ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE The proposed research is relevant to the NIBIB's mission through the development of integrated multi-coil B0 shim and radio-frequency technology for human brain imaging, including advanced design optimization, safety assessment and tailoring to clinical imaging protocols and workflow. The translation of proof-of- principle technology into a clinical tool is relevant to public health because it enhances the diagnostic value of brain MRI, thereby providing a true clinical benefit.

PI_NAMEs: VAUGHAN, JOHN T (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Area;Automobile Driving;bench-to-bedside translation;Brain;Brain imaging;brain magnetic resonance imaging;brain tissue;Clinical;clinical diagnostics;clinical imaging;cognitive function;Complex;Computer-Aided Design;Coupling;Cranial nerve diseases;Cranial Nerves;Dedications;Deposition;design;Development;Diagnostic;Diagnostic Imaging;diagnostic value;Dropout;Echo-Planar Imaging;Electromagnetic Fields;Electromagnetics;Elements;Engineering;Environment;Eye;Future;Generations;healthy volunteer;Human;Hybrids;Image;Image Analysis;imaging capabilities;improved;innovation;Iron;magnetic field;Magnetic Resonance Imaging;Maps;Mechanics;Medical Staff;Methods;Mission;Modeling;Morphologic artifacts;National Institute of Biomedical Imaging and Bioengineering;neuroimaging;novel;Ocular orbit;Optic Nerve;optic nerve disorder;Optic Neuritis;Pathology;Patients;Performance;Phase;Predisposition;Prefrontal Cortex;Protocols documentation;Public Health;radio frequency;Research;RF coil;Safety;safety assessment;Shapes;Signal Transduction;simulation;Sinus;Slice;System;Techniques;Technology;Testing;tool;Training;translational approach;Translations;Visualization

PROJECT_TITLE: Dynamic Multi-Coil B0 Shimming for Diagnostic MRI of Frontal Brain

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: TALLAHASSEE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE PTSD is a highly debilitating mental illness that is difficult to treat. We have proposed a novel neurosensory account of PTSD emphasizing a tripartite sensory-prefrontal-cortex-amygdala (SPA) pathology. Taking a mechanistic, cognitive-affective neuroscience approach to elucidate this SPA pathology, this project will generate rich insights to significantly advance the conceptualization and treatment of PTSD and related disorders.

PI_NAMEs: LI, WEN  (contact)

PROGRAM_OFFICER_NAME: TUMA, FARRIS KEITH

PROJECT_TITLE: A Neurosensory Account of Posttraumatic Stress Disorder


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Lymphatic Research;Mental Health;Neurosciences;Pediatric;Sleep Research

ORG_CITY: PORTLAND

ORG_DEPT: DENTISTRY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative We propose to study how poor sleep affects the glymphatic pathway – a network of channels that allow waste to exit the brain during sleep – in adolescents. Poor sleep is reported by an alarming number of adolescents worldwide and leads to an increased risk of motor vehicle accidents, poor school performance, impaired social functioning, and other adverse outcomes. This study will contribute to fundamental knowledge about sleep and brain function in a particularly vulnerable population and has broad ramifications from pre-clinical research to public health policy (e.g., school start times).

PI_NAMEs: PIANTINO, JUAN ANDRES (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent and Young Adult;adverse outcome;Affect;aging population;Alcohols;Algorithms;Alzheimer's disease related dementia;Area;Attention;Automobile Driving;Behavioral;Biological;Blood Vessels;Brain;brain magnetic resonance imaging;Cerebrum;Child;circadian;Clinical;clinical care;Clinical Research;Cohort Studies;Contrast Media;Cross-Sectional Studies;Data;design;Detection;Development;Disease;Ethics;Excision;Exposure to;Functional disorder;Gadolinium;glymphatic dysfunction;glymphatic function;glymphatic system;Goals;Health;Health Policy;Hour;Human;Impaired cognition;Impairment;improved;insight;interstitial;Knowledge;Link;Location;Longitudinal cohort;Magnetic Resonance Imaging;Measures;Mediating;Mediator;Memory;Methods;Morphology;Motor;National Heart, Lung, and Blood Institute;Neurocognitive;Neurocognitive Deficit;neurodevelopment;neuroimaging;new technology;Outcome;Patient Self-Report;Patients;Pediatric Research;Performance;Personal Satisfaction;poor sleep;pre-clinical;pre-clinical research;prevent;Procedures;Public Health;Recommendation;Reporting;Research;Risk;Role;Schools;secondary analysis;Sleep;Sleep Deprivation;Sleep Disorders;sleep quality;Slow-Wave Sleep;Social Functioning;solute;Students;Testing;Time;tool;Traumatic Brain Injury;twelfth grade;United States;vehicular accident;Veterans;Vulnerable Populations;Wakefulness;wasting;white matter

PROJECT_TITLE: The perivascular space: A structural link between inadequate sleep, glymphatic dysfunction, and neurocognitive outcomes in adolescents

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: KENT

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: KENT STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Significant differences in neurotransmitters have been identified between rodents and humans, and this biological variance may partially explain why medications for neurodegenerative diseases that often show promise during preclinical development in rodent models fail to elicit the same therapeutic effect in humans. The proposed project will greatly improve our knowledge of the impact of age on neurotransmitters and their associated behaviors in chimpanzees, our closest living relative whose brain naturally develops the pathologic hallmarks of Alzheimer's disease. By gaining a better understanding of species-specific alterations in neurotransmitters, we can potentially improve therapeutic efficacy for age-related neurodegenerative disorders.

PI_NAMEs: EDLER, MELISSA K. (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acetylcholine;Address;Adult;Affect;Age;age effect;age related;age related changes;age related neurodegeneration;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid beta-Protein;Atrophic;Autopsy;Axon;basal forebrain;Behavior;behavior test;Behavioral;Biological;Brain;Brain region;Cell Aging;Cerebrovascular Disorders;cholinergic;cholinergic neuron;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive performance;cohort;Corpus striatum structure;Cross-Sectional Studies;Data;Data Correlations;Dementia;Dopamine;Dorsal;Elderly;executive function;Exhibits;experience;flexibility;Freezing;Gene Expression;Gene Proteins;Homologous Gene;Human;Immunohistochemistry;Impaired cognition;improved;Individual;Knowledge;Length;Lesion;locus ceruleus structure;Macaca;Measures;Memory;Mental disorders;Midbrain structure;Modeling;Modification;Motor;motor behavior;motor impairment;Motor Skills;Nervous System Disorder;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;neuron loss;Neurons;neuropathology;neurotransmitter metabolism;Neurotransmitters;nonhuman primate;Norepinephrine;Pan Genus;Parkinson Disease;Pathologic;Pathology;Performance;Pharmaceutical Preparations;Physiological;Pongidae;Pontine structure;preclinical development;preservation;Primates;prospective;raphe nuclei;Reporting;Resources;Risk Factors;Rodent;Rodent Model;Sampling;Senile Plaques;Serotonin;sex;social;Social Behavior;Social Interaction;species difference;Specimen;Symptoms;System;Testing;Therapeutic Effect;tool;touchscreen;transcriptome sequencing;transmission process;Treatment Efficacy;Variant;Vascular Diseases;walking speed

PROJECT_TITLE: The effect of aging on neurotransmitters and motor performance in a primate model

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Breastfeeding, Lactation and Breast Milk;Cancer;Maternal Health;Nutrition;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Breastfeeding is protective against breast cancer but the mechanism underlying this protective effect is unknown. This application focuses on the ovarian derived hormone STC1 as the driver of the protective effect of breastfeeding.

PI_NAMEs: GERMAIN, DORIS A (contact)

PROGRAM_OFFICER_NAME: PERLOFF, MARJORIE

PROJECT_TERMS: Attention;Award;Blood Transfusion;Breast;Breast Cancer Prevention;Breast Cancer Risk Factor;Breast Feeding;Cell Differentiation process;Cell Proliferation;Child;Circulation;Clinical;Clinical Trials;Data;DDR2 gene;design;Duct (organ) structure;experimental study;Exposure to;Female;forging;Future;Goals;Grant;Harvest;Hormone secretion;Hormones;Human;Immune Evasion;in vitro activity;Incubated;Inflammation;inhibitor;Insulin-Like Growth Factor Binding Protein 4;Insulin-Like Growth Factor Binding Protein 5;Insulin-Like Growth Factor Receptor;Lactation;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;Mammary Neoplasms;Mediator;Messenger RNA;migration;Modeling;Molecular;Monitor;Mothers;Mouse Mammary Tumor Virus;mouse model;Mus;Neoplasm Metastasis;Oncogenes;Ovarian;Ovary;overexpression;Peptide Hydrolases;Postpartum Period;Pregnancy;Pregnancy-Associated Plasma Protein-A;prevent;Procedures;Proliferating;Proliferation Marker;Protease Inhibitor;protective effect;Proteins;Reporting;Risk;Role;Schedule;Serum;Signal Pathway;Signal Transduction;Snails;STC1 gene;STC2 gene;Testing;theories;Time;Tissues;Transfusion;Transgenic Mice;Translating;Trees;Trust;tumor;Wild Type Mouse;Work

PROJECT_TITLE: Exploring ovarian-derived hormone STC1 as the mediator of the protective effect of breast feeding against breast cancer.


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_CITY: RICHMOND

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: No technology to date can provide customized therapy that adapts to the individual’s needs with regard to the specific FoG triggering scenarios. The wearable sensor and smart-phone system proposed has the potential to detect different environmental triggers and deliver an optimized dose of vibration at the precise moment it is needed. For people who are isolated in their homes and at risk for falls due to FoG, this new technology has potential to improve their mobility, independence and quality of life; and have important economic benefits for patients, their families, and for the health-care system as a whole.

PI_NAMEs: CLOUD, LESLIE J;PRETZER-ABOFF, INGRID A (contact);ZHOU, GANG

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Awareness;Cellular Phone;Clinical;Controlled Environment;design;Detection;Devices;Dose;Economics;Elevator;Environmental Risk Factor;fall risk;Family;foot;Freezing;Frequencies;Gait;Goals;Healthcare Systems;Home;improved;Individual;individualized medicine;Intention;Medical;Mission;motion sensor;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;new technology;Operative Surgical Procedures;Parkinson Disease;Patients;Persons;Positioning Attribute;prevent;programs;psychologic;Psychological Factors;Quality of life;response;Stimulus;System;tactile stimulation;Technology;Testing;Therapeutic;Time;Universities;vibration;Virginia;Visual;Walking;wearable device;wearable sensor technology;Work

PROJECT_TITLE: SCH: Context-aware Freezing of Gait mitigation in real-world setting


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative This project will exploit a novel variant of DNA-encoded library (DEL) technology for the discovery of a plethora of bioactive small molecules that will be useful as chemical probes and drug leads. Many of these compounds will target proteins in the Ubiquitin Proteasome System (UPS). Both biochemical and cell-based screens will be employed to find these compounds.

PI_NAMEs: KODADEK, THOMAS J. (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TITLE: Novel platforms for the discovery of bioactive small molecules

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative This research plan focuses on understanding how potent bioactive molecules are made from simple peptide precursors. Knowledge gained from this proposal will allow the production of bioactive scaffolds, and possibly new therapeutics, with improved functions and properties.

PI_NAMEs: NAIR, SATISH K (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TITLE: Structure, Function, and Engineering of RiPP Biosynthetic Enzymes


ADMINISTERING_IC: DA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

ORG_CITY: Los Angeles

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE To understand the neural basis of behavior, it is important to move beyond correlational validations of hypotheses toward their causal validations in real-time and/or closed-loop perturbation experiments and to study naturalistic behaviors in unconstrained experiments. To achieve this goal, this program will develop novel multiscale neural network models of neural population activity that not only capture nonlinearity, but also enable the new capabilities for flexible inference and closed-loop control. These models and methods will greatly impact diverse domains of neuroscience by causally driving and testing new hypotheses, informing closed-loop experimental paradigms and data-collection, and enhancing neurotechnology for treating brain disorders.

PI_NAMEs: SHANECHI, MARYAM  (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: Accounting;Address;Admission activity;Architecture;Automobile Driving;Behavior;Behavior Control;behavior prediction;Behavioral;Brain;Brain Diseases;Brain region;Cognitive;cognitive function;Computer software;Data;Data Collection;Data Set;Dimensions;Dissociation;diverse data;Documentation;emotional functioning;Evolution;experimental study;flexibility;Future;Goals;high dimensionality;human data;Investigation;kinematics;Learning;learning network;learning strategy;Link;Masks;Measures;Methods;Modeling;Motor;motor behavior;multi-scale modeling;multiscale data;network architecture;neural;neural model;neural network;Neural Network Simulation;Neurons;Neurosciences;neurotechnology;Non-linear Models;nonhuman primate;novel;outreach;Population;Population Dynamics;Process;programs;Recurrence;Research Personnel;Residual state;Resolution;Sensory;Source;spatiotemporal;Structure;Testing;Time;tool;Training;Validation;wireless

PROJECT_TITLE: Novel neural network models of multiscale brain network dynamics and behavior with real-time inference and control capability

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-F (A1)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: CALGARY

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF CALGARY

ORG_STATE: AB

ORG_ZIPCODE: T2N 1N4

PHR: Program Director/Principal Investigator: Schryvers, Anthony B. PROJECT NARRATIVE Neisseria gonorrhoeae, the bacterial pathogen that causes gonorrhea, is considered a serious public health threat due to the emergence of “superbug” strains that are resistant to the last line of recommended antibiotics. The inability to effectively treat with antibiotics puts patients in danger of developing severe complications including infertility. With a global incidence rate of over 106 million new cases every year, including over 800,000 in the US, developing an anti-gonococcal vaccine has become an urgent priority. The objective of this program is to evaluate large-scale production and perform non-clinical toxicology studies of a highly promising vaccine candidate that targets the systems required for iron acquisition during infection by gonococci.

PI_NAMEs: GRAY-OWEN, SCOTT D;MORAES, TREVOR F;SCHRYVERS, ANTHONY BERNARD (contact)

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: Adolescent and Young Adult;Animal Model;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antigens;Antimicrobial Resistance;assay development;Bacteria;Binding;Binding Proteins;Biochemical;clinical development;Clinical Trials;clinically relevant;combat;Contracts;cross immunity;Development;Dose;Ectopic Pregnancy;Engineering;Ensure;Etiology;Evaluation;experience;experimental study;Female;Formulation;Future;Gonorrhea;Grant;Growth;Human;human male;Human Volunteers;Immune response;Immunity;in vitro Assay;Incidence;Industrialization;Infection;Infection prevention;Infertility;Investigational Drugs;Iron;large scale production;Legal;Life;Male urethral structure;manufacturing organization;Membrane;Methods;Modeling;monoclonal antibody production;mouse model;Mucous Membrane;Multi-Drug Resistance;mutant;Neisseria gonorrhoeae;novel;Oryctolagus cuniculus;pathogen;pathogenic bacteria;Patients;Pelvic Inflammatory Disease;Phase;Phase I Clinical Trials;phase I trial;Positioning Attribute;preclinical development;Principal Investigator;Procedures;Process;Production;programs;Proteins;Public Health;Quality Control;receptor;Recommendation;reproductive;reproductive tract;Research;resistant strain;scale up;Sexually Transmitted Agents;Sexually Transmitted Diseases;Specific qualifier value;Superbug;Surface;System;Testing;TFRC gene;tool;Toxic effect;Toxicology;Transferrin;Transferrin-Binding Protein B;Transgenic Mice;Vaccine Antigen;vaccine candidate;vaccine development;vaccine efficacy;vaccine evaluation;vaccine formulation;Vaccines;Variant

PROJECT_TITLE: Production of a Gonococcal Vaccine for Countering Antimicrobial Resistance


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Patient sexual harassment of staff is common in Veterans Affairs (VA) healthcare facilities. Patient harassment of staff reduces quality of care; negatively impacts staff wellbeing, burnout, and turnover; and contributes to an environment that tolerates other forms of harassment (e.g., toward women patients) and discrimination (e.g., based on race/ethnicity). Recent VA anti-harassment campaigns focus on harassment prevention, but additional work is needed to help staff respond to and cope with experiences of harassment when they occur. This pilot project will engage VA staff, leaders, and other stakeholders in the co-design of an intervention to guide immediate staff, clinic, and facility responses to patient harassment of staff in primary care settings, which serve as the entry point into VA care. The resulting intervention has the potential to increase staff well- being and quality of patient care, bolster ongoing anti-harassment efforts, and create a safe, respectful environment of care in which harassment is not tolerated.

PI_NAMEs: FENWICK, KARISSA  (contact)

PROJECT_TERMS: Address;Adoption;Adverse effects;Adverse event;adverse outcome;Affect;assault;Behavior;burnout;Caring;Characteristics;Chronic Disease;Client satisfaction;Clinic;Clinical;Committee Members;Communication;Complement;Complex;Consensus;coping;Data;decision making algorithm;design;Development;Discrimination;Disease Management;effectiveness/implementation trial;Elements;Emotional;Ensure;Environment;equity, diversity, and inclusion;Ethicists;ethnic discrimination;ethnic minority;Ethnic Origin;Evidence based intervention;experience;Exposure to;Feedback;Fellowship;Frontline worker;Funding;Goals;harassment;Health care facility;health care settings;holistic approach;implementation/effectiveness;improved;innovation;Internal Medicine;Intervention;Interview;Leadership;Literature;Medical;Medical Errors;men;Methodology;Morale;novel;operation;Participant;Patient Care;Patient Care Planning;Patients;Personal Satisfaction;Physicians;Pilot Projects;Policies;practice-based research network;Prevention;Primary Care;primary care practice;primary care provider;primary care setting;Primary Prevention;Procedures;Process;Protocols documentation;Provider;Quality of Care;Race;racial discrimination;racial minority;Reporting;response;Risk;Sexual Harassment;Site;Social Identification;Statutes and Laws;Surveys;Testing;therapy design;United States Department of Veterans Affairs;Veterans Health Administration;webinar;Woman;women patients;Women's Health;Work

PROJECT_TITLE: Designing a novel post-incident intervention to address patient harassment of staff in VA primary care settings

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Stroke

ORG_CITY: STONY BROOK

ORG_DEPT: NEUROLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative: Despite new therapies for stroke patients, over 50% still suffer significant disability or death. My research suggests that damage within the brain after stroke is quite variable. With novel techniques, I will study this phenomenon in-depth in hopes of developing more precise therapeutic approaches in stroke.

PI_NAMEs: NADKARNI, NEIL AVADHOOT (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acceleration;Address;Adhesions;Angiography;animal imaging;Antibodies;Area;Atherosclerosis;Autopsy;Beds;Biology;Blocking Antibodies;Blood flow;Blood Pressure;Blood Vessels;Brain;Brain Hypoxia;Brain Infarction;Brain region;Cancer Biology;CD31 Antigens;Cell Adhesion Molecules;cerebral microvasculature;cerebrovascular;Cerebrovascular system;Cessation of life;Clinical;Clinical Research;Clinical Trials;Confocal Microscopy;Cortical vasculature;cytotoxicity;Data;disability;Disease;Endothelium;Environmental sludge;Extravasation;Feedback;Goals;Heterogeneity;Histopathology;Hour;Human;Imaging Techniques;Impairment;improved;In Situ;in vivo;Infarction;Infiltration;Inflammation;Inflammatory Infiltrate;insight;Invaded;Investigation;Ischemia;Ischemic Penumbra;Ischemic Stroke;Knowledge;Lesion;Leukocytes;Link;Location;Magnetic Resonance Imaging;Measures;Mechanics;Mentorship;meter;Microcirculation;Microscopy;Middle Cerebral Artery Occlusion;migration;Molecular;mouse model;multidisciplinary;multimodality;Mus;neuroinflammation;Neurological outcome;neutrophil;Neutrophil Infiltration;novel;novel therapeutics;Obstruction;Optical Coherence Tomography;Outcome;Oxygen;Pathologic;Pathology;Patients;Pattern;Perfusion;Physiological;Physiology;Population;Positioning Attribute;post stroke;postcapillary venule;pre-clinical;preclinical study;programs;Property;recruit;Reperfusion Injury;Reperfusion Therapy;Research;Resolution;response;Risk;spatiotemporal;Stroke;stroke model;stroke outcome;stroke patient;stroke therapy;success;Surface;Techniques;Testing;Therapeutic;Therapeutic Index;Thrombectomy;Time;Tissues;Toxic effect;Transgenic Mice;Visible Radiation

PROJECT_TITLE: Defining the Spatiotemporal Underpinnings of Neutrophil Recruitment, Microvascular Flow, and Oxygenation in Ischemic Stroke


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Urologic Diseases

ORG_CITY: NORFOLK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: EASTERN VIRGINIA MEDICAL SCHOOL

PHR: PUBLIC HEALTH RELEVANCE This project will investigate the impact of osteopontin-induced prostatic fibrosis on lower urinary tract dysfunction. Defining the molecular players contributing to prostatic fibrosis and how it relates to urinary dysfunction will provide new diagnostic and therapeutic targets to enhance the treatment of lower urinary tract symptoms in men.

PI_NAMEs: POPOVICS, PETRA  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: 3-Dimensional;Age;Aging;Animal Model;Area;Autoimmune;autoimmune inflammation;Benign;Biological Assay;Biomedical Engineering;Bladder;Cancer Biology;career;career development;CD8-Positive T-Lymphocytes;Cell Communication;chemokine;Chronic;Clinical;clinical training;clinically significant;Coculture Techniques;Collagen;common symptom;cost;CXCL1 gene;cytokine;Data;Deposition;design;Detection;Deterioration;Development;Disease Progression;drug development;Economic Burden;Endocrinology;Environment;Epithelium;Estradiol;Extracellular Matrix;Familiarity;Fibronectins;Fibrosis;Functional disorder;Funding;Genetic;Goals;Healthcare Systems;IL6 gene;Immune;Immune response;immunopathology;Implant;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Inflammation;Inflammatory;Institution;Kidney;Knockout Mice;Knowledge;Link;Lower urinary tract;lower urinary tract symptoms;male;Mediating;Mediator;Medical;men;Mentors;Methods;Modeling;Molecular;Molecular Biology;Molecular Target;monolayer;Mus;new therapeutic target;novel;novel diagnostics;novel therapeutics;Organ;osteopontin;overexpression;Pathology;Pathway interactions;pharmacologic;Phosphoproteins;Physiological;Process;programs;Prostate;Prostatic;Prostatic Diseases;Prostatic Tissue;prostatitis;Proteins;public health relevance;Quality of life;Recovery;Reporting;Research;research and development;Research Personnel;Research Proposals;Role;Secondary to;Signal Transduction;skills;steroid hormone;Stream;Stromal Cells;subcutaneous;Symptoms;targeted treatment;Technology;Testing;Testosterone;Tissue Engineering;Tissues;Training;transmission process;urinary;Urination;Urology;Uropathogenic E. coli;Vocational Education

PROJECT_TITLE: Osteopontin: A Novel Mediator of prostatic inflammation and fibrosis


NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Microbiome;Nutrition;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE With little understanding as to its pathogenesis, colorectal cancer recurrence occurs in up to 40% of patients undergoing surgery, and when it does, it is almost universally fatal. This proposal is focused on studying a novel hypothesis in cancer recurrence and defining the role of intestinal microbes to influence cancer cells towards an invasive phenotype promoting tumor formation. These studies will provide transformative insights into the dynamic interaction between host-microbe-cancer that can be leveraged to provide novel interventions and therapeutics to prevent primary cancer and its recurrence.

PI_NAMEs: SHOGAN, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Address;Anastomosis - action;Automobile Driving;Bacteria;bacterial community;cancer cell;cancer diagnosis;cancer recurrence;career;career development;Cells;collagenase;Colorectal;Colorectal Cancer;colorectal cancer prevention;Colorectal Surgery;CT26;Data;Development;Development Plans;Diagnosis;Disease;Distal;Enterococcus faecalis;Environment;Excision;experimental study;Extracellular Matrix;Fatty acid glycerol esters;Funding;Germ-Free;Goals;gut microbes;gut microbiome;gut microbiota;healing;Health;High Fat Diet;Human;improved;improved outcome;In Vitro;in vivo;in vivo evaluation;insight;Intervention;Intestinal permeability;Intestines;Invaded;Knowledge;longitudinal analysis;Malignant Epithelial Cell;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mentors;Metagenomics;Metastasis Induction;Microbe;microbial;migration;MMP9 gene;Modeling;Mus;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;Oncologist;Operative Surgical Procedures;Organism;Pathogenesis;Pathway interactions;Patients;Peptide Hydrolases;Perioperative;Phenotype;Plasminogen;Play;Postoperative Period;prevent;Primary Neoplasm;Principal Investigator;Process;Proliferating;Rectal Cancer;Recurrence;Risk Factors;Role;Sampling;Scientist;Signal Pathway;Signal Transduction;Site;Surgeon;survival outcome;System;Testing;Therapeutic;Thinking;Time;Tissues;tumor;Tumor Cell Biology;Tumor Cell Invasion;tumor progression;Tumor Promotion;tumorigenesis;Urokinase;western diet;Work

PROJECT_TITLE: Elucidating the role and mechanisms by which collagenase producing intestinal bacteria promote colorectal cancer recurrence and metastasis following surgery.

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This study will examine the effect of prenatal and early life metals exposure on the developing brain, cognitive and adaptive function, and risk for autism spectrum disorder (ASD) and related traits. We will integrate novel tooth-based biomarkers of metals exposure into the Autism Spectrum Disorder Enriched Risk (ASD-ER) cohort, a unique collaborative of 13 prospective high familial risk for ASD populations. Because exposure to metals is common and our study is conducted in very young children there is great potential for intervention and broad public health impact.

PI_NAMEs: ANDRA, SYAM S;VOLK, HEATHER E (contact)

PROGRAM_OFFICER_NAME: LAWLER, CINDY P

PROJECT_TERMS: Adaptive Behaviors;Address;Affect;Age Months;age related;Area;autism spectrum disorder;autistic behaviour;autistic children;Award;Behavior;behavior measurement;Behavioral;Biological Markers;Brain;Brain region;brain volume;Chemicals;Child;Child Health;Childhood;Cognition;Cognitive;cognitive development;cohort;Collaborations;Collection;Corpus Callosum;cost effective;Cross-Sectional Studies;Data;data harmonization;deciduous tooth;Dental;Development;Developmental Delay Disorders;Diffusion;Dimensions;disorder risk;early childhood;Early Intervention;early life exposure;Elements;Enrollment;Environment;Environmental Exposure;Environmental Risk Factor;Equation;experience;Exposure to;fetal;Fiber;follow-up;Fostering;Goals;Heavy Metals;Image;Individual;Infant;Infrastructure;innovation;Intake;Intervention;Investments;Joints;Lasers;Lead;Lead levels;Learning;Life;Link;Liquid substance;Manganese;Measures;Metal exposure;Metals;Methods;model of autism spectrum disorder;Modeling;Morphology;Nature;Needs Assessment;neuroimaging;neurotoxic;Neurotoxins;novel;Nutrient;Outcome;Participant;Pathway interactions;Perinatal;Phenotype;Population;postnatal;prenatal;Problem behavior;Productivity;Property;prospective;Public Health;Publications;Recording of previous events;Research;Resources;Risk;Risk Factors;Sampling;Second Pregnancy Trimester;Siblings;Site;Structure;Surface;Technology;temporal measurement;Time;Time Study;Tooth structure;toxic metal;trait;Twin Studies;white matter;Work;Zinc

PROJECT_TITLE: Metals Dysregulation, Brain Development, and Autism Spectrum Disorder

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative The Successful Clinical Response In Pneumonia Therapy (SCRIPT2) Systems Biology Center will continue to delineate the complex host/pathogen interactions occurring at the alveolar level that lead to unsuccessful response to therapy in serious pneumonia. In SCRIPT2, we will determine whether models generated using high-dimension data describing the host, pathogen, microbiome, and clinical phenome in severe community- acquire pneumonia and hospital-/ventilator-acquired pneumonia can predict favorable or unfavorable clinical transitions/outcomes over the course of a pneumonia episode. We will query these models to identify potential therapeutic host, pathogen, and microbiome targets and determine when, whether, and how standard or investigational therapies can be applied to increase the likelihood of a favorable outcome.

PI_NAMEs: WUNDERINK, RICHARD G (contact)

PROGRAM_OFFICER_NAME: KWON, KEEHWAN

PROJECT_TERMS: 2019-nCoV;Admission activity;Alveolar;Bioinformatics;Blood specimen;Bronchoalveolar Lavage;Caring;Cessation of life;Clinical;clinical care;Clinical Data;clinical phenotype;Clinical Trials;clinically actionable;co-infection;cohort;Collaborations;community acquired pneumonia;Complex;COVID-19;COVID-19 pandemic;COVID-19 pneumonia;Critical Illness;Curettage procedure;Data;data management;Data Set;Databases;Direct Costs;disease model;Distal;DNA;Dose;Drug Kinetics;Enrollment;Epidemiology;Etiology;Evaluation;Flow Cytometry;Funding;Generations;Grant;high dimensionality;Hospitals;humanized mouse;Immune response;improved;Inbred Mouse;Infection;influenza epidemic;inhibitor;innovation;Intervention;Intubation;Investigational Therapies;Klebsiella;Laboratories;Lead;longitudinal analysis;Lung;Lung Transplantation;Mechanical ventilation;Metagenomics;microbial;microbiome;microbiome therapeutics;Modeling;Modification;molecular modeling;Morbidity - disease rate;mortality;mouse model;multidimensional data;Multiomic Data;multiple omics;Names;Nasopharynx;Nature;Nose;Nosocomial pneumonia;novel therapeutics;Outcome;participant enrollment;pathogen;Pathogenesis;Patient Care;Patients;Pharmacodynamics;pharmacologic;Phase;Phase II Clinical Trials;phenome;Pneumonia;pneumonia model;pneumonia treatment;predictive modeling;Procedures;Pseudomonas aeruginosa;Publishing;randomized trial;Research Personnel;Respiratory Mucosa;response;Risk;Sampling;seasonal influenza;severe COVID-19;single-cell RNA sequencing;Space Models;Staphylococcus aureus;superinfection;Systems Biology;Technology;Testing;Therapeutic;therapeutic target;Time;translational impact;treatment response;United States;Validation;ventilation;ventilator-associated pneumonia;Viral;Work

PROJECT_TITLE: Successful Clinical Response In Pneumonia Therapy (SCRIPT) Systems Biology Center


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dental, Oral, and Craniofacial Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Stroke

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: Project Narrative Transcranial ultrasound could facilitate a broad range of applications in imaging and therapy, such as functional imaging, intracerebral hemorrhage detection, brain perfusion evaluation, cerebrovascular disease diagnosis, neurological disorder treatment, and neuromodulation. Despite its promising potentials, transcranial ultrasound imaging remains difficult and limited largely because skulls cause severe phase aberration, leading to highly degraded ultrasound images. This project aims to address this major limiting factor by developing new machine-learning-based methods to extract the skull profile and speed of sound directly from backscattered ultrasound signals and therefore enable accurate phase aberration correction.

PI_NAMEs: HAN, AIGUO  (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: 3-Dimensional;Acoustics;Address;Adult;Algorithms;Architecture;Blood flow;Brain;brain based;Brain imaging;Cephalic;Cerebral hemisphere hemorrhage;Cerebrovascular Disorders;contrast enhanced;cranium;Data;deep learning;deep learning algorithm;design;Detection;Diagnosis;disease diagnosis;Environment;Evaluation;experimental study;Functional Imaging;Future;Goals;Hospitals;Human;Image;Image Enhancement;imaging modality;imaging probe;imaging study;Imaging Techniques;in silico;in vivo;Intensive Care Units;Ionizing radiation;Knowledge;Location;Machine Learning;machine learning method;Magnetic Resonance Imaging;Maps;Measures;Methods;microCT;Modality;Modeling;Monitor;Nervous System Disorder;neuroregulation;optoacoustic tomography;Organ;Performance;Perfusion;Phase;physical model;Physiologic pulse;Physiology;Play;portability;pre-trained model;Property;radio frequency;Rest;Role;Scanning;Signal Transduction;skull base;sound;Spatial Distribution;Speed;Stroke;stroke patient;superresolution imaging;synthetic data;Techniques;Testing;Thick;Time;Training;training data;transmission process;Transportation of Patients;trauma care;Traumatic Brain Injury;treatment planning;Ultrasonography;ultrasound;X-Ray Computed Tomography

PROJECT_TITLE: Toward ultrasound brain imaging via machine-learning-extracted skull profile and speed of sound


NIH_SPENDING_CATS: Bioengineering;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

PROJECT_TERMS: Algorithms;Alveolar;American;biodefense;Bioinformatics;bioinformatics resource;Biological;Chest;Clinical;clinical care;clinically actionable;collaborative environment;Communicable Diseases;Communication;Communities;Complex;computerized tools;Critical Care;Critical Illness;Data;Data Analyses;data dissemination;data submission;database schema;Databases;Disease;Emerging infection;Ensure;experimental study;FAIR principles;Fostering;Funding Mechanisms;Goals;Human Resources;improved;Infection;Information Dissemination;innovation;Institution;Interdisciplinary Study;Lung;mathematical model;meetings;member;Mentors;microbial;Modeling;Monitor;multidisciplinary;multiple omics;National Institute of Allergy and Infectious Disease;open source;outreach;pathogen;Pathogenesis;Patient Care;Pneumonia;pneumonia treatment;programs;public database;Publications;Reagent;recruit;repository;Research;Research Personnel;Resources;response;sample collection;Scientist;Societies;Specific qualifier value;Structure;Syndrome;Systems Biology;Technology;tool;Training Programs;treatment response;U-Series Cooperative Agreements;United States National Institutes of Health;web site;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Data Science;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pneumonia;Pneumonia and Influenza

PI_NAMEs: STARREN, JUSTIN B. (contact)

PROJECT_TERMS: Acceleration;Address;advanced system;Alveolar;Area;Awareness;Bioinformatics;Biological;Biological Models;Clinical;Clinical Data;Code;cohort;community acquired pneumonia;Complex;computer infrastructure;computerized tools;computing resources;Cytometry;Data;data infrastructure;data management;data modeling;data quality;Data Set;data sharing;Data Sources;Dependence;design;diverse data;empowerment;Ensure;Equilibrium;experience;Foundations;Frequencies;Future;Generations;Genome;Goals;health data;heterogenous data;high dimensionality;Hospitals;Human;improved;Informatics;Infrastructure;Ingestion;innovation;insight;Knowledge;Machine Learning;Medical;Metadata;Methods;Modeling;multidimensional data;multidisciplinary;Multiomic Data;Names;Nature;novel;open source;Outcome;Participant;pathogen;Pathology;patient subsets;Patients;Persons;Phase;phenome;Plant Leaves;Play;Pneumonia;pneumonia treatment;Preparation;Privacy;Process;Property;query tools;recurrent neural network;Reproducibility;Research;Research Personnel;Resources;response;Sampling;Science;Secure;Security;skills;Specimen;success;System;Systems Biology;Techniques;Time;tool;treatment response;ventilator-associated pneumonia;Weight

PROJECT_TITLE: Data Management and Bioinformatics Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases;Urologic Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Pancreatic cancer remains one of the most difficult cancers to detect and treat, due to late diagnosis and a lack of effective therapies. An antibody that recognizes PSCA, a target overexpressed in pancreatic cancer, will be engineered to deliver radioisotopes for the detection, and ultimately, highly targeted radiotherapy, of this deadly disease.

PI_NAMEs: WU, ANNA M (contact);ZETTLITZ, KIRSTIN ANJA

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: advanced disease;advanced pancreatic cancer;Affinity;Alpha Particles;Animal Model;Antibodies;antibody engineering;Antigen Targeting;Beta Particle;Biodistribution;Bioreactors;Blood;Bone Marrow;cancer therapy;Cause of Death;cell bank;Cell Line;Cell Surface Proteins;Cells;cGMP production;Clinical;Clinical Trials;design;Detection;Development;Diagnosis;Disease;Dose;Dose Fractionation;Dose Limiting;dosimetry;Drug Kinetics;effective therapy;Effectiveness;Engineering;Exhibits;expectation;FCGR2B gene;first-in-human;Fostering;Future;Hepatic;Hepatobiliary;Human;I131 isotope;Image;imaging study;Immunoglobulin Fragments;ImmunoPET;improved;improved outcome;Injections;Investigational New Drug Application;Kidney;Knock-in;Knock-in Mouse;KPC model;Label;Liver;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Modeling;Molecular Target;Monitor;mouse model;Mus;mutant;Mutation;Neuroendocrine Tumors;Normal tissue morphology;novel;novel therapeutic intervention;Nude Mice;Operative Surgical Procedures;Organ;overexpression;Pancreas;Pancreatic Adenocarcinoma;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;pancreatic neoplasm;Patients;Positron;Positron-Emission Tomography;preclinical efficacy;preclinical study;Probability;Process;Production;Property;prostate stem cell antigen;Proteins;Radiation;Radiation Dose Unit;Radiation Tolerance;Radioactivity;Radioimmunotherapy;Radioisotopes;Radiolabeled;Radionuclide Imaging;Radionuclide therapy;research clinical testing;Route;Safety;Solid Neoplasm;Staging;subcutaneous;success;targeted imaging;Targeted Radiotherapy;targeted treatment;Testing;theranostics;Therapeutic;Time;Tissues;Toxic effect;tumor;Tumor Antigens;tumor xenograft;uptake;Variant;Vial device;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Engineered anti-PSCA antibodies for immunoPET and targeted therapy of pancreatic cancer

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Biotechnology;Coronaviruses;Genetics;Human Genome;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

PI_NAMEs: SINGER, BENJAMIN DAVID (contact)

PROJECT_TERMS: 2019-nCoV;Alveolar;Alveolar Macrophages;Alveolus;Animal Model;B-Cell Antigen Receptor;Back;biobank;Bioinformatics;Biological;Biological Assay;Blood specimen;Bronchoalveolar Lavage;Cell Separation;Cells;Clinical;Clinical Trials;Complex;cost;COVID-19 pneumonia;Cryopreservation;Curettage procedure;cytokine;Data;Disease;DNA Methylation;Epithelial Cells;Epithelium;Epitopes;Expression Profiling;Flow Cytometry;Funding;Gene Expression;Gene Expression Profiling;Generations;genome-wide;Goals;Hour;Immune;immunopathology;Immunophenotyping;indexing;Inflammatory;information model;innovation;Interferon Type II;International;Knowledge;Laboratories;Lung;Mechanical ventilation;metagenomic sequencing;Modeling;multiple omics;Nature;next generation sequencing;Nose;novel;novel therapeutics;Participant;pathogen;Pathogenesis;Patients;Pneumonia;pneumonia treatment;Population;Procedures;Process;process optimization;protein expression;Protocols documentation;Publishing;Research Personnel;response;Role;Running;Sampling;sensor;severe COVID-19;Signal Transduction;single cell genomics;single cell technology;single-cell RNA sequencing;Structure;success;Systems Biology;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Technology;transcriptome;Work

PROJECT_TITLE: Technology Core


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

PHR: Protein arginine methyltransferases (PRMTs) influence gene expression and signaling pathways by catalyzing arginine methylation, including on histone and non-histone proteins. In malignant glioblastoma (GBM), cell mitosis is critical for tumor growth and survival therapy response. This application will investigate the mechanism and therapeutic targeting for protein arginine methylation regulation of GBM tumorigenicity by elucidating the role of protein arginine methyl transferase 6 (PRMT6) on regulating cell mitosis through directly arginine methylation of chromosome condensation 1 (RCC1), thereby regulating malignant GBM phenotype and GBM responses to therapies.

PI_NAMEs: CHENG, SHI-YUAN  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;Affect;antitumor effect;Arginine;Biological;casein kinase II;Cell division;Cell Physiology;Cell Shape;Cells;Chromatin;Chromosome Condensation;Chromosomes;Clinical;clinical application;Combined Modality Therapy;DNA Damage;enzyme substrate;Enzymes;Epigenetic Process;Event;experimental study;Gene Expression;Genetic;Glioblastoma;Goals;Growth;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;Histones;improved;in silico;In Vitro;in vivo;innovation;Knock-out;Knowledge;Learning;Malignant - descriptor;Malignant Neoplasms;Membrane;Messenger RNA;Methylation;Methyltransferase;Mitosis;Mitotic;Molecular;non-histone protein;novel;Nuclear;Organelles;Patient-Focused Outcomes;Patients;Phenotype;Phosphorylation;Phosphotransferases;Physical condensation;Play;Post-Translational Protein Processing;pre-clinical research;Process;Prognostic Marker;Property;Protein Analysis;protein arginine methyltransferase 2;Protein Family;protein function;Protein Inhibition;Protein Methylation;Protein-Arginine N-Methyltransferase;Protein-Serine-Threonine Kinases;Proteins;radiation response;Radiation therapy;recruit;Regulation;response;RNA Splicing;Role;Running;Serine;Signal Pathway;Signal Transduction;small molecule;standard care;standard of care;Substrate Interaction;temozolomide;Testing;therapeutic target;Threonine;Transferase;treatment response;treatment strategy;tumor;Tumor Biology;tumor growth;Tumorigenicity

PROJECT_TITLE: Role of Protein Methylation in Cell Mitosis and Glioblastoma

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Genetics;Human Genome;Pediatric;Social Determinants of Health

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Despite the deleterious implications of neighborhood disadvantage for child development, a large proportion of exposed youth demonstrate adaptive functioning and competency in the face of this adversity. The current proposal focuses scientific attention on children’s strengths in the face of chronic stressors by examining developmental trajectories of three domains of resilience (academic, social, psychiatric) and identifying epigenetic biomarkers of resilience trajectories. By illuminating the developmental etiology of youth resilience, the proposed project has the potential to ultimately enhance policy and interventions for youth experiencing neighborhood adversity.

PI_NAMEs: VAZQUEZ, ALEXANDRA YVETTE (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Academic achievement;Adolescence;Area;Attention;Base Sequence;Bioinformatics;Biological;Biological Markers;Biological Process;cell type;Child;Child Development;Childhood;Chronic;community violence;Competence;Confounding Factors (Epidemiology);Consensus;Cross-Sectional Studies;Data;Data Analyses;Data Set;Databases;Development;Developmental Course;Dimensions;Disparate;DNA;DNA Methylation;early adolescence;Early identification;Environment;epigenetic marker;Epigenetic Process;Ethics;Etiology;experience;Exposure to;Failure;Fellowship;Fostering;Genes;Genetic;Goals;Grant;Growth;Heritability;Human;Individual;informant;Intervention;Knowledge;Literature;longitudinal dataset;Manuscripts;Methylation;methylome;methylomics;Michigan;middle childhood;Modeling;Monozygotic twins;National Research Service Awards;neighborhood disadvantage;Neighborhoods;neurogenetics;Organism;Outcome;Pathway interactions;Pattern;Phenotype;Policies;Poverty;predictive marker;Preparation;Process;programs;promote resilience;Psychopathology;Research;Research Personnel;resilience;resilience biomarker;Role;Sampling;sex;skills;social;social skills;Statistical Methods;Stress;stressor;theories;Time;Training;Twin Multiple Birth;Twin Studies;Work;Youth

PROJECT_TITLE: Illuminating the Developmental Etiology of Youth Resilience

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-D(20)L]


NIH_SPENDING_CATS: Digestive Diseases;Nutrition

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE The proposed research is relevant to public health because the discovery of mechanisms by which intestinal epithelial cell physiology adapts to dietary fat is expected to lead to increased understanding of and new treatments for human metabolic diseases. The proposed research is therefore relevant to the part of the NIH’s mission that pertains to developing fundamental new knowledge that will enhance health and reduce the burdens of illness.

PI_NAMEs: MORASH, MARGARET  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: absorption;Acute;Address;Attenuated;Biological Models;Biological Process;blood glucose regulation;burden of illness;Cell Communication;Cell Physiology;Cell secretion;cell type;Cells;Cellular Morphology;Chylomicrons;Classification;Communication;CRISPR/Cas technology;Data;design;Diet;dietary;Dietary Fats;Disease;Endocrine;Endocrine Glands;Enterocytes;Enteroendocrine Cell;Equilibrium;Fatty acid glycerol esters;feeding;Food;Functional disorder;gastrointestinal epithelium;Gastrointestinal Physiology;gene function;Genes;ghrelin;Goals;Health;High Fat Diet;hormonal signals;Hormone secretion;Hormones;Human;Image;improved;in vivo;in vivo imaging;innovation;insight;Intervention;intestinal epithelium;Intestinal Secretions;Intestines;Islets of Langerhans;Knowledge;lipid metabolism;Lipids;Lipolysis;Lipoproteins;Mammals;Mediating;Mentors;Metabolic;Metabolic Diseases;Metabolism;Microbe;Mission;Molecular;Motility;Mus;Mutation;Names;novel;Nutrient;Obesity;Optics;optogenetics;Outcome;particle;pharmacologic;Physicians;Physiological;Physiological Adaptation;Physiology;Population;prevent;Process;Public Health;Reporter;Reporting;Research;Resolution;response;Role;Satiation;Scientist;Sensory;Shapes;Signal Induction;Signal Transduction;single-cell RNA sequencing;Small Intestines;Somatostatin;source localization;Stimulus;Stomach;Testing;therapeutic target;Time;tool;United States National Institutes of Health;Work;Zebrafish

PROJECT_TITLE: Mechanisms of Enteroendocrine Cell Adaptation to High Fat Diet in Zebrafish


NIH_SPENDING_CATS: Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE The obesity epidemic has led to a dramatic increase in morbidity and mortality, with a greater than $190 billion burden annually on American healthcare. There is a need for therapeutic approaches that lessen or eliminate obesity-associated morbidity and mortality with a transformative impact on the American population and healthcare spending. This research effort aims to explore Osteocytic connexin 43 (Ocy Cx43) as a therapeutic target for obesity, by systematically exploring how changes in Ocy Cx43 hemichannel activity leads to local and global changes in adipose tissue formation, ultimately improving whole-body energy expenditure and enhancing systemic metabolic function.

PI_NAMEs: ACOSTA, FRANCISCA MARIA (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Adipocytes;Adipose tissue;Aftercare;Age;American;Antibodies;autocrine;Biological Process;Biomedical Engineering;blood glucose regulation;bone;bone cell;Bone Marrow;Bone remodeling;cancer type;career;career development;Cause of Death;Cell Communication;Cell Survival;Cells;Circulation;combat;Communication;Connexin 43;Connexins;Data;Diabetes Mellitus;Dinoprostone;Disease;Disease Progression;Distant;Dominant-Negative Mutation;Energy Metabolism;Environment;Epidemic;experience;extracellular;Extramedullary;Fatty acid glycerol esters;Global Change;Health;Healthcare;Heart Diseases;Hematopoietic stem cells;Homeostasis;improved;insight;Integral Membrane Protein;Knowledge;Laboratories;Macrophage;Maintenance;mechanotransduction;Mentors;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolism;Monitor;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Myelogenous;Myeloid Cells;new therapeutic target;novel;Obesity;obesity development;Obesity Epidemic;Organ;Osteocytes;Outcome;Paracrine Communication;Physiology;Play;Population;Preparation;Process;Proteins;Regulation;Research;response;Role;Signal Transduction;Site;skills;Source;stem cells;Stroke;Testing;Therapeutic;therapeutic target;Tissue Expansion;Tissues;transdifferentiation;Transgenic Mice;Work;Writing

PROJECT_TITLE: Osteocytic Connexin 43 Hemichannel Regulation of Adiposity


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Chronic Pain;Neurosciences;Pain Research

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Voltage-gated calcium channels play a key role in neurotransmission at both peripheral and central sites of the nervous system. I propose to investigate the importance of these channels at peripheral sites of action in the development of pain and hypersensitivity. I hope to provide insight into potential strategies for mitigating some forms of pain.

PI_NAMEs: MEIR, REMY  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Address;Afferent Neurons;American;Analgesics;Attenuated;Behavior;Behavior assessment;Behavioral;behavioral response;Brain;Calcium;Calcium Channel;Calcium Channel Blockers;Calcium Signaling;Capsaicin;career;Central Nervous System;chronic pain;chronic painful condition;Collaborations;Communication;Computational Technique;Data;delivery vehicle;Dependence;Development;Environment;Event;experience;experimental study;Fellowship;Genetic;Hypersensitivity;Image;Imaging Techniques;improved;in vivo;in vivo calcium imaging;in vivo imaging;Individual;Inflammation;Injury;insight;intercellular communication;interest;Investigation;Knowledge;large datasets;Life;Machine Learning;Maintenance;Measures;Mechanics;Mechanoreceptors;mechanotransduction;Mediating;Methodology;Methods;Modality;mouse model;Mus;Nerve Endings;Nervous System;neurogenetics;Neuroimmune;Neuronal Plasticity;Neurons;neurotransmission;Nociceptors;novel;optogenetics;Output;Pain;pain behavior;Peripheral;Peripheral Nerves;pharmacologic;Pharmacology;Play;Population;prescription opioid;Process;Pythons;Receptor Activation;Research;Resistance;Resources;Role;Science;Scientist;Sensory;Sensory Nerve Endings;Sensory Receptors;sensory stimulus;side effect;Signal Pathway;Signal Transduction;Site;skills;Skin;Speed;Spinal Cord;statistics;Stimulus;Synaptic plasticity;Therapeutic;therapeutic target;Time;tool;Touch sensation;Training;transmission process;two-photon;Universities;Viral Vector;voltage;Work

PROJECT_TITLE: Calcium Signaling in Peripheral Sensory Nerve Endings


NIH_SPENDING_CATS: Bioengineering;Coronaviruses;Data Science;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Pneumonia;Pneumonia and Influenza;Pulmonary Fibrosis

PI_NAMEs: AMARAL, LUIS A. NUNES (contact)

PROJECT_TERMS: 2019-nCoV;Adopted;Award;Biocompatible Materials;Biological Assay;Biological Markers;biomarker identification;Blood;Bronchoalveolar Lavage Fluid;Calcium;Calcium Channel;Cells;Cessation of life;Clinical;Clinical Data;Clinical Decision Support Systems;clinical decision-making;clinical phenotype;cohort;Collaborations;community acquired pneumonia;COVID-19;COVID-19 patient;COVID-19 pneumonia;Critical Illness;Data;Data Set;Dimensions;discrete time;Disease;Dose;Drug Kinetics;Ensure;field study;Generations;Goals;health care settings;Heterogeneity;idiopathic pulmonary fibrosis;Immune response;improved outcome;Infection;inhibitor;Intervention;Machine Learning;machine learning algorithm;Measures;Medicine;Modeling;Molecular;molecular marker;mortality;multidimensional data;Multiomic Data;multiple omics;Nasal Epithelium;Nature;new therapeutic target;Nosocomial pneumonia;novel;novel marker;novel strategies;Outcome;pathogen;Pathogenesis;Patients;Pharmacodynamics;pharmacologic;Phase;Physicians;Physiological;Pneumonia;pneumonia model;pneumonia treatment;post-COVID-19;predictive modeling;Publishing;Pulmonary Fibrosis;randomized trial;Research Personnel;response;Sampling;severe COVID-19;single cell analysis;Space Models;statistical and machine learning;success;System;Systems Biology;targeted treatment;Technology;Testing;Therapeutic Studies;therapeutic target;tool;tool development;transcriptomics;ventilation;Work

PROJECT_TITLE: Modeling Core


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE Successfully increasing cessation rates among African Americans will reduce the racial disparity in mortality among African Americans and Whites by up to 20%. This K01 research proposal outlines, in detail, a plan to develop an evidence-based smartphone intervention for smoking cessation with adjunctive sedentary behavior reduction, which will be culturally tailored for African Americans. Although there are numerous in-person interventions for smoking cessation that have been tailored for African Americans and minorities, smartphone-based interventions are still lacking; thus, this proposal represents an innovative and modern approach for eliminating tobacco-related health disparities in this underserved population.

PI_NAMEs: ALEXANDER, ADAM C (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Abstinence;Accelerometer;Address;African American;African American population;behavior change;Behavior Therapy;Biochemical;Carbon Monoxide;Cellular Phone;contingency management;cost;craving;Data;Development;Discrimination;Ethnic Population;Evaluation;evidence base;Face;facial recognition software;Feedback;Financial Hardship;financial incentive;Future;Goals;Health;Health behavior;Health Disparities Research;health disparity;Hypertension;Image;impression;improved;Individual;individualized medicine;innovation;interest;Intervention;Interview;Measures;Minority;minority health;minority health disparity;Modernization;Monitor;mortality disparity;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;Participant;Persons;Physical activity;Population;portability;Posture;Prevalence;primary outcome;programs;Public Health;Publishing;racial disparity;racial population;Research;Research Proposals;Review Literature;Rewards;Risk Factors;Sampling;Schedule;sedentary;sedentary lifestyle;Self Efficacy;skills;smartphone application;Smoker;Smoking;smoking abstinence;Smoking Behavior;smoking cessation;Smoking Cessation Intervention;smoking prevalence;Smoking Status;Spirituality;Structure;Technology;Testing;Time;Tobacco;tool;Underserved Population;Vulnerable Populations;Work;Wrist

PROJECT_TITLE: HealthyCells: A Culturally-Tailored Smoking Cessation Smartphone Intervention for African Americans with Adjunctive Treatment for Sedentary Behavior


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative Our previous experiences can influence our future choices in many ways, for example by biasing choices towards actions that have been successful in the past (“retrospective decision-making”), or by choosing actions that you think will be successful based on careful mental planning (“inferential decision-making”). Biologically, retrospective decision-making is thought to be mediated by dopamine, though recent work has also suggested a role for dopamine in inferential decision-making. This proposal seeks to describe novel neural circuits that underlie inferential decision-making, the results of which will have applications in neuroscience, psychology, and machine learning.

PI_NAMEs: MAH, ANDREW  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Action Potentials;Address;Animals;Axon;Behavior;Behavioral;Behavioral Model;Brain;Calcium;calcium indicator;Cells;cholinergic;Cognitive;collaborative environment;Computer Models;Corpus striatum structure;Data;Decision Making;design;designer receptors exclusively activated by designer drugs;Development;Dissociation;Dopamine;dopaminergic neuron;Elements;Environment;expectation;experience;experimental study;Fiber;Future;Genetic;Goals;improved;insight;interest;Interneurons;Knowledge;Leadership;Learning;Link;Machine Learning;Maintenance;Measures;Mediating;Mentors;Midbrain structure;Modeling;neural;neural circuit;Neuromodulator;neuronal cell body;neuropsychiatric disorder;Neurosciences;New York;novel;Nucleus Accumbens;Outcome;Pathology;Photometry;Play;Positioning Attribute;Postdoctoral Fellow;Prefrontal Cortex;Presynaptic Terminals;Psyche structure;Psychology;Rattus;Research;reward processing;Rewards;Role;sensor;Signal Transduction;skills;Structure;symposium;System;Techniques;theories;tool;Training;Universities;Viral;Work;Writing

PROJECT_TITLE: Orbitofrontal modulation of dopamine during value-based decision-making


ORG_CITY: Aurora

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE By uncovering molecular mechanisms by which important cytoskeletal proteins assemble into functional units in eukaryotic cells, the proposed research would contribute to fundamental knowledge about the nature and behavior of living systems.

PI_NAMEs: MCMURRAY, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Address;Behavior;Biochemistry;Biology;cell assembly;Cell Differentiation process;Cell Physiology;Cellular biology;Complex;Cytoskeletal Filaments;Cytoskeletal Proteins;Diffusion;Disease;Eukaryotic Cell;Filament;Gametogenesis;Genes;Genetic;Genetic Transcription;Individual;insight;Knowledge;Mediating;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;Mutation;Nature;Organism;Pathway interactions;Phenotype;Positioning Attribute;Property;protein complex;Protein Complex Subunit;Proteins;Research;Rod;Saccharomycetales;Shapes;Specificity;Textbooks;tool;Translating;Translations;Work;Yeasts

PROJECT_TITLE: Mechanisms of septin assembly that shape cellular function

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: The proposed research is directly relevant to public health and NIH’s mission, because our program will result in new functional and mechanistic understanding of immune suppressive mechanisms within tumor microenvironment. This new insight will directly translate into novel immunotherapies for the treatment of cancers.

PI_NAMEs: ZANG, XINGXING  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Address;Ants;Award;Biology;Bladder;cancer immunotherapy;Cancer Patient;cancer therapy;CAR T cell therapy;CD276 gene;CD28 gene;CD80 gene;Cell Physiology;Cells;Clinical;Clinical Research;clinically significant;Colon;Combined Modality Therapy;Copy Number Polymorphism;CTLA4 gene;cytokine;Data;design;Esophagus;Family;Family member;Foundations;Funding;Gene Dosage;Goals;Grant;Homologous Gene;Human;Immune;immune checkpoint;immune checkpoint blockade;Immune Evasion;Immunosuppression;Immunotherapy;improved;innovation;insight;Islet Cell;Kidney;Legal patent;Liver;Lung Transplantation;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of thyroid;Malignant Neoplasms;Melanoma;member;Mission;Molecular;Monoclonal Antibodies;mouse model;neoplastic cell;new therapeutic target;novel;Outcome;Ovary;overexpression;Pancreas;Pathway interactions;PD-1/PD-L1;Phylogenetic Analysis;programmed cell death ligand 1;programmed cell death protein 1;programs;Prostate;Proteins;Public Health;Publications;receptor;Renal Carcinoma;Research;Skin;Structure;T-Lymphocyte;targeted treatment;Testing;Therapeutic;tool;Transgenic Mice;Translating;Treatment Efficacy;Trees;tumor;Tumor Immunity;tumor microenvironment;tumorigenesis;United States National Institutes of Health;VTCN1 gene

PROJECT_TITLE: The B7x pathways in the tumor microenvironment

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Microbiome;Pneumonia;Pneumonia and Influenza

PROJECT_TERMS: 2019-nCoV;Biological Markers;Biological Models;Blood specimen;Bronchoalveolar Lavage;Calcium;Caring;cell type;Cells;climate change;Clinical;Clinical Data;clinical predictors;Clinical Trials;Collaborations;community acquired pneumonia;Controlled Clinical Trials;COVID-19 pneumonia;COVID-19 treatment;Curettage procedure;cytokine;Data;Data Scientist;Data Set;disease model;Disparate;Distal;Electronic Health Record;emerging pathogen;Enrollment;Epidemic;epigenomics;experimental study;Foundations;Frequencies;genomic data;Hospital complications;Hospitalization;Hospitals;Immune response;improved;Infection;Influenza A virus;inhibitor;insight;Intervention;Lung;lung microbiome;Machine Learning;Mechanical ventilation;microbiome analysis;Middle East Respiratory Syndrome Coronavirus;Modality;Modeling;Molecular;Molecular Profiling;mortality;mouse model;Multiomic Data;multiple omics;Nasopharynx;Nose;Nosocomial pneumonia;novel;novel therapeutics;Outcome;pandemic disease;pandemic potential;pathogen;pathogen genomics;Pathogenesis;Pathway interactions;Patients;pharmacologic;Phase II Clinical Trials;phase II trial;Phenotype;Pneumonia;pneumonia model;pneumonia treatment;Population;Prediction of Response to Therapy;Process;prospective;Proteomics;prototype;Public Health;Publishing;Research Infrastructure;Research Personnel;respiratory;response;Sampling;SARS coronavirus;SARS-CoV-2 pathogenesis;Secondary to;Serum;severe COVID-19;single-cell RNA sequencing;Space Models;specific biomarkers;Steroids;Systems Biology;T-Lymphocyte;targeted treatment;Testing;Therapeutic;tocilizumab;tool;Translating;treatment response;Update;Variant;Viral;Virus;Zoonoses

PROJECT_TITLE: Systems Biology Modeling of Severe Community-Acquired Pneumonia


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Muscular Dystrophy;Myotonic Dystrophy;Neurosciences;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: PATHOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The pathological consequences of myotonic dystrophy type 1 (DM1) are understudied in the visceral smooth muscle of the gastrointestinal tract despite a high prevalence of gastrointestinal disturbances in affected individuals. This proposal focuses on the impact of muscleblind-like (MBNL) loss of activity, a primary mechanism of DM1 pathology, on gastrointestinal motility. The studies proposed in this fellowship will elucidate both physiological and molecular impacts of MBNL loss on smooth muscle, providing novel insight on the myogenic mechanisms of DM1 gastrointestinal pathology and potential avenues for therapeutic study.

PI_NAMEs: PETERSON, JANEL ANN MERKEL (contact)

PROJECT_TERMS: 3' Untranslated Regions;Adult;Affect;affective disturbance;Affinity;Alleles;Alternative Splicing;Anatomy;Area;Atrophic;autosome;Binding Sites;Biological Assay;Blood Pressure;Blood Vessels;Brain;Calcium;Calcium Channel;Cardiopulmonary;Cell Line;Clinical Research;Cognitive;Colorectal;Complex;Constipation;Data;Defect;Deglutition;Development;differential expression;Disease;Embryo;Esophagus;Evaluation;Event;Exhibits;Family;Feces;Fellowship;Fetal Proteins;fluorescein isothiocyanate dextran;Frequencies;Functional disorder;gain of function;gastrointestinal;Gastrointestinal Motility;gastrointestinal system;Gastrointestinal tract structure;Gastrointestinal Transit;Genes;Genetic Transcription;Goals;Heart;High Prevalence;Histologic;Human;Hyperplasia;In Vitro;Individual;insight;Intestines;Investigation;knock-down;Knock-out;Knockout Mice;Large Intestine;Life;live cell imaging;loss of function;LoxP-flanked allele;Maps;Measurement;Measures;Messenger RNA;Modeling;Molecular;Motility;motility disorder;mouse model;Movement;mRNA Stability;Mus;Muscle;Muscle Contraction;Muscle function;Muscle Tonus;Muscle Weakness;Muscular Dystrophies;Myocardium;Myotonia;Myotonic Dystrophy;Myotonic dystrophy type 1;novel;Nutrient;Obstruction;Ontology;Oral;paralogous gene;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Pattern;Periodicity;Personal Satisfaction;Phenotype;Physiological;Polyadenylation;postnatal;prevent;Protein Family;Protein Isoforms;Protein Kinase;Proteins;Regulation;release of sequestered calcium ion into cytoplasm;Research;Reverse Transcriptase Polymerase Chain Reaction;RNA;RNA Interference;RNA Processing;RNA Splicing;RNA-Binding Proteins;Role;RyR1;Severities;Skeletal Muscle;skeletal muscle wasting;Smooth Muscle;Smooth Muscle Myocytes;spatiotemporal;Spliced Genes;Structure;Surveys;Symptoms;Tamoxifen;Therapeutic Studies;Thick;Time;Tissue Sample;Tissue-Specific Gene Expression;Tissues;transcriptome sequencing;transcriptomics;Trinucleotide Repeat Expansion;uptake;Vascular Smooth Muscle;Visceral;Water

PROJECT_TITLE: MBNL loss of function in visceral smooth muscle as a model of myotonic dystrophy type 1


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: AMHERST

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PI_NAMEs: DUBOCOVICH, MARGARITA L (contact)

PROGRAM_OFFICER_NAME: CONROY, JENNIE LYNN

PROJECT_TERMS: Acceleration;Address;Area;Award;Awareness;career;career development;Clinical;Clinical Investigator;Clinical Research;Clinical Sciences;Collaborations;Communication;Communities;Competence;Credentialing;digital;Discipline;Disease;Doctor of Pharmacy;Doctor of Philosophy;Documentation;Educational Curriculum;Ethnic Origin;Evaluation;experience;Faculty;Funding;Goals;health disparity;Health Sciences;Individual;innovation;Institution;Interdisciplinary Education;K-Series Research Career Programs;Learning;Link;Mentors;next generation;novel diagnostics;Pathway interactions;Physicians;preventive intervention;programs;Race;Scholars Program;Scientist;skills;Talents;Therapeutic Intervention;Training;Training Programs;Translational Research;translational scientist

PROJECT_TITLE: Institutional Career Development


ORG_CITY: MEMPHIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MEMPHIS

ORG_STATE: TN

PHR: Primary Investigator: Kumar, Santosh mHealth Center for Discovery, Optimization & Translation of Temporally-Precise Interventions (mDOT) – Overall Public Health Relevance: Modifiable behavioral and contextual risk factors are known to be the major determinant of most disease outcomes. Maximizing the efficacy of such mHealth interventions through mDOT technologies can transformatively improve health and disease outcomes by enabling patients to initiate and sustain the healthy lifestyle choices necessary to prevent and/or successfully manage the growing burden of multiple chronic conditions. 2

PI_NAMEs: KUMAR, SANTOSH  (contact)

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Academia;Algorithms;Architecture;Awareness;Behavior;Behavioral;Big Data;Biological Markers;burden of chronic illness;burden of illness;Cellular Phone;Chronic Disease;Clinical;Collaborations;Communities;Companions;Complex;Computer software;Data;Data Security;Data Sources;data streams;design;Development;Digital biomarker;digital intervention;Disease;Disease Outcome;Ensure;Environment;Evaluation;Explosion;field study;Goals;Health;Health behavior;Health Benefit;Health Promotion;Healthcare;healthy lifestyle;improved;Individual;Industry;Infrastructure;innovation;Intervention;intervention delivery;Joints;Knowledge;Learning;learning strategy;Life;Link;Location;Medical;Mentors;Methodology;Methods;mHealth;mhealth interventions;mobile computing;mobile sensor;Modeling;Monitor;multimodality;multiple chronic conditions;next generation;novel;open source;Outcome;Patient Care;Patients;personalized intervention;Persons;physical inactivity;Population;Positioning Attribute;preference;prevent;Preventive;Privacy;Procedures;Productivity;Psychological reinforcement;public health relevance;Research;Research Personnel;Resources;Risk;Risk Factors;Self Care;sensor;sensor technology;Series;Services;Sleep;Smoking;software infrastructure;Structure;System;technological innovation;Technology;technology research and development;technology training;Time;tool;Training;Training Programs;Translations;Treatment Efficacy;Uncertainty;Unhealthy Diet;uptake;usability;Vision;wearable device;Work

PROJECT_TITLE: mHealth Center for Discovery, Optimization, and Translation of Temporally-Precise Interventions (mDOT)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: Project Narrative Due to increases in human lifespan, Alzheimer’s disease is rapidly becoming a public health crisis. This study will explore the role of antigen-specific T cells in Alzheimer’s, with the goal of identifying novel disease mechanisms and potential therapeutic targets for this devastating disease.

PI_NAMEs: GATE, DAVID  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: adaptive immune response;Affect;Age;age related;age related neurodegeneration;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer’s disease biomarker;Amyloid beta-Protein;antigen-specific T cells;Antigens;Area;Autoimmune Responses;Autologous;Automobile Driving;Award;Binding;Biological Assay;Biological Markers;Blood;Brain;BZLF1 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;cell killing;Cell Line;Cells;Cellular biology;Cerebrospinal Fluid;Chronic;Circulation;Clonal Expansion;Clone Cells;Cloning;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Collaborations;cytokine;cytotoxic;Data;Deep Cervical Lymph Node;Disease;effector T cell;environmental enrichment for laboratory animals;experience;experimental study;Extravasation;Fellowship;Fibroblasts;Genes;genome editing;Germ Cells;Goals;Hematological Disease;Human;Human Herpesvirus 4;Immune;Immune response;Induced Neurons;Inflammation;Inflammatory;Intrathecal Space;Knock-out;Knowledge;Libraries;life span;Liquid substance;Measures;Mediating;Memory;Meningeal lymphatic system;Meninges;Mentors;Methods;Molecular;Nerve Degeneration;Neurodegenerative Disorders;neuroimmunology;neuroinflammation;neuron loss;Neurons;new therapeutic target;next generation sequencing;novel;novel marker;Pathologic;Patients;Peptide Receptor;Peptides;Peripheral;Phase;Play;Population;Process;Proteins;Public Health;rab GTP-Binding Proteins;Research;Research Personnel;resilience;response;Role;screening;Severity of illness;single-cell RNA sequencing;Site;Specificity;Statistical Methods;statistics;Structure of choroid plexus;Subarachnoid Space;T cell clonality;T cell receptor repertoire sequencing;T-Cell Receptor;T-Lymphocyte;tau Proteins;Testing;theories;therapeutic biomarker;therapeutic target;Training;transcription factor;transcriptomics;Universities;Yeasts

PROJECT_TITLE: A novel blood-CSF adaptive immune response in Alzheimer's disease

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Networking and Information Technology R&D (NITRD);Prevention;Telehealth

PHR: Principal Investigator: Kumar, Santosh mDOT – Administration Core Public Health Relevance: mDOT will equip the transdisciplinary mHealth research community with mDOT technologies and methods to discover, optimize, and deploy temporally-precise mHealth interventions. Adoption of mDOT technologies will give rise to a new research paradigm and precipitate a much-needed transformation in healthcare by enabling patients to initiate and sustain the healthy lifestyle choices necessary to prevent and/or successfully manage the growing burden of multiple chronic conditions. 2

PROJECT_TERMS: Adoption;Advisory Committees;Biomedical Research;biopsychosocial;burden of chronic illness;Businesses;Cellular Phone;Collaborations;Communication;Communities;Companions;data management;data to knowledge;Development;Engineering;Ensure;experience;Feedback;Funding;Geography;Goals;Health;Healthcare;healthy lifestyle;improved;Individual;Infrastructure;Institution;Intervention;Lead;Leadership;Marketing;Measurable;Measures;Medical;Medicine;member;Methods;mHealth;mhealth interventions;mobile sensor;Monitor;multidisciplinary;multiple chronic conditions;Nature;open source;operation;organizational structure;Outcome;outreach;Patients;Policies;Postdoctoral Fellow;prevent;Principal Investigator;Procedures;Productivity;programs;public health relevance;Qualifying;recruit;Research;Research Personnel;Research Project Grants;Resources;Role;Running;Science;Scientist;Secure;Services;software development;Software Engineering;Structure;Students;success;System;technological innovation;Technology;technology research and development;tool;Training;Translations;United States National Institutes of Health;Universities;virtual;wearable device;Work

PROJECT_TITLE: mDOT Administrative Core


NIH_SPENDING_CATS: Cancer;Complementary and Integrative Health;Dietary Supplements;Genetics;Nutrition;Obesity;Prevention

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Data from this study are expected to establish E-FABP as a novel molecular sensor mediating n-3 FA-induced anti-tumor effects. This proposal will not only have basic science ramifications for understanding molecular mechanisms by which n-3 FAs epigenetically enhance immune cell differentiation, but will also have significant translational implications for the role of healthy diets in cancer prevention.

PI_NAMEs: LI, BING  (contact)

PROGRAM_OFFICER_NAME: EMENAKER, NANCY J

PROJECT_TERMS: Address;aldehyde dehydrogenase 1;Animals;antitumor effect;Basic Science;cancer prevention;cancer risk;cancer therapy;carcinogenesis;CD8B1 gene;Cell Differentiation process;Cell Physiology;Cells;Clinical;Clinical Trials;cocoa butter;conditional knockout;Confusion;Consumption;Custom;Data;demethylation;Development;Diet;dietary;Dietary Factors;Dietary Fatty Acid;dietary supplements;DNA;DNA methyltransferase inhibition;dosage;Epigenetic Process;Epithelial Cells;Epithelium;Exhibits;Experimental Designs;Fatty acid glycerol esters;fatty acid-binding proteins;Fish Oils;Funding;good diet;Growth;Health;High Fat Diet;Human;Immune;Immunity;Immunologic Surveillance;Immunophenotyping;improved;In Vitro;in vivo;insight;Interferons;Knockout Mice;Knowledge;Life Style;Linoleic Acids;Malignant Neoplasms;Mediating;Metabolic;Modeling;Molecular;Morbidity - disease rate;mortality risk;mouse model;Mus;neoplastic cell;Non obese;novel;Obese Mice;Obesity;Oleic Acids;Olive oil preparation;Omega-3 Fatty Acids;Persons;Play;Population;preclinical study;prevent;Prevention;Production;protein expression;Reactive Oxygen Species;response;Role;Safflower Oil;Saturated Fatty Acids;sensor;Signal Transduction;STAT3 gene;T cell differentiation;T-Lymphocyte;Therapeutic;Toxic effect;tumor;tumor growth;Tumor-Derived;Tumor-infiltrating immune cells;Vitamin D;World Health Organization;γδ T cells

PROJECT_TITLE: E-FABP mediates n-3 fatty acid-induced tumor prevention through epigenetic control of immune cell differentiation and function

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Cancer Genomics;Complementary and Integrative Health;Dietary Supplements;Genetics;Human Genome;Natural Products;Nutrition;Prevention;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Public Health Relevance Statement: Estrogen receptor-negative breast cancer is too often fatal and there is a strong need to prevent this disease before it becomes recalcitrant to conventional cancer therapy. An important field-driving and novel goal of this application is to develop dietary combinations of green tea polyphenols and sulforaphane-rich broccoli sprouts that can be safely consumed to reduce estrogen receptor-negative breast cancer risk and severity in offspring generations even when consumed by either of their parents before conception of the offspring.

PI_NAMEs: TOLLEFSBOL, TRYGVE O (contact)

PROGRAM_OFFICER_NAME: RISCUTA, GABRIELA

PROJECT_TERMS: Affect;Automobile Driving;Breast Cancer Prevention;Breast Cancer Risk Factor;Broccoli - dietary;cancer initiation;cancer prevention;cancer therapy;Chemoprevention;combinatorial;Conceptions;Consumption;Data;Diet;dietary;dietary approach;dietary control;Disease;DNA methyltransferase inhibition;DNA Modification Methylases;efficacious treatment;Epigallocatechin Gallate;Epigenetic Process;epigenome;epigenomics;Estrogen decline;Estrogen receptor negative;Fathers;Female;Fetus;Gene Expression;Generations;Genes;Germ Cells;Goals;Growth;Histone Deacetylase;Histone Deacetylase Inhibitor;innovation;Investigation;Life;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Mothers;Mus;novel;novel strategies;offspring;Parents;Placenta;prevent;Prevention;Preventive;Process;promoter;public health relevance;Regimen;Risk;Risk Reduction;Severities;Solid;Statistical Data Interpretation;success;Sulforaphane;Time;Toxic effect;transgenerational epigenetic inheritance;translational potential;tumor;tumor growth;Tumor Suppression;Woman

PROJECT_TITLE: Combinatorial epigenetic-based prevention of breast cancer


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE The ability to maintain relevant information necessary to make decisions and continuously update our autobiographies as we amass experience from childhood into adulthood depends on the medial temporal lobe and prefrontal cortex. By measuring electrical activity directly from the human brain, the proposed research will determine the mechanisms by which these regions interact to form and maintain memories in real time, and identify sources of developmental variability in these mechanisms from childhood into adulthood. The outcomes will increase understanding of how the brain implements normal memory and how brain circuits may go awry in disordered behavior, laying the foundation for translational work aimed at improving memory in populations suffering from disease or injury.

PI_NAMEs: JOHNSON, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Adolescent;Adult;Age;age related;age related decline;aged;Aging;aging population;Alzheimer's Disease;Animals;Autobiography;Behavior;Behavior Disorders;behavior prediction;Behavioral;Behavioral Model;Brain;career;career development;Child;Childhood;Clinical;Cognition;comparative;Data;Data Analyses;Decision Making;Dementia;Deterioration;Development;Development Plans;Disease;Electroencephalography;Electrophysiology (science);Equilibrium;Ethics;experience;flexibility;Foundations;Frequencies;frontal lobe;Future;Future Teacher;Goals;Health;Hippocampus;Human;Human Activities;human model;improved;indexing;Individual;Individual Differences;Injury;Knowledge;Laboratories;Life;life span;Link;Maintenance;Maps;Measures;Medial;medial temporal lobe;Memory;Memory Loss;Mentors;Mentorship;Nervous System Disorder;neural;neural circuit;neural network;Neurocognitive;Neurologic;neuromechanism;Neurons;neurophysiology;Neurophysiology - biologic function;neuropsychiatric disorder;Neurosciences;neurosurgery;Noise;nonhuman primate;novel;Outcome;Patients;Pattern;Performance;Phase;Physiology;Population;Positioning Attribute;Predisposition;Prefrontal Cortex;Principal Investigator;programs;Reporting;Research;Research Personnel;responsible research conduct;Role;Running;Scalp structure;Seizures;Series;Short-Term Memory;Signal Transduction;skills;Source;spatiotemporal;statistics;Stroke;Structure;Study models;success;System;Theta Rhythm;Time;Training;Traumatic Brain Injury;Update;Work

PROJECT_TITLE: Measuring Electrical Activity from the Human Brain to Predict Memory Formation and Behavior Across the Lifespan


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Lung;Microbiome;Patient Safety;Pneumonia;Pneumonia and Influenza

PI_NAMEs: HAUSER, ALAN R (contact)

PROJECT_TERMS: Age;Antibiotics;Bacteria;biobank;Biological Assay;biomarker identification;biosignature;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Clinical;clinical predictors;cohort;Communities;community acquired pneumonia;Complication;Computer Models;cytokine;Data;Death Rate;Dedications;Deterioration;Development;Disease;Disease Outcome;Enrollment;Failure;Flow Cytometry;Funding;Future;Genetic;Genome;Goals;Hospitalization;Hospitals;humanized mouse;Immune response;Immunosuppression;improved;Infection;Inflammatory Response;insight;Intervention;Intervention Studies;Klebsiella;Knowledge;Lung;lung microbiome;Mechanical ventilation;Metadata;metagenomic sequencing;microbiome;microbiota;Modeling;Morbidity - disease rate;mortality;mouse model;Multi-Drug Resistance;Multiomic Data;multiple omics;Nosocomial pneumonia;novel;novel therapeutic intervention;Outcome;outcome prediction;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Patient-Focused Outcomes;Patients;Pattern;Pneumonia;pneumonia model;pneumonia treatment;predict clinical outcome;predictive modeling;predictive test;Pseudomonas aeruginosa;Research;Research Project Grants;Resources;Respiratory Failure;response;Ribosomal RNA;Sampling;Shotguns;single-cell RNA sequencing;Staphylococcus aureus;Systems Biology;Techniques;Testing;Therapeutic Intervention;transcriptome;transcriptomics;Unfavorable Clinical Outcome;Validation;ventilator-associated pneumonia;Work

PROJECT_TITLE: Systems Biology Modeling of Severe Hospital-Acquired Pneumonia


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Activity;Prevention;Telehealth

PHR: Project Lead: Rehg, Jim Primary Investigator: Kumar, Santosh TR&D1: Enabling the Discovery of Temporally-Precise Intervention Targets and Timing Triggers from  mHealth Biomarkers via Uncertainty-Aware Modeling of Personalized Risk Dynamics  Lead: Dr. Jim Rehg, Georgia Tech; 10% effort (0.9 CM) Public Health Relevance: TR&D1 will enable the identification of momentary risk factors and risk dynamics from mHealth biomarkers that drive adverse health outcomes, while accounting for the uncertainty and missingness inherent in real-life mHealth data. TR&D1 will enable the improved understanding of chronic disease progression, and increase the robustness, personalization and temporal precision of mHealth interventions, thereby boosting the potential for mHealth interventions to significantly improve treatment efficacy and enhance the success of long-term health behavior change and maintenance. 2

PI_NAMEs: REHG, JAMES M. (contact)

PROJECT_TERMS: adaptive intervention;Address;Adverse event;Architecture;Area;Awareness;Behavior;Biological Markers;biopsychosocial;Budgets;burden of chronic illness;Cellular Phone;Chronic Disease;cigarette smoking;cloud based;Collection;Communities;Companions;Complement;Complex;Computer software;craving;Data;Data Analyses;data imputation;data modalities;data modeling;Data Sources;Decision Making;design;Development;Devices;Disease Progression;Dropout;Effectiveness;Ensure;Event;Exercise;Fatigue;Feedback;field study;forgetting;Generations;Graph;Health;Health behavior change;Healthcare;healthy lifestyle;improved;Individual;Infrastructure;interest;Intervention;Investigation;Knowledge;Lead;Learning;learning strategy;Length;Life;machine learning method;Maintenance;Measures;Medical;Medicine;Metadata;Methods;mHealth;mhealth interventions;mobile sensor;Modeling;Moods;multimodality;Nature;neural network;Neural Network Simulation;Non-linear Models;novel;open source;Outcome;Participant;patient engagement;Patients;Pattern;personalized learning;Physical activity;Population;prevent;Privacy;Process;Psychological reinforcement;public health relevance;recurrent neural network;Research;Research Personnel;Resources;Risk;Risk Assessment;Risk Factors;Running;sedentary lifestyle;sensor;Series;Services;Sleep;Smoking;Stress;success;synergism;System;technological innovation;Technology;technology research and development;therapy design;Time;tool;Training;Translations;Treatment Efficacy;Uncertainty;usability;wearable device;wireless;Work

PROJECT_TITLE: mDOT TR&D1 (Discovery) - Enabling the Discovery of Temporally-Precise Intervention Targets and Timing Triggers from mHealth Biomarkers via Uncertainty-Aware Modeling of Personalized Risk Dynamics


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Relevance Neurofibromatosis type 1 (NF1) is a genetic disorder that predisposes affected individuals to tumors of the nervous system, and other disease manifestations. We will use the state-of-the art interdisciplinary approaches to study the role of NF1 interaction partners, including RAS paralogs, in Schwann cell proliferation, survival, and tumorigenesis, to define binding partners and vulnerabilities in NF1 mutant cells relevant to neurofibromas.

PI_NAMEs: RATNER, NANCY  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Affect;Agonist;Alleles;Arginine;Binding;Biochemical;Biochemistry;Biotinylation;Cancer Model;Cell Proliferation;Cell Survival;cell type;Cells;Cessation of life;Characteristics;Complex;Data;Development;Disease;Family;Fingers;gain of function;Genetic;Genetic Diseases;Goals;Growth;Growth Factor;Guanosine Triphosphate Phosphohydrolases;Heritability;Histology;Homeostasis;immunocytochemistry;Immunohistochemistry;In Vitro;in vivo;Individual;inhibitor;interdisciplinary approach;KRAS2 gene;Location;loss of function;Magnetic Resonance Imaging;Mammals;Maps;Mediating;member;Metabolic;Methods;Modeling;Molecular Biology Techniques;Molecular Chaperones;Monomeric GTP-Binding Proteins;mouse genetics;mouse model;Mus;mutant;neoplastic cell;Nervous System Neoplasms;neurofibroma;Neurofibromatosis 1;NF1 gene;novel;Oncogenic;Oral;paralogous gene;Pathway interactions;Patients;Peripheral Nerves;Peroxidases;pharmacologic;Phosphorylation;Phosphorylation Site;Preclinical Testing;Predisposition;Proliferating;Property;Prostatic Neoplasms;prostratin;protein complex;Proteins;ras Proteins;Reagent;response;Role;Schwann Cells;self-renewal;sensor;sermons;Signal Pathway;Signal Transduction;Survival Analysis;Syndrome;Tamoxifen;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;Time;tumor;Tumor Suppressor Proteins;tumorigenesis;Western Blotting

PROJECT_TITLE: Identification of Novel Pathways Causing NF1-Driven Schwann Cell Tumors

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: NARRATIVE We propose to develop a simple microscopy technique to obtain comprehensive, video-rate, multiplane fluorescence imaging in brain tissue over volumes 1×1×1mm3. Such fast volumetric imaging over such large scales, particularly in depth, is unprecedented, and will be impactful in neuroscience research.

PI_NAMEs: MERTZ, JEROME  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: 3-Dimensional;Area;Biology;Brain;Brain imaging;brain tissue;Calcium;calcium indicator;cell type;Color;Communities;Detection;Development;Effectiveness;Electronics;Environment;experimental study;fluorescence imaging;Goals;high resolution imaging;Image;improved;in vivo calcium imaging;Lasers;Letters;Light;Lighting;Microscope;Microscopy;millimeter;Monitor;multiphoton microscopy;Mus;Neocortex;neuroimaging;Neurons;Neurosciences Research;new technology;olfactory bulb;optical imaging;Penetration;Performance;photonics;Physiologic pulse;Population;preservation;prototype;Reporting;Resolution;Sampling;Scanning;Series;Source;Speed;Surface;System;Techniques;Technology;Thick;three photon microscopy;tool;tool development;two-photon

PROJECT_TITLE: Multi-Layer Neuronal Imaging with Reverberation Multiphoton Microscopy

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Due to neurovascular coupling, neural activity creates a reliable increase in blood flow and hence local temperature, which can be measured in the operating room with an infrared thermographic camera. While an awake patient performs tasks, this new method of monitoring the patterns of temperature fluctuation can be used to create a map of brain function, that once validated the surgical team can use to avoid damage to key functional areas. This can lead to safer, faster, and more effective surgeries for patients with drug-resistant epilepsy, glioma, or neurovascular malformations.

PI_NAMEs: PARRISH, TODD B (contact);TATE, MATTHEW CHRISTOPHER

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;Adult;Agreement;Algorithms;Anatomy;Area;arm;Articulation;Attention;Auditory;awake;Behavioral;Blood;Blood flow;blood oxygen level dependent;Blood Vessels;Brain;brain based;Brain imaging;Brain Mapping;Brain region;Cerebral cortex;Clinical;Cognitive;Complex;Computer software;Computers;Contralateral;contrast imaging;Craniotomy;Data;Data Display;data quality;data streams;Devices;diagnostic accuracy;Diffuse;electric field;Electric Stimulation;Electrodes;Epilepsy;Esthesia;Excision;Exposure to;Fingers;Functional Imaging;Functional Magnetic Resonance Imaging;Future;Glioma;Goals;haptics;hemodynamics;High temperature of physical object;Image;imaging system;improved;Individual;Infiltration;Intractable Epilepsy;Language;Lesion;malformation;Malignant neoplasm of brain;Maps;Measures;Memory;Metabolic;Metabolism;Methodology;Methods;microphone;Modeling;Monitor;Morbidity - disease rate;Motion;Motor;Motor Cortex;multitask;neural;Neurologic;Neurologic Deficit;Neuronavigation;neurosurgery;neurovascular;neurovascular coupling;novel;Operating Rooms;Operative Surgical Procedures;Patient-Focused Outcomes;Patients;Pattern;Perfusion;Physiological;Postoperative Period;predictive modeling;prevent;Procedures;Process;Property;Protocols documentation;quality assurance;Quality of life;Records;Research;Resolution;response;Risk;Role;Safety;Seizures;Sensitivity and Specificity;Sensory;Signal Transduction;source localization;spatiotemporal;Speech;speech recognition;Stimulus;success;Surface;synergism;System;Techniques;Technology;Temperature;Testing;Thermodynamics;Thermography;Time;Tissues;tumor;Vision;wireless

PROJECT_TITLE: High-resolution Infrared Thermal Imaging (ITI) for Simultaneous Functional Mapping of the Entire Craniotomy in Awake Patients

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]