ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Emergency Care;Heart Disease;Nutrition;Obesity;Prevention;Sleep Research

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: NARRATIVE People who experience repeated bouts of circadian misalignment, such as shift workers, are at higher risk of developing cardiovascular disease and Type 2 diabetes compared to daytime workers; however, there have been few attempts to develop strategies to improve health in shift workers. Highly controlled inpatient studies suggest that a circadian-based eating strategy in which energy intake is restricted to the daytime period during circadian misalignment improves markers of cardiometabolic health. The goal of this project is to translate this strategy of timed eating to a population of free-living shift workers to identify a non-pharmacological strategy that could mitigate cardiometabolic disease risk in this population, which represents more than 25% of the US workforce.

PI_NAMEs: BROUSSARD, JOSIANE  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Acute;Adult;awake;Behavior;Biological;Biology;Biopsy;blood glucose regulation;Blood Pressure;blood pressure elevation;blood pressure reduction;Blood specimen;Blood Vessels;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Ceramides;Chronic;circadian;Circadian desynchrony;Circadian Dysregulation;circulating biomarkers;Circulation;Continuous Glucose Monitor;cost effective;Cross-Over Studies;Data;Development;Diastolic blood pressure;dietary;Diglycerides;Disease;disorder risk;Eating;Emergency medical service;endothelial dysfunction;Endothelin-1;Endothelium;energy balance;Energy Intake;Event;experience;fire fighter;Future;Glucose;Glucose Clamp;Goals;Health;Healthcare;high risk;Hospitals;Hour;Human;Hyperinsulinism;impaired driving performance;Impairment;improved;Individual;Inpatients;Insulin;Insulin Resistance;insulin sensitivity;insulin signaling;interstitial;Knowledge;Light;lipidomics;Lipids;manufacture;Mediating;Metabolic;Military Personnel;Modeling;Muscle;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;Nurses;Obesity;Outcome;Outpatients;Overweight;Paramedical Personnel;Participant;Persons;Physical activity;Plasma;Plasminogen Activator Inhibitor 1;Police;Polysomnography;Population;programs;Protein Analysis;Protein Isoforms;Protein Kinase C;Proto-Oncogene Proteins c-akt;Protocols documentation;Publishing;Randomized;reduced food intake;Risk;Risk Factors;Security;shift work;Sleep;Sleep disturbances;Testing;Thinness;Time;time use;Time-restricted feeding;Tissues;Translating;Transportation;Triglycerides;Vascular Endothelial Growth Factors;Vascular Endothelium;Western Blotting;Work

PROJECT_TITLE: Impact of circulating and tissue-specific lipids on vascular function and insulin sensitivity in chronic night shift workers

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE: Targeting dsRNA pattern recognition receptors (PRRs) in tumors represents a promising strategy to treat patients with melanoma and other tumor types. In this proposal we address gaps in knowledge that limit the translation of dsRNA PRR-targeting strategies, determining the effects of dsRNA sensing on T cells, evaluating the efficacy of targeting single versus multiple sensing pathways and identifying the tumors most likely to respond to therapy. If successful, this work will help define the rules that govern tumor and immune responses to dsRNA and advance novel therapeutic strategies that target RIG-I and ADAR1.

PI_NAMEs: ISHIZUKA, JEFFREY J. (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Abscopal effect;Acute;Address;Adenosine;adenosine deaminase;Adoptive Transfer;Advanced Development;Agonist;anti-cancer;anti-PD-1;Antigen-Presenting Cells;Antigens;cancer infiltrating T cells;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cell Death;Cell Physiology;cell type;Cells;Clinical;clinical sequencing;clinically actionable;Coculture Techniques;Cross Presentation;cytokine;Cytoplasm;Data;Dendritic Cells;Development;Double-Stranded RNA;effective therapy;efficacy evaluation;Enzymes;exhaustion;experience;experimental study;Flow Cytometry;Genes;Genetic;genetic signature;Human;Immune;immune cell infiltrate;immune checkpoint blockade;Immune response;Immunity;Immunotherapy;improved;In Vitro;in vivo;Inflammatory;Inosine;insight;Interferons;interleukin-15 receptor;Knowledge;Malignant Neoplasms;Melanoma;Melanoma Cell;Melanoma Tumor;mouse model;Mus;neoplastic cell;novel;novel therapeutic intervention;nucleic acid-based therapeutics;Pathway interactions;Patients;Pattern recognition receptor;potential biomarker;programs;Proliferating;recruit;Resistance;response;response biomarker;Sampling;sensor;Signal Transduction;single-cell RNA sequencing;Small Interfering RNA;small molecule;stem;stem cells;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic target;TNFSF6 gene;Translating;translational approach;Translations;treatment response;tumor;Tumor Antigens;Tumor Cell Line;tumor growth;Tumor Immunity;tumor microenvironment;Viral;Virus Diseases;Work

PROJECT_TITLE: Targeting dsRNA sensing and ADAR1 in melanoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 TIO-D (01)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Lymphatic Research;Regenerative Medicine

ORG_CITY: NEW YORK

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: NARRATIVE Notch signaling is fundamental to lymphatic growth, function, and homeostasis. We present data demonstrating unique functions for Dll4/Notch4 and Jag1/Notch4 signaling in lymphatic endothelial cell quiescence and regeneration in the skin and liver. These studies will aid us in understanding the lymphatic endothelial specific functions for Notch.

PI_NAMEs: SHAWBER, CARRIE J. (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Address;Adult;Adult women;Affect;Age;age effect;Blood;Blood Vessels;cell growth;Cell Proliferation;Cell surface;chemokine;clinical development;Clinical Trials;Coagulation Process;Collagen;cytokine;Data;Defect;density;Deposition;Dermal;Development;dietary;differential expression;Disease;Endothelium;Estrogens;Fatty acid glycerol esters;Female;Fibrin;Fibrosis;Gene Expression Profile;Genes;Genetic Transcription;Goals;Growth;Hepatic;Homeostasis;Human;human disease;immune cell infiltrate;Immune response;Immunotherapy;In Vitro;in vivo;Intestines;knock-down;Ligands;Link;Lipedema;Liver;Liver diseases;Liver Fibrosis;Locomotion;Lymphangiogenesis;Lymphatic;Lymphatic Capillaries;lymphatic development;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic Endothelium;lymphatic vasculature;lymphatic vessel;Macrophage;Maintenance;male;malformation;Malignant Neoplasms;Metabolic Diseases;Modeling;mouse model;mRNA sequencing;Mus;Natural regeneration;Neoplasm Metastasis;nonalcoholic steatohepatitis;notch protein;NOTCH1 gene;NOTCH4 gene;novel;Obesity;Organ;Organ Transplantation;Pathogenicity;Pathologic;Pathology;Pathway interactions;Pattern;Phenotype;postnatal;prenatal;Proliferating;Psoriasis;PTPRC gene;receptor;Regulation;response;Role;sex;Signal Transduction;Skin;stellate cell;subcutaneous;targeted treatment;Tissues;Transgenic Mice;Transgenic Model;Tumor Angiogenesis

PROJECT_TITLE: Notch Signaling in the Adult Lymphatic Vasculature

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative The AML1-ETO fusion protein causes acute leukemia in children and adults, and we have been studying the fundamental mechanisms that underlie its leukemia promoting ability. By combining biochemical approaches with biological and genomic data from human cell lines and mouse models, we have uncovered a range of oncogenic functions promoted by AML1-ETO. We are focused on targeting the co-factors required for AML1-ETO oncogenic functions in order to develop effective targeted approaches to this disease.

PI_NAMEs: NIMER, STEPHEN D. (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acetylation;Acute leukemia;Acute Myelocytic Leukemia;Adult;Affect;AML1-ETO fusion protein;Behavior;Binding;Biochemical;Biological;Biology;Bromodomain;chemotherapy;Childhood Leukemia;Chromatin;cofactor;Complex;Data;Development;Disease;DNA;Enhancers;EP300 gene;ETS Family Protein;ETV6 gene;Event;experience;FLT3 gene;Gene Activation;Gene Expression;gene repression;Genes;Genetic Transcription;genomic data;Growth;hematopoietic stem cell self-renewal;Human Cell Line;Impairment;inhibitor;leukemia;leukemogenesis;Link;LYL1 gene;Lysine;Maintenance;Malignant Neoplasms;Mediating;MLL-rearranged leukemia;Molecular;mouse model;Mutate;Myelogenous;novel;Oncogenic;Pathway interactions;Patients;Proliferating;Proteins;Proto-Oncogene Proteins c-akt;Recurrent disease;Refractory Disease;Regulation;Repression;Repressor Proteins;Role;RUNX1 gene;self-renewal;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Signaling Molecule;stem cell self renewal;t(8;21) acute myeloid leukemia;t(8;21)(q22;q22);TAF1 gene;TAF12 gene;targeted treatment;Testing;transcription factor;treatment strategy;Up-Regulation

PROJECT_TITLE: Targeted therapy for t(8;21)+ AML

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: GALVESTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PUBLIC HEALTH RELEVANCE The synaptic organizers, neurexins and their partners, play a central role in severe neuropsychiatric disorders including autism spectrum disorder and schizophrenia. These proteins constitute a suite of molecules that regulate synapse development, either by forming trans-synaptic bridges or by dynamically regulating these bridges. Elucidating the mechanisms of these molecules will reveal how they guide synapse development, shape neural circuits and regulate circuit plasticity, as also will lay the foundation to investigate highly innovative, mechanism-based therapies that target specific synapses and select circuits to ameliorate CNS disorders.

PI_NAMEs: RUDENKO, GABRIELLE  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: 3-Dimensional;Address;Adhesives;Animal Model;Astrocytes;autism spectrum disorder;base;Behavior;Binding;Biochemical;Biochemistry;Biological;Biological Assay;Biophysics;Cells;Central Nervous System Diseases;Code;Cognition;Communication;Defect;Development;Disease;electron tomography;Family;Family member;flexibility;Foundations;Funding;Genetic;Goals;Health;hevin;Human;Image;in vivo;innovation;insight;Intellectual functioning disability;Lesion;Ligands;Mediating;Methodology;Modeling;Molds;Molecular;Molecular Conformation;Nature;Nervous System Disorder;neural circuit;Neurons;neuropsychiatric disorder;Pathology;Pharmaceutical Preparations;Play;Positioning Attribute;postsynaptic;presynaptic;Process;Protein Conformation;Proteins;prototype;public health relevance;recruit;Regulation;Role;scaffold;Schizophrenia;severe mental illness;Shapes;structural biology;Synapses;Synaptic Cleft;synaptic function;Synaptic Membranes;synaptogenesis;synergism;targeted treatment;Techniques;Therapeutic;three dimensional structure;Translating;Work

PROJECT_TITLE: Synaptic Organizers: Dynamic Regulation of Trans-synaptic Bridges

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ORG_CITY: Columbus

ORG_DEPT: SURGERY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Pulmonary hypertension affects the right ventricle of the heart, but there are no therapies targeted at this ventricle. The research in this proposal will contribute to fundamental knowledge of the right ventricle of the heart and have direct application towards the development of novel therapies for PH and other diseases affecting the right ventricle.

PI_NAMEs: GORR, MATTHEW WILLIAM (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Affect;Animal Model;antagonist;Behavior;Binding;Biology;Blood Volume;Cardiac;Cell Physiology;Cells;Cellular biology;Chemicals;Clinical;Coculture Techniques;coronary fibrosis;Data;density;design;Development;Dilatation - action;direct application;Disease;Disparate;Disparity;experimental study;Failure;Fibroblasts;Fibrosis;Flow Cytometry;Functional disorder;Gene Expression;Genes;Goals;Heart Ventricle;human subject;Hypertrophy;Hypoxia;Immune;Immune response;Immune signaling;Immune Targeting;Immunohistochemistry;In Situ;In Vitro;in vivo;individualized medicine;Inflammation Mediators;Inflammatory;inhibitor;Innate Immune Response;Intervention;Knowledge;Lead;Left ventricular structure;Leukocytes;Lung;Macrophage;Measures;Mediating;Mediator;Medical;Metabolic;Metabolism;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;novel;novel therapeutic intervention;novel therapeutics;Obstruction;Outcome;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Physiology;Population;pressure;Process;Production;Proliferating;pulmonary arterial hypertension;Pulmonary artery structure;Pulmonary Hypertension;Rattus;Research;response;Right Ventricular Dysfunction;right ventricular failure;Right Ventricular Hypertrophy;right ventricular remodeling;Right ventricular structure;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Sprague-Dawley Rats;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;transcriptomics;Transplantation;treatment response;Validation;Vascular Endothelial Growth Factors;Vascular resistance;Western Blotting;Work

PROJECT_TITLE: Right ventricle remodeling in pulmonary hypertension

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Clinical Research;Heart Disease;Neurosciences;Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Neuroprognostication of unresponsive survivors following cardiac arrest, crucial to providing closure to families and to guide allocation of scarce critical care resources, is challenging. Prior models of prognostication arose from studies plagued by the self-fulfilling prophecy bias introduced by the withdrawal of life support due to perceived poor neurological prognosis, and more accurate models of prognostication are needed, with greater understanding of the usefulness and limitations of commonly utilized tools in the present day. We propose a joint study between the US and Brazil, where the practice of withdrawal of life support is virtually nonexistent, and will capitalize on the expertise of experienced investigators and collaborators utilizing the unbiased population in Brazil.

PI_NAMEs: GREER, DAVID MATTHEW (contact);SAMPAIO SILVA, GISELE

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Accounting;Address;Affect;Age;American Heart Association;Assessment tool;Biochemical Markers;Blinded;Brazil;Cardiac Volume;Cardiopulmonary Resuscitation;care costs;Caring;Cause of Death;censorship;Cessation of life;Characteristics;Clinical;Clinical Trials;cohort;Collaborations;Coma;comorbidity;Conscious;cooperative study;Critical Care;Data;demographics;disability;Electroencephalography;Electrophysiology (science);Enrollment;Environment;experience;Exposure to;Family;Foundations;functional independence;functional outcomes;Future;Gender;Goals;Guidelines;Heart Arrest;heart rhythm;Hospital complications;Hour;Hypoxic-Ischemic Brain Injury;improved;Individual;injury burden;innovation;Intensive Care;International;Joints;Knowledge;Life;life-sustaining therapy;Mediation;Medical;Methods;mild cognitive impairment;Modeling;Modernization;mortality;Multicenter Studies;multimodality;Natural History;Nature;neuroimaging;Neurologic;Neurologic Examination;Neurological outcome;neurological recovery;Neuroprotective Agents;Outcome;outcome prediction;Patients;Performance;Persistent Vegetative State;Physicians;Population;predictive modeling;predictive tools;premature;Prognosis;prognostic;prognostic algorithm;prognostic assays;prognostic tool;prognostic value;prognostication;prospective;Publications;Race;Recommendation;Recovery;Research Personnel;Resources;Resuscitation;Secondary to;Severities;Shock;Site;Standardization;State Hospitals;Survivors;Testing;Therapeutic;Time;tool;Uncertainty;virtual;Weight;Withdrawal

PROJECT_TITLE: Addressing an inherent bias in neuroprognostication: A collaboration between the US and Brazil to reduce the impact of Self-fulfilling Prophecy in cardiac ARrEst (SPARE)

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Biotechnology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative Despite extensive clinical testing, mesenchymal stem/stromal cell (MSC)-based therapies continue to yield suboptimal patient outcomes due to knowledge gaps in quality attributes that confer therapeutic efficacy, which explains why most clinical studies produce MSCs using similar donor selection and manufacturing processes to treat medically unrelated diseases. To address this problem, we developed a CLinical Indications Prediction (CLIP) scale that predicts inter-donor differences in MSC potency for a range of clinically relevant activities. Building on this discovery, in this proposal we propose to use the CLIP scale to interrogate how donor selection and academic and industry-based manufacturing platforms impact MSC product potency and use this information to produce products of defined potency that are tailored for specific disease indications to enhance their efficacy.

PI_NAMEs: PHINNEY, DONALD G (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Acute Lung Injury;Address;Adopted;Animal Model;Anti-Inflammatory Agents;Binding;Biogenesis;Biological Assay;Biological Markers;Biological Products;biomarker identification;Cell Therapy;Cells;Clinical;clinical application;Clinical Research;Clinical Trials;clinically relevant;cohort;Cyclic GMP;Data;Disease;Donor Selection;efficacy outcomes;Epigenetic Process;Equation;Exhibits;Exposure to;extracellular vesicles;FGF2 gene;Funding;Genes;Genomics;Goals;Growth;histone modification;Human;human disease;immunoregulation;improved;improved outcome;Industry;Industry Standard;Insulin-Dependent Diabetes Mellitus;Interferon Type II;Interleukin-1;Investigation;Knowledge;Laboratories;large scale production;Licensing;Link;manufacture;manufacturing process;matrigel;Medical;Mesenchymal;Mesenchymal Stem Cells;Methods;Methylation;Monitor;Outcome;paracrine;patient population;patient stratification;Patient-Focused Outcomes;Patients;Population;population based;potency testing;pre-clinical;Pre-Clinical Model;Process;Production;progenitor;promoter;protein expression;research clinical testing;RNA;Scheme;small molecule;stem;Stromal Cells;Testing;Therapeutic;TNF gene;Treatment Efficacy;TSG-6 protein;TWIST1 gene

PROJECT_TITLE: A Clinical Indications Prediction (CLIP) Scale for Human Mesenchymal Stem Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (80)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: NEWARK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: NEW JERSEY INSTITUTE OF TECHNOLOGY

ORG_STATE: NJ

PHR: We propose that convergent effects of endogenous brain neuromodulatory chemicals may be essential to limiting inter-individual variability of neural systems and shaping consistent neural activity. We develop a mathematical framework for neural output variability and use the crustacean stomatogastric system, one of the best-understood neural circuits for studying neuromodulation, to experimentally explore this hypothesis. Our work will provide insight into general principles of how the nervous system produces reliable activity in face of significant inter-individual variability.

PI_NAMEs: BUCHER, DIRK MARTIN;NADIM, FARZAN  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Amines;Animals;Behavior;Behavioral;Binding;Biological Models;biophysical techniques;Brain;cell type;Characteristics;Chemicals;Collaborations;Computer Models;Crab stomatogastric ganglion;Crustacea;Dopamine;dynamic system;Electrophysiology (science);Elements;experimental study;Face;flexibility;Frequencies;Grant;Health;Individual;insight;inter-individual variation;Lead;mathematical analysis;Mathematics;Measures;Mediating;Mental disorders;Methods;Modeling;Nervous System;Nervous System Disorder;Nervous System Physiology;neural;neural circuit;Neuromodulator;Neuromodulator Receptors;neuronal excitability;Neurons;Neuropeptides;neuroregulation;operation;Output;Peptides;Phase;Play;Process;Production;Property;Refractory;response;Role;Second Messenger Systems;Shapes;Source;Statistical Distributions;Synapses;System;Systems Analysis;Temperature;Testing;theories;Time;Work

PROJECT_TITLE: Modulation of Neuronal Oscillations

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Biomedical Imaging;Bipolar Disorder;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Rehabilitation;Schizophrenia;Serious Mental Illness

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Cognitive impairments in psychotic disorders are among the strongest predictors of poor functional outcomes in patients. We have identified and replicated a novel brain circuit linked to multiple cognitive deficits in psychosis. We will determine if this circuit can be engaged using non-invasive neuromodulation so that it can be used as a treatment target for clinical trials.

PI_NAMEs: BRADY, ROSCOE O. (contact);LEWANDOWSKI, KATHRYN EVE

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Acute;Affect;Animals;Biological Markers;Bipolar Disorder;Brain;candidate identification;Cerebellar Cortex;Cerebellum;Clinical Trials;Cognition;Cognitive;cognitive change;Cognitive deficits;cognitive function;cognitive performance;cognitive testing;Data;Diagnosis;disability;Disabling;Equipment;Functional disorder;Functional Magnetic Resonance Imaging;functional outcomes;Funding;Future;Goals;Hallucinations;high risk;Human;Image;Impaired cognition;improved;Individual;Intervention;Intervention Trial;Link;National Institute of Mental Health;Nature;neural circuit;Neurobehavioral Manifestations;neuroimaging;neuroregulation;novel;Pathology;Patient Recruitments;Patients;Performance;Persons;Pharmaceutical Preparations;Population;processing speed;programs;Progress Reports;Protocols documentation;Psychoses;Psychotic Disorders;psychotic symptoms;Quality of life;Refractory;Research;Resources;Schizophrenia;serial imaging;Short-Term Memory;Symptoms;Task Performances;Techniques;Testing;therapeutic target;Time;trait;Transcranial magnetic stimulation;Translations;Variant

PROJECT_TITLE: Cerebellar Modulation of Cognition in Psychosis

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Disability Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Physical Activity;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Social Determinants of Health

ORG_CITY: LONDON

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY COLLEGE LONDON

ORG_ZIPCODE: WC1E 6BT

PHR: The increase in longevity of the population has stalled in recent years, while socioeconomic inequalities in health and prosperity persist into older ages both in the UK and the USA. The multidisciplinary English Longitudinal Study of Ageing collects longitudinal data from a large population sample to help us understand the determinants and consequences of these issues for quality of life, cognitive impairment including Alzheimer’s Disease, and healthy aging. Repeated measures of health and disability, economic circumstances, social participation, cognitive and physical function, wellbeing, biology and genetics are relevant both to public policy and scientific investigations, and comparisons with the Health and Retirement Study provide insight into the drivers of these processes in the USA and England.

PI_NAMEs: STEPTOE, ANDREW  (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Accelerometer;Activities of Daily Living;Address;Aging;aging population;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;Biological Factors;Biological Markers;Biology;Caring;Cell Aging;climate change;Cognition;Cognitive;cognitive function;cognitive testing;cohort;Collaborations;Consumption;cost;Cost Savings;Country;COVID-19 impact;COVID-19 mortality;COVID-19 pandemic;Data;Data Collection;data registry;Data Set;Dementia;dementia risk;digital;disability;Eating;Economics;Employment;England;Ensure;Epidemiology;ethnic minority;Event;expectation;experience;Family health status;Funding;Genetic;Geriatrics;Government;Great Britain;Health;Health and Retirement Study;health inequalities;Healthcare;healthy aging;Hearing;Hearing Tests;Housing;human old age (65+);Impaired cognition;improved;Incidence;Income;informal caregiving;Infrastructure;innovation;insight;International;Internet;Interview;Investigation;journal article;life history;Link;Long COVID;Longevity;Longitudinal Studies;Marketing;Measures;Mental Health;Methodology;Minority;Minority Men;Minority Women;Monitor;multidisciplinary;Neuropsychology;Nutrition Assessment;Older Population;Participant;Pattern;Pensions;Personal Satisfaction;Persons;Physical activity;Physical assessment;physical conditioning;Physical Function;Physical Performance;Physiological;Policies;Pollution;Population;Population Research;Prevalence;Primary Care;Process;Proteomics;Protocols documentation;Psychosocial Factor;Public Policy;Publishing;Quality of life;Records;recruit;Research;Research Personnel;Resources;Respondent;Retirement;Risk;Sampling;SARS-CoV-2 infection;Secure;Services;Sister;Sleep;social;social disparities;social engagement;Social isolation;Social Network;Social Sciences;socioeconomic disparity;Socioeconomic Status;Survey Methodology;Surveys;Telephone;United States National Institutes of Health;Visiting Nurse;Work

PROJECT_TITLE: English Longitudinal Study of Ageing - Renewal 2024

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: ES

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: NUTRITION

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE The proposed studies will (1) determine the evolution of genetic pathways altered as manganese (Mn) exposure extends from acute to chronic, and whether any such effects are persistent after cessation of chronic Mn overload, (2) evaluate the concurrent and persistent functional consequences of acute versus chronic Mn exposures and the influence of neural cell type, neurotransmitter-type, and genetic sex on the magnitude versus types of genetic pathways and functional outcomes altered, and (3) explore the mechanistic basis of chronic/persistent Mn neurotoxicity phenotypes via metabolic analysis, with pharmacological and genetic manipulation of signaling and metabolic pathways in C. elegans and hiPSC neural model systems. Our highly interactive experimental design brings innovative and complementary expertise to assess shared genetic networks of Mn-induced chronic neurotoxicity with translation from C. elegans to humans. We test the hypothesis that chronic Mn neurotoxicity is caused by a response to the impact of acute elevated Mn on neuronal cell signaling systems for which Mn normally acts as an essential co-factor.

PI_NAMEs: ASCHNER, MICHAEL ;BOWMAN, AARON B (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Acute;Address;Adverse effects;Age;aging brain;Astrocytes;behavioral outcome;behavioral response;Biological;Biological Models;Caenorhabditis elegans;cell cortex;Cell Death;cell type;Cells;Central Nervous System;Chronic;cofactor;Complex;cytotoxic;Data;design;dimension reduction;Dose;Environmental Exposure;Enzymes;Experimental Designs;Experimental Models;extracellular;functional outcomes;Funding;Gene Modified;Genetic;Genetic Epistasis;genetic evolution;genetic manipulation;genotypic sex;Health;healthy aging;Human;human induced pluripotent stem cells;in silico;in vitro Model;in vivo Model;Individual;innovation;inorganic phosphate;insight;Insulin;Intoxication;Investigation;Knowledge;Life;Link;Manganese;Measurement;Metabolic;Metabolic Pathway;Modeling;Morbidity - disease rate;nerve stem cell;Nervous System Disorder;Neurologic;Neurological outcome;Neurons;neurotoxicity;Neurotransmitters;Nutritional;Pathologic;Pathway Analysis;Pathway interactions;pharmacologic;Phenotype;Phosphotransferases;Population;Proto-Oncogene Proteins c-akt;Reporting;Research;response;Risk;Role;sex;Signal Pathway;Signal Transduction;Sirtuins;small molecule;Somatomedins;System;Testing;Toxic effect;TP53 gene;Transgenic Organisms;Translations

PROJECT_TITLE: Mechanisms of Manganese Neurotoxicity

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Childhood Injury;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Unintentional Childhood Injury

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Narrative: Neonatal hypoxic ischemic (HI) injury causes significant mortality and morbidity, and the only effective treatment is hypothermia. We will develop in vivo magnetic resonance imaging techniques, together with other imaging modalities, to assess tissue injury and survival after HI using a well-established mouse model of neonatal HI injury. The proposed techniques can potentially shed light on the mechanisms of HI injury and therapeutic hypothermia.

PI_NAMEs: NORTHINGTON, FRANCES J;ZHANG, JIANGYANG  (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: accurate diagnosis;Acute;Adult;Affect;Animal Model;Apoptosis;Axon;Brain;Brain Hypoxia-Ischemia;Cell Death;Cells;cellular pathology;Cessation of life;Clinic;Clinical;Correlation Studies;critical period;Data;design;Developed Countries;Development;diagnostic biomarker;Diffusion;Diffusion Magnetic Resonance Imaging;Edema;effective intervention;effective therapy;Event;extracellular;Extracellular Space;Future;gray matter;Histologic;Histology;Hour;Hybrids;hypoxic ischemic injury;Hypoxic-Ischemic Brain Injury;Image;Imaging Device;imaging modality;Imaging Techniques;improved;in vivo;in-vivo diagnostics;Infant;information gathering;Injury;interest;Intervention;ischemic injury;Knowledge;Light;Lipids;Magnetic Resonance Imaging;Maps;mass spectrometric imaging;Measurement;Measures;Metabolic;Methods;mitochondrial dysfunction;Modeling;Monitor;Morbidity - disease rate;mortality;mouse model;Mus;Myelin;natural hypothermia;Necrosis;neonatal brain;neonatal hypoxic-ischemic brain injury;neonatal mice;nerve injury;Neurodevelopmental Disability;Neurological outcome;Neurons;neuroprotection;Newborn Infant;non-invasive monitor;novel;novel imaging technique;Outcome;Pathogenesis;Pathologic;Pathology;Pattern;Physics;Process;regenerative therapy;Regional Anatomy;repaired;Reporting;Research;Severities;Signal Transduction;spatiotemporal;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;standard of care;Structure;Swelling;Techniques;Therapeutic;Therapeutic Effect;Therapeutic Intervention;Time;tissue injury;Tissue Survival;Tissues;tool;translational potential;treatment response;vasogenic edema;Water;white matter

PROJECT_TITLE: Imaging Neonatal Hypoxic Ischemic Injury

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Services;Human Genome;Lung;Lung Cancer;Prevention;Primary Health Care;Tobacco;Tobacco Smoke and Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Narrative Lung cancer is the leading cause of cancer death in the US, and while annual screening with low-dose CT (LDCT) is recommended for high-risk individuals, the high false-positive rates remain a major challenge. We propose to use existing blood samples collected during the National Lung Screening Trial (NLST) to evaluate whether newly identified DNA methylation markers can be used in a clinical setting to improve the selection of high-risk candidates for screening with LDCT.

PI_NAMEs: MICHAUD, DOMINIQUE S. (contact)

PROGRAM_OFFICER_NAME: CARRICK, DANIELLE M

PROJECT_TERMS: Accounting;Address;Adult;Advisory Committees;Age;Age Years;aged;American College of Radiology Imaging Network;arm;biobank;Biological;Biological Markers;biomarker identification;Biometry;Blood;Blood specimen;cancer epidemiology;Cancer Etiology;cancer risk;Categories;Cells;Cessation of life;Classification;Clinical;clinical care;Complement;computed tomography screening;cost;Diagnosis;Diagnostic;disparity reduction;DNA;DNA Methylation;Dose;Eligibility Determination;epigenetic marker;Epigenetic Process;epigenome;follow-up;Genomic Segment;Goals;H19 gene;high risk;high risk population;Immune;improved;Incidence;Individual;Inequality;Investigation;Letters;Leukocytes;Life Cycle Stages;Link;low dose computed tomography;low-dose spiral CT;Lung;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Measures;men;Methods;Methylation;methylation biomarker;Minority;Modeling;multidisciplinary;Newly Diagnosed;Obesity;Participant;Patient risk;Patient Self-Report;Performance;peripheral blood;Radiation exposure;randomized trial;Recommendation;Recording of previous events;Research;Resources;Risk;Risk Factors;risk prediction;risk stratification;routine screening;RUNX3 gene;sample archive;Sampling;Scanning;screening;Screening procedure;Screening Result;sex;Smoke;Smoker;Smoking;Smoking History;smoking prevalence;Smoking Status;Spiral Computed Tomography;Testing;Thoracic Radiography;Time;Training;translational potential;Tumor Tissue;United States Preventative Services Task Force;Update;Visit;Woman

PROJECT_TITLE: Improving risk stratification for lung cancer screening using peripheral blood leukocyte DNA methylation: an investigation in the National Lung Screening Trial (NLST)

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: TYLER

ORG_NAME: UNIVERSITY OF TEXAS HLTH CTR AT TYLER

PHR: Project Narrative Vascular smooth muscle cell (VSMC) phenotypic modulation, a phenotypic switch from a differentiated contractile phenotype to a proliferative phenotype, contributes to vascular remodeling and the development of diverse vascular diseases such as atherosclerosis, hypertension, and restenosis following angioplasty. We have uncovered a novel role of Runt-related transcription factor 3 (RUNX3) in VSMC phenotypic modulation and proliferation, implicating it in the development of vascular injury-related cardiovascular diseases. The proposed studies will shed new lights on the pathogenesis of neointima formation and vascular remodeling, which may ultimately lead to the identification of novel targets for the therapeutic treatment of cardiovascular diseases related to vascular remodeling.

PI_NAMEs: GUO, XIA  (contact)

PROJECT_TERMS: Actins;acute myeloid leukemia 1 protein;Adult;Affect;Aneurysm;Angioplasty;Aorta;Arteries;Atherosclerosis;Attenuated;B cell differentiation;beta catenin;Binding;Blood Vessels;c-myc Genes;C57BL/6 Mouse;calponin;Cardiovascular Diseases;Carotid Arteries;Carotid Artery Injuries;Cell Proliferation;cell type;Common carotid artery;Coronary artery;Data;Development;Down-Regulation;Endothelial Cells;Endothelium;Family;Gene Expression;Genes;Genetic Markers;Genetic Transcription;glycogen synthase kinase 3 beta;Hematopoietic System;Human;Hypertension;In Vitro;in vivo;Inflammatory;injured;Injury;Intervention;knock-down;Knockout Mice;Knowledge;Left;Lesion;Ligation;Malignant Neoplasms;Mediating;Mesenchymal;migration;Molecular;Mus;Myelogenous;MYH11 gene;myocardin;neointima formation;new therapeutic target;novel;novel therapeutics;Oncogenes;Outcome;overexpression;Pathogenesis;Pathway interactions;Phenotype;Phosphorylation;Phosphorylation Inhibition;platelet-derived growth factor BB;Play;prevent;Proliferating;promoter;Rattus;Regulation;Regulator Genes;Reporting;Research;restenosis;Role;RUNX3 gene;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;Stenosis;Testing;transcription factor;Transcription Factor 3;Transcriptional Activation;Tumor Suppressor Proteins;Tunica Intima;Tunica Media;Vascular Diseases;vascular injury;Vascular remodeling;Vascular Smooth Muscle;vascular smooth muscle cell proliferation;Vein graft

PROJECT_TITLE: RUNX3 in Vascular Wall Remodeling


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: Newark

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Tuberculosis is a bacterial infectious disease that causes more global death than any other bacterial infection. This proposal investigates how tuberculosis-causing bacteria use phosphoarginine protein modifications to survive stress conditions. Our findings will reveal new information on the biology of these important bacterial pathogens, and will support efforts to develop new antibiotics to combat drug-resistant tuberculosis infections.

PI_NAMEs: SCHMITZ, KARL ROBERT (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Acute;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Arginine;Automobile Driving;Bacillus subtilis;Bacteria;Bacterial Infections;Binding;Binding Sites;Biochemical;biological adaptation to stress;Biological Assay;Biology;biophysical techniques;Cellular Stress;Cessation of life;Clinical;combat;Communicable Diseases;cryptic protein;Data;Distant;DNA;Drug resistance;Drug resistance in tuberculosis;Effectiveness;endopeptidase Clp;Enzymes;Excision;Future;genetic regulatory protein;Genus Mycobacterium;Growth;improved;In Vitro;Link;link protein;Methods;misfolded protein;Modeling;Modern Medicine;Modification;Molecular Conformation;Molecular Target;mortality;mycobacterial;Mycobacterium tuberculosis;novel;novel therapeutics;Outcome;pathogen;pathogenic bacteria;Pathway interactions;Peptide Hydrolases;Pharmaceutical Preparations;phospho-L-arginine;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Physiology;Post-Translational Protein Processing;programs;Proteins;Proteolysis;proteotoxicity;Quality Control;Regulation;Reporting;Research;response;Role;Signal Transduction;Starvation;Stress;stress tolerance;targeted treatment;Testing;Tuberculosis;Work

PROJECT_TITLE: Phosphoarginine-linked protein quality control and stress responses in mycobacteria

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: RIVERSIDE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

ORG_STATE: CA

PHR: Project Narrative The proposed research is relevant to public health because the discovery of the basic mechanisms of organellar gene expression is ultimately expected to increase understanding of how misregulation of mitochondrial gene expression leads to human diseases such as cancer. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to developing fundamental knowledge that will help to reduce the burdens of human disability.

PI_NAMEs: CHEN, MENG  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Arabidopsis;Bacteriophages;BHLH Protein;Biochemical;Biochemistry;Bioenergetics;Biogenesis;Biological Assay;Cell Nucleus;Cellular biology;Chloroplasts;Communication;Complex;Coupled;Data;disability;Dissection;DNA-Directed RNA Polymerase;Eukaryota;Event;Family;Gene Expression;gene product;Genes;Genetic;genetic approach;Genetic Models;Genetic study;Genetic Transcription;Genome;Genomic approach;Goals;Heterodimerization;Homeostasis;Human;human disease;Human Pathology;innovation;insight;Knowledge;Laboratories;Learning;Light;Malignant Neoplasms;Mediating;Mission;Mitochondria;Modeling;Molecular;Molecular Genetics;novel;Nuclear;Organelles;Organism;Outcome;Photoreceptors;Photosynthesis;phyB phytochrome;Phytochrome;Plants;Plastids;programs;promoter;protein complex;Proteins;Public Health;recruit;Regulation;Repression;Research;Role;Signal Pathway;Signal Transduction;System;Transcriptional Regulation;United States National Institutes of Health;Work

PROJECT_TITLE: Genetic and biochemical dissection of anterograde signaling for controlling plastid transcription

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE To eradicate the Hepatitis C epidemic, a dramatic shift in diagnostics methodology is needed. The current paradigm, which relies on lab-based tests, requires multiple visits with a patient because of the latency between sample collection and result. We aim to develop a system that is rapid, equipment-free, and easy-to- use, enabling a patient to receive a Hepatitis C viral test result within a single visit.

PI_NAMEs: WHITE, IAN M (contact)

PROGRAM_OFFICER_NAME: DYALL, JULIE

PROJECT_TERMS: Address;Alkanes;Automation;Biological Assay;Blood;Blood capillaries;Blood specimen;Bypass;Clinic;Clinical;Cold Chains;Collection;Color;cost;Cytolysis;design;Diagnosis;Diagnostic;diagnostic strategy;diagnostic technologies;DNA amplification;Epidemic;Equipment;Freeze Drying;Genomics;Genotype;Geometry;Hepatitis;Hepatitis C;Hepatitis C virus;HIV;Infection;innovation;invention;Lateral;lateral flow assay;Literature;low and middle-income countries;magnetic beads;Manuals;melting;Methodology;novel;Nucleic Acid Amplification Tests;Nucleic Acids;Outcome;Patients;Persons;point of care;point-of-care diagnostics;Populations at Risk;portability;Reagent;Research;sample collection;Sampling;Sensitivity and Specificity;Site;System;Technology;Temperature;Test Result;Testing;Tuberculosis;usability;Viral;Virion;Virus;Virus Diseases;virus testing;Visit;Whole Blood

PROJECT_TITLE: Point-of-care magnetofluidic HCV diagnostic using thermally responsive valves

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Neurosciences;Nutrition;Obesity;Sleep Research

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: Project Narrative Dysregulation of both sleep and metabolism presents an enormous health burden throughout the world. This proposal will investigate how genes and neurons modulate sleep in response to changes in metabolism. Functional investigation of the genes regulating sleep-metabolism interactions will provide the groundwork for understanding metabolic regulation of behavior and further our understanding of obesity, sleep disorders and diabetes.

PI_NAMEs: DUBNAU, JOSHUA T;KEENE, ALEX C (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Activity Cycles;Acute;Address;Adipose tissue;Adult;Animals;Behavior;Behavioral;Brain;Cell Physiology;cell type;Cells;Coculture Techniques;Communication;Cues;Cytosol;Desire for food;Diabetes Mellitus;differential expression;Disease;Drosophila genus;Epidemiology;experimental study;Fat Body;feeding;Female;fly;Food;Food deprivation (experimental);Gene Expression Profile;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic;Genetic Processes;Genetic Screening;Genetic Transcription;Health;Homeostasis;Hormones;Image;in vivo;in vivo imaging;Investigation;knock-down;Libraries;Link;Mammals;Measures;Metabolic;Metabolic syndrome;Metabolism;Modeling;Molecular;Molecular Profiling;mutant;neural;neural circuit;neuromechanism;Neurons;Neuropeptides;Neurophysiology - biologic function;neuroregulation;novel;Nutrient;Nutritional;Obesity;overexpression;patch sequencing;Peripheral;Physiological;Preparation;pressure;Prevalence;Protein Secretion;Regulation;response;Rest;RNA Interference;RNA interference screen;Satiation;sensor;Signal Transduction;single cell genomics;single-cell RNA sequencing;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep regulation;System;Tissues;tool;Transcript;ubiquitin ligase;Work

PROJECT_TITLE: Circuit level analysis of sleep-metabolism interactions

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition;Obesity;Physical Activity;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: JOSLIN DIABETES CENTER

PHR: PROJECT NARRATIVE Diabetes is a major public health problem and exercise has an essential role in the management and prevention of this disease. The goal of this research is to find out how exercise training causes fundamental changes to adipose tissue that signal the body to improve overall metabolism, including lowering blood sugar and lipid levels and enhancing function of other tissues such as liver, muscle and kidney. These studies will lead to a better fundamental understanding of the beneficial effects of exercise on health and may help to identify therapies for diabetes.

PI_NAMEs: GOODYEAR, LAURIE J (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: adipokines;adipose derived stem cell;Adipose tissue;Amphiregulin;Architecture;Area;Award;Biology;Blood Glucose;blood glucose regulation;blood lipid;Buttocks;Cardiometabolic Disease;Cardiovascular Diseases;Categories;Cells;Chromatin;Chronic Disease;Clinical;Collaborations;Complement;Complex;Computational Biology;Data;Dementia;Development;Diabetes Mellitus;diabetes mellitus therapy;diet-induced obesity;Disease;disorder prevention;Enzymes;Epidermal Growth Factor Receptor;Epigenetic Process;epigenome;Exercise;exercise training;Expression Profiling;Foundations;G-Protein-Coupled Receptors;Gene Expression;Gene Modified;Glycogen;glycogen metabolism;Goals;GTP-Binding Proteins;Health;High Fat Diet;Immune;Immunology;improved;in silico;In Vitro;in vivo Model;innovation;Kidney;Knockout Mice;lipidomics;Liver;Lymphoid Cell;Mediating;Mediator;Metabolic;Metabolic Diseases;Metabolism;Molecular;mouse model;multiple omics;Muscle;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity treatment;Organ;Phase;Phenotype;Physiological;Play;prevent;Prevention;problems and exercises;protein expression;Proteins;Proteomics;Public Health;Publishing;receptor;Regulation;Research;response;Risk;Role;Science;Signal Transduction;single cell analysis;skeletal muscle metabolism;Skin;stem cells;Stimulus;subcutaneous;System;therapy development;Thigh structure;Tissues;Training;transcriptome;transcriptome sequencing;transcriptomics;United States;Visceral

PROJECT_TITLE: Novel Mechanisms of Exercise Training Effects on Glucose Homeostasis

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Nutrition;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE It is projected that by 2030, one in every five Americans will be of retirement age, and this demographic shift is expected to result in more people suffering from dementia. A key feature of the brain is its need for a constant supply of glucose and oxygen to meet the high energy costs of mental activity. This program aims to develop clinically practical, noninvasive imaging methods based on combined positron emission tomography and mag- netic resonance imaging to assess brain energy in order to better understand how this critical component of brain health is impacted by aging.

PI_NAMEs: ST. LAWRENCE, KEITH ;WEHRLI, FELIX W (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Age;age related;Aging;Agreement;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;American;arterial spin labeling;Biological Markers;Blood flow;blood oxygen level dependent;Brain;brain health;brain magnetic resonance imaging;brain metabolism;burden of illness;Bypass;Calibration;Catheterization;Cell Respiration;cerebral blood volume;cerebral vein;Cerebrovascular Disorders;Cerebrum;Chronic;Clinical;Clinical Trials;Cognition;Cognitive;cognitive function;cognitive performance;Complex;Core-Binding Factor;cost;Crossover Design;Cyclotrons;Dementia;dietary supplements;Disease;Dropout;effective therapy;effectiveness evaluation;energy efficiency;Energy Metabolism;Ensure;enzyme activity;Etiology;Exhibits;Fatty Acids;fluorodeoxyglucose;Gases;Glucose;glucose metabolism;Glucose Transporter;Glycolysis;Goals;Half-Life;head-to-head comparison;Hybrids;Hypercapnia;Image;imaging approach;Imaging Device;imaging modality;improved;Individual;Inhalation;interest;Intervention;ketogentic;Ketones;Length;Link;Magnetic Resonance Imaging;Maps;Measurement;Measures;Metabolic dysfunction;metabolic imaging;metabolic rate;Metabolism;Methods;misfolded protein;Molecular;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimaging;Neurotransmitters;non-invasive imaging;novel;Nutrient;Older Population;Organ;Outcome;Oxidative Phosphorylation;Oxidative Stress;Oxygen;Oxygen saturation measurement;patient population;Patients;Pattern;Perfusion;Persons;Pharmaceutical Preparations;Physiological;Placebos;Population;Positron-Emission Tomography;prevent;Procedures;Production;programs;Psyche structure;quantitative imaging;Radiation Dose Unit;Research;response;Retirement;Risk;Sampling;Scanning;Senile Plaques;Signal Transduction;Site;Symptoms;System;tau Proteins;Testing;Therapeutic;Time;Tracer;United States;Validation;vascular risk factor;Venous

PROJECT_TITLE: Simultaneous PET/MR Imaging of Brain Glucose and Oxygen Metabolism to Assess Energy Deficits Related to Alzheimer's Disease and the Response to Intervention


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: Los Angeles

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative The proposed research is relevant to public health because it focuses on developing a new treatment strategy, an extracellular vesicle (exosome)-based novel intraocular drug delivery system providing active targeting of ocular neovascularization, capacity to deliver multiple drugs, and sustained efficacy to treat neovascular age- related macular degeneration (NVAMD), a leading cause of blindness in people older than 60 and a major increase in healthcare cost. Development of these strategies has great potential to upgrade the therapeutic efficacy, and to reduce the treatment burden by shifting the paradigm in ocular drug delivery from current passive targeting directed monotherapy to active targeting-directed multi-drug delivery with sustained efficacy for the treatment of NVAMD as well as other posterior eye diseases.

PI_NAMEs: LEE, SUN YOUNG  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Acceleration;Acids;antagonist;Binding;Blindness;Blood Vessels;Caveolins;Cell Communication;Cell Line;Cell secretion;cell type;Cells;Choroidal Neovascularization;Clathrin;Clinical;Combined Modality Therapy;Coupled;Development;Diabetic Retinopathy;Diffusion;Drug Delivery Systems;Economic Burden;Endocytosis;Endothelial Cells;Engineering;exosome;extracellular;extracellular vesicles;Exudative age-related macular degeneration;Eye diseases;Fibrosis;Formulation;Gliosis;Goals;Health Care Costs;Histologic;Human;Immune response;Immunologic Tests;In Vitro;Infection;Inflammation;Inflammatory Response;Injections;innovation;Integrins;intravitreal injection;Lasers;Lesion;Ligands;Lipids;Mediating;Membrane;MicroRNAs;Modeling;Modification;mouse model;Mus;nanosized;Natural regeneration;Nature;novel;novel strategies;novel therapeutic intervention;ocular neovascularization;Older Population;Pathologic;Pathway interactions;Patients;Penetration;Pharmaceutical Preparations;Physiological;Play;prevent;Process;Proteins;Public Health;receptor;receptor mediated endocytosis;Research;Retina;retinal angiogenesis;Retinal Degeneration;Retinal Vein Occlusion;RGD (sequence);Role;Site;socioeconomics;Standardization;Subgroup;System;targeted delivery;Testing;Therapeutic;Therapeutic Effect;Time;Toxic effect;translation to humans;Treatment Efficacy;Tube;uptake;Vascular Diseases;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Vision

PROJECT_TITLE: Extracellular vesicle-based intraocular therapy combined with active targeting of ocular neovascularization

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative Frailty is a common clinical condition in older adults that is characterized by increased vulnerability to disability and mortality, and is a major burden for the healthcare system in the United States. Aging is the main risk factor for frailty; however, families of centenarians delay aging and are protected from frailty. Identifying genes and biological markers that protect from the effects of aging is an important step in the development of effective therapies that protect from and delay frailty.

PI_NAMEs: MILMAN, SOFIYA  (contact);VERGHESE, JOE

PROGRAM_OFFICER_NAME: RAGHAVACHARI, NALINI

PROJECT_TERMS: Accounting;Age;age effect;age related;age related changes;Aging;Biological;Biological Markers;Biology;Biology of Aging;biomarker discovery;biomarker identification;Candidate Disease Gene;Centenarian;Clinical;Cognition;cohort;Collaborations;Complex;Dementia;Development;disability;disability risk;Disease;DNA Library;DNA Methylation;effective therapy;Effectiveness of Interventions;Epigenetic Process;epigenomics;Equation;Evaluation;exome sequencing;Failure;Family;follow-up;follower of religion Jewish;Founder Generation;frailty;Funding;gene discovery;Genes;Genetic;Genetic Markers;Genetic Risk;genetic variant;Genome;genome wide association study;genome-wide;Genomics;Goals;Grouping;Hand Strength;healthcare burden;Healthcare Systems;high risk;Homeostasis;Hormonal;Incidence;Individual;infection risk;Inflammatory;Inherited;insight;Intervention;Investigation;Longevity;Longitudinal cohort;Machine Learning;Measures;Metabolic;Methylation;Molecular;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;multiple omics;novel;offspring;older adult;Pathogenesis;Pathway interactions;Phenotype;Physical Function;physiologic stressor;Plasma;Plasma Proteins;polygenic risk score;Polygenic Traits;Population;Prevention;Proteins;Proteome;proteomic signature;Proteomics;Publications;rare variant;Recommendation;Reporting;Research;resilience;resilience biomarker;resilience in aging;Risk;Risk Factors;Sampling;sex;Site;SNP array;surgical risk;survival prediction;Syndrome;System;Techniques;Testing;Time;United States;Variant

PROJECT_TITLE: Multi-omics approach to frailty resilience

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Nutrition;Obesity;Pancreatic Cancer;Prevention;Rare Diseases

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative Obesity is a risk factor for pancreatic ductal adenocarcinoma (PDAC), a cancer that has a dismal 5-year survival rate largely related to limitations with prevention and treatment. Our project plans to elucidate mechanisms that contribute to the molecular changes that occur in the adipose tissue of obese individuals that can drive the development and progression of PDAC. Understanding how adipose-derived factors contribute to tumorigenesis will lead to novel targets to improve PDAC prevention and treatment and provide a model for future work in other obesity-associated cancers.

PI_NAMEs: CRUZ-MONSERRATE, ZOBEIDA  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Adipocytes;adipokines;Adipose tissue;Anabolism;Anti-Inflammatory Agents;Arachidonic Acids;Binding;Body Composition;Cardiolipins;Cell secretion;Cells;Chemoresistance;Clinical;Coculture Techniques;Complex;cyclooxygenase 2;cytokine;Data;Development;dietary;Early Diagnosis;Energy Metabolism;Enzymes;fatty acid metabolism;Fatty Acids;Future;Gelatinase B;Genetically Engineered Mouse;Goals;Growth;Health;Immune;immune cell infiltrate;improved;Inflammation;Inflammatory;insight;insulin sensitivity;Knowledge;LCN2 gene;Ligands;Linoleic Acids;Lipid Binding;lipidomics;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Metabolic dysfunction;Metabolic Pathway;Metabolism;Mitochondria;Modeling;Molecular;Monitor;Mus;novel;obese person;Obesity;Obesity associated cancer;obesity development;Obesity Epidemic;Organoids;pancreas development;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic stellate cell;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Plasma;prevent;Prevention;Prevention strategy;Process;Prostaglandins;protein complex;receptor;Risk Factors;Signal Transduction;Skeletal Muscle;Stromal Cells;Stromal Neoplasm;Supplementation;Survival Rate;systemic inflammatory response;Testing;Thinness;Tissues;treatment strategy;tumor;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Tissue;Tumor-Derived;tumorigenesis;Work

PROJECT_TITLE: Contributions of the Adipose Tissue to the Development of Pancreatic Cancer

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: Acute kidney injury is common, affecting 22% of Veterans admitted to VA intensive care units. As such, acute kidney injury is a major cause of morbidity and mortality in the Veteran population, and Veterans who survive are at risk of developing chronic kidney disease or end-stage renal disease. One in seven people in the United States has chronic kidney disease. Patients with end-stage renal disease require dialysis or kidney transplantation for survival. Kidney regeneration is poor following acute kidney injury and there are no treatments available at this time to directly encourage regeneration. New treatments that target regeneration of the kidney are needed. The human kidney is comprised of a limited set of nephrons that are present at birth. These nephrons are lost over time and can never be regained, so renal injuries can be lifelong. We seek to explore the use of reprogrammed progenitor cells and their extracellular vesicles for kidney regeneration.

PI_NAMEs: WOODARD, LAUREN ELIZABETH (contact)

PROJECT_TERMS: Acceleration;Acute Renal Failure with Renal Papillary Necrosis;Admission activity;Adult;Affect;animal imaging;Animal Model;Apoptosis;bench to bedside;Biological Markers;Birth;Bypass;cancer therapy;Cell Culture Techniques;Cell Death;Cell Differentiation process;cell immortalization;Cell Line;Cell Reprogramming;Cell Therapy;cell type;Cells;cellular engineering;Cessation of life;Chronic Kidney Failure;Cisplatin;Clinic;Complement;CRISPR/Cas technology;Cultured Cells;Data;Development;Diagnosis;Dialysis procedure;Distal;DNA cassette;Doxycycline;embryo cell;End stage renal failure;Endothelial Cells;engineered stem cells;Engineering;Epithelial Cells;Ethics;exhaust;exosome;extracellular vesicles;Fetal Development;Fetus;Fibrosis;Freeze Drying;gene therapy;Generations;Genes;Genetic Diseases;Genome engineering;histological studies;Histology;Homologous Transplantation;Human;human induced pluripotent stem cells;Image;Immune;Immune system;Immunocompromised Host;improved;induced pluripotent stem cell;Induction of Apoptosis;inhibitor;injured;Injury;injury and repair;Injury to Kidney;Intensive Care Units;Ischemia;Kidney;kidney cell;Kidney Diseases;Kidney Transplantation;LCN2 gene;Legal patent;Life;Luciferases;Mammals;Mass Spectrum Analysis;Measures;Mediating;mesenchymal stromal cell;Mesenchyme;military veteran;Modeling;Molecular;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;Natural regeneration;nephron progenitor;Nephrons;next generation;novel therapeutics;Organoids;Outcome;Pathway interactions;Patient Admission;Patients;Persons;Play;podocyte;Production;Proliferating;promoter;Property;Proteins;Proteome;Publishing;receptor;Recurrence;regenerative;regenerative treatment;Renal function;Reperfusion Injury;Reperfusion Therapy;Rhabdomyolysis;Risk;RNA;Role;single-cell RNA sequencing;Source;Specificity;Stains;stem cells;Stromal Cells;Surface;Techniques;Testing;Therapeutic;Therapeutic Effect;Time;tissue culture;Transcript;transcription factor;transcriptome;Transgenic Mice;Translations;Tubular formation;United States;urinary;Veterans

PROJECT_TITLE: Genome engineering of stem cells for kidney regeneration.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NEPH-N (01)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Lung;Lung Cancer;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: This ongoing project addresses a major challenge in medicinal chemistry, namely reducing the systemic toxicity of cancer chemotherapeutics. Building off success with platinum constructs, new texaphyrin conjugates with enhanced therapeutic and imaging functionality are proposed.

PI_NAMEs: MAIER, ESTHER Y.;QUE, EMILY L;SESSLER, JONATHAN L (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: A549;acute toxicity;Acute Toxicity Tests;Address;analog;Back;Biodistribution;Biological Assay;Blood;BRCA1 gene;BRCA1 Mutation;Breast Cancer Cell;Breast Cancer cell line;Cancer cell line;Cancer Patient;Cell Death;cell killing;Cell Line;Cells;Characteristics;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;Collaborations;Complex;cost;CT26;Development;Diagnostic;Dose Limiting;experience;Funding;Gadolinium;Gold;Growth;Heart;Heating;Image;Immune response;Immunologic Stimulation;improved;In Vitro;in vivo;Inductively Coupled Plasma Mass Spectrometry;inhibitor;Injections;interest;Kidney;Kyocristine;Lanthanoid Series Elements;Lead;Light;Liver;lung cancer cell;Magnetic Resonance Imaging;Malignant neoplasm of ovary;Malignant Neoplasms;Manganese;MDA MB 231;Medical;Metals;Molecular;mouse model;Mus;Mutate;Nausea and Vomiting;Nuclear Magnetic Resonance;Oncology;Organ Harvestings;Ovarian;oxaliplatin;patient derived xenograft model;Pattern;Pharmaceutical Chemistry;Pharmaceutical Preparations;photoactivation;photothermal therapy;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Porphyrins;preclinical development;Prednisone;Preparation;Property;Protons;Pyrroles;quantum;Reactive Oxygen Species;Regimen;Research Personnel;Resistance;side effect;Signal Transduction;Site;small molecule;Spleen;success;synergism;System;systemic toxicity;Temperature;Testing;Texaphyrin;Therapeutic;triple-negative invasive breast carcinoma;tumor;tumor growth;Visualization;Water;Work

PROJECT_TITLE: Biomedical Applications of Expanded Porphyrins

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Microbiome;Neurodegenerative;Neurosciences;Nutrition;Peripheral Neuropathy

ORG_CITY: EAST LANSING

ORG_DEPT: PHYSIOLOGY

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: Project Narrative  PUBLIC HEALTH RELEVANCE: Gut microbiota play a vital role in metabolism, endocrine, and immune system. Extracellular vesicles (EVs), small bilipid layer containers, mediate intercellular communication and hold great potential in drug delivery and therapy. We will investigate the novel role of gut microbiota-derived EVs in the progression of diabetic peripheral neuropathy (DPN), the most prevalent chronic complications of diabetes patients, and examine whether commensal beneficial microbiota-derived EVs can be employed as a potential therapeutic target against DPN and the underlying molecular mechanisms. Our work will provide new insights into the pathogenesis of DPN and may lead to the development of novel therapeutic agents for patients with DPN.

PI_NAMEs: LIU, XIANSHUANG  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: 16S ribosomal RNA sequencing;Abbreviations;Ablation;Affect;Afferent Neurons;Antibiotics;Attenuated;bacterial genetics;Biocompatible Materials;Cardiovascular system;Cells;Chronic;clinically relevant;Communication;Complications of Diabetes Mellitus;Data;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Disease;Drug Delivery Systems;effective therapy;Endocrine system;Engineering;extracellular vesicles;feeding;Gnotobiotic;gut bacteria;gut dysbiosis;gut microbiota;High Fat Diet;Homeostasis;Human;Hyperglycemia;Immune response;Immune signaling;Immune system;immunoreaction;improved;In Vitro;Inflammatory;insight;intercellular communication;Intestines;JAK2 gene;Janus kinase;knock-down;Lactobacillus;Macrophage;Mediating;Metabolic;Metabolic syndrome;Metabolism;microbial composition;microbiota;microbiota composition;Molecular;monocyte;Morbidity - disease rate;mortality;Mus;Nerve Tissue;Neurites;neuroinflammation;Neurons;Neuropathy;new therapeutic target;non-diabetic;novel;novel therapeutics;nutrition;old mice;overexpression;Pathogenesis;Pathway interactions;Patient Agents;Patients;peripheral nerve damage;Peripheral Nerves;Peripheral Nervous System Diseases;Pharmacotherapy;Pilot Projects;Play;Production;public health relevance;RNA;Role;sciatic nerve;Signal Pathway;Signal Transduction;Spinal Ganglia;STAT protein;STAT3 gene;Stat3 Signaling Pathway;Streptozocin;systemic inflammatory response;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Transfer RNA;Transgenic Mice;treatment strategy;Work

PROJECT_TITLE: Investigating the role of gut extracellular vesicles in diabetic peripheral neuropathy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


FUNDING_MECHANISM: OTHERS

PHR: Frailty, a multi-component phenotype of having a decreased capacity to recover from a health-related stressor, impacts three out of ten Veterans over 65 and independently associates with increased mortality risk. Chronic kidney disease (CKD) confers a nearly 80% higher odds of frailty. No interventions improve frailty or frailty risk in CKD, and no interventions are currently able to be targeted to those who would most benefit. Physical activity is the component of the frailty phenotype that predicts mortality and dialysis initiation in CKD, and recent evidence suggests that biomarkers of senescence are reduced after exercise. This proposal will 1) identify novel psychosocial factors associated with physical activity frequency among older Veterans with CKD; 2) develop and pilot test an intervention targeted to these mechanisms to increase physical activity; and 3) explore whether biomarkers of senescence can predict intervention treatment response.

PI_NAMEs: NAIR, DEVIKA  (contact)

PROJECT_TERMS: Address;Adult;Behavior;behavior change;Behavior Therapy;Biological Markers;biomarker identification;Body Weight decreased;career;Cell Cycle Arrest;Cessation of life;Chronic Kidney Failure;Classification;Clinical;Clinical Practice Guideline;Cognition;Confidence Intervals;Creatinine;Data;Dedications;Diagnosis;Dialysis procedure;Dose;effective intervention;Environment;Evidence based program;Exercise;exercise capacity;exercise intervention;Exhibits;experience;Fatigue;feasibility testing;Foundations;frailty;Frequencies;Future;Gait speed;Guidelines;Hand Strength;hazard;Health;Health behavior;high risk;improved;Individual;innovation;Intervention;Interview;Literature;Lower Extremity;Measures;mortality;mortality risk;Motivation;multiple chronic conditions;Muscle;muscle form;muscle strength;Muscle Weakness;Muscular Atrophy;National Institute on Aging;novel;older adult;Outcome;Pain;Pain intensity;Pathogenesis;Patient Self-Report;Patients;Phenotype;Physical activity;Physiological;pilot test;Population;post intervention;Prediction of Response to Therapy;predictive marker;Preparation;pressure;Prevalence;psychologic;psychosocial;Psychosocial Factor;Randomized;Reporting;resistance exercise;response;Risk;Sampling;sedentary;Self Care;Self Efficacy;senescence;Serum;skills;Social support;stressor;Testing;theories;Theory of Change;Time;Treatment Efficacy;treatment response;Veterans;Walking

PROJECT_TITLE: Activation for Self-Care Needs in Older Adults with Chronic Kidney Disease: ACTIVE SENIORS with CKD.


ORG_CITY: NEW YORK

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: NARRATIVE This project aims to illuminate the molecular mechanism of the human sodium-dicarboxylate transporter NaDC3 by structurally characterizing its complete reaction cycle. Structures of the protein with substrates and inhibitors bound will establish the structural basis of the transporter’s substrate specificity and the mechanisms of inhibition. Such knowledge will in turn help us to understand the signaling pathways that control cell fate and aid us in the design of therapeutics in treating Canavan disease and other disorders.

PI_NAMEs: WANG, DANENG  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Address;Affect;Affinity;alpha ketoglutarate;Binding;Binding Sites;Biochemical;Biological Assay;Brain;brain cell;Canavan Disease;Cell Fate Control;Cell membrane;Cell Volumes;Cells;Central Nervous System Diseases;citrate carrier;Citric Acid Cycle;conformational conversion;Coupled;Coupling;Cryoelectron Microscopy;Data;design;dicarboxylate;dicarboxylate-binding protein;dimer;Disease;disease-causing mutation;early onset;Elevator;Epilepsy;Eukaryota;Family;Funding;Genes;Homologous Gene;Homologous Protein;Human;Individual;inhibitor;Knowledge;Lipids;Mediating;Molecular;Molecular Conformation;Movement;Mutation;Myelin;N-acetylaspartate;Neuroglia;Neurohormones;Neurons;Neuropeptides;neurotoxicity;neurotransmission;Neurotransmitters;Oligodendroglia;Osmosis;Pathway interactions;Patients;Physiology;Play;protein structure;Proteins;Reaction;Regulation;Role;Signal Pathway;Signaling Molecule;small molecule inhibitor;Sodium;stem cell differentiation;stem cell proliferation;Stress;Structure;Substrate Specificity;Succinates;symporter;Testing;Therapeutic;Tissues;uptake;white matter;Work

PROJECT_TITLE: Transport Cycle and Inhibition of Human Na+-dicarboxylate Cotransporter NaDC3

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Genetics;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE Type 1 diabetes (T1D) is a disease characterized by T cell mediated beta cell destruction. The mechanisms behind long-term functional persistence of autoimmune T cells under conditions of chronic inflammation and continuous immune activation, which should curtail immune responses, are not well understood. We will determine the role of resident and recruited CD4 T cells in maintaining tissue autoimmunity, and mechanisms behind the persistence of high and low affinity autoimmune T cells.

PI_NAMEs: BETTINI, MARIA  (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Address;Affinity;Antigens;Autoantigens;Autoimmune;Autoimmune Diabetes;Autoimmunity;autoreactive T cell;autoreactivity;Beta Cell;Biological Markers;CD3 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Count;Cells;Chromatin;Chronic;Chronic Disease;Data;Development;Diabetes Mellitus;Disease;Disease remission;Epigenetic Process;epigenetic regulation;Epitopes;Etiology;exhaustion;Exhibits;experience;Gene Expression Profile;Genetic Transcription;Heterogeneity;immune activation;Immune response;Immunotherapeutic agent;improved;Inbred NOD Mice;Infiltration;Inflammation;Insulin;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans;Knowledge;loss of function;Maintenance;Measurement;Mediating;Memory;Methylation;Molds;Mus;Mutant Strains Mice;Pancreas;pathogen;Pathogenicity;Peripheral;Phenotype;Population;Predisposition;recruit;Regulation;Resistance;response;restraint;Role;self-renewal;SELL gene;Signal Transduction;Site;Source;stem;stem cells;stemness;T cell infiltration;T cell response;T memory cell;T-Cell Receptor;T-Lymphocyte;Testing;Tissues;tool;trafficking;transcription factor;Transcriptional Regulation;whole genome;Work

PROJECT_TITLE: Mechanisms of T cell persistence during chronic autoimmunity

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CHICAGO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Genetic studies of immune-related disorders have discovered a number of genetic variants associated with the risk of these diseases, yet, to translate these data into knowledge of the underlying genes and identify potential therapeutic targets is challenging. To fill this gap, we propose to study the effects of genetic variants, in human immune cells, on RNA modification, an important mechanism that controls RNAs and may affect the risk of diseases. We expect our study to uncover variants and genes that play important roles in immune disorders.

PI_NAMEs: BARREIRO, LUIS BRUNO;HE, XIN  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Asthma;B-Lymphocytes;Binding;Biological Process;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Line;cell type;Cells;Chromatin;Communities;Complex;Computational Technique;Data;Data Set;data to knowledge;Disease;disorder risk;empowerment;Enhancers;Epigenetic Process;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;genome wide association study;Goals;Heritability;Human;human disease;Human Genetics;Immune;Immune system;Immune System Diseases;Immunologic Stimulation;improved;insight;Intracellular Transport;Lead;lymphoblastoid cell line;Maps;Medical;Messenger RNA;Methods;Modification;Molecular;monocyte;neurodevelopment;novel;Nuclear Export;Organism;Phenotype;Play;Predisposition;Process;Quantitative Trait Loci;recruit;Regulation;Resources;response;Rest;Risk;risk variant;RNA;RNA Degradation;RNA Processing;RNA Splicing;Role;Sample Size;Signal Transduction;Site;Spliced Genes;Statistical Methods;T-Lymphocyte;Testing;therapeutic target;tool;trait;transcription factor;Transcriptional Regulation;transcriptome;Translating;Translations;tumorigenesis;Untranslated RNA;Variant;variant detection;Work

PROJECT_TITLE: Genetic variation of N6-methyladenosine (m6A) RNA modification in immune cells and its contribution to human diseases

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: Project Narrative The proposed research is relevant to public health because the efficacious treatment of children with speech sound disorders is paramount to their academic and social success. School-based speech-language pathologists are well-poised to adapt clinical decisions related to the speech sound therapy environment to ensure positive therapy outcomes. Thus, this exploratory pre-implementation research aligns with NIDCD’s goal to advance the science of communication to improve lives by determining what works for whom to optimize school-based therapy outcomes, related to phonological knowledge, for elementary-aged children with speech sound disorders.

PI_NAMEs: CABBAGE, KATHRYN ;FARQUHARSON, KELLY  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Age;aged;Characteristics;Child;Clinical;clinical decision-making;Clinical Research;cohort;Communication;Complex;Decision Making;Development;Disease;Distal;dosage;efficacious treatment;efficacy evaluation;elementary school;empowerment;Ensure;Environment;Equilibrium;evidence base;first grade;Frequencies;Goals;Group Therapy;Impairment;implementation research;improved;Individual;Individual Differences;innovation;Intervention;Investigation;kindergarten;Knowledge;Language;Learning;Learning Disabilities;Length;Measurable;Measures;National Institute on Deafness and Other Communication Disorders;Nature;neglect;Outcome;Pathologist;Pathway interactions;Performance;phonological awareness;phonology;Population;Prediction of Response to Therapy;Production;Public Health;Reading;Research;Resources;Sampling;School Health Services;Schools;Science;second grade;Services;Short-Term Memory;skills;social;sound;Speech;Speech Perception;Speech Sound;Speech Therapy;spelling;success;therapy outcome;Time;Treatment Efficacy;United States;Variant;Work;Workload

PROJECT_TITLE: Academic Progress in Phonological Learning for Elementary School children with speech sound disorders (APPLES)

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Our research indicates that dystrophic neurites that surround amyloid plaques in Alzheimer's disease (AD) are caused by Aβ-induced membrane damage leading to calcium leakage, kinase activation, and tau hyperphosphorylation, suggesting a mechanism that links Aβ and tau pathologies. Moreover, dystrophic neurites may be crucibles of AD tau seeding and spreading that ultimately results in synaptic loss, neuron death, and cognitive impairment in AD. We discovered that the membrane repair protein annexin A6 reduces dystrophic neurite formation and pathologic tau phosphorylation, so in this R01 we will explore whether annexin A6 can ameliorate dystrophic neurites, tau hyperphosphorylation, and the seeding and spreading of AD tau in mouse models of amyloid pathology, which could provide therapeutic proof-of-concept supporting annexin A6 for the prevention or treatment of AD.

PI_NAMEs: SADLEIR, KATHERINE R.;VASSAR, ROBERT J (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Aducanumab;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease therapeutic;Amyloid;Amyloid beta-42;Amyloid beta-Protein;amyloid pathology;Annexin A6;Astrocytes;Axon;Axonal Transport;Behavioral;beta amyloid pathology;Biochemical;Biological Assay;Brain;Brain Edema;Brain hemorrhage;Calcium;Cell membrane;Clinical;Cognitive;Combined Modality Therapy;conditioned fear;Dementia;density;Disease;Disease Progression;Dominant-Negative Mutation;Drug Targeting;Dyes;early detection biomarkers;Electrophysiology (science);experimental study;Extravasation;FDA approved;Goals;Growth;Homeostasis;Human;hyperphosphorylated tau;Image;Immunoblot Analysis;Immunohistochemistry;Impaired cognition;Impairment;improved;In Vitro;in vivo;individual patient;knock-down;Knock-in Mouse;Laser injury;Link;Mediating;Membrane;Memory impairment;Microglia;Microtubules;Molecular;Morphology;mouse model;Mus;Neurites;Neurofibrillary Tangles;neuron loss;Neurons;new therapeutic target;novel;object recognition;overexpression;Pathologic;Pathology;Penetration;Pharmaceutical Preparations;Phosphotransferases;precision medicine;Prevention;Proteins;Recombinants;repaired;Research;Role;Senile Plaques;side effect;Synapses;tau aggregation;tau Proteins;tau-1;tau-protein kinase;Testing;Therapeutic;Threonine;water maze;Work

PROJECT_TITLE: Exploring annexin A6 for the prevention of dystrophic neurites and tau seeding and spreading in Alzheimer's disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention

ORG_CITY: KINGSTON

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: Project Narrative Although empirical evidence supports a strong relationship between human eating behaviors, food intake, and obesity, research outside the lab and development of interventions to improve eating behaviors have been hindered by lack of accurate automated technology to track free-living eating behaviors. This project will develop and test a discreet wearable device assembly to track a key combination of eating behaviors, starting with laboratory validations and progressing to free-living situations with a variety of foods and beverages in adults across a broad range of BMI, age, genders, and race/ethnicity, with oversampling from LatinX communities, who experience higher prevalence of obesity and associated co-morbidities. The long term goal is to enable researchers to better understand how real-world eating behaviors influence body weight regulation and health, how eating behaviors can effectively be modified, and how people can be provided with tools to improve their everyday eating behaviors.

PI_NAMEs: MELANSON, KATHLEEN J (contact);WALLS, THEODORE ADRIEN

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Adult;Age;Algorithms;Anterior;Awareness;Basic Science;Behavior;behavior influence;Behavior monitoring;Beverages;biobehavior;Bite;Body mass index;Body Weight;bone;Clinical Trials;Communities;comorbidity;Computers;Consumption;COVID-19 pandemic;Data;Data Collection;Deglutition;design;Detection;detection platform;detection test;Devices;Diet;digital;disorder risk;Disparity population;Ear lobe;Eating;Eating Behavior;Ecological momentary assessment;Energy Intake;Engineering;Environment;Ethnic Origin;evidence base;experience;feature detection;Feedback;Feeding behaviors;Food;Frequencies;Future;Gender;Gestures;Goals;Health;Healthy Eating;healthy weight;hedonic;High Prevalence;Home;Human;Hunger;Hyperphagia;improved;In Situ;Incidence;Individual;innovative technologies;instrument;interest;Intervention;Laboratories;Laboratory Finding;Latinx;Latinx population;Life;Link;longitudinal analysis;loss of control over eating;Mastication;Measurement;Measures;Methodology;Modification;Monitor;mortality;Motion;Movement;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nutritionist;Obesity;Obesity Epidemic;obesity risk;Oral;Oral cavity;Participant;Patient Self-Report;Performance;Persons;Population;population based;Population Heterogeneity;Populations at Risk;Prevalence;programs;Protocols documentation;Psychologist;Race;Regulation;Research;Research Personnel;Research Project Grants;Restaurants;Risk;Sampling;Satiation;Schools;sensor;Signal Transduction;Skin;Standardization;Strategic Planning;Stress;System;Systems Development;Technology;Testing;therapy development;Time;tool;user-friendly;Validation;validation studies;Video Recording;Viscosity;wearable device;Weight;Weight Gain;Weight maintenance regimen;Work;Wrist

PROJECT_TITLE: Lab and real-world validation of a system for monitoring ingestive behavior

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE The notochord is the main embryonic axial structure necessary for development and patterning of the body plan, and in humans impaired notochord formation can result in birth defects, vertebral malformations and bone- derived malignant tumors called chordomas. The transcription factor Brachyury is known to be indispensable for notochord development and to be an etiological agent of chordoma; however, it is still unclear how this transcription factor coordinates the temporal expression of all its numerous target genes, which in turn control different stages of notochord formation, and how Brachyury-downstream transcription factors allow Brachyury to control late-onset genes required for morphogenesis and differentiation of the notochord. The research proposed here will fill these gaps in knowledge by studying how temporal information is encoded in notochord cis-regulatory regions directly controlled by Brachyury, by reconstructing the gene batteries that are regulated by Brachyury-downstream transcription factors, and by elucidating how transcriptional repressors refine notochord gene expression.

PI_NAMEs: DI GREGORIO, ANNA  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Binding Sites;Body Patterning;bone;Brachyury protein;Cell Nucleus;Cell Shape;Cells;Central Nervous System;Chordata;Chordoma;cohort;Congenital Abnormality;convergent extension;Defect;Development;Developmental Process;Diagnosis;Disabling;early onset;Embryo;Embryonic Development;Endoderm;Enhancers;Ensure;Etiology;Event;Exhibits;Extracellular Matrix;field study;Gene Activation;Gene Expression;gene regulatory network;gene repression;Gene Transfer Techniques;Generations;Genes;Genetic Transcription;Genome;Goals;Heart;Heart Abnormalities;Human;Impairment;Individual;insight;Intervertebral disc structure;Invertebrates;Knowledge;Liver;malformation;Malignant Neoplasms;marine;Modality;Molecular;Morphogenesis;Mutation;Nature;neural patterning;Neural tube;notochord;notochord development;Nucleic Acid Regulatory Sequences;Organ;Organism;Pancreas;Paraxial Mesoderm;Pathology;Pattern;Pregnancy;prevent;Primitive foregut structure;Process;programs;Regulation;Research;Role;Signal Transduction;Spinal Dysraphism;spine bone structure;Structure;Testing;Tissue Differentiation;transcription factor;Transcription Repressor;Transgenic Organisms;tumorigenesis;Urochordata;Vertebral column;Vertebrates

PROJECT_TITLE: Control of precisely timed gene expression during notochord development by Brachyury

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Nutrition;Obesity

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative: Non-alcoholic fatty liver diseases (NAFLD), which affect more than 10-40% of adults worldwide with 60% in diabetic patients and 90% in obese people, can progress to liver fibrosis and further advance to cirrhosis and hepatocellular carcinoma. DNA methylation/demethylation, likely regulated by the TET1 enzyme, is highly associated with NAFLD development and progression. Determining the role of TET1 in preclinical NAFLD models will yield results toward establishing TET1 as a potential target for treating NAFLD patients.

PI_NAMEs: HUANG, CHIUNG-KUEI  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Adipocytes;Adult;Affect;Alcohols;Biochemical Reaction;Bioinformatics;Cause of Death;CD36 gene;Cells;Cirrhosis;Clinical;CRISPR/Cas technology;Cytosine;Data;demethylation;Development;diabetic patient;diet-induced obesity;Dioxygenases;disease model;Disease Progression;DNA;DNA Methylation;DNA Modification Methylases;DNMT3a;DNMT3B gene;Enzymes;Epigenetic Process;experimental study;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;feeding;Fibrosis;Gene Expression Regulation;Genes;Goals;Hepatic;Hepatocyte;High Fat Diet;Human;Hypermethylation;Immune;improved;In Vitro;in vivo;Inflammation;Inflammatory Response;Knock-out;Knockout Mice;Lead;Link;lipid metabolism;Lipids;Liver;liver development;Liver Fibrosis;liver function;liver inflammation;Macrophage;Mediating;Metabolic;methyl group;Modeling;mouse model;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;obese person;Obesity;Pathogenesis;Patients;Play;Population;Positioning Attribute;pre-clinical;Primary carcinoma of the liver cells;Process;Protein Family;Proteins;Reporting;Resistance;Role;Sampling;Series;Severity of illness;Signal Transduction;Somatomedins;System;Therapeutic;Tissues;transcriptome sequencing;Translating;Viral;Weight Gain

PROJECT_TITLE: TET1 in non-alcoholic fatty liver disease development

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE When vision loss becomes irreversible, some solutions seek to assist patients to substitute vision with their remaining sensory modalities by converting live visual information into patterns of sound or touch. In this project, we aim to further develop such technologies and identify the neurobehavioral effects of sensory substitution training in brains deprived of visual input via advanced neuroimaging and performance assessments. Results of this study can help determine how to leverage these new patterns of alternative senses via the plastic brains in the blind to improve their independence of living and to facilitate connections with others for better health outcomes.

PI_NAMEs: CHAN, KEVIN C (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Adoption;Age;Age of Onset;Artificial Intelligence;Auditory;basal forebrain;Behavior assessment;Behavioral;blind;Blindness;Brain;Chemicals;Choline;clinical training;Code;Color;Complex;cost;Cues;Development;Devices;Environment;Equilibrium;Esthetics;Eye;Feedback;Functional disorder;functional improvement;gamma-Aminobutyric Acid;Glutamates;Goals;Health;Human;Image;Implant;improved;Individual;interest;Knowledge;Learning;Link;Magnetic Resonance Imaging;Metabolic;Methods;Modality;neural;neurobehavioral;Neurobiology;neurochemistry;neuroimaging;Neuronal Plasticity;neurophysiology;Neurotransmitters;novel;Ocular Prosthesis;Operative Surgical Procedures;Outcome;Participant;Pathway interactions;Patients;Pattern;Perception;Perceptual learning;Performance;Positioning Attribute;preservation;Process;Property;Rehabilitation therapy;Research;Resolution;Retina;Semantics;sensor;Sensory;sensory substitution;Shapes;Signal Transduction;sound;Spectrum Analysis;Stimulus;Tactile;tactile stimulation;Task Performances;Technology;Testing;Time;Touch sensation;Training;Training Programs;Translating;Vision;vision rehabilitation;Visual;Visual Acuity;Visual Cortex;visual information;Visual Pathways;visual processing;Visual System;Visually Impaired Persons

PROJECT_TITLE: Sensory Substitution and Brain Plasticity Following Vision Loss

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


PHR: Narrative Dysfunctional repair of the alveolar epithelium following recurrent/chronic injury has been hypothesized as central to the pathogenesis of pulmonary fibrosis, but mechanisms driving dysfunctional repair are not well understood. Our preliminary data indicate that repeated injury to a regenerating alveolar epithelium is associated with persistent activation of hypoxia-inducible factor (Hif) signaling and suggest persistent Hif activation in regenerating alveolar epithelial cells (AECs) prevents their terminal differentiation and restoration of normal function. In these studies, we will utilize transgenic mouse models, state-of-the art single-cell genomics, and ex-vivo organoid models to investigate the mechanisms through which Hif- signaling regulates AEC regeneration and examine whether inhibiting Hif activation can prevent or reverse experimental lung fibrosis.

PI_NAMEs: KROPSKI, JONATHAN ANDREW (contact)

PROJECT_TERMS: Acute;airway regeneration;Alveolar;alveolar epithelium;alveolar homeostasis;ATAC-seq;Automobile Driving;bHLH-PAS factor HLF;Binding;Bleomycin;Cell Maturation;cell regeneration;Cells;ChIP-seq;Chronic;chronic respiratory disease;Co-Immunoprecipitations;Coculture Techniques;Complex;Data;Diagnosis;differential expression;Disease;Disease Progression;Distal;effective therapy;ELK1 gene;Epithelial Cells;epithelial repair;Epithelium;epithelium regeneration;ETS1 gene;ETS2 gene;Exhibits;experimental study;Failure;Family;Family member;Fibroblasts;Gases;Gene Expression;Genes;Genetic;Genetic Transcription;Genomics;HIF1A gene;Human;Hyperplasia;Hypoxia;Hypoxia Inducible Factor;In Vitro;in vivo;Injury;insight;Interruption;Investigation;knock-down;Link;Lung;lung regeneration;Lung Transplantation;Mediating;Mediator;Metaplasia;military veteran;Modeling;Morbidity - disease rate;mortality;mouse model;multiple omics;Mus;Natural regeneration;new therapeutic target;Nuclear;Organoids;Pathogenesis;Patients;prevent;Profibrotic signal;progenitor;programs;Proliferating;Pulmonary Fibrosis;Recurrence;regeneration function;Regulation;repaired;Reporter;Resolution;respiratory;Respiratory Failure;Response Elements;restoration;Role;Secretory Cell;Signal Transduction;single cell genomics;single-cell RNA sequencing;Sorting;stem cells;Testing;transcription factor;transcriptomics;Transgenic Mice;Transitional Cell;Work

PROJECT_TITLE: Mechanisms of alveolar homeostasis and repair.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 PULM-T (01)]