NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Cardiovascular;Clinical Research;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: PROJECT NARRATIVE Kawasaki Disease (KD) is an increasingly recognized, potentially fatal illness of young childhood that is the most common cause of acquired heart disease in children in the developed world. The most likely cause is an infection in genetically susceptible children, but the etiology has eluded 50 years of study, hampering the development of a diagnostic test and specific therapies. We have found that children with KD make antibodies against a specific protein. In this proposal we will identify more proteins that children with KD make antibodies against, determine whether these proteins are all present in one causative agent of KD or in multiple different causes, and develop assays for specific antibody responses to KD. These studies could have a major impact on the field of pediatrics by enabling improved diagnosis, treatment, and prevention of KD.

PI_NAMEs: ROWLEY, ANNE H (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Amino Acid Substitution;Antibodies;Antibody Response;Antigen Targeting;Antigens;Autoantigens;Binding;Biological Assay;bronchial epithelium;cDNA Library;Cells;Cessation of life;Child;Childhood;Clinical;Clonal Expansion;Coronary Aneurysm;Data;detection assay;Developed Countries;Development;Diagnosis;diagnostic assay;Diagnostic tests;Disease;Enzyme-Linked Immunosorbent Assay;Epidemiology;Epitopes;Etiology;Fever;Future;Geographic Locations;Goals;Health Care Costs;Heart Diseases;High-Throughput Nucleotide Sequencing;Human;Immune response;Immune Targeting;immunogenic;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunoglobulins;improved;Inclusion Bodies;Infant;Infection;Investigation;laser capture microdissection;Libraries;Mass Spectrum Analysis;Messenger RNA;Monoclonal Antibodies;Mucocutaneous Lymph Node Syndrome;Myocardial Infarction;novel therapeutics;Nucleic Acids;Pathogenesis;Patients;Pediatrics;Peptides;peripheral blood;Phage Display;Plasmablast;Predisposition;Prevention;Protein Array;protein purification;Proteins;response;Reverse Transcriptase Polymerase Chain Reaction;Risk;RNA;RNA Sequences;screening;Serology;Serology test;Sorting;Testing;Time;Tissues;Viral;viral detection;Virus;Western Blotting

PROJECT_TITLE: Identifying Specific Antigenic Targets of Kawasaki Disease

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE While emerging evidence suggests the heterogeneous nature of cell populations and time-varying signal transduction are essential to determine cellular responses to stimuli, most studies rely on conventional one-time measurements of bulk cells. We will rigorously investigate cellular heterogeneity, dynamics, and inheritability in migration with the help of high-throughput microfluidic single-cell tracking and selective retrieval, focusing on the CXCL12-CXCR4/ACKR3 axis as a model. The technology and paradigm we establish will be widely applied to elucidate cellular heterogeneity and dynamics in other contexts.

PI_NAMEs: CHEN, YU-CHIH  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: angiogenesis;Biological Markers;cancer cell;cell dimension;cell motility;Cells;Characteristics;Chemotaxis;Cues;CXCR4 gene;Data;Ear;Embryonic Development;Failure;Goals;Heterogeneity;image processing;In Vitro;in vivo;Individual;Inflammation;Inflammatory Response;Inherited;injury and repair;intravital microscopy;Liquid substance;Measurement;Microfluidics;migration;Migration Assay;Modeling;Molecular;molecular dynamics;Motility;Movement;multi-photon;Mus;Nature;Neoplasm Metastasis;Organelles;Pattern;Physiological Processes;Population;Process;Reporter;response;Retrieval;Robotics;Signal Transduction;single cell analysis;Skin;Speed;Stimulus;Stromal Cell-Derived Factor 1;Technology;Testing;therapeutic target;Time;Tissues;transcription factor;treatment duration;wound healing

PROJECT_TITLE: Deciphering Cellular Heterogeneity and Inheritability in Migration

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Narrative: Metaplastic breast cancer (MpBC) is an exceedingly rare and highly lethal subtype of breast cancer, and the main therapeutic option for metastatic MpBC remains systemic chemotherapy, despite known resistance to most chemotherapy drugs. Given the current lack of any effective treatment regimens, we propose a multi-center clinical trial to test the efficacy of a targeted approach combining inhibition of two major pathways implicated in MpBC, namely the phosphoinositide 3-kinase (PI3K/AKT) and nitric oxide synthase (NOS) pathways. Our proposal will further investigate the mechanism of this treatment, identify biomarkers of resistance, and assess interactions between various cells in the tumor and its environment using specimens derived from the MpBC patients in the trial.

PI_NAMEs: CHANG, JENNY C-N (contact);MERIC-BERNSTAM, FUNDA ;WONG, STEPHEN TC

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: 3-Phosphoinositide Dependent Protein Kinase-1;Accounting;Acetates;alpelisib;Apoptosis;Arginine;Automobile Driving;biomarker identification;Blood;Breast Cancer cell line;Breast Cancer Patient;Cancer Center;cancer stem cell;Cell Communication;cell growth;Cell Maintenance;Cells;Chemoresistance;chemotherapy;clinical center;Clinical Trials;combinatorial;Core Biopsy;Cytotoxic agent;Data;Data Analyses;Development;Disease;Dose;Drug resistance;drug resistance development;druggable target;Ecosystem;effective therapy;efficacy evaluation;efficacy testing;Endocrine;Enrollment;Environment;Epidermal Growth Factor Receptor;Epithelium;Estrogen Receptors;Exhibits;Fulvestrant;gain of function;Growth;Health;hormone receptor-positive;hormone therapy;Human;imaging system;Immunofluorescence Immunologic;inhibitor;intercellular communication;Investigation;Lead;Ligands;Lymphoid Cell;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Mesenchymal;Metaplastic carcinoma of the breast;Metastatic Neoplasm to the Lung;Methodist Church;Modeling;Molecular;Multi-Institutional Clinical Trial;Multicenter Trials;multimodal data;Mutate;Mutation;Myeloid Cells;National Cancer Institute;Nature;neoplastic cell;Nitric Oxide;Nitric Oxide Synthase;Nitric Oxide Synthetase Inhibitor;NOS2A gene;objective response rate;omega-N-Methylarginine;Oncogenic;Outcome;Paclitaxel;Pathway interactions;Patient-derived xenograft models of breast cancer;Patients;Pattern;Pharmaceutical Preparations;Phase;phase 2 study;Phase II Clinical Trials;Phosphatidylinositols;Phosphotransferases;PIK3CA gene;Postmenopause;pre-clinical;Process;Production;Progesterone Receptors;Prognosis;Progression-Free Survivals;Proto-Oncogene Proteins c-akt;PTEN gene;Publishing;Radiation therapy;rare cancer;receptor;Refractory;Regimen;Research;Resistance;Resources;response;Ribosomal Proteins;Role;secondary outcome;Signal Pathway;Signal Transduction;small molecule;Specimen;stem cell population;stem cell self renewal;stemness;Stromal Cells;Survival Rate;System;taxane;TdT-Mediated dUTP Nick End Labeling Assay;Testing;Therapeutic;therapeutically effective;therapy resistant;Tissues;transcriptomics;Translating;Treatment Efficacy;Treatment Protocols;treatment response;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;tumorigenesis;United States National Institutes of Health;University of Texas M D Anderson Cancer Center;Yam - dietary

PROJECT_TITLE: A phase II multi-center trial evaluating dual targeting of the PI3K/AKT and NOS pathways for treating metaplastic breast cancer (MpBC)


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: PORTLAND

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative  Glaucoma is a neurodegenerative disease of the optic nerve that is the leading cause of irreversible blindness worldwide and will affect 76 million people by the year 2020. Lowering intraocular pressure is the only available strategy to slow the progression of glaucomatous vision loss, but is not always successful in preventing blindness. This proposal will address the role of optic nerve head astrocyte reactivity in glaucomatous axon loss, as well as astrocyte modulation as a novel strategy for axon protection, with the ultimate goal of bringing to light new therapeutic targets to reduce the burden of glaucomatous vision loss worldwide.

PI_NAMEs: LOZANO, DIANA DEL CARMEN;MORRISON, JOHN C (contact);SIVYER, BENJAMIN M

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Actins;Acute;Adult Children;Affect;Animals;anterior chamber;Astrocytes;Attenuated;Axon;axon injury;axonal degeneration;Biological;Blindness;Cannulations;Communication;Connexin 43;Connexins;Cytoskeletal Proteins;Cytoskeleton;Data;Development;Disease;Event;fasudil;Future;Gap Junctions;Genes;genetic approach;genetic manipulation;Glaucoma;glial activation;Glial Fibrillary Acidic Protein;Goals;Hour;Human;Immunofluorescence Immunologic;Immunofluorescence Microscopy;in vivo;innovation;insight;Intermediate Filaments;kinase inhibitor;Knock-out;Knockout Mice;Label;light microscopy;LIM Domain Kinase 1;Link;LoxP-flanked allele;Mediating;Metabolic;Microfilaments;Modeling;modifiable risk;Molecular;Morphology;mouse model;Mus;Neurodegenerative Disorders;Neuroglia;neuroprotection;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Optic Disk;Optic Nerve;optic nerve disorder;Patients;Persons;pharmacologic;Physiologic Intraocular Pressure;prevent;Rattus;Reaction;response;Rho-associated kinase;Risk Factors;RNA Interference;Rodent;Rodent Model;Role;Site;small molecule;small molecule inhibitor;Tamoxifen;Techniques;Testing;Therapeutic;therapeutic target;Time;Tissues;tool;treatment strategy;Work

PROJECT_TITLE: Modulation of optic nerve head astrocyte reactivity in glaucoma

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Chronic Obstructive Pulmonary Disease;Clinical Research;Genetics;Human Genome;Lung;Precision Medicine;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Chronic obstructive pulmonary disease (COPD) is a major public health problem that is strongly influenced by cigarette smoking and genetic predisposition. The primary objectives of this proposal are to identify new protein biomarkers for COPD by studying large numbers of lung tissue samples, to determine the genetic determinants of these protein biomarker levels, and to integrate protein biomarkers, genetic variants, gene expression levels, and epigenetic marks to identify biological networks related to COPD pathogenesis. Identification and investigation of novel protein biomarkers may lead to new insights into the biological mechanisms causing COPD, suggest new pathways for treatment, and provide tools to select subjects for future clinical trials of COPD medications.

PI_NAMEs: MORITZ, ROBERT L;SILVERMAN, EDWIN K (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Address;Affinity;Airway Disease;Biological;Biological Markers;Blood;cell type;Cells;Chronic Obstructive Pulmonary Disease;cigarette smoking;Clinical;Clinical Trials;clinically relevant;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Data;Detection;Development;disease heterogeneity;Disease susceptibility;disorder subtype;DNA Methylation;drug development;Environmental Risk Factor;Epigenetic Process;Evaluation;Future;Gene Expression;Genes;Genetic;genetic analysis;genetic association;Genetic Determinism;Genetic Diseases;Genetic Predisposition to Disease;genetic variant;Genome;genome sequencing;genome wide association study;genome-wide;genome-wide analysis;Genomic Segment;Grant;Heterogeneity;Image;insight;Investigation;Lead;Lung;Machine Learning;Mass Spectrum Analysis;Measures;Mediation;Minority;Monitor;Multiomic Data;multiple omics;Network-based;novel;Pathogenesis;Pathway Analysis;Pathway interactions;Pharmaceutical Preparations;Plasma;Plasma Proteins;Play;Post-Translational Protein Processing;protein biomarkers;Proteins;Proteome;Proteomics;Public Health;Pulmonary Emphysema;Quantitative Trait Loci;Reaction;Research;Resolution;Role;Sample Size;Sampling;Single Nucleotide Polymorphism;Smoker;Stratification;Structure of parenchyma of lung;Subjects Selections;Technology;Testing;Tissue Sample;Tissues;tool;Trans-Omics for Precision Medicine;transcriptome sequencing;transcriptomics;Validation;whole genome

PROJECT_TITLE: COPD Susceptibility, Heterogeneity, and Progression: Proteomics and Genetics

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: Newark

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Given the overwhelming burden of HIV among Black men who have sex with men (BMSM) in Southern Ending the HIV Epidemic in the U.S. (EHE) jurisdictions, there is a need for innovative, culturally-relevant, and accessible interventions to promote their HIV-related health. The present hybrid type 2 implementation- effectiveness trial will evaluate THRIVE365, a multicomponent HIV intervention designed by BMSM for BMSM living with HIV in the Southern U.S. and facing intersectional stigma and multilevel barriers to HIV care. We will examine the daily and longer-term HIV-related behavioral and psychological health impacts, stigma moderating effects, and the maintenance and reach of THRIVE365 through a 6-month trial with 350 BMSM living with HIV in four Atlanta-area EHE jurisdictions.

PI_NAMEs: ENGLISH, DEVIN  (contact);SMITH, JUSTIN CHARLES

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Address;antiretroviral therapy;Anxiety;anxiety symptoms;Area;arm;Behavioral;behavioral health;behavioral outcome;black men;black men who have sex with men;Caring;Collaborations;combat;Communities;community based participatory research;community organizations;depressive symptoms;diaries;Economics;effective intervention;Effectiveness;effectiveness testing;effectiveness/implementation trial;Elements;emotion dysregulation;emotion regulation;empowerment;Ensure;Epidemic;Evaluation;evidence base;Evidence based intervention;experience;Fostering;Funding;Health;Health behavior;Health education;Health Promotion and Education;Healthcare;HIV;HIV diagnosis;HIV disparities;Housing;Hybrids;implementation design;improved;improved outcome;Individual;Inequity;innovation;Institution;Intervention;Leadership;Link;Maintenance;member;Mental Health;Mental health promotion;Methods;Modeling;Monitor;Motivation;multi-component intervention;multidisciplinary;National Institute of Mental Health;Outcome;Pathway interactions;Patient Self-Report;pilot trial;Population;primary outcome;psychologic;psychological outcomes;Race;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Research Personnel;research study;Resource-limited setting;Running;secondary outcome;Service delivery model;sexual minority;skills;social capital;Social isolation;social stigma;Social support;Social Work;substance use;Testing;theories;therapy design;Time;Transportation;treatment adherence;trend;Unsafe Sex;uptake;Waiting Lists

PROJECT_TITLE: Examining a Multicomponent Intervention to Improve HIV Health among Black Men in Southern Ending the HIV Epidemic in the U.S. Jurisdictions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-W(50)R]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Dissemination and Implementation Research;Health Services;Heart Disease;Infectious Diseases;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_STATE: IL

PHR: Project Narrative Respiratory syncytial virus is very common, but for some children born with special health care needs, including congenital heart disease, chronic lung disease of prematurity, and prematurity, infection can lead to significant and costly morbidity and mortality. While a preventive treatment is available to these high-risk infants, approximately two-thirds do not receive it. This research will provide new understanding about factors associated with receiving this preventive treatment and the ethical trade-offs that must be considered in the development of preventive policy, and ultimately will use a mixed methods approach to converge the quantitative and qualitative findings to prioritize barriers and facilitators to implementation of respiratory syncytial virus prevention policy.

PI_NAMEs: SAPER, JENNIFER KUSMA (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: 2 year old;Active Learning;Address;Admission activity;Asthma;Award;Black race;Bronchopulmonary Dysplasia;career;career development;Caring;Cessation of life;Child;Childhood;Clinical Investigator;Clinical Trials;Communication;congenital heart abnormality;Consolidated Framework for Implementation Research;Contracts;cost;cost effective;Cost Effectiveness Analysis;Data;Development;Development Plans;Diagnosis;Dose;Educational workshop;Eligibility Determination;Emergency department visit;Environment;Equity;Ethics;Ethnic Origin;Evaluation;evidence base;experience;Face;Foundations;Funding;Future;future implementation;Geography;Goals;Guidelines;health care availability;health inequalities;Health Policy;Health system;Healthcare;Healthcare Systems;hemodynamics;high risk;high risk infant;Hispanic;Hospitalization;Hospitals;immunoprophylaxis;implementation barriers;implementation facilitators;implementation science;Improve Access;improved;Infant;Infection;Injections;Inpatients;Institution;Insurance;Insurance Coverage;Knowledge;Learning;Life;Medicaid;Mentors;Mentorship;Methods;Modeling;Monoclonal Antibodies;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Palivizumab;passive immunoprophylaxis;Patients;Pediatric Hospitals;pediatrician;Physicians;Policies;Population;premature;Premature Infant;prevent;Prevention;Preventive;preventive intervention;Preventive therapy;Preventive treatment;prior authorization;Process;Prophylactic treatment;Provider;provider factors;public health insurance;Race;Research;Research Infrastructure;Research Personnel;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Risk;Seasons;skills;Specialist;System;tool;Training;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: RSV I-PREP: Improving Evidence-Based Implementation of RSV Immuno-Prophylaxis Within Ethical and Policy Contexts

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Breast Cancer;Burden of Illness;Cancer;Cervical Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Lung;Lung Cancer;Obesity;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative Women who identify as bisexual, lesbian, or queer have lower rates of breast and cervical cancer screening, but no large-scale data is available to understand the implications of these differences on cancer burden. In this project, we will better characterize breast and cervical cancer screening disparities by sexual identity and simulate the expected burden of cancer given current knowledge on risk behaviors and screening patterns. This research will provide much needed estimates of stage-specific cancer incidence and mortality, as well as provide actionable insights on upstream determinants affecting cancer screening use and breast and cervical cancer risk among sexual minority women.

PI_NAMEs: SPENCER, JENNY  (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Address;Affect;Alcohol consumption;Award;Behavior;Bisexual;Breast Cancer Detection;Breast Cancer Epidemiology;Breast Cancer Risk Factor;Calibration;Cancer Burden;cancer care;cancer risk;care providers;care systems;career;Caring;causal model;cervical cancer prevention;Cervical Cancer Screening;Contraceptive Usage;Data;Decision Modeling;Disease;Disparity;econometrics;Education;Epidemiology;Equation;Etiology;Frequencies;gender minority group;Goals;Health;health disparity;health equity;health inequalities;Health Services Accessibility;Heavy Drinking;Heterosexuals;High Prevalence;hormonal contraception;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papillomavirus;improved;Incidence;Inequity;insight;Insurance;Intervention;Knowledge;large scale data;Lesbian;Lesbian Gay Bisexual;Low Prevalence;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mediating;Mediator;medical schools;Mentorship;Methodology;Methods;Modeling;models and simulation;modifiable risk;mortality;National Health Interview Survey;Natural History;neoplasm registry;Nulliparity;Obesity;Oncogenic;Outcome;parity;Patient Self-Report;Pattern;perceived discrimination;Physical activity;Population;Poverty;Prevalence;Preventive care;Process;queer;racial disparity;Recommendation;Reporting;Research;Research Personnel;Resources;Risk Behaviors;Risk Factors;Role;screening;Screening for cancer;screening guidelines;Sex Orientation;sexual disparity;sexual identity;sexual minority;sexual minority group;sexual minority health;sexual minority men;sexual minority women;Smoking;social;social determinants;Source;Structure;Time;Training;tumor progression;Underserved Population;Update;uptake;wellness visit;Woman;Work

PROJECT_TITLE: Characterizing Breast and Cervical Cancer Burden Among Sexual Minority women


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narratives GBM is heavily infiltrated by tumor promoting macrophage through mechanisms still poorly understood. We have now identified two key therapeutic targets (LOX and TBK1) involved in macrophage recruitment and polarization, respectively, and preclinical therapeutic trials will be performed following detailed mechanistic characterization of novel LOX and TBK1 pathways.

PI_NAMEs: WANG, Y. ALAN  (contact)

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: Adult;Antibodies;Behavior;bone;Bone Marrow;cancer cell;Cells;chemoradiation;Chemotactic Factors;chemotherapy;Clinical;Combined Modality Therapy;cytokine;Cytometry;Data;Development;Diagnosis;effective therapy;Exhibits;gain of function;Gene set enrichment analysis;Genetic;genomic profiling;Glioblastoma;Heterogeneity;Immune;immune checkpoint blockade;Immune response;immunosuppressive macrophages;In Vitro;in vivo;Infiltration;inhibitor;Knockout Mice;Knowledge;loss of function;Macrophage;Malignant neoplasm of brain;Mediating;migration;Modeling;Molecular;monocyte;mouse model;Mus;Mutation;neutralizing antibody;new therapeutic target;novel;novel therapeutic intervention;osteopontin;Pathway interactions;Patients;Phenotype;pre-clinical;preclinical trial;Process;Protein-Lysine 6-Oxidase;Proteomics;Proto-Oncogene Proteins c-akt;PTEN gene;PTK2B gene;Radiation therapy;recruit;Role;Sampling;Signal Pathway;Signal Transduction;Specimen;standard of care;Stromal Cells;Subgroup;System;TANK-binding kinase 1;Therapeutic;therapeutic target;Therapeutic Trials;therapeutically effective;transcriptome sequencing;transcriptomic profiling;transcriptomics;translational potential;translational study;tumor;tumor microenvironment;Tumor Promotion;Tumor-associated macrophages;Up-Regulation;Validation

PROJECT_TITLE: Developing Novel Therapeutic Approaches Targeting Macrophages in GBM

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Microbiome;Rare Diseases;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE HPV infection has been identified as a definite human carcinogen for oropharyngeal cancer, and people with HIV have a much higher rate of oral HPV infection and oropharyngeal cancer than the general population. The proposed research will examine the associations among oral microbiome, periodontal diseases, and oral HPV infection, as well as the immunological underpinnings of oral HPV infection for people with HIV. The findings may indicate new biomarkers and novel therapeutic targets for preventing and managing oral HPV infection.

PI_NAMEs: FLOWERS, LISA C.;XIAO, CANHUA  (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Address;Affect;African American;Age;antiretroviral therapy;Atlases;Attitude;Behavior Disorders;Biological Markers;cancer therapy;cancer type;Carcinogens;Carcinoma;Caring;Cells;Cohort Studies;Communities;Complex;dysbiosis;Eligibility Determination;Environment;Epithelium;Etiology;federal poverty level;Flow Cytometry;follow-up;Functional disorder;General Population;Goals;Head and Neck Cancer;head and neck cancer prevention;Health;health care service;high dimensionality;HIV;HIV diagnosis;HIV Infections;Human;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immune;immune activation;Immune response;Immunologics;immunoregulation;Impairment;improved;Incidence;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;insight;Intervention;Lead;Link;Malignant Neoplasms;malignant oropharynx neoplasm;Mediating;Metagenomics;microbial;microbiome;microorganism;Mouth Diseases;Mucosal Immunity;Neighborhoods;new therapeutic target;novel sequencing technology;Oral;oral cavity epithelium;Oral Examination;oral HPV;oral HPV infection;oral HPV-positive head and neck cancers;oral infection;oral microbial community;oral microbiome;Oral mucous membrane structure;Outcome;Participant;Pathogenicity;Pathologic;Pathway interactions;Patients;Penetration;Periodontal Diseases;Persons;Play;Population;Predisposition;Prevalence;prevent;Prognosis;Recommendation;reconstruction;recruit;Recurrence;Reduce health disparities;Research;Resources;Role;Secondary to;social determinants;social health determinants;Solid Neoplasm;Survival Rate;Testing;Tight Junctions;Tissues;transcriptome sequencing;treatment comparison;Virus;Virus Diseases;virus related cancer

PROJECT_TITLE: Oral microbiome and periodontal diseases in oral HPV infection among people living with HIV


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Substance use disorders are difficult to treat because they hijack many of the neural mechanisms used in natural reward processing. I propose using recently developed state-of-the-art techniques for recording and analyzing the interactions of large populations of neurons to better understand the computational code behind population neural activity. These finer precision tools will allow us to identify better targets for therapeutic intervention in treating substance use disorders that leave natural reward-seeking behaviors intact.

PI_NAMEs: NIEH, HORNG-AN EDWARD (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Affect;Algorithms;Anatomy;Animal Behavior;Animals;Appetitive Behavior;Area;Behavior;Behavioral;Brain;Calcium;cell type;Cells;Characteristics;Chronic;Cocaine;cocaine seeking;Code;Complex;Computer Models;Computing Methodologies;Data;Decision Making;Detection;dimension reduction;Dimensions;Dorsal;drinking;Drug Addiction;Drug Modelings;drug seeking behavior;Exhibits;experimental study;feeding;Female;Food;Goals;Head;Heterogeneity;high dimensionality;Hippocampus;Hypothalamic structure;Image;Imaging technology;Implant;Individual;Indwelling Catheter;Injections;instrumentation;interest;Intervention;Lateral;Learning;Left;lens;Light;Location;male;Measures;Methods;microscopic imaging;Modeling;Mus;Nature;neural;neuromechanism;Neurons;Noise;novel;Optics;optogenetics;Pattern;Pharmaceutical Preparations;Phase;place fields;Population;programs;Research;Resolution;reward processing;Rewards;Rodent;Role;Self Administration;sex;Sex Behavior;Sex Differences;side effect;skills;Social Interaction;Substance Use Disorder;targeted treatment;Technical Expertise;Techniques;Technology;Testing;Therapeutic Intervention;tool;Training;two-photon;virtual reality

PROJECT_TITLE: Characterizing the underlying population code to understand the functional organization of the hippocampus and the lateral hypothalamus


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Muscular Dystrophy;Rare Diseases

ORG_CITY: CHESTNUT HILL

ORG_DEPT: BIOLOGY

ORG_NAME: BOSTON COLLEGE

PHR: Project Narrative Progress in treatment of impaired muscle function is limited in part by relatively poor understanding of the principles that govern the development of these specialized cells. One unique and dramatic feature of skeletal muscle cell development is the energetically expensive, long range movements of nuclei that establish myodomains with individual nuclei regulating each. The proposed research will identify the mechanisms that drive nuclear movement, the mechanisms that maintain nuclear spacing during muscle growth, and connect these mechanisms to muscle disease.

PI_NAMEs: FOLKER, ERIC S (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TITLE: The mechanisms and functions of nuclear spacing in muscle development

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Women's Health Research

ORG_DEPT: PEDIATRICS

PHR: Project Narrative-Relevance to Public Health Tumor-infiltrating regulatory T cells (Tregs) suppress effective immunity against breast tumors. We propose to develop a novel morpholino-based drug to direct FOXP3S isoform expression in Tregs and test its efficacy in breast cancer immunotherapy. This research will integrate Treg functions into precision medicine to fuel exciting translational development in breast cancer immunotherapy.

PI_NAMEs: OPYRCHAL, MATEUSZ ;ZHANG, XINNA ;ZHOU, BAOHUA  (contact)

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: Adoptive Cell Transfers;Adverse effects;Alternative Splicing;anti-tumor immune response;Asthma;Autoimmune Diseases;Autoimmunity;Bioinformatics;Birth;Breast Cancer Model;Breast Cancer Treatment;Cancer Biology;cancer genomics;cancer immunotherapy;cancer therapy;cancer type;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Clinical;clinical development;Data;Development;directed differentiation;Disease;Duchenne muscular dystrophy;efficacy evaluation;efficacy testing;Elements;Exhibits;Exons;FDA approved;FOXP3 gene;Gene Expression;Homeostasis;Human;human disease;Hypersensitivity;IL2 gene;Immune;Immune checkpoint inhibitor;Immune system;Immunity;Immunology;Immunosuppression;In Vitro;in vivo;Infiltration;Inflammation;Injections;Interferon Type II;Knock-in;Knock-out;Length;Malignant Breast Neoplasm;Mammary Neoplasms;Mediating;Messenger RNA;Modeling;mouse model;mRNA Expression;Mus;Mutant Strains Mice;neoantigens;neoplastic cell;novel;novel therapeutic intervention;Organoids;Outcome;patient derived xenograft model;patient subsets;Patients;Pharmaceutical Preparations;Play;precision medicine;programs;Protein Isoforms;Public Health;Publications;Regulatory Element;Regulatory T-Lymphocyte;Research;Research Personnel;Resistance;RNA Splicing;Role;Science;Severities;success;Systemic Lupus Erythematosus;T cell therapy;T-Cell Development;T-Lymphocyte;targeted treatment;Testing;The Cancer Genome Atlas;Toxic effect;transcriptomics;Transgenic Organisms;tumor;tumor growth;Tumor Immunity;Tumor Promotion;Wild Type Mouse

PROJECT_TITLE: Targeting FOXP3 mRNA splicing for breast cancer immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIR-W(01)Q]


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Digestive Diseases;Immunotherapy;Inflammatory Bowel Disease

ORG_DEPT: UROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Immune checkpoint inhibitor (ICI) therapy induced colon toxicity is a significant clinical problem for cancer patients. Current management of ICI-induced colitis (ICI-colitis) is empirically adopted from the management of autoimmune colitis/inflammatory bowel diseases, which has significantly interfered with the course of ICI-therapy. This proposed study aims to define new management strategies of ICI-colitis based on scientific rationales through a perpetual dialog between information derived from clinical sample and novel pre-clinical ICI-colitis animal models. We hope the outcome will help to improve the benefit of ICI therapy.

PI_NAMEs: SOSMAN, JEFFREY A;WU, JENNIFER D (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Address;Adopted;Adrenal Cortex Hormones;Animal Model;anti-CTLA-4 therapy;anti-CTLA4;anti-PD-1;Antibodies;Antibody Therapy;Archives;Autoimmune;autoimmune inflammatory bowel disease;Biochemical;Biochemical Markers;Biopsy;cancer immunotherapy;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;checkpoint therapy;Circulation;Clinical;Clinical Trials;Code;cohort;Colitis;Colon;Colonic inflammation;cytotoxicity;Development;effective therapy;Enterocolitis;Failure;Genetic Engineering;Grant;Guidelines;Human;IL18 gene;Immune;immune activation;Immune checkpoint inhibitor;immune-related adverse events;immunoregulation;improved;Inflammatory Bowel Diseases;inflammatory milieu;Institution;integrin alpha4beta7;Integrins;Intestines;Ligands;Manuscripts;Mediating;Modeling;Molecular;molecular pathology;Molecular Profiling;molecular subtypes;Morbidity - disease rate;mouse model;Mus;novel;Oncogenic;Outcome;Pathway interactions;patient subsets;Patients;PD-1/PD-L1;Pilot Projects;pre-clinical;prevent;Production;Prostatic Neoplasms;Refractory;Reporting;Sampling;Science;Serum;Source;standard care;Steroids;TNF gene;Toxic effect;tumor;Work

PROJECT_TITLE: Pathway-guided treatment of immune checkpoint inhibitor therapy-induced colon toxicity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIO-D(01)Q]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hearing Loss;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PUBLIC HEALTH RELEVANCE Childhood hearing loss disproportionately affects low- and middle-income countries (LMICs), where up to 75% of cases are preventable due to the high prevalence of infection-related hearing loss. School hearing screening is critical for identification of childhood hearing loss in low resource settings, but most screening programs cannot identify middle ear disease that is widespread in populations with a high prevalence of infection-related hearing loss. This study will develop and validate an mHealth tympanometer with machine learning diagnostic support to transform this technology into a low-cost tool that could be broadly disseminated in LMICs.

PI_NAMEs: EMMETT, SUSAN DAVIS (contact);PALMERI, MARK L.;SWANEPOEL, DEWET

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Achievement;Address;Advocacy;Affect;Alaska;Algorithms;Audiology;Award;Caring;Cellular Phone;Child;Child Care;childhood hearing loss;Clinical;cloud based;Cluster randomized trial;Collaborations;Community Health Aides;Computer software;cost;Country;Data;Data Science;Data Scientist;Database Management Systems;Dedications;design;Development;Device Designs;Device or Instrument Development;Devices;Diagnostic;digital;Disparity;Ear;ear infection;early childhood;Ecosystem;Employment Opportunities;empowerment;Engineering;Environment;Evaluation;fabrication;Feasibility Studies;Feedback;Funding;Future;Goals;health information technology;Hearing;hearing impairment;hearing screening;High Prevalence;Impairment;improved;Individual;Infection;Information Systems;Infrastructure;innovation;International;Language Development;large datasets;low and middle-income countries;Machine Learning;machine learning algorithm;member;Methodology;Methods;mHealth;middle ear disorder;Neonatal Screening;Nursery Schools;Performance;Periodicity;Persons;Phase;Population;Preschool Child;Prevalence;Preventive healthcare;programs;prototype;Public Health;public health relevance;recruit;Research;Resource-limited setting;Risk;rural Alaska;school health;Schools;screening;screening program;Secure;Site;software development;Software Engineering;South Africa;South African;Tablets;teacher;Technology;technology development;Testing;tool;Training;Triage;Tympanometry;Universities;user centered design;Validation;validation studies;Widespread Disease;World Health Organization

PROJECT_TITLE: mHealth Tympanometer: A Digital Innovation to Address Preventable Childhood Hearing Loss in Low- and Middle-Income Countries


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: NEUROLOGY

PHR: This application has been developed in response to the NINDS RFA to renew our participation as a Clinical Site in the Network for Excellence in Neuroscience Clinical Trials (NEXT). Participation in NEXT will enable Northwestern University to contribute expertise and diverse research participants to neurological clinical trials across multiple subspecialties in adult and pediatric populations through its three major affiliated clinical facilities: Northwestern Memorial Hospital (NMH) with 11 affiliated hospitals, Ann & Robert H. Lurie Children’s Hospital of Chicago (LCH), and the Shirley Ryan Ability Lab (SRALab).

PI_NAMEs: SIMUNI, TANYA  (contact)

PROGRAM_OFFICER_NAME: OHAYON, JOAN M

PROJECT_TERMS: Adherence;Adult;Agreement;base;biomarker validation;career;Chicago;Childhood;Clinical;Clinical and Translational Science Awards;clinical biomarkers;Clinical Research;clinical research site;Clinical Sciences;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Conduct Clinical Trials;Data;data quality;design;Development;Discipline;Enrollment;Ensure;Equipment;experience;Faculty;Foundations;Funding;Future;Gender;Gene Delivery;gene therapy;Hospitals;Human Resources;human subject protection;Industry;industry partner;Infrastructure;Institution;Institutional Review Boards;Intervention Trial;Leadership;medical schools;member;Mentorship;Minority;Modeling;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurologic;Neurology;Neurosciences;next generation;novel;Participant;participant enrollment;participant retention;patient oriented;patient population;Patient Recruitments;Patients;Pediatric Hospitals;Performance;Phase;Phase II Clinical Trials;Population;Population Heterogeneity;pre-clinical;Privatization;programs;Protocols documentation;Qualifying;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Training;Resources;response;Role;Site;skills;Source;Standardization;Structure;success;Training;Translational Research;translational study;Translations;United States National Institutes of Health;Universities;validation studies;Work;working group

PROJECT_TITLE: Clinical Research Site for the Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT site)


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: HANOVER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: AIDS patients lose important T cell populations during the course of disease, making them susceptible to disease from herpesviruses that are normally latent within the patient. This proposal focuses on understanding immune surveillance against gammaherpesviruses, which can give rise to severe disease in AIDS patients. We will uncover the mechanisms responsible for maintaining long-term immune surveillance that may lead to better ways to restore T cell immunity to AIDS patients, thereby preventing gammaherpesvirus-associated disease.

PI_NAMEs: USHERWOOD, EDWARD J (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;acute infection;Affect;Apoptosis;B-Cell Lymphomas;B-Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Immunity;Cellular Metabolic Process;Chronic;chronic infection;Data;Defect;design;Development;Disease;Electron Transport;experience;experimental study;Failure;Family;gammaherpesvirus;Gene Expression Profile;Generations;Genes;genetically modified cells;Glycolysis;Growth;Herpesviridae;Herpesviridae Infections;HIV;Human;Human Herpesvirus 4;Human Herpesvirus 8;Immune;Immunity;immunodeficiency;Immunologic Surveillance;Immunotherapy;Impairment;improved;in vivo;Infection;insight;knock-down;Knowledge;Laboratories;latent infection;Lead;Left;long term memory;Lymphoma;Malignant Neoplasms;Mediating;Memory;Mental Depression;Metabolic;Metabolic Pathway;metabolic rate;Mitochondria;mitochondrial metabolism;Modeling;Molecular;mouse model;Mus;novel;pathogen;Pathway interactions;Patients;Population;Predisposition;prevent;Pyruvate Kinase;rational design;recruit;Respiration;respiratory;response;restoration;Rodent;Role;single-cell RNA sequencing;System;T cell differentiation;T cell regulation;T cell response;T-Lymphocyte;Testing;transcription factor;Transcription Repressor;transcriptomics;Virus;Virus Diseases;Virus Latency;Virus Replication;Work

PROJECT_TITLE: Dissecting immune surveillance to gammaherpesviruses

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurosciences;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative The prevalence of cigarette smoking among HIV-infected individuals is 2 to 3 times greater than in the general population, and smoking has deleterious effects on the long-term survival of these individuals. Chronic cigarette smoking and HIV infection may lead to additive or synergistic effects on the brain and cognitive deficits. The proposed research will develop a new magnetic resonance spectroscopy scan that allows robust measurements of brain chemicals to investigate the independent and combined impact of HIV infection and tobacco smoking on the human brain and enhance our understanding of the biochemical processes that may contribute to cognitive decline in HIV-infected smokers.

PI_NAMEs: SALEH, MUHAMMAD G (contact)

PROJECT_TERMS: Affect;Age;Aminobutyric Acids;Antioxidants;antiretroviral therapy;ascorbate;Aspartate;Basal Ganglia;Basic Science;Biochemical Process;Brain;brain health;Brain Injuries;Brain region;career;Cell membrane;cell type;Chemicals;Choline;Chronic;Cigarette;cigarette smoking;Clinical;clinical application;Clinical assessments;Clinical Data;Clinical Research;clinical training;Cognitive deficits;Complement;Complex;data acquisition;Development;Disease;Drug usage;Economic Burden;executive function;experience;experimental study;General Population;Glutamates;Glutathione;Goals;gray matter;Health;HIV;HIV Infections;Human;Impaired cognition;improved;Impulsivity;in vivo;Individual;interest;Investigation;Learning;Lipids;magnetic field;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measurement;Measures;Mentors;metabolic abnormality assessment;Metabolic Marker;Metabolism;Methodology;Methods;Mission;Morbidity - disease rate;Morphologic artifacts;mortality;Motion;N-acetylaspartate;N-acetylaspartylglutamate;National Institute of Drug Abuse;neurobiological mechanism;neurochemistry;Neurocognitive Deficit;neuroimaging;neuroinflammation;Neuromodulator;Neuronal Injury;Neurons;neuroregulation;neurotransmission;Neurotransmitters;Nicotine;Noise;novel;Oxidative Stress;Parietal;Participant;patient population;Patients;Persons;Phase;Pilot Projects;Prevalence;prospective;Protocols documentation;Protons;Psychopathology;Public Health;reconstruction;Reporting;Reproducibility;Research;Research Design;Research Proposals;Scanning;Scientist;sex;Short-Term Memory;Signal Transduction;skills;Smoker;Smoking;Socioeconomic Status;Spectrum Analysis;Standardization;Statistical Methods;System;Techniques;Technology;Tobacco;tobacco smokers;Tobacco smoking behavior;tool;Training;training opportunity;Vendor;Viral Load result;white matter;Work

PROJECT_TITLE: Neurometabolic profile of tobacco smoking in HIV-infected Individuals


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Childhood Injury;Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Neurosciences;Pain Research;Pediatric;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Concussion, or mild traumatic brain injury (mTBI) is a neurological disorder that causes disability in children and predisposes them to significant challenges later in life, though we do not yet have a reliable method of detection. In this program, we use advanced neuroimaging to evaluate the peripheral and central nervous system pathways that that innervate the eye and face with the hypothesis they are sensitive to mTBI. This first- of-its-kind study will provide invaluable information that can be applied towards the diagnosis, monitoring and treatment of persons with an mTBI and helping protect vulnerable populations.

PI_NAMEs: HOLMES, SCOTT ;MOULTON, ERIC ALAN (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Adolescent;Adopted;Adult;afferent nerve;Afferent Pathways;Area;base;Behavior;Brain;brain behavior;Brain Concussion;Brain imaging;Case Study;Central Nervous System;central sensitization;Child;Childhood;Clinical;clinical decision-making;Cognitive;cohort;Cornea;Craniocerebral Trauma;Data;density;detection method;Development;Diagnosis;diagnostic biomarker;Diffusion Magnetic Resonance Imaging;disability;Edema;Event;experience;Eye;Face;Functional disorder;Functional Magnetic Resonance Imaging;Growth;Headache;Health;Hypersensitivity;Image;improved;in vivo;Incidence;insight;interdisciplinary approach;Investigation;Length;Life;Light;light intensity;Masks;Measures;Mediating;Microscopy;mild traumatic brain injury;Monitor;multidisciplinary;Nerve;Nerve Fibers;nerve injury;Nervous System Disorder;Neural Pathways;Neurobiology;neuroimaging;neuroinflammation;Neurologic;Neuronal Plasticity;Nociception;Optometry;Organ;Pain;Pain Disorder;pain perception;pain symptom;Pain Threshold;Paper;Pathology;Pathway interactions;Patient Monitoring;Patients;pediatric traumatic brain injury;Peripheral;Peripheral Nervous System;Persons;Photophobia;Population;programs;psychologic;Psychology;Puberty;Radial;Reporting;Rest;Risk;Rodent;Role;Sensory;sensory input;Signal Transduction;Source;statistics;Structure;symptomatology;Symptoms;Testing;Trigeminal nerve structure;Trigeminal System;Visual;Visual Psychophysics;Vulnerable Populations;Work

PROJECT_TITLE: The trigeminal nociceptive-pain pathway in pediatric mTBI: peripheral and central contributions to photophobia

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Genetics;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

PHR: Project Narrative This research is necessary to understand the normal biology of the vasculature in the lung. Our findings will reveal new mechanisms that are relevant to pulmonary diseases and the long-term consequences of the failure of these processes.

PI_NAMEs: VILA ELLIS, LISANDRA  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Address;Adult;Affect;Alveolar;Alveolus;Appearance;Biology;Blood capillaries;Blood Vessels;Breeding;Bronchopulmonary Dysplasia;Cancer Center;Capillary Endothelial Cell;career;career development;cell fate specification;Cell Maturation;Cells;Congenital alveolar dysplasia;Data;Defect;Development;Developmental Biology;developmental disease;Disease;DNA;Embryo;Endothelial Cells;Endothelium;Ensure;Epithelial Cells;Epithelium;experience;Failure;Family;FOXF1 gene;Future;Gases;Genes;Genetic;Genetic Models;Genetic Transcription;Genomics;Heterogeneity;Human;Hyperoxia;Individual;Interruption;Link;Location;Lung;lung development;Lung Diseases;Mentors;Mesenchymal;Modeling;Morphology;mouse genetics;mouse model;Mus;mutant;Myofibroblast;Names;Neonatal Hyperoxic Injury;novel;Paper;Phase;Phenotype;Physicians;Physiological;Play;Population;Postdoctoral Fellow;postnatal;Predisposition;Premature Infant;Process;protein expression;Publishing;Pulmonary alveolar structure;Research;response;Retina;Role;Sampling;Scientist;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;SOX17 gene;Specific qualifier value;Surface;Testing;Three-Dimensional Imaging;Time;Tissues;TP53 gene;Training;transcription factor;vascular abnormality;Vascular System;VEGFA gene;Virus Diseases;Work

PROJECT_TITLE: Mechanism of pulmonary endothelial cell heterogeneity and its role in disease

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dementia;Disability Research;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases;Rehabilitation;Social Determinants of Health

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE: In the absence of a cure for neurodegenerative dementias, it is important to develop evidence-based interventions that maximize quality of life and independence with high potential for implementation. This trial will evaluate the efficacy of two interventions for individuals with primary progressive aphasia (PPA) delivered through synchronous videoconference sessions with asynchronous custom web-application activities. Outcomes from this trial will inform clinical guidelines for nonpharmacologic interventions for PPA, which can be adapted for other dementia syndromes.

PI_NAMEs: ROBERTS, ANGELA CHRISTINE;ROGALSKI, EMILY J (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: active control;Address;Alzheimer's Disease;Aphasia;arm;care giving burden;Caring;Clinical;clinical care;clinical practice;Clinical Trials;CNR1 gene;CNR2 gene;Communication;Communication difficulty;Communication impairment;Communities;Complex;cost;cost effectiveness;Cost Effectiveness Analysis;Counseling;Custom;Data;Dementia;Development;Disease;Economic Burden;Education;efficacy evaluation;Evaluation;Evidence based intervention;experimental arm;Family;Focus Groups;Frontotemporal Lobar Degenerations;functional outcomes;Future;Guidelines;health economics;inclusion criteria;Individual;innovation;Intervention;intervention cost;Interview;Language;language impairment;Life;Measurement;Measures;Modeling;neurodegenerative dementia;Neurodegenerative Disorders;neuropathology;Nonpharmacologic Therapy;novel;Outcome;Participant;Patients;personalized medicine;Persons;Phase;Physical activity;post intervention;Pragmatic clinical trial;pragmatic trial;predicting response;primary outcome;Primary Progressive Aphasia;Probability;Progressive Aphasias;psychosocial;Quality of life;Randomized, Controlled Trials;Readiness;remote patient monitoring;response;skills;social engagement;Social Interaction;Speech;success;Syndrome;Testing;Theoretical model;tool;Training;translational potential;trial design;trial readiness;videoconference;wearable sensor technology;web app;Work

PROJECT_TITLE: Communication Bridge: Optimizing an evidence-based intervention for individuals with primary progressive aphasia

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The secretion of fluid is a principal function of the intestine that is altered under conditions of stress, and infections to result in diarrhea. This proposal explores the cellular mechanisms responsible for fluid secretion in the intestine under the condition of stress and infections. This work will increase our understanding of how stress exacerbates diarrhea and identify targets for treatment.

PI_NAMEs: AMEEN, NADIA A. (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Affect;airway epithelium;Animal Model;Anions;Biological Assay;Biotinylation;Cell membrane;Cells;Cellular Stress;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cyclic GMP;Cyclic Nucleotides;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Development;Diarrhea;diarrheal disease;Electrophysiology (science);Endocrine;Enterocytes;Enterotoxins;Escherichia coli;Escherichia coli Infections;Etiology;Fluids and Secretions;Genetic;Genetic Transcription;Glucocorticoids;Human;Immunofluorescence Immunologic;in vivo;Infection;Inflammatory;interest;Intestines;Ion Transport;Irritable Bowel Syndrome;knock-down;Knockout Mice;Knowledge;Link;Mass Spectrum Analysis;Mediating;Mediator;Membrane Protein Traffic;Messenger RNA;Mineralocorticoids;mouse model;mRNA Expression;Mus;mutant;nerve stem cell;Neurosecretory Systems;new therapeutic target;novel;novel therapeutics;Pathway interactions;Phosphatidylinositols;Phosphorylation;Phosphotransferases;Physiologic pulse;Physiological;Population;protein expression;Rattus;Regulation;Role;Serum;Sgk protein;Signal Pathway;Signal Transduction;small hairpin RNA;Stains;stem;Stress;Surface;Testing;trafficking;Translations;ubiquitin ligase;Western Blotting;Work

PROJECT_TITLE: Glucocorticoid and SGK1 regulation of CFTR in the intestine: role in diarrhea

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


NIH_SPENDING_CATS: Cystic Fibrosis;Infectious Diseases;Lung;Nutrition;Rare Diseases

ORG_CITY: CAMBRIDGE

ORG_DEPT: CHEMISTRY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: NARRATIVE The bacterial pathogens Pseudomonas aeruginosa and Staphylococcus aureus are leading causes of morbidity in the United States; these pathogens co-infect immunocompromised patients, including diabetics and individuals with cystic fibrosis, and cause chronic polymicrobial infections. Transition metals are essential nutrients (e.g. iron, zinc) for all organisms, and the host innate immune system withholds these nutrients from bacterial pathogens to prevent infections. Elucidating how metal-sequestering innate immune proteins, such as calprotectin, affect the availability of nutrient metal ions and the physiology of P. aeruginosa and S. aureus under conditions relevant to disease has the potential to guide novel diagnostic and therapeutic approaches, ultimately improving the care and quality of life in diverse patient populations.

PI_NAMEs: NOLAN, ELIZABETH M (contact);OGLESBY, AMANDA GAIL

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;Aerobic;Affect;Antimicrobial Resistance;Applications Grants;bacterial genetics;Bacterial Infections;Bacterial Physiology;Binding;Biochemical;Bioinorganic Chemistry;Biological Availability;Caring;chelation;Chronic;chronic infection;Coculture Techniques;Collaborations;Communities;Complex;Cues;Cystic Fibrosis;cystic fibrosis patients;cystic fibrosis serum factor;Dehydration;design;Development;diabetic;Disease;Early identification;Environment;Epithelial Cells;Etiology;expectation;experience;Extracellular Space;Foundations;Funding;Future;Genetic;Goals;Growth;Hereditary Disease;Heritability;Heterogeneity;Homeostasis;Host Defense;Human;human pathogen;Hypoxia;Immune;Immune response;Immunity;Immunocompromised Host;improved;in vitro Model;Individual;Infection;Infection prevention;Innate Immune System;insight;Invaded;Investigation;Ions;Iron;Lactoferrin;Leukocyte L1 Antigen Complex;Life;Lung;Lung infections;Manganese;Metabolism;Metals;microbial;Microbial Biofilms;microbial community;microorganism competition;Modeling;Morbidity - disease rate;Mucous body substance;Natural Immunity;neutrophil;novel diagnostics;novel therapeutic intervention;Nutrient;Nutrient availability;Nutritional Immunity;Organism;Outcome;Oxygen;pathogen;Pathogenesis;pathogenic bacteria;pathogenic microbe;Pathogenicity;Pathway interactions;patient population;pH gradient;Physiology;prevent;Proteins;Pseudomonas aeruginosa;Pulmonary Cystic Fibrosis;pulmonary function;Quality of life;Reporting;Research;Research Proposals;response;Role;S100A12 gene;Site;Sputum;Staphylococcus aureus;Starvation;Structure;System;Testing;Therapeutic;Thick;Time;Transition Elements;United States;uptake;Virulence;Work;Zinc

PROJECT_TITLE: Metallobiochemistry of innate immunity and bacterial physiology

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Chronic Fatigue Syndrome (ME/CFS);Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Neurologic post-acute sequelae of SARS-CoV-2 (PASC) is an emerging threat. The trajectory and pathophysiology of PASC are poorly understood; however, underlying autoimmunity and persistent immune activation are suspected. This proposal aims to better characterize the sub-phenotypes and clinical course of neurologic PASC and to test for the role autoantibodies, persistent immune activation, and gut microbiota in a longitudinal cohort of COVID-19 survivors.

PI_NAMEs: PURPURA, LAWRENCE JAMES (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 2019-nCoV;ACE2;activin B;Acute;acute COVID-19;Acute Disease;acute infection;Affect;Antibiotics;Antibodies;Antigens;Autoantibodies;Autoimmunity;biobank;Biometry;career;CD8-Positive T-Lymphocytes;Centers for Disease Control and Prevention (U.S.);Chronic;Chronic Fatigue Syndrome;Clinical;Clinical Management;Clinical Research;Clinical Treatment;cohort;Cohort Studies;Communicable Diseases;comorbidity;Complication;COVID-19;COVID-19 pandemic;COVID-19 survivors;COVID-19 vaccine;cytokine;Data;demographics;design;Diagnostic;Disease Outbreaks;Dysautonomias;dysbiosis;Ebola;emerging pathogen;emerging virus;Environment;Epidemiology;epidemiology study;Etiology;experience;extracellular;Fatigue;Feces;Functional disorder;Funding;G-Protein-Coupled Receptors;gastrointestinal;Goals;Growth;gut microbiota;Heat shock proteins;HIV;HIV Infections;HIV-associated neurocognitive disorder;Human Herpesvirus 4;IL2 gene;Immune;immune activation;Immunology;Impaired cognition;Individual;Infection;Inflammation;innovation;insight;Integration Host Factors;Intelligence;Interferon Type II;Interferons;Intestinal permeability;Knowledge;Liberia;Link;Longitudinal cohort;Medical center;Medicine;Memory;Mentored Patient-Oriented Research Career Development Award;Mentors;microbial;microbiome;microbiome analysis;microbiota;multidisciplinary;Natural Killer Cells;Neurologic;neurologic sequelae of COVID-19;Neurologic Symptoms;novel;Nucleocapsid;Outcome;Participant;pathogen;Peripheral;Phase;Phenotype;Physicians;Positioning Attribute;Post-Acute Sequelae of SARS-CoV-2 Infection;Postural Orthostatic Tachycardia Syndrome;Predisposing Factor;prevent epidemics;prospective;Public Health;Relapse;Reporting;Role;Scientist;Services;Severe Acute Respiratory Syndrome;Severities;Severity of illness;Signal Transduction;skills;Specimen;Surveys;Survivors;Syndrome;Testing;Time;Training;transcriptome sequencing;Translational Research;trend;United States;Universities;Vaccination;Variant;Viral;Virus Diseases

PROJECT_TITLE: Evaluating the Epidemiology and Determinants of Neurologic Post-acute Sequelae of SARS-CoV-2

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: IRVINE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Macrophages are central regulators of inflammation and tissue repair processes, and their function is tightly controlled by cues in the surrounding microenvironment. The goal of the proposed research is to elucidate the molecular mechanisms underlying how tissue stiffness controls macrophage function. This work may open new strategies to modulate immune function during wound healing and disease.

PI_NAMEs: LIU, WENDY  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Actins;Adhesions;Biochemical;Biocompatible Materials;biophysical properties;Biophysics;Calcium;capsule;Cardiovascular Diseases;Cell Proliferation;Cell Shape;Cells;Cellular Infiltrate;chemokine;chronic inflammatory disease;cofactor;Cues;cytokine;Cytoskeletal Modeling;Cytoskeleton;Data;Disease;Engineering;Environment;Extracellular Matrix;Fibrosis;Functional disorder;Genetic;Genetic Transcription;Goals;healing;Homeostasis;Hydrogels;imaging approach;Imaging Device;immune function;Immune response;immunomodulatory strategy;immunoregulation;Implant;implant material;improved;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;Innate Immune System;Ion Channel;Knowledge;Macrophage;Macrophage Activation;Malignant Neoplasms;Measures;mechanical signal;Mechanics;Mediating;Mediator;Methods;Modeling;Molecular;monocyte;mouse model;Mus;new therapeutic target;novel;Nuclear;Nuclear Protein;Organ Size;pathogen;Permeability;pharmacologic;Phenotype;Piezo 1 ion channel;polymerization;Polymers;Population;Process;protein expression;Proteins;Regulation;Reporting;Research;Resolution;response;Role;Signal Pathway;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Solid;spatiotemporal;Stimulus;subcutaneous;synergism;Testing;tissue repair;Tissues;tool;Work;wound healing

PROJECT_TITLE: Biophysical regulation of macrophage function

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: TULSA

ORG_NAME: LAUREATE INSTITUTE FOR BRAIN RESEARCH

ORG_STATE: OK

PHR: PROJECT NARRATIVE: Overall The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) seeks 5 years of support to continue and expand the scientific infrastructure in Tulsa, OK, to help young investigators develop research projects focused on identifying biological causes and predictors of anxiety and mood disorders. Tulsa is still an under-developed region for mental health research even though Oklahoma has the second highest rate of mental illness in the country. The NeuroMAP Center will continue a program to train junior researchers with a pragmatic focus to use neuroscience to improve mental health.

PI_NAMEs: PAULUS, MARTIN P. (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: adaptive immunity;Anxiety;Anxiety Disorders;anxious individuals;Area;Arizona;avoidance behavior;Award;base;Behavior;Biological;Brain;career;career development;Categories;Cells;comorbidity;Computer Models;Country;Data;data management;data repository;Databases;diagnostic strategy;Diffusion Magnetic Resonance Imaging;Disabling;Disease;disease model;Emotional;Environment;exosome;Experimental Designs;Extramural Activities;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Grant;health assessment;Image;improved;Individual;Infrastructure;infrastructure development;Intervention;Laboratories;language processing;Left;Link;Medical;Mental Depression;Mental disorders;Mental Health;Mentors;Michigan;minority investigator;Mood Disorders;Myelin;National Institute of Mental Health;neural;neurofeedback;neuroimaging;Neurosciences;Oklahoma;Paper;Phase;Physiology;Pilot Projects;Postdoctoral Fellow;Prefrontal Cortex;Process;programs;Publishing;recruit;Recurrence;Relapse;Reporter;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Resources;Risk;Robin bird;Services;Severities;South Carolina;Standardization;statistics;Symptoms;Talents;Thinking;Time;tool;Training;transcranial direct current stimulation;Underrepresented Minority;United States National Institutes of Health;Universities;young adult


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: SEATTLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Cross-species transmission of pathogens is a major threat to public health worldwide and accounts for 75% of emerging human infectious diseases. Bats act as asymptomatic reservoir hosts for numerous zoonotic viruses, that are lethal in humans and for which no vaccines or specific therapeutics exist, indicating that the chiropteran immune system can control these viruses. The proposed project will illuminate the role of bat humoral immunity in controlling pathogen infections, identify novel therapeutics against zoonotic viruses and guide the computational design of next-generation protein inhibitors of viral entry.

PI_NAMEs: VEESLER, DAVID  (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Antibodies;B Cell Proliferation;Chiroptera;combat;combinatorial;Communicable Diseases;coping;cross-species transmission;design;fighting;Human;Humoral Immunities;Immune response;Immune system;Immunoglobulins;Infection;interest;Mammals;Molecular;Natural Immunity;next generation;novel therapeutics;pandemic preparedness;pathogen;Proteins;Public Health;Role;Source;Therapeutic;tool;Vaccines;viral entry inhibitor;Virus;Virus Inhibitors;Work;Zoonoses

PROJECT_TITLE: Unraveling the bat humoral immune response against zoonotic viruses to guide the design of next-generation therapeutics


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Mental Health;Neurosciences

PROJECT_TERMS: Address;Advisory Committees;Anxiety Disorders;Applications Grants;Award;base;Behavior;Biological;blood-based biomarker;Brain;Budgets;career;career development;Clinical assessments;Communities;Competence;Complex;computerized data processing;Consultations;Data;Data Analyses;Development;effectiveness research;Eligibility Determination;Ensure;Environment;Evaluation;experience;Faculty;Feedback;Fostering;Foundations;Funding;Future;Genetic;Grant;health assessment;Human Resources;improved;Infrastructure;infrastructure development;Institution;Institutional Review Boards;Laboratories;Leadership;Measures;meetings;Mental Health;Mentors;Mentorship;Modeling;Mood Disorders;neuroimaging;Neurosciences;Oklahoma;operation;organizational structure;Outcome;Persons;Phase;Pilot Projects;Process;Program Development;programs;Questionnaires;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;response;Risk;Robin bird;Standardization;Structure;success;Suggestion;Supervision;supportive environment;Talents;Testing;Thinking;Time Management;Training;training opportunity;Travel;United States National Institutes of Health;Universities;Update;virtual;Visit;Work

PROJECT_TITLE: NeuroMAP Phase II - Administrative Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Mental Health;Neurosciences

PI_NAMEs: AUPPERLE, ROBIN L (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Accounting;Address;Adult;Affect;Anxiety Disorders;Applications Grants;approach behavior;Arkansas;avoidance behavior;base;Behavior;Behavior assessment;Businesses;Cells;Cities;Common Core;Common Data Element;Data;Data Analyses;Data Collection;Databases;Development;Diagnosis;Diagnostic;Disease;DSM-V;Equilibrium;Extramural Activities;Fee-for-Service Plans;Formulation;Future;Goals;Guidelines;health assessment;Health Sciences;Individual;Infrastructure;Institution;instrument;Interoception;Interview;Leadership;Literature;Measures;meetings;Mental disorders;Mental Health;Mood Disorders;Moods;motivated behavior;Motivation;National Institute of Mental Health;negative affect;Negative Valence;Neurosciences;Neurosciences Research;novel;Oklahoma;operation;Participant;Patient Recruitments;Patient Self-Report;Performance;Phase;PhenX Toolkit;Physiology;Pilot Projects;Positive Valence;Procedures;Process;recruit;Reproducibility;Research;Research Domain Criteria;Research Personnel;Research Project Grants;research study;Research Support;Resources;response;screening;Severities;Signal Transduction;Standardization;Stimulus;Structure;Symptoms;System;Teenagers;Thinking;Training;United States National Institutes of Health;Universities;Update;Validation;Work

PROJECT_TITLE: NeuroMAP Phase II - Recruitment and Assessment Core


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Data Science;Health Services;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: TEMPE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Our proposed research is highly relevant to NIBIB mission to transform through engineering the  understanding of disease and its prevention, detection, diagnosis, and treatment. Our research goal is to  develop AI-enabled MUSE technology for at-home health monitoring of AKI patients through fusion of urine  biomarkers, ECG and EMR. Our research aligns perfectly with Goals 2 and 4 of NIBIB Strategic Vision by  making healthcare more accessible to all through development of point-of-care wireless and personal health  informatics technology. Our work will lead to new insights into health management of AKI patients.

PI_NAMEs: BANERJEE, IMON ;SANYAL, ARINDAM  (contact)

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: acute care;Acute Renal Failure with Renal Papillary Necrosis;Address;Adult;age stratification;Algorithms;analog;Arizona;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;Biological Assay;Biological Markers;Cardiovascular system;Caring;Cellular Phone;Clinic;Clinical;Clinical Trials;Clinics and Hospitals;cohort;Communication;comorbidity;computer scientist;Computer Vision Systems;Computerized Medical Record;Computers;Creatinine;Data;Data Set;deep learning;demographics;design;Detection;detection assay;detection platform;Development;Devices;Diagnosis;Disease;Early Diagnosis;Electrical Engineering;Electrocardiogram;encryption;Energy consumption;Engineering;Evaluation;Event;Fatigue;flexibility;follow-up;Future;Gender;Goals;Guidelines;Health;health management;Health Status;Healthcare;healthcare burden;high risk;Home;hospital readmission;Hospitals;Image;improved;Ink;innovation;insight;Institution;Lead;Learning;Medical;Medical Records;Microfluidics;Mission;mobile application;model design;Monitor;mortality;multimodal fusion;multimodality;National Institute of Biomedical Imaging and Bioengineering;next generation;non-invasive system;Observational Study;Participant;patient health information;Patient Monitoring;Patient-Focused Outcomes;Patients;personalized predictions;point of care;poor health outcome;Prevention;Printing;Process;Protocols documentation;Public Health Informatics;Reader;readmission rates;Records;Recurrence;Research;Risk;Risk Assessment;risk prediction;Running;Sampling;sensor;sensor technology;Signal Transduction;Skin;skin patch;smartphone application;Strategic vision;Survivors;System;Technical Expertise;Technology;Training;transmission process;Travel;Urea;urinary;Urine;Urologist;Visit;volunteer;wearable device;wireless;Work

PROJECT_TITLE: SCH: Artificial Intelligence enabled multi-modal sensor platform for at-home health monitoring of patients


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Mental Health;Neurosciences

PI_NAMEs: SAVITZ, JONATHAN  (contact)

PROJECT_TERMS: Acceleration;Affect;Anxiety Disorders;Applications Grants;approach behavior;Area;Arkansas;Astrocytes;Award;base;Behavior;Biological;Blood specimen;Brain;Businesses;Cities;Common Core;cost;cost estimate;Data;Data Analyses;Data Element;data management;Data Set;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Ensure;Environment;Equilibrium;extracellular vesicles;Extramural Activities;Fee-for-Service Plans;Formulation;Functional disorder;Functional Magnetic Resonance Imaging;Future;Geographic Locations;Goals;Grant;health assessment;Health Sciences;Hospitals;Human;Image;Immunology;Individual;Inflammation Mediators;Inflammatory;Infrastructure;Interoception;Laboratories;laboratory equipment;Laboratory Procedures;Link;Magnetic Resonance Imaging;Measurement;Measures;Mental Health;Metabolic Marker;Metabolism;MicroRNAs;Molecular;Molecular Biology;Mood Disorders;motivated behavior;Motivation;Myelin;National Institute of Mental Health;Negative Valence;neural circuit;neuroimaging;neuroinflammation;Neurons;Neurosciences;Oklahoma;Paper;Participant;Phase;Pilot Projects;Positive Valence;Process;Proteins;Publications;reconstruction;recruit;Research;Research Domain Criteria;Research Personnel;Research Project Grants;Research Support;Resources;response;Rest;Sampling;Services;Signal Transduction;statistics;Stimulus;Structure;success;System;Testing;Thinking;Time;Universities;Update;Validation;Work

PROJECT_TITLE: NeuroMAP Phase II - Circuits and Molecules Core


NIH_SPENDING_CATS: Clinical Research;Genetics;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases

PHR: PROJECT NARRATIVE While idiopathic pulmonary fibrosis (IPF) is an incurable, fatal disease of an unknown cause, recent studies have shown that the immune system may play a key role in causing this disease. I have previously shown that cells will release their mitochondrial DNA (mtDNA) in response to injury, and this mtDNA can lead to activation of the immune system. Through our cell, mouse, and human studies, I will investigate the ways in which mtDNA interacts with the immune system as one possible cause of IPF, which can lead to exciting new areas of drug development to combat this devastating disease.

PI_NAMEs: RYU, CHANGWAN  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acceleration;Actins;Activities of Daily Living;Adult;alveolar epithelium;antifibrotic treatment;Area;Biological Assay;Biomedical Engineering;Biometry;Bleomycin;Bronchoalveolar Lavage;career;career development;Career Mobility;cell injury;Cells;Cellular Assay;Chronic lung disease;Clinical;cohort;Collagen;combat;Computational Biology;cost;curative treatments;Dedications;Department chair;Deposition;Development;Disease;Dose;drug development;Endosomes;Environment;epithelial injury;Experimental Models;Exposure to;extracellular;Extracellular Matrix;Fellowship;Fibroblasts;Fibrosis;fibrotic lung;fibrotic lung disease;Funding;Genes;genomic profiling;Goals;Grant;Harvest;Human;idiopathic pulmonary fibrosis;immune activation;Immune system;Immunologic Receptors;In Vitro;in vitro Model;in vivo;Inflammation;Inflammatory;Inhalation;inhibitor;insight;Interstitial Lung Diseases;Laboratories;Longitudinal cohort;Lung;Lung Transplantation;Measurement;mechanotransduction;Mediating;Mentors;Mentorship;metabolic profile;Methods;Mitochondria;Mitochondrial DNA;Modeling;Molecular;mortality;Mus;Myofibroblast;Natural Immunity;Nature;novel;novel therapeutics;Outcome;overexpression;Pathogenesis;Patients;Pattern;Pharmaceutical Preparations;Phenocopy;Phenotype;Physicians;Plasma;Play;polyacrylamide hydrogels;Process;Pulmonary Fibrosis;Radiation;Reporter;Research;Research Personnel;Research Project Grants;response;response to injury;Role;Scientist;Secondary to;side effect;single-cell RNA sequencing;Smooth Muscle;Structure of parenchyma of lung;Testing;TGFB1 gene;Time;TLR9 gene;Toxic Environmental Substances;Training;Transforming Growth Factor-Beta Overexpression;translational medicine;translational study;Work

PROJECT_TITLE: Mitochondrial DNA and TLR9 in Pulmonary Fibrosis

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: THOMPSON, WESLEY KURT (contact)

PROJECT_TERMS: Accounting;Algorithms;Anxiety Disorders;Arkansas;base;Behavior;Behavioral Assay;Behavioral Paradigm;Biological Markers;biomarker identification;Brain imaging;Businesses;Categories;causal model;Cities;Common Data Element;Communities;Complex;computerized data processing;Consultations;Data;Data Collection;data management;data quality;Data Science;Data Scientist;data standards;data structure;design;Disease;Ensure;Environment;Experimental Designs;falls;Fee-for-Service Plans;follow-up;Future;Grant;health assessment;Health Sciences;Human Subject Research;Individual Differences;Infrastructure;Institution;Interoception;Leadership;machine learning algorithm;machine learning prediction;machine learning prediction algorithm;Measurement;Mental Health;Methods;Mood Disorders;multilevel analysis;Neurosciences;Oklahoma;operation;Outcome;Performance;Periodicals;Phase;Physiology;Pilot Projects;predict clinical outcome;Procedures;Process;programs;Protocols documentation;random forest;Randomized;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;Role;Sample Size;Sampling;Scheme;Services;Source;Statistical Data Interpretation;Statistical Methods;Statistical Models;statistics;Stimulus;study population;Symptoms;Target Populations;Thinking;Universities;Variant;Visualization;Weight;Work

PROJECT_TITLE: NeuroMAP Phase II - Data Management and Statistics Core


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Aging;Patient Safety

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE Reducing medication errors and improving medication safety are major national priorities. The objective of this conference grant is to host the Geriatric Medication Safety Symposium in the largest medical complex in the world, the Texas Medical Center, to disseminate and implement the evidence-based approaches for medication safety in older adults to improve the quality of geriatric care. This symposium will provide a unique interprofessional educational and research forum to make medication practices safer for older adults in the TMC and beyond.

PI_NAMEs: APARASU, RAJENDER R (contact);HOLMES, HOLLY M.

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Administrator;Adverse drug event;age related changes;Aging;Area;Beds;Body System;Caring;Chronic;Clinic;Collaborations;college;Complex;COVID-19 pandemic;Dental Schools;Development;Disease;Drug Interactions;Drug Prescriptions;Drug usage;Education;Educational Technology;Educational workshop;Elderly;Event;evidence base;experience;Funding;Goals;Grant;Harm Reduction;Health;Health Expenditures;Health Occupations;Health Professional;Healthcare;high risk;hospital readmission;Hospitalization;Hospitals;improved;Incidence;inpatient service;Institution;Joints;Journals;Knowledge;Lead;live stream;Medical;Medical Care Costs;Medical center;medical schools;Medication Errors;medication safety;meetings;member;Monitor;Morbidity - disease rate;mortality;Names;Nurses;Nursing Schools;off-label drug;older adult;Online Systems;opioid abuse;opioid use;outreach;Patient Care;patient safety;Patients;Peer Review;Persons;Pharmaceutical Preparations;Pharmacists;pharmacokinetics and pharmacodynamics;Pharmacy facility;Pharmacy Schools;Physicians;Policies;Polypharmacy;posters;Predisposition;Prevention;Process;Provider;Publications;Publishing;Research;Research Personnel;Risk;Scientist;Seasons;social;Students;symposium;Texas;tool;Treatment Failure;Universities;virtual;webinar

PROJECT_TITLE: Geriatric Medication Safety Symposium

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Rare Diseases;Rural Health;Social Determinants of Health

ORG_CITY: DES MOINES

ORG_NAME: IOWA ONCOLOGY RESEARCH ASSOCIATION

ORG_STATE: IA

PHR: Project Narrative The I-WORC NCORP has a proven track record as an efficient and disciplined team from six strategically located Iowa and Illinois communities. The coalition serves as the link between NCI-approved cancer research and over two million people in the state of Iowa and the eastern portion of Illinois with a history of achieving results in clinical cancer research while being a leader both locally and in nationwide cooperative groups. The I-WORC NCORP fosters quality in its research efforts and collaboration with local resources to promote clinical trial participation, bio-specimen collection, and cancer care delivery research.

PI_NAMEs: HARICHAND, SEEMA  (contact);SHEYBANI, ARSHIN

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Address;Administrator;Adolescent and Young Adult;American College of Radiology Imaging Network;anti-cancer research;Awareness;base;cancer care;Cancer Center;Cancer Control;cancer health disparity;Cancer Patient;cancer prevention;Cancer Trials Support Unit;care delivery;Caring;Catchment Area;Cities;Clinical;Clinical Research;clinical trial enrollment;Clinical Trials;clinically significant;Collaborations;Collection;Communities;Community Clinical Oncology Program;Community Hospitals;Community Outreach;County;Data;Discipline;disparity reduction;Eastern Cooperative Oncology Group;Elderly;Eligibility Determination;Enrollment;ethnic minority;experience;Family;Fostering;Geographic Locations;Goals;Gynecologic Oncology;Healthcare;Hospitals;human subject;Illinois;improved;Infrastructure;insight;Institution;Iowa;Link;Malignant Neoplasms;Medical;Medical center;Medical Oncology;meetings;member;multidisciplinary;news;Oncology;operation;patient population;Patients;Pediatric Hospitals;Pediatric Oncology;performance site;Persons;Physicians;precision medicine;Precision medicine trial;Prevention;Process;programs;protocol development;Protocols documentation;Provider;racial minority;Radiation Oncology;Recording of previous events;recruit;Research;Research Personnel;research study;Resources;rural area;screening;screening program;Sexual and Gender Minorities;Site;Surgical Oncology;Underserved Population;Work

PROJECT_TITLE: Iowa-Wide Oncology Research Coalition (I-WORC)


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Immunization;Immunotherapy;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the development of novel immune interception strat- egies in relevant animal models will accelerate the translation to humans and decrease cancer incidence among Lynch Syndrome patients. Thus, the proposed research is relevant to the mission of the NIH, particularly the portion pertaining to the pursuit of fundamental knowledge to extend healthy life.

PI_NAMEs: GRAY, STANTON BRADLEY;VILAR SANCHEZ, EDUARDO  (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Acceleration;Adaptive Immune System;Adjuvant;Adrenal Glands;Affect;Agonist;American;Animal Model;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;bioinformatics pipeline;Biological Assay;cancer cell;cancer prevention;cancer type;Cancer Vaccines;Catalogs;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell killing;Cell Line;Cells;Chemopreventive Agent;Clinical Chemoprevention;Clinical Trials;co-clinical trial;Coculture Techniques;Code;cohort;Collecting Cell;Colorectal;Colorectal Cancer;Combined Vaccines;Coupled;cytokine;cytotoxic;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;cytotoxicity;Development;DNA;Endometrium;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;familial colorectal cancer;first-in-human;Fostering;gene repair;Genes;Genomics;Germ-Line Mutation;Goals;Hereditary Nonpolyposis Colorectal Neoplasms;high risk;Human;Immune;immune activation;immune stimulant;Immune system;immunogenic;immunogenicity;Immunologic Monitoring;Immunologics;In Vitro;Incidence;Industry Collaboration;innovation;insertion/deletion mutation;Knowledge;Life;Macaca mulatta;Malignant Neoplasms;Mass Spectrum Analysis;MHC Class I Genes;Microsatellite Repeats;Mismatch Repair;Mismatch Repair Deficiency;Mission;MLH1 gene;Modeling;Mucous Membrane;Naproxen;neoantigen vaccine;neoantigens;next generation sequencing;Non-Steroidal Anti-Inflammatory Agents;nonhuman primate;Normal Cell;novel;Outcome;Ovary;Patients;Pattern;Penetration;Peptides;Peripheral Blood Mononuclear Cell;Permeability;Phase;Phenotype;Physiological;Population;Population Genetics;premalignant;Prevention;prevention clinical trial;Preventive vaccine;Public Health;Publishing;Recurrence;Reporting;Research;response;Rhesus;Safety;Small Intestines;Stomach;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Tissues;Toll-like receptors;tool;translation to humans;Translations;tumor;United States National Institutes of Health;Vaccination;vaccine development;vaccine platform;Vaccines;Validation

PROJECT_TITLE: Cancer Immune-Interception in a Spontaneous Non-Human Primate Model of Lynch Syndrome

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Lymphatic Research;Microbiome;Precision Medicine

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative This research will further our understanding of why certain cancer patients respond better than others to immunotherapy. By determining which features of our intestinal microbiome contribute to enhancing or mitigating response to therapy, it may become possible to design better immunotherapies. This could result in more frequent therapeutic responses among cancer patients and in more durable remissions.

PI_NAMEs: LITTMAN, DAN  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: adaptive immunity;Adverse effects;anti-PD-1;anti-PD1 therapy;anti-tumor immune response;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antibodies;Antigenic Specificity;antitumor effect;Autoimmune Diseases;autoimmune pathogenesis;autoimmune toxicity;Bacteria;Bacteroides;Biopsy;Cancer Model;Cancer Patient;Cannulations;cell killing;Cell Separation;Cell Wall;Cells;cellular targeting;checkpoint therapy;Chemosensitization;Clinical Research;cohort;commensal bacteria;commensal microbes;Communities;Consensus;CTLA4 gene;Cytotoxic T-Lymphocytes;design;Diet;Disease remission;Distal;Event;experience;fecal transplantation;Feces;Genes;Genetic Diseases;Genetic Engineering;Gnotobiotic;Growth;gut microbiome;gut microbiota;Histologic;Human;Immune;immune checkpoint blockade;Immune response;Immune system;Immune Targeting;immunogenic;immunogenicity;Immunotherapy;Implant;improved;in vitro testing;Individual;insight;Intestines;IRF3 gene;Lead;Libraries;Life;Lipid A;Lung Adenocarcinoma;lung cancer cell;Lung Neoplasms;Lymph;Lymphocyte;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;mesenteric lymph node;mesenteric lymphatics;metabolomics;Metagenomics;Microbe;microbial;microbial products;microbiome;microbiota;microbiota composition;microorganism antigen;Microscopic;Mismatch Repair;Modeling;Molecular Mimicry;Molecular Target;mouse model;Mus;Mutation;Myeloid Cells;neoantigens;neoplastic cell;Normal tissue morphology;Organism;Patients;Pattern recognition receptor;PD-1/PD-L1;Peptides;Plasma;Polysaccharides;Population;pre-clinical;Predisposition;programmed cell death ligand 1;Proteins;Proteomics;rational design;reconstitution;Relapse;Research;resident commensals;responders and non-responders;response;response biomarker;Role;Serum;Signal Pathway;Signal Transduction;Solid;Solid Neoplasm;Specimen;Stains;T-cell receptor repertoire;T-Lymphocyte;Testing;Therapeutic;Tissues;Toxic effect;transcriptome sequencing;transcriptomics;transmission process;Treatment Efficacy;treatment response;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Tissue;Wild Type Mouse;Work

PROJECT_TITLE: Mechanism of microbiota-mediated potentiation of checkpoint blockade efficacy in lung cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Microbiome;Pancreatic Cancer;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE Pancreatic cancer is a highly fatal malignancy. Our research is designed to identify oral fungi associated with risk for this disease, and to identify related fungal microbial–host tumor immune interrelationships in pancreatic tissue. The study will expand our current limited knowledge on the causes of pancreatic cancer, will help to identify people at high risk for this disease, and may lead to microbial-based prophylactic preventions for pancreatic cancer.

PI_NAMEs: AHN, JIYOUNG  (contact);HAYES, RICHARD BERNARD

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: 16S ribosomal RNA sequencing;adaptive immunity;Address;American Cancer Society;Animals;Bacteria;bacteriome;Biological Assay;Biomass;Cancer Burden;cancer prevention;Cancer Prevention Study II;cancer risk;Candidiasis;Clinical;clinical practice;cohort;Communities;Data;density;design;Development;Diagnosis;Dideoxy Chain Termination DNA Sequencing;Disease;disorder risk;Etiology;experimental study;Exposure to;Flow Cytometry;fungal microbiota;fungus;General Population;Genes;Genetic;Genetic Diseases;Goals;high risk;Human;Immune;Immune response;Immunity;Immunohistochemistry;improved;individualized prevention;Infiltration;innovation;Intervention;Investigation;Joints;Knowledge;Location;Lymphoid Cell;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolic;Microbe;microbial;microbial host;microbiome;microbiota;multidisciplinary;mycobiome;Myeloid Cells;Natural Immunity;Nature;Nested Case-Control Study;novel;Obesity;Oral;oral bacteria;Oral cavity;oral diagnostics;oral fungal;oral microbial community;oral microbiome;Outcome;Pancreas;pancreas development;Pancreatic Adenocarcinoma;Pancreatic Diseases;pancreatic neoplasm;pancreatic tumorigenesis;Pancreatitis;Patients;Persons;Phenotype;polymicrobial biofilm;prevent;Prevention;Preventive measure;Process;prophylactic;Prospective Studies;Reporting;Research;Research Design;Risk;Risk Factors;Sampling;Screening for cancer;Smoking;Testing;Tissues;tool;tumor;Tumor Immunity;Tumor Tissue;tumor-immune system interactions;Validation

PROJECT_TITLE: The Oral Mycobiome and Risk of Pancreatic Cancer


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Cancer;Cannabinoid Research;Chronic Pain;Complementary and Integrative Health;Endocannabinoid System Research;Neurosciences;Pain Research;Palliative Care;Rare Diseases;Therapeutic Cannabinoid Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Bone destruction from primary or metastatic cancer is associated with severe pain that is difficult to treat. Opioids are often used for cancer pain but are associated with many serious side effects, and non-opioid alternatives are needed. We will determine the effectiveness and mechanisms underlying antinociceptive properties of Resolvin D1 in a mouse model of bone cancer pain.

PI_NAMEs: KHASABOV, SERGEY G (contact)

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: Absence of pain sensation;addiction;Adverse effects;Affect;Anabolism;Analgesics;antinociception;Attenuated;Behavioral;Biochemical;Biophysics;bone;Bone neoplasms;Bone Pain;Brain;Brain Stem;Cancer Model;cancer pain;Cancer Pain Management;cancer therapy;cannabinoid receptor;carcinogenesis;Cells;Central Nervous System;Clinical;CNR1 gene;Data;Derivation procedure;Development;Disseminated Malignant Neoplasm;effectiveness evaluation;Electrophysiology (science);endocannabinoid signaling;Endocannabinoids;Enzyme Inhibition;evidence base;experience;Goals;Hydrolysis;Hyperalgesia;imaging approach;In Vitro;in vivo;Inflammatory;innovation;interdisciplinary approach;Knowledge;Life;lipid mediator;Malignant Bone Neoplasm;Malignant Neoplasms;Mediating;Membrane;Metastatic Neoplasm to the Bone;Molecular;motor impairment;mouse model;Nervous System;Neurons;Nociception;Nociceptors;non-opioid analgesic;novel;Omega-3 Fatty Acids;Opioid;Outcome;Pain;Pain management;Pathway interactions;Patients;Peripheral;Peripheral Nervous System;Polyunsaturated Fatty Acids;Posterior Horn Cells;preference;Property;Prostaglandin Inhibition;Prostaglandins;receptor;Research;response;Role;side effect;Spinal;Spinal Cord;success;Techniques;Testing;Therapeutic;Tissues;transmission process;treatment strategy;Ventilatory Depression

PROJECT_TITLE: Treatment of cancer pain by lipid mediator Resolvin D1: role of Prostaglandin and Endocannabinoid signaling


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness

PI_NAMEs: TSUCHIYAGAITO, AKI  (contact)

PROJECT_TERMS: Acute;Adult;Age;Anterior;anti-depressive agents;Area;arm;Attenuated;Back;Behavioral;Brain;Brain region;cognitive process;comorbidity;Data;depressive symptoms;Detection;Diagnostic;Disease;Double-Blind Method;effective therapy;efficacy study;emerging adult;Emotional;Episodic memory;Equipment and supply inventories;Event;experience;Feedback;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;health assessment;heuristics;indexing;Individual;Individual Differences;Informal Social Control;Insula of Reil;Language;language processing;Link;Major Depressive Disorder;Measurable;Measures;Mediating;Mental Depression;Mental disorders;Mental Health;Methods;Modality;Montgomery and Asberg depression rating scale;neural;neural circuit;neurobiological mechanism;neurofeedback;neuroregulation;Neurosciences;novel;Outcome;Participant;Patients;Pharmaceutical Preparations;placebo group;Play;primary outcome;Process;Prognosis;Psychotherapy;Randomized;Recovery;Recurrence;Regulation;Research Domain Criteria;Residual state;response;Role;rumination;Running;secondary analysis;secondary outcome;Severities;Signal Transduction;Speech;Structure of superior temporal sulcus;suicidal;Suicide;Symptoms;theories;therapy design;therapy resistant;Thinking;Time;tool;Training;trait;Translating;Unemployment;United States National Institutes of Health;Visit;Work;young adult

PROJECT_TITLE: Project 3: Modulating repetitive negative thinking related brain networks in young adults with depression