NIH_SPENDING_CATS: Data Science;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Sepsis

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Personalized medicine holds the promise of improving care for patients with severe infections (sepsis). Glucocorticoids (often referred to as steroids) are commonly used in the treatment of septic patients, but it is unclear which patients benefit and which patients may be harmed. We will use datasets and blood samples from several US and international studies with novel machine learning assisted mathematical techniques to develop approaches that will help doctors personalize steroids for septic patients.

PI_NAMEs: ANGUS, DEREK C;YENDE, SACHIN  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;Affect;Algorithms;American;Bayesian Modeling;Bayesian Network;biobank;Biological;Biological Assay;Biological Markers;Blood specimen;Calibration;Caring;Cessation of life;Clinical;Clinical Data;clinical decision support;clinical practice;cohort;Collaborations;comorbidity;Computing Methodologies;Critical Care;cytokine;Data;data integration;Data Set;demographics;design;Development;Disease;efficacy testing;Electronic Health Record;Emergency Care;Etiology;Functional disorder;Future;Glucocorticoids;Goals;Heterogeneity;Hospitals;improved;improved outcome;Individual;individualized medicine;Infection;innovation;International;knowledge network;Machine Learning;Mathematics;Methods;Modeling;mortality;multidisciplinary;novel;optimal treatments;Organ;Patient Care;Patients;Pattern;personalized medicine;Phenotype;Policies;pre-clinical therapy;precision medicine;Precision therapeutics;predictive modeling;Prognosis;Randomized;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;response;Risk;Risk Reduction;Sampling;secondary analysis;Sepsis;septic patients;Septic Shock;Serum;Source;Specialist;Steroids;success;supervised learning;support tools;Techniques;Testing;transcriptome sequencing;transcriptomics;Translating;treatment effect;treatment response;United States;unsupervised learning;Whole Blood

PROJECT_TITLE: Precision Medicine Approach to Glucocortisteroids in Sepsis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: DC

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Dystonia;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Rehabilitation

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: PROJECT NARRATIVE  The proposed research aims to assess the feasibility and efficacy of adaptive brain-computer interface neurotechnology for a novel pathophysiologically based therapeutic intervention in patients with laryngeal dystonia. The proposed research is relevant to public health because non-invasive neuromodulation of brain abnormalities that are specifically linked to the pathophysiology of laryngeal dystonia is ultimately expected to lead to the establishment of a new direction for the treatment of this debilitating disorder. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to developing and applying fundamental knowledge that will help reduce the burdens of human disability.

PI_NAMEs: SIMONYAN, KRISTINA  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Affect;botulinum neurotoxin injection;Botulinum Toxins;Brain;brain abnormalities;brain based;brain computer interface;Brain imaging;Characteristics;Chronic;Clinical;clinical care;Clinical Management;Clinical Trials;Communication;Crying;Data;design;Development;Diagnostic;disability;Disease;Disease Management;Double-Blind Method;Dystonia;Electroencephalography;Experimental Designs;Focal Dystonias;Foundations;Functional disorder;goal oriented behavior;Goals;Human;imaging study;Impairment;improved;Individual;Inferior;innovation;Intervention;Knowledge;Laryngeal muscle structure;Larynx;Learning;Life;Link;Methodology;Mission;Motor;motor behavior;motor control;motor deficit;motor impairment;motor rehabilitation;motor symptom;Movement;multimodality;Muscle Contraction;Nervous System Disorder;neural;neural patterning;neurofeedback;neuroregulation;neurotechnology;novel;novel therapeutic intervention;novel therapeutics;Occupational;optimal treatments;Outcome;Parietal;Patients;Pattern;Peripheral;Phase;Phase I Clinical Trials;Physiology;Posture;Production;psychiatric comorbidity;psychologic;Public Health;Quality of life;Randomized;reduce symptoms;Rehabilitation therapy;Research;side effect;skills;Social isolation;Spasm;Spastic Dysphonias;Specificity;Speech;Stress;Symptoms;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;tool;translational impact;treatment strategy;United States National Institutes of Health;Voice

PROJECT_TITLE: Adaptive closed-loop brain-computer interface therapeutic intervention in laryngeal dystonia


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Aging;Dental, Oral, and Craniofacial Disease;Genetics;Hematology;Human Genome;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative More than 10% of adults over 70, have a somatic mutation in their blood stem cells, a newly identified disease termed ‘Clonal Hematopoiesis of Indeterminate Potential’ (CHIP), which increases blood cancer risk by 10-fold, heart attack risk by 2-fold and risk of death by 1.5-fold. To understand the fundamental causes and disease consequences of CHIP, we will perform human genomic analyses of hundreds of thousands of individuals with and without CHIP. Our work identifying the causes of CHIP may lead to the first treatment for patients with CHIP that would prevent multiple age-associated diseases.

PI_NAMEs: BICK, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Acceleration;Adult;Age;age-related disease;Aging;aging related disease;Biological;Biology;cancer risk;Cardiovascular Diseases;Cardiovascular system;career;Chronic Disease;Clinical Medicine;Clonal Expansion;cohort;Communities;Computing Methodologies;Data;Development;Disease;Disease Outcome;disorder risk;DNMT3a;Environmental Risk Factor;experimental study;follow-up;Funding;Gene Expression;Genes;genetic approach;genetic association;Genetic Variation;Genome;genome resource;genome sequencing;genome wide association study;Genomics;Germ Lines;Germ-Line Mutation;Hematopoiesis;Hematopoietic Neoplasms;Hematopoietic stem cells;Human;Human Genetics;human genomics;IL-6 inhibitor;IL6 gene;In Vitro;Individual;insight;Institution;Interleukin-6;Internal Medicine;Intervention;JAK2 gene;Malignant Neoplasms;Mediating;Mentorship;Methods;Minority;mortality risk;mouse model;Mutation;Myocardial Infarction;National Heart, Lung, and Blood Institute;novel;Pathway interactions;Patients;Population;Positioning Attribute;Precision therapeutics;prevent;Prevention;programs;protective pathway;Research;Residencies;Resources;Risk;Risk Factors;Sampling;Signal Transduction;single-cell RNA sequencing;skills;Somatic Mutation;stem cell function;Testing;Therapeutic;therapeutic target;Time;Training;Trans-Omics for Precision Medicine;transcriptome sequencing;Variant;Whole Blood;Work

PROJECT_TITLE: Targeting Clonal Hematopoiesis of Indeterminate Potential using Human Genetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)R]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Women's Health Research

ORG_CITY: COLLEGE PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Recent studies have indicated that mechanical cues from the cell's environment are indispensable for key processes such as development and wound healing. Changes in the mechanical properties of tissues are reliable markers of disease – for example tissue density is one of the strongest risk factors in cancer progression, while immune cells exploit mechanical signals to kill cancer cells. How mechanical cues regulate cell function remains poorly understood. The proposed research to develop fundamental understanding of how mechanical stimuli and cell generated forces regulate T cell signaling and killing of tumor cells as well as the dynamics of gene expression will have important implications for the development of new therapeutic avenues for immunotherapies and diagnostic tools for diseases like breast cancer.

PI_NAMEs: UPADHYAYA, ARPITA  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Actins;adaptive immune response;Address;Adhesions;Binding;Biochemical;Biophysical Process;cancer cell;Cell Communication;cell killing;Cell Nucleus;Cell Physiology;Cells;Chromatin;Coupled;Cues;cytokine;Cytoskeleton;Cytotoxic T-Lymphocytes;Data;density;design;Development;diagnostic tool;Disease;Disease Marker;Environment;flexibility;Funding;Funding Mechanisms;Gene Expression;Gene Expression Regulation;Generations;Genetic Transcription;genome-wide;Genomics;Goals;Image;Image Analysis;Immune;Immune response;Immunotherapy;Intervention;Kinetics;Lymphocyte Activation;Malignant Breast Neoplasm;mathematical model;Measurement;mechanical force;mechanical properties;mechanical signal;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Methods;Microtubules;Molecular;Movement;National Institute of General Medical Sciences;Nature;neoplastic cell;novel therapeutics;Nuclear Hormone Receptors;Process;programs;quantitative imaging;Receptor Signaling;Research;Resolution;response;Risk Factors;Signal Transduction;single molecule;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Technology;Time;Tissues;tool;Transcription Coactivator;transcription factor;Transcriptional Regulation;tumor progression;Visualization;wound healing

PROJECT_TITLE: Cellular mechanotransduction - from the immune response to transcriptional regulation

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Parkinson's Disease;Sleep Research

ORG_CITY: Scottsdale

ORG_NAME: CND LIFE SCIENCES, INC.

ORG_STATE: AZ

PHR: PROJECT NARRATIVE A group of neurodegenerative diseases, termed synucleinopathies, have no existing disease modifying thera- pies, affect over 2 million people in the U.S. and share an underlying pathology—progressive deposition of phos- phorylated α-synuclein protein in the central and peripheral nervous systems. In the proposed study, CND Life Sciences will advance the diagnostic and commercial potential of its Syn-One Test™ that detects phosphorylated α-synuclein in small skin biopsies by focusing on a population of patients diagnosed with idiopathic rapid eye movement disorder (iRBD), >90% of whom will ultimately develop synucleinopathy 10-15 years following iRBD diagnosis. Successful completion of this study will enable the clinicians to utilize the Syn-One Test™ to deter- mine which of the iRBD patients will develop synucleinopathy, which type and how quickly, and aid in the devel- opment of therapies for this group of devastating diseases.

PI_NAMEs: LEVINE, TODD  (contact)

PROGRAM_OFFICER_NAME: AUBRECHT, TARYN GRACE

PROJECT_TERMS: Academia;Acceleration;accurate diagnostics;Address;Affect;alpha synuclein;American;Artificial Intelligence enhanced;behavior disorder diagnosis;Biological Sciences;Biopsy;Blinded;Central Nervous System;circulating biomarkers;CLIA certified;Clinical;Clinical Trials;Cognitive;Collaborations;companion diagnostics;Cutaneous;Data;deep learning algorithm;Dementia with Lewy Bodies;Deposition;Detection;detection platform;Development;Diagnosis;Diagnostic;Diagnostic tests;diagnostic tool;diagnostic value;digital;Disease;Disease Progression;disorder control;Dreams;effective therapy;Feasibility Studies;follow-up;Funding;Future;Health Care Costs;imaging approach;improved;Industry;innovation;Laboratories;laboratory experience;Location;Measurement;Measures;Methodology;Methods;minimally invasive;misfolded protein;Modeling;Morbidity - disease rate;mortality;Motor;Movement;Multiple System Atrophy;Nerve Degeneration;Nerve Fibers;neural;Neurodegenerative Disorders;Neurologist;Neurology;Ocular Motility Disorders;Parkinson Disease;participant enrollment;Pathologic;Pathologist;Pathology;Patient Care;patient population;Patients;Pattern Recognition;Peripheral Nervous System;Persons;phase 2 study;Phosphorylation;Pilot Projects;Probability;Proteins;Public Health;public-private partnership;Punch Biopsy;Pure Autonomic Failures;rapid eye movement;Reading;REM Sleep Behavior Disorder;Reproducibility;Risk;Sensitivity and Specificity;Severity of illness;skin biopsy;Stains;Structure;success;Surrogate Endpoint;Symptoms;synuclein;synucleinopathy;Technology;Testing;therapy development;Time;United States National Institutes of Health;Visual;vocalization;whole slide imaging

PROJECT_TITLE: Cutaneous Phosphorylated Alpha-Synuclein for Detection of Prodromal Synucleinopathies


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: Aurora

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE ROCKY MOUNTAIN CANNABIS RESEARCH CENTER (RM-CRC) Recreational and medical cannabis products that contain varying amounts of tetrahydrocannabinol (THC) and cannabidiol (CBD) are now widely available throughout North America. Despite these changes, research on the effects of THC and CBD has been lacking. The central goals of this Research Center of Excellence application are to evaluate, in three research projects that span emerging, middle-aged, and older adults, how CBD affects the use of and subjective response to THC, and whether these effects are mediated by the endocannabinoid system (ECS) and associated lipids.

PI_NAMEs: HUTCHISON, KENT E. (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Acute;Adolescence;Adult;Affect;age group;Behavior;behavior measurement;Behavioral;behavioral outcome;Biological;Biological Assay;Biological Markers;Blood;Blood specimen;Cannabidiol;Cannabinoids;Cannabis;Centers of Research Excellence;Communities;Data;Data Analyses;data cleaning;Data Collection;data harmonization;Data Set;data sharing;design;District of Columbia;Dose;emerging adult;Endocannabinoids;endogenous cannabinoid system;Epidiolex;experience;Foundations;Funding;Future;Goals;Health;Hemp;Industry;innovation;Knowledge;Laboratories;Legal;Legal Status;life span;lipid mediator;Lipids;Machine Learning;Measures;Mediating;Medical Marijuana;middle age;Modeling;Moods;Neurocognition;Neurocognitive;North America;novel;older adult;Outcome;Participant;Pharmacologic Substance;Pharmacology;Pharmacy facility;Pilot Projects;Placebos;Public Health;Randomized;Recreation;repository;Research;Research Project Grants;Resources;response;Risk;Sampling;Scientist;Self Administration;Structure;success;System;Terpenes;Tetrahydrocannabinol;Time;United States;United States National Institutes of Health;user-friendly;web based interface

PROJECT_TITLE: Rocky Mountain Cannabis Research Center


NIH_SPENDING_CATS: Cannabinoid Research;Drug Abuse (NIDA only);Substance Misuse

PROJECT_TERMS: Advisory Committees;Area;Cannabis;Colorado;Communication;Communities;Data;Data Analyses;data harmonization;data sharing;Development;Education;Education and Outreach;endogenous cannabinoid system;Ensure;equity, diversity, and inclusion;Funding;Future;Goals;Health;Human Resources;Lipids;Mediating;medical schools;meetings;member;outreach;Patient Recruitments;Pilot Projects;Productivity;Psychiatry;Recommendation;Research;Research Personnel;Research Project Grants;Resources;service utilization;Structure;Students;Universities;Work

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Dementia;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative  Many common and incurable diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases, are characterized by the accumulation and aggregation of misfolded proteins and the activation of cellular stress pathways. This proposal examines the mechanisms by which cells degrade these aggregation-prone proteins, and how stress pathways affect this process through the trafficking of degradative organelles. Understanding these fundamental cellular processes is essential for developing therapeutics that take advantage of the complicated relationships between stress pathways and neurodegenerative diseases.

PI_NAMEs: HOLLIEN, JULIE  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Affect;Alzheimer's Disease;Autophagocytosis;biological adaptation to stress;Brain;Cell Physiology;Cells;Cellular Stress;Data;design;Diabetes Mellitus;Disease;Endoplasmic Reticulum;endoplasmic reticulum stress;Goals;Homeostasis;human disease;Huntington Disease;Huntington gene;insight;late endosome;Lysosomes;Malignant Neoplasms;Mammalian Cell;Mediating;Messenger RNA;misfolded protein;Nerve Degeneration;Neurodegenerative Disorders;novel therapeutic intervention;Organelles;Parkinson Disease;Pathway interactions;Patients;Positioning Attribute;Process;protein aggregation;Proteins;Regulation;Research Proposals;response;Stress;Therapeutic;tool;trafficking

PROJECT_TITLE: Regulation of lysosome positioning and function by the unfolded protein response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Substance Misuse

PI_NAMEs: RIGGS, PAULA DEGRAFFENREID (contact)

PROJECT_TERMS: addiction;Address;Advisory Committees;Area;Award;Behavioral;Cannabis;career;career development;clinically relevant;Collaborations;Colorado;Communities;Consultations;Discipline;Environment;Faculty;Feasibility Studies;Fostering;Funding;Grant;Health;Home;Incubators;innovation;Institution;life span;marijuana use;Marketing;Medical;Medical Marijuana;medical schools;Medicine;Minority;outreach;Phase;Physiological;Pilot Projects;Procedures;Process;Qualifying;Recreation;recruit;Recruitment Activity;Research;research and development;Research Personnel;Research Project Grants;Research Proposals;Statutes and Laws;Talents;timeline;Underrepresented Populations;United States National Institutes of Health;Universities

PROJECT_TITLE: Pilot Project Core


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: COAST NARRATIVE If we validate an SLT treatment strategy that extends the duration of medication-free disease control, we move one step closer to the possibility of a drop-free lifetime for our patients. Delaying the need for medications by 3, or 5, or 7 years not only confers all the benefits of medication-freedom during this period (which will be all that many patients would need in their lifetimes)—it also allows time for development of safer and more effective drugs dosed infrequently via sustained-release delivery systems, as well as better surgical options, for patients whose lifespans exceed SLT responsiveness. Thus, a new treatment paradigm consisting of SLT, then sustained-release medications, then surgery, could offer the majority of glaucoma patients the very real possibility of a drop-free lifetime of therapy.

PI_NAMEs: GOUNDAPPA, BALASUBRAMANI K;WISNIEWSKI, STEPHEN R (contact)

PROGRAM_OFFICER_NAME: LE, JIMMY TOAN

PROJECT_TERMS: Adherence;aqueous;Argon;Cell Physiology;Cells;Clinical Research;comparative efficacy;Complex;Cornea;Data;Data Set;design;Development;disorder control;Dose;Drops;Effectiveness;Eye;Face;Failure;follow-up;Free Will;Freedom;Glaucoma;glaucoma surgery;Goals;Health;high risk;Human;Impairment;Inflammation;Italy;Laser Surgery;Lasers;life span;Light;Maintenance;Medical;minimally invasive;Molecular;Multi-Institutional Clinical Trial;Newly Diagnosed;novel therapeutics;Ocular Hypertension;Open-Angle Glaucoma;Operative Surgical Procedures;Outcome;Participant;Patient Compliance;Patients;Pattern;Pharmaceutical Preparations;Physiologic Intraocular Pressure;preservation;prevent;primary outcome;procedure safety;Process;Protocols documentation;Randomized;randomized trial;randomized, clinical trials;Regimen;response;Retreatment;Safety;Series;Shapes;Site;Specific qualifier value;Spottings;Survival Rate;Synthetic Prostaglandins;System;Therapy trial;Time;tissue culture;Titrations;Trabecular meshwork structure;Trabeculectomy;treatment strategy;Vision

PROJECT_TITLE: Clarifying the Optimal Application of SLT Therapy (COAST) Trial


ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative IRACDA at OHSU is a program that aims to train and support a diverse generation of future faculty, in partnership with Pacific University. IRACDA scholars will receive mentorship in conducting exceptional scientific research at OHSU, training and practice in evidence-based teaching methods at Pacific University, blended together by personalized career development and guidance from dedicated program staff at both institutions. As they grow through the program, IRACDA scholars will not only impact the future of science and education, but also will transform our existing programs and institutions.

PI_NAMEs: OZBURN, ANGELA RENEE (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Academia;Academic achievement;Academy;Basic Science;Biomedical Research;career;career development;Clinical Research;cohort;Communities;design;Development Plans;Educational Curriculum;Educational process of instructing;Ensure;Environment;Equilibrium;Ethnic Population;evidence base;experience;Faculty;Feedback;Fellowship;Funding;Grant;Growth;Health;improved;Individual;innovation;Institution;International;Investments;Manuscripts;Mentors;next generation;pedagogy;Positioning Attribute;Postdoctoral Fellow;Process;programs;racial population;recruit;Reproducibility;Research;Research Training;Science;Scientist;STEM field;success;symposium;tool;Training;Training Programs;Translational Research;Underrepresented Students;Universities;Work;Writing

PROJECT_TITLE: IRACDA at OHSU

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Aging;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Natural Products;Substance Misuse

PI_NAMEs: KLAWITTER, JOST  (contact)

PROJECT_TERMS: Alcohol consumption;Bar Codes;Behavioral;biobank;Biological Assay;Biological Markers;Cannabidiol;Cannabinoids;Cannabis;Categories;Clinical;Clinical Laboratory Information Systems;Clinical Trials;Collaborations;Computer software;Computerized Medical Record;Consumption;Data;Data Analyses;data harmonization;data management;Drug Exposure;Drug Interactions;Drug Kinetics;drug metabolism;Endocannabinoids;endogenous cannabinoid system;Energy Metabolism;Equipment and supply inventories;Evaluation;Event;Exposure to;Farm;Flowers;Follow-Up Studies;Genotype;Health;Health Personnel;Home;Homeostasis;Individual;Inflammatory;insight;interest;Knowledge;Laboratories;Life;life span;Link;lipid mediator;lipidomics;Lipids;Marijuana;marijuana legalization;marijuana use;marijuana user;Measures;Medical;Medical Marijuana;Medicine;mental function;Metabolic;metabolic profile;Metabolism;metabolomics;Methods;Monitor;Outcome;Parkinson Disease;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacokinetic model;Physicians;Physicians' Offices;Physiological;Physiological Processes;Pilot Projects;Population;programs;Property;Proteomics;Publishing;Recreation;Reporting;repository;Research;Research Personnel;Research Project Grants;research study;Risk;Sampling;Sampling Studies;Services;Smoking;Study Subject;technology validation;Terpenes;Tetrahydrocannabinol;THC concentration;Tobacco use;trend;Uncertainty;vaporization

PROJECT_TITLE: Cannabis Research Analytics Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cost Effectiveness Research;Lung;Lung Cancer;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Relevance Based on our preliminary results, we propose to evaluate tissue-serum LuCa metabolomics and develop them into early-stage lung cancer contrast probes. The overarching goal is to develop a novel serum contrast probe able to reveal early lung cancer.

PI_NAMEs: FARRAR, CHRISTIAN T (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: American College of Radiology Imaging Network;biobank;biomarker identification;Cancer Detection;cancer diagnosis;candidate identification;Caring;Characteristics;Classification;Clinic;cost effective;cost effectiveness;Cost Effectiveness Analysis;Data;Detection;Development;Diagnostic;diagnostic biomarker;Disease;Early Diagnosis;Effectiveness;efficacy evaluation;efficacy validation;Epidermal Growth Factor Receptor;Gene Mutation;Goals;Health;high risk;Human;Image;imaging approach;imaging probe;Interdisciplinary Study;KRAS2 gene;Lead;Lesion;lung basal segment;lung cancer screening;Magnetic Resonance Spectroscopy;Malignant neoplasm of lung;mass spectrometric imaging;Mass Spectrum Analysis;Measures;meetings;Metabolic;metabolomics;Methodology;minimally invasive;mutational status;novel;novel strategies;Pathology;Patients;Populations at Risk;prognostic;Prognostic Marker;programmed cell death protein 1;protocol development;Quality of life;repository;Research;Sampling;Sensitivity and Specificity;Serum;Signal Transduction;Smoker;Specimen;Technology;Testing;Tissues

PROJECT_TITLE: Novel metabolomic contrast probes for human lung cancer characterization

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Congenital Structural Anomalies;Genetic Testing;Genetics;Infant Mortality;Neurodegenerative;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Newborn screening for a subset of diseases for which early treatment leads to a better patient quality of life is warranted in order to prevent the onset of irreversible symptoms. Our research is focused on developing technology for newborn screening of congenital diseases in neonates. A second phase is develop technology to improve the precision of newborn screening so as to reduce the number of false positives and associate family anxiety.

PI_NAMEs: GELB, MICHAEL H (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Acid Lipase;Adopted;Age of Onset;Anxiety;Area;assay development;Behavior;Biliary Atresia;Bilirubin;Biliverdine;Biological Assay;Biological Markers;Blood;Blood specimen;CD3 Antigens;Chemicals;Cholesterol Ester Storage Disease;Clinical Trials;Collaborations;Combined molybdoflavoprotein enzyme deficiency;cost;Creatine;Creatinine;Development;Disease;Dryness;Early Diagnosis;Early treatment;Enzymes;Evaluation;Family;follow-up;formylglycine;Foundations;Generations;Glucuronic Acids;Glycogen storage disease type II;Glycosaminoglycans;Goals;Grant;improved;interest;Laboratories;Life;Lysosomal Storage Diseases;Measurement;Measures;Menkes Kinky Hair Syndrome;Metachromatic Leukodystrophy;Methods;Mucopolysaccharidoses;multiplex assay;Neonatal Screening;neonate;Newborn Infant;Patients;Phase;Pilot Projects;prevent;prognostic;Proteins;Quality of life;Reagent;Research;Research Personnel;research study;Residual state;Retirement;Role;Sampling;screening;Severities;Severity of illness;Spottings;Sulfatases;Symptoms;T-Lymphocyte;tandem mass spectrometry;Technology;Testing;Washington;Wolman Disease;Work;Workload

PROJECT_TITLE: Development of Assays for Newborn Screening and for Post-Screening Evaluation of Disease Severity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-A(02)M]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Lung;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Esophageal cancer is a devastating disease with the majority of patients being diagnosed after the tumor has metastasized, leaving patients with the 5-year relative survival rate of only 5%. The proposed work seeks to better understand the underlying mechanisms of metastasis in esophageal carcinoma, as well as to target the identified pathway in pre-clinical models. Overall, in the long term, this study will introduce more effective and targeted treatments to patients with metastatic esophageal cancer, and potentially other deadly cancers with similar genetic and epigenetic properties.

PI_NAMEs: EFE, GIZEM  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: 3-Dimensional;Advisory Committees;Affect;anti-cancer research;Autocrine Communication;Award;base editing;Binding;Bromodomain;Cancer Etiology;cancer type;career;career development;Cell Line;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical;collaborative environment;Communication;CSF1R gene;Data;Development Plans;Diagnosis;Disease;DNA Binding;DNA Binding Domain;effective therapy;Epigenetic Process;Esophageal carcinoma;Esophageal Squamous Cell Carcinoma;Event;Faculty;Foundations;Future;gain of function;Genetic;Genetic Transcription;Genomics;Goals;Grant;Homologous Gene;Human;improved;In Vitro;in vivo;in vivo Model;Institution;Invaded;M cell;Macrophage;Macrophage Colony-Stimulating Factor;Malignant Epithelial Cell;Malignant neoplasm of esophagus;Malignant Neoplasms;Manuscripts;Mediating;Mediator;Medical center;Mentorship;metastatic esophageal;Metastatic Neoplasm to the Lung;migration;Missense Mutation;Modeling;Molecular Conformation;mortality;mouse model;Mus;mutant;Mutate;Mutation;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel therapeutic intervention;Oncogenic;Organoids;Outcome;Pathway interactions;Patients;pharmacologic;Positioning Attribute;Postdoctoral Fellow;Pre-Clinical Model;Primary Neoplasm;Prognosis;programs;Proliferating;Property;Reader;receptor;Recurrence;Resources;Role;Scientist;Signal Pathway;Signal Transduction;single cell ATAC-seq;skills;small hairpin RNA;small molecule;Squamous cell carcinoma;Survival Rate;tenure track;Testing;Therapeutic;Thinking;TP53 gene;Training;transcriptome sequencing;transcriptomics;tumor;Tumor Cell Invasion;tumor growth;Tumor Promotion;Tumor Suppressor Proteins;Tumor-associated macrophages;tumorigenesis;tumorigenic;Universities;Up-Regulation;Work;Writing

PROJECT_TITLE: Elucidation of mutant p53-medidated mechanisms in promoting metastatic esophageal cancer


NIH_SPENDING_CATS: Cannabidiol Research;Cannabinoid Research;Clinical Research;Complementary and Integrative Health;Data Science;Drug Abuse (NIDA only);Endocannabinoid System Research;Machine Learning and Artificial Intelligence;Natural Products;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse;Therapeutic Cannabinoid Research

PI_NAMEs: CALHOUN, VINCE D (contact)

PROJECT_TERMS: 2-arachidonylglycerol;Adolescent;age group;Biological;Blood;Brain;Canada;Cannabidiol;Cannabinoids;Cannabis;Clinical;Clinical Data;CNR1 gene;CNR2 gene;Collection;Computer software;dashboard;Data;Data Analyses;Data Collection;data harmonization;data sharing;deep learning;Development;District of Columbia;Electronics;Endocannabinoids;endogenous cannabinoid system;Equation;Funding;Future;Goals;Health;Hemp;Immune system;Industry;Informatics;Legal;life span;Ligands;lipid mediator;Machine Learning;marijuana legalization;Measurement;Measures;Mediating;Medical Marijuana;Mexico;Modeling;Moods;National Institute of Drug Abuse;Neurocognition;Neurocognitive;neuroimaging;North America;Outcome;Pilot Projects;Protocols documentation;Research;Services;substance use;Support System;Testing;Tetrahydrocannabinol;trend;United States;Work

PROJECT_TITLE: Data Harmonization and Analysis Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: FLAGSTAFF

ORG_NAME: NORTHERN ARIZONA UNIVERSITY

PHR: Project narrative Up to 80% of preterm infants experience feeding-related problems, often due to an inability to generate the suction necessary for the acquisition and transport of liquid, yet our understanding of the neuromotor mechanisms governing these behaviors is limited. By varying sensory input through pressure generation and milk viscosity (K99) as well as feeding on a biomimetic nipple (R00), I propose to determine the neuromuscular mechanisms that control feeding in preterm infants. These results will serve as a foundation for the development of evidence-based interventions to ensure that all children have the chance to live healthy and productive lives.

PI_NAMEs: MAYERL, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TITLE: The impact of biomimetic nipple on infant feeding function


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: EAST ORANGE

ORG_NAME: VA NEW JERSEY HEALTH CARE SYSTEM

ORG_STATE: NJ

PHR: Gulf War Veterans (GWVs) with Gulf War Illness (GWI) do not receive the care they should in the Veterans Affairs (VA). Our data show 70% of GWVs with Gulf War Illness (GWI) do not receive treatment recommendations for their GWI and 78% are NOT very satisfied with their care. We must improve the quality of care GWVs receive. VA and DoD have invested hundreds of millions of dollars to develop new treatments for GWVs, without effective delivery methods GWVs will not benefit. This study will be the first study to examine the best model of care to deliver treatments to GWVs with GWI. Determining the best model of care to translate research into practice is a key goal of the VA Gulf War Strategic Plan and a specific aim of this Request for Applications.

PI_NAMEs: MCANDREW, LISA MARIE (contact)

PROJECT_TERMS: Academy;Address;Advisory Committees;Analgesics;barrier to care;British;Caring;chronic pain;Clinic;Clinical Trials;collaborative care;Competence;Complex;Consolidated Framework for Implementation Research;Consultations;Data;disability;Education;effective therapy;effectiveness evaluation;effectiveness-implementation randomized trial;Electronics;Future;Geographic Locations;Goals;Guidelines;Gulf War;Gulf War veteran;Health;health care model;Health system;Hybrids;implementation outcomes;implementation study;improved;Information Dissemination;Injury;interest;Interview;Investments;Knowledge;Lead;Measures;medical specialties;Medicine;Mental Depression;Methods;Modeling;operation;Outcome;Pain;Parkinson Disease;Patient Self-Report;Patients;Persian Gulf Syndrome;Pharmacologic Substance;physical symptom;Primary Care;primary care patient;primary care provider;Problem Solving;Provider;Quality of Care;Randomized;Recommendation;relative effectiveness;Request for Applications;research to practice;Resources;satisfaction;Site;skills;Specialist;Strategic Planning;Symptoms;telehealth;Translating;Translational Research;United States Department of Veterans Affairs;War;Work

PROJECT_TITLE: Collaborative Specialty Care for Gulf War Illness

STUDY_SECTION: SPLD

STUDY_SECTION_NAME: Special Emphasis - Research on Gulf War Veterans' Illnesses[SPLD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Mental Health;Mental Illness;Natural Products;Pediatric;Psychosis;Substance Misuse;Therapeutic Cannabinoid Research

PI_NAMEs: HOPFER, CHRISTIAN J (contact)

PROJECT_TERMS: Abstinence;Acute;Affect;affective disturbance;age group;anandamide;Anti-Anxiety Agents;Anxiety;Cannabidiol;Cannabinoids;Cannabis;cannabis administration;Cannabis policy;Cannabis retail;cannabis self-administration;Chronic;cognitive function;Data;Dissociation;Dose;drug reward;emerging adult;Exhibits;experience;Exposure to;Flowers;Goals;Harm Reduction;Hemp;High Prevalence;high risk;Individual;Intoxication;Investigation;Legal;marijuana use;marijuana use disorder;marijuana user;Mental Depression;Mental Health;mood symptom;Moods;novel;novel therapeutics;Outcome;Paranoia;Participant;Pharmaceutical Preparations;placebo group;Placebos;Plants;Plasma;psychotic;psychotic symptoms;Randomized;randomized placebo controlled study;recruit;Research;Research Design;response;Sales;Sampling;Self Administration;Supplementation;Symptoms;Testing;THC exposure;United States;United States Food and Drug Administration;Withdrawal;young adult

PROJECT_TITLE: A Randomized, Placebo Controlled Study of Cannabidiol in Young Adult Cannabis Users


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Influenza;Pediatric;Pneumonia and Influenza;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: DENVER

ORG_NAME: DENVER HEALTH AND HOSPITAL AUTHORITY

PHR: Project Narrative While the COVID‐19 pandemic has highlighted health disparities, Black children have unduly suffered and died from seasonal influenza for decades. Through sustained partnership with Black community stakeholders, novel community‐engaged research methods, and an innovative intervention approach, this proposal will explore, develop, and test a Digital Storytelling intervention to reduce influenza vaccination disparities in Black children aged 6 months to 5 years. This project will advance our understanding of engagement methods and interventions that improve health equity and serve as a model for future work to address vaccination disparities, ensuring all individuals have the chance to fulfill their potential free of preventable diseases.

PI_NAMEs: WILLIAMS, JOSHUA TYLER BONNEMA (contact)

PROGRAM_OFFICER_NAME: KING, TRACY

PROJECT_TERMS: 2 year old;Address;Adult;African American;aged;Agreement;Area;Black race;Caregivers;Cessation of life;Child;Child Development;Child Health;Child health equity;Childhood;Clinic;Clinical;college;Colorado;Communities;community engaged research;community engagement;Contracts;COVID-19;COVID-19 pandemic;design;digital;Disadvantaged;Disease;Disparity;Educational workshop;Effectiveness;Effectiveness of Interventions;Ensure;Environment;Equity;Ethnic Origin;experience;Family;Fellowship;Funding;Future;Goals;Grant;Health;health care availability;Health Disparities Research;health disparity;health equity;health equity promotion;health illiteracy;Health Promotion;Health Services Research;Hearing;Hospitalization;Human;Human Papilloma Virus Vaccination;Hypertension;hypertension control;Image;implementation science;improved;Individual;Influenza;Influenza prevention;Influenza vaccination;influenza virus vaccine;innovation;Intervention;Interview;Koreans;Learning;learning community;meetings;member;Mentors;Mentorship;Methods;Minority;minority communities;Mission;Modeling;Neighborhoods;novel;Outcome;pandemic influenza;Paper;Parents;Patient Self-Report;pediatrician;Perception;personal narratives;Pilot Projects;Positioning Attribute;post intervention;pragmatic trial;preference;Qualitative Methods;Race;Randomized;Recommendation;Recording of previous events;Research;Research Methodology;Research Personnel;Research Training;Risk;safety net;Schedule;seasonal influenza;Seasons;Structure;success;System;Testing;Text;therapy design;Training;Translations;Transportation;Trust;Universities;unvaccinated;Vaccinated;Vaccination;vaccine acceptance;vaccine hesitancy;vaccine trial;Vaccines;Voice;Woman;Work

PROJECT_TITLE: Digital Storytelling to Reduce Pediatric Influenza Vaccination Disparities: A Pilot Pragmatic Trial

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


NIH_SPENDING_CATS: Behavioral and Social Science;Cannabidiol Research;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Drug Abuse (NIDA only);Endocannabinoid System Research;Natural Products;Substance Misuse;Therapeutic Cannabinoid Research

PI_NAMEs: SCHACHT, JOSEPH P. (contact)

PROJECT_TERMS: Achievement;Acute;Adult;Anxiety;Biological Markers;Blood;Blood specimen;Cannabidiol;Cannabinoids;Cannabis;cannabis administration;cannabis craving;cannabis cue;CNR1 gene;CNR2 gene;Consumption;craving;cue reactivity;Data;Dose;drug reward;Endocannabinoids;exogenous cannabinoid;Flowers;Harm Reduction;Ingestion;Intoxication;Laboratories;marijuana legalization;marijuana use;marijuana user;Marketing;Mediating;medication compliance;negative affect;novel;Outcome;Paranoia;Participant;Pharmaceutical Preparations;Pharmacology;Placebo Control;Placebos;Plants;Preparation;Protocols documentation;Quasi-experiment;Randomized;randomized placebo controlled study;Randomized, Controlled Trials;Recreation;recruit;Research;response;Risk;Self Administration;Symptoms;Testing;Tetrahydrocannabinol;THC concentration;Therapeutic;United States

PROJECT_TITLE: Cannabidiol and Cannabis Concentrate Users: A Randomized, Placebo Controlled Study


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Natural Products;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Novel systemic treatments are urgently needed for hepatocellular adenocarcinoma (HCC) because patients with advanced HCC have a grave prognosis. The current project offers innovative solutions that overcome resistance to chemotherapy. This strategy, when successfully introduced into the clinic, will fulfill the unmet clinical need for improving the survival and quality of life of HCC patients.

PI_NAMEs: CHOW, DIANA S-L.;LI, CHUN  (contact);YANG, PEIYING

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Adenocarcinoma;Animal Model;Apoptosis;BAY 54-9085;Biodistribution;Biological Assay;Biological Markers;c-myc Genes;cancer cell;cancer stem cell;cancer type;Canis familiaris;Chemistry;chemotherapeutic agent;chemotherapy;Clinic;Clinical;Clinical Pathways;clinical risk;clinical translation;clinically relevant;Combined Modality Therapy;Complement Activation;cyclopamine;cytotoxic;density;Development;Distant;Dose;drug development;drug efficacy;Drug Kinetics;Drug Packaging;drug release profile;Drug resistance;effective therapy;Endotoxins;epithelial to mesenchymal transition;Extracellular Matrix;Fibrosis;Formulation;Future;Gastrointestinal Neoplasms;Genes;Goals;Hemolysis;improved;inhibitor;innovation;insight;Liquid Chromatography;Liver;liver cancer model;Liver Cirrhosis;Malignant neoplasm of pancreas;Malignant Neoplasms;manufacture;Mass Spectrum Analysis;Messenger RNA;Micelles;Mitosis;Monitor;Multi-Drug Resistance;Mus;Mutation;neglect;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;Oncogenes;Organ;Outcome;Paclitaxel;patient derived xenograft model;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Plasma;Platelet aggregation;Play;Polymers;Pre-Clinical Model;Preparation;Prevalence;Prevention;Preventive;Primary carcinoma of the liver cells;Prognosis;Proliferating;Quality of life;Rattus;Recurrence;Reproducibility;Research Contracts;Resistance;response;Risk;Rodent;Role;scale up;self-renewal;Site;smoothened signaling pathway;spheroids;stem cell biomarkers;stemness;success;System;Systemic Therapy;systemic toxicity;Technology;Therapeutic;Toxic effect;Transgenic Mice;Translating;Transplantation;tumor;tumor initiation;Tumor Stem Cells;Tyrosine Kinase Inhibitor;Up-Regulation;Work;zeta potential

PROJECT_TITLE: Pre-IND Development of Polymeric Micelles with Dual Drug Payloads for HCC Therapy


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Diabetes;Digestive Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Gastroparesis is a common and serious disorder with complicated pathophysiology and limited treatment options. In this project we will develop and use advanced magnetic resonance imaging (MRI) technologies to investigate mechanisms of gastroparesis involving various gastric motor functions in both healthy and diabetic animals and humans. The success of this project will lead to an improved understanding of gastroparesis and facilitate development of effective therapies for gastroparesis.

PI_NAMEs: CHEN, JIANDE  (contact);WILEY, JOHN W

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Address;Anatomy;Animals;Antral;Back;Bilateral;Clinical;Complex;Complication;Complications of Diabetes Mellitus;Computer Models;Computer Simulation;Computer-Assisted Image Processing;contrast enhanced;Development;Diabetes Mellitus;diabetic;diabetic gastroparesis;diabetic patient;diabetic rat;Disease;Duodenum;effective therapy;Event;Functional disorder;Fundus;Gastric Emptying;Gastroparesis;Health;Human;Hydrostatic Pressure;Image;image processing;Imaging technology;Impairment;improved;in vivo;Individual;Intestines;Investigation;Liquid substance;Magnetic Resonance Imaging;Modeling;Motility;Motor;Nerve;new technology;novel;novel strategies;Patients;Play;pressure;Prevalence;Process;Pylorus;Rattus;Regulation;Relaxation;responders and non-responders;Rodent;Rodent Model;Role;side effect;Solid;Stomach;Streptozocin;success;symptomatic improvement;Symptoms;Technology;Testing;Vagotomy;Vagus nerve structure

PROJECT_TITLE: Use of novel MRI technology to study pathophysiology diabetic gastroparesis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: DAVIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative Opioids cause many changes in the brain, some of which underlie substance use disorder, but most of which merely reflect exposure to drug, including benefits such as pain relief. Identifying the neural substrates underlying the pathologic side effects of opioid use, and disentangling them from the beneficial effects of opioid drugs in particular, will be critical for intervening in the opioid crisis.

PI_NAMEs: WHISTLER, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Abstinence;Acute;addiction;Agonist;Analgesics;Animals;Arrestins;Behavior;Behavioral;Biology;Brain;Cells;Characteristics;Clinical;Cognitive;Color;Data;Decision Making;Dependence;Derivation procedure;Diagnosis;Dissociation;Distress;Dopamine;Dopamine D2 Receptor;dopaminergic neuron;Dose;Down-Regulation;drug abstinence;Drug abuse;Drug Exposure;Drug Modelings;drug withdrawal;Endocytosis;Endorphins;Engineering;Enkephalins;Equilibrium;Essential Drugs;experimental study;Exposure to;Failure;flexibility;G-Protein-Coupled Receptors;GABA Receptor;gamma-Aminobutyric Acid;Genotype;Goals;GTP-Binding Proteins;Human;Impairment;Knock-in Mouse;Lateral;Ligands;Link;Medial;Modeling;Molecular;Monitor;Morphine;Morphine Dependence;mu opioid receptors;Mus;mutant;Naloxone;neural;neuroadaptation;neuromechanism;Neurons;novel;Nucleus Accumbens;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid use;Pain;pain relief;Pathologic;Pathology;Patients;Pharmaceutical Preparations;Pharmacology;Phenotype;Physical Dependence;Positioning Attribute;Pre-Clinical Model;pre-clinical research;preclinical study;Prefrontal Cortex;prevent;Probability;Property;protein activation;receptor;recruit;Recycling;Regimen;Relapse;Research;response;Rewards;Risk;Role;Self Administration;sensor;side effect;Signal Transduction;Signaling Protein;Study models;Substance Use Disorder;Synapses;Time;Titrations;tool;Ventral Tegmental Area;Weaning;Wild Type Mouse;Withdrawal;Work

PROJECT_TITLE: Signaling balance and opioid dependence

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Lung;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: DURHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Chlorine and phosgene gases were used in chemical warfare and pose a grave threat to lung health. We proposed to investigate which cells of the lung are sensitive to damage by these chemicals, and study how these cells can be protected to heal the lung.

PI_NAMEs: ACHANTA, SATYANARAYANA ;JORDT, SVEN-ERIC  (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Accidents;adiponectin;Affect;airway epithelium;Alveolar;Alveolar Cell;alveolar epithelium;Alveolus;Amyloid Proteins;Anatomy;Anesthesia procedures;Animals;Antibodies;Basal Cell;Blood capillaries;Cell Communication;Cell Survival;cell type;Cells;cellular imaging;Chemical Warfare;Chemicals;Chlorine;Comparative Study;design;Development;Endothelial Cells;endothelial regeneration;Endothelium;Epithelial Cells;epithelial repair;Epithelium;Exposure to;Family suidae;Fibrinogen;Functional disorder;Gases;healing;Hour;Human;improved;Industrial Accidents;Inhalation;Injury;insight;Location;Long-Term Effects;Lung;lung health;lung injury;lung repair;Maintenance;Maps;Mechanical Stress;Mechanical ventilation;Methods;Microscopy;Modeling;Molecular;Monitor;Mouse Strains;Mus;Natural History;novel;Occupational;Oxygen;Pathway Analysis;Pattern Recognition;Phosgene;Population;porcine model;Positioning Attribute;Prone Position;Proteins;Protocols documentation;Recovery;Reporter;respiratory health;Risk;Rodent;Rodent Model;Serum;single cell sequencing;Slice;standard of care;Stretching;Structure;Submucosa;Supine Position;Terrorism;Thick;tissue regeneration;Tissues;Transitional Cell;Transportation;Vascular Cell Adhesion Molecule-1;vascular injury;ventilation;Ventilator;Visualization

PROJECT_TITLE: Pulmonary cell fate and lung repair in rodent and porcine models of chlorine and phosgene inhalation injuries


NIH_SPENDING_CATS: Genetics

ORG_DEPT: PHARMACOLOGY

PHR: Broken DNA is particularly problematic when it is present during cell division. We have developed a distinctive model to understand how cells prevent negative outcomes arising from broken DNA during cell division. Given that persistent broken DNA contributes to metastatic cancer, that FancD2 is linked to the childhood disease Fanconi Anemia, and the interest in Pol Theta and CRL4CDT2 as a promising cancer therapy targets, our work promises a significant impact on human health.

PI_NAMEs: FOX, DONALD T. (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Amaze;Area;Behavior;Biochemical;Biochemistry;Biological;Biological Models;Biology;Cell Cycle;Cell Death;Cell division;Cell Nucleus;Cells;Centromere;Childhood;Chromosomal Breaks;Chromosome Condensation;Chromosome Segregation;Chromosome Structures;Chromosomes;Complex;condensin;Data;Defect;Dependence;Detection;Development;Disease;Disseminated Malignant Neoplasm;DNA;DNA damage checkpoint;DNA Double Strand Break;DNA Repair;DNA Repair Gene;DNA Repair Pathway;DNA Structure;DNA-Directed DNA Polymerase;Drosophila genus;Elasticity;Exhibits;Face;FANCD2 protein;Fanconi's Anemia;Genetic;Genetic Epistasis;Genetic Screening;Genome;Genomic Instability;Goals;Health;Human;Image;Immunity;in vivo;innovation;insight;interest;Interphase;Interphase Cell;Laboratories;Left;Link;Malignant Neoplasms;Mammalian Cell;Mediating;micronucleus;Mitosis;Mitotic;Mitotic Chromosome;Modeling;Molecular;Monoubiquitination;Nature;Outcome;Pathway interactions;Positioning Attribute;prevent;Process;Property;Proteins;Proteomics;recruit;Rectum;Recurrence;Regulation;repaired;response;Role;scaffold;segregation;Signal Pathway;Site;Source;Structure;System;targeted cancer therapy;Testing;Tissues;tumor progression;ubiquitin ligase;Wing;Work

PROJECT_TITLE: Broken chromosome segregation during mitosis: a Drosophila model

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Drug Abuse (NIDA only);Endocannabinoid System Research;Natural Products;Neurodegenerative;Neurosciences;Pain Research;Sleep Research;Substance Misuse;Therapeutic Cannabinoid Research

PI_NAMEs: BRYAN, ANGELA  (contact)

PROJECT_TERMS: 2-arachidonylglycerol;Acute;Affect;age related changes;Age-associated memory impairment;Aging;aging population;Alzheimer's Disease;anandamide;Animals;Anti-Inflammatory Agents;Anxiety;Area;Benefits and Risks;Biological;Biological Markers;Blood;Cannabidiol;Cannabinoids;Cannabis;chronic pain management;Cognition;Cognitive;cognitive function;Collection;Colorado;Coupled;Data;design;Dizziness;Dose;Drowsiness;economic cost;Endocannabinoids;endogenous cannabinoid system;epidemiologic data;equilibration disorder;Equilibrium;fall risk;Goals;Health;Hemp;human old age (65+);IL6 gene;Impaired cognition;improvement on sleep;Inflammation;Inflammatory;interest;Laboratories;Link;marijuana use;marijuana user;Mediating;Memory;Mental Depression;mild cognitive impairment;Morbidity - disease rate;mortality;motor control;negative affect;Nerve Degeneration;neuroprotection;older adult;Older Population;Outcome;Pain;Pain management;Pain Measurement;Placebo Effect;Placebos;Play;Polypharmacy;Prevalence;Property;Public Health;Randomized;randomized placebo controlled study;Randomized, Controlled Trials;Research;Research Priority;Risk;Role;side effect;Sleep;Sleep Disorders;sleep quality;sleep quantity;socioeconomics;Surveys;Tetrahydrocannabinol;TNF gene;verbal

PROJECT_TITLE: Cannabidiol and Older Adult Cannabis Users: A Randomized, Placebo Controlled Study


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stomach Cancer

PHR: NARRATIVE Gastric cancer develops within a carcinogenic cascade from pre-cancerous metaplasia to dysplasia and adenocarcinoma. While the pre-cancerous metaplasia is possibly reversible, a key cell population which is responsible for mucosal recovery or neoplastic progression is to be defined. In this study, we will define mechanisms that control the cell lineage conversion of reparative SPEM cells, which are a major cell component of dysplasia, towards incomplete IM and more cancerous cell lineages.

PI_NAMEs: CHOI, EUNYOUNG  (contact);GOLDENRING, JAMES RICHARD

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Address;Adenocarcinoma;Alleles;ATAC-seq;Automobile Driving;cancer cell;Cancer Etiology;cancer stem cell;Cancerous;carcinogenicity;Cell Lineage;cell type;Cells;Cellular Structures;Cessation of life;Chief Cell;Chronic;Clonal Evolution;CRISPR/Cas technology;Derivation procedure;Dysplasia;Epigenetic Process;epigenome;Evolution;Gastric Adenocarcinoma;gastric cancer prevention;gastric carcinogenesis;gastric corpus;Gastric Intraepithelial Neoplasia;Gastric Parietal Cells;Gene Activation;Gene Mutation;Genes;Genetic;Genetic Transcription;Goals;Heterogeneity;high risk;Human;In Vitro;in vivo;Inflammation;Injury;Intestinal Intraepithelial Neoplasia;Intestinal Metaplasia;Lesion;Malignant Neoplasms;malignant stomach neoplasm;Metaplasia;Modeling;Molecular;mouse model;Mucous Membrane;Mus;Mutation;neoplastic;Neoplastic Processes;novel;Oncogenes;Oncogenic;Organoids;Pathway interactions;Patients;Phase;Population;precursor cell;premalignant;Process;Production;programs;promoter;Property;Recovery;Reporter;response;response to injury;Role;Sampling;Signal Pathway;single-cell RNA sequencing;Source;spasmolytic polypeptide;stem cells;Stomach;Therapeutic Intervention;Time;transcriptome;transdifferentiation;Transgenic Mice;tumor progression

PROJECT_TITLE: Cell plasticity in the origin of gastric carcinogenesis


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Despite more than half of all cancer patients receiving radiotherapy as part of their treatment, the complex interactions between radiation and the immune system are poorly understood. Our Center will work to improve understanding of radiation effects on the immune system (tested first in pancreas and cervical cancer) and use that knowledge to propose new radiation treatment combinations to improve the outcomes of patients with advanced cancer. We will bring together a diverse group of experts from many fields, while teaching the next generation of researchers.

PI_NAMEs: ROBINSON, CLIFFORD GRANT;SCHWARZ, JULIE KRISTINA (contact)

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;Aftercare;anti-tumor immune response;Bioinformatics;Biological;Biopsy;Blood;Cancer Biology;Cancer Patient;career development;cell type;Cells;chemokine;chemoradiation;Clinical;Clinical Data;clinical translation;Collaborations;Collection;Combined Modality Therapy;Communication;Complex;Data;data management;Data Science;data sharing;Dendritic Cells;design;Development;DNA Damage;dosimetry;druggable target;Educational Materials;Educational process of instructing;Environment;Equilibrium;experimental study;Faculty;functional genomics;Funding;Future;Gene Expression;Genomic approach;Genomics;Goals;Grant;Image;Immune;Immune system;immunogenic cell death;immunogenicity;Immunosuppression;improved;improved outcome;In Vitro;in vivo;Infiltration;Informatics;Institution;interdisciplinary collaboration;interest;Knowledge;Language;Locally Advanced Malignant Neoplasm;Macrophage;Major Histocompatibility Complex;Malignant neoplasm of cervix uteri;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical;member;Metabolism;Modality;Modeling;Molecular;molecular dynamics;multidisciplinary;Myelogenous;neoantigens;neoplastic cell;new technology;next generation;novel drug combination;Oncology;Outcome;patient population;Patient-Focused Outcomes;Patients;permissiveness;Phenotype;Physics;Pilot Projects;Positioning Attribute;programs;Proliferating;prospective;Proteomics;Radiation;radiation effect;Radiation Oncologist;Radiation Oncology;Radiation therapy;Radiometry;recruit;Relapse;repaired;Research;Research Design;Research Personnel;Research Project Grants;Resistance;Resource Development;Resource Sharing;Resources;Sampling;Signal Transduction;Site;Specimen;standard of care;temporal measurement;Testing;Time;Tissues;Training;Training Programs;translational genomics;translational study;treatment effect;tumor;Tumor Antigens;Tumor Immunity;tumor immunology;tumor metabolism;tumor microenvironment;tumor-immune system interactions;United States National Institutes of Health;Universities;Vision;Washington;Work

PROJECT_TITLE: Washington University (WU) ROBIN Center: MicroEnvironment and Tumor Effects Of Radiotherapy (METEOR)


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Pulmonary Fibrosis;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Distinct epithelial stem/progenitor cell pools and/or their mesenchymal niches repopulate injured tissue depending on the extent and type of injury, and the outcomes of regeneration or fibrosis in response to severe alveolar epithelial injury is dependent in part on the dynamics of cell competition between these cell populations. In tissues harboring a mosaic imbalance in cMyc or Yap protein levels, cells with higher cMyc or nuclear Yap levels become super-competitors and expand at the expense of cells with lower levels, by eliminating them. This grant proposal seeks to manipulate the underlying mechanisms of cell competition to help prevent and treat IPF and ARDS.

PI_NAMEs: DE LANGHE, STIJN PIET JOHAN (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 2019-nCoV;ACE2;Acute;Acute Respiratory Distress Syndrome;Age;AGTR2 gene;airway epithelium;Alveolar;alveolar epithelium;Alveolus;Applications Grants;c-myc Genes;Cell Proliferation;Cells;Cessation of life;Chronic;Collagen;comorbidity;Complication;coronavirus pandemic;COVID-19;COVID-19 pandemic;COVID-19 susceptibility;Data;Death Rate;Deposition;Diabetes Mellitus;Diagnosis;Disease;Epithelial Cells;epithelial injury;epithelial stem cell;Extracellular Matrix;Failure;Fibroblasts;Fibrosis;Genetic;Histologic;Hospital Mortality;Hypertension;idiopathic pulmonary fibrosis;Individual;injured;Injury;Interstitial Lung Diseases;Lesion;male;Mesenchymal;Middle East Respiratory Syndrome;mosaic;Myofibroblast;Natural regeneration;Nuclear;Outcome;Pathogenesis;Patients;Phase;Population;post SARS-CoV-2 infection;prevent;Proteins;Pulmonary Fibrosis;pulmonary function;receptor;repaired;replacement tissue;respiratory;Respiratory Failure;response;Risk Factors;SARS-CoV-2 infection;Severe Acute Respiratory Syndrome;severe COVID-19;sex;stem cell population;stem cells;Structure;Structure of parenchyma of lung;Syndrome;Tissues;Viral Respiratory Tract Infection

PROJECT_TITLE: Cell competition in pulmonary fibrosis and ARDS


NIH_SPENDING_CATS: Cancer;Radiation Oncology

PI_NAMEs: ROBINSON, CLIFFORD GRANT (contact)

PROJECT_TERMS: Adoption;Awareness;Basic Science;Biological;Clinical Sciences;Collaborations;Communication;Communication Tools;Data;data management;Development;digital;early phase clinical trial;Ensure;Environment;Improve Access;improved;industry partner;Malignant neoplasm of cervix uteri;Malignant neoplasm of pancreas;meetings;Modeling;Molecular;Monitor;multidisciplinary;Pathway interactions;Pilot Projects;Process;Radiation therapy;Research Project Grants;Resource Sharing;Resources;response;Science;Specimen;Structure;success;synergism;Technology;tool;Training;Translations;tumor;tumor microenvironment;Universities;University resources;Washington

PROJECT_TITLE: METEOR Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Racial and Ethnic Minority Health Research

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE The goal of this proposal is to increase patient activation and facilitate early integration of palliative care among English- and Spanish-speaking Hispanic/Latino patients with metastatic cancer. Using a mixed-methods approach, patient and provider focus groups and usability testing will inform the development and cultural adaptation of a patient activation intervention that is individualized using EHR-integrated symptom monitoring. A pilot randomized controlled trial will evaluate acceptability and preliminary effects of patient activation intervention on proximal outcomes in the early phases of palliative care introduction and referral (e.g., health- related quality of life, patient-provider communication, shared decision-making, beliefs/attitudes regarding palliative care).

PI_NAMEs: MORENO, PATRICIA INGRID (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Admission activity;advanced directive;aggressive therapy;American Society of Clinical Oncology;Attitude;Belief;Biological Models;Cancer Patient;care providers;Caring;Client satisfaction;Clinical Trials;Communication;Comprehensive Cancer Center;Confusion;culturally appropriate intervention;design;Development;Diagnosis;Disease;Disparity;Disseminated Malignant Neoplasm;Documentation;effectiveness-implementation RCT;effectiveness/implementation hybrid;empowerment;end of life;Enrollment;Ethnic Origin;experience;Family;Focus Groups;Future;Goals;health related quality of life;Health system;Healthcare Systems;Hispanic;Hispanic Populations;hospice environment;hospice utilization;Hospitals;improved;improved outcome;information gathering;innovation;Intervention;intervention effect;Language;Latino;Latino Population;Learning;low health literacy;Methodology;Methods;Modeling;Monitor;Not Hispanic or Latino;novel;Oncology;Outcome;Palliative Care;Participant;Patient Care;patient population;Patient-Centered Care;patient-clinician communication;Patients;perceived discrimination;Phase;Physicians;Positioning Attribute;Process;Provider;psychoeducation;Race;Randomized, Controlled Trials;Readiness;Recommendation;recruit;reduce symptoms;Research;Resources;satisfaction;shared decision making;skills;Socioeconomic Status;Spanish/English;standard of care;Standardization;Symptom Burden;symptom management;Symptoms;System;Testing;therapy development;Training;Trust;Universities;usability;web platform

PROJECT_TITLE: Patient Activation and Palliative Care among Hispanics/Latinos with Metastatic Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases;Women's Health Research

PROJECT_TERMS: Adjuvant Chemotherapy;advanced pancreatic cancer;Basic Science;biomarker identification;Biopsy;Cells;chemoradiation;chemotherapy;Cisplatin;Clinical;Clinical Data;cohort;Collaborations;Collection;Combined Modality Therapy;Complex;Coupled;curative treatments;Cytotoxic Chemotherapy;Data;Data Collection;Dendritic Cells;design;Development;Disease;Disease Outcome;Dose;early phase trial;Excision;External Beam Radiation Therapy;Failure;Foundations;Fractionation;Future;Generations;High-Dose Rate Brachytherapy;Image;image guided;Immune system;Immunotherapy;improved;improved outcome;Infrastructure;irradiation;Localized Disease;Locally Advanced Malignant Neoplasm;Macrophage;Malignant neoplasm of cervix uteri;Malignant neoplasm of pancreas;Malignant Neoplasms;Modality;Modeling;Molecular;multimodality;Neoadjuvant Therapy;Operative Surgical Procedures;Outcome;Paint;patient population;Patients;Pelvis;Pilot Projects;Prognosis;prospective;Radiation;Radiation Dose Unit;radiation effect;radiation resistance;Radiation therapy;Radiobiology;Recurrence;Recurrent disease;Registries;Relapse;Research Project Grants;Resistance;Resource Sharing;Resources;response;Risk;Role;Sampling;Solid Neoplasm;Specimen;standard of care;Structure;success;System;T-Lymphocyte;Testing;therapy development;therapy resistant;Time;trial design;tumor;Tumor Immunity;tumor microenvironment;Tumor Promotion;Universities;Washington

PROJECT_TITLE: METEOR-Comprehensive Radiobiology Assessment TRial (METEOR-CRATR)


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: PALM CITY

ORG_NAME: INTERNTL NARCOTICS RESEARCH CONF, INC.

PHR: Narrative Research into narcotics and addiction is moving rapidly with groundbreaking new techniques in neuroscience and in the structural biology of receptors. The International Narcotics Research Conference (INRC) meets each year and is the premier organization in the world for presentation of this important information. The proposed application is relevant to human health and the mission of NIDA since it is designed to disseminate, coordinate, and provide basic scientific and clinical knowledge that will pave the way to improved management of addictive diseases.

PI_NAMEs: TOLL, LAWRENCE R (contact)

PROJECT_TERMS: addiction;Applications Grants;Area;Award;Basic Science;Bathing;Biology;Canada;career;career development;Chicago;Clinical;college;Communities;cost;Data;Dedications;Dependence;design;Disabled Persons;Disease;Drug abuse;Drug Addiction;drug discovery;endogenous opioids;England;Epidemic;Equipment;ethnic minority;Expenditure;Financial Support;France;Funding;Future;Future Generations;graduate student;Grant;Health;Human;Image;improved;Individual;innovation;interest;International;Italy;Japan;Joints;Knowledge;Leadership;meetings;Michigan;Minority;Mission;Molecular;molecular modeling;Narcotics;National Institute of Drug Abuse;Neurosciences;Neurotransmitters;New York;North America;novel;opiate tolerance;Opioid;opioid abuse;opioid epidemic;Opioid Receptor;outreach;Pain;Pamphlets;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;Positioning Attribute;Postdoctoral Fellow;posters;racial minority;receptor;Request for Applications;Research;Research Personnel;Running;Science;Scientist;Signal Transduction;social media;Spain;structural biology;symposium;System;Techniques;Translations;Travel;Universities;Update;web site;Woman;Work

PROJECT_TITLE: 51st to 55th ANNUAL INTERNATIONAL NARCOTICS RESEARCHCONFERENCES


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurofibromatosis;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: NF2 is a disease in which patients develop tumors originating from cells of the nervous system. These cells, as with virtually all cancer cells, are characterized by the breakdown of mechanisms that in normal cells ensure proliferation only under appropriate conditions. Our goals are to identify these mechanisms and the proteins involved so that these can be targeted therapeutically.

PI_NAMEs: KISSIL, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Acceleration;Acetylation;Acoustic Nerve;Animal Model;Antineoplastic Agents;ATAC-seq;autosome;Binding;Bromodomain;cancer cell;cancer type;Cell Differentiation process;Cell Proliferation;Cells;ChIP-seq;Clinical Trials;Code;Contact Inhibition;Data;Development;Disease;Down-Regulation;Ensure;Ependymoma;Epigenetic Process;epigenomics;Family;Frequencies;Genes;Genetic Transcription;Genomics;Germ-Line Mutation;Goals;Growth;Hereditary Disease;Histone Acetylation;Histones;Impairment;in vivo;Inherited;inhibitor;interest;Loss of Heterozygosity;Lysine;Malignant Neoplasms;Mediating;meningioma;Mesothelioma;Modality;Molecular;Monomeric GTP-Binding Proteins;Mutate;Mutation;neoplastic cell;Nervous System;Nervous System Neoplasms;Neurilemmoma;Neurofibromatoses;Neurofibromatosis 2;Neurofibromin 2;Normal Cell;Output;Pathway interactions;Patients;Pharmaceutical Preparations;Phase I Clinical Trials;Play;prevent;programs;Proliferating;protein function;Proteins;ras Proteins;Reader;Receptor Protein-Tyrosine Kinases;Regulation;research clinical testing;Resolution;Role;Schwann Cells;Signal Pathway;Signal Transduction Pathway;small molecule;small molecule inhibitor;synergism;targeted treatment;Technology;Tertiary Protein Structure;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;Transcriptional Regulation;transcriptome sequencing;Translating;tumor;tumor growth;Tumor Suppressor Genes;tumorigenesis;virtual

PROJECT_TITLE: Elucidating the epigenetic landscape of neurofibromatosis and development of therapeutic targets

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cancer Genomics;Cervical Cancer;Clinical Research;Genetics;Human Genome;Immunotherapy;Radiation Oncology;Women's Health Research

PI_NAMEs: SCHWARZ, JULIE KRISTINA (contact)

PROJECT_TERMS: Address;Antibodies;Bioinformatics;biological specimen archives;Biology;Biopsy;Cancer Etiology;CD8-Positive T-Lymphocytes;Cell Count;Cell Physiology;cell type;Cells;Cervix Neoplasms;chemoradiation;Chronic;Cisplatin;Classification;clinically relevant;Coculture Techniques;Combined Modality Therapy;Communication;Data;Data Analyses;Dependence;design;Development;Exhibits;experimental study;Failure;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;functional genomics;Gene Expression;Genetic Transcription;Genetically Engineered Mouse;Glucose;glucose uptake;Glycolysis;Goals;Human;human data;human model;human papilloma virus oncogene;Human Papillomavirus;Image;imaging approach;Immune;immune checkpoint blockade;Immunocompetent;improved;improved outcome;Infection;Inflammation;Inflammatory;inhibitor;innovation;Macrophage;Malignant neoplasm of cervix uteri;Mediating;Mesenchymal;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Methods;mitochondrial metabolism;Modeling;mouse model;Mus;neoplastic cell;novel;Organoids;Oxidation-Reduction;Patients;Pelvis;permissiveness;Pharmaceutical Preparations;Phenotype;Positron-Emission Tomography;preclinical study;predicting response;programs;prospective;Proteomics;Radiation;radiation effect;Radiation Oncology;radiation resistance;Radiation therapy;Radiation Tolerance;Radiation-Induced Change;Reactive Oxygen Species;Recurrent disease;Recurrent tumor;Relapse;Research Project Grants;Resistance;Sampling;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;SOD2 gene;standard of care;T-Lymphocyte;Testing;Therapeutic;Time;Tissue Model;Tracer;Training;transcriptome sequencing;tumor;Tumor Bank;Tumor Cell Biology;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Promotion;Tumor-associated macrophages;Universities;Up-Regulation;uptake;Washington;Work

PROJECT_TITLE: Research Project  Cervical Cancer


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: Connecting Veterans to meaningful employment is a goal of VA, which has long recognized the important relationship between work and health by providing vocational rehabilitation to Veterans with disabilities. Many Iraq and Afghanistan war Veterans have experienced polytrauma/traumatic brain injury (PT/TBI) and are unemployed and looking for work. Studies have shown that some individuals with PT/TBI have trouble finding or keeping jobs because of problems with headaches, concentration, memory, planning, and other symptoms resulting from the injury. Supported employment (SE) is an effective program that helps Veterans find work that is meaningful to them, and provides them with unlimited support and job coaching. The Veteran’s SE and treatment teams work together to develop strategies for success in the workplace. This study will provide SE services to Veterans with PT/TBI and measure their employment, health symptoms, and self-esteem over time, and how well the SE and PT/TBI teams work together.

PI_NAMEs: POGODA, TERRI K. (contact)

PROJECT_TERMS: Address;Afghanistan;care systems;Caring;Client;Clinic;Clinical;Cognitive;Collaborations;Compensation;Diagnosis;disability;Educational Materials;Effectiveness;Emotional;Employment;Ensure;Evaluation;evidence base;Evidence based practice;experience;Freedom;gaps in access;Goals;Headache;Health;Health Services;Health Services Accessibility;Healthcare;Impairment;implementation strategy;Improve Access;improved;Individual;Injury;innovation;interest;Intervention;intervention refinement;Interview;Iraq;Marketing;Measures;Medical center;Memory;Mental Health;Methods;Modeling;Multiple Trauma;Occupations;operation;Outcome;Perception;Personal Satisfaction;Physical Medicine;Physical Rehabilitation;Population;post intervention;preference;prevent;Program Evaluation;programs;Promoting Action on Research Implementation in Health Services framework;Provider;psychologic;psychosocial;Recommendation;rehabilitation service;Reporting;Research;Resources;self esteem;service member;Services;severe mental illness;Site;skills;social;Specialist;success;Supported Employment;Surveys;Symptoms;Therapeutic;Time;Traumatic Brain Injury;Unemployment;Veterans;Vocation;Vocational rehabilitation;War;Work;Workplace

PROJECT_TITLE: Improving Access to Supported Employment for Veterans with Polytrauma/Traumatic Brain Injury

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

PI_NAMEs: DENARDO, DAVID G (contact)

PROJECT_TERMS: Address;Animal Model;Antigens;Biology;Bone Marrow;cancer cell;cancer type;Cell Count;Cell Differentiation process;Cell Physiology;Cell Survival;Cells;Cellular Immunity;Cellular Metabolic Process;checkpoint therapy;chemotherapy;Clinical;Correlative Study;Cross Presentation;Data;Dendritic Cells;density;Development;Exclusion;Foundations;Functional disorder;Genetically Engineered Mouse;Heterogeneity;Human;human imaging;human tissue;Hypoxia;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immunity;Immunotherapy;Impairment;improved;Infiltration;Institution;Lead;Limes;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolic;metabolic imaging;metabolic profile;Metabolism;metabolomics;mouse model;Myeloid Cells;Myeloid-derived suppressor cells;Myelopoiesis;Natural Immunity;Nature;neoplastic cell;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Patients;Phenotype;Pre-Clinical Model;Primary Neoplasm;Productivity;Prognosis;Prospective cohort;Proteins;Publishing;radiation effect;Radiation Oncology;radiation response;Radiation therapy;Regulation;Reporting;Research Project Grants;response;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Stimulant;Stromal Cells;T cell infiltration;T cell response;T-Lymphocyte;targeted treatment;Testing;Tissue Banks;Tissue Engineering;Tissue Model;Tissues;Treatment Efficacy;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Tumor-Derived;Universities;Washington

PROJECT_TITLE: Research Project  Pancreatic Cancer


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Fentanyl Misuse and Addiction;Lung;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

ORG_CITY: CLEVELAND

ORG_DEPT: PEDIATRICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative This project seeks to further our understanding of how bolus intravenous doses of N-acetyl-L-cysteine (L-NAC) to elicit immediate and sustained reversal of the deleterious effects of fentanyl infusion on breathing, arterial blood-gas chemistry and alveolar gas-exchange in rats without affecting fentanyl-induced analgesia. L-NAC is a clinically approved drug and could quickly enter clinical trials to assess its efficacy in human subjects.

PI_NAMEs: LEWIS, STEPHEN JOHN (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Absence of pain sensation;Adult;Adverse effects;Affect;Alveolar;Analgesics;analog;Anesthesia procedures;Animal Experiments;Animals;antagonist;Apnea;Blood gas;Bolus Infusion;Breathing;carfentanil;cell preparation;Cells;Chemistry;Childhood;Clinical;Clinical effectiveness;Clinical Trials;Continuous Infusion;Continuous Intravenous Infusion;Cysteine;Cystine;discount;Dose;efficacy evaluation;Esters;Female;Fentanyl;Funding;Gases;Glutathione;Goat;Human;human subject;Hypoxemia;in vivo;indexing;Infusion procedures;Injections;Intravenous Bolus;intravenous injection;male;mecysteine;Mediating;Methamphetamine;Modification;Morphine;N-acetylcysteine lysinate;National Institute of Drug Abuse;novel;Operative Surgical Procedures;Opioid;opioid abuse;Opioid Analgesics;Opioid Antagonist;opioid epidemic;opioid overdose;Opioid Receptor;Oral Administration;Oral Ingestion;Outcome;Overdose;Oxygen;pain relief;Parents;Pathway interactions;Patients;pediatric patients;Peripheral;Pharmaceutical Preparations;preservation;prevent;Rattus;Reporting;Respiration;S-ethyl glutathione;S-Nitrosothiols;sedative;Serine;side effect;Signal Transduction;Sulfhydryl Compounds;Sulfur;Therapeutic;Toxic effect;United States National Institutes of Health;ventilation;Ventilatory Depression;Vertebral column

PROJECT_TITLE: Repurposing L-NAC to prevent fentanyl-induced respiratory depression

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Prostate Cancer;Urologic Diseases

ORG_CITY: NISKAYUNA

ORG_NAME: GE MEDICAL SYSTEMS INFORMATION TECHNOLOGIES, INC

PHR: PROJECT NARRATIVE GE Research, Memorial Sloan Kettering Cancer Center, and Stanford University propose to develop an ultra- efficient 4 MVA gradient driver using new silicon carbide technology that enables higher gradient performance and the accompanying tissue microstructure imaging in clinical whole-body MRI scanners with existing gradient coils, and first demonstrate its efficacy and clinical benefit on the diagnosis and grading of early-stage prostate cancer as a pilot application. This work will provide a widely adoptable pathway to upgrade the gradient performance of any clinical wide-bore whole-body MRI scanner with a higher power gradient driver without extensive and expensive facility electrical service and cooling modifications. Higher gradient performance enables new tissue microstructure imaging methods that provide improved sensitivity and specificity for cancer diagnosis, neuroimaging, and cardiac and vascular imaging in the clinic.

PI_NAMEs: AKIN, OGUZ ;FOO, THOMAS K (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Abnormal Cell;Address;Adopted;Adoption;Appearance;Architecture;Biomedical Engineering;Biopsy;Biopsy Specimen;Blood Vessels;Brain;Breast;cancer diagnosis;Cancer Etiology;Cancer Prognosis;Cardiac;Cause of Death;Cessation of life;Charge;Clinic;Clinical;clinical application;clinical diagnosis;clinical diagnostics;clinical efficacy;clinically significant;Complex;cost;Data;design;Detection;Diabetes Mellitus;Diagnosis;diagnostic tool;Diffusion;Diffusion Magnetic Resonance Imaging;digital;Disease;Electronics;Elements;Epithelium;Frequencies;Gleason Grade for Prostate Cancer;Glioma;Goals;Hemorrhage;Histopathology;Hospitals;Human;Image;Imaging Device;imaging modality;improved;Indolent;Industry;Infection;Infrastructure;Lesion;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Measures;Memorial Sloan-Kettering Cancer Center;men;Methods;Microscopic;Modeling;Modification;multidisciplinary;Musculoskeletal;neuroimaging;novel;oscillating gradient spin echo;Output;Pain;Pathway interactions;Patient risk;Patients;Pattern;Performance;Pilot Projects;pre-clinical;Procedures;Prostate;prostate biopsy;Prostatectomy;prototype;Recommendation;Relaxation;Research;Sampling;Sampling Errors;Semiconductors;Sensitivity and Specificity;Services;Signal Transduction;Silicon;silicon carbide;soft tissue;Specificity;standard of care;Structure;success;System;Techniques;Technology;Testing;Time;Tissue Sample;Tissues;tool;tumor;tumor heterogeneity;ultrasound;Universities;Work

PROJECT_TITLE: Enabling clinical tissue microstructure imaging as a diagnostic tool in wide-bore 3T MRI

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-J(03)M]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Disability Research;Mental Health;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke;Telehealth

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF UTAH

PHR: PROJECT NARRATIVE Affecting nearly 800,000 people in the US every year, stroke is a leading cause of long-term disability, and has serious consequences for stroke survivors and their carepartners. Our project uses a scientifically rigorous efficacy study to evaluate a remotely delivered dyadic (couples-based) positive psychology intervention to reduce emotional distress in stroke survivors and their carepartners. If successful, couples may be better emotionally equipped to cope with the sequelae of stroke, and have better rehabilitation outcomes and quality of life.

PI_NAMEs: TERRILL, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Activities of Daily Living;Address;Adoption;Affect;Age;Anxiety;anxiety symptoms;Behavior;Brain hemorrhage;Caregivers;caregiving;Caring;Clinical;Cognitive;Communication;community reintegration;comparison control;Conflict (Psychology);Control Groups;control trial;coping;Couples;depressive symptoms;design;disability;Distress;effectiveness trial;efficacy evaluation;efficacy study;efficacy testing;efficacy trial;Emotional;emotional distress;Enrollment;experience;follow-up;Fostering;Future;Goals;gratitude;Health;Healthcare Systems;implementation study;improved;Individual;Intervention;intervention effect;intimate behavior;Ischemic Stroke;Learning;Length;Life;Long term disability;Measures;Mediating;Mediator;member;Mental Depression;National Institute of Child Health and Human Development;novel;Outcome;Participant;Personal Satisfaction;Persons;physical impairment;Pilot Projects;post stroke;primary outcome;promote resilience;Psychology;Quality of life;Randomized;Rehabilitation Outcome;rehabilitation science;Rehabilitation therapy;remote delivery;Reporting;Research;resilience;Resources;Role;Sampling;secondary outcome;sex;Sex Differences;Site;Spouses;Standardization;Stress;Stroke;stroke intervention;stroke survivor;Subgroup;Survivors;symptomatic improvement;Symptoms;Target Populations;Testing;theories;Time;Treatment Efficacy;trial design;Waiting Lists;Work

PROJECT_TITLE: Testing efficacy of an intervention to promote Resilience in Stroke survivor-carepartner Dyads (ReStoreD)

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Radiation Oncology

PI_NAMEs: MAJOR, MICHAEL BENJAMIN (contact)

PROJECT_TERMS: Adherence;Aftercare;Atlases;Bioinformatics;Biological;Biological Assay;Biological Response Modifier Therapy;Blood specimen;cancer genomics;Cataloging;Cervix Neoplasms;chemoradiation;Clinical;Collaborations;Comprehensive Cancer Center;Computer Analysis;Core Facility;Custom;Data;Data Analyses;data management;data quality;Data Reporting;design;Development;Disease;Educational process of instructing;empowerment;Ensure;exome sequencing;experience;Extramural Activities;Faculty;Feedback;Foundations;Funding;Human;Image;innovation;insight;Institution;instrumentation;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measures;medical schools;Mentorship;metabolomics;mid-career faculty;Mission;Modeling;Molecular;multimodality;multiple omics;neoplastic cell;Nuclear;operation;pancreatic neoplasm;patient derived xenograft model;Patients;personalized medicine;Pre-Clinical Model;Procedures;Process;protein function;Proteins;Proteomics;Quality Control;Radiation therapy;Radiobiology;radiomics;radioresistant;Reproducibility;Resource Sharing;sample collection;Sampling;Scientist;Signal Pathway;single cell ATAC-seq;single nucleus RNA-sequencing;single-cell RNA sequencing;Specimen;standard of care;Statistical Data Interpretation;Technology;Testing;Time;Training;transcriptome sequencing;Translations;tumor;tumor microenvironment;tumor-immune system interactions;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: METEOR-BioLogical Specimen Translation (METEOR-BLST)


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: RIVERSIDE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative The collection of molecules released into the extracellular environment by single cells, termed the single cell secretome, are windows into the complex milieu of proteins, RNA, metabolites, and other macromolecules which regulate cellular function. Up until now, secretome analysis has largely focused on secretions from populations of cells and use bulk measurement techniques that lack sensitivity. As a result, the single cell secretome is a blindspot in modern biology which will be rectified in this proposal using NanoSMS; a nanopore-based solution to secretome analysis and cellular fingerprinting.

PI_NAMEs: FREEDMAN, KEVIN  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Antibodies;Antibody Formation;Antigens;Autoimmune Diseases;B-Lymphocytes;Biology;cancer cell;Cell Communication;Cell Lineage;Cell Physiology;Cell Therapy;Cells;Collection;Complex;Development;Disease;Encapsulated;Environment;eosinophil;extracellular;Fingerprint;Glass;Human;Immune response;insight;Life;macromolecule;Malignant Neoplasms;Measurement;Measures;Methodology;Modernization;nanopore;new technology;Patients;Plasma Cells;Play;Population;Proteins;Regenerative Medicine;Retinal blind spot;RNA;Role;single molecule;Slide;stem cells;T-Lymphocyte;Techniques;Technology;Time;tool;Vesicle

PROJECT_TITLE: NanoSMS: single molecule secretome analysis for non-destructive cellular fingerprinting


NIH_SPENDING_CATS: Cancer;Data Science;Radiation Oncology

PI_NAMEs: LAI, ALBERT M (contact)

PROJECT_TERMS: Address;Adopted;Algorithmic Analysis;Atlases;Biological;Cells;Clinical Data;Collaborations;Collection;Data;Data Analyses;data ecosystem;data format;data ingestion;data integration;data management;data repository;data sharing;Data Sources;Databases;design;Digital Imaging and Communications in Medicine;Dose;Ecosystem;educational atmosphere;Ensure;experimental study;FAIR principles;genomic data;Genomic Data Commons;Genomics;Health;Health Insurance Portability and Accountability Act;Human;Image;image archival system;Informatics;innovation;Institution;Link;Manuals;Measures;metabolomics;Metadata;Multiomic Data;multiple data sources;multiscale data;Online Systems;open data;Outcome;Patients;Phenotype;Process;Productivity;Proteomics;Radiation Oncology;Radiation therapy;Reproducibility;Research;Resource Sharing;Sampling;Secure;Specimen;Structure;System;Tissues;tool;transcriptomics;TRUST principles;tumor;Universities;user-friendly;Visualization;Washington;web based software

PROJECT_TITLE: METEOR-Data Synthesis and Transfer (METEOR-DST)


PI_NAMEs: HUGO, GEOFFREY D (contact)

PROJECT_TERMS: Acceleration;Accreditation;Area;Biological Markers;Biology;biomedical informatics;Cancer Biology;cancer imaging;career development;certificate program;Clinical;Clinical Medicine;clinical translation;Clinical Trials Design;cohesion;Collaborations;Combined Modality Therapy;Communication;Competence;Complex;Data;data management;Data Science;data visualization;design;Development;digital;Discipline;Doctor of Philosophy;Ensure;Environment;Face;Faculty;Fellowship Program;Fostering;Foundations;Funding;Future;Goals;Image;Individual;Informatics;interdisciplinary collaboration;Interdisciplinary Study;International;Language;Leadership;Learning;learning materials;Machine Learning;Malignant Neoplasms;Medical;meetings;Mentors;Methodology;Methods;Modeling;Modernization;Molecular Biology;Molecular Immunology;multidisciplinary;Oncology;Pathway interactions;Persons;Physicians;Physics;Process;programs;Radiation;Radiation Oncologist;Radiation Oncology;radiation resistance;Radiation therapy;Radiobiology;Relapse;Research;Research Design;Research Personnel;Resource Development;Resources;Role;Science;Scientific Advances and Accomplishments;scientific organization;Series;skills;Societies;Students;success;symposium;Technology;theories;Time;tool;Training;Training Programs;treatment planning;tumor;Tumor Biology;tumor microenvironment;Tumor-Derived;tumor-immune system interactions;United States National Institutes of Health;Universities;virtual;Visualization;Washington;Work

PROJECT_TITLE: METEOR-Integrated Training Environment (METEORITE)


ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: Although cannabis use is common among Veterans with chronic pain, the harms (or benefits) of cannabis use among Veterans on long-term opioid therapy is unknown. Reported adverse events associated with use of Tetrahydrocannabinol (THC), the active component in cannabis, include sedation, confusion, loss of balance, nausea, vomiting, and hallucination. These side effects suggest that cannabis, when used in combination with opioids—which also cause sedation, confusion, respiratory depression, nausea, vomiting and constipation— may be harmful. On the other hand, several studies suggest that state-based recreational legalization may be associated with a decrease in opioid related deaths. Thus, it is plausible that cannabis use, by reducing the use of opioids, reduces respiratory depression and the risk of overdose. This proposal is directly responsive to research gaps identified by VA practice guidelines on the management of Veterans with chronic pain.

PI_NAMEs: KEYHANI, SALOMEH  (contact)

PROJECT_TERMS: 18 year old;Address;Adverse effects;Adverse event;Aging;Algorithms;Area;Behavior;Benzodiazepines;Cannabis;Cardiac;Caring;Categories;Chronic Obstructive Pulmonary Disease;chronic pain;chronic pain patient;Classification;Clinical;clinical practice;clinically relevant;cocaine use;Cognition;cohort;Cohort Studies;Confusion;Congestive Heart Failure;Constipation;Data;data mining;Data Sources;District of Columbia;Dizziness;dosage;Drug Screening;epidemiology study;Equilibrium;evidence base;fall injury;Frequencies;General Population;Guidelines;Hallucinations;Health;Heart Diseases;high risk;Hospitalization;human old age (65+);Individual;individual patient;Injury;innovation;Legal;Legal Medicine;Literature;marijuana use;marijuana user;Medicare;Memory impairment;Mental Health;Methodology;military veteran;Mood Disorders;mortality;Nausea;Opioid;opioid mortality;opioid therapy;opioid use;Outcome;overdose death;overdose risk;Pain management;patient screening;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Policies;Policy Maker;Population;Post-Traumatic Stress Disorders;Practice Guidelines;prescription opioid;Prevalence;primary outcome;Randomized, Controlled Trials;Recreation;Reporting;Research;Research Personnel;Respiration Disorders;respiratory;Risk;safety study;Scoring Method;secondary outcome;Sedation procedure;Series;side effect;Sleep Apnea Syndromes;Subgroup;Substance abuse problem;Suicide;Tetrahydrocannabinol;Text;Toxicology;Urine;Ventilatory Depression;Veterans;Vomiting;Woman

PROJECT_TITLE: Risks of Cannabis Use Among Veterans on Long-term Opioid Therapy

STUDY_SECTION_NAME: HSR-7 Capacity Building[HSR7]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Genetics

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Y at ha A hu Vai ryo Dr. Krishnamachary represents the ideal candidate for this Research Specialist award that will provide him with stability for the next five years. This award will allow him to use his exceptional expertise in molecular biology to advance research related to the tumor micro and macroenvironment as well as theranostics. Dr. Krishnamachary also has an excellent track record in training and mentoring.

PI_NAMEs: KRISHNAMACHARY, BALAJI  (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Award;cancer imaging;Career Mobility;Doctor of Philosophy;Environment;Funding;Gene Silencing;Genes;Genetic Transcription;Goals;Grant;Hypoxia;Hypoxia Inducible Factor;hypoxia inducible factor 1;In Vitro;in vivo Cellular and Molecular Imaging Centers;Invaded;Laboratory Research;Malignant Neoplasms;medical schools;Mentors;Methods;Mission;Molecular;Molecular Biology;Molecular Biology Techniques;molecular imaging;Monitor;nanoparticle delivery;Neoplasm Metastasis;Pathology;pediatric department;post-doctoral training;Postdoctoral Fellow;Productivity;programs;recruit;Renal Carcinoma;Research;Research Personnel;Research Project Grants;small hairpin RNA;Small Interfering RNA;Specialist;Talents;theranostics;Training;tumor;tumor microenvironment;tumor progression;Work

PROJECT_TITLE: INTEGRATING MOLECULAR BIOLOGY WITH CANCER MOLECULAR IMAGING AND THERANOSTICS


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Modern biomedical research is generating extensive information about the molecular basis of disease that will require individuals formally trained in both basic research and clinical medicine to advance this knowledge into discoveries that impact the human outcomes of disease. The goal of our multi-institutional MSTP is to pursue novel training of a diverse group of intellectually gifted students for careers as physician-scientists focused on disease-oriented research and bridging the knowledge gap between medicine and basic science.

PI_NAMEs: MILEWICZ, DIANNA M (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]