NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Lung;Women's Health Research

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Over 90% of breast cancer-related deaths are due to the metastatic relapse of tumors in distant vital organs such as the lung. In the past decade, significant advances in lung metastasis research have revealed intricate tumor-lung microenvironment interactions which are essential for the development of metastatic lung lesions. The studies proposed here will provide novel insights into the poorly understood lung microenvironment at the pre-metastatic stage of breast cancer progression, and establish a foundation for the development of innovative targeting strategies to prevent and cure lung metastases in breast cancer.

PI_NAMEs: REN, GUANGWEN  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Ablation;Acceleration;Blood;Bone Marrow;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Model;breast cancer progression;Cancer Etiology;Cell Culture System;Cells;Cessation of life;Data Set;Dendritic Cells;Development;Disease;Distant;Endowment;Extravasation;Foundations;Genes;genetic manipulation;Genetic Transcription;Genetically Engineered Mouse;Goals;Human;Immune checkpoint inhibitor;immunoregulation;implantation;in vivo;Individual;Infiltration;innovation;insight;knockout gene;Knockout Mice;Lung;lung lesion;Lung Neoplasms;lymphatic vessel;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Mesenchymal;Metastatic Neoplasm to the Lung;Modeling;monocyte;mouse model;Mouse Strains;Mus;Myeloid Cells;Neoplasm Metastasis;neoplastic cell;neutrophil;novel;novel strategies;novel therapeutic intervention;Organ;orthotopic breast cancer;Patients;Play;Population;Pre-Clinical Model;Preparation;prevent;Prevention;Primary Neoplasm;Proliferating;pulmonary function;recruit;Relapse;Reporting;Research;Role;Site;Soil;Solid;Solid Neoplasm;Stream;Stromal Cells;System;Testing;theories;therapeutic target;Tissues;transcriptome;transcriptome sequencing;treatment strategy;tumor;Tumor Immunity;Tumor-Derived;tumor-immune system interactions

PROJECT_TITLE: Lung Resident Mesenchymal Cells in the Pre-Metastatic Niche Formation

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ADMINISTERING_IC: EB

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Networking and Information Technology R&D (NITRD)

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Modern magnetic resonance spectroscopy (MRS) experiments can measure various physical properties of chemicals in the brain. Current computer modeling tools are inadequate to extract the information that such experiments can deliver, and this project seeks to develop new modeling and quantification tools that will be freely accessible to the MRS community.

PI_NAMEs: OELTZSCHNER, GEORG  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Address;Adoption;Algorithms;Behavior;Biochemical;biophysical properties;Brain;candidate marker;cell type;chemical property;cloud based;Cloud Computing;Code;Communities;Computer Models;Concentration measurement;Coupled;Data;density;design;Diffusion;diffusion weighted;Elements;Equipment;Event;experimental study;Fingerprint;flexibility;Freedom;Grant;High Performance Computing;High-dimensional Modeling;Human;improved;in vivo;in vivo magnetic resonance spectroscopy;Individual;innovation;Internet;Knowledge;Linear Models;Link;Magnetic Resonance Spectroscopy;Measures;Metabolic;Methods;model design;Modeling;Modernization;neurochemistry;novel;open source;Participant;Pathology;pharmacologic;Phase;physical property;Physiologic pulse;Physiological;potential biomarker;Property;Recovery;Relaxation;Resolution;response;Running;Series;Signal Transduction;Spectrum Analysis;Stimulus;Techniques;Testing;Time;Tissues;tool;Translating;user-friendly

PROJECT_TITLE: General Linear Modeling For Magnetic Resonance Spectroscopy

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Studies proposed will determine the dysregulated epigenome and transcriptome, as well as lethal activity of BET protein degrader- and CDK9 inhibitor-based combinations, in patient-derived, genomically-profiled, post- myeloproliferative neoplasms (MPN) secondary (s) AML blast progenitor cells (BPCs). Additionally, these studies will determine in vivo activity of the BETP-PROTAC-based combinations against JAK-kinase inhibitor-, BET inhibitor- and CDK9 inhibitor-persister/resistant post-MPN sAML BPCs.

PI_NAMEs: BHALLA, KAPIL  (contact);VERSTOVSEK, SRDAN

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Acetylation;antagonist;Apoptotic;ATAC-seq;Attenuated;BCL2 gene;BCL2L1 gene;Binding;Binding Sites;Bromodomain;Bromodomains and extra-terminal domain inhibitor;c-myc Genes;C-terminal;calreticulin;Catalytic Domain;CDK9 Protein Kinase;Cell Culture Techniques;cell growth;Cell Line;Cell Survival;chemotherapy;ChIP-seq;Chromatin;Chromatin Remodeling Factor;Clinical;cyclin T1;Cyclin-Dependent Kinase Inhibitor;Cyclin-Dependent Kinases;Dependence;Disease Progression;DNA Polymerase II;DNA Sequence Alteration;DNMT3a;Elements;Enhancers;Enzymes;Epigenetic Process;epigenetic regulation;epigenome;Evaluation;Exhibits;EZH2 gene;Family member;Genes;Genetic Transcription;genomic profiles;Growth;Hematopoietic stem cells;Histones;improved;In Vitro;in vivo;Induction of Apoptosis;inhibitor;JAK1 gene;JAK2 gene;Janus kinase;Lysine;MCL1 gene;Mediating;Mediator;Messenger RNA;mimetics;Mutation;Myelofibrosis;Myeloproliferative disease;negative elongation factor;Neoplasm Metastasis;NF-kappa B;novel;Oncogenes;Outcome;Patients;Phenotype;Phosphorylation;PIM1 gene;Positive Transcriptional Elongation Factor B;pre-clinical;preclinical efficacy;Predisposition;Productivity;promoter;Protac;protein expression;Protein Family;Proteins;Reader;recruit;Refractory;RELA gene;Repression;Resistance;resistance mechanism;RNA;RUNX1 gene;Secondary acute myeloid leukemia;Serine;Signal Transduction;SRSF2 gene;STAT3 gene;stem cells;Techniques;Testing;Therapeutic;Time;TP53 gene;Transcript;transcription factor;transcriptome;transcriptome sequencing;Xenograft Model

PROJECT_TITLE: Targeting dysregulated transcriptome as therapy for post-myeloproliferative neoplasm (MPN) sAML

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: HADLEY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: Project Narrative: Preschool-age children (3-5 years) from low socioeconomic environments have lower performance in cognition (executive functions, memory) and gross motor skills, which places them at an increased risk for poor academic achievement and low physical activity levels. This proposal will examine the implementation and preliminary efficacy of a provider taught gross motor skill-based physical activity intervention on cognition in children from low socioeconomic environments. Neural changes that occur with improved gross motor skills may have beneficial effects on cognition as well as gross motor skills and, therefore, may provide a feasible approach to support cognitive and motor development of children from low socioeconomic environments.

PI_NAMEs: ALHASSAN, SOFIYA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Academic achievement;active lifestyle;Adherence;Adolescence;Age;age group;American;Area;Attention;Behavior;behavioral outcome;Black race;Brain;Brain region;Caring;Cerebellum;Child;Child Care;Child Development;Cognition;Cognitive;cognitive development;cognitive enhancement;cognitive function;cognitive task;Complex;Control Groups;Corpus striatum structure;Data;design;Development;Disadvantaged;dosage;early childhood;Early Intervention;Education;Educational process of instructing;Environment;Episodic memory;Ethnic Origin;executive function;exercise intervention;frontal lobe;Future;Guidelines;Habits;Head Start Program;Health;healthy lifestyle;high reward;high risk;Hippocampus;implementation outcomes;implementation process;improved;inattention;Informal Social Control;Intervention;Latinx;Learning;Longitudinal Studies;low socioeconomic status;maladaptive behavior;Massachusetts;Memory;Mental Health;Modeling;moderate-to-vigorous physical activity;Motor;motor skill learning;Motor Skills;Movement;Nature;neural;neural circuit;neurodevelopment;Nursery Schools;Outcome;Performance;Phase;Physical activity;Policies;Population;Positioning Attribute;Prefrontal Cortex;Preschool Child;primary outcome;process evaluation;Provider;Race;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Research Design;research study;Risk;Role;Sampling Studies;School-Age Population;secondary outcome;Short-Term Memory;skill acquisition;skills;socioeconomic disadvantage;socioeconomics;System;teacher;Testing;Time;Trainers Training;Training;Treatment Efficacy;Work

PROJECT_TITLE: Feasibility and fidelity of a gross motor-based physical activity intervention on cognitive variables in preschool-age children from low socioeconomic backgrounds

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Conditions Affecting the Embryonic and Fetal Periods;Disability Research;Endocannabinoid System Research;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Intellectual and Developmental Disabilities (IDD);Natural Products;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: COLLEGE STATION

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE Simultaneous alcohol and cannabis consumption is an increasingly common form of drug use among young adults of child-bearing age, and likely contributes to higher rates of polysubstance exposure for fetuses developing in-utero. Prenatal drug exposure not only contributes to lifelong health risks and a shorter lifespan, but also imposes economic and psychosocial burdens on society. By investigating the specific genetic and behavioral consequences of this combined drug exposure, we aim to inform targeted treatments for individuals with a history of prenatal polysubstance exposure and improve their overall quality of life.

PI_NAMEs: ROUZER, SIARA  (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: 2-arachidonylglycerol;Actins;Acute;Address;adverse outcome;Age;Alcohol consumption;alcohol exposure;alcohol seeking behavior;Alcohols;anandamide;Applications Grants;ATAC-seq;Behavior;Behavioral;Behavioral Assay;behavioral impairment;behavioral phenotyping;Biological Assay;brain tissue;Cannabinoids;Cannabis;career;Child;child bearing;Clinical assessments;CNR1 gene;Code;Consumption;Corpus striatum structure;Cytoskeletal Proteins;Data;design;Development;developmental disease;disability;Drug Combinations;Drug Exposure;drug seeking behavior;Drug usage;Economics;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;Environment;Enzyme-Linked Immunosorbent Assay;Ethanol;Exhibits;experimental study;Exposure to;Female;fetal;Fetal Alcohol Exposure;Fetal Development;fetal drug exposure;fetal marijuana exposure;field study;Future;gene network;Genes;Genetic;Glutamates;Goals;Growth;Health;Human;Hyperactivity;Impairment;improved;in utero;Individual;Inhalation;Knowledge;life span;Ligands;Link;Literature;locomotor deficit;Long-Term Depression;male;marijuana user;Mentors;Mentorship;Messenger RNA;Modification;Mothers;Motor;motor deficit;motor disorder;motor impairment;Mus;nerve stem cell;neural circuit;neurodevelopment;neurogenesis;Neurologic;Neurons;neurophysiology;Nuclear;offspring;Output;Patient Self-Report;Pharmaceutical Preparations;Physiological;pre-clinical;Pre-Clinical Model;preference;Pregnancy;prenatal;prenatal exposure;presynaptic;protein expression;Proteins;Proteomics;psychosocial;Psychotropic Drugs;Quality of life;receptor;Recording of previous events;Records;Research;Research Personnel;Risk;Self Administration;sex;sex as a biological variable;Signal Pathway;social stigma;Societies;Source;Synapses;Synaptic plasticity;Synaptic Transmission;Synaptosomes;synthetic cannabinoid;targeted treatment;Technical Expertise;Teratology;Testing;Therapeutic;Therapeutic Intervention;Training;transcriptome sequencing;young adult

PROJECT_TITLE: Simultaneous prenatal alcohol and cannabinoid exposure & offspring corticostriatal neurocircuitry


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Mental Health;Neurosciences;Pain Research;Sleep Research

ORG_CITY: TALLAHASSEE

ORG_DEPT: CHEMISTRY

ORG_NAME: FLORIDA AGRICULTURAL AND MECHANICAL UNIV

ORG_STATE: FL

PHR: Project Narrative According to the American Sleep Association, 50-70 million US adults have a sleep disorder, insomnia being the most common specific sleep disorder with 30% of adults reporting short term issues and 10% reporting chronic insomnia. Meanwhile, 37.9% US adults reported unintentionally falling asleep during the day at least once in the preceding month, while 4.7% reported nodding off or falling asleep while driving at least once in the preceding month. Given that drowsy driving is responsible for 1,550 fatalities and 40,000 nonfatal injuries annually in the US, this remains a serious public health crisis requiring serious attention. Meanwhile, neuropathic pain estimated in the general population to range between 3% and 17%, lacks an effective treatment as most of the available treatments have only moderate efficacy and present significant side effects that limit their use. Therefore, other therapeutic approaches, such as the development of biased 5- HT7R agonists which have been demonstrated to have therapeutic advantages for treating certain sleep disorders and neuropathic pain and are proposed in this application, are urgently needed.

PI_NAMEs: ABLORDEPPEY, SETH Y (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Addictive Behavior;Address;Adult;Affinity;Agonist;Alcohol abuse;American;Amino Acids;antagonist;Attention;autism spectrum disorder;Automobile Driving;Behavioral;Behavioral inhibition;beta-arrestin;Biological Availability;Brain;Cardiovascular system;Central Nervous System Diseases;Characteristics;Chronic Insomnia;Circadian Rhythms;Cognition;Cognitive;Coupled;design;Desire for food;Development;Disease;Docking;Drowsy Driving;Drug abuse;drug discovery;Drug Kinetics;effective therapy;Electroencephalography;Electrons;Epilepsy;Evaluation;falls;Family;Fragile X Syndrome;Functional disorder;General Population;Goals;GTP-Binding Proteins;Homology Modeling;Hormonal Change;Human;hydrophilicity;Hydrophobicity;Hypothalamic structure;improved;in vivo;in vivo evaluation;Incubated;Injury;Isoenzymes;Lead;Learning;Ligands;Liver Microsomes;Locomotion;member;Memory;Mental Depression;Metabolic;Microsomes;Migraine;Molecular Conformation;Moods;Motor;mouse model;New Agents;non rapid eye movement;Pain;Pain Threshold;painful neuropathy;Pathology;Penetration;Permeability;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physiologic Thermoregulation;Play;Population;pre-clinical;Predisposition;Property;Psychophysiology;Public Health;receptor;Recovery;recruit;REM Sleep;Reporting;Role;screening;Selection Bias;Sequence Homology;serotonin 7 receptor;serotonin receptor;side effect;Signal Pathway;Signal Transduction;Sleep;Sleep Architecture;Sleep Disorders;sleep pattern;Sleeplessness;System;Testing;Tetrahydroisoquinolines;Thalamic structure;Therapeutic;Toxic effect;X-Ray Crystallography

PROJECT_TITLE: Discovery of a High Affinity, Selective and β-arrestin Biased 5-HT7R Agonist


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer

ORG_CITY: LAS CRUCES

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

ORG_STATE: NM

PHR: Project Narrative Anti-mitotic drugs have been used as cancer chemotherapeutics for decades. However, our understanding of cellular responses to mitotic delay is incomplete, possibly precluding the use of less toxic approaches. In this proposal, we will employ a combination of biochemical and live cell imaging approaches to examine how a signaling pathway that regulates growth, survival and metabolism determines the fate of cells arrested in mitosis.

PI_NAMEs: SHUSTER, CHARLES BRADLEY (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: 4D Imaging;Acceleration;Adjuvant Therapy;Antimitotic Agents;Apoptosis;Apoptotic;BCL2 gene;Biochemical;Biosensor;cancer cell;Cancer cell line;cancer therapy;cell behavior;Cell Cycle;Cell Death;Cell division;Cell Line;Cell Survival;Cells;Centrioles;chemotherapy;Chromosome Segregation;Clinic;Cytoprotection;Data;Dependence;drug resistance development;Exhibits;Failure;Family;Flow Cytometry;Foundations;Future;Goals;graduate student;Growth;Hela Cells;Heterogeneity;Hormones;Image;imaging approach;Individual;inhibitor;insight;Jordan;Kinesin;Kinetics;Laboratories;live cell imaging;Malignant Neoplasms;MCL1 gene;member;Metabolism;Microscopy;Microtubules;Mitosis;Mitotic;Mitotic spindle;Molecular;Molecular Motors;mTOR Signaling Pathway;neoplastic cell;Normal Cell;Pathway interactions;Peripheral Nervous System Diseases;Pharmaceutical Preparations;Phosphotransferases;population based;Proliferating;Protein Inhibition;Proteins;Reagent;Regulation;Regulatory Pathway;Resolution;response;Role;side effect;Signal Pathway;Signal Transduction;Structure;taxane;Therapeutic;TP53 gene;training opportunity;translational study;tumor;undergraduate student;Vinblastine;Vinca Alkaloids;Western Blotting;Work

PROJECT_TITLE: Parameters that determine cell fate during mitotic arrest


ADMINISTERING_IC: NS

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative  Using intracranial recording in humans undergoing epilepsy surgery, we study how prefrontal cortex dependent brain networks support attention, memory, learning and interpersonal communication. Prefrontal dysfunction is linked to a host of disabling neurological, developmental and psychiatric. This work is core to the NIH mission providing insights into prefrontal control of human behavior with implications for the understanding of normal cognition applicable to the diagnosis and treatment of clinical disorders.

PI_NAMEs: KNIGHT, ROBERT THOMAS (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;Animals;Anterior;Area;Attention;Behavior;Behavioral;Brain;clinical research site;Clinical Treatment;Cognition;cognitive function;cognitive load;Communication;Coupling;Data;Deceleration;Development;developmental disease;Diagnosis;Disabling;Disease;Electroencephalography;Environment;Epilepsy;Etiology;Event;Expectancy;expectation;Feedback;flexibility;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Gambling;Goals;Hippocampus;Human;Image;Impairment;improved;indexing;Individual;insight;Insula of Reil;Knowledge;Lateral;Learning;Link;Literature;Location;Measures;Memory;Mental disorders;Methods;Mission;Motivation;Nervous System Disorder;neural;neural network;Neurologic;neurophysiology;Neuropsychology;non-verbal;Nonlinear Dynamics;Nonverbal Communication;novel;Operative Surgical Procedures;Outcome;Outcome Measure;Parietal Lobe;patient engagement;Patients;Periodicity;Personal Communication;Persons;Phase;Physiology;Play;predictive modeling;Prefrontal Cortex;Psychological reinforcement;Reporting;Research;Reversal Learning;Rewards;Role;Sampling;satisfaction;Sensory;Shapes;Short-Term Memory;Site;social communication;Stimulus;Structure;success;support network;Testing;Texture;transmission process;Uncertainty;United States National Institutes of Health;Update;Work

PROJECT_TITLE: Attention, Orientation and the Human Prefrontal Cortex

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dental, Oral, and Craniofacial Disease;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: In mood disorders, such as depression or schizophrenia, patients may lose positive hedonic capacity for normal pleasures in life, or develop pathologically excessive negative affective reactions, with devastating consequences for their well-being and psychological function. The proposed research will identify how brain circuitry generates positive hedonic ‘liking’ reactions to pleasant stimuli, and how pathological dysfunctions in those hedonic brain mechanisms causes excessive negative dysphoric reactions. Better understanding of how brain circuitry generates positive hedonic ‘liking’, and how neural dysfunction in that circuitry causes intense negative dysphoria, will help lead eventually to improved science-based treatments for depression and other mood disorders.

PI_NAMEs: BERRIDGE, KENT C. (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Adult;Affect;Affective;affective neuroscience;Anatomy;Anhedonia;Anxiety;Basic Science;Bipolar Disorder;Brain;brain circuitry;Code;Development;Disease;Dopamine;dysphoria;Electrodes;Electrophysiology (science);Event;Fright;Functional disorder;Future;gain of function;gamma-Aminobutyric Acid;Globus Pallidus;Goals;hedonic;Human;improved;Infant;insight;Insula of Reil;Lead;Learning;Life;Major Depressive Disorder;Maps;Measures;Mental Depression;Microinjections;Monkeys;Mood Disorders;Morphologic artifacts;negative affect;Negative Valence;neural;neural circuit;neural stimulation;neurochemistry;neuromechanism;Neuronal Dysfunction;Neurons;Nucleus Accumbens;Opioid agonist;optogenetics;orofacial;Pathologic;Patients;Personal Satisfaction;Pharmaceutical Preparations;Photometry;pleasure;Pongidae;prevent;psychologic;Rattus;Reaction;recruit;Research;Rewards;Role;Schizophrenia;Science;Site;Stimulus;Structure;Taste Perception;Techniques;Testing;Therapeutic;Uncertainty;Work

PROJECT_TITLE: Affective neuroscience of taste reactivity

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Center Overview - Project Narrative Gastrointestinal diseases place a tremendous burden on US and South Carolina healthcare. The vision for the Medical University of South Carolina (MUSC) Digestive Disease Research Core Center (DDRCC) is to improve gastrointestinal health by providing support for existing digestive and liver disease research at MUSC via development of new opportunities for collaboration and research programs. The MUSC DDRCC Biomedical Research Cores (Analytical Cell Models, Advanced Imaging, and Proteomics), Clinical Component, and Pilot & Feasibility and Enrichment Programs will create a multifaceted foundation that will support this mission.

PI_NAMEs: ROCKEY, DON C. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Acceleration;Area;Award;base;Basic Science;Biology;Biomedical Research;career development;cell injury;Cell model;Cells;chronic pancreatitis;Clinical;Clinical Research;Clinical Sciences;Collaborations;Colon;Core Facility;Curiosities;Dedications;design;Development;Digestive System Disorders;Disease;driving force;Ensure;Esophagitis;Esophagus;Evaluation;Fibrosis;flexibility;Fostering;Foundations;Functional disorder;Funding;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal tract structure;Goals;Health;Healthcare;Hepatocyte;human disease;human model;Image;imaging capabilities;Imaging Techniques;improved;Inflammation;Inflammatory Bowel Diseases;Injury;innovation;Institution;instrumentation;Investigation;Investments;Leadership;Liver;Liver diseases;liver injury;Malignant Neoplasms;mass spectrometric imaging;Medical;member;Mentorship;Mission;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;novel;novel therapeutics;Organ;organ injury;Pancreas;Participant;Pathogenesis;Patient-Focused Outcomes;Patients;Performance;process improvement;programs;Proteomics;Research;Research Infrastructure;Research Personnel;research study;Resources;Scholarship;Science;Scientific Inquiry;Small Intestines;South Carolina;Stomach;Structure;success;Technology;tissue culture;Tissues;Translating;Translational Research;Universities;Vision;Work

PROJECT_TITLE: MUSC Digestive Disease Research Core Center


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Liver Disease

PROJECT_TERMS: Accountability;Advisory Committees;Basic Science;Biomedical Research;Clinical;Clinical Research;Collaborations;Communication;Digestive System Disorders;Disease;Electronic Mail;Ensure;Evaluation;Fostering;Funding;improved;Infrastructure;innovation;Institution;Leadership;Liver diseases;Medical;member;Mentors;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Newsletter;novel;operation;Oral;Patients;Peer Review;posters;Principal Investigator;Program Evaluation;programs;Recommendation;recruit;Reporting;Research;Research Personnel;Research Support;Resources;Scheme;Scientist;Series;South Carolina;Teacher Professional Development;Therapeutic;Translational Research;United States National Institutes of Health;Universities;web site

PROJECT_TITLE: Admin Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Infant Mortality;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Over the past 22 years as an active member of the Maternal Fetal Medicine Unit (MFMU), the University of North Carolina (UNC) MFMU has proven its commitment by conducting clinical trials with efficiency, excellent subject recruitment and retention, and high data quality. Our solid infrastructure, large diverse patient population, and experienced, committed team members will ensure our success in the upcoming cycle In this proposal we describe our plans to continue our substantive contribution to the research in the MFMU Network by drawing on strengths that are directly aligned to support the MFMU Congressional and public health goals.

PI_NAMEs: THORP, JOHN M (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Affect;Area;cardiovascular stress test;Cessation of life;Clinical;clinical care;clinical center;Clinical Research;clinical research site;Community Networks;Conduct Clinical Trials;Congresses;data quality;Dedications;design;Development;Diagnosis;Discipline of obstetrics;Disease;Disparity;effective therapy;Enrollment;Ensure;Environmental Hazards;Environmental Health;Environmental Science;Epidemiology;Ethnic Origin;evidence base;experience;Fetal Mortality Statistics;flexibility;follow-up;Funding;Future;Goals;hazard;Health;health goals;Heart Diseases;high risk;Hospitals;Human Resources;improved;Individual;Infant;Infant Mortality;Infrastructure;innovation;Lactation;long-term sequelae;maternal morbidity;Maternal Mortality;Maternal-Fetal Medicine Units Network;medical complication;member;Mental disorders;Mission;Morbidity - disease rate;mortality;Mothers;Multi-site clinical study;National Institute of Child Health and Human Development;Neonatal;neonatal morbidity;Neonatal Mortality;North Carolina;novel;obstetric care;obstetrical complication;offspring;Outcome;pandemic disease;Participant;patient population;Perinatal;perinatal health;Persons;Phase;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy Rate;pregnant;premature;Premature Birth;prevent;Prevention program;programs;Public Health;Publications;Race;recruit;Research;Research Proposals;Resources;Risk;Role;Site;skills;socioeconomics;Solid;Substance abuse problem;Substance Use Disorder;success;Survivors;System;Therapeutic;therapeutic evaluation;Translational Research;Universities;Vulnerable Populations

PROJECT_TITLE: UNC MFMU: Advancing Perinatal Health via Definitive, Multi-Site Clinical Studies


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

PROJECT_TERMS: Area;Award;Basic Science;bench to bedside;Biomedical Research;catalyst;Cellular biology;Clinical Investigator;Clinical Research;Collaborations;Communication;Communities;Development;Digestive System Disorders;Doctor of Philosophy;Education;Educational workshop;forging;Fostering;Gastroenterology;Goals;Hepatology;Institution;inter-institutional;Interdisciplinary Communication;Interdisciplinary Study;interest;International;life-long learning;Liver diseases;Medical;member;Mission;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;Oral;posters;Process;programs;recruit;regenerative cell;Regenerative Medicine;Research;research data dissemination;Research Personnel;Scientist;Series;South Carolina;success;Translational Research;translational scientist;Travel;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Enrichment Program


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;Liver Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: DUNCAN, STEPHEN A (contact)

PROJECT_TERMS: Adopted;Affect;analytical tool;Animal Model;Cell Culture Techniques;Cell Differentiation process;Cell Line;Cell Maintenance;Cell model;Cell Separation;Cells;cholangiocyte;CRISPR/Cas technology;Cytometry;differentiation protocol;Digestive System Disorders;DNA Sequence Alteration;Ensure;established cell line;Evaluation;experience;Flow Cytometry;Gastrointestinal tract structure;Generations;Genetic Variation;genome editing;Genome engineering;Goals;Hepatocyte;Human;human model;induced pluripotent stem cell;Infrastructure;injured;Laboratories;Liver;Liver diseases;Medical;medical schools;member;Modeling;Mutate;Mutation;new technology;Organoids;Pathogenesis;Patients;Pluripotent Stem Cells;Procedures;Production;professor;programs;Protocols documentation;Reagent;Research;Research Personnel;Rodent;Running;South Carolina;stem cell biology;Technology;Testing;tissue culture;Tissues;tool;Training;Universities;Update;Wisconsin

PROJECT_TITLE: Analytical Cell Models Core


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: WASHINGTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE The results from MFMU Network studies can potentially benefit pregnant individuals and their children worldwide, by finding methods to screen for problems in pregnancy, treatments that reduce complications in pregnancy, and finding ways to help lessen the problem of babies being born too early. Studies will also determine whether treatments are safe to use when breastfeeding.

PI_NAMEs: CLIFTON, REBECCA GERSNOVIEZ (contact)

PROJECT_TERMS: Academic Medical Centers;Address;Adverse event;Agreement;Award;Biometry;Breast Feeding;Budgets;Certification;Child;Clinical;clinical center;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Cohort Studies;Collaborations;Communication;Communities;community engagement;Data;Data Analyses;Data Coordinating Center;Data Management Resources;data quality;data resource;Data Set;data sharing;design;Devices;Discipline of obstetrics;Education;Ensure;Epidemiology;Equipment;experience;Fetal Growth;Fetal Reduction;flexibility;Funding;Goals;Health Policy;high standard;improved;Individual;infant morbidity;infant morbidity/mortality;Informed Consent;Infrastructure;Institutional Review Boards;International;Laboratories;Lactation;Manuals;Manuscripts;maternal morbidity;Maternal Mortality;Maternal-fetal medicine;Maternal-Fetal Medicine Units Network;meetings;Mentorship;Methods;Mission;Monitor;Multi-Institutional Clinical Trial;Multicenter Studies;National Institute of Child Health and Human Development;Neonatology;Network Infrastructure;Nurses;Observational Study;obstetric care;Obstetric pharmacology;Online Systems;operation;Outcome;Participant;perinatal medicine;Persons;Pharmaceutical Preparations;Policies;Pregnancy;pregnancy health;pregnant;Premature Birth;Preparation;Privatization;Procedures;Productivity;Protocols documentation;Publications;Publishing;Qualifying;Quality Control;Randomized;randomized trial;Reading;Reporting;Reproducibility;Research Design;Research Personnel;research study;Resource Sharing;Resources;Running;Safety;Sample Size;Science;Secure;Site;Site Visit;Statistical Data Interpretation;Structure;Therapeutic;Training;United States Food and Drug Administration;United States National Institutes of Health;Universities;user-friendly;Validation;virtual;Washington;web site;Work;working group

PROJECT_TITLE: NICHD Maternal-Fetal Medicine Units (MFMU) Network: Data CoordinatingCenter


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Digestive Diseases;Liver Disease

PI_NAMEs: LEMASTERS, JOHN J (contact)

PROJECT_TERMS: Address;Animals;Apoptosis;Applications Grants;Biological Sciences;Biology;Cell Membrane Permeability;Cell Survival;Cells;cellular imaging;Clinical;Communities;Computer Workstations;Consultations;Data;Data Analyses;Detection;Development;Digestive System Disorders;digital imaging;Education;Educational workshop;electrical potential;Equipment;fluorescence microscope;Fluorescence Resonance Energy Transfer;Fluorescent Probes;fluorophore;Gases;gastrointestinal;Gene Expression;Generations;Goals;Hepatocyte;high resolution imaging;histological image;histological slides;Image;image processing;imaging approach;imaging system;Imaging Techniques;Imaging technology;Immersion;immunocytochemistry;innovation;instrumentation;intravital imaging;intravital microscopy;Ions;Journals;Leadership;Leukocytes;light microscopy;liquid crystal polymer;Liver;Liver diseases;Medical;meetings;member;Mentors;method development;Methods;Microcirculation;Microscope;microscopic imaging;Microscopy;Mitochondria;Molecular;molecular imaging;Monitor;multi-photon;multiphoton microscopy;multiplexed imaging;Necrosis;new technology;next generation;novel;optical imaging;Optics;Organism;Pathology;pathology imaging;Permeability;Phase;Preparation;protein distribution;Proteins;pyridine nucleotide;quasar;Reporter;Research;Research Personnel;Research Proposals;Resource Sharing;Resources;Scanning;second harmonic;Services;Silicone Oils;Slide;South Carolina;Specimen;submicron;success;superresolution imaging;superresolution microscopy;System;Techniques;Technology;Temperature;Three-Dimensional Imaging;Tissue imaging;Tissues;Training;Training Activity;ultra high resolution;Universities;Water;Work

PROJECT_TITLE: Advanced Imaging Core


ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE There is an urgent need to develop novel therapies in small cell lung cancer (SCLC), a disease for which treatment has stagnated for three decades. We previously discovered that targeting replication stress response (RSR) proteins is a therapeutic opportunity in SCLC. We will (1) characterize the cell-intrinsic and immune- related changes following RSR exacerbation, and (2) develop combinatorial approaches of RSR inhibitors with immune checkpoint blockade to develop potentially revolutionary personalized immunotherapies for SCLC.

PI_NAMEs: SEN, TRIPARNA  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Accounting;adaptive immunity;Affect;anti-cancer research;anti-PD-L1;anti-PD-L1 therapy;anti-tumor immune response;Antigen Presentation;Antitumor Response;Bioinformatics;biological adaptation to stress;Biological Markers;Biology;cancer diagnosis;Cancer Model;Cancer Patient;cancer subtypes;CD8B1 gene;Cell Line;Cells;Cessation of life;CHEK1 gene;chemotherapy;Clinic;Clinical;clinical development;Combination immunotherapy;combinatorial;cytotoxic;Cytotoxic T-Lymphocytes;Development;Disease;DNA Damage;exhaust;FDA approved;FOXP3 gene;Genetic;Genetically Engineered Mouse;Genomic Instability;glycogen synthase kinase 3 beta;glycosylation;Goals;Human Engineering;Immune;immune activation;immune checkpoint blockade;Immune Evasion;Immune response;Immune signaling;Immuno-Chemotherapy;Immunocompetent;immunogenic;immunogenicity;Immunologic Markers;Immunologics;Immunology;Immunooncology;immunoregulation;immunosuppressed;Immunotherapy;improved;in vivo;in vivo Model;Infiltration;inhibitor;innate immune pathways;Innate Immune Response;Interferons;knock-down;Knowledge;Link;Malignant neoplasm of lung;Mediating;Minority;Mission;Molecular;mouse model;multidisciplinary;Mus;Natural Immunity;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;Outcome;overexpression;Pathway interactions;Patients;personalized immunotherapy;Pharmaceutical Preparations;pharmacologic;Phenotype;Pilot Projects;Platinum;Post-Translational Protein Processing;pre-clinical;Pre-Clinical Model;predictive marker;prevent;Productivity;programmed cell death ligand 1;programmed cell death protein 1;protein expression;Proteins;Proto-Oncogene Proteins c-akt;RB1 gene;replication stress;Research;Resistance;Resolution;response;Role;Sampling;Signal Transduction;single cell technology;small cell lung carcinoma;small molecule;small molecule inhibitor;standard of care;Stimulator of Interferon Genes;Stress Response Signaling;T cell infiltration;T-Lymphocyte;TBK1 gene;Testing;Therapeutic;TP53 gene;transcriptome sequencing;Translating;Treatment Efficacy;tumor;Tumor Immunity;Work;Xenograft procedure

PROJECT_TITLE: Targeting replication stress signaling to overcome immune evasion in small cell lung cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Digestive Diseases;Liver Disease

PI_NAMEs: DRAKE, RICHARD R. (contact)

PROJECT_TERMS: Adopted;Area;Binding;Binding Proteins;Cells;Chemicals;Clinical;Complex;Coupled;Digestive System Disorders;Disease;Equipment;Evaluation;Extracellular Matrix;Extracellular Matrix Proteins;Faculty;Fibrosis;Gastrointestinal tract structure;Glycolipids;Goals;Histologic;Image;imaging approach;Imaging technology;In Situ;Infrastructure;Injury;innovation;instrumentation;Investigation;Label;Lipids;Liquid Chromatography;Liver;Liver diseases;Location;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Medical;member;Metabolic;Methodology;Methods;Molecular;new technology;novel;Polysaccharides;Post Translational Modification Analysis;Post-Translational Protein Processing;Process;Protein Analysis;protein expression;Proteins;Proteomics;Regulation;Research;Resources;Running;small molecule;South Carolina;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;System;tandem mass spectrometry;Techniques;Technology;Tissues;translational proteomics;Universities

PROJECT_TITLE: Proteomics Core


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Hearing Loss;Neurosciences;Pediatric;Rehabilitation

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: Narrative It is well established that children with mild-to-severe hearing loss are at risk for significant language delays compared to children with normal hearing, and language deficits are exacerbated by poor hearing aid fitting and inconsistent hearing aid use. However, the underlying neural mechanisms remain unknown, as very few studies have examined how such hearing loss affects the brain dynamics serving language processing in these children. The proposed study will determine the impact of mild-to-severe hearing loss and the role of hearing aid use and fit on multiple facets of language processing in children using a cutting-edge multimodal neuroimaging approach coupled with advanced behavioral and neuropsychological measures.

PI_NAMEs: HEINRICHS-GRAHAM, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Adult;Affect;Auditory;auditory processing;Automobile Driving;Awareness;behavior prediction;behavior test;Behavioral;Brain;career;Child;Clinical;Code;Cognition;Cognitive;cohort;Communication;Complex;Coupled;Data;Development;Disadvantaged;dosage;Education;Enrollment;Exhibits;falls;Functional Imaging;Goals;hard of hearing;Hearing Aids;hearing impairment;Hearing Tests;imaging approach;imaging study;Individual;Inferior;Inferior frontal gyrus;innovation;Intervention;Investigation;Knowledge;Language;Language Delays;Language Development;Language Disorders;language impairment;language processing;Left;life span;Magnetic Resonance Imaging;Magnetoencephalography;Measures;Mediating;Methods;Morphology;Motor Cortex;Multimodal Imaging;multimodal neuroimaging;multimodality;Nature;neural;neural network;neural patterning;neurodevelopment;neuromechanism;Neurons;neurophysiology;Neuropsychological Tests;Neuropsychology;Noise;non-invasive imaging;normal hearing;Outcome;Participant;Performance;phonology;precision medicine;recruit;Research;Risk;Role;School-Age Population;semantic processing;Semantics;Series;skills;spatiotemporal;Speech;Speech Perception;structural imaging;Structure;Structure of supramarginal gyrus;Task Performances;Therapeutic Intervention;Vocabulary;Vocation;Work;Youth

PROJECT_TITLE: Spatiotemporal Dynamics of Language Processing in School-Age Children with Mild-to-Severe Hearing Loss

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


PI_NAMEs: NIETERT, PAUL J (contact)

PROJECT_TERMS: Area;Basic Science;Biomedical Research;Biometry;Clinical;clinical center;Clinical Research;Clinical Trials;Collaborations;Consultations;Data;Data Coordinating Center;Dedications;design;Development;Digestive System Disorders;Disease;Education;effectiveness research;Ensure;Environment;experience;falls;Fibrosis;Fostering;Funding;Gastrointestinal Diseases;Gastrointestinal Endoscopy;Gastrointestinal tract structure;Goals;Grant;Health Sciences;Inflammation;Infrastructure;Injury;innovation;Institution;Leadership;Liver;Liver diseases;Medical;member;Multi-Institutional Clinical Trial;Multicenter Studies;National Institute of Diabetes and Digestive and Kidney Diseases;Observational Study;operation;Operations Research;Phase;Positioning Attribute;Productivity;professor;Public Health;Research;Research Design;Research Personnel;Research Priority;Research Project Grants;Research Proposals;research study;Research Support;Role;South Carolina;Structure;success;Therapeutic;Translational Research;translational study;Translations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Clinical Component


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: ROCHESTER

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Osteoarthritis (OA) is the most common cause of disability among aging adults and is a significant clinical challenge and public health burden as there is currently no treatment to prevent disease progression or induce cartilage regeneration. Chronic, low-grade inflammation in the joint is now recognized as a key contributor to OA pathogenesis, however, the source of this inflammation and its role in joint degeneration is currently unclear. The experiments outlined in this proposal are designed to examine whether aging chondrocytes are the initial source of pro-inflammatory factors due to DNA double-strand breaks and elevated activity of a protein known to initiate pro-inflammatory signaling in response to damaged DNA. Whether inhibition of this protein could be a viable therapeutic approach to preventing the onset or progression of disease will be investigated.

PI_NAMEs: JONASON, JENNIFER HARRELL (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Acceleration;Adaptor Signaling Protein;Adult;Affect;Age;Age Months;Age of Onset;age related;aged;Aging;Arthritis;articular cartilage;Automobile Driving;Biological Assay;Bleomycin;Bromodeoxyuridine;Cartilage;cartilage degradation;cartilage regeneration;Cell Aging;Cell Culture Techniques;Cell Cycle;Cell Survival;Cells;chemokine;Chondrocytes;Chronic;Clinic;Clinical;Coculture Techniques;cytokine;Data;Degenerative polyarthritis;design;Development;disability;Disease;Disease Progression;DNA Damage;DNA Double Strand Break;Endogenous Factors;endonuclease;Exhibits;experience;experimental study;Extracellular Matrix;Gene Expression;Gene Expression Profiling;Generations;Genotoxic Stress;Growth Factor;Harvest;Histology;Homing;Human;Immune;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;insight;Interferons;Investigation;joint destruction;Joints;Knee joint;Knock-out;loss of function;Mass Spectrum Analysis;Matrix Metalloproteinases;Mediating;Methods;microCT;migration;Modeling;Molecular;Mus;NF-kappa B;novel;Nuclear;paracrine;Pathogenesis;Pathway interactions;Phenotype;Population;postnatal;prevent;programs;Proliferating;Protein Inhibition;Proteins;Public Health;Reporter;response;Risk Factors;Role;senescence;senescence associated secretory phenotype;Signal Pathway;Signal Transduction;small molecule inhibitor;Source;Stimulator of Interferon Genes;STING agonists;Tamoxifen;Testing;Therapeutic;therapeutic development;Tissues;Toxic effect;transcriptome sequencing;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Chondrocyte DNA Double-Strand Breaks in the Pathogenesis of Osteoarthritis

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Reducing maternal and infant deaths and complications, expanding our understanding of medication safety and efficacy during pregnancy and lactation, and eliminating health disparities are important in improving the long term health of our country. The Columbia Center of the MFMU Network has been a leader in conducting high quality clinical trials and observational studies to address these issues to improve health outcomes for pregnant people and their infants.

PI_NAMEs: REDDY, UMA  (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: Address;Asian;Awareness;Basic Science;Black race;Bylaw;Caring;Clinical;clinical care;clinical center;clinical practice;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Collection;Communities;Complex;Country;Data;Data Collection;Dedications;Delaware;Discipline;Discipline of obstetrics;eligible participant;Enrollment;Equipment;Ethnic Origin;evidence base;experience;Genomics;Goals;Health;health disparity;Healthcare Systems;high risk;Hispanic;Hospitals;Human Resources;Image;improved;Infant;infant morbidity;Infant Mortality;Information Dissemination;innovation;Lactation;Longitudinal Studies;Longterm Follow-up;Low Birth Weight Infant;Maternal complication;Maternal Mortality;Maternal-Fetal Medicine Units Network;Maternity Hospitals;medication safety;Mentors;Morbidity - disease rate;Multi-Institutional Clinical Trial;Multicenter Neonatal Research Network;multidisciplinary;National Institute of Child Health and Human Development;Neonatology;neurodevelopment;next generation;Observational Study;obstetric care;Obstetric pharmacology;operation;Outcome;Participant;Pathology;Patient Care;patient population;Patients;Perinatal;Persons;Pharmaceutical Preparations;Placenta;Population;Population Heterogeneity;Postpartum Period;Pregnancy;pregnant;premature;Productivity;Proteomics;Protocols documentation;Provider;Publications;Qualifying;Race;randomized trial;Recovery;recruit;Research;Research Infrastructure;Research Personnel;Research Support;Resources;Safety;Saints;service delivery;Services;Site;skills;Socioeconomic Status;Specimen;Standardization;Structure;success;Supervision;System;Translational Research;Treatment Efficacy;trial design;underserved community;United States National Institutes of Health;Universities;University Hospitals

PROJECT_TITLE: Columbia University Maternal-Fetal Medicine Units Network Clinical Center


PI_NAMEs: WESTWATER, CAROLINE  (contact)

PROJECT_TERMS: Applications Grants;Area;Award;base;Biomedical Research;career;Categories;Clinical Research;Collaborations;Communities;Core Facility;Data;Dedications;design;Digestive System Disorders;Disease;Elements;Eligibility Determination;Extramural Activities;Feasibility Studies;feasibility testing;Feedback;Fibrosis;Financial Support;Fostering;Funding;Future;gastrointestinal system;Goals;improved;Inflammation;Injury;innovation;Interdisciplinary Study;interest;Laboratory Research;Letters;Link;Liver;Liver diseases;Medical;meetings;member;Mentors;Mentorship;Mission;Modeling;novel;Oral;Peer Review;Phase;Pilot Projects;Preparation;Process;programs;Qualifying;Research;Research Personnel;Research Project Grants;research study;Resources;Scholarship;Scientific Evaluation;screening;Secure;skills;South Carolina;System;Technology;Testing;Training;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: Pilot & Feasibility Program


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Drug Abuse (NIDA only);Neurosciences;Opioids;Pain Research;Pediatric;Sleep Research;Substance Misuse

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The ongoing opioid epidemic has forced the medical community to examine how it uses opioids for pain man-agement. Spinal anesthetics are able to provide analgesia without opioids while further inducing a sedated brain state, unlike in adults and older children, but the neurological basis underlying this clinical observation is not fully understood. The research project and career development activities in this K23 application, led by an anesthe-siologist-investigator at Montefiore-Einstein, will clarify neurophysiological correlates of general anesthesia and opioid-sparing spinal anesthesia with the long-term goal of improving anesthesia care in children.

PI_NAMEs: CHAO, JERRY Y (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Absence of pain sensation;Acute;Address;Adult;Age;Analgesics;Anesthesia procedures;Anesthetics;Awareness;Behavior assessment;behavior measurement;Behavioral;behavioral outcome;Brain;brain behavior;career development;Caring;Child;Child Behavior Checklist;Childhood;Clinical;Clinical Research;Cognition;Communities;Complex;Crying;Data;Data Analyses;Data Science;Data Set;Dedications;Delirium;Dependence;design;Development;Dissociation;early life exposure;Electroencephalography;Environment;Exhibits;experience;Exposure to;Face;follow up assessment;Frequencies;Funding;General Anesthesia;General anesthetic drugs;Goals;high risk;Hour;Human;hypnotic;improved;Infant;Intensive Care;irritation;K-Series Research Career Programs;Knowledge;Leg;Long-Term Effects;Measures;Medical;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Mission;Modality;motor behavior;Motor Skills;National Institute of Drug Abuse;neural;Neurologic;neurophysiology;Neurosciences;Operative Surgical Procedures;Opioid;opioid epidemic;opioid exposure;opioid sparing;opioid use;Pain;Pain management;pain score;Physicians;Physiological;Physiology;Positioning Attribute;Postoperative Period;Property;prospective;recruit;Regimen;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Research Training;Risk;risk minimization;Sample Size;Sedation procedure;sedative;skills;Sleep;sleep spindle;Spinal;Spinal Anesthesia;Substance abuse problem;substance misuse;Time;Training;Training Activity;United States;Work

PROJECT_TITLE: Analgesic-Behavioral and Neurophysiological Correlates of Opioid-Sparing Spinal Anesthesia Compared to General Anesthesia in Human Infants

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ORG_CITY: STANFORD

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Despite the large number of persons living with disabling hearing loss worldwide, medical therapies for hearing loss have remained limited. To target treatments and provide better therapies, we require a basic understanding of how the auditory system functions. In this study, I will investigate the importance of the lipid membrane in regulating the sensitivity of the auditory hair cell mechanotransduction process, a site for where multiple human genetic mutations occur, and a target of noise and age induced hearing loss.

PI_NAMEs: SAM GEORGE, SHEFIN  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Affect;Aging;Apical;Auditory;Auditory system;Biochemical;Biophysics;BODIPY;Body Temperature;Buffers;Calcium;Calibration;career;Cell Physiology;Cells;Cholesterol;Cochlea;Data;deafness;Development;Disabling;Disease;DNA Sequence Alteration;Electrophysiology (science);Environment;experimental study;extracellular;Extracellular Protein;Failure;fluorescence lifetime imaging;Genetic Diseases;Goals;Hair;Hair Cells;Hearing;hearing impairment;hearing loss treatment;Human Genetics;Image;improved;Individual;insight;Ion Channel;Ions;Lead;Learning;Link;Lipid Bilayers;Lipids;Measures;Mechanics;mechanotransduction;Mediating;Medical;Membrane;Membrane Lipids;Microscopy;Molecular;Monitor;neuronal cell body;new technology;Noise;novel;Organ of Corti;Persons;Phosphatidylinositol 4,5-Diphosphate;Phospholipids;Photobleaching;Play;Positioning Attribute;Presbycusis;Probability;Process;Property;Proteins;Recovery;Research Personnel;Resolution;response;Rest;Role;sensor;Sensory Hair;Signal Transduction;Site;sound;spatiotemporal;Stereocilium;Stretching;Surface;System;targeted treatment;Techniques;Technology;technology/technique;Testing;Time;time use;Translating;Translations;two-photon;Viscosity;voltage

PROJECT_TITLE: Investigating the role of lipid membrane in the cochlear hair cell mechanotransduction


NIH_SPENDING_CATS: Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE Generation of induced neuronal (iN) cells from human pluripotent stem cells (hPSCs) offers great potential for central nervous system (CNS) disease modeling and drug screening, however, current differentiation methods are often laborious, time-consuming, and inefficient. It is increasing clear that mechanical forces provide overarching signals for cell fate choice, but how the mechanochemical signaling transmit to the nucleus and alters the chromatin structure is unclear. Here, I propose to investigate a novel intrinsically-regulated mechano- signaling pathway impact on the nuclear organization of the genome to promote neuronal differentiation, which besides advancing fundamental understanding of neuronal lineage specification, this project will establish a new ‘force-based’ method for the generation of iNs, thus facilitating hPSC-based strategies to model and potentially to treat CNS diseases.

PI_NAMEs: JUNQUEIRA ALVES, CHRYSTIAN  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: 3-Dimensional;Acceleration;Actomyosin;Adhesions;Affect;AMOT gene;Architecture;axon guidance;Cell Line;Cell Nucleus;cell replacement therapy;Cells;Cellular Structures;Central Nervous System Diseases;Chromatin;Chromatin Structure;Clustered Regularly Interspaced Short Palindromic Repeats;Competence;Consumption;Cytoskeleton;Data;disease model;Doxycycline;drug discovery;Drug Screening;Electrophysiology (science);Elements;Epigenetic Process;epigenomics;gain of function;Gene Expression;Generations;Genes;Genetic Epistasis;Genetic Transcription;Genome;genomic locus;Goals;Histones;Human;human embryonic stem cell;human pluripotent stem cell;improved;Induced Neurons;Induced pluripotent stem cell derived human neuron;interest;Investigation;knock-down;Knock-out;Lamins;Link;loss of function;Maps;mechanical force;Mechanics;mechanotransduction;Mediating;Mediator;Mentored Research Scientist Development Award;Mentors;Methods;Modeling;Morphology;nerve stem cell;Nervous System Disorder;neural;Neuronal Differentiation;Neurons;neurotransmitter release;novel;Nuclear;Nuclear Envelope;Nuclear Structure;Pathway interactions;Phosphorylation;physical property;plexin;Proliferating;Property;Proteins;Publications;receptor;Regulation;response;Role;Signal Transduction;skills;small hairpin RNA;Specific qualifier value;stem cells;Testing;Time;Training;transcriptomics;transmission process;United States National Institutes of Health;Writing

PROJECT_TITLE: Generation of Neurons by Force-Mediated Epigenetic Mechanisms through Manipulation of Intrinsic Mechanoregulators


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative Loss of neurons that produce the neuromodulatory neurotransmitter acetylcholine in the basal forebrain are correlated with cognitive decline in Lewy Body Dementia, and loss of these neurons is predictive of patients with Parkinson’s Disease developing Parkinson’s Disease Dementia. This project aims to understand how loss of acetylcholine release or signaling in mouse models of Lewy Body Dementia lead to cortical dysfunction and subsequent cognitive decline. The successful completion of this project will not only lead to a better understanding of how cortical dysfunction leads to cognitive decline, but will also lead to a better understanding of how to leverage cholinergic signaling for novel therapeutics in Lewy Body Dementia.

PI_NAMEs: MOEHLE, MARK S (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Acetylcholine;alpha synuclein;Alzheimer's Disease;Anatomy;Animal Model;Attention;Basal Cell;basal forebrain;Behavioral;Brain;Brain region;Cell Nucleus;Cells;cholinergic;Cognition;Cognitive;comparison control;Data;Data Correlations;Dementia;Dementia with Lewy Bodies;designer receptors exclusively activated by designer drugs;Electrophysiology (science);Executive Dysfunction;executive function;experimental study;flexibility;Functional disorder;Glutamates;hippocampal pyramidal neuron;Impaired cognition;Impairment;insight;Lead;Lewy Bodies;Lewy Body Dementia;Lewy neurites;Link;Long-Term Depression;Measures;Medial;Modeling;mouse model;Mus;Muscarinic Acetylcholine Receptor;Nervous System Disorder;neuron loss;neuronal circuitry;neuronal excitability;Neurons;neuroregulation;Neurotransmitters;Nicotinic Receptors;novel therapeutic intervention;novel therapeutics;Output;Parkinson Disease;Parkinson's Dementia;Pathologic;Patients;pharmacologic;postsynaptic;pre-formed fibril;Prefrontal Cortex;presynaptic;Property;Pyramidal Cells;receptor;Regulation;Role;Series;Signal Transduction;Source;Symptoms;Synapses;Synaptic plasticity;synucleinopathy;System;Testing

PROJECT_TITLE: Cholinergic Mechanisms in Lewy Body Dementia

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Lung;Neurosciences;Physical Rehabilitation;Rehabilitation;Sleep Research;Stroke

ORG_CITY: SEATTLE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Continuous positive airway pressure (CPAP) for the treatment of obstructive sleep apnea (OSA), an under- recognized but common disorder after stroke, holds promise to improve stroke outcomes but is severely limited by poor post-stroke adherence. We propose to adapt and refine a multicomponent CPAP adherence intervention for stroke patients and then test it among stroke patients. Optimization of CPAP use among stroke patients will allow for the conduct of rigorous clinical trials of OSA treatment after stroke and ultimately to advance the care of stroke patients.

PI_NAMEs: BROWN, DEVIN L;KHOT, SANDEEP  (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Address;Adherence;Adult;Affect;arm;Behavior Therapy;Cardiovascular system;Caring;Cessation of life;clinical care;Clinical Trials;Cognitive;Competence;Continuous Positive Airway Pressure;Control Groups;Counseling;Data;design;Development;disability;Disabling;Disease;Effectiveness;effectiveness testing;efficacy evaluation;efficacy testing;Electronic Mail;Event;Exclusion;Feedback;follow-up;Functional disorder;functional outcomes;Funding Opportunities;General Population;Goals;group intervention;Hand;Health Technology;human centered design;Impaired cognition;Impairment;improved;Inpatients;Intervention;intervention cost;Interview;Language;Libraries;Long term disability;mHealth;Monitor;motivational enhancement therapy;multi-component intervention;multimodality;Nature;Obstructive Sleep Apnea;Participant;Patients;Pilot Projects;pilot trial;post stroke;prevent;primary outcome;Process;programs;Protocols documentation;Randomized;Randomized, Controlled Trials;Recovery;Recurrence;Rehabilitation therapy;Research Personnel;Risk;Secure;Self Determination;Self Management;Site;skills;Sleep Apnea Syndromes;Stroke;stroke intervention;stroke outcome;stroke patient;Stroke prevention;stroke recovery;stroke survivor;stroke trials;success;tailored messaging;Telephone;Testing;Text;theories;Training;Treatment Efficacy;United States;Work

PROJECT_TITLE: Optimizing adherence to the treatment of sleep apnea among patients with strokeundergoing inpatient rehabilitation

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Immunotherapy;Networking and Information Technology R&D (NITRD);Orphan Drug;Ovarian Cancer;Precision Medicine;Rare Diseases;Women's Health Research

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Narrative Tumor cells and the microenvironment are rewired in response to targeted therapeutics, resulting in adaptive responses, including compensatory oncogenic pathway activation and changes in tumor ecosystem heterogeneity, leading to drug resistance and relapse. Blocking therapy-induced adaptive responses with rational drug combinations that are designed to interdict the emergence of resistance is predicted to yield more durable responses, and significantly improve patient benefits; however, the discovery of effective combinations is highly challenging due to the complexity and diversity of adaptive mechanisms within the tumor ecosystem. We will discover combination therapies that interdict adaptive responses in the tumor ecosystem through comprehensive drug response profiling from single cells and bulk tissues, data-driven mathematical modeling to predict responses to untested perturbations, subsequent in vitro/in vivo validation, and data-guided clinical trials.

PI_NAMEs: KORKUT, ANIL ;LIANG, HAN ;MILLS, GORDON B. (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Algorithms;Anatomy;Automobile Driving;Bioinformatics;biological adaptation to stress;Breast;Cancer Biology;cancer clinical trial;Cell Line;Cells;Clinical Research;clinical trial implementation;Clinical Trials;clinically relevant;Collaborations;Combination immunotherapy;combinatorial;Combined Modality Therapy;Computational Biology;Computer Models;computerized tools;Data;data acquisition;Data Set;Data Sources;data-driven model;design;Disease;DNA Damage;Drug Combinations;drug relapse;Drug resistance;Ecosystem;Funding;Funding Mechanisms;Future;Generations;Heterogeneity;Image Analysis;immune checkpoint;Immune checkpoint inhibitor;Immunofluorescence Immunologic;Immunology;Immunomodulators;immunoregulation;improved;In Vitro;in vivo;in vivo Model;innovation;insight;Isogenic transplantation;Libraries;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;mathematical model;MEKs;Modeling;Molecular;Monitor;multiplexed imaging;Mus;neoplastic cell;Network-based;new therapeutic target;novel;novel drug combination;novel therapeutics;Oncogenic;Outcome;Ovarian;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Periodicity;Pharmaceutical Preparations;PIK3CG gene;pre-clinical assessment;Pre-Clinical Model;predicting response;Prediction of Response to Therapy;predictive modeling;Process;Productivity;programmed cell death ligand 1;programs;Proteins;Proteomics;Recording of previous events;Resistance;resistance mechanism;response;Sampling;Serous;Signal Transduction;spatiotemporal;Stress;Systems Biology;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;therapy resistant;Tissues;tool;transcriptomics;translational cancer research;Transplantation;treatment response;triple-negative invasive breast carcinoma;tumor;tumor heterogeneity;tumor microenvironment;tumor-immune system interactions;University of Texas M D Anderson Cancer Center;Validation;virtual;Xenograft procedure

PROJECT_TITLE: Mechanistic maps of adaptive responses to therapeutic stress to optimize combination therapies.


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infant Mortality;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Obstetric admissions are the leading cause of hospitalization in the United States, and a significant portion of the obstetric population experiences adverse outcomes that may adversely affect the short- and long-term health of both birthing individuals and their infants. In addition, disparities in maternal and infant morbidity and mortality are profound, and coordinated, rigorous, and definitive scientific efforts are required to improve obstetric outcomes and reduce inequity. The Northwestern Study Center, as part of the Maternal-Fetal Medicine Units (MFMU) Network, will substantively contribute to the MFMU Network’s large-scale clinical trials and observational studies that are needed to improve obstetric outcomes, reduce disparities, and thereby enhance public health.

PI_NAMEs: YEE, LYNN M (contact)

PROJECT_TERMS: Address;Admission activity;Adverse event;adverse outcome;adverse pregnancy outcome;Advisory Committees;Affect;Birth;Black race;Cardiovascular Diseases;Caring;Child;Childbirth;Clinical;clinical center;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Collection;community engagement;Congresses;Data;Data Coordinating Center;diagnostic strategy;Discipline of obstetrics;Disparity;disparity reduction;Education;Enrollment;Environment;ethnic minority;experience;Future;Goals;Health;Health Care Costs;health goals;health inequalities;Health system;high risk;Hispanic;Hospitalization;Hypertension;improved;improved outcome;Indigenous;Individual;Inequity;Infant;infant morbidity/mortality;innovation;Institution;Lactation;Lead;Leadership;Longterm Follow-up;low socioeconomic status;marginalized population;Maternal and Child Health;maternal morbidity;Maternal Mortality;maternal outcome;Maternal-Fetal Medicine Units Network;member;Minority Groups;Mission;Morbidity - disease rate;mortality;Mothers;Multi-Institutional Clinical Trial;Multicenter Neonatal Research Network;National Institute of Child Health and Human Development;neonatal outcome;neonate;novel;Observational Study;obstetric care;obstetric outcomes;offspring;organizational structure;Outcome;participant retention;patient population;Patient Recruitments;Perinatal mortality demographics;Persons;Population;Population Heterogeneity;post pregnancy;Postpartum Period;Pregnancy;pregnancy disorder;pregnancy health;pregnant;premature;Premature Birth;Prevention;Process;Productivity;Protocols documentation;Public Health;racial minority;racism;Recording of previous events;Recovery;recruit;Reproducibility;Research;Research Design;Research Infrastructure;Research Personnel;Resources;retention rate;Risk;screening;severe maternal morbidity;Site;socioeconomics;Source;Strategic Planning;Techniques;Therapeutic;Therapeutic Intervention;Underrepresented Populations;United States;Universities;Woman

PROJECT_TITLE: Maternal Fetal Medicine Units Network - Northwestern Study Center


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Lung;Lung Cancer;Pediatric;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Waterpipe tobacco smoking is common among young adults in the U.S. There are significant health effects associated with waterpipe tobacco smoking, but young adults erroneously believe it to be less harmful and addictive than cigarette smoking. This project will develop and test health warnings to increase young adults' accurate perceptions of harm and decrease use, which will lead to reductions in tobacco-related diseases, including cancers.

PI_NAMEs: SUTFIN, ERIN L (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, ANNETTE R

PROJECT_TERMS: Acute;addiction liability;Address;Advertisements;Age;age group;Aldehydes;arm;Aromatic Polycyclic Hydrocarbons;arterial stiffness;Attitude;authority;Behavior;Behavioral;Biological Markers;cancer prevention;cancer risk;Carbon Monoxide;carcinogenicity;Cardiovascular system;Central Nervous System;Chemicals;Chronic;Cigarette;cigarette smoking;Cognitive;combustible tobacco;Communication;Consumption;Cross-Over Trials;Dependence;design;Development;Disease;Effectiveness;Epidemiology;experimental study;Exposure to;Federal Government;federal policy;Goals;Health;health warning;Heavy Metals;High Prevalence;hookah;Image;Intervention;Knowledge;Legal;Libraries;Local Government;Lung;Malignant Neoplasms;Measures;Motivation;negative affect;New York City;Nicotine;Nicotine Dependence;Perception;Policies;Population;prevent;prospective;Public Health;Randomized;Regulation;Research;Risk;Risk Behaviors;Sales;Sampling;Science;smoking initiation;State Government;Surveys;Testing;Text;Tobacco;tobacco prevention;Tobacco smoking behavior;Tobacco use;Tobacco-Related Carcinoma;Toxic effect;toxicant;United States Food and Drug Administration;Use Effectiveness;Volatilization;young adult

PROJECT_TITLE: Communicating Waterpipe Tobacco Harms to Reduce Use among Young Adults

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Digestive Diseases;Genetics;Human Genome;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Public Health Relevance Statement  The enteric nervous system (ENS) is a critical part of the peripheral nervous system that controls gut motility and other functions. Abnormal development of ENS leads to life threatening disorders like Hirschsprung’s disease. Our results will provide important clues regarding mistakes that may lead to birth defects in the ENS.

PI_NAMEs: BRONNER, MARIANNE  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Autonomic nervous system;Birth;Cell Lineage;cell motility;cell type;Cells;Chick;Childhood;cholinergic neuron;Colon;Complex;Congenital Abnormality;Congenital Megacolon;CRISPR/Cas technology;Data Set;Defect;Development;Disease;Distal;dopaminergic neuron;Embryo;Enhancers;Enteral;Enteric Nervous System;Event;experimental study;Fertilization;Fluorescent in Situ Hybridization;Ganglia;Gastrointestinal Motility;Gene Expression;Gene Expression Profiling;gene regulatory network;Genetic;genetic manipulation;Genetic Transcription;hindbrain;Human;imaging facilities;Individual;interest;Intestines;Jaw;Knock-out;Lead;Left;Length;Life;Mediating;migration;Mining;Molecular;Motility;Mus;Mutate;Mutation;Nervous System control;nervous system development;Neural Crest;Neural Crest Cell;Neuronal Differentiation;Neurons;Neurotransmitters;Nitric Oxide;Pattern;Peripheral Nervous System;Play;Population;Primitive foregut structure;progenitor;Proteins;public health relevance;Reaction;Regulatory Element;Reporter;Resolution;Role;Side;Signal Pathway;Signal Transduction;Signaling Molecule;single cell ATAC-seq;single cell technology;single molecule;single-cell RNA sequencing;Sorting;Specific qualifier value;Stream;Substance P;teleost;Testing;Time;tool;transcription factor;Transcriptional Regulation;transcriptome;Transgenic Organisms;Undifferentiated;Validation;Vertebrates;Zebrafish

PROJECT_TITLE: Transcriptional regulation of neuronal cell lineage decisions in the developing enteric nervous system

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: LAS VEGAS

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: Project Narrative The ACTION Initiative will develop a Clinical Trial Observatory (CTO) with an embedded mentorship program to address the NIA Alzheimer's Disease and Related Dementias Research Implementation Milestones. The CTO will use artificial intelligence with machine learning and trial statistics to interrogate Alzheimer's clinical trial data from the comprehensive federal trial registry, clinicaltrials.gov. Initial mentees have been selected and more will be integrated into the program as the CTO and related programs mature.

PI_NAMEs: CUMMINGS, JEFFREY L. (contact)

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Area;Articulation;Artificial Intelligence;Award;Bioinformatics;Biological Markers;Characteristics;Clinical;Clinical Research;Clinical Trials;Collaborations;Complex;computer scientist;Congresses;Data;data registry;Databases;deep learning;Dementia;Development;drug development;drug mechanism;Engineering;Ensure;Future;Goals;Growth;Industry;Information Dissemination;innovation;Laws;Leadership;Machine Learning;Mentors;Mentorship;Modeling;multidisciplinary;National Institute on Aging;Neuropsychology;novel therapeutics;Outcome;pharmacologic;Phase;pre-clinical;Principal Investigator;programs;Psychiatry;Publishing;Registries;Research;Research Personnel;Risk;Site;statistics;Techniques;Translational Research;trial design;trial planning;web portal

PROJECT_TITLE: Alzheimer's Clinical Trial InnOvatioN (ACTION) Initiative


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Endocrine Disruptors;Heart Disease;Nutrition;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: PROJECT NARRATIVE Per- and polyfluoroalkyl substances (PFAS) are persistent “forever chemicals” associated with developmental toxicity, but data are lacking in older adults in whom altered metabolism, decreased clearance, and hormonal changes may heighten PFAS vulnerability. This study will investigate the impact of PFAS exposure across midlife and older age on (1) musculoskeletal health and (2) cardiovascular disease in older adults, and (3) the potential for lifestyle behaviors to mitigate these health impacts. Our findings will inform PFAS legislation and health guidance for exposed individuals, with implications for musculoskeletal and cardiovascular risk reduction.

PI_NAMEs: FLEISCH, ABBY ;OKEN, EMILY  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: abdominal fat;Address;adjudication;Adult;age related;Age Years;Aging;Anti-Inflammatory Agents;arm;Attenuated;Behavior;Behavior Therapy;Biological;Biological Assay;bone mass;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cessation of life;chemical association;Chemicals;Cholesterol;cohort;Cohort Studies;Communities;Congestive Heart Failure;contaminated water;Coronary;Coronary Arteriosclerosis;cost;cytokine;Data;developmental toxicity;diabetes prevention program;diabetes risk;Diet;dietary;Dual-Energy X-Ray Absorptiometry;ethnic diversity;Event;Exercise;Exposure to;Fatty acid glycerol esters;follow-up;Food;Functional disorder;Funding;good diet;grasp;Hand;Hand Strength;Health;Hormonal Change;Hormones;Hospitalization;human old age (65+);improved;Individual;Industrialization;Inflammatory;Insulin Resistance;Intake;Intervention;Life;Life Style;lifestyle factors;lifestyle intervention;Longitudinal cohort;Longitudinal cohort study;Manufacturer;Measures;Metabolism;Metformin;middle age;Modeling;Modification;Muscle;muscle form;muscle strength;Musculoskeletal;Myocardial Infarction;National Institute of Environmental Health Sciences;novel;older adult;Omega-3 Fatty Acids;Outcome;Outcome Study;Participant;Peripheral;Phase;Physical activity;Placebos;Plasma;Policies;Poly-fluoroalkyl substances;Population;post intervention;Predisposition;Preventive;Production;Productivity;prospective;prospective test;Public Policy;racial diversity;Randomized;randomized trial;reduced muscle mass;Reporting;Research Priority;Resources;revascularization;Risk;Risk Reduction;Role;Sample Size;Scanning;Statistical Methods;Statutes and Laws;Strategic Planning;Stroke;Testing;Therapeutic;Unstable angina;water quality;Work

PROJECT_TITLE: Long-term prospective associations of PFAS with musculoskeletal and cardiovascular health among older adults

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Aging;Biotechnology;Cardiovascular;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Columbus

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Mitophagy is a critical mechanism to preserve cardiovascular homeostasis by selectively eliminating dysfunctional mitochondria. This project aims to delineate novel molecular mechanisms connecting mitophagy to neddylation, and to assess the physiological implications of mitophagy in cardiac aging. These studies will lead to a greater understanding of how neddylation is linked to mitochondrial quality control, and provide the groundwork for the development of novel therapeutic approaches to combat age-related cardiac dysfunction.

PI_NAMEs: SUN, NUO  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Adult;Adverse effects;Age;age effect;age related;age related decline;age-related disease;aged;Aging;aging related;Algorithm Design;Algorithms;Binding Proteins;Biological Assay;Cardiac;cardiac aging;Cardiac Myocytes;cardioprotection;cardiovascular health;Cardiovascular Physiology;Cardiovascular system;Cell Culture Techniques;Collection;combat;Complex;Cullin 2 Protein;Data;Development;disorder risk;Elderly;elongin B;Enzymes;Genetic;Goals;Heart;Heart failure;heart function;Homeostasis;HRK gene;Human;human induced pluripotent stem cells;hypoxia inducible factor 1;Image;improved;in vivo monitoring;induced pluripotent stem cell;inhibitor;innovation;insight;Intervention;Link;Longevity;Mediating;Mitochondria;model organism;Molecular;mortality;mouse model;Mus;Myocardial dysfunction;Myocardial tissue;normal aging;novel;novel therapeutic intervention;old mice;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Physiological;Post-Translational Protein Processing;preservation;prevent;Proteins;Quality Control;RBX1 gene;Reagent;receptor;Regulation;Rejuvenation;Reporter;Research;Role;Scaffolding Protein;spatiotemporal;Therapeutic;therapeutic target;Tissue Sample;Ubiquitin;Ubiquitin Like Proteins;ubiquitin-protein ligase;Ubiquitination;VHL protein;young adult

PROJECT_TITLE: Neddylation and mitophagy in cardiac aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Infectious Diseases;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: NORTH CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI

PHR: This project seeks a deep understanding of a major mechanism underlying multidrug resistance, which may inform new therapeutic strategies for combatting infectious diseases and human cancers. Our proposed work will also elucidate the molecular underpinnings of vesicular neurotransmitter and neurotoxin sequestration, which can facilitate the treatment of alcoholism, autism, bipolar disorder, Huntington disease, major depressive disorder, Parkinson’s disease, schizophrenia and other neuropsychiatric ailments.

PI_NAMEs: LU, MIN  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Alcoholism;alcoholism therapy;Amino Acids;antimicrobial;Antimicrobial Resistance;antiport;antiporter;autism spectrum disorder;Binding;Biochemical;Biological;Bipolar Disorder;Brain;Cell membrane;Cells;Chemical Structure;Clinical;clinically relevant;Communicable Diseases;Complex;Coupled;Couples;Crystallography;Data;deprotonation;Development;Drug Binding Site;Drug Efflux;Drug Modelings;effective therapy;Escherichia coli;experience;Family;Gilles de la Tourette syndrome;Goals;Human;Huntington Disease;Infection;inhibitor;insight;Integral Membrane Protein;Ligand Binding;Ligands;Major Depressive Disorder;Malignant Neoplasms;Mediating;Membrane;membrane model;Membrane Proteins;Mental Depression;microorganism;Modeling;Molecular;monoamine;Movement;multi drug transporter;Multi-Drug Resistance;Mutagenesis;mutant;Mutate;Nervous System Disorder;Neuromodulator;neuropsychiatry;Neurotoxins;neurotransmission;Neurotransmitters;novel strategies;novel therapeutic intervention;overexpression;Parkinson Disease;pathogenic bacteria;Pathogenicity;Patients;Pharmaceutical Preparations;Physiological;Polyamines;Process;Protein Export Pathway;Proteins;protonation;Publishing;Reporting;Research;Roentgen Rays;Schizophrenia;Site;solute;structural biology;Structure;targeted treatment;Therapeutic;therapeutic target;Transmembrane Transport;Treatment Efficacy;unpublished works;Variant;vesicle transport;Work

PROJECT_TITLE: Molecular Basis of Substrate Translocation in the Drug/H+ Antiporter 1 Family

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Alcohol and substance use disorders (ASUD) is a major public health issue and studies to examine barrier to ASUD treatment access and engagement, as well as preferences for treatment are needed. This project will leverage individual-level data across multiple studies to examine barriers to ASUD treatment access and treatment engagement. It will also examine on the ASUD treatment preferences to enhance services for individuals with ASUD.

PI_NAMEs: SANTOS, GLENN-MILO  (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Acceleration;Address;Advanced Development;AIDS prevention;Alcohol consumption;alcohol services;alcohol use disorder;Area;Behavioral;burden of illness;career development;Caring;Categories;Complex Analysis;Data;Data Analyses;Data Set;disability-adjusted life years;efficacious intervention;ethnic identity;Ethnic Origin;experience;experimental study;Gender;Gender Identity;Health;Health Services Accessibility;HIV;HIV risk;Homelessness;Homophobia;Human Resources;Imprisonment;Individual;Intervention;Intervention Studies;Measures;medication compliance;Mentors;Methodology;Morbidity - disease rate;mortality;National Institute of Drug Abuse;National Institute on Alcohol Abuse and Alcoholism;novel;Outcome;Participant;patient oriented research;Persons;Pharmacotherapy;polysubstance use;Population;Populations at Risk;preference;programs;psychological distress;Psychosocial Factor;Public Health;Race;racial identity;racism;reduced alcohol use;Research;Research Personnel;Research Project Grants;resilience;Role;Sample Size;Sampling;scale up;Services;sex;Sex Discrimination;Sexism;skill acquisition;social;social capital;social group;social stigma;Social support;Source;Statistical Models;structural determinants;Structure;Subgroup;substance use;Substance Use Disorder;substance use treatment;Surveys;syndemic;Training;transphobia;Treatment outcome;treatment strategy;Treatment/Psychosocial Effects;uptake;Visit;Work;years of life lost

PROJECT_TITLE: ASTERISK: Alcohol and Substance use Treatment and Engagement Research on Intervention Studies among Key populations

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Behavioral and Social Science;Social Determinants of Health

ORG_CITY: SAN MARCOS

ORG_NAME: CALIFORNIA STATE UNIVERSITY SAN MARCOS

PHR: NARRATIVE The CSU San Marcos U-RISE Program will prepare students from underrepresented (UR) and disadvantaged groups for careers in biomedical and behavioral research and will serve to advance the goals of the National Institutes of Health to diversify the research workforce. A more diverse research workforce will better address the research needs of a diverse nation and thereby contribute to better health for all.

PI_NAMEs: GARCIA, DENISE  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Academia;Address;Asian Americans;Behavioral Sciences;Biomedical Research;California;career;college;Communication;County;Doctor of Philosophy;Environment;Evidence based practice;experience;Exposure to;Family;Fellowship;Future;Goals;graduate school;Grant;Health;Hispanic;Hispanic-serving Institution;Home;Institution;Knowledge;Learning Skill;Length;Low income;Methodology;Native Americans;Not Hispanic or Latino;Pacific Islander;Pathway interactions;pedagogy;Performance;Population;Positioning Attribute;programs;recruit;Research;Science;Scientist;skills;student participation;Students;success;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities

PROJECT_TITLE: U-RISE at California State University San Marcos

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT RELEVANCE / NARRATIVE This research is highly relevant to public health because the organism under study causes serious human illness for which current therapies are not adequate. Cryptococcus neoformans generates a variety of carbohydrate- containing molecules, many of which are not present in mammals; defining their biosynthetic processes may advance treatment of cryptococcal infection. This work will also contribute to basic science knowledge, which will provide insights into other pathogenic fungi and areas of biology.

PI_NAMEs: DOERING, TAMARA L (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Affect;anti-fungal agents;Antifungal Therapy;Area;Basic Science;Binding;Biochemical;Biochemical Pathway;Biological;Biological Assay;Biology;Candida;capsule;Carbohydrates;Cell Fraction;Cell membrane;Cell surface;Cell Survival;Cell Wall;Cells;Cessation of life;Characteristics;Chitin;Chitosan;Communities;Complex;Cryptococcus;Cryptococcus neoformans;Dangerousness;Developing Countries;Drug Targeting;Engineering;Environment;Enzymes;experimental study;extracellular;fascinate;flexibility;fungus;Future;gene product;Genes;Glucans;Glycogen;glycosyltransferase;Goals;Growth;Hand;HIV;Human;improved outcome;Individual;Infection;insight;Intervention;Investigation;Knowledge;Link;Location;Mammalian Cell;Mammals;Mannose;Measures;Microbe;Morbidity - disease rate;mutant;Nature;neglect;novel;Organism;pathogen;Pathogenesis;pathogenic fungus;patient population;Phagocytes;Pharmaceutical Preparations;Phenotype;Physiological;Polymers;Polysaccharides;Process;Productivity;protein purification;Proteins;Public Health;Reaction;Reporting;Research;resilience;Resistance;Role;Saccharomyces;screening;Severity of illness;Stress;Structure;synthetic enzyme;System;Testing;Traction;Virulence;Visit;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Filling gaps in the cryptococcal wall with glycogen and a novel enzyme

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: PROJECT NARRATIVE The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10 year-olds to be followed over 10 years, to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the scientific community to address a comprehensive range of questions concerning youth development.

PI_NAMEs: HERTING, MEGAN MARIE;SOWELL, ELIZABETH R (contact)

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Behavior;Behavioral;Bioinformatics;Biological;Biological Assay;Biology;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Child Health;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Country;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;follow-up;Funding;gene interaction;Genetic;Health;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;Longitudinal Studies;marijuana use;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Pathway interactions;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Recurrence;Registries;Research;research and development;Research Personnel;Research Project Grants;Resource Informatics;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;sleep pattern;social;Social Functioning;Social isolation;social media;Specific qualifier value;Sports;Standardization;substance use;Symptoms;Technology;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;United States;vaping;Video Games;young adult;Youth

PROJECT_TITLE: 8/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT CHLA