and epidemiology of acute undifferentiated febrile illness in strategically selected regions of Peru and Ecuador, strengthening the capacities and services for diagnosis, and the specific outbreak-oriented training of the appropriate workforce. As the surveillance platform implemented by PISAAC should serve to additional health problems, we will extend its use to antimicrobial resistance, and acute diarrheal diseases.

PI_NAMEs: GOTUZZO, EDUARDO  (contact)

PROJECT_TITLE: RFA-GH-20-005, Project of Febrile Illness Surveillance in the Andean and Amazon Countries (PISAAC)


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative This project will result in the pilot validity and feasibility testing of a novel, non-invasive device for screening high-risk patient populations for anemia, and assist in differentiating between hemolytic and non-hemolytic causes. Anemia remains pervasive public health issue, which affects one third of the world’s population, particularly in pregnant women and adolescent girls. There is an urgent need for an effective, non-invasive tool to combat this issue.

PI_NAMEs: JUDKINS, ALLISON  (contact)

PROGRAM_OFFICER_NAME: CLARK, DAVID

PROJECT_TERMS: 12 year old;acceptability and feasibility;Adolescent;Adult;Affect;Africa;Age;Anemia;antenatal care;Asia;Attention;Blood;Blood Tests;brain metabolism;burden of illness;Carbon Monoxide;Child;Chronic;Classification;Clinical;clinical decision-making;clinically relevant;Color;combat;Community Health;Community Health Aides;cost;Country;Data;Decision Making;Development;Devices;Diagnosis;Diagnostic;diagnostic tool;Disease;effective therapy;Evaluation;Exhalation;Feasibility Studies;feasibility testing;Female Adolescents;Fetus;Government;Health;Health care facility;health economics;Hemoglobin;Hemoglobin concentration result;Hemolytic Anemia;high risk;improved;in vivo;Incidence;India;Infant;instrument;Iron;low and middle-income countries;Low Birth Weight Infant;Maternal Mortality;maternal risk;Measurement;Measures;Methods;minimally invasive;Morbidity - disease rate;mortality;Mothers;Non-Invasive Detection;novel;Nutritional;Outcome;patient population;Patient Recruitments;Patients;Perception;Physical Examination;point of care;Population;portability;Predictive Value;Pregnancy;pregnant teen;Pregnant Women;Premature Birth;Prevalence;Process;productivity loss;Provider;Public Health;Reference Standards;Resource-limited setting;Resources;Running;Rural;screening;screening program;Skin;Skin Pigmentation;Small for Gestational Age Infant;Specificity;standard of care;Surveys;System;tertiary care;Testing;tool;Training;Validation;Variant;Visual;Vulnerable Populations

PROJECT_TITLE: Accuracy and Feasibility of Non-Invasive Anemia Screening Assistant (ASIST) Device in Resource-Limited Settings

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ATHENS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Aminoglycoside antibiotics (AGAs) are potent antibiotics which have long been used as potent broad spectrum antibiotics, with targets including gram-negative pathogens, MRSA, MDR-TB, and complex infectious diseases such as hospitalized CAPD and exacerbated CF. Significant limitations of the AGAs, however, are AGA-induced permanent hearing loss (ototoxicity) and nephrotoxicity which are reported to affect up to 20% of the patient population, and susceptibility to resistance due AGA and target modifying enzymes. On the basis of recent advances in the understanding of the molecular basis for AGA-induced ototoxicity, and existing knowledge of the mechanisms of resistance, this proposal seeks to design, and synthesize novel AGAs that do not suffer from the complications of toxicity, are not subject to common mechanisms of resistance, and to evaluate them both in vitro and in animal models for efficacy against gram-positive an gram-negative organisms, and lack of ototoxicity and nephrotoxicity.

PI_NAMEs: CRICH, DAVID  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Affect;Aminoglycoside Antibiotics;Aminoglycosides;analog;Animal Model;Anti-Bacterial Agents;Antibiotic Therapy;Antibiotics;apramycin;bacterial resistance;Biological;Biological Assay;Cell Line;Clinic;clinical application;Cochlea;Communicable Diseases;Complex;Continuous Ambulatory Peritoneal Dialysis;cytotoxicity;Derivation procedure;design;Development;Didelphidae;Disease Resistance;Drug Kinetics;Drug resistance;Engineering;Enzymes;ESKAPE pathogens;Feedback;Genes;Goals;Gram-Negative Bacteria;guinea pig model;Hospitalization;Human;improved;In Vitro;in vivo;in vivo evaluation;Investigation;kidney cell;Knowledge;methicillin resistant Staphylococcus aureus;Methyltransferase;Modeling;Modification;Molecular;Multi-Drug Resistance;Multidrug-Resistant Tuberculosis;Multiple Bacterial Drug Resistance;Mus;nephrotoxicity;next generation;novel;Organism;ototoxicity;Parents;Paromomycin;pathogen;patient population;permanent hearing loss;Positioning Attribute;Predisposition;Property;Protein Isoforms;Pseudomonas aeruginosa;Rattus;Reporting;Resistance;resistance mechanism;Ribosomes;Series;Shapes;single molecule;Skeleton;Time;Toxic effect;Toxicology;Transferase;whole genome

PROJECT_TITLE: Shaping Next Generation Aminoglycoside Antibiotics for Treatment of Multidrug-Resistant Diseases

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: RELEVANCE (See instructions):  People living with HIV/AIDS remain untreated and more become newly infected each year. Many testing,  treatment, and prevention methods exist, raising critically important questions about which strategies to  employ when, where, and for whom, given varying epidemic features and resource constraints. We will  expand the CEPAC-I Model to address questions related to the impact of novel treatment and prevention  options and to determine which combinations of interventions will optimize HIV health outcomes globally.

PI_NAMEs: FREEDBERG, KENNETH ALAN (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS prevention;antiretroviral therapy;Botswana;Brazil;Budgets;Caring;Characteristics;Clinical;clinical care;clinical implementation;Clinical Trials;Computers;Continuity of Patient Care;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness evaluation;Country;Data;design;Developing Countries;Development;Educational Status;Epidemic;experience;Face;financial incentive;Funding;Gender;Genotype;Goals;Guidelines;Health;high risk population;HIV;HIV Infections;HIV/AIDS;Human immunodeficiency virus test;improved;Incidence;innovation;insight;Instruction;International;Intervention;Ivory Coast;Life Expectancy;Methods;Modeling;models and simulation;Morbidity - disease rate;mortality;Natural History;NIH Office of AIDS Research;novel;Outcome;pandemic disease;Persons;Policies;Policy Maker;Population;pre-exposure prophylaxis;prevent;Prevention;preventive intervention;programs;Prostitution;Publishing;Randomized, Controlled Trials;Reduce health disparities;Research;Research Priority;research study;Resistance;Resource Allocation;Resource-limited setting;Resources;Schedule;Services;Sex Orientation;simulation;skills;South Africa;Testing;transmission process;treatment guidelines;treatment program;treatment response;Work;young woman;Zimbabwe

PROJECT_TITLE: Optimizing HIV Care in Less Developed Countries


ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Narrative Aberrant changes in chromatin regulatory enzymes are commonly found in human malignancies including cancer. Elucidating the molecular mechanism that regulates activities of chromatin regulatory enzymes is essential to understand how they contribute to cancer pathogenesis and identify novel and effective rational therapies.

PI_NAMEs: CHO, UHN-SOO ;DOU, YALI  (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Affect;ASH2L gene;Biochemical;Biological;cancer diagnosis;cancer initiation;cancer therapy;Cells;Chromatin;Chromatin Remodeling Factor;Complex;Cryoelectron Microscopy;Data;Deposition;Disease;DNA biosynthesis;driver mutation;Elements;Enzymes;Epigenetic Process;epigenetic regulation;epigenomics;Event;Evolution;Family;Gene Expression;Genetic Transcription;Heterogeneity;histone methyltransferase;Histones;Human;In Vitro;insight;Malignant Neoplasms;Mediating;Methylation;Mission;Mixed-Lineage Leukemia;MLL gene;Molecular;Molecular Conformation;multidisciplinary;Mutation;National Cancer Institute;Neoplasm Metastasis;new therapeutic target;novel;Nucleosome Core Particle;Nucleosomes;particle;Pathogenesis;Play;Post-Translational Protein Processing;Protein Dynamics;protein protein interaction;Proteins;Recombinants;reconstitution;Regulation;Resolution;Role;Shapes;Structural Models;Structure;Tail;Testing;therapeutic biomarker;Transcriptional Activation;Transcriptional Regulation;Visualization

PROJECT_TITLE: Structural insights into the MLL core complexes

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Structural racism, defined as the laws, policies, institutional practices, and entrenched norms embedded within society that foster discrimination through mutually reinforcing inequitable systems, has been indicated as a root cause of inequities in health outcomes including those related to diabetes. One form of structural racism, historic redlining, known as the practice of denying resources to communities based on race, has been shown to impact health outcomes; however, the relationship between historic redlining and contemporary diabetes outcomes has not been well-studied. Therefore, this study will address this gap in knowledge by using an experimental convergent mixed methods design to (1) understand the relationship between historic redlining and diabetes-related outcomes among adults with type 2 diabetes based on their lived experiences, (2) quantify the direct and indirect pathways through which historic redlining impacts diabetes-related outcomes; and (3) conduct hierarchical modeling to assess a) the impact of individual, interpersonal, and neighborhood level factors on individual level diabetes outcomes, b) the contribution of historic redlining exposure toward neighborhood level associations, and c) whether individual level associations are moderated by historic redlining.

PI_NAMEs: WILLIAMS, JONI STROM (contact)

PROGRAM_OFFICER_NAME: ARTIS DICKERSON, SHAVON

PROJECT_TERMS: 18 year old;Address;Adult;Area;Attitude;Behavior;behavioral outcome;Belief;Black race;Blood Glucose;blood pressure control;Body mass index;Caring;Chronic;Classification;Clinical;Communities;Data;design;diabetes management;Diabetes Mellitus;diabetes self-management;Diagnosis;Diet;digital;Discrimination;Disparity;economic disparity;Economics;Education;Employment Opportunities;Environment;ethnic minority population;Ethnic Origin;Fostering;Gender;glucose monitor;glycemic control;Green space;Health;health care availability;Health Food;health inequalities;Healthcare;Housing;Individual;Inequity;Institutional Practice;Interview;Knowledge;Laws;Lipids;Lived experience;medication compliance;Methods;Minority Groups;Modeling;Morbidity - disease rate;mortality;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Outcome;Pathway interactions;Persons;Physical activity;Policies;Population Group;population health;Poverty;Process Measure;Qualitative Research;Quality of life;Race;racial minority population;Racial Segregation;Recreation;Reporting;Research Design;Research Methodology;Resources;Risk;Role;Scholarship;Security;segregation;Self Care;sex;social;social disparities;social health determinants;Societies;Structural Racism;Structure;System;Transportation;United States;urban setting;Variant

PROJECT_TITLE: The Role of Structural Racism on Disparities in Clinical Outcomes for Diabetes: A Mixed Methods Study

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE By taking advantage of an existing cohort study that is unique in having collected multiple 24-hour urine samples from over 100,000 adults, this project has the potential to convincingly settle the debate on whether a sodium intake below the population average is associated with higher mortality. This contribution is important because if sodium intake below the population average is associated with higher mortality, then salt reduction efforts should only focus on those who consume high levels of sodium, rather than the entire population. The proposed research is, thus, relevant to public health because it will help clarify dietary guidelines on salt and whether population-wide efforts, such as broad reformulation of the food supply, may cause harm among a large proportion of the population.

PI_NAMEs: GELDSETZER, PASCAL  (contact)

PROGRAM_OFFICER_NAME: HONG, YULING

PROJECT_TERMS: Adult;Affect;Blood Pressure;blood pressure reduction;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cessation of life;cohort;Cohort Analysis;Cohort Studies;comparative;Consumption;Data;design;dietary guidelines;Event;follow-up;Food Supply;Formulation;Health;healthy aging;high risk;Hour;Individual;Intake;Measures;mortality;mortality risk;Netherlands;Participant;Population;population based;Potassium;Public Health;randomized trial;Reporting;Research;Research Personnel;Risk;Sample Size;Sampling;Shapes;Sodium;Sodium Chloride;Spottings;stem;Testing;Time;Urine

PROJECT_TITLE: The relationship between sodium intake and mortality: a case-cohort study in a population-based cohort of 148,000 adults with both 24-hour and spot urine samples

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ORG_CITY: BUFFALO

ORG_NAME: NEUROVASCULAR DIAGNOSTICS, INC.

PHR: Narrative  In this Phase II proposal, Neurovascular Diagnostics aims to develop a blood-based RNA expression diagnostic to assess intracranial aneurysm rupture risk. To do this, we will validate our preliminary expression- based risk biomarker (successfully developed in Phase I) in a new dataset of sequencing data (n=200), standardize the assessment of the biomarker on an established clinical testing platform, and then test the developed, research-use-only assay in a large prospective cohort of 600 patient blood samples collected from 5 centers across the US. Successful completion of this study will produce an aneurysm risk blood test that will enable more vigilant aneurysm management and low-cost, non-invasive monitoring of patients during watchful waiting or between follow-up imaging after treatment.

PI_NAMEs: POPPENBERG, KERRY  (contact);TUTINO, VINCENT MATTHEW

PROGRAM_OFFICER_NAME: AUBRECHT, TARYN GRACE

PROJECT_TERMS: Aftercare;Age;Algorithms;Aneurysm;Biological;Biological Assay;Biological Markers;Blood;Blood specimen;Blood Tests;Blood Vessels;Capillary Electrophoresis;Characteristics;Chemicals;Classification;Clinical;clinical practice;cohort;Complication;cost;Dangerousness;Data;Data Set;Death Rate;demographics;design;Detection;Development;Diagnostic;Diagnostic tests;Digital Subtraction Angiography;Dose;Event;Face;feature selection;follow-up;Gene Expression Profile;gene panel;Genes;Genetic Markers;Genetic Transcription;Growth;high risk;Hypertension;Image;Intervention;Intracranial Aneurysm;large datasets;Lifelong disability;Ligation;machine learning classifier;Medical Imaging;Microsurgery;model development;Modeling;molecular diagnostics;Monitor;neurovascular;non-invasive monitor;Output;Pathology;Patient Monitoring;Patient observation;patient subsets;Patients;Performance;Persons;Phase;Population;prospective;Prospective cohort;Prospective Studies;prototype;Research;research clinical testing;Risk;Risk Assessment;risk prediction model;risk stratification;RNA;Rupture;Ruptured Aneurysm;Sample Size;Sampling;Scanning;Signal Transduction;Site;Small Business Innovation Research Grant;Specificity;Standardization;Subarachnoid Hemorrhage;Survivors;Testing;Training;transcriptome;transcriptome sequencing;Translating;Validation;validation studies;vascular inflammation;Whole Blood;Work

PROJECT_TITLE: Development of a Molecular Diagnostic to Identify Dangerous Intracranial Aneurysms


PHR: PROJECT NARRATIVE Dysregulation of GPCR signaling leads to several diseases, yet the molecular mechanisms remain poorly understood. The objective of this project is to elucidate the molecular mechanisms that govern GPCR signaling by canonical and non-canonical mechanisms. We expect to define novel paradigms of GPCR signaling with the hope of identifying new targets to modulate GPCR signaling for therapeutic development.

PI_NAMEs: MARCHESE, ADRIANO  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: A kinase anchoring protein;Address;Automobile Driving;beta-arrestin;Biochemical;Biological Assay;Biophysics;Cell Culture Techniques;Cessation of life;chemokine receptor;Confocal Microscopy;CXC Chemokines;Disease;drug discovery;Embryonic Development;Family;Fluorescence;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Goals;human disease;immune function;innovation;Knowledge;Label;Ligation;live cell imaging;Malignant Neoplasms;Modeling;Molecular;novel;Physiological Processes;Play;Prognosis;receptor;receptor binding;Receptor Signaling;reconstitution;Regulation;Research;Role;Signal Transduction;stem cells;structural determinants;Therapeutic;therapeutic development;Translating

PROJECT_TITLE: Regulation of chemokine receptor signaling

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]