NIH_SPENDING_CATS: Bioengineering;Clinical Research;Contraception/Reproduction;Data Science;Infertility;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE Assisted Reproductive Technology (ART) is a widespread treatment for infertility, over 300,000 treatment cycles were performed in the US in 2018, but success rates remain low. In this project, we will develop novel machine learning algorithms and a clinical decision support system to assist embryologists in embryo selection. Our tools will also enable embryologists and biologists to obtain new information on the earliest stages of human embryo development, which will advance the fundamental science of human biology and lead to further improvements in ART practice.

PI_NAMEs: BEN YOSEF, DALIT ;NEEDLEMAN, DANIEL ;PFISTER, HANSPETER  (contact);RACOWSKY, CATHERINE

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Adopted;Age;analytical tool;Assisted Reproductive Technology;Back;blastocyst;Cell Lineage;Classification;Clinic;Clinical;Clinical Data;Clinical Decision Support Systems;clinical decision-making;clinical practice;Clinical Treatment;cloud based;Cloud Service;cohort;Communities;Complex;Computer Models;computer scientist;Computer Vision Systems;convolutional neural network;Couples;Data;Data Analyses;data cleaning;data curation;data imputation;data management;Data Set;Data Storage and Retrieval;data visualization;Databases;Decision Making;deep learning;deep learning model;Detection;Development;Discipline;E-learning;Electronic Health Record;Embryo;embryo cell;embryo monitoring;Embryo Transfer;Embryonic Development;feature extraction;Fostering;Goals;Human;Human Biology;human embryonic development;human-in-the-loop;Image;Image Analysis;implantation;improved;In Vitro;Infertility;infertility treatment;insight;interactive visualization;Judgment;Knowledge;Label;large scale data;Machine Learning;machine learning algorithm;machine learning model;Manuals;Medical;Medical Care Costs;Methods;microscopic imaging;model design;Modeling;Morbidity - disease rate;Morphology;Mothers;multi-task learning;multimodality;Multiple Pregnancy;novel;Obesity;operation;Patients;Pattern;Physiological;Pre-implantation Embryo Development;pre-trained transformer;predictive modeling;predictive tools;Pregnancy;Pregnancy Rate;Privacy;Probability;Research;Science;Secure;Security;success;supervised learning;Text;tool;Trees;United States;unsupervised learning;Uterus;Visual;Visualization;Visualization software;zygote

PROJECT_TITLE: Enhancing Assisted Reproductive Technologies with Deep Learning and Data Visualization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-E(09)]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: DAVIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE This project studies how cognitive and functional reserve may reduce the clinical consequences of brain changes due to Alzheimer's disease (AD), cerebrovascular disease, and associated disorders. The public health goals of this project are to identify behavioral and lifestyle factors across the life span that promote reserve and protect people against the effects of AD and related diseases. Racial/ethnic minority groups may bare a disproportion burden of these diseases, and understanding factors that promote cognitive health in these groups is a national priority.

PI_NAMEs: FLETCHER, EVAN ;TOMASZEWSKI-FARIAS, SARAH E (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Accounting;Address;Affect;Aging;aging brain;aging related disease;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;Amyloid deposition;Asian population;Behavioral;Black Populations;Blood Vessels;Brain;brain based;brain behavior;Brain Pathology;Buffers;burden of illness;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular Trauma;Clinical;Cognition;Cognitive;cognitive function;cognitive reserve;cohort;critical period;Data;Dementia;demographics;Diagnosis;disability;Disease;Disparity;ethnic difference;ethnic disparity;ethnic diversity;ethnic minority population;Ethnic Origin;Ethnic Population;functional decline;functional outcomes;Goals;Grant;Health;health goals;Health Policy;healthy aging;Image;imaging approach;imaging modality;Impaired cognition;improved;Individual;innovation;Intervention;Knowledge;Label;late life;Latino Population;Life Cycle Stages;life span;Life Style;lifestyle factors;Longitudinal cohort;Magnetic Resonance Imaging;Measures;Medical;Methods;middle age;Modeling;modifiable lifestyle factors;multi-racial;multidisciplinary;Nerve Degeneration;neuroimaging;novel;older adult;Outcome;Personality;Persons;Population;Population Heterogeneity;Positioning Attribute;Positron-Emission Tomography;prevent;promote resilience;promoter;prospective;protective factors;psychosocial;Public Health;Race;racial difference;racial disparity;racial diversity;racial minority population;racial population;Research;Residual state;resilience;resilience factor;Resources;Risk;Risk Factors;Risk Reduction;Sampling;Severity of illness;social;Stress;Techniques;Testing;theories;Translating;β-amyloid burden

PROJECT_TITLE: Brain pathologies, reserve and cognition in aging and dementia

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: There is an urgent need to develop new therapies against KRAS-mutant lung cancer (KMLC) based on a better understanding of how KMLC cells maintain their survival and gain metastatic capacity. On the basis of the preliminary results presented here, we postulate that 2 types of collagen modifications by lysyl hydroxylase 2, an enzyme that is highly expressed in KMLC cells, drive tumor progression and metastasis. If proven true, these findings would advance our understanding of the mechanisms of KMLC progression and would provide a rationale to develop and test the efficacy of selective antagonists of lysyl hydroxylase 2 in KMLC patients.

PI_NAMEs: KURIE, JONATHAN M (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine;Acidic Amino Acids;Active Sites;Address;Affect;Affinity;Aldehydes;Alternative Splicing;antagonist;Arginine;Basic Amino Acids;Binding;Biological Assay;cancer cell;Cancer Model;Cancer Patient;cell behavior;Cells;Coculture Techniques;cohort;Collagen;Collagen Fibril;Collagen Receptors;crosslink;differential expression;efficacy testing;Electrostatics;Enzymes;Exons;Family member;Fibroblasts;Future;Glucose;Glucosyltransferase;glycosylated collagen;glycosyltransferase;high throughput screening;Hydroxylation;Hydroxylysine;Immune;Immunity;Immunocompetent;Immunosuppression;insight;Invaded;Knowledge;KRAS2 gene;lung cancer cell;Lysine;Malignant neoplasm of lung;Malignant Neoplasms;mechanical force;Mediating;migration;Modification;Mus;mutant;Myeloid Cells;Natural Killer Cells;Neoplasm Metastasis;novel therapeutics;Population;Production;Property;Protein Isoforms;Receptor Activation;Reporting;Rest;RNA Splicing;Source;Specific qualifier value;Structure;Structure-Activity Relationship;T-Lymphocyte;Testing;The Cancer Genome Atlas;tool;tumor;tumor progression;tumor-immune system interactions

PROJECT_TITLE: Elucidating pro-metastatic collagen modifying activities of lysyl hydroxylase 2

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Vital discoveries in recent years uncovered that lncRNAs play fundamental roles in cell processes and complex diseases. However, the molecular mechanisms by which they function are mostly unknown. This proposal focuses on understanding the precise mechanisms of how lncRNAs activate transcription and determining their structure-function relationships to establish them as therapeutic targets eventually.

PI_NAMEs: SOMAROWTHU, SRINIVAS  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: 3-Dimensional;Adopted;Affinity;Binding Sites;Biochemical;Biological Assay;Biological Models;cell motility;Cell Physiology;Cell Proliferation;Cells;Chemicals;Chromatin;chromatin remodeling;Complex;CRISPR/Cas technology;crosslink;Cryoelectron Microscopy;deletion analysis;Development;Disease;Disease Progression;DNA;Down-Regulation;Elements;Epigenetic Process;experimental study;Family;Gene Activation;Gene Expression Regulation;Gene Silencing;Genes;genetic regulatory protein;Genetic Transcription;Goals;Histones;Human;Immunoprecipitation;insight;Investigation;knock-down;Knowledge;Literature;Malignant Neoplasms;mammalian genome;Mammals;Maps;Micrococcal Nuclease;model building;Molecular;Mutate;novel;Nucleosomes;Nucleotides;particle;Plants;Play;Polycomb;potential biomarker;Process;promoter;Promoter Regions;Proteins;recruit;Reporting;Research;Resolution;RNA;Roentgen Rays;Role;scaffold;Site;Spectrometry;Structure;Structure-Activity Relationship;Sucrose;Technology;Testing;therapeutic target;three dimensional structure;Transcript;Transcription Coactivator;transcription factor;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;Untranslated RNA;Visualization;WNT Signaling Pathway

PROJECT_TITLE: Structural and Functional Studies of lncRNAs in Gene Activation

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Crohn's Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Pediatric

ORG_CITY: HARTFORD

ORG_NAME: CONNECTICUT CHILDREN'S MEDICAL CENTER

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed inception cohort study CAMEO will be unique in providing a robust, novel platform to study clinical and biological factors that contribute to bowel healing in pediatric Crohn's disease that can then be immediately translated into clinical practice, as well as guiding future therapies targeting the host immune responses and microbiota in patients unlikely to achieve healing with current approaches. Achieving higher rates of bowel healing will improve quality of life, mitigate need for surgery and hospitalizations, and potentially reduce long term healthcare expenditures.

PI_NAMEs: DENSON, LEE ARMISTEAD;HYAMS, JEFFREY SAMUEL (contact);KUGATHASAN, SUBRA

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Algorithms;Ancillary Study;Anti-Tumor Necrosis Factor Therapy;antimicrobial;biobank;Biological;Biological Factors;Budgets;Characteristics;Child;Childhood;Clinical;clinical practice;clinical remission;clinical research site;Clinical Treatment;Clinical/Radiologic;Cohort Studies;Colon;Colonoscopy;Crohn's disease;Data;Data Management Resources;Data Set;Development;Diagnosis;Disease;Disease remission;Dose;Drug Exposure;Drug Monitoring;Erythrocyte Sedimentation Rate;Exhibits;experience;Fibroblasts;Future;Gene Expression;Gene Expression Profile;genetic signature;Genetic Transcription;Genomics;Genotype;genotyped patients;Goals;healing;Health Expenditures;Hospitalization;hospitalization rates;Image;image archival system;Immune response;improved;Inflammatory;infliximab;insight;Institutional Review Boards;Intestines;Logistic Regressions;Macrophage;Magnetic Resonance;Manuals;Measures;Microbe;microbial;microbial community;microbial genomics;Microbial Taxonomy;microbiota;Modeling;Mucous Membrane;Multiomic Data;Neoadjuvant Therapy;Newly Diagnosed;novel;Nutritional status;operation;Operative Surgical Procedures;Outcome;Pathogenesis;Patients;Pediatric Crohn's disease;Pharmaceutical Preparations;Predictive Factor;predictive modeling;primary endpoint;Probability;Procedures;Process;Prospective, cohort study;Protocols documentation;Quality of life;Radiology Specialty;Reading;Refractory;Regimen;Reporting;response;Risk;secondary endpoint;Serology;seropositive;Services;Severities;Specific qualifier value;targeted treatment;Testing;Therapeutic;TNF gene;transcriptome;transcriptomics;Translating;Validation

PROJECT_TITLE: Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed with Crohn's Disease


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: FAIRFAX

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGE MASON UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE The proposed research is relevant for public health, because the expected results of the proposed experiments will inform models for cortical coding of location and movement speed supporting memory-guided navigation. Innovative experiments will investigate the contribution of different sensory modalities to the encoding of a cognitive map and modulation of encoding and retrieval by the neuromodulator acetylcholine. The project is relevant to NIMH's mission, because the expected results will contribute to our mechanistic understanding of the cognitive processes underlying the coding of location for memory function and the role of cholinergic modulation underlying these processes, which are altered in psychiatric disorders such as schizophrenia and major depressive disorder.

PI_NAMEs: DANNENBERG, HOLGER  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Acetylcholine;Address;Affect;Animals;Anxiety;Attention;Auditory;Behavior;Cells;cholinergic;Code;Cognitive;cognitive function;cognitive process;Computer Models;Cues;Darkness;Data;Data Science;Detection;Development;Diagonal Band of Broca;entorhinal cortex;experimental study;Fiber;Foundations;Frequencies;Future;Goals;Grant;innovation;Light;Link;Location;Major Depressive Disorder;Maps;Medial;Memory;Memory impairment;Mental Depression;Mental disorders;millisecond;Mission;Modality;Modeling;Monitor;Movement;Mus;National Institute of Mental Health;network models;neural;Neuromodulator;neuronal circuitry;Neurons;neuroregulation;optogenetics;Outcome;Pattern;Periodicals;Periodicity;Phase;Photometry;preservation;Process;Public Health;Research;Research Personnel;response;Retrieval;Rodent;Role;Running;Schizophrenia;Sensory;sensory input;Short-Term Memory;Signal Transduction;skills;spatial memory;Speed;Testing;Time;Training;Update;Vision;Visual;Work

PROJECT_TITLE: The Role of Sensory Inputs and Cholinergic Modulation for the Coding of Location and Movement Speed in the Entorhinal Cortex

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative A growing body of evidence including our own studies suggest that biological differences contribute to the lower treatment response and poorer survival experienced by African American women with Triple Negative Breast Cancer (TNBC), an aggressive breast cancer subset. We have established a highly synergistic inter- institution collaboration in order to enable detailed molecular analysis of TNBCs in African American women and to correlate the findings with treatment outcomes. These studies will be complemented by experiments to test new treatment approaches and find predictive biomarkers, all focused on developing more effective and personalized approaches to treatment of TNBC in the African American population.

PI_NAMEs: ELLISEN, LEIF W (contact);KO, NAOMI YU

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: Accounting;Address;Adjuvant Chemotherapy;African American;African American population;African American Women;aggressive breast cancer;Area;Biological;Biological Markers;Biology;Boston;Breast Cancer Patient;Cancer Biology;cancer cell;cancer health disparity;Cells;Characteristics;Chemoresistance;Clinical;clinical care;clinical translation;cohort;Cohort Analysis;Collaborations;Consensus;Data;Demographic Factors;Disease;Disease Progression;Disparity;driver mutation;drug sensitivity;Epigenetic Process;epigenetic silencing;epigenomic profiling;Excess Mortality;experience;experimental study;FBXW7 gene;Gene Expression Profiling;Genes;Genomics;Germ-Line Mutation;Heterogeneity;homologous recombination;homologous recombination deficiency;Hospitals;Inferior;innovation;insight;inter-institutional;Investigation;Malignant Breast Neoplasm;Measures;Medical center;Methodology;Methylation;Minor;Molecular Analysis;molecular subtypes;mortality;Mutation;Neoadjuvant Therapy;neoplastic cell;New England;novel;novel therapeutic intervention;novel therapeutics;Outcome;outcome disparities;outcome prediction;Pathway interactions;patient derived xenograft model;Patients;personalized approach;personalized medicine;Pharmacology Study;Population;predictive marker;Prevalence;prognostic;Publishing;Race;racial difference;Relapse;Research;Research Personnel;Residual Neoplasm;Resistance;response;safety net;single cell analysis;single-cell RNA sequencing;sociodemographic factors;Socioeconomic Status;Somatic Mutation;Specimen;subclonal heterogeneity;Survival Rate;Testing;Therapeutic;Tissue Microarray;Treatment outcome;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Suppressor Proteins;Underserved Population;White Women;Woman;Work

PROJECT_TITLE: Subclonal heterogeneity and outcome disparities in Triple-Negative Breast Cancer among African Americans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: PROJECT NARRATIVE  Nucleotide repeat expansions in C9-ALS/FTD produce toxic DPR proteins that are synthesized from an unusual initiation codon but are elongated by the classical ribosomal machinery using components of the tRNA pool one codon at a time. Little is known how the composition of the tRNA pool affects the disease outcome, although the repetitive use of a tRNA in high demand can deplete its charging with the cognate amino acid and its maturation with necessary modifications. Here, we will determine the quality of the tRNA pool in patient- derived and in control cells between the iPSC and the differentiated iPSN state to provide new insight that is important for understanding the disease and for exploring new therapeutic potential.

PI_NAMEs: HOU, YA-MING  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Address;Adult;Affect;age related neurodegeneration;ALS patients;Amino Acids;Amyotrophic Lateral Sclerosis;Animal Model;Anticodon;Award;Base Sequence;bench to bedside;Biological Models;Biology;Brain;C9ORF72;Cell model;Cells;Charge;Chemicals;Chimeric Proteins;Codon Nucleotides;Cognitive;curative treatments;Data;design;Development;Dipeptides;Disease;Disease Outcome;Foundations;frontal lobe;frontier;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genes;Genetic;Genetic Transcription;genome-wide analysis;improved;induced pluripotent stem cell;Initiator Codon;insight;interest;Introns;Length;Link;loss of function;Mediating;Medical;Messenger RNA;methyl group;Modeling;Modification;motor neuron degeneration;Neurodegenerative Disorders;Neuronal Differentiation;novel;novel therapeutics;Nucleosides;Nucleotides;Onset of illness;Pathogenesis;Pathology;patient derived induced pluripotent stem cells;Patients;Positioning Attribute;posttranscriptional;programs;Protein Biosynthesis;Proteins;Reading Frames;Regulation;Reporter;Research;Ribosomal Frameshifting;Ribosomal Proteins;Ribosomes;RNA;Role;Running;Sampling;Secure;Temporal Lobe;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;Transfer RNA;Transfer RNA Aminoacylation;Translating;Translation Initiation;Translations;United States National Institutes of Health;Work

PROJECT_TITLE: The tRNA pool in C9-ALS/FTD


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE The proposed work seeks to answer important outstanding questions about the function and regulation of the actin cytoskeleton using infectious microbes as cell-biological tools. The actin cytoskeleton plays critical roles in basic cell features and behaviors including shape, migration, division, and intracellular transport, and its misregulation is a crucial contributor to pathogenesis, for example, in inflammation, cardiovascular disease, cancer metastasis, and microbial infection. Therefore, understanding actin regulation and function may lead to new approaches for diagnosing and treating human disease.

PI_NAMEs: WELCH, MATTHEW D (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Address;Baculoviruses;Behavior;Biochemical;Biological;Biological Process;Burkholderia;Cardiovascular Diseases;cell behavior;Cell Communication;Cell fusion;Cell membrane;Cell Nucleus;Cell Physiology;Cells;Cellular biology;Cytoplasm;Cytoskeleton;Diagnosis;Disease;Event;Extracellular Matrix;Functional disorder;Funding;Gene Expression;Genetic;host colonization;host-microbe interactions;Human;human disease;imaging approach;Infection;Inflammation;insight;Intracellular Transport;Knowledge;Membrane;Methods;Microbe;microbial;Microbiology;migration;Modeling;Molecular;Movement;Mycobacterium marinum;National Institute of General Medical Sciences;Neoplasm Metastasis;novel strategies;Nuclear;Nuclear Envelope;Nucleopolyhedrovirus;Pathogenesis;Play;polymerization;Polymers;Positioning Attribute;prevent;Property;Regulation;Research;response;Role;Shapes;tool;Work

PROJECT_TITLE: Microbial mobilization of the actin cytoskeleton

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: SAN DIEGO

ORG_NAME: SHARP MEMORIAL HOSPITAL

PHR: PROJECT NARRATIVE The Eunice Kennedy Shriver NICHD Neonatal Research Network works collaboratively to conduct large multicenter clinical trials and observational studies to facilitate the conduct of neonatal medicine, with the goal of improving the health of low birth weight and premature infants. Sharp Mary Birch Hospital for Women & Newborns, and its satellite Sharp Grossmont Hospital; both Level III NICUs, can contribute academically and provide top-level enrollment of participants as a clinical center – Sharp Neonatal Research Institute (NRI). The Sharp NRI, through its highly experienced investigative team and history of successful participation in multiple published clinical trials, offers the Network an exceptional environment for an outstanding research institute that will help will expedite enrollment and help assure high neurodevelopmental follow-up compliance in current and future Network trials.

PI_NAMEs: KATHERIA, ANUP C (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Admission activity;Age;Algorithms;antenatal;Beds;Betula Genus;Binding Sites;Birth;California;Certification;Clinic;Clinical;clinical care;clinical center;Clinical Research;Clinical Trials;Clinical Trials Design;Closure by clamp;cohort;Collaborations;community center;Community Hospitals;Conduct Clinical Trials;Consent;County;Coupled;COVID-19 pandemic;design;Doctor of Philosophy;eligible participant;Enrollment;Environment;Evaluation;experience;extreme prematurity;Failure;Family;follow-up;Future;Gestational Age;Goals;Health;Health Insurance Portability and Accountability Act;Healthcare Systems;high risk;high risk infant;Hispanic;Home visitation;Hospitalization;Hospitals;Hour;Human Resources;improved;Infant;Inpatients;Joints;Leadership;Low Birth Weight Infant;Medicine;Milk;Mission;Multi-Institutional Clinical Trial;Multicenter Neonatal Research Network;Multicenter Trials;Multiple Pregnancy;National Institute of Child Health and Human Development;natural hypothermia;Necrotizing Enterocolitis;Neonatal;neonatal encephalopathy;neonate;Neonatology;Newborn Infant;Nurse Practitioners;Observational Study;Operative Surgical Procedures;Outcome;pandemic disease;Participant;participant enrollment;Patient Care;patient population;Patients;Pediatric Nursing;Population;premature;Premature Infant;Process;process improvement;Productivity;programs;Provider;Publishing;Randomized Controlled Clinical Trials;randomized trial;Randomized, Controlled Trials;Recording of previous events;recruit;Research;Research Institute;Research Personnel;Research Project Summaries;Research Support;response;Services;Site;Specialist;Standardization;support network;Text Messaging;Therapeutic;Training;Transfusion;treatment planning;trial design;trial enrollment;Umbilical cord structure;Woman;Work

PROJECT_TITLE: Sharp Neonatal Research Institute Clinical Center (Sharp NRI-CC)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative We propose a proof-of-concept trial in Parkinson disease (PD) to test whether 2 years of citalopram, compared to placebo, can alter the build-up of toxic amyloid-beta plaques in the visuospatial cortex of the brain linked to visuospatial cognitive impairment in PD. This project is relevant to public health because it aims to test and validate a new approach to reduce biomarkers related to dementia risk in a common neurologic condition.

PI_NAMEs: KOTAGAL, VIKAS  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: abeta accumulation;Address;Affect;alpha synuclein;Alzheimer's Disease;Alzheimer's disease diagnostic;Alzheimer's disease related dementia;Amyloid beta-42;Amyloid beta-Protein;Area;Attention;Biological;Biological Markers;Biostatistics Core;Brain;Cerebrospinal Fluid;Characteristics;Citalopram;Clinical;Clinical Research;Clinical Trials;clinically relevant;Cognition;Cognition Disorders;Cognitive;cognitive function;cognitive impairment in Parkinson's;cognitive testing;Complex;Confidence Intervals;Data;Data Set;Dementia;dementia risk;Development;Diagnosis;efficacy trial;executive function;Future;Goals;human old age (65+);Impaired cognition;Impairment;Intervention;Judgment;Knowledge;Laboratory Research;Lewy Bodies;Link;Measures;Mediating;Mental Depression;Modeling;Nature;Nerve Degeneration;Neurologic;Neurons;neurotransmission;novel strategies;Outcome;Parietal;Parkinson Disease;Parkinson's Dementia;Pathogenesis;Pathologic;Pathology;Pharmaceutical Preparations;Pittsburgh Compound-B;Placebo Control;placebo group;Placebos;Positron-Emission Tomography;Prevention approach;Prevention therapy;Prevention trial;preventive intervention;Primary Prevention;Public Health;Publishing;Randomized;Research;Risk;Risk Factors;Selective Serotonin Reuptake Inhibitor;Senile Plaques;Serotonin;tau aggregation;Tauopathies;Testing;Time;Toxic effect;Vascular Cognitive Impairment;Verbal Learning;Visuospatial

PROJECT_TITLE: Citalopram as a posterior cortical protective therapy in Parkinson disease


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Cancer;Lung;Lung Cancer

ORG_CITY: SAINT PAUL

ORG_NAME: QUENCH MEDICAL, INC.

ORG_STATE: MN

PHR: Project Narrative  Lung cancer is the leading cause of cancer mortality with a 5-year survival rate of less than 20% following standard of care treatment. There is strong evidence that targeted delivery of inhaled chemotherapy medication to the lung at a fraction of the current dose will have a major impact on increasing survival and reducing lung tumor burden in lung cancer patients with far less side effects than those associated with current systemic intravenous chemotherapy. Based on preliminary data, we will develop a novel inhaled chemotherapy treatment in order to directly target pulmonary tumors in order to improve survival in lung cancer patients.

PI_NAMEs: BEVERLIN II, BRYCE  (contact)

PROGRAM_OFFICER_NAME: POND, MONIQUE ADRIANNE

PROJECT_TERMS: Address;Aerosols;Blood Volume;Bypass;Cancer Etiology;Cancer Patient;Cells;Characteristics;chemotherapy;Circulation;Clinical;Clinical Research;Combination Drug Therapy;commercialization;Data;Deposition;Dose;Drug Delivery Systems;drug development;Dryness;Effectiveness;efficacy study;Electroencephalography;Elements;Equipment Contamination;Excipients;first-in-human;Formulation;gemcitabine;good laboratory practice;Growth;Histologic;Human;Immunotherapy;improved;In Vitro;in vivo;Inhalation;Inhalation Toxicology;Inhalators;innovation;Intravenous;Investigational Drugs;Investigational New Drug Application;Lead;Leucine;Lung;Lung Neoplasms;Malignant neoplasm of lung;manufacture;Maximum Tolerated Dose;Medical;Medical Staff;Medicine;Metabolism;meter;Methods;mortality;National Heart, Lung, and Blood Institute;Nebulizer;Non-Small-Cell Lung Carcinoma;novel;Oncology;Operative Surgical Procedures;Oral cavity;Outcome;particle;Pathway interactions;Patients;Penetration;Performance;Peripheral;Pharmaceutical Preparations;Pharmacotherapy;Pharyngeal structure;Phase;Powder dose form;pre-clinical;preclinical study;Production;Research;Risk;Rodent;Rodent Model;Route;Safety;scale up;side effect;Small Business Innovation Research Grant;Sodium Chloride;standard of care;Survival Rate;systemic toxicity;targeted delivery;Techniques;Technology;Testing;Therapeutic;Toxicokinetics;Toxicology;translational potential;Translations;Treatment outcome;tumor;Tumor Burden;Tumor Tissue;United States Food and Drug Administration;United States National Institutes of Health;Universities;Virginia;Wettability;Work

PROJECT_TITLE: Treating non-small cell lung tumors with a novel inhaled dry powder chemotherapeutic formulation


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Premature birth is a major socioeconomic problem that affects 10-15% of pregnancies and causes 70-80% of neonatal mortality and morbidity. Clearly, the final phase of fetal development is best achieved in a healthy womb environment rather than in the neonatal intensive care unit. To this end, we must develop effective treatments to prevent preterm birth. Our goal is to elucidate the mechanism by which the steroid hormone progesterone exerts anti-inflammatory effects in uterine smooth muscle cells to promote uterine relaxation and quiescence for most of pregnancy, and how those actions are withdrawn to induce parturition; especially inflammation-induced preterm labor. The proposed research tests a novel mechanism by which inflammatory stimuli induce preterm labor by modulating progesterone signaling in myometrial cells via progesterone receptor phosphorylation. A clear understanding of this process may reveal novel therapeutic targets to decrease the burden of prematurity by lowering the risk for inflammation-induced preterm birth.

PI_NAMEs: MESIANO, SAM ANTONIO (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Address;Affect;Anti-Inflammatory Agents;Antiinflammatory Effect;Binding;Biological Assay;Biological Models;Birth;Cell Line;Cells;Cesarean section;clinically significant;Complex;Data;Development;Discipline of obstetrics;effective therapy;Environment;experimental study;Fetal Development;Freezing;Gene Modified;gene repression;Generations;Genes;Genetic Transcription;Goals;Gravid;Hormonal;Hormones;Human;Human Biology;IL8 gene;In Vitro;in vivo;Induced Labor;Infection;Inflammation;Inflammatory;innovation;intrauterine infection;Knowledge;Labor Onset;Link;Macaca mulatta;Maps;Mediating;Mitogen-Activated Protein Kinases;Modeling;Molecular;mouse model;Mus;Myometrial;myometrium;Neonatal Intensive Care Units;neonatal morbidity;Neonatal Mortality;new therapeutic target;novel;Nuclear;Pathway interactions;Phase;Phosphorylation;Play;Pregnancy;premature;Premature Birth;Premature Labor;prevent;Process;Progesterone;Progesterone Receptors;promoter;Protein Isoforms;Protein Kinase;PTGS2 gene;Publishing;Reagent;receptor;Receptor Signaling;Regulation;Relaxation;Repression;Research;response;Response Elements;Risk;Role;Serine;Signal Pathway;Signal Transduction;socioeconomics;steroid hormone;Stimulus;stressor;Testing;Tissues;transcription factor;Transcription Factor AP-1;uterine smooth muscle cell;Uterus;Withdrawal;Woman;Work

PROJECT_TITLE: A novel mechanism for inflammation-induced preterm birth via PR-A phosphorylation

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: OVERALL : NARRATIVE The Center of Excellence in Environmental Toxicology (CEET) conducts research that links environmental exposures, to adverse outcomes and translates its findings to human subjects and communities to identify the most vulnerable and improve prevention, intervention and treatment through precision public health. Bi- directional communication through the Community Engagement Core helps set the research agenda of the CEET and inform public health decision making.

PI_NAMEs: PENNING, TREVOR M (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Address;adverse outcome;Air Pollution;Applications Grants;Area;Artificial Intelligence;Asbestos;Award;Big Data;Biological Assay;Biological Markers;Biology;Biosensor;career;career development;cheminformatics;Cities;Communication;Communities;community engaged research;community engagement;Core Facility;Data;Data Set;Decision Making;Disease;Doctor of Philosophy;Educational workshop;Endowment;environment related cancer;Environmental Exposure;Environmental Health;environmental toxicology;exposed human population;flexibility;Funding;Goals;Health;Health Professional;health science research;Health Sciences;Home;Human;human disease;human subject;Human Subject Research;improved;Informatics;Institution;Integrative Medicine;Intervention;Knowledge;Laboratories;lead exposure;Link;lung health;Machine Learning;Measures;medical schools;member;Mentors;Mission;Modeling;National Institute of Environmental Health Sciences;Neurosciences;next generation;Pathway interactions;Pattern Recognition;Pediatric Hospitals;Pediatrics;Pennsylvania;Pharmacology;phenome;Philadelphia;Pilot Projects;Population;Positioning Attribute;Predisposition;Prevention;professor;programs;Public Health;Public Health Schools;recruit;Research;Research Design;Research Personnel;Resources;response;Schools;Science;Scientist;Services;skills;Strategic Planning;Structure;Superfund;Time;tool;Toxic effect;Toxicology;Training Programs;Translating;Translational Research;Translations;Universities;urban area;Vulnerable Populations;wasting

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(P)]


NIH_SPENDING_CATS: Data Science;Social Determinants of Health

PROJECT_TERMS: Address;Administrator;adverse outcome;Advisory Committees;Air Pollution;Applications Grants;Appointment;Area;Attention;Big Data;bioinformatics tool;Biological Markers;Biology;career;Collaborations;Communication;Communities;community engagement;Community Healthcare;Computational Science;Continuing Education;Core Facility;data to knowledge;Decision Making;design;Discipline;Educational workshop;Endowment;Ensure;environment related cancer;Environmental Exposure;Environmental Health;environmental toxicology;Epidemiology;Evaluation;experience;Familiarity;flexibility;Fostering;Goals;Grant;Health Professional;health science research;Health Sciences;Informatics;Institution;Integrative Medicine;International;Leadership;lung health;Machine Learning;meetings;member;Mentorship;National Institute of Environmental Health Sciences;Neurosciences;next generation;Patients;Pediatrics;Pharmacology;Philosophy;Policy Maker;Predisposition;Process;professor;programs;Progress Reports;Public Health;Reporting;Research;Research Personnel;Resources;Schedule;Science;Scientist;Seasons;Series;Services;skills training;social media;Strategic Planning;Strategic vision;Stress;Structure;success;symposium;Time;tool;Toxicology;Translational Research;Translations;Vision;web site;working group

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS]


ORG_DEPT: PEDIATRICS

PHR: The NICHD Neonatal Research Network was established by the NICHD in 1986 to rapidly design, conduct, and publish clinical studies to improve the health of neonates. We are one of only two centers that have continuously contributed to the NRN in every cycle since 1986. Our medical and nursing staffs firmly believe that patients benefit from research. Our large diverse inborn delivery service with essentially no loss to back transport is ideal for neonatal clinical trials. We eagerly anticipate participating in the next cycle of the NRN and will continue to lead and innovate.

PI_NAMEs: HIBBS, ANNA MARIA  (contact)

PROJECT_TERMS: Adherence;antenatal;Area;Back;bench-to-bedside translation;Birth;Caring;Childhood;Clinical;clinical center;Clinical Research;Clinical Trials;Collaborations;Complement;Consent;Data;Data Analyses;Dedications;design;Development;Enrollment;Ensure;experience;Exposure to;Family;follow-up;Goals;Health;health equity;Health system;Healthcare;high risk;high standard;Holidays;Hospitals;Hour;Human Resources;Human Subject Research;improved;Infant;Infant Health;innovation;Lactation;Lead;Leadership;Longterm Follow-up;Lung Diseases;Maternal-fetal medicine;Medical;medical schools;Medical Staff;Mentors;Mothers;Multicenter Neonatal Research Network;National Institute of Child Health and Human Development;Neonatal;neonatal health;Neonatal Intensive Care Units;neonate;Neonatology;neurodevelopment;Newborn Infant;novel;Nursing Research;Nursing Staff;Observational Study;Operative Surgical Procedures;Opioid;Outcome;Patient Care;patient population;Patients;pediatric department;Pediatric Hospitals;Performance;Personnel Recruitments;Persons;Population Heterogeneity;Procedures;Productivity;programs;Protocols documentation;Publications;Publishing;recruit;Reproducibility;Reproductive Biology;Research;Research Personnel;Role;School-Age Population;Science;service delivery;skills;socioeconomic disadvantage;tool;translational research program;transmission process;Universities;University Hospitals;Woman

PROJECT_TITLE: NICHD Neonatal Research Network Clinical Center - Case Western Reserve University


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

PI_NAMEs: VACHANI, ANIL  (contact)

PROJECT_TERMS: Address;adverse outcome;Affect;Air Pollutants;Air Pollution;analytical method;Area;Back;Basic Science;Big Data;biobank;Bioinformatics;Biological;Biological Markers;Biology;biomarker validation;biomedical informatics;Biometry;Biosensor;Cells;Clinical;Clinical Research;Clinical Trials;Collection;combustible cigarette;Communication;Communities;community based participatory research;community engagement;Core Facility;cytate;Data;data management;Database Management Systems;density;design;Development;Disease;Disease Management;disorder risk;Electronic cigarette;Electronic Health Record;environment related cancer;Environmental Exposure;Environmental Health;environmental toxicology;epidemiology study;exposed human population;Exposure to;Fostering;fundamental research;genetic information;Health Sciences;high dimensionality;Human;Human Resources;human subject;imaging study;Individual;Informatics;Information Dissemination;innovation;Institutional Review Boards;Integrative Medicine;Intervention Trial;Laboratories;lung health;Maps;Measures;member;Mission;Nature;Neurosciences;non-genetic;novel;Observational Study;Outcome;Participant;patient oriented research;Patients;Performance;Phenotype;Pilot Projects;Population;Population Sciences;pre-clinical;preclinical study;predictive marker;Predisposition;prevent;preventive intervention;Process;Prognostic Marker;Public Health;Publications;quality assurance;Questionnaires;Reader;Recording of previous events;recruit;Research;Research Design;Research Personnel;Research Subjects;Research Support;Resources;Retrospective Studies;Risk;Sampling;Services;Specimen Handling;Statistical Data Interpretation;Statistical Methods;Strategic vision;Technology;Testing;Therapeutic Intervention;tool;Toxicant exposure;Toxicokinetics;Training Activity;training opportunity;Training Support;Translating;Translational Research;translational study;Translations;vapor;virtual;Work

PROJECT_TITLE: Integrative Health Sciences Facility Core


NIH_SPENDING_CATS: Biotechnology;Prevention;Social Determinants of Health

PI_NAMEs: BLAIR, IAN ALEXANDER (contact)

PROJECT_TERMS: Air Pollution;Animal Model;Area;Asbestos;assay development;Biological Assay;Biological Markers;Biological Models;Biology;biomarker development;biomarker discovery;biomarker identification;Cell Culture Techniques;cohort;Cohort Studies;Computer software;Core Facility;Data;data integration;Disease;Disease Progression;Education;Educational workshop;environment related cancer;Environmental Exposure;Environmental Health;environmental toxicology;Equipment;Etiology;genetic variant;Genomics;Goals;Health Sciences;Heavy Metals;Human;Human Subject Research;improved;Individual;Inductively Coupled Plasma Mass Spectrometry;Informatics;instrument;instrumentation;Integrative Medicine;interest;Ions;Liquid Chromatography;liquid chromatography mass spectrometry;lung health;Mass Spectrum Analysis;Measures;metabolome;metabolomics;Metals;Methodology;Methods;Modeling;Neurosciences;novel diagnostics;Onset of illness;Patients;Phase;Phenotype;Pilot Projects;Population;Predisposition;prognostic indicator;Proteins;Proteomics;Public Health;Reporter;Research Design;Research Personnel;Resolution;Risk Assessment;Sampling;Scheme;Sensitivity and Specificity;Services;specific biomarkers;stable isotope;Strategic vision;Training;transcriptome;transcriptomics;Translating;treatment response;Validation;Vulnerable Populations

PROJECT_TITLE: Translational Biomarker Facility  Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: VOIGHT, BENJAMIN FRANKLIN (contact)

PROJECT_TERMS: adverse outcome;Air Pollution;Area;Artificial Intelligence;Award;Big Data;Bioinformatics;Biological Markers;Biological Specimen Banks;Biology;biomedical informatics;Biosensor;Communities;computer program;computer science;Computer software;Computing Methodologies;computing resources;Consultations;Core Facility;Data;Data Analyses;data dissemination;data integration;data management;Data Science;Data Sources;data to knowledge;data visualization;Databases;Dedications;Degree program;Development;early experience;Education;Educational workshop;electronic health data;Electronic Health Record;Ensure;environment related cancer;Environmental Exposure;Environmental Health;environmental toxicology;epigenomics;Equipment;Event;Exposure to;Genomics;Goals;Health Sciences;human subject;Human Subject Research;improved;Informatics;informatics infrastructure;informatics tool;innovation;Integrative Medicine;Knowledge;Link;lung health;Machine Learning;Measures;metabolomics;Molecular;Multiomic Data;National Institute of Environmental Health Sciences;Neurosciences;next generation sequencing;Office of Administrative Management;open source;Organism;Outcome;Pathway interactions;Patients;Pilot Projects;population health;Population Research;Predisposition;Process;Proteomics;Public Health;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resource Informatics;Role;Services;skills;Software Engineering;Source;Strategic Planning;tool;Toxicology;Training;transcriptomics;Vision;Visual;website development;Work

PROJECT_TITLE: Exposure Biology Informatics Facility Core


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Diabetes;Wound Healing and Care

ORG_CITY: Chicago

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE In diabetes mellitus, downstream complications such as diabetic neuropathy and vascular damage lead to impaired wound healing, which can result in severe, non-healing ulcers of the lower extremities that may require amputation. Advances in wound healing research have identified some potential mechanisms for this impaired healing, but treatments for diabetic ulcers are lacking in comparison to the overall improvement in the management of diabetes. To that end, this work aims to further understand the inherent deficits in diabetic skin by determining the effects of topically applied novel small molecule NRF2 activators on wound healing and tissue integrity in diabetic wounds and investigating the mechanisms driving their effects.

PI_NAMEs: BARAKAT, MAY  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Amputation;angiogenesis;Antioxidants;Automobile Driving;Basement membrane;Binding;Biological Assay;Biological Models;Blood Vessels;catalase;Chronic;chronic ulcer;chronic wound;Collagen;Complication;Cytoprotection;Data;db/db mouse;Defect;Development;diabetes management;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Neuropathies;diabetic patient;diabetic ulcer;diabetic wound healing;Economic Burden;Equilibrium;Exhibits;experimental study;Gene Expression;Genes;Genomics;Goals;healing;Histologic;Human;Hydrogen Peroxide;Impaired healing;Impaired wound healing;Impairment;improved;In Vitro;in vivo;in vivo Model;Inflammation;innovation;insight;Investigation;Lead;Leg Ulcer;Life;Lipid Peroxides;Lower Extremity;Macrophage;Measures;Medical;Methods;Morbidity - disease rate;mortality;Mus;Neuropathy;non-diabetic;non-healing wounds;novel;nuclear factor-erythroid 2;Outcome;Oxidative Stress;Pathology;Pathway Analysis;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Prevention;Process;protective pathway;re-epithelialization;Research;response;restoration;Role;Skin;small molecule;social;Solubility;Specificity;Superoxide Dismutase;Testing;Time;Tissues;tool;Topical application;transcription factor;transcriptome;transcriptome sequencing;treatment effect;Vascular Diseases;Work;wound;wound care;wound closure;wound healing;Wound healing therapy;wound treatment

PROJECT_TITLE: NRF2 Activation in Diabetic Wound Healing


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health

PI_NAMEs: HOWARTH, MARILYN  (contact)

PROJECT_TERMS: Address;Aging;Air Pollution;Area;Back;Child;Cities;Collaborations;Communication;Communities;community based participatory research;community collaboration;community engaged research;community engagement;Community Participation;Core Facility;Data Collection;design;Disadvantaged;Education and Outreach;Elderly;environment related cancer;Environmental Exposure;Environmental Health;Environmental Medicine;Environmental Science;environmental toxicology;Evaluation;experience;Funding;Grant;Health;health knowledge;health literacy;Health Policy;Health Professional;Health Sciences;improved;Industrialization;Infrastructure;innovation;Integrative Medicine;lead exposure;Learning;Logic;lung health;Medical;member;Mission;Modeling;Needs Assessment;Neurosciences;Occupational Medicine;Outcome;Pennsylvania;Philadelphia;Policies;Policy Maker;Population;Predisposition;Process;programs;Public Health;Public Policy;Publications;Research;Research Design;Research Personnel;Research Priority;Residencies;Rural Community;Science;Scientist;Services;Strategic vision;success;tool;Translating;Translational Research;Translations;Vulnerable Populations;Work

PROJECT_TITLE: Community Engagement Facility  Core


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: SIMMONS, REBECCA A (contact)

PROJECT_TERMS: Address;Air Pollution;Applications Grants;Area;Award;Back;Biological Markers;Biology;career development;Categories;Communities;community engaged research;community partners;Core Facility;cost;Data;Educational workshop;environment related cancer;Environmental Exposure;Environmental Health;environmental toxicology;Extramural Activities;Faculty;falls;Funding;Funding Mechanisms;Grant;health science research;Health Sciences;human subject;Informatics;innovation;Integrative Medicine;interest;K-Series Research Career Programs;lung health;member;Mentors;Mentorship;Methods;National Institute of Environmental Health Sciences;Neurosciences;new technology;Outcome;Phase;Pilot Projects;Population;Predisposition;Process;programs;Publications;recruit;Rejuvenation;Research;Research Personnel;Research Support;response;Running;Scientist;senior faculty;Series;Services;Study Subject;Technology;Time;United States National Institutes of Health;Update;Wages;Writing

PROJECT_TITLE: Pilot Project Program


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BALTIMORE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative  Image guided surgery is widely used to safely navigate around complex structures like the ethmoid bone and critical structures such as the brain; its utility is greatly enhanced when coupled with intraoperative radiographic imaging because the anatomic changes caused by surgery are clearly elucidated and can be incorporated into the surgical plan. This project will develop computational methods that exploit readily available endoscopic video to improve the accuracy of navigation and to provide intraoperative updates to the anatomic model. This technology will enhance surgical decisions in the operating room and enable precise navigation throughout the surgery without the need for additional radiologic imaging in the operating room.

PI_NAMEs: HAGER, GREGORY DONALD (contact);ISHII, MASARU

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: 3-Dimensional;Address;Anatomic Models;Anatomy;Brain;Cadaver;Clinical;cohort;Complex;Computer Vision Systems;Computing Methodologies;cost;Coupled;Data;Decision Making;Detection;Devices;Documentation;effectiveness evaluation;Endoscopes;Ethmoid bone structure;Eye;Geometry;Goals;Image;Image-Guided Surgery;improved;interest;Investigation;Learning;Methods;millimeter;Modeling;Monitor;novel;Operating Rooms;operation;Operative Surgical Procedures;Optics;Patients;Performance;Postoperative Period;Procedures;Psyche structure;Radiation exposure;radiological imaging;reconstruction;Safety;Sinus;Slice;Speed;Structure;Surface;Surgeon;System;Technology;tool;Touch sensation;United States National Institutes of Health;Update;usability;Vision;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Improved Surgical Navigation Using Video-CT Registration

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE To capture the expression profile of patients diagnosed with frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), we will employ an innovative sequencing technology. We will use this expression profile to discover and validate urgently needed biomarkers, to find targets for treatments, and to increase our understanding of these debilitating diseases.

PI_NAMEs: GENDRON, TANIA FRANCE;VAN BLITTERSWIJK, MARKA  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Acceleration;ALS patients;Alternative Splicing;Amyotrophic Lateral Sclerosis;Autopsy;Binding Proteins;Biological Markers;biomarker discovery;Blood;Blood specimen;Brain;brain tissue;C-terminal;C9ORF72;Candidate Disease Gene;candidate marker;causal variant;Cell Culture Techniques;Cell model;Cell Nucleus;cell type;Cerebellum;Clinical;Clinical Trials;cohort;Collection;Complex;Cultured Cells;Cytoplasmic Protein;Data;Defect;Diagnosis;diagnostic biomarker;Disease;druggable target;Event;Exhibits;frontal lobe;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Future;Genes;Genetic;Genetic Transcription;in vivo;Individual;innovation;insight;Investigation;Length;Measurable;Messenger RNA;Methods;Modeling;Molecular;Molecular Profiling;mRNA Stability;mRNA Translation;Mutation;Neuroanatomy;Neurodegenerative Disorders;neuropathology;new therapeutic target;novel;novel marker;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;pharmacodynamic biomarker;Phosphorylation;Play;Poly(A) Tail;Poly(A)-Binding Proteins;potential biomarker;Preparation;profiles in patients;Prognostic Marker;Property;protein function;protein TDP-43;Proteins;Recovery;RNA;RNA Processing;RNA Splicing;RNA-Binding Proteins;Role;sample collection;single nucleus RNA-sequencing;Specimen;stathmin;Stress;System;targeted treatment;Techniques;Technology;Testing;Therapeutic Intervention;Time;Tissues;Transcript;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;Transportation;Variant;variant detection

PROJECT_TITLE: Frontotemporal dementia and related disorders: transcriptomic profiling, biomarker discovery, and mechanistic insight

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-L(02)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: YAOUNDE

ORG_COUNTRY: CAMEROON

ORG_FIPS: CM

ORG_NAME: CENTRE FOR RESEARCH IN INFECTIOUS DISEASES - CRID

PHR: Project Narrative The use of neonicotinoids in agricultural pest management is contributing to reduce the susceptibility of mosquito populations to clothianidin, a neonicotinoid recently approved for use in indoor residual spraying targeting malaria vectors. Our project aims to test whether the utility of clothianidin in public health is currently being threatened in some agricultural regions in Africa. This research will be very important to preserve the efficacy of this active ingredient in malaria vector control. !

PI_NAMEs: KAMGANG, BASILE  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Active Sites;Address;Africa;Africa South of the Sahara;African;agricultural activity;agricultural region;Agriculture;Anopheles gambiae;Anopheles Genus;Area;burden of illness;Cameroon;Collaborations;combat;Communicable Diseases;Country;Culicidae;Dangerousness;Development;Drug Metabolic Detoxication;Effectiveness;Environmental Risk Factor;Enzymes;Evaluation;experimental study;farmer;fighting;Formulation;Fostering;functional genomics;Generations;Genes;Genetic;genomic locus;genomic tools;Genomics;Geography;Goals;Incidence;Insecticide Resistance;Insecticides;Institution;International;Intervention;intervention cost;Knowledge;Malaria;Measures;Medicine;meetings;Metabolic;Monitor;Mutation;National Institute of Allergy and Infectious Disease;new technology;novel;Outcome;overexpression;Plasmodium;Play;Population;Predisposition;preservation;prevent;programs;Public Health;Recommendation;Research;Research Proposals;Residual state;Resistance;Resistance development;resistance gene;Role;Schools;Speed;Technology Transfer;Testing;Transgenic Organisms;vector;vector control;vector mosquito;World Health Organization

PROJECT_TITLE: Monitoring the development of resistance to the novel insecticide clothianidin in Anopheles gambiae

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(55)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Human Genome;Infectious Diseases;Liver Cancer;Liver Disease;Orphan Drug;Precision Medicine;Rare Diseases

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE  Hepatitis B virus-related hepatocellular carcinoma (HBV+ HCC) attributes to 85% of all HCC cases in China, and therapeutic options are limited. This project will forge a collaboration between a computational team in the US and an HCC oncology team in China to perform comprehensive molecular characterization of a large Chinese HBV+ HCC cohort using the new proteogenomic approach that systematically integrates genomics and mass spectrometry-based proteomics data. This collaborative project will produce new biomarkers, drug targets, and therapeutic agents for the prognosis and treatment of HCC as well as experimentally validated computational methods that can be broadly applied to proteogenomic studies in other cancer types and other diseases.

PI_NAMEs: ZHANG, BING  (contact)

PROGRAM_OFFICER_NAME: RODRIGUEZ, HENRY

PROJECT_TERMS: Animal Model;Antigens;Automobile Driving;Biological Assay;Biological Markers;Biology;biomarker selection;biomarker validation;Cancer Etiology;cancer type;Cell Line;Cells;Cessation of life;China;Chinese;Classification;Clinical;cohort;Collaborations;Colon Carcinoma;Computer Analysis;Computing Methodologies;Data;Data Analyses;Data Set;Development;Disease;DNA Sequence Alteration;Drug Targeting;forging;Funding;Generations;Genetic;Genome;genomic platform;Genomics;Growth;Hepatitis B Virus;Immune;Immune Evasion;Immunofluorescence Immunologic;immunogenicity;Immunophenotyping;Immunotherapy;in silico;International;Knowledge;Machine Learning;Malignant neoplasm of liver;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Messenger RNA;Modeling;Molecular;Monitor;mouse model;Multiomic Data;multiple omics;National Cancer Institute;neoantigens;next generation sequencing;novel therapeutics;Oncology;Outcome;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phase I Clinical Trials;Phenotype;phosphoproteomics;Primary carcinoma of the liver cells;Prognosis;prognostic;prognostic model;programs;Prospective cohort;protein biomarkers;Proteins;proteogenomics;Proteomics;Publishing;Reaction;Recommendation;Research;Research Personnel;Resources;RNA analysis;small molecule;Specimen;targeted agent;Techniques;Technology;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;Training;transcriptome sequencing;transcriptomics;Translating;treatment strategy;tumor;tumor microenvironment;Validation

PROJECT_TITLE: Proteogenomics-driven therapeutic discovery in hepatocellular carcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-M(50)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Recent landmark studies have provided evidence that “small vessel” coronary dysfunction in patients with otherwise normal coronary arteries is a major cause of heart disease and can lead to poor health outcomes including heart failure. This research proposal seeks to develop a noninvasive approach for diagnosis and monitoring of small-vessel coronary dysfunction by developing innovative and reliable magnetic resonance imaging strategies. Our proposal has the potential to improve patient care in this population by providing a noninvasive alternative to the established invasive testing procedure, which carries a risk of complications and is only available at highly specialized medical centers.

PI_NAMEs: SHARIF, BEHZAD  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: adverse event risk;Animals;Blood flow;Blood Vessels;Breathing;Cardiac;Clinical;Coronary;Coronary Arteriosclerosis;Coronary artery;Coronary Vessel Anomalies;Coronary Vessels;Darkness;Data;Detection;Diagnosis;Diagnostic tests;Diet;Echocardiography;Endothelium;Evaluation;Event;experience;Funding;Health;Heart Diseases;Heart failure;heart imaging;Heterogeneity;high resolution imaging;high risk;Hypertrophy;Image;image guided;image reconstruction;imaging approach;Impairment;improved;indexing;innovation;Ischemia;Machine Learning;Magnetic Resonance Imaging;Measurement;Medical center;Methods;Microcirculation;Microspheres;Microvascular Dysfunction;Monitor;Morphologic artifacts;Myocardial;Myocardial Ischemia;Myocardial perfusion;Nature;Non-Invasive Detection;novel;novel therapeutics;Patient Care;Patients;Performance;perfusion imaging;personalized medicine;Physiologic pulse;Physiology;poor health outcome;Population;porcine model;Positron-Emission Tomography;Procedures;Prognosis;Quality of life;recruit;Reference Standards;Research Personnel;Research Proposals;Resolution;Risk;Scanning;sequence learning;Severities;Staging;Stenosis;Stress;stress reduction;Systole;Techniques;Testing;Vascular resistance;Vasodilator Agents;Work

PROJECT_TITLE: Noninvasive Testing of Coronary Microvascular Reactivity Using High-resolution Free-breathing MRI

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: DA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Tobacco

PHR: PROJECT NARRATIVE Smoking, drinking, and illicit drug use are major sources of morbidity and mortality in the population, and all of these behaviors tend to begin in adolescence. Monitoring the Future (MTF) has played a vital role in measuring, tracking, and understanding these behaviors among American adolescents and adults from 1975 through the present. This application is to continue this important work from 2022/23 through 2026/27 by conducting annual, national surveys of 8th, 10th, and 12th grade students that include questions on more than 50 categories of substances, and analyzing these data in conjunction with longitudinal data from the existing and new MTF panels (a companion R01 application requests funding to continue to collect panel data).

PI_NAMEs: MIECH, RICHARD A (contact)

PROGRAM_OFFICER_NAME: LOPEZ, MARSHA

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;Adult;Advertising;Age;age related changes;Alcohol consumption;Alcohols;American;Annual Reports;aspirate;Attitude;Basic Science;Behavior;Behavioral;Belief;Cannabis policy;Categories;Cessation of life;Characteristics;cohort;Cohort Effect;Cohort Studies;college;Communities;Companions;COVID-19;Data;data archive;Deposition;design;Development;drinking;Drug Prescriptions;Drug usage;Drunk driving;Education;Educational workshop;eighth grade;Epidemiology;Ethnic Origin;Etiology;Event;experience;Family member;follow-up;Funding;Future;Gender;Goals;graduate school;Grant;Health;Heterogeneity;high school;HIV;HIV/AIDS;Home;illicit drug use;Illicit Drugs;improved;indexing;Individual;Injections;Knowledge;Legal;Life Style;Literature;longitudinal design;Longitudinal trends;Measurement;Measures;Medical;Mental Health;Modality;Monitor;Morbidity - disease rate;mortality;National Institute of Drug Abuse;Needle Sharing;Nicotine;novel therapeutics;Occupational;Pattern;peer;Performance;Personal Satisfaction;Persons;Pharmaceutical Preparations;physical conditioning;Play;Policies;policy implication;Population;Prevalence;Prevention;programs;protective behavior;psychologic;Race;Recording of previous events;Reporting;Request for Applications;Research;Research Personnel;research study;Retirement;Risk;Risk Behaviors;Role;role model;Sampling;Schools;Sex Behavior;Smoking;social;social determinants;Social Environment;socioeconomics;Source;Students;Subcategory;Subgroup;substance misuse;substance use;Substance Use Disorder;Surveys;Symptoms;Teenagers;tenth grade;Testing;Tobacco;tobacco products;Tobacco use;Training;transmission process;trend;twelfth grade;United States National Institutes of Health;university student;vaping;Work;Youth

PROJECT_TITLE: Monitoring the Future: Drug Use and Lifestyles of American Youth

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative: We currently know very little about the cells that make up our eardrum, how they function to help us hear, or how problems with them cause diseases of the ear. This study uses cutting edge molecular tools to gain a deeper understanding of what these cells are and how they function. With a better understanding of these cells, we should be able to come up with better treatments for patients currently suffering of diseases of the ear canal and eardrum.

PI_NAMEs: TWARD, AARON  (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Ablation;Adult;Air;Algorithms;Architecture;Behavior;Bioinformatics;Biological;Biological Models;biophysical properties;Cell Differentiation process;Cell Physiology;Cell Separation;cell type;Cells;Cholesteatoma;Chronic;Cluster Analysis;Connective Tissue;Data;Defect;design;Development;Disease;Dissection;Dissociation;Dyes;Ear;Ear Diseases;Environment;Epithelium;experimental study;External auditory canal;external ear auricle;Foundations;Gene Expression Profile;Gene Modified;healing;Hearing;Heterogeneity;Homeostasis;Human;Immunohistochemistry;improved;In Situ Hybridization;in vivo;Individual;inhibitor;injured;Injury;keratinocyte;Keratosis;Knockout Mice;Knowledge;Label;Labyrinth;Learning;Liquid substance;live cell imaging;LoxP-flanked allele;Maintenance;Malleus;Mammals;Mesenchymal;middle ear;migration;Modeling;Molecular;monomer;mouse model;Movement;Mucous Membrane;Mus;novel;Operative Surgical Procedures;Organoids;Otitis;Pathologic;Patients;PDGFRB gene;Perforation;pharmacologic;Physiologic pulse;Physiology;Platelet-Derived Growth Factor alpha Receptor;Population;Procedures;Process;progenitor;Proliferating;Radial;Reconstructive Surgical Procedures;repaired;Reporter;Research;response to injury;restoration;Signal Pathway;single-cell RNA sequencing;small molecule;small molecule inhibitor;sound;Stains;stem;stem cell population;stem cells;Stratified Squamous Epithelium;Structure;System;Therapeutic;tool;translation to humans;Tympanic membrane;Tympanic Membrane Perforation;Tympanostomy;vibration

PROJECT_TITLE: Tympanic membrane progenitor cells in homeostasis in injury

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Otitis Media;Pediatric;Prevention

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE Via our long-standing efforts to develop novel approaches for the better management and prevention of otitis media (OM), we have extensively characterized the functionality of antibodies directed against two unique biofilm-associated determinants of nontypeable Haemophilus influenzae (NTHI) that both prevent biofilm formation and, uniquely, disrupt pre-existing biofilms in vitro and in vivo. Action of these antibodies release this predominant otopathogen from its protected residence within the biofilm into a highly vulnerable ‘newly released’ (NRel) state, a recently discovered phenotype which is the most sensitive to killing by traditional antibiotics, and extends our understanding beyond the heretofore believed duality that bacteria responsible for chronic and recurrent diseases exist only in either a ‘planktonic’ or ‘biofilm-resident’ state. In consideration of a recent paradigm shift, wherein thought leaders have challenged us to consider new ways to combine the power of induced immunity with the more considered use of antibiotics as our “last hope against multi-drug resistant bacteria and persistent disease” as a means to achieve the strongest possible therapeutic outcome, herein we have designed studies that will expand upon compelling preliminary data to use specifically targeted antibodies to force recalcitrant biofilm-resident NTHI into the highly vulnerable NRel state so they can now be readily eliminated, and thereby leverage our new understanding to more effectively combat NTHI-induced OM and multiple other diseases caused by this high priority, antibiotic-resistant pathogen.

PI_NAMEs: BAKALETZ, LAUREN O (contact)

PROJECT_TERMS: 3-Dimensional;Acute;Affect;Aggressive course;Anatomy;Antibiotic Resistance;Antibiotics;Antibodies;antimicrobial;Bacteria;Bacterial Antibiotic Resistance;Biology;Black race;burden of illness;Characteristics;Child;Chronic;Chronic Disease;chronic infection;Clinical;combat;combinatorial;Complex;cost;Data;design;Development;Diarrhea;Disease;Dose;drug resistant pathogen;effective therapy;Equilibrium;Exanthema;follow-up;Future;Gene Expression;genetic risk factor;Goals;gut microbiome;Haemophilus influenza virulence;Human;human disease;Immune;Immune system;Immunity;Immunologics;Immunology;In Vitro;in vitro Assay;in vivo;Incidence;Individual;Intervention;Kinetics;Life;Mediating;Microbial Biofilms;Microbiology;middle ear;Moraxella catarrhalis;Multiple Bacterial Drug Resistance;Nature;neonate;Nontypable Haemophilus influenza;novel;novel drug class;novel strategies;Oral;Otitis;Otitis Media;Otorrhea;pathogen;Pathogenesis;Pathway interactions;Phenotype;Pneumococcal conjugate vaccine;polymicrobial biofilm;Population;Preclinical Testing;prevent;Prevention;Process;Proteins;Published Comment;Recurrence;Recurrent disease;recurrent infection;Research Design;residence;Resistance;response;Serum;socioeconomics;Streptococcus pneumoniae;structural biology;success;Suppurative Otitis Media;Systems Development;therapeutically effective;therapy outcome;Time;Translating;Tube;Tympanostomy;vaccine development;Vaccines;Vulnerable Populations;Writing

PROJECT_TITLE: Determinants of H. influenzae Virulence in Otitis Media

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Contraception/Reproduction;HIV/AIDS;Infectious Diseases;Nanotechnology;Prevention;Topical Microbicides;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: PUBLIC HEALTH RELEVANCE Next generation multipurpose prevention technologies that comprise of contraceptive and HIV prevention are urgently needed especially among at-risk women. We propose to develop a long-acting nanofluidic implant offering 2-year constant contraceptive and antiretroviral co-delivery, in a discreet, user-independent and safe manner for long-term use. Successful completion of our proposed work will yield a dual prevention product for advancement towards clinical development to provide women a single, convenient approach to protect their sexual and reproductive health.

PI_NAMEs: GRATTONI, ALESSANDRO  (contact);STAYTON, PATRICK S.

PROGRAM_OFFICER_NAME: PORTER, KRISTEN AMY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adopted;Age;AIDS prevention;Anti-Retroviral Agents;Cause of Death;Clinical;clinical development;clinical translation;Cold Chains;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;Dapivirine;design;Developing Countries;Diffusion;Dose;Drug Combinations;Drug Delivery Systems;Drug Kinetics;drug release kinetics;Drug Stability;efficacy evaluation;Etonogestrel;Exhibits;experience;FDA approved;Formulation;Future;Goals;Health;High Risk Woman;HIV;HIV anti-retroviral;HIV Infections;Hormonal;hormonal contraception;Human;hydrophilicity;Implant;implantable device;implantation;improved;Individual;innovation;Ion Channel;Kinetics;Lead;low and middle-income countries;Macaca nemestrina;Maternal Mortality;Membrane;Methods;Modernization;nanochannel;nanofluidic;next generation;nonhuman primate;Oral;patient oriented;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;Pharmacology;pill;Polymers;Positioning Attribute;pre-clinical;pre-exposure prophylaxis;preference;Pregnancy;pregnancy prevention;Prevention;Prevention strategy;Preventive;Prodrugs;Progestins;prophylactic;public health relevance;Pump;Rattus;Recommendation;Regimen;reproductive;Research;Resistance;response;Retrieval;Risk;Safety;Scanning Electron Microscopy;sexual and reproductive health;sexually active;simian human immunodeficiency virus;social stigma;Stigmatization;Structure;subcutaneous;Tail;Technology;technology platform;Testing;Tissues;unintended pregnancy;uptake;Vagina;Vaginal Ring;viral transmission;Virus Diseases;Woman;Work;World Health Organization

PROJECT_TITLE: Long-acting multi prevention implant for 2-year contraception and HIV PrEP

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Aging;Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation;Sleep Research

PHR: PROJECT NARRATIVE  Sleep dysfunction is common and disabling across a wide range of neurological and psychiatric conditions, leading to worsening daytime symptoms, accelerating disease progression and marking a major public health challenge. In patients with Parkinson’s disease, we will use chronically implanted cortical and basal ganglia electrodes plus sensing-enabled closed-loop Deep Brain Stimulation to evaluate which neural structures, signals and connections are disrupted by pathological oscillations in sleep. Understanding the fundamental mechanisms of sleep dysfunction represents a key knowledge gap preventing forward progress in developing precision neuromodulation therapies for sleep, secondary motor / non-motor symptoms and potentially disease progression in Parkinson’s disease.

PI_NAMEs: LITTLE, SIMON  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Acceleration;addiction;Address;Alzheimer's Disease;Anxiety;Basal Ganglia;Beta Rhythm;Bipolar Disorder;Chronic;cohort;cost;Craniocerebral Trauma;Data;Deep Brain Stimulation;Dementia;Development;Devices;Disabling;Disease;Disease Progression;Electrodes;Epilepsy;experience;explainable machine learning;Foundations;Ganglia;Goals;Headache;Home;Implant;improvement on sleep;innovation;Knowledge;Laboratories;Link;Machine Learning;Measures;Mental Depression;Modeling;Modernization;Motor;motor symptom;Multiple Sclerosis;network models;neural;Neurodegenerative Disorders;Neurologic;neurophysiology;neuropsychiatric symptom;neuroregulation;non rapid eye movement;non-motor symptom;nonhuman primate;novel strategies;Outcome;Parasomnias;Parkinson Disease;Pathologic;Patients;Persons;Phase;Physiological;Polysomnography;precision neuromodulation;prevent;Psychoses;Public Health;rapid eye movement;REM Sleep;Research;Research Priority;Resolution;response;Risk Factors;Schizophrenia;Signal Transduction;Site;Sleep;sleep abnormalities;Sleep Architecture;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;Sleep Stages;Slow-Wave Sleep;Stroke;Structure;Symptoms;Techniques;Therapeutic;Work

PROJECT_TITLE: Determining the circuits and signals of sleep dysfunction in Parkinson's disease through chronic intracranial recordings and closed-loop Deep Brain Stimulation

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Arthritis;Biotechnology;Chronic Pain;Dental, Oral, and Craniofacial Disease;Osteoarthritis;Pain Research;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE Arthritis in the temporomandibular joint (TMJ) refers to the degradation of the cartilage and death of cells in the joint. In this proposal, we define how degradation of cartilage is communicated to the cell and how this process suppresses mechanisms that protect against cell death. This work will define new mechanisms that initiate TMJ arthritis and new potential therapeutic targets to attenuate or reverse the disease.

PI_NAMEs: REED, DAVID ANDREW (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Acceleration;Address;Affect;Apoptosis;Arthritis;arthropathies;Attenuated;Autophagocytosis;Binding;Biochemical;Bioreactors;Cartilage;cartilage degradation;Cartilage Diseases;Cell Death;Cells;Chondrocytes;Clinical;Collagen Type VI;Communication;cost;CSPG4 gene;Cytoprotection;Data;Degenerative polyarthritis;design;Disease;Early Intervention;Endocytosis;experimental study;Exposure to;Extracellular Matrix;Fibroblasts;Flow Cytometry;FRAP1 gene;Functional disorder;Goals;Health;Hip region structure;Histology;Human;immunocytochemistry;Immunohistochemistry;Impairment;In Vitro;in vivo;Induced Neurons;Inflammatory;inhibitor;Injury;innovation;Integrin Binding;joint injury;joint mobilization;Joints;Knockout Mice;Knowledge;Limb structure;Link;Maintenance;Mandible;Mechanical Stress;Mechanics;Mediating;Membrane;Modeling;Molecular;Monoclonal Antibodies;mouse model;neuron loss;novel;novel therapeutic intervention;Operative Surgical Procedures;Outcome;Pain;Pathogenesis;Pathology;Pathway interactions;Patients;Population;pre-clinical;Process;Proteoglycan;Proteolysis;Quality of life;receptor;Regulation;Replacement Arthroplasty;Reporting;Research;response;response to injury;Reverse Transcriptase Polymerase Chain Reaction;Role;Signal Transduction;Sirolimus;Stress;Temporomandibular Joint;Temporomandibular Joint Disorders;Testing;therapeutic target;Western Blotting;Work

PROJECT_TITLE: Cell-Matrix Regulation of Fibrochondrocytes in TMJ OA

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE  Acute Myeloid Leukemia (AML) is a cancer of the immature myeloid cells of the bone marrow. Current treatments are associated with significant, even life threatening, side effects. This project will define the role of the CBFB-MYH11 oncogene and its co-factor HDAC1 in regulating leukemia maintenance, and test whether inhibitors of these proteins have the potential to cure CBFB-MYH11 driven AML. Successful completion of this project will provide important new insights into the biology of leukemia cells and lead to significant improvements in the treatment of AML.

PI_NAMEs: HYDE, RICIA KATHERINE (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Affect;Allogenic;Apoptosis;Binding;Biology;Bone Marrow;CBFB gene;CBFbeta-MYH11 fusion protein;Cells;chimeric gene;Chimeric Proteins;Chromosomal Rearrangement;Chromosome 16;Chromosome inversion;Clinical;Co-Immunoprecipitations;cofactor;Combined Modality Therapy;Complex;Core-Binding Factor;Dasatinib;Development;Disease;DNA;DNA Binding;driver mutation;Drug Targeting;Event;experience;experimental study;Family;Family member;fusion gene;gain of function;Gene Expression;Gene Fusion;Genes;Genetic;Genetic Transcription;Goals;Growth;HDAC1 gene;Hematopoiesis;hematopoietic differentiation;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Heterodimerization;High Dose Chemotherapy;Histone Deacetylase Inhibitor;improved;improved outcome;In Vitro;in vivo;inhibitor;insight;knock-down;Knock-in Mouse;leukemia;Leukemic Cell;Life;Maintenance;Malignant Neoplasms;Modeling;Molecular;Molecular Target;mouse model;Mus;Mutate;Mutation;Myelogenous;Myeloid Cells;MYH11 gene;neoplastic;new therapeutic target;novel;novel therapeutics;Oncogenes;Outcome;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Perception;Pharmaceutical Preparations;pharmacologic;Prognostic Marker;protein complex;Protein Tyrosine Kinase;Proteins;Recurrence;Relapse;relapse patients;Repression;Role;RUNX1 gene;side effect;small hairpin RNA;standard care;Testing;therapy outcome;tool;Toxic effect;transcription factor;Transcriptional Activation;Tumor Suppressor Genes;Work

PROJECT_TITLE: The Role of the CBFB-MYH11 Complex in Leukemia Maintenance


NIH_SPENDING_CATS: Genetics

PHR: PROJECT NARRATIVE Efficient synthesis of thyroid hormone requires the secretion and iodination of the thyroglobulin protein; failure to secrete thyroglobulin leads to hypothyroidism. This grant concentrates on defective thyroglobulin secretion linked to thyroid cell death, which is connected to a range of very common clinical thyroid disorders.

PI_NAMEs: ARVAN, PETER  (contact)

PROGRAM_OFFICER_NAME: BURCH, HENRY B

PROJECT_TERMS: Age;Alleles;Animal Model;Animals;apical membrane;Attention;autosomal recessive trait;blocking factor;Breeding;Cell Death;cell growth;Cell membrane;Cells;Cessation of life;Clinical;Cretinism;Curiosities;cytotoxicity;Development;Diabetes Mellitus;Disease;Dwarfism;Endoplasmic Reticulum;endoplasmic reticulum stress;Engineering;Environment;Epithelial Cells;Evolution;Exhibits;Failure;Frequencies;Gene Mutation;Generations;Genetic;Glycoproteins;Goiter;Grant;Growth;Growth Disorders;Heterozygote;Homozygote;Human;human disease;Human Inbreeding;Hyperplasia;Hypothyroidism;in vivo;Inbreeding;Individual;Inflammatory Infiltrate;Ingestion;Inherited;Intake;Iodides;Iodination reaction;Knock-in;Knock-in Mouse;Knockout Mice;Life;Link;Livestock;Malignant neoplasm of thyroid;Malignant Neoplasms;Mediating;misfolded protein;Modeling;mouse model;Mus;mutant;Mutation;Nerve Degeneration;oxidation;Pathogenicity;Patients;Persons;Physiology;Population;Proliferating;protein degradation;Proteins;proteotoxicity;Rattus;Reporting;Role;Serum;Severities;Sheep;System;Testing;TG gene;Thyroglobulin;Thyroid Adenoma;Thyroid Diseases;Thyroid Gland;Thyroid Hormones;Thyroiditis;Thyroxine;Tissues;trafficking;Travel;Triiodothyronine

PROJECT_TITLE: Endoplasmic Reticulum stress and thyroid cell death

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: RIVERSIDE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: PROJECT NARRATIVE While it is known that stress can cause proteins to go to wrong locations inside the cell, the biochemical mechanisms and consequences are mostly unknown. We will characterize the causes, mechanisms, protein substrates, and consequences of stress-dependent secretory protein mistargeting inside human cells. The outcome will be to reveal how this stress-induced secretory protein mistargeting is related to the maintenance of human health.

PI_NAMEs: GENEREUX, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Affinity;ATF6 gene;Biochemical;biological adaptation to stress;Biological Assay;Biology;Cell Culture Techniques;Cell Death;cell type;Cells;Cessation of life;Chemicals;Client;Coupled;Cytosol;Development;Diabetes Mellitus;Disease;Endoplasmic Reticulum;endoplasmic reticulum stress;experience;Experimental Designs;Foundations;Functional disorder;Health;Heat shock proteins;Human;Impairment;Individual;Intervention;Investigation;Label;Location;Maintenance;Mass Spectrum Analysis;Measures;Mediating;Membrane Proteins;Methodology;misfolded protein;Modeling;Molecular Conformation;multicatalytic endopeptidase complex;Neurodegenerative Disorders;new technology;non-Native;novel;Outcome;Pathway interactions;Physiological;Post-Translational Protein Processing;Predisposition;prevent;Process;Protein translocation;Proteins;Proteome;Proteomics;proteostasis;proteotoxicity;Quality Control;Reporting;Research;Research Personnel;response;Role;Route;Secretory Cell;secretory protein;sensor;Series;Signal Pathway;Stress;stressor;System;Triage;Ubiquitin

PROJECT_TITLE: Characterizing Stress-dependent Secretory Protein Mistargeting

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHIATRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Behavioral Activation (BA) psychotherapy has emerged as a first-line treatment for adolescent depression, yet the underlying neurobiological mechanisms of BA’s efficacy remain unclear. A fuller understanding of BA’s targets of treatment engagement requires multiple assessments linking trajectories of behavioral and symptom change with trajectories of change in these neural circuits over the course of therapy as opposed to just pre/post comparisons. This study will provide insights that can be used to develop new treatment biomarkers, inform BA treatment augmentation, further novel treatment development, and facilitate precision-based psychotherapy interventions to more effectively treat this major public health problem.

PI_NAMEs: CRAIGHEAD, W. EDWARD (contact);TREADWAY, MICHAEL TILGHMAN

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent Development;Age;Amygdaloid structure;Anterior;avoidance behavior;Behavior assessment;Behavior Therapy;Behavioral;Behavioral Mechanisms;Biological Markers;child depression;Chronic;Clinical;Comprehension;contrast imaging;Corpus striatum structure;Cues;Data;Decision Making;depressive symptoms;design;Detection;Development;disability;Disease;Dorsal;Ecological momentary assessment;effective therapy;efficacious treatment;Emotions;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Goals;Grant;Image;imaging study;Individual;insight;Insula of Reil;interest;Intervention;Investigational Therapies;Knowledge;Link;Major Depressive Disorder;Measures;Mediating;Mediation;Mental Depression;Modeling;Modification;Monitor;Motivation;negative emotional state;neural;neural circuit;neurobiological mechanism;neuroimaging;neuromechanism;novel;Participant;Patients;Pattern;Population;positive emotional state;precision medicine;Prefrontal Cortex;Protocols documentation;Psychotherapy;Public Health;Research Domain Criteria;response;Rest;reward anticipation;Rewards;Risk;Sampling;Scanning;Schedule;Severities;social;Symptoms;targeted treatment;Techniques;Testing;Therapeutic Effect;Therapeutic Intervention;Therapeutic Research;therapy development;Treatment Efficacy;treatment response;Ventral Striatum;Waiting Lists

PROJECT_TITLE: Multi-level Mechanisms of Behavioral Activation Therapy for Adolescent Depression

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Clinical Trials and Supportive Activities;Lung;Pediatric;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: PROJECT NARRATIVE Pediatric acute respiratory distress syndrome (PARDS) is a form of severe lung injury that causes acute respiratory failure requiring mechanical ventilation (artificial respiration) in thousands of US children per year. While poorly studied in children, injurious mechanical ventilation practices have been associated with the development of new or progressive multiple organ dysfunction syndrome (NPMODS) and higher mortality in adults with ARDS. This proposal will use novel approaches to investigate the associations between mechanical ventilation management, NPMODS, and post-intensive care unit morbidity to identify focused mechanical ventilation interventions to target in future clinical trials in children with PARDS.

PI_NAMEs: BHALLA, ANOOPINDAR  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Acute respiratory failure;Adoption;Adult;Artificial Respiration;atelectrauma;Automobile Driving;Award;Biological;Biometry;Breathing;career;career development;Cessation of life;Chest wall structure;Child;Childhood;Clinical Trials;Clinical Trials Design;Community Healthcare;Coupled;Critical Care;Critical Illness;Critically ill children;Data;design;Development;Diagnosis;Enrollment;Esophagus;Family;follow-up;functional status;Funding;Future;Goals;Guidelines;health related quality of life;improved;Infrastructure;Intensive Care Units;Intervention;K-Series Research Career Programs;Lead;Learning;Lung;lung injury;lung pressure;Manometry;Measures;Mechanical ventilation;Mentors;Mentorship;Morbidity - disease rate;mortality;multidisciplinary;Multiple Organ Failure;Muscular Atrophy;National Heart, Lung, and Blood Institute;novel;novel strategies;Organ failure;Outcome;Outcomes Research;Patients;Pediatric Acute Respiratory Distress Syndrome;Phase;Physiological;Positioning Attribute;Positive-Pressure Respiration;pressure;prevent;primary outcome;Protocols documentation;Randomized;randomized trial;Randomized, Controlled Trials;Recovery;Research;Research Design;Research Personnel;Resources;respiratory;Respiratory physiology;Sample Size;secondary analysis;secondary outcome;shear stress;skill acquisition;skills;standard care;Statistical Data Interpretation;Survivors;Testing;Tidal Volume;Time;Training;Training Activity;United States;ventilation;Ventilator

PROJECT_TITLE: Mechanical Ventilation Management, New or Progressive MODS, and Post-ICU Morbidity in Pediatric ARDS

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breast Cancer;Cancer;Mental Health;Neurosciences;Sleep Research;Women's Health Research

ORG_CITY: MORGANTOWN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE Breast cancer is the most frequently diagnosed cancer in women. Advances in its detection and treatment have substantially increased long-term survival among patients with breast cancer, but there is considerable individual variability in the progression of the disease and the extent to which it dysregulates other important biological systems. The goal of the proposed research is to determine how tumors alter sleep and metabolism, which in turn can further compromise the health and well-being of breast cancer survivors.

PI_NAMEs: DEVRIES, ANNE COURTNEY;NELSON, RANDY J. (contact)

PROGRAM_OFFICER_NAME: PERLOFF, MARJORIE

PROJECT_TERMS: Affect;antagonist;Behavior;biological systems;Brain;Breast;Breast Cancer Patient;Breast Cancer survivor;cancer diagnosis;Cancer Etiology;Cancer Patient;cancer survivorship care;Cells;cognitive performance;Data;designer receptors exclusively activated by designer drugs;Detection;Diagnosis;Disease;Disease Progression;Etiology;experience;experimental study;feeding;genetic approach;ghrelin;Goals;Health;high risk;Hormones;Hour;hypocretin;Hypothalamic structure;Impaired cognition;Impairment;improved;improvement on sleep;Incidence;Individual;individual variation;Lateral;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mental Health;Messenger RNA;Metabolism;mood regulation;Mus;neural circuit;Neurons;neurotransmission;Outcome;Patients;Personal Satisfaction;pharmacologic;physical conditioning;Physiological;Physiology;Play;Population;psychologic;Quality of life;Regulation;Research;Resolution;Role;Serum;Signal Transduction;Sleep;Sleep Architecture;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep quality;social;Specificity;Supportive care;Survivors;Symptoms;Testing;tumor;tumor progression;Woman

PROJECT_TITLE: Mechanism Underlying Sleep Disruption by Mammary Tumors


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Individuals with psychosis are less motivated than healthy individuals to exert effort to obtain rewards on experimental tasks, deficits which are related to symptoms of amotivation and function in everyday life, but individuals with depression do not despite showing reduced responses to rewards. Here we extend our work to examine: a) the processes that contribute to social as well as monetary motivation; b) the differential role of dopamine function in psychosis versus mood pathology; and c) the longitudinal relations between cognitive control and motivation in the everyday lives of individuals with psychosis and mood pathology.

PI_NAMEs: BARCH, DEANNA  (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Address;Affective;Anhedonia;Award;Behavioral;Behavioral Paradigm;Bipolar Disorder;Cognition;Cognitive;cognitive control;cognitive system;cognitive testing;Corpus striatum structure;cost;Data;Decision Making;Development;Dissociation;Dopamine;Dorsal;Ecological momentary assessment;Etiology;Funding;goal oriented behavior;Image;Impaired cognition;Impairment;indexing;Individual;innovation;Learning;Life;Link;Literature;Major Depressive Disorder;Measures;Medial;Mental Depression;Methods;mobile computing;mobile sensing;Mood Disorders;Moods;motivated behavior;Motivation;neural;neuroimaging;neuromechanism;neuromelanin;novel;Parietal;Pathology;Pathway interactions;Patient Self-Report;Persons;pleasure;Positive Valence;Prefrontal Cortex;Process;programs;Progress Reports;psychologic;Psychoses;psychotic;psychotic depression;Psychotic Disorders;Public Health;Quality of life;recruit;Reporting;Research;Research Domain Criteria;response;Rewards;Role;Sampling;Schizoaffective Disorders;Schizophrenia;Science;social;Social Functioning;Support System;Symptoms;System;systems research;Testing;Time;United States National Institutes of Health;willingness;Work

PROJECT_TITLE: Effort-Based Decision Making and Motivated Behavior in Everyday Life

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS