NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The research proposed here will systematically quantify the effects of craniofacial transcription factor dosage changes on molecular, cellular, and morphological phenotypes. This work will provide: (1) mechanisms underlying sensitivity to transcription factor dosage in normal-range and disease-associated variation, (2) insights into the specific facial phenotypes observed in a range of craniofacial syndromes, and (3) basic insights into the mechanisms of transcription-factor mediated regulation. Finally, by driving forward our understanding of craniofacial variation and disease, the proposed research will nominate key genes and pathways that one day could inform disease prediction and/or therapeutic development.

PI_NAMEs: NAQVI, SAHIN  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Advisory Committees;Alleles;ATAC-seq;Automobile Driving;Binding;Biological;Biological Assay;brain shape;Buffers;career;career development;cell motility;Cephalic;Characteristics;Chemicals;Chromatin;Cleft Palate;Communities;Complex;Congenital Abnormality;craniofacial;craniofacial development;craniofacial disorder;Data;Data Set;deep learning;Defect;Development;Developmental Gene;Developmental Process;Disease;disorder risk;dosage;Dose;Educational workshop;embryo cell;Ensure;Environment;experience;Face;Faculty;Feedback;functional genomics;Gene Dosage;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Genetic;Genetic study;Genetic Transcription;genetic variant;genome editing;genome wide association study;genome-wide;Goals;Grant;Human;human embryonic stem cell;Human Genetics;In Vitro;Individual;insight;Jaw;knock-down;Knock-out;Learning;Machine Learning;Mandible;Maps;Measurement;Mediating;Mentors;model building;Modeling;Molecular;Morphology;mouse genetics;MSX1 gene;Mutation;Nature;Neural Crest Cell;Normal Range;novel;Occupations;Pathway interactions;PAX3 gene;Phase;Phenotype;Pierre Robin Syndrome;Play;Population;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;predictive modeling;progenitor;programs;Proliferating;Proteins;Publications;Publishing;Rare Diseases;rare variant;Regulation;Regulator Genes;Regulatory Element;Reporter;Research;Resources;response;risk prediction;Role;Skeleton;skills;student mentoring;success;symposium;Syndrome;System;Systems Biology;Testing;TFAP2B gene;therapeutic candidate;therapeutic development;tool;Training;trait;transcription factor;Transcriptional Regulation;transcriptome sequencing;Translating;TWIST1 gene;Untranslated RNA;Variant;Work;Writing

PROJECT_TITLE: Mapping and prediction of quantitative transcription factor dosage effects to understand variation in craniofacial morphology and disease

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: BRONX

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Intellectual disability (ID) disorders lead to difficulties in the educational, social, and financial realms for those affected and their caregivers. Defective neuronal translation is common theme found in ID, neurodevelopmental, and neurodegenerative disorders. Using a combination of genome wide approaches, we will characterize the effects of ID-associated mutations on a class of histone modifying proteins essential for translation in neurons.

PI_NAMEs: YHESKEL, MATANEL  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Ablation;Address;Adult;Affect;Age;Binding;Biological Assay;Biology;Biotin;Brain;Caregivers;chromatin immunoprecipitation;chromatin modification;Cleavage Under Targets and Release Using Nuclease;clinically relevant;Cognition;Cognitive;cognitive function;Consensus Sequence;Data;Defect;demethylation;Desire for food;Development;Disease;DNA;Down-Regulation;Drosophila genus;Drosophila melanogaster;Education;Epigenetic Process;exome sequencing;fly;Gene Expression;Gene Proteins;Genes;Genetic Transcription;genome-wide;histone demethylase;histone modification;Histones;Human;Impaired cognition;improved;in vivo;Individual;insight;Intellectual functioning disability;knock-down;Knockout Mice;Label;Lead;Learning;Link;long term memory;loss of function;Lysine;Maintenance;Mass Spectrum Analysis;Memory;Methylation;Modeling;Molecular;mutant;Mutation;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuron development;Neurons;Orthologous Gene;paralogous gene;Pathway interactions;Patients;Phenotype;Population;Process;promoter;Protein Family;protein protein interaction;Proteins;Publishing;Puromycin;Radial;recruit;Ribosomal Proteins;Role;social;Testing;Therapeutic;therapeutic target;Tissues;transcriptome sequencing;Translations;X-linked intellectual disability

PROJECT_TITLE: Epigenetic and transcriptional consequences of Intellectual Disability-associated mutations in the histone lysine demethylase KDM5.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative Alzheimer’s Disease (AD) is characterized by progressive breakdown in the circadian system, which regulates 24-h cycles in a number of homeostatic processes such as sleep, hormone release, and immune function. The immune system is critically regulated by the circadian system and trafficking of immune cells into the central nervous system is an understudied area implicated in regulating AD. Here we propose to determine circadian regulation of the brain-immune interface, how dysregulation of circadian rhythms contributes to AD-pathology, and whether strategies to boost circadian rhythms protect against brain aging and AD, with the goal of unveiling novel, translationally-relevant insights into the mechanisms mediating AD.

PI_NAMEs: FONKEN, LAURA K (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: 3xTg-AD mouse;Address;Affect;Age;age related decline;aged;Aging;aging brain;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;American;Anti-Inflammatory Agents;Area;ARNTL gene;Arrhythmia;Behavior;Behavioral;Behavioral Symptoms;Biological Process;Biological Rhythm;Brain;Cell Adhesion;cell motility;Cells;Central Nervous System;Choroid Plexus Epithelium;circadian;circadian biology;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;clinical diagnosis;Cognition;Cognitive;cognitive change;cognitive function;Darkness;Dementia;Dependence;Deterioration;Development;disability;Disease;Disease Progression;Early Intervention;effective therapy;Equilibrium;experience;experimental study;Gene Expression;Genetic;Goals;Homeostasis;Hormones;human old age (65+);Immune;immune activation;immune function;Immune system;Immunity;Immunology;immunoregulation;Immunotherapy;Impaired cognition;improved;in vivo;Individual;Inflammation;Inflammatory;inflammatory modulation;innovation;insight;Investigation;Knock-out;Leukocyte Trafficking;Leukocytes;Light;lymphatic vasculature;Mediating;Meningeal;Meninges;Microglia;migration;molecular clock;Mus;Nervous System Physiology;Neurobehavioral Manifestations;Neuroimmune;neuroinflammation;neuropathology;Neurosciences;new therapeutic target;Newly Diagnosed;novel;novel strategies;novel therapeutics;old mice;Organ;Pathologic;Pathology;Patients;Periodicity;Peripheral;Persons;pharmacologic;Phase;Phenotype;Physiological Processes;Population;potential biomarker;Prevalence;Process;Protocols documentation;Quality of life;receptor;Research;Role;Signal Transduction;Sleep;Sleep disturbances;Sleep Wake Cycle;Structure of choroid plexus;success;System;T-Lymphocyte;Testing;Therapeutic;Time-restricted feeding;Tissues;trafficking

PROJECT_TITLE: Disrupted Circadian Regulation of Cell Migration at CNS-Immune Interfaces in Aging and Alzheimer's Disease


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Complementary and Integrative Health;Dementia;Headaches;Migraine;Neurodegenerative;Neurosciences;Pain Research;Sleep Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BERKELEY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative  While it is well documented that some individuals show vulnerability to cognitive decline with advancing age, the mechanisms that lead to this decline are unknown, and no interventions to rescue brain function in aging individuals exist to date. The proposed studies explore the association between aging-related degradation of circadian rhythms, blood-brain barrier function and neuroinflammation as potential culprits to vulnerability to cognitive decline. We apply a novel lighting treatment we developed that rescues degrading circadian rhythms to recover cognitive functioning and brain health.

PI_NAMEs: KAUFER, DANIELA ;KRIEGSFELD, LANCE J (contact)

PROJECT_TERMS: age related;age related decline;Age-associated memory impairment;aged;Aging;aging brain;aging related;Albumins;Alzheimer's disease model;Amyloid beta-Protein;animal old age;Animals;Astrocytes;Behavior;Behavioral;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Tests;blood-brain barrier function;blood-brain barrier permeabilization;Brain;brain dysfunction;brain health;Cells;Characteristics;circadian;circadian pacemaker;Circadian Rhythms;Cognition;Cognitive;cognitive enhancement;cognitive function;cognitive task;Collaborations;Color;Coupling;Data;Dementia;Denmark;Deterioration;Diagnosis;Disease;Disease Progression;Elderly;Endothelial Cells;Endothelium;Exhibits;Fatigue;Frequencies;Gene Expression;Human;Impaired cognition;improved;Individual;Individual Differences;Infiltration;inhibitory neuron;Intervention;juvenile animal;Lead;life span;Light;Lighting;Link;loss of function;Masks;Measures;Mediator;middle age;Migraine;mouse model;Mus;Nerve Degeneration;neuroinflammation;neuropathology;Neuropeptides;neuroprotection;novel;novel therapeutics;Patients;Persons;Phase;Phototherapy;prevent;Psyche structure;Receptor Signaling;Research Personnel;resilience;Resistance;Rodent;Serum Proteins;Signal Transduction;Sleep;Sleep disturbances;suprachiasmatic nucleus;Symptoms;System;tau Proteins;Technology;Testing;Tight Junctions;Tissues;tool;transcytosis;Transforming Growth Factor beta;Universities;virtual;Vulnerable Populations;Work

PROJECT_TITLE: Non-invasive lighting treatment as a novel therapeutic for age-related cognitive decline

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-B(02)M]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Data Science;Dementia;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: INDIANAPOLIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative  The proposed research aims to develop novel statistical methodologies for longitudinal integrated mechanistic modeling of multiview data, including environmental, *omics, imaging, and neurocognitive data. The proposed methodologies, developed and applied to alcohol & neurodevelopmental and Alzheimer's disease research, are expected to elucidate longitudinal variations in brain structure and function, to characterize population hetero- geneity, to enhance understanding of disease pathology, to help identify biomarkers, and to provide guidance on personalized early prevention/intervention strategies to promote well-being in adolescent and elderly popula- tion. Therefore, the proposed research will seek fundamental knowledge in integrated analysis for improving our understanding of neurodevelopmental/neurodegenerative trajectories and related mental disorders.

PI_NAMEs: ZHAO, YI  (contact)

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: Address;Adolescent;Aging;Alcohols;Algorithms;Alzheimer's Disease;Alzheimer's disease pathology;Area;Articulation;Behavior;behavior measurement;Behavioral;Big Data;biomarker identification;Brain;Characteristics;Clinical Investigator;Clinical Sciences;Collaborations;Complex;complex data;Complex Variables;Computational algorithm;Computer software;connectome;Data;Data Analyses;Data Element;data integration;data modeling;data structure;Development;Disease;disease heterogeneity;Disease Progression;Elderly;Equation;Fostering;Functional Imaging;Genetic;Goals;Growth;Heterogeneity;heterogenous data;high dimensionality;Human;Image;improved;Individual;individualized prevention;innovation;insight;Intermediate Variables;Intervention;Investigation;Joints;Knowledge;large datasets;Literature;longitudinal analysis;Mathematics;Mental disorders;Methodology;Methods;Modality;Modeling;multidimensional data;Nerve Degeneration;network models;Neurocognitive;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;Neuropsychology;Neurosciences;novel;novel marker;open source;Outcome;Pathology;Pathway interactions;Pattern;Personal Satisfaction;personalized intervention;Phenotype;Population;Population Heterogeneity;precision medicine;Prevention;Reproducibility;Research;Risk Factors;Role;Series;sex;Sex Differences;Site;Source;statistical learning;Statistical Methods;Statistical Models;Structure;structured data;Substance abuse problem;Techniques;Time;Time Factors;trait;Variant;vector

PROJECT_TITLE: Statistical methods for longitudinal integrated mechanistic modeling of multiview data

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Tendon injuries are widespread and are challenging to treat due to limited regenerative capacity. This proposal will advance our understanding of an adult tendon progenitor cell population and define its regulation in homeostasis and repair. This knowledge could be used to better inform the development of therapies for human tendon injuries.

PI_NAMEs: GALLOWAY, JENNA L (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: achilles tendon;Adult;Affect;Behavior;beta catenin;Biological Assay;Biology;Birth;Cell Culture Techniques;Cell Differentiation process;cell injury;Cell Physiology;Cell Proliferation;Cell secretion;Cell surface;cell type;Cells;Characteristics;Clinical;Data;Defect;design;Development;Disease;Excision;fetal;Gene Expression;Gene Expression Profile;Genes;Genetic;Goals;healing;Homeostasis;Human;Impaired healing;improved;In Vitro;in vitro activity;in vivo;Individual;inducible Cre;Infiltration;Injury;Knowledge;Label;loss of function;Maintenance;Mediating;Modeling;Molecular;mouse genetics;Movement;Mus;Neonatal;next generation sequencing;novel strategies;novel therapeutics;Outcome;patellar tendon;Pathway interactions;Patients;Population;Porcupines;Production;progenitor;programs;Proliferating;Proteins;recruit;regeneration potential;Regenerative capacity;regenerative healing;Regenerative Medicine;Regulation;repaired;response;response to injury;Role;self-renewal;Signal Transduction;Site;stem;stem cell population;stem cells;Techniques;Tendon Injuries;Tendon structure;Testing;Therapeutic;therapy development;WNT Signaling Pathway

PROJECT_TITLE: Regulation of Axin2-expressing cells in the adult tendon

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Orphan Drug;Pediatric;Pediatric Cancer;Physical Activity;Prevention;Radiation Oncology;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE INST FOR BIOMEDICAL/CLINICAL RES

ORG_STATE: WA

PHR: PROJECT NARRATIVE Fatigue is one of the most prevalent and debilitating symptoms among male cancer survivors and has a negative impact on their quality of life. These patients also have a greater prevalence of testosterone deficiency compared with healthy age-matched controls. Pivotal trials of testosterone replacement therapy in non-cancer patient populations have shown an improvement in fatigue in men randomized to testosterone compared with placebo; however, the efficacy of testosterone replacement therapy on cancer-related fatigue has not been studied. This large randomized, double-blind, placebo-controlled trial will determine the efficacy of testosterone replacement on cancer-related fatigue in young male cancer survivors who report fatigue and have testosterone deficiency.

PI_NAMEs: BASARIA, SHEHZAD ;GARCIA, JOSE M. (contact)

PROGRAM_OFFICER_NAME: SMITH, ASHLEY

PROJECT_TERMS: active method;Affect;Age;Body Composition;Cancer Patient;Cancer Survivor;cancer therapy;Cardiovascular system;chemotherapy;Chemotherapy and/or radiation;Clinic;Clinical;comparative efficacy;Cranial Irradiation;Data;debilitating symptom;Decreased Libido;Diagnosis;Disease remission;Double-Blind Method;double-blind placebo controlled trial;efficacy evaluation;Erectile dysfunction;Exhibits;experience;Fatigue;Fatty acid glycerol esters;Goals;High Prevalence;improved;Individual;Injections;lean body mass;Longevity;male;Malignant Neoplasms;Measurement;member;men;Moods;muscle strength;older men;Outcome;Patient Outcomes Assessments;patient population;Patients;Pelvis;Personal Satisfaction;Phenotype;Physical activity;Pilot Projects;Pituitary Gland;Placebo Control;Placebos;population based;Prevalence;primary outcome;Prior Chemotherapy;Productivity;Prostate;Quality of life;Radiation therapy;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Recording of previous events;reduce symptoms;reduced muscle strength;Reference Values;Reporting;Research;Role;Safety;Sex Behavior;Sex Functioning;Sexual Dysfunction;side effect;Supervision;Symptoms;Testosterone;testosterone replacement therapy;Therapeutic;United States;young cancer survivor;young man

PROJECT_TITLE: Improving Patient-Important Outcomes with Testosterone Replacement in Hypogonadal Men with a Prior History of Cancer

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Congenital Structural Anomalies;Gene Therapy;Genetics;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROSURGERY

PHR: Our ability to study the brain during development, aging, how it changes through learning, or during disease progression is fundamentally enhanced through our ability to make genetic constructs and viral products for genetic manipulation of neuronal circuits and to carry out functional and behavioral validation in the whole animal, tissue slices or culture systems followed by in vivo or post-mortem imaging. The Stanford Neuroscience Research Center (SNRC) for Human Brain Organogenesis (HBOP), Behavior (BFNL), Gene Vectors (GVVC), and Microscopy (NMS) was created to meet these needs. Here we aim to centralize and disseminate these fundamental tools and techniques with annual workshops and 6 annual integrated free of charge pilot studies for merit-based selected projects for external laboratories from the national neuroscience community.

PI_NAMEs: NEWSOME, WILLIAM T;PASCA, SERGIU ;SHAMLOO, MEHRDAD  (contact);WANG, GORDON X

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TERMS: 3-Dimensional;Acceleration;Aging;Animals;Area;Array tomography;Autopsy;base;Basic Science;Behavior;behavior test;Behavioral;Behavioral Model;behavioral phenotyping;behavioral study;Biological Assay;Biotechnology;Brain;Brain Diseases;Brain region;brain tissue;Cell Communication;Cell Line;Cell model;Cells;Central Nervous System Diseases;Charge;Clinical;Clinical Research;clinically relevant;cloud based;Collaborations;Communities;Complementary DNA;Complex;computerized data processing;Country;Custom;Development;disease model;Disease Progression;drug candidate;Educational process of instructing;Educational workshop;efficacy study;Emerging Technologies;Evaluation;experimental study;functional outcomes;Funding;Generations;Genes;Genetic;genetic manipulation;Genetic Models;Genomics;Goals;Grant;hands on instruction;Human;human pluripotent stem cell;Image;Image Analysis;imaging system;Imaging Techniques;Imaging technology;improved;in vitro Model;in vivo;Individual;Industry Standard;innovation;innovative technologies;Institution;International;Investigation;Investments;knock-down;Laboratories;Learning;Longitudinal Studies;Maintenance;member;Memory;Methods;Microscopy;Mission;Missouri;Modality;Modeling;Molecular;molecular dynamics;Mus;Nervous System;Neurodegenerative Disorders;neuroimaging;neuronal circuitry;Neurosciences;Neurosciences Research;new technology;novel;novel strategies;novel therapeutics;Opiate Addiction;optogenetics;Organogenesis;Organoids;outreach;Participant;Pathology;Peer Review;Pennsylvania;Persons;Phenotype;Pilot Projects;Plasmids;Preparation;Production;programs;Proteomics;Publications;Reagent;Recombinant Proteins;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Resources;Rodent;Running;Scholarship;Scientist;self organization;Services;sharing platform;Signal Transduction;Site;Slice;social;Standardization;Stem Cell Research;Stroke;System;Tauopathies;Techniques;Technology;Testing;Texas;three dimensional cell culture;three dimensional structure;Three-Dimensional Imaging;Time;Tissues;tool;Touch sensation;Training;Transgenic Organisms;Translational Research;Transplantation;underrepresented minority student;United States National Institutes of Health;Universities;Validation;vector;Viral;viral gene delivery;Viral Vector;Virus;Vision;Visualization;web site;Work

PROJECT_TITLE: A Shared Neuroscience Platform for National Dissemination and Training  in Brain Organogenesis, Behavioral and Brain Disease Models, Viral Vectors, and Imaging Technologies


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: DURHAM

ORG_NAME: CELL MICROSYSTEMS, INC.

ORG_STATE: NC

PHR: Project Narrative  Targeted monoclonal antibodies have become essential for use as both life science tools and as clinical therapeutics. Although there are currently several methods for producing antibodies, including hybridomas and in vitro immune display libraries, the process is laborious, costly, and inefficient. Screening these antibody libraries requires iterative rounds of affinity screening and cloning without functional validation, which is typically post-screening against a limited number of antibody clones. To improve the efficiency of this process, we propose this Phase II study using a fully automated method for functionally screening hundreds of thousands of primary B-cells from immunized animals on the high throughput CellRaft-HTS array and automated CellRaft AIR® System. The CellRaft Technology allows imaging-based sorting and isolation of single cells and clones, thereby allowing sophisticated phenotypic characterization to be incorporated into antibody discovery screening workflows.

PI_NAMEs: HARTMAN, JESSICA  (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: Affinity;Animals;Antibodies;Antibody Formation;antibody libraries;Antibody-Producing Cells;Antigen Targeting;Antigens;Automation;B-Lymphocytes;Binding;Binding Proteins;Biological Assay;Biological Products;Biological Sciences;Cell Culture Techniques;Cell Line;Cell Separation;Cells;cellular imaging;Clinical;Cloning;Coculture Techniques;commercialization;Computer software;cost;cost effective;cost efficient;Cost Savings;Cytometry;Data;Development;Diagnostic tests;Egg Proteins;Epidermal Growth Factor Receptor;ERBB2 gene;Floor;Fluorescence;Generations;Goals;GPC3 gene;Growth;Harvest;high throughput screening;Hybridomas;Image;imaging capabilities;Immune;Immunize;improved;In Vitro;in vitro testing;in vivo;Individual;Industrialization;Industry;Laboratories;lead candidate;Libraries;Licensing;manufacture;Marketing;Medicine;Methods;Modern Medicine;Monitor;Monoclonal Antibodies;Mus;novel;nuclear factors of activated T-cells;Phase;phase 1 study;phase 2 study;Phenotype;Polystyrenes;Process;Production;programs;Proteins;Reagent;Recovery;Reporter;Research;screening;Screening procedure;Series;Signal Transduction;Site;Sorting;Splenocyte;success;System;Techniques;Technology;Testing;Therapeutic;Therapeutic Monoclonal Antibodies;Time;tool;Tumor Antigens;Universities;Vaccinated;Vaccination;Validation;Work

PROJECT_TITLE: Rapid identification and selection of functional antigen-specific monoclonalantibodies by FcGR-enabled screening on CellRaft Arrays in the CellRaft AIRSystem


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: ALACHUA

ORG_NAME: FOUNDATION FOR APPLIED MOLECULAR EVOLUTN

ORG_STATE: FL

PHR: NARRATIVE  The NIGMS has asked for plans to create new tools and technologies that will allow researchers to ask new questions, questions that they might not even think of asking without these tools. We provide such a plan here, to deliver a technology platform that will create molecules that covalently modify, tag, and destroy protein targets that are chosen by researchers and clinicians to solve scientific, diagnostics, and disease management problem. This platform has been sought without success for over 40 years, because it can be applied to every area of medical research, diagnostics, and disease treatment. As just four examples, modification may attach a payload to the protein, allowing it to be internalized to cancer cells. It may fluorescently tag cancer cells to guide a surgeon cutting out a tumor. Its tagging capabilities will help neurobiologists map the brain. For researchers, modifying the targeted protein, researchers will test hypotheses about the role of that protein in biology, both natural and diseased.

PI_NAMEs: BENNER, STEVEN A (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: 2019-nCoV;Acceleration;acyl group;Acylation;Address;Amides;Amino Acid Sequence;amino group;Antibodies;Area;Binding;Binding Proteins;Bioinformatics;Biological;biological systems;Biology;Biomedical Research;Brain Mapping;cancer cell;Catalytic Antibodies;Catalytic RNA;cell killing;Cell surface;Cells;Chemicals;Chemistry;Clinical Laboratory Information Systems;combinatorial chemistry;Coronavirus;COVID-19 detection;COVID-19 pandemic;Data;design;Development;Diagnostic;Disease;Disease Management;DNA;DNA biosynthesis;DNA sequencing;Doxorubicin;drug discovery;Enzymes;Esters;Evolution;Feedback;gene synthesis;genetic information;GPC3 gene;Image;In Vitro;in vivo;India;Information Systems;innovation;invention;Knowledge;Laboratories;Language;Licensing;Lysine;Malignant neoplasm of liver;Measures;Medical;Medical Research;Medicine;meetings;Modification;molecular recognition;multiplex diagnostics;National Institute of General Medical Sciences;new technology;next generation sequencing;Organic Chemistry;Outcome;Peptides;Performance;Pharmaceutical Preparations;Physiological;Process;Protein Engineering;protein function;Protein Sequence Analysis;Proteins;Reaction;Reaction Time;Reagent;Reproducibility;Research Personnel;Resected;Rest;Ribosomal RNA;Role;Science;Ships;Site;Sodium Chloride;Specificity;success;Surgeon;Synthesis Chemistry;synthetic biology;System;Technology;technology platform;Temperature;Testing;Thermodynamics;tool;Toxin;Translating;tumor;Vision;web-based tool;Work

PROJECT_TITLE: Easily Used Kits to Evolve Reagents that Covalently Tag and Inactivate Proteins

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Overall—Project Narrative  Our proposed renewal, the Health, Aging and Dementia in South Africa: A Longitudinal Study (HAALSI) Program, aims to assess the biological, social, and economic factors and public policies that interact to influence the course of dementia and cognitive decline among older adults in South Africa, as well as major diseases and disorders (cardiometabolic disease and HIV) that impact cognitive function. We build upon our existing HAALSI cohort of older adults embedded within the well-characterized Health and Demographic Surveillance System (HDSS) of Agincourt, South Africa, which will provide 13 years of in-depth follow-up, establish a new nationally representative cohort, and conduct detailed dementia assessments within subsamples of each cohort using the Harmonized Cognitive Assessment Protocol (HCAP). We seek to implement approaches to the study of dementia and other health and aging related disorders that are valid, reliable, and harmonized with global studies of dementia and aging, in a country where little research has been done on a population basis.

PI_NAMEs: BERKMAN, LISA F (contact);GAZIANO, THOMAS A

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Adopted;Adult;Africa;Age Years;Aging;aging population;aging related;aging related disease;Alzheimer's Disease;Behavioral;Biological;Biological Factors;Biological Markers;Cardiometabolic Disease;Chronic Disease;Clinical assessments;Cognition;cognitive function;cognitive performance;cognitive testing;cohort;Cohort Studies;Collaborations;Collection;Communities;Complex;Country;Data;Data Collection;Dementia;dementia burden;dementia risk;design;Development;Disabled Persons;Disease;Economic Factors;Economics;Ensure;Epidemiology;experience;Family;follow-up;Funding;Genetic Population Study;Health;Health and Retirement Study;Health Policy;healthy aging;HIV;HIV Infections;Household;human old age (65+);Impaired cognition;improved;Incidence;Income;Individual;innovation;insight;Interview;Longitudinal Studies;low and middle-income countries;Measures;member;men;Methods;Mission;mortality;neuroimaging;older adult;Outcome;Participant;Pattern;Personal Satisfaction;Persons;Physical Function;Policies;Population;Population Dynamics;Population Genetics;population health;Population Research;Prevalence;programs;Protocols documentation;Public Health;Public Policy;recruit;Research;Research Project Grants;resilience;response;Rest;Risk Factors;Rural;Rural Community;rural South Africa;salt intake;Sampling;Security;Shapes;Sister;social;social factors;social health determinants;Social Policies;socioeconomics;South Africa;Structure;Surveys;System;virtual;Woman


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative

PI_NAMEs: BERKMAN, LISA F (contact)

PROJECT_TERMS: Adherence;Adult;Advisory Committees;Africa;African;Aging;Body Composition;Cardiometabolic Disease;Cognition;Communication;Communities;data dissemination;Data Science;Dementia;digital;disorder risk;Ensure;Evaluation;Funding;Future;Genomics;Geography;Health;Health and Retirement Study;health disparity;Health Sciences;Heredity;Human;human subject protection;innovation;Institution;International;Leadership;Longitudinal Studies;Methodology;multiple chronic conditions;Network Infrastructure;Office of Administrative Management;Participant;Pathway interactions;population health;Population Research;Problem Solving;programs;Protocols documentation;Publications;Research;research data dissemination;Research Personnel;Research Project Grants;Scientist;Sister;Site;South Africa;South African;success;Supervision;System;Time;Visualization;Wit;Work

PROJECT_TITLE: Core A - Leadership and Administration Core


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: SANTA CRUZ

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: This research addresses the public health concern of metastatic breast cancer, a major cause of breast cancer related deaths in women and treatment is largely reliant on systemic therapies that have adverse side effects. This project will provide a detailed understanding of the cellular underpinning of metastatic cells and provide novel approaches for preventing or reducing metastatic burden. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to improving outcomes for patients with metastatic disease.

PI_NAMEs: SIKANDAR, SHAHEEN  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Address;Adhesions;Binding;Bioinformatics;Biological Assay;Blood Vessels;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;cancer cell;Cause of Death;Cell Adhesion Molecules;Cells;Cessation of life;cytokine;Data;design;Development;Disease;Distant;Endothelium;Foundations;Gene Expression;Genes;Genetic Transcription;Goals;Hematopoietic stem cells;Human;IL6 gene;improved outcome;In Vitro;in vivo;Inflammation;Inflammatory;innovation;insight;Interleukin-1 beta;knock-down;Knowledge;Link;LMO2 gene;Malignant Breast Neoplasm;Measures;Mediating;Metastasis Induction;Metastatic breast cancer;mimicry;Minority;Minority Groups;Mission;Modeling;Molecular;mouse model;multidisciplinary;Mus;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;novel therapeutic intervention;Oncogenes;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patient-Focused Outcomes;Patients;Phenotype;Phosphorylation;polyoma middle tumor antigen;Population;Population Heterogeneity;Positioning Attribute;prevent;Process;Proteins;Public Health;Recurrence;Research;Research Personnel;research study;response;Sampling;side effect;Signal Transduction;single-cell RNA sequencing;STAT3 gene;Systemic Therapy;T-Lymphocyte;Target Populations;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;TNF gene;transcription factor;Tube;tumor;tumor initiation;United States National Institutes of Health;Woman;Women's mortality

PROJECT_TITLE: Molecular mechanisms regulating LMO2+ metastasis initiating cells

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative

PI_NAMEs: ROHR, JULIA KATHERINE (contact)

PROJECT_TERMS: Address;Age Years;Aging;Autopsy;Biological Markers;Biometry;Cessation of life;Cognition;cohort;Collaborations;Collection;Communities;Complex;Computer Assisted;Data;Data Analyses;data cleaning;Data Collection;data management;Data Management Resources;Data Set;data sharing networks;Dementia;Developing Countries;Development;Ensure;Evaluation;experience;Feedback;Funding;Goals;Health;Health and Retirement Study;Human Resources;interest;International;Interview;Language;Linguistics;Location;Longitudinal Studies;Longitudinal Surveys;Maintenance;Measurement;Measures;member;men;Methods;Migrant;Monitor;older adult;Outcome;Personal Satisfaction;Population;Procedures;Process;programs;Protocols documentation;Public Health;Quality Control;Questionnaires;Reporting;Research;research and development;Research Personnel;response;Role;Sampling;Sister;Site;socioeconomics;Source;South Africa;South African;Southern Africa;Standardization;success;Surveys;System;Time trend;tool;Training;Translating;trend;Universities;verbal;Wit;Woman;Work

PROJECT_TITLE: Core B - Fieldwork and Data Core


NIH_SPENDING_CATS: Dietary Supplements;Genetics;Nutrition

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE Retinoic acid, a physiological active derivative of Vitamin A, controls multiple processes during embryonic development in a concentration-dependent manner. Dysregulation of retinoic acid concentration results in numerous developmental defects and congenital diseases, but the mechanism responsible for establishing the correct spatiotemporal pattern of retinoic acid concentration is not known. The studies proposed in this application will test a hypothesis that the retinoic acid concentration pattern is controlled by a unique antagonistically bifunctional retinoid oxidoreductase complex that dynamically regulates the output of retinaldehyde, the immediate precursor of retinoic acid.

PI_NAMEs: BELIAEVA, OLGA V (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Address;All-Trans-Retinol;Anabolism;animal tissue;Attenuated;Automobile Driving;Back;Binding;Buffers;Cells;Complex;Cytoplasm;Data;Defect;Development;Developmental Process;Dietary intake;Disease;Ectopic Expression;Embryo;Embryonic Development;Ensure;Environment;Enzymatic Biochemistry;Enzymes;Epigenetic Process;Etiology;Exercise;Fertilization;Fluorescence Resonance Energy Transfer;Foundations;Future;Generations;Genes;Genetic Transcription;genome editing;Homeobox Genes;Homeostasis;Human;In Vitro;in vivo;Individual;Knock-in;knockout gene;Ligands;malformation;Modeling;Monitor;mosaic;Mutation;NADH;NADP;novel;Nuclear;Orthologous Gene;Output;oxidation;Oxidoreductase;Pathway interactions;Pattern;Physiological;prevent;Process;progenitor;Property;Proteins;Publishing;receptor;Recycling;Regulation;response;Retinaldehyde;Retinoic Acid Binding;Retinoic Acid Receptor;Retinoids;Retinol dehydrogenase;Role;self-renewal;sensor;Signal Transduction;small molecule;spatiotemporal;Testing;transcription factor;Tretinoin;Visualization;Vitamin A;Work;Zebrafish;Zebrafish Proteins

PROJECT_TITLE: Role Of Retinoid Oxidoreductase Complex In Controlling The Embryonic Development

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: RAMSAY, MICHELE MICHELE (contact)

PROJECT_TERMS: African;Aging;Amyloid beta-Protein;Artificial Intelligence;biobank;Bioinformatics;Biological;Biological Markers;Biological Process;Biological Sciences;Biometry;Blood;Blood capillaries;Blood Glucose;Blood Pressure;Body Composition;Brain natriuretic peptide;Cardiac;Cardiometabolic Disease;Categories;Characteristics;clinically relevant;cognitive function;cohort;Collaborations;Collection;Communities;comparative;Computer software;Data;Data Analyses;Dementia;dementia risk;disorder risk;DNA;Dryness;Echocardiography;Electrocardiogram;Ensure;Epidemiology;Epigenetic Process;Evaluation;genetic association;genomic data;Genomics;Genotype;Glial Fibrillary Acidic Protein;handheld mobile device;Health;health application;Health Transition;Heart failure;HIV;Image;improved;indexing;Inflammation;Infrastructure;interest;International;Laboratories;Length;Light;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Measures;Medical Research;Methylation;Molecular;Morbidity - disease rate;mortality;neurofilament;neuroimaging;novel;novel marker;Participant;Pathogenicity;pharmacologic;Phenotype;Physiological;Plasma;point of care;Population;Procedures;Process;programs;Public Health;Quality Control;radiological imaging;Reporting;Research;Research Project Grants;Resources;response;risk stratification;Rural;sample collection;Sampling;Sodium;South Africa;specific biomarkers;Spottings;Surveys;System;tau-1;telomere;Test Result;Therapeutic Intervention;Time;Training;Troponin I;Trust;United States National Institutes of Health;Universities;Urine;Venous;Wit

PROJECT_TITLE: Core C - Biomarker and Biobanking Core


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: AMHERST

ORG_DEPT: PHYSIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Using dopaminergic neurons differentiated from induced pluripotent stem cells or directly converted from skin fibroblasts or urinary tract cells, we will identify molecular signatures that can distinguish normal subjects from idiopathic Parkinson’s disease patients and between Parkinson’s patients with or without tremor at onset. The project will significantly help diagnosis of Parkinson’s disease.

PI_NAMEs: FENG, JIAN  (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: Address;Age;Back;Biological Markers;biomarker development;Bradykinesia;Categories;Cells;Clinical;Clinical Trials Design;cohort;Complex;Development;Diagnosis;Diagnostic;Disease;disease diagnosis;disorder subtype;Dopamine;dopaminergic neuron;endophenotype;Fibroblasts;Gene Expression;Gene Expression Profile;Genes;Genetic;Goals;Human;Idiopathic Parkinson Disease;improved;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;innovation;innovative technologies;insight;Laboratories;Methods;Midbrain structure;Molecular;Molecular Profiling;Neuronal Differentiation;Neurons;new technology;novel;Onset of illness;Oxidative Stress;Parkinson Disease;Patients;Physiology;posture instability;predictive marker;Preparation;Prognosis;Property;Research;research and development;Rest Tremor;Sampling;segregation;Series;sex;Shapes;Skin;stem;Stem Cell Development;stem cell technology;Symptoms;Testing;therapeutic development;Tissue-Specific Gene Expression;Tremor;Urinary tract

PROJECT_TITLE: Molecular Segregation of Parkinson’s Disease by Patient-Derived Neurons

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative Anxiety disorders ̶one of the most common mental health conditions in the US and globally ̶increase the risk for depression and suicide in adolescence and adulthood, with levels of symptoms increasing dramatically during early adolescence, especially in girls. This longitudinal study will examine the effects of pubertal hormones on the development of brain circuitry implicated in emotion regulation in early adolescent anxious boys and girls and test to what extent these effects are linked to sex differences in increases in anxiety symptoms and levels of threat reactivity in a real-world context. Results from this study will provide important new information about brain changes during puberty that could lead to the discovery of sex-specific targets of intervention grounded in neurodevelopment thereby maximizing efficacy.

PI_NAMEs: LADOUCEUR, CECILE D. (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Age;Amygdaloid structure;Anxiety;Anxiety Disorders;anxiety symptoms;anxious;Biological;boys;Brain;brain circuitry;Childhood;Clinical;dehydroepiandrosterone;Development;Diagnosis;Diffusion;early adolescence;Early identification;Effectiveness;emotion regulation;Emotional;Environmental Risk Factor;Estradiol;Exhibits;Female;Functional Magnetic Resonance Imaging;Galvanic Skin Response;gamma-Aminobutyric Acid;Generalized Anxiety Disorder;girls;Glutamates;Goals;Hair;Heart Rate;heart rate variability;Hormones;Image;Impairment;indexing;Intervention;Interview;Link;Longitudinal Studies;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Maintenance;Measures;Mental Depression;Mental Health;Modeling;multimodal neuroimaging;National Institute of Mental Health;neural;neural network;neurodevelopment;Participant;Patient Self-Report;peer;Pharmaceutical Preparations;Physiological;Prefrontal Cortex;Prevention;protective factors;pubertal timing;Puberty;Questionnaires;recruit;Reporting;Research Domain Criteria;Resolution;respiratory;Rest;Risk;Role;Saliva;Sampling;sex;Sex Differences;Sinus Arrhythmia;Social Anxiety Disorder;Stimulus;Structure;Suicide;Symptoms;System;Testing;Testosterone;Time;Trier Social Stress Test;ultra high resolution;Visit;white matter;Youth

PROJECT_TITLE: Puberty-related development of fronto-amygdala circuitry in anxious youth: A multimodal neuroimaging study with ultra-high resolution MRI scanner (7T)

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

PROJECT_TERMS: Address;Affect;Africa South of the Sahara;African;Age Years;Aging;aging brain;aging population;Algorithms;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Biological;Biological Markers;Birth;Blood;blood-based biomarker;Calibration;Categories;Characteristics;Child;Cognition;Cognitive;cognitive change;cognitive function;cognitive reserve;cognitive testing;cohort;Collaborations;Communities;Consensus;Country;Credentialing;Data;data harmonization;Dementia;dementia risk;Diagnosis;diagnostic algorithm;Education;Educational process of instructing;epidemiologic data;Epidemiology;experience;Generations;Glial Fibrillary Acidic Protein;global health;Goals;Health;Health and Retirement Study;Health system;Incidence;Income;informal learning;innovation;insight;International;late life;life history;Linguistics;literacy;Lived experience;Longitudinal Studies;low and middle-income countries;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measurement;Measures;men;mild cognitive impairment;Nerve Degeneration;Neurobehavioral Manifestations;Neurobiology;neuroimaging;neuropathology;Neuropsychological Tests;Neuropsychology;novel;older adult;Outcome;Parents;Participant;Pathway interactions;Pattern;Performance;Phenotype;Plasma;Population;Population Study;Prevalence;Prevention strategy;Protocols documentation;Psychometrics;Research;Resources;Respondent;Risk;Risk Factors;Role;Sampling;Severities;Shapes;Sister;skills;social;Social Change;Social Conditions;social determinants;social factors;Social Network;Social support;South Africa;South African;Surveys;Symptoms;tau-1;Techniques;Translating;Validity and Reliability;Variant;Woman;Work

PROJECT_TITLE: Project 1 - Cognitive Function and Dementia


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative  Endothermic animals including humans need to maintain their brain temperature steady while their interior body temperature changes during exercise or intake of hot or cold fluids. Critical for survival during prolonged exposure to extreme thermal conditions, the brain temperature has to be maintained even when thermoregulation of peripheral body parts becomes difficult. Having identified the first molecular marker for temperature-sensitive neurons in the preoptic area of the anterior hypothalamus, we propose to elucidate the functional circuitry of central neurons in the brain, for monitoring brain temperature changes and mediating homeostatic thermoregulation.

PI_NAMEs: JAN, LILY Y (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Animals;Anterior Hypothalamus;Area;Behavior;Body part;Body Temperature;Body Temperature Changes;Brain;Brain-Derived Neurotrophic Factor;Cells;circadian;Consumption;Detection;Development;Dorsal;drinking;Electrophysiology (science);Environment;Exercise;Exposure to;Feedback;feeding;Frostbite;Glutamates;Heat Losses;Homeostasis;Hormones;Human;Hypothalamic structure;induced hypothermia;Intake;Lateral;Liquid substance;Maintenance;Medial;Mediating;molecular marker;Monitor;Mus;Nature;neuronal circuitry;Neurons;optogenetics;Organ;patch clamp;Periodicity;Peripheral;Physiologic Thermoregulation;pituitary adenylate cyclase activating polypeptide;Posterior Hypothalamus;predictive modeling;Preoptic Areas;preoptic nucleus;Production;Prostaglandin D2;rate of change;receptor;Regulation;response;Signal Transduction;single-cell RNA sequencing;Sleep;Slice;Structure of dorsomedial hypothalamic nucleus;suprachiasmatic nucleus;Synapses;Synaptic Transmission;System;Temperature;Testing;Tracer;Variant

PROJECT_TITLE: Central neuronal circuitry for homeostatic thermoregulation modulated by brain temperature


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SALT LAKE CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: HUNTSMAN CANCER INSTITUTE PROJECT NARRATIVE Huntsman Cancer Institute (HCI) at the University of Utah is the only National Cancer Institute-designated Cancer Center in Utah and the vast area of the five-state Mountain West; HCI effectively promotes research and public policy to address pressing needs of this region, particularly the special cancer burdens of rural/frontier populations. We care deeply about the next generation of cancer researchers and have implemented a portfolio of programs, including special initiatives for rural and disadvantaged youth. Through the Cancer Center Support Grant, we will make high-impact scientific discoveries across basic laboratory; clinical; and prevention, cancer control, and population-based research, and disseminate these findings to improve outcomes for individuals impacted by cancer.

PI_NAMEs: ULRICH, CORNELIA M (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;anti-cancer research;Area;Award;biobank;Bioinformatics;Biological Assay;Biometry;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Patient;cancer research center director;cancer risk;cancer therapy;career;Caring;Catchment Area;Cause of Death;Cell Differentiation process;cell growth;Cells;Characteristics;Charge;Clinic;Clinical;clinical application;Clinical Data;Clinical Protocols;Clinical Research;Clinical Trials;cohort;Collaborations;college;Communication;community based service;community engagement;Community Outreach;Consultations;data management;Dedications;Development;Direct Costs;Disadvantaged;Doctor of Philosophy;early phase clinical trial;Education;empowerment;Enrollment;Environment;Equity;Exclusion;Extramural Activities;Faculty;faculty mentor;Faculty Recruitment;faculty support;Fostering;frontier;Funding;Genetic;Genetic Counseling;Genomics;Geographic Locations;Grant;Health;health disparity;Health Personnel;Health Professional;Hospitals;Huntsman Cancer Institute at the University of Utah;Idaho;improved;improved outcome;Incidence;Individual;Informatics;innovation;Institution;instrumentation;Intervention;Investigational Therapies;Investments;K-12 Education;Knowledge;Laboratories;Laboratory Research;Leadership;Malignant Neoplasms;Measures;medical specialties;Melanoma;member;Mission;molecular pathology;Monitor;Montana;mortality;National Cancer Institute;National Cancer Institute Cancer Centers Program;Nevada;next generation;Nuclear;organizational structure;Outcome;outreach;patient population;Patients;Peer Review;Population;population based;Population Database;Population Research;Population Sciences;Prevention;Productivity;programs;Protocols documentation;Public Health;Public Policy;Publications;Publishing;recruit;Regulation;Research;Research Institute;Research Personnel;Resource Sharing;Resources;response;Risk;Role;Rural;Science;Services;Shapes;Statutes and Laws;Strategic Planning;Training;Training Programs;Translational Research;Translations;treatment trial;underserved students;Universities;Utah;Work;Wyoming;Youth

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: LLOYD, SCOTT  (contact)

PROJECT_TERMS: Annual Reports;anti-cancer research;Applications Grants;Award;Awareness;Basic Science;beneficiary;Budgets;Cancer Center;Cancer Center Support Grant;cancer clinical trial;career;Catchment Area;Characteristics;Clinical;Clinical Research;Clinical Trials;combat;Communication;Comprehensive Cancer Center;computer infrastructure;computer network;Computer software;cost effective;Database Management Systems;Databases;Dedications;Development;Documentation;Education;Employee;Environment;Equipment;experience;Faculty;Faculty Recruitment;faculty support;flexibility;Funding;Goals;Grant;Head;Human Resources;improved;informatics shared resource;innovation;Journals;Leadership;Maintenance;Malignant Neoplasms;Marketing;Medicine;meetings;member;Mission;Monitor;National Cancer Institute;Office of Administrative Management;operation;Outcome;outreach;Patients;Pilot Projects;Policies;Population Research;Population Sciences;Positioning Attribute;Process;programs;recruit;Research;research and development;Research Institute;Research Personnel;Resource Sharing;Resources;Science;Security;service delivery;Services;software systems;Strategic Planning;Strategic vision;success;symposium;System;Telephone;trial planning;Universities;Utah;Work

PROJECT_TITLE: Cancer Center Administration


NIH_SPENDING_CATS: Cancer;Genetics;Prevention

PI_NAMEs: CAMP, NICOLA J. (contact)

PROJECT_TERMS: Address;advanced analytics;analytical tool;anti-cancer research;APC gene;Area;Behavior;Behavioral;Behavioral Research;Biomedical Research;Cancer Center;Cancer Center Support Grant;Cancer Etiology;Cancer Family;Cancer Patient;Caring;Catchment Area;Censuses;Chromosome Mapping;Clinic;Clinical Investigator;Clinical Trials;Collaborations;community engagement;Community Outreach;Complex;complex data;Computerized Medical Record;cost;cost effective;Creativeness;Data;Data Analyses;data quality;data resource;Data Set;data sharing networks;Data Sources;data tools;data warehouse;Databases;design;Discipline;Disease;DNA Sequence Alteration;Doctor of Philosophy;Emergency department visit;Ensure;Epidemiology;epidemiology study;Evaluation;Exposure to;Faculty;Familial Adenomatous Polyposis Syndrome;Family;Family history of;Family Study;Funding;gene discovery;Genealogy;Generations;Genes;Genetic;genetic linkage;genetic pedigree;genetic testing;Geography;Grant;Guidelines;Health;Health Services Research;Healthcare;High-Risk Cancer;Human;human disease;improved;Incidence;Individual;Infrastructure;Institutional Review Boards;Investigation;kindred;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Manuscripts;Medical;Medical Records;Medicare;member;Mission;Molecular Genetics;National Cancer Institute;NCI Center for Cancer Research;neoplasm registry;novel;Oncogenes;Outcome Study;Pattern;Peer Review;Population;Population Analysis;Population Database;Population Study;Predisposition;Preparation;Prevention;Preventive;privacy protection;Productivity;Protocols documentation;Public Health;Publications;Quality Control;racial diversity;Records;recruit;Research;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk Assessment;Science;Secure;SEER Program;Services;Source;Techniques;Translations;United States;Universities;Utah;Work;Writing

PROJECT_TITLE: Utah Population Database (UPDB)


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetic Testing;Genetics;Health Services;Human Genome;Prevention

PI_NAMEs: KOHLMANN, WENDY K (contact)

PROJECT_TERMS: Address;Adherence;anti-cancer research;Applications Grants;Area;Basic Science;Behavioral Research;Cancer Biology;cancer care;Cancer Center;Cancer Center Support Grant;cancer genetics;cancer predisposition;cancer risk;Catchment Area;Chemoprevention;Clinic;Clinical;clinical care;clinical implementation;Clinical Investigator;clinical phenotype;Clinical Research;Clinical Trials;clinically significant;cohort;Collaborations;Collection;Communication;Consultations;Data;design;Effectiveness;Electronic Health Record;Ensure;ethical, legal, and social implication;Ethics;Familial Adenomatous Polyposis Syndrome;Funding;gene discovery;Genes;Genetic;genetic analysis;Genetic Anticipation;Genetic Counseling;genetic counselor;genetic information;Genetic Research;Genetic Services;genetic testing;Germ Lines;Goals;Grant;Guidelines;Hereditary Malignant Neoplasm;Hereditary Neoplastic Syndromes;Image;Individual;Inherited;innovation;Intervention;Malignant Neoplasms;Medical Genetics;member;Methods;Mission;National Cancer Institute;novel;novel strategies;Oncology;Outcome;Participant;Patient-Focused Outcomes;Patients;Peer Review;Population;Population Policies;primary care patient;Principal Investigator;Program Research Project Grants;programs;Protocols documentation;Publications;Qualifying;Recording of previous events;recruit;Research;Research Design;Research Institute;Research Personnel;Resource Sharing;Resources;Risk;Risk Management;Rural Population;Sampling;Science;Scientific Advances and Accomplishments;screening;Services;Syndrome;tool;Translating;translational genetics;Translations;Utah;Work

PROJECT_TITLE: Genetic Counseling (GC)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Black older adults and their caregivers in the United States are unduly burdened by poor health outcomes related dementia. Black immigrants are poised to make up a significant portion of the Black older adult population and are at risk of poor health outcomes related to dementia, similar to U.S. born Black older adults. The present training and research will directly facilitate the development of interventions that meet the intersecting cultural and social needs of Black immigrants with dementia and their caregivers, which is an important first step towards improving their health.

PI_NAMEs: NKIMBENG, MANKA  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: acceptability and feasibility;Address;African;African Caribbean;Alzheimer's disease caregiver;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Area;Behavior Therapy;Behavioral;Belief;Black race;career;career development;caregiver education;caregiver quality of life;caregiver stress;Caregivers;caregiving;Caring;Clinical Trials;Collaborations;Communities;community engagement;Consultations;Country;cultural values;Data;Data Analyses;Day Care;Dedications;Dementia;dementia burden;dementia care;Dementia caregivers;dementia caregiving;design;Development;Diagnosis;Discrimination;Disparity;Disparity population;Distress;Education;Education Projects;Educational Intervention;effective intervention;efficacy testing;empowerment;ethnic minority;ethnic minority population;evidence base;Evidence based intervention;experience;Family;Feasibility Studies;feasibility testing;Friends;Goals;Grant;Health;health care availability;health disparity;health inequalities;Health Services Accessibility;Home Care Services;Hour;Immigrant;Immigrant community;Immigrant family;Immigration;Impaired cognition;improved;informal caregiver;Intervention;Interview;Knowledge;Language;Long-Term Care;Managed Care;Memory Loss;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Minority;minority communities;Modeling;older adult;Outcome;Participant;Peer Review;Perception;Persons;poor health outcome;Population;programs;psychoeducational intervention;Publications;racial minority;racial minority population;Research;Research Training;Resources;Risk;Sampling;Scientist;Services;skills;social;social factors;social stigma;Statistical Methods;stress management;Subgroup;symposium;Testing;therapy development;Training;United States;United States National Institutes of Health;Writing

PROJECT_TITLE: Developing a Culturally Immersive Psychoeducational Intervention for Black Immigrant Older Adults with Dementia and Their Caregivers: The Black Immigrant Project

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Prevention;Social Determinants of Health

PI_NAMEs: TOLLMAN, STEPHEN  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Affect;Africa;Africa South of the Sahara;African;Age Years;Aging;aging population;Behavioral;burden of illness;Cardiometabolic Disease;care delivery;Cause of Death;Child Care;Chronic;Chronic Care;Cognition;Cognitive;cognitive function;cohort;Community Health Aides;Community Healthcare;Country;Coupled;COVID-19;Data;Dementia;Development;Diabetes Mellitus;disease phenotype;disorder prevention;disorder risk;Distress;Dyslipidemias;Echocardiography;Economics;Ensure;Epidemiology;Event;Excretory function;follow-up;Food;food insecurity;Goals;Grant;Health;health disparity;Health Policy;Health system;Healthcare;healthy aging;Heart failure;HIV;Home;Hospital Records;Household and Family;Hypertension;Impaired cognition;improved;Incidence;Income;Infrastructure;Intervention;Life Expectancy;Link;Longitudinal Studies;low and middle-income countries;Measurement;Measures;Medicine;men;Methods;mild cognitive impairment;mortality;Myocardial Infarction;Myocardial Ischemia;novel;novel marker;Obesity;older adult;Older Population;Outcome;Participant;Pathway interactions;Patient Self-Report;Pensions;Phenotype;Physical Function;Play;Policies;Population;Prevalence;Prevention;Primary Care;programs;rate of change;Regulation;Research;Resource Allocation;Resources;Risk;Risk Factors;Risk Reduction;Role;Rural;rural South Africa;Sampling;Schools;Self Care;social;social determinants;Social Policies;Social support;Sodium;Sodium Chloride;South Africa;South African;Stroke;Surveys;System;Testing;Urine;Vascular Diseases;vascular risk factor;Woman

PROJECT_TITLE: Project 2 - Cardiometabolic Disease in HAALSI


PI_NAMEs: DALLEY, BRIAN  (contact)

PROJECT_TERMS: Address;algorithm development;anti-cancer research;Bioinformatics;Budgets;Cancer Biology;cancer care;Cancer Center;Cancer Center Support Grant;Clinical;clinical care;clinical diagnostics;Clinical Research;Computer software;Consultations;cost;cost effective;Data;Data Analyses;Data Set;Dedications;Diagnostics Research;Discipline;Doctor of Philosophy;Education;Ensure;epigenetic profiling;Evaluation;experience;Experimental Designs;experimental study;Funding;Generations;Genomic approach;Genomics;Grant;Human Resources;improved;Individual;Infrastructure;innovation;Institution;Instruction;instrument;instrumentation;Investigation;Investments;Libraries;Malignant Neoplasms;Manuscripts;member;Modernization;Molecular;new technology;next generation sequencing;Oncology;participant enrollment;Patients;Peer Review;Play;Preparation;Privatization;Process;programs;Protocols documentation;Publications;Qualifying;recruit;Research;Research Institute;Research Personnel;Research Support;Resource Sharing;Resources;Sampling;Science;Scientist;Services;single cell genomics;Site;synergism;Technology;tool;Training;translational genomics;Translational Research;Universities;Utah;Work

PROJECT_TITLE: High-Throughput Genomics and Bioinformatic Analysis (GBA)


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: In pancreatic cancer, 95% of patients possess mutational activation of the KRAS oncoprotein, leading to persistent activation of the RAF-MEK-ERK mitogen-activated protein kinase cascade. Our studies have targeted this pathway as a strategy to create a dependence on autophagy, which we can subsequently co-target for the treatment of KRAS-mutant pancreatic cancer. We propose studies to facilitate further clinical advancement of novel combination anti-autophagy strategies.

PI_NAMEs: BRYANT, KIRSTEN L (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Acute;Address;APC gene;Apoptotic;Autophagocytosis;Biological;Biological Markers;BRAF gene;cancer cell;Cancer Etiology;cancer therapy;cancer type;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cells;Cessation of life;Clinical;clinical candidate;clinical efficacy;Clinical Trials;Colorectal Cancer;Combined Modality Therapy;CRISPR/Cas technology;Dependence;Development;Dissection;DNA Damage;DNA Repair;Drug Combinations;Eating;effectiveness evaluation;Energy-Generating Resources;Event;Frequencies;Future;Genes;Genetic;Genome;Growth;Hydroxychloroquine;Impairment;improved;In Vitro;inhibition of autophagy;inhibitor;Knowledge;KRAS2 gene;Label;Large Intestine Carcinoma;Light;loss of function;Lysosomes;macromolecule;Malignant neoplasm of pancreas;Malignant Neoplasms;MAPK3 gene;Mediator;MEKs;member;Metabolic;Metabolism;Mitogen-Activated Protein Kinases;mouse model;mutant;Mutate;Mutation;new combination therapies;novel;Nutrient;Oncoproteins;Organelles;Organoids;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;pharmacologic;Pharmacotherapy;Process;Protein Kinase;protein kinase inhibitor;Protein-Serine-Threonine Kinases;Proteomics;Publishing;RAS driven cancer;Recycling;Regulation;Reporting;research clinical testing;Resistance;resistance gene;response;Role;Serine;Source;standard of care;Starvation;Survival Rate;targeted treatment;Therapeutic;tumor;tumor progression;Tumor Promotion;tumorigenic;Up-Regulation

PROJECT_TITLE: Mechanistic dissection and inhibitor targeting of autophagy in RAS driven cancers

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Biotechnology;Cancer;Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: POST, ANDREW RONALD (contact)

PROJECT_TERMS: Acceleration;Administrator;anti-cancer research;Architecture;Authorization documentation;Basic Science;cancer care;Cancer Center;Cancer Center Support Grant;Clinical;Clinical Data;Clinical Research;Clinical Sciences;Clinical Trials;cohort;Computer software;Consultations;cost effective;Custom;Data;data access;Data Analyses;data ecosystem;data integration;data management;Data Science;Data Scientist;Data Security;data sharing;Data Sources;data warehouse;Database Management Systems;Databases;Dedications;design;Development;Diagnostic;Disease;Doctor of Philosophy;Economic Models;Ecosystem;Evaluation;flexibility;Funding;genomic data;Genomics;Goals;Grant;Healthcare;Heart Research;Individual;Informatics;informatics infrastructure;informatics shared resource;Information Systems;Infrastructure;innovation;Institution;Internet;interoperability;Investigation;Laboratories;Leadership;Link;Maintenance;Malignant Neoplasms;Management Information Systems;Manuscripts;Medical Records;member;Mission;Modeling;Molecular Target;multiple omics;Natural Language Processing;Nature;NCI Center for Cancer Research;Oncology;operation;Patients;Peer Review;Population;Population Database;Population Research;Population Sciences;precision oncology;Principal Investigator;process improvement;Productivity;programs;query tools;Reporting;Research;Research Institute;Research Personnel;Resource Sharing;Resources;Science;Services;Software Engineering;Source;success;Support System;System;Technology;Testing;Tissue Banks;Training;Training and Education;translational pipeline;Translational Research;Utah;Visualization;Work

PROJECT_TITLE: Research Informatics (RI)


PI_NAMEs: FILLMORE, GARY CHRISTOPHER (contact)

PROJECT_TERMS: Accreditation;Address;Advanced Malignant Neoplasm;American;anti-cancer research;Basic Science;biobank;Biological;Blood;Blood specimen;Body Fluids;Breast Cancer Model;cancer care;Cancer Center;Cancer Center Support Grant;cancer diagnosis;Cancer Patient;Clinical;clinical care;Clinical Sciences;Clinical Trials;Collection;college;Consent;cost;cost effective;Cost Savings;Development;Diagnostic Services;Doctor of Philosophy;effective intervention;Ensure;experimental study;Formalin;Freezing;Funding;genetic analysis;Goals;Grant;Guidelines;Histologic;Histology;Hospitals;Human;human tissue;improved;International;Laboratories;Liquid substance;Malignant neoplasm of ovary;Malignant Neoplasms;Melanoma;member;Methods;Molecular Diagnostic Testing;molecular diagnostics;molecular pathology;molecular subtypes;Monitor;National Cancer Institute;novel;Nucleic Acids;Operative Surgical Procedures;Paraffin Embedding;Pathogenesis;Pathologist;Pathology;Patients;Peer Review;Policies;Preparation;Price;Procedures;Process;programs;Protocols documentation;Publications;Recommendation;repository;Research;Research Institute;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;Sampling;Science;Services;Societies;Specialized Program of Research Excellence;Specimen;Stains;Standardization;Structure;Technology;Tissues;Translational Research;tumor;Universities;Utah;Work

PROJECT_TITLE: Biorepository and Molecular Pathology (BMP)


PI_NAMEs: BOUCHER, KENNETH MICHAEL (contact)

PROJECT_TERMS: Award;Bioinformatics;Biometry;Biostatistical Methods;Biostatistics Core;Biostatistics Shared Resource;Cancer Center;Cancer Center Support Grant;cancer epidemiology;cancer health disparity;Cancer Research Project;cancer risk;cancer therapy;Caring;Catchment Area;Clinical;Clinical Trials;Clinical Trials Design;Complex;Core Grant;cost effective;Cost Effectiveness Analysis;Data;Data Analyses;design;Development;dimension reduction;Doctor of Philosophy;early-career faculty;Ensure;Formulation;frontier;Funding;Future;genomic data;Genomics;Grant;improved;Individual;Informatics;Information Dissemination;innovation;interest;K-Series Research Career Programs;Laboratories;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Melanoma;member;Mentors;Meta-Analysis;Methodology;Methods;Mission;Modeling;Monitor;novel;Patient-Focused Outcomes;Population Database;Population Sciences;Postdoctoral Fellow;predictive modeling;Prevention;Process;Productivity;Program Research Project Grants;programs;Publications;Reporting;Reproducibility;Research;Research Design;Research Institute;Research Personnel;Research Project Grants;Resource Sharing;Resources;Rural;Science;Sequential Multiple Assignment Randomized Trial;Services;Site;Specialized Program of Research Excellence;Statistical Methods;student mentoring;success;Techniques;Training;Utah;Work;Workload

PROJECT_TITLE: Cancer Biostatistics (CB)


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Brain Disorders;Neurosciences

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative Oligodendrocytes play an important role in a number of brain injuries and neurological diseases. This proposal details an innovative in vivo imaging technology to explore how these cell types cause negative tissue responses to intercortical microelectrodes in the cortex. Transgenic indicators, electrode design, pharmaceutical intervention strategies, and gliomodulation technologies will be examined to improve oligodendrocyte health and recording performance over time.

PI_NAMEs: CAMBI, FRANCA ;KOZAI, TAKASHI DANIEL YOSHIDA (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Affect;Aneurysm;antagonist;Astrocytes;Autopsy;Axon;Basic Science;Blood - brain barrier anatomy;Blood flow;Brain;brain computer interface;Brain Injuries;Calcium;cell type;Cells;Chronic;Cicatrix;Clinical;Clinical Sciences;cost;Cuprizone;Data;Demyelinations;density;design;Devices;Electrodes;Electrophysiology (science);Encapsulated;Engineering;Failure;flexibility;Foreign Bodies;functional restoration;Gene Expression Profiling;Health;Hemorrhage;Hippocampus;Histology;Human;Imaging technology;Impairment;Implant;implantation;improved;in vivo;in vivo imaging;Individual;Inflammatory;Injury;injury recovery;innovation;Intervention;Ischemia;Knowledge;Lead;Mechanics;Metabolic;Methods;Microelectrodes;Microglia;Molecular;Molecular Target;Motor;Motor Cortex;multiphoton imaging;multiphoton microscopy;Mus;Muscarinic Acetylcholine Receptor;Myelin;myelination;Nerve Degeneration;Nervous System Disorder;neural;neural implant;neural network;neural stimulation;Neurodegenerative Disorders;Neuroglia;neuron loss;Neurons;neuroprosthesis;neuroprotection;Neurosciences;novel;oligodendrocyte progenitor;Oligodendroglia;Outcome;Output;Penetration;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Pharmacological Treatment;Physiology;Play;Process;Publishing;Recovery of Function;remyelination;Reporter;response;Role;Site;Source;stem cells;Stroke;System;Technology;Testing;Time;Tissues;Toxin;Transgenic Animals;Transgenic Organisms;Translations;Traumatic Brain Injury;ultrasound;Universities;Visual;Visual Cortex;wireless;Work

PROJECT_TITLE: Mechanisms of Oligodendrocyte Activity on Chronic Brain Implants and Recording Performance

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Infectious Diseases;Neurodegenerative

PI_NAMEs: BARNIGHAUSEN, TILL  (contact)

PROJECT_TERMS: Adult;African;Age;Aging;aging population;antiretroviral therapy;Behavioral;Biological Markers;Cardiometabolic Disease;Caring;Characteristics;Chronic;Cluster Analysis;Cognitive;cohort;Communities;Continuity of Patient Care;Country;Data;Data Science;Dementia;design;Development;Diabetes Mellitus;Disease;Ensure;Epidemic;falls;Frequencies;Goals;Health;Health Transition;HIV;HIV Infections;hypercholesterolemia;Hypertension;Hypertriglyceridemia;Impaired cognition;Impairment;Knowledge;Long-Term Effects;Longitudinal Studies;Measures;Mental Depression;mild cognitive impairment;Morbidity - disease rate;multiple chronic conditions;Nature;Obesity;older adult;Older Population;Overweight;Persons;Physical Function;physical impairment;Policies;Population;Population Research;Prevalence;programs;psychologic;psychosocial;Public Health;Quasi-experiment;Regimen;Research;Research Personnel;Rural;side effect;social;Social Policies;South Africa;Southern Africa;Surveys;Testing;Time;trend;Wit;Work

PROJECT_TITLE: Project 3 - Impairment and multimorbidity among people aging with HIV and ART in South Africa


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Dissemination and Implementation Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: ANN ARBOR

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The goal of the proposed project is to address the gap in current research on public perspectives about ethical best practices and the impact of Artificial intelligence-enhanced Clinical Decision Support (AI-CDS) on the trust of the public. We propose to focus on policy and practice options such as certification, notification, and product labeling related to essential, endemic issues in the AI-CDS ecosystem: transparency, privacy, equity, non- maleficence, accountability, and utility (Aim 1 and Aim 2). For Aim 3, we evaluate key attributes for product labeling and an accompanying multi-dimensional metric of trust reflective of the Food and Drug Administration's system of categorizing software used as a medical device.

PI_NAMEs: PLATT, JODYN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Academy;Accountability;Address;Adoption;Adult;Affect;Age;algorithm development;Apple;Applications Grants;Artificial Intelligence;Artificial Intelligence enhanced;Attitude;Big Data;Black Box;British;Caring;Case Study;Certification;Classification;Clinical;clinical decision support;Collaborations;Communication;Communities;Competence;Computer software;cost;Data;data sharing;deliberative democracy;design;digital;Dimensions;Ecosystem;Ensure;Epidemiology;Equity;ethical, legal, and social implication;Ethics;evidence base;expectation;follow-up;Generations;Genomics;Geography;Goals;Growth;Guidelines;Health;health data;health management;Health Policy;Health Professional;Health Sciences;Health system;Heart Diseases;improved;Individual;Industry;innovation;Institution;Interview;Investigation;Investments;Knowledge;Label;Leadership;Learning;learning algorithm;learning network;longitudinal analysis;machine learning algorithm;Measures;Medical;Medical Device;Medicine;Methods;Michigan;Nonmaleficence;Notification;Online Systems;Outcome;outreach;Participant;patient oriented;patient population;patient portal;Patients;Perception;point of care;Policies;Population;Precision Health;precision oncology;preference;Privacy;Privatization;Probability;Product Labeling;Provider;Public Health;Public Participation;public trust;Recommendation;Research;Risk;Sampling;Security;social;Source;Surveys;System;Technology;Trust;United States Agency for Healthcare Research and Quality;United States Food and Drug Administration;United States National Institutes of Health;Universities;Vendor;wearable data;Women's Health

PROJECT_TITLE: Public trust of artificial intelligence in the precision CDS health ecosystem


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: RUTTER, JARED P (contact)

PROJECT_TERMS: Appointment;Area;Attention;Basic Science;Biochemical;Bioinformatics;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;cancer genetics;Cancer-Predisposing Gene;Catchment Area;Cell Differentiation process;cell growth;Cell Nucleus;Cells;Chromatin;Clinic;Clinical;Clinical Investigator;Clinical Sciences;Collaborations;college;design;Development;Diagnostic;Direct Costs;Disease;DNA Damage;DNA Repair;Doctor of Philosophy;Education;Effectiveness;Epigenetic Process;Faculty;Funding;gene discovery;Gene Expression Regulation;gene network;Genes;Genetic Transcription;Genome Stability;Genomics;Goals;Grant;Guidelines;Incidence;individualized medicine;innovation;Investigation;Investigational Therapies;Journals;Leadership;Link;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Melanoma;member;Metabolic;Metabolism;Mission;National Cancer Institute;next generation;Normal Cell;Nuclear;Oncogenic;Paper;Pathway interactions;patient oriented research;Peer Review;Play;Population;Population Sciences;posttranscriptional;Pre-Clinical Model;Prevention;Principal Investigator;Process;programs;Publications;Publishing;Regulation;repaired;Reporting;Research;Research Institute;Research Personnel;Resource Sharing;response;RNA metabolism;Role;Schools;Science;Scientist;success;Training and Education;transcription factor;Translating;translational impact;translational potential;translational research program;Translations;tumor metabolism;tumorigenesis;Universities;Utah

PROJECT_TITLE: Nuclear Control of Cell Growth and Differentiation (NC)


NIH_SPENDING_CATS: Cancer;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: HOLMEN, SHERI L (contact)

PROJECT_TERMS: Acceleration;Address;American Cancer Society;Area;Award;Back;Basic Science;biomarker development;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Model;cancer prevention;cancer therapy;Cause of Death;Cell Communication;Cell Cycle Stage;Cell Death;Cell Fate Control;cell motility;Cell Proliferation;Cells;Cellular biology;Clinic;Clinical;Collaborations;college;Department of Defense;Development;diagnostic development;Disease;Disseminated Malignant Neoplasm;Distant;Doctor of Philosophy;Drosophila genus;Drug Targeting;Education;Effectiveness;Embryo;Environment;Fostering;Foundations;Funding;Genetically Engineered Mouse;Goals;Grant;human cancer mouse model;Infrastructure;insight;interdisciplinary collaboration;Invaded;Investigation;Investigational Therapies;investigator-initiated trial;Journals;Malignant Neoplasms;malignant state;Mediating;member;Mission;Modeling;Motility;Neoplasm Metastasis;neoplastic cell;next generation;novel;novel strategies;novel therapeutics;Organoids;Paper;Pathway interactions;patient derived xenograft model;patient oriented research;Patients;Peer Review;Peer Review Grants;Population;Population Sciences;Pre-Clinical Model;Prevention;Principal Investigator;Productivity;prognostic;programs;Publications;Publishing;Regulation;Research;Research Personnel;Resistance;Resource Sharing;response;Safety;Schools;Science;Scientist;self-renewal;Signal Pathway;Signal Transduction;Signaling Molecule;Site;Solid Neoplasm;stem;stem cells;Strategic Planning;success;System;Testing;therapy development;therapy resistant;Training;Translating;translational pipeline;translational potential;treatment response;tumor;tumorigenesis;United States National Institutes of Health;Universities;Utah;Work;Xenopus;Zebrafish

PROJECT_TITLE: Cell Response and Regulation (CRR)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Mental Health;Social Determinants of Health;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE This project will test an implementation strategy that seeks to align system, organization, and clinic leadership and strategies to implement and sustain an evidence-based practice (EBP) for substance use disorders. The Leadership and Organizational Change for Implementation - System Level (LOCI-SL) seeks to improve implementation leadership, climate, provider attitudes and behaviors, and EBP fidelity for enhanced client engagement in services and outcomes. LOCI-SL will be tested in a large, statewide, integrated mental health and addiction service system through clinics in community mental health centers.

PI_NAMEs: AARONS, GREGORY  (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: addiction;Address;Adolescent;Affect;American;Area;Attitude;Behavior;Child Abuse;Client;Climate;Clinic;Cognitive Therapy;Collaborations;Communities;community academic partnership;Community Mental Health Centers;Competence;Complex;cost;Cost Analysis;cost estimate;Crime;Data;Data Analyses;Decision Making;Development;Domestic Violence;evidence base;Evidence based practice;experience;Exploration, Preparation, Implementation, and Sustainment;Failure;Family;Funding;Future;Goals;Health;implementation context;implementation cost;implementation efforts;implementation framework;implementation outcomes;implementation research;implementation science;implementation strategy;implementation/effectiveness;improved;Indiana;Individual;innovation;Intervention;Justice;Knowledge;Leadership;Legal system;Maps;meetings;Mental Health;Methods;Modeling;Motivation;motivational enhancement therapy;National Institute of Drug Abuse;Needs Assessment;Neighborhood Health Center;Opioid;Organizational Change;organizational climate;Outcome;Pathway interactions;Policies;Population;Prevention;Process;Productivity;Provider;provider behavior;Public Health;Public Sector;Research;Research Personnel;Resources;scale up;Schools;service delivery;Services;Shapes;Site;Substance Use Disorder;System;Testing;theories;Time;Translational Research;United States National Institutes of Health;Work

PROJECT_TITLE: Statewide System and Organizational Strategy for Evidence-Based Practice Implementation and Sustainment in Substance Use Disorder Treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-J(04)]


NIH_SPENDING_CATS: Cancer;Precision Medicine

PI_NAMEs: MCMAHON, MARTIN  (contact)

PROJECT_TERMS: anti-cancer research;Applications Grants;Area;Basic Science;bench to bedside;Biochemistry;biomarker discovery;cancer care;cancer cell;Cancer Center Support Grant;Cancer Diagnostics;Cancer Patient;cancer therapy;cancer type;Catchment Area;Cellular biology;chemotherapy;Clinic;Clinical;clinical implementation;clinical infrastructure;clinical practice;Clinical Research;clinical translation;Clinical Trials;Collaborations;college;Combined Modality Therapy;Conduct Clinical Trials;Correlative Study;Development;Diagnosis;Diagnostic;Disease;Disease Management;Disease Outcome;Doctor of Philosophy;Drug resistance;drug sensitivity;effectiveness evaluation;Faculty;first-in-human;Fostering;Funding;Goals;Grant;Growth;Home;Human;Immunooncology;improved;improved outcome;Individual;Industry;innovation;Institution;interest;International;Intervention;Investigational Therapies;investigator-initiated trial;Investments;Laboratories;Malignant Neoplasms;Measures;member;Mission;Molecular Biology;National Cancer Institute;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Paper;Pathway interactions;Patient-Focused Outcomes;Patients;Peer Review;pharmacologic;Pharmacology;Physicians;Physiology;Pilot Projects;Population;pre-clinical;pre-clinical research;Principal Investigator;Prognosis;prognostic;programs;Publications;Publishing;Radiation therapy;recruit;Research;research clinical testing;Research Institute;Research Personnel;Research Project Grants;Research Support;Resistance;Resources;response biomarker;Schools;Science;Scientist;senior faculty;Specimen;Strategic vision;Stream;success;Testing;Therapeutic;therapy outcome;therapy resistant;Translating;Translational Research;translational scientist;Translations;Treatment outcome;treatment trial;tumor microenvironment;United States;Universities;Utah;Vision

PROJECT_TITLE: Experimental Therapeutics (ET)


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHICAGO

ORG_DEPT: UROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The proposed research investigates different types of non-canonical molecular events expressed in RNA that can change the sequence of genes and spark abnormal disease-causing proteins. By developing innovative computer algorithms for analyzing population-scale datasets, we will systematically detect these previously unexplored events and highlight their functional relevance to health and disease. We will distribute the developed tools in open-source software packages to benefit the scientific and biomedical communities.

PI_NAMEs: YANG, RENDONG  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Algorithms;Alternative Splicing;Basic Science;Catalogs;cell type;Communities;Complex;Computational algorithm;computer framework;Computer software;Data;Data Set;Dedications;Development;Disease;Event;exon skipping;Genes;Genetic;genome sequencing;Genomic medicine;Genotype-Tissue Expression Project;Goals;Health;human disease;improved;innovation;Introns;Modeling;Molecular;Multiomic Data;novel;novel therapeutic intervention;open source;Pattern;Population;Prevalence;programs;Proteins;proteogenomics;Reporting;Research;RNA;RNA Splicing;sequencing platform;Series;Site;Technology;The Cancer Genome Atlas;tool;Transcript;transcriptome;Variant;whole genome;Work

PROJECT_TITLE: Computational approaches to delineate non-canonical splicing events

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Rural Health;Social Determinants of Health

PI_NAMEs: CANNING, DAVID J (contact)

PROJECT_TERMS: Africa;African;Age Years;Aging;Algorithms;Asian;Biological Assay;Biological Markers;biomarker validation;Blood;Calibration;Cognition;Cognitive;cognitive ability;cognitive function;cognitive testing;cohort;Collection;Color;Communities;comparative;Comparative Study;Complex;Consensus;Country;COVID-19 impact;Data;Data Collection;Data Set;Dementia;Diagnosis;Dryness;Education;Environment;experience;Family;Family health status;Family Study;follow-up;Future;Goals;Health;Health and Retirement Study;health care service utilization;health economics;health inequalities;Health Surveys;healthy aging;Household;Impaired cognition;improved;Income;Individual;innovation;insight;instrument;International;Labor Migrations;Language;Living Standards;Longitudinal cohort;Longitudinal Studies;Measurement;Measures;member;Mental Health;Methods;mild cognitive impairment;Neighborhoods;Network Infrastructure;Nonrespondent;Outcome;Patient Recruitments;Persons;Pilot Projects;Policy Making;Population;Population Group;Population Research;prediction algorithm;Prevalence;programs;Protocols documentation;Research;Research Personnel;response;Rural;rural area;Sampling;Selection Bias;Sister;Site;Socioeconomic Status;socioeconomics;South Africa;South African;Spottings;Surveys;Testing;therapy development

PROJECT_TITLE: Project 4 - HAALSI National


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

PI_NAMEs: MOONEY, KATHLEEN H (contact)

PROJECT_TERMS: Address;Area;behavior change;cancer care;Cancer Center Support Grant;Cancer Control;cancer diagnosis;cancer epidemiology;cancer genetics;cancer health disparity;cancer predisposition;cancer prevention;Cancer Prognosis;cancer risk;cancer therapy;care delivery;Catchment Area;Chemoprevention;Clinic;Clinical;clinical care;Clinical Chemoprevention;Clinical Research;Clinical Trials;Collaborations;college;Colorectal Cancer;Communication;Communities;community intervention;Development;Direct Costs;Discipline;Disease Outcome;Doctor of Philosophy;end of life;Environment;Extramural Activities;Family;frontier;Funding;gene discovery;Genealogy;Genetic;Genetic Predisposition Testing;Genetic Predisposition to Disease;Genomics;Genotype;Head and Neck Cancer;health disparity;high risk;implementation science;improved;improved outcome;Incidence;Individual;Infrastructure;innovation;interest;International;Intervention;Intervention Studies;Investments;Knowledge;Laboratories;Link;Malignant Neoplasms;Medical;member;Methodology;Minority;Mission;National Cancer Institute;Observational Study;Oncogenes;Oncology;Outcome;Outcome Study;patient oriented research;Patient Recruitments;Patients;Peer Review;Phenotype;Population;population based;Population Database;Population Sciences;precision oncology;prevent;Prevention;prevention clinical trial;Prevention Measures;Prevention Research;Prevention trial;Productivity;programs;Protocols documentation;Publications;Recording of previous events;Records;Recovery;Research;Research Design;Research Personnel;Resource Sharing;Risk;Risk Reduction;Risk Reduction Behavior;Rural;Schools;Science;success;survivorship;Susceptibility Gene;Testing;Translating;Translational Research;Translations;Treatment outcome;tumor initiation;Utah;Variant;Vision;Work

PROJECT_TITLE: Cancer Control and Population Sciences (CCPS)


PHR: Project Narrative Extracellular vesicles are shed by all cells in the body into the blood and so provide a unique opportunity for monitoring the tumor microenvironment with liquid biopsies. We propose developing an ultra-high-throughput droplet-based multiomic profiling platform, Vesicle Epitope Transcript sequencing (VET-seq), that can simultaneously resolve the surface proteome, internal proteins, and broad RNA spectrum with single vesicle resolution. The proposed technology will be of high value to the fundamental and clinical oncology communities.

PI_NAMEs: LU, YUE  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Address;Antibodies;antibody conjugate;assay development;Back;Bar Codes;Benchmarking;Biological;Biology;Blood;Blood Cells;cancer biomarkers;cancer cell;Cancer cell line;cancer drug resistance;Cancer Hospital;cancer recurrence;Cell Culture Techniques;Cell model;Cells;Characteristics;Clinical;Clinical Oncology;Clinical Trials Design;combinatorial;Community Clinical Oncology Program;Computational Biology;cost effective;Custom;Cytolysis;Data;Detection;detection limit;Development;Diagnostic;Diameter;Disease;DNA;Drug resistance;ds-DNA;Encapsulated;Epitopes;experimental study;extracellular vesicles;Genetic;Health Status;high dimensionality;High-Throughput Nucleotide Sequencing;Human;In Situ;indexing;Individual;innovation;insight;Investigation;Light;liquid biopsy;Malignant neoplasm of lung;Malignant Neoplasms;Medical Oncologist;Membrane;Messenger RNA;Methods;Microfluidic Microchips;MicroRNAs;Modeling;Modification;Molecular;Moloney Leukemia Virus;Monitor;multidisciplinary;multiple omics;Nanotechnology;Neoplasm Metastasis;Permeability;Plasma;Play;Poly(A) Tail;Polyadenylation;Primary Lesion;Proteins;Proteome;Protocols documentation;Reporting;Resolution;RNA;RNA-Directed DNA Polymerase;Role;sample fixation;Sampling;Scientist;Screening for cancer;Serum;Signal Transduction;single cell analysis;Site;Source;Specimen;Stains;statistics;Surface;Systems Biology;Technology;Therapeutic;Tissues;trafficking;Transcript;transcriptome;transcriptome sequencing;treatment response;tumor microenvironment;Universities;Untranslated RNA;Utah;Vesicle;Work

PROJECT_TITLE: Vesicle Epitope Transcript sequencing (VET-seq): Droplet-based Multiomic Profiling Platform for Single Vesicle Analysis


NIH_SPENDING_CATS: Cancer;Pediatric

PI_NAMEs: AYER, DONALD E (contact)

PROJECT_TERMS: Accreditation;anti-cancer research;Award;Basic Science;biomedical profession;Cancer Center;Cancer Center Support Grant;cancer education;cancer health disparity;Cancer Patient;cancer prevention;cancer risk;cancer therapy;career;Career Choice;career development;Caring;Catchment Area;Clinic;Clinical;clinical center;Clinical Sciences;community engagement;Complement;Dedications;design;Development;Development Plans;Discipline;Disease;Disparity;Doctor of Philosophy;Education;Educational Curriculum;Educational workshop;Ensure;Environment;experience;Exposure to;Extramural Activities;Faculty;Fellowship;Financial Support;Fostering;Funding;Future;Genetic Counseling;Geography;Goals;graduate medical education;graduate student;Grant;Health Occupations;Health Professional;high school;High School Student;Huntsman Cancer Institute at the University of Utah;Idaho;improved;Individual;Infrastructure;Interdisciplinary Education;Interdisciplinary Study;K-12 student;Knowledge;Leadership;Learning;Malignant Neoplasms;Medical;meetings;member;Mentors;Mentorship;Methods;minority trainee;Mission;Montana;multidisciplinary;National Cancer Institute;Nevada;next generation;North Dakota;Oncology Nurse;outreach;Pathway interactions;Patient Care;Patient Education;Patient-Focused Outcomes;Patients;Phase;Phenotype;Physicians;Population;Postdoctoral Fellow;pre-doctoral;Prevention;programs;psychosocial;public education;Publishing;Reporting;Research;research and development;Research Institute;Research Personnel;Research Project Grants;Residencies;Resources;Running;Rural;Science;Scientist;Series;Shapes;skills;South Dakota;Students;summer research;symposium;tenth grade;Training;training opportunity;Training Programs;Training Support;Translational Research;Travel;tumor;twelfth grade;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Utah;Work;Writing;Wyoming

PROJECT_TITLE: Cancer Research Career Enhancement and Related Activities