NIH_SPENDING_CATS: Bioengineering;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

PI_NAMEs: DASGUPTA, SAYAN  (contact)

PROJECT_TERMS: Address;Age;Algorithms;Appointment;automated visual evaluation;Bioinformatics;Biometry;cancer prevention;Caribbean region;cervical cancer prevention;Child;clinical center;Clinical Data;clinical database;Clinical Trials;Clinical Trials Unit;co-clinical trial;Collaborations;collaborative environment;Colposcopy;Communicable Diseases;Data;Data Collection;data management;Data Management Resources;design;Dominican Republic;Dose;electronic data;Enrollment;Ensure;Epidemiology;flexibility;Goals;Health Sciences;HIV;HIV/AIDS;HPV E7;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immune;immunogenicity;Immunotherapy;improved;Individual;Information Dissemination;Infrastructure;innovation;International;Interruption;Latin America;Leadership;Lesion;Malignant neoplasm of cervix uteri;member;Methods;Mission;Monitor;new technology;Operative Surgical Procedures;Pap smear;Papillomavirus Transforming Protein E6;Persons;Peru;Physical environment;Play;point of care;Politics;premalignant;Prevention;Prevention Research;Preventive Medicine;primary endpoint;professor;programs;Public Health;Publications;Reporting;Research;Resource-limited setting;response;Role;Safety;Schedule;Science;Scientific Advances and Accomplishments;screening;secondary endpoint;Secure;Security;Services;Sirolimus;standard of care;statistical center;Statistical Data Interpretation;Statistical Methods;Testing;Time;tool;treatment strategy;Triage;trial design;Universities;Vaccination;Vaccines;Visual;Vulnerable Populations;Washington;Woman;women's diagnosis;Work;Youth

PROJECT_TITLE: Data Management and Statistical Core


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PI_NAMEs: CARTER, JOSEPH JOHN (contact)

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Anatomy;Anogenital cancer;anti-tumor immune response;Antibodies;Award;Binding;Biological;Biological Assay;Biological Specimen Banks;biomarker development;Biopsy;Blood specimen;Board Certification;cancer prevention;Cells;Cervical;Clinical Data;clinically relevant;Collection;Communication;Complex;Correlative Study;DNA Viruses;Drug or chemical Tissue Distribution;Ensure;epidemiology study;experience;Fred Hutchinson Cancer Research Center;Future;Genotype;Grant;high risk;Histology;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human Resources;Immune;Immune Tolerance;Immunohistochemistry;Immunooncology;immunopathology;Industry;Institution;Laboratories;laboratory experience;Laboratory Research;Laboratory Scientists;Laboratory Study;Leadership;Malignant Neoplasms;Memory B-Lymphocyte;Mission;Names;Papillomavirus;Pathologist;Pathology;Peripheral Blood Mononuclear Cell;Phenotype;Play;predicting response;Procedures;Protocols documentation;quality assurance;Quality Control;Recurrence;Research Personnel;Resource Sharing;response;Role;Running;Sampling;Sampling Studies;Serology test;Services;Shipping;Site;Specific qualifier value;Specimen;Stress;Techniques;Technology Transfer;Testing;Tissue Banks;Tissue Sample;Tissues;Training;tumor;tumor microenvironment;Work

PROJECT_TITLE: Central Laboratory Core


NIH_SPENDING_CATS: Bioengineering;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

PI_NAMEs: CABELLO, ROBINSON ;DUERR, ANN C;MADELEINE, MARGARET M (contact)

PROJECT_TERMS: Acetic Acids;Address;Age;Algorithms;automated visual evaluation;cancer prevention;Caribbean region;Cervical;cervical cancer prevention;Cervical Cancer Screening;Cessation of life;Child;Clinical Trials;Colposcopy;Communities;Detection;Diagnosis;Disproportionately impacts women;Dominican Republic;Dose;Enrollment;experience;Goals;Health;high risk;HIV;HIV Infections;HPV E7;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Imaging technology;Immune;Immunoprevention;implementation facilitation;Improve Access;improved;improved outcome;Incidence;Infrastructure;International;Latin America;Lesion;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Methods;new technology;Operative Surgical Procedures;overtreatment;Pap smear;Papillomavirus Transforming Protein E6;Patients;Persons;Peru;point of care;Population;Populations at Risk;premalignant;prevent;Prevention;programs;progression risk;Provider;Quality of life;Research;Resources;response;Schedule;screening;Sirolimus;Site;standard of care;Testing;Time;treatment strategy;Triage;Vaccination;Visual;Woman;Youth


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE – PUBLIC HEALTH RELEVANCE The Clinic-based Multicenter ALS Natural History Data Collection provides critical information about medical history, ALS subtypes, and ALS progression in study participants. The project is deliberately inclusive so as to provide information that is as representative as possible of all people living with ALS. This information will be used by scientists, clinicians, and drug developers to help them improve care, design clinical trials, and assess outcomes in all people living with ALS.

PI_NAMEs: WALK, DAVID  (contact)

PROGRAM_OFFICER_NAME: XU, LEI


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Dissemination and Implementation Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Environmental exposures profoundly shape lifespan health and disease trajectories. The ECHO Measurement Core will advise, orchestrate, and frame the coordinated, sensitive measurement of exposures, developmental processes, and health outcomes central to achieving ECHO's objective of mapping the impact of early exposures on child health and development. We will develop and refine measures for the ECHO Cohort Protocol (ECP), including methods to implement the measures that are culturally sensitive and valid for diverse populations, assist the ECHO Consortium in implementing and evaluating the ECP, and we will lead strategic decision-making and operational strategies to incorporate new and revised measures to advance ECHO Cohort science while minimizing participant and staff burden.

PI_NAMEs: CELLA, DAVID  (contact);GERSHON, RICHARD

PROGRAM_OFFICER_NAME: MASH, CLAY

PROJECT_TERMS: Adoption;Adult;Brain;Child Development;Child Health;Clinical Research;cohort;Cohort Studies;Collaborations;Collection;Communication;Computers;Conceptions;Data;Data Analyses;Data Collection;Data Element;data harmonization;Decision Making;Dedications;Detection;Development;Developmental Process;Disease;Ensure;Environmental Exposure;Environmental Risk Factor;flexibility;Foundations;Goals;Health;implementation fidelity;implementation strategy;improved;innovation;instrument;Investigation;Lead;life span;Link;Manuals;Maps;Measurement;Measures;Methods;mindfulness;Monitor;neurodevelopment;novel;Obesity;Outcome;Participant;participant retention;Perinatal Exposure;Personal Satisfaction;Persons;Population Heterogeneity;postnatal;preclinical study;Predisposition;Procedures;Process;Protocols documentation;Psychometrics;Public Health;Publications;remote assessment;Reproducibility;Resources;Respondent;Risk;Science;Scientist;Shapes;Site;sound;Specific qualifier value;Standardization;standardize measure;Structure;Support System;System;Technology;Testing;Time;Training;Visit;wearable sensor technology;Work

PROJECT_TITLE: The ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-G(51)R]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Networking and Information Technology R&D (NITRD);Nutrition;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE High dietary sodium intake is linked to incident hypertension (HTN) and cardiovascular events. Conversely, lower sodium intake has been shown to reduce both blood pressure (BP) and prevent atherosclerotic cardiovascular diseases (ASCVD). American Heart Association guidelines advocate daily sodium intake of less than 2,300 mg, but the estimated average sodium intake for Americans is 3,400 mg per day. In recent years, consumption of pre-processed and restaurant foods has substantially increased, and more than 75% of sodium in the average U.S. diet now comes from these sources. Our overall objectives are to: (1) evaluate the efficacy of a dietary sodium mobile application intervention on reducing BP, (2) establish that the improvement in BP is directly related to the change in diet and body weight, and (3) optimize the intervention to demonstrate sustained effects on BP.

PI_NAMEs: DORSCH, MICHAEL  (contact);NALLAMOTHU, BRAHMAJEE K

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: adaptive intervention;Adherence;Advocate;American;American Heart Association;Atherosclerosis;Blood Pressure;blood pressure reduction;Body Weight;Calories;Cardiovascular system;Chronic;Clinical;Consumption;Data;Development;Diagnosis;Diet;dietary;Dietary Component;Dietary Sodium;digital health;Disease;Education;efficacy evaluation;Electronic Health Record;Event;Food;Fostering;Future;Goals;group intervention;Guidelines;habituation;Health behavior;Home;Home Blood Pressure Monitoring;Hypertension;hypertensive;improved;Intake;Intervention;intervention effect;Knowledge;Learning;Life Style;Link;Measures;Mediating;Mediator;Medicine;Michigan;mobile application;Morbidity - disease rate;Notification;novel;nutrition;Participant;participant enrollment;patient engagement;Patient Recruitments;Patients;Potassium;prevent;Probability;Process;programs;prospective;Psychological reinforcement;Randomized;randomized trial;Randomized, Controlled Trials;Research;Restaurants;Self Management;Sodium;Sodium-Restricted Diet;Source;Technology;Testing;theories;Time;tool;trend;wearable device;wireless;Work

PROJECT_TITLE: A Just-In-Time Adaptive Mobile Application Intervention To Reduce Sodium Intake And Blood Pressure In Hypertensive Patients

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(MA)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Correlating structural changes in the region of the brain caused by cognitive impairment with those in shape and molecular in the same region will be important for understanding cognition in aging. In turn, this may help to understand pathological changes associated with cognitive impairment. Such analysis is challenging and can be analyzed by powerful tools that consistently preserve information across scales from the macroscopic one of magnetic resonance scans to the microscopic scales of histologic images and molecular changes.

PI_NAMEs: MILLER, MICHAEL I (contact);MORRIS, MEAGHAN O'MALLEY

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: 3-Dimensional;abeta deposition;Affect;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer’s disease biomarker;American;Amyloid beta-Protein;Anatomy;Area;Atlases;Atrophic;Autopsy;Biological;Brain;Brain region;cell type;Cells;cerebral atrophy;Chronic Disease;Clinical;Cognition;Cognitive;Dementia;Development;digital;Disease;Disease Progression;entorhinal cortex;Exhibits;experience;Future;Gene Expression;Gene Expression Profile;Genetic Transcription;Goals;Histologic;histological image;Image;Impaired cognition;in vivo;indexing;Individual;insight;Investigation;Knowledge;Lateral;Learning;Lesion;Link;Location;Longitudinal Studies;Machine Learning;Magnetic Resonance;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Measures;Medial;medial temporal lobe;Memory;meter;Microscopic;mild cognitive impairment;millimeter;minimally invasive;Molecular;Molecular Profiling;morphometry;MRI Scans;Neurites;Neurobehavioral Manifestations;Neurofibrillary Tangles;Neurons;neuropathology;novel;Outcome;Pathologic;Pathology;Pattern;Population;population based;Positioning Attribute;Postmortem Changes;pre-clinical;Predisposition;preservation;progression marker;Protocols documentation;reconstruction;regional atrophy;Scanning;Shapes;Spatial Distribution;Staging;Symptoms;System;tau aggregation;tau Proteins;Technology;Temporal Lobe;Testing;Thick;Time;tool;transcriptome;transcriptomics;Work

PROJECT_TITLE: Multi-scale MRI-based Diffeomorphometry of Pathology and Molecular Signatures Associated with Entorhinal Cortex Atrophy in Alzheimer's Disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: LEXINGTON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), the causative agent of the Covid-19 pandemic, infects the host cell by binding its spike protein with the angiotensin-converting enzyme 2 (ACE2) on the host receptor cells. Structurally, spike protein has two subunits, S1 and S2, and is a trimer, while the ACE2 protein is a homodimer; however, critical questions about the dynamics of the molecular interactions to activate the membrane fusion remain. This project will determine the dynamics of each molecular interaction associated with the SARS-CoV-2 entry, thus helping to design more effective countermeasures.

PI_NAMEs: SHRESTHA, PRAKASH  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TITLE: Understand the mechanism of SARS-CoV-2 entry by single-molecule approaches

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

ORG_STATE: CA

PI_NAMEs: ZUNIGA DE NUNCIO, MARIA LUISA (contact)

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Academia;Academy;Acceleration;Achievement;addiction;Address;Area;Biomedical Research;career;career life balance;Climate;cohort;college;Communities;community building;community engaged research;Community Networks;community partners;Coupled;curriculum development;Dedications;Development Plans;Disparity;Diverse Workforce;Educational Curriculum;Ensure;Environment;Environmental Health;Equity;equity, diversity, and inclusion;ethnic minority;Event;evidence base;Faculty;faculty community;faculty mentor;faculty research;faculty support;Fostering;Funding;Geography;Goals;Grant;Growth;Health;health disparity;Health Sciences;Human;implementation science;improved;Individual;Institution;Intervention;Knowledge;Latinx;Leadership;Life;Longitudinal cohort;Manuscripts;Mediation;member;Mentors;Mentorship;Mexico;Mind;Minority Health Research;minority scientist;model development;Modeling;Nutritional Study;Obesity;peer;peer coaching;peer networks;Personal Satisfaction;Persons;Physical activity;Positioning Attribute;Privatization;Productivity;programs;racial minority;Recommendation;recruit;Reporting;Research;research and development;research faculty;Research Personnel;Research Training;Resource Development;Resources;retention rate;Role;satisfaction;Schools;Science;Seasons;Self Efficacy;senior faculty;Services;skill acquisition;skills;Spanish;Structure;success;Syndrome;Teacher Professional Development;Time;tool;Training;Training Programs;Underrepresented Minority;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: SDSU FUERTE: Faculty Development Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1]


ACTIVITY: ZIA

ADMINISTERING_IC: AA

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Microbiome;Neurosciences;Nutrition;Prevention;Substance Misuse

PI_NAMEs: JOSEPH, PAULE  (contact)

PROJECT_TERMS: Affect;Alcohol abuse;Alcohol consumption;alcohol use disorder;Alcohols;Area;Behavior;Biological;Biological Markers;Blood;chronic alcohol ingestion;Clinic;clinical center;Collaborations;comorbidity;Data Collection;design;Development;disorder risk;Enrollment;Equipment and Supplies;Esthesia;exosome;experience;falls;Future;Genotype;gut microbiota;Hour;Human;Impairment;improved;Individual;individual variation;Inflammation;inflammatory marker;innovation;Institutional Review Boards;Measures;Metabolic hormone;microbiome composition;microbiota;National Institute on Alcohol Abuse and Alcoholism;Natural History;Neurons;Nose;operation;oral microbiome;Participant;Perception;Phenotype;prevent;primary endpoint;Public Health;recruit;Reporting;Research;Risk Factors;Saliva;Salivary;Sampling;screening;secondary endpoint;Sensory;sensory system;Series;Shapes;Signal Transduction;Smell Perception;System;Taste Perception;Testing;Texture;tool;Training;United States National Institutes of Health;Variant;Visit

PROJECT_TITLE: Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Diabetes;Digestive Diseases;Microbiome;Nutrition;Obesity;Prevention;Substance Misuse

ORG_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

PROJECT_TERMS: absorption;Adult;Affect;Age Years;Animals;bariatric surgery;Body Composition;Body Weight decreased;Caffeine;Carbonates;Cardiovascular Diseases;Child;Consumption;Cross-Sectional Studies;Data;Diabetes Mellitus;Diet;Dose;Energy Intake;Enteroendocrine Cell;Family;fatty liver disease;Gastrointestinal tract structure;glucagon-like peptide 1;Glucose;Glucose Transporter;GLUT-2 protein;gut microbiome;Gut Mucosa;healthy volunteer;Hormones;Human;Human Milk;impaired glucose tolerance;Individual;Infant;inhibitor;Insulin Resistance;insulin secretion;Intake;Intestines;L Cells;Link;Lung;Measures;Mediating;Mediator;Metabolic;Metabolic syndrome;Metabolism;microbiome;obesity development;OGTT;Organ;Oropharyngeal;Participant;Persons;Pharmaceutical Preparations;Pharmacy facility;Pilot Projects;Play;Potassium;Protocols documentation;Randomized;rat Gnat3 protein;receptor;Receptor Activation;Research Design;response;Role;Saliva;soft drink;Structure of beta Cell of islet;Sucrose;sugar;sweet taste perception;Sweetening Agents;Taste Buds;Taste Perception;Taste preferences;Testing;Tissues;Tongue;trend;United States National Institutes of Health;Up-Regulation;Water;Weight;Weight Gain

PROJECT_TITLE: Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Chronic Liver Disease and Cirrhosis;Chronic Pain;Clinical Research;Depression;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Liver Disease;Mental Health;Mental Illness;Neurosciences;Pain Research;Schizophrenia;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Substance Misuse;Tobacco;Women's Health Research

PI_NAMEs: GOLDMAN, DAVID  (contact)

PROJECT_TERMS: Acceleration;Accounting;addiction;African American;Aggressive behavior;Aging;Alcohol dependence;alcohol exposure;alcohol response;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholic Hepatitis;Alcohols;Alleles;American Indian Women;Animal Model;Animals;Anterior;anti social;Antipsychotic Agents;Anxiety;Articulation;Autopsy;Behavior;Behavioral;Behavioral Genetics;Brain;Brain imaging;Brain-Derived Neurotrophic Factor;Cell model;Cells;Child;chronic pain;Cirrhosis;Clinical;clinical phenotype;Cocaine;Cognition;Cognitive deficits;cognitive function;Collection;comparative genomics;Corpus striatum structure;Craniocerebral Trauma;craving;Cyclic AMP;decrease resilience;Development;Diagnosis;Diazepam;Disadvantaged;DISC1 gene;Disease;Dopamine;Dopamine D2 Receptor;Dorsal;dosage;DRD2 gene;Drosophila genus;Drug usage;Electroencephalography;Embryo;Emotional;Emotions;Endocrine;Epigenetic Process;Epilepsy;Episodic memory;exome;exome sequencing;externalizing behavior;Family;fatty acid amide hydrolase;Fetal alcohol effects;Founder Generation;functional genomics;gamma-Aminobutyric Acid;Gene Cluster;gene discovery;gene environment interaction;gene network;Genes;Genetic;genetic architecture;Genetic Polymorphism;Genetic study;Genetic Variation;genome wide association study;genome-wide;Genotype;Glutamates;Goals;Growth;GTP Cyclohydrolase;Haplotypes;Hepatocyte;Heritability;high throughput technology;HTR2A gene;Human;imaging genetics;Impulsive Behavior;induced pluripotent stem cell;Inherited;International;Investigation;Knock-out;Knockout Mice;Knowledge;Link;Liver diseases;Locomotion;lymphoblastoid cell line;Maps;Massive Parallel Sequencing;Measures;Medicine;Mental Depression;Mental disorders;Metabolic;metabotropic glutamate receptor 2;Methaqualone;Methods;methylome;Minisatellite Repeats;model organism;Modeling;Molecular;Mus;Naltrexone;National Institute on Alcohol Abuse and Alcoholism;Natural History;Nature;Neurobiology;Neuroglia;neuroimaging;neuroinflammation;neuropeptide Y;Neurosciences;Nicotine;Nicotine Dependence;Nicotine Use Disorder;novel;opioid use disorder;Outcome;Ovarian;Pain;Pathway interactions;Patients;pediatric trauma;Perimenopause;Persons;Pharmaceutical Preparations;Phenotype;Physiological;Placebo Effect;Population;Populations at Risk;Poverty;predictive modeling;preference;Prefrontal Cortex;premenstrual dysphoric disorder;promoter;prospective;Proteins;Rattus;response;Risk;Risk Factors;risk variant;RNA;Role;Sampling;Schizophrenia;schizophrenia risk;Science;serotonin transporter;Sexual abuse;Source;Steroids;Stress;Structure;Study models;Substance Use Disorder;suicidal;Technology;Terminator Codon;Testosterone;theories;trait;transcriptomics;Translational Research;transmission process;treatment response;Variant;Wistar Rats;Withdrawal;Woman

PROJECT_TITLE: Integrative genetics of behavior with high throughput technologies


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Complementary and Integrative Health;Dementia;Dietary Supplements;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_NAME: NATIONAL INSTITUTE ON AGING

PI_NAMEs: DE CABO, RAFAEL  (contact)

PROJECT_TERMS: abeta deposition;Adherence;Adopted;Adult;Age-associated memory impairment;aged;Aging;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid deposition;Amyloid Proteins;Animals;Atrophic;Attenuated;Behavior;Biological Markers;Body Weight;Brain Pathology;brain tissue;Carbohydrates;Cells;Cellular Stress;Cerebrospinal Fluid;Clinical;Clinical Trials;Cognition;Cognitive;cohort;Consumption;Cytoprotection;Dairying;Data;design;Development;Diet;dietary adherence;Dietary Fiber;Dietary Intervention;Disease;Disease Marker;Disease Outcome;Elderly;Electrons;Environment;Epigenetic Process;Fabaceae;Failure;Fatty acid glycerol esters;Flavin Mononucleotide;Flavin-Adenine Dinucleotide;Fruit;fruits and vegetables;Genes;genetic manipulation;Glucose;Goals;good diet;gut microbiome;Health;Health Personnel;healthy aging;Histologic;Human Amyloid Precursor Protein;Impaired cognition;Individual;Inflammaging;Inflammation;Inflammatory;Language;learning ability;lifestyle factors;lipidomics;Magnetic Resonance Imaging;man;Manuscripts;Mediating;Mediterranean Diet;Memory;Metabolic;metabolomics;Methodology;middle age;Molecular;Molecular Target;mouse model;Mus;mutant;Mutation;NADP;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurology;neuron loss;novel;novel strategies;nutrition;Nutritional;Nuts;Observational Study;Older Population;Outcome;overexpression;Oxidoreductase;Pathway interactions;phase 1 study;Phenotype;Physiological;Plant Components;Population;presenilin-1;prevent;Prevention;Preventive;Processed Meats;Prospective, cohort study;protein expression;Quinones;Regimen;Research;Research Personnel;Riboflavin;Role;Senile Plaques;Serum;Source;tau Proteins;Testing;Thinking;Time;tool;treatment strategy;Vegetables;Weaning;western diet;Woman;World Health Organization

PROJECT_TITLE: Cross-Translational nutritional interventions for Alzheimer's Disease: from man to mouse


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Diabetes;Genetics;Microbiome;Nutrition;Obesity;Physical Activity;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: MATTISON, JULIE  (contact)

PROJECT_TERMS: Age;age related decline;Aging;aging biomarker;AMD3100;Anesthesia procedures;Attenuated;Binding;Biological;Biological Assay;biomarker development;Blood;Blood Component Removal;Bone Marrow;Bone marrow biopsy;Cardiovascular Diseases;cardiovascular risk factor;Cell membrane;Cell Volumes;Cells;Central Nervous System;Clinical;Clinical Treatment;Collection;Complex;Complication;CXCR4 gene;Development;diabetes management;Diabetes Mellitus;Diagnostic;Disease;Drug Compounding;Ensure;Environmental Risk Factor;Enzymes;Epigenetic Process;epigenetic regulation;Exercise;FDA approved;Genetic;Genetic Predisposition to Disease;Goals;Granulocyte Colony-Stimulating Factor;gut microbiome;Harvest;Health Status;Hematopoietic Stem Cell Mobilization;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hormones;Human;Immune response;improved;Incidence;Individual;Inflammatory;Inflammatory Response;Intervention;Intervention Studies;Intervention Trial;Learning;life span;Life Style;Liver diseases;Macaca mulatta;Malignant Neoplasms;Marketing;Mediating;Medicine;Memory;Metabolic dysfunction;Metabolism;migration;Monkeys;multiple omics;Muscle;Muscle function;Muscle Proteins;muscle strength;Non-Insulin-Dependent Diabetes Mellitus;nonhuman primate;novel;novel therapeutics;Obesity;obesity treatment;Outcome Measure;Pathogenesis;Pathway interactions;peripheral blood;Pharmaceutical Preparations;Physical activity;Physiological;Population;Post-Translational Protein Processing;Prediabetes syndrome;preservation;Procedures;Process;programs;Protein Biosynthesis;Proteins;Protocols documentation;rapid growth;receptor;Recovery;Research;Resources;Rhesus;Risk Factors;RNA;RNA Splicing;Role;Running;sedentary;side effect;small molecule;Testing;Therapeutic;therapeutic target;Time;Tissues;Training;treadmill;Vascular blood supply

PROJECT_TITLE: Aging Intervention Studies


NIH_SPENDING_CATS: Aging;Complementary and Integrative Health;Dietary Supplements;Genetics;Nutrition;Prevention

PROJECT_TERMS: Adherence;age-related disease;Aging;aging mechanism;Animals;Antioxidants;attenuation;Binding;Bioenergetics;Biological;biological adaptation to stress;Caenorhabditis elegans;Caloric Restriction;carcinogenesis;Carcinogens;Cell membrane;Cell Nucleus;Characteristics;Chemical Agents;Chemopreventive Agent;Coupled;Curcumin;Cytoplasm;Cytoprotection;Development;Diet;Dietary Intervention;dietary restriction;Drosophila genus;Drug Metabolic Detoxication;Electron Transport;Energy Intake;Environment;environmental agent;Enzymes;Equilibrium;Exposure to;extend lifespan;Fasting;feeding;Formulation;functional decline;Genes;Genetic Transcription;Gerontology;Glutathione S-Transferase;Goals;Health;heme oxygenase-1;Human;improved;Insulin;insulin sensitivity;Insulin-Like Growth Factor I;Investments;Knock-out;Knockout Mice;Laboratories;Laboratory Rat;life span;Longevity;Malignant Neoplasms;Mammals;Metformin;mimetics;Mitochondria;Molecular;Mouse Strains;Mus;mutant;Mutation;Neurons;NF-E2-related factor 2;Nuclear;Oxidation-Reduction;Oxidative Stress;Oxidoreductase;Pathway interactions;pharmacologic;Phenotype;Phosphorylation;Physiological;Phytochemical;Prevention strategy;Production;Publishing;Quercetin;Quinones;Regulation;response;Response Elements;Resveratrol;Role;sex;Signal Transduction;Sirtuins;Stress;stress reduction;System;Tissues;transcription factor;Transplantation;tumor

PROJECT_TITLE: NRF2 interactions with SIRT1 and its role on caloric restriction


PROJECT_TERMS: 3' Untranslated Regions;3T3-L1 Cells;Acetylation;adduct;adipocyte differentiation;Adipocytes;age related decline;aged;Aging;animal facility;Animal Model;Animals;Antioxidants;Binding;Binding Proteins;Bioenergetics;Biological;Biological Assay;Biological Models;blood glucose regulation;Body Composition;Caloric Restriction;Cell membrane;Cell model;Cells;Chromatin Structure;Chronic;Chronic Obstructive Pulmonary Disease;Chronology;Code;cofactor;Collaborations;combat;cytochrome b5 reductase;Data;Deacetylase;Deacetylation;design;Diabetes Mellitus;Diet;diet-induced obesity;Dietary Intervention;Disease;DNA Repair;Electron Transport;Energy Metabolism;Enzymes;Equilibrium;Ethanol;extend lifespan;Family;Family member;Fatty acid glycerol esters;Fatty Acids;Gene Transfer Techniques;Generations;Genetic;Genetic Transcription;Genus Hippocampus;glucose metabolism;Health;HepG2;High Fat Diet;Histologic;Histones;Homologous Gene;Human;Immunoprecipitation;improved;Inflammation;Inflammatory;insight;insulin regulation;Insulin Resistance;insulin sensitivity;Intervention;Knock-out;knockout animal;Laboratories;life span;Link;lipid biosynthesis;lipid metabolism;Lipid Peroxidation;Lipids;Liver Cirrhosis;Longevity;Maintenance;Mammals;Mediating;Mediator;member;Membrane;Messenger RNA;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic syndrome;Metabolism;Microarray Analysis;mimetics;Mitochondria;mitochondrial membrane;Modeling;mouse model;Mus;NADH;non-histone protein;novel;NQO1 gene;Nutrient;Nutritional;Obesity;Obesity associated disease;obesogenic;Outcome;overexpression;Oxidation-Reduction;Oxidative Stress;Oxidoreductase;Pathway interactions;pharmacologic;Phospholipids;Physiological;Physiology;preservation;prevent;Prevention;Primary carcinoma of the liver cells;Production;protein degradation;protein expression;protein function;pyridine nucleotide;Quinones;Rattus;Regulation;Reporting;Resistance;respiratory;response;Ribonucleoproteins;RNA-Binding Proteins;Role;Saccharomyces cerevisiae;Serine Proteinase Inhibitors;Signal Transduction;SIRT1 gene;Sirtuins;Small Interfering RNA;Stress;System;Tissues;tool;Transgenic Mice;Transgenic Organisms;Translations;Trypsin;Ubiquinone;Up-Regulation;Work;Yeasts

PROJECT_TITLE: Aging and CR effects on the Plasma Membrane Redox System


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Complementary and Integrative Health;Diabetes;Dietary Supplements;Digestive Diseases;Liver Disease;Natural Products;Nutrition;Obesity;Physical Activity;Prevention

PROJECT_TERMS: 1 year old;5'-AMP-activated protein kinase;Address;Adipocytes;Adipose tissue;Affect;Age of Onset;age related;age related decline;Age related pathologies;age-related disease;Aging;aging mechanism;aging process;Agreement;Albuminuria;Animal Feed;Animals;Antioxidants;Aorta;Apoptosis;Behavior Therapy;Behavioral;Body Weight;Bone Density;bone preservation;Caloric Restriction;Calories;Cardiovascular Diseases;Cardiovascular Physiology;Cataract;Cholesterol;Chronic;Clinic;Cognition;comorbidity;comparison control;comparison intervention;Consensus;Coupled;Data;Diet;diet-induced obesity;Dietary Intervention;Disulfiram;Dose;Elasticity;Elderly;Endocrinology;Energy Intake;Energy Metabolism;epidemiologic data;Evaluation;Exercise;extend lifespan;Fatty acid glycerol esters;Fatty Liver;feeding;Female;functional decline;functional improvement;Gender;Gene Expression Profile;genetic manipulation;Genetic Transcription;Gerontology;glucose metabolism;Goals;Health;Health Benefit;healthspan;healthy aging;Human;Hypertrophy;improved;in vivo;Incidence;Inflammation;Inflammatory;Insulin;Insulin Resistance;insulin sensitivity;interest;Intervention;intervention program;Islets of Langerhans;Laboratories;Laboratory Animals;late life;Life;life span;lipid metabolism;Literature;Liver;Longevity;Longitudinal Studies;Low-Density Lipoproteins;Lower Organism;Macaca mulatta;male;Malnutrition;Manuscripts;Metabolic;Metabolic dysfunction;Metabolism;Metformin;middle age;mimetics;Mitochondria;Modeling;Molecular;Monkeys;Morbidity - disease rate;mortality;Motor;mouse model;Mus;NF-kappa B;nicotinamide-beta-riboside;Non obese;Non-Insulin-Dependent Diabetes Mellitus;nonhuman primate;Nutritional;Obesity;obesogenic;old mice;Oral;Outcome;oxidative damage;Pharmaceutical Preparations;pharmacologic;Phenotype;Physical Performance;Physiological;Physiology;preclinical study;prevent;Process;programs;Publishing;rate of aging;Rattus;Recommendation;Regulation;Research;research clinical testing;response;Resveratrol;Rodent;Role;Scientist;Serum;sex;SIRT1 gene;small molecule;sugar;Supplementation;Testing;Tissues;translation to humans;translational model;Vascular Endothelium;Visceral;Weight Gain

PROJECT_TITLE: Aging Intervention Program


PROJECT_TERMS: 2 year old;4T1;Affect;age effect;Age of Onset;age related decline;age-related disease;Aging;aging mechanism;aging process;Animals;anti-cancer;Behavioral;Biochemical;Blood Glucose;Board Certification;C57BL/6 Mouse;Caloric Restriction;Calories;Cessation of life;Chronic;Chronic Disease;Cognition;cohort;Collection;Complex;Consumption;Coupled;Data;design;Diet;diet-induced obesity;dietary;Dietary Intervention;dietary restriction;Eating;Energy consumption;energy density;Energy Intake;Euthanasia;Experimental Designs;experimental study;extend lifespan;Fasting;Fatty acid glycerol esters;Fatty Liver;feeding;Feeding Patterns;Female;flexibility;Food;Food deprivation (experimental);Frequencies;functional decline;Gene Expression;Generations;Genetic;Gerontology;Glycine;Goals;Health;health assessment;healthspan;healthy aging;Heritability;Histopathology;Hour;Human;Immune;improved;Incidence;insight;Intake;Intermittent fasting;Intervention;Laboratories;Laboratory mice;Laboratory Study;Lead;Life;life span;Liver;Longevity;Lung;Macronutrients Nutrition;Maintenance;male;Malignant Neoplasms;Malnutrition;Measurement;Mediating;Memory;Metabolic;Metabolism;metabolomics;middle age;Modeling;Molecular;Monkeys;Morbidity - disease rate;mortality;Mouse Strains;multiple omics;Mus;Myeloid-derived suppressor cells;Natural Source;nonhuman primate;Nutrient;nutrition;obesogenic;offspring;Outcome;Paper;Pathologist;Pathology;Pathway interactions;Pattern;Periodicity;Phenotype;phrases;Physical Performance;Physiological;Pilot Projects;Plants;preservation;Primary Neoplasm;Property;Protocols documentation;Regimen;Reporting;response;Role;Scientist;Serine;Serum;Severities;sex;Site;Testing;Thinness;Threonine;Time;Time-restricted feeding;Tissue Banks;Tissues;transcriptomics;triple-negative invasive breast carcinoma;tumor growth;Universities;Weight Gain;Wisconsin;Work

PROJECT_TITLE: Calorie restriction and aging


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Neurosciences;Nutrition

PROJECT_TERMS: Age;Age of Onset;age related changes;age-related disease;Aging;aging biomarker;aging process;Animals;Attenuated;Behavior;Body Composition;Brain;burden of illness;Caloric Restriction;Cardiovascular Physiology;Cells;comparison control;Diet;Disease;DNA;Energy Intake;Energy Metabolism;extend lifespan;Fasting;functional decline;Goals;Health;healthspan;Human;immune function;improved;Incidence;Inflammation;Intervention;Learning;life span;Longitudinal Studies;Macaca mulatta;Macular degeneration;Mammals;Memory;Metabolic;Microglia;Mitochondrial DNA;Monitor;Monkeys;Morphology;Myelin;myelination;nonhuman primate;Oligodendroglia;Outcome;oxidative DNA damage;Primates;programs;Publishing;Reporting;reproductive function;Research;Research Design;Serum;Stress;survival outcome;Testing;Time;Tissue Sample;Tissues;Universities;Wisconsin

PROJECT_TITLE: Primate Aging Studies


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: BOUHRARA, MUSTAPHA  (contact)

PROJECT_TERMS: Acceleration;Accounting;accurate diagnosis;Affect;Age;age related;age related changes;age-related disease;Aging;Agreement;Alcohol consumption;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Analysis of Covariance;Anisotropy;Anterior;Apolipoprotein E;Architecture;Attention;Axon;Behavior;Biological;Biological Markers;Biological Models;Biological Process;Biology;Biomedical Research;Biophysics;Blood Vessels;Brain;Brain region;Cell membrane;cerebral atrophy;Cerebrum;Characteristics;Clinical;Clinical Trials;Cognitive;Cognitive deficits;Complex;Curiosities;Data;Data Set;Dementia;Demyelinations;density;Deposition;design;Deterioration;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Early Diagnosis;Early Intervention;Exhibits;Failure;Fiber;Gaussian model;Genetic;Goals;gray matter;Human;Hypertension;Image;imaging biomarker;Impaired cognition;improved;indexing;Individual;interest;Intervention;Link;Liquid substance;longitudinal analysis;Longitudinal Studies;Magnetic Resonance Imaging;Mathematics;Measurement;Measures;Metabolic;Methodology;Methods;Microscopic;mild cognitive impairment;Mission;Modeling;modifiable risk;Molecular;Nerve Degeneration;Neurites;Neurofibrillary Tangles;neuroimaging;neuroimaging marker;neuron loss;neuropathology;non-Gaussian model;normal aging;Obesity;Organelles;Outcome;Paper;Participant;Pathologic;Pathology;Phase;Physical activity;prevent;Prevention;Probability;Process;protein aggregation;Protocols documentation;Radial;rate of change;Regression Analysis;Reporting;Research Design;Research Personnel;Research Project Grants;Risk Factors;Role;Seminal;Senile Plaques;Sensitivity and Specificity;Severities;Smoking;specific biomarkers;Specificity;Structure;Synapses;tau aggregation;tau Proteins;Techniques;Technology;Time;Tissue Model;Tissues;Ventricular;Water;white matter;Work

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: The mean apparent propagator (MAP) MRI indices as neuroimaging biomarkers of cerebral aging, mild cognitive impairment, Alzheimers disease, and associated risk factors


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: GREIG, NIGEL H. (contact)

PROJECT_TERMS: 3xTg-AD mouse;Academia;Acceleration;Adult;Adverse effects;Affect;Age;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease therapeutic;Amino Acids;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;analog;Animal Disease Models;Animal Model;Animals;Anti-Inflammatory Agents;Antioxidants;Apolipoprotein E;Basic Science;Behavioral;behavioral impairment;Biological;Blood Vessels;Brain;Cell Death;Cells;Central Nervous System;cerebral atrophy;Cerebrovascular system;Chemistry;Chronic;Clinic;Clinical;Clinical assessments;clinical development;Clinical Drug Development;Clinical Research;Clinical Trials;Cognitive deficits;Collaborations;Complex;course development;cytokine;cytokine release syndrome;Degenerative Disorder;Dementia;Deposition;design;Detection;Development;Disease;Disease Progression;DNA Damage;Dose;drug candidate;drug development;Drug Targeting;drug-like compound;early phase clinical trial;Elderly;Elements;Embryo;entorhinal cortex;Event;Excision;Extramural Activities;Failure;familial Alzheimer disease;Fostering;Generations;Genes;glial activation;Goals;Growth;hallmarks of aging;Health Benefit;Human;Image Analysis;Immunomodulators;Impairment;in utero;in vivo;Industry;Inflammation;Inflammatory;inhibitor;Interruption;Intervention;Intramural Research Program;Investigation;Investigational Therapies;Legal patent;Libraries;Licensing;Lipid Peroxidation;Lymphocytic Infiltrate;Maintenance;MAPT gene;Mediating;Messenger RNA;Microglia;Mitochondria;Modeling;Modification;Molecular Target;mouse model;multidisciplinary;Mus;Mutation;Nature;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;Neurology;neuron apoptosis;neuron loss;Neuronal Dysfunction;Neurons;neuropathology;neurotoxic;normal aging;novel;novel therapeutics;Oxidative Stress;Pathology;Peripheral Nervous System Diseases;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;phenserine;pomalidomide;Population;Positioning Attribute;Positron-Emission Tomography;posttranscriptional;pre-clinical;preclinical study;presenilin;Production;protein aggregation;protein oligomer;Protein Precursors;Proteins;proteostasis loss;Psychiatry;Reactive Oxygen Species;Reporting;Research;Research Project Grants;resilience;Resources;response;Rewards;Rodent;Role;Sedation procedure;Serum;small molecule;Structure;Symptoms;tau Proteins;Teratogens;Testing;Thalidomide;therapeutic candidate;Therapeutic Intervention;Time;TNF gene;Toxic effect;Translating;Translations;United States National Institutes of Health;Variant;Vertebral column

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: Alzheimer's disease drug development


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Diabetes;Neurodegenerative;Neurosciences;Nutrition

PROJECT_TERMS: Age;age related;age related changes;Aging;Alzheimer's Disease;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein Precursor;Apoptosis;Appearance;Area;Baltimore;Blood;Blood Glucose;Blood Vessels;Body Weight;Brain;brain metabolism;Caloric Restriction;Cell Physiology;Cell Proliferation;Cells;central nervous system vasculature;cerebral atrophy;Chemical Engineering;Chinese;Cholinesterases;Clinical Course of Disease;Clinical Trials;Cognitive;Cognitive Dissonance;cognitive function;cognitive performance;comorbidity;copolymer;cost;cytotoxic;cytotoxicity;Dementia;Deposition;Developed Countries;Diabetes Mellitus;diabetic;Disabling;Disease;Disease Progression;Drug Targeting;Eating;Economic Burden;Endoplasmic Reticulum;Epidemic;Epidemiology;epidemiology study;experimental study;flexibility;Functional disorder;Gastric Emptying;Generations;Glucose;glucose metabolism;Glutamate Receptor;Goals;Health;Heart;Hippocampus;Human;human subject;Hyperglycemia;Hypertension;Impaired cognition;Impairment;improved;In Vitro;in vivo;Incidence;Induction of Apoptosis;Inflammation;Insulin;Insulin Resistance;insulin secretion;Insulin-Dependent Diabetes Mellitus;Intervention;islet amyloid polypeptide;Islet Cell;Islets of Langerhans;Journals;Kidney;Link;Longitudinal Studies;Membrane;Metabolic;Metabolic Diseases;mimetics;Mitochondria;Molecular;Nerve Degeneration;Neurocognitive Deficit;Neurodegenerative Disorders;neurofibrillary tangle formation;neuron loss;neuropathology;Neuropharmacology;Non-Insulin-Dependent Diabetes Mellitus;nonhuman primate;Organ;Pancreas;Pancreatic Hormones;Participant;Pathogenesis;Pathologic;Pathologic Processes;Pathway interactions;Patients;Peptides;Persons;Play;Pramlintide;Prevalence;Prospective Studies;protein aggregation;Proteolysis;proteostasis;Psyche structure;Reactive Oxygen Species;Regulation;Research;Research Project Grants;Role;Satiation;social;Symptoms;Synapses;synergism;tau Proteins;Testing;Therapeutic;treatment strategy;Update;Weight

PROJECT_TITLE: ALZHEIMERS RESEARCH PROJECT: Amyloidogenic Amylin: Linking Type 2 Diabetes and Alzheimers Disease in Humans and Non-Humans Primates.


ADMINISTERING_IC: CL

IC_NAME: CLINICAL CENTER

ORG_NAME: CLINICAL CENTER

PI_NAMEs: EGGERMAN, THOMAS  (contact)

PROJECT_TERMS: 2019-nCoV;Acute Lung Injury;age related;antagonist;Antigen Presentation;Apolipoprotein A-I;Apolipoproteins B;Apoptotic;Bacterial Model;Blood Vessels;BODIPY;Brain Injuries;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;CD36 gene;Cell Count;Cell Line;Cells;Chronic Lung Injury;Collaborations;Coronary Arteriosclerosis;coronary plaque;cytokine;Disease;emerging virus;endothelial dysfunction;Endotoxins;Excision;Extravasation;Hepatitis C;high risk;Host Defense;Hour;Human;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;Injections;Injury to Kidney;Knock-out;Lipopolysaccharides;Lipoprotein Receptor;Low Density Lipoprotein Receptor;Lung;Lung infections;lung injury;Mediating;microbial;Molecular;Mus;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;neural;Neutrophil Infiltration;overexpression;pathogen;pathogenic virus;Pattern;Pattern recognition receptor;Peptides;Peripheral;Phagocytosis;Phospholipids;Play;Production;Protein Family;Proteins;Publishing;Pulmonary Inflammation;receptor;Resolution;RNA Splicing;Role;SARS-CoV-2 pathogenesis;SARS-CoV-2 spike protein;scavenger receptor;Sepsis;Septic Shock;SR-B proteins;Structure of parenchyma of lung;System;therapeutic candidate;Tissues;Toll-like receptors;Transgenic Mice;Transgenic Organisms;uptake;Variant;vascular endothelial dysfunction;Viral;Virus;Virus Diseases;Wild Type Mouse

PROJECT_TITLE: The Role of the Scavenger Receptor B Family Proteins (SR-BI, SR-BII and CD36) in Infection and Sepsis


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Disability Research;Epilepsy;Eye Disease and Disorders of Vision;Genetics;Hearing Loss;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Usher Syndrome

PI_NAMEs: FRIEDMAN, THOMAS  (contact)

PROJECT_TERMS: Active Sites;Alleles;Alternative Splicing;Amino Acids;Apical;Atomic Force Microscopy;Audiology;Auditory;Auditory system;Basic Science;Biochemistry;Blindness;Brain;causal variant;Cells;Cellular biology;childhood hearing loss;Clinical;clinical center;Clinical Data;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complement;Conceptions;conditional knockout;consanguineous family;CRISPR/Cas technology;deaf;Deafblind;deafness;design;Development;Disease;Doctor of Philosophy;DOOR (deafness-onychodystrophy-osteodystrophy-retardation) syndrome;Dystonia;Embryo;Engineering;Enrollment;Epitopes;Exclusion;Exercise;exome sequencing;Exons;F-Actin;Family;Family Study;Female;Functional disorder;gene function;gene therapy;Genes;Genetic;genetic variant;Genetic Variation;Genomic DNA;Genotype;Goals;Hair Cells;Hearing;hearing impairment;Hearing Tests;Human;human disease;Human Genome;human model;human subject;Inherited;inner ear diseases;Institutional Review Boards;interest;Laboratories;Labyrinth;Link;male;male fertility;Maps;Measures;Medical;Medical Genetics;member;Mentors;Michigan;Missense Mutation;Molecular;Molecular Biology;Molecular Genetics;mouse genetics;mouse model;Mus;Mutant Strains Mice;Mutate;Mutation;National Institute on Deafness and Other Communication Disorders;Natural History;normal hearing;Pakistan;Pathogenicity;Pathway interactions;Phenotype;Phosphoric Monoester Hydrolases;Physicians;Protein Isoforms;protein protein interaction;Proteins;Protocols documentation;Puerto Rico;Quinones;recessive genetic trait;Reporting;Research Personnel;Research Project Grants;RNA Splicing;Rolandic Epilepsy;Science;segregation;Seizures;Site;skills;small molecule;SNP array;sperm cell;Splice-Site Mutation;Sterility;structural biology;Supporting Cell;Syndrome;tool;Transcript;United States National Institutes of Health;Universities;Usher Syndrome;Variant;vestibular system;Visual;Zein

PROJECT_TITLE: Identification of Genes Causing Syndromic and Nonsyndromic Hearing Impairment


ORG_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

PROJECT_TERMS: Actins;ADAMTS;Adult;age related;Apical;Auditory system;autosome;base;Birds;Brain;Bundling;Cell Physiology;Cells;Collaborations;Communication;Cooperative Research and Development Agreement;deaf;deafness;Detection;Development;Epitopes;Exons;Extramural Activities;Failure;Family;Force of Gravity;gene function;Genes;Genetic;genetic analysis;genetic variant;Goals;Hair;Hair Cells;Head Movements;Hearing;hearing impairment;Human;human model;Image;in vivo;Inner Hair Cells;Knockout Mice;Laboratories;Labyrinth;LoxP-flanked allele;Maintenance;Manuscripts;MAP3K1 gene;Michigan;Molecular Genetics;mouse genome;mouse model;Mus;Mutant Strains Mice;Mutation;Nature;Organ;Organ of Corti;PCDH15 gene;Pharmacologic Substance;Phenotype;protein function;Protein Isoforms;Proteins;Protocols documentation;Publishing;recruit;Reporting;response;RNA Splicing;Role;segregation;Seizures;single molecule;small molecule;sound;superresolution microscopy;Supporting Cell;Surface;Transcript;United States;United States National Institutes of Health;Universities;Variant;vestibular system;Work

PROJECT_TITLE: Functional Studies of "Deafness Genes" Essential for Hearing


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: NATIONAL EYE INSTITUTE

PI_NAMEs: BHARTI, KAPIL  (contact)

PROJECT_TERMS: Affect;Age related macular degeneration;Aging;Atrophic;Blindness;cell age;Cell Culture Techniques;Cell Death;Cell Membrane Permeability;Cellular Stress;Choroid;Complement;Defect;Deposition;Development;differentiation protocol;Disease;Elderly;electrical measurement;Epithelium;Exhibits;Fibroblasts;Functional disorder;Genetic;geographic atrophy;Goals;Homeostasis;Human;In Vitro;induced pluripotent stem cell;lipid metabolism;lipidomics;Mendelian disorder;Modeling;monolayer;Pathogenesis;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Photoreceptors;pluripotency;Population;postmitotic;Process;protein aggregation;Publishing;Resistance;Retinal Degeneration;Retinal Diseases;risk variant;Role;Serum;Signal Pathway;skin biopsy;Stargardt's disease;Stress;Structure of retinal pigment epithelium;Therapeutic Intervention;Tissues;tool

PROJECT_TITLE: Developing an "aging" model using iPSC-derived RPE cells


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Adult;Affect;Animal Model;Antibodies;Aphidicolin;Apical;Biotechnology;Cell Cycle;Cell Therapy;Cell Transplantation;cell type;Cells;Cilia;ciliopathy;cilium biogenesis;Collaborations;Defect;Degenerative Disorder;Development;Dinoprostone;disease model;Dynein ATPase;Electrophysiology (science);Epithelium;Eye diseases;fetal;Gene Expression Profile;Gene Expression Profiling;Goals;high throughput screening;human induced pluripotent stem cells;improved;In Vitro;induced pluripotent stem cell;inhibitor;insight;Label;machine learning algorithm;macula;Mediating;Mediator;member;Methods;monolayer;mouse model;Mus;Mutant Strains Mice;Onset of illness;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;Phenotype;Photoreceptors;postnatal;pre-clinical;Process;protein transport;Protocols documentation;Sampling;Shapes;Therapeutic;Tissues;WNT Signaling Pathway;Work

PROJECT_TITLE: Developing functional and authenticated RPE tissue from iPS cells


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Human Fetal Tissue;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

PROJECT_TERMS: Acute;Air;Animal Model;Animals;Autologous;Biotechnology;Bulla;Cell Differentiation process;Cell Line;Cell Therapy;cell type;Chronic;Clinical;clinical center;clinical efficacy;Clinical Protocols;Coculture Techniques;Collaborations;Eye;Family suidae;FDA approved;Goals;Histologic;Human;human subject;Immunocompromised Host;induced pluripotent stem cell;Institutional Review Boards;Liquid substance;Nonexudative age-related macular degeneration;Operative Surgical Procedures;Organ;participant enrollment;Patients;Phase;Phase I Clinical Trials;phase I/IIa trial;Photoreceptors;pre-clinical;preclinical efficacy;preclinical safety;Procedures;Process;Retina;Safety;safety assessment;Saline;Sampling;scaffold;stem cells;Technology Transfer;Teratoma;Testing;Therapeutic;Time;Transplantation;tumor;United States National Institutes of Health;Vitrectomy;Work

PROJECT_TITLE: Developing autologous iPSC-RPE based IND for AMD patients


NIH_SPENDING_CATS: Aging;Bioengineering;Eye Disease and Disorders of Vision;Human Fetal Tissue;Macular Degeneration;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: 3-Dimensional;Age related macular degeneration;Anatomy;Back;biodegradable scaffold;bioprinting;Blindness;Blood capillaries;Blood Vessels;Blood-Retinal Barrier;Cell Death;Cessation of life;Choroid;Collagen;Complex;Development;Disease;Dryness;Elderly;Encapsulated;Endothelial Cells;Event;Eye;Fibroblasts;Gel;Goals;human model;In Vitro;in vitro Model;induced pluripotent stem cell;induced pluripotent stem cell technology;Macrophage;Modeling;monolayer;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pericytes;Pharmaceutical Preparations;Photoreceptors;Process;Proliferating;Property;Publishing;response;Retinal Degeneration;Role;scaffold;Side;Structure of retinal pigment epithelium;Testing;Therapeutic;Thinness;Tissue Engineering;Tissues;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Developing 3D patient-specific iPS cell derived RPE/choroid models


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease;Mucopolysaccharidoses (MPS);Orphan Drug;Pediatric;Rare Diseases

ORG_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

PI_NAMEs: PUERTOLLANO-MORO, ROSA  (contact)

PROJECT_TERMS: Acids;Address;adeno-associated viral vector;Adult;Affect;Animal Disease Models;animal old age;Animals;Antigen Presentation;Arginine;Assessment tool;Atrophic;Autophagocytosis;Birth;Blood Circulation;blood-brain barrier crossing;Bone remodeling;Cardiac;Cardiomyopathies;Cell membrane;Cell Physiology;Cells;cellular pathology;Central Nervous System;Childhood;Cholesterol Homeostasis;Clinic;Clinical;clinical development;Collaborations;Defect;Development;Disease;Disease Progression;Down-Regulation;Effectiveness;effectiveness evaluation;enzyme activity;enzyme replacement therapy;Enzymes;Excision;FDA approved;Financial Hardship;Functional disorder;Future;gallium arsenide;Ganglioside Sialidase Deficiency Disease;gene therapy;Gene Transfer;Glucose;Glycogen;Glycogen storage disease type II;glycosylation;Goals;heart function;Homeostasis;Human;Image;Immune response;improved;Infant;Injections;interest;Intervention;intravital microscopy;knock-down;Knockout Mice;Laboratories;Lysosomal Storage Diseases;Lysosomes;mannose 6 phosphate;Mediating;Metabolic;Metabolic Diseases;Methodology;Miglustat;Molecular;Mus;Muscle;Muscle Fibers;muscle form;Muscular Atrophy;Myocardium;Myopathy;novel;novel therapeutics;Organelles;Organism;Pathogenesis;Pathogenicity;Pathology;Patients;preclinical study;Preclinical Testing;Prevalence;prevent;Proteins;proteostasis;receptor;Recombinants;repaired;Residual state;Resolution;Respiratory Diaphragm;response;restoration;Sampling;Signal Transduction;Site;Skeletal Muscle;standard of care;Stress;Supplementation;Surface;Techniques;Therapeutic;therapeutic enzyme;Therapeutic Intervention;therapeutic target;Tissues;Tongue;trafficking;Translating;uptake;Variant;Visualization;Wasting Syndrome;Work

PROJECT_TITLE: Lysosomal Diseases


NIH_SPENDING_CATS: Genetics;Prevention

PI_NAMEs: LEVINE, RODNEY L. (contact)

PROJECT_TERMS: Affect;Age;Aging;Aminoacyl-tRNA Biosynthesis Pathway;Anabolism;Antioxidants;Back;Bacteria;Biological Models;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium;calmodulin-dependent protein kinase II;Carbon;Cardiac;cell growth regulation;Cell Line;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Cysteine;Disease;disulfide bond;Disulfides;Energy-Generating Resources;Genes;Genetically Engineered Mouse;genome-wide;Guide RNA;Heart;Hepatocyte;Ischemia;Knock-out;Laboratories;Lactate Dehydrogenase;Libraries;Mediating;Metabolic Pathway;Metabolism;metabolomics;Methionine;methionine sulfoxide;methionine sulfoxide reductase;microbiome;Modeling;Modification;Mus;Mutant Strains Mice;Mutate;Mutation;Neurodegenerative Disorders;oxidation;Oxidative Stress;Oxidoreductase;Oxygen Consumption;Paracoccus denitrificans;Pathologic;Pathology;Physiological;Physiology;Post-Translational Protein Processing;prevent;Process;Production;protective pathway;Proteins;Protocols documentation;Quinones;Reactive Oxygen Species;Regulation;repaired;Reperfusion Injury;Reperfusion Therapy;Reporting;Research;Resistance;Respiration;Role;Serine;Signal Transduction;System;Transgenic Mice

PROJECT_TITLE: Oxidative Modification Of Proteins


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD)

PI_NAMEs: PASTOR, RICHARD WALTER (contact)

PROJECT_TERMS: Agreement;algorithm development;anti-microbial peptide;apolipoprotein C-II;Apolipoproteins;Area;Binding;Biopolymers;Carbohydrates;Cell fusion;Cell membrane;Chemistry;Cholesterol;Complement;Complex;Computer Simulation;computer studies;Data;Deuterium;Development;Diffusion;Drug Design;Elasticity;Experimental Models;experimental study;Gangliosides;Glycolipids;Goals;High Density Lipoproteins;improved;insight;interfacial;Ion Channel;Ions;Lateral;Lipids;mechanical force;Membrane;membrane model;Methodology;Methods;mimetics;Modeling;molecular dynamics;molecular mechanics;monolayer;particle;Partition Coefficient;Peptides;Periodicals;Permeability;Pharmaceutical Preparations;Phase;Phase Transition;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Physics;pressure;Process;programs;Proteins;Publishing;Quantum Mechanics;Relaxation;Reporting;Research;Roentgen Rays;Signal Transduction;simulation;stapled peptide;Structure;System;Triglycerides;Unsaturated Fats;Very low density lipoprotein;Viscosity;Water;Work

PROJECT_TITLE: Computer Simulations of Membranes and Biopolymers


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Estrogen;Genetics;Lymphatic Research;Rare Diseases;Women's Health Research

PI_NAMEs: MOSS, JOEL  (contact)

PROJECT_TERMS: Adenocarcinoma;Adenosine Diphosphate Ribose;ADP Ribose Transferases;ADP ribosylation;Adrenal Glands;Affect;Agar;Age Months;Agreement;Alleles;Amino Acids;anastrozole;Animal Model;Annual Reports;apoptosis inducing factor;Appearance;Arginine;Bacterial Toxins;Biochemical Reaction;biological systems;Brain;breast cancer progression;carcinogenesis;Cell Death;Cell Differentiation process;Cell model;Cell Nucleus;Cell Proliferation;Cells;Cervical lymph node group;Cholera Toxin;Circulation;Cytoplasm;Data;Data Analyses;Deacetylation;Development;Diphtheria Toxin;DNA;DNA Repair;Dose;Embryo;Endometrial adenocarcinoma;endonuclease;enzyme activity;Estrogen Antagonists;Estrogen Therapy;Estrogens;Family;Family member;Female;female sex hormone;Fibroblasts;follow-up;Gender;gender disparity;Genes;Genetically Engineered Mouse;Genotype;Glycoside Hydrolases;Gonadal Steroid Hormones;Growth;Hemangiosarcoma;Heterozygote;hormone deficiency;Hormones;Hydrolase;Hydrolysis;Implant;In Vitro;in vivo;Incidence;intravenous injection;Knockout Mice;Laboratories;Loss of Heterozygosity;Lung Adenocarcinoma;Lymphoma;male;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mammalian Cell;member;Mesentery;Metastatic Neoplasm to the Lung;Mono(ADP-Ribose) Transferases;mortality;mouse model;Mus;Mutate;Mutation;Natural regeneration;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Niacinamide;Non-Steroidal Aromatase Inhibitor;Nude Mice;O-Acetyl-ADP-Ribose;Organ;Ovariectomy;Ovary;Oxidative Stress;Pathway interactions;Peptides;pharmacologic;Poly Adenosine Diphosphate Ribose;Poly(ADP-ribose) Polymerases;Post-Translational Protein Processing;Predisposition;preneoplastic cell;Primary carcinoma of the liver cells;Process;Proliferating;Protein Family;protein function;Proteins;Reaction;Regulation;Reporting;Residual state;Role;Serine;Signal Transduction;Sirtuins;Spleen;subcutaneous;Symptoms;Tamoxifen;Testosterone;Toxin;tumor;Tumor Burden;tumor growth;tumor initiation;Tumor Suppressor Proteins;tumorigenesis;Uterus;Wild Type Mouse;Woman;Xenograft Model

PROJECT_TITLE: ADP-ribosylation Cycles


NIH_SPENDING_CATS: Infectious Diseases

PI_NAMEs: TJANDRA, NICO  (contact)

PROJECT_TERMS: 2019-nCoV;Adopted;Anti-viral Agents;Binding;Binding Sites;Biological;Biological Assay;Biological Process;C-terminal;Capsid;Cell membrane;cell motility;Cells;Clinical;Collaborations;Complex;Coronavirus;Cysteine;Degradation Pathway;Dependence;Development;Dimerization;Disease;Environment;Enzyme Activation;Enzymes;Event;Exhibits;experimental study;Family;flexibility;Generations;Goals;Half-Life;High Pressure Liquid Chromatography;HIV-1;imaging probe;improved;inhibitor;Isomerism;Knowledge;Lanthanoid Series Elements;Ligands;Ligase;Link;Lobe;Measures;Metals;Methylation;Molecular;molecular dynamics;Mutation;N-terminal;National Institute of Allergy and Infectious Disease;Nature;new technology;Nitrogen;novel;Nuclear;particle;Pathway interactions;Phase;Physiological;Population;Predisposition;prevent;Process;Production;protein degradation;Protein Dynamics;protein function;protein protein interaction;Proteins;Proton Pump Inhibitors;Protons;recruit;Regulation;Research;Research Project Grants;response;RNA;Scheme;Signal Transduction;Site;small molecule;Specificity;Spin Labels;Stimulus;Structure;System;Technology;Temperature;Testing;trafficking;Tyrosine;UBD protein;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Viral;Viral Proteins;Virion;Virus;virus testing;Virus-like particle;Water

PROJECT_TITLE: Nmr Studies Of The Regulation Of Cell Signaling


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: LEE, JENNIFER  (contact)

PROJECT_TERMS: Address;Adopted;age related;alpha synuclein;Alzheimer's Disease;Amyloid;amyloid formation;amyloid structure;Amyotrophic Lateral Sclerosis;Binding;Biochemical;biophysical analysis;Cellular Stress;Chemicals;Complex;Cryoelectron Microscopy;Cytosol;Dementia with Lewy Bodies;Development;Disease;disease phenotype;DNA-Binding Proteins;Dose;Electron Microscopy;Electrostatics;Encephalopathies;Environment;Etiology;experimental study;Filament;Fluorescence Recovery After Photobleaching;Fluorescence Spectroscopy;Frontotemporal Dementia;Genetic Code;Goals;Growth;Health;human disease;in vivo;insight;interest;Intervention;Investigation;Light;Lipids;Liquid substance;Lysine;Lysosomes;Magnetic Resonance Spectroscopy;Mass Spectrum Analysis;Membrane;Methods;Molecular;Molecular Biology;Molecular Conformation;Multiple System Atrophy;Nature;Neutrons;NMR Spectroscopy;novel;Nuclear;Nuclear Import;optogenetics;Organelles;Parkinson Disease;Pathologic;Photochemistry;Post-Translational Protein Processing;Process;protein aggregation;protein misfolding;protein structure;protein TDP-43;Protein translocation;Proteins;Proteolysis;proteostasis;Reaction;recruit;Research;response;Role;self assembly;Side;Site;Sodium Chloride;Solid;stress granule;Structure;TDP-43 aggregation;Testing;Time;tool;unnatural amino acids;Work

PROJECT_TITLE: Protein Misfolding and Aggregation


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Machine Learning and Artificial Intelligence

PI_NAMEs: NEUMAN, KEIR  (contact)

PROJECT_TERMS: Aging;Antibiotics;Artificial Intelligence;Bacterial Genome;base;Binding;Biochemical;biophysical model;Cell Death Induction;Cell division;chemotherapy;Chromosomal Instability;chromosome replication;Chromosomes;Ciprofloxacin;Clinical;Collaborations;college;Comparative Study;Complement;COVID-19 pandemic;Darkness;Data;Dependence;Development;DNA;DNA Repair;DNA topoisomerase II alpha;DNA Topoisomerase IV;DNA Topoisomerases;Engineering;Enzymes;Equilibrium;Escherichia coli;experimental study;Florida;Fluorescence;Frequencies;Goals;Gold;helicase;Human;improved;In Vitro;in vivo;Incidence;Individual;inhibitor;instrument;instrumentation;interest;International;Link;Location;Machine Learning;Magnetism;Maintenance;Malignant Neoplasms;Maps;Maryland;Measurement;Measures;Mechanics;Modality;Modeling;Molecular;molecular dynamics;molecular scale;Monitor;Motion;Multienzyme Complexes;next generation sequencing;Nucleotides;particle;Pathway interactions;plasmid DNA;Play;Poison;Poisoning;preference;prevent;professor;Proteins;Relaxation;repair enzyme;Research;Resolution;response;RNA-Directed RNA Polymerase;Role;SARS-CoV-2 inhibitor;simulation;single molecule;Single-Stranded DNA;Sister;Site;small molecule inhibitor;Specificity;Structure;Superhelical DNA;Techniques;temporal measurement;Testing;Time;Topoisomerase;Topoisomerase II;Topoisomerase III;Torque;Type I DNA Topoisomerases;Universities;Washington;Work

PROJECT_TITLE: Single-molecule measurements of DNA topology and topoisomerases


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Kidney Disease;Urologic Diseases

PI_NAMEs: KNEPPER, MARK  (contact)

PROJECT_TERMS: Ablation;activating transcription factor 1;Animal Model;Animals;antidiuresis;Apical;aquaporin-2;Area;Argipressin;ATAC-seq;Atlases;AVPR2 gene;Binding;Binding Sites;Bioinformatics;Biological;Biology;Biomedical Engineering;Calmodulin;Catalytic Domain;Cell membrane;Cell model;Cell Signaling Process;cell type;Cells;ChIP-seq;Chromosome Mapping;Cirrhosis;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Communities;Computational Technique;computerized tools;Computing Methodologies;Congestive Heart Failure;Coupled;CREB1 gene;CRISPR screen;CRISPR/Cas technology;Custom;Cyclic AMP-Dependent Protein Kinases;Data;Data Analyses;data resource;Data Set;data sharing networks;Databases;deep sequencing;dilutional hyponatremia;Disease;Distal convoluted renal tubule structure;DNA sequencing;Duct (organ) structure;Ductal Epithelial Cell;Ductal Epithelium;Elements;Enhancers;Epithelial Cells;Epithelium;equilibration disorder;Equilibrium;Evaluation;Excretory function;experimental study;Family;Fluorescence-Activated Cell Sorting;G-Protein-Coupled Receptors;Gene Expression;Genes;Genetic Transcription;genome editing;genome-wide;Genomics;Goals;gram-negative sepsis;Hand;Homeobox;Hypokalemia;Individual;Inflammation;Java;Kidney;Laboratories;Limb structure;Link;Lithium;Maps;Mass Spectrum Analysis;mathematical methods;Mediating;Mediator;member;Messenger RNA;method development;Methods;Modeling;Molecular;Mus;mutant;Mutation;Myosin Light Chain Kinase;National Heart, Lung, and Blood Institute;Nephrons;neurophysins;next generation;novel;Nuclear;Nuclear Translocation;Occupations;Persons;Phosphoproteins;phosphoproteomics;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;Polyuria;Post-Translational Protein Processing;Process;protein activation;Protein Kinase;Proteins;Proteome;Proteomics;Proteomics Shared Resource;Pythons;Regulation;renal epithelium;Renal tubule structure;Research;Resources;response;Role;Signal Transduction;single-cell RNA sequencing;Site;Sodium Chloride;Software Tools;solute;Syndrome;Systems Biology;tandem mass spectrometry;Techniques;Testing;Thick;tool;Toxic effect;trafficking;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;Ureteral obstruction;urinary tract obstruction;V2 Receptors;validation studies;vasopressin resistant diabetes insipidus;Vasopressins;Water;water channel;Work

PROJECT_TITLE: Solute And Water Transport In Renal Epithelia


NIH_SPENDING_CATS: Bioengineering;Biotechnology

PI_NAMEs: KNUTSON, JAY R (contact)

PROJECT_TITLE: Time Resolved Fluorescence Spectroscopy


NIH_SPENDING_CATS: Bioengineering

PI_NAMEs: SELLERS, JAMES  (contact)

PROJECT_TERMS: Actins;Adopted;Affect;Alternative Splicing;Amino Acid Sequence;analog;Area;Baculoviruses;Binding;Biological Assay;Cells;Collaborations;copolymer;Cryoelectron Microscopy;Crystallization;Data;depolymerization;Enzymes;Filament;Fluorescence Resonance Energy Transfer;force sensor;G Actin;Genes;H-Meromyosin;human disease;Image;In Vitro;in vivo;interest;Isometric Exercise;Kinetics;Label;Length;Light;Link;Mammals;Mechanics;Microfilaments;Microscope;monomer;Motility;Motor;Movement;Mutation;Myosin ATPase;Myosin Regulatory Light Chains;Myosin Rod;Myosin S-2;Myosin Type II;non-muscle myosin;Nonmuscle Myosin Type IIA;optic trap;optical traps;paralogous gene;Pattern;Phosphorylation;polymerization;Polymers;Process;Property;Proteins;Publishing;Regulation;Resolution;RNA Splicing;single molecule;Structure;Surface;System;Tail;Time;Total Internal Reflection Fluorescent;Visit

PROJECT_TITLE: Regulation Of Smooth and Nonmuscle Myosin


NIH_SPENDING_CATS: Aging;Cardiovascular;Estrogen;Heart Disease;Women's Health Research

PI_NAMEs: MURPHY, ELIZABETH  (contact)

PROJECT_TERMS: Acute;Address;adeno-associated viral vector;Age;Animal Model;Animals;attenuation;Binding;Bioenergetics;Calcium;calcium indicator;calcium uniporter;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cause of Death;Cell Death;Clinical Trials;Confocal Microscopy;Data;Disease;Enzyme Activation;enzyme activity;Estrogen Nuclear Receptor;Estrogens;Female;Fluorescence;Generations;Genes;Goals;Heart;Heart Diseases;Heat shock proteins;Hormone replacement therapy;Infarction;Injections;Injury;Ischemia;ischemic injury;Knock-out;Location;male;Measures;Mediating;Menopause;Methods;Microscopy;Mitochondria;Mitochondrial Matrix;Mitochondrial Membrane Protein;Modeling;Modification;Monitor;Mus;neonate;Nitric Oxide;Nitric Oxide Synthase;non-genomic;Organ;Pathway interactions;Perfusion;PIK3CG gene;Post-Translational Protein Processing;Postmenopause;Premenopause;Process;Proteins;Publishing;Reperfusion Injury;Reperfusion Therapy;Research;Resolution;response;Selective Estrogen Receptor Modulators;Signal Transduction;Spectrum Analysis;Testing;transmission process;uptake;Viral Vector;Woman;Women's Health;Women's mortality

PROJECT_TITLE: Mechanisms involved in male-female differences in cardioprotection


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

PROJECT_TERMS: Acceleration;Adult;Calcium;Cardiac Myocytes;cardioprotection;Cardiovascular Diseases;Cause of Death;Cell Death;Cell division;Cell membrane;Cellular Structures;Cessation of life;Clinic;cyclophilin D;Electron Transport;Failure;Generations;Goals;Heart;Heart Diseases;heart function;Homeostasis;Infarction;Inner mitochondrial membrane;insight;Ion Pumps;Ions;Ischemia;ischemic injury;Isomerase;Location;Measures;Metabolism;Methods;Mitochondria;mitochondrial permeability transition pore;Modeling;mouse model;mutant;Myocardial Ischemia;novel;Oxidation-Reduction;Oxygen;Perfusion;Permeability;Pharmaceutical Preparations;Plasma Cells;Play;Post-Translational Protein Processing;preconditioning;Proteins;Reactive Oxygen Species;Regulation;Reperfusion Injury;Reperfusion Therapy;Reporting;response;Role;Rupture;Sex Differences;Signal Pathway;Signal Transduction;Testing;Translating

PROJECT_TITLE: Mechanisms of cardiac ischemia-reperfusion injury and cardioprotection


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Immunotherapy;Orphan Drug;Pediatric;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PI_NAMEs: YOUNG, NEAL S (contact)

PROJECT_TERMS: Admission activity;Adverse event;Advocate;Aftercare;Age;Anemia;Animal Model;Antithymoglobulin;Aplastic Anemia;Autologous;B-Lymphocytes;Benzene;Biological Products;Blood Cells;Bone Marrow;Bone Marrow Diseases;bone marrow failure syndrome;Bone Marrow Transplantation;CD8-Positive T-Lymphocytes;Cell-Mediated Cytolysis;Cells;Chemical Exposure;Child;Childhood;chronic T-cell leukemia;Classification;Clinical;clinical center;Clinical Data;Clinical Protocols;Clinical Trials;Clonal Evolution;cohort;Collaborations;college;Constitution;Cyclosporine;cytokine;cytotoxic;Data;Development;Diagnosis;Disease;disease classification;Dose;Drug toxicity;Drug usage;Dysmyelopoietic Syndromes;Early Intervention;effector T cell;Elderly;Epitope spreading;Evolution;Failure;Fanconi's Anemia;Fatty acid glycerol esters;Flow Cytometry;follow-up;Functional disorder;Future;Genetic;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hemorrhage;Hepatitis;high risk;Human;Immune;Immune mediated destruction;Immune response;Immune system;Immune System Diseases;Immunological Models;Immunosuppression;Immunosuppressive Agents;improved;in silico;Induction of Apoptosis;Infection;Infusion procedures;inhibitor;Interferon Type II;International;Intervention;Laboratories;Laboratory Research;large datasets;Ligands;Link;London;Lymphocyte;Machine Learning;Malignant - descriptor;Marrow;Mediating;Medical;member;mimetics;Modeling;Molecular;Morality;mouse model;Mutate;Mutation;Myeloproliferative disease;Natural Killer Cells;novel;Oral;Outcome;Outpatients;Pancytopenia;participant enrollment;Pathway interactions;Patient Compliance;Patients;Pattern;Pattern Recognition;peripheral blood;Persons;Pharmaceutical Preparations;Physicians;Population;Pregnancy;prevent;Prevention trial;programs;progression risk;Proteomics;Protocols documentation;Publications;Pure Red-Cell Aplasia;Race;receptor;Recovery;Refractory;Refractory anemias;Regimen;Regulatory T-Lymphocyte;Relapse;relapse prevention;Reporting;Research;response;Risk;Risk Factors;sample collection;Sample Size;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Sirolimus;Specificity;standard of care;Stem cell transplant;stem cells;Survival Rate;T cell clonality;T-Cell Receptor;Techniques;telomere;Testing;Therapeutic immunosuppression;Thrombopoietin;Time;Toxic effect;Transplantation;Treatment Efficacy;Treatment Protocols;Twin Multiple Birth;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Immune Pathophysiology of Aplastic Anemia and Immunosuppressive Treatments


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Gene Therapy;Genetics;Hematology;Infectious Diseases;Neurosciences;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: DUNBAR, CYNTHIA E (contact)

PROJECT_TERMS: Aging;Alzheimer's disease risk;Amyloid;Animal Model;animal old age;Animals;Bar Codes;base editing;Biology;Blood;Blood Cells;Blood Platelets;Brain;cardiovascular disorder risk;CD34 gene;Cell Count;Cells;Clinic;Clinical;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Control Animal;COVID-19;COVID-19 severity;CRISPR/Cas technology;Disease;disease model;DNA Double Strand Break;Engineering;Engraftment;Failure;functional loss;gene correction;gene therapy;gene-editing approach;gene-targeted therapy;Generations;Genes;Genetic;Genetic Diseases;genome editing;genotoxicity;Hematopoiesis;Hematopoietic stem cells;Human;human disease;human model;improved;Inflammatory;Inherited;insertion/deletion mutation;Knock-out;Laboratories;lentiviral integration;Lentivirus Vector;leukemia;Link;loss of function;loss of function mutation;Lung;Macaca;Macaca mulatta;Marrow;Mediating;Microglia;Modeling;Modification;mouse model;mutant;Mutate;Mutation;Myeloid Cells;Nonhomologous DNA End Joining;Normal Cell;Other Genetics;Outcome;patient prognosis;Phenotype;Pilot Projects;Pre-Clinical Model;predictive test;Predisposition;prevent;Prognosis;repaired;Reporting;Research;Rhesus;Rodent Model;RUNX1 gene;Safety;SARS-CoV-2 infection;severe COVID-19;Syndrome;System;targeted sequencing;targeted treatment;tau Proteins;therapeutic genome editing;Time;Tissues;Toxic effect;Virus;Work

PROJECT_TITLE: Optimization of genetic modification of HSCs in the NHP model and creation of relevant preclinical models of human disease and therapies


NIH_SPENDING_CATS: Brain Disorders;Cancer;Clinical Research;Genetics;Lung;Lymphatic Research;Rare Diseases;Tuberous Sclerosis;Women's Health Research

PROJECT_TERMS: 9-cis-retinal;Abdomen;Actins;Affect;African American;age related;Agreement;aldehyde dehydrogenases;alitretinoin;Alveolar Macrophages;alveolar type II cell;Amino Acids;Angiomyolipoma;Antibodies;Asian;autosome;Benign;Binding;Biological Assay;Biological Markers;Biological Process;Blood;Blood Vessels;Body Fluids;C-terminal;caldesmon;Cardiac Myocytes;Cell Cycle;Cell Differentiation process;Cell Nucleus;Cell Physiology;Cell Proliferation;Cell Separation;Cell Shape;cell type;Cells;chemokine receptor;clinical center;Clone Cells;Complement Factor H;Cultured Cells;Cyclic AMP;Cytoplasm;Cytostatics;Data;density;deprivation;Detection;Diagnosis;Disease;Disease Progression;Disease susceptibility;effusion;endoplasmic reticulum stress;Ethnic Origin;Exhibits;Family;Fibroblasts;FRAP1 gene;Frequencies;Gene Expression;gene product;Genes;Genetic;Genetic Diseases;Genetic Heterogeneity;Genetic Transcription;Growth;Helix-Turn-Helix Motifs;Homo;Hyperplasia;Hypoxia;Hypoxia Inducible Factor;Immune;improved;Inflammation;inhibitor;Invaded;Isotretinoin;Lasers;Lead;Length;Leucine Zippers;Loss of Heterozygosity;Lung;Lung Diseases;lung lesion;Lung Lymphangioleiomyomatosis;Lung nodule;Lung Transplantation;Lymphangioleiomyomatosis;Lymphangiomyoma;Lymphatic;Lymphatic Endothelium;Lymphocyte;male;Malignant Neoplasms;MART-1 Tumor Antigen;mast cell;Measures;Mediating;Meditation;melanocyte;Melanogenesis;Melanoma;Melanoma Cell;Melanosomes;member;Messenger RNA;Metabolism;metastatic process;microphthalmia-associated transcription factor;Molecular Abnormality;Molecular Target;Monoclonal Antibodies;Monophenol Monooxygenase;Motility;Movement;multi-racial;Multivariate Analysis;Mutation;MYO5A gene;Myofibroblast;Neoplasm Metastasis;Nodule;Nuclear Proteins;Nutrient;Organ;Pathogenesis;patient population;Patients;Pattern;PAX3 gene;Pharmaceutical Preparations;Phenotype;Play;Pneumothorax;Process;Proliferating;promoter;Promoter Regions;Protein Isoforms;Proteins;Publishing;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Quality of life;Reaction;Regulation;Reporting;Resolution;Retina;Retinoic Acid Receptor;Reverse Transcriptase Polymerase Chain Reaction;Role;RXR;Sampling;SDZ RAD;Serum;Shapes;SILV gene;Sirolimus;skin lesion;Smooth Muscle;Smooth Muscle Myocytes;Sorting;Structure;Structure of parenchyma of lung;Syndrome;System;Testing;Therapeutic Trials;Time;Tissues;Transcript;transcription factor;Transcriptional Regulation;Tretinoin;TSC1 gene;TSC1/2 gene;TSC2 gene;Tuberous Sclerosis;tumor;Tumor Suppressor Genes;TYRP1 gene;Undifferentiated;United States National Institutes of Health;Urine;vesicle transport;Visit;Vitamin A;Western Blotting;Woman

PROJECT_TITLE: Characterization of the Pathogenesis of Lymphangioleiomyomatosis (LAM)


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

PROJECT_TERMS: Actins;Atomic Force Microscopy;Biological Assay;Chemicals;Complex;Disease;Electron Microscopy;Environment;F-Actin;Goals;Image Analysis;Length;Mechanics;Microfilaments;microscopic imaging;Microscopy;Molecular;Molecular Motors;Motility;Motion;Motor;Myosin ATPase;Myosin Type V;nanometer;optic trap;optical traps;Optics;Output;particle;Property;Regulation;Resolution;single molecule;Structure;Techniques;Total Internal Reflection Fluorescent;Walking

PROJECT_TITLE: Studies Of Myosin V


PROJECT_TERMS: Actins;Adaptor Signaling Protein;Affinity;Amino Acids;arm;Auditory;Behavior;Binding;Biochemical;Biological;Biological Assay;biophysical techniques;Calmodulin;Cells;Cochlea;Collaborations;Complement;Complex;Deafblind;design;differential expression;Dimerization;Drosophila genus;Electrons;force sensor;Glass;Goals;Hearing;Holoenzymes;Human;Image Analysis;In Vitro;in vivo;Infection;Insecta;Kinetics;Light;Link;Lipid Bilayers;Malaria;mechanical properties;member;Membrane;Membrane Proteins;Microfilaments;microscopic imaging;Mitochondria;Molecular;monomer;Motility;Motor;mutant;Mutation;Myosin ATPase;Nonmuscle Myosin Type IIA;Orthologous Gene;paralogous gene;Parasites;particle;Plasmodium;Play;Process Measure;Property;Protein Isoforms;Proteins;Recombinant Proteins;Recombinants;reconstitution;Regulation;Regulatory Element;Research;RNA Splicing;Role;sensor;sensory system;single molecule;Slide;Structure;Surface;System;Universities;Usher Syndrome Type 1;Vermont;Vision

PROJECT_TITLE: Expression Studies of Other Unconventional Myosins


PI_NAMEs: LEDERMAN, ROBERT J (contact)

PROJECT_TERMS: Adopted;Adult;Biological;Cardiology;Cardiovascular system;Catheterization;Catheters;clinical application;clinical center;clinical development;clinical practice;Complex;Development;Devices;Disease;Educational process of instructing;Educational workshop;Europe;Femur;heart function;Human;Image;Intervention;Lesion;Lung;Magnetic Resonance Imaging;Measures;Mechanics;Medical center;Myocardial;North America;novel;Patients;Performance;Pulmonary Artery Catheterization;Radiation;radio frequency;Research;System;Techniques;Time;United States National Institutes of Health;Water;Work;X-Ray Medical Imaging

PROJECT_TITLE: MRI cardiovascular catheterization applications


PI_NAMEs: HWANG, PAUL M. (contact)

PROJECT_TERMS: Affect;bench to bedside;Biology;cancer prevention;cardiovascular health;Cardiovascular system;Chemoprevention;chemotherapy;Chronic;Clinical Research;Collaborations;Disease;early onset;Extramural Activities;Fatigue;Germ-Line Mutation;Heart Diseases;insight;interest;Investigation;Laboratories;Li-Fraumeni Syndrome;Malignant Neoplasms;Mediator;Metabolism;Metformin;Mitochondria;mitochondrial metabolism;Molecular;mouse model;mutant mouse model;novel;Patients;prevent;Regulation;Research Personnel;Role;TP53 gene;translational study;tumorigenesis

PROJECT_TITLE: Mitochondrial regulation and function in cancer and cardiovascular biology


PI_NAMEs: SACK, MICHAEL  (contact)

PROJECT_TERMS: Bioinformatics;biological systems;Caloric Restriction;CD4 Positive T Lymphocytes;Cells;Clinical;detection of nutrient;Disease;Fasting;Homeostasis;Human;Immune;immune function;Immune system;Immunity;immunoregulation;Inflammation;Inflammatory;Link;Mediating;Metabolic Pathway;Metabolism;metabolomics;mimetics;Mitochondria;monocyte;novel;Pathway interactions;Play;Proteomics;Regulation;Regulatory Pathway;Role;transcriptome sequencing;Work

PROJECT_TITLE: Metabolic pathways linked to immunity


NIH_SPENDING_CATS: Bioengineering;Cancer;Genetics;Skin Cancer;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Wound Healing and Care

PI_NAMEs: WATERMAN, CLARE MICHAL (contact)

PROJECT_TERMS: 3-Dimensional;Actins;Actomyosin;Adaptor Signaling Protein;Adhesions;Adhesives;Adopted;advanced prostate cancer;Aneurysm;Apical;Area;Atherosclerosis;Back;Binding Proteins;Biochemical;Biological Models;biophysical techniques;Biophysics;Blood Vessels;Breast;Bulla;Burn injury;Cadherins;cancer cell;Cardiovascular Diseases;CASP1 gene;CD44 gene;Cell Adhesion;cell behavior;Cell Culture Techniques;Cell Cycle Progression;Cell Death;Cell Line;Cell membrane;cell motility;Cell Nucleus;Cell Polarity;Cell Shape;Cells;Centrosome;Cessation of life;Chemotaxis;Cholesterol;chromatin remodeling;Collaborations;Complex;constriction;cytokine;Cytoskeleton;Decision Making;Defect;Development;Diameter;Disease;Disease Progression;Disseminated Malignant Neoplasm;Dissociation;Drug Targeting;EGF gene;Embryonic Development;emerin;endothelial dysfunction;Endothelium;Engineering;Epidermal Growth Factor Receptor;Epigenetic Process;Event;Exhibits;experience;Extracellular Matrix;Failure;first responder;Focal Adhesions;Friction;Generations;Genes;Genetic Heterogeneity;Goals;Growth Factor;Growth Factor Receptors;Hemorrhage;Host Defense;Human;Human Resources;IL18 gene;Image;Immune response;Immune System Diseases;In Vitro;in vitro Model;Infection;Inflammasome;Inflammation;Inflammatory;Inherited;Innate Immune System;innovative technologies;insight;Integrins;lamin B receptor;Lasers;Leukocytes;Leukotriene B4;light microscopy;Liver;Lytic;malformation;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Measures;mechanical signal;mechanical stimulus;Mechanics;mechanotransduction;Mediating;melanocyte;Melanoma Cell;Membrane;Metastatic Melanoma;Microfilaments;Microtubule-Organizing Center;Microtubules;migration;Modeling;Molecular;Monitor;Monomeric GTP-Binding Proteins;Morphogenesis;Morphology;Mouse Embryonic Stem Cells;Movement;Mus;nanoscale;natural Blastocyst Implantation;Nervous System;neutrophil;Neutrophil Infiltration;Nuclear;Nuclear Envelope;Organelles;Output;overexpression;Oxidoreductase;Pathology;Pathway interactions;Patients;Peptide Hydrolases;Permeability;Phagocytosis;Phosphotransferases;physical process;Physical shape;Physiological;pluripotency;Pluripotent Stem Cells;polarized cell;Polymers;Printing;Process;programs;Proliferating;Prostate;protein protein interaction;Proteins;Pulse Rates;Pump;receptor;receptor expression;recruit;Regulation;Research;Resolution;response;Role;Scaffolding Protein;segregation;self organization;sensor;Shapes;Signal Transduction;Site;Small Interfering RNA;small molecule inhibitor;SOX1 gene;Speed;Sterols;Stimulus;Stress;Stroke;Study models;Surface;Syndrome;System;temporal measurement;Testing;three dimensional cell culture;Time;tissue culture;Transcriptional Activation;Translating;transmission process;treatment strategy;tumor;tumor progression;Up-Regulation;Vascular Diseases;Vascular System;Work;wound;wound healing

PROJECT_TITLE: Cell Migration in 3D microenvironments


PROJECT_TERMS: 3-Dimensional;Actins;Adhesions;Adhesives;Adopted;Binding;Biochemical;biophysical techniques;C-terminal;Cadherins;CDC2 gene;Cell Adhesion;cell behavior;cell cortex;Cell Culture Techniques;Cell Cycle Progression;Cell membrane;cell motility;Cell Nucleus;Cell Shape;Cells;Cessation of life;Collaborations;Cyclin B;Cytoskeleton;Data;Decision Making;Development;Dissociation;Drops;Drug usage;Embryonic Development;Environment;Event;Excision;Extracellular Matrix;ezrin;Family;Fibroblasts;Focal Adhesions;Friction;Gene Expression;Generations;Goals;Human Resources;Immune response;Immune System Diseases;innovative technologies;insight;Integrins;light microscopy;link protein;Malignant Neoplasms;Measurement;Measures;mechanical properties;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Membrane;Microfilaments;Microtubules;migration;mimetics;Mitosis;Mitotic;Modulus;moesin;Molecular;Molecular Biology;Morphogenesis;Morphology;Mutate;N-terminal;nanoscale;Nervous System;Nuclear;Nuclear Translocation;Organelles;Output;Pathway interactions;Phagocytosis;Phase;Phosphatidylinositol 4,5-Diphosphate;Phosphorylation;Phosphotransferases;Physical condensation;physical process;Physiological;Plasma Cells;polarized cell;polyacrylamide;Polymers;Process;programs;Proliferating;Prophase;Protein Family;protein protein interaction;Proteins;radixin protein;Regulation;Research;Resolution;response;rho;Role;self organization;Signal Pathway;Silicones;Site;Sorting;Stimulus;Surface;Techniques;temporal measurement;tensin;Testing;Time;Traction;Translating;transmission process;Variant;Vascular Diseases;Vascular System;wound healing

PROJECT_TITLE: Integration of Actin Dynamics and Adhesion in Cell Migration


NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition

PROJECT_TERMS: Acetyltransferase;Biology;Calcium;Deacetylase;design;detection of nutrient;Development;Diabetes Mellitus;Disease;Endoplasmic Reticulum;Endosomes;Functional disorder;functional genomics;genetic regulatory protein;Gluconeogenesis;Goals;in vivo;Insulin Resistance;Laboratories;Link;Lipids;Lysine;Lysosomes;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modification;mouse model;Nutrient;Obesity;Phenotype;Post-Translational Protein Processing;protein function;Proteins;Quality Control;Regulation;Role;ubiquitin ligase;Work

PROJECT_TITLE: Metabolic Regulation in the Pathophysiology of Disease


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: LEONARD, WARREN J (contact)

PROJECT_TERMS: Adoptive Transfer;Adult T-Cell Leukemia/Lymphoma;aerobic glycolysis;Affinity;Agonist;Allergic;Antibodies;Antitumor Response;Autoimmune;Autoimmune Diseases;B-Lymphocytes;Binding;Biological;Biology;CD27 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell type;Cells;chimeric antigen receptor T cells;ChIP-seq;Chromatin;Chromatin Interaction Analysis by Paired-End Tag Sequencing;Citric Acid Cycle;Closure by clamp;CRISPR/Cas technology;cytokine;Cytokine Receptors;Data;Development;differentiation in vitro;dimer;Dimerization;Disease;effector T cell;Elements;Engineering;Enhancers;Event;exhaustion;exosome;Experimental Autoimmune Encephalomyelitis;Family;Gene Expression Regulation;Generations;Genes;genetic analysis;genome-wide;Genomic approach;Goals;graft vs host disease;Granulocyte-Macrophage Colony-Stimulating Factor;Haplotypes;Helminths;Host Defense;Human;human disease;Human T-lymphotropic virus 1;IFNG gene;IL2RA gene;IL4R gene;IL6ST gene;IL7 gene;Immune checkpoint inhibitor;Immune response;immune system function;immunodeficiency;in vivo;Inbred Strains Mice;Induction of Apoptosis;Inflammatory;Inflammatory Bowel Diseases;insight;interest;Interferons;Interleukin 2 Receptor;Interleukin 2 Receptor Gamma;Interleukin-15;interleukin-15 receptor;Interleukin-2;interleukin-21;interleukin-21 receptor;Interleukin-4;Interleukin-9;IRF4 gene;Knock-in Mouse;Lactate Dehydrogenase;Legal patent;LIM Domain;Maintenance;Malignant Neoplasms;Mediating;Melanoma;member;Memory;Metabolism;Methodology;Modeling;Molecular;monocyte;Mus;Mutate;Names;Natural Killer Cells;neuroinflammation;novel;novel diagnostics;novel strategies;novel therapeutics;Nuclear Family;Nuclear Receptors;Oncogenic;Outcome;Oxidative Phosphorylation;pathogen;Pathologic;Phenotype;Physiological;Play;PRDM1 gene;prevent;Production;Proliferating;promoter;Promoter Regions;Protein Engineering;Protein Family;Proteins;Proto-Oncogene Proteins c-jun;Pyruvate;receptor;Receptor Signaling;Regulation;Regulatory T-Lymphocyte;Reporting;Repression;response;Role;Severity of illness;Shapes;Signal Induction;Signal Transduction;STAT protein;STAT1 gene;STAT3 gene;Stat5 protein;STAT5B gene;stem cells;stemness;synergism;System;T cell differentiation;T memory cell;T-Cell Activation;T-Lymphocyte;Th1 Cells;Th2 Cells;Time;TP53 gene;Transcription Factor AP-1;Transgenic Mice;translational potential;Transplantation Tolerance;tumor;Tyrosine Phosphorylation;Variant;Virus;X-Linked Severe Combined Immunodeficiency;XBP1 gene

PROJECT_TITLE: IL-2 Family Cytokines and their Receptors-- Biology of the IL-2 system


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Rare Diseases

PROJECT_TERMS: 3-Dimensional;Adoptive Transfer;adult T-cell leukemia cell;Adult T-Cell Leukemia/Lymphoma;Affect;Agonist;Allergic;Alopecia;Attenuated;Autoimmune;Autoimmune Diseases;Axon;B-Lymphocytes;BCL6 gene;Binding;Biological;Biological Process;biomarker discovery;CD27 Antigens;CD8-Positive T-Lymphocytes;Cell Adhesion Molecules;Cell Differentiation process;Cell Physiology;cell type;Cells;chimeric antigen receptor T cells;chromatin immunoprecipitation;Chromatin Structure;Clathrin;Closure by clamp;Collaborations;Coupled;CRISPR/Cas technology;cytokine;Cytokine Receptors;Data;Defect;Dendritic Cells;Development;dimer;Disease;DNA sequencing;Down-Regulation;effector T cell;EGR2 gene;Elements;Endocytosis;Enhancers;epigenome;Event;exhaustion;Eyelid structure;Family;Functional disorder;Gene Expression;Genes;Genetic;Genetic Enhancer Element;Genetic Transcription;genome-wide;Goals;graft vs host disease;Granulocyte-Macrophage Colony-Stimulating Factor;Helminths;Helper-Inducer T-Lymphocyte;Homing;Host Defense;Human;human disease;Human T-lymphotropic virus 1;IL2 gene;IL2RA gene;IL7 gene;Imides;Immune;Immune response;immune system function;immunodeficiency;Immunologics;immunoregulation;in vivo;Inbred BALB C Mice;Induction of Apoptosis;Inflammatory;insight;Interleukin 2 Receptor;Interleukin 2 Receptor Gamma;Interleukin 4 Receptor;Interleukin-15;interleukin-15 receptor;Interleukin-2;interleukin-21;interleukin-21 receptor;Interleukin-4;Interleukin-9;IRF4 gene;Knock-in Mouse;Link;Malignant - descriptor;Malignant Neoplasms;Maps;Mediating;Melanoma;mimetics;Modeling;Molecular;monocyte;Multiple Myeloma;multiple omics;Mus;mutant;Mutate;myelination;Names;Natural Killer Cells;novel;novel diagnostics;novel strategies;novel therapeutics;pathogen;Pathogenicity;Pathologic;Peripheral;Pharmaceutical Preparations;Phenotype;Physiological;Population;PRDM1 gene;Proliferating;promoter;protein activation;protein expression;Protein Family;Proteins;Proto-Oncogene Proteins c-jun;receptor;receptor expression;Receptor Signaling;Regulation;Regulatory T-Lymphocyte;Reporting;Repression;response;Response Elements;Role;Schwann Cells;Signal Induction;Signal Transduction;STAT protein;STAT1 gene;STAT3 gene;Stat5 protein;STAT5B gene;System;T-Cell Activation;T-Lymphocyte;Therapeutic;three dimensional structure;thymocyte;Thymus Gland;Time;transcription factor;Transcription Factor AP-1;transcriptome sequencing;Transgenic Mice;tumor;Tyrosine Phosphorylation;user-friendly;Variant;Virus;X-Linked Severe Combined Immunodeficiency

PROJECT_TITLE: IL-2 Family Cytokines and Receptors-- Mechanisms of Regulation & Action


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Immunotherapy

PROJECT_TERMS: Adoptive Transfer;aerobic glycolysis;angiogenesis;anti-tumor agent;Antigens;Antineoplastic Agents;Antitumor Response;Apoptosis;Autoimmune Diseases;autoimmune uveitis;Autoimmunity;autosome;B-Cell Activation;B-Lymphocytes;BCL2L11 gene;Biological;Biology;CD27 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;Cell Survival;cell type;Cells;Cellular immunotherapy;Chronic;Citric Acid Cycle;Collaborations;Collagen Arthritis;cytokine;Cytokine Receptors;cytotoxic;Dendritic Cells;Development;Disease;Dose;Elements;Endothelial Cells;Endothelium;Environment;Event;exhaustion;Exhibits;exosome;extracellular vesicles;Family;gain of function;Genes;Glucocorticoids;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Granzyme;Helper-Inducer T-Lymphocyte;Hindlimb;Human;human disease;Hyper-IgE Syndrome;Hypoxia;IL7 gene;IL7R gene;Immune;Immune response;immune system function;immunodeficiency;Immunoglobulins;Impairment;Induction of Apoptosis;Infection;Insulin-Dependent Diabetes Mellitus;interest;Interferon Type II;Interferons;Interleukin 2 Receptor;Interleukin 2 Receptor Gamma;Interleukin-1;Interleukin-10;Interleukin-15;Interleukin-2;interleukin-21;interleukin-21 receptor;Interleukin-4;Interleukin-9;IRF4 gene;Ischemia;ITGAX gene;JAK3 gene;Knockout Mice;Knowledge;Laboratories;Lactate Dehydrogenase;Legal patent;LIM Domain;Lupus;Lymphocytic choriomeningitis virus;Lymphopenia;Malignant Neoplasms;Mediating;Mediator;Memory;Metabolism;MicroRNAs;mimetics;mouse model;mRNA Expression;Murine pneumonia virus;Mus;Mutate;Mutation;Names;Natural Immunity;Natural Killer Cells;neoplastic;neoplastic cell;neutrophil;NF-kappa B;novel;novel diagnostics;novel therapeutics;Nuclear Family;Nuclear Receptors;Pathogenicity;Pathologic;Pathway interactions;Patients;Perfusion;Peripheral arterial disease;Phenocopy;Phenotype;Phosphotransferases;Physiological;PRDM1 gene;prevent;Process;Production;programs;Proliferating;Property;Proteins;Proto-Oncogene Proteins c-jun;Pyruvate;receptor;Receptor Activation;receptor expression;Recovery;Reporting;response;Role;Signal Induction;Signal Transduction;Staphylococcus aureus;STAT1 gene;STAT3 gene;stem cells;System;T cell differentiation;T memory cell;T-Lymphocyte;Therapeutic;Time;Transcription Factor AP-1;Transgenic Organisms;translational potential;tumor;Tumor Immunity;Uveitis;Work;X-Linked Severe Combined Immunodeficiency;XBP1 gene

PROJECT_TITLE: IL-2 Family Cytokines and their Receptors-- Biology of the IL-21 system