NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Disability Research;Neurosciences;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stroke;Transplantation

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Stroke is a leading cause of significant, long-term disability; yet no medical therapies exist to improve recovery. Utilizing bioengineering methods, such as biomaterials and stem cell scaffolds, to interact with the nervous system provides new approaches to (1) improve functional stroke recovery and (2) understand recovery mechanisms. Our proposed project utilizes conductive polymers to electrically modulate stem cells and identify recovery pathways from stem cell biology to enhance the brain’s own recovery mechanisms.

PI_NAMEs: GEORGE, PAUL  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Ablation;Acute;acute stroke;Adult;Affect;Aftercare;Age;aged;animal old age;Animals;Antibodies;Array tomography;Biocompatible Materials;Biomedical Engineering;Brain;brain tissue;Caregivers;Caring;Cause of Death;Cells;Central Nervous System;Clinical Trials;Data;Differentiation Antigens;disability;early phase clinical trial;Electric Stimulation;Electrophysiology (science);Eligibility Determination;Embolectomy;endogenous stem cells;Environment;Equilibrium;functional improvement;Glycoproteins;high dimensionality;Imaging Techniques;Immune response;improved;Infarction;injured;innovation;Investigation;Label;Long term disability;mature animal;Mediating;Medical;Methods;microscopic imaging;multidisciplinary;Natural regeneration;nerve stem cell;Nervous System;neural repair;Neuronal Differentiation;novel strategies;Older Population;paracrine;Pathway interactions;Patients;pharmacologic;Play;Polymers;post stroke;pre-clinical;Production;progenitor;Property;Proteins;Publishing;Qualifying;Rattus;Recombinants;Recovery;Recovery of Function;recruit;release factor;repaired;Research;Resolution;Rodent;Rodent Model;Role;scaffold;Signal Transduction;Societies;Stains;stanniocalcin 2;Statistical Methods;stem cell biology;stem cell delivery;Stem Cell Factor;stem cell therapy;Stem cell transplant;stem cells;Stroke;stroke model;stroke patient;stroke recovery;stroke survivor;stroke therapy;Survivors;Synapses;System;Techniques;Testing;Therapeutic Studies;Tissues;transcriptome;translational model;Transplantation;United States;Use of New Techniques;Work;young adult

PROJECT_TITLE: A Conductive Polymer-Stem Cell System to Augment Endogenous Stroke Repair Mechanisms and Improve Functional Stroke Recovery

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: FARMINGTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: T his proposal is to study the role of COP1 in dendritic spines, cognition, and stress resilience. T he results from this study may enhance our understanding of the mechanisms underlying spine pathology, cognitive dysfunction, stress resilience, and may identify the novel targets for treating stress-related disorders.

PI_NAMEs: MA, XIN-MING  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Adult;Affect;Anxiety;Area;autism spectrum disorder;biological adaptation to stress;Bipolar Disorder;Brain;Brain-Derived Neurotrophic Factor;Chronic;Chronic stress;Cognition;Cognitive;Cognitive deficits;cognitive enhancement;cognitive function;cognitive system;conditional knockout;constitutive expression;Data;Dendritic Spines;density;Dependovirus;Development;Disease;DLG4 gene;Ensure;Excision;Frequencies;gene gun;genome wide association study;hippocampal pyramidal neuron;Hippocampus;Impaired cognition;Impairment;information processing;Intervention;Knockout Mice;Label;Learning;Maintenance;male;Medial;Mediating;Memory;memory recognition;Mental Depression;Mental disorders;Mental Health;Microscope;multicatalytic endopeptidase complex;Mus;Mutation;Neurons;novel;object recognition;Outcome Study;overexpression;Pathology;Play;postnatal;postsynaptic;Prefrontal Cortex;promoter;Prosencephalon;protein degradation;Proteins;Proteomics;Regulation;Research Domain Criteria;resilience;response;Risk Factors;Rodent;Role;sex;Shapes;spatial memory;Stress;stress related disorder;stress resilience;Synapses;synaptic function;Synaptic plasticity;synaptogenesis;Synaptophysin;System;Testing;Time;Ubiquitin;ubiquitin-protein ligase;Vertebral column;Visualization;Whole-Cell Recordings

PROJECT_TITLE: Role of COP1 in dendritic spines, cognition and stress resilience

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Microbiome

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative The human microbiome provides additional perspective into health and disease. This project aims to develop analytical methods for microbiome data analysis. The proposed approaches will facilitate microbiome-based discovery sciences.

PI_NAMEs: CHEN, JUN  (contact);ZHANG, XIANYANG

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Accounting;Address;analytical method;analytical tool;Attention;Biological Markers;biomarker discovery;Biometry;Characteristics;Charge;Clinic;Collaborations;Communities;Complex;Computer software;Consensus;Data;Data Analyses;Data Analytics;Data Correlations;data imputation;Data Set;design;Development;Disease;disease diagnosis;Experimental Designs;flexibility;Genome;Genomics;Goals;Grant;Health;Human;Human Microbiome;improved;individualized medicine;inter-individual variation;interest;Lead;Linear Models;Manuscripts;Medical;Medicine;metabolome;Metagenomics;Methodology;Methods;methylome;microbial;microbiome;microbiome analysis;microbiome composition;microbiome research;Modeling;multidimensional data;Multiomic Data;Nature;novel;open source;Phylogenetic Analysis;Phylogeny;Procedures;Prognosis;programs;Proteome;Regression Analysis;Research Design;Research Personnel;Role;Sample Size;Sampling;Scheme;Science;Scientific Advances and Accomplishments;Scientist;Signal Transduction;simulation;Statistical Data Interpretation;Statistical Methods;statistics;Structure;targeted treatment;Testing;theories;tool;transcriptome;Trees;two-dimensional;user friendly software;user-friendly

PROJECT_TITLE: Methods for microbiome compositional data

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative For the brain to function properly, neurons must form active and efficient circuitry during development by refining synaptic connections, where active neuronal connections stay (maintained) while inactive ones leave (eliminated). We will determine how neuronal connections decide to stay or leave by characterizing the molecular determinants of the refinement. Defects in synapse refinement have been implicated in various neurological and psychiatric disorders, and thus, our work will yield novel insights into the pathophysiology and treatment of such disorders.

PI_NAMEs: CHEN, CHINFEI ;UMEMORI, HISASHI  (contact)

PROJECT_TERMS: Astrocytes;autism spectrum disorder;Axon;Biosensor;Brain;Cell Adhesion Molecules;Data;Defect;design;Development;Disease;Dorsal;Equilibrium;Etiology;experience;experimental study;Eye;Fibroblast Growth Factor Receptor 2;Functional disorder;Image;Impairment;In Vitro;in vivo;insight;JAK2 gene;Lateral Geniculate Body;Mental disorders;Molecular;Mus;Mutant Strains Mice;Nervous System Disorder;neural;neural circuit;neural network;Neurons;neuropsychiatric disorder;novel;novel therapeutic intervention;Pathway interactions;Pattern;Physiological;Play;postnatal;postsynaptic neurons;prevent;Process;Protein Tyrosine Kinase;PTPNS1 gene;Punishment;Regulation;response;Retina;retinogeniculate;Role;Schizophrenia;segregation;Signal Transduction;Site;Structure;superior colliculus Corpora quadrigemina;Synapses;synaptogenesis;System;Testing;tool;two-photon;Visual;Visual System;Visualization;Work

PROJECT_TITLE: How do neurons in the brain decide to refine their synaptic connections in vivo?

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases;Patient Safety

ORG_CITY: ITHACA

ORG_NAME: HALOMINE, INC.

ORG_STATE: NY

PHR: Project Summary/Abstract In the US, about 1.7 million Healthcare-Associated Infections (HAls) occur in hospitals each year, resulting in 99,000 deaths and an estimated $20 billion in healthcare costs. According to previous reports, as much as one third of HAI cases can be attributed to environmental surfaces, namely “high touch” surfaces (e.g., bed rails, machine buttons, equipment), in hospitals. Self-sanitizing coatings, i.e., antimicrobial surfaces, are an ideal theoretical solution for eliminating persistent pathogens; however there has been no commercially available antimicrobial material which can achieve high biocidal efficacy against pathogens with other necessary attributes, such as easy to apply, broad material compatibility, no resistance development to pathogens, and cost-effective. HaloFilm™ is a breakthrough product. HaloFilm is a spray-on product that when dried leaves a thin transparent film on a surface. The film is a polymer composed of one repeating unit with a functional group that adheres to a surface, and another functional repeating unit that stabilizes the chlorine. HaloFilm turns the surface into a chlorine battery so when it is used with a chlorine-based disinfectants it will allow the surface to be covered with the same level of chlorine found in a pool. HaloFilm is the only product that can pass EPA testing protocols as the supplemental residual antimicrobial coatings and films against bacteria and an enveloped virus surrogate for SARS-CoV-2. In fact, the EPA tested 20 of commercial products and none of the spray-on products achieved the 3-log reduction against Phi6 that HaloFilm achieved. HaloFilm is Halomine Inc.’s first product and is protected by exclusively licensed patents from Auburn University and Cornell University and will be brought to market in 2023 in collaboration with Diversey, a $2.7 billion global hygiene and infection control company. In this Phase II we will continue development of our product category by deepening our understanding of its efficacy against pathogens that are problematic in healthcare environments, extend HaloFilm’s use by developing a wipe based HaloFilm product, and investigate potential for an optimum companion product that can maximize biocidal efficacy of the product in service.

PI_NAMEs: NKEMNGONG, CARINE  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TITLE: HaloFilm: a spray-on, re-chargeable, re-applicable antimicrobial coating


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE It is not clear why binge-eating episodes, and often other behaviors in people with binge-eating disorder (BED), are both impulsively initiated and inflexibly persistent, or why some people with BED binge eat more frequently than others. This study will examine whether abnormal connectivity within and between brain circuits during decision-making could contribute to hallmark features of BED and promote more severe forms of this disabling and often chronic disorder. Data from this project will inform a more precise explanatory model of BED symptoms and identify circuit-based targets for new treatments.

PI_NAMEs: BERNER, LAURA A. (contact);FIORE, VINCENZO GUIDO

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Adult;Age;American;Anorexia Nervosa;anorexia nervosa binge-purge subtype;Behavior;Behavior Control;Behavior Disorders;Behavioral;Binge Eating;Binge eating disorder;Body mass index;Brain;brain based;Bulimia;causal model;Characteristics;Chronic Disease;Clinical;Cognitive;Cognitive deficits;Computer Models;Corpus striatum structure;COVID-19;Data;Decision Making;Diagnosis;Diagnostic;disability;Disabling;Disease;Distress;Dopamine;Dorsal;Eating Behavior;Eating Disorders;eating pathology;efficacious intervention;Environment;Exanthema;experience;Exposure to;Feedback;Food;Frequencies;Functional Magnetic Resonance Imaging;Future;goal oriented behavior;Goals;Health;Heterogeneity;high reward;Human;Hyperphagia;Impairment;Impulsivity;indexing;Individual;Interruption;Intervention;Knowledge;Learning;Link;Matched Group;Measures;Medical;Modeling;Morbidity - disease rate;neural;neural circuit;neural model;Neurobiology;neuromechanism;Neurotransmitters;novel;Outcome;Patient Self-Report;Patients;Pattern;Persons;Phase;Pilot Projects;pre-clinical research;predictive modeling;Process;psychologic;Recurrence;reinforced behavior;Reporting;Research;response;Response to stimulus physiology;Role;Sensory;Severities;sex;simulation;Stimulus;suicidal;Symptoms;System;Testing;Theoretical model;theories;treatment response;Work

PROJECT_TITLE: The Computational Role of Corticostriatal Circuits in Binge-Eating Disorder Symptoms and Severity

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Sickle cell disease affects 100,000 people and 2,000 newborns each year; 50% of these children have a developmental deficit (>2 SD) before the age of 3. Early identification of developmental deficit supports timely intervention, but children with sickle cell disease are grossly underdiagnosed and undertreated. The goal of the proposed study is to determine the incidence and severity of developmental deficit at 9, 18 and 30 months of age among children with sickle cell disease and test a 12-month, home-based caregiver intervention with this disproportionately affected population.

PI_NAMEs: HOYT, CATHERINE ROSE (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: 3 year old;Academy;Address;Adult;Affect;African ancestry;Age;Age Months;American;American Society of Hematology;Assessment tool;Award;Black race;career;career development;caregiver education;caregiver interventions;Caregivers;Child;Child Development;Child health care;Child Rearing;Child Welfare;Clinical Research;Cognition;Cognitive;cognitive development;cohort;Collaborations;comparison control;comparison group;Complex;cost effective intervention;Data;Development;Development Plans;Developmental Delay Disorders;Diagnosis;Doctor of Philosophy;early experience;Early identification;Early Intervention;Education;Educational Curriculum;Educational Intervention;Environment;Evaluation;Evidence based intervention;Family;Family member;feasibility testing;Funding;Future;Goals;Grant;Guidelines;Health;Healthcare Systems;Home;Home environment;Home visitation;Human;Impaired cognition;implementation science;implementation strategy;improved;improved outcome;Incidence;infancy;Infant;Infant Development;Infection;Inflammation;Inherited;innovation;Institutional Racism;Intervention;Interview;Laboratories;Life;life span;Measures;Medical Care Team;Mendelian disorder;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Missouri;multidisciplinary;Names;National Heart, Lung, and Blood Institute;Neuronal Plasticity;Newborn Infant;Nursery Schools;Occupational Therapist;Outcome;Outcome Measure;Pain;Parents;patient population;Pediatric Hospitals;Pediatrics;peer;Persons;Pilot Projects;Population;Poverty;Preparation;Prevention;programs;prospective;Protocols documentation;Randomized, Controlled Trials;Readiness;Recommendation;recruit;Rehabilitation therapy;Research;research and development;scale up;School-Age Population;Schools;Scientist;screening;service intervention;Severities;Sickle Cell;Sickle Cell Anemia;skills;social culture;standardize measure;Stroke;success;teacher;Testing;theories;Therapeutic Intervention;therapeutically effective;therapy development;Time;Toddler;Training;trial design;Unemployment;United States;Visit;Work

PROJECT_TITLE: Early Identification Of Developmental Delay Among Infants And Toddlers With Sickle Cell Disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Palliative Care

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Cancer remains the second leading cause of death in the United States, but most advanced cancer patients do not understand key information about their disease well enough to help them make informed healthcare decisions. The proposed study will address this public health issue by examining how psychological and physiological aspects of stress and anxiety may interfere with patients' accurate understanding, then by adapting and testing a stress management intervention to address these factors. The long-term goal of this work is to reduce stress-related barriers to informed decision-making, in order to improve quality of life and end-of-life care among those with cancer.

PI_NAMEs: DERRY-VICK, HEATHER  (contact)

PROGRAM_OFFICER_NAME: ACEVEDO, AMANDA MARIE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Advanced Malignant Neoplasm;anti-cancer research;Anxiety;anxiety reduction;Appointment;Area;Award;Behavioral Sciences;Benchmarking;biobehavior;Biofeedback;Biological Markers;cancer care;Cancer Patient;career;Cause of Death;Cessation of life;chemotherapy;Clinical;Clinical Trials;Code;Communication;Complex;coping;Data;Decision Making;Disease;Disease Progression;Disseminated Malignant Neoplasm;Distress;Educational Intervention;Elements;Emotions;end of life;end of life care;experience;Feedback;Foundations;Goals;Health;health care quality;Health Psychology;Healthcare;Hearing;Heart Rate;heart rate variability;improved;indexing;insight;Intervention;intervention effect;Interview;K-Series Research Career Programs;Laboratories;Lead;Leadership;Learning;Link;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant Neoplasms;Manuals;Measures;Medical;Medicine;Mentors;Mentorship;Methods;Modeling;Monitor;novel strategies;Observational Study;Oncology;Palliative Care;Pathway interactions;patient oriented;Patient Preferences;Patients;Pattern;Persons;Phase;Physicians;Physiological;pilot test;Positioning Attribute;preference;Process;Prognosis;prognostic;programs;psychologic;Psychological Factors;Psychologist;Psychophysiology;Public Health;Quality of Care;Quality of life;Randomized;randomized trial;Reaction;Reporting;Research;Research Personnel;Resources;Rest;routine imaging;Scanning;Science;secondary outcome;self-reported anxiety;skills;Stable Disease;statistics;Stress;stress management;stress reduction;Test Result;Testing;Training;Translating;treatment as usual;treatment response;tumor progression;United States;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Leveraging behavioral science to improve patient understanding of advanced cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE  GABAergic interneurons play key roles in the development and maintenance of the neocortex. This proposal will determine how interneurons that express somatostatin (SST-INs) contribute to the maturation of circuits underlying spontaneous and sensory-evoked neuronal activity in mouse visual cortex. We expect our findings to provide important insights into the cellular underpinnings of cortical development and visual processing by the brain.

PI_NAMEs: CARDIN, JESSICA A (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Adolescent;Age;Anatomy;area striata;autism spectrum disorder;Behavioral;Brain;Cells;cellular targeting;Data;Dendrites;Development;Disease;disease model;Electrophysiology (science);Epilepsy;Equilibrium;Exhibits;experimental study;Eye;Functional disorder;Goals;hippocampal pyramidal neuron;in vivo;insight;Interneurons;Investigation;Life;Maintenance;mature animal;Methodology;microscopic imaging;Monitor;Mus;Neocortex;neocortical;nerve supply;Neurodevelopmental Disorder;Neurons;neuropsychiatric disorder;neuroregulation;neurotransmission;optogenetics;Peptides;pharmacologic;Pharmacology;Play;Population;postnatal;postnatal development;postnatal period;postsynaptic;Regulation;response;Role;Schizophrenia;Sensory;Signal Transduction;Somatostatin;Stimulus;Synapses;Testing;Time;two-photon;vision development;Visual;Visual Cortex;visual processing;visual receptive field

PROJECT_TITLE: Impact of local network dynamics on visual cortex function

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Neurosciences;Sexually Transmitted Infections;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Neurotropic alphaherpesviruses are responsible for a range of human diseases including cold sores, blindness and birth defects. This proposal dissects the mechanisms of alphaherpesvirus assembly and trafficking within the nervous system, events that are essential for the progression and spread of infection.

PI_NAMEs: SMITH, GREGORY ALLAN;WILSON, DUNCAN W. (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Address;Afferent Neurons;Alphaherpesvirinae;anterograde transport;Axon;Axonal Transport;Bacterial Artificial Chromosomes;Binding;Biochemistry;Blindness;Capsid;Cell Line;Cell Nucleus;Cells;Cellular biology;Complex;Congenital Abnormality;Cytoplasmic Organelle;Development;Disease;DNA biosynthesis;ds-DNA;Episome;Epithelium;Event;experience;Family suidae;Fluorescence Microscopy;Gene Expression;Goals;Herpes Labialis;Herpesviridae;Herpesvirus 1;Human;human disease;Human Herpesvirus 2;human induced pluripotent stem cells;Image;In Vitro;in vivo;Induced pluripotent stem cell derived neurons;Infection;innovation;interest;Kinesin;Laboratories;mad itch virus;Mediating;Membrane Proteins;Microtubules;Molecular;Motor;Mucous Membrane;Nerve;Nervous System;neuronal cell body;neuronal transport;Neurons;neurotropic;Nose;novel;novel therapeutics;Oral;Organelles;Oropharyngeal;particle;pathogen;Pathogenesis;Pathway interactions;Periodicals;Principal Investigator;Process;protein complex;Proteins;reactivation from latency;recruit;Role;Simplexvirus;Structure;Structure of trigeminal ganglion;Surface;Testing;Tissues;trafficking;transmission process;Travel;Viral;Viral Genes;Viral Genome;Virion;Virus;Virus Replication

PROJECT_TITLE: Neurotropic herpesvirus envelopment and microtubule-mediated transport

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: MARTINEZ

ORG_NAME: HELLO ROBOT INC

ORG_STATE: CA

PHR: Project Narrative Assistive robots have the potential to enhance individual autonomy, reduce human burden, and lower healthcare costs associated with mild cognitive impairment, Alzheimer’s dementia, and mobility impairments for older adults, family care partners, and professional caregivers. StretchTM is a robot designed to support everyday activities through use of a lightweight telescoping arm mounted on a mobile base. Our research will develop and evaluate the Stretch Cognitive and Physical Assistant to support cognitive and physical tasks autonomously and through remote control.

PI_NAMEs: EDSINGER, AARON  (contact);ROGERS, WENDY A

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Area;arm;assistive robot;Award;base;care burden;care recipients;Caregivers;Caring;Categories;Characteristics;Clinical;Cognitive;commercialization;community planning;Cues;daily functioning;design;Diagnosis;Engineering;Environment;Evaluation;Family;flexibility;Floor;Health Care Costs;Home;Home environment;Home Ranges;Human;human old age (65+);Illinois;Impaired cognition;implementation facilitators;improved;Individual;Industry Standard;insight;Instruction;iterative design;Life;light weight;Marketing;member;Methods;mild cognitive impairment;Mobility decline;Monitor;neighborhood disadvantage;new technology;older adult;Older Population;Participant;Personal Satisfaction;Persons;Phase;physical impairment;Procedures;Protocols documentation;Quality of life;Readiness;recruit;remote control;remote health care;Research;Research Design;Research Methodology;Robot;Robotics;Rural Community;Safety;service delivery;Small Business Innovation Research Grant;Stretching;Tablets;Task Performances;Technology;Testing;theories;tool;United States National Institutes of Health;Universities;usability;Water;Work

PROJECT_TITLE: Stretching their Reach: Robotic Support for Older Individuals with Mild Cognitive Impairment, Early Alzheimer's Dementia, and Mobility Impairments


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Obesity;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Excess adiposity is independently associated with recurrence risk and death in hormone receptor-positive breast cancer, but, among non-Hispanic Black women and hormone-receptor negative breast cancer cases, associations are less clear. We will test the central hypothesis that adipose tissue depots (visceral vs. subcutaneous), measured using computed tomography scans, have differing associations with adipokine and adipokine receptor gene expression profiles and related gene signatures in the breast tumor microenvironment, which can be used to develop outcome predictive models. This high impact study will advance the field by yielding new data on how adipose tissue distribution impacts (1) gene expression profiles in the breast tumor microenvironment and (2) breast cancer outcomes, with an emphasis on the interplay among race and ethnicity and tumor subtype.

PI_NAMEs: FELICIANO, ELIZABETH MARJORIE CESPEDES;LLANOS, ADANA A. M. (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: adipokines;adiponectin;Adipose tissue;Asian Americans;Asian Women;Biological Markers;Black race;black women;Body Composition;Body fat;Body mass index;Breast Cancer Patient;Breast Cancer Risk Factor;Breast Cancer Treatment;California;Cancer Prognosis;cancer recurrence;cancer risk;cell type;Cells;Cessation of life;cohort;Complex;Computerized Medical Record;Data;Death Rate;Detection;Development;Drug or chemical Tissue Distribution;ERBB2 gene;ethnic diversity;Ethnic Origin;Ethnic Population;Exhibits;Fatty acid glycerol esters;Gene Expression;Gene Expression Profile;Genes;genetic signature;Genetic Transcription;high body mass index;Hip region structure;Hispanic Americans;Hispanic Women;hormone receptor-negative;hormone receptor-positive;improved;In Situ Hybridization;Incidence;indexing;individualized prevention;Inequity;insight;Intervention;LEPR gene;Leptin;leptin receptor;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Neoplasms;Measures;Modeling;Modification;mortality;Muscle;Nonmetastatic;Not Hispanic or Latino;novel;Obesity;Outcome;outcome prediction;Pacific Islander;Phenotype;Physiological;Precision therapeutics;predictive modeling;predictive signature;Prevalence;preventive intervention;Prognosis;programs;prospective;protein expression;Race;racial difference;racial diversity;racial population;receptor;receptor expression;Receptor Gene;Recurrence;Research;Resources;Risk;risk prediction;Risk Reduction;RNA;Role;Sampling;Scanning;Skin;Specimen;subcutaneous;Testing;Transcript;transcriptome sequencing;transcriptomics;tumor;Tumor Markers;tumor microenvironment;Tumor Subtype;Tumor Tissue;Variant;Visceral;waist circumference;Woman;women's diagnosis;X-Ray Computed Tomography

PROJECT_TITLE: Understanding the role of adiposity and adipokine-related RNA expression in the tumor microenvironment on breast cancer outcomes in a racially and ethnically diverse sample

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ORG_CITY: WORCESTER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative  Innate immunity plays a critical role in nearly all infectious and autoimmune diseases, and is very similar in nearly all animals. Thus, we propose to investigate the innate immune system of the fruit fly Drosophila melanogaster and how it responds to bacterial infection. This research may have a direct and profound impact on continuing efforts to modulate the immune response in mosquitoes, in order to reduce the transmission of vector-borne diseases such as malaria, West Nile Virus, or Zika. In addition, discoveries from this research have direct relevance to similar innate immune pathways in humans, which will also be investigated.

PI_NAMEs: SILVERMAN, NEAL  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: adaptive immunity;Address;Amyloid;amyloid fibril formation;Amyloid Fibrils;Animals;Anti-Inflammatory Agents;anti-microbial peptide;assault;Autoimmune Diseases;autoinflammatory diseases;Bacillus;Bacteria;Bacterial Infections;Binding;Biochemical;Biological;Biological Models;Cell surface;cell type;Cell Wall;Cells;Chemicals;Communicable Diseases;Culicidae;Cytosol;cytosolic receptor;Data;defense response;Development;disease model;Drosophila genus;Drosophila melanogaster;Event;Exhibits;Family;Fat Body;fly;Funding;Gene Expression;Genes;genetic resource;Germ Lines;Grant;Health;Homo;Human;Immune;Immune response;Immunity;immunodeficiency;Immunologic Receptors;Immunology;immunoregulation;Infection;Inflammatory;innate immune pathways;Innate Immune Response;Innate Immune System;Insect Vectors;Insecta;Invertebrates;Knock-out;Lead;Link;Malaria;Mammals;Methotrexate;Microbe;microbial;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Natural Immunity;novel strategies;novel therapeutics;Nuclear;nucleotide receptor;Nucleotides;Organ;Organism;Pathway interactions;Peptidoglycan;peptidoglycan receptor;peptidoglycan recognition protein;peroxisome;Phospholipids;Play;Process;Production;Publishing;receptor;Regulation;Research;response;Role;sensor;Signal Pathway;Signal Transduction;Skin;solute;Study models;System;Tissues;transcription factor;Translating;Tumor Necrosis Factor Receptor;vector control;vector transmission;Vector-transmitted infectious disease;Visualization;West Nile virus;Work;ZIKA

PROJECT_TITLE: From Drosophila Immunity to Anti-Inflammatories

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Ovarian cancer is a major public health issue and is often diagnosed in later stages, resulting in an increased risk of death. Extracellular vesicles are nanoscale particles that circulate throughout bodily fluids and are released by all cells, and their cargo may indicate early signs of ovarian cancer or inform better treatment strategies. The proposed training and research will create improved methods for characterizing and classifying extracellular vesicles to improve patient outcomes by developing ultrasensitive detection devices and machine learning analytical tools.

PI_NAMEs: HISEY, COLIN LEE (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: advanced disease;algorithm training;analytical tool;aptamer;Architecture;Bar Codes;Biochemical;Biological Assay;Biological Markers;Bioreactors;Body Fluids;Cancer Patient;cancer subtypes;Cell Culture Techniques;Cells;Cessation of life;Chemicals;Classification;classification algorithm;Clinical;clinical application;clinical translation;Column Chromatography;Communicable Diseases;Complementary Feeding;Data;data acquisition;Data Analytics;Data Set;Dependence;design;Detection;Development;Devices;Diagnosis;Diagnostic;Diagnostic Neoplasm Staging;Disease;disease classification;disease diagnosis;disease diagnostic;disorder subtype;electron beam lithography;Engineering;Etiology;experimental study;extracellular vesicles;Fatality rate;Fingerprint;generative adversarial network;Geometry;Goals;Gold;Health;Heterogeneity;Human;Image;improved;innovation;interest;Intervention;Label;Laboratories;Lateral;Lipids;Machine Learning;machine learning algorithm;machine learning classification;machine learning classifier;Malignant neoplasm of ovary;Malignant Neoplasms;Mentors;Methods;Microfluidic Microchips;Microfluidics;Molecular Biology;Molecular Sieve Chromatography;Monitor;mortality risk;multidisciplinary;nanofabrication;nanoparticle;nanoplasmonic;nanoscale;Nature;new technology;Optics;particle;Patient-Focused Outcomes;Patients;Pattern;Phase;Plasma;Population;Positioning Attribute;prevent;Process;Production;programs;Public Health;Raman Spectrum Analysis;rapid growth;Reproducibility;reproductive system disorder;Research;Resolution;Sampling;sensor;Serous;Signal Transduction;simulation;skills;Source;Spectrum Analysis;Staging;Sulfhydryl Compounds;Surface;Surface Antigens;Survival Rate;Symptoms;Techniques;Testing;tool;Training;Translating;Translations;treatment strategy;vesicular release;Woman

PROJECT_TITLE: Machine Learning-enabled Classification of Extracellular Vesicles Using Nanoplasmonic Microfluidics


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Estrogen;Physical Injury - Accidents and Adverse Effects

ORG_CITY: SALT LAKE CITY

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Shoulder tendon tears are a common cause of shoulder pain and disability and after surgery the repaired tendon often does not heal. In this pilot study, men with low sex hormone levels will be randomly assigned to receive sex hormone therapy or placebo pills while healing from tendon repair surgery in their shoulder. Sex hormone therapy increases sex hormone levels, and the investigators will test whether these increased sex hormone levels show promise in improving tendon healing and patient shoulder function and pain.

PI_NAMEs: CHALMERS, PETER  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Adverse effects;Aftercare;Age;aged;Agreement;Animals;Appearance;Biology;bone;Clinical;clinical care;Clinical Trials;Clomiphene;Clomiphene Citrate;Control Groups;cost;Data;disability;Double-Blind Method;Enrollment;Enthesopathies;Estradiol;Estrogen Receptors;Exogenous Hormone Therapy;experience;Failure;FDA approved;Feasibility Studies;Female;follow-up;Future;Gene Expression;gene repair;Genetic Polymorphism;Gonadal Steroid Hormones;Gonadotropins;healing;Healthcare Systems;Histologic;Hormonal;hormone deficiency;hormone therapy;Hormones;Human;human male;Hypogonadism;improved;Injury;insight;instrument;interdisciplinary approach;Intervention;Laboratory Finding;Magnetic Resonance Imaging;male;Measures;men;Mus;Musculoskeletal;novel;Operative Surgical Procedures;Outcome;Ovarian Hyperstimulation Syndrome;Pain;Patient Care;Patient Compliance;Patients;Persons;Pharmaceutical Preparations;phase 2 study;Physiological;pill;Pilot Projects;Placebo Control;Placebos;Postoperative Period;pre-clinical;Production;prospective;Prospective Studies;Questionnaires;Randomized;randomized trial;randomized, clinical trials;randomized, controlled study;receptor;recruit;repaired;Research;Research Personnel;Research Proposals;response;retention rate;Rotator Cuff;rotator cuff tear;Serum;Shoulder;Shoulder Pain;Side;side effect;soft tissue;Source;Standardization;success;Supplementation;Tendinopathy;Tendon structure;Testing;Testosterone;Time;Tissues;Translating;Visit;Withdrawal;Work

PROJECT_TITLE: Sex Hormone Supplementation and Rotator Cuff Repair: A Preliminary Randomized Trial

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC(10)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Family caregivers and home care aides interact to provide care for older adults living with Alzheimer’s Disease and Related Dementias (ADRD), but their relationship is often made difficult due to gaps in information, misalignment of role expectations, lack of shared understanding of each other’s roles in home care, and preferences regarding daily activities and routines. The goal of this proposal is to develop and refine a home care role and preference guide to improve information sharing between family caregivers of older adults living with ADRD and home care aides. The proposal will support the career development of Dr. Chanee Fabius who aims to conduct embedded pragmatic clinical trials (ePCTs) directed at testing interventions, policies and programs in real world settings to better support the home care workforce and improve care quality and quality of life among vulnerable older adults receiving services and their family caregivers.

PI_NAMEs: FABIUS, CHANEE  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: acceptability and feasibility;Address;Administrator;Adverse effects;Aging;Alzheimer's disease caregiver;Alzheimer's disease related dementia;American;Applications Grants;Area;Award;Basic Science;Behavior;Behavioral Model;care coordination;care delivery;care recipients;career;career development;Caregivers;Caring;Case Manager;Characteristics;Communication;Communities;community based service;community living;Data;Dementia;dementia care;design;Development;disability;Disease Progression;Disparity;Dual Enrollment;Enrollment;Exclusion;expectation;experience;Family;Family Caregiver;Feeling;Funding;Future;Goals;Health;health management;Health Policy;Home;Home Care Agencies;Home Health Aides;Home Nursing Care;Human;improved;Intervention;Interview;K-Series Research Career Programs;Knowledge;Learning;Maryland;Medicaid;Medicare/Medicaid;Mentorship;Methods;Nurses;older adult;Outcome;patient home care;Persons;Policies;Pragmatic clinical trial;preference;primary endpoint;Privatization;Process;professor;programs;Public Health Schools;Quality of Care;Quality of life;Recommendation;Reporting;Research;Research Personnel;Residential Treatment;Resources;Role;Sampling;service delivery;Services;skills;social engagement;Stress;symposium;Testing;therapy development;Time;Training;Translating;trend;United States National Institutes of Health;user centered design;Visit;Work

PROJECT_TITLE: Improving Information Sharing Between Family Caregivers and Home Care Aides Caring for Persons Living with ADRD

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE It is largely recognized that to best study and understand the health needs of a diverse population, it is important to have a diverse group of health scientists and researchers. However, many talented potential researchers fail to make it into biomedical research because they did not have access to adequate research opportunities in college. Here we propose a two-year post-baccalaureate program targeted at such individuals to help prepare them to enter and succeed in a biomedical research career.

PI_NAMEs: GRUEBER, WESLEY B (contact);HENGST, ULRICH

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Advisory Committees;Area;Attention;Bachelor's Degree;Basic Science;Behavior;Behavioral;Biomedical Research;career;career awareness;career development;career networking;Cognitive;cohort;college;Communication;Complement;computational neuroscience;Data;Dedications;Degree program;design;Development;Development Plans;Doctor of Philosophy;Doctor's Degree;early experience;Education;Educational workshop;effectiveness evaluation;Equilibrium;Equity;Ethnic Population;Evaluation;Event;experience;Experimental Designs;Faculty;Feedback;Fostering;Foundations;Goals;graduate school;graduate student;Health;high school;Human;Individual;Institution;interest;Journals;junior high school;Leadership;Learning;lectures;Left;Life;Literature;Lived experience;meetings;Mentors;Mentorship;Mission;Modeling;Molecular;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurobiology;Neurosciences;Neurosciences Research;New York City;outreach;Participant;Population;Population Heterogeneity;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;preference;Preparation;Program Effectiveness;programs;racial diversity;racial population;Readiness;Reading;Research;Research Personnel;Research Project Grants;role model;Science;Scientist;senior faculty;Series;skills;social;Structure;student mentoring;Students;success;support network;Surveys;symposium;synergism;System;Talents;Training;Travel;undergraduate student;Underrepresented Populations;Universities;Work;Writing

PROJECT_TITLE: CADRE Program for Postbaccalaureate Training in the Neurosciences


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Immunization;Immunotherapy;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project Narrative Schistosomiasis is a major tropical disease caused by parasitic flatworms called schistosomes (commonly known as blood flukes). Our aim in this project is to develop a new method to block the functions of essential worm surface enzymes as a novel treatment for infection.

PI_NAMEs: SHOEMAKER, CHARLES BIX;SKELLY, PATRICK J (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acetylcholinesterase;Ache;Adolescent;Affinity;Alpaca;Binding;Biochemical;bone;carbonate dehydratase;Chinese Hamster Ovary Cell;Chronic;Clinical Trials;Country;Data;Development;dimer;Disease;Drug Kinetics;Drug usage;Ensure;Enzymes;Family;Fc domain;Genetic Transcription;Goals;Hand;Helminths;Human;Immunize;immunogenicity;Immunotherapeutic agent;improved;In Vitro;in vivo;Infection;Infection Control;Infection prevention;innovation;Intervention;Laboratory Study;Libraries;Life;Link;Longevity;Lymphocyte;Messenger RNA;Methods;Molecular;Molecular Target;Mus;nanobodies;novel;novel therapeutics;Parasites;Persons;Phage Display;Pharmaceutical Preparations;phosphoric diester hydrolase;Platyhelminths;Praziquantel;Praziquantel resistance;prevent;Proteins;Publishing;pyrophosphatase;Reagent;Recombinants;response;RNA;RNA Interference;Schistosoma;Schistosoma mansoni;Schistosomatidae;Schistosomiasis;Series;Serum;success;Surface;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;therapeutic RNA;tool;Tropical Disease;Vaccines;World Health Organization

PROJECT_TITLE: RNA encoded nanobody-based immunotherapeutics targeting essential, host-interactive schistosome ectoenzymes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(83)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Endocrine Disruptors;Genetics;Neurosciences

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Atrazine is an agricultural herbicide widely used in the Midwestern United States. Atrazine is the most common contaminant of potable water supplies in the United States and is an endocrine disrupting chemical that targets the neuroendocrine and neurotransmitter systems. This study will investigate the kisspeptin system as the master regulator connecting adverse health outcomes observed following developmental atrazine exposure along the multiple endocrines axes and neurotransmission systems for translation to human health risk.

PI_NAMEs: FREEMAN, JENNIFER L. (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Address;Adrenal Glands;Adult;adverse birth outcomes;Agriculture;Animals;anxiety-related behavior;Atrazine;Behavior;behavioral outcome;Biological Models;Brain;carcinogenesis;Cell Cycle Regulation;Central Nervous System;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Development;developmental neurotoxicity;Disease;DNA Methylation;Dopamine;drinking water;Embryo;Embryonic Development;Endocrine;Endocrine disruption;Endocrine Disruptors;epidemiology study;Epigenetic Process;Follicle Stimulating Hormone;Follicular Atresia;Functional disorder;Future;Genes;Genetic;GNRH1 gene;Goals;Gonadotropin Hormone Releasing Hormone;Habenula;Health;Herbicides;hormonal signals;Hormones;Human;human model;Hypothalamic structure;Impairment;KISS1 gene;Knowledge;Laboratory Study;late life;Locomotion;Luteinizing Hormone;men;Menstrual cycle;MicroRNAs;Midwestern United States;Modeling;Modification;Molecular;mutant;neurobehavior;neurobehavioral;Neurologic;Neurons;Neuropeptides;Neurosecretory Systems;neurotoxicity;neurotransmission;Neurotransmitters;novel;Outcome;Ovarian;Pathway interactions;Peptides;Pituitary Gland;pituitary gonadal axis;Proteins;Reporting;Reproduction;reproductive;Reproductive system;Research;Risk;Rodent Model;Role;Seminal fluid;Serotonin;Source;Specificity;Steroids;Supplementation;System;Systems Development;Testing;Thyroid Gland;timeline;Toxic effect;toxicant;Transcript;transcriptomics;translation to humans;United States;Water;Water Pollutants;Water Supply;Woman;Work;Zebrafish

PROJECT_TITLE: Developmental neuroendocrine toxicity targeting the kisspeptin pathway

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Immunization;Vaccine Related

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: This is a new application for a T32 training program in vaccinology (vaccine science). There is a great need to train future generations of MD and PhD scientists in all aspects underlying the development of vaccines. This new training program builds on a strong legacy and ongoing commitment to vaccine development and evaluation at Cincinnati Children’s Hospital, and will meet this important need.

PI_NAMEs: FRENCK, ROBERT WILSON;SPEARMAN, PAUL W. (contact);WAY, SING SING

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: Training Programs;vaccinology

PROJECT_TITLE: Vaccinology Training Program

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orthopoxviruses;Prevention;Rare Diseases

PHR: Viruses related to smallpox continue to be a threat to global public health, especially because most people are no longer being vaccinated against smallpox. Here, we plan to study how infectious poxvirus particles are assembled and released from cells. We believe our work will provide new information that will aid in the development of new treatments for these viruses and in improving the ways in which harmless forms of these viruses can be used for cancer therapy.

PI_NAMEs: CHANDRAN, KARTIK  (contact)

PROGRAM_OFFICER_NAME: KNISELY, JANE M

PROJECT_TERMS: Actins;Amino Acids;Behavior assessment;Binding;Biochemical;Biological Assay;Biology;C-terminal;C-Type Lectins;cancer therapy;Cell surface;Cells;Collaborations;Complement;Complex;Cowpox virus;Cytoplasm;Cytoplasmic Tail;Data;Defect;Development;Dissection;extracellular;fitness;Gene Combinations;Generations;Genetic;Genetic Screening;Genetic study;genomic locus;GPA33 gene;Growth;Human;Immunity;improved;in vivo;Individual;Infection;Internet;Intracellular Membranes;Libraries;loss of function;Mammals;Mass Spectrum Analysis;Mediating;member;membrane assembly;membrane biogenesis;Membrane Proteins;Molecular;Monkeypox virus;Morphogenesis;Motility;Mutagenesis;mutant;Mutate;Mutation;mutation screening;Nature;new epidemic;next generation sequencing;novel;Oncolytic;oncolytic vector;Orthopoxvirus;particle;Persons;Phenotype;Point Mutation;Population;Poxviridae;poxvirus vectors;prevent;protein protein interaction;Proteins;Proteomics;prototype;Public Health;Reporting;reverse genetics;Risk;Role;Sensitivity and Specificity;Serial Passage;Series;Site;Smallpox;Surface;Therapeutic;Therapeutic antibodies;tissue tropism;transmission process;Vaccinated;Vaccination;Vaccines;Vaccinia virus;Viral;Viral Proteins;Virion;Virulence;Virus;virus genetics;virus host interaction;virus virus interaction;Work;Zoonoses

PROJECT_TITLE: Comprehensive genetic dissection of poxvirus membrane assembly and function


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative This proposal addresses a gap in our knowledge regarding the impact of cellular tropism of coronavirus such as SARS-CoV-2 on disease pathogenesis. We propose the generation of unique models in which infection of respiratory epithelia cells by virus is limited to specific cell populations, thus providing information regarding their contribution to COVID-19 like lung disease.

PI_NAMEs: KOLLER, BEVERLY H (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;ACE2;Acute Lung Injury;Address;Affect;airway epithelium;Alveolar;alveolar type II cell;apical membrane;Basal Cell;Biological Models;Breeding;cell type;Cells;Cellular Tropism;Cessation of life;clinically relevant;Cognitive;Coronavirus;COVID-19;COVID-19 monitoring;Cre driver;Development;Disease;Disease Progression;Distal;DNA cassette;Docking;Enterobacteria phage P1 Cre recombinase;Epithelial Cells;Epithelium;Event;Gases;Generations;Genes;Genomics;Goals;Goblet Cells;Health;Host Defense;Human;Immune response;in vivo Model;Individual;Infection;Initiator Codon;Knock-in;Knowledge;Lung;Lung Diseases;male;Mammalian Cell;model design;Modeling;mouse development;mouse model;Mus;Nasal Epithelium;Nature;novel coronavirus;pathogen;Pathogenesis;Pattern;Peptide Initiation Factors;Population;Predisposition;Prevalence;Production;Proliferating;promoter;protective pathway;pulmonary function;receptor;Receptor Cell;Research Personnel;Respiratory System;Respiratory Tract Infections;restoration;Role;SARS coronavirus;SARS-CoV-2 exposure;SARS-CoV-2 infection;Severity of illness;species difference;Structure;Study models;System;Therapeutic;Therapeutic Intervention;tissue tropism;Tissues;tool;Transgenic Mice;Transgenic Organisms;Tropism;Type II Epithelial Receptor Cell;vaccine development;Validation;Viral;Viral Pathogenesis;Virus;Virus Diseases;Virus Replication;virus tropism

PROJECT_TITLE: Modeling the contribution of coronavirus cellular tropism to viral pathogenesis

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Inflammatory Bowel Disease;Microbiome

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Enteric infections are a common cause of dysbiosis, and have been implicated as an environmental factor in onset and flare of IBD. Our preliminary data has identified enteric infection in nearly 30% of IBD flares, with the most common pathogens including Clostridioides difficile, Escherichia coli, and norovirus. This study will determine the clinical and molecular impact of specific enteric pathogens on the course of IBD to directly improve IBD outcomes and further elucidate mechanisms of pathogen-associated dysbiosis underlying chronic gastrointestinal inflammation.

PI_NAMEs: AXELRAD, JORDAN ERIC (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acute;Affect;American;Animal Model;antimicrobial;Biochemical;Biological Assay;Biometry;Biopsy;CD8B1 gene;Characteristics;Chronic;Clinical;clinical diagnosis;Clinical Management;Clostridium difficile;cohort;Complex;Crohn's disease;Data;Development;Disease;Disease Outcome;Disease Progression;Disease remission;disorder risk;dysbiosis;enteric infection;enteric pathogen;enteropathogenic Escherichia coli;Environment;Environmental Risk Factor;Escherichia coli;Evaluation;Feces;Flare;Frequencies;Funding;Gastroenteritis;gastrointestinal;gastrointestinal infection;Gastrointestinal tract structure;Goals;gut inflammation;gut microbiome;Helper-Inducer T-Lymphocyte;high risk;Hospitalization;Immune;Immune response;Immunologic Factors;Immunology;Immunosuppression;improved;Individual;Infection;infection management;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;Intervention;Intestinal Mucosa;Knowledge;Lamina Propria;longitudinal analysis;Mentors;Methods;microbial;Microbiology;Molecular;molecular subtypes;Mucosal Immunity;Mucous Membrane;multidisciplinary;Norovirus;novel;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Outcome;outcome prediction;pathogen;patient oriented;Patient-Focused Outcomes;Patients;personalized approach;polarized cell;Polymerase Chain Reaction;population based;Positioning Attribute;profiles in patients;prospective;Quality of life;radiological imaging;recruit;Recurrence;Recurrent disease;Relapse;Research;Risk;Role;rRNA Genes;Salmonella;Severities;single-cell RNA sequencing;Technology;Testing;Therapeutic;Training;translational scientist;Ulcerative Colitis

PROJECT_TITLE: The Role of Enteric Infection in Flares of Inflammatory Bowel Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: SURGERY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Pancreatic ductal adenocarcinoma (PDA) is characterized by extensive desmoplasia caused by different cancer-associated fibroblast (CAF) populations. As a major source of fibroblasts in other pathological conditions such as wound healing, peritoneal fibrosis and surgical adhesions, mesothelial cells have been historically neglected as a potential functional constituent of the PDA microenvironment. This project aims to investigate the contribution of mesothelial cells to CAF formation and the function of mesothelial-fibroblastic transition in PDA, which will elucidate a novel mesothelial cell-CAF system and has the potential to result in the identification of novel strategies to target CAFs in PDA.

PI_NAMEs: HUANG, HUOCONG  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Address;Adhesions;anti-cancer;Antibody-drug conjugates;Antigen Presentation;cancer cell;CD4 Positive T Lymphocytes;Cells;chemotherapy;chimeric antigen receptor T cells;Clinical;combat;Cues;Data;Disease;Drug Delivery Systems;Embryo;Epithelial Cells;Exclusion;Extracellular Matrix;Fibroblasts;Fibrosis;Genes;immune checkpoint blockade;Immune Evasion;immune resistance;Immunosuppression;Immunotherapy;Impairment;In Vitro;in vivo Model;Inflammatory;Interleukin-1;Invaded;lipid biosynthesis;Malignant Neoplasms;Membrane;Mesenchymal;Mesoderm;Mesothelial Cell;mesothelin;Mesothelium;Monoclonal Antibodies;mouse genetics;Myocardial Infarction;neglect;novel;novel strategies;Operative Surgical Procedures;Organ;Outcome;Pancreatic Ductal Adenocarcinoma;Pathologic;Peripheral;Peritoneal;Phase;Phenotype;Physiological;Population;Preclinical Testing;prevent;Process;Reporting;Resistance;Signal Pathway;single-cell RNA sequencing;Solid Neoplasm;Source;Surface;Survival Rate;System;T cell infiltration;T cell regulation;T-Cell Activation;T-Lymphocyte;targeted cancer therapy;Testing;Tissues;Training;Transforming Growth Factor beta;tumor;tumor microenvironment;tumor progression;Tumor Volume;tumor-immune system interactions;Vaccines;wound healing

PROJECT_TITLE: Function of mesothelial cells in the tumor microenvironment of pancreatic ductal adenocarcinoma


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

PHR: Surveillance of Modifiable Social Determinants of Health for Prioritizing Wraparound Supports 60% of Veterans in Veterans Treatment Courts (VTCs) have a co-occurring mental health and opioid use disorder (OUD), thereafter called COD. Those Veterans are at risk for opioid overdose (OOD) but have less engagement of medications for OUD (MOUD) and other OUD treatments than other Veterans, resulting in unemployment and homelessness - predictors of reoffending. Many Veterans in VTCs, particularly those with an OUD have multiple social determinants of health (SDOH) issues that need to be addressed simultaneously. In this application, we will develop and test SoS-MISSION, a dashboard which flags unmet social needs of justice-involved Veterans at high risk of MOUD discontinuation and OOD.

PI_NAMEs: SMELSON, DAVID A;YU, HONG  (contact)

PROJECT_TERMS: addiction;Address;Afghanistan;Appearance;Assertiveness;Behavior;behavioral health;care systems;Client;Collaborations;Combined Modality Therapy;Community Services;Consensus;court;Criminal Justice;Crowding;dashboard;Data;design;Development;Drug Controls;Electronic Health Record;electronic structure;empowerment;Financial Hardship;food insecurity;Funding;handbook;high risk;Homelessness;Housing;implementation cost;implementation study;Imprisonment;improved;innovation;International Classification of Disease Codes;Iraq;Justice;Knowledge;Legal;medication for opioid use disorder;Mental Health;Mental Health Services;Methodology;Modeling;multi-component intervention;Natural Language Processing;Occupations;opioid overdose;opioid use disorder;outreach;outreach program;overdose risk;Pain;Patients;Physicians;Prisons;programs;Provider;psychosocial;Recovery;Research;Risk;Risk Factors;Services;Site;sobriety;social;social health determinants;Social isolation;Structure;structured data;Subgroup;Substance Use Disorder;suicidal risk;Suicide attempt;suicide mortality;Surveys;System;Systems Integration;Technology;Testing;Time;Transportation;Unemployment;uptake;Veterans;Work

STUDY_SECTION_NAME: HSR-3 Healthcare Informatics[HSR3]


ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: PA

PHR: Family caregivers frequently provide transfer assistance to Veterans with mobility impairments to facilitate the completion of essential daily tasks like bathing, toileting, and getting in/out of bed. However, assisted transfers are known to be one of the most strenuous activities leading to back and shoulder pain and injury to the caregiver and potential harm to the Veteran if not performed correctly. Recently, a tool called the Caregiver Assisted Transfer Technique Instrument (CATT) was developed to assess the quality of the transfer techniques used by informal caregivers. The tool is designed to identify deficits in technique that if corrected could reduce the risk of injuries to both the caregiver and their care recipients. The goal of this project is to determine the reliability and validity of the CATT and test its ability to improve the transfer technique of caregivers when used as an assessment and training tool.

PI_NAMEs: KOONTZ, ALICIA M. (contact)

PROJECT_TERMS: Activities of Daily Living;Adult;Affect;Age;American;Area;Assessment tool;Awareness;Back Pain;Bathing;Beds;biomechanical test;Biomechanics;body mechanics;care recipients;caregiver education;Caregivers;caregiving;Caring;Characteristics;Chronic;Client;Clinical;Contusions;Data;Demographic Survey;design;disability;Disabled Persons;Educational Intervention;Educational Status;Enrollment;experience;falls;Family Caregiver;Goals;hazard;Health;Health Status;high risk;Hip Fractures;Hip region structure;Home;improved;Income;Individual;Individuals with physical disabilities;informal caregiver;Injury;instrument;intervention participants;Knee;Lifting;Manuals;Measurement;Measures;Mechanics;Mobility decline;Modeling;Musculoskeletal;musculoskeletal injury;Musculoskeletal Pain;Neck Pain;Outcome Measure;Pain;Participant;Performance;Persons;physically handicapped;Practice Guidelines;pressure;Process;Property;Protocols documentation;Psychometrics;recruit;Rehabilitation therapy;Reporting;Research;Review Literature;Risk;Risk Reduction;Rotation;Series;Services;shoulder injury;Shoulder Pain;skills;Skin;Slide;sound;standard of care;Strenuous Exercise;Surface;Surveys;Task Performances;Techniques;Technology;Testing;tool;Training;Training and Education;Validation;Validity and Reliability;Veterans;Visit;Work

PROJECT_TITLE: Biomechanical validation of the Caregiver Assisted Transfer Technique Instrument

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


PHR: Amputation is one of the most cited injuries of recent conflicts, and the technology of advanced prosthetics have received substantial attention. Prosthetic arms are often uncomfortable which is generally attributable to the fit and comfort of sockets and harnesses and are not worn primarily for this reason. This project is focused on an innovative new transradial socket textile-based design inspired by advanced athletic shoe technology. This study will improve upon and investigate the validity of an innovative new transradial socket and harness design with a hybrid polymer and textile-based design derived from advanced athletic shoe technology. The system creates a dynamic and secure attachment with a combination of two lacing systems. These lacing systems lengthen and shorten flexible hinges at the elbow, maintaining a secure attachment throughout the range of motion and accounting for volume changes.

PI_NAMEs: COOPER, RORY A. (contact);KOONTZ, ALICIA M.

PROJECT_TITLE: The Advancement of a New Variable-Compliance Socket and Frame System forTransradial Amputees to Optimize Socket Fit and Upper Limb Function

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


ORG_CITY: ANN ARBOR

ORG_STATE: MI

PHR: The proposed research is relevant to the health of Veterans by accelerating our understanding and the evidence-basis for measuring the overall value of emergency department care, an essential and frequent care setting for Veterans. Once these innovative strategies have been developed and tested, they then can be implemented within the Veterans Affairs health care system to systematically reveal opportunities for improvement and spotlight high value targets of intervention to maximize the quality and safety of emergency department practices.

PI_NAMEs: KOCHER, KEITH ERIC (contact);VASHI, ANITA A

PROJECT_TERMS: Acceleration;Accident and Emergency department;Acute;acute care;Address;Adoption;Ambulatory Care;Budgets;care delivery;care episode;care fragmentation;care providers;Caring;Categories;Chest Pain;Chronic Obstructive Pulmonary Disease;cohort;Communities;community based care;Community Healthcare;Community Hospitals;community setting;Congestive Heart Failure;cost;dashboard;Data;Data Mart;Diagnosis;Emergency Care;Emergency department visit;Emergency Situation;Event;Exclusion;Exclusion Criteria;experience;follow-up;Goals;Health;health care delivery;Health system;Healthcare Systems;hospital readmission;Hospitalization;Hospitals;Impairment;Improve Access;improved;inclusion criteria;indexing;Individual;innovation;Inpatients;insight;interest;Intervention;Knowledge;lens;Link;Location;Measures;Medicare;Methodology;Methods;Modeling;mortality;Outcome;Outpatients;Patients;Pattern;payment;Pneumonia;Population;Positioning Attribute;preference;Provider;Research;Resources;Risk Adjustment;Role;Safety;Science;Services;Source;Standardization;successful intervention;suicidal;System;Testing;United States Centers for Medicare and Medicaid Services;United States Department of Veterans Affairs;Variant;Veterans;Veterans Health Administration;Visit

PROJECT_TITLE: Improving Value through Comprehensive Episodes of Emergency Care for Veterans

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


PHR: Obstructive Sleep Apnea (OSA) is common in military Veterans, who may not completely to treatment with Positive Airway Pressure (PAP) and experience persistent sleepiness and depression. A growing body of literature in animal and human models suggests that the sleep and respiratory disturbances commonly seen in OSA, can promote shifts in circadian rhythms ultimately leading to misalignment between sleep-wake rhythms and the internal clock. Targeting the circadian disturbance with chronotherapeutic interventions, such as Bright Light Therapy, may improve symptoms that most affect daily functioning andquality of life, ultimately preventing the downstream effects of OSA leading to disability. Our study is the first to use bright light therapy to improve sleep related functioning by reducing the residual daytime symptoms most strongly linked to disability in patients with sleep apnea

PI_NAMEs: SORECA, ISABELLA  (contact)

PROJECT_TERMS: active method;Affect;affective disturbance;alertness;Animal Model;Anxiety Disorders;Arousal;associated symptom;Biological Clocks;Biological Markers;Brain;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Consumption;Continuous Positive Airway Pressure;cost;Cross-Over Studies;Cross-Over Trials;Cues;daily functioning;Depressive disorder;Diagnosis;disability;Disease;Drowsiness;Excessive Daytime Sleepiness;experience;Exposure to;Fatigue;feasibility testing;Functional impairment;Healthcare;Hour;human model;Hypoxia;Impairment;improved;improvement on sleep;interest;Intervention;Intervention Trial;Knowledge;Legal patent;Light;Link;Literature;Mediating;Melatonin;Mental Depression;Metabolism;military veteran;Moods;neuropsychiatry;Obstructive Sleep Apnea;Organism;Participant;Pathogenesis;Patients;Peripheral;Phase;Phototherapy;Pilot Projects;Placebos;poor sleep;Population;positive airway pressure;Premature Mortality;Prevalence;prevent;Quality of life;Residual state;Resistance;Resolution;Resources;respiratory;response;Risk;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;Sleep Wake Cycle;symptomatic improvement;Symptoms;Testing;Time;time interval;treatment response;Veterans;vigilance;Wakefulness

PROJECT_TITLE: Bright Light Therapy for residual daytime symptoms associated with obstructive sleep apnea

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The Equity in Maternal and Birthing outcomes and Reproductive HeAlth through Community Engagement (EMBRACE) Center of Excellence seeks to advance reproductive health and justice for Black populations in Allegheny County, Pennsylvania via multidisciplinary, community-centered research and training. Academic partners, practitioners and community leaders will work together to implement three multi-level research projects, supported and structured by components that prioritize community ownership, data transparency, and anti- oppression praxis. The intervention and implementation research generated from EMBRACE will address key factors related to maternal morbidity and mortality across the reproductive span among Black populations. Finally, EMBRACE will also set in motion necessary and sustainable improvements in academic-community partnerships, social services and health and health policy in our region.

PI_NAMEs: MENDEZ, DARA DANEEN (contact);SIMHAN, HYAGRIV N;TALABI, MEHRET BIRRU

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: abortion;Address;adverse outcome;Advocate;anti-racism;Area;Arts;behavior change;Behavioral;Birth;Black Populations;Black race;black women;Cardiovascular system;care providers;career;Caring;Child;Clinical;Collaborations;Communication;Communities;community academic partnership;community empowerment;community engaged research;community engagement;Community Health Aides;community partners;community partnership;community-centered;Contraceptive methods;County;Data;data access;data hub;Death Rate;design;Discipline of Nursing;Education;Employment Opportunities;Ensure;Environmental Exposure;Equity;Family;Family health status;Federally Qualified Health Center;Freedom;Gender;Gender expansive;Geography;healing;Health;health equity;health inequalities;Health Personnel;Health Policy;Healthcare;Home Blood Pressure Monitoring;Housing;implementation research;improved;Individual;Inequity;Infant Mortality;innovation;Institution;Institutional Racism;Interdisciplinary Study;Intervention;Intervention Studies;Justice;Knowledge;Leadership;Lived experience;Maternal Health;Maternal Health Services;maternal morbidity;Maternal Mortality;Medicaid;Medicine;Mental Health;Methods;Midwife;Modeling;Morbidity - disease rate;mortality;Motion;multidisciplinary;Outcome;Ownership;Parents;Pathway interactions;Pennsylvania;perinatal health;Personal Satisfaction;Persons;Phase;Policies;Policy Analysis;Population;Populations at Risk;Postpartum Period;Pregnancy;pregnant;prevent;Process;programs;prospective;Public Health;Public Health Schools;Race;racial disparity;Racial Equity;racism;Recording of previous events;reproductive;Reproductive Health;Reproductive Health Services;Research;Research Design;Research Institute;Research Personnel;Research Project Grants;Research Support;Risk;Scholarship;Science;severe maternal morbidity;Shapes;social factors;social health determinants;Social Justice;Social Work;socioeconomic disparity;Specific qualifier value;Stress;structural determinants;Structural Racism;Structure;success;supportive environment;synergism;therapy design;Training;Training Activity;Training and Education;Translating;treatment as usual;trial comparing;two-arm trial;Vision;Voice;Woman;Work;working group

PROJECT_TITLE: Equity in Maternal and Birthing Outcomes and Reproductive HeAlth through Community Engagement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-F (71)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: Narrative In this proposal, we seek to develop an innovative model of postpartum care for Black birthing people, a group with exceptionally high rates of severe maternal morbidity and maternal mortality because of structural and interpersonal racism, social determinants of health, and inadequate health care delivery. We will leverage community and training resources from the Equity in Birth Outcomes and Reproductive Health Through Community Engagement Center (EMBRACE) to develop and implement a new, integrative model of postpartum care that is culturally- and community-informed. We hypothesize that this new model of postpartum care will reduce severe maternal morbidity and maternal mortality and enhance health outcomes and well- being among Black birthing people.

PI_NAMEs: BARTLETT, STACY  (contact)

PROJECT_TERMS: Acute;acute stress;American;American College of Obstetricians and Gynecologists;anti-racism;Behavior;behavioral health;Birth;Black Populations;Black race;black women;Caring;Cities;Client;Clinic;Clinic Visits;Clinical;clinical care;clinical center;college;Communities;community engagement;community partners;County;Data;Developed Countries;Development;Equity;experience;Family Leave;Family Planning;Family Practice;Feedback;Focus Groups;fourth trimester;Funding;Goals;Health;health care delivery;health inequalities;Health Personnel;Health system;health training;Healthcare;Healthcare Systems;implementation outcomes;improved;Individual;Infant;innovation;Institutional Racism;Intervention;Interview;Justice;Knowledge;Low income;Maternal Health;Maternal Mortality;maternal outcome;Medical;Methods;Midwifery;Modeling;Morbidity - disease rate;mortality;multidisciplinary;novel;Nurses;Outcome;perinatal health;perinatal outcomes;person centered;Personal Satisfaction;Persons;Physical Examination;Physicians;postpartum care;postpartum health;Postpartum Period;Pregnancy;pregnancy related death;prevent;Process;Qualitative Research;racial disparity;racism;Recommendation;reproductive;Reproductive Health;Research;Research Methodology;Residencies;Resources;Risk Factors;satisfaction;screening;Service delivery model;severe maternal morbidity;Signal Transduction;Signs and Symptoms;Site;social health determinants;stressor;Structural Racism;Training;United States;uptake;Visit;Vulnerable Populations;Well Child Visits;White Women;women's reproductive health;Work

PROJECT_TITLE: Developing Autonomy-Centered models of 4th Trimester and Interconception care: Project 3


NIH_SPENDING_CATS: Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE The Community Component of the EMBRACE (Equity in Maternal and Birthing Outcomes and Reproductive Health through Community Engagement) Center of Excellence will leverage existing networks to advance coordinated efforts of research and community agencies that are invested in maternal and child health through a strengths-based community-centered engagement strategy to promote bi-directional and process-driven learning, research, education, and training. The Community Component will work closely alongside EMBRACE Research Projects and Training Component to ensure equal and equitable practices through intentional integration of interdisciplinary community collaborators in all aspects of the research lifecycle; training and education opportunities; knowledge generation and skill-sharing; and dissemination and implementation of research findings. The Community Component will serve as trusted hub within EMBRACE for individuals and agencies to build community, capacity, and infrastructure for advancing Black maternal and child health and eliminating racial maternal health disparities in Allegheny County.

PI_NAMEs: HILL, ASHLEY  (contact)

PROJECT_TERMS: Address;Adverse event;Advocate;Area;Award;Birth;Black race;black women;Caring;Childbirth;Cities;Collaborations;Communities;community building;community engaged approach;community engaged research;community engagement;Community Integration;community partners;community-centered;County;Data;Data Collection;Decision Making;Discipline;Disparity;Dissemination and Implementation;Education;Elements;Ensure;Epidemiology;Equity;Exclusion;Feedback;Fostering;Generations;Health;health disparity;health equity;Health Sciences;improved;Individual;Inequity;infant morbidity/mortality;Infrastructure;Institution;Interdisciplinary Study;Investments;Justice;Knowledge;Lead;Learning;Life Cycle Stages;Location;Maternal and Child Health;Maternal Health;maternal morbidity;Maternal Mortality;member;Midwife;Minority Women;Morbidity - disease rate;mortality;Neighborhoods;Outcome;Perinatal;Persons;Pregnancy;preventable death;Process;professor;Psychology;Race;racial disparity;Recording of previous events;Reporting;reproductive;Reproductive Health;reproductive outcome;Research;Research Personnel;Research Project Grants;research study;Research Training;Resources;Scholarship;Science;Scientist;Service provision;skills;social determinants;Social Work;structural determinants;Training;Training and Education;Trust;Universities;Voice;Women's Health;Work

PROJECT_TITLE: Community and Stakeholder Partnerships


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

PHR: Training Component Narrative The overall goals of the Equity in Maternal and Birthing outcomes and Reproductive Health through Community Engagement (EMBRACE) Center training, capacity building, and education program are to: 1) support training and professional development of community- partnered reproductive and perinatal health researchers; and 2) build and provide high quality training for a community-informed care and public health practice workforce focused on reproductive and perinatal health equity and elimination of health disparities. The training program will serve as a backbone of the EMBRACE Center's thematic focus to improve maternal and reproductive health for Black populations.

PI_NAMEs: HAGGERTY, CATHERINE L (contact)

PROJECT_TERMS: Advocate;African;anti-racism;Area;Behavioral;behavioral and social science;Birth;Black Populations;Black race;Board Certification;Breast Feeding;career;career development;Caring;Certification;Child health equity;Childbirth;Clinical;Communication;Communities;Community Developments;community engaged research;community engagement;Community Health;Community Integration;Community Outreach;community partners;community setting;community-centered;Data;Data Scientist;Discipline;Discipline of Nursing;Discipline of obstetrics;Doctor of Philosophy;doctoral student;early-career faculty;Education;Educational Intervention;Educational process of instructing;Empathy;Environment;Equity;Exclusion;experience;Faculty;faculty mentor;Family Practice;Funding;Goals;health disparity;health equity;Health equity research;Health Personnel;Health Sciences;Humanities;improved;Infant Health;Institution;interest;International;Justice;Lactation consultant;Lead;Maternal and Child Health;Maternal Health;Medicine;member;mentoring community;Mentors;Mentorship;Morbidity - disease rate;mortality;Mothers;multidisciplinary;next generation;Outcome;Pediatric epidemiology;Pediatrics;Perinatal;Perinatal Epidemiology;perinatal health;Persons;Policies;Population;Postdoctoral Fellow;pre-doctoral;Pregnancy Rate;Privatization;professor;programs;Public Health;Public Health Practice;Public Health Schools;reproductive;Reproductive Health;Research;Research Personnel;Scientist;Services;Structure;success;symposium;Training;Training Activity;Training and Education;Training Programs;Training Support;Travel;undergraduate student;Vertebral column;Work

PROJECT_TITLE: Training and Education


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Peripheral nerve damage is a debilitating consequence of injury to the extremities of soldiers, long term consequences of which significantly impact Veterans, their caregivers, and the Veteran Healthcare System. In addition to loss of sensory and motor function, a particularly insidious and unsolved long-term consequence associated with nerve injury is a reduction in the structural integrity and strength of bone; this can increase risk of fracture as well as impact whole-body homeostasis. In this proposal, towards improved preservation and restoration of bone health following nerve injury, we propose to apply innovative magnetic resonance imaging (MRI) approaches to examine several structural and physiological properties of bone following nerve injury, nerve repair, and rehabilitative intervention.

PI_NAMEs: SHAH, SAMEER B. (contact)

PROJECT_TERMS: Acute;Address;Biological;Blood Vessels;bone;Bone Density;bone health;bone imaging;Bone Marrow;Bone remodeling;bone strength;Bone structure;bone turnover;Caregivers;Chronic;Clinical;clinical practice;Collagen;cortical bone;Coupling;Denervation;density;design;Deterioration;Diffusion;Dual-Energy X-Ray Absorptiometry;effectiveness evaluation;Exercise;Fracture;fracture risk;Functional disorder;functional improvement;Goals;Healthcare Systems;Hematopoiesis;Homeostasis;iatrogenic injury;Image;imaging approach;Imaging Techniques;Immune System Diseases;improved;Injury;injury and repair;innovation;Intervention;limb injury;long-term sequelae;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Marrow;Measures;mechanical properties;Minerals;Modeling;Morphology;Motor;motor disorder;motor impairment;Muscle;Muscle function;muscular structure;nerve damage;nerve injury;nerve repair;nerve supply;neurovascular;novel;Operative Surgical Procedures;Outcome;Outcome Study;Pain;Pathway interactions;peripheral nerve damage;Physiological;Porosity;preservation;primary outcome;Property;Protocols documentation;Quality of life;Recovery;Recovery of Function;Regulation;Rehabilitation therapy;reinnervation;repaired;restoration;Roentgen Rays;secondary outcome;Sensory;Soldier;Spinal cord injury;standard of care;Structure;substantia spongiosa;Techniques;Therapeutic;Thick;Time;Tissues;Traumatic injury;treadmill;Veterans;Water;X-Ray Computed Tomography

PROJECT_TITLE: Imaging Strategies to Evaluate Bone Health After Nerve Injury Repair and Rehabilitation


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Epigenomics is the study of reversible genomic modification and organization, and how these processes control gene expression, variation and phenotypic programming. These modifications impact human health and disease, and research to understand their impact is necessarily a highly interdisciplinary endeavor. This workshop will enhance training of the biomedical research workforce by providing early stage researchers with a broad, integrated understanding of epigenomic technologies and software, and enabling them to address innovative, interdisciplinary questions.

PI_NAMEs: POSPISILIK, JOHN ANDREW (contact)

PROGRAM_OFFICER_NAME: HERNANDEZ-RAMON, ELENA ESTELA

PROJECT_TITLE: Epigenomics Workshop for Graduate Students

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Nutrition;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: NARRATIVE Smoking remains the leading cause of preventable morbidity and mortality in the United States, with tobacco use accounting for more deaths each year than the combined deaths attributable to alcohol, other drugs, homicide, suicide, motor vehicle accidents, and sexual behavior. Efficiently connecting underserved smokers with limited resources to efficacious tobacco cessation programs is crucial for disease prevention and the elimination of health disparities. This study seeks to address this need through partnering with a large social service network, the Regional Food Bank of Oklahoma, to evaluate the efficacy and economic impact of a theoretically-based, fully automated, interactive smartphone-based smoking cessation intervention.

PI_NAMEs: VIDRINE, DAMON J. (contact);VIDRINE, JENNIFER IRVIN

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: Accounting;Address;Adult;alcohol and other drug;attributable mortality;Behavioral;Biochemical;Cancer Center;Cellular Phone;Cessation of life;Charities;Chronic lung disease;Client;Clip;Communities;Community Networks;community organizations;cost;Cost Analysis;cost effective;cost effectiveness;County;Data;design;Development;Disease;disorder prevention;economic evaluation;economic impact;efficacy evaluation;Enrollment;Evaluation;evidence base;experience;follow up assessment;Food;Goals;Health Care Visit;health disparity;Health Personnel;Health Resources;Health Services Accessibility;Health system;Healthcare Systems;Homicide;Hunger;improved;Incidence;Individual;Intervention;Link;low socioeconomic status;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;mHealth;mobile application;Morbidity - disease rate;mortality;Motivation;Myocardial Infarction;negative affect;nicotine replacement;Oklahoma;Participant;Pilot Projects;Population;Prevalence;programs;Proliferating;Public Health;quitline;Randomized;Research Personnel;Resource Sharing;Resources;Risk;Risk Factors;safety net;Series;Sex Behavior;Site;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;smoking prevalence;social disparities;Social Work;Socioeconomic Status;standard care;Stress;Stroke;Suicide;Tablets;Text;Text Messaging;Tobacco;tobacco cessation intervention;tobacco control;Tobacco use;Tobacco Use Cessation;treatment comparison;Treatment Efficacy;treatment group;Underserved Population;United States;vehicular accident;web portal;Work

PROJECT_TITLE: Partnering with a State Food Bank to Provide Tobacco Treatment to Underserved Smokers


NIH_SPENDING_CATS: Genetics

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE This study will mechanistically determine how a group of novel regulators, long “noncoding” RNAs, control mammalian cell differentiation through RNAs and small polypeptides they encode.

PI_NAMEs: HU, WENQIAN  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Amino Acids;Anti-sense RNA;Area;Automated Annotation;Biological Process;Biology;Categories;Cell Differentiation process;Cell Maturation;Cell Nucleus;Cell Size;cell type;Cells;Chromatin;Classification;Code;Collaborations;Computational algorithm;Confusion;diagnostic biomarker;differential expression;Discrimination;Disease;DLEU2 gene;Erythrocytes;Erythroid Cells;erythroid differentiation;experimental study;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genomics;Goals;Homologous Gene;Human;human disease;In Vitro;Inflammatory;Inflammatory Response;Inhibition of Apoptosis;insight;Knockout Mice;Knowledge;leukemia;loss of function;Macrophage;Malignant Neoplasms;Mammalian Cell;Mediating;Messenger RNA;Methods;Modeling;Molecular;Molecular Biology;mouse model;Mus;novel;Nuclear;Open Reading Frames;Pathologic;Physical condensation;Physiological;Play;polypeptide;Process;Proteins;Regulator Genes;ribosome profiling;Ribosomes;RNA;Role;Specificity;stem cells;System;Tertiary Protein Structure;therapeutic target;tool;Transcript;transcriptomics;Untranslated RNA;Work

PROJECT_TITLE: Molecular mechanistic studies of long “noncoding” RNAs in mammalian cell differentiation

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE This proposal examines the neural basis for how organisms make decisions about movements. Understanding neural activity in specific types of neurons under normal conditions, and how it is altered under pathological conditions, can contribute to improving treatments for movement disorders like Parkinson's disease.

PI_NAMEs: FELSEN, GIDON S (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Anatomy;Animal Model;Animals;awake;Behavior;Behavioral;Brain;Brain region;cell type;Characteristics;Choice Behavior;Cognitive;Contralateral;Cues;Data;Decision Making;Distal;experimental study;Funding;Goals;Human;improved;Intrinsic drive;Knowledge;Left;Link;Maps;Mediating;Midbrain structure;Modeling;Motor;Motor Neurons;Motor output;mouse model;Movement;Movement Disorders;Mus;Nervous System Physiology;neural;neural circuit;Neurons;Neurosciences;Odors;Organism;Outcome;Parkinson Disease;Pathologic;Physiological;Population;Positioning Attribute;Recording of previous events;Research;Rewards;Sensory;Series;Shapes;Site;Slice;Stimulus;Structure;superior colliculus Corpora quadrigemina;System;Testing;Work

PROJECT_TITLE: Functional neural circuitry for decision making in the superior colliculus

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Immunization

ORG_CITY: BINGHAMTON

ORG_DEPT: CHEMISTRY

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: Project Narrative: There is a rapidly growing interest in antibody-mediated drug delivery of immune stimulating payloads for the treatment of cancer. However, to-date these conjugates have been plagued by a high incidence of anti-drug antibodies (ADAs) that have prevented their clinical applications. The goal of this proposal is to demonstrate that our recently published Q295 conjugation technology reduces Fc-gamma uptake in antigen presenting cells (APCs) and masks the payloads from binding to ADAs by hiding them in a sterically occluded hydrophobic pocket in the Fc domain.

PI_NAMEs: BENJAMIN, SAMANTHA RENE (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Achievement;Affect;Affinity;Agonist;Allergic Reaction;Antibodies;antibody conjugate;Antibody Response;Antibody-drug conjugates;Antigen-Presenting Cells;Area;Attenuated;Binding;Biological;Biological Assay;biophysical tools;cancer therapy;CD80 gene;CD86 gene;Cells;clinical application;Cysteine;cytotoxic;Data;design;Development;Differentiation Antigens;Dose;drug clearance;Drug Delivery Systems;Engineering;Enzyme-Linked Immunosorbent Assay;Enzymes;Exhibits;experimental study;Fc domain;FDA approved;Fluorescence;Fluorine;Funding;glycosylation;Goals;Hydrophobicity;IgG1;imaging system;Immune;immunogenicity;Immunologic Adjuvants;Immunologic Stimulation;Immunooncology;Incidence;interest;live cell imaging;Location;Macrophage;Masks;Measurable;Mediating;Methods;Modeling;Molecular Conformation;Mus;Oregon;Oregon Green 488 carboxylic acid;Patients;Peptides;Pharmaceutical Preparations;Positioning Attribute;prevent;Proteins;Publishing;Reaction;Reporting;Risk;Sampling;Site;Technology;Therapeutic;TLR7 gene;tool;tumor;Tumor Tissue;United States National Institutes of Health;uptake;Visualization

PROJECT_TITLE: Mitigating ADA Through Site-specific Conjugation Technology


NIH_SPENDING_CATS: Chronic Pain;Digestive Diseases;Neurosciences;Pain Research;Urologic Diseases

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE  Cross-organ sensitization is a common occurrence in patients and animals with bowel dysfunction. Glial cells are important players in sensory neuron sensitization and cross-activation. TrkB.T1 has a specific role in satellite glial cells of dorsal root ganglia to regulate sensory cross-activation and cross-organ sensitization.

PI_NAMEs: QIAO, LIYA  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Adverse effects;Afferent Neurons;Affinity;Affinity Chromatography;Animal Model;Animals;Axon;Bladder;Blood - brain barrier anatomy;Brain-Derived Neurotrophic Factor;Calcitonin Gene-Related Peptide;Calcium;Cells;Central Nervous System;central sensitization;Chief Cell;clinically relevant;Clozapine;Coculture Techniques;Colon;comorbidity;Data;designer receptors exclusively activated by designer drugs;Development;Disease;Event;experience;experimental study;Functional disorder;Ganglia;Gender;Generations;Genetic;Genetic Transcription;Genotype;glial activation;Goals;Human;Hyperactivity;Hypersensitivity;In Vitro;in vivo;Inflammation;Inflammatory Bowel Diseases;insight;Intestines;Ion Channel;Irritable Bowel Syndrome;Measures;Mechanics;Mediating;Mediator;Messenger RNA;Modality;Molecular;Mus;N-Methyl-D-Aspartate Receptors;Nerve;neurochemistry;Neuroglia;Neurons;Neuropeptides;Neurotrophic Tyrosine Kinase Receptor Type 2;novel;Organ;Oxides;Pain;pain processing;paracrine;Pathway interactions;Patients;Peripheral;Permeability;Pharmaceutical Preparations;Process;Proteins;Proteolipids;Proteomics;Regulation;remote location;Role;screening;Sensory;sexual dimorphism;side effect;Spinal;Spinal Cord;Spinal Ganglia;System;Testing;therapeutic development;therapeutic target;Tissues;Visceral

PROJECT_TITLE: Sensory Cross-Activation in Bowel Dysfunction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


ORG_CITY: PROVIDENCE

ORG_DEPT: PATHOLOGY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Cancer is caused by DNA mutations, however, many lung cancer-causing chemicals do not directly damage DNA and are frequently tested as weak mutagens. This project will investigate a novel process through which a nonmutagenic metal nickel can produce cancer-promoting genetic damage. A completion of the proposed work will improve our understanding how a seemingly genetically harmless chemical can cause cancer.

PI_NAMEs: ZHITKOVICH, ANATOLY  (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Alloys;Anabolism;Atmosphere;Binding;Biochemical Process;Biological Assay;Biological Markers;Cancer Etiology;Cancer Model;cancer risk;Cancerous;carcinogenicity;Carcinogenicity Tests;Carcinogens;Cell Cycle;cell transformation;Cells;Chemicals;Chemoprevention;Chemopreventive Agent;chromium hexavalent ion;Chromosome abnormality;Chromosome Fragile Sites;Dangerousness;Dependence;Development;DNA;DNA Adducts;DNA Damage;DNA replication fork;DNA Sequence Alteration;Dose;Early Diagnosis;Environment;Environmental Pollutants;Enzymes;epidemiologic data;Event;experimental study;Exposure to;Fiber;Fossil Fuels;Genetic;Genome;Genomics;Genotoxic Stress;genotoxicity;Goals;Human;Impairment;improved;Incineration;Individual;Industrialization;Inhalation Exposure;Knowledge;Lung;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Melanoma;Metabolic dysfunction;Metabolism;Metal Carcinogenesis;Metals;Methodology;Modeling;Molecular Abnormality;Municipalities;Mutagens;Mutation;Nickel;novel;Occupational Exposure;Oncogenes;Oncogenic;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Play;Population;potential biomarker;Predisposition;Prevention strategy;Process;Production;Public Health;Repression;Research;Ribonucleotide Reductase;Risk;Risk Assessment;Rodent;Role;RRM1 gene;RRM2 gene;S phase;Signal Transduction;Single-Stranded DNA;Site;Source;Specificity;Stainless Steel;Structure;Superfund;Testing;Thymidylate Synthase;Tumor Suppressor Genes;tumorigenic;wasting;Work

PROJECT_TITLE: Indirect Genotoxicity in Metal Carcinogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-T(06)]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: UNIVERSITY PARK

ORG_STATE: IA

PHR: Project Narrative With funds and support from this grant, Mid-Continental Association of Food and Drug Officials (MCAFDO) members will continue to gain and share information at our annual conference. Topics discussed at this event can be used in a number of health and food safety programs throughout the Midwest, increasing the success of consumer safety programs and initiatives throughout Arkansas, Iowa, Kansas, Missouri, Nebraska, Oklahoma, and Texas.

PI_NAMEs: PLATT, SCOTT J (contact)

PROGRAM_OFFICER_NAME: WEBB, SUZANNE

PROJECT_TITLE: MCAFDO Annual Education Conference