NIH_SPENDING_CATS: Clinical Research;Data Science;Kidney Disease;Machine Learning and Artificial Intelligence;Urologic Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Urinary stone disease is a common and painful condition with substantial morbidity. There have been few advancements in the diagnosis and management of urinary stone disease, which is due in part to lack of datasets that contain clinically important information about individuals with urinary stone disease across the lifespan. In this project, we create a data resource to strengthen urinary stone disease research that will generate new knowledge that improves the health of all individuals with urinary stone disease.

PI_NAMEs: HSI, RYAN  (contact);TASIAN, GREGORY EDWARD

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Back;Cardiovascular Diseases;Caregivers;Caring;Chemistry;Child;Child Health;Childhood;Chronic Kidney Failure;Clinic;Clinical;clinical care;clinical investigation;Clinical Research;Clinical Trials;cohort;Communities;comparative effectiveness study;Data;data access;data dictionary;data hub;data integration;data modeling;data resource;Data Science;Data Set;database design;Databases;density;design;Developmental Disabilities;Diagnosis;Disease;Ecosystem;Electronic Health Record;Emergency department visit;Ensure;Evaluation;Event;Exclusion;experience;Fracture;Funding;Future;Geography;Goals;Grant;Health;Health Care Costs;Health system;High Prevalence;Hour;Hypertension;improved;Individual;Inequity;Informatics;Kidney;Kidney Calculi;Kidney Diseases;Knowledge;Learning;life span;Link;Location;longitudinal care;Machine Learning;machine learning algorithm;machine learning method;Measurement;member;Mental disability;Metabolism;Methodology;Minerals;Modeling;Morbidity - disease rate;National Institute of Diabetes and Digestive and Kidney Diseases;Natural Language Processing;Nephrolithiasis;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Pain;Patient Care;Patients;physically handicapped;Population;Prevention;Primary Hyperoxaluria;Procedures;Process;Professional Organizations;Radiology Specialty;Recurrence;Reporting;Research;Research Personnel;research study;Resources;Risk;RNA Interference;Science;segregation;Site;Standardization;Strategic Planning;Structure;structured data;Testing;Treatment outcome;United States;unstructured clinical data;Urinary Calculi;Urine;Urologic Diseases;web site;Work;X-Ray Computed Tomography

PROJECT_TITLE: USDHub: community resource for Urinary Stone Disease research

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-M (M3)]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BETHLEHEM

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: LEHIGH UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative In the US, there are 7.3 million older adult immigrants (inclusive of refugees), and by 2060 the US’s older adult immigrant population is anticipated to increase to 22 million. Compared to other older adults in the general population, older refugees have poorer mental health. We propose an exploratory sequential mixed method community-based participatory research study to examine the mental health of older ethnic-Nepali Bhutanese refugees in central Pennsylvania and inform multi-level interventions to address the psychosocial functioning of aging refugees resettled in the US.

PI_NAMEs: FROUNFELKER, ROCHELLE LYNN (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Address;adolescent mental health;Adult;age group;aged;Aging;Anxiety;anxiety symptoms;Attention;Bhutan;Bhutanese;biopsychosocial;Canada;caregiver functioning;Caregivers;caregiving;Child Mental Health;Collaborations;Communities;community based participatory approach;community based participatory research;Community Integration;Country;depressive symptoms;Employment;Enrollment;ethnic minority population;Ethnic Origin;Evidence based intervention;experience;Exposure to;Family;Family Caregiver;Funding;General Population;Goals;Grant;health care availability;health disparity;Health Personnel;Immigrant;Immigration;Impaired cognition;informant;Intervention;Interview;Knowledge;Language;Life Cycle Stages;Life Experience;life span;longitudinal design;Longitudinal Studies;Massachusetts;Mental Depression;Mental Health;Mental health promotion;Methods;Modeling;National Institute on Minority Health and Health Disparities;Nepal;older adult;Outcome;Participant;Pennsylvania;Personal Satisfaction;physical conditioning;Population;Post-Traumatic Stress Disorders;protective factors;Provider;psychosocial;Psychosocial Assessment and Care;psychosocial wellbeing;Qualitative Methods;racial minority population;Reduce health disparities;Refugee Camp;Refugees;Research;Research Design;Research Personnel;research study;Risk Factors;Role;social culture;Social isolation;Social support;Stress;stressor;Subgroup;Symptoms;therapy design;Time;Torture;Trauma;United States;Vulnerable Populations;War;Work

PROJECT_TITLE: The Impact of Forced Displacement on Aging Adult Mental Health: Implications for Developing Interventions

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (M1)]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Inflammation in early life has been linked to prematurity-related chronic respiratory disease such as bron- chopulmonary dysplasia, but the innate immune mechanisms behind this are poorly understood. The goal of this proposal is to determine the mechanisms by which inflammatory stress in early life induces NKG2D lig- ands on target cells and activates NKG2D-expressing lung lymphocytes (gamma delta T cells and NK cells), and how this, in turn, induces cytotoxicity and impairs alveolar and vascular development. These studies have the potential to uncover new therapeutic targets for prematurity-related chronic lung disease and to reveal how inflammation at critical time points impairs lung development and functioning.

PI_NAMEs: POPOVA, ANTONIA PETROVA (contact)

PROGRAM_OFFICER_NAME: NATARAJAN, ARUNA R

PROJECT_TERMS: Activated Lymphocyte;Activated Natural Killer Cell;Adoptive Cell Transfers;airway epithelium;Alveolar;antibody transfer;Apoptosis;aspirate;Attenuated;Binding;Binding Proteins;Biological Assay;Blood Vessels;Bronchopulmonary Dysplasia;C-Type Lectins;Cd68;Cell Death;Cell Proliferation;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cellular Stress;Characteristics;Chronic;Chronic lung disease;chronic respiratory disease;curative treatments;cytokine;cytotoxic;cytotoxicity;D Cells;Development;early life exposure;Endotoxins;Epithelial Cells;Expenditure;experimental study;Exposure to;Fetal Lung;Flow Cytometry;Gene Expression Profile;Goals;Granzyme;Growth;Healthcare;Human;Hyperoxia;IL17 gene;Immune;immunogenicity;immunopathology;Impairment;In Vitro;Infant respiratory distress;Inflammation;Inflammation Mediators;Inflammatory;innate immune mechanisms;intraamniotic infection;Life;Ligands;Link;Lipopolysaccharides;Lung;lung development;Lung Diseases;lung preservation;Lymphocyte;Macrophage;Maps;Mechanical ventilation;member;Messenger RNA;MHC Class I Genes;Modeling;Morbidity - disease rate;mouse model;Mus;Natural Killer Cells;Natural Source;Neonatal;Neonatal Hyperoxic Injury;Neonatal lung;neutralizing antibody;new therapeutic target;novel;Pathogenesis;Pathway interactions;Population;premature;Premature Infant;preservation;Preventive treatment;Production;Proliferating;Proteins;pulmonary function;Pulmonary Inflammation;receptor;regeneration potential;Regulation;Research Support;response;Risk;Role;Sampling;Sepsis;Signal Transduction;Stress;Testing;therapeutic target;Time;Trachea;Transcript;Tretinoin;γδ T cells

PROJECT_TITLE: Regulation of Neonatal Lung Inflammation by Novel Innate Immune Mechanisms

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Precision Medicine

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Cancer remains to be a leading cause of death worldwide despite recent advancements made in therapeutics and treatment modalities, which include immunotherapies. The NCI-funded research program of Unit Director Dr. Timothy Chan seeks to further identify the molecular and genomic drivers of immunotherapy efficacy in cancer patients to which I am a singularly essential driver of all computational efforts. The Research Specialist Award will provide crucial support, allowing me to continue my essential work in NCI-funded research projects and to sharpen my expertise in bioinformatics to advance the fields of immunogenomics and precision oncology.

PI_NAMEs: MAKAROV, VLADIMIR  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Address;Algorithms;Award;Bioinformatics;Cancer Patient;career;Cause of Death;Clinic;Clinical;Communities;Computational Biology;Computer Analysis;computer framework;Data Set;Educational workshop;experience;Fostering;Funding;Genomics;Goals;Immunogenomics;Immunotherapy;improved;knowledge base;Laboratories;Malignant Neoplasms;Medical;Melanoma;Microsatellite Instability;Modality;Molecular;Mutation;Neoplasm Metastasis;next generation sequencing;Non-Small-Cell Lung Carcinoma;Oncology;Patients;pembrolizumab;precision oncology;programs;Publications;Research;Research Project Grants;Research Support;Role;Science;Scientist;skills;Specialist;symposium;Talents;Technology;Therapeutic;tool;tumor;Tumor Immunity;Unresectable;Work

PROJECT_TITLE: Immunogenomics platform for the analysis of cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (M2)]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Immunotherapy;Kidney Disease;Orphan Drug;Rare Diseases;Sickle Cell Disease

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative The three-dimensional chromatin architecture of mammalian cells, particularly within T cells affected by the tumor immune microenvironment, remains a critical yet underexplored factor in understanding the aggressive renal medullary carcinoma (RMC), which largely impacts young African descendants with sickle cell disease (SCD). Using the Hi-C technique, our team, led by experts including Dr. Liuqing Yang and Dr. Wenbo Li, has observed significant genomic structural changes in CD8+ T cells from SCD patients, suggesting a potential link between altered chromatin structures in CD8+ T cells and RMC's immune resistance, with ferroptosis playing a central role. We anticipate that our findings will guide the next decade of treatment development, positioning ICI and CAR T-cell therapies as leading RMC treatments, and underpin early-phase clinical studies led by Dr. Pavlos Msaouel to further refine these therapeutic approaches.

PI_NAMEs: LI, WENBO ;MSAOUEL, PAVLOS ;YANG, LIUQING  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;African;African ancestry;Ammonium;Animal Model;ANK2 gene;Antioxidants;Antitumor Response;Apoptosis;Architecture;Automobile Driving;Biological Process;Biology;Cancer Biology;cancer type;CAR T cell therapy;CD8-Positive T-Lymphocytes;Cells;Chromatin;Chromatin Loop;chromatin modification;Chromatin Structure;Chromatin Structure Alteration;chromosome conformation capture;Citrates;Clinical;Clinical Research;Collaborations;Collecting Ducts of Bellini Carcinoma;Communities;Cystine;Data;Development;Disease;disease model;Engraftment;Environment;Exhibits;Genetic Transcription;Genome;Genomics;Glutathione;Goals;Growth;Hemoglobinopathies;Hereditary Disease;Human;human disease;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;immune resistance;immunodeficiency;Immunotherapy;improved;improved outcome;Individual;individualized medicine;Infiltration;inhibitor;innovation;insight;Interdisciplinary Study;Investigation;Iron;kidney medulla;Knowledge;Link;Malignant Neoplasms;Mammalian Cell;Mammals;Maps;Modeling;Modification;Molecular;Mus;next generation;Outcome;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;Peripheral Blood Mononuclear Cell;pharmacologic;Phase;Pilot Projects;Play;Positioning Attribute;Process;Prognosis;prognostic;Renal Carcinoma;Research;Resistance;resistance mechanism;Risk;Role;Sickle Cell;Sickle Cell Anemia;Sickle Cell Trait;sickling;SMARCB1 gene;Source;standard care;stem;Structure;synergism;T cell therapy;T-Lymphocyte;targeted cancer therapy;Techniques;Therapeutic;therapy development;translational pipeline;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;tumorigenesis;Work

PROJECT_TITLE: Elucidating T Cell Ferroptosis in Renal Medullary Carcinoma: 3D Genome Architecture Rewiring and Therapeutic Alleviation

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative In alignment with the requirements of this funding opportunity announcement, our research proposal will establish robust sample collection, processing, and storage protocols that preserve the integrity of the pools of NAD+, NADH, NADP, NADPH (and related metabolites); optimized LC/MS methods for measuring NAD+, and related metabolites; and commutable standards and procedures for harmonizing assays across laboratories. The validated sample collection and storage procedures, and NADome Quant assay will be used to make simultaneous measurements of NAD+ and related metabolites in human tissues, whole blood, and PBMCs harvested in the setting of a clinical trial of an NAD+ precursor, nicotinamide mononucleotide, in patients scheduled for elective coronary artery bypass graft surgery. We will conduct a proof-of-concept randomized controlled trial to determine whether oral NMN administration is more efficacious than placebo in raising myocardial NAD+ levels and reducing myocardial injury during CABG surgery.

PI_NAMEs: BHASIN, SHALENDER  (contact);GARDELL, STEPHEN JAMES;LEAF, DAVID EVAN

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: Acids;Acute Renal Failure with Renal Papillary Necrosis;Address;Adult;Aging;American;Animal Model;Aorta;Attenuated;Biological Assay;Biopsy;Biopsy Specimen;Calibration;Cardiac;Cells;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical Research;Clinical Trials;cofactor;Collaborations;Collection;college;Controlled Clinical Trials;Coronary Artery Bypass;Custom;Data;design;Development;Disease;Dose;Double-Blind Method;double-blind placebo controlled trial;efficacy trial;Endothelium;Fatty acid glycerol esters;Funding Opportunities;Glycosylated hemoglobin A;Harvest;Heart Injuries;High Pressure Liquid Chromatography;Human;human study;human tissue;Hydrolase;Injury;interest;Ischemia;Kidney;Laboratories;Leg;Link;Liquid Chromatography;liquid chromatography mass spectrometry;Measurement;Measures;Methodology;Methods;Modeling;Muscle;Myocardial;myocardial injury;Myocardium;NADH;NADP;Nicotinamide adenine dinucleotide;Nicotinamide Mononucleotide;Operative Surgical Procedures;Oral;Oral Administration;Oxidation-Reduction;Pathologist;Patient Schedules;Patients;Perchloric Acids;Peripheral Blood Mononuclear Cell;Phase;Placebo Control;Placebos;Play;Poly(ADP-ribose) Polymerases;Postoperative Period;preclinical study;preservation;prevent;Procedures;Process;Protocols documentation;pyridine nucleotide;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Reference Standards;Regimen;Reperfusion Injury;Research Proposals;Role;sample collection;Sampling;Sirtuins;Skin;Specificity;Specimen;Stable Isotope Labeling;Standardization;subcutaneous;tandem mass spectrometry;Testing;Therapeutic;Tissue Harvesting;Trichloroacetic Acid;Validation;Variant;Whole Blood

PROJECT_TITLE: Development, Validation, and Harmonization of Methods for Collection and Measurement of NAD+ and Related Metabolites: Application to a Randomized Trial of Patients Undergoing Coronary Artery Bypass

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-2 (M1)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Neurostimulation is a promising method for treating emotion dysregulation, a symptom that contributes to transdiagnostic psychiatric distress and is associated with insula dysfunction. Given that the neurostimulation efficacy is related to the precision of stimulation at a specific cortical target, understanding the neural mechanisms of emotion dysregulation will lead to improved transdiagnostic brain stimulation interventions. With the goal of optimizing therapeutic neuromodulation, proposed studies will investigate the role of insular resting-state and task-related functional network connectivity in transdiagnostic emotion dysregulation and brain stimulation therapy for dysregulation.

PI_NAMEs: NEACSIU, ANDRADA DELIA (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Adult;Affect;Amygdaloid structure;Arousal;Autobiography;Brain;career;causal model;Clinical;cognitive control;cognitive enhancement;cognitive reappraisal;Communities;comparison group;Complex;Coupling;Cues;Data;Data Collection;Development;Diagnostic;Distress;emotion dysregulation;emotion regulation;Emotional;Emotions;Equilibrium;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Galvanic Skin Response;Goals;graduate student;Heart Rate;Hyperactivity;improved;improved outcome;independent component analysis;Individual;Individual Differences;Informal Social Control;Insula of Reil;Intervention;Lateral;Learning;Linear Models;Magnetic Resonance Imaging;Maintenance;Maps;Measures;Medial;Memory;Mental disorders;Methods;Modeling;negative affect;Network-based;neural circuit;neural network;neuroimaging;neuromechanism;neuroregulation;Neurosciences;novel;Parents;Participant;Patient Self-Report;Pattern;personalized therapeutic;Physicians;Physiological;Pilot Projects;post intervention;Process;Psychiatry;Psychopathology;recruit;Regulation;response;Rest;Risk Factors;Role;Scientist;Severities;Signal Transduction;skills;Stimulus;success;Symptoms;Testing;Therapeutic;therapy development;Training;Training Support;Treatment Efficacy;treatment response;Underrepresented Students

PROJECT_TITLE: Neurostimulation Enhanced Cognitive Restructuring for Transdiagnostic Emotional Dysregulation: A Component Analysis

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Radiation Oncology

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Optimization of strategies to improve NCI-sponsored clinical trial participation throughout the Weill Cornell Medicine - Meyer Cancer Center Sphere Narrative: The applicant Dr. Tagawa is MCC's PI for the Alliance, heavily involved in the GU committee, and serves on the NCI Prostate Cancer Task Force. He has personally led and mentored others in leading NCI studies, is a top NCTN accrual leader, and will continue to expand the MCC NCI trial portfolio into Brooklyn and Queens.

PI_NAMEs: TAGAWA, SCOTT T (contact)

PROGRAM_OFFICER_NAME: MAHER, MOLLY ELIZABETH

PROJECT_TERMS: Advisory Committees;American College of Radiology Imaging Network;Cancer and Leukemia Group B;cancer care;Cancer Center;cancer clinical trial;Cancer Therapy Evaluation Program;Catchment Area;Clinical Research;Clinical Trials;Discipline;Disease Management;Early Therapeutic-Clinical Trials Network;Eastern Cooperative Oncology Group;experience;Flushing;Funding;Hospitals;improved;Infrastructure;Institution;Investigational Therapies;Leadership;Location;Malignant neoplasm of prostate;Medical center;Medicine;member;Mentors;Methodist Church;Minority;New York;Ohio;Oncology;Patients;Population Heterogeneity;Presbyterian Church;Process;programs;Radiation Oncologist;Radiation Therapy Oncology Group;Research;Research Personnel;Role;Scientist;Side;Site;Specialist;Underserved Population;Universities;virtual;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (M1)]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: SHAWNEE

ORG_NAME: ABSENTEE SHAWNEE TRIBE OF OKLAHOMA

ORG_STATE: OK

PI_NAMEs: NAEL, SIAVASH ;PATERNITE, HADYN KERNAL (contact)

PROGRAM_OFFICER_NAME: OUDEKERK, BARBARA ANN

PROJECT_TERMS: Acute Pain;Address;Administrator;Affect;Alaska Native;Applications Grants;Architecture;Area;authority;Awareness;behavioral health;Behavioral Medicine;Bypass;care coordination;care seeking;Caring;chronic pain;Clinical;Clinical assessments;clinical care;Clinical Research;Communities;Community Health;Community Healthcare;Community Services;Complex;Continuity of Patient Care;Custom;Data;data sharing;Databases;design;Development;Diagnosis;Educational Curriculum;Effectiveness;Environment;Epidemic;Evaluation;experience;Family;Feedback;Focus Groups;Funding;Goals;Grant;Guidelines;Health;health care delivery;Health system;Healthcare;Healthcare Systems;Helping to End Addiction Long-term;improved;indigenous community;Individual;insight;Intention;interest;Intervention;Interview;Investments;Legal;Managed Care;Maps;Medical;Medical History;member;Mental Health;Modeling;Native American community;Native American population;Native Americans;neighborhood safety;Oklahoma;Opiate Addiction;opioid misuse;opioid use disorder;Overdose;Pain;Pain management;Pathway interactions;Pharmacists;Phase;Physicians;Privacy;Probability;Procedures;Process;programs;Progress Reports;Protocol Compliance;protocol development;Protocols documentation;Psychologist;Quality of Care;Questionnaires;Recording of previous events;Recreation;Research;Resources;Role;Schedule;Site;social;Social Work;socioeconomics;Speed;stimulant use disorder;Substance abuse problem;substance use;System;Systems Analysis;Testing;Thinking;tool;treatment services;tribal community;tribal health;tribal member;tribal Nation;Tribes;United States National Institutes of Health;Weight;Wellness Program

PROJECT_TITLE: Absentee Shawnee Tribal Health System: HEAL Initiative: Native Collective Research Effort to Enhance Wellness (N CREW) Program- Addressing Overdose, Substance Use, Mental Health, and Pain (OT2)

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 OTHR-6 (01)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Nutrition;Primary Health Care;Social Determinants of Health

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: This project will test the effect of a home delivered foods and kitchen skills (FoRKS) intervention among adult safety-net primary care patients who report food insecurity and have hypertension. Sixteen and 24-week blood pressure will be compared between participants randomized to FoRKS vs enhanced usual care. Additional outcomes include learning engagement, kitchen confidence and skills, and nutrition and food security.

PI_NAMEs: CLARK, DANIEL O (contact);HOLDEN, RICHARD J

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;Adult;aged;Behavioral Mechanisms;Blood Pressure;Carbohydrates;Chronic Disease;Consent;cooking;cost effective;cost effectiveness;delivered meals;Dietitian;Drug Prescriptions;Education;Engineering;Enrollment;experience;Food;food insecurity;food resource;food security;Glycosylated hemoglobin A;Home;Hypertension;implementation intervention;Intervention;Knowledge;Learning;learning engagement;Maintenance;Medical;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;nutrition education;Nutritional;Outcome;parent project;Participant;post intervention;primary care patient;programs;Randomized;Randomized, Controlled Trials;Reporting;safety net;satisfaction;screening;Self Efficacy;Self Management;simulation;skills;social;social health determinants;Social support;Sodium;System;Testing;tool;treatment as usual;United Nations;user centered design;videoconference

PROJECT_TITLE: Preparing a Food Insecurity Intervention for Implementation

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Hypertension;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: Environmental factors associated with social determinants of health associate with dementia after brain bleeds, and modifiable changes to the genome, called epigenetic signals, might mediate that association. We will investigate epigenetic signals and their association with both social determinants of health and dementia outcomes in 607 White, Black, Hispanic, and Asian survivors of brain bleeds who are already being enrolled in an existing separate NIH clinical study. In this new study, we will determine which epigenetic changes causally mediate the relationship between environmental exposures and dementia, in order to help identify biological pathways that can be modified by drugs or behavioral interventions to reduce health disparities in dementia after brain bleeds.

PI_NAMEs: ANDERSON, CHRISTOPHER DAVID (contact);ROSAND, JONATHAN

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Address;adverse outcome;Air Pollution;Asian;Award;Behavior;Behavior Therapy;Behavioral;Biological;Biological Response Modifier Therapy;Black race;Blood Pressure;blood pressure reduction;blood treatment;Blood Vessels;Brain;Cardiovascular Diseases;Caring;causal variant;Cerebral hemisphere hemorrhage;Cerebral small vessel disease;Clinical Research;Cognitive;cohort;Collection;cost;Data;Dementia;design;Detection;Development;Disease Progression;disparity reduction;DNA;DNA Methylation;Enrollment;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Epigenetic Process;epigenome;Ethnic Origin;Etiology;Exposure to;Funding;Genetic;Genome;genome annotation;genome-wide;Genomics;Genotype;Goals;Health;health disparity;health disparity populations;health equity promotion;Hemorrhage;high risk;Hispanic;Hypertension;hypertensive;Impaired cognition;improved;Individual;Infrastructure;Intervention;Investments;Knowledge;Link;marginalized population;Mediating;Mediation;Mediator;Mendelian randomization;Mental Depression;MicroRNAs;modifiable risk;multidisciplinary;National Institute of Neurological Disorders and Stroke;novel;Outcome;Parents;Participant;Pathway interactions;Pharmaceutical Preparations;Population;post stroke;prevent;Prevention;programs;Race;Recurrence;Reduce health disparities;Resources;Risk;Risk Factors;Risk Reduction;Role;Signal Transduction;small molecule;social health determinants;sociodemographics;Stroke;success;Survivors;Testing;therapeutic development;therapy resistant;Time;tool;treatment response;United States National Institutes of Health;Variant;vascular cognitive impairment and dementia

PROJECT_TITLE: REACH-EpiVCID

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-K (55)]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE Experiences with early childhood adversity can disrupt the typical development of a child and are associated with unfavorable educational results, such as low standardized reading scores. With over half of the United States population reporting at least one adverse event in their lifetime, this study examines how adverse experiences affect several cognitive processes that facilitate planning actions, solving problems, and staying engaged on reading tasks among children exposed to adversity. By identifying the specific cognitive processes influenced by adversity, this study aims to provide valuable insights into how negative life experiences affect a consequential educational outcome (i.e., reading) that has important lifelong implications to inform future research, theory, and classroom practices.

PI_NAMEs: ALVARADO, CHARLES  (contact)

PROGRAM_OFFICER_NAME: MASH, CLAY

PROJECT_TERMS: acute stress;Address;Adolescence;adverse childhood events;Adverse event;Affect;Attenuated;Behavior;Benchmarking;biological adaptation to stress;Child;Child Health;Child Rearing;Chronic stress;Cognitive;cognitive ability;cognitive load;cognitive process;Communities;Complex;Data;Data Set;deprivation;Development;Developmental Process;Dimensions;early adolescence;early childhood;early life adversity;Education;eighth grade;Environment;Equation;Equipment and supply inventories;executive function;experience;Exposure to;flexibility;Foundations;fourth grade;Future;Goals;grasp;Health;Heterogeneity;high risk population;Home;indexing;insight;Intervention;Intervention Studies;Knowledge;Language;Learning;Life;Life Experience;Linguistics;Measurable;Measurement;metacognition;Methods;middle childhood;Modeling;Modernization;Monitor;Neurocognitive;Oral;Outcome;Outcome Measure;Pathway interactions;person centered;Play;Population;Problem Solving;Process;programs;Reader;Reading;reading ability;reading comprehension;recruit;Reporting;Research;Research Personnel;Research Support;Risk;Role;School-Age Population;Schools;Science;Scientist;Short-Term Memory;skills;Sorting;Standardization;Statistical Models;Students;Surveys;teacher;Testing;Text;theories;therapy development;Time;Training;Trauma;United States;Vocabulary;Work

PROJECT_TITLE: Identifying neurocognitive correlates of reading impacted by adversity exposure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-F (50)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: AUGUSTA

ORG_DEPT: NEUROLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Preclinical research suggests that head trauma to an individual with a genetic predisposition for Alzheimer's disease (AD) likely leads to an earlier age of AD onset. However, the underlying mechanism and preventative or post-treatment strategies are lacking. This proposal meets this critical need as it will examine the potential mechanisms of asymptomatic brain injury-accelerated AD dementia, and evaluate the therapeutic efficacy of a promising and important non-invasive laser treatment strategy.

PI_NAMEs: ZHANG, QUANGUANG  (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: abeta accumulation;Acceleration;Aftercare;Age;Age of Onset;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Behavioral;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier function;Brain;brain endothelial cell;Brain Injuries;Cause of Death;Cell Aging;Cell Physiology;cerebrovascular;Cerebrovascular Disorders;clinically relevant;Closed head injuries;Cognitive;cognitive function;Craniocerebral Trauma;Cystathionine beta-Synthase;Dementia;dementia risk;disability;Disease Progression;DNA;DNA Damage;Drops;efficacy evaluation;Endothelial Cells;Endothelium;Enzymes;Epidemic;Event;experimental study;Extravasation;functional improvement;Genetic Predisposition to Disease;improved;In Vitro;in vivo;Individual;innovation;innovative technologies;insight;Investigation;Ions;Lasers;Life;Link;Low-Level Laser Therapy;Mediating;Meta-Analysis;mild traumatic brain injury;Modeling;Neurons;neurovascular;neurovascular coupling;novel;Onset of illness;Pathogenesis;Pathologic;Pathway interactions;Patients;Penetration;Pharmaceutical Preparations;Photons;Physiologic pulse;Play;pre-clinical research;preservation;prevent;Preventive treatment;Process;protective effect;Public Health;Rattus;repaired;Research;response;Role;senescence;senolytics;Severities;Signal Transduction;Signaling Molecule;System;Testing;Therapeutic;therapy development;Time;Transgenic Organisms;Traumatic Brain Injury;Treatment Efficacy;treatment strategy;United States;Weight

PROJECT_TITLE: Pulsed laser therapy in an asymptomatic head injury-accelerated Alzheimer's model

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative The shortening of telomeres is a primary barrier to tumorigenesis that is bypassed by the reactivation of telomerase in cancer cells. To gain deeper insights into the telomere tumor suppressor pathway, this project is focused on understanding how telomeres are replicated with particular emphasis on the role of CST–Polα- primase in telomere maintenance and telomere length control. The experiments will contribute fundamental knowledge on telomere maintenance and the role of telomeres in cancer.

PI_NAMEs: TAKAI, HIROYUKI  (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Binding;Birth;Bypass;cancer cell;cancer predisposition;career;Cell Compartmentation;Cell Cycle Arrest;Cells;Coats plus syndrome;Collaborations;Companions;Complex;Creativeness;Cryoelectron Microscopy;Data;disabled;DNA;DNA biosynthesis;DNA Primase;Dyskeratosis Congenita;experimental study;Goals;graduate student;Human;In Vitro;in vivo;innovation;insight;Knowledge;Length;Malignant Neoplasms;Mediating;member;Multiple Organ Failure;new technology;Pathway interactions;Phosphorylation;Phosphotransferases;Play;prevent;programs;Proliferating;Protein Dephosphorylation;recruit;Regulation;Research;response;Role;Single-Stranded DNA;skills;stem cells;Structure;success;Syndrome;Telomerase;telomere;telomere loss;Telomere Maintenance;Telomere Shortening;Tumor Suppressor Proteins;tumorigenesis

PROJECT_TITLE: The interplay of the CST complex and telomerase at human telomeres


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PHR: Narrative Human major histocompatibility complex (MHC) class I proteins, also called human leukocyte antigens (HLA) class I, are highly variable in human populations. The specific variants that are expressed in people are determinants of life and death in untreated disease, by governing the efficacy of the immune response. This proposal will study how HLA class I variants differ in their functional properties, to better understand why different people respond differently to the same disease.

PI_NAMEs: RAGHAVAN, MALINI  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Affect;Affinity;Antigen Presentation;Antigen-Presenting Cells;antigenic peptide transporter;Antigens;Binding;Binding Sites;CD8-Positive T-Lymphocytes;Cell surface;Cells;Cessation of life;Characteristics;Communicable Diseases;Competence;Complex;Cross Presentation;Cytosol;Dendritic Cells;Dependence;Development;Disease;Disease Outcome;Endoplasmic Reticulum;Endosomes;Ensure;Equilibrium;Future;Genes;Genetic Polymorphism;genomic locus;Globulins;glycosylation;Histocompatibility;Histocompatibility Antigens Class I;Histocompatibility Antigens Class II;HLA Antigens;Human;human disease;Immune;Immune response;Immunity;Immunologic Surveillance;immunological intervention;Immunotherapeutic agent;Individual;Inflammatory;Knowledge;Life;Light;Maintenance;Major Histocompatibility Complex;Malignant Neoplasms;Mannose;Mediating;MHC Class I Genes;Natural Killer Cells;neoantigens;novel;Nutritional;pathogen;Pathogenicity;Pathway interactions;peptide I;Peptides;Persons;Play;Polysaccharides;Population;preference;Prevalence;Process;Property;Proteins;receptor;resilience;response;Role;Somatic Mutation;Stress;Surface;T cell response;T-Cell Receptor;T-Lymphocyte;tapasin;Textbooks;Therapeutic;tool;Variant

PROJECT_TITLE: Influences of HLA Class I Polymorphisms on immune responses

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rural Health;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative: In traumatic brain injury intracranial pressure (ICP) needs to be monitored to prevent secondary injury. Unfortunately, ICP is currently measured invasively and because of the complexity and risks of the procedure it is limited to most critically ill patients. We propose to develop a novel low-cost and high performances portable diffuse optical device able to accurately monitor ICP continuously and non-invasively. The ability to monitor ICP non-invasively would allow to extend monitoring past the critical condition, and monitor patients in ambulatory and emergency settings, allowing for faster and more effective triage of trauma patients.

PI_NAMEs: FRANCESCHINI, MARIA ANGELA  (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: 3-Dimensional;Accounting;Acute;Adopted;Adoption;Algorithms;Bilateral;Biological Markers;Blood flow;Blood Pressure;Blood Volume;Brain;brain health;Brain Injuries;Cardiac;Caring;Cause of Death;cerebral autoregulation;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Clinical;clinical practice;Clinical Research;clinical translation;Coma;commercialization;Computer software;cost;cranium;Critical Illness;design;Detection;detector;Devices;Diffuse;disability;emergency settings;Fiber;Future;Guidelines;Health Status;Hemoglobin;heterodyning;high risk;Hospitalization;Image;improved;improved outcome;indexing;Infection;Injury;injury-related death;instrument;Intervention;Intracranial Hemorrhages;Intracranial Pressure;Knowledge;Lasers;Light;light weight;Magnetic Resonance Imaging;Measurement;Measures;miniaturize;Minority;Monitor;Monte Carlo Method;Morphology;Near-Infrared Spectroscopy;Neurologic;neurovascular;Noise;non-invasive monitor;novel;operation;Optical Methods;Optics;Outcome;Oxygen Consumption;Patient Monitoring;Patients;Performance;Perfusion;personalized medicine;Persons;Photons;Photoplethysmography;Physiologic pulse;Pilot Projects;portability;predictive modeling;pressure;prevent;Procedures;prototype;Publications;Pulsatile Flow;Recommendation;Resistance;Resources;Risk;Role;rural area;rural dwellers;rural setting;Sampling;Scalp structure;sensor;Signal Transduction;Skin;Source;Spectrum Analysis;standard of care;System;TBI Patients;Technology;Testing;Time;Transcranial Doppler Ultrasonography;Trauma patient;Traumatic Brain Injury;Triage;United States;Venous;Veterans;Vulnerable Populations;wearable device;Work

PROJECT_TITLE: Low-cost high-performance NIRS-SCOS device for non-invasive monitoring of cerebral blood flow and intracranial pressure in traumatic brain injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative: The UC Davis REsearch to Advance Connected and Community Health Equity (ReACH Equity) Predoctoral Training Program Plan The UC Davis ReACH Equity predoctoral training program will leverage UC Davis’s strengths in nursing, social, behavioral, and biomedical sciences, its proximity to the CA state legislature, the varied historically and presently marginalized communities (HMCs) it serves, and the robust community partnerships it has developed over time to provide a rich training environment for a diverse group of 26 trainees to solve the nation’s pressing health problems and persistent health challenges. Through direct instruction, experiential learning, and mentored research, trainees will gain knowledge and skills that will prepare them for future research careers in academia, public policy, and industry aimed at ensuring advances in equity-focused prevention science and population health are utilized among HMCs. Continuous evaluation of our program will affirm that we accomplish the aims of this training program and successfully train the next generation of health equity researchers.

PI_NAMEs: LYLES, COURTNEY REES;SIMMONS, LEIGH ANN  (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Community Health;connected health;health equity;Research

PROJECT_TITLE: Research to Advance Connected and Community Health Equity (ReACH Equity)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-N (51)]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: PROJECT NARRATIVE Mycobacterium tuberculosis population heterogeneity, including persister cell formation, can prevent effective therapeutic treatment, resulting in extensive treatment duration and recurrent tuberculosis infection. Triggered persister formation in response to environmental stress may be facilitated through DNA methylation of the M. tuberculosis genome. We aim to demonstrate a role for DNA methylation in the M. tuberculosis stress response and in promoting population heterogeneity, including the formation of a persister sub-population.

PI_NAMEs: KRIEL, NASTASSJA LISE (contact)

PROGRAM_OFFICER_NAME: JESSUP, CHRISTINE

PROJECT_TERMS: acid stress;Acinetobacter baumannii;Address;Aftercare;Antibiotic Resistance;antibiotic tolerance;Antibiotics;Antitubercular Agents;Award;Bacillus;Bacteria;Bioinformatics;biological adaptation to stress;Biological Assay;biomarker identification;career development;Career Mobility;Cells;cellular imaging;Cellular Morphology;Cessation of life;chemotherapy;co-infection;Colorado;Computer Models;Country;CRISPR interference;Data;Data Analyses;Development;Diagnosis;Disease;DNA;DNA Methylation;DNA methylation profiling;Drug resistance;drug resistance development;Environment;Epigenetic Process;epigenetic regulation;Escherichia coli;experience;Flow Cytometry;Fluorescence-Activated Cell Sorting;Foundations;Funding;Future;Gene Expression;Genes;genome sequencing;global health;Goals;Heritability;Heterogeneity;HIV/AIDS;Hypoxia;Image;Image Analysis;imaging platform;Immunologist;Infection;insight;interdisciplinary collaboration;Investigation;live cell imaging;low and middle-income countries;M. tuberculosis genome;Macrophage;Mentors;Mentorship;Methylation;Methyltransferase;Microfluidics;Minimum Inhibitory Concentration measurement;Modeling;multidisciplinary;mutant;Mutation;mycobacterial;Mycobacterium tuberculosis;Notification;overexpression;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Plasmids;Population;Population Heterogeneity;Predisposition;prevent;Prevention;protein expression;Proteins;Proteome;Proteomics;Protocols documentation;Recurrence;Regulation;Reporter;Reporting;Research;Research Personnel;Resistance;resistance mutation;response;Role;Scientist;South Africa;Staphylococcus aureus;Starvation;Sterilization;Stress;Technical Expertise;Testing;therapeutically effective;Time;Training;treatment duration;Treatment Efficacy;Treatment Failure;treatment risk;Tuberculosis;tuberculosis treatment;Universities

PROJECT_TITLE: Mycobacterial Epigenetics: Investigating the impact of DNA methylation on antibiotic tolerance and persistence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICP-P (55)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;Contraception/Reproduction;Genetics;Infertility;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_DEPT: GENETICS

PHR: Project Narrative The proposed studies will provide basic knowledge of the molecular, cellular, and developmental mechanisms of uterus formation and the gene expression mechanisms that mediate the hormone pathway for the elimination of female reproductive tract organ progenitor tissues during male differentiation. These studies should provide new insights into the causes of uterine variation and sex development.

PI_NAMEs: BEHRINGER, RICHARD R (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Biology;Competence;Complex;Defect;Development;Disease;Ductal Epithelium;Embryo;Epididymis;Epithelium;Etiology;experimental study;Female;female reproductive tract;fetal;Fetal Kidney;Gene Expression;Genes;Genetic Transcription;Gonadal Hormones;High-Risk Pregnancy;hormonal signals;Hormone Responsive;Hormones;Horns;Human;Infertility;insight;Knowledge;Lead;male;malformation;Malignant Neoplasms;Mammalian Oviducts;Mammals;Mediating;Mesenchymal Stem Cells;Mesenchyme;migration;Molecular;Morphogenesis;Morphology;mullerian-inhibiting hormone;Mus;Organ;organ growth;Ovary;Pathway interactions;Phenotype;Process;Protein Secretion;receptor binding;Regulatory Element;Reporter Genes;Reproduction;reproductive organ;reproductive tract;Seminal Vesicles;sex;sex development disorder;Sexual Development;Signaling Protein;Site;Spontaneous abortion;Structure of mesonephric duct;Structure of paramesonephric duct;System;Testis;Testosterone;tissue stem cells;Tumor Suppressor Genes;Urogenital Sinus;Uterus;Vagina;Variant;Vas deferens structure;WNT7A gene;WT1 gene

PROJECT_TITLE: Reproductive tract organ development and differentiation

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Aging;Clinical Research;Emergency Care;Health Services;Patient Safety

ORG_CITY: CHAPEL HILL

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Aspirin is one of the most used drugs in the world and is associated with increased risk of bleeding. Deprescribing (or the supervised process of stopping) aspirin may be beneficial for many older adults. We plan to conduct foundational research, guided by Intervention Mapping Theory, to inform the development of a novel emergency department-based deprescribing intervention to address inappropriate aspirin use among older adults presenting with bleeding.

PI_NAMEs: CASEY, MARTIN FRANCIS (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Accident and Emergency department;Address;Adverse drug event;Aging;Anemia;Appointment;Aspirin;Behavior;Benefits and Risks;Cardiology;Cardiovascular Diseases;cardiovascular disorder prevention;career;Caring;Chronic;chronic care model;cohort;Consumption;Counseling;Data;Decision Making;Delirium;design;Development;Diagnosis;Doctor of Philosophy;Dose;Drug Interactions;Drug usage;Elderly;Emergency Care;Emergency Department Physician;Emergency department visit;Emergency Department-based Intervention;Emergency Medicine;Epidemiology;Event;Failure;falls;follow-up;Foundations;Frequencies;Future;Geriatrics;Goals;health care settings;Hemorrhage;Home;Intervention;intervention mapping;Interview;Medical;medical specialties;Mentorship;Modeling;Myocardial Infarction;novel;Observational Study;older adult;Opioid;Outpatients;participant enrollment;Patients;Pharmaceutical Preparations;Physicians;Prevention;Primary Care;Primary Prevention;Process;prospective;Provider;provider factors;Recommendation;Recording of previous events;Recurrence;Reporting;Research;Risk;Sampling;Stroke;theories;Work

PROJECT_TITLE: Developing a foundation for a novel emergency department-based intervention to address inappropriate aspirin

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-R (M1)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: Columbus

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

PHR: OVERALL PROJECT NARRATIVE The ultimate goal of this P01 Program Project Grant (PPG) competitive renewal application is to utilize the HTLV-1 T-cell immortalization model to gain understanding of the microenvironmental, cellular and viral factors that lead to progression to leukemia, and with this knowledge, to identify unique targets for diagnosis and treatment of HTLV-1 infection and ATL and related leukemia/lymphoma.

PI_NAMEs: GREEN, PATRICK LEE (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: adult T-cell leukemia cell;Adult T-Cell Leukemia/Lymphoma;Animals;anti-cancer research;Area;Binding Proteins;Binding Sites;Biological;Biometry;cancer cell;Cancer Model;cancer therapy;CCCTC-binding factor;CD4 Positive T Lymphocytes;cell immortalization;Cells;Diagnosis;Disease;Disease Progression;Disseminated Malignant Neoplasm;DNA Sequence Alteration;Event;Functional disorder;Funding;Goals;Grant;Human;Human T-lymphotropic virus 1;improved;Infection;Knowledge;leukemia;leukemia/lymphoma;leukemogenesis;Lymphocyte Activation;Lymphoma;Lymphoproliferative Disorders;Malignant - descriptor;Malignant Neoplasms;Messenger RNA;Modeling;neoplastic;new therapeutic target;novel therapeutics;Osteolytic;Outcome;Pathogenesis;Pattern;Play;Positioning Attribute;preneoplastic cell;Program Research Project Grants;programs;Proteins;Provirus Integration;response;Retroviridae;Retroviridae Infections;Role;Syndrome;T-Lymphocyte;Viral;Viral Vector;Virus;Virus Diseases;Virus Latency;Work;Zinc Fingers

PROJECT_TITLE: Retrovirus Models of Cancer


ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative The unifying postulate of this competitive renewal P01 proposal is that comparative studies of KSHV, EBV, and MHV68 will continue to accelerate the discovery of pathways regulated by non-coding RNAs (ncRNAs). Our findings over the last 4 years indicate that both short and long ncRNAs contribute to γ-herpesvirus latency and tumorigenesis.

PI_NAMEs: RENNE, ROLF F (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Adherence;AIDS related cancer;Algorithmic Analysis;Algorithms;angiogenesis;biobank;Bioinformatics;Biology;Biometry;Burkitt Lymphoma;cancer specimen resource;Cell Line;Cells;chronic infection;circular RNA;Clinic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Code;comparative;Comparative Study;Consultations;crosslink;Data;data analysis pipeline;Development;DNA;Endothelium;Epstein-Barr virus encoded RNA 1;Epstein-Barr Virus-Related Malignant Neoplasm;Florida;Funding;gammaherpesvirus;Gene Expression;Generations;glucose metabolism;Goals;HIV;Human;Human Herpesvirus 4;Human Herpesvirus 8;humanized mouse;Hybrids;Immune Evasion;In Vitro;in vitro Model;in vivo;innovation;Laboratories;Lesion;Link;Lymphoid Cell;Lymphomagenesis;Malignant Neoplasms;malignant stomach neoplasm;maxillofacial;Microprocessor;MicroRNAs;migration;Molecular;mouse model;Mus;novel;novel therapeutic intervention;Oncogenic;Oral;Palate Kaposi's Sarcoma;Pathogenesis;Pathology;Pathway interactions;Patients;Phenotype;programs;Proliferating;Protocols documentation;Publications;Publishing;Quality Control;recombinant virus;recruit;Reporting;Reproducibility;Research;Resolution;RNA;RNA Splicing;Role;Sampling;Seminal;Services;South Africa;System;Techniques;Therapeutic Intervention;Tissues;Transcript;transcriptome;transcriptome sequencing;transcriptomics;tumor;tumorigenesis;Universities;Untranslated RNA;Viral;Viral Proteins;Virus;Virus Latency;Xenograft procedure

PROJECT_TITLE: Noncoding RNAs in gamma-Herpesvirus Biology and AIDS Malignancies


ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROGRAM NARRATIVE Tumor metastasis to the liver is a leading cause of cancer death in the United States, and it is known to be associated with the increasing prevalence of obesity and non-alcoholic fatty liver disease. This Program represents the only coordinated, multi-investigator effort nationwide to focus on the causes of and approaches to address liver metastasis from cancers of the prostate, pancreas, and colon. Successful completion of the Program will lead to new targets for treatments for patients with liver metastasis.

PI_NAMEs: BHOWMICK, NEIL A.;LU, SHELLY CHI-LOO (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Acceleration;Address;Adopted;Animal Model;Bioinformatics;Biometry;cancer cell;Cancer Etiology;cancer type;Carcinoma;CD36 gene;Cessation of life;Clinical;Collaborations;Colon;Colon Carcinoma;Complement;Data;Dietary Intervention;Disparate;Doctor of Philosophy;Effectiveness;Endoglin;endoplasmic reticulum stress;Engraftment;Ensure;Environment;Epithelium;Extracellular Matrix;extracellular vesicles;falls;Fatty acid glycerol esters;Fatty Liver;Glutamate-Ammonia Ligase;Glutamine;glycogen synthase kinase 3 beta;Goals;Growth;Health Personnel;Healthcare Systems;Hepatic;Hepatic Stellate Cell;Hepatocyte;High Fat Diet;Histone Deacetylase;Home;Human;human tissue;Hyaluronic Acid;In Vitro;innovation;innovative technologies;Institution;Investigation;Kupffer Cells;Liver;liver development;Los Angeles;Macrophage;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Medical center;Metabolic;Metastatic Neoplasm to the Liver;methionine adenosyltransferase;MicroRNAs;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Neoplasm Circulating Cells;Neoplasm Metastasis;non-alcoholic fatty liver disease;novel therapeutic intervention;Obesity;Oncogenic;Pancreas;Pathway interactions;Patients;permissiveness;pharmacologic;Phenotype;Prevalence;Primary Neoplasm;programs;Prostate;prostate cancer metastasis;Proteins;Publishing;recruit;Regulation;Research;Research Personnel;Resistance;Resources;Role;saturated fat;Signal Pathway;Signal Transduction;Signaling Protein;Specimen;success;System;Terminal Disease;Testing;Tissues;tool;tumor;Tumor Expansion;tumor growth;tumor microenvironment;Tumor Promotion;Tumor-Derived;United States;Work

PROJECT_TITLE: Determinants of Liver Metastasis


ORG_CITY: MADISON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE – OVERALL Targeted radionuclide therapies are a type of cancer treatment that can be injected into a patient’s vein and, after circulating through the patient’s body, these will preferentially accumulate in tumors and selectively deliver radiation to these locations. Radiation can damage tumors in a way makes them more susceptible to being killed by a patient’s own immune cells. Here, we will evaluate what effects targeted radionuclide therapies have on immune recognition of tumor cells and we will test whether these agents may enhance response to diverse forms of cancer immunotherapy – all in an effort to develop non-toxic, curative treatment approaches for patients with metastatic cancers of any type.

PI_NAMEs: MORRIS, ZACHARY SCOTT;WEICHERT, JAMEY P (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: adaptive immunity;Advisory Committees;Age;anti-tumor immune response;antigen-specific T cells;Antigens;Antitumor Response;Award;Bioinformatics;Biometry;burden of illness;cancer immunotherapy;Cancer Patient;cancer therapy;cancer type;Canis familiaris;Categories;Cells;clinical translation;clinically relevant;Clonal Expansion;Companions;Complex;Core Facility;curative treatments;cytokine;Data;Development;Disease;Disseminated Malignant Neoplasm;Distant;Dose;Dose Rate;dosimetry;Ensure;exhaustion;experience;External Beam Radiation Therapy;FDA approved;Funding Mechanisms;Image;Immune;Immune checkpoint inhibitor;Immune system;Immune Tolerance;immunogenicity;Immunologics;immunoregulation;Immunosuppression;Immunotherapy;improved;in situ vaccine;in vivo;Industry Collaboration;Institution;Interferon Type I;Investigational Therapies;Knowledge;Leadership;Ligands;Location;Low Dose Radiation;Malignant Neoplasms;Mediating;Methods;Microscopic;Modality;Modeling;Molecular Target;multidisciplinary;Mus;Mutation;neoantigens;neoplastic cell;next generation;novel;Oncology;Patients;Pharmaceutical Preparations;Predisposition;Process;Program Research Project Grants;programs;Protocols documentation;Radiation;Radiation therapy;Radiochemistry;Radioisotopes;Radiolabeled;Radionuclide therapy;Radiopharmaceuticals;receptor;Regimen;Research;research clinical testing;research facility;Resources;response;Role;Safety;Services;Site;success;T cell infiltration;T cell response;T-Cell Activation;Testing;Therapeutic;Toxic effect;tumor;Tumor Immunity;tumor microenvironment;Tumor-infiltrating immune cells;Vaccines;vector;Veins;Whole-Body Irradiation

PROJECT_TITLE: Molecular Targeted Radionuclide Therapy for Tumor Immunomodulation and Enhancing Immunotherapy Response


ORG_CITY: PHILADELPHIA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Once diagnosed with lung cancer, a patient typically undergoes diagnostic bronchoscopy and/or therapeutic surgery. These procedures carry a 40% failure rate due to missed tumors, positive margins, un-identified lymph nodes, and synchronous cancers. Our Project will address this problem using near- infrared optical imaging technology.

PI_NAMEs: SINGHAL, SUNIL  (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Achievement;Affect;American;Attention;bench to bedside;Biopsy;Bronchoscopes;Bronchoscopy;Cancer Patient;cancer surgery;Clinical;clinical translation;Clinical Trials;Complex;Computer software;Contrast Media;Data;data management;design;Development;Devices;Diagnosis;Diagnostic;Diagnostic Procedure;Disease;Dyes;efficacy trial;Endoscopes;Endoscopy;Equipment;Excision;experience;Faculty;Failure;first-in-human;flexibility;Goals;Goggles;Grant;Healthcare;human imaging;Image;Image-Guided Surgery;Imaging Device;imaging platform;Imaging technology;improved;improved outcome;Individual;innovation;Joints;Lead;Libraries;Life;Light;Lung nodule;lymph nodes;Malignant neoplasm of lung;Malignant Neoplasms;Methodology;Molecular;molecular imaging;Molecular Target;Near-infrared optical imaging;neoplastic cell;Nodule;Non-Small-Cell Lung Carcinoma;Operative Surgical Procedures;optical imaging;Optics;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Persons;Polyps;Procedures;programs;Protocols documentation;Publications;Research;Robotics;Science;skills;small molecule;Staging;standard of care;success;surgery outcome;Technology;Testing;Therapeutic;Therapeutic procedure;Tracer;Translating;tumor;tumor microenvironment;United States National Institutes of Health;Validation;wearable device;Work

PROJECT_TITLE: Intraoperative Near Infrared Molecular Imaging of Lung Cancer


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: OVERALL NARRATIVE The Cyclin D-Cdk4/6-Rb-E2F pathway normally integrates external and internal signals to control cell cycle progression at the G1/S transition of the cell cycle. Alterations in the Cyclin D-Cdk4/6-Rb-E2F pathway are found in the vast majority of human cancers. These alterations are thought to increase the proliferative potential of cancer cells. Here we propose an in-depth mechanistic investigation of all levels of the Cyclin D-Cdk4/6-Rb-E2F pathway to gain novel insights into fundamental aspects of the mechanisms of action of this pathway in cells, with the hope that these studies will reveal novel ways to block the proliferation of cancer cells in patients.

PI_NAMEs: RUBIN, SETH MICHAEL;SKOTHEIM, JAN M (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Automobile Driving;Binding;Binding Sites;Breast Cancer Treatment;cancer cell;Cancer Control;cancer genetics;Cancer Patient;cancer therapy;cancer type;CCNE1 gene;Cell Cycle;Cell Cycle Kinetics;Cell Cycle Progression;Cell Cycle Regulation;Cell division;cell growth;cell preparation;Cell Proliferation;Cells;Cellular biology;Clinic;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Consensus;Cyclin D1;Cyclin-Dependent Kinases;design;Development;Dissociation;DNA;DNA biosynthesis;E2F transcription factors;Event;experimental study;Family member;G1 Phase;G1/S Transition;Genes;Genetic Transcription;genome editing;Goals;Human;imaging approach;improved;Inhibition of Cell Proliferation;inhibitor;innovation;insight;interdisciplinary approach;Investigation;kinase inhibitor;Knowledge;Malignant Neoplasms;Measures;Medicine;Modeling;Molecular;molecular imaging;Normal Cell;novel;novel strategies;novel therapeutic intervention;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Phosphorylation;Phosphotransferases;Post-Translational Protein Processing;Pre-Clinical Model;Program Research Project Grants;programs;Proliferating;protein protein interaction;Proteomics;Recurrence;Regulation;response;Retinoblastoma Protein;retinoblastoma tumor suppressor;S phase;Series;Signal Transduction;Structural Biochemistry;structural biology;success;Systems Biology;targeted treatment;Technology;Testing;Therapeutic;tumor;Tumor Suppressor Proteins;Work

PROJECT_TITLE: Determining and targeting mechanisms controlling cancer cell division


NIH_SPENDING_CATS: Childhood Injury;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care;Suicide;Suicide Prevention

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE This quasi-experimental study takes advantage of a natural experiment in a health system that implemented universal teen suicide prevention with confidential care to conduct a quasi-experimental, hybrid type-2 pragmatic implementation study. The study will test the extent to which implementation of population-based teen suicide prevention with confidential care increased safety planning and reduced suicide-related events among teens with preventive visits, and whether receipt of confidential care is associated with increased safety planning.

PI_NAMEs: LAPHAM, GWEN  (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: 17 year old;Academy;Acute;Address;Adult;American;Black race;Caring;Cause of Death;Clinic;Clinical;comparison group;cost;design;Disclosure;Effectiveness;Electronic Health Record;Emergency department visit;Event;evidence base;Female;follow-up;Foundations;Fright;future implementation;Gender expansive;Health;Health Services Accessibility;Health system;Hispanic;Hospitalization;Hybrids;implementation barriers;implementation evaluation;implementation strategy;implementation study;improved;improved outcome;Integrated Health Care Systems;Intervention;Link;National Institute of Mental Health;Natural experiment;Outcome;Parents;Pediatrics;Phase;population based;pragmatic implementation;pragmatic trial;Prevalence;prevent;Prevention program;Preventive;Primary Care;primary care clinic;primary care practice;primary care provider;primary care visit;Privacy;privacy protection;Provider;Public Health;Quasi-experiment;Recommendation;reducing suicide;Risk;risk mitigation;Safety;screening;sexual minority;Standardization;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;System;Teenagers;Testing;Time;Training;treatment as usual;United States Preventative Services Task Force;Visit;Youth

PROJECT_TITLE: Effectiveness of teen suicide prevention with confidential care: An implementation study across 30 primary care clinics

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Climate-Related Exposures and Conditions;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Excess risk for Alzheimer’s disease-related dementias (ADRD) persists among older Black and Latino adults, and disparities in vascular risk factors (stroke, hypertension, diabetes, obesity, and hyperlipidemia) are likely major drivers of these inequities. To tackle racial inequities in ADRD and their vascular mechanisms we need to understand racially patterned, modifiable environmental stressors such as limited access to green space, high exposure to air pollution, noise, extreme heat, neighborhood deprivation and violence. The proposed research will quantify how multiple environmental stressors simultaneously are associated with stroke and vascular risk factors for ADRD among Black, Latino, and White middle-aged adults; as well as cognitive function, cognitive decline, and neuroimaging biomarkers of ADRD risk in older adulthood.

PI_NAMEs: PESCADOR JIMENEZ, MARCIA IXCHEL (contact)

PROJECT_TERMS: Address;Adult;Affect;African American population;Air Pollution;Alzheimer's disease related dementia;Alzheimer's disease risk;Attention;Behavioral;Biological;Black Populations;Black race;Blood Vessels;brain volume;Cerebral small vessel disease;climate change;climate-related health;Cognitive;cognitive function;cohort;Communities;Coupled;Data;Data Set;deep learning algorithm;Dementia;dementia risk;deprivation;Diabetes Mellitus;Dimensions;Disparity;Environment;Environmental Exposure;Environmental Impact;Environmental Risk Factor;environmental stressor;epidemiology study;ethnic disparity;ethnic diversity;Ethnic Origin;Ethnic Population;experience;Exposure to;extreme heat;follow-up;Foundations;Funding;Goals;Green space;Health;healthy aging;Hippocampus;Hyperlipidemia;Hypertension;Imagery;Impaired cognition;Individual;Inequity;Intervention;Joints;late life;Latino;Latino Population;Life Experience;Link;Measures;Mediating;middle age;Neighborhoods;Nerve Degeneration;neuroimaging marker;neurovascular;Noise;Obesity;older adult;Outcome;Outcome Measure;Pathway interactions;Pattern;prevent;Prevention Research;Process;Race;racial disparity;racial diversity;racial population;Reasons for Geographic And Racial Differences in Stroke;Research;Resources;Risk;Risk Factors;Risk Reduction;Sampling;Sampling Studies;Statistical Methods;Stress;stressor;Stroke;Time;Vascular Diseases;vascular risk factor;Violence;Work

PROJECT_TITLE: Race/ethnicity and Environmental Stressors: POtential drivers of Dementia and stroke inequities RESPOnD


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: PETERSBURG

ORG_NAME: VIRGINIA STATE UNIVERSITY

ORG_STATE: VA

PHR: OVERALL: PROJECT NARRATIVE The overarching goal of the Virginia State University (VSU)-Virginia Commonwealth University (VCU) Massey Cancer Center (MCC) PartnErship for CancEr Disparities Research and Training (SUCCEED) program is to lead in the transformation of cancer-related outcomes for Virginians and to serve as a model of transdisciplinary disparities research. The institutions will jointly conduct pilot research projects addressing local, cancer-related health disparities and will develop a training program for VSU faculty and undergraduate students designed to attract and prepare investigators for careers in cancer disparities.

PI_NAMEs: FAISON, MILTON O (contact);ROBERTS, DANIEL M.

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TERMS: Address;Affect;African American;anti-cancer research;Black Populations;Black race;Cancer Burden;Cancer Center;cancer health disparity;career;career development;Cause of Death;Collaborations;Colorectal Cancer;Communities;community partnership;Comprehensive Cancer Center;Data;Death Rate;design;Development;Diagnosis;Disease;Disparity;Economics;Education;Elements;Emotional;Evaluation;experience;Faculty;Family;Fostering;Funding;Funding Agency;Goals;Growth;Health;Health Disparities Research;health disparity;health inequalities;Historically Black Colleges and Universities;Individual;Infrastructure;Institution;Intervention;Journals;K-Series Research Career Programs;Knowledge;Lead;Liver;Localized Malignant Neoplasm;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Massey Cancer Center at the Virginia Commonwealth University;meetings;member;Mentors;minority investigator;minority undergraduate;Modeling;mortality;multidisciplinary;Nature;neoplasm registry;Outcome;Output;Pattern;Peer Review;Phase;Pilot Projects;Positioning Attribute;Prevention;programs;Publications;Recording of previous events;Research;Research Activity;Research Personnel;Research Project Grants;research study;Research Support;Research Training;Resources;rural dwellers;science education;Social Well-Being;statistics;Students;summer research;survivorship;Testing;Training;Training Activity;Training and Education;Training Programs;undergraduate student;Underrepresented Minority;Universities;Virginia;Vision;Vital Statistics

PROJECT_TITLE: 2/2 VSU-MCC Partnership for Cancer Disparities Research and Training program (SUCCEED)


PHR: OVERALL: PROJECT NARRATIVE Recognizing that one of the greatest areas of need for pancreatic cancer patients is the rapid translation of therapies to the clinic, our Tissue Procurement, Pathology, and Genomics Core and Integrative Quantitative Sciences Core work seamlessly with the projects to process and analyze data from each of the projects and for the Selective Targeting of Pancreatic (SToP) Cancer SPORE as a whole. Thus the foremost goal of our SToP Cancer SPORE is to establish a new paradigm for clinical trial design based on cutting edge research that is not isolated to a single therapy or biomarker.

PI_NAMEs: YEH, JEN JEN  (contact)

PROGRAM_OFFICER_NAME: NOTHWEHR, STEVEN F

PROJECT_TERMS: Address;Advocate;aging population;Area;Biological Markers;biomarker identification;Cancer Etiology;career;Cellularity;Cessation of life;chemotherapy;chimeric antigen receptor T cells;Clinic;clinical biomarkers;clinical care;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;Colorectal Cancer;combinatorial;Complex;Consensus;Consent;Data;Dedications;design;Desmoplastic;Development;Diagnosis;Disease;early phase clinical trial;effector T cell;Environment;Environmental Risk Factor;Epigenetic Process;Etiology;Frequencies;Gene Mutation;Generations;Genetic;Genomics;Goals;Immunosuppression;Incidence;individualized medicine;Industry;innovation;Institution;International;KRAS2 gene;Lead;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Modeling;multidisciplinary;Mutation;Myeloid-derived suppressor cells;Names;Neoadjuvant Therapy;neoplastic cell;next generation;novel;novel therapeutics;oncology trial;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;Pathology;Patients;Pilot Projects;Population;pre-clinical;precision oncology;Prevalence;Process;programs;recruit;Research;research and development;Research Personnel;Sampling;Science;Solid Neoplasm;Survival Rate;T cell therapy;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapy resistant;Time;Tissue Procurements;Tissues;translational goal;Translational Research;translational scientist;translational therapeutics;Translations;tumor;tumor microenvironment;Tumor Promotion;tumor-immune system interactions;Work

PROJECT_TITLE: Selective Targeting of Pancreatic Cancer SPORE


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: COLUMBIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: NARRATIVE This proposal emphasizes on evaluating the therapeutic potential use of induced pluripotent stem cell derived neural stem cells to deliver microRNA to advanced brain tumors. Once validated, this therapeutic strategy has a great potential to be integrated into the clinical care regimen for brain tumor therapy.

PI_NAMEs: BHERE, DEEPAK  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Address;Adjuvant Chemotherapy;Adult;Aftercare;Award;Beds;Blood - brain barrier anatomy;Brain;Brain Neoplasms;Cell Differentiation process;cell growth;Cell Line;Cell Proliferation;Cells;Central Nervous System Diseases;chemotherapy;Clinical;clinical care;clinical translation;Data;Development;Diagnosis;Disease;Drug Delivery Systems;effective therapy;Encapsulated;Engineering;Ensure;Epidermal Growth Factor Receptor;Etiology;Excision;exosome;Extracellular Matrix;Flow Cytometry;fluorescence imaging;Ganciclovir;Glioblastoma;Goals;Growth;image guided;imaging agent;Immune;immune activation;immune clearance;Immune response;Immune system;Immunity;Implant;implantation;In Vitro;in vivo;induced pluripotent stem cell;Kinetics;Knowledge;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Mentors;MicroRNAs;migration;Modeling;Molecular;mouse model;Mus;neoplastic cell;nerve stem cell;novel;Operative Surgical Procedures;Pathway interactions;Patients;Phase;Positron-Emission Tomography;Primary Brain Neoplasms;Prognosis;promoter;Proto-Oncogene Proteins c-akt;Publishing;Radiation therapy;Regimen;Resected;response;restoration;Role;Safety;Signal Transduction;Simplexvirus;Small RNA;STAT3 gene;stem cells;success;suicide gene;Surgically-Created Resection Cavity;Survival Analysis;synergism;System;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Therapeutic Agents;therapeutic miRNA;therapy development;Thymidine Kinase;Time;Treatment Efficacy;treatment strategy;tumor;Tumor Burden;Tumor Debulking;tumor microenvironment;Tumor Volume;Up-Regulation;Validation

PROJECT_TITLE: microRNA therapies for advanced brain tumors

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CORAL GABLES

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Suppression of anti-tumor immune response is a major mechanism facilitating the progression and therapeutic resistance of glioblastoma (GBM), the most malignant primary brain tumor. The objective of this project is to gain mechanistic insight into how differential accumulation and function of myeloid-derived suppressor cell (MDSC) subtypes in males versus females contribute to persistent GBM growth via suppression of local and systemic immunity, regulation of the complement system and re-programing the tumor microenvironment. The successful completion of this proposal will elucidate novel interventions targeting MDSC subset variation and account for sex as a biological variable for improved immunotherapy response, which will further be developed as part of my independent research program.

PI_NAMEs: BAYIK WATSON, DEFNE  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Accounting;Address;Adoptive Transfer;antagonist;anti-CTLA4;anti-PD-1;anti-tumor immune response;Attenuated;autocrine;Behavior;Blood Vessels;Bone Marrow;cancer stem cell;Cancer Vaccines;CAR T cell therapy;Cell Lineage;Cell Proliferation;Cells;chemotherapy;Chimera organism;Circulation;clinical efficacy;Clinical Trials;clinically relevant;Complement;complement system;density;Development;Disease;Disease Outcome;drug candidate;drug repurposing;efficacy evaluation;experimental study;Female;fludarabine;Foundations;Frequencies;Gene Expression Profile;Generations;genetic signature;Germ Cells;Glioblastoma;granulocyte;Growth;immune activation;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immunity;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Impairment;improved;In Vitro;in vitro activity;in vivo;Incidence;Individual;Infiltration;inhibitor;insight;Interleukin-1 beta;Intervention;Knock-out;Laboratories;Left;male;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Mediator;monocyte;Mus;Myeloid-derived suppressor cells;neoplastic cell;novel;Oncolytic viruses;OX40;Pathogenesis;Pathway Analysis;Pathway interactions;Patient-Focused Outcomes;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Phase;Play;polarized cell;Population Heterogeneity;Pre-Clinical Model;Predisposition;Primary Brain Neoplasms;Production;Prognosis;programs;receptor;Regulation;Reporting;Research;response;Role;Serum;sex;sex as a biological variable;Sex Differences;standard of care;stem cell self renewal;success;T-Cell Activation;T-Lymphocyte and Natural Killer Cell;Testing;Therapeutic;therapeutic target;therapy outcome;therapy resistant;transcriptome;treatment response;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumor-immune system interactions;tumorigenesis;Variant;women patients;women versus men

PROJECT_TITLE: Role of myeloid-derived suppressor cells in local and systemic immunosuppression in glioblastoma


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Mental Health;Prevention;Social Determinants of Health

ORG_NAME: LOYOLA MARYMOUNT UNIVERSITY

PHR: Project Narrative The number of people in the U.S. living with lung cancer is expected to increase by 25% (from 571,340 to 724,610) in the next decade, and the majority (95%) of lung cancer patients report experiencing lung cancer stigma (i.e., the perception and internalization of negative appraisal from others attributed to one’s lung cancer)—which is associated with adverse psychological and physical health outcomes. There is an urgent unmet public health need to develop psychosocial interventions to reduce lung cancer stigma and improve quality of life for this understudied cancer group. This project will fill a critical gap in the field of cancer control science by adapting an existing patient-focused, self-compassion intervention to target the unique, disease- specific issue of lung cancer stigma, address anticipated delivery challenges, and pilot test the efficacy of the adapted intervention on reducing stigma for lung cancer patients.

PI_NAMEs: WILLIAMSON, TIMOTHY J (contact)

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: Address;Adult;Anxiety;Area;Attenuated;Basic Behavioral Science;Behavioral;behavioral and social science;Behavioral Research;Behavioral Sciences;Breathing;cancer care;Cancer Control;Cancer Intervention;Cancer Patient;career development;Clinical;Cognition;Compassion;Competence;Data;depressive symptoms;design;Development;Diagnosis;Disease;Disease Progression;Distress;efficacy testing;experience;Feeling;Focus Groups;Future;Goals;Health;Health Sciences;improved;Individual;internalized stigma;Intervention;Interview;Investigation;Link;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Measures;Meditation;Memorial Sloan-Kettering Cancer Center;Mental Health;Mentors;Mentorship;Methods;mindfulness;novel;Oncology;Outcome;Participant;patient population;Patients;Perception;Persons;Phase;physical conditioning;pilot test;Population;Positioning Attribute;post intervention;preference;Process;Protocols documentation;psychoeducation;psychologic;psychosocial;Psychosocial Influences;Public Health;Quality of life;randomized, clinical trials;Reaction;Regrets;Reporting;Research;Research Personnel;responders and non-responders;Sampling;screening;secondary outcome;self-compassion;Shame;Site;Smoking;social influence;social science research;social stigma;Source;standard of care;statistics;Stressful Event;Structure;synergism;telehealth;Testing;theories;therapy development;Training;Translating;Translations;understudied cancer;United States National Institutes of Health

PROJECT_TITLE: Adapting and Testing a Novel Self-Compassion Intervention to Reduce Lung Cancer Stigma


ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: NARRATIVE DNA sequences can form structures that are “difficult-to-replicate,” which can serve as barriers to DNA replication and repair and lead to genome instability and cancer. Our proposal is designed to characterize the role of DNA2/MutSα complex in overcoming specific difficult-to-replicate structures, called G-quadruplexes, during DNA replication or repair. Our results will define the cellular pathways and molecular mechanisms involved in overcoming G-quadruplexes, will affirm that individuals with defects in these pathways are more susceptible to cancer, and will provide a solid foundation for new cancer treatment regimens.

PI_NAMEs: SHEN, BINGHUI  (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Aflatoxin B1;Binding;Binding Proteins;Biological;Cancer Biology;cancer cell;Cancer Etiology;cancer initiation;cancer therapy;Cells;Centromere;Chemical Exposure;Chemicals;Chromosomes;Complex;Defect;design;Development;DNA;DNA biosynthesis;DNA Double Strand Break;DNA Mismatch Repair Protein MSH2;DNA Repair;DNA replication fork;DNA Sequence;DNA Sequence Alteration;DNA Structure;Double Strand Break Repair;Elements;Environment;Environmental Risk Factor;Epigenetic Process;Excision;Excision Repair;Foundations;Funding;G-Quartets;Gene Expression;Gene Mutation;Genetic;Genome;Genomic Instability;Goals;helicase;Histones;Human;Impairment;In Vitro;Individual;Knowledge;Malignant Neoplasms;Mammalian Cell;Mediating;Microsatellite Repeats;Minisatellite Repeats;Modeling;Molecular;Movement;MSH2 gene;MSH6 gene;Mus;novel;Nuclear;nuclease;Pathway interactions;Phenotype;Pigments;Predisposition;Process;protoporphyrin IX;Radiation;recruit;repaired;replication stress;Resolution;response;RNA;Role;S phase;Signal Transduction;Single-Stranded DNA;Site;Solid;Source;Structure;synergism;Tail;telomere;Treatment Protocols;tumor progression;tumorigenesis;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Dynamic functions of DNA2 counteract DNA replication stresses and tumorigenesis

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Prevention;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_NAME: WISTAR INSTITUTE

PHR: Project Narrative The proposed research will determine the underlying mechanism(s) for increased cancer risk in individuals with the African-centric p53 hypomorph P47S. This hypomorph exists in over 800,000 African-descent individuals in the United States, and accomplishing these aims has important implications for understanding cancer risk in under-represented populations, and for informing personalized medicine approaches.

PI_NAMEs: MURPHY, MAUREEN E. (contact)

PROJECT_TERMS: Adopted;African;African American population;African ancestry;Alleles;Antioxidants;Apoptosis;biobank;Bioinformatics;Biological Assay;Biology;Bladder Neoplasm;Cancer Burden;cancer health disparity;cancer risk;cancer therapy;CD8-Positive T-Lymphocytes;Cells;chemotherapy;Chromatin Remodeling Factor;Cisplatin;Combined Modality Therapy;Cysteine;Cystine;Data;Data Analyses;Defect;efficacy testing;Ethnic Population;Funding;Genes;Genetic;Genetic Transcription;Genetic Variation;genotoxicity;Glutathione;Goals;Health;Human;human data;Immune;Immune checkpoint inhibitor;Impairment;Implant;improved;Incidence;Individual;individualized medicine;inhibitor;insight;Iron;Iron Overload;Laboratories;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Medicine;Minority;Modeling;Molecular Conformation;mouse model;Mus;mutant;Mutation;Myeloid-derived suppressor cells;neoplastic cell;NF-kappa B;NFKB Activation Pathway;novel;Open Reading Frames;Outcome;Performance;personalized medicine;Pharmaceutical Preparations;Play;Population;protein function;Proteomics;Protocols documentation;Publishing;Request for Applications;Research;Resistance;Risk Factors;Role;senescence;success;Testing;Therapeutic;Tissues;TP53 gene;Transactivation;tumor;tumor microenvironment;Tumor Suppression;Tumor Suppressor Proteins;Underrepresented Populations;United States;Variant;Xenograft procedure

PROJECT_TITLE: Functional Analysis of p53 Polymorphic Variants

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Osteoporosis;Physical Injury - Accidents and Adverse Effects;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Osteoporosis affects over 20 million Americans and leads to more than 2 million fractures yearly, including over 300,000 hip fractures. Current therapies reduce, but do not eliminate, the risk of fragility fracture. The successful completion of the proposed study will fundamentally improve the way established osteoporosis is treated and introduce a new concept in osteoporosis management.

PI_NAMEs: LEDER, BENJAMIN Z (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: advanced disease;Affect;Agonist;American;Anabolic Agents;analog;Animals;Biochemical Markers;bisphosphonate;bone;Bone Density;Bone Formation Stimulation;bone mass;Bone Resorption;Bone Resorption Inhibition;Bone Resorption Stimulation;bone strength;bone turnover;clinical development;Combined Modality Therapy;comparative;cortical bone;Distal;drug action;Dual-Energy X-Ray Absorptiometry;falls;Femur;Finite Element Analysis;Forteo;Fracture;fracture risk;fragility fracture;high risk;High Risk Woman;Hip Fractures;Hip region structure;hormone analog;Human;improved;Incidence;inhibiting antibody;inhibitor;Modeling;Monoclonal Antibodies;Morbidity - disease rate;mortality;mortality risk;Neck;older adult;Osteocytes;Osteogenesis;Osteoporosis;Parathyroid Hormone Receptor;parathyroid hormone-related protein;Patient-Focused Outcomes;Patients;Peripheral;Pharmaceutical Preparations;Porosity;Postmenopausal Osteoporosis;Postmenopause;prevent;primary endpoint;Proliferating;Property;PTH gene;Radial;radius bone structure;randomized, clinical trials;Recommendation;Regimen;Resolution;Risk;Risk Reduction;secondary endpoint;Serum;side effect;skeletal;Spinal Fractures;standard care;standard of care;Structure;Testing;Therapeutic;tibia;Vertebral column;Woman

PROJECT_TITLE: Combined Anabolic Therapy in Postmenopausal Osteoporosis

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Emerging Infectious Diseases;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Kaposi's sarcoma-associated herpesvirus (KSHV) causes several human cancers including Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease. These malignancies inflict morbidity and mortality to the society in US and worldwide. This project will investigate the mechanisms regulating the replication of KSHV by RNA modifications, and identify potential therapeutic targets for developing novel prevention and treatment approaches.

PI_NAMEs: GAO, SHOU-JIANG  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;African;Alternative Splicing;base;Binding;Binding Proteins;Biogenesis;carcinogenesis;Cell Physiology;cell type;Cells;clinically relevant;Communities;Country;CRISPR/Cas technology;crosslink;Data Set;epitranscriptome;Etiology;expectation;Funding;gain of function;Genetic Transcription;Genome;Goals;Herpesviridae Infections;Highly Active Antiretroviral Therapy;HIV Seropositivity;Human;Human Herpesvirus 8;Immunity;Immunoprecipitation;Individual;innovation;insight;Intervention;Kaposi Sarcoma;knock-down;Knock-out;Life Cycle Stages;loss of function;lytic replication;Malignant Neoplasms;Maps;Mediating;Messenger RNA;metaplastic cell transformation;Methyltransferase;MicroRNAs;Modeling;Modification;Morbidity - disease rate;mortality;mRNA Translation;Multicentric Angiofollicular Lymphoid Hyperplasia;neoplastic cell;new technology;novel;novel therapeutics;Nuclear Export;Nucleotides;overexpression;Pathogenesis;Patients;Phase;Point Mutation;Poly(A)+ RNA;Population;Prevention;primary effusion lymphoma;Prognostic Marker;programs;Protein Overexpression;Proteins;Reader;Reagent;Regulation;Resolution;reverse genetics;RNA;RNA Degradation;RNA immunoprecipitation sequencing;RNA Splicing;RNA Viruses;Role;Site-Directed Mutagenesis;Societies;Stains;System;Testing;therapeutic target;Time;Transcript;transcriptome;Translations;tumor;tumorigenesis;Viral;Virus Diseases;Virus Latency;Virus Replication;Work

PROJECT_TITLE: Regulation of KSHV replication by N6-methyladenosine (m6A)

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: This project will test the role of actin cortical contraction in microtentacle formation and the clustering of circulating breast tumor cells. The PI’s lab has established the counterbalance between MT extension and actin cortical contraction and identified specific molecular mechanisms to alter this balance. Innovative bioengineering approaches, animal models, PDX and live patient CTCs will be used to test these mechanisms of targeting the actin cortex to reduce microtentacles.

PI_NAMEs: MARTIN, STUART S (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Acetylation;Actins;Adjuvant Chemotherapy;Affect;Animal Model;Antineoplastic Agents;Behavior;Biomedical Engineering;Blood capillaries;Blood Circulation;Breast Cancer Cell;Breast Cancer Treatment;Breast Epithelial Cells;Calcium Signaling;Cancer Etiology;Cancer Patient;cancer therapy;cell growth;Cell membrane;Cells;Cessation of life;Chemicals;Clinical Treatment;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Data;Desmosomes;Digitoxin;Disease;Distant;drug development;drug discovery;Epithelium;Equilibrium;Extracellular Matrix;FDA approved;Foundations;Genes;Genetic;Growth;Hour;Image;improved;In Vitro;in vivo;inhibitor;innovation;Invaded;Lung;Lymphatic;MCAM gene;mechanical properties;mechanotransduction;Mediating;Metastatic breast cancer;Metastatic/Recurrent;Methods;Microfluidics;Microscopy;Microtubule Stabilization;Microtubules;Modeling;Molecular;Motility;Mus;Neoadjuvant Therapy;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;novel therapeutics;Operative Surgical Procedures;Organ;Ouabain;Outcome;Paclitaxel;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phosphotransferases;Post-Translational Protein Processing;precision medicine;pressure;Prognosis;Proteins;Regulation;response;Risk;Role;side effect;standard of care;Surface;System;targeted cancer therapy;Techniques;Testing;Therapeutic;therapeutic target;Tissues;Translating;treatment strategy;triple-negative invasive breast carcinoma;Tubulin;tumor;Tumor Promotion;whole animal imaging;Xenograft procedure;Zebrafish

PROJECT_TITLE: Tubulin microtentacles in detached mammary epithelial cells

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ORG_CITY: SALT LAKE CITY

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE Lung cancer is a global scourge responsible for 1.5 million patient deaths worldwide, and ~130,000 patient deaths in the USA this year alone. Despite these grim statistics, lung cancer treatment has been revolutionized by the fundamental scientific understanding that lung cancers can be genetically subdivided based on the presence of specific proto-oncogene mutations that, in turn, predict for responsiveness to FDA-approved pathway-targeted therapies. Here, we propose the use of experimental/preclinical models of KRAS- or BRAF-driven lung cancer in combination with inhibitors of cellular signaling pathways to define the importance of key pathways in lung cancer initiation, progression and therapy, with the overarching goal of developing a rational scientific foundation for the development of new combination therapy strategies to more effectively treat lung cancer patients.

PI_NAMEs: MCMAHON, MARTIN  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: acquired drug resistance;AKT1 gene;anti-cancer research;antitumor effect;Asbestos;autocrine;Autophagocytosis;Behavior;Benchmarking;Biochemical;Biological;BRAF gene;cancer cell;cancer initiation;Cancer Patient;cancer therapy;cancer type;Cell Line;Cell Physiology;cell transformation;Cessation of life;Characteristics;chemotherapy;Cigarette;Clinical;clinical development;clinically relevant;comparison control;Consult;Cytoprotection;cytotoxic;Data;design;Development;Disease;Disease remission;Disease Resistance;Drug resistance;Drug Targeting;EGFR gene;Epidermal Growth Factor Receptor;ErbB Receptor Family Protein;Evaluation;Event;Family;FDA approved;Foundations;Genes;Genetic;Genetic Engineering;Genetic Transcription;Genetically Engineered Mouse;Goals;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Human;Hydroxychloroquine;Immunotherapy;ineffective therapies;inhibitor;KRAS oncogenesis;KRAS2 gene;Ligands;Lipids;Lung Adenocarcinoma;lung cancer cell;lung tumorigenesis;Maintenance;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP2K1 gene;MEKs;Melanoma;Minority;Mission;Modeling;Molecular;Molecular Abnormality;mouse model;mRNA Expression;Mus;Mutation;Natural Killer Cells;neoplastic cell;new combination therapies;novel;Oncogenes;Oncogenic;Oncoproteins;Operative Surgical Procedures;pancreatic cancer patients;Pathway interactions;patient derived xenograft model;patient response;Patients;pharmacologic;Phosphotransferases;Physicians;PI3 gene;PIK3CA gene;Play;pre-clinical;Pre-Clinical Model;predicting response;predictive marker;programs;Protein Kinase;Proto-Oncogene Proteins c-akt;Proto-Oncogenes;PTEN gene;Publishing;Radiation;Radon;RAS driven cancer;Ras Inhibitor;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Research;Residual Neoplasm;Resources;response;Risk Factors;Role;Safety;Scientist;Scourge;Signal Induction;Signal Pathway;Signal Transduction;Solid;statistics;STK11 gene;success;Talents;targeted treatment;Testing;Therapeutic;tool;Toxic effect;translational impact;tumor;tumor progression

PROJECT_TITLE: Studying the initiation, progression and therapy of lung cancer in mouse models