NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Methamphetamine;Neurodegenerative;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

PHR: Project Narrative Despite the widespread use of efficacious antiretroviral therapies in controlling peripheral infection and improving life of HIV patients, The prevalence and severity of HIV-1-associated neurocognitive disorders (HAND) are greatly enhanced (~70%) due to concomitant use of drugs of abuse such as cocaine. Dysregulation of dopamine signaling has been implicated as a risk determinant of HAND. Our study will determine a novel, previously uncertain molecular mechanism(s) driving Tat-induced dysfunction of dopamine system by direct interaction with vesicular monoamine transporter, which is associated with Tat-mediated cognitive/behavioral deficits.

PI_NAMEs: ZHAN, CHANG-GUO ;ZHU, JUN  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Acceleration;Acute;AIDS prevention;antiretroviral therapy;Attenuated;attenuation;Automobile Driving;Behavioral;Binding;Binding Sites;Biological;Biological Assay;Brain;Cell Line;Cells;Chemicals;Cocaine;Cognitive;Cognitive deficits;Computer Models;conditioned place preference;Development;Dopamine;dopamine system;dopamine transporter;Doxycycline;Drug abuse;drug of abuse;Drug usage;Exhibits;extracellular;Functional disorder;Gene Expression Profile;genetic approach;Genetic Transcription;Goals;HIV;HIV Infections;HIV Seropositivity;HIV-1;HIV-associated neurocognitive disorder;Homeostasis;Human;Hybrids;Impaired cognition;improved;In Vitro;in vivo;Incidence;Individual;Infection;inhibitor;Investigation;Knock-in;Knock-in Mouse;Life;Link;Mediating;Methamphetamine;methamphetamine abuse;methamphetamine effect;Methamphetamine prevention;methamphetamine user;Molecular;molecular dynamics;mouse model;mutant;Mutation;Nervous System Trauma;neuroAIDS;neuroblastoma cell;Neurocognitive Deficit;neuropsychiatry;novel;Nucleus Accumbens;Patients;PC12 Cells;Periodicity;Peripheral;Persons;pharmacologic;Play;Potassium;Prefrontal Cortex;Presynaptic Terminals;Prevalence;prevent;Proteins;Public Health;Publishing;putamen;Rat Transgene;Rewards;Risk;Role;Scanning;Severities;Signal Transduction;Site-Directed Mutagenesis;Slice;Substance abuse problem;Synaptic Vesicles;Therapeutic;Trans-Activators;Transcription Coactivator;Transgenic Mice;Transgenic Organisms;transmission process;uptake;Validation;Vesicle;vesicular monoamine transporter;vesicular monoamine transporter 2;Viral Proteins;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Effects of HIV-1 Tat protein and methamphetamine on VMAT2-mediated dopamine transmission in the context of neuroHIV and drug abuse

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Patient Safety;Prevention

ORG_CITY: BIRMINGHAM

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PI_NAMEs: LEATH, CHARLES A. (contact)

PROJECT_TERMS: Abbreviations;Achievement;Advanced Malignant Neoplasm;Alabama;anti-cancer research;authority;Basic Science;Biometry;burden of illness;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;cancer therapy;Catchment Area;Clinical;Clinical Data;Clinical Protocols;Clinical Research;Clinical Research Protocols;Clinical Trials;Collection;Communication;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Data;data management;Dedications;Diagnosis;Discipline;Disease;Documentation;Electronics;Ensure;Evaluation;Event;expedited review;Feedback;Foundations;Future;Goals;Human Subject Research;improved;Institutional Review Boards;Intervention;Intervention Trial;Investigational Therapies;investigator-initiated trial;Knowledge;Laboratories;Letters;Malignant Neoplasms;Medicine;meetings;member;Mission;Monitor;neuro-oncology;Oncology;operation;participant safety;Pharmacology;Population;Population Sciences;Prevention;probation;Procedures;Process;programs;protocol development;Protocols documentation;Radiology Specialty;Recommendation;remediation;Research;Research Personnel;Research Priority;Review Committee;Safety;Services;Source;Standardization;survivorship;System;Time;tumor immunology;Universities;virtual;working group;Writing

PROJECT_TITLE: Protocol Review and Monitoring System

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Cost Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: PROJECT NARRITIVE As a D-ARC, the Center for HIV and Research in Mental Health (CHARM) successfully  re-ignited and dramatically grew high-impact meaningfully community-engaged research efforts and infrastructure at the University of Miami, located in a region of the U.S. that is one of the hardest hit geographic areas affected by the HIV/AIDS epidemic. Transitioning to a Full-ARC after successfully meeting D-ARC goals will capitalize on our trajectory, facilitating continued growth of multidisciplinary research addressing HIV-related mental health disparities and the impact of these disparities on the HIV care and prevention continua.

PI_NAMEs: FEASTER, DANIEL J (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;AIDS prevention;Applications Grants;Architecture;Area;Award;Behavioral;biobehavior;Biological Markers;Biometry;Caring;Cities;Clinical Treatment;Clinical Trials Network;Collaborations;Common Data Element;community engaged research;community engagement;community partners;comorbidity;Complement;Complex;Consent;Consultations;cost effectiveness;Cost Effectiveness Analysis;Data;data management;data repository;data warehouse;Databases;design;Development;Disparity;Doctor of Philosophy;Drug abuse;Drug usage;Economic Models;Educational workshop;eHealth;Epidemic;Ethics;Evidence based practice;Extramural Activities;Funding;Geographic Information Systems;Geographic Locations;Geography;Goals;Growth;Haitian;health assessment;health data;health disparity;health economics;health goals;Health Resources;Healthcare Systems;Heterogeneity;HIV;HIV/AIDS;Implant;Individual;Inflammation;Infrastructure;Injectable;innovation;instrument;Interdisciplinary Study;International;intersectionality;Intervention;Language;Libraries;Machine Learning;Maps;Measurement;Measures;meetings;Mental Health;Methodology;Methods;mHealth;minority health disparity;Modality;Modeling;Modernization;Molecular Neurobiology;multilevel analysis;National Institute of Drug Abuse;Nature;Neighborhoods;Outcome;outcome disparities;Population;Prevention;Process;programs;Psychometrics;Psychosocial Assessment and Care;Qualitative Methods;Qualitative Research;relational database;Reproducibility;Research;Research Design;Research Personnel;Research Support;Resource Sharing;Resources;Science;Services;social;social culture;social structure;Spanish;Statistical Data Interpretation;Statistical Methods;Strategic Planning;Stress;Subgroup;Substance abuse problem;success;synergism;Techniques;Technology;therapy development;Training;treatment effect;Triage;Universities;Validity and Reliability;Viral Load result;Visualization;Work

PROJECT_TITLE: The University of Miami AIDS Research Center on Mental Health and HIV/AIDS - Center for HIV & Research in Mental Health (CHARM)Research Core - Methods


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE This study will provide important new insights into how genetic variants in humans influence risk for coronary artery disease (responsible for a quarter of all deaths in the US), which could support the discovery and development of much-needed new classes of therapies. It will also establish a novel, generalizable method that could dramatically accelerate the discovery of biological mechanisms for many other common diseases.

PI_NAMEs: ENGREITZ, JESSE M;GUPTA, RAJAT M (contact)

PROGRAM_OFFICER_NAME: LUO, JAMES

PROJECT_TERMS: Acceleration;Address;Affect;Atherosclerosis;Biological;biological adaptation to stress;Biological Assay;Blood Pressure;blood pressure control;Blood Vessels;Cardiovascular system;causal variant;Cause of Death;Cell Physiology;cell type;Cells;Cellular Assay;Cellular Morphology;Cessation of life;Cholesterol;Chromosome Mapping;Complex;computational pipelines;Computing Methodologies;Coronary Arteriosclerosis;cytokine;Data;data integration;Data Set;Development;Disease;disorder risk;Distal;effective therapy;Endothelial Cells;Endothelin-1;Enhancers;epigenomics;experimental study;Genes;Genetic;Genetic Diseases;Genetic study;Genetic Transcription;genetic variant;genome wide association study;genomic locus;Goals;Guide RNA;Heritability;Human;human disease;Hyperlipidemia;Hypertension;in situ sequencing;Inflammatory;insight;invention;Link;Maps;Measures;Methodology;Methods;Molecular;Morphology;novel;oxidized low density lipoprotein;Paint;Pathway interactions;Phenotype;Physiological;prevent;Process;programs;Rest;Risk;shear stress;Signal Pathway;Stimulus;Technology;Testing;Time;transcriptome;transcriptomics;United States;Untranslated RNA;Variant;Vascular Endothelial Cell;Vasoconstrictor Agents;Work

PROJECT_TITLE: High-throughput cellular genetics to connect noncoding variants to coronary artery disease genes

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative for Other Components Please see Overall Component for Project Narrative. PAR-20-308 Guidelines Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRA systems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components. SF424 Guidelines Overall Component: The "Project Narrative" attachment is required. Other Components: Refer to the specific FOA to determine whether the "Project Narrative" attachment is required for any Other Components. Note: The form may show ‘*’ indicating it is a required field, but it is only required for the Overall Component and the ‘*’ can be ignored for Other Components.

PI_NAMEs: DALE, SANNISHA K. (contact)

PROJECT_TERMS: Acceleration;access disparities;Acquired Immunodeficiency Syndrome;Address;Adherence;Adult;Adverse effects;Advocacy;Affect;AIDS prevention;Automobile Driving;Award;Black race;Caring;Clinic;Collaborations;Communities;community advisory board;community engaged intervention;community engaged research;community engagement;community organizations;community partners;comorbidity;Consent;Consultations;cultural competence;data quality;Databases;design;Development;Disadvantaged;Disparity;Doctor of Philosophy;Education;Ensure;Environment;Epidemic;Equity;Ethics;ethnic minority population;Ethnic Origin;Faculty;Federally Qualified Health Center;Florida;Foundations;Funding;gender minority group;Grant;Growth;Guidelines;Health;health disparity;health inequalities;HIV;HIV disparities;HIV/AIDS;Home;human subject;Human Subject Research;Incidence;Informed Consent;innovation;insight;Intervention;Knowledge;Latina;Latino;Latinx;Lesbian Gay Bisexual Transgender Queer;life span;Linguistics;marginalized community;marginalized population;Measures;Medical;Medicine;member;Mental disorders;Mental Health;Mental Health Services;minority communities;Minority Groups;minority health disparity;Mission;Monitor;multidisciplinary;Outcome;Participant;Persons;Population;Populations at Risk;Positioning Attribute;Predisposition;Prevention;Process;Psychiatry;Psychology;Psychosocial Assessment and Care;Public Health;Race;racial minority population;racial population;racism;Research;Research Activity;Research Personnel;Research Priority;Research Proposals;Risk;risk minimization;Running;Safety;Sampling;Series;Services;Sexual and Gender Minorities;sexual minority group;social culture;social media;social stigma;sound;structural determinants;substance use;System;theories;therapy development;tool;Translating;trend;Trust;Universities;uptake;Voice;Work

PROJECT_TITLE: The University of Miami AIDS Research Center on Mental Health and HIV/AIDS - Center for HIV & Research in Mental Health (CHARM)Research Core & MHD-CE


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

ORG_STATE: NY

PHR: Narrative Addictive psychostimulants such as amphetamine act in the striatum at the synapses of dopamine neurons, particularly those utilizing glutamate as a cotransmitter. Elucidating how amphetamine affects these synapses will provide new insight into addiction mechanisms and potential treatments.

PI_NAMEs: RAYPORT, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Acute;addiction;Affect;Amphetamines;Anterior;Attenuated;attenuation;Automobile Driving;Behavior;Behavioral;Cell membrane;cholinergic;Complex;Corpus striatum structure;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;Dopamine Receptor;dopaminergic neuron;Dorsal;Dose;drug action;Drug Addiction;gamma-Aminobutyric Acid;Genetic Marker Expression;Glutamates;Heterogeneity;Hour;insight;Interneurons;Lateral;Maps;Medial;Mediating;Membrane Transport Proteins;Metabotropic Glutamate Receptors;Neurons;neurotransmission;novel;Nucleus Accumbens;Pharmaceutical Preparations;Pharmacotherapy;postsynaptic;presynaptic;psychostimulant;putamen;receptor;Site;Synapses;Synaptic Transmission;therapeutic target;Time;transmission process;uptake

PROJECT_TITLE: Synaptic Actions of Amphetamine in the Striatum

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-R(02)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Bacterial virulence often relies on the secretion of effectors across the cell envelope, which mediate numerous processes including biofilm formation, nutrient acquisition, and immune evasion. Herein, we propose to characterize a putative variation of the type VIII secretion system (T8SS) that is required for surface-association of polysaccharides in the diverse, clinically-relevant Gram-negative pathogens Acinetobacter baumannii and Pseudomonas aeruginosa, thereby facilitating biofilm formation. As this uncharacterized T8SS variant is widespread in Gram-negative bacteria, findings from this research may have broad-reaching implications on our understanding of the biology and virulence of numerous pathogens.

PI_NAMEs: FELDMAN, MARIO  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acinetobacter;Acinetobacter baumannii;Amyloid fibers;Attenuated;attenuation;Bacteria;Binding;Bioinformatics;Biology;Carrier Proteins;catheter associated UTI;Caulobacter crescentus;cell envelope;Cell Fractionation;Cell surface;Cells;clinically relevant;Co-Immunoprecipitations;Complex;Congo Red;Cryoelectron Microscopy;Data;Escherichia coli;Genes;Gram-Negative Bacteria;Homologous Gene;Hypothetical Protein;Immune Evasion;Infection;Mass Spectrum Analysis;Mediating;Membrane;Microbial Biofilms;Modeling;Molecular;Mus;mutant;Mutation;novel;Nutrient;Operon;pathogen;Pathogenesis;Phenotype;Plasmids;Pneumonia;Polysaccharides;Process;Production;Protein Secretion;Proteins;Proteome;Pseudomonas aeruginosa;Public Health;Repression;Research;Role;Salmonella;scaffold;Structure;Surface;System;Testing;Variant;Virulence

PROJECT_TITLE: A Novel Type VIII Secretion System in Gram-negative Bacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-D(02)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: IOWA CITY

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: This application requests continuation of funding for a successful and well-established training program rebranded five years ago as the Iowa Neuroscience Specialty Program In Research Education (INSPIRE). INSPIRE integrates training in Translational Neuroscience with an emphasis on a lifespan trajectory perspective of neuropsychiatric mechanisms, with the ultimate goal of advancing research in the understanding and treatment of mental illnesses.

PI_NAMEs: STEVENS, HANNA E (contact);WEMMIE, JOHN A

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TITLE: The Iowa Neuroscience Specialty Program in Research Education (INSPIRE)


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention

PI_NAMEs: HARKNESS, AUDREY  (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Administrative Supplement;Adopted;Adoption;Award;Behavior Therapy;Black race;career;Clinical;clinical practice;Communities;community collaboration;community engaged research;Community Practice;Consent;Consultations;County;Databases;Development;Disparity;Doctor of Philosophy;early-career faculty;Educational workshop;Effectiveness;efficacy research;Elements;Ensure;Epidemic;epidemic preparedness;Equity;Ethnic Origin;evidence base;Evidence based intervention;experience;Faculty;Florida;Funding;Future;Goals;Grant;Growth;Guidelines;Health;health care delivery;health disparity;HIV;HIV disparities;HIV/AIDS;implementation efforts;implementation research;implementation science;implementation strategy;implementation trial;improved;Individual;Infrastructure;interest;International;Intervention;Latino;Link;member;Mental Health;Mentors;Methodology;minority investigator;Mission;Pathway interactions;Population;Process;programs;Publishing;Race;Research;Research Personnel;Research Support;Research Training;Resources;Rural;scale up;Scientist;Services;sexual identity;skills;symposium;System;Testing;Training;Training Programs;Translations;Trust;Underrepresented Minority;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: The University of Miami AIDS Research Center on Mental Health and HIV/AIDS - Center for HIV & Research in Mental Health (CHARM)Research Core - EIS


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Targeting unique features of cancer cells is a preferred therapeutic strategy to inhibit metastatic progression while limiting off-target effects in normal cells. We are testing new ideas on how the unique feature of increased intracellular pH (pHi) in cancers compared with normal adult cells can be targeted to limit cancer metabolism and tumorigenesis. Our expected outcomes are substantial new views on the importance of increased pHi in cancer progression that will impact new therapeutic strategies to limit progression of cancers from different tissue origins and genetic backgrounds.

PI_NAMEs: BARBER, DIANE L (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affinity;anti-cancer research;Binding;Binding Proteins;Biophysics;Biopsy;Biosensor;cancer cell;cell behavior;Cell membrane;Cells;Cellular biology;Charge;ChIP-seq;Clinical;colon cancer patients;Colorectal Cancer;Colorectal Neoplasms;Data;deprotonation;design;Disease Progression;Dissociation;DNA;DNA Binding;DNA Binding Domain;DNA-Binding Proteins;Drosophila genus;Electrostatics;Epithelium;Evolution;Family;Fluorescence Anisotropy;FOXC2 gene;Funding;Gene Expression;Gene Expression Regulation;Genes;Genetic;genome-wide;Heterogeneity;Histidine;Human;Hydrogen Bonding;Immunologic Surveillance;in vivo;in vivo imaging;insight;Invaded;Ligands;Malignant Neoplasms;Mediating;Metabolic;Molecular;mouse model;neoplastic cell;Normal Cell;novel therapeutic intervention;Nuclear;Nucleic Acids;Nucleotides;Organoids;Outcome;Pathway interactions;Phenotype;Phospholipids;Population;Post-Translational Protein Processing;preference;prognostic value;Property;Proteins;protonation;Recombinant DNA;Reporter;Reporting;Role;serial imaging;single-cell RNA sequencing;Somatic Mutation;SOX4 gene;Specificity;spheroids;stem cell differentiation;stem cells;Testing;Therapeutic;Time;Tissues;Titrations;transcription factor;transcriptomics;tumor;tumor heterogeneity;tumor metabolism;tumor progression;Tumor Suppressor Proteins;tumorigenesis;Work

PROJECT_TITLE: Roles for Intracellular pH Dynamics in Cancer

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Public Relevance Statement African American population is projected to increase up to 18% by 2060 in the US and as the population increases, the deleterious effects of maternal hyperglycemia will also. Sleep disparities exist in African American pregnant women and can lead to disparities in maternal hyperglycemia and related maternal and fetal complications of pregnancy. This innovative study using individually tailored, culturally adapted intervention has the potential to advance science, reduce hyperglycemia, improve glucose metabolism, and improve maternal- fetal well-being by demonstrating the effectiveness of sleep BETTER intervention.

PI_NAMEs: IZCI BALSERAK, BILGAY  (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Address;Adverse effects;Affect;African American;African American population;African American Women;Aftercare;aged;American;Appetite Regulation;Area Under Curve;attentional control;Beds;Behavior;Behavioral;behavioral sleep intervention;Birth;Birth trauma;Caffeine;Cardiovascular Diseases;Cesarean section;Child;Clinic;Cognitive;Cognitive Therapy;Communities;cost;cost effective;culturally appropriate intervention;Data;Disparity;Eating;Economics;Education;Educational Curriculum;Educational Intervention;Effectiveness;efficacy evaluation;Enrollment;ethnic disparity;Exercise;fasting glucose;fetal;fitbit;food security;Future;General Population;Gestational Diabetes;Glucose;glucose metabolism;glucose tolerance;glycemic control;Goals;Health;health disparity;healthy lifestyle;hospital care;Household;Hyperglycemia;improve minority health;improved;improvement on sleep;Individual;innovation;instrument;insulin sensitivity;Interdisciplinary Study;Intervention;Intervention Studies;Knowledge;Life Cycle Stages;Life Style;Light;Link;Low income;Mainstreaming;maternal hyperglycemia;Measures;Medical Care Costs;Mental Depression;Meta-Analysis;Metabolic;Metabolism;Methods;Mission;modifiable behavior;modifiable risk;Mothers;motivational enhancement therapy;National Institute on Minority Health and Health Disparities;next generation;Noise;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Nonpharmacologic Therapy;novel;Nulliparity;Obesity;obesity risk;offspring;Outcome;Overweight;Participant;Patient Self-Report;Personal Satisfaction;Pilot Projects;Polysomnography;poor sleep;Population;post intervention;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnant Women;prenatal;Prenatal care;Preparation;primary outcome;Psychosocial Stress;Race;racial discrimination;racial disparity;Randomized;Randomized, Controlled Trials;Recurrence;Reduce health disparities;Research;Risk;Risk Factors;Role;Science;Sleep;Sleep disturbances;sleep health;sleep quality;Social status;Social support;Stress;Telephone;Testing;Thinking;Time;tool;White Women;Woman;Work

PROJECT_TITLE: A Randomized Control Trial to improve metabolic outcomes in African American pregnant women

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: IRVINE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: UCI ADRC Overall Project Narrative The U.S. is in the midst of a crisis on Alzheimer's disease (AD) and Orange County California is in the epicenter as there are more people with AD living here than in 26 other states. The University of California, Irvine Alzheimer's Disease Research Center (UCI ADRC) is strategically located to have a major positive impact as we identify, quantify, and validate factors that influence the risk of AD across the lifespan. The UCI ADRC brings energetic and innovative multi-dimensional and multi-disciplinary approaches toward solving this insidious disease, contributes to several national collaborative efforts, and provides key resources to the research community, including studying special populations impacted by the disease, such as underrepresented ethnic groups, adults with Down syndrome, and the oldest-old.

PI_NAMEs: LAFERLA, FRANK M (contact)

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: Address;Adult;Advisory Committees;Age;Aged, 80 and over;aging population;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapy;Asian Americans;Autopsy;Basic Science;Biological Markers;biomarker development;Blood;Brain Diseases;Brain Pathology;brain tissue;California;cell bank;Clinical;Clinical Research;Clinical Sciences;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;cohort;Collaborations;Communities;Complex;Computer software;Consent;County;Data;Data Analyses;data management;Data Set;Dementia;Development;Diagnosis;diagnostic criteria;Dimensions;Disease;Disparity;Down's Syndrome;Education;education research;effective therapy;Ensure;Epidemic;Ethics;Ethnic Population;Etiology;Faculty;Genetic;Goals;Image;Impaired cognition;in vivo;Individual;induced pluripotent stem cell;Infrastructure;innovation;insight;interdisciplinary approach;interdisciplinary collaboration;International;Knowledge;Leadership;life span;meetings;mild cognitive impairment;Mission;Modernization;Molecular;multidisciplinary;Nature;neuroimaging;neuropathology;next generation;novel;novel diagnostics;Older Population;open source;Oranges;Outcome;Participant;participant retention;Pathogenesis;Pathologic;Pathway interactions;Patients;Persons;Play;Populations at Risk;Predisposition;prevent;prodromal Alzheimer's disease;Productivity;Protocols documentation;Recording of previous events;recruit;recruitment science;Registries;Research;Research Methodology;Research Personnel;resilience;Resources;Role;Scholarship;Science;Scientist;Societies;Special Population;Stains;stem cell biology;success;Technology;Training;Translational Research;Universities;Vision;Work

PROJECT_TITLE: The Alzheimer's Disease Research Center at the University of California, Irvine


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Achievement;Action Research;Adult;Advisory Committees;Age-associated memory impairment;Alzheimer's Disease;Award;Basic Science;Biological Markers;Brain Pathology;California;Clinical;Clinical Research;cohort;Collaborations;Communities;Consent;data management;Dementia;Development;Discipline;Down's Syndrome;Ecosystem;Education;Education and Outreach;education research;Ensure;Faculty;Fostering;Goals;Head;healthy aging;Impaired cognition;induced pluripotent stem cell;innovation;Leadership;life span;meetings;member;Mission;Modification;Neurobiology;Neurodegenerative Disorders;neuropathology;Neurosciences;next generation;novel;Occupational activity of managing finances;Office of Administrative Management;outreach;outreach program;Patient Recruitments;Play;Population Heterogeneity;Prize;Productivity;programs;Recommendation;Recording of previous events;recruit;Registries;Research;Research Personnel;Research Project Grants;Resources;Risk;Role;Science;Scientist;Special Population;success;Suggestion;Textbooks;Time;Training;Training and Education;Translational Research;Universities

PROJECT_TITLE: Core A-Administrative Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Large-scale hurricanes could have a devastating effect on vulnerable people with complex chronic conditions. In this study, we examine the long-term impact of Hurricane Maria on migration and mortality and morbidity of patients with kidney failure in Puerto Rico and the strategies providers adopted to mitigate poor health outcomes.

PI_NAMEs: RIVERA-HERNANDEZ, MARICRUZ  (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Adopted;Adverse event;Area;Caring;Cessation of life;Chronically Ill;Clinic;Clinical;Complex;complex chronic conditions;Continuity of Patient Care;Data;Decision Making;Dialysis patients;Dialysis procedure;Disasters;drinking water;Economically Deprived Population;Electricity;Emergency department visit;experience;Goals;health care availability;health care delivery;health care disparity;health disparity populations;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;Hemodialysis;Hospitalization;hospitalization rates;Hospitals;Hurricane;improved;Information Systems;Infrastructure;insight;interest;Interview;Island;Kidney;Kidney Failure;Long-Term Effects;Longitudinal Studies;Longitudinal trends;medical specialties;Migrant;migration;Modernization;Morbidity - disease rate;mortality;mortality risk;National Institute on Minority Health and Health Disparities;Natural Disasters;Nonmigrant;novel;older adult;Out-Migrations;Outcome;outcome disparities;Outpatients;Patient-Focused Outcomes;Patients;Pattern;Persons;Policies;poor health outcome;Population;prevent;Provider;Public Health;Puerto Rican;Puerto Rico;Readiness;Recording of previous events;Research;Research Methodology;research study;response;Role;Services;social;socioeconomic disadvantage;socioeconomics;Specialist;Telephone;Travel;vulnerable community;Vulnerable Populations;Work

PROJECT_TITLE: Long-Term Effects of Hurricane Maria on Healthcare Delivery, Migration and Mortality Among People with Kidney Failure in Puerto Rico

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: SULTZER, DAVID  (contact)

PROJECT_TERMS: Agreement;Alzheimer associated neurodegeneration;Alzheimer's Disease;Amyloid;Ancillary Study;Asian;Asian Americans;Autopsy;Biochemical;Biological Markers;Blood;Blood Vessels;Brain;California;Cardiovascular system;Cell Line;Cerebrospinal Fluid;Cessation of life;Chinese American;Clinical;Clinical assessments;Clinical Data;Clinical Research;clinical trial participant;Clinical Trials;Cognitive;cognitive testing;cohort;Collaborations;Collection;Consent;Data;data management;Data Set;demented;Dementia;Deposition;diagnostic criteria;Disease;disorder risk;Ecosystem;Education;education research;Enrollment;Ethnic Origin;Female;Fibroblasts;follow-up;Funding;Generations;Genetic;genetic analysis;Hispanic;Home;Image;Impaired cognition;improved;inclusion criteria;Individual;induced pluripotent stem cell;innovation;Investigation;life span;Link;Longitudinal cohort;Magnetic Resonance Imaging;Methodology;mild cognitive impairment;Minority;Mission;Molecular;Neurocognitive;neuroimaging marker;Neurologic;next generation;novel;outreach;Participant;participant enrollment;Peripheral Blood Mononuclear Cell;Persons;Population;Positron-Emission Tomography;pre-clinical;Procedures;programs;Punch Biopsy;Questionnaires;Race;Randomized;recruit;Registries;Research;Research Personnel;Research Project Grants;Research Support;Resolution;Resources;retention rate;Risk;Role;Sampling;Skin;Spinal Puncture;stem cells;Symptoms;System;tau Proteins;Telephone;Telephone Interviews;tissue biomarkers;Tissue Donations;Tissues;Training;Training and Education;Translational Research;Universities

PROJECT_TITLE: Core B-Clinical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: GILLEN, DANIEL L (contact)

PROJECT_TERMS: Alzheimer's Disease;Architecture;Big Data;Biological Markers;biomarker discovery;biomarker validation;California;Clinical;Clinical Data;Clinical Trials Design;Collaborations;Collection;Communication;Communities;complex data;Conceptions;Consultations;Data;Data Collection;data dissemination;data management;Data Set;data streams;Database Management Systems;Databases;design;Development;Digital biomarker;Education;Electrocardiogram;Ensure;Event;Faculty;flexibility;Funding;Goals;graph database;Heart Rate;heterogenous data;high dimensionality;Human Resources;Image;imaging biomarker;improved;informal learning;innovation;life span;machine learning prediction;Maintenance;member;Methodology;Methods;Mission;Modeling;next generation;novel;Observational Study;Pathologic;Phase;predictive modeling;Process;programs;Protocols documentation;Reporting;Reproducibility;Research;research and development;Research Personnel;Research Project Grants;research study;Risk;Sampling Biases;Secure;semiparametric;smart device;Standardization;statistical and machine learning;Statistical Methods;statistics;Techniques;Testing;Training;Training and Education;Universities;Validation

PROJECT_TITLE: Core C-Data Management & Statistics Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: MONUKI, EDWIN S (contact)

PROJECT_TERMS: Adherence;adjudication;Age;Aliquot;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;Artificial Intelligence;Astrocytes;Autopsy;Award;biobank;Biological Markers;Biology;Blood specimen;Brain;brain tissue;California;Catalogs;Cd68;cell type;Cells;Clinical;clinical conference;Clinical Data;clinical trial participant;cohort;Collaborations;Collection;data management;Data Set;Deposition;Diagnosis;Diagnostic;digital;Disease;Doctor of Philosophy;Down's Syndrome;Education;education research;Ensure;Equipment and supply inventories;Faculty;Family;Fibroblasts;Functional disorder;Funding;Generations;Genetic Diseases;genome wide association study;glial activation;Glial Fibrillary Acidic Protein;Goals;Grant;Guidelines;Harvest;Head;Health system;high risk;Hour;Individual;induced pluripotent stem cell;Infrastructure;innovation;Institution;integration site;International;life span;Light;Link;Magnetic Resonance Imaging;member;Mentorship;Methods;Microglia;Microscopy;Minority;mixed dementia;Morphology;National Institute on Alcohol Abuse and Alcoholism;Neurons;neuropathology;next generation;nonalzheimer dementia;novel;operation;outreach;Participant;Pathology;Performance;Practice Guidelines;Predisposition;Process;professor;Protocols documentation;Publications;recruit;Reporting;Research;Research Personnel;Resources;Rotation;Sampling;Services;Site;Skin;Special Population;Stains;Standardization;System;tau Proteins;Training and Education;Universities;Visit;whole slide imaging;Work

PROJECT_TITLE: Core D-Neuropathology Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: GRILL, JOSHUA  (contact)

PROJECT_TERMS: Acceleration;Advocacy;Affect;age related;Alzheimer's Disease;Alzheimer's disease diagnosis;Asian Americans;Awareness;brain health;California;Caregivers;Clinical;clinical care;Clinical Data;Clinical Management;Clinical Research;Clinical Trials;cohort;Collaborations;Communities;community engagement;Community Health Education;Community Healthcare;Community Outreach;Consent;cost;County;Data;data management;Data Set;Diagnosis;Ecosystem;Education;Education and Outreach;education research;Effectiveness;effectiveness evaluation;Electronics;Ensure;Ethics;Ethnic Origin;Faculty;Family;Goals;Health Professional;hispanic community;human old age (65+);improved;Individual;innovation;Intervention;knowledge base;Laboratories;Leadership;Life Style;lifestyle data;Link;Location;Longitudinal Studies;Methods;multimodality;next generation;novel;Oranges;outreach;Participant;participant retention;Patient Recruitments;Patients;Persons;Physicians;Population;Positioning Attribute;Prevalence;prevent;Printing;Procedures;public education;Qualifying;Race;Recommendation;recruit;recruitment science;Registries;Research;Research Design;Research Personnel;Resources;retention rate;Risk Factors;Role;Sampling;social media;tool;Touch sensation;Training and Education;Translating;treatment guidelines;Trust;United States;Universities;Update;web site;willingness;Work

PROJECT_TITLE: Core E-Outreach, Recruitment & Engagement Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: BLURTON-JONES, MATHEW MARK (contact)

PROJECT_TERMS: Aged, 80 and over;Aging;Alzheimer's Disease;Alzheimer's disease risk;Award;Biological;Biological Markers;brain cell;California;Cell Differentiation process;Cell Line;Cell Physiology;Cell Reprogramming;Cells;Cellular biology;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Cognitive;cohort;Collaborations;Communities;Consent;Controlled Study;cost;Data;data management;Data Set;Dementia;Development;Down's Syndrome;Early Onset Alzheimer Disease;education research;Ethics;Exhibits;Fibroblasts;Foundations;Funding;gene correction;Generations;Genes;Genetic;Genetic Diseases;Genetic Risk;Genetic study;Genome engineering;genome wide association study;Genotype;Goals;Grant;Heterozygote;Human;Impairment;induced pluripotent stem cell;innovation;Late Onset Alzheimer Disease;life span;Link;mosaic;mRNA Expression;Mutation;Neurochip;neuropathology;next generation;novel therapeutic intervention;outreach;Participant;Pathologic;Pathology;Peripheral Blood Mononuclear Cell;PLCG2 gene;polygenic risk score;Population;Postdoctoral Fellow;protein expression;Quantitative Trait Loci;recruit;repository;Research;Research Personnel;resilience;Resources;Risk;Risk Factors;risk variant;Sampling;Single Nucleotide Polymorphism;Skin;Special Population;stem cell growth;Stem Cell Research;Students;System;tau Proteins;Teacher Professional Development;Training;Training and Education;TREM2 gene;United States;United States National Institutes of Health;Universities;Untranslated RNA;Variant;Work

PROJECT_TITLE: Core F: Induced Pluripotent Stem Cell Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: STARK, CRAIG E (contact)

PROJECT_TERMS: Abbreviations;Address;Adult;Affect;Alzheimer's Disease;American;Amyloid beta-42;Amyloid beta-Protein;analysis pipeline;Area;Autopsy;Behavior;Behavioral;Biological Assay;Biological Markers;biomarker development;Blood;Blood Tests;Brain;Brain imaging;Brain scan;California;career;Cerebrospinal Fluid;Clinical;clinical conference;clinical diagnosis;Cognitive;cognitive testing;cohort;Communities;cost;Data;Data Collection;data management;Data Set;data sharing;data structure;Dementia;density;Development;Diffusion Magnetic Resonance Imaging;Disease;Down's Syndrome;Early Diagnosis;Educational process of instructing;effectiveness evaluation;Ensure;Etiology;Faculty;Fiber;Foundations;Future;Generations;Goals;gray matter;Hippocampus;Histologic;Image;induced pluripotent stem cell;innovation;International;Knowledge;life span;Link;Liquid substance;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;member;Memory;Mentorship;Mission;Modernization;Monitor;Motor;MRI Scans;Narration;Neurites;neuroimaging;neuroinflammation;neuropathology;next generation;novel;novel marker;outreach;Participant;Pattern;Positron-Emission Tomography;prevent;Process;Progressive Disease;Proteins;Protocols documentation;Quality of life;Reporting;Research;Research Personnel;Resolution;Risk;Sampling;Scanning;Science;Speech;Structure;Symptoms;System;tau Proteins;tau-1;Techniques;Training;Training and Education;Treatment Effectiveness;Universities;Update;white matter;Work

PROJECT_TITLE: Core G: Biomarker Core


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW ORLEANS

ORG_DEPT: BIOLOGY

ORG_NAME: DILLARD UNIVERSITY

ORG_STATE: LA

PHR: PROJECT NARRATIVE Dillard University proposes to initiate new academic development activities that will strengthen and enhance our existing research and academic support activities for underrepresented (UR) students. As a competitive liberal arts HBCU, Dillard’s U-RISE program will implement an interdisciplinary early inquiry-based group research program and a collaborative intervention and retention program to increase overall UR student applications to research graduate degree programs, and promote their entry into biomedical/ behavioral careers. By improving on our current graduate school application rate, Dillard will have a significant impact on UR students who plan to attend graduate school and finish a research doctoral degree.

PI_NAMEs: BROADWAY, RUBY  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Academic support;African American;Area;Arts;Behavioral;Behavioral Sciences;Binding;Biomedical Research;career;college;Communities;community engagement;curriculum enhancement;Dedications;Degree program;Educational Curriculum;Educational process of instructing;Educational workshop;experience;Faculty;Foundations;Graduate Degree;graduate school;Health Sciences;Healthcare;Hurricane;improved;Institution;Internships;Intervention;Knowledge;Louisiana;Outcome;Population;Preparation;programs;Reproducibility;Research;Research Support;Research Training;restoration;Schools;Science;science teacher;Scientist;skills;square foot;student participation;Students;Talents;Training;undergraduate research;undergraduate student;underrepresented minority student;Universities;Vocational Guidance

PROJECT_TITLE: U-RISE AT DILLARD UNIVERSITY

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Narrative The basis of this proposal is to elucidate the mechanism(s) of ultrasound scattering in biological tissues by systematically studying structure functions using solid tumors from animal models and hepatocellular carcinoma in adult human subjects, and thereby improve the accuracy of Quantitative Ultrasound (QUS, the quantification of tissue microstructure) techniques in noninvasive tumor detection and classification. The successful completion of this study will have significant impact at both the basic and clinical science levels to improve the accuracy of tumor diagnosis.

PI_NAMEs: O'BRIEN, WILLIAM D. (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Adult;Animal Model;Animals;Apoptotic;Architecture;Basic Science;Biological;Biopsy;Blood;Breast;Breast Cancer Treatment;Cancerous;Cell Nucleus;Cells;Cirrhosis;Classification;Clinical;Clinical Sciences;clinically significant;Collection;Contrast Media;Data;design;Detection;Development;Diagnostic;Diagnostic tests;diagnostic value;Disease;disease diagnosis;Event;Eye;Fatty acid glycerol esters;Fatty Liver;Frequencies;General Population;Goals;Heart;Hepatic;Hepatocyte;Histology;Human;human subject;Image;imaging biomarker;improved;in vivo;in vivo Model;Individual;innovation;Investigation;Kidney;Literature;Liver;lymph nodes;model development;Modeling;Monitor;Mus;non-alcoholic fatty liver disease;Non-Invasive Detection;Organ;Outcome;Parameter Estimation;Participant;Patients;Pattern;Positioning Attribute;Premature Birth;Primary carcinoma of the liver cells;Process;programs;Property;Prostate;quantitative ultrasound;Rattus;Research;Signal Transduction;Solid Neoplasm;Spatial Distribution;Statistical Mechanics;Structure;success;Techniques;Technology;Testing;Theoretical model;three dimensional structure;Tissues;translational study;tumor;tumor diagnosis;Ultrasonics;ultrasound;Validation

PROJECT_TITLE: Tumor Detection and Classification using QUS Technology's Structure Function

STUDY_SECTION: BMIT

STUDY_SECTION_NAME: Biomedical Imaging Technology A Study Section[BMIT-A]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences

PI_NAMEs: LOTT, IRA T. (contact)

PROJECT_TERMS: 18 year old;Age;Age Years;Alzheimer's Disease;Alzheimer's disease risk;Amyloid;Amyloid Beta A4 Precursor Protein;Attitude;Biological Markers;Birth;Blood specimen;Brain;California;Caspase;Chromosome 21;Clinical;clinical outcome measures;Clinical Trials;cohort;Collaborations;Consensus;Data Set;data sharing;Dementia;dementia risk;Dependence;Development;Disease;Down's Syndrome;education research;Enrollment;Event;experience;Faculty;Family;feasibility testing;Goals;Individual;innovation;insight;instrument;Intellectual functioning disability;interest;Internet;life span;Magnetic Resonance Imaging;Mission;Neurologic;Neurons;neuropathology;Neuropsychological Tests;next generation;Outcome;Outcome Measure;Oxidative Stress;Participant;Pathogenesis;Persons;Population;Postdoctoral Fellow;Precipitating Factors;Prevalence;Protocols documentation;Questionnaires;Research;Research Personnel;Resources;Risk;Risk Factors;Sampling;Scientist;Site;Special Population;Standardization;Structure;student training;Symptoms;tool;Training;Universities;white matter

PROJECT_TITLE: Core H: Down Syndrome Cohort


NIH_SPENDING_CATS: Human Fetal Tissue;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Women's Health Research

ORG_CITY: SCOTTSDALE

ORG_NAME: VITALANT

ORG_STATE: AZ

PHR: Project Narrative: This proposal examines the role of the human chorion as an active site of blood cell production. The development of macrophages from hematopoietic stem cells in the chorion and their role in providing immunity will be investigated. Results from this study will provide insight into conditions such as chronic chorioamnionitis that threaten pregnancy and may lead to fetal demise.

PI_NAMEs: MUENCH, MARCUS O (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Active Sites;Activities of Daily Living;Address;amnion;Anti-Inflammatory Agents;Biological Assay;Biology;Blood Cells;California;CD34 gene;Cell Culture Techniques;Cell Line;Cell Separation;cell type;Cells;Cerebral Palsy;Chorion;Chronic;Collaborations;cytokine;cytotrophoblast;Data;Decidua;Development;Embryo;embryo tissue;embryo/fetus;Endometrium;experimental study;fetal;Fetal Membranes;Fetus;First Pregnancy Trimester;first responder;Flow Cytometry;Fostering;Gene Expression;Gestational Age;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;hematopoietic tissue;Human;Human Development;Immune;Immune system;Immunity;Immunodeficient Mouse;Immunologics;immunoregulation;In Situ;In Vitro;in vitro Assay;Infection;Infection prevention;inflammatory milieu;insight;intraamniotic infection;Invaded;Laboratories;Low Birth Weight Infant;Lymphocyte;Macrophage;maternal immune system;Maternal-Fetal Exchange;mesenchymal stromal cell;microorganism;Modeling;monocyte;Mothers;Myelogenous;Myelopoiesis;Neonatal Mortality;Pathologic;Phenotype;Placenta;Play;Population;Pregnancy;Premature Birth;prenatal;prevent;Production;progenitor;Proliferating;protein expression;Regulation;Reporting;Research Institute;Role;San Francisco;Sentinel;Site;source localization;Spleen;stem cell population;Supporting Cell;Surface;T cell regulation;T-Cell Activation;T-Lymphocyte;Testing;Tissues;transplant model;Transplantation;trophoblast stem cell;Universities;Villus;ward;Work

PROJECT_TITLE: Hematopoietic and Immune Development in the Human Chorion

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: CORRADA, MARIA  (contact)

PROJECT_TERMS: Age Years;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Asian Americans;Autopsy;Biological Markers;Brain;Brain imaging;brain magnetic resonance imaging;California;career;Clinical;cohort;Collaborations;Collection;Complement;Consent;Data;data management;data resource;Data Set;Dedications;Dementia;Ecosystem;Education;education research;Enrollment;Ensure;Environment;Ethnic Origin;Exclusion;Fatigue;Genetic;Goals;hearing impairment;Hispanic Populations;Image;imaging study;Impaired cognition;improved;Individual;innovation;Investigation;life span;Longevity;Longitudinal Studies;mortality;multimodal data;neuroimaging;neuropathology;next generation;novel;Older Population;outreach;Participant;Pathologic;patient engagement;Persons;Population;Populations at Risk;Procedures;recruit;Research;Research Personnel;resilience;Resolution;Resource Sharing;Resources;Risk;Role;Special Population;Testing;Training and Education;Universities;Visual impairment;Work

PROJECT_TITLE: Core I: 90+ Cohort


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE We found that targeting the oncogenic KRAS-MAPK pathway in pancreatic cancer cells leads to marked induction of TNF secretion, which drives both death and survival including autophagy. Selective inhibition of MK2, which controls the survival signaling, aggravates TNF-mediated tumor cell death. On this basis, we will investigate the mechanisms by which MK2 signaling controls cell survival in cancer cells and shapes the surrounding fibroblasts and immune cells, with the overarching goal of developing novel therapeutic strategies that can be advanced into the clinic.

PI_NAMEs: LIM, KIAN H (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: 3-Dimensional;antitumor effect;Autoimmune Diseases;Autophagocytosis;Bioinformatics;Biological Assay;Biology;Biometry;Biotin;cancer cell;CD8-Positive T-Lymphocytes;Cell Compartmentation;Cell Death;Cell Death Induction;Cell Survival;cell type;Cells;Cessation of life;checkpoint therapy;chemotherapy;Clinic;Clinical;clinical efficacy;Clinical Trials;Coculture Techniques;Collaborations;cost effective;cytokine;Cytolysis;Data;design;Development;effective therapy;Elements;Ensure;Exposure to;factor A;Fibroblasts;Foundations;Genes;Genetic;Genetically Engineered Mouse;Genotoxic Stress;Goals;Hydroxychloroquine;Immune;Immunocompetent;Immunologics;Immunotherapeutic agent;Immunotherapy;improved;inhibitor;Label;Malignant neoplasm of pancreas;Malignant Neoplasms;MAPKAPK2 gene;Mediating;MEKs;Mitogen-Activated Protein Kinase Inhibitor;Mitogen-Activated Protein Kinases;Modeling;Modernization;mouse model;Mus;Mutation;Myeloid Cells;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;Oncogenic;Oncology;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathology;Pathway interactions;patient derived xenograft model;Patients;Pharmacologic Substance;Phenotype;Phosphorylation;PIK3CG gene;preclinical efficacy;preclinical trial;Principal Investigator;Process;Production;programs;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;Regimen;Research Personnel;response;Role;Safety;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;Solid;spheroids;Structure;success;System;T-Lymphocyte;Techniques;Testing;Therapeutic Effect;TNF gene;translational impact;translational potential;treatment response;tumor immunology;tumor microenvironment;Tumor-associated macrophages;tumorigenic;Work

PROJECT_TITLE: Harnessing TNFa Signaling To Improve Therapeutic Response In Pancreatic Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: HEAD, ELIZABETH  (contact)

PROJECT_TERMS: Acceleration;Alzheimer's Disease;Alzheimer's disease related dementia;Basic Science;bench to bedside;Biology;Biomedical Engineering;Biometry;California;career life balance;Clinical;Clinical Trials;Cognition;cohort;Collaborations;Communities;Data Science;Dedications;Dementia;Development;Discipline;Disease;disease model;Down's Syndrome;Ecosystem;Education;education research;Educational Curriculum;Educational workshop;Ensure;Epidemiology;Evaluation;experience;Exposure to;Faculty;Fellowship Program;Foundations;Grant;Growth;Home;Human Subject Research;Immersion;improved;innovation;interdisciplinary approach;International;Knowledge;Lead;Machine Learning;meetings;member;Mentors;Mentorship;Modality;multidisciplinary;Nerve Degeneration;Neurobiology;neuroimaging;neuropathology;Outcome Measure;Positioning Attribute;prevent;Process;Productivity;programs;Recommendation;recruit;Recruitment Activity;Reporting;Research;Research Design;Research Personnel;Research Training;Resources;responsible research conduct;Science;Scientist;skills;skills training;Special Population;Structure;success;symposium;Systems Biology;Talents;Time;Training;Training Activity;Training and Infrastructure;training opportunity;Training Programs;Underrepresented Minority;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Research and Education Component


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Disability Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: SYRACUSE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: PROJECT NARRATIVE Severe traumatic brain injury (TBI) in young adults causes serious chronic consequences and lifelong disabilities that urgently require therapies for improving recovery months and years after TBI, but no treatment is available to improve TBI recovery in this chronic phase. Building on our preliminary studies that treatment with two bone marrow-generated growth factors at 3 and 6 months post-severe TBI in young adult mice improves functional outcomes, the objective of this proposed study is to determine how this treatment repairs a severe TBI-damaged brain in the chronic phase. It is expected that the proposed mechanistic studies will provide critical evidence needed for the development of an evidence-based therapy for enhancing severe TBI recovery in the chronic phase.

PI_NAMEs: ZHAO, LI-RU  (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acute;Affect;Bone Marrow;Brain;Brain imaging;Brain Injuries;brain repair;Cancer Patient;care costs;Caring;Cerebrum;chemotherapy;Chronic;Chronic Phase;Cognition;Colony-Stimulating Factors;Combined Modality Therapy;Country;Cre-LoxP;Data;Demyelinations;Dependence;Development;economic cost;efficacy evaluation;Emotional;enhancing factor;Evaluation;Event;evidence base;exosome;Family;FDA approved;Financial Hardship;functional improvement;Future;Generations;Goals;Growth Factor;Health;Hematopoietic Cell Growth Factors;improved;Individual;Injury;Ipsilateral;Learning;Life;life span;Lifelong disability;Long term disability;Long-Term Care;Macrophage;Mediating;Medical;Medical Care Costs;Memory;Modeling;Molecular;Molecular and Cellular Biology;Molecular Biology;monocyte;Motor;Mus;Natural regeneration;neural;Neurites;neurobehavioral;Neurodegenerative Disorders;novel;oligodendrocyte progenitor;Oligodendroglia;Operative Surgical Procedures;Pathology;pharmacologic;Pharmacology;Physical therapy;preclinical study;productivity loss;Proliferating;psychologic;Public Health;Recovery;Recovery of Function;recruit;Rehabilitation therapy;remyelination;repaired;Research;Research Personnel;Risk;Sensory;stem cell biology;Stem Cell Factor;stem cells;Stroke;Structure;Survivors;TBI treatment;Technology;Testing;Therapeutic;Traumatic Brain Injury;Traumatic Brain Injury recovery;Treatment Factor;two-photon;United States;white matter;Work;young adult

PROJECT_TITLE: Exploring Mechanisms Underlying SCF+G-CSF-Enhanced Recovery in ChronicTBI

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Coordinate regulation of gene expression is a fundamental property of developing multicellular systems, and its dysfunction is linked to diverse human diseases. This work has two goals. One is to understand how non-coding RNAs regulate gene expression. Second, how do metabolism, cell-cell signaling, and morphogenesis interact with programmatic gene regulation to elicit important developmental processes.

PI_NAMEs: CARTHEW, RICHARD W. (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Affect;Area;Award;Biochemical Reaction;Biological;Biological Process;Biophysics;Cell Differentiation process;Cells;Cellular Metabolic Process;Data Set;Development;Developmental Biology;Developmental Process;Drosophila genus;Energy Metabolism;experience;experimental study;flexibility;Flushing;fly;Functional disorder;Future;Gene Activation;Gene Expression;Gene Expression Regulation;Genes;Genetic;Goals;high dimensionality;Human;human disease;Human Genome;intercellular communication;Life;Link;Mammals;mathematical model;mechanical force;Metabolism;model organism;Modeling;Molecular;Morphogenesis;Nature;Organism;Pattern;Process;programs;Property;Regulation;Reiterated Genes;Research;RNA;System;Tissue Engineering;Tissues;Untranslated RNA;Work

PROJECT_TITLE: Non-coding RNAs and their mechanisms and functions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences;Opioid Misuse and Addiction;Opioids;Rehabilitation;Substance Misuse

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: Project Narrative We previously determine that deep brain stimulation (DBS) shortens the persistency of drug seeking, while increasing BDNF expression in the hippocampus. Therefore, this research project will determine the best parameters to prevent drug reinstatement, as well as to pursue pharmacological and circuit-based studies to unravel DBS’ mechanisms of action. Since our animal model of extinction, resembles exposure-based therapies in humans, the identification of DBS-induced pro-extinction molecules in the corticomesolimbic reward circuit, combined with pharmacological treatments, represents a future approach to alleviate substance use disorders.

PI_NAMEs: BARRETO ESTRADA, JENNIFER LUZ (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: addiction;Amygdaloid structure;Animal Model;Animals;antagonist;Area;Attenuated;Behavioral;Biological;Brain;Brain Diseases;Brain region;Brain-Derived Neurotrophic Factor;Cessation of life;Cholera Toxin;Clinic;Clozapine;cocaine overdose;conditioned place preference;cost estimate;COVID-19 pandemic;Cues;Data;Deep Brain Stimulation;designer receptors exclusively activated by designer drugs;Dorsal;Drug Modelings;drug seeking behavior;drug testing;Electric Stimulation;experimental study;Extinction;Frequencies;Future;Genetic;genetic approach;genetic manipulation;Genetic Techniques;Glutamates;Grant;Hippocampus;Human;immunoreactivity;Impairment;Implanted Electrodes;Injections;insight;Knowledge;learning extinction;Location;Measures;Medial;Memory;Mental disorders;Molecular;Morphine;Movement Disorders;Nervous System Disorder;Neurons;Neurosurgical Procedures;Neurotrophic Tyrosine Kinase Receptor Type 2;Nucleus Accumbens;Opiate Addiction;Opioid;opioid use disorder;Overdose;Oxides;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phase;Physiologic pulse;Pilot Projects;Population;Prefrontal Cortex;prevent;Principal Investigator;Procedures;Process;programs;Rattus;reduce symptoms;Refractory;Relapse;Reporting;Research;Research Personnel;Research Project Grants;Resistance;retrograde transport;Rewards;Rodent;Rodent Model;Role;sobriety;Substance Use Disorder;suicidal morbidity;Time;tool;Ventral Striatum

PROJECT_TITLE: BDNF in the Reward Circuit for DBS-Induced Opioid Extinction


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Due to the aging of the U.S. population, the societal burden of ADRD is on the rise. This burden disproportionately affects non-Latinx Black families, but modifiable mechanisms underlying racial inequalities in ADRD are not understood. It is therefore critical to identify new targets for interventions and policies at the individual, interpersonal, and environmental levels to reduce ADRD risk and eliminate ADRD inequalities.

PI_NAMEs: ZAHODNE, LAURA B (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Adult;Affect;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;apolipoprotein E-4;Area;Attenuated;attenuation;Behavioral;Black Populations;Black race;Brain;Censuses;Characteristics;Childhood;Cognitive;Cognitive aging;cohort;Communities;comorbidity;Control Locus;Country;critical period;Data;data archive;dementia risk;depressive symptoms;Diet;Disadvantaged;Discrimination;Disparity;educationally disadvantaged;Ensure;experience;Family;Goals;Growth;Health;Health behavior;health disparity;Health Services;Health Services Accessibility;Hippocampus;Income;Individual;Inequality;Infrastructure;Internet;Interruption;Intervention;Knowledge;late life;Leisure Activities;Life Cycle Stages;Link;longitudinal analysis;Longitudinal Studies;low socioeconomic status;Magnetic Resonance Imaging;Measures;Medical;Michigan;middle age;Modeling;mortality disparity;Neighborhoods;Neuropsychology;novel;older adult;Outcome;Participant;Pathway interactions;Physical activity;Policies;Population;Process;psychologic;psychosocial;Race;racial disparity;racial population;Recording of previous events;recruit;Religion;Reporting;Research;resilience factor;Resources;response;Risk Factors;Self Perception;social;social cohesion;social group;Social support;Social Work;Socioeconomic Status;theories;Thick;Time;United States;White Matter Hyperintensity

PROJECT_TITLE: Mechanisms of inequalities in ADRD risk across race and place in the Michigan Cognitive Aging Project

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: CORDOBA

ORG_COUNTRY: ARGENTINA

ORG_FIPS: AR

ORG_NAME: NATIONAL RESEARCH COUNCIL OF ARGENTINA

PHR: PROJECT NARRATIVE Relevance Balanced immune responses are essential for favorable outcomes during infections and comprise the crosstalk between microbial-tailored effector mechanisms able to control pathogen replication and fine-tuned regulatory pathways that prevent excessive immunopathology at the infection target tissues. This project will provide mechanistic insights about how the interplay between effector and regulatory immune responses rules the generation of cellular immunity to T. cruzi and consequently, the control of parasite replication, the immunopathology and the severity of chronic Chagas disease. This knowledge could provide new targets for the rational design of new therapeutic treatments aimed at enhancing protective cellular responses without compromising tissue homeostasis during Chagas disease and other chronic infections.

PI_NAMEs: ACOSTA RODRIGUEZ, EVA V (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acute;acute infection;Affect;Animal Model;Area;Cardiac;CD8-Positive T-Lymphocytes;Cells;Cellular Immunity;Chagas Disease;Chronic;chronic infection;Chronic Phase;Clinical;Country;Data;design;Development;Disease;Disease Progression;Economic Burden;Elements;Equilibrium;Evaluation;Flow Cytometry;FOXP3 gene;Generations;Genetic Transcription;Goals;Health;Heterogeneity;Homeostasis;Host resistance;Human;Immune response;Immunity;Immunologics;immunopathology;immunoregulation;Infection;insight;Knowledge;Latin America;Link;Location;Lymphoid;Mediating;Mediator;Metabolic;metabolic fitness;Methodology;microbial;Molecular;mortality;Mus;novel;novel therapeutics;Outcome;Parasite Control;Parasites;Parasitic Diseases;Parasitic infection;pathogen;Pathogenesis;Pathology;Pathway interactions;Patients;Peripheral;Persons;Phase;Phenotype;physically handicapped;Play;Population;prevent;programs;Property;Publishing;rational design;Regulation;Regulatory Pathway;Regulatory T-Lymphocyte;Research;residence;response;Role;Sampling;Severities;Severity of illness;social;T cell response;Testing;therapy design;Tissue Preservation;tissue repair;Tissues;transcriptome sequencing;transcriptomics;Translating;Trypanosoma cruzi;Vaccination

PROJECT_TITLE: Immunoregulation of cellular immunity and tissue homeostasis during Chagas' disease

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Data Science;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOCA RATON

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

PHR: PROJECT NARRATIVE The Florida Summer Institute in Biostatistics and Data Science (Florida SIBDS) addresses the critical shortage of biostatisticians and inclusion of a pipeline of qualified young adults from groups typically underrepresented in the behavioral and biomedical sciences. Florida SIBDS is lead by experienced senior biostatistics faculty with strong commitments to teaching, collaboration and conduct of clinical and translational research. Students will participate in learning exercises and receive mentorship by faculty and peers regarding curriculum and career goals.

PI_NAMEs: CHANG, LUN-CHING ;FREEMAN, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Academia;Achievement;Address;Advisory Committees;African American;Artificial Intelligence;Awareness;Bachelor's Degree;Behavioral;Behavioral Sciences;Big Data Methods;Biometry;Cardiovascular Diseases;Cardiovascular system;career;Clinical Research;Collaborations;college;Communicable Diseases;Communication;Computational Biology;COVID-19;Critical Thinking;Cultural Diversity;Data;Data Collection;Data Science;Data Scientist;Data Set;Databases;Disease;education access;Educational Curriculum;Educational process of instructing;Enrollment;Epidemiology;ethnic diversity;Evaluation;Exercise;experience;Faculty;faculty mentor;Florida;Funding;Future;Goals;Government;graduate school;Health;health disparity;health economics;health equity;High School Student;Hispanic Americans;Hispanic Graduate Student;Hispanic-serving Institution;HIV;improved;Industry;innovation;Institution;interest;International;Interview;Lead;Leadership;Learning;Machine Learning;Master of Science;Mathematics;medical schools;Mentorship;Methods;news;novel;Occupations;outreach;pedagogy;peer;peer coaching;Population;Positioning Attribute;Privatization;Professional Organizations;programs;Public Health;Public Health Schools;Qualifying;Qualitative Methods;Questionnaires;recruit;Reporting;repository;Research;Science;Self Efficacy;skills;social;Social Interaction;social media;Southeastern United States;Statistical Data Interpretation;student mentoring;student participation;Students;Suggestion;summer institute;System;Training;training data;Translational Research;undergraduate student;United States National Institutes of Health;Universities;university student;Vocational Guidance;web site;young adult

PROJECT_TITLE: Florida Summer Institute for Biostatistics and Data Science


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Liver Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project Narrative This proposal outlines the development and implementation of microfabricated cell culture platforms that enable the convergence of engineered cell microenvironments with targeted cell signaling manipulations. This integrated approach will facilitate unique experiments focused on the spatial and temporal mechanisms governing liver progenitor cell differentiation. In addition, these platforms could be widely applicable for studies on cell fate specification, including the optimization of stem cell differentiation protocols, as well as the examination of signaling mechanisms in cancer and degenerative disorders.

PI_NAMEs: UNDERHILL, GREGORY H (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: 3-Dimensional;Address;Adult;Anatomy;Animal Model;bile duct;bile formation;Biliary;Biochemical;Biological;Biological Models;Biomechanics;Cell Communication;Cell Culture System;Cell Culture Techniques;Cell Differentiation process;cell fate specification;Cells;cholangiocyte;Chronic;combinatorial;Communication;Cues;Degenerative Disorder;design;Development;Developmental Process;differentiation protocol;Disease;disease mechanisms study;drug testing;Duct (organ) structure;Embryonic Development;Engineering;Epithelial Cells;Exhibits;experience;experimental study;Functional disorder;Geometry;Goals;Hepatocyte;Human;human induced pluripotent stem cells;in vitro Model;Individual;Injury;insight;Intrahepatic bile duct;Investigation;jagged1 protein;Ligands;Link;Liver;liver development;Liver diseases;Liver Regeneration;Liver Stem Cell;Malignant neoplasm of liver;Malignant Neoplasms;Maps;mechanical signal;Mechanical Stress;Mechanics;Mesenchyme;Modeling;Morphogenesis;Natural regeneration;Nature;notch protein;Notch Signaling Pathway;novel;novel strategies;novel therapeutics;Pattern;Play;Portal vein structure;Process;Proliferating;Reaction;Regulation;Research;Research Personnel;response;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;stem cell differentiation;stem cell fate;stem cell fate specification;stem cell function;stem cells;Structure;Technology;Testing;therapeutic development;tissue culture;Tissue Engineering;Tissues;tool;two-dimensional;Work

PROJECT_TITLE: Microenvironmental Control of Liver Progenitor Cell Differentiation and Spatial Patterning

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: Nashville

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Alcohol abuse represents a major public health concern and is consistently among the leading causes of preventable death in the United States and worldwide. Despite significant effort, much remains unknown as to the neurobiological basis of attraction to alcohol and why some individuals are vulnerable to developing harmful drinking patterns over time. This proposal focuses on defining how the mesocortical dopamine system, which exerts powerful neuromodulatory influence over prefrontal cortex, contributes to alcohol-related decision making and the development of excessive drinking behaviors.

PI_NAMEs: SICILIANO, CODY  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Acute;addiction;Address;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol exposure;alcohol seeking behavior;alcohol use disorder;alcohol use initiation;Alcohols;Behavior;Behavioral;Biosensing Techniques;cell type;Characteristics;Chronic;chronic alcohol ingestion;Code;Consensus;Cues;Decision Making;Development;Dopamine;dopamine system;dopaminergic neuron;drinking;drinking behavior;Event;ex vivo imaging;experience;experimental study;Female;fluorescence imaging;Goals;Heavy Drinking;in vivo;Individual Differences;insight;interest;Learning;maladaptive behavior;male;Measures;Medial;Mediator;Microdialysis;Midbrain structure;Modeling;Monitor;motivated behavior;Mus;Negative Valence;nerve supply;neurobehavioral;Neurobiology;neuroregulation;Noise;Norepinephrine;Optics;optogenetics;Pattern;Periodicity;pharmacologic;Positive Valence;Predisposition;Prefrontal Cortex;presynaptic;prevent;preventable death;Procedures;Process;Property;Public Health;Punishment;resilience;Resistance;Rewards;Risk;Risk Factors;Role;Scanning;Self Administration;sensor;Signal Transduction;Slice;Specificity;Stimulus;System;Techniques;Technology;temporal measurement;Testing;Time;United States;Vulnerable Populations

PROJECT_TITLE: Mesocortical neuromodulation in punishment-resistant alcohol drinking

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10 year-olds to be followed over 10 years, to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the scientific community to address a comprehensive range of questions concerning youth development.

PI_NAMEs: BOOKHEIMER, SUSAN Y;DAPRETTO, MIRELLA  (contact)

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Behavior;Behavioral;Bioinformatics;Biological;Biological Assay;Biology;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Child Health;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Country;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;follow-up;Funding;gene interaction;Genetic;Health;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;Longitudinal Studies;marijuana use;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Pathway interactions;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Recurrence;Registries;Research;research and development;Research Personnel;Research Project Grants;Resource Informatics;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;sleep pattern;social;Social Functioning;Social isolation;social media;Specific qualifier value;Sports;Standardization;substance use;Symptoms;Technology;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;United States;vaping;Video Games;young adult;Youth

PROJECT_TITLE: 17/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UCLA


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative Sensory maps of each brain hemisphere process information from the opposite side of the body. Congenital defects in somatosensory pathways result in an abnormal map formation in the cortex. We will investigate the development and plasticity of a bilateral facial map in the cortex and how it is incorporated into the rest of the corticocortical circuitry.

PI_NAMEs: ERZURUMLU, REHA S (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Adult;Affect;Area;awake;Axon;axon guidance;barrel cortex;Behavior;behavioral phenotyping;Bilateral;Brain;Brain Stem;Calcium;Cell Nucleus;Cells;Cerebral hemisphere;Characteristics;Cognitive deficits;Congenital Abnormality;Contralateral;cortex mapping;critical developmental period;critical period;Cues;Defect;deprivation;Development;discrimination task;Disease;DNA Sequence Alteration;Electrophysiology (science);experience;Face;Functional Magnetic Resonance Imaging;functional plasticity;Funding;Genetic;Human Genetics;Image;in vivo;Investigation;Longevity;Maps;Modeling;Molecular;Morphology;Motor;motor behavior;Motor Cortex;mouse model;Mus;mutant mouse model;Mutant Strains Mice;Mutation;Neocortex;neonate;neural;neural model;neural patterning;Neurobiology;neuromechanism;Neurons;Nociception;novel;optogenetics;Outcome;Pathway interactions;Pattern;Pattern Formation;Perception;Peripheral;Positioning Attribute;Process;Resolution;response;response to injury;Rest;Rodent;Role;Sensory;Sensory Deprivation;sensory input;Sensory Process;sensory system;Side;Signal Transduction;Silicon;somatosensory;Sorting;Study models;System;Systems Development;Tactile;Testing;Thalamic structure;Tracer;Trigeminal System;Vibrissae;Visual;Weight;whisker discrimination

PROJECT_TITLE: Consequences of Developmental Defects in Somatosensory Map formation

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Colorectal Cancer;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Genetics;Human Genome;Natural Products;Nutrition;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

PHR: PROJECT NARRATIVE Colorectal cancer is the third most common cancer in the United States and second leading cause of cancer- related mortality in both men and women combined. Non-steroidal anti-inflammatory drugs, including Cox-2 inhibitors, have shown promise in reducing disease risk; however, these drugs are often associated with significant toxicities. Therefore, there is a clear need to develop other novel chemoprevention strategies. The proposed studies will lay the foundation for developing sulforaphane as a chemopreventive agent for patients at high risk for developing colorectal cancer.

PI_NAMEs: CHEN, GRACE Y. (contact);COLACINO, JUSTIN ADAM

PROGRAM_OFFICER_NAME: MALONE, WINFRED F

PROJECT_TERMS: adenoma;Affect;analog;Anti-Inflammatory Agents;APC gene;APC mutation;Biological Availability;Biological Markers;Breast Cancer Cell;Broccoli - dietary;cancer cell;cancer chemoprevention;Cancer Etiology;cancer stem cell;carcinogenesis;carcinogenicity;Cell Count;Cells;Chemoprevention;Chemopreventive Agent;Clinical Trials Design;Colectomy;Colon;colon cancer prevention;Colon Carcinoma;colon tumorigenesis;Colonic Adenoma;Colonic inflammation;Colonic Neoplasms;Colorectal Adenoma;Colorectal Cancer;colorectal cancer risk;cruciferous vegetable;cytokine;Data;Development;disorder risk;Dose;efficacy evaluation;Epithelium;Event;experimental study;Familial Adenomatous Polyposis Syndrome;Formulation;Foundations;Future;Germ-Line Mutation;Goals;Growth;high risk;Histologic;Human;Immune;In Vitro;in vitro Model;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Isothiocyanates;LGR5 gene;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;men;Modeling;mortality;mouse model;Mus;mutant;Mutation;Neoplastic Cell Transformation;Non-Steroidal Anti-Inflammatory Agents;Normal tissue morphology;novel;novel chemoprevention;Oncogenic;Oral;Organoids;Pathway interactions;Patient Agents;Patients;Pharmaceutical Preparations;Population;Pre-Clinical Model;Preparation;prevent;Prevention;Prevention strategy;Prevention trial;Proliferating;Publications;Reporter;Resistance;Risk;Risk Factors;Safety;self-renewal;Signal Pathway;Signal Transduction;single-cell RNA sequencing;standard of care;stem;stem cell biology;stem cell biomarkers;stem cell function;stem cell proliferation;stem cells;stem-like cell;stemness;Sulforaphane;Testing;Tissues;Toxic effect;transcriptome sequencing;tumor;tumor growth;tumor initiation;Tumor Suppressor Genes;Tumor Tissue;tumorigenesis;United States;WNT Signaling Pathway;Woman

PROJECT_TITLE: Targeting cancer stem-like cells and inflammation for colon cancer chemoprevention


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Genetics;Human Genome

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE The proposed “Sjögren’s Team for Accelerating Medicines Partnership (STAMP)” is strategically positioned to apply cutting-edge technologies to interrogate the tissue and systems biology of Sjögren’s disease (SjD) to better understand 1) the pathogenesis of SjD and identify therapeutic targets, and new biomarkers; and 2) disease mechanisms inherent to progression of SjD from non-SjD to SjD, and from “early SjD” to “advanced SjD”. To achieve these goals, we plan to develop a 5-year scientific research agenda, and design standardized clinical research protocols to recruit, enroll, phenotype, and collect relevant biospecimens from, observational cohorts of individuals with SjD and controls.

PI_NAMEs: BAER, ALAN N;FARRIS, A DARISE;SHIBOSKI, CAROLINE HELENE (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Acceleration;Address;Adopted;Advisory Committees;Affect;American;Arthralgia;Atlases;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;Award;Biological;Biological Markers;Calibration;California;cell type;Cells;Classification;Clinic;Clinical;Clinical assessments;Clinical Data;Clinical Research;Clinical Research Protocols;Clinical Trials;cohort;Collaborations;college;Data;deep sequencing;Derivation procedure;design;Diagnosis;Disease;DNA Methylation;Early Diagnosis;effective therapy;Enrollment;Epidemiology;European;Exocrine Glands;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;eye dryness;Fatigue;follow-up;Foundations;Functional disorder;Funding;Future;Genetic;genetic association;Genetic Heterogeneity;Genetic Predisposition to Disease;genetic variant;genome wide association study;genome-wide;Genomics;Goals;Heterogeneity;high risk;Immune;improved;Individual;Inflammation;International;Lacrimal gland structure;Lymphocytic Infiltrate;Lymphoma;Mediating;Medical Research;Medicine;Molecular;Molecular Analysis;Molecular Biology;Morbidity - disease rate;multidisciplinary;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Dental and Craniofacial Research;Natural History;Nature;New York;Nuclear;Oklahoma;Oral;Participant;Pathogenesis;Pathway interactions;Patient Care;Patient Recruitments;Patients;Phase;Phenotype;Positioning Attribute;pre-clinical;Prevalence;Protocols documentation;Quality of life;reconstruction;Recording of previous events;recruit;Research;Research Personnel;Research Priority;Resources;response;Rheumatism;Rheumatoid Arthritis;Rheumatology;Risk;risk variant;Salivary Gland Tissue;Salivary Glands;Sampling;San Francisco;scale up;Scientist;single cell mRNA sequencing;single-cell RNA sequencing;Site;Sjogren's Syndrome;Standardization;symptom management;Syndrome;System;systemic autoimmune disease;Systems Biology;Technology;Therapeutic;therapeutic target;Tissues;transcriptome sequencing;transcriptomics;Translating;Universities;Validation;whole genome;Work


NIH_SPENDING_CATS: Asthma;Biodefense and Related Countermeasures;Biotechnology;Cystic Fibrosis;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Rare Diseases

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: PROJECT NARRATIVE Asthma is a chronic lung disease affecting millions worldwide. We currently have a limited understanding of how the changes to mucus observed in disease contribute to its function. The proposed research aims to provide a new, highly valuable means to understand the impact of disease-associated changes in mucus composition to lung airway dysfunction in asthma and other related muco-obstructive lung diseases.

PI_NAMEs: DUNCAN, GREGG  (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Address;Affect;Affinity;airway epithelium;airway hyperresponsiveness;airway obstruction;Allergens;Aspergillus oryzae;Asthma;asthma exacerbation;asthmatic airway;Binding;Biochemical;Biological Models;Biological Process;biophysical properties;Biophysics;Cell Culture Techniques;Chronic lung disease;clinically relevant;Coughing;CRISPR/Cas technology;Data;defined contribution;delivery vehicle;Development;Disease;Elasticity;Engineering;Extrinsic asthma;Functional disorder;Gel;Gene Delivery;Genes;Genetic Engineering;Goals;Health;Human;Human Engineering;Immobilization;Impairment;improved;in vivo evaluation;Individual;Infection;Influenza A virus;influenzavirus;innovation;insight;Interleukin-13;Knowledge;Left;Life;Lung;Measurement;Measures;Mediating;Modeling;Molecular Biology;mouse model;MUC5AC gene;MUC5B gene;Mucins;Mucociliary Clearance;Mucous body substance;mucus clearance;mucus-associated lung diseases;Mus;new therapeutic target;novel;overexpression;particle;pathogen;Penetration;Predisposition;prevent;Property;Publishing;pulmonary function;Research;respiratory virus;Rheology;Role;Severities;Severity of illness;siRNA delivery;Small Interfering RNA;Specific qualifier value;Structure;Structure of parenchyma of lung;Surface;Symptoms;System;targeted treatment;Techniques;Testing;Tetracyclines;Therapeutic;Thick;tissue culture;tool;translational impact;translational potential;Viral;Viral Respiratory Tract Infection;Virus;Virus Diseases;viscoelasticity;Viscosity;Work

PROJECT_TITLE: Understanding alterations to mucus composition and function in asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Lung;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

PHR: The proposed research is relevant to public health because once we understand the mechanisms that control the different steps of tissue regeneration, we can better design strategies to manipulate specific aspects of the tissue damage response, while avoiding unwanted side effects, after acute injury or chronic illness. Ultimately this knowledge has the potential to guide our efforts to regrow essential human tissues such as pancreatic islets, cardiac muscle, lung alveoli, and digits or appendages, which will have a profound impact on the treatment of patients who suffer from diabetes, heart disease, chronic obstructive pulmonary disease, cystic fibrosis and traumatic injury. Therefore, the proposed research fulfills the mission of the NIH to pursue fundamental knowledge of biology that will reduce the burdens caused by chronic illness and traumatic injury.

PI_NAMEs: SMITH-BOLTON, RACHEL  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Acute;Animals;appendage;Back;Biological Models;Biology;Candidate Disease Gene;candidate identification;Cell Fate Control;Cells;Chronic Disease;Chronic Obstructive Pulmonary Disease;Cystic Fibrosis;design;Development;Diabetes Mellitus;Digit structure;Drosophila genus;flexibility;Funding;Gene Expression;Gene Expression Profile;gene regulatory network;Genetic;Genomic approach;genomic locus;Genomics;Goals;Growth Factor;Heart Diseases;Human;human tissue;Individual;Injury;innovation;Islets of Langerhans;Knowledge;Life Expectancy;Medical;Mission;Molecular;Myocardium;Natural regeneration;Outcome;Pathway interactions;Patients;Pattern;prevent;programs;Proliferating;protective factors;Public Health;Pulmonary alveolar structure;Quality of life;regenerative growth;Regenerative Medicine;Regulation;Research;response;side effect;Signal Induction;Signal Transduction;Structure;Techniques;tissue regeneration;Tissues;transcription factor;Trauma;Traumatic injury;United States National Institutes of Health;Work;wound response

PROJECT_TITLE: Genetic regulation of tissue regeneration


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Prevention;Substance Misuse

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: PUBLIC HEALTH NARRATIVE The proposed study targets the complex, prevalent, and difficult-to-treat psychiatric comorbidity of alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD). Building on promising preliminary data and provider input, this study will evaluate a new integrated behavioral intervention that synergistically combines two evidence-based treatments: Cognitive Processing Therapy (CPT) for PTSD and Relapse Prevention (RP) for AUD. This study has the potential to significantly improve patient outcomes, transform clinical practice, advance the science of comorbidity in this area, and reduce expenditures associated with AUD and PTSD.

PI_NAMEs: BACK, SUDIE E;VUJANOVIC, ANKA ANNA (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Address;Aftercare;Age;Alcohol consumption;alcohol use disorder;Alcohols;Area;Back;Behavior;behavior change;Behavior Therapy;Behavioral Mechanisms;Biological Markers;Client satisfaction;Clinical;clinical outcome measures;clinical practice;Cognition;Cognitive;Cognitive Therapy;Collaborations;combat injury;Combined Modality Therapy;comorbidity;Complex;Data;design;Disease;distress tolerance;drinking;Dropout;Ecological momentary assessment;effective therapy;efficacy evaluation;efficacy testing;Event;evidence base;Evidence based treatment;Expenditure;experience;Exposure to;Feeling hopeless;Feeling suicidal;follow-up;Frequencies;Functional impairment;Guilt;Health Personnel;implementation outcomes;improved;Individual;innovation;Integrative Therapy;interest;Intervention;intervention effect;Intoxication;Investigation;Manuals;Measures;Memory;Mental disorders;Mental Health;Mission;Monitor;National Institute on Alcohol Abuse and Alcoholism;negative emotional state;novel;Outcome;Participant;Patient Self-Report;Patient-Focused Outcomes;Patients;pilot test;Post-Traumatic Stress Disorders;practice setting;preventive intervention;Protocols documentation;Provider;psychiatric comorbidity;Public Health;Qualifying;Randomized;randomized, clinical trials;reduce symptoms;reduced alcohol use;relapse prevention;Reporting;Research;Research Design;Research Personnel;response;retention rate;Safety;Science;Severities;Standardization;Strategic Planning;substance use;Substance Use Disorder;suicidal risk;Surveys;symptomatology;Symptoms;targeted treatment;Testing;Time;timeline;Trauma;trauma exposure;traumatic event;treatment choice;Treatment outcome;uptake;Visit;Work

PROJECT_TITLE: Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and Co-Occurring PTSD: A Randomized Clinical Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-A(02)]