ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Coronary artery disease disrupts the vascular network that supplies the heart with oxygen and nutrients, and is a major risk factor for heart attack, the leading cause of death worldwide. Here we will define how cells that line the fetal heart, called epicardial cells, help guide coronary blood vessel cells into a fully functional vascular network. This study may improve our understanding of the developmental causes of coronary artery disease, and lead to new therapeutic approaches to stimulate blood vessel formation after a heart attack.

PI_NAMEs: SMALL, ERIC M (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Acceleration;Address;ANGPTL2 gene;Bioinformatics;Blood;blood vessel development;Blood Vessels;Cardiac Myocytes;Cardiovascular system;Cause of Death;cell behavior;Cell Line;Cell Maturation;Cell Separation;Cell Surface Receptors;Cells;Cellular biology;chemokine;Coronary;Coronary Arteriosclerosis;Coronary Vessels;Cues;Data;Defect;Development;Embryo;Endothelial Cells;endothelial stem cell;Epicardium;epithelial to mesenchymal transition;experimental study;fetal;Fetal Heart;Fibroblasts;Fluorescent in Situ Hybridization;Future;Gene Expression;Gene Expression Profiling;Gene Modified;Genes;Genetic;Genetic Transcription;Heart;Image;improved;In Vitro;in vivo;insight;interest;Ischemia;Ligands;Link;Location;Mesenchymal;Mesothelial Cell;Mesothelium;Metabolic;Molecular;Molecular Biology;Morphology;multiphoton imaging;Mus;Myocardial Infarction;Myocardial Ischemia;myocardin;Myocardium;novel;novel therapeutic intervention;Nutrient;Oxygen;Pattern;Play;Population;progenitor;programs;Proliferating;Publishing;Regulation;repaired;Reporting;revascularization;Risk Factors;Role;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;stem cells;Stretching;Surface;Therapeutic;Tissues;transcription factor;Transcriptional Regulation;transcriptomics;Vascular Endothelial Cell;Venous;wasting

PROJECT_TITLE: Mechanisms of epicardium-directed coronary vessel patterning

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: Los Angeles

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: The objective of this HORNET Center for Autonomic Nerve Recording and Stimulation Systems (CARSS) is to develop an open-architecture and open-source implantable system for autonomic nerve stimulation and recording to support clinical research for bioelectronic medicine applications. This CARSS system will consist of an (1) external charger and controller, (2) implantable pulse generator, and (3) an interoperable assortment of implantable leads for stimulation and sensing. A central goal of the effort is to enable access to the developed technology in a manner that will dramatically reduce the technical, regulatory, and financial barriers to entry into bioelectronic medicine research and thereby accelerate the development and translation of novel bioelectronic medical therapies.

PI_NAMEs: HITTI, RAJA EDWARD;MENG, ELLIS  (contact);PIKOV, VICTOR

PROGRAM_OFFICER_NAME: HUDAK, ERIC MICHAEL

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-M(50)R]


NIH_SPENDING_CATS: Biotechnology;Neurosciences

PHR: Not applicable per solicitation. Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRAsystems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components.

PI_NAMEs: MENG, ELLIS  (contact)

PROJECT_TERMS: Academia;Administrator;Advisory Committees;Ally;Area;autonomic nerve;California;Clinical;Communication;Communities;conflict resolution;Decision Making;Dedications;Ecosystem;Ensure;experience;Feedback;Goals;Individual;Industry;Institution;Leadership;meetings;open source;operation;Persons;Postdoctoral Fellow;Principal Investigator;Process;programs;Reporting;Research Personnel;Rotation;Schedule;Structure;Suggestion;System;system architecture;Technology;timeline;United States National Institutes of Health;Universities;virtual;Vision

PROJECT_TITLE: HORNET  Center for Autonomic Nerve Recording and Stimulation Systems (CARSS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-M]


PI_NAMEs: HITTI, RAJA EDWARD (contact)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PI_NAMEs: SELOVE, REBECCA  (contact)

PROJECT_TERMS: Academia;Acceleration;Address;Affect;anti-cancer research;Applications Grants;Area;biobank;Bioinformatics Shared Resource;Biometry;Black race;Breast Cancer Risk Factor;Cancer Burden;cancer care;Cancer Center;cancer health disparity;Cancer health equity;cancer prevention;cancer risk;Censuses;Clinical;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community advisory board;community building;community collaboration;community engaged research;community engagement;community organizations;Community Outreach;community partners;community research;County;design;Development;Dissemination and Implementation;dissemination science;Education and Outreach;education research;Educational Materials;Ensure;Equity;ethnic minority;Evaluation;evidence base;Faculty;Feedback;Fostering;Foundations;Funding;Goals;Grant;health equity;Health equity research;health inequalities;Healthcare;implementation science;innovation;Institution;interest;Knowledge;Learning;Learning Module;Maintenance;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;meetings;member;men;Mentorship;Methodology;metropolitan;Minority Participation;mobile application;mortality disparity;Multicultural Education;new technology;online resource;outreach;Outreach Research;Ownership;Participant;Pathology;Patients;Pilot Projects;Policies;Population;Population Research;Prevention;Process;programs;Public Health Education;racial minority;Research;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;Risk Assessment;Rural Community;Scanning;social media;Source;Students;Support Groups;survivorship;Technology;Tennessee;Testing;Training Activity;training opportunity;underserved community;Universities;web-based tool;Work

PROJECT_TITLE: Cancer Outreach Core


PI_NAMEs: PIKOV, VICTOR  (contact)


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Digestive Diseases;Inflammatory Bowel Disease;Neurosciences;Urologic Diseases

PROJECT_TERMS: Abdomen;Accelerometer;Action Potentials;Address;Algorithms;Ally;Architecture;Autoimmune Diseases;autonomic nerve;bioelectronics;Bladder;Bluetooth;Cervical;Chronic;Clinical;Clinical Research;Colon;Colon Carcinoma;Colorectal;Communication;Constipation;Crohn's disease;Darkness;Dedications;Development;Diameter;Disease;Dyspepsia;electric impedance;Electrocardiogram;Electrodes;Electromyography;Epilepsy;Face;FDA approved;Fecal Incontinence;flexibility;Gastrointestinal Motility;Gastroparesis;Heart;Ileus;Implant;Individual;Inflammatory Bowel Diseases;interest;Lead;Light Exercise;Lower urinary tract;Lung;mathematical ability;Medicine;Modality;Monitor;Morphologic artifacts;Motility;motility disorder;Motion;Movement;Muscle;Nausea;Nerve;nerve supply;neuroregulation;Obesity;obesity treatment;open source;operation;Organ;Overactive Bladder;Pelvis;Physiologic pulse;polydimethylsiloxane;Postoperative Period;Research Personnel;Rheumatoid Arthritis;Sacral nerve;signal processing;Signal Transduction;Stomach;Stroke;Substance Use Disorder;System;Technology;Temperature;Testing;treatment-resistant depression;Ulcerative Colitis;vagus nerve stimulation;wearable device;Withdrawal


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Under normal conditions, epithelial cells reside in close association with immune cells in the intestine and a reciprocal dialogue among these components maintains intestinal homeostasis. Disruption of this homeostatic state can lead to chronic intestinal inflammation and increased risk for colorectal cancer. Our studies aim to arrive at a mechanistic understanding of how A20, also known as TNFAIP3, preserves normal intestinal differentiation and protects against colitis associated cancer.

PI_NAMEs: MA, AVERIL I (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Adoptive Cell Transfers;Adult;Bar Codes;Binding;Biochemical;Cell Differentiation process;Cell Physiology;cell transformation;Cells;Chronic;colitis associated cancer;colon cancer prevention;Colon Carcinoma;Colonic Polyps;colorectal cancer risk;cytokine;Data;Enterocolitis;Enzymes;Epithelial Cells;Epithelium;Genetic Epistasis;gut inflammation;Homeostasis;Human;IL17 gene;Immune;in vivo;Inflammation;Inflammation Mediators;intercellular communication;interleukin-22;Interleukins;Intestinal Cancer;intestinal epithelium;intestinal homeostasis;Intestinal Neoplasms;Intestines;Knock-in Mouse;Length;Life;Lymphocyte;Malignant - descriptor;Malignant Neoplasms;Mediating;Molecular;mouse model;Mus;novel;paracrine;Population;Predisposition;preservation;Process;Proliferating;Proteomics;Radiation Chimera;restraint;Risk;Role;single-cell RNA sequencing;Small Intestinal Polyp;T-Lymphocyte;Testing;Tissue Preservation;Tissues;transcriptomics;Ubiquitin;Ubiquitination

PROJECT_TITLE: Ubiquitination, Intestinal Homeostasis and Cancer

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


PROJECT_TERMS: 3-Dimensional;Address;Adopted;Ally;Architecture;autonomic nerve;Autonomic nervous system disorders;Biocontrols;bioelectronics;Clinical;cost;Custom;design;Diameter;Elasticity;Electrodes;Equilibrium;fabrication;Film;flexibility;Foreign Bodies;Health;Hypertension;Immune response;Implant;Individual;Inflammatory Bowel Diseases;instrument;interest;Lead;manufacture;manufacturing technology;Measures;Medical;Medicine;Memory;Metals;Methods;Microfabrication;miniaturize;minimally invasive;Molds;Nerve;Nerve Fibers;neural;Non-Insulin-Dependent Diabetes Mellitus;novel;open source;Operative Surgical Procedures;parylene;parylene C;Perineuriums;Peripheral;Peripheral Nerves;Peripheral Nervous System;polydimethylsiloxane;Polymers;preservation;Process;Recording of previous events;Research;Rheumatoid Arthritis;Scheme;Shapes;Site;Structure;Surgical sutures;System;Testing;Thick;Thinness;tool;Welding;wound


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Childhood Injury;Hematology;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Unintentional Childhood Injury

ORG_CITY: Chicago

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: These studies will support the use of cholestyramine, an FDA approved bile sequestrant for treatment of long acting anti-coagulant rodenticide poisoning.

PI_NAMEs: FEINSTEIN, DOUGLAS L. (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Acceleration;Accidents;Acute;Adult;Anticoagulants;Appearance;Bile fluid;Blood Coagulation Factor;Cephalic;Cessation of life;Child;Cholestyramine;Circulation;Coagulation Process;Cognitive deficits;cost;Data;Development;dosage;Dose;Emulsions;Enterohepatic Circulation;Exposure to;Extravasation;Fat emulsion;FDA approved;Female;fetal anticoagulant syndrome;Funding;Goals;Hemorrhage;Homicide;Hospitalization;Human;Hydrophobicity;hypercholesterolemia;Inhalation;Injury;Laboratories;Lethal Dose 50;Liver;male;Midwestern United States;Military Personnel;Modeling;mortality;Mus;neonate;Nervous System Trauma;neuroinflammation;neuropathology;Oryctolagus cuniculus;Patients;Persons;Pharmaceutical Preparations;Plasma;Poison;Poisoning;Population;pre-Investigational New Drug meeting;pregnant;prenatal;prenatal exposure;prevent;Pruritus;pup;rapid technique;Rattus;renal damage;research clinical testing;Resistance development;Risk;Rodent;Rodenticides;Soybeans;Suicide;Symptoms;synthetic cannabinoid;Testing;Toxic Actions;Toxic effect;United States National Institutes of Health;Vitamin K 1;Warfarin;young woman

PROJECT_TITLE: Optimization of Bile Sequestrants to Treat Superwarfarin Poisoning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P(50)]


PI_NAMEs: MOUSAVI, MARAL  (contact)


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: GISHE, JEMAL  (contact)

PROJECT_TERMS: Address;anti-cancer research;Area;base;behavioral health;Behavioral Sciences;Biometry;Breast;Breast Cancer Risk Factor;cancer care;Cancer Center;Cancer Control;cancer diagnosis;cancer health disparity;cancer subtypes;cancer therapy;care delivery;Clinical;clinical infrastructure;Clinical Research;clinical training;Clinical Trials;cohort;Collaborations;Collection;community advisory board;Community Developments;community engaged research;community engagement;comorbidity;Conduct Clinical Trials;Continuity of Patient Care;control trial;Coupled;Data;Death Rate;design;Disease;Disparity;doctoral student;Early Diagnosis;education research;Educational Materials;Eligibility Determination;Enrollment;Epidemiology;Equity;ethnic minority;Etiology;Evaluation;Exclusion;Exclusion Criteria;Experimental Designs;Future;General Hospitals;Goals;Health;Healthcare;improved;Incidence;inclusion criteria;Information Dissemination;Infrastructure;Institution;Intervention;Intervention Trial;Investigator-Initiated Research;Learning;Link;Logic;Longitudinal cohort;Lung;lung cancer screening;Malignant Breast Neoplasm;Malignant Neoplasms;medical schools;Mentorship;Methods;metropolitan;Minority Access;Mission;Modeling;neoplasm registry;Observational Study;Oncology;Outcome;outreach;Palliative Care;Participant;Pathology;patient population;Patient Recruitments;Patient-Focused Outcomes;Patients;population based;Population Research;Population Sciences;pre-doctoral;Prevention;prospective;Public Hospitals;racial minority;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;research study;Research Support;Resource Sharing;Resources;Risk;Risk Assessment;Risk Factors;safety net;Science;Screening for cancer;Self Management;success;Supportive care;survivorship;Tennessee;Therapeutic Clinical Trial;Time;tobacco control;Training;trial design;Trust;Underserved Population;Universities;Woman;Work

PROJECT_TITLE: Core 1: PRACTICE Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD);Neurosciences

PROJECT_TERMS: Address;Administrator;Advisory Committees;Algorithms;artificial neural network;autonomic nerve;bioelectronics;career;Collaborations;collaborative approach;Communication;Communities;Computer software;computerized data processing;Data;Development;Documentation;Ensure;Event;Galaxy;Gender;Goals;Hour;Implant;implanted sensor;Individual;Industry;Institution;interest;interoperability;Lead;Leadership;Licensing;LinkedIn;Medicine;meetings;member;Network-based;Newsletter;online repository;open source;Patients;Physiologic pulse;Postdoctoral Fellow;programs;Reporting;Research Personnel;Resources;Running;signal processing;Site;social media;Software Engineering;Specific qualifier value;symposium;System;Systems Integration;Technology;technology platform;Testing;Training;Training Activity;United States National Institutes of Health;Update;user-friendly;Vision;wearable data;web site;wiki;Work


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative The proposed studies will contribute to public health by increasing our knowledge of the functional alterations that lead to the cognitive and behavioral deficits associated with fetal alcohol spectrum disorders, which is among the most common neurodevelopmental disease in the United States. These studies will determine the consequences of alcohol exposure during the rodent equivalent of the last trimester of human pregnancy on the brain system that integrates and redistributes memories and will provide new avenues for the development of more effective treatments for individuals with fetal alcohol spectrum disorder. The proposed studies are within the scope of Goal 1 of the NIAAA’s strategic plan to “Identify Mechanisms of Alcohol Action, Alcohol- Related Pathology, and Recovery”.

PI_NAMEs: VALENZUELA, CARLOS FERNANDO (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Action Potentials;Adolescent;Affect;alcohol consequences;alcohol effect;alcohol exposure;Alcohols;Animals;Anterior;Anterior Nuclear Group;Behavior;Behavioral;Biological;Brain;Brain region;Cells;cingulate cortex;Cognitive;Cognitive deficits;cognitive function;Data;density;Development;distributed memory;effective therapy;Electrodes;Electrophysiology (science);Emotional;Equilibrium;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Frequencies;Functional disorder;Generations;Glutamates;Goals;Head;Health;Hippocampal Formation;hippocampal pyramidal neuron;Hippocampus;Human;In Vitro;in vivo;Individual;innovation;Interneurons;Intervention;Knowledge;Label;Learning;Life;Memory;memory consolidation;Memory impairment;memory retrieval;Mus;National Institute on Alcohol Abuse and Alcoholism;neurobiological mechanism;Neurodevelopmental Disorder;neuron apoptosis;neuronal circuitry;Neurons;nonhuman primate;novel;optogenetics;Pathology;Pathway interactions;Play;postnatal;preclinical study;Pregnancy;prevent;Property;Public Health;Recovery;Research;Rodent;Role;sex;showing emotion;signal processing;Silicones;Slice;spatial memory;Strategic Planning;Structure;Synapses;Synaptic Transmission;System;Techniques;Testing;Thalamic Nuclei;Thalamic structure;Third Pregnancy Trimester;Time;transmission process;United States;way finding

PROJECT_TITLE: Alcohol and Developing Neuronal Circuits

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: The overarching theme for this project is that alcohol alters the bacteria in the gut and metabolites that the gut bacteria make among people who are infected with HIV infection and are heavy drinkers. We are examining whether this change in the bacteria and the metabolites can be reduced by taking a probiotic supplement. We are also examining whether metabolites are associated with future cardiovascular disease events (like a heart attack) or death.

PI_NAMEs: BARVE, SHIRISH S;FREIBERG, MATTHEW S (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Academic Medical Centers;Acids;Advisory Committees;Aging;Alcohol consumption;alcohol intervention;alcohol research;Alcoholic beverage heavy drinker;Alcohols;Amines;Area;Attenuated;Bacteria;Bile Acids;Biological Markers;Biological Specimen Banks;Biometry;Blood;Butyrates;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;CD4 Lymphocyte Count;Cells;Cessation of life;Cholic Acids;Choline;Clinical Trials Data Monitoring Committees;cohort;Cohort Studies;Data;data exchange;data repository;Deoxycholic Acid;Disease Progression;dysbiosis;Echocardiography;Event;Family;Fibrin fragment D;Firmicutes Bacteroidetes ratio;follow-up;Funding;Future;Goals;Grant;gut bacteria;gut dysbiosis;gut microbiome;Heart;Heart Diseases;Heavy Drinking;high risk;HIV;HIV Infections;improved;indexing;Inflammation;Inflammatory;interest;Interleukin-6;Intestinal permeability;Justice;Lead;Lipids;lipopolysaccharide-binding protein;Lung;Measures;Medical;meetings;Mentored Clinical Scientist Development Program;Mentorship;Metabolic Pathway;metabolomics;Metagenomics;microbial;microbiome;Monitor;mortality risk;mouse model;Myocardial Infarction;Oxides;Persons;Placebos;Plasma;Policies;Preparation;primary outcome;probiotic supplementation;Probiotics;Procedures;program dissemination;Program Research Project Grants;programs;Progress Reports;Publications;recruit;Regulatory T-Lymphocyte;Research;Research Personnel;Research Project Grants;Resources;Risk;Risk Factors;Role;Russia;Sampling;Serum;Services;Site;Sleep;Specimen;synergism;Training;Training Programs;trimethyloxamine;United States National Institutes of Health;Universities;Validation;Veterans;Volatile Fatty Acids;Work

PROJECT_TITLE: Microbiome, Metabolites, and Alcohol in HIV to Reduce CVD (META HIV CVD)


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Cardiovascular;Complementary and Integrative Health;HIV/AIDS;Heart Disease;Infectious Diseases;Microbiome;Nutrition;Prevention;Substance Misuse

PI_NAMEs: FREIBERG, MATTHEW S (contact)

PROJECT_TERMS: Address;Advisory Committees;Aging;Alcohol consumption;alcohol research;Alcoholic beverage heavy drinker;Alcohols;Amines;Area;Bile Acids;biobank;Biological Markers;Biological Specimen Banks;Biometry;Blood;Boston;Budgets;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;cardiovascular risk factor;Cause of Death;Cessation of life;Clinical Trials Data Monitoring Committees;cohort;Cohort Studies;Collaborations;Data;data repository;Disease;disorder risk;dysbiosis;Education;epidemiology study;Event;experience;follow-up;Fostering;Funding;Future;gastrointestinal;Goals;Grant;gut dysbiosis;gut microbiome;Heart;high risk;HIV;HIV Infections;HIV/AIDS;improved;Inflammation;Infrastructure;interest;Intervention;Laboratories;Lead;Leadership;Lung;meetings;Mentored Clinical Scientist Development Program;Mentorship;Metabolic Pathway;metabolomics;Metagenomics;microbial;microbiome;microbiome research;modifiable risk;Monitor;mortality risk;multidisciplinary;National Heart, Lung, and Blood Institute;National Institute on Alcohol Abuse and Alcoholism;nutrition;Oxides;Persons;Policies;Population;Preparation;Probiotics;Procedures;program dissemination;Program Research Project Grants;programs;Progress Reports;Protocols documentation;Publications;Randomized, Controlled Trials;recruit;Research;Research Personnel;Resources;Risk Factors;Russia;Services;Site;Sleep;Specimen;synergism;Teacher Professional Development;Testing;Training;Training Programs;Translational Research;trial design;trimethyloxamine;Uganda;United States National Institutes of Health;Universities;University resources;Veterans;Volatile Fatty Acids;Work;Zinc

PROJECT_TITLE: Administrative, Education, and Analytic Support Core


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Cellular identity and function is determined by gene regulation steps, including pre-mRNA splicing that dictates which protein-coding exons will be incorporated into mRNAs. Neuronal genes are enriched in tiny “microexons” required for proper brain development; failure to include microexons is associated with autism. Here, I will use novel methods to identify how microexons are recognized and spliced into mRNA during transcription.

PI_NAMEs: GORDON, JACKSON  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: 5' Splice Site;Address;Alternative Splicing;autism spectrum disorder;Biology;Brain;cell type;Cells;Code;Codependence;Coupled;Data;Development;DNA-Directed RNA Polymerase;Engineering;Erythroid Cells;Event;Excision;Exons;experimental study;Failure;Gene Expression Regulation;Genes;Genetic Enhancer Element;Genetic Transcription;in vivo;Introns;Length;Libraries;Link;Messenger RNA;Methods;Molecular;mRNA Precursor;Nervous System;Nervous System Disorder;neuron development;Neurons;Neurotransmitters;novel;Nucleotides;Patients;Play;Polyadenylation;Polymerase;Positioning Attribute;Precision Run-On Sequencing;Protein Isoforms;Proteins;receptor;Regulation;Reporter;RNA;RNA Polymerase II;RNA Processing;RNA Splicing;Role;Series;Signal Transduction;single molecule;Site;Study models;System;Tail;Time;Tissues;Transcript;Transcription Elongation;Transcription Initiation Site;transmission process;Variant;Work;Yeasts

PROJECT_TITLE: Co-transcriptional mechanisms of neuronal microexon splicing: causes and consequences for 3' end processing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Hematology;Pediatric;Rare Diseases;Sickle Cell Disease

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: Project Narrative (3 sentences) Sickle Cell Disease (SCD) is a growing global public health issue, necessitating the need for increased research to develop effective therapies towards improving quality of life and care for SCD patients, through scientifically rigorous methods such as cohort studies, which improve our understanding of risk factors, health and disease outcomes. High disease prevalence of SCD in sub-Saharan Africa (SSA) should facilitate epidemiologic, translational, and clinical research studies on well-coordinated longitudinal cohorts, similar to the Framingham Study for heart disease, and this U24 application is seeking to renew the Sickle Africa Data Coordinating Center (SADaCC) grant to support such studies through activities of the SCD SSA Network. We believe that our prior successful experience in implementing SADaCC activities over the past 3 years; the outstanding institutional environment at the University of Cape Town; and our team’s track record and expertise in complementary basic, translational & clinical research and training focused on SCD in SSA; has the potential to strengthen the effectiveness of SADaCC to support the SCD SSA Network and drive SCD research for better health outcomes.

PI_NAMEs: MULDER, NICOLA ;WONKAM, AMBROISE  (contact)

PROGRAM_OFFICER_NAME: LOUDEN, ANDREW

PROJECT_TERMS: 5 year old;Abnormal coordination;Adult;Africa;Africa South of the Sahara;African;Basic Science;Big Data Methods;Bioinformatics;biomedical informatics;Birth;Caring;Cellular Phone;Child;Clinical Research;cohort;Cohort Studies;Communication;Country;dashboard;Data;Data Collection;Data Coordinating Center;Data Element;data management;data quality;Data Set;data standards;Databases;Death Rate;design;Development;Disease;Disease Outcome;effective therapy;Effectiveness;Electronics;Ensure;Environment;epidemiology study;Ethics;Evaluation;experience;Framingham Heart Study;Ghana;Grant;Guidelines;Health;Heart Diseases;Hemoglobinopathies;Human Subject Research;improved;Incidence;Income;Infant;innovation;Institution;International;Intervention;Intranet;life span;Longitudinal cohort;Maintenance;meetings;Methods;Monitor;Neonatal Screening;Nigeria;Online Systems;Ontology;Organ;Outcome;Patients;Peer Review;peer support;Penicillins;Performance;Prevalence;preventable death;Procedures;programs;Prophylactic treatment;Public Health;Publications;Quality of life;recruit;Regional Disease;Registries;Regulation;Reporting;repository;Research;Research Activity;Research Design;research study;Research Support;Risk Factors;Secure;Sickle Cell Anemia;sickling;Site;Site Visit;Standardization;success;Support Groups;System;Tablets;Tanzania;Training;Translational Research;Universities;Update;web site;Writing

PROJECT_TITLE: Sickle Africa Data Coordinating Center


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cardiovascular;Complementary and Integrative Health;Dietary Supplements;HIV/AIDS;Heart Disease;Infectious Diseases;Microbiome;Substance Misuse

PHR: The goal of the Integrated Metagenomics and Metabolomics Core (IMMC) is to provide a platform that interconnects and supports the analytical needs of Projects 1 and 2. Specifically, IMMC will provide high- quality data on gut bacteria and their metabolites and support the assessment of the efficacy of the probiotics supplementation in improving clinical outcomes in people living with HIV (PLWH) with heavy alcohol drinking.

PI_NAMEs: BARVE, SHIRISH S (contact)

PROJECT_TERMS: Affect;Aging;Alcohol consumption;alcohol research;Alcohols;Amines;Bile Acids;biobank;Bioinformatics;Biological Specimen Banks;Boston;Cardiovascular Diseases;Cessation of life;Clinical;clinical care;cohort;Cohort Studies;Collaborations;college;Communities;comorbidity;Complement;Computational algorithm;Data;Data Analyses;data integration;data management;data mining;data repository;data sharing;data standards;Development;dysbiosis;efficacy evaluation;Ensure;Equipment and supply inventories;Evaluation;Fostering;Generations;Genes;Goals;gut bacteria;gut dysbiosis;gut microbiota;Heavy Drinking;HIV;HIV Infections;HIV/AIDS;host microbiota;Human Resources;improved;Infrastructure;innovation;Institution;Letters;Logistics;Longitudinal Studies;Longitudinal, observational study;Mass Fragmentography;Medicine;metabolome;metabolomics;metagenomic sequencing;Metagenomics;Methods;microbial;microbiome;microbiome research;microbiota;Molecular;Monitor;National Cancer Institute;National Institute on Alcohol Abuse and Alcoholism;Nomenclature;Outcome;Output;Oxides;Participant;Persons;Plasma;Preparation;probiotic supplementation;Probiotics;Procedures;programs;Publishing;Quality Control;randomized, clinical trials;Recording of previous events;Research Design;Research Personnel;Research Project Grants;Resources;RNA;Role;rRNA Genes;Russia;sample collection;Sampling;Sampling Studies;Serum;Shipping;Shotguns;Site;Specimen;Standardization;stool sample;Taxon;Techniques;Therapeutic;Uganda;Universities;Veterans;Volatile Fatty Acids;whole genome;Work

PROJECT_TITLE: Integrated Metagenomic and Metabolomic Core


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Genetics;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative: Endothelial regulation of astrocyte trans-differentiation in stroke  The generation of new brain cells called neurons (i.e. neurogenesis) plays an important role in stroke recovery. Here, we will investigate a novel phenomenon whereby cells from blood vessels in the brain (i.e. brain endothelium) can release unexpected molecular signals that convert a different type of brain cell called astrocytes into newborn neurons, thus augmenting neurogenesis and improving functional outcomes after stroke. Understanding the mechanisms of this new blood vessel-regulated phenomenon of neurogenesis may open up new opportunities for pro-recovery therapies in stroke patients.

PI_NAMEs: LO, ENG H. (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: adeno-associated viral vector;Adult;Astrocytes;Blood Vessels;brain cell;brain endothelial cell;Brain Injuries;Brain region;brain repair;Calcium;Cell Culture Techniques;cell type;Cells;Cerebral endothelium;Cerebral Ischemia;Cerebrovascular system;Coculture Techniques;Cognitive;Data;deprivation;DNA;Down-Regulation;Embryo;Endothelial Cells;Endothelium;Etiology;Event;Excision;experimental study;Female;foot;functional improvement;gain of function;Gene Expression;Generations;Genes;Glial Fibrillary Acidic Protein;Glucose;Human;Image;improved;improved outcome;In Vitro;in vivo;in vivo calcium imaging;in vivo optical imaging;Infarction;Ischemia;ischemic injury;Knock-out;Liposomes;loss of function;male;Maps;Measures;Mediating;Methods;Microglia;microvesicles;Modeling;Molecular;mouse genetics;Mus;nerve stem cell;neural;neurogenesis;Neuronal Plasticity;Neurons;neurovascular;neurovascular unit;newborn neuron;novel;novel therapeutics;Outcome;overexpression;Oxygen;Pericytes;Play;polysialyl neural cell adhesion molecule;Population;post stroke;Potassium;Process;programs;promoter;Proteins;Rattus;Recovery;Regulation;Reporting;response;Reverse Transcriptase Polymerase Chain Reaction;RNA;Role;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Small Interfering RNA;Sodium;Source;Stains;Stroke;stroke patient;stroke recovery;subventricular zone;Synapses;Tamoxifen;Testing;Therapeutic;Therapeutic Effect;Time;tissue repair;tool;transcription factor;transcriptome;transcriptome sequencing;transdifferentiation;Up-Regulation;Virus Diseases

PROJECT_TITLE: Endothelial Regulation of Astrocyte Trans-Differentiation in Stroke

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;HIV/AIDS;Heart Disease;Infectious Diseases;Microbiome;Nutrition;Prevention;Substance Misuse

PHR: Among people living with HIV, heavy drinking increases the risk of heart disease and death. Studies suggest that alcohol changes the number and kind of bacteria in your gut and these changes increase the risk of heart disease and death. This randomized controlled trial will determine whether a pill containing healthy gut bacteria can increase the number good bacteria in the gut, lower levels of inflammation, and lower the risk of heart disease and death.

PROJECT_TERMS: Acids;Aging;Alcohol consumption;alcohol effect;alcohol intervention;alcohol research;Alcoholic beverage heavy drinker;Alcohols;Amines;antiretroviral therapy;arm;Bacteria;bile acid metabolism;Bile Acids;Biological Markers;Biometry;Blood specimen;Butyrates;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;cardiovascular risk factor;CD4 Lymphocyte Count;Cells;Cessation of life;Cholic Acids;Circulation;Cohort Studies;Collaborations;Counseling;Data;data management;Deoxycholic Acid;Disease;Disease Progression;disorder risk;dysbiosis;epidemiology study;evidence base;Family;Fibrin fragment D;Firmicutes Bacteroidetes ratio;Funding;gut bacteria;gut dysbiosis;gut microbiome;heart disease risk;Heavy Drinking;high risk;HIV;improved;indexing;Inflammation;Interleukin-6;Intervention;Leaky Gut;lipopolysaccharide-binding protein;Measures;Medical;metabolomics;Metagenomics;microbial;microbiome;microbiome research;Modeling;mortality risk;National Institute on Alcohol Abuse and Alcoholism;nutrition;Outcome Study;Oxides;Participant;Patient Self-Report;Persons;pill;Pilot Projects;Placebos;Plasma;Probiotics;Process;Randomized, Controlled Trials;recruit;Reporting;Research;Risk;Risk Factors;Role;Russia;Site;Testing;trial design;United States National Institutes of Health;Universities;Veterans;Work;Zinc

PROJECT_TITLE: Microbiome, metabolites, and alcohol in HIV to reduce CVD RCT (META HIV CVD RCT)


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DURHAM

ORG_NAME: UNIVERSITY OF NEW HAMPSHIRE

ORG_STATE: NH

PHR: The University of New Hampshire’s first COBRE: Center of Integrated Biomedical and Bioengineering Research (CIBBR) has substantially improved the biomedical and bioengineering research environment during Phase 1, as evidenced by the number of research project grant awards and publications by CIBBR investigators, the career advancement of CIBBR faculty, and major investments in biomedical research infrastructure. Building upon these accomplishments, the overall goal of CIBBR in Phase 2 is to expand the Center’s research portfolio through continued hiring of new biomedical and bioengineering faculty, creation of a new Data Science Core, acquisition of new instruments in conjunction with a business plan, and enhancements to the mentoring program and administrative operations. These actions will have a powerful and sustained impact on biomedical and bioengineering research at UNH by increasing our knowledge of basic biomedical science and bioengineering, expediting the development of clinically relevant diagnostic tools and treatments, and advancing biomedical workforce training capacity in the state of New Hampshire.

PI_NAMEs: COTE, RICK H (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Acceleration;Advisory Committees;Advocate;Area;Award;Biomedical Engineering;Biomedical Research;Businesses;career;career development;Career Mobility;Centers of Research Excellence;clinical development;clinically relevant;Collaborations;Communication;Computational Biology;Core Facility;Data Science Core;Dedications;Development;diagnostic tool;early-career faculty;Ecosystem;Educational workshop;Effectiveness;effectiveness research;Environment;Evaluation;Faculty;faculty mentor;Faculty Recruitment;Funding;Goals;Grant;Health;Human;improved;Infrastructure;innovation;Institution;instrument;instrumentation;Interdisciplinary Study;Investments;Knowledge;Leadership;Measurement;Mentors;model design;Molecular;multidisciplinary;multiple omics;New Hampshire;operation;Operations Research;Outcome;Performance;Phase;Phenotype;Pilot Projects;Program Development;Program Evaluation;programs;Publications;recruit;Research;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Science;Services;Technology;Training;Translations;United States National Institutes of Health;Universities


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Prevention

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative—Health Relevance This project will identify pharmacological interventions that improve the length of life and/or the quality of aging in a simple animal model that shares many hallmark features of aging in humans. Data obtained at three assay sites by rigorously testing a genetically diverse test set is anticipated to identify chemical treatments with high potential to be efficacious in a diverse human population. Our study may lead to treatments that protect against physical deterioration, cognitive decline, and disease susceptibility in the elderly human population.

PI_NAMEs: DRISCOLL, MONICA A. (contact)

PROGRAM_OFFICER_NAME: FOX, JENNIFER THERESA

PROJECT_TERMS: Acceleration;Age;age-related disease;Aging;aging process;American;Animal Model;anti aging;Biological Assay;Biological Models;Biology of Aging;Caenorhabditis;Caenorhabditis elegans;Caregivers;Chemicals;Chronic Disease;Chronology;Clinical Research;Clinical Sciences;Collection;Communities;community setting;Data;Data Set;Databases;Dementia;design;Deterioration;Diabetes Mellitus;Disease;Disease susceptibility;Economics;efficacy testing;Elderly;Engineering;Evaluation;experimental study;extend lifespan;Gene Deletion;Gene Expression Regulation;Genes;Genetic;Genetic Drift;Genetic Heterogeneity;genome editing;Goals;hallmarks of aging;Health;Healthcare Systems;healthspan;healthy aging;Heart;Heterogeneity;Human;human old age (65+);Impaired cognition;Impairment;improved;Individual;innovation;Intervention;intervention program;Laboratories;late life;Life;life span;Link;Literature;Locomotion;Longevity;Maintenance;Malignant Neoplasms;Medical Research;Metabolism;Mitochondria;Modeling;mortality;Mus;Nematoda;Neurodegenerative Disorders;novel;Oregon;Outcome;Pathway interactions;Pattern;pharmacologic;Population;Population Heterogeneity;pre-clinical;pre-clinical research;Privatization;Process;programs;proteostasis;Quality of life;rate of aging;Recommendation;Reporting;Reproducibility;Research;Resistance;Resolution;response;Risk;Risk Factors;Science;screening;Signal Transduction;Site;Societies;Stress;success;System;Systems Analysis;Testing;therapy development;transcriptome sequencing;Translating;Translations;Validation;Variant;Virus Diseases;whole genome;Work

PROJECT_TITLE: Caenorhabditis Intervention Testing Program:  Interventions That Modulate Health, Longevity and Aging Hallmarks


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Advisory Committees;Award;base;Biomedical Engineering;Biomedical Research;Biometry;career development;Career Mobility;Centers of Research Excellence;Clinical;Clinical Research;Collaborations;commercialization;Computational Biology;Core Facility;cost;Data Analytics;data management;Data Science Core;Development;Ecosystem;Educational workshop;Effectiveness;effectiveness research;Environment;Evaluation;Faculty;Funding;Future;Grant;human disease;improved;Incentives;Interdisciplinary Study;Investments;Leadership;meetings;Mentors;Modeling;Molecular;multiple omics;New Hampshire;operation;outreach;Pathway interactions;Peer Review;Phase;Phenotype;Pilot Projects;professor;programs;Publications;recruit;Research;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;tenure track;therapy development;Training Programs;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: CIBBR Administrative Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: BIRMINGHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE We have determined that pneumonia severity during Streptococcus pneumoniae (Spn) and influenza superinfection is increased as result of Pneumococcal surface protein A (PspA) binding to dying host cells. We will determine the molecular basis for this interaction. We will determine how this property of PspA influences Spn localization within the airway, bacterial outgrowth, and learn the importance of sloughed Spn/dying nasopharyngeal epithelial cell aggregates on transmission.

PI_NAMEs: ORIHUELA, CARLOS J (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Adhesions;Affinity;airway epithelium;Animals;Antibodies;Apoptosis;Bacteria;Bacterial Adhesins;Binding;Biological;Caspase;Cell Aggregation;Cell Death;Cells;co-infection;Complement;Cytolysis;Data;Desiccation;Development;Disease;Disease Progression;Epithelial Cells;experience;Family;Immune;Inflammation;Influenza;Influenza A virus;influenzavirus;Learning;Length;Lung;Mediating;Membrane;Membrane Proteins;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;mutant;Nasopharynx;neonatal mice;Nose;novel;Nutrient;pathogen;Persons;Phosphatidylserines;Pilot Projects;Pneumococcal Infections;Pneumococcal Pneumonia;pneumococcal surface protein A;Pneumonia;Predisposition;Property;Publishing;Research;Resistance;Role;Secondary Prevention;Severities;Severity of illness;Streptococcus pneumoniae;Streptococcus pneumoniae plY protein;superinfection;Surface;synergism;Testing;Toxin;transmission process;Variant;Virulence;Virus;Virus Diseases;Work

PROJECT_TITLE: PspA binds necroptotic cells to cause disease and transmit

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-R(02)M]


PI_NAMEs: WOJCHOWSKI, DON MICHAEL (contact)

PROJECT_TERMS: Address;Adoption;base;Biocompatible Materials;Biomedical Engineering;Biomedical Research;Businesses;Centers of Research Excellence;Charge;Communities;Contract Services;cost;Data;Data Analyses;data management;Data Science Core;data sharing;Dedications;Educational workshop;Ensure;Equipment;equipment acquisition;Experimental Designs;Fee Schedules;Funding;Future;Goals;Health;high resolution imaging;Human;Infrastructure;innovative technologies;Institution;instrument;instrumentation;Interdisciplinary Study;Investments;Knowledge;Laboratories;Life Cycle Stages;Maintenance;mass spectrometer;Measures;Microscope;Molecular;Molecular and Cellular Biology;Molecular Biology;nano;new technology;Phase;Phenotype;Productivity;programs;Proteomics;Protocols documentation;Recovery;Reproducibility;Research;research faculty;Research Infrastructure;Research Personnel;Research Support;Roentgen Rays;Schedule;skills;System;Techniques;Training;Translating;Translational Research;ultra high resolution;Universities

PROJECT_TITLE: Molecular and Cellular Phenotyping (MCP) Core


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Cardiovascular;Clinical Research;HIV/AIDS;Heart Disease;Microbiome;Substance Misuse

PHR: Unhealthy alcohol consumption and HIV infection are independently linked to heart disease, so people with HIV who drink heavily are at very high risk for heart disease. Alcohol changes the gut bacteria (called the microbiome) which in turn changes their breakdown products, decreasing beneficial products and increasing harmful ones. This study will test whether alcohol's effects on the gut bacteria and the resulting changes in breakdown products contribute to heart disease in people with HIV who drink heavily.

PI_NAMEs: SO-ARMAH, KAKU  (contact)

PROJECT_TERMS: adjudication;Aging;Alcohol consumption;alcohol effect;alcohol misuse;Alcoholic beverage heavy drinker;Alcohols;Amines;Bacteria;Bile Acids;Biological Markers;Blood;Butyrates;Cardiac;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;Cells;Cessation of life;Cholic Acids;Choline;clinical care;clinical trial participant;cohort;Cohort Studies;Collaborations;Colon;comorbidity;Coronary;Data;Deoxycholic Acid;drinking;dysbiosis;Dyslipidemias;Echocardiography;epidemiology study;Evaluation;Event;Functional disorder;Funding;gastrointestinal;Goals;gut bacteria;gut dysbiosis;gut microbiome;Health;heart disease risk;Heart Diseases;Heart failure;Heavy Drinking;high risk;HIV;HIV Infections;Immune System Diseases;Inflammation;Inflammatory;Insulin Resistance;Intervention;Intestinal permeability;Intestines;Ischemic Stroke;Justice;Kidney;Letters;Link;Lipids;Liver;Metabolic Pathway;Metabolism;metabolomics;microbial;microbial composition;microbiome;Modeling;Morbidity - disease rate;mortality;mortality risk;Myocardial dysfunction;Myocardial Infarction;new therapeutic target;observational cohort study;Observational Study;Organ;Oxides;Pathway interactions;Peripheral arterial disease;Persons;primary outcome;Probiotics;Production;Program Research Project Grants;prospective;Regulatory T-Lymphocyte;response;revascularization;T-Lymphocyte Subsets;Testing;therapeutic target;United States National Institutes of Health;Update;Veterans;Volatile Fatty Acids;Work;X-Ray Computed Tomography

PROJECT_TITLE: Microbiome, metabolites, and alcohol in HIV to reduce CVD Cohort (META HIV CVD Cohort)


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: THOMAS, W KELLEY  (contact)

PROJECT_TERMS: Address;Adopted;Adoption;Applications Grants;Area;base;Bioinformatics;Biomedical Engineering;Biomedical Research;Biometry;Businesses;career;Centers of Research Excellence;Client;cloud based;Cloud Computing;Collaborations;Communities;Computational Biology;computing resources;Core Facility;cost;cost effective;Data;data acquisition;Data Analyses;Data Analytics;data infrastructure;data management;Data Science;Data Science Core;Data Set;data submission;Deposition;diagnostic screening;Ecosystem;Educational workshop;Ensure;Experimental Designs;FAIR principles;Fee-for-Service Plans;Genome;Genomics;Infrastructure;innovation;innovative technologies;Institution;instrumentation;Interdisciplinary Study;Investments;Life Cycle Stages;Methods;Modeling;molecular diagnostics;multidisciplinary;Multiomic Data;multiple omics;New Hampshire;new technology;operation;Phase;programs;Recovery;repository;Reproducibility;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;searchable database;Services;Source;Statistical Data Interpretation;Technology;Training;training opportunity;Training Programs;Universities;voucher

PROJECT_TITLE: Data Science Core


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: MANGILAO

ORG_NAME: UNIVERSITY OF GUAM

ORG_STATE: GU

PHR: PROJECT NARRATIVE: OVERALL The Pacific Island Partnership for Cancer Health Equity (PIPCHE) represents the next step in augmenting a Hawai‘i-Guam-USAPI cancer research infrastructure by investing in Pacific Island Populations leaders, Early Stage Investigators, community partners, and community-informed disparities research. As a result of the 17- year commitment, PIPCHE is also well positioned to increase the diversity of the biomedical cancer science workforce and research leadership that better reflects the Hawai‘i-Guam-USAPI larger racial/ethnic representation and to stimulate new areas of disparities and translational research. PIPCHE has assembled dedicated academic and community partnerships needed to synergistically accelerate disparities research into a sustainable forum that pursues cultural and environmental appropriate solutions.

PI_NAMEs: HATTORI, MARGARET P;LEON GUERRERO, RACHAEL T (contact);PALAFOX, NEAL A.;PAULINO, YVETTE C

PROGRAM_OFFICER_NAME: GHOSH, SANGEETA AHUJA

PROJECT_TERMS: Acceleration;Accreditation;Address;adolescent smoking;Advanced Malignant Neoplasm;Affect;American;anti-cancer research;Area;Areca;Asian;Awareness;Behavioral;Biological;Biology;Biometry;Cancer Burden;Cancer Center;Cancer Control;cancer education;Cancer Etiology;cancer health disparity;Cancer health equity;cancer prevention;Cancer Research Infrastructure;Cancer Research Project;cancer risk;Cancer Science;Clinical;Clinical Trials;Collaborations;Communities;Community Health;community organizations;Community Outreach;community partners;community partnership;Complex;Country;cultural competence;Dedications;Disparity;Distant;Economics;Education;education research;Enrollment;Environment;Epidemiology;Equity;Ethnic Origin;Evaluation;evidence base;expectation;Extramural Activities;Faculty;Funding;geographic population;Goals;Guam;Hawaii;Health;health care availability;health determinants;Health Educators;health equity;Health equity research;health literacy;Health Personnel;Health Sciences;Health system;higher education;improved;Incidence;Individual;Information Technology;Infrastructure;insight;Institution;Investments;Island;Knowledge;Leadership;Learning;Life Style;Location;malignant mouth neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant Neoplasms;Marshall Islands;Mastication;member;Mentors;Minority;Minority-Serving Institution;Modeling;mortality;National Cancer Institute;NCI-Designated Cancer Center;neoplasm registry;Nuts;Obesity;Outcome;outreach;Pacific Island Americans;Pacific Islander;Pacific Islands;Pilot Projects;Policies;Population;population health;Positioning Attribute;Poverty;Prevention;Process;programs;psychosocial;public health intervention;Race;recruit;Research;Research Personnel;Research Project Grants;Research Training;Resource Sharing;Resources;Risk Factors;Screening for cancer;Series;Site;social;Socioeconomic Status;Students;Surveys;Survival Rate;Training;Translational Research;Underserved Population;United States;Universities;Work;Workforce Development

PROJECT_TITLE: (2/2) Pacific Island Partnership for Cancer Health Equity (PIPCHE)


NIH_SPENDING_CATS: Cancer;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: LEON GUERRERO, RACHAEL T (contact)

PROJECT_TERMS: Advisory Committees;anti-cancer research;Cancer Center;Cancer health equity;career development;Collaborations;Communication;community advisory board;design;Development;Educational workshop;Effectiveness;Environment;Evaluation;Goals;Guam;Hawaii;Indigenous;Infrastructure;Institution;Leadership;Malignant Neoplasms;meetings;Mission;NCI-Designated Cancer Center;Office of Administrative Management;Pacific Islander;Pacific Islands;Population;Preparation;programs;Progress Reports;Recommendation;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resource Allocation;Resource Sharing;Science;Services;Universities;Vision

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Advisory Committees;anti-cancer research;Cancer Center;cancer health disparity;Cancer health equity;Charge;Collaborations;community advisory board;Community Outreach;Data;Development;Disparity;Education and Outreach;education research;Ensure;Evaluation;Faculty;Feedback;Funding;Funding Opportunities;Future;Goals;Grant;Guam;Hawaii;Health equity research;improved;inter-institutional;International;Leadership;Malignant Neoplasms;meetings;member;Monitor;Outcome;Pacific Islander;Pacific Islands;Persons;Pilot Projects;Population;Process;programs;Recommendation;Research;Research Personnel;Research Project Grants;Resources;response;Site;Specialist;Strategic Planning;success;Universities

PROJECT_TITLE: Planning and Evaluation Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Comparative Effectiveness Research;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Hypertension;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Sepsis;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The overarching goal of this project is to leverage electronic health record (EHR) data to determine to what degree recommended safety practices and clinical management for (i) severe hypertension, (ii) obstetric hemorrhage, (iii) sepsis, and (iv) frankly abnormal vital signs are associated with decreased risk for a major complication or death (failure to rescue). This project will model maternal care in high-risk scenarios using EHR data to provide novel insights on quality and outcomes that could be scalable across hospitals and facilitate safety improvement.

PI_NAMEs: FRIEDMAN, ALEXANDER M (contact);ROSSETTI, SARAH COLLINS

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Acute Kidney Failure;Address;Adherence;adverse maternal outcomes;adverse outcome;Affect;behavioral phenotyping;billing data;Biometry;Blood Banks;burden of illness;Caring;Cessation of life;Clinical;clinical development;Clinical Management;Clinical Research;clinical risk;Clinical Trials;comorbidity;Complex;Complication;Country;Data;Data Analyses;data standards;Decision Analysis;design;Deterioration;Development;Devices;Diagnosis;Discipline of obstetrics;Eclampsia;economic evaluation;Electronic Health Record;Emergency Situation;Event;evidence base;Failure;Goals;Guidelines;Hemorrhage;high risk;Hospitalization;Hospitals;Hypertension;Hysterectomy;implementation science;improved;Individual;Infection;Informatics;innovation;insight;Intervention;Knowledge;Leadership;Lifelong disability;Manuals;maternal morbidity;Maternal Mortality;maternal risk;maternal safety;Measures;Medical;medical complication;Methodology;Modeling;mortality;multidisciplinary;novel;obstetric care;Organ;Outcome;Outcome Assessment;Patient risk;patient stratification;Patients;Perinatal;Perinatal Epidemiology;Pharmaceutical Preparations;Phenotype;Population;Postpartum Hemorrhage;Practice Management;pregnancy hypertension;prevent;Procedures;Protocols documentation;Provider;provider behavior;quality assurance;Quality of Care;racial disparity;Radiology Specialty;Recommendation;Records;Research;Resources;response;Risk;Risk Estimate;Risk Reduction;risk stratification;Safety;safety assessment;safety practice;Secondary to;Sepsis;service coordination;severe maternal morbidity;Severities;simulation;Standardization;standardized care;Stroke;System;systematic review;Testing;Time;trend;Variant

PROJECT_TITLE: Modeling informatics data to track maternal risk and care quality

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: AMES, TODD  (contact)

PROJECT_TERMS: Address;anti-cancer research;Applications Grants;Asian Pacific Islander;Asian population;Cancer Burden;Cancer Center;Cancer Control;cancer health disparity;Cancer health equity;cancer prevention;Cancer Research Center of Hawaii;career;career development;Caucasians;Collaborations;Communities;community based research;community intervention;curriculum enhancement;Degree program;Development Plans;Distant;doctoral student;Economics;Education;education research;Educational Curriculum;Educational workshop;Enrollment;Epidemiology;ethnic disparity;ethnic diversity;Ethnic Origin;experience;Faculty;follow-up;Funding;Future;Geographic Locations;Geography;Goals;Graduate Degree;graduate student;Grant;Guam;Hawaii;Health;health disparity;Health equity research;improved;Incidence;Individual;Institution;interest;Intervention;Island;Journals;Location;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant Neoplasms;Manuscripts;Master of Science;meetings;member;Mentors;Micronesia;minority health disparity;mortality;novel;online course;Output;Pacific Islander;Pacific Islands;Pathway interactions;Peer Review;Population;Positioning Attribute;Postdoctoral Fellow;programs;psychosocial;Publications;Publishing;Race;Research;Research Assistant;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Scholarship;Series;skills;Students;success;Supervision;Time;Training;Training Activity;Travel;Underserved Population;Universities;Writing

PROJECT_TITLE: Research Education Core


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

PI_NAMEs: WALKER, SARAH  (contact)

PROJECT_TERMS: Address;ATAC-seq;BCL6 gene;Binding;Binding Proteins;Binding Sites;Biological;Biological Markers;biomarker identification;Biomedical Engineering;Biotinylation;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;Breast Cancer therapy;cancer cell;cancer type;CDH1 gene;cell growth;Cell Line;Cell Proliferation;Cells;chemotherapy;ChIP-seq;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Computer Analysis;Core Facility;Data;Data Analyses;Disease;DNA Binding;epithelial to mesenchymal transition;Event;Family member;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Genome;genomic locus;Genomics;Goals;Growth;Human;In Vitro;in vivo;inhibitor;Lead;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mass Spectrum Analysis;MDA MB 231;MDA-MB-468;Mediating;Mediator;Methods;migration;Molecular;Molecular Target;mouse model;mutant;novel;novel therapeutic intervention;Pathogenesis;Pathogenicity;Patients;Phosphotransferases;Play;Positioning Attribute;Prognosis;Proteins;recruit;Regulation;Research;response;Sampling;single-cell RNA sequencing;Site;Stat3 protein;Stat5 protein;Survival Rate;tenure track;Testing;TFAP2C gene;Therapeutic;transcription factor;treatment response;treatment strategy;triple-negative invasive breast carcinoma;tumor;upstream kinase;Use of New Techniques;Work

PROJECT_TITLE: Modulation of STAT3 activity by STAT5 in triple negative breast cancer


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE Pacific Islanders are one the fastest growing ethnic groups in the US, found in every state. The work of the Pacific Island Partnership for Cancer Health Equity’s (PIPCHE) Community Outreach Core (COC) directly addresses the disproportionately high rates of cancer incidence and mortality found among Pacific Island Populations (PIP) in Hawai‘i and Guam. Using community-engaged approaches, the Community Outreach Core will work to support, enhance, and disseminate the PIPCHE’s research to better understand the determinants of cancer in this group. The COC’s activities will also serve to reduce the burden of preventable cancers found in PIP living in Hawai‘i and Guam, which may be applicable to groups found elsewhere in the US.

PI_NAMEs: SOMERA, LILNABETH  (contact)

PROJECT_TERMS: Achievement;Address;anti-cancer research;Areca;Awareness;Behavior;Biological;Cancer Control;cancer health disparity;Cancer health equity;cancer prevention;cancer risk;care providers;Cause of Death;Cervical Cancer Screening;Clinical Trials;Collaborations;Colorectal Cancer;colorectal cancer screening;Communities;community engaged approach;community organizations;Community Outreach;Competence;Complex;Death Rate;design;Education;Equity;Ethnic Population;evidence base;experience;Failure;Filipino;Goals;Guam;Hawaii;Health;Health Educators;Health equity research;Health Personnel;Health Professional;high risk behavior;Human Papilloma Virus Vaccination;improved;Incidence;Knowledge;malignant mouth neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;men;mortality;Nuts;Outcome;outreach;Pacific Islander;Pacific Islands;parity;Population;population based;Population Group;Prevention;Program Sustainability;Provider;recruit;Research;Research Personnel;Research Project Grants;Research Training;Resource Development;Resources;Risk Reduction Behavior;Screening for cancer;social determinants;Students;Surveys;Tobacco;Training;underserved minority;uptake;Work

PROJECT_TITLE: Community Outreach Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Digestive Diseases;Liver Disease;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE The successful outcome of this Co-Clinical Imaging Research Program proposal is the establishment of an online resource of quantitative HP 13C MRI protocols, data analyses tools, and correlative biology data allowing for a consensus on how quantitative HP 13C MRI can be used in co-clinical imaging trials to improve the assessment of therapeutic response and resistance. While this project focuses on advanced prostate cancer, these new quantitative metabolic imaging techniques could ultimately benefit the clinical management of other cancers and diseases.

PI_NAMEs: KURHANEWICZ, JOHN  (contact);PEEHL, DONNA M.;SRIRAM, RENUKA

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: 2,4-Dinitrophenol;Address;advanced prostate cancer;analytical tool;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;anti-cancer research;Basic Science;Biological Markers;Biology;Biopsy;Blood Tests;bone;Bone Diseases;cancer clinical trial;Cancer Detection;Carboplatin;chemotherapy;Clinical;clinical imaging;Clinical Investigator;Clinical Management;Clinical Protocols;Clinical Research;Clinical Trials;co-clinical trial;Communities;Consensus;conventional therapy;Data;data acquisition;Data Analyses;data modeling;data repository;data standards;Disease;Echo-Planar Imaging;Elements;Event;fluorodeoxyglucose;Funding;Generations;Genetic;Goals;Grant;Heterogeneity;Image;imaging approach;Imaging Device;imaging informatics;imaging modality;imaging study;Imaging Techniques;improved;improved outcome;in vivo;Informatics;informatics infrastructure;Information Resources;inhibitor;Liver;Liver diseases;Magnetic Resonance;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;men;Metabolic;metabolic imaging;metabolic profile;Metastatic Neoplasm to the Bone;Metastatic Neoplasm to the Liver;Metastatic Prostate Cancer;Methods;Modeling;Molecular;mouse model;Mus;Neoplasm Metastasis;Neuroendocrine Cell;Neuroendocrine Prostate Cancer;Neuroendocrine Tumors;Neurosecretory Systems;new therapeutic target;next generation;Noise;novel;Oncology;online repository;online resource;Outcome;Pathologic;Pathway interactions;patient derived xenograft model;patient response;Patients;Physiologic pulse;Platinum;Positron-Emission Tomography;pre-clinical;preclinical development;Prediction of Response to Therapy;predictive marker;Process;programs;Protocols documentation;Pyruvate;quantitative imaging;radio frequency;real time monitoring;Receptor Signaling;Reproducibility;Research;Research Design;Research Project Grants;Resistance;Resources;response;response biomarker;Serum;Signal Transduction;Site;Somatostatin Receptor;stable isotope;standard of care;Technology;temporal measurement;Testing;Therapeutic Clinical Trial;therapy resistant;tool;transcriptomics;transdifferentiation;translational barrier;Treatment Efficacy;treatment response;tumor xenograft;United States National Institutes of Health;Validation;web portal

PROJECT_TITLE: Co-Clinical Quantitative Imaging of Small Cell Neuroendocrine Prostate Cancer Using Hyperpolarized 13C MRI


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: ONTARIO INSTITUTE FOR CANCER RESEARCH

ORG_STATE: ON

ORG_ZIPCODE: M5G 0A3

PHR: Project Narrative Overture is an open-source software suite designed to help cancer researchers easily manage data in large-scale genome projects at all stages of the data lifecycle. To further this goal, we are developing the Overture Data Management System (DMS) as a turnkey solution that can be extended with visualization tools and analysis platforms while complying with new global standards for user and data access management.

PI_NAMEs: COURTOT, MELANIE ;STEIN, LINCOLN D.;YUNG, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Acceleration;Adoption;Authorization documentation;big data management;Biological Markers;Canada;cancer genome;cancer genomics;Cancer Model;Categories;Child;Clinical;cloud based;cohort;Collaborations;Collection;Communities;community empowerment;community engagement;Computer software;Consent;cost effective;Data;data access;Data Discovery;data exchange;data integration;data management;Data Management Resources;data platform;data portal;data resource;Data Scientist;Data Set;data sharing;Democracy;Dependence;design;Development;Documentation;Educational workshop;European;Event;FAIR principles;Feedback;Focus Groups;Generations;genome-wide;genomic data;Genomic Data Commons;Genomics;Goals;Grant;Health;health data;Human;improved;Individual;Informatics;informatics tool;innovation;interest;International;Internet;Laboratories;large datasets;large scale data;Life Cycle Stages;Malignant Neoplasms;Medical Imaging;Metadata;multiscale data;NCI Center for Cancer Research;novel;Oncology;Ontology;open source;outreach;Pathway interactions;Patients;Protocols documentation;rare cancer;Research;Research Personnel;Resources;Sample Size;Scientific Advances and Accomplishments;Software Engineering;Software Framework;Standardization;symposium;System;Testing;Time;tool;Training;transmission process;user-friendly;Validation;Visualization;Visualization software;web portal;webinar

PROJECT_TITLE: Overture: A Multi-Scale Data Platform for Cancer Genomics Research


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BADOWSKI, GRAZYNA  (contact)

PROJECT_TERMS: Advisory Committees;anti-cancer research;Biometry;Biostatistics Shared Resource;Cancer Center;cancer health disparity;Cancer health equity;cancer risk;Collaborations;Consultations;Data;Data Analyses;data curation;data management;data resource;experience;Exposure to;faculty mentor;Guam;Hawaii;Health Disparities Research;health disparity;Incidence;Information Technology;member;Mentors;Methods;Monitor;novel strategies;outreach;Pacific Islands;Pilot Projects;Population;Prevalence;protective factors;Research;Research Design;Research Infrastructure;Research Project Grants;Resource Sharing;Respondent;Risk Factors;Role;Sampling;Scheme;sound;statistics;Students;Universities

PROJECT_TITLE: Shared Resources - 001: Bio Statistics


NIH_SPENDING_CATS: Cancer;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research

PI_NAMEs: HECHANOVA, MANUEL  (contact)

PROJECT_TERMS: Cancer Center;Cancer health equity;Collaborations;Communication;Communications Media;Communities;Community Outreach;Consultations;Database Management Systems;education research;experience;Funding;Goals;Guam;Hawaii;Health equity research;Health Personnel;Industry;Informatics;Information Technology;Infrastructure;Institution;Maintenance;Malignant Neoplasms;outreach;Pacific Islands;Play;Research;Resource Sharing;Site;social media;student training;training opportunity;Universities;Videoconferencing;web site;Work

PROJECT_TITLE: Shared Resources - 002: Information Technology


PROJECT_TERMS: anti-cancer research;Areca catechu;authority;Cancer Center;cancer health disparity;Cancer health equity;Data;Data Collection;data sharing;Development;Ethnic Population;Funding;Guam;Hawaii;Health Disparities Research;Health equity research;Incidence;Infrastructure;Interview;Joints;male;Malignant neoplasm of liver;Malignant Neoplasms;Mastication;Medical Records;mortality;multi-ethnic;neoplasm registry;Nuts;outreach;Pacific Islands;Patients;Pilot Projects;Play;Publications;Registries;Reporting;Research;Research Project Grants;Research Support;Resource Sharing;Resources;Role;Secure;surveillance data;synergism;Territoriality;Training;tumor registry;Universities

PROJECT_TITLE: Shared Resources - 003: Registry


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Human Genome;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Sleep Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Sleep and circadian rhythm disturbances are prominent features of major depressive disorder (MDD), a highly prevalent and debilitating psychiatric disorder. This project will use a multi-omics approach in human postmortem brain tissue and a mouse model to investigate potential epigenetic mechanisms driving molecular rhythm alterations in the striatum in depression. A better understanding of the mechanisms underlying these molecular rhythm changes may result in the discovery of novel therapeutic targets for future treatments that stabilize circadian disruptions.

PI_NAMEs: KETCHESIN, KYLE  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Affect;Anhedonia;anti-depressive agents;Automobile Driving;Autopsy;Behavior;Behavioral;Bioinformatics;Biometry;Body Temperature;Brain;Brain region;brain tissue;career;career development;Cessation of life;Chronic;Chronic stress;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Cognition;Corpus striatum structure;Data;data integration;Decision Making;depressive symptoms;disability;DNA Integration;DNA Methylation;DNA methylation profiling;DNA methyltransferase inhibition;DNA Modification Methylases;Dorsal;Environment;Environmental Risk Factor;Epigenetic Process;epigenome;epigenomics;Feedback;Funding;Future;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Goals;Hormone secretion;Hour;Human;imaging study;Individual;Laboratories;Lead;Learning;Major Depressive Disorder;Measures;Mental Depression;Mental disorders;Mentors;Mentorship;Midbrain structure;Modification;Molecular;Motivation;mouse model;Multiomic Data;multiple omics;Mus;Neurobiology;new therapeutic target;Nucleus Accumbens;Periodicity;Phase;Positioning Attribute;Process;programs;Psychiatry;putamen;Regulation;Research;Research Personnel;Rest;Rodent;Rodent Model;Role;skills;Sleep;Sleep Wake Cycle;Stress;Technical Expertise;Testing;Time;Tissues;Training;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Universities;Ventral Striatum;Viral

PROJECT_TITLE: Role of DNA methylation in regulating striatal molecular rhythm alterations in depression

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cardiovascular;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE  The inability of the heart to squeeze strong enough to meet the body’s needs is called heart failure and is an expanding health problem. Previous research has demonstrated significant associations between how much fat a person has in the abdomen and the risk for developing heart failure. The purpose of the proposed study is to determine if the quality and quantity of the muscles lining the abdomen and in the mid-thigh are related to several risk factors for heart failure such as physical activity levels.

PI_NAMEs: ALLISON, MATTHEW A (contact);MILJKOVIC, IVA

PROGRAM_OFFICER_NAME: PUGGAL, MONA A

PROJECT_TERMS: Abdomen;Address;Adipose tissue;American;Ankle;Aorta;arterial stiffness;Behavior;blood glucose regulation;Blood specimen;Body Composition;Body measure procedure;Cardiac;Cardiometabolic Disease;cardiometabolic risk;Chronic Disease;Clinic Visits;Deposition;Diabetes Mellitus;Dyslipidemias;EFRAC;Enrollment;Fasting;Fatty acid glycerol esters;Femur;Glucose;Glucose tolerance test;Glycosylated hemoglobin A;Goals;Health;Heart;Heart failure;Hepatic;high risk;Hispanic;Hispanic Americans;Hispanic Community Health Study/Study of Latinos;Hour;Hypertension;indexing;Infiltration;Inflammation;Infrastructure;Insulin;Insulin Resistance;Intervention;Intramuscular;Latino;Left;Left ventricular structure;Life Style;Link;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Medical History;Metabolic syndrome;moderate-to-vigorous physical activity;Muscle;Muscle Fibers;muscle form;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;Obesity;Participant;Pathway interactions;Peripheral arterial disease;Persons;Physical activity;Physiologic pulse;Population;Recording of previous events;recruit;Research;Risk;Risk Assessment;Risk Factors;Risk Reduction;Scanning;Schedule;Science;sedentary lifestyle;Skeletal Muscle;Structure;subcutaneous;Testing;Thigh structure;Thinness;Time;Toes;United States National Institutes of Health;Update;Ventricular End-Systolic Volumes;Visceral;Visit;Work;X-Ray Computed Tomography

PROJECT_TITLE: Activity Levels, Myosteatosis and Insulin Resistance/Diabetes Mellitus

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Neurosciences;Nutrition;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: A substantial number of deaths or permanent disability are contributed by traumatic brain injury (TBI). After the initial primary injury, complex pathophysiological secondary injuries occur over minutes to months with several complex complications, which provides a potential therapeutic window. The overall goal of this proposal is to develop hyperpolarized 13C MRS as a new metabolic imaging tool for the noninvasive diagnosis of TBI metabolism, better understanding of the secondary injury mechanism, and timely therapeutic interventions.

PI_NAMEs: PARK, JAE MO  (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acetates;Acetyl Coenzyme A;Acute;Affect;Age;Animals;Astrocytes;Bicarbonates;Bioenergetics;Brain;Brain Injuries;brain tissue;Carbon;Carbon Dioxide;carboxylation;Cell Respiration;Cerebrum;Cessation of life;Citric Acid Cycle;Clinical;clinical imaging;Closure by clamp;Complex;Data;Disease;Early Diagnosis;effective therapy;Energy Metabolism;Enzymes;Equilibrium;Event;Failure;Fatty Acids;follow-up;Freezing;Functional disorder;Glasgow Coma Scale;Glucose;glucose metabolism;Glutamates;Glutamine;Glycolysis;Goals;Head;high risk;Human;Image;Imaging Device;imaging modality;Impairment;improved;in vivo;in vivo imaging;Individual;Infusion procedures;Injury;Intervention;Ketones;Label;Lifelong disability;magnetic resonance spectroscopic imaging;Measurement;Measures;Mechanics;Metabolic;metabolic imaging;Metabolic Pathway;Metabolism;mild traumatic brain injury;Mitochondria;Modeling;Neurological outcome;Neurons;neuroprotection;Neurotransmitters;Nodal;Non-Invasive Detection;noninvasive diagnosis;oxidation;Oxidative Phosphorylation;Pathologic;Pathway interactions;Patient imaging;Patient-Focused Outcomes;Patients;personalized medicine;Play;potential biomarker;prevent;Process;Production;Pyruvate;Pyruvate Carboxylase;pyruvate dehydrogenase;Pyruvate Metabolism Pathway;Rattus;real-time images;recruit;Role;Scanning;spectroscopic imaging;TBI Patients;Techniques;Therapeutic;Therapeutic Intervention;Tissue Extracts;Tissues;Translating;Traumatic Brain Injury;Tricarboxylic Acids;Unconscious State

PROJECT_TITLE: Pyruvate and acetate metabolism after TBI: implications for cerebral energy metabolism

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Genetics;Orphan Drug;Rare Diseases;Skin Cancer

PI_NAMEs: CHENG, JINGWEI  (contact)

PROJECT_TERMS: Affect;Antineoplastic Agents;Arginine;Automobile Driving;Awareness;Benign;Biological Assay;Biology;Biomedical Engineering;c-myc Genes;cancer clinical trial;cancer drug resistance;cancer therapy;cancer type;carcinogenesis;Carcinoma;cell growth;Cell Line;Cell secretion;ChIP-seq;Clinical;Clinical Trials;Colorectal Cancer;combat;conventional therapy;Data;dimethylarginine;Drug resistance;drug sensitivity;Epigenetic Process;Epithelium;Exhibits;Gastrointestinal Neoplasms;Gastrointestinal Neuroendocrine Neoplasm;Gene Expression;Genomics;Goals;Growth;histone methylation;Histones;Incidence;inhibitor;insight;Lead;Link;Maintenance;Malignant Breast Neoplasm;Malignant Epithelial Cell;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Melanoma;Merkel cell carcinoma;Merkel Cells;Methylation;Modeling;Modification;Molecular;Mutation;N,N-dimethylarginine;Neoplasm Metastasis;Neoplasms;neoplastic cell;Neuroendocrine Cell;neuroendocrine differentiation;Neuroendocrine Therapy;Neuroendocrine Tumors;Neurosecretory Systems;Oncogenic;Organ;paralogous gene;Pathologic;Patients;Pattern;peptide hormone;Phenotype;Polyomavirus;Prevalence;protein arginine methyltransferase 2;protein complex;protein degradation;Protein-Arginine N-Methyltransferase;Radiation;Research;Resistance;response;RNA analysis;Role;Site;Skin;small cell lung carcinoma;small hairpin RNA;stemness;Survival Rate;targeted treatment;Testing;Therapeutic Intervention;therapy development;transcription factor;transcriptome sequencing;transdifferentiation;tumorigenesis;United States;Variant;Viral;Viral Antigens;Virus

PROJECT_TITLE: Targeting PRMT5 to combat cancer drug resistance associated with neuroendocrine differentiation


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Substance Misuse

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: NARRATIVE This research project investigates changes in the abundance of proteins that result from the action of alcohol on a potassium channel during the development of alcohol dependence. This work aims to identify novel molecular determinants of vulnerability to alcohol use disorders.

PI_NAMEs: CONTET, CANDICE  (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Acceleration;Acute;Affect;Affective;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol sensitivity;alcohol use disorder;Alcoholic Intoxication;Alcohols;Alternative Splicing;Amygdaloid structure;Animal Model;Anti-Anxiety Agents;Automobile Driving;Brain;Brain region;Calcium;Calcium Signaling;Chronic;Collaborations;Data;Dependence;Development;Down-Regulation;drinking;Ethanol;Ethanol dependence;Experimental Designs;Exposure to;Habenula;heuristics;Human;In Vitro;in vivo;individual variation;Inhalation;Inhalation Exposure;inter-individual variation;Investigation;knock-down;Knock-in Mouse;Knock-out;Knockout Mice;large-conductance calcium-activated potassium channels;Mass Spectrum Analysis;Mediating;Modeling;Molecular;Molecular Target;Motivation;mouse model;Mus;mutant;Negative Reinforcements;novel;Nuclear;Pathway Analysis;Phase;Population;Post-Translational Protein Processing;Potassium Channel;Prefrontal Cortex;protein expression;Proteins;Proteome;Proteomics;Research Project Grants;response;Risk Factors;RNA Interference;Role;Structure;Testing;Time;Up-Regulation;vapor;Variant;Ventral Tegmental Area;Viral;voltage;Wild Type Mouse;Work

PROJECT_TITLE: Adaptations to chronic activation of BK channels by ethanol: Contribution to dependence and tolerance

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE There are more than 300,000 individuals living with disabilities associated with traumatic spinal cord injury (SCI) in the United States, with approximately 17,000 new cases each year, yet there are no clinically approved treatments to significantly improve outcomes. We have determined that a highly druggable cell surface receptor, the thrombin receptor, can be blocked to improve functional outcomes in experimental SCI models. The proposed experiments will move these findings closer to clinical translation by establishing the efficacy of therapeutic targeting with small molecule inhibitors, providing essential insights into the mechanisms involved and determining when after SCI receptor targeting is likely to be most effective.

PI_NAMEs: SCARISBRICK, ISOBEL A (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;Address;Appearance;Astrocytes;astrogliosis;Axon;Biological Assay;Biological Availability;Bone Marrow;Brain;brain health;cell injury;Cell Physiology;Cell Surface Receptors;Central Nervous System Diseases;central nervous system injury;Chimera organism;Chronic;Clinical;clinical translation;Coculture Techniques;combinatorial;Coupling;design;disability;Disease;Enzymes;Event;Exhibits;Experimental Designs;Experimental Models;experimental study;F2R gene;FDA approved;Fostering;functional improvement;G-Protein-Coupled Receptors;genetic approach;Growth Factor;Hormones;Immune;improved;improved outcome;In Vitro;Individual;Inflammation;Inflammatory Response;Injury;injury and repair;insight;Kininogenase;Knock-out;knockout gene;Knowledge;Laboratories;Link;Locomotor Recovery;loss of function;LoxP-flanked allele;MAP Kinase Gene;Messenger RNA;Microglia;Modeling;Molecular;monocyte;Mus;Myelin;Myelin Sheath;Myelinated nerve fiber;nerve injury;neural;neural repair;neurobehavioral;Neuroglia;neuroinflammation;Neurons;neuropathology;neuroprotection;Oral;Outcome;PAR-1 Receptor;Pathogenesis;Pathology;Pathway interactions;Peptide Hydrolases;Peripheral;pharmacologic;Physiological;Play;Positioning Attribute;Property;Proteinase-Activated Receptors;Publishing;receptor;Recovery;Recovery of Function;repair strategy;repaired;Research Design;response;response to injury;restoration;Ribosomes;Role;Sensorimotor functions;Serine Protease;Signal Transduction;small molecule inhibitor;Spinal cord injury;STAT3 gene;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;Thrombin;Thrombin Receptor;Time;tool;Translations;Treatment Efficacy;United States

PROJECT_TITLE: Targeting Protease Activated Receptor 1 for Repair of the Injured Spinal Cord

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ORG_CITY: ATLANTA

ORG_DEPT: NEUROLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Current treatments for the motor symptoms of Parkinson’s disease (PD) are effective but can have significant side effects that limit their usefulness. We propose a novel approach to treat PD, based on modulation of the activity of genetically specific neurons in the brain, rendering them susceptible to activation or inactivation by systemically administered drugs that are otherwise inert. We will study the use of this ‘chemogenetic’ approach in parkinsonian primates, with the long-term goal of developing an effective chemogenetic treatment for PD that has greater specificity and fewer side effects than existing therapies.

PI_NAMEs: GALVAN, ADRIANA  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine;Acetylcholine;Acute;Adverse effects;Affect;Affinity;alpha-bungarotoxin receptor;Animal Model;Animals;Anions;Autopsy;awake;Basal Ganglia;Behavioral;Binding;Brain;Brain region;Cell Nucleus;Chronic;Clinical;clinical practice;Corpus striatum structure;Data;Devices;Disabling;Dopamine;Dose;Electrons;Electrophysiology (science);expectation;experimental study;extracellular;FDA approved;Genetic;genetic approach;Genetic Techniques;Gliosis;Globus Pallidus;Glycine Receptors;Goals;Histologic;histological studies;human disease;Infection;Ion Channel Gating;Ions;Levodopa;Ligand Binding Domain;Ligands;Light;Long-Term Effects;Longevity;Macaca mulatta;Mediating;Methods;Microscopic;minimally invasive;Modeling;Monkeys;Motor;motor impairment;Motor Neurons;motor symptom;Movement;MPTP Poisoning;Mutate;National Institute of Neurological Disorders and Stroke;neuroinflammation;neuronal patterning;Neurons;neurosurgery;neurotoxic;nigrostriatal dopaminergic pathway;nonhuman primate;novel;novel strategies;Operative Surgical Procedures;Output;Parkinson Disease;Parkinsonian Disorders;parkinsonian non-human primate;Pathologic;Patients;Pattern;Penetration;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Physiological;Predisposition;Primates;receptor;receptor expression;response;side effect;smoking cessation;Specific qualifier value;Specificity;Surface;symptom treatment;System;Techniques;Testing;Therapeutic;Translations;treatment strategy;varenicline;Viral;Viral Vector;Work

PROJECT_TITLE: Chemogenetic Inactivation of the Primate Internal Globus Pallidus as a treatment for Parkinsonism


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Pediatric

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Mathematical learning disabilities (MLD) affect up to 14% of school-age children, leading to adverse life-long consequences for socio-economic well-being, health, and life expectancy. The proposed studies will use a theoretically motivated cognitive intervention, novel computational tools, and brain network models to provide important new knowledge about cognitive and brain mechanisms underlying remediation of poor numerical skills in children with MLD. Findings from our studies will identify the mechanisms by which cognitive intervention enhances foundational cognitive skills and learning in children with MLD and determine sources of individual differences in learning in RTI, with broad implications for optimizing learning in children with learning disabilities and neurodevelopmental disorders more broadly.

PI_NAMEs: MENON, VINOD  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Address;Affect;Architecture;Area;Arithmetic;Attention;Basal Ganglia;behavior measurement;Brain;Child;Cognitive;cognitive control;cognitive process;cognitive skill;Computer Models;computerized tools;design;disability impact;effective intervention;efficacy evaluation;Etiology;functional plasticity;Goals;Health;Health Resources;Impaired cognition;improved;Individual Differences;innovation;insight;Intervention;Knowledge;Learning;Learning Disabilities;Life Expectancy;Link;Maps;mathematics disability;medial temporal lobe;Memory;Modeling;Monitor;Morbidity - disease rate;network models;neural;neural correlate;Neurobiology;Neurocognitive;Neurodevelopmental Disorder;Neuronal Plasticity;Neurosciences;novel;novel strategies;Occipital lobe;Parietal;Parietal Lobe;Pathway Analysis;peer;Performance;Personal Satisfaction;poor health outcome;Prefrontal Cortex;Problem Solving;Process;Productivity;Public Health;randomized controlled design;remediation;Research;response;School-Age Population;skills;socioeconomics;Source;System;Visuospatial

PROJECT_TITLE: Interventions in math learning disabilities: cognitive and neural correlates

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_CITY: CHAMPAIGN

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Novel Diagnostic Tools and Animal Model System for Study Human/Animal Interface of COVID-19 Projective Narrative: This collaborative project between University of Illinois and Cornell University will develop novel reagents, assays, and animal model system for SARS-CoV-2 diagnostics, pathogenesis and epidemiology studies in pets and zoo animals. It addresses the urgent needs for understanding the distribution and natural history of SARS-CoV-2 viruses in animal populations at the human/animal interface, with particular emphasis on pets and zoo animal resource and reservoirs. The feline model system established in this study will reveal the pathogenic mechanisms of SARS-CoV-2 and provide an important tool for screening vaccine and therapeutic candidates.

PI_NAMEs: DIEL, DIEGO G;FANG, YING  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;ACE2;Address;animal care;Animal Experiments;Animal Model;animal resource;Animals;Antibodies;Area;Back;Biological Assay;Biological Models;Characteristics;China;Coronavirus;COVID-19;COVID-19 assay;COVID-19 detection;COVID-19 diagnostic;COVID-19 pandemic;COVID-19 surveillance;COVID-19 susceptibility;Data;design;detection assay;Development;Diagnostic;diagnostic assay;Diagnostic Reagent;diagnostic tool;Disease;Dose;Early Diagnosis;Enzyme-Linked Immunosorbent Assay;epidemiology study;Family;Family Felidae;Felis catus;Finding by Cause;General Population;Goals;Human;human disease;Illinois;Immune response;Immunize;Immunoglobulins;Immunology;improved;Individual;Infection;International;medical countermeasure;Modeling;Molecular;Monitor;Monoclonal Antibodies;Mutation;National Institute of Allergy and Infectious Disease;Natural History;novel;novel diagnostics;Oryctolagus cuniculus;Outcome Study;Panthera leo;pathogen;Pathogenesis;Pathogenicity;pet animal;polyclonal antibody;Population;Prevalence;Proteins;public health emergency;rapid detection;rapid test;Reagent;receptor;Research;Research Personnel;Risk;Risk Factors;Sampling;SARS coronavirus;SARS-CoV-2 exposure;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;Screening procedure;Serology test;Seroprevalences;serosurveillance;Serum;Source;Specimen;Strategic Planning;Study models;success;surveillance network;Surveillance Program;Testing;therapeutic candidate;Tigers;Time;tissue tropism;tool;transmission process;Universities;Vaccinated;vaccine candidate;Vaccinee;Vaccines;Validation;Veterinarians;Viral;Viral Pathogenesis;Viral Proteins;Viral reservoir;viral transmission;Viremia;Virus;Virus Diseases;Virus Receptors;Virus Shedding;World Health Organization;Zoo Animals

PROJECT_TITLE: Novel diagnostic tools and animal model system for study human/animal interface of COVID-19

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care;Telehealth

ORG_CITY: BLOOMINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE This randomized clinical trial tests how telehealth technology can positively affect informal caregivers and patients living with Alzheimer’s disease and related dementias. The project will gather data over time to measure the impact of our evidence-based Brain CareNotes mobile telehealth app on informal caregiver burden and patients’ behavioral and psychological symptoms of dementia, in a diverse Indiana-wide sample.

PI_NAMEs: BOUSTANI, MALAZ ;HOLDEN, RICHARD J (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: acute care;Affect;African American;Aggressive behavior;aging brain;Agitation;Alzheimer's Disease;Alzheimer's disease caregiver;Alzheimer's disease patient;Alzheimer's disease related dementia;attentional control;Behavior;Behavior Therapy;Behavioral Model;Behavioral Symptoms;Black race;Brain;brain based;Caregiver Burden;Caregivers;Caring;Clinic;Communities;Consent;cost;COVID-19;Data;Dementia;dementia care;depressive symptoms;Distress;Education;effectiveness research;Emergency department visit;Enrollment;Equipment and supply inventories;evidence base;Evidence based intervention;experience;feasibility trial;follow-up;Foundations;Funding;Goals;Health;health application;Health Technology;Hospitals;implementation research;Indiana;informal caregiver;informal support;innovation;Intervention;Intervention Studies;Long-Term Care;Marketing;Measures;Mental Depression;mobile application;mobile computing;Modeling;National Institute on Aging;neuropsychiatry;Nonpharmacologic Therapy;Pain;Patient Transfer;Patients;Pilot Projects;pilot trial;primary endpoint;primary outcome;programs;psychological symptom;Public Health;Publishing;Quality of life;Questionnaires;Race;Randomized;randomized, clinical trials;remote health care;remote intervention;remote technology;Sampling;Secure;Seminal;sex;Sleep disturbances;Source;Symptoms;systematic review;Technology;technology intervention;telehealth;Testing;therapy development;Time;United States National Institutes of Health;user centered design

PROJECT_TITLE: I-CARE 2 RCT: Mobile Telehealth to Reduce Alzheimer's-related Symptoms for Caregivers and Patients