NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE  This project proposes to identify a key molecular regulator of mitochondrial lipid oxidation in the retinal pigment epithelium. Since mitochondrial dysfunction is a crucial pathogenic factor in age-related macular degeneration (AMD), the proposed studies will enhance our understanding of this blinding disorder. The information generated from this project has the potential to lead to oral drug treatment for AMD.

PI_NAMEs: MA, JIAN-XING  (contact);TAKAHASHI, YUSUKE

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: 3-nitrotyrosine;Ablation;Acceleration;Adherence;Age;age related;Age related macular degeneration;Age related pathologies;Agonist;Animal Model;ATP-Binding Cassette Transporters;bevacizumab;Binding Proteins;Bruch's basal membrane structure;Carnitine Palmitoyltransferase I;Cell Size;Cells;Cellular Morphology;Cholesterol;Clinical;conditional knockout;Cryoultramicrotomy;Deposition;Diet;Disease;DNA copy number;driving force;drug repurposing;Drusen;Dyslipidemias;effective therapy;Energy-Generating Resources;Enzymes;epithelial injury;Event;Eye;Fatty acid glycerol esters;fatty acid oxidation;fatty acid-binding proteins;Fenofibrate;Functional disorder;Fundus;Genes;Genetic;Genotype;Genus Hippocampus;Glucose;Glycolysis;Histology;Histopathology;Homeostasis;Human;Impairment;Infiltration;Inflammation;Inflammatory;Ingestion;Injections;Knock-out;Knockout Mice;Ligands;Lipid Binding;lipid metabolism;lipid transport;Lipids;LoxP-flanked allele;Macrophage;Measures;Mediating;Metabolic stress;Microglia;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Molecular;mouse model;Mus;neuronal survival;new therapeutic target;Nonexudative age-related macular degeneration;Nuclear Receptors;Optical Coherence Tomography;Oral;overexpression;oxidation;oxidative damage;Oxidative Stress;Oxidative Stress Induction;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;PF4 Gene;Phagocytosis;Pharmacotherapy;Phenotype;Photoreceptors;Play;PPAR alpha;Production;Proteins;Proteomics;Regulation;Retina;retinal damage;Retinal Degeneration;Retinol dehydrogenase;Role;sodium iodate;Structure;Structure of retinal pigment epithelium;Therapeutic;Thick;Tissues;transcription factor;Transgenic Mice;Tuberous Sclerosis;Virulence Factors

PROJECT_TITLE: Dysregulation of PPARα in RPE degeneration


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Genetics;Neurosciences;Organ Transplantation;Pain Research;Transplantation

ORG_CITY: RICHARDSON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PI_NAMEs: SHIERS, STEPHANIE  (contact)

PROJECT_TERMS: arthropathies;Autopsy;Award;Biological Assay;Chest;Chronic disabling pain;chronic pain;Collaborations;Country;Data Set;Data Sources;Development;Dissociation;experience;Funding;Goals;Hospitals;Human;human tissue;Institutional Review Boards;Intervention Studies;Knowledge;Laboratories;Low Back Pain;Lumbar nerve;Maps;Methods;Molecular;Molecular Profiling;Nervous System;Neurons;Nociceptors;Nodose Ganglion;Operative Surgical Procedures;Organ Donations;Organ Donor;Organ Transplantation;Pain;pain patient;Pain Research;Patients;Peripheral Nerves;Persistent pain;Phenotype;Physicians;Price;Procedures;Proliferating;Protocols documentation;Publications;Quality Control;Recording of previous events;Recovery;Research;Research Design;Resected;Resources;RNA;Sampling;Site;Slice;Spinal Cord;Spinal Ganglia;Technology;Therapeutic;timeline;tissue processing;Tissue Procurements;tissue resource;Tissues;transcriptome;transcriptomics;Transplantation;United States;United States National Institutes of Health;University of Texas M D Anderson Cancer Center;Work

PROJECT_TITLE: Human Tissue Procurement and Processing Core


ADMINISTERING_IC: CA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: PROJECT NARRATIVE - OVERALL Glioblastoma is a deadly primary brain tumor, and there has been almost no progress in developing effective therapies for this disease over the past 2 decades. The MIT/DFCI Center for Systems Biology of Glioblastoma will use sophisticated techniques to better understand how growth of these tumors specifically within the brain affects treatment response and to use this knowledge to develop more effective therapies for this deadly disease.

PI_NAMEs: MICHOR, FRANZISKA ;WHITE, FOREST M (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Adaptive Immune System;Address;Affect;Biological Models;Biopsy;Brain;career;cell type;Cells;Clinic;Collaborations;Complex;Computer Models;Cytotoxic Chemotherapy;Data;Development;Disease;driving force;dynamical evolution;effective therapy;Environment;Fostering;Foundations;Glioblastoma;Glioma;Goals;graduate student;Growth;Human;image registration;Immune;immune cell infiltrate;Immunologics;Immunooncology;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;in vivo Model;Individual;Infiltration;Innate Immune System;insight;Invaded;Knowledge;Lead;Malignant Neoplasms;Massachusetts;medical schools;Mentorship;migration;Modeling;Modernization;Molecular;multi-scale modeling;multiple omics;Nature;Necrosis;neoplastic cell;neural;Neuroepithelial, Perineurial, and Schwann Cell Neoplasm;Neurons;neurotransmission;next generation;novel;novel therapeutic intervention;Oncogenic;Operative Surgical Procedures;outreach;Pathway interactions;Patient Care;Patients;Phase 0 Clinical Trial;Phenotype;Phosphoproteins;predictive modeling;Primary Brain Neoplasms;programs;Proteins;Radiation therapy;Research;Research Project Grants;Resistance;response;Sampling;Secondary to;Signal Transduction;Stimulus;System;Systems Biology;Techniques;Technology;Testing;Therapeutic;Therapeutic Intervention;Time;Transcript;treatment response;tumor;tumor behavior;Tumor Biology;Tumor Burden;Tumor Cell Biology;Tumor Cell Invasion;tumor growth;tumor microenvironment;tumor progression;Universities

PROJECT_TITLE: Quantitative systems biology of glioblastoma cells and their interactions with the neuronal and immunological milieu


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Childhood Obesity;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

ORG_STATE: AR

PI_NAMEs: SWINDLE, TAREN  (contact)

PROJECT_TERMS: Academy;Address;Adult;Advocacy;Affect;age effect;Arkansas;Attention;beneficiary;Child Health;Communication;Communities;community advisory board;community building;community consultation;community engaged research;community engagement;community partners;Complex;Consultations;Data Collection;Development;Device or Instrument Development;Disease;disorder prevention;Disparity;dissemination strategy;early childhood;Educational workshop;effective intervention;Elements;Environment;Evaluation;evidence base;experience;Family;Feasibility Studies;Feedback;Funding;Geographic Locations;Geography;Goals;Health;Health Promotion;improved;Individual;Infrastructure;Institution;instrument;interest;Interpersonal Relations;Intervention;Lead;Literature;Lived experience;Medical;member;Mentors;Modeling;Obesity;obesity in children;obesity prevention;obesity risk;Ownership;Parents;Participant;Patients;Pediatric Research;Personal Satisfaction;Persons;Phase;Pilot Projects;Play;Population;prevent;Prevention Research;Process;programs;Provider;Public Health;Public Policy;recruit;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;Role;Schools;Science;Scientist;service engagement;Services;Time;Training;Training and Education;Training Programs;Translating;Translations;Trust;trustworthiness;Universities;Work

PROJECT_TITLE: Center for Childhood Obesity Prevention - Community Engagement Core


NIH_SPENDING_CATS: Back Pain;Chronic Pain;Clinical Research;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research

PI_NAMEs: TAVARES FERREIRA, DIANA  (contact)

PROJECT_TERMS: Age;Algorithms;analysis pipeline;Archives;ATAC-seq;Bar Codes;bioinformatics tool;Biological Assay;Cell Nucleus;cell type;Cells;chronic painful condition;clinical phenotype;Code;cohort;Collaborations;Communities;computational pipelines;Computer software;Data;Data Analyses;Data Coordinating Center;data format;data infrastructure;data management;Data Set;data sharing;data standards;Data Storage and Retrieval;database of Genotypes and Phenotypes;Databases;Decision Making;demographics;Detection;differential expression;DNA sequencing;Encyclopedias;Ensure;Excision;Experimental Designs;Genes;Genetic Markers;Genetic Transcription;Genotype-Tissue Expression Project;Goals;Grant;Helping to End Addiction Long-term;high throughput screening;Human;improved;Informatics;insight;interoperability;Laboratories;Low Back Pain;Maps;Metadata;Mission;Molecular;Molecular Profiling;nanopore;Neck Pain;Neurons;Neurosciences;Nociceptors;Organ Donor;Output;Pain;Pain Disorder;Pain management;painful neuropathy;Pathway interactions;Patients;Peripheral Nerves;peripheral pain;Phenotype;phenotypic data;Policies;Process;protocol development;Protocols documentation;Quality Control;Records;reference genome;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;Ribosomes;RNA;Secure;Services;sex;Site;Software Tools;Spinal Cord;Spinal Ganglia;Spine pain;Standardization;Synapses;System;Testing;Tissue imaging;tissue processing;Tissue Procurements;Tissues;tool;transcriptome;transcriptomics;United States National Institutes of Health;University of Texas M D Anderson Cancer Center;usability;Vision;web site;Work

PROJECT_TITLE: Data Core


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Boulder

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative  The average age of the population is increasing and with it the prevalence of age-associated cognitive decline. Physical activity (PA) is associated with lower risk for cognitive decline, but many people struggle to maintain PA over the long term, and most existing research on theory-based exercise interventions has been generated among high SES, low diversity samples. This study aims to take a community engaged research approach to develop and test a theory-based intervention to promote exercise maintenance using goal setting and exercise intensity among a vulnerable population (i.e., the Black community) as well as determine the extent to which psychological mediators explain the effects of these interventions on exercise maintenance and changes in biomarkers associated with cognitive decline.

PI_NAMEs: BRYAN, ANGELA  (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: acceptability and feasibility;Adherence;Adopted;Adult;Affect;Affective;African American;African American population;Age;age related;Age-associated memory impairment;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;American;Amyloid beta-Protein;Apolipoprotein E;Area;Awareness;Behavior;Benchmarking;Biological;Biological Markers;Black American;Black race;Cardiovascular Diseases;Chronic Disease;Code;Collaborations;Communities;community advisory board;community engaged research;community engagement;community partners;compliance behavior;Data;Demographic Factors;design;Development;Diabetes Mellitus;Disparity;economic cost;Effectiveness;Effectiveness of Interventions;efficacy testing;Equity;Ethnic Origin;Exercise;exercise adherence;exercise intensity;exercise intervention;exercise regimen;feasibility trial;Feedback;Genes;Genetic;Genotype;Goals;Guidelines;Health;Health behavior and outcomes;health disparity;human old age (65+);hyperphosphorylated tau;Immigrant;Immigrant community;Impaired cognition;Individual;Intervention;intervention effect;Intervention Trial;intrinsic motivation;Life Style;Light;Literature;Maintenance;Measures;Mediating;Mediator;meetings;member;Meta-Analysis;Methods;metropolitan;mild cognitive impairment;Moderate Exercise;moderate-to-vigorous physical activity;Morbidity - disease rate;mortality;neglect;neurofilament;Not Hispanic or Latino;Outcome;Participant;people of color;person centered;Persons;Phase;Physical activity;pilot trial;Plasma;Population;Prevalence;Prevention;Process;psychologic;Public Health;Race;randomized trial;Recommendation;recruit;Reporting;Research;Research Design;response;Risk;risk mitigation;Sampling;Self Efficacy;socioeconomics;Strenuous Exercise;Structural Racism;System;tau Proteins;tau-1;Techniques;Testing;theories;Translating;Treatment Efficacy;Underrepresented Populations;Vascular Dementia;vigorous intensity;Vulnerable Populations;Work;World Health Organization

PROJECT_TITLE: Exercise adherence and cognitive decline: Engaging with the Black community to develop and test a goal-setting and exercise intensity intervention


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

PI_NAMEs: WHITE, FOREST M (contact)

PROJECT_TERMS: Administrator;Advisory Committees;Brain Neoplasms;Businesses;Cells;Collaborations;Communication;Data;Development;dynamical evolution;Education and Outreach;Ensure;Evaluation;Glioblastoma;Goals;Immune;Immunologics;Immunosuppression;Institution;Invaded;Leadership;meetings;Modeling;Molecular;multiple omics;neoplastic cell;Neurons;novel therapeutic intervention;Office of Administrative Management;Pathway interactions;process improvement;Program Evaluation;Progress Reports;Reproducibility;Research;Running;Sampling;Site Visit;Solid Neoplasm;Source;symposium;System;Systems Biology;therapy resistant;tool;tumor;tumor microenvironment;tumor progression;web page;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Radiation Oncology;Rare Diseases

PI_NAMEs: AGAR, NATHALIE YR (contact)

PROJECT_TERMS: Affect;Aftercare;AMPA Receptors;Animals;anti-epileptic agents;Biological Process;Blood Vessels;Brain;Brain Neoplasms;cancer proteomics;Cell Communication;cell growth;cell motility;cell type;Cells;chemotherapy;Classification;Clinical Trials;clinically relevant;Clone Cells;cohort;Communication;Communities;Competence;Computer Models;Data;data integration;Dedications;deep learning;design;Development;dynamical evolution;Electrophysiology (science);Excision;Exhibits;experimental study;Extracellular Matrix;Favorable Clinical Outcome;Glioblastoma;Glioma;Glutamates;Heterogeneity;High Frequency Oscillation;Immunologics;in vivo;Individual;inhibitor;innovation;Invaded;Levetiracetam;Location;Logistic Regressions;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Glioma;Maps;Measurement;Measures;Metabolic;Metabolic Pathway;Microscopic;Mitochondria;Modeling;Molecular;Multiomic Data;multiple omics;Nature;neoplastic cell;Neuroepithelial, Perineurial, and Schwann Cell Neoplasm;neuronal tumor;Neurons;novel;Operative Surgical Procedures;Oxidative Phosphorylation;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Phenotype;pre-clinical;progenitor;Proliferating;Radiation therapy;random forest;Recurrence;Resected;Resistance;Resolution;Resources;response;Route;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Slice;Specimen;standard of care;Synapses;System;Systems Biology;Testing;Therapeutic;therapeutic development;therapy resistant;Time;Tissues;Treatment Efficacy;tumor;Tumor Markers;tumor metabolism;tumor progression;Tumor Promotion;tumorigenesis;white matter;Work

PROJECT_TITLE: Project 1:  Deciphering the Dynamic Evolution of the Tumor-Neural Interface


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Regenerative Medicine;Wound Healing and Care

ORG_CITY: EAST LANSING

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Non-healing chronic wounds (e.g., diabetic foot ulcers) affect millions of people in the US, but existing therapeutic options have limited efficacy. We propose to elucidate the functional role of crosstalk between Langerhans cells and epithelial cells in skin wound repair by using an innovative in vivo imaging system and novel genetic strategies. The results from this proposed research will have broad implications for understanding mechanisms underlying skin regeneration and inform the development of therapeutic targets for chronic wounds.

PI_NAMEs: PARK, SANGBUM  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: acute wound;Address;Affect;Aging;Antigens;Area;Behavior;Behavioral;burden of chronic illness;cell behavior;Cell Communication;cell motility;cell type;Cells;Cellular biology;chemokine;chronic wound;Communication;Data;Defect;Development;diabetic;Diabetic Foot Ulcer;diabetic ulcer;Disease;Disease Progression;effective therapy;Epidermis;Epithelial Cells;epithelial repair;epithelial wound;Epithelium;Foundations;genetic approach;Goals;Hair follicle structure;healthcare burden;Homeostasis;imaging system;Immune;immune function;Immune system;Immunity;Immunologics;in vivo;in vivo imaging system;Infection;injured;Injury;innovation;insight;intravital imaging;Knowledge;Langerhans cell;lymphatic vessel;Macrophage;Malignant Neoplasms;Mammals;migration;monocyte;Mus;Natural regeneration;Nature;neutrophil;novel;novel therapeutic intervention;obese person;Persons;Play;Population;prevent;Process;Recovery;recruit;Regenerative Medicine;repaired;Research;Role;Sentinel;Signal Transduction;single cell analysis;single-cell RNA sequencing;Site;Skin;skin barrier;Skin injury;skin regeneration;Skin repair;skin wound;stem cells;Stratified Epithelium;Surface;surveillance network;Testing;Therapeutic;therapeutic development;therapeutic target;tissue repair;Tissues;transcriptomics;uptake;Work;wound;wound healing;Wounded area

PROJECT_TITLE: Understanding immune-epithelial interactions during wound repair in live mammals

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: DK

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Disease;Microbiome;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Narrative It is not fully understood how risk factors contribute to Latinos’ high risks of developing nonalcoholic fatty liver disease (NAFLD) and its sequelae of non-alcoholic steatohepatitis (NASH), cirrhosis, and liver cancer. This study will examine metabolic products of diet in a large study sample of Latinos (Hispanic Community Health Study – Study of Latinos, N=16,415 adults from four US centers) with state-of-the-art imaging of subclinical liver fibrosis and steatosis. Based upon our results, diet and metabolome features that predict NAFLD may be translated into low-cost risk screening tests.

PI_NAMEs: BURK, ROBERT D;KAPLAN, ROBERT C (contact);KIZER, JORGE R;PRICE, JENNIFER COHEN

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Address;Adult;Affect;aged;Bacteria;biobank;Biological;Biological Markers;burden of illness;case control;Cirrhosis;Clinical;cohort;Cohort Studies;Collaborations;Consumption;contrast enhanced;cost;Data;data integration;density;Diabetes Mellitus;diabetes risk;Diet;Diet Modification;Disadvantaged;Disease;Disease Pathway;disorder prevention;disorder risk;Ensure;Environment;Epidemiology;Essential Amino Acids;extracellular;Fatty acid glycerol esters;Fatty Liver;Fibrosis;Fructose;Gastrointestinal tract structure;genetic association;Genetic Determinism;Genetic Risk;Genetic Variation;gut microbiome;High Prevalence;high risk;Hispanic;Hispanic Community Health Study/Study of Latinos;Human;Image;improved;Indoles;Inflammation;Infrastructure;inter-individual variation;Intervention Trial;Knowledge;Latin American;Latino;Latino Population;Letters;Life;Literature;Liver;Liver diseases;Liver Fibrosis;liver imaging;longitudinal analysis;Magnetic Resonance Imaging;Malignant neoplasm of liver;Measurement;Measures;Mendelian randomization;Metabolic;Metabolic Diseases;Metabolism;metabolome;metabolomics;metagenomic sequencing;Methodology;Methods;microbiome sequencing;migration;Minority Groups;minority subjects;Modification;Monitor;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Nonpharmacologic Therapy;novel;Obesity;pharmacologic;Pharmacotherapy;Population;Poverty;prevent;Prevention;preventive intervention;Prevotella;primary outcome;Production;Protons;Research;Research Design;response;Risk;Risk Factors;Risk Reduction;risk variant;Sample Size;Sampling;Sampling Studies;screening;secondary outcome;Serum;sex;Shapes;Stratification;Study of Latinos;study population;sugar;Testing;therapy design;Time;Translating;Tryptophan;Unhealthy Diet;Visit

PROJECT_TITLE: Epidemiology of diet, metabolism and non-alcoholic fatty liver disease in Hispanic/Latino adults

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ADMINISTERING_IC: HG

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: HONOLULU

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE The Pacific Center for Genome Research (PCGR) at the University of Hawaii at Manoa (UHM) is designed to advance Genomic Research workforce at a Minority Serving Institution (MSI) with a mission to serve historically underrepresented population in biomedical research, Native Hawaiians and other Pacific Islanders. We will support a multi-investigator, interdisciplinary team to develop two interrelated and highly innovative genomic research projects, along with three cores, namely, Administrative Core, Genomic Workforce Development Core, and Community Engagement Core. Through the proposed initiative, genomic research capacity will be substantially increased in Hawaii.

PI_NAMEs: DENG, YOUPING ;WU, LANG  (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: Address;African American population;Area;Asian Americans;Award;Biogenesis;Biomedical Research;Cancer health equity;career;career development;Centers of Research Excellence;Communicable Diseases;Communities;community based research;community engagement;community partners;Companions;Core Facility;Creativeness;Data;Data Science;design;Development;Diabetes Mellitus;Disease;disease disparity;disease prognosis;disorder risk;Disparity;Doctor's Degree;doctoral student;Ensure;Epidemiologist;epigenome;Ethnic Population;Etiology;experience;Faculty;feeding;Fostering;Foundations;Fruit;Funding;Genetic;Genome;genome resource;genome sciences;genomic data;Genomics;Germ Lines;Goals;Hawaii;Health;Health Benefit;health disparity;health equity;Health Occupations;health outcome disparity;Hispanic Populations;Human;human disease;improved;Individual;Infrastructure;innovation;Institution;Interdisciplinary Study;Investigation;Investments;Knowledge;Latino Population;Malignant neoplasm of lung;Malignant Neoplasms;member;Mentors;method development;microbiome;Minority-Serving Institution;Mission;Molecular;multi-ethnic;multidisciplinary;Native Hawaiian;Native Hawaiian or Other Pacific Islander;non-genetic;novel;Outcome;Pacific Islands;Population;Postdoctoral Fellow;precision nutrition;Productivity;Prognosis;programs;Research;Research Activity;research facility;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk Factors;Science;Scientist;senior faculty;skills training;synergism;Technology;Training and Education;Training Programs;undergraduate student;Underrepresented Populations;underserved community;Underserved Population;Universities;Workforce Development

PROJECT_TITLE: Pacific Center for Genome Research


NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Rare Diseases

PROJECT_TERMS: Address;Antigen Presentation;Antigens;B lymphoid malignancy;Biological;Biological Markers;Biological Models;biological systems;Cell Communication;cell growth;cell type;Cells;Chemicals;Clinical Trials;Coculture Techniques;Combination immunotherapy;Communication;Complex;Computer Analysis;Computer Models;Core Biopsy;Coupled;Critical Pathways;Cross Presentation;cytokine;Cytotoxic T-Lymphocytes;Data;data integration;Dendritic Cells;design;Development;Disease;draining lymph node;dynamical evolution;Engineering;Environment;Evolution;exhaust;Failure;Foundations;Genetic;Genomics;Geography;Glioblastoma;Goals;Human;Immune;Immune checkpoint inhibitor;Immune response;Immunologics;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;insight;Interphase;Knowledge;Lung;Maps;Measurement;Mediating;Melanoma;Modeling;Molecular;Molecular Analysis;Molecular Target;mouse model;multiple omics;Mus;Mutation;Myeloid Cells;Nature;neoplastic cell;Neurons;new therapeutic target;Pathway Analysis;Pathway interactions;Patient Care;Phenotype;phenotypic data;Phosphoproteins;Play;predictive modeling;programmed cell death ligand 1;Proteins;reconstruction;recruit;Repression;Resolution;Role;Signal Transduction;single-cell RNA sequencing;Specimen;success;System;Systems Biology;T-Lymphocyte;Techniques;Therapeutic;therapy outcome;therapy resistant;Time;Tissues;Transcript;Translating;translational goal;treatment response;treatment strategy;tumor;Tumor Cell Invasion;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor stage;Tumor Tissue;tumor-immune system interactions;tumorigenic

PROJECT_TITLE: Project 2:  Deciphering the Dynamic Evolution of the Tumor-Immune Interface


PI_NAMEs: WANKHADE, UMESH D (contact)

PROJECT_TERMS: Adipocytes;Adipose tissue;Blood Vessels;cold temperature;Country;Data;Exposure to;Gene Expression;Health;Housing;Immune response;Impairment;improved;Income;Inflammation;Inflammatory;Inflammatory Response;Intervention;Metabolic;Morphology;next generation;Obesity;obesity in children;obesity prevention;obesity risk;offspring;Outcome;parental role;Parents;Pilot Projects;Predisposition;programs;Public Health;Risk Reduction;Temperature;Weight Gain

PROJECT_TITLE: Impact of Parental Long Term Thermoneutral Ambient Temperature on Offspring Health


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research

PI_NAMEs: WU, LANG  (contact)

PROJECT_TERMS: Address;Administrator;Advisory Committees;Advocate;Budgets;Burn injury;Cancer Center;Cancer health equity;career development;Catchment Area;Centers of Research Excellence;Collaborations;college;Communication;Communities;community advisory board;Core Facility;Development;disease disparity;Disease Outcome;disorder risk;Employee;Ensure;Equipment;Equipment and supply inventories;ethnic difference;ethnic diversity;Evaluation;expectation;experience;Fostering;Foundations;Funding;Genome;Genomics;Goals;Grant;Growth;Hawaii;Human Resources;Individual;Infrastructure;innovation;Institution;Leadership;Maintenance;medical schools;meetings;member;Modification;Office of Administrative Management;operation;Pacific Islands;Patients;Play;Process;Productivity;Program Evaluation;programs;Progress Reports;Protocols documentation;Race;racial difference;Records;Regulation;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Resources;Role;Schools;Science;Senior Scientist;skills;Specific qualifier value;Strategic vision;Structure;Subgroup;success;survivorship;System;timeline;tool;Training;United States National Institutes of Health;Universities;webinar;Work


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Acetaminophen (APAP or paracetamol) is a commonly used medication by pregnant people; however, concerns have been raised over possible adverse effects of APAP on fetal development. We propose to conduct in-depth analyses using highly unique data sources from the Danish National Birth Cohort (DNBC) and investigate whether prenatal and postnatal exposures to APAP affect neurodevelopment from infancy through age 18. Our project will generate robust and scientifically rigorous data that can be used to inform regulatory recommendations and policymaking decisions for APAP and related medication use.

PI_NAMEs: LIEW, ZEYAN  (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Acetaminophen;Address;Adolescence;Adverse effects;Affect;Age;Aminophenols;Analgesic and Antipyretic;androgenic;Asia;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavioral;Birth;Brain;Child;Childhood;Clinical Trials;cognitive function;cohort;Cohort Studies;Consumption;craniofacial;Data;Data Sources;Databases;Decision Making;Development;Diagnosis;Disease;Dose;early life exposure;Enrollment;Ethics;Europe;executive function;experience;experimental study;Exposure to;fetal;Fetal Development;Fetal Growth;Fetus;Fever;Genetic Risk;Guidelines;Health;infancy;Intake;Interview;Investigation;Joints;Knowledge;Life;Link;Literature;maternal serum;Maternal-fetal medicine;Medical;Mental Health;Modeling;Mothers;Motor;multidisciplinary;neurobehavior;neurobehavioral disorder;neurodevelopment;neurodevelopmental effect;neuropsychiatry;Observational Study;offspring;Outcome;pain reduction;Performance;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Phenotype;Placenta;Policy Making;Polypharmacy;Population;postnatal;Pregnancy;pregnant;prenatal;prenatal exposure;prenatal influence;Property;prospective;Prospective, cohort study;Randomized;Recommendation;Records;Registries;Reporting;Research;Research Design;Research Project Grants;Review Literature;Risk;Role;Safety;Sampling;Schools;Societies;Symptoms;Systematic Bias;Time;time interval;United States Food and Drug Administration

PROJECT_TITLE: Neurodevelopmental Effect of Acetaminophen Exposures

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Networking and Information Technology R&D (NITRD);Neurosciences;Rare Diseases

PI_NAMEs: MICHOR, FRANZISKA  (contact)

PROJECT_TERMS: Adoption;Algorithms;analytical method;Automobile Driving;Bioinformatics;Biopsy;Brain Neoplasms;career;cell type;Cells;Clinical;clinical decision-making;clinical translation;Collaborations;Communication;Communities;Complex;Computational Biology;Computer Models;Coupled;Dana-Farber Cancer Institute;Data;data access;Data Set;Discipline;Disparate;dynamical evolution;Education;Education and Outreach;Educational Status;empowerment;experience;Exposure to;externship;Faculty;Faculty Workshop;Female;Fostering;Funding;Funding Opportunities;Future;Genetic;Glioblastoma;Goals;graduate student;high school;Histology;Human;Immersion;Immunologics;improved;insight;Institution;interdisciplinary collaboration;Internships;Learning;Lesion;Malignant Neoplasms;Modeling;Molecular;Neurons;new technology;Oncologist;outreach;Participant;Pathologist;Pathway interactions;Phosphoproteins;Pilot Projects;post-doctoral training;Postdoctoral Fellow;Process;programs;Proteins;Protocols documentation;Publications;Recruitment Activity;Research;Research Personnel;Resolution;Rotation;Sampling;Science;Scientist;Series;Site;Slide;Solid;STEM career;Students;summer internship;symposium;System;Systems Biology;teacher;Techniques;Therapeutic;Thinking;Time;tool;Training;training opportunity;Training Programs;Transcript;treatment response;tumor;tumor microenvironment;tumor progression;Tumor stage;undergraduate student;Underrepresented Populations;Vision;Visit;web site;Work

PROJECT_TITLE: Education and Outreach Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

PHR: PROJECT NARRATIVE There is an urgent national need to grow a strong genomic workforce which includes populations underrepresented in biomedical research. We propose a streamlined educational feeder pipeline called PoWER-G (Promotion of Workforce Employment and Readiness in Genomics) providing an innovative “on-the- degree” training and professional development platform which draws upon the substantial student diversity within the University of Hawaii system. Knowledge generated by this pilot project will lead to development of a formal 1-year Graduate Certificate Program to promote diversity in the genomic workforce and to continue to meet the exponential growth in genomics.

PI_NAMEs: BINGHAM, JON-PAUL  (contact)

PROJECT_TERMS: base;Bioinformatics;Bioinformatics Shared Resource;Biomedical Research;Cancer Center;career;Career Choice;career development;certificate program;Collaborations;Competence;Cultural Diversity;Data;design;Development;Diverse Workforce;Doctor of Philosophy;Education;education pathway;Educational Status;Employment;Ensure;ethnic diversity;experience;Future;Genome;Genomics;Goals;graduate student;Growth;Hawaii;in silico;Industrialization;innovation;instrument;interest;International;Knowledge;Learning;Link;literacy;Mentors;Mentorship;next generation sequencing;Outcome;outreach;Pathway interactions;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;precision medicine;programs;Readiness;Research;Research Support;Research Training;Resources;Running;Scientist;skills;Solid;Structure;Student recruitment;student retention;student training;Students;Supplementation;System;Technology;Training;Training Programs;undergraduate education;undergraduate research experience;undergraduate student;Underrepresented Populations;Universities;Workforce Development;Workplace

PROJECT_TITLE: Genomic Workforce Development Core


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: KINGSTON

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: Project Narrative Gender minority young adults (GMYA) experience unique stress related to their gender identity and/or expression, which may be amplified be amplified by current events like the ongoing COVID-19 pandemic and political actions to restrict the rights of GMYA, that can contribute to worse depression and anxiety compared to their cisgender counterparts. Evidence suggests increasing self-compassion among GM people could decrease depression and anxiety by reducing shame and rumination, but the full mindful self-compassion (MSC) intervention has yet to be tested among GMYA. If feasible and acceptable, MSC could be evaluated in a larger clinical trial for its ability to reduce the impact of gender minority stress on GMYA mental health.

PI_NAMEs: BOSSE, JORDON D. (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Adult women;adverse childhood events;Antidotes;Anxiety;anxiety reduction;Attention;Biology;Birth;bodily sensation;body dissatisfaction;Certification;cisgender;Clinical Trials;cohort;Communities;community engaged research;community intervention;Complementary Health;COVID-19 impact;COVID-19 pandemic;Data;Data Analyses;Data Collection;Disparity;Distress;Educational Curriculum;Educational process of instructing;Evaluation;Event;experience;feasibility trial;Feeling;Feeling suicidal;Female;follow-up;Fostering;Funding;Gender;gender dysphoria;gender expression;Gender Identity;gender minority;gender minority group;gender minority stress;Goals;health disparity;Health Promotion;high risk;improved;Integrative Medicine;interest;Intervention;man;Mental Depression;Mental Health;Mentors;Methods;Mind-Body Intervention;mindfulness;minority stress;modifiable risk;mortality;National Center for Complementary and Integrative Health;nonbinary;Pain;Participant;Personal Satisfaction;Persons;Politics;Population;Population Heterogeneity;post intervention;protective factors;Recording of previous events;Reporting;Research;resilience;response;Rights;Risk;Risk Factors;rumination;satisfaction;Science;self-compassion;sex;sex assigned;sexual minority group;Shame;Site;skills;social stigma;Source;Stigmatization;Stress;stress reduction;symptom management;teacher;Teenagers;Testing;Thinking;Time;Training;trait;Trauma;university student;usability;Vulnerable Populations;Woman;young adult

PROJECT_TITLE: Evaluating the Feasibility and Acceptability of Mindful Self-Compassion Among Gender Minority Young Adults


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Rare Diseases

PI_NAMEs: SARKARIA, JANN N. (contact)

PROJECT_TERMS: Animal Experiments;Animal Model;Animals;Archives;bench to bedside;biobank;Biological;Biological Models;biological specimen archives;Brain;Brain Neoplasms;Categories;Cells;Clinic;Clinical Trials;clinically relevant;Collaborations;Collection;Complex;Coupled;design;Ensure;experience;experimental study;Future;Genetically Engineered Mouse;Glioblastoma;Goals;Human;image registration;Immunologics;in vivo;Intracranial Neoplasms;Laboratories;Modeling;neoplastic cell;neuro-oncology;Neurons;Neurosurgeon;Organoids;patient derived xenograft model;Patients;pharmacologic;Pilot Projects;pre-clinical;preclinical study;prospective;quality assurance;Research Project Grants;Research Support;Resources;Retrieval;Sampling;Scientist;Signal Transduction;Slice;Specimen;System;Systems Analysis;Systems Biology;Tissues;Translations;tumor;tumor microenvironment;Work;Writing

PROJECT_TITLE: Core 1:  Biospecimens Core


NIH_SPENDING_CATS: Atherosclerosis;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: NARRATIVE / PUBLIC HEALTH RELEVANCE STATEMENT The Community Engagement Core (CEC) will provide the oversight needed to ensure the U54 Pacific Center for Genome Research (PCGR)’s consideration of equity and ethics in the examination of genetic and other risk factors across the underserved and ethnic minority groups, including Native Hawaiians (NHs), Africans, Latinos, Asians, and Europeans served by this research. The CEC will broadly engage these populations and their providers to increase their awareness of genetic and omic risks for disease and obtain their input on our research. The CEC activities will support the dissemination of findings from the two PCGR projects includingProject 1, to better characterize roles of genetically predicted DNA methylation, gene expression, protein expression, and metabolite levels in the blood tissue and known non-genetic risk factors in influencing risks of multiple diseases across NHs, Africans, Latinos, Asians, and Europeans, and Project 2, to characterize genomic risk factors of lung cancer in NHs.

PI_NAMEs: CASSEL, KEVIN DARRYL (contact)

PROJECT_TERMS: African;Architecture;Arterial Disorder;Asian;Asian population;Atherosclerosis Risk in Communities;Awareness;biobank;Biological Markers;Blood;Cancer Burden;Clinical;Communities;community advisory board;community engagement;Community Health Education;community organizations;Community Relations;Complex;Data;Disease;disorder prevention;disorder risk;DNA Methylation;Education;Educational Activities;Educational workshop;Ensure;Epidemiology;epigenomic profiling;epigenomics;Equity;Ethics;ethnic minority population;Ethnic Population;European;experience;Focus Groups;Foundations;Framingham Heart Study;Future;Gene Expression;General Population;Genetic;genetic epidemiology;genetic predictors;Genome;Genomics;Goals;Hawaii;high risk;Infrastructure;interest;Investigation;Latino;Latino Population;Malignant neoplasm of lung;Medical;medically underserved;member;Methods;Minority Groups;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;Native Hawaiian;non-genetic;Pacific Islands;Participant;Physicians;Play;Population;predictive modeling;Prevention Research;protein expression;Protocols documentation;Provider;public health relevance;recruit;repository;Research;Research Project Grants;Resources;Risk;Risk Factors;Risk Marker;Role;Series;student training;Students;success;Tissues;Training and Education;Translational Research;Underrepresented Minority;underserved community;underserved minority;Underserved Population;Universities;Work;Workforce Development

PROJECT_TITLE: Community Engagement Core


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Data Science;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_CITY: Auburn

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: NARRATIVE The proposed project is relevant to public health because correctly identifying and characterizing cancer subtypes is key to improving the accuracy of prognoses and making treatments more effective. This project will create a complete analysis pipeline and web application able to integrate multi-omics studies, discover molecular subtypes, visualize subtypes’ pathway signatures, which could potentially be targets for therapeutic interventions. This tool will greatly enhance the cancer research community’s capacity for patient stratification and characterization by allowing the vast amount of data stored on public and private repositories to be used more efficiently than is currently possible.

PI_NAMEs: LUU, HUNG N;NGUYEN, TIN C (contact)

PROGRAM_OFFICER_NAME: GUAN, PING

PROJECT_TERMS: Address;analysis pipeline;anti-cancer research;Apoptosis;Automobile Driving;Breast Cancer Patient;cancer cell;Cancer Center;cancer health disparity;cancer subtypes;cancer therapy;Case/Control Studies;Characteristics;Clinical;Clinical Research;clinically relevant;cohort;Communities;Copy Number Polymorphism;Data;Data Set;Defense Mechanisms;Development;Disease;Epidermal Growth Factor Receptor;epigenome;ERBB2 gene;ESR1 gene;Event;Gene Expression;Genes;Genetic;genetic signature;Goals;Hospitals;improved;Individual;individual patient;Inhibition of Apoptosis;innovation;Knowledge;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Medicine;Methodology;Methods;Methylation;MicroRNAs;Modeling;Molecular;molecular subtypes;molecular targeted therapies;mRNA Expression;Mucinous Neoplasm;Multiomic Data;multiple omics;Mutation;novel strategies;Oncogenes;overexpression;Pancreas;pancreatic cancer patients;Papillary;Pathway Analysis;Pathway interactions;patient oriented;patient prognosis;patient stratification;patient subsets;Patients;personalized medicine;Privatization;Process;Prognosis;Proliferating;prototype;public database;Public Health;repository;Resistance;Resistance development;response;Rest;risk prediction;risk stratification;Sample Size;Sampling;self supervised learning;Signal Transduction;Solid Neoplasm;Subgroup;System;targeted treatment;Testing;Therapeutic Intervention;Time;tool;transcriptome;transfer learning;tumor;Visualization;web app;Work

PROJECT_TITLE: Personalization of graphical models using multi-omics data for subtype discovery and prognosis


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Rare Diseases

PROJECT_TERMS: accurate diagnosis;Affect;Agar;Animal Model;Biological;Biology;Brain Neoplasms;brain tissue;Cell Communication;Cell Culture Techniques;Cell Nucleus;cell type;Cells;Clinical;Clinical Research;clinically relevant;Complex;Core Biopsy;Cryoultramicrotomy;Data;data management;data sharing;Dimensions;drug distribution;dynamical evolution;Ensure;Equipment;Experimental Models;Expression Profiling;forest;Gene Expression;Gene Expression Profiling;Geography;Glioblastoma;Glioma;Goals;Human;Human Resources;human tissue;Image;image guided;imaging biomarker;Immune;Immunologics;In Vitro;information gathering;Knowledge;Malignant - descriptor;Maps;mass spectrometric imaging;mathematical model;Measurement;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Metadata;Methodology;Methods;MHC Class I Genes;Modeling;Molecular;Molecular Profiling;Multiomic Data;neoplastic cell;Neuroglia;Neurons;Patients;Peptides;Performance;Pharmaceutical Preparations;phosphoproteomics;Phosphorylation;Population;pre-clinical;Pre-Clinical Model;programs;protein expression;Proteomics;Protocols documentation;Quality Control;Reagent;Reproducibility;Resolution;Resources;Sampling;Services;Signal Transduction;single nucleus RNA-sequencing;spatial integration;Specimen;Study models;System;Systems Biology;Technology;Therapeutic;Thick;Time;tissue culture;Tissues;tool;transcriptome sequencing;transcriptomics;treatment response;tumor;tumor microenvironment

PROJECT_TITLE: Core 2:  Analytical Core


NIH_SPENDING_CATS: Atherosclerosis;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE There are urgent needs to identify causally related methylation, gene, protein, and metabolite biomarkers in blood for risk of multiple human diseases across multi-ethnic populations. The proposed study will identify causally related omic biomarkers for multiple diseases using an innovative design and evaluate interactions between newly identified and established markers and known non-genetic risk factors on influencing disease risk. Knowledge generated by this project will significantly contribute to the etiologic understanding of human diseases.

PROJECT_TERMS: Address;African;African American population;Alzheimer's Disease;American;Architecture;Arterial Disorder;Asian Americans;Asian population;Assessment tool;Atherosclerosis Risk in Communities;Basic Science;biobank;Biological Markers;biomarker identification;Blood;Cohort Studies;Communities;Data;design;Development;Disease;Disease Marker;disorder risk;Disparity;DNA Methylation;epidemiologic data;Epidemiology;epidemiology study;Ethnic Origin;Ethnic Population;Etiology;European;European ancestry;Framingham Heart Study;Gene Expression;Genes;Genetic;genetic epidemiology;Genetic Markers;genetic predictors;genetic risk factor;genetic variant;Genome;Genomics;Goals;Hispanic Populations;human disease;improved;Individual;innovation;instrument;interest;Knowledge;Latino Population;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Measures;Methodology;Methods;Methylation;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;Native Hawaiian;non-genetic;novel;novel marker;Participant;Population;Population Group;predictive modeling;programs;protein expression;protein metabolite;Proteins;Reduce health disparities;Reporting;Research;Research Design;Research Support;Risk;Risk Factors;risk prediction;Role;Selection Bias;Series;Site;Statistical Methods;statistics;Testing;Tissues;Training;trait;Veterans;Work;Workforce Development

PROJECT_TITLE: Integrating genome, other layers of omics, and non-genetic data to improve understanding of the etiology of human diseases in multi-ethnic populations


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Women living with HIV (WLH) have a greater risk of developing invasive cervical cancer due to greater incidence and longer persistence of high-risk human papillomavirus infection. The primary objectives of this NCI K01 proposal are to: (1) conduct formative research and pilot test the provider-level and patient-level components of the My Self-Sampling for HPV Awareness, Results, and Empowerment (MySHARE+) intervention to increase cervical cancer screening (HPV self- collection; Pap triage adherence) among under/never-screened WLH and (2) provide Dr. Le with didactic training, directed mentorship, and experiential learning opportunities to develop cancer prevention and control research methods skills and content expertise in quasi-experimental studies and cluster-RCTs using multilevel approaches, digital health/technology- based interventions to promote patient-centered care, and implementation science methodologies and frameworks. This career development award will undoubtedly enable the candidate to comprehensively and systematically expand her multidisciplinary research training and effectively facilitate her successful progression towards independence as a behavioral health researcher with an extramurally-funded program in evidence-based bio-behavioral interventions to reduce cancer health disparities.

PI_NAMEs: LE, DAISY  (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Acceleration;acceptability and feasibility;Active Learning;Address;Adherence;Adoption;AIDS prevention;Appointments and Schedules;Area;Award;Awareness;Behavior;behavioral health;biobehavior;Cancer Burden;Cancer Control;Cancer Control Research;Cancer Detection;cancer health disparity;cancer prevention;career;Caring;cervical cancer prevention;Cervical Cancer Screening;cervicovaginal;Cities;Clinic;Clinical;Cluster randomized trial;Collaborations;Collection;Communities;comparison control;Complex;Control Groups;cost;Cues;Data;digital health;disparities in women;Early Diagnosis;Education;Educational Intervention;electronic medical record system;Eligibility Determination;empowerment;Enhancement Technology;Enrollment;evidence base;Extramural Activities;Faculty;follow-up;Funding;Future;Goals;Government;Guidelines;Health;health care availability;health care delivery;health disparity;health information technology;Health Personnel;high risk;HIV;HIV diagnosis;Home;HPV positive;HPV screening;HPV-High Risk;Human papilloma virus infection;Human Papillomavirus;Human Resources;implementation science;improved;Incidence;Infection;innovation;Institution;Instruction;Intention;Interdisciplinary Study;Intervention;Intervention Studies;Interview;Intraepithelial Neoplasia;K-Series Research Career Programs;Knowledge;Location;Malignant neoplasm of cervix uteri;Malignant Neoplasms;marginalized population;Measures;meetings;Mentors;Mentorship;Methodology;Methods;mHealth;mhealth interventions;Mission;Modality;Outcome;participant enrollment;Patient Education;Patient-Centered Care;patient-clinician communication;Patients;Persons;pilot test;Pre-Post Tests;preference;Preventive screening;primary care provider;primary care setting;primary health service;primary outcome;programs;Provider;Quasi-experiment;Randomized;Recommendation;Records;recruit;remote delivery;Reporting;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Research Support;Research Training;Risk;Sampling;Scientific Advances and Accomplishments;screening;screening disparities;Screening for cancer;secondary outcome;Security;Self Efficacy;self testing;shared decision making;skills;social;Speculums;Surveys;System;Technology;technology intervention;Testing;Text Messaging;tool;Training;Training Activity;Transportation;Triage;uptake;Visit;Vulnerable Populations;Wait Time;Woman;women's prevention;World Health Organization

PROJECT_TITLE: A Technology-enhanced and Multilevel Approach to Promote Cervical Cancer Prevention Among Women Living with HIV

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Lung Cancer;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

PHR: Project Narrative Lung cancer is the second most common cancer in the United States and the leading cause of cancer-related deaths, with Native Hawaiians (NHs) having not just the greatest risk of lung cancer but also the poorest survival outcome when compared with other populations. We propose to conduct a genomic and epigenomic profiling study to help understand the health disparities of NH population in lung cancer risk. This project has the potential to be translated into improved lung cancer screening, precision prevention, and therapeutic intervention in NH and other populations, besides enabling us to train students, researchers, and community workers with fundamental genomic technologies such as whole genome DNA sequencing, a useful technology for conducting biomedical research in any human diseases.

PI_NAMEs: DENG, YOUPING  (contact)

PROJECT_TERMS: Accounting;Address;African American;African American population;Asian population;Behavior;Bioinformatics;Biomedical Research;bisulfite sequencing;Cancer Etiology;cancer genome;cancer genomics;cancer health disparity;cancer immunotherapy;Cancer Patient;cancer risk;Cells;Cessation of life;Clinical;Communities;community engagement;Community Workers;comparative;Copy Number Polymorphism;Data;Data Analyses;Data Science;Development;Disease;Disparity;DNA;DNA Methylation;DNA sequencing;driver mutation;Epidermal Growth Factor Receptor;Epigenetic Process;epigenomic profiling;epigenomics;ethnic diversity;Ethnic Origin;Ethnic Population;exome sequencing;Formalin;Freezing;Frequencies;Gene Mutation;Genes;genetic signature;Genome;genome sequencing;genome-wide;genomic data;genomic profiling;Genomics;Germ-Line Mutation;Hawaiian population;health disparity;high risk;human disease;improved;Incidence;International;Latino Population;lung cancer screening;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Methylation;Modification;Molecular;Molecular Profiling;Mutate;Mutation;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Normal tissue morphology;novel;Outcome;Pacific Islander;Paraffin Embedding;Patients;personalized intervention;Population;Population Heterogeneity;preventive intervention;profiles in patients;Proteomics;Publishing;Race;racial disparity;racial diversity;Research;Research Design;Research Personnel;response;Risk;Risk Factors;sample fixation;Sampling;skills;Smoking;Somatic Mutation;student training;survival outcome;Technical Expertise;Technology;The Cancer Genome Atlas;Therapeutic Intervention;Tissue Sample;Tissues;Translating;tumor;United States;whole genome;Workforce Development

PROJECT_TITLE: Characterizing genomic risk factors of lung cancers in Native Hawaiians


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Neonatal Respiratory Distress;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Bronchopulmonary dysplasia (BPD) is the most common respiratory sequelae of prematurity and is often fatal. While very few treatment options exist that safely reduce BPD, montelukast is FDA-approved and already shows promise in small neonatal trials. Because of limited pharmacokinetic (PK)/pharmacodynamics (PD) research, the optimal montelukast dose for premature infants to avoid BPD is unknown; leveraging an experienced team, the PRISM PK/PD trial will determine the optimal dose of montelukast to reduce BPD.

PI_NAMEs: GONZALEZ, DANIEL ;LANG, JASON E. (contact);LAUGHON, MATTHEW

PROGRAM_OFFICER_NAME: TAYLOR-ZAPATA, PERDITA

PROJECT_TERMS: Adrenal Cortex Hormones;Adverse event;Age;Age Months;Alveolar;Anti-Inflammatory Agents;Bronchopulmonary Dysplasia;Childhood;Clinical;cohort;Data;design;Development;Diffuse;Doctor of Pharmacy;Doctor of Philosophy;Dose;drug clearance;Drug Kinetics;Edema;efficacy trial;experience;FDA approved;Fibrosis;Frequencies;Gestational Age;Health Care Costs;high risk;Hospitalization;Hyperoxia;Impairment;improved;indexing;Infant;Inflammation;Inflammatory;Lead;Leukotriene Receptor;Leukotrienes;Life;Linear Regressions;Maintenance;Measures;Modeling;montelukast;National Institute of Child Health and Human Development;Nature;Neonatal;neonatal care;Neonatology;neurodevelopment;open label;Oral;overtreatment;oxygen toxicity;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacometrics;Phase;phase III trial;Placebos;Population;postnatal;pre-clinical;Pregnancy;premature;Premature Infant;pressure;Prevalence;prevent;primary outcome;Production;Public Health;pulmonary function;Pulmonary Inflammation;Pulmonary Surfactants;Quality of life;Recording of previous events;Research;Research Personnel;Resort;respiratory;response;Risk;Risk Reduction;Safety;secondary outcome;Severity of illness;side effect;Site;stem;Testing;Therapeutic;Training;Trauma;treatment duration;trend;ventilation;Ventilator

PROJECT_TITLE: PRISM


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Social Determinants of Health;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Significant resources are being invested to implement quality improvement initiatives in birthing hospitals across the country. There is great need to evaluate these efforts and demonstrate their effectiveness in reducing the burden of preventable severe maternal morbidity (SMM) and maternal deaths. This study will develop and validate a refined comorbidity index for obstetric patients that allows SMM rate comparisons across hospitals and adequate monitoring of obstetric quality improvement initiatives.

PI_NAMEs: CREANGA, ANDREEA ALINA (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;Admission activity;Affect;Algorithms;American College of Obstetricians and Gynecologists;Area;Area Under Curve;Birth;blood product;Calibration;Caring;Centers for Disease Control and Prevention (U.S.);Certification;Characteristics;Clinical;clinical practice;community partners;comorbidity;comorbidity Index;Country;Data;Data Analyses;Data Sources;data standards;Diagnosis;Discipline of obstetrics;Discrimination;Effectiveness;Electronic Health Record;Evaluation;Event;Goals;Guidelines;Health Care Costs;health care delivery;health data;Health system;high risk;Hospitals;improved;indexing;Individual;innovation;Inpatients;Intensive Care Units;International Classification of Disease Codes;Investments;Machine Learning;Maryland;Maternal Health;Maternal Health Services;Maternal Mortality;Maternal-fetal medicine;Measures;Medical;meetings;Monitor;Outcome;Outcome Measure;patient population;patient safety;Patients;Peer Review;Performance;Perinatal Care;predictive modeling;Pregnancy;Process;Professional Organizations;Prognosis;Program Evaluation;Property;Psychometrics;Publishing;Receiver Operating Characteristics;Recommendation;Reporting;Research;Resources;Review Literature;Risk;Risk Adjustment;Sampling;severe maternal morbidity;Societies;sociodemographic group;Structure;System;Techniques;Testing;Time;Transfusion;trend;Triage;United States;virtual;Work

PROJECT_TITLE: Developing a refined comorbidity index for use in obstetric patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Los Angeles

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Narrative Alzheimer’s disease (AD) remains one of greatest unmet medical needs in our country with estimates of over 5 million Americans suffering from the disease in 2016 with no new symptomatic therapies having been approved over the past 12 years, and currently no approved disease-modifying agents. The timeframe, complexity, and expense of the recruitment process and site activation for AD trials are extremely challenging, and indeed trial enrollment and site network development represent a bottleneck for drug development for the AD field; there is a growing consensus that we must fundamentally overhaul the current clinical trial recruitment and assessment structure. This proposal aims aim to create an optimized infrastructure to optimally design, efficiently launch, rapidly recruit with improved diversity, and successfully complete NIH supported clinical trials in AD and related dementias.

PI_NAMEs: AISEN, PAUL S. (contact);PETERSEN, RONALD C;SPERLING, REISA A.

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Acceleration;Address;Agreement;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;American;Amyloid;Amyloid beta-Protein;asymptomatic Alzheimer's disease;Autopsy;Benchmarking;biobank;Biological Markers;Biometry;Blood;Brain;Clinic;Clinical;Clinical Investigator;Clinical Research;clinical trial participant;clinical trial recruitment;Clinical Trials;Clinical Trials Unit;Cognitive;cognitive testing;Collaborations;Communities;Computer software;computerized;Consensus;Contracts;Country;Data;Data Analyses;data management;data sharing;Decision Making;design;Development;digital;Disease;drug development;Education;effective therapy;electronic data capture system;Enrollment;equity, diversity, and inclusion;evidence base;Excision;Expenditure;experience;follow-up;Fostering;Funding;Future;Goals;Image;Immunoassay;Improve Access;improved;Informatics;Information Systems;Infrastructure;innovation;Institutional Review Boards;instrument;Intervention;Justice;Leadership;Learning;Magnetic Resonance Imaging;Mass Spectrum Analysis;Measures;Medical;Mentors;Mentorship;Methods;Mission;Multicenter Trials;neurodegenerative dementia;Neurodegenerative Disorders;neuroimaging;neuropathology;next generation;novel;novel strategies;open data;operation;Outcome;Outcome Measure;Participant;Performance;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Plasma;Population;Population Heterogeneity;Positron-Emission Tomography;pragmatic trial;pre-clinical;Primary Prevention;Privatization;Procedures;Process;programs;Protocols documentation;public-private partnership;recruit;Registries;Research;Research Design;Research Personnel;Resources;Safety;Sampling;screening;Screening procedure;Signal Transduction;Site;Slide;small molecule;Specimen;Statistical Data Interpretation;Structure;success;tau Proteins;tau-1;Therapeutic;Therapeutic Trials;Tissue Banks;Training;trial design;trial enrollment;Trust;U-Series Cooperative Agreements;Underrepresented Populations;United States National Institutes of Health;user-friendly;Work

PROJECT_TITLE: Alzheimer's Clinical Trials Consortium (ACTC)


ADMINISTERING_IC: HS

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE The suicide rates among U.S. military service members and Veterans (MV) remain alarmingly high. The current study’s goals are to apply innovative machine learning (ML) to large MV suicide datasets to (1) establish ML algorithms detecting suicide ideation (SI) and suicide attempt (SA) at different military statuses to proactively inform clinicians and (2) develop an SI/SA longitudinal risk data-visualization profile for clinicians. We harness big data and innovative ML applications to provide a 360-degree view of MV, promoting safer, higher quality, more accessible, equitable, and affordable healthcare means by providing clinicians an evidence-informed tool to proactively, effectively, and efficiently detect SI/SA risk levels among MV clients.

PI_NAMEs: CHIU, CHUNG-YI  (contact);GAO, XIAOTIAN

PROGRAM_OFFICER_NAME: SWIGER, JAMES

PROJECT_TITLE: A longitudinal machine learning approach providing clinicians timely detection to prevent military suicide

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Frequent HIV testing among persons at higher risk of HIV infection is crucial for facilitating early treatment initiation for those who have become HIV-positive and for supporting engagement in appropriate HIV prevention interventions for those who test HIV-negative. However, in many countries with high HIV prevalence there is insufficient retesting among persons at higher risk. This project will use innovative methods to adapt, test and compare multiple low-cost behavioral interventions to increase HIV retesting among adults in rural Kenya and Uganda, with the goal of identifying interventions that can be rapidly implemented at scale.

PI_NAMEs: CHAMIE, GABRIEL  (contact);THIRUMURTHY, HARSHA

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Acceleration;Address;Adult;Africa South of the Sahara;AIDS prevention;antiretroviral therapy;Architecture;arm;Attention;Behavior;behavior test;Behavior Therapy;Behavioral;behavioral economics;Belief;Characteristics;Communities;comparison intervention;Control Groups;cost;Country;Decision Making;design;Diagnosis;Early Diagnosis;Early treatment;Educational workshop;Effectiveness;effectiveness evaluation;Enrollment;experimental arm;experimental study;Feedback;financial incentive;Future;Goals;group intervention;Guidelines;Health behavior;Health Personnel;heuristics;high risk;HIV;HIV diagnosis;HIV Infections;HIV risk;HIV Seronegativity;HIV Seropositivity;human centered design;Human immunodeficiency virus test;implementation intervention;implementation outcomes;Individual;Infection;Infrastructure;innovation;insight;Intervention;intervention cost;Kenya;machine learning method;Maps;Measures;men;Methods;Modeling;Morbidity - disease rate;novel;opportunity cost;Outcome;personalized approach;Persons;Population;pre-exposure prophylaxis;Prevalence;Prevention;preventive intervention;primary outcome;Process;prototype;Psyche structure;psychologic;Randomized;randomized trial;Recommendation;Research;Review Literature;Risk;Rural;Sample Size;scale up;Scientist;smoking cessation;social stigma;Specific qualifier value;stem;structural determinants;study population;Subgroup;Testing;Time;transmission process;treatment effect;Uganda;Vaccination;Work;young woman

PROJECT_TITLE: Transformative approaches to rapidly and efficiently test demand creation interventions to promote HIV retesting in adults at increased risk of HIV

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pain Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Autistic people may experience more persistent pain but may have more difficulty communicating their pain. In this project, we aim to identify better pain measurement for autistic adults and to understand factors that may result in more pain for autistic people. We will also examine how the brain may respond differently to pain in autistic adults with the aim of identifying new targets of pain treatment for autistic individuals.

PI_NAMEs: FAILLA, MICHELLE DAWN (contact)

PROGRAM_OFFICER_NAME: HARDY, KRISTINA KOREN

PROJECT_TERMS: Address;Adult;adult with autism spectrum disorder;Affect;Affective;analog;Anterior;Anxiety;autism spectrum disorder;autistic;Behavior;Brain;Brain region;clinically relevant;Clothing;Communication;Communication difficulty;Consensus;Data;Diagnosis;emotional factor;Emotions;Evaluation;experience;Facial Pain;Functional Magnetic Resonance Imaging;General Population;Health;Hypersensitivity;improved;Individual;Individual Differences;individuals with autism spectrum disorder;Injury;Insula of Reil;Intervention;Literature;Maps;Measurement;Measures;neural;Nociception;Pain;Pain Assessment Tool;pain behavior;Pain management;Pain Measurement;pain perception;pain processing;pain scale;pain sensitivity;Participant;Patient Self-Report;Persistent pain;Persons;pressure;Proxy;Psychophysics;Reaction;Recommendation;Reporting;Research;response;Risk;Sensory;Signal Transduction;social communication;social factors;somatosensory;Somatosensory Cortex;Stimulus;System;Tactile;Testing;verbal;Visual;Work

PROJECT_TITLE: Measurement and Mechanisms of Pain in Autistic Adults

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative  This project will use computational modeling, behavioral measurements, ultra-high-field (7 tesla) functional magnetic resonance imaging (fMRI) and human intracranial electroencephalography (iEEG) to quantify the role of human posterior superior temporal sulcus and gyrus (STS/G) in audiovisual speech perception. We theorize that neural computations performed in the STS/G are the basis for the uniquely human ability to combine auditory information from the voice and visual information from the face of the person we are communicating with. A better understanding of STS/G has the potential to benefit the millions of Americans who suffer from impaired communication due to stroke or hearing loss.

PI_NAMEs: BEAUCHAMP, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Acoustics;Adult;American;Anatomy;Area;audiovisual speech;Auditory;Auditory Perception;auditory stimulus;behavior measurement;Behavioral;behavioral study;Brain;Brain Injuries;Calibration;Communication;Communication impairment;Computer Models;Computer software;Crowding;Data;Development;Educational process of instructing;Electroencephalography;Epilepsy;experience;experimental study;Exposure to;Face;fascinate;Frequencies;Functional Magnetic Resonance Imaging;Future;Goals;Health;Hearing;hearing impairment;Human;Illusions;Impairment;Implanted Electrodes;improved;Individual;instrument;Intractable Epilepsy;Judgment;Knowledge;Language Disorders;Learning;lens;Masks;Measures;Medical;Modality;Modeling;Modification;multisensory;neural;neural correlate;neuromechanism;Neurons;Neurosciences;pandemic disease;Participant;Patients;Pattern;Perception;Personal Satisfaction;Persons;Phase;Population;Publishing;Records;Research;response;Role;Sensory;sensory input;sensory integration;Signal Transduction;social;Solid;Speech;Speech Perception;speech processing;Stimulus;Stroke;Structure of superior temporal sulcus;Techniques;temporal measurement;Testing;theories;Time;tool;Videoconferencing;Visual;visual information;visual speech;Voice

PROJECT_TITLE: Neural substrates of optimal multisensory integration

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Prevention;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PI_NAMEs: ALEXANDROV, LUDMIL B (contact);GUTKIND, JORGE SILVIO ;LIPPMAN, SCOTT M

PROGRAM_OFFICER_NAME: WANG, WENDY

PROJECT_TERMS: Address;Alcohol consumption;anti-cancer;Atlases;Automobile Driving;biobank;Bioinformatics;bioinformatics pipeline;cancer initiation;CD3 Antigens;Cd68;CD8B1 gene;Cells;Chromosomal Gain;Chromosomal Instability;Clinical;cohort;Data;Development;Diagnosis;Disease;DNA Sequence Alteration;driver mutation;Epidemiology;Epithelium;Evaluation;Event;exome;exome sequencing;Formalin;Gene Expression;General Population;Genetic;Genome;genomic data;Genomics;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Histologic;HPV negative;HPV-negative head and neck cancer;Human Papillomavirus;Immune;Immunofluorescence Immunologic;Immunogenetics;immunogenic;Immunogenomics;Immunologic Surveillance;immunoregulation;Infection;Intercept;Knowledge;Lesion;Leukoplakia;Malignant - descriptor;Malignant Conversion;malignant mouth neoplasm;Malignant Neoplasms;Maps;Mediation;Modeling;Molecular;molecular marker;Morphology;mouse model;mouth squamous cell carcinoma;Mutation;Natural History;neoplastic;novel;Oral;oral carcinogenesis;Oral Leukoplakia;oral premalignancy;oral tissue;Paraffin Embedding;Patients;Persons;Population;predictive marker;premalignant;Prevention;Process;prognostication;programmed cell death ligand 1;Prospective cohort;Records;Resolution;Risk;Risk Factors;Role;Sampling;Screening for Oral Cancer;Structure;Subgroup;Surveys;Tissues;Tobacco use;transcriptome;transcriptome sequencing;transcriptomics;Tumor Immunity;Whole Blood

PROJECT_TITLE: Mapping immuno-genomic drivers of the head and neck precancer invasive-disease transition


NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Behavioral and Social Science;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Hispanics/Latinos suffer from higher risk of diabetes than non-Hispanic whites, but little is known about the mechanism behind this disparity. Leveraging the rich clinical data collected by the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), this project seeks to examine how sociocultural, psychosocial, and lifestyle risk and resilience factors affect aging and risk of diabetes. Such results will greatly enhance our understanding of the mechanisms through which socioenvironmental factors contribute to aging and diabetes, and hold promise for precision prevention and intervention tailored to Hispanics/Latinos.

PI_NAMEs: ZHAO, JINYING  (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Aberrant DNA Methylation;Affect;African American population;age acceleration;age-related disease;aged;Aging;aging related;American Indians;Ancillary Study;bead chip;Behavior;Behavioral;Biological;bisulfite;Blood;Body mass index;cardiometabolism;Central American;Clinical;Clinical Data;clinical phenotype;cohort;Communities;Cuban;Data;design;Diabetes Mellitus;Diabetes prevention;diabetes risk;Disease;Disparity;DNA;DNA Methylation;Dominican;Epidemiology;Epigenetic Process;Equation;Ethnic Origin;Ethnic Population;Factor Analysis;fasting glucose;follow-up;Genes;Genetic;genome wide association study;genome-wide;Genomic DNA;Health;high risk;Hispanic;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;Individual;individualized prevention;insight;Insulin Resistance;Intervention;Latino;Latino Population;Life Cycle Stages;Life Style;lifestyle factors;lifetime risk;Longitudinal cohort;Maps;Mediator;men;Meta-Analysis;Methylation;methylation pattern;methylome;Mexican;Minority Groups;Modeling;Modification;Molecular;Multivariate Analysis;Names;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;Participant;Pathology;Pathway interactions;Pattern;peripheral blood;personalized intervention;Persons;Population Heterogeneity;prognostic;prospective;protective factors;psychosocial;Psychosocial Factor;Puerto Rican;pyrosequencing;Random Allocation;resilience;resilience factor;response;Risk;Risk Factors;Sampling;Skin;social culture;Social Environment;sociocultural determinant;socioenvironmental factor;South American;Subgroup;Survival Analysis;Validation;Woman;Work

PROJECT_TITLE: Sociocultural factors, DNA methylation and Risk of Diabetes in Hispanics/Latinos


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Opioids;Substance Misuse

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE The proposed research is responsive to RFA-DA-22-040 “High Priority HIV and Substance Use Research” and is relevant to public health because it will apply cutting-edge technologies to identify, isolate and characterize latently infected cells from people living with HIV who use opioids, with the goal of advancing new HIV-directed cure strategies. This project supports the NIH’s mission and aligns with one of its high-priority topics of research that awards AIDS-designated funds to support research toward a cure for HIV.

PI_NAMEs: ABATE, ADAM R.;CLARK, IAIN ;MURTHY, NIREN ;OTT, MELANIE MARIA (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Affect;antiretroviral therapy;Award;beneficiary;Binding;Biochemical;Biological Assay;Biology;Brain;Caring;CD4 Positive T Lymphocytes;Cell Surface Proteins;Cell Survival;Cells;Characteristics;Chemistry;Clinical;clinical care;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;cold temperature;CRISPR-mediated transcriptional activation;Data;Defective Viruses;Detection;Development;differential expression;DNA;DNA analysis;DNA Fragmentation;Drug usage;Drug user;Engineering;Equipment;experimental study;Failure;fluorescence activated cell sorter device;Funding;G Protein-Coupled Receptor Signaling;Gene Expression;Gene Expression Profile;Generations;Genes;genome sequencing;Genomics;Gifts;Goals;Heroin;Heroin Users;HIV;HIV Genome;induced pluripotent stem cell;Infection;insight;Intake;integration site;Investigation;Knowledge;Lymphoid;Lymphoid Cell;Maintenance;Measurement;Medical;medical vulnerability;memory CD4 T lymphocyte;Methods;Microfluidics;Microglia;Mission;Molecular;Morphine;multimodality;multiple omics;Myelogenous;Myeloid Cells;Nature;new technology;Opioid;opioid use;opioid user;Participant;Pathway interactions;personalized approach;Persons;prevent;Process;Property;Protein Analysis;protein expression;Proteins;proteogenomics;proteomic signature;Proteomics;Proviruses;Public Health;Publishing;Research;Research Support;RNA analysis;RNA Sequences;Role;social vulnerability;Sorting;Spleen;substance use;System;T-Lymphocyte;Technology;Testing;Tissues;transcriptional reprogramming;transcriptomics;translational approach;United States National Institutes of Health;Viral reservoir;Vulnerable Populations

PROJECT_TITLE: Sorting and Sequencing Latent Reservoirs in HIV+ Opioid Users


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Spinal Muscular Atrophy;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project narrative Our proposed studies are aimed to understand the functional consequences of pathogenic mutations in GEMIN5 in motor neuron degeneration and examine the biological pathways that are perturbed in patient iPSC neurons.

PI_NAMEs: PANDEY, UDAI B (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Affect;Age of Onset;Alternative Splicing;Animals;Applications Grants;Ataxia;Atrophic;autosome;Behavior;Biochemical;Biogenesis;Biological;Biological Assay;Biological Models;Brain;Cells;Cerebellar Ataxia;Clinical;clinically relevant;Coenzyme Q10;Complex;CRISPR/Cas technology;Defect;Developmental Delay Disorders;Disease;disease-causing mutation;DNA;Drosophila genus;Family;Fibroblasts;fly;Foundations;GEMIN5 gene;Genetic;genetic variant;Guide RNA;Heterozygote;Homologous Gene;Human;human disease;In Vitro;in vivo;Individual;Induced pluripotent stem cell derived neurons;Infant;Intervention;knock-down;Lead;life span;Light;loss of function;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Morphology;Motor;motor disorder;motor neuron degeneration;Motor Neuron Disease;Motor Neurons;mouse model;mRNA Precursor;Mus;mutant;Mutation;Neurologic;Neurons;novel;Pathogenesis;Pathogenicity;Pathway interactions;patient derived induced pluripotent stem cells;Patients;pharmacologic;Physiological;polysome profiling;premature;Process;protein complex;protein expression;protein function;protein protein interaction;Proteins;Proteomics;Reporting;Respiration;Rigor Mortis;RNA Splicing;RNA-Binding Proteins;Role;Small Nuclear Ribonucleoproteins;SMN protein (spinal muscular atrophy);SMN1 gene;snRNP Structural Core Protein;Spinal Muscular Atrophy;Spliceosomes;Symptoms;Syndrome;Testing;Time;Transcript;transcriptome sequencing;Transgenic Mice;Transgenic Model;Translations;translatome;Variant

PROJECT_TITLE: Identifying the molecular mechanisms of GEMIN5 mutations in a novel cerebellar ataxia syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-T(90)S]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Pediatric;Prevention;Rare Diseases;Tuberculosis

PHR: PROJECT NARRATIVE Tuberculosis (TB) is a major cause of childhood mortality globally, and novel point-of-care tools are needed to support earlier diagnosis and rapid TB treatment initiation in lower-level health facilities. This study will develop and initially validate artificial-intelligence (AI) models that utilize lung sounds to automatically detect lower airway abnormalities and TB in children, alone and in combination with clinical data included in TB treatment decision algorithms. If successful, this would support the integration of AI-based digital health tools into clinical care to increase the early detection and treatment of TB and other respiratory diseases in children.

PI_NAMEs: JAGANATH, DEVAN  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: 10 year old;5 year old;Address;Adult;Airway Disease;Algorithms;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;Cessation of life;Chest;Child;Childhood;Classification;Clinical;clinical care;Clinical Data;clinical diagnosis;cohort;Consensus;Data;deep learning model;Detection;Diagnosis;Diagnostics Research;digital;digital health;Disease;early childhood;Early Diagnosis;Early treatment;Enrollment;Evaluation;experience;Funding;Gambia;girls;Health care facility;HIV;improved;Infrastructure;laboratory facility;Lower respiratory tract structure;lung development;machine learning model;Modeling;mortality;novel;Performance;Physicians;Pilot Projects;Pneumonia;point of care;prevent;prospective;Pulmonary Tuberculosis;radiological imaging;radiologist;Radiology Specialty;Reader;Resource-limited setting;respiratory;Respiratory Disease;Respiratory Sounds;Respiratory Tract Diseases;Risk Factors;Role;Sensitivity and Specificity;Services;Signs and Symptoms;Site;South Africa;Specificity;Specimen;Sputum;Standardization;Stethoscopes;Subgroup;Symptoms;Testing;Thoracic Radiography;Time;tool;Training;Triage;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;tuberculosis treatment;Uganda;Underweight;United States National Institutes of Health;wireless;Work;World Health Organization

PROJECT_TITLE: Automated lung sound analysis to improve the clinical diagnosis of pulmonary tuberculosis in children

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Children with asthma from historically marginalized populations experience high rates of emergency department (ED) visits, and numerous barriers to guideline-based preventive asthma care in both clinical and home settings put these children at risk for needing additional ED or hospital care in the future. This project is expected to have a profound impact on public health because it proposes an innovative and technologically-driven intervention to address essential gaps in asthma care for children in the ED at greatest risk for poor outcomes. Should this program prove successful in improving preventive care and patient-important outcomes following ED discharge, it has the potential to serve as a sustainable model for children with asthma in other care settings, as well as for children with other chronic diseases that require well-informed home management to improve health.

PI_NAMEs: FREY, SEAN MICHAEL (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Absenteeism;Accident and Emergency department;Acute;acute care;Address;Adherence;Admission activity;Age;Anti-Inflammatory Agents;Asthma;Black race;care systems;Caregivers;Caring;Child;Child Care;Child Support;Childhood;Chronic Disease;Clinical;clinical outcome assessment;Color;Computerized Medical Record;Control Groups;cost;Data;Dedications;Diagnosis;Disparity;disparity reduction;Drug Prescriptions;Education;Educational process of instructing;Effectiveness;effectiveness evaluation;Elements;Emergency Care;Emergency department visit;Emergency Situation;enhanced care;Enrollment;experience;Flare;flexibility;follow up assessment;follow-up;functional outcomes;Future;Guidelines;Health;health care service;Health education;health literacy;Health Promotion;Healthcare Systems;Home;Home visitation;hospital care;Hospitalization;Hospitalized Child;Hospitals;implementation facilitators;implementation intervention;improved;innovation;Inpatients;Interruption;Intervention;intervention program;Label;Link;Low income;marginalized population;medication compliance;Modeling;Morbidity - disease rate;National Heart, Lung, and Blood Institute;novel;Outcome;Outpatients;Participant;Patient Compliance;patient home care;patient oriented;Patients;pediatric emergency;Pharmaceutical Preparations;pilot test;Population;Practice Management;Prevention;Preventive;Preventive care;Preventive therapy;Preventive treatment;Primary Care;primary care provider;Process;Program Effectiveness;programs;Provider;Psychological reinforcement;Public Health;Quality of life;randomized trial;Recommendation;reduce symptoms;Regimen;response;Risk;Risk Factors;Schools;Self Management;Severities;Shapes;Symptoms;Techniques;Technology;telehealth;Telemedicine;Telephone;Testing;Time;tool;treatment optimization;treatment planning;virtual;virtual visit;Visit;Work

PROJECT_TITLE: Telehealth-Enhanced Asthma Care for Home after the Emergency Room (TEACH-ER)

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_DEPT: PHARMACOLOGY

PHR: NARRATIVE This project aims at developing microscopy and computational platforms for the analysis of mammalian cell libraries with endogenously tagged proteins. These new tools will enable proteome-wide analysis of protein localization and interaction networks in a native cellular context.

PI_NAMEs: HUANG, BO  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Adoption;cell behavior;Cell Cycle;Cell Line;Cell Physiology;Cells;Cellular biology;cellular engineering;cellular imaging;Collaborations;Collection;computational platform;Computer software;confocal imaging;Confocal Microscopy;CRISPR/Cas technology;Cytoplasmic Granules;Data;Data Set;denoising;design;Development;Exhibits;experimental study;Fluorescence;Fostering;Funding;Generations;Genes;Genomics;Goals;Heterogeneity;Human Cell Line;Human Genome;Image;image processing;imaging platform;Immunoprecipitation;improved;instrument;Integration Host Factors;interest;Java;Learning;Libraries;Light;Lighting;live cell microscopy;Mammalian Cell;Maps;Mass Spectrum Analysis;Measurement;Microscope;Microscopy;movie;nanobodies;Optics;Output;Pathologic;Performance;Phase;Photobleaching;Phototoxicity;Physics;Process;Production;Protein Analysis;protein complex;protein distribution;Protein Dynamics;Proteins;Proteome;Proteomics;Pythons;real-time images;Regulation;Resolution;Role;screening;Shapes;Signal Transduction;spatiotemporal;System;Techniques;technology platform;Time;tool;transfer learning;usability;Virus Diseases

PROJECT_TITLE: Mapping endogenous protein dynamics in living cells

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: Sherborn

ORG_NAME: LUCIOLE PHARMACEUTICALS, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is a very serious, incurable disease of the brain, which is a common cause of death throughout the world. By targeting a novel therapeutic target, Luciole Pharmaceuticals is developing first-in-class agents as disease-modifying therapeutics for AD. Our efforts have the potential to lead to the discovery of a novel, safe, and very effective oral medicine for AD, which will improve patients’ quality-of-life and increase their life expectancy.

PI_NAMEs: RUMSEY, WILLIAM L (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: Acetylcholinesterase;Adult;Affect;age-related disease;Allosteric Site;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Amyloid;APP-PS1;Base Excision Repairs;Binding;Bioenergetics;Biological;Biological Assay;Biological Markers;blood-brain barrier penetration;Brain;Brain Diseases;candidate selection;Cause of Death;Cell Death;Cell Death Induction;Cell Nucleus;Cell Survival;Cells;Cessation of life;Chemistry;Chronic;Circulation;Clinical;clinical candidate;Cognition;Cognitive deficits;cognitive function;Collaborations;cost effective;Deacetylation;Dementia;Development;Disease;disease model;Disease Progression;DNA;DNA glycosylase;DNA lesion;DNA Repair;Down-Regulation;drug modification;economic cost;enzyme pathway;Excision;Exercise;Failure;Genetic Polymorphism;Guanine;HDAC1 gene;Histone Deacetylase;Human;improved;In Vitro;in vivo;in vivo evaluation;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Inflammation;Inflammatory;Lead;Lesion;Libraries;Life Expectancy;Locomotion;loss of function;Machine Learning;Marketing;Measurement;Mediating;Medicine;member;Memory impairment;Metabolic;meter;Mexican Americans;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Monitor;Motion;mouse model;Mus;mutant mouse model;N-Methyl-D-Aspartate Receptors;Neurons;neuroprotection;new therapeutic target;next generation;novel;novel therapeutic intervention;OGG1 gene;Oral;Oral Medicine;overexpression;oxidation;oxidative damage;Oxidative Stress;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacologic Substance;Phase;Plasma;pre-clinical;precision drugs;preclinical development;Prefrontal Cortex;preservation;prevent;Property;Proteins;Publications;Publishing;Quality Control;Quality of life;Reaction;Reactive Oxygen Species;recruit;reduce symptoms;repaired;research clinical testing;Respiration;Respiratory Chain;response;Safety;safety assessment;screening;Small Business Innovation Research Grant;small molecule;socioeconomics;standard of care;Structure;success;targeted treatment;tau Proteins;Testing;Toxin;transcriptome;transcriptomics;Zebrafish

PROJECT_TITLE: Discovery and development of OGG1 activators as precision drugs for modification of Alzheimer's disease progression.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-P(11)]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative The progressive accumulation of DNA mutations in somatic tissues drives cancer and other diseases; despite significant advances in our understanding of mutational processes, the answer to many fundamental questions in the field of genome integrity is still a mystery. In this project, the first goal is to develop a novel functional ‘reporter’ to estimate DNA mutation rates in mammalian cells with a sensitivity >50 fold compared to current methods. The second major goal of this project will be to study mutation rate in several types of human cells and comprehensively identify all genes that regulate mutation rates across cell types.

PI_NAMEs: BOEKE, JEF D;DAVOLI, TERESA  (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Binding;Biological Assay;carcinogenesis;Carcinogens;Cell Line;cell type;Cells;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Communities;Data;design;Disease;DNA cassette;DNA Damage;DNA Repair;DNA Sequence Alteration;Event;experimental study;Exposure to;Family;follow-up;Frequencies;gain of function;Genes;Genetic;genetic approach;Genetic Determinism;Genetic Markers;Genetic Screening;Genetic study;Genome;genome integrity;Genome Stability;genome-wide;Germ-Line Mutation;Goals;Guide RNA;HCT116 Cells;Health;Human;Human body;human disease;human tissue;Individual;Induced Mutation;innovation;Knowledge;Laboratories;Lead;Left;Libraries;Location;loss of function;loss of function mutation;Malignant Neoplasms;Mammalian Cell;Methodology;Methods;Mismatch Repair;model organism;Mutagenesis;Mutagens;mutant;Mutate;Mutation;Mutation Detection;novel;Open Reading Frames;overexpression;Pathway interactions;Pharmaceutical Preparations;Point Mutation;Process;promoter;Proteins;prototype;Reporter;Repression;Resistance;screening;sensor;Shapes;Signal Transduction;Single Nucleotide Polymorphism;Site;Sorting;System;Testing;Time;Tissues;tool;Variant;variant detection;Writing;Yeasts

PROJECT_TITLE: MutSensor System: A Set of Highly Sensitive Mutation Reporters to Dissect Genome Stability in Health and Disease

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]