NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Emergency Care;Health Services;Physical Injury - Accidents and Adverse Effects

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Non-compliance with clinical practice guidelines compromises patient outcomes after injury, and is particularly prevalent among the elderly. One of the critical barriers to reducing preventable deaths after injury is the absence of methods to identify the source of physician non-compliance and to personalize the selection of implementation strategies. The objective of this proposal is to develop and to validate a serious game (an applied video game) to understand physician behavior in trauma triage.

PI_NAMEs: MOHAN, DEEPIKA  (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Address;Adherence;adverse outcome;Assessment tool;Behavior;Behavior assessment;behavior change;Behavioral;behavioral phenotyping;Budgets;burnout;Calibration;care costs;Clinical;clinical implementation;Clinical Practice Guideline;cognitive load;contextual factors;cost;Development;effective intervention;Effectiveness;Elderly;Emergency Department Physician;Emergency department visit;Equilibrium;Fostering;Future;game development;Guidelines;Hospitalization;human old age (65+);implementation strategy;improved;Incidence;injured;Injury;Intervention;Interview;Laboratories;Licensing;Measurement;Measures;Methods;mortality;multidisciplinary;non-compliance;novel;older adult;older patient;Outcome;Pain;Paper;Patient Triage;Patient-Focused Outcomes;Patients;Performance;personalized approach;Physicians;Play;pressure;preventable death;Process;programs;Property;prototype;provider behavior;Quality of life;Radar;recruit;Research;Resources;Respondent;Sampling;severe injury;Signal Detection Analysis;social norm;Source;Structure;Surveys;Testing;Time;tool;Trauma;trauma centers;Trauma patient;Triage;Uncertainty;user centered design;Variant;Video Games;virtual reality simulation;wasting;Work;World War II

PROJECT_TITLE: Development of a serious game to measure physician implementation of trauma triage guidelines

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Orphan Drug;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MADISON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on understanding how a class of drugs called PARP inhibitors, drugs being used to treat cancer and being tested for an expanding number of non- malignant human diseases, cause the serious blood and bone marrow toxicities seen in some patients taking them. This proposal will provide key mechanistic insight into which cells in the bone marrow require the enzymes targeted by these drugs for normal functioning, and whether these drugs have the capability to mutate the DNA of these cells to predispose patients to bone marrow failure or blood cancers. Thus, the proposed research is relevant to the National Heart, Blood, and Lung Institute’s mission to promote the prevention of blood diseases and enhance the health of all individuals so that they can live longer and more fulfilling lives.

PI_NAMEs: CHURPEK, JANE ELLEN (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Address;Adverse effects;Antineoplastic Agents;Apoptosis;Blood;Blood Cells;Bone Marrow;Bone Marrow Cells;Bone marrow failure;BRCA1 gene;BRCA2 gene;cancer risk;cancer type;Cell Communication;Cell Cycle;Cell Proliferation;Cells;Clinical;Clinical Trials;Clone Cells;competitive environment;cytopenia;cytotoxicity;Data;Databases;design;Disadvantaged;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA replication fork;Drug Targeting;Drug usage;ds-DNA;Environment;Enzymes;Etiology;experience;Exposure to;fitness;Food and Drug Administration Drug Approval;Fostering;Genes;Genetic Variation;Genotype;Germ Lines;Goals;Health;Hematological Disease;Hematopoiesis;Hematopoietic Neoplasms;Hematopoietic stem cells;homologous recombination;homologous recombination deficiency;Human;human disease;Human Genetics;Impairment;improved;In Vitro;in vivo;in vivo Model;Individual;Induced Mutation;inhibitor;innovation;insight;Lesion;leukemia;Malignant Bone Marrow Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;medication safety;Methods;Mission;mouse model;Mus;Mutagenesis;Mutate;Mutation;National Heart, Lung, and Blood Institute;neoplastic cell;new therapeutic target;Non-Malignant;Normal Cell;Pathway interactions;Patients;Pharmaceutical Preparations;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;precision medicine;preclinical study;Predisposition;prevent;Prevention;Prevention strategy;Production;progenitor;Public Health;repaired;Research;Risk;Safety;Sampling;Single Strand Break Repair;stem;stem cell exhaustion;stem cell function;stem cell population;stem cell proliferation;stem cells;stressor;success;Supporting Cell;Testing;therapy development;Time;Toxic effect;TP53 gene;Transplantation

PROJECT_TITLE: Mechanisms of Parp inhibitor-induced bone marrow toxicities

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: The ventromedial prefrontal cortex is generally believed to mediate the inhibition of fear, however it is also paradoxically activated in a large subset of post-traumatic stress disorder patients, where fear expression is greatly enhanced. The proposed work will investigate the mechanisms underlying fear encoding in the ventromedial prefrontal cortex. Overall, results will reveal new information regarding how the medial prefrontal cortex participates in the encoding and expression of learned fear with important implications for disorders of pathological fear and anxiety.

PI_NAMEs: CUMMINGS, KIRSTIE ALYSSA (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Amygdaloid structure;Anatomy;Anterior;Anxiety;Anxiety Disorders;Area;Behavior;Behavior Therapy;Behavioral;Brain region;calcium indicator;cell type;conditioned fear;Data;Development;Disease;Dorsal;Electrophysiology (science);Ensure;Exhibits;experience;experimental study;Extinction;fear memory;Fiber;Freezing;Fright;Head;Human;in vivo;in vivo calcium imaging;Individual;Injury;Insula of Reil;Joints;Knowledge;Learning;Link;Measurement;Medial;Mediating;Memory;Mentors;Microscope;Modeling;Monitor;Mus;Neurons;nonhuman primate;optogenetics;Pathologic;Pathological anxiety;Patients;Phase;Photometry;Physiological;Play;Population;Post-Traumatic Stress Disorders;Prefrontal Cortex;Productivity;recruit;Regulation;Research;Research Personnel;Resistance;Risk Factors;Rodent;Role;skill acquisition;Structure;Synapses;Testing;Training;traumatic event;Work

PROJECT_TITLE: Ventromedial Prefrontal Cortex Regulation of Fear Memory

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STONY BROOK

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: NARRATIVE Both Alzheimer's disease and normal aging are associated with a dramatic decrease in the production of new neurons in the hippocampus and this decrease may underlie the associated cognitive impairments. Slowing or even reversing this decrease may be important for addressing the cognitive decline due to old age or disease. We have recently developed a new approach for studying the birth of new neurons from stem cells, and we will now apply this approach to determine the trajectory of neurogenesis while it is compromised by aging and Alzheimer's disease.

PI_NAMEs: ENIKOLOPOV, GRIGORI N (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Acceleration;Address;Adult;adult neurogenesis;Adverse effects;Aging;aging brain;aging related;aging related disease;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid beta-Protein;Animal Model;Animals;Anticonvulsants;Bar Codes;Birth;Brain;Brain Diseases;Cell Differentiation process;Cells;Clonal Expansion;Clonality;Cognitive;cognitive function;cohort;combinatorial;Complement;Complex;Development;Disease;DNA;Drug usage;Excitatory Amino Acid Antagonists;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic Recombination;Goals;Hippocampus;Human;human old age (65+);Impaired cognition;Impairment;Individual;instrument;Knowledge;Label;Levetiracetam;Life Cycle Stages;life span;Link;Maintenance;Malignant - descriptor;mature animal;Memantine;Methods;Modality;Modeling;Monoclonal Antibodies;mouse genome;mouse model;Mus;nerve stem cell;neurodevelopment;neurogenesis;Neurons;normal aging;novel strategies;Outcome;Pharmaceutical Preparations;Physical activity;Production;Proliferating;Regulation;Reporter;Resolution;RNA;Running;Scheme;Series;single cell analysis;stem cell division;stem cell exhaustion;stem cells;System;Techniques;Tissues;tool;transcriptome;transcriptomics

PROJECT_TITLE: Endogenous barcoding to determine complex dynamics of adult neurogenesis in aging and Alzheimer's disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Mental Health;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: SURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Only 13% of adults living with end-stage renal disease (ESRD) have normal cognitive function. Black ESRD patients are uniquely vulnerable to premature cognitive aging; systemic racism (i.e., structural, institutional, and interpersonal racism) is a likely cause of health disparities in cognitive impairment, cognitive decline, and Alzheimer's Disease and Related Dementia (AD/ADRD). In collaboration with The National Kidney Foundation, Alzheimer's Association, and a local community advisory board, we seek to address key priorities for the National Institute on Aging among ESRD patients in the national registry (n=1.36 million) and an ongoing, NIA- funded, multi-center, prospective cohort study (n=5,275): 1) to estimate the impact of structural and institutional racism on incident AD/ADRD; 2) to quantify the contributions of lifecourse systemic racism on cognitive impairment and decline; 3) to test whether resilience to systemic racism protects against cognitive impairment and decline.

PI_NAMEs: MCADAMS DEMARCO, MARA A. (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Accounting;Address;Adult;Age;aged;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Award;Behavioral;Biological;black patient;Black race;Chronic Disease;Cognition;Cognitive aging;cognitive function;Cohort Studies;Collaborations;Communities;community advisory board;community engagement;comorbidity;Compensation;Data;Data Set;Databases;demographics;design;Diagnosis;Dialysis procedure;Discrimination;Disparity;End stage renal failure;Enrollment;experience;Faith;Family;Foundations;Functional dependence;Funding;Glean;Goals;Health Disparities Research;health disparity;health equity;Impaired cognition;Individual;Institution;Institutional Racism;instrument;Intervention;Kidney;Life Cycle Stages;life span;lifetime risk;Link;Measurement;Measures;Mediation;Medicare;Mental Health;Methods;Modeling;National Institute on Aging;older adult;Outcome;Participant;Patient Self-Report;Patients;perceived stress;Phase;Policies;Population;premature;prevent;promote resilience;Prospective, cohort study;Race;racial difference;racism;Registries;resilience;Risk;Source;Structural Racism;Survival Analysis;Testing

PROJECT_TITLE: Structural Racism, Resilience, and Premature Cognitive Aging in End-stage Renal Disease


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: GALVESTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: This study extends an existing national longitudinal study of aging and health in Mexico, with two additional waves of core data collection and one more wave of its ancillary study on cognitive aging, The resulting public use databases will extend over twenty-six years. Highly comparable to similar studies in the U.S. and other countries, the study will allow enhanced research on aging, Alzheimer's disease and related dementias, health, and mortality in a rapidly aging developing country with limited institutional support for the elderly, and with long-lived health, economic, and social ties to the U.S.

PI_NAMEs: WONG, REBECA  (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Address;Adult;aged;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Ancillary Study;bilingualism;Blood;Cognitive;Cognitive aging;cognitive function;Cohort Analysis;Collaborations;Communities;Country;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Collection;data enclave;data platform;Databases;design;Developing Countries;Dimensions;Discrimination;DNA Methylation;Documentation;Economics;Elderly;empowerment;Environmental Risk Factor;Epigenetic Process;Equity;experience;Family;family support;follow-up;Fostering;Funding;Genetic;Geography;Geriatrics;Goals;Health;Health and Retirement Study;Health behavior;health care availability;Health Technology;Healthcare;human old age (65+);improved;Income;Individual;Inequity;Institution;instrument;Interdisciplinary Study;Knowledge;Language;Latin America;Lead;Length;Life Cycle Stages;Link;Longitudinal Studies;Mental Health;Mexican;Mexico;migration;mobile computing;mortality;older adult;outreach;Participant;Peer Review;perceived discrimination;physical conditioning;Physical Function;Population;population based;Positioning Attribute;preservation;programs;Protocols documentation;Research;Research Personnel;Research Support;response;Retirement;Running;Rural;rural area;Saliva;saliva sample;Sampling;social;Social Protection;Spanish/English;statistics;Structure;Surveys;trend;United States;United States National Institutes of Health;usability;user-friendly;Venous;virtual;web platform;web site;Work

PROJECT_TITLE: The Mexican Health Aging Study (MHAS)

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative We propose the first and largest multi-ethnic study to investigate the association between per- and poly- fluoroalkyl substances (PFAS) and breast cancer risk using innovative laboratory technologies and statistical methods and integrate the comprehensive information on PFAS, PFAS-associated metabolic alterations, genetics, and breast cancer risk factors to identify subgroups of women at increased risk for breast cancer. Results from this study can potentially identify women who may be particularly susceptible to breast cancer and provide critical information to inform PFAS regulatory guidelines.

PI_NAMEs: LEE, EUNJUNG  (contact)

PROGRAM_OFFICER_NAME: MAHABIR, SOMDAT

PROJECT_TERMS: Accounting;Address;Adult;African American;Age;amino acid metabolism;animal data;Animals;Area;Asian;Asian Americans;Blood;Blood specimen;Breast Cancer Patient;Breast Cancer Prevention;Breast Cancer Risk Factor;California;cancer epidemiology;Cancer Etiology;Cancer Patient;cancer risk;Carcinogens;Cessation of life;Chemicals;cohort;Communities;consumer product;Data;data integration;Development;Diagnosis;Diagnostic;Disparity;diverse data;Endocrine disruption;Endocrine Disruptors;Environmental Epidemiology;epidemiologic data;Epidemiology;epidemiology study;ethnic diversity;ethnic minority;Ethnic Minority Women;Ethnic Origin;Ethnic Population;European;Fasting;Female;follow-up;Genetic;Genetic Predisposition to Disease;Genomics;Geographic Distribution;Glucose;Goals;Guidelines;Hawaii;Hispanic Women;Hormones;Hour;Incidence;Individual;Industrialization;innovation;insight;International;Investigation;Japanese American;laboratory equipment;Latina;Latino;Life Style;Link;Lipids;Liquid Chromatography;Low income;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mass Spectrum Analysis;Measurement;Measures;Metabolic;Metabolic Pathway;metabolome;metabolomics;multi-ethnic;multidisciplinary;Native Hawaiian;neoplasm registry;Nested Case-Control Study;Not Hispanic or Latino;novel;Participant;Pathway interactions;Plasma;Policies;Poly-fluoroalkyl substances;polygenic risk score;Population;Population Heterogeneity;precision medicine;Predisposition;Pregnancy;prenatal exposure;Process;Property;prospective;Prospective cohort;Prospective Studies;Race;racial diversity;racial minority;racial population;Research;Research Personnel;Resolution;Risk;Risk Factors;Role;Sample Size;Sampling;Source;Statistical Methods;Subgroup;Testing;White Women;Woman

PROJECT_TITLE: A nested case-control study of perfluoroalkyl and polyfluoroalkyl substances (PFAS) and breast cancer risk in the Multiethnic Cohort

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: TROY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

PHR: Project Narrative Microneedle patches (MNP) are an emerging technology for painless, low-dose, prolonged drug delivery. Polymerized drugs, i.e. poly(pro-drug)s, are a unique class of macromolecules composed almost entirely of a pro-drug molecule in long chain repeating sequences. In this application, we propose to develop the first ever MNP composed of a poly(pro-drug), specifically crosslinked thermosetting polyester resins of pro-17β-estradiol for prolonged low-dose estrogen delivery.

PI_NAMEs: PALERMO, EDMUND FRANCIS (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Alkenes;Applications Grants;Biocompatible Materials;Biological Availability;biomaterial compatibility;birth control;Body Temperature;Buffers;Chemistry;Clinical;clinical application;controlled release;crosslink;Curcumin;Dermal;Development;Dexamethasone;Dose;Drug Compounding;Drug Delivery Systems;drug release kinetics;elastomeric;Elastomers;Emerging Technologies;Engineering;Estradiol;Estrogens;Exhibits;fabrication;Failure;female sex hormone;Fibroblasts;flexibility;Foundations;functional group;Future;gabapentin;Gel Chromatography;Glass;Goals;Hepatic;Human;Hydrolysis;Hydrophobicity;hypodermic needle;Hypogonadism;Immersion;implantation;In Vitro;Individual;Injections;innovation;Kinetics;Laboratories;Length;Libraries;liquid chromatography mass spectroscopy;macromolecule;Malignant Neoplasms;mechanical properties;Mechanics;Menopause;Methods;minimally invasive;Molds;monomer;nanoindentation;nanomolar;Needles;new technology;Oral Administration;Organic solvent product;Pain;Painless;Patient Compliance;Penetration;perfluoropolyether;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Physiological;Plant Resins;Polyesters;polymerization;Polymers;pre-clinical;Probucol;Procedures;Prodrugs;Property;Puncture procedure;Recovery of Function;Reproducibility;Resistance;Resveratrol;Rodent Model;safety assessment;Sampling;scaffold;Scanning Electron Microscopy;Scheme;Site;Skin;skin irritation;Skin Temperature;Solvents;Spinal cord injury;Stratum corneum;Stress;Sulfhydryl Compounds;Technology;Temperature;Time;transgender;Transition Temperature;Work

PROJECT_TITLE: Poly(pro-Estrogen) Microneedle Patches


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SAN DIEGO

ORG_NAME: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO

PHR: Project Narrative The newest approach to treating diabetic kidney disease is to reduce physical and metabolic stress on the kidney by inhibiting the renal glucose transporter, SGLT2. This research is dedicated to gaps in knowledge about the mechanisms whereby inhibitors of SGLT2 and of other glucose transporters reduce physical and metabolic stress on the kidney and whether these mechanisms might be leveraged to improve outcomes in non- diabetic chronic kidney disease. This research uses rat and mouse models of human diabetes and chronic kidney disease because key variables can be measured in these models that cannot be measured in vitro or in human subjects.

PI_NAMEs: THOMSON, SCOTT CULVER (contact);VALLON, VOLKER

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: absorption;Acid-Base Equilibrium;Acute;ADORA2A gene;Amino Acids;Angiotensins;Animal Model;Aristolochic Acids;arteriole;Attention;base;Behavior;Biochemistry;Biological Markers;blood pressure reduction;Cells;Chronic;Chronic Kidney Failure;Clinical;constriction;Dedications;Deterioration;Diabetes Mellitus;diabetic;Diabetic Nephropathy;diabetic patient;Diameter;Distal;drug action;energy balance;Event;Exposure to;fatty acid metabolism;Feedback;Filtration;Genetic Models;Glomerular Capillary;glomerular filtration;glomerular function;Gluconeogenesis;Glucose;Glucose Transporter;Goals;Grant;Growth;Health;Heart;Histologic;Human;human data;human model;human subject;improved;improved outcome;In Vitro;inhibitor;Injury;Injury to Kidney;insight;Juxtaglomerular Apparatus;Kidney;Kidney Diseases;kidney metabolism;Knowledge;Limb structure;Macula densa;Maps;Measures;Mediating;Metabolic;Metabolic stress;metabolomics;Micropuncture;Microscopic;Modeling;mouse model;Mus;Nephrectomy;Nephrons;new therapeutic target;NHE1;Nitric Oxide Synthase Type I;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;NOS1 gene;novel;novel therapeutic intervention;novel therapeutics;Nutrient;Outcome;Oxygen;Pathway interactions;Patients;Perfusion;Persons;Pharmaceutical Preparations;Physiology;preservation;pressure;Proteinuria;proteomic signature;Proteomics;Rattus;Regional Perfusion;Relaxation;Renin;Reporter;Research;Research Methodology;Research Personnel;response;Rodent;Sampling;Signal Transduction;Sodium;sodium-hydrogen exchanger 2;Streptozocin;Streptozocin Diabetes;Stress;stress reduction;Surface;symporter;System;Techniques;Testing;Therapeutic;Translating;Tubular formation;Urine;Visualization

PROJECT_TITLE: Glomerular and Tubular Function in the Diabetic Kidney

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-W(91)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_NAME: NDRI-USA, INC.

PHR: Public Health Relevance Statement/Project Narrative Understanding the role of the pharmaceutical industry in propelling the current opioid crisis in the U.S. is an essential strategy for preventing future epidemics. Using various forms of textual data and analytic methods, this project examines the specific impacts of industry efforts to target military veterans as opioid consumers and the ways that the industry attempts to popularize new narratives, or scripts, about opioid analgesics within veteran-specific periodicals. The identification of dominant narratives and their circulation through veterans' media outlets represents a critical case study in pharmaceutical industry efforts to change prescribing policy and popular culture. Findings will be translated into deliverables which positively impact pain management policy, practice, and the attitudes and expectations of our nation's veterans and others struggling with chronic pain.

PI_NAMEs: ELLIOTT, LUTHER ;HADDOCK, CHRISTOPHER KEITH (contact)

PROGRAM_OFFICER_NAME: HAEGERICH, TAMARA

PROJECT_TERMS: Addendum;Advocacy;analytical method;Anxiety Disorders;Archives;Area;Attitude;Automobile Driving;Back;Benzodiazepines;Black race;Caring;Case Study;Cessation of life;chronic pain;chronic pain management;chronic pain patient;Circulation;Clinical;Cognitive;County;Data;data mining;Data Set;Development;Disadvantaged;Disparity;Documentation;Dose;Drug Controls;Drug Industry;Ethnic Origin;expectation;experience;Formulation;Fostering;future epidemic;Health;Healthcare Systems;Hepatitis C;Heroin;heroin use;high risk population;HIV/HCV;hospital care;Hospitals;Industry;Injections;injured;Injury;innovation;insight;Intervention;Interview;Journals;Label;large datasets;Leadership;Legal;Literature;Litigation;Lived experience;Low income;Manufacturer;Marketing;Medical;member;Methodology;Methods;Military Personnel;military veteran;Minority;Morbidity - disease rate;mortality;Natural History;Newspapers;non-opioid analgesic;online resource;Opioid;Opioid Analgesics;opioid epidemic;opioid mortality;opioid therapy;opioid use;Outcome;Overdose;overdose death;Pain;Pain management;pain patient;Patients;Perception;Periodicals;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Policies;Policy Maker;Population;prescription opioid;Prevalence;prevent;Process;Public Health;public health priorities;public health relevance;Publications;Publishing;Race;racial disparity;Recording of previous events;Research;Research Methodology;Research Personnel;resilience;Resources;Risk;Role;Scholarship;Scientist;service organization;service providers;Shapes;Sleep Disorders;social;social culture;social stigma;Technology;text searching;Tobacco;tobacco control;Tobacco Industry;tool;Translating;translational framework;Translational Research;trend;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;web site;Withdrawal

PROJECT_TITLE: The Impact of Pharmaceutical Industry Messaging on the Opioid Crisis among U.S. Military Veterans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Public Health Relevance – Obesity occurs when fat tissue expands and adversely affects health. Obesity is a leading cause of type 2 diabetes, non-alcoholic fatty liver disease and dyslipidemia. Interactions between immune and fat cells and how they regulate lipid balance is important in understanding how obesity contributes to these disorders. Defining immune-fat cell interactions offer the possibility of developing therapeutic strategies to combat obesity-associated diseases.

PI_NAMEs: FERRANTE, ANTHONY W (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Acute;adipocyte differentiation;Adipocytes;Adipose tissue;Affect;Asthma;Atherosclerosis;Autoimmune Diseases;Bacterial Infections;Biology;bone;Bone Marrow;Bone Marrow Cells;calcium phosphate;Calories;Carbohydrates;Catabolism;Categories;Cell Communication;Cells;Chemotaxis;Chemotaxis Induction;combat;Dementia;Deposition;Disease;Dyslipidemias;Equilibrium;Esterification;exosome;extracellular vesicles;Fatty acid glycerol esters;Fatty Acids;Functional disorder;Funding;Glycerides;Glycerol;Grant;Health;Homeostasis;Hydrolysis;Immune;Immune system;Impairment;Individual;Infection;Inflammatory;Insulin;Insulin Resistance;Link;Lipase;lipid biosynthesis;lipid metabolism;Lipids;Lipolysis;Macrophage;Malignant Neoplasms;Mammals;Metabolic;Metabolism;Modeling;monocyte;Mutant Strains Mice;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;Obesity;Obesity associated disease;Pathway interactions;Phenotype;Predisposition;Production;programs;Proliferating;Property;public health relevance;Publishing;recruit;Regulation;response;Risk;Signal Transduction;Source;Structure;Testing;Therapeutic;Tissue Expansion;Tissues;Triglycerides;uptake;vesicular release;Virus Diseases

PROJECT_TITLE: Adipose Tissue Macrophage Phenotype and Function

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Narrative: Research scientists focused on the fields of pregnancy and reproduction are critically important in the advancement of national public health. Nonetheless, the increasing complexity of such research across clinical and non-clinical specialties means there may not be enough future cross-trained scientists to meet our health needs. We propose a partnership of the Faculty of the Integrated Program in Endocrinology with Clinical Fellowships in the depts ObGyn, Pediatrics and Medicine, in conjunction with outstanding Campus Research Centers and Cores to provide an excellent environment to train these future scientists in translational research, and we propose here a training program plan to achieve that goal.

PI_NAMEs: BIRD, IAN M. (contact);LEVINE, JON E

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TITLE: Integrated Program in Endocrinology Translational Postdoctoral Training Program


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE USP27X is a deubiquitinating enzyme (DUB) whose functions are required for tumor growth, and higher expression of this DUB correlates with poor survival of cancer patients. The proposed studies will determine how this DUB fosters tumor growth and will illuminate new avenues for therapeutic intervention in cancer.

PI_NAMEs: ATANASSOV, BOYKO S (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Ablation;Acceleration;Affect;Alleles;Antibody-drug conjugates;Biochemical;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;cancer cell;Cancer cell line;Cancer Model;Cancer Patient;cancer survival;CDK4 gene;cell growth;Cell Line;Cell Proliferation;Cells;Clinical;clinically relevant;CRISPR/Cas technology;Cyclin D1;Data;Dedications;Deubiquitinating Enzyme;Deubiquitination;Development;Drug resistance;Drug Targeting;druggable target;Engineering;Enzymes;Epidermal Growth Factor Receptor;ERBB2 gene;Family;Fostering;Gene Expression Regulation;genetic approach;Genetic Transcription;Hand;HER2 inhibition;Histones;Human;improved;in vivo;inducible Cre;inhibitor;insight;LoxP-flanked allele;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;member;Molecular;Molecular Analysis;mouse model;Mus;neoplastic cell;novel;overexpression;Pathway interactions;patient prognosis;Patients;Phenotype;Process;Proteins;Recurrence;Regulation;Resistance;resistance mechanism;response;Role;small hairpin RNA;Tamoxifen;targeted agent;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;therapy resistant;Trastuzumab;treatment response;tumor;Tumor Escape;tumor growth;tumor xenograft;tumorigenesis;Tumorigenicity;Tyrosine Kinase Inhibitor;Ubiquitin;ubiquitin isopeptidase;ubiquitin-specific protease;Work;Xenograft Model

PROJECT_TITLE: The role of USP27X-Cyclin D1 axis in HER2 Therapy Resistant Breast Cancer

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Aging;Cancer;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Hodgkin's Disease;Lung;Lung Cancer;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Radiation Oncology;Rare Diseases;Rehabilitation

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE This study will develop and validate novel cardiovascular disease risk prediction models that incorporate cardiac substructure doses. By translating this work to the clinic, we can optimize radiotherapy planning for newly diagnosed children and recommend risk profile-based counseling for survivors of childhood cancers.

PI_NAMEs: HOWELL, REBECCA MAUREEN (contact);MULROONEY, DANIEL A.;YASUI, YUTAKA

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: Accounting;Address;adolescent patient;Adult;Adult Hodgkin's Lymphoma;Aftercare;Age;Anthracycline;Arrhythmia;Cancer Patient;Cancer Survivor;cancer therapy;Cardiac;Cardiomyopathies;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;care providers;Caring;Case/Control Studies;Cause of Death;Cessation of life;chemotherapy;Chest;Child;Childhood;childhood cancer survivor;Childhood Cancer Survivor Study;Chronic;Clinic;Clinical;clinical care;clinical practice;Clinical Trials;cohort;Cohort Studies;Collaborations;Communities;Coronary Arteriosclerosis;Coronary artery;Counseling;Data;Data Reporting;demographics;Diabetes Mellitus;Disease Outcome;Dose;Event;evidence base;Foundations;Future;Goals;Health;Heart;Heart Atrium;Heart failure;Heart Valve Diseases;Heterogeneity;Hodgkin Lymphoma survivors;Hypertension;in silico;Institution;Investigation;Left ventricular structure;Life;Long-Term Survivors;Malignant neoplasm of lung;Malignant Neoplasms;Methods;Modality;Modeling;modifiable risk;Morbidity - disease rate;mortality;Newly Diagnosed;novel;Obesity;Organ;Outcome;Patient Self-Report;Patients;Pediatric Oncology;personalized medicine;personalized risk prediction;Population;predictive modeling;premature;Premature Mortality;prospective;Radiation;Radiation therapy;Radiation Tolerance;Recommendation;reconstruction;Reporting;response;Risk;Risk Assessment;Risk Factors;risk mitigation;risk prediction;risk prediction model;Risk Reduction;Saint Jude Children's Research Hospital;Smoking;Survival Rate;Survivors;survivorship;System;tool;Translating;treatment optimization;treatment planning;Ventricular;web app;Work

PROJECT_TITLE: Personalized Risk Prediction to Reduce Cardiovascular Disease in Childhood Cancer Survivors


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Through the UCLA High Throughput Neuropsychiatric Disease Phenotyping Center, a highly collaborative group of investigators will identify potential convergent and distinct mechanisms by which risk genes act using highly parallel quantitative analyses in human stem cell models of brain development and function.

PI_NAMEs: GESCHWIND, DANIEL H (contact);NOVITCH, BENNETT G

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: 3-Dimensional;Address;Alleles;Anatomy;Architecture;Astrocytes;autism spectrum disorder;Biological;Biological Assay;Biological Testing;Brain;Calcium;Cell Line;Cell Survival;cell type;Cells;Cerebrum;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Communities;Core Facility;Coupled;CRISPR/Cas technology;Custom;Data;data sharing;Defect;density;Development;Developmental Delay Disorders;Dideoxy Chain Termination DNA Sequencing;Disease;Disease Pathway;disease phenotype;disorder risk;engineered stem cells;Essential Genes;excitatory neuron;Female;Gene Expression;gene function;Genes;Genetic Heterogeneity;genetic manipulation;genetic risk factor;Genetic study;Genome engineering;high dimensionality;Human;human disease;human embryonic stem cell;Human Genetics;human induced pluripotent stem cells;human model;human pluripotent stem cell;human stem cells;Image;In Vitro;in vivo;induced pluripotent stem cell;inhibitory neuron;Intellectual functioning disability;Knock-out;knockout gene;Link;male;Measures;Methods;model organism;Modeling;Molecular;molecular phenotype;Morphology;multimodality;Mutation;nerve stem cell;Nervous System;neural;neurite growth;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;neuronal cell body;Neurons;Neurophysiology - biologic function;neuropsychiatric disorder;novel;Nuclear RNA;null mutation;Optics;Organoids;Pathway interactions;Phenotype;phenotypic data;Physiological;Process;Production;Proteins;Reproducibility;Research Personnel;Resolution;Resource Sharing;risk variant;Role;Schizophrenia;screening;sensor;sex;single nucleus RNA-sequencing;single-cell RNA sequencing;small hairpin RNA;Small Nuclear RNA;stem cell differentiation;stem cell model;stem cell proliferation;stem cells;Synapses;System;Testing;three dimensional cell culture;three-dimensional modeling;Time;transcriptome sequencing;voltage

PROJECT_TITLE: UCLA High-Throughput Neuropsychiatric Disorder Phenotyping Center (UCLA HT-NPC)


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Immunotherapy;Infectious Diseases;Inflammatory Bowel Disease;Microbiome

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Narrative The intestines are home to a community of bacteria, but also of viruses and fungi. Fungal microbiota is usually studied trough methodologies exploring the fungal DNA imprint and then the functional characteristics of these fungi are explored using model fungal organisms that are not the one present in the patients. Using fungi from the intestines of inflammatory bowel disease patients, that we discovered to be functionally different across different individuals, we will study the process on inflammation where these organisms might influence response to therapy.

PI_NAMEs: ILIEV, ILIYAN DIMITROV (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: acrosome stabilizing factor;Affect;anti-fungal agents;Antibody Repertoire;Bacteria;Candida;Candida albicans;Categories;cell injury;Cells;Characteristics;Chronic;Clinical;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;Colitis;Collection;Colon;Communities;Controlled Clinical Trials;Data;Disease;Distal;Event;Evolution;fecal transplantation;Fungal DNA;Fungal Genome;fungal microbiota;fungus;Gene Modified;Genetic;Genetic Polymorphism;Genome;genome sequencing;genome wide association study;Grant;gut colonization;gut inflammation;Home;Human;IL1R1 gene;Immune;immune activation;Immune response;Immunity;immunomodulatory therapies;imprint;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Integration Host Factors;Interleukin-1;Interleukin-1 beta;Interleukin-10;Intestinal Diseases;intestinal homeostasis;Intestines;Laboratories;Lead;Light;Maps;Mediating;Methodology;Modeling;Mononuclear;mouse model;Mucous Membrane;murine colitis;Mus;new therapeutic target;novel;Organism;Pathogenicity;Pathway interactions;Patients;Phagocytes;Phenotype;Placebo Control;Play;prednisolone;Process;Production;Property;Regulation;Research;Resolution;response;Role;Severity of illness;Shapes;Symbiosis;T-Lymphocyte;Therapeutic;Therapeutic Intervention;TNF gene;Treatment Efficacy;treatment response;Ulcerative Colitis;Virulence;Virulence Factors;Virus;Work

PROJECT_TITLE: Commensal fungal communities in the regulation of immunity and intestinal inflammation

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Cystic Fibrosis;Lung;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: IOWA CITY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative: Cystic Fibrosis (CF) is the most common life-threatening autosomal-recessive condition among Caucasians, with clinical care for patients in the U.S. alone totaling over $450 million annually. Although airway submucosal glands are severely affected in this disease, little is known about the biology of this glandular stem cell niche or how CF airway disease impacts function of this stem cell compartment. The proposed research will utilize mouse and ferret models to dissect the basic biology of glandular stem cells and disease-associated changes in CF that may be important to stem cell-directed therapies for this disease.

PI_NAMEs: ENGELHARDT, JOHN F (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Acute;Address;Adult;Affect;Airway Disease;airway epithelium;airway regeneration;airway repair;Asthma;autosome;Basal Cell;Behavior;Biology;cartilaginous;Caucasians;Cell Compartmentation;Cell Lineage;Cell Maintenance;Cell Maturation;Cell surface;cell type;Cells;Chronic;Chronic Bronchitis;Chronic lung disease;Chronic Phase;chronic respiratory disease;clinical care;conditional knockout;Cre driver;Cystic Fibrosis;cystic fibrosis airway;Data;design;Developmental Biology;Disease;Disease Progression;Duct (organ) structure;Ductal Epithelial Cell;Epithelial Cells;epithelial repair;Family suidae;Ferrets;Functional disorder;Funding;Genes;Genetic Models;Gland;Glandular Cell;Goals;Grant;Homeostasis;Human;Human Biology;human model;injured airway;Injury;insight;Knowledge;Label;Life;Lobar;Lung;Maintenance;Mammals;Maps;migration;Modeling;mouse model;Mus;Myoepithelial cell;Natural regeneration;novel;Outcome;Pathogenesis;Pathologic;Patient Care;Phase;Phenotype;pressure;Process;progenitor;Proliferating;Property;Pulmonary Cystic Fibrosis;Recording of previous events;regenerative;repaired;Reporter;Repression;Research;Reserve Stem Cell;Signal Transduction;Site;stem cell biology;stem cell function;stem cell niche;stem cells;Stress;Submucosa;Surface;System;Testing;tool;Trachea;transcription factor;Transgenic Organisms;Translating;VX-770;WNT Signaling Pathway;Work

PROJECT_TITLE: Biology of Submucosal Gland Stem Cells in the Airway

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Hematology;Infectious Diseases;Lung;Orphan Drug;Pneumonia;Pneumonia and Influenza;Precision Medicine;Rare Diseases;Sepsis

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: The proposed ARDS, Pneumonia, and Sepsis (APS) Phenotyping Consortium Coordinating Center, CAPSTONE, will be a highly functional and integrated coordination and support infrastructure that will raise the quality and scientific rigor of the research conducted by the APS Phenotyping Consortium. The team, composed of leading content experts at Vanderbilt, Johns Hopkins, and University of California San Francisco, will simultaneously harmonize the needs of varied stakeholders; guide design, analysis, and data collection; and keep ahead of technical, societal, and medical evolutions. CAPSTONE will expand foundational work on APS phenotyping, identify gaps, and help create statistical and other methods for redefining critical illness syndromes with the ultimate goal of improving and personalizing management strategies that will curtail the devastating morbidity and mortality caused by APS.

PI_NAMEs: BERNARD, GORDON RAPHAEL;LINDSELL, CHRISTOPHER J.;SELF, WESLEY H (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Adherence;Attenuated;Big Data;biobank;Biological;Biometry;California;career development;Caring;Classification;Clinical;clinical center;Clinical Research;Clinical Trials Data Monitoring Committees;Cognitive;cohort;Communication;Communities;community engagement;Compensation;Complex;Contracts;Critical Illness;Data;Data Collection;data infrastructure;data management;data modeling;data quality;Dedications;design;Development;efficacious treatment;electronic consent;Electronic Health Record;Enrollment;Ensure;Evolution;experience;Failure;Foundations;Goals;Grouping;Heterogeneity;Image;improved;Individual;individual patient;Infrastructure;innovation;Investigation;Knowledge;knowledge base;Leadership;Manuals;Measurement;Measures;Medical;Methods;Mission;Monitor;Morbidity - disease rate;mortality;multimodality;novel therapeutics;operation;Operations Research;Outcome;Participant;patient population;patient subsets;Patients;performance site;personalized management;Pharmacotherapy;Phenotype;phenotyping algorithm;Pneumonia;point of care;Population;precision medicine;Precision therapeutics;Process;profiles in patients;prognostic;protocol development;Protocols documentation;Recovery;recruit;Reporting;Reproducibility;Research;Research Design;Research Infrastructure;Risk Factors;San Francisco;Science;Security;Sepsis;Site;skill acquisition;skills;Standardization;Statistical Data Interpretation;success;Syndrome;synergism;targeted treatment;Therapeutic;Training;Training Support;Translating;Translational Research;treatment response;Trust;Universities;virtual;Work

PROJECT_TITLE: Coordination for ARDS, Pneumonia, and Sepsis supporting Training, Organization and Network Efficiency (CAPSTONE)


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Rural Health;Social Determinants of Health

ORG_CITY: POTSDAM

ORG_NAME: CLARKSON UNIVERSITY

PHR: BOREALIS - Narrative The BiOengineering Research Education to AcceLerate Innovation in STEM (BOREALIS) research education program is designed to advance the diversity of the bioengineering research workforce by creating a pathway to bioengineering graduate study for regional, sociodemographically diverse students. Diversity in the research workforce enhances the quality of research and the provision of health care, and promotes innovation and growth—attributes essential for the public’s health and to sustain our nation’s preeminence in science.

PI_NAMEs: RICHARDS, MELISSA CAROLE (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: academic preparation;Academy;Acceleration;Address;Atmosphere;Bachelor's Degree;Basic Science;Biological Sciences;Biomedical Engineering;Biomedical Research;Black, Indigenous, People of Color;bridge program;career;cohesion;cohort;college;Communication;Communities;Country;County;Curiosities;Depressed mood;design;Development;disabled students;disadvantaged student;economic disparity;Education;education planning;education research;Educational Curriculum;Eligibility Determination;Engineering;Enrollment;Environment;Equity;evidence base;experience;Face;Faculty;Fostering;Future Generations;Goals;graduate school;Growth;Healthcare;high school;higher education;Home;Household;improved;Income;Indian reservation;innovation;Institution;instructor;interest;intersectionality;Investments;Leadership;Learning;Mentors;Mind;Minor;Native American Tribe;New York;Participant;Pathway interactions;pedagogy;peer;Performance;Positioning Attribute;Preparation;programs;Public Health;Readiness;recruit;Reporting;Research;Resources;role model;Rural;Scholars Program;Science;Series;skills;Social Development;sociodemographics;STEM field;STEM research;student participation;Students;success;summer research;Teacher Professional Development;Technology;Time;Training;Training Programs;tribal Nation;undergraduate student;Universities;Work;Workplace


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: CENTER OVERVIEW PROJECT NARRATIVE The University of Colorado Denver (UC Denver) is renowned for its basic, translational and clinical diabetes research programs, which encompass Type 1 and Type 2 diabetes, diabetes complications and autoimmunity. The purpose of the UC Denver Diabetes Research Center (DRC) is to unite this community and facilitate their research endeavors by providing efficient and innovative shared resources, developing enrichment programs to facilitate interactions and collaborations between center members, and implementing a strong pilot and feasibility program to bring new investigators into the diabetes field. These efforts will result in improved understanding of disease etiologies and progression, and promote the development of diabetes treatments and cures.

PI_NAMEs: SUSSEL, LORI  (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Area;Autoimmunity;base;Biomedical Research;Budgets;career;career development;Cell Culture Techniques;Cells;Clinical;Clinical Skills;Collaborations;Colorado;Communication;Communities;Complex;Complications of Diabetes Mellitus;cost;Data;Databases;design;Development;Diabetes Mellitus;diabetes mellitus therapy;Direct Costs;Disease;Doctor of Philosophy;Education;Environment;Etiology;Faculty;Flow Cytometry;Fostering;Genes;Goals;Grant;Growth;Histology;Hospitals;Human;human stem cell-derived;Immunologics;improved;In Vitro;Individual;Infrastructure;innovation;Institution;instrumentation;Insulin-Dependent Diabetes Mellitus;islet;Knowledge;Medical;medical schools;member;Mentors;Microscopy;Modeling;Non-Insulin-Dependent Diabetes Mellitus;novel;operation;Organoids;Participant;Patients;Pediatric Hospitals;Prevention;Productivity;programs;Reagent;recruit;Research;Research Personnel;Resource Sharing;Resources;Rodent;Sampling;Scientist;Series;Services;synergism;Technology;tissue processing;Tissue Procurements;Tissues;Training;Translations;type I and type II diabetes;United States National Institutes of Health;Universities;University Hospitals

PROJECT_TITLE: UC Denver Diabetes Research Center


NIH_SPENDING_CATS: Diabetes

PROJECT_TERMS: Accounting;base;Budgets;career;career development;Colorado;Communication;Communities;Complement;Consultations;cost;cost effective;Data;Databases;Destinations;Diabetes Mellitus;Effectiveness;Ensure;Environment;Exposure to;Faculty;Faculty Recruitment;Feasibility Studies;Feedback;Fostering;Goals;Individual;instrumentation;Intention;interest;Investments;Leadership;Mediation;Medical;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Patients;Pilot Projects;Positioning Attribute;Prevention;Price;Process;Productivity;Program Development;programs;Reagent;Research;Research Personnel;Resource Sharing;Resources;Scientist;screening;Services;Students;System;Technology;Training;United States National Institutes of Health;Universities;Utilization Review;web site;Work

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Clinical Research;Diabetes;Pediatric

PI_NAMEs: REWERS, MARIAN J (contact)

PROJECT_TERMS: Acceleration;Adolescent;Adult;Age;analytical tool;Area;Autoantibodies;Autoimmunity;Basic Science;bench-to-bedside translation;Beta Cell;biobank;Bioinformatics;Biological;Biological Assay;Biostatistical Methods;Blood specimen;Cardiovascular Diseases;Cells;Center for Translational Science Activities;Child;Childhood diabetes;Clinic;Clinical;clinical care;clinical center;Clinical Data;Clinical Research;clinical translation;Collaborations;Colorado;Communication;Complications of Diabetes Mellitus;Computerized Medical Record;Core Facility;cystic fibrosis related diabetes;Data;Data Management Resources;data warehouse;Databases;Development;diabetes control;Diabetes Mellitus;diabetes risk;diabetic;Diabetic Nephropathy;Diagnostic;Disease;Economic Burden;eligible participant;Equipment;Faculty;Faculty Recruitment;Fostering;Functional disorder;Funding;genetic analysis;Gestational Diabetes;Goals;Grant;Growth;Health;Hospitals;human leukocyte antigen testing;Human Resources;Hyperglycemia;Improve Access;improved;Incidence;Individual;Infant;Infrastructure;Institution;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;interest;Laboratories;life span;Longitudinal Studies;Medical;Medical center;Mentored Clinical Scientist Development Program;Metabolic dysfunction;metabolic phenotype;Molecular Analysis;Morbidity - disease rate;mortality;Mothers;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Participant;Patient Recruitments;patient registry;Patients;Pediatric Hospitals;peripheral blood;Persons;Phenotype;Physicians;Plasma;Population;prevent;Process;Productivity;programs;Protocols documentation;recruit;Registries;repository;Research;Research Design;research facility;Research Infrastructure;Research Personnel;Resource Sharing;Resources;sample collection;Sampling;Scientist;segregation;Serum;Services;skills;Statistical Data Interpretation;Talents;Teacher Professional Development;Techniques;Technology;Testing;Tissue Banks;Tissue Sample;Training;Translational Research;type I and type II diabetes;United States Department of Veterans Affairs;United States National Institutes of Health;Universities

PROJECT_TITLE: Clinical Resource Core


PI_NAMEs: NAKAYAMA, MAKI  (contact)

PROJECT_TERMS: Adipocytes;Agreement;Alberta province;Antibodies;Antigens;base;Basic Science;biobank;Blood specimen;cell bank;Cell Line;cell repository;Cells;Clinical;Collaborations;Colorado;Communities;Complement;Consultations;Diabetes Mellitus;disease model;Drug or chemical Tissue Distribution;Equipment;Formalin;Freezing;Funding;Generations;Histologic;Histology;Histopathology;Human;human pluripotent stem cell;human tissue;Immune;Individual;innovation;Institutional Review Boards;instrument;International;islet;Letters;liquid crystal polymer;Maintenance;material transfer agreement;member;Mission;Non-Insulin-Dependent Diabetes Mellitus;Operative Surgical Procedures;Organoids;Pancreas;Paraffin Embedding;Paraffin Tissue;Pathogenesis;Pathology;Patients;Preparation;Procedures;Protocols documentation;Reagent;Research;Research Personnel;Resources;Rodent;Sampling;Services;Source;Spleen;Stains;Surveys;Thymus Gland;Tissue Embedding;tissue preparation;tissue processing;Tissue Procurements;Tissue Sample;Tissues;Training;Universities;Work

PROJECT_TITLE: Tissue Procurement and Processing Core


NIH_SPENDING_CATS: Bioengineering;Diabetes

PI_NAMEs: BENNINGER, RICHARD KP (contact)

PROJECT_TERMS: antibody libraries;Bioinformatics;Cells;Color;Colorado;Confocal Microscopy;cost;Custom;Cytometry;Data;Data Analyses;Data Collection;data handling;Data Storage and Retrieval;Dedications;Device or Instrument Development;Diabetes Mellitus;Educational workshop;Equipment;Event;Experimental Designs;Faculty;Flow Cytometry Shared Resource;Fluorescence Microscopy;Goals;Grant;Human;human imaging;Image;Image Analysis;imaging platform;Immunology;innovation;instrumentation;intravital imaging;Investments;Journals;light microscopy;Lipids;Maintenance;Medical;member;Metabolism;Microscope;microscopic imaging;Microscopy;Mission;Multiplexed Ion Beam Imaging;Nanoscopy;Preparation;Productivity;Reagent;Research;Research Personnel;Resolution;Resource Sharing;Resources;Running;Sampling;Series;Signal Transduction;Sorting;Specialist;Speed;System;Teacher Professional Development;Technology;Tissues;tool;Training;two photon microscopy;two-photon;ultra high resolution;Universities;Validation

PROJECT_TITLE: Cell and Tissue Analysis Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Diabetes;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

PI_NAMEs: RUSS, HOLGER A. (contact)

PROJECT_TERMS: Adult;adult stem cell;assay development;Beta Cell;biobank;Biological Assay;Biological Models;Cell Differentiation process;Cell Line;Cell model;cell repository;cell type;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;cost;cost effective;CRISPR/Cas technology;data sharing;design;Diabetes Mellitus;directed differentiation;Disease;disease model;Ensure;Enzyme-Linked Immunosorbent Assay;Fingerprint;functional genomics;gene correction;gene editing technology;Gene Expression;Generations;Genes;Genetic Models;genome editing;Genome engineering;Goals;Human;human adult stem cell;Human Cell Line;human disease;human embryonic stem cell;human model;human stem cell-derived;human stem cells;human tissue;humanized mouse;Immunotherapy;In Vitro;in vitro Model;in vivo;Individual;induced pluripotent stem cell;Infrastructure;innovation;Institution;Karyotype determination procedure;Laboratories;Libraries;Liver;Luciferases;Medical;member;Microsatellite Repeats;Minisatellite Repeats;Mission;Modeling;Molecular;mouse model;Mycoplasma;novel;Organoids;overexpression;Pancreas;Pancreatic duct;Patients;Peripheral Blood Mononuclear Cell;pluripotency;Pluripotent Stem Cells;Point Mutation;pre-clinical;Procedures;programs;Protocols documentation;Quality Control;Quantitative Reverse Transcriptase PCR;Reagent;Reporter;Reporter Genes;Reproducibility;Research;Research Personnel;Resources;Sampling;Scientist;searchable database;Secure;Services;small hairpin RNA;Standardization;stem cell model;stem cell technology;stem cells;System;Technology;Testing;Time;Tissue Model;Tissue Procurements;Tissues;Training;translational potential;translational scientist;Transplantation;type I and type II diabetes;United States National Institutes of Health;Validation

PROJECT_TITLE: Disease Modeling Core


PI_NAMEs: REUSCH, JANE E (contact)

PROJECT_TERMS: Award;career;Clinical Sciences;Collaborations;Colorado;Communities;Consultations;Data;Diabetes Mellitus;diabetes risk;Discipline;Evaluation;Fostering;Funding;Goals;Grant;high risk;Home;immunoregulation;improved;Individual;innovation;Institution;Investigation;Knowledge;Leadership;Medical;member;Mentorship;Modeling;novel;Organoids;Physiological;Process;programs;Publications;Qualifying;recruit;Research;Research Personnel;Research Project Grants;sex as a biological variable;Talents;tool;Training;Translational Research;United States National Institutes of Health;Universities;Vocational Guidance

PROJECT_TITLE: P and F Program


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Lung;Lung Cancer;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative. Cigarette smoking is now the leading killer of people with HIV (PWH) in the US, and most cessation strategies tried to date have failed to increase long-term quit rates. An “all or none” approach to smoking cessation in PWH offers little benefit to the large majority of PWH who are unable or unwilling to quit. In this proposal we argue that a harm reduction approach (i.e. cut down, get screened for lung cancer, control your blood pressure and cholesterol) has the potential to yield significant benefits in terms of the private and public health of PWH in the US.

PI_NAMEs: SHUTER, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: CICCOLO, JOSEPH THOMAS

PROJECT_TERMS: Abstinence;Acquired Immunodeficiency Syndrome;Age;Alcoholic beverage heavy drinker;American;American Heart Association;Antismoking;Appointment;Appointments and Schedules;arm;Atherosclerosis;atherosclerosis risk;Behavior;Behavioral;Biochemical;blood lipid;Blood Pressure;cancer risk;Cardiology;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;Caring;cerebrovascular;Cholesterol;Cigarette;cigarette smoke;Cigarette Smoker;cigarette smoking;Clinic;Clinical;clinical care;clinical practice;cohort;Collaborations;college;Communities;cost effective;cost effectiveness;Cost Effectiveness Analysis;Counseling;Country;Data;Data Set;design;economic cost;economic outcome;Epidemic;Equation;Evaluation;evidence base;experience;Funding;Future;General Hospitals;Goals;Grant;Guidelines;Harm Reduction;Health;Health behavior;Helping to End Addiction Long-term;HIV;Hybrids;improved;Individual;Internet;Intervention;intervention effect;Life;low dose computed tomography;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Massachusetts;Measurement;Medical;Medical center;Medicine;Methodology;Methods;Modeling;models and simulation;Morbidity - disease rate;mortality;mortality risk;Movement;online community;Online Systems;Outcome;Participant;patient navigator;Persons;pharmacologic;Pharmacotherapy;Population;Pregnant Women;Prevalence;prevent;primary outcome;Privatization;Process;programs;Provider;Public Domains;Public Health;Published Comment;Publishing;Qualifying;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Resources;Risk;risk mitigation;Role;simulation;Smoke;Smoker;Smoking;smoking cessation;Smoking History;sobriety;Social Justice;Subgroup;Textiles;Therapeutic;Time;tobacco control;Tobacco use;tobacco user;Translating;Transportation;treatment arm;treatment as usual;United States National Institutes of Health;varenicline;web site;Work;World Health

PROJECT_TITLE: Trial of a harm reduction strategy for people with HIV who smoke cigarettes

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Women's Health Research

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative Employing a range of methods with extant quantitative data and newly collected qualitative data to study the link between having young adult children with serious conditions and mothers’ health in late-midlife, this project situates the health risks and benefits of aging mothers, the strains and rewards of parenting, and the needs of young adults within the overall life course, the parenting career, and ecological context while elucidating thorny social psychological processes that explain why some mothers suffer in late-midlife while others are resilient. This approach can better serve this increasing number of American women by identifying when and where to intervene and facilitating better understanding of what they need. In these ways, this theoretically grounded and policy-focused project on vulnerability and resilience in a growing population of older American women captures the spirit of Healthy People 2030 and advances many general goals of NIH.

PI_NAMEs: CROSNOE, ROBERT LYLE (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Address;Adult;Adult Children;Age;Aging;aging population;aging process;American;Area;Attention;autistic children;Benefits and Risks;Birth;Blindness;Buffers;cardiovascular health;care giving burden;career;caregiving;Caring;Child;Child Care;Child Rearing;Chronic;Communities;Community Health;Complex;Data;Data Collection;design;developmental disease;disability;Down's Syndrome;early onset;Ecology;Equilibrium;Evolution;experience;Face;Family;Family Study;family support;Fathers;Foundations;Funding;Future;Gender Role;Generations;Goals;Health;health disparity;health of the mother;Healthcare;Human;human old age (65+);Impaired cognition;Individual;innovation;insight;Institution;intergenerational;Intervention;Journals;Knowledge;late life;Life;Life Cycle Stages;Link;Literature;Lived experience;Marriage;Maternal Health;maternal outcome;Measures;Medical;Mental disorders;Mental Health;Methods;middle age;Modeling;Modernization;mortality;Mothers;National Longitudinal Survey of Youth;Nature;Older Population;Parents;Pathway interactions;Pattern;Personal Satisfaction;Persons;physical conditioning;Policies;Population;Population Database;population health;Population Study;Positioning Attribute;Process;programs;promote resilience;Psyche structure;psychologic;Public Health;public health research;Publishing;Research;Research Methodology;resilience;Resources;Rewards;Risk;Services;Shapes;Slice;social;Source;Statistical Data Interpretation;Stress;Techniques;theories;Therapeutic;Time;transition to adulthood;Treatment Efficacy;United States National Academy of Sciences;United States National Institutes of Health;Woman;Work;young adult

PROJECT_TITLE: The Health of Aging Parents of Adult Children with Serious Conditions

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Congenital Structural Anomalies;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE We seek to understand the mechanisms underlying human thalamocortical pathway development and to study how genetic mutations found in patients with neurodevelopmental psychiatric disorders may disrupt the thalamocortical pathway formation. In order study these processes in human cell-based models, we will take advantage of human pluripotent stem cell technology which enables scalable in vitro differentiation into tissue models of the cerebral cortex and the thalamus. Moreover, using cutting-edge single cell sequencing technologies, we will identify the molecular pathways that may be involved in regulating thalamocortical pathway development in humans.

PI_NAMEs: NOWAKOWSKI, TOMASZ  (contact);RUBENSTEIN, JOHN L. R.;SOHAL, VIKAAS SINGH

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: 22q11;22q11.2;Attention deficit hyperactivity disorder;autism spectrum disorder;Axon;Benchmarking;Biological Assay;Brain;Calcium;cell fate specification;Cell Line;Cell Nucleus;cell type;Cells;Cerebral cortex;Clustered Regularly Interspaced Short Palindromic Repeats;cognitive task;Complex;Data;Data Set;Defect;Dejerine Roussy Syndrome;Development;Developmental Delay Disorders;differentiation in vitro;differentiation protocol;DiGeorge Syndrome;Disease;DNA Sequence Alteration;epigenomics;Epilepsy;exome sequencing;Fiber;FOXP2 gene;Functional disorder;Gene Expression;Genes;Genetic study;genetic variant;genomic data;Glutamates;Goals;Growth;Heterozygote;Human;Human Development;human model;human pluripotent stem cell;human tissue;Image;in vivo;Individual;induced pluripotent stem cell;innovation;Instruction;Investigation;knock-down;Mediating;Mental disorders;microdeletion;Modeling;Molecular;Motor;mouse development;mouse model;Movement Disorders;Mus;Mutation;neural;neural circuit;neural patterning;Neurodevelopmental Disorder;Neuroglia;neuroimaging;Neuronal Differentiation;Neurons;neuropsychiatric symptom;Organoids;overexpression;Pathway interactions;Patients;Phenotype;Pluripotent Stem Cells;preference;Process;Protocols documentation;Radial;Role;Schizophrenia;Sensory;Series;single cell genomics;single cell sequencing;single-cell RNA sequencing;Specific qualifier value;Specificity;stem;stem cell model;stem cell technology;Study models;Syndrome;Technology;Testing;Thalamic structure;thalamocortical tract;Tissue Model;Tissues;tool;transcription factor;transcriptomics;Work

PROJECT_TITLE: Neurodevelopmental defects of the thalamocortical pathway as a convergent feature of psychiatric disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MDCN-P(57)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Lyme Disease;Neurosciences;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: GRAND FORKS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

ORG_STATE: ND

PHR: The proposed project will contribute to our knowledge of how infection by B. burgdorferi, the causative agent of Lyme disease, establishes disease of the central nervous system. We will elucidate how bacterial factors and host immune responses to B. burgdorferi contribute to neuroinflammation and pathology.

PI_NAMEs: BRISSETTE, CATHERINE AYN (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Acute;Address;Affect;Animal Model;Anti-Inflammatory Agents;Antibiotic Therapy;Arthritis;Asia;Bacterial Adhesins;Biology;Blood Vessels;Borrelia;Borrelia burgdorferi;Brain;brain parenchyma;Cardiac;CD8-Positive T-Lymphocytes;Cells;Central Nervous System;Central Nervous System Diseases;Cephalic;Clinical;Clinical Research;cytokine;debilitating symptom;density;diagnostic criteria;Disease;Dura Mater;Encephalitis;Europe;experience;Functional disorder;Genes;Genetic;Genotype;Headache;Heart;Hippocampus;Immune;Immune response;Immune signaling;Infection;Inflammation;Inflammatory;innovation;insight;Integration Host Factors;Interferon Type II;Interferons;Intervention;Joints;Laboratories;Leucocytic infiltrate;Lyme Arthritis;Lyme Disease;Lyme Neuroborreliosis;lyme pathogenesis;lymphatic drainage;Lymphocyte;Macaca;Meningeal;Meningeal Layer of the Dura Mater;Meninges;Meningitis;Modeling;Mus;Needles;Nervous System;Neuritis;neuroinflammation;Neurologic;Neurologic Effect;nonhuman primate;Order Spirochaetales;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Pathology;Pathway interactions;Patients;Rattus;Reporting;Research;Research Support;response;Risk Factors;Role;Severities;Short-Term Memory;Signal Transduction;Sterility;Strategic Planning;Study models;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic Intervention;tick transmission;Tick-Borne Diseases;tick-borne pathogen;Time;Tissues;United States;United States National Institutes of Health;Vasculitis;Vector-transmitted infectious disease;verbal;Virulence Factors;Work;working group

PROJECT_TITLE: Bacterial and host factors in the pathogenesis of Lyme neuroborreliosis

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: PROJECT NARRATIVE How multiple transcription factors interact at cis-regulatory elements to regulate transcription remains a fundamental question in biology. In this proposal, we will exploit the regulation of rhythmic transcription by the mammalian circadian clock to uncover fundamental mechanisms by which transcription factors cooperate and compete with histones to control transcription. Our findings are expected to provide important insights into the mechanisms that enable the circadian clock to coordinate the temporal organization of biological processes across the 24-hour day, and more generally into how transcription factor cooperativity regulate transcription.

PI_NAMEs: MENET, JEROME  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;Affect;Animals;ARNTL gene;Binding;Binding Sites;Biological;Biological Process;Biology;Cell Nucleus;Chromatin;chromatin immunoprecipitation;circadian;circadian pacemaker;circadian regulation;Coupled;Data;Data Set;DNA;DNA Binding;Enhancers;Environment;Etiology;Event;Excision;experimental study;Exposure to;feeding;Frequencies;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;genome-wide;Goals;High Fat Diet;Histones;Hour;in vivo;Inflammatory Response;insight;Knowledge;Label;Literature;Liver;Location;Mammals;Mediating;Methods;Methyltransferase;Modality;Modeling;Mus;NF-kappa B;novel;Nucleosomes;Organ;Pathologic;Pathway interactions;Periodicity;permissiveness;Physiological;Positioning Attribute;Post-Translational Protein Processing;Process;programs;recruit;Regulation;Regulator Genes;Regulatory Element;Reporting;Research;Role;single molecule;Techniques;Testing;Tissues;transcription factor;Transcriptional Activation;Transcriptional Regulation;transcriptome;Variant

PROJECT_TITLE: Cooperation between transcription factors and its role in the regulation of rhythmic enhancer activity by the circadian clock

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Dystonia;Genetics;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHICAGO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The overall goal of this project is to determine the cellular mechanisms responsible for neurodevelopmental disorders associated with mutations in the gene, ATP1A3. This gene encodes a protein involved with maintaining ion gradients in neurons, which are required for normal neuron function. ATP1A3 mutations cause severe childhood-onset neurological diseases with inadequate treatment options, and our work will help inform new therapeutic strategies.

PI_NAMEs: GEORGE, ALFRED L. (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Action Potentials;Acute;alternating hemiplegia;ATP1A3 gene;Cell model;Cell Survival;cerebral atrophy;Childhood;Chronic;Compensation;cytotoxicity;Developmental Delay Disorders;Disease;Dominant-Negative Mutation;driving force;Dystonia;effective therapy;Epilepsy;Equilibrium;excitatory neuron;Exhibits;experimental study;extracellular;Functional disorder;gamma-Aminobutyric Acid;gene therapy;Genes;Genetic;Goals;Hemiplegia;Heterozygote;Homeostasis;Human;human induced pluripotent stem cells;Impairment;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Ions;knock-down;Knock-out;Learning;loss of function;loss of function mutation;Loss of Heterozygosity;Measurement;Mediating;Membrane;Membrane Potentials;Migraine;Modeling;Molecular;Monitor;mutant;Mutation;mutation correction;Nervous System Disorder;neurodevelopment;Neurodevelopmental Disorder;Neurologic Dysfunctions;Neurologic Symptoms;neuron loss;Neuronal Differentiation;Neuronal Dysfunction;neuronal excitability;Neurons;neurotoxicity;neurotransmission;novel therapeutic intervention;optogenetics;Outcome;Pathogenesis;Patients;pharmacologic;Physiological;Predisposition;prevent;Proteins;Pump;Recovery;Resources;Rest;Secondary to;Splice-Site Mutation;symporter;Symptoms;Syndrome;Testing;Time;Transgenes;Viral;voltage;Work

PROJECT_TITLE: Cellular Pathophysiology of Neuronal Na/K-ATPase Dysfunction

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAINT LOUIS

ORG_DEPT: GENETICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  The WashU-VAI Somatic Mosaicism across Human Tissues (SMaHT) Program Genome Characterization Center (SMaHT-GCC) will identify and characterize multiple types of human somatic variation (SNVs, structural variants, and mobile DNA elements) from multiple tissues from multiple donors using high-throughput genomic sequencing including long-read sequencing and single cell sequencing, provide these data to the SMaHT Data Analysis Center, and ultimately contribute to the construction of the SMaHT Variant Catalog.

PI_NAMEs: FULTON, ROBERT SCOTT;SHEN, HUI ;WANG, TING  (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: Affect;Autopsy;Bioinformatics;bioinformatics tool;Biological;Biological Assay;Biological Process;Biology;Cataloging;Catalogs;Collaborations;Collection;community engagement;computerized data processing;Data;Data Analyses;data infrastructure;data integration;data management;data quality;data visualization;design;Disease;DNA sequencing;DNA Transposable Elements;Elements;epigenomics;experience;flexibility;Genetic Transcription;Genome;Genome Data Analysis Network;genome resource;genomic data;Genomic DNA;genomic variation;Genomics;Goals;Health;Human;human pangenome;human tissue;improved;Information Systems;life span;Mediating;member;Modernization;Mosaicism;Nucleosomes;Phenotype;Production;programs;quality assurance;Recommendation;Research;response;Sampling;scientific computing;single cell sequencing;Somatic Mutation;System;Technology;The Cancer Genome Atlas;Time;Tissue Procurements;Tissues;tool development;Toxicant exposure;transcriptome sequencing;transposon/insertion element;Variant;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-K(70)R]


ADMINISTERING_IC: OD

ED_INST_TYPE: PRIMATE CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: SEATTLE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Washington National Primate Research Center: Narrative  Overall Component The Washington National Primate Center’s Mission is inherently linked to the mission of the National Institutes of Health as one of its primary resources for scientists requiring the nonhuman primate model in research for the improvement of human and animal health within the United States, and world-wide.

PI_NAMEs: OSTENDORF, MARI  (contact)

PROGRAM_OFFICER_NAME: BUHRING, BETTINA D

PROJECT_TERMS: 2019-nCoV;Achievement;Administrative Personnel;animal care;animal colony;Animal Experimentation;Animal Husbandry;Animal Model;animal resource;Animal Welfare;Animals;Applications Grants;Arizona;Basic Science;Behavior;Biology;Biomedical Research;Breeding;Budgets;Caring;clinical care;Clinical Sciences;Collaborations;Communicable Diseases;Communication;Communities;Development;Diagnostic;Discipline;Disease;Documentation;Educational Status;Elements;Ensure;Environment;Ethics;Faculty;field study;Funding;Future;gene therapy;Genes;Genomics;Goals;Guidelines;Health;Human;Immunology;improved;Infrastructure;innovation;Institution;International;Knowledge;Leadership;Letters;Link;Location;Macaca;Macaca nemestrina;medical specialties;Methods;Mission;Modeling;neural prosthesis;Neurosciences;next generation;nonhuman primate;novel strategies;operation;Organizational Change;Outcome;outreach;Pathology;Performance;Personal Satisfaction;Postdoctoral Fellow;Primates;programs;Recommendation;recruit;Regenerative Medicine;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Resources;Science;Scientific Advances and Accomplishments;Scientist;Services;Site;Societies;Specialist;stem cells;Strategic Planning;Structure;student training;Study models;Training;training opportunity;translational medicine;Transplantation;United States;United States National Institutes of Health;Universities;virology;Washington;Well in self;Work


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eye Disease and Disorders of Vision;Neurosciences

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative Our ability to recognize the category, or behavioral significance, of visual stimuli is essential for planning and carrying out successful behaviors in response to our surroundings. The goal of this research project is to provide a detailed and mechanistic understanding about how the brain learns and recognizes visual categories. A detailed understanding of these brain mechanisms is critical for understanding and ultimately addressing the profound deficits of learning, memory and visual recognition that frequently accompany brain diseases and conditions such as stroke, schizophrenia and Alzheimer’s disease.

PI_NAMEs: FREEDMAN, DAVID J (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Affect;Aging;Alzheimer's Disease;Animals;Area;area MT;Attention;Attention Deficit Disorder;Behavior;Behavioral;Brain;brain based;Brain Diseases;Categories;Child;Cognition;Cognitive;cognitive process;Color;Communication;covert attention;Data;Decision Making;Development;directed attention;Disease;Dyslexia;Environment;Event;experience;extrastriate visual cortex;Eye Movements;Foundations;frontal eye fields;Functional disorder;Funding;Geometry;Goals;Human;Impairment;Individual;Injury;insight;Knowledge;Laboratories;lateral intraparietal area;Learning;Learning Disabilities;Libraries;Location;Manuals;Mediating;Memory;Monitor;Monkeys;Motion;neural;neural correlate;Neurons;next generation;novel;oculomotor;Parietal Lobe;Patients;Pattern;Perception;pharmacologic;Play;Population;Prefrontal Cortex;Primates;Publishing;Reporting;Research;Research Project Grants;response;Role;Saccades;Sampling;Schizophrenia;School-Age Population;Sensory;sensory stimulus;Space Perception;Stimulus;Stroke;superior colliculus Corpora quadrigemina;Task Performances;Techniques;Testing;Textbooks;Time;Touch sensation;Training;Visual;visual learning;Visual Motion;visual performance;visual processing;visual stimulus;Work;young adult

PROJECT_TITLE: Cortical Mechanisms of Visual Category Recognition and Learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-U(02)M]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Relevance Disruptions of mitochondrial structure have been found in many neurodegenerative and mitochondrial diseases which afflict millions of people worldwide with tremendous global economic and societal burdens. An effective treatment is desperately needed but the underlying molecular and cellular mechanisms of their destructive path remain poorly understood. This proposal aims to elucidate the mechanisms underlying mitochondrial strucutral maintenance and provide novel therapeutic strategies to alleviate oxidative damage, is therefore relevant to public health and the mission of the NIH.

PI_NAMEs: WANG, XINNAN  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Address;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;ATP Synthesis Pathway;Axon;Behavior;Biochemical;Cells;Charcot-Marie-Tooth Disease;Complex;Crista ampullaris;crista membrane;Disease;Drosophila genus;Economics;effective therapy;experimental study;fly;Health;Homeostasis;human disease;Huntington Disease;Impairment;improved;in vivo;Inner mitochondrial membrane;Knowledge;Length;Macromolecular Complexes;Maintenance;Membrane;Metabolic Diseases;Mission;Mitochondria;Mitochondrial Crista;Mitochondrial Diseases;Modification;Molecular;Nerve Degeneration;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;novel therapeutic intervention;novel therapeutics;Organism;Outcome;oxidation;oxidative damage;Oxidative Phosphorylation;Oxidative Stress;Parkinson Disease;Pathogenicity;Pathologic;Persons;Phenotype;Phosphorylation;Physiological;polarized cell;Post-Translational Protein Processing;Proliferating;Public Health;Reaction;Regulation;response;Role;Series;Signal Transduction;Site;stressor;Structure;synaptic function;System;Testing;United States National Institutes of Health

PROJECT_TITLE: Molecular Regulations of Mitochondrial Structure in Neuronal Homeostasis and Survival

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Bioengineering;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW YORK

ORG_DEPT: CHEMISTRY

ORG_NAME: HERBERT H. LEHMAN COLLEGE

PHR: Project Narrative Most medications are molecules that work by binding tightly to a specific pocket in the surface of a protein involved in a disease process, and thus blocking the protein’s disease-related function. This project aims to develop advanced computational methods and software that will speed the discovery of new medications by helping scientists identify druggable pockets on protein surfaces then design or discover molecules that will bind tightly to a targeted protein.

PI_NAMEs: KURTZMAN, THOMAS PHILIP (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: 2019-nCoV;Binding;Binding Proteins;Computer software;computerized tools;Computing Methodologies;Databases;design;Disease;Docking;drug candidate;Drug Design;drug discovery;Drug Targeting;Hydration status;improved;Lead;lead optimization;Maps;Membrane Proteins;Methods;Modification;Molecular;mu opioid receptors;Pattern;Peptide Hydrolases;Pharmaceutical Preparations;pharmacophore;Physics;Process;Proteins;Scientist;Shapes;Speed;Structure;Surface;Thermodynamics;tool;virtual;virtual screening;Water;Work

PROJECT_TITLE: Solvation directed drug design: from molecular physics to lead optimization

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project narrative. Diabetic retinopathy is a vascular complication of long-term diabetes, and the vascular complications of diabetes are associated with increased levels of extracellular vesicles in plasma, but from where those extracellular vesicles originated from has not been defined. Evidence that neural retina contributes to the etiopathogenesis of diabetic retinopathy is accumulating, and the research proposed in this application will unravel the role of retina- derived extracellular vesicles in the disease. I propose a multipronged approach to understand the influence of retina-derived extracellular vesicles in the development of diabetic retinopathy, the role of the visual cycle in their cargo sorting, and potential therapies to inhibit the interaction of retina-derived extracellular vesicles and the recipient cells, including retinal endothelial cells and leukocytes.

PI_NAMEs: LESSIEUR, EMMA M (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adherence;Adhesions;Affect;Age;Anatomy;Animals;antagonist;Area;Binding;Blindness;Blood capillaries;Blood Vessels;Cell Adhesion;Cell Adhesion Molecules;Cell Communication;Cell Line;Cell Surface Receptors;Cells;Characteristics;Chronic;Clinical;Complication;Complications of Diabetes Mellitus;cytotoxicity;Data;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Retinopathy;Disease;Disease Progression;Endothelial Cells;Etiology;Eukaryotic Cell;experimental study;Exposure to;extracellular vesicles;Eyedrops;Foundations;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;Injections;insight;Integral Membrane Protein;Intercellular adhesion molecule 1;intravitreal injection;Investigation;Learning;leukocyte activation;Leukocytes;Light;Mediating;Methodology;Methods;Modeling;Molecular;monolayer;mouse model;multiple omics;Mus;mutant mouse model;nanoscale;Neural Retina;non-diabetic;novel;novel therapeutic intervention;Parents;Pathogenesis;Pathologic;Pathology;Permeability;pharmacologic;Phenotype;Photoreceptors;Physiological;Plasma;Population;post-doctoral training;Preparation;Process;Proteins;Protocols documentation;Publishing;receptor;Receptor Cell;Reporter;Reporting;Research;Retina;Retinal Diseases;Rhodopsin;Rod;Role;Route;Secondary to;Sorting;Strategic Planning;Structure;Surface;Systemic Therapy;Tail;targeted treatment;Testing;Tissues;TLR4 gene;Transgenic Mice;Transgenic Organisms;Up-Regulation;Vascular Diseases;Vascular Endothelium;Veins;vesicular release;virtual;visual cycle;Visual impairment;Work

PROJECT_TITLE: Retina-derived extracellular vesicles in diabetic retinopathy: their potential role in pathogenesis and therapy


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Alzheimer's disease (AD) is a significant health problem in the United States that poses great medical and socioeconomical burdens to this country, the solving of which demands new molecular insights into its mechanisms of development. Here we employ human brain samples, advanced cell models and epigenomic techniques to explore a new area of enhancer-derived RNAs in human brain gene deregulation and AD pathology. This study will lead to molecular characterization of unexplored ncRNA players in AD that can provide novel targets and pathways for AD diagnosis and therapeutic intervention.

PI_NAMEs: LI, WENBO  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: 3-Dimensional;Aberrant DNA Methylation;Address;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's Disease Pathway;Alzheimer's disease risk;apolipoprotein E-4;Architecture;Area;Binding;Biological;Biology;Brain;brain cell;Cause of Death;Cell model;Cell Nucleus;cell type;Cells;Chemicals;ChIP-seq;Chromatin;Chromatin Conformation Capture and Sequencing;chromatin modification;chromosome conformation capture;Coenzyme A;Cognitive;Complex;Country;Dementia;Deterioration;Development;Disease;DNA;DNA Binding;Economic Burden;Elderly;Enhancers;Epigenetic Process;epigenomics;Fishes;Fluorescent in Situ Hybridization;Gene Expression;Gene Expression Regulation;Gene Mutation;Genes;Genetic;Genetic Risk;Genetic Transcription;genetic variant;Genome;genome wide association study;Health;Hi-C;Histone Acetylation;Human;improved;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;insight;Interferons;Intervention;Knowledge;Lead;Mediating;Medical Economics;Methods;Methylation;methylome;Microglia;Modeling;Modification;Molecular;Neurons;new therapeutic target;novel;Nuclear;Nuclear RNA;Oncogene Deregulation;Organoids;Pathogenesis;Pathologic;Patients;Play;Population;prevent;programs;Proteins;Reader;reduce symptoms;Regulation;Research Personnel;response;Ribonucleoproteins;Risk;risk variant;RNA;RNA-Binding Proteins;Role;Sampling;Signal Induction;Signal Transduction;socioeconomics;Symptoms;tau mutation;tau Proteins;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;therapy development;transcription factor;transcriptome;United States;Untranslated RNA;Variant;Work

PROJECT_TITLE: Enhancer RNAs in brain gene regulation and Alzheimer's disease


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Hematology;Immunotherapy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: PROJECT NARRATIVE The Center for International Blood and Marrow Transplant Research (CIBMTR) plays a unique and important role in facilitating clinical research in hematopoietic stem cell transplantation (HCT) and adoptive cellular therapy (ACT). It is committed to developing its research database, in volume and scope; its statistical expertise; and data sharing capabilities, to meet the needs of investigators in a rapidly evolving field. This award will allow CIBMTR to build on the infrastructure made possible by support from U24-CA076518 to better serve the research and healthcare community and to address issues important to patients.

PI_NAMEs: PASQUINI, MARCELO C.;SHAW, BRONWEN  (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Address;Adoptive Cell Transfers;Aftercare;American;Award;Biological Specimen Banks;Blood;blood resource;Bone Marrow Transplantation;CAR T cell therapy;Caring;Cell Therapy;Cells;Cellular immunotherapy;Clinical;clinical care;Clinical Data;clinical practice;Clinical Research;Clinical Trials Network;Collaborations;Communities;Correlative Study;Data;Data Collection;data resource;data sharing;Databases;Dedications;Disease;Electronics;Ensure;Equity;Event;Evidence based practice;experience;follow-up;Funding;gene therapy;genetically modified cells;Goals;Health;health assessment;health care service utilization;healthcare community;Hematologic Neoplasms;Hematological Disease;Hematology;Hematopoietic Stem Cell Transplantation;Human;Impairment;Improve Access;improved outcome;Individual;Industry;Infection;Infrastructure;Infusion procedures;innovation;International;international center;Knowledge;Late Effects;Life Cycle Stages;Link;Long Term Survivorship;Longterm Follow-up;Malignant - descriptor;Malignant Neoplasms;Mission;Multiple Partners;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;Neoplasms;Non-Malignant;novel;novel strategies;Observational Study;Organ;Outcome;Outcome Assessment;Patient Outcomes Assessments;Patients;Play;Policies;programs;prospective;Publications;Quality of Care;Quality of life;Registries;Request for Applications;Research;Research Personnel;Research Support;Resource Development;Resources;Risk;Risk Factors;Role;Services;Societies;Solid Neoplasm;Source;Speed;support tools;synergism;System;Technology;Therapeutic Studies;tool;Toxic effect;Transplant Recipients;transplantation therapy;treatment center;trend;United States;United States Food and Drug Administration;United States National Institutes of Health;usability

PROJECT_TITLE: A Data Resource for Blood and Marrow Transplants and Adoptive Cellular Therapy Research


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_DEPT: SURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Human patients suffering from sweat gland deficiencies are unable to properly maintain body temperature, which can lead to hyperthermia, heat stroke, brain damage, and potentially death. We will investigate the molecular mechanisms underlying sweat gland development at different stages and how the progenitor cells respond to environmental cues which shape the morphogenesis. Upon completion our work will significantly advance our knowledge in sweat gland biology, as well as facilitate development of novel strategies to regenerate sweat glands for the patients who loss sweating ability to regain thermoregulation.

PI_NAMEs: LU, CATHERINE PEI-JU (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Affect;ATAC-seq;Biology;Biomedical Engineering;Body Temperature;Brain Injuries;Burn injury;Cell Culture System;cell fate specification;Cell Separation;Cells;Cessation of life;Collagen;conditional knockout;Cues;Data;Dermal;Dermis;design;Development;Developmental Biology;Developmental Process;Duct (organ) structure;Eccrine Glands;Engineering;Environment;epidermal stem cell;Equilibrium;Event;experimental study;Fibroblasts;Future;Gland;gland development;Glandular Cell;Goals;Heat Stroke;Human;Hyperthermia;innovation;insight;keratinocyte;Knock-out;Knockout Mice;Knowledge;Lead;Length;Ligands;Light;mechanical force;Mechanics;Methods;microfluidic technology;microscopic imaging;Molecular;Morphogenesis;mouse genetics;mouse model;Multipotent Stem Cells;Mus;Natural regeneration;notch protein;novel;novel strategies;Organ failure;overexpression;Patients;Pattern;Physiologic Thermoregulation;Piezo 1 ion channel;progenitor;Regulation;Research;Research Proposals;response;Role;severe burns;Shapes;Signal Pathway;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Skin;skin regeneration;spatiotemporal;Specific qualifier value;stem cell biology;stem cell therapy;stem cells;Sweat Glands;Sweating;Technology;Testing;Tissue Engineering;Tissues;Water;WNT Signaling Pathway;Work

PROJECT_TITLE: Molecular Mechanisms in Sweat Gland Development

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Infectious Diseases;Prevention;Rare Diseases;Stomach Cancer

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Project Narrative These studies will define mechanisms and identify people who are at greatest risk for H. pylori- induced stomach cancer, which will greatly improve the diagnosis and therapy of this disease.

PI_NAMEs: PEEK, RICHARD M. (contact)

PROGRAM_OFFICER_NAME: GEORGE, CHRISTINA DAWN

PROJECT_TERMS: adaptive immune response;Address;Affect;antimicrobial;Attenuated;Biological Models;Cancer Etiology;cancer risk;carcinogenesis;carcinogenicity;Cell Survival;Cells;Cessation of life;Chronic;Clinical;Coculture Techniques;cohort;Colombia;Complex;cytokine;Data;Detection;Development;Diagnosis;Digestive System Disorders;Disease;Disease Progression;disorder risk;DNA;Epithelial Cells;Epithelium;Feedback;follow-up;Freezing;Funding;Gastric Adenocarcinoma;gastric carcinogenesis;gastric organoids;Gastric Tissue;Genetic;genetic manipulation;Helicobacter Infections;Helicobacter pylori;Helicobacter pylori induced carcinogenesis;Helicobacter pylori induced gastric cancer;Histologic;Human;Immune;Immune response;Immune system;improved;Inflammation;Inflammatory;Inflammatory Response;innovation;interleukin 9 receptor;Interleukin-9;Laboratories;Lesion;Link;lonely individuals;Macrophage;Malignant Neoplasms;malignant stomach neoplasm;Microbe;microbial;Modeling;Molecular;Mucous Membrane;NF-kappa B;novel;Oncogenic;pathogen;Pathogenicity;Pathway interactions;Pattern recognition receptor;Peptidoglycan;Persons;Positioning Attribute;premalignant;Production;prospective;Proteins;receptor;Regulation;Risk;Risk Factors;Rodent Model;Sampling;Signal Pathway;Signal Transduction;Stomach;System;T-Lymphocyte;Testing;Time;Tissues;tumorigenesis;Type IV Secretion System Pathway;Validation

PROJECT_TITLE: H. Pylori Relationship to Digestive Diseases and Cancer