NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetic Testing;Genetics;Human Genome;Infertility;Prevention

ORG_CITY: Salt Lake City

ORG_NAME: INHERENT BIOSCIENCES, INC.

PHR: NIH SBIR Fast-Track Application: Inherent Biosciences NARRATIVE NOA is the most severe form of male factor infertility where no sperm are present in the ejaculate, affecting 1% of men worldwide. Currently, men with NOA have low chances of conceiving a child of their own and commonly have genetic disorders that are associated with poor long term health outcomes. Despite all the innovations in reproductive medicine, men with NOA are left with essentially one invasive and expensive procedure, microdissection testicular sperm extraction or mTESE, to isolate sperm, which has a >50% failure rate. Inherent Biosciences proposes the development of a single diagnostic test to be used on all men presenting with NOA (39.7 million men worldwide) that leverages new discoveries of cell-free DNA analysis in the semen to accurately predict the likelihood of retrieving sperm in an mTESE procedure and assess the genetic causes of NOA.

PI_NAMEs: BROGAARD, KRISTIN R (contact)

PROJECT_TERMS: Affect;American;Area;Biological Assay;Biological Sciences;Biopsy;bisulfite sequencing;Cardiovascular Diseases;cell free DNA;Child;Chronic;clinically actionable;Collaborations;commercialization;Conceptions;cost;Couples;Data;Development;Diagnosis;Diagnostic tests;DNA;DNA analysis;Ejaculation;Epigenetic Process;Failure;Fertilization in Vitro;Funding;Genetic;Genetic Counseling;genetic counselor;Genetic Diseases;Genetic Screening;genetic testing;Grant;Health;health management;high risk;improved;Infertility;infertility treatment;innovation;insight;Klinefelter's Syndrome;Laboratories;Left;life span;Link;male;male health;Male Infertility;Malignant Neoplasms;Marketing;men;Metabolic Diseases;Methods;microdeletion;Microdissection;Modeling;Molecular Abnormality;neuropsychiatry;new technology;novel;Outcome;Patients;Physicians;poor health outcome;Population;Procedures;Production;prognostic indicator;Protocols documentation;Reproductive Health;Reproductive Medicine;Research;Retrieval;Sampling;Seminal;Seminal fluid;Seminal Plasma;Seminiferous tubule structure;Severities;Small Business Innovation Research Grant;Societies;Solid;sperm cell;subfertility;success;Testing;Testis;Uninsured Medical Expense;United States National Institutes of Health;Universities;Unnecessary Procedures;Y chromosome microdeletions;zygote

PROJECT_TITLE: Novel Epigenetic Test for the Treatment and Improvement of Longitudinal Health-Outcomes for Men with Severe Infertility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-K(10)B]


ADMINISTERING_IC: PS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STD AND TB PREVENTION

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The objective of the proposed implementation science research project is to develop and pilot IntégraTE, an implementation strategy to increase HIV Pre-Exposure Prophylaxis (PrEP) accessibility and quality of care for Latino men who have sex with men (LMSM) in three Federally Qualified Health Centers (FQHCs) in the Atlanta Metropolitan Area. In alignment with the Minority HIV/AIDS Research Initiative (MARI) and the End the HIV Epidemic (EHE) Prevent pillar, this study aims to increase technical capability of local community clinics to provide cultural-concordant PrEP care to a group with high HIV vulnerability and to increase scientific knowledge to the portfolio of promising evidence-based interventions specifically designed for LMSM by addressing LMSM-specific social and structural barriers to PrEP uptake. From a clinical practice and public health perspective, we anticipate that improving PrEP accessibility for LMSM would lead to an increase in PrEP linkage and prescription among LMSM at the partner FQHCs, effectively leading to a decrease HIV transmission in these communities.

PI_NAMEs: CANTOS, VALERIA D. (contact)

PROJECT_TITLE: PS24-063, MARI:  Integration of Latino MSM-tailored Oral and Long-Acting Injectable PrEP Services in Federally Qualified Health Centers in the Atlanta area (IntegraTE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZPS1 SPE (60)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF TORONTO

ORG_STATE: ON

ORG_ZIPCODE: M5S 1S8

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health since elucidation of how ferrochelatase modulates angiogenesis and development of ferrochelatase-targeting therapies will lead towards new treatments for common neovascular eye diseases such as age-related macular degeneration, proliferative diabetic retinopathy, and retinopathy of prematurity. The proposed research is thus also directly relevant to the National Eye Institute’s mission of supporting research with respect to blinding eye diseases.

PI_NAMEs: CORSON, TIMOTHY W (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Address;Age related macular degeneration;angiogenesis;Angiogenesis Inhibitors;Biology;Blindness;burden of illness;Carbon;Cell Physiology;cell type;Cellular biology;Cementation;Characteristics;Chemicals;Choroidal Neovascularization;cofactor;common treatment;complex IV;cytochrome c oxidase;Data;Development;Disease;Down-Regulation;Drug Kinetics;Dysmorphology;efficacy testing;Endothelial Cells;Enzyme Inhibition;enzyme pathway;Enzymes;Exudative age-related macular degeneration;Eye;Eye diseases;ferrochelatase;Genetic Transcription;Genus Hippocampus;Glucose;Glycolysis;Goals;Grant;Heme;heme biosynthesis;Hemeproteins;high throughput screening;Human;Impairment;In Vitro;in vivo;in vivo Model;inhibitor;innovation;Ions;knock-down;Knowledge;Lasers;Lead;life span;Link;Mediating;Mediator;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mission;Mitochondria;mitochondrial dysfunction;Modeling;mouse model;mRNA Expression;Mus;Mutation;National Eye Institute;Natural Products;neovascular;neovascularization;novel;nucleotide metabolism;Nucleotides;ocular angiogenesis;ocular neovascularization;Oral;Oxidative Phosphorylation;Oxygen;Pathologic Neovascularization;Pathway interactions;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;prevent;Process;Production;Proliferating;proliferative diabetic retinopathy;Proteins;Proteome;protoporphyrin IX;Public Health;Publishing;Reactive Oxygen Species;Regulation;Research;Research Support;Retina;Retinal Diseases;Retinal Neovascularization;Retinopathy of Prematurity;Role;small molecule;Specificity;stable isotope;success;synergism;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;therapeutic target;tool;Toxic effect;Transcriptional Regulation;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Ferrochelatase as a mediator of ocular angiogenesis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Infant Mortality;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: RENO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: PROJECT NARRATIVE  The proposed project is relevant to public health because complications associated with preterm birth are the leading cause of infant mortality in the United States. This project is relevant to the NICHD mission because it will provide the foundation to determine if MMP2/9 substrates can serve as druggable targets to promote uterine quiescence and reduce the number preterm births.

PI_NAMEs: BURKIN, HEATHER R (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Automobile Driving;Birth;Data;druggable target;experimental study;Foundations;Future;Gelatinase A;Genes;Human;Infant Mortality;Link;Matrix Metalloproteinases;Metalloproteases;Mission;MMP9 gene;Molecular;mouse model;National Institute of Child Health and Human Development;parent project;Parents;Patients;Play;Premature Birth;Proteins;Public Health;Regulation;response;Role;Tissues;United States;Uterine Contraction;Uterus

PROJECT_TITLE: MMP9 Modulation of Uterine Contraction and Birth Timing


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative The proposal aims to study two areas in the brain that are affected early in Alzheimer’s disease. We will use advanced gene expression techniques to understand how changes in these areas lead to memory loss and sleep problems. This will be combined with existing data on electrophysiology, behavior and sleep data.

PI_NAMEs: HUSSAINI, S. ABID  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Affect;Alzheimer's Disease;Amyloid beta-Protein;Area;Arousal;Behavior;Brain;Brain region;Core Facility;Data;Dimensions;Early identification;Electrophysiology (science);entorhinal cortex;Evaluation;Functional disorder;Gene Expression;Gene Modified;Generations;Genes;Goals;Grant;Human;Immunologic Monitoring;Impaired cognition;Injections;Knock-in;Knock-in Mouse;large datasets;Lead;locus ceruleus structure;Medial;Memory impairment;Memory Loss;memory process;Mus;Neuronal Dysfunction;Neurons;parent grant;Parents;Pathology;Property;Research Personnel;response;Sleep;Sleep Disorders;Sleep disturbances;spatial memory;tau aggregation;tau Proteins;Tauopathies;Techniques;Technology;Time;Tissues;tool;transcriptomic profiling;transcriptomics;Visualization;Visualization software

PROJECT_TITLE: Electrophysiological Evaluation of Brain Regions Vulnerable to Alzheimer's Disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE In 2021, a Centers for Disease Control and Prevention HIV surveillance report indicated that Latinx communities accounted for 29% of new HIV diagnoses but comprised only 19% of the US population. In that same year, male-to-male sexual contact accounted for 67% of all new HIV diagnoses. In response to these HIV disparities, this project will adapt an existing evidence-based, community-level HIV prevention intervention to focus on Latinx sexual and gender minority (LSGM) individuals and will seek to dismantle medical mistrust and misinformation as social determinants of health. The long-term goal of this research is to prevent new HIV transmissions among LSGM by improving engagement in HIV prevention services, including PrEP. This research is in alignment with the US Ending the HIV Epidemic (EHE) initiative, and research activities will be conducted in Chicago and Cook County, IL - one of the 50 EHE jurisdictions.

PI_NAMEs: GREENE, GEORGE JESUS (contact)

PROJECT_TITLE: PS24-063, MARI:  Understanding Medical Mistrust to Inform Adaptation of an HIV Prevention Intervention for Latinx Sexual and Gender Minorities


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PHR: NARRATIVE The proposed project is to develop an educational program to train nurse scientists and scientists in aligned disciplines to conduct research focused on Social Determinants of Health. This program is alignment with NINR’s strategic plan to increase the numbers of investigators that are trained to be ethically and critically engaged in SDOH research and to ultimately decrease the health inequities experienced among underrepresented groups.

PI_NAMEs: HAMILTON, JILL B (contact);STERK, CLAIRE E;WALDROP, DRENNA

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: Address;Aging;Applications Grants;behavioral health;Behavioral Research;Biomedical Research;Cardiovascular Diseases;climate change;Clinical Research;Cognition;Collaborations;Communities;Competence;Data Science;Development;Dimensions;Discipline;Discipline of Nursing;Disease Outcome;disorder risk;Doctor of Philosophy;doctoral student;early-career faculty;Education;education research;Educational Curriculum;Ensure;Ethics;experience;Exposure to;Faculty;Family;Fostering;Funding;Goals;hands on research;Health;health application;health disparity;health inequalities;health knowledge;Individual;Infrastructure;innovation;interdisciplinary approach;interest;investigator training;Knowledge;knowledge integration;Licensure;Maintenance;Malignant Neoplasms;meetings;Mentors;Mentorship;Methodology;mid-career faculty;Mission;Modeling;next generation;Nurses;Nursing Research;Office Nursing;Outcome;Policies;posters;Prevention strategy;programs;Public Health;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;School Nursing;Science;Scientist;skills;social health determinants;social influence;Societies;Strategic Planning;Students;Training;training opportunity;Underrepresented Populations;United States National Institutes of Health;Universities

PROJECT_TITLE: Advanced Research Training in SDOH (ART)

STUDY_SECTION_NAME: Special Emphasis Panel[ZNR1 REV-N (06)]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: JACKSONVILLE

ORG_NAME: ENVIRONMENTAL MUTAGENESIS/GENOMICS SOC

ORG_STATE: FL

PHR: Members of the Environmental Mutagenesis and Genomics Society (EMGS) have expertise in multiple disciplines covering all aspects of basic and applied research on mechanisms and consequences of responses to genotoxic agents. Integration of these disciplines remains the central focus of the Society, and the annual meetings are key to the dissemination of information and fostering of interactions between researchers and individuals who must make informed regulatory decisions with respect to environmental health hazards. The meetings provide a forum in which students, postdoctoral fellows, and early stage investigators can develop and enhance their careers by sharing information with established scientists through formal scientific sessions and informal interactions.

PI_NAMEs: BEMIS, JEFFREY C (contact)

PROGRAM_OFFICER_NAME: OVERTON, KYLE

PROJECT_TITLE: Environmental Mutagenesis and Genomics Society (EMGS) Annual Meeting 2024-2028

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 NCTR-T (01)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative To tackle the increasing health-related challenges associated with SDOH, health The ideal way to prepare nursing and other professional health researchers with SDOH-related skills to generate critical change is to offer continuous training opportunities by way of short courses that include CBPR and intersectoral considerations.

PI_NAMEs: WALLINGTON, SHERRIE LEE (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Acceleration;Address;Advocacy;Affect;American;American College of Physicians;base;Biological;Care given by nurses;Caring;Categories;clinical practice;Codes of Ethics;cohort;Collaborations;college;Communication;Communities;community based participatory research;community collaboration;community engagement;Community Health;Competence;continuing nursing education;Credentialing;Data;design;Development;disability;Discipline;Discipline of Nursing;Disparity;Diverse Workforce;Education;Educational Curriculum;Educational process of instructing;Enrollment;Evaluation;Faculty;Feedback;Future;Gender;Goals;Health;Health education;health equity;health inequalities;health knowledge;Health Professional;Health Promotion;Healthcare;Human Rights;improved;Individual;Inequity;interest;intersectionality;Intervention;Journals;Knowledge;Lead;Learning;lens;Life Cycle Stages;Measures;Methods;Modeling;Nurses;Occupations;Outcome;Pathway interactions;Patient Care;Peer Review;Play;Policies;Politics;Population;population health;Population Heterogeneity;practical application;Prevention;Professional Organizations;programs;Race;recruit;Reduce health disparities;Research;Research Personnel;research study;Role;satisfaction;School Nursing;Scientific Advances and Accomplishments;Scientist;Self Efficacy;sex;Sex Orientation;skills;social;social factors;social health determinants;Social Justice;socioeconomic disadvantage;Standardization;symposium;System;Thinness;tool;Training;training opportunity;Translational Research;Translations;Underserved Population;Universities;Update;Vulnerable Populations;Washington

PROJECT_TITLE: Advancing Social Determinants of Health Research through A CBPR Lens:  A Short Course


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: NARRATIVE Low level chronic inflammation is a hallmark of Type 2 diabetes mellitus. How inflammatory cytokines affect the function of pancreatic beta cells is insufficiently understood. The present project examines the negative impact of the inflammatory cytokine tumor necrosis alpha (TNFα) on the response of pancreatic beta cells to incretin hormones. Incretin hormone action is defective in diabetes and which are critical for normal glycemic control. We will also examine how targeting anti-inflammatory nicotinic acetylcholine receptors can restore the defective incretin action in beta cells and ameliorate diabetes mellitus.

PI_NAMEs: HUSSAIN, MEHBOOB A (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Ablation;Acetylcholine;ADRBK1 gene;Affect;Alpha Cell;alpha-bungarotoxin receptor;Anti-Inflammatory Agents;Beta Cell;Binding;Biochemical;Cell Physiology;Cells;Chemosensitization;cholinergic;Chronic;Circulation;Coupled;Cyclic AMP;cytokine;Diabetes Mellitus;diet-induced obesity;Electrophysiology (science);Endocrine;Event;Exocytosis;Functional disorder;G-Protein-Coupled Receptors;Gastric Inhibitory Polypeptide;Gene Expression;Gene Expression Profile;Genetic Transcription;GLP-I receptor;glucagon-like peptide 1;Glucose;glucose receptor;glycemic control;Glycerol;GTP-Binding Protein alpha Subunits, Gs;GTP-Binding Proteins;Hormones;Human;improved;In Vitro;in vivo;incretin hormone;Inflammation;Inflammatory;Ingestion;Inositol;insight;Insulin;insulin secretion;Interleukins;Intestines;islet;Islet Cell;Islets of Langerhans;L Cells;Ligands;Link;Macrophage;Mediating;Metabolism;Molecular;mouse model;Mus;Necrosis;Neurotransmitters;Nicotinic Receptors;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Obesity;Outcome;Pathway interactions;Patients;Peptide Receptor;Peripheral;pharmacologic;Phosphorylation;Phosphotransferases;Physiological;Proinsulin;Property;receptor;Receptor Signaling;recruit;Regulation;Resistance;response;Role;Serine;Signal Pathway;signal recognition particle receptor;Signal Transduction;Source;Stimulus;Structure of beta Cell of islet;System;Tissues;TNF gene;TNFRSF1A gene;translational impact;tripolyphosphate;tumor

PROJECT_TITLE: Mechanism of Defective Incretin Action in Beta Cells during Type 2 Diabetes Mellitus

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The aim of the proposed research is to test the impact of a primary care-based intervention to prevent obesity in low-income Latino infants and toddlers. Latino children are at high risk of obesity and other diseases linked to obesity including type 2 diabetes. The goal of this study is to learn how to best promote health behaviors in early life that will result in lower risk of obesity in childhood and across the lifespan.

PI_NAMEs: BECK, AMY LAURA (contact)

PROGRAM_OFFICER_NAME: WALKER, JENELLE ROSE

PROJECT_TERMS: acceptability and feasibility;Acculturation;Address;Age;attentional control;Behavior;behavior change;Behavioral;Beverages;Birth;Body mass index;Breast Feeding;California;Caregivers;Child;Child Health;Childhood;Clinical;Consumption;dietary;Dietary Practices;Disease;Disparity;early childhood;experience;Family;Family Caregiver;Family Characteristics;Family member;family structure;fatty liver disease;feeding;Feeding behaviors;Food;Food Selections;Fruit;fruits and vegetables;Future;Goals;Guidelines;Health;Health behavior;Health education;Health Educators;Health Personnel;Health Promotion;Healthcare;high risk;Home;Hypertension;Immigrant;improved;infancy;Infant;Infant Care;Intake;Intervention;intervention cost;intervention effect;intervention participants;Interview;Juice;Language Development;Latino;Learning;Life;life span;lifetime risk;Link;Low income;Low Income Population;Mediating;Mediation;Mediator;Metabolic;Modality;Modeling;modifiable risk;Modification;Motivation;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Nurses;Nutritionist;Obesity;obesity in children;obesity prevention;obesity risk;obesogenic;Outcome;Parents;Pattern;Persons;Physicians;pilot test;pilot trial;Population;Poverty;pregnancy health;Primary Care;primary care clinic;primary care setting;primary care visit;primary outcome;Provider;Public Health;Qualitative Methods;Randomized;Recommendation;recruit;reinforced behavior;Research;Resources;response;Risk;Risk Factors;Role;Safety;secondary outcome;sedentary lifestyle;Site;skills;Sleep;sleep behavior;Source;Structure;Study models;sugar;sweetened beverage;Techniques;Technology;Testing;Text Messaging;text messaging intervention;Toddler;trend;tv watching;United States;Visit;Weight;Well Child Visits

PROJECT_TITLE: Sources of on information on pregnancy health and infant care among Latino immigrant parents

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The goal of this application is to develop innovative technologies that improve the in vivo quantification of hyperphosphorylated tau using PET imaging and enhance its utility in both research and eventual clinical settings. Once validated, we anticipate that our methodology could be readily adapted for application to other existing or newly reported tau imaging agents.

PI_NAMEs: EL FAKHRI, GEORGES  (contact);NORMANDIN, MARC DAVID

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Address;Affinity;Age;aging related disease;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyloid deposition;Behavior;Binding;Blood flow;Blood specimen;Brain;Cerebrum;Clinic;Clinical;Complement;Complex;Data;Data Analyses;Data Collection;Data Set;deep learning;deep learning model;deep neural network;Deposition;Differential Diagnosis;Diffusion;Disease;Evolution;Excision;Exhibits;Factor Analysis;follow-up;Future;Generations;Goals;healthy aging;high resolution imaging;human subject;hyperphosphorylated tau;Image;Image Analysis;image reconstruction;imaging agent;Imaging technology;improved;in vivo;indexing;Individual;innovative technologies;insight;kernel methods;kinetic model;Kinetics;locus ceruleus structure;Logistics;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methodology;Methods;Modeling;molecular imaging;Motion;Nature;Nervous System Disorder;neuroimaging;novel;Pathology;Patients;Pattern;Perfusion;Phase;Physiological;Positron-Emission Tomography;predictive modeling;preservation;Property;Protocols documentation;quantitative imaging;radiotracer;reconstruction;Reporting;Research;research study;Resolution;response;Scanning;Signal Transduction;simulation;spatiotemporal;Structure;tau Proteins;Techniques;Testing;Time;Tracer;Training;uptake;Water

PROJECT_TITLE: Methods for Quantitative Neuroimaging of Tau Burden in Pre-symptomatic AD

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Depression;Mental Health;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Pregnancy;Social Determinants of Health;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: TUCSON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Intimate partner violence (IPV) includes assault to the head, neck, and face, with approximately 90% of survivors reporting symptoms concordant with persistent post-concussion symptoms, wherein pregnancy is associated with increased intensity and frequency of physical assault. Like stress, drugs, and inflammation, traumatic brain injury (TBI) during pregnancy, from IPV, falls, motor vehicle accidents, can increase the environmental risk for neurodevelopmental disorders in the children. The proposal extends strong proof-of-principle results to explore the outcomes of gravida TBI – TBI during pregnancy – in mice on the neurobehavioral, neurocircuitry, and molecular phenotypes of offspring to better inform science, education, and policy making.

PI_NAMEs: LIFSHITZ, JONATHAN  (contact);QIU, SHENFENG

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Adult Children;Anxiety;anxiety reduction;assault;automobile accident;Behavior;behavioral phenotyping;Birth;Brain;cell cortex;cell type;Cells;Child;Cognition;Data;Databases;depressive symptoms;Development;developmental disease;Diffuse;Education;Electrophysiology (science);Environmental Risk Factor;Face;falls;Female;fetal;Frequencies;Gene Expression;Goals;Head;Hippocampus;immune activation;Immune response;Inflammation;intimate partner violence;Investigation;Laboratory Study;Lasers;Life;Live Birth;male;men;Mental Depression;Molecular;molecular phenotype;Morphology;Mus;Neck;neural circuit;neurobehavioral;neurodevelopment;Neurodevelopmental Disorder;Neurons;neuropsychiatry;offspring;Outcome;Performance;Persons;Pharmaceutical Preparations;Phenotype;physical assault;Physiology;Policy Making;Post-Concussion Syndrome;postnatal;Pregnancy;pregnant;protein expression;Proteins;Race;Reporting;Research;Risk;Scanning;Science;Social Behavior;socioeconomics;Standard Model;Stress;Survivors;Symptoms;Synapses;Testing;transcriptomics;Traumatic Brain Injury;vehicular accident;Weaning;Weight;Western Blotting;Woman;young adult

PROJECT_TITLE: Gravida traumatic brain injury (TBI) impacts neurodevelopment of the offspring

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Project Narrative The present project has the goal of testing the idea that the accelerated aging (senescence) that accompanies the genetic changes in Downs syndrome can spread between brain cells (support cells, neurons) and synapses by exosomes, which are nanoscale small vesicles related to cell communication will be simultaneously isolated from the same human tissue samples. This proposal will directly address the contribution of the major brain cell types to senescence mechanisms and progression of pathology in human samples, critical for advancing senolytic therapies and biomarkers of Alzheimer’s disease.

PI_NAMEs: BILOUSOVA, TINA ;GYLYS, KAREN H (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Acetaminophen;Address;Adult;Age;age acceleration;aged;Aging;aging related disease;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid beta-Protein;Appearance;Astrocytes;Autoimmunity;Autopsy;Basic Science;Beginning of Life;beta-Galactosidase;Biological Markers;Brain;brain cell;Cd68;Cell Aging;Cell Communication;Cell Line;Cell Physiology;Cell secretion;Cell Separation;cell type;Cells;Chromosome 21;Coculture Techniques;cognitive testing;Congenital chromosomal disease;Cryopreservation;Curiosities;cytokine;Data;Dermatologic;Development;Diagnosis;Disease;Disease Progression;Dissociation;Distal;Distant;DNA Damage;DNA Repair;Down's Syndrome;Endocrine system;exosome;experimental study;extracellular vesicles;Flow Cytometry;Foundations;glial activation;glioma cell line;Goals;Heart Diseases;Homeostasis;Human;human disease;human model;human tissue;Hypertension;IL6 gene;Immune;improved;In Vitro;Individual;Induced Neurons;Infection;Inflammaging;Inflammatory;Interferons;Laboratories;Late Onset Alzheimer Disease;Link;Malignant Neoplasms;Mediating;Mediator;Methods;Microglia;MicroRNAs;Mitochondria;Modeling;mouse model;Musculoskeletal System;Mutation;nanoscale;Neprilysin;Nerve;Neuroblastoma;Neuroglia;neuroinflammation;Neurons;novel;Oxidative Stress Induction;p38 Mitogen Activated Protein Kinase;Pathologic;Pathology;Pathway interactions;Peptide Hydrolases;Performance;Phenotype;Population;postmitotic;Predisposition;Premature aging syndrome;Presynaptic Terminals;Proteins;Publications;response;Risk;Sampling;seal;senescence;senescence associated secretory phenotype;senescent cell;senolytics;sensory system;Signal Transduction;single nucleus RNA-sequencing;Solid Neoplasm;stem cell exosomes;Supporting Cell;Synapses;Synaptosomes;tau Proteins;Testing;Therapeutic;Therapeutic Effect;therapeutic enzyme;therapeutic target;Time;Tissue Model;Tissue Sample;Tissues;Toxin;transcriptomics;translational impact;Ubiquitin;Vaccination;Vesicle;Vulnerable Populations;Work

PROJECT_TITLE: TS21 Effects on Senescence/SASP in neurons, glia and cell-specific exosomes, and spread of phenotype in vitro

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Q(55)R]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: SALT LAKE CITY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: No change from original application.

PI_NAMEs: LENZI, TOMMASO  (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TITLE: Lightweight Powered Prosthesis for Above-knee Amputees

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Aging;Dietary Supplements;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative Growth stunting and poor nutrition are global health problems, especially for mothers and infants. Improving maternal nutritional status prior to pregnancy may provide health benefits for both mother and child. This proposal will test if growth stunting and maternal nutritional status impact the epigenome of infants at birth and 3 months. We will also assess if the epigenome influences infant growth in the first 2 years of life.

PI_NAMEs: BORENGASSER, SARAH JEAN (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: 5 year old;accelerated epigenetic aging;Address;Adult;Age;age acceleration;Anthropometry;arm;Binding;Birth;Birth length;Body mass index;Cardiovascular Diseases;Cells;Child;Child Health;Chronic Disease;Chronology;Conceptions;Consumption;Cytosine;Data;Democratic Republic of the Congo;Dietary Intervention;Dinucleoside Phosphates;Disease;DNA Methylation;early-life nutrition;Educational Status;Epigenetic age;epigenetic clock;epigenetic marker;Epigenetic Process;epigenome;Ethnic Origin;Female;fetal;Genetic Transcription;Genomic Segment;Gestational Age;global health;Goals;Growth;Growth and Development function;Guanidines;Guatemala;Health;Health Benefit;healthspan;Human;human capital;improved;India;Individual;Infant;Life;Link;Lipids;low and middle-income countries;low income country;male;Malignant Neoplasms;Malnutrition;methyl group;Methylation;methylation biomarker;Micronutrients;Molecular;Morbidity - disease rate;mortality;mother nutrition;Mothers;Neonatal;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;nutrition;Nutritional status;Obesity;offspring;Pakistan;Phenotype;Placenta;postnatal;Pregnancy;prepregnancy;Randomized, Controlled Trials;Reporting;Resource-limited setting;response;Risk;rural area;sex;Testing;three-arm study;treatment arm;Vulnerable Populations;Woman

PROJECT_TITLE: Preconception Maternal Nutrition, Offspring DNA Methylation, and InfantGrowth in Low Resource Settings

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative The proposed research is relevant to public health because social disconnection is a major risk factor for poor physical and mental health and it rises steeply during adolescence. The project is relevant to NICHD’s priorities because it seeks to understand social isolation across development, reveal family-level risk and protective factors for social disconnection, and identify targets for behavioral and biological intervention.

PI_NAMEs: HOSTINAR CAUDILL, CAMELIA E (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Acute;Adolescence;Adolescent;Adult;Affect;affiliative behavior;Age;Behavior;Behavioral;biobehavior;Biologic Characteristic;Biological;biological adaptation to stress;Biological Assay;Biology;California;Characteristics;Conflict (Psychology);COVID-19 pandemic;Data;Data Collection;Development;emerging adulthood;Emotional;Evaluation;Exhibits;experience;Family;fighting;Fostering;Freezing;Future;Health Benefit;high school;Inflammatory;Intervention;Introversion;Laboratories;Loneliness;longitudinal dataset;Longitudinal Studies;Low income;Mental Health;Mexican;Modeling;National Institute of Child Health and Human Development;Neurotic Disorders;Oxytocin;parent project;Parents;Participant;Pattern;peer;Personality;Personality Character;physical conditioning;Physiological;Population;Prevalence;Process;prospective;protective factors;Protocols documentation;Public Health;Reaction;recruit;Reporting;Research;response;Risk Factors;Role;Sampling;Schools;secondary analysis;Shyness;social;Social Behavior;Social Development;Social Distance;social exclusion;social factors;Social isolation;social relationships;social stressor;Social support;Stress;stress reactivity;stressor;Testing;theories;Time;twelfth grade;Withdrawal;Youth

PROJECT_TITLE: Understanding the Development of Social Disconnection in Youth


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Diabetes;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PORTLAND

ORG_NAME: IFOCUS IMAGING LLC

ORG_STATE: OR

PHR: Project Narrative Vision loss due to diabetic retinopathy (DR) must be confronted with new tools. In this application, IFOCUS IMAGING LLC will combine two of the most important recent innovations in ophthalmology- artificial intelligence and optical coherence tomography angiography imaging- to meet this challenge. The goal of this work is to develop a reliable, user-friendly, and commercially available platform that will fit seamlessly into the clinic and reading centers and provide both with the necessary means to combat blindness from DR.

PI_NAMEs: HORMEL, TRISTAN  (contact);JIA, YALI

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: accurate diagnosis;Adoption;Adult;Affect;Age;aging population;Algorithms;Ally;Angiography;Area;Artificial Intelligence;Basic Science;Blindness;Blood capillaries;Blood Vessels;Classification;Clinic;Clinical;clinical decision-making;clinical imaging;Clinical Management;clinical practice;Clinical Research;combat;Communities;Computer software;Consumption;cost effective;Data;Decision Making;design;Detection;Development;Devices;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Diagnosis;Diagnostic;diagnostic platform;Diagnostic Specificity;Disease;Disease Management;Dyes;Edema;effective therapy;Ensure;Environment;explainable artificial intelligence;Eye;Eye diseases;Funding;Fundus photography;Goals;Health;Human;Image;Image Analysis;image processing;imaging modality;improved;improved outcome;innovation;Intervention;Liquid substance;Longevity;macula;macular edema;Medical Imaging;network architecture;novel;Ophthalmology;Optical Coherence Tomography;Oregon;Output;Pathologic;Pathology;Patient-Focused Outcomes;Patients;Performance;Persons;Phase;pressure;Prevalence;prevent;Prevention;Procedures;Process;Reading;Research;Research Personnel;Resolution;Retina;Retinal Neovascularization;Scanning;Science;screening;self-attention;Severities;Specialist;Specificity;Staging;standard of care;Technology;technology development;Therapeutic Research;Time;Tissue imaging;tool;Training;Universities;user-friendly;Vision;Work

PROJECT_TITLE: A diagnostic platform for diabetic retinopathy based on OCT angiography and artificial intelligence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-M (12)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NORTH CHARLESTON

ORG_NAME: EXPANSE BIO LLC

ORG_STATE: SC

PHR: NARRATIVE Every year, thousands of potentially transplantable kidneys are not used and for every 5 waitlist patients who die, or become too sick for transplantation, 3 kidneys are discarded. Organ preservation would address organ shortage by (a) enabling clinical immune tolerance induction, (b) greatly expanding options for donor-recipient matching and equitable allocation, (c) enhancing screening for transmissible diseases and malignancies, (d) decreasing costs and enabling flexible scheduling of surgeries, and (e) allowing for organ quality assessment and reconditioning. Infants and small children in need of a transplant have an especially hard time finding a suitable donor nearby and during the specific time period, resulting in a higher organ discard rate than adults. Serendipitously, the physics of heat transfer make it exponentially easier to cryopreserve smaller pediatric vs. larger adult organs. Our team have recently demonstrated the world’s first and only, successful, repeat transplants after ice-free cryogenic preservation of mammalian kidneys using the nanowarming technology. Building on the project’s Phase I feasibility success, in this Phase II project, we will apply our combined expertise in nanowarming, organ machine perfusion and organ transplant to young pediatric size kidneys in a juvenile pig model and human pediatric kidneys.

PI_NAMEs: BISCHOF, JOHN C;FINGER, ERIK BRIAN;TING, ALISON Y;WEEGMAN, BRADLEY P (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: 3-Dimensional;Acceleration;Achievement;Address;Adolescent;Adult;authority;Autologous Transplantation;Award;biomaterial compatibility;Biomedical Research;Brain Death;Child;Childhood;Clinical;Clinical assessments;clinical practice;clinical translation;combinatorial;Complex;conditioning;Congresses;Convection;cost;cryogenics;Cryopreservation;Cryopreserved Tissue;Cryoprotective Agents;Data;Disease;End stage renal failure;Equity;European;experience;Family suidae;fertility preservation;Fingers;flexibility;Fracture;Glass;Goals;Graft Rejection;Graft Survival;Growth;Heating;high throughput screening;Human;Ice;Immune Tolerance;Immunosuppression;improved;Incidence;Inequity;Infant;Inferior;Injury;innovation;iron oxide nanoparticle;Kidney;kidney preservation;Kidney Transplantation;Lead;Letters;life span;Link;Living Donors;Logistics;Malignant Neoplasms;Marketing;Modeling;Modification;nanoparticle;nanowarming;natural hypothermia;Nature;Neonatal;neonate;new technology;novel strategies;older patient;Operative Surgical Procedures;Organ;organ allocation;Organ Donor;Organ Preservation;Organ Transplantation;Organ Viability;Oryctolagus cuniculus;Outcome;Patients;Performance;Perfusion;PF4 Gene;Phase;phase 1 study;Physics;Play;porcine model;preconditioning;preservation;prevent;prospective;Protocols documentation;Publishing;Quality-Adjusted Life Years;radio frequency;Randomized;Rattus;Recovery;Reperfusion Therapy;Rewarming;Role;scale up;Schedule;screening;Slice;success;Surgeon;Techniques;Technology;Time;Tissue Engineering;Tissues;Toxic effect;Transplantation;Transportation;United Network for Organ Sharing;United States National Institutes of Health;Waiting Lists;Woman

PROJECT_TITLE: Neonatal and Young Pediatric Kidney Preservation through Nanowarming and Vitrification

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-R (11)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: DALLAS

ORG_DEPT: NEUROSURGERY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Narrative Not applicable.

PI_NAMEs: DUNCAN, DOMINIQUE ;POURATIAN, NADER  (contact)

PROGRAM_OFFICER_NAME: JANES, DANIEL ERIC

PROJECT_TERMS: Anatomy;Human Resources;neurophysiology

PROJECT_TITLE: BRAIN Integrated Resource for Human Anatomy and Intracranial Neurophysiology


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Project Narrative This study will examine Cav1.2 L-type Ca2+ channels and its interacting signaling molecules within defined neuronal cell types in extinction of cocaine contextual memories. The findings have the potential to form the basis for developing novel treatment approaches to benefit cocaine dependent individuals.

PI_NAMEs: RAJADHYAKSHA, ANJALI M (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: A kinase anchoring protein;addiction;Affect;AMPA Receptors;Behavior;behavior test;Behavior Therapy;Binding;Biochemical;Brain;Brain region;brain reward regions;C-terminal;Calcineurin;Cell Nucleus;cell type;Cells;Cocaine;Cocaine Dependence;cocaine relapse prevention;cocaine seeking;cocaine use;Cocaine Users;Complex;conditioned place preference;cost;Coupling;Cues;Cyclic AMP-Dependent Protein Kinases;dentate gyrus;Development;Dopamine;Dopamine D1 Receptor;Dorsal;drug of abuse;Electrophysiology (science);Event;experience;Extinction;Fiber;gain of function;Gene Expression;Genetic;Genetic Transcription;granule cell;Heterodimerization;hippocampal subregions;Hippocampus;Human;Image;Imaging Techniques;Impairment;improved;in vivo;in vivo calcium imaging;Individual;knock-down;Knock-out;Knowledge;Laboratories;Learning;learning extinction;Maintenance;Maps;Mediating;Memory;Modification;Molecular;Monitor;Mus;mutant;Mutant Strains Mice;neuromechanism;Neurons;novel;nuclear factors of activated T-cells;Nuclear Translocation;Peptides;Permeability;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Photometry;Pre-Clinical Model;Process;Property;Protein Biosynthesis;Protein Deficiency;protein protein interaction;Proteins;recruit;Regional Anatomy;Regulation;Relapse;relapse prevention;Resistance;Rewards;Rodent;Role;Scaffolding Protein;sensor;Signal Transduction;Signaling Molecule;Site;Slice;small hairpin RNA;Societies;Study models;Surface;Synapses;Synaptic plasticity;Techniques;Testing;Training;transcription factor;transcription factor NF-AT c3;Variant;Viral;Work

PROJECT_TITLE: Investigating the mechanistic contribution of Cav1.2 channels in extinction of cocaine-associated memories

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

PHR: Project Narrative Emerging findings by us and others revealed unexpected non-lethal death functions of caspases. We want to understand how these non-canonical functions along with other proteolytic mechanisms are regulated to account for the developmental stage, tissue type, and environmental status of an organism. The findings from this study will help us to understand mechanisms of caspases in developmental and stress responsive cell state transitions that are important to ensure viability.

PI_NAMEs: WEAVER, BENJAMIN P. (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Animals;Biochemical;biological adaptation to stress;Caspase;Cell Communication;cell motility;Cells;Cessation of life;Complex;Cues;Data;Development;Ensure;Gene Expression;Genetic Screening;Goals;MAP Kinase Gene;Mediating;Metabolic;metabolomics;Neurons;novel;Organism;p38 Mitogen Activated Protein Kinase;Proteins;Proteomics;proteostasis;Publishing;Regulation;response;Role;Signal Transduction;Specificity;Stress;Structure;Time;Tissues;ubiquitin-protein ligase

PROJECT_TITLE: Proteolytic Mechanisms Mediating Cell State Transitions in Development and Stress Responses

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Lung;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: Portland

ORG_NAME: PRAPELA, INC.

ORG_STATE: ME

PHR: Preterm infants often have apnea, which consists of pauses in breathing associated with drops in heart rate and becoming blue or pale. This project will complete the development of and then establish the safety, efficacy, and clinical benefit of a hospital incubator pad with stochastic vibrotactile stimulation. The results of this project will provide for FDA clearance of a complementary, non-pharmacological treatment and the first improvement in the clinical management of newborns with apnea of prematurity in over twenty years.

PI_NAMEs: AMBALAVANAN, NAMASIVAYAM ;KONSIN, JOHN PHILLIP (contact);SINGH, RACHANA

PROGRAM_OFFICER_NAME: KOSTOV, YORDAN VALTCHOV

PROJECT_TERMS: Address;Affect;Age;Apnea;Benefits and Risks;biomaterial compatibility;Breakthrough device;Breathing;Caffeine;Caring;Citrates;Clinical;clinical efficacy;Clinical Management;Clinical Research;clinical risk;clinically relevant;clinically significant;commercialization;Complementary therapies;Consensus;Continuous Positive Airway Pressure;Control Groups;cost effective;Data;design;Development;Devices;Dimensions;Direct Costs;Documentation;Dose;Drops;effective therapy;efficacy evaluation;Electromagnetics;Engineering;Enrollment;Event;experience;Frequencies;Future;Gestational Age;group intervention;healthcare burden;Heart Rate;Hospitals;Human;Hypoxemia;improved;inclusion criteria;Incubators;Infant;Infant Care;Intervention;Licensing;Manuals;manufacturing cost;manufacturing facility;Marketing;Masks;Mattresses;Medical Device;Morbidity - disease rate;Newborn Infant;Nonpharmacologic Therapy;novel;Outcome;Outcome Measure;Patients;Pediatrics;Peer Review;performance tests;Pharmacological Treatment;Phase;Positioning Attribute;Power Sources;Pregnancy;premature;Premature Birth;Premature Infant;preterm newborn;primary outcome;prototype;Publishing;Questionnaires;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Reference Standards;Regulatory Pathway;Reporting;Research;respiratory;Risk;Risk-Benefit Assessment;Safety;safety testing;Small Business Innovation Research Grant;Software Validation;standard of care;supplemental oxygen;System;tactile stimulation;Techniques;Technology;Testing;Theophylline;Time;Treatment Efficacy;United States;United States National Institutes of Health;Validation;ventilation;vibration;vibrotactile stimulation

PROJECT_TITLE: Prapela® SVS incubator pad: A cost-effective stochastic vibrotactile device to improve the clinical course of infants with apnea of prematurity.

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: MADISON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative This supplement supports the training of an outstanding PhD student from an underrepresented background in a well-designed, rigorous, interdisciplinary training program in the population sciences. The Center for Demography and Ecology at the University of Wisconsin-Madison offers outstanding and innovative training in demographic research, focused on the areas of fertility and families, poverty and inequality, health and biodemography, and spatial and environmental demography. Trainees pursue research careers across academic, government, and applied research settings. Trainee research increases our understanding of the behavioral, social, and economic processes that shape the health and wellbeing of the American population.

PI_NAMEs: NOBLES, JENNA E. (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TITLE: Diversity supplement


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Emergency Care;Health Services;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE: The Geriatric Emergency care Applied Research network 2.0 – Advancing Dementia Care brings together leaders who have transformed the emergency care of older adults and partners them with Alzheimer's disease and related dementia (ADRD) experts to optimize care and improve the health of older persons with dementia. It will leverage existing networks and organizations to prioritize research gaps and support pilot grant opportunities for future larger-scale, full proposals.

PI_NAMEs: HWANG, ULA Y (contact);SHAH, MANISH N

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acceleration;Accident and Emergency department;Accreditation;Address;Admission activity;advanced dementia;Advisory Committees;Alzheimer's Disease;Alzheimer's disease related dementia;Applied Research;Award;Caregivers;Caring;Collaborations;Communication;Consensus;Consultations;Data;data warehouse;Decision Making;Delirium;Dementia;dementia care;Detection;Development;Dissemination and Implementation;Education;Elderly;Emergency Care;Emergency Department patient;Emergency department visit;Emergency Medicine;Environment;evidence base;experience;Fostering;Foundations;Funding;Funding Opportunities;Future;Geriatrics;Goals;Grant;Growth;Guidelines;Health;Hospitals;implementation science;improved;Informatics;Infrastructure;innovation;Knowledge;large scale data;Lead;learning network;medical specialties;meetings;Multicenter Studies;Network Infrastructure;older adult;Older Population;operation;Persons;Phase;Pilot Projects;Process;Productivity;programs;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Priority;Research Support;Resources;Risk Factors;Science;skills;Testing;United States National Institutes of Health;Update


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Pediatric;Regenerative Medicine

PHR: Project Narrative This study aims to reveal the physiological triggers of cardiac regenerative potential loss during postnatal growth. This will provide novel insights into organ regeneration, possibly suggesting new targets and strategies to treat heart failure.

PI_NAMEs: HUANG, GUO  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Acute;Adrenergic Receptor;Adult;Animals;Applications Grants;B-Cell Activation;B-Cell Lymphoma 6 Protein;BCL6 gene;Birth;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac repair;Cell Cycle;Cell Cycle Arrest;Cell Cycle Regulation;Chemicals;Clinical Treatment;coronary fibrosis;Data;Development;differential expression;Evolution;experimental study;Genes;Genetic;Genetic Models;Growth;Heart;heart dimension/size;Heart Diseases;Heart failure;heart function;Heterocephalus;hormonal signals;Human;Image;improved;inhibitor;Injury;injury and repair;insight;ischemic injury;Knowledge;Light;Loss of Heterozygosity;Mammals;Methods;Microscopy;Mole Rats;mortality;mouse genetics;Mus;mutant;Mutant Strains Mice;Myocardial Infarction;myocardial injury;Nerve;Newborn Infant;novel;organ regeneration;Pathway interactions;Patients;Phenotype;Phylogeny;Physiological;postnatal;Process;Proliferating;Publishing;Receptor Activation;regeneration potential;Regenerative capacity;regenerative repair;Regulation;repaired;Reporting;Repression;response to injury;Rodent;Role;Science;self-renewal;Signal Transduction;Stains;synergism;Thermogenesis;Thyroid Hormone Receptor;Thyroid Hormones;Tissues;transcription factor;Transcription Repressor;transcriptome sequencing;treatment strategy;United States;Up-Regulation;Viral Vector;Weight;Withdrawal;Work;Zebrafish

PROJECT_TITLE: Genetic circuitry governing heart growth and repair

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE Emerging and re-emerging infectious diseases are occurring with increasing frequency and are a threat to human health in the United States and worldwide. To improve knowledge of these diseases and develop the infrastructure to conduct infectious disease research, National Institute of Allergy and Infectious Diseases (NIAID) has formed the Emerging Infectious Diseases Research Centers Network (EIDRC-Net). RTI International and Duke University propose to jointly establish the EIDRC-Net Coordination Center to provide overall Network coordination and communication and to build a research infrastructure to help NIAID respond rapidly to infectious disease outbreaks when they occur.

PI_NAMEs: MOODY, MICHAEL ANTHONY;SEMPOWSKI, GREGORY D (contact)

PROGRAM_OFFICER_NAME: SMITH, RACHELLE MARIE SIMPSON

PROJECT_TERMS: Address;Affect;Area;Award;Benchmarking;biocontainment facility;Biological Assay;Biology;career;Central Africa;Central America;Childhood;cloud based;Collaborations;Communicable Diseases;Communication;Consensus;Coordination and Collaboration;Country;Data;data acquisition;data quality;Disease;Disease Outbreaks;disease transmission;Doctor of Philosophy;electronic data capture system;Emerging Communicable Diseases;Ensure;Epidemic;Event;experience;flexibility;Frequencies;Funding;Geographic Locations;Goals;Health;high risk;Home;Human;improved;Infectious Diseases Research;Information Management;Infrastructure;International;Joints;Knowledge;Laboratories;Leadership;Location;Medical;Medical Research;Mentors;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;next generation;Performance;Persons;Principal Investigator;Privatization;Procedures;Process;programs;Protocols documentation;quality assurance;Reagent;repository;Research;Research Design;Research Infrastructure;Research Personnel;Resource Sharing;Resources;response;Scientist;Security;Site;social media;Southeastern Asia;Specialist;Specimen;success;System;Testing;Training;United States;United States National Institutes of Health;Universities;usability;Vaccines;web site;ZIKA

PROJECT_TITLE: Emerging Infectious Diseases Research Centers Coordination Center (EIDRC CC)


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Reproductive disorders as well as contraception/family planning have major impacts on the health and well being of individuals and their children worldwide. This training program prepares young scientists to address these important problems at the level of basic and translational research and in research-related careers that require expertise in reproductive biology.

PI_NAMEs: PANGAS, STEPHANIE A. (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Reproductive Sciences

PROJECT_TITLE: Comprehensive Mechanisms in Reproductive Sciences


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE: The prevalence of severe allergic disease is on the rise globally; consequently, systemic allergic reactions are also becoming far more frequent, representing a major public health burden causing morbidity for patients, distress for families, and substantial costs for the healthcare system. The proposed project is relevant to the public health because currently there is neither a strategy to identify individuals at high risk of anaphylaxis, nor treatments to prevent this potentially devastating consequence. Upon conclusion, we will understand how tryptase – a protein that contributes to the symptoms of an allergic reaction – can increase the risk for severe anaphylaxis, and use this knowledge to develop new strategies to prevent potentially fatal allergic reactions in humans.

PI_NAMEs: LYONS, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Affect;Allergic;Allergic Disease;Allergic Reaction;Anaphylaxis;associated symptom;autosome;Biological Markers;Bone Marrow;Caucasians;Cell Communication;Cells;Child;Clinical;Clonal Expansion;Coculture Techniques;Copy Number Polymorphism;Data;Development;Disease;Disparate;Distress;DNA Sequence Alteration;Dysplasia;Engraftment;experience;Family;Gene Expression;Gene Expression Profile;Gene Expression Profiling;General Population;Genetic;genetic risk factor;Genetic Transcription;Genotype;Germ Lines;Goals;Growth and Development function;Health Care Costs;Healthcare Systems;high risk;Human;Hypersensitivity;In Vitro;in vivo;Individual;Inherited;innovation;insight;Investigation;Knowledge;Knowledge acquisition;mast cell;mastocytosis;Mendelian disorder;Modeling;Morbidity - disease rate;mouse model;Mutation;Myelogenous;myeloid cell development;Myeloid Cells;Myeloproliferation;Myeloproliferative disease;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Oncology;overexpression;Pathway interactions;patient population;Patients;Pattern;Phenotype;PIK3CG gene;Play;Prevalence;prevent;Prevention;Probability;programs;Proliferating;Protein Isoforms;Proteins;Public Health;Publishing;Reaction;Regulatory Element;Reporting;Research Personnel;Risk;Risk Factors;Role;screening;Serum;Severities;Severity of illness;Stromal Cells;Symptoms;Syndrome;System;targeted treatment;Testing;Text;Therapeutic Intervention;therapeutic target;therapy development;tool;trait;transcription factor;Tryptase;Validation;Work;Xenograft procedure

PROJECT_TITLE: TPSAB1-derived tryptases promote myeloproliferation and anaphylaxis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: Understanding the rules which guide how neuronal patterns are transformed and utilized by downstream structures to produce behavior is critical for our understanding of how abstract patterns become actions and how such transformations are affected in disease. The present proposal examines how neuronal population patterns in upstream circuits are ‘read out’ by downstream observer circuits/mechanisms in the entorhinal cortex – hippocampus - neocortex loop by combining large-scale electrophysiology, optogenetics and imaging in behaving rodents.

PI_NAMEs: BASU, JAYEETA ;BUZSAKI, GYORGY  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Affect;Alzheimer's Disease;Area;Behavior;Brain;cell assembly;Cells;Communication;Coupling;Cytoplasmic Granules;dentate gyrus;Discrimination;Disease;Electrophysiology (science);entorhinal cortex;Epilepsy;experience;experimental study;Goals;granule cell;Hippocampus;Image;Individual;insight;Interneurons;Lateral;learned behavior;Learning;Link;Maps;Maze Learning;Medial;member;Memory;Neocortex;neocortical;Neurologic;neuronal circuitry;neuronal patterning;Neurons;Neurosciences;optical imaging;optogenetics;Parietal Lobe;Pattern;Physiological;Population;Probability;Psyche structure;Pyramidal Cells;Reader;Research Personnel;Rodent;Route;Signal Transduction;Sleep;Stimulus;Structure;Synapses;Testing;Translating;transmission process;vector

PROJECT_TITLE: Transformation of Neuronal Activity in the Entorhinal-hippocampal-neocortex Path

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE This clinical trial proposal seeks to inform guidelines on the induction and maintenance therapy of HIV- associated talaromycosis and will answer three questions: 1) Is induction therapy using a single 10 mg/kg dose of liposomal amphotericin B is more effective than 14 days of the conventional deoxycholate amphotericin B; 2) Is adding flucytosine to amphotericin B more effective than amphotericin B alone?; and 3) Is HIV viral load guided stopping of itraconazole maintenance therapy as effective as the current CD4 guided strategy in prevention of disease relapse?

PI_NAMEs: LE, THUY  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Amphotericin B;Anemia;anti-fungal agents;Antigens;Biological Availability;Blood;burden of illness;Cause of Death;Cessation of life;Chemoprophylaxis;China;clinical practice;Clinical Trials;Clinical Trials Network;cohort;Combined Modality Therapy;Complication;Consent;Consolidation Therapy;cost;Country;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus;deoxycholate;Diagnosis;Disease;disorder prevention;DNA;Dose;effective therapy;Electrolytes;Enzyme-Linked Immunosorbent Assay;EuroQOL;experience;Flucytosine;Formulation;fungicide;fungus;Goals;Guidelines;Half-Life;hazard;HIV;HIV therapy;HIV-1;improved;In Vitro;in vitro activity;Income;India;Infusion procedures;International;Intervention;Itraconazole;Kidney;Knowledge;Life;Liposomes;Maintenance Therapy;Metabolic Clearance Rate;Microbiology;Modality;mortality;Mycoses;neglect;Neoadjuvant Therapy;novel;Outcome;Participant;Patients;Penetration;Penicillium;Persons;Pharmaceutical Preparations;placebo controlled trial;Placebos;Plasma;Prevention;primary endpoint;primary outcome;programs;Quality of life;Randomized;Recurrent disease;Relapse;Research;Resources;secondary outcome;Secondary to;Southeastern Asia;Talaromyces;Testing;Time;Tissues;Toxic effect;Treatment Efficacy;treatment guidelines;treatment strategy;treatment trial;trial design;Urine;Vietnam;Viral Load result

PROJECT_TITLE: Liposomal Amphotericin B and Flucytosine Antifungal Strategies for Talaromycosis (LAmB-FAST)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 VS-A (M1)]


NIH_SPENDING_CATS: Chronic Pain;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_CITY: STONY BROOK

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Contact PD/PI: TANG, SHAO-JUN NARRATIVE Nucleoside reverse transcriptase inhibitors (NRTIs) are the cornerstone of current regimens of combination antiretroviral therapy commonly used for suppressing HIV replication and transmission. However, they are also implicated in the development of neuropathic pain in HIV/AIDS patients. This project will help us better understand the mechanism by which NRTIs causes pain pathogenesis, especially in the context of opioid use. Project Narrative Page 7

PI_NAMEs: TANG, SHAO-JUN  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Adjuvant Therapy;Anti-Retroviral Agents;antiretroviral therapy;behavior test;Cells;Complication;Data;Development;dorsal horn;Exposure to;glial activation;HIV;HIV Envelope Protein gp120;HIV-1;HIV/AIDS;jun Oncogene;Morphine;Mus;neural circuit;neuroAIDS;Neurologic;Neuropathogenesis;Nucleosides;Opioid;opioid use;Pain;painful neuropathy;Pathogenesis;Pathogenicity;Pathologic;Patients;Persons;Pharmaceutical Preparations;Property;Proteins;Quality of life;Regimen;Research;Reverse Transcriptase Inhibitors;Spinal;Testing;transcriptomics;transmission process;Virus Diseases

PROJECT_TITLE: Cellular and circuitry mechanisms of NRTI-induced pain pathogenesis in the context of opioids and HIV


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Currently there is no effective treatment available for cognitive defects in people with Down syndrome (DS). This project will help understand the role of protein synthesis associated with eEF2K/eEF2 signaling in DS-associated cognitive impairments with aging. This work could inform future identification of novel therapeutic targets for DS and related cognitive syndromes.

PI_NAMEs: MA, TAO  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: age related;Aging;aging related;Alzheimer's Disease;Amino Acids;amyloid pathology;Award;Basic Science;behavior test;beta amyloid pathology;Biological Assay;Brain;Chromosome 21;Cognition Disorders;Cognitive deficits;Data;Dementia;Dendritic Spines;design;Development;Disease;Down's Syndrome;effective therapy;Elderly;Electrophysiology (science);Failure;Functional disorder;Future;genetic approach;Genetic Models;Genetic Suppression;genetic testing;gerotherapeutic;Goals;high reward;high risk;human tissue;Image;Impaired cognition;Impairment;improved;Individual;inhibitor;Intellectual functioning disability;Life Expectancy;Ligation;Link;long term memory;Long-Term Potentiation;Maintenance;Mass Spectrum Analysis;Mediating;Memory;Methods;middle age;Molecular;Morphology;mouse genetics;mouse model;mouse Ts65Dn;mRNA Translation;Mus;Neurodegenerative Disorders;Neurons;neuropathology;Neurosciences;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Patients;Peptide Elongation Factor 2;peptidyl-tRNA;Persons;pharmacologic;Pharmacology;Phase;Phosphorylation;Phosphotransferases;postsynaptic;prevent;Protein Biosynthesis;Proteins;Proteomics;Reporting;Repression;Research;Ribosomes;Role;Signal Transduction;Site;small molecule inhibitor;Synapses;synaptic failure;Synaptic plasticity;Syndrome;Testing;Tissue Model;translation factor;United States National Institutes of Health;Up-Regulation;Vertebral column;Work

PROJECT_TITLE: Targeting protein synthesis dysregulation in Down syndrome-associated cognitive impairment with aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-W(55)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: SYRACUSE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Project Narrative: Project Narrative: The prevalence of vision loss from retinal degeneration numbers in the millions world-wide and is expected to double by the year 2050, and despite the development of several promising approaches to restore vision in the blind, progress in developing these therapies has been hampered by challenges in analysis of these methods in animal models. We describe a novel system that analyzes, by machine learning, retinal ganglion cell output in native, degenerated and therapeutically treated blind retinas which can characterize the visual information content of the ‘reanimated’ blind retina and thereby facilitate the development of these technologies. The system developed through this grant, as well as the career development pursued by the investigator, will be readily applicable to the assessment of potential retinal acuity restoration by current and novel therapeutic approaches.

PI_NAMEs: BABINO, DARWIN  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Acceleration;Aftercare;Amacrine Cells;Animal Model;Animals;animation;Applications Grants;Assessment tool;behavior test;Behavioral Assay;Biological;blind;Blindness;career development;cell type;Cells;Collaborations;Cone;Contrast Sensitivity;cost effective;Data;density;Development;Discipline;Dissection;Doctor of Philosophy;Ectopic Expression;effective intervention;Electrophysiology (science);Electroretinography;Evolution;experimental study;Feedback;Fostering;Ganglia;ganglion cell;Genetic;Goals;Grant;Human;Image;improved;In Vitro;in vivo;Incubated;Individual;induced pluripotent stem cell;inhibitor;interest;Intervention;K-Series Research Career Programs;Knockout Mice;Knowledge;Leadership;Learning;Light;light intensity;Machine Learning;Measurable;Measurement;Measures;Mediating;Mentors;Methods;mimicry;mouse model;Movement;multi-electrode arrays;Mus;mutant;MW opsin;nonhuman primate;novel;novel therapeutic intervention;Opsin;optogenetics;Output;Photoreceptors;Postdoctoral Fellow;pre-doctoral;Prevalence;promoter;Protocols documentation;Psychophysics;rapid eye movement;Research;Research Design;Research Personnel;Resolution;response;restoration;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;Retinal Ganglion Cells;Retinal gene therapy;Rhodopsin;Rod;Rodent;Saccades;Sampling;scale up;Scanning;Science;Scientist;sight restoration;skills;small molecule;Specificity;stem cell replacement;stem cells;Stimulus;Synapsins;System;Techniques;technology development;Testing;Therapeutic;therapy development;tool;Training;Transgenic Organisms;Universities;vector;Viral;Vision;vision science;Visual;Visual Acuity;visual information;Visual System;Voltage-Gated Potassium Channel;Washington;Wild Type Mouse;Work

PROJECT_TITLE: Assessment of murine retinal acuity ex vivo by machine learning of multielectrode array recordings

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PI_NAMEs: HENNIGAR, STEPHEN R. (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TITLE: Mediating effects of hepcidin on iron requirements with undernutrition


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: WASHINGTON

ORG_NAME: HOWARD UNIVERSITY

PHR: PROJECT NARRATIVE Building on the longstanding collaboration between Howard University (HU) and Johns Hopkins University (JHU), especially the Howard University Cancer Center (HUCC) and the JHU Sidney Kimmel Comprehensive Cancer Center (SKCCC), this application is to reignite the U54 CPACHE between the two institutions. The Howard-Johns Hopkins Comprehensive Alliance in cancer Research, Education, and Equity (H2CAREE) initiative is committed to the elimination of cancer health disparities in racial/ethnic minority and underserved populations in the DC, Maryland, and Virginia (DMV) region, particularly among African Americans. By leveraging the distinct yet complementary strengths and resources of the two institutions, we proposed rigorous and collaborative transdisciplinary research, research education, and outreach programs that will improve cancer care and health equity.

PI_NAMEs: KHAN, RAO ;LI, HENG ;WILLIAMS, CARLA D (contact);YATES, CLAYTON

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TERMS: Accreditation;Address;Administrative Supplement;Advanced Malignant Neoplasm;African American;African American population;African American student;anti-cancer research;Area;Baltimore;bioimaging;Biometry;Black race;Cancer Burden;cancer care;Cancer Center;cancer health disparity;Cancer Research Project;cancer type;Caring;Clinical;clinical practice;Clinical Trials;Collaborations;Collection;Communities;Complement;Comprehensive Cancer Center;Data Science;Development;Diagnosis;disparity elimination;District of Columbia;Diverse Workforce;Doctor of Philosophy;Early Diagnosis;Education;Education and Outreach;education research;Educational Status;Elderly;Epigenetic Process;Equity;Ethnic Origin;Ethnic Population;Etiology;Evaluation;Faculty;Foundations;Funding;Goals;Government;graduate student;Grant;health care disparity;Health Disparities Research;health disparity;health equity;high school;Historically Black Colleges and Universities;Hospitals;improved;innovation;Institution;Investments;Joints;Laboratories;Magnetic Resonance Imaging;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Maryland;Medical;Medical Students;Metformin;metropolitan;Minority;Minority Groups;Molecular;National Cancer Institute;novel;novel therapeutic intervention;Organizational Change;Outcome;outreach;outreach program;Paper;Patient Care;Patients;Phase;Physics;Pilot Projects;Population;Positioning Attribute;Postdoctoral Fellow;Prevention;Process;programs;proton therapy;Race;racial disparity;racial minority;randomized, clinical trials;recruit;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;response;Scientist;screening;Secure;socioeconomics;stem;Students;sustainable resource;traditional care;Training;Translational Research;ultra high resolution;undergraduate student;Underserved Population;United States National Institutes of Health;Universities;Virginia;Vision;Washington;Work

PROJECT_TITLE: 1/2 Howard - Hopkins Comprehensive Alliance in Cancer Research, Education, and Equity (H2CAREE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (A1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: WILLIAMS, CARLA D (contact)

PROJECT_TERMS: Address;Advisory Committees;anti-cancer research;Area;cancer health disparity;Collaborations;Communication;Comprehensive Cancer Center;Data;data integration;Data Science;Data Science Core;data sharing;Decision Making;Disparity population;Education;education research;Ensure;Equity;Evaluation;experience;Goals;Human Resources;improved;Institution;Institutional Review Boards;Lead;Leadership;Logistics;Manuscripts;Maryland;meetings;member;Minority Groups;Monitor;operation;outreach;outreach program;Preparation;Principal Investigator;programs;Quality Control;Research;Research Personnel;Research Project Grants;Resource Sharing;Safety;success;tool;Underserved Population;United States National Institutes of Health;Universities;Virginia;Work

PROJECT_TITLE: Overall


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: KWAGYAN, JOHN  (contact)

PROJECT_TERMS: analytical tool;anti-cancer research;Artificial Intelligence;base;Biometry;Cancer health equity;Cancer Research Project;Caring;Clinical;Code;cohort;Collaborations;Comprehensive Cancer Center;Data;data access;Data Commons;data curation;data handling;data infrastructure;data integrity;data management;data modeling;Data Reporting;data reuse;Data Science;Data Scientist;data sharing;Data Sources;data standards;Data Storage and Retrieval;Databases;Dedications;design;Development;Disparity;disparity reduction;Doctor of Philosophy;Economics;Education;education resources;Effectiveness;empowerment;Ensure;Environment;Equipment and supply inventories;Equity;Evolution;FAIR principles;Fostering;Geography;Goals;health care availability;health equity;health equity promotion;Healthcare;improved;Individual;Inequity;Infrastructure;infrastructure development;Institution;Lead;Libraries;Lytic;Machine Learning;Medical;Medical Records;meetings;Methodology;Modeling;Oncology;Patients;programs;public repository;Race;Recording of previous events;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;social;Software Engineering;Standardization;Statistical Data Interpretation;Statistical Methods;Structure;System;Technology;tool;Training and Education;Training Programs;Translations;Universities

PROJECT_TITLE: Data Science


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

PI_NAMEs: HUDSON, TAMARO SYTON (contact)

PROJECT_TERMS: Address;advanced prostate cancer;African American;African American population;African ancestry;anti-cancer research;ANXA2 gene;B-Lymphocytes;Biological;Biological Assay;Biological Markers;Biology;biomarker discovery;biomarker identification;biomarker validation;Biopsy;cancer health disparity;Cancer Patient;CDKN1B gene;Clinical;cohort;Collaborations;Complex;Cytoskeleton;Data;Data Set;density;Diagnosis;differences in access;Digestion;Disease;disorder risk;Disparity;Distant;Distant Metastasis;DNA Methylation;DNA Sequence Alteration;Education;epigenomic profiling;epigenomics;Equity;exome sequencing;FLNA gene;FLNC gene;follow-up;FOXP3 gene;Frequencies;Genes;Genetic;genomic profiling;Genomics;Health Disparities Research;Health Services Accessibility;high risk;HLA G antigen;Immune;improved;In Situ;Incidence;Joints;Knowledge;Link;Longterm Follow-up;lymph nodes;Malignant neoplasm of prostate;men;Metastatic Neoplasm to Lymph Nodes;Metastatic Prostate Cancer;Methylation;Molecular;molecular marker;multiple omics;Mutation;Neoplasm Metastasis;novel;Operative Surgical Procedures;Outcome;Pathologic;Pathway interactions;Patients;Pelvic lymph node group;Performance;Phenotype;Plasma Cells;Population;Portraits;Precipitation;precision medicine;predictive marker;Prevalence;Primary Neoplasm;Prognostic Marker;Proteins;Protocols documentation;PTEN gene;Race;Radical Prostatectomy;Regulatory T-Lymphocyte;Reproducibility;Research;restriction enzyme;Socioeconomic Status;Specimen;SPINK1 gene;Testing;The Cancer Genome Atlas;Tissues;TP53 gene;transcriptome sequencing;transcriptomics;tumor;tumor heterogeneity;tumor microenvironment;tumor progression;tumor registry;Tumor Tissue;tumor-immune system interactions;Universities;Validation;Work

PROJECT_TITLE: Molecular Determinants of Lethal Prostate Cancer in African-Americans


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

PI_NAMEs: AKALA, EMMANUEL O (contact)

PROJECT_TERMS: access disparities;Animal Model;Animals;anti-cancer research;Biocompatible Materials;Biodistribution;cancer therapy;Cells;Clinical;Clinical Pathways;clinical translation;cohort;Collaborations;contrast imaging;cost;curative treatments;Data;design;Development;Diagnosis;disparity reduction;Distant;Dose;Dose Limiting;Dose Rate;Drug Kinetics;Education;education research;Effectiveness;Equity;Faculty;Formulation;Goals;Health Services Accessibility;Hematology;Histopathology;Hypoxia;image guided;Immune;Immunocompetent;immunogenic;immunogenic cell death;Immunotherapy;immunotoxicity;Injections;innovation;Institution;Intestines;Investigation;Knowledge;Linear Energy Transfer;Logistics;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mentorship;Monkeys;Mus;nanoparticle;Neoplasm Metastasis;Normal tissue morphology;novel strategies;Organ;Oxygen;Pancreas;pancreatic neoplasm;Patients;Penetration;Pharmaceutical Preparations;Population;Prognosis;Protons;Publications;Publishing;Quality of life;Radiation therapy;Radioimmunotherapy;Renal function;Safety;side effect;Stomach;Survival Rate;System;systemic toxicity;Time;Tissues;Toxic effect;Treatment Efficacy;tumor;tumor ablation;tumor microenvironment;Tumor Volume;Universities;Visceral;Work

PROJECT_TITLE: Project #2


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

PI_NAMEs: DEH, KOFI  (contact)

PROJECT_TERMS: 3-Dimensional;Address;African American;African American population;anatomic imaging;Angiography;anti-cancer research;Arteries;bioprinting;Biopsy;Blood Tests;Blood Vessels;Cancer Prognosis;Castration;Caucasians;Cells;Chemical Dynamics;Chemicals;Clinical;cost;cost effective;Data;Death Rate;deep learning;Detection;detection method;Development;Diagnosis;Digital Rectal Examination;Dimensions;Disease;Disease Resistance;Disparity;Economics;Education;effectiveness evaluation;Energy Metabolism;Equity;Ethnic Population;experimental study;FOLH1 gene;generative adversarial network;Glucose;glucose metabolism;glucose uptake;hemodynamics;high resolution imaging;Histology;Image;image processing;Imaging Device;imaging modality;Imaging Techniques;improved;Incidence;Link;Liquid substance;Machine Learning;machine learning model;Magnetic Resonance Angiography;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Measurement;Measures;men;Metabolic;metabolic imaging;Metabolism;Methodology;Methods;Modeling;Molecular;mortality;mortality disparity;Mus;neural network;non-invasive imaging;optical imaging;Organ;Patients;Perfusion;Pilot Projects;predictive modeling;Prognosis;prostate biopsy;prostate cancer progression;Prostate-Specific Antigen;Prostatic Neoplasms;Protons;Recovery;Resolution;Sampling;screening;Screening for Prostate Cancer;Signal Transduction;simulation;Techniques;Technology;temporal measurement;Time;Tissues;tool;Tracer;Training;Transrectal Ultrasound;tumor;tumor progression;tumor xenograft;ultra high resolution;underserved community;Validation;Variant

PROJECT_TITLE: Pilot Project #1


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: GU, XINBIN  (contact)

PROJECT_TERMS: Advisory Committees;anti-cancer research;Area;cancer health disparity;Communities;Community Outreach;Data Analyses;Development;Education;Ensure;Equity;Evaluation;Event;Feedback;Fostering;Funding;Goals;Grant;Impact evaluation;Information Dissemination;insight;Institution;Joints;Logic;Malignant Neoplasms;Maryland;Methods;minority communities;Modeling;Monitor;Organizational Change;Outcome;Outcomes Research;outreach program;Principal Investigator;Process;process evaluation;Program Sustainability;programs;Publications;Recommendation;Reporting;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Resources;Series;Site;Students;System;Universities;Virginia;Work

PROJECT_TITLE: Planning and Evaluation


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: KHAN, RAO  (contact)

PROJECT_TERMS: Accreditation;Address;Advanced Malignant Neoplasm;African American;African American population;American;anti-cancer research;Area;Artificial Intelligence;black men;Black Populations;Black race;black women;cancer care;cancer health disparity;career;Caring;Clinical;Collaborations;computerized tools;Critical Thinking;Data;Data Science Core;data sharing;design;Diagnosis;disparity reduction;District of Columbia;Diverse Workforce;Doctor of Philosophy;Education;education research;Educational workshop;empowerment;Endometrial Carcinoma;Engineering;Equity;Ethnic Population;Faculty;Goals;graduate student;Health Sciences;high risk;high school;High School Student;Hospitals;improved;Incidence;innovation;Institution;interest;Joints;Laboratories;Link;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Maryland;Mathematics;Medical;Medicine;men;Mentors;Mind;Modernization;mortality;next generation;Outcome;outreach;Pathway interactions;Peer Review;Physics;programs;Publications;Publishing;racial disparity;racial population;recruit;Research;Research Personnel;Research Project Summaries;Research Training;Resources;Risk;Running;Science;Scientist;Sister;skills;socioeconomics;summer internship;symposium;Techniques;Technology;tool;Training;Training and Education;twelfth grade;Underrepresented Minority;Underrepresented Students;United States National Institutes of Health;Universities;Virginia;White Women

PROJECT_TITLE: Research Education


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Access to Information;Address;Advocacy;anti-cancer research;Applications Grants;Attention;Automobile Driving;Baltimore;Cancer Burden;cancer care;Cancer Center;cancer education;cancer health disparity;Cancer health equity;cancer risk;career;college;Communities;community academic partnership;community collaboration;community engaged research;community engagement;Community Health;community organizations;community partners;community partnership;community setting;community-centered;Comprehensive Cancer Center;design;Development;Diagnosis;Disparate;Disparity;disparity gap;disparity reduction;Economics;Education;Education and Outreach;education research;Educational Activities;Employment;Ensure;Equity;ethnic disparity;Ethnic Population;Evaluation;experience;Face;food insecurity;Foundations;frontier;Goals;graduate school;Grant Review;health care quality;health disparity;health equity;health inequalities;Health system;Healthcare;high school;High School Student;Housing;Individual;Inequity;innovation;Institution;Investments;Knowledge;Link;member;mortality;Nature;neighborhood disadvantage;Outcome;outreach;Pathway interactions;people of color;perceived discrimination;Politics;Positioning Attribute;Poverty;Prevention;Privatization;Process;programs;Public Health;racial disparity;racial population;Research;Research Personnel;Resources;Risk;Risk Reduction;Role;Scientific Advances and Accomplishments;screening;social;social determinants;socioeconomic disadvantage;Source;structural health determinants;Students;summer research;survivorship;Technology;Translating;trend;Trust;trustworthiness;Universities;Washington;Work;Youth

PROJECT_TITLE: Community Collaborations Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: SALISBURY

ORG_NAME: DRUG DELIVERY COMPANY, LLC, THE

ORG_STATE: MD

PHR: Project Narrative – “Relevance” The proposed research addresses the critical barrier of non-compliance with both oral NTX and XR-NTX that prevent these treatments from helping more patients with Opioid Use Disorder (OUD). A sustained release NTX implant that works for six to twelve months would likely improve compliance and prevent fatal respiratory depression and overdose deaths in addicts who relapse and inject opioids while in recovery, providing a “safety net” which will allow for mistakes in the recovery process without deadly consequences.

PI_NAMEs: BENNER, JEFFREY ;COHEN, STEVEN M (contact)

PROGRAM_OFFICER_NAME: SOUSA, JASON CARLOS

PROJECT_TERMS: addiction;Address;Animals;Autopsy;bevacizumab;Biocompatible Materials;biomaterial compatibility;Canis familiaris;Chemicals;Clinical Trials;Collection;Data;Data Analyses;design;Development;Devices;direct application;disability;Doctor of Philosophy;Dose;Drug Combinations;Drug Delivery Systems;Drug Formulations;Drug Implants;Drug Kinetics;efficacy evaluation;Encapsulated;Engineering;Evaluation;Excision;FDA approved;Fentanyl;Formulation;Gel;Glycolates;Goals;Good Clinical Practice;good laboratory practice;Health;healthy volunteer;Human;Implant;implant design;implantation;improved;In Vitro;in vivo;Injections;instrument;instrumentation;Internet;Interview;Investigational Drugs;Label;Life;liposomal formulation;Liposomes;Macular degeneration;Marketing;medication for opioid use disorder;Microspheres;Naltrexone;non-compliance;Operative Surgical Procedures;Opioid;opioid epidemic;opioid use disorder;Oral;overdose death;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase;phase 1 study;Phase I Clinical Trials;Phase II Clinical Trials;Placebos;Porosity;pre-clinical;pre-clinical research;preclinical development;preclinical safety;Preparation;prevent;Probability;problem drinker;Process;Proteins;Radio-Opaque;Rattus;Recovery;Regulatory Pathway;Relapse;relapse patients;Research;Rodent;Safety;safety net;safety study;safety testing;Serum;small molecule;subcutaneous;Techniques;Testing;Therapeutic;Toxic effect;Toxicology;United States;United States National Institutes of Health;Ventilatory Depression;Work

PROJECT_TITLE: A Long-Acting Bioabsorbable Naltrexone Subcutaneous Implant for Opioid Use Disorder


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Immunotherapy;Lung;Lung Cancer;Precision Medicine;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Malignant pleural mesothelioma (MPM) is a fatal tumor of the lining of the lungs that has defeated all traditional therapy. Emerging data on immune checkpoint inhibitors show that these drugs meaningfully prolong life in half of MPM patients that receive them, but at the cost of immune-related side effects. Using state-of-the-art techniques, this project tests conceptually innovative mechanisms by which MPM tumors (and potentially other human tumors) respond to these drugs, and our findings are used to develop a biomarker test which can identify patients who will benefit before they begin treatment.

PI_NAMEs: BURT, BRYAN MICHAEL (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: abstracting;Acceleration;anti-PD-1;antigen detection;Antigen Targeting;Architecture;Atlases;Bioinformatics;bioinformatics pipeline;Biological Markers;Biology;cancer therapy;Caring;cell type;Cells;chemotherapy;Clinical;clinical application;clinical biomarkers;Clinical Data;clinical translation;cohort;cost;cytokine;Cytometry;Data;design;Disease;effective therapy;Elements;exome sequencing;Formalin;Frequencies;high dimensionality;Human;human leukocyte antigen testing;Image;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;immunogenicity;Immunohistochemistry;Immunologics;improved;in silico;indexing;innovation;Life;Life Extension;Lung;Malignant Neoplasms;malignant pleura tumor;Malignant Pleural Mesothelioma;Mass Spectrum Analysis;Measures;MHC antigen;neoantigens;Nivolumab;novel;novel marker;Operative Surgical Procedures;Paraffin Embedding;Patient Care;Patients;PD-1 blockade;Peptides;Pharmaceutical Preparations;Phenotype;Pleura;predicting response;predictive marker;Production;programmed cell death ligand 1;prospective;Prospective cohort;prospective test;Protein Analysis;Proteins;Proteomics;Radiation therapy;Resistance;responders and non-responders;response;Sampling;side effect;Signal Transduction;single cell analysis;Specimen;standard of care;Structure;T cell response;T-Lymphocyte;Techniques;Testing;Time;time use;Tissues;Toxic effect;traditional therapy;transcriptome sequencing;Translating;Triage;tumor;Tumor Burden;tumor heterogeneity;tumor-immune system interactions;Validation

PROJECT_TITLE: Proteomic determinants of response to checkpoint blockade in malignant pleural mesothelioma

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Aging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Approximately 45% of adults age 18-64 are enrolled in high-deductible health plans, which require patients to pay for 100% of the costs of their healthcare until a (high) deductible is met. This study investigates whether these plans allow patients with chronic conditions sufficient healthcare access to manage their disease(s).

PI_NAMEs: MARSZOWSKI, RISHA GIDWANI (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: acute care;Address;Adult;Adverse event;Affect;Age;aged;Ambulatory Care;American;Asthma;burden of chronic illness;care costs;care seeking;Caring;Cessation of life;Chronic;Chronic Disease;Chronically Ill;Clinical Practice Guideline;cohort;Communities;Congresses;Coronary Arteriosclerosis;cost;Cost Sharing;cost shifting;COVID-19 pandemic;Data;Deductibles;design;Diabetes Mellitus;Disease;Disease Management;Disparity;Eligibility Determination;Enrollment;Ensure;Evaluation;evidence base;Exclusion;experience;Family;Gatekeeping;Gender;Goals;Guidelines;Health;health care availability;Health Care Costs;health care disparity;health care quality;health plan;Healthcare;healthy aging;Heart failure;Hypertension;Income;Individual;Insurance;Insurance Carriers;insurance plan;Investigation;Literature;Major Depressive Disorder;Measures;Medical;medically necessary care;Medicare;member;middle age;Modeling;National Institute on Aging;novel;Outcome;Outpatients;pandemic disease;Patients;Performance;Pharmaceutical Preparations;Policies;poor health outcome;Population;premature;prevent;Prevention Research;Preventive care;Privatization;Process;Quality of Care;Quasi-experiment;Race;racial disparity;Recommendation;Regulation;Research;response;secondary analysis;Services;sex;Shock;telehealth;Testing;Uninsured Medical Expense;Visit;Vulnerable Populations;waiver;Work

PROJECT_TITLE: High Deductible Health Plans and Receipt of Recommended Medical Care

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]