NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE This study will test innovative multi-level interventions at the practice (primary care) and provider (physician, nurse practitioner) levels to increase dental attendance and improve overall health and quality of life for adults aged ≥ 55 years attending primary care visits. The behavioral interventions at the provider level and implementation strategies at the practice level will help older adults better understand the importance of oral health and to seek dental care for themselves. These novel interventions have the potential for a new oral health care model for primary care providers.

PI_NAMEs: NELSON, SUCHITRA S. (contact)

PROGRAM_OFFICER_NAME: ELWOOD, WILLIAM N

PROJECT_TERMS: Academy;Address;Adoption;Adult;Affect;aged;Aging;arm;Attention;Behavior;behavior change;behavior influence;Behavior Therapy;Behavioral;behavioral and social science;Belief;Biometry;burden of illness;Caring;Child Health;Cognitive;Collaborations;Communication;Community Practice;Data;Data Analyses;Data Collection;Dental;Dental Care;Dental caries;Dental Hygiene;Dentists;design;Diagnosis;Documentation;Education;Educational Curriculum;efficacy testing;Electronic Health Record;electronic health record system;Electronics;Enrollment;Equation;Exclusion;experience;Health;health assessment;health care model;health disparity;Health education;Health system;health training;Healthcare;Hospitalization;implementation strategy;improved;Informal Social Control;innovation;Intervention;intervention effect;Knowledge;Literature;Low income;Maintenance;Manuals;Measures;Mediation;Mediator;Medicaid;Medicaid eligibility;Medical;Medical Care Costs;Medical Staff;Medicare;Medicine;Methods;Modeling;Mouth Diseases;novel;Nurse Practitioners;Nurses;Ohio;older adult;Oral cavity;oral communication;Oral health;Outcome;Outcomes Research;Paper;Pathway interactions;Patients;Perception;Periodontitis;Personal Satisfaction;Phase;Physicians;Physicians' Offices;pilot test;Population;prevent;Primary Care;primary care clinician;primary care provider;primary care setting;primary care visit;primary medical care;primary outcome;Printing;Procedures;Process;Process Measure;Professional Organizations;Protocols documentation;Provider;Publishing;Quality of life;Questionnaires;quitline;Randomized;randomized, clinical trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Recommendation;recruit;Reporting;Resources;Risk Assessment;Risk Factors;Sample Size;Sampling;secondary outcome;Site;skills;skills training;smoking cessation;Source;statistics;stem;Structure;Surveys;System;systematic review;Systemic disease;Testing;theories;Tooth Diseases;Tooth Loss;Tooth structure;Training;Training and Education;Trust;United States National Institutes of Health;Universities;Visit;web site;willingness;Work;Writing

PROJECT_TITLE: Multi-Level Interventions to Reduce Oral Health Disparities among Adults in Primary Care Settings


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: SANTA BARBARA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: CHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

ORG_STATE: CA

PHR: Project Narrative General strategies to impose stereocontrol over radical-mediated transformations have long eluded synthetic chemists. By repurposing and engineering naturally occurring metalloenzymes for new-to-nature metalloredox processes, we will develop biocatalytic radical reactions that occur with excellent stereochemical fidelity. Ultimately, this evolvable metalloenzyme platform will allow for the rapid assembly of clinically significant therapeutics of general societal importance.

PI_NAMEs: YANG, YANG  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: An Evolvable Metalloenzyme Platform for Stereoselective Radical Biocatalysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This revision is a diversity administrative supplement request to our RF1 project to support UCLA Neuroscience Interdisciplinary Program PhD candidate Matthew Anderson. The project will enable Matthew to develop a novel tool for endothelial cell profiling that is related to the goals of this RF1 project focused on identifying mechanisms for the vascular regulation of myelination.

PI_NAMEs: HINMAN, JASON D (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Acceleration;Address;Administrative Supplement;Affinity Chromatography;age related;Age-associated memory impairment;Albumins;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Diseases;Animals;antagonist;Automobile Driving;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;Brain;brain endothelial cell;Brain Injuries;Brain Ischemia;Brain region;Capsid;Cardiovascular system;career;Cell Communication;cell injury;Cells;cerebrovascular;Cerebrovascular system;Cerebrum;chemokine;chemokine receptor;Chemotaxis;Chronic;Clinical;comorbidity;Conditioned Culture Media;CXCL5 gene;Data;dementia risk;Development;Diabetes Mellitus;Disease;Disease Progression;DNA cassette;Doctor of Philosophy;Endothelial Cells;endothelial dysfunction;Endothelium;Evans blue stain;Functional disorder;gain of function;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;genetic manipulation;Gliosis;Goals;Homeostasis;Hypertension;IL17 gene;IL8RB gene;Immunoglobulin G;Immunoprecipitation;Impaired cognition;In Vitro;in vivo;Infarction;Inflammatory;Injections;injured;Injury;innovation;Interleukins;Ischemia;ischemic lesion;Knock-out;Label;Lesion;Literature;loss of function;Measurement;Measures;Mediating;Methodology;Microvascular Dysfunction;migration;Molecular;Molecular Profiling;motor impairment;Mouse Strains;Mus;myelination;Nature;Nerve Degeneration;Neurosciences;new therapeutic target;novel;Obesity;oligodendrocyte progenitor;Pathogenesis;Pathology;Pathway interactions;Pattern;Peripheral;post stroke;prevent;programs;receptor;Receptor Activation;Regulation;remyelination;repaired;Research;Resistance;response;Ribosomes;RiboTag;Risk Factors;RNA;Role;Signal Pathway;Signal Transduction;single cell technology;Site;small molecule;Specificity;stem cell population;stem cells;Stroke;stroke risk;Systemic infection;Techniques;therapy design;Time;tissue processing;Tissues;tool;transcriptome sequencing;Transgenic Model;Translating;Use of New Techniques;Variant;vascular abnormality;vascular cognitive impairment and dementia;Vascular Diseases;vascular risk factor;Viral;Virus;Visualization;white matter;white matter injury;Work

PROJECT_TITLE: Mechanisms for vascular regulation of remyelination in white matter injury


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE  The healthy growth and development of infants and young children are critical for them to reach their full physical and mental potential. Our proposed studies aim to understand the molecular mechanism of KBTBD2 deficiency in the development of growth retardation. This research has the potential to reveal novel therapeutic targets for treating childhood growth disorders.

PI_NAMEs: ZHANG, ZHAO  (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Address;Adipose tissue;Adult;Affect;Affinity;Alleles;Binding;Blood;Body Size;bone;Bone Development;Bone Marrow;bone mass;Bone Tissue;bone turnover;BTB/POZ Domain;causal variant;Cell Differentiation process;Cells;Child;Childhood;Chronic Disease;Clinical;conditional knockout;Coupled;CRISPR/Cas technology;Data;dentin matrix protein 1;Diagnosis;Drug or chemical Tissue Distribution;Embryo;Enzyme-Linked Immunosorbent Assay;Exhibits;Fatty Liver;fetal;Functional disorder;Future;Genes;Genetic Diseases;Genetic Screening;Germ Lines;Goals;Growth;Growth and Development function;Growth Disorders;Histologic;Human;IGF-1 Signaling Pathway;Impairment;Infant Development;insight;Insulin Resistance;insulin signaling;Insulin-Like Growth Factor I;Investigation;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Life;Light;Link;Lipodystrophy;loss of function mutation;LoxP-flanked allele;Maps;Mass Spectrum Analysis;Measures;Mediating;Mediator;Meiosis;mesenchymal stromal cell;Metabolic;metabolic phenotype;Modeling;Molecular;Mus;mutant;Mutant Strains Mice;Mutation;N-terminal;Names;new therapeutic target;novel;novel therapeutic intervention;osteoblast differentiation;Osteoblasts;Osteogenesis;osteogenic;Pathogenesis;Pathologic;Patients;Performance;Phenotype;Physiological;PIK3CG gene;Play;positional cloning;Procollagen;Protein Isoforms;Proteins;Psyche structure;Recurrence;Regulation;Reiterated Genes;reproductive;Research;Risk;Role;screening;SHORT syndrome;Signal Pathway;Signal Transduction;skeletal;skeletal abnormality;Skeletal Development;Speed;Stromal Cells;Syndrome;tartrate-resistant acid phosphatase;Techniques;Testing;Time;Translating;Ubiquitination;Work

PROJECT_TITLE: The Role of KBTBD2 in Bone Development and SHORT Syndrome

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: Functional electrical stimulation (FES) is the use of small electrical currents applied to the nervous system to replace or compensate for the actions of neurons that have been damaged by injury or disease. The Center for Functional Electrical Stimulation (FES Center) maintains a rich environment that promotes new discoveries and provides the critical resources needed for innovation. It develops new, FES-based rehabilitation treatments for Veterans and civilians with neurological disorders such as spinal cord injury, stroke, Parkinson's disease, chronic pain, psychiatric disorders, epilepsy, and internal body functions such as bladder and bowel function, blood pressure, and inflammation. FES Center investigators (1) explore approaches for interfacing with the nervous system, (2) develop new stimulation technologies, (3) establish teams of scientist, engineers, and clinicians who explore the effectiveness and practicality of the FES treatments, and (4) work to move effective new FES treatment into clinical deployment.

PI_NAMEs: KIRSCH, ROBERT F. (contact);RIECHERS, RONALD G

PROJECT_TERMS: Address;Bioethics;Bladder;Blood Pressure;brain health;chronic pain;Clinic;Clinical;Clinical Trials;Collaborations;Communities;community building;community-centered;Compensation;computerized tools;Creativeness;Development;Devices;Disease;Effectiveness;Engineering;Environment;Epilepsy;Equipment;Event;Fostering;functional electrical stimulation;Home;improved;Individual;Industry;Inflammation;Infrastructure;Injury;innovation;Institution;Interdisciplinary Study;interest;Intervention;intervention effect;Intestines;Laboratories;Language;Leadership;Machine Learning;Medical center;Medical Illustration;member;Mental disorders;Mission;models and simulation;Movement;Needs Assessment;Nervous System;Nervous System Disorder;neural;Neurologic;Neurons;Neurophysiology - biologic function;neuroregulation;novel;Pain;Parkinson Disease;patient population;Persons;Physiology;Rehabilitation Outcome;rehabilitation research;Rehabilitation therapy;Research;research and development;Research Personnel;Resource Sharing;Resources;restoration;Scientist;Services;social;Spinal cord injury;Stroke;success;synergism;System;Talents;Techniques;Technology;technology development;translational research program;Translations;United States Department of Veterans Affairs;Universities;University Hospitals;Veterans;Vision;Work

PROJECT_TITLE: VA RR&D Center for Functional Electrical Stimulation (FES)

STUDY_SECTION: RRDC

STUDY_SECTION_NAME: Centers, Research Enhancement Award Program and Consortiums[RRDC]


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Research conducted at the National Center for Rehabilitative Auditory Research (NCRAR) involves the diagnosis and assessment, rehabilitation and prevention of auditory and balance dysfunction. It is highly relevant to Veterans' health care because tinnitus and hearing loss are the number one and number two most prevalent service-connected disabilities, respectively, among all Veteran compensation recipients (Veterans Benefits Administration, 2019). Moreover, balance dysfunction is associated with blast exposure and traumatic brain injury often seen in Veterans of recent conflicts. Additionally, since nearly half of all Veterans are over age 65 (VA Strategic Plan 2018-2024), NCRAR research will remain relevant to Veterans' health because it focuses on the assessment and diagnosis, rehabilitation, and prevention of tinnitus, hearing loss and balance dysfunction, which are all disorders prevalent in aging Veterans.

PI_NAMEs: FEENEY, MARTIN PATRICK (contact);KONRAD-MARTIN, DAWN L

PROJECT_TERMS: Acclimatization;active duty;Adult;Aging;aminoglycoside-induced ototoxicity;Area;Audiology;Auditory;behavior test;Biological Markers;blast exposure;Brain;Brain Injuries;chemotherapy;Clinic;clinical phenotype;Clinical Trials;Cochlea;Cognition;Collaborations;commercialization;Communication;Compensation;Computers;Data;Development;Diagnosis;disability;Disease;Drug Prescriptions;Education and Outreach;Effectiveness;Electrophysiology (science);Epidemiology;equilibration disorder;Equilibrium;Evaluation;externship;Frequencies;Functional disorder;Funding;Genetic Markers;handheld mobile device;Health;Healthcare;Healthcare Systems;Hearing;Hearing Aids;hearing impairment;hearing screening;hidden hearing loss;Home;human old age (65+);improved;Infrastructure;Legal patent;Military Personnel;Modeling;monitoring device;Musculoskeletal Equilibrium;Noise;Noise-Induced Hearing Loss;normal hearing;Older Population;otoacoustic emission;otoprotectant;ototoxicity;Outer Hair Cells;outreach program;Peer Review;Perception;Physiological;Population;portability;Post-Traumatic Stress Disorders;Prevention;primary care setting;Primary Prevention;Psychoacoustics;psychologic;randomized, clinical trials;Rehabilitation Centers;Rehabilitation therapy;Research;Research Personnel;Research Training;Sensory;Sensory Aids;Series;service member;Services;Site;somatosensory;sound;Speech;Strategic Planning;Stream;Students;success;symposium;System;Tablets;Technology;Testing;Time;Tinnitus;Translational Research;Traumatic Brain Injury;United States National Institutes of Health;vestibular system;Veterans;Visual


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: CAMBRIDGE

ORG_NAME: KYTOPEN CORP

ORG_STATE: MA

PHR: PROJECT NARRATIVE Natural killer (NK) cells represent a high impact cellular target for gene therapy, but due to limitations in current methodologies for gene delivery, NK cells remain a largely untapped resource. Here, we propose that non-viral delivery via our Flowfect™ platform can alleviate this limitation on NK genetic modification at both research and large scale needed for pre-clinical studies. Due to the major potential impact NK cells represent in the clinical setting, non-viral Cas9 ribonucleoprotein gene knockout will allow for unrestricted therapeutic applications in viral immunity, autoimmunity, and cancer immuno-surveillance.

PI_NAMEs: CHIU, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Acceleration;Acute Myelocytic Leukemia;Address;Adoptive Cell Transfers;American;Antibodies;Autoimmune Diseases;Autoimmunity;Autologous;Biological;cancer cell;Cell Physiology;Cell surface;Cell Survival;Cell Therapy;Cells;cellular targeting;chimeric antigen receptor;Clinical;Clinical Trials;clinically relevant;Combined Modality Therapy;CRISPR/Cas technology;cytotoxic;cytotoxicity;Devices;Dose;electric field;Electroporation;engineered NK cell;Engineering;Exhibits;fluid flow;Funding;Gene Delivery;gene editing technology;Gene Modified;gene therapy;gene-targeted therapy;Genes;Genetic;Goals;Health;Human;Immune;Immunity;Immunologic Surveillance;Immunotherapy;improved;In Vitro;in vivo;Infusion procedures;interest;Knock-out;knockout gene;Libraries;Liquid substance;Malignant Neoplasms;Mediating;meetings;Membrane Proteins;Messenger RNA;Methodology;Methods;Modeling;Modification;mouse model;Mus;Natural Killer Cells;NCAM1 gene;Neoplasm Metastasis;NK cell therapy;novel;novel strategies;nucleic acid delivery;Nucleic Acids;Patients;Phase;Phenotype;Population;pre-clinical research;preclinical development;preclinical study;Production;receptor;Reporter;Reporting;Reproducibility;Research;Resources;response;Ribonucleoproteins;rituximab;Scientist;screening;Small Business Innovation Research Grant;Stimulus;success;Surface;Survival Rate;System;T-Lymphocyte;Technology;Testing;Therapeutic;therapeutic target;Toxic effect;transcriptome;Transfection;Translating;tumor microenvironment;Validation;Viral;Viral Vector

PROJECT_TITLE: Non-Activated Natural Killer Cell Engineering For Enhanced Cytotoxic Potential

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-R(10)B]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR/STTR CONTRACTS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UTTER THERAPEUTICS INC.

PI_NAMEs: CHARYCH, DEBORAH  (contact)

PROJECT_TERMS: adaptive immunity;Award;Biological;CAR T cell therapy;Chemistry;Child;Childhood;Childhood Brain Stem Neoplasm;Clinical Research;Clinical Trials;cytokine;Diffuse intrinsic pontine glioma;Drug Kinetics;Engineering;Failure;Future;GD2 Binding;Human;IL12RB1 gene;Immune;Immunologic Stimulation;Immunotherapy;Interleukin-12;interleukin-12 receptor;Libraries;manufacture;Molecular Weight;Natural Immunity;Patients;Penetration;peptidomimetics;Phase;Proteins;screening;Signal Transduction;systemic toxicity;Therapeutic;tool;tumor

PROJECT_TITLE: Phase I Therapeutic Award - Developing Split, Conditionally Active Peptidomimetics of IL-12 For the Treatment of Rare Pediatric DIPG


NIH_SPENDING_CATS: Cancer;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: PLAINSBORO

ORG_NAME: ATUX ISKAY GROUP LLC

ORG_STATE: NJ

PI_NAMEs: OHLMEYER, MICHAEL  (contact)

PROJECT_TERMS: addiction;Animals;anti-cancer;Award;Cell model;Child;efficacy evaluation;Genetic Transcription;improved;inhibitor;Lead;Mediating;mouse model;MYCN gene;Neuroblastoma;novel;novel therapeutic intervention;Oncogenic;Outcome;patient subsets;Phosphorylation;programs;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;Refractory;Relapse;Research;RNA Polymerase II;scale up;Small Business Innovation Research Grant;small molecule;Sulfonamides;Sulfonylurea Compounds;Therapeutic;tumor;tumor growth;Tumor Suppressor Proteins

PROJECT_TITLE: SBIR CONCEPT AWARD - THERAPEUTICS - SULFONYL-UREA AND SULFONAMIDE PP2A ACTIVATORS AS MYCN AMPLIFIED NEUROBLASTOMA (NBL) THERAPEUTICS


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Gene Therapy;Genetics;Nanotechnology;Orphan Drug;Rare Diseases

ORG_CITY: AUSTIN

ORG_NAME: QANA THERAPEUTICS INC.

PI_NAMEs: GRAHAM, JAMES B. (contact)

PROJECT_TERMS: Adrenal Cortex;Adrenocortical Carcinoma;Award;Cell Death;Cell Line;cell type;Cholesterol Esters;Development;Encapsulated;Exhibits;Formulation;High Density Lipoproteins;In Vitro;Integral Membrane Protein;Iron;Malignant Epithelial Cell;Malignant Neoplasms;Metabolic;Modeling;mouse model;nanoparticle;neoplastic cell;novel;novel therapeutic intervention;Predisposition;Recurrence;Research Activity;Role;Small Business Innovation Research Grant;SR-B proteins;Surface;Survival Rate;targeted delivery;Therapeutic Effect;therapeutic target;treatment response;tumor;uptake;Work

PROJECT_TITLE: SBIR CONCEPT AWARD "THERAPEUTICS" - TARGETED DELIVERY OF FERROPTOSIS INDUCERS FOR TREATMENT OF ADRENOCORTICAL CARCINOMA


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Narrative The parental project validates our hypothesis that when loaded with the same guide RNA, four human Argonaute proteins recognize the same target differently, causing distinct gene suppression outcomes. The binding kinetics and affinity of each AGO-RISC for the same target have not been characterized and need measurement with a dedicated system. The requested Octet R2 system will enable us to analyze and compare these aspects across the four homologs, providing initial insights into the target specificity of the four human RISCs.

PI_NAMEs: NAKANISHI, KOTARO  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 5' Untranslated Regions;Acylation;Affinity;Algorithms;Amino Acids;Anti-viral Response;base;Binding;Binding Proteins;Binding Sites;Biological Assay;Biological Process;Cells;Chimera organism;Complex;Cryoelectron Microscopy;Dedications;design;Designer Drugs;Development;Disease;Dissociation;Drug Design;Equipment and supply inventories;Eukaryotic Cell;Event;experimental study;flexibility;Foundations;Funding;Gene Expression;Gene Silencing;Genes;Goals;Guide RNA;HIV;Homologous Gene;Human;hydroxyl group;Hydroxyl Radical;Immunoprecipitation;improved;Individual;insight;Internal Ribosome Entry Site;Investigation;Kinetics;Knowledge;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Messenger RNA;Methods;MicroRNAs;Molecular;Molecular Conformation;mutant;N-methylisatoic anhydride;neurodevelopment;novel;novel therapeutic intervention;Nucleotides;Outcome;Outcome Study;parent project;prediction algorithm;Primer Extension;Property;Proteins;Resolution;RNA;RNA Binding;RNA Interference;RNA purification;RNA-Induced Silencing Complex;Role;scaffold;Shapes;Site;Solid;Specificity;Structure;System;Techniques;Testing;Therapeutic;transcriptome sequencing;Translational Repression;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Target specificity of human RNA-induced silencing complex


ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE In all animals, the fertilized egg undergoes regulation of the maternally deposited instructions (mRNAs and proteins) and activation of its own genome. This project studies how the vertebrate embryo organizes multiple players to undertake these tasks, with the goal of understanding basic conserved principles of how genes are regulated that can be applied to other systems, including reprogramming of the cellular fates and cancer.

PI_NAMEs: GIRALDEZ, ANTONIO J (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Affect;aged;Animals;Biological Assay;Cell Reprogramming;Cells;Chromatin Structure;Code;Deposition;Development;DNA;early pregnancy loss;Embryo;Embryonic Development;experimental study;Fertilization in Vitro;Gene Expression;gene regulatory network;Genes;Genetic Transcription;Genome;Goals;Human;human disease;imaging approach;in vivo;Individual;Infertility;insight;Instruction;Malignant Neoplasms;Maps;Maternal Messenger RNA;Mediating;Messenger RNA;Molecular;mRNA Decay;mRNA Stability;novel;Oncogene Activation;Output;Pathway interactions;Play;post pregnancy;Post-Transcriptional Regulation;Pregnancy;Process;programs;Proteins;Public Health;Reader;Regulation;Reporter;Repression;reproductive;Reproductive Health;RNA;Role;Shapes;Structure;System;tool development;Translational Regulation;vertebrate embryos;Woman;zygote

PROJECT_TITLE: Molecular mechanisms of the maternal to zygotic transition


ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: Narrative The biological significance of protein assemblies in both health and disease makes understanding the molecular underpinnings of their molecular motions and interactions essential for intervention. Protein interactions with collagen fibrils are critical for healthy cellular function, self-assembly of intrinsically disordered α-synuclein monomers leads to pathological oligomer and fibril formation associated with Parkinson’s Disease, and interactions of the SARS-CoV-2 spike glycoprotein mediate host cell entry. By integrating solution NMR with other biophysical tools and cellular assays, our studies will reveal mechanisms that underlie these protein– protein interactions and will inform design of therapeutics to encourage functional or discourage pathological interactions.

PI_NAMEs: BAUM, JEAN S (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: ACE2;Address;Affect;alpha synuclein;Amyloid deposition;Amyloid Fibrils;Biological;biophysical properties;biophysical tools;Biophysics;Cell Physiology;Cells;Cellular Assay;Collagen Fibril;Complex;Computing Methodologies;design;Disease;dynamic system;Event;Fibrillar Collagen;Goals;Health;Homeostasis;instrumentation;Intervention;Lewy Bodies;Measures;Mediating;Molecular;Molecular Conformation;monomer;Motion;nanoscale;Parkinson Disease;Pathologic;Platelet aggregation;Property;Protein Dynamics;protein protein interaction;Proteins;Reader;receptor binding;SARS-CoV-2 spike protein;self assembly;solid state nuclear magnetic resonance;synucleinopathy;System;Therapeutic

PROJECT_TITLE: Acquisition of a FLUOstar Omega plate reader


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

ORG_CITY: CARBONDALE

ORG_NAME: SOUTHERN ILLINOIS UNIVERSITY CARBONDALE

ORG_STATE: IL

PHR: Project Narrative The ability to synthesize new asymmetric molecular structures, with selective and precise control over spatial arrangements of its atoms, is the primary requirement for life-saving drug discovery. The proposed research will use solid molecular frameworks as readily scalable and separable photocatalysts to drive spatially selective reactions by hosting the reactive intermediates within their precisely designed asymmetric pores. We anticipate the research on developing selective heterogeneous photocatalysis will have both fundamental chemical and biochemical scientific impacts as well as practical impacts in new drug discovery.

PI_NAMEs: DERIA, PRAVAS  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Bioinspired selective heterogeneous organic photoredox catalysis


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MOUNT PLEASANT

ORG_DEPT: BIOLOGY

ORG_NAME: CENTRAL MICHIGAN UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative The proposed research is relevant to human health because the elucidation of evolutionarily conserved mechanisms that promote multipotent cell fate during quiescence is expected to advance the field of stem cell biology. The proposed work will illuminate a novel pathway involving FOXO transcription factors and RNA-binding proteins that are conserved from C. elegans to mammals. These factors are key regulators of stem cell fate across species. The project is relevant to the mission of NIH and NIGMS because it is expected to provide fundamental knowledge about stem cell biology and to lay the foundation for clinical applications.

PI_NAMEs: KARP, XANTHA  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Address;Adopted;Adult;Caenorhabditis elegans;Cell division;Cell Fate Control;Cell Maintenance;Cells;Characteristics;clinical application;Data;Development;Dissection;experimental study;Family;fly;Foundations;gain of function;Genes;Genetic;Genetic Transcription;Goals;Health;Human;in vivo;innovation;Knowledge;Larva;loss of function;Mammals;Messenger RNA;Mission;multipotent cell;National Institute of General Medical Sciences;novel;Orthologous Gene;Pathway interactions;Pattern;preservation;Proliferating;promoter;Proteins;Regulation;Reporter;Research;Resolution;response;RNA-Binding Proteins;self renewing cell;stem cell biology;stem cell fate;stem cell function;stem cell model;stem cells;System;Testing;transcription factor;Transcriptional Regulation;United States National Institutes of Health;Work

PROJECT_TITLE: Regulation of stem cell fate by FOXO and RNA binding proteins


NIH_SPENDING_CATS: Biomedical Imaging

ORG_CITY: JACKSON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Narrative The mission of the Molecular Center of Health and Disease (MCHD)-COBRE is to employ innovative molecular and physiological approaches to study the health and disease continuum. The purchase of new AmiHTX in vivo animal imaging system will replace the current 15-year-old IVIS Spectrum Imager to allow for higher resolution imaging and data analysis capabilities that will help achieve the mission and goals of the MCHD.

PI_NAMEs: GARRETT, MICHAEL R (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: 15 year old;Administrative Supplement;Age;animal imaging;Award;Bioinformatics;Biomedical Research;Biometry;Centers of Research Excellence;Communities;Core Facility;Data Analyses;Data Set;Detection;Disease;Disease Progression;Equipment;equipment acquisition;Funding;Future;Genes;Goals;Health;high resolution imaging;imager;imaging system;in vivo;in vivo imaging system;Infrastructure;innovation;insight;Institution;instrument;instrumentation;interest;Mission;Molecular;National Institute of General Medical Sciences;pathogen;Physiological;Research;Research Personnel;Research Project Grants;Resources;Services;tool;Update;Whole Organism;X-Ray Medical Imaging

PROJECT_TITLE: Molecular Center of Health and Disease


NIH_SPENDING_CATS: Neurosciences;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative: Neurodevelopmental disorders, including microcephaly and autism, as well as neurodegenerative diseases, including Alzheimer’s, and cancer result in significant human suffering and impose significant annual costs on the US health care system and society as a whole. This proposal seeks to understand how diet influences neural stem cell proliferation decisions during development. Neural stem cells are the cells that make all the neurons in the brain.

PI_NAMEs: SIEGRIST, SARAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Adult;Affect;Alzheimer's Disease;autism spectrum disorder;Behavior;Brain;Cell division;cell type;Cells;Complex;Consumption;cost;Dependence;Development;Diet;dietary;Disease;Drosophila genus;Drosophila melanogaster;Genetic;Goals;Healthcare Systems;Human;insight;Intrinsic factor;Learning;Location;Malignant Neoplasms;Maps;mature animal;Memory;Microcephaly;model organism;Molecular;Morphology;nerve stem cell;neural circuit;neuroblast;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;neuroregulation;Nutrient;Nutrient availability;Pathway interactions;PIK3CG gene;Population Heterogeneity;programs;Proliferating;Research;response;Series;single cell sequencing;Societies;Specific qualifier value;stem cell proliferation;Stem Cell Research;Techniques;Time;transcription factor

PROJECT_TITLE: Nutrient-dependent regulation of neural stem cell proliferation and neural circuit formation


ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative  Ubiquitin is a post-translational modification that regulates diverse cellular processes and its dysregulation is associated with many human diseases ranging from neurodegeneration to cancer. Here, we propose research directions that will result in a deeper understanding of how ubiquitin networks are regulated during conditions of stress to facilitate the cellular adaptive response. Dissecting these mechanisms will provide a platform for long-term exploration of ubiquitin networks as potential therapeutic targets in the treatment of human diseases.

PI_NAMEs: MACGURN, JASON A (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Amino Acids;Binding Proteins;Biochemical;biological adaptation to stress;Biology;blood glucose regulation;cancer type;Cell Physiology;Cells;Cellular Stress;Code;Elements;Enzymes;Eukaryotic Cell;Family;Genetic;Glucose Transporter;Human;human disease;insight;Investigation;Length;Malignant Neoplasms;Membrane;Modification;Nerve Degeneration;Pathway interactions;Peptides;Phosphorylation;Phosphotransferases;Polymers;Positioning Attribute;Post-Translational Protein Processing;protein degradation;protein protein interaction;Proteins;Proteomics;proteostasis;Quality Control;Regulation;Research;response;Signal Transduction;SLC2A1 gene;Stress;Syndrome;therapeutic target;trafficking;Ubiquitin;Work;Writing;Yeasts

PROJECT_TITLE: Deciphering the ubiquitin code in stress signaling and membrane trafficking


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: BOONE

ORG_NAME: APPALACHIAN STATE UNIVERSITY

ORG_STATE: NC

PHR: This administrative supplement is to fund the purchase of fast protein liquid chromatography (FPLC) equipment to aid purification of protein produced recombinantly and used for in vitro research studies. Significant quantities and high purity protein are necessary for experiments regarding the nature of cytochrome P450 enzymes and their roles in generating endogenous hormones and steroids key to regulating human health. The new instrument will allow more types of experiments to be performed than possible with our current equipment and for all work requiring these proteins to be performed more rapidly.

PI_NAMEs: REDDISH, MICHAEL JERRELL (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: activation-induced cytidine deaminase;Administrative Supplement;Biological Sciences;Cytochrome P450;Enzymes;Equipment;experimental study;Family;fast protein liquid chromatography;Funding;Health;Hormones;Human;In Vitro;instrument;Molecular Sieve Chromatography;Nature;parent project;Production;protein purification;Proteins;Recombinant Proteins;Recombinants;research study;Resolution;Role;Steroids;Structure;Techniques;Work

PROJECT_TITLE: Structure-Function Studies of the Human Cytochrome P450 27 Family


NIH_SPENDING_CATS: Genetics

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative  Pioneer transcription factors can bind and open silent chromatin, leading to transcriptional activation. The pioneer factors Sox2 and Oct4 orchestrate cell-fate changes during development, yet how they selectively target and destabilize closed chromatin remains largely unknown. This project will investigate the molecular details of how Sox2 and Oct4 alter the structure and epigenetic state of chromatin, which will advance our mechanistic understanding of pioneering action and ability to manipulate stem cells for research and disease therapy.

PI_NAMEs: NIKOLOVA, EVGENIA NIKOLAEVNA (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;adult neurogenesis;Affect;Binding;Biological Assay;Cells;Chemicals;Chromatin;cofactor;Collaborations;Dependence;Development;Disease;DNA;DNA Sequence;DNA-Binding Proteins;Embryonic Development;Enzymes;Epigenetic Process;Future;Gene Activation;Gene Expression;genetic regulatory protein;Genome;Goals;histone methyltransferase;Histones;improved;In Vitro;in vivo;insight;Investigation;link protein;Malignant Neoplasms;Mediating;Methods;Modification;Molecular;Molecular Conformation;Mutation;Nervous System Disorder;NMR Spectroscopy;novel therapeutic intervention;Nuclear Magnetic Resonance;Nucleosomes;pluripotency;Positioning Attribute;Protein Dynamics;Regulation;Resolution;Role;Site;Somatic Cell;Stem Cell Research;Structure;Tail;therapeutic target;transcription factor;Transcriptional Activation;Variant;Work

PROJECT_TITLE: Dissecting the Mechanisms of Pioneer Factor Facilitated Chromatin Opening

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ORG_CITY: ATHENS

ORG_NAME: OHIO UNIVERSITY ATHENS

PHR: Project Narra+ve The increasing number of bacterial infec3ons which are resistant to current medicines is crea3ng a signiﬁcant threat to human health. This supplemental award will replace a malfunc3oning old instrument to help ensure the success of the parent award. In the parent award, a predominantly undergraduate research team will design, make and test molecules aimed at disrup3ng a unique regulator in bacteria. The outcomes from this project will help in the design and development of new an3bacterial medicines and will also lead to the training of future biomedical research scien3sts who are inspired to discover solu3ons for tomorrow’s public health.

PI_NAMEs: HINES, JENNIFER V (contact)

PROJECT_TERMS: 14 year old;Achievement;Anti-Bacterial Agents;anti-cancer;Antibiotics;Award;Bacteria;Bacterial Drug Resistance;Bacterial Infections;Binding;Biological Assay;Biomedical Research;career;Chemicals;Computing Methodologies;design;Development;drug discovery;Drug Targeting;Elements;Ensure;Equipment;Essential Genes;experience;Future;global health;Gram-Positive Bacteria;Health;high throughput screening;Human;improved;Infection;inhibitor;innovation;instrument;Knowledge;Medicine;next generation;novel;Outcome;parent project;Pathogenicity;Process;Public Health;rational design;Reader;Request for Proposals;Research;Resistance;RNA;RNA Binding;small molecule;success;Testing;Therapeutic Agents;Training;Transfer RNA;undergraduate research;undergraduate student;Untranslated RNA;Viral

PROJECT_TITLE: R15 AREA: Optimizing allosteric modulation of noncoding regulatory RNA function


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Depression;HIV/AIDS;Mental Health;Mental Illness;Neurosciences

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE We propose to investigate systemic inflammation, blood-brain-barrier (BBB) permeability, and reward functions in the study of comorbid depression in people with HIV (PWH), a group heavily impacted by depression and its health consequences. This collaborative proposal bridges disciplines of psychiatry, neuroimaging, HIV, and immunology in an effort to improve our understanding of neural mechanisms underlying depression in PWH and has the potential to improve overall and mental health outcomes in this highly vulnerable group.

PI_NAMEs: BERMAN, JOAN WEINBERGER;GABBAY, VILMA  (contact);SHARMA, ANJALI

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Address;Anhedonia;Anterior;Anxiety;arterial spin labeling;Astrocytes;Biological Response Modifiers;Blood;Blood - brain barrier anatomy;Blood specimen;blood-brain barrier crossing;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;brain endothelial cell;burden of illness;causal model;CD4 Lymphocyte Count;Cell Separation;Cells;chemokine;Chronic;clinically relevant;Coculture Techniques;Cognition;cohort;comorbid depression;computerized;contrast enhanced;Corpus striatum structure;cytokine;Data;Depressed mood;Depressive disorder;depressive symptoms;design;Development;Discipline;Evaluation;Exhibits;Flow Cytometry;Functional Magnetic Resonance Imaging;graph theory;Health;Heterogeneity;HIV;HIV Infections;HIV Seronegativity;Human;Immune;Immunology;Immunology procedure;Impairment;improved;In Vitro;in vitro Model;in vivo;indexing;Inflammation;Lead;Learning;Machine Learning;Magnetic Resonance Imaging;Measures;Mediating;Mental Depression;Mental Health;migration;Modeling;neural circuit;neurobiological mechanism;neuroimaging;neuroinflammation;neuromechanism;neuropsychiatry;novel;Nucleus Accumbens;Outcome;Participant;Pathogenesis;Peripheral;Peripheral Blood Mononuclear Cell;Permeability;Persons;Phase;Prevalence;Procedures;Process;Psychiatry;Psychopathology;Reporting;Reproducibility;Research;response;Rest;reward anticipation;reward circuitry;reward dysfunction;Rewards;Role;Sampling Studies;Severities;Side;subthreshold depression;suicidal;systemic inflammatory response;targeted treatment;Testing;Trauma;Ventral Tegmental Area;Viral;Viral Load result;Vulnerable Populations;Water;Youth

PROJECT_TITLE: Inflammation, BBB disruption, and Reward Function in the Pathogenesis of Depression among PWH


PHR: Project Narrative: This discovery project will discover the physical forces dictating the native conformations of membrane proteins and their interactions with lipid bilayers. The knowledge gained from this research will contribute to the mechanisms of protein misfolding diseases, enable the rational design of therapeutics to modulate protein conformations, will be useful in the computational modeling of protein structures, and provides a biophysical and chemical basis for the design of proteins with novel functions.

PI_NAMEs: FLEMING, KAREN G. (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Biology;Biophysics;Catalysis;Chemicals;Computational algorithm;Computer Models;Databases;Disease;driving force;Equilibrium;Hydrogen Bonding;Investigation;Knowledge;Lipid Bilayers;Membrane Proteins;Modeling;Molecular;Molecular Conformation;novel;Phospholipids;Physical Chemistry;Protein Conformation;Protein Engineering;protein folding;protein misfolding;protein structure;Proteins;rational design;Research;simulation;Solvents;Structure;Therapeutic;Training;Vertebral column;Water

PROJECT_TITLE: Forces Driving Membrane Protein Folds


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: NORMAN

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: Project Narrative: An administrative supplement is requested to support the purchase of a state-of-the-art flow cytometer (Cytek Aurora 4 laser with small particle detector) for high-content analysis of immune cells and immune-cell secreted extracellular vesicles. The equipment will significantly elevate the immunoengineering and inflammation work, both in the PI’s currently funded NIH NIGMS project and the University of Oklahoma at large, as the institution does not currently possess an equivalent instrument. If funded, the PI commits to making the equipment available to the University of Oklahoma (OU) research community via an established core facility model (Immunoengineering Core), and to encourage expanded equipment use through focused trainings or technical workshops at OU.

PI_NAMEs: CLEGG, JOHN R (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acceleration;Achievement;Administrative Supplement;Antigens;Area;Award;base;Biological;Brain;Brain Injuries;Budgets;career;cell analyzer;Cell Communication;Cell secretion;Cells;Central Nervous System;Characteristics;Collaborations;Committee Members;Communication;Communication Research;Communities;Contracts;Core Facility;design;Detection;Devices;Direct Costs;Disease;Distant;Drug Delivery Systems;Drug Targeting;Educational workshop;Engineering;Ensure;Equipment;equipment acquisition;Evaluation;experimental study;extracellular;extracellular vesicles;Extramural Activities;Fees;Flow Cytometry;Fluorescence;fluorophore;Funding;Future;Goals;Health Sciences;Home;Immune;immune activation;immunoengineering;Immunologics;Immunophenotyping;Infiltration;Inflammation;Inflammatory;Institution;instrument;instrumentation;Laboratories;Lasers;Letters;Link;Macrophage;Maintenance;Manufacturer;Measures;Medical;Medical Research;Modeling;Molecular Conformation;Myeloid Cell Activation;Myeloid Cells;nanoscale;National Institute of General Medical Sciences;neuroinflammation;Oklahoma;optical spectra;Optics;Outcome;particle;particle detector;Peripheral;Phenotype;Preparation;preservation;Principal Investigator;programs;Proteins;Research;Research Personnel;Research Project Grants;Research Support;Role;Running;Science;Scientist;Surface;Suspensions;Techniques;Technology;Tissues;Training;United States National Institutes of Health;Universities;Viola;Work

PROJECT_TITLE: Acquisition of a Spectral Flow Cytometer with Small Particle Detection, for Neuroinflammation and Immunoengineering Applications


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: CHARLESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative  There will be no change in the parent grant resulting from this proposed supplement. Common neurodevelopmental disorders (NDDs), including autism spectrum disorders, attention-deficit and hyperactivity disorder, intellectual disability, seizure disorders, and traumatic injury to the developing brain all have major social and economic costs associated. This initiative will establish a center of research excellence in Neurodevelopment and Its Disorders in South Carolina that will ultimately improve the health and well-being of individuals diagnosed with NDDs.

PI_NAMEs: COWAN, CHRISTOPHER W (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Administrative Supplement;Area;Attention deficit hyperactivity disorder;autism spectrum disorder;Basic Science;Behavioral;behavioral phenotyping;Bioinformatics;Biology;Brain;career;Centers of Research Excellence;Clinical;Clinical Research;Collaborations;college;Complement;computer infrastructure;Department chair;Diagnosis;Disease;economic cost;Epilepsy;Equipment;Evaluation;experience;Fostering;Funding;Future;Genomics;Goals;Grant;Health;Impaired cognition;improved;Individual;individuals with autism spectrum disorder;innovation;Institution;Intellectual functioning disability;Interdisciplinary Study;Investments;Medical;Medicine;Mentors;Mission;Modernization;Molecular Neurobiology;multidisciplinary;Mus;neurodevelopment;Neurodevelopmental Disorder;parent grant;Peer Review;Personal Satisfaction;Pilot Projects;programs;Psychologist;Research;research and development;Research Personnel;Research Project Grants;Resources;Scientist;social;Source;South Carolina;Training;training opportunity;Translational Research;Traumatic injury;United States National Institutes of Health;Universities

PROJECT_TITLE: CNDD Administrative Supplement for Equipment


ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: The Center for Biomolecular Structure and Dynamics (CBSD), an NIH Center of Biomedical Research Excellence, supports research programs that use biophysical and structural biology methods to understand the underlying mechanisms of normal and pathological physiological processes. This proposal will fund the instrumentation-intensive research core facilities necessary to conduct this research and programs designed to sustain the center over the long term so that CBSD researchers can continue to lay the groundwork to discover new therapies for the treatment of human pathogens, diabetes, neurodegenerative diseases, and cancer.

PI_NAMEs: BOWLER, BRUCE E (contact)

PROJECT_TERMS: Acceleration;Applications Grants;Area;Award;base;Basic Science;Biological Process;Biomimetics;Biophysics;Budgets;career;cellular imaging;Centers of Research Excellence;Charge;cohort;college;Communities;Computational Biology;Core Facility;Counseling;Cryoelectron Microscopy;design;Development;Diabetes Mellitus;Disease;Docking;drug development;drug discovery;Educational workshop;Ensure;Equipment;Evolution;Extramural Activities;Faculty;Fees;Financial Support;Fluorescence;Fostering;Foundations;Funding;Future;Genes;Genetic Transcription;Goals;Grant;Grant Review;Growth;Health;Human;human pathogen;Humanities;Image;imaging capabilities;Imaging Techniques;in vivo;Incentives;Infrastructure;Institution;instrumentation;Investments;Laboratory Research;Ligands;macromolecule;Malignant Neoplasms;Mass Spectrum Analysis;Mathematical Biology;member;Mentors;metabolomics;Methods;Mission;Modernization;Molecular;Molecular Computations;molecular dynamics;Monitor;Montana;Neurodegenerative Disorders;novel therapeutics;Pathologic;Peer Review;Phase;Physiological Processes;Pilot Projects;Positioning Attribute;programs;protein expression;Proteomics;Publications;receptor;Research;research facility;Research Personnel;Research Support;Resolution;Resources;Role;Sampling;Science;Services;single molecule;small molecule;structural biology;Structural Chemistry;Structure;success;Translational Research;two-dimensional;United States National Institutes of Health;Universities;Water;Work;Writing

PROJECT_TITLE: Biomolecular Structure and Dynamics: Equipment Supplement for PEAQ-ITC


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Clinical Research;Data Science;Genetics;Networking and Information Technology R&D (NITRD)

ORG_CITY: LARAMIE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: The Wyoming INBRE Building Cloud-based Learning Module project will contribute to the NIH IDeA goal of training students and investigators how to access and analyze large and complex datasets. This project will focus on training in the wide-ranging and impactful use of RADseq data and demonstrating the power of RADseq datasets to answer important biological questions.

PI_NAMEs: SEVILLE, ROBERT SCOTT (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Biological;Biology;Biomedical Research;Chromosome Mapping;cloud based;Collaborations;college;Communities;complex data;Data;Data Science;Data Science Core;Data Set;Future;Genetic;genome wide association study;genomic data;Goals;improved;Infrastructure;insight;interest;Journals;Learning;Learning Module;literacy;Livestock;member;National Institute of General Medical Sciences;Pathway interactions;Peer Review;Phase;Population Genetics;Publishing;Research Personnel;science education;student training;symposium;Teacher Professional Development;Training;United States National Institutes of Health;Universities;web site;Wyoming

PROJECT_TITLE: Wyoming IDeA Networks for Biomedical Research Excellence Phase 4


ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Microbial communities relevant for human health are often dense, spatially structured, and interact both chemically and physically, for example by releasing toxins to prevent infection by external colonizing pathogens and building localized pressure to penetrate soft tissues. Our work will reveal the impact of mechanics and microbial antagonism on the evolutionary trajectories of microbial communities and will help us understand how spatial constraints impose selective pressures that lead to the increased invasiveness of microbial infections. By investigating the factors required for the successful replacement of a microbial strain by an invading antagonist, our results will help design better strategies for microbiome engineering and microbial replacement therapies.

PI_NAMEs: GIOMETTO, ANDREA  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Evolutionary dynamics of dense, spatially structured, and antagonistic microbial populations


ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: Public Health Relevance/Narrative The proposed research seeks to develop the direct delivery of recombinant dCas9-histone demethylase protein complex to induce frataxin gene-targeted histone demethylation and DNA repair-mediated GAA repeat contraction in Friedreich's ataxia using human vault nanoparticles. The research will open a novel avenue for gene therapy for Friedreich's ataxia using human natural bionanoparticles. Thus, it directly relates to the NIH's mission of reducing illness and disability.

PI_NAMEs: LIU, YUAN  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Acetylation;Ataxia;autosome;Bacteria;Bacterial Proteins;Base Excision Repairs;Biological Assay;biomacromolecule;Brain;Capillary Electrophoresis;career;career development;Cell Differentiation process;Chimeric Proteins;Chromatin;chromatin immunoprecipitation;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;Contracts;Dedications;demethylation;disability;Disease;DNA;DNA Repair;Drug Delivery Systems;Encapsulated;Escherichia coli;Faculty;Family;Fellowship;forging;frataxin;Friedreich Ataxia;Funding;Future;Gene Expression;Gene Targeting;gene therapy;Genes;Genome;Goals;Grant;Guide RNA;Health;Heterochromatin;Hispanic;histone demethylase;Histone H3;Histones;Human;induced pluripotent stem cell;Inherited;innovation;Introns;Lysine;major vault protein;Mediating;Mentors;Mentorship;Methylation;minority student;Minority Women;Mission;nanoparticle;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;neurodegenerative phenotype;Neurons;Neurosciences;Neurosciences Research;novel;Patients;Phenotype;Plasmids;Population;Positioning Attribute;Postdoctoral Fellow;Principal Investigator;programs;protein complex;protein expression;Proteins;public health relevance;Recombinants;recruit;repair enzyme;Research;Resources;Secure;skills;success;Supervision;System;tenure track;Testing;Training;Transgenic Mice;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Up-Regulation

PROJECT_TITLE: Frataxin Gene-Targeted GAA Repeat Contraction Through A Vault Bionanoparticle-Mediated CRISPR/dCas9 System In Friedreich's Ataxia


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The Latinx community bears a disproportionate burden of chronic kidney disease, and they are less likely to start recommended kidney replacement therapy, such as kidney transplant or home dialysis, compared to non- Latinx White individuals. Our funded parent grant allows us to conduct a patient-level randomized controlled trial of NAVIGATE-Kidney, a multi-level, community health worker intervention for Latinx with kidney disease, that will reduce kidney health disparities. The proposed supplement builds on the parent grant plan for enhancing diverse perspectives (PEDP) by increasing the research workforce through direct one to one mentorship of physician scientists focused on kidney health disparities research and through the development of a kidney disease community health worker training program.

PI_NAMEs: CERVANTES, LILIA  (contact);MYASKOVSKY, LARISSA

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: Address;Adult;Arteriovenous fistula;arteriovenous graft;Award;Caring;Catheters;Certification;Cessation of life;Chronic Kidney Failure;Clinical Trials;Communities;community building;community engaged research;community engagement;Community Health Aides;Conflict (Psychology);Data;design;Development;Dialysis procedure;Disease;Disparity;Dissemination and Implementation;Education;Ensure;experience;Face;Feedback;Funding;Gardenia;Gender;Goals;Grant;Health Disparities Research;health disparity;Hemodialysis;high risk;High School Student;Hispanic Populations;Home;Individual;Infection;infection risk;Institution;Instruction;Intervention;Intervention Studies;Kidney;Kidney Diseases;Kidney Failure;Kidney Transplantation;Language;Latino;Latinx;Latinx population;Leadership;Maintenance;Medical;Medical Students;Mentors;Mentorship;Methods;model design;mortality risk;Nephrology;parent grant;patient navigation;Patient-Focused Outcomes;Patients;person centered;Physicians;pilot test;Policies;primary endpoint;primary outcome;Publications;Randomized;Randomized, Controlled Trials;Recommendation;Renal Replacement Therapy;Research;Research Methodology;Research Personnel;Risk;Scientist;skill acquisition;Specialist;Structural Racism;Technical Expertise;Testing;Time;Training;Training Programs;undergraduate student;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;Valverde;Venous;Work;Writing

PROJECT_TITLE: NAVIGATE-Kidney: Increasing diversity in the research workforce


ORG_CITY: ARLINGTON

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

ORG_STATE: TX

PHR: Project Narrative: This application seeks funding for a UV/Vis spectrophotometer in order to add critical UV/Vis spectrophotometric data to the parental study plan. The parental study aims to research the processes underlying the redox-mediated activations of Arf and Rho GTPases and to explore the therapeutic effects of novel redox-inert nucleotide analogs that desensitize the redox response of these small GTPases. The addition of the UV/Vis spectrophotometric approach will aid the discovery of the redox-inert desensitizer drugs that may lead to a molecular and mechanistic basis for developing therapies for immune disorders and other relevant diseases associated with the uncontrolled redox functions of these small GTPases.

PI_NAMEs: HEO, JONGYUN  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: adduct;Applications Grants;Binding;Biochemical;Biochemistry;Cell Physiology;Cellular biology;Data;desensitization;Detection;Development;Disease;Family;Funding;Goals;Guanosine Triphosphate;Immune System Diseases;interdisciplinary approach;Light;Mediating;Methods;Molecular;Monitor;Monomeric GTP-Binding Proteins;multidisciplinary;Mutagenesis;novel;novel therapeutic intervention;nucleotide analog;Nucleotides;Oxidation-Reduction;Pharmaceutical Preparations;Play;Process;Property;Protein Family;protein function;Proteins;Regulation;Research;response;rho;rho GTP-Binding Proteins;Role;Spectrophotometry;Therapeutic Effect;Therapeutic Intervention;therapeutically effective;therapy development

PROJECT_TITLE: Mechanistic characterizations of redox regulations and functions of Arf and Rho families


NIH_SPENDING_CATS: Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Intestinal bacterial pathogens are a major cause of morbidity and mortality globally and a leading cause of death among children. The goals of this proposal are to understand how specific metabolites from bacteria regulate host epithelial cells to protect against intestinal bacterial infection. The outcomes of these studies will benefit human health because they will inform the design of new approaches for improving intestinal immunity to fight infection.

PI_NAMEs: ALENGHAT, THERESA  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Anti-Bacterial Agents;Bacteria;Bacterial Infections;beneficial microorganism;Calibration;Cause of Death;Child;Citrobacter rodentium;commensal bacteria;Complex;design;Development;Dietary Component;Enteral;enteric infection;enteric pathogen;enteropathogenic Escherichia coli;Epigenetic Process;epigenome;Epithelial Cells;Escherichia coli Infections;Exposure to;fighting;Goals;Health;Host Defense;Human;human model;Immune;Immune response;Immunity;improved;Infection;intestinal barrier;intestinal epithelium;Intestines;Metabolism;Microbe;microbial;microbiota;Morbidity - disease rate;mortality;mouse model;novel strategies;Organoids;Outcome Study;pathogen;pathogenic bacteria;pathogenic microbe;Pathogenicity;Pathway interactions;Public Health;Regulation;Signal Transduction;therapeutic evaluation;Tissues;Transgenic Animals

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Transplantation

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative: This project will develop novel mouse models to study hematopoietic stem cells (HSCs) and their differentiation into various blood and immune cells. Current methods have limitations in tracking individual HSCs and their progeny in their endogenous microenvironment, limiting our understanding of their behavior. We will overcome this by creating a multi-color, multi-loci mouse reporter system using cutting-edge CRISPR/Cas9-mediated knock-in technology, that will allow for live tracking of HSCs in many tissues and organ systems.

PI_NAMEs: TAMPLIN, OWEN JAMES (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Abbreviations;Address;Aging;Alleles;Animal Model;Antibodies;Behavior;Biological;Biological Assay;Biology;Blood;Body System;bone;Bone Marrow;Bone Marrow Cytometry;cell behavior;Cell Communication;Cell Count;cell type;Cells;Cellular Assay;Chromosome 1;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Color;Confocal Microscopy;CRISPR/Cas technology;Data;daughter cell;Dependovirus;Development;Differentiation Antigens;Disease;Dissociation;DNA Double Strand Break;Electroporation;Endothelial Cells;ex vivo imaging;Eye;Flow Cytometry;Funding Opportunities;Genes;graft vs host disease;Harvest;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic hierarchy;Hematopoietic Neoplasms;hematopoietic stem cell differentiation;hematopoietic stem cell expansion;hematopoietic stem cell fate;Hematopoietic stem cells;Homeostasis;Homologous Transplantation;Immune;Immune system;improved;In Vitro;in vivo;Individual;Infection;Infertility;interest;intravital imaging;intravital microscopy;Knock-in;Label;Left;leukemic stem cell;light microscopy;Link;loss of function;Malignant Neoplasms;Maps;Measures;Mediating;Methods;migration;Modeling;mouse model;Multipotent Stem Cells;Mus;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Open Reading Frames;Output;Population;preservation;Process;Production;progenitor;Proliferating;protein expression;Proteins;Proto-Oncogene Protein c-kit;Publishing;reconstitution;Regenerative Medicine;Regulation;repaired;Reporter;Research;Research Personnel;Research Proposals;response;Ribonucleoproteins;screening;SLAM protein;Sorting;Specificity;stem cell biology;stem cell differentiation;stem cell division;stem cell expansion;stem cell model;stem cell population;stem cells;Stress;System;Technology;Testing;Time;Tissues;tool;Transgenic Organisms;transplant model;Transplantation;United States National Institutes of Health;Validation;Work;zygote

PROJECT_TITLE: Multicolor mouse models to resolve hematopoietic stem and progenitor cells in vivo

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: NARRATIVE Opioid use disorder (OUD) is the third leading cause of preventable death in the United States and negatively affects the quality of life of millions of people; we propose to test the best-available activators and inhibitors of the Neuropeptide S (NPS) receptor (NPSR1) for their therapeutic potential in rat models of distinct phases of OUD. More broadly, the experiments proposed will generate the preliminary data necessary to justify a large- scale, collaborative drug-development effort aimed at developing novel small molecule ligands of the NPSR1. Ultimately it is our hope that these efforts generate new and urgently needed treatment options for OUD.

PI_NAMEs: TUNSTALL, BRENDAN  (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Abstinence;Acceleration;Affect;Agonist;Alcohol dependence;alcohol seeking behavior;Animal Model;Anniversary;antagonist;Anti-Anxiety Agents;Anxiety Disorders;anxiety-related disorders;anxious;Arousal;Behavior;Belief;Binding;Binding Sites;Brain;cocaine seeking;combat;comorbidity;Data;Dependence;Development;drug discovery;drug of abuse;drug relapse;early onset;effective therapy;Equipment;experience;experimental study;Female;Fentanyl;fentanyl seeking;fentanyl self-administration;Future;Goals;Helping to End Addiction Long-term;high risk;Human;hypnotic;improved;inhibitor;Intervention;Knowledge;Ligands;Literature;Logic;male;Measures;men's group;Modeling;Motivation;National Institute of Drug Abuse;National Institute on Alcohol Abuse and Alcoholism;Nature;negative emotional state;Neurobiology;Neuropeptide Receptor;Neuropeptides;novel;Opiate Addiction;Opioid;opioid epidemic;opioid exposure;opioid misuse;opioid overdose;opioid use;opioid use disorder;opioid withdrawal;Oral;Overdose;Peptides;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;polysubstance abuse;pre-clinical;Pre-Clinical Model;preventable death;Public Health;Quality of life;Rattus;receptor;Relapse;Reporting;Research;Research Project Grants;Research Support;Rewards;Rodent;Role;Science;sedative;Self Administration;sexual dimorphism;Signal Transduction;small molecule;Solid;Specificity;Stress;synthetic opioid;System;Testing;Therapeutic;therapeutic evaluation;tool;Treatment Efficacy;United States;United States National Institutes of Health;Validation;Withdrawal

PROJECT_TITLE: Neuropeptide S Receptor 1 as a Novel Target for Reducing Opioid Self-Administration and Opioid Relapse

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 IXR-N (A2)]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Project Narrative Synaptic zinc is a powerful neuromodulatory neurotransmitter. Since disruptions of synaptic zinc signaling lead to a range of sensory and behavioral deficits and mutations in zinc transport proteins are linked with schizophrenia and autism, we seek to uncover mechanisms by which synaptic zinc shapes neuronal processing.

PI_NAMEs: ANDERSON, CHARLES  (contact)

PROJECT_TERMS: AMPA Receptors;Auditory area;auditory processing;autism spectrum disorder;awake;Basal Ganglia;Behavioral;Biological Assay;Brain;Brain region;Calcium;Carrier Proteins;design;Glutamates;Goals;high throughput screening;Hippocampus;Human;Image;Impaired cognition;In Vitro;in vivo;insight;Knockout Mice;Lead;Link;link protein;Mediating;Mus;Mutation;N-Methyl-D-Aspartate Receptors;Nervous System Disorder;neural;Neurons;neuroregulation;Neurotransmitters;novel;optogenetics;Pathologic;Population;Preparation;presynaptic;response;Role;Schizophrenia;Sensory;Sensory impairment;Shapes;Signal Transduction;SLC30A3 gene;Slice;Structure;Synapses;Synaptic Transmission;Synaptic Vesicles;tool;transmission process;two-photon;Zinc;zinc-binding protein

PROJECT_TITLE: Synapse-specific effects of synaptically released zinc: implications for auditory processing


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

ORG_CITY: BIDDEFORD

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NEW ENGLAND

ORG_STATE: ME

PHR: Chronic pain continues to be a major health, social and economic problem throughout the world, affecting an estimated 1 in 3 individuals. Current therapies for chronic pain offer only modest efficacy and/or have serious side-effects. As a result, there is a need to focus on treating pain, on preventing the development of chronic pain, and on research and development of novel treatments (including restoration of lost function and improvement of quality of life).

PI_NAMEs: MENG, IAN D (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Acute Pain;addiction liability;Advisory Committees;Affect;alternative treatment;Applications Grants;Award;base;Behavior;Biological;Biomedical Research;Businesses;career development;Centers of Research Excellence;chronic pain;chronic pain management;Classification;Clinical;Collaborations;Communities;Consultations;Continuing Education;Contract Services;Contracts;Core Facility;COVID-19 impact;Dedications;Development;Doctor of Philosophy;Economics;Educational workshop;Engineering;Environment;Epidemic;Equipment;Extramural Activities;Faculty;Fee-for-Service Plans;Fees;Fellowship;Financial Support;Funding;Goals;Grant;Health;higher education;Histology;Human Resources;Image;Immune;improved;Income;Individual;Industry;industry partner;Institution;instrumentation;Intervention;Investments;Joints;Journals;Laboratories;Learning;Maine;Maintenance;Marketing;Medical Research;Mentorship;Neurons;Neurosciences;New England;New Hampshire;novel;Opioid;opioid epidemic;Pain;pain chronification;pain relief;Pain Research;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phase I Clinical Trials;Pilot Projects;Population;prescription opioid;prevent;Program Development;Program Research Project Grants;programs;Publications;Quality of life;recruit;Research;Research Activity;research and development;research facility;Research Institute;Research Personnel;Research Project Grants;Research Support;restoration;reuptake;Science;Scientific Advances and Accomplishments;Secure;Sensory;Series;Services;Severities;side effect;Signal Pathway;Signal Transduction;skills;Small Business Innovation Research Grant;Small Business Technology Transfer Research;social;Strategic Planning;Students;success;Sustainable Development;sustainable resource;Time;Training;Travel;Universities;voucher;Wages;Work

PROJECT_TITLE: Interdisciplinary Center of Excellence for the Study of Pain and Sensory Function


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The goal of the proposed supplement to our existing NIMH T32 predoctoral training grant (TASHI) is provide in-depth, tailored mentorship and support to a diverse cohort of existing trainees, all of whom are from groups under-represented in scientific research, to strengthen their expertise in community-engaged health equity research. The proposed activities with help strengthen and sustain TASHI’s impact, support a group of emerging health equity scholars, and offer a model for other health equity focused NIH T32 training grants.

PI_NAMEs: BOWLEG, INGRID ALISA;KERRIGAN, DEANNA L (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Address;HIV;social structure;structural determinants;Training Programs

PROJECT_TITLE: Training Program in Approaches to Address Social-Structural Factors Related to HIV Intersectionally (TASHI)


ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative This project is relevant to public health because the understanding of how conformational dynamics affect the regulation, allosteric modulation, ligand binding kinetics and drug specificity of protein kinases is expected to increase understanding of disease-relevant kinase signaling pathways. The project aims to advance this fundamental knowledge and to develop macrocyclic therapeutics.

PI_NAMEs: SEELIGER, MARKUS A (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: 10 year old;Affect;Chromatography;cost;Disease;fast protein liquid chromatography;instrument;instrumentation;Kinetics;Knowledge;Ligand Binding;Manufacturer;Molecular Conformation;Pharmaceutical Preparations;Phosphotransferases;Protein Kinase;protein purification;Public Health;Regulation;repaired;Signal Pathway;Specificity;System;Therapeutic;virtual;Work

PROJECT_TITLE: Dynamics of Ligand Binding and Protein Kinase Regulation


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Disability Research;Osteoarthritis;Pain Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: NARRATIVE Our overall goal is to identify cross-sectional and longitudinal local patterns of cartilage and bone interactions unique to patellofemoral joint osteoarthritis and determine the mediation effects of gait biomechanics and bone morphology on disease progression. We will conduct a longitudinal cohort study investigating 100 people with isolated patellofemoral joint osteoarthritis, followed for 2 years. This work is urgently needed to fully understand bone-cartilage interactions and reveal biomechanical risk factors for patellofemoral joint osteoarthritis progression.

PI_NAMEs: MAJUMDAR, SHARMILA ;SOUZA, RICHARD BRIAN (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Acceleration;Adult;Biochemistry;Biomechanics;Blood Vessels;bone;Bone remodeling;Cartilage;cartilage degradation;Collagen;Complex;Cross-Sectional Studies;Data;Degenerative polyarthritis;disability;Disease;Disease Progression;Enzymes;Etiology;Evaluation;Extracellular Matrix;feature extraction;Femur;follow-up;Functional disorder;Gait;Gait abnormality;Goals;Image;imaging biomarker;imaging study;Incidence;Individual;inhibitor;Invaded;Investigation;joint biomechanics;joint loading;Joints;Knee bone;Knee Osteoarthritis;knee pain;Longitudinal cohort study;Longitudinal Studies;Magnetic Resonance Imaging;Maps;Measures;Mechanics;Mediating;Mediation;Metabolic;Metabolism;Modality;Modeling;Morphology;Musculoskeletal;Outcome;Pain;Pathogenesis;Pattern;Peptide Hydrolases;Persons;Process;Proteoglycan;Protons;Questionnaires;radiological imaging;Relaxation;Resolution;Risk Factors;Role;Shapes;soft tissue;Source;Standardization;subchondral bone;substantia spongiosa;System;Thick;Time;Tissue imaging;tomography;treatment strategy;uptake;Variant;Work

PROJECT_TITLE: Simultaneous Imaging of Tissue Biochemistry and Metabolism associated with Biomechanics in Patella Femoral Joint Osteoarthritis

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: NARRATIVE Alcohol Use Disorder (AUD) is highly prevalent in and highly destructive for people living with major mental illness. While effective medications for AUD exist, these patients rarely are prescribed them, representing a gap in care. We propose an implementation facilitation intervention to support increased prescribing in psychiatric treatment settings, where these patients receive much of their mental health and addictions care.

PI_NAMEs: BENNETT, MELANIE E. (contact);ROCHE, DANIEL

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: addiction;Address;Adopted;Affect;alcohol abuse therapy;alcohol comorbidity;alcohol use disorder;Appointment;care coordination;Caring;Clinic;Collaborations;comorbidity;Consultations;Data;depressive symptoms;Diagnosis;Drug Prescriptions;dual diagnosis;Education;Educational Materials;Educational Status;Environment;Ethnic Origin;evidence base;Evidence based practice;Exclusion;experience;FDA approved;Feedback;formative assessment;Fostering;General Population;health disparity;Health Personnel;Hospitals;implementation facilitation;implementation strategy;improved;Individual;Interpersonal Relations;Intervention;Knowledge;Learning;Literature;Major Mental Illness;marginalization;medical specialties;Mental Health;Modification;Monitor;Mood Disorders;National Institute on Alcohol Abuse and Alcoholism;Outcome;Patient Education;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Physicians;pilot test;post implementation;Post-Traumatic Stress Disorders;Practice Guidelines;Primary Care;Problem Solving;Process;programs;Promoting Action on Research Implementation in Health Services framework;provider-level barriers;Psychiatric therapeutic procedure;Psychiatrist;Psychiatry;psychosocial;Psychotherapy;Psychotic Disorders;Qualitative Methods;Race;Recovery;Reporting;Research;response;Role;routine care;schizophrenia spectrum disorder;Screening Result;Service setting;Services;Site;social stigma;Standardization;System;Testing;Training;Treatment outcome;Work

PROJECT_TITLE: External Facilitation to Increase Prescribing of AUD Medications in the Psychiatric Setting

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: DE

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Infectious Diseases;Rare Diseases;Women's Health Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Narrative Sjögren’s syndrome (SS), a chronic inflammatory autoimmune disease that affects ~ 4 million Americans, particularly women, is characterized by hyposalivation and dacryoadenitis with lymphocytic infiltration of salivary and lacrimal glands. Our research focuses on the cell surface receptors, P2X7 and P2Y2, for extracellular ATP, the chemical form of energy in a cell that when released from injured or diseased salivary and lacrimal gland tissue causes inflammation. The overall goal of these studies is to evaluate whether antagonism of the P2X7R and/or P2Y2R can protect the salivary and lacrimal glands from tissue damage in SS patients by investigating these novel signaling pathways in mouse models of SS.

PI_NAMEs: WEISMAN, GARY ANDREW (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Acinar Cell;Affect;Agonist;American;antagonist;Apoptosis;Archives;Artificial Saliva;Artificial Tears;Autoantibodies;Autoimmune Diseases;autoimmune exocrinopathy;Autoimmunity;Autologous;Bacterial Infections;Biopsy;Cadaver;cancer surgery;CD28 gene;cell injury;cell motility;Cell Separation;Cell surface;Cell Surface Receptors;Cells;Chemicals;Chronic;Clinical Trials;Coupled;Crohn's disease;cytokine;Dental caries;Deterioration;Development;Digestive System Disorders;Disease;Drainage procedure;Drops;Dry Eye Syndromes;Epithelial Cells;Epithelium;Exhibits;extracellular;eye dryness;Female;Fibrosis;Film;Fluids and Secretions;Functional disorder;Goals;GTP-Binding Proteins;Human;Hydration status;IL18 gene;Immune;Immune response;Immunomodulators;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;injured;innovation;Interferon Type II;Interleukin-1 beta;Interleukins;Ion Channel Gating;Knock-out;Lacrimal gland structure;Lupus;Lymphocyte;Lymphocytic Infiltrate;Lymphoma;Mediating;Minor;Minor salivary gland structure;mouse model;Mus;Muscarinic Acetylcholine Receptor;novel;Nucleotides;ocular pain;Ocular Pathology;ocular surface;Oral Pathology;P2Y2 receptor;Pathogenesis;Patients;Periodontitis;Phase;Play;preservation;prevent;Process;Production;Productivity;Proliferating;Quality of life;receptor;Receptor Activation;receptor expression;Receptor Signaling;Receptor Up-Regulation;receptor upregulation;Research;Residual state;Rheumatoid Arthritis;Role;Saliva;saliva secretion;Salivary Gland Diseases;Salivary Glands;Secondary to;Serum;Sialadenitis;Signal Pathway;Site;Sjogren's Syndrome;spatiotemporal;Submandibular gland;symptom management;Systemic Lupus Erythematosus;Testing;Throat Cancer;tissue degeneration;Tissues;Transgenic Organisms;Vision;Woman;Work;Xerophthalmia;Xerostomia;yeast infection

PROJECT_TITLE: Targeting P2 Receptors to Restore Salivary and Lacrimal Gland Function in Sjogren's Syndrome

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ORG_CITY: LAS CRUCES

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

ORG_STATE: NM

PHR: Project Narrative The New Mexico IDeA Networks of Biomedical Research Excellence (NM-INBRE) is strongly committed to (under)graduate research and education and strives to engage demographics underrepresented in STEM fields while expanding research/career opportunities for the students and increasing the number of competitive investigators in the scientific workforce. By adapting our existing NM-INBRE pangenomics workshop into an open-source Cloud Lab Module that can be taken independently or integrated into other curricula, we are greatly increasing the number of students and researchers that can utilize these modern pangenomics techniques in biomedical research. The short and long term benefits of this are many, including allowing current researchers to utilize these skills immediately in their biomedical research and arming students with these advanced skills prior to entering the (bio)medical workforce.

PI_NAMEs: LUSETTI, SHELLEY  (contact)

PROJECT_TERMS: Address;arm;Biomedical Research;career;Communities;Computer software;cost effective;cost effectiveness;Data;demographics;Disease;Drug Targeting;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Environment;Equity;Evolution;Genetic;Genome;Goals;graduate student;improved;interest;Knowledge;laboratory module;Learning;Length;Malignant Neoplasms;Medical;Modernization;Mutation;National Institute of General Medical Sciences;New Mexico;open source;pan-genome;preservation;Privatization;Proliferating;reference genome;Research;Research Personnel;skills;STEM field;Students;Techniques;Technology;Tissues;tool;Vaccines;Variant;Work

PROJECT_TITLE: New Mexico IDeA Networks of Biomedical Research Excellence (INBRE)


ORG_CITY: FAYETTEVILLE

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: PROJECT NARRATIVE We propose to install an Agilent LC/Q-TOF mass spectrometer that is capable of sensitive measurements of metabolites, allowing researchers to identify flux through different metabolic pathways in a variety of biomedical experiments. The results from the LC/Q-TOF system can seamlessly integrate with the respirometry data acquired through existing AIMRC Bioenergetics core equipment to provide a comprehensive assessment of cell metabolism.

PI_NAMEs: QUINN, KYLE PATRICK (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Animals;Arkansas;Biochemical Pathway;Bioenergetics;Biomedical Research;Cells;Cellular Metabolic Process;Centers of Research Excellence;Complement;cytate;Data;Data Science;Development;Disease;Equipment;experimental study;Faculty;functional genomics;Future;Genus Hippocampus;Image;instrument;Interdisciplinary Study;mass spectrometer;Measurement;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Molecular;Phase;Proteomics;recruit;repaired;Research;Research Personnel;Research Project Grants;Resources;Role;Spirometry;System;Tissues;Universities

PROJECT_TITLE: Arkansas Integrative Metabolic Research Center


NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative Rapid molecular oscillators are important for generating segmental pattern during development, for promoting heterogeneous responses in neural stem cells, and for biasing embryonic stem cells toward different cell fates. For the parent project, we are discovering new oscillatory genes, uncovering their biological functions, and dissecting the regulatory mechanisms that govern their oscillatory expression. We propose that our discoveries will impact studies in fields as diverse as stem cell biology, tissue engineering, and even cancer cell biology..

PI_NAMEs: AMACHER, SHARON L (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Arabidopsis;Biological Pacemakers;Biological Process;biological systems;cancer cell;Cells;Cellular biology;cytokine;Cytoplasm;Development;Embryo;embryonic stem cell;Environment;Equipment;experimental study;Feedback;Fibroblast Growth Factor;Gene Family;Genes;Genetic;Genetic Transcription;Human;In Vitro;Lateral;Mesoderm;Metabolic;Molecular;Molting;Mus;mutant;nerve stem cell;NF-kappa B;notch protein;Nuclear;parent grant;parent project;Pathway interactions;Pattern;Periodicals;Periodicity;Play;posttranscriptional;Process;Proteins;Radiation;Regulation;response;Role;Segmentation Clock Pathway;Signal Transduction;Somites;somitogenesis;Starvation;stem cell biology;Stem cell pluripotency;stem cells;System;Tissue Engineering;TP53 gene;Transcript;transcription factor;Transcription Repressor;Vertebrates;Work;Yeasts;Zebrafish

PROJECT_TITLE: Developmental regulation of oscillatory expression

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: EL PASO

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

PHR: Project Narrative Alzheimer’s disease and other dementias are chronic and progressive diseases without cure, imposing a huge health economic burden in our society. The proposed research is directed at advancing our knowledge of dementia etiology, which would facilitate the development of new prevention and therapeutic strategies.

PI_NAMEs: HAN, KYUNG-AN  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: age related;age related neurodegeneration;Alzheimer's Disease;Animal Model;biological research;caucasian American;Chronic Disease;Communities;Consumption;cost;Dementia;Development;Dissection;Drosophila genus;Drosophila melanogaster;Economic Burden;endophenotype;Etiology;executive function;gene discovery;Genes;Genetic;genetic risk factor;Genetic Screening;genomic locus;Goals;health economics;Hispanic Populations;innovation;insight;Knowledge;Memory;Memory Loss;model organism;Neurosciences Research;non-genetic;Prevalence;Prevention;Progressive Disease;Research;Research Training;Risk Factors;Societies;Students;Symptoms;Testing;Therapeutic;Time;tool;Training and Education

PROJECT_TITLE: Genetic dissection of dementia


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Sudden Unexpected Death in Epilepsy (SUDEP) accounts for between 8 and 17% of all epilepsy-related deaths and, although our understanding of SUDEP is rudimentary, there is increasing evidence that respiratory arrest after a convulsive seizure is the primary cause in many cases. In support of this, we have found that seizure-induced apnea that occurs during the tonic phase and failure of postictal breathing recovery produce SUDEP in mouse models. Using novel mouse models of SUDEP, we propose to use chemogenetic, optogenetic, and electrophysiological techniques to elucidate the underlying neural circuitry that is recruited to cause seizure-induced apnea and SUDEP.

PI_NAMEs: WENKER, IAN CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: afferent nerve;Apnea;Brain Stem;Breathing;Bypass;Cardiac;Cause of Death;Cell Nucleus;Cessation of life;Chromosome Mapping;Clonic Seizure;Data;Development;Electrophysiology (science);Elements;Epilepsy;Failure;FOXP2 gene;Generations;Genetic;Heart Arrest;hindbrain;in vivo;Injections;Interruption;Midbrain structure;Modeling;Motor Seizures;mouse model;Mus;Muscle;mutant;Mutant Strains Mice;Mutation;Nerve Fibers;neural circuit;neuronal circuitry;neuronal excitability;Neurons;Nodal;novel;optogenetics;parabrachial nucleus;patch clamp;Patients;Pattern;Phase;Pontine structure;prevent;Prosencephalon;Recovery;recruit;Refractory;respiratory;SCN8A gene;Seizures;selective expression;Structure;Sudden Death;sudden unexpected death in epilepsy;Techniques;Testing;Tonic Seizures;Vagus nerve structure;ventilation

PROJECT_TITLE: The neural circuitry of seizure-induced apnea and SUDEP


NIH_SPENDING_CATS: Chronic Pain;Congenital Structural Anomalies;Genetics;Neurosciences;Pain Research;Pediatric;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Classic Ehlers Danlos Syndrome (cEDS) is characterized by skin hyperextensibility and fragility, abnormal wound healing, and joint hypermobility, accompanied by chronic widespread pain, refractory to analgesics. The proposed experiments focus on skin and interactions between dermal fibroblasts and neurons in molecularly elucidated cEDS patients. This is an entirely new direction in the field that will advance our knowledge of mechanisms underlying pain in cEDS, and generate important new information into mechanisms of more prevalent painful conditions where neuron-fibroblast interactions play a role in the production of abnormal skin innervation and pain.

PI_NAMEs: MALFAIT, ANNE-MARIE  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Age;Analgesics;Anatomy;axon guidance;Belgium;Calcium;Cell Proliferation;cell type;Cells;Characteristics;Chicago;chronic widespread pain;Coculture Techniques;cohort;Collaborations;Collagen Type V;Communication;comparison control;Defect;density;Dermal;Dermis;Diagnostic;differential expression;Ehlers-Danlos Syndrome;Epidermis;experimental study;Extracellular Matrix;Fibroblasts;Gene Expression Profile;Genes;Growth;Human;Hypersensitivity;Image;Immune;Immunohistochemistry;Induced pluripotent stem cell derived human neuron;Joint Laxity;keratinocyte;Knowledge;mechanical allodynia;mechanical stimulus;Mechanics;Medical center;Medical Genetics;Microfluidics;migration;Modeling;Molecular;Mus;Musculoskeletal;Musculoskeletal Pain;mutant;Mutation;Nerve;Nerve compression syndrome;Nerve Fibers;nerve supply;Neuroglia;neuronal excitability;neuronal growth;Neurons;Nociception;Nociceptors;non-opioid analgesic;novel;Outcome;Pain;Pain management;Pain Threshold;Patient Self-Report;Patients;Pattern;Peripheral;Phenotype;Positioning Attribute;Process;Production;Proteins;Refractory;Reporter;Research;Resources;Role;Sensory;Skin;Skin Abnormalities;skin biopsy;Skin Tissue;somatosensory;Source;Syndrome;System;Techniques;Testing;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Translating;TRPV1 gene;Universities;Visualization;wound healing

PROJECT_TITLE: The role of Nerve-fibroblast communication in EDS pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Obesity;Osteoporosis

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

PHR: Narrative This application requests Phase II support for a successful COBRE in Mesenchymal and Neural Regulation of Metabolic Networks. Three new diverse projects study thermogenic adipocytes, gut-bone interactions, and impact of night shift work on diabetes risk in pregnancy, and they will contribute to our knowledge about how to better treat chronic metabolic diseases. Core facilities provide support for Physiology, Histopathology and Microscopy, and Proteomics and Lipidomics.

PI_NAMEs: LIAW, LUCY  (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Achievement;acute care;Adipocytes;Adipose tissue;Advisory Committees;Area;arm;Award;bariatric surgery;base;Basic Science;Biochemical Pathway;Biology;Biomedical Research;bone;bone loss;Bone Marrow;Cardiovascular system;career development;Career Mobility;Caregivers;Caring;Centers of Research Excellence;Chronic;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;Complement;Core Facility;Country;Data Analyses;Data Analytics;Development;Diabetes Mellitus;diabetes risk;Disease;diversity and inclusion;Doctor of Philosophy;doctoral student;Education;Equipment;equity, diversity, and inclusion;Experimental Designs;Faculty;Faculty Recruitment;Feedback;Fellowship;Fostering;Foundations;Funding;Goals;Grant;Growth;Health;Healthcare;Histopathology;Hospitals;improved;Infrastructure;Institution;instrumentation;interest;Investments;Knowledge;Lead;Leadership;lipidomics;Maine;Medical center;member;Mentors;Mentorship;Mesenchymal;Metabolic;Metabolic Diseases;Metabolism;Microscopy;Mission;model development;Modeling;Morbidity - disease rate;mortality;neural;neuroregulation;New England;Obesity;Osteoporosis;Pain;Patient Care;Performance;pharmacologic;Phase;Physiology;Pilot Projects;Policies;population health;Population Research;Predisposition;Pregnancy;Pregnant Women;Principal Investigator;Productivity;Professional Education;professor;Program Evaluation;programs;Proteomics;Public Health;recruit;Request for Applications;Research;Research Institute;Research Personnel;Research Project Grants;Resource Sharing;Resources;responsible research conduct;rural disparities;Scientist;Sensory;Services;shift work;Signal Transduction;skeletal;Smooth Muscle;student mentoring;Student recruitment;success;synergism;Talents;Technology;Time;Tissues;Training;Training and Education;Translational Research;United States National Institutes of Health;Universities;Update;Work

PROJECT_TITLE: Phase II COBRE in Mesenchymal and Neural Regulation of Metabolic Networks - Equipment


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: NEW YORK

ORG_DEPT: CHEMISTRY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative Errors in cell division have been linked to developmental defects and disease in humans. We take inter- disciplinary approaches to decipher the molecular mechanisms required for accurate cell division. Our findings have the potential to facilitate the development of new therapeutic strategies based on targeting cell division and the cytoskeleton.

PI_NAMEs: KAPOOR, TARUN M. (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;ATP phosphohydrolase;Biochemical;Cell division;Cell Line;Cell Physiology;Cells;Cellular biology;Centrosome;Chemicals;Chromosomes;Complex;Cytoskeleton;Defect;Development;Disease;Dose;Goals;Hour;Human;Image Analysis;inhibitor;insight;interdisciplinary approach;Knowledge;Length;Light;Link;Malignant Neoplasms;Measures;meter;Microscopy;Microtubules;Mitosis;Molecular;Motor;nanoscale;Neurons;novel therapeutic intervention;novel therapeutics;Nuclear;Output;Permeability;Phenotype;Process;protein function;protein protein interaction;Proteins;Proteomics;quantitative imaging;Recombinants;Research;Resistance;self assembly;structural biology;Structure;Tubulin

PROJECT_TITLE: Chemical Biology of Cell Division


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: EAST LANSING

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PI_NAMEs: NAGHIBOLHOSSEINI, MARYAM  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: accurate diagnosis;Acoustics;Address;Administrative Supplement;Affect;Aftercare;Anatomy;career;career development;Caring;Characteristics;Clinic;Communication;Complex;Computer Models;computerized data processing;cost;Data;Dedications;Diagnosis;Disease;Edema;Educational workshop;emotional distress;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Funding;Future;Goals;Grant;Growth and Development function;Guidelines;Histologic;Image;Image Analysis;Impairment;ineffective therapies;Intervention;Journals;Judgment;Knowledge;Laryngitis;Larynx;Lesion;Literature;Measurement;Measures;Medical;Mentors;Mentorship;Modeling;National Institute on Deafness and Other Communication Disorders;Operative Surgical Procedures;Outcome;Paper;Parameter Estimation;parent project;Parents;Patients;Performance;Physiological;Polyps;Procedures;Production;professor;programs;Publications;Publishing;Quality of life;Research;Role;Science;signal processing;Social Interaction;Speed;Structural Models;Students;symposium;tool;Training;Uncertainty;unnecessary treatment;Validation;verification and validation;vocal cord;Voice;Voice Disorders;voice therapy;Work

PROJECT_TITLE: DEIA Mentorship Supplement to Early Career Research (ECR) R21 Award

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: An automated flash chromatography system is essential to our research in the development of new drug molecules to target PRMTs and other epigenetic proteins. It will also assist our educational effort to train next generation undergraduate and graduate students in learning modern organic chemistry techniques.

PI_NAMEs: ZHENG, Y. GEORGE  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Administrative Supplement;chemical reaction;Chemicals;Chromatography;Development;Education;Enzyme Inhibitor Drugs;Enzymes;Epigenetic Process;Equipment;equipment acquisition;graduate student;Learning;Liquid substance;Modernization;next generation;novel therapeutics;Optical reporter;Organic Chemistry;parent project;Peptides;Protein Inhibition;Protein Methylation;Proteins;Research;small molecule;System;Techniques;Training;undergraduate student

PROJECT_TITLE: Mechanism and Inhibition of Protein Methylation