ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Endocrine Disruptors;Maternal Health;Neurosciences;Nutrition;Pediatric;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Perfluorohexanoic acid (PFHxA) is a short-chain per- and polyfluoroalkyl substance (PFAS) whose presence has been reported in maternal serum and breast milk demonstrating that humans are exposed to PFHxA throughout brain development. While other PFAS that have been phased out of production, have been reported to suppress peripheral immune cells, the effects of PFHxA on the immune cells of the central nervous system, microglia, have not been investigated. This proposal will examine whether PFHxA exposure during gestation and lactation affects brain development and microglial function, providing evidence on the developmental neurotoxicity of this PFAS which is as of yet unregulated in the United States.

PI_NAMEs: PLUNK, ELIZABETH CATE (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Acids;Affect;angiogenesis;Animal Behavior;aqueous;Autopsy;Behavior;Behavioral Assay;Biodistribution;Brain;brain cell;Brain region;Breast Feeding;cell behavior;Cells;Central Nervous System;Cerebellum;chemical property;Child;cognitive function;consumer product;contaminated water;Data;Development;developmental neurotoxicity;Developmental Toxicant;differential expression;Environment;Epidemiology;epidemiology study;experimental study;exposed human population;Exposure to;Fetus;Film;Food;Furniture;Genes;Genetic;Health;Home;Human;Human Milk;Imaging Techniques;Immune;immune function;Immune response;Immunohistochemistry;immunosuppressed;in vivo two-photon imaging;Industrial Product;Infant;Ingestion;Injury;Lactation;Literature;Location;maternal serum;Microglia;Modeling;Morphology;Motor;Motor Activity;mouse model;Mus;Myelin;myelination;Nervous System;neural circuit;Neuroanatomy;neurodevelopment;Neuroglia;Neurons;neurotoxic;Neurotoxins;offspring;Pattern;Peripheral;Phase;Phenotype;Physiological;Placenta;Play;Poly-fluoroalkyl substances;Pregnancy;Production;protein expression;Proteins;Reporting;Research;Research Personnel;response;Role;Route;Serum;sex;Signal Pathway;Soil;Stains;substance use;Synapses;Testing;Time;Toxicant exposure;transcriptome sequencing;transcriptomics;two photon microscopy;United States;United States National Institutes of Health;vaccine immunogenicity;Water;Work

PROJECT_TITLE: NIH Plunk The Effects of Gestational and Lactational Exposure to Perfluorohexanoic Acid on Cerebellum Development in the Mouse


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Nutrition;Prevention

ORG_CITY: Newark

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Nonalcoholic steatohepatitis (NASH) is an increasingly common chronic condition that has harmful effects on the liver and is the leading indication for liver transplantation in the United States. There are no FDA approved drugs for NASH treatment, however, the Farnesoid X Receptor (FXR) has proven to be beneficial in the treatment of this metabolic disorder. The goal of this proposal is to understand underlying mechanisms contributing to the function of FXR in a tissue-specific manner for the development of novel, safe, and targeted therapeutics for the treatment of NASH.

PI_NAMEs: HENRY, ZAKIYAH RENEE (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Acute-Phase Proteins;Age;Agonist;Albumins;antagonist;Apoptotic;Bile Acid Biosynthesis Pathway;Bile Acids;Biochemistry;Biological Markers;Biological Process;Biomedical Research;blood glucose regulation;Cell Death;cell type;Cells;Cellular Membrane;Ceramides;Characteristics;Cholesterol;Cholesterol Homeostasis;Chronic;chronic liver disease;combat;cytotoxic;Data;Detergents;Development;Diet;dietary control;efficacious treatment;endoplasmic reticulum stress;Enterocytes;fast food;Fatty acid glycerol esters;fatty acid oxidation;Fatty Liver;FDA approved;Fellowship;Female;Fibrosis;G-Protein-Coupled Receptors;Gene Expression;Genotype;glucagon-like peptide 1;Goals;GPBAR1 gene;Health;Hepatic;Hepatocyte;Histologic;Homeostasis;Human;Immunohistochemistry;improved;Individual;Inflammation;Inflammatory;Intervention;Intestines;Knock-out;Knockout Mice;Life Style;Ligands;lipid biosynthesis;Lipids;Liver;liver inflammation;liver injury;liver transplantation;LoxP-flanked allele;male;Mediating;Metabolic Diseases;Mission;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutics;Organ;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;prevent;Prevention;Principal Investigator;Production;Property;protective effect;protein expression;Pruritus;Quality of life;receptor;Receptor Activation;receptor expression;Research;Role;Scientist;Serum;Side;side effect;simple steatosis;Small Intestines;Specificity;sugar;targeted treatment;Testing;Therapeutic;Tissue-Specific Gene Expression;Tissues;Training;transcription factor;transcriptome sequencing;United States;Up-Regulation;Ursodeoxycholic Acid;villin;Vision;Western Blotting;Work

PROJECT_TITLE: The Tissue-Specific Functionality of the Farnesoid X Receptor in NASH Development


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Women's Health Research

ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE Treatment of cancer is complicated by intratumor variation, in which individual cells and groups of cells within a single tumor respond differently to therapeutic agents. The high degree of intratumor heterogeneity in triple-negative breast cancers confounds treatment efforts. Here we develop a linked set of experiment-computational workflows to measure, track, and predict the behavior of heterogeneous triple-negative breast cancer cells.

PI_NAMEs: BROCK, AMY  (contact);YANKEELOV, THOMAS E

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Address;Bar Codes;behavior prediction;Big Data;Biological Specimen Banks;Breast Cancer Cell;Calibration;Cancer Biology;cancer therapy;Cell Count;cell dimension;cell growth;Cell Line;Cell Survival;Cells;Chemoresistance;chemotherapeutic agent;chemotherapy;Clinical;clinically relevant;Communities;cost;Data;Developmental Therapeutics Program;Diagnosis;Dimensions;Disease Progression;Doxorubicin;Drug resistance;epigenetic variation;Experimental Models;experimental study;Fluorouracil;Future;Gene Expression;Genomics;Goals;Growth;Heterogeneity;high dimensionality;Human;improved;Individual;individualized medicine;Link;Malignant Neoplasms;Maps;mathematical model;Measurement;Measures;medical schools;Methods;model development;Modeling;Molecular;multidimensional data;neoplastic cell;new technology;novel;Paclitaxel;Patients;Phenotype;Play;Population;Prediction of Response to Therapy;predictive modeling;Regimen;Resistance;response;Role;Sampling;Schedule;single-cell RNA sequencing;standard of care;System;Systems Biology;Technology;Testing;Texas;Therapeutic;Therapeutic Agents;therapy resistant;Time;transcriptome;transcriptomics;translational potential;Treatment Failure;treatment response;triple-negative invasive breast carcinoma;tumor;tumor heterogeneity;Universities;Variant

PROJECT_TITLE: Systems Approaches to Understanding Subpopulation Heterogeneity in Therapeutic Resistance


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: HUNTSVILLE

ORG_NAME: HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY

ORG_STATE: AL

PHR: Project Narrative Understanding the fundamental genetic changes associated with congenital disabilities and childhood cancers is an important step in developing tools for advanced prediction, treatment, and prevention of these devastating conditions. We propose to continue the collaboration of two world-class institutions in the continued development of a center to support researchers in their investigations of the genetics of congenital disabilities and childhood cancers. This resource will provide researchers with the tools necessary to advance our understanding of pediatric diseases and drive us closer to curing or preventing them.

PI_NAMEs: GRIMWOOD, JANE  (contact)

PROGRAM_OFFICER_NAME: FOURNIER, MARCIA VASCONCELLOS

PROJECT_TERMS: Address;Adult;Affect;Amaze;Biological Assay;Biology;cancer genome;Cancer Patient;Child;Childhood;Chromatin;Clinical;cohort;Collaborations;Collection;Communities;cost;Data;data access;Data Analyses;data integration;data resource;Data Storage and Retrieval;data submission;Death Rate;design;Development;disability;Disease;DNA sequencing;Emotional;Etiology;Event;exome;exome sequencing;experience;Experimental Designs;Family member;functional genomics;Funding;Gene Expression Profiling;Gene Fusion;Genetic;Genome;genome resource;genome sequencing;genome-wide;genome-wide analysis;genomic data;Genomics;Goals;Healthcare;improved;Individual;Infant Mortality;innovation;Institution;Investigation;leukemia;Malignant Childhood Neoplasm;Malignant Neoplasms;Methodology;Methods;Methylation;Molecular;Molecular Analysis;Molecular Conformation;Mutation;necrotic tissue;novel;Parents;Pathology;Pathway interactions;Pediatric Neoplasm;Pediatric Research;Physiological;prevent;Prevention;proband;Process;programs;public database;Renaissance;Reporting;Research;Research Personnel;Resolution;Resources;Saint Jude Children's Research Hospital;Sampling;single cell analysis;Societies;Source;success;Technology;therapeutic development;tool;transcriptome sequencing;tumor;tumor heterogeneity;United States National Institutes of Health;Variant;whole genome;Work

PROJECT_TITLE: Characterizing pediatric genomes through an optimized sequencing approach


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Physical Activity;Prevention;Sleep Research

ORG_CITY: BOSTON

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative Accurate measurement of physical activity, sedentary behavior, and sleep is necessary to support new science on behavior-related dose-response for major health conditions. We propose to develop novel methods to measure 24-hour physical behavior, as well as a procedure via which those methods can be compared to others. We aim to help the research community to converge on methods that use the devices to accurately measure physical activity type and intensity, sedentary behavior and posture, and sleep in adults.

PI_NAMEs: INTILLE, STEPHEN S (contact)

PROGRAM_OFFICER_NAME: WOLFF-HUGHES, DANA L

PROJECT_TERMS: Acceleration;Accelerometer;actigraphy;Adopted;Adult;Ankle;Behavior;Behavioral;biobank;Categories;Chronic Disease;Communities;Community Actions;Data;Development;Devices;Disease;Dose;Ecological momentary assessment;Ensure;epidemiology study;Feedback;fitness;Goals;Head;Health;Health behavior;Hour;Human;Imagery;improved;interest;Intervention;Intervention Studies;Knowledge;Label;Light;Location;Measurement;Measures;Methods;Modeling;Monitor;Motion;Movement;National Health and Nutrition Examination Survey;novel;novel strategies;Outcome Measure;Participant;Performance;Physical activity;Polysomnography;Posture;Procedures;Protocols documentation;Public Health;Publishing;Research;Research Personnel;response;Sampling Studies;Science;sedentary lifestyle;Sleep;Sleep Stages;surveillance study;Techniques;Time;tool;Uncertainty;Validation;Wrist;wrist worn device

PROJECT_TITLE: Accelerating the development of novel methods to measure 24-hr physical behavior

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative Transmembrane adhesion proteins are required for converting mechanical signals into cell activity. This research develops new computational methods based on all-atom simulations in order to quantify precisely how the molecular structure and function of integrin transmembrane proteins enables the conversion of mechanical signals into cell motion. Results will identify targets for treatments of diseases of mechanotransduction, including cardiovascular diseases, fibrosis of many organs and cancer, in which cells sense and transduce altered external mechanical forces. They will also provide the basis for future design of smart materials able to respond to mechanical signals in a controlled way.

PI_NAMEs: BIDONE, TAMARA  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Adhesions;Biochemical;Cardiovascular Diseases;Cell model;Cell Physiology;Cells;Computer Models;Computing Methodologies;design;Disease;Environment;extracellular;Fibrosis;Future;Grain;Human Pathology;Integral Membrane Protein;Integrins;Ligand Binding;Malignant Neoplasms;mechanical force;mechanical signal;Mechanics;mechanotransduction;Membrane;Methods;migration;Molecular;Molecular Conformation;molecular dynamics;Molecular Structure;Motion;multi-scale modeling;Organ;Pathway interactions;Play;Proteins;receptor;Research;response;Role;Signal Transduction;simulation;Techniques;Transport Process;Variant

PROJECT_TITLE: Computational models of cell mechanosensing through integrin-based adhesions


ADMINISTERING_IC: OD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dental, Oral, and Craniofacial Disease;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project narrative The mesolimbic dopamine system plays a crucial role in our ability to form close bonds with loved ones, and atypical activity of this circuitry is a common feature of several neuropsychiatric diseases that feature an onset during adolescent development. Social experiences play a crucial role in scaffolding brain development, but the ways in which changing adolescent reward circuits are shaped by early social interactions to facilitate adult bonding remains unknown. I will leverage the use of the socially monogamous prairie vole system to discover the activational, functional, and transcriptional features of dopaminergic reward circuit development, furthering our understanding of the pathophysiology of diseases that involve impaired social bonding behaviors.

PI_NAMEs: HIURA, LISA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Adolescence;Adolescent;Adolescent Development;Adult;Age;Agreement;Animal Technicians;Animals;Appointment;Attention deficit hyperactivity disorder;autism spectrum disorder;Automobile Driving;Award;Basic Science;Behavior;Behavior Control;Behavioral Paradigm;Brain;career;Cell Physiology;Cellular biology;Color;Colorado;Core Facility;data analysis pipeline;design;Development;Developmental Biology;Disease;Dopamine;dopamine system;Dryness;Embryonic Development;Ensure;experience;Faculty;Fellowship;Female;Fiber;forging;Foundations;Functional disorder;functional outcomes;Funding;Gene Expression Profile;Gene Expression Regulation;Genetic;genetic approach;Genetic Transcription;Goals;Grant;Growth;Health;Health Benefit;Home;HRK gene;human model;Imaging Techniques;Impairment;in vivo;Individual;innovation;insight;Institution;instrumentation;interest;Knowledge;Laboratories;Laboratory mice;Laboratory Rat;Life;loved ones;Major Depressive Disorder;mature animal;Mediating;Mentors;Mentorship;mesolimbic system;Microscopy;Microtus;Molecular;Molecular Biology;Motivation;neural;neural circuit;Neurodevelopmental Disorder;neuromechanism;Neurons;neuropsychiatric disorder;neuropsychiatry;neuroregulation;Neurosciences;novel;optogenetics;Pair Bond;Partner in relationship;Pathogenesis;Pathology;Pharmacogenetics;Phenotype;Photometry;Physiological;Play;Positioning Attribute;postnatal development;Poverty;prairie vole;Predisposition;Principal Investigator;Process;professor;programs;Property;protective effect;Publications;Rattus;Recording of previous events;Research;Research Assistant;Resources;reward circuitry;reward dysfunction;Rewards;Risk;Rodent;Rodent Model;Role;Same-sex;scaffold;Schizophrenia;Secure;sex;Shapes;Signal Transduction;social;social anxiety;social attachment;Social Behavior;social deficits;Social Development;social engagement;Social Interaction;Social isolation;Social Network;social neuroscience;social skills;Stem Cell Research;Support System;System;Technical Expertise;Technology;Therapeutic;therapeutic target;Time;Translational Research;Universities;Viral;Well in self;Work

PROJECT_TITLE: Functional ontogeny of pair bonding neural circuits

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)R]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Microbiome;Prevention

ORG_CITY: SEATTLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Dental caries is an enormous health problem worldwide and there is a shift towards oral microbial community dominated by cariogenic bacterium, eg: Streptococcus mutans, in caries-active subjects. Commensal bacteria normally help to control S. mutans via bioactive products such as H2O2; however, high-sugar consumption, which is frequently found in populations with high caries rates, could inhibit the generation of H2O2 through carbohydrate catabolite repression and disrupt the homeostasis. This project will investigate if selective photoactivated semiconducting metal titanates will produce extrinsic H2O2 from O2 reduction and other reactive oxygen species (ROS), to inhibit S. mutans, while giving an advantage to commensal bacteria and thereby maintain homeostasis in dental biofilms and thus prevent dental caries.

PI_NAMEs: HUANG, XUELIAN  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acids;Anti-Bacterial Agents;anticaries;Award;Bacteria;biofilm species;Carbohydrates;career development;Caries prevention;cariogenic bacteria;catalyst;Cells;Ceramics;Chemistry;Clinical;commensal bacteria;Complex;Composite Resins;Consumption;Dental;dental adhesive;dental biofilm;Dental caries;Dental Materials;Development;Development Plans;Ecology;Esthetics;Gene Expression;Gene Expression Profile;Generations;Genes;Gold;Health;Homeostasis;Hydrogen Peroxide;improved;In Situ;Measures;Mentorship;Metal exposure;Metals;Microbial Biofilms;microbial community;Microbiology;Molecular;Monitor;Mouth Diseases;mRNA sequencing;multidisciplinary;mutant;novel;oral biofilm;Oral cavity;oral commensal;oral microbial community;oral microbiome;oxidation;Oxidative Stress;pathogen;Performance;Photochemistry;physical property;Population;Positioning Attribute;practical application;prevent;Prevention strategy;Process;Production;Reaction;Reactive Oxygen Species;real time monitoring;Repression;Research;Research Personnel;Research Project Grants;response;Streptococcus gordonii;Streptococcus mutans;Streptococcus sanguis;Stress;Structure;sugar;System;Testing;Therapeutic;Toxic effect;Virulence;Visible Radiation;Work

PROJECT_TITLE: Metal-titanates, novel anti-caries catalysts for modulating the virulence of cariogenic biofilms

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE A striking characteristic of bilingual speakers is code-switching (alternating two languages within a single discourse) to meet pragmatic and/or linguistic needs. Prior research has explored the grammatical constraints and sociolinguistic aspects of code-switching independently. However, few have examined how these constrain may interact to influence differences in code-switch patterns between children with and without developmental language disorder. Therefore, the proposed research will investigate the sociolinguistic characteristics (interlocutors, language proficiency and language ability) among bilingual children with and without language disorder. The objective is to enhance the theoretical foundation and gain deeper insights into the code switching behaviors of bilingual children as they learn to navigate between two languages.

PI_NAMEs: HERNANDEZ, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TITLE: The Role of Interlocutor Behavior on Code Switching Patterns in Bilingual Children with and without Developmental Language Disorders


ADMINISTERING_IC: MH

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Epilepsy;Mental Health;Neurodegenerative;Neurosciences;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: San Diego

ORG_NAME: QUASAR, INC.

ORG_STATE: CA

PHR: Narrative Seizures are a common neurological disorder in infants occurring in some 14,000 newborns annually in the US. Early detection and treatment can result in more effective seizure control and lower rates of morbidity and mortality. Quantum Applied Science and Research (QUASAR), in collaboration with Children’s National Hospital (CNH), propose to develop an innovative Neonatal EEG MOnitor (“NEMO”) system intended as a reliable and easy-to-use EEG system that will increase availability of neonatal EEG monitoring at all hours of the day and to hospitals that typically lack this capability. This advance will lead to more neonates at risk for seizures being quickly screened and appropriately treated, which in turn is expected to shorten hospital stays and improve outcomes.

PI_NAMEs: MCDONALD, NEIL J (contact);TSUCHIDA, TAMMY

PROGRAM_OFFICER_NAME: DURKIN, JACLYN MARIE

PROJECT_TERMS: Adult;Applied Research;biomaterial compatibility;Businesses;Child;Clinical;Collaborations;commercial launch;commercialization;Data;design;Development;Devices;Documentation;Dryness;Early Diagnosis;Early treatment;Electrodes;Electroencephalography;Electromagnetics;Electronics;Environment;Epilepsy;Evaluation;Feedback;follow-up;Funding;Gel;Goals;Good Manufacturing Process;Hospitals;Hour;Human;Hygiene;improved outcome;Infant;innovation;Intellectual functioning disability;Length of Stay;manufacturability;manufacture;Manufacturer;Marketing;Medical;Medical Device;Monitor;monitoring device;Morbidity - disease rate;mortality;Neonatal;Neonatal Intensive Care Units;neonatal seizure;neonate;Nervous System Disorder;Neurodevelopmental Disability;Newborn Infant;pandemic disease;Pediatric Hospitals;Performance;Personal Satisfaction;Phase;Positioning Attribute;pressure;Protocols documentation;prototype;quantum;Risk;Safety;safety testing;Seizures;sensor;sensor technology;Signal Transduction;skills;Skin;skin damage;Skin injury;Small Business Innovation Research Grant;Specific qualifier value;System;Testing;Time;United States National Institutes of Health;usability;Validation;Work

PROJECT_TITLE: Neonatal EEG MOnitor (NEMO) Phase IIb

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-S(11)B]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Radiation Oncology;Urologic Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Bladder removal surgery (radical cystectomy) and bladder-sparing chemoradiotherapy (CRT) are the two curative treatment approaches for muscle-invasive bladder cancer supported by long-term safety and efficacy data, but no molecular biomarkers are currently available to inform the choice between these approaches. We have identified a subset of ~15% of MIBCs with somatic alterations in the nucleotide excision repair (NER) gene ERCC2, and we have shown that clinically observed ERCC2 mutations are unable to perform cellular NER and are sufficient to confer cisplatin sensitivity in MIBC preclinical models. We will define the impact of NER deficiency induced by ERCC2 mutations on bladder tumor properties and on response to clinically relevant bladder-sparing CRT regimens by integrating genomic and clinical data from clinical MIBC cohorts with functional data from novel NER-proficient and NER-deficient preclinical models.

PI_NAMEs: MOUW, KENT W (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Biological;Biological Assay;Biological Markers;Bladder;Bladder Neoplasm;cancer cell;cancer diagnosis;Cancer Model;Cancer Patient;CD8-Positive T-Lymphocytes;Cells;CHEK1 gene;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Cisplatin;Clinical;Clinical Data;Clinical Trials;clinically relevant;cohort;common treatment;curative treatments;Cystectomy;Data;Disease;DNA Adducts;DNA Damage;DNA lesion;DNA Repair Disorder;DNA Repair Pathway;ERCC2 gene;Excision;Functional disorder;Gene Expression Profile;Gene Expression Profiling;Gene Mutation;gene repair;Genes;Genome Stability;genomic data;Genomics;Goals;helicase;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;improved;improved outcome;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Mismatch Repair Deficiency;Missense Mutation;Modeling;molecular marker;Mus;muscle invasive bladder cancer;Mutagens;mutant;Mutant Strains Mice;Mutation;mutational status;Neoadjuvant Therapy;novel;novel strategies;Nucleotide Excision Repair;Nucleotide Excision Repair Inhibition;Organ Preservation;Outcome;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Platinum;Play;pre-clinical;Pre-Clinical Model;preference;preservation;prevent;Property;Provider;Quality of life;Radical Cystectomy;randomized trial;Regimen;repair function;repaired;response;Role;Safety;Shapes;Solid Neoplasm;Specimen;T-Cell Activation;Testing;Therapeutic;therapeutic target;treatment response;trial comparing;tumor;tumor DNA;tumor microenvironment;tumor-immune system interactions;ultraviolet irradiation;Work

PROJECT_TITLE: Targeting Nucleotide Excision Repair Deficiency to Improve Bladder Sparing Treatment for Muscle Invasive Bladder Cancer


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CHICAGO

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE: Interhospital transfer, the process of a patient being moved from one hospital to another for advanced and/or specialized care or patient preference, is occurring more frequently but the current process has many problems. These include poor communication between the doctors, poor communication between doctors and the patient and family, and inconsistent clinical practices. We will use methods from engineering and design to understand the reasons for these problems, get help from doctors, nurses, paramedics, patients, and families to create solutions, and test those solutions in two hospitals.

PI_NAMEs: PRUITT, PETER B (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Improving Interhospital Transfer of Patients with Neurologic Emergencies

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Spinal Muscular Atrophy

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Mounting evidence correlates the dysregulation of spatial mRNA organization to an increasing number of diseases, including amyotrophic lateral sclerosis (ALS), fragile X syndrome (FXS), and spinal muscular atrophy (SMA). However, the regulatory mechanism and pathological consequences of spatial RNA organization have only been explored for a limited fraction of mRNAs, due to a lack of technologies that allow for tracking and manipulating the subcellular localization of endogenous mRNAs. We develop a transformative framework including several technologies: single-molecule, real-time RNA monitoring (RNA-LiveFISH), manipulation of any endogenous mRNA(s) for spatial localization on a large scale (CRISPR-TO), and related machine learning algorithms, and we will apply the framework to gain new insights into the functional roles of spatial RNA organization in axon development and guidance in primary neurons and explore the approach of modulating mRNA localization as a therapeutic strategy to treat spinal muscular atrophy.

PI_NAMEs: QI, LEI STANLEY (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Amyotrophic Lateral Sclerosis;Atlases;Axon;axon guidance;Biology;Cell Physiology;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Computer Analysis;deep learning;Development;Disease;Embryo;Fluorescent in Situ Hybridization;Foundations;Fragile X Syndrome;Goals;Image;In Situ;In Vitro;in vivo;insight;machine learning algorithm;Mediating;Messenger RNA;Methods;Monitor;Nervous System Disorder;Neurons;novel strategies;Pathologic;Pathology;Physiological;Play;Protein Biosynthesis;Regulation;Resolution;RNA;RNA-Binding Proteins;Role;single molecule;Site;spatiotemporal;Spinal Muscular Atrophy;Synapses;Technology;Therapeutic;Time;Transcript;transcriptomics;Untranslated RNA

PROJECT_TITLE: Manipulating and Interrogating Spatial Transcriptomics


ORG_CITY: Aurora

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Narrative  We are proposing to develop an axon-specific bidirectional optical neural interface and test the system's efficacy to neuromodulate the parasympathetic nervous system by modulating heart function. We will use optogenetics and multiphoton optical excitation to simultaneously detect the neural activity and photostimulate individual axons from the exterior of the nerve i.e. an approach that is non-invasive yet has specificity. This technology has potential for major impact on the ability to treat many conditions; for example, vagal nerve stimulation in humans has been found to control epilepsy and depression, and evidence points to improvements in treatment of inflammatory bowel disease and Alzheimer's Disease.

PI_NAMEs: CALDWELL, JOHN H;GIBSON, EMILY ;WEIR, RICHARD FERGUS FFRENCH (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: 3-Dimensional;Abdomen;Action Potentials;Afferent Neurons;Alzheimer's Disease;Anesthesia procedures;Animals;awake;Axon;Behavior;Behavioral;Biomedical Research;Brain;Breathing;Calcium;calcium indicator;Cardiac;Cardiology;Cells;Cervical;Chest;Chronic;Clinical;clinical application;Collaborations;Communication;conditioned fear;Development;Devices;disability;Disease;Efferent Neurons;Electrocardiogram;Electrodes;Engineering;Epilepsy;Fascicle;FDA approved;flexibility;Future;Generations;Genetic Vectors;Glass;Goals;Grant;Heart;heart function;heart imaging;Heart Rate;Human;human disease;Image;Implant;implantation;improved;in vivo;Individual;Inflammatory Bowel Diseases;Injections;innovation;Lasers;lens;Lung;Measurement;Mechanics;Mental Depression;Metabolic Diseases;Methods;Microscope;Miniaturization;miniaturize;minimally invasive;Monitor;mouse model;multi-photon;multiphoton microscopy;Mus;Needles;Nerve;Nerve Tissue;neural;Neurons;neuroregulation;Neurosciences;new technology;novel;Opsin;Optic Nerve;Optics;optogenetics;Organ;Parasympathetic Nervous System;Pathway interactions;Penetration;Peripheral;Peripheral Nerves;Peripheral Nervous System;pharmacologic;Pharmacologic Substance;Physiologic pulse;Physiological;Polymers;portability;Property;Proteins;prototype;Publications;Reporter;Research;Research Personnel;Resolution;Scanning;side effect;Signal Transduction;Source;Specificity;stressor;System;Systems Integration;Tail;Techniques;Technology;Testing;Transgenic Mice;translation to humans;translational potential;two-photon;United States National Institutes of Health;Vagus nerve structure;Veins;Viral;Viral Vector;virtual;Virus;voltage;Work

PROJECT_TITLE: Optimization of a Minimally-Invasive Bidirectional Optogenetic Peripheral Nerve Interface with Single Axon Read-in & Read-out Specificity

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Serious Mental Illness;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE/RELEVANCE This research plan addresses one of the most critical issues at the interface of the mental health and criminal justice systems for individuals living with serious mental illnesses (SMI): how to implement evidence-based practices within a complex environment in order to improve outcomes for adults with SMI. This project adapts and tests an implementation strategy to improve collaboration and coordination between specialty mental health probation officers and mental heath service providers to increase linkage to treatment. In the long-term, this research will improve fidelity of the specialty metal health probation model, define best practice standards for addressing SMI among individuals on probation, and address Goal 4, Objective 4.3 of the NIMH Strategic Plan to enhance the reach of mental health services to underserved populations (e.g., individuals in the criminal justice system).

PI_NAMEs: VAN DEINSE, TONYA BLOOMER (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Address;Adult;Award;Awareness;Cluster randomized trial;Collaborations;Complex;Coordination and Collaboration;cost;County;Criminal Justice;Data;Development;Education;effectiveness outcome;efficacy evaluation;Environment;Evidence based practice;experience;Exploration, Preparation, Implementation, and Sustainment;Foundations;Funding;Goals;Graph;Health Personnel;Health Services Accessibility;Health system;Hybrids;implementation context;implementation cost;implementation intervention;implementation outcomes;implementation strategy;improved;improved outcome;Individual;Interdisciplinary Study;Intervention;Interview;Jail;Justice;Knowledge;Learning;Link;Manuscripts;Measurement;medical specialties;member;Mental Health;Mental Health Services;Mentors;Methodology;Methods;Modeling;multilevel analysis;National Institute of Mental Health;Outcome;parole;Pathway Analysis;Perception;Persons;Phase;Policies;Private Sector;probation;probationer;Procedures;process evaluation;programs;Protocols documentation;rearrest;Research;Research Activity;Research Design;Research Proposals;research study;Resources;Science;service engagement;service providers;severe mental illness;Social Network;Specific qualifier value;Statistical Methods;Strategic Planning;Structure;substance use;Supervision;Symptoms;System;Taxonomy;Testing;tool;Training;Underserved Population;United States National Institutes of Health

PROJECT_TITLE: Enhancing Mental Health Treatment Engagement among Probationers: Adapting an Organizational Linkage Implementation Strategy for Specialty Mental Health Probation

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Genetics;Nutrition;Obesity;Prevention

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE. Approximately 42%of American adults are obese, and this condition is strongly related to the development of colorectal cancer. Innovative lifestyle strategies to treat obesity and reduce colorectal cancer risk are critically needed. The proposed research will demonstrate that time-restricted eating, a type of intermittent fasting, is an effective therapy to help obese individuals reduce and control their body weight and prevent the development of colorectal cancer.

PI_NAMEs: TUSSING-HUMPHREYS, LISA  (contact);VARADY, KRISTA AMY

PROGRAM_OFFICER_NAME: EMENAKER, NANCY J

PROJECT_TERMS: Address;Adenomatous Polyps;Adherence;Adult;adult obesity;Affect;American;Animals;anti-cancer;Apoptosis;arm;Behavioral Sciences;Biological;Biological Markers;Biometry;Blood;Blood Pressure;Body Composition;Body fat;Body mass index;Body Weight;Body Weight decreased;Caloric Restriction;Calories;cancer biomarkers;Cancer Etiology;cell growth;Cessation of life;Chronic Disease;circulating biomarkers;Clinical;Clinical Research;Clinical Trials;Colon;colon carcinogenesis;colon tumorigenesis;Colorectal Cancer;colorectal cancer risk;common treatment;Consumption;cytokine;Data;Development;Diagnosis;dieting;Differentiation Antigens;Disease;DNA Damage;Eating;effective therapy;Environmental Exposure;Epigenetic Process;experience;feasibility testing;Food;Gastroenterology;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene repression;Genetic;glucose metabolism;Health;Heredity;Hour;human old age (65+);Immune;Immune System Diseases;improved;Incidence;Individual;Inflammation;Inflammatory;inflammatory marker;innovation;Insulin Resistance;Insulin-Like Growth Factor I;Interleukin-6;Intermittent fasting;Intervention;Isoprostanes;Life Style;lifestyle intervention;Link;Maintenance;Malignant Neoplasms;Mediating;Metabolic;Metabolic dysfunction;Methods;modifiable lifestyle factors;modifiable risk;Molecular;molecular marker;Monitor;Mucositis;Mucous Membrane;muscle form;Mutation;National Cancer Institute;novel;Nutritional Science;obese person;Obesity;obesity treatment;Oxidative Stress;Pathway interactions;Persons;Phase;Pilot Projects;Population;prevent;Process;Proliferating;protective effect;Randomized;reduced food intake;Research;Risk;Risk Factors;Risk Marker;Risk Reduction;Safety;Specific qualifier value;systemic inflammatory response;Testing;Thinness;Time;Time-restricted feeding;Tissues;tool;United States;Up-Regulation;Water;Weight;Weight maintenance regimen

PROJECT_TITLE: Effects of Time-restricted Eating versus Daily Continuous Calorie Restriction on Body Weight and Colorectal Cancer Risk Markers among Adults with Obesity


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Wound Healing and Care

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE While wound healing by regeneration is highly desirable, skin wounds in adult mice and humans most commonly repair by fibrotic scarring. We discovered that when wounds in mice are treated with immune-modulating biomaterials, they heal by regenerating new hair follicles. Here, we propose a series of bioengineering and animal studies to test the hypothesis that immune triggers within biomaterials can shift interactions between wound immune cells and fibroblasts from fibrotic toward a highly desirable regenerative response.

PI_NAMEs: SCUMPIA, PHILIP  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: adaptive immune response;adaptive immunity;Adipocytes;Adipose tissue;Adult;Animals;Antigens;Back;Biocompatible Materials;Bioinformatics;Biology;Biomedical Engineering;Cells;Cicatrix;Clinical;crosslink;Data;Deposition;design;Development;Elements;Embryo;enantiomer;Engineering;Extracellular Matrix;Fibroblasts;Fibrosis;Flow Cytometry;Foreign Bodies;Foreign-Body Reaction;Formulation;functional gain;Future;gain of function;Gel;Gene Expression;gene regulatory network;Genetic;Grant;Growth;Growth Factor;Hair;Hair follicle structure;hair regeneration;healing;Histology;Human;Hydrogels;Immune;Immune signaling;Immunology;immunoregulation;improved;in vitro Assay;in vivo;in vivo Model;Inflammatory Response;innovation;Integrin Binding;Interleukins;Knowledge;Ligands;loss of function;Lymphocyte;Macrophage;Mammals;Mesenchymal;Molecular;Mus;Natural regeneration;network models;next generation;non-genetic;novel;novel strategies;Outcome;overexpression;particle;Pathway interactions;Peptides;phenotypic biomarker;Population;Porosity;Prevention;Profibrotic signal;Property;Proteomics;Publications;Receptor Gene;regenerative;regenerative approach;regenerative healing;Regenerative response;Regenerative wound healing;repaired;Research;Resolution;response;Role;Science;Series;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;skin regeneration;skin wound;small molecule inhibitor;Speed;stem cells;Sweat Glands;T-Lymphocyte;Testing;tissue repair;Tissues;transcriptomics;Transgenic Mice;Translating;wound;wound closure;wound healing;Wound models;wound treatment

PROJECT_TITLE: Leveraging immune-fibroblast interactions for biomaterial induced skin regeneration

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PROJECT NARRATIVE This research is expected to increase our understanding of the role of sensory feedback on the recovery of movements post-stroke. The proposed work is likely to provide a new way to assess movement dysfunction from the sensory perspective, especially in more impaired individuals who have difficulty performing movement tasks. Findings of the proposed research may permit the future development of targeted interventions, from a novel sensory or sensory-motor perspective, to combat post-stroke movement impairments.

PI_NAMEs: YANG, YUAN  (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Acute;arm;arm paresis;Bilateral;Brain;Brain imaging;Brain Injuries;Chronic;combat;Contralateral;Data;density;Development;Diffusion Magnetic Resonance Imaging;Dyskinetic syndrome;Electroencephalography;Experimental Designs;Fingers;Foundations;Functional disorder;Future;Generations;Goals;Hand;Hand functions;hemiparetic stroke;Hyperactivity;imaging approach;Impairment;improved;indexing;Individual;Intervention;Knowledge;Lesion;Limb structure;Link;Maps;Methods;Motor;Motor Activity;motor control;motor deficit;motor impairment;Motor output;Motor Pathways;Movement;multimodality;Muscle;Neuronal Plasticity;novel;Paresis;Participant;Pathway interactions;Patients;Pattern;post stroke;prevent;Process;Protocols documentation;Ramp;Recovery;recruit;rehabilitation strategy;Reporting;Research;Response Latencies;Rest;Role;Sensory;sensory cortex;sensory feedback;sensory input;Severities;Shoulder;Signal Transduction;somatosensory;spasticity;stretch reflex;Stroke;synergism;System;Tactile;tactile stimulation;Testing;Therapeutic;Therapeutic Intervention;Torque;Upper Extremity;Work

PROJECT_TITLE: Shift from Unilateral to Bilateral Sensory-Motor Connectivity in Chronic Hemiparetic Stroke

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ORG_CITY: TSAILE

ORG_NAME: DINE' COLLEGE

ORG_STATE: AZ

PHR: NARRATIVE The Navajo NARCH Partnership will sustain and expand institutional partnerships designed to increase public health and health research educational and practice opportunities on the Navajo Nation. The Navajo NARCH is guided by stakeholders serving the Nation, specifically leaders in Western and Navajo health care, public health, education, and tribal government, who are acutely familiar with local challenges and successes in health and education systems and policies. The Center goal is to inspire and mentor a cadre of Indigenous scholars and health research professionals equipped to approach advance healthy equity in both Navajo Nation and Indian Country.

PI_NAMEs: BAUER, MARK C (contact);TEUFEL-SHONE, NICOLETTE I

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Achievement;Active Learning;Acute;Address;Agreement;Area;Arizona;Award;Child;Chronic;Claw;college;Colorado;Communities;community advisory board;Country;Course Content;design;Development;Diné Nation;Doctor of Philosophy;Education;education research;Environment;Equity;Exercise;experience;Exposure to;Fostering;Generations;Genetic;Genetic Research;Goals;Growth;Health;health equity;Health Policy;Health Professional;Healthcare;high school;Housing;Indigenous;innovation;Institution;Knowledge;Language;Language Delays;Laws;Lead;Leadership;Medical center;Mentors;Native American Research Center for Health;Native Americans;Navajo;Pathway interactions;Persons;Pilot Projects;Policies;programs;Public Health;recruit;Research;Research Personnel;Research Project Grants;role model;Scholarship;Scientist;Self Determination;Services;skills;social culture;solidarity;Standardization;Students;success;System;Testing;Training;Translating;tribal college;tribal Nation;Tribes;United States Indian Health Service;Universities

PROJECT_TITLE: Navajo NARCH Partnership

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y(55)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research

PHR: NARRATIVE  The Administrative Core of the Navajo NARCH Partnership will manage and leverage resources to build the  public health education, service and research capacity of the Navajo Nation, and to support career  development in health research and public health. Collaborative infrastructure, leadership and oversight will  support transparent communication and promote an environment conducive to ethical and productive training,  and innovative, culturally relevant research.

PI_NAMEs: BAUER, MARK C (contact)

PROJECT_TERMS: Achievement;Arizona;Award;career;career development;Collaborations;college;Communication;community advisory board;Decision Making;design;Development;Diné Nation;Dissemination and Implementation;Doctor of Philosophy;Education;education research;Ensure;Environment;Equity;Ethics;Evaluation;experience;Feedback;Fostering;Funding;Generations;Goals;Government;Health;Human Resources;Infrastructure;innovation;Institution;intergenerational;Knowledge;Leadership;meetings;member;Mentors;Methods;Modeling;Native American Research Center for Health;Navajo;operation;Outcome;Positioning Attribute;Primary Health Care;Productivity;programs;Progress Reports;Public Health;Public Health Education;Research;Research Personnel;Resource Allocation;Resources;Role;Running;Services;skills;Teleconferences;Training;tribal college;Tribes;Universities;verbal;Work;Writing

PROJECT_TITLE: Navajo NARCH Partnership Admin-Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

PHR: Project Narrative The overarching hypothesis of this Project is that reciprocal signaling between tumor cells and CAFs shapes malignant cell and CAF phenotypes that affect tumor progression and therapy responses. Identifying and characterizing these interactions will provide new insights into this biology and identify new approaches to target PDAC.

PI_NAMEs: AGUIRRE, ANDREW JAMES;DOUGAN, STEPHANIE ;HAHN, WILLIAM C. (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Adjuvant Study;Affect;Aftercare;Antibodies;Archives;biobank;Biology;Biopsy;cancer cell;Cell Communication;cell type;Cells;Cellular Structures;chemotherapy;Clinical;Clinical Trials;Coculture Techniques;Complex;cytokine;Data;Dermal;differential expression;digital;Disease Progression;Disease Resistance;Evolution;Exhibits;Fibroblasts;functional genomics;Gene Expression;Genetic Screening;Genetically Engineered Mouse;Genomic approach;Growth Factor;Heterogeneity;Human;Hypoxia;Immunofluorescence Immunologic;Impairment;innovation;insight;Investigation;Isogenic transplantation;Ligands;Liver;Malignant neoplasm of pancreas;Malignant Neoplasms;member;Mesenchymal;Metastatic Neoplasm to the Liver;Modeling;multidisciplinary;Nature;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;novel therapeutic intervention;Nutrient;Organ;Organoids;Pancreatic Ductal Adenocarcinoma;Patients;Pattern;Pericytes;Pharmaceutical Preparations;Phenotype;Play;Population;Prior Therapy;Process;programs;Protein Secretion;Resistance;response;Role;Sampling;Shapes;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Specimen;standard of care;Stromal Cells;Testing;TGFB1 gene;Therapeutic;therapeutic target;therapy resistant;transcriptome;translational scientist;transplant model;treatment response;tumor;tumor microenvironment;tumor progression;Tumor Subtype;tumor-immune system interactions;Work

PROJECT_TITLE: Stromal modulation of pancreatic cancer malignant cell state and therapeutic sensitivity


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Dental, Oral, and Craniofacial Disease;Gene Therapy;Genetics;Immunotherapy;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Alzheimer's disease is a neurodegenerative disorder that affects an approximate 6.2 million Americans and results in more than 120,000 death per year in the United States alone. In four years, the incidence is expected to increase by 22% and by 2050 its will nearly double. The pathology is hypothesized to initiated by abnormal deposition of beta-amyloid (A13) and progresses with the abnormal phosphorylation and deposition of tau. Despite its economic and societal impact, no drug has been able to prevent or halt progression of the disease. In this study, we will identify novel treatment approaches that have the potential to provide lasting Al3 clearance and prevention of Al3 deposition.

PI_NAMEs: GRAJALES-REYES, GARY E. (contact)

PROJECT_TERMS: abeta deposition;Accounting;Aducanumab;Affect;Age;aged;Alzheimer's Disease;American;Amyloid beta-Protein;Antibodies;Astrocytes;Binding;Bone Marrow;Bone Marrow Cells;Brain;candidate identification;career;catalyst;Cause of Death;CD8B1 gene;Cell Line;Cell Therapy;Cells;Central Nervous System Diseases;Cessation of life;chimeric antigen receptor;Chimeric Proteins;Clinical;Clinical Trials;Confocal Microscopy;cost;cost effective;cost estimate;Data;Dedications;Dementia;Deposition;design;Disease;Disease Progression;Economic Burden;Economics;effective therapy;experience;FDA approved;Flow Cytometry;Frequencies;Funding;Genetic;Genomic medicine;Gliosis;Goals;Hippocampus;Human;hyperphosphorylated tau;Immunology;in vivo;Incidence;Infection;Institution;Intervention;Knowledge;Label;Laboratories;Leadership;Light;live cell imaging;Membrane;Mentors;Microglia;Mus;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimmunology;neuron loss;Neurosciences;novel;novel strategies;Outcome;Pathologic;Pathology;Patients;Phagocytes;Phagocytosis;Pharmaceutical Preparations;Phase;Phosphorylation;Physiology;Postdoctoral Fellow;postnatal;prevent;Prevention;Primary Prevention;professor;programs;protein aggregation;receptor binding;Recombinants;Research;Research Personnel;Research Project Grants;Risk Factors;Scientist;stem cells;Symptoms;tau Proteins;Technology;tertiary prevention;Testing;therapy development;Time;Training;treatment duration;treatment strategy;United States;United States Food and Drug Administration;Vision;Work

PROJECT_TITLE: CAR-based approaches for the treatment of Alzheimer's Disease


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Pediatric;Racial and Ethnic Minority Health Research

PHR: NARRATIVE The Student Enhancement Project of the Navajo NARCH Partnership will build and sustain an education to profession pathway that applies the strengths and addresses needs for culturally relevant, research informed public health and health services within the Navajo Nation. Courses and webinars that use culturally-relevant frameworks and methods, service learning activities that provide practical experience and reinforce networks, and an internal system of mentorship will engage high school, undergraduate, and graduate students, and early career investigators to build skills and develop innovative strategies to advance health equity for the Navajo people.

PROJECT_TERMS: 3-Dimensional;Academic skills;Active Learning;Address;Agreement;Applications Grants;Arizona;Award;career;Career Choice;certificate program;Collaborations;college;Communication;Communities;community partners;Development;digital;Diné Nation;Disparity;Education;education pathway;Educational process of instructing;Educational workshop;Enrollment;Evaluation;evidence base;Exercise;experience;Faculty;Feedback;Funding;Generations;Goals;graduate school;graduate student;Grant;Health;Health Alliance;health equity;Health Personnel;Health Professional;Health Services;high school;High School Student;Hour;improved;Indigenous;Infrastructure;innovation;Institution;Institutionalization;instructor;Internships;Investments;Knowledge;Learning;Learning Skill;learning strategy;Mentors;Mentorship;Methods;Native American Research Center for Health;Navajo;Occupations;Outcome;Pathway interactions;peer coaching;Persons;Population;Postdoctoral Fellow;programs;promote resilience;Public Health;Public Health Schools;Public Health Students;recruit;Research;Research Personnel;Research Project Grants;Reservations;Resources;Role;Rural;Science;service learning;Site;skills;social;Structure;Students;success;summer research;Support System;System;Time;Training;Training and Education;training opportunity;Training Programs;tutoring;undergraduate student;United States Indian Health Service;United States National Institutes of Health;United States Public Health Service;Universities;university student;virtual;Voice;webinar;Work;Writing;Youth

PROJECT_TITLE: Student Career Enhancement Project


ADMINISTERING_IC: HL

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: AUGUSTA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Approximately 19 million deaths were attributed to cardiovascular disease (CVD) globally in 2020, an increase of ~20% from 2010, and heart disease remains the leading cause of death for men and women in the US. Hypertension is a major modifiable risk factor for CVD, and it has been suggested that eliminating hypertension could reduce CVD mortality 30.4% in men and 38.0% in women. This proposal will increase our understanding of how blood pressure increases in females and increase awareness of the risks associated with hypertension and cardiovascular disease.

PI_NAMEs: SULLIVAN, JENNIFER C (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Academy;Address;Adult;Age;American Heart Association;Awareness;biological sex;biomedical scientist;Black Populations;black women;blood pressure control;blood pressure elevation;Blood Pressure Monitors;burden of illness;Cardiovascular Diseases;cardiovascular disorder education;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;career;Cause of Death;Cessation of life;Clinical;college;Communities;community empowerment;community engagement;Community Outreach;design;Development;Disease;Disproportionately impacts women;doctoral student;Education;Educational Curriculum;Educational Materials;Educational workshop;elementary school;empowerment;Ensure;Equipment;Experimental Designs;experimental study;Faculty;Female;Funding;Goals;Guidelines;health care availability;Healthcare;Healthcare Systems;healthspan;Heart Diseases;high risk;Historically Black Colleges and Universities;Hypertension;Improve Access;improved;innovation;insight;interest;Learning;Location;male;Medical;medical schools;Medical Students;member;men;Mentors;modifiable risk;Monitor;mortality;mortality risk;next generation;novel;Obesity;Outcome;Patients;Pharmaceutical Preparations;Physicians;Pilot Projects;Population;Populations at Risk;Postdoctoral Fellow;pre-clinical;pre-doctoral;premature;Prevalence;Recommendation;Relative Risks;Research;Research Personnel;Research Support;Research Training;Risk;Rural;sabbatical;Schools;Science;Scientist;sex;sex as a biological variable;Sex Differences;Southeastern United States;Students;teacher;Techniques;Training;Trust;undergraduate student;Universities;Woman;Women's mortality;Work;young woman

PROJECT_TITLE: Improving awareness of women with hypertension: ROAR (Rural, Obese, At Risk)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-A(70)R]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Microbiome;Prevention

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

PHR: Project Narrative Based on our recent findings we propose that oral commensals methylate host cell DNA, and in this process promote tumor growth and compromise immune responses. We will test this with microbiota humanized mouse models of colorectal cancer, and patient specimens including tumor organoids. \.

PI_NAMEs: BOARDMAN, LISA ALLYN;GOUNARI, FOTINI ;KHAZAIE, KHASHAYARSHA  (contact);STALEY, CHRISTOPHER

PROJECT_TERMS: Aberrant crypt foci;Ablation;Affect;Age;Antibiotic Therapy;ATAC-seq;Bacteria;bacterial community;Bacteroides fragilis;beta catenin;biobank;Biological;Biological Markers;bisulfite sequencing;Blood;Blood Cells;Blood Tests;Carcinogenesis Mechanism;Cells;Chromatin;Coculture Techniques;Colon;colon bacteria;colon cancer patients;colon carcinogenesis;Colon Carcinoma;Colonic Neoplasms;Colorectal Cancer;colorectal cancer risk;colorectal cancer treatment;Community Networks;Data;Death Rate;demethylation;Development;Disease susceptibility;DNA;DNA Methylation;DNMT3a;Epigenetic Process;epigenome;Epithelial Cells;Epithelium;Exclusion;Exposure to;fecal microbiota;Feces;Fusobacterium nucleatum;Gene Expression;Genes;Genetic;Germ-Free;Growth;gut colonization;Histopathology;Human;human microbiota;humanized mouse;Hypermethylation;Hypoxia;Immune response;Immunity;Immunology;Immunology procedure;improved;indexing;Individual;Inflammation;intestinal epithelium;Intestines;Invaded;Lactobacillus acidophilus;Large Intestine;Leukocytes;Link;Malignant Neoplasms;Methylation;methylome;Methyltransferase Gene;Microbe;microbial colonization;microbial community;microbiome;microbiota;mouse model;Mucous Membrane;Mus;Mutation;neoplastic cell;Oral;oral bacteria;Oral cavity;oral commensal;oral pathogen;Organoids;pathogen;Pathogenicity;Patients;Pattern;Prevention strategy;Process;Regulator Genes;Reporting;Risk Factors;risk stratification;Signal Pathway;Specimen;stem cells;suckling;T-Lymphocyte;Testing;therapy resistant;Tissues;transcriptome;transcriptome sequencing;tumor;tumor growth;Tumor Immunity;Tumor Promotion;Weaning

PROJECT_TITLE: Epigenetic mechanisms of carcinogenesis by Parvimonas micra, an oral cavity commensal turned colon cancer pathogen

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Hypertension;Nutrition;Obesity;Prevention;Rural Health;Social Determinants of Health;Women's Health Research

PHR: Chronic consumption of a diet high in saturated fat causes obesity, dyslipidemia, insulin resistance, diabetes, renal dysfunction, and hypertension. The first study to show diets high in saturated fat are directly associated with cardiovascular disease was published in 1978, yet the average American continues to consume twice the daily recommended amount of saturated fat. A better understanding of the mechanisms by which a diet high in saturated fat increases blood pressure will improve treatment options for both men and women and reduce the overall cardiovascular risk burden in the United States.

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Adoptive Transfer;Adult;Affect;Age;American;Animal Experiments;Automobile Driving;Awareness;Black race;Blood Pressure;blood pressure control;blood pressure elevation;Body mass index;Body Weight;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cells;Cessation of life;Chronic;Clinical;cohort;Consumption;Coronary heart disease;cytokine;Dahl Hypertensive Rats;Data;Development;Diabetes Mellitus;Diet;Disease;Dyslipidemias;Environmental Risk Factor;Epidemiology;epidemiology study;experimental study;Fatty acid glycerol esters;Female;Gender;Gene Expression Profile;Genetic;Genetic Models;high body mass index;High Fat Diet;Human;human subject;Hypertension;IL18 gene;Immune;immune activation;Immune response;Immune system;improved;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;insight;Insulin Resistance;Intake;Interleukin-1 beta;Kidney;kidney dysfunction;Knock-out;Knowledge;Link;Macrophage;Macrophage Activation;male;Measures;Mediating;men;Metabolic;Metabolism;metabolomics;Molecular;monocyte;mortality;Nonesterified Fatty Acids;novel;novel strategies;Obesity;Organ;peripheral blood;pharmacologic;Predisposition;premature;prevent;Production;Publishing;Rattus;Recommendation;recruit;response;Risk;Role;Rural;saturated fat;sensor;sex;Sex Differences;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Thinness;Tissue Expansion;Tissue Transplantation;Translating;United States;Vascular Diseases;Woman;women versus men;Women's mortality;Work;young woman

PROJECT_TITLE: Mechanisms Driving Enhanced Susceptibility of Females versus Males to High-Fat Diet-Induced Increases in High Blood Pressure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-A]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

PI_NAMEs: BAUER, MARK C (contact);KAHN, CARMELLA ;TEUFEL-SHONE, NICOLETTE I;WILSON, JAMIE


ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE African American women are disproportionally covered by Medicaid and are at greater risk than non-Hispanic white women of losing insurance coverage after pregnancy and of poor maternal health outcomes. Dr. Steenland will train in domestic health policy, maternal health, and advanced econometric methods to prepare her to complete her research aims and for a career as an independent investigator focused on health policy solutions to reduce poor maternal health outcomes among racial/ethnic minority women. In the proposed research aims, Dr. Steenland will examine the effect of Medicaid expansion on disparities in postpartum insurance coverage nationally, and the effect of Medicaid expansion in Arkansas, the state with the largest coverage gains after Medicaid expansion, on disparities in postpartum health care use in Arkansas.

PI_NAMEs: STEENLAND, MARIA WARD (contact)

PROJECT_TITLE: Reducing Postpartum Health Care Disparities through Increased Insurance Coverage after Childbirth

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Hypertension;Lupus;Nutrition;Obesity;Rural Health;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE Autoimmune diseases such as systemic lupus erythematosus (SLE) collectively impact approximately 24 million Americans, and cardiovascular disease is one of the leading causes of morbidity and mortality in this patient population. The presence of both obesity and elevated leptin have been shown to correlate with increased disease activity in SLE patients, but mechanistic contributions of these factors to autoimmune disease progression and the development of hypertension are poorly understood. This proposal will examine the pathogenic role of obesity and leptin in the development of autoimmune-associated hypertension.

PI_NAMEs: TAYLOR, ERIN BASSFORD (contact)

PROJECT_TERMS: adipokines;Adipose tissue;Adrenergic Receptor;Affect;American;antagonist;anti-dsDNA antibodies;Appetite Regulation;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;autoreactive B cell;autoreactivity;Awareness;B-Lymphocytes;Blood Pressure;Body mass index;Bone Marrow;Brain;Cardiovascular Diseases;CD4 Positive T Lymphocytes;Cells;Central obesity;Chronic;Clinical Data;clinically relevant;comparison control;Control Animal;Data;Deposition;Development;Diet;Disease;Disease Progression;Energy Metabolism;eosinophil;Exhibits;Fatty acid glycerol esters;Female;Flow Cytometry;Functional disorder;Goals;Hematopoietic;High Fat Diet;Homeostasis;Hypertension;hypertensive;Hypothalamic structure;Immune;immune function;Immune system;Immune System Diseases;Immunoglobulin G;Immunoglobulin M;improved;In Vitro;in vivo;Inflammation;Inflammatory;insight;Intervention;Kidney;Knowledge;Laboratories;Lead;Leptin;leptin receptor;LoxP-flanked allele;Lupus;Mediating;Modeling;Morbidity - disease rate;mortality;Mus;nestin protein;Normal Range;Obesity;Operative Surgical Procedures;Overweight;Pathogenesis;Pathogenicity;patient population;Patients;Peripheral;pharmacologic;Population;Pristane;Production;Publishing;Risk;Role;Rural;Self Tolerance;Signal Pathway;Signal Transduction;Sympathetic Nervous System;Systemic Lupus Erythematosus;T cell infiltration;T-Lymphocyte;Techniques;Testing;Tissues;treatment effect;Visceral;Woman;women's treatment

PROJECT_TITLE: The Impact of Obesity and Leptin on the Development of Immune System Dysfunction and Hypertension in Females with Systemic Lupus Erythematous


NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Project Narrative Inflammation is a hallmark of many diseases, including cancer, autoinflammatory disorders, immunodeficiencies, and neurodegeneration; thus, understanding the molecular mechanisms regulating inflammation is critical to identifying opportunities for therapeutic intervention. The signaling pathway identified in this proposal represents a completely novel mechanism by which an apoptotic caspase controls inflammation via a network of proteins with both recognized and unknown roles in inflammation. Mechanistic elucidation of this pathway will shed light on fundamental biology and enable novel therapeutic strategies.

PI_NAMEs: GITLIN, ALEXANDER  (contact)

PROJECT_TERMS: adaptive immunity;Adaptor Signaling Protein;Affect;Agonist;Anti-Inflammatory Agents;Apoptosis;Apoptotic;Appointment;Area;autoimmune lymphoproliferative syndrome;Autoimmunity;autoinflammatory diseases;Award;Binding Proteins;Biochemistry;Biological Process;Biology;career;Career Mobility;CASP8 gene;Caspase;CD95 Antigens;Cell Culture Techniques;Cell Death;Cells;Cellular Immunology;Cessation of life;Clinical;Clinical Competence;Clinical Pathology;Clustered Regularly Interspaced Short Palindromic Repeats;Communicable Diseases;Competence;constriction;cytokine;Data;Dedications;Disease;Disease Progression;Endowment;Evaluation;expectation;experience;Faculty;faculty support;Funding;Gene Expression;Genetic;Genetic Transcription;Genetically Engineered Mouse;genome editing;genome-wide;Goals;Health;High-Throughput Nucleotide Sequencing;Human;Image;Immune;immune activation;Immune System Diseases;Immunity;immunodeficiency;Immunologic Receptors;Impairment;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response Pathway;insight;Institution;instructor;Knock-in;Knowledge;Laboratories;Leadership;Licensing;Ligands;Link;Macrophage;Malignant Neoplasms;Mediating;Medical;Medicine;meetings;Mentors;Mentorship;Molecular;Mutation;Natural Immunity;Nerve Degeneration;new therapeutic target;NF-kappa B;novel;novel therapeutic intervention;Pathologic;Pathology;Pathway interactions;Patients;Peer Review;Phase;phosphoproteomics;Phosphotransferases;Physicians;Positioning Attribute;Postdoctoral Fellow;Production;Proteins;Publications;Regulation;Research;Research Personnel;Research Proposals;Residencies;Resistance;response;Role;Rotation;Scientist;senior faculty;Series;Signal Pathway;Signal Transduction;single cell analysis;Source;Students;System;T-Lymphocyte;TBK1 gene;Techniques;Technology;Therapeutic Intervention;TLR1 gene;TLR3 gene;TLR4 gene;TLR7 gene;TNF gene;TNFSF6 gene;Toll-like receptors;Training;Transcript;Transferable Skills;undergraduate student;United States National Institutes of Health;Universities;Visit;Work

PROJECT_TITLE: Regulation of Proinflammatory Cytokine Responses by a Caspase-8-N4BP1 Axis


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE A leukemia called T-ALL cannot be cured by current treatments in more than half of adult patients. This project will test novel experimental drug affecting tumor metabolism, alone and in combinations, for suppression of ALL disease development in laboratory models. Phase I/II clinical trial will examine safety and efficacy of combinations with standard chemotherapy in relapsed/refractory ALL.

PI_NAMEs: KONOPLEVA, MARINA Y (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: 3-Dimensional;acute lymphoblastic leukemia cell;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Acute T Cell Leukemia;acute T-cell lymphoblastic leukemia cell;Adult;Adult Precursor T Lymphoblastic Leukemia;Advanced Malignant Neoplasm;Affect;asparaginase;Bioenergetics;Biological Assay;Biology;biomarker evaluation;Bone Marrow;Bone Marrow Cells;Cancer Science;candidate identification;candidate marker;Cell Line;Chemoresistance;chemotherapy;Childhood Precursor T Lymphoblastic Leukemia;Citric Acid Cycle;Clinical Trials;Coculture Techniques;Combination Drug Therapy;Combined Modality Therapy;Complex;Cytometry;Data;Development;Disease;Doctor of Medicine;Dose;Drug Kinetics;Drug Screening;first-in-human;Future;Gene Expression Profile;Genetic;Genus Hippocampus;Glycolysis;Growth;Hematologic Neoplasms;high throughput screening;Homeostasis;human subject;Hypoxia;Hypoxia Inducible Factor;Impairment;In Vitro;in vivo;in vivo imaging;in vivo two-photon imaging;Induction of Apoptosis;Infiltration;inhibitor;insight;Laboratories;Lactate Transporter;leukemia;leukemia initiating cell;Libraries;lymphoblast;Lymphoma;Malignant Neoplasms;Maximum Tolerated Dose;Measures;Metabolic;metabolic imaging;Metabolic stress;Metabolism;metabolomics;Microscopy;Mitochondria;Modeling;Molecular;mouse model;Mus;NADH;nanomolar;next generation;novel;Oncogenic;Oxidative Phosphorylation;Oxygen;Oxygen Consumption;Pathway interactions;patient derived xenograft model;Patients;Pegaspargase;peripheral blood;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Phase;Phase I Clinical Trials;Phase I/II Clinical Trial;phase II trial;phosphorescence;Phosphorylation Inhibition;Population;preclinical study;predictive marker;Proliferating;Property;Proteomics;Recommendation;Refractory;Regimen;Regulation;Relapse;Reporting;resistance mechanism;Respiration;Respiratory Chain;response;response biomarker;Role;Safety;Schedule;screening;Stromal Cells;success;synergism;System;Technology;Testing;Therapeutic;Time;Toxic effect;transcriptome sequencing;Translating;tumor;tumor metabolism;two-photon;Work

PROJECT_TITLE: Targeting mitochondrial complex I in acute lymphoblastic leukemia

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: FARMINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative I seek to identify how individuals can lessen deleterious health effects due to air pollution. My primary research objective is to investigate how an individual's commuting choices influence personal exposure to traffic pollutants and the severity of subsequent acute health effects.

PI_NAMEs: ZAMORA, MISTI LEVY (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Acute;Air;Air Pollutants;Air Pollution;ambient air pollution;Area;Aromatic Polycyclic Hydrocarbons;Automobile Driving;Baltimore;Benzene;Bicycling;Biological;Biological Availability;Biological Markers;Blood Pressure;Carbon Dioxide;Cardiovascular system;Chemicals;Cities;cohort;Commuting;Complement;Data;Death Rate;Dose;dosimetry;Emerging Technologies;Environmental Health;Epidemiologist;ethylbenzene;Exercise;Exposure to;Forced expiratory volume function;Funding;Goals;Health;Health Benefit;Hour;improved;Individual;Infrastructure;Intervention Studies;Knowledge;Life Style;Location;Measurable;Measurement;Measures;member;Mentors;Methods;metropolitan;Minor;Monitor;mortality;Nitrogen Dioxide;Noise;novel;oxidative DNA damage;Oxidative Stress;Ozone;Participant;Particulate Matter;Patient Recruitments;Personal Behavior;Persons;Phase;Physical activity;pollutant;Pollution;Positioning Attribute;Publishing;Pulmonary Inflammation;Pulse Pressure;recruit;Reporting;Research;Research Personnel;Resources;Respiration;respiratory;Route;Sampling;Scientist;Severities;Silicones;skills;systemic inflammatory response;Time;Toluene;toxicant;traffic-related air pollution;Transportation;Travel;urinary;Vital capacity;Walking;Work;Workplace;wristband;Xylene

PROJECT_TITLE: Impacts of modifiable factors on personal exposures and acute health

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Hypertension;Immunotherapy;Kidney Disease;Lupus;Nutrition;Obesity;Rural Health;Social Determinants of Health;Women's Health Research

PHR: Immune system activation has been linked to the development of hypertension and is also directly linked to rheumatic diseases like systemic lupus erythematosus (SLE) that predominantly affect women. This proposal will explore how immune system activation during SLE impacts kidney function and leads to hypertension with a focus on understanding a specific immune cell type (neutrophils) and the powerhouse of cells (mitochondria). Examining how the immune system impacts blood pressure during this disease will not only provide new insights for women with SLE, but also will add to the overall understanding of hypertension.

PI_NAMEs: RYAN, MICHAEL  (contact)

PROJECT_TERMS: absorption;Affect;Antibody titer measurement;Antigens;Antioxidants;Attenuated;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;Automobile Driving;Awareness;Blood Pressure;Blood Vessels;C-reactive protein;Cardiovascular Diseases;cardiovascular risk factor;Cell surface;cell type;Cells;Cellular Stress;Chronic;Clinical;Clinical Data;clinical data repository;Clinical Markers;cohort;Complement;Data;Databases;Development;Disease;Erythrocyte Sedimentation Rate;Essential Hypertension;Exhibits;extracellular;Female;Generations;Genetic;Genetic Models;Heat shock proteins;HMGB1 gene;Human;human model;Hypertension;Immune;Immune system;Immunoglobulins;Immunologics;Immunosuppression;Immunotherapy;Impairment;improved;in vivo;Inflammasome;Inflammation;inflammatory marker;Informatics;Infrastructure;Innate Immune Response;innovation;insight;Kidney;Kidney Diseases;kidney vascular structure;Laboratories;Ligands;Link;Literature;Low Prevalence;Lupus;Lymphocyte;Measures;Mediating;men;Methods;Mitochondria;mitochondrial dysfunction;Modeling;mortality;mouse model;Mus;Natural Immunity;neutrophil;novel;Obesity;Oxidative Stress;Pathogenicity;Pathway interactions;pharmacologic;Pharmacotherapy;Physiological;Population;Prevalence;Production;Publishing;Reactive Oxygen Species;Renal function;Rheumatism;Rheumatoid Factor;Risk;Role;Rural;Serum;Signal Transduction;Sodium;Source;Systemic Lupus Erythematosus;Testing;Tissues;TLR4 gene;Tubular formation;United States Department of Veterans Affairs;Uric Acid;Woman;young woman

PROJECT_TITLE: Innate Immune Mediated Changes in Renal Function to Cause Hypertension in Females with Autoimmune Disease


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Hypertension;Obesity;Rural Health;Social Determinants of Health;Women's Health Research

PHR: Approximately 19 million deaths were attributed to cardiovascular disease (CVD) globally in 2020, an increase of ~20% from 2010, yet awareness of this is low, particularly among women in rural communities and from non- white communities. This proposal will increase understanding of the science behind how CVD impacts women and build community relationships to improve awareness in culturally diverse populations in the Southeastern United States. The proposed Leadership Administrative Core will support all aspects of this project to ensure that the goals are met.

PROJECT_TERMS: Adult;Advisory Committees;Age;Awareness;Black Populations;Blood Pressure;blood pressure control;Businesses;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;career;Cause of Death;Cessation of life;Clinical;Collaborations;Committee Members;Communication;Communities;community building;community engagement;community partners;data integration;Development;Education;Educational Activities;Emerging Technologies;Ensure;Faculty;Female;Funding;Goals;Grant;Human Resources;Hypertension;improved;Information Dissemination;Information Systems;innovation;Institution;inter-institutional;Leadership;Location;male;Medical center;medical schools;meetings;men;Methods;Mississippi;modifiable risk;Monitor;mortality;next generation;Obesity;Observational Study;operation;Participant;Patients;Peer Review;Pharmaceutical Preparations;Population;Population Heterogeneity;premature;pressure;Prevalence;Program Reviews;programs;Relative Risks;Reporting;Research;Research Personnel;Research Project Grants;Resources;Review Committee;Risk;Rural;Rural Community;Science;Scientific Advances and Accomplishments;Services;sex as a biological variable;South Carolina;Southeastern United States;success;symposium;Training;United States National Institutes of Health;Universities;Woman;Women's mortality;Work;young woman

PROJECT_TITLE: Improving awareness of women with hypertension: ROAR (Rural, Obese, At Risk) - Leadership Administrative Core (LAC)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Niemann-Pick disease type C (NPC) is a fatal neurodegenerative disease bear striking resemblances with Alzheimer’s disease (AD) and has no cure. This project will investigate how an innate immune pathway drives neuropathology in the NPC disease. This project will also develop and test targeted therapies against this innate immune pathway that may be used to treat the NPC disease and possibly other neurodegenetive diseases in the future.

PI_NAMEs: YAN, NAN  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Adaptor Signaling Protein;Alzheimer's Disease;antagonist;Biology;Brain;brain tissue;Cell Death;Cell Separation;Cell Survival;cell type;Cells;Cerebellum;Cessation of life;Childhood;Cholesterol;Clinical;cofactor;Cre-LoxP;Cyclic GMP;Cyclodextrins;Data;Defect;Disease;DNA;DNA Sequence Alteration;Endoplasmic Reticulum;FDA approved;frontotemporal lobar dementia amyotrophic lateral sclerosis;Future;Genes;Genetic;Goals;Golgi Apparatus;Hepatomegaly;Immune;induced pluripotent stem cell;inhibitor;innate immune pathways;innovation;Integral Membrane Protein;Interferons;IRF3 gene;Knock-out;Knockout Mice;Label;Ligands;Lipids;Lysosomes;Mediating;microbial;Microglia;Modeling;motor function improvement;Mus;Natural Immunity;Neimann-Pick's Disease Type C;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;Neurologic;neuron loss;neuropathology;Niemann-Pick Diseases;NPC1 gene;Parkinson Disease;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;prevent;Process;progressive neurodegeneration;Proteins;Proteomics;Publishing;Purkinje Cells;Research;sensor;Signal Transduction;single-cell RNA sequencing;Splenomegaly;targeted treatment;Testing;Therapeutic;Tissues;trafficking;transcription factor;Wild Type Mouse

PROJECT_TITLE: Mechanism of STING-mediated Neuropathology in Niemann-Pick Disease

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Skin Cancer

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: NARRATIVE  While monoclonal antibodies inhibiting immune checkpoints (ICI) and CAR T-cell therapies are able to restore antitumor immunity and have dramatically changed the therapeutic options for many cancer patients, up to 60% of patients will experience immune-related adverse events (irAE) depending on the tumor type and ICI. The importance of predicting and managing immunotherapy-related adverse events has already been identified as a critical gap in knowledge and clinical practice. Targeting a common molecular node of integration between the various inflammatory mechanisms of irAE, we have developed a novel positron emission tomography (PET) radiopharmaceutical that provides a robust reagent for mechanism-based studies and quantitative characterization of inflammatory foci and immunotherapy-mediated irAE by PET in combination with multiplexed analysis of biologic materials.

PI_NAMEs: NEELAPU, SATTVA S;PIWNICA-WORMS, DAVID  (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Adverse event;Autoimmunity;Biochemical;Biocompatible Materials;Biological Markers;Biology;bioluminescence imaging;Biotechnology;Cancer Patient;CAR T cell therapy;Cells;checkpoint inhibition;checkpoint therapy;clinical imaging;clinical practice;Collagen Arthritis;Cytometry;diagnostic value;Diet;Disease;experience;Generations;Goals;Hematologic Neoplasms;Hot Spot;humanized mouse;Image;Immune;immune activation;immune checkpoint;immune effector cell-associated neurotoxicity syndrome;immune-related adverse events;Immunologic Monitoring;Immunological Models;Immunotherapy;in vivo;Infiltration;Inflammation;Inflammatory;Innate Immune System;insight;Investigation;Iron;Kinetics;Knowledge;Macrophage;Macrophage Colony-Stimulating Factor;Mediating;Melanoma;Metabolic syndrome;Modeling;Molecular;molecular imaging;Monitor;Monoclonal Antibodies;mouse model;Myelogenous;NADPH Oxidase;Naphthols;Natural Immunity;Nature;neurotoxicity;neutrophil;Neutrophil Infiltration;Nitrogen;nonalcoholic steatohepatitis;novel;Organ;Oxidants;Oxidation-Reduction;Oxygen;Participant;Pathway interactions;Patients;Peroxidases;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;Process;Production;Proteins;Radiopharmaceuticals;radiotracer;Reaction;Reactive Oxygen Species;Reagent;recruit;Reporting;response;Role;Series;Serum;Serum Markers;Sex Differences;side effect;Signal Transduction;Signaling Molecule;small molecule;Superoxides;Therapeutic;Tissue imaging;Tissues;tumor;Tumor Immunity;Validation;whole body imaging

PROJECT_TITLE: [18F]4FN PET Imaging of Innate Immunity Activation During Immunotherapy-Induced Adverse Events

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative We have assembled a multi-institutional collaborative center with the aim of creating a cellular taxonomy of molecularly defined cell types in the developing human, Rhesus macaque, and marmoset brain. Our project employs technologies for automated single nucleus and spatially-resolved RNA-sequencing and single cell transposase accessible chromatin sequencing to create spatial gene expression and epigenomic developmental expression maps for human and NHP brain. We will sample 30 brain regions at four key epochs of development and register our cellular data onto MRI-based Common Coordinate Frameworks to create a unique resource that will serve as a blueprint for studies of human brain function and selective vulnerability of cell types to disease and will provide foundational data for the development of primate and in vitro models.

PI_NAMEs: BHADURI, APARNA ;HUANG, HAO ;KRIEGSTEIN, ARNOLD  (contact);LEVINE, JON E;POLLEN, ALEXANDER A;SESTAN, NENAD

PROGRAM_OFFICER_NAME: YAO, YONG

PROJECT_TERMS: 3-Dimensional;Adolescence;Adult;Age;Anatomy;ATAC-seq;Atlases;autism spectrum disorder;Brain;brain cell;Brain region;brain tissue;Callithrix;Callithrix jacchus jacchus;Cell Lineage;Cell Nucleus;cell type;Cells;Cellular Assay;Censuses;Childhood;Chromatin;Communities;comparative;Complex;Computer Analysis;Country;Data;Data Analyses;data framework;data integration;Data Set;Development;differential expression;Disease;Epigenetic Process;epigenome;epigenomics;Etiology;Evolution;Freezing;Gene Expression;Generations;Genes;genetic signature;Genomics;Goals;Health;Human;human disease;human model;human tissue;improved;in vitro Model;innovation;insight;Institution;Laboratories;life span;Macaca;Macaca mulatta;Magnetic Resonance Imaging;Maps;Modality;Molecular;Monitor;multidisciplinary;multiple omics;Neonatal;Neuroanatomy;Neurodevelopmental Disorder;neuropsychiatric disorder;nonhuman primate;Pattern;Population;Positioning Attribute;Pregnancy;primate development;Primates;Procedures;Property;Protocols documentation;Regulatory Element;Research;Resolution;Resources;RNA;Sampling;Schizophrenia;Series;single nucleus RNA-sequencing;Spatial Distribution;Specimen;Taxonomy;Technology;transcriptome sequencing;transcriptomics;Transposase;Validation;Visualization

PROJECT_TITLE: A Multidisciplinary Center for Developing Human and Non-human Primate Brain Cell Atlases


ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: The research plan we propose aims at a comprehensive multi-level understanding of how the brain and the body interact to respond adaptively to a potentially harsh and unforgiving environment. Among the many internal factors that are under constant homeostatic regulation, we focus on the bi-directional dialogue between the brain and the heart, since the cardiovascular system and its role in regulating oxygen delivery is one of the most critical and universal control systems within the animal kingdom. A central aspect of our approach is the generation of a complete brain and body connectome of the larval zebrafish, a map which will be the first ever generated in a vertebrate, and which will be critical in both testing the validity of many extant models, and perhaps discovering new pathways within the interconnected neural circuits that serve the changing needs of the body during behavior.

PI_NAMEs: ENGERT, FLORIAN  (contact);FAIRHALL, ADRIENNE L;FISHMAN, MARK C;LICHTMAN, JEFF W;VOGELSTEIN, JOSHUA T

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Adaptive Behaviors;Address;Algorithms;Animals;Articulation;automated segmentation;Autonomic ganglion;Autonomic nervous system;Behavior;Behavior Control;Behavioral;Behavioral Assay;Behavioral Model;behavioral response;Biological Assay;Brain;brain control;Cardiac;Cardiovascular system;cell type;Cells;Central Nervous System;Classification;Computational algorithm;connectome;connectome data;Cues;Data;Data Set;Dissection;dynamic system;Elements;Environment;Event;experience;experimental study;Fatigue;Feedback;Fishes;flexibility;Frequencies;Functional Imaging;Generations;Goals;guided inquiry;Heart;Homeostasis;Hunger;Image;imaging study;interest;Interneurons;Interoception;Knowledge;Light;Machine Learning;Maps;Measurement;Measures;Mediating;Methods;Mind;mind body interaction;Modeling;Monitor;Motivation;Motor;Motor Neurons;Nervous System;neural;neural circuit;Neural Interconnection;neural model;Neurons;novel;optogenetics;Organ;Oxygen;patch clamp;Pathway interactions;Physiological;Physiology;Positioning Attribute;Process;Protocols documentation;receptor;Reflex action;Regulation;Reporting;Research;Resolution;Resources;respiratory;response;Rewards;Role;Sensory;Series;Synapses;System;Testing;Time;Validation;Work;Zebrafish

PROJECT_TITLE: The Heart and the Mind: An Integrative Approach to Brain-Body Interactions in the Zebrafish


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Complementary and Integrative Health;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PI_NAMEs: ENGERT, FLORIAN  (contact)

PROJECT_TERMS: Administrator;Advisory Committees;Animals;Behavior;Brain;Budgets;Cardiovascular system;Charge;cohesion;Communities;conflict resolution;connectome;Decision Making;Dedications;Environment;Generations;Goals;Guidelines;Heart;Human Resources;Institution;Manuscripts;Maps;meetings;Mind;mind body interaction;Modeling;neural circuit;Neural Interconnection;Occupational activity of managing finances;Oxygen;Pathway interactions;Preparation;programs;Regulation;Reporting;Research;Research Personnel;Role;Science;Scientist;Structure;System;Testing;timeline;United States National Institutes of Health;Universities;Writing;Zebrafish

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Cardiovascular;Complementary and Integrative Health;Data Science;Drug Abuse (NIDA only);Heart Disease;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

PHR: The research plan we propose aims at a comprehensive multi-level understanding of how the brain and the body interact to respond adaptively to a potentially harsh and unforgiving environment. Among the many internal factors that are under constant homeostatic regulation, we focus on the dialogue between the brain and the heart, since the cardiovascular system and its role in regulating oxygen delivery is one of the most critical and universal control systems within the animal kingdom. Our approach aims to not only explain the core mechanisms of top down cardiac control, but also to provide first insights into what is measured at the level of the heart itself, and what is the nature of the signals that are being sent from the heart to the brain. A central aspect of our approach is the generation of a complete brain and body connectome of the larval zebrafish. This map, the first such map in any vertebrate, will be critical in both testing the validity of many extant models, and perhaps discovering new pathways within the interconnected neural circuits that serve the changing needs of the body during behavior.

PI_NAMEs: VOGELSTEIN, JOSHUA T (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Algorithms;analysis pipeline;Anatomy;Animals;Architecture;Atlases;Behavior;Behavioral;Big Data;Biological Models;Biology;Brain;Brain imaging;Brain region;Cardiac;Cardiovascular system;Cloud Computing;Code;Collaborations;collaboratory;Communities;comparative;Computer software;computerized data processing;computing resources;connectome;Data;Data Collection;data curation;data integration;data management;Data Management Resources;Data Science;Data Science Core;Data Set;data sharing;Data Sources;design;digital;Documentation;Ecosystem;Electron Microscopy;empowerment;Ensure;Environment;Experimental Designs;experimental study;Face;FAIR principles;Feedback;Generations;genomic data;Goals;Heart;Image;improved;Individual;Infrastructure;Ingestion;insight;Institution;International;Internet;Knowledge;Label;laptop;Learning;Link;Maps;Measures;member;Memory;Metadata;migration;Mind;mind body interaction;Modality;model building;Modeling;Modernization;Morphologic artifacts;Nature;neural circuit;Neural Interconnection;Neuroanatomy;Neurosciences;novel;Ontology;open source;open source library;Oxygen;Pathway interactions;Plants;portability;Process;Regulation;repository;Reproducibility;Research;Resolution;Resources;Role;Running;scalable algorithms;Science;Scientist;Services;Shapes;Signal Transduction;Slice;Software Engineering;Surveys;System;Technology;terabyte;Testing;Texture;tool;United States National Institutes of Health;virtual machine;Visualization;web platform;Writing;Zebrafish

PROJECT_TITLE: DATA CORE


NIH_SPENDING_CATS: Aging;Cardiovascular;Heart Disease;Hypertension;Obesity;Prevention;Rural Health;Social Determinants of Health;Women's Health Research

PHR: Approximately 19 million deaths were attributed to cardiovascular disease (CVD) globally in 2020, an increase of ~20% from 2010, and heart disease remains the leading cause of death for men and women in the US. The Career Enhancement Core (CEC) is designed to develop a foundation for long-term relationships among the research, medical and lay communities in GA, MS and SC to bring greater awareness to the risk of CVD in women and the consideration of SABV in CVD research. This will be accomplished through education, mentorship, strategic partnerships, and training of community-engaged researchers to increase research and awareness in at-risk communities throughout the Southeast.

PI_NAMEs: ILATOVSKAYA, DARIA  (contact)

PROJECT_TERMS: Academy;Address;Adult;Age;American Heart Association;Award;Awareness;biomedical scientist;Blood Pressure;blood pressure control;Blood Pressure Monitors;Cardiovascular Diseases;cardiovascular disorder education;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;career;Cause of Death;Cessation of life;Clinical;Collaborations;college;Communication;Communities;community empowerment;community engagement;Community Outreach;community partners;community partnership;design;Development;Education;Educational Materials;Educational workshop;Emerging Technologies;empowerment;Ensure;Equipment;Event;experience;Faculty;Family;Foundations;Goals;Grant;health care availability;Healthcare;healthspan;Heart Diseases;High Risk Woman;Historically Black Colleges and Universities;Hypertension;hypertension control;Improve Access;improved;Individual;innovation;Institution;interest;Laboratories;Lead;Leadership;Medical;Medical Students;member;men;Mentors;Mentorship;Methods;Mission;modifiable risk;Monitor;Needs Assessment;next generation;Obesity;outreach;Patients;Perception;Pharmaceutical Preparations;Physicians;Populations at Risk;Postdoctoral Fellow;pre-doctoral;premature;Program Sustainability;Recommendation;Research;Research Personnel;Research Project Grants;Resources;Risk;Risk Factors;Rural;sabbatical;Schools;Scientist;Self Perception;sex as a biological variable;Sex Differences;student training;Students;success;summer program;synergism;teacher;tool;Training;Training and Education;undergraduate student;Universities;Woman;Women's Health

PROJECT_TITLE: Improving awareness of women with hypertension: ROAR (Rural, Obese, At Risk) Career Enhancement Core


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke;Telehealth

ORG_CITY: Newton

ORG_NAME: BIOSENSICS, LLC

PHR: Narrative BioSensics' newly developed sensor-based technology, called StrokeWearTM, consists of a proprietary software and bilateral wrist-worn sensors that continuously monitor upper extremity movements performed by patients in the home setting and deliver vibratory stimuli to remind patients to use their stroke-affected arm. The goal of the system is to enable patients to achieve levels of upper extremity use during daily activities in the home that will enhance motor recovery and improve function. In this study, we will build upon StrokeWearTM by improving and testing enhanced sensor design, new components to the system for patient monitoring, goal setting, feedback, motivation, and behavior change, and new platforms to enhance engagement of patients with the system.

PI_NAMEs: BONATO, PAOLO ;KEYSOR, JULIE J;VAZIRI, ASHKAN  (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Accelerometer;Achievement;Activities of Daily Living;Advanced Development;Affect;Algorithms;arm;Behavior;behavior change;Behavior Therapy;Behavioral;Bilateral;Chronic;chronic stroke;Classification;Clinical;Clinical Trials;Collection;commercialization;commercialization readiness;Communities;community setting;Companions;Computer software;Consultations;Control Groups;Data;Data Storage and Retrieval;Databases;design;Development;Disasters;efficacy evaluation;efficacy testing;Elements;empowerment;Environment;experience;Feedback;flexibility;Fostering;functional improvement;Goals;group intervention;Health Insurance Portability and Accountability Act;hemiparesis;Home;Home environment;Hospitals;Human Resources;Impairment;improved;Intervention;Learning;Legal patent;Life;Limb structure;Monitor;Motivation;Motor;Motor Activity;motor control;motor function recovery;motor recovery;Movement;Neuronal Plasticity;novel;novel strategies;patient engagement;Patient Monitoring System;Patients;Pattern;Performance;Phase;Portal System;primary endpoint;programs;prototype;randomized, clinical trials;Recovery;Rehabilitation therapy;remote monitoring;Secure;Self Efficacy;sensor;sensor technology;Services;Side;Small Business Innovation Research Grant;smartphone application;Stimulus;Stroke;stroke survivor;System;Techniques;Technology;telehealth;Testing;Therapeutic;Time;Training;treatment as usual;Upper Extremity;Visit;wearable sensor technology;web portal;Work;Wrist

PROJECT_TITLE: StrokeWear: A Novel Wrist Wearable Sensor System to Promote Hemiparetic Upper Extremity Use in Home Daily Life.