NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Palliative Care;Prevention;Telehealth

PHR: Public health relevance: Symptoms during cancer treatment are common, compromise patient quality of life and ability to tolerate treatment, and often go undetected at clinic visits. This project aims to combine smartphone and wearable sensor data with machine learning to remotely monitor symptoms during chemotherapy and to develop a system that automatically recommends patient-provider contact when severe symptoms are detected.

PI_NAMEs: LOW, CARISSA A (contact)

PROGRAM_OFFICER_NAME: DIVI, RAO L

PROJECT_TERMS: acceptability and feasibility;Address;arm;Award;Behavior;Behavioral;cancer care;cancer therapy;care delivery;care outcomes;Cellular Phone;chemotherapy;Chemotherapy-Oncologic Procedure;Classification;Clinic;Clinic Visits;Clinical;clinically actionable;clinically significant;common treatment;Communication;Computer Models;Coupled;Data;design;Detection;Devices;digital health;Early Diagnosis;Enrollment;falls;feasibility testing;Fostering;Goals;Grant;Health Status;Heart Rate;Impairment;improved;Infrastructure;Instruction;Intervention;Life;Light;Location;Machine Learning;machine learning method;machine learning model;Medical;mobile computing;mobile sensing;mobile sensor;Modeling;Monitor;Noise;Notification;novel;Oncology;Outcome;parent grant;Parents;Participant;Patient Monitoring;patient oriented;patient-clinician communication;patient-provider contact;Patients;Pattern;Phase;Physical activity;Population;predictive modeling;prospective;Prospective, cohort study;Provider;public health relevance;Quality of life;Recommendation;remote monitoring;Reporting;Research;Running;Secure;sedentary lifestyle;sensor;Severities;Sleep;Sleep disturbances;Support System;Symptom Burden;symptom management;Symptoms;System;Telephone;Time;Toxic effect;Trust;wearable data;wearable device;wearable sensor technology;web app;Work

PROJECT_TITLE: A mobile sensing system to monitor symptoms during chemotherapy


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Characterization of the immune response before, during, and after administration of immunotherapy would allow researchers and clinicians to better understand how patients respond to these therapies and how resistance develops, as well as facilitate more informed decisions about therapy choice, dose, and target. One important marker of the immune response against cancer is the presence of mutated neoantigens in tumors, but a major unmet challenge is the ability to detect immune responses to neoantigens within tumors or in the peripheral blood. The proposed research seeks to apply a novel hydrogel-based platform for high throughput detection and expansion of neoantigen-specific immune responses in tumor- bearing mice and humans.

PI_NAMEs: SCHNECK, JONATHAN P (contact)

PROGRAM_OFFICER_NAME: CHUAQUI, RODRIGO F

PROJECT_TERMS: Adoptive Cell Transfers;Affect;Affinity;antigen binding;antigen-specific T cells;Antigens;Artificial nanoparticles;Biochemical;Blood;Blood Cells;burden of illness;cancer immunotherapy;Cancer Patient;CAR T cell therapy;CD28 gene;CD3 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Adhesion Molecules;cell mediated immune response;Cells;Clinical;Collagen;cost;Cues;cytokine;Data;Dendritic Cells;density;design;Detection;detection platform;Development;Disease;Dose;effector T cell;Encapsulated;Environment;experimental study;Gel;Gold;Health;HLA A*0201 antigen;Human;Hyaluronic Acid;Hydrogels;IL7 gene;Immune;immune checkpoint blockade;Immune response;Immunologic Markers;Immunotherapy;improved;Individual;Interleukin-10;Interleukin-15;Interleukin-2;Investigation;Laminin;machine learning model;Malignant Neoplasms;mathematical model;Melanoma;Melanoma patient;Memory;Methods;migration;Modeling;mouse model;Mus;Mutate;Mutation;neoantigens;new technology;novel;Outcome;Output;particle;Patients;Peptide/MHC Complex;peripheral blood;Phenotype;Population;pre-clinical;prevent;Process;Property;Protocols documentation;PTEN gene;Research;Research Personnel;Resistance;Resistance development;response;response biomarker;Safety;Signal Transduction;SILV gene;Splenocyte;success;System;T cell response;T-Lymphocyte;targeted treatment;Technology;technology development;Testing;Therapeutic;Time;TNFSF4 gene;tumor;Tumor Antigens;Tumor Expansion;tumor specificity;Viral;Work

PROJECT_TITLE: Identification of cancer neoepitope-specific T cells using novel high-throughput hydrogel based platforms

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-5 (O2)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: NARRATIVE Public Health Relevance: The limited intrinsic regenerative potential of large craniofacial bone defects represents a considerable challenge in oral and maxillofacial surgery. The long-term goal of this proposal is to develop novel tissue engineering platforms where mesenchymal stem cells (MSCs) with functional organic cation transporters belonging to the solute carrier 22A gene family can be encapsulated within tunable metformin-releasing injectable scaffolds to potentiate regeneration of vascularized critical-sized bone defects. We anticipate this innovative project will lead to broader metformin-releasing tissue engineering platforms to benefit many patients in need of oral, craniofacial as well as orthopedic bone regenerative procedures.

PI_NAMEs: SCHNEIDER, ABRAHAM  (contact);XU, HUAKUN

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Alginates;Anti-diabetic Drugs;Biguanides;Biocompatible Materials;Biological;Biopolymers;Blood capillaries;bone;bone marrow mesenchymal stem cell;Bone Regeneration;bone scaffold;Bone Tissue;calcium phosphate;Capillary Endothelial Cell;Cell membrane;Cell Survival;Cell Transplantation;Cells;Cellular biology;Cementation;Chemosensitization;Chitosan;Clinical;clinically relevant;controlled release;cost;craniofacial;craniofacial bone;Data;Defect;Dental Pulp;dental transplantation;Dose;Encapsulated;End Point Assay;Endothelial Cells;FDA approved;Fiber;Fibrin;Formulation;Gene Family;genetic approach;Goals;Human;Hydrogels;hydrophilicity;immunodeficiency;improved;In Vitro;in vivo regeneration;Individual;Infection;Injectable;innovation;Mandible;Mesenchymal Differentiation;Mesenchymal Stem Cells;Metformin;Minerals;Modeling;Molecular Biology;Natural regeneration;Neoplasms;neovascularization;novel;Operative Surgical Procedures;Oral;oral surgery specialty;Oral Surgical Procedures;Organic Cation Transporter;Orthopedic Procedures;Orthopedics;osteoblast differentiation;osteogenic;paracrine;Patients;Pharmaceutical Preparations;pharmacologic;postnatal;pre-clinical;preclinical study;Procedures;protein expression;Proteins;public health relevance;Rattus;regeneration potential;regenerative;regenerative tissue;Reporting;response;Role;scaffold;Science;solute;Source;stem cells;Testing;Therapeutic;Tissue Engineering;tissue regeneration;Tissues;Transplantation;Trauma;Tube;uptake;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Vascularization;Work

PROJECT_TITLE: Novel tunable metformin-releasing injectable scaffolds to enhance dental pulp stem cell-based craniofacial bone regeneration

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Heart Disease;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Patients undergoing extracorporeal membrane oxygenation (ECMO) are at signiﬁcant risk of brain injury, yet no neuromonitoring is performed due to limitations of current devices. We propose to predict the severity of brain injury in patients undergoing ECMO using complementary multi-modal neuromonitoring devices based on hemodynamic and electrophysiological parameters, probing cerebral autoregulation, neurovascular coupling, and neuronal health. This approach will ultimately provide a means to monitor the risk of brain injury in critically-ill patients and optimize personalized treatments.

PI_NAMEs: CHOE, REGINE  (contact);KHAN, IMAD RASHID

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Acute;Adult;Biometry;Blood;Blood flow;Blood Vessels;Brain;Brain Hypoxia-Ischemia;Brain Injuries;Brain region;Brain Stem;Cardiac;Cardiac Surgery procedures;Categories;Cell Nucleus;cerebral autoregulation;Cerebrovascular Circulation;Cerebrum;Coma;Control Groups;cost;Critical Care;Critical Illness;Devices;Diffuse;Disease;Electroencephalography;Electrophysiology (science);Evoked Potentials;Exhibits;Extracorporeal Membrane Oxygenation;Foundations;Frequencies;Functional disorder;functional outcomes;Future;Gases;Goals;Health;Heart Arrest;Heart failure;Heart Injuries;hemodynamics;Hospitalization;improved;Individual;individualized medicine;Injury;innovation;insight;instrument;Intensive Care;Intervention;Investigation;Life;Logistic Regressions;lung failure;lung injury;Machine Learning;Measurement;Measures;Midbrain structure;Modality;Monitor;Multicenter Trials;multimodality;Near-Infrared Spectroscopy;Nervous System Disorder;Nervous System Trauma;neuroimaging;Neurologic;Neurology;Neuronal Dysfunction;Neurons;neuroprotection;neurovascular coupling;non-invasive monitor;Optics;Outcome;outcome prediction;Oxygen;Patient-Focused Outcomes;Patients;Performance;personalized medicine;Physiology;predictive modeling;prevent;Procedures;Radiology Specialty;Receiver Operating Characteristics;Regulation;Research;Risk;Severities;Spectrum Analysis;System;Techniques;Technology;Testing;tool;treatment optimization;Work

PROJECT_TITLE: Non-Invasive Multi-Modal Neuromonitoring in Adults Undergoing Extracorporeal Membrane Oxygenation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on elucidating the mechanisms that are responsible for disease progression in patients treated with radiotherapy. In addition, our work aims to develop new combination therapies for the treatment of lethal advanced cancers. Therefore, the proposed study is relevant to the part of the NIH’s mission that pertains to improving health, prolonging life and reducing illness.

PI_NAMEs: LUCIEN-MATTEONI, FABRICE  (contact)

PROGRAM_OFFICER_NAME: ARYANKALAYIL, MOLYKUTTY J

PROJECT_TERMS: Abscopal effect;Address;Advanced Malignant Neoplasm;anti-tumor immune response;Antibodies;Antigen Presentation;Binding;Biology;Biotinylation;Birds;Blocking Antibodies;CD276 gene;CD8-Positive T-Lymphocytes;Cell Physiology;Cell-Mediated Cytolysis;Cells;Clinic;Clinical;combinatorial;cytokine;cytotoxic;cytotoxic CD8 T cells;Development;Disease Progression;Disseminated Malignant Neoplasm;Distant;Dose;extracellular vesicles;fluorescence imaging;Functional disorder;Genetic Engineering;Genetically Engineered Mouse;Goals;Health;humanized mouse;Image;Immune;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immune Evasion;Immunocompetent;immunogenic cell death;immunoregulation;Immunosuppression;Immunotherapy;Impairment;improved;in vivo;inhibitor;Ionizing radiation;irradiation;Knowledge;Label;Life;Malignant Neoplasms;Mediating;Mediator;Metalloproteases;Minority;Mission;MMP14 gene;Modeling;Molecular;mouse model;multidisciplinary;Mus;Neoplasm Metastasis;neoplastic cell;new combination therapies;Oncology;Outcome;Patient-Focused Outcomes;Patients;Peripheral;Physiology;pleiotropism;Pre-Clinical Model;prevent;Proteomics;Public Health;Radiation Oncology;Radiation therapy;Refractory;refractory cancer;Research;response;Risk;Role;Safety;screening;Signal Transduction;success;Surface;synergism;T-Lymphocyte;Technology;Testing;TGF Beta Signaling Pathway;Therapeutic;therapeutic target;therapeutically effective;Touch sensation;Toxic effect;Transforming Growth Factor beta;Translations;Treatment Efficacy;tumor;Tumor Antigens;Tumor Escape;Tumor Expansion;Tumor Immunity;tumor immunology;tumor progression;Tumor-Derived;United States National Institutes of Health;Work

PROJECT_TITLE: Overcoming tumor-intrinsic mechanisms of immune evasion to boost systemic response to radiotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 TIR-W (01)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative We propose to develop the Graph Artificial Intelligence for Precision identification of Alcohol use disorder (GAIPA), an evidence-driven, graph-based clinical informatics approach to transfer the knowledge learned from the AoU data to identify undiagnosed AUD cases in clinical care. The success of the proposed GAIPA model will provide a transferrable AUD classification model, bridge gaps between rich longitudinal EHR data and precision identification and management of AUD. This work will shift paradigms of big data and complex disease research, enabling EHR data to become part of daily AUD management.

PI_NAMEs: LIANGPUNSAKUL, SUTHAT ;SU, JING  (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Acute;Address;Adult;Affect;Alcohol consumption;alcohol risk;alcohol screening;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Pancreatitis;Artificial Intelligence;artificial intelligence model;Big Data;binge drinker;binge drinking;Cardiovascular Diseases;Caring;Cause of Death;Cessation of life;Chronic;Cirrhosis;Clinic Visits;Clinical;clinical care;Clinical Informatics;cohort;Complex;Computerized Medical Record;Consumption;COVID-19;COVID-19 pandemic;Data;data exchange;Data Set;Development;Diabetes Mellitus;Diagnosis;Disease;disease classification;Disease Management;disease model;drinking;Emergency Situation;Environmental Exposure;experience;Family;follow-up;Fright;gene environment interaction;Genetic;genome sequencing;genomic data;Genotype;Geography;Gold;Graph;Health;health care availability;Health Hazards;Health system;Heritability;high risk;hospital performance;Hospitals;Indiana;Individual;Knowledge;Learning;Life Style;low socioeconomic status;machine learning model;Malignant Neoplasms;Mental disorders;Mental Health;Minority Groups;Modeling;mortality risk;multimodal data;novel strategies;Outcome;Participant;Patient Care;Patients;Pattern;Phenotype;predictive modeling;Probability;Prospective Studies;Recording of previous events;recruit;Research;screening;Screening Result;social;social health determinants;statistical and machine learning;Stigmatization;success;Supervision;Surveys;System;Testing;Time;Training;trait;transfer learning;Treatment outcome;Universities;whole genome;Work

PROJECT_TITLE: GAIPA: Graph artificial intelligence for precision identification of alcohol use disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-A (50)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Rehabilitation;Stroke

ORG_DEPT: NEUROLOGY

PHR: Post-stroke language deficits are exceedingly common and can be devastating to social relationships, vocational success, and independence in activities such as shopping, banking, texting, and emailing. We will characterize how language deficits resolve or improve over the first year after left hemisphere stroke, by carrying out longitudinal language assessments and brain imaging. We aim to identify demographic, genetic, and imaging variables that predict improvement in discourse comprehension, reading, spelling through (1) restoration of blood flow to brain specific regions, (2) repurposing of healthy brain areas to take over functions of areas damaged by stroke, or (3) development of compensatory strategies.

PI_NAMEs: HILLIS, ARGYE E. (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Accident and Emergency department;Acute;acute stroke;Age;Alleles;Aphasia;aphasia recovery;aphasia rehabilitation;Area;Atrophic;Behavioral;Blood flow;Brain;brain dysfunction;brain health;Brain imaging;brain magnetic resonance imaging;Brain region;brain tissue;Brain-Derived Neurotrophic Factor;Characteristics;Clinical;Cognitive;cognitive process;Communication;Compensation;Complex;Comprehension;Cues;Data;Demographic Factors;Development;Education;Electronic Mail;experience;Eye Movements;Facial Expression;Fingerprint;functional decline;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Funding;Fusiform gyrus;Genetic;Genetic Polymorphism;Gestures;Goals;Image;Impairment;improved;Individual;Infarction;Inferior frontal gyrus;Injury;Internet;Intervention;Ischemia;Ischemic Stroke;Language;Language Disorders;Learning;Left;Lesion;lexical;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;meetings;Mission;Modality;Names;National Institute on Deafness and Other Communication Disorders;neural;neural network;Neuronal Plasticity;novel;organizational structure;Orthography;Patients;Performance;Perfusion;perfusion imaging;Persons;phonology;Population Heterogeneity;post stroke;Predictive Factor;Prognosis;Race;Reading;Recovery;Recovery of Function;Rehabilitation therapy;Reperfusion Therapy;Research;restoration;Retrieval;Selective Serotonin Reuptake Inhibitor;Serotonin Antagonists;social relationships;Societies;socioeconomics;Speech;spelling;Stroke;stroke-induced aphasia;structural imaging;Structure of supramarginal gyrus;Structure-Activity Relationship;success;Superior temporal gyrus;Testing;Text;Text Messaging;Time;Tissues;treatment strategy;Vocation;White Matter Hyperintensity;Writing

PROJECT_TITLE: Neural Basis of Language in Acute Stroke and Recovery

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Stomach Cancer

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Approximately 30% of all Americans are infected with Helicobacter pylori, a bacterium responsible for a range of gastric conditions, including ulcer, gastritis, atrophy, gastric intestinal metaplasia, and cancer, and yet significant knowledge gaps remain regarding how to best care for patients infected with this bacteria, and specifically how to integrate molecular information about strain into clinical care. Furthermore, host response to H. pylori also affects the outcome of the infection, and our preliminary data suggest that stress exposures such as adverse childhood experiences and low socioeconomic status may be associated with poor outcomes. We hypothesize that the combination of infection with virulent H. pylori strains and stress exposure synergistically contribute to the development of premalignant disease in the stomach.

PI_NAMEs: GARMAN, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Acids;Adaptive Immune System;Address;Adherence;adverse childhood events;Advocate;Affect;Alleles;American;Antibiotic Resistance;Antibiotics;Atrophic;Bacteria;Biological;biomarker identification;black patient;cancer risk;carcinoembryonic antigen-related cell adhesion molecules;Cells;chronic infection;Clarithromycin;Clinical;clinical care;clinical practice;clinically relevant;cohort;CXC Chemokines;Cytotoxin;Data;Data Reporting;Development;Diagnosis;Disease;Disease Progression;Disparity;effective therapy;Endoscopy;Ensure;Epithelium;ethnic minority;Event;Exposure to;Funding;Gastric Adenocarcinoma;gastric intestinal metaplasia;Gastric mucosa;gastric organoids;Gastric Tissue;Gastritis;Genes;Goals;Guidelines;health disparity;Helicobacter Infections;Helicobacter pylori;Heterogeneity;High Prevalence;high risk;high risk population;Histologic;IL8 gene;Immune Evasion;Immune response;improved;improved outcome;Incidence;Infection;Integration Host Factors;Intestinal Metaplasia;Investigation;Knowledge;Life Stress;Ligands;longitudinal analysis;low socioeconomic status;Malignant Neoplasms;malignant stomach neoplasm;Measurable;modifiable risk;Molecular;Morbidity - disease rate;Mucous Membrane;new therapeutic target;novel;novel diagnostics;novel strategies;Organoids;Outcome;outcome disparities;Patient Care;patient population;patient retention;Patients;personalized approach;Phenotype;Pilot Projects;precision medicine;premalignant;Premalignant Change;programs;progression risk;Prospective cohort;Quality of life;racial difference;racial diversity;racial minority;recruit;Refractory;Research;resistance allele;resistance gene;response;Retrospective cohort;Risk;Risk Factors;Risk Marker;Risk Reduction;risk stratification;Role;Sampling;screening;Series;Stomach;Stomach Diseases;Stress;stressor;surveillance strategy;Surveys;synergism;System;Testing;Time;Tissue Sample;Tissues;Treatment Failure;Ulcer;United States National Institutes of Health;Virulence;Virulence Factors;Virulent;Work

PROJECT_TITLE: IMAGINE: Intestinal Metaplasia And Gastritis INtErception Study

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: HD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Lung;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This project seeks to document the frequency and duration of diarrheal disease and acute respiratory infection in early childhood, and assess how intergenerational disadvantage and household and community circumstances shape disparities in children’s health, illness, and healthcare utilization. The results of this project will allow child health programs and health systems to better address health disparities in illness and healthcare utilization among young children, and inform our understanding of the consequences of intergenerational disadvantage for children globally.

PI_NAMEs: TRELEAVEN, EMILY  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: 5 year old;Acute;acute care;Acute respiratory infection;Address;Affect;Archives;Area;Asia;Attention;Behavior;burden of illness;care seeking;Caring;Cessation of life;Characteristics;Child;Child Health;Childhood;Communities;Country;Data;Diarrhea;diarrheal disease;Disadvantaged;Disease;Disparity;early childhood;economic disparity;Ethnic Origin;experience;Exposure to;Family;Family Study;Frequencies;General Population;Generations;Goals;Health;health care availability;Health care facility;health care quality;health care service;health care service utilization;health disparity;health equity;Health Personnel;Health Policy;Health Promotion;health service use;Health Services;Health Services Accessibility;Health system;health training;Healthcare;high risk;Household;immune health;improved;Incidence;Income;Individual;innovation;insight;intergenerational;Intervention;Life Cycle Stages;Literature;long-standing disparities;Longitudinal Studies;low socioeconomic status;Measures;Modification;Morbidity - disease rate;mortality;mortality risk;Neighborhoods;Nepal;Outcome;Parents;Pattern;Pneumonia;Policy Maker;programs;Provider;Race;Reduce health disparities;Research;Resources;respiratory;response;Role;Sampling;Shapes;social;social determinants;social disparities;social group;social health determinants;sociodemographics;socioeconomic disadvantage;Socioeconomic Status;stressor;structural determinants;Symptoms;Testing;Time;Training;United States;Vaccination;Water

PROJECT_TITLE: Intergenerational disadvantage and pediatric health disparities in acute respiratory illness and diarrhea

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: NARRATIVE Alzheimer’s Disease and Related Dementias (ADRD), set as a public health priority by the World Health Organization, is one of the leading causes of death in the U.S.; however, a dearth of ADRD research data that consider dynamics across racial/ethnic groups beyond minimum standard racial/ethnic categories is detrimental to understanding a comprehensive picture of the current state of ADRD and its future. Hybrid sampling (HybS) that combines address-based sampling and respondent driven sampling conducted through the push-to-Web method is an attractive and practical methodological option for yielding a probability sample for racial/ethnic minority data. This project aims 1) to establish an inclusive probability sample national survey panel of the general population of adults ages ≥ 40 years old with an oversample of Asian Americans focusing on the granular subgroups of Chinese, Asian Indian, Filipino, Korean and Vietnamese, and of Latinx stratified by Afro-heritage using the push-to-Web HybS and 2) to study ADRD risks across racial/ethnic groups and the role of social networks on ADRD risks.

PI_NAMEs: LEE, SUNG-HEE  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, JOHN

PROJECT_TERMS: Address;Adult;Age;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Asian;Asian Americans;Asian Indian;Behavior;Black Populations;brain health;Calibration;Caregivers;Categories;Cause of Death;Characteristics;Chinese;Cognition;Cognitive;Communities;cost;COVID-19 pandemic;Critical Illness;Data;Data Collection;data quality;dementia burden;dementia risk;Diagnosis;Dimensions;disability;Disparity;disparity reduction;Early Diagnosis;ethnic disparity;ethnic minority;Ethnic Origin;Ethnic Population;experience;Filipino;Future;General Population;Geography;Goals;Health;health disparity;Heterogeneity;human old age (65+);Hybrids;Impaired cognition;improved;Internet;Intervention;Interview;Korean American;Koreans;Language;Latinx;Life Experience;Link;Literature;Measures;Mediator;member;Mental Health;Methodology;Methods;middle age;Minority;minority disparity;Minority Groups;Minority Participation;modifiable risk;mortality;National Institute on Aging;older adult;Outcome;Outcome Study;Participant;Patient Recruitments;Patient Self-Report;Persons;Play;Policy Maker;Population;population based;pre-clinical;Prevalence;Prevention strategy;Probability Samples;Property;public health priorities;Race;racial disparity;racial minority;racial population;randomized trial;Regional Health Planning;Reporting;Research;Resources;Respondent;response;Risk;Risk Factors;Role;Sampling;social;social group;Social Network;Social status;social stigma;Subgroup;Surface;Surveys;Symptoms;System;Telephone;Testing;Time;tool;Vietnamese;World Health Organization

PROJECT_TITLE: Improving Inclusivity of Alzheimer’s Disease and Related Dementias Research for Asian Americans and Latinx through Nationally Representative Hybrid Sampling.

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: Cognitive deficits are a major determinant of the long-term disability associated with schizophrenia and other psychiatric disorders. Thus, an increased focus on developing novel therapeutic interventions targeting these deficits is highly warranted and important to the VA mission. Schizophrenia is associated with abnormal interactions between cortical regions. Thus, developing insights into circuit level changes that underlie the emergence of cognitive deficits represents an urgent challenge. Here we employ a multilevel, state of the art, approach to directly examine how basal forebrain modulation of cortical disinhibition helps to regulate functional network activity relevant to cognition. This work will inform novel therapeutic approaches to restore impaired network connectivity and cognition in schizophrenia and related disorders affecting veterans.

PI_NAMEs: MCNALLY, JAMES M (contact)

PROJECT_TERMS: Acute;Address;Affect;Anterior;Antipsychotic Agents;area striata;associated symptom;Attention;basal forebrain;Behavioral;Behavioral Paradigm;behavioral phenotyping;Brain;Brain region;cell type;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive performance;Communication;Coupling;Data;Detection;Disease;Disinhibition;Dorsal;effective therapy;Electrophysiology (science);Environment;Equilibrium;Etiology;executive function;experimental group;experimental study;Fiber;flexibility;Glutamates;Goals;hippocampal pyramidal neuron;Hippocampus;Home;Human;Impaired cognition;Impairment;in vivo;innovation;insight;Insula of Reil;Interneurons;Ketamine;Knockout Mice;Link;Long term disability;Measures;Mediating;Mental disorders;Mission;Modeling;Monitor;mouse model;multimodality;Mus;N-Methyl-D-Aspartate Receptors;neural;Neurobehavioral Manifestations;neurochemistry;neuromechanism;Neurons;neuropsychiatric disorder;neurotransmission;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;olfactory bulb;optogenetics;Output;Parvalbumins;Pathogenesis;Pathway interactions;Patients;Pattern;Performance;Pharmaceutical Preparations;Phase;Photometry;Physiological;Play;Population;Pre-Clinical Model;Process;Psychopathology;Psychoses;Publishing;Regulation;Research Design;restoration;Rodent;Role;Schizophrenia;serine racemase;Signal Transduction;Site;sustained attention;System;targeted treatment;Task Performances;Techniques;therapeutic development;translational model;Veterans;vigilance;Wakefulness;Work

PROJECT_TITLE: Basal forebrain regulation of default mode and task-on functional network activity: translational modeling of psychiatric disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 MHBA-N (01)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: The proposed work could impact public health in the short term by identifying receptor interacting protein kinase- 1 as a key driver of brain injury and neurological outcome in the chronic period after intracerebral hemorrhage. In the long term, the work will provide strong proof of concept that therapies based on inhibitors of receptor interacting kinase-1 given to patients with intracerebral hemorrhage well after their initial recovery could be trialed to mitigate or prevent neurological deficits and chronic blood-brain barrier damage.

PI_NAMEs: WHALEN, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acute;Adoptive Transfer;Alzheimer's Disease;Alzheimer's disease related dementia;Apoptosis;Automobile Driving;Biochemical;biological adaptation to stress;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Bone Marrow;Bone Marrow Cells;Brain;brain cell;brain endothelial cell;Brain hemorrhage;Brain Injuries;Cell Compartmentation;cell type;Cells;Cerebral endothelium;Cerebral hemisphere hemorrhage;Chimera organism;Chimerism;Chronic;Clinical Trials;Cognitive;Cognitive deficits;collagenase;cytokine;Data;Dementia;Dependence;Endothelium;Engineering;Flow Cytometry;Functional disorder;Hematoma;Hematopoietic;Human;Immune;immune activation;immune cell infiltrate;Impaired cognition;Inflammasome;Inflammatory;inhibitor;inhibitor therapy;Injury;Interleukin-1 beta;kinase inhibitor;Knock-in;Learning;lymph nodes;Mediating;Memory;Microglia;Modeling;Molecular;monocyte;Motor;motor deficit;Mus;Mutant Strains Mice;Mutation;Necrosis;Nerve Degeneration;Neurologic Deficit;Neurological outcome;neuron loss;Neurons;neurotransmission;novel;Pathogenesis;Patients;Peripheral;Persons;pharmacologic;Phase;Phosphorylation;Phosphotransferases;prevent;Process;Production;Protein Kinase Interaction;Protein-Serine-Threonine Kinases;Proteins;Public Health;receptor;Receptor-Interacting Protein;Recovery;repaired;Resolution;response;RIPK1 gene;Role;Serine;Signal Transduction;Spleen;Survivors;Synapses;synaptic function;Testing;therapeutic target;Up-Regulation;vascular cognitive impairment and dementia;Western Blotting;Wild Type Mouse;Work

PROJECT_TITLE: Targeting receptor interacting protein kinase-1 in the chronic period of intracerebral hemorrhage

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


FUNDING_MECHANISM: OTHERS

ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: Post-traumatic stress disorder (PTSD) afflicts many veterans and results in distress, disability, and suicide. PTSD is characterized by the inappropriate and/or excessive activity of defensive responses. Defensive responses are normally adaptive changes in physiology and behavior that maximize an organism’s safety when faced with a threat; however, excessive activation of defensive responses lead to maladaptive behaviors. This proposal aims to understand the brain physiology underlying defensive response by mapping and decoding the neurophysiological signals across multiple brain sites and the connections between these sites in response to multiple threat stimuli. Naïve animals are exposed to threat both before and after a traumatic social defeat stressor to determine how this stressor affects the responses to threat. Optogenetic manipulation of neural signals is used to modify behavior. The overall goal is to understand how the brain controls these behaviors and to find potential targets for intervention in the treatment of illnesses like PTSD.

PI_NAMEs: CHAN, AUBREY C (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Amygdaloid structure;Animal Behavior;Animal Testing;Animals;Asphyxia;awake;Back;Behavior;Behavior Control;behavior prediction;Behavioral;Behavioral Paradigm;Brain;brain control;Brain region;calmodulin-dependent protein kinase II;Carbon Dioxide;career;career development;Chronic;Cities;Clinical;clinical care;Communication;comorbidity;Complex;Comprehensive Health Care;Consult;Custom;Data;Dedications;Development;disability;Distress;Doctor of Philosophy;Dorsal;Electrodes;Emotional;Emotions;Ensure;Etiology;Exhibits;Exposure to;falls;fighting;follow-up;Foundations;foxes;Freezing;Fright;Future;Goals;graduate student;Halorhodopsins;Human;Human Resources;human subject;Implant;Individual;Inhalation;insight;Internal Medicine;Intervention;intervention refinement;Iowa;Knowledge;Lead;Link;maladaptive behavior;Maps;Measures;Medical center;Mental disorders;Mentors;Mentorship;Methods;midbrain central gray substance;military veteran;Modality;model organism;Modeling;Mus;neural;neuromechanism;Neurons;neurophysiology;neuroregulation;Neurosciences Research;neurosurgery;neurotransmission;novel;novel diagnostics;Odors;Optics;optogenetics;Organism;Outcome;Panic;Panic Disorder;Pathologic;Patients;Persons;Physicians;Physiological;Physiology;Post-Traumatic Stress Disorders;postoperative recovery;Principal Investigator;promoter;psychiatric inpatient;Psychiatric therapeutic procedure;Psychiatry;Research Technics;Respiration;response;Safety;Scientist;Services;Signal Transduction;Site;social defeat;Statistical Data Interpretation;Stimulus;Stress;stressor;Suicide;Techniques;temporal measurement;therapeutic target;Time;tool;Training;Translating;Translations;Veterans;Virus;Work

PROJECT_TITLE: Identification of Brain Circuits Underlying Fear and Panic


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Lung;Natural Products;Pulmonary Fibrosis;Rare Diseases

PHR: PROJECT NARRATIVE The current study seeks to investigate the mechanisms whereby a specific type of lung cell associated with idiopathic pulmonary fibrosis (IPF) accumulates and drives the pathology of this disease. To accomplish this, we have developed a new compound that selectively blocks the activation of a pathway that maintains these cells in the lung. Using cell-culture, and rodent models of IPF we will further test this pathway and assess how well this new compound could potentially treat IPF.

PI_NAMEs: HAAK, ANDREW JON (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: 3-Dimensional;Acute;Address;Affect;Age;age acceleration;Apoptosis;Benchmarking;Biochemical;Bleomycin;CDKN1A gene;Cell Culture Techniques;Cells;ChIP-seq;Chronic;Coculture Techniques;Collagen;Data;Deposition;design;Development;Disease;efficacy evaluation;Endothelium;Epithelial Cells;Epithelium;Event;Exhibits;experimental study;Fibroblasts;Fibrosis;flavanoid;Flavonoids;gain of function;Genetic Transcription;Host Defense;human data;idiopathic pulmonary fibrosis;improved;In Vitro;in vivo;in vivo bioluminescence imaging;indium-bleomycin;Induction of Apoptosis;inhibitor;injured;Injury;Interruption;Leukocytes;Link;loss of function;Luciferases;Lung;lung injury;Measures;Metabolism;Modeling;Molecular;Molecular Mechanisms of Action;Molecular Target;Monitor;Mus;NF-kappa B;nintedanib;novel;old mice;p65;Paracrine Communication;Pathology;Pathway interactions;Patients;pharmacologic;Phosphorylation;Phosphotransferases;Pirfenidone;Population;Proteomics;Pulmonary Fibrosis;Quercetin;Resistance;Resolution;response;Risk Factors;Rodent Model;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Signal Transduction;single-cell RNA sequencing;Slice;Testing;tool;transcriptome sequencing;treatment response

PROJECT_TITLE: Targeting Senescence Specific Mechanisms of NF-κB Activation to Reverse Chronic Pulmonary Fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-E (03)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_DEPT: GENETICS

PHR: Project Narrative This project will investigate why some Mycobacterium tuberculosis infections remain in the lung while others disseminate to other parts of the body. It will focus on one outbreak strain with a high rate of dissemination to bone. Using animal models, the project aims to understand how infecting bacteria escape the initial site of infection and subsequently cause damage in other organs and tissues, including bone.

PI_NAMEs: SMITH, CLARE MARGARET;TOBIN, DAVID M. (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Affect;Alleles;Animal Model;Animals;Bacteria;bacterial genetics;Behavior;Body part;bone;Bone Diseases;C3HeB/FeJ Mouse;causal variant;Cell Culture Techniques;cell motility;Cells;Cessation of life;chemokine;Clinical;clinical phenotype;Communicable Diseases;Complex;Dangerousness;Disease;Disease Outbreaks;Disease Outcome;ELF3 gene;Evolution;Exhibits;Gene Expression Profile;Genetic Variation;genome sequencing;Genus Mycobacterium;Granuloma;Immunocompetent;in vivo;in vivo Model;Infection;insight;Integration Host Factors;Length;Lung;Lung Diseases;M. tuberculosis genome;Macrophage;migration;Modeling;Modernization;Monitor;Motility;mouse model;Mus;mutant;Mycobacterium Infections;Mycobacterium marinum;Mycobacterium tuberculosis;Necrosis;North Carolina;Organ;Osteoblasts;Osteoclasts;overexpression;paralogous gene;Pathogenesis;Pathogenicity;Pathology;Patients;Persons;Phenotype;Proteins;recruit;Regulation;Resolution;Role;Site;skeletal;System;Testing;Tissues;Transcriptional Regulation;Transgenic Organisms;Translating;transmission process;Tropism;Tuberculosis;Variant;whole genome;Work;Zebrafish

PROJECT_TITLE: The Bacterial Genetic Basis of Bone Disease and Dissemination in Mycobacterial Infection: Roles of ESX-5 Secreted WXG Effectors

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Cancers are highly heterogeneous and the underlying mechanisms are driven in large part through mutations that are “silent”, but cause changes to protein isoform expression. This proposal will develop innovative, broadly applicable technologies to systematically link silent cancer mutations to splicing events and the functional impacts of their consequent protein isoforms. Such information will reveal highly specific cancer biomarkers, novel drug targets, and systems-biology-driven cancer treatments.

PI_NAMEs: SHEYNKMAN, GLORIA  (contact);YI, S. STEPHEN

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Acceleration;Affect;Affinity Chromatography;Alternative Splicing;Automobile Driving;Benchmarking;Biological;Biological Assay;Biological Markers;Biology;cancer biomarkers;Cancer cell line;cancer genome;cancer genomics;cancer heterogeneity;Cancer Patient;cancer therapy;Cell Line;Colorectal Cancer;Communities;computer framework;Coupled;Data Set;disease model;DNA Sequence Alteration;driver mutation;Drug Targeting;Event;exome sequencing;Gene Targeting;Genes;Genetic Heterogeneity;genome sequencing;Genomic approach;Genotype;Germ-Line Mutation;Immunotherapy;Individual;innovation;insight;Joints;Knowledge;Lead;Length;Link;Literature;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Melanoma;Methods;Mutation;neoantigens;Network-based;new therapeutic target;novel;Nucleic Acid Regulatory Sequences;Paper;Pathway interactions;patient population;Patients;Phenotype;Play;precision medicine;Prevalence;Production;Prognosis;Property;protein aminoacid sequence;protein expression;Protein Isoforms;protein protein interaction;Proteins;proteogenomics;Proteomics;Publications;Reporting;Resolution;Resources;RNA Splicing;Role;Sampling;Signal Transduction;Silent Mutation;Somatic Mutation;Surveys;synergism;System;Systems Biology;targeted cancer therapy;targeted treatment;Technology;Tissues;transcriptome sequencing;tumor;tumor progression;Validation

PROJECT_TITLE: An integrated functional proteomics platform for accelerated discovery of isoform-specific determinants of cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-Q (O1)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Patient Safety

ORG_DEPT: ANESTHESIOLOGY

PHR: Narrative (Public Relevance Statement) Cardiac inotrope medications used to augment heart contractility during recovery from cardiac surgery carry steep tradeoffs between risks (e.g., myocardial ischemia, malignant arrhythmia) and benefits (e.g., enhanced perfusion to vital organs), and are independently associated with 3-fold increased mortality and complication rates. Aside from patients with advanced cardiogenic shock wherein inotropes are necessary for survival past the operating room, limited evidence exists to support the ability of inotropes to improve survival or reduce complications among the majority of 300,000 patients undergoing cardiac surgery each year, and as a result, inotrope practice patterns vary widely across clinicians and hospitals, contributing to wide variation in mortality and major complication rates. We seek to (i) identify patient, clinician, and institution phenotypes associated with inotrope practice patterns; (ii) characterize and quantify institutional barriers to inotrope practice change; and (iii) estimate context-specific causal effects of inotropes on outcomes through a novel integration of cardiac surgical databases which address unmeasured confounders historically biasing previous observational studies.

PI_NAMEs: MATHIS, MICHAEL ROBERT (contact)

PROGRAM_OFFICER_NAME: ANAYA, GABRIEL

PROJECT_TERMS: Address;Adult;Adverse effects;Anesthesiology;Arrhythmia;Attitude;Automobile Driving;Benefits and Risks;Cardiac;Cardiac Surgery procedures;Cardiogenic Shock;Clinical;Clinical Trials;cohort;Complication;cost;Data;data registry;Data Set;Databases;Death Rate;design;Development;EHR research;Feedback;Future;Goals;Graph;Health system;Heart Contractilities;hemodynamics;Hospital Societies;Hospitals;improved;improved outcome;insight;Institution;Intensive Care Units;Interview;Life;Malignant - descriptor;member;Methods;Michigan;Minority;Modeling;Modernization;mortality;Multicenter Studies;Myocardial Ischemia;National Heart, Lung, and Blood Institute;novel;Nurses;Observational Study;Operating Rooms;Operative Surgical Procedures;Organ;Outcome;Pathway interactions;Patient risk;Patient-Focused Outcomes;Patients;Pattern;Perfusion;Perioperative;Pharmaceutical Preparations;Phenotype;Population;Postoperative Complications;preference;Process;Records;Recovery;Registries;Reporting;Research;Resources;Risk;Risk Factors;Risk Reduction;Role;Selection Bias;Societies;Specific qualifier value;Standardization;structural determinants;Structure;Surgeon;surgery outcome;surgical research;Surveys;Testing;Thoracic Surgeon;Traction;treatment as usual;Universities;Variant

PROJECT_TITLE: COmparing iNoTRope prACtice variaTION in Cardiac Surgery (CONTRACTION-CS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-F (90)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The goal of this study is to provide a comprehensive, robust, and generalizable test of multiple theory driven accounts of how negative and positive affect may be related to alcohol use behaviors. These data will test at what timescales, for what operationalization of affect and alcohol these associations are relevant, as well as when, how, and for whom these effects seem to be of greatest importance. This study will improve a mechanistic understanding of the role of affect in the development of alcohol use disorders.

PI_NAMEs: KING, KEVIN MICHAEL (contact);WRIGHT, AIDAN GREGORY CRAVER

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: Adult;Affect;Affective;alcohol abuse therapy;alcohol availability;Alcohol consumption;alcohol craving;alcohol use disorder;Alcohols;Behavior;Cognition;Cognitive;Consensus;coping;Coupled;craving;Data;Data Set;design;Development;Disease;disorder risk;drinking;Ecological momentary assessment;Emotions;Etiology;experience;experimental study;Future;Goals;improved;Individual;Intervention Studies;Intuition;Literature;Maintenance;Measures;Mediating;Modeling;negative affect;Outcome;Participant;Patient Self-Report;Persons;Psychological reinforcement;Regulation;reinforcer;Research;Research Design;Role;Sampling;Severities;Site;Social Environment;social norm;Specific qualifier value;Specificity;Symptoms;Testing;theories;Time;Validation;Variant;Work

PROJECT_TITLE: A multiverse analysis of the affect-alcohol use association

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-Q (02)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Contraception/Reproduction;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Physical Injury - Accidents and Adverse Effects;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Suicide;Violence Against Women;Violence Research;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Perinatal mood and anxiety disorders (PMADs) affect at least one in five birthing individuals and often underlie suicidal behavior and suicide itself. Environmental influences, such as individual level health or economic stressors, and macro stressors, such as restricted access to reproductive health care, may precipitate suicidal behavior. This study examines the impact of restricting reproductive health services on population health, including PMAD rates, suicidality and maternal health outcomes, and mental health service use.

PI_NAMEs: DALTON, VANESSA K. (contact);ZIVIN, KARA

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: abortion;access restrictions;Address;adverse pregnancy outcome;Affect;Age;Anxiety Disorders;Area;Birth;Caring;Clinical;County;court;Data;design;Diagnosis;Disparity;Divorce;Economics;Emergency department visit;Enrollment;ethnic minority;Ethnic Origin;Ethnic Population;Feeling suicidal;Funding;Future;Geography;Goals;Health;health care service;health organization;health service use;Health Services Accessibility;Healthcare;Heterogeneity;improved;Income;indexing;Individual;inpatient psychiatric treatment;Insurance;insurance claims;Interruption;Intervention;intervention delivery;large datasets;Laws;Legal Abortion;Link;Low income;Marriage;Maternal Health;maternal morbidity;Maternal Mortality;Medicaid;Medical;Mental disorders;Mental Health;Mental Health Services;Monitor;Mood Disorders;Morbidity - disease rate;National Institute of Mental Health;Natural experiment;neighborhood disadvantage;Outcome;Outpatients;Overdose;Patient Self-Report;Perinatal;perinatal mental health;perinatal period;peripartum depression;Policies;Population;population health;Postpartum Period;Pregnancy;Pregnancy Outcome;Quasi-experiment;Race;racial minority;racial population;remote group;reproductive;Reproductive Health;Reproductive Health Services;Research;Research Support;Risk;Risk Assessment;Risk Factors;same-sex marriage;Self-Injurious Behavior;Series;Services;social deprivation;stressor;Subgroup;suicidal;suicidal behavior;suicidal individual;suicidal morbidity;Suicide;suicide rate;Symptoms;System;therapy development;Time;Travel;unintended pregnancy;United States;Unwanted pregnancy;Vision;Vulnerable Populations;Woman;Women's Health;Work

PROJECT_TITLE: Impact of reproductive health restrictions on women's mental health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences;Prevention

ORG_CITY: MILWAUKEE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: NARRATIVE This project is of benefit to public health because, as visual disorders are on the rise, there is a greater need than ever to both understand the root causes of retinal degenerations, and to use this knowledge to develop preventive treatments and restorative therapeutics. We will use the cone-rich zebrafish animal system to dissect the role(s) played by STRA6 to modulate retinoid and JAK-STAT signaling in the RPE, examining the contribution of STRA6 to RPE cell survival and function. These studies will shed light on novel functions and mechanisms of STRA6, whose previous annotation has focused almost exclusively on its role as a retinoid transporter to maintain the visual cycle, and, in doing so, we will uncover new targets and routes of intervention to prevent loss of RPE cells, which underpin the health of the photoreceptors.

PI_NAMEs: COLLERY, ROSS F (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Acceleration;Address;Adult;All-Trans-Retinol;Amino Acids;Animal Model;Animals;Anophthalmos;Biological;Biological Models;Biology;Blindness;Blood;Cell Physiology;Cell Survival;Choroid;Clinical;combat;Complex;Cone;CRISPR/Cas technology;Cytokine Signaling;Data;density;Dietary Supplementation;Disease;effective therapy;Ensure;Epithelium;Evaluation;Event;experimental study;Eye;Eye diseases;Functional disorder;Future;Gene Deletion;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Health;Homeostasis;Human;improved;Individual;Intervention;Investigation;Knowledge;Ligands;Maintenance;Mediating;Mediator;Methods;Microphthalmos;Mitochondria;Modeling;Molecular;mutant;Mutation;Neural Retina;novel;Outcome;Oxidation-Reduction;Oxidative Stress;Pathway interactions;Patients;Phenotype;photoreceptor degeneration;Photoreceptors;Pigment Epithelium of Eye;Play;prevent;Preventive treatment;Process;Public Health;pulmonary hypoplasia;RBP4 gene;Receptor Signaling;Regulation;Research;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;Retinal Dystrophy;Retinoids;Rod Outer Segments;Role;Route;Signal Pathway;Signal Transduction;Stargardt's disease;Starvation;Strategic Planning;Structure of retinal pigment epithelium;Surface;Symptoms;Syndrome;System;targeted treatment;Testing;Therapeutic;therapeutic target;therapy development;Tissues;tool;Transcriptional Regulation;transcriptome;transcriptomics;Transgenic Organisms;treatment strategy;Tretinoin;Vertebrate Photoreceptors;Vision;Vision Disorders;visual cycle;Wood material;Zebrafish

PROJECT_TITLE: Retinoid Signaling and Homeostasis in the Eye

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF IOWA

PHR: PROJECT NARRATIVE  The proposed project is relevant to public health because the knowledge gained from the project will directly facilitate accessible, affordable, and quality hearing healthcare and improve amplification intervention outcomes. The proposed study is relevant to the part of NIH/NIDCD’s mission that pertains to facilitating better outcomes for human communication and improving the quality of life of Americans with hearing loss.

PI_NAMEs: WU, YU-HSIANG  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Address;Adopted;Adoption;Adult;Affect;American;amplification device;Behavior;Caring;Characteristics;cognitive function;Communication;Data;Decision Aid;Decision Making;Devices;dexterity;Diagnosis;Economics;emotional functioning;Ensure;experience;Fingers;Funding;Future;health literacy;Healthcare;Hearing;Hearing Aids;hearing impairment;Hearing Tests;High Prevalence;Human;Hybrids;improved;Individual;Individual Differences;Internet;Intervention;Interview;Iowa;Knowledge;Licensing;Longitudinal Studies;Maintenance;Manufacturer;Methods;Mission;Modeling;National Institute on Deafness and Other Communication Disorders;Outcome;Participant;Pathway interactions;Patient-Focused Outcomes;Patients;Performance;Personal Attribute;Personal Satisfaction;Persons;Pharmacy facility;Predictive Factor;preference;Presbycusis;prevent;Process;programs;Provider;psychosocial;Public Health;Quality of life;Randomized, Controlled Trials;recruit;Reporting;Research;satisfaction;self diagnosis;Self Management;service delivery;Service delivery model;Site;Social Functioning;success;theories;Time;tool;United States National Institutes of Health;uptake;Visit;Weight;willingness

PROJECT_TITLE: Barriers and facilitators to over-the-counter hearing aids success: A patient journey approach

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Genetics;Heart Disease;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative The proposed research is relevant to public health because neurodegenerative and cardiac diseases are major causes of morbidity and mortality in this country. The proposed research exploits new transgenic mouse models that use the chemogenetic production of reactive oxygen species in blood vessels and neurons to identify the key oxidative stress pathways that cause human diseases, including Friedreich’s ataxia, cardiac hypertrophy, Alzheimer’s Disease and Alzheimer’s-related dementias. The discoveries made in the proposed research program may lead to the identification of new therapeutic targets.

PI_NAMEs: MICHEL, THOMAS  (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Alanine;Alzheimer's Disease;Alzheimer's disease related dementia;Amino Acids;Animals;Ataxia;Autopsy;behavior test;behavioral study;Biochemical;Biological Models;Blood;Blood Vessels;blood-brain barrier disruption;Brain;Cardiac;Cardiac Myocytes;Cells;Chronic;Chronic Disease;Cognition;Country;D-Amino Acid Dehydrogenase;Dementia;Disease;Dorsal;drinking water;Echocardiography;Endothelial Cells;Endothelium;Enterobacteria phage P1 Cre recombinase;Enzymes;feeding;Friedreich Ataxia;Ganglia;Genetic;genetic approach;Goals;Heart Diseases;Heart failure;Heart Hypertrophy;Human;human disease;Hydrogen Peroxide;Image;Impaired cognition;in vivo;inflammatory marker;Inherited Spinocerebellar Degenerations;Investigation;Mammalian Cell;Metabolic;metabolomics;Mitochondria;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Myopathy;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neurovascular;new therapeutic target;Nodose Ganglion;Oxidases;Oxidative Stress;Oxidative Stress Pathway;Pathogenesis;Pathway interactions;Pattern;pharmacologic;Phenotype;Physiological;Play;Prevention;Process;Production;programs;promoter;Proteomics;Public Health;Reactive Oxygen Species;Research;response;Role;Sensory;Sensory Ataxias;sensory neuropathy;Spinal Cord;Spinal Ganglia;Testing;Tissues;transcriptomic profiling;transcriptomics;transgene expression;Transgenes;Transgenic Mice;Transgenic Organisms;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;Vascular Diseases;Yeasts

PROJECT_TITLE: Chemogenetic neurovascular oxidative stress: neurodegeneration and cardiac remodeling

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Pancreatic Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE Public Health Relevance: Intraductal papillary mucinous neoplasms (IPMNs) are cystic precursor lesions to pancreatic ductal adenocarcinoma (PDAC) incidentally-detected by imaging in more than 500,00 Americans each year. There is an unmet need to discover noninvasive approaches to differentiate ‘low- risk/benign’ IPMNs that can be monitored from ‘high-risk/malignant’ IPMNs that warrant surgery and its associated risks of morbidity and mortality. In our parent award, we are evaluating the hypothesis that radiomic features extracted from preoperative computed tomography (CT) scans will more accurately predict IPMN pathology than conventional radiologic features, both individually and in combination with a plasma- based ‘miRNA genomic classifier’ (MGC). In this extension, we plan to 1) evaluate the value of artificial intelligence (AI)-driven CT deep learning radiomic features in predicting malignant versus benign IPMN pathology in retrospective and prospective cohorts, 2) evaluate telomere length and telomerase activity in the blood as candidate molecular markers of high-grade IPMNs or early-stage PDAC, and 3) use behavioral AI to predict malignant transformation among patients with a high risk to develop PDAC.

PI_NAMEs: JEONG, DANIEL ;PERMUTH, JENNIFER B (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: 3-Dimensional;Address;American;anti-cancer research;Anxiety;Artificial Intelligence;Behavioral;Benign;Biological Markers;Biological Process;Biology;Blood;candidate marker;Carcinoma;Clinical;clinical decision-making;Clinical/Radiologic;clinically actionable;Consensus;cost;Cyst;Cystic Neoplasm;Data;deep learning;Development;Diagnostic;diagnostic value;Disease;Dysplasia;Early Diagnosis;Enzyme-Linked Immunosorbent Assay;Epidemic;Excision;Eye;Family;Florida;Fostering;genomic signature;Goals;Guidelines;Health;High grade dysplasia;high reward;high risk;Human;Image;imaging approach;imaging detection;Immunohistochemistry;improved;In Situ Hybridization;Incidental Findings;Individual;Institution;Invaded;Knowledge;Lead;Length;Lesion;Link;liquid biopsy;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;Medical Imaging;MicroRNAs;Mission;molecular marker;Monitor;Morbidity - disease rate;mortality;Mucinous Neoplasm;Mucins;Nomograms;Operative Surgical Procedures;Outcome;overtreatment;Pancreas;Pancreatic Cyst;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;Papillary;parent grant;parent project;Pathologic;Pathology;Patients;Performance;personalized care;Persons;Plasma;Portraits;predictive modeling;Predictive Value;premalignant;prevent;Prevention;Procedures;prospective;Prospective cohort;prototype;public health relevance;quantitative imaging;Radiogenomics;Radiology Specialty;radiomics;Research;Retrospective cohort;Risk;Scanning;Scientific Advances and Accomplishments;Series;Serum;Severities;Societies;Specificity;Survival Rate;Techniques;Telomerase;telomere;Tissue Microarray;Tissues;tool;Translational Research;translational study;Tumor Pathology;Tumor Tissue;X-Ray Computed Tomography

PROJECT_TITLE: Using Radiogenomics to Noninvasively Predict the Malignant Potential of Intraductal Papillary Mucinous Neoplasms of the Pancreas and Uncover Hidden Biology


NIH_SPENDING_CATS: Biotechnology;Genetics;Immunization;Infectious Diseases;Sexually Transmitted Infections;Vaccine Related

PHR: Chlamydia is the most common cause of bacterial sexually transmitted infections and can lead to pelvic inflammatory disease, life-threatening ectopic pregnancies, and infertility in women. Disease is linked to the ability of Chlamydia to undermine human host defense and establish persistent infections. This research will define how Chlamydia induces inflammation but avoids clearance by human immune programs, and it will thereby pave the way towards the development of novel treatment options and improved vaccine strategies.

PI_NAMEs: COERS, JOERN  (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: adaptive immunity;antagonist;Autophagocytosis;bacterial genetics;blocking factor;Cell Culture System;Cells;Chemicals;Chimera organism;Chlamydia;Chlamydia Infections;Chlamydia muridarum;Chlamydia trachomatis;chronic infection;cytokine;Data;design;Development;Disease;Dynamin;Eating;Ectopic Pregnancy;Epidemic;Epithelial Cells;Failure;Female infertility;Follow-Up Studies;functional genomics;Genes;Genetic Screening;Goals;Guanosine Triphosphate Phosphohydrolases;Host Defense;Host resistance;Human;Immune;immune clearance;Immune system;Immunity;immunopathology;improved;in vivo;Infection;Infertility;Inflammation;Inflammatory Response;innate immune pathways;insight;interdisciplinary approach;Interferon Type II;Interferons;Libraries;Life;Link;Lymphocyte;Maps;Mediating;Modeling;Monitor;mouse model;Mouse Strains;Mus;Mutagens;mutant;Natural Immunity;novel;novel therapeutics;Organoids;Orthologous Gene;pathogen;Pathogenesis;Pathology;Pathway interactions;Pelvic Inflammatory Disease;Phylogenetic Analysis;Physiological;Predisposition;programs;prophylactic;Prophylactic treatment;Proteins;Regulation;Research;Resistance;resistance factors;Rodent;Role;Sexually Transmitted Diseases;Signal Transduction;System;Testing;Therapeutic;Therapeutic Intervention;therapy design;Ubiquitin;ubiquitin-protein ligase;Vaccine Design;vaccine strategy;Vaccines;Vacuole;Virulence Factors;Woman;Work

PROJECT_TITLE: Interferon-inducible cell-intrinsic host defense against Chlamydia trachomatis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-P (02)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: PROVIDENCE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative In this proposal, by means of behavioral testing, we aim to clarify how vision is improved by visual training. The proposed investigations would lead to a significantly better understanding of visual and brain plasticity, which may lead to interventions to amblyopia, and other pathological or age-related visual declines.

PI_NAMEs: WATANABE, TAKEO  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Address;age related;Amblyopia;Area;Arousal;behavior test;Brain;Brain region;Categories;Characteristics;clinical application;clinical training;Cognitive;Development;experimental study;Exposure to;extrastriate visual cortex;Goals;Grant;improved;information processing;insight;Intervention;Investigation;Learning;Life;Location;Methods;Neurons;Pathologic;Perceptual learning;Play;Process;programs;Property;Psychological reinforcement;Psychophysics;receptive field;Rehabilitation therapy;Research;Research Personnel;Retina;Rewards;Role;selective attention;Specificity;Stimulus;Testing;tool;Training;Vision;Visual;visual information;visual plasticity

PROJECT_TITLE: Comprehensive frameworks of perceptual learning

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative We propose to develop a new technology to ultrasensitively quantify proteins, DNA, and single extracellular vesicles in an integrated device, directly in patient blood, to address critical issues in multimodal diagnostics. In collaboration with the Abramson Cancer Center and building on prior work together on multi-modal diagnostics, we focus our attention on Pancreatic ductal adenocarcinoma -the third leading cause of cancer-related death in the United States with an overall 5-year survival of only 9%. In the proposed work, we will develop our technology to a level of maturity that it can measure multi-modal panels of relevant PDAC biomarkers at ultra-high sensitivity, high linearity, and dynamic range in plasma to diagnose PDAC at earlier stages and to more accurately guide the treatment of patients with PDAC than is currently possible.

PI_NAMEs: ISSADORE, DAVID AARON (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Address;Agreement;Attention;Automation;Biological Assay;Biological Markers;biomarker panel;Blood;Blood Plasma Volume;Blood Volume;Cancer Center;Cancer Detection;Cancer Etiology;Cancer Patient;CCR;Cellular Phone;Cessation of life;Clinical;clinical translation;cohort;Collaborations;design;Detection;detection limit;detector;Devices;Diagnosis;Diagnostic;diagnostic value;digital;disease diagnosis;disorder control;DNA;DNA Markers;Emerging Technologies;Endoscopic Biopsy;Enzyme-Linked Immunosorbent Assay;experimental study;extracellular vesicles;Fluorescence;Heterogeneity;Hybrids;Immune;improved;Individual;Industry;innovation;instrumentation;Laboratories;laboratory equipment;Letters;Light;liquid biopsy;Magnetic Resonance Imaging;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Measures;Methods;microelectronics;Microfluidic Microchips;Molecular;molecular diagnostics;multimodality;nano;new technology;operation;Pancreatic Ductal Adenocarcinoma;Patients;Performance;Phenotype;Plasma;precision oncology;prospective;Proteins;Reaction;recruit;Research;research clinical testing;Resolution;RNA;Sampling;screening;Sensitivity and Specificity;single molecule;Specificity;Staging;success;targeted cancer therapy;Technology;technology development;technology platform;technology validation;Telecommunications;Testing;Training;tumor DNA;United States;Work

PROJECT_TITLE: High Throughput Digital Droplet Assays for Ultrasensitive Multimodal (DNA, RNA, and Protein) Diagnostics


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative Integrating statistical analyses of nationally representative data with quantitative and qualitative analyses of physiological, cognitive, social, and psychological data from a diverse lab-based sample to document and unpack how racial/ethnic disparities in exposure to family member deaths early in life may destabilize socioeconomic and family-building trajectories into young adulthood, this project will focus attention on a key domain through which this early trauma has lifelong consequences for health, elucidate biopsychosocial mechanisms underlying this life course process that are amenable to intervention, and identify potentially actionable supports for resilience. This theoretically grounded, policy-focused, and pilot-validated research can significantly address an overlooked channel in the intergenerational transmission of racial/ethnic inequality affecting vulnerable Americans, capturing the spirit of Healthy People 2030 and advancing many goals of NIH.

PI_NAMEs: CROSNOE, ROBERT LYLE (contact);UMBERSON, DEBRA J.

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Achievement;Address;Adolescence;Adolescent;Adult;adverse childhood events;Affect;Affective;Age;American;Arousal;Attention;Bereavement;Biological;Biological Markers;biopsychosocial;Biosocial;Birth;Black American;Black race;Cessation of life;Childhood;Cicatrix;Cognition;Cognitive;Coping Behavior;Data;Data Collection;design;Developmental Process;diaries;Disparity;Early-life trauma;Education;emotion dysregulation;emotion regulation;Employment;Equation;ethnic difference;ethnic disparity;Ethnic Origin;Ethnic Population;experience;Exposure to;Family;Family member;Fathers;Foundations;Funding;Future;Goals;Health;health data;health disparity;Health Promotion;Human Development;Individual;innovation;insight;Institute of Medicine (U.S.);Institution;Interdisciplinary Study;interest;intergenerational;Intervention;Interview;Laboratories;Learning;Life;Life Cycle Stages;Life Experience;Link;Literature;longitudinal design;Longitudinal Studies;Measures;Mediation;Mediator;Mental Health;Methods;Minority;Modeling;mortality;mortality disparity;Movement;National Longitudinal Survey of Adolescent to Adult Health;pandemic disease;Pathway interactions;Pattern;personalized approach;Persons;Physical assessment;Physiological;Policies;Population;population health;premature;Process;Proliferating;protective factors;Protocols documentation;Psyche structure;psychologic;Public Health;Race;racial difference;racial disparity;racial population;Recommendation;Recording of previous events;Records;Research;Research Methodology;resilience;response;Risk;Role;Running;Sampling;Scientist;Secure;Self Medication;Sequence Analysis;Services;Siblings;social;social factors;Social Justice;social relationships;Social support;Societies;socioeconomics;sociologist;Sociology;Source;Statistical Data Interpretation;Stress;structured data;Surveys;Symptoms;Techniques;Teenagers;Testing;theories;tool;transition to adulthood;Translational Research;transmission process;United States National Institutes of Health;visual map;wearable data;wearable device;young adult;Youth

PROJECT_TITLE: Early Family Member Deaths and Disrupted Transitions into Adulthood

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-R (90)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Electronic Nicotine Delivery Systems;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE  In response to PAR-21-138: Method to Extend Research in Time (MERIT) Award Extension Request, this 2- year MERIT extension proposes to enroll a sample of adults (ages 18-40; N=70) who are using e-cigarettes (vaped nicotine) daily or near daily and are co-using cannabis. The parent R37 study (R37 CA237245, PI McClure) is focused on the role of cannabis co-use on tobacco (cigarette) cessation, and this MERIT extension will leverage the methods, measures, and procedures of the parent R37 but with an expanded focus on e- cigarette cessation and the role of cannabis co-use as a barrier (or facilitator) to cessation. This MERIT extension represents an important, timely and logical next step to the parent R37 award, which will advance the field of co- use and contribute to understanding the relationship and treatment implications of tobacco/nicotine and cannabis co-use.

PI_NAMEs: MCCLURE, ERIN A (contact)

PROGRAM_OFFICER_NAME: REYES-GUZMAN, CAROLYN

PROJECT_TERMS: Abstinence;Adult;Age;Award;Biochemical;Cannabis;Characteristics;Cigarette;cigarette smoking;combustible tobacco;Data;Data Collection;design;Dose;e-cigarette cessation;Electronic cigarette;electronic cigarette use;Electronic Nicotine Delivery Systems;Enrollment;Evaluation;Exclusion;falls;Frequencies;Funding;Goals;interest;Literature;marijuana use;Measures;Methods;Nicotine;nicotine cessation;Outcome;parent grant;parent project;Parents;Participant;participant enrollment;Pattern;Play;Population;Procedures;prospective;Recommendation;recruit;Research;response;Role;Sampling;Severities;Smoking;Time;Tobacco;tobacco products;Tobacco use;Tobacco Use Cessation;treatment trial;trend;United States;vaping nicotine;varenicline;Youth

PROJECT_TITLE: Determining the impact of cannabis use and severity on tobacco cessation outcomes: A prospective tobacco treatment trial


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Regenerative Medicine

PHR: PROJECT NARRATIVE Inappropriate type I interferon (IFN) signaling is associated with excessive immunopathology during and after influenza A virus infection. We performed a genome wide over-expression screen for previously undescribed controllers of IFN signaling and identified the interferon stimulated gene ETV7 as a transcriptional suppressor of this pathway. The major goal of this application is to define the mechanisms underlying ETV7 function to enable novel intervention strategies which limit immunopathology and enhance lung regeneration after viral infection.

PI_NAMEs: HEATON, NICHOLAS S (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;Affect;Affinity;AGTR2 gene;airway epithelium;Animal Model;Anti-viral Response;Binding;Biochemical;Biology;Cell Culture Techniques;Cell Survival;cell type;Cells;Complex;Computer Models;CRISPR-mediated transcriptional activation;cytokine;Data;Disease;Distal;DNA;DNA Binding;Epithelial Cells;Epithelium;epithelium regeneration;Equilibrium;ETV6 gene;experimental study;Family;Gene Expression;Gene Modified;Genes;Genetic;genetic regulatory protein;Genetic Transcription;genome-wide;Goals;Human;immunopathology;in vivo;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;Influenza;Influenza A virus;Influenza B Virus;influenza infection;influenzavirus;Innate Immune Response;insight;Interferon Type I;Interferons;Intervention;Investigation;Kinetics;Knowledge;Lung;lung regeneration;Mediating;Medical;Modeling;Morbidity - disease rate;mortality;Mus;Natural Immunity;Natural regeneration;novel;overexpression;Pathogenesis;pathogenic virus;Pathway interactions;Pattern recognition receptor;Physiological;Play;Population;Positioning Attribute;preservation;prevent;Production;progenitor;Proliferating;promoter;Promoter Regions;prototype;Pulmonary Inflammation;Recovery;regeneration model;regeneration potential;regenerative;Regulation;Regulatory Element;Regulatory Pathway;Research;Resolution;response;Role;screening;Severities;Signal Pathway;Signal Repression;Signal Transduction;Site;stem cells;Testing;tissue regeneration;transcription factor;Transgenes;Variant;Viral;Viral Pathogenesis;Viral Physiology;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: ETS-family Transcription Factor Mediated Control of Pulmonary Inflammation Induced by Influenza Viruses

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prostate Cancer;Rural Health;Social Determinants of Health;Urologic Diseases

ORG_DEPT: UROLOGY

PHR: PROJECT NARRATIVE This study will shed light on relationships between physician practice consolidation, and delivery of care for an exceedingly common cancer. These issues have been virtually unstudied to date and have implications for specialty care in other disciplines that are experiencing similar trends in consolidation. Findings will have real-world implications for patients, who are naturally interested in getting the best possible prostate cancer care.

PI_NAMEs: HOLLENBECK, BRENT K.;RYAN, ANDREW M;SHAHINIAN, VAHAKN B (contact)

PROGRAM_OFFICER_NAME: DAVIDOFF, AMY

PROJECT_TERMS: Adherence;advanced disease;advanced prostate cancer;adverse event risk;cancer care;Cancer Etiology;care coordination;care delivery;Caring;Cessation of life;Data;design;Diagnostic;Diagnostic tests;Discipline;Disease;end of life;Ensure;Equity;experience;financial incentive;Fostering;Guidelines;health care delivery;Health Insurance Reimbursement;Health Policy;Health Resources;Health Services Accessibility;Healthcare;Heterogeneity;high risk men;hospital utilization;Hospitalization;Hospitals;Impairment;Improve Access;improved;Incentives;Indolent;Infrastructure;Inpatients;interest;Intervention;Malignant neoplasm of prostate;Malignant Neoplasms;Marketing;Measures;Mediation;medical specialties;Medicare;Medicare claim;men;Monitor;mortality risk;Motivation;Nature;Newly Diagnosed;Oral;Ownership;Patients;Performance;Physicians;Population;Price;Privatization;Provider;provider behavior;Quality of Care;Radiation;Recommendation;residence;Rural;rural area;Services;Statutes and Laws;targeted agent;targeted treatment;Therapeutic;Toxic effect;Travel;trend;Trust;tumor;Uncertainty;Urologist;Urology;Variant;virtual;Work

PROJECT_TITLE: Urology practice consolidation and care for men with prostate cancer

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: PROJECT NARRATIVE Kennedy’s disease is a progressive neurodegenerative disease caused by an abnormal androgen receptor (AR) protein. There is currently no effective treatment available to slow, stop, or reverse the disease. Based on the promising preclinical results obtained with our 1st generation selective AR degraders (SARDs), this R01 application proposes to perform structure-activity relationship (SAR) and mechanistic studies to optimize a lead SARD that will be developed for Kennedy’s disease.

PI_NAMEs: NARAYANAN, RAMESH  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: advanced prostate cancer;Androgen Receptor;androgen sensitive;androgenic;Animal Genetics;Animal Model;Animals;antagonist;Area;Binding;Biological Assay;Biological Availability;Biology;Castration;Cells;clinical development;Data;design;Disease;Dose;Drug Kinetics;drug metabolism;effective therapy;efficacy evaluation;Evaluation;Excision;Exhibits;experience;experimental study;Generations;Genetic;Goals;histological studies;Hormone Receptor;Hormones;improved outcome;In Vitro;in vivo;in vivo Model;Kennedy Syndrome;Knock-out;Knowledge;Lead;Liver Microsomes;Medical;Modeling;Modification;motor neuron degeneration;Motor Neurons;mouse model;multicatalytic endopeptidase complex;Mus;Musculoskeletal;mutant;N-terminal;neurobehavior;Neurodegenerative Disorders;neuromuscular;Neurons;neurotoxic;neurotoxicity;novel;novel strategies;novel therapeutics;Oral;Pathologic;Pathology;Pathway interactions;patient - derived stem cells;Patients;PC12 Cells;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;Phenotype;Phosphorylation;polyglutamine;Post-Translational Protein Processing;pre-clinical;Pre-Clinical Model;preclinical development;Prevention;programs;Property;prostate cancer model;Proteins;prototype;Rattus;receptor;Receptor Activation;receptor binding;Research;Resistance;screening;skeletal muscle wasting;small molecule;Spinal;spinal and bulbar muscular atrophy;Spinobulbar Muscular Atrophy;stem cell biology;stem cell differentiation;Structure-Activity Relationship;Study models;Testing;Testosterone;Therapeutic;Therapeutic Agents;Tissues;Toxic effect;Transactivation;Transgenic Mice;Ubiquitin;Ubiquitination

PROJECT_TITLE: Discovery of Novel Selective Androgen Receptor Degraders (SARDs) for the Treatment of Spinobulbar Muscular Atrophy (SBMA) or Kennedy’s Disease

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project Narrative  Maintenance of ER protein homeostasis (proteostasis) is a fine balancing act between protein synthesis, folding and degradation. Mis-regulation of any one of these processes leads to perturbed ER proteostasis and activation of the unfolded protein response (UPR). ER stress and UPR activation is a major contributor to many human diseases. Here we investigate mechanisms that prevent protein mis-folding in the ER with a focus on how protein synthesis is regulated at the ER.

PI_NAMEs: RAMAN, MALAVIKA  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: ATF6 gene;Binding;Binding Proteins;Biogenesis;biological adaptation to stress;Biotinylation;Cell Death;Cells;Chemistry;cofactor;Competence;Coupled;Cues;Cystic Fibrosis;Data;Defect;Disease;endoplasmic reticulum stress;Equilibrium;Estrogen Receptor Status;Funding;Genetic Transcription;human disease;innovation;insight;interest;Label;Maintenance;Mass Spectrum Analysis;Mediating;Messenger RNA;misfolded protein;Modification;Molecular;molecular imaging;Nerve Degeneration;Null Lymphocytes;p97 ATPase;Pathway interactions;polypeptide;Polyribosomes;Positioning Attribute;prevent;Process;programs;protein aggregation;Protein Biosynthesis;protein degradation;protein misfolding;Proteins;Proteome;Proteomics;proteostasis;proteostasis loss;Puromycin;Quality Control;Repression;Research;response;Ribosomal Proteins;ribosome profiling;Ribosomes;Role;Signal Transduction;single molecule;stressor;System;Testing;Therapeutic;Transcript;transcription factor;translational impact;Translational Regulation;Translational Repression;Translations;Ubiquitin;Up-Regulation;Work;XBP1 gene

PROJECT_TITLE: Mechanisms regulating ER Proteostasis

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Disability Research;Osteoporosis;Women's Health Research

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative – Osseosurface Electronics – Chronic Wireless Battery Interfaces for Osteoporosis Treatment and Discovery Osteoporotic fractures account for more hospital bed days than myocardial infarction, breast cancer or prostate cancer. Currently there is no method to measure bone health continuously in vivo resulting in suboptimal care. Here we propose the development of ultrathin wireless, battery free fully implantable monitors of bone health to enable management and discovery for osteoporosis.

PI_NAMEs: GUTRUF, PHILIPP  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: 2 year old;Acute;Age;Age Years;Animal Model;Bed Occupancy;bone;Bone Density;bone health;bone quality;Budgets;calcium phosphate;calcium phosphate coating;Caring;Ceramics;Chronic;Clinical;cortical bone;cost;cost estimate;Cost Savings;Data;deep neural network;Development;Devices;Diagnosis;diagnosis standard;Diagnostic;disability;disability-adjusted life years;Disease;Dual-Energy X-Ray Absorptiometry;Effectiveness;efficacy evaluation;electric impedance;Electronics;Engineering;Exercise;experimental study;Forteo;Fracture;fracture risk;fragility fracture;Free Will;Future;Gait;Genetic;Growth;Healthcare;Hip Fractures;hospital bed;Image Analysis;Implant;improved;in vivo;Incidence;innovation;insight;Investigation;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Measurement;Measures;Methods;Modality;Modeling;Monitor;mortality;multimodality;Myocardial Infarction;operation;Osteopenia;Osteoporosis;osteoporosis with pathological fracture;Ovariectomy;parathyroid hormone (1-34);particle;Patients;Performance;Persons;Pharmaceutical Preparations;Population;Prevalence;PTH gene;Quality of life;rapid test;Resolution;Risk;Risk Factors;Rodent;Rodent Model;Savings;Secondary to;sensor;Skin;Surface;Technology;Temperature Sense;temporal measurement;Testing;Therapeutic;Thermal Conductivity;Time;tool;translational study;treadmill;treatment response;wireless;wireless electronic;Work

PROJECT_TITLE: Osseosurface Electronics: Chronic Wireless Battery Interfaces for Osteoporosis Treatment and Discovery

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Cachexia;Cancer;Prevention

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Recently we discovered that cancer causes cachexia by disrupting the body’s natural resolution mechanism of inflammation caused by cellular debris, triggering both a lipid mediator and cytokine storm in mice. To stimulate the natural debris-clearing process (pro-resolution), we utilized resolvins, which are small molecule non-toxic lipid molecules produced by the human body. We’ve assembled a team of world-class investigators to study underlying mechanisms of resolution of inflammation as an entirely novel, paradigm-shifting approach to pre- vent and/or reverse cachexia in pre-clinical systems and patients.

PI_NAMEs: FREEDMAN, STEVEN DAVID;PANIGRAHY, DIPAK  (contact);SERHAN, CHARLES NICHOLAS

PROGRAM_OFFICER_NAME: GOOD, MARGE

PROJECT_TERMS: Acceleration;Adipocytes;adipokines;Advanced Malignant Neoplasm;Animal Model;Animals;Anti-Inflammatory Agents;Apoptosis;Apoptotic;Autacoids;Biochemical Process;Body Weight decreased;Cachexia;Cancer Cachexia;Cancer Control;Cancer Etiology;Cancer Patient;cancer therapy;Catabolism;CD59 Antigen;Cell Death;Cells;Cessation of life;chemotherapy;Clinical;clinical translation;Clinical Trials;Complement;computer framework;control trial;cytokine;cytokine release syndrome;cytotoxic;Deterioration;Disease;disease phenotype;Dose;Eicosanoids;Excision;Exhibits;Fatty acid glycerol esters;Genetic;Heart;Homeostasis;Human;Human body;Immunosuppression;Induction of Apoptosis;Inflammation;Inflammation Mediators;Inflammatory;innovation;Intervention;lipid mediator;Lipids;Liver;Lung;Lymphocyte;Macrophage;Malignant Neoplasms;Mediating;Mediator;Medical;Medicine;Metabolic;Metabolic dysfunction;Micrometastasis;mimetics;Modeling;Molecular;Multiple Organ Failure;Mus;Muscle;muscle regeneration;Muscular Atrophy;nano;Necrosis;Neoplasm Metastasis;novel;novel strategies;Nutritional;Parabiosis;Patients;Phagocytosis;pharmacologic;Phase;Plasma;pre-clinical;precision nutrition;prevent;Prevention;Primary Neoplasm;Process;programs;protein degradation;receptor;Recurrent tumor;Regulation;repaired;Research Personnel;Resolution;restoration;Role;Site;Skeletal Muscle;skeletal muscle wasting;small molecule;Spleen;Syndrome;System;systemic inflammatory response;Testing;tissue regeneration;Tissues;Toxic effect;Translations;tumor;tumor growth;tumor progression;Wasting Syndrome

PROJECT_TITLE: Control of cancer cachexia via stimulation of resolution of inflammation

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


PHR: Military personnel are involved in activities such as nuclear weapon testing (atomic veterans), nuclear power plant operation and nuclear accident cleanup that put them at high risk for radiation exposure. Radiation exposure can cause acute radiation syndromes associated with severe morbidity and mortality, and chronic long-term effects that culminate in development of cancer. The role of cytoplasmic sensors in radiation-induced acute radiation syndromes remain understudied. Here we examine the importance of RIPK2 signaling axis (an adaptor protein for cytoplasmic sensors NLRC1 and NLRC2) and RIPK2-associated microbiota in regulating radiation-induced acute sickness and death. Successful completion of this project will demonstrate a pathogenic role for RIPK2 in driving radiation-induced sickness.

PI_NAMEs: GURUNG, PRAJWAL  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acute;Adaptor Signaling Protein;Adverse effects;Affect;Antibiotics;atomic bomb;Automobile Driving;Bacteria;Biochemical;cancer risk;CASP1 gene;Cell Death;Cell Death Induction;Cessation of life;Chronic;Cytoplasm;Cytoplasmic Protein;Data;Death Rate;Development;DNA;early onset;Endothelium;experimental study;Exposure to;fecal microbiome;gastrointestinal epithelium;genetic approach;Goals;gut microbiome;gut microbiota;Health;high risk;Human;Human Activities;Immune system;Inflammasome;Inflammatory;interest;Knockout Mice;Long-Term Effects;Malignant Neoplasms;Mediating;Medical;Medicine;microbial;microbiome signature;microbiota;Military Personnel;military veteran;Molecular;Morbidity - disease rate;mortality;Mus;new therapeutic target;novel strategies;novel therapeutics;Nuclear;Nuclear Accidents;Nuclear Power Plants;Nuclear Weapons Testings;Occupations;Onset of illness;operation;Outcome;Pathogenicity;Pathway interactions;Personal Satisfaction;Persons;Phosphotransferases;Play;prevent;Preventive;Process;Protein Kinase Interaction;Radiation;Radiation Dose Unit;radiation effect;Radiation exposure;radiation hazard;Radiation Induced DNA Damage;Radiation therapy;Radiation Toxicity;receptor;Receptor-Interacting Protein;Resistance;RIPK2 gene;Risk;Roentgen Rays;Role;Science;sensor;Signal Transduction;Space Explorations;targeted treatment;Technology;Testing;Therapeutic;Tissues;Toxic effect;United States Department of Veterans Affairs;Veterans;Western Blotting;X-Ray Computed Tomography

PROJECT_TITLE: Elucidating underlying mechanisms in RIPK2-mediated toxicity following exposure to radiation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 IMMA-G (01)]


NIH_SPENDING_CATS: Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

ORG_STATE: NJ

PHR: NARRATIVE A deadly lung disease caused by Mycobacterium abscessus, a cousin of the bacterium that causes tuberculosis, is becoming more prevalent worldwide, particularly in aging and immunocompromised individuals. Currently available therapies often fail to achieve cure due to the intrinsic resistance of M. abscessus to most approved antibiotics, several of which have serious side effects and must be injected. Here we propose to discover and optimize new medicines and better combine existing ones to improve the treatment of M. abscessus lung disease.

PI_NAMEs: DICK, THOMAS  (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Academic support;Acceleration;Achievement;Address;Aging;Amides;Amoxicillin;analog;Antibiotics;Antimycobacterial Agents;Bacteria;bactericide;beta-Lactams;Biological;Biological Availability;biomarker validation;Bronchiectasis;Businesses;Cell Physiology;Chemicals;Chemistry;Chronic Obstructive Pulmonary Disease;Clinical;clinical candidate;clinical development;Clinical Trials;Collaborations;Collection;Communities;Complex;Couples;Cystic Fibrosis;Development;Disease;DNA-Directed RNA Polymerase;drug candidate;Drug Combinations;drug development;drug discovery;Drug Exposure;Drug Kinetics;Drug Targeting;Drug usage;Enzymes;Exhibits;Funding;Goals;Growth;Immune;Immunocompetent;Immunocompromised Host;immunodeficiency;improved;In Vitro;in vivo;Incidence;Individual;Infection;Inhalation;inhibitor;Injectable;innovation;Investigation;Knowledge;Lactams;Lead;lead optimization;Libraries;Ligands;Lung;Lung Diseases;Lung infections;machine learning algorithm;Medicine;Microbiology;Modeling;mouse model;Moxifloxacin;Mus;mycobacterial;Mycobacterium abscessus;Natural Resistance;Nature;Necrotic Lesion;non-tuberculosis mycobacteria;novel;Oral;pathogen;Patients;Penetration;Peptidoglycan;Periodicity;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;Pharmacology;Phenylalanine;Plasma;pre-clinical;preclinical development;preservation;Prevalence;Productivity;programs;Publishing;Regimen;Resistance;Ribosomal RNA;Rifabutin;Rifamycins;RNA Polymerase Inhibitor;rRNA Precursor;SCID Mice;Series;side effect;Site;Sterilization;success;synergism;Testing;Thinness;tool;Transcript;trial readiness;Tuberculosis;tuberculosis drugs;Vertebral column;Work

PROJECT_TITLE: Discovery of novel lead-target pairs and identification of all-oral bactericidal drug regimens for Mycobacterium abscessus lung disease

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


NIH_SPENDING_CATS: Cancer

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: Narrative of the Parent Grant The bioactive lipid, ceramide has very important roles in many pathological contexts including cancer and diabetes. Ceramide synthase (CerS) enzymes are crucial for ceramide production, however the basic molecular mechanisms of their regulation is largely unknown. The goal of this proposal is to establish and understand the molecular mechanisms of CerS1 regulation by Hsp27, and therefore will provide the knowledge for designing innovative therapies against cancer and other pathologies in which ceramide is implicated by identifying new methods to modulate CerS1 activity.

PI_NAMEs: SENKAL, CAN EMRE (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Applications Grants;Area;Biochemical;Biological;Biology;cancer cell;Cell Death;Cells;Ceramides;Charcot-Marie-Tooth Disease;Chemoresistance;chemotherapy;Data;design;Diabetes Mellitus;dihydroceramide desaturase;Disease;Down-Regulation;Enzymes;gain of function;Generations;Goals;Growth;Heat shock proteins;In Vitro;Induction of Apoptosis;inhibitor;Innovative Therapy;Knowledge;Link;Lipids;loss of function;Malignant Neoplasms;MAP Kinase Gene;Mediating;Mediator;Metabolism;Methods;Mitochondria;Molecular;Mutation;neuron development;Neurons;novel;novel therapeutics;p38 Mitogen Activated Protein Kinase;parent grant;Pathologic;Pathology;Pathway interactions;Phosphorylation;Play;Process;Production;Prognosis;protein protein interaction;Proteins;Proteomics;PUVA Photochemotherapy;Regulation;response;Role;Scheme;Signal Transduction;Small Interfering RNA;Sphingolipids;Tertiary Protein Structure;Testing;Therapeutic;tumor growth;Vertebral column

PROJECT_TITLE: Regulation of Ceramide Synthase by Protein-Protein Interaction