NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: LOPEZ, ANA MARIA  (contact)

PROJECT_TERMS: anti-cancer research;Appointment;Area;Back;Black race;Cancer Center;cancer health disparity;cancer research center director;career;Catchment Area;Cities;Collaborations;Communities;Data;Dedications;Development;digital health;Dimensions;disability;Diverse Workforce;diversity and equity;Educational process of instructing;Ensure;Environment;Equity;equity, diversity, and inclusion;Ethnic Origin;evidence base;Faculty;Fostering;Gender Identity;Generations;Goals;Government Agencies;health equity;Health Services;Heart;Hispanic;Income;Individual;Infrastructure;innovation;Institution;International;Justice;Knowledge;Latinx;Leadership;lens;Lesbian Gay Bisexual Transgender Queer;London;Malignant Neoplasms;Measures;Medical;Medical Oncology;Medicine;meetings;member;Minority Groups;Mission;Modeling;multidisciplinary;Neighborhoods;Pathway interactions;Philadelphia;Positioning Attribute;Postdoctoral Fellow;Process;professor;programs;Race;recruit;Reporting;Research;Research Personnel;Resources;satisfaction;Science;Scientist;Sex Orientation;Shapes;Strategic Planning;success;Thinking;Training;Training and Education;Translational Research;undergraduate student;Underrepresented Populations;Universities;Vision;Woman;Work

PROJECT_TITLE: Plan to Enhance Diversity (PED)


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PI_NAMEs: SIMONE, NICOLE L (contact)

PROJECT_TERMS: Address;Aging;Area;Awareness;Behavior Therapy;biomarker identification;cancer care;Cancer Center;Cancer Control;cancer education;cancer health disparity;cancer risk;Cancer Survivor;care delivery;Caring;Catchment Area;Cells;Clinical;clinical practice;Collaborations;Communities;community engagement;Community Outreach;community-level factor;computer framework;Development;dietary;Disparity;Doctor of Philosophy;Education;Equity;Event;Faculty;Faculty Recruitment;Fostering;Funding;Future;Genetic Risk;Goals;Grant;Health;health care availability;Health Disparities Research;health disparity;Health Policy;Health system;implementation science;implementation strategy;improved;improved outcome;Incidence;Individual;Internships;Intervention;Intervention Studies;investigator-initiated trial;Joints;Journals;Knowledge;Malignant Neoplasms;member;Methods;Minority;Mission;Molecular;Morbidity - disease rate;mortality;NCI-Designated Cancer Center;new technology;novel marker;Outcome;outcome disparities;patient population;Patient-Focused Outcomes;personalized intervention;Physicians;Pilot Projects;Policies;Population;population based;population health;Population Sciences;Prevention;Prognosis;programs;Public Health;Publishing;Quality of Care;Quality of life;quality of life for cancer survivors;recruit;Research;Research Personnel;Risk;Scientific Advances and Accomplishments;Scientist;Screening for cancer;Societies;Strategic Planning;structural determinants;Structural Racism;Students;Survivors;survivorship;symposium;therapy development;Toxic effect;Translating;translational pipeline;Translational Research;treatment adherence;Treatment outcome;Treatment-related toxicity;tumor progression;United States National Institutes of Health;Universities;Work;working group

PROJECT_TITLE: Research Program: Cancer Risk and Control (CRiC)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


PI_NAMEs: EISCHEN, CHRISTINE M. (contact)

PROJECT_TERMS: Address;Affect;Antibodies;Antibody Therapy;Awareness;bench-to-bedside translation;Blood;Cancer Center;cancer immunotherapy;cancer initiation;Cancer Patient;cancer survival;cancer therapy;cancer type;career development;Catchment Area;Cell Physiology;Cells;chimeric antigen receptor natural killer cells;chimeric antigen receptor T cells;Clinical;Clinical Treatment;Clinical Trials;Collaborations;Colon;Communities;Community Outreach;design;Development;Disparity;Doctor of Philosophy;Education;Educational process of instructing;effective therapy;Ensure;Environment;Event;Fostering;Funding;Funding Opportunities;Future;Goals;Grant;Head and Neck Cancer;Health Policy;Hematologic Neoplasms;Hematology;Hematopoietic Neoplasms;Immune;Immune system;Immunooncology;immunoregulation;Immunotherapy;improved;improved outcome;Incidence;innovation;insight;Investigational Therapies;Investments;Journals;Learning;Lung;Lymphoid Cell;Malignant lymphoid neoplasm;Malignant Neoplasms;Mediating;member;Mentors;Methods;Mission;Modality;Molecular;mortality;multidisciplinary;Multiple Myeloma;Myeloid Cells;Myeloproliferative disease;Natural Killer Cells;NCI-Designated Cancer Center;new therapeutic target;next generation;novel;novel strategies;Organ;Orphan;outreach;Paper;Pathway interactions;Patients;Population;Population Sciences;Postdoctoral Fellow;Productivity;programs;Proteins;Public Health;Publishing;Regulation;Research;Research Personnel;Research Training;Role;Scientist;Shapes;Solid;Solid Neoplasm;Strategic Planning;Students;synergism;T-Cell Lymphoma;T-Lymphocyte;targeted treatment;Testing;Therapeutic Intervention;Training;Training and Education;Translating;translational pipeline;Translational Research;treatment strategy;tumor;Tumor Expansion;tumor immunology;United States National Institutes of Health;Universities;Uveal Melanoma;Vaccines

PROJECT_TITLE: Research Program: Immune Regulation Targets (IRT)


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Precision Medicine;Rare Diseases;Women's Health Research

PI_NAMEs: SILVER, DANIEL P (contact)

PROJECT_TERMS: Address;Advocate;APOCEC3G gene;Award;Biological Assay;Biological Markers;brca gene;Breast;Cancer Center;cancer genetics;Cancer Patient;cancer type;career;Catchment Area;Cells;chromatin modification;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;Communities;community advisory board;Computational algorithm;Development;Disease;DNA;DNA Damage;DNA Repair;Doctor of Philosophy;early phase clinical trial;Epigenetic Process;Event;Faculty;Fellowship;Fostering;Funding;Future;Gene Expression Regulation;Genes;Genetic Transcription;Genome Stability;Genomic Instability;Genomics;Goals;Grant;Importins;improved;Incidence;innovation;innovative technologies;Innovative Therapy;insight;Journals;Laboratories;Leadership;Learning;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;meetings;member;Mentors;Mentorship;Mission;Molecular;molecular oncology;Molecular Target;molecular targeted therapies;mortality;new technology;novel;Nuclear;Nuclear Pore Complex;nucleocytoplasmic transport;Outcome;outreach;Pathogenesis;Patients;Phase;posttranscriptional;Precision therapeutics;predictive tools;Prevention;Process;prognostic;programs;Prostate;Publishing;recruit;Regulation;Research;Research Personnel;Resistance;resistance mechanism;response;Role;Scientist;screening;Silver;Site;Small RNA;Strategic Planning;synergism;targeted treatment;telomere;Testing;Time;Training and Education;Training Programs;Transcriptional Regulation;Translating;Translational Research;translational scientist;translational study;Translations;triple-negative invasive breast carcinoma;tumor progression;tumorigenesis;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Research Program: Molecular Oncology Regulation Approaches (MORA)


NIH_SPENDING_CATS: Cancer

PI_NAMEs: REGINATO, MAURICIO J. (contact)

PROJECT_TERMS: Address;Advocate;Area;Award;biobank;biomedical referral center;cancer cell;Cancer Cell Growth;Cancer Center;Cancer Patient;cancer survival;career;Catchment Area;Cell Communication;cell growth;Cell Signaling Process;Cell Survival;Cells;Cellular Metabolic Process;cellular oncology;Clinic;Clinical;Clinical Trials;Collaborations;combinatorial;Communities;community advisory board;Cytokine Signaling;Detection;Distant;Doctor of Philosophy;drug discovery;Drug Tolerance;Early Diagnosis;Early treatment;Evolution;faculty mentor;Fellowship;Fellowship Program;Financial Support;Fostering;Funding;Future;G Protein-Coupled Receptor Signaling;Glycolysis;Goals;Grant;Head and Neck Cancer;Human;Image;imaging approach;imaging modality;Imaging technology;improved;Incidence;Journals;laboratory experience;Learning;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;member;Mentorship;Metabolic;Metabolic Pathway;Metabolism;Mission;Mitochondria;mitochondrial metabolism;Mitogens;mortality;Nature;NCI-Designated Cancer Center;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;novel diagnostics;novel therapeutic intervention;Oncology;oncology program;Outcome;outreach;Pathway interactions;Patients;Pharmacology;Primary Neoplasm;programs;Property;Publishing;Recurrence;Research;Research Personnel;Resistance;Role;Scientist;Signal Pathway;Signal Transduction;Strategic Planning;Stromal Cells;Students;synergism;targeted cancer therapy;targeted treatment;Teacher Professional Development;technology intervention;Therapeutic Intervention;therapeutic target;Tissue Expansion;Training and Education;training opportunity;Training Programs;trait;Translating;translational clinical trial;translational goal;translational oncology;Translational Research;Translations;Treatment outcome;tumor;tumor growth;tumor microenvironment;tumor progression;Underrepresented Minority;United States National Institutes of Health;Universities;Uveal Melanoma

PROJECT_TITLE: Research Program: Translational and Cellular Oncology (TaCO)


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: LEADER, AMY  (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Advocate;anti-cancer research;Behavior;Cancer Burden;Cancer Center;cancer health disparity;Cancer Patient;Caregivers;Catchment Area;Cessation of life;Cities;Clinical Trials;Collaborations;Colon;Communication;Communities;community academic partnership;community advisory board;community consultation;community engagement;Community Health Education;Community Outreach;Community Participation;County;Data;Data Collection;Data Science;Data Sources;Death Rate;Dimensions;Disparity;Education and Outreach;Ensure;equity, diversity, and inclusion;evidence base;Evidence based intervention;Exhibits;experience;Family;Fostering;Goals;high risk;Incidence;Infrastructure;Language;Link;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;member;Mentors;Mission;Monitor;Multiple Myeloma;NCI Center for Cancer Research;neoplasm resource;next generation;novel;novel strategies;Outcome;outreach;patient oriented;Patients;Philadelphia;Policies;policy recommendation;Population;Positioning Attribute;Process;programs;Prostate;public education;Reporting;Research;Research Personnel;Research Support;Resources;Schools;Screening for cancer;Services;social health determinants;Students;success;Survivors;synergism;Time;Training and Education;Translational Research;trend;underserved community;Universities;Visualization;working group

PROJECT_TITLE: Community Outreach and Engagement


PI_NAMEs: HUESSER, MATTHEW HOWARD (contact)

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;anti-cancer research;Automation;Award;base;Basic Science;bench to bedside;Breast;Cancer Center;Cancer Center Support Grant;cancer health disparity;Cancer Research Project;cancer statistics;Catchment Area;Clinical;clinical development;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Collection;Colorectal;Communities;community center;Data;Dedications;Development;Developmental Process;Ensure;Environment;Fostering;Funding;Funding Opportunities;geographic disparity;Geographic Information Systems;Goals;health equity;Individual;Infrastructure;innovation;Institution;interdisciplinary collaboration;Intervention;investigator-initiated trial;Investments;Leadership;Lung;Malignant Neoplasms;Maps;Medicine;member;Mission;Multiple Myeloma;NCI-Designated Cancer Center;next generation;Outcome;Patient Recruitments;Patient-Focused Outcomes;Peer Review;Phase;Philadelphia;Pilot Projects;Policies;Population;Population Sciences;Process;programs;Prostate;Publications;Reporting;Research;Research Personnel;Research Project Grants;Research Proposals;Resource Sharing;Risk Factors;Science;Scientist;Secure;service utilization;Services;social health determinants;Strategic Planning;synergism;Technology;The Wistar Institute;Time;tool;Training;Translational Research;Wages

PROJECT_TITLE: Developmental Funds


PI_NAMEs: SCHNELL, MATTHIAS JOHANNES (contact)

PROJECT_TERMS: Accountability;Advisory Committees;anti-cancer research;Applications Grants;authority;Award;bioimaging;Bioinformatics;Biometry;Businesses;Cancer Center;Cancer Center Support Grant;cancer genomics;cancer research center director;Catchment Area;Collaborations;Communication;Communities;Consultations;Core Facility;cost effective;cost effectiveness;Data;Data Analytics;Dedications;Development;Direct Costs;Doctor of Philosophy;Education;Education and Outreach;Ensure;Evaluation;Exercise;Faculty;Feedback;Flow Cytometry;Fostering;Funding;Goals;Human;Immunologic Monitoring;improved;Informatics;Infrastructure;innovation;insight;Institution;instrument;instrumentation;interdisciplinary collaboration;Investments;large language model;large scale data;Leadership;Location;Machine Learning;Malignant Neoplasms;member;Mission;Modernization;Names;Natural Language Processing;NCI Center for Cancer Research;operation;outreach;Pathology;Performance;Policies;Population Sciences;Positioning Attribute;preference;Procedures;Process;Productivity;programs;Recommendation;Records;Reproducibility;Research;Research Personnel;Resource Sharing;satisfaction;Services;Strategic Planning;structural biology;Surveys;Technology;Training;Translational Research;Universities;Update;voucher

PROJECT_TITLE: Shared Resource Management


PI_NAMEs: CHAPMAN, ANDREW  (contact)

PROJECT_TERMS: Advocate;Appointment;Cancer Burden;Cancer Center;Cancer Detection;Cancer Patient;cancer therapy;Caregivers;Catchment Area;Clinical;clinical care;Clinical Research;Communities;community advisory board;community organizations;Compassion;County;Data;Development;disparity elimination;diversity and inclusion;Education;Elderly;Ensure;Environment;equity, diversity, and inclusion;Evaluation;Family;Feedback;Fostering;Funding;Future;Goals;Growth;Health;Health system;improved;Infrastructure;innovation;Institution;International;Investments;Leadership;lens;Malignant Neoplasms;Measures;member;Mission;Monitor;Motivation;NCI Center for Cancer Research;NCI-Designated Cancer Center;Oncology;oncology service;Outcome;outreach;Patients;personalized cancer care;Philadelphia;Population;Process;programs;recruit;Research;Research Infrastructure;Research Personnel;Resource Allocation;Resource Sharing;Resources;Scientist;Services;Shapes;Strategic Planning;success;System;Talents;Testing;Training;Training and Education;Translational Research;underserved community;Universities;Vision

PROJECT_TITLE: Leadership, Planning, and Evaluation


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety

PI_NAMEs: KELLY, WILLIAM K. (contact)

PROJECT_TERMS: Adult;anti-cancer research;Area;arm;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Patient;cancer research center director;career development;Clinical;Clinical Cancer Center;Clinical Data;Clinical Protocols;Clinical Research;clinical trial recruitment;Clinical Trials;Collaborations;Communication;Communities;community engagement;Community Outreach;community partners;community research;Complex;Comprehensive Cancer Center;Data Coordinating Center;data management;data quality;Data Reporting;Dedications;Development;Disease;drug development;Education;Enrollment;Ensure;Goals;Growth;Health;improved;Individual;Informatics;Infrastructure;Institution;Institutional Review Boards;Interdisciplinary Study;investigator-initiated trial;Investments;Leadership;life span;Malignant Neoplasms;member;Minority;Monitor;Monitoring Clinical Trials;multidisciplinary;novel;Operations Research;Patients;Phase;phase 1 study;Physician Executives;Program Development;programs;Protocols documentation;quality assurance;recruit;Regulation;Reporting;Research;Research Personnel;research study;Research Support;Risk;Role;Safety;screening;Services;Solid;Structure;success;Time;Training;Training and Education;Translational Research;Universities;Woman;Work

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Address;Adult;anti-cancer research;authority;Cancer Center;Catchment Area;Charge;Clinical;Clinical Cancer Center;Clinical Management;Clinical Research;Clinical Research Protocols;Clinical Trials;Clinical Trials Design;Communities;Concept Review;Conduct Clinical Trials;design;Diagnosis;Discipline of Nursing;Disease;Ensure;Equity;Feasibility Studies;Genetic;Goals;human subject;Industry;Institutional Review Boards;investigator-initiated trial;Laboratories;life span;Malignant Neoplasms;Measures;Medical Oncology;Minority Groups;Mission;Monitor;multidisciplinary;Office Management;Outcome;Pathology;patient population;Peer Review;Pharmacists;Pharmacy facility;Phase;Physicians;Population;Prevention;Process;programs;Protocols documentation;quality assurance;Radiation Oncology;Radiology Specialty;Recommendation;Regimen;Research;Research Personnel;research study;Scientific Advances and Accomplishments;Scientist;Screening procedure;Site;sound;Staging;Strategic Planning;study population;Surgical Oncology;System;Translational Research;Translations;Underserved Population;Universities;Voting;Woman

PROJECT_TITLE: Protocol Review and Monitoring


NIH_SPENDING_CATS: Biotechnology;Cancer;Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: LEIBY, BENJAMIN  (contact)

PROJECT_TERMS: anti-cancer research;Applications Grants;Area;Basic Science;biobank;Bioinformatics;Biometry;Biostatistics Shared Resource;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;Catchment Area;Clinical;Clinical Cancer Center;clinical database;clinical development;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;community engagement;Community Outreach;Computerized Medical Record;Data;Data Analyses;Data Analytics;Data Collection;data integration;data management;Data Science;database design;Databases;design;Development;diverse data;Doctor of Philosophy;Education;Educational process of instructing;Ensure;Faculty;Funding;genomic data;Goals;Human Resources;Informatics;informatics shared resource;innovation;Instruction;Leadership;lectures;Malignant Neoplasms;Manuscripts;member;Methods;Monitor;operation;Pathology;Patient Outcomes Assessments;Peer Review;Pharmacology;Physiology;Play;Population;Population Research;Population Sciences;Preparation;programs;Protocols documentation;Publications;recruit;Registries;Reporting;Research;Research Activity;Research Design;Research Personnel;Resource Sharing;Resources;Role;Safety;Scientist;service delivery;Services;Source;Strategic Planning;Techniques;Training;Training and Education;Translational Research;translational study;Walking;Writing

PROJECT_TITLE: Biostatistics, Bioinformatics, and Research Informatics Shared Resource


PI_NAMEs: GIRAUDO, CLAUDIO GUILLERMO (contact)

PROJECT_TERMS: Acceleration;anti-cancer research;Applications Grants;base;bioimaging;Biological Sciences;Cancer Center;Cancer Center Support Grant;Capital;Communities;Computer Hardware;Computer software;confocal imaging;Consultations;Contract Services;cost effective;Counseling;Data;Data Analyses;Development;Doctor of Philosophy;Education;Educational workshop;Ensure;Equipment;experience;Fluorescence;Funding;Future;Goals;graduate student;Human Resources;Image;Image Analysis;imaging modality;imaging system;improved;instrument;instrumentation;Laboratories;Lasers;light microscopy;live cell imaging;Malignant Neoplasms;meetings;member;Microscope;Microscopy;Modernization;Monitor;NCI Center for Cancer Research;new technology;novel;Peer Review;programs;Publications;recruit;Research;Research Personnel;Resource Sharing;Resources;Scanning;Schedule;Scientist;Services;Site;Strategic Planning;System;Technology;theories;tool;Training;Training and Education;Translational Research;ultra high resolution;Update;Visualization;Walking;Work

PROJECT_TITLE: BioImaging Shared Resource


PI_NAMEs: WIGDAHL, BRIAN  (contact)

PROJECT_TERMS: Applications Grants;Basic Science;Bioinformatics;bioinformatics pipeline;Biological Models;Biological Sciences;biological systems;Biology;Cancer Center;cancer genomics;Cells;Chromium;Clinical Research;Clinical Trials;Collaborations;college;Communicable Diseases;Consultations;Correlative Study;cost;Cutaneous;Data;data acquisition;Data Analyses;Data Collection;Department chair;Dermatology;design;Development;Disease;DNA;DNA analysis;DNA sequencing;Doctor of Philosophy;Educational process of instructing;Epigenetic Process;Equipment;Experimental Designs;Faculty;flexibility;Fostering;functional genomics;Funding;Future;gene therapy;Genetic;Genome;genome analysis;genomic data;Genomics;Genomics Shared Resource;Goals;Human Resources;Immunology;Instruction;instrument;instrumentation;Laboratories;Leadership;lectures;Libraries;Liquid substance;Malignant Neoplasms;Manuscripts;member;Methodology;Methods;microbial genome;Microbiology;microbiome analysis;Microscopy;Molecular Medicine;Molecular Virology;multiple omics;nanopore;novel strategies;operation;Output;Peer Review;Phase;Pilot Projects;Play;Population Research;Preparation;programs;Publications;Research;Research Personnel;Research Project Grants;RNA;RNA analysis;Robot;Role;sample fixation;Sampling;Scientist;Services;single cell analysis;Site;Strategic Planning;targeted sequencing;Technology;Testing;Tissues;Training;Training and Education;transcriptome sequencing;transcriptomics;Translational Research;Universities;user-friendly;Walking;whole genome;Work

PROJECT_TITLE: Cancer Genomics Shared Resource


PI_NAMEs: HARSHYNE, LARRY A (contact)

PROJECT_TERMS: Antibodies;Applications Grants;Basic Science;Biological;Biological Assay;Biological Sciences;Cancer Center;Cancer Center Support Grant;cell analyzer;Cell Separation;Cells;Clinical;clinical investigation;Clinical Investigator;Clinical Trials;Complex;cytokine;Cytometry;data acquisition;Data Analyses;design;Development;digital;Doctor of Philosophy;Education;Educational workshop;Equipment;experience;Experimental Designs;extracellular vesicles;Flow Cytometry;Flow Cytometry Shared Resource;Fluorescence-Activated Cell Sorting;Funding;Future;Goals;Growth Factor;high throughput analysis;Human;Immune;immune function;immune health;Immunologic Monitoring;Immunology;Immunology procedure;Institution;Instruction;instrument;instrumentation;Investments;large datasets;Lasers;Learning;lectures;Malignant Neoplasms;member;Methods;Microbiology;mid-career faculty;Monitor;Multiparametric Analysis;nano-string;nanoparticle;novel;participant enrollment;particle;Patients;Peer Review;Price;Process;programs;Protocols documentation;Publications;Reader;recruit;Research;Research Personnel;Resource Sharing;Retirement;Role;S10 grant;sample collection;Sampling;Services;Specimen;Specimen Handling;Stains;Standardization;Strategic Planning;System;Techniques;Time;Training;Training and Education;transcriptomics;Translational Research;translational scientist;tumor immunology;United States National Institutes of Health;Vesicle;Walking;Work;working group

PROJECT_TITLE: Flow Cytometry Human Immune Monitoring Shared Resource


PI_NAMEs: CINGOLANI, GINO  (contact)

PROJECT_TERMS: Applications Grants;Archives;Binding;Biochemistry;Biological;biological systems;biophysical techniques;Biophysics;Cancer Center;Cancer Center Support Grant;Complex;Computer software;Consult;Cryoelectron Microscopy;Crystallography;Data;Data Analyses;Data Collection;Data Storage and Retrieval;Department chair;design;detector;Development;Doctor of Philosophy;Dose;Electron Microscope;empowerment;Environment;Evolution;experience;Experimental Designs;experimental study;Funding;Funding Mechanisms;Future;Goals;Grant;Human Resources;Image;Individual;instrument;instrumentation;interest;Investigation;Ions;Logistics;macromolecule;Malignant Neoplasms;member;Methodology;Methods;Mission;Molecular Biology;Molecular Structure;Mutation;Names;operation;particle;Peer Review;Preparation;professor;programs;protein folding;Publications;Reproducibility;Research;Research Personnel;Resource Sharing;Sampling;Scientist;Services;Specimen;Strategic Planning;structural biology;Structure;Training;Translational Research;Walking;X-Ray Crystallography

PROJECT_TITLE: Integrated Structural Biology Shared Resource


PI_NAMEs: JIANG, WEI  (contact)

PROJECT_TERMS: Accreditation;American;Anatomy;animal tissue;Animals;anti-cancer research;Applications Grants;biobank;Biological;Biological Sciences;Blood Cell Count;Blood specimen;Cancer Center;Cancer Center Support Grant;Capital;Charge;Clinical;Clinical Pathology;Clinical Trials;Collaborations;college;Consultations;Counseling;Data;Development;digital pathology;Doctor of Philosophy;Education;Ensure;Equipment;Evaluation;experience;Experimental Designs;Experimental Pathology;Faculty;Formalin;Freezing;Funding;Future;Genomic medicine;Goals;Grant;Growth;Harvest;Hematology;Histopathology;human tissue;Image;Image Analysis;Image Enhancement;Immunohistochemistry;In Situ Hybridization;Individual;instrumentation;Laboratories;Leadership;Malignant Neoplasms;member;molecular pathology;Morphology;novel;Oncology;operation;Organ;Paraffin Embedding;Pathologic;Pathologist;Pathology;patient population;Patients;Peer Review;Preparation;programs;Protocols documentation;Publications;Research;Research Assistant;Research Personnel;Resource Sharing;S10 grant;Sampling;Scanning;Services;Slide;Stains;Strategic Planning;Techniques;Tissue Banks;Tissue Embedding;Tissue Engineering;Tissue Sample;Training;Training and Education;Translational Research;Visual;Visualization;Vocational Education;Walking;Workload

PROJECT_TITLE: Translational Pathology Shared Resource


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: This program will train future leaders in environmental toxicology to facilitate the discovery of mechanisms underlying the effects of environmental exposures on human health and disease. Our program focuses on mechanistic molecular toxicology and translational applications to human disease and leverages an outstanding training environment to develop exceptional environmental health science researchers and ensure the availability of a diverse and highly trained workforce.

PI_NAMEs: CHERRINGTON, NATHAN J (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TITLE: Training in Environmental Toxicology of Human Disease

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS (T)]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The UCSF Dermatology Training Program encourages physician scientist trainees to pursue cutting edge research and prepares them for a lifetime of scholarly pursuits with the ultimate goal of understanding the molecular and social determinants of skin diseases, identifying new therapies for these diseases, and ensuring that scientific discoveries lead to advances in public health in an equitable and cost-effective manner.

PI_NAMEs: LIAO, WILSON  (contact);ROSENBLUM, MICHAEL DAVID

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Dermatology;Grant;Training

PROJECT_TITLE: UCSF Dermatology Training Grant

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 SP (M1)]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: SAGE BIONETWORKS

ORG_STATE: WA

PHR: PROJECT NARRATIVE Alzheimer's disease is a complex brain disorder that affects millions of Americans, but there are limited options to prevent or treat it. The National Institute on Aging has funded numerous research groups that use open science to better understand the disease and develop new treatments. The AD Knowledge Portal Data Coordination Center helps these researchers collaborate with one another and share their findings through online platforms to improve our understanding of Alzheimer's and find effective treatments.

PI_NAMEs: HEATH, LAURA MICHELLE (contact);VARMA, SUSHEEL

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: Acceleration;Address;Adoption;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;American;Biological Markers;Biological Models;Biological Process;Biology;Brain Diseases;career;cohort;Collaborations;Communities;Complex;computational platform;Computing Methodologies;Data;data access;Data Coordinating Center;Data Discovery;data harmonization;data infrastructure;data portal;data reuse;Data Science;Data Set;data standards;Democracy;design;Disease;disease heterogeneity;drug development;drug discovery;Ecosystem;Educational workshop;effective therapy;effectiveness evaluation;Ensure;Environmental Risk Factor;Evaluation;evidence base;FAIR principles;Funding;Genetic;Goals;Grant;improved;Individual;Infrastructure;insight;Interdisciplinary Study;Internships;interoperability;Investments;Knowledge Portal;Lead;Link;Medicine;Meta-Analysis;metadata standards;Mission;Molecular;National Institute on Aging;Nature;Neurodegenerative Disorders;novel;open data;Output;outreach;pre-clinical;precision medicine;prevent;Process;programs;Publications;repository;Research;Research Personnel;Research Project Grants;Resources;Science;Series;System;Systems Biology;Therapeutic;tool;Training;translational medicine;Translational Research;Validation;working group

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-S (J1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative The UC Irvine Center for Neural Circuit Mapping T32 Training Program will prepare the next generation of basic science researchers with an emphasis on neural circuit analysis of Alzheimer’s disease and related dementias. Our program emphasizes training young scientists with the cutting-edge, collaborative and interdisciplinary research that will be required to identify new therapeutic targets and to develop innovative tools for treating Alzheimer disease and related dementias.

PI_NAMEs: HOLMES, TODD C;XU, XIANGMIN  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Alzheimer's Disease;Maps;neural circuit;Research;Training Programs

PROJECT_TITLE: The UC Irvine Center for Neural Circuit Mapping training program in Alzheimer's disease research

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (J2)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health

PHR: Project Narrative Mental illness is a major cause of morbidity and disability in the United States and basic neurobiological mechanisms, particularly related to learning and memory function and dysfunction, remain elusive. This is a proposal for the renewal of the Howard Schneiderman T32 Training Program in Learning and Memory, which uses a transdisciplinary approach to cut across basic and clinical/translational science as well as across species and techniques. By combining advanced coursework and lab training with rigorous team science approaches, this program will continue to train the next generation of leaders in neuroscience, and equip them with the knowledge, tools, and experience to address the grand challenge of mental illness.

PI_NAMEs: MCNAUGHTON, BRUCE L;YASSA, MANUELLA ;YASSA, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Learning;Memory;Training Programs

PROJECT_TITLE: Howard Schneiderman Training Program in Learning and Memory

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (01)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The mission of the Tissue Engineering Resource Center is to transform the field of tissue engineering and its therapeutic applications by developing next-generation technologies for engineering human tissues. We anticipate that the Center will enable transformative modalities in regenerative medicine and the treatment of diseases, while also providing collaborations, service, training, dissemination, and outreach to both the tissue engineering community and the general public.

PI_NAMEs: VUNJAK-NOVAKOVIC, GORDANA  (contact)

PROGRAM_OFFICER_NAME: RUSSELL, LUISA MARIE

PROJECT_TERMS: Advisory Committees;Area;Automation;Awareness;Basic Science;Biocompatible Materials;Biological;Biomedical Engineering;Bioreactors;Biosensor;Blood Vessels;Cancer Patient;Cardiac;Cells;Circulation;Clinic;Clinical;clinical application;clinical translation;Collaborations;commercial application;Communities;design;Development;Disease;disease model;driving force;Engineering;Ensure;Event;Evolution;experience;Feedback;Financial Support;Fostering;Functional disorder;functional restoration;General Population;Generations;Geographic Distribution;Goals;Human;Human Engineering;human tissue;Image;Immune;improved;In Vitro;in vivo;Injury;innovation;Institution;Lead;Leadership;Letters;Link;lung regeneration;Measurement;Measures;Medical center;meetings;Minority;Mission;Modality;Modeling;new technology;next generation;operation;Optics;Organ;Organ Model;organ regeneration;outreach;outreach program;Patients;Physiological Processes;Play;Productivity;program dissemination;Property;Rapid screening;Recording of previous events;regeneration model;Regenerative Medicine;Reporter;Research;Research Ethics;Research Personnel;Research Project Grants;Resources;response;restoration;Role;scaffold;Schools;Science;Services;Signal Transduction;spatiotemporal;Strategic Planning;Structure;Students;Synovial joint;System;Technology;technology development;technology research and development;technology validation;Therapeutic;Time;tissue culture;Tissue Engineering;Tissue Model;tissue regeneration;tissue support frame;Tissues;Training;Translating;Translational Research;Translations;underserved community;Universities;Visualization;Woman

PROJECT_TITLE: Tissue Engineering Resource Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-C (J1)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Regenerative Medicine

PROJECT_TITLE: Tissue Engineering Resource Center: Admin-Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PI_NAMEs: KAPLAN, DAVID L. (contact)

PROJECT_TERMS: 3-Dimensional;3D Print;Address;Adhesions;Aging;Alginates;Animals;Anti-Inflammatory Agents;Apoptotic;Area;Biochemical;Biocompatible Materials;Biodegradation;Biological;Biology;Bionics;Biopolymers;bioprinting;Blood capillaries;capsule;Cell Adhesion;Cell Differentiation process;Cell Lineage;Cell Physiology;Cell Survival;Cell Transplantation;Cells;Chemicals;Chemistry;chemokine;Clinical;controlled release;cytokine;Cytoprotection;Data;delivery vehicle;deprivation;design;Diagnostic;Differentiation and Growth;Disease;disease model;Disease Progression;Encapsulated;Engineering;environmental stressor;Event;Extracellular Matrix;fabrication;Fibrosis;functional improvement;Future;Gel;Gelatin;Goals;Grant;Health;Heart;Hormones;Human;human stem cells;human tissue;Hyaluronic Acid;hydrodynamic flow;Hydrogels;Immune;Immune Evasion;Immune response;Immune Targeting;immunoregulation;Implant;implantation;improved;In Vitro;in vitro Model;in vivo;Inflammation;Inflammatory;Inflammatory Response;Injections;Injury;insight;Intervention;Investigation;Ions;Light;lipid mediator;Liver;Lung;Mammalian Cell;mechanical force;mechanical properties;Mechanics;Medical;Modeling;Modification;Monitor;nanocoating;Natural regeneration;Needles;Neurons;novel;novel strategies;Organoids;Outcome;Oxygen;Physiologic Monitoring;Physiological;Physiology;Polymers;preservation;proband;Process;Property;Proteins;Protocols documentation;Radiation;real time monitoring;Recombinants;Reducing Agents;regenerative;Regenerative Medicine;regenerative treatment;Reporter;Reporting;Resolution;Resources;response;Rodent;scaffold;sensor;Silk;stem;stem cells;Stimulus;subcutaneous;System;Tattooing;Temperature;Testing;Therapeutic;Time;tissue culture;Tissue Engineering;Tissue Model;tissue regeneration;Tissues;Translating;Translations;Transplantation;Validation;Vertebral column

PROJECT_TITLE: Tissue Engineering Resource Center: TR&D1


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: HUNG, CLARK T. (contact)

PROJECT_TERMS: Acute;advanced system;Age;Aging;Anatomy;Animal Model;arthropathies;articular cartilage;Autoantibodies;Autoimmune myocarditis;Benchmarking;Biocompatible Materials;Biodiversity;Biological;Biological Markers;Biophysics;Bioreactors;Blood Vessels;Body System;bone;Bone Marrow;Cancer Model;Cardiac;cardiac tissue engineering;Cardiotoxicity;Cardiovascular Diseases;Cardiovascular Physiology;Cartilage;Cell Communication;Cell Differentiation process;Cell model;Cells;Chronic;Circulation;Clinical;Clinical Data;Commercial Sectors;Communication;controlled release;Controlled Study;design;Development;Dilated Cardiomyopathy;Disease;drug development;Endothelial Cells;Engineering;Event;Fatty acid glycerol esters;Feedback;Fibroblasts;Fibrosis;Functional disorder;Gene Targeting;Generations;Genotype;Goals;Gonadal Steroid Hormones;Heart;Heart Diseases;heart function;Heart Injuries;Human;Human Engineering;human induced pluripotent stem cells;human model;Human Pathology;human tissue;Image;imaging capabilities;Immune;Individual;induced pluripotent stem cell;Inflammation;inhibitor;Injury;Intervention;Joints;Kinetics;Left;Ligaments;Link;Liquid substance;Liver;liver metabolism;Macrophage;Mechanical Stimulation;Meniscus structure of joint;Metabolic;Methods;Microfluidics;Modality;Modeling;Myocardial;Natural regeneration;Neoplasm Metastasis;Neuromuscular Junction;next generation;Optics;optogenetics;Organ;organ on a chip;Patients;Perfusion;Permeability;Phenotype;Physiological;Physiology;Play;precision medicine;Property;real time monitoring;real-time images;Reperfusion Injury;Resources;response;Restrictive Cardiomyopathy;Role;Sampling;Scientist;sex;Signal Pathway;Skin;spatiotemporal;Standardization;Synovial joint;Synovial Membrane;System;Systemic disease;Technology;Testing;Time;Tissue Engineering;Tissue Model;Tissues;Transforming Growth Factor beta Receptors;Translations;user-friendly;Vascularization;Visualization

PROJECT_TITLE: Tissue Engineering Resource Center: TR&D2


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Lung;Regenerative Medicine;Women's Health Research

PROJECT_TERMS: Acute;Affect;Air;Biochemical;Biological;Biological Process;Bioluminescence;Biomedical Research;Biophysics;Bioreactors;bioscaffold;Biosensing Techniques;Biosensor;Blood Vessels;bone;Bone Marrow;Breast Cancer Patient;cancer cell;Cancer Model;cardiac regeneration;Cardiopulmonary;Cells;Cellular Structures;Characteristics;Chronic Phase;Circulation;Clinical;Clinical Data;clinically relevant;computerized;Congenital Abnormality;Cystic Fibrosis;Dedications;design;Development;Disease;disease model;Engineering;Environment;Exhibits;Extravasation;Family suidae;Fluorescence;Genetic Diseases;Genotype;Heart;Hour;Human;human tissue;Image;imaging modality;Immune;Impairment;improved;In Situ;Individual;induced pluripotent stem cell;injured;Injury;innovation;instrument;Light;Link;Liver;Lung;lung injury;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Mechanics;Medicine;metastasis prevention;Metastatic breast cancer;mimetics;Modality;Modeling;Molecular;Monitor;Mucous body substance;multimodality;Myocardial Infarction;nanotherapeutic;Natural regeneration;Neoplasm Metastasis;next generation;non-invasive monitor;novel;Optics;Organ;Organ Culture Techniques;organ on a chip;organ regeneration;Pathology;Patients;Phase;Phenotype;Physiological;Play;Property;Protocols documentation;Recovery;Regenerative engineering;Regenerative research;repair model;repaired;Reperfusion Injury;Research;Resources;response;Role;Signal Transduction;Site;Specificity;Structure;Support System;System;targeted delivery;Technology;Testing;Therapeutic;therapeutic candidate;Therapeutic Studies;Time;tissue culture;Tissue Engineering;tissue injury;tissue regeneration;Tissues;translational study;Translations;treatment strategy;Validation;Vascular Endothelium;viscoelasticity;Woman

PROJECT_TITLE: Tissue Engineering Resource Center: TR&D3


PROJECT_TERMS: African American student;Area;Awareness;Biomedical Engineering;career;Career Choice;Charge;Clinic;clinical application;Clinical Research;Collaborations;college;commercialization;Communities;cost;design;Development;Education and Outreach;Educational process of instructing;Educational workshop;Engineering;Entrepreneurship;equity, diversity, and inclusion;Faculty;Feedback;Funding;General Population;girls;graduate student;Grant;High School Student;insight;interest;Internships;Joints;junior high school;Knowledge;Laboratories;Learning;learning engagement;lectures;Link;Medical;Medical Students;Middle School Student;Mind;Modality;National Institute of Biomedical Imaging and Bioengineering;Online Systems;operation;outreach;Participant;podcast;Population;programs;Research;Research Personnel;Residencies;Resources;Role;Running;Schools;Science;Scientist;Series;skills;Specialist;stem cells;Students;summer program;summer research;symposium;Technology;technology development;technology training;Tissue Engineering;Tissues;Training;training opportunity;Training Programs;Translational Research;Translations;undergraduate research experience;undergraduate student;underserved community;Universities;Update;virtual;web site

PROJECT_TITLE: Tissue Engineering Resource Center: TTD


ADMINISTERING_IC: DK

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Obesity

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: PROJECT NARRATIVE  Obesity is a complex disease that occurs through genetic and epigenetic mechanisms and their interactions with the environment. The objective of the Training in Obesity Research Program at Pennington Biomedical Research Center is to train the highest caliber of postdoctoral fellows to understand the complex interactions between genetic, molecular, physiological, behavioral and environmental aspects of obesity and become productive research scientists in obesity with the capability of establishing successful scientific careers in academia, academic medicine, governmental agencies, and in the private sector.

PI_NAMEs: MORRISON, CHRISTOPHER D;REDMAN, LEANNE MAREE (contact)

PROGRAM_OFFICER_NAME: KAMARA, FANTA

PROJECT_TERMS: Obesity;Research;Training

PROJECT_TITLE: Training in Obesity Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-W (J1)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases;Natural Products;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: FULLERTON

ORG_DEPT: CHEMISTRY

ORG_NAME: CALIFORNIA STATE UNIVERSITY FULLERTON

PHR: Project Narrative The botulinum neurotoxin, which causes the paralytic disease botulism is the most lethal toxin known to man with only 1 gram of the toxin can kill 1 million people. The toxin has the potential to be used as a weapon for bioterrorism and current antitoxin treatments for botulism are not practical in the event of a wide scale biological attack as the antitoxin has many drawbacks including limited supply, allergic reaction and limited treatment window. Our laboratory has discovered dipeptides as a potential treatment for botulism and will further study the dipeptides through chemical synthesis, enzyme assays and pharmacokinetic studies to fully evaluate the dipeptides as a therapeutic for the rapid treatment of botulism.

PI_NAMEs: SALZAMEDA, NICHOLAS THOMAS (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Active Sites;Allergic Reaction;anti-toxin;Binding;Biological;Biological Assay;Biological Warfare;Biomedical Research;Bioterrorism;bioweapon;Body Weight;Botulinum Toxin Type A;Botulinum Toxins;Botulism;career;Categories;Cells;Centers for Disease Control and Prevention (U.S.);Cessation of life;chemical synthesis;Classification;cost;Coupled;Custom;Cytosol;Data;design;Diagnosis;Dipeptides;Disease;Dose;Drug Design;drug discovery;Drug Kinetics;Elements;Enzyme Inhibition;Enzymes;Evaluation;Event;experience;FDA approved;Feedback;Future;Future Generations;General Population;Generations;Goals;Human;improved;inhibitor;Intervention;Intoxication;Laboratories;laboratory experience;Laboratory Research;Lead;lethal factor;Libraries;Light;man;Mentorship;Metabolic;Metalloproteases;Modification;mortality;Muscle;Nerve Endings;Neurons;Neurotoxins;neurotransmission;novel;novel therapeutics;Oral;Organic Synthesis;Paralysed;Peptide Hydrolases;Peptides;peptidomimetics;Permeability;Persons;Pharmaceutical Preparations;Poison;Population;presynaptic;prevent;Property;Public Health;Readiness;receptor;Reporting;Research;Research Personnel;Respiratory Failure;Route;scaffold;Serotyping;small molecule;SNAP receptor;soluble NSF attachment protein;sound;Source;Structure-Activity Relationship;Synaptic Membranes;Therapeutic;therapeutic lead compound;therapeutic target;Toxin;Training;undergraduate student;weapons;Work;X-Ray Crystallography;Zinc

PROJECT_TITLE: Synthesis and evaluation of peptidomimetics to probe the active site of the botulinum neurotoxin to discover therapeutic leads for the treatment of botulism

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 MMO-D (J1)]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PUBLIC HEALTH RELEVANCE The Training Program in Social Neuroscience Research provides rigorous training in basic and translational research in social behavior as it pertains to neuropsychiatric diseases, and seeks to identify and train a group of highly talented predoctoral students and postdoctoral fellows who will become the next generation of mental health investigators prepared to significantly advance our understanding and the treatment of social behavior deficits in neurodevelopmental and neuropsychiatric diseases. The goal of the program is to provide training through an integrated program of coursework, basic or translational laboratory training, seminars and retreats, teaching opportunities, mentoring, and career development activities to a new generation of creative, rigorous, and independent neuroscientists committed to the field of Social Neuroscience and to improving public health.

PI_NAMEs: MORISHITA, HIROFUMI ;RUSSO, SCOTT JAMES (contact)

PROJECT_TERMS: Neurosciences Research;social neuroscience;Training Programs


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: FORT COLLINS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative The goal of our training program is to create a new generation of biologists with the skills to generate and analyze as well as interpret the complex data produced by modern approaches such as next generation sequencing, live cell imaging and flow cytometry. Our trainees will apply their training in Quantitative Cell & Molecular Biology to study problems related to cancer, infectious disease, microbiomes and development. At the same time, they will receive career guidance and develop transferrable skills to prepare them for leadership roles after graduation.

PI_NAMEs: ARGUESO, JUAN LUCAS  (contact);DOBOS, KAREN MARIE;SLOAN, DANIEL BENJAMIN;WILUSZ, CAROL J

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TITLE: Predoctoral Training in Quantitative Cell & Molecular Biology

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Eating Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Nutrition;Social Determinants of Health

ORG_CITY: LAS VEGAS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: PROJECT NARRATIVE Undergraduate students who experience food insecurity (FI) are at very high risk for eating disorders; however, the specific mechanisms linking the experience of FI to eating behaviors remain largely unknown. The proposed project aims to evaluate a mechanistic model of how daily experiences of FI are associated with 1) problematic eating behaviors, which in turn may amplify FI and eating disorder pathology and 2) poorer academic performance. Such knowledge can influence the development or modification of eating disorder treatments to address the unique concerns of students with FI and promote better health and well-being and increased academic attainment.

PI_NAMEs: CHRISTENSEN PACELLA, KARA ALISE (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Address;Affect;Behavior Disorders;Calories;clinically significant;Compensation;Consumption;Cross-Sectional Studies;Data;Death Rate;design;Development;Dietary Assessment;dietary restriction;Eating Behavior;Eating Disorders;Ecological momentary assessment;Economic Burden;Economic Conditions;Economics;Education;Ethnic Origin;Ethnic Population;Etiology;Evaluation;experience;Feedback;Food;food insecurity;Future;General Population;Generations;Health;Health Disparities Research;health disparity;Healthcare Systems;high risk;Household;Hyperphagia;Individual;innovation;Institution;Intervention;Knowledge;Link;loss of control over eating;Low income;Mediating;Mental disorders;Mental Health;Minority-Serving Institution;Modeling;Modification;Morbidity - disease rate;mortality;Outcome;Pathology;Pathway interactions;Performance;Personal Satisfaction;Persons;physical conditioning;pressure;Probability;Process;psychologic;Public Health;Quality of life;racial minority;racial minority population;Reporting;Research;Research Infrastructure;Research Personnel;Resources;Risk;Scientist;Severities;Shapes;Social Conditions;Students;Symptoms;systematic review;Testing;training opportunity;Treatment Efficacy;undergraduate student;university student;Weight

PROJECT_TITLE: Testing a Dual-Process Mechanistic Model Linking Food Insecurity and Loss-of-Control Eating

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-8 (SU)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Regenerative Medicine

ORG_CITY: WOODS HOLE

ORG_NAME: MARINE BIOLOGICAL LABORATORY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Over the past 25 years, the zebrafish has become one of the most prominent model systems in which to study the genetic, molecular and cellular mechanisms underlying embryonic development, regeneration, and disease. This proposal requests support for an intensive two-week laboratory and lecture course held at the Marine Biological Laboratory (MBL) for advanced graduate students, postdoctoral fellows and independent investigators that focuses on the development and genetics of zebrafish, with special emphasis on early embryogenesis, models of birth defects, and regeneration. In its 24th year, the MBL Zebrafish course is the only course of its kind worldwide, and it consistently receives rave reviews from participants, many of whom consider their experience in the course as instrumental in starting their own zebrafish research program.

PI_NAMEs: HYMAN, LINDA E (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Ablation;Adult;Anatomy;Atmosphere;Basic Science;Behavior;Biological;Biological Models;Body System;career;cell motility;Cell Shape;Cell Transplantation;Cells;Collaborations;Communities;Congenital Abnormality;Course Content;Data;Development;developmental disease;developmental genetics;Disease;disease model;Education;education research;Educational Curriculum;Educational process of instructing;Educational workshop;Embryo;Embryonic Development;Ensure;Environment;Evaluation;Event;Exercise;experience;Faculty;Fishes;fluorescence imaging;Fostering;Funding;Future;gene function;Genes;Genetic;Genetic study;genome editing;genome resource;Goals;graduate student;hands on research;Human;human model;Image;Immunohistochemistry;In Situ Hybridization;Institution;instructor;instrument;International;Investigation;Knowledge;Label;Laboratories;laboratory experience;laboratory experiment;Larva;Learning;lectures;marine;member;Microinjections;Microscopy;Mission;model organism;Modeling;Molecular;Morphogenesis;National Institute of Child Health and Human Development;National Institute of Neurological Disorders and Stroke;Natural regeneration;neural circuit;Neurosciences;next generation;Online Systems;Organism;Organogenesis;pandemic disease;Participant;peer;Postdoctoral Fellow;programs;recruit;Regulator Genes;Reporter Genes;Reproducibility;Request for Proposals;Research;Research Personnel;Research Training;Resolution;response;Scientist;skills;social;Staging;stem cells;Structural Congenital Anomalies;student mentoring;Students;System;Talents;Techniques;Technology;Testing;Time;tissue regeneration;Training;Transgenic Organisms;unconscious bias;Underrepresented Populations;Vertebrates;Visual;Zebrafish;zebrafish development

PROJECT_TITLE: Zebrafish Development and Genetics

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The core mission of the Stanford Neurosciences PhD training program is to foster development of the next generation of world leaders in neuroscience research, training, and outreach. Our program prepares students for careers in neuroscience by giving them tools to ask and answer questions about how the brain functions in health and disease, with vast implications for society ranging from treatments of neural diseases and disorders to implications for technology development, education, law, and the fundamental understanding of how our brains make us who we are. The diversity of research topics and faculty, the availability of novel technologies, the highly collaborative nature of the program, the innovative approach to curriculum, and the central role that students play in all aspects of their training are all unique aspects of the community and culture of the program.

PI_NAMEs: GARDNER, JUSTIN L;MADUKE, MERRITT C (contact)

PROJECT_TITLE: Neuroscience Research Training

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (03)]


ADMINISTERING_IC: DD

IC_NAME: NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES

ORG_CITY: MADISON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: This study will shed light on a wide variety of genetic, prenatal, early-life and family factors that influence the risk for autism spectrum disorder (ASD) and on differences and similarities in the behaviors, abilities, and health of preschoolers with ASD. It will also provide insights into the experiences of adolescents with ASD as they mature. By helping to explain the causes of ASD and how ASD affects children, youth and young adults, this project will contribute to efforts to reduce the risk of ASD and improve the outcomes of affected children.

PI_NAMEs: DURKIN, MAUREEN S (contact)

PROGRAM_OFFICER_NAME: OGUNFUYI, SHAKIRATU BIOLA

PROJECT_TITLE: Component A: Study to Explore Early Development (SEED) Follow up Studies


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

PHR: Project Narrative Utilizing an extensive amount of qualitative and quantitative imaging, clinical, and functional data, we propose to investigate newly developed and novel chest CT scan imaging and spirometric markers to the investigation of lung tissue and airway injury and remodeling, and its evolution over time towards healing and recovery, or to chronic and disabling chronic lung disease. These investigations have the potential to enhance our ability for earlier and more effective detection or treatment, and to prevent disability.

PI_NAMEs: DE LA HOZ, RAFAEL E. (contact)

PROJECT_TITLE: Pulmonary Diseases in WTC Workers: Symptoms, Function, and Chest CT Correlates


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative - SEED Follow-Up This study will shed light on a wide variety of genetic, prenatal, early-life and family factors that influence the risk for autism spectrum disorder (ASD) and on differences and similarities in the behaviors, abilities, and health of preschoolers with ASD. It will also provide insights into the experiences of adolescents with ASD as they mature. By helping to explain the causes of ASD and how ASD affects children, youth and young adults, this project will contribute to efforts to reduce the risk of ASD and improve the outcomes of affected children.

PI_NAMEs: DANIELS, JULIE L (contact)

PROJECT_TITLE: Component A: North Carolina - Advancing Developmental Research using SEED and SEED Follow-up data


ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: As we approach the 20th anniversary of 9/11, the focus of this study is to thoroughly examine the long-term consequences of being exposed to 9/11 as a child, including mental and physical health, adult development, role functioning, relationships, independence and parenting Using our thoroughly characterized ongoing longitudinal, representative cohort of 9/11 directly exposed children, we will now conduct a third wave of physical and psychological assessments and add a thorough examination of adult developmental achievements and challenges. This will result in the largest, longest and most thoroughly studied cohort of 9/11 exposed children, and will give us the knowledge to mitigate their suffering and improve their lives, as well as the lives of children exposed to mass trauma in the future.

PI_NAMEs: HOVEN, CHRISTINA W. (contact)

PROJECT_TITLE: Longitudinal Follow-Up of 9/11 Directly Exposed Children in their Age of Transition: Independence, Occupation and Morbidity


ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Narrative World Trade Center (WTC) responders were exposed to a mix of tiny dust particles as they participated in rescue and recovery efforts at the WTC in the aftermath of 9/11/2001. While all responders were exposed, the Fire Department of the City of New York (FDNY) responders were more intensely exposed to a larger array of inhaled particles. Given the magnitude and scale of events surrounding 9/11 and prior reports of cognitive dysfunction indicative of an underlying neurodegenerative disease, we propose here to examine cognitive symptoms, blood- based biomarkers, and Beta-Amyloid and Tau burden using positron emission tomography (PET) combined with magnetic resonance neuroimaging (MRI) in a group of FDNY responders to compare with work being completed now in the NYPD and Volunteer responders at Stony Brook University as part of an existing NIA-funded study of brain aging.

PI_NAMEs: CLOUSTON, SEAN  (contact);HALL, CHARLES B

PROJECT_TITLE: Cognition and neuropathology in World Trade Center-exposed FDNY, NYPD, and construction worker responders


PHR: Project Narrative As the World Trade Center general responder cohort ages (current median age is 59), the assessment of aging- related syndromes (e.g., falls, functional decline) and implementation of healthy aging interventions become increasingly important. The goals of this study are to: (1) validate a frailty index among the WTC general responder cohort that will allow identification of risk factors that worsen frailty trajectories and predict aging- related outcomes; and (2) implement a pilot multicomponent intervention targeting modifiable risk factors of frailty among WTC responders. This work will enable timely monitoring for frailty and the development of interventions to promote healthy aging and to prevent further clinical decline in this high-risk population.

PI_NAMEs: HUNG, WILLIAM W.,MPH, MD;KO, FRED CHAU-YANG (contact);ORNSTEIN, KATHERINE A

PROJECT_TITLE: Promoting healthy aging among WTC responders: Frailty trajectories and intervention strategies


ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The adverse health effects at the intersection of metabolic syndrome, particulate matter exposure, and pulmonary disease are a global health concern. In the context of our FIREHOUSE cohort, we will i. perform comprehensive and integrative multiOMIC profiling to identify metabolic contributors and biosignatures of disease and its potential therapeutic targets; ii. Determine long-term effectiveness of our multidisciplinary approach to improve health outcomes; iii. validate our observations made in the prior funding period and iv. determine feasibility and need using shared decision making of the technology supported nutritional intervention. This work falls squarely within the purview of the James Zadroga 9/11 Health & Compensation Act.

PI_NAMEs: NOLAN, ANNA  (contact)

PROJECT_TITLE: Metabolomics of World Trade Center-Lung Injury: Biomarker Validation, Longitudinal Assessment and Dietary Intervention


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: The primary goals of the current project are to examine musical rhythm entrainment as a mechanism of healthy social development as well as disruptions thereof in children with autism spectrum disorder (ASD), a condition defined by atypical social interaction. Building on our prior findings demonstrating that infant eye-looking entrains to the rhythmic social cuing of a caregiver during musical interactions, this collaborative project leverages infant- directed singing to examine predictability as a driver of social rhythmic entrainment, including through the use of music and rhythm to enhance predictable delivery of social information delivered during naturalistic developmental behavioral interventions for ASD. This collaborative research will inform understanding of basic mechanistic processes of social entrainment in ASD and will support the development of evidence-based music interventions for social communication in ASD.

PI_NAMEs: JONES, WARREN ;LENSE, MIRIAM  (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Adult;Affect;arm;Attention;Attenuated;autism spectrum disorder;autistic children;Behavior;behavior change;Behavior Therapy;Biological;Blinking;Caregivers;Child;Child Development;Child Health;Cognition;Communication;Cues;Data;Development;Disease;evidence base;Evidence based intervention;Exhibits;experimental study;Eye;Face;Future;Goals;Health;Human Development;Impairment;improved;Individual;individuals with autism spectrum disorder;infancy;Infant;Infant Behavior;insight;Intervention;Investigation;Measures;millisecond;Motion;Music;Music Therapy;Neurodevelopmental Disorder;Outcome;Periodicity;predicting response;Process;Randomized;Research;response biomarker;Role;scaffold;Severities;social;Social Behavior;social communication;Social Development;social engagement;Social Interaction;social interventions;social neuroscience;Structure;Systems Biology;Time;Toddler;Training;Unconscious State;vocalization

PROJECT_TITLE: Musical Rhythm Sensitivity to Scaffold Social  Engagement in Autism Spectrum Disorder


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: WASHINGTON

ORG_NAME: U.S. DEPT/VETS AFFAIRS MEDICAL CENTER

ORG_STATE: DC

PHR: Central nervous system (CNS) stimulants are controlled substances that are associated with a (high) potential for misuse and abuse. They are prescribed for many Veterans with mild TBI, however, little is known about their prescription pattern and safety in this population. The proposed project will fill in this significant knowledge gap by characterizing CNS stimulant prescription pattern in the VA, examining their adverse effects, and developing an explainable machine (deep) learning prediction model for individual-level risk assessment.

PI_NAMEs: AHMED, ALI ;FASELIS, CHARLES J (contact)

PROJECT_TERMS: Accounting;Acute;Address;Adverse effects;Age;Amphetamines;anti-depressive agents;Antipsychotic Agents;associated symptom;Attention deficit hyperactivity disorder;Benzodiazepines;Black Box;Blinded;care seeking;Central Nervous System;Central Nervous System Diseases;Central Nervous System Stimulants;Characteristics;Child;Clinical;Clinical Practice Guideline;cohort;Complex;Computers;Congresses;cost;Data;data registry;Demographic Factors;design;Dextroamphetamine;Diagnosis;Educational Materials;Enrollment;Evaluation;evidence base;explainable machine learning;follow-up;Guidelines;high risk;Homogeneously Staining Region;Hospitalization;Individual;innovation;International Classification of Disease Codes;Knowledge;Long term disability;Machine Learning;machine learning prediction;Measures;medication safety;Methodology;mild traumatic brain injury;military veteran;Modafinil;Modeling;Morbidity - disease rate;mortality;Neurocognitive;Nonpharmacologic Therapy;Outcome;Patients;Pattern;persistent symptom;Pharmaceutical Preparations;Polypharmacy;Population;predictive modeling;prescription stimulants;Provider;Publications;Race;randomized controlled design;Randomized, Controlled Trials;Recommendation;Recording of previous events;Registries;Research Priority;Risk;Risk Assessment;risk prediction model;Risk Reduction;Ritalin;Safety;Screening procedure;sex;Software Tools;Source;Stimulant;stimulant use;Substance Use Disorder;Symptoms;System;TBI Patients;Testing;Time;Traumatic Brain Injury;United States Centers for Medicare and Medicaid Services;Veterans;Work

PROJECT_TITLE: Understanding CNS Stimulant Use and Safety in Veterans with TBI

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE A better understanding of the factors that underpin vulnerability and resilience to develop substance use disorders is critical. The pre-clinical neurobiological studies in this proposal will reveal how early life stress affects resilience to the development of addiction-related behaviors. This proposal leverages emerging technologies that facilitate the delineation of cell-type specific brain molecular signatures predictive of resilience to substance abuse.

PI_NAMEs: BANGASSER, DEBRA A;REINER, BENJAMIN CHARLES;WIMMER, MATHIEU  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: addiction;addiction liability;Address;Affect;associated symptom;Award;Beds;Behavior;Behavioral;Behavioral Model;Biological Assay;Brain;brain cell;Brain region;Caring;Cell Nucleus;cell type;Cells;Chromatin;chromatin remodeling;Data;Data Set;Development;Diagnosis;differential expression;early life adversity;early life stress;Emerging Technologies;endophenotype;Epigenetic Process;epigenome;epigenomics;Exposure to;Female;Foundations;Gene Expression;Genes;Genetic;genome wide association study;genome-wide;Goals;Grant;Heterogeneity;Human;human data;improved;Impulsivity;Individual;Laboratories;male;Maps;Mediating;Mental disorders;Modeling;Molecular;Molecular Profiling;Morphine;Neurobiology;Neurons;Neurosciences;Noise;Nucleus Accumbens;Opioid;opioid epidemic;opioid exposure;opioid therapy;opioid use;opioid use disorder;Pain management;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;postnatal;postnatal period;pre-clinical;predictive signature;Predisposition;pregnant;prenatal stress;Prevention;Preventive measure;Process;programs;promote resilience;Proxy;Publishing;pup;Rattus;Regulation;resilience;Resource-limited setting;Resources;reward circuitry;Rodent;Rodent Model;Role;Self Administration;sex;Shapes;Signal Transduction;single nucleus RNA-sequencing;Stress;stressor;Substance abuse problem;Substance Use Disorder;substance use treatment;Therapeutic;Tissues;tool;transcriptome;transcriptomics;Transposase;Treatment outcome;Withdrawal Symptom

PROJECT_TITLE: Cell-specific epigenetic and transcriptomic signatures of impulsivity and its regulation by stress in the nucleus accumbens

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Genetics

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE Bacterial genes acquired through horizontal transfer are silenced by small histone-like proteins and by the transcription termination factor Rho. Expression of these genes, which are required for bacterial survival under some conditions, depends on accessory proteins that relieve silencing. In this project, we will investigate mechanisms by which Escherichia coli cell envelope biogenesis genes are silenced and activated by RfaH.

PI_NAMEs: ARTSIMOVITCH, IRINA  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Antibiotics;Bacteria;Bacterial Genes;Binding;Biochemical;Biochemistry;Biogenesis;biological adaptation to stress;Biology;cell envelope;Cells;Chromatin;Communities;Complex;Coupling;Data;DNA;DNA-Binding Proteins;DNA-Directed RNA Polymerase;Elongation Factor;Ensure;Environment;Enzymes;Escherichia coli;Exclusion;experimental study;Family;Filament;Food;Funding;Gene Expression;Gene Expression Regulation;gene repression;Gene Silencing;Genes;Genetic;Genetic Transcription;genome-wide;Genomics;Growth;Habitats;Heterochromatin;Histones;Homologous Gene;Hyperactivity;In Vitro;in vivo;in vivo evaluation;insight;Interdisciplinary Study;Life;Maintenance;Mediating;Molecular;Molecular Chaperones;Molecular Conformation;Molecular Genetics;Nature;Nucleoproteins;Nutrient;Operon;paralogous gene;Phylogenetic Analysis;Positioning Attribute;Productivity;promoter;Proteins;Proteomics;Regulation;repaired;Research Personnel;rho;Rho Factor;RNA;RNA chemical synthesis;Source;Stress;Structure;termination factor;tool;Transcription Elongation;Transcription Initiation;transcription termination;Translating;Translations;Travel;Virulence Factors;Work

PROJECT_TITLE: Cellular factors maintaining and reversing silencing of bacterial chromatin

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative  Human health and lifespan depend critically on genetics. Basic research on the principles of genetics can lead to dramatic improvements in the prevention, diagnosis, and treatment of a vast number of human diseases. The proposed program is designed to provide training in genetics research to predoctoral students and to prepare them for leadership in scientific research and research-related careers.

PI_NAMEs: CARLSON, JOHN R;MUZUMDAR, MANDAR DEEPAK (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Genetic;pre-doctoral;Training Programs

PROJECT_TITLE: Predoctoral Training Program in Genetics


PHR: Project Narrative The Chemistry/Biology Interface Training Program (CBITP) at Yale University will provide rigorous, cutting- edge training in chemical biology research to prepare early-career scientists for research and research-related careers in academia, industry, and the non-profit sector. The CBITP is organized around the belief that the rigorous training of diverse individuals with the brightest minds and a deep commitment to probing basic biological mechanisms using chemical approaches will lead to: 1) new discoveries that could open completely new fields; 2) a unique multidisciplinary workforce; and 3) new economic opportunities in the biotech/biopharma space.

PI_NAMEs: CRAWFORD, JASON MICHAEL (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Biology;Chemistry;pre-doctoral;Training

PROJECT_TITLE: Predoctoral Training at the Interface Chemistry and Biology


NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Pluripotency refers to the ability of a cell to generate any adult tissue in the body, and can be recapitulated in different types of pluripotent stem cells (PSCs) in culture. Mechanistic understanding of how pluripotency is regulated in PSCs is important to realize their full potential for regenerative medicine. The proposed project is focused on deciphering the molecular mechanisms regulating newly discovered PSCs in our laboratory that are competent for efficient differentiation into both somatic and germ cell lineages.

PI_NAMEs: WU, JUN  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Adult;Affinity Chromatography;blastocyst;Cell Differentiation process;Cell Lineage;cell type;Cells;Characteristics;Chemicals;Chimera organism;ChIP-seq;Clustered Regularly Interspaced Short Palindromic Repeats;Competence;Derivation procedure;Development;Developmental Biology;Embryo;embryonic stem cell;Epiblast;established cell line;experimental study;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Foundations;Gastrula;Gene Expression Profile;Generations;Genetic;Germ Cells;Goals;Homeodomain Proteins;Human;human induced pluripotent stem cells;implantation;In Situ;In Vitro;in vivo;Infertility;insight;Laboratories;Maintenance;Methods;Modeling;Molecular;Mouse Embryonic Stem Cells;Mus;Names;novel;old mice;Oocytes;Oogonia;Pathway interactions;permissiveness;Phase;Phenotype;Play;pluripotency;Pluripotent Stem Cells;Proteins;Proteomics;regeneration potential;Regenerative Medicine;Regulation;Regulatory Element;Reproductive Biology;Resources;Role;Signal Transduction;Somatic Cell;Specific qualifier value;stem cell model;stem cells;Structure of primordial sex cell;Study models;Testing;Time;Tissues;tool;transcription factor;transcriptome;Transforming Growth Factor beta;Transgenes;Validation

PROJECT_TITLE: Dissect formative pluripotency using cultured pluripotent stem cells

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE. Ineffective resolution of the effects of stress and aging on cellular proteins can lead to formation of plaques, fibrils, and other aggregated species encountered in aging cells, cataract, and neurodegenerative diseases. This project aims to understand how the protein chaperones called small heat shock proteins change in response to physiological, pathophysiological, and chronic stress conditions and how their chaperone capacity is modulated. Focus will be on small heat shock proteins found in tissues of the eye (lens, retina, cornea) that are implicated in three of the most prevalent pathologies leading to blindness worldwide: cataract, diabetic retinopathy, and age-related macular degeneration.

PI_NAMEs: KLEVIT, RACHEL E (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Age related macular degeneration;Aging;Belief;Binding;Blindness;Cataract;Cell Aging;Cells;Cellular Stress;Chimera organism;Chronic stress;Client;Complex;Comprehension;coping;Cornea;crosslink;Crystalline Lens;Crystallins;Data;Deuterium;Development;Diabetic Retinopathy;Disease;Exposure to;Eye;Failure;first responder;Genetic;Genetic Transcription;Goals;Grain;Grant;Health;Heat shock proteins;holistic approach;HSPB1 gene;Human;Hydrogen;Hypoxia;Individual;Injury;Ischemia;Knowledge;lens;lens transparency;Link;Maintenance;Mass Spectrum Analysis;Modeling;Modification;Molecular;Molecular Chaperones;Molecular Conformation;Mutation;N-terminal;Neurodegenerative Disorders;novel;Ocular Pathology;Pathology;Phosphorylation;Physiological;Positioning Attribute;programs;protein aggregation;protein function;protein misfolding;protein structure;Proteins;Resolution;response;Rest;Retina;Smoking;Specificity;Stress;Structure;Surface;tau aggregation;tau Proteins;Techniques;Testing;Tissues;Ultraviolet Rays;unnatural amino acids

PROJECT_TITLE: A Holistic Approach to Understanding Small Heat Shock Protein Mechanism

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Diverse perspectives in biomedical and behavioral research lead to greater innovation and greater recognition of issues that continue to threaten the health, well-being, and inclusion of underrepresented (UR) communities. Consequently, increasing the diversity of biomedical and behavioral research scientists increases our potential to address the most urgent public health challenges, and is critical to the full realization of our national research goals. The proposed UF MARC program would recruit traditionally UR students who are considering a career as a research scientist, place them in mentored research environments with experienced faculty mentors, provide them with an integrated training curriculum to increase their technical and operational skills, and support their wellness and professional development through to their graduation with a BS degree and continuation to a competitive PhD program.

PI_NAMEs: JULIAN, DAVID  (contact);MARTINS, TALLINE

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Address;Artificial Intelligence;Authorship;Bachelor's Degree;Behavioral Research;Biomedical Research;CCL7 gene;cohort;Course Content;Data Science;Degree program;design;Development;disabled students;Doctor of Philosophy;doctoral student;Educational workshop;Engineering;Environment;Ethnic Population;experience;Extramural Activities;faculty mentor;faculty research;Florida;Funding;Geriatric Psychiatry;Goals;graduate student;Graduation Rates;Group Processes;improved;innovation;Machine Learning;matriculation;Measurable;Mental Health;Mentors;Mentorship;Monitor;Motivation;novel;Outcome;Performance;Postdoctoral Fellow;Preparation;programs;Publications;racial population;recruit;Research;Resources;skill acquisition;Students;Training;undergraduate student;United States National Institutes of Health;Universities;Well in self

PROJECT_TITLE: MARC at the University of Florida

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Biotechnology;Chronic Pain;Opioids;Pain Research;Patient Safety

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROPOSAL NARRATIVE There is no guidance available on the concurrent use of opioids and biologics in individuals with autoimmune disease, despite the potential for severe immunosuppression through a pharmacodynamic drug-drug interaction between opioids and biologics. This research proposal assesses the patterns and safety outcomes of concurrent opioids and biologics use in older adults with autoimmune disease. Findings will address a critical research gap around on the safety of concurrent opioid and biologic use and inform clinical practices to optimize treatment strategies for older adults with autoimmune diseases, directly addressing Strategic Goal C of the National Institute on Aging to “…maintain the health, well-being, and function of older adults”.

PI_NAMEs: BUXTON, MEGHAN CUPP (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Address;Adherence;Adverse event;adverse event risk;Affect;Age;age-related disease;aging related;Anti-Inflammatory Agents;Antibiotics;Autoimmune Diseases;Biological;Biological Products;biological research;Biological Response Modifier Therapy;career;Chronic;chronic pain management;clinical practice;Crohn's disease;Data Analyses;Dependence;Development;Diagnosis;disability;Disease;Disease Management;Disease Outcome;Disease Progression;Drug Combinations;Drug Interactions;effective intervention;Elderly;Enrollment;Environment;Epidemiologist;Epidemiology;Exclusion;experience;Female;Gerontology;Goals;Health;Health Care Research;High Prevalence;Hospitalization;Immune system;immunosenescence;Immunosuppression;improved;Individual;Infection;Inflammation;innovation;insight;Interdisciplinary Study;Knowledge;Literature;Lupus;Medicare;Medicine;Mentorship;Methodology;Methods;mortality;Multiple Sclerosis;National Institute on Aging;novel;older adult;Opioid;opioid use;Outcome;Pain;Pain management;painful neuropathy;Patient-Focused Outcomes;Patients;Pattern;Personal Satisfaction;Pharmaceutical Preparations;Pharmacodynamics;Pharmacoepidemiology;Population;prescription opioid;Prevalence;prevent;Principal Investigator;Public Health Schools;Research;Research Personnel;Research Proposals;Rheumatoid Arthritis;Rheumatology;Safety;safety assessment;safety outcomes;Sampling;Services;skills;Symptoms;Testing;Time;Training;Training Activity;treatment optimization;Treatment outcome;treatment strategy;Ulcerative Colitis;United States;Universities;Woman;Work

PROJECT_TITLE: Treating pain in autoimmune disease: concurrent use of opioids and biologic medication

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Arctic;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: PROJECT NARRATIVE American Indians and Alaska Natives rarely participate in research studies on Alzheimer’s disease and related dementias. This is unlikely to change unless effective communication and recruitment strategies for clinical studies are developed. In this research, we assess how American Indians and Alaska Natives seek, process and react to online information sources about Alzheimer’s disease and related dementias, develop a culturally tailored website, and administer a pilot study to evaluate the feasibility of a future effectiveness trial.

PI_NAMEs: BOYD, AMANDA D. (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Acceleration;Adherence;Adult;Affect;Age;aging related;Alaska Native;Alaska Native population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;American Indian Population;American Indians;Asian population;Attention;Behavior;career development;Clinical Research;Clinical Treatment;Clinical Trials;Cognitive;Communication;Communication Methods;Complement;Computers;Consumption;Cultural Sensitivity;Data;Data Collection;design;Development;digital communication;digital technology;Education;effective therapy;effectiveness trial;Elderly;Electromyography;Emotional;Enrollment;experience;Eye Movements;Face;Funding;Future;Galvanic Skin Response;General Population;Goals;Grant;Guidelines;Health;health communication;Health Disparities Research;Health Policy;Healthcare;Heart Rate;human old age (65+);Image;Imagery;information seeking behavior;innovation;Instruction;Internet;Interview;Knowledge;Measures;Mentors;Methods;Minority Participation;Minority Recruitment;National Institute on Aging;Not Hispanic or Latino;novel;Outcome;Participant;Patient Recruitments;Patient Self-Report;Pattern;Persons;Pilot Projects;Population;Population Heterogeneity;Positioning Attribute;preference;Prevalence;preventive intervention;primary outcome;Process;Protocols documentation;Psychophysiology;Questionnaires;Race;Randomized;randomized trial;Randomized, Controlled Trials;Reaction;Reader;Reading;recruit;recruitment science;Reporting;Research;Research Methodology;Research Personnel;research study;Resources;Respondent;response;Scanning;Self Assessment;Shapes;Site;Source;Structure;success;Surveys;Testing;Text;Training;Underserved Population;United States National Institutes of Health;Variant;Visual;visual tracking;web site;willingness;Writing

PROJECT_TITLE: Advancing Alzheimer's Disease Communication and Recruitment Science among American Indians and Alaska Natives

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Infant Mortality;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Unintentional Childhood Injury

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: NARRATIVE Neonatal hypoxic ischemic encephalopathy (HIE) continues to cause significant morbidity and mortality despite introduction of therapeutic hypothermia. Neonates with HIE are often hemodynamically unstable and clinicians have only indirect measures, such as blood pressure, to determine if cerebral blood flow is adequate to meet the brain’s metabolic demands. The overall goal of this renewal is to determine if direct continuous bedside monitoring of cerebral oxygen metabolism and cerebral blood flow with our novel devices has the potential to ensure cerebral blood flow meets metabolic demands; and in future improve outcomes by improving management of hemodynamic stability.

PI_NAMEs: GRANT, PATRICIA ELLEN (contact);LIN, PEI-YI ;SOUL, JANET SUSAN

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Achievement;adverse outcome;Affect;Blood Pressure;Brain;Brain Hypoxia-Ischemia;cerebral autoregulation;cerebral hemodynamics;Cerebrovascular Circulation;Cerebrum;Clinical;cloud based;Cognitive;Cognitive deficits;comparison control;Consensus;Data;design;Devices;Diffuse;Electroencephalography;Ensure;Evolution;flexibility;Frequencies;Funding;Future;Goals;Grant;Guidelines;Health;hemodynamics;Hour;Hypoxic-Ischemic Brain Injury;Impairment;improved;improved outcome;Infant;Infant Development;Infrastructure;Injury;innovation;Investigation;Lead;Live Birth;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Medical;Metabolic;Metabolism;Monitor;Morbidity - disease rate;mortality;natural hypothermia;Neonatal;neonatal encephalopathy;neonatal hypoxic-ischemic brain injury;Neonatal Intensive Care Units;neonatal outcome;neonate;Neuronal Injury;Neurons;neurovascular coupling;novel;Outcome;outcome prediction;Oxygen;Perinatal mortality demographics;prevent;prototype;Risk;secondary analysis;Secondary to;Severities;Spectrum Analysis;success;System;Technology;Therapeutic;Time;tissue oxygenation;treatment guidelines;treatment optimization;trend;Ventilator

PROJECT_TITLE: Neonatal Hypoxic Ischemic Encephalopathy: Potential of Innovative NIRS to Optimize Hypothermia

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is the most common form of dementia in the elderly population, affecting more than 5 million Americans and 15 million people worldwide. The development of effective disease-modifying therapeutics for AD would greatly benefit from in vivo biomarkers, preferentially those that tag the very earliest stages of the disease. It is critical to establish a panel of valid biomarkers for diagnosis and monitoring its progression, or even prevent it by targeting several pharmaceutical candidates. Despite several existing biomarkers for AD, they do not capture the heterogeneity of the disease and more importantly, lack the sensitivity and specificity for early diagnosis. To address this key challenge and knowledge gap, this proposal aims to develop an innovative multi-faceted approach enabled by multiplexed protein quantitation technology and new advancements of MS instrumentation coupled with front-end sample enrichment and separation strategies for improved glycoproteomics and PTM crosstalk analysis. These technological advancements in combination with clinical neuroimaging will accelerate novel AD biomarker discovery and validation. The successful outcome of this research will have broad impact on translational medicine and will have profound impact on the physical and emotional health of millinois of individual patients at risk for this devastating diease.

PI_NAMEs: LI, LINGJUN  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Affinity;Age;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;American;Amyloid beta-Protein;Autopsy;Biochemical Process;bioinformatics tool;Biological Markers;biomarker discovery;biomarker panel;biomarker validation;Blood;Blood Proteins;Blood specimen;blood-based biomarker;Brain;candidate identification;candidate marker;candidate validation;Cause of Death;Cerebrospinal Fluid;Chromatography;Classification;classification algorithm;Clinical;Clinical assessments;clinical practice;Clinical Trials;Cognition;Cognitive;Cohort Studies;cost;Coupled;Data;data acquisition;Defect;Dementia;design;Development;Diagnosis;differential expression;Disease;disease heterogeneity;Disease Progression;Early Diagnosis;Elderly;Emotional;Glycopeptides;Glycoproteins;glycoproteomics;glycosylation;Health;Immunoassay;Impaired cognition;improved;in vivo;Individual;individual patient;innovation;insight;instrumentation;Isotopes;Knowledge;Leucine;machine learning classification;Mass Spectrum Analysis;Measures;meetings;Methods;middle age;mild cognitive impairment;Modality;Monitor;Neurofibrillary Tangles;neuroimaging;novel;Outcomes Research;Pathogenesis;Pathologic;Patient Care;Patients;Peptides;Persons;Pharmacologic Substance;Phase;Phosphopeptides;Population;Post-Translational Protein Processing;potential biomarker;pre-clinical;prevent;protein biomarkers;Proteins;Proteome;Proteomics;Reproducibility;Research;Risk;Sampling;screening;Sensitivity and Specificity;Serum;Source;Specificity;Structure;tau Proteins;Technology;Therapeutic;translational medicine;Treatment Efficacy;United States;Validation

PROJECT_TITLE: DiLeu-enabled multiplexed quantitation for biomarker discovery and validation in Alzheimer’s disease

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE One step to combat health disparities is to increase diversity in the biomedical workforce, including translational scientists. This program will provide a unique opportunity for underrepresented undergraduate students to have hands-on experience performing translational research. In combination with educational activities, students will be given the foundational tools for successful careers in translational science and will enhance the future biomedical workforce.

PI_NAMEs: SANTILLAN, DONNA ANN (contact)

PROGRAM_OFFICER_NAME: KRASNOVA, IRINA N

PROJECT_TERMS: Academic Medical Centers;Access to Information;Admission activity;Advocacy;American;Bioethics;Black race;career;catalyst;Clinical Research;Clinical Sciences;combat;Communication;community based participatory research;Complement;Complex;COVID-19 pandemic;Data Analyses;data management;design;Disparity;disparity reduction;distrust;Education;Educational Activities;Educational Curriculum;Educational Materials;Eligibility Determination;Ensure;equity, diversity, and inclusion;experience;Faculty;Future;Goals;Health;health disparity;Health Occupations;Healthcare;Improve Access;improved;Indigenous;interest;Interview;Iowa;Location;Longterm Follow-up;Manuscripts;marginalization;marginalized population;member;Mentors;Mentorship;next generation;Outcome;people of color;Persons;Population;Program Evaluation;programs;recruit;Reduce health disparities;Reporting;Research;Research Project Grants;resilience;Resources;responsible research conduct;Role;Rural;rural area;rural health disparities;Scholars Program;Science;Self Assessment;Site;skills;social capital;Students;summer program;summer research;System;Testing;tool;Training;Training Programs;translational pipeline;Translational Research;translational scientist;undergraduate student;Universities

PROJECT_TITLE: Beginning and Early Stage Translational (BEST) Researchers


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Epilepsy;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative The proposed research is relevant to public health because developing new quantitative methods to target and test epilepsy surgery in computer models before doing these procedures in the operating room will improve patient outcomes and reduce surgery side effects and costs. In this research we are also working with 15 major epilepsy centers to standardize treatment. For these reasons the proposal is relevant to part of the NIH’s mission to foster fundamental, creative discoveries and innovative research strategies that will ultimately protect and improve human health for the United States’ 3.3 million people with epilepsy.

PI_NAMEs: BASSETT, DANIELLE SMITH;LITT, BRIAN  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Ablation;Acceleration;Adoption;Algorithms;Anatomy;Archives;Biomedical Engineering;Brain Mapping;Brain region;Caring;Clinical;clinical care;clinical practice;clinical translation;Clinical Trials;Code;Collaborations;computational neuroscience;computer code;Computer Models;Computing Methodologies;cost;Creativeness;Data;Data Aggregation;data sharing;Diffuse;Eastern Cooperative Oncology Group;Electrodes;Electroencephalography;Engineering;Ensure;Epilepsy;Excision;Fostering;Foundations;Generations;Goals;Grant;Health;Human;Image;Implant;implantable device;improved;Individual;individual patient;Information Theory;innovation;Intervention;Letters;Machine Learning;Magnetic Resonance Imaging;Manuals;Maps;Measures;Metadata;Methods;Mission;Modeling;Morbidity - disease rate;Multi-Institutional Clinical Trial;network models;neuroimaging;Neurology;neuroregulation;Neurosciences;neurosurgery;novel;open source;Operating Rooms;Operative Surgical Procedures;Outcome;outcome prediction;Patient Care;Patient-Focused Outcomes;Patients;Pennsylvania;Persons;Pharmaceutical Preparations;Phase;Philosophy;Population;predictive tools;Probability;Procedures;prospective;Protocols documentation;Public Health;Quality of Care;Regional Anatomy;Research;Resected;Sampling;Sampling Biases;Sampling Errors;Seizures;side effect;Standardization;Structure;success;Testing;Tissues;Tonic-Clonic Epilepsy;tool;Translating;United States;United States National Institutes of Health;Universities;Validation;virtual;Work

PROJECT_TITLE: Guiding epilepsy surgery using network models and Stereo EEG