NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Telehealth;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE After a sexual assault, peers often express confusion about how to best support survivors and may encourage drinking to cope, which can exacerbate the wide range of physical and mental health problems survivors experience, contributing to persistent distress, long-term healthcare costs, and loss of productivity. The current project involves the design and feasibility testing of a novel web-based intervention to increase effective peer support of survivors by focusing on behaviors incompatible with heavy drinking, which will in turn reduce alcohol use and related consequences within high-risk social networks of sororities. If feasibility and preliminary intervention effects are supported, this intervention could be widely disseminated and facilitate change in drinking norms among social networks of young adults, as well as mitigate distress after sexual assaults.

PI_NAMEs: JAFFE, ANNA E. (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Affect;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol misuse prevention;alcohol research;Alcohols;Altruism;assault;Awareness;Baseline Surveys;Behavior;Behavioral;brief intervention;career;Characteristics;Clinical;Cluster randomized trial;college;college drinking;Communication;Communities;community collaboration;Confusion;coping;Data;design;Development;Distress;Documentation;drinking;Educational Intervention;efficacy testing;Emotional;Environment;Evaluation;experience;feasibility testing;follow-up;Foundations;Friends;Goals;Health Care Costs;Heavy Drinking;high risk;high risk population;improved;indicated prevention;Individual;innovation;Intervention;intervention effect;Intervention Studies;K-Series Research Career Programs;Light;Maintenance;member;Mental Health;Mentors;Mentorship;Methodology;Mission;Modeling;National Institute on Alcohol Abuse and Alcoholism;normative feedback;novel;online delivery;Online Systems;Participant;peer;peer networks;peer support;physical conditioning;Play;post-traumatic stress;Preparation;productivity loss;prototype;psychoeducation;Public Health;Randomized;Reaction;Recovery;reduced alcohol use;Relaxation;Reporting;Research;Research Personnel;Research Support;Research Training;Resources;Role;Scientist;services as usual;sexual assault;Site;skills training;social movement;Social Network;Statistical Data Interpretation;Students;substance use;Surveys;Survivors;Technology;technology intervention;Testing;therapy design;therapy development;Time;Training;Trauma;Trauma recovery;Uncertainty;Universities;Washington;web-based intervention;Woman;young adult

PROJECT_TITLE: Leveraging Social Networks to Promote Sexual Assault Recovery and Reduce Drinking to Cope through a Web-Based Intervention

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Narrative The mechanisms that underlie the neurodegeneration, abnormal brain activity, and motor symptoms in Parkinson's disease (PD) remain poorly understood. To help fill this gap, a range of cutting-edge approaches will be used in a novel mouse model of PD. These studies have clear translational potential for PD patients.

PI_NAMEs: BEVAN, MARK D;SURMEIER, DALTON JAMES (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Achievement;Adenosine Triphosphate;Anatomy;Animal Model;Aromatic-L-Amino-Acid Decarboxylases;Attenuated;Automobile Driving;Axon;Basal Ganglia;Behavioral;Bioenergetics;Biological Markers;Bradykinesia;brain abnormalities;Catalytic Domain;Cell Nucleus;cellular pathology;Characteristics;Clinical;Complex;Corpus striatum structure;dopaminergic neuron;Dorsal;Down-Regulation;Electron Transport;Electrophysiology (science);Elements;Event;Exhibits;falls;Foundations;Functional disorder;functional loss;functional restoration;Genetic;Glycolysis;Human;immunoreactivity;insight;Knock-out;Learning;Levodopa;Mitochondria;Modeling;Motor;motor deficit;motor impairment;motor symptom;mouse model;Mus;Nerve Degeneration;network dysfunction;neural network;Neurons;novel;novel therapeutic intervention;Optics;optogenetics;Output;Parkinson Disease;Parkinsonian Disorders;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Phenotype;Play;prevent;Property;Role;Signal Transduction;Staging;Substantia nigra structure;success;symptom treatment;Symptomatic Parkinsonism;Symptoms;Synapses;Testing;Time;tool;transcriptomics;translational potential;Tyrosine 3-Monooxygenase;Viral;viral gene delivery

PROJECT_TITLE: Determinants of Basal Ganglia Pathology in Parkinson's Disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative If our goal is to obtain an unbiased estimate of treatment effect, randomized clinical trials must be conducted. By allowing UTH to continue in the MFMU Network, we will substantially contribute to improving the mother-child dyad by effectively conducting such trials. Our history within the Network is a testament to our commitment to fulfilling the goals of the NICHD’s Strategic Plan 2020.

PI_NAMEs: MENDEZ-FIGUEROA, HECTOR  (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: adverse outcome;Birth;Birth Rate;career development;Cementation;Cesarean section;Child;Cities;Clinical;Clinical Research;Country;COVID-19 pandemic;Data;data quality;double-blind placebo controlled trial;Eligibility Determination;Enrollment;Ensure;experience;Faculty;Fellowship;follow-up;Funding;Future;Goals;Health Services;Hospitals;improved;Infrastructure;interest;Knowledge;Lactation;Longitudinal Studies;Longterm Follow-up;Maternal-Fetal Medicine Units Network;member;Minority Groups;Minority Women;Mission;Mothers;Multicenter Trials;National Institute of Child Health and Human Development;Nature;obstetric care;Outcome;Participant;participant enrollment;patient population;Patients;Peer Review;Performance;Persons;Population Heterogeneity;Positioning Attribute;Pregnancy;pregnancy health;pregnant;Premature Birth;Productivity;prospective;Protocols documentation;Publishing;racial diversity;Randomized;randomized, clinical trials;Recommendation;Recording of previous events;recruit;Research;Research Personnel;secondary analysis;Services;Site;skills;Societies;Strategic Planning;study population;success;Texas;tool;treatment effect;Underrepresented Minority;United States National Institutes of Health;Universities

PROJECT_TITLE: Eunice Kennedy Shriver NICHD Maternal-Fetal Medicine Units (MFMU) Network (UG1)


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE The proposed research will develop and evaluate an implementation strategy that targets the balance between intervention fidelity and flexibility (i.e., co-production) in order to enhance caregiver engagement within a parent-mediated intervention (PMI) for Autism Spectrum Disorder (ASD) when delivered in a state-funded Early Intervention system. This is a critical need given high attrition when PMIs have been delivered in diverse community settings, which may reflect an emphasis on implementing and adapting PMIs in a manner that maintains fidelity while also conflicting with the complex needs of underrepresented families. This proposal and my long-term goals are aligned with NIMH’s objective [4.3a to adapt evidence-based models to account for moderators, including social determinants of health, that impact intervention effectiveness among underrepresented groups], as this project will develop and provide evidence on the feasibility of an implementation strategy aimed at enhancing caregiver engagement by blancing fidelity to an evidence-based PMI with the needs and priorities of caregivers who have been historically underrepresented in ASD early intervention research.

PI_NAMEs: PICKARD, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: access disparities;Address;Area;autism spectrum disorder;autistic children;career;Caregivers;Caring;Cessation of life;Child;Child Development;Clinical;clinical decision-making;Clinical Trials;Clinical Trials Design;Communities;community engaged research;community setting;Complex;Cultural Diversity;Data;design;Doctor of Philosophy;Drops;Early Intervention;Educational process of instructing;Effectiveness;Effectiveness of Interventions;Enrollment;Equilibrium;Evaluation;Event;evidence base;Evidence based intervention;Evidence based treatment;experience;Family;flexibility;Funding;Goals;Housing;Hybrids;implementation evaluation;implementation strategy;improved;Inequity;Intervention;intervention delivery;Intervention Studies;K-Series Research Career Programs;Knowledge acquisition;marginalized community;Mediating;Mediator;Mentors;Mentorship;Methods;Modeling;National Institute of Mental Health;Nobel Prize;Outcome;Parents;Patient-Focused Outcomes;Positioning Attribute;Postdoctoral Fellow;Process;Production;Provider;Quality of life;randomized trial;Reporting;Research;Research Personnel;response;Role;Scientist;service delivery;Service delivery model;Services;Shapes;shared decision making;skills;social health determinants;success;System;Testing;Training;Training Support;Translating;Translations;Underrepresented Populations;Work

PROJECT_TITLE: Examining co-production as an implemntation strategy for autism early intervention delivered in Part C service systems

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: Chicago

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Narrative: To make new breakthroughs in the treatment of cancer, the underlying mechanisms of cellular dysfunction must be better understood. In this project we will use a state-of-the- art, CRISPR-based technology platform to rapidly identify and validate new molecular targets for drug discovery. This technology will provide essential molecular information for development of cancer therapeutics, particularly immunotherapies.

PI_NAMEs: ANGERS, STEPHANE ;KELLEY, SHANA O (contact);MOFFAT, JASON

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: 3D Print;Acceleration;Antibodies;Benchmarking;Biological;Biological Assay;Cancer Biology;cancer immunotherapy;cancer therapy;cancer type;CD47 gene;CD47-SIRPα;cell fixation;Cell Line;Cell Separation;Cell surface;Cell Surface Proteins;Cell Survival;cell type;Cells;checkpoint therapy;Communities;cost;CRISPR screen;CRISPR/Cas technology;Data;data integration;Data Set;Databases;Development;Device or Instrument Development;Devices;Disease;drug discovery;Drug Targeting;Eating;Enzymes;Exhibits;Fluorescence-Activated Cell Sorting;Functional disorder;functional genomics;Genes;Genetic;Genetic Screening;genome editing;genome wide screen;genome-wide;Genotype;Hour;Human Biology;human disease;Human Genome;immune checkpoint;Immune checkpoint inhibitor;Immunoglobulin Domain;Immunotherapy;instrumentation;knock-down;Label;Macrophage;Magnetism;Malignant Neoplasms;Microfluidic Microchips;microfluidic technology;Microfluidics;Modification;Molecular;molecular drug target;Monitor;multidisciplinary;Mutation;Myeloid Cells;new technology;new therapeutic target;next generation;novel;novel therapeutics;Pathway interactions;Performance;Phagocytosis;Pharmacotherapy;Phenotype;Post-Translational Protein Processing;Process;Proliferating;protein expression;Proteins;PTPNS1 gene;Recovery;Regulatory Element;Research Personnel;Resolution;Role;scale up;screening;Series;Signal Pathway;Signal Transduction;Small Interfering RNA;Sorting;Specificity;Stimulator of Interferon Genes;Stress;Suppressor-Effector T-Lymphocytes;Surveys;System;T-Cell Activation;Technology;technology platform;Testing;Therapeutic;therapeutic development;timeline;tool;tumor;Validation;validation studies;whole genome

PROJECT_TITLE: Development of microfluidic enabled CRISPR-Cas9 functional genetic screening technologies for target discovery in cancer immunotherapy

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Through renewal and active participation in this multicenter collaborative research program, UAB clinical center researchers will assist the MFMU Network in conceiving and designing new innovative studies and complete ongoing projects intended to improve obstetric care, pregnancy health, and outcomes for pregnant and lactating people and their babies. These problems include maternal mortality and morbidities related to pregnancy, labor, and post-partum recovery; preterm birth and infant mortality. Our diverse team will continue to support activities of the MFMU to address health disparities through inclusion of our racially and ethnically diverse population.

PI_NAMEs: TITA, ALAN THEVENET N. (contact)

PROJECT_TERMS: Address;Alabama;American Heart Association;Chairperson;Chronic;Clinical;clinical center;Clinical Trials;Collaborations;Data;data centers;Data Management Resources;design;Disparity;Doctor of Philosophy;Electronic Health Record;Eligibility Determination;Enrollment;Environment;ethnic diversity;experience;Follow-Up Studies;Goals;health disparity;Health equity research;Health system;high risk;Home;Human Resources;Hypertension;improved;Individual;Infant Health;Infant Mortality;infant outcome;Infrastructure;innovation;International;Lactation;Leadership;Maternal Health;maternal morbidity;Maternal Mortality;maternal outcome;Maternal-fetal medicine;Maternal-Fetal Medicine Units Network;meetings;member;National Institute of Child Health and Human Development;next generation;Observational Study;obstetric care;Outcome;Participant;Patients;Peer Review;Performance;Persons;Play;Population;Population Heterogeneity;Positioning Attribute;Postpartum Period;Pregnancy;pregnancy health;pregnant;Premature Birth;Prenatal care;programs;Protocols documentation;Publications;racial diversity;Recording of previous events;Recovery;recruit;Reproducibility;Research;Research Personnel;Research Support;Resources;Role;Site;success;System;Training;U-Series Cooperative Agreements;Universities;women's reproductive health

PROJECT_TITLE: Maternal-Fetal Medicine Units (MFMU) Network


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The NICHD MFMU Network is the premier obstetric research network in the world. Clinical investigations of the causes of maternal, perinatal, and infant mortality and morbidity and their ultimate prevention require large and diverse numbers of participants who are recruited from multiple collaborating centers. The Ohio State University Center has been a leading member of the MFMU Network since 1992 and has an energized research team committed to building upon our tradition of excellence in order to achieve the goals of the Network in conducting clinical trials and observational studies in a collaborative approach across all Network centers.

PI_NAMEs: COSTANTINE, MAGED  (contact)

PROJECT_TERMS: acute care;Adherence;American;Anesthesiology;antenatal;Authorization documentation;Beds;Bioinformatics;Birth;Caring;Cesarean section;Child;Childhood;Clinic;Clinical;Clinical and Translational Science Awards;clinical center;clinical infrastructure;clinical investigation;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;collaborative approach;collaborative environment;Collection;Conduct Clinical Trials;Data;data access;Data Analyses;Data Collection;Data Coordinating Center;data quality;data sharing;Dedications;Department chair;Discipline of obstetrics;Disparity;disparity reduction;electronic medical record system;Eligibility Determination;Ensure;Environment;Epidemiologist;Epidemiology;Equity;ethnic disparity;ethnic diversity;experience;Faculty;fetal;follow-up;Foundations;Goals;Grant;Health system;Helping to End Addiction Long-term;Hepatitis C;high risk;high risk population;Hospitals;Human Resources;improved;Induced Labor;infant morbidity/mortality;Information Dissemination;Infrastructure;innovation;Inpatients;Institution;intrapartum;Knowledge;Laboratories;Lactation;Link;Longterm Follow-up;Manuscripts;maternal morbidity;Maternal Mortality;Maternal-fetal medicine;Maternal-Fetal Medicine Units Network;Medical center;member;Multi-Institutional Clinical Trial;Multi-site clinical study;Multicenter Neonatal Research Network;National Institute of Child Health and Human Development;Neonatal;Neonatology;Network-based;Notification;novel;Nurses;Observational Study;obstetric care;obstetric outcomes;Obstetric pharmacology;Ohio;opioid use disorder;organizational structure;Outcome;Outpatients;Participant;Pathology;patient oriented;Patient Recruitments;patient retention;Patients;Pediatric Hospitals;Performance;Perinatal;perinatal health;perinatal morbidity;Perinatal mortality demographics;Persons;Pharmacology;Population Heterogeneity;Positioning Attribute;Postpartum Period;Pre-Eclampsia;pregnancy health;Pregnancy in Diabetics;pregnant;Premature Birth;Prenatal care;prevent;Prevention;Procedures;Process;Productivity;programs;protocol development;Protocols documentation;Provider;Publishing;racial disparity;racial diversity;recruit;Reproducibility;Research;Research Design;Research Infrastructure;Research Personnel;Research Subjects;Researching COVID to Enhance Recovery;Resources;response;retention rate;Services;Site;Structure;study population;Study Subject;System;Therapeutic;Translational Research;Trial of Labor;United States National Institutes of Health;Universities

PROJECT_TITLE: NICHD maternal fetal medicine units network


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Drugs that activate opioid receptors are widely used as analgesics, but they can cause serious problems such as opioid use disorder and respiratory depression. The vast majority of studies on opioid receptors have used exogenous ligands, and only a few studies have investigated the biological peptides that normally activate the receptors in the body. We will study the signaling induced by endogenous opioid peptides versus representative opioid drugs, in order to identify potential target mechanisms for developing better analgesics with fewer unwanted side-effects.

PI_NAMEs: DEVI, LAKSHMI A (contact);MARGOLIS, ELYSSA ;PUTHENVEEDU, MANOJKUMAR A

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Acute;addiction;addiction liability;Address;Affinity;Agonist;Analgesics;antinociception;beta-arrestin;Binding;Biological;Biological Assay;Brain;Brain region;brain tissue;Cell Line;Cell Nucleus;Cell surface;Cells;Cessation of life;clinically relevant;Collaborations;Dangerousness;Data;Data Analyses;data mining;delta opioid receptor;desensitization;design;Disease;drug development;Dynorphins;Electrophysiology (science);endogenous opioids;Endorphins;Endosomes;Enkephalins;Event;Exhibits;experimental study;Fentanyl;Fluorescence Microscopy;Foundations;Glutaminase;GTP-Binding Proteins;In Situ;In Vitro;in vivo;Individual;Knowledge;large datasets;Ligands;Location;Mediating;Mediator;Medicine;Mental Depression;Mitogen-Activated Protein Kinases;Modeling;Modernization;Monitor;Morphine;mu opioid receptors;nanobodies;nanomolar;Neurons;novel therapeutics;Opioid;opioid epidemic;Opioid Peptide;Opioid Receptor;opioid use disorder;Organelles;Pain management;Pathway interactions;Pattern;Peptide Receptor;Peptides;Pharmaceutical Preparations;Phosphotransferases;Physiological;Physiological Processes;Play;Pro-Opiomelanocortin;prodynorphin;proenkephalin;Property;protein kinase C kinase;receptor;Receptor Activation;receptor function;Receptor Signaling;Recycling;Regulation;Reporting;Respiration;response;Rewards;Role;Scientist;secondary analysis;side effect;Signal Induction;Signal Pathway;Signal Transduction;Signaling Protein;Slice;Substance Use Disorder;synthetic drug;synthetic opioid;System;Talents;Techniques;Testing;therapeutic development;therapeutic target;Time;Toxic effect;trafficking;Translating;Ventilatory Depression;Ventral Tegmental Area;Vision;Work

PROJECT_TITLE: Regulation Of Opioid Receptor Signaling by Endogenous Peptides


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: STANFORD

ORG_DEPT: DERMATOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative  The tumor epithelium and stroma each contribute to tumor evolution and resistance, and tumor epithelial basal cell-to-squamous cell carcinoma transition, and a self-propagating, transplantable, and long-lived skin cancer-associated macrophage appear to be novel contributors to tumor resistance. Project completion will fill major gaps in how these two processes contribute to resistance, and lead to the nomination of novel cancer therapies.

PI_NAMEs: ORO, ANTHONY E (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Allografting;Basal Cell;Basal cell carcinoma;Basal Cell Neoplasm;biomarker identification;cancer therapy;Carcinoma;cell growth;cell type;Cells;Cellular Morphology;Chromatin;Clinical;cofactor;combinatorial;Combined Modality Therapy;Dependence;Dimensions;Disease;drug sensitivity;efficacy evaluation;Environment;Epigenetic Process;Epithelium;Erinaceidae;Evolution;FOS gene;Funding;Genetic;Genetic Transcription;Genomics;Growth;Heterogeneity;immune checkpoint;improved;inhibitor;insight;keratinocyte;Knowledge;Macrophage;MAP Kinase Gene;Maps;Mediating;Modeling;Morbidity - disease rate;mortality;Mus;neoplastic cell;new therapeutic target;novel;novel therapeutics;Oral;Organoids;Outcome;Pathway interactions;Patients;Population;Process;Regulation;Resistance;resistance mechanism;Signal Pathway;Signal Transduction;single cell analysis;Skin;Skin Cancer;Skin Carcinoma;smoothened signaling pathway;Squamous Cell;Squamous cell carcinoma;Surface;Testing;Therapeutic Intervention;therapy development;therapy resistant;transcription factor;Transcription Factor AP-1;Transplantation;TREM2 gene;tumor;tumor heterogeneity;Tumor-associated macrophages;Withdrawal

PROJECT_TITLE: Stromal Regulation of Basal Cell Carcinoma Formation

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Oncogenic long noncoding RNAs (LncRNAs) contribute to many mechanisms of cancer biology. This project investigates how a single chemical modification to a breast-cancer associated LncRNA can potentiate its oncogenic activity, whereas disruption of this modification can switch the LncRNA to an anti-tumor mechanism. Proof-of-principle experiments to manipulate this switch for novel therapeutic intervention will guide a long-term goal of clinical application.

PI_NAMEs: JOHNSON, AARON M. (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Address;Affect;anti-cancer;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Atmosphere;Behavior;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;breast cancer progression;Cancer Biology;cancer cell;cancer therapy;cancer type;carcinogenesis;Cell Line;Cells;Chemicals;Clinic;clinical application;Code;Diagnosis;experimental study;Future;Gene Expression;gene repression;Gene Targeting;Genes;Genetic Transcription;Goals;Growth;inhibitor;Intervention;Lead;Length;Malignant Breast Neoplasm;Malignant Neoplasms;MDA MB 231;Methylation;Modification;Molecular;mutant;Mutate;novel strategies;novel therapeutic intervention;novel therapeutics;Nuclear;Nucleotides;Oncogenes;Oncogenic;overexpression;Pathway interactions;Patient-derived xenograft models of breast cancer;Patients;Pattern;Phenotype;Prevention;Process;Property;Proteins;Proteomics;RNA;RNA delivery;RNA methylation;RNA vaccine;Role;Site;Suppressor Mutations;Testing;Therapeutic;Therapeutic Intervention;therapeutic RNA;Transcript;tumor;Tumor Suppressor Proteins;Untranslated RNA;vaccine delivery;Work;Xenograft procedure

PROJECT_TITLE: Disrupting long noncoding RNA methylation to elicit antimorph behavior in breast cancer


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Precision Medicine

ORG_CITY: MADISON

ORG_NAME: MORGRIDGE INSTITUTE FOR RESEARCH, INC.

ORG_STATE: WI

PHR: PROJECT NARRATIVE Improved treatment strategies for patients with cancer require enhanced tools to better predict patient response, model clonal heterogeneity, and identify novel treatment options for individual patients. This study validates accessible optical imaging tools and heterogeneity analysis to assess patient-derived tumor organoids for this purpose. These insights could ultimately lead to improved treatment options for cancer patients.

PI_NAMEs: DEMING, DUSTIN A;SKALA, MELISSA CAROLINE (contact)

PROGRAM_OFFICER_NAME: SORG, BRIAN S

PROJECT_TERMS: 3-Dimensional;Architecture;Cancer Patient;cancer type;Cell Communication;Cell Line;Cells;chemotherapy;Clinic;Clinical;clinical predictors;Clonal Evolution;Coenzymes;colon cancer patients;Colorectal Cancer;colorectal cancer treatment;Complex;cost;Culture Techniques;Development;disease model;drug candidate;drug development;Drug resistance;Drug Screening;Dyes;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Evolution;experience;Fluorescence;Genetic;Genetic Heterogeneity;Goals;Heterogeneity;high throughput screening;Hour;Human;human model;Image;Image Analysis;Imaging Device;Imaging Techniques;improved;in vivo;individual patient;insight;Label;Laboratories;Maintenance;Malignant Neoplasms;Measures;Metabolic;metabolic imaging;metastatic colorectal;Methods;Microscopy;Modeling;Molecular;Monitor;Multivariate Analysis;non-invasive imaging;novel;novel drug combination;novel therapeutics;optical imaging;Optics;Organoids;Patient imaging;patient response;Patients;Pharmaceutical Preparations;Photons;predicting response;Prediction of Response to Therapy;prevent;Reader;Reagent;Receptor Inhibition;Resistance;response;sample fixation;Sampling;screening;targeted treatment;Techniques;Technology;Testing;Time;tool;Translational Research;translational study;treatment planning;treatment response;treatment strategy;tumor;tumor DNA;two-photon;validation studies;Work

PROJECT_TITLE: Functional optical imaging for rapid, label-free predictions of treatment response and clonal evolution in patient-derived cancer organoids

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative P-glycoprotein is an energy-dependent efflux pump that plays a critical role in drug resistance, drug-drug interactions and drug-nutrient interactions. Understanding of the conformational dynamics of P-gp is necessary to improve prediction of the role of P-gp in these interactions.

PI_NAMEs: ATKINS, WILLIAM M (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: ABCB1 gene;ATP Hydrolysis;ATP phosphohydrolase;ATP-Binding Cassette Transporters;Behavior;Binding;Binding Sites;cancer cell;Cell membrane;Cells;Charge;Cholesterol;Coupled;Coupling;detoxication;Deuterium;Disease;Drug Interactions;Drug resistance;efflux pump;Elements;Environment;Equilibrium;Exhibits;Expenditure;flexibility;Fluorescence;Fluorescence Spectroscopy;Food-Drug Interactions;Goals;Health;Heterogeneity;Human;Hydrogen;improved;inhibitor;kinetic model;Kinetics;Knowledge;Ligand Binding;Ligands;Lipid Bilayers;Lipids;Literature;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Membrane;Membrane Fluidity;Membrane Lipids;Methods;Micelles;Molecular;Molecular Biology;Molecular Conformation;nanodisk;Nucleotides;Nutrient;overexpression;Pharmaceutical Preparations;Play;preference;Proteins;Pump;Reaction;recruit;residence;response;Role;Series;single molecule;small molecule;Sphingomyelins;stopped-flow fluorescence;Structure;Suggestion;Surface;Theoretical model;Tissues;Tryptophan;Vesicle;Xenobiotics

PROJECT_TITLE: Drug, Nucleotide, and Lipid Interactions with P-glycoprotein

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Ataxia Telangiectasia;Cancer;Genetics;Neurodegenerative;Neurosciences;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE. Ataxia telangiectasia (A-T) is a genetic disorder characterized by cerebellar neurodegeneration, progressive pulmonary dysfunction, immunodeficiencies, insulin resistance, sterility, and cancer predisposition. Data from the Kastan lab suggests that ATM, the gene which is mutated in A-T, plays an essential role in regulating metabolic function, mitochondrial quality control, and redox homeostasis through interactions with the autophagy regulator Beclin-1 and novel, as of yet uncharacterized cytoplasmic proteins. The experiments outlined in this proposal will explore validate these interactions and explore their functional impacts on mitochondrial, metabolic, and redox homeostasis.

PI_NAMEs: BURRELL, PAIGE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Affect;Aging;Alleles;Antibodies;Ataxia;Ataxia Telangiectasia;ataxia telangiectasia mutated protein;ATM activation;ATM deficient;ATM function;ATM gene;ATM null mice;ATM Signaling Pathway;Autophagocytosis;Autophagosome;BCL2 gene;Binding;Biological Assay;Calcium Signaling;cancer predisposition;cell immortalization;Cell Physiology;Cell Respiration;Cells;Clinical;Complex;Consensus;CRISPR/Cas technology;Cytoplasm;Cytoplasmic Protein;Data;Data Set;Development;DNA Damage;Down-Regulation;Electron Transport;Embryo;Endoplasmic Reticulum;Energy Metabolism;Ensure;experimental study;Exposure to;Family;Fibroblasts;Flow Cytometry;Functional disorder;Genes;Genetic Diseases;Genus Hippocampus;GRP94;Heat-Shock Proteins 90;Heterozygote;Homeostasis;Human;immunodeficiency;Immunoprecipitation;Impairment;In Vitro;Insulin Resistance;interest;Lead;Leucine;Ligation;loss of function mutation;Loss of Heterozygosity;Lung;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mediation;member;Metabolic;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Molecular;Mus;Mutate;Mutation;Nerve Degeneration;Neurodegenerative Disorders;novel;Orthologous Gene;overexpression;Oxidation-Reduction;Oxidative Phosphorylation;Oxygen Consumption;Pathway interactions;pharmacologic;Phenotype;Phosphorylation;Phosphorylation Site;Phosphotransferases;PIK3CG gene;Play;Protein-Serine-Threonine Kinases;Proteins;Proteomics;Quality Control;Radiation Tolerance;Reactive Oxygen Species;Regulation;release of sequestered calcium ion into cytoplasm;Reporting;response;Role;Signal Transduction;Site;Site-Directed Mutagenesis;stem;Sterility;Stress;Symptoms;thymocyte;tumor;Yeasts

PROJECT_TITLE: Non-canonical roles for ATM kinase in regulating mitochondrial function and redox homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Nutrition;Obesity;Orphan Drug;Pediatric;Pediatric Cancer;Physical Activity;Prevention;Rare Diseases;Social Determinants of Health;Telehealth

ORG_CITY: CHAPEL HILL

ORG_DEPT: NUTRITION

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Though survivors of adolescent and young adult cancer (AYAs) are at high risk for obesity and related comorbidities, to date there are no behavioral weight management interventions specifically designed to meet the unique needs of this population. Building on our previous trials and pilot data, the proposed study will test the efficacy of digital tools (wireless scales, activity trackers, social networking website) paired with a novel 6- month mHealth weight management intervention adapted for both developmental stage and cancer context, compared to a self-guided arm. If efficacious, this approach to weight management for AYAs has high potential to improve health outcomes, reduce the burden of morbidity in AYAs, and be widely disseminated to AYA survivors across the country.

PI_NAMEs: LAROSE, JESSICA GOKEE;VALLE, CARMINA G (contact)

PROGRAM_OFFICER_NAME: DEAN, DAVID WORTH

PROJECT_TERMS: Acceleration;Accelerometer;actigraphy;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adult;Adverse effects;Aerobic Exercise;Aftercare;Age;aging biomarker;arm;Behavior;behavior change;behavior prediction;Behavioral;Behavioral Mechanisms;Biological Markers;Body Composition;Body mass index;Body Weight Changes;Body Weight decreased;Cancer Survivor;Cardiometabolic Disease;cardiometabolic risk;Cardiovascular Diseases;Clinical;clinical research site;Collection;comorbidity;comparative efficacy;comparison intervention;Competence;Control Groups;Country;Coupled;Data;design;Development;Diabetes Mellitus;Diagnosis;Diet;Diet Monitoring;dietary;Dietary intake;digital data;digital intervention;digital monitoring;digital tool;Education;efficacy evaluation;efficacy testing;Ethnic Origin;evidence base;exercise intervention;Facebook;Feedback;follow-up;food insecurity;Fostering;frailty;Future;Goals;Health;Health behavior change;Health education;health equity;high risk;improved;improved outcome;indexing;Intervention;intervention effect;intervention participants;intrinsic motivation;Late Effects;Life;Life Style;lifestyle intervention;Link;Maintenance;Malignant Neoplasms;Measures;Mediating;Mediator;Mental Depression;mHealth;mhealth interventions;mobile application;Mobile Health Application;Monitor;Morbidity - disease rate;mortality;novel;Obesity;obesity risk;obesogenic;Outcome;Overweight;Participant;Pattern;peer support;Persons;Phase;Physical activity;Population;post intervention;primary outcome;Protocols documentation;psychologic;psychosocial;psychosocial outcome;Quality of life;Questionnaires;Race;Randomized;Randomized, Controlled Trials;Recording of previous events;remote delivery;Research;resistance exercise;response;Risk;Risk Factors;Sampling;secondary outcome;Self Determination;sex;SF-36;social health determinants;social networking website;Subgroup;Survivors;tailored messaging;Telephone;Testing;theories;therapy design;Time;tool;treatment arm;Treatment Efficacy;Treatment Protocols;treatment response;Visit;Vulnerable Populations;waist circumference;web site;weight loss intervention;weight loss program;weight maintenance;Weight maintenance regimen;wireless;young adult

PROJECT_TITLE: Using Tailored mHealth Strategies to Promote Weight Management among Adolescent and Young Adult Cancer Survivors

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE A major impediment to spinal cord regeneration is the failure to clear cellular debris at the injury site, which creates a very unique lipid-dense environment due to abundance of myelin debris. Excessive uptake of lipid in phagocytic cells transforms them into inflammatory cells that contribute to the pathogenesis of SCI. Thus, we propose to investigate the molecular mechanisms the lead to lipid accumulation in foamy macrophages and how they contribute to a fibrotic environment at the injury site.

PI_NAMEs: LEE, JAE K (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Affect;AKT inhibition;Area;Arterial Fatty Streak;Autophagocytosis;Behavioral;Biological Process;Blood Vessels;Cell Aging;cell transformation;Cells;central nervous system injury;Chimera organism;Cicatrix;cytokine;Data;Disease;Environment;experimental study;Failure;Fibroblasts;Fibrosis;Foamy Macrophage;Future;Gene Expression Profile;Gene set enrichment analysis;Goals;Histopathology;IL1R1 gene;In Vitro;in vivo;Inflammatory;inhibitor;Injury;Interleukin-1;Knock-out;Knockout Mice;Lead;Link;Lipid-Laden Macrophage;Lipids;Macrophage;Modeling;Molecular;monocyte;Myelin;new therapeutic target;novel;Pathogenesis;Pathology;Pathway Analysis;Pathway interactions;PDPK1 gene;Phagocytes;pharmacologic;Phenotype;PIK3CG gene;Process;Property;Recovery;regenerative;repaired;Role;senescence;senescence associated secretory phenotype;senescent cell;Signal Pathway;Signal Transduction;Site;Spinal Cord;Spinal cord injury;spinal cord regeneration;Testing;therapeutic development;tissue regeneration;uptake

PROJECT_TITLE: Targeting lipid clearance pathways to promote repair after SCI

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative PUBLIC HEALTH RELEVANCE: Early clinical trials have demonstrated the potential for bNAbs to treat and prevent HIV infection; however, in clinical trials, participants are enrolled without knowledge of their viral susceptibility to bNAbs, which in turn adversely affects bNAb clinical evaluation. We aim to develop accurate assays that measure viral susceptibility to bNAbs at the point-of-care with fast turnaround so that pre-existing and emerging resistance can be identified timely. Such information will greatly impact and improve trials to determine the true efficacy and cutoffs for clinical use of bNAbs.

PI_NAMEs: SHENG, ZIZHANG ;WU, XUELING ;YAMASHITA, MASAHIRO  (contact);YIN, MICHAEL T

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: Address;Affect;AIDS clinical trial group;Algorithms;Antibodies;antiretroviral therapy;Area Under Curve;assay development;Bar Codes;biobank;Biological Assay;Clinical;clinical development;clinical trial enrollment;Clinical Trials;Cloning;Computer Models;Consumption;Data;Detection;Development;Dideoxy Chain Termination DNA Sequencing;DNA;DNA analysis;early phase clinical trial;Enrollment;env Genes;experimental study;Exposure to;Genetic;Genome;Genomic DNA;Genotype;Goals;HIV;HIV envelope protein;HIV Envelope Protein gp120;HIV Infections;HIV Vaccine Trials Network;Human;IgG1;improved;Individual;Infection;Knowledge;Laboratories;Length;Libraries;Link;Literature;Luciferases;machine learning model;Measurement;Measures;Medical center;Minor;Minority;multiplex assay;nanopore;Neutralization Tests;neutralizing antibody;novel;Participant;participant enrollment;Patients;Performance;Peripheral Blood Mononuclear Cell;Persons;Phenotype;point of care;portability;prediction algorithm;Predisposition;prevent;Procedures;Property;Provirus Integration;public health relevance;research clinical testing;Research Personnel;Resistance;Running;Sampling;Site;Societies;System;Technology;Testing;Third Generation Sequencing;Time;Training;Universities;Validation;Variant;Viral;Viral reservoir;viral RNA;Virion;Virus

PROJECT_TITLE: Quick and Accurate Measurements of HIV Broadly Neutralizing Antibody Susceptibility


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Genetics;Human Genome;Immunotherapy;Infectious Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE T cells and B cells are the two crucial components of the adaptive immune system. Next generation sequencing of the T and B cell receptors can be used to profile the T and B cell repertoire (Rep-seq). We hypothesize that understanding the network architecture of the immune repertoire will reveal the role of adaptive immune response to cancer immunotherapy and viral infections. We propose to apply network analysis with advanced statistical approaches and computational techniques on Rep-seq data to unravel how the adaptive immune system is altered by immunotherapy within clinical responders and non-responders and how the adaptive immune system reacts to SARs-Cov-2 virus infection.

PI_NAMEs: ZHANG, LI  (contact)

PROGRAM_OFFICER_NAME: WANG, YANLI

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Adaptive Immune System;Agonist;analysis pipeline;analytical tool;Antibodies;antibody and antigen binding;Antigens;Architecture;B cell repertoire;B-Cell Antigen Receptor;B-Lymphocytes;Bar Codes;Bioinformatics;bioinformatics tool;biomarker discovery;Blood;cancer immunotherapy;Cancer Patient;cancer type;cell type;Cells;Characteristics;Classification;Clinical;clinical prognostic;clinically relevant;Computational Technique;Computer Analysis;Computer software;Coronavirus;COVID-19 patient;Data;Development;Disease;Environment;Epitopes;Esophagogastric Junction;Esophagus;Evaluation;Evolution;feature selection;flexibility;Future;Gene Expression;Generations;Genetic Heterogeneity;genetic signature;Goals;Growth;high dimensionality;Immune;Immune response;Immunodiagnostics;immunogenic;Immunoglobulins;Immunologic Receptors;Immunotherapeutic agent;Immunotherapy;improved;individual response;Infection;Investigation;Joints;Machine Learning;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Methods;Modality;Modeling;Molecular;Nature;network architecture;next generation sequencing;novel;open source;Outcome;Pathway Analysis;Pattern;predictive modeling;Probability;Process;prognostic;Property;Provenge;public repository;Pythons;Reaction;Resolution;respiratory;responders and non-responders;response;Role;single-cell RNA sequencing;Specificity;Specimen;Statistical Methods;T cell response;T-Cell Receptor;T-Lymphocyte;Techniques;Time;TNFRSF5 gene;tool;transcriptomic profiling;tumor;Tumor Immunity;user-friendly;vaccine discovery;Virus Diseases;Visualization;Visualization software

PROJECT_TITLE: Investigation of the landscape of immunosequencing and its clinical relevance through novel immunoinformatic approaches

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Research Narrative  In this submission, we have conveyed our 20-year history as an active and productive Clinical Center within the Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Research Network, our potential for growth, and our commitment to full participation in all current and future MFMU Network studies. Our Case Western Reserve University site joined the MFMU Network in 2001 and now offers all obstetric hospital systems in Cleveland where we will continue our efficient staffing model for recruitment and reproducible data, utilize our knowledge of informatics and the integrated medical records systems across the three sites, and share a collaborative leadership model for region-wide research. The affiliation of all three systems with Case Western Reserve University provides economy of scale in infrastructure, facilitates cross-institutional collaboration locally and within the MFMU Network, and allows us to represent a diverse population with high rates of preterm birth and infant and maternal morbidity to support the NICHD efforts to reduce disparities and answer some of the most pertinent questions in Obstetrics.

PI_NAMEs: GIBSON, KELLY S (contact);RANZINI, ANGELA

PROJECT_TERMS: Adverse event;Antibiotics;Area;Award;Capital;Caproates;Cities;Clinic;Clinical;clinical center;clinical practice;Clinical Research;Clinical Trials;Collaborations;Communities;Conduct Clinical Trials;cost;County;COVID-19;Cytomegalovirus;Data;data quality;Development;Devices;Discipline of obstetrics;disparity reduction;Educational process of instructing;effective intervention;eligible participant;Eugenia;Evaluation;experience;Expert Opinion;Family;fetal;Fetal Heart Rate;Fetus;Financial Hardship;follow-up;Foundations;Future;Goals;Growth;Health Expenditures;Health Policy;Health Service Area;Healthcare Systems;high risk;Hospitals;improved;Individual;infant morbidity;Informatics;Infrastructure;innovation;Institution;Intervention;Knowledge;Lead;Leadership;Location;Marketing;maternal morbidity;Maternal-Fetal Medicine Units Network;Medical;Medical Records;medical schools;member;Methods;metropolitan;Modeling;Molds;Mothers;Multi-site clinical study;Multicenter Studies;National Institute of Child Health and Human Development;Near East;neonatal services;novel therapeutic intervention;Nurses;Observational Study;obstetric services;Ohio;operation;Outcome;Participant;participant retention;Patients;Performance;Pharmaceutical Preparations;Play;Population;Population Heterogeneity;Positioning Attribute;post pregnancy;Poverty;Pregnancy;premature;Premature Birth;Prenatal care;preterm premature rupture of membranes;Privatization;Process;Productivity;Progesterone;Prolonged Pregnancy;Pulse Oximetry;Qualifying;Recording of previous events;recruit;Recruitment Activity;Reproducibility;Reproductive Biology;Research;Research Infrastructure;Research Personnel;Resources;retention rate;Risk;Risk Assessment;Risk Reduction;Role;Services;Side;Site;social;Societies;success;System;tertiary care;Time;Training;Translational Research;Underrepresented Minority;Underrepresented Populations;Universities;University Hospitals;Woman;Work

PROJECT_TITLE: Case Western Reserve University Center of the NICHD MFMU Network


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Rare genetic variants of the essential sarcomere protein titin (TTN) is the most common genetic cause of dilated cardiomyopathy (DCM), a disease characterized by enlargement and weakening of one or both of main chambers of the heart. DCM often progresses to heart failure, a devastating disorder with high morbidity and early mortality, but only limited options are currently available to treat DCM. This proposal aims to determine how TTN gene expression is regulated, augment the amount of TTN expression via genome editing, assess effects of increased TTN protein level on cardiomyocytes with pathogenic TTN variants, and ultimately establish therapeutic strategies for DCM.

PI_NAMEs: KIM, YURI  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: 5' Untranslated Regions;Applied Genetic Engineering;Award;Biological Assay;Biological Models;Cardiac;Cardiac Myocytes;Cardiovascular system;Cells;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;connectin;Conserved Sequence;Data;Development;Dilatation - action;Dilated Cardiomyopathy;Disease;Elements;Engineering;Enhancers;Etiology;Evolution;Foundations;Functional disorder;functional improvement;Funding;gain of function mutation;Gene Expression;Gene Expression Regulation;Genetic;Genetic Engineering;Genetic Transcription;genetic variant;genome editing;genome editor;Genomics;Goals;Heart;Heart Abnormalities;Heart failure;Heart Ventricle;Heterozygote;Hospitalization;Hospitals;Human;human induced pluripotent stem cells;Impairment;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell derived cardiomyocytes;inherited cardiomyopathy;Introns;Investigation;Knowledge;Laboratories;Left;Mediating;medical schools;Medicine;Mentorship;Morbidity - disease rate;mortality;mouse genome;mouse model;Mus;Mutagenesis;mutant;Mutate;Mutation;Myocardial dysfunction;Nucleic Acid Regulatory Sequences;Open Reading Frames;Pathogenesis;Pathogenicity;Patients;Physician Executives;Physiology;Population;Prevalence;prevent;professor;promoter;protein expression;Proteins;recruit;Regulator Genes;Regulatory Element;repaired;Reporter;Research;Role;Sarcomeres;Scientist;screening;Sequence Analysis;Signal Transduction;Site-Directed Mutagenesis;skills;stem;Structure;System;Teaching Hospitals;Technology;Testing;Therapeutic;Transcription Coactivator;Transcriptional Activation;Translations;Variant;Ventricular;Woman;Work

PROJECT_TITLE: Development of strategies to enhance titin (TTN) expression and treat dilated cardiomyopathy caused by TTN haploinsufficiency

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Somatic mutations (genomic variants that occur after conception) have long been known to be an important cause of cancer, but recent research has found that they are also responsible for a range of other human disorders as well as phenotypic variations between individuals. The overall goal of the Somatic Mosaicism across Human Tissues (SMaHT) Network is to gain a better understanding of how somatic mutations influences biology and disease. As part of the SMaHT network, the goal of our project is to develop better and cheaper methods of detecting somatic mutations that are likely to influence human biology.

PI_NAMEs: PARK, PETER J;WALSH, CHRISTOPHER A. (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;age related;Algorithms;Alleles;ATAC-seq;base;Benchmarking;Binding;Biology;blastocyst;Brain;brain tissue;Cancer Etiology;Catalogs;Cell division;cell type;Chromatin;Chromatin Structure;Computer software;computerized tools;Conceptions;cost;Cost Analysis;cost effective;Data;Data Set;design;Detection;detection method;Development;Disease;disorder risk;DNA;DNA purification;DNA Repair;DNA sequencing;Genetic Enhancer Element;genetic variant;Genome;genome sequencing;Genomic Segment;Genomics;Goals;Human;Human Biology;human tissue;improved;Individual;large datasets;Malignant Neoplasms;Methods;Modification;mosaic;Mosaicism;Mutagens;Mutate;Mutation;Mutation Detection;Normal tissue morphology;Nucleic Acid Regulatory Sequences;Phase;Phenotype;promoter;Protocols documentation;Publishing;Recurrence;Research;Sampling;scale up;Sensitivity and Specificity;Site;Somatic Mutation;targeted sequencing;Techniques;Technology;technology development;Testing;Tissue Microarray;Tissues;tool;Training;transcription factor;Untranslated RNA;Validation;Variant;whole genome

PROJECT_TITLE: Development of an Efficient High Throughput Technique for the Identification of High-Impact Non-Coding Somatic Variants Across Multiple Tissue Types

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-K(70)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The protected time and resources provided through this K24 mid-career mentoring award will enhance my ability to recruit and train patient-oriented researchers focused on addressing obesity and improving care of vulnerable patients with obesity. The research aims, focused on evaluating the impact of social determinants of health on weight management, will provide additional opportunities for me and my trainees to obtain additional expertise in social determinants of health and community-engaged research. With guidance from my K24 Advisory Committee and hands-on training, I will enhance my skills in recruiting and mentoring trainees from all backgrounds to enhance their training, support their individual research, and improve the care of vulnerable patients with obesity.

PI_NAMEs: JAY, MELANIE  (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Active Learning;Address;Adult;Advisory Committees;Area;Award;bariatric surgery;Behavioral;behavioral clinical trial;black patient;Black race;Body Weight Changes;Body Weight decreased;cardiometabolic risk;career;Caring;cohort;Cohort Studies;Collaborations;Communities;community advisory board;community collaboration;community engaged research;community engagement;Community Health;comparison control;Data Set;deprivation;design;Discrimination;Disparity;Environment;Evaluation;experience;Faculty;Feedback;Funding;Grant;Health;health difference;health disparity;health equity;health equity promotion;Health equity research;Hispanic;improved;Individual;interest;Intervention;intervention delivery;intervention participants;intervention program;Intervention Studies;Intervention Trial;K-Series Research Career Programs;Leadership;Learning;Measures;member;Mentors;Mentorship;Mid-Career Clinical Scientist Award (K24);Minority Groups;minority trainee;Modeling;National Heart, Lung, and Blood Institute;Neighborhoods;next generation;obese patients;Obesity;Outcome;Participant;participant enrollment;Patient Education;patient engagement;patient oriented;patient oriented research;patient population;Patient Recruitments;Patients;Population;Postdoctoral Fellow;Primary Care;Process;programs;Race;racial discrimination;recruit;Research;Research Personnel;Resources;Risk;skills;social health determinants;Social Interaction;Strategic vision;Structural Racism;Students;surgery outcome;symposium;Testing;Time;Training;Training Support;Underrepresented Minority;United States Department of Veterans Affairs;United States National Institutes of Health;Vulnerable Populations;Weight;Weight maintenance regimen;Work

PROJECT_TITLE: Mentoring the next generation of trainees in patient-oriented, community engaged research in obesity and health equity

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

PHR: The pressing need to distinguish potentially lethal from indolent prostate cancer is usually approached by attempting to identify genomic predictors in the malignant epithelial tissue. However, from extensive cell biology research, it is known that the microenvironment plays a critical role in cancer progression, though a deeper understanding of the mechanism is needed. In this proposal, we will study gene expression of the prostate microenvironment to improve the understanding of its impact on the biology of the tumor and to augment previously proposed genomic predictors of lethal prostate cancer by developing a gene expression signature from the stromal tissue.

PI_NAMEs: BIRMANN, BRENDA M (contact);TYEKUCHEVA, SVITLANA

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Address;Affect;Area;Attention;Behavior;Bioinformatics;Biological Markers;Biology;biomarker development;Biopsy Specimen;Cancer Biology;cancer diagnosis;Cancer Etiology;Cancer Patient;cancer subtypes;cancer survival;cell stroma;cell type;Cellular biology;Cessation of life;clinical care;cohort;Data;Development;Diagnosis;differential expression;Disease;DNA Sequence Alteration;Endothelial Cells;Epithelium;Fibroblasts;Fluorescence;Follow-Up Studies;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic Risk;Genetic Transcription;genetic variant;genome-wide;genomic predictors;Germ Lines;Gleason Grade for Prostate Cancer;Health;Health Professional;Immune;Immunohistochemistry;improved;Indolent;Inflammation;Inherited;innovation;Lasers;Link;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;men;Molecular;molecular marker;molecular subtypes;Morphology;Motility;Mutation;Neoplasm Metastasis;Outcome;overtreatment;Pathologic;Pathway interactions;Patients;Pattern;Physicians;Pilot Projects;Play;predictive signature;Prognosis;prognostic;prognostic assays;Prognostic Marker;programs;Proliferating;Property;Prostate;prostate biopsy;prostate cancer cell;prostate cancer risk;Prostatic Neoplasms;Quantitative Trait Loci;Radical Prostatectomy;Research;Research Personnel;Risk;risk variant;Role;Signal Transduction;Smooth Muscle;Specimen;Stains;Stromal Cells;synergism;targeted treatment;Testing;Tissue Microarray;Tissue Stains;Tissues;tumor;Tumor Biology;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;Work

PROJECT_TITLE: Comprehensive characterization of prostate stromal gene expression and association with lethal prostate cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: SALT LAKE CITY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: DNA methylation patterns are dysregulated in many human diseases, suggesting that elements of disease initiation may be common across diseases. The proposed research aims to characterize pan-disease patterns of methylation dysregulation and to identify genes and regulators that lead to methylation dysregulation. This will contribute to fundamental knowledge of disease initiation and identify potential targets for disease diagnosis and treatment.

PI_NAMEs: CLEMENT, KENDELL  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Affect;Aging;Autoimmune Diseases;Biological Assay;Characteristics;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Computational algorithm;cost;CRISPR screen;Data;Data Set;Databases;Development;Diagnostic;diagnostic biomarker;Disease;disease diagnosis;disease model;disease phenotype;DNA Methylation;DNA Methylation Regulation;DNA Sequence Alteration;Early Diagnosis;Early Intervention;Elements;Enzymes;Epigenetic Process;epigenome;experience;Experimental Designs;Fingerprint;Gene Expression;Generations;Genes;Genetic;Genome;genome analysis;genomic variation;Genomics;Goals;Health;high throughput screening;human disease;Investigation;knockout gene;Knowledge;large datasets;Link;Machine Learning;Malignant Neoplasms;Mental disorders;Metabolic Diseases;Metabolic Pathway;Methylation;methylation pattern;Modeling;Mutate;Mutation;novel;novel strategies;Pathway interactions;Patients;Pattern;Play;Process;Regulation;Regulatory Element;Reporting;Reproducibility;Research;Research Personnel;Role;Sample Size;Sampling;Scientist;Severity of illness;Technology;Therapeutic;Therapeutic Intervention;therapeutic target;Tissue Sample;Tissues;Training;transcriptome;treatment response;Untranslated RNA;Validation;Variant

PROJECT_TITLE: Pan-disease characterization of DNA methylation dysregulation

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Obesity-associated asthma affects approximately 8 million adults in the United States. Obese adults with late- onset, nonatopic asthma experience more severe symptoms and fewer days of asthma control, resulting in increased asthma-related hospitalizations and reduced quality of life. This proposal will improve treatment options for obesity-associated asthma by developing the microbiome-metabolome and its involvement in inflammatory signaling along the gut-lung axis as a novel targeted therapy.

PI_NAMEs: HEINRICH, VICTORIA  (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acids;Adrenal Cortex Hormones;Adult;adult obesity;Affect;Aftercare;Age;airway hyperresponsiveness;Airway Resistance;allergic airway disease;American;Anti-Inflammatory Agents;Antibiotics;Asthma;asthma exacerbation;asthma inhaler;asthmatic patient;Attenuated;B-Cell Activation;Bacteria;Blood capillaries;Body mass index;Bronchoalveolar Lavage Fluid;Carbon;Cecum;Cell Count;chemokine;Childhood;Circulation;Clinical;Clinical Management;clinical phenotype;cytokine;Data;diet-induced obesity;dietary control;Disease;Disease remission;Drug Kinetics;Emergency Care;Enhancers;experience;Extrinsic asthma;Family;Fatty Acids;Frequencies;Gene Expression;Goals;gut microbes;gut microbiome;gut microbiota;gut-lung axis;High Fat Diet;Hospitalization;Immune;improved;Inflammation Mediators;Inflammatory;inflammatory modulation;Inflammatory Response;Label;Life;Light;Lung;Mass Spectrum Analysis;Measures;Mediator;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;metatranscriptomics;Methods;microbial;microbial host;microbiome;microbiome composition;microbiota;microbiota composition;Morbidity - disease rate;mortality;mouse model;Mus;new therapeutic target;Nuclear;nuclear factor-erythroid 2;obese patients;obese person;Obesity;obesity treatment;obesity-associated asthma;obesogenic;Oleic Acids;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Potato;Production;pulmonary function;Quality of life;Research;Resolution;response;Risk;RNA;Role;Serum;Severities;Signal Pathway;Signal Transduction;Source;stable isotope;Starch;stool sample;Structure of parenchyma of lung;symptom management;Symptoms;systemic inflammatory response;targeted treatment;Techniques;Testing;TNF gene;transcription factor;Translating;treatment response;United States;Visceral fat;Volatile Fatty Acids

PROJECT_TITLE: Developing the microbiome-metabolome as a targeted therapy for obesity-associated asthma


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Osteoporosis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DAVIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The escalating frequency of osteoporosis, fractures, and cartilage defects are a major health burden of our modern society. Loss of skeletal integrity and regeneration capacity through aging underlies a detrimental shift of bone formation and resorption dynamics originating from the skeletal stem cell (SSC) compartment. This proposal aims to mechanistically investigate age-related changes of SSC heterogeneity as well as the role of an unexplored age-related stem cell-regulating factor which, if properly understood, could be instrumental to provide new therapeutic avenues for the alleviation of these emerging medical challenges.

PI_NAMEs: AMBROSI, THOMAS HANS (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Address;adult stem cell;age related;age related changes;aged;Aging;American;Amines;Anatomy;ATAC-seq;bone;bone aging;Bone Diseases;Bone Resorption;Cartilage;Cell Communication;Cell Compartmentation;Cell Lineage;Cells;cellular imaging;Death Rate;Defect;Development;Diagnostic;Elderly;Environment;Epigenetic Process;experimental study;Fracture;Frequencies;functional decline;Functional disorder;functional restoration;Health;Heterogeneity;Hip Fractures;Homeostasis;Impairment;In Vitro;in vitro Assay;in vivo;Incidence;Injury;Institution;Label;Limb structure;Link;long bone;Mediating;Medical;Methods;Modernization;Molecular;Morbidity - disease rate;Mus;nano-string;novel;novel therapeutics;Osteogenesis;Osteoporosis;Pathway interactions;Phase;Preventive;Proteins;Proteomics;Public Health;receptor;regeneration following injury;regenerative;regenerative approach;Regenerative capacity;Reporting;Research;Role;side effect;Signal Pathway;single cell analysis;single-cell RNA sequencing;skeletal;skeletal disorder;skeletal stem cell;skeletogenesis;Societies;Source;Spatial Distribution;spatiotemporal;stem cell aging;stem cell population;stem cells;Testing;Therapeutic;Time;transcriptomics;Transplantation

PROJECT_TITLE: Reversing Skeletal Aging by Restoring Functional Skeletal Stem Cell Diversity


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The most common cause of Amyotrophic Lateral Sclerosis (Lou Gehrig’s disease, ALS) and Frontotemporal Dementia is a repetitive element within the gene C9orf72. This repeat causes disease at least in part by producing toxic proteins through an unusual process known as RAN translation. This proposal will use biochemical techniques, neurons, and multiple model systems- including patient derived induced pluripotent stem cell models, to understand how RAN translation works and how it might be selectively targeted in patients.

PI_NAMEs: TODD, PETER K (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Amyotrophic Lateral Sclerosis;Behavior;Biochemical;Biological;Biological Models;c9FTD/ALS;C9ORF72;Cells;Cellular Stress;Codon Nucleotides;Complementary DNA;Complex;Data;Dipeptides;Disease;Event;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;G-Quartets;Genes;Genetic;Genetic Transcription;Goals;Human;In Vitro;in vivo;Initiator Codon;insight;Introns;Measures;Messenger RNA;Modeling;mRNA capping;multicatalytic endopeptidase complex;Nature;Neurons;neurotoxicity;novel;Pathogenesis;Pathologic;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phenotype;Play;Polyribosomes;Positioning Attribute;Process;Production;Proteins;Quality Control;Reading Frames;Repetitive Sequence;Ribosomes;RNA;RNA Helicase;RNA-Binding Proteins;Rodent;Role;stem cell model;Structure;System;Techniques;therapeutic development;therapeutic target;Transcription Initiation;Translating;Translation Initiation;Translations;Ubiquitin;Work

PROJECT_TITLE: Hexanucleotide repeat translation in ALS and Frontotemporal Dementia

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: CHAMPAIGN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Project Narrative The incidence of infertility is on the rise, affecting nearly 20% of the couples in the reproductive age group. Male infertility contributes to approximately half the number of cases, yet, the reasons for male infertility are not known. This project will develop a novel mouse line that enables researchers to probe the mechanisms of male infertility; it will also reveal whether TDP-43, known to cause human pathology, plays a role in the proper formation of spermatozoa.

PI_NAMEs: REDDI, PRABHAKARA P (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Acrosome;Adult;Affect;age group;Alleles;Biogenesis;Biology;Breeding;cell type;Chromatin;Complementary DNA;conditional knockout;Couples;DNA;Ectopic Expression;Enterobacteria phage P1 Cre recombinase;Excision;Feasibility Studies;Funding Opportunities;Gene Expression;Gene Order;Generations;Genes;Genotype;Germ Cells;Glycine;Goals;Haploid Cells;Histopathology;Human Pathology;improved;Incidence;Infertility;innovation;integration site;Knockout Mice;LoxP-flanked allele;male;male fertility;Male Infertility;Meiosis;Meiotic Prophase I;Modeling;Mus;Names;novel;Nuclear;Nuclear Localization Signal;offspring;Phenotype;Physical condensation;Pilot Projects;prevent;promoter;Property;Protamines;protein TDP-43;red fluorescent protein;Reporter;Reporter Genes;reproductive;Research;Research Personnel;Resources;Reverse Transcriptase Polymerase Chain Reaction;RNA Recognition Motif;RNA-Binding Proteins;Role;Signaling Protein;spatiotemporal;Specificity;sperm cell;sperm morphology;Sperm Motility;Spermatids;Spermatocytes;Spermatogenesis;Spermatogonia;Spermiogenesis;SPO11 gene;Tars;Technology;Testing;Testis;Tissues;transcription factor;Transgenes;Transgenic Mice;Transgenic Organisms;Work

PROJECT_TITLE: Generation of a new Cre-deleter mouse line to study spermiogenesis

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE In disease, the heart is unable to pump a sufficient amount of blood to meet the metabolic demands of the body. We have identified a novel signaling mediated phosphorylation to increase cardiac contraction that this study will establish as beneficial to improve heart function in disease and that is without long-term detrimental effects. The data generated from this proposal will be critical towards informing future novel therapeutic approaches to improve cardiac contraction and the insufficient heart function that is at the root of heart disease.

PI_NAMEs: BIESIADECKI, BRANDON J (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: 5'-AMP-activated protein kinase;Actins;Action Potentials;Anterior Descending Coronary Artery;Arrhythmia;Blood;blood pump;Calcium;Calcium Signaling;Cardiac;Cardiac Muscle Contraction;Cardiac Myocytes;cardiac tissue engineering;cost;Coupling;Data;Development;Diameter;Disease;Dobutamine;Echocardiography;EFRAC;Electrocardiogram;Electrophysiology (science);Exercise Tolerance;exhaustion;Exhibits;Future;genetic regulatory protein;Heart;Heart Diseases;heart function;hemodynamics;Histology;Human;Human Engineering;human induced pluripotent stem cells;human tissue;Impairment;improved;in vivo;Infarction;Left;Left Ventricular Ejection Fraction;Ligation;Measurement;Measures;Mediating;Metabolic;Microfilaments;Milrinone;mimetics;Modification;Molecular;Morphology;mortality;Mus;Muscle Cells;Muscle Contraction;Muscle function;Myocardial dysfunction;Myocardial Infarction;Myocardium;Myosin ATPase;novel;novel therapeutic intervention;Oxygen Consumption;Phosphorylation;pressure;protein expression;Proteins;Proteomics;Pump;Relaxation;Role;Safety;Signal Transduction;Site;Skin;tau Proteins;Testing;Therapeutic;Tissues;Translating;treadmill;Troponin I;Ventricular;Wild Type Mouse;Work

PROJECT_TITLE: Troponin I phosphorylation as a novel novel cardiac inotrope

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative. The validation and implementation of efficient, cost-effective screening tools that can accurately detect the earliest stages of Alzheimer’s disease (AD) in primary care settings is of paramount importance for the advancement of AD clinical care and prevention research. The objective of this study is to assess the feasibility, reliability and validity of novel digital cognitive screening tools for remote and in-clinic assessment. Our goal is to advance new technologies that are sensitive to detect subtle AD-associated cognitive decline, require minimal training to administer, have low patient burden, and are acceptable and accurate in diverse older adult populations.

PI_NAMEs: THOMPSON, LOUISA  (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Acceleration;acceptability and feasibility;Adult;Aging;Algorithms;Alzheimer disease screening;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;amnestic mild cognitive impairment;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Area;baby boomer;Biological Markers;Biometry;Black race;Blood;career;career development;Cellular Phone;Clinic;Clinical;clinical care;clinical outcome assessment;Clinical Research;Cognition;Cognitive;cognitive change;cognitive function;cognitive performance;cognitive testing;Cohort Studies;Communities;Consent;cost effective;cost efficient;Coupled;COVID-19 pandemic;Data;Data Analyses;Dementia;Detection;Development;Development Plans;Devices;Diagnosis;Diagnostic;digital;digital tool;Disparity;Early Diagnosis;Early treatment;Eligibility Determination;Enrollment;ethnic minority;Ethnic Origin;Ethnic Population;Evaluation;experience;feasibility testing;Feedback;flexibility;follow-up;Funding;Goals;Health;health care settings;Health Personnel;Hematological Disease;Hispanic;Home;Hospitals;Impaired cognition;implementation science;improved;Individual;Insurance;Internet;Intervention;Interview;Knowledge;Latino;Licensing;Machine Learning;Measurement;Measures;Medicare;Memory;Mentorship;Methods;minimally invasive;mobile application;Monitor;multimodality;neuroimaging marker;new technology;novel;older adult;Outcome;outreach;Paper;Participant;patient home care;Patients;Performance;Persons;Plasma;Population;Population Heterogeneity;Positron-Emission Tomography;pre-clinical;Prevention Research;Primary Care;primary care clinic;primary care practice;primary care setting;Principal Investigator;professor;programs;Protocols documentation;Provider;Psychometrics;racial minority;racial population;randomized, clinical trials;recruit;Reference Standards;remote screening;Research;Research Assistant;Research Design;Research Personnel;Risk;Sampling;screening;Screening procedure;Self Administration;skills;Spanish;Specificity;Standardization;Statistical Methods;Structure;Surveys;Tablets;tau Proteins;tau-1;Telephone;Testing;Time;tool;Training;trial design;Underrepresented Populations;United States National Institutes of Health;Validation;Validity and Reliability;Visit;wellness visit

PROJECT_TITLE: Accelerating digital cognitive screening for Alzheimer's disease in the Primary Care Setting

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Infant Mortality;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The Maternal Fetal Medicine Units (MFMU) Network performs clinical trials that provide for improved care and treatment of pregnant people and their fetuses; thus, allowing for improved outcomes in maternal and child health. The clinical research environment in the Department of Obstetrics and Gynecology at Penn is exciting and continually growing, and the outstanding leadership team of the MFMU Network clinical center at Penn reflects a strong commitment for ongoing engagement by the department in the MFMU Network. The investigative team at Penn has built a highly successful MFMU Network clinical site that will support the NICHD's guiding principles shaping the 21st century landscape for multi-site clinical research, including enhanced rigor for selecting studies, availability of Network infrastructure to a wider range of investigators, data sharing and access to biospecimens, and inclusion of diverse populations in Network studies.

PI_NAMEs: PARRY, SAMUEL I. (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Ancillary Study;Area;Biological Specimen Banks;Caring;Clinical;clinical center;Clinical Data;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;cohort;Collaborations;Collection;Computerized Medical Record;Conduct Clinical Trials;Data;data access;data repository;data sharing;Development;Discipline of obstetrics;Disparity;disparity reduction;Enrollment;Ensure;Environment;Equity;Ethnic Origin;experience;Faculty;Fetus;follow-up;Functional disorder;Funding;Genetic;Genomics;Goals;Good Clinical Practice;Gynecology;Health system;Heart;high risk;High-Risk Pregnancy;Hospitals;Hypertension;improved;improved outcome;innovation;Intervention Studies;Leadership;Longterm Follow-up;Manuals;Maternal and Child Health;maternal outcome;Maternal-fetal medicine;Maternal-Fetal Medicine Units Network;Medical Records;Modeling;Multicenter Neonatal Research Network;Multicenter Studies;Multicenter Trials;National Institute of Child Health and Human Development;Neonatal;neonatal outcome;Network Infrastructure;Nurses;Observational Study;obstetric services;operation;Operations Research;Outpatients;participant enrollment;patient population;Patients;Pediatric Hospitals;Pennsylvania;Performance;Persons;Phase;Philadelphia;Placenta;Population;Population Heterogeneity;Positioning Attribute;Post-Acute Sequelae of SARS-CoV-2 Infection;Postpartum Hypertension;Postpartum Women;pregnant;Pregnant Women;premature;Premature Birth;programs;Proteomics;Protocols documentation;Publications;Publishing;racial diversity;randomized trial;randomized, clinical trials;recruit;Registered nurse;Regulatory Affairs;reproductive;Research;Research Infrastructure;Research Personnel;Second Labor Stage;Shapes;shared database;Site;support network;Text;Translational Research;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities;University Hospitals;Women's Health;Work;Writing

PROJECT_TITLE: NICHD Maternal-Fetal Medicine Units (MFMU) Network: Clinical Center


NIH_SPENDING_CATS: Anxiety Disorders;Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Rehabilitation;Serious Mental Illness

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative This is a small clinical trial of a new brain stimulation intervention for obsessive-compulsive disorder (OCD). We will use implanted electrodes to stimulate two brain areas related to OCD in a way that should specifically de-synchronize them, while also recording the electrical activity of the brain in response to stimulation. If successful, we will have both a new treatment for OCD and will also learn how the brain's electrical activity changes when stimulation is applied, which should help design better treatments for OCD and other psychiatric disorders.

PI_NAMEs: DOUGHERTY, DARIN D (contact);WIDGE, ALIK S.

PROGRAM_OFFICER_NAME: FRANKOWSKI, MEGAN MICHELLE

PROJECT_TERMS: Address;Affect;Animal Model;Anxiety;Area;Automobile Driving;Behavior;Behavior Disorders;Belief;Bilateral;Biological Markers;biomarker identification;blind;Brain;brain electrical activity;capsule;caudate nucleus;Chronic;Clinical;Clinical Trials;compulsion;conditioned fear;Corpus striatum structure;Data;Deep Brain Stimulation;design;Disease;dynamic system;Electric Stimulation;Electrodes;Electroencephalography;Elements;Event;Event-Related Potentials;experience;Extinction;Feedback;Flare;Frequencies;Fright;Functional Magnetic Resonance Imaging;Goals;Grooming;Habits;Hand functions;Human;Implanted Electrodes;improved;Interruption;Intervention;Lead;Learning;Lesion;Link;Macaca;Mediating;Mental Depression;Mental disorders;Modeling;Monitor;Motivation;Motor;Neurobiology;neuroimaging;Neurosciences;Neurosurgeon;neurosurgery;new technology;novel therapeutics;Obsession;Obsessive compulsive behavior;Obsessive-Compulsive Disorder;Operative Surgical Procedures;Outcome;Pathologic;Patient Participation;Patients;Persons;Pharmaceutical Preparations;Phase;pilot test;potential biomarker;Procedures;Protocols documentation;Psychiatrist;Psychophysics;Research Domain Criteria;Research Personnel;Resistance;response;Rest;Rewards;Rodent;Safety;safety and feasibility;severe mental illness;Severities;Signal Transduction;simulation;Site;Surface;symptomatic improvement;Symptoms;Syndrome;System;Systems Theory;Testing;theories;therapy development;Thinking;Time;treatment response;trial design;Ventral Striatum;Work

PROJECT_TITLE: Combined Cortical and Subcortical Recording and Stimulation as a Circuit-Oriented Treatment for Obsessive-Compulsive Disorder


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Eye Disease and Disorders of Vision;Wound Healing and Care

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Microbial keratitis, or infectious corneal ulceration, is a leading cause of corneal blindness but is difficult to objectively measure. Developing objective, reproducible, and clinically relevant outcome metrics for microbial keratitis would improve the clinical applicability and statistical power of future studies. This study uses multimodal imaging on a cohort of patients with microbial keratitis to compare different modalities’ measurements of corneal thinning, assess evolution of corneal scar density in microbial keratitis, and evaluate whether certain early clinical and anatomic features can improve prediction of visual outcomes in microbial keratitis.

PI_NAMEs: SHEKHAWAT, NAKUL  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Affect;Anatomy;Anterior;Applied Research;Area;Biological;Biometry;Blindness;career development;Categories;Characteristics;Cicatrix;Clinical;clinical application;Clinical assessments;clinical care;clinical practice;Clinical Research;clinical trial implementation;Clinical Trials;clinically relevant;cohort;comparative efficacy;comparison group;Conduct Clinical Trials;Cornea;Corneal Diseases;corneal scar;Corneal Ulcer;Data;Densitometry;density;design;Disease;Educational workshop;Enrollment;Environment;Evidence based treatment;Evolution;experience;Eyeglasses;follow-up;Funding;Future;Goals;health care settings;Heterogeneity;imaging modality;improved;improved outcome;India;Individual;Infection;innovation;insight;K-Series Research Career Programs;Keratitis;Measurement;Measures;Mentors;Mentorship;Methodology;microbial;microbial based therapy;Modality;Modeling;Monitor;Multi-Institutional Clinical Trial;Multimodal Imaging;Natural History;new technology;novel;Optical Coherence Tomography;Outcome;Outcome Assessment;patient population;Patients;Persons;Population;Prognosis;prospective;Prospective Studies;Prospective, cohort study;Quality of life;randomized trial;Reproducibility;Research;research study;Sample Size;Scientist;Severities;slit lamp imaging;Statistical Models;Statistical Study;Stratification;Structure;Subgroup;sugar;Thinness;Time;tomography;Training;Treatment Efficacy;treatment response;ultrasound;Universities;Vision;Visual;Visual Acuity

PROJECT_TITLE: Improving Outcomes Assessment for Microbial Keratitis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Pediatric;Substance Misuse

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: The proposed research is relevant to public health because it involves experiments pertinent to the question of whether 1.5 million infants and toddlers who receive general anesthetics as part of early procedures may be at risk for developing mood and addiction disorders as adults, and identifies a pharmacologically-targetable molecular substrate for the observed circuit-level and behavioral changes in exposed populations. The project is relevant to NIH's mission because it 1) identifies basic processes in terms of the long-lasting effects of a specific class of drugs on the body that have implications for multiple disease areas, 2) delineates the consequences of these effects for circuit function and behavior as an output of the activity of this specific circuit, providing a path for early intervention strategies for mental illness and drug addiction resulting from the identified disruptions in the studied molecules, circuits and behaviors.

PI_NAMEs: ENGIN, ELIF  (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TERMS: addiction;Address;Adult;Affect;Age Years;alcohol exposure;Alcoholism;Alcohols;Anesthetics;Anhedonia;Animals;Anti-Anxiety Agents;anti-epileptic agents;Anxiety;Anxiety Disorders;Area;Behavior;Behavioral;behavioral study;Benzodiazepines;Biological Models;Birth;Brain;brain shape;Cells;Child;Chronic;Chronic stress;Controlled Study;Corpus striatum structure;Data;Development;Diffuse;disability;Disease;Drug abuse;Drug Addiction;Drug Exposure;drug of abuse;drug reward;Early Intervention;Emotional;emotional behavior;Environment;Etiology;experimental study;Exposure to;Female;follow-up;GABA Agonists;gamma-Aminobutyric Acid;General anesthetic drugs;Genetic;Hand;Human;hypnotic;Individual;Infant;Inflammation;innovation;Interneurons;Intervention;Isoflurane;Knowledge;Link;Long-Term Effects;Mediating;Mental Depression;Mental disorders;Messenger RNA;Mission;Modeling;Molecular;Mood Disorders;Moods;Motivation;mouse model;mRNA Expression;Mus;Natural experiment;neglect;Neurons;neurotransmission;nonhuman primate;novel;Nucleus Accumbens;nursing mothers;optogenetics;Outcome Study;Output;Pattern;Perinatal;Perinatal Exposure;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physiological;Population;Positioning Attribute;postnatal;postnatal development;Predisposition;Pregnant Women;prenatal;Procedures;Process;Protein Analysis;protein expression;Public Health;receptor;receptor expression;Recreation;Reporting;Research;reward circuitry;Rewards;Risk;Risk Factors;sedative;single cell proteins;social;Social Behavior;Specificity;Stress;stressor;Symptoms;System;Techniques;Therapeutic;Therapeutic Uses;Toddler;trafficking;United States National Institutes of Health;Withdrawal;Work

PROJECT_TITLE: Disruptions in the brain reward system through postnatal exposure to GABA agonists and anesthetics

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Genetics;Mental Health

ORG_CITY: Boulder

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF COLORADO

PHR: PROJECT NARRATIVE This research education meets the need for training in methods of statistical genetics for mental health researchers working with genome wide association studies, next generation sequencing studies, and twin and family studies of genetic and environmental influences on mental illnesses. The introduction of new techniques of statistical and computational genetics, and the increasing interest in the methodology for identifying the genes influencing complex traits, has created an enormous demand for this training.

PI_NAMEs: KELLER, MATTHEW CHARLES (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Area;Behavioral;Behavioral Genetics;Characteristics;Code;Collaborations;Complex;Conscious;cost;Data;Data Set;design;Development;early-career faculty;Education;education research;Educational Curriculum;Educational Materials;Educational process of instructing;Educational workshop;Equation;Equilibrium;Evaluation;experience;Family;Family Study;Feedback;flipped classroom;Fruit;Funding;Future;Genes;Genetic;Genetic study;Genome;genome wide association study;graduate student;Heritability;Human;innovation;interest;International;Learning;lectures;Libraries;Measures;Medical Students;meetings;Mental disorders;Mental Health;Methodology;Methods;Mission;Modeling;Modernization;Molecular Genetics;National Institute of Mental Health;next generation sequencing;Paper;Participant;Persons;Postdoctoral Fellow;programs;Quantitative Genetics;Recording of previous events;repository;Request for Proposals;Research;Research Personnel;response;Rotation;Scientist;skill acquisition;skills;statistical learning;Statistical Methods;Strategic Planning;Structure;Students;synergism;Techniques;Time;Training;trait;Twin Multiple Birth;Twin Studies;Update;Variant;virtual;web site;Work

PROJECT_TITLE: Workshop on Statistical Genetic Methods for Human Complex Traits


NIH_SPENDING_CATS: Neurosciences;Nutrition

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative All-trans Retinoic acid (atRA), the biologically active form of Vitamin A, acts to regulate genome program by activating RA receptors, known as canonical activity, and to elicits non-canonical activities recently identified in multiple physiological processes via CRABP1. The long-term goal of this project is to comprehensively understand how vitamin A (atRA) affects health and diseases. The current proposal focuses on the non- canonical atRA signaling mediated by Crabp1 to modulate CaMKII signaling in excitable cells such as motor neurons, which is essential to the health of neural muscular junction and motor function.

PI_NAMEs: WEI, LI-NA  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: 3-Dimensional;Affect;age related;Amyotrophic Lateral Sclerosis;antagonist;Biological;Ca(2+)-Calmodulin Dependent Protein Kinase;Calmodulin 1;calmodulin-dependent protein kinase II;Cardiac Myocytes;Cell Physiology;Cells;cellular retinoic acid binding protein;cellular targeting;chromatin remodeling;Custom;Cytoplasm;Data;Defect;Degenerative Disorder;Deterioration;Development;Disease;embryonic stem cell;Engineering;Ensure;Environment;Future;Genome;Goals;Grant;Health;Hydrogels;In Vitro;in vivo;Inflammation;Knockout Mice;Ligands;Mediating;Mediator;MEKs;Modeling;Molecular;Molecular Conformation;Molecular Mechanisms of Action;molecular modeling;Morphology;Motor;motor deficit;motor function improvement;Motor Neurons;motor symptom;Muscle;nerve stem cell;neural;Neuromuscular Junction;Nuclear Receptors;Obesity;orphan nuclear receptor TR2;Paper;Pathologic;Pathway interactions;Physiological;Physiological Processes;programs;Publishing;raf-1 Protein;Regulation;Reporting;Retinoic Acid Receptor;RXR;Severities;Signal Pathway;Signal Transduction;stem cells;Stress;System;Therapeutic;Tretinoin;Vitamin A

PROJECT_TITLE: TR2 nuclear receptor in vitamin A signaling

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


PHR: Osteocalcin is proposed, based on studying one knockout mouse strain, to be a potent, bone-expressed, hormone that affects glucose metabolism, fat storage, muscle mass, cognition, and fertility. However, the robustness and reproducibility of these effects is now questioned by their absence in 2 other osteocalcin knockout mouse strains. Because of osteocalcin’s potential importance as a therapeutic agent, drug target, and biomarker in human health and disease, it is essential to understand the basis for discrepant phenotypes among different osteocalcin knockout mice.

PI_NAMEs: WARMAN, MATTHEW L (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Affect;African American;age-related muscle loss;Aging;Alleles;American;Animal Behavior;Animals;Apatites;Behavioral;Biological;Biological Markers;Biological Process;Biology;bisphosphonate;Blinded;Blood Glucose;Body mass index;bone;Bone Density;bone mass;bone strength;Boston;Brain;brain malformation;Child;Cognition;cohort;college;conflict resolution;Cultured Cells;Data;Deposition;Development;Diabetes Mellitus;Diet;Dietary intake;Disease;Drug Targeting;Ear;Endocrine;Energy Metabolism;Ensure;Environment;Environmental Exposure;Evolution;experimental study;Failure;fascinate;Fatty acid glycerol esters;Fertility;fighting;follower of religion Jewish;Funding Agency;Genetic;Genetic Variation;genome wide association study;Genotype;Glucose;Glucose Clamp;glucose metabolism;glucose tolerance;Glycosylated hemoglobin A;Grant;Health;Hormonal;Hormones;Hospitals;Human;Human Resources;Hydroxyapatites;Hyperglycemia;Impaired cognition;Impairment;Individual;Induced Mutation;inhibitor;Insulin;Insulin Resistance;Investments;Journals;Knock-out;Knockout Mice;Laboratories;Learning;Letters;Literature;loss of function;loss of function mutation;male fertility;Manuscripts;Measures;medical schools;Medicine;Metabolic;metabolic abnormality assessment;metabolic phenotype;Metabolism;microbiome;Minerals;Morphology;Mouse Strains;Mus;Muscle;muscle form;nanoindentation;Nature;Neurologic;novel;Osteocalcin;Patients;Pediatric Hospitals;Peer Review;Pharmacologic Substance;Phenotype;phenotypic data;Physiology;Population;Post-Translational Protein Processing;Production;programs;Property;protein function;Proteins;Publishing;Quarantine;Rattus;Recombinants;Reporting;Reproducibility;Reproduction;reproductive;Reproductive Biology;reproductive hormone;Research;Resources;response;Risk;Role;Science;skeletal;Societies;Sperm Count Procedure;Testis;The Jackson Laboratory;Therapeutic;Therapeutic Agents;Translating;United States National Institutes of Health;Universities;Validation;Vitamin K;Work

PROJECT_TITLE: Skeletal and non-skeletal roles for osteocalcin

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Older adults with opioid use disorder who receive care in opioid treatment programs are at heightened risk of being socially isolated, reporting loneliness, and experiencing everyday stigma. Measuring the lack of social connectedness and its relationship to intersectional stigma is important given their possible influence on treatment and health outcomes. The information learned from this project will inform providers and policymakers across the spectrum of clinical care on improving social connectedness among a growing yet often overlooked population made vulnerable.

PI_NAMEs: HAN, BENJAMIN HYUN (contact);INAGAKI, TRISTEN K.

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Acute;addiction;Address;Adult;adverse outcome;Age;Ageism;Anxiety;Area;behavioral health;Caring;Chronic Disease;clinical care;County;COVID-19 pandemic;Dementia;Drug usage;Elderly;Elements;experience;Feeling;Functional impairment;Future;Health;health care service utilization;Health Services;Healthcare;high risk;human old age (65+);Impaired cognition;implementation strategy;improved;interest;Intervention;Interview;Knowledge;Learning;Link;Literature;Loneliness;Measures;Mental Depression;Mental Health;Methadone;Methods;mortality risk;non-opioid analgesic;older adult;opioid treatment program;opioid use disorder;Outcome;Participant;participant enrollment;patient population;Patients;Pattern;Perception;Persons;physical conditioning;Policy Maker;poor health outcome;Population;Prevalence;Principal Investigator;protective factors;Provider;Public Health;Recovery;recruit;Reporting;Research;return to use;Risk;social;social contact;Social isolation;Social Network;social stigma;study population;substance use;Substance Use Disorder;Time;Treatment outcome

PROJECT_TITLE: Measuring Social Isolation, Loneliness, and Intersectional Stigma among Older Adults with Opioid Use Disorder