NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition;Obesity;Sleep Research

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Public Health Statement: Obesity and Alzheimer’s disease (AD) devastate millions of Americans and place a tremendous burden on our healthcare system. Necessities of modern society put immense pressure on human physiology by forcing incongruity between endogenous circadian rhythms and environmental cycles, which worsens a range of health issues including obesity associated maladies and AD. This project aims to identify the neuronal circuits and the molecular players that control circadian rhythms and therefore identify therapeutic targets to circumvent these pathologies.

PI_NAMEs: GULER, ALI  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Acceleration;adverse outcome;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;American;Astronomy;Behavior;behavioral response;Biological Process;circadian;Circadian desynchrony;circadian pacemaker;Circadian Rhythms;Cues;Diet;Dopamine Receptor;Dopaminergic Cell;dopaminergic neuron;Event;Exercise;Food;Food Access;food consumption;food restriction;Genetic Transcription;Goals;Health;Healthcare Systems;high risk;Hour;Human;Hypothalamic structure;insight;Laboratories;Light;Lighting;Metabolic;Metabolic Diseases;Metabolic dysfunction;Midbrain structure;Modernization;Molecular;mouse model;neural circuit;Neurodegenerative Disorders;neuronal circuitry;Neurons;novel;Obesity;Pathology;Pathway interactions;Periodicity;Persons;Physiological;Physiology;pressure;Prevalence;Public Health;Recurrence;reduce symptoms;response;Rewards;Signal Transduction;Social Interaction;Societies;Stress;suprachiasmatic nucleus;Target Populations;therapeutic target;Time;Weight Gain;Work

PROJECT_TITLE: Interplay between circadian and reward pathways in homeostatic response and pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PI_NAMEs: ZENISEK, DAVID PAUL (contact)

PROJECT_TERMS: Biomedical Research;Cells;Communities;Core Grant;data acquisition;Data Analyses;Data Collection;Development;digital;digital imaging;Equipment;Goals;Image;Image Analysis;imaging approach;imaging modality;Imaging Techniques;Imaging technology;Individual;Investments;medical schools;Methods;Microscope;Microscopic;microscopic imaging;Microscopy;molecular imaging;Neurosciences;novel;Ophthalmology;optical imaging;Optics;Play;Postdoctoral Fellow;programs;Research;Research Personnel;Resources;Role;Scientist;Structure;student training;Students;success;Techniques;Technology;Tissues;Training;Universities;virtual;Vision;Vision research;vision science;Visual System

PROJECT_TITLE: Imaging Core


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Obesity

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: The obesity pandemic has resulted in a number of related metabolic diseases such insulin resistance and type 2 diabetes reaching epidemic proportions in the U.S. and across the globe. Among the more serious sequelae arising from these conditions is cardiac dysfunction, a state characterized by metabolic and structural remodeling of the heart muscle that may eventually progress to heart failure. The studies outlined in this proposal will define the mechanisms connecting an emergent feature of cardiometabolic disease, perturbed branched chain keto acid metabolism, to cardiac dysfunction.

PI_NAMEs: MCGARRAH, ROBERT WALKER (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Acute;Address;Animal Model;branched chain alpha ketoacid dehydrogenase;Branched-Chain Amino Acids;Cardiac;Cardiometabolic Disease;Catabolism;Chronic;Citric Acid Cycle;comparison control;Complex;Data;Development;Diabetes Mellitus;Disease;Down-Regulation;EFRAC;Enzymes;Epidemic;Exposure to;flexibility;FRAP1 gene;Genetic;genetic approach;Goals;Heart;Heart failure;heart function;Impairment;in vivo;insight;Insulin Resistance;Isoleucine;Keto Acids;Knockout Mice;Knowledge;Leucine;Liver;MAP Kinase Gene;MAPK3 gene;Mediating;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;Mitochondria;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial dysfunction;Myocardium;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Obesity;oxidation;Oxidoreductase;pandemic disease;Pathway interactions;Perfusion;pharmacologic;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Physiology;Plasma;preservation;pressure;Protein Biosynthesis;Proteins;Regional Perfusion;Role;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Site;stable isotope;Structure;Techniques;therapeutic target;Tissues;transamination;Valine;Work

PROJECT_TITLE: Mechanisms Connecting Dysregulated Branched-Chain Alpha-Ketoacid Metabolism to Cardiac Dysfunction

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Organ Transplantation;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Frailty has been shown to be a critical determinant of outcomes in patients with cirrhosis in the outpatient setting, but there is a great unmet need to understand the role of frailty in patients with acutely decompensated cirrhosis in the inpatient setting, who comprise approximately one-third of patients undergoing liver transplantation. We propose to address this unmet need by developing and validating a novel inpatient frailty index for acutely ill patients with cirrhosis undergoing liver transplantation and examining the added value of inpatient frailty assessments on prediction of outcomes after liver transplantation, including mortality, functional well-being, and healthcare utilization.

PI_NAMEs: LAI, JENNIFER C. (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Acute;acute care;Address;American;Biological;Chronic;Cirrhosis;Clinical;clinical practice;clinical predictive model;cost;Data;Decision Making;disability;Equilibrium;Evaluation;Event;Extrahepatic;Eye;frailty;Functional impairment;functional status;Goals;Hand;Hand Strength;Health;health care service utilization;health related quality of life;Healthcare Systems;Hepatology;Hospitalization;Hour;improved;indexing;Individual;Inpatients;Intercept;Length of Stay;Liver;liver function;liver transplantation;Machine Learning;Malnutrition;Measures;model building;Modeling;mortality;Muscular Atrophy;novel;Operative Surgical Procedures;Outcome;outcome prediction;Outpatients;Patients;Personal Satisfaction;Physiological;Population;Population Dynamics;Portal Hypertension;post-transplant;Predictive Value;Recovery;recruit;Research;Role;Severities;Societies;Standardization;stressor;Surveys;Testing;theories;Time;tool;Transplant Recipients;Transplantation;Transplantation Surgery;Validation

PROJECT_TITLE: Investigating the role of frailty on outcomes in acutely ill patients with cirrhosis undergoing liver transplantation in the acute care setting

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Genetic inactivation of the tumor suppressor p53 drives progression to malignancy during the initiation of pancreatic cancer. This proposal aims to investigate the mechanisms of p53 engagement and action during sporadic pancreatic cancer initiation, as well as the immediate consequences of p53 loss, using novel tools that allow us to examine the critical transition from benign to malignant disease. This work will provide insights into early events in the formation of pancreatic cancer and the many other p53-mutant cancers, and these insights may lead to new strategies for cancer prevention and treatment.

PI_NAMEs: LOWE, SCOTT W. (contact);PE'ER, DANA

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Acceleration;Address;Apoptosis;Back;Benign;Biological;cancer initiation;cancer prevention;cancer therapy;cancer type;Cell Physiology;Cell Proliferation;Cell Survival;cell transformation;Cells;Computer Analysis;computerized tools;Consensus;Data;Development;Disease;Disease Progression;DNA Damage;DNA Methylation;Event;Gene Expression;Genetic;Genetic Transcription;Genome Stability;Genomic Instability;High Prevalence;Human;in vivo;Injury;insight;Intercept;Knowledge;KRAS oncogenesis;KRAS2 gene;Lesion;Link;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Metabolism;Modeling;mouse model;Mus;mutant;Mutate;Mutation;Mutation Detection;Neoplasms;neoplastic cell;Neoplastic Cell Transformation;novel;Null Lymphocytes;Oncogene Activation;Oncogenes;Oncogenic;Pancreas;Pancreatic Ductal Adenocarcinoma;Pancreatic Ductal Carcinoma;Polyploidy;Precancerous Conditions;premalignant;Premalignant Cell;prevent;Process;Prognosis;programs;Research;restoration;Role;senescence;Signal Transduction;single cell analysis;Testing;tool;TP53 gene;transcription factor;tumor;tumor heterogeneity;Tumor Promotion;Tumor Suppressor Proteins;tumorigenesis;Work

PROJECT_TITLE: Mechanisms of p53 Engagement and Action at the Benign-to-Malignant Transition in Sporadic Tumorigenesis

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Substance Misuse

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative: The goal of this proposal is to examine how alcohol prevents the breakdown of specialized fat-storage depots in liver cells (lipid droplets) resulting in lipid accumulation and alcohol-induced fatty liver disease. We hypothesize that alcohol exposure leads to fatty liver by altering key degradative and quality control processes normally used by the cell to promote utilization of lipid droplets. This proposal will take advantage of state-of-the-art cell biological and imaging technologies coupled with profiling of lipids and proteins found in lipid droplets, integrated with studies performed in genetic mouse models to define how liver lipid catabolism is compromised during chronic alcohol exposure.

PI_NAMEs: CASEY, CAROL A. (contact);MC NIVEN, MARK A.

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Address;Affect;alcohol exposure;alcohol prevention;Alcoholic beverage heavy drinker;Alcoholic Fatty Liver;Alcoholic Liver Diseases;Alcoholic steatohepatitis;Alcohols;ATP phosphohydrolase;Attenuated;Autophagocytosis;Autophagosome;Biological;Biology;Catabolism;cell injury;Cell Physiology;Cells;Chronic;Cirrhosis;Coupled;Dependovirus;Disease Pathway;Endoplasmic Reticulum;endoplasmic reticulum stress;Ethanol;Event;event cycle;Excision;Exposure to;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;feeding;Fibrosis;Funding;Genetic;Genome;Goals;Health;Hepatic;Hepatocyte;Image;Imaging technology;Individual;Injury;insight;Investigation;lipid biosynthesis;lipidomics;Lipids;Liver;liver injury;Lysosomes;Mediating;Membrane;Membrane Proteins;Molecular;Molecular Chaperones;mouse model;multicatalytic endopeptidase complex;Mus;National Institute on Alcohol Abuse and Alcoholism;novel;Organelles;Outcome;oxidation;Pathway interactions;Patients;pharmacologic;prevent;Process;Property;Proteins;Proteome;Proteomics;Quality Control;repaired;Research Personnel;Role;Serotyping;Severities;Surface;Technology;Testing;Therapeutic;Time;trafficking;Triglycerides;Ubiquitin;Ubiquitination;unfoldase;valosin-containing protein

PROJECT_TITLE: Altered Lipid Droplet Trafficking:  Role in Alcoholic Fatty Liver Disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Skin Cancer

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Melanoma is the fifth most common form of cancer in adults (men and women) and is the deadliest form of skin cancer (NCI-SEER-Database, 2019), and has been rising in the United States and worldwide (Karimkhani et al., 2017; Schadendorf et al., 2018), with an estimated 96,480 adults (57,220 men and 39,260 women) diagnosed with melanoma in the United States in 2019, accounting for 5.5% of all new cancer cases and resulting in 7,230 deaths (1.2% of all cancer deaths). While the treatment of metastatic melanoma has undergone a dramatic transformation over the past decade with the advent of molecular targeted therapy and immunotherapy, additional therapeutic approaches are needed for patients resistant to available targeted and immune treatments. We have identified TANK-binding kinase 1 (TBK1) is an emerging target to overcome resistance to cancer immunotherapy and aim to define the cell type specific roles of TBK1 in tumor immunity.

PI_NAMEs: JENKINS, RUSSELL WILLIAM (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Accounting;Adult;anti-tumor immune response;Biological Markers;Biological Models;Biology;cancer cell;cancer immunotherapy;CD8-Positive T-Lymphocytes;Cell Death;Cell Physiology;cell type;Cells;Cessation of life;Clinical;conditional knockout;cytokine;cytotoxicity;Data;Databases;Development;Diagnosis;effective therapy;effector T cell;exhaust;exhaustion;Experimental Models;Functional disorder;Genes;Genetic;Genetic Screening;Goals;Immune;immune checkpoint blockade;Immune Evasion;Immunotherapy;In Vitro;in vivo;Inflammatory;Inflammatory Response;insight;Knockout Mice;Laboratories;loss of function;Lymphoid Cell;Macrophage;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;Melanoma patient;men;Metastatic Melanoma;Modeling;molecular targeted therapies;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Nature;neoplastic cell;novel;novel therapeutic intervention;Patients;PD-1 blockade;PD-1/PD-L1;PDL1 pathway;pharmacodynamic biomarker;pharmacologic;Population;Production;progenitor;Protein Kinase;Publishing;Regulation;Resistance;response;restraint;RIPK1 gene;Role;Signal Transduction;single-cell RNA sequencing;Skin Cancer;success;T-Lymphocyte;TANK-binding kinase 1;Testing;Therapeutic;TNF gene;tool;treatment strategy;tumor;Tumor Immunity;tumor microenvironment;Tumor-infiltrating immune cells;United States;Woman

PROJECT_TITLE: Dissecting the tumor-intrinsic and -extrinsic roles of TBK1 in tumor immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIR-W(01)Q]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Our lab focuses on the structural and functional studies of the molecular machines involved in the chemical modifications of macromolecules. We use structural biology approaches to uncover the molecular details of the machinery and adopt chemical biology and protein engineering approaches to develop new tools and methods for the functional studies. Currently we are focusing on two systems, the p97 related ubiquitination system and the Vault related ADP-ribosylation system.

PI_NAMEs: ZHAO, MINGLEI  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Adopted;ADP ribosylation;Biology;Chemicals;cofactor;Complex;COVID-19 pandemic;Disease;Drug resistance;Enzymes;Eukaryotic Cell;Genetic Markers;Goals;Human;human disease;Influenza vaccination;inhibitor;Innate Immune Response;insight;Learning;Link;macromolecule;major vault protein;Malignant Neoplasms;Methods;Modification;Molecular;Molecular Biology;Molecular Machines;Mutation;Neurodegenerative Disorders;particle;Play;Process;Protein Engineering;Proteins;proteostasis;response;Ribonucleoproteins;Role;structural biology;Structure;System;tool;Transcriptional Regulation;Translational Regulation;Ubiquitin;Ubiquitination;vaccine development

PROJECT_TITLE: Structural and Functional Studies of Molecular Machines Involved in Chemical Modifications of Macromolecules

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Sulfur mustard (mustard gas) and arsenicals such as lewisite still represent major threats as vesicant agents in chemical warfare and terrorism. We plan to test a new antioxidant as a countermeasure and to investigate the initiation of vesicant skin injury at a subcellular and single cell level to help develop better treatment for vesicant exposures.

PI_NAMEs: ANDERSEN, BOGI  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Abbreviations;Acetylcysteine;Animal Model;Antioxidants;Arsenicals;Basal lamina;Biochemical;Bulla;cell injury;Cells;Chemical Structure;Chemical Warfare;Chromatin;cobinamide;Collagen;Cyclic GMP-Dependent Protein Kinases;Dermal;effectiveness testing;efficacy testing;Epidermis;experimental study;fluorescence lifetime imaging;Foundations;Genes;Genetic Transcription;Genomics;Goals;Histologic;Human;Image;Imiquimod;in vivo;in vivo evaluation;in vivo fluorescence;Injury;innovation;insight;Interferons;keratinocyte;Knowledge;Langerhans cell;Late Effects;Lead;lewisite;Mechlorethamine;Metabolic;Metabolism;Methods;Modeling;Monitor;mouse model;Mus;Mustard;Mustard Compounds;Mustard Gas;Nature;Nitric Oxide;Nitrogen;novel therapeutic intervention;novel therapeutics;Nuclear;Oxidants;oxidative damage;Oxidative Stress;Oxides;Oxygen;Pathogenesis;Pathogenicity;Peroxonitrite;Phase;Publishing;Reactive Nitrogen Species;Reactive Oxygen Species;Research;response;Role;single-cell RNA sequencing;Skin;skin damage;Skin injury;Skin repair;Structure;Sulfides;Superoxide Dismutase;Technology;Terrorism;Testing;Time;tool;Toxic effect;Transplantation;Vesicants;Work;wound healing

PROJECT_TITLE: The Initiation of Vesicant Skin Injury at a Single Cell Level


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: In response to shear, microvascular dilation occurs via endothelial release of NO in healthy individuals and mitochondrial derived H2O2 in stress or in patients with coronary disease. We hypothesize that mitochondrial fission/fusion is responsible for this change in mediator of dilation. Resulting information could have profound impact on regional blood flow and on oxidative-stress induced cardiovascular disease.

PI_NAMEs: BEYER, ANDREAS M (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Acute;acute stress;Adipose tissue;Age;arteriole;Blood flow;Blood Vessels;cancer therapy;cardioprotection;Cardiovascular Diseases;Cardiovascular Pathology;cardiovascular risk factor;Cell Proliferation;Cells;Chronic;clinical diagnosis;Coronary;Coronary Arteriosclerosis;Coronary heart disease;Data;Development;Dilator;Disease;Dynamin;Elements;Endothelial Cells;Endothelium;Equilibrium;Exhibits;Exposure to;Functional disorder;Generations;Genetic;Glucose;Goals;Human;Hydrogen Peroxide;Hypoxia;Impairment;improved;In Vitro;Individual;Inflammation;Inflammatory;Investigation;knock-down;Learning;Link;Mediating;Mediator;Microcirculation;Mitochondria;Morphology;Nitric Oxide;novel;Outcome;overexpression;Oxidation-Reduction;Oxidative Stress Induction;paracrine;Pathway interactions;Patients;pharmacologic;Phenotype;Physiological;preconditioning;pressure;prevent;Process;Production;Proteins;Publishing;Regional Blood Flow;Regulation;Resistance;response;Risk Factors;Risk Reduction;Role;Signal Pathway;Signal Transduction;Smooth Muscle;Stimulus;Stress;stressor;Testing;Therapeutic;tissue injury;Tissues;tool;Toxic effect;treatment strategy;Up-Regulation;Vascular Endothelial Cell;Vascular Endothelium;vascular injury;vascular stress;Vasodilator Agents;Vasomotor;Work

PROJECT_TITLE: Critical role of Mitochondrial Fission/Fusion in Regulation of Microvascular Endothelial Function

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

ORG_CITY: ATHENS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OHIO UNIVERSITY ATHENS

ORG_STATE: OH

PHR: Project Narrative - Public Health Relevance: The proposed research is relevant to public health because understanding the mechanisms by which GH induces joint tissue dysfunction has the potential to lead to new disease-modifying-drugs for preventing osteoarthritis. The project is relevant to NIH’s mission because it develops fundamental knowledge about the causes and potential therapies for reducing the burdens of human disability associated with osteoarthritis.

PI_NAMEs: ZHU, SHOUAN  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Acromegaly;Adult;Affect;Age;Age Years;aggrecan;Aging;aging related;antagonist;anti aging;Arthralgia;articular cartilage;Biological Assay;Biological Markers;Blood;Bone Spur;bovine growth hormone;Cartilage;cartilage degradation;Cartilage Matrix;Cell Physiology;Cells;Cellular Metabolic Process;Childhood;Chondrocytes;Clinical;Collagen;collagenase 3;Contralateral;cost;Data;Degenerative polyarthritis;Development;Diabetes Mellitus;disability;Disease;effective intervention;Enzymes;Epiphysial cartilage;Epitopes;fatty acid oxidation;FDA approved;femur head;Functional disorder;Genes;Genus Hippocampus;Growth;growth hormone deficiency;Growth Hormone Receptor;Growth Hormone Secreting Pituitary Adenoma;Health;Hip region structure;Histologic;Hormonal;hormonal signals;Hormone secretion;Human;Hyperalgesia;Hypertrophy;In Vitro;in vivo;Incidence;Inflammation;insight;Interleukin-1 beta;JAK2 gene;joint destruction;joint function;Joints;Knee;Knee joint;Knowledge;Laboratories;Lesion;Lipolysis;liquid chromatography mass spectrometry;Literature;Malignant Neoplasms;Measurement;Measures;Metabolic;Metabolism;metabolomics;Methods;Mission;mouse model;Mus;Neck;new therapeutic target;novel;off-label use;older adult;overexpression;Pain;Paraffin;Pathology;Patients;pegvisomant;Peripheral;Pharmaceutical Preparations;Pharmacotherapy;postnatal;Pre-Clinical Model;pressure;prevent;Process;Production;Public Health;public health relevance;receptor;Regulation;Reporting;Research;Role;Serum;side effect;Signal Transduction;Skeletal system;Somatotrophin increased;Somatotropin;Spirometry;Stat5 protein;Synovitis;Testing;Therapeutic;Time;Tissues;TNF gene;United States National Institutes of Health

PROJECT_TITLE: Growth hormone regulating chondrocyte metabolism for osteoarthritis development

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Heart Disease;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative The proposed research project will improve public health by improving our understanding of the impact of air pollution exposure during pregnancy and early in life on cardiovascular health development. This will help inform cost-effective policies to protect children during this critical window of susceptibility.

PI_NAMEs: JACK, DARBY ;LEE, ALISON G (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: 12 year old;4 year old;8 year old;Accounting;Affect;Age;air monitoring;Air Pollution;ambient air pollution;Anthropometry;arm;Arsenic;attributable mortality;Biological Markers;Birth;Birth length;Blood Pressure;Body mass index;Cadmium;Carbon Monoxide;Cardiotoxicity;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Cessation of life;Child;Childhood;cohort;comparison control;cooking;Cookstove;cost effective;cost effective intervention;Data;data repository;Development;Diastolic blood pressure;disability-adjusted life years;disorder risk;Environmental Exposure;Environmental Risk Factor;evidence base;Exposure to;Fasting;fine particles;Fire - disasters;follow-up;Future;Gases;Ghana;Glucose;Grant;Growth;Health;Height;Heterogeneity;Hour;Household;Household Air Pollution;improved;in utero;infancy;Infant;Intention;Intervention;Intervention Studies;Lead;Life;Life Cycle Stages;Lipids;Literature;Longitudinal Studies;low and middle-income countries;Low Birth Weight Infant;lung health;Manganese;Measurement;Measures;Mediation;Metal exposure;Metals;Methods;Monitor;Morbidity - disease rate;mortality;Nickel;Outcome Assessment;Persons;Petroleum;Policies;Predisposition;Pregnancy;Pregnant Women;premature;prenatal;Prevention strategy;programs;Public Health;Randomized;Research;Research Project Grants;response;Rest;Risk Estimate;Risk Reduction;Smoke;Source;Spottings;Tobacco smoke;Toxic effect;treatment arm;urinary;Urine;Vanadium;Weight

PROJECT_TITLE: Early life household air pollution, metal composition and cardiovascular health: Evidence from GRAPHS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(91)S]


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative The immune system must be carefully balanced to allow for elimination of infections, while at the same time avoiding unwanted or overly vigorous immune responses that can result in autoimmunity or immune-mediated organ damage. Immune balance is maintained in part by a type of immune cell known as the regulatory T cell (Treg). Here we will explore the possibility that a specific protein, known as Tim-3, is an important regulator of Treg function. We will also seek to identify specific intracellular molecules that are used by Tim-3 to control the function of Treg. These studies may lead to better therapies for treating cancer by enhancing a patient’s own immune response to the cancer.

PI_NAMEs: FERRIS, ROBERT L.;KANE, LAWRENCE P. (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Ablation;Adoptive Cell Transfers;Attention;Autoimmunity;cancer therapy;cancer type;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;cell type;Cells;checkpoint therapy;Clinical;Clinical Trials;CTLA4 gene;Data;Defect;Development;Equilibrium;exhaust;exhaustion;Funding;Generations;Growth;Head and Neck Cancer;Human;Immune;immune checkpoint blockade;Immune response;Immune system;Immune Tolerance;Immunity;Immunotherapy;improved;In complete remission;in vivo;Infection;inhibitor;Knock-out;Ligands;Logic;Maintenance;Malignant Neoplasms;Mediating;Metabolic;Modality;Modeling;Molecular Profiling;Monoclonal Antibodies;mouse model;Mus;neoantigens;neoplasm immunotherapy;novel;novel strategies;Organ;Outcome;Patients;PD-1 blockade;PD-1 pathway;PD-1/PD-L1;PD-L1 blockade;Peripheral;Phenotype;programmed cell death protein 1;Proteins;Publishing;Regulatory T-Lymphocyte;response;restraint;Role;Sea;Signal Transduction;single-cell RNA sequencing;Solid Neoplasm;success;synergism;T cell infiltration;T cell receptor repertoire sequencing;T cell therapy;T-Cell Depletion;T-Cell Development;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Time;Tissues;trafficking;Translations;tumor;Tumor Immunity;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Work

PROJECT_TITLE: Mechanisms of PD-1 and Tim-3 crosstalk in tumor-infiltrating lymphocytes

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Precision Medicine;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Breast tissue stroma plays an important role in sustaining normal breast tissue structure and function and regulating activity of the breast epithelium. While stroma in breast tumors has been widely explored, the stromal contributions to early stages of breast tumor development are poorly understood. To fill this gap, we propose a highly novel investigation that will shed light on associations of selected stromal markers with reproductive breast cancer risk factors and will explore how specific markers could be used to improve breast cancer risk prediction in a large segment of high-risk women undergoing routine breast biopsies and/or in women with high density of breast tissue on the mammograms which could pave a way for novel personalized breast cancer prevention and surveillance strategies.

PI_NAMEs: TAMIMI, RULLA M;YAGHJYAN, LUSINE  (contact)

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Address;Age;Age at Menarche;age related;Architecture;Area;automated image analysis;Benign;biomarker identification;Biometry;Biopsy;Biopsy Specimen;Birth;Breast;Breast biopsy;Breast Cancer Epidemiology;Breast Cancer Prevention;Breast Cancer Risk Factor;Breast Carcinogenesis;breast density;Breast Diseases;Breast Feeding;breast pathology;Cancer Biology;Cancer Etiology;Cancer Patient;carcinogenesis;case control;Characteristics;Clinical Management;cohort;Collaborations;Complex;Data;Data Collection;density;design;Development;differential expression;epidemiology study;Epithelium;Extracellular Matrix;Fibroblasts;First Births;follow-up;Future;General Population;High Risk Woman;Histopathologic Grade;Human;Image Analysis;improved;individualized prevention;Intervention;Investigation;Knowledge;Life;Link;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;mammary epithelium;Mammary Gland Parenchyma;Mammary Neoplasms;Mammographic Density;Mammography;Metastatic Neoplasm to Lymph Nodes;Methodology;MMP14 gene;Molecular;Molecular Profiling;Nested Case-Control Study;novel;Nulliparity;Nurses' Health Study;Organ;Outcome;parity;parous;patient population;Pharmacologic Substance;Play;Population Study;predictive marker;Prevention strategy;Primary Prevention;Process;Productivity;Proliferating;prospective;Prospective cohort;Public Health;Recording of previous events;repository;reproductive;Reproductive History;Resources;Risk;Risk Factors;Risk Management;risk prediction;Risk Reduction;Role;Sampling;Signal Transduction;stem cell biomarkers;stem cells;Stromal Cells;Structure;surveillance strategy;targeted treatment;Tenascin;tissue repair;tissue resource;Tissues;Translating;tumor;tumor initiation;Universities;Variant;Washington;Woman;Women's Health;Women's study

PROJECT_TITLE: Stromal contributions to breast carcinogenesis

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetic Testing;Genetics;Health Services;Human Genome;Prevention;Primary Health Care

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative Over the past two decades, colorectal cancer (CRC) has been rising rapidly in persons under 50 years of age, who are also diagnosed with more advanced-stage cancer following the presentation of symptoms. Given early detection of CRC is key to improving survival, the U.S. Preventive Services Task Force now recommends that the age at which population-based screening by colonoscopy or stool-based methods in asymptomatic persons should be reduced to 45 years, even though uptake is low among asymptomatic persons in general. We plan to identify a panel of biomarkers by studying young-onset CRC patients, and from these, develop a new high- accuracy blood-based screening test, which we will compare against the existing ColoVantage® (“mSEPT9”) blood-based test to detect CRC in persons under 50 years of age.

PI_NAMEs: HAILE, ROBERT WILLIAM;HITCHINS, MEGAN P (contact);YOU, SUNGYONG

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Address;adenoma;Adherence;Adult;advanced disease;Advisory Committees;Age;age group;Age of Onset;Age Years;aged;bioinformatics pipeline;Biological Assay;biomarker identification;biomarker panel;Blood;cancer type;Case/Control Studies;Characteristics;Colon;colon cancer patients;Colonoscopy;Colorectal;Colorectal Cancer;colorectal cancer screening;colorectal cancer treatment;cost effective;Data;Data Set;Detection;Diagnosis;Diagnostic;diagnostic accuracy;Disease;DNA Markers;DNA Methylation;DNA methylation profiling;Early Diagnosis;early onset;early onset colorectal cancer;Eligibility Determination;Ensure;epigenomics;FDA approved;Feces;follow-up;Formalin;Freezing;Friends;head-to-head comparison;high risk;Human;Hypermethylation;improved;Incidence;Leukocytes;Life;Malignant Neoplasms;metastatic colorectal;Methods;Methylation;methylation biomarker;methylation testing;minimally invasive;mortality;Mucous Membrane;Mutation;Neoplasms;novel;nuclease;Paraffin Embedding;Pathway interactions;Patients;Performance;Persons;Plasma;Population;population based;Preventive service;Primary Neoplasm;pyrosequencing;Recommendation;Research Design;Resistance;Risk;Sampling;screening;Screening for cancer;screening guidelines;SEER Program;Series;Signal Transduction;Site;specific biomarkers;Specificity;stool sample;surveillance data;Symptoms;Testing;The Cancer Genome Atlas;Time;Tissues;Triage;tumor;tumor DNA;Tumor stage;United States Preventative Services Task Force;uptake;Validation

PROJECT_TITLE: Discovery and verification of methylated circulating tumor DNA markers for the detection of colorectal cancer in subjects under 50 years of age

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE The modern rise in myopia has received a lot of attention and is of a major concern because myopic individuals with abnormally elongated eye are at risk of developing irreversible blinding diseases including retinal detachment, macular degeneration, and glaucoma. Thus, there is an urgent unmet public health need for interventions aimed at controlling abnormal growth of the eye and thereby, preventing or slowing progression of myopia. We will utilize myopic animal models to determine factors that control eye's growth, which will guide us to identify new therapeutic targets to manage myopia.

PI_NAMEs: NAIR, KAYARAT SAIDAS  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Acceleration;Affect;Agonist;Animal Model;Attention;beta catenin;Biochemical;Blindness;Callithrix;Cell Culture Techniques;Cell Physiology;cell type;Clinical;conditional mutant;Cues;Defect;Deletion Mutation;Dependovirus;deprivation;Development;Disease;emmetropization;experimental study;Extracellular Matrix;Eye;falls;Gene Targeting;Genetic;genetic approach;Genetic Processes;Genetic study;Glaucoma;Goals;Growth;Human;Hyperopia;Image;Individual;insight;Intervention;Intrinsic drive;Investigation;Length;lens;lens induction;Link;Macular degeneration;Mediating;Mediator;Messenger RNA;Microphthalmos;Modernization;Molecular;mouse model;Muller's cell;Mus;Mutant Strains Mice;Mutation;Myopia;new therapeutic target;Optics;overexpression;Pathogenesis;Pathway interactions;postnatal;postnatal development;prenatal;Prevalence;prevent;Process;programs;Proteomics;Public Health;Refractive Errors;Regulation;response;Retina;Retinal Detachment;Risk;Role;Sclera;Series;Serine Protease;Serine Proteinase Inhibitors;Signal Transduction;Structure of retinal pigment epithelium;targeted treatment;Testing;therapeutic target;Time;Transgenic Organisms;Translating;trypsin-like serine protease;Variant;Vision;Visual;WNT Signaling Pathway

PROJECT_TITLE: Characterizing the Molecular Mechanisms of PRSS56-Dependent Ocular Growth and Refractive Error

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: NORMAN

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: Project Narrative The proposed research aims to define how thermal sensations and thermoreceptor mechanisms inside the mouth affect ingestive and taste-guided behavior. Understanding these concepts will be important for delineating how sensory mechanisms involved with flavor influence ingestive decisions that impact nutritional status and health.

PI_NAMEs: LEMON, CHRISTIAN H (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Ablation;Affect;Alcohol dependence;Anorexia Nervosa;Area;Behavior;behavior test;Behavioral;Biology;Chills;cold temperature;Complement;Complement component C8;Coupled;Data;Desire for food;Development;Disease;Engineering;epithelial Na+ channel;Esthesia;experience;Feeding behaviors;Fiber;Food;Food Preferences;Food Selections;Genes;Goals;Health;hedonic;Human;Impairment;Individual;Intake;Ion Channel;Liquid substance;Measures;Mediating;Menthol;Methods;mimetics;Modality;Molecular;mouse genetics;Mus;neural;Neurobiology;Neurons;Nociception;nociceptive response;Nutritional status;Obesity;Oral;oral behavior;Oral cavity;oral sensory;orofacial;Pathway interactions;Pattern;Positive Valence;preference;Process;Proteins;receptor;Research;response;Rest;Role;Sampling;sensor;Sensory;sensory mechanism;Series;Signal Transduction;Skin;Smell Perception;somatosensory;Structure of trigeminal ganglion;System;Taste Bud Cell;Taste Buds;Taste Perception;Taste preferences;taste stimuli;Temperature;Temperature Sense;Testing;Thermoreceptors;Tongue;tool;Trigeminal nerve structure;Trigeminal System;TRP channel;TRPV1 gene;Tube;Vanilloid;warm temperature;Water;Wild Type Mouse

PROJECT_TITLE: Temperature and thermogustatory preferences

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Antimicrobial Resistance;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases

PHR: Project Narrative Bacterial infections of the cornea are a major cause of vision loss and are relevant to the NIH's and NEI's mission. We have recently determined that over the last 25 years a more vision threatening mutant form of bacteria is rapidly increasing in frequency. Our project will determine why these mutants are more virulent, and will raise awareness of this problem, which will aid in public health and will find information that can help prevent vision loss due to infections of the eye.

PI_NAMEs: SHANKS, ROBERT M (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Address;Alleles;Animal Model;anti-microbial peptide;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Awareness;Back;Bacteria;Bacterial Antibiotic Resistance;Bacterial Genome;Bacterial Infections;bacterial resistance;Blindness;Cicatrix;Clinical;clinical diagnostics;Collection;combat;Communication;Complement;Contact Lenses;Cornea;Corneal Ulcer;cystic fibrosis patients;derepression;design;diagnostic strategy;Disease;Dose;Eye;Eye diseases;Eye Infections;Frequencies;Funding;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genotype;Goals;Growth;Health Personnel;Immune response;Immune system;improved;In Vitro;in vivo;in vivo Model;India;Infection;Inflammation;Inflammatory;innovation;Keratitis;knowledge of results;Laboratories;Link;Lipase;loss of function;Measures;Mission;Modeling;Molecular Genetics;Muramidase;Mus;mutant;Mutation;next generation sequencing;novel strategies;novel therapeutic intervention;ocular surface;Ophthalmologist;Optometrist;Organism;Oryctolagus cuniculus;Outcome;pathogen;Pathogenesis;Pathogenicity;Patient-Focused Outcomes;Patients;personalized medicine;Phenotype;Phylogenetic Analysis;Pilum;Predisposition;prevent;Pseudomonas aeruginosa;Public Health;Publishing;quorum sensing;Reagent;repository;Research;Resistance;Risk;Role;Signal Induction;Source;Steroids;success;targeted sequencing;Testing;Therapeutic;transcription factor;treatment strategy;trend;United States;United States National Institutes of Health;Universities;Up-Regulation;Virulence;Virulence Factors;Virulent;Vision;Visual;whole genome

PROJECT_TITLE: Rise of lasR mutant Pseudomonas aeruginosa keratitis


NIH_SPENDING_CATS: Data Science;Emergency Care;Networking and Information Technology R&D (NITRD);Physical Injury - Accidents and Adverse Effects

ORG_CITY: LITTLE ROCK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE The patient outcomes of Level 1 and Level 2 trauma centers show a surprising variability, given that these organizations have the same clinical specialties and services. We will test which organizational features contribute to this variability by studying 230 Level 1 and Level 2 trauma centers and we will research which organizational characteristics are indicative of the institutional commitment to trauma care. The results will be shared with the participating centers via an innovative, graph-based visualization tool.

PI_NAMEs: BROCHHAUSEN, MATHIAS  (contact);SEXTON, KEVIN WAYNE

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Address;Affect;Age;Architecture;Artificial Intelligence;biomedical informatics;Caring;Cause of Death;Characteristics;Clinical;Clinical Investigator;Communities;Community Healthcare;comparative;Controlled Vocabulary;Data;Data Aggregation;data exploration;data management;Databases;Decision Making;Dependence;Economic Burden;Economics;efficacy outcomes;Environment;Evolution;experience;feasibility testing;Graph;graph knowledge base;Health;implementation science;improved;Individual;Informatics;information organization;innovation;insight;Institution;Intensive Care Units;Knowledge;knowledge base;Knowledge Discovery;Leadership;Length of Stay;medical specialties;Methodology;mortality;novel;Online Systems;Ontology;organizational structure;Outcome;patient variability;Patient-Focused Outcomes;Patients;Pattern;programs;Qualifying;Questionnaires;Research;Research Personnel;Resources;Risk Adjustment;Services;Source;Standardization;Statistical Methods;surgical research;System;Techniques;Terminology;Testing;tool;Trauma;trauma care;trauma centers;Trauma Research;United States;usability;Visual;Visualization;Visualization software

PROJECT_TITLE: Trauma Institutional Priorities and Teams for Outcome Efficacy (TIPTOE)

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nutrition;Orphan Drug;Pediatric;Prevention;Rare Diseases;Social Determinants of Health;Vaccine Related

PHR: PUBLIC HEALTH STATEMENT Prenatal and early life stages are critical periods for development of the immune system, but they are also a crucial time when interventions (such as diet and lifestyle changes) can be implemented effectively. This study will identify how metal exposures, such as from diet or living environments, in prenatal and early life affect child immune function. Findings of our work will motivate pregnancy- and early life-directed interventions that may help millions of children to prevent life-long immune system dysregulation and its related adverse health consequences.

PI_NAMEs: COLICINO, ELENA  (contact);JUSKO, TODD

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: 15 year old;4 year old;5 year old;Adaptive Immune System;Affect;Age;age related;Animals;Antibodies;Antibody Formation;Antibody Repertoire;Antibody Response;Antigens;Arsenic;Attenuated;Attenuated Vaccines;B-Lymphocytes;Bacterial Antigens;Biological Markers;Birth;Blood;Cadmium;causal model;Cell Physiology;Chemical Exposure;Child;Childhood;cohort;critical period;current pandemic;Data;Development;Diet;Diphtheria;Dose;early life exposure;Environment;Environmental Exposure;Environmental Risk Factor;experience;Exposure to;future pandemic;Goals;Growth;Health;heteroplasmy;Immune;immune function;Immune response;Immune system;immune system function;Immunization;Immunologic Memory;Immunosuppression;immunotoxicity;in utero;Individual;individual response;Infection;Innate Immune System;innovation;Intervention;Knowledge;late life;Lead;lead exposure;Lead levels;Life;Life Style;Manganese;Measles;Measures;Mediating;Mediator;Metal exposure;Metals;Mexican;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;Mumps;novel;novel marker;Obesity;oxidative damage;Oxidative Stress;Oxidative Stress Induction;Pertussis;Play;Predisposition;Pregnancy;prenatal;prevent;programs;Public Health;Reactive Oxygen Species;Research;response;Risk;Role;Rubella;Schedule;Second Pregnancy Trimester;social stressor;Somatic Cell;Systems Development;T-Lymphocyte;Tetanus;theories;Time;Tooth structure;Toxoids;Urine;Vaccination;vaccine formulation;vaccine response;Vaccines;Viral Antigens;Work

PROJECT_TITLE: Early-life metal exposures, mitochondrial heteroplasmy, and child antibody response to vaccination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(90)]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The primary purpose of the program is to train the next generation of neuroscientists capable of developing productive research programs and the skills to adapt to changing technologies and new understandings. We are committed to our students’ career development and provide several opportunities for our students to provide them with a strong arsenal of rigorous experimental and analytical training and experience to make them competitive for the increasing opportunities for both non-academic and non-research careers that utilize their scientific and scholarly training.

PI_NAMEs: CZOTY, PAUL W. (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Neurosciences;Training

PROJECT_TITLE: Neuroscience Training at Wake Forest


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Narrative Statement The goal of the proposed research is to introduce a new enabling technology for biomedical imaging and research. This will produce a new and useful assay with broad application in the development of more efficient therapies and for molecular research in autoimmune disorders, stroke, cancer, heart disease and other pathologies.

PI_NAMEs: DIDENKO, VLADIMIR V (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Anti-Inflammatory Agents;Apoptosis;Apoptotic;Autoimmune Diseases;Biological Assay;biomedical imaging;Biomedical Research;Biomedical Technology;cell fixing;Cell Nucleus;cell type;Cells;Cultured Cells;Deoxyribonucleases;design;Detection;Development;DNA;Ensure;Event;Excision;Fluorescence Resonance Energy Transfer;Fluorescent Probes;Genetic;Goals;Heart Diseases;Immunization;immunogenic;Immunohistochemistry;In Situ;In Vitro;Individual;Inflammation;Invaded;Label;Macrophage;Malignant Neoplasms;Methods;Modeling;Molecular;Molecular Target;Necrosis;new technology;Normal tissue morphology;novel;Nuclear;Organism;Pathology;Pathway interactions;Phagocytes;Phagocytosis;Phagolysosome;Process;Proteins;Reaction;Reproducibility;Research;Resolution;Signal Transduction;single molecule;Specificity;Stroke;Systemic Lupus Erythematosus;Technology;technology development;technology validation;tissue fixing;Tissues;Topoisomerase;tumor DNA;viral DNA;Virus Diseases;Visualization

PROJECT_TITLE: FRET detection and in situ quantification of efferocytosis using designed enzymatic activity

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Immunotherapy

ORG_CITY: Aurora

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Immune tolerance is vital in preventing immune dysregulation and autoimmunity. This project describes an anti-inflammatory cytokine, IL-37, critical in maintaining the function of immunosuppressive regulatory T cells (Tregs) in humans. We will investigate the mechanisms of IL-37-induced immune suppression in human Tregs as possible targets for clinical applications.

PI_NAMEs: FUJITA, MAYUMI  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: adaptive immune response;Anti-Inflammatory Agents;Antigens;Applications Grants;Autoimmunity;Binding;Biological;Biology;Blood Cells;CASP1 gene;Cell Line;Cell Nucleus;Cell Physiology;Cell Separation;cell type;Cells;Clinical;clinical application;Clinical Medicine;Complex;cytokine;Data;Dendritic Cells;DNA;exposed human population;Exposure to;extracellular;Failure;Family member;forkhead protein;Foundations;FOXP3 gene;Generations;Genetic Transcription;Graft Rejection;Heterogeneity;Homeostasis;Human;human disease;Human Engineering;humanized mouse;IL2RA gene;Immune;Immune system;Immune Tolerance;Immunosuppression;In Vitro;in vivo;Individual;Inflammasome;Inflammatory;Interleukin-1;Investigation;Laboratory mice;MADH2 gene;MADH3 gene;Maintenance;Mediating;member;Messenger RNA;Molecular;mouse model;Mus;mutant;overexpression;Pathology;Patient Care;peripheral blood;peripheral tolerance;pharmacologic;Phenotype;phenotypic biomarker;prevent;Process;promoter;protein complex;Regulatory T-Lymphocyte;Reporting;Role;Signal Pathway;Species Specificity;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;tissue injury;tool;transcription factor;Transcriptional Regulation;transgene expression;Transgenic Mice;Transgenic Organisms;Translating;translational impact;Translational Regulation;Transplantation;Tumor Immunity

PROJECT_TITLE: The role of IL-37 in human regulatory T cells

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: DE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative Craniofacial defects are among the most common of all congenital abnormalities. An embryonic population of cells called the neural crest gives rise to a significant portion of the craniofacial complex, including bone and cartilage of the face, pigment cells, and components of the peripheral nervous system. My work seeks to understand how a subfamily of transcription factors (SoxE) help the neural crest form the diversity of cell types in the face and how patient specific SOXE mutations cause Campomelic dysplasia and Waardenburg syndrome.

PI_NAMEs: SCHOCK, ELIZABETH (BETSY)  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: ATAC-seq;Biochemical;Biological Models;Biology;bone;Brightfield Microscopy;campomelic dysplasia;career;Cartilage;Cell Culture Techniques;cell type;Cells;Chick;Chimera organism;Chimeric Proteins;ChIP-seq;Chondrogenesis;Chromatin;clinically significant;Collaborations;Computer Analysis;Congenital Abnormality;Coupled;craniofacial;Craniofacial Abnormalities;craniofacial complex;craniofacial development;craniofacial disorder;Data Analyses;Defect;Development;developmental disease;directed differentiation;Disease;disease phenotype;DNA Binding Domain;Dominant-Negative Mutation;Embryo;Environment;Etiology;experience;experimental study;Face;Family;Future;gain of function;Gene Activation;Gene Family;Genes;Genetic Transcription;Genome;Genotype;Global Change;Goals;Heterogeneity;Human;Individual;insight;interest;Lead;Link;loss of function;malformation;Measurable;Mediating;melanocyte;Mentors;migration;model organism;Molecular;Morphology;Mutation;Neural Crest;Neural Crest Cell;neurodevelopment;Neuroglia;Neurons;novel;Patients;Peripheral;Peripheral Nervous System;Phase;Phenotype;Pigments;Play;Population;Postdoctoral Fellow;programs;Proteins;Research;Role;screening;SOX8 gene;Specificity;Stains;stem cell population;Syndrome;Tadpoles;Techniques;Tertiary Protein Structure;Time;transcription factor;transcriptome sequencing;Universities;Variant;Vertebrates;Waardenburg syndrome;Work;work-study;Xenopus;Xenopus laevis

PROJECT_TITLE: The Role of SoxE Transcription Factors in Neural Crest Cell Specialization

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: San Diego

ORG_NAME: EPIGENOME TECHNOLOGIES, INC.

PHR: We proposed to expand our research laboratory into a Paired-Tag services laboratory by developing automated protocols and integrating these with a laboratory information management system. We further proposed to reduce experimental costs by expanding multiplexing and exploring microfluidic single-cell platforms, to make our novel technology easier to use by publishing our processing and analysis pipelines, and to expand our technology’s impact by adapting it to profile transcription factors.

PI_NAMEs: HARTL, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Address;Adoption;analysis pipeline;Antibodies;Architecture;Automation;Bar Codes;Binding;Bioinformatics;Biological;Biological Assay;Biopsy;Cancerous;Cell Nucleus;cell type;Cells;Chemicals;chromatin immunoprecipitation;Chromium;Chromosomes;Collection;combinatorial;Computer software;computerized data processing;Contract Services;cost;crosslink;Custom;Data;Data Analyses;data complexity;Data Set;design;developmental disease;Disease;DNA;DNA Crosslinking;DNA Methylation;DNA-Binding Proteins;Ensure;Epigenetic Process;epigenetic profiling;epigenome;Equipment;experimental study;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Fingerprintings;Genetic Materials;Genetic Transcription;Goals;Heritability;Heterogeneity;histone modification;Hour;human error;Image;improved;Individual;Informatics;Infrastructure;insight;Intestines;Investments;Joints;Laboratories;Laboratory Research;Libraries;Management Information Systems;Manuals;Memory;Methodology;Methods;Microfluidics;Molecular;Monitor;multiple omics;Neurons;new technology;next generation;Nuclear;Organism;Performance;Permeability;Persons;Phase;Population;Preparation;preservation;programs;protein expression;Protocols documentation;Publishing;Reagent;Regulatory Element;relational database;Renal Tissue;Reproducibility;Research;Research Institute;Running;Sampling;Scanning;segregation;Services;Signal Transduction;single cell technology;Small Business Innovation Research Grant;System;Technology;Testing;Tissue Sample;Tissues;Tn5 transposase;tool;transcription factor;transcriptome sequencing;Tube;tumor;tumorigenesis;virtual;web site;Work

PROJECT_TITLE: High-throughput Single Cell Co-assay of Histone Modifications andTranscriptome


NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Estrogen;Immunotherapy;Lymphatic Research;Rare Diseases;Women's Health Research

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: NARRATIVE The outcomes and treatment response of head and neck cancer varies by sex and menopausal status, with premenopausal women demonstrating the best response to therapy, including immunotherapy. Our preclinical data identified regulatory T cells (Tregs), dendritic cells (DCs), and high endothelial venules (HEVs) as target populations mediating estrogen's response to therapy. In this proposal, we examine how estrogen regulates these cellular targets to modulate the sexually dimorphic effect of therapy.

PI_NAMEs: KARAM, SANA D (contact)

PROJECT_TERMS: Adhesions;Affect;Agonist;antagonist;Antigen Presentation;Antigen Presentation Pathway;antigen-specific T cells;Antigens;Autoimmunity;Automobile Driving;Biological;Biological Assay;Biological Markers;Blood;Bone Marrow;cancer cell;cancer therapy;Castration;Cell Cycle Kinetics;Cell Differentiation process;Cell Line;Cell Physiology;Cell Survival;Cells;Cellular biology;cellular targeting;Chimera organism;Circulation;Clinical Trials;Coculture Techniques;Data;Dendritic Cells;density;Dependence;Disease;Dose;draining lymph node;effector T cell;Endosomes;ESR1 gene;Estradiol;Estrogen Receptor 2;Estrogen Receptors;Estrogens;experimental study;Female;Flow Cytometry;FLT3 ligand;Fluorescent Antibody Technique;Genetic;Genetically Engineered Mouse;Goals;Gonadal Steroid Hormones;Head and Neck Cancer;head and neck cancer patient;High Endothelial Venule;Homing;Hormones;Human;Immune;Immune response;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vitro Assay;in vivo;Incidence;Inflammation;Knockout Mice;Label;lymphatic vessel;Lymphocyte;Macrophage;male;Male Castration;Mediating;Mediator;men;menopausal hormone therapy;Menopausal Status;Migration Assay;Modeling;Molecular;mouse model;Mus;Nodal;novel marker;novel therapeutics;Outcome;Ovalbumin;Ovariectomy;pharmacologic;Phenotype;Play;Population;Postmenopause;pre-clinical;Premenopause;Process;programmed cell death protein 1;Proteomics;receptor;Receptor Signaling;Regulatory T-Lymphocyte;Reporting;Research;response;restraint;Risk;Role;Selection for Treatments;sex;Sex Preselection;sex variable;sexual dimorphism;Signal Transduction;Site;System;T cell differentiation;T-Cell Activation;T-Lymphocyte;Target Populations;Testing;Testosterone;Therapeutic;therapy resistant;Time;Toll-like receptors;Tomatoes;trafficking;treatment response;tumor;Tumor Antigens;tumor microenvironment;tumor progression;Up-Regulation;uptake;Woman;women patients

PROJECT_TITLE: Sexual dimorphism and the immuno-modulatory role of estrogen signaling in HNSCC


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Microbiome

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Approximately 30% of all bacterial gene products are microbial “dark matter” and have no known function. To understand what these genes do in both “healthy” bacterial communities and during infections, we need to develop tools that combine classical bacterial genetics with high-throughput computational methods for analyzing large data sets. Developing methods for describing unknown gene function in diverse bacteria will advance the fields of fundamental bacteriology and microbial pathogenesis, helping us to understand our commensal microbiome and driving new approaches to combat the rise of antibiotic resistance.

PI_NAMEs: WILLETT, JULIA  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Advisory Committees;Aftercare;Animals;antagonist;Antibiotic Resistance;Antibiotics;Architecture;Arginine;Automobile Driving;Bacillus subtilis;Bacteremia;Bacteria;bacterial community;Bacterial Genes;bacterial genetics;Bacterial Physiology;Bacterial Proteins;Bacteriology;Basic Science;Biological Models;Biomedical Research;career;career development;chemical genetics;Collaborations;collaborative environment;combat;commensal bacteria;Communities;Complement;Computational Biology;Computing Methodologies;CRISPR interference;dark matter;Data Science;Dental;dental agent;Dental caries;DNA;Dose;drug resistant pathogen;Endocarditis;Enterococcus;Enterococcus faecalis;Escherichia coli;Exposure to;extracellular;fitness;functional genomics;Gene Cluster;gene discovery;gene function;gene product;Genes;Genetic;genome-wide;Genomic approach;Genomics;Goals;Gram-Positive Bacteria;Growth;Guilt;In Vitro;in vitro Model;in vivo;Infection;Institution;interest;Knowledge;large datasets;Libraries;Liquid substance;Measures;Medical;Mentors;Metabolism;Methodology;Methods;Microbe;microbial;Microbial Biofilms;microbial community;microbial products;Microbiology;Minnesota;model organism;Modeling;Molecular;mutant;Nature;novel;novel strategies;oral pathogen;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Pharmaceutical Preparations;Phase;Phenotype;phenotypic data;Pheromone;Polysaccharides;Production;Productivity;professional atmosphere;professor;Public Health;Research;resident commensals;Resistance;Resources;response;Shapes;Streptococcus;Streptococcus mutans;System;Techniques;Technology;tenure track;Testing;tool;Training;transposon sequencing;Universities;Vancomycin Resistance;veterinary science;Virulence;Visualization;Work

PROJECT_TITLE: Functional genomics of hypothetical genes in Gram-positive bacteria

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE To fully unleash the power of spatial barcoding-based transcriptomic data in studying intercellular communications in intact tissue, our research effort will be devoted to developing accurate, robust, and efficient graph learning based approaches for data deconvolution, cell-cell communication network (CCCN) inference, and detecting disease associated CCCN perturbations using spatial transcriptomic data. The ultimate goal is to enhance bioinformatic and computational tools for analysis of spatial transcriptomic data and to advance the understanding of intercellular communication changes in disease for precise therapeutic development.

PI_NAMEs: WANG, ZUOHENG ;YAN, XITING  (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: Address;Algorithms;Attention;autoencoder;Bar Codes;Bioinformatics;bioinformatics tool;Biological Process;Biology;Cell Communication;Cell surface;cell type;Cells;Computer software;computerized tools;Control Groups;Data;Data Analyses;Data Set;design;Diameter;Disease;exosome;experience;Face;generative models;Genes;Genetic;Genetic Transcription;Genomics;Goals;Graph;graph learning;graph neural network;Homeostasis;human tissue;Individual;intercellular communication;Knowledge;Laplacian;Lead;Learning;Ligands;light weight;Location;Measurement;Measures;Methods;Modeling;network models;open source;portability;precision medicine;Pythons;receptor;Research;Research Design;Research Methodology;Research Project Grants;Research Project Summaries;Resolution;Sampling;single-cell RNA sequencing;Slide;spatial integration;Spottings;statistics;study population;System;Technology;therapeutic development;Tight Junctions;Tissues;Training;transcriptome;transcriptomics;Translational Research;Validation;Vesicle

PROJECT_TITLE: Graph Learning of Cell-cell Communications in Spatial Transcriptomics

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: SAN ANTONIO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Alzheimer´s disease (AD) and related disorders (ADRD) disproportionately impacts Hispanics/Latinos, who represent the faster growing segment of the elderly population in the US and particularly in Texas. Building on longstanding strengths in clinical, epidemiological, biomedical, social and behavioral research at the Biggs Institute, University of Texas Health Sciences Center San Antonio (UTHSA) and facilitated by partnership with the University of Texas Rio Grande Valle (UTRGV), the South Texas Alzheimer´s disease Center (STAC) will lead novel precision, personalized medicine approaches to educate, support and improve prevention, treatment and care for patients with ADRD. The Center will serve as a national resource for the design, development, testing and implementation of innovative, pragmatic, effective interventions to diminish the burden of AD in Hispanics.

PI_NAMEs: MAESTRE, GLADYS E.;SESHADRI, SUDHA  (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: Address;Advisory Committees;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Attitude;Autopsy;Behavioral;Behavioral Research;Big Data;biological heterogeneity;Biological Markers;Biology;Blood;Blood Vessels;Brain;Capsicum;Caregiver support;Caregivers;Caring;Clinic;Clinical;Clinical assessments;clinical center;clinical diagnosis;Clinical Informatics;Clinical Research;Clinical Trials;Cognitive;cohort;Collaborations;Collection;Communities;community advisory board;community engagement;Community Health Education;community organizations;Comprehensive Health Care;Consent;cost;Data;Data Collection;data management;Data Set;data sharing;Dementia;dementia risk;design;Development;Diabetes Mellitus;digital;Dimensions;Discipline;Disparity;Doctor of Philosophy;drug development;Drug Targeting;early onset;Education;education research;effective intervention;Elderly;Enrollment;Ensure;Epidemiology;ethnic minority;Ethnic Origin;Exhibits;experience;Face;Faculty;Family;Feces;Fibroblasts;Focus Groups;frailty;Gait;Genetic;Genomics;Geographic Locations;Goals;Grant;Health;health care availability;health care disparity;Health Professional;Health Sciences;Heart;Heterogeneity;Hispanic;Hispanic Americans;Hispanic Populations;Image;improved;improved outcome;induced pluripotent stem cell;Infrastructure;innovation;Institution;Intervention;Interview;Knowledge;Latino Population;Lead;lifestyle factors;Linguistics;lipidomics;Machine Learning;Magnetic Resonance Imaging;Medical Records;Mentors;metabolomics;Methods;Mexican Americans;Minority;Molecular;molecular phenotype;Motor;multidisciplinary;multiple omics;Music;Names;Nerve Degeneration;Neurology;neuropathology;Neurosciences;novel;outreach;Pathologic;Pathology;Patient Care;patient engagement;Patients;Peripheral Blood Mononuclear Cell;personalized medicine;Persons;Phenotype;Plasma;Population;population health;Positron-Emission Tomography;pragmatic implementation;pre-clinical;precision medicine;preference;Prevention;Printing;Privatization;Process;Proteomics;Public Health;Race;Radio;recruit;Research;Research Personnel;Research Priority;resilience;Resources;Retina;risk prediction;Saliva;Sampling;Science;Sensory;Series;Serum;Services;Site;Skin;social;socioeconomics;South Texas;Spinal Cord;Statistical Methods;Subgroup;Testing;Texas;Time;Tissues;Training;Twitter;Underrepresented Minority;Universities;Urine;Vocational Guidance;web site;Woman

PROJECT_TITLE: South Texas Alzheimer's Disease Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Rural Health

PI_NAMEs: SESHADRI, SUDHA  (contact)

PROJECT_TERMS: Address;Administrative Efficiency;Advisory Committees;Affect;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's Disease Core Center;Alzheimer's disease related dementia;Behavioral;Career Mobility;Clinical Investigator;Collaborations;Communication;Communities;community engagement;Community Health Education;Contracts;Data;Data Coordinating Center;data sharing;data storage site;developmental disease;Diagnosis;Disease;Diverse Workforce;Education;education research;Elderly;Ensure;Environment;environmental enrichment for laboratory animals;Etiology;experience;Faculty;Family;Fostering;Foundations;Funding;Genetic;Goals;Grant;health care delivery;health disparity;Health Sciences;Hispanic ancestry;Hispanic Populations;Human Resources;human subject;improved;Infrastructure;innovation;Institution;International;Lead;Leadership;Logistics;Maintenance;meetings;member;Minority Participation;Mission;National Institute on Aging;Neurosciences;novel;older adult;Pathogenesis;Policies;Population Heterogeneity;public-private partnership;recruit;Reduce health disparities;repository;Research;Research Personnel;research study;Resource Sharing;Resources;Science;Scientist;Seasons;Site;South Texas;Strategic Planning;synergism;Texas;Training;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: South Texas Alzheimer's Disease Center Administrative Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Orphan Drug;Precision Medicine;Rare Diseases;Urologic Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative Urothelial carcinoma is understudied despite being the 6th most common cancer in the US. Outcomes for localized, muscle-invasive urothelial carcinoma are unsatisfactory with the current standard of care of neoadjuvant chemotherapy followed by radical cystectomy. This project will characterize the immune infiltrate before and after neoadjuvant therapy and will develop predictive biomarkers to ultimately design novel, more effective, personalized regimens to improve survival.

PI_NAMEs: COLLIER, KATHARINE A. (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Achievement;Address;Adjuvant Chemotherapy;Affect;Aftercare;Award;Biological Assay;biomarker development;biomarker driven;biomarker performance;biomarker validation;Bladder;Bladder Neoplasm;career development;CD8-Positive T-Lymphocytes;CD8B1 gene;Chemical Engineering;chemotherapy;Cisplatin;Clinical;clinical training;Clinical Trials;Clinical Trials Design;cohort;Complement;Comprehensive Cancer Center;Cystectomy;Data;Data Analyses;design;differential expression;Disease;Doctor of Philosophy;Ensure;Environment;Excision;experience;FOXP3 gene;Future;gemcitabine;Gene Expression Profile;Genes;Goals;Grant;high dimensionality;Immune;immune cell infiltrate;Immune checkpoint inhibitor;improved;improved outcome;In complete remission;Individual;Institution;Investigation;Investments;Knowledge;Leadership;Malignant Neoplasms;Measures;Medical Oncology;Mentors;Mentorship;Methods;Modernization;Molecular Analysis;multiple omics;Muscle;Neoadjuvant Therapy;novel;Ohio;Outcome;overtreatment;Pathologic;Patient Selection;Patient-Focused Outcomes;Patients;Performance;Perioperative;Phase II Clinical Trials;phase II trial;Physicians;preclinical study;Preclinical Testing;predictive marker;prevent;prospective;protein expression;Proteins;Proteomics;Radical Cystectomy;rational design;Regimen;Regulatory T-Lymphocyte;Research;research and development;Residual Neoplasm;Resources;responders and non-responders;response;response biomarker;Sampling;Scientist;skills;Specimen;standard of care;Stromal Cells;Systemic Therapy;T cell infiltration;Techniques;therapy resistant;Time;Tissue Sample;Tissue-Specific Gene Expression;Tissues;Training;transcriptomics;Transitional Cell Carcinoma;translational physician;translational scientist;Treatment Protocols;treatment response;treatment stratification;tumor;tumor immunology;tumor microenvironment;Tumor-infiltrating immune cells;Universities;Urethra;Urogenital Cancer;Writing

PROJECT_TITLE: Characterizing the immune infiltrate in muscle-invasive urothelial carcinoma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

PHR: Project Narrative In order to reduce the incidence of HIV in Kazakhstan, improve surveillance, and better monitor drug resistance to enable appropriate therapy, we propose this Fogarty training grant: Molecular Virology and Epidemiology in Kazakhstan (MoVE-Kaz). A partnership of key Kazakh institutions, supported by U.S. and Belgian universities, 12 early career scientists and clinicians will be trained in molecular epidemiology and HIV disease control and prevention.

PI_NAMEs: ALI, SYED ;VERMUND, STEN H. (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Belgium;Central Asia;cohort;Collaborations;Communities;Data;Drug resistance;Eastern Europe;Emerging infection;Epidemic;Epidemiology;epidemiology study;Ethics;experience;Faculty;Funding;Grant;hands on research;Harm Reduction;Health Professional;high risk;HIV;HIV Infections;improved;indexing;Individual;Infection;International;Intervention;Kazakhstan;Knowledge;Link;Mentors;Molecular Epidemiology;Molecular Virology;National Institute of Drug Abuse;Patient Care;Persons;Phylogenetic Analysis;Physicians;Population;programs;Public Health;Research;Scientist;Services;skills;tool;Training;Training Programs;transmission process;Universities;Variant;Viral;viral transmission

PROJECT_TITLE: Molecular Virology/Epidemiology HIV Training in Kazakhstan (MoVE-Kaz)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(56)]


NIH_SPENDING_CATS: Cancer;Genetics;Infectious Diseases;Rare Diseases;Skin Cancer

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project narrative Merkel cell polyomavirus (MCPyV) can cause one of the most aggressive skin cancers, Merkel cell carcinoma (MCC). This proposal seeks to investigate the largely unknown mechanism of MCPyV early gene transcription, which drives MCPyV infection and MCC tumorigenesis. The findings obtained from these studies may facilitate the development of virus-targeted novel therapeutic strategy for treating the highly lethal MCC cancer, which contributes significantly to HIV/AIDS-associated malignancies.

PI_NAMEs: YOU, JIANXIN  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: AIDS related cancer;Automobile Driving;Binding;Binding Sites;Bioinformatics;Cancer Etiology;cancer genome;carcinogenesis;Cell Death;cell type;Cells;Cellular Tropism;Chemicals;ChIP-seq;chronic infection;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;COVID-19 vaccine;CRISPR screen;Death Rate;Dermal;Development;DNA;Early Gene Transcriptions;Early Promoters;effective therapy;Elements;Enhancers;Environment;Epigenetic Process;experimental study;Fibroblasts;Gene Expression;Genes;Genetic;genetic analysis;Genetic Transcription;Genome;Goals;Guide RNA;Histones;HIV;Human;Immunocompromised Host;Immunosuppression;improved;In Situ;In Vitro;in vivo;Incidence;Individual;Infection;Infectious Skin Diseases;inhibitor;insight;Investigation;Knock-out;Knowledge;laser capture microdissection;Life Cycle Stages;lipid nanoparticle;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;Merkel cell carcinoma;Merkel Cells;Modeling;Modification;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Nucleosomes;Oncogenes;Oncogenic;Oncogenic Viruses;Patients;permissiveness;Physiological;Play;Polyomavirus;Polyomavirus Infections;prevent;Process;Property;Proteomics;Publishing;Reader;recruit;Reporter;Risk Factors;Role;screening;Skin;Skin Cancer;Small T Antigen;Study models;success;System;Technology;Therapeutic;Tissues;tool;transcription factor;Translating;Tropism;tumor growth;tumorigenesis;tumorigenic;Viral;viral DNA;Viral Oncogene;virology;Virus;virus development;Virus Diseases;Xenograft procedure

PROJECT_TITLE: Targeting MCPyV oncogene transcription to suppress tumorigenesis

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;HIV/AIDS;Hypertension;Neurosciences;Nutrition;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Salt taste sensitivity is a driver of salt intake and therefore likely to increase the risk of developing hypertension especially among persons with HIV where the risk is heightened. Genetic association studies in this area are limited with more research needed in populations of different ethnic backgrounds, such as African populations. The goal of this study is to explore the link between salt taste sensitivity and salt intake, blood pressure, hypertension and genetic variations in the taste receptor gene of ENaC in individuals of African descent.

PI_NAMEs: KIRABO, ANNET  (contact);MASENGA, SEPISO KENIAS

PROJECT_TERMS: Address;Adult;Affect;Africa;Africa South of the Sahara;African;African ancestry;Age;Applications Grants;Area;arterial stiffness;Automobile Driving;biobank;Biological Markers;Blood Pressure;blood pressure elevation;Blood specimen;Cardiovascular Diseases;Cardiovascular system;Cessation of life;cohort;Consumption;Country;Data;Development;Diet Habits;Dietary Assessment;dietary salt;disorder prevention;Enzyme-Linked Immunosorbent Assay;epithelial Na+ channel;Ethnic Origin;European;Exhibits;Flow Cytometry;Food;Future;gene product;Genetic;genetic association;genetic linkage;Genetic Polymorphism;Genetic Predisposition to Disease;Genetic Risk;Genetic study;genetic variant;Genetic Variation;Genomics;Genotype;Goals;high body mass index;high risk population;HIV;HIV risk;HIV Seronegativity;Hour;Hypertension;IL17 gene;immune activation;Individual;Inflammation;Inflammatory;inflammatory marker;insight;Interferon Type II;Interleukin-6;Intervention Studies;Kidney Diseases;Laboratories;Life Style;Link;Literature;low and middle-income countries;Measures;metabolomics;Myocardial Infarction;normotensive;Participant;Pathogenesis;Pathologic;Pathway interactions;Perception;Persons;Population;preference;Prevalence;Proteomics;Receptor Gene;Recommendation;recruit;Research;response;Risk;Risk Factors;saliva sample;salt intake;salt sensitive hypertension;Sodium Chloride;Stroke;Taste Buds;Taste Perception;Testing;Tongue;Urine;Vascular Diseases;World Health Organization;Zambia

PROJECT_TITLE: Salt taste sensitivity, genetics and salt sensitivity of blood pressure in HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: WHITE, CAROLE LEONE (contact)

PROJECT_TERMS: Address;Adoption;Adult;Advocate;Affect;Aging;Alzheimer's Disease;Alzheimer's Disease Core Center;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Behavioral Research;Biomedical Research;Caregiver support;Caregivers;Caring;Clinical;Clinical Trials;Communication;Communities;community academic partnership;community advisory board;community based research;community engagement;community involvement;community organizations;Consolidated Framework for Implementation Research;Country;Department chair;Disease;dissemination research;distrust;Doctor of Philosophy;Early Diagnosis;Education;Elderly;Environment;ethnic diversity;experience;Family;Family Practice;Feedback;Focus Groups;Frail Elderly;Geographic Locations;Geriatrics;Goals;Health;health disparity;Health Personnel;Health Sciences;Hispanic;Hispanic Populations;human old age (65+);implementation science;improved;Infrastructure;Institution;interest;Interview;Knowledge;Leadership;Locales;member;Mexico;Minority;Neurodegenerative Disorders;older adult;outreach;Palliative Care;Participant;participant retention;Patients;Physicians;Policy Maker;Population;population health;Population Heterogeneity;Positioning Attribute;Process;programs;Race;recruit;Reduce health disparities;Research;Research Personnel;research study;Resources;rural Hispanic;Scientific Advances and Accomplishments;Scientist;Services;social;social stigma;South Texas;Surveys;System;Texas;Training;Translating;Underrepresented Populations;Underserved Population;Universities;Work

PROJECT_TITLE: South Texas Alzheimer’s Disease Center Outreach, Recruitment and Engagement Core


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: RICHARDSON

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: PROJECT NARRATIVE Language disorders affect millions of people in the United States. There is an extensive research community, with much of this research funded by the NIH, principally NIDCD, but also NINDS, NICHD-NCMRR, and NIA, that targets both basic and clinically-oriented research on the neurobiological basis of language and language disorders. By providing a forum for the communication of new research findings and emerging trends, the Annual Meeting of the Society for the Neurobiology of Language will play a pivotal role in scientific progress aimed at understanding, diagnosing, and treating language disorders.

PI_NAMEs: SMALL, STEVEN L (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Academy;Address;Adult;Affect;Ally;Anatomy;Aphasia;Area;Award;Behavior;Biological;Biological Response Modifier Therapy;Brain;brain behavior;Brain Mapping;care systems;career;career development;Chicago;Child;Child Care;Clinical;clinical application;Cognitive;cognitive neuroscience;Collaborations;Collection;Communication;Communication impairment;Communities;Comprehension;Computers;COVID-19 pandemic;Data;Development;Devices;Diagnosis;Discipline;Drug Targeting;Education;Educational workshop;Financial Support;functional improvement;Funding;Genetic;Goals;Grant;hearing impairment;Human;innovation;insight;Interdisciplinary Education;interest;Knowledge;Language;Language Disorders;language impairment;Language Pathology;Lesion;Light;Linguistics;Link;Mathematics;Measurement;meetings;member;Modeling;motor control;National Institute of Child Health and Human Development;National Institute of Neurological Disorders and Stroke;National Institute on Deafness and Other Communication Disorders;neural;neural circuit;neurobiological mechanism;Neurobiology;Neurologist;Neurology;Neurosciences;Neurosciences Research;neurosurgery;novel;Parents;Participant;Performance;Persons;Physics;Physiological;Physiology;Play;Postdoctoral Fellow;Production;programs;Psychiatry;Psycholinguistics;Psychology;reduce symptoms;Research;Research Personnel;Resolution;Role;Scholarship;Scientist;Seminal;Services;Shapes;Societies;Speech;Students;success;Suggestion;Surveys;symposium;Technology;Time;Training;Training and Education;Translations;Travel;trend;Underrepresented Populations;United States;United States National Institutes of Health;virtual;Woman;Work

PROJECT_TITLE: Society for the Neurobiology of Language Annual Meeting

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE A major barrier to decoding the human genome is a lack of maps, models and tools to understand how transcriptional control sequences are spatially and temporally organized in the nucleus to regulate gene expression. The proposed research will address this pressing need by deploying transformative technologies to produce navigable reference maps and predictive structural models for diverse cell types in the mammalian brain. The results could facilitate the functional annotation of the human genome and improve our understanding of the genetic basis of a variety of neurological diseases.

PI_NAMEs: DULAC, CATHERINE ;LEIN, ED ;NICODEMI, MARIO ;POMBO, ANA ;REN, BING  (contact);WANG, TING ;ZHUANG, XIAOWEI

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: 3-Dimensional;Acute;Affect;analytical tool;Architecture;Atlases;Biological;Biological Assay;Brain;Brain region;cell cortex;Cell Nucleus;cell type;Cells;Chromatin;Chromatin Modeling;Chromatin Structure;cohesin;Communication;Communities;Complex;CRISPR interference;Data;Development;Distal;Elements;embryonic stem cell;Enhancers;epigenome;epigenomics;experimental study;Free Will;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genome;Genome Mappings;genomic data;Genomics;Goals;high resolution imaging;Hippocampus;Human;Human Genome;Hypothalamic structure;Image;Imaging Device;improved;Individual;informatics tool;insight;invention;Knowledge;learning strategy;Macaca;Mammalian Cell;mammalian genome;Mammals;Maps;Measurable;Methods;Modeling;Monkeys;Mouse Embryonic Stem Cells;multimodality;Mus;nanoscale;nerve stem cell;Nervous System Disorder;neural circuit;new technology;Nuclear;Physics;Physiological;Play;Polymers;predictive modeling;programs;promoter;Regulator Genes;Research;Research Personnel;Research Project Grants;Resolution;Role;Scientist;single cell genomics;Slice;Social Behavior;statistical learning;Structural Models;Structure;Technology;Testing;Tissues;tool;Transcriptional Regulation;transcriptomics;Untranslated RNA;Virtual and Augmented reality;virtual reality;Visualization;Visualization software;web portal

PROJECT_TITLE: Center for Integrated Multi-modal and Multi-scale Nucleome Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(50)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Precision Medicine;Rural Health

PI_NAMEs: HAN, XIANLIN  (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Basic Science;biobank;Biochemical;Biological Assay;Biological Markers;Biology;biomarker development;biomarker identification;Blood;Brain;Capsicum;Caring;Catalogs;Cerebrovascular Trauma;Clinical;clinical center;clinical diagnosis;Clinical Research;Clinical Trials;Cognition;cohort;Collaborations;Collection;Communication;Communities;Data;data management;Dementia;Development;Diagnosis;Differential Diagnosis;Disease;disease heterogeneity;disorder subtype;DNA;Doctor of Philosophy;Early Diagnosis;Endothelium;Enrollment;Exclusion Criteria;Feces;flexibility;fluorodeoxyglucose positron emission tomography;follow-up;Functional disorder;Funding;genomic data;Genomics;Goals;Grant;Heterogeneity;Hispanic;Hispanic Populations;Image;improved;Individual;inflammatory marker;insight;International;Link;lipidomics;Magnetic Resonance Imaging;Measures;Metabolic;metabolomics;Methods;Molecular;monocyte;Motor;multiple omics;Nerve Degeneration;neurodegenerative dementia;neuropathology;Neurosciences;Non-Insulin-Dependent Diabetes Mellitus;normal aging;novel;novel marker;Onset of illness;Participant;Patient Recruitments;Patients;Pattern;peripheral blood;personalized medicine;Persons;Plasma;Population;Positron-Emission Tomography;pre-clinical;Prevalence;Procedures;Process;prodromal Alzheimer's disease;prognostication;Protocols documentation;repository;Research Personnel;research study;Resources;risk prediction;RNA;Saliva;Sampling;Sensory;Serum;Services;South Texas;Special needs;symposium;System;Time;Translational Research;Visit;Work

PROJECT_TITLE: South Texas Alzheimer’s Disease Center Biomarker Core


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: NARRATIVE mTORC1 is a major driver of cancer and an established anticancer drug target. This application will test the central hypothesis that nuclear mTORC1 signaling is critical for promoting cancer metabolism, tumorigenesis and mTORC1-targeted therapy.

PI_NAMEs: ZHENG, STEVEN  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: aerobic glycolysis;anti-cancer;Antineoplastic Agents;Biogenesis;cancer cell;CCI-779;cell growth;Clinical;Data;Drug Targeting;Event;FDA approved;Genes;Genetic Transcription;Growth;Human;improved outcome;inhibitor;insight;Malignant Neoplasms;Mediating;Metabolic;Metabolic Control;Metabolism;mRNA Precursor;Mutate;Nuclear;Nutrient;Oncogenic;Oncology;Oxidative Phosphorylation;Oxygen;Pathway interactions;Pharmaceutical Preparations;polymerization;Polymers;Process;Regulation;Repression;response;RNA Splicing;RNA-Binding Proteins;Signal Transduction;Sirolimus;Stimulus;Structure;targeted treatment;Testing;treatment response;tumor metabolism;tumorigenesis;tumorigenic;Untranslated RNA;Warburg Effect

PROJECT_TITLE: Metabolic Control and Anticancer Mechanism

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Clinical Research;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Sepsis

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: Project Narrative This project will contribute to the field by creating small volume sample collection, processing, and storage practices that are rigorous, reproducible, and validated for use in multi-omic studies. We will use machine learning methods to develop new models of neonatal sepsis from stool, blood, skin, and saliva for detection, differential diagnoses, and/or prediction of systemic inflammatory to infection. Our multi-omic network will establish molecular targets (pathways, genes, and metabolites) for future experimental studies to validate proposed causal mechanisms in sepsis progression and recovery.

PI_NAMEs: PRESCOTT, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Achievement;Adult;Age;Antibiotics;Apgar Score;Bacterial Infections;Biological;Biometry;Birth;Birth Weight;Blood;Blood Transfusion;Body mass index;Cause of Death;Clinical;Clinical Data;clinical research site;Collection;Communicable Diseases;Computer Analysis;Critical Illness;Data;Delivery Rooms;Detection;Development;Diagnosis;Diet;Differential Diagnosis;differential expression;Disease;Documentation;Ensure;Environment;Ethnic Origin;Event;experimental study;extreme prematurity;Feces;Foundations;Functional disorder;Future;gene interaction;gene network;Genes;Gestational Age;Growth;Head circumference;Heterogeneity;high risk population;Hospitals;Hour;Human;Image;Immune response;Immunologist;Incidence;Infant;Infection;Inflammatory;Intake;Length;Life;Life Style;Low Birth Weight Infant;Machine Learning;machine learning method;Medical;Methods;microbial;microbiome;Modeling;molecular modeling;Molecular Target;multiple omics;Mycoses;Neonatal;Neonatal Intensive Care Units;neonatal sepsis;neonate;Organ;Outcome;Output;Pathway Analysis;Pathway interactions;Patients;Performance;Pharmaceutical Preparations;Phase;Physiology;Population;Positioning Attribute;predictive marker;predictive modeling;Pregnancy;premature;Premature Infant;preservation;Procedures;Protocols documentation;Provider;Race;Recovery;Rectum;Reproducibility;Research;Resolution;respiratory;Resuscitation;Saliva;sample collection;Sample Size;Sampling;Science;Sepsis;Serum;sex;Site;Skin;Specialist;Specimen;Spottings;Staging;standard of care;Standardization;Stratification;Support System;Swab;System;Techniques;Technology;Testing;Time;Tissues;treatment response;Tube;Urine;validation studies;Very Low Birth Weight Infant;Virus Diseases

PROJECT_TITLE: The Scientific Value of Premature Infant Biospecimens Collection

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: SATIZABAL, CLAUDIA L (contact)

PROJECT_TERMS: Address;aging brain;Agreement;Alzheimer's Disease;Alzheimer's Disease Core Center;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Assessment tool;Behavioral;Bioinformatics;Biological Markers;Biology;Blood;Brain imaging;cardiovascular risk factor;Chemicals;Clinical;Cognitive;cognitive testing;cohort;Collaborations;Communities;Consultations;cost effective;critical period;Data;data harmonization;data integration;data management;data resource;data sharing;Dementia;dementia burden;Diabetes Mellitus;Disease;disorder risk;Disparity;disparity reduction;Doctor of Philosophy;Education;education research;epidemiology study;epigenome;ethnic minority population;Etiology;Face;Genome;Genomics;Goals;health disparity;Health trends;high risk;Hispanic Americans;hispanic community;Hispanic Populations;Image;Impaired cognition;improved;Incidence;innovation;insight;International;Knowledge;Life Cycle Stages;Life Style;Linguistics;lipidome;Liquid substance;Magnetic Resonance Imaging;metabolome;Methods;Mexican Americans;microbiome;modifiable risk;Monitor;neuropathology;Neurosciences;Neurosciences Research;novel;Phenotype;Population;population based;Population Research;Population Study;Positioning Attribute;Positron-Emission Tomography;precision medicine;Prevalence;prevent;Preventive measure;Process;protective factors;Proteome;Protocols documentation;psychosocial;Public Health;Qualitative Research;racial minority population;Recommendation;Reduce health disparities;Research;Research Methodology;Research Personnel;resilience factor;Resource Sharing;Resources;Risk Factors;risk prediction;Role;Services;skills;Source;South Texas;statistics;tool;Training;transcriptome;wearable device

PROJECT_TITLE: South Texas Alzheimer’s Disease Center Population Neuroscience


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Rural Health

PI_NAMEs: FOX, PETER THORNTON (contact)

PROJECT_TERMS: Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Animals;Architecture;Archives;Arts;Autopsy;Biochemistry;Biological Markers;Biomedical Research;Blood Chemical Analysis;Brain;brain magnetic resonance imaging;burden of illness;Capital;Categories;Clinical;clinical care;clinical center;Clinical Trials;cluster computing;Collaborations;Communities;Computers;Cyclic GMP;Cyclotrons;Data;data management;data sharing;Dedications;Degree program;Development;Diagnostic radiologic examination;Doctor of Philosophy;Doctor's Degree;Education;education research;Equipment;Etiology;Excision;experience;Faculty;faculty mentor;Faculty Recruitment;FDA approved;Fostering;Functional Magnetic Resonance Imaging;Generations;Genetic;genetic pedigree;GENIE;Goals;graduate student;Grant;graph theory;hemodynamics;High Performance Computing;Hispanic Populations;Home;Human;human imaging;Image;Image Analysis;image archival system;image guided;imaging facilities;imaging modality;imaging program;informatics infrastructure;Infrastructure;instrument;instrumentation;International;Ions;Isotopes;K-Series Research Career Programs;Laboratories;Licensing;Machine Learning;Magnetic Resonance Imaging;Measures;Medical;Medical Imaging;Metabolism;Methods;Mission;Morphologic artifacts;Motion;MRI Scans;multi-site trial;multimodality;multiple omics;network models;neuroimaging;neuropathology;Neurosciences;novel;Nuclear Pore Complex;Performance;Physicians;Physiologic pulse;Play;Population;Positron-Emission Tomography;Postdoctoral Fellow;Production;programs;protocol development;Protocols documentation;Psychometrics;Publications;Quality Control;Radiochemistry;Radiology Specialty;Radiopharmaceuticals;receptor density;recruit;Research;research facility;Research Institute;Research Training;Resources;response;RF coil;Robotics;Role;Scanning;Science;Scientist;Services;Site;South Texas;Spectrum Analysis;Standardization;Statistical Data Interpretation;statistical learning;statistics;Stimulus;Structure;System;tau Proteins;Texas;Training;Training Programs;Training Support;Transcranial magnetic stimulation;trial design;Validation;virtual;web interface;Work

PROJECT_TITLE: South Texas Alzheimer's Disease Center Imaging Core