ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Burden of Illness;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHESTNUT HILL

ORG_DEPT: BIOLOGY

ORG_NAME: BOSTON COLLEGE

PHR: PROJECT NARRATIVE While 1 in 4 Americans with diabetes who require insulin therapy ration their insulin to save money, emerging adults with type 1 diabetes report even higher rates of cost related non-adherence and experience worse glycemic outcomes. The goals of this career development project are to understand objective financial burden and subjective financial distress, as well as associations with social determinants of health, cost-coping behaviors, health insurance access, and glycemic outcomes in emerging adults with T1D, leading to the development and pilot testing of a psychoeducational intervention to reduce financial toxicity and cost related non-adherence. This research will advance the understanding of financial toxicity in diabetes and support Dr. Katherine Wentzell on her trajectory towards becoming an independent clinical investigator.

PI_NAMEs: WENTZELL, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: Acceleration;acceptability and feasibility;Acute;Adult;Age;age group;American;anti-cancer research;Area;Attitude;Behavioral Research;Belief;career;career development;Cessation of life;Chronic;Clinical;Clinical Investigator;Clinical Research;comparison intervention;Coping Behavior;cost;Dangerous Behavior;Dangerousness;Development;diabetes distress;diabetes management;Diabetes Mellitus;diabetes self-management;Diabetic Ketoacidosis;Doctor of Philosophy;emerging adult;experience;Family;Financial cost;Financial Hardship;financial toxicity;Focus Groups;Frequencies;Geography;glycemic control;Goals;Health Care Costs;Health Insurance;Healthcare;healthcare burden;improved;improved outcome;innovation;Insulin;Insulin-Dependent Diabetes Mellitus;Insurance Coverage;interest;Intervention;Intervention Studies;Interview;K-Series Research Career Programs;life span;Literature;Malignant Neoplasms;Measures;Medical;Mental Health;Mentorship;Methodology;Methods;Morbidity - disease rate;mortality;multidisciplinary;Names;Nurse Practitioners;Outcome;Participant;Patient Self-Report;Pediatric Nursing;Persons;pilot test;Postdoctoral Fellow;Poverty;premature;psychoeducational intervention;Psychological Factors;psychosocial outcome;Randomized, Controlled Trials;Recommendation;recruit;Registries;Reporting;Research;Research Methodology;Research Personnel;Risk;routine care;Sampling;satisfaction;skills;social health determinants;social media;stressor;Structure;Surveys;Text;therapy development;Time;tool;trend;Unemployment;Work;young adult

PROJECT_TITLE: Investigating the Impact of Financial Toxicity in Young Adults with T1D

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Brain Disorders;Clinical Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

ORG_CITY: FORT COLLINS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_FIPS: US

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Narrative This Supplement project aims to identify molecular markers of risk for autism spectrum disorder (ASD) in young children with Down syndrome (DS) to advance early screening procedures. We will leverage the ASD-related phenotyping data collected in project #R01HD110542 and collect blood samples concurrently with ASD assessment visits. The addition of biospecimen collection to parent project data collection could facilitate the discovery of molecular indicators of ASD in DS and advance early detection of DS+ASD. It could also identify potential mechanisms that contribute to the onset of DS+ASD and contribute to a new scientific foundation for early intervention and future treatments in this population.

PI_NAMEs: ESPINOSA, JOAQUIN M.;FIDLER, DEBORAH J (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: 1 year old;Address;Administrative Supplement;Area;autism spectrum disorder;autism symptoms;Biological Markers;biomarker identification;biosignature;Blood specimen;care costs;Child;Clinical;clinical care;cohort;Collection;cytokine;Data;Data Collection;Data Coordinating Center;Databases;design;Detection;Development;Dimensions;disorder risk;Down's Syndrome;Early Diagnosis;Early identification;Early Intervention;early screening;Foundations;Future;Goals;Health;improved;Individual;information gathering;innovation;Intellectual functioning disability;Interferons;Intervention;Investigation;knowledge base;Leukocytes;life span;Linear Regressions;Link;Measurable;Medical;metabolome;metabolomics;model of autism spectrum disorder;Modeling;Molecular;molecular marker;Molecular Profiling;Monitor;multiple omics;Nature;neurogenetics;Outcome;parent project;Parents;Participant;Performance;Personal Satisfaction;Phenotype;phenotypic data;Plasma;Population;Preventive;Process;Prospective Studies;Proteome;Proteomics;Quality of life;Recording of previous events;recruit;resilience;response;Risk;Risk Marker;Science;Scientific Advances and Accomplishments;Screening procedure;sex;Site;Specificity;Testing;tool;transcriptome;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Admin supplement - Autism in young children with Down Syndrome

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: AG

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Microbiome;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: MADISON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Public Health Relevance/Narrative: Alzheimer's Disease (AD) and AD Related Dementias (ADRD) are among the most prevalent and impactful diseases in the United States and throughout the world and currently there no effective treatments or therapeutics that slow or stop disease. This project seeks to determine whether a metabolite derived from the gut bacteria, which is generated from the breakdown of the dietary amino acid histidine, has negative effects on the vasculature and can modify the pathogenesis of AD. The proposed work will generate new information that can potentially inform the development of new therapeutic strategies for prevention or treatment of AD/ADRD.

PI_NAMEs: BENDLIN, BARBARA BRIGITTA;REY, FEDERICO E (contact);ULLAND, TYLER KENT

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Acceleration;Affect;Age;Age Months;aging population;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amines;Amino Acids;Amyloid beta-Protein;Animals;APP-PS1;Bacteria;bacterial community;Biological Markers;Biology;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Platelets;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;blood-brain barrier permeabilization;Brain;brain endothelial cell;Brain Pathology;burden of illness;Cardiovascular Diseases;Cell Aging;Cell Line;Cell Physiology;cell type;Cerebrospinal Fluid;cerebrovascular;Circulation;Clinical;Complex;Controlled Environment;Coronary Arteriosclerosis;Data;Dementia;dementia risk;Development;Diet;dietary;Disease;disease model;Disease Progression;Distant;drinking water;effective therapy;Endothelial Cells;endothelial dysfunction;Epidemiology;Etiology;executive function;Exposure to;extracellular;fecal transplantation;Female;Functional disorder;Germ-Free;Gnotobiotic;gut bacteria;gut microbes;gut microbiome;gut microbiota;Health;Histidine;Homeostasis;host microbiota;Human;human old age (65+);Hypertension;Imidazole;Impaired cognition;Impaired wound healing;Impairment;In Vitro;in vivo;Incidence;Indican;Individual;Inflammation;Inflammatory Response;Infrastructure;Light;Link;Liquid substance;Magnetic Resonance Imaging;male;Measures;Mediating;microbial;Microbiology;microbiome;Modeling;Molecular;monolayer;Morphology;mouse model;Mus;Nerve Degeneration;nerve injury;Neurodegenerative Disorders;neurofilament;neuroimmunology;neurotoxic;neurovascular;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;obese patients;Onset of illness;Organ;Overweight;Oxides;Participant;Pathogenesis;Pathologic;Pathology;Pathway interactions;Performance;Permeability;Persons;Phenotype;Physiology;Plasma;Play;Positioning Attribute;pre-clinical;Pre-Clinical Model;Prevention strategy;Production;Propionates;protein expression;Proteins;public health relevance;receptor;repaired;Reporting;Research;Risk Factors;Risk Reduction;Role;Sampling;Senile Plaques;Shapes;Signal Transduction;small molecule inhibitor;Supplementation;synergism;tau aggregation;Testing;Therapeutic;Thrombosis;Toxin;translational impact;United States;Vascular Endothelium;vascular injury;Vascular Permeabilities;Wisconsin;Work;young adult

PROJECT_TITLE: Exploring the role of Imidazole Propionate on Alzheimer’s Disease and Related Dementias

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Mental Health;Neurosciences;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Public Health Relevance Maternal obesity, which affects 20 million women in the United States, is one of the strongest risk factors for childhood obesity. Children born to mothers with pre-pregnancy obesity are up to four times more likely to develop obesity in the lifecourse, fueling a cycle of intergenerational transmission complicated by serious health consequences. The proposed study will contribute to our understanding of the role of the in utero environment in shaping neural and behavioral processes that predispose towards obesity development.

PI_NAMEs: MONTHE-DREZE, CARMEN TCHOKONTHE (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: 5 year old;Accounting;Address;adipocyte biology;Adipocytes;adipokines;adiponectin;Adult;Affect;Age;aged;Amygdaloid structure;Anisotropy;Anterior;Assessment tool;Attention;Behavior;Behavioral;biobank;Biological Markers;Birth;Body mass index;Brain;career development;Child;Chronic Disease;Clinical;cohort;Conceptions;critical period;Data;Data Set;design;Development;Development Plans;developmental plasticity;Diet;dietary;Dietary Assessment;Diffusion Magnetic Resonance Imaging;Dorsal;Eating Behavior;Environment;excessive weight gain;executive function;Experimental Models;Exposure to;fetal;Fetal Development;Food Intake Regulation;Foundations;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Growth;Health;high body mass index;High Fat Diet;Human;in utero;indexing;Infant;Inflammation;Inflammatory;Informal Social Control;innovation;insight;Instruction;Interdisciplinary Study;interest;intergenerational;Interleukin-6;Intervention;Knowledge;Knowledge acquisition;Laboratories;Leptin;Life;Life Cycle Stages;Link;Longitudinal cohort;Longitudinal Studies;maternal obesity;Measures;Mediating;Mediation;Mentorship;Metabolic;Methodology;Methods;Modeling;Mothers;Multimodal Imaging;Neonatal;neonatal brain;neural;neurobehavior;neurobehavioral;Neurobiology;Neurocognitive;neurodevelopment;neuroimaging;neuromechanism;Newborn Infant;nonhuman primate;Obesity;obesity development;obesity in children;obesity prevention;obesity risk;obesogenic;Parents;Phenotype;Pilot Projects;Positioning Attribute;postnatal;Pregnancy;prenatal;prenatal exposure;prepregnancy obesity;Prevalence;Prevention;Process;programs;prospective;Public Health;public health relevance;putamen;Questionnaires;Reporting;Research;Research Personnel;resistin;Rest;reward processing;Rewards;Risk Factors;Rodent;Role;secondary analysis;sex;Shapes;skills;Standardization;Structure;support network;Testing;Thalamic structure;TNF gene;Toddler;Training;transmission process;United States;Variant;Weight;Woman;Work

PROJECT_TITLE: Neurobiobehavioral Underpinnings of Intergenerational Obesity

STUDY_SECTION: DDK


ADMINISTERING_IC: AI

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Betacoronaviruses, including SARS-CoV-2, SARS-CoV and pre-emergent bat coronaviruses, pose a significant threat to human health and broad countermeasures to prevent and treat these viruses are urgently needed. The spike subunit 2 (S2) of betacoronaviruses is highly conserved, making it an attractive target for broadly acting therapeutics. This proposal will generate new knowledge about the function of S2-directed antibodies and inform novel approaches to vaccine development and antibody therapeutics for betacoronaviruses.

PI_NAMEs: MILLER, EMILY HAPPY (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;Adaptive Immune System;Animals;Antibodies;antibody engineering;Antibody Response;antibody test;Antibody Therapy;antibody-dependent cell cytotoxicity;antibody-dependent cellular phagocytosis;Antibody-mediated protection;Antigens;betacoronavirus;Binding;Biological Assay;Bispecific Antibodies;C-Peptide;career;Cells;Cessation of life;Chiroptera;climate change;combat;Complement-Dependent Cytotoxicity;Coronavirus;COVID-19 susceptibility;COVID-19 treatment;cross immunity;Data;design;Development;Effectiveness;Engineering;Epitopes;Foundations;Future;future pandemic;Glycoproteins;Goals;Habitats;Health;Human;human monoclonal antibodies;Immune response;Immunity;Immunization;Immunize;immunogenic;In Vitro;Infection;inhibitor;Innate Immune System;Knowledge;land use;Learning;Length;Link;Mediating;Membrane Fusion;Middle East Respiratory Syndrome Coronavirus;Monoclonal Antibodies;Monoclonal Antibody Therapy;Mus;Mutation;neutralizing antibody;novel;novel coronavirus;novel strategies;novel therapeutics;pandemic disease;pandemic preparedness;pathogen;pathogenic virus;Pathogenicity;Persons;Play;Population Growth;prevent;Property;Proteins;receptor binding;Risk;Role;SARS coronavirus;SARS-CoV-2 antibody;SARS-CoV-2 variant;Scientist;Serology;System;Testing;Therapeutic;Therapeutic antibodies;therapeutic target;tool;Training;Treatment Efficacy;Vaccination;vaccine development;Vaccine Therapy;vaccine-induced antibodies;Vaccines;Vesicular stomatitis Indiana virus;Viral;viral entry inhibitor;Virulent;Virus;Virus Diseases

PROJECT_TITLE: Engineering Immunity for Broad Protection Against Betacoronaviruses

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Patient Safety;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE: Tobacco use disorder is the most common substance use disorder in the US with many current smokers displaying dependence, which can lead to premature death and further health inequities. American Indian people have the highest tobacco use rates, and it is important to investigate the genetic, epigenetic, and environmental influences on nicotine metabolism and its relationship to smoking cessation efficacy. Merging innovations in pharmacogenomics and community-based participatory research in partnership with the Strong Heart Study, the largest ongoing epidemiological study to involve American Indian communities, to develop an Indigenous precision pharmacogenomics approach to smoking cessation is lacking in the field and holds promise to support and create equitable access to innovative smoking cessation efforts through personalized treatment and culturally appropriate interventions.

PI_NAMEs: CLAW, KATRINA G (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: Alaska Native;Alaska Native population;American Indian community;American Indian Population;American Indians;Area;Behavioral;Cardiovascular Diseases;Cessation of life;Cessation Research;Cohort Studies;Communities;community based participatory research;community engagement;community involvement;comorbidity;Complex;culturally appropriate intervention;Dependence;Disease;DNA Resequencing;epidemiology study;Epigenetic Process;epigenome-wide association studies;epigenomics;Equity;ethnic minority population;Ethnic Population;Future;Genetic;Genetic Risk;genome-wide;Genomics;health equity;health equity promotion;health inequalities;Health Priorities;Heart;improved;Indigenous;Individual;innovation;interest;Knowledge;Maps;marginalized population;Metabolism;Methods;Nicotine;novel strategies;Outcome;Outcome Study;personalized approach;personalized medicine;Pharmacogenomics;Phase;precision medicine;premature;racial diversity;racial minority population;racial population;reduced substance use;Research;Research Personnel;Research Priority;Research Proposals;Risk Factors;risk prediction;Running;Science;Smoker;Smoking;Smoking and Health Research;Smoking Behavior;smoking cessation;Smoking Cessation Intervention;smoking intervention;Substance Use Disorder;Tobacco;Tobacco use;Tobacco Use Cessation;Tobacco Use Disorder;trait;United States;Variant

PROJECT_TITLE: Precision pharmacogenomics and Indigenous research: A novel approach to tobacco cessation efficacy in American Indian communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKP-E (M1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Patient Safety

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Prescribing cascades are an insidious type of suboptimal medication prescribing that occurs when adverse events from one medication are misinterpreted as symptoms of a new medical condition and result in the addition of a new unnecessary medication, thereby predisposing patients to additional adverse events and major harms. This research will identify important prescribing cascades and rigorously examine their effects on health outcomes in older nursing home residents with Alzheimer's Disease and Related Dementias. Study findings will provide evidence that directly informs medication prescribing, deprescribing, and management to improve the safe use of medications among nursing home residents with Alzheimer's Disease and Related Dementias.

PI_NAMEs: HAYES, KALEEN NICOLE;ZULLO, ANDREW REIS (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adverse drug event;Adverse effects;Adverse event;adverse outcome;Affect;Alzheimer's disease related dementia;Calcium Channel Blockers;Cessation of life;Characteristics;Clinical assessments;clinically actionable;clinically relevant;clinically significant;cognitive function;Communication impairment;Data;data resource;Data Set;Databases;Diuretics;Dose;Drug Prescriptions;Drug usage;Edema;Electronic Health Record;epidemiology study;experience;Exposure to;fall injury;frailty;Frequencies;Future;Goals;Health;Health Insurance;Heart failure;high risk;Hospitalization;Hour;Impaired cognition;improved;Individual;innovation;insurance claims;Intervention;Joints;Knowledge;large datasets;Link;longitudinal database;Medical;Medicare;Medicare claim;Medication Management;Methodology;Methods;mortality;multidisciplinary;multiple chronic conditions;National Institute on Aging;novel;Nursing Homes;older adult;Outcome;Patients;Peripheral;Pharmaceutical Preparations;Pharmacoepidemiology;Physical Function;Polypharmacy;Provider;Records;Research;Risk;Risk Factors;risk minimization;Series;Subgroup;symptom management;Symptoms;Testing;Work

PROJECT_TITLE: Prescribing Cascades among Nursing Home Residents with ADRD

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Heart Disease;Pediatric;Physical Activity;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: NARRATIVE The proposed research is relevant to public health because the prevalence of physical inactivity in children with the FC is excessively high and consequently, they have reduced physical fitness and poor long-term outcomes. Pediatric cardiology teams should promote physical activity in children with the FC, but currently they lack the necessary tools to do so in the home setting. This project aims to develop and test the efficacy of a mobile health platform for pediatric cardiology teams to promote physical activity in children with the FC and is relevant to the NHLBI’s mission to develop and optimize novel therapeutic strategies to treat heart disease.

PI_NAMEs: GOLDMUNTZ, ELIZABETH  (contact);MITCHELL, JONATHAN ANDREW

PROGRAM_OFFICER_NAME: SCHWARTZ, BRYANNA NICOLE

PROJECT_TERMS: Accelerometer;Address;Aerobic;Aerobic Exercise;Age;aged;arm;Behavior;Behavior Therapy;behavioral economics;Cardiac Surgery procedures;Cardiology;Caregiver support;Caregivers;Caring;Characteristics;Child;Circulation;Clinical;Clinical assessments;clinical care;clinically relevant;congenital heart abnormality;cost;Densitometry;digital;digital health;digital intervention;Dual-Energy X-Ray Absorptiometry;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;efficacy evaluation;efficacy testing;Eligibility Determination;Equity;Exercise;exercise intervention;exercise program;Exercise stress test;Exposure to;falls;Family;family structure;Feedback;Foundations;future implementation;Goals;Health;health application;Health behavior;Heart Diseases;Home;Hospitals;Hybrids;implementation trial;improved;Incentives;Individual;innovation;instrument;Intervention;Interview;Knowledge;Measures;Medical;member;mHealth;Mission;mortality;muscle form;muscle strength;National Heart, Lung, and Blood Institute;Neighborhoods;novel therapeutic intervention;Operative Surgical Procedures;Outcome;Participant;Patients;Pediatric cardiology;Pediatric Hospitals;peer;Performance;Philadelphia;Physical activity;Physical Fitness;physical inactivity;point of care;post intervention;Predictive Factor;Prevalence;programs;Public Health;Public Health Informatics;Quality of life;Randomized;Randomized, Controlled Trials;Research;Research Methodology;resistance exercise;sex;Skeletal Muscle;Social Environment;sociodemographics;Surveys;Testing;therapy design;tool;Training;treatment arm;treatment as usual;Treatment Efficacy;usual care arm;Work;Wrist;Youth

PROJECT_TITLE: Home-Based, Digital Intervention to Increase Physical Activity in Patients with the Fontan Circulation

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT (MA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: PUBLIC HEALTH RELEVANCE: Alzheimer’s disease (AD) is a major public health crisis predicted to affect 13.8 million Americans and cost $750 billion per year by 2050. Better understanding pathological mechanisms underlying AD is critical to finding treatment and preventing this public heath crisis.

PI_NAMEs: HUANG, ZHEN  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: abeta accumulation;Abeta synthesis;Acceleration;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;American;Amyloid beta-Protein;Amyloidosis;Animal Disease Models;Animal Model;Antibodies;Astrocytes;Atrophic;Automobile Driving;Binding Proteins;Biology;Brain;brain cell;brain control;Brain region;cell type;Cells;Clinical;Compensation;cost;cytokine;Dementia;Deterioration;Development;Disease;DNA Sequence Alteration;drug discovery;Early Onset Alzheimer Disease;effective intervention;entorhinal cortex;experimental study;Family;Future;G-Protein-Coupled Receptors;Genes;Goals;Heterotrimeric GTP-Binding Proteins;Hippocampus;Human;Impaired cognition;Impairment;Inflammatory;insight;Late Onset Alzheimer Disease;Link;member;Memory impairment;Metabolism;Microglia;Microtubules;mild cognitive impairment;Modeling;Molecular;Molecular Chaperones;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Neocortex;Nerve Degeneration;Neurofibrillary Tangles;Neuroglia;neuroinflammation;Neurons;novel;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Pharmacologic Substance;Phenotype;Pilot Projects;piriform cortex;Play;prevent;Production;prospective;Public Health;public health relevance;Regulation;Research;risk variant;Role;Severities;Site;Stereotyping;Symptoms;Synapses;tau expression;tau Proteins;tau-1;tau-protein kinase;Tauopathies;Testing;Time;Uncertainty

PROJECT_TITLE: A Mouse Model for Braak I/II Alzheimer's Pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-M (03)]


ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Project Narrative Viral lower respiratory tract infections are a major cause of mortality in young children and severe disease can be associated with a suppressed immune response. Myeloid-derived suppressor cells (MDSC) are known to potently suppress T cells and contribute to impaired immune response. In a single-center, prospective, observational study we will test the hypotheses that expansion of MDSC will be associated with worse clinical outcomes and decreased numbers of CD4+ and CD8+ T cells in children with severe viral LRTI, and that pediatric MDSC-induced T cell suppression is preventable through PD-1 blockade.

PI_NAMEs: BLINE, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: 5 year old;adaptive immune response;Admission activity;Adult;Age;Allogenic;Anti-Inflammatory Agents;Apoptotic;Applications Grants;Blood specimen;Cancer Vaccines;career;Cause of Death;CD28 gene;CD3 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell age;Cell Count;Cell Physiology;Cell surface;Cells;Cessation of life;Characteristics;chemotherapy;Child;Childhood;Clinical;Clinical Data;Clinical Research;Clinical Trials;Coculture Techniques;Computerized Medical Record;COVID-19;Critical Care;Critical Illness;Critically ill children;cytokine;Data;design;Development;Disease;Enrollment;experience;Experimental Designs;experimental study;fighting;Flow Cytometry;Frequencies;Future;Goals;granulocyte;HLA-DR Antigens;Homeostasis;Hospitalization;Hour;Immune;Immune response;Immunobiology;Immunologic Monitoring;Immunologics;immunomodulatory therapies;Immunophenotyping;immunoregulation;Impairment;improved;improved outcome;In Vitro;in vitro Model;Induction of Apoptosis;Inflammatory;inhibitor;Investigation;K-Series Research Career Programs;Knowledge;Literature;Lower Respiratory Tract Infection;Lymphocyte;Lymphocyte Subset;magnetic beads;Measures;Mediating;Mentors;monocyte;mortality;mortality risk;Myeloid-derived suppressor cells;Nosocomial Infections;novel;Observational Study;Oncology;Outcome;pathogenic virus;Pathway interactions;patient oriented;Patient Selection;Patients;PD-1 blockade;PD-1 pathway;peripheral blood;Peripheral Blood Mononuclear Cell;Phenotype;Physicians;Play;Population;pressure;Production;Productivity;programmed cell death ligand 1;programmed cell death protein 1;programs;prospective;Regulatory T-Lymphocyte;Reporting;Research;respiratory;Risk;Role;Sampling;Scientist;Septic Shock;severe COVID-19;Severity of illness;single-cell RNA sequencing;Stains;Statistical Data Interpretation;Supportive care;T-Cell Proliferation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;therapeutic target;tool;Training;Treatment Protocols;Tumor Burden;vasoactive agent;Viral;Viral Respiratory Tract Infection;Virus;ward;Work

PROJECT_TITLE: Myeloid-derived suppressor cells modulate disease severity in children with viral lower respiratory tract infections

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (MA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Primary Health Care

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: Project Narrative Although many persons living with dementia prefer to remain at home as long as possible, they spend a great deal of time in institutional settings, such as acute care hospitals, skilled-nursing facilities, and long-term care nursing homes. The investigators will assess impact of physician, hospital, and skilled-nursing facility factors related to geriatric care on days spent at home in dementia care using a comprehensive data set. This research will inform future policies to improve care for persons living with dementia.

PI_NAMEs: GOTANDA, HIROSHI  (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Age;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Ambulatory Care;American Hospital Association;American Medical Association;care outcomes;Caring;Certification;Clinical;clinical outcome measures;Data;Data Set;Dementia;dementia care;Elderly;experience;Friends;Future;geographic difference;Geriatrics;Health care facility;health care service organization;Health system;Healthcare Market;Healthcare Systems;Home;Home Nursing Care;hospital care;Hospitalization;Hospitals;improved;Incentives;Institution;instrument;Intervention;Journals;Knowledge;Link;Literature;Long-Term Care Nursing;Medicare;member;Methods;mortality;Nurses;older adult;Older Population;Outcome;Outcome Measure;Patient-Focused Outcomes;Patients;person centered;Persons;Pharmacists;physical therapist;Physicians;Policies;Population;Primary Care Physician;programs;provider factors;Quality of Care;Quasi-experiment;readmission rates;Research;Research Personnel;Role;Skilled Nursing Facilities;Social Workers;Surveys;Time;Training

PROJECT_TITLE: Impact of physician, hospital, and skilled-nursing facility factors related to geriatric care on days spent at home among persons with AD/ADRD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PHR: Project Narrative NUT carcinoma is an incurable highly aggressive cancer driven by the BRD4-NUT oncoprotein that has a median survival of 6.5 months with no effective treatment options. We predict the proposed studies will identify novel mechanisms that synergize to drive NC growth while blocking differentiation that will facilitate precise and effective therapeutic targeting. The findings will greatly impact treatment of NC and likely other BRD4-dependent and pediatric fusion-driven cancers.

PI_NAMEs: EAGEN, KYLE PATRICK;FRENCH, CHRISTOPHER A (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Address;Adolescent and Young Adult;Affect;Animals;Binding;Biochemical;Biology;Bromodomains and extra-terminal domain inhibitor;Cancer Biology;Childhood;Chromatin;Chromatin Loop;clinical efficacy;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Combined Modality Therapy;Complex;Data;effective therapy;Epigenetic Process;epigenome;EZH2 gene;Fusion Oncogene Proteins;Gene Expression;Gene Expression Regulation;Genes;Genetic Screening;Genetic Transcription;Genetically Engineered Mouse;Goals;Growth;histone methyltransferase;histone modification;Human;improved;In Vitro;in vivo;inhibitor;Malignant Childhood Neoplasm;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;MLL gene;Modification;Mus;new therapeutic target;novel;Nut carcinoma;Nuts;Oncogene Activation;Oncogenic;Oncoproteins;Open Reading Frames;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;pre-clinical;Pre-Clinical Model;preclinical study;programs;Proliferating;promoter;protein complex;Proteomics;Regulation;Repression;Resistance;response;Role;scaffold;small molecule;Squamous Differentiation;Sum;synergism;Testing;therapeutic target;therapeutically effective;three dimensional structure;Toxic effect;transcriptomics;tumor growth;Tumor Promoters;Tumor Suppressor Genes;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Overcoming Limitations of BETInhibition in NUT Carcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (M2)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Immunotherapy;Lung;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE There is a critical need to develop effective treatments for acute respiratory distress syndrome (ARDS) which would limit inflammatory lung injury and improve patient outcomes. Novel cellular immune therapies represent one potential strategy to ameliorate the course of ARDS. In this research we will study the role of B cells in a mouse model of acute lung injury and their utilization as cellular immunotherapy to treat acute lung injury.

PI_NAMEs: HANIDZIAR, DUSAN  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Adopted;Adoptive Transfer;Alveolar;Animal Model;Anti-Inflammatory Agents;Award;B cell therapy;B-Cell Antigen Receptor;B-Lymphocyte Subsets;B-Lymphocytes;Blood;C57BL/6 Mouse;Cell Communication;Cell Count;Cell Death;Cells;Cellular immunotherapy;Clinical;COVID-19;Critical Illness;cytokine;Cytometry;Data;diabetic;Diffuse;effective therapy;Ensure;Exposure to;Funding;healing;Histology;Hour;Hyperoxia;Immune;immune cell infiltrate;Immune response;Immunoglobulins;immunoregulation;Immunotherapy;Impairment;improved;in vivo;Infiltration;Inflammation;Inflammatory;inhibitor;Injury;Interleukin-10;Investigation;Link;Lung;lung injury;lysophosphatidic acid;Mediating;Mediator;Memory;migration;Modeling;mouse model;Mus;Myocardial Infarction;neutrophil;Neutrophil Infiltration;novel;organ injury;Oxygen;Pathogenicity;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Plasma Cells;Pneumonia;Population;preservation;Process;Production;Proliferating;protective effect;PTPRC gene;pulmonary function;Pulmonary Inflammation;Receptor Signaling;Reporting;Research;Research Personnel;response;Role;Sepsis;Severities;Site;skin ulcer;Spleen;Supplementation;Testing;Therapeutic;Tissues;Traumatic Brain Injury

PROJECT_TITLE: Protective role of B cells in hyperoxic lung injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-N (M1)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Cancer;Liver Disease;Nanotechnology;Rare Diseases

ORG_CITY: NOTRE DAME

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project Narrative We integrate two technologies to provide rapid point-of-care assessment of Hepatitis C viral load from untreated blood samples at the point of care. One is an ANM technology to isolation and enrichment HCV and EVs in blood samples while the other is a new PCR-free optical microparticle assay that can quantify the virus load directly and rapidly. The integrated device is manual, turn-key and portable. If successful, it is expected to significantly lower the mortality of Hepatitis C virus related liver diseases and introduce a new virus detection platform.

PI_NAMEs: CHANG, HSUEH-CHIA  (contact)

PROGRAM_OFFICER_NAME: DYALL, JULIE

PROJECT_TERMS: Antibodies;antibody test;antigen test;Attention;Binding;Biological Assay;Biological Markers;Biological Sciences;Blood;Blood capillaries;Blood Cells;Blood specimen;Businesses;Cause of Death;Cellular Phone;Cessation of life;Clinical;Clinical Trials;Collection;Communicable Diseases;cost;Country;COVID-19 pandemic;design;detection limit;detection platform;Developed Countries;Developing Countries;Devices;Diagnosis;Diagnostic;Diagnostic tests;Excision;extracellular vesicles;Fingers;Funding;Goals;Hepatitis C;Hepatitis C virus;Human Resources;Image;Imaging Device;imaging system;Infection;instrumentation;Label;Laboratories;Lentivirus;Liver diseases;liver injury;Malignant neoplasm of liver;Manuals;Membrane;Membrane Glycoproteins;Membrane Proteins;Microspheres;mortality;multiplex detection;nanopore;new technology;novel;operation;Optics;particle;Patients;Persons;point of care;point of care testing;point-of-care diagnostics;portability;Preparation;Primary carcinoma of the liver cells;Process;protein biomarkers;Proteins;prototype;Puncture procedure;Resistance;Resources;Reverse Transcription;RNA;Saliva;saliva sample;Sampling;scale up;screening;Severities;Signal Transduction;Step Tests;Surface;Technology;Testing;Travel;Tube;Ultrafiltration;Viral;viral detection;Viral load measurement;Viral Load result;viral RNA;Virion;Virus;virus testing

PROJECT_TITLE: A Novel Janus Bead Blood Assay for Point-of-Care Assessment of HCV Viral Load and Associated Liver Damage

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: DERMATOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The purpose of this proposed renewal of a K24 Midcareer Investigator Award is to mentor the next generation of patient-oriented researchers focused on improving the care of vulnerable populations with skin disease. The mentorship goals of this proposal are aligned with the research aims. We will use novel machine learning, quantitative and qualitative methods in order to highlight opportunities for improved care for two vulnerable groups of patients: a) the elderly and b) racial and ethnic minorities.

PI_NAMEs: LINOS, ELENI  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Academic Medical Centers;Address;Affect;Age;Area;Artificial Intelligence;Award;Behavioral Sciences;Bioethics;Black race;career;Caring;Clinic Visits;Clinical;Clinical assessments;Collaborations;Data;Data Analyses;Data Collection;Dermatologic;Dermatology;digital health;digital monitoring;digital tool;Disease;Disease Progression;Elderly;Electronic Health Record;Eligibility Determination;Ensure;ethnic minority;ethnic minority population;Ethnic Origin;experience;Faculty;Funding;Future;Geographic Locations;Geriatrics;Goals;hands on research;Health;health care disparity;Health Disparities Research;Hidradenitis;Hidradenitis Suppurativa;Hispanic;Home;Image;image archival system;improved;Interview;K-Series Research Career Programs;Knowledge;large language model;Machine Learning;Measures;Medical Students;Medicine;member;Mental Health;Mentors;Mentorship;Methodology;Mid-Career Clinical Scientist Award (K24);Midcareer Investigator Award in Patient-Oriented Research;minority patient;Mission;Monitor;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural History;Natural Language Processing;next generation;novel;older adult;older patient;Pain;Participant;Patient Care;patient oriented;patient oriented research;patient population;Patients;Persons;Physicians;Population;Population Heterogeneity;Positioning Attribute;Primary Care;professor;programs;Provider;Qualitative Methods;Qualitative Research;Quality of life;Race;racial minority;racial minority population;Reduce health disparities;Research;Research Personnel;Research Training;Role;Sampling;Scientist;senior faculty;serial imaging;skills;Skin;Skin Care;skin color;skin disorder;Sleep;social media;Socioeconomic Status;Structure;Symptoms;Techniques;Technology;Time;Training;Training Support;United States National Institutes of Health;Universities;virtual;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Patient Oriented Research in Vulnerable Populations with Skin Disease

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Hematology;Infectious Diseases;Sepsis

PHR: Project Narrative Atrial fibrillation is a common arrhythmia with downstream consequences that include stroke, heart failure, and death. Despite its growing burden, our understanding of the mechanistic basis of AF is incomplete and therapeutic interventions are limited in efficacy, associated with adverse effects, and have not seen any significant advances in years. This proposal aims to exploit a common signaling pathway that may underlie both genetic and acquired forms of atrial fibrillation, with an effort towards identifying novel therapeutic targets.

PI_NAMEs: BAPAT, ANEESH  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Address;Adverse effects;Advisory Committees;Affect;Arrhythmia;ATAC-seq;Atrial Fibrillation;Automobile Driving;Award;Biochemical;Biological;Biological Assay;Calcium;calmodulin-dependent protein kinase II;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;cardiogenesis;Cardiology;cardiovascular effects;Cardiovascular system;cecal ligation puncture;cell type;Cells;Cessation of life;Clinical;Critical Thinking;Data;Data Analyses;Dedications;Development;economic cost;efficacy evaluation;efficacy study;Electrophysiology (science);Enhancers;experience;Faculty;fetal;Fibroblasts;Fibrosis;Functional disorder;Future;General Hospitals;Genes;Genetic;Genetic study;Genetic Transcription;genetic variant;genome wide association study;genomic data;Germ Lines;Glucocorticoids;Goals;Heart;Heart Atrium;Heart failure;Human;Hypertension;Immune;Inflammation;interest;Link;Massachusetts;Mediating;medical schools;member;Mentors;Mentorship;mid-career faculty;Mitogen-Activated Protein Kinases;Modeling;Morbidity - disease rate;mortality;mouse model;multiple omics;Mus;new therapeutic target;novel;Nuclear RNA;Obesity;Pathogenesis;Pathologic;Pathology;Pathway interactions;Phenotype;Phosphotransferases;Physicians;Physiology;Population;Predisposition;Prevalence;Public Health;Publications;receptor;Reproducibility;Research;Research Personnel;Risk;Risk Factors;risk variant;Role;Scientist;Sepsis;Serum;Signal Pathway;Signal Transduction;skills;Sodium;stem;Stress;Stroke;Technical Expertise;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;Time;Tissues;Training;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;Up-Regulation;Variant;Ventricular Arrhythmia;WNT Signaling Pathway;Work;ZFHX3 gene

PROJECT_TITLE: WNT Signaling in the Pathogenesis of Atrial Fibrillation

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (MA)]


NIH_SPENDING_CATS: Aging;Genetics;Lung;Pulmonary Fibrosis;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Idiopathic pulmonary fibrosis (IPF) is a relentless interstitial pneumonia that claims the lives of more than 40,000 Americans every year and primarily presents in individuals over the age of 55. The goal of this project is to understand the effects of aging and disrupted metabolism in epithelial progenitor cells within the alveolar space of the fibrotic lung. This study has the potential of identifying new therapeutic options for a terrible disease that, currently, has only two FDA approved medications.

PI_NAMEs: RODRIGUEZ, LUIS R (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute;Address;Age;age effect;age related;age related changes;aged;Aging;aging mechanism;aging process;aging related disease;Alveolar;alveolar epithelium;alveolar homeostasis;alveolar type II cell;American;Architecture;Autophagocytosis;Biogenesis;Biology;career;Cells;Cellular Metabolic Process;Chromatin;Chromatin Structure;Chronic;COVID-19 pandemic;cytokine;Data;Defect;design;Diagnosis;Disease;Disease Progression;Disease susceptibility;Distal;Enzymes;Epigenetic Process;Epithelial Cells;epithelial stem cell;Epithelium;Event;extracellular;FDA approved;Fibroblasts;fibrogenesis;Fibrosis;fibrotic lung;Foundations;Functional disorder;Gene Delivery;gene therapy;Genes;Genetic;genetic approach;Goals;Homeostasis;Human;human data;human disease;human induced pluripotent stem cells;idiopathic pulmonary fibrosis;Impairment;In Vitro;in vivo;Individual;induced pluripotent stem cell;Inflammatory;Injury;interest;Interstitial Pneumonia;Intervention;knockout gene;Knowledge;Life Expectancy;Ligands;Light;Link;Lung;Lung Diseases;Measures;Mentors;Mesenchyme;Metabolic;Metabolic dysfunction;Metabolic stress;Metabolism;Missense Mutation;Mitochondria;mitochondrial metabolism;Modeling;Molecular;mortality;mouse model;Mus;mutant;Myofibroblast;new therapeutic target;novel;novel therapeutics;old mice;Organoids;Pathogenesis;Patients;Pharmaceutical Preparations;Phenotype;Population;post-doctoral training;pre-clinical;Predisposition;Prevalence;pro-aging;proteostasis;Pulmonary Fibrosis;Pulmonary Surfactant-Associated Protein C;Quality Control;Reactive Oxygen Species;regenerative;Resolution;Role;Scientist;senescence;Severities;Severity of illness;Signal Transduction;single cell sequencing;Source;stem cell biology;stem cell function;stem cell model;stem cells;Telomere Shortening;Testing;Time;Training;Transitional Cell;Type I Epithelial Receptor Cell;Type II Epithelial Receptor Cell;Viral;Work;wound healing

PROJECT_TITLE: Aging and Metabolic Dysfunction Drive Disrupted Alveolar Epithelial Progenitor Function in Pulmonary Fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-N (M2)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Data Science;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Leveraging the recent breakthrough in protein structure prediction and progress in the analysis of protein sequences and structures using Artificial Intelligence, I will study the rapidly evolving and pathogenicity-associated proteins encoded by the pan-genomes of Vibrio species that cause vibriosis in humans. This project will establish a framework to combine computational tool development and large-scale data analysis with experimental validation to decipher protein functions, contributing to our understanding of the pathogenicity of bacteria and human diseases.

PI_NAMEs: ZHANG, JING  (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Active Sites;Address;arms race;Artificial Intelligence;artificial intelligence method;Bacteria;Bioinformatics;Biological;Biological Assay;candidate identification;Categories;Cells;Classification;Clinical;Communities;comparative genomics;Complement;computational pipelines;Computer Analysis;computer studies;computerized tools;Computing Methodologies;Consumption;Core Protein;Coupled;Cytoplasmic Protein;cytotoxicity;Data;Data Analyses;Data Set;Databases;Dedications;deep learning;Development;Evolution;experimental study;Family;forging;Foundations;functional gain;Future;Genes;Genome;Health;Homologous Gene;Human;human disease;Immune system;improved;insight;Invaded;Investigation;Laboratories;large datasets;large scale data;learning network;Literature;Location;Mass Spectrum Analysis;Metadata;Methods;Mining;Modeling;Molecular Evolution;multidisciplinary;Mutagenesis;Nature;novel;Nucleic Acid Sequence Homology;pan-genome;pathogen;pathogenic bacteria;Pathogenicity;Patients;Phase;Phenotype;Protein Family;protein function;protein protein interaction;Protein Secretion;Protein Sequence Analysis;protein structure;protein structure prediction;Proteins;Proteome;public database;Research;Role;Science;Sequence Alignment;Solid;Structure;success;Techniques;Testing;three dimensional structure;three-dimensional modeling;Time;tool;tool development;Training;Validation;Vibrio;Vibrio alginolyticus;Vibrio Infections;Vibrio parahaemolyticus;Vibrio vulnificus;Virulence Factors;web server;yeast two hybrid system

PROJECT_TITLE: Functions of Rapidly-Evolving Proteins and Their Roles in Pathogenicity

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Delays in lung cancer diagnosis result in death or other serious harms for tens of thousands of Americans each year. This comprehensive study of the lung cancer diagnostic process aims to describe patient, provider, and system-related factors contributing to these delays. The outcomes of this research will deepen understanding of the diagnostic process for lung cancer, lay the groundwork for developing tailored interventions to improve diagnostic safety and equity, and ultimately yield better patient outcomes in Maryland and nationwide.

PI_NAMEs: HASSOON, AHMED  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Achieving Excellence in Lung Cancer Diagnosis through System-Level Analysis of Diagnostic Performance

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative Cardiovascular disease is the leading cause of death and disability in industrialized nations and its prevalence is rising rapidly in developing countries. Mutations in nuclear envelope proteins cause devastating genetic diseases characterized by the presence of high levels of DNA damage and skeletal muscle and cardiac phenotypes. This proposal aims to elucidate the underlying molecular and cellular mechanisms of these diseases in order to strategically design specific therapies.

PI_NAMEs: CARAVIA, XURDE MENENDEZ (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Adaptor Signaling Protein;Affect;American;Area;Automobile Driving;Binding Proteins;Bioinformatics;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;Cause of Death;Cell Differentiation process;Cell Nucleus;Cessation of life;Chromatin;Chronic;Code;Cytoplasm;Data;Dependovirus;design;Developed Countries;Developing Countries;Development;Dilated Cardiomyopathy;disability;Disease;DNA;DNA Damage;DNA Sequence Alteration;DNA-Binding Proteins;env Gene Products;epidemiologic data;Exhibits;experimental study;Extravasation;Family;Gene Expression;gene therapy;Genes;Genetic Diseases;Genetic Transcription;Genome;Genotype;Goals;Grant;Heart;Heart Diseases;Heart failure;heart function;Homeostasis;Human;Human Genetics;humanized mouse;improved;In Vitro;in vivo;induced pluripotent stem cell;Inflammatory;inherited cardiomyopathy;insight;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Lamin Type A;Link;loss of function;Measures;Mechanical Stress;Membrane Proteins;Methods;Missense Mutation;Modeling;Molecular;mortality;Mus;mutant;Mutant Strains Mice;Mutation;Myocardium;novel therapeutic intervention;Nuclear Envelope;Nuclear Inner Membrane;overexpression;Pathogenesis;Pathologic;Pathway interactions;Performance;Phenotype;Play;Predisposition;premature;Prevalence;Preventive;Process;Publishing;Regulation;Reporting;Research;response;Role;Rupture;single nucleus RNA-sequencing;Skeletal Muscle;stem cell model;Stimulator of Interferon Genes;Testing;Therapeutic;Training;transcriptomics;transmission process

PROJECT_TITLE: Understanding the roles of nuclear envelope proteins and DNA damage in cardiomyopathy

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (MA)]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project Narrative RNA posttranscriptional modifications emerged as a key regulatory component of cardiac gene expression and function, influencing various cardiovascular diseases. RBPMS is a novel regulator of RNA posttranscriptional modification in the heart, modulating heart function and disease progression. Through the study of RBPMS, the proposal aims to gain insights into the fundamental mechanisms whereby RNA binding proteins regulate cardiac function and develop new potential therapeutics for cardiovascular disease.

PI_NAMEs: GAN, PEIHENG  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Adult;Advisory Committees;Alternative Splicing;Animal Model;Biological Assay;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiovascular Diseases;Cardiovascular system;career development;Cause of Death;Complement;Cytoskeletal Proteins;Data;Disease Progression;Doxorubicin;Epigenetic Process;Event;experimental study;Faculty;forging;Gene Expression;gene function;Genes;Genetic Transcription;Heart;Heart Contractilities;Heart Diseases;Heart failure;heart function;Homeostasis;Human;human induced pluripotent stem cells;Impairment;In Vitro;in vitro Assay;in vitro Model;induced pluripotent stem cell derived cardiomyocytes;insight;Institution;knock-down;Knowledge;Learning;Measures;Mediating;Medical center;Mentors;Modeling;Molecular;mortality;mouse model;Mus;novel;Outcome;overexpression;Patients;Pattern;Phase;Physiology;Play;Positioning Attribute;Post-Transcriptional Regulation;Post-Transcriptional RNA Processing;posttranscriptional;prevent;Process;programs;Proliferating;protective effect;protein expression;Protein Isoforms;Public Health;Reporting;Research;Resources;RNA Splicing;RNA-Binding Proteins;Role;Spliced Genes;Study Skills;support network;tenure track;Testing;Therapeutic;Therapeutic Studies;tool;Training;Training and Education;training opportunity;transcription factor;Transcriptional Regulation;Viral

PROJECT_TITLE: RBPMS, a novel RNA splicing regulator of cardiac function and disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Telehealth

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Medicare coverage expansions for telehealth and increasing demand for telehealth services during the COVID-19 pandemic have led to a surge in telehealth use in nursing homes (NHs), which may impact the delivery of care for long- stay residents with Alzheimer's disease and related dementias (ADRD). This project will examine how telehealth is provided in NHs and its impact on the utilization, quality, and cost of care for long-stay NH residents with ADRD that are Medicare Fee-for-Service beneficiaries or are enrolled in Medicare Advantage. The results of this study will provide critical evidence to clinicians, payers, and policymakers on the uptake and impacts of telehealth use in these facilities and how telehealth is used in long-stay residents with ADRD.

PI_NAMEs: JUNG, HYE-YOUNG  (contact);YU, JIANI

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Administrator;Adoption;Affect;Alzheimer's disease related dementia;Ambulatory Care;beneficiary;Budgets;care costs;care delivery;Caregivers;Caring;Characteristics;Chronic;Cognitive;Communication;Consolidated Framework for Implementation Research;COVID-19;COVID-19 pandemic;Data;Decision Making;Disadvantaged;Disease;Emergency department visit;Enrollment;experience;Family;Family member;Fee-for-Service Plans;flexibility;gaps in access;Goals;Health Benefit;health care service;Health Services;Health Services Accessibility;Home Nursing Care;Hospitalization;Hour;human very old age (85+);improved;Individual;innovation;insight;Interview;Judgment;Leadership;Measures;Medical;medical specialties;Medicare;Memory impairment;Methods;Modality;Natural experiment;Nurse Administrator;nursing care quality;nursing home length of stay;Nursing Homes;older adult;Pain management;pandemic disease;Patient Care;patient oriented;Pattern;payment;Persons;Pharmaceutical Preparations;Physician Executives;Policies;Policy Maker;Population;Process;programs;Provider;public health emergency;Qualitative Methods;Quality of Care;Research;Resources;screening;Self Care;Services;Site;Structure;Supervision;Technology;telehealth;United States;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;uptake;Visit;Visiting Nurse;waiver

PROJECT_TITLE: Telehealth Use in Nursing Homes and the Quality of Care for Long-Stay Residents with Alzheimer's Disease and Related Dementias


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: DETROIT

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed research aims to understand how redirected CaMKIIa improves neuronal dysfunctions and memory deficits in Alzheimer's disease models. Thus, this proposal is relevant to the part of the NIH's mission that pertains to understanding the mechanisms of Alzheimer's disease and related dementia and developing approaches for therapeutic interventions.

PI_NAMEs: PARK, JOONGKYU  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Acceleration;adenovirus mediated delivery;age related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's Disease Pathway;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Amyloid;Animal Model;Antibodies;Architecture;Autopsy;Behavioral;Biology;Brain;Brain Diseases;Ca(2+)-Calmodulin Dependent Protein Kinase;calmodulin-dependent protein kinase II;Cells;cellular pathology;cognitive function;Complex;Cytoplasm;Dendritic Spines;Dependovirus;Development;Disease;Elements;Enzymes;fear memory;Foundations;Functional disorder;Future;Genetic;Hippocampus;Hyperactivity;hyperphosphorylated tau;Impairment;improved;In Vitro;in vivo;in vivo Model;insight;Intervention;Intrabody;Knowledge;Learning;Link;Mediating;Memory;Memory impairment;Mission;Molecular;Molecular Target;mouse model;Mus;N-Methyl-D-Aspartate Receptors;Neurofibrillary Tangles;Neuronal Dysfunction;Neurons;novel;novel therapeutics;paired helical filament;Pathogenesis;Pathologic;Pathology;Pathway interactions;Phosphorylation;Phosphotransferases;postsynaptic;Process;Proteins;Publications;Reporting;Research;Research Personnel;restoration;Role;Senile Plaques;Signal Transduction;Site;Solid;Symptoms;Synapses;synaptic function;Synaptic plasticity;tau mutation;tau Proteins;tau-1;Techniques;Tg2576;Therapeutic Intervention;United States National Institutes of Health;Work

PROJECT_TITLE: Redirected CaMKII for restoring deficits in Alzheimer's disease models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE “Advancing, Expanding, and Streamlining University of New Mexico Health Science Center Animal Resource Facility Rodent Housing Capabilities” requests funds to support purchase of ten ventilated mouse racks with cages/accessories and two Class II Type A2 animal handling biosafety cabinets as flexible clean working stations. The University of New Mexico (UNM) Health Sciences Center (HSC) Animal Resource Facility (ARF) supports approximately 77 biomedical and behavioral research investigator laboratories (44 PI laboratories affected by this project). This project, when completed, will allow us to increase needed cage capacity, improve room and cage air quality, and improve research procedural space as a means to sustain ongoing strategic goals: expand a productive partnership between the NIH and UNM HSC; develop new synergies among research programs to enhance Signature Programs (Brain and Behavioral Illnesses, Cancer, Cardiovascular and Metabolic Disease, Child Health Research, Environmental Health Sciences, and Infectious Diseases and Immunity); and modernize the animal core in compliance with required standards and maintenance of AAALAC accreditation.

PI_NAMEs: KONECNY, TARA  (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: Accreditation;Affect;Air;animal care;animal resource;Animals;Area;Behavioral;Behavioral Research;Biomedical Research;Brain;Breeding;Cardiovascular Diseases;Child Health;Communicable Diseases;Environmental Health;Equipment;exhaust;Faculty;Female;flexibility;Floor;Funding;germ free condition;Goals;Health Sciences;Housing;Immunity;improved;Individual;innovation;Laboratories;Maintenance;Malignant Neoplasms;Mechanics;Metabolic Diseases;Modernization;Mus;New Mexico;Productivity;programs;R24;Recommendation;Research;Research Personnel;Rodent;Side;square foot;synergism;United States National Institutes of Health;Universities;ventilation

PROJECT_TITLE: Advancing, Expanding, and Streamlining University of New Mexico Health Sciences Center Animal Resource Facility Rodent Housing Capabilities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-U (91)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cannabinoid Research;Data Science;Drug Abuse (NIDA only);Genetics;Human Genome;Mental Health;Neurosciences;Substance Misuse;Tobacco

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: PROJECT NARRATIVE Substance use disorders (SUDs) are complex and heritable mental disorders and a serious public health challenge, but the neurogenetic mechanism of addiction remains largely unknown. In this project, we focus on the human brain functional connectome and propose a novel transcriptome-connectome approach by developing novel transcriptome-wide association studies (TWAS) and meta-analysis methods to identify pleiotropic genes associated with both functional connectivity (FC) change and addiction to understand the neurogenetic mechanism of nicotine and cannabis addiction.

PI_NAMEs: MA, TIANZHOU  (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: addiction;Addictive Behavior;Alcohols;Area;Bayesian Modeling;Behavioral;Big Data;Biological;Board Certification;Brain;Brain imaging;Brain region;Cannabis;career;Classification;Clinical;Complex;connectome;Data;Data Analyses;Data Sources;Databases;Development;Disease;Environmental Risk Factor;experience;Functional Magnetic Resonance Imaging;Future;gene function;Genes;Genetic;Genetic study;genome wide association study;genome-wide;genomic locus;Goals;Grant;gray matter;Heritability;high dimensionality;Human;Image;imaging genetics;Imaging Techniques;improved;Knowledge;knowledge curation;Link;Magnetic Resonance Imaging;Marijuana Dependence;marijuana use;Mediation;Mental disorders;Mentored Research Scientist Development Award;Mentors;Mentorship;Meta-Analysis;method development;Methods;Modification;multiple omics;Neurobiology;neurogenetics;neuroimaging;Nicotine Dependence;Noise;novel;Pathway interactions;Pattern;Phenotype;Psychiatrist;Public Health;Quantitative Trait Loci;Reporting;Research;Research Personnel;Rest;Scientist;skills;software development;spatiotemporal;statistics;Structure;substance use;Substance Use Disorder;success;Time;Tissues;Tobacco;tool development;Training;trait;transcriptome;white matter;Work;Writing

PROJECT_TITLE: A novel transcriptome-connectome approach to study the neurogenetic mechanism of nicotine and cannabis addiction

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Epilepsy;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Many people with dementia suffer from epilepsy which is often not recognized in this patient population. The proposed research will contribute to fundamental knowledge by identifying clinical and genetic risk factors for epilepsy in people with dementia which could lead to early identification and treatment of epilepsy. This knowledge is relevant to public health because early identification and treatment of epilepsy could improve patient care and outcomes in people with dementia.

PI_NAMEs: ZAWAR, IFRAH  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;Age;Age of Onset;Algorithms;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Anticonvulsants;Apolipoprotein E;Biological Markers;Biometry;Blood Tests;Brain;Brain Neoplasms;career;career development;Characteristics;Clinical;clinical biomarkers;clinical practice;Clinical Research;clinical risk;Clinical Trials Design;Cognition;Cognitive;Cognitive deficits;comorbidity;Consent;Data;Data Science;Databases;Death Rate;Dementia;Detection;Diagnosis;Diagnostic;Disease;Doctor of Philosophy;Early Diagnosis;Early identification;Early treatment;Education;Educational workshop;Electroencephalography;Environment;Epilepsy;epileptiform;Feasibility Studies;feasibility testing;Foundations;Funding;genetic risk factor;genomic biomarker;Gerontology;Goals;Guidelines;Health Sciences;High Prevalence;high risk;high risk population;Home;Hour;Impaired cognition;improved;innovation;International;Knowledge;Logistic Regressions;Master of Science;Medical;Mental Depression;Mentors;Mentorship;Methods;Monitor;mortality;multidisciplinary;Mutation;National Center for Advancing Translational Sciences;Neurology;Neuropsychology;older adult;Outcome;Parkinson Disease;Participant;Patient Care;patient population;Patient-Focused Outcomes;Patients;Persons;Predictive Analytics;professor;programs;prospective;Prospective Studies;Public Health;Public Health Schools;Qualifying;Recording of previous events;recruit;Reporting;Reproducibility;Research;Research Design;Research Personnel;Resources;Risk;Risk Factors;risk stratification;Role;Scholars Program;Schools;Scientist;screening;Seizures;Severities;sex;Statistical Models;Stroke;Subclinical Seizures;Testing;tool;Training;Transient Ischemic Attack;Traumatic Brain Injury;United States National Institutes of Health;Universities;Vascular Dementia;Virginia

PROJECT_TITLE: Epilepsy in Alzheimer's disease and related dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-G (M4)]


NIH_SPENDING_CATS: Aging;Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE Cardiovascular disease is the leading cause of death and disability in the world, and with an aging population only expected to increase. Genetics play a significant role in the causes and outcomes of a heart attack, yet we know little about the etiology, pathways and modifiers of disease progression, nor do ideal biomarkers exist. Therefore, we are examining genetic effects of a mild heart attack on the left ventricle of the heart in mice and humans, and identifying markers in human and mouse plasma that can diagnose and treat the effects of the heart attack. Subsequently, we will verify these results in a much larger population of patients undergoing heart surgery.

PI_NAMEs: MUEHLSCHLEGEL, JOCHEN DANIEL (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Acute;Affect;aging population;Aneurysm;angiogenesis;Animal Model;Award;biobank;Biological;Biological Markers;Biological Process;Biology;biomarker identification;Cardiac;Cardiac Myocytes;Cardiac Surgery procedures;cardioprotection;Cardiopulmonary Bypass;Cardiovascular Diseases;Cause of Death;Cell Communication;Cell Death;cell type;Cells;Clinical;cohort;Complex;Development;Diagnosis;differential expression;disability;Disease;Disease Progression;Etiology;exosome;experience;Exposure to;extracellular;extracellular vesicles;Fibrosis;Future;Gene Expression;gene therapy;Genetic;Genetic study;Genetic Transcription;Genetic Variation;Genomics;Genotype;Heart;Heart failure;Heart Hypertrophy;Heart Ventricle;Heritability;Human;Human Genome;human model;human tissue;Hypoxia;immune activation;improved;Individual Differences;Infarction;Inflammation;Ischemia;ischemic injury;Left;Left ventricular structure;Link;Lipids;Mediating;Messenger RNA;MicroRNAs;Molecular;mortality;mouse model;mRNA Expression;Mus;Muscle Cells;Myocardial;Myocardial Infarction;myocardial injury;Myocardial Ischemia;Myocardial Reperfusion Injury;Myocardial tissue;Myocardium;National Heart, Lung, and Blood Institute;Outcome;Pathway interactions;patient population;Patient-Focused Outcomes;Patients;Perioperative;Peripheral;Phenotype;Plasma;Play;Population;Positioning Attribute;Postoperative Period;Process;programs;Property;Proteins;Quantitative Trait Loci;Regulation;Reperfusion Injury;Reperfusion Therapy;Reporter;Resources;response;RNA;Role;Sampling;Shapes;Small RNA;stressor;Testing;Therapeutic;Time;Tissue Sample;Tissues;trait;Transcriptional Regulation;transcriptome;transcriptome sequencing;Transgenic Organisms;Untranslated RNA;Variant;Ventricular;Ventricular Dysfunction;Ventricular Remodeling;whole genome

PROJECT_TITLE: Cardiac Exosomes in myocardial Ischemic injury

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Injury - Accidents and Adverse Effects;Prescription Drug Misuse;Prevention;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: HERSHEY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE Despite increasing concerns that stimulant therapy could contribute to stimulant use disorder and overdose in some adults, risk factors for such harms have not been well understood. This project, using existing large datasets, will apply machine learning to assess personal, clinical, and geo-socioeconomic characteristics of stimulant-treated adults to identify risk factors for stimulant use disorder and overdose, and design a clinical decision support tool for clinicians and patients who consider stimulant therapy, with the ultimate goal of reducing the risk of stimulant-related harm.

PI_NAMEs: TUAN, WEN-JAN  (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Accounting;acquired factor;addiction;Address;Adult;Affect;Area;Attention deficit hyperactivity disorder;Benefits and Risks;Big Data;career;Caring;Censuses;Characteristics;Clinical;clinical care;Clinical Data;clinical decision support;Clinical Decision Support Systems;clinical decision-making;clinical development;Clinical Informatics;clinical risk;Clinical Trials;clinically relevant;cost;Criminal Justice;Data;Data Pooling;Data Set;Databases;Death Rate;Decision Support Systems;deep learning model;design;Development;Diagnosis;digital;Disease;disorder risk;drug misuse;Drug Prescriptions;Economics;efficacy evaluation;Electronic Health Record;equity, diversity, and inclusion;experience;Foundations;Future;Goals;Health;Health behavior;Health Services Research;Health system;Healthcare;Human Subject Research;implementation science;implementation tool;improved;Individual;innovation;insight;interest;Intervention;Intervention Trial;K-Series Research Career Programs;Knowledge;large datasets;Leadership;Link;Loneliness;longitudinal analysis;Machine Learning;machine learning method;Mental Depression;Mental disorders;Mentored Research Scientist Development Award;Mentorship;Methods;Mission;Modeling;National Institute of Drug Abuse;Neighborhoods;Obesity;Outcome;Outcomes Research;Overdose;overdose death;overdose risk;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Play;point of care;Practice Guidelines;predictive modeling;Preparation;prescription stimulants;prevent;Prevention;Productivity;profiles in patients;prototype;Public Health;Reporting;Research;Risk;Risk Assessment;Risk Factors;risk minimization;risk prediction;Risk Reduction;Risk-Benefit Assessment;Role;Rural;Safety;Science;Scientist;Screening procedure;skills;social;social health determinants;socioeconomics;Stimulant;stimulant misuse;stimulant use;stimulant use disorder;Substance Addiction;substance use;Substance Use Disorder;support tools;System;Techniques;Testing;Time;tool;Training;trend;underserved community;usability

PROJECT_TITLE: Using machine learning to analyze integrated clinical and geo-social data to inform the design of a decision support system to reduce the risk of stimulant therapy

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Contraception/Reproduction;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ALBANY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ALBANY MEDICAL COLLEGE

PHR: PROJECT NARRATIVE Low androgen levels (andropause) in men increases risk of Alzheimer’s disease and related dementia. Models of andropause have been stalled for over a century and are limited to gonadectomy, which does not accurately mimic reduced androgen levels observed in andropause in men. The lack of models of andropause that more closely mimic the human hormonal profile is severely limiting the fields of aging and dementia; thus, the objective of this proposal is to develop two new mouse models of andropause.

PI_NAMEs: ZULOAGA, KRISTEN LEANNE (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: 3xTg-AD mouse;4-vinylcyclohexene diepoxide;Age;age acceleration;Age Months;age related decline;aged;Aging;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;Androgens;Andropause;Animals;Anxiety;behavioral phenotyping;capsule;Chronology;Data;Dementia;Development;Dose;early onset;Endocrine;Environment;Exhibits;Female;Goals;Gonadal Steroid Hormones;Hormonal;Hormones;Human;Impaired cognition;improved;Individual;male;Measures;Memory impairment;men;Menopause;Modeling;mouse model;Mus;neuropathology;normal aging;Orchiectomy;Organ Weight;Phenotype;preservation;Proxy;Rattus;Reporting;reproductive;reproductive organ;Research;Risk;Seminal;Seminal Vesicles;Serum;Testing;Testis;Testosterone;therapeutic evaluation;Time;Toxin;translational potential;Variant;Weight;Woman

PROJECT_TITLE: Developing new mouse models of andropause for ADRD research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-H (02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Complementary and Integrative Health;Dementia;Genetics;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Alzheimer’s disease (AD), the most common neurodegenerative disease, affects 1 in 8 people older than 65 in the US and arises through unknown genetic and environmental mechanisms hindering the development of effective therapeutic strategies. We recently discovered that APOE4, the strongest genetic risk factor for AD, alters cholesterol homeostasis in the human brain, which likely adversely interacts with high-fat/ketogenic diets to accelerate AD pathogenesis. Combing innovative in vitro models of the human brain with in vivo mouse studies we will gain an in-depth mechanistic understanding of how APOE genotype interacts with diet to modulate outcomes in AD that will identify potentially non-invasive, genetically targeted therapeutic and diagnostic strategies for AD and related dementias.

PI_NAMEs: BLANCHARD, JOEL WILLIAM (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Acceleration;Acetyl Coenzyme A;Affect;Age;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Axon;beta-Hydroxybutyrate;Biochemical;Biological;Biological Assay;Biological Availability;Biological Markers;Blood;Blood - brain barrier anatomy;Brain;Brain Diseases;brain tissue;Carbohydrates;cell type;Cells;Cerebrovascular system;Chemicals;Cholesterol;cholesterol biosynthesis;Cholesterol Homeostasis;cholesterol trafficking;Clinical Research;Clinical stratification;Clinical Trials;Cognition;Cognitive;cognitive ability;Complement;Complex;Coupled;Data;Dementia;Deposition;Development;Diagnostic;diagnostic biomarker;diagnostic strategy;Diet;Diet and Nutrition;dietary;Dietary Intervention;Environment;Etiology;Fatty acid glycerol esters;FDA approved;Financial cost;Foundations;Gene Modified;Genes;Genetic;genetic approach;Genetic Complementation Test;genetic risk factor;Genetic Transcription;genetic variant;Genotype;Glucose;gut microbiome;Homeostasis;Human;human model;human old age (65+);humanized mouse;Immune;Impaired cognition;Impairment;improved;In Vitro;in vitro Model;in vivo;Individual;induced pluripotent stem cell;Inflammation;innovation;insight;Intervention;ketogenic diet;ketogentic;Ketones;Ketosis;Knowledge;Lipids;Metabolic;Methods;Molecular;Mus;myelination;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neuroimmune;neuroinflammation;novel diagnostics;novel therapeutic intervention;novel therapeutics;Older Population;Oligodendroglia;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Peripheral;Persons;Pharmaceutical Preparations;preclinical study;Process;Production;Publishing;Regimen;Resistance;response;risk variant;Role;Signal Pathway;single-cell RNA sequencing;System;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;Tissues;transcriptomics;TREM2 gene;United States National Institutes of Health;Up-Regulation;Variant

PROJECT_TITLE: Investigating the combined role of APOE4 and ketogenic diets in Alzheimer's disease


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: IOWA CITY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative  Neurodegenerative diseases constitute an imminent health challenge, affecting tens of millions of Americans, and have been difficult to effectively treat due to limitations in our capability to study and perturb cellular processes in the brain. This proposal seeks to identify the mechanism of action of a neurotrophic (causing pro-survival and regenerative processes in the brain) small molecule which also affects how iron is used in the cell. This work will advance the molecule’s use as a biochemical tool for the study of the relationship between neurotrophic changes and iron levels and will further lead to new therapeutic targets in neurodegenerative disease, making the project relevant to the part of the NIH’s mission that pertains to expanding the knowledge base of medical science and reducing illness.

PI_NAMEs: EPP, JONATHAN RICHARD;WILLIAMS, FLORENCE JUDITH (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Address;Affect;Aging;Alleles;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;American;Amyloid beta-Protein;analog;Antibodies;apolipoprotein E-4;Apoptosis;Apoptotic;Binding;Biochemical;biochemical tools;Biological Assay;Biological Availability;blood-brain barrier crossing;Brain;brain tissue;Cell Culture Techniques;Cell Line;Cell Physiology;Cells;cellular targeting;Characteristics;Clinical Trials;Communities;Complex;crosslink;Data;density;design;Diazomethane;Disease Progression;drug development;Enzymes;Exhibits;Feedback;Ferritin;Foundations;Future;Goals;Growth;Health;Hippocampus;Homeostasis;Human;Huntington Disease;improved;insight;interest;Investigation;Ions;Iron;Iron-Binding Proteins;irradiation;Knock-in;Knock-in Mouse;knowledge base;Lead;Light;link protein;Lipids;Measures;Medical;Medicine;Membrane;Metals;Mission;Mitochondria;Modeling;Modernization;Molecular;Morphology;mouse model;Mus;Nerve Degeneration;Nerve Growth Factors;Neurodegenerative Disorders;neurogenesis;Neuronal Plasticity;Neurons;neurotrophic factor;new therapeutic target;Oral;oxidation;Oxidoreductase;Parkinson Disease;Pathologic;Pathology;Pharmaceutical Preparations;Phosphorylation;Post-Translational Protein Processing;Process;Production;protein expression;Proteins;Proteomics;Rattus;regenerative;Reporter;Resistance;response;Risk Factors;Role;scaffold;Science;Signal Transduction;Signal Transduction Pathway;small molecule;Stress;Structure;Sulfur;Surveys;tau-1;Therapeutic;therapeutic development;Time;Tissues;tool;Transgenic Mice;United States National Institutes of Health;Vertebral column;Western Blotting;Work

PROJECT_TITLE: A Mechanistic Foundation for the Iron Homeostasis Impacts and Neurotrophic Activity of trans-Banglene

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Social Determinants of Health;Substance Misuse;Suicide;Violence Research

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE  Alcohol use and suicidal thoughts and behaviors are strongly related, but the exact relationship between alcohol and suicide risk is poorly understood. Behavioral economic decision-making, such as rapid devaluing of delayed rewards (i.e., delay discounting), appears to be a common factor for increased alcohol use and suicidal thoughts and behaviors. The proposed research is to better understand how behavioral economic decision-making differs between individuals who use alcohol and those who use alcohol and have suicidal thoughts and behaviors.

PI_NAMEs: RZESZUTEK, MARK JUSTIN (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Acute;addiction;Adherence;Adult;Affect;alcohol abuse therapy;Alcohol consumption;alcohol demand;alcohol intervention;alcohol measurement;alcohol risk;alcohol use disorder;Alcohols;Behavior;Behavioral;behavioral economics;Bereavement;Career Choice;Cessation of life;Cognitive;completed suicide;Complex;Consumption;Control Groups;cost;Data;Decision Making;design;discounting;Dose;economic behavior;efficacy evaluation;experience;experimental study;Exposure to;Feeling suicidal;follow up assessment;Gestures;Heavy Drinking;Individual;Literature;Measures;Mediating;Mental Health;Methods;Modeling;Outcome;Overdose;overdose death;Participant;Pathology;Pathway interactions;Patient Self-Report;Persons;Pharmaceutical Preparations;Population;Predictive Factor;Prevalence;Price;Probability;Procedures;Process;prospective;Randomized;Recording of previous events;reinforcer;remote intervention;Research;Research Personnel;Rewards;Risk;Role;Sampling;Self Direction;Self-control as a personality trait;Series;Severities;skills;social;Social support;substance use treatment;success;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide rate;Time;Training;Uncertainty;Waiting Lists

PROJECT_TITLE: Examining the Relationship Between Ongoing Alcohol Use, Suicidal Thoughts and Behaviors and Related Constructs, and Behavioral Economic Decision-Making

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE The generation of virus-neutralizing antibodies is essential for recovery from infection and for the development of protective vaccines. This project will reveal the genetic basis for a previously unknown pathway for the generation of anti-viral antibodies.

PI_NAMEs: KANE, MELISSA E (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: adaptive immune response;Animal Model;Anti-Retroviral Agents;Antibodies;Antibody Formation;Antibody Response;Antibody-Producing Cells;Antigen-Presenting Cells;Antigens;B-Lymphocytes;BALB/cJ Mouse;C57BL/6 Mouse;Candidate Disease Gene;CD4 Positive T Lymphocytes;Cells;Code;cytokine;Data;Development;Disease;Dissection;Endosomes;forward genetics;Generations;Genes;Genetic;genetic approach;genetic makeup;genetic manipulation;Goals;HIV;Human;human disease;human model;I/LnJ Mouse;Immune Evasion;Immune response;Immunity;Immunoglobulin Class Switching;Immunoglobulin Switch Recombination;Immunologics;Inbred Mouse;Inbred Strain;Inbred Strains Mice;Individual;Infection;Inherited;Innate Immune System;insight;Interferon Type II;Investigation;Knowledge;Link;loss of function mutation;Lymphoid;Maps;Mediating;Molecular;Mouse Mammary Tumor Virus;mouse model;Murine leukemia virus;Mus;Names;neutralizing antibody;novel;novel therapeutic intervention;pathogen;Pathway interactions;Phenotype;Play;positional cloning;prevent;Production;Proteins;Radiation;radioresistant;Recovery;Resistance;resistance allele;resistance mechanism;response;Retroviridae;Signal Pathway;Signal Transduction;TLR7 gene;tool;Vaccines;Viral;Viral Antibodies;viral detection;Virus;Virus Diseases

PROJECT_TITLE: Genetic basis for interferon-gamma-independent antiviral antibody production

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


NIH_SPENDING_CATS: Asthma;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: We propose studies to investigate the mechanisms by which eosinophils contribute to antibacterial host defenses during opportunistic pneumococcal bacterial infection. These studies are relevant to public health because they will provide mechanistic insight into immune responses in hosts with allergic asthma during synergistic viral and bacterial co-infection. Identified mechanisms may provide novel insights into unforeseen targets of intervention that may be broadly applicable.

PI_NAMEs: SAMARASINGHE, AMALI  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Adult;Allergic;Allergic inflammation;Alveolar Macrophages;Anti-Bacterial Agents;antiviral immunity;arm;Asthma;asthmatic;asthmatic patient;Bacteria;Bacterial Infections;Bacterial Pneumonia;bactericide;Biology;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cessation of life;Chronic;Clinical Data;clinically relevant;co-infection;Complex;Data;Effector Cell;Elements;eosinophil;Eosinophil cationic protein;Eosinophilia;eosinophilic asthma;Excess Mortality;expectation;experimental study;extracellular;Extrinsic asthma;Failure;fungus;Goals;Hospitalization;Host Defense;human pathogen;Immune;Immune response;Immune system;Immunity;Immunobiology;immunoreaction;immunoregulation;improved;in vivo;Infection;Inflammation;Influenza;Influenza A virus;Informal Social Control;Innate Immune System;innovation;insight;Intervention;Invaded;Knowledge;Laboratories;Leukocytes;Lower Respiratory Tract Infection;Lung;lung injury;Mediating;Mediator;Methods;Modeling;Morbidity - disease rate;mortality;mouse model;Mucosal Immune System;Mucosal Immunity;Mucous Membrane;Mus;Natural Immunity;new therapeutic target;novel;opportunistic pathogen;Outcome;pandemic influenza;pathogen;pathogenic bacteria;Pathogenicity;Pathology;Pathway interactions;Patients;Phagocytes;Phase;Phenotype;Physiological;Pneumococcal Infections;Pneumonia;prevent;Proteins;Public Health;Pulmonary Inflammation;Research;respiratory pathogen;Respiratory Tract Infections;respiratory virus;response;Role;Skin;Spanish;Streptococcus pneumoniae;swine flu;T cell response;Testing;Therapeutic;Tissues;uptake;Viral;Virus Diseases;Work

PROJECT_TITLE: Eosinophils as Effectors of Antibacterial Immunity in the Lungs

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: PROJECT NARRATIVE Extracellular vesicles (EVs) serve as mediators for cell-cell communication to maintain tissue homeostasis and contribute to age-related pathologies, in which angiogenesis is impaired. Given that Y-RNAs are one of the most abundant EV-enclosed non-coding RNAs and the levels of Y-RNAs correlate with age-related cardiovascular diseases, this proposal seeks to understand the role of EV-enclosed Y-RNAs in endothelial cell (EC) senescence and age-related decline in angiogenesis. If this study proves that Y-RNA in EC-derived EVs inhibits EC senescence and reverses the age-dependent impairment of angiogenesis, this work will lead to the development of new and better EV-based strategies for age-related diseases.

PI_NAMEs: MAMMOTO, AKIKO  (contact);MAMMOTO, TADANORI

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Adipose tissue;age related;age related decline;Age related pathologies;age-related disease;aged;Aging;aging population;aging related;aging related disease;angiogenesis;Animals;Antiinflammatory Effect;Blood capillaries;blood vessel development;Blood Vessels;Cardiovascular Diseases;cell age;Cell Aging;Cell Communication;Cell Senescence Induction;Cells;Chronic Disease;Chronic lung disease;Data;Development;DNA Synthesis Inhibition;Endothelial Cells;Endothelium;exosome;extracellular;extracellular vesicles;Gel;Genes;Genetic Transcription;Goals;Growth;Homeostasis;Human;Hydrogels;Immune System Diseases;Impairment;Implant;In Vitro;in vitro activity;innovation;knock-down;Lipids;Lung;Malignant Neoplasms;Mediating;Mediator;MicroRNAs;migration;Mus;Natural regeneration;Nucleic Acids;old mice;Organ;organ growth;organ regeneration;Osteoporosis;overexpression;Pathogenesis;pathological aging;Physiology;Plasma;Play;Predisposition;pro-aging;Proteins;regenerative;repaired;Reporting;RNA;RNA-Binding Proteins;Role;senescence;senescence associated secretory phenotype;senescent cell;Signal Transduction;subcutaneous;Tissues;Untranslated RNA;Work

PROJECT_TITLE: Endothelial extracellular vesicles in aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PUBLIC HEALTH RELEVANCE Glioblastoma is the most common primary brain tumor in adults, is essentially incurable, and is associated with significant morbidity. In this project, we will evaluate how a potent drug (Brigimadlin) can be used to most effectively treat patients with glioblastoma, and we will test why a subset of these tumors, with a specific genetic alteration called MDM2 amplification, are especially sensitive to the drug.

PI_NAMEs: SARKARIA, JANN N. (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: ABCG2 gene;Adult;Aftercare;Apoptosis;Binding;Blood - brain barrier anatomy;Brain;Brain Neoplasms;Cell Cycle;Cell Cycle Progression;Cell Line;Cellular Stress;chemotherapy;Clinical;clinical development;Collaborations;Complex;Convection;Coupled;Critical Pathways;cytotoxic;Data;Defect;DNA Crosslinking;DNA Damage;DNA Repair;DNA Repair Gene;DNA Repair Pathway;DNA Sequence Alteration;Dose;Double Minutes;Drug Delivery Systems;Drug Efflux;efflux pump;Event;Exclusion;Fanconi Anemia pathway;Genes;Genetic Transcription;Genomics;Genotoxic Stress;genotoxicity;Glioblastoma;Grant;Heel;homologous recombination;Hour;In complete remission;in vivo;Induction of Apoptosis;inhibitor;inhibitor therapy;Knockout Mice;Malignant - descriptor;Malignant Neoplasms;MCL1 gene;Mediating;Modeling;Morbidity - disease rate;Mus;Mutation;novel;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Primary Brain Neoplasms;pro-apoptotic protein;promoter;Proteins;public health relevance;Publishing;Radiation;Recovery;Refractory;repaired;Reporting;response;restoration;Sarcoma;Signal Transduction;Stress;Testing;Therapeutic;therapeutic target;TP53 gene;Transcription Coactivator;Transcriptional Activation;transcriptome sequencing;tumor;Tumor Suppressor Proteins;tumorigenesis;Ubiquitination;Up-Regulation;Western Blotting;Withholding Treatment

PROJECT_TITLE: Maximizing the efficacy of MDM2 inhibitor therapy for MDM2-amplified glioblastoma

STUDY_SECTION: MCTC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics C Study Section [MCTC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Neurodegenerative;Neurosciences;Nutrition;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative Cognitive impairment manifests in later life from the accrual of exposures in the preceding decades, which also exhibit disparities by race. There is consistent evidence that mid- and late-life diet patterns are linked to cognitive decline, but the underlying pathways are incompletely understood. In this proposal, we will test the hypothesis that gut microbiome-related metabolites are associated with subsequent cognitive impairment, and influence the rate of conversion of amyloid- and vascular-related dementia; these studies will improve our ability to identify individuals at risk, identify potential reasons for racial differences in those risks, and clarify the role of gut microbiome-related metabolites in cognitive function over the lifespan.

PI_NAMEs: KIMBERLY, WILLIAM TAYLOR (contact)

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Address;Adult;Age;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Biological Markers;biomarker identification;Black Populations;Black race;Blood;Blood specimen;Blood Vessels;Brain;brain magnetic resonance imaging;Cerebral small vessel disease;Cognition;Cognitive;cognitive enhancement;cognitive function;cognitive testing;cohort;Cohort Studies;Communities;Coronary Artery Risk Development in Young Adults Study;Data;Dementia;demographics;design;Diabetes Mellitus;Diet;Dietary intake;Dietary Practices;disease phenotype;disorder risk;Disparity;Education;Engineering;Epidemiology;Exhibits;Future;Geography;gut microbiome;gut microbiota;Health behavior;health disparity;high risk;Hypertension;imaging biomarker;Impaired cognition;improved;Incidence;Individual;insight;Interdisciplinary Study;Intervention;Intervention Studies;late life;Lead;life span;Link;Logistic Regressions;Magnetic Resonance Imaging;Measures;Mediation;Mediator;metabolomics;Methods;microbial;middle age;Modeling;Modification;molecular marker;multi-racial;neuroimaging;Neurological disability;novel;Observational Study;Outcome;Participant;Pathogenesis;Pathway interactions;Pattern;personalized medicine;Phenotype;Plasma;Positron-Emission Tomography;primary outcome;Proxy;Race;racial difference;racial disparity;Reasons for Geographic And Racial Differences in Stroke;Recurrence;Reporting;Research;Research Design;Research Personnel;Risk;Risk Factors;Role;Sampling;secondary analysis;sex;Socioeconomic Factors;Source;Stroke;Testing;Therapeutic;vascular cognitive impairment and dementia;White Matter Hyperintensity

PROJECT_TITLE: Gut microbiome-related metabolites and cognitive impairment

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]