NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Genetic Testing;Genetics;Health Services;Human Genome;Primary Health Care

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Psychosocial assessment is a core component of genetic counseling practice but has not been systematically studied. The proposed research will be the first to characterize current psychosocial assessment practices in genetic counseling and pilot a standardized psychosocial assessment tool, the BATHE method, which has been found to be useful and effective in other healthcare fields. The ultimate goal of this foundational study is to provide a basis for further evaluation and implementation of effective and consistent psychosocial assessment practices to benefit all genetic counseling patients.

PI_NAMEs: CAMPION, MARYANN W (contact)

PROGRAM_OFFICER_NAME: LOCKHART, NICOLE C

PROJECT_TERMS: acceptability and feasibility;Accreditation;Address;Adoption;Adult;Affect;Anxiety;anxiety reduction;Appointment;Area;Assessment tool;Attention;California;Cardiology;Caring;Certification;Characteristics;Client satisfaction;Clinical;clinical care;clinical practice;Competence;Consultations;Consumption;coping;Counseling;Data;Development;Educational workshop;Emotional;Emotions;empowerment;Ensure;Evaluation;experience;Exploratory/Developmental Grant;Feedback;Foundations;Funding;Genetic Counseling;genetic counselor;genetic testing;Genomics;Goals;Health;health care settings;Healthcare;Hearing;Hereditary Malignant Neoplasm;impression;improved;innovation;Institution;instrument;Interview;Investigation;Learning;Literature;Malignant Neoplasms;Medical Genetics;medical specialties;Medicine;Methods;Modeling;Modification;National Human Genome Research Institute;Neurology;Outcome;Participant;Patient-Centered Care;Patient-Focused Outcomes;Patients;person centered;Practice Guidelines;prenatal;Primary Care;primary care setting;Process;Provider;psychologic;psychological distress;Psychological Impact;psychosocial;Psychosocial Assessment and Care;Questionnaires;randomized trial;Research;response;Sampling;satisfaction;skills;social;Social Work;Standardization;Strategic vision;Structure;Surveys;Techniques;Time;tool;Training;Transcript

PROJECT_TITLE: Piloting a standardized psychosocial assessment tool (BATHE) in genetic counseling


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: MADISON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Digital technology, including recorded speech, has the capability of providing a wealth of information about early changes to cognition and communication associated with developing Alzheimer’s disease pathology, with the potential for highly accessible, yet low-burden measurement. In this innovative proposal, we leverage existing and prospectively collected speech data from two longitudinal cohort studies to examine novel acoustic and linguistic measures and their associations with amyloid, tau, neurodegeneration, and progression to clinical impairment, using signal processing, machine learning, and theory-driven methods. By recruiting a subset of these participants to record their speech at home with a mobile device, our interdisciplinary team can validate digital markers across all stages of ADRD, including the prodromal phase, and can enhance sensitivity and specificity of speech metrics while contributing valuable information about remote, noninvasive, and accessible assessment and disease monitoring.

PI_NAMEs: MUELLER, KIMBERLY D (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Acoustics;Adult;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Anterior;Area;automated assessment;Biological Markers;Cerebrospinal Fluid;Clinical;clinical diagnosis;clinical trial recruitment;Cognition;Cognitive;cognitive change;cognitive function;cohort;Collection;Communication;Consumption;cost;Cultural Sensitivity;Data;Dementia;digital;digital assessment;Digital biomarker;digital monitoring;digital technology;Disease;Early Diagnosis;Early Intervention;Exhibits;frontal lobe;Goals;handheld mobile device;Home;Image;Impaired cognition;Impairment;Improve Access;improved;Individual;Inferior;innovation;Intervention;Language;language outcome;large scale data;Lead;Linguistics;Liquid substance;Longitudinal cohort study;longitudinal, prospective study;Machine Learning;Magnetic Resonance Imaging;Measurement;Measures;Memory Loss;Methods;mild cognitive impairment;mobile application;Modeling;Monitor;Natural Language Processing;Nerve Degeneration;Neurons;neuropathology;Neuropsychological Tests;novel;older adult;Outcome;Parietal Lobe;Participant;participant enrollment;Pathology;Pattern;performance based measurement;Persons;Phase;Plasma;Populations at Risk;Positron-Emission Tomography;pre-clinical;Procedures;prodromal Alzheimer's disease;prospective;Quality of life;recruit;Registries;Research;Risk;Sampling;Self Administration;Semantic memory;Sensitivity and Specificity;signal processing;Speech;stability testing;Standardization;supervised learning;System;tau Proteins;Temporal Lobe;Testing;theories;Time;tool;underserved community;Underserved Population;usability;Validation;Wisconsin;Work

PROJECT_TITLE: Connected Language and Speech Along the Spectrum of Alzheimer’s Disease and Related Dementias: Digital Assessment and Monitoring.

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BOSTON

ORG_NAME: JOSLIN DIABETES CENTER

ORG_STATE: MA

PHR: Project Narrative Obesity is epidemic throughout the population and is a major driving force in the epidemic of type 2 diabetes, metabolic syndrome and many other disorders. This grant focuses on defining the interactions between adipocyte heterogeneity, insulin signaling and exosomal miRNA mediated cellular communication in the pathogenesis of these disorders. It also explores new techniques to directly track adipose-derived exosomes and their miRNAs, as well as their potential role as novel therapeutics.

PI_NAMEs: KAHN, C RONALD (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Adipocytes;Adipose tissue;Adrenergic Agents;Affect;Aging;Area;Body Weight decreased;Brown Fat;Cells;Cholesterol;Communication;COVID-19;Data;Dependence;Development;Developmental Gene;Diabetes Mellitus;Dicer Enzyme;Disease;Distant;driving force;Endocrine system;Energy Intake;Energy Metabolism;Epidemic;Equilibrium;exosome;Fasting;Fatty acid glycerol esters;feeding;Gene Expression;Glucose Clamp;glucose metabolism;Grant;Health;Heterogeneity;Human;IGF1 gene;improved;in vivo;Insulin;Insulin Receptor;insulin signaling;Investigation;Knock-out;Knockout Mice;Label;lipid metabolism;Lipodystrophy;Lipoproteins;Mediating;Metabolic;Metabolic syndrome;Metabolism;MicroRNAs;Modeling;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;obesity development;Pathogenesis;Population;Process;protein biomarkers;Protein Sortings;Proteins;Publications;Publishing;Regulation;response;RNA-Binding Proteins;Role;Signal Transduction;single cell analysis;Small RNA;Sorting;Source;Stress;System;Techniques;Therapeutic;therapeutic miRNA;therapeutic protein;Tissues;transcription factor;Transfer RNA;transgene expression;Transgenic Mice;United States National Institutes of Health;unpublished works;Work

PROJECT_TITLE: Developmental genes, miRNAs and adipose tissue

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ORG_CITY: PHOENIX

ORG_NAME: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER

ORG_STATE: AZ

PHR: Project Narrative Clinical studies have consistently shown a strong association between aging and increased risk for intracranial aneurysmal rupture (i.e., aneurysmal subarachnoid hemorrhage). One of the hallmarks of aging is cellular senescence, a state of permanent proliferative arrest. We will study the mechanisms by which aging and cellular senescence promote aneurysm rupture to develop new therapies that target aging-related biological processes or senescence to prevent aneurysm rupture.

PI_NAMEs: EGUCHI, SATORU ;HASHIMOTO, TOMOKI  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: adverse outcome;Affect;age effect;age related;Aging;aging population;aging related;Aneurysm;Aneurysmal Subarachnoid Hemorrhages;Biological;Biological Process;Cardiovascular Diseases;Cell Aging;Cell secretion;Cell Survival;cell type;Cells;Cellular Stress;cerebral artery;Chronology;Clinical;Clinical Research;cytokine;Data;Development;disorder control;Event;experimental study;Exposure to;Future;hallmarks of aging;hemodynamics;Homeostasis;Human;In Vitro;in vivo;Individual;Inflammation;Inflammatory;interest;Intracranial Aneurysm;Laboratories;Link;Mediating;mitochondrial dysfunction;Modeling;mortality;Mus;new therapeutic target;old mice;paracrine;Pathologic;Patients;Pharmaceutical Preparations;pharmacologic;pre-clinical;preclinical study;premature;prevent;Prevention;pro-aging;Procedures;Proteomics;Reactive Oxygen Species;Risk;Risk Factors;Role;Rupture;Ruptured Aneurysm;screening;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Severities;sex;Sex Differences;Stress;Subarachnoid Hemorrhage;Surgical Clips;targeted treatment;Testing;tissue repair;Tissues;Transgenes;young adult

PROJECT_TITLE: Roles of aging and cellular senescence in the development of intracranial aneurysm rupture

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CN-T(90)M]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Genetics;Mental Health;Mental Illness;Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The aim of this simultaneous positron emission tomography-magnetic resonance imaging (PET-MRI) study is to quantify the relationship between histone deacetylase (HDAC) expression, socio-emotional behavior assessed using self-report questionnaires, and brain activation in response to functional MRI tasks in young healthy adult males and females.

PI_NAMEs: ZURCHER WIMMER, NICOLE R (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Adult;Adult women;Affect;Anhedonia;Animals;Anxiety;Area;autism spectrum disorder;Autopsy;Behavior;Behavior assessment;behavioral construct;behavioral phenotyping;behavioral study;Binding;Brain;Code;cohort;Communication;Data;Deacetylation;Development;Disease;Disease susceptibility;DNA;Drug Addiction;emotion regulation;Emotional;emotional behavior;Emotions;Environment;Environmental Risk Factor;Enzyme Repression;Enzymes;Epigenetic Process;epigenetic variation;Etiology;Exhibits;experience;Family;Female;Functional disorder;Functional Magnetic Resonance Imaging;Future;Gene Expression;gene repression;General Population;Genetic Transcription;Goals;HDAC1 gene;HDAC6 gene;Histone Deacetylase;Histone Deacetylase Inhibitor;Histone Deacetylation;Human;imaging probe;imaging study;improved;in vivo;in vivo imaging;insight;interest;Investigation;Link;Lysine;Magnetic Resonance Imaging;male;Measures;Mediating;Mental Depression;Mental disorders;Nature;Neuropsychology;Normal Statistical Distribution;novel;Participant;Patient Self-Report;Pharmaceutical Preparations;Play;pleasure;Positron-Emission Tomography;pre-clinical;preclinical study;Prevalence;Process;psychologic;Publishing;Questionnaires;radioligand;Research Domain Criteria;response;reward processing;Rewards;Rodent Model;Sampling;Self Administration;sex;sex as a biological variable;Sex Differences;sexual dimorphism;skills;small molecule;social skills;Standardization;symptomatic improvement;Symptoms;Tail;Testing;trait;uptake;Variant;Work;young adult

PROJECT_TITLE: Epigenetic involvement in socio-emotional behavior studied by PET- MRI

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Rare Diseases

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: Project Narrative The human GlcNAc-1-phosphotransferase catalyzes a key step in covalently tagging the mannose-6- phosphate (M6P) signal to the lysosomal hydrolases, thereby targeting these hydrolases to lysosomes. Mutations in the encoding genes GNPTAB and GNPTG cause the lysosomal storage disorders mucolipidosis II and mucolipidosis III and are directly associated with neurological and neurodegenerative disorders. Our work will provide mechanistic insights into the enzyme catalysis and into how mutations in the enzyme cause the associated diseases.

PI_NAMEs: LI, HUILIN  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: 3-Dimensional;Acids;Active Sites;Address;Affect;autism spectrum disorder;Binding;Biochemical;Biological Assay;Catalysis;Catalytic Domain;chemical reaction;conformational conversion;Cryoelectron Microscopy;Data;Dementia;design;dimer;Disease;disease-causing mutation;EF Hand Motifs;enzyme activity;Enzymes;flexibility;Genes;Glycobiology;Glycoproteins;glycosylation;Goals;Golgi Apparatus;Hockey;Holoenzymes;Human;human disease;Hydrolase;Hyperactivity;I-Cell Disease;In Vitro;in vitro activity;in vitro Assay;in vivo;insight;Intellectual functioning disability;Link;Lipids;Location;lysosomal proteins;Lysosomes;Mannose;mannose 6 phosphate;Mannosides;Maps;Membrane;Mental Retardation;Metabolic Diseases;methyl mannoside;Modeling;Molecular;Mutagenesis;mutant;Mutate;Mutation;Nervous System Disorder;Neurodegenerative Disorders;novel;Pathologic;Peripheral;Phosphorylation;Phosphotransferases;Polysaccharides;Proteins;Pseudo-Hurler Polydystrophy;Reaction;recruit;Reporting;Research;Resolution;Series;Signal Transduction;Sorting;Structure;System;Transferase;Universities;Vertebrates;Washington;Work

PROJECT_TITLE: Molecular mechanisms for sorting lysosomal proteins

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PHILADELPHIA

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Loss or collapse of narrow tubes contributes to lung, kidney and heart disease, and to stroke, blindness and age-related dementia. These studies investigate how narrow tubes are built and how a sugar- and fat-rich lining helps protect the tubes from collapse. Understanding these mechanisms will help in the design of therapies to prevent or treat tube-related disease.

PI_NAMEs: SUNDARAM, MEERA  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Affect;age related;Animal Model;Animals;Apical;Biological;Blindness;Blood capillaries;Caenorhabditis elegans;Cell fusion;Cells;Dementia;Disease;Epithelium;Event;Extracellular Matrix;Family;Fatty acid glycerol esters;follow-up;Genes;genetic approach;Glycoproteins;Heart Diseases;human disease;Image;Individual;Intracellular Membranes;Kidney Diseases;Laboratory Study;Leucine-Rich Repeat;Lipids;Lung Diseases;Mediating;Membrane;Modeling;Mucins;Nematoda;Nidogen;Organism;Pathway interactions;Plasminogen;prevent;programs;Proteins;Research;Resolution;Role;scavenger receptor;Shapes;Stroke;Structure;sugar;Surface;Testing;therapy design;trafficking;Tube;Work;Zona Pellucida

PROJECT_TITLE: Building and shaping narrow epithelial tubes in C. elegans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: KANSAS CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: NARRATIVE Our program seeks to train dual degree physician-scientists who will address important research questions related to disease and translate their research discoveries into strategies for disease prevention and therapy. Trainees supported by this award will lead the biomedical research work force, help elucidate the underlying pathogenesis of diseases, and serve patient populations suffering from complex diseases through development of innovative therapies.

PI_NAMEs: FIELDS, TIMOTHY A (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TITLE: Kansas Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Study of the evolution of the immune system permits an view of those characteristics of immunity that are vital for defense in all animals, including humans, versus those features that are “primitive” or specific to particular species. Our research in comparative immunology gives an overall view of immune molecules, such as the major histocompatibility complex (MHC) molecules, that are required to combat infectious diseases and cancer and avoid autoimmunity. We have detected MHC molecules in sharks, the oldest animals with adaptive immunity, that are likely the forerunners of their human counterparts. We will examine the structure and function of these molecules to gain insight into their functions in humans.

PI_NAMEs: ADAMS, ERIN JUNE;FLAJNIK, MARTIN F (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;adaptive immunity;Address;Affinity;Amphibia;analog;Animals;Antibodies;antigen binding;Antigen Receptors;Area;Autoimmunity;Back;Binding;Binding Sites;Biochemical;Biochemistry;Biology;biophysical analysis;Biophysics;Birds;CD1 Antigens;Cells;Characteristics;Chimera organism;Chondrichthyes;combat;Communicable Diseases;comparative;Complement;Complex;Cytomegalovirus;Data;Docking;Drug or chemical Tissue Distribution;Elasmobranchii;Evolution;experience;Explosion;Family;Fire - disasters;Fishes;follow-up;Gene Family;Genes;Genetic;Genetic Polymorphism;Genetic study;Genome;Head and neck structure;HIV;Human;Human Characteristics;Humoral Immunities;Hydrophobicity;Immune;Immune Sera;Immune system;Immunity;Immunoglobulin Somatic Hypermutation;Immunoglobulins;Immunology;in silico;In Situ Hybridization;insight;Jaw;Knowledge;Ligands;Link;Lipid Binding;Lymphocyte;Major Histocompatibility Complex;Malignant Neoplasms;member;MHC Class I Genes;Modeling;Modification;Molecular;Monoclonal Antibodies;Multigene Family;nanobodies;Natural Killer Cells;Osteichthyes;Pathway interactions;Peptide Leader Sequences;Peptides;Phylogenetic Analysis;Preparation;Property;Proteins;public health relevance;Publishing;Qa-1 Antigen;Reagent;receptor;Recombinant Proteins;Recombinants;Regulation;Reptiles;Research;Research Personnel;response;Shark;single cell analysis;Stains;Stress;Structural Biologist;Structural Models;Structure;System;T-Cell Receptor;Technology;TikTok;Tissues;transcriptome;Up-Regulation;Vertebrates;Work;X-Ray Crystallography

PROJECT_TITLE: Determining the Origins of Nonclassical Class I molecules through Molecular and Functional Approaches

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Infectious Diseases;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Acute lymphoblastic leukemia (ALL) is the most common cancer in children (age 0-14 years) and has become more frequent over the years in the United States. We have found that children who have an infection with cytomegalovirus (CMV) at birth are at a high risk for ALL and will further assess the role of this infection in a novel, unprecedented study with thousands of children with and without ALL, and will assess CMV at pregnancy, birth, and ALL diagnosis, potentially identifying a validated target for prevention of ALL.

PI_NAMEs: MA, XIAOMEI ;METAYER, CATHERINE ;WIEMELS, JOSEPH LEO (contact)

PROGRAM_OFFICER_NAME: MAHABIR, SOMDAT

PROJECT_TERMS: Accounting;Acute Lymphocytic Leukemia;Affect;Age;Archives;ARG2 gene;Attention;Birth;Birth Order;Birth Weight;Blood specimen;Bone Marrow;cancer genome;cancer type;Cells;Cesarean section;Child;Childhood;Childhood Acute Lymphocytic Leukemia;Confidence Intervals;Congenital Abnormality;congenital hearing loss;cytokine;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Vaccines;Data;data registry;Defect;Diagnosis;Enzymes;Epidemiology;epidemiology study;Ethnic Origin;Ethnic Population;Etiology;Face;Female of child bearing age;Genes;Genetic Predisposition to Disease;Genome;Goals;Health;Hematologic Neoplasms;High birth weight infant;High Prevalence;high risk;Immune;Immune response;Immune system;Immunologic Markers;immunoregulation;improved;in utero;Incidence;Infection;Infection Control;innovation;Intervention;intrauterine infection;Laboratories;Latino;Latino Population;leukemia;leukemogenesis;Life;Link;Malignant Childhood Neoplasm;Measures;Mediating;Medical Records;Mental Retardation;Microcephaly;Mutation;Natural History;Neonatal;neoplasm registry;Neurological outcome;Newborn Infant;non-genetic;novel;Odds Ratio;Outcome;Parental Ages;Pattern;Phenotype;Point Mutation;polygenic risk score;population based;Population Study;Pregnancy;Pregnant Women;prevent;Prevention;Public Health;racial population;recombinase;Relative Risks;Research;Resources;Risk;Risk Factors;Role;Sensorineural Hearing Loss;Seroprevalences;Somatic Mutation;study population;Survivors;Sweden;Techniques;Testing;treatment effect;tumor;tumor diagnostic;Tumor Tissue;United States;Vaccination;Viral;Virulence Factors;Virus;Virus Diseases

PROJECT_TITLE: Cytomegalovirus as an etiologic and clinico-pathogenic factor in childhood acute lymphoblastic leukemia

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Project Narrative This proposal explores untapped potential for turning water network perturbations from a nuisance into an exploitable reporter of protein-ligand interactions. The work will re-define structural water features using variable temperature crystallography and implement a smooth, experimental water term into computational docking to distinguish and selectively target highly similar protein isoforms. By using a water-centric approach at physiological temperature we can overcome current limitations of protein-centric, cryogenic approaches that have failed to produce an FDA approved drug for disease-promoting molecular chaperones despite decades of intense research.

PI_NAMEs: FISCHER, MARCUS  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Affinity;Area;Binding;Binding Proteins;Binding Sites;Biological;Biology;cryogenics;Crystallography;design;Disease;Docking;drug discovery;Evolution;FDA approved;fitness;flexibility;Freezing;Goals;Hydration status;Image;improved;Life;Ligand Binding;Ligands;Link;Liquid substance;Molecular Chaperones;Morphologic artifacts;Mutation;neglect;novel;Pharmaceutical Preparations;Physiological;Productivity;Protein Conformation;protein data bank;protein function;Protein Isoforms;protein protein interaction;protein structure;Proteins;Reporter;Reporting;Research;Resistance;response;Role;Structure;success;Temperature;Testing;Water;Work

PROJECT_TITLE: Exploiting Water Network Perturbations in Protein Binding Sites

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: The proposed research programs are relevant to public health because the systematic assembly of many genome editors will produce a greater understanding of the biological processes controlling genome editing inside human cells and tissues. Robust genome editing techniques could enable the production of personalized drugs, cell therapies and gene therapies for future genomic and precision medicine. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to laying the foundation for advances in disease diagnosis, treatment, and prevention.

PI_NAMEs: SAHA, KRISHANU  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Award;Biological Process;Cell Cycle Arrest;Cell Therapy;Cells;Chromatin Structure;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Development;Disease;disease diagnosis;DNA;DNA Double Strand Break;DNA Repair;Foundations;Future;gene correction;Gene Modified;gene therapy;Generations;Genes;Genome;genome editing;genome editor;Genomic medicine;Human;Image;improved;In Situ;In Vitro;induced pluripotent stem cell;innovation;Knowledge;Methods;Mission;Monitor;Morphogenesis;Mutation;novel;Operative Surgical Procedures;particle;patient - derived stem cells;Patients;pluripotent stem cell differentiation;Polymers;precision drugs;precision medicine;Prevention;Process;Production;Productivity;programs;Public Health;Research;RNA;small molecule;stem cells;Techniques;Testing;Therapeutic;Time;time use;Tissue Therapy;Tissues;tool;trafficking;United States National Institutes of Health

PROJECT_TITLE: Assembly of Novel Gene Editing Particles to Understand Genome Surgery in Patient-Derived Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Genetics;Human Genome;Pediatric

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: RELEVANCE TO PUBLIC HEALTH The Jackson Laboratory proposes to initiate, with partners in higher education, a multi-state teacher education program to provide genomics, bioinformatics and bioethics instruction to students preparing to enter the teaching profession. By targeting pre-service educators and expanding our online content, we hope to reach a broad audience of future and current educators that will expand genomic and health literacy in high schools across the US, with the ultimate goal of strengthening the future STEM workforce.

PI_NAMEs: WOJISKI, SARAH ;WRAY, CHARLES G (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: 3-Dimensional;Area;Behavior;Bioethics;Bioinformatics;bioinformatics tool;Biological Assay;Biological Sciences;career;case-based;Collaborations;Common Core;course development;Data;Data Analyses;data literacy;Data Science;design;Development;Educational Curriculum;Educational Models;Educational process of instructing;efficacy study;ethical, legal, and social implication;Ethics;Evaluation;Exercise;experience;Faculty;Future;Future Teacher;Generations;Genes;Genetic;Genetic Research;Genome;Genomics;Genotype;Goals;health literacy;high school;High School Faculty;High School Student;higher education;Informatics;innovation;Institution;Instruction;instrument;interdisciplinary curriculum;interest;Internships;Intervention;Knowledge;Laboratories;Learning;mathematical sciences;Mathematics;mathematics content;Mentors;Methods;Modality;Modernization;Molecular Genetics;Next Generation Science Standards;online course;online resource;Participant;personalized medicine;Persons;Population;Positioning Attribute;Process;Program Development;programs;Public Health;Reading;Research;Resources;satisfaction;Science;science teacher;Science, Technology, Engineering and Mathematics Education;Secondary Schools;Self Efficacy;self-directed learning;Services;skills;statistics;STEM career;student training;Students;Surveys;teacher;Teacher Professional Development;Technology;Testing;The Jackson Laboratory;Training;United States National Institutes of Health;Validation;web site

PROJECT_TITLE: Teaching the Genome Generation: Cultivating High School Genomics through Teacher Education

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE: This technology development proposal will develop novel tools to study immune responses against HIV at the single cell level. Specifically, this work will use DNA-bar-coding methodology to build reagents capable of resolving immune responses to differing molecular structures of the HIV virus. These methods will accelerate the discovery of effective antibodies against HIV, and enable rapid identification of structures of the virus against which the immune system is most effective.

PI_NAMEs: BOSINGER, STEVEN EDWARD (contact)

PROGRAM_OFFICER_NAME: PALIN, AMY COLLEEN

PROJECT_TERMS: Acceleration;Address;Algorithms;Antibodies;antigen-specific T cells;Antigens;B-Lymphocytes;Bar Codes;Benchmarking;Bioinformatics;Biological Assay;Cells;Clinical Research;Communities;Data;Development;Dissection;DNA;Epigenetic Process;Epitopes;Funding;Gene Expression;Genetic Transcription;Genotype;Goals;Grant;HIV;HIV Envelope Protein gp120;HIV Infections;HIV vaccine;immune function;Immune response;Immune system;Immunity;Immunoglobulin Genes;Immunology;in vivo;Individual;Measures;Mediating;Membrane Proteins;Methodology;Methods;Modality;Modernization;Molecular Structure;monomer;multimodality;neutralizing antibody;new technology;novel;Oligonucleotides;Patients;Productivity;protein expression;Reagent;receptor;Research;Resolution;response;Series;single cell genomics;single cell technology;single-cell RNA sequencing;Specificity;Structure;Surface;System;T cell response;T-Cell Immunologic Specificity;T-Lymphocyte;Technology;technology development;tool;transcriptome;transcriptomic profiling;transcriptomics;vaccine platform;Vaccinee;Vaccines;Validation;Viral;Viral Genome;Virus;Work

PROJECT_TITLE: Development of multi-modal single-cell technology to dissect epitope specificity to HIV


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative The Smc5/6 complex is a conserved protein complex whose roles in genome replication, DNA repair, and suppression of extra-chromosomal DNA underlie its clinical functions of tumor suppression and repression of tumor-causing viruses. To address the mechanistic knowledge gap of how Smc5/6 operates as a molecular machine, this proposal aims to: (1) characterize Smc5/6’s ability to manipulate and compact DNA; (2) elucidate the binding preferences of Smc5/6 on DNA substrates of different topologies; and (3) define Smc5/6’s interactions with DNA replication factors. Completion of this project will contribute fundamental knowledge to how cellular systems maintain genome integrity and advance the prospect of establishing Smc5/6 as a therapeutic target to treat cancer and viral infections.

PI_NAMEs: CHANG, JEREMY TZU-HUAI (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Address;Affect;Architecture;Atomic Force Microscopy;barrier to testing;Behavior;Binding;Biological Assay;Biology;biophysical properties;Body of uterus;career;Chromosomes;Clinical;cohesin;Collaborations;Color;combinatorial;Complex;condensin;Confocal Microscopy;Data;Defect;Detection;Dissection;DNA;DNA Repair;DNA Replication Factor;DNA replication fork;Doctor of Philosophy;ds-DNA;Endometrial Carcinoma;Eukaryota;Exhibits;experimental study;extrachromosomal DNA;Family;Fellowship;Fluorescence;Fluorescence Microscopy;Genome;genome integrity;Genomic Instability;Goals;Health;helicase;Hepatitis B Virus;human disease;Human Papillomavirus;In Vitro;in vivo;Individual;innovation;insight;Institution;Knowledge;Label;laser tweezer;Literature;Maintenance;Malignant - descriptor;Malignant Neoplasms;Measures;Mediator;melting;member;Mentorship;Microfluidics;Molecular;molecular dynamics;Molecular Machines;Monitor;Movement;Mutation;novel strategies;novel therapeutic intervention;operation;optic trap;optic tweezer;optical traps;Outcome;Physiological;Play;Polymerase;Positioning Attribute;preference;programs;Property;protein complex;Publishing;Reaction;reconstitution;replication stress;Repression;Research;Research Personnel;Resolution;restraint;Role;Scientist;single molecule;Single-Stranded DNA;Students;System;Technology;Testing;therapeutic target;Time;Training;translocase;tumor;Tumor Suppression;Tumor Suppressor Proteins;Universities;Virus;Virus Diseases;Work

PROJECT_TITLE: Single-molecule dissection of a tumor- and virus-suppressing Smc complex involved in genome maintenance


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Mental Health;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Our project will examine how the COVID-19 pandemic impacted children’s health and education in NYC over time, using a set of linked administrative data from multiple domains and including all children enrolled in the public school system. We will determine how racial/ethnic and income disparities were affected, in particular how vaccine availability and uptake, as well as school and neighborhood resources altered outcomes and disparities.

PI_NAMEs: ELBEL, BRIAN  (contact);SCHWARTZ, AMY ELLEN

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Absenteeism;Academic achievement;access disparities;Affect;Age;Anxiety;Asian;Asthma;Authorization documentation;Behavioral;Black race;Body mass index;Buffers;Characteristics;Child;Child Health;Chronic;Chronic Disease;cohort;Color;Communities;COVID-19;COVID-19 disparity;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 vaccination;Data;Data Sources;Development;Diabetes Mellitus;Diet;Disparity;Disparity population;Economics;Education;elementary school;Emergency Situation;Enrollment;ethnic disparity;Ethnic Origin;Event;Food;food resource;Health;health disparity;Health Services;Health system;Healthcare;high school;Hispanic;Immunization;Incidence;Income;income disparities;Individual;insight;Learning;Life Cycle Stages;Link;longitudinal database;Low income;Measures;Medicaid;member;Mental Health;Mental Health Services;Modern 1601-history;Municipalities;Neighborhoods;New York City;Obesity;Outcome;outcome disparities;pandemic disease;pandemic impact;Personal Satisfaction;Persons;Physical activity;population health;post-COVID-19;pre-pandemic;public health priorities;Race;racial disparity;Records;Registries;Research;resilience;Resources;Risk;Role;School Drop-Outs;Schools;Services;Shapes;Site;social;Social Impacts;Source;Special Education;Stress;Student Dropouts;Students;Surveys;System;Testing;Time;United States;Vaccination;vaccine acceptance;vaccine access;Vaccines;Variant

PROJECT_TITLE: COVID-19 Vaccinations and School / Community Resources: Children's Longitudinal Health and Education Outcomes Using Linked Administrative Data


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Pediatric;Regenerative Medicine;Transplantation

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: NARRATIVE: Diseases that impact facial development are difficult to repair because a large source of skeletal tissue is often necessary. Our research program studies the cells that give rise to the facial skeleton (neural crest cells) and tries to direct their differentiation into skeletal tissues amenable for surgical repair.

PI_NAMEs: BRUGMANN, SAMANTHA A (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Allografting;Biochemical;bone;Bone Transplantation;Cell Differentiation process;Cell Proliferation;Cells;Cilia;ciliopathy;Congenital Abnormality;Craniofacial Abnormalities;craniofacial repair;Development;Disease;Embryo;Face;Goals;Knowledge;Laboratories;Molecular;Nature;Neural Crest Cell;neuromechanism;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Organelles;Population;postnatal;programs;repaired;Research;Signal Transduction;skeletal tissue;Skeleton;Source;Therapeutic;Tissue Engineering;Tissues;United States;Work

PROJECT_TITLE: Harnessing the therapeutic potential of neural crest cells by manipulating the primary cilium


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Genetics;Major Depressive Disorder;Mental Health;Mental Illness;Pediatric;Serious Mental Illness;Social Determinants of Health;Suicide;Violence Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Childhood maltreatment is a major risk factor for suicidal behavior; however, the molecular mechanisms by which childhood maltreatment impacts suicidality, is not known. MicroRNAs are important transducers of environmental effects on gene expression products; this work will test the effects of both childhood maltreatment and an acute experimental stressor on brain microRNAs in humans using a novel method of isolating neural-derived plasma exosomal microRNAs from peripheral blood. By examining microRNAs as mediators of childhood maltreatment- induced suicidality, this study will identify potential molecular mechanisms by which childhood maltreatment can act as a risk factor for suicidality, and neural-derived exosomal microRNAs as novel biosignature of suicide risk in the context of childhood maltreatment that can be tested in longitudinal studies.

PI_NAMEs: DWIVEDI, YOGESH  (contact);SHELTON, RICHARD CHARLES

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Acute;acute stress;Affect;Aggressive behavior;Autopsy;bioinformatics tool;Biometry;biosignature;Brain;Cell secretion;Cell surface;Characteristics;Child Abuse and Neglect;clinical phenotype;cohort;Complex;Data;DNA Methylation;Epigenetic Process;Exhibits;exosome;Feeling suicidal;Gene Expression;Gene Expression Regulation;gene network;Genes;Hostility;Human;ideation;Impulsivity;innovation;Link;Longitudinal Studies;Major Depressive Disorder;Mediator;Mental Depression;Methods;Methylation;MicroRNAs;Modification;Molecular;Molecular Profiling;neural;neural network;novel;Participant;Pathologic;Pathway interactions;Patient Recruitments;Patients;Pattern;peripheral blood;Persons;Phenotype;Plasma;Population;promoter;psychological stressor;Recording of previous events;Regulation;response;Risk;Risk Factors;Severities;Stressful Event;stressor;study population;suicidal;suicidal behavior;suicidal patient;suicidal risk;Suicide;Suicide attempt;suicide brain;Sum;Synapses;Testing;Transducers;Trier Social Stress Test;Work

PROJECT_TITLE: MicroRNA Correlates of Childhood Maltreatment and Suicidality

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative The proposed studies will explore a novel mechanism of astrocytic modulation of synaptic plasticity involving norepinephrine (NE) and ATP. Since NE is known to play an important role in many pathophysiological disorders such as ADHD, depression, epilepsy, and Alzheimer’s disease, these studies may also give new insight into the role that astrocytes play in neurological disease. Illuminating the importance of this novel mechanism of astrocytic modulation of synaptic plasticity may reveal pathways suitable for pharmacological manipulation to treat diseases of the central nervous system.

PI_NAMEs: SMITH, NATHAN A (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acute;Adrenergic Agents;Adrenergic Receptor;Adult;Alzheimer's Disease;antagonist;Astrocytes;Attention;Attention deficit hyperactivity disorder;authority;Biology;Biomedical Research;Brain;Buffers;Carbenoxolone;career development;Central Nervous System Diseases;Child;Connexin 43;Data;Development;Disease;Endoplasmic Reticulum;Environment;Epilepsy;executive function;extracellular;Faculty;Feedback;Functional disorder;Gap Junctions;Glutamates;Goals;Health;Health Sciences;Health system;Hippocampus;In Vitro;in vivo;in vivo imaging;information processing;inhibitor;Inositol;insight;Institution;Investigation;K-Series Research Career Programs;Knockout Mice;Learning;Learning Disorders;locus ceruleus structure;Long-Term Depression;Mediating;medical schools;Memory;Memory Disorders;Mental Depression;Mentored Research Scientist Development Award;Mentors;Mentorship;metabotropic glutamate receptor 3;Modeling;Mus;Nervous System Disorder;Neuroglia;Neuromodulator;neuronal circuitry;Neurons;neuropsychiatric disorder;neuroregulation;neurotransmission;Neurotransmitters;Norepinephrine;novel;Patch-Clamp Techniques;Pathway interactions;Pediatrics;Peptides;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physiology;Play;Potassium;Preparation;Process;professor;programs;Protocols documentation;receptor;Regulation;Research;Research Personnel;Role;Sensory;Serine;Shapes;Short-Term Memory;Signal Transduction;skills;Slice;SNAP receptor;Somatosensory Cortex;Stimulus;Synapses;Synaptic plasticity;Techniques;terazosine;Testing;therapeutically effective;Training;tripolyphosphate;Universities;vesicular release;Visual Cortex;Washington

PROJECT_TITLE: Astrocytes Modulate Synaptic Plasticity via Norepinephrine


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: The goal of this CBI training program is to develop next generation leaders of chemical biologists who will tackle the most significant scientific questions, with particular focus on topics in molecular probe and drug discovery. This program leverages the unique research and educational environment at the University of Florida to provide graduate students from medicinal chemistry, chemistry, biochemistry, biology, biomedical sciences and chemical engineering knowledge, skills and career development opportunities to work together collaboratively in interdisciplinary teams. Students will be trained as experts on both chemistry and biology knowledge domains and can make an impact on health-related research needs.

PI_NAMEs: LI, CHENGLONG  (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TITLE: Chemistry-Biology Interface Training Program at the University of Florida


NIH_SPENDING_CATS: HIV/AIDS;Mental Health

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative There is an urgent need to increase the diversity of independent investigators both generally and in HIV-related behavioral health research in particular. Miami is an HIV epicenter, with new diagnoses disproportionately impacting underrepresented racial and ethnic minorities. The proposed (CHANGE; Culturally-focused HIV Advancements through the Next Generation for Equity) training program, tied to the University of Miami’s Center for HIV and Research in Mental Health (CHARM), will fill this gap by training underrepresented Black and Latinx predoctoral and post-doctoral behavioral scientists in research related to HIV and mental health disparities, aligned with the NIH NOT-OD-20-031 on diversity.

PI_NAMEs: DALE, SANNISHA K.;FEASTER, DANIEL J (contact);HORIGIAN, VIVIANA ELIZABETH

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TITLE: Culturally-focused HIV Advancements through the Next Generation for Equity (CHANGE) Training Program


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Mental Health;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE The proposed K99/R00 study will use a clinical nutrition intervention trial in rural Ethiopia to determine interactive effects of maternal prenatal stress and nutrition intervention on newborn weight-for-age and stress-sensitive child outcomes related to visual attention, memory, stress reactivity, and socio-emotional functioning at 36 months postpartum. We will also examine whether maternal and newborn telomere length serves as biomarkers of the biologic mechanism underling hypothesized associations. Insight from this project will cast light on the importance of antenatal intervention to reduce commonly co-occurring maternal prenatal stress and undernutrition among millions of women residing in low- resource settings.

PI_NAMEs: JENSEN, SARAH KATHINKA GEORG (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Acceleration;Achievement;Adverse effects;Affect;antenatal;antenatal care;Attention;Award;Basic Science;behavior test;Biological;Biological Factors;Biological Markers;Biology;Birth;Birth Weight;Blood;career;Cell Aging;Cells;Child;Child Behavior Checklist;Child Development;Child Support;Childhood;Chromosomes;Clinical Nutrition;Complex;Data;Data Collection;Development;Dietary Intervention;Dryness;Electrocardiogram;emotional functioning;energy balance;Epidemiology;Ethiopia;Exposure to;fetal;Fetal Development;Fetal Growth;fetal programming;fetus nutrition;Folic Acid;Follow-Up Studies;Fortification;Future;Genome;Goals;heart rate variability;implementation science;improved;in utero;Infant;Infection;Inflammation;innovation;insight;Interdisciplinary Study;Intervention;Intervention Trial;iodized salt;Iron;Knowledge;Knowledge acquisition;Lead;Length;Light;Link;Low Birth Weight Infant;low income country;Malnutrition;Maternal and Child Health;maternal stress;Mediating;Memory;Mental Health;mother nutrition;Mothers;National Institute of Child Health and Human Development;Neurosciences;Neurosecretory Systems;Newborn Infant;Nutrient;nutrition;offspring;Outcome;Oxidative Stress;perceived stress;Physiology;Positioning Attribute;postnatal;Postpartum Period;Poverty;Pregnancy;Pregnancy Outcome;Pregnant Women;prenatal;prenatal exposure;Prenatal Nutrition;prenatal stress;primary outcome;Proteins;Psychological Stress;Psychopathology;Psychosocial Factor;Public Health;public health relevance;Randomized;Research;research study;Resource-limited setting;Role;Rural;Schools;Shapes;skills;Spottings;standard care;Stress;stress reactivity;Tandem Repeat Sequences;Technical Expertise;telomere;Telomere Shortening;Time;Training;Umbilical Cord Blood;Untranslated RNA;Visual attention;visual tracking;Weight;Woman;Women's Health

PROJECT_TITLE: Maternal stress and undernutrition: Interactive effects on newborn and child outcomes in Ethiopia”

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Mental Health

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative. The proposed UC Davis "Training Program in Learning, Memory, and Plasticity (LaMP)" will allow us to continue to provide training across disciplines to bridge the gaps between the major levels of LaMP research— cognitive, systems, cellular/molecular—in order to promote our understanding of LaMP disorders and reduce their tremendous burden on families, society, and public health. Using this focused, innovative Training Program, we are producing a new generation of diverse scientists who truly think across levels and scales and who have the skills, drive, and motivation to work collaboratively to tackle the most important issues in LaMP in order to improve human health.

PI_NAMEs: ZITO, KAREN  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Learning;Memory;Training Programs

PROJECT_TITLE: Learning, Memory, and Plasticity (LaMP) Training Program


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Infant Mortality;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: PEDIATRICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE This is relevant to public health because it seeks to identify modifiable factors in very preterm infant growth, nutrition, social and environmental exposures, and illness to optimize long-term abilities and health outcomes. The established link between very preterm infant growth and neurodevelopmental outcomes likely represents a combination of nutrient intake, illness prevention, and social support that promotes growth and brain development. Up to 30% of very preterm infants continue to experience motor, learning, behavior problems, and/or cognitive impairment; identifying opportunities for positive interventions is critical to ensuring these infants have every opportunity for an optimal life.

PI_NAMEs: MARTIN, CAMILIA R;TAYLOR, SARAH N (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: 2 year old;Admission activity;Age;Biological;Birth;Body Composition;Brain;Caring;Classification;Clinical;clinical care;Clinical Trials;cohort;Collection;Coupled;Data;Detection;Development;Dietary Intervention;Dimensions;Enrollment;Ensure;Environmental Exposure;Environmental Risk Factor;Exhibits;expectation;experience;extreme prematurity;fetal;Fetal health;Fostering;Future;Gestational Age;Growth;Health;health determinants;Health Status;Hospitals;Impaired cognition;infancy;Infant;Infant Care;Infant Development;Infant Health;infant outcome;Intake;Intervention;Intervention Trial;Investigation;Knowledge;Lead;Learning;Life;Link;Longitudinal cohort study;Maternal Health;Measures;Mediating;Metabolism;Methodology;Micronutrients;Modeling;Motor;Neonatal;neonatal health;Neonatal Intensive Care Units;Nutrient;nutrition;Nutritional;Nutritional Study;operation;Outcome;outcome prediction;Pattern;Phenotype;Population;Population Intervention;postnatal;Pregnancy;Premature Infant;Prevention;Problem behavior;prospective;Prospective, cohort study;Public Health;Recurrence;repository;Research;Research Personnel;Role;Sampling;Sentinel;social;social determinants;social health determinants;Social support;sociodemographics;socioenvironmental factor;Time;Work

PROJECT_TITLE: Phenotypic Driven Growth Trajectories in Very Preterm Infants to Define Nutritionally Mediated Health Outcomes and Modifiable Targets


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Genetics;Hematology;Infectious Diseases;Physical Injury - Accidents and Adverse Effects;Sepsis

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PUBLIC HEALTH RELEVANCE STATEMENT: One of the main causes of death after massive radiation exposure is infection. In this project, we will study the role of a novel protein, extracellular cold-inducible RNA- binding protein (eCIRP), on the reduced removal of bacteria by macrophages after radiation exposure, determine the detailed mechanisms by which this occurs and, importantly, develop a new drug able to revert the eCIRP-induced macrophage defect, thereby attenuating radiation injury and infection. This project aims at establishing the importance of suppressing eCIRP to control infection after radiation injury and developing a new way to protect people from the harmful effects of massive radiation exposure alone or complicated by sepsis.

PI_NAMEs: AZIZ, MONOWAR ;BRENNER, MAX ;WANG, PING  (contact)

PROGRAM_OFFICER_NAME: WINTERS, THOMAS A

PROJECT_TERMS: Actins;Acute;Affect;Bacteria;Bacterial Counts;Bacterial Infections;Binding;Binding Proteins;Blood;Cause of Death;Cells;Cessation of life;Cytoskeletal Modeling;Cytoskeletal Proteins;Cytoskeleton;Defect;Dose;Drug Kinetics;Escherichia coli;Excision;Exposure to;extracellular;FDA approved;Filgrastim;Filopodia;gain of function;Greater sac of peritoneum;Human;Immune response;Immune System Diseases;Impairment;improved;In Vitro;in vivo;Infection;Infection Control;inhibitor;insight;Invaded;Ionizing radiation;Knock-out;Kupffer Cells;loss of function;Macrophage;Mediating;Mediator;medical countermeasure;mesenteric lymph node;Molecular;Mus;Myeloid Cells;neutrophil;novel;novel therapeutics;Nuclear power plant accident;Paralysed;Pathogenesis;Pathway interactions;Pattern;Peptide Hydrolases;Peritoneal Macrophages;Peroxidases;Persons;Phagocyte Bactericidal Dysfunction;Phagocytes;Phagocytosis;Play;polymerization;Polymers;protein activation;Proteins;Proteomics;public health relevance;Radiation;Radiation Dose Unit;radiation effect;Radiation exposure;Radiation Injuries;receptor;restoration;Risk;RNA-Binding Proteins;Role;Sepsis;Severities;STAT1 protein;Stat3 protein;Terrorism;Therapeutic;Time;Tissues;Toxicology;Whole-Body Irradiation;Wild Type Mouse

PROJECT_TITLE: Mechanisms of Radiation-Induced Innate Immune Dysfunction and Its Countermeasures


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: DNA replication is the process whereby the genome is duplicated prior to segregation of the resulting sister chromatids during mitosis or meiosis. During mitotic exit or during G1 phase, a pre-Replicative Complex is assembled each at origin of DNA replication throughout the genome that renders each origin competent for subsequent initiation of DNA replication, including assembly of a pre-Initiation Complex. This project will examine how the initiation of DNA replication occurs and how it is regulated, including studies at the structural and single cell level.

PI_NAMEs: STILLMAN, BRUCE W. (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Affect;Animals;Applications Grants;Area;Aspergillus;Award;Binding;Binding Proteins;Biochemistry;biological adaptation to stress;Biological Models;Biological Process;cancer cell;Cell Cycle Regulation;Cell division;Cell Lineage;Cells;Chromatin;Chromatin Structure;Chromosomes;comparative;Complex;daughter cell;Dependence;Diagnosis;Disease;DNA;DNA biosynthesis;DNA Replication Factor;DNA replication fork;DNA replication origin;DNA Sequence;DNA Sequence Alteration;Epigenetic Process;Eukaryota;Eukaryotic Cell;Fission Yeast;follow-up;Funding;fungus;G1 Phase;Gene Silencing;Generations;Genes;Genome;genome integrity;genome-wide;Genomic Instability;Germ Lines;Goals;Heterochromatin;Human;Inherited;insight;Interruption;Laboratories;Life;Location;Maintenance;Malignant Breast Neoplasm;Maps;MCM2 gene;Measurement;Meiosis;Mitosis;Mitotic;Modeling;Mutation;Nature;Neoplastic Cell Transformation;Neurospora;origin recognition complex;Pathway interactions;Pattern;Phosphotransferases;Plants;Postdoctoral Fellow;Process;Proliferating;promoter;protein complex;Proteins;reconstitution;Regulation;Replication Initiation;Replication Origin;Request for Applications;Research;Research Support;Role;Saccharomyces cerevisiae;Saccharomycetales;segregation;Series;Sister Chromatid;Somatic Cell;Specific qualifier value;Stress;Structure;Students;System;targeted treatment;Therapeutic Intervention;Work;Yarrowia;Yarrowia lipolytica;Yeasts

PROJECT_TITLE: Initiation of DNA Replication at Cell Origins in Yeast

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Services

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Individuals with voice disorders often suffer from heightened sensations of vocal effort and fatigue while speaking that are typically attributed to inefficient vocal function and behavior. The proposed project seeks to investigate a new index of ambulatory vocal efficiency that integrates estimates of subglottal pressure and vocal sound pressure level to monitor the vocal effort of patients being treated for phonotraumatic vocal cord lesions, non- phonotraumatic vocal hyperfunction, and unilateral vocal fold paralysis. The impact of this work is significant as the new index of ambulatory vocal efficiency will substantially improve the assessment and treatment of voice disorders by providing the capability to quantify a clinically salient vocal parameter in real-world situations.

PI_NAMEs: MEHTA, DARYUSH DINYAR (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TITLE: Ambulatory monitoring of a vocal efficiency index to improve the clinical management of voice disorders

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Duchenne/ Becker Muscular Dystrophy;Genetics;Muscular Dystrophy;Pediatric;Rare Diseases

ORG_CITY: DAYTON

ORG_NAME: WRIGHT STATE UNIVERSITY

PHR: NARRATIVE This proposal presents pilot data showing that lipin1 is downregulated in skeletal muscle of patients with Duchenne muscular dystrophy, and that lipin1 overexpression enhances muscle membrane integrity, reduces muscle degeneration, and ameliorates muscle weakness in a mouse model of this disease. The proposed study aims to elucidate the molecular basis of how lipin1 overexpression attenuates the dystrophic pathology. This work is relevant to public health because it is expected to identify new therapeutic targets and effective treatments for Duchenne muscular dystrophy, which is the most common and severe form of muscular dystrophy, as well as additional related muscular disorders.

PI_NAMEs: REN, HONGMEI  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Activities of Daily Living;Adult;Affect;Age;age-related muscle loss;aged;Anabolism;Attenuated;Cell Death;Cell membrane;Cessation of life;ChIP-seq;Clinical;Data;Diglycerides;disability;Disease;disease model;Disease Progression;Dose;Duchenne muscular dystrophy;Dystrophin;effective therapy;Enzymes;exhaust;Gene Delivery;Gene Expression;Gene Expression Profile;gene therapy;Gene Transduction Agent;Genes;Genetic Transcription;Glycerophospholipids;Goals;improved;Individual;Intramuscular;intravenous administration;Lecithin;Lipids;lipine;Live Birth;mdx mouse;Mediating;Membrane;Methods;micro-dystrophin;Mission;Molecular;Morphology;mortality;motor deficit;mouse model;mRNA Expression;Mus;Muscle;Muscle Cells;Muscle Contraction;muscle degeneration;Muscle Fibers;Muscle function;muscle regeneration;Muscle Weakness;Muscular Atrophy;Muscular Dystrophies;mutant;myocyte-specific enhancer-binding-factor 2C;Myopathy;new therapeutic target;novel;overexpression;Pathologic;Pathology;Patients;Phase;Phenotype;Phosphatidate Phosphatase;Phosphatidic Acid;Phospholipids;Play;Predisposition;prevent;protective effect;protein expression;Protein Isoforms;Public Health;Publications;Regenerative capacity;Regimen;Research;Resistance;Rhabdomyolysis;Role;Safety;Signal Transduction;Skeletal Muscle;Specificity;Stress;Structural Genes;Teenagers;Testing;Therapeutic;tool;Transcription Coactivator;Transcriptional Regulation;transduction efficiency;Transgenic Mice;Transgenic Organisms;Treatment Efficacy;United States National Institutes of Health;Up-Regulation;Wheelchairs;Work;young adult

PROJECT_TITLE: The Role of Lipin1 in Myofiber Stability and Integrity

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;HIV/AIDS;Health Services;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: NARRATIVE We will leverage the infrastructure from ongoing studies among people living with HIV (PLWH) enrolled in Medicaid to assess the relationship between HIV and COVID among beneficiaries in 27 states and Washington, DC, including all states and counties prioritized to end the HIV epidemic. We will also evaluate the impact of the COVID-19 pandemic on the provision of HIV care across the continuum and care for health conditions. We will compare our findings by geographic location (state, urban/rural, local government area [LGA], smallest government region e.g. county, city, town, etc.), community level social determinants of health, and among sub-populations to help inform and target interventions to improve care for PLWH in the future.

PI_NAMEs: JOSHU, CORINNE E.;LAU, BRYAN  (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;acute care;acute COVID-19;Acute Disease;Adverse effects;adverse outcome;Age;AIDS prevention;Alcohols;Anti-Retroviral Agents;Area;behavioral health;beneficiary;Caring;CD4 Lymphocyte Count;Cessation of life;Cities;Clinical;Cohort Studies;combat;Communities;comorbidity;comparison group;Complement;Continuity of Patient Care;County;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 risk;COVID-19 screening;COVID-19 severity;Data;Diabetes Mellitus;Diagnosis;Disease;Enrollment;Epidemic;Ethnic Origin;Future;geographic difference;Geographic Locations;Geography;Goals;Government;Health;health care service utilization;Health Services Accessibility;Healthcare;Hepatitis C Therapy;high risk;HIV;HIV diagnosis;HIV/AIDS;Hospitalization;Human immunodeficiency virus test;Hyperlipidemia;Hypertension;improved;Incidence;Inflammatory;Infrastructure;Inpatients;interest;Intervention;Local Government;Long COVID;long term consequences of COVID-19;Medicaid;Medical;Mental Health;Operative Surgical Procedures;Outcome;Overdose;pandemic disease;pandemic impact;Persons;Pharmaceutical Preparations;Pneumonia;Policies;Population;Post-Acute Sequelae of SARS-CoV-2 Infection;pre-exposure prophylaxis;Prevention;Preventive care;Preventive screening;Probability;Public Health;Race;regional difference;remote health care;Reporting;Risk;Risk Factors;Rural;SARS-CoV-2 infection;screening;Screening for cancer;Services;severe COVID-19;sex;social health determinants;Symptoms;Syndrome;System;Telemedicine;Testing;Time;United States;uptake;Viral;Viral Load result;Visit;Washington;wellness visit;Work

PROJECT_TITLE: At the Intersection of HIV and COVID-19: Medicaid Data as a Complement to Cohort Studies

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: NARRATIVE Innate immune signaling pathways including the RIG-I-like receptor (RLR), cGAS-STING and NLRP3 inflammasome pathways play crucial roles in the host response to pathogenic microbes. These pathways are potent inducers of inflammation when triggered and must be tightly regulated to avoid overexuberant inflammation and tissue damage. This proposal will investigate the mechanisms by which the selective autophagy receptor TAX1BP1 regulates innate immune signaling and immune homeostasis.

PI_NAMEs: HARHAJ, EDWARD W (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Acute;adaptive immune response;adaptive immunity;Adaptor Signaling Protein;Agonist;Amyotrophic Lateral Sclerosis;Apoptosis;Apoptotic;Automobile Driving;Autophagocytosis;Autophagosome;CASP1 gene;Cell Death;Cell membrane;cell type;Cells;CRISPR/Cas technology;cytokine;Data;Dinucleoside Phosphates;DNA;DNA Viruses;Double-Stranded RNA;ds-DNA;Endoplasmic Reticulum;Gene Expression;Genes;genomic RNA;Goals;Golgi Apparatus;Herpesvirus 1;Homeostasis;Host Defense;Huntington Disease;IFIH1;Immune;Immune response;Immune signaling;immunoregulation;in vivo;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;innate immune pathways;insight;Interferon alpha;Interferon Type I;Interferon-beta;Invaded;Investigation;IRF3 gene;Knock-out;Knockout Mice;Lytic;Macrophage;Mass Spectrum Analysis;Mediating;Membrane;Mitochondria;Modeling;Molecular;Mus;mutant;Natural Immunity;NF-kappa B;novel;pathogen;pathogenic microbe;Pathogenicity;Pathway interactions;Pattern;Pattern recognition receptor;Periodicity;Peritoneal;Phosphorylation;Phosphorylation Site;Phosphotransferases;Play;prevent;Principal Investigator;Production;protein aggregation;Proteins;Reagent;receptor;Receptor Signaling;reconstitution;recruit;Regulation;Reporting;Research Personnel;response;RNA Helicase;RNA Viruses;Role;sensor;Signal Pathway;Signal Transduction;Signaling Protein;Specificity;Stimulator of Interferon Genes;TBK1 gene;Testing;Tissues;tool;transcription factor;Transcriptional Activation;ubiquitin isopeptidase;Viral Genome;viral genomics;virology;Virus;Work;Zinc Fingers

PROJECT_TITLE: Negative regulation of innate immune signaling pathways by the selective autophagy receptor TAX1BP1

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Social behaviors are essential for the mental and physical well-being of social species including humans; abnormalities in social behaviors are major symptoms in a host of mental disorders, such as autism spectrum disorders and psychopathy. The proposed research is relevant to public health because it studies the fundamental mechanisms that regulate an important form of social behavior. The proposed research could help reveal fundamental principles that are potentially applicable to the human brain, and could help guide investigation of disease mechanisms and development of effective treatments for human mental disorders.

PI_NAMEs: HONG, WEIZHE  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Adult;Affective;affiliative behavior;Amygdaloid structure;Animals;Area;autism spectrum disorder;awake;Axon;Behavior;Behavior Control;Behavioral;Birds;Brain;Calcium;cell type;Cells;Chiroptera;Complex;COVID-19 pandemic;Cues;Data;Development;Disease;Dissection;Distress;effective therapy;endogenous opioids;experience;experimental study;Felis catus;Female;Gene Expression;gene function;Grooming;Heterogeneity;Human;Image;Imaging Techniques;Impairment;in vivo;in vivo imaging;Individual;insight;Investigation;Laboratory mice;Life;male;Mammals;Maps;Medial;Mediating;Mental disorders;midbrain central gray substance;Molecular;Mus;neural;neural circuit;Neurons;Neuropeptides;neuropsychiatric disorder;neuropsychiatry;novel;optogenetics;Oxytocin;Pattern;Personal Satisfaction;Physiological;Play;Population;Preoptic Areas;Primates;Psyche structure;psychopathic personality;Public Health;Regulation;Reproduction;Research;Resolution;Rodent;Role;Schizophrenia;Sensory;Series;social;social attachment;Social Behavior;social cohesion;social contact;Social Interaction;Social isolation;social relationships;Social Well-Being;Stress;Structure;Subgroup;Symptoms;Techniques;Testing;therapy development;Touch sensation;transcriptomics;Ventral Tegmental Area

PROJECT_TITLE: Neural Circuit Mechanisms of Allogrooming Behavior

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Infectious Diseases;Lung;Pediatric;Rare Diseases

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: PROJECT NARRATIVE The goal of this K24 is to provide support for Dr. Ashare to spend an additional 25% of her time mentoring junior scientists in patient-oriented research on inflammatory lung disease, as well as additional time developing her own mentoring skills. This innovative and potentially paradigm shifting research in human subjects is important for public health because understanding the mechanisms underlying regional development and progression of inflammatory lung disease will have a critical impact on investigations of novel therapeutic interventions for lung diseases such CF. Furthermore, the proposed research is germane to the NIH’s mission focusing on discoveries related to human disease pathogenesis and translation of these studies to clinical medicine.

PI_NAMEs: ASHARE, ALIX  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: adaptive immune response;Advisory Committees;Award;Bronchiectasis;Cells;chemokine;chronic infection;Clinical;Clinical Medicine;Clinical Research;Cystic Fibrosis;cystic fibrosis infection;cystic fibrosis patients;cytokine;Data;Development;Disease;Doctor of Philosophy;Environment;Exhibits;extracellular;Frequencies;Funding;Generations;Genotype;Glycolysis;Goals;Heterogeneity;human disease;human subject;Hypoxia;Immune;Immune response;improved;Individual;Infection;Inflammation;Inflammatory;inflammatory lung disease;Inflammatory Response;innovation;Investigation;Junior Physician;Knowledge;Lead;Lobe;Lung;Lung Diseases;lung lobe;lung upper lobe;Macrophage;Mentors;Metabolic;metabolic profile;Metabolism;microbiota;Mission;Mucous body substance;Mutation;neutrophil;novel therapeutic intervention;pathogen;Pathogenesis;patient oriented;patient oriented research;pediatric patients;Phagocytosis;Phenotype;Physicians;Population;Production;programs;Pseudomonas aeruginosa;Public Health;Publishing;Pulmonary Cystic Fibrosis;Pulmonary Inflammation;recruit;regional difference;Research;Research Project Grants;Respiratory Failure;response;Role;Scientist;skills;Succinates;Testing;Time;time use;transcription factor;Translational Research;translational study;United States National Institutes of Health;Virulence;Virulence Factors;Work

PROJECT_TITLE: Macrophage Pathogen Interactions in Regional Cystic Fibrosis Lung Inflammation

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Nutrition

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE Experiments described in this proposal will define how dietary and immune dependent changes in the nutritional landscape in the gut drive the pathogenesis of Clostridioides difficile infection. In addition, this research will reveal how C. difficile adapts to changes in nutrient levels during infection to outcompete members of the gut microbiota. These discoveries will pave the way for the development of therapeutics or nutritional countermeasures to prevent or treat C. difficile infection which is one of the most important threats to global public health.

PI_NAMEs: SKAAR, ERIC P (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Affect;Antibiotic Therapy;Antibiotics;Bacteroides;Binding;Binding Proteins;Biological Markers;cell type;Cells;chelation;chemokine;Clinical;Clostridium difficile;cofactor;colonization resistance;Complex;cost;cytokine;Data;defined contribution;Development;dietary;dietary excess;Dietary Zinc;enteric infection;enteric pathogen;Event;experimental study;gastrointestinal epithelium;Gastrointestinal tract structure;Gene Expression;gene product;Genes;Genetically Modified Animals;Growth;gut colonization;gut microbiota;host-microbe interactions;Human;human microbiota;Immune;Immune system;Immunologic Factors;immunoregulation;Incidence;Individual;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Iron;Knowledge;Lead;Leukocyte L1 Antigen Complex;Manganese;Mediating;member;Metal exposure;Metals;Microbe;microbial;microbial community;microbiome;microbiota;microbiota composition;Modeling;Molecular;Mus;Names;neutrophil;normal microbiota;Nutrient;Nutrient availability;nutrient deprivation;Nutritional;Nutritional Immunity;Outcome;pathogen;Pathogenesis;Pattern;Physiology;Play;Predisposition;prevent;Prevention strategy;Process;Production;programs;Property;Proteins;Public Health;recruit;Recurrent disease;Reproduction spores;Research;response;Role;Severities;Shapes;Site;Starvation;System;Testing;therapeutic development;therapeutically effective;Toxin;Trace metal;transcriptional reprogramming;treatment strategy;Up-Regulation;Vertebrates;young adult;Zinc

PROJECT_TITLE: Nutritional immunity and microbial competition during Clostridioides difficile infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-S(02)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: Project Narrative The highly pathogenic influenza viruses pose considerable public health threats with high morbidity and mortality. Infections can range from asymptomatic to deadly with varying host and viral factors associated with heterogenous outcomes. The objective of the proposed research is to develop and validate quantitative computational models and virtual patient cohorts that identify immunologic drivers of severity, biomarkers that define inflammation and distinct outcomes, and determine how distinct levels of basal immunity impact facilitate patient outcomes.

PI_NAMEs: CRAIG, MORGAN ;SMITH, AMBER M (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Address;Affect;African American;Age;Animals;Automobile Driving;Biological;Biological Factors;Biological Markers;Calibration;CD8B1 gene;Cells;Cessation of life;Clinical;clinical examination;cohort;comorbidity;Computer Models;Computing Methodologies;Correlation Studies;COVID-19;cytokine;Cytomegalovirus;Data;digital twin;Disease;Disease Management;Disease Outcome;Disease Progression;Dose;Economic Burden;Environmental Risk Factor;experimental study;Future;Genetic;Goals;Health;Heritability;Heterogeneity;Human;human data;Immune;Immune response;Immunity;Immunological Models;Immunologics;Immunology;immunopathology;improved;in silico;in vivo;Individual;Infection;Inflammation;Inflammatory;Influenza;influenza infection;Influenza vaccination;influenzavirus;Infrastructure;Integration Host Factors;Interleukin-6;Knowledge;Lung;Macrophage;Mathematics;Methods;Modeling;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Natural Immunity;neutrophil;Outcome;Parainfluenza Virus Infections;pathogen;Pathogenicity;Patient-Focused Outcomes;Pattern;Population;predictive marker;predictive modeling;Process;Public Health;Pulmonary Pathology;Research;Respiratory Tract Infections;respiratory virus;response;risk prediction;seasonal influenza;Seasons;Serology;Severities;Severity of illness;sex;Source;South American;success;T-Lymphocyte;time use;tool;Vaccination;Validation;Variant;Viral;virtual patient;Virus;Vitamin A Deficiency;Work

PROJECT_TITLE: Virtual Patient Cohorts to Illuminate Immunologic Drivers of Influenza Severity


NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Health Services;Hearing Loss;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention;Rehabilitation;Telehealth

ORG_DEPT: OTOLARYNGOLOGY

PHR: PROJECT NARRATIVE Understanding if a telehealth versus a clinic-based hearing care service delivery model can lead to improved hearing aid use and communicative function among older adults using hearing aids is important for guiding clinical care standards and policy decisions regarding hearing care coverage in the U.S. The goal of this proposal is to conduct a randomized trial of these two hearing care models in a follow-up study to the ongoing NIA-funded Aging and Cognitive Health Evaluation in Elders (ACHIEVE) study.

PI_NAMEs: LIN, FRANK R (contact);REED, NICHOLAS SALVATORE;SANCHEZ, VICTORIA ANN

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Adult;Age;Aging;Area;arm;Audiology;care delivery;care systems;Caring;Chronic;Clinic;Clinical;clinical care;Cognitive;cognitive function;cohort;Communication;Communication difficulty;Communities;Complement;Congresses;Control Locus;County;COVID-19 pandemic;Dementia;Education;efficacy trial;Elderly;Evaluation;follow-up;Follow-Up Studies;functional outcomes;Funding;Future;Goals;group intervention;Health;health care model;Health Educators;Healthcare;healthy aging;Hearing;Hearing Aids;hearing impairment;hearing loss treatment;Hour;Impaired cognition;improved;Individual;Intervention;Investments;Measures;Medicare;mental function;Mental Health;Modeling;modifiable risk;multi-site trial;older adult;Outcome;Outcome Measure;Participant;patient oriented;Patient-Focused Outcomes;Patients;Persons;Physical Function;Policies;post intervention;primary outcome;Provider;Psychological reinforcement;racial diversity;Randomized;randomized trial;recruit;Reporting;Research Personnel;Resources;Risk Factors;Role;Sampling;secondary outcome;Self Efficacy;Self Management;Service delivery model;Services;Site;Social Functioning;Specific qualifier value;stem;Technology;telehealth;Time;Transportation;uptake;Visit;Washington

PROJECT_TITLE: Randomized Trial of Telehealth vs Conventional Hearing Care Delivery in the ACHIEVE Study

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences

ORG_CITY: TUCSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: Project Narrative While there is widespread consensus that lesions to the human medial temporal lobes result in a profound loss of long-term verbal memory, there is now growing consensus in the field of cognitive neuroscience that the impairments following such lesions extend outside of this domain into perception, working memory, attention, language, and navigation. Yet how such deficits might arise cannot be accounted for by most contemporary models of medial temporal lobe function. Here, we propose to test a novel model that accounts for such representational impairments based on two dimensions: precision and binding. The expected outcomes of this grant are: 1) a more complete account of the patterns of cognitive deficits accompanying bilateral medial temporal lobe lesions, particularly those localized to the hippocampus (Aim 1), and, 2) more accurate modeling and prediction of the cognitive deficits accompanying unilateral temporal lobe resections to treat pharmacologically-intractable epilepsy (Aim 2).

PI_NAMEs: EKSTROM, ARNE D (contact);YONELINAS, ANDREW P

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Affect;aged;Amnesia;Area;Attention;Bilateral;Binding;Biological Assay;Brain;Breathing;Code;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive neuroscience;cognitive recovery;Compensation;Complex;Consensus;Data;Delayed Memory;Dimensions;Encephalitis;Excision;experience;experimental study;flexibility;Functional Magnetic Resonance Imaging;Grant;gray matter;Hippocampus;Human;Hypoxia;Impaired cognition;Impairment;improved;insight;Intervention;Intractable Epilepsy;Ischemia;Language;Lesion;long term memory;Measures;Medial;medial temporal lobe;Memory;Modeling;neocortical;Nervous System Disorder;network models;Network-based;neural;neuromechanism;Neuropsychological Tests;Neuropsychology;non-verbal;novel;novel marker;novel strategies;novel therapeutics;Operative Surgical Procedures;Outcome;Partial Epilepsies;Participant;Patients;Pattern;Perception;pharmacologic;Pharmacological Treatment;Play;Population;predictive modeling;predictive tools;Primary Lesion;Process;Recovery of Function;recruit;Resolution;Rest;Role;Short-Term Memory;spatial memory;Stroke;stroke patient;Symptoms;Temporal Lobe;Testing;theories;Tissues;two-dimensional;verbal;way finding

PROJECT_TITLE: Precision and binding as two dimensions of medial temporal lobe amnesia

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: Narrative Organisms adapt to detect and respond to their specific ecological or behavioral context. This research leverages several specialized sensory cell types across organisms to probe mechanisms underlying the detection, discrimination, and integration of environmental signals. Results from our studies will expand our understanding of signal transduction, single protein evolution and function, and aim to establish a foundation from which to develop therapeutics for various sensory processing disorders.

PI_NAMEs: BELLONO, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Affect;Animals;arm;Behavior;Behavioral;bioelectricity;Biological Models;Brain;cell type;Cells;Cellular biology;Detection;Discrimination;electric field;electrical property;Electrophysiology (science);Esthesia;Evolution;expression cloning;Fishes;flexibility;Foundations;Frequencies;genetic profiling;Hormones;in vivo;Individual;insight;Ion Channel;Methods;Molecular;multimodality;Natural Products Chemistry;Octopus;Organism;Output;Partner in relationship;Physiological;Property;protein structure function;Proteins;receptor;Research;response;Sensory;sensory processing disorder;Sensory Receptors;Sentinel;Shark;Signal Transduction;Specific qualifier value;Stimulus;System;Taste Perception;Therapeutic;Tissues;Touch sensation

PROJECT_TITLE: Molecular Mechanisms of Integrative Signal Transduction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Genetics

PHR: Project Narrative My lab discovered that the genetic code not only determines what information is within a gene but also how the message from that gene is read (how long it is read and how fast it is read). This becomes critical in understanding how all of these messages are coordinated by the cell to achieve higher order function. Cancer and viruses (such as H1N1 and SARS-coV-2) may also tap into these principles discovered by my lab, using the hidden information that is within the genetic code to take over cellular function.

PI_NAMEs: COLLER, JEFFERY  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 2019-nCoV;Accounting;Anticodon;Biological;Biology;Cell Physiology;Cells;Chemicals;Codon Nucleotides;Complex;Development;Disparate;DNA;Equilibrium;Eukaryota;Event;Gene Expression Regulation;Genes;Genetic Code;genetic information;Genetic Transcription;Influenza A Virus, H1N1 Subtype;Malignant Neoplasms;Messenger RNA;Modification;Molecular;Monitor;Movement;mRNA Stability;mRNA Transcript Degradation;Pathway interactions;Prevalence;Process;Proteins;Regulation;response;Ribosomes;Speed;Thermodynamics;Transcriptional Regulation;Transfer RNA;transmission process;Virus;Work;Yeasts

PROJECT_TITLE: Understanding the relationship between codon optimality and mRNA stability

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: NEW YORK

ORG_NAME: HUNTER COLLEGE

PHR: PROJECT NARRATIVE / RELEVANCE STATEMENT Hunter College of the City University of New York (CUNY) recognizes the importance of diversifying the U.S. biomedical workforce. The MARC Program at Hunter College will provide research training in the biomedical sciences to underrepresented undergraduate students, preparing them to successfully complete their PhD. Thus, this program will educate and train the next generation of diverse scientists to engage in research to benefit public health.

PI_NAMEs: FORD, JENNIFER S (contact);ORTIZ, BENJAMIN D.,

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: academic program;Academic support;Admission activity;Behavioral Research;Benchmarking;Biomedical Research;career;CCL7 gene;Collaborations;college;Communication;Development;Development Plans;Doctor of Philosophy;Environment;Goals;graduate student;Institution;interest;Intervention;Laboratory Research;Learning;matriculation;Monitor;multidisciplinary;Program Evaluation;programs;Research;Research Personnel;resilience;Route;Science;Scientist;Self Efficacy;skills;socioeconomic disadvantage;STEM research;student participation;student training;Students;Training;training opportunity;undergraduate student;Underrepresented Populations;Underrepresented Students;university student;Work

PROJECT_TITLE: MARC Program at Hunter College, CUNY

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ORG_CITY: Columbus

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative The small, ubiquitous and universal Ca-binding protein, calmodulin, either directly controls, or at minimum, modulates every functionality within the heart. This versatile protein is the only known exception to the central rule of biology - one gene one protein, since in all mammalian cells, an identical CaM protein is derived from three different genes, Calm1, 2 and 3. We are discovering that there are robust regulatory mechanisms within calmodulin's three unique mRNAs that dictate where and with which protein target they are translated locally within the cardiac myocyte.

PI_NAMEs: DAVIS, JONATHAN PAUL;GYORKE, SANDOR  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: 3' Untranslated Regions;Ablation;Adult;Binding;Binding Proteins;Biological;Biology;Calmodulin;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;cell type;Cells;Complex;Computer software;Coupling;crosslink;Data;Data Analyses;Development;Disease;disease phenotype;Genes;Genetic Transcription;Golgi Apparatus;Health;Heart;Heart Diseases;Human;Hypertrophy;Imaging Device;Imaging Techniques;Individual;Integral Membrane Protein;Intercalated disc;Ion Channel;Knowledge;Mammalian Cell;Mediating;Membrane Proteins;Messenger RNA;Molecular;Mus;Muscle Cells;novel;Nuclear;Pathologic;Pathology;Physiological;Physiology;Process;Production;Protein Engineering;protein function;Proteins;recruit;Regulation;response;Ribosomes;RNA;RNA-Binding Proteins;Role;Rough endoplasmic reticulum;RyR2;Scientist;Signal Transduction;Site;Specificity;Talents;Testing;Therapeutic;Time;trafficking;Translating;translational approach;Translations;Ventricular;Visualization

PROJECT_TITLE: Regulation and Dysregulation of Cardiac EC coupling by Calmodulin

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Human acute myeloid leukemia (AML) is an aggressive blood cancer with a high mortality rate and dismal overall survival. A majority of AML patients die from complications arising from bone marrow failure which causes decreased production of blood forming cells. However, we lack fundamental knowledge regarding the mechanism driving this phenomenon. I aim to characterize the mechanisms underlying AML-induced bone marrow failure to identify novel avenues for therapeutic interventions.

PI_NAMEs: ZHANG, TIAN YI  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: 27-hydroxycholesterol;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adherence;Adult;Apoptosis;ATP-Binding Cassette Transporters;Automobile Driving;Award;Biological Assay;Blood;Blood Vessels;Bone Marrow;Bone marrow failure;Bone Marrow Purging;burden of illness;Cell Cycle;Cell Line;Cell Physiology;Cells;Cessation of life;Cholesterol;Cholesterol Homeostasis;Circulation;Coculture Techniques;Confocal Microscopy;Cytochrome P450;cytopenia;Data;Death Rate;Derivation procedure;Discipline;Disease;early phase clinical trial;Elements;Endothelium;Environment;Enzyme-Linked Immunosorbent Assay;Enzymes;Extramedullary Hematopoiesis;Failure;FDA approved;Flow Cytometry;Frequencies;Funding;Genetic;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic Stem Cell Mobilization;Hematopoietic stem cells;Human;human disease;human stem cells;Hydroxycholesterols;Immunofluorescence Immunologic;In Vitro;in vivo;insight;Institution;Knowledge;Knowledge acquisition;Laboratories;Learning;Lipoprotein Receptor;Liver;Luciferases;Malignant - descriptor;Malignant Neoplasms;Marrow;medical schools;Mentors;Mentorship;mesenchymal stromal cell;Metabolic Pathway;monocyte;mortality;Mus;Nature;novel;Operative Surgical Procedures;paracrine;Pathology;Pathway interactions;Patients;Peripheral;peripheral blood;Pharmaceutical Preparations;Population;pre-clinical;Pregnancy;Process;Production;progenitor;Proliferating;protein expression;Reporter;Research;Reverse Transcriptase Polymerase Chain Reaction;Role;single-cell RNA sequencing;skills;Source;Spleen;Splenectomy;stem;stem cells;Stress;Stromal Cell-Derived Factor 1;survival outcome;Taxonomy;Techniques;Testing;Therapeutic Intervention;therapeutic target;Training;Transcript;transcriptome;transcriptome sequencing;Translating;Universities;Western Blotting;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Dissecting the Mechanism of Acute Myeloid Leukemia Induced Bone Marrow Failure to Identify Therapeutic Interventions

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: SAN DIEGO

ORG_DEPT: CHEMISTRY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Diverse teams of scientists are more likely to address issues of higher impact and complexity and produce more innovative and creative solutions. To ensure the robust health of the biomedical research enterprise, the SDSU MARC program seeks to identify and nurture the talent and potential of historically excluded students in science, technology, engineering, and mathematics (STEM). MARC scholars benefit from research-validated, supportive, and culturally aware programming and cutting-edge research experiences that prepare them for success in graduate programs and as future leaders in the biomedical workforce.

PI_NAMEs: SOHL, CHRISTAL DYANE (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Ally;Awareness;Breathing;career;combat;Communication;Country;Creativeness;Critical Thinking;Data;Dedications;Development;disability;disadvantaged background;Doctor of Philosophy;Educational workshop;empowerment;Ensure;Equity;Ethics;Evaluation;evidence base;Exclusion;experience;faculty mentor;Health;Home;improved;Infrastructure;innovation;Instruction;interest;K-Series Research Career Programs;Lead;Leadership;lens;Mental Health;Mentors;Mentorship;Methods;Minority Groups;Oral;peer coaching;Personal Satisfaction;Persons;Population;programs;recruit;Reproducibility;Research;resilience;Scientist;Self Efficacy;Services;skills;social;STEM field;STEM student;Students;success;synergism;Technical Expertise;Training;Underrepresented Minority;Underrepresented Populations;United States;Universities;Well in self;Writing

PROJECT_TITLE: MARC at San Diego State University


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative PD/PI: Laura B. Duvall PhD Mosquitoes spread pathogens by biting humans to feed on their blood and using the protein from these meals to develop eggs and reproduce. This research project will characterize neuropeptide signaling pathways and anatomy that underlie the physiological changes that control blood-feeding and mating behaviors. These results will inform new strategies to prevent the spread of illnesses including Zika, dengue fever, and chikungunya by directly targeting the pathways that make these mosquitoes effective vectors for disease.

PI_NAMEs: DUVALL, LAURA  (contact)

PROJECT_TERMS: Affect;Anatomy;Animals;Behavior;Behavioral;Biology;Bite;Blood;Cells;chikungunya;Culicidae;Dengue Fever;detection of nutrient;Development;Disease;Disease Vectors;Doctor of Philosophy;drug action;egg;Ensure;Environmental Risk Factor;Fathers;feeding;Feeding behaviors;Female;Genetic Techniques;Human;Human Bites;Individual;innovation;Instinct;Label;Ligands;Liquid substance;Malaria;male;Maps;mating behavior;Mediating;Mosquito Control;motivated behavior;Neuropeptides;Nutritional;offspring;Partner in relationship;pathogen;Pathway interactions;Peptide Signal Sequences;Peptides;Perception;pharmacologic;Phase;Physiological;Physiology;Play;prevent;Proteins;Public Health;receptor;Regulation;Reproduction;Research Project Grants;Resources;response;Satiation;screening;Sensory;Signal Pathway;Signal Transduction;small molecule;Techniques;transmission process;vector;vector control;weapons;Work;ZIKA

PROJECT_TITLE: Peptide regulation of blood-feeding and mating physiology in mosquitoes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: EB

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: SEATTLE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Relevance to public health: The development of a focused ultrasound treatment for abscesses will improve patients’ lives because it is minimally or noninvasive, has less procedural pain, can be performed in an out-patient setting, and is fast and convenient. Physicians benefit because it minimizes risk of non-targeted injury and complications, and there is minimal additional training to use the device.

PI_NAMEs: MATULA, THOMAS  (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: Abscess;Acoustics;Acute;Acute-Phase Proteins;Affect;Aftercare;Animals;Antibiotic Resistance;Antibiotics;arm;aspirate;Bacteria;Blood;Body part;capsule;Caring;Catheter Management;Catheters;Chronic;Circulation;Clinical Trials;clinically relevant;Connective Tissue;contrast enhanced;Data;Development;Devices;Disease;Dose;Drainage procedure;Drug resistance;drug resistance development;Evaluation;Extravasation;Family suidae;Fine needle aspiration biopsy;first-in-human;Focused Ultrasound;Focused Ultrasound Therapy;global health;Goals;healing;Healthcare;Hematoma;Histologic;Hospital Charges;hospital readmission;Hospitalization;Human;Image;image guided;improved;In Vitro;in vivo;Infection;Injury;innovation;Length of Stay;Life;Lipopolysaccharides;Liquid substance;Measures;Mechanics;Methods;Microbe;Modality;Modeling;Monitor;Morbidity - disease rate;Needles;Operative Surgical Procedures;Oryctolagus cuniculus;Outcome;Outpatients;Patients;Pattern;Physicians;Physiologic pulse;Positioning Attribute;pre-clinical;Predisposition;procedural pain;Protocols documentation;Public Health;Pus;pus collection;Radiation;Rattus;response;risk minimization;Safety;Specific qualifier value;standard of care;Stream;success;Surgical complication;Time;Training;Trauma;Treatment Efficacy;Treatment Protocols;Ultrasonic Therapy;ultrasound;Viscosity

PROJECT_TITLE: Image-Guided Focused Ultrasound Treatment of Abscesses