ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Pain Research;Vulvodynia;Women's Health Research

PHR: PROJECT NARRATIVE Vestibulodynia (VBD) is a complex chronic vulvar pain condition that impairs the psychological, physical, and sexual health of 1 in 6 reproductive aged women in the United States. Here, we plan to conduct a randomized, double-blinded, placebo-controlled clinical trial to 1) compare the efficacy of peripheral (lidocaine/estradiol cream), centrally-targeted (nortriptyline), and combined treatments in alleviating pain and improving patient- reported outcomes and 2) determine cytokine and microRNA biomarkers that predict treatment response in women with distinct VBD subtypes. Positive findings from this study will readily translate to improved patient care, permitting the millions of women with VBD, their partners, and their clinicians to make more informed decisions about pain management.

PI_NAMEs: NACKLEY, ANDREA G (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TERMS: Affect;aged;Anti-Inflammatory Agents;arm;Biological Markers;Blood;Body Regions;Caring;Cell Physiology;Chronic;chronic painful condition;chronic pelvic pain;Clinic Visits;Clinical;Combined Modality Therapy;comparative efficacy;Complex;Controlled Clinical Trials;Cream;cytokine;Data;Double-Blind Method;efficacy evaluation;Equilibrium;Estradiol;Estrogens;Etiology;Exhibits;Functional disorder;functional status;Gene Expression;Health;Immune;Impairment;improved;Inflammation Mediators;Inflammatory;insight;Lidocaine;McGill Pain Scale;Measures;Mediating;Mental Health;microRNA biomarkers;MicroRNAs;multidisciplinary;multiplex assay;Muscle;Nerve;Nerve Pain;Newly Diagnosed;Nortriptyline;Numeric Rating Scale;Outcome Measure;Pain;Pain management;Pain Measurement;pain perception;Participant;Pathology;Pathway interactions;Patient Care;Patient Outcomes Assessments;Patient Self-Report;Peripheral;Phase;Phase III Clinical Trials;physical conditioning;Placebo Control;Placebos;Prediction of Response to Therapy;Process;Production;Proteins;psychologic;Questionnaires;Randomized;recruit;Reporting;reproductive;Research Design;Resort;response;Sampling;Sexual Health;Site;Small RNA;Standardization;Tampons;Testing;Time;Titrations;transcriptome sequencing;Translating;treatment choice;Treatment Efficacy;Treatment Protocols;treatment response;treatment strategy;Tricyclic Antidepressive Agents;United States;Untranslated RNA;Update;Vagina;vestibular system;Vestibule;Vestibulodynia;Vulva;vulvar pain;Woman;women's outcomes;Work

PROJECT_TITLE: Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments (Vestibulodynia: UPDATe)


ADMINISTERING_IC: AA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Pediatric;Prevention;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Underage Drinking

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The pilot data collected for this study will inform the development of a randomized controlled trial evaluating the efficacy of an environmental intervention designed to increase engagement in rewarding alcohol-free social activities and reduce heavy episodic drinking and related negative consequences among college students who are members of a fraternity or sorority. This intervention has the potential to engage a difficult to reach group of college students who are at high-risk of experiencing significant alcohol-related harm, as well as benefit these students by providing alcohol-free alternatives to developing social connections. Environmental approaches such as this are needed to not only change the social context of high-risk drinking environments for college students, but to also provide drinking alternatives to maximize the effects of individual-level alcohol interventions that increase college students' motivation for behavior change.

PI_NAMEs: LEHINGER, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: PARASURAMAN, SARIKA RANE

PROJECT_TERMS: acceptability and feasibility;Address;alcohol availability;alcohol consequences;Alcohol consumption;alcohol free;alcohol free program;alcohol intervention;alcohol measurement;alcohol misuse;alcohol misuse prevention;alcohol related consequences;alcohol reward;Alcohols;Award;behavior change;behavioral economics;binge drinking;brief alcohol intervention;career;catalyst;cohort;Collaborations;Communities;community partners;Conduct Clinical Trials;Consumption;Data;design;Development;Discover, Design, Build, and Test Framework;drinking;drinking behavior;Economic Models;Effectiveness;effectiveness evaluation;efficacy evaluation;Ensure;Environment;environmental intervention;Environmental Monitoring;Event;experience;feasibility testing;Female;Goals;Greek;Heavy Drinking;high risk;high risk drinking;high risk population;Human;human centered design;Hybrids;implementation facilitators;implementation/effectiveness;improved;Individual;innovation;Intervention;intervention effect;Interview;K-Series Research Career Programs;Knowledge;male;Measures;member;Modeling;Motivation;National Institute on Alcohol Abuse and Alcoholism;Outcome;peer;Phase;pilot trial;Play;Precipitating Factors;prevent;Prevention;Prevention strategy;Process;programs;Psychological reinforcement;Public Health;Randomized, Controlled Trials;recruit;Research;Research Methodology;Research Personnel;Rewards;Risk;Role;satisfaction;Schools;skills;social;social attachment;Social Change;Social Environment;social factors;Social Interaction;Social Reinforcement;Societies;student participation;Students;substance use;Surveys;Testing;theories;therapy design;therapy development;Time;Training;Universities;university student;usability;young adult;young adult alcohol use

PROJECT_TITLE: Increasing Availability of and Engagement In Alcohol-Free Social Activities to Address Heavy Episodic Drinking and Alcohol Consequences Among Fraternity and Sorority College Students

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Data Science;Drug Abuse (NIDA only);Social Determinants of Health;Substance Misuse

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Narrative Statement There is an increasing number of publicly available complex, large, longitudinal datasets, and a corresponding urgent need for new, accessible opportunities to educate scientists in the responsible use of these data. This R25 will address this urgent need by imparting high quality training in longitudinal data analytic skills to 150 diverse academic and non-academic participants, while also training 18 diverse graduate students to effectively teach these methods, thereby increasing the quality of the instructional workforce as well.

PI_NAMEs: CHRIST, SHARON LOUISE;MARCEAU, KRISTINE  (contact);MCCANN, JAMES ALEXANDER;MIZE, TRENTON D

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: Academia;Adolescent;All of Us Research Program;analytical method;Behavioral;Behavioral Sciences;Biological;Brain;career;cognitive development;Collaborations;collaborative environment;college;Communication;Complex;complex data;Computer software;Consultations;Course Content;Data;Data Analyses;Data Analytics;data management;Data Set;Data Sources;data visualization;design;Development;Discipline;Discipline of Nursing;Education;Educational process of instructing;Educational workshop;Elements;Evaluation;experience;Faculty;Family;Family Study;Future;Gender;Government Agencies;graduate student;Health;Health Sciences;heterogenous data;Home;Hour;Human Development;improved;Individual;Industry;innovation;insight;Institution;Instruction;instructor;interdisciplinary approach;interdisciplinary collaboration;interest;Investments;Joints;Leadership;learning community;learning materials;lectures;longitudinal dataset;Measurement;Mentors;Mentorship;Methodology;Methods;Minority-Serving Institution;Mission;Modeling;multiple data sources;Neighborhoods;open data;Participant;Patient Recruitments;Politics;Population;Postdoctoral Fellow;Program Evaluation;programs;protective factors;recruit;Research;Research Design;Research Personnel;Risk Factors;Sampling;Science;Scientist;skills;social;social genomics;Social Sciences;Sociology;Source;Statistical Data Interpretation;Stratification;Structure;Students;substance use;summer institute;teaching assistant;Teaching Method;theories;Time;Training;training data;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities;Visualization;web site;Weight;Work

PROJECT_TITLE: Interdisciplinary Summer Institute on the Analysis of Complex, Large-Scale Longitudinal Data

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 LXF-N (A1)]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Hematology;Infectious Diseases;Neurodegenerative;Neurosciences;Sepsis;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CHARLESTON

ORG_DEPT: PATHOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The goals of our research program are to gain a deep understanding of the mechanisms behind pericyte activation, subsequent pericyte loss, and their impact on cerebrovascular dysfunction in sepsis-induced cognitive impairment and to develop novel targeted treatment to sepsis-associated encephalopathies. To advance our research goals, we are seeking to acquire the Ultima Investigator Plus two-photon microscope. This cutting-edge technology will enable us to enhance the precision and depth of our investigations.

PI_NAMEs: FAN, HONGKUAN  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;Affect;Animal Model;anti-IgG;Antibodies;Antisense Oligonucleotides;Apoptosis;Apoptotic;Astrocytes;Autopsy;Blood;Blood - brain barrier anatomy;Blood capillaries;Blood Vessels;Brain;brain cell;brain pericytes;brain tissue;Breeding;CASP1 gene;CASP3 gene;CCL2 gene;Cell Adhesion Molecules;Cell Nucleus;Cells;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;chemokine;comparison control;conditioned fear;Confocal Microscopy;cytokine;Cytometry;Dendritic Spines;density;Development;DLG4 gene;Encephalopathies;Endothelial Cells;Endotoxemia;Exhibits;Extravasation;FLI1 gene;FLI1 Transcription Factor;Flow Cytometry;FOS gene;Functional disorder;Goals;Hippocampus;Hour;Human;ICAM1 gene;Image;Immediate-Early Genes;Immunoglobulin G;Impaired cognition;Impaired health;improved;In Situ Nick-End Labeling;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Infiltrate;Investigation;Knockout Mice;Laboratories;Lead;Leukocytes;Memory impairment;Mental Health;Methods;Microglia;Microscope;monocyte;mouse model;Mus;neuroinflammation;neuron apoptosis;neuron loss;Neuronal Dysfunction;Neurons;neurovascular unit;neutrophil;novel;Pathologic;Patients;PECAM1 gene;Pericytes;Persons;Play;Production;programs;Proteins;recruit;Reporting;Research;Research Personnel;response;Reverse Transcriptase Polymerase Chain Reaction;Role;Sampling;Sepsis;septic patients;Serum;Signal Transduction;single nucleus RNA-sequencing;Stains;Superior temporal gyrus;Survivors;Synapses;synaptogenesis;targeted treatment;Technology;Testing;Therapeutic;treatment strategy;two-photon;United States National Institutes of Health;Vascular Cognitive Impairment;Vascular Diseases;Vesicle;Visualization;Western Blotting;Wild Type Mouse

PROJECT_TITLE: The Role of Pericytes in the Vascular Dysfunction of Sepsis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(01)-Q]


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: DURHAM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: The emergence of multidrug resistant microbes is a serious threat to human health. Delineating the molecular mechanisms behind essential processes unique to microbes presents opportunities for rational design of specific therapeutics to combat this growing concern.

PI_NAMEs: SCHUMACHER, MARIA  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Ammonium;anti-microbial drug;Antibiotics;Antimicrobial Resistance;Area;Bacteria;bacterial resistance;Biochemistry;Biological;Biological Process;Cessation of life;combat;Complex;Cryoelectron Microscopy;Cues;Development;dimer;drug development;drug resistant microorganism;Drug Targeting;Elements;environmental change;Enzymes;Generations;Glutamate-Ammonia Ligase;Glutamine;Goals;Health;Homeostasis;Human;in vivo;interest;Ions;Laboratories;Metabolic;Methanosarcina;Microbe;microbial;Modeling;Molecular;Molecular Target;Multi-Drug Resistance;Nitrogen;novel;Nucleic Acids;Pathogenesis;Photometry;Physiological;Predisposition;Process;Proteins;rational design;Regulation;Signal Pathway;Signal Transduction;Therapeutic;X-Ray Crystallography

PROJECT_TITLE: Deciphering fundamental biological processes involving protein-nucleic acid interactions at the molecular level


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE Although progress has been made in the development of ViCPS-conjugate vaccines for typhoid, the majority of fatal systemic Salmonellosis is caused by bacterial that lack expression of ViCPS. CD4 Th1 memory T cells are required to resolve this non-typhoid systemic disease, meaning that new vaccine approaches will be required. This application explores a new mRNA vaccine approach for Salmonella that attempts to elicit hepatic Tissue-Resident Memory Th1 cells. Our preliminary data show that these cells are essential for protection and differ from other TRMs in expression of IL-18R. Our goal is to test the requirement for IL-18R in protective immunity and elicit TRMs using an mRNA vaccine approach. Successful completion of this exploratory project will validate a new approach to vaccination for intra-macrophage pathogens.

PI_NAMEs: MCSORLEY, STEPHEN J (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Activities of Daily Living;Address;Adoptive Transfer;Age Months;Alleles;Anatomy;Antigens;Antimicrobial Resistance;Blood;Cause of Death;CD4 Positive T Lymphocytes;Cells;Cessation of life;Child;Conjugate Vaccines;Data;design;Development;effective therapy;experimental study;Gene Expression Profile;genome wide association study;Goals;Hepatic Tissue;Heterogeneity;Immunity;Immunization;improved;Infection;Intestines;Knowledge;Laboratories;Lamina Propria;Licensing;Life;Liver;liver inflammation;Location;LoxP-flanked allele;Lymph;Mediating;Memory;memory CD4 T lymphocyte;Messenger RNA;MHC Class II Genes;mouse model;Mus;nanoparticle delivery;novel strategies;novel vaccines;pathogen;Phenotype;Population;pre-clinical research;Predisposition;prevent;protective efficacy;Research Priority;residence;Resistance;RNA vaccine;Salmonella;Salmonella enterica;Salmonella infections;Salmonella typhi;Subunit Vaccines;System;Systemic disease;Systemic infection;T memory cell;T-Lymphocyte;Testing;Th1 Cells;Tissue Model;Tissues;Typhoid Fever;Typhoid Vaccine;Vaccinated;Vaccination;vaccine access;vaccine development;vaccine efficacy;Vaccines;Work;World Health Organization

PROJECT_TITLE: Vaccine induction of Salmonella-specific Th1 memory cells

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: CHAPEL HILL

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Administrative Supplement to Purchase Thermocycler Instruments Summary of Parent Grant RNA functions as the central conduit of information exchange in all cells. RNA molecules encode this information in both their primary sequences and in complex structures that form when RNA folds back on itself. The broad and fundamental importance of RNA structure is clear, but there remains a profound knowledge gap: We generally have only rudimentary understanding of RNA structure across vast regions of most messenger and non-coding RNAs. We need to move beyond modeling RNA structure to directly detecting through-space structural communication and interactions in cells. In essentially every instance where we have applied rigorous and quantitative technologies to study RNA structure-function interrelationships, new insights regarding biological regulatory mechanisms have emerged. We have also shown that RNA elements with higher-order structures are more likely to contain high-information-content clefts and pockets that bind small molecules, broadly informing a vigorous field of RNA-targeted drug discovery. Our work has sustained long-term impact due to pursuing three overarching opportunities. First, the project focuses on development of decisive, concise, and broadly implementable technologies for discovering and assessing higher-order structure in RNA. Second, this project applies these direct and experimentally concise methods to challenges of broad importance, from identification of structures essential for replication of pathogenic viruses to understanding how RNA conformational ensembles govern transcriptional gene regulation and pre-mRNA splicing. Third, understanding the propensity of RNA to form higher-order structures – and often clefts and pockets – opens up the possibility of targeting these motifs with small molecules, an opportunity we will exploit with the long-term goal of inventing facile and straightforward strategies for creating RNA-targeted therapeutics. Overview of Need for Equipment Purchase This administrative supplement requests funds to purchase and replace thermocycler instruments to be used by the Weeks research laboratory, which is currently supported by NIGMS R35 GM122532 (Dr. Michael Sakalian, PO). The cost of the essential instruments is $19,999.98 and is outside the range of equipment that can be purchased in the context of the current budget. Our grant budget is fully encumbered, and will zero out, for the next year. The requested instrument will be shared and used by multiple members of the Weeks group. The need for replacement thermocyclers was unforeseen at the time of the original research proposal. Thermocyclers are essential for all modern RNA genomics experiments. Our current, non-functional instruments were purchased in 2012, twelve years ago. Stuff breaks, and we absolutely need to replace these instruments to do our MIRA-funded work. We need two instruments due to the volume of work and sequencing that we do. Diverse researchers will benefit from this purchase. The thermocycler instruments will be used by all Weeks group members, from undergraduates to postdocs (14 total). The simple operating design and user interface of the requested instruments will allow all members of the lab to use the instruments efficiently. Plan for training and upkeep. The instruments will be maintained by the Weeks lab. A lead user in our laboratory will be assigned and will facilitate training and ensure the instruments operate efficiently.

PI_NAMEs: WEEKS, KEVIN M (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Acceleration;Administrative Supplement;Adopted;Back;Binding;Biological;Biomedical Research;Biotechnology;Budgets;Cells;Communication;Complex;cost;design;Development;drug discovery;Elements;Ensure;Equipment;equipment acquisition;experimental study;Funding;Gene Expression Regulation;Genetic Transcription;genomic RNA;Genomics;Goals;Grant;Higher Order Chromatin Structure;insight;instrument;invention;Knowledge;Laboratories;Laboratory Research;Lead;Libraries;Massive Parallel Sequencing;member;Messenger RNA;Methods;Modeling;Modernization;mRNA Precursor;National Institute of General Medical Sciences;parent grant;parent project;pathogenic virus;Postdoctoral Fellow;Preparation;programs;Research;Research Personnel;Research Proposals;Research Support;Reverse Transcriptase Polymerase Chain Reaction;RNA;RNA Conformation;RNA Folding;RNA Splicing;RNA-targeting therapy;small molecule;Structure;Technology;Time;Training;undergraduate student;Untranslated RNA;Work

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Narrative Azoles are common antifungal agents widely-used in clinical applications and agriculture. In vertebrates, exposures to azoles during early embryonic development results in developmental toxicity outcomes, including, craniofacial and axial defects. In this study, we aim to delineate mechanisms underlying azole-induced developmental toxicity utilizing single cell transcriptomic-based approaches, gene-editing tools, and established alternative model systems of early embryonic development.

PI_NAMEs: ROBINSON, JOSHUA FREDERICK (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: adverse outcome;Agriculture;Animals;anti-fungal agents;Azoles;Biological Availability;Biological Models;Branchial arch structure;Cell Differentiation process;Cell Lineage;Cell Proliferation;Cell Wall;Cells;Chemical Exposure;Chemicals;Classification;clinical application;Congenital Abnormality;craniofacial;CRISPR/Cas technology;Custom;Cytochrome P450;Data;data integration;Data Set;Defect;Dermal;design;Development;developmental toxicity;developmental toxicology;differential expression;Dysmorphology;Embryo;embryo cell;embryo culture;Embryonic Development;Endocrine;environmental chemical;enzyme pathway;Event;Exposure to;flusilazole;gene editing technology;Gene Expression;Genes;Genetic;genetic signature;Genetic Transcription;genome editing;Goals;hazard;Health;hindbrain;Homeobox Genes;Human;human embryonic stem cell;Impairment;in silico;In Vitro;innovation;insight;Intravenous;Investigation;Laboratories;Libraries;Ligands;Link;Lipids;malformation;Maps;Medicine;Metabolism;Modeling;Molecular;molecular phenotype;Molecular Target;Morphology;nerve stem cell;neural;Neural Tube Development;novel;Nuclear;Oral;Organism;Organogenesis;Outcome;Pathway interactions;Pattern;Phenotype;Predisposition;Pregnancy;Pregnant Women;Proliferating;Rattus;Risk;RNA;Rodent;Role;Route;Safety;Signal Pathway;Signal Transduction;single-cell RNA sequencing;spatiotemporal;stem cell model;steroid metabolism;Sterols;System;Teratogens;Testing;Time;tool;Toxic effect;Toxicity Tests;Toxicogenomics;Toxicology;transcriptome;transcriptome sequencing;transcriptomics;Tretinoin;Validation;Vertebrates;Zebrafish

PROJECT_TITLE: Delineating mechanisms underlying azole-induced developmental toxicity using single cell transcriptomic approaches, genome editing tools, and alternative models


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: MOSCOW

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PI_NAMEs: BOHACH, CAROLYN HOVDE (contact)

PROGRAM_OFFICER_NAME: ARORA, KRISHAN


ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Neuronal plasticity is how neurons change their connections with other neurons and is essential for normal brain development and function. However, plasticity also underlies addiction and is misregulated in disorders such as autism and schizophrenia. We propose to identify and study novel molecular mechanisms of neuronal plasticity, using circadian clock neurons as neurons with highly predictable plasticity.

PI_NAMEs: BLAU, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Actins;addiction;autism spectrum disorder;Brain;Cerebral hemisphere;circadian pacemaker;Cognition Disorders;Development;Disease;disorder risk;Drosophila genus;Ensure;fly;Gene Expression;Genes;Genetic;Genetic Transcription;Genomics;Goals;Guanosine Triphosphate Phosphohydrolases;Human;insight;Learning;Mammals;Mental disorders;Molecular;Morphology;Mutation;Neurobiology;Neuronal Plasticity;Neurons;novel;Pathway interactions;posttranscriptional;Probability;programs;Property;response;risk variant;Schizophrenia;Sleep;Specific qualifier value;Synapses;Testing;tool;Toy;transcription factor;Translations;Visualization;Work

PROJECT_TITLE: Molecular mechanisms of neuronal plasticity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Data Science;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Substance Misuse

ORG_CITY: MIAMI

ORG_DEPT: PHYSICS

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE This project supports the ABCD-ReproNim Educational Program, which provides research training in responsible, reproducible, and valid analyses of data from the Adolescent Brain Cognitive Development (ABCD) Study. Participants first receive didactic training across a 16-week online course that includes lectures, readings, and data exercises; at the completion of the course, participants will contribute to team-based, collaborative data analysis projects during a five-day hackathon at the host institution, Florida International University, in Miami, Florida. Program success will result in well-trained researchers who are able to apply responsible, reproducible, and valid practices to ABCD data, affording them the opportunity to better utilize the valuable ABCD resource.

PI_NAMEs: KENNEDY, DAVID NELSON;LAIRD, ANGELA R (contact);THOMPSON, WESLEY KURT

PROJECT_TERMS: Address;Adolescent;Applied Skills;Behavioral;Behavioral Research;Biomedical Research;Brain;Child Health;Clinical Research;cognitive development;Collaborations;Communities;Complex;Creativeness;Data;data acquisition;Data Analyses;Data Set;data sharing;design;Development;Education;education research;Educational Curriculum;Exercise;experience;Faculty;Feedback;flexibility;Florida;Funding;Generations;Genomics;Goals;hackathon;hands on instruction;Health;Hybrids;innovation;Institution;Instruction;instructor;International;Knowledge;large datasets;large scale data;Learning;lectures;Longitudinal Studies;member;Modeling;multidisciplinary;National Institute of Biomedical Imaging and Bioengineering;National Institute of Drug Abuse;neuroimaging;online course;online repository;Outcome;Participant;population based;Preparation;Program Development;programs;Protocols documentation;Reproducibility;Research;Research Methodology;Research Personnel;Research Training;Resource Development;Resources;Schedule;skill acquisition;Social Environment;Structure;student participation;student training;Students;success;support tools;teaching assistant;Techniques;Time;Training;Training and Education;training data;Training Programs;Underrepresented Populations;United States;Universities;Vision;Work

PROJECT_TITLE: ABCD-ReproNim: An Educational Program for Responsible and Reproducible Analyses of Complex, Large-Scale Data


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative There is a significant number of people living with HIV who are also substance users. Cocaine use represents a comorbidity that worsens the neurological outcomes of HIV infection. This study proposes to research the mechanisms that underlie altered addictive substance seeking behavior in persons living with HIV.

PI_NAMEs: BARKER, JACQUELINE M;DAMPIER, WILLIAM ;JACKSON, JOSHUA GOODYEAR;KLASE, ZACHARY ALAN (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Abstinence;Address;analysis pipeline;Animal Behavior;Animals;antiretroviral therapy;Architecture;Astrocytes;Behavior;Behavioral;behavioral outcome;Blood Vessels;Brain;Brain region;Cell Nucleus;cell type;Cells;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;Chromatin Structure;Chronic Disease;Cocaine;cocaine exposure;cocaine relapse;cocaine seeking;cocaine self-administration;cocaine use;Cognitive;comorbidity;Computational Biology;craving;Data;Development;DNA Packaging;DNA Sequence;Dopamine;drug seeking behavior;Drug usage;Epigenetic Process;Gene Expression;Genetic Transcription;Goals;high resolution imaging;Histology;Histone H3;histone modification;Histones;HIV;HIV Infections;Human;Image;Image Analysis;imaging study;Individual;Infection;Infection prevention;inhibitor;Laboratories;Literature;Machine Learning;machine learning pipeline;Macrophage;Methods;Microglia;Microscopy;Modality;Modeling;Modernization;Modification;Molecular;mouse model;Mus;Myeloid Cells;National NeuroAids Tissue Consortium;neural;neuroAIDS;neurobehavioral;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurological outcome;neuropathology;new technology;non-invasive imaging;novel;Nuclear;Pattern;Penetrance;Persons;Pharmaceutical Preparations;Phase;Physiology;Population;preservation;Property;Protocols documentation;Publishing;recruit;Regulation;Relapse;relapse risk;Research;Risk;Risk Reduction;Rodent;Sampling;substance use;Substance Use Disorder;substance user;System;Techniques;Technology;Testing;Therapeutic;Tissue Banks;Tissue imaging;Tissues;transcription factor;Viral Proteins

PROJECT_TITLE: Examination of epigenetic spatial architecture in the CNS as a method to understand cocaine relapse in ecoHIV infected mice

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 IXR-N (A1)]


ADMINISTERING_IC: OD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: PROJECT NARRATIVE: The major goal of this administrative supplement application for the Parent Grant P40 of the Caribbean Primate Research Center (CPRC) is to improve and expand the storage and housing areas at the Sabana Seca Field Station. This in turn is essential to support any expansion of the Center's IO rhesus colony. The CPRC is one of the most important national resources for any research program using indian- origin (IO) rhesus macaques with no history of admixture and with well-defined genetic and virological backgrounds. Since 1938, the Center has supplied the scientific community with Indian origin rhesus macaques with known backgrounds and of the same genetic pool for use in studies of basic biology and diseases. In the last three years (2020-2023), 700 animals (app 230/year) have been available from this program in support of NIH-high priority HIV/AIDS-research, mainly R01, P01, U01- funded academic investigators and NIAID-DAIDS-SVEU programs. The CPRC has vast experience in the establishment and maintenance of rhesus macaque breeding colonies. The animal care and use program of the CPRC is in compliance with the directives established by the Animal Welfare Act (AWA), PHS and other agencies. The Center is AAALAC fully- accredited. The population management program has been designed to optimize the health and well-being of the monkeys, enhance the value of the colony for research, and provide healthy animals to the scientific community for a variety of studies. The Center is in the urgent need of creating storage area and to renovate a quarantine housing area needed when SPF candidates animals undergoes viral testing. This renovation will support the CPRC to achieve the objective of the expansion and maintenance of the SPF-P40 colony within the original scope of the parent grant.

PI_NAMEs: BURGOS-RODRIGUEZ, ARMANDO GIL;MARTINEZ, MELWEEN I. (contact);SARIOL, CARLOS A

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Accreditation;Acquired Immunodeficiency Syndrome;Administrative Supplement;Admixture;animal care;Animal Housing;Animal Welfare Act;Animals;Area;Biological Models;Biology;Biomedical Research;Breeding;Caribbean region;Cells;China;co-infection;Communicable Diseases;Communities;comorbidity;cost effective;COVID-19 pandemic;design;Dietary Supplementation;Disease;Engineering;Environment;environmental enrichment for laboratory animals;Etiology;experience;Food;Funding;Future;Genetic;germ free condition;Goals;Grant;Health;HIV/AIDS;Housing;Human;improved;India;Intervention;Island;Journals;Long COVID;Macaca;Macaca mulatta;Maintenance;Major Histocompatibility Complex;Medicine;Methods;Microbe;microbicide;Monkeys;National Institute of Allergy and Infectious Disease;Nature;nonhuman primate;parent grant;Parents;Peer Review;Personal Satisfaction;Population;Primates;programs;Provider;Publications;Puerto Rico;Quarantine;Recording of previous events;Reporting;Research;Research Activity;research and development;Research Personnel;Resources;Rhesus;Science;Severe Acute Respiratory Syndrome;Simian Retroviruses;SIV;Study models;System;Testing;therapeutic development;United States National Academy of Sciences;United States National Institutes of Health;vaccine development;Vaccines;Variant;Viral;virology;Virus;virus testing;Weather;Work

PROJECT_TITLE: Caribbean Primate Research Center Program


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Fragile X Syndrome;Genetics;Infectious Diseases;Influenza;Intellectual and Developmental Disabilities (IDD);Pediatric;Pneumonia and Influenza;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative We will investigate the mechanism of translational control by FMRP and its paralogs, FXR1 and FXR2, which may help find a treatment for fragile X syndrome. Additionally, we will investigate the mechanism of translation initiation on influenza A virus mRNAs, which could provide insights for developing drugs to treat influenza infections.

PI_NAMEs: JOSEPH, SIMPSON  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: American;Anti-viral Agents;autistic behaviour;autosome;Binding;Biochemical;biophysical techniques;Brain;Cells;Cellular Stress;Cessation of life;Childhood;Code;Complex;Conserved Sequence;Data;Development;Disease;Drug Targeting;Eukaryotic Initiation Factor-4E;FMR1 gene;Fragile X Syndrome;FXR1 gene;FXR2 gene;Gene Silencing;Genes;In Vitro;Influenza A virus;influenza infection;insight;Intellectual functioning disability;Knowledge;Mammals;Messenger RNA;Molecular;mRNA Expression;paralogous gene;Patients;Persons;Pharmaceutical Preparations;Poly(A)-Binding Proteins;Process;programs;Protein Biosynthesis;Proteins;Public Health;recruit;Regulation;Research;Resistance;RNA-Binding Proteins;Seizures;System;Techniques;Translation Initiation;Translations;Untranslated Regions;Viral;Virus Diseases

PROJECT_TITLE: Mechanism of Protein Synthesis and Translational Control

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Public Heath Relevance Statement: Project Narrative The emergence of multi-drug resistant (MDR) bacterial pathogens and highly zoonotic viruses has greatly threatened animal and human health over the past decades. In this cooperative agreement, the UI VDL is pleased to assist the Vet-LIRN program to 1) respond to complaints in animal food and treats, 2) collect bacterial pathogens and examine their antibiogram to help the program to develop antimicrobial stewardship for veterinary and human medicine practitioners, 3) participate in Vet-LIRN-led proficiency tests and new test development and validation to enhance the accuracy of diagnostic approaches. We expect the participation of the UI VDL will facilitate the Vet-LIRN program to promote animal health and consolidate the veterinary diagnostic network.

PI_NAMEs: HUNG, CHIEN-CHE  (contact);WHITELEY, HERBERT E

PROGRAM_OFFICER_NAME: CERIC, OLGICA

PROJECT_TITLE: University of Illinois Veterinary Diagnostic Laboratory participation in Veterinary Laboratory Investigation and Response Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CVM-K (01)]


ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA COMMUNITY HEALTH CTR/ASSN

PHR: NARRATIVE: Increasing the diversity of clinical trial participants is key to advancing health equity. This project aims to increase the recruitment of diverse participants in research through established provider and community health worker relationships in minority communities using new, interactive community driven curricula.

PI_NAMEs: HAYES, REBECCA  (contact)

PROGRAM_OFFICER_NAME: LEE, CHRISTINE

PROJECT_TITLE: Improving Multicultural Engagement in Clinical Research through Partnership with Federally Qualified Health Centers and Community Health Worker Programs


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: Project NarraƟve Ion channels control the electrical excitability in the brain and the heart, and defects in these channels cause many human disorders. Our long-term goal is to understand how these channels work at the molecular level so that we can better understand their role in the physiology of the brain and heart.

PI_NAMEs: ZAGOTTA, WILLIAM N (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Acceleration;Allosteric Regulation;Brain;Cell membrane;Cells;Confocal Microscopy;conformational conversion;Defect;Dependence;Disease;Equilibrium;Equipment;experimental study;Fluorescence;Fluorescence Resonance Energy Transfer;Goals;Heart;Human;Ion Channel;Ions;Ligands;Measures;Methods;Molecular;Molecular Conformation;Molecular Machines;Molecular Structure;Neurotransmitters;parent grant;parent project;Physiology;Proteins;Resolution;response;Role;Second Messenger Systems;single molecule;single-molecule FRET;small molecule;Stimulus;System;Time;voltage;Work

PROJECT_TITLE: Structural energetics of voltage- and ligand-dependent gating in ion channels


NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE The goal of this proposal is to study the impact of HIV-1 persistence and methamphetamine on central nervous system inflammation and injury in brain tissue from people with HIV that died suddenly out of hospital. We will leverage the unique San Francisco POstmortem Systematic InvesTigation of Sudden Cardiac Death (POST SCD) study for in-depth virus-host-drug interaction studies directly in the brain.

PI_NAMEs: HENRICH, TIMOTHY JENSEN (contact);TSENG, ZIAN H

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;analytical tool;antiretroviral therapy;Astrocytes;Autopsy;Biological Assay;Brain;Brain Injuries;brain parenchyma;Brain Pathology;Brain region;brain tissue;Cell Communication;Cells;Central Nervous System;clinically relevant;cohort;comorbidity;County;Cryopreserved Tissue;Data;digital;Disease;Drug Interactions;Drug usage;Environment;Formalin;Freezing;Functional disorder;Gene Expression;Genetic Transcription;Genomics;Goals;Health;high dimensionality;Histologic;HIV;HIV Infections;HIV-1;Hospitalization;Hospitals;Immune;Immune response;Immunohistochemistry;Immunologic Factors;In Situ;In Situ Hybridization;in vivo;Individual;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;insight;Investigation;Location;Malignant Neoplasms;Mediating;Medical Examiners;Methamphetamine;methamphetamine use;Microglia;Molecular;Morbidity - disease rate;multiple omics;Myelogenous;Myeloid Cells;Nature;nerve injury;neural;neuroinflammation;novel;Nucleic Acids;Paraffin Embedding;Persons;Pharmaceutical Preparations;Phase;Phenotype;preservation;Process;prospective;Protocols documentation;Research;Resolution;Resources;Sampling;San Francisco;Signal Transduction;substance use;sudden cardiac death;Sudden Death;synergism;Testing;Time;Tissue Embedding;Tissues;tool;Transcript;transcriptome;transcriptomics;Viral;Virus

PROJECT_TITLE: In situ spatial characterization of CNS HIV-host cellular interactions from victims of sudden death


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Latines in the U.S. are vastly underserved in access to mental healthcare, with even larger disparities seen in Latines with limited English proficiency. The purpose of this K08 proposal is to refine, implement, and evaluate the feasibility of a community health worker (CHW) delivered, transdiagnostic, evidence-based treatment in Spanish with Latine parents. The knowledge gained from this proposal will address a critical need for evaluating and understanding the implementation of CHW mental health models as a means of reducing treatment disparities for underserved communities.

PI_NAMEs: GUSTAFSON, ERIKA LUZ (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: acceptability and feasibility;Address;Aftercare;Anxiety;anxious;Area;Attention;career;Chicago;Child;Child Mental Health;Clinic;Clinical;Clinical Trials;Collaborations;Communities;community advisory board;community engagement;Community Health Aides;community setting;Consolidated Framework for Implementation Research;cultural competence;Data;Data Reporting;depressive symptoms;design;Diagnostic;Disparity;disparity reduction;Effectiveness;effectiveness evaluation;effectiveness trial;effectiveness/implementation trial;Elements;Environment;Equity;Ethics;Ethnic Population;Evaluation;evidence base;Evidence based treatment;Family;Future;global health;Goals;Health;health care availability;health care disparity;health equity;Health Expenditures;Health Personnel;health training;Home;Hospitals;Household;implementation determinants;implementation evaluation;implementation framework;implementation intervention;Implementation readiness;implementation science;Improve Access;improved;improved outcome;Individual;Inequity;innovation;Institution;intergenerational;Interruption;Intervention;Investments;Knowledge;Language;Latinx;Lead;Limited English Proficiency;Linguistics;Link;marginalization;marginalized community;marginalized population;Measurement;Measures;member;Mental Depression;Mental disorders;mental function;Mental Health;Mental Health Services;Methods;Minority Groups;minority health disparity;Modeling;National Institute of Mental Health;organizational readiness;Outcome;Parents;Patients;Persons;Population;Positioning Attribute;Prevalence;Procedures;Process;Provider;Psychopathology;Public Health;Randomized;randomized trial;recruit;Research Personnel;Research Project Grants;Resource-limited setting;Resources;Risk;safety net;Savings;Scientist;Services;skill acquisition;social health determinants;Social Identification;social stigma;Spanish;stress symptom;Symptoms;System;therapy design;Training;Translating;Trauma;traumatic stress;treatment comparison;treatment disparity;underserved community;Underserved Population

PROJECT_TITLE: Community health worker implementation of transdiagnostic evidence-based treatment in Spanish: Advancing mental health equity for Latine parents

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (O1)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STANFORD

ORG_DEPT: SURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project narrative The junctional epithelium (JE) serves as the first line of defense against periodontal diseases, and its barrier functions are maintained by a stem cell niche. Here, we will identify and characterize the roles of Wnt/β-catenin signaling in maintaining the stem cell pool during JE homeostasis and during injury repair. We also test a biochemical approach for re-establishing JE barrier functions after damage and disease that, if successful, opens up new avenues for periodontal disease treatment and prevention.

PI_NAMEs: HELMS, JILL A (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Address;Adenoviruses;alveolar bone;Anatomy;beta catenin;Biochemical;Bone Morphogenetic Proteins;Bromodeoxyuridine;Cell Cycle;Cell Cycle Kinetics;Cell Differentiation process;Cells;Clinical;Connective Tissue;Data;Dental Cementum;Differentiation Antigens;Disease;Embryo;Epithelial Attachment;Epithelial Cell Junction;Epithelial Cell Proliferation;Epithelial Cells;epithelial stem cell;Epithelium;epithelium regeneration;Excision;experimental study;Exposure to;Flow Cytometry;Fluorescent in Situ Hybridization;Formulation;Gene Expression Profile;Gene Expression Profiling;Genes;Gingiva;Gingivectomy;Goals;Harvest;Health;Hemidesmosomes;Heterogeneity;Histology;Homeostasis;Human;Immunoglobulin G;Immunohistochemistry;Infiltration;Inflammatory;inhibitor;Injury;injury and repair;innovation;insight;Jaw;Knowledge;Label;Libraries;Ligature;lipid nanoparticle;Maintenance;Mediating;Modeling;Molecular;Mus;Natural regeneration;new therapeutic target;notch protein;novel therapeutic intervention;Operative Surgical Procedures;Oral;Oral cavity;Pathway interactions;Periodontal Diseases;Periodontal Ligament;Periodontitis;Placebos;Population;preservation;Prevention;Prevention strategy;Proliferating;protein distribution;Recombinants;Regenerative capacity;repair model;Reporter;Research Personnel;restoration;RNA Probes;Role;self-renewal;Series;Signal Transduction;Site;Skeleton;soft tissue;Sorting;Source;Stains;stem cell biomarkers;stem cell niche;stem cell self renewal;stem cells;Tamoxifen;targeted treatment;Testing;Therapeutic;therapeutic protein;Tissues;Tooth structure;tooth surface;Tracer;Wnt proteins;WNT Signaling Pathway;Wnt-3A protein;Work;wound healing

PROJECT_TITLE: Molecular mechanisms mediating the soft tissue attachment to teeth

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Macrophages, a component of our immune system, have a paradoxical role in cancer – they can promote metastasis. We previously discovered that macrophages spill their internal contents into cancer cells during metastasis, but what is the functionally important information in the contents? We recently discovered that mitochondria are transferred, and we seek to answer how thieving even small amounts of mitochondria can drive big changes in cancer cell metastasis.

PI_NAMEs: ROH, MINNA  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: 8-hydroxy-2'-deoxyguanosine;base;Breast Cancer Cell;cancer cell;carcinogenesis;cell behavior;Cell Physiology;Cell Proliferation;cell type;Cells;Clinical;Coculture Techniques;Communication;Critical Illness;Cytoplasm;Data;Development;DNA;DNA Damage;ds-DNA;Environment;Exhibits;experimental study;Exposure to;Flow Cytometry;Future;Gene Expression;Generations;Genes;Goals;Guanine;Homeostasis;Human;Immune;Immune system;Immunotherapy;in vivo;inhibitor;Injections;knock-down;Lateral;Macrophage;Malignant Neoplasms;Mediating;Melanoma Cell;Microscopy;Mitochondria;Mitochondrial DNA;mouse model;Neoplasm Metastasis;neoplastic cell;NF-kappa B;Organelles;Pathway interactions;pharmacologic;Play;Population;Positioning Attribute;Primary Neoplasm;Process;programs;Proliferating;Proteins;Reactive Oxygen Species;recruit;Respiration;Role;Sentinel;Signal Transduction;stem;Stimulator of Interferon Genes;Stromal Cells;Superoxides;Testing;Theft;Therapeutic;Transplantation;tumor;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumorigenic;Visualization;Work;Zebrafish

PROJECT_TITLE: Mitochondrial lateral transfer during metastasis


NIH_SPENDING_CATS: Aging;Arthritis;Biotechnology;Breast Cancer;Cancer;Clinical Research;Osteoarthritis;Osteoporosis;Rare Diseases;Women's Health Research

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE  Conditions such as osteoporosis, osteoarthritis, osteomyelitis; developmental skeletal abnormalities; and malignancies such as multiple myeloma and breast cancer, negatively affect the skeleton. There is an ongoing need to better understand the causes of these diseases to support the development of more effective and well- tolerated therapies. Comprehensive analyses of the molecular changes that contribute to these conditions may lead to the development of such therapies.

PI_NAMEs: O'BRIEN, CHARLES A (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Affect;Animals;Arkansas;Biomedical Research;Centers of Research Excellence;Clinical Investigator;Collaborations;CRISPR interference;Degenerative polyarthritis;Development;disability;Disease;effective therapy;Environment;Functional disorder;Funding;Gene Expression Profiling;genetic manipulation;Health Care Costs;in vivo;Lead;loss of function;Malignant Breast Neoplasm;Malignant Neoplasms;Medical;Mentors;Molecular;Molecular Analysis;Multiple Myeloma;Musculoskeletal;Musculoskeletal Diseases;Musculoskeletal System;novel;novel strategies;Osteomyelitis;Osteoporosis;Patients;Phase;Pilot Projects;Productivity;programs;recruit;Research;Research Infrastructure;Research Personnel;Resources;Sampling;Science;Services;skeletal abnormality;Skeleton;Structure;success;synergism;Technology;Universities

PROJECT_TITLE: Center for Musculoskeletal Disease Research (CMDR)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Childhood Injury;Clinical Research;Microbiome;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Patients aged 65 and older account for an increasing portion of traumatic brain injury (TBI) patients while also suffering increased morbidity and mortality compared to young TBI patients. The interplay between microglia, infiltrating immune cells, and the gut is still unknown but connections between immune infiltration in the brain and poor neurologic outcomes after TBI have been made. We will use a model of microglial depletion and a fecal microbiota transfer (FMT) model to assess the impact of microglial activation and the gut on immune cell infiltration in the aged brain after TBI.

PI_NAMEs: SCHWULST, STEVEN J (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Adopted;aged;aging brain;Attenuated;Award;behavioral outcome;Brain;Brain Injuries;CD8-Positive T-Lymphocytes;Cells;Cessation of life;Clonal Expansion;Cognitive;fecal microbiota;Flow Cytometry;Future;Gene Expression;glial activation;gut microbiome;gut microbiota;human old age (65+);Immune;immune cell infiltrate;Immunology;improved;Infiltration;Inflammatory Infiltrate;Inflammatory Response;inhibitor;Injury;Journals;Leukocytes;Macrophage Colony-Stimulating Factor Receptor;Mediating;Microglia;Modeling;monocyte;Morbidity - disease rate;mortality;Mus;Neurocognitive;neurocognitive test;neuroimmunology;neuroinflammation;Neurological outcome;old mice;Outcome;Patients;Peer Review;Phenotype;Preparation;Proliferating;Publishing;recruit;Rodent;Route;single-cell RNA sequencing;Survivors;symposium;T-Cell Activation;T-Lymphocyte;TBI Patients;therapeutic development;Training;transcriptome sequencing;Trauma;Traumatic Brain Injury;Youth

PROJECT_TITLE: The Young Gut Microbiome: A Fountain of Youth for Brain Injury in the Aged?


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Lung;Pediatric;Rare Diseases

ORG_DEPT: PEDIATRICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE Stimulating heart muscle cell division is the holy grail of heart regeneration research. We will perform a clinical trial of β-blocker administration with the goal of increasing heart muscle cell division in infants with Tetralogy of Fallot, the most common form of cyanotic congenital heart disease. We will use a newly developed method to unequivocally quantify heart muscle cell division as primary outcome.

PI_NAMEs: KUHN, BERNHARD  (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: Academy;Adrenergic beta-Antagonists;Age Months;American;Arrhythmia;beta-adrenergic receptor;Birth;cardiac magnetic resonance imaging;Cardiac Myocytes;cardiac regeneration;Cardiac Surgery procedures;Cardiovascular Surgical Procedures;Cell division;Cell Proliferation;Characteristics;Child;Clinical;clinical center;Clinical Trials;cohort;Congenital Abnormality;congenital heart abnormality;Cyanotic heart disease;Data;Development;Diagnosis;Diagnostic;DNA;Double-Blind Method;Drug Kinetics;Echocardiography;editorial;experience;follow-up;Foundations;Future;Generations;Goals;Growth;Guidelines;Health;Heart;Heart failure;Heart Hypertrophy;Human;Hypertension;Hypertrophy;Hypoplastic Left Heart Syndrome;improved;in vivo;infancy;Infant;Infant Mortality;innovation;Interruption;Investigation;Isotopes;Journals;Label;Long-Term Care;mass spectrometric imaging;Medicine;Methods;Molecular;Myocardial;Myocardium;neonatal mice;New England;novel;Operative Surgical Procedures;Outcome;Pathologic;Pathology;Patients;Pediatric Hospitals;Pediatrics;Persons;pharmacologic;Physiologic intraventricular pressure;Placebo Control;Placebos;postnatal;preclinical study;prevent;primary outcome;Proliferating;Propranolol;Protocols documentation;Publishing;Pulmonary Valve Stenosis;Randomized;randomized trial;Randomized, Controlled Trials;Receptor Signaling;recruit;Regenerative research;repaired;Research;Research Infrastructure;response;right ventricular failure;Right Ventricular Hypertrophy;right ventricular remodeling;Risk;Safety;Sampling;secondary outcome;Signal Transduction;skills;spelling;stable isotope;Strawberry nevus;success;Supraventricular tachycardia;Testing;Tetralogy of Fallot;Thoracic Surgical Procedures;Thymidine;Time;Ventricular;ventricular hypertrophy;Visit;Visualization;Work

PROJECT_TITLE: Mechanistic clinical trial of Beta-blocker administration for reactivating cardiomyocyte division in Tetralogy of Fallot

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Transcranial Magnetic Stimulation (TMS) is a noninvasive brain stimulation method with current FDA approvals for treatment of major depressive disorder (MDD) and obsessive-compulsive disorder (OCD) but most clinical applications are focused on single brain target. This project employee a novel multichannel TMS (mTMS) system specifically designed for multifocal brain network stimulation that can be used to enhance the connectivity between brain areas. When combining multifocal brain stimulation with electrical measurements of functional connectivity using electroencephalography (EEG), this technology can be used to optimize the network-level stimulation protocols paving way for improved therapeutic outcomes with minimized side effects and treatment duration in future.

PI_NAMEs: DANESHZAND, MOHAMMAD  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: active control;Address;Affect;Anatomy;Area;Brain;brain abnormalities;brain dysfunction;Clinical;clinical application;Computing Methodologies;Contralateral;Data;depressive symptoms;design;Development;Diffusion Magnetic Resonance Imaging;Distant;Drug resistance;electric field;electrical measurement;Electroencephalography;Elements;Employee;experience;experimental study;FDA approved;Frequencies;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Goals;Hand;Head;healthy volunteer;Hot Spot;Imaging Techniques;improved;Individual;Joints;Left;Link;Location;Magnetic Resonance Imaging;Major Depressive Disorder;Maps;Measures;Mental Depression;Mental disorders;Mental Health;Mentorship;Methods;Motor;Muscle;Network-based;Neurobiology;neuropsychiatric disorder;neuropsychiatric symptom;neuropsychiatry;noninvasive brain stimulation;novel;Obsessive-Compulsive Disorder;Outcome;Parietal Lobe;Pathogenesis;Patients;Prefrontal Cortex;prevent;Protocols documentation;recruit;Relapse;repetitive transcranial magnetic stimulation;Research;Resistance;Rest;Running;Sensory;Side;side effect;simulation;Site;Specificity;structural imaging;Symptoms;System;Technology;therapy outcome;tool;tractography;Training;Transcranial magnetic stimulation;treatment duration

PROJECT_TITLE: Probing network-specific cortical connectivity by combining multifocal transcranial magnetic stimulation with electroencephalography

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (91)]


NIH_SPENDING_CATS: Genetics;Hematology;Neurosciences

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: NARRATIVE How mechanical forces involve in human diseases is largely unknown. Our goal of this application is to create a mouse model carrying the most common disease-causing mutation of the force- sensing ion channel TMEM63B, to catalyze the understanding on the pathophysiological functions of this newly discovered force sensor in human health and disease.

PI_NAMEs: YANG, HUANGHE  (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Ablation;Address;Behavioral;Biological Assay;Blood Cells;blood pressure regulation;Breeding;Calcium Signaling;Cardiology;Cell Death;Cell membrane;cell motility;Cell Physiology;cell type;Cells;Characteristics;Chemicals;Clinical;Communities;Cytomegalovirus;deafness;Deposition;Development;Discipline;Disease;disease-causing mutation;Dissection;Droughts;Embryo;Ensure;Epilepsy;Erythrocytes;Evaluation;Evolution;Exhibits;experimental study;Family;force sensor;Foundations;Functional disorder;Future;gain of function;Generations;Genetic;Genomics;Genotype;Goals;Health;hearing impairment;Hematology;Human;human disease;Human Genetics;Human Pathology;In Vitro;in vivo;Intellectual functioning disability;Ion Channel;Ions;Knock-in Mouse;Knowledge;Laboratories;Light;lipid transport;Lipids;LoxP-flanked allele;mechanical force;Mechanics;Methodology;Minority;Mission;Modeling;mouse model;Mus;Muscle Contraction;Mutant Strains Mice;Mutate;Mutation;Nerve Degeneration;Neurobiology;Neurons;Nobel Prize;novel;Orthologous Gene;Osmosis;Outer Hair Cells;Patients;Phenotype;Phospholipids;Physiological;Piezo 1 ion channel;Piezo 2 ion channel;Plants;Play;Process;Proliferating;Property;Protein Family;Proteins;Regulation;Research Personnel;response;Role;Solid;Stimulus;Stress;Symptoms;Testing;The Jackson Laboratory;Therapeutic;Touch sensation;trait;United States National Institutes of Health;Validation;Variant

PROJECT_TITLE: Deciphering mechanobiology in human diseases by developing a TMEM63B channelopathy mouse model

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ORG_NAME: ARKANSAS STATE DEPARTMENT OF AGRICULTURE

PHR: 2 Project Narrative  Cooperative agreement between AVDL and FDA Vet-LIRN will strengthen the food safety  system by using AVDL's capacity and capabilities to analyze animal food or animal drug  samples that may be adulterated and investigate animal foodborne illness outbreaks.

PI_NAMEs: PULLA, SHARON  (contact)

PROJECT_TITLE: Participation in the FDA Vet-LIRN Cooperative Agreement Program to strengthen analysis of animal food or animal drug samples that may be adulterated and investigation of foodborne illness outbreaks.


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Not Applicable

PI_NAMEs: GALLETTO, ROBERTO  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: helicase;Regulation;Site;telomere

PROJECT_TITLE: Functions of DNA helicases at hard-to-replicate sites and telomere regulation


ADMINISTERING_IC: DC

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PURDUE UNIVERSITY

PHR: Project Narrative The number of successful researchers working in the area of deafness and other communication disorders is not sufficient to meet current needs. In addition, more diversity is needed in the pool of researcher. In this application for a supplement, we propose a training program designed to broaden the research skills of a diverse basic scientist to the study of communication disorders.

PI_NAMEs: STRICKLAND, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TITLE: Diversity Supplement


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: Project Narrative We develop the multiplexed super-resolution force spectroscopy to investigate the mechanism of ribosome translocation during protein synthesis. We will measure the power strokes from elongation factors and their mutants during ribosome translocation on modified mRNA sequences and in the presence of antibiotics. Our research will provide new model about the ribosome translocation with sub-codon steps and provide potential drug targets for the related diseases.

PI_NAMEs: WANG, YUHONG  (contact);XU, SHOUJUN

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Acoustics;Affect;Amino Acids;Antibiotic Resistance;Antibiotics;base;Binding;Biological Assay;biophysical tools;CAG repeat;Cardiovascular Diseases;Cells;Child;Codon Nucleotides;Congenital Epilepsy;Degenerative Disorder;design;Detection;Disease;disease-causing mutation;DNA Tumor Viruses;Drug Targeting;Elongation Factor;Epilepsy;Exons;Funding;G-Quartets;Generations;Grant;GTP Binding;Guanosine Triphosphate;Health;Homologous Gene;Human;human disease;Huntington Disease;Huntington gene;improved;insight;Intellectual functioning disability;Kinetics;Knowledge;Legal patent;Location;Maintenance;Malignant Neoplasms;Manuscripts;Measurement;Measures;mechanical force;Messenger RNA;Methods;Modeling;Modification;Movement;multiplex detection;Muscle;mutant;Mutation;Neurons;new technology;new therapeutic target;novel;Nucleotides;Outcome;Paper;Peptide Elongation Factor G;Peptides;Phase;Phosphorylation;Phosphotransferases;Play;Positioning Attribute;Power stroke;Process;Protein Biosynthesis;Radiation;Reading Frames;Regulation;Research;Resistance;Resolution;Ribosomal RNA;Ribosomes;RNA;Role;Sampling;Scheme;sensor;Side;Spectrum Analysis;Structure;Techniques;therapeutic target;Time;Transfer RNA;Translational Regulation;Translations;translocase;ultra high resolution;Virus Diseases

PROJECT_TITLE: A Novel Force Spectroscopy to Study the Ribosome Power Stroke and Frameshifting


ADMINISTERING_IC: CK

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

PHR: PROJECT NARRATIVE Healthcare-associated infections due to antibiotic resistant organisms are an extremely important cause of morbidity and mortality. We will use models and simulations to enhance our ability to respond to this threat in two major ways: by making infection control efforts more effective and efficient, and by guiding improvements in use of antibiotics

PI_NAMEs: SAMORE, MATTHEW H (contact)

PROJECT_TITLE: RFA-CK-20-003: Modeling and Simulation to Support Epidemiological Decision-Making in Healthcare Settings


ORG_CITY: Silver Spring

ORG_NAME: CENTER/ DISEASE DYNAMICS, ECONOM/POLICY

ORG_STATE: MD

PHR: Project Narrative The models developed through this proposal will improve understanding of how biological factors associated with the transmission of multidrug-resistant organisms (MDRO) impact interventions to reduce hospital-associated infections (HAIs). This will aid predictions of patients' risk for colonization and infection, as well as improve understanding of how interventions can most effectively be combined to reduce the likelihood that patients will suffer from these high-consequence pathogens.

PI_NAMEs: KLEIN, EILI YA'AKOV (contact)

PROJECT_TITLE: RFA-CK20-003: In silico Randomized Control Trial Framework for Assessing Infection Control and Prevention Interventions in the Hospital


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE We propose to use mathematical modeling, agent-based simulation and machine learning approaches to build decision-making technologies that improve the risk assessment, prevention and control of healthcare- associated infections and antibiotic-resistant infections. Our proposed technologies will account for spatial and temporal dynamics, provide continuous, real-time feedback to clinicians and are robust to changes in risk factors and disease prevalence over time. We concentrate our efforts on two of the most important healthcare- associated infections: methicillin-resistant Staphylococcus aureus and Clostridioides difficile infections.

PI_NAMEs: PORCO, TRAVIS CHRISTIAN (contact)

PROJECT_TITLE: RFA-CK20-003: Modeling of infectious network dynamics for surveillance, control and prevention enhancement (MINDSCAPE)


ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Healthcare-associated infections (HAIs) affect about two million patients in American hospitals each year. Of particular concern are multidrug resistant organisms (MDROs) that can be ampliﬁed in hospitals, transmitted to other hospitals, long-term or skilled-care facilities, and then, eventually, exported to the community at large. The goal of this project is to build high-ﬁdelity models of HAI transmission within and across healthcare facilities from large, complex, ﬁne-grained data sources. Simulations based on these models can be used to better understand the transmission of HAI pathogens, compare alternative infection control interventions, and provide effective and practical guidance on best practices to reduce the transmission of MDROs and other HAI pathogens.

PI_NAMEs: POLGREEN, PHILIP M.;SEGRE, ALBERTO MARIA (contact)

PROJECT_TITLE: RFA-CK20-003: Contact Network Transmission Modeling of Healthcare Associated Infections


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Infections by antimicrobial resistant (AR) pathogens are a persistent threat to human health in healthcare settings. Here, for this MInD Healthcare network project, we propose to use hospitalization records and diagnostic data for multiple AR pathogens from four major hospitals in New York City to conduct a series of modeling studies. Our aims are to: 1) model the spread of AR pathogens in healthcare systems at individual and facility levels; 2) infer key epidemiological parameters and asymptomatic carriage probabilities; 3) predict outbreaks of AR pathogens in healthcare facilities; 4) evaluate and optimize potential intervention measures; and 5) partner with other network modeling groups to test interventions across different models.

PI_NAMEs: PEI, SEN ;SHAMAN, JEFFREY L (contact)

PROJECT_TITLE: RFA-CK20-003: Analysis and Simulation of Bacterial Infections and Resource Strain in Hospitals during the COVID-19 Pandemic


ADMINISTERING_IC: GH

IC_NAME: Center for Global Health

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: NARRATIVE (ADMINISTRATIVE CORE) The Washington State University (WSU) and the Liverpool School of Tropical Medicine (LSTM) propose to use their collective administrative and technical experience in Kenya and excellent relationships with the Kenya Medical Research Institute (KEMRI) to support KEMRI in the management of the KEMRI/CGHR Research Platform (KRP), cost-effectively and sustainably. The platform includes the population-based health and demographic surveillance systems, laboratories, clinical research centers, offices, and shared services. Following extensive discussions with KEMRI that led to this joint application, we agreed to implement a highly cost-effective management plan that develops strong organizational capacities within KEMRI, which is required to assume successful and sustainable management of the KRP infrastructure in support of their public health research in Kenya. In addition, we demonstrate clear technical expertise to lead the Research Core areas identified in the RFA, using the same approach of twinning experienced WSU and LSTM scientists with KEMRI and CDC counterparts to design, implement, and publish finding from the studies, an approach designed to train and mentor KEMRI scientists in applying and managing research funding.

PI_NAMEs: NJENGA, M KARIUKI (contact)

PROJECT_TITLE: GH21-003, Advancing Public Health Research in Kenya


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: LOMA LINDA

ORG_NAME: VA LOMA LINDA HEALTHCARE SYSTEM

PHR: Principal Investigator: Hongzhe Li Narrative Project Title: Maximizing hearing recovery from peri-synaptic damage Narrative  Many Veterans suffer from noise-induced hearing loss (NIHL) due to exposure to high intensity sounds during their military service. Wounded soldiers and Veterans often receive critical lifesaving antibiotics to treat and prevent bacterial infections, which also put them at a high-risk for a drug-induced ototoxicity. Increasing evidences suggest substantial noise- and drug-induced hearing loss can include synaptopathy, which may be reversible, if treated on time. Thus, this type of neurological injuries has potentially significant implications for military Service Member performance, long-term received Veterans health, and noise exposure standards. The present study is designed to better understand cochlear synaptic damage and to investigate rehabilitative strategies to disrupt such neural degeneration. Study results will contribute to Veterans Health Administration’s (VHA’s) goal to help improve the quality of life of Veterans, who suffer from hearing loss due to noise damage and drug-induced ototoxicity.

PI_NAMEs: LI, HONGZHE  (contact)

PROJECT_TERMS: Acoustic Nerve;Acoustics;Adrenal Cortex Hormones;Affect;Aftercare;Aminoglycoside Antibiotics;Aminoglycosides;Animal Model;Animals;antagonist;Antibiotics;Antineoplastic Agents;Audiology;Auditory;Auditory Brainstem Responses;Auditory system;Bacterial Infections;Benchmarking;Body Weight;capsazepine;CBA/CaJ Mouse;cell injury;Cell Physiology;Cell Survival;Cessation of life;cigarette smoke;Cisplatin;Cochlea;cochlear synaptopathy;Cytoplasm;Data;density;design;Deterioration;Disease;dosage;Dose;effective intervention;Effectiveness;Electrophysiology (science);Elements;Environment;Exposure to;Frequencies;Gene Modified;gentamicin A;Gentamicins;Goals;Hair Cells;Health;Hearing;hearing impairment;high risk;Human;improved;Inflammation;Injections;injured;Inner Hair Cells;Investigation;Knockout Mice;Labyrinth;Life;Loudness;Measures;Methylprednisolone;Microscopy;Military Personnel;military service;Modeling;Modification;Molecular;Morphology;mouse model;Mouse Strains;Mus;Mutant Strains Mice;Nerve Degeneration;Nerve Fibers;Nervous System;Nervous System Trauma;neuronal survival;Neurons;neurotrophic factor;Noise;noise exposure;Noise-Induced Hearing Loss;otoacoustic emission;ototoxicity;Outcome;Outcome Study;Outer Hair Cells;Pathologic;Performance;Personal Communication;Pharmaceutical Preparations;Play;Population;postsynaptic;presynaptic;prevent;Principal Investigator;Process;programs;Protocols documentation;Publishing;Quality of life;Recovery;rehabilitation strategy;Rehabilitation therapy;Research Proposals;Resistance;Risk;Role;Sensory Hair;service member;Signal Transduction;sound;Speech;spiral ganglion;Stress;Synapses;Testing;Therapeutic;Time;transmission process;TRPV1 gene;Variant;Veterans;Veterans Health Administration;Visualization;wounded soldier

PROJECT_TITLE: Maximizing Hearing Recovery from Peri-Synaptic Damage

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: KANSAS CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: The overarching goal of this study is to identify the relationship between Medicaid expansion, poverty, and rural-urban ethnoracial mortality disparities in the United States from 2011 to 2019 using large-scale restricted data and novel estimates of poverty. The project will use the state-by-state roll out of Medicaid expansion to evaluate the association between Medicaid expansion and rural-urban ethnoracial mortality disparities, as well as the mediating role of poverty in this relationship. The results of this study will provide essential information for future public health policy initiatives at the health care system-level, while also providing important evidence on the impact Medicaid expansion has, or has not had on poverty and mortality disparities in the United States.

PI_NAMEs: MUELLER, JOEL THOMAS (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Address;Adult;Affordable Care Act;American;Black race;Censuses;Community Surveys;County;Data;data centers;Death Rate;design;Disease;Disparity;Disparity population;disparity reduction;Drops;Economically Deprived Population;Ensure;ethnoracial;ethnoracial disparity;ethnoracial minority;federal poverty level;Future;Goals;health disparity populations;Health Policy;Health Services Research;Healthcare Systems;Hispanic;Household;improved;Income;innovation;interest;Knowledge;Living Costs;Measures;Mediating;Medicaid;Methods;minority health;minority health disparity;Minority Health Research;Mission;Modeling;mortality;mortality disparity;National Institute on Minority Health and Health Disparities;Not Hispanic or Latino;novel;Policies;Policy Analysis;population survey;Poverty;poverty alleviation;poverty reduction;Public Health;Reduce health disparities;Research;Role;Rural;rural disparities;Rural Population;rural poverty;rural underserved;social health determinants;socioeconomic disadvantage;System;Testing;Time;time use;Underserved Population;United States;Update;Urban Population;Variant;Vital Statistics

PROJECT_TITLE: The Effect of Medicaid Expansion on Mortality Disparities and Poverty

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Racial/ethnic minorities are disproportionately affected by breast cancer outcomes as Black and Hispanic women are 20% more likely than White women to be diagnosed with advanced stage breast cancer; and have up to 70% and 14% increased risk of death, respectively. This K01 project aims to identify areas of low mammography screening, and to elucidate the racial/ethnic specific barriers on the uptake of adequate mammography screening for Black and Hispanic women within the defined high-risk areas. The long-term goal of this research trajectory is to contribute to the reduction of racial and geographic disparities in breast cancer outcomes.

PI_NAMEs: MOORE, JUSTIN XAVIER (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Achievement;Address;advanced breast cancer;Affect;analytical method;Area;Award;Bayesian Analysis;Bayesian Method;Behavioral Risk Factor Surveillance System;Black Populations;Black race;black women;Breast;Breast Cancer Early Detection;Breast Cancer Risk Factor;Cancer Control;cancer epidemiology;cancer health disparity;cancer prevention;career development;Caring;Communities;community barrier;community based participatory research;County;Data;Development;Diagnosis;Disparity;Epidemiology;ethnic minority;Ethnic Origin;experience;follow-up;Foundations;Funding;geographic difference;geographic disparity;Goals;Grant;health communication;high risk;Hispanic;Hispanic Populations;Hispanic Women;Hot Spot;indexing;Individual;innovation;insight;Interdisciplinary Study;Intervention;Intervention Studies;Interview;Longitudinal Studies;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Maps;Mentors;Methodology;Methods;Minority;Minority Women;mortality;mortality risk;multidisciplinary;National Health Interview Survey;novel;Outcome;Patient Recruitments;Pattern;Pilot Projects;Population;Prevalence;Public Health;Publications;Publishing;Race;racial difference;racial disparity;racial minority;Racial Segregation;recruit;Reporting;Research;Research Activity;research and development;Research Design;Research Methodology;Research Personnel;Resources;Risk;Sampling;screening;social epidemiology;social health determinants;Socioeconomic Factors;spatial epidemiology;Structure;Surveys;Training;United States;United States National Institutes of Health;uptake;White Women;Woman;Work

PROJECT_TITLE: Geographic and Racial Disparities in Mammography Screening and Barriers to Receiving Care


ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE This project will examine the mechanisms that enable beneficial symbionts to colonize and be maintained by a host, such as the ability to eliminate competitors and grow within host niches. The insights into these mechanisms that are gained by this research may promote new strategies for harnessing beneficial symbionts as therapeutics to improve human health.

PI_NAMEs: MIYASHIRO, TIMOTHY  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Molecular determinants of bacterial interactions and maintenance in the Vibrio fischeri-Euprymna scolopes symbiosis


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Depression;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Social connection during pregnancy is a well-established buffer for prenatal stress known to predict better infant and maternal health in the postpartum period. This study examines how social disruption, particularly during the COVID-19 pandemic, affects expectant parents and their subsequent mental health, birth outcomes, and infant development.

PI_NAMEs: SAXBE, DARBY E. (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Affect;Age;Anxiety;Anxiety Disorders;anxiety symptoms;Apgar Score;Behavior;Behavioral;biopsychosocial factor;Birth;Birth Weight;Buffers;Child;Child Health;Child Rearing;Childbirth;cohort;Communities;Coronavirus;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Reporting;Data Set;depressive symptoms;Development;Disease;Distress;Economics;Enrollment;Expectancy;experience;Extended Family;Family health status;Fathers;Feeling;Fetal Development;follow-up;Foundations;Fright;Funding;Geographic Locations;Gestational Age;Guidelines;Hair;Health;healthy pregnancy;Height;Hospitals;Hydrocortisone;in utero;Incidence;indexing;Infant;Infant Development;Infant Health;infant temperament;Infection;insight;Knowledge;Link;Location;Loneliness;Long-Term Effects;Low Birth Weight Infant;Maternal Health;Measures;Mental Depression;Mental Health;Modeling;Mood Disorders;Mothers;National Institute of Child Health and Human Development;Natural experiment;neurodevelopment;neuroimaging;Neurosecretory Systems;Outcome;pandemic disease;pandemic impact;Parents;Participant;Patient Self-Report;perceived stress;Personal Satisfaction;Persons;Population;postpartum outcome;Postpartum Period;pre-pandemic;Pregnancy;Pregnant Women;Premature Birth;prenatal;Prenatal care;prenatal stress;protective factors;psychological distress;Readiness;Recovery;recruit;Reporting;Research;resilience;Risk;Risk Factors;Sampling;Schools;Shapes;social;Social Behavior;Social Distance;social factors;Social support;Source;stay-at-home order;Strategic Planning;Stress;stress management;stressor;Temperament;Testing;United States;Woman

PROJECT_TITLE: Prenatal Social Connection and Disruption During the COVID-19 Pandemic: Effects on Maternal and Infant Health


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PI_NAMEs: LYUBIMOV, ALEXANDER V (contact)

PROJECT_TERMS: Animal Experiments;Area;Contracts;Development;Evaluation;Malignant Neoplasms;meetings;Mutagenicity Tests;Oryctolagus cuniculus;pharmacologic;Pharmacology and Toxicology;pre-clinical;Preventive;programs;reproductive;Resources;Rodent;Testing;Toxic effect;Toxicology

PROJECT_TITLE: Contract Orientation and Kickoff Meeting


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Social Determinants of Health

ORG_CITY: Arlington

ORG_NAME: POTLUCK, LLC

ORG_STATE: VA

PHR: PROJECT NARRATIVE This research and product development delivers a rigorously designed and tested social engagement technology (OneClick) with online games tailored to the needs, abilities, and interests of older adults with and without Mild Cognitive Impairment (MCI). The online games will be well-known and enjoyable to older adults, and facilitate and enhance social interaction between older adults with and without MCI and their close friends and family members. The games will make it easy for people to connect, thereby stimulating social interaction and engagement, which is beneficial to health and quality-of-life outcomes.

PI_NAMEs: GANDY COLEMAN, MARIBETH ;MYERS, DILLON  (contact);VICKERS, KAYCI

PROGRAM_OFFICER_NAME: PLUDE, DANA JEFFREY

PROJECT_TERMS: Adult;Affect;Age;Aging;Alzheimer's Disease;brain health;Code;Cognitive;cognitive function;Collaborations;commercialization;Communities;comparison group;computer science;Control Groups;Dementia;design;Development;efficacy testing;Ensure;experience;Family;Family member;Friends;Funding;Goals;group intervention;Health;Health Benefit;Impaired cognition;implementation protocol;improved;Independent Living;industry partner;innovation;interest;Intervention;Intuition;Learning;Loneliness;Manuals;Marketing;Measurement;Methods;mild cognitive impairment;new technology;Observational Study;older adult;Outcome;Outcome Measure;Participant;Persons;Phase;Philadelphia;pilot test;Play;Preparation;product development;prototype;Quality of life;Randomized;Randomized, Controlled Trials;Readiness;Research;research and development;research study;Risk;Scheme;Services;Small Business Innovation Research Grant;social;social engagement;Social Interaction;Social isolation;Social Perception;Social support;Socialization;Standardization;Stress;Technology;Testing;Therapeutic;Time;Training;Treatment Efficacy;Universities;Update;usability;video chat;Waiting Lists;Work

PROJECT_TITLE: Enhancing Social Engagement through Online Gameplay for Older Adults with and without Mild Cognitive Impairment


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pain Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: KINGSTON

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE Pervasive race and gender disparities in the provision of healthcare are well-documented among those suffering from pain. The proposed project aims to identify patterns in medical student race and gender biases in pain assessment (inclusive of gender diverse patients) and how these biases impact treatment decisions and care. Findings will identify opportunities to tailor and implement effective intervention approaches aimed to reduce pain assessment biases among medical students with the goal to reduce future pain treatment disparities.

PI_NAMEs: RUBEN, MOLLIE  (contact)

PROJECT_TERMS: Address;Affect;Analgesics;Authorization documentation;Award;Caring;cis-female;cis-male;clinical pain;Code;Color;Communication;communication behavior;Communities;Data;Disparity;Economic Burden;Educational workshop;effective intervention;Environment;Equity;evidence base;Exhibits;experience;explicit bias;Future;gaze;Gender;gender disparity;gender diverse;gender minority;Goals;Health Disparities Research;health disparity;Health Services;Healthcare;Healthcare Systems;implementation science;Implicit Association Test;implicit bias;Inequity;innovation;intersectionality;Intervention;Knowledge;Laboratories;Leadership;maltreatment;marginalization;Mediation;Medical Education;medical examination;Medical Students;men;Mentored Research Scientist Development Award;Methods;minority health;minority health disparity;National Institute on Minority Health and Health Disparities;next generation;non-verbal;nonbinary;Nonverbal Communication;online version;Outcome;Pain;Pain management;Pain Measurement;pain reduction;Pain Research;Participant;Patient Self-Report;patient-clinician communication;Patients;Pattern;people of color;Persons;Physiological;Prejudice;Procedures;programs;Provider;psychologic;Publishing;Race;racial bias;racial disparity;racial diversity;racism;recruit;Reporting;Research;Research Personnel;Rhode Island;Science;Scientist;Sex Bias;Sexism;simulation;skills;Smiling;social;social culture;social stigma;Societies;Standardization;Strategic Planning;Students;Surveys;symposium;Testing;Time;Training;transgender;transgender men;transgender women;translational study;transphobia;treatment disparity;Universities;verbal;Videotape;Woman;women of color;Women's study;Work;young adult

PROJECT_TITLE: Dismantling barriers in pain management through an intersectional multi-method examination of race and gender biases


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Sleep Research

ORG_CITY: TROY

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

ORG_STATE: NY

PHR: Project Narrative:  The internal body clock, our circadian rhythms, control a broad range of processes in humans, timing our sleep cycles, metabolism, the immune response, and many other physiological functions to be optimally coordinated with our persistent day/night cycle. Due to the widespread integration of circadian control over many essential biological processes, the disruption of circadian rhythms has been linked to numerous medical conditions, including chronic inflammation, metabolic disease, and cancer, making an appreciation of clock control over physiology vital to human health research. Given the strong functional conservation between fungal, murine, and human clocks, our investigation of the fundamental mechanisms of intrinsically disordered proteins and their effects of circadian post-transcriptional regulation in mice and fungi will broaden the understanding of circadian regulation over human physiology, paving the way for the development of effective chronotherapeutics.

PI_NAMEs: HURLEY, JENNIFER MARIE (contact)

PROGRAM_OFFICER_NAME: SESMA, MICHAEL A

PROJECT_TERMS: Address;arm;Binding;Binding Proteins;Biological Clocks;Biological Models;Biological Process;Cell Physiology;Chronic;circadian;Circadian Dysregulation;circadian regulation;Circadian Rhythms;Complex;cost effective;Development;Disease;Ensure;Feedback;fitness;flexibility;Funding;fungus;Gene Expression;Genetic Transcription;Goals;Grant;Health;Hour;Human;Immune;Immune response;Inflammation;Investigation;Link;Macromolecular Complexes;Macrophage;Malignant Neoplasms;Mammals;Maps;Medical;Messenger RNA;Metabolic Diseases;Metabolism;Microscope;Microscopy;Molecular Conformation;Multiprotein Complexes;Mus;Output;Periodicity;Physiological;Physiology;Post-Transcriptional Regulation;posttranscriptional;Process;protein complex;Proteins;Research;sex;Sleep;Testing;Time;Translations;Vision

PROJECT_TITLE: Investigating Circadian Post-Transcriptional Regulation using Widefield Microscopy.


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Generalized anxiety disorder (GAD), the most prevalent anxiety disorder in primary care, is often misdiagnosed, particularly in individuals from marginalized sociodemographic groups. The proposed study leverages large- scale, epidemiologic and electronic health record datasets to evaluate two potential contributors to GAD diagnostic disparities: 1) psychometric bias, or indications that GAD’s diagnostic criteria fail to capture the same construct across sociodemographic groups or over time, and 2) disparities in patient-centered care, which is characterized by collaborative decision-making and respecting patients’ values, culture, and context. Findings from the proposed study will inform efforts to achieve equitable GAD diagnostic practices and treatment access by illuminating how minoritized groups experience GAD and how it can be accurately diagnosed.

PI_NAMEs: KINNEY, KERRY  (contact)

PROJECT_TERMS: Academic Medical Centers;access disparities;accurate diagnosis;Address;Adult;Alcohols;Anxiety Disorders;Asian population;base;Big Data;biological adaptation to stress;biomedical informatics;Black Populations;career;career development;Caring;Child Welfare;Chronic;Data;Data Set;Decision Making;Diagnosis;Diagnostic;diagnostic criteria;Disparity;Disparity in diagnosis;disparity reduction;economic cost;Economics;Education;Electronic Health Record;Emotions;Environment;epidemiologic data;Epidemiology;epidemiology study;Equity;Ethics;Ethnic Origin;Ethnic Population;Exhibits;experience;Extramural Activities;Family;Food;Funding;Future;Generalized Anxiety Disorder;Goals;Grant;health data;Health Disparities Research;health disparity;health equity;Health Services;Health Services Accessibility;Hispanic Populations;Housing;improved;Income;Individual;Inequality;innovation;insight;Intervention;Language;Link;low socioeconomic status;marginalization;marginalized population;Measurement;Measures;Mentored Research Scientist Development Award;Mentors;Methods;Minority Groups;Mission;Modeling;multidisciplinary;National Institute on Minority Health and Health Disparities;Natural Language Processing;novel;Patient-Centered Care;Patients;Prevalence;Primary Care;primary care setting;programs;Provider;Psychiatric Diagnosis;Psychiatric epidemiology;Psychometrics;Psychopathology;Qualifying;Race;racial minority population;racial population;Reporting;Research;Resources;Role;Sampling;skills;social health determinants;societal costs;sociodemographic factors;sociodemographic group;Socioeconomic Status;socioeconomics;Source;Stress;Surveys;Symptoms;Testing;Theoretical model;Time;Training;treatment of anxiety disorders;Uncertainty;Universities;Writing

PROJECT_TITLE: Delineating Sources of Racial, Ethnic, and Socioeconomic Differences in the Diagnosis of Generalized Anxiety Disorder


ADMINISTERING_IC: AI

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative: Development of a successful HIV vaccine is a grand challenge of modern vaccine science. Recently, the concept of shepherding the immune response toward protective B cell responses through a series of repeated immunizations has shown promise, but many fundamental questions about how such sequential immunization vaccines should be designed and optimized remain unanswered. In this proposal, we aim to develop several parallel practical approaches to enhance the ability of sequential immunizations to drive the development of broadly neutralizing antibodies that have the potential to be protective against HIV infection.

PI_NAMEs: CROTTY, SHANE P;IRVINE, DARRELL J (contact)

PROGRAM_OFFICER_NAME: MALASPINA, ANGELA

PROJECT_TERMS: Acceleration;Adjuvant;adoptive B cell transfer;Animal Model;Antibody Response;Antigens;B-Cell Development;B-Lymphocytes;Binding Sites;chemotherapy;Clinical;cost;Data;design;Development;Epitopes;Germ Lines;HIV;HIV immunization;HIV Infections;HIV vaccine;Human;Immune response;Immunization;Immunize;immunoengineering;Immunoglobulin Somatic Hypermutation;Immunologics;Immunology;improved;Injections;Kinetics;Knock-in;Knock-out;Malignant Neoplasms;Memory B-Lymphocyte;memory CD4 T lymphocyte;Modernization;mouse model;Mus;Mutation;neutralizing antibody;nonhuman primate;novel;novel strategies;Peptides;Phase;Physiological;pragmatic implementation;preclinical study;Process;Production;recruit;Regimen;response;RNA;RNA vaccine;Role;Science;Series;Specificity;structural biology;Structure of germinal center of lymph node;System;T-Lymphocyte;Technology;Testing;Vaccination;vaccination strategy;vaccine delivery;vaccine development;vaccine strategy;Vaccines;Work

PROJECT_TITLE: Immune engineering of optimized sequential immunization strategies for HIV vaccines


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: BOZEMAN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: PROJECT NARRATIVE The manipulation of a subset of glutamate-octopamine dual transmitting neurons results in increased levels of high intensity aggression. The goal of our study is to understand how dual transmission is regulated and how the release of two transmitters from the same neuron leads to changes in aggressive behaviors. A better understanding of the mechanisms by which dual transmission is controlled may lead to novel strategies to treat elevated aggression that are associated with psychiatric disorders or neurodegenerative diseases.

PI_NAMEs: CERTEL, SARAH J;KAUN, KARLA R.;STOWERS, STEVE  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;Adrenergic Receptor;age related changes;Aggressive behavior;analog;Antibodies;Biosensor;Cues;Economic Burden;Epitopes;Equilibrium;Exhibits;Functional Imaging;Funding;Genetic;Glutamates;Goals;Human;Image;insight;Invertebrates;Mental disorders;Molecular;monoamine;Neurodegenerative Disorders;Neurons;Neurosciences;neurotransmission;neurotransmitter release;Norepinephrine;novel strategies;Octopamine;Phenotype;Physiological;postsynaptic neurons;Regulation;Reproductive Behavior;Role;sexual dimorphism;Signal Transduction;Social Behavior;Societies;System;Testing;Therapeutic;tool;transmission process;Visualization

PROJECT_TITLE: Functional role of dual neurotransmission in aggression