NIH_SPENDING_CATS: Genetics

ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Two aspects of the training program are relevant to public health. First, students are trained in basic science approaches that are fundamental to modern biomedical research. Second, all of the research projects have the potential to improve the understanding and treatment of human health problems, ranging from cancer to aging.

PI_NAMEs: JURA, NATALIA  (contact);TOCZYSKI, DAVID PAUL

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: Tetrad: Genetics, Cell Biology, Biochemistry and Molecular Biology Training Grant

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: DC

ARRA_FUNDED: N

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: BOYS TOWN

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: PROJECT NARRATIVE  There is a critical need for interdisciplinary research in the area of human communication and its disorders. The Boys Town National Research Hospital postdoctoral training program is designed to provide trainees with the expertise required to develop successful independent research programs through training in a large center comprising a highly collaborative and unique mix of behavioral and clinical translational research programs.

PI_NAMEs: CHATTERJEE, MONITA  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Communication;Disease;Human;Research

PROJECT_TITLE: RESEARCH IN HUMAN COMMUNICATION AND ITS DISORDERS


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dissemination and Implementation Research;Genetics;Human Genome;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The Transdisciplinary Conference for Future Leaders in Precision Public Health aims to develop and sustain a conference that provides a space for early career investigators who work in the field of cancer precision public health to come together to support capacity building for the field. This conference will annually convene 150 precision public health investigators and practitioners, from around the world to increase knowledge, to advance key research priorities for the field, and to establish an ongoing collaborative network to advance precision public health research in cancer. The long-term goal of this conference is to build capacity for and the impact of precision public health.

PI_NAMEs: ALLEN, CAITLIN GLOECKNER;ROBERTS, MEGAN C. (contact)

PROGRAM_OFFICER_NAME: ZAHIR, NASTARAN

PROJECT_TERMS: Applications Grants;Area;Australia;Behavior;Behavioral Sciences;biomedical informatics;Biometry;Cancer Control;cancer genomics;cancer prevention;Cardiovascular Diseases;career;career networking;Caring;Clinical;Collaborations;Development;Discipline;Early Diagnosis;Educational workshop;Environmental Health;Epidemiology;Evaluation;Event;Future;Genomics;Goals;Health;health equity;Health Policy;Health Services;Hybrids;implementation evaluation;implementation science;improved;Individual;infancy;insight;Institution;interactive feedback;interest;International;Knowledge;Life Style;Malignant Neoplasms;Manuscripts;Maps;Medical;meetings;Methods;North Carolina;nutrition;Outcome;Output;Participant;Patients;Persons;Pharmacogenomics;Population;population health;posters;precision medicine;Public Health;public health research;Publishing;Reporting;Research;Research Personnel;Research Priority;residence;Social Sciences;South Carolina;symposium;Technology;Time;Training;treatment strategy;Universities;virtual;webinar;Work;working group


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: CORAL GABLES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: OVERALL NARRATIVE The incidence of esophageal adenocarcinoma (EAC) is rising fast in the United States. EACs are characterized by resistance to therapy with poor clinical outcome. We plan to characterize mechanisms of disruption of transcription networks in esophageal tumorigenesis to identify novel preventive and therapeutic approaches.

PI_NAMEs: EL-RIFAI, WAEL  (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: 3-Dimensional;adduct;Affect;Animal Model;animal tissue;Barrett Esophagus;Barrett's Tumorigenesis;Bile Reflux;bile salts;Bioinformatics;Biology;Biometry;cancer cell;Cell Survival;Cells;Chronic;Clinical;Consultations;data exchange;data integration;Database Management Systems;Development;efficacy evaluation;ELF3 gene;Epidermal Growth Factor Receptor;Esophageal Adenocarcinoma;Esophagus;experimental study;FDA approved;Frequencies;Gastric Acid;Gastroesophageal reflux disease;Genetic;Genetic Transcription;Histopathology;human tissue;Immunohistochemistry;in vitro Model;in vivo;Incidence;Inflammatory Response;inhibitor;Injury;innovative technologies;Mediating;Medical;Metaplasia;Molecular;molecular pathology;mouse model;neoplastic cell;novel;novel strategies;novel therapeutic intervention;Oncogenic;Operative Surgical Procedures;Organoids;Outcome;Oxidation-Reduction;Oxidative Stress Induction;patient derived xenograft model;Patients;Pharmaceutical Preparations;Play;Population;pre-clinical;prevent;Preventive;Principal Investigator;Production;programs;Proteins;Proton Pump Inhibitors;PTGS2 gene;Reflux;Regulation;Research;response;Risk Factors;Role;Services;Signal Transduction;SOX4 gene;STAT3 gene;Stress;Survival Rate;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapy resistant;Tissue Sample;Tissues;tool;transcription factor;Transcriptional Activation;translational study;tumor progression;tumorigenesis;tumorigenic;United States;Western World;Work

PROJECT_TITLE: Disruption of Transcription Networks in Esophageal Adenocarcinoma Tumorigenesis


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Esophageal Cancer;Genetics;Rare Diseases

PHR: Project Narrative  The incidence of esophageal adenocarcinoma (EAC) is rising fast in the United States. EACs are characterized by resistance to therapy with poor clinical outcome. We plan to characterize novel molecular function(s) of APE1 in esophageal carcinogenesis, in order to identify its biological, diagnostic, prognostic, and possibly therapeutic significance.

PROJECT_TERMS: 3-Dimensional;adduct;Affinity;Barrett Esophagus;bile salts;Bioinformatics;Biological;Biology;Biometry;cancer cell;Cancer Model;carcinogenicity;Cell Survival;Cells;chemotherapeutic agent;chemotherapy;Chronic;Cisplatin;Clinical;clinically significant;Compensation;Complex;Cysteine;Development;Diagnostic;DNA Binding;DNA Binding Domain;DNA-(apurinic or apyrimidinic site) lyase;driving force;Environment;epigenetic regulation;Esophageal Adenocarcinoma;esophageal carcinogenesis;Esophagus;Event;evidence base;experience;Experimental Designs;Exposure to;fitness;functional outcomes;Gastroesophageal reflux disease;Genetic;Genetic Transcription;Human;human tissue;in vitro Model;Incidence;Inflammation;Malignant Neoplasms;Medical;Molecular;Molecular Biology;molecular pathology;mouse model;neoplastic cell;novel;novel therapeutic intervention;Oncogenic;Oncology;Organoids;Outcome;overexpression;Oxidation-Reduction;Oxidative Stress;Pathology;patient derived xenograft model;Patients;pharmacologic;Precancerous Conditions;prognostic;Property;Proteins;Reagent;Reflux;Regulation;Reproducibility;Resistance;response;Risk Factors;Role;Signal Transduction;SOX4 gene;Stress;Survival Rate;Therapeutic;Therapeutic Intervention;therapy resistant;Tissue Model;Tissue Sample;Tissues;tool;transcription factor;tumorigenesis;tumorigenic;United States;Western World;Work

PROJECT_TITLE: Elucidating Novel APE1 Redox-Dependent Functions in Esophageal Adenocarcinoma


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Esophageal Cancer;Prevention;Rare Diseases

PHR: NARRATIVE  Esophageal adenocarcinoma is a significant health problem in the U.S. due to its increasing incidence, poor survival rate, and limited treatment options. The proposed research will provide new insights into esophageal carcinogenesis and lay the groundwork for novel cancer chemopreventive treatments.

PI_NAMEs: ZAIKA, ALEXANDER I. (contact)

PROJECT_TERMS: adduct;Affect;Animal Model;Animals;bile salts;Biochemical;Biological Process;Biology;Cancerous;carcinogenicity;Cells;Chemopreventive Agent;Chronic;Clinical;cooperative study;Country;Data;Development;Digestive System Disorders;Disease;Duodenum;Environment;Esophageal Adenocarcinoma;esophageal carcinogenesis;Esophagus;Exposure to;Gastric Acid;Gastroesophageal reflux disease;Genetic;Genetic Transcription;Health;Human;human tissue;Incidence;Inflammation;Inflammatory Response;Injury;innovation;insight;JAK1 gene;Laboratories;Lesion;Link;Malignant Neoplasms;Metaplasia;Morbidity - disease rate;mortality;mouse model;novel;novel therapeutics;Oncogenic;Operative Surgical Procedures;Organoids;Patients;Precancerous Conditions;premalignant;prevent;Preventive;Preventive treatment;Process;Program Research Project Grants;Property;Protein Inhibition;Proteins;Proteomics;PTGS2 gene;Reflux;Regulation;Research;response;Risk Factors;Role;Signal Pathway;Signal Transduction;Signaling Protein;Solid Neoplasm;SOX4 gene;Specimen;STAT3 gene;Stat3 protein;Survival Rate;Testing;tissue injury;tool;tumor;tumorigenesis;tumorigenic

PROJECT_TITLE: Regulation of the JAK/STAT Signaling and Esophageal Tumorigenesis in Conditions of Esophageal Reflux Injury


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Esophageal Cancer;Genetics;Orphan Drug;Rare Diseases

PHR: Narrative The incidence of esophageal adenocarcinoma (EAC) has increased 600% in the last three decades, and treatment options are limited. This proposal will identify the mechanisms underlying the initiation and maintenance of EAC relevant to stem cell regulation. The knowledge gained will be used for comprehensively identifying new therapeutic targets and medications for treating the disease.

PI_NAMEs: QUE, JIANWEN  (contact)

PROJECT_TERMS: Abbreviations;Address;adduct;Adenocarcinoma;Adenocarcinoma Cell;advanced disease;Animal Model;Barrett Esophagus;Basal Cell;Bile Acids;bile salts;Biopsy;cancer cell;Cancer Cell Growth;cancer initiation;Cell Line;Cell Proliferation;Cell Survival;cell transformation;Cells;ChIP-seq;Collaborations;Data;design;Development;Diagnosis;Disease;Disease Progression;Distal;Down-Regulation;drug candidate;drug efficacy;Drug usage;effective therapy;ELF3 gene;endonuclease;Environment;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Esophageal Adenocarcinoma;Esophagus;Event;experimental study;FDA approved;Frequencies;gain of function;Gastroesophageal reflux disease;Genetic;Genetic Transcription;Growth;Health;Human;improved;In Vitro;in vivo;in vivo Model;Incidence;inhibitor;insight;Intestinal Metaplasia;knock-down;Knowledge;Libraries;loss of function;Maintenance;Malignant - descriptor;Malignant neoplasm of esophagus;Malignant Neoplasms;Mediating;Metaplasia;Metoprolol;Modeling;Molecular;mouse model;Mus;new therapeutic target;novel;Organoids;overexpression;Oxidation-Reduction;Oxidative Stress;patient derived xenograft model;Patients;Pharmaceutical Preparations;Prognosis;Program Research Project Grants;programs;Proliferating;Proteins;Reflux;Regulation;RNA Interference;RNA interference screen;Role;screening;Signal Transduction;Simple Columnar Epithelium;SOX4 gene;stem cells;Stomach;Stratified Squamous Epithelium;Survival Rate;synergism;targeted treatment;Testing;Therapeutic;Transcript;Transcription Coactivator;transcription factor;transcriptome sequencing;tumor;tumorigenesis;Work

PROJECT_TITLE: SOX4-Mediated Transcription Program in Esophageal Adenocarcinoma


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Chromosomes are packed into a cell’s nucleus in an orderly fashion, and early studies suggest that disorganized chromosomes can lead to health problems, for example neurological disease. This study will investigate what happens when the genes that orchestrate orderly chromosome packing are mutated. The results will improve the diagnosis of patients with mutations in these genes, lay the groundwork for targeted therapy of this class of neurogenetic disorder, and will generate fundamental knowledge about the spatial organization of the genome and the purpose it serves for reading the right genes in the right amount at the right time.

PI_NAMEs: BOONE, PHILIP MICHAEL (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: 3-Dimensional;Address;Boston;Bruck-de Lange syndrome;career;career development;Case Study;Cell Line;Cell Lineage;Cell model;Cell Nucleus;Cells;cellular engineering;chromosome conformation capture;Chromosome Segregation;Chromosome Structures;Chromosomes;Clinical;clinical phenotype;Clustered Regularly Interspaced Short Palindromic Repeats;cohesin;cohort;college;combinatorial;Communication;Complex;Congenital Abnormality;CRISPR-mediated transcriptional activation;Defect;design;Development Plans;Diagnosis;Disease;disease model;DNA;Doctor of Philosophy;dosage;Engineering;Enrollment;Environment;experience;experimental study;functional genomics;Gene Dosage;Gene Duplication;Gene Expression;gene function;Gene Mutation;Gene Structure;General Hospitals;Genes;genetic analysis;Genetic Counseling;Genetic Diseases;Genetic Transcription;Genome;Genomic medicine;Genomics;Goals;Grant;Health;Hi-C;Human;human disease;Human Genetics;improved;In Vitro;individual patient;Induced Neurons;induced pluripotent stem cell;insight;Institution;Knowledge;laboratory experience;Learning;loss of function;Massachusetts;Medical;Medical Genetics;Medicine;member;Mendelian disorder;Mentors;Mentorship;meter;Methods;mid-career faculty;Modeling;Molecular;Molecular Conformation;Molecular Genetics;mutant;Mutate;Mutation;nerve stem cell;Nervous System Disorder;neural;Neurodevelopmental Disorder;neurogenetics;Neurologic;Neurology;Neuronal Differentiation;Neurons;Organizational Change;Pathogenesis;Patient Care;patient derived induced pluripotent stem cells;Patients;Pediatric Hospitals;Pediatrics;Phenotype;Physicians;Population Genetics;post-doctoral training;programs;Proteins;Reading;Recording of previous events;Regulatory Element;Research;Residencies;responsible research conduct;Role;Scientist;skills;stoichiometry;targeted treatment;Therapeutic;three dimensional structure;Time;Training;transcriptome;transcriptome sequencing;transcriptomics;Variant;Work;Writing

PROJECT_TITLE: Defining the Disorders of Genome Organization

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_DEPT: NEUROLOGY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Frontotemporal dementia (FTD) is a leading cause of dementia and one of the most common causes of early- onset dementia. Diverse molecular pathologies cause FTD (collectively known as frontotemporal lobar degeneration [FTLD] pathology), which has complicated the development of positron emission tomography (PET) tracers for these diseases. This project will evaluate and validate new PET tracers, which could improve FTD/FTLD diagnosis and differential diagnosis and facilitate drug development for these diseases.

PI_NAMEs: SOLEIMANI-MEIGOONI, DAVID NIMA (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Acceleration;Advanced Development;Affinity;Aging;Alzheimer's Disease;Alzheimer's disease patient;Amyloid;analog;Area;Argyrophilic Grain Disease;Autopsy;Basal Ganglia;Behavioral;Binding;Biological Markers;Biometry;Brain;Brain Diseases;brain magnetic resonance imaging;C9ORF72;California;career;career development;Categories;Clinical;Clinical Data;clinical diagnosis;clinical diagnostics;Clinical Research;Clinical Trials;Cognitive;comparison control;corticobasal degeneration;corticobasal syndrome;Data;Data Collection;Dementia;Development;Diagnosis;Diagnostic;diagnostic criteria;Differential Diagnosis;Disease;Disease Progression;disorder control;drug development;Drug Kinetics;early onset;Environment;Evaluation;experience;Fluorine;fluorodeoxyglucose positron emission tomography;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Genetic;Globus Pallidus;Goals;Grant;Hippocampus;hyperphosphorylated tau;Immunoassay;Immunohistochemistry;improved;In Vitro;in vivo;in vivo imaging;Individual;Infrastructure;instructor;Integral Membrane Protein;K-Series Research Career Programs;Label;Lead;Learning;Ligand Binding;Ligands;Magnetic Resonance Imaging;Measures;medial temporal lobe;meetings;Memory;Mentors;Mentorship;Methods;mild cognitive impairment;Modeling;molecular pathology;Monitor;mutation carrier;Neocortex;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;neuroimaging marker;Neurologist;neuropathology;novel;Operations Research;Orphan Drugs;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Patient Recruitments;Patients;Pattern;pharmacokinetic model;Phenotype;Pick Disease of the Brain;Positron-Emission Tomography;precision medicine;preclinical development;Presynaptic Terminals;Primary Progressive Aphasia;programs;Progressive Supranuclear Palsy;Protein Isoforms;protein TDP-43;Proteins;putamen;Qualifying;radiotracer;Recombinants;recruit;Research;research clinical testing;Research Design;Research Ethics;Research Personnel;Resources;San Francisco;Scientist;Semantics;Sensitivity and Specificity;Site;skills;Standardization;Structure;Structure of subthalamic nucleus;Substantia nigra structure;Synapses;Synaptic Vesicles;Synaptophysin;Syndrome;tau aggregation;tau Proteins;Tauopathies;Technical Expertise;Techniques;Thick;Tracer;Training;Translations;treatment response;Universities;uptake;Validation;Variant

PROJECT_TITLE: Development of Emergent PET Tracers in Frontotemporal Lobar Degeneration

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Esophageal Cancer;Rare Diseases

PHR: NARRATIVE The Administrative Core is responsible for managing the P01 resources and facilitating communications between the P01 components, other collaborators, and with the NCI. This is accomplished through a series of oversight committees and scientific meetings.

PROJECT_TERMS: Academic Medical Centers;Accountability;Administrator;Annual Reports;Cancer Biology;Cancer Center;Collaborations;Communication;Communities;Comprehensive Cancer Center;Dedications;Diagnostic;Doctor of Philosophy;effectiveness evaluation;Electronic Mail;Ensure;Esophageal Adenocarcinoma;Evaluation;Evaluation Research;experience;Extramural Activities;Genetic Transcription;Individual;Information Technology;Infrastructure;Institution;Journals;Laboratory Research;Leadership;Malignant neoplasm of esophagus;Measures;medical schools;meetings;member;Monitor;Office of Administrative Management;operation;Operative Surgical Procedures;Organization administrative structures;organizational structure;Outcome;Patient advocacy;Performance;Principal Investigator;Procedures;Process;professor;Program Development;Program Research Project Grants;programs;Publications;Published Comment;Reporting;Research;Research Activity;research and development;research data dissemination;Research Personnel;Research Project Grants;Research Support;Resources;senior faculty;Series;Services;Site;social media;Structure;success;symposium;Telefacsimile;Therapeutic;translational scientist;Tumor Biology;tumorigenesis;Universities;Visit;web site;Work;Writing

PROJECT_TITLE: CORE A (Administrative Core)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Mental Health;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative: We carried out the largest prospective study of laser ablation and traditional open resection (OR) epilepsy surgery techniques using neuropsychological testing and neuroimaging completed at pre- and 1-year post- surgical time points (N=425+), and will now assess moderate term (5-10 year) outcome for all subjects with regards to seizure freedom, and cognitive and functional recovery (i.e., changes in ability to work, live independently). Preliminary data lead us to predict far better longitudinal cognitive and functional recovery for laser ablation patients, and has led us to question the validity of existing models of the brain regions involved in verbal memory and language. We will use advanced neuroimaging techniques to guide surgical practice (i.e., extent and location of ablation/resection) and outcome prediction at the level of the individual patient, while improving our knowledge of the neural circuits underlying cognition.

PI_NAMEs: DRANE, DANIEL L (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Ablation;Activities of Daily Living;Adoption;Adult;Affect;Amaze;Anatomy;Behavioral;Belief;Benchmarking;Brain region;Clinical;clinical translation;Cognition;Cognitive;cognitive function;cognitive recovery;cohort;Comparative Study;Complex;connectome;Data;Diffusion Magnetic Resonance Imaging;entorhinal cortex;Epilepsy;Excision;Exhibits;Face;follow-up;Freedom;functional improvement;Functional Magnetic Resonance Imaging;functional outcomes;Fusiform gyrus;Goals;Heterogeneity;Hippocampus;Human;improved;Individual;individual patient;Influentials;Knowledge;Language;Lasers;Lead;Learning;Left;Lesion;Location;longitudinal analysis;Maps;Measures;Medial;Memory;Methods;minimally invasive;Modeling;multidisciplinary;multimodal learning;Names;Nature;neural circuit;neuroimaging;Neuropsychological Tests;Neuropsychology;novel;object recognition;Operative Surgical Procedures;Outcome;outcome prediction;Patients;Postoperative Period;Procedures;prospective;Prospective Studies;rate of change;Recovery;Recovery of Function;Relative Risks;Rest;Retrieval;Role;Sampling;Seizures;Semantic memory;Semantics;Structure;Symptoms;Techniques;Temporal Lobe;Time;United States National Institutes of Health;ventral visual stream;verbal;Work

PROJECT_TITLE: Dissecting the Cognitive Roles of Hippocampus and Other Temporal Lobe Structures in Patients Undergoing Epilepsy Surgery

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Ocular and visual health are critical to independence and maintenance of quality of life. This grant seeks to train the next generation of vision scientists conducting both basic and clinically translational work to develop treatments for sight-threatening conditions. The interdisciplinary faculty from the vision science graduate program housed within the College of Optometry at The Ohio State University provide a diverse portfolio of research expertise to develop future leaders in vision research.

PI_NAMEs: ANDERSON, HEATHER ANNE (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Training Programs;vision science

PROJECT_TITLE: Vision Science Training Program


PHR: Narrative: The Molecular Pathology Core will oversee collection, storage, and organization of human and animal tissue specimens for P01 projects as needed. The Core will coordinate the processing of human and animal tissues through the Biospecimens Shared Resource and the Pathology Research Histology Lab. The Molecular Pathology Core will provide investigators with expert histopathologic, immunophenotypic, and quality control analysis of all processed human and animal tissue samples for this P01.

PI_NAMEs: MCDONALD, OLIVER GENE (contact)

PROJECT_TERMS: animal tissue;Animals;anti-cancer research;Barrett Esophagus;Basic Science;biobank;Biostatistics Core;Chemicals;Clinical;clinically relevant;Collaborations;Collection;Comprehensive Cancer Center;Consultations;cost effective;Data;Dedications;Diagnostic;Doctor of Philosophy;Dysplasia;Ensure;Esophageal Adenocarcinoma;Evaluation;experience;Experimental Pathology;Fee-for-Service Plans;gastrointestinal;Genetic Transcription;Histology;Human;human tissue;Immunophenotyping;In Situ;in vivo;Individual;Infrastructure;interest;Laboratories;Lesion;Measures;Microscopic;molecular pathology;Morphology;mouse model;Mus;neoplastic;Operative Surgical Procedures;Pathologist;Pathology;Patients;Process;protein expression;quality assurance;Quality Control;Research;Research Personnel;Resource Sharing;Resources;Sampling;Services;Site;Slide;Specimen;Staging;Stains;Structure;Supervision;System;Testing;Tissue Procurements;tissue resource;Tissue Sample;Tissues;tumorigenesis;Universities;Work

PROJECT_TITLE: CORE B (Molecular Pathology Core)


PHR: Narrative  The purpose of the Biostatistics and Bioinformatics Core (Core C) is to provide professional expertise in computing, bioinformatics, and biostatistics for all P01 projects, investigators, and participants.

PI_NAMEs: CHEN, XI STEVEN (contact)

PROJECT_TERMS: Academic Medical Centers;Animals;Applications Grants;Area;Back;Bioinformatics;Bioinformatics Shared Resource;Biology;Biometry;Clinical;cloud storage;Collaborations;Communication;Comprehensive Cancer Center;Data;Data Analyses;data exchange;data quality;Databases;design;Development;Ensure;Esophageal Adenocarcinoma;Evaluation;experience;Experimental Designs;experimental study;Faculty;Genetic Transcription;Genomics;Human Resources;Laboratories;laboratory experiment;Malignant Neoplasms;Manuscripts;member;Methods;Mission;molecular pathology;Participant;Population Intervention;power analysis;programs;Publications;quality assurance;Quality Control;Reporting;research and development;Research Design;Research Personnel;Research Project Grants;Sample Size;Sampling;Services;Specific qualifier value;Statistical Data Interpretation;Statistical Methods;Testing;tumorigenesis;Universities;Work;Writing

PROJECT_TITLE: CORE C (Biostatistics and Bioinformatics Core)


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_CITY: LOUISVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE Periodontitis is a prevalent oral disease in adults. This study seeks to elucidate the biological significance of cobalamin (Vitamin B12) utilization in the survival and pathogenesis of Porphyromonas gingivalis, a major contributing pathogen to periodontitis.

PI_NAMEs: GHODS, SHIRIN  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Adult;Adverse effects;Anaerobic Bacteria;Applications Grants;Bacteria;Biological;biological adaptation to stress;Biological Assay;Cells;Cobalamin;Cobalt;Data;differential expression;Disease;Disease Progression;Ensure;environmental stressor;Etiology;Exhibits;Fostering;Foundations;Gene Expression Profile;Gene Expression Regulation;Genes;Genomics;gingipain;Growth;Health;Homeostasis;Host Defense Mechanism;Human;Immune response;Individual;Infection;Inflammatory;insight;Iron;Laboratories;Mediating;Mediator;Metabolic;metabolic profile;metabolomics;microbial;microbiome;Modification;Molecular;Mouth Diseases;neutrophil;Nutritional;Outcome Study;oxidation;Oxidation-Reduction;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Peptide Hydrolases;Periodontal Diseases;Periodontal Pocket;Periodontitis;periodontopathogen;Play;Porphyromonas gingivalis;Proliferating;Reactive Oxygen Species;Research;Role;sensor;Stress;stressor;Therapeutic Intervention;Time;Tissues;Tooth structure;transcriptome sequencing;Up-Regulation;Validation;Virulence;Virulence Factors;virulence gene;Vitamin B 12;Whole Blood

PROJECT_TITLE: Cobalamin in Porphyromonas gingivalis Pathogenicity

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 YM (09)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative - A Global Syphilis Vaccine Targeting Outer Membrane Proteins of Treponema pallidum The scientific premise of this CRC proposal derives from three decades studying the composition and ultrastructure of the outer membrane of Treponema pallidum subsp. pallidum, the syphilis spirochete. The central hypothesis of the proposal is that T. pallidum’s repertoire of outer membrane proteins are the best targets for syphilis vaccine development and that vaccines based on this premise can be produced at the scale needed for a phase 1 clinical trial.

PI_NAMEs: MOODY, MICHAEL ANTHONY (contact);RADOLF, JUSTIN D

PROGRAM_OFFICER_NAME: HILTKE, THOMAS J

PROJECT_TERMS: adverse birth outcomes;Animal Model;Animals;Antibodies;Antigens;Architecture;Award;base;Bioinformatics;Biological Assay;biophysical techniques;Connecticut;Contracts;Coupled;Data;design;Development;Disease;Engineering;Ensure;Epitopes;Escherichia coli;experimental study;extracellular;Extracellular Protein;genomic data;Good Manufacturing Process;Grant;Growth;head-to-head comparison;Health;Human;Immune response;Immunity;Immunization;immunogenic;In Vitro;Individual;Investigation;Knowledge;Laboratories;Laboratory Research;lipid nanoparticle;manufacture;manufacturing organization;meetings;Membrane;Membrane Proteins;Messenger RNA;Methods;Modeling;Molecular;Molecular Conformation;Monoclonal Antibodies;Mus;neutralizing antibody;Order Spirochaetales;Oryctolagus cuniculus;Pennsylvania;Perinatal mortality demographics;Phase I Clinical Trials;phase I trial;physical property;pre-clinical;Process;Production;programs;Quality Control;Reagent;Reporting;Research;response;Rest;scaffold;success;Surface;Syphilis;syphilis vaccine;Testing;Toxicology;Treponema pallidum;Treponema pallidum subspecies pallidum;United States;vaccine development;vaccine platform;Vaccine Production;Vaccines;vaccinology;Variant;Vertical Disease Transmission;Virus-like particle;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 KAR-M (J1)]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: NARRATIVE We aim to create a special mouse strain that will help us understand the functions of immune cells called ILC3s, which are important for defending the body against microbes and in maintaining tissue health. By using a cutting- edge gene-editing technique called CRISPR, we will develop a mouse strain that produces a genome engineering protein, called Cre, only in mature ILC3s, allowing us to study unique ILC3 functions without interference from other similar immune cells. This breakthrough will open doors to explore the effects of ILC3s in various health and illness settings, such as infections, inflammatory bowel diseases, cancer, and autoimmunity.

PI_NAMEs: OLTZ, EUGENE M (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Ablation;Alleles;Antigen Receptors;arm;Autoimmune Diseases;Autoimmunity;Automobile Driving;Bacterial Artificial Chromosomes;Cell Compartmentation;Cell Physiology;cell type;Cells;chromosomal location;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Cre driver;cytokine;Elements;Embryo;Enhancers;Equilibrium;Exhibits;flexibility;functional plasticity;Future;gene-editing approach;Generations;Genes;Genetic Engineering;Genetic Transcription;Genome engineering;Goals;Health;Helper-Inducer T-Lymphocyte;Homeostasis;Host Defense;IL17 gene;Immune;immune function;Immune response;Immune System Diseases;in vivo;Infection;Infection Control;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Innate Immune Response;Innate Immune System;interleukin-22;interleukin-23;Internal Ribosome Entry Site;Kinetics;Knock-in;LoxP-flanked allele;Lymphoid;Lymphoid Cell;Malignant Neoplasms;Mediating;Memory;Microbe;Modeling;Monitor;Mouse Strains;Mucous Membrane;Mus;offspring;pathogen;Pathway interactions;Play;Population;Production;programs;Protein Engineering;Publishing;Reporter;Research;Resolution;response;Role;Signal Transduction;Specificity;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Tissues;transcription factor;Transgenes;tumorigenesis

PROJECT_TITLE: Generation of an ILC3-specific Cre driver in mice

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative  This project seeks to test the effectiveness and feasibility of delivering a brief digital intervention, designed to rehabilitate self-worth through classical conditioning exercises, as an adjunct to intravenous ketamine treatments delivered by embedded providers in real-world ketamine clinics. Ketamine, a fast-acting antidepressant, may rapidly prime the brain for helpful forms of learning, and we seek to deliver such learning efficiently, through portable, low-cost, digital techniques. This work could ultimately lead to the ability to treat depression more efficiently and effectively.

PI_NAMEs: PRICE, REBECCA  (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Acute;adaptive learning;Adoption;anti-depressive agents;antidepressant effect;arm;Association Learning;Atrophic;Behavior Therapy;blind;Brain;Characteristics;Clinic;Clinical;clinical translation;Cognition;Cognitive;cognitive training;Communities;cost;cost effective;Data;Data Collection;Depressed mood;depressed patient;depressive symptoms;design;Diagnostic;digital;digital intervention;digital treatment;Dose;Drug Controls;Educational Intervention;Effectiveness;effectiveness testing;effectiveness-implementation RCT;efficacy study;Enrollment;evidence base;Exercise;experience;Failure;flexibility;follow-up;Friends;Hippocampus;Home;Hour;Hybrids;implementation evaluation;Implicit Association Test;improved;indexing;Individual;information processing;Infusion procedures;Intervention;Interviewer;Intravenous;Intravenous Anesthetics;Ketamine;Learning;Maintenance;Measures;Medical;Mental Depression;Methods;Molecular;Molecular Profiling;Moods;Neurocognitive;Neuronal Plasticity;Neurons;novel;Outcome;outcome prediction;Outpatients;Patient Preferences;Patients;Pattern;performance based measurement;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacologic Actions;Phase;placebo group;portability;Prefrontal Cortex;profiles in patients;Proliferating;Property;Protocols documentation;Provider;Randomized;recruit;Research;Resistance;response;Risk Factors;Saline;Self Administration;Series;Severities;Site;Symptoms;synaptic depression;Techniques;Testing;Time;Training;Training Technics;Treatment Protocols;treatment-resistant depression;Uninsured Medical Expense;Work

PROJECT_TITLE: 1/2 A Brief Automated Neurocognitive Training to Enhance the Real-World Impact of Ketamine's Rapid Antidepressant Effect

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Immunotherapy;Patient Safety;Prevention

ORG_CITY: HERSHEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative Meta-analysis provides an invaluable tool to synthesize safety data from multiple clinical trials, offering a chance to comprehensively assess the risk of various adverse events including infrequent or even rare events. However, safety data pose unique statistical challenges, as adverse events vary in type and severity, are incompletely reported, and are influenced by a variety of clinical risk factors. To address a critical gap in analytical methods in this area, we propose to develop novel statistical strategies for combining safety data along with publicly available software implementations, providing useful tools to the scientific community to enable evidence-based evaluation of drug safety.

PI_NAMEs: PETERSON, CHRISTINE B;ZHOU, SHOUHAO  (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Acceleration;Address;Adopted;Adverse drug effect;Adverse event;adverse event risk;analytical method;Area;arm;Bayesian Method;Benchmarking;cancer immunotherapy;Cancer Patient;Clinical;Clinical Research;clinical risk;clinical trial analysis;Clinical Trials;Communities;Computer software;Data;data integration;design;Drug Evaluation;Drug toxicity;Event;evidence base;Evidence Based Medicine;Evidence based treatment;Exclusion Criteria;Foundations;Frequencies;Health;Health Policy;Healthcare;high risk;high risk population;Immunotherapy;impression;improved;Incidence;Individual;inhibitor;interest;Intervention;Knowledge;Literature;Medical;medication safety;Meta-Analysis;Methods;Modeling;Monitor;Nature;novel;novel strategies;Outcome;Patient Care;patient stratification;Performance;Pharmaceutical Preparations;Physicians;Policies;Population;Prevention;primary endpoint;Probability;prospective;Randomized, Controlled Trials;Recommendation;Reporting;Research;Risk;Risk Assessment;Risk Factors;Risk Reduction;risk stratification;Safety;safety outcomes;Sample Size;Sampling;Severities;simulation;Specific qualifier value;stem;Strategic Planning;Structure;Subgroup;systematic review;targeted therapy trials;Therapeutic Intervention;tool;Toxic effect;translational impact;Treatment Efficacy;Treatment-related toxicity;Trees;United States National Library of Medicine;Work

PROJECT_TITLE: Meta-analysis of Adverse Drug Effects in Clinical Trials

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Social Determinants of Health;Vaccine Related

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: This proposal requests funds to characterize the social and transmission networks of migrant workers in Greece to mitigate ongoing and future coronavirus epidemics among vulnerable populations in diverse contexts. We aim to better understand COVID-19 prevention, testing, treatment, vaccination, seroprevalence and immunogenicity in order to address facilitators and barriers to COVID-19 transmission mitigation. Critical to public health is improving COVID-19 prevention among these populations and their larger social networks.

PI_NAMEs: SCHNEIDER, JOHN  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Access to Information;Acquaintances;Address;Age;Award;Bangladeshi;Behavior;Biological;Categories;Communities;Computer Models;Contact Tracing;Coronavirus;Country;COVID-19;COVID-19 outbreak;COVID-19 prevention;COVID-19 risk;COVID-19 susceptibility;COVID-19 vaccination;Crowding;Data;Demography;density;Development;Diffuse;Diffusion;Disease Outbreaks;disease transmission;Documentation;Employment;Epidemic;Epidemiology;Essential worker;ethnic minority;Europe;European;Exclusion;experience;Family;Funding;Future;future epidemic;Gender;General Population;Geographic Distribution;Government;Greece;Greek;Health;health care availability;health plan;high risk;Hispanic;Household;Immigration;immunogenicity;improved;Income;Individual;innovation;Intervention;Latinx;Laws;Legal Status;Location;male;marginalization;Measures;Migrant;Migrant Workers;migration;Modeling;Names;Occupations;Outpatients;outreach program;pandemic disease;pandemic preparedness;Participant;Pathway Analysis;Patient Recruitments;Policies;Population;prevent;Prevention;preventive intervention;Preventive measure;Protocols documentation;Public Health;public health intervention;Public Sector;recruit;Regulation;Request for Proposals;Research Project Grants;Resource Sharing;Risk;Risk Factors;Sampling;SARS-CoV-2 infection;SARS-CoV-2 transmission;Seroprevalences;Site;social;social deprivation;Social Distance;Social Network;social stigma;Social support;South Asian;Stream;Structure;Surveys;System;systematic review;Target Populations;Testing;Time;transmission process;Vaccination;vaccine distribution;ventilation;virology;Vulnerable Populations;Work;working men;Workplace

PROJECT_TITLE: Covid-19 transmission, testing, and vaccination dynamics within migrant worker social networks

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Prevention;Primary Health Care;Sleep Research;Social Determinants of Health

PHR: PROJECT NARRATIVE Sleep disturbances in early adolescence are a major source of transdiagnostic mental health risk, including those associated with long-term morbidity and mortality including depression, substance use and suicide. The Pediatric Precision Sleep Network will identify clinically relevant sleep signatures that predispose youth to future mental health risks and develop predictive models that will inform screening and risk stratification based on these clinical signatures in primary care settings.

PI_NAMEs: JALBRZIKOWSKI, MARIA ;MCMAKIN, DANA L;SOEHNER, ADRIANE M. (contact);WALLACE, MEREDITH JOANNE LOTZ

PROGRAM_OFFICER_NAME: ZEHR, JULIA L

PROJECT_TERMS: actigraphy;Address;Adolescence;Age;age difference;aged;Algorithms;Behavioral;Boston;Cellular Phone;Characteristics;Childhood;Clinical;clinical decision-making;clinical predictors;clinically relevant;Communities;Computing Methodologies;Data;data analysis pipeline;Data Coordinating Center;data exchange;data integration;data management;data modalities;data quality;decision making algorithm;Development;Diagnosis;Diagnostic;diaries;Dimensions;disability;early adolescence;Early Diagnosis;Early Intervention;Effectiveness;Electronic Health Record;encephalography;Ethnic Origin;Exclusion;Exhibits;experience;Factor Analysis;follow-up;functional outcomes;Future;Geography;Goals;health data;health disparity;Heterogeneity;Home;improved;innovation;Intervention Trial;Investigational Therapies;Link;Measures;Medical;Mental Depression;Mental disorders;Mental Health;Methods;minority children;Modality;model building;Modeling;Modernization;Morbidity - disease rate;mortality;multimodal learning;multimodality;multiple data types;National Institute of Mental Health;Natural Language Processing;Observational Study;Outcome;Participant;Patient Recruitments;Patient Self-Report;pediatrician;periadolescent;Physiological;poor sleep;portability;predictive modeling;predictive signature;Predictive Value;Preventive care;Primary Care;primary care setting;Procedures;Process;prospective;psychiatric symptom;Puberty;Public Health;Quality Control;Race;racial minority;recruit;Research;Resources;Risk;Risk Factors;risk stratification;Sampling;screening;Secure;sex;Site;Sleep;Sleep Architecture;Sleep Disorders;Sleep disturbances;sleep health;sleep pattern;smartphone application;social;social culture;social health determinants;sociodemographics;Source;Standardization;Structure;substance use;Suicide;Surveys;Symptoms;Therapeutic Trials;therapy development;Time;tool;United States;Update;Visit;Work;Wrist;Youth

PROJECT_TITLE: The Pediatric Precision Sleep Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-S (01)]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE The Cryo-EM Facility at the University of Colorado Anschutz School of Medicine is an essential institutional and regional cryo-EM resource. Since it was established in 2016, the facility has supported cutting-edge NIH- funded research from groups across the Medical School and beyond. The centerpiece of the facility is a 200kV Thermo Fisher Talos Arctica transmission electron microscope. The current direct electron detector on the Arctica is 6 years old, starting to become unreliable, and no longer able to generate the best quality data in an efficient and user-friendly manner. Upgrading the imaging system in the Arctica represents the most economical and efficient way to bring the instrument back to the cutting-edge of cryo-EM technology. The imaging upgrade will allow the CU Anschutz Cryo-EM Facility to generate higher quality cryo-EM data in a considerably more efficient way, resulting in major cost benefits, easier data collection, and access to large- scale 3D imaging approaches like cryo-electron tomography. The imaging upgrade will ensure that the facility continues to provide state-of-the-art cryo-EM services for years to come.

PI_NAMEs: ASTURIAS, FRANCISCO J (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Area;Cancer Center;Clinical Sciences;Colorado;comparative;cost;Cryo-electron tomography;Cryoelectron Microscopy;Data;Data Collection;data quality;detector;Electron Microscope;Electron Microscopy Facility;Electrons;Equipment;Funding;future implementation;Grant;Image;imaging capabilities;imaging software;imaging system;Institution;instrument;medical schools;Optics;Peer Review;Phase;Play;Preparation;Publications;Research;Research Personnel;Research Support;Resolution;Resources;Role;Scientist;screening;Services;Source;Specimen;Stains;Structure;symposium;technology development;Three-Dimensional Imaging;Time;Translational Research;transmission process;United States National Institutes of Health;Universities

PROJECT_TITLE: Talos Arctica Electron Microscope Imaging System Upgrade

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-B (30)]


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetic Testing;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Nanotechnology;Prevention;Urologic Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Early detection of cancer is challenging due to poor adherence to screening schedules and poor sensitivity of existing methods. Using novel techniques for non-invasive detection of cancer, we will sequence epigenetic signatures found in the cell-free DNA found in the plasma fraction of blood. Using a combination of cell-free DNA from patients with a cancer diagnosis and pre-diagnostic plasma from the PLCO Screening Trial, we will determine the overall benefit of our new technology.

PI_NAMEs: JI, HANLEE P (contact);LAU, BILLY TSZ CHEONG

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: Adherence;Affect;Big Data Methods;biomarker identification;biomarker panel;biomarker signature;bisulfite;Blood;Blood Circulation;blood fractionation;Blood specimen;Cancer Biology;cancer biomarkers;Cancer Burden;Cancer Control;Cancer Detection;cancer diagnosis;Cancer Patient;cell free DNA;Cells;Characteristics;Classification;Clinical Trials;clinically relevant;cohort;colon cancer patients;Colorectal;Colorectal Cancer;colorectal cancer screening;Computing Methodologies;Cytosine;Data;Data Set;Detection;detection assay;Development;Diagnosis;Diagnostic;Diagnostic Procedure;Disease;Disseminated Malignant Neoplasm;DNA;DNA analysis;DNA Methylation;DNA sequencing;Early Diagnosis;Endoscopy;Epigenetic Process;Genomics;Growth;Immune;improved;innovation;interest;Lead;Lesion;liquid biopsy;Lung;machine learning algorithm;machine learning model;Malignant Neoplasms;Measures;Methods;Methylation;methylome;Modality;Modeling;Modification;molecular subtypes;Morphologic artifacts;mortality;nano;nanopore;neoplastic cell;new technology;next generation sequencing;Non-Invasive Cancer Detection;novel;novel diagnostics;novel strategies;Nucleosomes;Outcome;Ovarian;oxidative DNA damage;Patients;peripheral blood;Plasma;premalignant;Preparation;Primary Neoplasm;Process;Prostate;Sampling;Schedule;screening;Screening for cancer;Signal Transduction;single molecule;Site;Specificity;Stratification;success;targeted biomarker;Techniques;Technology;The Cancer Genome Atlas;Time;Training;treatment choice;trend;tumor;Tumor Burden;tumor DNA;Tumor stage;Tumor Subtype;unsupervised learning;Uracil;Validation;whole genome;Work;X-Ray Computed Tomography

PROJECT_TITLE: Single-molecule nanopore-based identification of methylome signatures in cfDNA for early colorectal cancer detection

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-D (J1)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: CINCINNATI

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: PROJECT NARATIVE The proposed research is relevant to public health because understanding the dynamics and mechanism of how regulatory T cells use dopamine to control their function is informative for understanding a variety of immune-related disorders and even neurodegeneration. Understanding how immune cell-derived dopamine changes with age and how these changes influence signaling at neuron-immune synapses is not well understood and this proposal seeks to address this fundamental gap. Thus, this proposal is relevant to part of the NIH’s mission that pertains to fostering fundamental creative discoveries and innovative research strategies as a basis for protecting and improving health.

PI_NAMEs: ROSS, ASHLEY E (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Address;Advanced Development;Age;age related changes;age related neurodegeneration;aged;Aging;Biology;Cell Communication;Cell Physiology;Cell secretion;Cells;Chemicals;cholinergic neuron;Coculture Techniques;Communication;Creativeness;Detection;Disease;Dopamine;Fostering;Goals;Health;IL2RA gene;Immune;Immune system;Immunity;immunological synapse;Immunology;Immunotherapy;improved;in vivo;innovation;insight;Knowledge;Ligation;Measures;Methods;Microfluidics;Mission;Molecular;Nerve Degeneration;neurochemistry;Neurodegenerative Disorders;Neuroimmune;neuroinflammation;Neurons;Neurosciences;neurotransmitter release;Neurotransmitters;novel strategies;Outcome;Periodicity;Physiological;Preparation;programs;Public Health;Published Comment;Regulatory T-Lymphocyte;Research;Rest;Role;Scanning;senescence;Signal Transduction;Synapses;System;T-Cell Receptor;T-Lymphocyte;targeted treatment;temporal measurement;Testing;Time;tool;United States National Institutes of Health;Work

PROJECT_TITLE: Untangling the role of dopamine release from Tregs: implications for neurodegeneration at the neuron-immune synapse

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative: Decreased coronary microvascular function is a recognized contributor to the development of chronic heart failure; mitochondrial DNA damage is thought to be a key component that uncouples cardiac demand from blood flow and Restoration of mitochondrial integrity is sufficient to restore physiological heart function. However, The effect of systemic anti-cancer therapy on human coronary microvascular function has not been evaluated and we hypothesize that anti-cancer therapy mitochondrial DNA damage promotes mitochondrial dysfunction (including elevated free radical production and release of mitochondrial DNA fragments) which augments therapy-induced microvascular dysfunction.  The overall goal of this application is to determine the role of telomerase, specifically in the mitochondria, in maintaining coronary vasodilation during external insult by chemotherapy.

PI_NAMEs: BEYER, ANDREAS M (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Acute;adverse outcome;Anthracycline;Biological Availability;Blood flow;Blood Vessels;breast cancer diagnosis;Breast Cancer survivor;Cancer Patient;Cancer Survivor;Cancer Survivorship;cancer therapy;Cancerous;Cardiac;Cardiac Myocytes;Cardiotoxicity;Cardiovascular Diseases;Cardiovascular Pathology;Cardiovascular system;Cause of Death;Cell Proliferation;Cell Survival;Cells;Cessation of life;chemotherapy;Clinical;Combination Drug Therapy;Congestive Heart Failure;Coronary;Coronary Arteriosclerosis;Coronary Vessels;Data;Development;disease model;DNA Damage;Doxorubicin;EFRAC;Endothelial Cells;endothelial dysfunction;Endothelium;ERBB2 gene;Event;expectation;experience;Exposure to;Free Radicals;Functional disorder;Goals;Heart;Heart Diseases;Heart failure;heart function;Human;Hypertension;improved;Inflammatory Response;Injury;Link;Longitudinal Studies;Malignant Breast Neoplasm;Mediating;Microcirculation;Microvascular Dysfunction;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Morbidity - disease rate;mortality;Muscle Cells;Myocardial;Myocardial dysfunction;Myocardium;Neoplasm Metastasis;Nitric Oxide;Nuclear;Oncology;Organ;Outcome;Pathology;Pathway interactions;Patients;Perfusion;Pharmaceutical Preparations;Physiological;Play;Predisposition;preservation;pressure;prevent;Production;Reactive Oxygen Species;repaired;Reporting;Research;restoration;Risk;Rodent;Rodent Model;Role;Signal Transduction;Survivors;Telomerase;TERT gene;Testing;TLR9 gene;Toxic effect;Trastuzumab;tumor;Tumor Burden;vascular endothelial dysfunction;Vascular Endothelium;Vasodilation;Woman;Workload

PROJECT_TITLE: Mechanism of Chemotherapy Induced Microvascular Dysfunction in Cancer Survivors

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Emergency Care;Health Services;Pediatric

ORG_CITY: TAMPA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: PROJECT NARRATIVE The proposed research addresses whether living near the coast during red tide events (caused by the algae K. brevis, which frequently grows out of control in the Gulf of Mexico and produces natural toxins) triggers emergency hospital visits among children. As the first ever epidemiologic study of residential brevetoxin exposures among children, this work will quantify short-term associations with emergency encounters overall and by discharge diagnoses. Such knowledge will be useful for characterizing the health effects of brevetoxin exposures among children, who are expected to be a sensitive population, and for improving public health guidance aimed at reducing the negative human health impacts of red tides.

PI_NAMEs: BULKA, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Accident and Emergency department;Address;Admission activity;Adult;aerosolized;Aerosols;Affect;aged;Air;Algae;Algal Blooms;Area;Biological;Bivalvia;Body Size;Body System;Breathing;brevetoxin;Categories;Characteristics;Child;Child Health;Childhood;Code;Communication;Consumption;contaminated seafood;cost;Cross-Over Studies;Data;design;Development;Diagnosis;Distress;Dose;Drug Metabolic Detoxication;Eating;Emergency Care;Emergency department visit;Emergency Medicine;Emergency Situation;Ensure;Environmental Epidemiology;Environmental Hazards;Environmental Protection;Environmental Wind;epidemiologic data;epidemiology study;Event;exposed human population;exposure pathway;exposure reduction interventions;exposure route;Exposure to;Eye;field study;Florida;Food;Fostering;Future;gastrointestinal;gastrointestinal symptom;Goals;Health;Human;Human Activities;improved;Individual;Inflammation;Ingestion;Inhalation;International Classification of Diseases;irritation;Knowledge;Link;Liver;Long-Term Effects;Maps;marine;Measures;Methods;Mexico;Monitor;Neurologic;Neurologic Symptoms;novel;Oceans;Organism;particle;pediatric emergency;Poison;Policies;Population;Population Study;Positioning Attribute;Predisposition;Prospective cohort;Public Health;public health intervention;rapid growth;Records;red tide;Research;Resources;respiratory;Respiratory Signs and Symptoms;Risk;Route;Safety;Science;Seawater;Shellfish;spatiotemporal;surveillance data;Time;Toxin;Trust;Universities;Visit;Water;Work

PROJECT_TITLE: Brevetoxins and Emergency Encounters among Children (BEECH)

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Parasitic worms (helminths) infect billions of people worldwide. Though generally asymptomatic, helminth co- infections may cause increased susceptibility to certain viral infections. This project uses mouse models to assess the fundamental biological and immunological mechanisms of this helminth-viral crosstalk.

PI_NAMEs: VON MOLTKE, JAKOB H. (contact)

PROGRAM_OFFICER_NAME: LINDE, AMBER SHRYER

PROJECT_TERMS: Acute;adaptive immune response;Adenoviruses;Anti-viral Response;Antigens;Bacterial Infections;Biological;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Characteristics;Chronic;Clinical;Clinical Data;co-infection;cytokine;Enteral;enteric adenovirus infection;enteric pathogen;enteric virus infection;Epithelial Cells;Feces;Future;Gastroenteritis;Gastrointestinal Diseases;Gastrointestinal tract structure;Health;helminth infection;Helminths;HIV;Hookworm Infections;Human;human model;IFNAR1 gene;IL4R gene;Immune;Immune response;Immunity;Immunologics;immunoregulation;Impairment;Infection;Inflammatory;Interferons;Interleukin-13;Interleukin-4;Interleukin-5;Intestines;intraepithelial;Knockout Mice;Measures;Mediating;microbiota;Modeling;mouse model;Mus;Mycobacterium tuberculosis;Nematospiroides dubius;Nippostrongylus;novel;Oral;Organoids;Outcome;pathogen;Persons;Population;Predisposition;Production;programs;recruit;Regulatory T-Lymphocyte;response;Role;sensor;Signal Transduction;Small Intestines;STAT1 gene;T cell response;Testing;Time;Tissues;Transcript;Viral;Viral Load result;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: An Intestinal Helminth Promotes Enteric Viral Infection Independent of Type 2 Immunity

STUDY_SECTION: IMII

STUDY_SECTION_NAME: Interspecies Microbial Interactions and Infectious Study Section[IMII]


ORG_CITY: LAWRENCE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE A fraction of the variation in lifespan is attributable to genetic differences among individuals, yet genomewide studies in humans have largely failed to identify specific genetic variants affecting longevity. Experimentally- flexible model systems offer a complementary avenue to study aging, but while work in fruit flies has been successful in addressing many questions about the control of lifespan, studies seeking to identify lifespan genes in flies have been underpowered. Here, we will deploy a novel strategy to compare cohorts of extremely old animals to control flies, enabling powerful detection and localization of the genetic factors that determine lifespan, and those that impact the response to a lifespan-extending intervention.

PI_NAMEs: LONG, ANTHONY DOUGLAS;MACDONALD, STUART JOHN (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Address;Affect;Age;age related;age-related disease;aged;Aging;aging mechanism;aging related;American;Animal Model;animal old age;Animal Testing;Biological Assay;Biological Models;Biology;Biology of Aging;causal variant;Chromosome Mapping;cohort;Complex;Control Animal;design;Detection;Diet;dietary;dietary restriction;Diploidy;Disease;disorder risk;Dissection;Drosophila genus;Drosophila melanogaster;Economic Factors;efficacy testing;Environment;Environmental Risk Factor;Exhibits;Experimental Genetics;experimental study;extend lifespan;Female;flexibility;fly;follow-up;Frequencies;Future;Gene Frequency;Genes;Genetic;genetic analysis;genetic architecture;genetic variant;Genetic Variation;Genome;Genome Scan;genome wide association study;genome-wide;Genomics;Genotype;Haplotypes;Harvest;Health;healthspan;Heritability;Human;human model;Inbred Strain;Inbreeding;Incidence;Individual;Individual Differences;innovation;insight;inter-individual variation;Intervention;Life;life span;Longevity;longevity gene;male;Maps;Mental Depression;Methodology;Methods;Molecular;Nature;novel;novel strategies;Pathway interactions;Pharmaceutical Preparations;Phenotype;Physiological;Plants;Play;Population;population based;Population Heterogeneity;Positioning Attribute;Process;Proxy;Quantitative Trait Loci;Random Allocation;Recombinants;Reproducibility;Resolution;Resources;response;Sampling;segregation;sex;simulation;Site;Sociology;success;System;Testing;tool;trait;treatment effect;Validation;Variant;Vial device;Work;Yeasts

PROJECT_TITLE: Evaluating a powerful genetic mapping framework to discover lifespan extension genes in Drosophila

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Project Narrative This project will develop a new simpler tool for conditional modification of proteins and RNA in mice called SpliceTag. Our work will allow researchers to extract proteins, organelles, and RNA from a single cell type in the context of complex tissues and organs that comprise multitudes of different cells. We expect that SpliceTag will not only forward our research in blinding disease, but its simplicity and utility will find a broad application.

PI_NAMEs: STOILOV, PETER  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Affect;Affinity;Alleles;Alternative Splicing;cell type;Cells;cis acting element;Cloning;CMV promoter;Complex;CRISPR/Cas technology;Darkness;Dependovirus;Disease;Epithelial Cells;Epithelium;Exons;Experimental Designs;experimental study;feasibility testing;Fluorescence Microscopy;Gene Targeting;Genes;Genetic;genetic manipulation;Genetic Recombination;Goals;Immunofluorescence Immunologic;Introns;Knock-in;Knock-out;knockout gene;Label;Light;LoxP-flanked allele;Measures;Messenger RNA;Mus;Neurons;Nonsense Codon;novel strategies;Organ;Organelles;Peptides;Phase;Photoreceptors;Post-Translational Protein Processing;preservation;Proteins;Randomized;recombinase;Regulation;repaired;Reporter;Research;Research Personnel;Retina;retinal neuron;Ribosomes;RNA;RNA Splicing;Satellite Viruses;Structure of retinal pigment epithelium;Terminator Codon;Testing;Tissues;tool;Transcript;transcriptome sequencing;Translations;Vision;Work

PROJECT_TITLE: Recombinase-free conditional knock-in through alternative splicing

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Immunization;Immunotherapy;Infectious Diseases;Infertility;Prevention;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: There is a clear need for a vaccine to protect against Chlamydia trachomatis, a sexually transmitted bacterium causing an ongoing epidemic associated with reproductive complications. The primary goal of this project is to perform studies in mice that will result in a Chlamydia vaccine candidate that is ready for early-phase human clinical trials.

PI_NAMEs: DARVILLE, TONI  (contact);ESSER-KAHN, AARON P;FAIRMAN, JEFF C

PROJECT_TERMS: Adjuvant;Agonist;Antibiotics;Antibodies;Antigen-Presenting Cells;Antigens;B-Lymphocytes;Bacteria;Biological Assay;CD4 Positive T Lymphocytes;Cells;Cellular Immunity;Cervical;Chlamydia;Chlamydia trachomatis;chlamydia vaccine;chronic pelvic pain;Clinical Trials;commercialization;Conjugate Vaccines;Contracts;cost;cytokine;Data;Development;Disease;Dose;Ectopic Pregnancy;efficacy evaluation;Epidemic;Female;Female infertility;female reproductive tract;female reproductive tract infection;Formulation;Generations;Goals;Good Manufacturing Process;Homing;Human;IL17 gene;Immunity;Immunization;Immunodominant Antigens;immunogenicity;imprint;improved;in vivo;Infection;Infertility;innovation;Interferon Type II;Interleukin-12;Lymphoid Tissue;male;Mammalian Oviducts;manufacturability;manufacturing organization;Mediating;Memory;Modeling;mucosal vaccination;Mucous Membrane;Mus;nanoemulsion;Nature;novel;Oils;pathogen;Pathology;Pelvic Inflammatory Disease;Peptide Hydrolases;Periodicity;Persons;Phase;Prevalence;Process;product development;Production;Qualifying;Recombinant Proteins;Regimen;reproductive;reproductive tract;response;Route;screening program;Sexual Transmission;Site;Squalene;Stimulator of Interferon Genes;synergism;T cell response;T-Lymphocyte;tissue resident memory T cell;Tissues;TLR7 gene;Toxic effect;Toxicology;transmission process;Treatment Cost;treatment program;United States;Vaccination;vaccine candidate;vaccine efficacy;vaccine evaluation;vaccine immunogenicity;vaccine trial;Vaccines;Water;Woman

PROJECT_TITLE: Development of a recombinant protein vaccine for Chlamydia trachomatis


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: Project narrative Mounting evidence from recent research, encompassing a variety of cancer types, points to links between biology of the disease and the patient's ancestral genetic background. It is the goal of this project to facilitate large-scale data-driven investigation in this important area via methods to learn a patient's genetic ancestry from tumor-derived molecular data, without the need to genotype the patient's cancer-free DNA or to know the patient's ethnic self-identification. Anticipated successful completion of the project will make hundreds of thousands of DNA and RNA profiles of tumors, from genomic data repositories, and millions of tumor specimens in biobanks, most with no matching normal genotype and no racial/ethnic annotation, available for ancestry- oriented cancer research.

PI_NAMEs: KRASNITZ, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: Admixture;Alleles;anti-cancer research;Area;ATAC-seq;biobank;Bioconductor;Biology;bisulfite;Cancer Diagnostics;cancer epidemiology;cancer genetics;cancer genome;cancer genomics;Cancer Patient;cancer type;Clinical;Collaborations;Communities;Community Outreach;computer framework;Computer software;computerized tools;Computing Methodologies;Copy Number Polymorphism;Correlative Study;Data;Data Analyses;Data Collection;data repository;Data Set;Diagnosis;digital repositories;Disease;DNA;DNA Methylation;DNA Sequence;Education and Outreach;Endowment;epidemiologic data;Ethnic Origin;Etiology;Exhibits;exome;Frequencies;Galaxy;Gene Mutation;Genes;Genetic;Genetic Transcription;Genome;genomic aberrations;genomic data;Genomic DNA;Genomic Instability;Genotype;genotyped patients;Goals;Haplotypes;improved;Incidence;Individual;innovation;Investigation;large scale data;Large-Scale Sequencing;Learning;Link;Loss of Heterozygosity;Malignant Neoplasms;Medical center;Metadata;Methodology;Methods;Modality;Molecular;Molecular Profiling;Mutation;open source;Operative Surgical Procedures;Outcome;patient population;Patients;Pattern;Performance;Phase;Phenotype;Population;Population Group;Preparation;Procedures;Productivity;profiles in patients;Race;Research;Resolution;Resources;RNA;RNA Sequences;Sequence Read Archive;Severities;software development;Software Framework;Software Tools;Source;Specificity;Specimen;synthetic data;Testing;The Cancer Genome Atlas;Tissue Banks;tool;Training;tumor;Tumor Tissue;Tumor-Derived;user-friendly;Variant;whole genome;Work;XCL1 gene

PROJECT_TITLE: Computational tools for accurate inference of genetic ancestry from cancer-derived molecular data

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-5 (J1)]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE - OVERALL The overarching scientific theme of the Wisconsin Alzheimer’s Disease Research center (ADRC) is preclinical, multimodal biomarkers of Alzheimer’s disease (AD) and their role in predicting transition from presymptomatic to clincial stages of the disease. There is convincing evidence that AD pathology starts several decades before the onset of symptoms, and discovery of biomarkers that represent asymptomatic stages of the disease will lead to early diagnosis and effective treatments and prevention strategies for the disease. Identifying asymptomatic at risk individuals during preclinical stages of AD will allow initiation of therapies that will either slow or, preferably stop the progression of the disease. Breakthrough research conducted at the Wisconsin ADRC has made seminal contributions to the field of AD research and has the potential to eventually find a cure for AD. This will have a great impact on patients and their families and will reduce the enormous societal costs and burden associated with this devastating disease.

PI_NAMEs: ASTHANA, SANJAY  (contact)

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: Adult;African American;Aging;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Autopsy;Biochemical;Bioinformatics;Biological;Biological Markers;biomarker discovery;Blood;Brain;brain tissue;caregiving;caregiving research;Caring;Characteristics;Clinical;Clinical Data;clinical diagnosis;clinical phenotype;clinical practice;Cognitive;cohort;Cohort Studies;Collaborations;collaborative environment;Communities;Community Outreach;comorbidity;Competence;Computerized Medical Record;computerized tools;Consultations;Data;Data Analyses;Data Collection;data management;Data Set;Data Storage and Retrieval;Dementia;dementia care;Development;Diagnosis;Dimensions;Disease;Disease Progression;DNA;Doctor of Philosophy;doctoral student;Early Diagnosis;Education and Outreach;education research;Educational Status;effective therapy;Ensure;Equity;Evaluation;Exercise;Faculty;Family;Funding;genetic risk factor;genome wide association study;Goals;Health;Health Professional;Heterogeneity;High School Student;Individual;Informatics;Infrastructure;innovation;International;Leadership;Life Cycle Stages;Link;Liquid substance;Measures;middle age;Mission;Modeling;Molecular;multidisciplinary;multimodality;Native Americans;Nature;Neurobiology;neuroimaging;neuropathology;Neurosciences;next generation sequencing;novel;Oneida;outreach;outreach program;Participant;participant enrollment;Pathologic;Pathology;Patient Care;Patients;Persons;Postdoctoral Fellow;pre-clinical;Prevention strategy;Process;programs;Race;recruit;Regulation;Research;Research Personnel;Resources;Risk;Role;Safety;Sampling;Scholars Program;Seminal;social;social culture;societal costs;socioeconomics;Standardization;Symptoms;synergism;Techniques;Technology;Training;translational study;treatment strategy;undergraduate student;Underrepresented Populations;vascular risk factor;volunteer;web services;Wisconsin;Work

PROJECT_TITLE: Wisconsin Alzheimer's Disease Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-G (J1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences

PROJECT_TERMS: Achievement;Address;Administrator;Advisory Committees;Advocacy;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Animal Welfare;Attention;Autopsy;Biological Markers;brain tissue;Characteristics;Clinical;Clinical Trials;Collaborations;Communication;Communities;comorbidity;cooperative study;Country;Data;data storage site;Dementia;Development;Disease;Education and Outreach;education research;Ensure;Equity;Exercise;Extramural Activities;Fostering;Funding;Future;Genetic;Goals;Health;healthy aging;high standard;Human Resources;human subject;improved;Individual;Informatics;Infrastructure;innovation;Institution;Leadership;Life Cycle Stages;Measures;mild cognitive impairment;Mission;Monitor;multidisciplinary;multimodality;neuroimaging;normal aging;novel;Participant;Pathology;Patient Care;Performance;Persons;Policies;pre-clinical;Productivity;programs;Race;recruit;Regulation;repository;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Review Committee;Role;rural area;socioeconomics;Source;success;Underrepresented Populations;Universities;Wisconsin

PROJECT_TITLE: Core A - Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

PI_NAMEs: CARLSSON, CYNTHIA M (contact)

PROJECT_TERMS: Adult;aging related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Biological;Biological Markers;Blood;Blood Tests;Blood Vessels;Brain;Caregivers;Caring;Cerebrospinal Fluid;Characteristics;Clinical;Clinical assessments;clinical center;Clinical Data;Clinical Research;Cognitive;cognitive testing;cohort;Collaborations;Collection;Communities;comorbidity;Consent;Coupled;Data;Data Collection;data management;data sharing;Dementia;dementia care;Development;Discipline;Disclosure;DNA;DNA Markers;Early Diagnosis;Early Intervention;Education;Education and Outreach;education research;Electronic Health Record;Enrollment;Ensure;Etiology;experience;Faculty;faculty mentor;Feedback;Fostering;functional outcomes;Funding;Goals;Grant;Health;human old age (65+);implementation facilitation;Individual;Lewy Bodies;Life Cycle Stages;lifestyle factors;limbic-predominant age-related TDP-43 encephalopathy;Link;Liquid substance;Magnetic Resonance Imaging;Measures;Medical;middle age;mild cognitive impairment;minority communities;Mission;multidisciplinary;multimodality;neighborhood disadvantage;neurobehavioral;Neurobehavioral Manifestations;neuroimaging;neuropathology;Neuropsychology;next generation;novel;outreach;Participant;Pathology;Patients;Persons;Pharmaceutical Preparations;Phenotype;Positron-Emission Tomography;pre-clinical;predictive marker;Process;Questionnaires;Race;recruit;repository;Research;research clinical testing;Research Personnel;Resources;Scientist;screening;Services;social health determinants;socioeconomics;Standardization;Statistical Models;Syndrome;tau Proteins;Test Result;tool;Training;Underrepresented Minority;Underrepresented Populations;Wisconsin;Work

PROJECT_TITLE: Core B - Clinical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: CHAPPELL, RICHARD J (contact)

PROJECT_TERMS: Achievement;Address;Alzheimer's Disease;Applications Grants;Area;Autopsy;Biological Markers;biomedical informatics;Brain;career development;Catalogs;Clinical Research;Clinical Trials;cognitive testing;Collaborations;Collection;Communities;Conceptions;Consultations;Data;Data Analyses;Data Analytics;Data Collection;data exchange;data integration;data management;Data Management Resources;Data Set;data sharing;Data Storage and Retrieval;data visualization;Databases;Dementia;design;Development;Ecosystem;Education;Education and Outreach;Educational Curriculum;Educational workshop;electronic data;Ensure;Faculty;falls;Fostering;Freezing;Goals;Grant;Health Disparities Research;health disparity;Housing;Image;improved;Individual;informatics tool;Infrastructure;innovation;Institution;International;interoperability;Journals;Link;Measures;Mediation;meetings;Methodology;Mission;Modeling;Monitor;multimodal data;next generation;novel;Participant;Pathway interactions;Patient Recruitments;Peer Review;Phase;Play;Preparation;Productivity;protective factors;Publications;recruit;Registries;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Resources;Risk Factors;Role;Schedule;Secure;Statistical Data Interpretation;Statistical Methods;Summary Reports;Support System;System;Tissues;Training;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Visit;webinar;Wisconsin

PROJECT_TITLE: Core C - Data Management and Statistical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: MONTINE, THOMAS J (contact)

PROJECT_TERMS: Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Archives;Autopsy;Behavioral;Biological Markers;Blood;blood product;Board Certification;Brain;Brain Pathology;Brain region;brain tissue;Caring;Cataloging;Catalogs;Cellular biology;Cerebrovascular Disorders;Cessation of life;Clinical;Cognitive;cohort;Collaborations;Collection;Communication;Consensus;Consent;Data;data management;Dementia;Diagnosis;Diagnostic;Disease;Disease Progression;Dissection;Elements;Enrollment;Ensure;Etiology;Evaluation;Examinations and Diagnoses;experience;Family;Freezing;Genetic;Goals;Guidelines;hippocampal sclerosis;Image;image guided;imaging biomarker;improved;Individual;Infrastructure;innovation;interest;International;Internet;Lewy Body Disease;Life;limbic-predominant age-related TDP-43 encephalopathy;Link;Liquid substance;Magnetic Resonance Imaging;Methods;Microscopic;mild cognitive impairment;Mission;Molecular Profiling;Monitor;Nerve Degeneration;neuroimaging;neuropathology;normal aging;novel marker;Onset of illness;Participant;Pathologic;Pathologist;Pathology;Patients;Persons;Phenotype;pre-clinical;preservation;Procedures;Process;programs;Protocols documentation;Provider;Qualifying;recruit;Registries;Research;Research Personnel;Resources;Role;Sampling;Services;software development;Specimen;symposium;Symptoms;Technology;Time;Tissue Banks;tissue fixing;Tissue Sample;Tissues;tool;Training;Translational Research;Update;whole slide imaging;Wisconsin;Work

PROJECT_TITLE: Core D - Neuropathology Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: EDWARDS, DOROTHY FARRAR (contact)

PROJECT_TERMS: Affect;Ally;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Ancillary Study;Awareness;Biological Markers;blood-based biomarker;Brain;brain health;Caring;Characteristics;Clinic;Clinical;Clinical Research;Clinical Trials;cohort;Collaborations;Collection;Communication;Communities;Community Healthcare;comorbidity;Consultations;data management;Dementia;design;Development;Diagnosis;Diagnostic;Disclosure;Education;education research;Educational Activities;Elderly;Ensure;Evaluation;Event;Evidence based program;Family;Feedback;General Population;Geriatrics;Gerontology;Goals;Health;Health Personnel;Health Professional;Health Services;improved;Individual;innovation;Knowledge;Life Cycle Stages;Link;Measures;Medical History;medical schools;Medicine;mild cognitive impairment;multimodality;neuropathology;outreach;Participant;participant enrollment;Pathology;Personal Satisfaction;Persons;Physicians;Plasma;podcast;Population;pre-clinical;preclinical study;prevent;primary care provider;Printed Media;Professional Education;programs;Provider;Public Health;Quality of Care;Race;recruit;Registries;Research;Research Personnel;Resolution;Resources;response;social media;Social Work;socioeconomics;State Government;study population;Training Programs;Translating;Translational Research;Underrepresented Populations;Universities;Wisconsin;Work

PROJECT_TITLE: Core E - Outreach, Recruitment and Engagement Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: JOHNSON, STERLING C (contact)

PROJECT_TERMS: Adopted;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-42;Atrophic;Biological Assay;Biological Markers;Blood;Blood flow;Brain;Cataloging;Cerebrovascular Disorders;Charge;Clinical;clinical diagnostics;Cognitive;Collaborations;Communities;Consensus;Data;Data Analyses;Data Pooling;density;Development;Diffusion;Disclosure;Glial Fibrillary Acidic Protein;Grouping;Health;Hemorrhage;Image;imaging biomarker;imaging modality;Impaired cognition;Impairment;in vivo;Infrastructure;Intake;Investigation;ischemic lesion;Joints;Learning;Length;Link;Liquid substance;Magnetic Resonance Imaging;Mass Spectrum Analysis;Measures;Methods;Modality;Molecular;Nerve Degeneration;Neurofibrillary Tangles;neurogranin;Neuronal Injury;neuronal pentraxin;neuropathology;new technology;novel;operation;Participant;participant enrollment;Pathology;Pattern;Performance;Perfusion;phosphoneuroprotein 14;Plasma;Positron-Emission Tomography;pre-clinical;Procedures;programs;Proteomics;Protocols documentation;Qualifying;Quality Control;radiotracer;Registries;Research;Research Personnel;resilience factor;Risk Factors;Sampling;Scanning;Science;Secure;Senile Plaques;Services;Standardization;Structure;symposium;Symptoms;Synapses;System;targeted biomarker;Techniques;Technology;Tissues;tool;Underrepresented Populations;web-based informatics;Wisconsin;Work

PROJECT_TITLE: Core G - Biomarker Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: BENDLIN, BARBARA BRIGITTA (contact)

PROJECT_TERMS: Address;Aging;Alzheimer's Disease;Basic Science;Behavioral;Biological;Biological Markers;Biology of Aging;career;career development;Caring;certificate program;Clinical;Clinical Research;Collaborations;community based research;comorbidity;Competence;Data Analytics;Degree program;Dementia;Development;Education;education evaluation;education research;Educational Activities;Educational Curriculum;Educational workshop;Effectiveness;effectiveness evaluation;effectiveness measure;efficacy evaluation;Ensure;experience;Exposure to;Faculty;Fellowship;Funding;Goals;Grant;Growth;Health;Individual;innovation;insight;Instruction;Interdisciplinary Study;Leadership;Learning;Life Cycle Stages;Liquid substance;Measurement;Mentors;Mentorship;Methods;Mission;multimodality;National Institute on Aging;neuroimaging;neuropathology;Neuropsychology;next generation;novel;Pathology;Pathway interactions;Persons;Postdoctoral Fellow;pre-doctoral;Productivity;programs;Publications;Records;recruit;Research;Research Personnel;Research Project Summaries;Research Training;scaffold;Scholars Program;Science;Scientist;success;Teacher Professional Development;Training;training opportunity;Training Programs;Translational Research;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities;Wisconsin;Work

PROJECT_TITLE: REC - Research Education Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: GLEASON, CAREY E (contact)

PROJECT_TERMS: African American;African American population;Alzheimer's Disease;Alzheimer's disease related dementia;American Indians;Amyloid;Biological;Biological Markers;Black American;Black race;Brain;brain health;Cerebrospinal Fluid;Characteristics;Clinical;clinical center;clinical practice;Clinical Trials;cohort;Collaborations;Collection;Communities;community advisory board;community engaged research;community engagement;comorbidity;Consultations;Data Collection;data management;Dementia;Education;Enrollment;Ensure;equity, diversity, and inclusion;Funding;Health;healthy aging;Indigenous;Individual;interest;Justice;Lead;Life Cycle Stages;Link;Liquid substance;Measures;military veteran;Minority Recruitment;multimodality;Native Americans;neuroimaging;neuropathology;novel;Oneida;outreach;Participant;participant retention;Pathology;personalized approach;Persons;Population Heterogeneity;Positioning Attribute;Positron-Emission Tomography;pre-clinical;Process;programs;Protocols documentation;Race;racial population;recruit;Registries;Research;Research Personnel;research study;Science;Services;socioeconomics;success;tau Proteins;Time;Underrepresented Populations;Veterans;Wisconsin;Work

PROJECT_TITLE: Core F - Inclusion of Underrepresented Groups Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences

PI_NAMEs: KIND, AMY J. (contact)

PROJECT_TERMS: Address;Advanced Development;advanced disease;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Area;Award;Biological Markers;Brain;Caregivers;Caring;Clinical;clinical care;Cognition;cohort;Collaborations;Communities;Consultations;Data;Dementia;dementia care;deprivation;Development;Diagnosis;Diagnostic;Disease;disease disparity;Disease Management;Disease Outcome;Electronic Health Record;Ensure;Funding;Geriatrics;Gerontology;Goals;Grant;health record;improved;improved outcome;indexing;Individual;Infrastructure;innovation;Investigation;Investments;Methodology;Modeling;multidisciplinary;National Institute on Aging;neuroimaging;Outcome;Patients;Persons;Plasma;Population;Preparation;Process;recruit;Registries;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;research study;Research Support;Resources;Rest;Services;social;social inclusion;Structure;symposium;System;Testing;therapy design;Training;United States;Wisconsin

PROJECT_TITLE: Core H - Care Research Core


PHR: Project Narrative Enteric infections by helminths that trigger type-2 immune mediated intestinal inflammation remain a significant global health problem. In this study we generate new tools to investigate epithelial cell-intrinsic host responses to helminth-induced mucosal type-2 immunity. These findings may provide rational approaches to modulate mucosal type-2 inflammation to enteric parasitic infections in humans.

PI_NAMEs: HINTERLEITNER, REINHARD  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acute;Address;Alleles;Anemia;Antigen Presentation;Antigen-Presenting Cells;Award;B-Lymphocytes;Back;Binding;C-terminal;Caspase;Cathepsins;Cell Death;Cells;chronic infection;Complex;conditional knockout;Containment;CRISPR/Cas technology;cytokine;Data;defense response;Dendritic Cells;Disease;effective therapy;Enteral;enteric infection;eosinophil;Epithelial Cells;Epithelium;experimental study;Frequencies;Future;gastrointestinal;gastrointestinal epithelium;Gene Cluster;global health;Goals;Goblet Cells;gut inflammation;helminth infection;Helminths;Histocompatibility Antigens Class II;Human;Hyperplasia;Immune;Immune response;Immunity;Impairment;Infection;Inflammation;inhibitor;Interleukin-13;Interleukins;intestinal epithelium;Intestinal parasite;Intestines;Knockout Mice;Laboratories;LoxP-flanked allele;Lymphoid Cell;Macrophage;Malnutrition;Mediating;Membrane Lipids;mesenteric lymph node;Modeling;Molecular;Morbidity - disease rate;mouse model;Mouse Strains;Mucous body substance;Mucous Membrane;Mus;Mutagenesis;N-terminal;Nematospiroides dubius;Nippostrongylus;novel;Organoids;Parasites;Parasitic infection;Peptide Hydrolases;Process;Production;protein expression;Proteins;Proteolysis;recruit;Regulation;Reporting;Research;response;Role;Signal Transduction;Small Intestines;Study models;T-Lymphocyte;Tamoxifen;Testing;tissue injury;Tissues;tool;Trichomonadida

PROJECT_TITLE: Novel mouse model for studying gut epithelial-cell intrinsic responses to helminth infections

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Patient Safety;Prevention

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE This Northwell Roybal Coordinating Center to Accelerate Translational Aging Research (RCC) intends to provide strategic leadership, efficient coordination, effective training, and proactive dissemination for the Edward R. Roybal Centers. All our activities will be focused on reinforcing the goals of the NIH Stage Model and promoting trans-Roybal collaborations.

PI_NAMEs: DAVIDSON, KARINA W. (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Acceleration;Achievement;Address;Aging;Agreement;Alzheimer disease prevention;Alzheimer's disease related dementia;Award;behavior change;Behavior Therapy;Behavioral Mechanisms;Behavioral Model;Behavioral Research;Caregiver support;Center for Translational Science Activities;central database;Clinical;clinical center;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;cognitive function;Collaborations;Common Data Element;Communication;Communities;Conduct Clinical Trials;Consensus;Consultations;Contracts;Data Collection;Data Management Resources;dementia care;design;Ensure;Evaluation;Event;forging;Fostering;Frequencies;Funding;Goals;Grant;healthy aging;impression;Infrastructure;innovation;Intervention;Joints;Lead;Leadership;Link;Mainstreaming;Measures;meetings;member;Methods;Modeling;Monitor;National Institute on Aging;nonalzheimer dementia;Operations Research;Outcome;patient safety;Peer Review;Productivity;Program Evaluation;programs;Publications;recruit;Research;research and development;Research Infrastructure;Research Priority;Research Support;Resources;Scientific Advances and Accomplishments;Scientist;secondary outcome;Site;social interventions;social media;success;System;Testing;theories;therapy development;Thinking;Training;Training Activity;Training and Education;training opportunity;Translational Research;U-Series Cooperative Agreements;United States National Institutes of Health;virtual;Visit;web site

PROJECT_TITLE: Roybal Resource and Coordinating Center to Accelerate Translational Aging Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-4 (J3)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Hematology;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: Project Narrative T-cell-based immunotherapies are providing new opportunities for personalized treatment of different types of cancer, but computational methods supporting these efforts are still missing key structural information. Our research aims at bridging this gap through the development of a new computational environment (HLA-Arena 2.0), which integrates new structural bioinformatics methods with existing ITCR resources. This will enable (i) structure-guided discovery of tumor-associated antigens, (ii) identiﬁcation of safer therapeutic T-cells for cancer immunotherapy, and (iii) the implementation of the ﬁrst database for T-cell off-target toxicity risk assessment.

PI_NAMEs: ANTUNES, DINLER  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Alleles;American Cancer Society;antigen binding;Antigen Receptors;Architecture;Atlases;Base Sequence;Benchmarking;Bioinformatics;Cancer Center;cancer immunotherapy;cancer therapy;cancer type;Cells;Cellular Immunity;Cellular immunotherapy;Cessation of life;Clone Cells;Collaborations;Communities;Complement;Complex;Computer Assisted;Computing Methodologies;cost;cross reactivity;Cytotoxic T-Lymphocytes;Dangerousness;Data;Data Set;Databases;Dependence;design;Development;Diagnosis;Environment;Evaluation;Fostering;Funding;Future;Goals;Growth;guided inquiry;Healthcare;Hematopoietic Neoplasms;high throughput screening;HLA Antigens;Immune response;immunogenic;immunogenicity;Immunotherapy;Impairment;improved;leukemia;Lymphocyte;Machine Learning;machine learning method;Malignant Neoplasms;Melanoma;melanoma-associated antigen;Methods;Mission;Modality;Modeling;Multiomic Data;Mutation;neoantigens;neoplastic cell;Outcome;Patients;Peptides;personalized cancer therapy;personalized medicine;Persons;Population;prevent;Proteomics;Reaction;receptor;Reporting;Research;Research Personnel;Resources;Risk Assessment;Running;Services;Solid Neoplasm;Structural Models;Structure;success;Surface;T cell therapy;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Techniques;Testing;Tissues;tool;Toxic effect;transcriptomics;treatment response;tumor;Tumor Antigens;tumor-immune system interactions;United States;Update;user-friendly;Vaccines;virtual screening;Work

PROJECT_TITLE: Structure-guided cancer immunotherapy design with HLA-Arena and CrossDome


ADMINISTERING_IC: DK

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Inflammatory Bowel Disease;Liver Disease;Microbiome;Nutrition;Obesity

PHR: Project Narrative The microbiome induces intestinal permeability and inflammation in metabolic syndrome. Identifying gut bacterial metabolites that damage intestinal integrity will illuminate how the microbiome affects host health. This will further allow development of therapeutics to alleviate microbiome-mediated disruption of intestinal homeostasis.

PI_NAMEs: CHAUDHARI, SNEHAL N. (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: absorption;Acute;Affect;Attention;Automobile Driving;Bacteria;bariatric surgery;Bile Acids;Bile fluid;bile salts;Binding Sites;Biochemical;Bioinformatics;Biological Assay;Biopsy;Carbon;Cells;choline deficient diet;Chronic;Cirrhosis;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Colon;comorbidity;Country;Coupled;Data;Development;dietary;Disease;disease prognosis;Epithelial Cells;Fatty Liver;Feces;folate-binding protein;Folic Acid;Folic acid fortification;gastrointestinal epithelium;General Hospitals;Genetic;Genetic Transcription;Germ-Free;Goals;Growth;gut bacteria;gut inflammation;Health;high throughput screening;Homeostasis;Human;Hydrolase;ileum;In Vitro;in vivo evaluation;Incubated;Individual;Induction of Apoptosis;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inflammatory modulation;inhibitor;Intestinal Absorption;Intestinal Content;intestinal epithelium;intestinal homeostasis;Intestinal permeability;Intestines;Libraries;Link;Liver;Liver Cirrhosis;Liver diseases;Macrophage;MAP Kinase Gene;Massachusetts;Measures;Mediating;medical schools;metabolic engineering;Metabolic syndrome;Metabolism;metabolomics;Metagenomics;microbial;microbiome;microbiome research;microbiome therapeutics;Mitochondria;Mitogen-Activated Protein Kinases;Morphology;Mus;nonalcoholic steatohepatitis;novel;Nutrient;Obesity;Pathogenesis;Pathway interactions;Patients;Phase;Phase Transition;Phenotype;Pilot Projects;Policies;Portal vein structure;prevent;Production;Prognosis;Proteins;Public Health;Rattus;Receptor Activation;Receptor Signaling;Research;Rodent;Rodent Model;Role;Sampling;screening;Severities;Signal Pathway;Signal Transduction;small molecule;stool sample;Targeted Research;Techniques;Testing;Therapeutic;therapeutic development;Tight Junctions;transcription factor;Up-Regulation;Work

PROJECT_TITLE: Elucidating the role of the microbiome in inducing gut permeability and inflammation

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]