ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: We propose a systematic approach to study SARS-CoV adaptations through a Systems Biology Lens (SYBIL) in order to generate predictive models of SARS-CoV pathogenesis which will a) allow us to identify biomarkers for predicting disease outcome, b) reveal changes associated with human adaptation and c) provide avenues to explore for new, host-directed, therapeutic interventions.

PI_NAMEs: GARCIA-SASTRE, ADOLFO  (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: 2019-nCoV;Animal Model;Animals;Anti-viral Response;Appearance;Bioinformatics;Biological;Biological Markers;biomarker identification;Blood;Cells;Cessation of life;Chiroptera;Clinical;Clinical Trials;clinically relevant;cohort;Communities;companion diagnostics;Coronavirus Infections;COVID-19;COVID-19 pandemic;COVID-19 severity;cross-species transmission;Data;data integration;data management;Data Set;Diabetes Mellitus;Disease;disease model;Disease Outcome;Disease Progression;Epigenetic Process;epigenome;Experimental Models;functional genomics;Generations;Genes;Genetic Screening;Human;Immune response;immunological status;improved;in vivo;induced pluripotent stem cell;Infection;Influenza;Influenza A virus;influenza infection;influenzavirus;insight;Integration Host Factors;Intervention;lens;Lighting;Link;machine learning algorithm;Measurement;metabolome;Modeling;Molecular;Molecular Profiling;mouse model;multidisciplinary;multiple omics;Mus;mutant;network models;new therapeutic target;next generation;novel;novel therapeutics;novel virus;Obesity;Outcome;pandemic disease;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patients;personalized medicine;Pharmaceutical Preparations;predictive marker;predictive modeling;Process;programs;Progress Reports;protein expression;Proteome;Proteomics;Research;respiratory;response;Risk Assessment;Sampling;SARS coronavirus;SARS-CoV-2 infection;Severity of illness;Source;Specific qualifier value;System;Systems Biology;targeted treatment;Technology;Testing;Therapeutic Intervention;therapeutic target;Tissues;transcriptome;transcriptomics;Tropism;Vaccination;Validation;Variant;Viral;Viral Proteins;Virus;Virus Diseases;virus host interaction;Virus Replication;Zoonoses


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_STATE: NY

PROJECT_TERMS: Adherence;Bioinformatics;Charge;Collaborations;Communicable Diseases;Data;data dissemination;data exchange;data management;data sharing;Decision Making;experience;experimental study;Human Resources;Influenza;Infrastructure;Laboratories;lens;Manuscripts;meetings;member;Mission;Modeling;Monitor;National Institute of Allergy and Infectious Disease;next generation;organizational structure;Performance;Policies;Preparation;programs;Progress Reports;Protocols documentation;Reagent;Research;Research Personnel;Resolution;Resource Allocation;Resources;response;Sampling;SARS coronavirus;Scientist;Services;Site Visit;Structure;student training;symposium;Systems Biology;Technology;Training;training opportunity;Training Programs;Travel;Viral Pathogenesis;Virus

PROJECT_TITLE: Core A - Administrative Core


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Heart Disease;Mental Health;Prevention;Rehabilitation

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Recent advances in treatment for cardiac arrest (CA) have allowed patients to survive neurologically intact, but 1 in 3 report high negative psychological factors (NPF; e.g., depression, posttraumatic stress disorder) at hospital discharge that may increase risk for poor recovery marked by low health-related quality of life (QoL) and lack of independence in activities of daily living (ADL) as well as dangerously reduced cardiac vagal control, which is an index of the health of the autonomic nervous system that predicts risk for future cardiovascular events and mortality. Although NPF cannot be prevented, modifiable positive psychological factors (PPF; e.g., optimism, positive affect, and purpose in life) predict improved recovery and physical activity (PA) in non-CA patients, and therefore this study will test whether PPF predict long-term post-CA recovery—independent of NPF—and whether PA may be a behavioral mechanism underlying these associations. There are currently no clinical practice guidelines for identifying either cardioprotective or harmful psychological factors after CA because there is currently little evidence to guide clinicians, so the proposed research will represent a first step toward developing standard psychosocial interventions with a focus on positive psychological resources and negative psychological risk factors to improve recovery after CA.

PI_NAMEs: BIRK, JEFFREY LEE (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: actigraphy;Activities of Daily Living;Acute;acute care;Affect;American Heart Association;Autonomic nervous system;Awareness;Behavior;Behavioral Mechanisms;Behavioral Medicine;Belief;Cardiac;Cardiac Death;Cardiac health;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cause of Death;Characteristics;Chest;Clinical Practice Guideline;cohort;Dangerousness;depressive symptoms;Development;disability;Disease;Distress;Ecological momentary assessment;Enrollment;ethnic diversity;Event;experience;follow up assessment;Frequencies;Future;Health;Health Campaign;health related quality of life;Healthcare;Heart;Heart Arrest;heart rate variability;heart rhythm;Hospitalization;Hospitals;Hour;Human;Impairment;Implantable Defibrillators;Implantation procedure;improved;indexing;infancy;Inpatients;Intensive Care Units;interest;Intervention;Life;Link;Literature;long term recovery;Long-Term Survivors;Measures;Medical;Mental Depression;Methods;Monitor;mortality;mortality risk;Myocardial Infarction;negative affect;Neurologic;New York;observational cohort study;optimism;Outcome;Participant;patient population;patient screening;Patients;Persons;Physical activity;Population;Post-Traumatic Stress Disorders;Predictive Factor;Presbyterian Church;prevent;primary outcome;prospective;Psyche structure;psychologic;psychological distress;Psychological Factors;Psychological Tests;psychosocial;Public Health;Quality of life;racial diversity;Recording of previous events;Recovery;recruit;Reporting;Research;Resources;Risk;Risk Factors;risk prediction;Role;Sampling;Shapes;Stroke;sudden cardiac death;Surveys;Survival Rate;Survivors;survivorship;Symptoms;System;Telephone;Testing;Ventricular Arrhythmia;Work;Wrist

PROJECT_TITLE: Positive and Negative Psychological Predictors of Long-Term Recovery after Cardiac Arrest

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: We propose a two-arm randomized controlled trial to evaluate the impact of a multicomponent electronic health record intervention on racially-informed guideline concordant care for patients with poorly-controlled hypertension. The interventions tested in this trial aim to reduce health disparities in racial and ethnic minorities by using provider disparities report cards, electronic decision support, and enhanced patient portals and communication materials. Findings from this trial will provide important insight into whether a multicomponent racially-informed intervention leveraging health information technology can reduce health disparities.

PI_NAMEs: CHOUDHRY, NITEESH K (contact);LAUFFENBURGER, JULIE CHRISTINE

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: 2 arm randomized control trial;Address;Adopted;Adoption;Adult;Advocate;Affect;Anti-Hypertensive Agents;Area;arm;barrier to care;behavior change;Behavioral Sciences;Black Populations;Blood Pressure;blood pressure control;Caring;Chicago;Clinic;clinical decision support;clinical practice;Clinical Trials;Cluster randomized trial;Communication;Data;design;Disparity;disparity reduction;Drug Prescriptions;effectiveness/implementation hybrid;Electronic Health Record;electronic health record system;Electronics;Ensure;ethnic disparity;ethnic minority;experience;Focus Groups;follow-up;Grant;Guidelines;Health;health disparity;health information technology;Healthcare Systems;Heart Diseases;Hispanic;Home Blood Pressure Monitoring;hybrid type 2 trial;Hypertension;hypertension control;Illinois;implementation evaluation;improved;Individual;innovation;insight;Intervention;Latino Population;medical specialties;Minority;Minority Groups;minority patient;multi-ethnic;multidisciplinary;Not Hispanic or Latino;Oral;Patient Care;patient outreach;patient population;patient portal;patient-clinician communication;Patients;Physicians;pilot test;Pragmatic clinical trial;pragmatic trial;primary outcome;Provider;provider behavior;Quality of Care;Race;racial difference;racial disparity;racial diversity;racial minority;Randomized;randomized trial;Recommendation;recruit;Reduce health disparities;Reporting;research study;Resources;routine care;secondary outcome;Social Work;Stroke;study population;Subgroup;technology intervention;Testing;Time;tool;treatment arm;treatment as usual;Triage;trial comparing;Visit

PROJECT_TITLE: Leveraging electronic health record tools to reduce health disparities for patients with uncontrolled hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-A(56)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases

PROJECT_TERMS: 2019-nCoV;3-Dimensional;A549;Affinity Chromatography;Animal Model;Architecture;Area;ATAC-seq;Attenuated;Bacterial Artificial Chromosomes;Bioinformatics;biomarker identification;Biomedical Research;California;cell immortalization;Cell Line;Cell Nucleus;Cells;ChIP-seq;Chiroptera;chromatin modification;Clinical Data;cohort;Collaborations;Coronavirus;Coronavirus Infections;coronavirus treatment;COVID-19;crosslink;Data;data integration;data management;Data Set;Deletion Mutation;Deposition;design;diagnostic development;Disease;DNA-Protein Interaction;Ensure;Epigenetic Process;Equipment;Evolution;Follow-Up Studies;Gene Deletion;Gene Expression;Generations;Genetic Services;Genomics;Goals;Hi-C;Human;Immune response;In Vitro;in vivo;Individual;Infection;Infrastructure;innovation;Integration Host Factors;International;Label;Leadership;lens;Luciferases;Maps;Mass Spectrum Analysis;medical schools;member;Methodology;Modeling;Molecular;Molecular Probes;Mus;mutant;new therapeutic target;novel;novel strategies;pathogen;Pathogenesis;Pathology;Patients;Phenotype;Phosphorylation;Point Mutation;Positioning Attribute;Post-Translational Protein Processing;predictive marker;Process;protein protein interaction;Protein-Protein Interaction Map;Proteins;Proteomics;Protocols documentation;recombinant virus;Recombinants;Regulatory Element;Reporter;Reporter Genes;Reproducibility;Research Institute;Research Personnel;Research Project Grants;Research Support;reverse genetics;Role;Sampling;SARS coronavirus;SARS-CoV-2 infection;SARS-CoV-2 variant;Services;Severity of illness;Signal Transduction;Standardization;success;Support System;System;Systems Biology;Technology;technology development;Texas;Therapeutic;Therapeutic Intervention;Tissues;tool;transcriptome sequencing;transcriptomics;transmission process;Tropism;Universities;Vaccination;Variant;Venus;Viral;Viral Genes;Viral Proteins

PROJECT_TITLE: Core B - Technology Core


ADMINISTERING_IC: AA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PI_NAMEs: LAURIENTI, PAUL  (contact)

PROJECT_TERMS: Adolescence;Adolescent;Alcohol consumption;alcohol misuse;alcohol research;alcohol use disorder;Alcohols;American;Back;Behavior Therapy;Behavioral;Biological Markers;Brain;brain based;Brain imaging;Cessation of life;Data;Data Collection;Data Set;Development;Diagnostic;Disease;drinking;drinking behavior;emerging adult;Evaluation;experience;Future;Genetic;Goals;hazardous drinking;Human;Individual;Interdisciplinary Study;interest;Intervention;Knowledge;late life;learned behavior;Life;longitudinal dataset;Longitudinal Studies;Machine Learning;machine learning prediction;markov model;Medial;Network-based;neural;neural circuit;Neurobiology;neurodevelopment;neuroimaging;neuroregulation;noninvasive brain stimulation;Outcome;Pathway Analysis;Patients;Phenotype;Placebos;Positioning Attribute;Pre-Clinical Model;Predictive Analytics;Prefrontal Cortex;premature;Probability;prognostic assays;Recording of previous events;Research;Research Design;resilience;Rest;Rodent;Slide;Study models;Therapeutic;Time;Transcranial magnetic stimulation;Translating;treatment strategy;United States

PROJECT_TITLE: Project 1: Dynamic functional brain network phenotypes associated with vulnerability to hazardous alcohol consumption


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE A central tenet of neuroscience is that memory storage involves changes in the functional properties of neuronal networks and that memory deficits are associated with disruptions in network function. Studies outlined in this proposal will use a relatively complex, yet tractable, neuronal network to examine the distributed representation of the memory for operant conditioning, a ubiquitous form of associative learning in which a subject learns from the consequences of its behavior. A deeper understanding of the design principles that govern the implementation of mnemonic mechanisms in neuronal networks may help guide the development of better treatments for neural dysfunction, and thereby improve human brain health.

PI_NAMEs: BYRNE, JOHN H (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;analog;Aplysia;Association Learning;Behavior;Behavioral;Biological Models;biophysical analysis;Biophysics;Brain;brain health;Cell Physiology;Cells;Chemical Synapse;Complex;Computer Models;Coupling;design;Development;dimension reduction;Dimensions;Electrical Synapse;Electrophysiology (science);Environment;Event;Exhibits;extracellular;feeding;Feeding behaviors;Goals;Hodgkin-Huxley model;Human;Image;improved;In Vitro;in vitro activity;in vivo;Individual;Inhibitory Synapse;insight;Invertebrates;Knowledge;Learning;long term memory;Mediating;Memory;memory encoding;Memory impairment;memory retention;Methods;Modeling;Molecular;Motor;neural circuit;neural patterning;Neuronal Dysfunction;Neuronal Plasticity;Neurons;Neurosciences;Operant Conditioning;Output;Pattern;Phenotype;Population;Process;Property;Protocols documentation;reinforced behavior;Resolution;Role;shared memory;Short-Term Memory;Site;Specificity;Synapses;Synaptic plasticity;synergism;System;Techniques;Training;voltage sensitive dye;Work

PROJECT_TITLE: Analyses of the Distributed Representation of Associative-Learning in an Identified Circuit Using a Combination of Single-Cell Electrophysiology and Multicellular Voltage-Sensitive Dye Recordings


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Coronaviruses;Data Science;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: 2019-nCoV;Acceleration;analysis pipeline;Bioinformatics;bioinformatics tool;Collaborations;Communicable Diseases;Communities;computer framework;Computer software;computerized tools;COVID-19 pandemic;Data;data access;Data Analyses;data dissemination;data exchange;data integration;data management;data reuse;Data Set;data sharing;Dedications;design;Development;digital;Elements;Ensure;experimental study;flexibility;Funding;Goals;Guidelines;improved;Infrastructure;innovation;large scale data;lens;Maintenance;member;Meta-Analysis;Metadata;Mission;Modeling;National Institute of Allergy and Infectious Disease;novel therapeutic intervention;pathogen;Pathway interactions;predictive modeling;Process;programs;Protocols documentation;public repository;Publications;Quality Control;Reagent;Recommendation;Reporting;repository;Reproducibility;Research;Research Personnel;Resources;Sampling;SARS coronavirus;Secure;software infrastructure;Source Code;Structure;Support System;System;Systems Analysis;Systems Biology;Systems Development;Technology;tool;Training Programs;Visualization;web site;web-based tool;working group

PROJECT_TITLE: Core D - Data Management and Bioinformatics Core


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The focus of this project is to understand the catalytic mechanism of the metalloenzyme nitrogenase. Nitrogenase is the only biological agent that can reduce atmospheric dinitrogen into a bioavailable form (ammonia) and therefore has an immense global impact on human health and welfare through supporting the agricultural/nutritional needs of ~3 billion people. It is also a unique model enzyme that couples biological redox catalysis with ATP-dependent energy transduction processes, which are both central to cellular metabolism.

PI_NAMEs: TEZCAN, FAIK AKIF (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Mechanism of Energy Transduction and Substrate Activation in Biological Nitrogen Fixation

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Narrative To lessen the negative impact of drug-resistant epilepsy on children and improve their surgical outcomes, novel methods are needed to augment the EEG interpretation - especially when invasively recorded – and to estimate the epileptogenic zone, without requiring the recording of unpredictable seizures (which can be difficult to capture and interpret in many cases). The proposed study is relevant to public health because, if successful, it will provide the community with a new approach to estimate the epileptogenic zone, which goes far beyond the traditional identification of frank epileptiform activity on the EEG and can complement the techniques that are currently used to define an optimal resection strategy in children undergoing epilepsy surgery. The project is relevant to the NINDS's mission because the resulting findings can augment the surgical treatment of children with drug-resistant epilepsy and significantly improve their quality of life, since successful epilepsy surgery represents the best opportunity for these patients to avoid lifetime disability, recover function, and improve cognition.

PI_NAMEs: TAMILIA, ELEONORA  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Address;analytical method;Area;Biological Markers;Boston;Brain;Brain region;Characteristics;Child;Child Care;Clinical;clinical care;Cognition;Communities;Complement;Complex;Computer Assisted;Coupling;Data;disability;Disease;Electroencephalography;Electrophysiology (science);Epilepsy;epileptiform;Evaluation;Excision;experience;FarGo;Freedom;Frequencies;Goals;graph theory;Human;improved;Information Networks;Intractable Epilepsy;Life;Link;Logistic Regressions;Measures;Methodology;Methods;Mission;Monitor;National Institute of Neurological Disorders and Stroke;neuroimaging;neurosurgery;novel;novel strategies;Operative Surgical Procedures;Outcome;Pathologic;Patients;Pattern;Pediatric Hospitals;Performance;Phase;predictive modeling;prevent;Property;Public Health;Quality of life;Reader;Reading;Research;Retrospective Studies;Risk;ROC Curve;Seizures;signal processing;Signal Transduction;success;surgery outcome;Techniques;Testing;Tissues;Visual

PROJECT_TITLE: Combining Brain Connectivity and Excitability to Plan Epilepsy Surgery in Children: A New Approach to Augment Presurgical Intracranial Electroencephalography

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Mental Health;Neurosciences;Prevention;Substance Misuse

PI_NAMEs: CZOTY, PAUL W. (contact)

PROJECT_TERMS: Abstinence;Address;Alcohol consumption;alcohol research;alcohol use disorder;Alcoholic beverage heavy drinker;behavior test;Behavioral;Brain;Brain imaging;Brain region;Characteristics;Chronic;clinically relevant;Cognitive;cognitive ability;cognitive function;cognitive testing;Consultations;cost;Cues;Data;discounting;Discrimination;drinking;effective intervention;efficacy evaluation;Environmental Risk Factor;Ethanol;flexibility;Functional Magnetic Resonance Imaging;Funding;Future;gray matter;Heavy Drinking;Home;Human;human subject;Image;imaging study;improved;Impulsivity;Intake;Knowledge;Light;Long-Term Effects;Macaca fascicularis;Magnetic Resonance Imaging;male;Measures;Mediating;Modeling;Monkeys;neural;Neurobiology;nonhuman primate;novel;Patients;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Population;Positioning Attribute;pre-clinical;Prevention strategy;Preventive;Public Health;Punishment;Quinine;Recovery;Relapse;Research Design;resilience;Resistance;Rest;Rodent;Self Administration;social;Social Behavior;Social Dominance;software development;Stimulus;Structure;Technology;Time;touchscreen;translational approach;Translations;treatment strategy;Vulnerable Populations;white matter;Work

PROJECT_TITLE: Project 2: Mechanisms underlying vulnerability to ethanol self-administration: behavioral and brain imaging studies in group-housed monkeys


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Prevention

PROJECT_TERMS: Affect;artificial intelligence model;Benign;Bioinformatics;Biological Process;Cessation of life;Chiroptera;Clinical;Collaborations;Coronavirus;COVID-19;COVID-19 severity;Data;data management;Data Set;Development;Disease;Disease Marker;Disease Outcome;Event;Genes;Genetic Transcription;heuristics;Hospitalization;Human;human data;Immune response;improved;in vivo;Infection;Inflammatory;Innate Immune Response;lens;member;Mission;Modeling;Molecular;Mus;network models;Network-based;new therapeutic target;next generation;novel;novel therapeutic intervention;Outcome;pathogen;Pathogenicity;Pathway interactions;Play;Population;predictive marker;predictive modeling;predictive signature;Preventive Medicine;Process;SARS coronavirus;SARS-CoV-2 infection;SARS-CoV-2 variant;Scientist;Severities;Severity of illness;Symptoms;Systems Biology;Technology;therapeutic target;three dimensional structure;Tissues;Tropism;Vaccination;Validation;Variant;Viral;Virus;virus host interaction;Virus Replication;virus tropism

PROJECT_TITLE: Core C - Modeling Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The Building Research Aspirations In Neurology (BRAIN) program provides an intensive, hands -on research experience to support the development of future clinician scientists in neurology. Undergraduate students from populations typically underrepresented in clinical neurology are trained in research methods to conduct studies to better understand, diagnose, and treat neurologic conditions. The students will participate in professional development and educational activities to establish a solid foundation to enable them to transition to a graduate-level program in clinical neurology.

PI_NAMEs: MINEN, MIA  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Acute;Address;American;aspirate;Biological Sciences;career;Career Choice;career development;Clinical;Clinical Research;college;Communication;community building;cost;Development;Diagnosis;Disabling;Disparity;Education;Education Projects;Educational Activities;Ensure;Epidemiology;Ethnic Origin;Ethnic Population;experience;Faculty;falls;follow-up;Foundations;Funding;Future;Generations;Goals;Growth;hands on research;Health;health care disparity;Health Services Accessibility;higher education;improved;Individual;Institution;interest;Knowledge;Laboratories;leadership development;Learning;Life;Manuscripts;Medical Research;medical schools;medical specialties;Medical Students;Medicine;meetings;Mentors;Mentorship;Minority Groups;Modeling;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurologic;Neurologist;Neurology;Neurosciences;Neurosciences Research;Outcome;Participant;patient oriented;Patient-Focused Outcomes;Peer Review;Performance;Population;Preparation;prevent;Program Development;programs;Publications;Publishing;Race;racial population;Readiness;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Training;Residencies;retention rate;Schedule;Scientist;Severity of illness;social;socioeconomic diversity;Solid;Students;summer program;symposium;Talents;Time;Time Management;timeline;Training;Training and Education;translational neuroscience;undergraduate student;Underrepresented Minority;underrepresented minority student;Underserved Population;virtual;Work;Writing


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Emphysema;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative: Chronic obstructive pulmonary disease (COPD) is diagnosed by spirometry but significant disagreement exists between spirometric diagnosis and presence of emphysema on computed tomography (CT) due to possibility that a substantial portion of the lung has abnormal mechanics. Using image registration to match inspiratory and expiratory scans point-to-point, we will identify Silent Zones of the lung that appear normal using density thresholds but have abnormal mechanics. The proposed project will use a combination of quantitative imaging and deep learning tools to establish a novel CT biomarker that will enhance diagnosis of clinically significant COPD and also identify individuals at high risk for disease progression.

PI_NAMEs: BODDULURI, SANDEEP  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Acceleration;Activities of Daily Living;Affect;Agreement;airway obstruction;Anatomy;Area;Biological Markers;Biomechanics;Biometry;career;career development;Cause of Death;Chronic Obstructive Pulmonary Disease;Classification;Clinical;clinical diagnosis;clinical practice;clinically significant;cohort;Complex;Computer Vision Systems;cone-beam computed tomography;convolutional neural network;Data;Data Set;deep learning;deep neural network;density;Development;Development Plans;Diagnosis;diagnosis standard;Disease Progression;Dyspnea;early detection biomarkers;Early Diagnosis;Elasticity;Enrollment;follow-up;former smoker;genetic epidemiology;Goals;Health Care Costs;high risk;Image;image registration;imaging biomarker;Impairment;improved;Individual;inflammatory lung disease;K-Series Research Career Programs;Label;Lung;lung basal segment;Lung Diseases;lung imaging;Machine Learning;machine learning method;Measures;Mechanics;Medical;Medical Imaging;Mentorship;mortality;Nature;neural network architecture;Neural Network Simulation;novel;Outcome;parallel computer;Persons;Physiology;Process;prognostic;prognostic value;Pulmonary Emphysema;pulmonary function;pulmonary function decline;Pulmonary Function Test/Forced Expiratory Volume 1;Quality of life;quantitative imaging;Questionnaires;Research;Research Proposals;Respiration;respiratory;respiratory health;respiratory morbidity;Respiratory Signs and Symptoms;Scanning;Semantics;Severities;skills;small airways disease;Smoker;Spirometry;statistics;Stress;Structure of parenchyma of lung;Testing;Tissue Expansion;Tissues;tool;Training;Translational Research;United States;Visit;Walking;X-Ray Computed Tomography

PROJECT_TITLE: Silent Zones of Lung Disease in COPD

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy;Microbiome

ORG_DEPT: PEDIATRICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Cancer progression and metastasis account for the majority of cancer- related deaths, yet how cancer overcomes the immune system to metastasize is only beginning to be understood. Moreover, we have yet to determine how interactions between microbes residing in our gut and our immune systems modulate cancer metastasis. Since antibodies produced by B cells interact with microbial products and are critical for fighting cancer we propose to combine the use of a novel animal model lacking a major class of immunoglobulins, developed by Dr. Zeng, with fecal matter transplantation in a state of the art germ-free animal facility, to: 1) dissect the role of antibodies in cancer progression and 2) determine how the gut microbiome may modulate antibody-mediated anti-tumor responses in well-characterized mouse models of cancer.

PI_NAMEs: MATEI, IRINA ;ZENG, MELODY Y (contact);ZHOU, XI KATHY

PROGRAM_OFFICER_NAME: KIM, YOUNG S

PROJECT_TERMS: Acceleration;adaptive immune response;Affect;Affinity;animal facility;Animal Model;anti-tumor immune response;Antibodies;Antitumor Response;B cell repertoire;B-Lymphocyte Subsets;B-Lymphocytes;cancer biomarkers;Cancer Control;cancer immunotherapy;Cancer Model;cancer therapy;Cell Communication;Cell Physiology;Cells;Cessation of life;Compensation;Cross Presentation;cytotoxic CD8 T cells;Data;Development;Disease;Elderly;Enhancers;fighting;fitness;Germ-Free;gut bacteria;gut microbes;gut microbiome;Humoral Immunities;Immune;Immune response;Immune system;Immunoglobulin G;Immunoglobulins;Immunologic Markers;Immunologic Surveillance;Immunologist;Immunology;immunoregulation;Immunotherapy;Impairment;improved;Infiltration;Inflammation;Interleukin-10;Investigation;Knockout Mice;Lead;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Melanoma;Memory B-Lymphocyte;Microbe;microbial;microbial products;Micrometastasis;Modeling;mouse model;multidisciplinary;Mus;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;novel;pathogen;Pathway interactions;Patients;Phenotype;Play;Population;Predisposition;prevent;Primary Neoplasm;Principal Investigator;Production;Prognosis;recruit;response;Risk;Role;Sarcoma;Science;Shapes;Specificity;Therapeutic;Transplantation;Treatment outcome;tumor;Tumor Antigens;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor stage;Tumor Suppression;tumor-immune system interactions;tumorigenic;uptake

PROJECT_TITLE: Dissecting the interplay between immunoglobulin G and the gut microbiome in cancer progression and metastasis

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Dental, Oral, and Craniofacial Disease;Neurosciences;Pain Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAN ANTONIO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative/Public Health Relevance Statement Current management of endodontic pain (NSAIDs/APAP and opioids) is associated with adverse side effects. Our study proposes to study a previously unknown mechanism of stem cell-induced analgesia via macrophage migratory inhibitory factor, in a mouse model of dental pain.

PI_NAMEs: RUPAREL, NIKITA  (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Absence of pain sensation;Acetaminophen;Afferent Neurons;AMD3100;Animals;antagonist;Antibodies;antinociception;Apical;Attenuated;attenuation;Behavior;Behavioral Assay;Capsaicin;Cell Line;Coculture Techniques;comparison control;conditioned place preference;CRISPR/Cas technology;CXCR4 gene;CXCR4 Receptors;Data;Degenerative polyarthritis;Disease Progression;Effectiveness;Electrophysiology (science);Endodontics;Evaluation;experience;Female;Fostering;Goals;Home;Homing;Human;human stem cells;Image;In Vitro;in vitro activity;in vivo;Infection;Injections;knock-down;Knock-out;Knowledge;Ligands;Macrophage;male;mechanical allodynia;Mechanics;Mediating;Medical;Mesenchymal Stem Cells;microbial;Migraine;Modeling;mouse model;Mus;Neurons;Nociception;non-opioid analgesic;Non-Steroidal Anti-Inflammatory Agents;novel;Opioid;orofacial;Orofacial Pain;Pain;pain behavior;painful neuropathy;Pathway interactions;Patients;Periapical Granuloma;Periapical Periodontitis;Peripheral;peripheral pain;Persistent pain;Pertussis Toxin;programs;Proteins;public health relevance;receptor;Regulation;Research;Rodent Model;Role;Route;secondary analysis;Sex Differences;side effect;Signal Pathway;Signal Transduction;Site;small hairpin RNA;small molecule;stem cells;System;Testing;Therapeutic;Tissues;tongue papilla;Tooth structure;Toothache;Trigeminal System;Up-Regulation;voltage

PROJECT_TITLE: Evaluation of the Role of Macrophage Migratory Inhibitory Factor (MIF) in mediating Stem Cell Analgesia in a Model of Orofacial Pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Data Science;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Obesity;Precision Medicine;Prevention;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Ablation;Address;animal data;Animal Model;Animals;bench to bedside;Biological;Biological Markers;biomarker identification;Cells;Characteristics;Clinical;Clinical Data;cohort;Cohort Studies;Collection;Communities;comorbidity;Coronavirus Infections;COVID-19 pandemic;COVID-19 patient;Data;Data Collection;data integration;Data Set;Dimensions;Disease;Disease Outcome;disorder risk;Early identification;Economics;Elderly;emerging virus;Experimental Animal Model;Generations;Genes;Genetic;genetic signature;Goals;Hamsters;Healthcare Systems;Human;human data;Hypertension;Immune;Immune response;Immunity;Immunization;immunological status;In Vitro;in vivo;Individual;Infection;Integration Host Factors;interest;Intervention;Knockout Mice;lens;Licensing;Mediating;medical schools;Metadata;Modeling;molecular marker;Molecular Profiling;Morbidity - disease rate;Multiomic Data;multiple omics;Mus;Mutation;Nature;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;pandemic disease;Pathology;Patients;Persons;pharmacologic;Population;Predisposition;prospective;Recombinants;recruit;Research;Retrospective cohort;RNA vaccine;Sampling;SARS coronavirus;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 variant;severe COVID-19;Severity of illness;sex;Specimen;Stress;Study models;System;Systems Biology;Testing;Therapeutic Intervention;Training;transmission process;Vaccinated;Vaccination;Validation;Variant;Viral;Viral Vector;Virus

PROJECT_TITLE: Project 1 - A systems biology approach to identify early networks and signatures associated with mild and severe SARS-CoV-2 infections in vivo


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_DEPT: GENETICS

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: The mechanosensitive channels MscS and MscL are ubiquitously expressed in bacteria, including in most pathogenic strains. While they allow bacteria to survive extreme osmotic changes in the environment, their inappropriate opening can be lethal for the bacteria, making these channels intriguing targets for developing novel antibiotics. MscL is also being explored for nanotechnological applications, such as in the delivery of active molecules to inflamed or cancerous tissues.

PI_NAMEs: WALZ, THOMAS  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Adopted;Affect;Anacystisnidulans;Antibiotics;Bacteria;beta-Cyclodextrins;Binding;Biological Process;blood pressure regulation;Cancerous;Carbon;Cells;Chimeric Proteins;copolymer;Cryoelectron Microscopy;Cyclic AMP;Cyclic Nucleotides;cyclic-nucleotide gated ion channels;Cytolysis;desensitization;Diameter;Drug Delivery Systems;Electrophysiology (science);Environment;Equilibrium;Escherichia coli;Eukaryota;Exposure to;falls;Family;follow-up;Gadolinium;Hearing;Human;imaging agent;Incubated;insight;Ions;Length;Life;Ligand Binding;Lipids;Lysophospholipids;maleic acid;Maps;mechanical force;mechanical stimulus;member;Membrane;Molecular;Molecular Conformation;molecular dynamics;mutant;nano;nanodisk;Nanotechnology;novel;novel antibiotic class;Osmosis;paralogous gene;particle;patch clamp;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;Play;pressure;Probability;Prokaryotic Cells;Proteins;Reaction;reconstitution;Resolution;response;Role;Sensory Process;Stress;Structure;Styrenes;Synechocystis;Testing;Tissues;Touch sensation;Visualization;Work

PROJECT_TITLE: Elucidating the gating mechanisms of bacterial mechanosensitive channels

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Nanotechnology;Neurosciences;Rare Diseases;Usher Syndrome

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE Mutations in USH2A, which are responsible for ~85% of all USH2 cases, lead to severe auditory defects and late onset retinitis pigmentosa (RP), and in some cases autosomal recessive non-syndromic RP. Developing an effective treatment for USH2A has been challenging due to its very large coding sequence and the presence of isoforms with functions that are not fully understood. We aim to extend the benefits of our proven non-viral gene therapy platform consisting of nanoparticles, nanospheres, and sulfotyrosine to enhance delivery, protection, controlled release, and distribution of intravitreally delivered Ush2a gene to rescue vision loss associated with USH2A.

PI_NAMEs: NAASH, MUNA I. (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Affect;Age;Ankle;Auditory;Auditory system;autosome;Basement membrane;Binding;Biochemical;Blindness;Cells;Cilia;Cochlea;Code;Complementary DNA;Complex;controlled release;deafness;Defect;delivery vehicle;Development;Disease;disease model;DNA;DNA delivery;effective therapy;Electroretinography;Elements;Encapsulated;Engineering;extracellular;Eye diseases;follow-up;Formulation;Foundations;fundus imaging;Gene Delivery;Gene Expression;gene therapy;Genes;Genomics;Goals;GRK1 gene;Hair Cells;hearing impairment;Hemagglutinin;Hereditary Disease;Histology;Human;Hyaluronic Acid;Immunohistochemistry;in vitro testing;Injections;Inner Limiting Membrane;innovation;intravitreal injection;Investigation;Knock-in;Knock-in Mouse;Knowledge;Lead;Learning;Light;Link;link protein;Measures;Membrane;Modeling;Molecular Biology;Morphology;mouse model;Mus;mutant;Mutation;N-terminal;nanoformulation;nanoparticle;Nanosphere;non-viral gene delivery;non-viral gene therapy;nonhuman primate;Ocular Physiology;Outcome;Outcome Study;Papio;Pattern;Penetration;Phenotype;Photoreceptors;Play;Process;promoter;Protein Isoforms;protein transport;Proteins;Quantitative Reverse Transcriptase PCR;rational design;Retina;Retinal Diseases;Retinitis Pigmentosa;Role;Route;Safety;Saline;Severities;Signal Transduction;small molecule;Solid;Structure;Symptoms;Testing;therapeutic development;therapeutic DNA;therapeutic gene;therapy design;Toxic effect;Transcript;transduction efficiency;Transfection;Transmembrane Domain;Treatment Efficacy;tyrosine O-sulfate;USH2A gene;Usher Proteins;Usher Syndrome;Usher Syndrome Type 2A;vector;Vision;Visual;Visual Acuity;Visual System;Western Blotting

PROJECT_TITLE: Non-viral gene delivery platforms for the treatment of Usher Syndrome Type 2A.

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

PI_NAMEs: MCCOOL, BRIAN A (contact)

PROJECT_TERMS: Adolescent;Adult;Affect;Age;age related;aged;Agonist;Alcohol abuse;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol research;alcohol reward;alcohol use disorder;Alcoholism;Amygdaloid structure;Anatomy;Animals;anxiety-like behavior;Behavior;Behavior Control;behavior measurement;Behavioral;Behavioral Mechanisms;behavioral outcome;Brain;Brain region;Cells;Characteristics;Chronic;Classification;Cognitive;Data;Dependence;designer receptors exclusively activated by designer drugs;Development;differential expression;disability;Electrophysiology (science);Emotional;Ethanol;experimental study;Exposure to;gamma-Aminobutyric Acid;Glutamates;Goals;Heavy Drinking;Human;Individual;innovation;Interruption;knock-down;Lateral;Messenger RNA;Metabolic;Molecular;neurobiological mechanism;Neurobiology;Neurons;neurophysiology;neurotransmission;Nucleus Accumbens;Outcome;overexpression;Pathway interactions;periadolescent;Persons;Phenotype;Population;Process;Property;protein protein interaction;Proteins;Publishing;Rattus;receptor;Research;response;Rewards;Ribosomal Proteins;Risk;Rodent;Sensory;sex;Signal Transduction;Structure;Structure of terminal stria nuclei of preoptic region;Synapses;Testing;therapeutic target;therapy design;transcriptome sequencing;transition to adulthood;Translating;underage drinking;vulnerable adolescent;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Project 3: Adolescent vulnerability to chronic ethanol: neurophysiological, molecular, and behavioral mechanisms of adult AUD


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative (Public Health Relevance) The membranes of mammalian cells have complex compositions that are required for their unique structure and vast array of functions. The research in our laboratory is focused on defining the diversity of mammalian membrane compositions and how those lipids are organized to facilitate cellular physiology. The insights from work are expected to inform therapeutic strategies for diseases associated with membrane dysfunction, including cardiovascular disease and cancer.

PI_NAMEs: LEVENTAL, ILYA  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Address;Affinity;biophysical analysis;Biophysics;Cardiovascular Diseases;Cell membrane;Cell Physiology;Cells;Code;Complex;computer framework;Coupled;design;dietary;Dietary Fatty Acid;Disease;Functional disorder;Goals;Homeostasis;immune activation;insight;Laboratories;Lateral;Life;lipidome;lipidomics;Lipids;Malignant Neoplasms;Mammalian Cell;Membrane;Membrane Fluidity;Membrane Protein Traffic;Methodology;Microscopy;novel therapeutic intervention;Phenotype;physical property;Predisposition;Property;Proteins;public health relevance;Research;Resolution;response;Role;Structure;Therapeutic;treatment strategy;Trees;Work

PROJECT_TITLE: The functional organization of mammalian membranes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-G(55)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Narrative The misfolding and aberrant liquid-liquid phase separation of several different RNA-binding proteins is implicated in Alzheimer’s disease and several related dementias such as frontotemporal dementia (FTD). Matrin-3 (MATR3) was recently implicated in FTD and has several key similarities and differences as compared to other proteins known to drive dementia. Here, we will delineate key properties of MATR3 with respect to liquid-liquid phase separation, RNA binding, and interactions with other FTD-associated proteins in order to better understand how to develop new therapeutics for dementia.

PI_NAMEs: JACKREL, MEREDITH E. (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: ALS patients;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Automobile Driving;Binding;Biochemical;biophysical techniques;C9ORF72;Cell Nucleus;Cells;Dementia;Development;Dipeptides;Disease;familial amyotrophic lateral sclerosis;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;interest;Knowledge;Length;link protein;Liquid substance;Mammalian Cell;matrin 3;Molecular;Molecular Chaperones;Mutation;Neurodegenerative Disorders;Neurons;novel therapeutics;Pathogenesis;Pathologic;Pathology;Patients;Phase;Physiological;preservation;prion-like;Process;Property;protein misfolding;protein TDP-43;Proteins;proteostasis;Quality Control;reconstitution;Regulation;Reporting;response;RNA;RNA Binding;RNA metabolism;RNA Recognition Motif;RNA-Binding Proteins;Role;skills;sporadic amyotrophic lateral sclerosis;synergism;System;Techniques;Testing;Therapeutic;therapeutic development;therapeutic RNA;Toxic effect;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Delineating the role of Matrin-3 in driving aberrant liquid-liquid phase separation that underpins ALS/FTD


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Lung;Neurosciences;Opioids

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Opioid use is associated with life-threatening depression of breathing and aspiration by actions in the central nervous system. Further, opioids are often prescribed to older adults who are particularly at risk of sleep disordered breathing and pneumonia due to impaired control of respiratory muscles by the brain.

PI_NAMEs: BOLSER, DONALD C (contact);MORRIS, KENDALL FRANCIS

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: addiction;Address;Anatomy;Animal Model;Area;aspirate;Behavior;Behavioral;Brain;Brain Stem;Breathing;Cell Nucleus;Cells;Central Nervous System;Cessation of life;Chemoreceptors;Coughing;Data;Development;Dose;drug discovery;Elements;Exhibits;Feedback;Goals;Impairment;Knowledge;Life;Mediating;Modeling;models and simulation;Motor;Motor Neurons;Motor output;neural network;neuronal circuitry;Neurons;novel therapeutic intervention;older adult;Opioid;opioid mortality;opioid overdose;opioid use;Outcome;Pathway interactions;Pattern;Pharmaceutical Preparations;Phase;Pneumonia;Pontine structure;Population;Positioning Attribute;preBotzinger complex;predictive modeling;prescription opioid;presynaptic;Probability;programs;protective behavior;Regulation;Research;respiratory;Respiratory Muscles;Respiratory System;Risk;Role;Sleep Apnea Syndromes;success;System;Technology;Ventilatory Depression;Work

PROJECT_TITLE: Influence of Opioids on the Brainstem Respiratory Network

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: GARCIA-SASTRE, ADOLFO  (contact)

PROJECT_TERMS: 2019-nCoV;A549;Affect;Anti-viral Therapy;Appearance;ATAC-seq;Biochemical;Biological;Biological Models;Candidate Disease Gene;candidate marker;Cell Line;cell type;Cells;Cessation of life;Chemicals;ChIP-seq;Chiroptera;Clinical;clinical biomarkers;Clinical Data;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Coronavirus;COVID-19;COVID-19 pandemic;COVID-19 severity;CRISPR/Cas technology;cross-species transmission;cytokine;Data;data integration;data modeling;design;Development;Disease;Disease Outcome;Disease Progression;Epigenetic Process;epigenomics;Epithelial Cells;experimental study;Generations;Genes;Genetic;Genetic Transcription;Hi-C;Human;Immune;Immune response;improved;in silico;in vivo;in vivo evaluation;in vivo Model;induced pluripotent stem cell;Infection;Inflammatory;insight;knockout gene;lens;Life Cycle Stages;Link;loss of function;Lung;machine learning algorithm;Maps;Measurement;Mediating;Modeling;Molecular;Molecular Profiling;Mus;mutant;Mutation;Network-based;novel;novel therapeutics;Outcome;pandemic disease;pathogen;Pathogenicity;Pathway interactions;pneumocyte;post SARS-CoV-2 infection;Post-Translational Protein Processing;predictive marker;predictive modeling;Production;protein expression;Proteins;proteomic signature;Proteomics;receptor;response;Role;Sampling;Sarbecovirus;SARS coronavirus;SARS-CoV-2 variant;Severity of illness;single-cell RNA sequencing;small molecule;Systems Biology;Tertiary Protein Structure;Testing;therapeutic target;transcriptome sequencing;transcriptomics;transmission process;Tropism;Validation;Variant;Viral;Viral Proteins;Virus;Virus Diseases;virus host interaction;Virus Replication;Zoonoses

PROJECT_TITLE: Project 2 - Ex Vivo Analysis of Coronavirus Tropism, Adaptation, Replication, and Host Response


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE CHAMACOS is a 20+ year old longitudinal cohort study of Latino mothers (1st generation) and children (2nd generation) from a California farmworker community who have been followed since before birth through young adulthood. As the 2nd generation approaches prime reproductive age, we propose to enrich the cohort by enrolling 3rd generation children and incorporating neighborhood-level data on social determinants of health. This grant would also support the CHAMACOS infrastructure to promote data sharing and scientific engagement with Latino students, faculty, and clinicians to increase work force diversity.

PI_NAMEs: HARLEY, KIM G. (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 1 year old;18 year old;20 year old;Address;Adult;Adult Children;Age;agricultural community;Agriculture;Allergens;Applications Grants;Area;Behavioral;biobank;Biological;Biological Markers;Biomedical Research;Birth;Blood;California;cardiometabolism;Chemicals;Child;Child Health;citizen science;Clinical;cohort;Cohort Studies;Collaborations;Collection;college;Communities;community engagement;Community Outreach;Data;data access;Data Collection;data de-identification;data management;data repository;data sharing;Deposition;Development;Dust;early life exposure;Ecosystem;Education;emerging adult;Enrollment;Ensure;environmental chemical;environmental enrichment for laboratory animals;Environmental Epidemiology;Environmental Exposure;Environmental Health;Environmental Impact;epigenetic aging;Epigenetic Process;Exposure to;Faculty;FAIR principles;farm worker;Federally Qualified Health Center;Flame Retardants;Focus Groups;Fostering;Funding;Future;Generations;Genetic study;graduate student;Grant;Growth;Hair;Health;Health Food;high school;High School Student;higher education;Hispanic-serving Institution;Human;Human Milk;Immigrant;improved;Individual;Infrastructure;insight;junior high school;Knowledge;Latina Population;Latino;Leadership;Link;Longitudinal cohort study;Low income;Measures;Mental Health;Mentors;Middle School Student;Migrant;Mothers;nasal swab;Neighborhoods;neurodevelopment;novel;Obesity;open-access repositories;Outcome;Parents;Participant;Pesticides;Phase;phthalates;Population;Pregnancy;preservation;Protocols documentation;psychosocial;pubertal timing;Public Health;pulmonary function;R24;Racial Segregation;repaired;reproductive;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Retirement;Running;Salinas Valley;Saliva;Sampling;science teacher;Scientific Advances and Accomplishments;social;social determinants;social health determinants;Stress;Structural Racism;Students;Study of Latinos;success;Tooth structure;undergraduate student;Underserved Population;Unemployment;United States National Institutes of Health;university student;Urine;Visit;web portal;Woman;Work;young adult

PROJECT_TITLE: Fostering Scientific and Workforce Diversity by Maintaining and Enriching the CHAMACOS Birth Cohort


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Gene Therapy;Genetics;Muscular Dystrophy;Myotonic Dystrophy;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_DEPT: OTHER BASIC SCIENCES

PHR: PROJECT NARRATIVE Short tandem repeat expansions in transcribed regions of the genome are the cause of numerous neuromuscular and neurological diseases for which no known cures exist. Here we develop innovative RNA-based therapeutic platforms to target these toxic gain-of-function transcripts for degradation, and establish novel human cellular and mouse disease models to evaluate safety and efficacy of our candidate therapeutic systems. As proof-of- principle, we focus on myotonic dystrophy type 1 with the aim to address both the muscle and neurocognitive deficits of the disease.

PI_NAMEs: SWANSON, MAURICE SCOTT;YEO, EUGENE WEI-MING (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: 3' Untranslated Regions;Acceleration;adaptive immune response;Address;adeno-associated viral vector;adenovirus mediated delivery;Adult;Alleles;Antisense Oligonucleotides;Attenuated;BCAR1 gene;Binding;Brain;brain abnormalities;C9ORF72;Cell model;Cells;CUG repeat;Data;design;Development;Disease;disease model;disorder control;effective therapy;Engineering;Evaluation;Event;Exons;flexibility;frontotemporal lobar dementia amyotrophic lateral sclerosis;gain of function;Gene Expression;gene therapy;Genetic Transcription;Genome;Germ Lines;Health;Human;Human Genome;human stem cells;humanized mouse;Huntington Disease;Immunity;in utero;in vivo;Individual;innovation;insight;knock-down;Knock-in;Knock-in Mouse;lead candidate;Link;Mediating;Microsatellite Repeats;Modality;Modeling;Molecular;mouse model;Mus;Muscle;Muscle Development;Muscular Dystrophies;mutant;Mutation;Myoblasts;Myocardium;Myotonic dystrophy type 1;Nervous System Disorder;Neurocognitive Deficit;Neurodegenerative Disorders;Neuromuscular Diseases;novel;novel therapeutic intervention;Organoids;Pathology;Polyadenylation;Predisposition;Proteins;Recombinants;Reporter;Risk;RNA;RNA delivery;RNA Processing;RNA Splicing;RNA-targeting therapy;Safety;safety testing;Short Tandem Repeat;Signal Transduction;Skeletal Muscle;small hairpin RNA;Small Interfering RNA;Small Nuclear RNA;societal costs;Specificity;Spinocerebellar Ataxias;Spliceosomes;System;Tandem Repeat Sequences;Testing;Therapeutic;Therapeutic Agents;therapeutic candidate;therapeutic RNA;therapy development;Time;Tissues;Toxic effect;Transcript;U1 small nuclear RNA;Work

PROJECT_TITLE: Therapeutic strategies for microsatellite expansion diseases using RNA targeting

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Post-Traumatic Stress Disorder (PTSD);Sleep Research;Social Determinants of Health;Substance Misuse

PI_NAMEs: WEINER, JEFFREY L. (contact)

PROJECT_TERMS: Address;Adolescent;Alcohol consumption;alcohol research;alcohol risk;alcohol use disorder;Amygdaloid structure;Animal Model;Animals;Anxiety;anxiety-like behavior;Architecture;Behavior;Behavioral;behavioral phenotyping;behavioral study;Clinical;Corpus striatum structure;Development;Diagnosis;Disease;Dopamine;drinking;early childhood;efficacy evaluation;Electroencephalography;Electrophysiology (science);Epidemiology;Ethanol;Extinction;Female;Fiber;Fright;Glutamates;Goals;Hippocampus;human subject;in vivo;Individual;innovation;kappa opioid receptors;Knowledge;Life;Link;maladaptive behavior;male;Measures;Mediating;Mental Depression;Modeling;Motivation;multidisciplinary;negative affect;neural;neuroadaptation;Neurobiology;neurochemistry;neuromechanism;neuropsychiatric disorder;Nucleus Accumbens;Opioid Antagonist;optogenetics;Pathway interactions;pharmacologic;Phenotype;Photometry;Play;Post-Traumatic Stress Disorders;Procedures;Publishing;Rattus;receptor function;resilience;Risk Factors;Rodent;Rodent Model;Role;Self Administration;sex;Sleep;Sleep Architecture;Sleep disturbances;Social isolation;Stress;stressor;symptomatology;Symptoms;Synapses;Synaptic Transmission;Testing;Therapeutic Intervention;translational study;Vulnerable Populations;wireless;women subjects

PROJECT_TITLE: Project 4: Convergent behavioral and neurobiological adaptations promoted by rodent models of vulnerability to alcohol use disorder and post-traumatic stress disorder


NIH_SPENDING_CATS: Asthma;Clinical Research;Lung;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD);Pediatric

PHR: Project Narrative A key goal of this project is to reveal the role of the blood microbiome in asthma pathogenesis. The proposed research is relevant to public health because it enables us to systematically identify candidate causal microbial strains that can potentially prevent asthma. Thus, the proposed research is relevant to NIH’s mission towards developing fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance human health and reduce illness.

PI_NAMEs: SUN, ZHENG  (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Advisory Committees;Affect;Algorithms;antenatal;Archaea;Area;Asthma;asthma model;Bacteria;Behavior;Benchmarking;Bioinformatics;Biological Markers;Biology;Biomass;Blood;Blood specimen;candidate identification;Cessation of life;Child;Childhood;Childhood Asthma;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;Classification;Clinical;clinical translation;cohort;Committee Members;computational pipelines;computing resources;Controlled Clinical Trials;cost effective;cost efficient;Data;Data Analyses;deep learning;Development;Diagnosis;diagnostic accuracy;DNA;Double-Blind Method;dysbiosis;Early Diagnosis;Educational workshop;Environment;Equation;Etiology;Feedback;Functional disorder;fungus;genetic information;Genetic Variation;Goals;Graph;graph neural network;gut-lung axis;Health;High-Throughput Nucleotide Sequencing;Hospitals;Human;improved;Incidence;interest;Knowledge;Link;Longitudinal cohort;Longitudinal Studies;Lung;Lung Diseases;Mediation;medical schools;Mendelian randomization;Mentors;metagenomic sequencing;Metagenomics;Methods;Microbe;microbial;microbial composition;Microbial Taxonomy;microbiome;microbiome research;microorganism;Mission;Modeling;Molecular;Molecular Biology;Nature;novel;Organism;Outcome;Pathogenesis;Patients;Persons;Phase;Placebo Control;Play;precision medicine;predictive modeling;Pregnant Women;prevent;Prospective Studies;Public Health;Questionnaires;Randomized;Reporting;Research;Research Personnel;Resolution;respiratory;Risk;Role;Sampling;Severities;Site;skills;Statistical Models;Study models;Taxonomy;Teaching Hospitals;Techniques;Testing;Time;Training;Training Programs;United States National Institutes of Health;Validation;Vitamin D;Woman;Work

PROJECT_TITLE: Revealing the role of blood microbiome in childhood asthma

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(OA)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Prevention;Serious Mental Illness;Social Determinants of Health;Suicide

ORG_CITY: DUBLIN

ORG_COUNTRY: IRELAND

ORG_FIPS: EI

ORG_NAME: TRINITY COLLEGE DUBLIN

PHR: PROJECT NARRATIVE Social disconnection and suicidal behaviours in later life are important and related public health concerns. This study leverages longitudinal data from a large, nationally representative cohort of older adults to examine the processes that link these two phenomena. Study results will identify risk and protective factors to inform both community and clinical interventions.

PI_NAMEs: WARD, MARK  (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Address;Adult;Age;aged;Aging;Alcohol consumption;Anxiety;Behavioral;Biological Markers;Biology of Aging;cardiometabolism;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;Clinic;Clinical;Clinical Markers;cohort;Collaborations;Communities;community intervention;community setting;Complex;Data;Data Analytics;Early identification;Economics;Europe;Exhibits;experience;Feeling hopeless;Feeling suicidal;field study;Future;geriatric depression;Goals;Growth;Health;health assessment;health care settings;health definition;Heart Rate;high risk;Hydrocortisone;ideation;Immune;immune function;improved;Impulsivity;Individual;inflammatory marker;International;Intervention;Ireland;Knowledge;late life;Link;Loneliness;Longitudinal Studies;Mental Depression;Mental Health;Modeling;multidisciplinary;National Institute of Mental Health;Nature;Neurosecretory Systems;older adult;Parasympathetic Nervous System;Participant;Pathway interactions;Perception;Persons;Physical activity;physical conditioning;Physiological;Play;prevent;Process;Prospective cohort;Prospective Studies;Prospective, cohort study;protective factors;psychologic;Public Health;Questionnaires;Reporting;Research;Research Domain Criteria;Research Personnel;response;Risk;Risk Factors;Role;Sleep;Smoking;social;Social Environment;social integration;Social isolation;social relationships;sociodemographics;sociologist;Stress;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide rate;Surveys;System;Techniques;Testing;theories;Thinking;Time;Training;Uranium;Woman

PROJECT_TITLE: Pathways from social disconnection to suicidal ideation in later life


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pain Research

ORG_DEPT: NEUROSURGERY

PHR: PROJECT NARRATIVE The severe toll that chronic pain takes on society, made especially clear by the recent opioid epidemic, underscores the need for innovative treatments, particularly for those people with intractable pain who have failed conventional medical and surgical management. Intracranial electrodes implanted for the purpose of epilepsy monitoring provide a rare opportunity to define neurophysiological signatures of pain representations in the human brain and modulate neural circuit activity to attenuate the pain state. Information gained from targeted, high-resolution access to human pain networks can be directly translated to improve existing therapies, including the implantation of deep-brain stimulating electrodes for the treatment of chronic pain.

PI_NAMEs: BEN-HAIM, SHARONA  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Adult;Affective;Amygdaloid structure;Anatomy;animal pain;Animals;Anterior;archived data;Attenuated;Award;Biological Markers;Biometry;Brain;Brain region;career;career development;Cerebrum;Chronic;chronic pain;chronic pain management;chronic pain patient;chronic painful condition;cingulate gyrus;Clinical;clinical pain;Clinical Research;Clinical Trials Design;Cognitive;cohort;Complex;Conventional Surgery;Coupling;Data;Deep Brain Stimulation;design;Development;Development Plans;Diagnosis;Dimensions;Double-Blind Method;effective therapy;Electrodes;Electroencephalography;Electrophysiology (science);Emotional;Epidemiologic Methods;Epilepsy;experience;FDA approved;Foundations;Frequencies;Functional Imaging;Future;Goals;Human;Hybrids;Implant;implantation;Implanted Electrodes;improved;innovation;Insula of Reil;Intervention;Intractable Pain;Link;Literature;Measures;Medical;Mentors;Methods;Modality;Modeling;Monitor;neural;neural circuit;Neurobiology;neuromechanism;neurophysiology;neuroregulation;neurosurgery;Nociception;novel;Operative Surgical Procedures;Opioid;opioid epidemic;Pain;Pain management;Pain Measurement;pain perception;pain processing;pain reduction;pain relief;Pathway interactions;Patient Self-Report;patient subsets;Patients;Persons;Phase;Physiology;Postoperative Pain;predictive marker;Prefrontal Cortex;pressure;Prosencephalon;prospective;Psychophysics;Questionnaire Designs;Research;Resolution;Sampling;Sensory;Signal Transduction;Site;Societies;Specific qualifier value;Specificity;Surgical Management;Techniques;Technology;Testing;Therapeutic;Training;Translating;United States;Variant;Work

PROJECT_TITLE: Defining the forebrain neurophysiological representation of pain

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Clinical Research;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences

PHR: Narrative Multiple sclerosis (MS) is a debilitating demyelinating disease of the central nervous system (CNS) that affects approximately 2.5 million people worldwide. There remains an unmet clinical need for new therapeutic strategies that can restore and sustain long-term immune tolerance in MS patients. The current proposal is aimed at understanding PD1 signaling in MS patients, a major pathway implicated in peripheral immune tolerance, and leveraging these insights to maximize the efficacy of PD1 agonist monotherapies along with low-dose IL-2 combination therapies in clinically relevant MS models. The successful completion of this clinically-oriented proposal has the potential to impact treatment for MS, as well as other inflammatory and autoimmune diseases.

PI_NAMEs: GOPAL, MURUGAIYAN  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Address;Affect;Agonist;Animal Model;Anti-Inflammatory Agents;Autoimmune Diseases;Autoimmunity;autoreactive T cell;Biological Models;Calibration;CD4 Positive T Lymphocytes;cell type;Cells;Central Nervous System;central nervous system demyelinating disorder;Chimeric Proteins;Clinical;clinically relevant;clinically significant;CNS autoimmunity;Combined Modality Therapy;Complement;cytokine;Dendritic Cells;Development;Disease;Dose;effector T cell;enhancing factor;Experimental Autoimmune Encephalomyelitis;Exploratory/Developmental Grant;Goals;Helper-Inducer T-Lymphocyte;high dimensionality;high reward;high risk;Homeostasis;Human;IL2RA gene;Immune;Immune response;Immune Tolerance;Immunoglobulins;immunoregulation;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;insight;interest;Interleukin 2 Receptor;Interleukin-2;Intestines;Knock-in Mouse;Ligands;Maintenance;Mediating;Modeling;mouse model;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Mus;Myeloid Cells;novel;novel therapeutic intervention;Pathogenicity;Pathway interactions;Patients;Peripheral;Persons;Pharmaceutical Preparations;Play;prevent;programmed cell death ligand 1;programmed cell death protein 1;Regulatory T-Lymphocyte;response;restraint;Role;Signal Transduction;single-cell RNA sequencing;synergism;Systemic Lupus Erythematosus;T cell response;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Tissues;translational potential

PROJECT_TITLE: Development of novel PD1 agonist therapeutic strategies for multiple sclerosis

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Prevention

ORG_CITY: FORT WORTH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

PHR: PROJECT NARRATIVE Approximately 380 million people worldwide are suffering from diabetes mellitus, and the majority of them will encounter corneal defects at some point in their life. We propose to investigate the role of PPARα in human diabetic keratopathy and diabetic neuropathy, using novel and established in vitro and in vivo models. The proposed studies have potential to identify a new therapeutic target for prevention or treatment of diabetic corneal complications.

PI_NAMEs: KARAMICHOS, DIMITRIOS  (contact);MA, JIAN-XING

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Adult;Affect;Agonist;Animal Model;Autophagocytosis;Blindness;Cells;Child;Chronic Disease;clinical application;Clinical Research;Cornea;corneal epithelium;Cyclic GMP;Defect;Deterioration;Diabetes Mellitus;diabetic;Diabetic Neuropathies;Diabetic Retinopathy;Disease;Down-Regulation;Epidemic;Epithelial Cells;Epithelium;exosome;Extracellular Matrix;extracellular vesicles;FDA approved;Fenofibrate;Foundations;functional decline;Funding;Future;Grant;Human;Impairment;improved;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;Keratopathy;Knock-out;Knowledge;Lesion;Life;Ligands;lipid metabolism;Mediating;Metabolic;Metabolic dysfunction;metabolic profile;Metabolism;Mitochondria;mitochondrial dysfunction;Modality;Modeling;Molecular;Nerve;Nerve Degeneration;nerve supply;Neuropathy;neuroprotection;neurotrophic factor;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;overexpression;Oxidative Stress;Pathogenicity;Pathway interactions;Patients;Persons;PPAR alpha;prevent;Prevention;Production;prospective;protective effect;Public Health;Regulation;Reporting;Risk Factors;Role;Signal Transduction;Stimulator of Interferon Genes;Stress;stressor;Stromal Cells;Therapeutic Effect;Thick;transcription factor;translational potential;type I and type II diabetes;Up-Regulation;vesicular release;Visual;World Health Organization

PROJECT_TITLE: A Novel Pathogenic Pathway for Diabetic Keratopathy


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Glucagon-like peptide-1 receptor (Glp1r) agonists are used to treat diabetes and obesity due to their ability to stimulate insulin secretion and reduce food intake. The molecular mechanisms mediating these effects remain ill-defined, so the present application builds on our published and preliminary data showing that a key interaction between canonical Glp1r signaling and nutrient-sensing molecules mediate the beneficial metabolic effects of the clinically-relevant Glp1r agonist Liraglutide. Findings from this application will help us either improve current Glp1r-based drugs or assist us in identifying new molecular targets that can be used to develop newer, more effective diabetes and/or obesity therapeutics.

PI_NAMEs: AYALA, JULIO E (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Adipocytes;Adrenergic Receptor;Affect;Agonist;Appetite Depressants;Assessment tool;Binding;Blood Glucose;Body Weight;Body Weight decreased;Brain;cardiometabolism;Cell Physiology;cell type;Cells;Chinese Hamster Ovary Cell;clinical effect;clinically relevant;Closure by clamp;Complex;Coupled;Cyclic AMP-Dependent Protein Kinases;Data;design;detection of nutrient;Development;Diabetes Mellitus;Dose;drug action;Drug Side Effects;Effectiveness;energy balance;Energy Intake;Event;FRAP1 gene;Future;genetic regulatory protein;GLP-I receptor;glucagon-like peptide 1;Glucose;glucose tolerance;Glycolysis;Homeostasis;Human;Hyperglycemia;Hypothalamic structure;Hypoxia Inducible Factor;hypoxia inducible factor 1;Impairment;improved;in vivo;Individual;insulin secretion;islet;Knock-in Mouse;Knowledge;liraglutide;Measures;Mediating;Metabolic;metabolic phenotype;Molecular;Molecular Target;Morphology;mouse model;Mus;mutant;Mutation;Neurons;novel;Nutrient;Obesity;Outcome;Pancreas;Pathway interactions;personalized medicine;Pharmaceutical Preparations;Phosphorylation;Physiological;Physiology;Predisposition;Pro-Opiomelanocortin;protein activation;Proteins;Publishing;receptor;Receptor Activation;Receptor Signaling;reduced food intake;Regulation;Resistance;response;Role;sensor;Signal Transduction;temporal measurement;Test Result;Testing;Therapeutic;Therapeutic Effect;transcription factor;Treatment Efficacy;Variant;Weight

PROJECT_TITLE: Molecular mechanisms mediating metabolic benefits of glucagon-like peptide-1 receptor agonists

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Agent Orange & Dioxin;Cancer;Cancer Genomics;Endocrine Disruptors;Genetics;Human Genome;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: NARRATIVE Environmental toxicant exposures play a key role in the regulation of the epigenome, but the mechanisms remain unclear. In this proposal, we hypothesize that toxicant induced replication stress, paired with defective repair due to STAG2 loss, drives pre-malignant cell evolution and creates a permissive epigenome for transformation. This proposal is focused on understanding the molecular mechanisms by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), alone or in combination with 2,4-dichlorophenoxyacetic acid (2,4- D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) affect the replication stress response (RSR) and contribute to genetic and epigenetic heterogeneity in these tumors.

PI_NAMEs: OHM, JOYCE ELLEN (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: 2,4,5-Trichlorophenoxyacetic acid;2,4-Dichlorophenoxyacetic Acid;Adolescent;Affect;agent orange;aging related;Aneuploidy;Animal Model;Antigens;Area;biological adaptation to stress;Biological Assay;cancer type;carcinogenicity;Cell model;Cells;Characteristics;Chemicals;Child;Childhood;Chimeric Proteins;cohesin;Complex;Connective Tissue;cost;Data;Development;Diagnosis;Diagnostic;Dioxins;Disease;Disease susceptibility;DNA Repair;Endocrine Disruptors;Environmental Exposure;Epidemiology;Epigenetic Process;epigenome;epigenomics;Event;Evolution;Ewings sarcoma;EWS-FLI1 fusion protein;Exposure to;Failure;fusion gene;Fusion Protein Expression;Gene Expression;Genetic;Genetic Transcription;Genome;Genomic Instability;Genomics;Heavy Metals;Herbicides;Heterogeneity;Incidence;Lead;Life;Limb structure;Link;loss of function mutation;Malignant Neoplasms;Measurement;member;Mesenchymal Stem Cells;metaplastic cell transformation;Molecular;Mutate;Mutation;Nature;Patients;permissiveness;persistent organic pollutants;Persons;pesticide exposure;Pesticides;Play;Population;Premalignant Cell;Process;Prognosis;Regulation;repaired;replication stress;Reproducibility;Research Personnel;Role;Sarcoma;Somatic Mutation;Tetrachlorodibenzodioxin;Toxic Environmental Substances;toxicant;Toxicant exposure;tumor;tumor heterogeneity;tumorigenesis;United States National Academy of Sciences;Vietnam;virtual;War;young adult

PROJECT_TITLE: STAG2 modulates environmental toxicant exposures and epigenomic heterogeneity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(03)]


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOLOGY

ORG_NAME: DUQUESNE UNIVERSITY

ORG_STATE: PA

PHR: HSV-1 is a ubiquitous DNA virus that can cause devastating disease in immunocompromised patients and neonates, can be used as a viral vector for gene therapy approaches, and serves as an easy to manipulate model system to understand fundamental cellular and viral processes. HSV-1 utilizes multiple approaches to avoid eliciting host DNA damage responses while at the same time redirecting host proteins to viral genomes to be exploited for viral processes. We propose to use innovative approaches to investigate the role cellular proteins play in determining the outcome of infection, which will provide insight into how these proteins can be targeted for antiviral therapies.

PI_NAMEs: DEMBOWSKI, JILL ANN (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Address;Affect;Anti-viral resistance;Anti-viral Therapy;Biochemical;Biological Assay;Biological Models;Capsid;Cell Physiology;Cell Proliferation;Cells;Chromatin;Chromatin Modeling;chromatin modification;chromatin remodeling;Chromatin Remodeling Factor;Coupled;Development;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA Repair Pathway;DNA replication fork;DNA Viruses;DNA-Directed DNA Polymerase;experimental study;gene therapy;Gene Transduction Agent;Genetic;Genetic Recombination;Genetic Transcription;genome integrity;genome-wide;Goals;Herpesvirus 1;Human;Immunocompromised Host;in vivo;Infection;innovation;insight;Integration Host Factors;knock-down;Knowledge;Late Gene Transcriptions;Life Cycle Stages;Lytic;Maintenance;Mass Spectrum Analysis;Mediating;Modification;Molecular;mutant;neonate;oncolytic vector;Outcome;pathogen;Pathway interactions;Play;Population;Post-Translational Protein Processing;Process;Production;Proliferating Cell Nuclear Antigen;Protein Dynamics;protein protein interaction;Proteins;Proteomics;recombinational repair;recruit;repaired;response;Role;Simplexvirus;Testing;Time;Transcriptional Regulation;ubiquitin isopeptidase;Ubiquitination;Viral;viral DNA;Viral Genes;Viral Genome;Viral Vector;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: ROLES OF HOST FACTORS IN VIRAL REPLICATION COUPLED PROCESSES

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Networking and Information Technology R&D (NITRD)

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative The goal of this project is to democratize MRI research by developing Cloud MR, an open-source software simulation platform where researchers can test new technology and radiologists can optimize clinical protocols without operating an actual MR scanner. Through a web-based graphical user interface and cloud computing, Cloud MR will enable radiofrequency coil modeling, pulse sequence design, and the development of image reconstruction methods within the same integrated framework. Cloud MR will be a powerful tool also for training and education.

PI_NAMEs: LATTANZI, RICCARDO  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Algorithms;Anatomic Models;Asia;Biological;Brain imaging;Carbon;Clinical;Clinical Protocols;Cloud Computing;Complex;Computer software;computerized tools;Conceptions;contrast imaging;convolutional neural network;Country;Data;Data Set;Democracy;design;Development;Documentation;Electromagnetic Fields;Engineering;Environmental Impact;Excision;experimental study;flexibility;Geometry;Goals;graphical user interface;Image;image reconstruction;in vivo;Individual;innovation;Integral Equation;Internet;Intuition;Knee;Knowledge;Language;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;Methods;Modeling;models and simulation;Morphologic artifacts;neural network;new technology;novel;Online Systems;open data;open source;open source tool;Outcome;Patients;Performance;Physics;Physiologic pulse;Proliferating;prototype;radio frequency;radiologist;rational design;reconstruction;Research;Research Personnel;Research Project Grants;Running;Sampling;Seminal;Shapes;Signal Transduction;simulation;simulation environment;simulation software;skills;Software Framework;Software Tools;syntax;synthetic data;Techniques;Technology;Testing;Time;Tissues;tool;Training;Training and Education;training data;transmission process;undergraduate student;Validation;virtual;virtual reality simulation;web-based tool

PROJECT_TITLE: Cloud MR: an Open-Source Software Framework to Democratize MRI Training and Research

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Hematology;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare but lethal disease with a median survival of 1 year. The molecular role of SETD2 (the most frequently silenced gene in MEITL) and its interaction with activated oncogenes in MEITL pathogenesis is largely unknown. In this proposal, we develop novel mouse models of this disease to define the role of SETD2 in MEITL pathogenesis.

PI_NAMEs: DAVE, SANDEEP  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Address;Affect;Biological;Celiac Disease;Cell Differentiation process;Cell Physiology;cell transformation;Cells;Clinical;design;Development;Disease;disease model;DNA Damage;DNA Repair;effective therapy;Exhibits;Exons;Frequencies;Gene Silencing;Generations;Genes;Genetic;Genetic Transcription;Genomics;genotoxicity;Histone H3;histone methyltransferase;improved;innovation;Intestinal Neoplasms;Intestines;intraepithelial;Knock-out;Knockout Mice;Knowledge;Lead;Lymphocyte;Lymphoma;Lymphomagenesis;Lysine;Malignant Neoplasms;Measures;Messenger RNA;Methylation;Modeling;Modification;Molecular;mouse model;Mutate;Mutation;novel;novel therapeutic intervention;Oncogene Activation;Oncogenes;Outcome;overexpression;Pathogenesis;Pathway interactions;Patients;Phenotype;Population;premalignant;Premalignant Cell;Process;Prognosis;Recording of previous events;recruit;response;RNA Splicing;Role;single-cell RNA sequencing;Site;standard of care;STAT5B gene;T-Cell Development;T-Cell Lymphoma;T-cell receptor repertoire;T-Lymphocyte;Techniques;Testing;Therapeutic;Treatment Protocols;tumor;V(D)J Recombination;Work;γδ T cells

PROJECT_TITLE: Clinical and Genetic Origins of Monomorphic Epitheliotropic Intestinal T Cell Lymphoma

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Diabetes;Genetics;Human Genome;Nutrition;Physical Activity;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Pancreatic beta cell dysfunction is pivotal in the pathogenesis of type 2 diabetes. The proposed study will build a pathway centered on C2CD4A, a human type 2 diabetes susceptibility gene identified from genome- wide association studies in every ethnic group studied to date. Understanding the mechanism of C2cd4a- regulated insulin secretion in the pancreatic beta-cells will provide insights into diabetes therapeutics.

PI_NAMEs: KUO, TAIYI DIANA (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Ablation;Affect;Agonist;Aldolase B;Amino Acid Sequence;Beta Cell;Binding;Biological;Biological Assay;cell dedifferentiation;Cell Maturation;Cell Nucleus;Cell Physiology;Cells;ChIP-seq;Chromatin;chromosome conformation capture;Closure by clamp;Co-Immunoprecipitations;cofactor;Consensus;Coupled;Data;db/db mouse;derepression;Diabetes Mellitus;diabetes mellitus therapy;diabetes risk;Disease;DNA Binding Domain;Enhancers;Ethnic Population;exenatide;Exercise;Exons;experience;experimental study;Failure;Female;Foundations;FOXO1A gene;Frequencies;Functional disorder;gain of function;Gene Expression Regulation;Genes;Genetic Transcription;genome wide association study;genome-wide;genome-wide analysis;GLP-I receptor;Glucose;Glucose Intolerance;Glyburide;High Fat Diet;Human;Human Genetics;Hyperglycemia;Hypoglycemia;Impairment;in vivo;insight;Insulin;Insulin Resistance;insulin secretion;Intercistronic Region;islet;Knock-out;Knockout Mice;lactate dehydrogenase A;Lactate Transporter;Link;male;Maps;Messenger RNA;Metabolism;Modeling;Molecular;mouse model;multiple omics;Mus;Mutation;Non-Insulin-Dependent Diabetes Mellitus;novel;OGTT;Pathogenesis;Pathway interactions;Patients;Peripheral;Phenotype;Plasma;precision medicine;Predisposition;prevent;Production;promoter;protein complex;Proteins;Publications;PubMed;Pyruvate;Regulation;Reporter;Reporting;Repression;response;Role;Secondary to;Single Nucleotide Polymorphism;Single Nucleotide Polymorphism Map;Site;Strenuous Exercise;Structure of beta Cell of islet;Sulfonylurea Compounds;Susceptibility Gene;Testing;Therapeutic;Tissues;transcription factor;Untranslated RNA;virtual;Work

PROJECT_TITLE: Decipher the Function of C2cd4a in Metabolism

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Immunotherapy;Neurodegenerative;Neurosciences

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Public Health Relevance Statement/Narrative Targeting inflammation may be key to developing a disease-modifying therapy for Alzheimer’s disease. This project investigates blood and central nervous system biomarkers of inflammation and their modulation by IL-2 administration in people with Alzheimer’s disease. This project will facilitate the development of immunotherapy strategies for various stages of the Alzheimer’s disease process and advance the use of inflammatory biomarkers to assess disease progression or treatment efficacy in Alzheimer’s disease clinical trials.

PI_NAMEs: FARIDAR, ALIREZA  (contact);PASCUAL, BELEN

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Amyloid;Amyloid beta-42;Animal Model;Anti-Inflammatory Agents;Astrocytes;Biological Markers;Blood;Brain;Brain imaging;Cells;Central Nervous System;Cerebrospinal Fluid;chemokine;Chronic;Clinical;Clinical Research;Clinical Trials;Cognition;cytokine;Data;Development;Disease;Disease Progression;Dose;Double-Blind Method;efficacy trial;Encephalitis;Enrollment;Epidemiology;experience;follow-up;Funding;glial activation;Grant;IL2 gene;Immune;Immune system;Immunologic Markers;immunomodulatory therapies;immunoreaction;immunoregulation;Immunotherapy;improved;In Vitro;in vivo;Individual;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;interest;Interleukin-2;Intervention;Light;Link;Macrophage;Measurement;Measures;Mediating;Microglia;monocyte;mouse model;neurofilament;Neuroglia;neuroinflammation;neuroprotection;novel;novel strategies;Outcome;Patient Participation;Peripheral;Persons;Phase;placebo controlled study;placebo group;Plasma;Play;Population;Positron-Emission Tomography;post intervention;Process;Proteins;Proteomics;public health relevance;Randomized;recruit;Regulatory T-Lymphocyte;restoration;risk variant;Role;Safety;safety assessment;Sample Size;Serum;Spinal Puncture;Synapses;tau Proteins;tau-1;Therapeutic Intervention;therapeutic target;Therapeutic Trials;transcriptome;Treatment Efficacy;Up-Regulation;Work

PROJECT_TITLE: Central and peripheral immune cross-talk in Alzheimer's disease and their modulation by a novel immunotherapy


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Racial and ethnic disparities in surgical care and outcomes have been a persistent and well-documented public health problem in the U.S.; however, strategies to effectively close this disparity gap have not been developed. Using an innovative dataset that includes comprehensive information on (1) patient characteristics, (2) surgeon factors, and (3) characteristics of medical schools and residency programs (e.g., the proportion of racial and ethnic minority faculty/peers/patients, the presence of cultural competency programs), the investigators will determine the impact of individual surgeon factors and education/training on racial and ethnic disparities in surgical care and outcomes. This research has the potential to offer novel approaches for unraveling one of the key determinants of disparities in surgery—“surgeon factors”—and to provide a strong evidence base for developing interventions that can effectively reduce racial and ethnic disparities in surgical care.

PI_NAMEs: TSUGAWA, YUSUKE  (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Affect;Age;American;American College of Surgeons;American Medical Association;Association of American Medical Colleges;Awareness;beneficiary;Black race;care costs;Caring;Characteristics;continuing medical education;cultural competence;Data;Data Set;Databases;Death Rate;Disparity;disparity gap;Education;End stage renal failure;Environment;ethnic disparity;ethnic minority;Ethnic Origin;evidence base;experience;Faculty;Failure;Fibrinogen;Funding;Gender;health literacy;Health Services Research;Hispanic;hospital readmission;improved;Individual;innovation;Instruction;International;Intervention;Kidney Transplantation;Knowledge;Language;Lead;Length of Stay;Life;Link;Location;Mastectomy;Medical Residency;medical schools;Medicare;Methods;Minority;minority health;minority health disparity;Minority Health Research;minority patient;Modeling;Morbidity - disease rate;mortality;nonEnglish language;novel strategies;Operative Surgical Procedures;Outcome;Patient Care;Patient-Focused Outcomes;Patients;peer;Physicians;Play;Positioning Attribute;Process;programs;provider factors;Public Health;Quality of Care;Race;racial disparity;racial minority;reconstruction;Research;Research Personnel;Residencies;Resources;Role;Rural;Schools;Socioeconomic Status;statistics;Strategic Planning;Students;Surgeon;surgical disparities;symposium;System;Testing;therapy design;Training and Education;Transplant Recipients;United States National Institutes of Health;urban area;Variant

PROJECT_TITLE: The Impact of Surgeon Factors and Education/Training on Disparities in Surgical Care.


ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: Project Narrative Defects in genes involved in replication stress response often lead to neurodevelopmental disorders and predisposition to cancer. The Coats Plus disease, caused by dysfunction of genes involved in combating replication stress, is a rare genetic disease characterized by developmental failure of multiple vital organs including brain, eye and GI tract. The proposed research aims to reveal a new signaling pathway regulating the cellular response to replication stress and is expected to yield new mechanistic insights into how cells protect genome stability during perturbed replication and how genome instability leads to disease development.

PI_NAMEs: CHAI, WEIHANG  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Acceleration;Affect;Aging;Bilateral;Binding;Binding Proteins;Biochemical;biological adaptation to stress;Biological Assay;Biophysics;Blood Vessels;bone;Brain;calcification;Calcium;Calcium Signaling;Cells;Chromosome Breakage;Coats plus syndrome;Coats' disease;combat;Complex;Cytoprotection;Data;Defect;design;Development;developmental disease;Disease;DNA;DNA biosynthesis;DNA replication fork;Ensure;Enzymes;Event;Exhibits;Eye;Failure;Functional disorder;gastrointestinal;Gastrointestinal tract structure;Genes;Genetic Diseases;Genome;genome integrity;Genome Stability;Genomic Instability;Goals;Growth;Human;insight;Investigation;Knowledge;Life;loss of function mutation;Maintenance;Malignant Neoplasms;Mediating;Microcephaly;Molecular;multidisciplinary;Mutation;Neurodevelopmental Disorder;novel;nuclease;Organ;pathological aging;Pathological Dilatation;Pathology;Pathway interactions;Phospho-Specific Antibodies;Phosphoproteins;phosphoproteomics;Phosphorylation;Predisposition;preservation;prevent;protein function;Proteins;rare genetic disorder;Reagent;recruit;replication stress;Research;response;Retina;Role;Signal Pathway;Signal Transduction;single molecule;Single-Stranded DNA;Site;SS DNA BP;Stress Response Signaling;System;targeted treatment;Technology;Telangiectasis;Testing;therapeutically effective;Up-Regulation;Work

PROJECT_TITLE: Molecular Basis of Coats Plus Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(02)M]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative We remain ignorant about bat henipavirus spillovers through intermediate hosts – including the specific viruses spilling over, the frequency and distribution of spillovers, and the pathways of transmission – at our own peril. Until and unless we better understand and prevent spillovers of bat-borne viruses into intermediate hosts and humans, we will be severely limited in our ability to stop pandemics. The knowledge gained from this study will be immediately applicable to human and animal health programs because if we know which henipaviruses infect humans and domesticated animals, and how they are infected, we can advise public health surveillance programs on how to optimize detection and prevention of infections.

PI_NAMEs: GURLEY, EMILY SUZANNE (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Animals;Anthropology;Antibodies;Area;Australia;Bangladesh;bat-borne;Biological Assay;Bite;Canis familiaris;Cattle;Characteristics;Child;Chiroptera;Consumption;Coronavirus;Country;cross-species transmission;Data;Detection;Disease Outbreaks;Domestic Animals;Ecology;Epidemiology;epidemiology study;Equus caballus;Exclusion;Exposure to;Family Pteropodidae;Family suidae;Felis catus;Frequencies;Fruit;Genus Pteropus;Goat;Health;Hendra Virus;Henipavirus;Henipavirus Infections;Human;Immunology;Infection;Infection prevention;Investigation;Knowledge;Learning;Malaysia;meteorological data;multidisciplinary;Neurologic;Nipah;Nipah Virus;pandemic disease;pandemic potential;Pathway interactions;Persons;Philippines;Phoenix dactylifera;Population Surveillance;prevent;Prevention strategy;programs;prospective;Prospective Studies;Public Health;Reporting;reproductive;respiratory;Risk;RNA Viruses;Route;Sampling;scale up;Serology;serosurvey;Singapore;Site;Statistical Models;Suggestion;Surveillance Program;System;Systematic Bias;transmission process;Trees;United States National Institutes of Health;Update;Vaccines;Variant;Virus;weather patterns

PROJECT_TITLE: Solving Opportunities for Spillover (SOS): Frequency and Mechanisms of Cross-species Transmission of Henipaviruses in Bangladesh

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ORG_CITY: Princeton

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative This project investigates the mechanism by which dynamin enables membrane fission during endocytosis, how SH3 domain-containing proteins interact and regulate dynamin during endocytosis, and how dynamin interacts with actin filaments during various cell processes that rely on the actin cytoskeleton. This work is of public health relevance because dynamin has critical roles in endocytosis necessary for cell signaling, and for cell-cell fusion and migration which require actin bundling by dynamin. Furthermore, dysregulation of dynamin causes neuropathies, cancer and defects in organism development.

PI_NAMEs: JIMAH, JOHN  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Actins;Address;Affect;amphiphysin;Arginine;Binding;Biological Assay;Biomedical Research;biophysical analysis;Biophysics;Bundling;career;Cell fusion;Cell membrane;cell motility;Cell Physiology;Cells;Cellular biology;Cellular Membrane;Charge;Complex;constriction;Cryo-electron tomography;Cryoelectron Microscopy;Cytoskeleton;Defect;Development;Diameter;Dynamin;Electrons;Elements;Endocytosis;Foundations;Goals;GTP Binding;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Hydrolysis;In Vitro;in vivo;insight;intersectin 1;Length;Lipids;Liposomes;Malignant Neoplasms;mechanical properties;Mediating;Membrane;Membrane Lipids;Mentors;Microfilaments;Mission;Modeling;Molecular;Movement;mutant;Neck;Neuropathy;novel;Organism;Play;Polymers;Process;programs;Proline;Proline-Rich Domain;Protein Region;Proteins;public health relevance;reconstitution;reconstruction;recruit;Regulation;Reporting;Research;Research Design;Research Methodology;Research Personnel;Role;SH3 Domains;Signal Transduction;Site;Structure;System;Tertiary Protein Structure;Testing;Tomogram;Training;Transfection;Tube;United States National Institutes of Health;Vesicle;Work

PROJECT_TITLE: Structural basis of dynamin-mediated membrane fission actin bundling and interaction with binding partners.

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS