NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Natural Products

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative This project utilizes synthetic chemistry, microbiology, genetics, and proteomic methods to develop novel compounds to combat bacteria. This research will develop narrow-spectrum and antivirulence tool compounds as potential therapeutic agents that either inhibit growth or biofilm processes within pathogenic bacteria. The compounds are derived from natural product scaffolds isolated from regions rich in chemical diversity and bioactivity, which will undoubtedly shed light on the chemical underpinnings of these complex microbial communities.

PI_NAMEs: WUEST, WILLIAM M (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Affect;analog;Area;Bacteria;Biochemical;Biological;Biological Assay;chemical property;chemical synthesis;Chemical Warfare;Chemicals;combat;Complex;design;Development;Disease;Endowment;Environment;Evaluation;fungus;Genetic;Goals;Growth;Health;Human;improved;inhibitor;interest;Invaded;Lead;medical implant;Methods;Microbial Biofilms;microbial community;Microbiology;Molecular Genetics;natural product derivative;natural product inspired;Natural Products;Nature;novel;novel strategies;novel therapeutics;Organic Synthesis;pathogenic bacteria;physical property;Plants;polymicrobial biofilm;prevent;Process;Property;Proteins;Proteomics;Reporting;Research;Resistance development;scaffold;Source;Synthesis Chemistry;Techniques;Testing;Therapeutic;Therapeutic Agents;therapeutic target;tool;transcriptomics;Translations;Virulence

PROJECT_TITLE: Natural Product-Inspired Approaches Toward The Development Of Antivirulence And Species-Specific Inhibitors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Dissemination and Implementation Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Prevention;Rehabilitation;Suicide;Suicide Prevention

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: LYSSN.IO, INC.

ORG_STATE: WA

PI_NAMEs: ATKINS, DAVID CHARLES (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Active Listening;Administrator;Age;Artificial Intelligence;artificial intelligence algorithm;behavioral health;burnout;care providers;Caring;Cause of Death;Client;Clinical;cloud platform;cloud software;Cognitive Therapy;Collaborations;commercialization;Communities;Computer software;cost;Counseling;COVID-19;Crisis Intervention;dashboard;Digit structure;Dimensions;Empathy;Evaluation;Failure;Feedback;Floods;Frequencies;Guidelines;Health Insurance Portability and Accountability Act;Human;implementation evaluation;implementation outcomes;improved;Institution;Intervention;Interview;Investments;Language;Machine Learning;Maintenance;Methods;Monitor;mortality risk;motivational enhancement therapy;National Institute of Mental Health;Outcome;Performance;Persons;Phase;Pilot Projects;prevention service;Professional counselor;quality assurance;Randomized;Reporting;Research;Risk;Risk Assessment;Secure;Services;services as usual;skill acquisition;skills;Small Business Innovation Research Grant;suicidal morbidity;suicidal risk;Suicide;Suicide prevention;Supervision;System;Technology;Text;Time;tool;Training;United States;Universities;usability;Validation;Voice;web platform

PROJECT_TITLE: Voice-based AI to scale evaluation of crisis counseling in 988 rollout


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative Inositol 1,4,5-trisphosphate receptors (IP3Rs) are calcium channels that are ubiquitously expressed in all eukaryotic cells and play important roles in regulation of a broad range of physiological processes in humans. Dysfunctions in IP3Rs are associated to numerous human diseases, including neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Huntington’s diseases, stroke, and cancer, and therefore these channels are important drug targets. The proposed studies aim to understand the detailed structure and fundamental mechanisms governing IP3R channel function and to elucidate how they are perturbed in disease states that will aid in search for novel therapies to treat disorders related with abnormal cell calcium homeostasis.

PI_NAMEs: SERYSHEVA, IRINA I (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Abnormal Cell;Address;Affect;Alzheimer's Disease;Architecture;Binding;Biochemical;Biophysics;Calcium;Calcium Channel;Calcium Signaling;Cell Physiology;Coupled;Cryoelectron Microscopy;deep neural network;Development;Disease;Drug Targeting;Electrophysiology (science);Endoplasmic Reticulum;Ensure;Eukaryotic Cell;extracellular;Family;Functional disorder;Homeostasis;Human;human disease;Huntington Disease;Image;inorganic phosphate;Inositol;insight;interdisciplinary approach;Ions;ITPR1 gene;Knowledge;Ligand Binding;Ligands;Malignant Neoplasms;Mediating;Membrane;Methods;Molecular;Molecular Conformation;Motion;Mutagenesis;Neurodegenerative Disorders;Neurons;novel therapeutics;Parkinson Disease;Pathologic;Physiological Processes;Play;Process;programs;Property;Protein Isoforms;Proteins;receptor;Regulation;Research;Resolution;Role;Shapes;Signal Pathway;Signal Transduction;Stimulus;Stroke;Structure;Work

PROJECT_TITLE: Mechanisms of inositol trisphosphate receptor-mediated calcium signaling

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Autophagy plays a role in normal physiological processes including fetal development and innate immunity, and its dysfunction has been implicated in a wide range of human diseases including cancer, some types of neurodegeneration, bacterial and viral infections, gastrointestinal disorders, diabetes and heart disease. It may be possible to modulate autophagy for therapeutic purposes, turning it on and off at precise times, and in specific tissues, to prevent or ameliorate the onset of diseases or their symptoms. To use autophagy in this manner, however, will require a complete understanding of its mechanism and regulation.

PI_NAMEs: KLIONSKY, DANIEL J. (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Affect;Autophagocytosis;Autophagosome;Bacterial Infections;Biochemical;Biogenesis;Cell Death;Cellular biology;Complex;Cytoplasm;Cytoprotection;Developmental Process;Diabetes Mellitus;Disease;Elements;Eukaryota;experimental study;Fetal Development;Functional disorder;Gastrointestinal Diseases;Goals;Heart Diseases;Homeostasis;Human;human disease;innovation;Knowledge;Learning;Link;Lysosomes;Malignant Neoplasms;Mammals;Membrane;Molecular;Molecular Genetics;Mutation;Natural Immunity;Nerve Degeneration;Onset of illness;Organelles;Pathway interactions;Physiological Processes;prevent;Process;Proteins;Regulation;Research;Signal Transduction;Structure;Symptoms;System;Therapeutic;Therapeutic Intervention;Tissues;Vacuole;Vesicle;Virus Diseases;Yeasts

PROJECT_TITLE: The mechanism and regulation of autophagy

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LARAMIE

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: Project Narrative: Nuclear morphology is often deregulated in cancer cells, many cancers are diagnosed and staged based on graded increases in nuclear size, and little is known about the causes or effects of nuclear morphology changes in cancer. We will identify regulators of nuclear size and shape, elucidate mechanisms of nuclear morphology regulation, and use this information to investigate how nuclear morphology affects embryonic development, cell differentiation, and carcinogenesis, shedding light on novel approaches and targets for the diagnosis and treatment of cancer. Aberrant nuclear morphology in cancer might be necessary for cell homeostasis and viability, so therapeutic manipulation of nuclear morphology could provide a means to selectively target and kill only affected cells.

PI_NAMEs: LEVY, DANIEL LEON (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Actins;Address;Affect;Area;Biochemical;Biological;Caenorhabditis elegans;cancer cell;cancer diagnosis;cancer therapy;carcinogenesis;Cell Cycle;Cell Differentiation process;Cells;Collaborations;Complex;Cytoplasm;Cytoskeletal Modeling;Development;Diagnosis;Diagnostic Neoplasm Staging;Disease;egg;Embryo;Embryonic Development;Encapsulated;experimental study;Future;Gene Expression;Genetic Transcription;Giant Cells;Goals;Homeostasis;human induced pluripotent stem cells;Image;in vivo;induced pluripotent stem cell;insight;Knowledge;Lamins;Light;Malignant Neoplasms;Microfabrication;Microfluidics;Microscopy;Morphology;multiple omics;novel;novel strategies;Nuclear;Organelles;Osmosis;Paper;Ploidies;Positioning Attribute;Productivity;proteotoxicity;Protocols documentation;Publishing;reconstitution;Regulation;Research;Resolution;RNA interference screen;Sea Urchins;Shapes;Stress;Subcutaneous Tissue;Techniques;Therapeutic;tumor progression;Vision;Work;Xenopus

PROJECT_TITLE: Mechanisms of nuclear morphology regulation

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: Project Narrative Comparative genomics and genetic engineering in model organisms are powerful tools that can be used to understand the biology underlying human traits, diversity and disease. We will study how essential proteins can evolve given the constraints imposed by the often multifaceted functions they perform, including for example, the important drug-target Na+,K+-ATPase, which has repeatedly evolved insensitivity to steroid inhibitors across diverse animals. Our work will yield insights into how new proteins associated with neurological and physiological disorders in humans, like Na+,K+-ATPase, can evolve new functions.

PI_NAMEs: ANDOLFATTO, PETER  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Amino Acid Substitution;Amino Acids;Animals;ATP phosphohydrolase;Behavior;Biology;Chromosome Mapping;comparative genomics;Cre lox recombination system;CRISPR/Cas technology;Data;Dependence;Development;Disease;Drosophila genus;Drosophila melanogaster Proteins;Drug Targeting;Eating;Engineering;Evolution;Exhibits;experience;Fertility;fitness;Gene Expression Profiling;Genes;Genetic;genetic analysis;genetic architecture;Genetic Determinism;Genetic Drift;Genetic Engineering;Genetic Epistasis;Genetic Variation;Genome;genome editing;Genome engineering;genome wide association study;Genomics;Glycosides;Homeostasis;Human;Human Biology;human disease;In Vitro;in vivo;Individual;inhibitor;innovation;Insecta;insight;K ATPase;Learning;Link;Maps;model organism;Molecular;Molecular Genetics;Mutation;Natural Selections;Nature;Neurologic;novel;Outcome;pathogenic bacteria;pathogenic virus;permissiveness;Phenotype;Physiological;Plants;Population;Population Genetics;Process;Property;protein function;Proteins;Quantitative Trait Loci;Recurrence;Resistance;Role;Shapes;Site;Steroids;System;Technology;Time;tool;Toxic effect;Toxin;trait;Variant;Vertebrates;whole genome;Work

PROJECT_TITLE: Effects of genetic background on adaptive evolution


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition;Obesity;Sleep Research

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Public Health Statement: Obesity and Alzheimer’s disease (AD) devastate millions of Americans and place a tremendous burden on our healthcare system. Necessities of modern society put immense pressure on human physiology by forcing incongruity between endogenous circadian rhythms and environmental cycles, which worsens a range of health issues including obesity associated maladies and AD. This project aims to identify the neuronal circuits and the molecular players that control circadian rhythms and therefore identify therapeutic targets to circumvent these pathologies.

PI_NAMEs: GULER, ALI  (contact)

PROGRAM_OFFICER_NAME: SESMA, MICHAEL A

PROJECT_TERMS: Acceleration;adverse outcome;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;American;Astronomy;Behavior;behavioral response;Biological Process;circadian;Circadian desynchrony;circadian pacemaker;Circadian Rhythms;Cues;Diet;Dopamine Receptor;Dopaminergic Cell;dopaminergic neuron;Event;Exercise;Food;Food Access;food consumption;food restriction;Genetic Transcription;Goals;Health;Healthcare Systems;high risk;Hour;Human;Hypothalamic structure;insight;Laboratories;Light;Lighting;Metabolic;Metabolic Diseases;Metabolic dysfunction;Midbrain structure;Modernization;Molecular;mouse model;neural circuit;Neurodegenerative Disorders;neuronal circuitry;Neurons;novel;Obesity;parent project;Pathology;Pathway interactions;Periodicity;Persons;Physiological;Physiology;pressure;Prevalence;Public Health;Recurrence;reduce symptoms;response;Rewards;Signal Transduction;Social Interaction;Societies;Stress;suprachiasmatic nucleus;Target Populations;therapeutic target;Time;Weight Gain;Work

PROJECT_TITLE: Interplay between circadian and reward pathways in homeostatic response and pathology


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Many types of cancer cell utilize a special outer layer – called a glycocalyx – to help stick to and invade soft tissues such as the brain, lung, and breast. This proposal seeks to 1) use DNA-based nanosensors to elucidate how the glycocalyx helps cancer cells become invasive, and 2) develop screening methods for early detection of glycocalyx-coated cancer cells in the bloodstream. The outcome of this research may offer new design principles for targeted cancer therapy, as well as technologies for early detection of cancer.

PI_NAMEs: BLANCHARD, AARON  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: 3-Dimensional;Adaptor Signaling Protein;Adhesions;anti-cancer research;Biochemical;Biological Assay;Biophysical Process;Biophysics;Blood;Blood Circulation;Blood specimen;Brain;Breast;cancer cell;Cancer Diagnostics;cancer type;career;Cell Adhesion;Cell Adhesion Molecules;Cell surface;Cells;Clinical;Coagulation Process;Cytoskeleton;design;Detection;detection method;Development;Diagnostic;DNA;Doctor of Philosophy;Early Diagnosis;Elements;experience;experimental study;Fibrinogen;Fluorescence Microscopy;Fluorescence Polarization;fluorophore;Glioblastoma;Glycocalyx;Glycoproteins;Human;Image;Image Analysis;Immobilization;improved;Individual;Integrins;Invaded;Letters;Literature;Lung;Maps;Measures;mechanical device;mechanical properties;Mechanics;Mediating;Methods;Modeling;Molecular;Molecular Conformation;Motor;nano;nanosensors;Nature;Neoplasm Circulating Cells;Neoplasm Metastasis;Observation in research;Outcomes Research;overexpression;Phase;Platelet Activation;Postdoctoral Fellow;Process;Property;recruit;Recurrence;Research;Role;Sampling;screening;Screening for cancer;Series;simulation;skills;soft tissue;Specificity;Structure;targeted cancer therapy;Techniques;Technology;Testing;therapeutic target;Thick;Tissues;tool;Vinculin;Work

PROJECT_TITLE: The mechanical role of the glycocalyx in cancer cell adhesion


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Immunotherapy;Nanotechnology;Women's Health Research

ORG_CITY: AMES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE This impactful proposal will enable multiplexed detection of both PD-L1 and CD8 immunomarkers simultaneously in vivo and monitor response to immunotherapies through a cutting-edge multimodal nanoprobe, immunoactive gold nanoparticles (IGNs). IGNs, labeled with antibodies, Raman reporters, and radiotracers, seamlessly integrates depth-resolved whole-body imaging of positron emission tomography (PET) with high spatiotemporal resolution and multiplexing of surface-enhanced Raman spectroscopy (SERS) allowing to track the dynamic changes in both immunomarkers during treatment directly in vivo. IGNs is a generalizable platform and our strategy can be mapped onto multiple disease models where PD-L1 and CD8 markers play a key role transforming the therapeutic outcome for responders, and accelerate clinical decisions for nonresponders.

PI_NAMEs: BARDHAN, RIZIA  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Acceleration;Address;Aftercare;Alternative Therapies;alternative treatment;anti-PD-L1;anti-PD-L1 therapy;Antibodies;Antigens;Autoimmunity;Beta Cell;Binding;Biological Assay;Biological Markers;biomedical imaging;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Treatment;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Clinical;clinical translation;Clinical Trials;clinically relevant;Detection;diagnostic tool;Disease;disease model;Dose;Early Diagnosis;Heterogeneity;Histopathology;Human;humanized mouse;Image;imaging biomarker;Immunocompetent;ImmunoPET;immunoregulation;Immunosuppression;Immunotherapy;improved;in vivo;in vivo imaging;Infection;Infiltration;inhibitor;innovation;Insulin-Dependent Diabetes Mellitus;interest;Internal Breast Prosthesis;intraperitoneal;islet;Label;Ligands;Light;longitudinal positron emission tomography;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Measures;Methods;Monitor;Monoclonal Antibodies;mouse model;multidisciplinary;Multimodal Imaging;multimodality;multiplex detection;Mus;nanoGold;nanoparticle;nanoprobe;noninvasive diagnosis;novel;Optics;orthotopic breast cancer;Outcome;patient screening;patient subsets;Patients;PD-L1 blockade;Peripheral Blood Mononuclear Cell;Play;Positron-Emission Tomography;pre-clinical;predicting response;programmed cell death ligand 1;programmed cell death protein 1;Radiation exposure;Radiochemistry;Radioimmunoconjugate;Radioisotopes;Radiolabeled;radiotracer;Raman Spectrum Analysis;receptor;Regimen;Reporter;Resolution;response;Retrieval;Role;screening;Signal Transduction;spatiotemporal;Specificity;spectroscopic imaging;Spectrum Analysis;Surface;T-Cell Activation;Techniques;Therapeutic;therapy outcome;tissue fixing;translational study;Treatment Protocols;treatment response;tumor;tumor-immune system interactions;Up-Regulation;Wait Time;whole body imaging

PROJECT_TITLE: Developing Multimodal Multiplexed ImmunoPET-Raman Probes to Guide Immunotherapies

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Complementary and Integrative Health;Digestive Diseases;Genetics;Human Genome;Liver Disease;Physical Activity;Rehabilitation

ORG_DEPT: SURGERY

PHR: Project Narrative This project will determine the mechanisms by which preoperative exercise therapy suppresses surgical stress-induced colorectal liver metastasis. These studies will provide a more comprehensive understanding of the role of preoperative exercise therapy in ameliorating surgical stress-induced pro-tumorigenic inflammatory responses and sustaining an anti-tumor immune microenvironment. The anticipated mechanisms will be valuable to identifying potential pharmaceutical targets in hepatic CRC metastasis and provide the intellectual framework for devising new exercise therapies that are mechanism-based and effective in improving surgical outcomes of cancer patients.

PI_NAMEs: TSUNG, ALLAN  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Abdomen;Adoptive Transfer;Anti-Inflammatory Agents;Attenuated;Biological;Cancer Patient;Cells;Clinical;colon cancer patients;Colorectal;Colorectal Cancer;colorectal cancer metastasis;Curative Surgery;Cytometry;Data;Disease;Disease-Free Survival;Environment;Epigenetic Process;Excision;Exercise;Exercise Therapy;extracellular;Foundations;Gene Expression Profile;Genetic;Goals;Growth;Hepatic;Immune;Immune response;Immunity;Immunologics;immunoregulation;improved;improved outcome;infancy;Infection;Infiltration;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;Injury;innate immune function;Ischemia;Knowledge;Kupffer Cells;Link;Liver;Macrophage;Malignant Neoplasms;Mediating;Mediator;Metabolic;Metastasis Induction;metastatic colorectal;Metastatic Neoplasm to the Liver;Micrometastasis;Modality;Modeling;Molecular;mortality;mouse model;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;neutrophil;novel;Operative Surgical Procedures;Outcome;participant enrollment;Pathway interactions;Patients;Perioperative;pharmacologic;Pharmacologic Substance;Phenotype;Play;predicting response;prevent;Process;Proliferating;Quantitative Evaluations;randomized, clinical trials;Recurrence;Recurrent disease;Recurrent tumor;Relapse;Reperfusion Therapy;Resected;response;Risk;Role;single cell technology;single-cell RNA sequencing;Stains;Stress;surgery outcome;Surgical Models;targeted treatment;Technology;Testing;Time;Training;transcriptomics;Treatment Failure;tumor;tumor growth;tumor microenvironment;tumor progression;tumor-immune system interactions;tumorigenic

PROJECT_TITLE: Surgery triggered immune response and liver metastases

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Aging;HIV/AIDS

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: OVERALL: CALIFORNIA NATIONAL PRIMATE RESEARCH CENTER PROJECT NARRATIVE The California National Primate Research Center is an established national resource that has as a primary mission to improve human health and quality of life through support of exceptional nonhuman primate research programs that advance our knowledge of the causes, preventions, treatments, and cures of debilitating diseases. This mission is pursued through robust and well-developed on-site research programs, facilities, and expertise that are significantly augmented by collaborative programs that serve the greater biomedical research community. We are particularly committed to understanding health and diseases across the entire lifespan.

PI_NAMEs: ATKINSON, SIMON J. (contact)

PROGRAM_OFFICER_NAME: BUHRING, BETTINA D

PROJECT_TERMS: Address;Age;Aging;Alzheimer's Disease;Anatomy;animal care;Animal Experimentation;Animals;Appointment;Area;base;Behavior;behavioral health;biobehavior;Biological Assay;Biomedical Research;California;career;Caring;Clinical Pathology;Collaborations;college;Communicable Diseases;Communities;Core Facility;COVID-19;Dedications;Development;Disease;Education and Outreach;Elderly;Ensure;fighting;Flow Cytometry;Fostering;Funding;Genetic;Goals;Grant;Growth;Health;Health Services;high standard;Human;human disease;improved;industry partner;Information Technology;Infrastructure;Inhalation Exposure;Institution;Knowledge;Laboratories;Lead;life span;Medical;Medicine;Mentors;Mission;Modeling;Multimodal Imaging;National Institute on Aging;Neurosciences;next generation;nonhuman primate;operation;outreach;population health;Prevention;Primates;programs;psychologic;Quality of life;recruit;Regenerative Medicine;Reproductive Sciences;Research;Research Design;Research Personnel;Research Priority;Research Support;Resources;responsible research conduct;Role;Schools;Science;Scientist;Services;Site;tool;Training;translational scientist;United States National Institutes of Health;Universities;Veterinarians;Vision;ZIKA;Zika Virus


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Pediatric;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: There is a critical shortfall in the number and diversity of undergraduate students that enter the STEM workforce relevant to the NIDDK mission. To address this challenge, we recruit and engage undergraduates from backgrounds underrepresented in the NIH workforce in an “Aspirnaut STEM Pipeline for Diversity and Wellness” that encompasses research experiences, professional skills development, and wellness training.

PI_NAMEs: HUDSON, BILLY GERALD (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Academic Medical Centers;Address;American Indians;Area;Biology;Cancer Education Grant Program;career;college;Communication;Data;Development;disadvantaged background;Disease;Diverse Workforce;economic disparity;Education;Educational Status;ethnic minority population;Ethnic Population;experience;Face;Family;Funding;geographic disparity;Geography;Graduate Degree;guided inquiry;high school;holistic approach;Individual;innovation;Internships;Kidney;matriculation;Medical;Mission;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Native Americans;next generation;Occupations;Outcome;Participant;Pharmacology;programs;racial minority population;racial population;recruit;Research;Schools;Science;Science, Technology, Engineering and Mathematics;Scientist;skill acquisition;skills;STEM career;STEM field;Students;success;summer research;Training;Training Programs;undergraduate student;United States;United States National Institutes of Health;Veterinary Schools;Wellness Program

PROJECT_TITLE: Undergraduate Discovery Science Experience in Renal Biology and Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative This research program aims to develop and apply linear and multidimensional spectroscopy in combination with residue-selective labeling of proteins with frequency-resolved vibrational probes to advance understanding of functional roles of conformational ensembles and protein dynamics in important biological processes, ranging from signaling to drug metabolism and tumor suppression. Understanding how conformational heterogeneity and dynamics contribute in these selected systems will not only elucidate fundamental aspects of biology, but also generate testable models for how they contribute to biological processes that underlie human health generally.

PI_NAMEs: THIELGES, MEGAN CORRINE (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TITLE: Functional Protein Conformations and Dynamics via Transparent Window 1D & 2D Infrared Spectroscopy


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Digestive Diseases;Microbiome;Pain Research

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: Irritable Bowel Syndrome(IBS) is a chronic disorder effecting 7-16% of the US population and with $1 billion of direct health care costs annually. This project will define fundamental aspects of host- microbe interactions in the small intestine during IBS to develop novel therapeutics approaches.

PI_NAMEs: SPENCER, SEAN PAUL (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Abdominal Pain;Antigens;Award;Bacteria;bacterial community;bile acid metabolism;Bile Acids;Biology;capsule;Carbohydrates;career;career development;Characteristics;Chronic Disease;Clinical Data;Clinical Research;clinical training;colon microbiota;Communities;Complement 2;Data;Deglutition;Development;Development Plans;Devices;Diagnosis;dietary;Dietary intake;Disease;Distal;dysbiosis;Ecology;Ecosystem;effective therapy;Ensure;Environment;experience;Feces;Frequencies;Gastroenterology;Gastrointestinal Diseases;Gastrointestinal tract structure;Germ-Free;Gnotobiotic;Goals;gut microbiota;Health Care Costs;host microbiota;host-microbe interactions;Human;Human Microbiome;human microbiota;Immune;Immune system;Immunity;Immunologic Stimulation;Immunology;improved;In Vitro;Inflammatory;Institution;Intestines;Irritable Bowel Syndrome;knowledge base;Leadership;Libraries;Maps;Medicine;Mentors;Mentorship;metabolomics;Metagenomics;Methods;Microbe;microbial;microbiome research;microbiota;microbiota composition;Molecular Genetics;mouse model;Mus;novel;novel strategies;novel therapeutic intervention;Outcome;Patients;Phenotype;Phylogenetic Analysis;Physicians;Physiology;Population;Preclinical Testing;programs;Property;repository;Research;Research Personnel;Research Training;Resolution;Resources;Ribosomal RNA;Role;sample collection;Sampling;Sampling Studies;Science;Scientist;Severities;Site;skill acquisition;skills;Small Intestines;stool sample;success;Symptoms;Technology;Testing;Therapeutic;tool;Training;Universities;whole genome;Work

PROJECT_TITLE: Defining Small Intestinal Microbial Landscapes To Improve Therapeutics For Gastrointestinal Disease

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Efficient intracellular delivery of nucleic acids, proteins and drugs is a critical step in diverse scenarios ranging from cell-based therapy and gene editing to regenerative medicine and fundamental biology. This proposal will develop a novel NanoEngineered Surface Technology Microfluidics to quantitatively study cell membrane disruption and recovery response and create a next generation intracellular drug delivery system with precise dose control, low toxicity, low cost, high efficiency and high throughput.

PI_NAMEs: DING, XIAOYUN  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Biological;biological research;Biological Response Modifier Therapy;Biology;Biomedical Research;cell behavior;Cell membrane;Cell Therapy;cell type;Cells;Colorado;Communities;Complex;cost;Development;Devices;Disparate;Dose;Drug Delivery Systems;Engineering;experimental study;frontier;Genes;Glean;Goals;Industrialization;Injury;insight;Interdisciplinary Study;Medical;Medicine;Membrane;Methods;microfluidic technology;Microfluidics;Microinjections;Molecular;nanoengineering;new technology;next generation;novel;nucleic acid delivery;Permeability;Pharmaceutical Preparations;Physics;Play;Property;Proteins;Recovery;Regenerative Medicine;repaired;Research;response;Role;submicron;Surface;Techniques;Technology;Toxic effect;Universities

PROJECT_TITLE: Cell membrane disruption and recovery for intracellular delivery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: SAN FRANCISCO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Viruses called bacteriophages kill bacteria through fascinating and diverse mechanisms making them timely therapeutic candidates to combat antibiotic resistant pathogens. Here, I study a phage that potently kills Pseudomonas aeruginosa using bizarre and previously unobserved mechanisms to hide from anti-phage immune enzymes like CRISPR-Cas. This multidisciplinary project will unveil the molecular details of this remarkable immune evasion mechanism to guide identification and development of better phage therapeutics.

PI_NAMEs: MOZUMDAR, DEEPTO  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Affinity;Antibiotic Resistance;Antibiotics;antimicrobial;arms race;Bacteria;bacterial resistance;Bacteriophages;Biochemical;Biogenesis;Biological;Biology;Biophysics;cell envelope;Cell Nucleus;Cell Separation;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Complex;Cryo-electron tomography;Density Gradient Centrifugation;Development;DNA;DNA Packaging;drug resistant pathogen;Encapsulated;Engineering;Ensure;Environment;Enzymes;Excision;Exclusion;experimental study;Family;Family member;fascinate;fighting;Fluorescence Microscopy;Fostering;Genetic;genetic approach;Genetic Materials;Genome;Genomic DNA;Goals;Growth;Head;Immune;Immune Evasion;Immune system;In Situ;Infection;innovation;insight;Liquid substance;Location;macromolecular assembly;Mass Spectrum Analysis;Messenger RNA;Microbiology;Microscopy;Modeling;Molecular;Molecular Biology;Molecular Sieve Chromatography;multidisciplinary;novel strategies;nuclease;Organelles;pathogen;pathogenic bacteria;Plaque Assay;post-doctoral training;Production;programs;Proteins;Pseudomonas aeruginosa;Public Health;recruit;Research;research facility;Resolution;Role;Sampling;structural biology;Structure;success;Sucrose;Supervision;Technology;temporal measurement;Testing;Therapeutic;therapeutic candidate;Training;translational goal;Transmission Electron Microscopy;Virus;Visualization;Work

PROJECT_TITLE: Elucidation of the mechanisms of jumbophage genome protection during infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Ataxia Telangiectasia;Brain Disorders;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pediatric;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_DEPT: GENETICS

ORG_STATE: GA

PHR: Narrative Summary: Failure to efficiently repair DNA damage plays a role in the progression of many different diseases, including neurodegenerative diseases such as Ataxia Telangiectasia. Our goal is to understand how R-loops, three stranded structures comprised of an RNA strand complimented with a DNA strand and another free-floating DNA strand, are regulated in the DNA damage response pathway through an ATM-METTL3-m6A axis. Such studies may provide novel targets for therapeutic treatments for Ataxia Telangiectasia.

PI_NAMEs: WESTOVER, KATHERINE R. (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Affect;Age;ATAC-seq;Ataxia Telangiectasia;ataxia telangiectasia mutated protein;Ataxia Telangiectasia Patients;ATM deficient;ATM Gene Mutation;Autopsy;autosome;brain tissue;Cell Nucleus;Cell Physiology;cell type;Cells;Central Nervous System;Chromatin;Clinical;clinically relevant;Cytoplasm;Data;data integration;Defect;Deposition;Disease;DNA;DNA Damage;DNA Repair;DNA Structure;Double Strand Break Repair;early childhood;Eye;Failure;Gene Expression;Genome;genome editing;genome-wide;Goals;Hybrids;Immune;Impairment;improved;induced pluripotent stem cell;loss of function;Malignant Neoplasms;Maps;Mediating;mental development;Messenger RNA;Methyltransferase;mimetics;Modeling;Modification;Molecular;Monitor;Motor;motor neuron development;Motor Neurons;mRNA Translation;Mus;Mutation;mutation correction;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;Neuronal Differentiation;Neurons;new therapeutic target;Onset of illness;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Persons;Phosphorylation;Phosphotransferases;Play;Post-Transcriptional Regulation;Protein-Serine-Threonine Kinases;Proteins;Purkinje Cells;Regulation;repaired;response;RNA;RNA immunoprecipitation sequencing;RNA Splicing;Role;Signal Pathway;Signal Transduction;Structure;Telangiectasis;Testing;Threonine;Transcriptional Regulation;transcriptome sequencing;Translating;trend

PROJECT_TITLE: Genome-wide dysregulation of R-loops in Ataxia Telangiectasia neurological pathogenesis


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Digestive Diseases;Food Allergies;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: PEDIATRICS

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Food allergy is a serious public health concern affecting 8% of children in the US. The goal of this proposal is to further investigate racial/ethnic differences and disparities in food allergy outcomes between Black, White, and Latinx children in FORWARD, a prospective longitudinal cohort, and identify factors that contribute to differences in developing and outgrowing food allergies, managing food allergies during middle childhood and adolescence, and variations in phenotypes and endotypes.

PI_NAMEs: GUPTA, RUCHI S (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Address;Adolescence;Affect;Age;Allergens;Anaphylaxis;Asthma;behavioral outcome;Black race;Caregivers;Child;Child Care;Childhood;Clinical;Clinical assessments;Clinical Data;clinical development;cohort;Collection;Communities;comorbidity;cost;Data;Data Reporting;data resource;design;Development;Diagnosis;Dimensions;Disease Management;Disparity;Eating Behavior;Eczema;Emergency department visit;Enrollment;Ensure;Environment;Epinephrine;ethnic difference;Ethnic Origin;experience;Family;fecal microbiome;follow-up;Food;Food Hypersensitivity;Geography;Goals;Guidelines;Health Knowledge Attitudes Practice;Health Policy;Heterogeneity;Hispanic;Home;Immune Tolerance;Impairment;infancy;Knowledge;Knowledge Management;Latinx;Latinx population;Life;Linguistics;Literature;Longitudinal cohort;Methodology;Methods;Mexican;Mexican Americans;middle childhood;National Institute of Allergy and Infectious Disease;Not Hispanic or Latino;novel;nutrition;Outcome;Parents;Participant;Patient Outcomes Assessments;Patient Self-Report;Patients;peer;Pharmaceutical Preparations;Phenotype;Practice Management;precision medicine;Prevalence;Prevention;Privatization;prospective;Prospective Studies;psychosocial;psychosocial outcome;Public Health;Puerto Rican;Quality of life;Race;racial difference;racial disparity;Reaction;recruit;Reporting;Research;sample collection;Sample Size;Sampling;Self Management;Serum;Severities;Site;skin microbiome;sociodemographic factors;socioeconomics;Subgroup;Surveys;Symptoms;Testing;treatment optimization;United States;Variant

PROJECT_TITLE: Food Allergy Management and Outcomes Related to Racial/Ethnic Differences from Infancy through Adolescence: The FORWARD Study

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative The proposed studies will provide a comprehensive, mechanistic understanding of how peripheral sensory nerves regulate progenitor cell fate, aberrant wound healing and heterotopic ossification (HO). Facilitated by the use of conditional deletion animals and near-clinical therapies, these results will provide novel insights into key regulatory elements of the HO program, while serving to identify new targets for therapeutic intervention of this currently untreatable process.

PI_NAMEs: JAMES, AARON W;LEVI, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: afferent nerve;Agonist;Amputation;Analgesics;Animal Model;Animals;Area;AVIL gene;Axon;Biological Availability;Blood Vessels;bone;bone fracture repair;brief intervention;Cells;Clinical;Clinical Research;Communication;comparative efficacy;Couples;Data;Data Set;Defect;Dendrites;Denervation;Disease;Disease Progression;Distal;Elements;Event;Excision;experimental study;follow-up;Follow-Up Studies;Gelatin;Growth;Heterotopic Ossification;Human;Hydrogels;in vivo;insight;Lesion;limb injury;Link;Mesenchymal;Mesenchymal Stem Cells;Modeling;Molecular;Mus;Nerve;Nerve Growth Factors;nerve supply;Neurons;neurotransmission;neurotrophic factor;neutralizing antibody;neutralizing monoclonal antibodies;new therapeutic target;non-opioid analgesic;novel;Operative Surgical Procedures;Oral;osteoarthritis pain;osteochondral tissue;Osteogenesis;Pain;Pathologic;Pathway interactions;Patients;Pericytes;Peripheral;Peripheral Nerves;Phase;Phenotype;Phosphotransferases;Pilot Projects;Postoperative Pain;precursor cell;prevent;Prevention;Process;programs;receptor;Recurrence;Regimen;Regulation;Regulatory Element;repaired;response;Role;Sensory;Series;Signal Transduction;Site;Skeleton;small molecule;small molecule inhibitor;Smooth Muscle Myocytes;Source;Specificity;stem cell differentiation;stem cell fate;Stimulus;Surface;targeted treatment;Testing;TGFB1 gene;Therapeutic Intervention;therapeutic target;Tissue Differentiation;Tissues;Trauma;Tropomyosin;Vascular Smooth Muscle;wound healing

PROJECT_TITLE: Impact of peripheral nerves on mesenchymal cell fate in extremity trauma

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Services;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE  Adolescence is typically when initial signs of psychosis develop, and social impairment is often one the first of these signs to emerge; however, little is known about specific factors that contribute to social impairment. The proposed study seeks to use cutting-edge ambulatory technology to examine physiologic threat dysregulation (TD) and its relation to social impairment and psychotic-like experiences in adolescence, and whether these relationships are partially mediated by aberrant cognitive and affective responses to threat. These results should develop ambulatory technology as a novel “early warning system” for assessing psychosis, thus contributing to reduced disability and early mortality associated with psychosis and other psychopathology.

PI_NAMEs: HORTON, LESLIE E (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Acute;Adolescence;Adolescent;Affect;Affective;Age;age difference;age group;aged;Ambulatory Monitoring;Arousal;Autonomic nervous system;Award;biological adaptation to stress;Biological Process;Cardiac;Cardiovascular system;Cellular Phone;Chronic;Clinical;Clinical assessments;clinical high risk for psychosis;clinically relevant;Cognitive;comparison control;Congenital neurologic anomalies;Development;Diagnostic;disability;Disease susceptibility;Early identification;Early treatment;Ecological momentary assessment;Emotional;Exhibits;experience;follow up assessment;Fright;Goals;high risk;Home;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Impairment;improved;In Vitro;in vivo;Individual;innovation;Intervention;Investigation;Laboratories;Life;Link;Literature;longitudinal design;Measures;Mediating;Methods;Modeling;mortality;multimodality;National Institute of Mental Health;negative affect;novel;Outcome;Participant;Pathway interactions;Patient Self-Report;Persons;Physiological;Prevention strategy;Procedures;Psychopathology;Psychophysiology;Psychoses;psychosis risk;Psychotic Disorders;psychotic symptoms;psychotic-like experiences;Puberty;Recovery;recruit;Research;research clinical testing;Research Domain Criteria;response;Rest;Risk;Role;Sampling;Schizophrenia;sex;Sex Differences;social;Social Functioning;Social Processes;social relationships;Stress;stressor;System;Technology;Testing;Theoretical model;Time;Visit;wearable device;Youth

PROJECT_TITLE: Ambulatory Monitoring of Threat Dysregulation in Adolescents at Risk for Psychosis

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Infectious Diseases;Rare Diseases

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE We will use falsifiable forecasting, mathematical modeling and statistical methods to help world-health partner organizations identify when and where Trachoma (a blinding disease) will be eliminated as a public health problem worldwide. This includes modeling approaches for resolving persistent infection in hot spot areas, and improving surveillance to detect any resurgence of disease.

PI_NAMEs: LIETMAN, THOMAS M (contact);PORCO, TRAVIS CHRISTIAN

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TITLE: Forecasting Trachoma Control

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Human Genome;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: PROJECT NARRATIVE Vocal learners, like humans and songbirds, require experience with adults of their species while they are young to learn and ultimately imitate their vocalizations, but how this early experience is encoded and interacts with circuits for vocal production is not well understood. The essential song learning and motor production nucleus, HVC, contains non-overlapping cell types that project to different regions. This research will elucidate if there are cell-type-specific genetic and synaptic changes in HVC that underly sensory learning and how learning from social experience interacts with motor circuits in HVC.

PI_NAMEs: OROZCO, CARLOS GIOVANNI (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: acronyms;Adult;Affect;Area;ATAC-seq;Auditory;auditory nuclei;Basal Ganglia;Birds;Brain;Cell Nucleus;cell type;Cells;Chemosensitization;Chromatin;Chromatin Structure;critical period;Data;Development;differential expression;early experience;Electrophysiology (science);Epigenetic Process;epigenomics;Exhibits;experience;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;hatching;Hearing;Hour;Human;Immediate-Early Genes;Learning;Life;Maps;Measures;Memory;Modeling;Motor;Motor Cortex;Motor output;Motor Pathways;multiple omics;Names;neural circuit;Neurons;Neurophysiology - biologic function;optogenetics;Pathway interactions;Phase;Physiologic pulse;postsynaptic;postsynaptic neurons;Presynaptic Terminals;Probability;Production;Prosencephalon;Research;RNA;Role;Sensory;Shapes;single nucleus RNA-sequencing;social;social learning;Songbirds;Synapses;Synaptic Receptors;Testing;Tissue-Specific Gene Expression;trafficking;Training;transcriptome;transcriptomics;tutoring;vesicular release;vocal learning;vocalization;zebra finch

PROJECT_TITLE: The role of experience during the critical period for the development of vocal motor circuits


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: Antimicrobial-resistant and healthcare-associated pathogens are a global health threat. The goals of antimicrobial stewardship are to minimize unnecessary and inappropriate antimicrobial use as a means to combat antimicrobial resistance. Previously, we implemented a Videoconference Antimicrobial Stewardship Team (VAST) at 2 VA Medical Centers (VAMCs), using telehealth to connect clinicians at a rural VAMC to a geographically distant infectious disease expert Both VASTs successfully decreased overall antibiotic use in acute and long-term care units. This project will expand the VAST approach to other VAMCs and test the hypothesis that quarterly reports that quantify facility-level antibiotic use will enhance the efficacy of VASTs to support antimicrobial stewardship. This work will directly increase access to antimicrobial stewardship consultation at rural VA facilities, which are often underserved by infectious disease expertise.

PI_NAMEs: EVANS, CHARLESNIKA T;JUMP, ROBIN  (contact)

PROJECT_TERMS: Acute;Address;Administrator;Advisory Committees;Affect;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Resistance;Area;care outcomes;care providers;Caring;Cellulitis;Cessation of life;Clinical;clinical care;Clinical effectiveness;Clinical Pharmacists;Clinical Practice Guideline;Collaborations;combat;Communicable Diseases;Community Healthcare;Complex;Consultations;Cost Analysis;COVID-19;Data;design;Development;Dissemination and Implementation;Effectiveness;effectiveness/implementation design;evidence base;evidence based guidelines;Evidence based intervention;experience;feasibility testing;Feedback;geographically distant;global health;Goals;Guidelines;Health;Health Services;Health Services Accessibility;Healthcare;Healthcare Systems;healthcare-associated infections;implementation barriers;implementation cost;implementation evaluation;Improve Access;improved;Individual;Infection;Infection Control;innovation;interest;Intervention;Interview;Length;Long-Term Care;Maps;Measures;Medical center;medical specialties;member;Mentors;Methodology;Methods;military veteran;Modeling;Modification;multidisciplinary;novel coronavirus;novel strategies;Nurses;operation;Outcome;Outcome Measure;Outpatients;Participant;pathogen;Patient Care;patient safety;patient subsets;peer;Perception;Pharmacists;pharmacy benefit;Physicians;Pilot Projects;Pneumonia;Policy Maker;prevent;Prevention;primary outcome;Process;programs;Provider;Quality of Care;Randomized;Recommendation;Reporting;Resources;Risk Factors;Role;Rural;Rural Health;secondary outcome;Services;Site;Specialist;Structure;System;Teleconferences;telehealth;Testing;Training;United States Department of Veterans Affairs;Urinary tract infection;Veterans;videoconference;Work

PROJECT_TITLE: Dissemination and Implementation of a Videoconference Antimicrobial Stewardship Team (VAST)

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Despite efforts to implement universal HIV testing in the United States, late HIV diagnosis—diagnosis at an advanced stage of infection—remains highly prevalent, contributes to increased morbidity and mortality among people with HIV as well as transmission of infection, and is a priority to address to end the HIV epidemic. The proposed research will provide a fuller understanding of 1) the current demographic, behavioral, and psychosocial health disparities associated with late diagnosis using a large public health surveillance dataset; 2) the longitudinal HIV clinical outcomes (e.g. viremia and CD4 count) post-late diagnosis; 3) the clinical significance of different definitions of late diagnosis on longitudinal outcomes and factors associated with different definitions; 4) reasons for late diagnosis and lack of engagement in healthcare not captured in routine surveillance and survey data, and 5) the influence of alcohol specifically on the late diagnosis and HIV outcomes. The results of this research can inform impactful interventions and policies to reduce late diagnosis by identifying health disparities and multidimensional barriers to and missed opportunities for HIV testing and engagement in healthcare.

PI_NAMEs: PARISI, CHRISTINA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: access disparities;Address;Affect;Alcohol consumption;alcohol effect;alcohol research;Alcohols;Area;Award;Behavioral;career;Caring;CD4 Lymphocyte Count;Cells;Characteristics;Clinical;clinically significant;Collection;Communicable Diseases;Communities;Consensus;Data;Data Set;Diagnosis;Dimensions;Disease Progression;Disparity;Epidemic;Epidemiologic Methods;Epidemiologist;epidemiology study;Fellowship;Florida;Foundations;Goals;Guidelines;Health;health care availability;health data;health disparity;Healthcare;Heavy Drinking;high risk;HIV;HIV diagnosis;HIV/AIDS;Human immunodeficiency virus test;improved;Incidence;Individual;Infection;interdisciplinary approach;Intervention;Interview;Lead;Learning;Link;Literature;longitudinal analysis;Manuscripts;Measures;Medical;Mentors;Methods;Modeling;Modification;Monitor;Morbidity - disease rate;mortality;National Institute on Alcohol Abuse and Alcoholism;National Research Service Awards;Outcome;Participant;Pattern;Persons;Phase;Policies;Population;Population Surveillance;Postdoctoral Fellow;pre-doctoral;Production;psychosocial;Public Health;recruit;Registries;Reporting;Research;Research Activity;Risk;Science;Scientist;skills;social;social factors;Statistical Methods;Strategic Planning;structural determinants;Structure;substance use;Surveys;System;Testing;Training;Training Activity;transmission process;United States;Viral Load result;Viremia

PROJECT_TITLE: The impact of health disparities and alcohol use on late diagnosis of HIV in Florida: Understanding missed opportunities using a statewide dataset


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Neurosciences;Opioids;Pain Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Narrative Our focus on the kappa opioid system is justified by the growing appreciation of the therapeutic potential of selective kappa agonists and antagonists in the treatment of pain, affective disorders, and addiction. We will apply structural and pharmacological approaches to comprehensively characterize the structural basis that governs KOR ligand selectivity, receptor activation and signaling. The long-term goal is to leverage these data to generate new chemical matter for therapeutic applications.

PI_NAMEs: CHE, TAO  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: abuse liability;addiction;Agonist;Analgesics;antagonist;Arrestins;Behavior;beta-arrestin;Binding;Cause of Death;Cessation of life;Chemicals;Clinical Treatment;Clinical Trials;Complex;Cryoelectron Microscopy;Data;design;drug discovery;Drug Targeting;G-Protein-Coupled Receptors;Goals;GTP-Binding Proteins;Heterotrimeric GTP-Binding Proteins;Human Genome;in vivo;Individual;insight;kappa opioid receptors;Ligands;Mental Depression;Molecular;Mood Disorders;Morphine;mu opioid receptors;novel;novel therapeutics;Opioid;Opioid agonist;Opioid Antagonist;Opioid Receptor;Overdose;Oxycodone;Pain;Pain management;pain sensation;Pathway interactions;pharmacologic;Pharmacology;receptor;Receptor Activation;Receptor Signaling;Research;respiratory;Role;scaffold;side effect;Signal Transduction;structural determinants;Structure;System;Therapeutic;Transducers;X-Ray Crystallography

PROJECT_TITLE: Structural Determinants of Kappa Opioid Receptor Signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_STATE: TX

PHR: Project narrative:  α7 nicotinic acetylcholine receptors are widely expressed and play a role in numerous human diseases including Alzheimer’s disease, schizophrenia, and inflammation. Despite promising preclinical evidence for α7 targeted molecules, clinical trials have been largely unsuccessful. This proposal aims to answer key questions surrounding α7 structure-function, improve our understanding of α7 pharmacology, and provide a basis for future rational drug design.

PI_NAMEs: BURKE, SEAN MICHAEL (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: addiction;Affinity;Affinity Chromatography;alpha-bungarotoxin receptor;Alzheimer's Disease;Animal Model;Anxiety Disorders;Binding;Binding Sites;Biology;brain tissue;Cells;Characteristics;Chemical Structure;Chemosensitization;Classification;Clinical Trials;Complex;Cryoelectron Microscopy;Data;desensitization;Development;Disease;Doctor of Philosophy;Drug Binding Site;Drug Design;drug development;Effectiveness;Exhibits;experience;experimental study;Family;Foundations;Future;Goals;holistic approach;Homo;human disease;Impaired cognition;improved;in vivo;Inflammation;Ion Channel Gating;Left;Ligands;Link;Mediating;Methods;Molecular Conformation;Molecular Structure;Muscle;Nervous System;Neurodegenerative Disorders;Neurons;neurotransmission;Neurotransmitters;Nicotinic Receptors;Parkinson Disease;particle;Permeability;Pharmacology;Play;positive allosteric modulator;pre-clinical;preservation;Property;Proteins;receptor;Recombinants;Research;Resolution;Role;Schizophrenia;Signal Transduction;Source;stoichiometry;Structure;success;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;Training;Work

PROJECT_TITLE: alpha7 nicotinic acetylcholine receptor allosteric modulation and native structure


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: The proposed research is relevant to public health because it will identify diagnostic biomarkers and therapeutic targets for the treatment of invasive mucinous adenocarcinoma of the lung (a malignant type of lung cancer) causing several thousand deaths every year in the US. Thus, the proposed research is relevant to the mission of the NIH to acquire new knowledge that will help to diagnose and treat human diseases.

PI_NAMEs: MAEDA, YUTAKA  (contact);SNYDER, ERIC LEE

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: 3-Dimensional;Adenocarcinoma;Appendix Adenocarcinoma;autocrine;Biological Markers;Biology;biomarker identification;Boston;Cancer Etiology;Cancer Patient;Candidate Disease Gene;Cell Communication;Cell Line;cell type;Cells;Cellular Morphology;Cessation of life;Cities;Classification;Data;Development;Diagnosis;diagnostic biomarker;driver mutation;effective therapy;Epidermal Growth Factor Receptor;Europe;Evaluation;gastrointestinal;Gastrointestinal tract structure;Gene Expression;Genes;Genetic;genetic analysis;genetic signature;Goals;Goblet Cells;Growth;Heterogeneity;Histology;HNF4A gene;Human;human disease;Immune;Immunohistochemistry;Immunotherapy;In Vitro;in vivo;innovation;Iowa;Japan;Knowledge;KRAS2 gene;KRASG12D;Lung;Lung Adenocarcinoma;Lung Neoplasms;Malignant - descriptor;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Metastatic Neoplasm to the Lung;Mission;Molecular;Molecular Analysis;molecular targeted therapies;Morphology;mouse model;Mucinous;Mucinous Neoplasm;Mucins;Mucous body substance;Mutation;neoplastic cell;new technology;new therapeutic target;New York City;next generation sequencing;novel therapeutics;Nuclear Receptors;Oncologist;Organ;Organoids;Outcome;Pancreatic Adenocarcinoma;Papillary;paracrine;Pathologic;Pathologist;Pathway interactions;Patients;Pharmaceutical Preparations;programmed cell death ligand 1;programs;Public Health;Reporting;Research;Research Personnel;single cell mRNA sequencing;single-cell RNA sequencing;small molecule;small molecule inhibitor;Sodium Chloride;Solid;Specimen;Stromal Cells;Surgeon;Testing;Therapeutic;Therapeutic antibodies;therapeutic biomarker;therapeutic target;tumor;tumor microenvironment;United States National Institutes of Health

PROJECT_TITLE: Patho-Genetic Analysis of Invasive Mucinous Adenocarcinoma of the Lung

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Genetics

PHR: Project Narrative RNA localization and modification play a key role in cellular functions including development, immune response, and motility, and are frequently dysregulated in disease. This research will develop a suite of technologies to study and control localization and editing, as well as the interplay between these pro- cesses, which will aid in the development of new diagnostic and therapeutic approaches.

PI_NAMEs: HEEMSTRA, JENNIFER MARGARET (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Address;biological systems;Biology;Cell Physiology;Cells;Chemicals;Communities;Development;Disease;DNA;Event;Future;genetic information;Genetic Transcription;Image;Immune response;improved;insight;Label;Methods;Modification;Motility;novel diagnostics;novel therapeutic intervention;novel therapeutics;Play;Post-Transcriptional RNA Processing;posttranscriptional;Process;programs;Proteins;Regulation;Reporting;Research;Research Personnel;RNA;Role;Technology;technology validation;Transcript;Translating;Translations;Untranslated RNA

PROJECT_TITLE: A chemical biology toolbox for RNA post-transcriptional modification and capture

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Heart Disease;Hematology;Neurosciences;Stroke

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE In this project our goal is to use computer modeling and medical imaging to better understand why some people experience stroke. We will create a new infrastructure that reads in a patient’s MRI scans then outputs an accurate and custom-tailored measurement of stroke risk based on simulations of structure, electrical activity, contraction, and blood flow in their heart. Through this work we hope to better understand links between disease- related changes to the heart (i.e., fibrosis), abnormal heart rhythms, and clotting events that lead to stroke.

PI_NAMEs: BOYLE, PATRICK M (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: 3-Dimensional;Address;adverse outcome;Affect;American;Anatomy;Anticoagulation;appendage;Arrhythmia;Atrial Fibrillation;Attention;Attenuated;bioelectricity;Biomechanics;Blood flow;Brain;brain magnetic resonance imaging;Calibration;Cardiac;cerebral microinfarct;Cine Magnetic Resonance Imaging;Clinical;Clinical Research;clinical risk;Coagulation Process;cohort;Collagen;Communities;comorbidity;Complex;computer framework;Computer Models;Custom;Data;demographics;Deposition;Diagnosis;Disease;Electrophysiology (science);Elements;embolic stroke;Enrollment;Equipoise;Evaluation;Event;experience;Experimental Designs;Fibrosis;follow-up;Gadolinium;Goals;Heart;Heart Abnormalities;Heart Atrium;heart rhythm;hemodynamics;Hemorrhage;high risk;Image;improved;Individual;Infrastructure;innovation;insight;Ischemic Stroke;Knowledge;Left;Link;Magnetic Resonance Imaging;Maps;Measurement;Measures;Mediating;Medical Imaging;Modeling;Morbidity - disease rate;mortality;Motion;MRI Scans;multimodality;Muscle Cells;Oral;Outcome;Output;Patients;Pattern;Persons;Phase;Physics;Populations at Risk;Predisposition;prospective;recruit;Recurrence;Risk;Risk Estimate;risk stratification;Role;Running;Shapes;simulation;Source;Stroke;Stroke prevention;stroke risk;stroke therapy;structural determinants;Structure;Testing;thromboembolic stroke;Thromboembolism;thrombogenesis;Thrombosis;Thrombus;Time;tool;Validation;Work

PROJECT_TITLE: Mechanistic Relationships Between Fibrosis, Fibrillation, and Stroke: Multi-Scale, Multi-Physics Simulations

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Telehealth;Transplantation

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE In the United States, poor adherence accounts for up to 70% of all medication-related hospital admissions and an estimated 50-80% of pediatric patients are non-adherent. Behavioral economics (BE) suggests that small “nudges” or reminders can produce and sustain behavior change, thus with mobile health (mHealth) access nearly ubiquitous and an estimated 3.7 billion mHealth application downloads in 2017 alone,13 technology has great potential to improve adherence. Nurses could easily deliver these universal mHealth intervention approaches as a frontline approach to family education and care, addressing the critical need to improve adherence and clinical outcomes among children to ultimately prevent morbidity and mortality.

PI_NAMEs: SKEENS, MICAH  (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Acute;Address;Adherence;adherence rate;Age;behavior change;behavioral economics;Biological Assay;Care given by nurses;Caregivers;Caring;Child;Child Care;Childhood;Chronic Disease;Clinical;Clinical Investigator;Cystic Fibrosis;design;Development;Diabetes Mellitus;Doctor of Philosophy;Education;efficacy evaluation;efficacy trial;Enrollment;experience;Family;formative assessment;Frequencies;Goals;graft vs host disease;Health Care Costs;Hematopoietic Stem Cell Transplantation;Home;hospital readmission;Hospitalization;Immunosuppression;Immunosuppressive Agents;improved;improved outcome;indexing;innovation;International;Intervention;Interview;Knowledge acquisition;Measures;Mediator;Mentorship;Methods;mHealth;mhealth interventions;Mobile Health Application;Morbidity - disease rate;mortality;novel;Nurses;Organ Transplantation;Outcome;Outpatients;Participant;Patient Noncompliance;Patient Self-Report;Patients;pediatric patients;Pediatrics;Pharmaceutical Preparations;Phase;Pilot Projects;Population;Positioning Attribute;post-transplant;prevent;primary outcome;Process;programs;Provider;Randomized;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Research Training;Science;Scientist;secondary outcome;Serum;sex;Site;Socioeconomic Status;Solid;Structure;successful intervention;systematic review;Technology;technology intervention;Testing;therapy development;Time;Training;Transplant Recipients;treatment as usual;treatment duration;Treatment Protocols;United States;universal prevention;usability;Work

PROJECT_TITLE: Improving adherence through mHealth for pediatric hematopoietic stem cell transplant patients

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(78)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Heart Disease;Mental Health;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Sleep Research;Transplantation;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Delirium is terrifying, costs an estimated $164 billion annually in the US alone and is associated with a greater risk of death, institutionalization, and Alzheimer’s disease and related dementias (ADRD); ADRD, in turn, affects more than 5 million Americans and exacts an incalculable human toll. Sleep-wake disturbance (SWD) is an observable, measurable, and potentially modifiable aspect of both delirium and ADRD. It may offer novel opportunities to prevent and treat delirium as well as to mitigate the development of subsequent ADRD. This project aims to examine home-based measures of SWD as physiological markers for delirium risk in aortic valve surgery patients while serving as a vehicle for career development for the PI to become an independent physician-scientist in delirium pathophysiology and its relation to ADRD.

PI_NAMEs: OLDHAM, MARK ALAN (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: actigraphy;Adult;Affect;Age;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;American;aortic valve;aortic valve replacement;Apnea;Biological Markers;Blood Vessels;Cardiac Surgery procedures;career;career development;Caring;Cerebrovascular Disorders;circadian;Clinical;Cognition;Cognitive;cohort;Consultations;cost estimate;Delirium;demographics;design;Development;Enrollment;Environmental Exposure;experience;Family;FDA approved;Foundations;Functional disorder;functional outcomes;glymphatic clearance;glymphatic dysfunction;Goals;Guidelines;High Prevalence;high risk;Home;Hospitals;Hour;Human;Impaired cognition;improved;Incidence;indexing;Individual;insight;Institutionalization;Interdisciplinary Study;interest;Intervention;Investigation;Light;Link;Longitudinal Studies;Measurable;Measures;Medicine;Mental Health;Methods;Mission;Morbidity - disease rate;mortality risk;neurocognitive disorder;Neuropsychological Tests;Neuropsychology;novel;older adult;Operative Surgical Procedures;Outcome;Pathogenesis;Pathology;Patients;Perioperative;Physicians;Physiological;Pilot Projects;Play;postoperative delirium;Postoperative Period;prevent;Prevention trial;programs;Prospective, cohort study;Provider;Psychiatrist;Public Health;Research;Resources;Rest;Risk;Risk Factors;risk stratification;Role;Science;Scientist;Severities;Signal Transduction;Sleep;Sleep Apnea Syndromes;Sleep Architecture;sleep physiology;Solid;Statistical Methods;statistics;Study Subject;System;Testing;Time;Training;translational potential;treatment trial;trend;Vascular Dementia;Vulnerable Populations;wearable device

PROJECT_TITLE: Sleep-Wake Disturbance as a Predictor of Delirium and Subsequent Alzheimer's Disease and Related Dementias after Surgical Aortic Valve Replacement

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Bioengineering;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ANN ARBOR

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Cell-cell communication through signaling controls cell behavior from embryonic development to adult tissue renewal and is fundamental to health. This proposal will improve our understanding of the complex signaling inputs that instruct human pluripotent stem cells to differentiate into specific cell types. The resulting data will provide new insight into how cells interpret combinatorial signals over time, which can be exploited to improve a wide range of disease treatments and aid efforts toward stem cell-based therapies.

PI_NAMEs: HEEMSKERK, IDSE JOANNES (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Activins;Adhesions;Adult;Biological Assay;Biophysics;cell behavior;Cell Communication;Cell Fate Control;Cell Line;cell type;Cells;Characteristics;combinatorial;Complex;Computer Analysis;Computer software;Custom;Data;Data Science;Disease;Drug Targeting;Drug usage;Embryonic Development;engineered stem cells;Environment;epithelial to mesenchymal transition;Fibroblast Growth Factor;Fluorescence Microscopy;Foundations;Gene Combinations;Gene Expression;Goals;Health;Homeostasis;human pluripotent stem cell;Image Analysis;improved;Individual;insight;interdisciplinary approach;Knowledge;Laboratories;Link;Logic;Maintenance;mathematical model;Measurement;Measures;mechanical signal;Mechanics;Mesoderm;Methods;multidimensional data;Nodal;nonbinary;notch protein;paracrine;Pathway interactions;Play;pluripotency;Population;Protocols documentation;Publishing;Recording of previous events;Research;response;Role;Signal Pathway;Signal Transduction;Signaling Molecule;stem cell differentiation;stem cell therapy;Therapeutic;Time;tissue regeneration;Tissues;Visualization;Work

PROJECT_TITLE: Decoding the non-binary signaling logic that controls cell fate

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Clinical Research;Data Science;Physical Activity;Prevention

PHR: PROJECT NARRATIVE This project aims to develop a sustainable research infrastructure built on the foundation of a smart watch app (ROAMM: Real-time Online Assessment and Mobility Monitor). We will use continuous and remote health monitoring from wearable technology to understand risk factors and impact of falls and hospitalizations.

PI_NAMEs: MANINI, TODD  (contact);RANKA, SANJAY

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acceleration;Accelerometer;Address;Adherence;Adopted;advanced analytics;Adverse event;Advisory Committees;aged;American;Apple watch;Area;Automobile Driving;base;Behavioral;Capsicum;Charge;Clinical;Cognition;cognitive testing;Collaborations;Communities;comorbidity;cost effectiveness;Data;Data Collection;Data Science;data science management;Data Storage and Retrieval;data to knowledge;data visualization;demographics;depressive symptoms;disability;Early Diagnosis;Ecological momentary assessment;Ensure;Event;executive function;experience;fall injury;fall risk;falls;Fatigue;Fees;Florida;Focus Groups;focus ultra;Foundations;Frequencies;Geriatrics;Gerontology;Grant;graphical user interface;Health;Heart Rate;Home;Hospitalization;Incidence;informant;Infrastructure;Injury;Interview;Licensing;Life;Location;Longitudinal cohort study;longitudinal, prospective study;Marketing;Measurement;Measures;Medical;mobile computing;mobile sensor;Modeling;Monitor;Moods;Nature;novel;older adult;Online Systems;Outcome;Pain;Participant;Patient Outcomes Assessments;Patients;Pattern;Persons;Phase;Phenotype;Physical activity;Physical Function;Prevention;primary outcome;processing speed;prospective;Quality of life;Recording of previous events;Recovery;recruit;Remote management;remote patient monitoring;Reporting;Research;Research Infrastructure;Research Personnel;response;Risk;Risk Factors;Safety;Science;secondary outcome;Secure;sensor;Services;Short-Term Memory;smart watch;Symptoms;System;Technology;technology platform;Testing;therapy design;Time;tool;United States National Institutes of Health;Universities;usability;Voice;walking speed;wearable device;wearable monitor;week trial;Work

PROJECT_TITLE: Wearable Technology Infrastructure to Enhance Capacity for Real-Time, Online Assessment and Mobility (ROAMM) of Intervening Health Events in Older Adults

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


PHR: Projective Narrative Diabetes and obesity increase the toxic lipid accumulation in the heart and increase the risk of developing heart failure. The mechanisms through which lipids cause heart injury is unclear, and thus there are no available therapies targeting this process. I propose to study the role of lysosomal biogenesis and function in cardiac lipid overload, with the goal of developing therapies to improve this condition and prevent heart failure.

PI_NAMEs: RAWNSLEY, DAVID  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Age;Animal Model;Area;Atherosclerosis;Attenuated;Autophagocytosis;Biogenesis;Biology;Cardiac;Cardiac Myocytes;Cardiology;Cardiomyopathies;Cardiovascular system;career;career development;Cells;Ceramides;Cessation of life;clay;clinical training;Coenzyme A Ligases;Data;Development;Development Plans;Diabetes Mellitus;diabetic cardiomyopathy;diet-induced obesity;dihydroceramide desaturase;Disease;Doctor of Philosophy;Echocardiography;Environment;Enzymes;Epidemic;epidemiology study;Etiology;experimental study;Functional disorder;Gene Expression;Goals;Grant;Heart;Heart Diseases;Heart failure;heart function;Heart Injuries;High Fat Diet;Human;Hypertrophy;Immunoprecipitation;Impairment;improved;in vivo;Individual;Institution;Intermittent fasting;Intervention;Ischemia;Joints;knock-down;Knowledge;Laboratories;Leadership;Left Ventricular Dysfunction;lipidomics;Lipids;loss of function;Lysosomes;Mediating;Medicine;Mentors;Mentorship;Modeling;Molecular and Cellular Biology;mortality;mouse model;Mus;Myocardial;Myocardial dysfunction;Myocardial Ischemia;novel;Nuclear;Obesity;Outcome;overexpression;Oxidative Stress Induction;Palmitates;Pathology;Pathway interactions;Patients;Phenotype;Physicians;Physiological;Population;post-doctoral training;Prevalence;prevent;Process;programs;protein aggregation;Proteins;Reperfusion Injury;Research;Research Personnel;Research Support;response to injury;Risk;Risk Factors;Role;Scientist;skills;Small Interfering RNA;Sphingolipids;Stress;System;targeted treatment;Testing;therapy development;Training;transcription factor;Transcriptional Activation;Transgenic Mice;trend;Triglycerides;Up-Regulation;Wild Type Mouse;Writing

PROJECT_TITLE: Targeting Lysosome Function in Lipid Overload Cardiomyopathy

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Prevention;Screening and Brief Intervention for Substance Misuse;Substance Misuse;Underage Drinking;Violence Research;Youth Violence

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Alcohol-induced “blackouts” – or memory loss for events that occur while one is drinking – are prevalent among young adults and reliable predictors of alcohol-related harm. The proposed study will test the feasibility and initial efficacy of a dynamic personalized feedback intervention in reducing heavy drinking and alcohol- related consequences among young adults (18-30y) with a history of blackout. Findings will inform future research and clinical practice by documenting the utility of the intervention in reducing the health, social, and economic burden of alcohol use among young adults.

PI_NAMEs: MILLER, MARY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: acceptability and feasibility;Age;Alcohol abuse;alcohol consequences;Alcohol consumption;alcohol intervention;alcohol related consequences;alcohol related problem;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;Awareness;Behavior;Blood alcohol level measurement;brief alcohol intervention;brief intervention;clinical practice;Communities;cost;Costs and Benefits;Data;depressive symptoms;design;deter alcohol use;drinking;drinking behavior;Economic Burden;efficacy evaluation;efficacy testing;Emergency department visit;Evaluation;Event;experience;feasibility testing;Feedback;Female;follow-up;Frequencies;Goals;group intervention;Health;Health behavior;Heavy Drinking;heavy drinking young adult;high intensity drinking;high risk;high risk drinking;Incidence;Individual;Injury;innovation;interest;Intervention;intervention cost;intervention participants;intervention refinement;Language;Link;Mediator;Medical Care Costs;Memory Loss;men;Moods;mortality;Motivation;National Institute on Alcohol Abuse and Alcoholism;novel;Outcome;Participant;Pattern;Perception;Pharmaceutical Preparations;Phase;pilot test;post intervention;preventive intervention;primary outcome;prospective;prototype;public health relevance;Randomized;randomized trial;Randomized, Controlled Trials;Reaction;Recording of previous events;recruit;Reporting;Research;response;revictimization;Sampling;secondary outcome;Self Efficacy;Severities;sexual coercion;Sleep;social;Speed;Strategic Planning;Testing;Treatment Efficacy;Variant;Woman;young adult

PROJECT_TITLE: Dynamic Personalized Feedback for Young Adults with a History of Alcohol-Induced Blackout

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Bioengineering;Genetics

PHR: NARRATIVE This project uses biophysical measurements to determine the mechanisms of molecular machines that are used in gene editing applications or are targets of antibacterial drugs. Using newly developed single-molecule approaches, CRISPR- Cas9 and related enzymes will be observed in real time as they unwind DNA, search for matches with a guide RNA molecule, and selectively cleave their DNA substrate. The same approaches will be applied to determine how DNA gyrase enzymes from pathogenetic bacteria harness ATP hydrolysis to wind up the genome.

PI_NAMEs: BRYANT, ZEV  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Affect;Anti-Bacterial Agents;ATP Hydrolysis;Back;Bacteria;Base Pairing;Binding;Binding Proteins;Biological;Biology;biophysical model;biophysical properties;Biophysics;Biotechnology;Catalytic Domain;Chemicals;Complex;Coupled;Coupling;CRISPR/Cas technology;Cryoelectron Microscopy;DNA;DNA Gyrase;ds-DNA;Environmental Wind;Enzymes;Escherichia coli;Event;experience;Fluorescence;Fluorescence Resonance Energy Transfer;Genes;Genetic;Genetic Transcription;Genome;Grant;Growth;Guide RNA;Holoenzymes;Hydrolysis;insight;Kinetics;Length;macromolecular assembly;Maps;Measurement;Measures;mechanical properties;Mechanics;method development;Methods;Molecular;Molecular Conformation;Molecular Machines;Monitor;Motor;multimodality;Mycobacterium tuberculosis;nanoGold;nuclease;Nucleic Acids;Nucleoproteins;Nucleosomes;Nucleotides;Pharmaceutical Preparations;Physiological;pressure;Process;Property;Proteins;Protocols documentation;Regulation;Resolution;response;RNA;single molecule;Site;Structure;success;Superhelical DNA;System;Testing;Time;Torque;Torsion;Vertebral column;Visualization;Work

PROJECT_TITLE: Structural Dynamics and Mechanochemical Coupling in Nucleoprotein Machines


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioids;Substance Misuse

PHR: PROJECT NARRATIVE Chronic stress is a prominent factor in the development of aberrant reward-seeking behavior in disorders like substance use disorder which affect an alarming proportion of the global population, yet we lack a basic understanding of the innate neurocircuitry that are disrupted by stress exposure which subsequently alters motivation to seek rewards. We have recently identified a nociceptin neuropeptide and receptor circuit that suppresses reward-seeking and increases aversion, central components of approach-avoidance behavior. The goal of this proposal is to investigate how the endogenous ventral tegmental area nociceptin opioid circuit is engaged by diverse forms of stress exposure to regulate the expression of approach-avoidance behaviors, opening new avenues for exploring nociceptin receptors as a viable therapeutic target for reward-related disorders.

PI_NAMEs: STINE, CAROLYN ANN (contact)

PROJECT_TERMS: Acute;acute stress;addiction;Address;Affect;Anatomy;Anxiety;approach behavior;approach/avoidance behavior;Automobile Driving;Behavior;Behavioral Model;biological adaptation to stress;Biosensor;Brain;career;career development;Cells;Chronic;Chronic stress;Clinical Trials;Color;Complex;conditional knockout;Data;Decision Making;Depressive disorder;Detection;Development;Development Plans;Disease;dopaminergic neuron;early life adversity;Electrophysiology (science);endogenous opioids;experience;Exposure to;Fiber;Fluorescent in Situ Hybridization;foot;G-Protein-Coupled Receptors;Goals;Head;Histology;Hypothalamic structure;Immunohistochemistry;improved;in vivo;Individual;Industry;innovation;insight;Investigation;Label;Laboratories;Lateral;Learning;Ligands;Link;Major Depressive Disorder;Mediating;Mental Depression;Mentors;Messenger RNA;Modeling;Molecular;molecular targeted therapies;motivated behavior;Motivation;Mus;National Institute of Drug Abuse;neural circuit;Neurons;Neuropeptides;neurotransmission;nociceptin;novel strategies;novel therapeutics;Opioid;Opioid Peptide;Optics;optogenetics;ORL1 receptor;Pathogenesis;Peptides;Photometry;physiologic stressor;Physiological;Population;Predisposition;prepronociceptin;Process;Property;Proteins;psychologic;Psychological Stress;psychological stressor;receptor;receptor expression;Receptor Signaling;Relapse;Reporting;Research;Resolution;response;restraint;Rewards;Role;Scientist;Shock;Signal Pathway;Signal Transduction;skills;Slice;Stress;stress reactivity;stress state;stressor;Substance Use Disorder;Synapses;System;Techniques;Testing;therapeutic target;Training;Ventral Tegmental Area

PROJECT_TITLE: Dissecting stress modulation of pnVTA nociceptin peptide-mediated approach-avoidance behavior


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Helminth infections and allergic disorders pose a significant public health burden. The common factor in these illnesses is that they both induce type 2 immunity, the hallmark of which is the development of CD4+ helper type 2 cells. In this proposal, we aim to better understand the metabolic regulation of these cells as such knowledge may facilitate the design of therapeutic approaches for inhibiting or potentiating type 2 immunity.

PI_NAMEs: KANIA, ANNA K. (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acyl Coenzyme A;Adipose tissue;Affect;Allergens;Allergic;allergic response;Animals;Asthma;Biological Assay;Biology;CD4 Positive T Lymphocytes;Cell Count;Cell Physiology;Cell secretion;Cells;Cellular Assay;Chromatin;Coenzyme A Ligases;Colon;Complex;County;cytokine;Data;design;Development;Disease;Disease Progression;Enzymes;Epidermis;Failure;fatty acid metabolism;fatty acid oxidation;fatty acid-transport protein;Fatty Acids;Fibroblasts;Flow Cytometry;Food Hypersensitivity;Frequencies;GATA3 gene;Gene Expression;Genes;Genetic Transcription;genome-wide;Greater sac of peritoneum;helminth infection;human model;Hypersensitivity;Immune;Immune response;Immunity;Immunophenotyping;Impairment;Infection;insight;Interleukin-4;Interleukin-5;Intestines;Knock-out;Knowledge;Lead;Ligands;Link;lipid metabolism;lipidomics;Lipids;Mediating;mesenteric lymph node;Mesentery;Metabolic;metabolomics;Modeling;Molecular;mouse model;Mouse Strains;Mus;Nematoda;Nematospiroides dubius;next generation sequencing;Nonesterified Fatty Acids;novel;novel therapeutic intervention;oxidation;Parasites;pathogen;Pathogenicity;Persons;Phenotype;Play;Population;PPAR gamma;Proteins;Public Health;Publishing;Regulation;Resistance;Resistance to infection;response;restraint;Role;Severities;Skin;Small Intestines;T-Cell Activation;T-Lymphocyte;Techniques;Testing;Th2 Cells;Therapeutic;Tissues;transcription factor;transcriptome;Work

PROJECT_TITLE: Regulation of tissue-resident helper type 2 T cells by fatty acid transport protein 4 (FATP4)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07B-U(20)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Our project entitled “Impacts of structural racism on racial and ethnic disparities in perinatal health” will leverage established partnerships among Baylor College of Medicine, UTHealth McGovern Medical School, and Texas Southern University through our NIMHD/NIEHS/NICHD P50 Center of Excellence on Environmental Health Disparities Research to conduct a retrospective cohort study using electronic health records from major labor and delivery hospitals serving women in the third largest county in the nation (Harris County, Texas) that includes the city of Houston. We will assess the independent effects of structural racism across five domains on racial/ethnic disparities in both maternal morbidity (hypertension in pregnancy and gestational diabetes) and adverse pregnancy outcomes (low birth weight and preterm birth), explore whether combined exposures to multiple domains of structural racism enhance disparities, and apply machine learning methods to identify the key structural racism predictors of adverse perinatal health outcomes.

PI_NAMEs: SYMANSKI, ELAINE ;WHITWORTH, KRISTINA WALKER (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: adverse outcome;adverse pregnancy outcome;Air Pollution;American College of Obstetricians and Gynecologists;Behavior;Bioinformatics;Biometry;Birth;Black race;black women;Cities;college;Color;Communities;community burden;Complex;County;Criminal Justice;Discipline of obstetrics;Discrimination;Disparity;economic cost;Electronic Health Record;Environmental Epidemiology;Environmental Exposure;environmental health disparity;ethnic disparity;Etiology;experience;Exposure to;follow-up;Foundations;Future;Genetic;Gestational Diabetes;Hazardous Waste Sites;Health;Health Disparities Research;health disparity;health inequalities;Health Services Accessibility;high risk;Hispanic;Hispanic Women;Hospitals;Housing;Hypertension;Imprisonment;improved;Industry;Infant;Intervention;Joints;Life Cycle Stages;Low Birth Weight Infant;machine learning method;Maternal and Child Health;maternal hypertension;maternal morbidity;Maternal-fetal medicine;medical schools;Medicine;Mexican;Mothers;National Institute of Child Health and Human Development;National Institute of Environmental Health Sciences;National Institute on Minority Health and Health Disparities;Neighborhoods;Not Hispanic or Latino;Outcome;people of color;Perinatal Epidemiology;perinatal health;perinatal outcomes;Personal Satisfaction;Police;Policies;Pregnancy;Pregnancy in Diabetics;Pregnancy Outcome;Pregnant Women;Premature Birth;Prevalence;Property;racial disparity;racism;Reporting;Research;residential segregation;Resources;Retrospective cohort study;Risk;Role;segregation;Social Sciences;societal costs;soil pollution;Source;Stress;stressor;Structural Racism;System;Texas;Universities;Violence;Water Pollution;White Women;Woman;women of color;Women's cohort;Women's Health;women's outcomes;Work

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE HIV-1 associated neuroinflammation and neurotoxicity lead to cognitive impairments (HIV-1-associated neurocognitive disorders or HAND) even in those under suppressive antiretroviral therapy (ART). Using HIV-1 infected cerebral organoids from induced pluripotent stem cells, we will provide novel insights into the pathogenesis of HAND, Tat mediated neurotoxicity, effects of cocaine, and HIV-1 latency in the brain.

PI_NAMEs: NDHLOVU, LISHOMWA C;NIXON, DOUGLAS F (contact);VALENTE, SUSANA T

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adult;Affect;Age;age related;Aging;aging brain;Alkaloids;analog;antiretroviral therapy;Autologous;Bioinformatics;Brain;Brain region;CCL2 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell behavior;cell killing;Cell Line;Cell Physiology;Cells;Cellular Immunology;Cerebral cortex;Cerebrum;Cicatrix;Cocaine;cognitive testing;Collaborations;combinatorial;Complex;cortistatin;Cytotoxic T-Lymphocytes;Dementia;Development;disease model;Drug Addiction;drug of abuse;Drug Screening;Effectiveness;Effector Cell;Engineering;Exhibits;Exposure to;FOXO3A gene;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Goals;Hand;Healthcare Systems;Heterogeneity;hindbrain;Hippocampus;HIV;HIV-1;HIV-associated neurocognitive disorder;Human;Image;Immune;Impaired cognition;In Vitro;Individual;induced pluripotent stem cell;Infection;innovation;insight;Interdisciplinary Study;Interleukin-1 beta;Internet;Lead;Link;longevity gene;Mediating;Methods;Microglia;Microscopy;Modeling;Molecular Virology;mouse model;Nervous System Trauma;neural network;Neurocognitive Deficit;Neuroectoderm;Neuroglia;neuroimmunology;neuroinflammation;Neurons;neurotoxicity;nonhuman primate;novel;novel strategies;novel therapeutics;Organoids;Pathogenesis;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phenotype;Process;Prosencephalon;Reporter;Reproducibility;Residual state;Rewards;Role;Signaling Protein;single cell analysis;single-cell RNA sequencing;stem cell organoids;stem cell technology;stimulant abuse;Structure;Substance abuse problem;System;tat Protein;Technology;Testing;TNF gene;Toxic effect;transcriptome;transcriptome sequencing;uptake;Variant;Viral Proteins;Virus

PROJECT_TITLE: Development of Brain Organoids to Study the Impact of HIV-1, Drugs of Abuse and Aging on Cognitive Impairment


NIH_SPENDING_CATS: Clinical Research;Hematology;Orphan Drug;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: NARRATIVE  The efforts described in this grant will advance studies of platelets and the cells in the bone marrow from which they are derived. Proposed studies should provide new insights important for controlling bleeding and improving outcome in related medical disorders such as overwhelming sepsis. The insights from the proposed studies should also lead to new therapeutics like producing platelets to replace donor-based platelet transfusions and also expand usage of such platelets to treat other medical challenges like lysing undesired blood clots.

PI_NAMEs: PONCZ, MORTIMER  (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Affect;Antibodies;Area;Award;Beds;Benign;Biology;Blood coagulation;Blood Platelet Disorders;Blood Platelets;Bone Marrow;capillary bed;Career Mobility;Caring;Cells;chemokine;clinical application;Complementary DNA;Cytoplasmic Granules;Defect;Disease;extracellular;Factor VIII;Genes;Grant;Hematology;Hemophilia A;Hemorrhage;heparin-induced thrombocytopenia;improved outcome;In Situ;In Vitro;induced pluripotent stem cell;Inherited;inhibitor;insight;Integrins;interest;Intervention;leukemic transformation;Lung;Medical;Megakaryocytes;Megakaryocytopoieses;Modeling;Molecular;mouse model;National Heart, Lung, and Blood Institute;Nature;neutrophil;novel;novel therapeutics;Paris, France;Patients;PF4 Gene;Physiological;Platelet Transfusion;polyanion;PPBP gene;Process;Proteins;Research Personnel;Risk;Role;RUNX1 gene;Sepsis;Sickle Cell Anemia;Site;Syndrome;targeted treatment;Testing;Therapeutic;Thrombasthenia;Thrombocytopenia;thromboinflammation;Thrombopoiesis;Time;transcription factor;Urokinase;Variant;vascular injury

PROJECT_TITLE: New Mechanistic Insights & Therapeutic Applications of Megakaryocytes/Platelets


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: OTOLARYNGOLOGY

PHR: Project Narrative Encoding the amplitude modulations (AMs) in sound is a critical task of the auditory system, as AMs are important features of complex sounds such as human speech and other species-specific vocalizations. The inferior colliculus (IC) has been implicated as a site of transformation from temporal to rate coding of AM stimuli, however, the cellular and circuit mechanisms underlying how this process occurs remains largely unknown. The proposed research will determine how NMDA receptors facilitate the transformation from temporal to rate coding in IC neurons, providing fundamental insights into encoding mechanisms for AM stimuli that can be used to facilitate better interventions for those with hearing loss.

PI_NAMEs: DROTOS, AUDREY CLAIRE (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Address;AMPA Receptors;antagonist;Auditory;Auditory area;auditory pathway;Auditory system;awake;Brain;Brain region;Closure by clamp;Cochlear nucleus;Code;Complex;Data;Endowment;Excitatory Postsynaptic Potentials;Excitatory Synapse;Exhibits;experimental study;Frequencies;Glutamate Receptor;hearing impairment;Human;In Vitro;in vivo;Inferior Colliculus;insight;Intervention;Kinetics;Knowledge;Literature;Membrane Potentials;Midbrain structure;Modeling;Molecular;Mus;N-Methyl-D-Aspartate Receptors;Neurons;optogenetics;patch clamp;Pharmacology;Phase;phenomenological models;Play;Population;Process;Property;rate of change;receptor;Research;response;Rest;Role;Shapes;Site;Slice;sound;Speech;Stimulus;Structure;Synapses;Testing;Thalamic structure;Time;tool;Training;vocalization;voltage;Work

PROJECT_TITLE: Mechanisms Shaping Temporal Integration in the Inferior Colliculus