ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE  Despite the promise of adeno-associated virus (AAV)-mediated delivery of anti-HIV biologics for preventing and treating HIV infection, translating this approach to the clinic is hindered by the high prevalence of anti-AAV neutralizing (n) antibodies (Abs) in humans. To tackle this barrier, we will identify the least prevalent AAV serotypes in people living with HIV in the epicenter of the HIV/AIDS epidemic and assess whether depletion of circulating IgG molecules can reduce pre-existing anti-AAV Ab levels sufficiently to allow AAV-mediated delivery of anti-HIV biologics to nonhuman primates. If successful, this research could bring us closer to testing the efficacy of AAV-based immunotherapies in people, regardless of their AAV serostatus.

PI_NAMEs: MARTINS, MAURICIO DE AGUIAR (contact)

PROGRAM_OFFICER_NAME: ZHOU, YAN

PROJECT_TERMS: Address;adeno-associated viral vector;adenovirus mediated delivery;Africa South of the Sahara;AIDS clinical trial group;Animals;Antibodies;antiretroviral therapy;Area;Benchmarking;Biological Products;Bypass;Capsid;Cells;Circulation;Clinic;Clinical;Clinical Research;Clinical Trials;clinically relevant;combat;Country;Cross Reactions;cross reactivity;Dependovirus;Developed Countries;Dose;efficacy testing;Endopeptidases;Epidemic;Epidemiology;Excision;Exclusion;experimental study;Fc Receptor;gene product;gene therapy;Genes;Genome;Geography;Goals;High Prevalence;HIV;HIV Infections;HIV Vaccine Trials Network;HIV/AIDS;Home;Human;Humoral Immunities;Immunity;Immunoglobulin G;Immunotherapy;improved;in vivo;Individual;Infection;Infusion procedures;inhibitor;Injections;Interruption;Intervention;Intramuscular;Knowledge;Macaca;Macaca mulatta;Mediating;mindfulness;Monitor;Monkeys;Monoclonal Antibodies;Monoclonal Antibody Therapy;Muscle;Muscle Cells;neonatal Fc receptor;nonhuman primate;pandemic disease;Persons;pharmacologic;Plasmapheresis;preclinical study;Prevalence;prevent;Primates;Production;Research;Resistance;Role;Series;seropositive;Seroprevalences;serosurvey;Serotyping;Serum;SIV;success;Testing;Time;transgene expression;Transgenes;Translating;vector;Virus Diseases;Virus Replication;Vision

PROJECT_TITLE: Overcoming pre-existing immunity to AAV to enhance AAV-based HIV immunotherapies

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: DE

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Dental, Oral, and Craniofacial Disease

ORG_CITY: MINNEAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: DENTISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Mentoring and supporting underrepresented individuals is essential to developing a diverse pool of researchers for the next generation. The Minnesota Craniofacial and Oral health Research Experience (MnCORE) focuses on exposing undergraduates to dental, craniofacial, and oral biology research through an immersive summer research experience.

PI_NAMEs: MANSKY, KIM CARPENTER (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Academic achievement;Accreditation;Admission activity;Advisory Committees;Affect;Biocompatible Materials;Biological Sciences;Biology;bone;career;Career Choice;career development;cohort;community college;Complement;craniofacial;Credentialing;Dental;Dental Research;Dental Schools;Development;Disease;Doctor of Philosophy;education research;effectiveness evaluation;Elements;Ensure;Environment;Evaluation;experience;Faculty;Feedback;Foundational Skills;Foundations;Funding;Future Generations;Goals;graduate school;Immunology;improved;Individual;Institution;interdisciplinary approach;interest;Laboratories;Learning;Letters;Malignant Neoplasms;Mathematics;Measures;meetings;member;Mentors;Mentorship;Microbiology;Minnesota;Mission;Mouth Diseases;National Institute of Dental and Craniofacial Research;next generation;Oral;oral biology;Oral health;Participant;Persons;Population;Program Development;programs;Qualifying;Recommendation;recruit;Recruitment Activity;Reporting;Research;research and development;research faculty;Research Personnel;Research Project Grants;Research Training;Resources;School Dentistry;Science;skills;Social support;strength training;Student recruitment;Students;success;summer research;Surgeon;Surveys;Talents;Texas;Training;Training Programs;Treatment Cost;undergraduate research experience;undergraduate student;United States;Universities;Work

PROJECT_TITLE: Minnesota Craniofacial and Oral Health Research Experience


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orthopoxviruses;Rare Diseases

ORG_CITY: LINCOLN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: Viral manipulation of signal transduction is a fundamental determinant of the outcome of many infections, and is therefore of broad biomedical importance. The studies in this application will result in a greater understanding of pathways governing both mitosis and antiviral responses to extrachromosomal DNA. The insights gained will allow for future development of diagnostic tools and therapies targeting infectious diseases.

PI_NAMEs: WIEBE, MATTHEW S (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Address;Affinity;Anti-viral Response;Binding;Biology;Cell division;Cell Nucleus;Cells;cellular targeting;Communicable Diseases;Comparative Study;Complex;Cultured Cells;Cytoplasm;Data;diagnostic development;diagnostic tool;DNA;DNA biosynthesis;DNA Damage;ds-DNA;Enzymes;Eukaryota;Exhibits;extrachromosomal DNA;Family;fascinate;Future;Gene Expression;Genetic Transcription;Genome;Goals;Histones;Homologous Gene;Host Defense;Human;Immunity;In Vitro;Infection;innovation;insight;Investigation;Knowledge;Laboratory Study;Life Cycle Stages;loss of function;Masks;Mediating;member;Mitosis;Mitotic;Modification;Molecular;Mutation Analysis;Names;novel;Nuclear;Outcome;Pathway interactions;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physical condensation;Play;Post-Translational Protein Processing;Poxviridae;Poxviridae Infections;Process;Property;Protein Family;Protein Kinase;Protein phosphatase;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;Regulation;Repression;Research;response;Set protein;Signal Transduction;Structure;targeted treatment;Testing;transcription factor;Vaccinia;Viral;viral DNA;Viral Genome;Virus;virus host interaction;Work

PROJECT_TITLE: Subversion of Cellular Mitotic and Antiviral Signaling by Poxviral Kinases

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Mental Illness;Neurosciences

ORG_CITY: COLUMBIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative Repetitive behaviors are commonly observed in numerous disorders such as obsessive-compulsive disorder, Tourette’s syndrome, and autism spectrum disorders and there is a critical need to identify better treatment strategies to help patients with these disabling symptoms. In recent years, highly selective positive allosteric modulators (PAMs) for M4 muscarinic receptors have emerged as exciting new therapeutic agents that can modulate striatal circuitry in the brain that is heavily implicated in regulating repetitive behaviors in both animal models and human patients. We propose a series of studies aimed at elucidating the utility of M4 PAMs as novel therapeutics to treat these symptoms and test the hypothesis that M4 PAMs can reduce repetitive behaviors in preclinical animal models by normalizing striatal neurotransmission.

PI_NAMEs: FOSTER, DANIEL J (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Animal Model;Antipsychotic Agents;autism spectrum disorder;Basal Ganglia;Behavior;Behavior Therapy;Behavioral;behavioral study;Brain;Brain region;Cell Physiology;Clinical;Clinical Data;CNR2 gene;Corpus striatum structure;Data;disabling symptom;Disease;Dopamine;Electric Stimulation;Electrophysiology (science);endocannabinoid signaling;Environment;experimental study;Gene Modified;Genetic;genetic approach;Gilles de la Tourette syndrome;glutamatergic signaling;Glutamates;Goals;Grooming;Human;Hyperactivity;Impairment;in vivo;Induced Neurons;innovation;Knockout Mice;Learning;Long-Term Depression;Mediating;Mental disorders;mouse model;Mus;Muscarinic Acetylcholine Receptor;Mutant Strains Mice;Nervous System Disorder;Neurons;neurotransmission;novel;novel strategies;novel therapeutics;Obsessive-Compulsive Disorder;optogenetics;Pathologic;Patients;Periodicity;pharmacologic;Phenotype;Physiological;Physiology;Play;positive allosteric modulator;pre-clinical;presynaptic;receptor;Receptor Activation;reduce symptoms;Refractory;Regulation;repetitive behavior;Resistance;Role;Scanning;Selective Serotonin Reuptake Inhibitor;Series;Signal Transduction;Social Interaction;Structure;symptom treatment;Synapses;Testing;Therapeutic;Therapeutic Agents;tool;transmission process;treatment strategy;Wild Type Mouse

PROJECT_TITLE: Pharmacological modulation of striatal physiology and repetitive behaviors by M4 PAMs

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BOSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: This proposal will investigate a specific type of RNA modification, termed methylation. We will study how RNA methylation changes in Alzheimer’s disease, and whether reducing excessive methylation can delay disease progression and help patients with the disease.

PI_NAMEs: WOLOZIN, BENJAMIN L (contact);ZHANG, XIAOLING

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: abeta accumulation;Acceleration;Adaptor Signaling Protein;Adenosine;Affect;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyotrophic Lateral Sclerosis;Area;biological adaptation to stress;Biological Markers;Biology;Cellular biology;Code;Complex;Data;Disease;Disease Progression;Elements;epitranscriptomics;Exhibits;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;gene therapy;Genetic Polymorphism;genotoxicity;Human;Image;induced pluripotent stem cell;Inflammation;innovation;Label;Laboratories;lens;Link;Measures;Mediating;member;Methylation;Methyltransferase;Modeling;Modification;Molecular;mouse model;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neuropathology;novel diagnostics;novel therapeutic intervention;novel therapeutics;Oncology;Pathologic;Pathology;Pathway interactions;Patients;Proteins;Proteome;Reader;Research;response;Risk Factors;risk variant;RNA;RNA Degradation;RNA metabolism;RNA methylation;RNA Splicing;RNA-Binding Proteins;Role;Severity of illness;Site;Stress;stress granule;Synapses;tau aggregation;tau function;tau Proteins;Tauopathies;therapeutic target;tool;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Untranslated RNA;Vascular Diseases

PROJECT_TITLE: The role of N6-methyladenosine modified RNA in Alzheimer's disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Microscopic colitis, a relapsing inflammatory disease of the large intestine caused by a dysregulated immune response to changes in the gut luminal microenvironment, affects approximately 1 in 115 females and 1 in 286 males over a lifetime but has no FDA-approved therapies. Diet is the largest contributor to the gut luminal microenvironment but remains unexplored in microscopic colitis; as such, this proposal comprehensively examines the role of dietary patterns and downstream plasma and gut-microbiome-derived metabolites in disease pathogenesis and treatment outcomes. This proposal represents a critical step to advancing our understanding of microscopic colitis pathogenesis, with the goal of ultimately advancing treatment strategies for this debilitating disease.

PI_NAMEs: BURKE, KRISTIN E. (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Adherence;Affect;Age;Algorithms;Anti-Inflammatory Agents;Area;Award;Biological;Blood specimen;Butyrates;career;career development;Cell membrane;Characteristics;chronic inflammatory disease;Clinical;cohort;Colitis;Colonic inflammation;Colorectal Cancer;Consumption;Cues;cytokine;Data;Development;Diagnostic;Diet;Diet therapy;dietary;Dietary Factors;Dietary Fiber;Dietary Practices;Disease;Disease Outcome;Environment;Environmental Risk Factor;Epidemiology;Faculty;FDA approved;Female;Fishes;Follow-Up Studies;Food;Fruit;fruits and vegetables;Functional disorder;Future;Gastroenterologist;gastrointestinal epithelium;General Hospitals;Genetic;Goals;gut inflammation;gut microbiome;Health Professional;immune activation;Immune response;Immune Tolerance;Immunity;Impairment;Incidence;Individual;Inflammatory;Inflammatory Bowel Diseases;inflammatory marker;insight;Intake;interest;Intestines;intraepithelial;Large Intestine;Link;Longitudinal cohort;Lymphocyte;lymphocyte trafficking;Maintenance;male;Massachusetts;Measures;Meat;Mediating;Mediterranean Diet;Mentors;Mentorship;Metabolic;metabolic abnormality assessment;Metabolic Pathway;metabolic profile;metabolomics;microbiome;microbiome composition;Microscopic Colitis;Modeling;Nested Case-Control Study;novel;Nurses' Health Study;nutritional epidemiology;older adult;Outcome;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Physicians;Plasma;Play;population based;Prediction of Response to Therapy;Prevention strategy;Preventive treatment;Process;Processed Meats;Production;prospective;Prospective cohort;Public Health Schools;Quality of life;Recommendation;Relapse;Research;Research Personnel;Risk;Role;sex;Shapes;Sphingolipids;T-Lymphocyte;Testing;therapeutic target;Training;Treatment outcome;treatment response;treatment strategy;Tryptophan;Tryptophan Metabolism Pathway;United States National Institutes of Health;Vegetables;Volatile Fatty Acids;Work

PROJECT_TITLE: Diet and metabolic factors in the pathogenesis of microscopic colitis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative This project will characterize protective antibody responses against the major virulence factors of Clostridium difficile and define the binding regions of these protective antibodies. Such studies will lead to the discovery of antibody biomarkers that predict disease outcomes and help to design novel vaccines against the infection.

PI_NAMEs: FENG, HANPING  (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: anti-toxin;Antibodies;Antibody Response;B-Lymphocytes;Binding;Biological Markers;Cells;Characteristics;Clinical;Clostridium difficile;Data;design;Development;Diagnosis;Disease;Disease Outbreaks;Disease Outcome;Disease Progression;Enzyme-Linked Immunosorbent Assay;Epitopes;Financial cost;Frequencies;Future;Goals;gut inflammation;Human;Immune;Immune response;Immunity;Immunodominant Epitopes;Immunoglobulin A;Immunoglobulin G;Immunoglobulin Isotypes;Individual;individual patient;Infection;infection management;intestinal injury;Kinetics;Knowledge;Maps;Mediating;method development;Monoclonal Antibodies;Morbidity - disease rate;mortality;neutralizing antibody;novel;novel vaccines;Outcome;outcome prediction;Passive Immunotherapy;Patients;predictive marker;predictive test;Prevention;Property;Recurrence;response;Serum;Severities;Severity of illness;Specificity;Testing;Therapeutic;tool;Toxin;Vaccines;Virulence Factors

PROJECT_TITLE: Characterization of neutralizing antitoxins and epitopes in Clostridium difficile patients

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Epilepsy of infancy with migrating focal seizures (EIMFS) is a condition associated with very severe intellectual disability. It is caused by mutations in the KCNT1 gene, which encodes the Slack potassium channel, a protein that regulates both firing patterns and the translation of new mRNAs in neurons. The experiments in this proposal will determine how such mutations alter the excitability of excitatory and inhibitory neurons in the cerebral cortex and how they control the synthesis of other types of channels, information critical to the development of new therapeutic approaches.

PI_NAMEs: KACZMAREK, LEONARD K (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: 3' Untranslated Regions;Action Potentials;Animal Model;Animals;Antisense Oligonucleotides;autism spectrum disorder;beta Actin;Binding;Biological Assay;C-terminal;cell cortex;cell growth regulation;Cell Line;Cell membrane;cell type;Cerebral cortex;Characteristics;childhood epilepsy;Coupled;Cytoplasm;Development;differential expression;disease-causing mutation;early onset;Electrophysiology (science);Ensure;Epilepsy;excitatory neuron;experimental study;FMR1 gene;Focal Seizure;gain of function;gain of function mutation;Genes;Glutamates;Goals;hippocampal pyramidal neuron;Immunoprecipitation;In Situ Hybridization;infancy;inhibitor;inhibitory neuron;Interneurons;Ion Channel;Ions;Ligation;Location;Messenger RNA;migration;mouse model;mRNA Translation;Mus;mutant;Mutant Strains Mice;Mutation;neuronal excitability;Neurons;novel therapeutic intervention;Pattern;Peptides;Physiological;Potassium Channel;Process;Property;Protein Biosynthesis;Protein Isoforms;Proteins;Reporter;response;RNA;RNA Splicing;SCN1A protein;SCN2A protein;SCN8A gene;Seizures;severe intellectual disability;Signaling Protein;Sodium;Syndrome;Testing;Therapeutic;Time;Translations;Up-Regulation;voltage

PROJECT_TITLE: Cellular Regulation of Sodium-activated Potassium Channels

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Multiple Sclerosis is a devastating demyelinating disease that effects millions of Americans with limited therapeutic success. Our lab has identified inhibitors of select enzymes in the cholesterol biosynthesis pathway to be novel targets to inhibit to promote re-myelination. This proposal seeks to investigate this pathway further to identify other potential targets within the cholesterol biosynthesis pathway and the overall mechanism of these sterols to provide novel therapeutic angles.

PI_NAMEs: ATALA PLESHINGER, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Acceleration;Address;Adult;American;Automobile Driving;Axon;Biological Assay;Brain;candidate identification;Cell Count;Chemical Structure;cholesterol biosynthesis;Complex;Data;demethylation;Demyelinating Diseases;Development;Disease;drug discovery;Enzyme Inhibition;Enzymes;experimental study;Foundations;Genetic;Head;high throughput screening;improved;In Vitro;in vivo;Inferior;inhibitor;Lead;Multienzyme Complexes;Multiple Sclerosis;multiple sclerosis patient;Myelin;Myelin Sheath;myelination;Nature;Neuroglia;neurotransmission;new therapeutic target;novel;novel therapeutics;oligodendrocyte progenitor;Oligodendroglia;Oxidoreductase;Pathway interactions;Proteomics;Publishing;reduce symptoms;remyelination;repaired;Reporting;Research;Role;Signal Pathway;Signal Transduction;small molecule;stem cell differentiation;stem cell population;stem cells;Sterols;success;Tail;Therapeutic;therapeutic development;therapeutic target;tool;transcriptomics;Work

PROJECT_TITLE: Identifying novel targets and mechanistic role of 8,9 unsaturated sterol accumulation on enhancement of oligodendrocyte formation


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Diabetes;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

ORG_STATE: PA

PHR: Polypropylene slings/meshes are commonly used in the surgical treatment of women with urinary incontinence and/or pelvic organ prolapse. However, women with diabetes experience ~5-fold increase of mesh- related complications than the general population. The overall goal of this proposal is to determine whether hyperglycemic memory in innate immune cells negatively impact the long-term mesh outcomes despite peri- operative glycemic control, findings from which will guide future preventive strategies to improve the health care of women with diabetes receiving prosthesis-aided surgeries.

PI_NAMEs: LIANG, RUI  (contact)

PROGRAM_OFFICER_NAME: DEYAMPERT, TARA LYNN

PROJECT_TERMS: Adult women;Adverse effects;Affect;Age;Attenuated;biobank;bisulfite sequencing;Bone Marrow;Bone Marrow Cells;Bone Marrow Transplantation;Cells;chromatin immunoprecipitation;chronic pelvic pain;cytokine;Cytometry;Data;Development;Diabetes Mellitus;diabetic;diabetic rat;Enzymes;Epigenetic Process;Excision;experience;experimental study;fasting glucose;Foreign Bodies;Functional disorder;Future;General Population;Glucose;glycemic control;Glycosylated hemoglobin A;Goals;healing;Health;Health Care Costs;Healthcare;high risk;Human;Hyperglycemia;Immune;Immune response;Immunofluorescence Immunologic;Impaired healing;Impairment;Implant;implantation;improved;In Vitro;in vivo;Incidence;Infection;Inflammation;Inflammatory;inhibitor;Innate Immune Response;insight;Insulin;Investigation;Macrophage;Memory;Modeling;Modification;novel;Nuclear;Operative Surgical Procedures;Organ;Osmosis;Outcome;Patient Care;Patients;Pelvic Floor Disorders;pelvic organ prolapse;Perioperative;Phenotype;Polypropylenes;Population;prevent;Prevention strategy;Procedures;Property;Prosthesis;Pump;Quality of life;Rattus;Regimen;repaired;response;Risk;Risk Factors;Role;Signal Transduction;single-cell RNA sequencing;Site;standard of care;stem cells;Streptozocin;Stress Urinary Incontinence;subcutaneous;surgery outcome;Surgical wound;Technology;Testing;Time;Tissue Sample;Tissues;Transplantation;Urinary Incontinence;Vagina;Woman;women's outcomes;women's treatment

PROJECT_TITLE: Impact of hyperglycemic memory on innate immune response to urogynecologic mesh

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Infectious Diseases;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: Project Narrative The proposed research is relevant to public health because defining pathogenic mechanisms of bacteria that cause infective endocarditis is ultimately expected to lead to the development of more effective prognostic, diagnostic, preventative or therapeutic measures. Hence, the proposed research is relevant to the part of the NIH’s mission which pertains to gaining fundamental knowledge that will enhance health and reduce illness.

PI_NAMEs: KING, SAMANTHA JANE (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: 3-Dimensional;Address;Adhesions;Affinity;Aging;Avidity;Bacteria;Bacterial Adhesins;Bacterial Adhesion;Binding;Binding Proteins;Blood Platelets;Carbohydrates;Cells;Congestive Heart Failure;Data;defined contribution;Development;Diagnostic;Endocardium;experimental study;Family;Future;Health;Hospitalization;Human;Immunoglobulins;In Vitro;Infection;Infective endocarditis;inhibitor;innovation;Intervention;Knowledge;Lectin;Measures;Mediating;member;Microscopy;Mission;Modeling;Modification;Monitor;Morbidity - disease rate;mortality;Mutagenesis;mutant;Mutation;N-terminal;novel;Orthologous Gene;Parents;pathogen;Pathogenesis;Pathogenicity;Physiological;polypeptide;Polysaccharides;Population;prognostic;Protein Family;Protein Region;Proteins;Public Health;receptor;Recombinant Proteins;Recombinants;Reporting;Research;Role;Serine;sialic acid binding Ig-like lectin;Sialic Acids;sialylation;Specificity;Sterility;Streptococcus;Streptococcus mitis;Streptococcus oralis;Streptococcus Viridans Group;Structure;Surface;System;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;three-dimensional modeling;Time;United States National Institutes of Health

PROJECT_TITLE: Defining a novel mechanism of adhesion present in multiple infective endocarditis causing species

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-Y(80)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE Cardiovascular disease is the leading cause of morbidity and mortality, characterized by persistent inflammation following cardiac injury leading to dysfunctional remodeling. This project aims to understand the role of newly discovered non-coding RNA known as circular RNAs in the regulation of monocyte/macrophage biology in cardiac injury and repair. Findings from this proposed study may potentially be crucial in understanding new mechanisms of inflammation-regulated circular RNAs as new therapeutic targets for cardiac repair and remodeling.

PI_NAMEs: GONZALEZ, CAROLINA  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Accounting;Acute;adeno-associated virus 9 delivery;Affect;Anti-Inflammatory Agents;Antiinflammatory Effect;Apoptosis;Biogenesis;Biology;Blood;Bone Marrow;Cardiac;cardiac repair;Cardiovascular Diseases;Cause of Death;Cd68;Cell Physiology;Cerebellar Degeneration Related 1 Antisense;Cessation of life;Characteristics;chemokine;circular RNA;Code;cytokine;Data;Dependovirus;differential expression;efficacy evaluation;efficacy testing;Enzyme-Linked Immunosorbent Assay;Exhibits;Exposure to;Flow Cytometry;gain of function;Gene Expression;Genes;Genetic Transcription;Goals;Growth Factor;healing;Heart;Heart failure;heart function;Heart Injuries;Immunity;Immunoglobulin Class Switching;improved;In Vitro;in vivo;Infarction;Inflammation;Inflammatory;Inflammatory Response;injured;interest;Label;Learning;Left Ventricular Function;locked nucleic acid;loss of function;Macrophage;Macrophage Activation;Maintenance;Mediating;MicroRNAs;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;Mus;Myocardial Degeneration;Myocardial dysfunction;Myocardial Infarction;Myocardial Ischemia;Myocarditis;Myocardium;neovascularization;new therapeutic target;overexpression;Phenotype;Physiological;Population;Porifera;prediction algorithm;Process;Production;Proteins;Publishing;recruit;Regulation;repaired;Reporting;Resolution;response;RNA;RNA-Binding Proteins;Role;Sorting;Testing;Therapeutic;tissue repair;Tissues;Toxicology;Translations;United States;Untranslated RNA;Western Blotting

PROJECT_TITLE: The Role of circ-Cdr1as in monocyte/macrophage mediated cardiac injury and repair.


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Dementia;Health Services;Networking and Information Technology R&D (NITRD);Neurodegenerative;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because elderly patients with mild cognitive impairment and early-stage dementia are frequently underdiagnosed, posing significant burden on patients, families, and healthcare systems. Development of a novel screening algorithm built on easily accessible data generated in routine patient-clinician encounters has a strong potential to identify these patients, promoting timely care and preventing negative outcomes, particularly emergency department visits and hospitalizations. The proposed study is aligned with one of the National Institute of Aging’s Strategic Directions for Research (2020-2025), “Develop improved approaches for the early detection and diagnosis of disabling illnesses and age-related debilitating conditions.”

PI_NAMEs: ZOLNOORI, MARYAM  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Accident and Emergency department;Address;Affect;Age;age related;Algorithms;Asthma;Attention;Biological Markers;Biometry;care costs;Care given by nurses;career development;Caring;Cerebrospinal Fluid;Clinical;clinical care;Clinical Data;clinical encounter;Cognitive;cognitive function;Communication;Competence;cost;daily functioning;Data;Data Science;Data Set;data streams;Dedications;Dementia;Development;Diagnosis;Disabling;early detection biomarkers;Early Diagnosis;Early identification;Electronic Health Record;electronic health record system;Emergency department visit;Evaluation;executive function;Family;Goals;health care service;health care service utilization;health care settings;health record;Healthcare;Healthcare Systems;Home Care Services;Hospitalization;Impaired cognition;improved;Informatics;innovation;Intervention;Language;language impairment;Life Style;Medical Care Team;Memory impairment;Mentorship;Methods;mild cognitive impairment;Modeling;Motor;motor disorder;National Institute on Aging;Natural Language Processing;New York;novel;Nurses;Nursing Services;older adult;older patient;Outcome;Patient Admission;Patient Care;Patients;Performance;Pharmaceutical Preparations;Phase;Phonetics;Pilot Projects;Postdoctoral Fellow;pre-doctoral;prevent;programs;Property;provider communication;Public Health;Quality of life;Recording of previous events;Research;Research Personnel;Research Priority;Resources;Risk;Risk Factors;Risk Reduction;Scientist;screening;Screening procedure;Semantics;Services;showing emotion;skills;Speech;Structure;Symptoms;System;Systems Analysis;Techniques;Testing;Text;theories;Time;Training;Universities;verbal;Visiting Nurse;Work

PROJECT_TITLE: Development of a Screening Algorithm for Timely Identification of Patients with Mild Cognitive Impairment and Early Dementia in Home Healthcare

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Dietary Supplements;Neurosciences;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE Deuterium metabolic imaging (DMI) is a novel 3D method that can noninvasively map metabolism of non- radioactive, deuterium-labeled substrates in healthy or diseased brain. Choline is an essential nutrient that is often taken up and metabolized at a higher level in tumors than in normal tissue. Deuterium-labeled choline is a promising imaging probe that can be combined with DMI to map choline uptake and metabolism in brain tumors in vivo, and inform on tumor aggressiveness and treatment response.

PI_NAMEs: DE FEYTER, HENK  (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: 3-Dimensional;Anatomy;Animal Model;Animals;Brain;Brain Diseases;Brain imaging;Brain Mapping;Brain Neoplasms;brain size;brain tissue;brain tumor imaging;cancer type;Cell membrane;Cell Proliferation;Cells;chemotherapeutic agent;Choline;Clinic;Clinical;Clinical Research;clinical translation;contrast imaging;Data;Deoxyglucose;Detection;detection sensitivity;Deuterium;Development;dietary supplements;Disease Management;Disease Progression;Dose;early detection biomarkers;Evaluation;experimental study;Future;Glioblastoma;Glioma;glucose analog;glucose metabolism;glucose uptake;Goals;Growth;Human;Hydrogen;imaging detection;Imaging Device;imaging modality;imaging probe;Imaging Techniques;improved;in vivo;insight;Label;Lesion;Longitudinal Studies;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Measures;Medical Imaging;membrane synthesis;Metabolic;metabolic abnormality assessment;metabolic imaging;Metabolism;Methods;Modeling;mouse model;MRI Scans;Mus;Normal tissue morphology;novel;Nutrient;Oligodendroglioma-Astrocytoma;Patients;Phospholipids;Positioning Attribute;Positron-Emission Tomography;Primary Brain Neoplasms;Prognosis;Proliferating;Radioactive;Research Project Grants;Resolution;response;Rodent Model;Scanning;Signal Transduction;Solid;Specificity;stable isotope;standard of care;Techniques;temozolomide;Testing;Therapeutic;Tissues;Tracer;Translating;Translations;treatment effect;treatment response;tumor;tumor growth;tumor metabolism;tumor specificity;Tumor Tissue;Tumor Volume;uptake

PROJECT_TITLE: Mapping of choline uptake and metabolism in brain tumors with deuterium metabolic imaging (DMI)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Caregiving Research;Clinical Research;Mental Health;Social Determinants of Health

ORG_CITY: MADISON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Caregiving for an aging parent is often stressful and can impact caregivers’ health. We examine if this is particularly true for adult caregivers with histories of Adverse Childhood Experiences (ACEs). Investigating the experience of filial caregivers using the life course perspective can offer unique solutions to relieve caregivers’ stress and burden, ultimately promoting their health and well-being.

PI_NAMEs: KONG, JOOYOUNG  (contact)

PROGRAM_OFFICER_NAME: HOROWITZ, TODD S

PROJECT_TERMS: Address;Adult;Adult Children;adverse childhood events;Affect;Age;Aging;American;Applications Grants;Area;Attention;care giving burden;care recipients;career;career development;caregiver interventions;caregiver stress;Caregivers;caregiving;caregiving outcomes;Caring;Characteristics;Child;childhood adversity;coping;Coping Skills;Data;Data Analyses;Data Collection;Development Plans;diaries;Distal;early life adversity;Emotional;Emotions;Event;experience;Exposure to;Family;Family Caregiver;family caregiving;Family member;Family Relationship;Goals;Health;Household;Hydrocortisone;improved;innovation;Instruction;Interview;Knowledge;late life;Life;Life Cycle Stages;Link;Literature;Lived experience;Long-Term Effects;meetings;member;Mentored Research Scientist Development Award;Mentorship;Methodology;middle age;neglect;novel;Outcome;Parents;pediatric trauma;Personal Satisfaction;Persons;Physiological;Policies;Predisposition;Prevalence;programs;protective factors;psychobiology;Public Health;Qualitative Research;Recording of previous events;Reporting;Research;Research Methodology;Resources;response;Risk Factors;Role;skills;Social status;Societies;sociodemographics;Source;Specific qualifier value;statistics;Stress;Stress and Coping;Stressful Event;stressor;Substance Use Disorder;Surveys;Training;traumatic event;United States

PROJECT_TITLE: The Life Course Approach to Caregiving for Aging Parents: Role of Adverse Childhood Experiences

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative Molecular mechanisms that contribute to maintenance and modulation of body temperature under normal and adaptive conditions remain to be fully elucidated. The objective of this proposal is to use hibernation as a naturalistic model to understand basic mechanisms that underlie reversible hypothermia in mammals. Insights gleaned from these studies will facilitate the development of pharmacological agents for hypothermia induction.

PI_NAMEs: GRACHEVA, ELENA  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TITLE: Molecular and cellular basis of reversible hypothermia

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: HADLEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative Chronic distress has long been linked with increased risk of multiple chronic age-related diseases, including cardiovascular disease, diabetes and Alzheimer’s Disease and related dementias. Systematically dysregulated metabolic processes may be one mechanism linking high distress levels to later life poor health. Direct evidence that altered patterns of blood metabolites commonly occur in response to chronic distress in diverse populations will provide valuable information on biological pathways that explain how chronic distress leads to poorer cardiometabolic and cognitive health as people age, and may suggest novel targets for more effective intervention.

PI_NAMEs: HANKINSON, SUSAN E (contact);KUBZANSKY, LAURA D

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: Address;Affect;African American;Age;age related chronic disease;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Anxiety;Asian Americans;Automobile Driving;Biochemical;Bioinformatics;Biological;Biometry;Blood;Blood Vessels;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;Cause of Death;Chronic;Chronic stress;Cognitive;cohort;Cohort Studies;Data;data resource;dementia risk;Development;Diabetes Mellitus;disorder risk;Distress;effective intervention;Ethnic Population;Evaluation;follow-up;Funding;Genetic;Health;healthy aging;high risk;high throughput technology;Hispanic;Hispanic Populations;improved;Individual;insight;Intervention;Jackson Heart Study;large datasets;late life;Link;Liquid Chromatography;Measurement;Measures;Mediating;Mediator;men;Mendelian randomization;Mental Depression;Mental disorders;Metabolic;Metabolic Pathway;metabolic profile;Metabolism;metabolomics;Methods;Molecular;Multi-Ethnic Study of Atherosclerosis;Not Hispanic or Latino;novel;Nurses' Health Study;older adult;Outcome;Pathway interactions;Pattern;Persons;Phenotype;Plasma;Population;Population Heterogeneity;Population Study;Premature aging syndrome;Prospective Studies;racial disparity;racial population;racism;response;Risk;risk prediction;Sampling;Signal Transduction;tandem mass spectrometry;Update;Variant;Vascular Dementia;vascular risk factor;White Women;Woman;Women's Health;Work

PROJECT_TITLE: Metabolomic profile of chronic distress in relation to diseases of aging across diverse populations

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Heart Disease;Mental Health;Neurosciences;Prevention

ORG_CITY: FORT COLLINS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Narrative  Heart disease is the leading cause of death in the United States, and is frequently initiated or exacerbated by stress. In fact, both chronic stress exposure and heightened physiological reactivity to acute psychological stress are associated with increased cardiovascular mortality. Our preliminary data indicate that the rodent infralimbic prefrontal cortex reduces physiological stress responses and the goal of this proposal is to determine whether infralimbic projections to the brainstem prevent stress-induced cardiovascular pathology.

PI_NAMEs: MYERS, BRENT PHILIP (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Acute;acute stress;Address;Animals;Biological;biological adaptation to stress;Biological Process;Blood Pressure;Blood Vessels;Brain region;Brain Stem;burden of illness;Cardiac;Cardiovascular Diseases;cardiovascular effects;cardiovascular health;Cardiovascular Pathology;Cardiovascular system;Catecholamines;Cause of Death;Cells;Chronic;Chronic stress;Cognition;Cognitive;combinatorial;Corticosterone;Corticotropin;Data;Disease;Electrocardiogram;Endocrine;Endothelium;Enterobacteria phage P1 Cre recombinase;Epidemiology;Epinephrine;experience;experimental study;Exposure to;Female;Fiber Optics;Functional disorder;Gene Expression;Genes;glutamatergic signaling;Glutamates;Goals;Heart Diseases;heart function;Heart Hypertrophy;Heart Rate;heart rate variability;hemodynamics;Hormones;Hypertrophy;hypothalamic-pituitary-adrenal axis;in vivo;Incidence;Injections;knock-down;Life Stress;Light;Link;male;Measures;Medial;Mediating;Mediator;Mood Disorders;Morbidity - disease rate;mortality;mRNA Expression;Myography;nano-string;neural circuit;neuromechanism;Neurons;Neurosecretory Systems;Norepinephrine;novel;optogenetics;Output;Pathologic;Pathology;Pathway interactions;Physiological;Plasma;Population;Predisposition;Prefrontal Cortex;pressure;Presynaptic Terminals;prevent;Psychological Stress;Psychosocial Stress;Rattus;response;restraint;retrograde transport;Rodent;Role;Severities;Signal Pathway;Signal Transduction;Site;Stress;stress disorder;stress reactivity;Synapses;Telemetry;Testing;Tetanus Toxin;therapeutic target;ultrasound;United States;Vascular Diseases;Vascular Endothelium;vector;Viral

PROJECT_TITLE: Cortical-Medullary Circuitry Preventing the Cardiovascular Consequences of Chronic Stress

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: NARRATIVE Stress is linked to Alzheimer’s disease risk and progression but the ways by which stress increases Alzheimer’s disease risk is not well understood. This project will assess how exposure to a single stressful event affects biomarkers related to Alzheimer’s disease. Increasing our understanding of how a single stressful event affects Alzheimer’s disease biomarkers will help uncover how stress exposure earlier in life increases the risk for Alzheimer’s disease later in life.

PI_NAMEs: MATHER, MARA  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Acute;acute stress;Address;Adrenal Glands;Affect;aged;allostatic load;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Animal Model;Animals;biological adaptation to stress;Biological Markers;Blood specimen;Brain;Cerebrospinal Fluid;Correlation Studies;Deposition;Development;Disease;Disease Marker;Disease Outcome;disease phenotype;Disease Progression;Encephalitis;Endocrine;Etiology;Exposure to;Feedback;Functional disorder;Future;Glucocorticoids;glucose metabolism;Hand;heart rate variability;Hormones;Hour;Human;Hydrocortisone;hyperphosphorylated tau;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Ice;Impairment;Individual;insight;interstitial;Laboratories;Life;Link;Literature;longitudinal analysis;Measures;men;middle age;mild cognitive impairment;Nerve Degeneration;neuroinflammation;Observational Study;Participant;Pathogenesis;Pathway interactions;Patients;Persons;Physiological;Pituitary Gland;Pituitary-Adrenal System;Plasma;Play;Post-Traumatic Stress Disorders;Process;Production;Reaction;Recording of previous events;Reporting;Research;response;restraint stress;Role;Salivary;Series;social;Stress;Stressful Event;stressor;System;Testing;theories;Time;Translating;Veterans;Videotape;Water;Woman;Women's study;Work

PROJECT_TITLE: Effects of Acute Stress Exposure on Plasma beta-amyloid Levels

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Services;Lung;Patient Safety;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE More than 250,000 Americans develop acute pulmonary embolism each year, and nearly all are admitted to the hospital despite clinical evidence and guidelines recommending management at home for up to half of these patients. This study will evaluate a program to help Emergency Medicine clinicians in a diverse set of Michigan hospitals identify and discharge patients with acute pulmonary embolism for safe management at home. State-of-the-art implementation science frameworks and behavior change theories will be used to inform tailoring and multi-level evaluation, and set up infrastructure for national program dissemination that will help avoid nearly 100,000 unnecessary hospital admissions annually.

PI_NAMEs: BARNES, GEOFFREY DOUGLAS (contact);GREINEDER, COLIN FRED;SMITH, SHAWNA NICOLE

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Adherence;Admission activity;Adoption;Adverse event;Ambulatory Care;American;Anticoagulants;behavior change;behavioral economics;Behavioral Sciences;care delivery;Caring;Clinical;clinical decision-making;clinical practice;Conflict (Psychology);Data Collection;Decision Making;design;Development;Diagnosis;Disparity;Effectiveness;effectiveness study;Electronics;Elements;Emergency Department patient;Emergency Medicine;Ensure;Environment;Ethnic Origin;Evaluation;evidence base;evidence based guidelines;experience;follow-up;Guidelines;Health Care Costs;Health Resources;Health system;Healthcare;Hemorrhage;heuristics;Home;Hospital complications;Hospitalization;Hospitals;Hybrids;implementation determinants;implementation efforts;implementation evaluation;implementation framework;implementation intervention;implementation outcomes;implementation protocol;implementation science;implementation strategy;implementation trial;improved;improved outcome;Infrastructure;Insurance Coverage;interest;Intervention;Interview;Lead;Life;Link;Literature;Maintenance;Maps;Measures;Methodology;Michigan;Morbidity - disease rate;mortality;multi-component intervention;Oral;Outcome;Outpatients;Pathway interactions;Patient Discharge;patient oriented;Patient Preferences;patient safety;Patients;Pharmaceutical Preparations;point of care;Positioning Attribute;primary outcome;Process;program dissemination;programs;Publishing;Pulmonary Embolism;Race;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Resources;Retinal blind spot;Risk;Rural;Safety;safety outcomes;sex;Site;Specific qualifier value;suburb;success;supplemental oxygen;Testing;theories;Theory of Change;United States;user centered design

PROJECT_TITLE: Michigan Emergency Department Improvement Collaborative AltERnaTives to admission for Pulmonary Embolism (MEDIC ALERT PE) Study

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The brains of individuals with Parkinson's disease, dementia with Lewy bodies, and a significant portion of those with Alzheimer's disease gradually develop abnormal protein deposits called Lewy bodies, but it is not known how they form and contribute to disease. This study uses a recently discovered method that causes brain cells to form these lesions, allowing us to investigate which neurons in the brain are most affected by this disease process and how this type of pathology impairs the survival of these neurons. Better understanding of these processes would lead to a better understanding of disease progression and accelerate the development of new therapies for a host of neurodegenerative disorders such as Parkinson's, dementia with Lewy bodies, and Alzheimer's disease.

PI_NAMEs: LUK, KELVIN C (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Acceleration;Address;Affect;alpha synuclein;Alzheimer's Disease;Alzheimer's disease patient;Animal Model;Animals;Antisense Oligonucleotides;Atlases;Autopsy;Biological;Brain;brain cell;Brain Diseases;Brain Stem;Candidate Disease Gene;candidate marker;candidate validation;Cell Separation;Cells;Central Nervous System;computerized tools;connectome;Cytoplasm;Data;Dementia with Lewy Bodies;Deposition;Development;differential expression;Disease;disease model;Disease Progression;Distal;Dopamine;dopaminergic neuron;Early Diagnosis;Exposure to;Family;Funding;Gene Expression;gene expression database;Genes;Genetic;genetic risk factor;Histologic;Human;human disease;Impairment;in silico;in vivo;Individual;Infectious Agent;Injections;insight;knock-down;Knock-in;Knock-in Mouse;Knock-out;Label;Lesion;Lewy Bodies;Lewy body pathology;Lewy neurites;Libraries;Link;Literature;locomotor deficit;Maps;mathematical methods;mathematical model;Measures;Mediating;Methods;misfolded protein;Modeling;Molecular;Molecular Profiling;motor impairment;Mus;Mutation;Nerve Degeneration;Neuroanatomy;Neurodegenerative Disorders;Neurologic Symptoms;neuron loss;neuronal survival;Neurons;nonhuman primate;novel;novel therapeutics;Oxidative Stress;Parkinson Disease;pars compacta;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Pattern;Peripheral Nervous System;permissiveness;Population;pre-formed fibril;Predisposition;Prion Diseases;Process;Proteins;Rattus;Recombinants;Reporting;Resistance;risk variant;single-cell RNA sequencing;Site;SNCA gene;spatiotemporal;Structure;Substantia nigra structure;synucleinopathy;Testing;Time;Tissues;tool;Toxic effect;Tracer;transcriptome sequencing;virtual;Wild Type Mouse

PROJECT_TITLE: Propagation of Lewy pathology in Parkinson's and related disorders


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;West Nile Virus

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: BIOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Mosquito-borne flaviviruses present a significant global health burden, with Dengue, West Nile and Zika viruses causing millions of infections and thousands of deaths annually. A better understanding of the viral surface will aid structure-based pharmaceutical design efforts to develop more effective treatments and safer vaccines. This proposal describes research to characterize poorly understood heterogeneity in the viral surface lattice of E proteins, combining novel technologies and analyses to improve structural models and antibody neutralization stoichiometry predictions, and clearly establishing which lattice arrangements are most important for infectivity.

PI_NAMEs: METSKAS, LAUREN ANN  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Adhesions;Affect;Affinity;Antibodies;Antibody Affinity;Antibody-Dependent Enhancement;Area;Behavioral;Binding;Biomedical Engineering;carbon fixation;Cardiac Muscle Contraction;Cell membrane;Cell surface;Cells;Cessation of life;Characteristics;Chemotaxis;Clinical;Cryo-electron tomography;Cryoelectron Microscopy;Cytoplasm;Dengue;Dengue Virus;design;Development;dimer;Disease;Drug Design;E protein;effective therapy;Endocytosis;endosome membrane;Endosomes;Environment;Epitope Mapping;Epitopes;Evolution;experience;Flavivirus;Genome;global health;Glycoproteins;Goals;Health;Heterogeneity;Human;Hydrophobicity;Image;imaging capabilities;Immune response;improved;In Situ;In Vitro;Individual;Infection;insight;Kinetics;late endosome;Left;Life;Light;Measurement;Mechanics;Membrane;Membrane Fusion;Methodology;Methods;Modeling;Molecular Conformation;monomer;mosaic;mosaic pattern;mosquito-borne;Mutation;neutralizing antibody;new technology;novel strategies;Pattern;Pharmacologic Substance;Physiological;Play;Population;Positioning Attribute;prevent;Process;Protein Array;Proteins;receptor;receptor binding;Research;Role;Sampling;Side;Site;small molecule;Source;stem;stoichiometry;structural biology;Structural Models;Structure;Structure-Activity Relationship;Surface;Tail;Target Populations;Techniques;Technology;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutically effective;tool;Vaccine Design;Vaccines;Viral;Viral Antibodies;viral RNA;Virion;Virus;Visualization;West Nile virus;Work;Zika Virus

PROJECT_TITLE: Partial maturation in mosquito-borne flaviviruses: developing new approaches to characterize the role of lattice heterogeneity in fusion, infectivity, and antibody neutralization


ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Aneurysmal subarachnoid hemorrhage (aSAH) occurs in approximately 50,000 patients per year in the U.S. and causes considerable morbidity and mortality. Aneurysmal rupture triggers a robust and dysregulated systemic proinflammatory response; however, the systemic metabolic response has not been described. This project seeks to define the systemic metabolic abnormalities occurring early after aSAH using a metabolomic based approach and will investigate metabolically targeted treatments that improve innate immune system oxidative metabolism.

PI_NAMEs: GUSDON, AARON MARK (contact)

PROGRAM_OFFICER_NAME: KOENIG, JAMES I

PROJECT_TERMS: Affect;alpha ketoglutarate;Aneurysmal Subarachnoid Hemorrhages;Anti-Inflammatory Agents;Attenuated;Basic Science;Bioinformatics;Biological Assay;biomedical informatics;Blood specimen;Body System;Brain Injuries;CCL3 gene;Cell Respiration;Cerebral Ischemia;Citrates;Citric Acid Cycle;Clinical;clinical center;Clinical Sciences;cohort;cytokine;Data;Dedications;Development;Disease;Educational Curriculum;effective therapy;Effector Cell;extracellular;fatty acid oxidation;Flow Cytometry;Fumarates;functional outcomes;Genus Hippocampus;Glutamine;Glycolysis;Heart;Hemorrhage;Hospitals;Hour;IL8 gene;immune activation;Impairment;improved;improved outcome;Individual;Inflammation;Inflammatory;Inflammatory Response;Innate Immune System;Interleukin-6;Kidney;Leukocytes;Lung;machine learning model;Mass Spectrum Analysis;Measures;Medical;medical schools;Membrane Potentials;Mentorship;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Metformin;Methods;Mitochondria;mitochondrial membrane;monocyte;Morbidity - disease rate;mortality;Operative Surgical Procedures;Outcome;outcome prediction;Oxidative Phosphorylation;Patients;Peripheral;peripheral blood;Persons;Phenotype;Physicians;Plasma;predict clinical outcome;predictive modeling;Predisposition;prevent;Production;prospective;Research Proposals;Respiration;response;Risk;Rupture;Ruptured Aneurysm;Sampling;Schools;Scientist;Sepsis;Severities;Severity of illness;systemic inflammatory response;targeted treatment;Therapeutic Intervention;Time;TNF gene;Training;Translational Research;Tricarboxylic Acids;Validation;Vasospasm

PROJECT_TITLE: Metabolic alterations after aneurysmal subarachnoid hemorrhage

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Huntington’s disease (HD) is a neurodegenerative disorder exhibiting progressive motor and cognitive decline where medium spiny neurons (MSNs) of the striatum are preferentially affected. This proposal aims to determine the molecular pathways that lead to MSN transcriptional dysregulation and degeneration, and to identify potential therapeutic targets to ameliorate or even prevent MSN death during HD progression.

PI_NAMEs: GOMEZ-PASTOR, ROCIO  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Address;Affect;Behavioral;Binding Sites;Biochemical;biological adaptation to stress;Brain;Brain region;CAG repeat;Cell model;Cell Survival;cell type;Cells;Corpus striatum structure;Cyclic AMP-Dependent Protein Kinases;Data;Degradation Pathway;Dependence;Dependovirus;Disease;Disease Progression;Energy Metabolism;Exhibits;Functional disorder;Future;Gene Expression;Genes;genetic manipulation;Genetic Transcription;Goals;Heat Losses;heat shock transcription factor;Huntington Disease;Huntington gene;Impaired cognition;improved;improved outcome;Injections;Intervention;Knock-out;Knockout Mice;Mediating;Mitochondria;mitochondrial dysfunction;Molecular;Molecular Chaperones;Motor;mouse model;Mus;mutant;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neuronal Dysfunction;Neurons;neuropathology;Nucleic Acid Regulatory Sequences;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Predisposition;prevent;Process;programs;protein aggregation;Protein Kinase;Proteins;restoration;Role;Satellite Viruses;Signal Transduction;small hairpin RNA;spatiotemporal;Stress;Symptoms;synergism;Tamoxifen;Testing;Therapeutic;therapeutic target;Time;TP53 gene;transcription factor;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;ubiquitin-protein ligase;United States;Up-Regulation

PROJECT_TITLE: Cell Signaling Dysregulation in Huntington's Disease


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Childhood Injury;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Rare Diseases;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Head CT has been widely used in pediatric patients for the diagnosis of cranial fractures in head trauma and cranial suture patency in craniosynostosis, a congenital disability defined by a prematurely fused cranial suture. Unfortunately, these pediatric patients are particularly vulnerable to ionizing radiation from CT scans. Moreover, sedation is commonly used to reduce motion artifacts in children. Our proposal will develop a motion-robust, fast, and fully automated approach to perform high resolution 3D cranial bone imaging using MR as a safe alternative. The proposed research is relevant to public health as it will have a profound impact on pediatric patients by reducing the risks associated with ionizing radiation and sedation for cranial bone imaging. If successful, this study will achieve a goal set by the National Cancer Institute, American College of Radiology, and US Food and Drug Administration (FDA) by reducing radiation exposure in children from head CT scans.

PI_NAMEs: AN, HONGYU  (contact);PATEL, KAMLESH

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;Accident and Emergency department;Address;Adoption;Adult;age related;American College of Radiology;Bayesian neural network;Black race;bone;bone imaging;Bone Marrow;brain tissue;Cardiopulmonary;Cephalic;Child;Childhood;Clinical;clinical care;clinical diagnosis;clinical practice;clinical translation;Consensus;Craniocerebral Trauma;Craniosynostosis;cranium;Data;deep learning;Development;Developmental Delay Disorders;Diagnosis;diagnostic tool;disability;Enrollment;Evaluation;follow-up;Fracture;Goals;Head;Health;Image;image processing;image reconstruction;imaging modality;indexing;Ionizing radiation;Joint structure of suture of skull;Legal patent;leukemia;Magnetic Resonance Imaging;Malignant neoplasm of brain;Manuals;Maps;Medical center;Methods;Modeling;Morphologic artifacts;Motion;Movement;National Cancer Institute;Noise;novel;Patient risk;patient subsets;Patients;pediatric patients;Pilot Projects;Postoperative Care;Postoperative Period;premature;Public Health;Radiation;Radiation exposure;radiation risk;Radiation Tolerance;Rapid diagnostics;reconstruction;Reporting;Research;Resolution;Risk;Safety;Scanning;Sedation procedure;Signal Transduction;skull base;Skull Fractures;success;Surgical sutures;Techniques;temporal measurement;Time;Tissues;transfer learning;Translating;Trauma;Uncertainty;United States;United States Food and Drug Administration;Work;X-Ray Computed Tomography

PROJECT_TITLE: Robust and Rapid 3D High-Resolution Cranial bone imaging for pediatric patients using MRI


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Epilepsy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Current surgical options for intractable epilepsy result in continued seizures in 30-60% of cases. New research, including our own, suggests that quantitative analysis of the interictal EEG — time periods between seizures — can localize seizure generators and may help improve surgical planning. The goals of this study are to determine the spatiotemporal characteristics of two alternate quantitative methods of analyzing interictal EEG, to test whether these methods accurately localize seizure generators, and to determine if probing the interictal EEG with electrical stimulation improves localization.

PI_NAMEs: CONRAD, ERIN  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Agreement;Biometry;Brain;career;career development;Caring;Characteristics;Classification;Clinical;clinically relevant;Computing Methodologies;Data;data acquisition;Data Analyses;Data Collection;Educational workshop;Electric Stimulation;Electrodes;Electroencephalography;Enrollment;Epilepsy;epileptiform;Evaluation;Evoked Potentials;Excision;experience;Goals;graph theory;Implant;improved;instructor;Intractable Epilepsy;Knowledge;Machine Learning;machine learning algorithm;Manuals;Measurable;Measurement;Measures;meetings;Mentors;Methods;Monitor;multimodality;National Institute of Neurological Disorders and Stroke;Nature;neuroimaging;Neurons;Neurosciences;novel marker;Operative Surgical Procedures;Outcome;outcome prediction;Patient-Focused Outcomes;Patients;Pennsylvania;Persons;Physicians;predicting response;Process;programs;prospective;Prospective cohort;Publications;Recurrence;Research;Resected;response;Retrospective cohort;Scientist;Seizures;Series;skills;Source;spatiotemporal;statistics;surgery outcome;Testing;theories;Therapeutic Uses;Time;Training;Universities;Vertebral column;Work

PROJECT_TITLE: Quantitative interictal networks to localize seizure generators


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Precision Medicine

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Heart Failure with Preserved Ejection Fraction (HFpEF) is a common syndrome with few effective therapies, due to its multiple phenotypes and our poor understanding of its pathobiology. The current proposal will use bioinformatics to analyze cell-specific and metabolic abnormalities in heart tissue and blood samples from patients with HFpEF. The work is highly translational and will guide efforts to match subgroups to appropriate precision therapies for this major unmet medical need.

PI_NAMEs: HAHN, VIRGINIA SHALKEY (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Address;Affect;American;Animal Model;Autophagocytosis;Bioinformatics;Biological;Biological Assay;Biopsy;Blood specimen;Cardiac Myocytes;Cardiology;Cardiometabolic Disease;Cardiovascular system;career;career development;Caring;cell type;Cells;Clinical;clinical phenotype;Clinical Trials;clinically relevant;cohort;comorbidity;comparison control;Coronary sinus structure;Data;Depressed mood;Development;Development Plans;Disease;effective therapy;EFRAC;Endothelial Cells;Environment;Enzymes;Exclusion;exercise capacity;Exhibits;experience;Extracellular Matrix;fatty acid oxidation;Fatty Acids;Fellowship;Fibroblasts;Generations;Genes;Glucose;Goals;Heart;heart dimension/size;Heart failure;heart metabolism;hemodynamics;Heterogeneity;Human;human RNA sequencing;human subject;human tissue;Hypertrophy;imaging study;Immune;in vivo;individualized medicine;Inflammatory;inhibitor;insight;Institution;International;Investments;K-Series Research Career Programs;Knowledge;Learning;Left Ventricular Hypertrophy;Master of Science;Measures;Medical;medical schools;Medicine;Mentors;Metabolic;metabolic profile;Metabolism;metabolomics;Mission;Modeling;Molecular;Morbid Obesity;multiple omics;Myocardial;Myocardium;National Heart, Lung, and Blood Institute;Natriuretic Peptides;non-invasive imaging;novel therapeutics;Nuclear RNA;Obesity;oxidation;Oxidative Phosphorylation;Pathway interactions;Patients;Pattern;peripheral blood;Phenotype;Physicians;Positioning Attribute;Postdoctoral Fellow;Precision therapeutics;preservation;Prevalence;professor;programs;protein expression;Proteins;Proteomics;Protocols documentation;Publishing;Recycling;Reporting;Research;Research Personnel;Risk Factors;Role;Sampling;Scientist;Serum;single cell analysis;single nucleus RNA-sequencing;skills;Sodium;stem;Subgroup;success;symporter;Syndrome;Testing;Tissue Sample;Tissues;Training;Transcript;transcriptomics;Translational Research;United States National Institutes of Health;Universities;uptake;Ventricular Remodeling;Virginia;Woman;women patients;Work

PROJECT_TITLE: Analysis of Single Cell Transcriptomics and Cardiac Metabolism in Heart Failure with Preserved Ejection Fraction

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

PHR: PROJECT NARRATIVE Because of the harms/benefit ratio for prostate cancer screening, clinical guidelines generally recommend against universal PSA screening for men but do call for shared decision making (SDM). SDM involves discussing the benefits and harms of medical interventions and incorporating patient preferences into decisions. The next frontier in cancer screening is a new paradigm of precision screening, in which an individual’s genetic make-up may be used to stratify their level of future cancer risk and inform whether, how early, and how often they should be screened. Both precision screening and SDM are part of the Cancer Moonshot v2.0. This also has implications for SDM, as Veterans and providers will need to integrate this new type of information into decisions. We propose to identify the most effective ways by which primary care in VHA can make shared decision making a routine part of their usual care.

PI_NAMEs: CLAYMAN, MARLA L. (contact);VASSY, JASON L

PROJECT_TERMS: Address;black men;Black race;BRCA2 gene;Breast;Cancer Center;cancer initiation;cancer risk;Caring;Cessation of life;Clinical;clinical risk;Colorectal;Competence;Decision Making;Development;Diagnosis;disorder prevention;Disparity;Equity;Evaluation;Family;frontier;Future;Genetic;Genetic Counseling;genetic makeup;genome wide association study;Goals;Guidelines;Harm Reduction;Health;Health Promotion;Healthcare;Healthcare Systems;high risk;implementation barriers;implementation strategy;Individual;innovation;Intervention;intervention mapping;Interview;Knowledge;Lead;Learning;literate;Lung;lung cancer screening;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;Medical Care Team;member;men;Methodology;Modeling;Morbidity - disease rate;mortality;multi-component intervention;Names;Nurses;patient oriented;Patient Preferences;Patients;personalized screening;Policies;polygenic risk score;Population;population based;preservation;President's Cancer Panel;Primary Care;primary care provider;primary care team;Process;prostate cancer risk;Provider;PSA screening;racial discrimination;racial diversity;Recommendation;Recording of previous events;Risk;Risk Estimate;Risk Factors;screening;Screening for cancer;Screening for Prostate Cancer;screening guidelines;screening program;Self Efficacy;shared decision making;skills;Surveys;System;Team Nursing;Testing;therapy development;treatment as usual;unnecessary treatment;Variant;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Building a shared decision making implementation strategy for the emerging paradigm of precision cancer screening

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: VA is a national leader in the provision of high-quality hospice and palliative care, particularly in VA Community Living Centers (CLCs). Yet the demand for CLC-based hospice care has outpaced supply, a gap that is expected to increase with the aging of the Veteran population. To address this need, VA contracts with community nursing homes (CNHs) and hospice agencies to provide CNH-based hospice care to Veterans. Our preliminary work has revealed that quality ratings of EOL care provided in CNHs are soberingly lower than in VA CLCs. Thus, VA must identify ways to improve quality of EOL care in CNHs. This novel project uses a mixed methods design to develop a rich understanding of the structural characteristics and care processes that are associated with the provision of high-quality CNH-based hospice care. The results will be used to inform policies and practices that improve the quality of EOL care provided in CNHs.

PI_NAMEs: KUTNEY LEE, ANN ;WACHTERMAN, MELISSA  (contact)

PROJECT_TERMS: Address;Administrator;Age;Aging;Area;Beds;Caring;Characteristics;Clinical;Collaborations;Communication;Communities;Community Healthcare;community living;Complex;Contracts;dashboard;Data;Data Sources;design;Development;end of life;end of life care;Ensure;Family;Family member;Future;Geriatrics;Goals;Home;Hospice Care;hospice environment;Hybrids;improved;innovation;Inpatients;Intervention;Intervention Studies;Interview;Learning;Life;Link;Logistic Regressions;Long-Term Care;Machine Learning;machine learning method;Measures;Methodology;Methods;military veteran;Modeling;novel;Nursing Homes;Ownership;Palliative Care;Patients;Perception;Performance;Phase;Play;Policies;Predictive Factor;Process;programs;Quality of Care;recovery house;Reporting;Research;response;Role;Services;Strategic Planning;Structure;Surveys;Trees;Variant;Veterans;Work

PROJECT_TITLE: Improving Quality of End-of-Life Care for Veterans Receiving Hospice in Community Nursing Homes

STUDY_SECTION_NAME: HSR-6 Aging, Recovery, and Workforce[HSR6]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Pain Research;Primary Health Care;Rural Health;Social Determinants of Health

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE Chronic pain is a major health concern and places an enormous burden on society and healthcare systems in the U.S., especially in rural areas. This project aims to plan and test auricular point acupressure self- management (APA-SM) integrated into primary care. We will conduct a real-world trial to evaluate clinical effectiveness, implementation outcomes, and cost-effectiveness toward revolutionizing pain management particularly for rural populations.

PI_NAMEs: BOLIN, JANE N;KAWI, JENNIFER  (contact);WU, HULIN

PROGRAM_OFFICER_NAME: WEBER, WENDY J

PROJECT_TERMS: Acupressure;Acupuncture Therapy;Address;Adherence;Adopted;Adult;Advocate;Analgesics;arm;behavior change;cancer pain;Caring;Cellular Phone;chronic musculoskeletal pain;chronic pain;chronic pain management;Clinic;Clinical;Clinical effectiveness;Clinical Management;clinical pain;clinical practice;Collaborations;collaboratory;Collection;Common Core;Common Data Element;Communities;community partners;comorbidity;comparison control;Computers;Cost Analysis;cost effectiveness;cost-effectiveness ratio;Data;Demographic Factors;design;digital;disability;Disparity;Ear;Ecological momentary assessment;Education;Educational process of instructing;effectiveness evaluation;effectiveness outcome;effectiveness/implementation hybrid;effectiveness/implementation trial;Electronic Health Record;Eligibility Determination;empowerment;Enrollment;Ensure;Equity;Event;evidence base;Evidence based intervention;Exhibits;flexibility;follow-up;Fostering;geographic population;Goals;Guidelines;Headache;Health;health care settings;health equity;Health Services Accessibility;Healthcare;Healthcare Systems;implementation cost;implementation evaluation;implementation outcomes;improved;incremental cost-effectiveness;Individual;innovation;Intervention;Learning;Maintenance;Measures;medical specialties;Methods;Migraine;Modeling;Monitor;Motivation;Musculoskeletal Pain;Nonpharmacologic Therapy;opioid epidemic;opioid use;Outcome;Pain;Pain intensity;Pain interference;Pain management;pain outcome;pain reduction;pain self-management;Participant;Patient Compliance;patient health information;Patient Preferences;Patient-Centered Care;Patients;Persons;Pharmaceutical Preparations;Phase;Physical Function;pilot test;population health;Population Heterogeneity;pragmatic trial;Predictive Factor;Primary Care;primary care setting;primary outcome;Procedures;programs;Protocols documentation;Provider;Public Health;Quality Control;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;recruit;Reporting;Research;Resources;response;routine care;Rural;rural area;rural disparities;Rural Health;rural healthcare;Rural Population;Sample Size;satisfaction;secondary outcome;Self Administration;Self Efficacy;Self Management;self-management program;skills;Societies;South Carolina;statistical and machine learning;System;Tablets;Testing;Texas;theories;Therapeutic;Time;Training;treatment as usual;treatment response;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Personalized Auricular Point Acupressure for Chronic Pain Self-Management in Rural Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 SN (09)]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

PHR: Veterans develop Parkinson’s disease at a higher rate than the general population. Parkinson’s disease is a progressive condition with no known cure. Drug treatments work for a while but often fail as the disease progresses. Deep brain stimulation can help alleviate motor symptoms but requires invasive implant surgery, and side effects can limit its effectiveness. The goal of this project is to develop better ways to treat motor symptoms of Parkinson’s disease using somatosensory stimulation as a less invasive or non-invasive way to produce beneficial changes in brain network signaling. In this study, a rat model of Parkinson’s disease will be used to compare different stimulation patterns and sensory targets and if stimulation should be applied continuously or in response to certain brain states. The technology developed and refined on this grant could provide a safer way to more effectively reduce Parkinson’s symptoms with fewer side effects.

PI_NAMEs: TAYLOR, DAWN MARIE (contact)

PROJECT_TERMS: Area;Back;Brain;brain surgery;Chemical Exposure;Chronic;Clinical;combat;Cortical Synchronization;Cutaneous;Deep Brain Stimulation;design;Disease;Dopamine;Effectiveness;Electrodes;excitotoxicity;Exhibits;experience;Feedback;Frequencies;Future;General Population;Goals;Grant;Hindlimb;Human;Implant;improved;Incidence;Limb structure;military veteran;minimally invasive;Modeling;Monitor;Motor;Motor Activity;Motor Cortex;motor symptom;Movement Disorders;Muscle;neural;neural circuit;neural implant;Neurodegenerative Disorders;Neurons;neuroprotection;Neurotoxins;novel;Operative Surgical Procedures;Oxidopamine;Parkinson Disease;Parkinsonian Disorders;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Performance;Peripheral;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase;phase change;Physiologic pulse;Production;Randomized;Rattus;receptor;Records;response;Risk;Sensory;sensory input;side effect;Signal Transduction;Skin;somatosensory;Somatosensory Receptor;subcutaneous;symptom management;symptomatic improvement;Symptoms;Synapses;Technology;Testing;Therapeutic;Time;Tremor;Veterans;Work

PROJECT_TITLE: Somatosensory stimulation therapies for movement disorders

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Gene Therapy;Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE This project will use lentiviral vectors guided by an antibody to human CD7 to deliver Cas9/gRNA effector molecules to inactivate the HIV proviral DNA in latently-infected human T cells. The significance is a clinically- viable non-invasive systemic approach to kill HIV without otherwise affecting the infected cell.

PI_NAMEs: KUMAR, PRITI  (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;Affinity;Antibodies;antiretroviral therapy;Automobile Driving;Binding;CCR5 gene;CD7 gene;Cell Line;Cell model;Cell Physiology;Cells;Clinical;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;CRISPR/Cas technology;CXCR4 gene;design;Detection;Dimensions;Disabling;Disease remission;DNA;DNA Integration;Dose;emerging virus;Future;Gene Delivery;gene discovery;gene therapy;gene-editing approach;Genetic Transcription;Genome;Goals;Guide RNA;hematopoietic tissue;HIV;HIV-1;HIV/AIDS;Human;humanized antibody;humanized mouse;Immune system;immunogenicity;improved;in vivo;Individual;Infection;innovation;Interruption;Intervention;Investigation;latent HIV reservoir;latent virus activation;Length;Lentivirus;Lentivirus Vector;Measurement;Methodology;Mutate;nanobodies;next generation sequencing;nonhuman primate;novel;nuclease;Outcome;Patients;pre-clinical;Provirus Integration;Proviruses;reactivation from latency;receptor;Regimen;response;Rest;Ribonucleoproteins;RNA;RNA delivery;Shock;siRNA delivery;Solid;Sorting;System;T memory cell;T-Lymphocyte;targeted delivery;Technology;Testing;Therapeutic;therapeutic gene;Toxic effect;Translating;Tropism;vector;Viral;viral rebound;Viral reservoir;Viremia;virtual;Virus;Virus Activation;Virus Latency;Virus Replication;virus testing;Withdrawal

PROJECT_TITLE: T cell-targeted lentiviral vectors with Cas9/RNP for the in vivo gene therapy of HIV-AIDS


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Gene Therapy;Genetics;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: PROJECT NARRATIVE Non-healing bone fractures are a significant source of personal, economic, and healthcare system burden, especially in elderly populations. mRNA is emerging as a new strategy for regenerative medicine but may be improved with biomaterial carriers. This proposal will characterize mineral coated microparticles as a vehicle to decrease the reliance of mRNA therapeutics on freezers and for mRNA stimulation of bone defect healing.

PI_NAMEs: CHOE, JOSHUA ALAN (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acceleration;Adjuvant Therapy;Affinity;age related;Aging;Agonist;Animals;Archaeology;Autologous;Autologous Transplantation;Binding;Biocompatible Materials;Biomechanics;Biomimetics;BMP2 gene;bone;bone healing;Bone Injury;Bone Marrow;Bone Marrow Aspiration;Bone Regeneration;calcium phosphate;career;Cells;Characteristics;Clinical;Cold Chains;Communication;Complex;COVID-19 vaccine;Cryopreservation;Cues;cytotoxicity;Defect;Developmental Biology;disabled;DNA;Dose;Dose Limiting;Economics;effective therapy;Elderly;Evaluation;Fellowship;Fossils;Fracture;Freeze Drying;Gene Expression;gene therapy;Goals;Growth Factor;Harvest;healing;Healthcare Systems;high risk;Histologic;Human;improved;In Vitro;Incidence;ineffective therapies;Inflammation;Inflammatory;Infrastructure;Injury;innovation;interest;Laboratories;long bone;Measures;Mediating;Medical;Mentorship;mesenchymal stromal cell;Messenger RNA;Methods;mineralization;Minerals;minimally invasive;Modeling;mRNA delivery;mRNA Stability;Muscle;Musculoskeletal;Myoblasts;myogenesis;Nanostructures;Natural regeneration;neuromuscular;non-viral gene delivery;novel therapeutics;nucleic acid-based therapeutics;Nucleic Acids;older adult;older patient;Operative Surgical Procedures;Orthopedics;Osteogenesis;osteogenic;Outcome;particle;Pathological fracture;patient variability;Patients;Phenotype;Physicians;Population;Post-Translational Protein Processing;pre-doctoral;preservation;Procedures;Production;protective effect;protein folding;Protein Isoforms;Proteins;radiological imaging;Rattus;recombinant human bone morphogenetic protein-2;Recombinants;Recovery;regenerative approach;regenerative biology;Regenerative Medicine;repaired;research and development;Resources;response;Role;Scientist;side effect;skills;soft tissue;Source;Structure;Surface;Temperature;Testing;Therapeutic;Tissues;Training;Transfection;Universities;Wisconsin;WNT Signaling Pathway;Work

PROJECT_TITLE: Mineral Coated Microparticles for Stabilization and Delivery of Complexed mRNA  for Healing of Long Bone Defects


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: LINCOLN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

PHR: NARRATIVE The proper response of the immune system to pathogens is governed by complex, network-like interactions among various types of cells and their associated communication mediators. Computational systems modeling provides the ability to describe and interrogate the dynamics of these complex systems with the objective to identify and design more sophisticated and effective drug therapies. This funding will enable us to continue to develop a “Virtual Immune System” -- a multi-cellular and multi-scale model of the human immune system -- to study the properties of the immune system, investigate immune-related diseases, and make predictive modeling software technologies more accessible to the broad scientific community (including immunologists, computational biologists, and translational researchers).

PI_NAMEs: HELIKAR, TOMAS  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Behavior;Biochemical;Biological;Biological Markers;Biological Models;Brain;CD4 Positive T Lymphocytes;cell type;Cells;Collaborations;Communication;Communities;Complex;computer framework;Computer software;cost;COVID-19;cytokine;data-driven model;Decision Making;design;Dimensions;Disease;drug discovery;Education;effective therapy;Etiology;Funding;Gene Expression Regulation;Human;human model;Immune;Immune response;Immune system;Immunological Models;Immunologist;Interdisciplinary Study;International;Laboratories;Mediator;Metabolism;Methods;Modeling;multi-scale modeling;Multiomic Data;Nature;pathogen;Pathology;Pharmacotherapy;predictive modeling;programs;Property;Reproducibility;Research;Research Personnel;response;simulation;Software Engineering;Stimulus;System;Technology;Time;translational scientist;virtual;Visualization;Work

PROJECT_TITLE: Multi-cellular and multi-scale systems modeling to understand the dynamics of the human immune system in interdisciplinary applications

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Brain Disorders;Hearing Loss;Infectious Diseases;Neurodegenerative;Neurosciences;Otitis Media

ORG_CITY: STANFORD

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Chronic suppurative otitis media (CSOM)—i.e., discharging infected ears—is a significant world health problem with no effective therapy that is the most common cause of permanent hearing loss among children in the developing world. Pseudomonas aeruginosa (PA), a leading bacterial cause of CSOM, invades the middle ear and establishes itself into a difficult-to-treat biofilm, but it is not yet known how this bacterial invasion leads to inner ear hearing loss. We aim to use our novel CSOM mouse model to determine the timing and nature of structural changes and macrophage distribution occurring within the cochlea, identify potential hair cell toxins and macrophage inducers, and investigate the contributions of resident and migrating macrophages to CSOM hair cell death and sensory hearing loss, which may lead to new strategies for preventing permanent hearing loss in CSOM.

PI_NAMEs: SANTA MARIA, PETER LUKE (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: acute infection;Animal Model;Antibiotic Therapy;Appearance;Bacteria;Bacterial Infections;Bone Marrow Transplantation;Brightfield Microscopy;Cd68;Cell Death;cell injury;Cells;Chemicals;Child;Chimera organism;Chronic;Cochlea;Confocal Microscopy;cytokine;Data;Development;Disease;Dose;Ear;effective therapy;Fluoroquinolones;Foundations;Functional disorder;Future;Hair Cells;hearing impairment;Human;human disease;Immune;Immunohistochemistry;Infection;Infiltration;Inflammasome;Injury;Invaded;Investigation;Kinetics;Knock-out;Knockout Mice;Labyrinth;Liquid substance;Location;Macrophage;Macrophage Activation;Mediating;Medical;Microbial Biofilms;middle ear;middle ear fluid;migration;Modeling;Monitor;monocyte;mouse model;Mouse Strains;Mus;Nature;neglect;neglected tropical diseases;novel;novel strategies;Otitis Media;Outer Hair Cells;Pattern;Perilymph;permanent hearing loss;Persons;Phagocytes;Pharmacotherapy;Phenotype;polymicrobial biofilm;Population;prevent;prevent hearing loss;Process;Pseudomonas aeruginosa;Reaction;Reactive Oxygen Species;recruit;Reporter Genes;Role;Sampling;Scanning Electron Microscopy;Secondary to;Sectioning technique;Sensorineural Hearing Loss;Signal Transduction;Suppurative Otitis Media;Testing;Therapeutic Intervention;Time;Topical Antibiotic;Toxin;Transgenic Organisms;Transmission Electron Microscopy;Tympanic membrane;United States National Institutes of Health;Waxes;World Health

PROJECT_TITLE: The role of macrophages in chronic suppurative otitis media associated sensory hearing loss

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

PHR: PROJECT NARRATIVE Current methods of ascertaining complications after percutaneous coronary interventions (PCI) or ‘stent procedures’ are resource intensive and inadequate. This proposal aims to create and validate hybrid algorithms which use structured and unstructured data from the electronic health record leveraging natural language processing techniques, to reliably detect two important post-PCI events – in-hospital bleeding and 1- year target lesion revascularization. These algorithms will be incorporated into an automated routine which generates scheduled reports on these complications.

PI_NAMEs: MURUGIAH, KARTHIK  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: adjudication;Adoption;Algorithms;automated algorithm;Award;Back;Blood Transfusion;Cardiac;Cardiac Catheterization Procedures;Cardiovascular system;Career Choice;Clinical;Clinical Informatics;clinical outcome measures;Clinical Trials;Collaborations;comparative effectiveness study;comparative effectiveness trial;Computational Linguistics;Custom;Data;data integration;data lake;data registry;Data Set;Data Sources;deep learning;Derivation procedure;Detection;disease registry;Electronic Health Record;electronic health record system;Event;experience;Feedback;Generations;Goals;Health;health information technology;Health Sciences;Health system;Healthcare Systems;Hemorrhage;Hospitalization;Hospitals;Hybrids;Image;improved;Individual;information model;Institution;Knowledge;Laboratories;Lesion;Manuals;Measurement;Medical Informatics;Mentors;Mentorship;Methods;Monitor;Morbidity - disease rate;mortality;multidimensional data;Myocardial Ischemia;Natural Language Processing;Natural Language Processing pipeline;Observational Study;open source;Outcomes Research;Patients;percutaneous coronary intervention;Performance;portability;Positioning Attribute;Pragmatic clinical trial;predictive modeling;Procedures;Process;prospective;Provider;quality assurance;Reporting;Research Personnel;Resources;restenosis;revascularization;Risk;risk prediction model;Safety;Schedule;Signal Transduction;Site;skills;Source;Standardization;stent thrombosis;Stents;Structure;structured data;supervised learning;support tools;Surveys;Techniques;Testing;Text;Time;tool;Training;training data;training opportunity;unstructured clinical data;unstructured data;Work

PROJECT_TITLE: Automated ascertainment of bleeding and target lesion revascularization after percutaneous coronary intervention (PCI) using electronic health record (EHR) data

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: CHAPEL HILL

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative Pertussis (aka whooping cough) is a serious childhood disease that is re-emerging in developed countries despite high vaccine coverage, due to inadequacies of current acellular (aP) pertussis vaccines. We are investigating how two major Bordetella virulence factors, filamentous hemagglutinin (FHA) and adenylate cyclase toxin (ACT), cooperate to minimize inflammation and inactivate host phagocytes, contributing to bacterial persistence in the lower respiratory tract. Our results will provide insight needed to develop more efficacious vaccines and therapeutics.

PI_NAMEs: COTTER, PEGGY A (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Acellular Vaccines;Adenylate Cyclase Toxin;Adherence;Adolescent and Young Adult;Affect;Animal Model;Bacteria;Bacterial Adhesins;Binding;Biochemical;Biological;Biological Assay;Bordetella;Bordetella bronchiseptica;Bordetella pertussis;Bordetella Virulence Factors;C-terminal;Cell Culture Techniques;Cell surface;Cells;Childhood;Developed Countries;Development;Disease;Epithelial Cells;Event;experimental study;Family;Genetic;Goals;Hemagglutinin;Human;Immunity;Immunize;Infant;Infection;Inflammation;Inflammatory Response;insight;Lipoprotein (a);Lower respiratory tract structure;Macrophage-1 Antigen;Maintenance;Mammalian Cell;Mammals;Mediating;member;Modeling;Molecular;Mus;novel vaccines;pathogen;Peptide Hydrolases;periplasm;Pertussis;Pertussis Vaccine;Phagocytes;Play;prevent;protein function;Protein Secretion;Proteins;Rattus;receptor;Respiratory Tract Infections;response;Risk;Role;Series;Signal Transduction;Surface;System;Testing;Therapeutic;Toxin;transmission process;Vaccination;Vaccines;Virulence;Virulence Factors;Work

PROJECT_TITLE: Cooperative roles of FHA and ACT in Bordetella virulence

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

ORG_STATE: IL

PHR: Project narrative Arm and hand function is impaired in a number of veterans with cervical spinal cord injury. This proposal aims to use transcutaneous electrical spinal stimulation (TESS) in a task-specific manner to maximize the recovery of arm and hand function and combined this novel approach with motor training using a closed-loop control strategy. Because deficits in hand control are a major problem after stroke, amyotrophic lateral sclerosis, multiple sclerosis, and other motor disorders, our work may also be relevant for veterans with other lesions of the CNS.

PI_NAMEs: PEREZ, MONICA A (contact)

PROJECT_TERMS: Acoustics;Amyotrophic Lateral Sclerosis;arm;arm function;arm movement;Behavioral;Brain;Caregivers;Caring;Cells;Cervical;Cervical spinal cord injury;Cervical spinal cord structure;Chronic;clinical practice;Community Participation;cooking;Crossover Design;Cutaneous;Data;Diameter;Effectiveness;Employment;exercise training;experience;experimental study;follow-up;Future;General Population;Goals;grasp;Hand;Hand functions;hand rehabilitation;Human;Impairment;improved;Individual;Injury;Intervention;Investigation;kinematics;Knowledge;Lesion;Life;Limb structure;Loudness;Measures;Methodology;Methods;Motor;Motor Cortex;motor disorder;motor impairment;Motor Neurons;Movement;Multiple Sclerosis;Muscle;neuromechanism;Neuronal Plasticity;Neurons;Neurostimulation procedures of spinal cord tissue;novel;novel strategies;Participant;Pathway interactions;Persons;Phase;Physiologic pulse;Physiological;post stroke;Process;Protocols documentation;Quadriplegia;Quality of life;randomized controlled design;Reaction Time;Recovery;Recovery of Function;recruit;rehabilitation strategy;Rehabilitation therapy;Reporting;Research;response;Reticular Formation;Signal Transduction;Spinal;Spinal Cord;Spinal cord injury;spine bone structure;Stimulus;Structure;success;Testing;Time;Training;Training Activity;Transcranial magnetic stimulation;transmission process;Travel;Upper Extremity;Veterans;virtual reality;Work

PROJECT_TITLE: Spinal Cord Stimulation for Functional Recovery in Humans with Tetraplegia

STUDY_SECTION: RRDA

STUDY_SECTION_NAME: Spinal Cord Injury/Disorders & Neuropathic Pain[RRDA]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: DALLAS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Public Health relevance/Narrative Defects in the primary cilia modify progression of cystogenesis in polycystic kidney disease models in mice, but the identity and role of ciliary regulators are unknown. This project addresses several key issues in signaling generated by primary cilium, including mechanisms underlying trafficking of proteins to the ciliary membrane, and will use orthologous mouse and cell culture models to evaluate the role of ciliary trafficking in pathogenesis of polycystic kidney disease. Testing the mechanisms of ciliary trafficking of potential regulators and role of cilium-generated signaling with respect to kidney cystogenesis could potentially provide molecular targets for ameliorating disease progression in humans.

PI_NAMEs: MUKHOPADHYAY, SAIKAT  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acceleration;Address;Adenylate Cyclase;Adolescent;Adult;Affect;Age;Ankyrin Repeat;Automobile Driving;Autosomal Dominant Polycystic Kidney;Binding;Biological;Biosensor;Cell Culture Techniques;Cells;Cilia;Collaborations;Complex;conditional knockout;Coupling;Cultured Cells;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cyst;Data;Defect;Development;Dilatation - action;Disease;disease model;Disease Progression;Embryo;Epithelium;Exclusion;Exhibits;extracellular;Genes;Genetic Epistasis;Growth;GTP-Binding Proteins;Guanosine Triphosphate Phosphohydrolases;Human;in vivo;inhibitor;insight;Kidney;Knock-out;Liquid substance;Membrane;Membrane Proteins;Modeling;Molecular;Molecular Conformation;Molecular Target;mouse model;Mus;mutant;Mutation;Nature;nephrogenesis;new therapeutic target;novel;Output;Pathogenesis;Pathway interactions;PKD1 gene;PKD2 gene;PKD2 protein;polycystic kidney disease 1 protein;Polycystic Kidney Diseases;predictive modeling;prevent;promoter;Protein Family;Protein Subunits;protein transport;Proteins;public health relevance;renal epithelium;Renal function;Renal tubule structure;Reporting;Repression;Research Personnel;response;Role;Signal Pathway;Signal Transduction;synergism;Testing;trafficking;Tubular formation

PROJECT_TITLE: Role of primary cilium-generated signaling in polycystic kidney disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]