ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: ROCHESTER

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Narrative Bone infection caused by S. aureus remains the bane of orthopaedic surgery, as diagnostics, prophylaxis and treatments have significant shortcomings that result in catastrophic outcomes for patients, and crippling healthcare costs. To address this, we propose renewal of the Center of Research Translation on the Osteoimmunology of Bone Infection (CoRTOBI), which will increase our knowledge on pathogenesis and immunity, and develop novel diagnostics and interventions for patients with serious bone infections.

PI_NAMEs: SCHWARZ, EDWARD M. (contact)

PROGRAM_OFFICER_NAME: GREEN PARKER, MELISSA C

PROJECT_TERMS: 3-Dimensional;3D Print;Address;Adjuvant;adverse outcome;Advisory Committees;Algorithms;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Antigens;antimicrobial;Award;Bioinformatics;Biological Assay;Biometry;bone;Center for Translational Science Activities;Chemicals;Clinic;Clinical;clinical candidate;clinical translation;Collaborations;Community Outreach;Consensus;COVID-19 pandemic;Custom;demographics;Development;Diagnosis;Diagnostic;Educational workshop;Event;Fostering;Funding;Gene Expression Regulation;Genetic;genetic strain;Genomics;Goals;Health Care Costs;Human;Image;Immune;Immune Evasion;Immune response;Immunity;Immunoassay;Immunodiagnostics;Implant;imprint;in vivo imaging;Incidence;industry partner;ineffective therapies;Infection;infection rate;innovation;innovative technologies;Intellectual Property;Interest Group;International;Intervention;intravital microscopy;Invaded;Knowledge;Legal patent;meetings;microbial;Microfabrication;Molecular;mouse model;Mus;Musculoskeletal;novel;novel diagnostics;Operative Surgical Procedures;ORALIT;Orthopedic Surgery;Orthopedics;Osteocytes;osteoimmunology;Osteomyelitis;Outcome;Outcome Measure;outreach program;Pathogenesis;Pathogenicity;Patient risk;Patient-Focused Outcomes;Patients;Periprosthetic joint infection;Persons;Predisposition;prevent;programs;prophylactic;Prophylactic treatment;Proteome;Publications;Race;Replacement Arthroplasty;Research;Research Personnel;Research Project Grants;response;RNA vaccine;Seminal;small molecule inhibitor;standard of care;Staphylococcus aureus;Staphylococcus aureus infection;success;Surface;technological innovation;Technology;Testing;Therapeutic;Time;Translating;Translations;Vaccines;Virulent;Work


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative Telomerase-negative cancer cells that use an alternative lengthening of telomeres (ALT) pathway for telomere maintenance have many unique nuclear features including the relocation of nuclear bodies to telomeres, telomere clustering, and formation of unique RNA foci on telomeres. These unique features are used for ALT diagnosis but how they contribute to ALT cancer is unknown. By combining expertise in nuclear organization and ALT cancer, we will test a liquid-liquid phase separation model for the formation and function of these unique features, providing potential to target these features for ALT cancer therapy.

PI_NAMEs: ZHANG, HUAIYING  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: 3-Dimensional;Acute Promyelocytic Leukemia;Adopted;Behavior;Biological Markers;Body Composition;cancer cell;Cancer Cell Growth;cancer therapy;Cell Nucleus;Cell Physiology;Cell Proliferation;Cells;Chromosome Structures;Collaborations;Cultured Cells;Diagnosis;DNA biosynthesis;DNA Repair;Exhibits;Gene Expression;Genome;homologous recombination;Human;Immune response;insight;Knowledge;Label;Length;Liquid substance;Malignant Neoplasms;Mechanics;Microscopy;Modeling;Molecular;Monitor;Nature;novel therapeutics;Nuclear;optogenetics;Phase;Phenotype;Physical condensation;prevent;Process;Proteins;recruit;repaired;RNA;RNA-Binding Proteins;RNA-Directed DNA Polymerase;segregation;side effect;single molecule;Structure;superresolution microscopy;Telomerase;Telomerase inhibition;telomere;Telomere Maintenance;Telomere Pathway;Testing;therapeutic development;therapeutic target;Tissues;tool;Untranslated RNA;Visualization

PROJECT_TITLE: Phase separation-induced nuclear organization in ALT Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(71)R]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_STATE: NY

PROJECT_TERMS: 3D Print;Acceleration;Address;Adjuvant;Advisory Committees;Algorithms;Antibiotic Therapy;Antibiotics;Antigens;Award;Biochemistry;Biocompatible Materials;Biology;Biomechanics;Biometry;bone;Center for Translational Science Activities;Clinic;Clinical;Clinical Research;Collaborations;commercialization;Communicable Diseases;Communication;Communities;Community Outreach;Consensus;cortical bone;cost effective;Custom;Dedications;demographics;Diagnosis;drug discovery;Educational workshop;Evaluation;Event;Fostering;Funding;Genetic;Goals;Histology;Human Resources;Immune;Immunity;Immunoassay;Immunology;Immunosuppression;Implant;imprint;improved;in vivo imaging;Incidence;industry partner;ineffective therapies;Infection;infection rate;Intellectual Property;International;Legal patent;Licensing;materials science;Medicine;meetings;Messenger RNA;microbial;molecular imaging;multimodality;Mus;Musculoskeletal;nanoparticle;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;ORALIT;Orthopedic Surgery;Orthopedics;Osteocytes;osteoimmunology;Osteomyelitis;Outcome;Pathogenesis;Pathology;Patients;Periprosthetic joint infection;Persons;Pilot Projects;Predisposition;prevent;Prevention;Prognosis;programs;Proteome;Publications;Quality Control;Race;Replacement Arthroplasty;Research;Research Personnel;Resources;response;Running;Schedule;Seminal;Services;Small Business Innovation Research Grant;standard of care;Staphylococcus aureus;Staphylococcus aureus infection;Structure;success;Surface;Surgeon;synergism;Technology;Testing;Time;Tissue Engineering;Tissue imaging;Translating;United States National Institutes of Health;Universities;Vaccines;virtual;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: LOS ANGELES

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Vision science is entering a phase where many `untreatable' blinding diseases will become amenable to treatment, given further research. However, the development of breakthrough therapies will require a new generation of vision scientists with broad experience in the areas of stem-cell technology, gene delivery, biochemical pathogenesis, and functional analysis. The Vision Science Training Program (VSTP) at the Stein Eye Institute, with its world-class faculty and outstanding facilities, seeks to continue training leaders in the field of vision science.

PI_NAMEs: SAMPATH, ALAPAKKAM P (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Training Programs;vision science

PROJECT_TITLE: Vision Science Training Program


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases

ORG_CITY: GRAND FORKS

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

ORG_STATE: ND

PHR: Narrative The North Dakota Flow Cytometry and Cell Sorting (ND-FCCS) Core provides investigators consultation in the design of fluorescent cell analysis or sorting experiments including fluorochrome selection and parameter calibration; training and oversight on the instrumentation to collect flow cytometry data; flow cytometric cell sorting; consultation on data analysis and usage of analysis software; as well as maintenance, upkeep, and when appropriate, upgrading of the instrumentation and analysis software. The Core will initiate full service for those investigators wanting the Core to perform the collection of flow cytometric data on their prepared/stained cells, as well as continued fluorescent cell sorting. To ensure ongoing sustainability, a fee for service or instrument usage fee will be implemented during the Phase 2 period of the COBRE for all users of the Core.

PI_NAMEs: BRADLEY, DAVID S. (contact)

PROJECT_TERMS: Advisory Committees;Applications Grants;Biomedical Research;Biotechnology;Calibration;cell preparation;Cell Separation;Cells;Centers of Research Excellence;Collection;Communicable Diseases;Compensation;Computer software;Consultations;Data;Data Analyses;Dedications;design;Educational workshop;Ensure;Experimental Designs;experimental study;Fee-for-Service Plans;Fees;Floor;Flow Cytometry;Fluorochrome;Funding;Human;Immunology;Institution;Instruction;instrument;instrumentation;Laboratories;Licensing;Maintenance;Malignant Neoplasms;manufacture;medical schools;member;Microbiology;North Dakota;nutrition;operation;pathogen;Pathology;Periodicals;Phase;Research Personnel;Schedule;Services;Site;Software Design;Sorting;Stains;Training;United States Department of Agriculture;Universities;Update;webinar

PROJECT_TITLE: Flow Cytometry Core


PI_NAMEs: MILLER, BENJAMIN L (contact)

PROJECT_TERMS: 3-Dimensional;Adhesions;Antibiotic Resistance;Antibiotics;Antibodies;antibody diagnostic;assay development;Behavior;Biological Assay;Biophysics;bone;Cells;Center for Translational Science Activities;Chronic;Clinical;clinical diagnostics;Collaborations;Communicable Diseases;cortical bone;cost efficient;cytokine;Development;Devices;Drug Screening;Electron Microscopy;Emerging Technologies;Engineering;experience;Funding;Future;Goals;Hematopoietic;Host Defense;Human;Image;Immune;Immunoassay;Immunology;Immunology procedure;Implant;In Vitro;Infection;innovation;innovative technologies;Institution;Intervention;intravital microscopy;Invaded;Laser Scanning Microscopy;Legal patent;materials science;Measurement;Membrane;Methods;microbial;Microfluidics;microscopic imaging;Monoclonal Antibodies;multi-photon;multidisciplinary;multiplex assay;Musculoskeletal;Nanoporous;new technology;novel;Occupations;ORALIT;Orthopedic Surgery;Osteocytes;osteoimmunology;Osteomyelitis;Outcome;Passive Immunotherapy;Pathogenesis;Pathology;Patients;Process;prognostic;programs;Proteome;Protocols documentation;Publications;Publishing;Race;Research;Research Personnel;Resources;Risk Factors;RNA vaccine;Sampling;Serum;Services;Silicon;Staphylococcal Infections;Staphylococcus aureus;Surface;surface coating;Technology;technology development;Testing;Three-Dimensional Imaging;Time;tool;Translating;vaccine trial

PROJECT_TITLE: Osteoimmunology Core


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases

PI_NAMEs: AWAD, HANI A (contact)

PROJECT_TERMS: 3D Print;Adhesions;Adjuvant;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Antimicrobial Resistance;Bacteria;Bacterial Adhesins;Biological Process;bone;bone healing;Candidate Disease Gene;Cell division;Cell Wall;cellular targeting;Center for Translational Science Activities;Chemicals;Chronic;chronic infection;Clinical;Communities;cortical bone;cost;Cues;design;Disease;Dose;efficacy validation;Femur;Funding;Gene Expression;Gene Expression Regulation;Genes;Genetic Determinism;Genomics;high throughput screening;Hospitals;Immune Evasion;Implant;In Vitro;in vivo;Infection;inhibitor;Intervention;Invaded;Libraries;Local Therapy;Membrane;methicillin resistant Staphylococcus aureus;Methods;microbial;microchip;Microfluidics;migration;Minimum Inhibitory Concentration measurement;Modeling;Molecular;Molecular Genetics;Motility;mouse model;Mus;Musculoskeletal;mutant;nanomembrane;novel;novel therapeutic intervention;Operative Surgical Procedures;Osteocytes;osteoimmunology;Osteomyelitis;Outcome;Pathway interactions;Patients;Penicillin Binding Protein 4;Peptidoglycan;Peptidyltransferase;Polymethyl Methacrylate;Predisposition;Process;programs;Prophylactic treatment;Proteins;Recurrence;recurrent infection;Refractory;Replacement Arthroplasty;resistance mechanism;response;Rod;Role;scaffold;screening;Second Look Surgery;Shapes;Silicon;small molecule;small molecule inhibitor;Specificity;Staphylococcus aureus;Staphylococcus aureus infection;submicron;Surface;Systemic Therapy;Techniques;Testing;Therapeutic;therapeutic candidate;transcriptome sequencing;translational impact;Translations;Vancomycin;Work

PROJECT_TITLE: Elucidating the Mechanisms of S. aureus Motility in Bone and Developing Interventions


ORG_CITY: ALBUQUERQUE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: Project Narrative The University of New Mexico (UNM) FIRST program will hire a diverse cohort of early career faculty in the areas of neuroscience and data science and transform UNM’s institutional culture towards sustained inclusive excellence. The recruitment, promotion, and retention of the UNM FIRST faculty cohort will diversify the biomedical faculty workforce at UNM where diverse faculty representation will offer role models for female and underrepresented minority (URM) trainees who will be the next generation of URM NIH-funded scientists. Through the ongoing efforts of the UNM leadership and UNM institutional commitments, the UNM FIRST program will also systemically transform the UNM culture towards inclusive excellence in a Hispanic Serving Institution that is also a Carnegie Very High Research Activity institution located within a majority-minority state.

PI_NAMEs: SALINAS, IRENE ;SMITH, JANE ELLEN  (contact)

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Academia;Administrator;Aging;Alaska Native;American Indians;Area;Arts;Award;career;cohort;college;Communities;community building;computational neuroscience;Data Science;Development;Disadvantaged;Disadvantaged minority;diversity and inclusion;early-career faculty;Education;Ensure;equity, diversity, and inclusion;Evaluation;Evidence based practice;experience;Faculty;Female;Fostering;Funding;Goals;Hispanic;Hispanic-serving Institution;innovation;Institution;Institutional Policy;interest;Job Satisfaction;Leadership;Legitimacy;life span;longitudinal design;member;Mentors;Methods;Minority;minority trainee;Mission;Modeling;Monitor;Nervous System Disorder;neurochemistry;neurodevelopment;neuroimaging;Neurosciences;New Mexico;next generation;Outcome;Policies;Policy Making;Population;precision medicine;Principal Investigator;programs;Race;Records;recruit;Research;Research Activity;Research Personnel;Rest;role model;Science;Scientist;Secure;success;Teacher Professional Development;tenure track;Training;Underrepresented Minority;United States;United States National Institutes of Health;Universities;Woman;Women's Group;Work

PROJECT_TITLE: UNM FIRST: Promoting Inclusive Excellence in Neuroscience and Data Science


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Infectious Diseases;Networking and Information Technology R&D (NITRD)

PHR: NARRATIVE The HPI COBRE is proposing a new Computational Data Analysis Core (CDAC) in the Phase 2 application to support the big data analysis needs of the new project leaders and the larger UND research community. CDAC will provide dedicated state-of-the-art and accurate high-throughput data analysis services, which will significantly enhance the research of COBRE investigators.

PI_NAMEs: HUR, JUNGUK  (contact)

PROJECT_TERMS: analysis pipeline;Area;Behavior;Big Data;Bioinformatics;Biological;biological systems;Biomedical Research;career;Cells;Centers of Research Excellence;ChIP-seq;Communities;Complex;computational platform;Computer software;Computing Methodologies;Consultations;Data;Data Analyses;data analysis pipeline;data integration;data mining;Data Science;Databases;Dedications;design;diverse data;DNA Methylation;Educational Activities;Educational process of instructing;Educational workshop;Ensure;Epigenetic Process;experience;Experimental Designs;Faculty;Genomics;Goals;graduate student;Grant;high throughput analysis;high throughput technology;innovation;Learning;lipidomics;Measures;member;metabolomics;Metagenomics;Methodology;Methylation;microbiome sequencing;Organism;pathogen;Pathway interactions;Phase;Postdoctoral Fellow;Property;Proteomics;Research;Research Personnel;Resources;Ribosomal RNA;Role;Science;Services;single molecule;single-cell RNA sequencing;skills;Standardization;Students;System;Systems Biology;Technology;tool;Training;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Computational Data Analysis Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Immunization;Infectious Diseases;Nanotechnology;Prevention;Rare Diseases;Vaccine Related

PROJECT_TERMS: adaptive immunity;adverse outcome;Animal Model;Antibodies;Antigens;B-Lymphocytes;Biological Assay;biomarker validation;Blood;Bone Marrow;Center for Translational Science Activities;Clinical;comorbidity;COVID-19 pandemic;Custom;Defect;DNA sequencing;Dose;Emergency Department patient;experience;Funding;Genes;genome sequencing;Glucosaminidase;Goals;Immune;Immunoassay;Immunoglobulin-Secreting Cells;Immunologic Tests;Immunologics;Implant;Infection;Infection Control;infection rate;Integration Host Factors;Iron;Messenger RNA;methicillin resistant Staphylococcus aureus;Methods;Modeling;Monoclonal Antibodies;mouse model;Mus;nanoparticle;Nomograms;Odds Ratio;Operative Surgical Procedures;Orthopedic Surgery;osteoimmunology;Osteomyelitis;Outcome;Paper;pathogen;Patients;Persons;Plasma Cells;Plasmablast;Population;Prediction of Response to Therapy;Predisposition;prognostic;prophylactic;Prophylactic treatment;Proteome;Registries;Research;response;Risk Factors;RNA vaccine;Role;Staphylococcus aureus;Staphylococcus aureus infection;success;Technology;Testing;Therapeutic;Time;Trauma;vaccine candidate;Vaccines;virtual;Virulence Factors;Virulent;whole genome;Work

PROJECT_TITLE: Defining the Protective vs. Susceptible Immune Proteome of S. aureus Osteomyelitis


ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: The University of Maryland School of Medicine (UMSOM) and the University of Maryland Baltimore County (UMBC) are submitting a joint application to the NIH Faculty Institutional Recruitment for Sustainable Transformation (FIRST) program to recruit new faculty members from groups traditionally underrepresented (UR) in biomedical research. This consortium will use a model for faculty development and promotion that is based on the UMBC Meyerhoff Scholars Program, which has been highly in training undergraduates from UR groups who have gone on to careers in STEM (Science, Technology, Engineering, Medicine). The model will feature cluster hires of 10 new faculty in the areas of cancer biology, neuroscience and microbiology/immunology/infectious diseases, in which there is great institutional strength.

PI_NAMEs: KAPER, JAMES B (contact);LACOURSE, WILLIAM RICHARD

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Academy;Affect;Appointment;Area;Baltimore;Biomedical Research;Cancer Biology;career;Climate;cohort;Communicable Diseases;Communities;County;Dedications;design;Development;Educational process of instructing;Engineering;Ensure;Environment;Evaluation;experience;Faculty;faculty mentor;Fostering;Funding;Future Generations;Goals;Immunology;Individual;Infrastructure;Institution;Institutional Policy;Joints;Link;Maryland;medical schools;Medicine;member;Mentors;Microbiology;Modeling;Monitor;Neurosciences;Postdoctoral Fellow;Procedures;Process;Productivity;professor;programs;Qualifying;Readiness;recruit;Research;Research Personnel;Resources;role model;Scholars Program;Schools;Science;Series;Services;skills;suburb;success;Teacher Professional Development;Technology;tenure track;Textiles;Training;Training Programs;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: University of Maryland FIRST Program


PI_NAMEs: SMITH, JANE ELLEN  (contact)

PROJECT_TERMS: Adopted;Aging;American Indians;Area;Arts;Career Mobility;cohort;college;Communities;computational neuroscience;Data;Data Science;Department chair;design;Development;Development Plans;Discrimination;Ethnic Origin;Evaluation;evidence base;Faculty;Female;Funding;Goals;Graduate Enrollment;graduate student;Grant;Health;Hispanic;Hispanic-serving Institution;Human;improved;Individual;innovation;Institution;Institutionalization;interest;International;Lead;Leadership;life span;Mentors;Minority;minority scientist;minority trainee;Mission;model design;Modeling;Nervous System Disorder;neurochemistry;neurodevelopment;neuroimaging;Neurosciences;New Mexico;next generation;Outcome;Policies;Population;Positioning Attribute;precision medicine;Principal Investigator;Process;programs;racial diversity;recruit;Research;Research Activity;Research Personnel;Resources;role model;Science;Scientist;Students;success;Teacher Professional Development;tenure track;Testing;Training;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: UNM FIRST: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MOSS-R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: COLUMBIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Although diversity is a well-recognized driver of research innovation, biomedical research institutions have often failed to effectively incorporate minoritized groups. In partnership with the University of South Carolina’s leadership, this project will transform institutional policies, practices, and culture toward inclusive excellence with the aim of creating inclusive environmental change and in the process supporting a cohort of 10 tenure- track Assistant Professors. The results of this research will yield best practices and evidence-based models for institutional transformation toward inclusive excellence.

PI_NAMEs: FELDER, TISHA ;LIESE, ANGELA D (contact)

PROJECT_TERMS: Accountability;Address;African American;Area;Attitude;Biomedical Research;Black race;Businesses;Climate;cohort;Collaborations;Collection;college;Communities;Complement;Creativeness;Development;Development Plans;Discipline of Nursing;diversity and inclusion;early-career faculty;Effectiveness;Elements;Ensure;Environment;environmental change;Equity;equity, diversity, and inclusion;Ethnic Origin;Evaluation;evidence base;experience;Faculty;faculty mentor;Goals;Grant;health disparity;Health equity research;Health Sciences;improved;Incentives;Incubators;Individual;Infrastructure;innovation;Institution;Institutional Policy;Institutional Practice;Institutional Racism;instrument;Intervention;Leadership;Lesbian Gay Bisexual Transgender Queer Questioning;Letters;Link;Measures;Mentors;Minority;Minority Groups;Minority Recruitment;Modeling;Nationalities;peer;people of color;Persons;Policies;Process;professor;programs;Public Health Schools;Questioning individuals;Race;Recording of previous events;recruit;Research;Resources;response;Science;Sex Bias;South Carolina;Sterile coverings;Strategic Planning;success;Surveys;System;Teacher Professional Development;tenure track;Training;Universities;Woman;working group

PROJECT_TITLE: Faculty Initiative for Improved Recruitment, Retention, and Experience (FIIRRE)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences;Physical Activity;Sleep Research

ORG_CITY: LARAMIE

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: Circadian disruption can lead to many deleterious health outcomes including cardiovascular disease, stroke, and metabolic syndrome. Furthermore, the International Agency for Research on Cancer, has declared night shift work detrimental to human health, based on “the potential for circadian disruption to contribute to the etiology of cancer or other diseases”. Identifying ways to mitigate the harmful consequences that arise from circadian disruption negatively impacting human health is imperative.

PI_NAMEs: SCHMITT, EMILY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: KRASNOVA, IRINA N

PROJECT_TERMS: Biology;Cancer Etiology;Cardiovascular Diseases;Centers of Research Excellence;Chronic;circadian;Circadian desynchrony;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Coupling;Darkness;Disease;Exercise;experimental study;Goals;Health;Human;International Agency for Research on Cancer;Light;Mediator;Metabolic syndrome;Modeling;Molecular;molecular clock;Mus;Neurons;neuropeptide Y;Outcome;Pathway interactions;Pattern;Peripheral;Phase;Pilot Projects;Publishing;Qualifying;receptor;Reporting;Rodent Model;Role;Science;Sensory;Serotonin;shift work;Stroke;Testing;tool;transcriptome sequencing;Work;Wyoming

PROJECT_TITLE: The Role of Exercise in Controlling Central Mediators of Circadian Rhythm


ORG_CITY: CHICAGO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The Northwestern University Recruitment to Transform Under-Representation and achieve Equity (NURTURE) Program will employ a faculty cohort model to enhance the diversity of tenure-track biomedical research faculty at Northwestern (NU) and enhance an institutional culture of inclusive excellence. There is substantial institutional support allowing 15 tenure-track faculty to be hired, as an addition to complementary institutional initiatives. NURTURE introduces several innovations aimed at ensuring the success of the individuals that will be hired, contributing along with other non-overlapping efforts to transforming the culture of the institution to recognize, promote, and celebrate the scientific, social, and cultural benefits of inclusive excellence.

PI_NAMEs: PERREAULT, ERIC JON;SIMON, MELISSA A. (contact);YANCY, CLYDE W.

PROJECT_TERMS: Academia;Acceleration;Accountability;Area;Automobile Driving;Award;Behavior;Biomedical Research;Brain;built environment;Businesses;Cardiovascular system;career;career development;Cells;cohort;Collaborations;combat;Communities;community building;Development;diversity and inclusion;empowerment;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;experience;Face;Faculty;Faculty Recruitment;faculty support;Fostering;Foundations;Funding;Goals;Growth;Health;Heart;Human;improved;Individual;innovation;Institution;Institutional Racism;Investments;Leadership;Learning;Left;Letters;Malignant Neoplasms;member;Mentors;Mentorship;Mind;Minority-Serving Institution;Mission;Modeling;Neighborhoods;parity;Persons;Policies;Positioning Attribute;post-doctoral training;Process;programs;racism;rate of change;Records;recruit;Research;research faculty;Research Personnel;Scholarship;Schools;Science;Scientist;Self Efficacy;social;Societies;Structure;Students;success;Sum;synergism;System;systemic barrier;Teacher Professional Development;tenure track;Testing;Time;Training Programs;Underrepresented Populations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: NURTURE: Northwestern University Recruitment to Transform Under-Representation and achieve Equity


NIH_SPENDING_CATS: Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences

PI_NAMEs: SALINAS, IRENE  (contact)

PROJECT_TERMS: Acceleration;Achievement;Administrator;Advisory Committees;Arts;Award;Biomedical Research;career;Career Choice;career development;Categories;cohort;college;Communities;community based research;community building;Data Science;Department chair;Development;Development Plans;Disadvantaged;Disadvantaged minority;Diverse Workforce;early-career faculty;Ensure;Environment;equity, diversity, and inclusion;Ethnic Population;Evaluation;Event;Extramural Activities;Faculty;faculty research;faculty support;Female;Fostering;Foundations;Funding;Future;Goals;Health;Hispanic;Hispanic-serving Institution;Home;Hour;Human;improved;Individual;innovation;Institution;Institutionalization;International;Leadership;Legitimacy;Love;Maps;marginalization;meetings;Mentors;Minority;Mission;Neurosciences;New Mexico;peer;peer coaching;Policies;preservation;Process;programs;racial population;recruit;Research;Research Activity;research and development;Research Personnel;Research Support;Resource Development;role model;Science;Secure;Series;skill acquisition;social;STEM field;success;Teacher Professional Development;Time;Training;Underrepresented Minority;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: UNM FIRST: Faculty Development Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Pediatric

PHR: Project narrative Diarrheal diseases remain the second leading cause of mortality in children younger than 5 years old worldwide, leading to 1.3 million deaths per year. This proposal seeks to identify novel targets in the immune system that can be targeted for the development of novel therapeutics against intestinal infections caused by a wide range of pathogens.

PI_NAMEs: SOLAYMANI-MOHAMMADI, SHAHRAM  (contact)

PROJECT_TERMS: 5 year old;Abdominal Cramps;Adoptive Transfer;Anatomy;Bile Acids;Catabolism;CCL20 gene;CCR6 gene;CD4 Positive T Lymphocytes;Celiac Disease;Cell Separation;Cells;Cessation of life;Characteristics;chemokine;chemokine receptor;Child;Cholesterol;Circulation;Citrobacter rodentium;Clinical;Colon;Cues;Cyst;cytokine;Developing Countries;Development;Diarrhea;diarrheal disease;differential expression;Duodenum;effector T cell;Enteral;enteric infection;enteric pathogen;Epithelial Cells;Failure to Thrive;Flatulence;Food Contamination;gastrointestinal symptom;Giardia;Giardiasis;Growth;gut inflammation;Homing;Human;human model;Immune;Immune response;Immune system;Immunity;Immunocompetent;Impairment;imprint;improved;in vivo;Individual;Infection;Ingestion;insight;interleukin-21;interleukin-21 receptor;intestinal epithelium;intestinal homeostasis;Intestines;jejunum;Lamina Propria;Lymphocyte;Malabsorption Syndromes;Mediating;migration;mortality;mouse model;Mucosal Immunity;Mucous Membrane;Mus;Nausea;novel;novel therapeutics;Parasites;pathogen;Play;Prevalence;Preventive;Production;Protozoan Infections;receptor;receptor binding;recruit;Regulation;Role;Route;Shapes;Signal Pathway;Signal Transduction;Small intestine mucous membrane;Small Intestines;STAT protein;STAT3 gene;Surface;T-Lymphocyte;Testing;therapeutic target;trafficking;Up-Regulation;Water

PROJECT_TITLE: Project 2


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Narrative Our understanding of cell-based processes, our ability to replicate and perturb biological systems in vitro, and the potential to engineer tissue replacements for clinical use depends on our abilities to engineer tissue constructs that achieve the cell densities and biological complexity seen in vivo and that, critically, include vascular support to support cells’ metabolic functioning. This proposal will develop and apply biofabrication methods that enable the precise positioning of cells and materials within highly vascularized constructs in building models of biology, development, and disease as well as in designing replacement tissue. The work in this proposal should have broad impact on our work to understand fundamental biological and medical questions, on our abilities to develop tissue models in vitro used in understanding and treating disease, and on capabilities to engineer replacement tissue for clinical use.

PI_NAMEs: HIGHLEY, CHRISTOPHER B (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: 3-Dimensional;Address;Adult;Applied Research;Behavior;Biochemical;Biocompatible Materials;biofabrication;Biological;biological systems;Biology;Biomechanics;Biomimetics;Biophysics;bioprinting;Blood Vessels;Cell Communication;Cell Density;Cell model;Cell Physiology;Cells;Clinical;Complex;Cues;design;Development;Disease;Disease Progression;Engineering;Environment;experience;Goals;Hydrogels;In Vitro;in vitro Model;in vivo;innovation;Medical;meetings;Metabolic;Methods;model building;Modification;Organ Transplantation;Organism;Patients;Phenotype;Population;Positioning Attribute;Process;replacement tissue;Research;Resolution;response;Signal Transduction;Specific qualifier value;Stimulus;Structure;Supporting Cell;System;Technology;Therapeutic;Therapeutic Uses;three dimensional structure;Time;Tissue constructs;Tissue Engineering;Tissue Model;Tissues;translational medicine;Translational Research;two-dimensional;Vascularization;Work

PROJECT_TITLE: Building biophysical and biochemical complexity in 3D cell and tissue constructs


NIH_SPENDING_CATS: Clinical Research;Data Science;Dissemination and Implementation Research;Neurosciences

PI_NAMEs: WITKIEWITZ, KATIE A (contact)

PROJECT_TERMS: Biomedical Research;Climate;cohort;Collaborations;Common Data Element;Communication;Conflict (Psychology);Data;Data Collection;Data Science;design;Development;diversity and inclusion;Effectiveness;Evaluation;Evidence based practice;experience;Faculty;faculty support;Foundations;Funding;Goals;Hispanic-serving Institution;implementation evaluation;implementation framework;implementation science;Individual;innovation;Institution;Leadership;Measurement;Measures;Mentors;Methods;Minority;Modeling;Monitor;multilevel analysis;Neurosciences;New Mexico;organizational climate;Outcome;Perception;Population;primary outcome;Process;Program Evaluation;programs;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Activity;Research Personnel;Research Support;satisfaction;Science;Self Perception;Self-reflection;STEM field;STEM research;Students;success;System;Teacher Professional Development;Testing;Time;Transcend;Trust;Underrepresented Minority;United States National Institutes of Health;Universities;Vision;Woman;Work

PROJECT_TITLE: UNM FIRST: Evaluation Core


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: KAPER, JAMES B (contact)

PROJECT_TERMS: Affect;Area;Baltimore;Biomedical Research;biomedical scientist;Cancer Biology;career;career development;cohort;Collaborations;Communicable Diseases;County;diversity and inclusion;Engineering;Ensure;Environment;equity, diversity, and inclusion;Evaluation;evidence base;expectation;experience;Faculty;faculty mentor;Faculty Recruitment;faculty support;Federal Government;Funding;Future;Goals;high school;Immunology;Individual;Infrastructure;Institution;Institutional Policy;Joints;junior high school;Leadership;Learning;Legal Rights;Maryland;Medical;medical schools;Medicine;member;Microbiology;Modeling;Monitor;Neurosciences;novel;outreach;Pathway interactions;Philosophy;Positioning Attribute;Postbaccalaureate;Procedures;Process;process improvement;professor;programs;Racial Equity;Recording of previous events;recruit;Research Personnel;Resources;Role;Scholars Program;Science;Series;Social Justice;sound;State Government;State Interests;Statutes and Laws;success;System;Talents;Teacher Professional Development;Technology;tenure track;Textiles;Thinking;tool;Training;Translating;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Vision

PROJECT_TITLE: Administrative Core-UM First


PI_NAMEs: LIESE, ANGELA D (contact)

PROJECT_TERMS: Accountability;Adoption;Advocate;Area;Award;Cell Nucleus;cohort;Collaborations;college;Communities;Decision Making;Discipline of Nursing;Discrimination;diversity and inclusion;early-career faculty;Education;Elements;Ensure;equity, diversity, and inclusion;Evaluation;experience;Faculty;Faculty Recruitment;Fostering;Funding;Goals;health disparity;health equity;Health equity research;Health Sciences;Human Resources;improved;Incentives;Individual;Infrastructure;innovation;Institution;Investments;Leadership;Mentors;Minority;operation;organizational structure;outreach;Policies;policy recommendation;Positioning Attribute;Process;professor;programs;Public Health Schools;racial bias;racism;Recommendation;recruit;Research;Research Personnel;Resources;Schools;Science;Secure;sociodemographics;South Carolina;Sterile coverings;Strategic Planning;Students;success;System;tenure track;United States National Institutes of Health;Universities

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MOSS-X]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Heart Disease;Hematology;Infectious Diseases;Lung

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The goal of the proposed Alliance is to employ late-stage implementation research strategies to deliver proven- effective interventions for heart, lung, blood, and sleep comorbid diseases and disorders in people living with HIV in low and middle-income countries (LMICs). In support of that goal, our Research Coordinating Center will provide scientific, organizational, statistical, quality control, capacity building and operational leadership. We will do so using a carefully assembled investigative team that has extensive experience and expertise coordinating large multicenter clinical and epidemiologic research projects, in dissemination and implementation research, organizing and implementing training programs in LMICs, and in the critical domains of biostatistics, research design, HIV/AIDS, and non-communicable diseases.

PI_NAMEs: DAVILA-ROMAN, VICTOR G.;GENG, ELVIN H.;RICE, TREVA K.;SCHECHTMAN, KENNETH B. (contact)

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: Aging;antiretroviral therapy;Bioinformatics;Biometry;Blood;Caring;Chronic Disease;Clinical;Clinical Research;cohort;Collaborations;Communication;comorbidity;Companions;Country;Data;Data Analyses;data harmonization;data management;Data Protection;data quality;design;Development;Diagnosis;Disease;Disease Management;Disease Progression;disorder control;Dissemination and Implementation;Educational process of instructing;effective intervention;efficacious treatment;Ensure;Epidemic;Epidemiology;epidemiology study;experience;Foundations;Funding;Funding Opportunities;global health;Goals;health care delivery;health economics;Health Policy;Health system;Heart;Heart Diseases;Hematological Disease;HIV;HIV/AIDS;Human Resources;implementation context;implementation outcomes;implementation research;implementation science;implementation strategy;Infrastructure;insight;Interdisciplinary Study;International;Intervention;Knowledge;Leadership;Life Expectancy;longitudinal care;low and middle-income countries;Lung;Lung Diseases;Manuscripts;Measurement;Measures;meetings;Multicenter Studies;Multicenter Trials;National Heart, Lung, and Blood Institute;pandemic disease;Patients;Persons;Population;Prevention;Protocols documentation;Public Health;Quality Control;Questionnaires;Recording of previous events;Reporting;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;Research Support;Resource-limited setting;Resources;response;Rice;Running;service delivery;Service delivery model;Site;skill acquisition;Sleep;Sleep Disorders;Specific qualifier value;Structure;supply chain;System;Testing;Training;Training Programs;Universities;Washington;web site

PROJECT_TITLE: Implementation Research Strategies for Heart, Lung, and Blood Co-morbidities in People Living with HIV - Research Coordinating Center


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: SHRIVER, MAREY R. (contact)

PROJECT_TERMS: Academia;Address;African American;Alaska Native population;American Indians;Area;Baltimore;Biomedical Research;Black race;Cancer Biology;career;cohort;Collaborations;Communicable Diseases;County;COVID-19 pandemic;Development;Development Plans;Doctor of Philosophy;Educational Curriculum;Educational process of instructing;Engineering;Ensure;Equity;equity, diversity, and inclusion;Event;experience;Faculty;Goals;graduate school;Grant;Health;health disparity;health inequalities;Hispanic;Immunology;Individual;Inosine Diphosphate;Institution;Joints;junior high school;Knowledge;Latinx;Leadership;Maryland;medical schools;Medicine;member;Mentors;Microbiology;Minority;minority scientist;Mission;Modeling;Monitor;Motivation;Neurosciences;peer coaching;Population;Positioning Attribute;professor;programs;recruit;Research;Research Personnel;Research Project Grants;Resources;Scholars Program;Science;skill acquisition;skills;social;social integration;stem;Students;success;Teacher Professional Development;Technology;tenure track;Textiles;Training;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: University of Maryland First Program


PI_NAMEs: STECK, SUSAN E (contact)

PROJECT_TERMS: Address;Advocate;Appointment;Benchmarking;career;Career Mobility;Climate;cohort;Collaborations;college;Communication;Communities;data sharing;Development;Discipline of Nursing;Disparate;early-career faculty;Education;Educational Curriculum;Educational workshop;Ensure;equity, diversity, and inclusion;Evaluation;Event;Evidence based practice;experience;Extramural Activities;Faculty;faculty mentor;Focus Groups;Fostering;Funding;Funding Agency;Goals;Grant;health disparity;health equity;Health equity research;implicit bias;improved;Individual;innovation;Institution;interest;Investigation;Leadership;leadership development;Learning;Life;meetings;member;Mentors;Minority;Minority Groups;Monitor;multidisciplinary;Outcome;peer;peer coaching;Persons;Policies;posters;Process;Productivity;professor;Program Development;programs;Public Health Schools;recruit;Research;Research Personnel;Research Support;Resources;Scholarship;Science;senior faculty;skill acquisition;skills;South Carolina;success;support network;synergism;System;Teacher Professional Development;tenure track;Training;Training Activity;Translating;Universities;Work;working group;Writing

PROJECT_TITLE: Faculty Development Core


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: BROWN, JESSICA  (contact)

PROJECT_TERMS: Address;Area;Award;Baltimore;Biomedical Research;Cancer Biology;career;Climate;Communicable Diseases;Communities;County;elementary school;Engineering;Evaluation;Faculty;Faculty Recruitment;faculty support;Feedback;Fostering;Goals;graduate school;Grant;Immunology;improved;Individual;Institution;interest;Interview;Joints;Knowledge;Leadership;Learning;Maryland;medical schools;Medicine;member;Mentors;Methods;Microbiology;Minority Groups;Modeling;Modification;Monitor;Motivation;Neurosciences;Outcome;Policies;Positioning Attribute;primary outcome;Procedures;Process;Productivity;professor;programs;Publications;recruit;Scholars Program;Science;skill acquisition;social integration;Societies;Structure;Students;success;Surveys;Teacher Professional Development;Technology;Time;Training;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Work;Writing


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: WINSTON-SALEM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE The CALIBIR program takes advantage of the broad, interdisciplinary research in biomedical informatics and data science within the Center for Biomedical Informatics and the participating faculty laboratories at Wake Forest School of Medicine and Wake Forest University. CALIBIR will provide diverse cohorts of undergraduate and master’s level students, who are underrepresented in the biomedical and behavioral sciences, with an opportunity to participate in biomedical informatics and data science education and research training. The overarching goal of the CALIBIR program is to create a pipeline for well-trained underrepresented students to pursue graduate research and careers in the field of biomedical informatics and data science.

PI_NAMEs: GURCAN, METIN NAFI (contact);MOVAGHAR, AREZOO ;WEAVER, ASHLEY

PROJECT_TERMS: Address;Advisory Committees;Area;Artificial Intelligence;Awareness;Basic Science;Behavioral Sciences;Bioinformatics;Biology;Biomedical Engineering;biomedical informatics;career;Chemistry;Clinical;Clinical Data;Clinical Informatics;Clinical Research;clinically relevant;cohort;Collaborations;college;Communication;Competence;computer science;Data Science;data science education;Degree program;design;Development;Discipline;Doctor of Philosophy;Education;Educational Activities;Educational workshop;Engineering;Ensure;Environment;Ethics;Evaluation;Event;evidence base;experience;Faculty;faculty mentor;Fostering;Funding;Goals;Graduate Degree;graduate school;health disparity;Health system;Healthcare;imaging informatics;Immersion;improved;Individual;Influentials;Informatics;Infrastructure;innovation;Interdisciplinary Study;interest;Internships;Investigation;Journals;Laboratories;Learning;lectures;Mathematics;matriculation;Measurable;Medical;medical schools;Mentors;Monitor;Oral;Outcome;Participant;Patient Self-Report;Pattern;Physics;Positioning Attribute;Preparation;Program Evaluation;programs;Psychology;Publications;Radial;Recording of previous events;recruit;Research;research faculty;Research Project Grants;Research Training;responsible research conduct;Scientific Evaluation;skills;social;Sociology;statistics;Structure;Students;summer internship;summer research;Techniques;tool;Training;Training Activity;Training and Education;Training Programs;undergraduate student;Underrepresented Students;Universities;Vision;Writing

PROJECT_TITLE: Culturally Augmented Learning In Biomedical Informatics Research (CALIBIR) Program


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Clinical Research;Complementary and Integrative Health;Drug Abuse (NIDA only);Eye Disease and Disorders of Vision;Mental Health;Substance Misuse

PI_NAMEs: SIMON, MELISSA A. (contact)

PROJECT_TERMS: Acceleration;Accountability;Achievement;Administrator;Advisory Committees;Area;Behavior;Biomedical Research;Brain;Cardiovascular system;career;Cells;cohort;Collaborations;Communication;Communities;Development;diversity and inclusion;efficacy evaluation;Elements;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;experience;Faculty;Faculty Recruitment;faculty support;Fostering;Funding;Goals;Grant;improved;Infrastructure;innovation;Institution;Investments;Knowledge;Lead;Leadership;Malignant Neoplasms;Mentors;Mentorship;Mind;Mission;Neighborhoods;Office of Administrative Management;operation;Outcome;Personal Satisfaction;Policies;Procedures;Process;Productivity;programs;Qualifying;Records;recruit;Research;Resource Allocation;Resource Development;Resources;role model;Shapes;Sister;Strategic Planning;Structure;success;synergism;Teacher Professional Development;tenure track;Time;Underrepresented Populations;United States National Institutes of Health;Universities;Vision;Work


PI_NAMEs: BRYAN, MICHELLE  (contact)

PROJECT_TERMS: Accountability;Achievement;Agency for International Development;Belief;Benchmarking;Biomedical Research;Businesses;career;Career Mobility;Charge;cohort;Collaborations;Complex;Creativeness;Critical Race Theory;Data;Data Collection;Decision Making;Development;Education;Effectiveness;Elements;Ensure;Environment;Equity;Evaluation;experience;Faculty;faculty support;Feedback;flexibility;Goals;Grant;higher education;Human Resources;improved;Incubators;Individual;innovation;insight;Institution;intersectionality;Intervention;Knowledge;Leadership;Lesbian Gay Bisexual Transgender Queer Questioning;Measures;member;Mentors;Methods;Minority;Minority Groups;Modeling;Monitor;Organizational Policy;Outcome;people of color;Performance;Persons;Policies;Procedures;Process;Program Evaluation;programs;Questioning individuals;recruit;Reporting;Research;Science;social;South Carolina;Strategic Planning;Structure;success;System;Teacher Professional Development;Testing;theories;Time;Training;Universities;Woman;Work

PROJECT_TITLE: Evaluation Core


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Complementary and Integrative Health;Drug Abuse (NIDA only);Eye Disease and Disorders of Vision;Mental Health;Substance Misuse

PI_NAMEs: MCCOLLEY, SUSANNA A (contact)

PROJECT_TERMS: Acceleration;Award;Behavior;career;career development;Career Mobility;Cells;Climate;cohort;Communication;Communities;community building;Competence;Complement;Development;diversity and inclusion;Ecology;Ecosystem;empowerment;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;evidence base;Evidence based program;experience;Faculty;Faculty Recruitment;Fostering;Goals;Grant;Growth and Development function;holistic approach;improved;Infrastructure;innovation;Institution;Leadership;member;Mentors;Mentorship;microaggression;Neighborhoods;Pathway interactions;Play;Policies;Problem Solving;Process;Program Sustainability;programs;recruit;Research;resilience;Resources;scaffold;Schools;Science;Self Care;Senior Scientist;skills;social;Structure;success;Teacher Professional Development;tool;Training;Underrepresented Populations;Universities;Vocational Guidance;Writing


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: AHRQ Project summary Our Diagnostic Center of Excellence (DCE) will focus on detecting in real time patients with delayed diagnosis of cancer especially among marginalized patients, and then learning deeply from them about what went wrong, how delays could be avoided, and strategies to mitigate any harm that has occurred. This DCE will integrate extensive expertise on safety science, diagnosis improvement, and Communication and Resolution Programs (initiatives to detect and empathically respond to harm events). These insights from patients who have experienced delayed cancer diagnosis about what happened and how we can improve are at present largely missing but are essential if meaningful reductions in delayed diagnoses are to occur.

PI_NAMEs: GALLAGHER, THOMAS HENRY;SCHIFF, GORDON DAVID (contact)

PROGRAM_OFFICER_NAME: COSBY, KAREN

PROJECT_TITLE: ACHIEVING BETTER CANCER DIAGNOSIS (ABCD): Identifying, supporting, and learning from marginalized patients who experience delayed cancer diagnosis


NIH_SPENDING_CATS: Clinical Research;Pediatric;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The goal of this project is to increase students’ understanding and interest in science through active participation in the first large-scale surveillance initiative targeting avian viruses like influenza viruses (AIV) and avian paramyxoviruses (APMV, also known as Newcastle disease virus) conducted in an urban area - New York City, New York.

PI_NAMEs: KRAMMER, FLORIAN  (contact);MARIZZI, CHRISTINE

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Adult;after-school program;Avulavirus;Awareness;Bioinformatics;Birds;broadening participation research;Collaborations;Collection;Columbidae;Communication;Communities;community organizations;community science;Data;Data Analyses;Data Collection;data dissemination;design;Development;Disadvantaged;Drops;Education;Education and Outreach;Educational Curriculum;Educational process of instructing;Educational workshop;Ensure;Environment;Equipment;Event;Experimental Designs;Feces;Fostering;future pandemic;Genbank;Goals;Health;health literacy;high school;High School Student;Human;Individual;influenzavirus;Infrastructure;innovation;Institution;interest;Internet;Internships;junior high school;Knowledge;Laboratories;Learning;learning engagement;medical schools;member;Mentors;Mentorship;Methods;Middle School Student;Modernization;Molecular;Molecular Biology;New York;New York City;Newcastle disease virus;next generation;novel therapeutics;novel vaccines;nucleic acid detection;Nucleic Acids;Participant;peer;Peer Review;personalized approach;Phase;Phylogenetic Analysis;prevent;Process;programs;Protocols documentation;Publications;Race;recruit;Research;Research Design;Research Infrastructure;sample collection;Sampling;Schools;Science;Scientist;Sequence Analysis;service learning;Spanish/English;STEM career;Structure;Student recruitment;Students;symposium;System;teacher;Teacher Professional Development;Techniques;Training;Underrepresented Minority;Underrepresented Populations;Universities;university student;Update;urban area;Viral;virology;Virus;Work;Youth

PROJECT_TITLE: New York City Virus Hunters - A Community Science Initiative

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Cancer;Clinical Research;Complementary and Integrative Health;Drug Abuse (NIDA only);Eye Disease and Disorders of Vision;Mental Health;Substance Misuse

PI_NAMEs: HOLMES, KRISTI  (contact)

PROJECT_TERMS: Accountability;Area;Attitude;Behavior;Biomedical Research;career;cohort;Collaborations;Common Data Element;Communication;Communities;Complex;cultural values;Data;Data Collection;Data Sources;design;Ecosystem;efficacy evaluation;Elements;empowerment;Ensure;Equity;equity, diversity, and inclusion;Evaluation;Evidence based practice;Faculty;faculty community;Failure;Feedback;Focus Groups;formative assessment;Fostering;Goals;implementation determinants;improved;Individual;Infrastructure;Institution;interoperability;Intervention;Interview;Knowledge;knowledge translation;Leadership;Maps;Measures;member;Mentors;Methods;Modeling;Monitor;operation;organizational climate;Outcome;Participant;Pathway Analysis;Perception;Policies;primary outcome;Process;Program Evaluation;programs;Progress Reports;recruit;Reporting;Reproducibility;Research;research faculty;Research Personnel;Schools;skills;Social Network;Source;Structure;success;Surveys;System;Teacher Professional Development;Testing;Time;timeline;United States National Institutes of Health;Universities;Work


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Stanford Vision Research Core NARRATIVE RELEVANCE  This Stanford University Vision Research Core Grant will provide services and resources in four areas critical to extending the reach of vision research among the NEI-funded Stanford investigators, to accelerating discoveries in these laboratories, to promoting inter-disciplinary collaboration that bridges molecular through systems level vision research, and to attracting new faculty at junior through senior levels into vision research.

PI_NAMEs: GOLDBERG, JEFFREY L (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Acceleration;Adult;Area;Cells;Communities;Core Grant;Data;Development;Device Designs;Device or Instrument Development;Discipline;Disease;Dryness;Faculty;Faculty Recruitment;Funding;Grant;Growth;Image;in vivo;innovation;Intention;interdisciplinary collaboration;Laboratories;medical specialties;Molecular;neurogenetics;Neurosciences;next generation;Ophthalmology;Outcome;Positioning Attribute;recruit;Research;Research Personnel;Resources;Seasons;Services;Structure;System;tool;Training;Universities;vector;Viral Vector;Vision;Vision research

PROJECT_TITLE: Stanford Vision Research Core


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Rehabilitation;Substance Misuse

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Humans can perform a range of static and dynamic grasping movements with a high level of skill, yet it is unclear how cortex achieves this flexibility in control. We will study how population dynamics in motor cortex change with behavioral context and how they are shaped by sensory feedback. Through this proposal, we will gain a better understanding of how motor cortical activity generalizes across static and dynamic behaviors as well as the potential to drive plasticity within cortical circuits that communicate sensorimotor information, which has relevance for understanding skill learning and improving rehabilitation after injury.

PI_NAMEs: COLLINGER, JENNIFER L. (contact)

PROGRAM_OFFICER_NAME: GEBREHIWET, HERMON RUSSOM

PROJECT_TERMS: Address;Afferent Pathways;Anatomy;Area;arm;arm movement;Automobile Driving;Behavior;Behavioral;brain computer interface;Cognitive;Communication;Complex;Consensus;Data;Dependence;Development;Dimensions;Electrodes;Esthesia;Exhibits;experimental study;Feedback;Fingers;flexibility;Freedom;Goals;grasp;Hand;Human;Implant;improved;Injury;Knowledge;Learning Skill;Location;Mediating;microstimulation;Motor;motor behavior;motor control;Motor Cortex;Movement;neural;neuroregulation;novel;Output;Participant;Pathway interactions;Peripheral;population based;Population Dynamics;Posture;Quadriplegia;Rehabilitation therapy;response;Role;Sensory;sensory feedback;sensory input;Shapes;Signal Transduction;skills;somatosensory;Somatosensory Cortex;Stable Populations;TACSTD2 gene;Tennis;Testing;Touch sensation;Training;transcutaneous stimulation;Uncertainty;Variant;Work

PROJECT_TITLE: Influence of Task Complexity and Sensory Feedback on Cortical Control of Grasp Force


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Eye Disease and Disorders of Vision;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: BACCUS, STEPHEN A (contact)

PROJECT_TERMS: Algorithms;analysis pipeline;Animals;Area;Artificial Intelligence;Big Data;Bioinformatics;Biological Process;Biometry;career networking;Cells;Clinical Trials Design;cloud based;Collaborations;Complex;Complex Analysis;Computer Analysis;Computer Models;Computer software;Computerized Medical Record;Computers;Computing Methodologies;computing resources;Data;Data Analyses;data exchange;data management;Data Science;Data Set;Databases;Dedications;design;Development;Disease;Elements;Environment;Epigenetic Process;experience;experimental study;Eye;Funding;Genome;high dimensionality;High Performance Computing;Human;Human Resources;human subject;Human Subject Research;Image;innovation;Institution;interest;Knowledge;Laboratories;laboratory experience;large datasets;Machine Learning;Magnetism;metabolomics;Modeling;Molecular;mRNA sequencing;Natural Language Processing;neural;Neurobiology;Neuroglia;Neurons;novel;novel strategies;Ophthalmology;Optics;Performance;Photoreceptors;Population;power analysis;Pre-Clinical Model;Process;prospective;Proteome;Proteomics;Registries;repository;Research;Research Personnel;Resources;Sampling;Scientist;senior faculty;Services;Signal Transduction;Software Design;Speed;Structure;System;Technology;terabyte;Time;Tissues;tool;transcriptome sequencing;Variant;virtual machine;Vision;vision development;Vision research;Visual;visual information;visual stimulus;Visual System;Work

PROJECT_TITLE: Advanced Computation Core


PI_NAMEs: MOORE, TIRIN  (contact)

PROJECT_TERMS: 3D Print;Advertising;behavior measurement;Behavioral Assay;Callithrix;Collaborations;Communication;Communities;Computer-Aided Design;cost;Custom;Data Collection;data sharing;design;design and construction;Development;Device Designs;Device or Instrument Development;Devices;Electrophysiology (science);Equipment;experience;experimental study;fabrication;Faculty;fly;Fostering;Funding;Goals;human model;Human Resources;Image;innovation;instrument;instrumentation;interest;Laboratories;Macaca mulatta;manufacture;Medicine;Mus;Neurobiology;novel;Preparation;prototype;Research;Research Personnel;Research Project Grants;Resources;Scientist;Services;Source;Speed;success;Techniques;Technology;Vision;Vision research;Visual Psychophysics

PROJECT_TITLE: Device Design and Development Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE Infantile rhabdomyosarcoma (RMS) is a newly identified and poorly understood aggressive pediatric muscle cancer that affects young children. There is one single mutation that causes the disease, but we do not have specialized treatments targeting this genetic event, and patients are treated with general strategies that are often ineffective or have harsh life-long side effects. We will leverage novel zebrafish and mouse cancer models to help young children with cancer by understanding the biology of how infantile RMS develops and implementing these models to identify clinically tractable therapeutic targets.

PI_NAMEs: KENDALL, GENEVIEVE CLAIRE (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Actins;Address;ADP-ribosylation factor 6;Affect;Allografting;Alveolar Rhabdomyosarcoma;Animal Model;Animals;Binding;Biochemical;Biology;Cancer Biology;Cancer Model;Cell Culture Techniques;Cell Line;Cell Lineage;Cells;chemotherapy;Child;Childhood;Chromatin;Classification;Clinical;clinical care;clinical sequencing;comparative;Complex;Data;Development;Developmental Biology;Developmental Gene;Disease;druggable target;Embryonal Rhabdomyosarcoma;Endocytic Vesicle;Event;FOXO1A gene;Gene Expression Profile;Gene Fusion;Genetic;Genetic Diseases;Genetic Transcription;Genomics;Goals;Human;human disease;infancy;innovation;Knock-out;Knowledge;Malignant Childhood Neoplasm;malignant muscle neoplasm;Malignant Neoplasms;Maps;Mediating;Modeling;Molecular;Monomeric GTP-Binding Proteins;Mus;Muscle;Muscle Development;mutant;Mutation;Myoblasts;myogenesis;NCOA2 gene;novel;novel therapeutic intervention;Nuclear Receptors;Oncogenes;Oncogenic;Oncology;Operative Surgical Procedures;overexpression;Pathway interactions;patient derived xenograft model;Patients;PAX3 gene;Predisposition;progenitor;programs;Property;Radiation;Research;Rhabdomyosarcoma;Role;Sampling;Series;side effect;Skeletal Muscle;small molecule;spatiotemporal;Structure;System;targeted treatment;Tertiary Protein Structure;Testing;Therapeutic;therapeutic target;Transcription Coactivator;transcription factor;Transgenic Organisms;tumor;tumor initiation;tumorigenesis;tumorigenic;Validation;Zebrafish;zebrafish development

PROJECT_TITLE: Understanding Infantile Rhabdomyosarcoma Biology and Therapeutic Targets

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Genetics;Neurosciences

PI_NAMEs: HU, YANG  (contact)

PROJECT_TERMS: adaptive optics;Behavior;Brain;Candidate Disease Gene;Capsid;chemical genetics;Collaborations;Confocal Microscopy;cost;Custom;design;Development;Discipline;Disease;Experimental Genetics;Failure;Feedback;fluorescence microscope;Genes;Genetic;genetic technology;Goals;Health;Image;imaging approach;imaging modality;imaging system;Imaging technology;improved;in vivo;in vivo fluorescence;in vivo imaging;Individual;innovation;Label;Laboratories;Microscopy;model organism;Monitor;multiphoton microscopy;neurogenetics;Neuroglia;Neurons;novel strategies;Ophthalmology;Ophthalmoscopes;Optical Coherence Tomography;optical imaging;pharmacologic;prevent;Production;promoter;Reagent;Records;Research;Research Personnel;Resources;Retina;Scientist;Serotyping;skills;Specificity;success;Technology;Testing;Time;tool;Training;Viral;Viral Vector;Virus;virus genetics;Vision;Vision research;Visual;visual neuroscience;Visual System

PROJECT_TITLE: Neurogenetics of Vision Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: DUBRA, ALFREDO  (contact)

PROJECT_TERMS: Acceleration;adaptive optics;Adoption;analysis pipeline;Antibodies;Behavioral;Charge;Collaborations;Communities;Computer software;Confocal Microscopy;cost;Creativeness;Custom;Data;data acquisition;Data Analyses;data exchange;Data Set;data sharing;data tools;Dedications;Development;Device or Instrument Development;Discipline;Disease;Documentation;Educational workshop;Electronics;experimental study;Faculty;fluorescence microscope;Goals;Grant;Health;high risk;Hour;Human Resources;Image;imaging approach;imaging modality;imaging system;Imaging technology;In Vitro;in vivo;in vivo fluorescence;in vivo imaging;innovation;instrument;Investments;Label;Laboratories;Lasers;Light;member;Microscope;microscopic imaging;Microscopy;Modality;Modification;Monitor;multiphoton microscopy;neural;neurogenetics;Neurons;novel;novel strategies;Ophthalmology;Ophthalmoscopes;Ophthalmoscopy;Optical Coherence Tomography;optical imaging;Optics;optogenetics;Output;Photic Stimulation;Play;process optimization;Protocols documentation;Reagent;recruit;Renaissance;Research;Research Personnel;Role;Scanning;Scientist;sensor;service programs;Services;Slide;software development;Stimulus;Structure;superresolution microscopy;synergism;System;Technology;Technology Transfer;Testing;Time;tool;Training;two photon microscopy;two-photon;virtual reality environment;Vision;Vision research;vision science;Visual;visual stimulus;Visual System;Work

PROJECT_TITLE: Imaging Structure and Function Core


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Eye Disease and Disorders of Vision;Neurosciences;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative: Nearly 300 million individuals have diabetes worldwide and approximately 35% of diabetic patients will have some form of diabetic retinopathy (DR) with 5 to 10% of these individuals experiencing permanent vision loss. DR progresses in many patients despite preventable measures such as lowering of high blood pressure and strict control of blood glucose – DR remains the leading cause of legal blindness among working-age adults. A growing body of scientific evidence indicates that inflammation plays a prominent role in the progression of DR; therefore anti-inflammatory based therapies may slow progression of DR if applied early in its disease course.

PI_NAMEs: KIM, STEPHEN JAE (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Adrenal Cortex Hormones;Adult;Age;Anti-Inflammatory Agents;Antiinflammatory Effect;aqueous;Background Diabetic Retinopathy;Bilateral;Biochemical;Biological Markers;Blindness;Blood capillaries;Blood Glucose;blood glucose regulation;blood pressure control;Blood Vessels;Cataract;celecoxib;Chronic;Clinical;Cornea;Correlation Studies;cytokine;Development;Diabetes Mellitus;diabetic;diabetic patient;Diabetic Retinopathy;Diagnostic tests;Dinoprostone;Disability prevention;Disease;Disease Progression;disorder risk;Early identification;Early treatment;Endothelial Cells;experience;Extravasation;Eye;Formulation;Functional disorder;Fundus photography;Future;Glaucoma;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;Hypertension;Incidence;Individual;Inflammation;Inflammation Mediators;Inflammatory;Injections;innovation;Interleukin-6;Interleukin-8;Ketorolac;Legal Blindness;legally blind;Leukocytes;Long-Term Effects;macula;macular edema;Measures;Mediating;Mediator;Methods;Natural History;new therapeutic target;Non-Steroidal Anti-Inflammatory Agents;novel;novel marker;Optical Coherence Tomography;Oral;participant enrollment;Pathogenicity;Pathology;patient stratification;Patients;Penetration;Permeability;pharmacologic;Placebos;Play;prevent;Principal Investigator;prognostic;Randomized;Research;Retina;Retinal Diseases;retinal ischemia;Risk;risk prediction;risk stratification;Role;Sampling;screening;Self Administration;Serum;Severities;System;Testing;Therapeutic;Therapeutic Effect;Thick;Time;Topical application;treatment response;Vascular Endothelial Growth Factors;Vascular Permeabilities;Visual impairment;Vitreous humor;Work

PROJECT_TITLE: Ocular Inflammatory Mediators in the Pathophysiology of Diabetic Retinopathy

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Hematology;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PROJECT NARRATIVE Pancreatic cancer is the third leading cause of cancer deaths in the U.S., with approximately 60,430 new cases anticipated in 2021, resulting in a projected $3.2 billion burden to the healthcare system. The disease poses significant healthcare, economic, and societal challenges. The proposed research will test a promising new idea of targeting the blood clotting system to improve drug delivery and efficacy for treating pancreatic cancer.

PI_NAMEs: FISHEL, MELISSA L.;FLICK, MATTHEW J.;HAN, BUMSOO  (contact)

PROGRAM_OFFICER_NAME: UJHAZY, PETER

PROJECT_TERMS: Ablation;Animal Model;Biomimetics;Blood coagulation;Blood specimen;Cancer Cell Growth;Cancer Etiology;CD8-Positive T-Lymphocytes;Cessation of life;Chemoresistance;Clinical;clinically relevant;Coagulation Process;Collagen;Data;Deposition;Desmoplastic;Disease;Drug Delivery Systems;drug efficacy;Drug resistance;Economics;efficacy validation;Evaluation;Extracellular Matrix;Extracellular Matrix Proteins;FDA approved;Feedback;Fibrin;Fibrinogen;Fibroblasts;Fibrosis;Goals;Growth;Healthcare;Healthcare Systems;Hyaluronan;Immune;improved;in vivo;inhibitor;Invaded;Knowledge;Lead;Libraries;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Molecular;Molecular Target;novel strategies;Outcome;Outcomes Research;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;PAR-1 Receptor;Patients;Peptide Hydrolases;Pharmaceutical Preparations;pharmacologic;programs;Reagent;recruit;Reporting;Research;Resistance;Role;Signal Pathway;Signal Transduction;standard of care;Survival Rate;Syndrome;System;T-Lymphocyte;Testing;Therapeutic;therapeutically effective;therapy resistant;Thrombin;Tissue Model;Translating;translational potential;Translational Research;Treatment outcome;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumor-immune system interactions;vascular inflammation;venous thromboembolism

PROJECT_TITLE: Reprogramming PDAC Stroma by Targeting Coagulation in the Tumor Microenvironment


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Radiation Oncology

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Narrative With the strong clinical evidence provided by recent prospective clinical trials on the effectiveness of stereotactic radiosurgery for patients with multiple (≥ 4) brain metastases, national comprehensive cancer network guidelines no longer restrict the number of brain metastases for stereotactic radiosurgery. However, the large number of brain metastases with variable sizes and locations substantially increases the complexity of treatment planning, resulting in suboptimal plans, large quality variations, low planning efficiency, and subsequently deteriorated clinical outcome. We propose an artificial intelligence driven automatic treatment planning system for stereotactic radiosurgery of multiple brain metastases, aiming to consistently provide patient- specific high-quality treatment plans with high efficiency.

PI_NAMEs: TIAN, ZHEN  (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: 3-Dimensional;Affect;Artificial Intelligence;Beds;Brain;Cancer Patient;cancer therapy;Caring;Clinical;Clinical Research;Clinical Trials;Cognition;Communication;Computer Vision Systems;Consultations;Decision Making;deep learning;deep neural network;deep reinforcement learning;design;Deterioration;Development;Devices;Disease;Dose;Effectiveness;Evaluation;Excision;Feedback;Foundations;Gamma Knife Radiosurgery;Guidelines;Hour;Human;improved;individual patient;innovation;Intelligence;Knowledge;Learning;Life;Location;Malignant Neoplasms;Manuals;Mathematics;Medical Device;Medicine;Metastatic malignant neoplasm to brain;Methods;Modernization;National Comprehensive Cancer Network;Neurocognition;Neurocognitive Deficit;Normal tissue morphology;Operative Surgical Procedures;Organ;Outcome;palliative;Pancreas;Patient Care;patient prognosis;Patients;Physicians;Policies;preference;Process;prospective;Prospective Studies;Prostate;prototype;Psychological reinforcement;Radiation therapy;Radiosurgery;Reporting;Resource-limited setting;Rewards;Robotics;Safety;satisfaction;skills;standard of care;System;Systems Integration;Technology;technology development;Testing;Time;Treatment outcome;treatment planning;tumor;Validation;Variant

PROJECT_TITLE: Artificial Intelligence Driven Automatic Treatment Planning of Stereotactic Radiosurgery for the Management of Multiple Brain Metastases

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

ORG_CITY: SAN DIEGO

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: OVERALL – Project Narrative San Diego State University (SDSU) is proposing a new faculty recruitment and retention program called SDSU FUERTE (Faculty Unified towards Excellence in Research and Transformational Engagement). Utilizing innovative, evidence-based strategies to promote institutional inclusive excellence, SDSU will recruit nine early-stage, interdisciplinary, tenure-track researchers who have career goals to address Latinx health disparities in the areas of Addiction Science, Environment Health, and Obesity/Physical Activity/Nutrition.

PI_NAMEs: REED, MARK BRIAN;ZUNIGA DE NUNCIO, MARIA LUISA (contact)

PROJECT_TERMS: Academy;Acceleration;addiction;Address;Affect;Area;Biomedical Research;career;career development;Climate;cohort;Communities;community building;community engaged research;community engagement;design;Development;Development Plans;Discrimination;Disparity;Diverse Workforce;early-career faculty;Educational Curriculum;Eligibility Determination;Environment;Environmental Health;equity, diversity, and inclusion;Evaluation;evidence base;experience;Faculty;Faculty Recruitment;Funding;Goals;Grant;Growth;Health;health disparity;health science research;Health Sciences;Hispanic-serving Institution;Human;implementation science;improved;Individual;innovation;Institution;Institutionalization;interest;Knowledge;Latinx;Leadership;Mentors;Minority;Minority Groups;model development;Modeling;nutrition;Obesity;Peer Review;Personal Satisfaction;Persons;Physical activity;Positioning Attribute;programs;recruit;Research;Research Personnel;Resources;Scholarship;Schools;Science;Scientific Advances and Accomplishments;Secondary Schools;Secure;skills;Students;success;Teacher Professional Development;tenure track;Training;Underrepresented Minority;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: SDSU FUERTE: Faculty United towards Excellence in Research and Transformational Engagement


PI_NAMEs: REED, MARK BRIAN (contact)

PROJECT_TERMS: Acceleration;Accountability;addiction;Affect;American;Area;Biomedical Research;Charge;Climate;cohort;Collaborations;Color;Communication;Communities;community engagement;COVID-19 pandemic;COVID-19 vaccine;Development;Development Plans;Discrimination;Disparity;Doctor of Philosophy;Economics;Educational Curriculum;Educational Status;Ensure;Environmental Health;Equity;equity, diversity, and inclusion;ethnic diversity;Evaluation;evidence base;experience;Faculty;Faculty Recruitment;falls;Funding;gender diversity;Goals;Health;health disparity;Health Personnel;health science research;Health Sciences;higher education;Hispanic-serving Institution;Human;improved outcome;innovation;Institution;Institutionalization;interest;Knowledge;Latinx;Leadership;maltreatment;Medical;medical schools;Mentors;model development;Morbidity - disease rate;mortality;nutrition;Obesity;Operations Research;organizational climate;Outcomes Research;Persons;Physical activity;Population;Positioning Attribute;Principal Investigator;Process;Productivity;professor;programs;Public Health;racial diversity;Recording of previous events;recruit;Research;Research Personnel;Science;Scientific Advances and Accomplishments;skills;Social Work;STEM field;Structure;Students;success;synergism;Teacher Professional Development;tenure track;undergraduate student;Underrepresented Minority;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: SDSU FUERTE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-Y]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: TEMPE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative We hypothesize that circulating antibodies can be measured as specific biomarkers of lung and ovarian cancers. We will use state of the art immune profiling to discover, and validate, select protein and immune biomarkers for lung and ovarian cancer.

PI_NAMEs: ANDERSON, KAREN SUE;LABAER, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Academic Medical Centers;Address;Adoption;Antibodies;antimicrobial;ART protein;assay development;Autoantibodies;Autoantigens;B-Lymphocyte Epitopes;B-Lymphocytes;base;Benign;Binding;Biological Assay;Biological Markers;biomarker discovery;biomarker panel;biomarker signature;Blinded;Blood Tests;Boston;Breast;cancer biomarkers;Cancer Center;Cancer Control;Cancer Detection;cancer diagnosis;Cancer Patient;Cancer Vaccines;candidate marker;Carcinogenesis Mechanism;circulating biomarkers;CLIA certified;Clinical;clinical application;clinical assay development;clinical diagnosis;clinical diagnostics;clinical implementation;Collaborations;Collection;Complement;COVID-19 vaccine;Data;density;design;Development;Diagnostic;diagnostic platform;Disease;disease heterogeneity;Early Detection Research Network;Early Diagnosis;Environment;Enzyme-Linked Immunosorbent Assay;Epitopes;experience;Funding;Future;Genes;German population;Glycoproteins;glycosylation;glycosyltransferase;Goals;Heterogeneity;Human;Human Papillomavirus;Image;Immune;Immune response;Immune Sera;Immunity;Immunoassay;immunogenic;immunogenicity;Immunoglobulin G;Immunologic Markers;Immunology;improved;improved outcome;Individual;innovation;instrument;Laboratories;Length;lung cancer screening;Lung nodule;Malignant - descriptor;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Methods;microbial;microorganism antigen;migration;Migration Assay;Monitor;Morbidity - disease rate;mortality;multiplex assay;Mutation;NCI Center for Cancer Research;Nodule;novel;Nucleic Acids;operation;Ovarian;Persons;Phase;Phase III Clinical Trials;Plasmids;polypeptide;Polysaccharides;Post-Translational Protein Processing;Predictive Value;prevent;Production;Protein Array;protein biomarkers;protein expression;Protein Glycosylation;protein structure;Proteins;Proteome;Proteomics;rapid detection;rapid technique;repository;Reproducibility;respiratory pathogen;Sampling;screening;Screening for cancer;Screening for Ovarian Cancer;serological marker;Serology;Serology test;Serum;skills;specific biomarkers;Specificity;Speed;structural glycoprotein;Structural Protein;Structure;Symptoms;System;Technology;technology development;tumor;Tumor Antigens;Universities;Vaccine Design;Validation;validation studies

PROJECT_TITLE: High-throughput immunoproteomics for cancer biomarker discovery


NIH_SPENDING_CATS: Biotechnology;Cancer;Prevention

PI_NAMEs: LABAER, JOSHUA  (contact)

PROJECT_TERMS: Adherence;Agreement;Arizona;Basic Science;Biocompatible Materials;Biological Markers;biomarker discovery;biomarker validation;Boston;cancer biomarkers;Clinical;Clinical Sciences;Collaborations;Communication;Communities;community engagement;data sharing;design;Diagnostic;Early Detection Research Network;Ensure;Evaluation;Goals;Infrastructure;Institutional Review Boards;Intellectual Property;Laboratories;Leadership;Maintenance;material transfer agreement;meetings;Occupational activity of managing finances;operation;organizational structure;Reporting;Research;Research Activity;Research Personnel;Resource Sharing;Resources;Schedule;Site;success;Translational Research;Universities


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Lung;Lung Cancer;Ovarian Cancer;Precision Medicine;Prevention;Rare Diseases;Women's Health Research

PI_NAMEs: ANDERSON, KAREN SUE (contact)

PROJECT_TERMS: Academic Medical Centers;Antibodies;Antigens;antimicrobial;Attention;Autoantibodies;Bacterial Antigens;Benign;Biochemical;Biological Assay;Biological Markers;biomarker development;biomarker discovery;biomarker signature;biomarker validation;Biopsy;Blinded;Blood Tests;Boston;Breast;CA-125 Antigen;cancer biomarkers;cancer cell;Cancer Center;Cancer Detection;Cancer Patient;candidate marker;Categories;Cells;chest computed tomography;circulating biomarkers;CLIA certified;Clinical;cohort;Collaborations;Collection;Complement;Custom;density;Detection;Development;Diagnosis;Diagnostic;diagnostic assay;Discrimination;Disease;Early Detection Research Network;Engineering;Ensure;Enzyme-Linked Immunosorbent Assay;Exclusion;experience;Fungal Antigens;Genes;German population;Glycoproteins;Goals;Human;Human Genome;imaging modality;Immune;Immune response;immunogenic;Immunologist;immunoregulation;improved;Individual;Infection;infection rate;innovation;Laboratories;Length;Lung;Lung Diseases;Lung nodule;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Mammography;Measures;Methods;Microbe;microbial;microorganism;Morbidity - disease rate;mortality;Multicenter Studies;NCI Center for Cancer Research;novel;Nucleic Acids;Pathogenesis;Performance;Phase;Plasmids;Play;Population;Predictive Value;Protein Array;Protein Array Analysis;protein biomarkers;Protein Glycosylation;Protein Microchips;Proteins;Proteome;Proteomics;Reporting;repository;response;Role;Sampling;screening;Screening for cancer;Screening for Ovarian Cancer;Screening Result;Serology;Serum Proteins;success;System;Target Populations;Technology;Testing;Time;Transvaginal Ultrasound;Ultrasonography;Universities;Unnecessary Surgery;Validation;validation studies;Viral Antigens;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Biomarker Developmental Laboratory


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Comparative Effectiveness Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Precision Medicine;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE The most effective ways to personalize the prevention and treatment of prostate cancer using data from an individual patient are unknown. Our team of investigators applies a unique inter-disciplinary approach that combines available data with modern statistical techniques to understand long-term effects of prostate cancer interventions. In this application, we will evaluate personalizing patient care, including screening high-risk men more frequently, using biomarkers and imaging tests to select patients for biopsy, using patient and cancer features to determine when and which kinds of treatment to offer, and practical approaches for reducing racial disparities. This work will advance the evidence necessary to make informed decisions about individualized screening and treatment for this most common cancer in men.

PI_NAMEs: ETZIONI, RUTH D (contact);PASHAYAN, NORA ;RIZOPOULOS, DIMITRIS ;TSODIKOV, ALEXANDER

PROGRAM_OFFICER_NAME: ZHU, LI

PROJECT_TERMS: Address;Adherence;advanced disease;Area;Bahamas;Behavior;Biological Markers;Biopsy;black men;British Columbia;Calibration;Cancer Control;cancer diagnosis;Cancer Etiology;Cancer Intervention;Cancer Intervention and Surveillance Modeling Network;Cessation of life;Clinical;Clinical Sciences;Clinical Trials;college;cost;Country;curative treatments;Data;Data Set;Data Sources;Decision Making;Development;Diagnosis;Diagnostic;Disease;disease model;disease natural history;disorder risk;Early Diagnosis;early screening;Event;evidence base;Fred Hutchinson Cancer Research Center;Frustration;Funding Opportunities;genetic testing;high risk men;high risk population;Hormonal;Image;Imaging Device;Imaging technology;improved;Incidence;Individual;individual patient;individualized prevention;innovation;interdisciplinary approach;International;Intervention;Lead;Leadership;Learning;London;Long-Term Effects;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;men;Methodology;Michigan;Modeling;models and simulation;Modernization;mortality;Natural History;Neoplasm Metastasis;novel;novel marker;Outcome;overtreatment;Patient Care;Patient Selection;Patients;personalized care;personalized intervention;personalized medicine;personalized screening;Police;Policies;Population;Population Sciences;Positioning Attribute;Precision therapeutics;Process;process optimization;Prostate;prostate biopsy;prostate cancer model;Prostate Cancer therapy;PSA screening;racial disparity;Radical Prostatectomy;randomized trial;Recording of previous events;Recurrence;Reduce health disparities;Research Personnel;Resources;Risk;Risk Estimate;risk stratification;Route;Salvage Therapy;Saudi Arabia;screening;Screening for Prostate Cancer;screening policy;Solid;Solid Neoplasm;Source;Statistical Methods;Stratification;Techniques;Technology;Testing;Therapeutic;Time;treatment strategy;trend;United Kingdom;United States;Universities;Urologic Oncology;Validation;Work;working group

PROJECT_TITLE: Modeling Precision Interventions for Prostate Cancer Control


ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

PHR: Project Narrative - Overall X-ray crystallography, solution scattering and X-ray footprinting are critical tools in the study of biological systems. They provide information that has been a prerequisite to understanding the fundamentals of life. They are also methods that have proved themselves to be central to the development of new therapeutics for human disease. The overarching goal of this proposal is to provide an integrated synchrotron Resource that makes mature technologies available to a broad research community. This will lead to more insightful biological interpretation and better drugs to improve human health.

PI_NAMEs: ADAMS, PAUL DAVID (contact);HURA, GREGORY L

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: 2019-nCoV;Automation;beamline;Biocompatible Materials;Biological;biological systems;California;Collection;Communities;Complex;Country;Coupling;Cryoelectron Microscopy;Crystallization;Crystallography;Data;Data Analyses;Data Collection;data quality;Data Set;design;Development;Disease;Education and Outreach;Educational workshop;Effectiveness;Ensure;Exclusion;experience;experimental study;flexibility;Fluorescence Spectroscopy;Goals;Health;Human;human disease;improved;In Situ;Individual;Infrastructure;instrument;Internet;Investigation;Journals;Life;Ligands;Light;macromolecular assembly;Mass Spectrum Analysis;meetings;member;Methods;novel therapeutics;Office of Administrative Management;operation;outreach;pathogen;Peer Review;Performance;Pharmaceutical Preparations;Productivity;programs;Proteome;Publications;Raman Spectrum Analysis;recruit;Research;Research Personnel;Resources;response;Roentgen Rays;Route;screening;Site;small molecule;Source;structural biology;Structure;success;Synchrotrons;Techniques;Technology;Temperature;Testing;tool;Training;Work;X-Ray Crystallography

PROJECT_TITLE: ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)


NIH_SPENDING_CATS: Biotechnology;Cancer;Lung;Lung Cancer;Ovarian Cancer;Precision Medicine;Prevention;Rare Diseases;Women's Health Research

PI_NAMEs: STENGELIN, MARTIN  (contact)

PROJECT_TERMS: Antibodies;Antibody Affinity;antigen detection;Antigens;antimicrobial;Arizona;assay development;Autoantibodies;Autoantigens;B-Lymphocytes;base;Benign;Binding;Biological Assay;Biological Markers;biomarker development;biomarker discovery;biomarker identification;biomarker validation;Blinded;Breast;cancer biomarkers;cancer type;circulating biomarkers;Circulation;Clinical;cohort;Collaborations;comparative;Complement;Complex;Confidential Information;COVID-19 vaccine;Detection;detection assay;Development;Diagnostic;Diagnostic Procedure;Discrimination;Disease;Early Detection Research Network;Evaluation;extracellular vesicles;Funding;Future;Glycoproteins;glycosylation;Goals;good laboratory practice;Government;Immune;Immunoassay;immunogenicity;improved;industry partner;instrument;Laboratories;laboratory development;laboratory experiment;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;manufacture;Mass in breast;member;microbial;microorganism antigen;migration;Monoclonal Antibodies;multiplex assay;novel;novel marker;nucleic acid detection;Nucleic Acids;operation;Performance;Persons;Phase III Clinical Trials;Plasma;plasmid DNA;Printing;Procedures;Process;Production;Protein Array;protein biomarkers;Protein Glycosylation;protein purification;Proteins;radiological imaging;Reagent;Recombinant Proteins;Recombinants;Research;Resources;Sampling;scale up;screening;Screening for cancer;serological marker;Serology;Serology test;Signal Transduction;Specific qualifier value;Speed;Spottings;Testing;TP53 gene;Translations;tumor;tumorigenesis;Universities;Validation;validation studies

PROJECT_TITLE: Biomarker Developmental Unit


ORG_DEPT: PEDIATRICS

PHR: Project Narrative Newborn resuscitation is a time-pressured activity requiring teams of healthcare professionals to carry out invasive procedures in a specific sequence of steps in order to reduce neonatal mortality and morbidity as well as the subsequent emotional and financial burden to families and society. This project will combine expertise in human factors science, design thinking, engineering, simulation and neonatal resuscitation to study the system of neonatal resuscitation, identify threats to neonatal survival and quality of life, and develop strategies and technologies to remediate these threats to our most vulnerable patients. This comprehensive study of the system of neonatal resuscitation is an ideal undertaking for an established patient safety learning laboratory and highly experienced and qualified team of investigators.

PI_NAMEs: HALAMEK, LOUIS PATRICK (contact)

PROGRAM_OFFICER_NAME: HAUGSTETTER, MONIKA

PROJECT_TITLE: Applying Human Factors Science, Design Thinking and Systems Engineering to Mitigate Threats to Neonates Undergoing Resuscitation and Stabilization

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: ZUNIGA DE NUNCIO, MARIA LUISA (contact)

PROJECT_TERMS: Academia;Academy;Acceleration;Achievement;addiction;Address;Area;Biomedical Research;career;career life balance;Climate;cohort;college;Communities;community building;community engaged research;Community Networks;community partners;Coupled;curriculum development;Dedications;Development Plans;Disparity;Diverse Workforce;Educational Curriculum;Ensure;Environment;Environmental Health;Equity;equity, diversity, and inclusion;ethnic minority;Event;evidence base;Faculty;faculty community;faculty mentor;faculty research;faculty support;Fostering;Funding;Geography;Goals;Grant;Growth;Health;health disparity;Health Sciences;Human;implementation science;improved;Individual;Institution;Intervention;Knowledge;Latinx;Leadership;Life;Longitudinal cohort;Manuscripts;Mediation;member;Mentors;Mentorship;Mexico;Mind;Minority Health Research;minority scientist;model development;Modeling;Nutritional Study;Obesity;peer;peer coaching;peer networks;Personal Satisfaction;Persons;Physical activity;Positioning Attribute;Privatization;Productivity;programs;racial minority;Recommendation;recruit;Reporting;Research;research and development;research faculty;Research Personnel;Research Training;Resource Development;Resources;retention rate;Role;satisfaction;Schools;Science;Seasons;Self Efficacy;senior faculty;Services;skill acquisition;skills;Spanish;Structure;success;Syndrome;Teacher Professional Development;Time;tool;Training;Training Programs;Underrepresented Minority;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: SDSU FUERTE: Faculty Development Core


PI_NAMEs: ADAMS, PAUL DAVID (contact)

PROJECT_TERMS: Adoption;Advisory Committees;beamline;Biological Sciences;Budgets;Center Core Grants;Collaborations;Communities;Computer software;Data;Data Collection;Data Set;Databases;Deposition;design;Development;Education and Outreach;Ensure;experimental study;Feedback;Funding;Future;Goals;improved;Individual;Leadership;Link;Maintenance;Measures;meetings;Monitor;online resource;operation;Productivity;programs;Progress Reports;Publications;Reporting;Research;Research Personnel;Resources;Roentgen Rays;Running;Sampling;structural biology;Structure;Technology;Time;timeline;Training;United States National Institutes of Health;web interface;web portal;web services;web site;Writing;X-Ray Crystallography

PROJECT_TITLE: Administration Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BCMB-P]


ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Proposal Narrative Selective and effective delivery of anticancer drugs to in situ tumor will improve treatment outcomes. Herein, we are proposing to test exosomes as carriers of anticancer drugs for cancer treatment. Our preclinical studies will aid in advancing exosome-based therapy for future clinical testing.

PI_NAMEs: RAMESH, RAJAGOPAL  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Adjuvant;Animal Model;anti-cancer;Antibodies;anticancer activity;Antineoplastic Agents;Area;Binding;Biological;Blood Circulation;Cancer Biology;cancer cell;Cancer Control;Cancer Patient;cancer therapy;Cells;Cessation of life;Circulation;Cisplatin;Clinical;contrast imaging;cytotoxicity;Data;delivery vehicle;Development;Disease;Distant;Dose Limiting;Doxorubicin;Drug Carriers;Drug Delivery Systems;Drug Kinetics;drug release kinetics;Drug resistance;effective therapy;efficacy evaluation;Endosomes;Exhibits;Exocytosis;exosome;Fibroblasts;Formulation;Future;Gene Delivery;Growth;Human;Image;imaging agent;Immune checkpoint inhibitor;Immune response;Immunology;improved;In Situ;In Vitro;in vivo;Incidence;innovation;iron oxide nanoparticle;Laboratories;Ligands;Lipids;Lung;lung cancer cell;Lung Neoplasms;Magnetic Resonance Imaging;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Membrane;Modeling;Molecular;molecular targeted therapies;Monitor;Mononuclear;mortality;multidisciplinary;Mus;nanoparticle;Neoplasm Metastasis;neoplastic cell;Normal Cell;novel therapeutics;Oncologist;Organoids;overexpression;particle;Pathologic;Pathology;Patients;Phagocytes;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacy (field);Pilot Projects;Polyethylene Glycols;Polysialic Acid;preclinical study;Property;Proteins;Recurrent disease;Reporting;research clinical testing;Role;Signal Transduction;Site;spheroids;statistics;Study models;superparamagnetism;Surface;Survival Rate;System;Testing;TFRC gene;Therapeutic;Toxic effect;Treatment Efficacy;Treatment outcome;treatment response;tumor;tumor growth;tumor xenograft;uptake;Vesicle

PROJECT_TITLE: Exosomes as carriers of cancer therapeutics

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


PI_NAMEs: NIX, JAY C. (contact)

PROJECT_TERMS: beamline;Biological;biomedical scientist;Chemicals;Collaborations;Communication;Communities;Computer software;Data Collection;Education and Outreach;Educational workshop;Emergency Situation;Ensure;experimental study;Funding;General Population;Goals;hazard;Hazardous Substances;Home;Hour;Individual;Inservice Training;Institution;Instruction;Internet;Journals;Laboratories;Manuals;meetings;member;National Institute of General Medical Sciences;operation;outreach;pandemic disease;Peer Review;posters;Procedures;Productivity;Publications;Publishing;recruit;Recruitment Activity;Research Personnel;Research Project Grants;Resources;Roentgen Rays;Safety;safety assessment;Sampling;Schedule;Scientist;Site;structural biology;Structure;symposium;Synchrotrons;System;Techniques;Technology;Time;Training;Triage;United States National Institutes of Health;Update;Visit;web site;Work

PROJECT_TITLE: User Training and Outreach


PI_NAMEs: ALLAIRE, MARC  (contact)

PROJECT_TERMS: Address;automated analysis;Automatic Data Processing;Automation;beamline;Biological;biological systems;California;Consultations;COVID-19;COVID-19 pandemic;Crystallization;Crystallography;Data;data access;Data Analyses;Data Collection;data exchange;Data Set;Development;drug discovery;Ensure;experience;experimental study;Feedback;fighting;follow-up;Home;Infrastructure;Institution;instrumentation;Intervention;Intuition;Manuals;Methods;Molecular;Molecular Biology;operation;Positioning Attribute;Process;Productivity;programs;Publications;Research Personnel;Resources;response;robotic system;Running;Sampling;San Francisco;Scientist;skills;Structural Biologist;structural biology;Structure;success;synergism;System;Technology;Time;tool;Triage;United States National Institutes of Health;Universities;user-friendly;Vision

PROJECT_TITLE: Rapid-Response Crystallography