NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Epstein-Barr virus establishes latent infection in lymphoid tissue in the oral cavity. These studies will define the molecular mechanisms underlying latency establishment and recurrence.

PI_NAMEs: LUFTIG, MICAH A. (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Adolescence;Adult;Apoptotic;Architecture;B lymphocyte immortalization;B-Cell Activation;B-Lymphocytes;BAG3 gene;Benign;Biochemical;Biological;Biology;Cell Differentiation process;Cell Fate Control;cell immortalization;Cell Lineage;Cell Maturation;Cell Survival;Cells;Cellular Metabolic Process;Chromatin;Data;Epithelial Cells;Epstein-Barr Virus latency;Gene Expression;Genes;Genetic Transcription;Goals;Herpesviridae;Human;Human Herpesvirus 4;Immune;Immunoglobulin Class Switching;Immunoglobulin-Secreting Cells;in vivo;Individual;Infection;Infectious Mononucleosis;insight;latent infection;Latent virus infection phase;Life Cycle Stages;Link;Lymphoid Tissue;Lytic;Lytic Virus;Malignant Neoplasms;MCL1 gene;Mediating;Memory;Memory B-Lymphocyte;mimicry;Mitochondria;Modality;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;NFKB2 gene;novel;Oral;Oral cavity;peripheral blood;Phenotype;plasma cell differentiation;Plasma Cells;Plasmablast;PRDM1 gene;Primary Infection;Productivity;programs;Proliferating;Proteins;Reaction;reactivation from latency;recruit;Recurrence;Regulation;Research;Rest;Saliva;Sampling;Signal Transduction;single-cell RNA sequencing;Structure of germinal center of lymph node;Testing;Therapeutic;Tonsil;transcription factor;transmission process;Viral;Viral Genes;Viral Load result;Virion;virtual;Virus;XBP1 gene;YY1 Transcription Factor

PROJECT_TITLE: Defining the Mechanisms of Epstein-Barr Virus Persistence and Recurrence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-W(02)M]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: JACKSONVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: The purpose of this study is to test the novel hypothesis that glia-specific purinergic receptor P2RX7 mediate the secretion of small extracellular vesicles for mediating the spread of tau pathology from cells to cells. Here we propose to validate our exciting preliminary study with genetically targeted mouse model of P2RX7 by neuropathology, behavioral testing, and in vitro cell models. We will also determine which cell types are responsible for the P2RX7-mediated disease spread in this study, which would have direct translational implication for the prevention or treatment of Alzheimer's disease.

PI_NAMEs: IKEZU, TSUNEYA  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Acceleration;Age;Age Months;Alzheimer's Disease;Alzheimer's disease model;Anatomy;Animal Model;Astrocytes;behavior test;behavioral phenotyping;Brain;Brain Diseases;Brain region;Cations;Cell model;cell type;Cells;Clinical;comparison control;Complex;Cre driver;Data;Dependovirus;Development;Disease;Endosomes;Enzyme-Linked Immunosorbent Assay;exosome;experimental study;extracellular vesicles;feeding;Genetic;Goals;hippocampal pyramidal neuron;Hippocampus;hyperphosphorylated tau;In Vitro;in vivo;in vivo Model;Incubated;Inflammatory;inhibitor;LoxP-flanked allele;Maps;Mediating;Microglia;microvesicles;Molecular;mouse model;multi-electrode arrays;Mus;Neurofibrillary Tangles;Neuroglia;Neurons;neuropathology;neurotoxicity;novel;Pathologic;Pathology;Pattern;Phagocytosis;pharmacologic;prevent;Prevention;Process;protein aggregation;Proteins;Purinoceptor;Series;Signal Pathway;Sorting;Source;Specificity;Symptoms;System;tau aggregation;tau expression;tau mutation;tau Proteins;Tauopathies;Testing;Therapeutic;trafficking;TSG101 gene;uptake

PROJECT_TITLE: Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's disease


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: We introduce a new concept regarding how the effects of growth factors are regulated. Detailed studies of this novel mechanism advance fundamental knowledge and may lead to the development of novel therapeutics for diseases such as ischemic heart disease and cancer.

PI_NAMEs: SADEGHI, MEHRAN M (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Address;Adult;Affinity;Amino Acids;angiogenesis;Area;Base Sequence;Binding;Biology;Blood Vessels;C-terminal;cadherin 5;Cardiovascular Diseases;Cells;Cellular biology;Charge;Complex;Cultured Cells;Development;Diabetic Retinopathy;Disease;drug development;Endothelial Cells;Endothelium;Ensure;experimental study;Future;Growth;Growth Factor;Homeostasis;Hydrophobicity;in vivo;Integral Membrane Protein;interest;Ischemia;KDR gene;Knowledge;Learning;Length;Location;Lower Organism;Malignant Neoplasms;Mediating;Molecular;mouse model;Myocardial Ischemia;N-terminal;Names;Neuropilins;novel;novel therapeutics;Pathologic;Peptide Signal Sequences;Peptides;Play;Process;Protein Tyrosine Phosphatase;Proteins;prototype;receptor;Receptor Protein-Tyrosine Kinases;Regulation;Reporting;response;response to injury;Role;Signal Pathway;signal peptidase;Signal Transduction;Site;Smooth Muscle Myocytes;Specificity;Structure;synthetic peptide;Therapeutic;Time;Translating;uptake;Vascular Endothelial Growth Factors;wound healing

PROJECT_TITLE: Signal peptides and growth factor signaling

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Transplantation

ORG_CITY: ATLANTA

ORG_DEPT: SURGERY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative Blockade of CD154 is a highly effective method of inducing transplantation tolerance (a state in which transplant recipients would no longer require toxic immunosuppression), however clinical translation of CD154 blockers has met with many challenges, and as an alternative reagents that block CD40 (the receptor for CD154) are now in the clinical pipeline. However, CD40 blockers are not as effective as CD154 blockers, and here we have identified a novel molecular interaction that explains this discrepancy. Mechanistic understanding of this new molecular interaction is of the utmost importance in order to devise innovative strategies to block these residual interactions and thus optimize the use of CD40 blockers in the clinic.

PI_NAMEs: FORD, MANDY L (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acceleration;Address;Adhesions;Affinity;allograft rejection;Allografting;Alternative Therapies;antagonist;Anti-CD40;Antibodies;Binding;Binding Sites;Biological;Biological Assay;Blood Platelets;CD8-Positive T-Lymphocytes;cell motility;Chemotactic Factors;Clinic;Clinical;clinical development;Clinical Research;clinical translation;clinically relevant;Communication;crosslink;Data;early phase clinical trial;Event;Experimental Models;experimental study;FOXP3 gene;Frequencies;Generations;Hemostatic Agents;Human;Immunosuppression;in vivo;Infiltration;Inflammation;innovation;isoimmunity;ITGAM gene;Leukocytes;Mediating;Mediator;Methods;migration;Modeling;Monoclonal Antibodies;monocyte;Mus;Myeloid Cells;Nature;nonhuman primate;novel;Outcome;Paper;Pathway interactions;Peptides;Phase;pre-clinical;preclinical study;prevent;Primates;Reagent;receptor;Reporting;Residual state;Role;Safety;Signal Transduction;Solid;Source;Surface Plasmon Resonance;T cell infiltration;T cell response;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Thromboembolism;TNFRSF5 gene;TNFSF5 gene;trafficking;Transplant Recipients;Transplantation;Transplantation Tolerance

PROJECT_TITLE: CD11b:  A Novel Alternate Receptor for CD154 during Alloimmunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-F(02)M]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Childhood Leukemia;Clinical Research;Hematology;Mental Health;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Findings from this study may ultimately enable providers in pediatric oncology to discern, via simple pen-and- paper screening, information about a child's immune response to stress and related risk for psychosocial or neurocognitive deficits linked to impairment in emotion regulation. In this way, both psychosocial interventions targeted at improving emotion regulation or neurocognition could be combined with immune-targeted pharmacological interventions in a true model of child-centered precision medicine. Given that eventual long- term survivorship is anticipated for more than 85% of pediatric oncology patients, understanding the nature and long-term psychological and biological impact of stress in pediatric cancer is critical for enabling maximal quality of life into young adulthood and beyond.

PI_NAMEs: COSGROVE, VICTORIA EILEEN (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Adolescence;Adolescent;Adult;Adverse event;Advisory Committees;Affect;Affective;Asthma;Award;Biological;biological adaptation to stress;Biological Markers;Biology;Biometry;Blood;Brain;Brain region;cancer therapy;Cardiovascular Diseases;Child;Child Psychology;Childhood;Chronic Disease;Clinical Research;cohesion;Complex;cytokine;Decision Making;Development;Diagnosis;Doctor of Medicine;Doctor of Philosophy;Down-Regulation;emotion regulation;Emotional;Emotions;Ethics;executive function;Family;Feedback;follow-up;Foundations;Glucocorticoids;Goals;Grant Review;Hormones;Hospitalization;Hydrocortisone;Immune;Immune response;Immune system;immune system function;Immune Targeting;Impairment;improved;Inflammation;Inflammatory;Intervention;Life Experience;Link;Long Term Survivorship;Longitudinal Studies;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of central nervous system;Malignant Neoplasms;Manuscripts;Measurement;Mediating;Medical;Mental disorders;Mental Health;Mental Health Services;mental set;Mentorship;Modeling;Moods;National Cancer Institute;Nature;Neurocognition;Neurocognitive;Neurocognitive Deficit;Oncology;Outcome;Paper;Patients;Pediatric Oncology;Peer Review;perceived stress;pharmacologic;physical conditioning;precision medicine;programs;protective factors;Provider;psychobiologic;psychologic;Psychology;Psychopathology;psychosocial;psychosocial outcome;Quality of life;recruit;Relapse;Research;resilience;resilience factor;Resources;response;Risk;Risk Factors;Science;screening;Short-Term Memory;skills;Social support;Stress;stressor;Symptoms;Training;Treatment Protocols;Up-Regulation;Vulnerable Populations;Work;Writing;young adult;Youth

PROJECT_TITLE: Psychobiological stress vulnerability, executive control, and emotion regulation in children and adolescents with cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Digestive Diseases;Inflammatory Bowel Disease;Neurosciences

ORG_CITY: COLUMBIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative Inflammatory Bowel Disease (IBD) is a chronic condition involving aberrant immune responses and recurring inflammation in the intestine and throughout the body. Patients with IBD are at risk for cardiovascular diseases, and, for unknown reasons, their mesenteric arteries do not properly regulate blood flow to the gut. The purpose of our project is to study how the perivascular nerves, immune cells, and adipose tissue around these arteries interact to regulate blood vessel function in health vs. IBD to identify new targets for the treatment of this debilitating disease.

PI_NAMEs: BOERMAN, ERIKA MARY (contact)

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: Address;adipokines;Adipose tissue;Affect;afferent nerve;Arteries;Atrophic;Binding;Biochemical;Biological Assay;Blood flow;blood flow measurement;Blood Vessels;Calcitonin Gene-Related Peptide;Calcitonin-Gene Related Peptide Receptor;Cannulations;Capsaicin;Cardiovascular Diseases;cardiovascular disorder risk;Cells;chemokine;Chronic;Chronic Disease;Colitis;Colonic inflammation;comorbidity;confocal imaging;constriction;cytokine;Defect;Denervation;Development;Disease;electric field;Endothelial Cells;Endothelium;Excision;Flow Cytometry;Follow-Up Studies;Functional disorder;gut inflammation;Health;Helicobacter;Helicobacter hepaticus;Histologic;Image;Image Cytometry;Immune;Immune response;Impairment;improved;in vivo;Incidence;Infiltration;Inflammation;Inflammation Mediators;Inflammatory Bowel Diseases;insight;Interleukin-10;Intestines;Lasers;Link;LoxP-flanked allele;Macrophage;Macrophage Activation;Measures;Mediating;Mesenteric Arteries;Mesentery;mouse model;Mus;Nerve;Neuroimmune;Neuropeptides;neurotransmitter release;Neurotransmitters;Pathogenesis;Pathway interactions;Patients;peptide P;Peptide Receptor;Perfusion;Population;Preparation;prevent;Quality of life;receptor;Recurrence;Research;Role;Sensory;Severities;Severity of illness;Signal Pathway;Signal Transduction;Smooth Muscle;Substance P;TACR1 gene;Testing;Therapeutic;transcriptome sequencing;Transgenic Mice;Tunica Adventitia;Vascular Diseases;vascular inflammation;vasoconstriction;Vasodilation;Vasomotor;Visualization;Work

PROJECT_TITLE: Role of sensory nerves in perivascular inflammation and vasomotor dysfunction with inflammatory bowel disease

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anorexia;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Mental Illness;Microbiome;Nutrition;Serious Mental Illness;Women's Health Research

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Anorexia nervosa is a deadly psychiatric illness defined by low body weight and associated with changes to many physiological systems in the body. This project will compare immune function and gut microbiome composition in a sample of female outpatients with anorexia nervosa and healthy comparison participants, and establish whether any differences are related to eating disorder symptoms. This basic knowledge will provide the required foundation to evaluate and interpret immune and gastrointestinal physiology in this clinical cohort, a required first step towards development of innovative, personalized treatments targeting these systems in anorexia nervosa.

PI_NAMEs: BRODRICK, BROOKS BARRETT (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Adult;Adult women;Ambulatory Care;Animal Model;Anorexia Nervosa;Award;Behavior;Behavior Disorders;Behavioral Symptoms;Binge Eating;Biological Markers;Biometry;Board Certification;Body Weight;Brain;career development;Clinical;cohort;Complex;cytokine;Data;design;Development;Disease;dysbiosis;Eating Behavior;Eating Disorders;Energy Intake;Exercise;Experimental Designs;Female;Foundations;Functional disorder;Future;gastrointestinal function;Gastrointestinal Physiology;Genomic DNA;Goals;gut microbes;gut microbiome;gut microbiota;Human;Immune;immune function;Immune response;Immune system;Immunological Models;immunological status;Immunology;improved;indexing;Individual;Inflammation;Inflammatory;inflammatory marker;innovation;Inpatients;Interleukin-1 beta;Interleukin-6;Internist;intestinal epithelium;K-Series Research Career Programs;Knowledge;Link;Lipopolysaccharides;Literature;Measures;Mediating;medical complication;Mental Depression;Mental disorders;Mentors;Mentorship;Meta-Analysis;Metagenomics;microbiome composition;microbiota composition;Molecular;Neurobehavioral Manifestations;neuroimmunology;novel strategies;Occupations;Outpatients;Participant;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;personalized medicine;Persons;Phenotype;Physiological;Physiological Processes;Physiology;Post-Traumatic Stress Disorders;Production;Psychopathology;purge;Recovery;Reporting;Research;Research Methodology;Research Project Grants;responsible research conduct;rRNA Genes;Sampling;Science;Science Enrichment;Scientist;Secure;Self Perception;Shapes;Shotgun Sequencing;Site;Specimen;Stratification;Symptoms;System;systems research;Taxonomy;TNF gene;Training;translational physician;Translational Research;Weight;Woman;Women's cohort

PROJECT_TITLE: Immune Dysregulation in Eating Disorders (ID-ED)

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Estrogen;Genetics;Neurosciences;Nutrition;Obesity;Physical Activity;Prevention;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE – RELEVANCE TO PUBLIC HEALTH Poor metabolic health and reduced activity is prevalent in older humans, especially with expanded longevity. Using mouse models, we discovered a small cluster of neurons in the brain that control a sex- dependent ancillary activity circuit in females. We aim to leverage our findings to understand age-related metabolic decline commonly experienced by postmenopausal women.

PI_NAMEs: INGRAHAM, HOLLY A. (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Affect;Age;age related;aged;anatomical tracing;Behavior;Behavior Control;Behavioral;Body Weight;Body Weight decreased;Brain;brain control;Cell Physiology;CRISPR-mediated transcriptional activation;Cues;Data;Dependence;designer receptors exclusively activated by designer drugs;dosage;Drops;Electrophysiology (science);Environment;ESR1 gene;Estrogens;Estrus;experience;falls;Female;Gene Dosage;Genetic;Genetic Recombination;Goals;Health;Hormonal;Hormone Responsive;Hormones;Human;Hypothalamic structure;improved;inhibitory neuron;innovation;insight;Investments;Knockout Mice;Life;Longevity;male;Maps;Medial;Mediating;Melanocortin 4 Receptor;melanocortin receptor;Metabolic;Metabolic Control;metabolic fitness;Methods;Molecular;Molecular Profiling;mouse model;Mus;neural circuit;Neurons;neurophysiology;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Outcome;Output;Pathway interactions;Physical activity;Physiological;Population;Postmenopause;Process;Proestrus;Property;Public Health;repetitive behavior;Reproduction;response;Role;sex;Signal Transduction;Slice;transcriptome sequencing;Travel;Viral;Woman;Work;α-Melanocyte stimulating hormone

PROJECT_TITLE: Dissecting a hormone-responsive processor for female activity and repetitive behavior

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Disability Research;Hearing Loss;Pediatric

ORG_CITY: WASHINGTON

ORG_NAME: AG BELL ASSN FOR DEAF & HARD OF HEARING

ORG_STATE: DC

PHR: The effects of hearing loss and deafness is a global health issue that knows no borders – over 466 million people are affected by hearing loss and 34 million of them are children. Lack of information and resources prove to be the main obstacles toward their success in developing language, and among those who most need the information on advances in hearing health research and therapy are professionals in Listening and Spoken Language. The AG Bell Global Symposium ensures that these professionals have the latest information on research that is changing deafness across the globe.

PI_NAMEs: GUIGNARD, GAYLA  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TITLE: AG Bell Global Listening & Spoken Language Symposia

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Heart Disease - Coronary Heart Disease;Physical Activity;Prevention

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Despite improvements in early diagnosis and treatment, ST-segment elevation myocardial infarction (STEMI) remains a leading cause of morbidity and mortality in the US, and patients with STEMI are at significantly increased risk for developing heart failure. Numerous studies have identified inflammation as a risk factor for heart failure, and in phase II clinical trials, Interleukin-1 (IL-1) blockade has shown to blunt the acute inflammatory response and prevent heart failure in patients with STEMI. This application will evaluate the mechanism by which targeted IL-1 blockade may preserve cardiorespiratory fitness and cardiac reserve, and prevent the incidence of new-onset heart failure in patients with STEMI.

PI_NAMEs: ABBATE, ANTONIO ;VAN TASSELL, BENJAMIN W (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acute;Acute myocardial infarction;adjudication;Affect;anakinra;Anti-Inflammatory Agents;Biological Markers;Boston;C-reactive protein;Cardiac;cardiac depression;Cardiac Output;Cardiopulmonary;cardiorespiratory fitness;Cessation of life;Clinical;Clinical Data;Clinical Research;Clinical Trials;Coupled;cytokine;Doctor of Pharmacy;Doctor of Philosophy;Doppler Echocardiography;Double-Blind Method;Early Diagnosis;Early treatment;Echocardiography;Event;Exercise;Exercise Test;Fever;Functional disorder;healing;Heart failure;heart function;heart imaging;heart preservation;Hospitalization;Hospitals;Image;Impairment;improved;Incidence;Infarction;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;insight;Interleukin-1;Intervention;Ischemia;Left;Left Ventricular Ejection Fraction;Link;Magnetic Resonance;Measures;Mediator;Morbidity - disease rate;mortality;multidisciplinary;Muscle;myocardial damage;Myocardial dysfunction;Myocardial Infarction;Myocardium;novel;novel strategies;Outcome;Oxygen Consumption;Patients;phase 2 study;Phase II Clinical Trials;Placebo Control;Placebos;preservation;prevent;Prevention;Prevention approach;primary endpoint;Process;Quality of life;Quality of Life Assessment;Randomized;Recombinant Interleukin-1;Reperfusion Therapy;response to injury;Risk;Risk Factors;ROC Curve;Role;Sensitivity and Specificity;systemic inflammatory response;Testing;Time;Tissues;Translating;Ventricular;Woman

PROJECT_TITLE: Prevention of heart failure with IL-1 blockade: a mechanistic study

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Regenerative Medicine;Wound Healing and Care

ORG_CITY: GREENVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: EAST CAROLINA UNIVERSITY

PHR: Project Narrative – Public Health Relevance Peripheral arterial disease (PAD) is caused by atherosclerosis in the legs where blood flow is restricted. The central focus of PAD research for decades has been to understand and alter endothelial cell biology, yet no progress has been made towards effective therapeutic design. We will combine our use of innovative mouse genetic models, established PAD relevant laboratory models, innovative tools (gene therapy designed expression viruses), and a heterogeneous PAD patient population to fully interrogate the role of BAG3 as both a potential cause of pathology (in the case of the variants pre-disposing African Americans to severe disease outcomes) and as a potential target for therapeutic development.

PI_NAMEs: MCCLUNG, JOSEPH MATTHEW (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Adenoviruses;Affect;African American;African American population;African ancestry;Amino Acids;Amputation;angiogenesis;Apoptosis;Arteries;Atherosclerosis;Automobile Driving;BCL2 gene;biobank;Bioenergetics;Biological;Blood flow;Blood Vessels;Cardiac;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;Cell Separation;cell type;Cells;Cellular biology;Cessation of life;Clinical;Code;cohort;Communication;complex IV;critical limb Ischemia;cytochrome c oxidase;Data;demographics;density;design;Dilated Cardiomyopathy;Disease;Disease Outcome;Disparity;Endothelial Cells;Environment;Exertion;Gangrene;gene therapy;Genes;Genetic;Genetic Models;genetic variant;Glycolysis;Hindlimb;Histologic;Human;improved;In Vitro;in vivo;Inbred BALB C Mice;Incidence;Individual;Injury;innovation;Intermittent Claudication;Ischemia;Laboratories;Leg;limb ischemia;Limb structure;Link;Lower Extremity;Mediating;Medical;Metabolic;Mitochondria;mitochondrial dysfunction;Modeling;Molecular Chaperones;Morbidity - disease rate;mortality;mouse genetics;Mus;Muscle;Muscle Cells;Muscle Fibers;Muscle Mitochondria;muscle regeneration;Mutation;Myocardium;myogenesis;Myopathy;Natural regeneration;necrotic tissue;neovascularization;novel;Outcome;Outcome Measure;overexpression;Pain;paracrine;Pathology;patient population;Patient-Focused Outcomes;Patients;Perfusion;Peripheral;Peripheral arterial disease;Pharmaceutical Preparations;Phenotype;Physiological;pleiotropism;Pre-Clinical Model;preclinical study;Preclinical Testing;Prevention;Procedures;Process;Proliferating;Proteins;public health relevance;Quantitative Trait Loci;Race;racial disparity;Recovery;Research;Research Personnel;Rest;restoration;revascularization;Risk;Role;Scaffolding Protein;screening;skeletal;Skeletal Muscle;Striated Muscles;Surgeon;targeted treatment;Testing;Therapeutic;therapeutic candidate;therapeutic development;Therapeutic Effect;therapeutically effective;therapy design;Tissues;tool;Transgenic Organisms;translational scientist;Variant;Virus;Work

PROJECT_TITLE: Variant Determinants of African American Limb Pathology in Peripheral Arterial Disease

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Substance Misuse

ORG_CITY: SYRACUSE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SYRACUSE UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative The Syracuse University-Summer Training in Alcohol Research (SU-STAR) program aims to address the persistent imbalanced engagement of racial/ethnic minorities and individuals with socioeconomic disadvantages and disabilities in science, especially in health-related sciences. The proposed program will help meet the nation's need for a diverse pool of talented scientists by enhancing underrepresented undergraduate students' participation in alcohol and health research and facilitating their admission into graduate school. Ultimately, the SU-STAR program will expand a pipeline of diverse graduate students in health research, strengthening alcohol science incorporating diverse perspectives and life experiences.

PI_NAMEs: PARK, AESOON  (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: Address;Admission activity;alcohol research;Alcohols;Award;Bachelor's Degree;career;career development;Characteristics;cohort;Communities;coping;Degree program;design;Development;disability;Discipline;Education;education research;educational atmosphere;Educational workshop;Enrollment;ethnic minority;Evaluation;Event;experience;Faculty;Fostering;Graduate Education;graduate school;graduate student;Health;Health Sciences;Individual;innovation;interest;Internships;journal article;Learning Skill;Life Experience;Medical center;member;Mentors;Methods;Newsletter;Outcome;Participant;Patient Recruitments;people of color;Postdoctoral Fellow;Process;professional atmosphere;Program Effectiveness;Program Evaluation;programs;Psychology;Publications;Race;racial minority;Records;recruit;Research;research and development;Research Personnel;Research Project Grants;Research Training;response;satisfaction;Science;Scientist;skills;social;Socialization;socioeconomic disadvantage;Structure;student participation;Students;success;summer program;summer research;support network;symposium;Talents;Training;Training Activity;training opportunity;Training Programs;undergraduate research experience;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities

PROJECT_TITLE: The Syracuse University-Summer Training in Alcohol Research (SU-STAR) Program

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: FAIRFAX

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGE MASON UNIVERSITY

PHR: PROJECT NARRATIVE The U.S. is one of just three industrialized countries that does not have a federal paid sick leave (PSL) mandate and many employees do not have access to PSL, states and localities have adopted PSL mandates given the federal void. Work commitments and the prospect of lost wages are factors contributing to delays in seeking medical care, including mental healthcare treatment, both for employees and for their dependents (e.g., children and partners). This project will provide the first causal estimates of the effect of state and local PSL mandates on access to PSL among those with mental health disorder, use of mental healthcare, and indicators of potential quality of mental healthcare received, and will examine how community-level factors (e.g., mental healthcare workforce and socioeconomic status) mediate PSL mandate impacts.

PI_NAMEs: MACLEAN, JOHANNA CATHERINE (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: Address;Adopted;Adult;Affect;American;Appointment;Appointments and Schedules;Attention;barrier to care;Caring;Child;Chronic;Cities;clinical care;Communities;community-level factor;Consumption;cost;Country;County;Data;Data Sources;design;Developed Countries;Educational Status;effective therapy;Employee;Ethnic Origin;experience;Family;federal policy;flexibility;Gender;Government;health care consultation;Health Care Costs;health care service utilization;Health Personnel;Health Policy;health service use;Healthcare;Hour;Immune;improved;Income;Individual;Infrastructure;insurance claims;Insurance Coverage;Laws;Literature;Major Depressive Disorder;Mediating;Medicaid;Medical;Mental disorders;Mental Health;Mental Health Services;Methods;Morbidity - disease rate;mortality;Motion;National Health Interview Survey;National Institute of Mental Health;Outcome;Patients;Pattern;Persons;Pharmaceutical Preparations;physical health service;Policies;Population;Prevalence;prevent;Primary Care Physician;Privatization;Probability;Process;Provider;Psychiatrist;Public Health;Public Policy;Quality Indicator;Quasi-experiment;Race;Recommendation;Reporting;Reproducibility;Research;Residential Treatment;Schedule;service utilization;sex;Sick Leave;Societies;Socioeconomic Status;Suicide;Surveys;Time;Travel;Uninsured;United States;Variant;Visit;Wages;Wait Time;Work

PROJECT_TITLE: Paid Sick Leave Mandates and Mental Healthcare Service Use

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Rehabilitation;Stroke

ORG_CITY: CHARLESTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Approximately 800,000 Americans experience a stroke each year, with a resultant cost of care estimated in the hundreds of millions of dollars. Restoring fully independent gait function is a common goal following a stroke, but gait instability and a high risk of falls often limit functional mobility, causing a decrease in quality of life. This project will investigate the use of novel methods of perturbation training to improve post-stroke gait instability, with the potential to serve as the basis for the development of novel gait rehabilitation techniques able to increase the quality of life for thousands of stroke survivors.

PI_NAMEs: DEAN, JESSE C. (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Address;American;balance testing;Balance training;Behavior;care costs;chronic stroke;Clinical;Clinical Trials;clinically relevant;Communities;Control Groups;design;Development;Effectiveness;Ensure;Environment;Equilibrium;experience;Fall prevention;fall risk;falls;fear of falling;foot;Gait;gait rehabilitation;Goals;high risk;improved;Incidence;innovation;insight;Intervention;Intervention Studies;Investigation;knowledge of results;Laboratories;Leg;Link;Location;Locomotor training;Measures;Mechanics;Methods;Motion;Movement;Nature;Neuromechanics;novel;Outcome;Patients;Pelvis;Persons;Play;Population;post stroke;Posture;pressure;prevent;promote resilience;Quality of life;Randomized;rehabilitation paradigm;Rehabilitation therapy;Research;Resources;response;Risk Reduction;Role;Specificity;Stroke;Stroke prevention;stroke rehabilitation;stroke survivor;success;Techniques;therapy development;Training;Walking;walking stability;Width;Work

PROJECT_TITLE: Proactive and reactive perturbation training to reduce falls and improve gait stability in people with chronic stroke

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Nutrition;Physical Activity;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This integrated training and research proposal focuses on the longitudinal associations of two physical activity- related measures of energy expenditure with cognition and Alzheimer’s disease (AD) biomarkers among older adults who are cognitively normal, as well as those with mild cognitive impairment and mild AD dementia. Potential biological and genetic factors that may modify and/or mediate these associations will also be examined.

PI_NAMEs: DOUGHERTY, RYAN JAMES (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Acceleration;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;apolipoprotein E-4;Baltimore;Biological;Biological Markers;Brain;brain volume;cardiorespiratory fitness;career;career development;cerebral atrophy;Cerebrovascular Circulation;Clinical Research;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive function;cognitive performance;cohort;cost;Data;Dementia;Development;Development Plans;Diagnostic;Dimensions;Disease;Disease Progression;educational atmosphere;Energy Metabolism;Exercise;Genetic;Genotype;Goals;hippocampal atrophy;Impaired cognition;Individual;insight;Intervention;Knowledge;Life Style;lifestyle factors;Link;Literature;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;Mentored Patient-Oriented Research Career Development Award;Mentored Research Scientist Development Award;Mentorship;mild cognitive impairment;Mitochondria;Muscle Mitochondria;Musculoskeletal System;neuroimaging;novel;older adult;Older Population;Outcome;Oxygen;Pharmaceutical Preparations;Physical activity;Physiological;Positron-Emission Tomography;Predictive Value;programs;prospective;Publishing;Research;Research Personnel;Research Proposals;research study;Research Training;responsible research conduct;Rest;Risk;Risk Assessment;Risk Reduction;Role;sex;Skeletal Muscle;skills;specific biomarkers;Specificity;Statistical Data Interpretation;tau aggregation;tau Proteins;Techniques;Therapeutic;Time;Training;Translational Research;Walking;walking speed;Work

PROJECT_TITLE: Energy expenditure, cognitive function, and biomarker features of Alzheimer's disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Estrogen;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: TUCSON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE This study is focused on the topic of postmenopausal shifts in follicle stimulating hormone (FSH) and how FSH relates to obesity development and breast cancer risk. The results will provide insight into obesity-breast cancer mechanisms and will enhance our ability to target preventive therapies. Based on study results, hormone-related medications on the market or in development can be tested specifically for breast cancer prevention.

PI_NAMEs: BEA, JENNIFER WRIGHT (contact);OCHS-BALCOM, HEATHER M

PROGRAM_OFFICER_NAME: SIMONDS, NAOKO ISHIBE

PROJECT_TERMS: Accounting;Adipose tissue;adjudication;Age;Ancillary Study;arm;Attention;Automobile Driving;Bilateral oophorectomy;Binding;Biological Markers;Body Composition;Body fat;Body mass index;Body Weight;bone;Breast;breast cancer diagnosis;Breast Cancer Prevention;Breast Cancer Risk Factor;breast tumorigenesis;Cancer Prevention Intervention;cancer subtypes;case control;Case/Control Studies;Clinical;Clinical Trials;cohort;Computer software;Conjugated Equine Estrogens;Data;design;Development;druggable target;Dual-Energy X-Ray Absorptiometry;Endocrinology;epidemiology study;Estradiol;Estrogen receptor positive;Estrogens;Ethnic Origin;experience;Feedback;Follicle Stimulating Hormone;Follicle Stimulating Hormone Receptor;follow-up;Future;Goals;Gonadotropin Releasing Hormone Inhibitor;Goserelin;Growth Factor;Hormonal;hormone therapy;Hormones;Human;Hysterectomy;Image;improved;Incidence;Inflammatory;innovation;insight;interest;Investigation;Joints;large datasets;Leptin;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Mammary Neoplasms;Marketing;Measures;Mediating;Mediator;Medroxyprogesterone 17-Acetate;Menopause;Modeling;novel;Obesity;obesity development;Observational Study;Osteoporosis;Ovarian;Participant;Pharmaceutical Preparations;phase 3 testing;Pilot Projects;Postmenopause;pre-clinical;Pre-Clinical Model;Premenopause;Prevention;Preventive therapy;Process;Production;Race;Randomized;receptor;Reporting;research clinical testing;Resources;Risk Factors;Role;Safety;Sampling;Scanning;Serum;Source;subcutaneous;Testing;Therapeutic;Therapy trial;Time;Translations;Visceral;waist circumference;Woman;Women's Health

PROJECT_TITLE: Role of FSH in postmenopausal obesity and breast cancer

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: DE

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Rare Diseases;Telehealth

ORG_CITY: Rockville

ORG_NAME: PEDIAMETRIX INC.

PHR: NARRATIVE  Delayed identification of infant head malformation is causing unnecessary medical complications and societal costs, partly because of the absence of tools available to pediatric offices. For this Fast-track SBIR proposal, PediaMetrix Inc. has joined forces with clinical institutions to develop and evaluate a 3D mobile scanning tool that provides cranial volume and malformation measurements. Our tool, called SoftSpotTM, will improve the early detection and management of infant cranial malformations at the point-of-care and avoid delayed, costly and intensive treatments.

PI_NAMEs: AALAMIFAR, FERESHTEH  (contact);SEIFABADI, REZA

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: 3-Dimensional;Address;Affect;Algorithms;Attention;Auditory Perceptual Disorders;Brain;Cellular Phone;Cephalic;Cephalometry;Child;Childhood;Classification;Clinical;commercialization;Complex;cost;Craniosynostosis;cranium;Data;Data Analyses;Data Collection;deep learning model;Deformity;design;Detection;Development;Diagnosis;digital health;digital tool;Early Diagnosis;Early treatment;effective therapy;Epidemic;Evaluation;experience;Feasibility Studies;Growth;Head;Head circumference;Health;Health Care Costs;Health Personnel;Health Professional;Helmet;Home;Image;Impairment;improved;indexing;infancy;Infant;infant monitoring;Institution;Intracranial Hypertension;Investigation;Left;Location;Machine Learning;machine learning method;malformation;Mandible;Measurement;Measures;medical complication;Methods;mHealth;millimeter;Mission;mobile application;mobile computing;Mobile Health Application;Monitor;Morbidity - disease rate;Motion;new technology;Operative Surgical Procedures;Patients;Pediatric Hospitals;pediatrician;Pediatrics;Penetration;Phase;Physical therapy;plagiocephaly;point of care;Positioning Attribute;Prevalence;prevent;prototype;quantitative imaging;reconstruction;Reporting;research clinical testing;Scanning;screening;sensor;shape analysis;Shapes;Site;Small Business Innovation Research Grant;smartphone application;social anxiety;societal costs;Standardization;Structure;support tools;Technology;Time;tool;Torticollis;Training;usability;user-friendly;Visit;Well Child Visits;Work

PROJECT_TITLE: Mobile Three-Dimensional Screening for Cranial Malformations


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative: We will study the role of glycinergic inhibition from the medial nucleus of the trapezoid body in sound localization processing performed by the medial and lateral superior olive. The proposed aims will optogenetically manipulate this inhibitory projection while assessing the effects on sound localization, allowing us to discriminate between several models that have been proposed. A better understanding of these mechanisms in normal hearing may lead to a better understanding of common hearing disorders that affect spatial hearing.

PI_NAMEs: KLUG, ACHIM  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Address;Affect;age related;Area;Auditory;Auditory Brainstem Responses;Auditory system;autism spectrum disorder;binaural hearing;Brain;Brain Stem;Cell Nucleus;Central Hearing Loss;Chlorides;design;Ear;Electrodes;Environment;experimental study;Frequencies;Future;Generations;Gerbils;Halorhodopsins;Hearing;Hearing problem;Implant;in vivo;Knock-out;lateral superior olive;Lead;Light;Location;Measures;Medial;medial superior olive;Mediating;Medical;Methods;Modeling;Monitor;neural;neural circuit;neuromechanism;Neurons;normal hearing;optical fiber;optogenetics;Output;Pathway interactions;Patients;Play;Population;Process;Pump;response;Rodent;Role;Shapes;sound;sound frequency;Sound Localization;Source;Testing;therapy design;Time;trapezoid body

PROJECT_TITLE: Fast Inhibition in the Sound Localization Pathway


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: BRONX

ORG_NAME: FORDHAM UNIVERSITY

PHR: Project Narrative The burden of HIV/AIDS falls hardest on people who inject or use drugs, who are often among a nation’s poorest, most disempowered and stigmatized populations. To date, there is a paucity of well-qualified scientists with the unique investigative skills required to inform research ethics decision-making to adequately protect the rights and welfare of these vulnerable populations. Through its intensive summer training program, funded mentored research experience, and public online resources, the Fordham University HIV and Drug Abuse Prevention Research Ethics Training Institute will provide early-stage clinical scientists with the competencies to address the global need for empirical and educational resources to inform research ethics practices and policies involving persons with or at-risk for HIV and drug addiction.

PI_NAMEs: FISHER, CELIA B (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: addiction;Address;career;career development;Clinical;Collaborations;Communities;community advisory board;community engagement;community involvement;Community Participation;Competence;Data;Decision Making;design;Development;Discrimination;Drug abuse;drug abuse prevention;Drug Addiction;Drug usage;Education;education resources;Educational Curriculum;Educational process of instructing;Empirical Research;empowerment;Ensure;Ethics;evidence base;experience;falls;Funding;Generations;Goals;Grant;Guidelines;HIV;HIV/AIDS;Individual;Information Dissemination;Information Networks;innovation;Institutional Review Boards;International;Intervention Studies;Investigation;investigator training;Knowledge;Language;Manuscripts;marginalization;Measures;meetings;Mentors;Methods;National Institute of Drug Abuse;new technology;online resource;Online Systems;pandemic disease;Participant;patient engagement;Pattern;pedagogy;peer;Persons;Phase;Policies;Population;Prevention Research;Procedures;Process;Program Development;programs;prospective;Publications;Qualifying;recruit;Regulation;Reproducibility;Request for Applications;Research;Research Design;Research Ethics;Research Ethics Committees;Research Methodology;Research Personnel;Research Project Grants;Resistance;Resources;Rights;Risk;Science;Scientist;Series;skills;social media;social stigma;Stigmatization;Substance abuse problem;summer institute;Training;Training Programs;treatment research;Trust;United States National Institutes of Health;Universities;Update;vulnerable community;Vulnerable Populations;webinar;welfare;Work;Writing


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This proposal is to continue the ongoing Monitoring the Future (MTF) Panel study, which has surveyed new nationally representative samples of high school seniors every year since 1976 to track patterns and consequences of substance use and HIV/AIDS risk and protective behaviors. This application covers five new longitudinal data collections in 2023 through 2027 from national samples of adults ages 19 through 65 (approximately 120,000 people total). This application – the MTF Panel – is part of the integrated MTF study; a companion R01 application (the MTF Main) requests funding to continue (a) to collect annual nationally representative cross-sectional data from secondary school students, and (b) to analyze all cross-sectional and longitudinal data.

PI_NAMEs: PATRICK, MEGAN E. (contact)

PROGRAM_OFFICER_NAME: LOPEZ, MARSHA

PROJECT_TERMS: Achievement;addiction;Address;Adolescence;Adolescent;Adult;Affect;Age;age related changes;aged;Alcohol consumption;Alcohols;Annual Reports;Attitude;Basic Science;Behavior;Belief;Cannabis policy;Categories;Cessation of life;cohort;Cohort Effect;college;Communities;Companions;COVID-19;Data;Data Analyses;data archive;Data Collection;Deposition;depressive symptoms;design;Development;Developmental Course;Drug Prescriptions;Drug usage;Drunk driving;Education;Educational workshop;eighth grade;Epidemiology;Ethnic Origin;Etiology;Event;experience;Family;Family member;follow-up;Funding;Future;Gender;Goals;Grant;Health;Heterogeneity;high school;High School Student;HIV;HIV/AIDS;Home;Illicit Drugs;improved;indexing;Individual;Injections;Knowledge;Legal;Life;Life Cycle Stages;Literature;longitudinal dataset;longitudinal design;Longitudinal trends;Longterm Follow-up;marijuana use;Measurement;Medical;Modality;Monitor;Morbidity - disease rate;mortality;National Institute of Drug Abuse;Needle Sharing;Nicotine;novel therapeutics;Occupational;older adult;Online Systems;Pattern;peer;Personal Satisfaction;Persons;Pharmaceutical Preparations;Policies;Population;Prevalence;Prevention;programs;protective behavior;protective factors;Race;Random Allocation;recruit;Reporting;Request for Applications;Research;Research Personnel;research study;Risk;Risk Behaviors;Risk Factors;Role;Sampling;Schools;Sex Behavior;social;Social Environment;socioeconomics;Source;Students;Subcategory;Subgroup;substance misuse;substance use;Substance Use Disorder;Surveys;Symptoms;Teenagers;tenth grade;tobacco products;Tobacco use;Training;transmission process;trend;twelfth grade;United States;United States National Institutes of Health;university student;vaping;Work;young adult

PROJECT_TITLE: Monitoring the Future: A Cohort-Sequential Panel Study of Drug Use, Ages 19-65

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Epilepsy;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Glioblastoma and tumor-related epilepsy are a pair of intimately connected neurological diseases with no curative or effective treatments available despite decades worth of preclinical and clinical research. Unlike previous studies that relied on tumor xenografts, we use a novel genetically induced, native mouse tumor model that recapitulates many hallmarks of the human disease progression, and that allows us to study the disease in vivo in an immunocompetent model organism. Here we propose to study the feedback loop of tumor invasion and neural hyperexcitability and explore potential interventions by mitigating the effects of excess glutamate or silencing focal groups of neurons to slow down tumor growth and reduce risk of epilepsy and other neurological comorbidities.

PI_NAMEs: MEYER, JOCHEN  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Acceleration;Acute;Address;Affect;AMPA Receptors;antiporter;Area;Astrocytes;awake;Behavior monitoring;Behavioral;Brain;Calcium;Cell Death;cell motility;Cell Proliferation;Cells;Chronic;Clinical Research;Communication;comorbidity;Coupled;Coupling;CRISPR/Cas technology;curative treatments;Cystine;Death Rate;Deceleration;density;designer receptors exclusively activated by designer drugs;Disease;Disease Progression;Distant;effective intervention;effective therapy;Electroencephalography;Epilepsy;Epileptogenesis;Evolution;experience;experimental study;Feedback;Floods;gain of function;Genes;Genetic;Genetic Models;Genetic study;genetic variant;Glioblastoma;Glutamate Receptor;glutamatergic signaling;Glutamates;Glypican;Goals;GPC3 gene;Growth;Homeostasis;human disease;Hyperactivity;Image;imaging study;Immunocompetent;Impairment;improved;in vivo;in vivo imaging;indexing;Inflammation;insight;Interneurons;Intervention;Invaded;islet;Link;Malignant - descriptor;Measures;Mediating;Methods;model organism;Modeling;Monitor;mortality;Motility;Motion;mRNA Expression;Mus;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Nature;neoplastic cell;Nervous System Disorder;neural;neural network;Neuroepithelial, Perineurial, and Schwann Cell Neoplasm;Neuroglia;Neurologic;neuronal tumor;Neurons;neuroregulation;NF1 gene;novel;Pathway interactions;Patients;Pattern;Phase;Photons;Population;pre-clinical research;Process;Proliferating;Protein Secretion;Publishing;Quality of life;Reporting;Resolution;Risk Reduction;Runaway;Seizures;Signal Pathway;Source;Symptoms;Synapses;synaptic inhibition;synaptogenesis;Techniques;Testing;Therapeutic;Time;Tissues;TP53 gene;tumor;Tumor Cell Invasion;tumor growth;tumor progression;Tumor Tissue;tumor xenograft;two-photon;Variant

PROJECT_TITLE: RECIPROCAL FEEDBACK MECHANISMS OF GLIOBLASTOMA AND NEURONAL NETWORK HYPEREXCITABILITY

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE  This project will contribute to knowledge about the relationships between staffing levels of registered nurses (RNs), licensed practical nurses (LPNs), certified nurse assistants (CNAs), physical therapists, occupational therapists, speech-language pathologists (i.e. speech therapists), and social workers, and several outcomes for residents in nursing homes, including deficiencies. It will provide information for both nursing homes that treat large populations of residents with Alzheimer’s disease and related dementias (ADRD) and nursing homes with few residents with ADRD. This information will enhance the ability of policy makers at all levels to plan and develop policies that will improve workforce planning and allocation and ultimately will improve outcomes for residents with ADRD.

PI_NAMEs: MUKAMEL, DANA B (contact)

PROGRAM_OFFICER_NAME: KELLER, CHANDRA

PROJECT_TERMS: Accounting;Address;Administrator;Advocate;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Caring;Case Mixes;Certification;cost;Data;Dementia;Development;Discipline of Nursing;econometrics;Federal Government;Growth;Guidelines;Health;Home;Home Nursing Care;improved;improved outcome;Industry;insight;Knowledge;Language;Licensed Practical Nurse;Link;Marketing;Measures;Minority;National Institute on Aging;Nurses;nursing care quality;Nursing Homes;Nursing Staff;nursing standards;Occupational;Occupational Therapist;Outcome;Outcome Measure;Pathologist;Patients;physical therapist;Policies;Policy Maker;Population;Prevalence;Publishing;Quality Indicator;Quality of Care;Registered nurse;Regulation;Reporting;Research;Social Work;Social Workers;Speech;Speech Therapist;Structure;Techniques;Testing;Translating;United States Centers for Medicare and Medicaid Services;Variant;Visit;web app

PROJECT_TITLE: Staffing and Health Outcomes in Nursing Homes for Residents with and without Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-A(02)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Bioengineering;Biomedical Imaging;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: NARRATIVE This study aims to use Deep Learning to simultaneously accelerate knee MRI acquisition and automate post processing pipelines including multi tissue segmentation, detection and severity staging of osteoarthritis degenerative changes. The proposed study builds a novel translational platform to revolutionize knee MR images in research studies, but also is paradigm-shifting in that it may provide a first step towards on real time automatic image inspection and personalized imaging protocolling.

PI_NAMEs: MAJUMDAR, SHARMILA  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: 3-Dimensional;Acceleration;adversarial learning;Area;Automation;Bayesian Modeling;Benchmarking;Cartilage;Characteristics;Clinical;clinical application;clinical practice;clinical translation;clinically relevant;cohort;Collection;Complement;convolutional neural network;Data;Data Set;data space;data to knowledge;deep learning;deep learning model;Degenerative polyarthritis;density;design;Detection;Development;domain mapping;Ensure;Evaluation;experimental study;feature extraction;heterogenous data;Human;Image;Image Analysis;image processing;image reconstruction;Injury;joint destruction;Knee;Knee joint;Label;Learning;learning ability;Licensing;Magnetic Resonance Imaging;Manuals;Maps;Measurement;Methodology;Methods;Modeling;Morphology;MRI Scans;musculoskeletal imaging;neural network;new technology;novel;open source;Patient Triage;Patients;Performance;preservation;Probability;Process;prospective;Protocols documentation;Protons;radiologist;Radiology Specialty;Reader;Reading;reconstruction;recruit;Reproducibility;Research;research study;Resolution;Resource Sharing;Sampling;Scanning;sensor;Severities;Signal Transduction;Staging;Standardization;Statistical Distributions;supervised learning;System;Techniques;Testing;Thick;Time;Tissues;tool;Training;Translating;Translations;Uncertainty;validation studies;Vendor

PROJECT_TITLE: Ultra-Fast Knee MRI with Deep Learning

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health;Substance Misuse

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Infants born to opioid-dependent mothers living in poverty are at risk for a host of developmental problems, but effects can be buffered if mothers interact with their children in sensitive ways. This project assesses the efficacy of an intervention that targets parental sensitivity and is tailored to the needs of opioid-dependent infants. Effects are expected to be seen on maternal sensitivity and neural activity and on infant behavioral and biological outcomes.

PI_NAMEs: DOZIER, MARY  (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Affect;Age;Age Months;Attention;Autonomic nervous system;Behavior;Behavioral;biobehavior;Biological;Biology;Birth;Buffers;Caring;Child;Child Rearing;chronic pain;Dependence;Development;Early Intervention;Education;efficacy evaluation;evidence base;Face;Family;Female of child bearing age;fetal;fetal opioid exposure;Fingers;Frequencies;high risk;Home visitation;Hydrocortisone;infancy;Infant;Infant Behavior;infant outcome;Informal Social Control;Intervention;intervention effect;maternal opioid use;Mediating;medication-assisted treatment;men;Mothers;Nature;Neonatal Abstinence Syndrome;neonate;neural;Opiate Addiction;Opioid;opioid exposure;opioid use;Outcome;Parents;Pattern;Pharmaceutical Preparations;postnatal;Poverty;Pregnancy;prenatal;prescription opioid;Procedures;Production;programs;Randomized;randomized, clinical trials;Regulation;Reporting;Rewards;Risk;sex;steroid hormone;Structure;substance use;Symptoms;Third Pregnancy Trimester;Treatment Efficacy;Withdrawal Symptom;Woman

PROJECT_TITLE: Intervening with Opioid-Dependent Mothers Living in Poverty: Effects on Mothers' and Infants' Behavioral and Biological Regulation


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

PHR: Project Narrative Cell surface proteolysis is a key marker and modulator of cancer. We propose to develop transformative technologies and tools to determine how cancer cell surface proteomes are remodeled by KRAS induced proteolysis, and to develop antibodies to these key neo-epitopes as potential biomarkers and therapeutics.

PI_NAMEs: WELLS, JAMES A (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: 3-Dimensional;Antibodies;Antibody Affinity;Bacteriophages;Binding;Biological Markers;cancer biomarkers;cancer cell;Cancer cell line;Cell Line;Cell model;Cell secretion;Cell surface;Cell Surface Proteins;Cells;Coupled;CRISPR interference;Data;design;Disease;Drug Targeting;Engineering;Environmental Risk Factor;Event;experimental study;extracellular;Extracellular Domain;Extracellular Space;Generations;Human;Hypoxia;Immunooncology;inhibitor;insight;knock-down;KRAS2 gene;KRASG12D;Label;Libraries;Ligase;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;mutant;neoantigens;new technology;novel;Oncogenes;Oncogenic;pancreatic cancer model;pancreatic cell line;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;Peptide Hydrolases;Peptides;Phage Display;potential biomarker;Prostate-Specific Antigen;Protein Engineering;Proteins;Proteolysis;Proteome;Proteomics;Reagent;receptor;Receptor Activation;Site;small molecule inhibitor;Solid Neoplasm;Specificity;subtiligase;Surface;Technology;Therapeutic;Tissue Sample;tool;tumor;tumor microenvironment;two-dimensional;Urokinase

PROJECT_TITLE: New protein engineering-based tools and technologies for characterizing cell surface proteolysis in cancer cells for novel neo-epitope biomarkers and drug targets

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE This study will explore barriers and facilitators to participation in the Parent Infant Interac(X)tion Intervention (PIXI), a virtual parent-mediated intervention for caregivers of infants with neurogenetic conditions, among traditionally marginalized communities (e.g., Black/African American; Hispanic). Through frequent engagement with a targeted community advisory board and strategic interviewing strategies, this study will first gather formative, detailed information about challenges in virtual intervention implementation in these populations, leading to critical procedural changes to be implemented in a pilot of PIXI specifically with these groups. This work will gather important formative information to ensure that the PIXI protocol is developed in a way that maximizes access for diverse populations of individuals with infants identified to have rare neurogenetic conditions.

PI_NAMEs: BLANCHARD, SHERESA BOONE;WHEELER, ANNE CAROLINE (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: 22q;3 year old;acceptability and feasibility;accurate diagnosis;African American;American;Angelman Syndrome;bilingualism;Black race;caregiver interventions;Caregivers;Caring;Case Series;Caucasians;Child;Childhood;children of color;Clinical;Collaborations;Color;community advisory board;coping;cost;Data;design;Development;Developmental Delay Disorders;Diagnosis;Diagnostic;Disparity;early childhood;Early Diagnosis;Early Intervention;Educational Curriculum;efficacy evaluation;Enrollment;Equity;Ethnic Population;experience;Family;family support;Feasibility Studies;First Year Experience;Foundations;Fragile X Syndrome;Funding;Future;Genetic;Goals;health care availability;health equity;health inequalities;high risk;Hispanic;Home;implementation intervention;improved;Individual;Infant;insight;Intervention;intervention program;Interview;Latino;Life;Linguistics;low socioeconomic status;Manuals;marginalized community;Mediating;member;Modification;Neonatal Screening;neurogenetics;Newborn Infant;Outcome;Outcome Measure;Parents;participant interview;peer;Personal Satisfaction;Phase;pilot trial;Population;Population Heterogeneity;Prader-Willi Syndrome;preference;Program Accessibility;programs;prospective;Protocols documentation;provider intervention;Public Health;Publications;racial disparity;racial population;rare condition;Rare Diseases;recruit;remote delivery;Research;response;rural area;rural families;Sampling;screening panel;screening program;Series;service intervention;Spanish;Symptoms;Syndrome;telehealth;Therapeutic;Toddler;tool;Traction;Translating;Treatment Efficacy;virtual;virtual delivery;virtual intervention;Work

PROJECT_TITLE: Improving accessibility of virtual interventions for families of infants with neurogenetic conditions - Resubmission

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE Tobacco use is the leading cause of preventable and premature disease, disability, and death among Americans; its effects unequally burden the health of minoritized and marginalized groups who have more difficulty quitting. The STRONGER Scholar Program at MD Anderson will prepare the next generation of clinicians to understand, conduct, and evaluate innovative tobacco addictions research to meet the critical need for improved tobacco cessation care provision, particularly with groups adversely affected by tobacco disparities. The STRONGER Scholar Program will educate 16 doctoral students in clinically-focused training programs (psychology and social work) and 35 medical students to conduct tobacco addictions research and apply findings within clinical care provision; contributing to NIDA’s Racial Equity Initiative to increase racial/ethnic diversity in addictions research to better address associated health inequities, and aligning with its strategic plan and cross-cutting scientific priorities.

PI_NAMEs: REITZEL, LORRAINE R (contact)

PROGRAM_OFFICER_NAME: DUCHARME, LORI

PROJECT_TERMS: addiction;Address;Admission activity;Affect;American;Attention;Behavioral;behavioral and social science;behavioral health;Behavioral Sciences;Black race;Cancer Center;career;Career Choice;Caring;Cessation of life;Chronic Disease;Clinical;clinical care;clinical training;cohort;Collaborations;Communities;Competence;Coupled;Creativeness;Degree Completion;Degree program;Development;disability;Disease;Disparity;Diverse Workforce;doctoral student;Education;education research;Educational Curriculum;ethnic diversity;ethnic minority population;Evaluation;evidence base;Evidence based intervention;Evolution;experience;Face;Fostering;Funding;Goals;Health;Health Campaign;health care delivery;health care service;health equity;health inequalities;Health Occupations;Health Sciences;improved;Individual;innovation;Institution;interest;Intervention;Investments;Knowledge;Latinx;Lead;Learning;Maintenance;marginalized population;matriculation;Medical Students;member;Mentors;Mentorship;Methods;Minority Groups;minority health;National Institute of Drug Abuse;new product development;next generation;Nicotine Dependence;nicotine treatment;outcome disparities;Patient Care;patient engagement;Patient-Focused Outcomes;patient-level barriers;Peer Review;Positioning Attribute;premature;programs;Psychology;public trust;Publications;Qualifying;Race;Racial Equity;racial minority;reduce tobacco use;Research;Research Project Grants;Research Training;resilience;Resources;responsible research conduct;retention rate;Scholars Program;Science;Scientist;Signal Transduction;skill acquisition;skills;smoking prevalence;social;social media;Social Sciences;Social Work;Societal Factors;Strategic Planning;structural determinants;Subgroup;symposium;Targeted Research;Time;Tobacco;Tobacco Dependence;Tobacco Industry;tobacco prevention;tobacco products;Tobacco use;Tobacco Use Cessation;Traineeship;Training;Training Programs;Translational Research;Translations;Treatment Effectiveness;Underrepresented Populations;University of Texas M D Anderson Cancer Center;web site;Woman

PROJECT_TITLE: Supporting Tobacco-Related Ongoing Education and Research (STRONGER) Scholar Program

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The Mayo Clinic Stimulating Access to Research in Residency (StARR) program achieved substantial success in its inaugural round with eight resident-investigators completing or currently active in research training. The program—both in model design, operation, and outcomes—has made important strides in supporting heart (and vascular), lung, hematologic (blood), and sleep (HLBS) disorders/diseases research training and career development, building a solid and sustainable research career pipeline. In our next cycle, we will continue to enhance the Mayo Clinic StARR program by extending opportunities to residents in Laboratory Medicine and Pathology and adding experienced preceptors from the same department, and by invigorating recruitment and training to residents from diverse backgrounds.

PI_NAMEs: GAROVIC, VESNA D (contact);NATH, KARL A.

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Address;Adolescent Medicine;Advisory Committees;Basic Science;Blood;Blood Vessels;Cardiovascular Diseases;career;career development;Clinic;Clinical Sciences;Communities;Competence;COVID-19 pandemic;Cultural Backgrounds;Decision Making;design;Discipline of obstetrics;Disease;Education;education research;Educational Background;effectiveness evaluation;Ensure;Environment;equity, diversity, and inclusion;Evaluation;evidence base;experience;Faculty;Feedback;Foundations;Funding;Future;Goals;Growth;Gynecology;Healthcare;Heart;Heart Diseases;Hematological Disease;Hematology;Human Rights;improved;Institution;Internal Medicine;investigator training;Laboratories;Leadership;Lesbian Gay Bisexual Transgender Queer;Lung;Lung Diseases;matriculation;medical specialties;Medicine;men;Mentors;Mentorship;Minnesota;model design;Modeling;multidisciplinary;National Heart, Lung, and Blood Institute;operation;Operative Surgical Procedures;Outcome;Participant;Pathology;Pathway interactions;Pediatrics;Physicians;Principal Investigator;Productivity;Program Development;Program Evaluation;programs;Recording of previous events;Records;recruit;Research;research in practice;Research Infrastructure;Research Personnel;Research Training;Residencies;Resources;retention rate;scaffold;Science;Scientist;Sleep;Sleep Disorders;Solid;Standardization;Structure;Students;success;Talents;Teacher Professional Development;Training;Training Programs;Translating;Translational Research;Vocational Guidance;Woman

PROJECT_TITLE: Mayo Clinic StARR Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (O2)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Relevance to Public Health: We will test the hypothesis that glioblastoma-secreted GABA contributes to the immunosuppressive tumor environment. The results will provide new insights into the glioblastoma biology and suggest new therapeutic approaches.

PI_NAMEs: KAUFMAN, DANIEL  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adult;Affect;Agonist;angiogenesis;antagonist;Anti-Inflammatory Agents;Antitumor Response;Astrocytes;Autoimmune Diseases;autoreactive T cell;B-Lymphocytes;Biology;Brain;Brain Neoplasms;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Line;Cell Physiology;Cell Proliferation;Cell secretion;Cells;Cellular biology;Chloride Channels;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Cytometry;cytotoxicity;Dendritic Cells;design;Disease Progression;effective therapy;Effectiveness;effector T cell;Environment;Enzymes;Extracellular Space;Foundations;Frequencies;Future;GABA Receptor;GABA transporter;GABA-A Receptor;gamma-Aminobutyric Acid;Gene Expression;Glioblastoma;Glioma;Glutamate Decarboxylase;Goals;high dimensionality;Histology;Homologous Gene;Human;Immune;immune cell infiltrate;Immune response;Immune system;Immune Targeting;Immunocompetent;immunogenic;immunogenicity;Immunohistochemistry;Immunosuppression;Immunotherapeutic agent;Implant;improved;in vivo;Individual;Infiltration;Inflammatory;insight;Insulin-Dependent Diabetes Mellitus;interest;Investigation;Ions;Laboratories;Lentivirus;Location;Macrophage;Malignant Neoplasms;Mean Survival Times;Mediating;Membrane;Metabolism;Microglia;Modeling;mouse model;Multiple Sclerosis;Mus;Mutation;Natural Killer Cells;Nature;neoplastic cell;Neurotransmitters;novel strategies;novel therapeutic intervention;novel therapeutics;Patients;Peripheral;Phenotype;Protein Isoforms;Public Health;Resistance;Rheumatoid Arthritis;Role;Sampling;Signal Pathway;Solid Neoplasm;stemness;synthetic enzyme;System;T cell response;T cell therapy;T-Lymphocyte;Testing;transcriptome sequencing;tumor;Tumor Burden;tumor heterogeneity;tumor microenvironment;tumor-immune system interactions;Tumor-infiltrating immune cells;Work

PROJECT_TITLE: Glioblastoma-secreted GABA contributes to the immunosuppressive environment


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative Our expected outcomes will validate an efficient and safe mouse model of brown fat targeting. Due to the vast effects of brown fat in physiology, this mouse model is anticipated to be widely used by scientists in an array of fields with implications in multiple NIH institutes. This is expected to have a positive impact because these mice will be a step forward towards better preclinical research outcomes.

PI_NAMEs: SANCHEZ-GURMACHES, JUAN  (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Address;Adipocytes;Affect;animal model development;Biology;Body System;Brown Fat;Chromosome 1;Chromosome Mapping;Communities;Craniofacial Abnormalities;Cre driver;CRISPR/Cas technology;Crossbreeding;Data;Death Rate;Development;Disease;Effectiveness;Energy consumption;Enterobacteria phage P1 Cre recombinase;experience;Fatty acid glycerol esters;Funding;Gene Expression;Genes;Genetic;Genetic Models;genome editing;genome sequencing;Genomics;Goals;Homeostasis;Human;innovation;interdisciplinary approach;interest;Laboratories;Location;Mediating;Metabolic Control;metabolic phenotype;Modeling;Modification;Molecular;mouse Cre recombinase;mouse model;Mouse Strains;Mus;Outcome;Outcomes Research;Physiological;Physiology;pre-clinical;Pre-Clinical Model;pre-clinical research;Production;promoter;repository;Research;Research Personnel;Resolution;Resources;Role;Scientist;side effect;Signaling Molecule;Site;Source;Specificity;Survivors;System;Techniques;Testing;Therapeutic;tool;Transgenes;Transgenic Animals;United States National Institutes of Health;virtual;whole genome;Wild Type Mouse

PROJECT_TITLE: A validated mouse model of brown fat targeting

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Microbiome;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: NARRATIVE Colorectal cancer (CRC) mortality is markedly higher in African-American patients than any other racial or ethnic group. This proposal aims to understand how tumor metabolites and microbiome differ between racial/ethnic populations, how socioeconomic status effects this association, and potentially impacts patient outcomes. The long-term goals of this research are to determine microbiome and metabolic differences between patients with CRC that can be exploited to improve treatment and reduce mortality.

PI_NAMEs: JOHNSON, CAROLINE HELEN (contact);KHAN, SAJID A

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Address;Affect;African American;African American population;American;Area;Automobile Driving;Basic Science;biological sex;Biology;Body mass index;cancer care;cancer diagnosis;cell growth;Characteristics;chemotherapy;Clinical;Clinical Data;Clinical Treatment;Clinical Trials;cohort;Colon;colon cancer patients;colon microbiome;Colorectal;Colorectal Cancer;colorectal cancer progression;colorectal cancer treatment;comorbidity;Data;Death Rate;Development;Diagnosis;Diet;Disparity;environmental chemical;Environmental Exposure;Environmental Risk Factor;ethnic difference;Ethnic Origin;Ethnic Population;Exposure to;fecal microbiome;Feces;Freezing;Frequencies;Future;Gene Expression Regulation;Generations;genotoxicity;Goals;Growth;Health Services Accessibility;Health system;Immune response;improved;indexing;Individual;Investigation;Knowledge;lifestyle factors;Link;Location;Malignant Neoplasms;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;metabolome;metabolomics;metagenome;microbial;Microbiology;microbiome;microbiome research;microbiota;Modeling;Molecular;Molecular Target;mortality;Mutation;neoplastic cell;Not Hispanic or Latino;novel;Nutrient Depletion;Operative Surgical Procedures;Outcome;Pathway Analysis;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Physical activity;Predisposition;Primary Neoplasm;Production;prospective;Quality of Care;Questionnaires;Race;racial difference;racial population;Research;Resected;Sampling;sex;Social Adjustment;social health determinants;social influence;social vulnerability;Socioeconomic Factors;Socioeconomic Status;Source;stool sample;Stratification;stressor;survival disparity;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Time;Tissue Sample;Tissues;Treatment Efficacy;Treatment Protocols;treatment response;tumor;tumor metabolism;tumor microbiome;tumor progression;Tumor Tissue;United States;uptake

PROJECT_TITLE: Identification of metabolic niches in African Americans with colorectal cancer

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ORG_CITY: GALVESTON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE There is a great need to understand the mechanisms of lung disease and innate antiviral immunity in RSV infections during early life. We propose to investigate how IFNs that are packaged in subcellular fractions released by infected cells function as antiviral innate mediators against RSV, with the long-term plan to develop new strategies for the delivery of immune factors to the lung.

PI_NAMEs: GAROFALO, ROBERTO P (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: 5 year old;Acute;Age;airway epithelium;airway inflammation;Animal Experimentation;Anti-viral Response;antiviral immunity;Area;Asthma;autocrine;Biological;Biological Assay;Biological Models;Biological Process;Biological Response Modifiers;Cell Communication;Cell Physiology;Cells;Cessation of life;Characteristics;Child;Chronic Obstructive Pulmonary Disease;Clinical Research;cohort;Collaborations;college;Communication;Core Facility;cytokine;cytosolic receptor;Data;Detection;Developmental Delay Disorders;Disease;Disease Progression;Distant;DNA;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Epithelium;Escalator;Experimental Animal Model;Experimental Models;extracellular vesicles;Future;Gene Expression;Generations;glycoprotein G;GTP-Binding Proteins;Guidelines;Hospitalization;Human;Immune;Immune response;Immunoassay;Immunologic Factors;in vivo;Infant;infant infection;Infection;Inflammation;Infrastructure;inhibitor;Innate Immune System;Institutional Review Boards;Interferons;International;Investigation;Knowledge;Laboratories;Life;Lipids;Lower respiratory tract structure;Lung;Lung Diseases;Mediating;Mediator;Membrane;Messenger RNA;Methods;Modeling;Nasopharynx;Nose;novel;Nucleic Acids;Organoids;particle;Pathogenesis;Pathway interactions;Patients;pharmacologic;Play;Process;Property;Proteins;Publishing;Research Personnel;Respiratory Disease;Respiratory Mucosa;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Tract Diseases;respiratory virus;response;RNA;Role;Severities;Severity of illness;Shapes;Signal Transduction;Site;Societies;State Medicine;Structure;Structure of mucous membrane of nose;Subcellular Fractions;System;Techniques;Testing;Travel;Upper respiratory tract;Vaccines;vesicular release;Viral;Viral Genes;Viral Load result;Viral Physiology;Viral Respiratory Tract Infection;Virus;Work

PROJECT_TITLE: Extracellular Vesicles (EVs) Innate Immune Cargo in Respiratory Viral Infections

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: WORCESTER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project narrative. Pulmonary tuberculosis, the disease caused by Mycobacterium tuberculosis, is a threat to global health. This research proposal seeks understand how altered states of immunity or concurrent infection impairs host resistance to TB.

PI_NAMEs: BEHAR, SAMUEL M (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Acceleration;Address;Affect;Africa South of the Sahara;Allergic Disease;Antibodies;Area;Asthma;Attenuated;Automobile Driving;Bacille Calmette-Guerin vaccination;Breeding;C57BL/6 Mouse;cell type;Cells;Cessation of life;Child;Chronic;Clinical;Clinical Data;clinically relevant;Communities;Country;cytokine;Disease;Drug resistant Mycobacteria Tuberculosis;Environment;eosinophil;epidemiologic data;Gene Expression Profiling;Genetic;Genetic Predisposition to Disease;Genetic Variation;Genotype;Genus Mycobacterium;global health;Growth;helminth infection;Helminths;Host resistance;Human;Immune;Immune response;Immunity;Immunologics;Immunologist;Impairment;in vivo;Inbred Strain;Inbred Strains Mice;Inbreeding;Infant;Infection;insight;Interleukin-13;Interleukin-4;Interleukin-5;Knowledge;Laboratory mice;Link;Lung;Lung Diseases;Macrophage Activation;Maps;mast cell;Measures;Mediating;Modeling;mouse model;Mouse Strains;Mus;Mycobacterium bovis;Mycobacterium Infections;Mycobacterium tuberculosis;Parasites;Pathogenesis;Persons;Phenotype;Population;Predisposition;prevent;Production;Pulmonary Tuberculosis;Recombinants;Regulation;Regulatory T-Lymphocyte;Research;Research Proposals;response;Role;Scheme;School-Age Population;segregation;Signal Transduction;single-cell RNA sequencing;Susceptibility Gene;Testing;Th2 Cells;therapeutic evaluation;tool;Translating;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;vaccine-induced immunity;Vaccines

PROJECT_TITLE: The impact of IL-4 and IL-4-producing cells on protective immunity to tuberculosis

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: FORT WORTH

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

PHR: NARRATIVE  This program will address the significant gap in the number of underrepresented minority groups, disadvantaged populations and individuals with disabilities that enter biomedical and behavioral science careers. This program will provide undergraduate students interested in pursuing NIDA-related research, a 10- week summer research experience in a mentor-guided laboratory. The expectation is an increase in the number of diverse and highly motivates students attaining biomedical degrees in the biomedical and behavioral sciences.

PI_NAMEs: JONES, HARLAN PIERRE (contact)

PROGRAM_OFFICER_NAME: FRIEND, LINDSEY NICOLE

PROJECT_TERMS: academic intervention;Academic skills;Affect;Area;Awareness;Behavioral Sciences;Biomedical Research;career;cohort;college;combat;Complement;Decision Making;Disabled Persons;disadvantaged background;Disparity population;Drug Addiction;Enrollment;Ensure;Environment;expectation;experience;Exposure to;Faculty;Female;Fostering;Goals;graduate school;graduate student;Health;Health Sciences;Home;Illicit Drugs;Individual;Infrastructure;Institution;interest;Internships;Knowledge;Laboratories;learning community;Link;Mentors;Minority Groups;Mission;Motivation;National Institute of Drug Abuse;Overdose;peer;Pharmaceutical Preparations;Positioning Attribute;prescription opioid;Program Description;Program Sustainability;programs;recruit;Reporting;Research;research faculty;Research Project Grants;Research Training;Resources;Risk;skills;Social Network;Student Persistence;Students;Substance abuse problem;Substance Addiction;summer research;symposium;Texas;Training;undergraduate research;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Center for Health Statistics;United States National Institutes of Health;Universities;virtual;Youth

PROJECT_TITLE: Summer Undergraduate Research Internship Program


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: SALT LAKE CITY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative The proposed research is relevant to public health because it focuses on developing new, non-invasive methods to identify individuals at high risk of cardiac disease, including sudden cardiac death (SCD). Once developed, such testing could lead to more efficient screening and earlier intervention, with a subsequent reduction in adverse clinical events. The project is relevant to the part of NIH’s mission that pertains to developing new methodology, and reducing morbidity.

PI_NAMEs: STEINBERG, BENJAMIN ADAM;TASDIZEN, TOLGA  (contact)

PROGRAM_OFFICER_NAME: HSU, LI-YUEH

PROJECT_TERMS: adversarial learning;Algorithms;Architecture;arrhythmogenic cardiomyopathy;Automobile Driving;Cardiovascular Diseases;Classification;classification algorithm;Clinical;clinical care;clinical development;clinical phenotype;clinical predictors;Clinical Sciences;clinically actionable;Communities;cost effective;Data;Data Set;deep neural network;Detection;Development;digital health;Disease;Early Intervention;Electrocardiogram;Environment;Equity;Event;Exclusion;explainable machine learning;Funding Opportunities;Genotype;Goals;heart disease risk;high risk;Human;Impairment;improved;Individual;innovation;insight;Knowledge;Label;large datasets;Lead;Left Ventricular Ejection Fraction;Link;Machine Learning;machine learning algorithm;machine learning classification;machine learning method;machine learning model;Methodology;Methods;Mission;model development;Modeling;Morbidity - disease rate;mortality;Multicenter Studies;novel;Outcome;Pathogenicity;Patient Care;Patients;Pattern;Physiological;Population;Potassium;prediction algorithm;prevent;Prevention;Property;Public Health;Research;Science;screening;secondary analysis;self supervised learning;Signal Transduction;Source;success;sudden cardiac death;System;Techniques;Testing;tool;Training;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Overcoming explainability and data availability barriers to broad application of ECG ML screening with a system-wide ECG dataset

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Data Science;Dementia;Genetics;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative In this proposal, we will harmonize several large longitudinal datasets in AD, identify DNA methylation differences associated with cognitive reserve, and develop DNA methylation biomarkers for predicting AD. The successful completion of this project will provide us with an inexpensive and convenient approach for identifying subjects most likely to progress to clinical AD, harmonized datasets and open-source computational tools for AD research, and advance our understanding of the epigenetic architecture underlying cognitive reserve.

PI_NAMEs: WANG, LILY  (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: Aging;aging biomarker;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-42;Architecture;Baltimore;Biological Markers;Blood;Brain;Clinical;Clinical Data;Clinical Trials;cognitive function;cognitive reserve;Communities;computerized tools;Computing Methodologies;Data;data harmonization;data integration;Data Set;Dementia;design;Development;Diet;Disease;Disease Outcome;DNA Methylation;Environment;Epigenetic age;Epigenetic Process;Exercise;Family;follow-up;Framingham Heart Study;Genes;Genetic Markers;Genome;Goals;Health and Retirement Study;Health Care Costs;Heterogeneity;high risk;Image;Impaired cognition;improved;Individual;innovation;Knowledge;Life Style;lifestyle factors;lifestyle intervention;longitudinal dataset;Longitudinal Studies;methylation biomarker;minimally invasive;Modeling;Multi-Ethnic Study of Atherosclerosis;multiple datasets;Names;Nerve Degeneration;neuroimaging;new therapeutic target;open source;Outcome Measure;Pathology;Pathway interactions;Patient Selection;personalized medicine;personalized strategies;Persons;Phase;Plasma;Play;precision medicine;predictive marker;predictive modeling;prevent;Prevention strategy;Process;Public Health;Research;Risk;Risk Reduction;Role;Sample Size;Sampling;Smoking;Societies;Source;Testing;Time;Training;treatment strategy;Variant

PROJECT_TITLE: New DNA methylation biomarkers for predicting AD and cognitive decline

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-S (15)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NORTH CHICAGO

ORG_NAME: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI

ORG_STATE: IL

PHR: NARRATIVE This proposal will utilize mice expressing human APP to investigate the effects of Nep-like enzymes in the acute response to traumatic brain injury (TBI) and the subsequent chronic development of Alzheimer’-like pathology. L

PI_NAMEs: MARR, ROBERT ANTHONY (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: abeta accumulation;Abeta clearance;Acute;Address;Affect;Alzheimer like pathology;Alzheimer's Disease;Amyloid beta-Protein;Anxiety;Behavior assessment;Behavioral;Brain;Cell Death;Cerebrum;Chronic;chronic traumatic encephalopathy;Cognitive deficits;cognitive function;Data;Dementia;dementia risk;Development;effective therapy;Endopeptidases;Environmental Risk Factor;enzyme activity;Enzyme Inhibition;Enzyme Inhibitor Drugs;Enzymes;Event;FarGo;FDA approved;follow-up;Future;Genetic;glial activation;Goals;Head;Homologous Gene;Human;Impaired cognition;Individual;inhibitor;Injury;Laboratories;Laboratory Finding;Learning;Link;Memory;Molecular;morris water maze;Motor;Motor Activity;motor deficit;mouse model;Mus;Neprilysin;Nervous System Physiology;novel;object recognition;Pathologic;Pathology;Pathway interactions;Peptides;Pharmaceutical Preparations;pharmacologic;phosphoramidon;preclinical development;Process;Protocols documentation;Publishing;Reporting;response;Risk Factors;Role;Route;tau Proteins;tau-1;TBI treatment;Testing;Therapeutic;therapeutic development;therapeutic evaluation;Time;Transgenic Mice;Traumatic Brain Injury;Traumatic Brain Injury recovery;Traumatic brain injury related dementia;Work

PROJECT_TITLE: Pharmacological inhibition of NEP-like enzymes in traumatic brain injury and dementia

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

PHR: Project Narrative Chronic infection with hepatitis B virus (HBV) presents a global public health burden affecting 296 million individuals worldwide, who are at high risk of developing severe liver diseases, including cirrhosis and hepatocellular carcinoma. Our proposed research seeks to explore the distinct functions of the HBV PreCore- derived proteins in modulating the outcome of HBV infection, as well as to identify their associated host factors and dynamic changes related to infection outcome and antiviral treatment. Our project will characterize new virus-host interactions linked to viral persistence and their use as a potential biomarker predicting HBV infection and treatment outcomes.

PI_NAMEs: HU, JIANMING ;MENNE, STEPHAN  (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Acute;Acute Hepatitis;Adult;Affect;age related;analog;Animal Model;Anti-viral Agents;Antibodies;Antigens;Apolipoproteins;Blood;cesium chloride;Cessation of life;Chronic;Chronic Hepatitis;Chronic Hepatitis B;chronic infection;Cirrhosis;Co-Immunoprecipitations;cohort;curative treatments;density;Development;dimorphism;e Antigens;Enzymes;exosome;extracellular vesicles;Fractionation;gene function;gene product;Genes;Hepatitis B Infection;Hepatitis B Virus;Hepatitis Viruses;Hepatocarcinogenesis;Hepatocyte;high risk;Histopathology;Human;Immune response;Individual;Infection;Integration Host Factors;Interferon alpha;iodixanol;Link;Lipids;Lipoproteins;Liver;liver biopsy;Liver diseases;Measurement;Measures;mutant;Names;neonate;novel;Nucleotides;Outcome;Pan Genus;Patients;Peptide Signal Sequences;Persons;Plasmids;Point Mutation;Population;Population Density;Positioning Attribute;potential biomarker;predictive marker;Predisposition;Primary carcinoma of the liver cells;Proteins;Public Health;Research;response;RNA;Role;Sampling;Sedimentation process;Serum;Severities;Study models;T cell response;Time;Transfection;Treatment outcome;Viral;Viral Antigens;viral DNA;Viral Genes;Viral Genome;Viral hepatitis;Virus Diseases;virus host interaction;Virus Replication;Woodchuck;Woodchuck Hepatitis B Virus

PROJECT_TITLE: Exploring Hepatitis B Virus PreCore Gene Functions in Woodchucks

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]