ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

PHR: Project Narrative Perturbation of the Hedgehog (HH) pathway and activation of glioma-associated oncogene (GLI), a dedicated transcription factor in the HH pathway, is responsible for approximately 30% of medulloblastoma. The proposed project has the potential to improve public health by elucidating the novel role of O-GlcNAcylation in regulating GLI functions in the HH pathway, which will eventually lead to better diagnosis and treatment of medulloblastoma. The proposed work will utilize laboratory-based science to advance strategies for overcoming radiochemoresistance in medulloblastoma.

PI_NAMEs: PEI, HUADONG  (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: Address;Affect;Antibodies;Biochemical;biophysical techniques;cancer cell;cancer therapy;Cell Physiology;Cells;chemoradiation;Childhood Brain Neoplasm;Dedications;design;detection method;Development;Developmental Process;Diagnosis;Disease;effective therapy;Ensure;Erinaceidae;experimental study;extracellular;FRAP1 gene;Genetic Transcription;Genetically Engineered Mouse;GLI gene;GLI2 gene;Glioma;Glucose;Goals;Growth;Homeostasis;improved;In Vitro;in vivo;insight;Investigation;Knowledge;Laboratories;Ligands;Link;Mass Spectrum Analysis;Mediating;Medulloblastoma;Modeling;Modification;Molecular;mortality;multidisciplinary;novel;novel marker;novel therapeutics;Nutrient;nutrition;O-GlcNAc transferase;Oncogene Activation;Oncogenes;Pathway interactions;patient derived xenograft model;Patients;personalized medicine;Physiology;Play;postnatal;Proteins;Proteome;Proteomics;Public Health;Regulation;Research;response;Role;Science;sensor;Signal Transduction;smoothened signaling pathway;Testing;Therapeutic;therapeutic target;transcription factor;Work

PROJECT_TITLE: Regulation of the Hedgehog pathway and Medulloblastoma response to radiochemotherapy

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: NARRATIVE: Cognitive aging across the lifespan has profound implications for the health, quality of life and productivity of society. The superimposed risk of Alzheimer's disease increases with more advanced age. The proposed research program constitutes a major reevaluation of the methods and goals of the study of cognitive aging that should provide major new, integrative, and perhaps simplifying, insights into the neural basis of the most important and central features of cognitive aging and into the preclinical brain changes leading up to AD.

PI_NAMEs: HABECK, CHRISTIAN GEORG;STERN, YAAKOV  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Adult;Age;age difference;age effect;age related;aged;Aging;Alzheimer's Disease;Alzheimer's disease risk;Amyloid;Appearance;Atrophic;base;Behavior;behavior change;Behavioral;Brain;brain volume;Clinical;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive function;cognitive performance;cognitive reserve;cognitive task;cognitive testing;cohort;Core-Binding Factor;Data;Dementia;dementia risk;Deposition;Disparate;Education;Elderly;Episodic memory;Evaluation;follow-up;Functional Imaging;Functional Magnetic Resonance Imaging;Funding;Gait;Genetic;Goals;Grant;gray matter;Health;human old age (65+);Image;imaging approach;Incidence;Individual;insight;Intelligence;Life;life span;Liquid substance;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;Mediator;Methods;mild cognitive impairment;Modeling;Multimodal Imaging;Nature;neural;neural correlate;neural network;neuroimaging;Outcome;Participant;Pathology;Pattern;Performance;Personality;Persons;Phase;Phenotype;polygenic risk score;Positron-Emission Tomography;pre-clinical;predictive modeling;Process;Productivity;prognostic;programs;Quality of life;Research;Research Personnel;Resources;Rest;Series;sex;social;Societies;Speed;Statistical Data Interpretation;structural imaging;Structure;tau Proteins;Testing;Thick;Time;Vocabulary;white matter;White Matter Hyperintensity

PROJECT_TITLE: Exploring Cognitive Aging Using Reference Ability Neural Networks

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Alzheimer’s disease, a disorder characterized by progressive memory loss and cognitive deficits and affecting tens of millions of people globally, is first pathologically evident among a subset of cells in specific brain regions including the hippocampal-entorhinal system critical for learning and memory. Aging is a major risk factor for Alzheimer’s disease and age related changes occur throughout adulthood concurrent with disease progression, complicating our understanding of the molecular and cellular events underlying the etiology of Alzheimer’s disease as opposed to normal aging. We therefore propose to use cutting edge technologies to investigate the cell type specific molecular mechanisms and gene regulatory networks underlying Alzheimer’s disease and aging in the human and non-human primate brain.

PI_NAMEs: HUTTNER, ANITA JULIANE;SESTAN, NENAD  (contact);STRITTMATTER, STEPHEN M

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Adopted;Adult;Affect;Age;age related changes;aged;Aging;aging related disease;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease risk;Anatomy;Area;Atlases;Autopsy;base;Biological;Biological Assay;Biological Models;Biological Process;Brain;Brain region;Cell Differentiation process;Cell Nucleus;cell type;Cells;Censuses;Cerebrum;Characteristics;Chromatin;Cognitive deficits;Communities;Custom;Data;Data Analyses;data dissemination;Dementia;dentate gyrus;Disease;Disease Progression;entorhinal cortex;Etiology;Event;Exhibits;Gene Expression;Gene Expression Profile;gene network;gene regulatory network;Generations;Genes;Genomics;granule cell;Hippocampal Formation;hippocampal subregions;Hippocampus;Human;human disease;insight;Learning;life span;Macaca;Macaca mulatta;Mammals;Measures;Medial;Mediating;medical schools;Memory;Memory Loss;Modeling;Molecular;Molecular Profiling;multiple omics;Mus;neural;Neuroglia;Neuronal Differentiation;Neurons;neuropathology;new therapeutic target;nonhuman primate;normal aging;Nuclear;Nuclear RNA;Pathologic;Pathology;Persons;Phenotype;Population;Primates;Printing;Process;Quality Control;Regulatory Element;Research;resilience;Resolution;Resources;response;sex;single cell genomics;single nucleus RNA-sequencing;Specificity;Standardization;System;Techniques;Technology;Temporal Lobe;Testing;Tissue Sample;transcriptome sequencing;Transposase;Validation;Visualization;young adult

PROJECT_TITLE: Molecular Diversity Among Hippocampal and Entorhinal Cells in Aging and Alzheimer's Disease

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: This project will identify blood-based epigenetic aging biomarkers predicting risk of mild cognitive impairment (MCI), Alzheimer’s disease and related dementias (ADRD), and brain aging. These biomarkers can be used to identify older adults early in the ADRD disease course to potentially prevent irreversible cognitive and functional decline. The proposed research will support NIA’s public health mission by addressing the NIA 2020- 2025 Strategic Directions for Research goals of understanding how “molecular bases of changes associated with aging contribute to the development and course of age-related dementia” and identifying “biological and clinical markers for early detection of cognitive decline, MCI, and AD.”

PI_NAMEs: SHADYAB, ALADDIN  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: accelerated epigenetic aging;Acceleration;Address;African American;Age;age related;age related decline;Aging;aging biomarker;aging brain;Alzheimer's disease related dementia;Alzheimer's disease risk;base;Behavior;Biological Aging;Biological Markers;biomarker identification;Blood;Brain;brain health;Brain region;brain volume;Cardiovascular Diseases;Characteristics;Chronology;Clinical Markers;Clinical Trials;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive performance;cohort;Cohort Studies;Data;data resource;Dementia;dementia risk;Development;Disease;DNA;DNA Methylation;early detection biomarkers;Early Diagnosis;Epigenetic age;epigenetic aging;epigenetic clock;Epigenetic Process;epigenome-wide association studies;Episodic memory;ethnic diversity;Ethnic Origin;experience;follow-up;functional decline;Funding;Future;Genome;genome-wide;Genotype;Goals;high risk;Hispanic Women;Impaired cognition;improved;Individual;innovation;inter-individual variation;Intervention;Investments;Knowledge;late life;Lesion;Life Style;Measures;Memory;men;Methylation;mild cognitive impairment;Mission;Molecular;Monitor;neuroimaging;novel;older adult;Outcome;Peripheral;Persons;Phenotype;Physiological;Population;Positioning Attribute;predictive marker;preservation;Prevalence;prevent;Process;Psychosocial Factor;Public Health;Race;racial diversity;rate of aging;Research;Resources;Risk;risk prediction;Role;sociodemographics;Symptoms;therapeutic target;Tissues;Treatment Efficacy;Ventricular;Visit;white matter;Woman;Women's Health

PROJECT_TITLE: Epigenetic Aging Biomarkers of Mild Cognitive Impairment, Alzheimer's Disease and Related Dementias, and Brain Aging

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Sleep disruption affects millions of older Americans and is associated with an increased risk of Alzheimer’s disease (AD); moreover adults with AD have increased sleep disruption. Using an innovative cross-species, human and fly translational approach, we will identify novel gene targets underlying the bi-directional relationship between AD and sleep disruption. This will pave the way for new treatments to prevent the negative impact of sleep disruption on the risk of AD, and improve sleep disruption in patients with AD, resulting in a sustained impact on the health of millions of older Americans at risk of, or suffering from, Alzheimer’s disease.

PI_NAMEs: LIM, ANDREW ;SHAW, PAUL J (contact);SHULMAN, JOSHUA M

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Adult;Affect;Aging;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;American;Amyloid beta-Protein;Autopsy;Blood;Brain;Candidate Disease Gene;candidate identification;causal variant;circadian pacemaker;Clinical;Cognition;Cognitive;cognitive testing;cohort;Data;Dementia;density;differential expression;Dissection;Drosophila genus;drug development;Experimental Models;experimental study;fly;Gene Expression;Gene Modified;Gene Targeting;Genes;Genetic;genetic manipulation;genomic data;Goals;gray matter;Health;Human;Impaired cognition;improvement on sleep;indexing;Inferior frontal gyrus;innovation;Investigation;knock-down;Lateral;Link;Mass Spectrum Analysis;Measures;Mediating;Memory;Mendelian randomization;model organism;Molecular;Neurofibrillary Tangles;Neurons;neurotoxicity;novel;older adult;overexpression;Participant;Pathologic;Pathology;Pilot Projects;Predisposing Factor;Prefrontal Cortex;prevent;Proteome;Proteomics;Resources;Risk;Role;Sampling;Sleep;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;tau Proteins;Tauopathies;transcriptome;transcriptome sequencing;transcriptomics;translational approach;Validation;validation studies

PROJECT_TITLE: Bidirectional interactions between sleep and Alzheimer's disease: Functional dissection of the brain transcriptome in humans and Drosophila

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Mental Health;Microbiome;Natural Products;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Narrative The purpose of this grant application is to dissect the biological underpinnings of the heterogeneity of aging brain’s susceptibility to postoperative delirium, with a focus on gut microbiota and metabolites. The outcomes of this proposal will fill in the critical gaps in this under-investigated area to provide novel mechanistic insights and potential therapeutic targets.

PI_NAMEs: SHEN, SHIQIAN  (contact);WANG, CHANGNING ;ZHANG, CAN MARTIN

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Address;age group;Aging;aging brain;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Anesthesia procedures;Applications Grants;Area;Attention;Bacteria;Behavior;Behavioral Assay;Binding;Biogenesis;Biological;Brain;Categories;Clinical;clinically significant;Clostridium;Cognitive deficits;cognitive function;Data;Delirium;Dementia;designer receptors exclusively activated by designer drugs;Development;Disease susceptibility;Dose;Effectiveness;Elderly;Exhibits;Face;Feces;Gastrointestinal tract structure;Genetic;Germ-Free;Grant;gut microbiota;healthy aging;Heterogeneity;high risk;Hippocampus;human old age (65+);Incidence;individual patient;Indoles;innovation;insight;Interneuron function;Interneurons;Kinetics;Label;Mediating;Mental Health;metabolomics;Metagenomics;Microbe;Mitochondria;mortality;multiple omics;Mus;mutant;Mutant Strains Mice;Neurodegenerative Disorders;Neurologic;Neurons;Newly Diagnosed;novel;old mice;older patient;Older Population;Operative Surgical Procedures;Orthopedic Surgery;Outcome;Parkinson Disease;Pathogenesis;Patients;PET/CT scan;physical conditioning;Play;Postoperative Complications;postoperative delirium;Predisposition;prevent;Prevention;Propionic Acids;prospective;protective effect;radiotracer;Research;resilience;Resistance;response;Risk;Role;Serum;side effect;Supplementation;Testing;Therapeutic Effect;therapeutic target;Time;tool;transcriptomics;Variant;X-Ray Computed Tomography

PROJECT_TITLE: Gut Microbiota Underlies the Heterogeneity of Aging Brain's Susceptibility to Postoperative Delirium

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Gene Therapy;Genetics;Nanotechnology;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: FARGO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTH DAKOTA STATE UNIVERSITY

ORG_STATE: ND

PHR: PROJECT NARRATIVE: Alzheimer’s disease (AD) is the most common type of dementia in the elderly, which accounts for 60-80% of cases. Currently, an estimated 5.7 million Americans of all ages have AD. Apolipoprotein E (APOE) plays a critical role in maintaining synaptic plasticity and neuronal function by controlling lipid homeostasis, with the APOE2 allele having a superior function. The APOE2 has been found to be more prevalent among centenarians and associated with decreased susceptibility to AD. Studies on the role of the APOE2 in relation to AD suggest that APOE2 is neuroprotective and is positively associated with cognitive functions in aging. Therefore, increasing APOE2 level in the brain is an effective therapeutic strategy for AD. Although gene therapy possesses immense potential of treating various neurodegenerative diseases including AD, its clinical application is limited mainly due to lack of safe and effective vectors that can efficiently deliver the therapeutic gene across the blood brain barrier. The long-term goal of the proposed research is to design a gene delivery carrier for efficient delivery of pDNA encoding APOE2 to brain for prevention and treatment of AD. The studies will be conducted in vitro and in vivo in Wild Type, APOE-knockout, amyloid AD APP/PS1 and tau model PS19 mice.

PI_NAMEs: KANEKIYO, TAKAHISA ;SINGH, JAGDISH  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: abeta accumulation;Abeta clearance;abeta deposition;Age;Age Months;Age-associated memory impairment;aged;Aging;aging related;Alleles;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease therapy;American;Amyloid;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-4;APP-PS1;Astrocytes;Biodistribution;Biological Assay;biomaterial compatibility;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier function;Brain;brain endothelial cell;Cells;Centenarian;Cerebral endothelium;Chitosan;clinical application;clinically relevant;Coculture Techniques;Cognitive;cognitive function;Coupled;cytotoxicity;Dementia;design;Development;Disease;Drug Kinetics;effective therapy;Elderly;Encapsulated;Endosomes;Environmental Risk Factor;Event;Film;Gene Delivery;gene delivery system;gene therapy;Genes;Genetic;genetic risk factor;genetic variant;Genotype;Goals;Hemolysis;Homeostasis;Human;Hydration status;Impaired cognition;improved;In Vitro;in vivo;Individual;Intercellular Fluid;Knock-out;Knockout Mice;late life;Late Onset Alzheimer Disease;Light;lipid nanoparticle;Lipids;Liposomes;Measures;Mediating;Micelles;Microdialysis;model design;Modeling;mouse model;Mus;nanoparticle;Nerve Degeneration;Nervous System Disorder;neurobehavior;neuroblastoma cell;Neurodegenerative Disorders;neurofilament;Neurons;neuroprotection;non-viral gene delivery;Non-Viral Vector;Organ;overexpression;Particle Size;Pathogenesis;Pathology;Pathway interactions;penetratin;Penetration;Peptides;Phenotype;Plasma;plasmid DNA;Play;Porifera;Predisposition;Prevention;Property;protective effect;Proteins;Protons;rabies virus glycoprotein G;receptor;Research;Role;Sampling;Surface;synaptic function;Synaptic plasticity;System;tau Proteins;tau-1;Techniques;Tetanus Toxin;tetanus toxin fragment C;TFRC gene;Therapeutic;Therapeutic Effect;therapeutic gene;therapeutically effective;Thinness;Toxic effect;transcytosis;Transfection;Transferrin;uptake;vector;Wild Type Mouse;zeta potential

PROJECT_TITLE: Enhanced APOE2 Expression into Brain for Therapeutic Strategy for Alzheimer's Disease

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Project Narrative Risk for financial exploitation has both been associated with diminished cognitive abilities (e.g., reduced executive functioning), Alzheimer's Disease, depressive symptoms, and a range of demographic variables (e.g., socioeconomic status, sex, and ethnicity). Yet, it remains unclear whether age-related differences in neural processing of social and nonsocial rewards underlie these relationships. Understanding the role of altered reward-processing mechanisms will help establish a foundation for future work aimed at characterizing and mitigating risk for financial exploitation in older adults.

PI_NAMEs: SMITH, DAVID VICTOR (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: 21 year old;Adult;Age;age difference;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Anterior;Attenuated;Brain;Brain region;cingulate cortex;cognitive ability;cognitive function;Corpus striatum structure;Data;Decision Making;Dementia;depressive symptoms;Economics;emotional functioning;Ethnic Origin;executive function;Exhibits;experience;experimental study;Family;financial decision making;financial exploitation;Foundations;Fraud;Friends;Future;Goals;Health;health assessment;Health Status;Impaired cognition;Individual;information processing;insight;life span;Link;low socioeconomic status;mild cognitive impairment;Nature;neural;Neurocognitive;neuroimaging;neuromechanism;Neuropsychology;novel;older adult;Parietal;Participant;Patient Self-Report;Pattern;peer;Persons;Prefrontal Cortex;Process;Questionnaires;recruit;response;Rest;reward processing;Rewards;Risk;Risk Assessment;Risk Factors;risk mitigation;Role;Sampling;sex;social;social engagement;Social Environment;social influence;Social Network;Social support;sociodemographic factors;sociodemographic variables;Socioeconomic Status;System;Testing;Time;Translations;Trust;Vascular Cognitive Impairment;Vascular Dementia;Visit;Vulnerable Populations;white matter;White Matter Hyperintensity;willingness;Withdrawal;Work;young adult

PROJECT_TITLE: Social Reward Processing Across the Lifespan: Identifying Risk Factors for Financial Exploitation

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Alzheimer’s disease (AD) causes progressive loss of memory, for which there is no cure. A growing understanding of memory impairment in AD suggests that alterations at the genetic and cellular levels contribute to circuit dysfunction. Knowledge gained from our proposed studies will advance the understanding of the key neural circuits that modulate vulnerable networks during early AD, and guide new therapeutic directions by selectively targeting these modulatory circuits for treating memory loss associated with AD.

PI_NAMEs: SONG, JUAN  (contact)

PROJECT_TERMS: abeta deposition;Acute;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Anatomy;Behavioral;Cell Nucleus;Chronic;Clinical;Code;Data;density;dentate gyrus;Dentate nucleus;Disease;Disease Progression;Electrophysiology (science);entorhinal cortex;Exhibits;experimental study;Fiber;FOS gene;Functional disorder;Genetic;Glutamates;granule cell;Hippocampus;Human;Hypothalamic structure;Impairment;improved;in vivo;Knowledge;Lateral;Measures;Memory;Memory impairment;Memory Loss;memory retrieval;Mus;neural circuit;neurogenesis;Neurons;novel;novel therapeutics;Pathway interactions;Performance;Photometry;Play;Positioning Attribute;Rabies;Slice;spatial memory;Synapses;System;Testing;transmission process

PROJECT_TITLE: Glutamatergic neural circuit modulation for treating Alzheimer’s disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN-R]


ORG_CITY: BALTIMORE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Alzheimer's disease impacts a large number of individuals. One to the pathological features of this disease are neurofibrillary tangles (NFTs) that occur in the cytoplasm of neurons and are made up of an unfolded protein called tau. NFT occur initially in a region of the brained termed the entorhinal cortex, then “spread” to other limbic and association areas over more than a decade; this spread corresponds to the clinical symptoms of the disease and correlates with the destruction of neurons. Evidence suggests that this misfolded protein is transferred from neuron to neuron, and how this occurs is an important and central question that remains unanswered. Our studies have identified receptor molecules on the surface of neurons that are capable to binding tau and mediating its internalization into neurons. This grant will investigate detailed mechanisms of how these receptors guide this misfolded protein to the cytoplasm of the cell to trigger formation of more neurofibrillary tangles and thereby propagate formation of this disease.

PI_NAMEs: HYMAN, BRADLEY T.;STRICKLAND, DUDLEY K. (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease patient;antagonist;Apolipoprotein E;Area;Axon;Binding;Binding Proteins;Brain;Brain region;Cell Line;Cell surface;Cells;Characteristics;Clinical;Collaborations;Complex;Cryoelectron Microscopy;Cytoplasm;Data;defined contribution;Disease;Disease Progression;Elements;Endocytosis;Endosomes;entorhinal cortex;Environmental Risk Factor;experimental study;Genetic;genetic risk factor;Grant;Human;in vivo;Individual;Laboratories;LDL-Receptor Related Protein 1;LDL-Receptor Related Proteins;Lead;Ligand Binding Domain;Ligands;Lipoprotein (a);Lipoprotein Receptor;Lysosomes;Macroglobulins;MAPT gene;Mediating;misfolded protein;monomer;mouse model;mutant;Mutation;neural;Neural Pathways;Neuroanatomy;Neurofibrillary Tangles;neuron loss;Neurons;neuropathology;paired helical filament;Paper;Pathogenicity;Pathologic;Pattern;Phosphorylation;Process;Protein Isoforms;Proteins;Publishing;rare variant;receptor;receptor internalization;Recording of previous events;Residual state;Role;Rupture;Signal Transduction;superresolution microscopy;Surface;Symptoms;Synapses;System;tau aggregation;tau interaction;tau Proteins;tau-1;Time;trafficking;uptake;Work

PROJECT_TITLE: LRP1-tau interactions and Alzheimer Disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

PHR: Disease-modifying therapy for Alzheimer’s disease (AD) is a massive and urgent unmet medical need. Cognitive failure stems most directly from neuronal synapse loss during mild cognitive impairment and mild AD. Innate immune mechanisms release complement proteins, which then tag specific neuronal synapses for removal. Here, we seek to define the molecular mechanisms at specific neuronal synapses which instruct the recruitment of complement proteins to trigger synapse loss. By understanding synaptic clearance mechanisms, we aim to develop the means to preserve synaptic number and function in AD.

PI_NAMEs: STRITTMATTER, STEPHEN M (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: abeta oligomer;Affinity;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease therapy;Amyloid beta-Protein;Automobile Driving;Autopsy;axon injury;Binding;Binding Proteins;Binding Sites;Biochemical;Biological Markers;Brain;Cell Culture Techniques;Cell surface;Cells;Cessation of life;Cognitive;Complement;Complement 1q;Complementary DNA;Complex;Coupled;Coupling;Data;Dementia;density;Development;Disease;DLG4 gene;Excision;experimental study;expression cloning;Failure;Functional disorder;Gene Chips;Genes;Genetic;Genetic study;genome-wide;Gliosis;hand dysfunction;Heterozygote;Human;Hydrogels;immune activation;immune clearance;Immune System Diseases;Impaired cognition;In Vitro;in vivo;Individual;Inflammatory;innate immune mechanisms;Innate Immune System;Interruption;Investigation;Knock-in;Knock-in Mouse;Knockout Mice;Link;Measures;Mediating;Mediator;Medical;Membrane;Membrane Proteins;Memory;Microglia;mild cognitive impairment;misfolded protein;Modeling;Molecular;Monitor;mouse model;Mus;Natural Immunity;Nerve Degeneration;neural;neuron loss;Neuronal Dysfunction;Neurons;neurotransmission;novel;overexpression;Pathologic;Pathology;Pathway interactions;Peptides;pharmacologic;Phase;Phase Transition;polypeptide;Positron-Emission Tomography;postsynaptic;preservation;Prevalence;prevent;Prevention;Process;Production;Proteins;Reaction;receptor;recruit;Regulation;response;Role;sample fixation;Signal Pathway;Signal Transduction;Site;Specificity;stem;stoichiometry;Symptoms;Synapses;System;tau Proteins;Testing;Therapeutic;Transgenic Organisms

PROJECT_TITLE: Synaptic selectivity for microglial-mediated damage in Alzheimer's Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: NARRATIVE Abnormal circadian rhythms are associated with Alzheimer’s disease (AD), but it is unclear whether and how the central circadian clock in the hypothalamus contributes to cognitive functions. We will address these questions using novel animal models and methods. The study will provide insights into the mechanism of AD-related dementia (ADRD) and lay groundwork for harnessing the circadian rhythm to treat ADRD

PI_NAMEs: SUN, ZHENG  (contact)

PROJECT_TERMS: Address;aging population;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Animal Genetics;Animal Model;Arrhythmia;Body Temperature;Brain region;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Cognitive;Cognitive deficits;cognitive function;Data;Exposure to;feeding;Functional disorder;gamma-Aminobutyric Acid;Genes;Genetic;genetic approach;Genetic Models;Hormonal;Human;Hyperactivity;Hypothalamic structure;Impaired cognition;insight;Intervention;Jet Lag Syndrome;Light;Memory;Memory impairment;Memory Loss;Methods;Modeling;Modernization;Molecular;molecular clock;Motor Activity;mouse model;Mus;neural;neural circuit;Neurodegenerative Disorders;Neurons;neuroregulation;neurotransmission;novel;Nuclear Receptors;Patients;Pattern;Periodicity;Phase;restoration;Schedule;shift work;Signal Transduction;social;Societies;Structure of paraventricular nucleus of thalamus;suprachiasmatic nucleus;Synapses;Testing;tool;Wild Type Mouse

PROJECT_TITLE: Circadian clock gene Rev-erb in memory dysfunction in Alzheimer's disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_DEPT: PSYCHIATRY

PHR: Narrative Alzheimer's disease is highly heterogeneous presenting sex-differentiated characteristics. Understanding the impact of sex differences on the trajectories of brain aging and AD is critical for individualized prevention and treatment of AD. We will employ integrative experimental and analytical approach to generate and analyze high-dimensional omic data in multiple relevant tissues to identify sex-specific multi-omic signatures and drug targets.

PI_NAMEs: SUNG, YUNJU  (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: age difference;aging brain;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;apolipoprotein E-4;Astrocytes;Automobile Driving;Biological;Biological Markers;Biology;Brain;causal variant;Cells;Cerebrospinal Fluid;Characteristics;Clinic;Clinical;clinical translation;Collection;Communities;connectome;CRISPR/Cas technology;Data;data integration;data sharing;Diagnostic;Disease;Disease Progression;disorder risk;DNA Methylation;Drug Targeting;epigenomics;Ethnic Origin;Etiology;FDA approved;Female;Functional disorder;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Genetic;genetic architecture;Genetic Markers;genetic variant;Genetic Variation;genome wide association study;genome-wide;Genomics;Genotype-Tissue Expression Project;Germ Cells;Goals;high dimensionality;high risk;Human;individualized medicine;individualized prevention;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inherited;Innate Immune Response;insight;Interdisciplinary Study;Investments;Knowledge Portal;Life Expectancy;lipidomics;Lysosomes;male;Maps;Memory;Mendelian randomization;metabolomics;Methylation;Microglia;Molecular;molecular marker;Molecular Profiling;Multiomic Data;multiple omics;Nerve Degeneration;neuroimaging;Neurons;new therapeutic target;novel;Participant;Pathology;Pathway interactions;Pharmaceutical Preparations;Plasma;predictive modeling;preventive intervention;Productivity;Proteins;proteomic signature;Proteomics;Quantitative Trait Loci;Race;Reporting;Reproducibility;Request for Applications;Research;Resources;response;risk variant;Role;Sampling;Series;sex;Sex Differences;Sex Differentiation;specific biomarkers;stem cell model;tau Proteins;Technology;Therapeutic;Tissues;transcriptomics;TREM2 gene;United States National Institutes of Health;Universities;virulence gene;Washington;Woman

PROJECT_TITLE: Sex-specific Molecular Profiling to Understand Pathology and Identify Causal Genes and Drug Targets for Alzheimer's Disease


ADMINISTERING_IC: HG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Genetics;Hematology;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_DEPT: MISCELLANEOUS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Single-cell CRISPR screens are a new high-throughput experimental approach which can deepen our understanding of how genes and regulatory elements interact in biological networks. We propose to develop computational tools which can analyze the large and complex datasets generated by these screens to characterize the phenotypic effects of genetic perturbations at single cell resolution. These tools will be applied to identify core biological pathways underlying blood and neurodegenerative diseases and will be broadly useful to research groups performing these powerful screens.

PI_NAMEs: BLAINE, LOGAN  (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Adopted;Affect;Amyotrophic Lateral Sclerosis;Bayesian Analysis;Bayesian Method;Bayesian Modeling;behavioral study;Benchmarking;Biological;Biological Assay;Biological Process;cell behavior;Cell Line;Cells;Cellular Morphology;Chromatin;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;complex data;Computer Analysis;computerized tools;CRISPR screen;CRISPR/Cas technology;Data;Data Set;Democracy;design;Dimensions;empowerment;Enhancers;Erythroid Progenitor Cells;erythroleukemic cell;explainable machine learning;familial amyotrophic lateral sclerosis;Fetal Hemoglobin;Fibroblasts;Fluorescence Microscopy;gene discovery;Gene Expression;Gene Expression Profile;gene regulatory network;Genes;Genetic;Genetic Induction;Genetic Screening;Genome;Genome engineering;Hematological Disease;Human;Human Cell Line;Image;in situ sequencing;Individual;Inflammatory;insight;Investigation;K-562;laptop;machine learning method;Measures;Methodology;Methods;Modality;Morphology;Mutation;Nervous System Disorder;Neurodegenerative Disorders;Neurons;novel;Optics;Pathway interactions;Performance;Phenotype;Proteins;Regulatory Element;Research;Resolution;RNA;RNA-Binding Protein FUS;Role;screening;Signal Pathway;single cell analysis;single cell sequencing;single-cell RNA sequencing;Statistical Data Interpretation;Subcellular structure;Testing;Therapeutic;therapeutic development;therapeutic target;Time;tool;Transcript;transcriptome;Work

PROJECT_TITLE: Robust and scalable Bayesian analysis tools for single cell CRISPR screens with sequencing- and imaging-based readouts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative This project leverages advances in genomics and genetics to understand molecular mechanisms underlying neurodegenerative diseases like Alzheimer’s disease and unravel how oligodendrocytes are altered in disease. Using multiple layers of genomics data from human and mouse samples, we develop a framework for integrative study of neurodegenerative diseases and find potential regulators of the disease, which are likely to be novel drug targets.

PI_NAMEs: SWARUP, VIVEK  (contact)

PROJECT_TERMS: 3xTg-AD mouse;Affect;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;ATAC-seq;Autopsy;Axon;Behavioral;Binding Proteins;Binding Sites;Bioinformatics;Biology;Brain;Brain Diseases;Brain region;Cell Nucleus;Cell Physiology;cell type;Cells;Central Nervous System;cholesterol biosynthesis;Chromatin;Complex;Data;Data Science;Databases;Dependovirus;differential expression;Disease;Disease Progression;DNA Sequence Alteration;economic cost;Ensure;epigenomics;Experimental Designs;experimental study;functional genomics;Gene Expression;Genes;Genetic;genetic analysis;genetic manipulation;Genetic Transcription;genome-wide;Genomic approach;genomic data;Genomics;Heterogeneity;Human;human data;human old age (65+);Immunohistochemistry;In Situ Hybridization;insight;Maps;Metabolic;Molecular;Molecular Biology;mouse model;Multiomic Data;multiscale data;Mus;Myelin;myelination;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;new therapeutic target;novel;Older Population;Oligodendroglia;overexpression;Pathogenesis;Pathologic;Pathology;Population;Prefrontal Cortex;Prevalence;programs;Proteomics;Regulatory Element;Reporting;Resolution;Risk Factors;risk variant;Role;Sampling;Sex Differences;single molecule;single nucleus RNA-sequencing;Specimen;Sterols;Systems Biology;Temporal Lobe;Tissues;transcription factor;transcriptome sequencing;transcriptomics;Translating;Work

PROJECT_TITLE: Oligodendrocyte heterogeneity in Alzheimer' s disease

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: NARRATIVE  Alzheimer’s Disease (AD) is a devasting degenerative brain disease that is increasing in prevalence and there is no effective treatment. Although very rare forms of the disease are caused by inheriting abnormal genes, most cases have no definitive genetic cause, although many risk-associated genes have been identified. These studies will focus on the role of one risk-associated gene, angiotensin converting enzyme (ACE) and its function in processing abnormal proteins produced in the brain in patients with AD that lead to neuron death and dementia.

PI_NAMEs: TOURTELLOTTE, WARREN G (contact)

PROJECT_TERMS: Abeta clearance;Ablation;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;American;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Animal Model;Automobile Driving;Autophagocytosis;autosomal dominant mutation;Biological;Brain;Brain Diseases;Bypass;Cell Physiology;Cells;Central Nervous System;Cessation of life;Chronic;cognitive function;cytokine;Data;Degenerative Disorder;Dementia;Deposition;Disease;Doxycycline;Early Onset Familial Alzheimer's Disease;effective therapy;Endosomes;engineered stem cells;Engraftment;Experimental Designs;familial Alzheimer disease;Gene Abnormality;Gene Expression;gene interaction;gene network;Genes;Genetic;Homeostasis;Human;human old age (65+);Immune;immune function;Impairment;In Vitro;in vivo;induced pluripotent stem cell;Inflammatory;Investigation;Learning;Life;Mediating;Mediator;Memory impairment;Methods;Microglia;Molecular;mouse model;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;neuron loss;neurotoxic;neurotoxicity;novel;novel therapeutics;overexpression;Pathogenesis;Peptidyl-Dipeptidase A;Phagocytosis;presenilin-1;presenilin-2;Prevalence;Prevention;Production;protein degradation;Proteins;proteostasis;Publishing;response;Risk;Role;Signal Pathway;Synapses;Testing;trafficking;Transgenic Mice;trend

PROJECT_TITLE: Modulating microglial function to restore A-beta proteostasis in Alzheimer's Disease

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG-R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE This project will provide the most comprehensive interrogation of the genetics of aging-related cognitive changes during prodromal, so-called “silent,” periods of AD/ADRD progression. Identifying the genetic risk factors and biological mechanisms underlying progression to clinical AD/ADRD is crucial to developing interventions to prevent, delay, or otherwise mitigate AD/ADRD progression.

PI_NAMEs: TUCKER-DROB, ELLIOT MAX (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Acceleration;Adult;Affect;Age;age difference;age stratification;Aging;aging related;aging related disease;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's Disease Pathway;Alzheimer's disease related dementia;Alzheimer's disease risk;Basic Science;Biological;biological sex;Birth;Brain imaging;cardiovascular health;case control;Categories;Clinical;clinical application;cognitive change;cognitive function;cognitive testing;cohort;Data;Data Analyses;Dementia;dementia risk;design;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;emerging adult;epidemiology study;Equation;Ethics;Event;Exercise;Functional disorder;gene conservation;Genes;Genetic;genetic association;Genetic Polymorphism;Genetic Risk;genetic risk factor;genetic variant;genome wide association study;genome-wide;Genomics;Genotype;Goals;Health and Retirement Study;Health behavior;Impaired cognition;Impairment;improved;indexing;Individual;innovation;Intervention;late life;Longitudinal Studies;Measures;Memory;Methods;Modeling;Molecular;Nerve Degeneration;neural;Neurobiology;neurocognitive disorder;Neurons;neurophysiology;novel;Participant;Persons;Phenotype;physical conditioning;prevent;Prevention;Process;processing speed;psychosocial;rate of aging;Risk;risk sharing;Sampling;Smoking;Societies;Time;Validation;Variant

PROJECT_TITLE: Large-Scale Genomic Analysis of Aging-Related Cognitive Change Prior to Dementia Onset

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ORG_CITY: Los Angeles

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Alzheimer's disease is the most common neurodegenerative disorder in humans. Genomic studies indicate that the response of the immune system can either exacerbate or mitigate the disease. Here, the mode of action of an immune receptor that is central to this response will be elucidated to guide a novel Alzheimer's disease therapy.

PI_NAMEs: ULMER, TOBIAS SEBASTIAN (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: abeta accumulation;Abeta clearance;Adaptive Immune System;Affinity;Alzheimer's Disease;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Amyloid;Amyloid beta-Protein;Behavior;beta amyloid pathology;Binding;Binding Proteins;Biochemical;Biology;CBL gene;Cell Physiology;Cell Surface Receptors;Cellular biology;Central Nervous System;combat;cytotoxic;Development;dimer;Dimerization;Disease;Exhibits;experience;extracellular;Family;Genes;genome wide association study;Genomics;glycosylation;Human;Immersion;Immune response;Immunoglobulin Domain;Immunoglobulins;Immunologic Receptors;Immunomodulators;Individual;Inflammatory;inhibitor;Innate Immune Response;Innate Immune System;insight;interest;Intervention;Isotope Labeling;Length;Ligand Binding;Ligand Binding Domain;Ligands;Link;Macrophage;Membrane;Microglia;Neurodegenerative Disorders;neuroprotection;NMR Spectroscopy;novel;Pathogenesis;Phagocytes;Phagocytosis;pharmacologic;Phenotype;Phospholipids;Point Mutation;Polysaccharides;receptor;Receptor Activation;Receptor Signaling;reconstitution;Research;Resolution;response;sialic acid binding Ig-like lectin;Sialic Acids;Signal Transduction;Site;Structure;System;Testing;Therapeutic;Translating;Transmembrane Domain;transmission process

PROJECT_TITLE: Mechanism of CD33 receptor signaling in Alzheimer disease

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: NARRATIVE The human brain is supplied by a dense array of vessels where each neuron has its supplying capillary. Aging impairs functionally and structurally the cerebromicrovasculature and thus induces consequential neuronal dysfunction and cognitive impairment. Our recent studies using heterochronic blood exchange (HBE) in mice showed that young blood rescues the age-related decline in signaling via the NAD+/SIRT1 axis and reverses circulating IGF-1 deficiency, each of which can result in vascular mitochondrial rejuvenation, attenuation of endothelial oxidative stress, improved endothelial vasodilator function and restoration of endothelial angiogenic processes, improving brain health.

PI_NAMEs: CSISZAR, ANNA ;UNGVARI, ZOLTAN ISTVAN (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Abbreviations;Affect;age acceleration;age related;age related decline;aged;Aging;aging process;anti aging;attenuation;Biological Assay;Biological Availability;Blood;Blood capillaries;Blood Vessels;Brain;brain health;Capillarity;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Clinical Research;Cognitive;cognitive function;cost estimate;Data;density;Endothelial Cells;endothelial dysfunction;Endothelium;Enzymes;Etiology;experimental study;extracellular;Functional impairment;Gene Expression Profile;Goals;healthy aging;Hippocampus;Homeostasis;Human;human old age (65+);human subject;Hyperemia;Impaired cognition;Impairment;improved;Insulin-Like Growth Factor I;Ischemia;Machine Learning;Measurement;Measures;Mediating;Mitochondria;mitochondrial dysfunction;Modeling;Mus;Neuronal Dysfunction;Neurons;neurovascular;neurovascular coupling;nicotinamide phosphoribosyltransferase;nonhuman primate;novel;Nutrient;Oklahoma;old mice;older patient;Oxidative Stress;Oxygen;Parabiosis;Participant;Pathogenesis;pathological aging;Pathway interactions;Patients;Persons;Phenotype;Play;preclinical study;prevent;Prevention;Process;Production;protective effect;Publishing;Reactive Oxygen Species;Rejuvenation;response;restoration;Rodent Model;Role;Series;Serum;Signal Transduction;SIRT1 gene;Testing;transcriptomics;vascular cognitive impairment and dementia;Vascular Endothelium;Vasodilation;Vasodilator Agents;Work

PROJECT_TITLE: Cerebromicrovascular rejuvenation by heterochronic blood exchange


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Brain Disorders;Cerebrovascular;Dementia;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE);Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PATHOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative  Although most studies in Alzheimer disease (AD) so far have focused on amyloid β, interest in Tau is growing because of the discovery of the central role of Tau in neurodegeneration and the difficulties associated with the targeting of amyloid β to develop mechanism-based treatments for AD. The main goals of this project are to elucidate the structural basis and pathological mechanisms implicated in Gerstmann-Sträussler-Sheinker (GSS, F198S) disease and Prion protein cerebral amyloid angiopathy (PrP-CAA, Q160X), in which Tau deposits are composed by 3R+4R Tau, as in AD.

PI_NAMEs: GHETTI, BERNARDINO FRANCESCO;JIANG, WEN ;VIDAL, RUBEN  (contact)

PROJECT_TERMS: abeta accumulation;Address;Age;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;amyloid peptide;Amyloidosis;Binding;Biochemical;Blood Vessels;Brain;brain parenchyma;British;Central Nervous System;Cerebral Amyloid Angiopathy;chronic traumatic encephalopathy;Clinical;Complex;conformer;corticobasal degeneration;Cryoelectron Microscopy;Data;Dementia;Deposition;design;Disease;extracellular;Gene Mutation;Genetic;Genetic Polymorphism;Goals;Hippocampus;Human;hyperphosphorylated tau;In Vitro;in vivo;in vivo evaluation;Indiana;Individual;Inherited;interest;Investigation;Laboratories;Lead;Maps;Mass Spectrum Analysis;Microtubules;Modeling;Molecular;Molecular Biology;Molecular Conformation;multidisciplinary;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;neuropathology;next generation sequencing;novel;novel diagnostics;novel therapeutics;Pathologic;Pathology;Patients;Pattern;Peptides;Phenotype;Pick Disease of the Brain;Positioning Attribute;Post-Translational Protein Processing;Prion Diseases;Protein Isoforms;Proteomics;PrP;PrP amyloid;PrP gene;Role;Senile Plaques;Specificity;Structure;tau aggregation;tau conformation;tau mutation;tau Proteins;tau-1;Universities;Wild Type Mouse;Work

PROJECT_TITLE: Structural analysis of tau associated with parenchymal and vascular prion protein amyloidosis

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Sexually Transmitted Infections

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative This large, population-based study will reveal the relationship between HIV and the natural history of oral human papillomavirus (HPV) infection in an at-risk cohort of males living with HIV. This information will be critical for developing screening algorithms to identify males at high risk of developing HPV-related oropharyngeal cancer (HPV-OPC), who would benefit from preventive treatment or early-stage treatment when outcomes are most favorable. Ultimately, the knowledge gained from this study will translate into strategies to mitigate the risk of HPV-OPC among males living with HIV.

PI_NAMEs: NOWAK, REBECCA G. (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Accounting;Age;Alcohol consumption;Algorithms;antiretroviral therapy;Anus;Biological;Blood specimen;carcinogenicity;Caring;cisgender;Clinic;Clinical;Clinical Data;Clinical Markers;clinical phenotype;cohort;Collaborations;Data;Dental;Dental caries;Detection;Development;Diagnosis;Disease Progression;early detection biomarkers;Early Diagnosis;Early treatment;effective intervention;Enrollment;epidemiology study;Event;Friends;General Population;High Prevalence;high risk;high risk population;HIV;HIV Seronegativity;HPV negative;HPV oropharyngeal cancer;HPV screening;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Incidence;Infection;International;Knowledge;Lesion;Logistic Regressions;Longitudinal cohort study;Low Prevalence;male;Measures;Mediating;microbial;multidisciplinary;Natural History;Nigeria;Nigerian;non-heterosexual;nonbinary;Oral;Oral cavity;Oral Characters;oral HPV infection;oral lesion;oral microbiome;Oral Sex;Outcome;Participant;Patient Self-Report;Patients;penis;Periodontal Diseases;Phenotype;Population Control;Population Study;Populations at Risk;predictive modeling;premalignant;Prevalence;Prevention strategy;Preventive treatment;prospective;Prospective Studies;Questionnaires;Recording of previous events;Request for Applications;Research;Risk;Risk Factors;risk mitigation;risk stratification;Sampling;screening;Sexual and Gender Minorities;Sexual Partners;Smoking;Testing;therapy adherence;Time;transgender;Translating;Treatment outcome;tumor-immune system interactions;unvaccinated;Viral Load result

PROJECT_TITLE: Characterize longitudinal events of oral high-risk human papillomavirus among an at-risk population (CLEAR)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 CC (10)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Digestive Diseases;Microbiome;Neurodegenerative;Neurosciences

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Advanced age is the greatest risk factor for the onset and progression of Alzheimer's disease. We are using the powerful genetics of the fruit fly Drosophila to better understand the biological mechanisms of aging. The long-term goal of this research is to provide novel therapeutic targets to counteract age-related human diseases, including Alzheimer's disease.

PI_NAMEs: WALKER, DAVID W (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: abeta toxicity;Actins;Affect;Age;Age of Onset;age related changes;age-related disease;aged;Aging;aging biomarker;aging brain;aging mechanism;aging population;aging related disease;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;animal old age;Biological;Body System;Brain;Dementia;Development;Disease;Distal;Drosophila genus;dysbiosis;Elderly;F-Actin;functional decline;Functional disorder;Genetic;Goals;gut microbiota;hallmarks of aging;Health;healthspan;healthy aging;Homeostasis;Human;immune system function;improved;Individual;Intervention;intestinal barrier;intestinal homeostasis;Intestines;Knowledge;Learning;life span;Link;Longevity;Mediating;Memory;Memory Loss;Mental disorders;microbial;Microfilaments;Mitochondria;mitochondrial dysfunction;model organism;Monkeys;Mus;Nervous System;Neurodegenerative Disorders;neuroinflammation;Neurons;neurotoxicity;new therapeutic target;novel strategies;novel therapeutic intervention;novel therapeutics;nutrient metabolism;Onset of illness;Organism;Pathogenesis;Pathology;Phenotype;Physiology;Population;proteostasis;proteostasis loss;Research;Risk Factors;Rod;Role;Sleep;Societies;Symptoms;Work

PROJECT_TITLE: Role of Intestinal Homeostasis in Organismal Aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Depression;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Osteoporosis;Prevention;Sleep Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Depression and Alzheimer’s Disease and Related Dementias are among the leading contributors to morbidity, disability, and mortality worldwide. This project will apply novel machine learning techniques to large multi-cohort samples to determine whether multidimensional sleep health predicts cognitive outcomes (change in cognition, incident dementia; Aim 1) and change in depressive symptoms (Aim 2), and examine depressive symptoms as a pathway through which multidimensional sleep health predicts cognitive outcomes. Through our multi-cohort secondary data analysis approach, which offers enhanced generalizability and power and an efficient use of existing resources, our findings will directly inform the design of subsequent prospective studies aimed at developing integrated approaches to treating depression and cognitive decline in older adults, with implications for preventing Alzheimer’s Disease and Related Dementias.

PI_NAMEs: WALLACE, MEREDITH JOANNE LOTZ (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: actigraphy;Adult;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Atherosclerosis;Automobile Driving;Behavioral;Biometry;Characteristics;Clinical;Cognition;Cognitive;cognitive function;cohort;Cohort Studies;Complex;Cost efficiency;Data;Data Analyses;data harmonization;Dementia;Deposition;depressive symptoms;design;Diagnosis;Dimensions;disability;Disease;Drowsiness;Ethics;ethnic diversity;European;explainable machine learning;flexibility;Functional disorder;Funding;Future;Guide prevention;Health;Health behavior;high dimensionality;human old age (65+);Impaired cognition;improved;indexing;Individual;Internet;Intervention;Intervention Studies;Investigation;Machine Learning;machine learning method;Major Depressive Disorder;Measures;Mediation;Medical Records;Memory;men;Mental Depression;Methodology;Methods;Minority;modifiable risk;Morbidity - disease rate;mortality;Multi-Ethnic Study of Atherosclerosis;novel;older adult;osteoporosis with pathological fracture;Outcome;Outcome Measure;Participant;Pathway interactions;Patient Self-Report;Persons;physical conditioning;prevent;Prospective Studies;Public Health;Race;racial diversity;random forest;research study;Resources;Rest;Risk Factors;Sampling;Sampling Studies;satisfaction;secondary analysis;sex;Sex Differences;Sleep;Sleep Disorders;sleep health;sleep-focused interventions;sociodemographic factors;Statistical Methods;success;Techniques;Testing;Time;Visit;Work

PROJECT_TITLE: Sleep Health Profiles Predicting Impaired Cognition and Depressive Symptoms in Older Adults: Extending Novel Statistical Methods in Multi-Cohort Applications

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Immunization;Immunotherapy

ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

PHR: Narrative This application requests NIH support for a conference that brings together an interdisciplinary and diverse group of scientists who are focused on solving important problems in immunobiology. This meeting will highlight the latest technological advances in immune cell research, with a focus on understanding immune receptor function and the complexities of immunotherapy. This research is very important to human health because it helps to drive new therapeutic strategies for harnessing the power of immune cells in targeting diseases, including autoimmunity, infectious disease and cancer.

PI_NAMEs: LIDKE, DIANE  (contact)

PROGRAM_OFFICER_NAME: BARTELS, ADELINA EWURA-ABENA

PROJECT_TERMS: Address;antibody engineering;Autoimmune Diseases;Autoimmunity;Award;Basic Science;bench to bedside;Biology;built environment;career;career networking;Cell Physiology;Cells;Clinic;Collaborations;collaborative environment;Collection;Communicable Diseases;Communities;community engagement;Complex;Computer Models;Disease;Educational workshop;efficacious treatment;Ensure;Environment;Equity;Exposure to;Fertilization;fighting;Financial Support;Fostering;Funding;Goals;Health;Human;Image;Immune;Immune system;Immune System Diseases;Immunity;Immunobiology;Immunologic Receptors;Immunologic Stimulation;Immunotherapy;Infection;Inflammatory;interdisciplinary collaboration;International;Knowledge;Ligands;Malignant Neoplasms;meetings;Membrane;Minnesota;novel therapeutic intervention;Organ;Organizational Objectives;Participant;Pathology;Patients;Persons;Physiology;Play;posters;programs;receptor;receptor function;Request for Applications;Research;Research Personnel;Role;Running;Science;Scientist;Secure;Series;Signal Transduction;Site;Structure;summer research;symposium;Systems Biology;Technology;Therapeutic;therapeutic target;Tissues;translational applications;Translations;Travel;Underrepresented Populations;United States National Institutes of Health

PROJECT_TITLE: Immunoreceptors and Immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LK-D (J1)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Bioengineering

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: PROJECT NARRATIVE The 2024 Gordon Research Conference on Musculoskeletal (MSK) Biology & Bioengineering is focused on facilitating the development and implementation of collaborative approaches to improve MSK health and is themed “Multidisciplinary Approaches to Tackling Musculoskeletal Problems Across the Lifespan”. A companion Gordon Research Seminar, themed “Integrating Diverse and Multidisciplinary Approaches to Enhance Musculoskeletal Health” seeks to develop and foster the next generation of MSK investigators through a combination of scientific and mentoring sessions. Collectively, these meetings, which prioritize discussion time, information interactions, and mentorship will advance the pace of discovery related to musculoskeletal disease.

PI_NAMEs: LOISELLE, ALAYNA  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Academy;Address;Aging;Area;Basic Science;Biological;Biology;Biomedical Engineering;career;Clinical;Collaborations;collaborative approach;Communities;Companions;Data;design;Development;Disabled Persons;Disease;Engineering;Ensure;Environment;Equity;Fostering;Funding;Future;Goals;graduate student;Health;health equity;Helping to End Addiction Long-term;Hour;improved;Individual;innovation;interdisciplinary approach;Laboratories;Leadership;Leisures;life span;Location;meetings;Mentors;Mentorship;Minority;multidisciplinary;Musculoskeletal;Musculoskeletal Diseases;Musculoskeletal System;Nature;next generation;Oral;Orthopedics;Pain;Pain Research;Participant;Postdoctoral Fellow;posters;programs;Recreation;Relaxation;Request for Proposals;Research;Research Personnel;restoration;Schedule;Science;Scientific Advances and Accomplishments;Scientist;social;symposium;Time;Tissues;United States National Institutes of Health;Voice;Woman;Work

PROJECT_TITLE: 2024 Musculoskeletal Biology and Bioengineering Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Heart Disease

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The proposed studies will identify novel small molecules using patented prototype P7C3 based discovery pipeline for Heart failure treatment. The new P7C3 based novel small molecule discovery and synthesis will allow to optimize the efficacy, cell permeability and EC50 for higher therapeutic potential. Overall, the project will generate high impact translational data with discovery of P7C3 (Nampt activator) based small molecules for attenuating cardiovascular diseases and new product development.

PI_NAMEs: TIPPARAJU, SRINIVAS M. (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Address;Affinity;aging population;Anabolism;Area;Arrhythmia;Attenuated;Award;Biological Models;Carbazoles;Cardiac;Cardiac Myocytes;Cardiomyopathies;cardioprotection;Cardiovascular Diseases;Cell Physiology;Cells;commercialization;cost;Coupled;Creatinine;Data;design;Development;Diabetes Mellitus;Disease Management;Docking;Dose;Drug Design;drug development;drug discovery;drug testing;Echocardiography;efficacy study;Electrocardiogram;Energy Metabolism;enzyme activity;Enzymes;Equilibrium;Ethanol;Evaluation;experimental study;Fibrosis;Florida;Generations;Heart;Heart Abnormalities;Heart failure;heart function;Heart Hypertrophy;Heart Injuries;heart rhythm;Homeostasis;In Vitro;in vitro Assay;in vitro Model;in vivo;in vivo evaluation;Incubators;Infusion procedures;Injury;innovation;interest;Ischemia;Isoproterenol;Knockout Mice;Lactate Dehydrogenase;Lead;Legal patent;Link;Measures;Mediating;Metabolic;Metabolic syndrome;mitochondrial dysfunction;Modeling;Morbidity - disease rate;mortality;Mus;Myocardial Infarction;NADH;Natural regeneration;new product development;Nicotinamide adenine dinucleotide;nicotinamide phosphoribosyltransferase;novel;novel therapeutics;Nucleotides;Obesity;Osmosis;Outcome;Oxidation-Reduction;Pathologic;Pathway interactions;Patients;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase;Phosphotransferases;Play;pre-clinical assessment;Pre-Clinical Model;Predisposition;product development;Production;prototype;Public Health;Pump;pyridine nucleotide;Recovery;repaired;Research;Role;Sampling;screening;Serum;small molecule;small molecule therapeutics;Sodium Lactate;Solubility;Specificity;Stroke;Structure-Activity Relationship;Sudden Death;symptom management;Symptoms;System;Testing;Therapeutic;therapeutic candidate;therapeutic development;three dimensional structure;Three-dimensional analysis;Time;Tissues;Toxic effect;translational impact;translational potential;Treatment Failure;treatment strategy;Troponin I;Universities

PROJECT_TITLE: P7C3 based small molecule for Heart failure treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-F (J1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

PHR: The underlying causes and treatment of dementias observed with advanced age remain poorly understood and are a major unmet need for the aging population. This proposal explores a novel protein that prevents mild cognitive decline normally associated with natural aging, determining whether it prevents or delays severe neurodegenerative conditions observed with aging and Alzheimer’s disease (AD) and AD-related diseases.

PI_NAMEs: BUTLER, ANDREW ALISTAIR (contact);FARR, SUSAN A

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: abeta accumulation;Acceleration;Address;Adult;Affect;Age;age acceleration;Age Months;age related;aged;Aging;aging population;aging related;Agonist;Alleles;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Amyloid beta-Protein;Behavioral;Biochemical;Birth Rate;Brain;Brain Pathology;brain tissue;Cessation of life;Clinical Data;Clinical Trials;Cognition;cognitive change;Cognitive deficits;cognitive function;Communities;Data;Dementia;dementia burden;dementia risk;Deterioration;Diagnosis;Disease;disorder risk;Dose;Elderly;Encephalitis;Episodic memory;Exhibits;experimental study;Family member;Functional disorder;Future;gene network;GLP-I receptor;Health;Heterozygote;high risk;Homeostasis;Human;Impaired cognition;improved;Inflammation;Insulin Resistance;insulin sensitivity;insulin signaling;Investigation;Knock-out;Knockout Mice;Knowledge;Lead;Learning;Life Expectancy;life span;Link;male;Measures;Memory;Memory impairment;Memory Loss;memory recognition;Metabolic;mild cognitive impairment;Mitochondria;Modeling;mouse model;mRNA Expression;Mus;Nerve Degeneration;Nervous System;neurochemistry;Neurodegenerative Disorders;neuron loss;Neurons;neuropathology;Neuropeptides;neuroprotection;Neuroprotective Agents;Non-Insulin-Dependent Diabetes Mellitus;normal aging;novel;Onset of illness;Oxidative Stress;Patients;Peptides;Peripheral;Persons;Phenotype;polypeptide;Population;Population Sizes;pre-clinical;preclinical study;Predisposition;Prevalence;prevent;Process;Proteins;Publishing;Reporting;Research;response;Risk Factors;Rodent;Rodent Model;Role;side effect;Signal Transduction;social;Societies;Source;speech processing;Structure;success;Synapses;synaptic function;tau Proteins;Testing;Therapeutic;therapy development;Transcript;Vascular Diseases;Visual

PROJECT_TITLE: An investigation of the response of preclinical mouse models of dementia to adropin therapy

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Urologic Diseases;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Paradigm-shifting research has revealed that urethral failure, long thought to be unimportant, plays a major role in incontinence. Studies of the role of advancing age and disease in causing urethral failure and incontinence are blocked by the use of obsolete, artifact-prone testing equipment and outdated conceptual models. By providing the next generation of urethral testing equipment and computer modeling that capitalizes on advances in sensor and imaging technology, we will provide the needed armamentarium to conduct studies of urethral failure mechanisms that can lead to novel therapeutic targets and treatable disease processes.

PI_NAMEs: ASHTON-MILLER, JAMES ANTHONY;DELANCEY, JOHN O.L. (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: 3-Dimensional;Accelerometer;Adult;advanced disease;Affect;Age;age effect;American;Anatomy;Assessment tool;Atlases;Bladder;Blood Vessels;Catheters;Cells;Childbirth;Communities;Complex;Computer Models;cost;Data;design;Development;Diabetes Mellitus;Disease;Distress;elastography;Elderly;Elements;Equipment;Event;experience;Failure;Female urethral structure;Genetic;Image;Imaging technology;In Vitro;in vivo;Incontinence;Individual;Injury;intravesical;kinematics;Maps;Measurement;Measures;mechanical properties;Modeling;Morphologic artifacts;Muscle;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;next generation;novel;Organ;Physics;Physiological;Play;pressure;Probability;Process;Race;Research;Research Personnel;Resolution;Resources;Role;Scanning;Science;sensor;sensor technology;Sensory;Site;social;Sphincter;Stigmatization;Stress;Stress Urinary Incontinence;stressor;Structure;Structure-Activity Relationship;System;Technology;Testing;therapeutic target;Time;tool;Ultrasonography;ultrasound;United States National Institutes of Health;Urethra;Urethral sphincter;Urge Incontinence;urinary;Urinary Incontinence;wearable device;Woman;Work

PROJECT_TITLE: Development of 21st Century Concepts and Tools for Quantifying Urethral Failure Mechanisms that Cause Urinary Incontinence


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE: Degeneration of the retinal pigment epithelium (RPE) underlies age-related macular degeneration (AMD), the leading cause of irreversible vision loss in the developed world. Avenues to improve RPE function in the dry form of AMD are desperately needed, as the disease currently has no FDA-approved treatments. Here, we explore the role of a lipid storage organelle, termed a lipid droplet, in maintaining the RPE’s health and function, with implications for developing novel therapeutics for dry AMD.

PI_NAMEs: MILLER, JASON MATTHEW-LEWIS (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Age related macular degeneration;Apical;Award;Basic Science;Biochemical;Bioenergetics;Biology;Blindness;career;career development;Cell Nucleus;Cell Respiration;cell type;Cells;Characteristics;cholesterol analog;Choroid;choroidal circulation;Consumption;Data;Deposition;Development Plans;Disease;Drusen;Dryness;Endoplasmic Reticulum;Ensure;Enzymes;Equilibrium;experience;extracellular;FDA approved;flexibility;Foundations;Glucose;Goals;Health;Homeostasis;Human;Impairment;improved;induced pluripotent stem cell;Ingestion;Label;Lipase;lipid metabolism;Lipid Mobilization;Lipid Peroxidation;lipid transport;lipidomics;Lipids;Lipoproteins;Lysosomes;Mass Spectrum Analysis;Mechanics;Mediating;Mentors;Mentorship;Metabolic;Metabolism;Methods;Michigan;Microscopy;Mitochondria;mitochondrial metabolism;Modeling;Monitor;Morbidity - disease rate;Natural regeneration;Nonesterified Fatty Acids;Nonexudative age-related macular degeneration;novel;novel therapeutics;Organelles;oxidation;oxidative damage;particle;Pathologic;Pathway interactions;Phagocytosis;pharmacologic;Photoreceptors;Physiological;Physiology;Play;prevent;Principal Investigator;Process;programs;Radiolabeled;Reporter;Research;Research Personnel;Resolution;response;Retina;Retinal Degeneration;Retinal Diseases;Role;Small Interfering RNA;small molecule;Structure of retinal pigment epithelium;Testing;Tissues;Tracer;Universities;uptake;visual cycle

PROJECT_TITLE: Lipid Trafficking and Metabolism in the Retinal Pigment Epithelium


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative  We previously demonstrated that pancreatic tumors depend on the amino acid cysteine in order to prevent cell death through a process called ferroptosis. Here we propose to improve the anti-cancer effects of cysteine depletion by targeting complementary aspects of tumor metabolism and immunity. These proposed studies will also further illuminate the mechanisms of cysteine depletion and ferroptosis in pancreatic cancer.

PI_NAMEs: OLIVE, KENNETH P. (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: 4'-phosphopantetheine;Acute;Alleles;Amino Acids;anti-cancer;Antioxidants;antiporter;Autophagocytosis;Basic Science;Biochemical;Cancer Etiology;Cell Death;Cell Line;Cells;Cellular Membrane;Cessation of life;Chemistry;clinical translation;Coenzyme A;comparative efficacy;Cyst;Cysteine;Cystine;Cytotoxic Chemotherapy;Data;detoxication;Detoxification Process;Diet;dietary;Disulfides;Drug Metabolic Detoxication;Electrons;Engineering;Enzymes;extracellular;FDA approved;Ferritin;Generations;Genetic;Genetic Engineering;Genetically Engineered Mouse;Glutamates;Goals;Grant;Human;Hypoxia;Immunotherapy;improved;in vivo;inhibitor;Intercellular Fluid;Interruption;Iron;Knockout Mice;KRAS2 gene;Learning;Lipids;macromolecule;Malignant Epithelial Cell;Malignant neoplasm of pancreas;Malignant Neoplasms;Mammalian Cell;Mediating;MEK inhibition;MEKs;Membrane;Membrane Lipids;Metabolism;Methods;Modeling;Molecular Biology;mortality;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Necrosis;Normal Cell;novel;Oncoproteins;Osmosis;Oxidation-Reduction;oxidative damage;Oxidative Stress;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathway interactions;Patients;peroxidation;Pharmaceutical Preparations;pharmacologic;Phenocopy;Phenotype;Physiological;Polyunsaturated Fatty Acids;preclinical efficacy;prevent;Process;Production;programs;Property;Proteins;Reaction;Reactive Oxygen Species;recombinase;Regimen;Resistance;response;Role;Rupture;Sampling;Science;semi essential amino acid;Side;Source;Stable Isotope Labeling;Sulfhydryl Compounds;System;Systems Biology;targeted treatment;Techniques;Testing;therapeutic target;therapeutically effective;Tissues;TP53 gene;translational approach;tumor;Tumor Immunity;tumor metabolism;tumor microenvironment;United States;uptake;Water;Work

PROJECT_TITLE: Targeting cysteine import to induce ferroptotic cell death in pancreatic cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Mental Health;Pain Research;Social Determinants of Health;Telehealth

ORG_CITY: LEXINGTON

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Chronic masticatory muscle pain disorders (MMPD) affect between 5-12% of the adult population and are the most common cause of chronic non-odontogenic orofacial pain. Combining standard dental care with brief telehealth psychological interventions offers hope for reducing negative pain outcomes and improving quality of life in this population, but few such interventions exist. The proposed submission will generate data to support a future full-scale Phase II efficacy trial of a brief telehealth psychological intervention for MMPD, potentially leading to an efficacious, widely implementable, and disseminatable treatment option for patients with chronic MMPD.

PI_NAMEs: BOGGERO, IAN ANDRES (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: active control;Address;Adult;Affect;Age;anxiety symptoms;Awareness;biopsychosocial;biopsychosocial factor;career;career development;Caring;Chronic;Chronic low back pain;chronic pain;chronic painful condition;Clinical;Clinical Research;collaborative environment;comorbidity;Continuity of Patient Care;coping;cost;COVID-19 pandemic;Data;Dental;Dental Care;depressive symptoms;design;Disease;Educational process of instructing;efficacy testing;efficacy trial;Eligibility Determination;Exercise;Fatigue;Female;Financial Hardship;Future;Goals;Habits;improved;Individual;Informal Social Control;Intervention;intervention effect;Kentucky;Knowledge;Leadership;Literature;Loneliness;Manuals;Masticatory muscles;Mediating;Mediation;Mediator;Medical;Mental Health;Mentors;multidisciplinary;Muscle relaxation phase;Musculoskeletal Pain;Myalgia;Orofacial Pain;Outcome;Pain;pain catastrophizing;Pain Disorder;Pain intensity;Pain interference;Pain management;pain outcome;pain reduction;Participant;Patients;Persistent pain;Persons;Phase;Population;post intervention;Prognosis;psychologic;Public Health;Publishing;Quality of life;Randomized;Readiness;recruit;Relaxation;Reporting;Research;research and development;Research Personnel;research study;retention rate;satisfaction;Self Efficacy;skills;sleep quality;social;Social support;Standardization;Stress;Symptoms;telehealth;Testing;Training;treatment effect;Universities;women patients

PROJECT_TITLE: Initial Evidence for a Brief Psychological Telehealth Intervention for Patients with Chronic Masticatory Muscle Pain


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Opioids;Pain Research;Sleep Research;Substance Misuse

PHR: PROJECT NARRATIVE This mechanistic trial will provide novel information about the contribution of sleep to chronic pain and opioid use. Demonstration that a brief behavioral sleep intervention can facilitate tapered withdrawal from opioid medication and protect against relapse through improvements in sleep, arousal, abnormal brain activation, and pain has important implications for the millions of individuals living with chronic pain, their families, communities, and healthcare.

PI_NAMEs: MCCRAE, CHRISTINA S (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: 18 year old;Adult;Age;Arousal;Arrhythmia;Back;behavioral sleep intervention;blood oxygen level dependent;Brain;brain abnormalities;central sensitization;Cessation of life;Chronic;Chronic Insomnia;chronic pain;chronic widespread pain;Cognitive;Cognitive Therapy;Community Healthcare;comorbidity;craving;Data;Development;Education;Ethnic Origin;Evidence based intervention;Exhibits;experience;Family;follow-up;Healthcare;heart rate variability;Hygiene;improved;improvement on sleep;Individual;Inferior frontal gyrus;Insula of Reil;Intervention;Lead;Lentiform nucleus structure;Long-Term Effects;Mediator;Modeling;Musculoskeletal Pain;Neoadjuvant Therapy;novel;Opioid;Opioid Analgesics;opioid tapering;opioid therapy;opioid use;opioid user;opioid withdrawal;Outcome;Overdose;Pain;Pain management;pain processing;pain reduction;Pain Research;Patients;poor sleep;post intervention;prescription opioid;Protocols documentation;Public Health;Race;Randomized;Relapse;Research;Research Priority;response;Severities;sex;Sleep;Sleeplessness;Stimulus;Stress;Stress Tests;Testing;theories;timeline;trial design;Urine;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Improving Sleep and Reducing Opioid Use in Individuals with Chronic Pain

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ED_INST_TYPE: OVERALL MEDICAL

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Dissecting and targeting a novel vulnerability in Rb1 and p53 doubly deficient prostate cancer Projective Narrative (Relevance) Rb1 and P53 Deficiency (RPD) significantly correlates with poor prognosis in prostate cancer patients, and it has been documented that RPD promotes prostate cancer progression using cells/xenografts/genetic mouse models. However, RPD mechanisms are far from well understood, which has hindered the development of effective treatments. Our proposed study will define GRK3 kinase as a novel vulnerability in RPD prostate cancer, dissect its mechanisms of action and examine the effectiveness of targeting it with first-in-class inhibitors to thwart RPD tumors, which will not only shed light on critical molecular events contributing to the aggressiveness of RPD tumors, but also facilitate the development of novel therapeutics.

PI_NAMEs: LI, WENLIANG  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Ablation;ADRBK1 gene;advanced prostate cancer;Affect;Alleles;American;Automobile Driving;Biology;cancer cell;Cancer Etiology;Cancer Patient;cancer subtypes;cancer type;Cell Line;Cell model;Cells;Cessation of life;Data;Development;effective therapy;effectiveness evaluation;Enhancers;Epigenetic Process;Event;experience;experimental study;fitness;G protein coupled receptor kinase;G-Protein-Coupled Receptors;gene function;gene repression;Genes;Genetic;genetic signature;Genetically Engineered Mouse;Goals;Growth;Homologous Gene;Human;in vivo;inhibitor;insight;kinase inhibitor;Knock-out;Knockout Mice;Knowledge;Libraries;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Mediator;men;Modeling;Molecular;mortality;mouse model;Mutation;Neoplasm Metastasis;neoplastic cell;Nonmetastatic;novel;novel therapeutics;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;Physiological;Prognosis;Property;Prostate;prostate cancer cell;prostate cancer progression;Prostatic Neoplasms;Role;Sampling;screening;Signal Transduction;small hairpin RNA;Specificity;Testing;therapeutically effective;tool;TP53 gene;transcriptome sequencing;transgenic adenocarcinoma of mouse prostate;tumor;tumor growth;tumor progression;Tumor Suppressor Proteins;tumor xenograft;tumorigenesis;Validation;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Dissecting and targeting a novel vulnerability in aggressive Rb1 and p53 doubly deficient prostate cancer

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Data Science;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Patient Safety;Precision Medicine;Prevention;Substance Misuse

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: PROJECT NARRATIVE Clinicians who treat patients with OUD collect standardized clinical data such as urine toxicology and self- report of use of substances, as well as medication dosing and clinic treatment engagement. Nevertheless, it is currently not possible to predict, in real time, what the risk is for a patient to relapse in the next week or month. This project aims to apply well developed contemporary statistical and machine learning methodologies to build such a relapse risk score, which would be of benefit to both clinicians and researchers.

PI_NAMEs: BALISE, RAYMOND ;LUO, SEAN XIAO (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: adaptive intervention;addiction;Address;Administrator;Alcohols;algorithmic bias;Algorithms;autoencoder;automated analysis;Back;Behavior;Behavioral;behavioral outcome;Big Data Methods;care delivery;Clinic;Clinical;clinical application;Clinical Data;clinical decision support;clinical decision-making;Clinical Trials;Clinical Trials Network;Complex;computer framework;Computer software;Conduct Clinical Trials;Data;data harmonization;Data Science;Data Set;Data Sources;data standards;data streams;data structure;Development;dimension reduction;Dimensions;disease model;disorder risk;Dose;Drug abuse;Drug Screening;Drug usage;Enrollment;Evaluation;Foundations;Frequencies;Future;generative adversarial network;Goals;high dimensionality;improved;Individual;individualized medicine;interest;Intervention;Intuition;Learning;learning strategy;Length;Linear Models;longitudinal dataset;machine learning classification;machine learning method;Measures;Methodology;Methods;Modeling;Nicotine;Online Systems;opioid use disorder;Outcome;Outpatients;Participant;Patient Self-Report;Patients;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Play;polysubstance use;Pragmatic clinical trial;predictive modeling;Principal Component Analysis;Procedures;prototype;Questionnaires;Records;Relapse;relapse risk;Reporting;Research;Research Personnel;Risk;Risk Assessment;Risk Estimate;Role;Sampling;Scoring Method;Series;Shapes;Site;Standardization;statistical and machine learning;Stream;Substance of Abuse;substance use;Substance Use Disorder;supervised learning;Surveys;System;Testing;Time;timeline;Toxicology;Urine;usability;user friendly software;Validation;Visualization;web portal;Work

PROJECT_TITLE: Real time relapse risk scoring for Opioid Use Disorder (OUD) from clinical trial datasets

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_DEPT: PEDIATRICS

PHR: Narrative There is a critical need for patient-focused measures to assist in the development of therapies for rare diseases where safe and effective approved therapies are lacking. In this proposed 5-year, multi-phase project, the team aims to develop and establish a publically available patient-focused clinical outcomes assessment core set of measures for nephrotic syndrome patients with fluid overload.

PI_NAMEs: PEIPERT, JOHN DEVIN;SALMON, ELOISE  (contact)

PROGRAM_OFFICER_NAME: BENT, ROBYN S

PROJECT_TITLE: Preparing a clinical outcomes assessment set for nephrotic syndrome [Prepare-NS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Sleep Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE More than 5 million patients are admitted to the intensive care unit every year in the United States; most of these patients experience profound sleep and circadian disruption. Promotion of circadian alignment (i.e., alignment of the body's clocks) would make it possible to strategically schedule behaviors such as sleep and eating at normal body clock times, which is predicted to improve sleep quality and metabolic function. This project will test the ability of a sleep chronobundle (i.e., sleep promotion and circadian treatment bundle) to normalize circadian alignment and subsequently test if this realignment also improves sleep and metabolism.

PI_NAMEs: KNAUERT, MELISSA P (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: 6-sulfatoxymelatonin;Acute;Address;adverse outcome;Architecture;Area Under Curve;Behavior;Biological;Biological Clocks;Body System;Cardiovascular system;Caring;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clinical;Clinical Trials;Cognitive;cognitive system;Coma;Continuous Glucose Monitor;Critical Illness;Cues;Delirium;Eating;Eating Behavior;Evidence based treatment;experience;feeding;Functional disorder;functional improvement;Glucose;glucose metabolism;glucose tolerance;Goals;Guidelines;high risk;Hospitals;Hour;Immune system;Immune System Diseases;improved;improvement on sleep;insight;Intensive Care Units;Investigation;Light;Measures;Mediating;Medical;Metabolic;Metabolic dysfunction;Metabolism;mortality;multi-component intervention;multidisciplinary;muscular system;Noise;Outcome;Patient Admission;patient oriented;Patients;Physiological;Polysomnography;portability;Process;process improvement;Randomized;Randomized, Controlled Trials;Recommendation;Research;respiratory;Respiratory System;Sampling;Schedule;segregation;Skeletal Muscle;Skeletal system;Sleep;sleep behavior;Sleep disturbances;sleep quality;standard measure;success;Testing;Time;Translations;Treatment Efficacy;United States;United States National Institutes of Health;Urine;Ventilator;Work

PROJECT_TITLE: Reestablishing Sleep and Circadian Alignment in Medically Critically Ill Patients via a Mechanistic Randomized Controlled Trial of an ICU Sleep Chronobundle (ReAlign-ICU)


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE

PHR: Results of the proposed experiments could refine strabismus diagnosis and intervention by suggesting that there is diagnostic value in characterizing separately each eye’s rotation dynamics. Furthermore, because the component mechanisms in our framework likely have different neural loci, their malfunction should manifest as distinct symptoms. Moreover, those different neural loci could vary in plasticity potential, and hence could respond differently to therapy, knowledge of which could improve intervention strategies for ocular misalignment disorders.

PI_NAMEs: HEINEN, STEPHEN J (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TITLE: Cortical and Brainstem Contributions to Binocular Eye Movements

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: MERCED

ORG_NAME: UNIVERSITY OF CALIFORNIA, MERCED

PHR: Project Narrative This study of the impact of immigrant policy on the mental health and health care access of foreign- and US-born rural Latinos will produce new data and knowledge on the social determinants of Latino health across diverse rural communities. It will investigate variations in health care access and health status and the influence of county policy contexts, social climates, and Latinos’ own policy encounters on these outcomes. The study will inform policies and interventions aimed at promoting mental health and increasing access to health care and safety net services for Latinos in rural regions.

PI_NAMEs: YOUNG, MARIA-ELENA DE TRINIDAD (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: access disparities;Address;Affect;Arizona;Attitude;California;Categories;Charge;community-level factor;County;Cross-Sectional Studies;Data;Data Set;Enrollment;Environment;Exclusion;experience;Goals;Health;health care availability;health disparity populations;Health Policy;Health Priorities;Health Services Accessibility;Health Status;Immigrant;Immigration;improved;Individual;innovation;Institution;Intervention;Investigation;Knowledge;Latino;Latino Population;Law Enforcement;Measures;Mediating;Mediation;Medicaid;Mental Depression;Mental Health;Mental health promotion;Modeling;National Institute on Minority Health and Health Disparities;Outcome;Policies;Policy Making;Population;population based;Population Study;primary care provider;Public Policy;Public Sector;Research;Resources;Respondent;Rights;Rural;rural area;Rural Community;rural counties;Rural Health;rural setting;safety net;Sampling;Services;Shapes;social culture;social determinants;Social Environment;social factors;social health determinants;Social Perception;Social Work;structural determinants;Surveys;Testing;Urban Community;Urban Health;Variant

PROJECT_TITLE: The Impact of Multiple Levels of Immigrant Policy on Rural Latino Mental Health and Health Care Access

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE SPTBN1 variants cause a global developmental delay syndrome of complex presentation. However, the neuron types that are most vulnerable to deficits in βII-spectrin (encoded by SPTBN1) are unknown. We will determine how βII-spectrin contributes to the organization of excitable axonal domains in cerebellar granule cells.

PI_NAMEs: EDWARDS, REGINALD JAMES (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: ANK2 gene;ANK3 gene;Ankyrins;Attention deficit hyperactivity disorder;Attentional deficit;autism spectrum disorder;Axon;Axonal Transport;Binding;Biochemical;Biological Assay;Brain;Cell Adhesion Molecules;Cerebellar Diseases;Cerebellum;Child;cognitive function;Colon;comorbidity;Complex;Cytoskeleton;Data Analyses;Dendrites;design;Development;Developmental Delay Disorders;Disease;Early Diagnosis;Electrophysiology (science);Epilepsy;Etiology;F-Actin;Fiber;Frequencies;Genetic;global developmental delay;Glutamates;granule cell;Hippocampus;Hyperactivity;Image Analysis;Individual;insight;Intellectual functioning disability;Ion Channel;Lead;live cell imaging;Macromolecular Complexes;Membrane;Membrane Lipids;Membrane Proteins;Membrane Transport Proteins;Microscopy;Molecular;Morphology;Motor;multiple omics;Mus;mutant;Neurodevelopmental Disorder;Neurologic;Neurologic Symptoms;neuron component;neuronal excitability;Neurons;neurotransmission;novel;Organelles;Output;Patients;Play;Preparation;Proteins;Reporting;Research Project Grants;Resolution;Role;Sampling;Scientist;SCN2A protein;Seizures;Signal Transduction;Social Functioning;Sodium Channel;Spectrin;Structure;superresolution microscopy;Synapses;Synaptic Transmission;Synaptic Vesicles;Syndrome;Techniques;Therapeutic Intervention;trafficking;Training;training opportunity;Variant;Vesicle;vesicle transport;vesicular release;voltage

PROJECT_TITLE: Molecular mechanisms of spectrin-dependent axonal organization and function in cerebellar granule cells