ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurosciences;Pain Research

ORG_CITY: ANN ARBOR

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE: Precise controlling and stimulation of neuronal-mediated saliva production is of eminent importance to an array of patients suffering from hyposalivation. In this project, the influence of somatosensory neurons on salivary flow and composition is determined with the prospect of paving the way for additional treatments that increase saliva production.

PI_NAMEs: LOMBAERT, ISABELLE M.A. (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: adeno-associated viral vector;Afferent Neurons;Anatomy;Animal Model;Anti-Hypertensive Agents;Anxiety;appetite loss;Atrophic;Attention;Autoimmune Diseases;autoimmune pathogenesis;Autonomic nervous system;Bioinformatics;Brain;calcium indicator;Cancer Etiology;cancer therapy;Cannulations;cell type;Cells;Chemotherapy and/or radiation;Classification;Comparative Anatomy;craniofacial tissue;Deglutition;Dental caries;Duct (organ) structure;Esthesia;Etiology;Evaluation;Excision;experience;Family suidae;Feedback;Fiber;Fluorescence-Activated Cell Sorting;Functional disorder;Functional Imaging;Gene Modified;Gland;Glandular Cell;global health;Goals;Health;Human;Immunofluorescence Immunologic;Impairment;In Situ;in vivo;Individual;Infusion procedures;insight;Insufflation;intercellular communication;irritation;Label;Ligation;Liquid substance;Mammals;Maps;Mastication;Mediating;Miniature Swine;Molecular;Monitor;Morbidity - disease rate;Mucous Membrane;Mus;nerve supply;Nervous System;Nervous System control;neuron component;Neurons;novel;novel therapeutic intervention;Obstruction;Operative Surgical Procedures;optogenetics;Oral;Oral health;oral pain;Organ;orofacial;Output;Pain;Parasympathetic Nervous System;Parotid Gland;Pathway interactions;Patients;Pattern;Peripheral;Pharmaceutical Preparations;Population;Production;Proteins;regenerative therapy;Reporter;Reporting;Research;response;Rodent;Role;Saliva;saliva mediated;saliva secretion;Salivary;Salivary Glands;Sensory;Sialolithiasis;single-cell RNA sequencing;Sjogren's Syndrome;Smell Perception;somatosensory;spatiotemporal;Stensen's duct;Stimulus;stressor;Structure;Structure of mucous membrane of nose;Sympathetic Nervous System;Taste Perception;Thick;Tissues;Tongue;tool;transcriptomics;Trigeminal System;Viral;Viscosity;Visualization;Work;Xerostomia

PROJECT_TITLE: Defining the Targets and Function of Direct Trigeminal Sensory Innervation to Salivary Glands

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: MD

ARRA_FUNDED: N

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: COLLEGE STATION

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative The proposed project will: 1) develop a novel human heat stress model based on physiological conditions of older adults and heat-related health risk assessments accounting for human heat stress and socio- environmental disparities experienced by older adults living in public housing, 2) elucidate the ambient cooling and biometeorological heat stress reduction effects of neighborhood green infrastructure characteristics, and 3) determine the sociopsychological mechanisms through which green infrastructure may buffer the adverse effects of heat exposure on health and well-being. The outcomes of this project will involve an age-specific heat stress model that can be used to assess population-level vulnerabilities and identified 3-dimensional green infrastructure attributes associated with reduced ambient heat and health risks via sociopsychological pathways. These outcomes will advance fundamental knowledge about the human-environment interaction related to heat exposure and heat-related health risks, as well as mitigation, in older adults, which is relevant to the NIH’s mission in enhancing health and preventing illness.

PI_NAMEs: LI, DONGYING  (contact)

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: 3-Dimensional;Accounting;Adopted;Adverse effects;Affective;age related;Aging;aging in place;Air;behavioral outcome;Buffers;Characteristics;Chicago;Cities;Classification;Climate;climate adaptation;climate disaster;Cognitive;college;Communities;Community Health;community planning;Complex;cost;Data;density;design;Development;Disadvantaged;Disparity;Dose;Emergency response;Emotional;Environment;Environmental Risk Factor;Equity;Event;experience;Exposure to;extreme heat;extreme weather;Face;Foundations;Frequencies;Future;Goals;Green space;Health;Heat Stress;Heat Stress Disorders;Housing;Human;Imagery;Impairment;Individual;Inequality;Infrastructure;innovation;insight;Investigation;Knowledge;Measures;Mission;Modeling;modifiable risk;neglect;Neighborhoods;novel;older adult;Older Population;Outcome;Pathway interactions;Personal Satisfaction;Physiologic Thermoregulation;Physiological;Physiology;Policies;Population;prevent;Proxy;psychologic;Public Health;public health intervention;Public Housing;Quasi-experiment;Rationalization;remote sensing;Research;resilience;response;Risk;Risk Assessment;Risk Factors;risk mitigation;Role;Sampling;Site;social;social disparities;Social Environment;Social outcome;social vulnerability;socioeconomics;stress reduction;stressor;Subgroup;Surveys;Temperature;Texas;Typology;United States National Institutes of Health;Vulnerable Populations

PROJECT_TITLE: Heat-Related Health Risk Assessment and Mitigation for Aging Populations in Public Housing: A Community-Individual Environment-Health Nexus

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PUBLIC HEALTH NARRATIVE The proposed research aims to develop and evaluate hepatocellular carcinoma (HCC) screening algorithms that incorporate changes in biomarkers over time to improve the likelihood of early detection and hence is highly relevant to the mission of the NCI. We hypothesize that our proposed HCC screening algorithms, which will utilize state-of-the-art statistical methods to integrate all the available information, will result in reduced harms (fewer false positives) and increased likelihood of early detection of HCC at a potentially curative stage. In our proposal we will utilize data from a range of study designs, with patients located throughout the US and being surveilled in multiple settings including academic hospitals, community hospitals and Department of Veteran's Affairs hospitals, ensuring robust development, evaluation and validation of our proposed algorithms. 1

PI_NAMEs: TAYOB, NABIHAH  (contact)

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: advanced disease;Algorithms;Behavior;Biological Markers;blood-based biomarker;California;Cancer Etiology;Cessation of life;Characteristics;Cirrhosis;Clinical;Clinical Data;clinical practice;cohort;Cohort Studies;Communities;Community Hospitals;Complement;Computerized Medical Record;cost effective;curative treatments;Data;Death Rate;Detection;Development;Diagnosis;Disease;Early Detection Research Network;Early Diagnosis;Ensure;Evaluation;flexibility;follow-up;Future;Goals;Guidelines;Harm Reduction;Hepatitis C Antiviral;Hospitals;improved;Incidence;innovation;Joints;Laboratories;Laboratory Markers;Lesion;Liver;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Methodology;Mission;Modeling;novel;novel marker;obese patients;Patient observation;Patients;Performance;phase 3 study;phase 4 study;pre-clinical;Preparation;Primary carcinoma of the liver cells;Prognosis;prospective;Public Health;Recommendation;Recording of previous events;Reporting;Research;Research Design;Retrospective cohort;Risk;screening;Screening for cancer;Serum;Statistical Methods;Symptoms;System;Testing;Texas;Time;tool;ultrasound;United States;United States Department of Veterans Affairs;United States National Institutes of Health;Update;Validation;α-Fetoproteins

PROJECT_TITLE: Biomarker screening algorithms for the improved early detection of hepatocellular carcinoma

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: VANCOUVER

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF BRITISH COLUMBIA

ORG_STATE: BC

ORG_ZIPCODE: V6T 1Z3

PHR: PROJECT NARRATIVE This study will employ an ethno-epidemiological approach to examine how drug supply changes and rising fentanyl-stimulant polysubstance use impact overdose vulnerability and the effectiveness of a comprehensive response to the overdose epidemic in Vancouver, Canada, including robust harm reduction and addiction treatment interventions. This study operates in connection with three NIDA-funded cohort studies and a NIDA- funded drug-checking evaluation project, and involves the integration of ethnographic and qualitative data with clinical, behavioral, and drug surveillance data. This study addresses critical research gaps by examining emerging dynamics fueling the overdose epidemic, and will generate evidence critical to optimize public health responses.

PI_NAMEs: KERR, THOMAS  (contact);MCNEIL, RYAN

PROGRAM_OFFICER_NAME: HAEGERICH, TAMARA

PROJECT_TERMS: addiction;Address;Behavioral;Benzodiazepines;Canada;Characteristics;Clinical;cohort;Cohort Studies;Collaborations;community partnership;Complex;Consumption;contingency management;COVID-19 pandemic;Data;Drug Adulterations;Drug Metabolic Detoxication;Drug usage;Drug user;Effectiveness;effectiveness/implementation study;Environment;Epidemic;Epidemiology;epidemiology study;Ethnography;Evaluation;evidence base;experience;Fentanyl;fentanyl test;fentanyl use;Fostering;Funding;Harm Reduction;health disparity;health disparity populations;Health system;Heroin;Housing;improved;Individual;Inequity;Inhalation;Injectable;innovation;insight;Interdisciplinary Study;interest;International;Intervention;Interview;Longitudinal cohort study;multiple data sources;naloxone dispensing;Naloxone Training;National Institute of Drug Abuse;North America;novel;Opioid;opioid agonist therapy;Oral;Outcome;Overdose;overdose death;overdose prevention;Pattern;Pharmaceutical Preparations;point of care;polysubstance use;Population;Poverty;prescription opioid;Prevalence;preventive intervention;Program Evaluation;programs;Public Health;Qualitative Methods;recruit;Research;Research Infrastructure;response;Risk;Sampling;scale up;Services;Shapes;Site;social;Social Sciences;social structure;Stimulant;substance use;surveillance data;test strip;Treatment outcome;treatment program;treatment response;United States National Institutes of Health

PROJECT_TITLE: An ethno-epidemiological study of the implementation and effectiveness of an innovative and comprehensive response to the evolving overdoseepidemic


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetic Testing;Genetics;Infectious Diseases;Orphan Drug;Precision Medicine;Prevention;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: CHAPEL HILL

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: The incidence of HPV-associated oropharyngeal squamous cell carcinoma (HPV+ OPSCC) has rapidly increased over the last two decades surpassing uterine cervical cancer as the most frequently diagnosed HPV-associated cancer in the United States by 2012. Treatment paradigms for HPV+ OPSCC have not kept up with this new disease entity, and there are currently no prognostic biomarkers to personalize therapeutic intensity and no tests for early detection of new or recurrent disease that are used clinically. Our team has discovered and piloted new assays for prognostication and early detection, and their validation through the proposed prospective observational trial would improve clinical care for these patients.

PI_NAMEs: ISSAEVA, NATALIA ;YARBROUGH, WENDELL G (contact)

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: Adoption;Aftercare;aged;aggressive therapy;Biological Assay;Biological Markers;Cancer Center;Cancer Control;Cancer Detection;cancer recurrence;Case/Control Studies;cervical and uterine cancer;Characteristics;chemotherapy;Cisplatin;Clinic;Clinical;clinical care;clinical diagnosis;Clinical Treatment;Clinical Trials;cohort;Community Clinical Oncology Program;Defect;Detection;detection assay;Diagnosis;digital;Disease;DNA;Early Diagnosis;Early Intervention;Enrollment;Epidemic;epidemiological model;Face;follow-up;Gene Mutation;General Population;Genes;Genome;genomic biomarker;Head and neck structure;High Prevalence;high risk;HPV negative;HPV screening;human papilloma virus oropharyngeal squamous cell carcinoma;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;improved;Incidence;Individual;Institution;Knowledge;Lead;life span;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measures;men;Methods;Monitor;Morbidity - disease rate;Mutation;Newly Diagnosed;Nodal;Non-Malignant;novel;novel marker;novel therapeutics;Observational Study;Oncogenic;Operative Surgical Procedures;oral HPV;oral HPV infection;oral infection;Oropharyngeal Squamous Cell Carcinoma;Outcome;outcome prediction;Patients;personalized care;personalized medicine;personalized screening;personalized therapeutic;Physicians;Plasma;predicting response;predictive tools;Predictive Value;prevent;prognostic;Prognostic Marker;prognostication;Progression-Free Survivals;prospective;Radiation;Radiation Dose Unit;Recurrence;Recurrent disease;Research Design;Risk;Risk Factors;Salvage Therapy;Sampling;screening;Screening for cancer;Screening procedure;Sensitivity and Specificity;sexually active;side effect;Smoking History;Specific qualifier value;Specificity;surveillance strategy;Testing;The Cancer Genome Atlas;Therapeutic;Time;TNF receptor-associated factor 3;treatment response;tumor;Tumor Tissue;United States;University of Texas M D Anderson Cancer Center;Validation;validation studies

PROJECT_TITLE: Observational study to validate circulating HPVDNA and prognostic genomic biomarkers for diagnosis and treatment of HPV-associated OPSCC


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Human Genome;Mental Health;Neurosciences

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Chronic unpredictable stress is an environmental risk factor for developing multiple diseases and influences the plasticity of reward substrates including the nucleus accumbens (NAc). The objective of this project is to study a population of NAc astrocytes expressing the b1 integrin, CD29, a pivotal receptor in ECM organization and a candidate mechanism impacting NAc plasticity, neural activity, and behavior. I will utilize single-cell multi-omic tools, spatial transcriptomics, animal behavioral paradigms, and in vivo calcium imaging to examine how CD29+ astrocyte subsets influence cell-cell interactions, ECM spatial organization, and neural activity in the NAc in response to unpredictable stress, which could lead to the identification of novel mechanisms relevant for mental health.

PI_NAMEs: WHEELER, MICHAEL ALEX (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Acute;acute stress;Affect;Animals;Astrocytes;Automobile Driving;Bar Codes;Behavior;behavior influence;Behavioral Paradigm;behavioral response;Binding;Blood - brain barrier anatomy;Cell Communication;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Central Nervous System;Chronic;Chronic stress;Complex;Corpus striatum structure;Data;Deposition;Disease;Environment;Environmental Risk Factor;environmental stressor;Exhibits;Exposure to;Extracellular Matrix;Extracellular Matrix Proteins;Family;genome-wide;Goals;Heterogeneity;high throughput screening;Image;in vivo;in vivo calcium imaging;Inflammation;Integrin alpha Chains;Integrin beta Chains;Integrins;Interneurons;Ligands;Location;Maps;Measures;Membrane;Membrane Proteins;Mental Health;Methods;Molecular;multiple omics;Mus;neural;Neuroglia;Neurons;neuroregulation;novel;Nucleus Accumbens;Operant Conditioning;Parvalbumins;Peptides;Play;Population;Process;Proteoglycan;Publishing;receptor;Regulation;Research;response;Rewards;RNA;Role;Shapes;single-cell RNA sequencing;Specific qualifier value;Stress;stressor;Structure;Surface;Techniques;Testing;tool;Tracer;transcriptomics;Viral

PROJECT_TITLE: Control of extracellular matrix remodeling by CD29+ astrocytes

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: One of the biggest weaknesses in our understanding of the nervous system is at the level of local microcircuits; clusters of functionally related synapses that shape the responses of individual dendrites. We propose to study the development and function of the local microcircuitry (synaptic glomeruli) of the mouse visual thalamus. By combining cutting-edge three-dimensional electron microscopy with functional characterization and activity manipulation we will test whether developmental retinal activity shapes the local synaptic organization of the visual thalamus into subcellular feature detectors.

PI_NAMEs: MORGAN, JOSHUA L (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: 3-Dimensional;Address;Architecture;Axon;Biological Models;Calcium;cell type;Cells;Color;Complex;Dendrites;detector;Development;Dorsal;Electron Microscopy;Encapsulated;Excitatory Synapse;experience;experimental study;Eye;feature detection;feature selection;Fire - disasters;functional group;Gene Silencing;glomerular function;Grouping;Image;individual response;inhibitory neuron;Inhibitory Synapse;insight;Label;Lateral Geniculate Body;Learning;Light;light deprivation;Link;Maps;mouse development;Mus;Nerve Tissue;Nervous System;Neurites;Neuroglia;neuronal cell body;Neurons;Neuropil;optical imaging;optogenetics;Output;Pathology;Pattern;Phase;postnatal;postnatal development;Process;Property;receptive field;reconstruction;response;Retina;retinal axon;Retinal Ganglion Cells;Role;segregation;Series;Shapes;Signal Transduction;Specificity;Structure;Synapses;synaptic function;synaptogenesis;Testing;Thalamic structure;timeline;Transgenic Organisms;transmission process;Vision;vision development;Visual;Visual Cortex;visual deprivation;visual information;visual processing

PROJECT_TITLE: Development and function of glomerular microcircuits in the visual thalamus

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: SURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Rapid transport to a designated/verified trauma center (TC) is associated with a 25% reduction in mortality among injured trauma patients; however, timely and equitable access to Emergency Medical Services (EMS) and to emergency health care services such as trauma care is understudied. We aim to identify socio-spatial disparities using the area deprivation index and dissimilarity index in the expeditious availability to EMS and access to TCs among critically injured trauma patients, factors driving those disparities, and the association of those disparities with patient outcomes. This project will enhance the knowledge necessary to design interventions at the system level to improve outcomes by reducing and eliminating disparities in trauma morbidity and mortality.

PI_NAMEs: BERRY, CHERISSE D. (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adult;African American population;aged;American;Area;Automobile Driving;Black race;care systems;Caring;Cause of Death;Cessation of life;Child;cohort;Data;Data Science;Database Management Systems;Databases;deprivation;design;Disparity;disparity elimination;disparity reduction;District of Columbia;Emergency Care;Emergency medical service;Emergency Situation;Enrollment;Equity;ethnic minority population;Ethnic Origin;experience;Geography;Goals;Health;health care service;health disparity;health equity;health inequalities;Health Services Accessibility;high risk;Hospitals;improved;improved outcome;indexing;Information Sciences;Information Systems;injured;Inpatients;Insurance Coverage;Intervention;intervention effect;Knowledge;Life;Measurable;Measurement;Methods;Minority Groups;Modeling;Morbidity - disease rate;mortality;mortality risk;Neighborhoods;novel;Outcome;Patient-Focused Outcomes;Patients;Persons;Phase;Policies;Policy Developments;Population;Poverty;predictive modeling;prevent;programs;Public Health;public health insurance;Race;racial minority population;Reaction Time;Research;Role;segregation;severe injury;social health determinants;Socioeconomic Factors;Socioeconomic Status;spatial epidemiology;spatiotemporal;Stroke;System;Testing;therapy design;Time;time use;Transportation;Trauma;trauma care;trauma centers;Trauma patient;Traumatic injury;United States

PROJECT_TITLE: Health Equity in Emergency Trauma Care: Analysis of disparities in the pre-hospital emergency trauma care system

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Genetics;Nanotechnology;Orphan Drug;Ovarian Cancer;Precision Medicine;Rare Diseases;Vaginal Cancer;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Relevance to Public Health The efficiency of chemotherapy for gynecological cancers varies substantially from patient to patient because mechanisms of tumor development, drug resistance and rate of proliferation can be significantly different in each patient. We propose to select anticancer drug(s) and suppressors of cellular proliferation, drug resistance and metastases (i.e. nucleic acids) based on an individual genetic profile, determined in tumor tissues obtained from patients with gynecological cancers. It is expected that the proposed individualized treatment for gynecological malignancies will substantially enhance therapeutic efficacy of chemotherapy and will be effective for every particular patient.

PI_NAMEs: MINKO, TAMARA  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Address;anticancer activity;Antineoplastic Agents;Biological Markers;cancer cell;Cancer Model;cancer type;Cell Culture Techniques;Cell Death Induction;Cell Proliferation;Cell Separation;Cervical;chemotherapy;Clinical;Clinical Trials;clinically relevant;Complex Mixtures;Cytotoxic agent;Data;design;Development;Diagnosis;dosage;Dosage Forms;Drug Delivery Systems;drug metabolism;Drug resistance;drug sensitivity;Effectiveness;Endometrial;Future;Genes;Genetic;genetic information;genetic makeup;genetic profiling;Genotype;Goals;Human Genetics;human model;in vitro testing;in vivo;Individual;individual patient;individualized medicine;Investigation;Lipids;lipophilicity;Liposomes;malignant ascites;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of vulva;Malignant Neoplasms;Malignant Vaginal Neoplasm;Mammalian Oviducts;Messenger RNA;Modeling;Molecular Profiling;Molecular Target;Mus;nanocarrier;Nanostructures;Nanotechnology;National Cancer Institute;Neoplasm Metastasis;novel strategies;novel therapeutics;Nucleic Acids;Operative Surgical Procedures;Organ;Outcome;Ovarian Carcinoma;overexpression;Patients;Peptides;personalized approach;personalized chemotherapy;personalized medicine;Pharmaceutical Preparations;Phenotype;prevent;Primary Neoplasm;profiles in patients;Proliferating;protein expression;Proteins;Public Health;Radiation therapy;Recommendation;Research;Resistance;response;Sampling;side effect;Small Interfering RNA;Standardization;structured lipid;subcutaneous;System;targeted delivery;Testing;Tissue Sample;Tissues;Translational Research;Translations;Treatment Effectiveness;Treatment Efficacy;treatment planning;Treatment Protocols;tumor;Tumor Debulking;tumor growth;Tumor Tissue;United States;Uterus;Variant;Woman;Xenograft Model

PROJECT_TITLE: Nanotechnology-based personalized treatment of metastatic ovarian cancer

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: Obesity causes expansion of adipose tissue and is a major contributor to cardiovascular disease. This project studies human adipose tissue directly surrounding blood vessels. We focus on patient populations in generally good health versus those with different vascular diseases. Our studies will broaden understanding of how adipose drives disease or can be protective to vascular health.

PI_NAMEs: LIAW, LUCY  (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: 3-Dimensional;Abdomen;Abdominal Aortic Aneurysm;Activities of Daily Living;Address;adipocyte differentiation;Adipocytes;Adipose tissue;Adult;Affect;Aneurysm;Aorta;Area;Atherosclerosis;Automobile Driving;Biology;Blood Vessels;Brown Fat;Calories;Cardiometabolic Disease;Cardiovascular Diseases;cardiovascular health;Cardiovascular Pathology;cardiovascular risk factor;Cell Lineage;Cell Physiology;Cells;Clinical;Collaborations;Collection;Coronary artery;Diet;Disease;Disease Progression;Fibroblasts;Genetic;Goals;Health;Heart;Human;human RNA sequencing;human stem cells;In Vitro;insight;interest;Laboratories;lipidomics;Lipids;Measures;Mediating;Metabolic;Metabolic Diseases;Mitochondria;Modeling;Molecular;molecular phenotype;Molecular Profiling;mouse model;Mus;Nature;Newborn Infant;NOTCH3 gene;novel;Obesity;Operative Surgical Procedures;Paracrine Communication;Pathology;Pathway interactions;patient population;Patients;Phenotype;Physiological;Population;Prevalence;Process;progenitor;Proteomics;Protocols documentation;Regulation;Research;response;Role;Severities;Signal Transduction;single nucleus RNA-sequencing;Smooth Muscle Myocytes;Specificity;stem cell population;stem cells;Stimulus;subcutaneous;Sympathetic Nervous System;Temperature;Testing;Therapeutic;Thermogenesis;Thoracic aorta;Time;Tissue Donors;Tissue Sample;transcriptomics;translational approach;Translational Research;translational study;Vascular Diseases;Vascular Smooth Muscle;Work

PROJECT_TITLE: Regulation of arterial phenotype by perivascular adipose tissue in cardiometabolic disease

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE – OVERALL The Stanford Cancer Institute (SCI) brings together researchers from across Stanford University with the goals of improving cancer prevention, detection, diagnosis, treatment, and outcomes for individuals and for populations, both within our region and in the world at large. The SCI has a compelling history of cancer discovery that has accelerated with the development of innovative new technologies, a strong focus on understanding the etiologies of cancers in individuals and in populations, a proven track record in implementing high impact clinical trials and a mission to translate findings to improve the care of cancer patients. With the support of the Cancer Center Support Grant, the SCI makes major contributions across the spectrum of research from basic discovery through clinical application to the population sciences that will enhance our understanding of disease processes, bring new diagnostic and therapeutic modalities to patients, facilitate risk assessment and prevention, and improve the overall outlook for individuals afflicted with or at risk for cancer.

PI_NAMEs: ARTANDI, STEVEN E (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Acceleration;Address;Animals;anti-cancer research;Antineoplastic Agents;Area;base;Basic Cancer Research;Basic Science;Biological Sciences;Biomedical Engineering;biomedical informatics;Biometry;California;Cancer Biology;cancer care;Cancer Center Support Grant;Cancer Detection;Cancer Etiology;Cancer health equity;cancer imaging;cancer immunotherapy;Cancer Patient;cancer prevention;cancer risk;cancer stem cell;cancer therapy;CAR T cell therapy;Catchment Area;Cells;Clinical;clinical application;clinical care;Clinical Data;Clinical Oncology;Clinical Protocols;Clinical Research;Clinical Trials;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;County;data management;Detection;Development;Diagnosis;Disease;Doctor of Philosophy;drug discovery;Early Diagnosis;effective therapy;Engineering;Epidemiology;experience;Faculty;Flow Cytometry;Fostering;Funding;Genetic;Genomics;Goals;health equity;Hematologic Neoplasms;Human;Humanities;Image;imaging detection;Immunologic Monitoring;Immunology;improved;Incidence;Individual;innovation;Investments;Leadership;Malignant Neoplasms;Medicine;member;Mission;Modality;Modeling;Monitor;new technology;next generation;novel diagnostics;novel strategies;novel therapeutics;Outcome;Patient Care;Patient-Centered Care;Patients;Peer Review;Physicians;Population;population based;population health;Population Heterogeneity;Population Sciences;Prevention;Prevention approach;Process;programs;Proteomics;Protocols documentation;Radiobiology;Recording of previous events;recruit;Research;Research Personnel;Resource Sharing;Risk Assessment;Schools;Science;Scientist;screening;Talents;technology development;Therapeutic;Tissue Procurements;Training;Training and Education;Translating;Translations;tumor;United States National Institutes of Health;Universities

PROJECT_TITLE: Stanford Cancer Institute

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Breast Cancer;Cancer;Radiation Oncology;Women's Health Research

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE This proposal will investigate a novel mechanism that contributes to radioresistance. Specifically, I will focus on the role of Vascular Endothelia Growith Factor (VEGF) binding to Neuropilin-2 (NRP2) in limiting oxidative stress during radiation treatment. Furthermore, I will collect preclinical data regarding the use of a function blocking antibody against VEGF/NRP2 (aNRP2-10) during radiation treatment to examine its efficacy as a novel therapeutic approach for TNBC patients.

PI_NAMEs: KUMAR, AYUSH  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Adjuvant Chemotherapy;Antioxidants;bench to bedside;Binding;Blocking Antibodies;Breast Cancer Cell;Breast Cancer Patient;Breast-Conserving Surgery;cancer stem cell;cancer subtypes;carcinogenesis;Cell Death;Cell Survival;Cells;clinically significant;Data;DNA Damage;Effectiveness;effectiveness evaluation;Extinction;Failure;Fellowship;Gene Expression Profile;Genes;Genetic Transcription;Goals;Growth;Homeostasis;improved;In complete remission;in vivo Model;insight;irradiation;knock-down;Literature;Malignant Breast Neoplasm;Mediating;Metabolic;Metabolic Pathway;Molecular;molecular subtypes;Nature;Neoadjuvant Therapy;neoplastic cell;Neuropilin-2;Nitric Oxide;Nitric Oxide Synthase;novel;novel therapeutic intervention;Nuclear;Organoids;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;Pathologic;Pathway interactions;patient derived xenograft model;Patients;Phenotype;Physicians;Population;pre-clinical;Prognosis;Property;Radiation;radiation resistance;Radiation therapy;Radiation Tolerance;radioresistant;Reactive Inhibition;Reactive Oxygen Species;receptor;Recurrence;Regulation;relapse patients;relapse prevention;Research;Residual Neoplasm;Resistance;resistance mechanism;response;Role;Scientist;self-renewal;Signal Induction;Signal Transduction;single-cell RNA sequencing;stem cells;Surgical Management;Survival Rate;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;therapy outcome;therapy resistant;traditional therapy;Training;treatment response;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor heterogeneity;Variant;Vascular Endothelial Growth Factors;Vascular Endothelium

PROJECT_TITLE: VEGF/Neuropilin-2 Signaling and Radioresistance in Triple-Negative Breast Cancer


NIH_SPENDING_CATS: Cancer

PI_NAMEs: ADAMS, LAURA  (contact)

PROJECT_TERMS: Achievement;acronyms;Adherence;Advocacy;Animals;anti-cancer research;Applications Grants;Appointment;Award;Basic Science;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Detection;Cancer health equity;cancer immunotherapy;Cancer Research Infrastructure;cancer stem cell;Catchment Area;Cell Therapy;Child Health;Clinical;Clinical Data;Clinical Protocols;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communication;community advisory board;community engagement;Community Outreach;community partners;community partnership;COVID-19 pandemic;Data;data management;diversity and inclusion;Doctor of Philosophy;Early Diagnosis;Education;Evaluation;Event;experience;Faculty;Faculty Recruitment;Fostering;Foundations;Funding;Future;Goals;Grant;Healthcare;Healthcare Systems;Hematologic Neoplasms;Human Resources;imaging detection;improved;Infrastructure;Infusion procedures;innovation;Institution;Intervention;Lead;Leadership;Malignant Neoplasms;medical schools;meetings;member;Mission;Modeling;Nodal;Office of Administrative Management;operation;Organizational Culture;Outcome;Parents;Patients;Performance;Persons;Pilot Projects;Population Sciences;Positioning Attribute;Process;Productivity;Program Development;Program Evaluation;programs;Radiobiology;recruit;Reporting;Research;Research Institute;Research Personnel;Resource Sharing;Resources;Schools;Science;Services;Shelter facility;Strategic Planning;Structure;success;Therapeutic;Time;Tissue Procurements;Training and Education;Translational Research;treatment trial;tumor;Universities;Update;virtual;Writing

PROJECT_TITLE: Cancer Center Administration


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CLEMSON

ORG_DEPT: BIOLOGY

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: PROJECT NARRATIVE Eukaryotic pathogens cause devastating diseases in humans including malaria, dysentery, sleeping sickness, and meningitis. A world-class center, the Eukaryotic Pathogens Innovation Center (EPIC), will be supported at Clemson University. Research in this center will provide insight into the biology and virulence of this class of pathogens and will enhance the scientific visibility of the state of South Carolina.

PI_NAMEs: MORRIS, JAMES CULVIN (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Advisory Committees;African Trypanosomiasis;Amebic colitis;anti-fungal agents;Antiparasitic Agents;Area;Aspergillosis;Aspergillus fumigatus;Assistantship;Award;Azoles;base;Bioinformatics;Biology;Bioterrorism;Cardiovascular Diseases;Cell Separation;Centers of Research Excellence;Chagas Disease;Classification;climate change;Collaborations;college;Colon Carcinoma;Communicable Diseases;Communication;Complex;Country;Cryptococcus;Detection;Development;Diagnosis;dietary supplements;Disease;drug discovery;Dynein ATPase;Dysentery;Educational workshop;emerging pathogen;Environment;Environmental Risk Factor;Equipment;Evolution;Faculty;Faculty Recruitment;Fostering;Funding;Fungal Meningitis;Genomics;Global Change;Goals;graduate student;Grant;Helminths;Host Defense;Human;human disease;Image;imaging facilities;Incidence;Infection;Infrastructure;innovation;insight;Institution;Interdisciplinary Study;Knowledge;Leadership;Light;lipidomics;Macrophage;Malaria;Medical;member;Meningitis;Mentors;Modeling;multidisciplinary;Musculoskeletal Diseases;neglect;neglected tropical diseases;Oxidants;Parasites;Parasitic Diseases;pathogen;Phase;Pilot Projects;Postdoctoral Fellow;Poverty;primary amebic meningoencephalitis;Probability;Program Research Project Grants;programs;recruit;Regulation;Research;Research Personnel;Resource Allocation;response;Role;Scientist;skills;South Carolina;Stress;Stroke;Student recruitment;success;targeted treatment;tenure track;tissue regeneration;Toxoplasmosis;Training;transmission process;Trichomonas Infections;Trypanosoma;United States National Institutes of Health;Universities;Vaccines;vector;Virulence;Zebrafish

PROJECT_TITLE: COBRE: Eukaryotic Pathogens Innovation Center (EPIC)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases

PI_NAMEs: SMITH, KERRY SCOT (contact)

PROJECT_TERMS: Acceleration;Advisory Committees;Amoeba genus;Area;Aspergillus;Award;Biochemical;Bioinformatics;biophysical techniques;Cellular biology;Centers of Research Excellence;Chemicals;Collaborations;college;Core Facility;Cryptococcus;Development;Discipline;Disease;Eligibility Determination;Ensure;Entamoeba;Equipment;Faculty;Fellowship;Funding;Funding Agency;fungus;Genetic;Genomic approach;Genomics;graduate student;Grant;Growth;Health;Human Resources;imaging facilities;improved;Individual;Infrastructure;innovation;interest;International;Leadership;Light;Mastigophora;meetings;member;Mentors;Molecular;Monitor;Naegleria;obligate intracellular parasite;Parasites;pathogen;Pathogenesis;Phase;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Probability;Productivity;programs;Publishing;Records;recruit;Research;Research Infrastructure;Research Personnel;Science;Scientist;South Carolina;Southeastern United States;Structure;success;tenure track;tool;Toxoplasma;Training;Trichomonas;Trustees;Trypanosoma;United States National Institutes of Health;Universities;University adminstration;Work

PROJECT_TITLE: Administrative Core - EPIC


NIH_SPENDING_CATS: Aging;Atherosclerosis;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE (Public Health Relevance Statement) Age-related macular degeneration (AMD) is the leading cause of irreversible blindness among elderly Americans, which has a devastating socioeconomic burden, particularly since there is currently no cure. Our proposed studies are designed to (1) mechanistically determine the interaction of two risk factors, complement factor H (CFH) and lipoproteins in AMD, and (2) establish if augmenting CFH and/or targeting high density lipoproteins are viable approaches for treating AMD. The proposed research is relevant to the National Eye Institute high priority research area, Intersection of Aging & Biological Mechanisms of Eye Disease, as well as to the National Institute on Aging research goal to Improve Understanding of Healthy Aging and Disease.

PI_NAMEs: BOWES RICKMAN, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Address;Affect;Age;age related;Age related macular degeneration;aged;Aging;Alternative Complement Pathway;American;Amino Acids;Animal Model;Apolipoprotein A-I;apolipoprotein B-48;Apolipoprotein E;Apolipoproteins;Apolipoproteins B;Area;Binding;Biochemical;Biological;Blindness;Blood;Bruch's basal membrane structure;Cells;Cessation of life;Cholesterol;Choroid;Complement;Complement Activation;Complement Factor H;complement system;Complex;Data;Deposition;design;Developed Countries;Development;Diet;Disease;Drusen;Economic Burden;Elderly;Epidemiology;epidemiology study;Epithelial Cells;extracellular;Eye;Eye diseases;Fatty acid glycerol esters;Functional disorder;Generations;Genes;genetic analysis;Genetic Complementation Test;Genetic Polymorphism;Genetic Risk;genome wide association study;Glycosaminoglycans;Goals;healthy aging;High Density Lipoproteins;Histidine;Human;human induced pluripotent stem cells;improved;in vivo;in vivo Model;Length;Link;lipid metabolism;Lipids;Lipoproteins;Liver;Metabolism;mimetics;Modeling;mouse model;Mus;National Eye Institute;National Institute on Aging;novel;old mice;Outcome Study;particle;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Peptides;Phenotype;Pigment Epithelium;Plasma;Positioning Attribute;prevent;Proteins;Proteome;public health relevance;Research;Research Priority;reverse cholesterol transport;Risk;Risk Factors;risk variant;RNA Splicing;socioeconomics;Testing;therapeutic target;trafficking;Transgenic Mice;Tyrosine;Variant

PROJECT_TITLE: Complement factor H modulates lipoprotein clearance in AMD

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


PI_NAMEs: FORD, JAMES M. (contact)

PROJECT_TERMS: American Cancer Society;anti-cancer research;Appointment;Area;Award;Cancer Biology;cancer care;cancer education;Cancer health equity;career;career development;Catchment Area;Clinical Research;community engagement;Community Outreach;Creativeness;design;Development;diversity and inclusion;Education;Educational Activities;Educational Needs Assessments;Engineering;Evaluation;Extramural Activities;Faculty;Faculty Recruitment;faculty research;Fellowship Program;Fostering;Funding;Funding Agency;Future;Genetic;graduate student;Grant;High School Student;Humanities;improved;Infrastructure;Institution;Leadership;Malignant Neoplasms;medical schools;Medicine;meetings;member;Mentors;Mentorship;Mission;novel strategies;Oncology;Outcome;Paper;Pediatrics;Peer Review;Positioning Attribute;Postdoctoral Fellow;Preparation;professor;programs;Recording of previous events;recruit;Research;Research Institute;Research Methodology;Research Training;Resources;Schedule;Science;Scientific Inquiry;Series;Strategic Planning;Students;symposium;System;Thinking;Training;Training Activity;Training and Education;training opportunity;Training Programs;Translational Research;undergraduate student;Underrepresented Minority;Underrepresented Students;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: Cancer Research Training and Education Coordination


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Infectious Diseases;Networking and Information Technology R&D (NITRD)

PI_NAMEs: PARKINSON, CHRISTOPHER L (contact)

PROJECT_TERMS: Applications Grants;Architecture;Award;Bioinformatics;bioinformatics infrastructure;bioinformatics tool;Biological Sciences;Biology;Centers of Research Excellence;college;Communities;complex data;Computational Biology;computer infrastructure;Computers;computing resources;Data;Data Analyses;Data Files;Data Science;design;Development;doctoral student;Education;Education and Outreach;Educational workshop;empowerment;Epigenetic Process;Equipment;equipment acquisition;Event;expectation;Faculty;faculty research;Funding;Generations;Genes;Genetic;genome resource;genome sciences;genome sequencing;Genomic medicine;genomic tools;Genomics;Goals;graduate student;Health;High Performance Computing;human capital;Human Genetics;Human Resources;improved;Information Sciences;Infrastructure;innovation;insight;Institution;Investments;Laboratories;Magnetic Resonance Imaging;Measures;member;Memory;Mission;Modeling;Molecular;next generation;next generation sequencing;Nucleic acid sequencing;pathogen;peer;Performance;Phase;Pilot Projects;Postdoctoral Fellow;precision medicine;Process;programs;Publications;Pythons;Research;Research Personnel;Resources;Reverse Transcriptase Polymerase Chain Reaction;Science;Secure;Services;South Carolina;Specialist;Strategic Planning;Structure;Students;Supercomputing;Supervision;System;Teacher Professional Development;Technology;therapeutic development;Therapeutic Intervention;therapy development;tool;Training;training opportunity;transcriptome sequencing;United States National Institutes of Health;Universities;Variant

PROJECT_TITLE: Clemson University Genomics and Bioinformatics Facility (CUGBF)


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE A significant subset of pancreatic cancer patients harbors gain-of-function mutations and amplification of GNAS(Gα-s), however the function of mutant GNAS has remained elusive. The goal of this proposal is to understand how mutant GNAS driven signaling couple the core transcriptional and metabolic circuitry to propel tumor growth. Here we will use advanced organoid models, genetically engineered animals, patient-derived xenografts combined with global transcriptomics, isotopomer-based metabolic labeling and advanced microscopy to decipher oncogenic network of mutant GNAS in pancreatic cancer.

PI_NAMEs: PATRA, KRUSHNA CHANDRA (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Animal Cancer Model;Animals;biliary tract;Biochemical Pathway;Bioenergetics;Biology;Branched-Chain Amino Acids;cancer cell;Cancer Etiology;Cell Line;Cells;Cessation of life;Citric Acid Cycle;clinically relevant;Colon;Complex;CREB1 gene;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Dependence;Detection;Disease;Doxycycline;Enzymes;fatty acid oxidation;Fatty Acids;Foundations;gain of function mutation;Gene Expression;Genes;Genetic;Genetic Engineering;Genetic Transcription;Genetically Engineered Mouse;Genotype;Gnas protein;Goals;Growth;GTP-Binding Protein alpha Subunits, Gs;GTP-Binding Proteins;Heterogeneity;Histologic;Human;improved;inhibitor;Intestines;KRAS oncogenesis;KRAS2 gene;Label;Lesion;Lipids;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;metabolic phenotype;Methods;Microscopy;Mitochondria;Modeling;Molecular;Molecular Profiling;mouse model;Mucinous;Mucinous Neoplasm;Multienzyme Complexes;Mus;mutant;Mutate;Mutation;NADH;Neoplasms;novel;Nuclear Translocation;Oncogenic;Organoids;Other Genetics;Oxidative Phosphorylation;Oxidoreductase;Pancreas;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;Papillary;Pathway interactions;patient derived xenograft model;Phosphorylation;Pituitary Gland;pre-clinical;prevent;programs;Proliferating;protein activation;Protein Isoforms;Publishing;Recurrence;Regulation;Research;Respiration;respiratory;restraint;Role;salt-inducible kinase;Sampling;Series;Signal Transduction;Source;Specimen;Stomach;System;tool;TP53 gene;Transcription Coactivator;Transcriptional Activation;transcriptomics;treatment response;treatment strategy;tumor;tumor growth;Tumor Suppressor Proteins;United States;Up-Regulation;Work

PROJECT_TITLE: Investigating the molecular mechanisms of growth in GNAS mutant pancreatic cancer.

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: ATTARDI, LAURA D (contact)

PROJECT_TERMS: Area;ATAC-seq;Basic Science;Biological;Biological Models;Cancer Biology;cancer cell;cancer diagnosis;cancer initiation;cancer stem cell;cancer therapy;carcinogenesis;Carcinoma;Cell Culture System;Cells;Chromatin;Clinical;Clinical Investigator;Clinical Trials;Collaborations;Development;Doctor of Philosophy;drug development;Eating;Engineering;Epithelium;Erinaceidae;Faculty Recruitment;Focus Groups;Funding;Future;Gene Expression;Genetic;Genetically Engineered Mouse;Genomics;Goals;Grant;Group Meetings;Growth;Humanities;improved;Infrastructure;inhibitor;insight;Institution;Journals;Lung;Macrophage;Malignant Breast Neoplasm;Malignant lymphoid neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuscripts;medical schools;member;Modeling;mouse model;Neoplasm Metastasis;neoplastic cell;new technology;new therapeutic target;Normal tissue morphology;novel;novel strategies;novel therapeutics;Organoids;Pancreas;Pathway interactions;Peer Review;peer support;Pharmaceutical Preparations;preclinical study;programs;Proteomics;Publishing;Regulation;Research;Research Peer Review;Resource Sharing;Role;Science;self-renewal;Signal Pathway;Signal Transduction;small molecule;Solid Neoplasm;Source;Structure;Therapeutic;therapeutic protein;therapeutic target;tissue stem cells;Translating;translational impact;Translational Research;treatment response;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Suppressor Proteins;tumorigenesis;United States National Institutes of Health;Woman;Work;working group

PROJECT_TITLE: Cancer Biology and Cancer Stem Cells


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Burden of Illness;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE This project is relevant to public health because it identifies the trajectories, risk factors, and outcomes of functional impairment that develops in middle age. This study will help inform prevention of functional impairment in middle age by providing data to support next-step development and testing of interventions to improve functional outcomes, and will inform policy planning to mitigate the projected burden of functional impairment and associated adverse outcomes.

PI_NAMEs: BROWN, REBECCA TYLER (contact)

PROGRAM_OFFICER_NAME: DUTTA, CHHANDA

PROJECT_TERMS: Activities of Daily Living;acute care;Address;Admission activity;Adult;adverse outcome;Age;age acceleration;age group;Age of Onset;aging population;American;built environment;Cardiovascular Diseases;Chronic;Data;design;Development;Diabetes Mellitus;disability;Disability Insurance;economic outcome;Education;Employment;Enrollment;Environmental Risk Factor;Epidemiology;experience;functional decline;Functional impairment;functional improvement;functional outcomes;functional status;Funding;Health;Health and Retirement Study;Health behavior;health care service utilization;high school;hospital care;Hospitalization;human old age (65+);Impairment;Incidence;Individual;Intercept;Intervention;late life;Life;Life Cycle Stages;Link;Long-Term Effects;Longitudinal Studies;low socioeconomic status;Measures;Mediating;Mental Depression;middle age;Modeling;modifiable risk;mortality;neighborhood safety;nursing home length of stay;Nursing Homes;Obesity;older adult;Outcome;Participant;Pattern;Persons;Physical environment;Physical Performance;Policies;poor health outcome;Population Attributable Risks;premature;Premature Mortality;Prevalence;Prevention;protective factors;Public Health;Reporting;Research;Risk;Risk Factors;Social Environment;Subgroup;Testing;theories;Time;trend;Visit;Work

PROJECT_TITLE: Functional Impairment in Middle-Aged Adults

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


PI_NAMEs: BRUCE, TERRI LANE FOSTER (contact)

PROJECT_TERMS: Address;base;Biochemical;Biological Sciences;Cell Count;Cell Physiology;Cell Separation;Cells;Centers of Research Excellence;Charge;collaborative environment;Communities;Conceptions;Core Facility;Cytometry;Data;Data Analyses;design;Development;Education;Educational workshop;Equipment;equipment training;experimental study;Faculty;Fees;Floor;Flow Cytometry;Fluorescence;Fluorescence-Activated Cell Sorting;Fostering;Funding;Generations;Grant;Human Resources;Image;imaging facilities;Imaging Techniques;improved;innovation;Institution;interest;Light;Light Cell;light microscopy;Location;member;Microscope;Microscopy;multi-photon;Organelles;pathogen;Phase;Positioning Attribute;Recording of previous events;Research;Research Personnel;Resources;skills;Sorting;South Carolina;Students;success;superresolution microscopy;Targeted Research;Technical Expertise;Techniques;Technology;tool;Training;ultra high resolution;United States National Institutes of Health;Universities;university student;Visualization;web page;Work

PROJECT_TITLE: Clemson Light Imaging Facility (CLIF)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Precision Medicine;Radiation Oncology

PI_NAMEs: LE, QUYNH-THU XUAN (contact)

PROJECT_TERMS: Acute;Animals;Area;Artificial Intelligence;Basic Science;Biological;Biological Assay;Biological Markers;Biological Products;Biology;biomarker validation;Blood;cancer cell;cancer genomics;Cancer Patient;cancer radiation therapy;cancer survival;Cell Physiology;chemotherapy;Clinical Trials;Collaborations;Data;deep learning;detection method;Detection of Minimal Residual Disease;Development;Devices;Doctor of Philosophy;Dose;Dose Rate;Effectiveness;Electrons;end of life;Engineering;Fostering;Functional Imaging;Funding;Genetic;Genomics;Goals;Grant;Humanities;Hypoxia;image-guided radiation;Immune;Immune system;Immunotherapy;improved;innovation;Institution;Knowledge;Laboratories;Linear Accelerator Radiotherapy Systems;liquid biopsy;Malignant neoplasm of lung;Malignant Neoplasms;Manuscripts;Medical Records;medical schools;member;Modeling;molecular imaging;Monitor;Natural Language Processing;Neoplasm Metastasis;neoplastic cell;New Agents;new technology;Normal tissue morphology;novel;novel marker;outcome prediction;Patients;Peer Review;peer support;personalized medicine;pharmacologic;Positron-Emission Tomography;Pre-Clinical Model;Prognosis;prognostic model;programs;Property;prospective;Protocols documentation;Publishing;quality of life for cancer survivors;Radiation;radiation delivery;Radiation Oncology;radiation resistance;Radiation therapy;Radiation Tolerance;Radiobiology;radiomics;radiotracer;recruit;Research;Research Peer Review;Research Personnel;Residual Neoplasm;Resource Sharing;Resources;response;Retirement;Safety;Scanning;Schools;Science;Screening for cancer;Source;stem cells;Stromal Cells;Symptoms;targeted treatment;technology development;Therapeutic Index;Toxic effect;Translating;Translational Research;treatment planning;treatment response;Treatment-related toxicity;tumor;Tumor Biology;tumor DNA;tumor metabolism;tumor microenvironment;Tumor Tissue;United States National Institutes of Health;uptake;Urine;Work

PROJECT_TITLE: Radiation Biology


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Even when successfully cured with antibiotics, tuberculosis patients often suffer from permanently impaired lung function, necessitating the advent of new therapeutic strategies to ensure better outcomes. The use of host directed therapies that limit non-productive inflammation represents a promising approach, but development has been complicated by the substantial degree of heterogeneity observed in individual immune responses to Mtb infections. The proposed research seeks to define the contribution of the unfolded protein response to immune response heterogeneity and inflammation during Mtb infection, and to assess the feasibility of targeting specific unfolded protein response pathways to improve TB outcomes.

PI_NAMEs: FINETHY, RYAN HAROLD (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Antibiotics;ATF6 gene;Bacteriology;Bar Codes;Bone Marrow;burden of illness;Cells;Cellular Stress;Chemicals;Chronic;cohort;Communication;cytokine;Data;defined contribution;Development;Disease;Disease Outcome;Disease Progression;DNA;Endoplasmic Reticulum;Ensure;Environment;Exhibits;experience;experimental study;falls;Flow Cytometry;Genetic;genetic approach;Genetic Transcription;Genetic Variation;Genotype;Growth;Heterogeneity;Homeostasis;Human;human disease;Immune response;Immunity;Immunology;Impairment;improved;Inbred Strains Mice;Inbreeding;Individual;individual response;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;insight;Lung;Macrophage;Massachusetts;medical schools;Mouse Strains;Mus;Mycobacterium tuberculosis;Myelogenous;novel strategies;novel therapeutic intervention;Outcome;pathogen;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Persons;Population;Population Heterogeneity;Predisposition;Production;programs;Proteins;pulmonary function;Recombinants;Regulation;Reproducibility;Research;Research Personnel;response;Role;Running;Scientist;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skills;Source;Stimulus;success;System;targeted treatment;Techniques;Technology;Testing;Therapeutic Intervention;therapy development;Tissues;tool;Training;Tuberculosis;Universities;Variant;Whole Organism

PROJECT_TITLE: Unfolded Protein Response Activation as a Determinant of the Host Response to M. tuberculosis


NIH_SPENDING_CATS: Biotechnology;Cancer;Orphan Drug;Prostate Cancer;Rare Diseases;Urologic Diseases

ORG_DEPT: PATHOLOGY

PHR: Project Narrative Current treatment options for neuroendocrine prostate cancer (NEPC), a highly aggressive subtype of prostate cancer, are only palliative, and most patients die within several months. It is therefore critical to identify therapeutically exploitable vulnerabilities for the preclinical testing of new drugs and drug combinations against NEPC. Our work will provide novel insights into the contributions of RB to ferroptosis as well as the preclinical data regarding efficacy, safety, and biomarkers required for the rationale design of future clinical trials that combine ferroptosis inducers and BCL2 inhibitors to treat lethal NEPC.

PI_NAMEs: CHEN, MING  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Adenocarcinoma Cell;Architecture;BCL2 gene;Biological Assay;Biological Markers;Biological Models;British Columbia;Castration;Cell Death;Cell Line;Cellular Assay;Cessation of life;Characteristics;Clinic;Clinical;Clinical Trials;Collaborations;combinatorial;cytotoxicity;Data;design;Development;Drug Combinations;Event;Future;Genetic;Genetically Engineered Mouse;Heterogeneity;hormone therapy;Human;Immunodeficient Mouse;implantation;In Vitro;in vivo;in vivo evaluation;inhibitor;insight;interdisciplinary approach;Iron;Lipid Peroxidation;loss of function;Lung Carcinoma;Malignant neoplasm of prostate;Malignant Neoplasms;Metastatic Prostate Cancer;Molecular;Neoplasm Metastasis;neuroendocrine differentiation;Neuroendocrine Prostate Cancer;Neuroendocrine Therapy;Neuroendocrine Tumors;novel;novel therapeutics;palliative;Pathway interactions;patient derived xenograft model;Patients;pre-clinical;preclinical study;Preclinical Testing;Prostate Adenocarcinoma;prostate cancer cell;prostate cancer model;Prostatic;RB1 gene;Research;Resistance;Retinoblastoma;Retinoblastoma Protein;Safety;screening;Small Cell Carcinoma;Specimen;targeted treatment;Testing;Therapeutic;Tissues;Translations;Treatment Efficacy;tumor;Universities;Validation;Visceral metastasis;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Developing A Novel Combinatorial Therapy for Lethal Neuroendocrine Prostate Cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Cancer;Machine Learning and Artificial Intelligence;Nanotechnology

ORG_CITY: GAINESVILLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE In the field of nanomedicine, there are many laboratory studies that have shown nanoparticle-based new drug formulations are effective in treating cancer in mice, but the translation of animal results to clinical success in humans is limited, in part, due to low delivery efficiency of nanoparticles to the tumor and lack of a robust computational model that can predict the tumor delivery efficiency of nanoparticles and extrapolate the results from animals to humans. This project is relevant to public health because the knowledge gained from the proposed research will improve our understanding of the key determinants of tissue distribution and tumor delivery of nanoparticles, which are essential for the design of effective nanomedicines. In addition, the proposed research will create a publicly available web-based interface that allows researchers to predict organ and tumor delivery efficiency of nanoparticles, thereby reducing or eliminating animal experimentation in nanomedicine studies and to accelerate clinical translation of nanoparticle-based anticancer drug formulations to benefit cancer patients.

PI_NAMEs: LIN, ZHOUMENG  (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: absorption;Acceleration;Accounting;Address;Animal Experimentation;Animals;Antineoplastic Agents;Artificial Intelligence;artificial intelligence method;Artificial nanoparticles;artificial neural network;Bayesian Analysis;Biodistribution;Breast Osteosarcoma;Cancer Patient;cancer therapy;Chemicals;Clinical;clinical translation;Computer Models;Data;Data Set;Databases;Dependence;design;Development;Diagnosis;Diameter;Dose;Drug Delivery Systems;Drug Formulations;Drug Kinetics;Drug or chemical Tissue Distribution;Drug Targeting;Ensure;Excretory function;Experimental Designs;experimental study;Female;Formulation;graphical user interface;Human;improved;interest;Knowledge;Laboratory Study;machine learning method;male;Malignant Breast Neoplasm;Malignant Neoplasms;Markov chain Monte Carlo methodology;Markov Chains;mathematical methods;Medical;Metabolism;Methods;Modeling;Mus;nano;nanoGold;nanomedicine;nanoparticle;nanoparticle delivery;Neural Network Simulation;novel;novel therapeutics;Online Systems;Organ;Outcome;Output;Parameter Estimation;pharmacokinetic model;Physiological;physiologically based pharmacokinetics;predictive modeling;Process;Property;Public Health;Publications;Publishing;Research;Research Personnel;Rodent;sex;Sex Differences;Site-Directed Mutagenesis;species difference;Statistical Methods;Subgroup;success;Technology;Testing;tool;Training;Translations;tumor;Uncertainty;user-friendly;web based interface;zeta potential

PROJECT_TITLE: Development of a web-based predictive model of nanoparticle delivery to tumors by integrating physiologically-based pharmacokinetic modeling with artificial intelligence

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

PI_NAMEs: DALDRUP-LINK, HEIKE ELIZABETH (contact)

PROJECT_TERMS: Address;Advanced Development;Advanced Malignant Neoplasm;Affect;Algorithms;anatomic imaging;Area;Artificial Intelligence;artificial intelligence algorithm;Automobile Driving;Basic Science;Biological Assay;Biological Markers;Blood;cancer biomarkers;Cancer Burden;Cancer Detection;cancer diagnosis;cancer imaging;cancer immunotherapy;cancer therapy;capsule;Catchment Area;Clinical;clinical imaging;clinical translation;Clinical Trials;Collaborations;Communities;computational intelligence;computer scientist;computerized data processing;data acquisition;Data Analyses;design;Detection;Development;Diagnosis;Diagnostic;Diagnostic Neoplasm Staging;Diagnostic Services;diagnostic technologies;diagnostic tool;Disease;Doctor of Philosophy;Early Diagnosis;Education;Education Projects;Educational process of instructing;Engineering;Ensure;Equipment;evidence base;experience;Faculty;Financial Support;Funding;Goals;Grant;Health;Human;Human Resources;Humanities;Image;image guided therapy;image reconstruction;imaging agent;imaging biomarker;imaging detection;Imaging Device;imaging facilities;imaging probe;imaging program;imaging study;Imaging Techniques;Imaging technology;improved;In Vitro;in vivo;in-vitro diagnostics;in-vivo diagnostics;innovation;Institution;instrument;instrumentation;interest;Leadership;Link;Magnetic Resonance Imaging;Malignant Neoplasms;Manuscripts;Medical Imaging;medical schools;Medicine;member;Michigan;molecular imaging;Molecular Target;Monitor;Monitoring Clinical Trials;nanoparticle;next generation;novel;novel diagnostics;novel strategies;Outcome;Patients;Peer Review;peer support;personalized care;personalized medicine;Pharmaceutical Preparations;Physicians;Positioning Attribute;Positron-Emission Tomography;pre-clinical;Precision Health;preclinical development;process improvement;programs;Publishing;Radiochemistry;recruit;Research;Research Peer Review;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Safety;Science;Scientist;screening;Screening for cancer;Serinus;Services;Speed;Staging;superresolution imaging;System;targeted imaging;Technology;Testing;theranostics;Therapeutic;tool;Training;Translational Research;tumor;tumor microenvironment;ultrasound;United States National Institutes of Health;Universities;Visualization;Wages

PROJECT_TITLE: Cancer Imaging & Early Detection


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Infectious Diseases

PI_NAMEs: DHINGRA, SOURABH  (contact)

PROJECT_TERMS: Affect;Allergic Bronchopulmonary Aspergillosis;anti-fungal agents;anti-microbial drug;Aspergillus fumigatus;Azole resistance;Azoles;Biochemical;Bioinformatics;Biology;Candida albicans;career development;Centers of Research Excellence;Clinical;clinically relevant;Data;Death Rate;design;Development;Disease Outcome;Disease Progression;drug development;Drug resistance;Drug Tolerance;Educational workshop;Fluorescent in Situ Hybridization;Foundations;Funding;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genomics;Goals;Growth;Human;human pathogen;Immune;improved;In Vitro;in vivo;Infection;innovation;insight;Itraconazole;Knowledge;Laboratories;Life;Literature;Lung infections;Measures;Mediating;Mentors;Messenger RNA;Microbe;Microbial Biofilms;Minimum Inhibitory Concentration measurement;Modeling;Molds;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;nano-string;Netherlands;novel;Outcome;pathogen;Pathogenesis;pathogenic fungus;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;posaconazole;posttranscriptional;Predisposition;prevent;Protocols documentation;Regulator Genes;Regulatory Pathway;Regulon;Research;Research Personnel;Resistance;resistant strain;response;Role;single molecule;Stress;Technology;Therapeutic;transcriptomics;Treatment Failure;Treatment outcome;treatment strategy;Universities;Untranslated RNA;Virulence;Voriconazole;Work

PROJECT_TITLE: Functional roles of ncRNA afu-182 in azole response and pathobiology of Aspergillus fumigatus


NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Fuchs’ corneal endothelial dystrophy occurs in nearly 4% of the United States population over the age of 40. With no proven medical treatment, this disorder is the leading indication for corneal transplantation in this country. A better understanding of the genetic basis of this disorder could lead to non-surgical treatments in the future.

PI_NAMEs: MOOTHA, VENKATESWARA VINOD (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Affect;Age;age related;Aging;aging related disease;Anterior;Antisense Oligonucleotides;Apoptosis;Aqueous Humor;autosome;Binding;biobank;Biology;Blindness;Blood;cell type;Cells;cohort;Cornea;Corneal Diseases;Corneal edema;Corneal Endothelium;corneal epithelium;Country;CUG repeat;Cultured Cells;Data;Defect;Degenerative Disorder;Disease;disease model;Disease Progression;DNA Repeat Expansion;DNA Sequence;Dominant-Negative Mutation;drug testing;Edema;empowerment;Endothelial Cells;Endothelium;Event;Expanded DNA Repeat;Extracellular Matrix;Extracellular Matrix Proteins;Fibrosis;Foundations;Fuchs' Endothelial Dystrophy;Future;gain of function;Gene Expression;Genes;Genetic;Genetic Transcription;genomic locus;Glaucoma;Histologic;Immune;in vivo;Inherited;Keratoplasty;knock-down;Knock-in;Laboratories;Lead;Length;Leukocytes;Link;Medical;Modeling;Molecular;mouse model;multidisciplinary;Mus;Myotonic Dystrophy;Neural Crest;Neurodegenerative Disorders;Nuclear;oligonucleotide therapeutics;Oligonucleotides;overexpression;Pathogenesis;Pathway interactions;Patients;PF4 Gene;Population;postmitotic;Pre-Clinical Model;precision medicine;premature;Prevalence;prevent;Primary Open Angle Glaucoma;Proteins;Publishing;recruit;Reporting;Resources;Risk;RNA;RNA Splicing;Role;Safety;Sampling;senescence;single-cell RNA sequencing;Somatic Mutation;Specificity;TCF4 haploinsufficiency;Testing;Therapeutic;therapeutic development;Tissues;Toxic effect;Trabecular meshwork structure;Transcript;Transcription Alteration;transcription factor;transcriptome;transcriptome sequencing;Trinucleotide Repeats;United States;Up-Regulation;Wild Type Mouse;Work

PROJECT_TITLE: Laying a Foundation for Precision Medicine for Fuchs' Dystrophy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Regenerative Medicine

ORG_CITY: RICHMOND

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Matrix vesicles, small extracellular vesicles released by osteoblasts and anchored in the extracellular matrix, are enriched with microRNA and other cell signaling molecules that may mediate bone development and regeneration. The role and mechanism of action of these matrix vesicles in mature bone remains to be elucidated, but may translate into therapeutic potential for orthopedic pathologies, including critical size bone defects and chronic nonunions. This study investigates the physical and chemical characteristics of matrix vesicles and their function with regard to cellular signaling pathway activation and new bone formation, with the ultimate goal of a novel therapeutic application to improve bone healing.

PI_NAMEs: SKELTON, ANNE MICHELLE (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Adult;Alkaline Phosphatase;Autologous;Binding;Biological;Biological Assay;Body System;bone;Bone Development;bone fracture repair;bone healing;Bone Marrow;Bone Regeneration;bone repair;Bone Transplantation;calcification;calcium phosphate;Cartilage;Cartilage Matrix;Cell Lineage;Cells;Characteristics;Chemicals;Chondrocytes;Chronic;Coculture Techniques;Collagen Fibril;Collagen Type I;Culture Media;Defect;Deposition;Differentiation Antigens;Embryo;Enzymes;Epiphysial cartilage;exosome;Experimental Models;Extracellular Matrix;extracellular vesicles;Femur;fetal;Foundations;Fracture;Goals;healing;Human body;Hybrid Cells;Hydrogels;Hydroxyapatites;improved;In Vitro;in vivo;in vivo Model;Injectable;Integrin Binding;intercellular communication;Lipids;Literature;long bone;Luciferases;Mature Bone;Measures;Mediating;Mediation;Membrane;microCT;MicroRNAs;mineralization;Minerals;Modeling;Morphology;mRNA Expression;Mus;nanoparticle;nanosized;novel therapeutics;Nucleic Acids;Operative Surgical Procedures;Organelles;Orthopedics;osteoblast differentiation;Osteoblasts;Osteocalcin;Osteogenesis;osteogenic;Pathology;Pathway interactions;Patients;Pattern;Phenotype;Phospholipids;Physiologic calcification;Physiologic Ossification;Play;Population;Population Heterogeneity;Process;Proliferating;Property;protein expression;Proteins;Regenerative Medicine;regenerative therapy;repaired;Research;response;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Site;standard care;Stromal Cells;success;System;Testing;Therapeutic;therapeutic evaluation;Tissues;Translating;Transmission Electron Microscopy;Trypsin;Untranslated RNA;Vesicle;vesicular release;Western Blotting

PROJECT_TITLE: Extracellular Matrix Vesicles and Intercellular Communication of Osteoblast-lineage Cells


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Gene Therapy;Genetics;Human Genome;Immunotherapy;Women's Health Research

PI_NAMEs: MACKALL, CRYSTAL  (contact)

PROJECT_TERMS: Acceleration;Adoptive Cell Transfers;Adult;Algorithms;Animal Model;anti-tumor immune response;Antibody Binding Sites;antibody conjugate;Antigens;antitumor effect;ATAC-seq;Basic Science;bench to bedside;bench-to-bedside translation;Biological;Biological Markers;Biopsy;Brain Neoplasms;cancer cell;Cancer Center;cancer clinical trial;cancer immunobiology;cancer immunotherapy;CAR T cell therapy;Catchment Area;Cell Therapy;Cells;Cellular immunotherapy;Characteristics;Child;Childhood;chimeric antigen receptor;chimeric antigen receptor T cells;Clinic;Clinical;clinical predictors;Clinical Research;Clinical Trials;Collaborations;Conduct Clinical Trials;Correlative Study;Cytometry;density;Development;Dimensions;Disease;Disseminated Malignant Neoplasm;Distant Metastasis;efficacy testing;exhaustion;experience;first-in-human;Flow Cytometry;Fostering;Functional disorder;fundamental research;Funding;Future;Glean;Goals;Grant;Grouping;Hematologic Neoplasms;high dimensionality;Human;Immune;immune function;Immune response;Immune system;Immune Targeting;Immune Tolerance;Immunologic Stimulation;Immunotherapy;improved;improved outcome;Industry;Infiltration;insight;Institution;large datasets;lymph nodes;Lymphocyte;Lymphoma;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Mediator;medical schools;member;Molecular;Multiplexed Ion Beam Imaging;Neoplasm Metastasis;neoplastic cell;new technology;next generation;next generation sequencing;Noninfiltrating Intraductal Carcinoma;novel;novel marker;novel therapeutics;Orphan;Paper;Participant;Pathway interactions;Patients;Peer Review;Peptide Receptor;Peptides;predictive marker;prevent;programs;Property;Protein Analysis;Proteins;Publishing;rational design;recruit;refractory cancer;Regimen;Research;Research Personnel;Resistance;resistance mechanism;Resource Sharing;response biomarker;Sampling;Science;Scientist;single cell technology;Solid Neoplasm;Source;Specificity;T cell receptor repertoire sequencing;T cell therapy;T-Cell Receptor;T-Lymphocyte;Technology;Therapeutic;Tissues;Toxic effect;Translating;translational cancer research;Translational Research;Translations;tumor;Tumor Immunity;tumor microenvironment;tumor progression;United States National Institutes of Health;Woman;Work;Yeasts

PROJECT_TITLE: Cancer Immunotherapy


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Increases in the number of biomedical PhD graduates from underrepresented backgrounds has not resulted in more diversity at the faculty level. Departure from academic paths at the postdoc level is partly responsible. The Yale Ciencia Academy will ensure that students from underrepresented backgrounds persist in academic paths by providing peer and role model communities of support connected across geographic distances and by training students in career planning, mentoring, and communication skills with a focus on the PhD to postdoc transition.

PI_NAMEs: COLON-RAMOS, DANIEL A;GUERRERO-MEDINA, GIOVANNA  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Academy;Address;Affect;Area;career;career development;Career Mobility;career networking;case control;cohort;Communication;Communication difficulty;Communities;design;Development;Development Plans;Disadvantaged;Doctor of Philosophy;doctoral student;Educational Intervention;empowerment;Enrollment;Ensure;Environment;expectation;experience;Faculty;Feedback;Female;Future;Geography;Goals;Grant;improved;Individual;interest;Intervention;Interview;Knowledge;Laboratory Research;Learning;Measurable;meetings;Mentors;minority scientist;Modeling;Outcome;Participant;peer;peer coaching;peer networks;peer support;Personal Communication;personal narratives;Persons;Phase;Positioning Attribute;Postdoctoral Fellow;Preparation;Productivity;Program Development;programs;racial bias;Readiness;recruit;Research;Research Personnel;Role;role model;Science;Scientist;Secure;Self Efficacy;Sex Bias;skill acquisition;skills;student training;Students;success;support network;Support System;System;tenure track;Testing;Training;Training Support;Underrepresented Minority;underrepresented minority student;Underrepresented Students;Writing

PROJECT_TITLE: The Yale Ciencia Academy: Enhancing Biomedical Training and Diversity Through a Peer & Role Model Professional Development Program


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases;Orphan Drug;Rare Diseases;Sexually Transmitted Infections;Vector-Borne Diseases

PI_NAMEs: WHITEHEAD, DANIEL CHARLES (contact)

PROJECT_TERMS: Africa South of the Sahara;African Trypanosomiasis;Alkynes;analog;Antiparasitic Agents;Area;Biological;Cells;cellular targeting;Centers of Research Excellence;Chagas Disease;Chemistry;Collaborations;cycloaddition;cytotoxicity;Data;Development;Disease;Electrons;Ethers;Evaluation;Exhibits;fexinidazole;Future;Genes;genetic approach;Goals;high throughput screening;Human;infection risk;innovation;Label;Laboratories;Leishmania;Leishmaniasis;Libraries;Mammalian Cell;Methodology;Morphology;neglected tropical diseases;novel;novel therapeutic intervention;Organic Chemistry;Organism;overexpression;Parasites;Parasitic infection;pathogen;Pharmaceutical Preparations;Principal Investigator;programs;Proteomics;Reaction;Resistance;RNA Interference;Route;screening;Sexually Transmitted Diseases;side effect;Structure-Activity Relationship;Testing;Therapeutic;Toxic effect;Trichomonas;Trichomonas vaginalis;Trypanosoma;Trypanosoma brucei brucei;Trypanosoma cruzi;United States


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Precision Medicine;Women's Health Research

PI_NAMEs: GRAY, NATHANAEL SCHIANDER (contact)

PROJECT_TERMS: Acceleration;Advanced Development;Area;Basic Science;Biological Markers;biomarker development;biomarker validation;Bladder;cancer clinical trial;Cancer Patient;cancer therapy;Catchment Area;cell free DNA;Chemicals;Clinic;Clinical;clinical application;clinical development;Clinical Sciences;clinical translation;Clinical Trials;Clinical Trials Network;Collaborations;Conduct Clinical Trials;Contrast Media;Core Facility;CRISPR/Cas technology;design;Development;Diagnosis;Diagnosis Clinical Trials;diagnostic biomarker;diagnostic strategy;Doctor of Philosophy;Drug Combinations;Drug Delivery Systems;drug development;drug discovery;Evaluation;experience;Fostering;Funding;Future;Goals;Head and neck structure;Health;Human;improved;innovation;Institution;Investigational Therapies;Investments;Label;Laboratories;Leadership;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Manuscripts;Medical;Medicine;member;migration;molecular diagnostics;molecular marker;molecular oncology;nanoimmunoassay;New Agents;new technology;new therapeutic target;novel;novel diagnostics;novel strategies;novel therapeutics;oncology program;Peer Review;peer support;Pharmaceutical Chemistry;Phase;phase III trial;pre-clinical;Prognosis;Program Development;programs;Proteins;Publishing;recruit;Renal Carcinoma;Research;Research Peer Review;Research Personnel;Schools;Science;sensor;small molecule therapeutics;Solid Neoplasm;Strategic Planning;Surgical margins;Talents;Technology;Testing;Therapeutic;Therapeutic Agents;therapeutic biomarker;Therapy Clinical Trials;therapy outcome;Translating;Translational Research;Translations;tumor;United States National Institutes of Health;Universities

PROJECT_TITLE: Cancer Therapeutics


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Circulatory shock is a major cause of morbidity and mortality among critically ill patients. Early identification or forecasting of shock would be clinically actionable and improve prognosis, but no personalized prediction model for shock has been presented yet. We propose to develop physiologically and clinically relevant machine learning-based prediction models and therapeutic strategies that could guide personalized diagnosis and treatment of circulatory shock.

PI_NAMEs: YOON, JOO HEUNG  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TERMS: Acute;Adverse event;adverse event risk;adverse outcome;Algorithms;alternative treatment;analog;Artificial Intelligence;Award;Bioinformatics;biomedical informatics;Blood Donations;Blood donor;Blood flow;Blood Pressure;Cardiovascular system;career;causal model;Characteristics;Clinical;Clinical Data;Clinical Informatics;Clinical Research;Clinical Trials;clinically actionable;clinically relevant;cohort;Compensation;Complex;computer science;computer scientist;computerized data processing;Computerized Medical Record;Critical Care;Critical Illness;Data;data acquisition;Data Analyses;Data Science;Data Set;Databases;deep learning;density;Detection;Development;Distress;Early Diagnosis;Early identification;Electrocardiogram;Electroconvulsive Therapy;Ensure;Environment;Evolution;Failure;Family suidae;Goals;Grant;Health Care Costs;hemodynamics;Hemoglobin concentration result;Hemorrhage;Heterogeneity;high risk;human subject;Hypersensitivity;Hypotension;Hypovolemia;Hypovolemics;improved;improved outcome;Individual;individualized medicine;Information Sciences;Intensive Care Units;Interdisciplinary Study;K-Series Research Career Programs;Learning;Life;Link;Liquid substance;Lung;Machine Learning;machine learning algorithm;machine learning model;machine learning prediction;Master of Science;Measures;Medicine;Mentors;Metabolic;Modeling;Morbidity - disease rate;mortality;Nature;neurotensin mimic 2;Organ;Outcome;Oxygen;Patients;Pattern;personalized diagnostics;personalized medicine;personalized predictions;Phenotype;Photoplethysmography;Physicians;Physiological;Physiology;Plethysmography;Predictive Analytics;predictive modeling;Probability;Prognosis;progression risk;Psychological reinforcement;Reaction;Reporting;Research;Research Methodology;response;Resuscitation;Risk;Scientist;Series;Severities;Severity of illness;Shock;signal processing;skills;supervised learning;Tachycardia;Therapeutic;Time;Training;Treatment Protocols;treatment strategy;Universities;unsupervised learning;Vasoconstrictor Agents;volunteer;Work

PROJECT_TITLE: Developing Machine Learning-Driven Prediction Models and Therapeutic Strategies for Circulatory Shock in Critically-ill Patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-W(90)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: STAMATIKOS, ALEXIS  (contact)

PROJECT_TERMS: Adverse effects;African Trypanosomiasis;Anti-Inflammatory Agents;ATP binding cassette transporter 1;Centers of Research Excellence;Cessation of life;Cholesterol;Disease;Human;Immune response;Infection;Inflammatory;innovation;Left;Mediating;Membrane Microdomains;neglected tropical diseases;Parasites;pathogen;Patients;Process;side effect;Toll-like receptors;Trypanosoma brucei brucei;Virulence

PROJECT_TITLE: Assessing the impact of ABCA1 and ABCG1 expression on T. brucei infection


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: LEVY, RONALD  (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;Anti-CD47;Antibodies;Area;Attention;Basic Science;bioinformatics tool;Biological;Biological Assay;Biological Markers;Biology;Blood;Bone Marrow Transplantation;Cancer Biology;Cancer Center Support Grant;cancer immunotherapy;Cancer Personalized Profiling by Deep Sequencing;cancer stem cell;cancer therapy;cancer vaccination;CAR T cell therapy;Categories;Cells;Chemistry;chronic graft versus host disease;Chronic Lymphocytic Leukemia;Clinic;Clinical;Clinical Investigator;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Cooperative Group;Clinical Trials Design;cohort;Collaborations;Cutaneous T-cell lymphoma;cytotoxic;Data;Detection;Development;Diagnosis;Diagnostic;Disease;Dysmyelopoietic Syndromes;early phase clinical trial;effective therapy;Epigenetic Process;Event;Evolution;Flow Cytometry;Funding;Future;Gene Expression;Genomics;Genotype;Goals;Hematologic Neoplasms;Heterogeneity;high dimensionality;Humanities;Immune checkpoint inhibitor;Immune system;Immunologics;Immunotherapy;improved;in situ vaccination;in vivo;insight;Institution;Investigation;Journals;Knowledge;Laboratories;Laboratory Study;large cell Diffuse non-Hodgkin's lymphoma;Lead;leukemic stem cell;liquid biopsy;Lymphomagenesis;Malignant Neoplasms;Measurable;Measurement;medical schools;member;Metabolic;Methods;Modification;Molecular;Monitor;Monoclonal Antibodies;mRNA delivery;multidimensional data;Mutation;MYC gene;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Participant;participant enrollment;Pathogenesis;Patient-Focused Outcomes;Patients;Peer Review;peer support;Population Sciences;preclinical study;Prognosis;programs;protein protein interaction;Proteomics;Publications;Publishing;Regimen;Research;Research Peer Review;Residual Neoplasm;RNA;Role;Schools;Science;Signal Pathway;single cell analysis;single cell technology;Source;Specimen;targeted agent;Technology;Therapeutic;Tissues;tool;Translational Research;tumor DNA;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Hematologic Malignancies


NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Legionella pneumophila (Lp) causes a potentially fatal form of pneumonia known as Legionnaires’ disease and is an intracellular parasite of amoebae when it is in water systems or macrophages when inhaled into the lungs. The Cianciotto lab has determined that a type II secretion system (T2SS) is required for Lp growth in amoebae, human macrophages, and the murine lung. The protein substrates that are secreted by the T2SS are important to our understanding of pathogenesis and potential targets for disease diagnosis or prevention, and hence, this proposal aims to determine how a novel T2SS-dependent deacetylase that is well conserved within the Legionella genus promotes the persistence and spread of the Lp pathogen.

PI_NAMEs: ADAMS, CARLTON  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Acanthameba infection;Acanthamoeba castellanii;Acetates;Amoeba genus;Bioinformatics;built environment;Cellulose;Chitin;contaminated water;Deacetylase;Deacetylation;Defect;Dependence;disease diagnosis;disorder prevention;Doctor of Philosophy;Education;enzyme activity;exoenzyme;extracellular;Family;Fellowship;Goals;Growth;Health;Human;human disease;in silico;Incidence;Individual;Individual National Research Service Award;Infection;Inhalation;Knowledge;Learning;Legionella;Legionella pneumophila;Legionnaires' Disease;Life Cycle Stages;Link;Locales;Lung;Macrophage;Mediating;Microbial Biofilms;Muramidase;Mus;mutant;Nature;novel;Parasites;pathogen;Pathogenesis;Pathway interactions;Peptide Signal Sequences;Peptidoglycan;Phase;Pneumonia;polysaccharide deacetylase;Polysaccharides;pre-doctoral;Prevalence;prevent;Protein Secretion;Proteins;Proteomics;Research;Role;Scientist;Surface;System;Training;trait;Type II Secretion System Pathway;Water;Western Blotting;Work;Xylans

PROJECT_TITLE: Importance and function of highly conserved substrates of the Legionella pneumophila Type II Secretion System for Infection


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Obesity;Palliative Care;Physical Activity;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: JOHN, ESTHER M. (contact)

PROJECT_TERMS: Address;adverse outcome;Age;Applications Grants;behavior change;Behavioral;Behavioral Sciences;Big Data;Bioinformatics;Body Composition;brca gene;Breast;Breast Cancer Genetics;Cancer Burden;cancer care;Cancer Etiology;cancer health disparity;Cancer health equity;Cancer Patient;cancer prevention;cancer risk;cancer therapy;Caregivers;Catchment Area;Clinical;clinical care;clinical decision-making;clinical development;clinical practice;Clinical Sciences;Collaborations;Collection;Colon;Communication;Communities;community engagement;Community Health;Community Outreach;comorbidity;computed tomography screening;Computerized Medical Record;cost effective;COVID-19 complications;data mining;data resource;Data Set;Detection;Diagnosis;Diet;Disease Progression;Effectiveness;efficacy testing;end of life;end of life care;Environmental Exposure;Epidemiology;Ethnic Origin;Etiology;Faculty;Family Cancer History;Funding;Future;Gender;Genes;Genetic;genetic epidemiology;Genetic Risk;genetic risk assessment;genetic testing;Geography;Goals;Grant;Guidelines;Health;Health Policy;Health Services;high risk population;implementation science;improved;improved outcome;Incidence;innovation;Institution;International;Intervention;Intervention Studies;Intervention Trial;Journals;K-Series Research Career Programs;Lead;Leadership;Legal;Life Cycle Stages;life span;Life Style;lifestyle intervention;Liver;Lung;Lymphoma;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Manuscripts;Medicare;member;Mentors;Metabolic;Methods;Minor;Mobile Health Application;Modeling;Molecular;Morbidity - disease rate;mortality;multidisciplinary;NCI-Designated Cancer Center;Neoplasm Metastasis;new technology;next generation;nicotine use;novel;Obesity;Observational Study;Outcome;Palliative Care;Pancreas;Pathogenicity;Patients;Peer Review;peer support;personalized approach;Physical activity;Population;Population Heterogeneity;Population Sciences;Practice Guidelines;pre-clinical;Prevention;Prevention Research;Prognostic Factor;programs;Prostate;Public Health;Publishing;Quality of life;Race;recruit;Rectum;Recurrence;Research;Research Personnel;Research Priority;Resource Sharing;Risk Factors;risk prediction;risk prediction model;Risk Reduction;Sales;Scientist;screening;Screening for cancer;Second Primary Cancers;sedentary;sex;Sexual and Gender Minorities;Shapes;Sleep;social determinants;social health determinants;Socioeconomic Status;Stress;survivorship;Symptom Burden;Testing;Tobacco;tobacco control;tobacco products;Tobacco use;tobacco user;Training;Training Programs;Translational Research;Treatment Factor;treatment response;United States National Institutes of Health;Variant;working group

PROJECT_TITLE: Population Sciences


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: This is a novel study focused on designing and testing an implementation strategy bundle, Rapid Adaptation to Prevent Drug use (RAPD). RAPD will help optimize the capacity of schools respond to emerging drug use issues by reflecting on gaps and best practices from previous responses (e.g., vaping), including inequities in responsiveness. This research will enhance the public health impact of existing evidence-based interventions, enhance equity and enable similar adaptations of future emerging drug use issues.

PI_NAMEs: EISMAN, ANDRIA B (contact)

PROGRAM_OFFICER_NAME: MITCHELL, SHANNON GWIN

PROJECT_TERMS: academic standard;Address;Adolescent;Adopted;Attention;Communities;comparative;cost;Cost Analysis;cost effectiveness;Costs and Benefits;COVID-19;Data;design;Disparity;drug abuse prevention;drug misuse;drug standard;Drug usage;Early Intervention;economic evaluation;Educational Curriculum;Effectiveness;Equity;Event;evidence base;Evidence based intervention;Family;Foundations;Future;Goals;Health;Health behavior;Health education;Health system;Health trends;Hybrids;implementation evaluation;implementation outcomes;implementation science;implementation strategy;improved;Inequity;Infrastructure;innovation;Intervention;Low income;marginalization;Methods;Michigan;Modeling;Morbidity - disease rate;mortality;multiple drug use;novel;novel therapeutics;Outcome;Pharmaceutical Preparations;Phase;pilot test;Population;Poverty;Prevention;Process;programs;Public Health;rapid test;rapid testing;Recording of previous events;Reporting;Research;Research Proposals;Resources;response;Risk;risk perception;Schools;Shapes;skills;Societies;stakeholder perspectives;stem;Students;Substance Use Disorder;Support System;System;teacher;Testing;Training;Trauma;trend;Update;vaping;Youth

PROJECT_TITLE: Enhancing the Impact of Evidence-Based Prevention for Youth: The Rapid Adaption to Prevent Drug Use (RAPD) Implementation Strategy

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: ADAMS, ALYCE SOPHIA (contact)

PROJECT_TERMS: Address;Advocacy;Advocate;African American;Age;anti-cancer research;Area;Asian;Behavioral;Black race;Breast;Cancer Burden;cancer care;cancer clinical trial;Cancer Control;cancer health disparity;Cancer health equity;cancer prevention;cancer risk;care systems;Catchment Area;Child Health;Clinical Research;clinical trial recruitment;Clinical Trials;Collaborations;Colon;Communication;Communities;community advisory board;community based participatory research;community collaboration;community engagement;Community Health;community organizations;Community Outreach;community partners;community partnership;County;cultural competence;dashboard;Data Analytics;design;Doctor of Philosophy;Education;Education and Outreach;Ethnic Origin;Evaluation;evidence base;Faculty;Funding;Future;Geography;health equity;health equity promotion;Health equity research;health inequalities;Healthcare;high risk;Immigrant;improved;Incidence;Infrastructure;innovation;International;Latinx;Leadership;Lesbian Gay Bisexual Transgender Queer;life span;Liver;Lung;Lymphoma;Malignant Neoplasms;medical schools;Melanoma;member;minority patient;Monitor;mortality;Obesity;Pacific Islander;Pancreas;patient navigation;patient oriented;Patients;Persons;Policies;Population Density;Prevention;Prostate;Race;recruit;Research;Research Priority;Research Project Grants;research to practice;response;Risk Factors;San Francisco;Services;Subgroup;tobacco control;tobacco prevention;Tobacco use;tool;Training;Translating;Translations;Underrepresented Minority;Underserved Population;Universities;Work

PROJECT_TITLE: Community Outreach and Engagement


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

PHR: The Carcinogenesis Program provides a diverse group of exceptional pre-doctoral students at Northwestern University with the conceptual foundation, laboratory experience, and operational skills they need to establish careers dedicated to improving cancer diagnosis, prevention, and treatment. Preceptors (mentors) bring interdisciplinary expertise ranging from fundamental cancer biology to cutting edge strategies for drug delivery. The training program integrates a dynamic didactic and career development curriculum with training at the laboratory bench to prepare students for cancer research careers.

PI_NAMEs: GREEN, KATHLEEN JANEE (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: carcinogenesis;Training Programs

PROJECT_TITLE: Carcinogenesis Training Program

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]