NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Dementia;Kidney Disease;Neurodegenerative;Neurosciences;Women's Health Research

PHR: Project Narrative – MAE-WEST SCORE Project 1 With advancing age, women and men age differently; women suffering more from Alzheimer’s disease and related dementias, heart failure with preserved ejection fraction, chronic kidney disease, and frailty. Recent work suggests that small blood vessel-related aging driven by chronic low-grade inflammation may be responsible for these aging disparities for women. Project 1 in the Microvascular Aging and Eicosanoids – Women’s Evaluation of Systemic aging Tenacity (MAE-WEST) (“You are never too old to become younger!”) Specialized Center of Research Excellence (SCORE) on Sex Differences will study pro and anti-inflammatory responses and small vessel aging traits in aging women and men in two independent community-based cohorts, which will improve public health by understanding those most at risk for age-related conditions in the population.

PROJECT_TERMS: Acceleration;Acute;Age;age difference;age effect;age related;age-related disease;Aging;aging process;aging related;Alzheimer's disease related dementia;Anti-Inflammatory Agents;Atherosclerosis Risk in Communities;Biological Aging;Blood Vessels;Body System;Brain;Cardiology;Cardiovascular system;Centers of Research Excellence;Chronic;Chronic Disease;Chronic Kidney Failure;Chronology;Clinical;clinical development;cohort;Communities;Data;Development;Disease;Disease Outcome;disparities in women;effective intervention;EFRAC;Eicosanoids;Elderly;Endothelium;Epidemiologist;Etiology;Evaluation;Exhibits;experience;Exposure to;Female;follow-up;frailty;Framingham Heart Study;functional decline;Functional disorder;Geriatrics;Goals;Gonadal Steroid Hormones;healthy aging;Heart;Heart failure;heart function;Hormonal;Human;Impaired cognition;improved;Incidence;indexing;Individual;Inflammation;Inflammatory;Inflammatory Response;Infrastructure;Investigation;Kidney;Life Cycle Stages;Lipids;Longevity;male;Maps;Mass Spectrum Analysis;Measures;Mediating;Mediation;Mediator;men;Methods;microvascular aging;Microvascular Dysfunction;Morbidity - disease rate;mortality;Nature;Nephrology;Neurocognitive;offspring;older men;older women;Organ;Outcome;Participant;Patients;Pattern;Physical activity;Physical Function;Plasma;Population;population based;Population Sciences;Populations at Risk;Predisposition;preservation;Prognosis;Public Health;rate of aging;Renal function;Reporting;Request for Applications;Resources;response;Risk;Risk Factors;Role;Sampling;Sampling Studies;Scientific Advances and Accomplishments;Scientist;sex;Sex Differences;sexual dimorphism;small molecule;Specialized Center;Stress;stressor;Structure;System;Techniques;Time;trait;translational scientist;Variant;Vascular Diseases;vascular risk factor;Woman;women versus men;Work

PROJECT_TITLE: MAE-WEST SCORE Project 1 Population


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Kidney Disease;Neurodegenerative;Neurosciences;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: Project Narrative – MAE-WEST SCORE Project 2 With advancing age, women and men age differently; women suffering more from Alzheimer’s disease and related dementias, heart failure with preserved ejection fraction, chronic kidney disease, and frailty. Recent work suggests that small blood vessel-related aging driven by chronic low-grade inflammation may be responsible for these aging disparities for women. Project 2 in the Microvascular Aging and Eicosanoids – Women’s Evaluation of Systemic aging Tenacity (MAE-WEST) (“You are never too old to become younger!”) Specialized Center of Research Excellence (SCORE) on Sex Differences will study sex-specific pro and anti- inflammatory response with small vessel aging physiology in mean and women and the role of FDA approved treatments which will contribute to improved public health by providing new treatment strategies.

PI_NAMEs: BAIREY MERZ, CATHLEEN NOEL (contact)

PROJECT_TERMS: Address;Age;age difference;age effect;age related;age related changes;age-related disease;Aging;aging process;aging related;aging related disease;Albumins;Alzheimer's disease related dementia;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Anti-Inflammatory Agents;Biological Aging;Biology;Blood Vessels;Body System;Brain;burden of illness;cardiac magnetic resonance imaging;Cardiology;Cell Physiology;Centers of Research Excellence;Chronic;Chronic Kidney Failure;Chronology;Clinical;clinical development;clinical phenotype;Clinical Sciences;Clinical Trials;Cognitive;Coronary;Data;Development;Diagnostic tests;Disease;Disease Outcome;Disease Progression;disparities in women;effective intervention;EFRAC;Eicosanoids;Elderly;Endothelial Cells;Endothelium;Enrollment;Epidemiologist;Evaluation;experience;FDA approved;Female;frailty;Functional disorder;functional status;Funding;Geriatrics;Goals;Gonadal Steroid Hormones;Heart;Heart failure;heart function;Human;Impairment;improved;Individual;Inflammation;Inflammatory;Inflammatory Response;Infrastructure;intervention effect;Intervention Trial;Investigation;Ischemia;Kidney;Libido;Life Cycle Stages;Longevity;male;Measures;Mediator;Medical;men;microvascular aging;Microvascular Dysfunction;Molecular;Morbidity - disease rate;National Institute on Aging;Nature;Nephrology;novel therapeutic intervention;Organ;Peripheral;Phenotype;Physiological;Physiology;Plasma;Play;Population Analysis;population based;preservation;prevent;prospective;Prospective Studies;Public Health;Randomized;rate of aging;Renal function;Request for Applications;Research;Resources;response;retinal imaging;Role;Sampling;Scientific Advances and Accomplishments;Scientist;Severities;sex;Sex Differences;sexual dimorphism;Specialized Center;Stress;stressor;Structure;System;systemic inflammatory response;targeted treatment;Testing;tonometry;trait;translational scientist;treatment as usual;Urine;Variant;Vascular Endothelium;Woman;women versus men;Work

PROJECT_TITLE: MAE-WEST SCORE Project 2 Clinical

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMNR-A]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Optimizing pre-exposure Prophylaxis (PrEP) access is crucial for ending the HIV epidemic, particularly among marginalized populations; though unhealthy alcohol use is a central modifiable risk factor for HIV incidence, few HIV prevention interventions exist that synergistically address both. Research is needed to understand PrEP uptake among individuals with unhealthy alcohol use and to develop scalable patient-centered interventions that synergistically address unhealthy alcohol use and HIV. The proposed sequential mixed methods study will use co-design methodology, guided by a Community Advisory Board, in nation’s largest provider of both HIV and alcohol-related care to examine PrEP initiation and persistence among patients with unhealthy alcohol use, including those from marginalized subgroups, and tailor and pilot a decision aid to foster shared decision- making to enhance uptake of PrEP concomitantly with provision of evidence-based alcohol-related care.

PI_NAMEs: EDELMAN, E. JENNIFER;WILLIAMS, EMILY CATERINA (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: addiction;Address;Adult;AIDS prevention;alcohol abuse therapy;Alcohol consumption;alcohol misuse;Alcohols;Algorithms;Attention;Behavior;Caring;cognitive interview;community advisory board;community engaged research;Consolidated Framework for Implementation Research;Continuity of Patient Care;Data;Decision Aid;Decision Making;design;Discover, Design, Build, and Test Framework;disorder prevention;Electronic Health Record;Eligibility Determination;Epidemic;Equity;ethnic identity;Ethnic Origin;evidence base;Evidence based intervention;experience;Foundations;Gender;Gender Identity;Geographic Locations;Health;Health Disparities Research;Hearing;HIV;implementation science;improved;Incidence;Individual;innovation;Intervention;Interview;Knowledge;marginalization;marginalized population;Medicine;Methodology;Methods;Minority;minority patient;Modeling;modifiable risk;National Institute on Alcohol Abuse and Alcoholism;Natural Language Processing;novel;Outpatients;patient oriented;patient subsets;Patients;Pattern;Persons;Pharmaceutical Preparations;pilot test;Population;pre-exposure prophylaxis;preference;prevent;preventive intervention;Primary Care;Primary Care Physician;primary care setting;Process;Provider;Race;racial minority;racial minority population;Recommendation;recruit;Research;Risk Factors;Safe Sex;Sampling;Sex Orientation;Sexual and Gender Minorities;sexual identity;sexual minority;sexual minority group;shared decision making;Stigmatization;Structure;Subgroup;targeted treatment;Testing;theories;traditional care;transgender;transmission process;treatment as prevention;United States;uptake;usability;Variant;Veterans;Veterans Health Administration;Viral;Visit;Work

PROJECT_TITLE: Informing and promoting Shared decision making for HIV Prevention and Alcohol Reduction: Engaging Diverse Veterans to Refine and Pilot a Decision Aid (SHARE Study)


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Prevention;Rehabilitation

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Individuals with Down syndrome (DS) have heterogeneous developmental outcomes and varying support needs which impact quality of life and contribute to significant family stress and financial burden. Identification of objective early markers, with robust neurobiological underpinnings, of specific cognitive, social, and sensory outcomes is key for advancing and tailoring early interventions for DS. This series of testable experiments described in this proposal will yield physiological biometrics of arousal that are objective, present in infancy, and provide clinically actionable targets for treatment in early life to ultimately lead to improved functional outcomes for those with DS.

PI_NAMEs: GRZADZINSKI, REBECCA LYNN (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Age Months;Amygdaloid structure;Arousal;autism spectrum disorder;Behavior;Behavioral;behavioral phenotyping;Biological Markers;Biometry;Brain;Brain imaging;Cardiac;career development;Caring;Characteristics;Clinical;clinically actionable;Cognitive;cognitive ability;cognitive skill;cohort;Collection;cost;Data;Data Analyses;Data Collection;Databases;Dedications;design;Development;Diagnostic;Dissection;Down's Syndrome;Early Intervention;Early treatment;Ensure;Environment;Etiology;experimental study;Family;Financial Hardship;Foundations;frontal lobe;functional improvement;functional outcomes;Genetic;genetic testing;habituation;imaging study;Impaired cognition;improved;Individual;infancy;Infant;interest;Intervention Studies;Investments;Knowledge;Learning;Life;Link;Literature;Measurement;Measures;Mentors;Mentorship;Methodology;multimodality;multisensory;Neurobiology;Neurodevelopmental Disorder;neuroimaging;novel;novel therapeutics;Occipital lobe;Outcome;parent project;Parents;Pathway interactions;Pattern;peer;Phenotype;phenotypic data;Physiological;Positioning Attribute;Pre-Clinical Model;pre-clinical research;Process;Quality of life;Reporting;Research;Research Personnel;Research Project Grants;Resources;respiratory;response;Sampling;Sensory;Series;Site;Sleep;social;Social Behavior;social skills;Stimulus;Stress;Supervision;Testing;Time;Training;United States National Institutes of Health;visual processing;visual tracking;Work

PROJECT_TITLE: Infant arousal as a predictor of functional outcomes in Down syndrome (DS)

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Neurodegenerative;Women's Health Research

PHR: Project Narrative – MAE-WEST SCORE Project 3 With advancing age, women and men age differently; women suffering more from Alzheimer’s disease and related dementias, heart failure with preserved ejection fraction, chronic kidney disease, and frailty. Recent work suggests that small blood vessel-related aging driven by chronic low-grade inflammation may be responsible for these aging disparities for women. Project 3 in the Microvascular Aging and Eicosanoids – Women’s Evaluation of Systemic aging Tenacity (MAE-WEST) (“You are never too old to become younger!”) Specialized Center of Research Excellence (SCORE) on Sex Differences will determine the if the pro and anti-inflammatory responses cause differences in cell and small vessel function in experimental models and human endothelial cells to improve public health by developing new treatment targets for age-related conditions.

PI_NAMEs: SHYY, JOHN YJ (contact)

PROJECT_TERMS: Acceleration;Accounting;Adult;Age;age difference;age effect;age related;age-related disease;Aging;aging process;aging related;aging related disease;Alzheimer's disease related dementia;Animals;antagonist;Anti-Inflammatory Agents;Aspirin;Basic Science;Binding;Bioinformatics;Biological Aging;biological sex;Biometry;Blood Vessels;Body System;Brain;brain endothelial cell;burden of illness;Cardiology;Cell Physiology;Cell surface;Cells;Centers of Research Excellence;Chronic;Chronic Kidney Failure;Chronology;Circulation;clinical development;Complex;CRISPR/Cas technology;Development;Disease;disease disparity;Disease Outcome;disparities in women;effective intervention;EFRAC;Eicosanoids;Elderly;Endothelial Cells;endothelial dysfunction;Enzymes;Epidemiologist;Epigenetic Process;Etiology;Evaluation;experience;Experimental Models;experimental study;exposed human population;Family;Female;forward genetics;frailty;Functional disorder;G-Protein-Coupled Receptors;Gene Expression;Genetic Transcription;Geriatrics;Goals;Gonadal Steroid Hormones;Health;Heart;Heart Diseases;Heart failure;heart function;Hormonal;Human;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Infrastructure;Intravenous infusion procedures;Kidney;Kidney Diseases;Laboratories;Life Cycle Stages;Link;Lipids;Longevity;male;Mediating;Mediator;men;microvascular aging;Microvascular Dysfunction;Morbidity - disease rate;Mus;Nature;Nephrology;Neurodegenerative Disorders;Non-Steroidal Anti-Inflammatory Agents;Nuclear Receptors;older adult;Organ;Pathway interactions;Phenotype;Polyunsaturated Fatty Acids;Predisposition;preservation;Prostaglandin-Endoperoxide Synthase;Public Health;rate of aging;receptor;Receptor Activation;Receptor Signaling;Regulation;Renal function;Request for Applications;Resources;response;RNA Interference;Role;Scientific Advances and Accomplishments;Scientist;senescence;Serum;sex;Sex Differences;sex disparity;sexual dimorphism;Signal Transduction;Specialized Center;stressor;Structure;System;systemic inflammatory response;therapeutic development;translational scientist;Variant;Vascular Endothelial Cell;Vasodilation;Woman;Work;young adult

PROJECT_TITLE: MAE-WEST SCORE Project 3 Animal


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Lung;Orphan Drug;Pulmonary Hypertension;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Pulmonary arterial hypertension (PAH) remains an incurable and often fatal disease characterized by irreversible vascular remodeling. Leveraging a well-powered cohort integrating the latest omics and computational methodologies is critically needed to identify candidate molecular drivers in PAH lungs as potential therapeutic targets. The proposed studies will utilize a combination of cutting-edge multiomic approaches and experimental biology to provide greater insight into a novel PAH-associated gene set derived from the largest PAH lung biobank to date, and will lay the groundwork for future mechanistic and translational studies.

PI_NAMEs: HONG, JASON  (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: biobank;Biology;Blood Vessels;Candidate Disease Gene;candidate identification;Cardiac Catheterization Procedures;career;cell type;Cells;cohort;Computer Analysis;Computing Methodologies;Critical Care;Data;Disease;effective therapy;Endothelium;Foundations;Future;Genes;Genetic Risk;Genetic Transcription;genome wide association study;Glycoproteins;Goals;Health;hemodynamics;Histologic;Human;In Situ;In Vitro;insight;Integrins;Investigation;knock-down;Knowledge;Lung;Malignant Neoplasms;Measures;medical schools;Mentors;Mesenchymal;Molecular;Molecular Profiling;multimodality;multiple omics;new therapeutic target;novel;Pathogenesis;Pathogenicity;Pathway Analysis;Pathway interactions;Patients;Phenotype;physician-scientist training program;Process;Prognosis;pulmonary arterial hypertension;Pulmonary arterial remodeling;pulmonary vascular cells;pulmonary vascular remodeling;Quality of life;Research;Resolution;Role;Sampling;Severities;single nucleus RNA-sequencing;skills;Small Interfering RNA;System;targeted treatment;Testing;therapeutic target;transcriptome sequencing;transcriptomics;translational study;Vascular remodeling;WNT Signaling Pathway

PROJECT_TITLE: Integrative Multiomics to Uncover Novel Genes and Networks in Pulmonary Arterial Hypertension

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: DALLAS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative We propose a cancer cell imaging program to probe the mechanisms of metastatic tumor formation in the context of the host environment. This critical step in the development of metastatic disease is likely to be accompanied by vulnerabilities of the cancer cells that could be exploited for clinical treatment. The proposed work will establish novel microscopy with unprecedented resolution while maintaining sufficient experimental throughput to discover the relevant metastasis-driving processes at the single cell level.

PI_NAMEs: DANUSER, GAUDENZ  (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;Acceleration;Adaptor Signaling Protein;Adopted;Affect;Algorithms;Architecture;Automobile Driving;Biological;Biological Assay;Biological Models;Blood Vessels;Cancer Biology;cancer cell;Cancer Etiology;Carcinoma in Situ;caveolin 1;cell behavior;Cells;Cellular biology;Cellular Morphology;Cessation of life;Chemicals;childhood sarcoma;Clinical Treatment;cloud based;Communities;Computer Vision Systems;Core Facility;Data;Development;dimensional analysis;Disease;Distant;Educational workshop;Embryo;Environment;Environmental Risk Factor;Event;Ewings sarcoma;experimental study;Extracellular Matrix;Extravasation;fluorescence imaging;functional adaptation;Goals;Heterogeneity;high dimensionality;high resolution imaging;high throughput screening;Human;Image;imaging approach;Imaging Device;imaging platform;imaging probe;imaging program;Immunofluorescence Immunologic;In Situ;Individual;Informatics;Institution;intravital imaging;Intrinsic factor;Invaded;Investigation;Label;Light;lipid metabolism;live cell imaging;lymphatic vessel;Malignant - descriptor;Malignant Bone Neoplasm;Malignant Neoplasms;Membrane;Membrane Proteins;Metabolic;Metabolism;Metastatic Melanoma;Methods;Microscope;Microscopy;Molecular;Molecular Analysis;molecular imaging;Molecular Probes;Morphology;multimodality;multiplexed imaging;Mus;nano;NCI Center for Cancer Research;Neoplasm Metastasis;novel;Oncogenic;Optics;Organ;Organism;outreach;Pattern;Periodicity;Physiological;Pilot Projects;Play;Primary Neoplasm;Process;programs;Proliferating;Property;quantitative imaging;Research;Research Personnel;Resolution;response;Role;Sampling;Series;Side;Signal Transduction;Site;Solid Neoplasm;Specimen;Speed;Subgroup;System;Technology;technology development;Testing;Thick;Tissue imaging;Tissues;Training;Tropism;tumor xenograft;Variant;WNT Signaling Pathway;Work;Xenograft procedure;Zebrafish

PROJECT_TITLE: Imaging mechanisms of metastatic tumor formation in situ


PROJECT_TERMS: 3-Dimensional;Administrative Coordination;anti-cancer research;Atlas of Cancer Mortality in the United States;Authorship;Bioinformatics;Budgets;Cancer Biology;cancer cell;cancer imaging;Cells;cellular imaging;Charge;Childhood Melanoma;childhood sarcoma;Collaborations;Communication;Communities;Computer software;Consensus;Core Facility;data sharing;Development;Development Plans;Educational workshop;Environment;experience;Fostering;Goals;Grant;hackathon;High Performance Computing;Home;Human Resources;Image;imaging platform;In Situ;Infrastructure;Inosine Dialdehyde;Institution;Investments;Leadership;Learning;Malignant Neoplasms;Medical center;meetings;Metabolic;Microscopy;Molecular;Morphology;Neoplasm Metastasis;Outcomes Research;outreach;Participant;Policies;Population;programs;Reagent;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resolution;Resource Sharing;Running;Science;Structure;Systems Biology;Technology;Testing;Tissues;Trainers Training;Work

PROJECT_TITLE: Administration and Coordination Core


PI_NAMEs: FIOLKA, RETO PAUL (contact)

PROJECT_TERMS: 3-Dimensional;adaptive optics;analysis pipeline;Anatomy;Animals;arm;Atlases;Automobile Driving;Behavior;Behavioral;Biological Assay;cancer cell;cell behavior;Cell Physiology;cell type;Cells;cellular imaging;Characteristics;Compensation;computational pipelines;Detection;Development;Disease;Disparate;Embryo;Endowment;Environmental Risk Factor;Evolution;fluorescence imaging;Fluorescence Microscopy;functional plasticity;Genomics;Heterogeneity;high resolution imaging;Human;Image;imaging capabilities;In Situ;Individual;Lasers;Light;Lighting;Machine Learning;Malignant Neoplasms;Maps;Metastatic/Recurrent;Microscope;Microscopy;model organism;Molecular;Molecular Probes;Monitor;Morphology;Multimodal Imaging;multimodality;Neoplasm Metastasis;next generation sequencing;non-genomic;novel;Optics;optogenetics;Organism;Pathway interactions;Pattern;Phase;Phenotype;Population;prevent;Process;programs;Proliferating;Property;Resolution;Signal Transduction;single cell sequencing;Site;software development;Source;Spottings;Stretching;submicron;System;Technology;technology development;Time;Tissues;transcriptomics;tumor;tumor xenograft;Variant;Visualization;Whole Organism;Xenograft Model;Xenograft procedure;Zebrafish

PROJECT_TITLE: Technical Development Unit 1: Intelligent live imaging of metastasis patterns and subcellular molecular states at the whole organism level


NIH_SPENDING_CATS: Bioengineering;Cancer;Networking and Information Technology R&D (NITRD)

PI_NAMEs: DEAN, KEVIN MICHAEL (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;automated analysis;Automation;Automobile Driving;Back;Biochemical;Biological;Biological Assay;Biosensor;cancer cell;cancer initiation;Cell Line;Cells;Cellular Morphology;Chemicals;Chemistry;Communities;Computer software;Computer Systems;Computer Vision Systems;Computing Methodologies;CRISPR/Cas technology;Cues;Data Analyses;design;Development;Dimensions;Dyes;Electromagnetics;Engineering;Event;Feedback;fluorescence imaging;Fostering;Frequencies;Goals;Heterogeneity;high resolution imaging;Image;imaging approach;imaging system;Immunofluorescence Immunologic;improved;In Situ;innovation;insight;instrument;Interleukin-2;Intrinsic factor;Label;Laboratories;Light;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measurement;Mechanics;Mediating;Metabolic;meter;Methods;Microscope;Microscopy;Microtomy;Molecular;Molecular Analysis;Morphology;multiplexed imaging;nano;Neoplasm Metastasis;next generation;Nodule;Nutrient availability;Optics;Organ;Organism;Oxidation-Reduction;Performance;Periodicity;Physics;Preparation;Process;programs;Proteins;Proteomics;Reagent;Refractive Indices;Resolution;Risk;Robotics;Sampling;Signal Transduction;Site;Slice;Solid Neoplasm;Solvents;Specimen;Speed;stressor;Technology;Testing;Thick;Thinness;Three-Dimensional Imaging;Tissue imaging;Tissue Preservation;Tissues;Transcript;Travel;usability;Validation

PROJECT_TITLE: Technical Development Unit 2: Intelligent Hyperspectral Imaging of Subcellular Molecular States at the Whole Organ Level


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Comparative Effectiveness Research;Health Services;Immunotherapy;Prevention;Tobacco;Tobacco Smoke and Health;Urologic Diseases

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Narrative We will complete the development, calibration and validation of two independent population models of bladder cancer, and will address major questions in the surveillance, treatment, prevention, and diagnosis of bladder cancer by means of comparative mathematical modeling.

PI_NAMEs: JALAL, HAWRE ;TRIKALINOS, THOMAS  (contact)

PROGRAM_OFFICER_NAME: TATALOVICH, ZARIA

PROJECT_TERMS: Address;advanced disease;Age;Antibody-drug conjugates;BCG Live;Biological Markers;biomarker driven;Bladder;bladder cancer prevention;Calibration;cancer care;Cancer Control;Cancer Detection;Cancer Etiology;Carcinogens;Cessation of life;chemical carcinogen;Chemical Exposure;chemotherapy;Chronic;chronic bladder irritation;cigarette smoking;Colorectal Cancer;comparative;comparative effectiveness;cost;cost effectiveness;cost estimate;Cystoscopy;Detection;Development;Diagnosis;Disease;Distal;Effectiveness;effectiveness evaluation;Environmental Exposure;gene therapy;Genitourinary system;Goals;Health Policy;high risk;Immune checkpoint inhibitor;Immunotherapy;improved;Incidence;Ingestion;insight;intravesical;Knowledge;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;mathematical model;Mathematics;men;Modality;Modeling;modifiable risk;Molecular Abnormality;Morbidity - disease rate;mortality;multimodality;muscle invasive bladder cancer;Natural History;Nature;Neoplasm Metastasis;non-muscle invasive bladder cancer;novel;novel marker;older men;Organ;Outcome;Patients;Persons;Policies;Population;predictive tools;preservation;prevent;Prevention;preventive intervention;Production;programs;Public Health;Recommendation;Recurrence;Research;Risk;Risk Factors;Schedule;screening;Screening for cancer;simulation;Smoking;smoking cessation;smoking exposure;Smoking History;smoking prevalence;Subgroup;Surgeon;surveillance strategy;Testing;Time trend;Tobacco use;Toxin;Treatment Effectiveness;trend;tumor;Uncertainty;Validation;Woman;Workplace

PROJECT_TITLE: Population Modeling of Bladder Cancer Detection and Control


ORG_CITY: CINCINNATI

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: NARRATIVE (Entire PPG) High-density lipoproteins (HDLs), sometimes called ‘good cholesterol,’ help protect against heart disease and diabetes and may help fight infection. The molecular processes that produce the various HDL subspecies is not well understood. These projects will combine human and animal studies with computer modeling and test tube studies to determine how HDL is made and how it may protect against heart disease.

PI_NAMEs: DAVIDSON, W SEAN (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Academic Medical Centers;Advisory Committees;Alabama;Animals;Apolipoprotein A-I;Apolipoprotein A-II;Apolipoproteins;Arteries;atherogenesis;ATP-Binding Cassette Transporters;Calibration;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cell surface;Chemicals;Cholesterol;Clinical;Clinical Research;Computational Biology;Computer Models;computer studies;Core Facility;cost effective;crosslink;Cryoelectron Microscopy;Development;Diabetes Mellitus;diabetic patient;Diagnostic;epidemiology study;Exhibits;Failure;fighting;Heart Diseases;Heterogeneity;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Homology Modeling;Human;In Vitro;Infection;interdisciplinary approach;ion mobility;Knowledge;Lipids;Lipoproteins;Macrophage;Measures;Mediating;Mediator;Membrane;Molecular;Molecular Conformation;molecular modeling;multidisciplinary;mutant;particle;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phospholipids;Plasma;Play;Principal Investigator;Process;Production;Program Research Project Grants;programs;Proteins;Proteome;Published Comment;Publishing;Recombinants;Research Personnel;Resources;Role;Sampling;Scaffolding Protein;Scientist;Site;Spectrometry;Structure;synergism;Testing;translocase;Tube;United States National Institutes of Health;Universities;Visit;Washington;Work

PROJECT_TITLE: Multi-disciplinary Approaches to HDL Structure, Assembly, and Functional Heterogeneity

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(MA)]


PROJECT_TERMS: Academic Medical Centers;Advisory Committees;Alabama;Biometry;cohort;Collaborations;Communication;Complex;Computational Biology;Data Storage and Retrieval;design;Direct Costs;Effectiveness;Ensure;experience;Funding;Goals;Grant;Heterogeneity;High Density Lipoproteins;Human;Individual;Institution;interdisciplinary approach;Laboratories;Lipoproteins;meetings;National Heart, Lung, and Blood Institute;operation;Pacific Northwest;Persons;Preparation;Principal Investigator;Production;Program Research Project Grants;programs;Progress Reports;Qualifying;Regulation;Reporting;Research;Research Personnel;Resolution;Resources;Site;South Carolina;Structure;success;symposium;synergism;System;Technology;United States National Institutes of Health;Universities;Update;Washington

PROJECT_TITLE: Administration Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Immunization;Infectious Diseases;Vaccine Related

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative This study aims to develop an understanding of the biology and functional implications of tissue resident memory T cells (TRM) in the mouth, a barrier mucosal site largely overlooked by T cell immunologists. T cells have recently been implicated in several oral disease and autoimmune states including periodontitis, canker sores, and oral lichen planus, yet currently an understanding of how T cells (in particular TRM) function in oral tissues is limited. Extending our knowledge of TRM biology into the oral mucosa will allow us to conceptualize TRM in oral health and disease and provide a foundation to develop therapeutic approaches that target oral TRM.

PI_NAMEs: STOLLEY, JAMES MICHAEL (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Acceleration;Address;Allergic Disease;Animal Model;Antibiotics;Antibodies;Antigens;antimicrobial;antiviral immunity;Aphthous Stomatitis;Architecture;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;Bacteria;Biology;Blood;career;career development;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Cellular biology;Chemicals;Choristoma;Chronic;Circulation;clinically relevant;Communicable Diseases;Dental Hygiene;dietary;Disease;Environment;Event;experimental study;Foundations;Gene Expression;Generations;Gingiva;Goals;Growth;Homeostasis;Human;Human Papillomavirus;Immune;Immune response;Immune System Diseases;Immunity;Immunologic Surveillance;Immunologics;Immunologist;Immunology;immunopathology;improved;Individual;Infection;Inflammation;Inflammatory;inhibitor;innovation;insight;Intercept;Invaded;Knockout Mice;Knowledge;Ligature;Location;Lung;Maintenance;malignant mouth neoplasm;Malignant Neoplasms;Mediating;Mediator;Memory;microbial;microbial community;Microscopy;migration;Molecular;mouse model;Mouth Diseases;mucosal site;Mucous Membrane;Mus;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Oral;Oral cavity;oral cavity epithelium;Oral health;oral infection;Oral Lichen Planus;oral microbiome;Oral mucous membrane structure;oral tissue;Organ;Parabiosis;pathogen;Pathogenesis;pathogenic bacteria;pathogenic fungus;pathogenic virus;Pathogenicity;Pathway interactions;Peptides;Periodontal Diseases;Periodontitis;Phase;Phenotype;Play;Population;Predisposition;prevent;Production;Property;Proteins;recruit;Regulation;Research Personnel;residence;Resources;Role;Saliva;Salivary Glands;secondary lymphoid organ;Severities;Shapes;Signal Transduction;Simplexvirus;Site;Skin;Solid;Specificity;T memory cell;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;tissue resident memory T cell;Tissues;Training;Transforming Growth Factor beta;translational potential;tumor;Tumor Antigens;urogenital tract;Vaccination;Virulence;Virus Diseases;Work

PROJECT_TITLE: Regulation and Function of Oral Resident Memory T Cells

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: HOUSTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Atrial fibrillation is the most common heart rhythm disorder in the United States with 1 in 4 adults at risk of disease development and is linked to serious debilitating complications like stroke and heart failure. For reasons we don’t yet understand, the developmental left/right patterning gene, PITX2, is linked to disease risk and recurrence following intervention late in life. In support of the NIH mission to promote better treatment and prevention strategies, my research study will use recent technological advances to study how PITX2-dependent patterning on the left side of the heart during development is required for a lifetime of normal heart rhythm.

PI_NAMEs: STEIMLE, JEFFREY DAVID (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Accounting;Address;Adult;Affect;Alleles;Animal Model;Arginine;arginine methyltransferase;Arrhythmia;Atrial Fibrillation;Binding;Binding Sites;biological adaptation to stress;Blood;Cardiovascular Diseases;Caring;Code;Complex;cost;curative treatments;Data;Data Set;design;Development;Disease;disorder risk;DNA;DNA Methylation;Early Intervention;Embryonic Atrium;Environment;Enzymes;Epigenetic Process;gastrulation;Gene Expression;gene regulatory network;gene repression;Genes;Genetic;Genetic Transcription;genome wide association study;genome-wide;Goals;Heart;Heart Atrium;Heart failure;heart rhythm;histone methylation;Histones;homeodomain;Homeostasis;Human;human disease;Immunoprecipitation;insight;Intervention;Ischemia;Knowledge;Lateral;Left;Left atrial structure;Life;lifetime risk;Link;Lung;Mass Spectrum Analysis;Mediating;Medicare;Mesoderm;Methods;Methylation;methylation pattern;methylome;Mission;Molecular;mouse model;Mus;mutant;Myocardium;novel;novel strategies;Outcome;Oxidative Stress;Oxygen;Pathologic;Pathway interactions;Patient Care;Pattern;Phenotype;Physiological;Predisposition;Prevention strategy;Pulmonary veins;rare variant;Reagent;recruit;Recurrence;Repression;research study;response;Right atrial structure;Risk;Role;Side;Site;Stroke;Structure;Technology;Testing;transcription factor;Transcription Repressor;treatment strategy;United States;United States National Institutes of Health;Variant;Veins;Work

PROJECT_TITLE: Left-right asymmetry and PITX2 in atrial fibrillation

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(MA)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Genetics;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: AMATRUDA, JAMES F (contact)

PROJECT_TERMS: Adolescent and Young Adult;adverse outcome;Affect;Applied Genetics;Beds;Behavior;Biological Assay;Biosensor;Bone Tissue;Buffers;Cancer Biology;cancer cell;caveolin 1;Caveolins;cell behavior;Cell Survival;Cells;Cellular Morphology;chemotherapy;Child;childhood sarcoma;Clinical Trials;Collaborations;Data;Disease;Disseminated Malignant Neoplasm;driver mutation;Embryo;Enabling Factors;Engraftment;Environment;Epigenetic Process;Event;Ewings sarcoma;Failure;Fishes;functional adaptation;Genetic;genetic manipulation;Genetic Models;Genome;genomic profiling;Goals;Heterogeneity;high resolution imaging;Human;Image;imaging capabilities;Imaging technology;In Situ;in vivo;insight;Intrinsic factor;Link;Malignant Bone Neoplasm;MAP Kinase Gene;Mechanics;Membrane;Metabolic;Metastatic/Recurrent;Microscopy;Morphology;mouse model;Multimodal Imaging;multimodality;Mus;Neoplasm Metastasis;neoplastic cell;novel strategies;Optics;optogenetics;Organ;Organism;Outcome;Oxygen;Pathway interactions;Patients;Pattern;Phenotype;Population;prevent;Primary Neoplasm;Property;quantitative imaging;Recurrence;Research;Resolution;Role;Sarcoma;Signal Pathway;Signal Transduction;Site;soft tissue;Survival Rate;System;Testing;Tissues;tool;Treatment-related toxicity;tumor;tumor microenvironment;tumor xenograft;Visit;Visualization;Whole Organism;WNT Signaling Pathway;Xenograft Model;Xenograft procedure;Zebrafish

PROJECT_TITLE: Cancer Biology Research Test-Bed Unit 1: Effects of cell-intrinsic and cell-extrinsic signaling and mechanics on metastasis patterns of pediatric sarcomas


NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Cardiovascular;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SEGREST, JERE P (contact)

PROJECT_TERMS: Academic Medical Centers;APOA5 gene;Apolipoprotein A-I;Apolipoprotein A-II;apolipoprotein A-IV;Apolipoprotein E;Apolipoproteins;Apolipoproteins A;Apolipoproteins C;Area;ATP-Binding Cassette Transporters;Back;Cardiovascular Diseases;Chemicals;Cholesterol;Collaborations;Computational Biology;Computer Simulation;crosslink;Data;Docking;Doctor of Philosophy;Exhibits;Experimental Models;experimental study;Goals;Grain;Heterogeneity;High Density Lipoproteins;Hour;improved;in silico;In Situ;interdisciplinary approach;ion mobility;Lipids;Literature;Maps;Membrane;Modeling;models and simulation;Molecular;Molecular Conformation;molecular dynamics;molecular modeling;novel;particle;Particle Size;Phospholipids;Process;Program Research Project Grants;programs;Property;Proteins;Research Personnel;Services;Structural Models;Structure;Testing;tool;translocase;Trefoil;Visualization

PROJECT_TITLE: Computational Biology Core


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Early midlife Black women 35-44 years old have more than double the prevalence of hypertension (HTN) compared to aged-matched White women, 48.3% versus 21.3%, respectively. Early onset HTN among early midlife Black women is linked to a higher burden of HTN-mediated organ damage and cardiovascular disease (CVD) morbidity and mortality; however, causes of these disparate outcomes remain unknown but may be due to the unequal burden of distinct stressors (i.e., racial, gender, financial, job, and social network) experienced by Black women. Repeated exposure to these distinct stressors are suggested to cause stress proliferation and modify the effects of health protective resources such as resilience that may lead to undesirable effects on physical health, thus, this K23 proposal seeks to quantify the impact of chronic stress burden and resilience on biologic and vascular aging using Klemera-Doubal estimation method, whether a person is biologically older or younger given their chronological age, and arterial stiffness, a proxy of CVD risk, in early midlife Black women.

PI_NAMEs: SPIKES, TELISA  (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: Adult;Adverse effects;Age;age acceleration;age-related disease;aged;Aging;aging process;aging related;arterial stiffness;Biological;biological age;Biological Aging;Biological Assay;Biometry;black men;Black race;black women;Blood Vessels;Buffers;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Chronic stress;Chronology;cohort;Creativeness;Cross-Sectional Studies;cytokine;Data;design;Disparity;early onset;Education;Environment;Estrogens;Exhibits;experience;Exposure to;Femur;Fostering;Functional disorder;Gender;Goals;Health;health equity;health equity promotion;Heart;heart disease risk;High Prevalence;high risk;Hypertension;Immune system;immunoregulation;Income;indexing;Inflammation;Inflammatory;Interview;Knowledge;Left Ventricular Hypertrophy;lens;Life;Life Cycle Stages;Linear Regressions;Link;Longitudinal cohort;low socioeconomic status;Measurement;Measures;Mediating;men;Mentored Patient-Oriented Research Career Development Award;Methods;middle age;Morbidity - disease rate;mortality;mortality risk;National Institute of Nursing Research;Occupations;Organ;Organism;Outcome;outcome disparities;Outcome Study;Pathogenicity;Pathway interactions;Pattern;perceived stress;Perception;Personal Satisfaction;Persons;physical conditioning;Physiologic pulse;Physiological;predictive marker;Predisposition;Prevalence;Process;Production;Proliferating;Proxy;Psychoneuroimmunology;psychosocial resources;Qualitative Methods;Race;Research;Research Methodology;resilience;Resources;response;Risk;Risk Factors;Role;skill acquisition;skills;social;social disparities;Social Environment;social health determinants;Social isolation;Social Network;Socioeconomic Status;socioeconomics;Source;standard measure;Stress;stress reduction;stressor;Structure;Subgroup;Sum;theories;Time;Training;Training Activity;United States;Venous blood sampling;Vulnerable Populations;White Women;Woman

PROJECT_TITLE: The Contribution of Chronic Stress and Psychosocial Resources on Aging in Young and Early Midlife Black Women

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(86)]


NIH_SPENDING_CATS: Atherosclerosis

PI_NAMEs: VAISAR, TOMAS  (contact)

PROJECT_TERMS: Abbreviations;analytical method;analytical tool;Apolipoprotein A-II;Apolipoproteins;Area;Binding;Bioinformatics;Biological;Biological Assay;Calibration;Cell Line;Chemicals;Cholesterol;Complex;cost effective;cost effectiveness;crosslink;Data;data integration;Data Set;Databases;Doctor of Philosophy;Electron Microscopy;Electrospray Ionization;gel electrophoresis;Genes;Goals;Grant;Hamsters;Heterogeneity;High Density Lipoproteins;Human;Human Resources;In Vitro;in vivo;Individual;instrumentation;interdisciplinary approach;ion mobility;Isotopes;Kidney;kidney cell;Knowledge;Laboratories;Lipoproteins;Liquid Chromatography;Mass Spectrum Analysis;Measurement;Methods;Mifepristone;Molecular;mutant;NMR Spectroscopy;Ontology;particle;Particle Size;Pathway Analysis;Peptides;Phospholipids;Plasma;Process;Program Research Project Grants;programs;protein protein interaction;Proteins;Proteome;Proteomics;Recombinant Proteins;Recombinants;reconstitution;Reproducibility;Research;Research Personnel;Services;Shotguns;Spectrometry;stable isotope;Standardization;stoichiometry;Structure;success;System;tandem mass spectrometry;Testing;Theoretical model;Universities;Washington

PROJECT_TITLE: Lipoprotein Quantitation and Function Core


NIH_SPENDING_CATS: Cancer;Nutrition;Skin Cancer

PI_NAMEs: MORRISON, SEAN J (contact)

PROJECT_TERMS: Address;Affect;Antioxidants;Beds;Biological Assay;Blood;Brain;Cancer Biology;cancer cell;Cancer Control;Cell Death;Cell Proliferation;Cell Survival;Cells;cellular imaging;Clinical Trials;Cytoprotection;Data;dietary;Distant;Environment;Exhibits;experience;Exposure to;Flow Cytometry;Hydrogen;Image;Immunocompetent;Immunocompromised Host;Impairment;In Situ;in vivo;Intervention;Kidney;lipid metabolism;Lipid Peroxides;lipidomics;Lipids;Liver;Location;Lung;Lymph;lymphatic vessel;Melanoma;Melanoma Cell;Melanoma patient;Membrane;Metabolic;Metastatic Melanoma;migration;Mitochondria;Monounsaturated Fatty Acids;Mus;Mutation;Neoplasm Metastasis;Oleic Acids;Organ;oxidation;Oxidation-Reduction;Oxidative Stress;Patients;Pattern;Phospholipids;Polyunsaturated Fatty Acids;Process;Proliferating;Property;Reactive Oxygen Species;Research;Resistance;Resolution;response;Site;technology development;Testing;Tissues;tumor progression;Variant;Xenograft procedure

PROJECT_TITLE: Cancer Biology Research Test-Bed Unit 2: Effects of cell-intrinsic and cell-extrinsic variations in lipid metabolism on metastasis patterns


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular

PROJECT_TERMS: Abbreviations;APOA5 gene;Apolipoprotein A-I;Apolipoprotein A-II;apolipoprotein A-IV;Apolipoprotein E;Apolipoproteins;Apolipoproteins A;Apolipoproteins C;Arteriosclerosis;ATP binding cassette transporter 1;ATP-Binding Cassette Transporters;Binding Proteins;Biochemical;Biological;biological standardization;Charge;Cholesterol;cost;cost effectiveness;Cryoelectron Microscopy;design;Doctor of Philosophy;experience;Generations;Goals;Heterogeneity;High Density Lipoproteins;Human;Individual;Infrastructure;interdisciplinary approach;Isotope Labeling;Laboratories;Lead;Lecithin;Lipids;Lipoproteins;Mass Spectrum Analysis;molecular dynamics;Mutagenesis;mutant;nanobodies;particle;Peptides;Phosphatidylcholine-Sterol O-Acyltransferase;Plasma;Polymerase Chain Reaction;Price;Process;Production;Program Effectiveness;Program Research Project Grants;programs;Proteins;Publishing;Reagent;Recombinants;reconstitution;Research;Research Personnel;Resources;Running;Sampling;Science;Services;Site;Source;Structure;Surface;synergism;Techniques;Testing;Time;Universities;Work

PROJECT_TITLE: Apo/Lipoprotein Production Core


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Parkinson's Disease;Precision Medicine

ORG_CITY: ROCHESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative Constructing reliable individualized treatment strategies requires studies with fairly large sample sizes with longi- tudinal assessment of subjects over a relatively long period of time. To this end, we will create a harmonized and curated dataset by integrating data from seven long-term observational and randomized studies in Parkinson's disease. Using this harmonized data, we will develop and apply robust, rigorous and computationally efﬁcient methods for estimating an optimal individualized treatment strategy for Parkinson's disease with respect to var- ious outcomes (e.g., Uniﬁed Parkinson's Disease Rating Scale, quality of life, and Schwab and England ADL score). We will also leverage statistical machine learning approaches to improve the quality of the constructed optimal individualized treatment strategy while providing valid statistical inference.

PI_NAMEs: ERTEFAIE, ASHKAN ;MCDERMOTT, MICHAEL P;VENUTO, CHARLES STANLEY (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: Adoption;Alzheimer's Disease;analytical method;Behavior;Benefits and Risks;care providers;Caring;Characteristics;Clinic Visits;Clinical;clinical care;Clinical Data;clinical decision-making;clinical phenotype;Clinical Research;clinical research site;Clinical Trials;Code;comparative;comparative effectiveness study;Comparative Study;Complex;Computer software;Coupled;Data;Data Analyses;Data Collection;data curation;data harmonization;data integration;data management;Data Set;Decision Making;Decision Trees;demographics;Disease;dosage;England;flexibility;follow-up;Future;Goals;Guidelines;Health;Heterogeneity;improved;Individual;individualized medicine;Journals;Language;Learning;longitudinal dataset;Longterm Follow-up;machine learning method;Measurement;Measures;Medical;Medicine;Methodology;Methods;Modeling;Movement Disorder Society Unified Parkinson's Disease Rating Scale;Multi-site clinical study;Nature;Nervous System Disorder;Observational Study;open source;Outcome;Output;Parkinson Disease;Participant;patient response;Patients;Pattern;permissiveness;personalized approach;personalized medicine;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phenotype;Population;Procedures;Process;progression marker;Protocols documentation;Publications;Quality of life;Randomized;Recommendation;Recording of previous events;Relaxation;repository;Research;Research Personnel;response;Sample Size;Sampling;software development;Software Tools;Source;statistical and machine learning;Syndrome;Target Populations;Techniques;Therapeutic;Time;tool;treatment planning;treatment response;treatment strategy

PROJECT_TITLE: Advancing Personalized Medicine in PD Using Harmonized Multi-Site Clinical Data


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PI_NAMEs: SMITH, SUSAN  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Cellular biology;Training Programs

PROJECT_TITLE: Training Program in Cell Biology

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


PI_NAMEs: HEINECKE, JAY W (contact)

PROJECT_TERMS: Animals;Anti-Inflammatory Agents;Apolipoprotein A-I;Apolipoprotein A-II;Apolipoproteins;Arteries;atheroprotective;Atherosclerosis;ATP binding cassette transporter 1;ATP-Binding Cassette Transporters;Calibration;Cardiac Death;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cell membrane;Chemicals;Cholesterol;cohort;Complement;Complications of Diabetes Mellitus;Confounding Factors (Epidemiology);Cox Models;crosslink;Data;Diabetic mouse;dimer;Epidemiology;Goals;hazard;Heart;Heterogeneity;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Human;humanized mouse;in vivo;Inflammation;insight;Insulin-Dependent Diabetes Mellitus;interdisciplinary approach;interest;ion mobility;Isomerism;Lipids;Liver;Macrophage;Measures;Mediating;Methods;molecular modeling;Molecular Sieve Chromatography;mouse model;Mus;Myocardial Infarction;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Obesity;oxidation;particle;Pathway interactions;Patients;Pharmaceutical Preparations;Phosphatidylcholine-Sterol O-Acyltransferase;Phospholipids;Plasma;Play;Population;premature;Property;Prospective Studies;Proteins;Proteolysis;revascularization;reverse cholesterol transport;Risk;Risk Assessment;Risk Factors;Role;Structure;Study models;sudden cardiac death;targeted treatment;Testing;Therapeutic;therapeutic target;tool;type I and type II diabetes;Validation

PROJECT_TITLE: Cardioprotection by extra-small HDL particles


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Contraception/Reproduction;Diabetes;Genetics;Maternal Health;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE  Obesity is a key risk factor for gestational diabetes. Although both insulin resistance and insulin insufficiency are two primary underlying mechanisms of gestational diabetes, β-cell dysfunction leads to hyperglycemia. This project is designed to define adiponectin's regulatory effects on maternal β-cell adaptation and the contribution of hypoadiponectinemia in obesity-associated gestational diabetes.

PI_NAMEs: SHAO, JIANHUA  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Adipocytes;adiponectin;Adverse effects;Agonist;Alpha Cell;Attenuated;Beta Cell;Blood;Cell Proliferation;Cells;Circulation;Communication;conditional knockout;Cultured Cells;Data;Defect;design;Endocrine;extracellular vesicles;Failure;Fatty acid glycerol esters;First Pregnancy Trimester;Functional disorder;Funding;Gene Expression;Genes;Genetic;Gestational Diabetes;Glucagon;glucagon-like peptide 1;Glucose;glucose metabolism;glucose tolerance;Health;Hormone secretion;Human;Hyperglycemia;improved;In Vitro;Insulin;Insulin Resistance;insulin secretion;islet;Islet Cell;Knock-out;knockout gene;lipid metabolism;Mediating;Metabolic;Metabolic stress;Metabolism;MicroRNAs;miRNA expression profiling;mouse model;Mus;Obesity;Obesity Epidemic;offspring;Organ;Pancreas;paracrine;Pathologic;Pathway interactions;Placenta;Placental Lactogen;Postpartum Period;Pregnancy;Pregnancy Outcome;pregnant;Prevalence;Production;receptor;Reporting;Research;Risk Factors;Role;Second Pregnancy Trimester;Structure of alpha Cell of islet;success;Tissues

PROJECT_TITLE: Hypoadiponectinemia and Gestational Diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-C(02)M]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Microbiome;Nutrition;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Haitian immigrants to the US, who comprise one of the fastest-growing and most-understudied immigrant subgroups in the country, experience high levels of post-migration psychological distress (i.e., depression, anxiety, fatigue, and pain), which contribute to progressive functional impairment, disability, economic burden, and poor long-term health outcomes. Evidence suggests that the gut microbiome (GM; i.e., the collective genomes of microbes living in the gut) plays an important role in the development and persistence of psychological distress and, further, that the GM is modifiable through interventions targeting social determinants of health (SDoH) like stress, lifestyle behaviors, dietary patterns, environmental/sociocultural conditions, and sociodemographic characteristics. The present study will investigate associations between psychological distress, the GM, and post-migration SDoH in recent Haitian immigrants to the US as a critical step in developing culturally responsive, personalized interventions to mitigate psychological distress, improve long-term health outcomes, reduce health disparities, and increase health equity in this underserved population.

PI_NAMEs: FANFAN, DANY  (contact)

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: Acculturation;Achievement;Address;Adopted;Anxiety;Area;Asian population;Behavior;Behavior Therapy;biobehavior;Bioinformatics;Biological Process;Characteristics;Cohort Studies;Country;Cultural Characteristics;culturally appropriate intervention;Development;Diet Habits;Dietary Practices;disability;Disabling;Economic Burden;Education;Employment;ethnic minority;experience;Exposure to;Fatigue;Foundations;Functional impairment;Future;Genomics;Goals;gut microbiome;gut-brain axis;Haitian;Health;health disparity;health equity;Health Promotion;Healthy Eating;holistic approach;Home;Household;Immigrant;Immigration;improved;Income;Intervention;Knowledge;Latina Population;Latino Population;Length;Life Style;Link;Mental Depression;Mentors;microbial;microbial genome;microbiome composition;microbiota;migration;Nursing Research;Outcome;Pain;perceived stress;Personal Satisfaction;personalized intervention;Persons;Phylogenetic Analysis;Physical activity;Play;Policies;Population;Psyche structure;psychological distress;psychosocial;Quality of life;Reduce health disparities;Reporting;Research;Research Personnel;residence;Ribosomal RNA;Risk;Role;Science;Senior Scientist;Services;social culture;Social Environment;social health determinants;sociodemographic factors;sociodemographics;stool sample;Stress;stressor;Subgroup;symptom science;Symptoms;Time;tool;Training;Translating;translational research program;Underserved Population;United States;Work

PROJECT_TITLE: Examining the Gut Microbiome in Haitians Post-Migration to the United States

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(83)]


ORG_CITY: ANN ARBOR

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Public Health Relevance Infertility affects one in six couples worldwide, with men and women equally likely to have fertility problems. In men, known genetic factors account for ~10-15% of total infertility cases, whereas the remaining ~35-40% cases have an unknown etiology. Therefore, a comprehensive understanding of the genetic and molecular programs involved in proper germ cell development is required for development of better diagnostics and effective therapies.

PI_NAMEs: HAMMOUD, SAHER SUE (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Affect;Antibodies;Appearance;ATP phosphohydrolase;Back;Binding;Biochemical;biochemical tools;Biological Assay;biophysical properties;biophysical tools;Cells;ChIP-seq;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Complex;Couples;Data;Deposition;Development;Diagnostic;DNA;DNA Packaging;effective therapy;egg;Epitopes;Etiology;Event;Excision;Fertility;Generations;Genetic;Genome;Genomic Segment;genomic tools;Genotype;Germ Cells;Global Change;Goals;Haploidy;Histones;Immunoprecipitation;In Vitro;in vivo;Infertility;insight;Investigation;ISWI;Kinetics;Knock-out;Knowledge;Label;laser tweezer;loss of function;Mass Spectrum Analysis;Mediating;Meiosis;men;Methods;Mitosis;Modeling;Molecular;Molecular Chaperones;Mus;mutant;novel;Nucleosomes;Oocytes;optic tweezer;Pattern;Phenotype;Physical condensation;Population;Positioning Attribute;PRM2 gene;Process;Production;programs;protamine 1;Protamines;Protein Subunits;Proteins;public health relevance;Publishing;Reagent;Recombinant Proteins;reconstitution;reproductive fitness;Role;Sexual Reproduction;single molecule;single-cell RNA sequencing;Slide;SMARCA5 gene;Somatic Cell;sperm cell;Spermatids;Spermiogenesis;Testing;Testis;Woman

PROJECT_TITLE: Mechanisms of sperm chromatin remodeling in vivo and in vitro


ORG_DEPT: UROLOGY

PHR: The rapid uptake of telehealth since the coronavirus pandemic has highlighted not only the potential for telehealth to improve access and quality of care, but also how it can exacerbate the “digital divide,” highlighting the need to focus on health equity. Using the largest integrated health care system in the US [Veterans Health Administration (VA)] as a clinical practice network, we will focus on race/ethnicity, poverty and rurality and how they affect use of telehealth, which we refer to as social determinants of telehealth (SDTH). We propose a Center called Telehealth Research and Innovation for Veterans with Cancer (THRIVE), whose overarching aim is two-fold: 1) understand how SDTH impact the delivery of telehealth for cancer and 2) develop methods to address SDTH and thereby improve access and quality of cancer care for all patients.

PI_NAMEs: MAKAROV, DANIL V.;SHERMAN, SCOTT E (contact);ZULLIG, LEAH L.

PROGRAM_OFFICER_NAME: JENSEN, ROXANNE ELAINE

PROJECT_TERMS: Academy;Address;adverse outcome;Affect;Breast;cancer care;Cancer Control;Caring;Cause of Death;clinical practice;Colon;Communication;Consolidated Framework for Implementation Research;Continuity of Patient Care;coronavirus pandemic;Data;digital divide;Disadvantaged;Discrimination;Disparity;disparity reduction;Early Diagnosis;Economic Factors;Environmental Risk Factor;Ethnic Origin;experience;Funding;Health;health care availability;health care delivery;health care disparity;Health Disparities Research;health disparity;health equity;health inequalities;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;implementation science;implementation strategy;Improve Access;improved;innovation;Integrated Health Care Systems;Investments;Laboratories;learning network;Lung;Malignant Neoplasms;Medical center;Medicine;Methods;National Institute on Minority Health and Health Disparities;next generation;Oncology;oncology program;Outcome;Outpatients;Patient Care;Patients;Pattern;Perception;Persons;Population;Poverty;pragmatic trial;Prostate;Provider;Quality of Care;Race;racial disparity;recruit;Research;Research Methodology;Research Personnel;rurality;screening;Site;social;social determinants;social factors;social health determinants;Social status;structural determinants;survivorship;System;telehealth;telehealthcare;Testing;Training;Trust;uptake;Veterans;Veterans Health Administration;virtual;virtual health;virtual healthcare;willingness


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Telehealth

PI_NAMEs: SHERMAN, SCOTT E (contact)

PROJECT_TERMS: Agreement;Budgets;clinical practice;Communication;Data;Development Plans;Ensure;Faculty;Feedback;Goals;health equity;Health system;Healthcare Systems;innovation;Institutional Review Boards;Malignant Neoplasms;meetings;Mentors;Monitor;Office of Administrative Management;Oncology;Pilot Projects;pragmatic trial;Regulation;Research;Research Methodology;Research Training;Safety;Schedule;telehealth;Training;Veterans;Veterans Health Administration;virtual healthcare;Work

PROJECT_TITLE: Administrative Core - Telehealth Research and Innovation for Veterans with Cancer (THRIVE)


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health;Telehealth

PI_NAMEs: ZULLIG, LEAH L. (contact)

PROJECT_TERMS: access disparities;Address;Administrator;Affect;age effect;built environment;cancer care;Cancer Care Facilities;cancer diagnosis;cancer health disparity;Cancer Model;cancer prevention;care delivery;care outcomes;care systems;Caring;Clinic;Clinical;Collaborations;Colorectal Cancer;Communication;Communities;contextual factors;Development;Disadvantaged;disparity reduction;Economics;Education;effective intervention;Ensure;Environment;Equity;Ethnic Origin;Evaluation;experience;genetic testing;Geography;Health;health administration;health care availability;health care service;health communication;Health Disparities Research;health equity;Health Sciences;Healthcare;Healthcare Systems;implementation science;Individual;innovation;Integrated Health Care Systems;Intervention;Laboratories;Location;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medical center;medical schools;Mission;multidisciplinary;National Institute on Minority Health and Health Disparities;Neighborhoods;New York;Newly Diagnosed;novel;Oncology;oncology program;Outcome;Persons;Pharmaceutical Preparations;Pilot Projects;Play;Population Density;Poverty;Price;Provider;Quality of Care;Quality of life;Race;racial minority;Research;Research Methodology;rural area;rurality;scale up;screening;social;Social Controls;social culture;social determinants;social health determinants;socioeconomics;stakeholder perspectives;survivorship;telehealth;Universities;Veterans;Veterans Health Administration;virtual delivery;Vision;Work

PROJECT_TITLE: Research and Methods Core - Telehealth Research and Innovation for Veterans with Cancer (THRIVE)


PI_NAMEs: DAVIDSON, W SEAN (contact)

PROJECT_TERMS: Affect;Apolipoprotein A-I;Apolipoprotein A-II;Apolipoproteins;Arteries;atheroprotective;ATP-Binding Cassette Transporters;Binding;Biological Assay;C-terminal;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;Cell Physiology;Cells;Characteristics;Chemosensitization;Cholesterol;Clinical Trials;Cryoelectron Microscopy;Cultured Cells;Data;Deuterium;Diabetes Mellitus;Diameter;Excision;experimental study;Family;Goals;Heterogeneity;High Density Lipoproteins;Human;Hydrogen;in silico;in vivo;innovation;Insulin-Dependent Diabetes Mellitus;interdisciplinary approach;interest;Knowledge;Learning;Lipids;Lipoprotein (a);Lipoproteins;Macrophage;Mediating;member;Modeling;Molecular;Molecular Conformation;mouse model;Mus;Mutation;Myocardial Infarction;novel;novel therapeutic intervention;particle;Particle Size;Patients;Peptides;physical property;Physiological;Plasma;Population;Program Research Project Grants;promoter;Proteins;Proteolysis;Proteomics;reconstitution;Resolution;risk prediction;Role;Scaffolding Protein;Stroke;Structure;Sudden Death;Surface;Techniques;Technology;Testing;Therapeutic;therapy design;Visualization;Work

PROJECT_TITLE: Mechanism of ABCA1-mediated CEC to lipidated HDL particles


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Comparative Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Social Determinants of Health;Telehealth;Women's Health Research

PI_NAMEs: MAKAROV, DANIL V. (contact)

PROJECT_TERMS: Accounting;Administrator;Affect;Attitude;Behavior;Breast;cancer care;Cancer Center;cancer health disparity;cancer subtypes;cancer therapy;care coordination;Caring;Cessation of life;Client satisfaction;Clinical Services;Colon Carcinoma;Colorectal;Colorectal Cancer;Communication;Continuity of Patient Care;cost;cost outcomes;COVID-19 pandemic;Diagnosis;digital divide;Disparity;effectiveness evaluation;effectiveness testing;effectiveness/implementation study;effectiveness/implementation trial;Equity;Ethnic Origin;experience;Goals;hands-on learning;health care disparity;health care service utilization;Health Disparities Research;health equity;health equity promotion;health management;Health Personnel;Health Services Accessibility;Healthcare Systems;Home;implementation outcomes;improved;Individual;innovation;Integrated Health Care Systems;Intervention;intervention cost;Intervention Studies;Interview;Knowledge;Label;Leadership;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medical;men;Methods;Mission;Modeling;mortality;National Institute on Minority Health and Health Disparities;Oncology;oncology program;Outcome;Participant;Patient Care;Patients;Performance;Play;population health;Populations at Risk;Poverty;pragmatic trial;Program Sustainability;programs;Prostate;Provider;Public Health;Race;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;risk minimization;Role;rurality;satisfaction;screening;service delivery;Services;Single-Payer System;social determinants;social health determinants;Structure;successful intervention;telehealth;teleoncology;Time;United States;Veterans;Veterans Health Administration;virtual;virtual delivery;Visit;Vulnerable Populations;Woman

PROJECT_TITLE: Pragmatic Trial - Telehealth Research and Innovation for Veterans with Cancer (THRIVE).


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Contraception/Reproduction;Infertility;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Rehabilitation;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Adult survivors of childhood cancer are a growing population who face a number of long-term and late effects secondary to their cancer treatment, which have the potential to profoundly impact their future health, quality of life, and achievement of life goals. This project will examine the initial feasibility, acceptability, and pre- to post- intervention patterns of change in treatment targets of a novel behavioral intervention aiming to address fertility-related information needs and fertility-related distress among adult survivors of childhood cancer. Although this project is focused on the late effect of impaired fertility, the intervention developed through this study has the potential to produce significant public health benefits: it could be applied to address other late effects in this population, which if left untreated, may lead to greater health complications in this growing population later in life.

PI_NAMEs: STALLS, JULIANN  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: acceptability and feasibility;Achievement;Address;Adult;Adult women;aged;Area;Behavior Therapy;Behavioral Model;Biological;Cancer Patient;Cancer Survivor;Cancer Survivorship;cancer therapy;career;Caregivers;Caring;Child;child bearing;childhood cancer survivor;Clinical;Cognitive;combination intervention strategy;Communication;cost;Data;design;Development;Diagnosis;Distress;Emotional;Evaluation;evidence base;Feedback;Fellowship;Female;Fertility;fertility improvement;fertility preservation;flexibility;Foundations;Future;Gatekeeping;Goals;Grief reaction;Guilt;Health;Health Benefit;health knowledge;Impairment;improved;Individual;Infertility;Intervention;intervention refinement;Interview;Knowledge;Late Effects;Lead;Left;Length;Life;Link;Literature;Malignant Childhood Neoplasm;Malignant Neoplasms;Manuals;Medical;Mental Depression;Modality;Modeling;motherhood;National Cancer Institute;novel;oocyte cryopreservation;Ovarian tissue cryopreservation;Patients;Pattern;Phase;phase 1 study;Population;post intervention;prepuberty;preservation;primary ovarian insufficiency;Provider;psychologic;Puberty;Public Health;Quality of life;Questionnaires;Reporting;Reproductive Health;Research Personnel;Research Priority;Resources;Risk;Risk Estimate;Role;Sampling;Secondary to;Self Efficacy;Sexual Health;side effect;skills;Stress;Structure;Survivors;survivorship;Target Populations;Testing;theories;therapy design;therapy development;Time;Training;training opportunity;Universities;Woman;women's treatment

PROJECT_TITLE: Addressing Fertility Information Needs and Fertility-related Distress among Female Adult Survivors of Childhood Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(21)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Primary Health Care;Social Determinants of Health;Telehealth

PROJECT_TERMS: Cancer Control;Cancer Patient;care coordination;care systems;Caring;Clinical;clinical practice;Clinical Research;colorectal cancer screening;connected care;Decentralization;Discipline of Nursing;Education;Electronic Health Record;electronic health record system;Eligibility Determination;Enrollment;Environment;Equity;Funding;geographic barrier;Goals;Health;Health care facility;health equity;Health Insurance;Health system;Healthcare;Healthcare Systems;Hematology;improved;Individual;Informatics;innovation;Integrated Health Care Systems;Learning;Malignant Neoplasms;Managed Care;Measurement;Measures;Medical center;medical specialties;Methods;military veteran;Mission;Modeling;multidisciplinary;Oncology;oncology program;operation;Outpatients;Patient Care;patient centered medical home;patient population;Patient Recruitments;Patient-Centered Care;Patients;Peer Review;Performance;Pharmacy facility;Physicians;Primary Care;primary care team;process improvement;programs;Quality of Care;Radiation Oncology;recruit;Research;Research Activity;safety net;Services;Site;social;Social Psychology;Social Work;Source;Surgical Oncology;System;Technology;telehealth;teleoncology;tool;Training;United States;Variant;Veterans;Veterans Health Administration;virtual;virtual healthcare

PROJECT_TITLE: Clinical Practice Network - Telehealth Research and Innovation for Veterans with Cancer (THRIVE)


ADMINISTERING_IC: LM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: RICE UNIVERSITY

PHR: PROJECT NARRATIVE Our NLM Research Training Program in Biomedical Informatics (BMI) and Data Science (DS) has successfully brought the theory and practice of computation, applied mathematics, statistics, data-driven inference and decision-making, and advances in cognitive informatics, to bear on problems in human health and disease that are currently beyond our reach. We will further expand our program to explore and exploit the dynamic interaction of multiple facets of BMI and DS with the current methodologies, tools, and computational approaches of artificial intelligence including machine learning, and their synergistic applications in biomedicine and human health and disease, including precision medicine, clinical decision-making and data-driven health. This program provides the unique opportunity for pre- and postdoctoral trainees to acquire the skills, expertise and intellectual abilities to foster innovative research and prepare them for a wide range of BMI careers that significantly impact basic research, patient healthcare, and public health, by: pursuing core courses in BMI and DS and advanced electives, training in rigor and reproducibility and the responsible conduct of research, professional/career development activities, and dual-mentored inter-disciplinary research projects in health care/clinical informatics, translational bioinformatics, and clinical research informatics.

PI_NAMEs: KAVRAKI, LYDIA E. (contact)

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Affect;Applied Research;Appointment;Area;Artificial Intelligence;Basic Science;Bioinformatics;biomedical informatics;Body mass index;career;career development;Career Mobility;Clinical;clinical decision-making;Clinical Informatics;Clinical Research;Cognitive;Collaborations;Coupled;Data;Data Science;Decision Making;Disease;Ensure;Evaluation;experience;experimental study;Faculty;Fostering;Foundations;Funding;Future;Generations;Health;Healthcare;Human;Informatics;innovation;Institution;invention;Knowledge;Knowledge acquisition;Machine Learning;Mathematics;meetings;Mentors;Methodology;Modeling;Patient Care;personalized medicine;Postdoctoral Fellow;pre-doctoral;Productivity;programs;Public Health;recruit;Reproducibility;Research;Research Project Grants;Research Training;responsible research conduct;Scientist;skill acquisition;Solid;Statistical Methods;statistics;Students;Teacher Professional Development;theories;tool;Training;Training Programs;Underrepresented Populations;United States National Library of Medicine;Woman;Work

PROJECT_TITLE: NLM Research Training Program in Biomedical Informatics and Data Science for Predoctoral and Postdoctoral Fellows


ED_INST_TYPE: OVERALL MEDICAL

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Aging is associated with the breakdown of the DNA in the nucleus of the cells. The broken pieces of DNA are released into the cytoplasm of the cells, where it is sensed by a set of specific proteins that initiate a cascade of events that leads to inflammation and aging of cells, organs, and organisms. Our goals are to identify the sites of these DNA breaks in the heart cells, characterize features of the cytosolic DNA, and block the activated pathway to assess its effects on the biological process related to aging.

PI_NAMEs: MARIAN, ALI J (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: age related;Aging;Antibodies;Attenuated;Autophagocytosis;Biological Process;Cardiac;Cardiac Myocytes;Cardiovascular system;CCCTC-binding factor;Cell Aging;Cell Death;Cell Nucleus;cell type;Cells;chromatin immunoprecipitation;Code;cohesin;cytokine;Cytoplasm;Cytosol;Defect;design;detection of nutrient;DNA;DNA Double Strand Break;DNA Transposable Elements;Endothelial Cells;env Gene Products;Epigenetic Process;Event;Fibroblasts;Fibrosis;Gene Expression;Genes;Genetic;genome integrity;Genome Stability;genome-wide;Genomic Instability;Goals;hallmarks of aging;Heart;heart cell;heart function;Histone Deacetylase;Human;Impairment;Inflammation;Inflammatory;insight;IRF3 gene;Knock-in;Lamin Type A;Length;Link;Logic;Maps;Mechanics;Methylation;Mitochondria;Mitochondrial DNA;Molecular;Morbidity - disease rate;mortality;mouse model;Mutation;NF-kappa B;normal aging;Nuclear;Nuclear Envelope;Organ;Organism;Pathogenesis;pathological aging;Pathway interactions;Phenotype;premature;Premature aging syndrome;Proteins;prototype;repaired;Resolution;Role;senescence;senescence associated secretory phenotype;Sirtuins;Site;Source;Spliced Genes;stem cell self renewal;STING1 gene;TBK1 gene;telomere;Testing;Transcription Initiation Site;transcriptome sequencing;Wild Type Mouse

PROJECT_TITLE: Cytosolic DNA is the Link Between Genomic Instability and Cardiovascular Aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-Z(52)]


PI_NAMEs: SEGREST, JERE P (contact)

PROJECT_TERMS: Apolipoprotein A-I;Apolipoprotein A-II;Apolipoproteins;ATP-Binding Cassette Transporters;Binding;Binding Sites;cardiovascular disorder risk;Cell membrane;Cells;Chemicals;Cholesterol;Clinic;Clinical Pathways;Collaborations;Communication;Computer Models;crosslink;Cryoelectron Microscopy;Cultured Cells;Data;Detergents;Diabetes Mellitus;dimer;Dimerization;Disparate;experimental study;extracellular;Extracellular Domain;Failure;Family;Goals;Grain;Heterogeneity;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Homeostasis;Human;Hydrophobicity;in silico;In Vitro;interdisciplinary approach;Isotopes;lipid transport;Lipids;Lipoproteins;Liposomes;Macrophage;Measures;Mediating;Membrane;Micelles;Modeling;Molecular;molecular dynamics;Mutagenesis;nanodisk;nanosized;Nature;novel;particle;Phospholipids;Plasma;Plasma Cells;Point Mutation;Production;programs;Publications;Radiolabeled;reconstitution;Resolution;Scheme;Series;Site;Structure;System;Testing;translocase;Validation;Variant;Visualization;Work

PROJECT_TITLE: Mechanisms of phospholipid/cholesterol translocation by ABCA1


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The Cardiovascular Development Data Resource Center (CDDRC) will provide an innovative cloud-based platform to facilitate the analysis, visualization and sharing of genomic data from research in heart development in several species. The CDDRC will bring together researchers with a diverse range of expertise, with the goal of understanding the causes of congenital heart disease in children.

PI_NAMEs: MARTH, GABOR T;TRISTANI-FIROUZI, MARTIN ;YOST, H. JOSEPH  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Acceleration;Address;Affect;Alligators;analytical tool;Basic Science;Bioinformatics;cardiogenesis;Cardiovascular system;Chickens;Child;Childhood;Chromatin;Chromatin Remodeling Factor;Client;Clinical;clinical phenotype;cloud based;Collaborations;Communities;Complex;Computational Biology;Computational Science;congenital heart abnormality;Consultations;Country;Data;data resource;Data Set;data warehouse;Databases;design;Development;Discipline;Disease;DNA;Education;Epigenetic Process;epigenome;ethical, legal, and social implication;Etiology;exome sequencing;experience;experimental study;follow-up;Future;gene discovery;Genetic;Genetic Diseases;genetic variant;Genome;genome sciences;genome sequencing;genomic data;Genomics;Goals;Heart;Human;human data;Human Genetics;Human Genome;human genomics;Individual;innovation;Institution;Internships;Intuition;Investments;Leadership;Link;meetings;methylome;Minority Health Research;model organism;Molecular;mosaic;Multiomic Data;multiple datasets;multiple omics;Mus;mutant;National Heart, Lung, and Blood Institute;Native Americans;next generation;next generation sequencing;online tutorial;Organism;Outcome;Outcomes Research;outreach;outreach program;Parents;Patients;Pediatric Cardiac Genomics Consortium;Pilot Projects;Preparation;programs;Rana;recruit;Research;Research Personnel;Resources;Science;Science of genetics;Scientist;Sheep;summer research;tool;tool development;Training;transcription factor;transcriptome;Turtles;Underrepresented Populations;Underrepresented Students;United States;Universities;Utah;virtual;Visual;Visualization;Visualization software;whole genome;Zebrafish


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PUBLIC HEALTH RELEVANCE/PROJECT NARRATIVE Diabetes care is complex and requires a multidimensional approach, but interventional programs are difficult to initiate in low-income and minority populations. In the proposed study, we will mentor local clinics via telehealth to initiate our diabetes program, TIME (Telehealth-supported, Integrated CHWs, Medication-access, group visit Education), into their clinics. Mentoring local clinics to initiate TIME is a promising strategy to enhance sustainable diabetes care and reduce disparities in vulnerable minority populations.

PI_NAMEs: VAUGHAN, ELIZABETH M (contact)

PROGRAM_OFFICER_NAME: ARTIS DICKERSON, SHAVON

PROJECT_TERMS: access disparities;Address;Adherence;Adult;Albumins;American;Appointment;arm;barrier to care;Blood Pressure;Body mass index;Caring;Cholesterol;Clinic;Clinical;clinical efficacy;Communication;Communities;community clinic;Community Health Aides;comparison intervention;Complex;cost effective;COVID-19;COVID-19 pandemic;Data;Development;diabetes education;Diabetes Mellitus;Diagnosis;Dimensions;disorder risk;Disparity;disparity reduction;Education;efficacy evaluation;enhanced care;Ethnic Origin;Evaluation;Expenditure;Face;foot;Fright;Frontline worker;glycemic control;Glycosylated hemoglobin A;Guidelines;Health Expenditures;Health Services Accessibility;Healthcare;Healthcare Systems;Human Resources;improve minority health;improved;Income;Individual;influenza virus vaccine;innovation;interest;International;Intervention;intervention participants;intervention program;Investigation;Knowledge;Latino;Left;literacy;longitudinal care;Low income;Low Income Population;Measures;Medical;member;Mentors;mHealth;Minority;Minority Groups;minority healthcare;Modality;multidisciplinary;Non-Insulin-Dependent Diabetes Mellitus;ophthalmic examination;Outcome;pandemic disease;Participant;Patient Care;Patients;Pharmaceutical Preparations;Poverty;pragmatic implementation;Prevalence;primary outcome;Program Acceptability;Program Evaluation;programs;Provider;Public Health;public health relevance;Randomized;randomized, clinical trials;Research;Sampling;satisfaction;Structure;telehealth;Testing;Texas;Time;Training;treatment as usual;urinary;Videoconferencing;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Evaluating telementoring to initiate a multidimensional diabetes program for Latino(a)s in community clinics: A Randomized Clinical Trial

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Understanding how the latent HIV reservoir forms is critical to developing new strategies to eliminate infected cells from people with HIV. Recent data has shown that the majority of the reservoir forms in a defined temporal window that coincides with the initiation of anti-retroviral therapy (ART). In this proposal, we aim to define transcriptional and epigenetic changes that occur in CD4 T cells during ART initiation by characterizing longitudinal samples from a clinical cohort and reveal how the intracellular state of CD4 T cells promotes viral silencing and epigenetic repression of HIV.

PI_NAMEs: BROWNE, EDWARD P (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: acute infection;antiretroviral therapy;ATAC-seq;Biological Assay;CD4 Positive T Lymphocytes;Cell Compartmentation;Cell division;Cells;Chromatin;Chromatin Structure;Cleavage Under Targets and Release Using Nuclease;Clinical;Clonal Expansion;Code;cohort;Data;Data Set;Effector Cell;Epigenetic Process;epigenetic silencing;Evolution;Gene Expression;Gene Silencing;Genes;Genetic Transcription;genome-wide;genome-wide analysis;Global Change;Goals;Heritability;heritability pattern;Histone Code;histone modification;Histones;HIV;HIV Genome;HIV Infections;in vivo;Inflammation;insight;Laboratories;latent HIV reservoir;Link;Maintenance;Maps;Memory;Methods;Modification;multiple omics;novel;novel strategies;novel therapeutics;Outcome;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Phenotype;prevent;Process;Property;Repression;Resolution;Rest;Sampling;Series;Shapes;single-cell RNA sequencing;Tail;Testing;Time;transcription factor;transcriptome sequencing;transcriptomic profiling;transcriptomics;transmission process;Viral;Viral Antigens;Viral reservoir;Virus

PROJECT_TITLE: Understanding HIV reservoir formation by profiling transcriptomic and epigenetic changes in CD4 T cells following ART initiation

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Neurosciences;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The University of Chicago (UChicago) Center for Asian Health Equity (CAHE) and the Institute for Population and Precision Health (IPPH) put forth the Chicago AsA-NHPI Cohort CCFS to leverage decades of experience enrolling underrepresented minorities, especially Asian Americans, into health studies and epidemiologic cohorts as a clinic/community field site for the new NIH-funded AsA-NHPI Cohort (NAC). We plan to enroll 2,500 participants from communities in the metropolitan Chicago area with large Asian subgroup representation using a population-based sampling framework. Our long-term partner, the Asian Health Coalition (AHC) has been serving as the national engagement lead for the All of Us Research Program and has set the model for community engaged cohorts tailored to Asian inclusion. In this proposal, the UChicago MPIs and team enthusiastically propose a collaborative approach to meet the milestones; building on prior success and experience working on local, regional and national multisite cohorts with an emphasis on racial diversity, scientific rigor, and innovative approaches to improve health disparities.

PI_NAMEs: ASCHEBROOK-KILFOY, BRISEIS A (contact);KIM, KAREN E

PROGRAM_OFFICER_NAME: YAN, YE

PROJECT_TERMS: Address;Adopted;Adult;Advocacy;Agreement;All of Us Research Program;Ancillary Study;Area;Asian;Asian Americans;Asian population;Behavioral;bilingualism;biobank;Cambodian;Censuses;Chicago;Clinic;Clinical;Clinical Protocols;cohort;Cohort Studies;Collaborations;collaborative approach;Communities;community advisory board;community based participatory research;community engagement;community partners;community partnership;community setting;Complement;Consent;cost;cultural competence;Data;Data Collection;design;Development;Disease;Disparity;diverse data;Documentation;Enrollment;Ensure;Epidemiology;Equilibrium;ethnic diversity;experience;Filipino;Focus Groups;follow-up;Funding;Funding Opportunities;Genetic;Genetic Research;Geography;Goals;Grant;Health;health disparity;health equity;Health Promotion;Home;Human Resources;improved;innovation;Institution;Intervention;Investigation;Knowledge;Koreans;Lead;Leadership;Logistics;Medical;Methods;metropolitan;Minority Health Research;Modeling;Molecular;multidisciplinary;Neighborhoods;Organizational Objectives;outreach;Participant;Performance;Phase;Pilot Projects;pilot test;population based;population health;Precision Health;Prevention;Process;Protocols documentation;Questionnaires;racial diversity;Randomized;Readiness;recruit;Research;Research Infrastructure;Research Methodology;Research Personnel;research study;Resources;response;Sampling;Science;Site;social;South Asian;southeast Asian;Subgroup;success;Surveys;Training;Underrepresented Minority;United States National Institutes of Health;Universities;Vietnamese;Work

PROJECT_TITLE: Chicago CCFC for the new AsA-NHPI cohort


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: SOCIAL SCIENCES

PHR: NARRATIVE/PUBLIC HEALTH RELEVANCE  This project will examine the influences of neighborhood built and social environments, acute individual and contextual precipitants, as well as demographics and social history, biobehavioral and psychosocial predispositions on physical activity (PA) adoption and maintenance among sedentary Pacific Islander adults in Utah. It will use emerging mobile health technologies to measure PA and its key correlates in real time in the real world. The study will fill key gaps in the literature on important correlates and mechanisms underlying PA behavioral change for this fast-growing, high health risk, yet severely understudied population group, and will provide critical information on how to improve their PA level and reduce obesity and obesity-related health problems. The methodology and findings derived from this study will also provide a new perspective in understanding PA behavior of other racial/ethnic groups with high obesity and low PA levels.

PI_NAMEs: WAN, NENG  (contact)

PROGRAM_OFFICER_NAME: BERRIGAN, DAVID

PROJECT_TERMS: Acute;Address;Adoption;Adult;advanced analytics;analytical tool;Area;Behavior;behavior change;Behavioral;behavioral study;biobehavior;built environment;Cardiovascular Diseases;Characteristics;Communities;contextual factors;Data;demographics;design;Diabetes Mellitus;disorder risk;Disparity;Ecological momentary assessment;Enrollment;Environment;Environmental Exposure;Environmental Risk Factor;ethnic minority;Ethnic Population;exercise intervention;experience;Frequencies;Geographic Information Systems;Geography;Goals;Health;health determinants;health disparity;Health Psychology;Health Technology;high risk population;Hour;improved;indexing;Individual;innovation;interest;Intervention;Link;Literature;Location;Longitudinal Studies;Maintenance;Malignant Neoplasms;Maps;Measurement;Measures;Mediating;member;Methodology;Methods;mHealth;Modeling;multidisciplinary;Nature;negative affect;neighborhood safety;Neighborhoods;Not Hispanic or Latino;novel;Obesity;Outcome;Pacific Islander;Participant;Pathway interactions;Patient Self-Report;Physical activity;Physiological;Policies;Population;Population Group;Poverty;predictive modeling;Predisposition;psychosocial;Psychosocial Factor;public health relevance;racial minority;racial population;Recommendation;Recording of previous events;Reduce health disparities;Research;Resources;Risk;sedentary;Self Efficacy;Site;social;social cognitive theory;social cohesion;Social Environment;Stress;System;Technology;Testing;Time;United States;Utah

PROJECT_TITLE: Using Momentary Measures to Understand Physical Activity Adoption and Maintenance among Pacific Islanders in the United States

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: LAY DESCRIPTION Brain inflammation play critical role in progression of the Alzheimer diseases. The purpose of this study is to highlight the factors and mechanisms regulating entrance and activity of the circulating neutrophils in the brain that aggravate inflammation in the Alzheimer diseases. This may provide a foundation for developing novel therapeutic strategies to prevent cognitive decline and ravages of Alzheimer disease.

PI_NAMEs: ANDJELKOVIC-ZOCHOWSKA, ANUSKA V. (contact);STAMATOVIC, SVETLANA M

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: 3xTg-AD mouse;Acute;Address;Adverse effects;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Amyloid beta-Protein Precursor;antagonist;Anti-Inflammatory Agents;Attenuated;Autoimmune Diseases;Automobile Driving;B-Lymphocytes;Behavioral;behavioral outcome;Blood;Blood Platelets;blood vessel occlusion;Blood Vessels;Brain;brain endothelial cell;brain parenchyma;Cell Respiration;Cells;Cerebral Amyloid Angiopathy;Cerebral endothelium;cerebrovascular;Cerebrovascular system;Chronic;Cognitive deficits;Complex;CXCL1 gene;cytokine;Data;defined contribution;Deposition;design;Development;Disease;Disease Progression;Elements;Encephalitis;Endothelium;Environmental Risk Factor;Event;extracellular;Extravasation;Foundations;Genes;Genetic;genetic manipulation;Hemostatic Agents;hyperphosphorylated tau;Immune;Immune response;Impaired cognition;improved;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Injury;Innate Immune Response;Invaded;Iron;junctional adhesion molecule;Knock-out;Knockout Mice;Learning;Leukocyte Adhesion Molecules;Leukocytes;Macrophage;Membrane;Memory;Memory Loss;Microglia;migration;Mitochondria;Modality;Molecular;monocyte;mouse model;Mus;Mutation;Nerve Degeneration;neurodegenerative dementia;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;neuron loss;neuropathology;neutrophil;Neutrophil Activation;Neutrophil Infiltration;novel therapeutic intervention;novel therapeutics;Oxidative Stress;pathogen;Pathogenesis;Pathologic;Pathology;Peptides;Peripheral;peripheral blood;Phenotype;Play;presenilin-1;prevent;Process;Proteins;Proteomics;recruit;Regulation;Role;Senile Plaques;Serum;Side;Synapses;System;tau Proteins;Testing;TFF1 gene;Tight Junctions;transcriptomics;Transgenic Organisms;treatment strategy;Vascular Diseases;vascular injury

PROJECT_TITLE: Deciphering the role of junctional adhesion molecule-A in neutrophil-driven inflammatory response in Alzheimer disease

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Aging;Neurodegenerative;Neurosciences

ORG_CITY: PISCATAWAY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative We discovered a previously unrecognized mechanism by which neurons protect against effects of protein aggregation and dysfunctional organelles—neurons physically throw out their threatening trash in large membrane-surrounded vesicles (exophers) for uptake and degradation by remote cells. We propose that exopher production constitutes a conserved pathway for maintaining neuronal health and we speculate that, with age or excess stress, the exopher pathway inappropriately contributes to neurodegeneration and spread of neurotoxic species. Our planned study of molecular factors that act in, and modulate, exopher formation in an accessible animal model may identify novel targets for future therapeutic benefit in neurodegenerative disease.

PI_NAMEs: DRISCOLL, MONICA A. (contact);GRANT, BARTH DEMIAN

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Actins;Actomyosin;Acute;Address;Adult;Age;aging brain;aging population;Alzheimer's Disease;Animal Model;Animals;Area;Articulation;Autophagocytosis;Basic Science;Biological;Biology;Brain;Brain Diseases;brain health;Caenorhabditis elegans;Cardiac Myocytes;Cell Physiology;Cells;Cellular biology;clinical development;Collection;Complex;Cytokinesis;Cytoskeletal Proteins;Cytoskeleton;Data;Disease;Dissection;driving force;Event;extracellular;Foundations;Future;Genetic;genetic manipulation;Goals;Growth;Hand;Health;healthy aging;Human;human disease;Huntington Disease;Image;in vivo;in vivo imaging;Individual;Induced Neurons;insight;Intervention;Kinesis;Knowledge;life span;Lipids;mature animal;Measures;Mediating;Membrane;Methods;Microtubule-Organizing Center;Microtubules;Modeling;Molecular;Molecular Chaperones;Molecular Genetics;Movement;multicatalytic endopeptidase complex;Mus;Muscle;Nanotubes;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;neuronal cell body;Neurons;neuroprotection;Neurosciences;neurotoxic;novel;Organelles;Organism;overexpression;Pathogenesis;Pathology;Pathway interactions;permissiveness;polyglutamine;Process;Production;protein aggregation;protein degradation;Proteins;proteostasis;proteotoxicity;Quality Control;Reporting;Role;Route;segregation;Stress;System;Testing;Therapeutic;Therapeutic Intervention;tool;Toxin;uptake;Vesicle;Visualization;Work

PROJECT_TITLE: Molecular and Cell Biological Foundations of Proteostress-Induced Neuronal Extrusion

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]