NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Electronic Nicotine Delivery Systems;Machine Learning and Artificial Intelligence;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_NAME: NATIONAL OPINION RESEARCH CENTER

PHR: PROJECT NARRATIVE  Social media have been increasingly used to disseminate e-cigarette use prevention messages, however, very limited research has comprehensively examined the amount, themes, and sources of these campaigns and the social networks embedded in the campaign conversations. This project will fill this gap by measuring reach and engagement of such campaigns and analyzing comparative themes, major strategies countering these interventions, and the social networks upon which campaign effectiveness depends. These insights will then be used to develop concepts and technologies to help create effective social media campaigns preventing e-cigarette use among youth and young adults.

PI_NAMEs: FENG, MIAO  (contact)

PROGRAM_OFFICER_NAME: D'ANGELO, HEATHER

PROJECT_TERMS: Advanced Development;Advertising;Advocacy;Advocate;Antismoking;Attention;Attitude;Behavior;Brain;Cigarette;cigarette smoking;Clutterings;combat;combustible cigarette;Communication;Community Health;community organizations;comparative;Confusion;Consensus;Consumption;COVID-19 pandemic;design;Development;Devices;Diffuse Pattern;Diffusion;digital media;Effectiveness;effectiveness evaluation;Electronic cigarette;electronic cigarette use;Electronic Nicotine Delivery Systems;Environment;Exposure to;Foundations;Freedom;Frequencies;Future;Gatekeeping;Harm Reduction;Health;Health behavior;health organization;improved;Individual;innovation;insight;Intervention;Linguistics;Machine Learning;Marketing;Measures;Media Campaign;Media Intervention;media use;Misinformation;non-cigarette tobacco product;Nonprofit Organizations;Pattern;peer;Policies;Prevalence;prevent;Prevention;prevention effectiveness;Probability;Process;programs;promoter;Public Health;Published Comment;Reporting;Research;respiratory health;response;Risk;Sales;Science;Semantics;Smoking;smoking cessation;Social isolation;social media;Social Network;social structure;Source;Technology;Teenagers;theories;TikTok;Time;Tobacco;tobacco control;Tobacco Dependence;tobacco products;Tobacco use;tool development;Twitter;vaping;young adult;Youth

PROJECT_TITLE: Using Innovative Machine Learning to Detect Organized Support and Opposition to E-cigarette Use Prevention Campaign Messaging on Twitter and TikTok

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PI_NAMEs: HAWLEY, SARAH T (contact)

PROJECT_TERMS: Achievement;Advisory Committees;Advocate;anti-cancer research;Basic Science;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;Cancer Patient;Cancer Science;career;career development;Career Mobility;Catchment Area;Clinical;Clinical Research;Clinical Sciences;community engagement;Community Outreach;Country;Dedications;Development;Developmental Therapeutics Program;early-career faculty;Education;Education and Outreach;empowerment;Ensure;Environment;Equity;equity, diversity, and inclusion;experience;Faculty;Family;Fostering;Funding;Future;Generations;Glossary;Health;Health Policy;Hematopoiesis;high school;Home;Immunology;improved;Individual;innovation;International;Investments;Justice;Lead;Learning;Link;Malignant Neoplasms;member;Mentors;Michigan;next generation;novel;Oncology;Patient-Focused Outcomes;Patients;Population;Population Research;Population Sciences;Process;programs;Provider;Research;Research Personnel;Research Training;Role;Science;Shapes;Signal Transduction;Specialist;success;Training;Training and Education;Training Programs;Translating;Translational Research;tumor microenvironment;Universities

PROJECT_TITLE: Cancer Research Training and Education Coordination

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Biotechnology;Cancer;Prevention

PI_NAMEs: PASCA DI MAGLIANO, MARINA  (contact)

PROJECT_TERMS: Achievement;Affect;Animal Model;Area;Award;Basic Science;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;cancer prevention;Cells;cellular imaging;Clinical Research;Collaborations;college;community engagement;Community Outreach;Data Science;Detection;Development;Developmental Therapeutics Program;Diagnosis;Diagnostic;Doctor of Philosophy;Drug Kinetics;Drug Screening;Early Diagnosis;Epithelium;extracellular;Faculty;Fibroblasts;Flow Cytometry;Funding;Future;Glossary;Goals;Grant;Growth;health communication;Hematopoiesis;Heterogeneity;Homeostasis;Immune;Immunity;Immunologic Monitoring;Immunology;improved;Inflammation;insight;interdisciplinary collaboration;interest;Internal Medicine;Invaded;irradiation;Journals;Knowledge;Malignant Neoplasms;member;Mentors;Metabolic;Metabolic Pathway;Metabolism;Metabolite Interaction;Michigan;Microbe;microbiome;Molecular;molecular imaging;molecular pathology;Names;Neoplasm Metastasis;neoplastic cell;novel;novel marker;Operative Surgical Procedures;Pathway interactions;Peer Review;Phenotype;Physiology;Population Sciences;pre-clinical;Prevention;professor;programs;Proteomics;Publications;recruit;Research;Research Personnel;Research Support;Resource Sharing;Role;Scheme;Schools;Seminal;Signal Transduction;single cell analysis;small molecule;Source;stemness;Structure;Therapeutic;Therapeutic Research;therapy resistant;Tissue imaging;Tissues;Training and Education;Transgenic Animals;Translating;Translational Research;treatment response;tumor;tumor initiation;tumor metabolism;tumor microenvironment;tumor progression;tumorigenesis;United States National Institutes of Health;Universities;Work;working group

PROJECT_TITLE: Signaling and Tumor Microenvironment (STME)


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: NARRATIVE  During the onset of type 1 diabetes (T1D), many immune cell types infiltrate into pancreatic islets, but the infiltration of each individual islet varies substantially within an individual mouse or human. We propose experiments to identify the molecular details of transcriptional programs that control immune cell function in pancreatic islets over the onset of T1D. These analyses will deﬁne transcriptional control of autoimmune responses and identify potential therapeutic targets to limit autoimmunity.

PI_NAMEs: FRIEDMAN, RACHEL S;SCOTT-BROWNE, JAMES  (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Address;advanced disease;Antigens;ATAC-seq;Autoantigens;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;autoreactive T cell;autoreactivity;B-Lymphocytes;Bar Codes;Beta Cell;Biological Assay;CD8-Positive T-Lymphocytes;Cell Physiology;cell type;Cells;Chronic;Chronic Disease;Clinical;cytokine;Data;Disease;Disease Progression;disorder control;DNA;exhaust;exhaustion;experimental study;Exposure to;Family;functional genomics;Gene Expression Profile;Genes;Genetic Transcription;Genomic approach;Goals;Human;Immune;immune cell infiltrate;immune function;Immune response;Inbred NOD Mice;Individual;Infection;Infiltration;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;islet;Islet Cell;Islets of Langerhans;Leucine Zippers;Link;Macrophage;Malignant Neoplasms;Methods;Molecular;mouse model;Mus;Myelogenous;Myeloid Cells;novel;Outcome;Pancreas;Pathogenesis;Pattern;Population;programs;Protocols documentation;Publishing;receptor;Regulation;Resolution;response;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Structure of beta Cell of islet;T cell infiltration;T cell regulation;T cell response;T-Lymphocyte;Techniques;Testing;therapeutic target;transcription factor;Transcriptional Regulation;tumor;Virus;Work

PROJECT_TITLE: Single Cell Genomics to Resolve Control of Immune Cell Function During Type 1 Diabetes

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Kidney Disease;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: DOWNERS GROVE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MIDWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative: The proposed research is relevant to public health because vancomycin is the single most commonly administered antibiotic in the hospital setting, causing attributable acute kidney injury in more than 10% of patients and leading to 300,000 potentially preventable new kidney injuries per year. Despite known mechanisms, it is unknown if proximal tubular necrosis via an oxidative mechanism or vancomycin uromodulin complexes leading to obstruction/renal tubular epithelial dam- age is the initiation event that begins a pathway of damage. Defining the inciting mechanism will pave the way for AKI prevention studies that will precisely target: A) avoidance of cellular uptake at the proximal tubule cell for vancomycin and many other nephrotoxins, e.g. megalin mediated uptake or B) tubular conditions the minimize the likelihood of uromodulin complex formation, i.e. osmotic gradient management.

PI_NAMEs: SCHEETZ, MARC HOWARD (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;alternative treatment;Aminoglycosides;Animal Experiments;Antibiotic Therapy;Antibiotics;Biological Markers;Biopsy;Blood;Blood specimen;Caring;Cells;Cessation of life;Cisplatin;Classification;Clinical;clinical implementation;Clinical Trials;Collection;Complex;Contralateral;Creatinine;Critical Illness;Data;design;Detection;Early identification;Early Intervention;Encapsulated;Epithelium;Event;Experimental Designs;experimental study;Family suidae;Future;Glomerular Filtration Rate;glomerular function;Goals;Gold;Guidelines;Histopathology;Hospitals;Human;improved;Injury;injury prevention;Injury to Kidney;innovation;Intubation;Kidney;kidney biopsy;Kidney Diseases;Knowledge;LDL-Receptor Related Protein 2;Mediating;metabolome;metabolomics;methicillin resistant Staphylococcus aureus;Methodology;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;Necrosis;nephrotoxicity;Obstruction;Osmosis;Outcome;Oxidative Stress;Paralysed;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phase;Physiological;Plasma;Polymyxin B;Polymyxins;porcine model;pre-clinical;prevent;Prevention strategy;Preventive measure;Process;programs;Public Health;Reaction;Recommendation;renal damage;Research;Risk;Rodent;Safety;Sedation procedure;Serum;standard of care;Standardization;Staphylococcus aureus infection;Time;Toxic effect;Translating;treatment strategy;Tubular formation;tubular necrosis;UMOD gene;unethical;uptake;urinary;Vancomycin;Venous blood sampling

PROJECT_TITLE: Elucidating the temporal mechanism of vancomycin kidney toxicity as a means to prevent injury

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


PI_NAMEs: CHO, KATHLEEN R. (contact)

PROJECT_TERMS: Address;Advanced Development;Animal Model;anti-cancer research;Arts;Basic Science;Biological Markers;Biological Models;Biology;burden of illness;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;cancer initiation;Cancer Patient;cancer prevention;cancer therapy;cancer type;carcinogenesis;Catchment Area;Cells;cellular imaging;Chromatin Structure;Clinical Management;Clinical Research;Collaborations;college;community engagement;Community Outreach;data integration;Data Science;Defect;Development;Developmental Therapeutics Program;Diagnosis;diagnostic strategy;Drug Kinetics;Drug Screening;Early Diagnosis;Environment;Epigenetic Process;Event;Faculty;Flow Cytometry;Funding;Genes;Genetic;Genetically Engineered Mouse;Genome;Genomic Instability;Glossary;Goals;Grant;health communication;Hematopoiesis;Human;Immunity;Immunologic Monitoring;Immunology;improved;Incidence;Inflammation;Inherited;innovation;insight;Interdisciplinary Study;interest;irradiation;Journals;Kinesiology;Knowledge;knowledge translation;Lesion;Literature;Malignant Neoplasms;medical schools;member;Mentorship;Methods;Michigan;Microbe;Molecular;molecular imaging;molecular pathology;Monitor;Mutation;Names;Nature;new therapeutic target;novel;Patients;Peer Review;Population Sciences;pre-clinical;prevent;Prevention;Prevention strategy;Preventive;programs;Proteomics;Public Health Schools;Publications;Recording of previous events;Recurrence;Regulation;Research;Research Personnel;Research Priority;Research Support;Resistance;Resource Sharing;Risk Assessment;RNA;Schools;Science;screening;Signal Transduction;single cell analysis;Somatic Mutation;Structure;Therapeutic;Tissue imaging;Tissues;Training;Training and Education;Transgenic Animals;Translating;Translational Research;treatment response;tumor microenvironment;tumor progression;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Cancer Genetics (CG)


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: Columbus

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Interferon-lambda (IFN-λ) provides antiviral protection against SARS-CoV-2 and is in clinical trials as a therapeutic for COVID-19, but the endogenous role for IFN-λ its mechanisms in regulating pathogenesis and immunity during SARS-CoV-2 infection remain unknown. Our preliminary data has identified novel roles for IFN-λ promoting CD8 T cell immunity and limiting pulmonary pathogenesis repair programs in a murine model of SARS-CoV-2 infection. This proposal will investigate the mechanisms underlying these non-canonical functions of IFN-λ during SARS-CoV-2 infection to inform therapeutic use in preventing COVID-19.

PI_NAMEs: HEMANN, EMILY ANN (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Adoptive Transfer;Antibody Response;antiviral immunity;Body Weight decreased;CD8-Positive T-Lymphocytes;Cell Cycle;Cell Cycle Regulation;Cell Physiology;Cells;Clinical Trials;COVID-19;COVID-19 pandemic;COVID-19 prevention;COVID-19 therapeutics;cytokine;Data;Dendritic Cells;Development;Disease;draining lymph node;Epithelial Cell Proliferation;Epithelial Cells;epithelial repair;experience;experimental study;Fibrosis;FOXM1 gene;gene induction;Generations;Genes;Goals;Histologic;Human;immune activation;Immune response;Immunity;Immunologic Adjuvants;Immunologic Factors;Immunologist;improved;In Vitro;in vivo;Infection;Influenza;Influenza A virus;innovation;insight;Interferons;Knock-out;knockout animal;Knockout Mice;Lung;Lymphocytic Infiltrate;Mediating;Memory;mouse model;Mucous Membrane;Mus;neutralizing antibody;novel;Pathogenesis;Pathology;Pathway interactions;pharmacologic;post SARS-CoV-2 infection;prevent;Process;programs;Proliferating;receptor;Recombinant Interferon;Recombinants;Recovery;Regulation;repaired;Research;respiratory infection virus;respiratory virus;response;Role;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SARS-CoV-2 pathogenesis;Seminal;severe COVID-19;Signal Transduction;Stains;T cell response;T-Cell Activation;Therapeutic;Therapeutic Uses;therapeutically effective;Time;tissue repair;Tissues;Training;Up-Regulation;Vaccines;Variant;Viral;Viral Genes;Viral Load result;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: NON-CANONICAL MECHANISMS FOR INTERFERON-LAMBDA REGULATION OF SARS-COV-2 INFECTION

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: DE

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease

ORG_CITY: EAST LANSING

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Project Narrative Dental adhesives are employed to create a sturdy and long-lasting bond between dentin and composite restorations, through the formation of a robust hybrid layer comprised of a three-dimensional polymer network that interlocks with native bone tissue. To date, the performance of such adhesives is sub-optimal, as the majority of composite failures are observed at restoration margins. The fundamental goal of this project is to understand the phase structure and composition of heterogeneities that form during adhesive polymerization, and to reinforce weakened regions of the hybrid layer through the development and application of monomers capable of adaptable, dynamic bond rearrangement.

PI_NAMEs: SZCZEPANSKI, CAROLINE ROSE (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;adhesive polymer;Adhesives;Amalgam;analog;Appearance;Appointment;Award;Bacteria;Behavior;Biocompatible Materials;Biological;biomaterial compatibility;Bone Tissue;career;career development;Catechols;Categories;chemical group;Chicago;Clinical;Complex;composite restoration;cost;dental adhesive;Dental Materials;Dental Schools;Dentin;design;Development;Development Plans;driving force;efficacy evaluation;Ensure;Environment;Esthetics;Exposure to;Failure;Fatigue;Formulation;Funding;Goals;Growth;Healthcare;Heterogeneity;Hybrids;Hydrogen Bonding;Illinois;improved;Infiltration;innovation;Institution;Investigation;Laboratory Research;Longevity;mechanical properties;Mechanical Stress;Mechanics;Medicine;Mentors;Mentorship;Methacrylates;Michigan;Modeling;monomer;Morphology;National Institute of Dental and Craniofacial Research;novel;Oral;oral care;Patient Care;Patients;Performance;Phase;photopolymerization;Plant Resins;polymerization;Polymers;Positioning Attribute;Postdoctoral Fellow;Predisposition;programs;Protocols documentation;Pyrimidinones;Recovery;Relaxation;Research;research and development;Research Personnel;Research Project Grants;response;responsible research conduct;restoration;restorative dentistry;restorative material;Route;Science;Series;skills;Specimen;Stress;Structure;success;System;Testing;Training;United States;United States National Institutes of Health;Universities;uptake;Water;Work

PROJECT_TITLE: Reinforcing dental adhesives with monomers capable dynamic rearrangement and self-recovery

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: ZOU, WEIPING  (contact)

PROJECT_TERMS: Address;Animal Model;Automobile Driving;Basic Science;Biological Markers;Biology;biomarker identification;Bone Marrow Transplantation;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;cancer immunotherapy;cancer initiation;cancer therapy;care delivery;Cell Physiology;Cell Therapy;Cells;cellular imaging;Clinic;Clinical Research;Clinical Trials;Collaborations;college;community engagement;Community Outreach;Complement;Data Science;Development;Developmental Therapeutics Program;Diet;Drug Kinetics;Drug Screening;Enrollment;Epigenetic Process;Flow Cytometry;Funding;Genetic;Glossary;Goals;graft vs host disease;health communication;health equity;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Transplantation;Homeostasis;Immune;immune cell infiltrate;immune system function;Immunity;Immunologic Monitoring;Immunology;Immunotherapy;improved;Inflammation;Inflammatory;insight;Institution;interest;Internal Medicine;Intervention;Intervention Trial;irradiation;Journals;Knowledge;Malignant - descriptor;Malignant Neoplasms;member;Metabolic;Methods;Michigan;Microbe;microbiome;microbiota;Mission;Molecular;molecular imaging;molecular pathology;Names;National Clinical Trials Network;Nature;novel therapeutic intervention;Oncology;Operative Surgical Procedures;Outcome;Pathogenesis;Pathway interactions;Patients;Peer Review;Phenotype;Population Sciences;pre-clinical;preclinical study;professor;programs;Proteomics;Publications;Quality of life;Reagent;Reporting;Research;Research Priority;Resistance;Resource Sharing;response;Schools;Science;Shapes;Signal Transduction;single cell analysis;Source;Structure;Survivors;T-Lymphocyte Subsets;Therapeutic;therapeutic development;Therapeutic Intervention;Therapeutic Trials;Time;Tissue imaging;Tissues;Training and Education;Transgenic Animals;Translating;Translational Research;treatment trial;tumor;tumor immunology;tumor metabolism;tumor microenvironment;tumor progression;Tumor-infiltrating immune cells;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Cancer Hematopoiesis and Immunology (CHI)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

ORG_STATE: PA

PHR: PROJECT NARRATIVE ATRX is a frequently mutated protein in neurodevelopmental disorders and in several cancers. ATRX has known function in regulating genome organization. Elucidating its mechanisms and the consequence of ATRX mutations to genome organization will significantly advance our understanding of ATRX malfunction in disease.

PI_NAMEs: SARMA, KAVITHA  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: 3-Dimensional;Affect;Alleles;Architecture;ATRX gene;Behavior;Binding;Binding Sites;Biochemical;Brain;Cell Differentiation process;Cells;Chromatin;chromatin remodeling;Complex;CRISPR/Cas technology;Data;Defect;Deposition;Development;Disease;DNA Methylation;Engineering;Epigenetic Process;epigenetic silencing;Exhibits;Gene Expression;Genes;Genitalia;Genome;genome wide methylation;genome-wide;Genomic Segment;Genomics;Genotype;helicase;Histones;Impairment;imprint;knock-down;Lead;Link;Maintenance;Malignant Neoplasms;Masks;Mediating;Molecular;Mouse Embryonic Stem Cells;mutant;Mutate;Mutation;nerve stem cell;neural;Neurodevelopmental Disorder;Neurologic;Neuronal Differentiation;novel;Oncogene Deregulation;Outcome;Patients;Pattern;PHD Finger;Phenotype;Polycomb;Positioning Attribute;prevent;Process;programs;Proteins;Psychomotor Impairments;Reagent;Regulation;Role;severe intellectual disability;Severity of illness;Site;Syndrome;Testing;Variant

PROJECT_TITLE: CTCF-dependent mechanisms of ATRX in neuronal differentiation

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Prevention;Sleep Research;Substance Misuse

ORG_CITY: ROCHESTER

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative Alcohol use problems and sleep problems each cause significant negative consequences to individuals and to societies. They also happen to occur together very often, with insomnia often making alcohol use worse and diminishing the effects of alcohol treatment. The project will focus on improving sleep with a brief, phone- based, behavioral insomnia intervention as an approach to reduce hazardous alcohol use.

PI_NAMEs: PIGEON, WILFRED R (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Address;Adult;Aftercare;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol effect;alcohol misuse;alcohol use disorder;Alcohols;associated symptom;Award;Back;Behavioral;brief intervention;burden of illness;Bypass;Clinical;cognitive testing;Cognitive Therapy;Communities;comorbidity;comparison intervention;cost;Data;depressive symptoms;design;Development;Diagnostic;diagnostic criteria;drinking;Education;Enrollment;experience;Feasibility Studies;Feeling suicidal;follow up assessment;follow-up;Future;Glean;improved;improvement on sleep;indexing;Individual;Intervention;intervention effect;Manuals;Measurement;Measures;medical specialties;Mental Depression;Mental Health;Methods;modifiable risk;Moods;Morbidity - disease rate;mortality;National Institute on Alcohol Abuse and Alcoholism;open label;Outcome;Outcome Measure;Participant;Patient Recruitments;Patient Self-Report;Patients;Pattern;Phase;physical conditioning;Pilot Projects;Population;Post-Traumatic Stress Disorders;Preparation;Prevention trial;Procedures;Prognosis;programs;prospective;Public Health;randomized trial;Recovery;recruit;Research;Research Design;response;Risk Factors;Sampling;Self Medication;Severities;Sleep;Sleep Disorders;Sleeplessness;social stigma;Societies;substance abuse prevention;Substance Use Disorder;suicidal behavior;symptomatic improvement;Telephone;telephone delivery;Testing;therapy design;therapy development;timeline

PROJECT_TITLE: Addressing Hazardous and Harmful Alcohol use Through an Adapted CBT Sleep Intervention


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Autism;Bioengineering;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Developmental anomalies affect more than 120,000 births annually in the United States; however, the perturbations in embryogenesis that lead to these anomalies have not been identified in many cases including certain neurodevelopmental disorders. The proposed research creates strategies for detailed mapping of developmental events in mammalian model systems to advance the understanding of the genetic factors that contribute to these disorders. These strategies are relevant to public health and the NIH’s mission because they would help determine how genomic mutations disrupt cell proliferation and differentiation during embryogenesis to lead to developmental anomalies.

PI_NAMEs: KALHOR, REZA  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Address;Adult;Affect;autism spectrum disorder;Bar Codes;base editor;Behavior;Biological Models;Birth;Brain;Caenorhabditis elegans;Cell Differentiation process;Cell Lineage;Cell Proliferation;Cells;Chromosome Mapping;combinatorial;Complex;computerized tools;Congenital Abnormality;Data;Development;Developmental Process;Disease;disorder risk;Embryonic Development;Engineering;Environmental Risk Factor;Event;gene editing technology;Gene Mutation;Genetic;genetic risk factor;Genetic Variation;Genome;genome wide association study;Genomics;Goals;Health;Heritability;Human;In Situ;in situ sequencing;in utero;in vivo;Inherited;innovation;insertion/deletion mutation;insight;Label;Lead;Macrocephaly;Mammals;Maps;Measurement;Mission;model of autism spectrum disorder;Molecular;Molecular Analysis;molecular marker;mouse development;mouse model;Mus;Mutagenesis;mutant mouse model;Mutation;Nematoda;nerve stem cell;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;novel;Organism;Outcome;Phenotype;Point Mutation;Positioning Attribute;Pregnancy;Process;progenitor;Proliferating;Public Health;reconstruction;Research;Resolution;stem cell fate;System;Technology;Testing;Tissue Differentiation;Tissues;transcriptome;ultra high resolution;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Mapping the dynamics of mouse neurogenesis in autism models using high-resolution genomic barcoding technologies

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: LEOPOLD, JUDITH S (contact)

PROJECT_TERMS: Animal Model;Antineoplastic Agents;Basic Science;Biological Models;biomarker driven;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;Cancer Patient;cancer therapy;candidate identification;cellular imaging;Clinical;clinical application;clinical candidate;Clinical Investigator;Clinical Research;Clinical Trials;Clinical Trials Design;clinically relevant;Collaborations;college;community engagement;Community Outreach;Data;Data Science;Development;Developmental Therapeutics Program;drug candidate;Drug Kinetics;Drug Screening;Drug Targeting;efficacy evaluation;Epigenetic Process;Evaluation;Flow Cytometry;Funding;Future;Glossary;Goals;health communication;Hematopoiesis;Immunologic Monitoring;Immunology;improved;In Vitro;in vivo;inhibitor;innovation;insight;interest;Intervention;irradiation;Journals;Lead;lead candidate;lead optimization;Malignant Neoplasms;member;Michigan;molecular imaging;molecular pathology;Names;new therapeutic target;novel;novel anticancer drug;patient derived xenograft model;Peer Review;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;Population Sciences;potential biomarker;pre-clinical;Pre-Clinical Model;preclinical development;preclinical evaluation;programs;Property;prospective;protein protein interaction;Proteins;Proteomics;Publications;Publishing;Research;Research Activity;Research Personnel;Research Priority;Research Support;Resource Sharing;response biomarker;safety assessment;Scheme;Schools;Signal Transduction;single cell analysis;small molecule;Source;Structure;Therapeutic Agents;Tissue imaging;Tissues;Training and Education;Transgenic Animals;translational impact;Translational Research;treatment response;tumor;tumor microenvironment;United States National Institutes of Health;Universities;Validation;Work

PROJECT_TITLE: Developmental Therapeutics (DT)


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE Bacteria can be engineered as live therapeutics for broad biomedical applications. The proposed research will enable the creation of safe and effective therapeutic bacteria.

PI_NAMEs: TAN, CHEEMENG  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Address;Bacteria;Cells;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;commensal bacteria;Communities;Devices;Disease;Dose;Drug Delivery Systems;drug synthesis;Ecosystem;Engineering;Ensure;Future;Gene Expression;Genes;Growth;Human body;Hybrids;information processing;interest;Measures;Metabolism;microdevice;Molecular;mutant;Mutation;Patients;preservation;prevent;Proliferating;Protein Biosynthesis;Proteins;Research;Safety;Site;Stimulus;Synthetic Genes;Therapeutic;therapeutically effective;tool;Work

PROJECT_TITLE: Dissecting the non-growing-but-active state of a hybrid bacteria-material microdevice

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: The goal of the proposed research is to understand how certain KRAS-driven lung cancers silence STING and to develop pre-clinical therapeutic strategies that force them to deal with re-activation of this critical DNA sensor. By inducing this antiviral protein and boosting its activity, KRAS-LKB1 mutant lung cancers are forced to deal with consequences, which not only promotes cellular cytotoxicity but also enhanced immunogenicity. These studies build upon our initial efforts to target TBK1 and provide a more straightforward approach to rewire its activity in lung cancer and ultimately have a significant impact on public health.

PI_NAMEs: BARBIE, DAVID A (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Animal Model;anti-PD-1;Anti-viral Response;Antimitotic Agents;autocrine;Autologous;Automobile Driving;Biological Models;Cancer Model;Cell Line;Cell Survival;Cell-Mediated Cytolysis;Cells;checkpoint therapy;chemokine;clinical efficacy;Colorectal Cancer;Combined Modality Therapy;CXCL10 gene;cytokine;cytotoxic;cytotoxicity;Data;derepression;Detection;Development;DNA;DNA Damage;effector T cell;Enzymes;Epigenetic Process;epigenetic silencing;Evaluation;EZH2 gene;Feedback;Genetic;Genetic Transcription;Genetically Engineered Mouse;Goals;Human;Immune;Immune checkpoint inhibitor;Immune signaling;Immunocompetent;immunogenicity;in vivo;Inflammatory;inhibitor;Interleukin-1;Interleukin-6;IRF3 gene;KRAS oncogenesis;KRAS2 gene;Laboratories;Lung Neoplasms;Malignant neoplasm of lung;Measures;Mediating;MEK inhibition;MEKs;micronucleus;Mitochondria;Mitochondrial DNA;Mitotic;Modeling;Mus;mutant;Mutate;Mutation;neoplastic cell;Neutrophil Infiltration;Non-Small-Cell Lung Carcinoma;novel;Oncogenes;Output;Pancreatic Ductal Adenocarcinoma;Pathway interactions;patient derived xenograft model;patient subsets;Patients;PD-1 blockade;PD-1 inhibitors;Phosphotransferases;Play;Population;pre-clinical;preclinical development;predictive marker;Production;Public Health;RANTES;recruit;Refractory;Research;Research Project Grants;Resistance;response;Role;RPS27 gene;sensor;Signal Pathway;Signal Transduction;Specimen;spheroids;STAT1 gene;STAT3 gene;Stimulator of Interferon Genes;STK11 gene;synergism;T cell response;T-Lymphocyte;targeted treatment;TBK1 gene;Therapeutic;TP53 gene;tumor;Tumor Immunity;tumor microenvironment;tumorigenesis;tumorigenic;Tumorigenicity;Up-Regulation;Validation;Viral;Viral Proteins

PROJECT_TITLE: Targeting the cytokine circuitry of KRAS-driven lung cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Cancer;Precision Medicine;Prevention

PI_NAMEs: LAWRENCE, THEODORE S (contact)

PROJECT_TERMS: Animal Model;Area;Biological Markers;Bladder;Breast;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Detection;cancer diagnosis;cancer genetics;cancer initiation;cancer risk;cancer therapy;care delivery;Catchment Area;Cells;cellular imaging;Classification;Clinical Data;Clinical Oncology;Clinical Protocols;Clinical Research;clinical translation;Clinical Trials;Clinical Trials Design;Collaborations;college;Colorectal;community engagement;Community Outreach;data management;Data Science;Developmental Therapeutics Program;Direct Costs;Disease;Drug Kinetics;Drug Screening;Early Diagnosis;Enrollment;Environment;Equity;Flow Cytometry;Funding;Genes;Genetic Determinism;Glossary;Goals;Grant;health communication;Hematopoiesis;Heterogeneity;Immunity;Immunologic Monitoring;Immunology;improved;Industry;Inflammation;innovation;Institution;irradiation;Journals;Laboratories;Life;Link;Liver;Lung;Malignant Neoplasms;Measures;member;Michigan;Microbe;Molecular;molecular imaging;molecular pathology;Molecular Target;Monitor;Multiple Myeloma;Names;National Clinical Trials Network;Nature;novel strategies;Pancreas;Paper;participant enrollment;patient oriented research;patient subsets;Patients;Peer Review;personalized medicine;Physicians;Population Sciences;pre-clinical;predictive marker;Prevention;programs;Prostate;Proteomics;Protocols documentation;Publications;Publishing;Quality of Care;Research;Research Priority;Resistance;resistance mechanism;Resource Sharing;Risk Reduction;Schools;Science;Scientist;Sensitivity and Specificity;Signal Transduction;single cell analysis;Site;Solid Neoplasm;Structure;System;Testing;Therapeutic;Therapeutic Intervention;Therapeutic Trials;Tissue imaging;Tissues;Training and Education;Transgenic Animals;Translating;translational approach;Translational Research;tumor;tumor metabolism;tumor microenvironment;Universities;Uterus

PROJECT_TITLE: Translational and Clinical Research (TACR)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Childhood Obesity;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Human Genome;Liver Disease;Nutrition;Obesity;Pediatric

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE Maternal obesity is a strong risk factor for pediatric nonalcoholic fatty liver disease (NAFLD), which affects 35% of obese youth and up to 10% of all children. Using a nonhuman primate model of maternal obesity, we will investigate mechanisms by which maternal western style diet can reprogram immune cells and liver beginning in fetuses to promote NAFLD and liver fibrosis in juvenile offspring. The results of this study will have direct clinical and translational implications for understanding and potentially halting pediatric NAFLD.

PI_NAMEs: FRIEDMAN, JACOB E (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: 3 year old;Adolescent;Adult;Affect;Age;animal old age;Anti-Inflammatory Agents;ATAC-seq;bile acid metabolism;Bile Acids;Binding;Birth;Bone Marrow;cell injury;Cells;Child;Childhood;Clinical;Collagen;Consumption;Critical Pathways;crosslink;crosslinking and immunoprecipitation sequencing;cytokine;Data;Deposition;Development;Diet;Down-Regulation;Embryo;emerging adult;end stage liver disease;Epigenetic Process;epigenome;Ethnic Origin;Fatty acid glycerol esters;fetal;Fetal Liver;Fetus;Fibrosis;Gene Expression;Genetic Transcription;Glycolysis;Goals;healing;Hematopoietic stem cells;Hepatic;Hepatic Stellate Cell;Hepatocyte;Human;Immune;Immunoprecipitation;Impairment;in utero;In Vitro;Infant;Inflammation;Inflammatory;Inflammatory Response;Injury;Interleukin-4;juvenile animal;Life;life span;Liver;Liver Fibrosis;liver injury;liver metabolism;Longitudinal Studies;Macrophage;maternal obesity;MicroRNAs;migration;Modeling;Modification;Molecular;monocyte;mother nutrition;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;nonhuman primate;novel;obese mothers;Obesity;offspring;Outcome;Overweight;Pathogenesis;Pathway interactions;Patients;pediatric non-alcoholic fatty liver disease;Phenotype;Physiological;Population;Portal triad;postnatal;Predisposition;Prevalence;Production;programs;Race;recruit;response;Risk;Risk Factors;Role;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Site;Socioeconomic Status;stellate cell;Testing;Toddler;transcriptome sequencing;Weaning;western diet;Yolk Sac;Youth

PROJECT_TITLE: Maternal Obesity and Pediatric NAFLD: Fetal Origins and Long-term outcomes in Non Human Primates

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative There is a deluge of health texts. Natural Language Processing (NLP) holds much promise to unravel valuable information from these large data streams with the goal to advance medicine and the wellbeing of patients. We will advance state-of-the-art NLP by designing robust, scalable methods that leverage health big data, demonstrating relevance on high-impact use cases, and disseminating NLP tools for the research community and public at large.

PI_NAMEs: BETHARD, STEVEN ;SAVOVA, GUERGANA K. (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;Adult;Algorithms;Apache;Area;Attention;Big Data;Childhood;Clinical;clinical training;commercialization;Communities;Community Health;Computer software;Computerized Medical Record;Data;Data Set;data streams;deep learning;deep learning algorithm;design;Detection;Development;Educational process of instructing;electronic data;Environment;Evaluation;federated learning;Foundations;Funding;Goals;Health;health data;health knowledge;Healthcare;Information Retrieval;insight;Institution;Investigation;Joints;Knowledge;Knowledge Extraction;learning strategy;Machine Learning;Manuals;Medical;medical specialties;Medicine;method development;Methodology;Methods;model generalizability;Modeling;Modernization;multitask;Names;Natural Language Processing;neural network;Neural Network Simulation;novel;online community;Ontology;open source;Patients;Penetration;Personal Satisfaction;Phenotype;Physicians;point of care;precision medicine;programs;Public Health;Publications;Research;Risk Reduction;social media;software development;Solid;Source;structured data;System;Techniques;Text;Time;tool;Training;Training and Infrastructure;training data;translational medicine;Uncertainty;Unified Medical Language System;Vision;Work

PROJECT_TITLE: Extended Methods and Software Development for Health NLP

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Clinical Research;Dissemination and Implementation Research;Health Services;Lung;Lung Cancer;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: PEARCE, CELESTE LEIGH (contact)

PROJECT_TERMS: Address;Animal Model;Behavior Therapy;Big Data;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Control Research;cancer diagnosis;cancer epidemiology;Cancer Etiology;cancer genetics;Cancer Model;cancer prevention;cancer risk;care delivery;career development;cellular imaging;Clinical;Clinical Research;clinical trial recruitment;Clinical Trials;Communities;community engagement;Community Outreach;Complement;Data;Data Science;Detection;Developmental Therapeutics Program;Drug Kinetics;Drug Screening;Early Diagnosis;Education;Electronic Health Record;Enrollment;Ensure;Epidemiology;Equity;equity, diversity, and inclusion;evidence base;Exclusion;Financial Support;Flow Cytometry;Funding;gene environment interaction;Genetic;Glossary;Goals;Health behavior and outcomes;health communication;Hematopoiesis;Immunologic Monitoring;Immunology;implementation research;implementation science;improved;improved outcome;Individual;Infrastructure;innovation;interdisciplinary approach;Intervention;Investigation;irradiation;Justice;Life Style;lung cancer screening;Malignant Breast Neoplasm;Malignant neoplasm of thyroid;Malignant Neoplasms;member;method development;Methodology;Michigan;Mission;Modeling;molecular imaging;molecular pathology;Morbidity - disease rate;mortality;Names;novel;Outcome;Participant;patient oriented;Policies;Policy Research;Population;Population Sciences;pre-clinical;Prevention;Primary Prevention;Productivity;programs;Proteomics;Public Health;public policy on tobacco;Publications;Publishing;Quality of life;Registries;Research;Research Design;Research Support;Resource Sharing;Resources;Risk Reduction;Schools;Science;screening;screening guidelines;Secondary Prevention;Signal Transduction;single cell analysis;social structure;Strategic vision;Structure;Supportive care;synergism;tertiary prevention;Testing;thrombolysis;Tissue imaging;Tissues;tobacco control;tobacco exposure;Training;Training and Education;Transgenic Animals;translational impact;Translational Research;tumor microenvironment;United States;Universities;Woman;Work

PROJECT_TITLE: Cancer Control and Population Science (CCPS)


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Major depressive disorder (MDD), one of the most prevalent and disabling psychiatric disorders worldwide, may accelerate brain aging and increase risk for dementia. We propose a novel accelerated longitudinal in vivo positron emission tomography imaging study to determine the role of MDD in accelerating brain aging in later life, and evaluate the role of these changes in contributing to emotional dysregulation and cognitive dysfunction in this disorder. Given the aging of the general adult population and role of MDD as a risk factor for dementia, elucidation of molecular mechanisms underlying the link between MDD and accelerated brain aging is critical to identifying biomarkers of at-risk individuals, and informing novel targets for prevention and treatment.

PI_NAMEs: ESTERLIS, IRINA  (contact);PIETRZAK, ROBERT H

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Acceleration;Adult;Affect;Age;age acceleration;age related;age related changes;age related decline;Age Years;Age-associated memory impairment;aged;Aging;aging brain;aging process;aging related;Animals;Atrophic;Attention;Autopsy;Biological Markers;biomarker identification;Brain;Brain region;Chronic;Chronology;Clinical;Clinical Research;Cognition;cognitive function;cognitive process;Consensus;Data;Dementia;dementia risk;Dendritic Spines;density;Depressed mood;depressive symptoms;Development;Disabling;Disease;emotion dysregulation;endophenotype;Energy Metabolism;executive function;Glycoproteins;Growth;Hippocampus;Human;human old age (65+);imaging study;Impaired cognition;in vivo;Individual;insight;Interview;Laboratories;late life;Learning;Link;long term memory;longitudinal design;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Major Depressive Disorder;Measures;Mediating;Memory;Mental Depression;Mental disorders;Modeling;Molecular;Molecular Target;Morphology;neurochemistry;Neurons;Neuropsychology;Neurotransmitters;normal aging;novel;Phenotype;Population;Positron-Emission Tomography;postsynaptic;pre-clinical;preclinical study;Prefrontal Cortex;presynaptic;Prevention;Process;processing speed;Proteins;radioligand;receptor;Risk;Role;Sampling;Severities;Signaling Protein;Structure;Synapses;Synaptic plasticity;Synaptic Transmission;Synaptic Vesicles;synaptogenesis;targeted treatment;Technology;therapy design;trafficking;Vesicle;Work

PROJECT_TITLE: Depression and accelerated brain aging: A PET imaging study

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Significant geographic, racial, and gender disparities in HIV incidence exist in the United States, with Black cisgender women in the Southern U.S. having disproportionately high rates of HIV infection yet low rates of PrEP utilization. Through preliminary work, we have identified successful strategies to increase PrEP uptake and support PrEP persistence among Black cisgender women in community health clinic settings. Using the Exploration, Preparation, Implementation and Sustainment (EPIS) implementation science framework, this proposal will adapt these strategies for implementation and scale up in the Southern U.S. to improve PrEP care continuum outcomes among Black cisgender women.

PI_NAMEs: JOHNSON, AMY KRISTEN;RIDGWAY, JESSICA  (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Address;Adopted;AIDS prevention;Awareness;Black Populations;Black race;black women;cis-female;Clinic;Clinical;Community Health;Continuity of Patient Care;design;Disparity;Dissemination and Implementation;Education;effectiveness outcome;electronic medical record tool;Eligibility Determination;Epidemic;Evidence based intervention;Exploration, Preparation, Implementation, and Sustainment;gender disparity;geographic disparity;health care settings;High Risk Woman;HIV;HIV diagnosis;HIV Infections;HIV risk;hybrid type 2 design;implementation framework;implementation measures;implementation outcomes;implementation research;implementation science;implementation strategy;improved;Incidence;Individual;Inequity;Intervention;Knowledge;Measures;men;men who have sex with men;Midwestern United States;Neighborhood Health Center;Outcome;Patients;Phase;pre-exposure prophylaxis;Preparation;Prevention approach;primary care setting;Provider;racial disparity;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research Methodology;research study;Risk;satisfaction;scale up;Self Perception;Standardization;success;Training;transgender women;United States;uptake;Woman;women's diagnosis;women's outcomes;Work

PROJECT_TITLE: Implementation and Dissemination of Evidence-Based Interventions to Improve PrEP Care Continuum Outcomes Among Women in Community Health Clinics in the Southern U.S.


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Social Determinants of Health

PI_NAMEs: RESNICOW, KEN A. (contact)

PROJECT_TERMS: Address;Age;Alcohol consumption;Asian;Behavioral;Black race;Bladder;Breast;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer genetics;cancer health disparity;Cancer health equity;cancer risk;Catchment Area;cigarette smoking;Clinical;Clinical Research;clinical trial participant;Collaborations;Colon;colorectal cancer screening;Communities;community advisory board;community based research;community center;community collaboration;Community Developments;community engagement;Community Health Education;community intervention;Community Outreach;Country;Death Rate;Dedications;Disparity;Education;faculty support;Family Cancer History;Genetic;genetic testing;Goals;Health behavior;health disparity;health equity;Health equity research;health inequalities;Health Policy;Health Promotion and Education;Hispanic;improved;Incidence;Intervention;Liver;Lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;member;Mental Health;Michigan;Middle Eastern;Mission;mortality;Multiple Myeloma;Native American population;Native Americans;North African;Obesity;outreach;Patient Care;Patients;PF4 Gene;Physical activity;physical conditioning;Pilot Projects;Population;Prevention;prevention service;programs;Research;Research Support;Risk Factors;Risk Reduction;Role;rural Americans;Rural Population;Screening for cancer;Screening for Hepatocellular Cancer;screening services;service programs;Shapes;Strategic Planning;Tobacco use;Training;Underserved Population;Universities;Uterine Cancer;Work;working group

PROJECT_TITLE: Community Outreach and Engagement


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Epilepsy;Heart Disease;Neurodegenerative;Neurosciences;Pediatric;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Narrative Sudden unexplained death in epilepsy (SUDEP) is a major cause of morbidity in patients with seizures; however, the mechanisms of SUDEP remain largely unknown. We have identified a pathologic mutation in the Na/K-ATPase ATP1A3 which results in SUDEP through a predisposition to ventricular arrhythmias and propose leveraging human cardiac myocytes and mouse models to determine the mechanism of SUDEP. This approach represents a unique opportunity to dissect a key mechanism of SUDEP, gain insight into mechanisms of ventricular arrhythmias, and to explore the role of ATP1A3 in the heart more broadly.

PI_NAMEs: LANDSTROM, ANDREW P. (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: 3-Dimensional;Acceleration;Action Potentials;Acute;Affinity;Agonist;alternating hemiplegia;Arrhythmia;ATP1A3 gene;Binding;Biological Models;Bradycardia;Brain;Calcium;Calcium Signaling;Cardiac;Cardiac Myocytes;Cardiovascular Physiology;Catalytic Domain;Cause of Death;Cessation of life;Child;Childhood;chronotropic;clinical translation;comparison control;Complex;Development;Disease;Dysautonomias;Dystonia;Electrocardiogram;Electrophysiology (science);Epilepsy;Etiology;Exhibits;Experimental Models;extracellular;Generations;genetic variant;Goals;Health;Heart;Heart Abnormalities;Heart Rate;Homeostasis;Human;human induced pluripotent stem cells;human model;In Vitro;in vitro Model;in vivo;inhibitor;innovation;insight;K ATPase;Knock-in Mouse;Maps;Measurement;Measures;Mediating;Modeling;molecular drug target;Molecular Target;Monitor;Morbidity - disease rate;mouse model;Mus;Mutation;Myocardium;Na(+)-K(+)-Exchanging ATPase;Neurologic;novel;Optics;Ouabain;Outcome;Paralysed;patch clamp;Pathologic;Patients;pharmacologic;Pharmacotherapy;Predisposition;Prevalence;prevent;Prevention;Pump;Recording of previous events;Risk Factors;Role;Seizures;Site;Sudden Death;Telemetry;Testing;Time;Tissue Model;Tissues;uptake;Variant;Ventricular Arrhythmia;Ventricular Fibrillation

PROJECT_TITLE: Exploring the role of ATP1A3 mutations in sudden unexplained death in epilepsy

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Brain Disorders;Genetics;Human Genome;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Public Health Relevance Statement: Project Narrative Due to the lack of model systems, it has been difficult to study complex gene-environment interactions in Parkinson's disease. Using a combination of Drosophila genetics and patient-derived induced pluripotent stem cells, we can develop a model that can be utilized to identify and study the mechanisms of interaction among GWAS candidate genes, environmental factors, and α-synuclein. This K99/R00 proposal aims to characterize a novel interaction among LRRK2, rotenone, and α-synuclein, study the mechanism of the interaction and subsequently validate this novel multiplex system, which can be used to study these previously unknown interactions among environmental and genetic factors and is a step towards personalized medicine.

PI_NAMEs: SARKAR, SOUVARISH  (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Actin-Binding Protein;Actins;Adult;alpha synuclein;Automobile Driving;Autopsy;Binding Proteins;Biochemical;Biological Assay;Biological Models;Brain;Caffeine;Candidate Disease Gene;Cell model;Cells;Clinical;Complex;Data;Disease;disorder risk;dopaminergic neuron;Drosophila genus;Drug Targeting;druggable target;Environmental Risk Factor;Epidemiology;epidemiology study;Etiology;experimental study;Exposure to;fly;gene environment interaction;Gene Modified;Genes;Genetic;genetic risk factor;Genetic Screening;genome wide association study;Guanosine Triphosphate Phosphohydrolases;Human;Idiopathic Parkinson Disease;In Vitro;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;inhibitor;Laboratories;Lead;Link;LRRK2 gene;medical schools;Mel B;Mentors;Methods;mitochondrial dysfunction;Modeling;Molecular;mouse model;mutant;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neurotoxic;neurotoxicity;neurotoxicology;Neurotoxins;Nicotine;novel;overexpression;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;personalized medicine;Pesticides;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;Play;precision drugs;prevent;Protein Kinase;Proteomics;public health relevance;Risk;Risk Factors;Rodent Model;Role;Rotenone;Series;stem cell model;superresolution microscopy;symposium;synuclein;synucleinopathy;System;Techniques;therapeutic target;tool;Training;Tyrosine 3-Monooxygenase;Universities

PROJECT_TITLE: An in vivo multiplex model to study gene-environment interaction in Parkinson's Disease

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: ARLINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

ORG_STATE: TX

PHR: Project Narrative ALS is an incurable and fatal disease of progressive weakness, caused by the degeneration of muscle cells and the nerves controlling them. Enhancing muscle membrane repair can slow the progressive damage and loss of neuromuscular junctions (NMJs) – where nerve and muscle cells connect. This project combines multiple techniques to study and visualize the ongoing balance between membrane damage and repair mechanisms in muscle cells from ALS patients and mouse models, and uses these models to test whether a novel therapy to increase muscle membrane repair can slow ALS progression.

PI_NAMEs: MA, JIANJIE ;OSTROW, LYLE WILFRED;ZHOU, JINGSONG  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Ablation;Affect;ALS patients;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Antioxidants;Autophagocytosis;Autophagosome;Axon;Back;base;Benefits and Risks;Biochemical;Biology;Blood Circulation;Cardiolipins;Cell membrane;Cell Physiology;Cellular Structures;Clinical;Crossbreeding;Data;Defect;Disease;Disease Progression;Dose;Elements;Equilibrium;Extravasation;Feedback;Feeds;FRAP1 gene;functional decline;Functional disorder;Generations;Genetic;Goals;Half-Life;healthspan;Human;Imaging Device;improved;Injury;life span;live cell imaging;Lysosomes;Maintenance;Mediating;member;Membrane;Methods;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;mortality;Motor Cortex;Motor Neurons;mouse model;multicatalytic endopeptidase complex;Mus;Muscle;Muscle Cells;muscle degeneration;Muscle Fibers;Muscle Mitochondria;muscle repair;Muscular Atrophy;Nerve;nerve supply;Neuroglia;Neuromuscular Diseases;neuromuscular function;Neuromuscular Junction;neuron loss;Neurons;Normal tissue morphology;novel;novel therapeutics;Oxidative Stress;Oxidative Stress Induction;Pathologic;Pathology;Pathway interactions;pharmacologic;Physiology;preservation;Process;Progressive Disease;Protein Family;Proteins;Psoas Muscles;Quality Control;Reactive Oxygen Species;Recombinants;Regenerative capacity;regenerative tissue;Regimen;repair function;repaired;Research;Research Design;Respiratory Diaphragm;Respiratory Failure;Respiratory Muscles;Role;Safety;Sampling;Sarcolemma;Serum;Signal Transduction;Site;Skeletal Muscle;Stress;Support Groups;Symptoms;Systemic disease;Techniques;Testing;Therapeutic;Therapeutic Effect;tissue regeneration;tissue repair;Toxic effect;Transgenic Mice;Translating;TRIM Motif;ubiquitin-protein ligase;Visualization;Withdrawal

PROJECT_TITLE: Multifaceted role of MG53 in alleviating neuromuscular function decline in ALS


NIH_SPENDING_CATS: Cancer;Clinical Research;Prevention

PI_NAMEs: FEARON, ERIC R. (contact)

PROJECT_TERMS: Abbreviations;Address;Appointment;Area;Award;Behavioral;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;Cancer health equity;cancer immunotherapy;cancer initiation;cancer risk;cancer therapy;care delivery;career development;Catchment Area;Clinical;Clinical Research;Communities;community engagement;Community Outreach;Data Science;Development;Developmental Therapeutics Program;Education;Ensure;Epidemiology;Epigenetic Process;Equipment;equity, diversity, and inclusion;Faculty;Faculty Recruitment;Funding;Future Teacher;Glossary;Goals;health equity;Hematopoiesis;high risk;Immunology;improved;Infrastructure;innovation;Institution;interdisciplinary collaboration;Investments;Justice;Leadership;Malignant Neoplasms;member;Metabolism;metabolomics;Michigan;Names;new technology;outreach;Patient Care;Patient-Focused Outcomes;Persons;Pilot Projects;Population;Population Sciences;Program Development;programs;recruit;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;Resistance;Resource Allocation;Resource Sharing;Risk Factors;Risk Reduction;Services;Shapes;Signal Transduction;Strategic Planning;Systems Biology;therapy resistant;Training;Training and Education;Translational Research;tumor immunology;tumor microenvironment;Universities

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Cancer

PI_NAMEs: KELLER, EVAN T (contact)

PROJECT_TERMS: Accountability;Area;Awareness;Basic Science;Biology;Budgets;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;career;Cells;Clinical Research;Collaborations;Communication;Consultations;Contracts;cost effective;cost effectiveness;Data Analyses;Data Science;data sharing networks;Developmental Therapeutics Program;Engineering;Ensure;Epigenetic Process;epigenomics;Equipment;Evaluation;Feedback;Funding Mechanisms;Future;Glossary;Grant;Hematopoiesis;Image;Immunology;Individual;innovation;Institution;Interdisciplinary Study;Joints;Journals;Leadership;liquid biopsy;Malignant Neoplasms;medical schools;meetings;member;Mentors;Michigan;Mission;molecular imaging;Names;Newsletter;operation;Play;Population Research;Population Sciences;Positioning Attribute;pre-clinical;Productivity;programs;Proteomics Shared Resource;Publications;Quality Control;Research;Research Personnel;Resource Sharing;Resources;Role;S10 grant;Science;Services;Signal Transduction;skills;Source;Surveys;Technical Expertise;Technology;Training;Translational Research;tumor microenvironment;Universities;Work

PROJECT_TITLE: Shared Resource Management


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Many U.S. agencies are calling for interventions to prevent and reduce the large and persistent inequities in alcohol use for sexual and gender minority youth (SGMY)—but this goal cannot be achieved without additional evidence-based interventions. The goals of the proposed research are to conduct a randomized controlled trial to test a highly acceptable, theory-based, SGMY-informed, game-based intervention for preventing and reducing SGMY binge drinking. Given the dearth of evidence-based interventions for reducing alcohol use for SGMY, this project will provide novel scientific contributions that can help foster health equity for sexual and gender minority youth.

PI_NAMEs: COULTER, ROBERT W.S. (contact);EGAN, JAMES ERIN

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: active control;Affect;Alcohol consumption;alcohol risk;arm;Benchmarking;binge drinking;bullying;comparison group;Coping Skills;Data;demographics;design;Development;Devices;Discrimination;Distal;dosage;effectiveness/implementation trial;efficacy testing;efficacy trial;Empirical Research;Ethnic Origin;evidence base;Evidence based intervention;experience;Feedback;Fostering;Foundations;Frequencies;Future;gender minority youth;Goals;Grant;Health;health equity;help-seeking behavior;implementation intervention;Inequity;internalized stigma;Internet;Intervention;intervention delivery;intervention participants;Interview;Knowledge;Lesbian Gay Bisexual Transgender;Life Cycle Stages;media use;Methods;minority stress;minority stressor;Morbidity - disease rate;mortality;National Institute on Alcohol Abuse and Alcoholism;nonbinary;novel;Outcome;Participant;Persons;pilot test;Population;prevent;primary outcome;programs;Public Health;Race;Randomized, Controlled Trials;recruit;reduced alcohol use;Reporting;Research;Research Personnel;Research Project Grants;Risk Behaviors;Sampling;secondary outcome;Services;sexual minority youth;skills;social media;social stigma;Source;stressor;Subgroup;systematic review;Testing;theories;Time;Translating;treatment arm;Treatment Efficacy;Trust;underage drinking;United States National Institutes of Health;uptake;Victimization;web-accessible;Work

PROJECT_TITLE: A Randomized Controlled Trial of a Game-Based Intervention to Reduce Alcohol Use among Sexual and Gender Minority Youth

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PROJECT_TERMS: Abbreviations;Address;Advisory Committees;Age;anti-cancer research;anti-racism;Area;Award;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;cancer genetics;career development;Catchment Area;Clinical Research;Clinical Services;Clinical Trials Support Unit;Collaborations;Communication;Communities;community advisory board;community engagement;Community Outreach;Data;Data Science;Decision Making;demographics;Development;Developmental Therapeutics Program;Doctor of Philosophy;drug discovery;Education;empowerment;Ensure;equity, diversity, and inclusion;Ethnic Origin;Evaluation;experience;Faculty;Feedback;Frequencies;Funding;Future;Gender;Glossary;Goals;health equity;Health Sciences;Hematopoiesis;Immunology;Infrastructure;innovation;Institution;interdisciplinary collaboration;Justice;Last Name;Leadership;Malignant Neoplasms;Measures;medical schools;Medicine;meetings;member;Michigan;Mission;Monitor;NCI Center for Cancer Research;next generation;operation;Outcome;Outcome Measure;Patient Care;Peer Review;Policies;Population Sciences;Process;Program Development;programs;Provider;Publications;Race;Research;Research Personnel;Resource Allocation;Resource Sharing;Signal Transduction;skills;Strategic Planning;timeline;Training;Training and Education;Translational Research;tumor microenvironment;Universities;Vision

PROJECT_TITLE: Leadership Planning and Evaluation


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: CHAMPAIGN

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PROJECT NARRATIVE It has been over 50 years since the FDA approved a new class of drugs to treat infections caused by Gram-negative pathogens such as E. coli, K. pneumoniae, and A. baumannii, and as such there are now limited options for these infections. We have identified a very promising antibiotic candidate, called fabimycin, that has single-agent efficacy against these drug-resistant Gram-negative pathogens, is from a novel drug class, acts through a novel mechanism (inhibition of FabI), has a low frequency of resistance, has efficacy in challenging rodent infection models, and has no effect on commensal bacteria, suggesting the possibility that it could spare the gut microbiome. Herein we propose a comprehensive and systematic plan to develop novel versions of fabimycin where the Therapeutic Index is widened such that the lead can advance as a true translational candidate; such an antibiotic with single-agent efficacy against drug- resistant Gram-negative bacteria and that is gut-microbiome sparing would have an immediate impact on patients stricken with such infections.

PI_NAMEs: HERGENROTHER, PAUL  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acinetobacter baumannii;Acute;Acyl Carrier Protein;Amino Acids;Anti-Bacterial Agents;Antibiotics;bacterial resistance;Binding;Biological;Canis familiaris;Cell Culture Techniques;Clinic;Clinical;clinical candidate;Clinical Trials;Collaborations;Collection;commensal bacteria;Critical Pathways;Data;design;Development;Docking;Dose;drug development;Drug Kinetics;Drug resistance;efficacy study;Enzymes;Escherichia coli;Escherichia coli drug resistance;Evaluation;experience;experimental study;FDA approved;fighting;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;gut bacteria;gut dysbiosis;gut microbiome;in vivo;Industrialization;Infection;inhibitor;Investigational Therapies;Klebsiella pneumoniae;Knowledge;Laboratories;Lead;lead candidate;Ligands;Maximum Tolerated Dose;member;microbiome;microbiome research;Modeling;Multi-Drug Resistance;Mus;Nature;novel;novel drug class;novel strategies;Outcome;Oxidoreductase;pathogen;pathogenic bacteria;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Physicians;Pneumonia;preclinical study;Property;Proteins;Rattus;Resistance;resistance frequency;Rodent;Roentgen Rays;Safety;safety assessment;Scientist;Sepsis;Soft Tissue Infections;Structure;Structure-Activity Relationship;Therapeutic Index;Time;tool;Toxic effect;Toxicology;trait;Translations;Vertebral column;Work;Writing;X-Ray Crystallography

PROJECT_TITLE: FabI Inhibitors as Potent, Gut Microbiome-Sparing Antibiotics


NIH_SPENDING_CATS: Cancer;Patient Safety

ORG_CITY: ANN ARBOR

PI_NAMEs: SCHUETZE, SCOTT MICHAEL (contact)

PROJECT_TERMS: Address;Calendar;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;cancer genetics;Clinic;Clinical;Clinical Data;Clinical Protocols;Clinical Research;Clinical Trials;Clinical Trials Support Unit;dashboard;Data;data integrity;data management;Data Science;Development;Developmental Therapeutics Program;Discipline;Disease;Effectiveness;Ensure;Glossary;Health;Hematopoiesis;Immunology;Individual;Informatics;innovation;Institutional Review Boards;interest;Investigational Therapies;Leadership;life span;Link;Malignant Neoplasms;Medical;medical schools;Medicine;member;Mentors;Michigan;Minority;Minority Groups;Monitor;Names;Participant;participant safety;Pharmacy facility;Physician Executives;Policies;Population Sciences;Procedures;programs;Protocols documentation;quality assurance;Reporting;Research;Research Personnel;Resource Sharing;Resources;response;Review Committee;Safety;safety study;Science;Scientist;Services;Signal Transduction;sound;Specimen Handling;Standardization;System;timeline;tool;Training and Education;Translational Research;Translations;tumor;tumor microenvironment;Universities;Woman

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Disability Research;Hearing Loss

PHR: PROJECT NARRATIVE Deaf and hard of hearing (D/HH) persons are a linguistic and cultural minority group that is greatly underrepresented among biomedical scientists and academic faculty members. This program is a partnership between a research-intensive University (University of Rochester) and a teaching-intensive University (Rochester Institute of Technology) that is the 3rd largest producer of undergraduate STEM graduates among private universities in the U.S, and home to the world's first and largest technological college for the post- secondary education of D/HH persons (the National Technical Institute for the Deaf; NTID). This program will prepare D/HH postdoctoral Scholars for careers as academic faculty members, by developing and refining their skills in research, teaching and professionalism; by doing so, it will address the shortage of D/HH faculty in our academic workforce.

PI_NAMEs: BUCKLEY, GERARD J.;DEWHURST, STEPHEN  (contact);DYE, MATTHEW WILLIAM GEOFFREY

PROGRAM_OFFICER_NAME: BROWN, ANISSA F

PROJECT_TERMS: Achievement;Address;Appointment;Awareness;Biomedical Research;career;career development;Career Mobility;cohort;Communities;community building;deaf;Disparity;Educational process of instructing;Ensure;experience;Faculty;Goals;hard of hearing;higher education;innovation;Institution;inter-institutional;Knowledge;Leadership;Mentors;Mentorship;Outcome;Persons;Postdoctoral Fellow;Program Evaluation;programs;recruit;Research;Science;skills;Technology;Training;Universities

PROJECT_TITLE: IRACDA at Rochester Partnership to Advance Research and Academic Careers in Deaf Scholars

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


PI_NAMEs: CUNEO, KYLE C. (contact)

PROJECT_TERMS: Amendment;anti-cancer research;authority;Biometry;Calendar;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;cancer genetics;Cancer Intervention;career;Catchment Area;Charge;Clinic;Clinical Data;Clinical Investigator;Clinical Protocols;Clinical Research;Clinical Trials;Clinical Trials Support Unit;Data;data management;Developmental Therapeutics Program;Discipline;Disease;Ensure;Evaluation;expectation;experience;Glossary;Goals;Health;Hematopoiesis;Immunology;Industry;Informatics;Institution;Institutional Review Boards;Investigational Therapies;investigator-initiated trial;Leadership;Malignant Neoplasms;Medical;medical schools;medical specialties;member;Michigan;Minority;Mission;Monitor;Names;Participant;patient oriented research;Patients;Peer Review;Performance;Population Sciences;Principal Investigator;programs;Protocols documentation;Qualifying;quality assurance;Research;Resources;response;Rest;Review Committee;Role;Safety;Signal Transduction;Specimen Handling;success;System;Translational Research;tumor;tumor microenvironment;Underrepresented Populations;Universities

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: MORGANTOWN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE The innovative magnetic resonance imaging technologies and probes for multifunctional in vivo mapping of chemical parameters in tumor tissue microenvironment will be developed. Applications in a mouse model of breast cancer will provide new knowledge on stage-specific TME evolution during tumor progression, and will equip the professionals with a knowledge required to optimize TME-targeted anticancer therapies as well as provide scientific basis to evoke public awareness of high content of the phosphate-based modifiers in the processed food and the potential health risk.

PI_NAMEs: EUBANK, TIMOTHY D;KHRAMTSOV, VALERY V (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Acidity;Animal Cancer Model;Antitumor Drug Screening Assays;Area;Award;Awareness;Biochemical;Biological;Biological Process;biomaterial compatibility;Biophysics;Blood;Breast Cancer Model;cancer therapy;Characteristics;Chemicals;Clinical;Clinical Trials;Detection;Development;Diagnostic;Diagnostic Neoplasm Staging;disease model;Electron Spin Resonance Spectroscopy;Evolution;extracellular;Female;Food;Free Radicals;Functional Imaging;Funding;Future;Gene Expression;Genetic;Glutathione;Goals;Health;Human;Image;imaging modality;imaging probe;imaging study;Imaging Techniques;Imaging technology;improved;In Vitro;in vivo;innovation;inorganic phosphate;insight;interstitial;Knowledge;Learning;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;malignant phenotype;Mammary Neoplasms;Maps;Measurement;Metabolic;Methodology;Modality;Molecular;molecular imaging;Morphology;Mouse Mammary Tumor Virus;mouse model;Mus;Optical Methods;Oxidation-Reduction;Oxygen;Oxygen saturation measurement;Particulate;Penetration;Phenotype;Phosphorus;Physiologic pulse;Physiological;polyoma middle tumor antigen;pre-clinical;Process;Progress Reports;Property;Relaxation;Risk;Role;Scanning;Side;Signal Transduction;Site;Spectrum Analysis;Spin Labels;Spin Trapping;Staging;targeted treatment;Techniques;Technology;Testing;Therapeutic Intervention;therapy resistant;Time;Tissue imaging;tissue oxygenation;Tissue Sample;Tissues;tool;tumor;tumor microenvironment;tumor progression;Tumor Tissue;tumorigenesis;United States National Institutes of Health

PROJECT_TITLE: Profiling chemical tumor microenvironment: Application for diagnostics & therapy


NIH_SPENDING_CATS: Osteoporosis

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Narrative The vacuolar ATPases (V-ATPases) are large, multi-subunit proton pumps that are essential for many fundamental physiological processes in all eukaryotic organisms and malfunction of V-ATPases is associated with devastating human diseases including cancer, renal tubular acidosis, osteoporosis, diabetes, neurodegenerative diseases, and AIDS. Elucidating the structures and molecular mechanisms of V-ATPases assembly, biogenesis, regulation, and signaling will greatly advance our understanding of these V-ATPase-associated diseases. The completion of the project will not only advance our understanding on V-ATPases but also offer mechanistic insights to modulate human V- ATPase activity for disease treatment.

PI_NAMEs: FU, TIANMIN  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adenosine;ATP phosphohydrolase;Biochemical;Biogenesis;Biological Assay;Biophysics;Cells;Complement;Complex;Cryoelectron Microscopy;Diabetes Mellitus;Disease;Embryo;Endosomes;Eukaryotic Cell;experimental study;extracellular;Glycolipids;Golgi Apparatus;Human;human disease;Infection;innovation;insight;Lipids;Lysosomes;Malignant Neoplasms;Mammals;Mass Spectrum Analysis;Mediating;Membrane;Methods;microbial;Modeling;Molecular;Neurodegenerative Disorders;novel therapeutic intervention;Organelles;Organism;Osteoporosis;pH Homeostasis;Physiological Processes;Play;Polysaccharides;Proteins;Proton Pump;Protons;Regulation;Renal tubular acidosis;Resolution;Role;Sensorineural Hearing Loss;Signal Transduction;Structure;vacuolar H+-ATPase;Vesicle;Work;yeast genetics

PROJECT_TITLE: MOLECULAR MECHANISMS OF V-ATPASES: ASSEMBLY, BIOGENESIS, REGULATION, AND FUNCTION

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Lung;Lung Cancer;Precision Medicine

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: RELEVANCE: Only 1 in 5 lung cancer patients treated with immunotherapy (IO) has a favorable response. Additionally, the cost of IO is extremely high, >$200K/year per patient. The goal of this project is to develop novel computational radiomic tools which in conjunction with routine CT scans from IO clinical trials will allow for (1) identifying pre-IO therapy as to which non-small cell lung cancer patients could potentially benefit from immune checkpoint inhibitors and (2) quantitatively monitor serial changes in tumor heterogeneity during IO treatment for early identification of responders and non-responders.

PI_NAMEs: MADABHUSHI, ANANT  (contact);VELCHETI, VAMSIDHAR

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Adoption;Aftercare;anti-PD-1;anti-PD-1/PD-L1;anti-PD-L1;Antitumor Response;Biological;Biological Markers;Biopsy;Cancer Patient;Characteristics;Clinical;Clinical Trials;Clinical Trials Cooperative Group;Computer Vision Systems;Computers;cost;Development;Diagnosis;Disease Progression;Early identification;Early treatment;Eastern Cooperative Oncology Group;Environment;Goals;imaging biomarker;Immune;Immune checkpoint inhibitor;Immune response;Immune system;immune- related response criteria;Immuno-Chemotherapy;Immunotherapeutic agent;Immunotherapy;immunotherapy clinical trials;immunotherapy trials;industry partner;Inflammatory;inhibitor therapy;Institution;Letters;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Molecular;Monitor;Morphology;Mutation;Nature;Neoadjuvant Therapy;Nivolumab;Nodule;non-invasive imaging;Non-Small-Cell Lung Carcinoma;novel;Outcome;Pathologic;Pathway interactions;Patient Selection;Patients;Pattern;PD-1/PD-L1;Pharmaceutical Preparations;Pharmacologic Substance;Phase;phase III trial;Phenotype;predicting response;predictive marker;Predictive Value;primary endpoint;prognostic;prognostic of survival;prognostic value;prognostication;programmed cell death ligand 1;prospective;Publishing;radiological imaging;Radiology Specialty;radiomics;Reporting;Resected;responders and non-responders;response;Scanning;Shapes;Site;success;survival outcome;Testing;Texture;Time;Tissues;tool;Toxic effect;Training;Treatment outcome;treatment response;tumor;tumor behavior;Tumor Biology;tumor heterogeneity;Tumor-Infiltrating Lymphocytes;Validation;X-Ray Computed Tomography

PROJECT_TITLE: Novel Radiomics for Predicting Response to Immunotherapy for Lung Cancer


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Cardiovascular disease remains the major cause of death in the US. Through the renewal and expansion of this highly successful postdoctoral training program, we align ourselves with the stated goal of the NHLBI to “provide a sustained flow of qualified physician-scientists able to think critically and translate findings freely between the basic and clinical spheres.” We will accomplish this goal through strong mentorship by established experts in the field, specialized didactics, and intensive training through basic, translational and/or clinical research projects tackling the major forms of cardiovascular disease.

PI_NAMEs: FISHMAN, GLENN I (contact);GOLDBERG, IRA J

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TITLE: Training Program in Cardiometabolic Diseases

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Cancer;Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: BALADANDAYUTHAPANI, VEERABHADRAN  (contact)

PROJECT_TERMS: analytical tool;anti-cancer research;Applications Grants;Area;Basic Science;Bioinformatics;Biometry;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;Cancer Research Project;Cancer Science;Clinical;Clinical Informatics;Clinical Protocols;Clinical Research;Clinical Research Protocols;Clinical Sciences;Clinical Trials;cohort;Collaborations;Computer software;Computerized Medical Record;computerized tools;Consultations;Continuing Education;Data Analyses;Data Science;Database Management Systems;design;Development;Developmental Therapeutics Program;Drops;Educational workshop;Faculty;Glossary;Grant;Hematopoiesis;Hour;Human Resources;Immunology;improved;Infrastructure;innovation;lectures;Malignant Neoplasms;member;Mentorship;Methods;Michigan;Mission;Monitor;Names;Observational Study;Population;Population Sciences;Prevention Research;programs;Protocols documentation;Publications;Reproducibility;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Scientist;Services;Signal Transduction;symposium;Training;Training and Education;training opportunity;Translational Research;tumor microenvironment;Universities;Validation;webinar

PROJECT_TITLE: Cancer Data Science (CDS)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


PI_NAMEs: WALTER, NILS G (contact)

PROJECT_TERMS: Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;Cells;cellular imaging;Clinical Research;cost effective;Dedications;Developmental Therapeutics Program;Electron Microscopy;Equipment;experience;Glossary;Hematopoiesis;Human Resources;Image;Image Analysis;imaging modality;imaging scientist;Imaging technology;Immunoelectron Microscopy;Immunology;Institution;instrument;instrumentation;Ions;Lasers;Light;light microscopy;Lighting;Malignant Neoplasms;member;Michigan;Microscopy;Morphology;multi-photon;Names;Population Sciences;Preparation;programs;Publications;Research;Research Personnel;Resource Sharing;Resources;Sampling;Scanning;Scanning Electron Microscopy;Services;Signal Transduction;Stains;Structure;Techniques;theories;Time;Tissue imaging;Tissues;Training;Translational Research;Transmission Electron Microscopy;tumor microenvironment;Universities

PROJECT_TITLE: Cell and Tissue Imaging (CTI)


NIH_SPENDING_CATS: Genetics

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Acetyl-transfer reactions play an important regulatory function in the vast majority of the human proteome, RNAome and metabolome, and aberrant acetyl-transfer reaction function is correlated with human disease. Despite the importance of acetyl-transfer reactions, mechanistic information regarding their distinct modes of regulation are poorly understood. In this proposal, we will address the molecular mechanisms of how how protein and RNA acetyltransferases target their cognate substrates, how auxiliary proteins and ribosome association contribute to certain acetyl-transfer reactions, how acetyl-CoA metabolism link to chromatin regulation and fatty acid synthesis, and how we can leverage mechanistic and structural information to develop potent and selective acetyl-transfer reaction inhibitors for therapy.

PI_NAMEs: MARMORSTEIN, RONEN  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Acetate-CoA Ligase;Acetyl Coenzyme A;Acetylation;Acetyltransferase;amino group;Anabolism;ATP Citrate (pro-S)-Lyase;base;Biological;Biology;Cardiovascular Diseases;Cholesterol;Chromatin;cofactor;Cytidine;Enzymes;Family member;Fatty Acids;Fatty-acid synthase;genetic regulatory protein;histone acetyltransferase;Histones;Human;human disease;inhibitor;inhibitor therapy;isoprenoid;Life;Link;Lysine;Malignant Neoplasms;Mediating;Metabolic;Metabolism;metabolome;Modification;Molecular;N-terminal;Nerve Degeneration;Organism;Pathway interactions;pharmacologic;Play;Positioning Attribute;Protein Acetylation;Protein Complex Subunit;Proteins;Proteome;rare genetic disorder;Reaction;Regulation;Ribosomes;RNA;Role;Side;Stimulus;Substrate Specificity;Syndrome;targeted agent;targeted treatment;Tertiary Protein Structure

PROJECT_TITLE: Molecular Mechanisms, Pathways and Inhibition of Acetyl-Transfer Reactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


PI_NAMEs: MORGAN, MEREDITH A (contact)

PROJECT_TERMS: Animals;Area;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;Cell Line;Clinical;Clinical Research;Collaborations;Consultations;Developmental Therapeutics Program;Doctor of Philosophy;dosage;Dose;dosimetry;Ensure;Equipment;experience;experimental study;Fostering;Funding;Glossary;Hematopoiesis;image guided;Immunology;innovation;interest;irradiation;Irradiation Shared Resource;Knowledge;Malignant Neoplasms;Medical;member;Michigan;Modeling;Multimodal Imaging;Mus;Names;Normal Cell;Physics;Population Sciences;programs;Radiation;radiation delivery;Radiation therapy;Radiobiology;Rattus;Research;Research Design;Research Personnel;Research Project Grants;research study;Resources;Services;Signal Transduction;System;Technology;Time;Tissues;tool;Training;Translational Research;Treatment Protocols;tumor microenvironment;Universities

PROJECT_TITLE: Experimental Irradiation (EI)


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: MOORE, THOMAS A. (contact)

PROJECT_TERMS: assay development;Biochemistry;Biological Markers;Biological Sciences;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;cell preparation;Cell Separation;Cellular biology;Clinical Research;Computer software;Consultations;cost effective;cost efficient;Cytometry;data acquisition;Dedications;Developmental Therapeutics Program;Discipline;Education;experience;Experimental Designs;Faculty;Flow Cytometry;Flow Cytometry Shared Resource;Funding;Genetic;Glossary;Goals;Hematopoiesis;Human Resources;Immunology;Individual;instrument;instrumentation;Investments;Leadership;Malignant Neoplasms;Measures;member;Michigan;Names;operation;Pharmacology;Population Sciences;Process;programs;Recording of previous events;Research;Research Personnel;Resource Sharing;service utilization;Services;Signal Transduction;Sorting;Specialist;Techniques;Technology;Time;Training;Translational Research;tumor microenvironment;Universities

PROJECT_TITLE: Flow Cytometry (FLOW)


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Prevention

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative The proposed study addresses a key NIH priority, strengthening care for people living with HIV at high risk of treatment failure, and will be one of the first studies to use an innovative framework, MOST, to focus on the HIV care cascade in a high-burden, resource-strained setting (South Africa). To do so, the study will employ a fractional factorial design to determine the effects of five intervention components on the primary outcome (HIV viral suppression) and secondary outcomes, assess cost and other implementation features of each component, and then construct an optimized intervention package, with no inactive or poorly performing components.

PI_NAMEs: ORRELL, CATHERINE ;SABIN, LORA L (contact)

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: Address;Adherence;Agreement;antiretroviral therapy;Behavioral;care systems;Caring;Cessation of life;Client;Clinic;Clinical;clinical care;clinical practice;Communities;Competence;compliance behavior;Continuity of Patient Care;cost;Cost Analysis;cost effective;cost effectiveness;Data;Data Collection;design;Detection;effective intervention;Effectiveness;electronic adherence monitoring;Electronics;Elements;Engineering;Ensure;Epidemic;Evaluation;evidence base;Evidence based intervention;falls;follow-up;Future;Goals;Health;high risk;HIV;improved;Individual;innovation;Intervention;Interview;Measures;Mediator;Methods;Modeling;Monitor;Motivation;motivational enhancement therapy;multi-component intervention;multiphase optimization strategy;novel;Outcome;outreach;Participant;Patient Compliance;Patients;Peer Group;Persons;Pharmacy facility;Phase;Pilot Projects;Policy Maker;practical application;Preparation;primary outcome;Process;Proctor framework;programs;Public Health;Quality of Care;Randomized;Records;recruit;Research;research clinical testing;Research Design;Resource-limited setting;Resources;Risk Reduction;Sampling;secondary outcome;Self Determination;Services;South Africa;success;Support Groups;Surveys;Techniques;Technology;Testing;theories;Time;Time and Motion Studies;transmission process;treatment adherence;Treatment Failure;Treatment outcome;treatment risk;United States National Institutes of Health;Viral;Virus

PROJECT_TITLE: Supporting Sustained HIVTreatment Adherence after Initiation (SUSTAIN)

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care

PI_NAMEs: AN, LAWRENCE CHIN-I (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;anti-cancer research;artist;Award;Behavioral;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;cancer health disparity;Catchment Area;Clinical Research;Clinical Trials;Communication;Communication Programs;community engagement;community partners;Consultations;COVID-19 pandemic effects;Decision Making;design;Development;Developmental Therapeutics Program;Evaluation;evidence base;Family member;Glossary;Grant;health communication;Health Sciences;Hematopoiesis;Immunology;improved;Individual;innovation;Intervention;Maintenance;Malignant Neoplasms;medically underserved population;member;Michigan;Names;open source;patient oriented;Patients;Population Sciences;precision oncology;Preparation;programs;prototype;Publications;Research;Research Design;Research Personnel;Resource Sharing;Resources;Science;Scientist;Screening for cancer;Services;Signal Transduction;software systems;Support System;symptom management;System;Technology;Translational Research;Treatment-Related Cancer;tumor microenvironment;Universities;Work

PROJECT_TITLE: Health Communications (HC)


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Hematology;Lung;Orphan Drug;Rare Diseases

ORG_CITY: RICHMOND

ORG_NAME: ILLEXCOR THERAPEUTICS, LLC

ORG_STATE: VA

PHR: Acute Respiratory Distress Syndrome (ARDS) is a life-threatening condition that can result in acute respiratory failure and severe hypoxemia due to a significant impairment of gas exchange. ARDS affects approximately 200,000 individuals annually in the US, and, despite medical advances in the understanding of protective ventilation strategies and modern life support techniques, leads to nearly 75,000 deaths, with an unacceptably high mortality rate that has not improved in two decades. Following discovery of the potent water-soluble allosteric modifier VZHE-039.glycine HCl, which can rapidly increase the capacity of hemoglobin to bind and transport oxygen in a dose-dependent manner, we propose a definitive efficacy study to evaluate the potential of our novel drug to improve clinically-meaningful outcomes for ARDS patients to support advancement into a human clinical trial.

PI_NAMEs: LIGHT, DAVID RICHARD (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Acute respiratory failure;Affect;Affinity;Aldehydes;American;Amines;analog;Animal Model;Animals;Binding;Blood gas;Bolus Infusion;Bronchoscopes;Cardiac Death;Cessation of life;Clinical;Clinical Trials;Continuous Infusion;cost;COVID-19 pandemic;Critical Care;Critical Illness;Death Rate;Development;Dissociation;Dose;efficacy study;Endotoxins;Event;Exposure to;Extracorporeal Membrane Oxygenation;Family suidae;Gases;Glycine;Goals;Heart;Heart Arrest;hemodynamics;Hemoglobin;Histopathology;Hour;Human;Hypoxemia;Hypoxia;Impairment;improved;in vivo;indexing;Individual;Infusion procedures;Injury;innovation;intravenous administration;Intravenous Bolus;Intravenous infusion procedures;Kidney;Laboratories;Left;Length of Stay;Life;Liver;Lobe;Lung;lung injury;lung lobe;Maintenance;Measures;Mechanical ventilation;Mechanics;Medical;Modeling;Modernization;Monitor;Morbidity - disease rate;mortality;mortality risk;N-terminal;Natural Compound;Neurologic;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Organ failure;Outcome;Oxygen;oxygen transport;Parents;Partial Pressure;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Phase;phase 1 study;Pimonidazole;Placebo Control;prevent;primary outcome;Protocols documentation;Randomized;Refractory;Reproducibility;Respiration;respiratory;Respiratory Failure;Safety;scale up;Schiff Bases;Severities;small molecule;Sodium Chloride;Stains;Supportive care;Survivors;Techniques;tertiary care;Therapeutic;therapeutic candidate;Tissue Fixation;Tissues;Titrations;Validation;Valine;vanillin;ventilation;Water;Whole Blood

PROJECT_TITLE: Novel therapeutic approach for severe ARDS with a potent pharmacologic allosteric hemoglobin modifier

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IVBH-V(10)]


PI_NAMEs: CASTRO, MARIA G (contact)

PROJECT_TERMS: adaptive immunity;Basic Science;Biological Assay;Biological Models;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;cancer initiation;cancer therapy;Cancer Vaccines;Clinical Research;Clinical Sciences;cost effective;cytokine;Cytometry;Data;Development;Developmental Therapeutics Program;Ensure;Enzyme-Linked Immunosorbent Assay;Equipment;Fostering;Funding;Future;Glossary;Goals;graft vs host disease;Health Services Research;Hematopoiesis;Image;Immune;Immune response;immunogenic;Immunologic Monitoring;Immunology;immunomodulatory therapies;Immunotherapy;Inflammatory Response;Investigation;Knowledge;Laboratories;Leadership;Malignant Neoplasms;member;Michigan;Microbe;Monitor;Names;Natural Immunity;Nature;Neoplasm Metastasis;Oncogenic;Pathway interactions;Patients;Population Sciences;Procedures;programs;Publications;Quality Control;Regulation;Research;Research Personnel;Research Support;Resource Sharing;Role;Sampling;Services;Signal Transduction;Stains;Standardization;Suspensions;Technology;therapy resistant;Translational Research;Treatment Efficacy;tumor microenvironment;Universities

PROJECT_TITLE: Immunologic Monitoring (IM)


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Much remains unknown about the rate and dynamics of human somatic mutations, which are known drivers of cancer and are hypothesized to play a role in aging. This proposal aims to determine the rate and significance of somatic mutations in the human genome and their relationship to disease outcomes.

PI_NAMEs: STEELY, CODY  (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Age;Aging;Algorithmic Software;Algorithms;Blood;Body mass index;Cancer Etiology;Cancer Patient;Cardiovascular Diseases;career;career development;Cells;Collection;computational pipelines;Copy Number Polymorphism;Data;Data Set;design;Detection;Disease;Disease Outcome;DNA;DNA Repair;Elements;Event;experience;experimental study;Family;Foundations;Frequencies;Generations;genetic pedigree;Genetic Polymorphism;Genome;genome sequencing;Germ Cells;Germ Lines;Germ-Line Mutation;Goals;Hematopoiesis;Human;Human Genome;human tissue;improved;Individual;Malignant Neoplasms;Measures;Mediating;member;Modeling;Mutation;Organoids;Phenotype;phenotypic data;Play;Postdoctoral Fellow;Process;programs;Research;Role;Sampling;Series;Short Tandem Repeat;Single Nucleotide Polymorphism;Somatic Mutation;Testing;Time;time use;Tissues;Training;Universities;Utah;Variant;variant detection;whole genome;Work

PROJECT_TITLE: Analysis of Somatic Mutations in Longitudinal Whole-genome Sequencing Data