NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Astrocytes establish a functional network system through conduit proteins, termed gap junctions, to participate in brain function. This proposal is expected to provide novel insights into the physiological operation of this glial network system through crosstalk with neuronal signalings. By examining astrocyte function at a biologically higher hierarchy, a networking system level, the results are expected to shed light on the still mysterious function of astrocytes, and also establish dataset for further examination of the potential etiological link between dysfunctional astrocyte networks and neurological disorders.

PI_NAMEs: ZHOU, MIN  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acute;Adrenergic Receptor;Astrocytes;Biological;Brain;Brain Injuries;Chemosensitization;Clozapine;Connexin 43;Coupled;Coupling;Data;Data Set;Dependence;designer receptors exclusively activated by designer drugs;Disease;Dissociation;dosage;Dose;Electrophysiology (science);Etiology;Foundations;functional plasticity;gap junction channel;Gap Junctions;genetic manipulation;Giant Cells;Glutamate Transporter;glutamatergic signaling;Glutamates;Hippocampus;Homeostasis;Impairment;In Situ;infancy;insight;Knock-out;Link;LoxP-flanked allele;Mediating;Mediator;Methods;Molecular;Mus;Mutant Strains Mice;Nervous System Disorder;neuronal excitability;Neurons;neurotransmission;Norepinephrine;novel;operation;patch clamp;pharmacologic;Physiological;Potassium;Potassium Channel;Proteins;Regulation;Research;response;Role;Series;short-term potentiation;Signal Induction;Signal Pathway;Signal Transduction;Slice;Synaptic Transmission;System;Testing;transmission process;Work

PROJECT_TITLE: Functional plasticity of astrocyte syncytial network

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Obesity is associated with “metabolic inflexibility”, which is involved in the pathophysiology of obesity-induced metabolic abnormalities, such as type 2 diabetes and insulin resistance. The proposed studies aim to understand the mechanisms of obesity-induced metabolic flexibility and develop new obesity treatment by using genetically engineered mouse models, cell culture system, and human adipose tissue biopsy samples.

PI_NAMEs: KLEIN, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Acetylation;Adipocytes;Adipose tissue;Adrenergic Agents;Anabolism;Biology;Biopsy Specimen;Blood specimen;Body Weight decreased;Calories;caveolin 1;Cell Culture System;Clinical;clinically relevant;Coenzymes;Data;Dependovirus;Diet;dietary restriction;Energy Metabolism;Enhancers;Enzymes;Exercise;exercise training;feeding;flexibility;Foundations;Functional disorder;Funding;Genetic;Genetically Engineered Mouse;glucose metabolism;Grant;High Fat Diet;Human;Impairment;improved;In Vitro;indexing;insight;Insulin Resistance;insulin sensitivity;insulin signaling;Knockout Mice;Life Style Modification;Link;Liver;Lysine;Mediating;Mediator;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Molecular;mouse model;Mus;Nicotinamide adenine dinucleotide;Nicotinamide Mononucleotide;nicotinamide phosphoribosyltransferase;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;Obesity;obesity treatment;Organ;overexpression;Overweight;Oxidation-Reduction;Persons;pharmacologic;Physiological;Placebos;PPARG gene;Prediabetes syndrome;response;Risk;Rodent;Series;Sirtuins;Skeletal Muscle;Supplementation;System;Tamoxifen;Testing;therapeutic target;Thermogenesis;Tissues;Visceral

PROJECT_TITLE: NAD+ and metabolic flexibility

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Obesity is one of the most complex public health challenges facing the United States, and population-level approaches to prevention are necessary to combat it. This proposal examines the impact of a promising policy, sugary beverage taxes, on calories purchased in fast food restaurants.

PI_NAMEs: ELBEL, BRIAN  (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Adopted;Adult;Area;Beverages;Budgets;Calories;Cardiovascular Diseases;Censuses;Characteristics;Cities;combat;Communities;comparison group;competitive environment;Complex;Consumption;Data;density;design;Diabetes Mellitus;Effectiveness;Ensure;environmental change;Ethnic Origin;Evaluation;fast food;Food;Funding;Goals;Health;health disparity;High-Income Populations;Household;Income;Individual;interest;Location;Low income;Malignant Neoplasms;Modeling;Nature;Neighborhoods;Obesity;Outcome;Policies;Population;Prevalence;Prevention approach;Price;Public Health;Public Policy;Race;Recommended Daily Allowances;Research;response;Restaurants;Role;Sales;Source;sugar;Supermarket;sweetened beverage;Taxes;United States;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: The Influence of Sugary Beverage Taxes on Fast Food Restaurant Purchases: An Evaluation Using National Sales Data

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: PILLINGER, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: DOYLE, JAMIE MIHOKO

PROJECT_TERMS: Address;Advisory Committees;career;Career Choice;career development;Clinical;Clinical Research;cohort;Dedications;Development;Doctor of Philosophy;Doctor's Degree;Educational Status;Ensure;expectation;experience;Exposure to;Faculty;Funding;Goals;Grant;improved;innovation;Institution;Investments;Manuscripts;meetings;Mentors;multidisciplinary;next generation;Performance;Postdoctoral Fellow;Preparation;Process;Program Development;programs;Publications;recruit;Research;Research Personnel;Research Project Grants;Research Training;responsible research conduct;Science;Scientist;Site;skills;symposium;tool;Training;translational impact;Translational Research;translational research program;translational scientist;Vision;Work;working group

PROJECT_TITLE: Institutional Career Development


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The collateral tissue damage that results from an immune response can cause life-threatening maladies that are sometimes more dangerous than the infection itself. Our research proposal sets out to understand the means by which an immune response is set into motion. By focusing our work on the earliest triggers of immune activation (the detection of microbes) we may unravel new means by which we can control the activation or inactivation of immunity.

PI_NAMEs: KAGAN, JONATHAN C (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: adaptive immunity;aerobic glycolysis;Antitumor Response;Biology;cancer immunotherapy;CD14 Antigen;CD8-Positive T-Lymphocytes;Cells;Complex;Curiosities;Dangerousness;Data;Dedications;Dendritic Cells;Detection;Enzymes;Event;Family;Funding;Gene Expression;Genetic Transcription;Glycolysis;Glycolysis Induction;Glycolysis Pathway;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;immune activation;Immune response;Immunity;In Vitro;in vitro activity;Infection;Inflammatory;innate immune pathways;innovation;Interferons;Investigation;Knowledge;Life;Macrophage;Malignant Neoplasms;MAP Kinase Gene;Medial;Mediating;Metabolic;Microbe;Motion;Mus;NF-kappa B;novel;Pathway interactions;Phosphotransferases;Proteins;receptor;Receptor Signaling;recruit;Regulation;Research Proposals;response;Role;scaffold;Signal Pathway;Signal Transduction;Site;Structure;synthetic biology;System;T-Lymphocyte;TBK1 gene;Tissues;TLR3 gene;TLR4 gene;Toll-Like Receptor Pathway;Toll-like receptors;TRAF6 gene;transcription factor;Tumor Antigens;Tumor Immunity;Work

PROJECT_TITLE: Defining the pathways activated by Toll-like Receptors to stimulate immunity

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Long-term immunity and the formation of protective memory B and T cells are necessary to survive deadly pandemics, as currently evidenced by COVID-19. Several transcriptional and epigenetic factors have been discovered that control the formation of diverse types of memory T cells, but we know very little about how these factors are targeted within the genome to control gene expression and specify T cell differentiation states. This proposal seeks to discover how BAF complexes, critical nucleosome remodelers, control the transcription factor networks that underlie effector and memory T cell development.

PI_NAMEs: KAECH, SUSAN M (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Address;Adopted;Aging;Antigens;ARID1A gene;Autoimmunity;Binding;Binding Sites;CD8-Positive T-Lymphocytes;Cell Differentiation process;cell motility;Cell Physiology;Cells;Cellular biology;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chronic;Chronic Disease;Communicable Diseases;Complex;COVID-19;COVID-19 pandemic;Cutaneous T-cell lymphoma;cytotoxic;Data;DNA;DNA Binding;Drug Design;Drug Targeting;Effector Cell;effector T cell;Enhancers;Epigenetic Process;Exposure to;fighting;Foundations;frontier;future pandemic;Gene Expression;Gene Expression Profile;Genetic;Genetic Transcription;Genome;Goals;Grant;Hematological Disease;Histones;Host Defense;Immunity;Immunologic Memory;Immunotherapy;in vivo;Infection;Inflammation;ISWI;Knowledge;Malignant lymphoid neoplasm;Malignant Neoplasms;Maps;Memory;Memory B-Lymphocyte;migration;Molecular;Mutate;Nucleosomes;pandemic disease;pathogen;Pathway interactions;Pattern;Play;Population;precursor cell;promoter;recruit;Recurrence;Regulation;Role;Signal Transduction;Site;SMARCA4 gene;Specific qualifier value;Specificity;Study models;SWI/SNF Family Complex;System;T cell differentiation;T cell response;T memory cell;T-Cell Activation;T-Cell Development;T-Lymphocyte;transcription factor;Transcriptional Regulation;Vaccines;Virus Diseases

PROJECT_TITLE: Regulation of memory CD8 T cell development

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: TALLAHASSEE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Microtubules constitute a major cytoskeletal network required for many diverse and critical cellular functions such as structural support, molecular and vesicle trafficking, etc, that is coordinated from specific organizing centers that vary according to cell type and which serve the unique functions of those cell types. The goals of this proposal are to determine the mechanisms by which one specific and critical microtubule-organizing center (MTOC) functions, and to define new paradigms for microtubule assembly that have emerged from this project and are expected to broadly impact physiology, disease, and development.

PI_NAMEs: MEGRAW, TIMOTHY L (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TITLE: Mechanisms of non-centrosomal microtubule-organizing center functions

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Endocrine Disruptors;Foodborne Illness;Prevention;Social Determinants of Health

ORG_CITY: NEWTON

ORG_NAME: GINER, INC.

PHR: Project Narrative Giner, Inc. will develop a portable, accurate, rapid-response, versatile, and affordable field instrument for monitoring human environmental exposure to multiple heavy metals. This work will focus on rapid testing of urine samples with high accuracy. A low-cost, on-site instrument will enable near real-time monitoring of heavy metal exposures in at-risk populations and better attending to the technical and practical needs of epidemiologists.

PI_NAMEs: ARGUN, AVNI A (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Acceleration;Acute;analytical method;Area;Arsenic;Assessment tool;bioaccumulation;Biological Assay;Biological Markers;Blood;Body Fluids;Cadmium;Chronic;Clinical;Collaborations;commercialization;Communities;Community Health;Complex;Computer software;computerized data processing;contaminated drinking water;cost;cost effective;Country;Coupled;data quality;data tools;design;Detection;detection limit;detection method;Development;diagnostic technologies;Disease;disorder prevention;drinking water;Electronics;Ensure;Environment;Environmental Exposure;Environmental Health;Environmental Pollutants;Epidemiologist;Epidemiology;epidemiology study;Equipment;Evaluation;experience;exposed human population;Exposure to;fabrication;field study;Food;Freezing;Goals;Health;health science research;healthcare community;Heavy Metals;High Pressure Liquid Chromatography;Human;human subject;human tissue;improved;Industrialization;Ingestion;Inhalation;Institution;instrument;interest;International;Investments;Lab On A Chip;Laboratories;Lead;Letters;Liquid substance;Manganese;Mass Spectrum Analysis;Measurement;Measures;Medical;medical schools;Metal exposure;metal poisoning;Metals;Methods;Microfluidic Microchips;Microfluidics;Monitor;next generation;operation;Outcome;Performance;Phase;Physiological;Plasma;Population;Populations at Risk;portability;portable monitoring;Prevalence;prevent;programs;prototype;Public Health;Public Health Schools;rapid testing;Reagent;real time monitoring;Research Personnel;Resolution;response;Risk;Safety;Sampling;Science;Scientist;screening;sensor;sensor technology;Series;Site;skills;Soil;Source;Specialist;superfund site;System;Technology;Testing;Time;tool;Toxic effect;toxic metal;Trace metal;Training;Transportation;Universities;urinary;Urine;usability;Validation;Vial device;Water;Work

PROJECT_TITLE: Field Instrument for Assessment of Arsenic Exposure


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Back Pain;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: PITTSBURGH

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Neuropathic pain is a common debilitating disease with no effective treatments. We propose that peripheral nerve injury engages a novel pain pathway in the spinal cord. Interrogation of this pathway could lead to the development of a new non-opioid neuropeptide-based pharmacotherapy for neuropathic pain.

PI_NAMEs: TAYLOR, BRADLEY K. (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Ablation;Action Potentials;Address;Affective;Agonist;allodynia;Analgesics;Anatomy;Behavior;Behavioral;Budgets;Cells;Characteristics;Chemosensitization;Cholecystokinin;chronic pain;conditional knockout;Confocal Microscopy;Coupled;Data;Data Set;Development;Disease;Dorsal;dorsal horn;effective therapy;Electrophysiology (science);Elements;Excitatory Synapse;Fiber;Frequencies;Gastrin releasing peptide;Genetic;Glutamates;Goals;GRP gene;immunoreactivity;in vivo;Inhibitory Synapse;Interneurons;Measures;Mechanics;Mediating;Messenger RNA;Modeling;Morphology;Mus;nerve injury;Neurobiology;neuronal circuitry;Neurons;neuropeptide FF;neuropeptide Y;neuropeptide Y-Y1 receptor;Neuropeptides;non-opioid analgesic;novel;optogenetics;Pain;Pain management;painful neuropathy;patch clamp;Pathway interactions;patient subsets;Pattern;Peripheral nerve injury;pharmacologic;Pharmacotherapy;Posterior Horn Cells;postsynaptic;presynaptic;Presynaptic Terminals;prevent;Protein Inhibition;Protein Kinase C;protein kinase C gamma;Proxy;receptor;recruit;Reflex action;Reporter;Reporting;Resolution;Rodent Model;Role;Slice;spared nerve;Spinal;Spinal Cord;Spinal cord posterior horn;Spine pain;Stimulus;Synapses;Testing;Touch sensation;transcriptome sequencing;transcriptomics;transmission process;voltage clamp;wireless

PROJECT_TITLE: Neuropeptidergic Inhibition of Spinal Pain Transmission

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: When Veterans miss clinic visits, or `no-show', this is considered a type of access failure. A major challenge in improving no-shows has been identifying and intervening on Veterans who frequently miss scheduled clinic appointments. Previous interventions (e.g. reminder phone calls, etc.) have not substantially improved no-show rates. This research will first develop and test the use of a prediction tool that uses patient-level characteristics to assess Veterans' propensity to miss clinic visits. Then, after obtaining feedback from Veterans at-risk of missing clinic appointments, we will use VA Video Connect (VVC; a newly developed telemedicine-based application that allows Veterans to interact with their VA health care providers using their smartphone, tablet, or computer) as an alternative means of obtaining primary care. This proposal aims to improve access by making it easier for at-risk Veterans to have clinic visits with their VA providers using VVC. The use of VVC in at-risk sub-populations aims to improve no-show rates, patient and provider satisfaction, and clinic efficiency.

PI_NAMEs: WRAY, CHARLIE M (contact)

PROJECT_TERMS: Address;Appointment;Area;care delivery;career;Caring;Cellular Phone;Characteristics;Classification;Clinic;Clinic Visits;clinical phenotype;cohort;Computers;connected care;cost;Data;design;Devices;effectiveness/implementation design;Elements;Ensure;Environment;Failure;Feedback;formative assessment;Goals;Health Personnel;Health Services Accessibility;Heart failure;high risk;Homelessness;Hospitalization;Housing;Improve Access;improved;innovation;Intervention;Location;machine learning prediction;marginally housed;Measures;Medical;Medical Records;meetings;Mental Health;Methodology;Methods;Modality;Modeling;novel;Online Systems;Outpatients;Patients;Persons;Phenotype;Population;predictive modeling;predictive tools;preference;Primary Care;primary care clinic;Probability;process evaluation;programs;Provider;Quality of Care;Recording of previous events;regression trees;Reporting;Research;Research Personnel;Resources;Risk;Risk Estimate;Risk Factors;risk prediction model;satisfaction;Schedule;Services;Site;social;social vulnerability;structural determinants;Substance abuse problem;Tablets;targeted delivery;Techniques;Technology;telehealth;Telemedicine;Telephone;Testing;Text Messaging;tool;Veterans;Veterans Health Administration;Videoconferencing;Violence;Visit;Voice;Vulnerable Populations;Work

PROJECT_TITLE: Improving Access Through Targeted Delivery of Telemedicine

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: This study will test whether a hand hygiene-based mindfulness intervention can improve provider hand hygiene adherence, improve provider well-being, and enhance Veteran outcomes. Given the importance of hand hygiene adherence and the increasing levels of provider burnout and stress, this work directly aligns with multiple priorities of the Department of Veterans Affairs (VA) and will enhance Veteran safety. Our findings will shed light on how to more effectively prevent infections through the use of a novel mindfulness intervention focused on increasing hand hygiene adherence and provider well-being.

PI_NAMEs: GREENE, MICHAEL TODD (contact);SAINT, SANJAY K

PROJECT_TERMS: Address;Adherence;adherence rate;Adopted;Anxiety;anxiety reduction;Area;Attention;Awareness;burnout;care providers;career;Caring;Client satisfaction;Clinical;clinical practice;Cognitive;Control Groups;cost;COVID-19 pandemic;Decision Making;disease transmission;Education;effectiveness evaluation;Elements;Ensure;Environment;Evidence based practice;experience;Face;falls;Fatigue;Focus Groups;future outbreak;Goals;Hand;health care service organization;health care settings;Health Personnel;Health system;Healthcare;Healthcare Systems;healthcare-associated infections;Hospital Administration;Hospitals;Human Resources;Hygiene;improved;Infection;Infection prevention;innovation;Intervention;Interview;Judgment;Malpractice;Measures;Medical center;member;Mental Depression;Methodology;Methods;mindfulness;mindfulness intervention;multi-component intervention;novel;Nurses;Outcome;patient safety;Patient-Focused Outcomes;Patients;Perception;Personal Satisfaction;Physicians;Pilot Projects;prevent;Provider;provider adherence;Psyche structure;psychological distress;Quality of Care;Quality of life;Randomized;Recommendation;Regulation;Reporting;Risk;Safety;Site;Stress;Structure;success;Symptoms;Techniques;Testing;Time;tool;treatment arm;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Work;Workload

PROJECT_TITLE: Mindful Hand Hygiene to Reduce Infections Among Veterans While Enhancing ProviderWell-Being

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Hydrocephalus;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Rare Diseases;Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Diffuse Optics for Pediatric Hydrocephalus Management Project Narrative Surgical treatment of elevated intracranial pressure (ICP) in hydrocephalus patients is the most common operation performed by pediatric neurosurgeons in the United States. Decision-making about when and if to intervene is hindered by a gap in knowledge about how ventricular enlargement relates to changes in ICP and cerebral blood flow. This research will validate the capabilities of a novel diffuse optical approach for non-invasive detection and prediction of elevated ICP and ischemia in children.

PI_NAMEs: BAKER, WESLEY  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: 2 year old;Affect;Age;aged;arteriole;Biological Markers;Blood Pressure;Brain;Brain Injuries;Caring;cerebral blood volume;cerebral hemodynamics;Cerebral Ischemia;Cerebral Ventricles;Cerebrospinal Fluid;Cerebrovascular Circulation;Cerebrum;Child;Childhood;Clinical;congenital heart abnormality;Data;Decision Making;Detection;Development;Diagnosis;Diffuse;Disease;Etiology;Evaluation;experience;Exposure to;Failure;falls;Family suidae;Goals;Head;Hemorrhage;Hydrocephalus;Image;indexing;Infant;infection risk;Institution;interstitial;Intervention;Intracranial Hypertension;Intracranial Pressure;Ionizing radiation;Ischemia;Judgment;Knowledge;light intensity;Live Birth;Measurement;Measures;Meningomyelocele;Metabolism;Microdialysis;Monitor;multimodal data;multimodality;Names;Neonatal;Neurologic Deficit;Neurological outcome;Neurosurgeon;neurosurgery;Non-Invasive Detection;novel;operation;Operative Surgical Procedures;Optics;Oxygen;Patients;Physiology;porcine model;pressure;prevent;Principal Investigator;Procedures;Proxy;Pyruvate;Research;Risk;Risk Factors;Scientist;Shunt Device;Stenosis;Sum;Techniques;Technology;Time;Toddler;tool;Translating;Translations;United States;Validation;Ventricular;Vulnerable Populations;X-Ray Computed Tomography


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Congenital Muscular Dystrophy;Congenital Structural Anomalies;Genetics;Intellectual and Developmental Disabilities (IDD);Muscular Dystrophy;Orphan Drug;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative This proposal takes advantage of the ability of pluripotent stem cells (PSC) to uniquely produce differentiated somatic cell types in large quantities. We have developed methods, based on the conditional expression of Pax3 and Pax7, to induce the muscle program in early mesoderm, and thus derive muscle progenitors with great efficiency for regenerative medicine and disease modeling. Our investigations will focus on understanding the effect of the environment on the engraftment of PSC-derived myogenic progenitors, and the molecular signature and long-term regenerative potential of control and gene corrected FKRP mutant PSC-myogenic progenitors.

PI_NAMEs: PERLINGEIRO, RITA C. R. (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Address;Affect;Age;Allogenic;Autologous;Biochemical;Biological Assay;Cell Compartmentation;Cell Therapy;Cell Transplantation;cell type;Cells;Chronic;Clinical Trials;Complication;congenital muscular dystrophy;design;Development;disease model;dystroglycanopathy;early onset;Engraftment;Environment;Extracellular Matrix Proteins;Fibrosis;fukutin related protein;Future;gene correction;Generations;Genes;Genetic Diseases;glycosylation;Human;Human Characteristics;human pluripotent stem cell;immunodeficiency;Impairment;In Vitro;in vivo;induced pluripotent stem cell;Injury;Investigation;Limb-Girdle Muscular Dystrophies;MDC1C;Mesoderm;Methods;Molecular;Molecular Profiling;Mononuclear;mouse model;Mus;Muscle;Muscle Fibers;muscle progenitor cell;muscle regeneration;muscle repair;Muscle satellite cell;Muscular Atrophy;Muscular Dystrophies;mutant;Mutation;Myopathy;Natural regeneration;Patients;Play;Pluripotent Stem Cells;Population;post-transplant;progenitor;programs;regeneration potential;Regenerative Medicine;respiratory;Respiratory Diaphragm;response;Role;single-cell RNA sequencing;skeletal;Skeletal Muscle;Somatic Cell;stem cell therapy;Stem cell transplant;Technology;Therapeutic;Therapeutic Effect;tissue degeneration;transcriptome;Transplantation;Walker-Warburg syndrome;α-Dystroglycan

PROJECT_TITLE: Targeting Dystroglycanopathies using Pluripotent-derived Myogenic Progenitors

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Emerging data suggest that β cell extracellular vesicles (EVs, or membrane bound nanoparticles that carry and transfer molecular cargo) may affect other cells in the islet. The goals of this project are: 1) to define how inflammatory stress is linked to changes in the cargo of β cell EVs; 2) determine functional effects of changes in β cell EV cargo on surrounding β cells; and 3) determine whether β cell EV cargo are altered in humans with or at-risk for diabetes. This work will address a critical gap in knowledge regarding β cell EV biology and has the potential to inform novel diagnostic strategies.

PI_NAMEs: SIMS, EMILY K (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Affect;Antibodies;Beta Cell;Binding;Biogenesis;Biological Markers;Biology;Biotin;Blood specimen;Cell Communication;Cell Death;Cell Survival;cell type;Cells;Cellular Stress;Ceramides;Cessation of life;Chemicals;Child;clinical biomarkers;Communities;cytokine;Data;Development;Diabetes Mellitus;diabetes risk;diabetogenic;diagnostic strategy;Disease;DNA Damage;Endocrine;Enzymes;Etiology;Exhibits;Exocytosis;exosome;experimental study;extracellular vesicles;Failure;Functional disorder;Gene Expression;Generations;Genes;genetic manipulation;Goals;Health;Human;human subject;In Vitro;in vivo;in vivo Model;Incubated;Individual;Inflammatory;Insulin-Dependent Diabetes Mellitus;intercellular communication;islet;Islet Cell;Islets of Langerhans Transplantation;Knowledge;Link;Membrane;MicroRNAs;Molecular;mouse model;Multivesicular Body;Mus;nanoparticle;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel diagnostics;novel marker;overexpression;paracrine;Pathway interactions;Physiological;Plasma;Population;Process;Proteins;Research;Risk;Role;Serum;Signal Pathway;Specificity;Sphingomyelinase;Streptavidin;Stress;Surface;targeted biomarker;targeted treatment;Testing;TP53 gene;type I and type II diabetes;uptake;Work

PROJECT_TITLE: Beta cell extracellular vesicles in health and disease

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Human Genome;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE The synthetic lethal interaction of BRCA deficiency with PARPi is being exploited therapeutically in diverse clinical contexts (breast, ovarian, pancreatic, and prostate cancers); however, PARPi resistance has emerged as a vexing clinical problem for the treatment of BRCA1/2-deficient carcinomas. Analyses of PARPi resistance in BRCA1-mutant tumors suggest that loss of genes involved in blocking end resection during HR leads to the partial restoration of HR in the absence of BRCA1 activity. This proposal seeks to evaluate the regulation of these end resecting factors and how they can be exploited to identify and develop novel cancer therapeutics to lessen the burden of disease.

PI_NAMEs: SWIFT, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Attenuated;BARD1 gene;Binding;Blood Cells;BRCA deficient;brca gene;BRCA1 gene;burden of illness;Cancer Biology;cancer cell;Cancer Patient;Carcinoma;Cell Cycle;Cells;Clinical;clinically relevant;combat;Complex;CRISPR screen;Development;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Gene;DNA-PKcs;Equilibrium;Excision;Frequencies;G1 Phase;G2 Phase;Genes;Genome Stability;genome-wide;Genomic DNA;Genomic Instability;genomic profiles;Germ-Line Mutation;homologous recombination;Impairment;in vivo;inhibitor;inhibitor therapy;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;member;Methodology;Modeling;Modification;Molecular;mutant;Mutation;next generation sequencing;Nonhomologous DNA End Joining;novel;nuclease;Ovarian Serous Adenocarcinoma;p53-binding protein 1;Pathway interactions;patient derived xenograft model;Patients;Phase;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;prevent;Primary Neoplasm;Proteins;recruit;refractory cancer;Regulation;repaired;Resected;Resistance;Resistance development;response;restoration;Role;S phase;Sampling;Serine;Serous;Sister Chromatid;synthetic lethal interaction;Therapeutic;therapeutic target;tumor;tumorigenesis;Ubiquitination

PROJECT_TITLE: Evaluating the mechanism by which the DYNLL1-MRE11 complex regulates DNA end resection and genome stability.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Eating Disorders;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE We propose using a wide range of information from 2379 girls in National Growth and Health Study, 1421 children studied in the Section on Growth and Obesity at the Eunice Shriver Kennedy National Institute of Child Health and Human Development (NICHD), and the 16,850 youth in the Growing Up Today Study to identify subgroups of children and adolescents with obesity. We will then examine whether the subtypes are predictive of weight change in adolescence and young adulthood, the development of hypertension before age 35, or have a differential pattern of association with obesity- related genes and whether the subgroups or their relationships vary by sex or race.

PI_NAMEs: HIRSCHHORN, JOEL N;ZIOBROWSKI, HANNAH  (contact)

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: Adolescence;Adolescent;Adolescent and Young Adult;Adult;Age;Appetitive Behavior;bariatric surgery;Behavioral;Binge Eating;biological sex;Body fat;Body mass index;Body Weight Changes;Child;Childhood;Classification;Clinical Trials;Data;Desire for food;Development;Diabetes Mellitus;Disease;disparity reduction;early onset;Eating;Eating Behavior;Eating Disorders;emotional eating;Environmental Risk Factor;Epidemiology;Family;Family history of;Fatty acid glycerol esters;Genes;Genetic;genetic epidemiology;genomic locus;girls;Growth;Health;Heterogeneity;High Density Lipoproteins;high risk;Hunger;Hypertension;loss of control over eating;Measures;Morbid Obesity;National Institute of Child Health and Human Development;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity in children;obesity prevention;Observational Study;Overweight;Pattern;person centered;Phenotype;Physiological;polygenic risk score;Predictive Factor;Prevalence;Prevention;Prospective Studies;psychologic;Race;racial disparity;Research;Risk Factors;sex;sex variable;Subgroup;United States;waist circumference;Weight;Weight Gain;young adult;Youth

PROJECT_TITLE: Phenotyping obesity using behavioral, psychological, physiological, familial, and genetic data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(02)]


NIH_SPENDING_CATS: Arthritis;Bioengineering;Chronic Pain;Clinical Research;Congenital Structural Anomalies;Osteoarthritis;Pain Research;Patient Safety;Pediatric;Rehabilitation

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE  Developmental dysplasia of the hip dramatically increases the risk for early hip osteoarthritis in adolescents and young adults, and is usually treated surgically with a periacetabular osteotomy. The current project will rigorously investigate how periacetabular osteotomy changes hip biomechanics and how those changes are associated with patients’ activity levels and self-reports of function, pain, and quality of life during the first year after surgery. Determining the longitudinal effects of surgery on biomechanics and how they relate to patients’ own perceptions of their recovery will inform new strategies to increase the proportion of patients with DDH who experience better quality of life and delayed osteoarthritis.

PI_NAMEs: HARRIS, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: acetabulum;Adolescent and Young Adult;Affect;Anterior;Arthritis;Biomechanics;Caring;Cartilage;common treatment;Data;Deformity;Degenerative polyarthritis;Deterioration;Development;Disease;Dysplasia;Electronics;expectation;experience;Femur;femur head;Geometry;Goals;Hip Joint;Hip Osteoarthritis;Hip region structure;hip replacement arthroplasty;improved;improved outcome;Intervention;joint biomechanics;Joints;long term recovery;longitudinal analysis;Magnetic Resonance Imaging;Medial;Modeling;Motion;muscle strength;Musculoskeletal;Operative Surgical Procedures;Osteotomy;Outcome;Outcome Measure;Pain;Pain Measurement;Patient Monitoring;Patient Outcomes Assessments;Patient Self-Report;Patient-Focused Outcomes;Patients;peer;Perception;profiles in patients;Quality of life;Questionnaires;Reaction;Recovery;Rehabilitation therapy;Reporting;Risk;Shapes;Structure;success;Surgeon;Symptoms;Testing;Treatment Factor;treatment optimization;wearable sensor technology;Work;young adult

PROJECT_TITLE: Longitudinal Biomechanics and Patient-Reported Outcomes after Periacetabular Osteotomy for Developmental Dysplasia of the Hip

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Immunotherapy;Liver Disease;Lupus

ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: PROJECT NARRATIVE This project is focused on the pathogenesis of systemic lupus erythematosus (SLE), a chronic autoimmune disease of unknown etiology. The proposed research is relevant to public health as SLE affects 0.1% of the US population, mainly women of child-bearing age, with 10% mortality in 5 to 10 years. There is an unmet medical need as current treatments are only partially effective and carry significant side effects. Development of new therapies has been hampered by gaps in our understanding of pathogenesis. Metabolic pathways that control the production of energy in the form of ATP and generate reactive oxygen intermediates (ROI) have emerged as essential regulators of immune responses and contributors to lupus pathogenesis. Comprehensive metabolome studies indicate that SLE profoundly impacts the utilization of glucose through the pentose phosphate pathway (PPP) eliciting changes that mimic deficiency of a rate-limiting enzyme, transaldolase (TAL). In turn, TAL deficiency elicits activation of the mechanistic target of rapamycin (mTOR), which has been recently identified as a key sensor of oxidative stress and driver of inflammation in SLE. The results of the proposed studies will bring new breakthroughs in our understanding of how metabolic pathways control oxidative stress during development of autoimmunity that can be harnessed for safe and effective treatment of SLE.

PI_NAMEs: PERL, ANDRAS  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Adaptive Immune System;Affect;Aldehyde Reductase;Anabolism;Anti-phospholipid Syndrome;Antibody Formation;Antinuclear Antibodies;Antiphospholipid Antibodies;aryldialkylphosphatase;Arylesterase;Autoimmune Diseases;Autoimmunity;autoimmunity checkpoint;Biological Response Modifiers;Carbon;CD3 Antigens;CD8B1 gene;cell type;Cells;Chronic;chronic autoimmune disease;Circulation;Citric Acid Cycle;comorbidity;Complex;congenic;constriction;Development;DNA;effective therapy;Electron Transport;Enzymes;Etiology;Exhibits;Female of child bearing age;FRAP1 gene;Fumarates;gene therapy;Genetic;Glomerulonephritis;Glucose;Glycolysis;glycosylation;Goals;Hepatocyte;Human;IL17 gene;Immune response;Immune system;in vivo;Inflammation;Inflammatory;innovation;inorganic phosphate;Interleukin-4;Knowledge;Liver;Liver diseases;Longitudinal Studies;Lupus;lupus prone mice;Lymphocyte;Mediating;Medical;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;metabolome;Mitochondria;Modeling;mortality;Mus;NADH dehydrogenase (ubiquinone);NADP;Nephritis;novel therapeutics;overexpression;Oxidation-Reduction;Oxidative Stress;Pathogenesis;Pathway interactions;Patients;Pentosephosphate Pathway;pharmacologic;Phospholipids;Plasma;Population;Production;Proteins;Public Health;reactive oxygen intermediate;Regulation;Regulatory T-Lymphocyte;Research;Resolution;Role;sensor;side effect;Sirolimus;stable isotope;Stable Isotope Labeling;stem;systemic autoimmunity;Systemic Lupus Erythematosus;T memory cell;T-Cell Development;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;Transaldolase;Work

PROJECT_TITLE: Metabolic Control of Systemic Autoimmunity

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: COLUMBIA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: PROJECT NARRATIVE The MU PREP, because of the departments and faculty research mentors involved, will have a natural focus on research training in areas that will address major health problems in the U.S. (e.g., cancer, cardiovascular disease, diabetes, and obesity). Of particular interest are health problems that disproportionately affect portions of the U.S. population. This will hopefully lead to greater interest in and research on those health problems at MU, and to a larger number of biomedical researchers working on those problems when our PREP Scholars, and the colleagues they influence, join the biomedical workforce.

PI_NAMEs: DAVID, JOHN D (contact);GARCIA, MICHAEL L;SCHULZ, DAVID J

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Admission activity;Affect;Area;Biological Sciences;biomedical scientist;Cardiovascular Diseases;Communities;Critical Thinking;design;Development;Diabetes Mellitus;Discipline;Doctor of Philosophy;Enrollment;experience;Faculty;faculty mentor;faculty research;Financial Support;forging;Friendships;Future;Goals;graduate school;graduate student;Grant;Health;improved;Institution;Institutionalization;interest;International;Journals;Lead;Malignant Neoplasms;Measures;meetings;Mentors;Missouri;Modeling;novel;Obesity;Paper;peer;peer coaching;Peer Review;Population;Positioning Attribute;Process;programs;Publishing;recruit;Research;Research Personnel;Research Project Grants;Research Training;Resources;responsible research conduct;Rest;retention rate;role model;Science;skills;Students;success;Support System;System;Talents;Teacher Professional Development;Training;Training Programs;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities

PROJECT_TITLE: MU PREP Scholars

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric

PHR: Health Care and Impact (270 characters) This project addresses critical knowledge gap in human genetics by functionally imputing pathogenesis of orofacial cleft associated genes ESRP1, ESRP2 and CTNND1. We will also discover Esrp-regulated genes where epithelial isoforms function in the embryonic periderm that underlies craniofacial morphogenesis.

PI_NAMEs: LIAO, ERIC CHIEN-WEI (contact)

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: Address;Algorithms;Alternative Splicing;Anterior;Benign;Biological Assay;Biology;Birth;Candidate Disease Gene;Cell Line;Cellular Assay;clinically actionable;cohort;Complex;Computing Methodologies;Contracts;craniofacial;craniofacial development;Data;de novo mutation;Defect;Development;Embryo;Epithelium;exome;Face;Genes;Genetic;genetic disorder diagnosis;Genetic study;genetic variant;genome sequencing;Healthcare;Heritability;Human;Human Genetics;In Vitro;in vitro Model;in vivo;Injections;insight;Knock-out;Knowledge;Large-Scale Sequencing;Level of Evidence;Mediating;Mesenchymal;Mesenchyme;Messenger RNA;Modeling;Morphogenesis;Mus;mutant;Mutation;oral cavity epithelium;orofacial cleft;Outcome;overexpression;Palate;paralogous gene;Pathogenesis;Pathogenicity;Patients;Periderm;Phenotype;Protein Isoforms;rare variant;Regulation;Reporter Genes;Research Support;response;Risk;risk variant;Scheme;screening;Signal Transduction;Statistical Methods;Structural Congenital Anomalies;Structure;Surface;Testing;Tissues;Transcript;transcriptome sequencing;transcriptomic profiling;Transfection;Transgenic Organisms;Translating;Variant;Work;Zebrafish

PROJECT_TITLE: Functional analysis of ESRP1/2 and CTNND1 gene variants in orofacial cleft

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Digestive Diseases;Microbiome;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in preterm infants. In this application, we investigate how maternal high fat diet alters susceptibility to NEC, targeting the microbiota and innate immune response, with the goal of identifying novel preventative therapies.

PI_NAMEs: MIRPURI-HATHIRAMANI, JULIE  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Adaptor Signaling Protein;Adoptive Transfer;Affect;Amniotic Fluid;antagonist;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Bacteria;Birth;Cell Physiology;Cell Shape;Cells;Cesarean section;comorbidity;Cost of Illness;Data;Development;Diet;Disease;Effector Cell;Environment;Enzyme-Linked Immunosorbent Assay;experimental study;Exposure to;extreme prematurity;Female of child bearing age;Fostering;Germ-Free;Goals;gut colonization;gut inflammation;healthcare burden;Healthcare Systems;High Fat Diet;Human;Immune;Immune response;Immunity;in utero;In Vitro;in vitro Assay;in vivo;Inflammatory;Injury;Innate Immune Response;intestinal epithelium;Intestines;Knockout Mice;Knowledge;Lactobacillus;Ligands;Lymphoid Cell;Mediating;Mediator;microbiota;Modeling;Morbidity - disease rate;mortality;mother nutrition;Mothers;Mus;MyD88 protein;Natural Immunity;Necrotizing Enterocolitis;Neonatal;neonatal mice;neonate;novel;Obesity;offspring;Overweight;Pathogenesis;Pattern;postnatal;postnatal colonization;Predisposition;premature;Premature Infant;prenatal exposure;prevent;Prevention;Prevention strategy;Preventive therapy;receptor expression;Receptor Signaling;receptor-mediated signaling;residence;Risk;Risk Factors;saturated fat;sensor;Signal Transduction;Sorting;Sterility;Testing;therapeutic target;Time;Toll-like receptors;Woman

PROJECT_TITLE: Mechanisms of maternal high fat diet induced susceptibility to gut inflammation in offspring


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases;Neurosciences;Sexually Transmitted Infections

ORG_CITY: STILLWATER

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: Project Narrative Recurrent herpes simplex virus 1 (HSV-1) infections are significant human health problems that can lead to encephalitis, serious recurrent eye infections, and perhaps an increase in the incidence of Alzheimer's Disease. The ability of HSV-1 to latently infect neurons and then reactivate from latency is required for virus transmission and recurrent disease. Studies in this proposal will characterize the mechanism by which stress and activation of the glucocorticoid receptor disrupts latency and directly stimulates viral gene expression during reactivation from latency.

PI_NAMEs: JONES, CLINTON J (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: acute infection;acute stress;Address;Adrenal Cortex Hormones;Alzheimer's Disease;antagonist;Axon;beta catenin;Binding;Brain Stem;ChIP-seq;Chronic stress;Complex;Dexamethasone;differential expression;disease transmission;Early Promoters;Encephalitis;Eye diseases;Eye Infections;Frequencies;Gene Expression;Genes;Genetic Transcription;Genomics;Glucocorticoid Receptor;Health;Herpes Simplex Infections;Herpesvirus 1;Human;human pathogen;Immune;Incidence;Incubated;Infection;innovation;insight;Knockout Mice;Kruppel-like transcription factors;latency associated transcript;latent infection;Lytic Phase;Maintenance;Mediating;Metabolic;Microarray Analysis;Modeling;Molecular;Mucous Membrane;Mus;mutant;Mutant Strains Mice;neuronal survival;Neurons;Pathway interactions;Physiological;Production;Productivity;promoter;Promoter Regions;protein expression;Proteins;psychologic;Publishing;reactivation from latency;Receptor Activation;Recurrence;Recurrent disease;Regulation;repaired;Research Design;Signal Pathway;Stimulus;Stress;stressor;Structure of trigeminal ganglion;Surface;Testing;transcription factor;Viral;Viral Genes;Viral Regulatory Proteins;viral transmission;Virus;Virus Activation;Virus Shedding;VP 16;Wild Type Mouse

PROJECT_TITLE: Stress-Mediated Regulation of HSV-1 Reactivation from Latency

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE This project aims to develop and establish a novel compressed sensing-based diffusion MRI technique, diffusion dictionary imaging (DDI), to non-invasively and reliably image neuroinflammation in Alzheimer’s disease (AD). By leveraging the established infrastructure of the Knight Alzheimer’s Disease Research center (P50AG05681, P01AG026276, P01AG003991) and Dominantly Inherited Alzheimer Network (DIAN, U19AG032438), we will cost-effectively develop DDI and use it to study the role of neuroinflammation in the sporadic AD and autosomal-dominant AD. The successful development of a quantitative, endogenous DDI biomarker of neuroinflammation will represent a significant technological leap forward and holds significant promise to improve our understanding of the role of neuroinflammation in AD pathogenesis.

PI_NAMEs: WANG, QING  (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Address;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Amyloid deposition;Animal Disease Models;Antibodies;Astrocytes;Autopsy;autosomal dominant Alzheimer's disease;Biological Assay;Biological Markers;Blood;Brain;Cells;Cerebrospinal Fluid;Clinical;clinical application;clinical imaging;Clinical Trials;Cognition;Cognitive;cognitive change;cohort;cost;CSF1R gene;Data;Development;Diagnostic;Dictionary;Diffusion;Diffusion Magnetic Resonance Imaging;Discipline of Nuclear Medicine;Disease;FDA approved;Formalin;Functional disorder;Genetic Heterogeneity;Glial Fibrillary Acidic Protein;Image;imaging biomarker;imaging capabilities;Imaging Device;imaging modality;Imaging Techniques;Immune response;Immunohistochemistry;Immunotherapy;improved;in vivo;indexing;Infiltration;Inflammation;Infrastructure;Inherited;interest;International;Link;Location;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measurement;Measures;Microglia;molecular imaging;Neurofibrillary Tangles;neuroimaging;neuroinflammation;neuron loss;neuropathology;novel;Observational Study;Outcome;Participant;Pathogenesis;Pathologic;Pathology;Patients;Persons;PHF-1;Plasma;Play;Positioning Attribute;Positron-Emission Tomography;Research;response;Role;Sampling;Scanning;Senile Plaques;Severities;Site;spatial relationship;Specificity;Specimen;Stains;Synapses;targeted treatment;tau Proteins;Tauopathies;Techniques;Technology;Testing;therapy development;Tracer;Universities;Walking;Washington;Water

PROJECT_TITLE: Quantitative Endogenous MRI Imaging of Neuroinflammation in AD

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative We are proposing to take advantage of recent developments in PET imaging technology and algorithms to characterize, optimize, and harmonize cancer detection with PET imaging. This will use new artificial intelligence methods and our recent technical developments to provide more accurate measurements and phantoms for translation across multiple systems and imaging sites. This will lead to a roadmap for multi-site and multi-vendor implementation approaches that improve early-stage cancer detection and diagnosis, and thus improved patient outcomes.

PI_NAMEs: KINAHAN, PAUL E. (contact)

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Adoption;Algorithms;Artificial Intelligence;artificial intelligence method;Biological Models;Calibration;Cancer Detection;cancer diagnosis;cancer imaging;cancer recurrence;Cancerous;Cause of Death;Clinical;Data;deep learning model;deep neural network;Detection;detection limit;detection method;Development;Diagnosis;Diagnostic Neoplasm Staging;Discipline of Nuclear Medicine;Disease;Fluorine;fluorodeoxyglucose;Goals;Human;Hybrids;Image;Image Analysis;image reconstruction;imaging system;Imaging technology;improved;industry partner;Infiltration;Institution;intelligent algorithm;Lesion;Link;loss of function;lymph nodes;Malignant Neoplasms;Manuals;Manufacturer;Measurement;Measures;Medical;Metabolic;Methods;Modeling;Modernization;Morbidity - disease rate;novel;open data;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Performance;Physicians;platform-independent;Positron-Emission Tomography;Protocols documentation;Public Health;Publishing;radiologist;reconstruction;Resolution;Screening for cancer;simulation;Site;Staging;System;Time;Tissues;tomography;tool;Translations;tumor;United States;Variant;Vendor;X-Ray Computed Tomography;X-Ray Computed Tomography Scanners

PROJECT_TITLE: Characterizing, optimizing, and harmonizing cancer detection with PET imaging


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Uterine Cancer;Women's Health Research

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project Narrative/Relevance African Americans continue to have poor outcomes after a cancer diagnosis and few African American cohorts exist to support studies of the determinants of cancer prognosis and progression, survival, quality of life and post-treatment outcomes. The proposed continuation of follow-up of this cohort of population-based, African American cancer survivors will provide longer-term outcomes data and biospecimens for a research agenda driven by priorities in the African American community and aimed at understanding and improving cancer outcomes in this population.

PI_NAMEs: BEEBE-DIMMER, JENNIFER L;SCHWARTZ, ANN G. (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: actigraphy;Address;Affect;African American;African American population;Aftercare;Age;Aging;Anxiety;Back;Biological;cancer diagnosis;Cancer Etiology;cancer health disparity;Cancer Prognosis;Cancer Survivor;cancer therapy;Caring;Cessation of life;cohort;Collaborations;Colorectal Cancer;Communities;community engagement;Community Outreach;Community Participation;community partners;comorbidity;Complex;COVID-19 impact;Data;Death Rate;Development;Diagnosis;Disease;disparity gap;Early Diagnosis;early onset;Early treatment;end of life care;Endometrial Carcinoma;Enrollment;Ethnic Population;Event;experience;Family;Financial Hardship;financial toxicity;follow-up;Funding;Geography;Goals;Grant;Health;Health behavior;health equity;improved;Incidence;Institution;Investigation;Link;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medical;Medical History;Medical Records;member;Mental Depression;metropolitan;mortality;Mutation;Neighborhoods;Not Hispanic or Latino;Outcome;outcome disparities;Paper;participant enrollment;participant retention;patient population;Patients;Periodicals;Population;population based;Population Heterogeneity;primary caregiver;psychologic;Publishing;Quality of life;racial population;Recording of previous events;Recurrence;Recurrent disease;Registries;Reporting;Research;Research Priority;Resources;Second Primary Cancers;side effect;sleep health;sociodemographics;Sociology;Source;Surveys;Survivors;survivorship;System;treatment adherence;Treatment outcome;tumor;tumor progression;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;Update;Work

PROJECT_TITLE: Detroit Research on Cancer Survivors (Detroit ROCS)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Parkinson’s disease, dementia with Lewy bodies, and other synucleinopathies are neurodegenerative diseases that affect over 10 million people globally, a number that is only expected to increase as the world’s population ages. Numerous, complex interacting genetic and environmental risk factors are involved in the severity and outcome associated with synucleinopathies, making it unclear why some people develop signs of disease while others do not. I will employ novel approaches to study how multiple genetic factors implicated in synucleinopathies interact in an epistatic manner to trigger and amplify neurodegeneration pathology, which will lead to new mechanistic insights and open therapeutic opportunities.

PI_NAMEs: GOLDMAN, CAMILLE  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Affect;Age;alpha synuclein;Alzheimer's Disease;American;Animal Model;Antibodies;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Autophagocytosis;Biochemistry;Biological Assay;Brain;brain tissue;Cell Line;Cell model;cell type;Cells;Cerebrosides;Cholesterol;Clinical;Coculture Techniques;Complex;Coupled;Coupling;Dementia with Lewy Bodies;Development;Disease;Disease Progression;dopaminergic neuron;dosage;Early Diagnosis;effective therapy;Environmental Risk Factor;Enzymes;flexibility;Functional disorder;Genes;Genetic;genetic risk factor;genetic variant;Genomics;Genotype;Goals;Health;Heterogeneity;Homeostasis;Human;human induced pluripotent stem cells;Image;immunocytochemistry;induced pluripotent stem cell;insight;knock-down;Knock-out;Knowledge;Lead;Link;lipid metabolism;loss of function mutation;Measures;Membrane Potentials;Metabolic;Mitochondria;Modeling;Molecular;motor symptom;Mutation;Nerve Degeneration;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurons;new technology;next generation;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;Parkinson Disease;Pathogenicity;Pathologic;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Persons;Phenotype;Phosphorylation;Population;prevent;Prevention;Proteins;Proteomics;Publishing;Reporter;response;Risk Factors;Severities;single-cell RNA sequencing;synucleinopathy;Techniques;Technology;Testing;Therapeutic;Tissue Model;transcriptomics;United States;Variant;Western Blotting;Work

PROJECT_TITLE: Determining the Interacting Effects of GBA, SNCA, and APOE on a-Synuclein Pathology Severity in Dementia with Lewy Bodies and Parkinson's Disease


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative Epithelial cells are the primary targets of influenza virus infection and we recently demonstrated significant heterogeneity in the levels of replication and antiviral responses of these cells during initial infection and virus spread in vivo. This proposal will uncover the mechanisms of differential replication and the dynamics of virus tropism during spread in vivo. Together this research will aid our understanding of complex virus-host interactions in vivo.

PI_NAMEs: LANGLOIS, RYAN  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Alveolar Cell;Animals;Anti-viral Response;antiviral immunity;Autocrine Communication;Cell Shape;cell type;Cells;Cellular Tropism;Chromatin;Complex;Cytoprotection;Data;design;Environment;Epigenetic Process;Epithelial Cells;Event;experimental study;Flow Cytometry;Fluorescence;fluorophore;Gene Cluster;Genes;Genetic Engineering;Goals;Hemagglutinin;Heterogeneity;Human;Immune response;In Vitro;in vivo;Infection;Influenza;Influenza A virus;influenza infection;influenzavirus;Innate Immune Response;innovation;Integration Host Factors;Interferons;Knowledge;Label;Laboratories;Life Cycle Stages;Lung;Microscopy;Mus;mutant;Natural Immunity;pandemic disease;Paracrine Communication;pathogen;Positioning Attribute;Process;Proteins;receptor;Reporter;Research;Respiratory System;response;Role;Seasons;Secondary to;Sentinel;Series;Shapes;Supporting Cell;System;Techniques;Testing;Therapeutic;Time;tool;Tropism;Vaccines;Viral;viral detection;Viral Genes;Virus;Virus Diseases;virus host interaction;Virus Replication;virus tropism;Work

PROJECT_TITLE: Early Responses to Influenza A Virus Replication In Vivo

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PHR: In this proposed study, we will investigate how the recently identified genetic interaction between DAB1 and  APOE4 increases the risk of developing Alzheimer’s disease. Both APOE4 and DAB1 act on the endocytosis-signaling receptors in the APOE-receptor family and have consequences for Aβ accumulation and microtubule  binding protein τ (MAPT) phosphorylation pointing to potential functional overlap.

PI_NAMEs: HOWELL, BRIAN W. (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: abeta accumulation;Abeta synthesis;Adaptor Signaling Protein;Adult;Age of Onset;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;antagonist;apolipoprotein E-3;apolipoprotein E-4;Apolipoproteins;Area;Binding;Binding Proteins;biobank;Biology;Brain;Cell membrane;Cell Physiology;Cell surface;Cell Surface Receptors;Collaborations;Cytoplasmic Tail;Defect;Development;Disease;disease model;Disease Progression;disorder risk;dosage;Dose;Endocytosis;Endosomes;Family;Functional disorder;Generations;Genes;Genetic;Genetic Epistasis;Genetic Risk;Genetic Transcription;genome wide association study;genome-wide;Genotype;Goals;Heterozygote;Histologic;Human;Individual;Late Onset Alzheimer Disease;LDL-Receptor Related Protein 1;Lipids;Microtubules;Modeling;mouse model;Mus;Neurons;Pathology;Pathway interactions;Phenotype;Phosphorylation;Population;Positioning Attribute;Price;Probability;receptor;Receptor Inhibition;receptor internalization;Receptor Signaling;reelin receptor;Reelin Signaling Pathway;Risk;Risk Factors;Role;Senile Plaques;Signal Transduction;tau Proteins;Testing;Tyrosine Phosphorylation;Variant

PROJECT_TITLE: Resolving the genetic interaction between DAB1 and APOE4 in Alzheimer's.

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE This research project should help us better understand how general anesthetics work, in particular, how they remove consciousness in the anesthetized patient. The knowledge gained should help develop novel approaches to determine the presence or absence of consciousness during general anesthesia and in patients with disorders of consciousness. Using anesthetic drugs as investigational tools, the project should also help understand how nerve cells in the brain collaborate to create human and animal consciousness.

PI_NAMEs: HUDETZ, ANTHONY GEORGE (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Affect;Afferent Neurons;Anatomy;Anesthesia procedures;Anesthetics;Animals;association cortex;Basic Science;Behavioral;Behavioral Assay;Biological Assay;Biological Models;Brain;Cerebral cortex;Chronic;Code;Collaborations;Complex;Conscious;Consciousness Disorders;desflurane;Development;Dexmedetomidine;Dose;electrical microstimulation;Electrophysiology (science);Event;experience;flexibility;General Anesthesia;General anesthetic drugs;Goals;Human;Hybrids;Implant;improved;in vivo;indexing;information processing;Investigation;Ketamine;Knowledge;Lead;Maps;Mental disability;mental state;Methods;Microelectrodes;microstimulation;Modification;Monitor;network models;Neurobiology;neuronal circuitry;neuronal patterning;Neurons;Neurophysiology - biologic function;novel;novel strategies;Parietal;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Photic Stimulation;physically handicapped;Play;Population;Process;Propofol;Psyche structure;Rattus;Recurrence;Reproducibility;Research Project Grants;Rodent;Running;Sensory;sensory cortex;sensory integration;sensory stimulus;spatiotemporal;Specificity;Stereotyping;Stimulus;System;Task Performances;Testing;Time;tool;transmission process;treadmill;Unconscious State;virtual;virtual environment;virtual reality;virtual reality environment;Visual;Visual Cortex;visual stimulus;Work

PROJECT_TITLE: General Anesthetics and Cerebral Cortical Sensory Integration

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative Dysregulation of mTORC1 signaling is often found in various types of health problems. Our study is designed to test the hypothesis that BASP1 functions as a key activator of mTORC1 acting downstream of NPC1 and upstream of GATOR1 in vitro and in vivo. This will provide new molecular connections between cellular lipid metabolism, anabolic processes, and many human health problems such as obesity, diabetes, lysosomal storage diseases, neurodegenerative diseases, and cancer development.

PI_NAMEs: INOKI, KEN  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Ablation;Acids;Adipose tissue;Adult;Amino Acids;Autophagocytosis;Binding;Binding Proteins;Brain;Brain region;Catabolic Process;cell growth;cell growth regulation;Cell membrane;Cells;Cholesterol;cholesterol-binding protein;Complex;Cues;Data;design;Development;Diabetes Mellitus;diet-induced obesity;Disease;Dissociation;Eating;Event;experimental study;FRAP1 gene;Genetic;Growth;Growth Factor;GTPase-Activating Proteins;Guanine;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;Health;Heterozygote;High Fat Diet;Human;In Vitro;in vitro activity;in vivo;inhibitor;insulin sensitivity;Knockout Mice;Link;lipid metabolism;Lipids;Lipolysis;Lysosomal Storage Diseases;Lysosomes;male;Malignant Neoplasms;Membrane;Membrane Lipids;Membrane Microdomains;Metabolic;Metabolic Diseases;methyl-beta-cyclodextrin;Modeling;Molecular;Monomeric GTP-Binding Proteins;mouse model;Mus;Mutation;Neurodegenerative Disorders;Niemann-Pick Diseases;NPC1 gene;nucleotide metabolism;Obesity;organ growth;Pathologic;Pathway interactions;Phenotype;Phosphatidylinositol 4,5-Diphosphate;Physiological;Play;Process;protein complex;Protein Kinase;Proteins;recruit;Regulation;Resistance;Role;Signal Transduction;Signaling Protein;Sirolimus;Testing;Therapeutic;Thinness;Tissues;Weight Gain

PROJECT_TITLE: Lysosomal cholesterol-dependent anabolic regulation

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The proposed research will study the specific causal impact of three modifiable family processes—parental monitoring, parental warmth, and family conflict—on substance abuse and delinquency during adolescence in a diverse, population-based cohort. This knowledge will improve the accuracy of etiological models and guide the refinement and personalization of (preventive) interventions to reduce the burden of these problems on adolescents, their families, and society.

PI_NAMEs: PELHAM III, WILLIAM ELLERBE (contact)

PROGRAM_OFFICER_NAME: VIDAL, SARAH

PROJECT_TERMS: 10 year old;Acute;Adolescence;Adolescent;adolescent substance abuse;adolescent substance use;Age;Attention;Brain;Child Rearing;Chronic;Cognitive;cohort;conduct problem;Conflict (Psychology);Cross-Sectional Studies;Data;Data Collection;design;Development;Dizygotic Twins;Dose;effective intervention;Environment;Ethnic Origin;Etiology;Exposure to;Family;Family Process;Genes;Genetic;improved;Incidence;individual variation;innovation;Intervention;intervention effect;Knowledge;Longitudinal Studies;Measurement;Meta-Analysis;Modeling;Monozygotic twins;offspring;Outcome;parental monitoring;Parents;Population;population based;precision medicine;Predisposition;prevent;Prevention program;Preventive;Problem behavior;Process;programs;prospective;protective factors;Psychopathology;Publishing;Race;recruit;Research;Resources;response;Risk;Risk Factors;Role;Sampling;Science;Severities;sex;Siblings;Site;Societies;Socioeconomic Status;Structural Models;Substance abuse problem;substance use;Time;treatment program;Twin Multiple Birth;Youth

PROJECT_TITLE: Family processes underlying adolescent substance use and conduct problems: disentangling correlation and causation

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Genetics;Human Genome;Regenerative Medicine;Wound Healing and Care

ORG_CITY: MADISON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Vocal fold (VF) scarring is one of the greatest challenges in the field of laryngology, with devastating effects on communication and quality of life. VF scarring is the outcome of dynamic, reciprocal processes in multiple cell types that are not well understood. The goal of this proposal is to understand the subpopulations, location, and proximity of cells that contribute to VF injury response and repair in vivo using a bioinformatics approach.

PI_NAMEs: WENDT, KRISTY DERHEA (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Adult;Affect;Bioinformatics;biomarker identification;Cell Communication;Cell Lineage;cell type;Cells;Chromosome Mapping;Cicatrix;Communication;Complex;Control Animal;Data;Development;differential expression;Disease;Dysphonia;Engineering;engineering design;Environment;Epithelial Cells;Epithelium;experimental study;Extracellular Matrix;Fibroblasts;Fibrosis;FVB/N Mouse;Gene Expression;Gene Expression Profiling;Genes;Goals;healing;Health;Health Care Costs;Heterogeneity;Immune;in vivo;Individual;Inflammatory;Inflammatory Response;Injury;injury and repair;innovation;innovative technologies;Laboratories;Lamina Propria;Larynx;Libraries;Location;Macrophage;Maps;Mentors;Mesenchyme;Modeling;Molecular;mouse model;Movement;Mucous Membrane;Multiple Wounds;Mus;Myofibroblast;Natural regeneration;novel marker;Occupational;Operative Surgical Procedures;Organ;Outcome;Patients;Phase;Phenotype;Pliability;Population;Population Heterogeneity;Positioning Attribute;Process;Quality of life;re-epithelialization;regenerative approach;repaired;Research;Research Training;response;response to injury;Role;single-cell RNA sequencing;Spatial Distribution;Suspensions;Testing;Therapeutic;therapeutic target;Time;Tissue Engineering;Tissue Harvesting;tissue regeneration;tissue repair;Tissues;transcriptome;transcriptome sequencing;Translations;Unemployment;vocal cord;Voice;Work;wound;wound healing

PROJECT_TITLE: Transcriptome dynamics during vocal fold injury and repair


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Lung;Networking and Information Technology R&D (NITRD);Pulmonary Hypertension;Rare Diseases

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: PROJECT NARRATIVE Pulmonary arterial hypertension (PAH) is involved in 200,000 hospitalizations per year in the United States with has high mortality rates due to impaired right ventricular (RV) function. The prognosis is very poor with five-year survival <50%, and there are no available therapies to prevent right heart failure. The goal of this research is to investigate the tissue mechanisms by which remodeling of the collagen extracellular matrix in PAH alters RV myocardium stiffness initially to compensate and how in the progression of the disease this stiffening reverse leading to RV dilation in a well-established rat model.

PI_NAMEs: VALDEZ-JASSO, DANIELA  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Animal Model;Automobile Driving;Biological;biomechanical test;Biomechanics;Blood Vessels;Cardiac;Chronic;Clinical Research;Collagen;Compensation;Core-Binding Factor;Data;Death Rate;design;Differential Equation;Dilatation - action;Disease;Disease Progression;electric impedance;experimental study;Extracellular Matrix;Fibroblasts;Fibrosis;Geometry;Goals;hemodynamics;Hospitalization;Hypertrophy;Impairment;In Vitro;in vitro Model;in vivo;Lung;Lung Diseases;mathematical model;Measurement;Measures;mechanical load;mechanical properties;Mechanics;Mediating;Modeling;Morbidity - disease rate;mortality;multi-scale modeling;Muscle Cells;Myocardial;Myocardium;network models;new therapeutic target;novel;Outcome;Pathogenesis;Pathway interactions;patient prognosis;Patients;Phase;Phenotype;Physiological;Physiology;preservation;prevent;Profibrotic signal;Prognosis;Property;Property Rights;pulmonary arterial hypertension;pulmonary arterial pressure;Rattus;recruit;Research;response;Right Ventricular Dysfunction;right ventricular failure;Right Ventricular Function;right ventricular remodeling;Right ventricular strain;Sampling;Signal Pathway;Signal Transduction;Stimulus;Stress;Structure;Systems Biology;Testing;Time;Tissues;United States;Vascular Diseases;Ventricular

PROJECT_TITLE: Multiscale Modeling of Right Ventricular Fibrotic Remodeling in Pulmonary Arterial Hypertension

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


ADMINISTERING_IC: LM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences;Prevention

ORG_CITY: HOBOKEN

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY

ORG_STATE: NJ

PHR: Project Narrative Big data can form the basis for more precise, personalized, interventions for ICU patients, but it is challenging for clinicians to integrate a large number of complex signals. Our work will allow data to guide treatment by making machine learning more accurate and providing better ways of combining insights from many patients (each of whose data may be incomplete). These will aid in understanding consciousness in neurological and neonatal ICUs.

PI_NAMEs: KLEINBERG, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Ablation;Address;Admission activity;Adult;Age;Algorithms;Altered Level of Consciousness;automated assessment;Behavior assessment;Big Data;Black Box;Brain;Brain Injuries;Cardiovascular system;Caring;causal model;Classification;Clinical;clinical decision support;clinical practice;Clinical Trials;Cognitive;Complex;Conscious;Consensus;Consumption;Critical Illness;Data;Disease;Early Intervention;effective intervention;Electroencephalography;Environment;Evaluation;functional outcomes;Goals;Health;Hospitals;Human;Impairment;improved;Individual;individual variation;insight;Intensive Care Units;Intervention;Knowledge;large datasets;Lead;Learning;learning strategy;Link;Machine Learning;machine learning algorithm;Measurement;Measures;Medical;Methods;Modeling;Neonatal;Neonatal Intensive Care Units;neonatal patient;neonate;Neurologic;Neurological status;open source;Outcome;Output;Patient Care;Patients;Pattern;Performance;Physiological;Population;premature;pressure;Prevalence;prevent;Privacy;privacy preservation;Prognosis;Proxy;Quality of life;Research;Research Personnel;Resolution;respiratory;response;Risk Factors;Series;Signal Transduction;simulation;stroke patient;symptom treatment;System;Testing;Time;tool;Unconscious State;Withdrawal;Withdrawing Care;Work

PROJECT_TITLE: BIGDATA: Causal Inference in Large-Scale Time Series


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Narrative The timing of sleep depends upon the coordinated action of two different systems in the body, the endogenous circadian system that imposes a 24 hour rhythm and the homeostatic system that ensures an organism gets enough sleep. This proposal will determine how, on a cellular level, the circadian and homeostatic systems interact to control the timing of sleep. It will allow us to understand why misaligned sleep cycles, which are common in modern society (e.g. due to shiftwork or jetlag), are associated with severe health consequences, including neurological disorders.

PI_NAMEs: SEHGAL, AMITA  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Address;Arousal;Automobile Driving;behavior influence;Binding;Biological Assay;Biological Clocks;Black race;Brain;Calcium;Cells;circadian;Circadian desynchrony;circadian pacemaker;circadian regulation;Circadian Rhythms;Communication;Cues;Data;deprivation;Dorsal;Drosophila genus;Ensure;experimental study;Feedback;Ganglia;Goals;Health;Homeostasis;Hour;insight;Jet Lag Syndrome;Life Style;Light;Link;Maps;Measures;Mediating;Medical;Modeling;Modernization;Motor;Motor Activity;Nervous System Disorder;neural;Neurons;novel;Organism;Output;Pathway interactions;Periodicity;Play;Predisposition;Regulation;response;Response to stimulus physiology;Role;Shapes;shift work;Signal Transduction;Sleep;Sleep Deprivation;Sleep disturbances;sleep regulation;Societies;Stroke;System;Testing;Time;transcriptome sequencing;transmission process;Wakefulness;Work

PROJECT_TITLE: Interaction between circadian and sleep circuits

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: This study examines two novel ways to improve functioning and recovery among Veterans with serious mental illness (SMI). It will assess the effectiveness of established psychosocial interventions based on cognitive- behavioral therapy (CBT) and stand-alone social skills training (SST) when delivered by Peer Specialists— Veterans with SMI trained to use their own experience and recovery to help other Veterans with SMI. The project will compare outcomes of Veterans with SMI receiving one of three treatments: Cognitive Behavioral Social Skills Training-Peer (CBSST-Peer), stand-alone Social Skills Training-Peer (SST-Peer), or a peer-led, manualized goal setting group. This work is responsive to national calls for Veterans with SMI to receive support that is evidence-based, improves functioning (not just symptoms), and is tailored to individual needs. If successful, CBSST or SST could be adopted by the 1100 Peer Specialists working in VA, greatly increasing the delivery of evidence-based services to these Veterans.

PI_NAMEs: CHINMAN, MATTHEW  (contact);GRANHOLM, ERIC L

PROJECT_TERMS: Address;Administrator;Adopted;Adoption;Advocate;arm;Attitude;Audiotape;Behavioral;Caring;Categories;Clinical;Code;Cognitive;cognitive skill;cognitive testing;Cognitive Therapy;Collaborations;Communication;cost;Data;Education;Educational Curriculum;Educational process of instructing;effective therapy;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;effectiveness trial;evidence base;experience;Focus Groups;follow-up;Foundations;functional improvement;Future;future implementation;Goals;Healthcare;Healthcare Systems;Homelessness;hospital bed;Hour;Hybrids;Impairment;implementation barriers;implementation determinants;implementation evaluation;implementation facilitators;improved;improved outcome;Independent Living;Individual;innovation;Intercept;Intervention;Interview;Knowledge;Letters;Licensing;Manuals;Measures;Medical center;Mental Health;Methods;novel;Outcome;Outcome Study;Participant;Patient-Focused Outcomes;Patients;peer;peer support;Perception;Persons;Pharmaceutical Preparations;post intervention;primary outcome;programs;psychosocial;psychosocial rehabilitation;Quality of life;Randomized;Recovery;recruit;Rehabilitation therapy;Research;response;Role;Sampling;Schizophrenia;Services;severe mental illness;Severities;Site;skills;skills training;social communication;Social Functioning;social skills;Socialization;Specialist;standard care;standardize measure;Strategic Planning;Structure;Supervision;Surveys;Symptoms;Techniques;Testing;Text;theories;Thinking;Time;Training;treatment arm;treatment effect;Update;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Evaluating the Use of Peer Specialists to Deliver Cognitive Behavioral Social Skills Training

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Emergency Care;HIV/AIDS;Health Services;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_NAME: RHODE ISLAND HOSPITAL

PHR: PROJECT NARRATIVE Although both HIV and injury are immense global problems, there is a paucity of research on their intersection in high HIV burden African regions; where those most likely to seek treatments for emergent injuries, young adult males, are also a difficult to access group which require novel and effective HIV engagement approaches to contribute to ending the epidemic. This research will generate robust data on the intersection of HIV and injury to address knowledge gaps in HIV care among those seeking emergency treatments in Kenya, and investigate the implementation of an innovative emergency department-based HIV self-testing program.

PI_NAMEs: ALUISIO, ADAM RUSSELL (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Accident and Emergency department;acute care;Address;Adoption;Affect;Africa South of the Sahara;African;Age;care delivery;career;career development;Caring;Characteristics;Counseling;Country;Data;design;Effectiveness;effectiveness/implementation design;Emergency Care;Emergency Department patient;Emergency research;Emergency Situation;Emergency treatment;empowerment;Enrollment;Epidemic;epidemic response;Epidemiology;experience;Foundations;Future;Goals;Growth;Guidelines;Health;Health care facility;Health Promotion;Healthcare;high risk;high risk population;HIV;HIV risk;Human immunodeficiency virus test;implementation research;implementation science;implementation trial;improved;indexing;Individual;injured;Injury;innovation;Intervention;Kenya;Knowledge;Lead;low and middle-income countries;male;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;Morbidity - disease rate;mortality;neglect;novel;novel strategies;Nurses;patient population;Patients;Persons;Policies;poor health outcome;Population;Productivity;programs;Prospective cohort;Provider;Public Health;Qualitative Methods;Qualitative Research;Recommendation;Research;Research Methodology;Research Personnel;research study;Scientist;self testing;Self-Examination;service engagement;Services;Site;social;standard care;System;Testing;testing uptake;Training;transmission process;uptake;Vulnerable Populations;Work;World Health Organization;young adult;young man

PROJECT_TITLE: HIV in Injury: eValuation of Self-Testing in African Emergency Care for the Injured (HIV AECI)

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Immunotherapy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE This project will investigate the potential of the commonly prescribed antibiotic, Azithromycin, as an immunomodulatory agent to speed recovery and reduce injury-exacerbated Alzheimer’s disease neuropathological changes following an acquired brain injury. Hypothesis-based drug repurposing of azithromycin will provide a novel therapeutic agent for use in Alzheimer’s disease, with a reduced time frame for the drug development.

PI_NAMEs: BACHSTETTER, ADAM D (contact);GENSEL, JOHN C

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Acceleration;Acute;Age;age related;aging brain;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;American;amyloid pathology;Antibiotics;APP-PS1;Area;arm;Astrocytes;Azithromycin;Behavioral;Behavioral Assay;Biological Products;blood-brain barrier crossing;Brain;Brain Injuries;Clinical Research;Closed head injuries;Cognitive;Cognitive deficits;cost;Data;Dementia;disorder risk;Dose;drug development;drug discovery;drug efficacy;drug repurposing;Drug Targeting;Drug usage;Environmental Risk Factor;Evaluation;Evaluation Research;experience;Exploratory/Developmental Grant;Failure;falls;FDA approved;Gliosis;Goals;Histopathology;human old age (65+);immune modulating agents;immunomodulatory therapies;immunoregulation;Immunosuppressive Agents;improved;Incidence;Infection;infection risk;Inflammation;Inflammatory;Injury;Kentucky;Knock-in Mouse;medical attention;Microglia;mild traumatic brain injury;Modeling;mouse model;Nervous System Trauma;neuroinflammation;neuropathology;neuroprotection;novel therapeutics;Odds Ratio;older adult;Outcome;Pathology;Patient-Focused Outcomes;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase;Phenotype;Population;Populations at Risk;Positioning Attribute;pre-clinical;Pre-Clinical Model;Predisposition;prevent;primary endpoint;Property;Prophylactic treatment;Radial;Recovery;Research;research and development;Resolution;response;Risk;Safety;Speed;Spinal cord injury;Synapses;tau Proteins;TBI treatment;Testing;Therapeutic;Therapeutic Agents;therapeutic development;therapeutic evaluation;Time;TNF gene;Traumatic Brain Injury;treatment duration;Universities;water maze;Wild Type Mouse;Work

PROJECT_TITLE: Drug repurposing for Alzheimer’s disease-related inflammation caused by a TBI


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Rare Diseases;Women's Health Research

ORG_CITY: LAWRENCE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE Fragile X-associated tremor/ataxia syndrome (FXTAS) is a severe, progressive disorder of aging caused by “premutation” expansions (55-200 CGG repeats) of the FMR1 gene on the X chromosome. Knowledge of key phenotypes and their neural substrates is severely lacking for females with FXTAS, limiting progress in clarifying mechanistic pathways and advancing more targeted therapeutics. The proposed R21 will identify quantitative motor and cognitive phenotypes associated with FXTAS in women, determine their neurophysiological correlates, and test associations with select gene and molecular markers implicated in FXTAS degeneration in females.

PI_NAMEs: MOSCONI, MATTHEW W (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Address;Age;aging brain;aging related disease;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-Protein Precursor;Apolipoprotein E;Autopsy;Behavior;behavior test;Behavioral;Brain;brain behavior;Case Study;Cells;cellular pathology;Cerebellum;Cessation of life;CGG repeat;Clinical;Clinical Research;Cognitive;cognitive change;Corpus striatum structure;Data;Dementia;Development;Dimensions;Disease Pathway;Disease Progression;Executive Dysfunction;Female;FMR1 gene;FMR1 Premutation;Functional Magnetic Resonance Imaging;FXTAS;Genes;Genetic;genetic association;Genetic Markers;Goals;healthy aging;Hippocampus;imaging study;Impaired cognition;Impairment;infancy;Interruption;Knowledge;Length;Literature;Lobule;male;Memory;Memory impairment;Memory Loss;memory process;men;Methods;Middle frontal gyrus structure;mitochondrial dysfunction;Molecular;molecular marker;molecular pathology;Molecular Profiling;Molecular Target;Motor;motor behavior;motor disorder;motor impairment;Mutation;mutation carrier;Nerve Degeneration;neural;Neurodegenerative Disorders;neurophysiology;oculomotor;Outcome;Oxidative Stress;Parahippocampal Gyrus;Parietal Lobe;Pathology;Pathway interactions;Patients;Pattern;Penetrance;Phenotype;premature;Process;Quality of life;Retrieval;Risk;Saccades;Severity of illness;sex;specific biomarkers;Symptoms;targeted treatment;Testing;trait;verbal;visual information;Woman;women versus men;Women's study;Work;X Chromosome

PROJECT_TITLE: Neurodegenerative mechanisms of motor, executive, and memory decline in females with Fragile X-associated tremor/ataxia syndrome (FXTAS)

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: MH

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE The ability to form and maintain social relationships is core to our existence and is impaired in individuals with severe mental disorders, such as autism, depression, and others. We aim to investigate the neural computations that could support the behavioral trajectories of social relationships under real-life group conditions.

PI_NAMEs: YARTSEV, MICHAEL MOSHE (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Address;Animals;Anterior;Area;autism spectrum disorder;Behavior;behavior measurement;Behavioral;Biological Models;Brain;Calcium;Chiroptera;Chronic stress;cingulate cortex;Clinical;Communication;Complex;Data;design;Development;Dimensions;Disabled Persons;Disease;Electrophysiology (science);Ethology;Evolution;experimental study;flexibility;Flying body movement;Fruit;Functional disorder;Future;Human;Image;Impairment;improved;Individual;individual variation;insight;Intervention;Life;Light;Mammals;Measurement;Mediating;Mediation;member;Mental Depression;Mental disorders;Methods;millisecond;Monitor;Nature;Nervous System;neural;neural circuit;neural network;neurobiological mechanism;Neurobiology;neuromechanism;Neurons;neurophysiology;novel;novel strategies;optogenetics;Participant;Patients;Personality Traits;Population;prevent;Research;Resolution;response;Role;severe mental illness;Shapes;Signal Transduction;social;social attachment;Social Behavior;social communication;Social Conditions;Social Distance;social group;social influence;Social Interaction;Social Network;social relationships;social structure;Techniques;Technology;Testing;Time;tool;Translating;wireless

PROJECT_TITLE: From Social Networks to Neural Networks: Investigating the Neural Basis of Real-Life Social Relationships


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Although antiretroviral therapy (ART) is now widely available, people with HIV continue to have shorter life expectancy compared to the general population. We previously found that gut barrier dysfunction predicted mortality in persons with ART-suppressed HIV and a history of AIDS. Cytomegalovirus (CMV), a common coinfection in HIV, disrupts the gut barrier, and a recent clinical trial showed that a drug active against CMV reduced harmful immune activation in HIV-infected participants. In this project, we will study the role of CMV in gut barrier dysfunction and immune activation. We predict that treatment for CMV infection will help restore gut barrier function and improve outcomes for HIV-infected individuals on ART.

PI_NAMEs: HUNT, PETER W;SHACKLETT, BARBARA L. (contact)

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS clinical trial group;Ancillary Study;Antigen Presentation;antigen-specific T cells;antiretroviral therapy;base;Biological Markers;CD8-Positive T-Lymphocytes;Cells;Chronic;Clinical Trials;co-infection;cohort;Colorectal;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Vaccines;Defect;Dendritic Cells;Disease;DNA;Epitopes;exhaustion;Failure;Functional disorder;Funding;gastrointestinal;gastrointestinal epithelium;Gastrointestinal tract structure;General Population;Gut Mucosa;HIV;HIV Infections;Homing;immune activation;Immune System Diseases;imprint;improved;improved outcome;in vivo;Individual;Infection;intestinal barrier;Life Expectancy;Macaca mulatta;Measures;Mediating;microbial;Modeling;Modified Vaccinia Virus Ankara;mortality;Mucous Membrane;Parents;Participant;Pathogenesis;Pathway interactions;peripheral blood;Persons;Pharmaceutical Preparations;Plasma;Prediction of Response to Therapy;Recording of previous events;response;Role;senescence;Series;Site;Specificity;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Tight Junctions;Tissues;trafficking;Tretinoin;United States National Institutes of Health;Vaccination;vaccination strategy;vaccine strategy;Vaccine Therapy;Vaccines;vector vaccine

PROJECT_TITLE: Cytomegalovirus (CMV), the gut barrier and immune dysfunction in HIV


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Lymphatic Research;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: We propose to establish how meningeal lymphatic vessels mediate neuroimmune communication in the developing brain, and how they can be harnessed to enhance early T-cell education in a mouse model of pediatric brain tumor. We will use unbiased approaches, based on new mouse genetic models and cutting-edge molecular and imaging techniques that we have established, to manipulate meningeal lymphatic growth, assess their role in the transport of brain-derived molecules and in the traffic of antigen- presenting cells, and investigate mechanisms leading to T cell reponses in the collecting lymph nodes. Our results will enhance knowledge in this understudied area and may lead to novel translational approaches to combat pediatric brain tumors by increasing neuroimmune communication via meningeal lymphatics, and by boosting tumor antigen transport, T cell priming and anti-tumor effector function.

PI_NAMEs: EICHMANN, ANNE CHRISTINE;IWASAKI, AKIKO ;THOMAS, JEAN-LEON  (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: 3-Dimensional;Ablation;adaptive immune response;adaptive immunity;Adult;Adult Glioblastoma;Affect;Alzheimer's Disease;American;angiogenesis;Antigen-Presenting Cells;Antigens;Area;Behavior;Binding;Birth;Brain;Brain Neoplasms;brain tissue;Cancerous;cell motility;Cells;Central Nervous System;Central Nervous System Diseases;Central Nervous System Neoplasms;Cerebrospinal Fluid;Child;Childhood;Childhood Brain Neoplasm;combat;Combined Modality Therapy;Common Neoplasm;Communication;Cues;Data;Development;Drainage procedure;draining lymph node;Education;Environment;Flow Cytometry;Fluorescence Microscopy;Genetic;Genetic Models;Glioblastoma;Goals;Growth;Head;Health system;Image;Imaging Techniques;Immune;Immune checkpoint inhibitor;Immune response;Immune system;Immunity;Immunology;improved;Injections;Intercellular Fluid;Ischemic Stroke;Knock-out;Knowledge;Label;Life;Light;Liquid Chromatography;lymph nodes;Lymphatic;lymphatic drainage;Lymphatic Endothelial Cells;Lymphatic System;lymphatic vasculature;lymphatic vessel;macromolecule;Maintenance;Mass Chromatography;Mass Spectrum Analysis;Measures;Mediating;Mediator;Medulloblastoma;Meningeal lymphatic system;Meninges;Modeling;Molecular;Molecular Analysis;Monitor;Mothers;mouse genetics;mouse model;multidisciplinary;Multiple Sclerosis;Mus;Neonatal;neuro-oncology;Neuroimmune;Neurology;Neurons;Neuropilin-2;Neuropilins;Newborn Infant;novel;novel strategies;novel therapeutics;Parkinson Disease;Passive Immunity;pathogen;Pathology;Pediatric Neoplasm;Pediatric Oncology;Peripheral;pharmacologic;Play;postnatal;Procedures;Proteins;Proteomics;Protocols documentation;receptor;Receptor Protein-Tyrosine Kinases;Reporter;Resources;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Sinus;spine bone structure;synergism;T-Cell Activation;T-cell receptor repertoire;T-Lymphocyte;therapeutic target;Time;Tissues;Tracer;translational approach;transmission process;Traumatic Brain Injury;tumor;Tumor Antigens;tumor growth;Uterus;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factor Receptor-3;Work

PROJECT_TITLE: Role of meningeal lymphatic vasculature in neuroimmune communication development