NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention

ORG_CITY: CARY

ORG_NAME: ALLUCENT GOVERNMENT SERVICES (US) LLC

PI_NAMEs: BRUCE, MCCLENATHAN  (contact)

PROJECT_TERMS: clinical trial implementation;Clinical Trials;Clinical Trials Unit;Communicable Diseases;early phase clinical trial;Influenza Therapeutic;Intervention;Investigation;New Agents;Phase I Clinical Trials;Prevention

PROJECT_TITLE: Task C1: Phase I Clinical Trial to Evaluate Influenza Therapeutics


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: LOGAN

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UTAH STATE UNIVERSITY

ORG_STATE: UT

PI_NAMEs: HURST, BRETT  (contact)

PROJECT_TERMS: Advanced Development;Anti-viral Agents;antimicrobial;Biological Assay;Cell Line;Contracts;Development;Human;In Vitro;in vitro testing;Maintenance;Respiratory syncytial virus;respiratory virus;Rhinovirus;therapeutic development;Viral;Virus

PROJECT_TITLE: Task B25: In Vitro Assessment for Antimicrobial Activity Against Respiratory Viruses


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

PROJECT_TERMS: 2019-nCoV;Advanced Development;Anti-viral Agents;antimicrobial;Biological Assay;Cell Line;Contracts;Development;In Vitro;in vitro testing;Influenza Therapeutic;Maintenance;Middle East Respiratory Syndrome Coronavirus;respiratory virus;SARS coronavirus;Viral;Virus

PROJECT_TITLE: Task B25: In Vitro Assessment for Antimicrobial Activity Against Respiratory Viruses, SARS-CoV-2


PROJECT_TERMS: Advanced Development;Anti-viral Agents;antimicrobial;Biological Assay;Cell Line;Contracts;Development;Human;In Vitro;in vitro testing;Maintenance;Respiratory syncytial virus;respiratory virus;therapeutic development;Viral;Virus

PROJECT_TITLE: Task B19: In Vitro Assessment for Antimicrobial Activity Against Respiratory Viruses


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: HORSHAM

ORG_NAME: NATIONAL MEDICAL SERVICES, INC.

ORG_STATE: PA

PI_NAMEs: KENDRICK, KRISTIN  (contact)

PROJECT_TERMS: Autopsy;Biological Assay;Blood;Blood specimen;Brain;brain tissue;Cost Savings;Databases;drug of abuse;Ensure;Government;Human;National Institute of Mental Health;Neurosciences Research;Pharmaceutical Preparations;Pharmacologic Substance;Research;Research Personnel;Sampling;screening;Secure;Site;Specimen;Test Result;Testing;testing services;Therapeutic;Tissue Sample;Tissues;Toxic Environmental Substances;Toxicology;United States National Institutes of Health;Vendor

PROJECT_TITLE: TO PROVIDE THE NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH) WITH NBB TISSUE TOXICOLOGY TESTING SERVICES


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Methamphetamine;Neurosciences;Patient Safety;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: WILMINGTON

ORG_NAME: PPD DEVELOPMENT LP

ORG_STATE: NC

PI_NAMEs: PEROUTKA, STEPHEN  (contact)

PROJECT_TERMS: Academia;Basic Science;Biotechnology;Chemistry;Clinic;clinical candidate;Clinical Protocols;Clinical Trials;Contractor;Data;Development;Dose;Double-Blind Method;drug development;drug discovery;Drug Formulations;Drug Kinetics;Elements;experience;Funding;Goals;Grant;Human;Institution;Intellectual Property;Lead;Licensing;manufacture;Methamphetamine use disorder;Nervous System;Nervous System Disorder;Neurosciences Research;novel;novel therapeutics;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;phase I trial;placebo controlled study;programs;Property Rights;Protocols documentation;Randomized;Research;research clinical testing;Research Design;Research Personnel;Research Support;Risk;safety assessment;small molecule;success;Testing;Toxicology;Translating;United States National Institutes of Health

PROJECT_TITLE: PHASE I RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED STUDY TO ASSESS SAFETY, TOLERABILITY, AND PHARMACOKINETICS


ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PI_NAMEs: BLOUGH, BRUCE  (contact)

PROJECT_TERMS: Biological;Chemistry;Communicable Diseases;Development;Development Plans;Drug Kinetics;Evaluation;In Vitro;in vivo;Interventional Agent Development;Lead;manufacture;pathogen;pre-clinical;product development;programs;Safety;scale up;Services;Therapeutic;therapeutic development;Toxicology;Toxin

PROJECT_TITLE: Task B30: Scale Up Synthesis of VKT-034


ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

ORG_STATE: CA

PI_NAMEs: MIRASILAS, JON  (contact)

PROJECT_TERMS: Biological;Chemistry;Communicable Diseases;Development;Development Plans;Drug Kinetics;Evaluation;In Vitro;in vivo;Interventional Agent Development;Lead;manufacture;pathogen;pre-clinical;product development;programs;Safety;Services;Therapeutic;therapeutic development;Toxicology;Toxin

PROJECT_TITLE: Task D17: Non-Clinical Services for Development of Interventional Agents for Infectious Diseases


PI_NAMEs: MIRSALIS, JON  (contact)

PROJECT_TITLE: Task D18: Non-Clinical Services for Development of Interventional Agents for Infectious Diseases


ORG_CITY: SAINT CHARLES

ORG_NAME: EUROFINS PANLABS, INC.

ORG_STATE: MO

PI_NAMEs: BODE, JACOB  (contact)

PROJECT_TERMS: Biological;Biological Assay;Chemistry;Communicable Diseases;Development;Development Plans;Drug Kinetics;Evaluation;In Vitro;in vivo;Interventional Agent Development;Lead;lead optimization;manufacture;pathogen;pre-clinical;product development;programs;Property;Rodent;Safety;screening;Services;Therapeutic;therapeutic development;Toxicology;Toxin

PROJECT_TITLE: Task E14: Lead Optimization Screening Assays for ADMET, Safety Profiling, Rodent Pharmacokinetics and MTD


PROJECT_TITLE: Task D16: Non-Clinical Services for Development of Interventional Agents for Infectious Diseases


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR/STTR CONTRACTS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

ORG_CITY: IRVING

ORG_NAME: PIECES TECHNOLOGIES, INC.

ORG_STATE: TX

PI_NAMEs: AMARASINGHAM, RUBEN  (contact)

PROJECT_TERMS: Artificial Intelligence;Cancer Center;Cancer Patient;cancer therapy;Caring;Categories;chatbot;Client;Client satisfaction;Clinical;Clinical Trials;Community Services;Data;Data Analyses;data streams;Databases;design;Development;effectiveness measure;electronic health record system;Environment;Ethics;Evaluation;Feedback;improved;improved outcome;Inpatients;Institutional Review Boards;intelligent agent;Intervention;Measures;Methods;Notification;Oncology;Outcome;Outpatients;Output;patient population;Patient Recruitments;Patients;Performance;Phase;Play;Process;Prognosis;programs;Protocols documentation;Questionnaires;Reporting;Research;response;responsible artificial intelligence;Role;screening;Screening procedure;Site;Small Business Innovation Research Grant;social health determinants;Surveys;System;Testing;tool

PROJECT_TITLE: FY24 SBIR PHASE IITOPIC NO. 423 PROJECT TITLE: "PASSIVE AND ACTIVE AI SCREENING FOR SOCIAL DETERMINANTS OF HEALTH AND INTERVENTIONS TO IMPROVE OUTCOMES IN THE CANCER PATIENT POPULATION".


ORG_CITY: LUTZ

ORG_STATE: FL

PI_NAMEs: LI, BORUI  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;acoustic imaging;Address;Adoption;Algorithms;Amplifiers;Cancer Center;Clinical;Controlled Environment;cost effective;data acquisition;Deposition;design;Development;Devices;Dose;Dose Rate;dosimetry;Electrons;Elements;Emerging Technologies;Environment;Evaluation;experimental study;Film;Goals;Image;image reconstruction;Imaging technology;instrument;invention;Ionizing radiation;Maps;Measures;Methods;Michigan;Modeling;Monitor;Motor;Noise;Performance;performance tests;Physiologic pulse;Polychlorinated Biphenyls;Positioning Attribute;prototype;quality assurance;Radiation;Radiation Dose Unit;Radiation therapy;reconstruction;Research;Resolution;Speed;Structure;System;Systems Development;Time;tool;Transducers;Universities;Work

PROJECT_TITLE: TOPIC #461 DEVELOPMENT OF A FLASH DOSIMETRY SYSTEM BASED ON IONIZING RADIATION ACOUSTIC IMAGING


NIH_SPENDING_CATS: Cancer;Radiation Oncology

ORG_CITY: Santa Clara

ORG_NAME: TIBARAY, INC.

PI_NAMEs: TOUFEXIS, FILIPPOS  (contact)

PROJECT_TERMS: Academic Medical Centers;Behavior;cancer care;Charge;Clinical;clinical implementation;Contracts;design;Documentation;Dose;Dose Rate;Electrons;Feedback;Goals;Human;Image;interest;Letters;Linear Accelerator Radiotherapy Systems;manufacture;Measures;millisecond;Monitor;Performance;Phase;Photons;Physiologic pulse;pre-clinical;programs;Protons;prototype;Radiation Oncology;Radiation therapy;real time monitoring;Reproducibility;Research;Roentgen Rays;Small Business Innovation Research Grant;System;Testing;Time;Universities;Update;usability;Vendor

PROJECT_TITLE: FY24 SBIR PHASE IITOPIC NO. 434PROJECT TITLE:  ULTRA-RAID RF-BASED BEAM MONITOR FOR REAL-TIME FLASH BEAM CONTROL


ACTIVITY: ZIA

ADMINISTERING_IC: HG

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: GAHL, WILLIAM  (contact)

PROJECT_TERMS: absorption;Academy;Achievement;Advocacy;Albinism;Alkaptonuria;Alleles;Arterial calcification due to deficiency of CD73;arthropathies;authority;Award;Bacterial Infections;base;Basic Science;Biochemical;Biochemical Genetics;Biochemical Pathway;Biochemistry;Biological;Biological Sciences;bisphosphonate;Bleeding time procedure;Blood Platelets;Bone Diseases;Brazil;Caring;Catabolism;Cells;Cellular Assay;Cellular biology;chediak-higashi syndrome;CHS1 gene;Clinical;Clinical Protocols;Clinical Research;Clinical Trials;cohort;Collaborations;Communities;Congenital disorders of glycosylation;Congo;Cooperative Research and Development Agreement;Country;Cysteamine;Cystine;Cystinosis;Cytoplasmic Granules;cytotoxic;Data;Defect;Developing Countries;Diagnosis;Diagnostic;Disease;Doctor of Philosophy;Eating;Endocannabinoids;Enrollment;Enzymes;Exocytosis;Focal and Segmental Glomerulosclerosis;Food and Drug Administration Drug Approval;Formulation;Fostering;Foundations;Freeze Drying;Future;gene therapy;Genes;Genetic;Genetic Diseases;Genetic study;genetic testing;Genome;Genotype;Ghana;Glutamate Receptor;Glycoproteins;Goals;Hemorrhage;Hemostatic Agents;Hermanski-Pudlak Syndrome;Histiocytosis;Homogentisic Acid;Human;human disease;Human Genome;Human Resources;Impairment;India;Individual;Inhalation;inhibitor;insight;interest;International;international center;Intervention Studies;Kidney Failure;Knock-in Mouse;Lead;Leadership;Lymphocyte;Lysosomal Storage Diseases;Lysosomes;Mali;Manuscripts;Measures;Medical;meetings;member;Methods;Modeling;Molecular;Molecular Diagnosis;mouse model;Mutation;Myopathy;N-acetylmannosamine;National Center for Advancing Translational Sciences;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Neurological Disorders and Stroke;National Institute on Alcohol Abuse and Alcoholism;Natural History;Nature;neglect;nephropathic cystinosis;Neurologic;Neurology;Neuromuscular Diseases;Neurons;New Drug Approvals;New York;NOS2A gene;novel;Oculocutaneous Albinism;Oral;Outcome Measure;Pakistan;participant enrollment;Patient Care;patient derived induced pluripotent stem cells;Patients;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;Physicians;Plasma;Play;Principal Investigator;Production;Prognosis;programs;Property;protein function;Proteinuria;Protocols documentation;Publishing;Pulmonary Fibrosis;randomized placebo controlled study;Rare Diseases;receptor;Reporting;Research;Research Personnel;Research Project Grants;research study;Role;Rome;safety testing;Science;Scientist;Services;Sialic Acids;Specimen;Study Section;Surveys;symposium;T-Lymphocyte;Testing;Time;translational research program;Tyrosine;United States National Institutes of Health;Update;Variant;Vascular calcification;Vesicle;virtual;Work;Writing

PROJECT_TITLE: Human Biochemical Genetics


ACTIVITY: ZIC

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: OFFICE OF THE DIRECTOR, NCI

PI_NAMEs: KOMSCHLIES MCCONVILLE, KRISTIN  (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;animal facility;Animals;Biomedical Research;cancer care;Cancer Etiology;cancer therapy;Clinical;commercialization;Communities;Congresses;cost;Development;Diagnostic tests;Disease;evidence base;flexibility;Funding;Goals;Government;health care delivery;Healthcare;Home;improved;Investments;Laboratories;Laboratory Research;Lead;Malignant Neoplasms;meetings;Nanotechnology;New Drug Approvals;nonhuman primate;novel diagnostics;Patients;Persons;Pharmaceutical Preparations;Private Sector;programs;prototype;public-private partnership;Research;research and development;Research Personnel;response;Scientist;Services;Speed;Technology;technology development;Time;Translations;Universities;vaccine evaluation;Vaccines;Washington

PROJECT_TITLE: NCI-Frederick Support and Technical Services


ACTIVITY: ZIH

NIH_SPENDING_CATS: Bioengineering;Cancer;Data Science;HIV/AIDS;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SHILLING, JEFFREY  (contact)

PROJECT_TERMS: Area;artificial intelligence method;Clinical;Clinical Data;Collaborations;Complement 3d;computing resources;cost efficient;Data;Data Aggregation;Data Analyses;data and analysis portal;data exchange;Data Files;data integration;data interoperability;data management;data resource;data sharing;Data Storage and Retrieval;Development;digital pathology;Dimensions;Ensure;Environment;Fostering;Foundations;Genomics;Histopathology;Image;Image Analysis;Licensing;Medical Records;metabolomics;Metadata;microbiome;Modeling;Modernization;multimodality;National Center for Advancing Translational Sciences;Participant;Process;Production;programs;Proteomics;Research;Resources;Scanning;scientific computing;Secure;Site;Slide;Software Engineering;System;Systems Analysis;United States National Institutes of Health

PROJECT_TITLE: NCI Central Scientific Computing Resources


ACTIVITY: ZII

NIH_SPENDING_CATS: Cancer;HIV/AIDS

PI_NAMEs: KHOSHBIN, JEAN-PATRICE  (contact)

PROJECT_TERMS: Area;Contractor;Contracts;cost;cost effective;design;Emergency Situation;Grant;innovation;Mission;Monitor;National Cancer Institute;operation;Process;programs;Property;Services;symposium;United States National Institutes of Health

PROJECT_TITLE: Space and Facilities Management


NIH_SPENDING_CATS: Cancer;Immunotherapy

PROJECT_TERMS: Air Pressure;Cell Therapy;Cells;Cellular immunotherapy;Cyclic GMP;design;Guidelines;Human;human subject;Industry;Infrastructure;Infusion procedures;manufacture;Manufacturer;participant enrollment;Patients;Pharmaceutical Preparations;Phase;Primary Cell Cultures;Primary Neoplasm;Sterility;Tissues;Tumor Expansion;Tumor-Infiltrating Lymphocytes;United States National Institutes of Health

PROJECT_TITLE: TIL Rosenberg Modular Processing Facility (T30 building)


ACTIVITY: ZIK

PI_NAMEs: FRISBIE, SUZANNE  (contact)

PROJECT_TERMS: Academia;Agreement;Biotechnology;Client;Clinical Research;Clinical Trials;Collaborations;Commercial Sectors;Confidential Information;Contracts;Cooperative Research and Development Agreement;Data;data exchange;Development;Devices;Disclosure;Employee;Extramural Activities;Industry;Intellectual Property;invention;Laboratories;Laws;Legal patent;Licensing;Marketing;material transfer agreement;Mediation;meetings;Monitor;National Cancer Institute;New Agents;Nonprofit Organizations;Pharmacologic Substance;Policies;Procedures;programs;Recommendation;Regulation;Reporting;Research;research and development;Research Personnel;Research Support;Resources;Safety;Services;symposium;Technology;technology development;Technology Transfer;Transact;Transfer Agreement;United States National Institutes of Health;Universities

PROJECT_TITLE: Technology Transfer Center


ORG_CITY: ROCKVILLE

ORG_NAME: FISHER BIOSERVICES, INC.

ORG_STATE: MD

PI_NAMEs: EYLER, DENNIS  (contact)

PROJECT_TERMS: Adherence;Clinical;clinical material;Clinical Research;Clinical Trials;Communicable Diseases;Contracts;Ensure;Good Clinical Practice;good laboratory practice;Good Manufacturing Process;Microbiology;programs;Services;Shipping;Specimen

PROJECT_TITLE: Division of Microbiology and Infectious Diseases (DMID): Clinical Materials Services (CMS)


PROJECT_TERMS: Adherence;Clinical;clinical material;Clinical Research;Clinical Trials;Communicable Diseases;Contracts;Ensure;Good Clinical Practice;good laboratory practice;Good Manufacturing Process;Microbiology;Monkeypox;programs;Services;Shipping;Specimen

PROJECT_TITLE: Division of Microbiology and Infectious Diseases (DMID): Clinical Materials Services (CMS): mpox Studies


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: STERLING

ORG_NAME: RESOURCEPATH, LLC

ORG_STATE: VA

PI_NAMEs: HILL, DANA ASHLEY  (contact)

PROJECT_TERMS: 2019-nCoV;Biological Assay;COVID-19 diagnostic;Development;diagnostic development;Human;Infectious Agent;product development;Services

PROJECT_TITLE: Development of SARS-CoV-2 Diagnostics


ORG_CITY: BETHESDA

ORG_NAME: TECHNICAL RESOURCES INTERNATIONAL, INC.

PI_NAMEs: ELLIS, JESSICA  (contact)

PROJECT_TERMS: Clinical Research;clinical research site;Clinical Trials;Data;Monitor;Operations Research;programs;Research Personnel;Resources;Safety;Services;Site;Training

PROJECT_TITLE: DMID Clinical Research Operations & Management Support (CROMS)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: DESSAU-ROSSLAU

ORG_COUNTRY: GERMANY

ORG_FIPS: GM

ORG_NAME: IDT BIOLOGIKA GMBH

PI_NAMEs: TRUSHEIM, HEIDI  (contact)

PROJECT_TERMS: Adjuvant;Biological Products;cell bank;Clinical Research;Communicable Diseases;Contracts;COVID-19 vaccine;Cyclic GMP;Development;Development Plans;manufacture;next generation;novel vaccines;Phase;product development;Services;System;United States Food and Drug Administration;vaccine delivery;vaccine development;Vaccines

PROJECT_TITLE: Task V34: Master Cell Banks Manufacturing for Next Generation SARS-CoV-2 Vaccines


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PI_NAMEs: FOUTS, TIM  (contact)

PROJECT_TERMS: Adjuvant;Bacterial Drug Resistance;Biological Products;Candida auris;Clinical Research;Communicable Diseases;Contracts;Cyclic GMP;Development;Development Plans;fungus;manufacture;novel vaccines;pathogen;Phase;Process;product development;Services;System;United States Food and Drug Administration;vaccine delivery;vaccine development;Vaccines

PROJECT_TITLE: Task V31: Process Development for Panfungal Vaccine


ORG_CITY: COLUMBUS

ORG_NAME: BATTELLE CENTERS/PUB HLTH RES & EVALUATN

ORG_STATE: OH

PI_NAMEs: RUDGE, THOMAS  (contact)

PROJECT_TERMS: Area;Biological;Biological Products;Bioterrorism;Clinical;Communicable Diseases;Contracts;COVID-19 testing;COVID-19 vaccine;Development;Educational workshop;efficacy testing;Emerging Communicable Diseases;evaluation/testing;Feasibility Studies;immunogenicity;Immunology procedure;Investigational New Drug Application;Licensing;novel vaccines;Office of Administrative Management;product development;Qualifying;Reporting;Safety;Sampling;Services;Site Visit;Testing;testing services;Toxicity Tests;Toxicology;Training;vaccine candidate;vaccine development;Vaccines;Validation

PROJECT_TITLE: Task V11: General Safety Toxicity Testing, SARS-CoV-2


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PROJECT_TERMS: Area;Biological;Biological Products;Bioterrorism;Clinical;Communicable Diseases;Contracts;Development;Educational workshop;efficacy testing;Emerging Communicable Diseases;evaluation/testing;Feasibility Studies;immunogenicity;Immunology procedure;Investigational New Drug Application;Licensing;novel vaccines;Office of Administrative Management;product development;Qualifying;Reporting;Safety;Sampling;Services;Site Visit;Testing;testing services;Toxicity Tests;Toxicology;Training;vaccine candidate;vaccine development;Vaccines;Validation

PROJECT_TITLE: Task V11: General Safety Toxicity Testing


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Orthopoxviruses;Prevention;Rare Diseases;Vaccine Related

PROJECT_TERMS: Area;assay development;Biological;Biological Products;Bioterrorism;Clinical;Communicable Diseases;Contracts;Development;Educational workshop;efficacy testing;Emerging Communicable Diseases;evaluation/testing;Feasibility Studies;immunogenicity;Immunology procedure;Investigational New Drug Application;Licensing;Monkeypox;novel vaccines;Office of Administrative Management;product development;Qualifying;Reagent;Reporting;Safety;Sampling;Services;Site Visit;Testing;testing services;Toxicology;Training;vaccine candidate;vaccine development;Vaccines;Validation

PROJECT_TITLE: Task V15: Development of Assays and Reagents for mpox Vaccines


PROJECT_TERMS: Area;Biological;Biological Products;Bioterrorism;Clinical;Communicable Diseases;Contracts;COVID-19 vaccine;Development;Educational workshop;efficacy testing;Emerging Communicable Diseases;evaluation/testing;Feasibility Studies;Hamsters;immunogenicity;Immunology procedure;Investigational New Drug Application;Licensing;Modeling;novel vaccines;Office of Administrative Management;product development;Qualifying;Reporting;Safety;Sampling;Sarbecovirus;Services;Site Visit;Testing;testing services;Toxicology;Training;vaccine candidate;vaccine development;vaccine evaluation;Vaccines;Validation

PROJECT_TITLE: Task V20: Hamster Sarbecovirus Challenge Model for SARS-CoV-2 Vaccine Testing


NIH_SPENDING_CATS: Infectious Diseases;Patient Safety;Sexually Transmitted Infections

ORG_CITY: COLUMBIA

ORG_NAME: ADVARRA, INC.

PI_NAMEs: ATKINSON, REBECCA  (contact)

PROJECT_TERMS: Bacteria;Clinical Trials;Communicable Diseases;Institutional Review Boards;National Institute of Allergy and Infectious Disease;Services;Site;Treponema pallidum subspecies pallidum

PROJECT_TITLE: Single Institutional Review Board (sIRB)


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: WASHINGTON

ORG_STATE: DC

PROJECT_TERMS: Code;design;design and construction;Development;Engineering;Ensure;Extramural Activities;Funding;Grant Review;Mission;Phase;Process;programs;Published Comment;Qualifying;Regulation;research facility;Research Infrastructure;Resolution;Resources;Technical Expertise;United States National Institutes of Health

PROJECT_TITLE: FY24 GRANT REVIEWS PERFORMED BY DTR


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Nanotechnology;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PI_NAMEs: LEVY, OFER  (contact)

PROJECT_TERMS: Adjuvant;Adjuvanticity;Adult;aluminum sulfate;aqueous;Blood;Cells;Contractor;Elderly;Evaluation;Formulation;Human;Immunity;Immunization;in silico;in vivo;influenza virus vaccine;Investigation;Lead;Libraries;Liposomes;Mononuclear;nanoparticle;Newborn Infant;novel;Peripheral Blood Mononuclear Cell;Pharmaceutical Chemistry;Preparation;programs;receptor;Route;screening;Signal Pathway;Sister;small molecule;small molecule libraries;System;T cell response;Vaccine Adjuvant;vaccinology

PROJECT_TITLE: VACCINE ADJUVANT DISCOVERY PROGRAM (VADP)


NIH_SPENDING_CATS: Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Natural Products;Rare Diseases;Tuberculosis

ORG_CITY: PLAN-LES-OUATES

ORG_COUNTRY: SWITZERLAND

ORG_FIPS: SZ

ORG_NAME: VACCINE FORMULATION INSTITUTE (CH) LTD

PROJECT_TERMS: Adjuvant;Adjuvanticity;Agonist;Animal Model;Benchmarking;C-Type Lectins;Cell Line;Cells;Chemicals;Contractor;design;Formulation;Human;Immunologic Adjuvants;In Vitro;Inflammasome;Knockout Mice;Lead;lead candidate;Libraries;Macrophage;Mycobacterium tuberculosis;Natural Products;novel;Pathway interactions;Peripheral Blood Mononuclear Cell;Pre-Clinical Model;receptor;Reporter;scaffold;screening;Specificity;Structure-Activity Relationship;synergism;Testing

PROJECT_TITLE: Synthetic Macrophage-inducible C-type lectin (Mincle) Agonists: Screening, Design, and Formulation in combination Th17 adjuvants


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Immunotherapy;Infectious Diseases;Nanotechnology;Vaccine Related

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PI_NAMEs: CARSON, DENNIS  (contact)

PROJECT_TERMS: 2019-nCoV;Adjuvant;analog;Antigen-Presenting Cells;Antigens;Biochemical;Biological Assay;Cell Survival;Cells;COVID-19 vaccine;cytotoxicity;design;Dose;Formulation;Genetic;high throughput screening;Human;Immune;immune activation;Immunology procedure;innate immune pathways;Intramuscular;Lead;lipid nanoparticle;Messenger RNA;Modeling;Molecular;Molecular Weight;mouse model;Mus;novel;preclinical study;Preparation;protective efficacy;Protein Biosynthesis;Proteins;RNA vaccine;Safety;scaffold;scale up;Structure-Activity Relationship;Transfection;vaccine formulation;Work

PROJECT_TITLE: Discovery of Adjuvants for mRNA Vaccines


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Orphan Drug;Pneumonia and Influenza;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PI_NAMEs: ESSER-KAHN, AARON  (contact)

PROJECT_TERMS: Adjuvant;Agonist;Antibodies;Cells;Contractor;cytokine;Derivation procedure;drug-like compound;Formulation;Goals;Ha antigen;Immune;improved;In Vitro;in vivo;in vivo evaluation;Influenza vaccination;influenza virus vaccine;Innate Immune Response;Libraries;Modeling;Molecular;mouse model;novel;Pathway interactions;Phenotype;predicting response;Property;Proteins;response;RNA vaccination;RNA vaccine;Safety;screening;Signal Pathway;System;T-Lymphocyte;Tuberculosis;Vaccination;Vaccines

PROJECT_TITLE: Discovery of Adjuvants that Direct T-cell Fates for Improved Safety and Efficacy in  Vaccines Against Influenza and Tuberculosis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related;Valley Fever

ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PI_NAMEs: EVANS, JAY  (contact)

PROJECT_TERMS: Adjuvant;age related;Agonist;Antigens;Cells;Coccidioidomycosis;Contractor;efficacy study;Formulation;Human;Immune;Immunity;Lead;lead candidate;Libraries;Ligands;Mediating;Modeling;Mus;Mycobacterium tuberculosis;novel;pathogenic bacteria;pathogenic fungus;Phenotype;Preclinical Testing;screening;Testing;Vaccine Adjuvant

PROJECT_TITLE: Identification of Novel Syk/Raf-1 Mediated CLR Ligands as Vaccine Adjuvants


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

PI_NAMEs: CHANG, POLLY YEE (contact)

PROJECT_TERMS: Academia;Acute;Advanced Development;Contracts;Development;dosimetry;drug development;Foundations;Funding;Government;Government Agencies;Industry;Licensure;Medical center;medical countermeasure;National Institute of Allergy and Infectious Disease;Nuclear;nuclear countermeasure;Pathway interactions;product development;Radiation;Radiation exposure;Radiation Toxicity;Radioisotopes;research and development;Research Support;screening;Testing;Work

PROJECT_TITLE: Radiation/Nuclear Medical Countermeasure (MCM) Product Development Support


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases

ORG_CITY: LAKE CLEAR

ORG_STATE: NY

PROJECT_TERMS: Address;Antibodies;Award;Binding;Biological Assay;Biotinylation;Cells;Communities;Contractor;cross reactivity;cytokine;Enzyme-Linked Immunosorbent Assay;Ferrets;Fluorochrome;Hamsters;Human;Immune;Immune response;Immunity;infectious disease model;Label;manufacturing scale-up;Memory;Modification;Monoclonal Antibodies;Mus;Pathogenesis;Phase;Reagent;Respiratory Tract Infections;Small Business Innovation Research Grant;Tissues;vaccine efficacy;Validation

PROJECT_TITLE: Further characterization and validation of monoclonal antibodies to study respiratory infections in the ferret


NIH_SPENDING_CATS: Infectious Diseases;Sexually Transmitted Infections

ORG_NAME: TETRACORE, INC.

PI_NAMEs: COCKRELL, LISA  (contact)

PROJECT_TERMS: Biological Assay;Development;diagnostic development;Molecular;point-of-care detection;Small Business Innovation Research Grant;Treponema pallidum

PROJECT_TITLE: SBIR Topic 108: Development of Rapid Molecular Assay for Point of Care Detection of Treponema Pallidum


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NEWTON CENTER

ORG_NAME: CURE SYSTEMS LLC

PI_NAMEs: MILLER, JACQUELINE  (contact)

PROJECT_TERMS: Basic Science;combat;Development;Intervention;Malaria;Mediating;Monoclonal Antibodies;Small Business Innovation Research Grant

PROJECT_TITLE: SBIR Topic 109: Development of Monoclonal Antibody- Mediated Interventions to Combat Malaria


NIH_SPENDING_CATS: Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: MONROVIA

ORG_NAME: CHROMOLOGIC, LLC

PI_NAMEs: JIMENZ, JORGE  (contact)

PROJECT_TERMS: alternative treatment;Benzathine Penicillin;Small Business Innovation Research Grant;Syphilis;therapeutic development

PROJECT_TITLE: SBIR Topic 134: Alternatives to Benzathine Penicillin for Treatment of Syphilis


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: IRVINE

ORG_NAME: VULCAN BIOLOGICS, INC.

PI_NAMEs: GREEN, BRIAN  (contact)

PROJECT_TERMS: Antibiotic Resistance;Antibiotics;Bacteriophages;Biological Assay;design;Development;Disease;Genus Mycobacterium;Immune response;mycobacterial;Mycobacterium Infections;non-tuberculous mycobacterial infection;Phase;pre-clinical;pre-clinical research;preclinical development;Property;Resistance;Route;Small Business Innovation Research Grant;Technology;Therapeutic;therapeutic development;Variant

PROJECT_TITLE: SBIR Topic 131: Development of Bacteriophage for Treatment of Mycobacterial Infections


ORG_CITY: HUNTSVILLE

ORG_NAME: CFD RESEARCH CORPORATION

ORG_STATE: AL

PI_NAMEs: BHATT, KETAN  (contact)


ORG_CITY: MIAMI

ORG_NAME: TOLKA.AI INC

PI_NAMEs: WIKSTROM, JOHAN  (contact)


ORG_CITY: Framingham

ORG_NAME: KEPHERA DIAGNOSTICS, LLC

PI_NAMEs: LEVIN, ANDREW  (contact)

PROJECT_TERMS: Detection;Development;diagnostic development;Herpesvirus 1;Human Herpesvirus 2;Infection;Serology test;Small Business Innovation Research Grant

PROJECT_TITLE: SBIR Topic 133: Development of a Serological Test for Herpes Simplex Types 1 and 2 Infections


ORG_CITY: Carlsbad

ORG_NAME: QOOLABS, INC.

PI_NAMEs: QI, HONG  (contact)


ORG_NAME: IMMPORT THERAPEUTICS, INC.

PI_NAMEs: CAMERINI, DAVID  (contact)


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: KOELLE, DAVID  (contact)

PROJECT_TERMS: Alleles;Biological Assay;Blood;CD8-Positive T-Lymphocytes;Cell Line;Cells;Chlamydia trachomatis;cohort;Complex;Contracts;Cytoprotection;Dose;Epitopes;Herpesvirus 1;Human;Human Herpesvirus 2;Immune;Knowledge;Length;Libraries;Link;microbial;pathogen;Patients;Peptides;Proteins;Reporter;Research;response;Severity of illness;Sexually Transmitted Diseases;Simplexvirus;Syphilis;T-Lymphocyte;T-Lymphocyte Epitopes;Tissues;Treponema pallidum;Validation

PROJECT_TITLE: Large-Scale T Cell Immune Epitope Discovery and Mechanisms of T Cell Protection


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PI_NAMEs: FABRITZKY, BRANDON  (contact)

PROJECT_TERMS: Address;Antigens;Arenavirus;Binding;Chikungunya virus;Contracts;Coronavirus;Dengue Virus;Epitopes;Family;Family Picornaviridae;Flaviviridae;Human poliovirus;Immunize;immunogenic;Lassa;Measles;National Institute of Allergy and Infectious Disease;pandemic potential;pandemic preparedness;Paramyxovirus;Pathogenesis;pathogenic virus;prototype;T-Lymphocyte;Togaviridae;Vaccines;Validation;Viral;Virus;Virus Diseases;volunteer

PROJECT_TITLE: THE IDENTIFICATION AND VALIDATION OF EPITOPES CONSERVED IN VIRAL PATHOGEN FAMILIES WITH PANDEMIC POTENTIAL


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

PI_NAMEs: PETERS, BJOERN  (contact)

PROJECT_TERMS: Adult;Antigens;Bacteria;Binding;Bioinformatics;Biological Assay;cohort;Common Epitope;Communities;community acquired pneumonia;Contractor;Contracts;Custom;Diagnosis;Epitopes;Ethnic Origin;Flow Cytometry;Geography;Haemophilus influenzae;Immunity;Individual;Infection;Morbidity - disease rate;mortality;Mycoplasma pneumoniae;pathogen;pathogenic bacteria;patient screening;Patients;Peptides;Persons;Phenotype;Pneumonia;response;Selection Criteria;single cell sequencing;Sri Lanka;Staphylococcus aureus;Streptococcus pneumoniae;T cell response;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Epitopes;transmission process

PROJECT_TITLE: IDENTIFICATION AND CHARACTERIZATION OF T CELL EPITOPES FROM BACTERIAL PATHOGENS CAUSING PNEUMONIA


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PI_NAMEs: STERN, LAWRENCE  (contact)

PROJECT_TERMS: Affect;Antigens;Autoimmune Diseases;Autoimmunity;autoinflammatory diseases;autoreactive T cell;CD8-Positive T-Lymphocytes;Cell Physiology;Clinical;Contractor;cross reactivity;diagnostic value;Disease;Endogenous Retroviruses;Environment;Epitopes;Lead;Libraries;Mass Spectrum Analysis;Memory;MHC binding peptide;novel;Organ;Pathogenesis;Pathogenicity;Proteins;receptor;Regulatory T-Lymphocyte;Research;Role;screening;single cell sequencing;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Epitopes;Tissues;tool

PROJECT_TITLE: CD4 AND CD8 T CELL EPITOPES RECOGNIZED IN AUTOIMMUNE AND AUTOINFLAMMATORY DISEASES


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: OLD WESTBURY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NEW YORK INST OF TECHNOLOGY

PHR: PROJECT NARRATIVE The cellular processes at play during adipocyte hypertrophy (cellular enlargement) remain largely unknown which limits the ability for successful weight loss options to be developed. The proposed studies aim to fill this gap in knowledge and identify the changes at the level of genes, proteins and lipids that occur during adipocyte hypertrophy. The proposed studies will provide a novel model to study adipocyte hypertrophy in vitro and have the potential to identify potential therapeutic targets for obesity, for example, increasing the expression of Zfp949 in adipocytes.

PI_NAMEs: RUIZ, HENRY H (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TITLE: Zinc Finger Protein 949 as a Potential Transcriptional Suppressor of Adipocyte Hypertrophy - Resubmission - 1

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

NIH_SPENDING_CATS: Allergic Rhinitis (Hay Fever);Digestive Diseases;Eczema / Atopic Dermatitis;Food Allergies;Health Effects of Indoor Air Pollution;Infectious Diseases;Nutrition

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PROJECT_TERMS: aged;airborne allergen;Allergens;Alternaria;Ambrosia;Aspergillus fumigatus;Asthma;Atopic Dermatitis;Betula Genus;Canis familiaris;Cashew nut;Cattle;Cladosporium;Cods;Contractor;cost;Cynodon;dander;Data;Data Collection;Dermatophagoides farinae;Dermatophagoides pteronyssinus;Dictyoptera;egg;Felis catus;Fishes;food allergen;Food Hypersensitivity;German population;Hypersensitivity;IgE;Juglans;Lolium;Manuals;Milk;Mus;National Health and Nutrition Examination Survey;Participant;Penicillium;Proteins;Protocols documentation;pyroglyphid;Questionnaires;Rhinitis;Salsola;Sampling;Serum;Sesame - dietary;Shrimp;soy;Testing;Training;United States National Center for Health Statistics;Urine;Wheat

PROJECT_TITLE: National Health and Nutrition Examination Survey, Allergy Component/Study


ORG_CITY: ALBANY

ORG_DEPT: CHEMISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: PROJECT NARRATIVE Although more than 170 RNA modifications have been identified so far, we only know the function of a few of these, mainly due to technological limitations. The goal of the proposed research is to bring the power of mass laddering technology from proteomics to RNA for developing a direct RNA sequencing and quantitative mapping tool for multiple RNA modifications at single-base resolution all in a single analysis, as a critical step toward elucidating their possible impact on human health.

PI_NAMEs: ZHANG, SHENGLONG  (contact)

PROGRAM_OFFICER_NAME: NOVA, IAN CURTIS

PROJECT_TITLE: Development of Next-Generation Mass Spectrometry-based de novo RNA Sequencing for all Modifications


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Nanotechnology;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: EAST AURORA

ORG_NAME: FLAG BIO, INC.

PI_NAMEs: ANDRIANOVA, KATERINA  (contact)

PROJECT_TERMS: Agonist;anti-influenza;California;cellular transduction;Contractor;COVID-19 vaccine;de-immunization;Dependence;design;Dose;efficacy evaluation;Formulation;Hemagglutinin;Immune response;In Vitro;Influenza;Influenza A Virus, H1N1 Subtype;Influenza Hemagglutinin;influenza infection;Messenger RNA;mouse model;mRNA lipid nano particle vaccine;Mus;Pharmacodynamics;polypeptide;preclinical efficacy;RNA vaccine;Series;Specificity;TLR5 gene;Toxicology;Transcript;Vaccinated;Vaccine Adjuvant;vaccine development;Vaccines;Variant

PROJECT_TITLE: MRNA VACCINE DEVELOPMENT


NIH_SPENDING_CATS: Immunization;Infectious Diseases;Lyme Disease;Prevention;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: LAWRENCE

ORG_NAME: DESIGN-ZYME, LLC

ORG_STATE: KS

PI_NAMEs: PETILLO, PETER A (contact)

PROJECT_TERMS: Adjuvant;Antigens;Borrelia;Contractor;Development;Dose;efficacy study;head-to-head comparison;Hyaluronic Acid;Hyaluronic Acid Binding;immunogenicity;Lyme Disease;Lyme Disease Vaccines;Modeling;mosaic;Mus;OspC protein;Production;Tick-Borne Infections;Vaccine Adjuvant;vaccine efficacy;Vaccines

PROJECT_TITLE: DEVELOPMENT OF COVALENTLY BOUND HYALURONIC ACID AS AN ADJUVANT FOR MULTIVALENT LYME DISEASE VACCINE


NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Lung;Rare Diseases;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: RANCHO DOMINGUEZ

ORG_NAME: MOLECULAR EXPRESS, INC.

PI_NAMEs: HO, SAMON  (contact)

PROJECT_TERMS: Adjuvant;Agonist;Antigens;Aspergillosis;Contractor;Contracts;Development;Liposomes;manufacture;manufacturing process;Neisseria gonorrhoeae;Procedures;Process;Recombinant Proteins;scale up;stability testing;System;TLR7 gene;Vaccine Adjuvant;Vaccines

PROJECT_TITLE: VESIVAX TLR7 FORMULA


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: KNOXVILLE

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: Project Narrative  To meet the increasing demands for safer, yet effective medicines, scientists are using deuterated small molecules to develop novel therapeutics. Despite the tremendous advantages and recent success of deuterated medicines, highly selective chemical reactions to access novel deuterated small molecules and the analytical spectroscopic techniques to support developing these reactions are severely lagging. The proposed research is designed to modernize the synthesis of deuterated small molecules and to advance the field of regioselective aryl alkyne hydrofunctionalization chemistry.

PI_NAMEs: CLARK, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Highly Selective Cu-Catalyzed Reactions for Precision Deuteration and Alkyne Hydrofunctionalization


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: OMAHA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PHR: Project Narrative Neural circuits that transmit sound from the ear to the brain rely on precise connections with their appropriate partners. Disruption of this can lead to sensorineural hearing loss, or “nerve deafness”. The work described here, aims to understand how neural circuits in the auditory system are established in normal hearing to better understand disease, and improve prevention and treatment strategies.

PI_NAMEs: WEBBER, JEMMA LOUISE (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TITLE: Development of Afferent and Efferent Innervation in the Inner Ear

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Nutrition;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PI_NAMEs: BOYD, SCOTT  (contact)

PROJECT_TERMS: Allergens;Allergic;Antibodies;B-Cell Antigen Receptor;B-Lymphocyte Epitopes;B-Lymphocytes;Blood specimen;Cashew nut;Cattle;Cell Degranulation;chicken egg;Clinical;Clone Cells;Epitopes;Exposure to;Food;food allergen;food challenge;Food Hypersensitivity;Goals;Heterogeneity;Human;Hypersensitivity;IgE;IgG1;IgG4;innovation;mast cell;Milk;oral immunotherapy;Patients;Plasma;Proteins;response;Serology;Shrimp;Specificity;Tissue Sample

PROJECT_TITLE: Innovations in Functional B Cell Epitope Discovery for Food Allergy


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: HADLEY

ORG_NAME: VENTUREWELL

PI_NAMEs: MARINO, MARK  (contact)

PROJECT_TERMS: Acceleration;Clinical;commercialization;Diagnostic;diagnostic technologies;Diagnostic tests;Goals;Hepatitis B;innovation;point-of-care diagnostics;RADx;Resources;Services;United States National Institutes of Health

PROJECT_TITLE: RADx Innovation Funnel for Hepatitis B Diagnostics – Commercialization Center


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PI_NAMEs: LAM, WILBUR  (contact)

PROJECT_TERMS: Acceleration;Development;Diagnostic;diagnostic technologies;Diagnostic tests;Hepatitis B;innovation;point-of-care diagnostics;programs;RADx;RADx Tech;United States National Institutes of Health;Validation

PROJECT_TITLE: RADx Innovation Funnel for Hepatitis B Diagnostics - Validation Center


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PI_NAMEs: SCHACHTER, STEVEN C.  (contact)

PROJECT_TERMS: Acceleration;Development;Diagnostic;diagnostic technologies;Diagnostic tests;Hepatitis B;innovation;point-of-care diagnostics;programs;RADx;RADx Tech;United States National Institutes of Health

PROJECT_TITLE: RADx Innovation Funnel for Hepatitis B Diagnostics  - Coordination Center


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: WINSTON-SALEM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Narrative. Metformin has a wide range of beneficial health effects, including promoting healthy aging, and yet the primary molecular mechanism of action of metformin is still unresolved. This project will investigate whether metformin, similar to other positively charged molecules, works by inducing a mild decrease in the efficiency of energy transformation, a primary mechanism that could account for the protection against numerous aging-related diseases.

PI_NAMEs: NEUFER, P DARRELL (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TITLE: Bioenergetics of Metformin Action and Aging


NIH_SPENDING_CATS: Cancer

ORG_CITY: MCLEAN

PROJECT_TITLE: SUPPORT SERVICES FOR SEER PROGRAM CURES funding


NIH_SPENDING_CATS: Bioengineering;Cancer;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: ARLINGTON

ORG_NAME: ACCENTURE FEDERAL SERVICES, LLC

PI_NAMEs: MAHONEY, LISA  (contact)

PROJECT_TERMS: Adopted;Agreement;Businesses;Data;design;Ensure;Environment;Funding;Goals;improved;Information Technology;Malignant Childhood Neoplasm;Mission;National Cancer Institute;Research;software development;Software Engineering;Technology;trend

PROJECT_TITLE: NCI - SOFTWARE ENGINEERING AND SUPPORT_CCDI


ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Many premature infants suffer brain injury due to bleeding within the fluid-filled spaces of the brain that occurs shortly after birth. Currently there is no medical therapy to reduce brain injury in these children. This study will examine the causes of this neonatal brain injury and test therapies to reduce the injury.

PI_NAMEs: MILLER, BRANDON A (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TITLE: Reversing inflammatory macrophage activation as treatment for neonatal intraventricular hemorrhage and hydrocephalus

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Cancer;Nutrition

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PI_NAMEs: WICHTERMAN, BENJAMIN  (contact)

PROJECT_TITLE: Support for PUBLIC USE FOOD FREQUENCY QUESTIONNAIRE.


NIH_SPENDING_CATS: Clinical Research;Pediatric;Prevention

ORG_CITY: OKEMOS

ORG_NAME: MICHIGAN PUBLIC HEALTH INSTITUTE

ORG_STATE: MI

PI_NAMEs: FAULKNER, MEGHAN  (contact)

PROJECT_TERMS: Address;Adolescent;Agreement;Algorithms;authority;Autopsy;Bereavement;biobank;Categories;Centers for Disease Control and Prevention (U.S.);Cessation of life;Child;Collection;Consent;Contracts;Data;Data Coordinating Center;data registry;Data Sources;Deposition;DNA;DNA Sequence;Equipment;Evaluation;Family member;family support;Funding;Goals;Home;Incidence;Institutional Review Boards;Investigation;Learning;Location;loved ones;Maintenance;Medical;Michigan;National Heart, Lung, and Blood Institute;National Institute of Neurological Disorders and Stroke;Population;population based;prevent;Prevention;Prevention program;Process;Progress Reports;Protocols documentation;Registries;Reporting;repository;Research;Research Personnel;Research Support;Resources;review of reported cases;Risk Factors;Sampling;Services;Standardization;Sudden Death;Sudden infant death syndrome;System;Training;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: SUDDEN DEATH IN THE YOUNG CASE REGISTRY (SDY) - DATA COORDINATING CENTER BIOSPECIMEN AND CONSENT ACTIVITIES


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: NARRATIVE Sepsis is a rapid-developing and life-threatening condition caused by the body’s extreme reaction to an infection. Early detection of sepsis-causing agents enables precise treatment and higher chance of survival for patients, but current molecular diagnostic technologies still depend on lengthy blood culture. This MIRA project aims to develop a blood culture-independent sensing device to accurately detect sepsis-causing pathogens in about 2 hours after blood sampling.

PI_NAMEs: LIU, CHANG  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TITLE: Rapid Culture-Independent Detection of Sepsis Causing Microorganism Directly from Blood

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ORG_CITY: BETHESDA

ORG_NAME: TECHNICAL RESOURCES INTERNATIONAL, INC.

ORG_STATE: MD

PROJECT_TITLE: COVID-19: NIAID Regulatory Support Center


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Prevention

PROJECT_TERMS: Age;Agreement;Collaborations;craniofacial;Data;Data Analyses;Dental;Dental caries;Disease;Early Diagnosis;Fluorides;Health;Home;Household;Imaging technology;Implant;improved;improved outcome;Interview;Knowledge;Mission;Mouth Diseases;National Health and Nutrition Examination Survey;National Institute of Dental and Craniofacial Research;Oral;oral condition;Oral Examination;Oral health;Participant;Prevalence;Prevention;Procedures;Quality of life;sealant;Surveys;Testing;Tooth structure;Translating;treatment strategy;United States National Center for Health Statistics;United States National Institutes of Health;Visual;water sampling

PROJECT_TITLE: National Health and Nutrition Examination Survey, Oral Health Component/Study


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHANTILLY

ORG_NAME: FOUR POINTS TECHNOLOGY, LLC

ORG_STATE: VA

PI_NAMEs: LUCAS, LAURIE  (contact)

PROJECT_TERMS: Administrator;Agreement;Area;Attention;Automation;Award;Business Rules;Categories;Classification;Clinical Trials;Code;Collaborations;Communication;Computer software;Conflict of Interest;Contractor;Contracts;Controlled Vocabulary;Custom;Data;data access;Data Analyses;data format;data management;data quality;Data Set;data sharing;Data Sources;Databases;Decision Making;Dedications;design;Development;Device or Instrument Development;Devices;Discipline;Documentation;drug development;Ecosystem;effectiveness analysis;Equity;Evaluation;Evaluation Studies;experience;Experimental Designs;Funding;Funding Mechanisms;Geography;Grant;Guidelines;Impact evaluation;improved;indexing;Individual;Information Systems;Information Technology;Institution;International;Internet;Journals;large datasets;Leadership;Legal patent;Libraries;Machine Learning;Maintenance;Manuals;Manuscripts;Mediation;Medical Device;meetings;member;MeSH Thesaurus;Methodology;mobile application;Modeling;Multi-Institutional Clinical Trial;National Heart, Lung, and Blood Institute;Natural Language Processing;new technology;news;Online Systems;Ontology;open source;Outcome Assessment;Outcomes Research;Output;Peer Review;Performance;Pharmaceutical Preparations;Play;Policies;Process;Program Evaluation;Program Research Project Grants;programs;Property;Protocols documentation;Proxy;Publications;Published Comment;Publishing;Qualifying;Recommendation;Reporting;Research;Research Activity;research and development;Research Institute;Research Personnel;Resource Allocation;Resources;Science;search engine;Secure;Semantics;Services;Shapes;Site;skills;social media;software systems;Source;Standardization;structured data;Study Section;System;Systematized Nomenclature of Medicine;Taxonomy;Technology;Testing;Text;text searching;Time;tool;Training;Unified Medical Language System;United States National Institutes of Health;Update;Validation;virtual;Visualization;Visualization software;web app;web services;web site;Work;Writing

PROJECT_TITLE: NHLBI SCIENTIFIC REVIEW AND SCIENTIFIC PORTFOLIO ANALYSIS (SR/SPA) SOLUTION AND SUPPORT SERVICES WITH ARPA-H SUPPORT (SR/SPA) SERVICES


NIH_SPENDING_CATS: Autism;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

PROJECT_TERMS: Acceleration;Affect;Archives;autism spectrum disorder;biomedical informatics;Brain Diseases;Communication;Data;data archive;Data Collection;data platform;Databases;Diagnosis;flexibility;Genetic;interest;National Institute of Mental Health;Persons;Prevention;repository;Research;Retrieval;Series;System;United States National Institutes of Health;Work

PROJECT_TITLE: THE PURPOSE OF THIS TASK ORDER IS TO SUPPORT THE NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH) DATA ARCHIVE (NDA) IN ACCORDANCE WITH THE INCORPORATED ATTACHMENT 1: STATEMENT OF WORK.


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology

PROJECT_TERMS: 3-Dimensional;Acute;Award;Biological;Biological Models;Biomedical Engineering;Body System;Chemical Exposure;Chronic;Clinical Trials Design;Complex;Disease;drug development;Engineering;Environment;Environmental Exposure;Evolution;Exposure to;Human;improved;in vitro Model;Investigation;Joints;Longevity;microphysiology system;Modeling;Physiological;Process;Research;Space Flight;Specific qualifier value;stressor;Technology;Time;Tissue Microarray;Tissue Viability;Tissues;Translations;United States National Aeronautics and Space Administration;United States National Institutes of Health

PROJECT_TITLE: BIOENGINEERING OF 3D TISSUES AND MICROPHYSIOLOGICAL SYSTEMS TOWARDS LONGEVITY EXTENSION FOR MODELING OF ACUTE AND CHRONIC EXPOSURES TO STRESSORS


PI_NAMEs: GALE, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: WARREN, JON T


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: 3-Dimensional;Address;Adoption;Algorithms;Area;Biological;Biomedical Research;biomedical scientist;Clinical;clinical application;Collaborations;Color;Communication;Defect;Detection;Development;Devices;Diagnostic;diagnostic development;Diamond;Discipline;Disease Marker;early detection biomarkers;Early Diagnosis;Engineering;Functional Imaging;Generations;Health Sciences;Hybrids;imaging modality;improved;Interferometry;International;Light;Magnetic Resonance Imaging;Microscopy;Modality;multidisciplinary;nanodiamond;Noise;Optics;photon-counting detector;photonics;Photons;Physics;quantum;quantum computing;quantum information science;quantum optics;quantum sensing;quantum technologies;real world application;Resources;Scientist;sensor;sensor technology;solid state;Source;Spectrum Analysis;Techniques;Technology;technology development;Testing;therapeutic development;Thermometry;translational impact;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: NIH Quantum Sensing Technology Challenge


PROJECT_TERMS: Address;Adopted;Algorithms;Area;Biological;biomedical imaging;Classification;clinical risk;Communication;Complex;Computational Science;Data Analyses;Department of Energy;Development;Diagnosis;Discipline;DNA;drug discovery;Engineering;Formulation;Generations;genomic data;Hybrids;improved;interest;International;Machine Learning;materials science;Mathematics;Medical Imaging;Methods;Modality;Molecular;novel;Physics;Proteins;quantum;quantum computing;quantum information science;Quantum Mechanics;quantum technologies;risk prediction;RNA Folding;Science;Sequence Analysis;simulation;Speed;Technology;Therapeutic;Treatment Effectiveness;United States National Institutes of Health

PROJECT_TITLE: NIH Quantum Computing Challenge Solve translational biomedical problems with quantum computing


PROJECT_TERMS: Administrator;Biomedical Research;certificate program;Communication;Communities;community organizations;design;Disease;Dissemination and Implementation;Education;Educational workshop;Health;innovation;Knowledge;Literature;Modeling;National Center for Advancing Translational Sciences;novel;outreach;Participant;patient advocacy group;Persons;Prize;Process;programs;Research;Science;science education;Scientist;Series;skills;symposium;Training and Education;training opportunity;translational model;translational progress;Translational Research;web site

PROJECT_TITLE: NCATS Translational Science Education and Training Challenge


ORG_CITY: Arlington

ORG_NAME: DELOITTE CONSULTING, LLP

PI_NAMEs: KOPCHIC, BENJAMIN  (contact)

PROJECT_TERMS: cancer epidemiology;Development;epidemiologic data;web app

PROJECT_TITLE: WEB APPLICATION FOR CANCER EPIDEMIOLOGY DATA


ORG_CITY: CHICAGO

ORG_NAME: AMERICAN COLLEGE OF SURGEONS

PI_NAMEs: MADERA, MARTIN  (contact)

PROJECT_TERMS: Active Sites;Collection;correctional system;Diagnostic Neoplasm Staging;Licensing;Manuals;Performance;Staging System;Update

PROJECT_TITLE: CORRECT THE PERIOD OF PERFORMANCE FOR CLIN 4: ACCESS TO THE 8TH EDITION OF THE CANCER STAGING MANUAL AND THE VERSION 9 CANCER STAGING SYSTEM REQUIRES AN ACTIVE SITE LICENSE. TO CONTINUE COLLECTION AND


NIH_SPENDING_CATS: Cancer;Patient Safety

ORG_CITY: LAKE SUCCESS

PROJECT_TERMS: Institutional Review Boards;minimal risk;Registries

PROJECT_TITLE: CENTRALIZED INSTITUTIONAL REVIEW BOARD (CIRB) FOR MINIMAL RISK REGISTRY LINKAGE STUDIES- FY24


ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Youth with type 1 diabetes (T1D) demonstrate insulin resistance when compared to their peers without diabetes, a feature that predisposes these individuals to diabetic kidney disease and cardiovascular disease, the leading causes of morbidity and mortality in T1D. Metformin, a widely-used insulin sensitizing agent, partially improves peripheral insulin sensitivity and cardiovascular function in youth with T1D; however, it’s effects in combination with innovative diabetes technologies including automated insulin delivery systems remains unstudied. In a randomized, placebo-controlled trial, we will expand our understanding of the effects of metformin used in combination with automated insulin delivery systems on alterations in renal vascular resistance, an early indicator of diabetic kidney disease, as well as whole-body and adipose insulin resistance and cardiometabolic function in youth with T1D to help direct future personalized diabetes care to limit diabetic kidney and cardiovascular disease complications.

PI_NAMEs: TOMMERDAHL, KALIE L (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Acceleration;Address;Adipose tissue;Adopted;Affect;aged;Algorithms;American;Aorta;arterial stiffness;Artificial Pancreas;Attenuated;attenuation;Biometry;Biopsy;Blood Vessels;Body Composition;Body fat;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Physiology;Cardiovascular system;career;career development;Caring;cell injury;Cessation of life;Childhood;Clinical Trials;Complex;Continuous Glucose Monitor;Data Analyses;Data Collection;Dedications;Development Plans;Diabetes Mellitus;Diabetic Nephropathy;Disease;Dose;double-blind placebo controlled trial;Endocrinology;Endothelial Cells;endothelial dysfunction;Endothelium;Environment;euglycemia;experience;Exposure to;fasting glucose;Fatty acid glycerol esters;Foundations;Functional disorder;Funding;Future;Glomerular Filtration Rate;Glucose;Glucose Clamp;glycemic control;Goals;Grant;Hematocrit procedure;Hepatic;high risk;Hybrids;Hyperglycemia;Hyperinsulinism;Hypoglycemia;Immunofluorescence Immunologic;improved;in vivo;Incidence;Individual;Infusion procedures;Injections;innovation;instructor;Insulin;Insulin deficiency;Insulin Infusion Systems;Insulin Resistance;insulin sensitivity;insulin sensitivity/resistance;Insulin-Dependent Diabetes Mellitus;Intervention;Iohexol;Kidney;kidney dysfunction;kidney vascular structure;life span;Measures;Mentorship;Metabolic;Metabolic dysfunction;Metformin;Methods;Morbidity - disease rate;mortality;multidisciplinary;Nephrology;new technology;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;patient oriented research;peer;Performance;Peripheral;Personnel Management;Persons;pharmacologic;pressure;professor;protein expression;Publications;Randomized;randomized placebo controlled trial;Regimen;Renal Plasma Flow;Research;Research Design;Research Methodology;research study;Risk;risk mitigation;Sampling;standard measure;System;Technology;Testing;therapeutic development;Time;Training;Translational Research;Vascular Diseases;Vascular Endothelial Cell;Vascular Endothelium;Vascular resistance;Weight Gain;Work;Youth

PROJECT_TITLE: MANATEE-T1D: Metformin ANd AutomaTEd insulin delivery system Effects on renal vascular resistance, insulin sensitivity, and cardiometabolic function in youth with Type 1 Diabetes

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: SCOTTSDALE

ORG_NAME: VITALANT

ORG_STATE: AZ

PROJECT_TITLE: REDS-IV-P BRAZIL HUB


NIH_SPENDING_CATS: Infectious Diseases

ORG_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

PROJECT_TERMS: Advisory Committees;Blood;Blood Donations;Blood donor;Collaborations;Geography;Hepatitis B;Hepatitis C;HIV;Infection;Intervention;Investigation;meetings;Monitor;National Heart, Lung, and Blood Institute;Organ;Policies;programs;Public Health;Recommendation;Resources;Risk;Risk Factors;Risk Marker;Safety;System;Time;Tissues;Transfusion;transmission process;trend;United States;United States Agency for Healthcare Research and Quality;United States Health Resources and Services Administration;United States National Institutes of Health;Vascular blood supply;Voting

PROJECT_TITLE: Transfusion-Transmissible Infections Monitoring System


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: American;beneficiary;Censuses;Cessation of life;cohort;Communities;Community Surveys;Data;Databases;Economics;Elderly;Environment;Ethnic Origin;health care service utilization;Healthcare;indexing;Information Centers;Medicaid;Medicare/Medicaid;men;Modification;mortality;mortality disparity;mortality statistics;National Heart, Lung, and Blood Institute;Neighborhoods;Occupational;Outcome;Patient Self-Report;Persons;Prospective Studies;Race;social;sociodemographics;socioeconomics;United States Centers for Medicare and Medicaid Services;Vital Statistics;Woman

PROJECT_TITLE: Mortality Disparities in American Communities Study (MDAC)


NIH_SPENDING_CATS: Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Sudden Infant Death Syndrome

PROJECT_TERMS: 20 year old;Address;Autopsy;Bereavement;Categories;Centers for Disease Control and Prevention (U.S.);Childhood;Collaborations;Communities;Data;design;Epidemiology;Evaluation;Event;evidence base;Family;Family member;family support;Geographic Locations;Goals;Incidence;Investigation;Knowledge;loved ones;Medical;National Heart, Lung, and Blood Institute;National Institute of Neurological Disorders and Stroke;Population;population based;prevent;Prevention;prospective;Public Health;Registries;Research;Resources;Risk Factors;Standardization;sudden cardiac death;Sudden Death;Sudden infant death syndrome;sudden unexpected death in epilepsy;Surveillance Program;United States;United States National Institutes of Health

PROJECT_TITLE: Sudden Death in the Young (SDY) Case Registry


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Lung

PROJECT_TERMS: Cardiovascular Diseases;National Health and Nutrition Examination Survey;respiratory health;United States National Center for Health Statistics

PROJECT_TITLE: National Health and Nutrition Examination Survey, Cardiovascular Disease and Respiratory Health Component/Study (NHANES)


ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PHR: This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to understand the basis of pain and enhance clinical pain management.”

PI_NAMEs: MAYER, CHRISTINA  (contact)

PROJECT_TERMS: clinical pain;Cyclic GMP;Helping to End Addiction Long-term;manufacture;Pain;Pain management;Speed;United States National Institutes of Health

PROJECT_TITLE: CGMP MANUFACTURE OF VHCA8* FOR THE TREATMENT OF PAIN


ORG_CITY: WILMINGTON

ORG_NAME: PPD DEVELOPMENT LP

PI_NAMEs: KIRKBY, MATTHEW  (contact)

PROJECT_TERMS: Acceleration;Address;Animal Testing;Award;bench to bedside;biomaterial compatibility;Clinical;Clinical Research;commercialization;Contractor;Contracts;design;Development;Device or Instrument Development;Devices;Diagnosis;Documentation;Face;first-in-human;Funding;Goals;Government;Incubators;Industry;industry partner;Intellectual Property;Investments;manufacture;Marketing;Medical;Medical Device;meetings;Mission;Monitor;Needs Assessment;Nervous System Disorder;new technology;Patients;Phase;pre-clinical;Preparation;programs;prototype;Readiness;Regulatory Affairs;Regulatory Pathway;Research;Research Contracts;Research Personnel;Resources;Risk;Services;System;Technology;Testing;Translations;United States Food and Drug Administration;United States National Institutes of Health

PROJECT_TITLE: CONTRACT RESEARCH ORGANIZATION (CRO) SUPPORT FOR BLUEPRINT MEDTECH (BPMT) REGULATORY AFFAIRS SUPPORT AND RELATED SERVICES. REGULATORY PATHWAY AND MARKET ACCESS SUPPORT. TASK ORDER 03. 04/09/2024 - 04/


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Precision Medicine

ORG_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

PROJECT_TERMS: Academy;Agreement;All of Us Research Program;Architecture;Artificial Intelligence;Cities;cloud based;Collaborations;Complex;Computational Science;computing resources;Data;Data Science;Data Set;Department of Defense;flexibility;Human Resources;Informatics;Information Systems;Mediation;Military Personnel;Modeling;New York;nutrition;Precision Health;precision nutrition;Research Personnel;Resources;System;tool;tool development;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Artificial Intelligence, Modeling, and Informatics for Nutrition Guidance and Systems (AIMINGS) Center


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Health Effects of Indoor Air Pollution;Prevention;Women's Health Research

PHR: Characterizing occupational exposures provides a real-world context for NIEHS toxicology studies. To achieve this, NIOSH will characterize occupational exposures using a multidisciplinary approach to include toxicology, epidemiology, engineering, industrial science, and occupational medicine. These studies contribute to the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents by identifying sources of exposure and strategies for mitigation.

PROJECT_TERMS: Acetates;Acute;Address;Adhesives;Adverse effects;adverse maternal outcomes;Affect;Agreement;air sampling;Area;Birth;Budgets;chemical association;Chemical Exposure;Chemicals;community organizations;Complement;Congenital Abnormality;Contracts;Data;Development;developmental disease;disorder prevention;Employee;Engineering;Enrollment;Environmental Exposure;Epidemiology;epidemiology study;experience;Exposure to;Formaldehyde;Future;Geographic Locations;Gestational Diabetes;Goals;Hazard Assessment;Hazard Identification;Health;Human;Human Subject Research;Industrialization;inorganic phosphate;Institutional Review Boards;interdisciplinary approach;interest;Link;maternal outcome;Measurable;Measurement;Measures;Nail plate;National Institute of Environmental Health Sciences;Occupational;Occupational Exposure;Occupational Medicine;Occupations;Office Management;Ohio;Outcome;Participant;Pennsylvania;Philadelphia;Plasticizers;Polishes;Population;Pregnancy;Protocols documentation;Questionnaires;Recording of previous events;recruit;Reporting;reproductive;Reproductive Health;reproductive outcome;Retrospective Studies;Risk;Sampling;Science;Services;Site Visit;Solvents;Source;Spontaneous abortion;Techniques;Toluene;tool;toxicant;Toxicology;United States;volatile organic compound;Work

PROJECT_TITLE: Assessment of task-based exposures that may affect reproductive health in nail salon employees


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PI_NAMEs: ENGEL, THERESA  (contact)

PROJECT_TERMS: Advanced Development;Affect;Animals;Avian Influenza A Virus;Birds;Cattle;Clinical Trials;Data;Disease Outbreaks;Goals;Influenza;Influenza A Virus, H5N1 Subtype;influenza virus vaccine;National Institute of Allergy and Infectious Disease;Pathogenicity;Phase;phase II trial;Public Health;vaccine development;Vaccines;Variant

PROJECT_TITLE: Clinical Trails to Evaluate H5N1 Influenza Variant Vaccines


NIH_SPENDING_CATS: Health Effects of Indoor Air Pollution;Infectious Diseases;Lung

ORG_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

PHR: These projects characterize the potential exposure to and potential health effects of fungal contamination in the built environment.

PROJECT_TERMS: Acoustics;Address;Aerosols;Agreement;Air;air sampling;Aspergillus;Aspergillus fumigatus;Biological Markers;Brain;built environment;Cardiac;Cardiopulmonary;Cells;Collaborations;Computers;Data;Development;Environment;exposed human population;Exposure to;fungus;Gene Modified;Genomics;Goals;Growth;Health;Health Hazards;Heart;Human;human model;Immunologics;improved;indoor air;Indoor environment;Inhalation;Inhalation Exposure;insight;Knowledge;Liquid substance;Lung;Lung immune response;Methodology;microbial;Mission;Modeling;Molds;mouse model;Mouse Strains;Mus;Mycotoxins;National Institute of Environmental Health Sciences;Neurologic;Occupational;particle;Public Health;Publications;Publishing;Pulmonary arterial remodeling;Reagent;Recovery;Report (document);Reporting;respiratory;response;Stachybotrys;System;systemic toxicity;Tissues;Toxicology

PROJECT_TITLE: Assessment of Inhalation Exposures to Indoor and Occupational Aerosols - Murine Models of Repeated Fungal Inhalation Exposure


NIH_SPENDING_CATS: Clinical Research;Pediatric

PI_NAMEs: NORRIS, PHILIP J. (contact)

PROJECT_TERMS: Adult;Attention;Blood;Blood donor;Blood Transfusion;Brazil;Caring;Charge;Child;Childhood;Collaborations;Collection;Community Hospitals;Contracts;Data;Data Analyses;Data Coordinating Center;Databases;Development;Effectiveness;Ensure;Epidemiology;epidemiology study;Evaluation Studies;Funding;Hospitals;improved;International;Laboratories;Laboratory Study;Link;Manuals;medical specialties;meetings;National Heart, Lung, and Blood Institute;neonate;operation;Pediatric Research;Phase;Procedures;programs;Protocols documentation;Publications;Reporting;Research;Research Personnel;research study;Resources;response;Safety;Services;Site;Test Result;Testing;Training;Transfusion;transmission process;Vascular blood supply;Veins;Work

PROJECT_TITLE: REDS-IV-P CENTER FOR TRANSFUSION LABORATORY STUDIES


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PI_NAMEs: HENDRICKSON, JEANNE E (contact)

PROJECT_TERMS: Adult;Area;Attention;Blood;Blood Banks;Blood donor;Blood Transfusion;Brazil;Caring;Charge;Child;Childhood;Collaborations;Community Hospitals;Contracts;Data;Data Analyses;Data Collection;Data Coordinating Center;data exchange;Databases;Development;Effectiveness;Epidemiology;epidemiology study;Evaluation Studies;Goals;Hospitals;improved;Infrastructure;Laboratories;Laboratory Study;Link;Manuals;medical specialties;meetings;Mentors;National Heart, Lung, and Blood Institute;neonate;operation;Pediatric Research;Phase;Pilot Projects;Policies;Procedures;programs;Protocols documentation;Publications;Research;Research Personnel;research study;Resources;Safety;Services;Shipping;Site;symposium;Transfusion;transfusion medicine;transmission process;United States;Vascular blood supply;Veins

PROJECT_TITLE: REDS-IV-P DOMESTIC HUBS


PI_NAMEs: CUSTER, BRIAN  (contact)


NIH_SPENDING_CATS: Biotechnology;Climate-Related Exposures and Conditions;Health Effects of Indoor Air Pollution;Lung;Pediatric;Social Determinants of Health

PROJECT_TERMS: Acoustics;Aerosols;Agreement;air sampling;Biological Markers;built environment;Computers;Data;Development;Dust;elementary school;Environment;Epidemiology;Evaluation;Event;exposed human population;Exposure to;field study;Floods;Floor;fungus;Future;Genomics;Goals;Health;Health Hazards;Hurricane;improved;indoor air;Inhalation Exposure;Lung immune response;Methodology;Methods;microbial;Mission;Modeling;Molds;Mycotoxins;National Institute of Environmental Health Sciences;next generation sequencing;Occupational;Philadelphia;Public Health;Publications;Publishing;Reagent;Research;Respiratory Tract Infections;response;Risk Assessment;Sampling;Schools;secondary metabolite;Statistical Data Interpretation;symposium;System;Toxicology;Water

PROJECT_TITLE: Exposure Assessment of Indoor and Occupational Aerosols


ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

ORG_STATE: WI

PI_NAMEs: MAST, ALAN E (contact)


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PI_NAMEs: HOD, ELDAD ARIE (contact)


ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative More than 37 million people in the United States have diabetes. Despite many medications for diabetes, the number of deaths resulting from coronary vascular complications, including coronary microvascular disease, is still high among patients with diabetes. This study is designed to identify the cellular defects that cause the abnormalities of small coronary arteries in diabetic patients and to develop new therapeutic approaches for coronary endothelial dysfunction in diabetes.

PI_NAMEs: LEE, YUN SOK ;MAKINO, AYAKO  (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: angiogenesis;Anti-Inflammatory Agents;Apoptosis;Apoptotic;Arteries;arteriole;Atherosclerosis;Attenuated;Blood capillaries;Blood flow;Blood Vessels;Cardiac;Cardiomyopathies;Cardiovascular Diseases;Cell Separation;Cell-Cell Adhesion;Cells;Cessation of life;Chronic;Compensation;Contracts;Coronary;Coronary Arteriosclerosis;Coronary artery;Coronary Vessel Anomalies;Data;Defect;density;design;Development;Diabetes Mellitus;diabetic;diabetic cardiomyopathy;Diabetic mouse;diabetic patient;Distal;Down-Regulation;Endothelial Cells;endothelial dysfunction;Endothelium;Epidemic;Epidermal Growth Factor;Exhibits;Functional disorder;Glycoproteins;Goals;Heart;Heart Diseases;Heart Hypertrophy;Immunosuppressive Agents;improved;Incidence;Inflammation;Inflammatory;Injury;insight;Investigation;Lead;Left ventricular structure;Lipids;Macrophage;Mediating;Microvascular Dysfunction;migration;milk fat globule;Mitochondrial DNA;Molecular;mortality;Mus;Myocardial Ischemia;novel;novel therapeutic intervention;novel therapeutics;Patients;Persons;Phagocytes;Pharmaceutical Preparations;Phenotype;Play;Population;programs;Relaxation;Reporting;Risk Factors;Role;Splenomegaly;Stenosis;Stroke;Testing;Therapeutic Intervention;therapeutically effective;tissue injury;tissue regeneration;tissue repair;Tissues;Treatment Factor;United States;Vascular Endothelial Growth Factors;Vascular Endothelium-Dependent Relaxation;Vascular remodeling;vasoconstriction;Vasodilation

PROJECT_TITLE: Coronary Endothelial Cell Dysfunction in Diabetes: Role of MFGE8

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ORG_CITY: MIDDLETON

ORG_NAME: STANDARD IMAGING, INC.

PI_NAMEs: HOLMES, SHANNON M (contact)

PROJECT_TERMS: Biological;Clinical;clinical translation;Dependence;design,build,test;detector;Development;Doctor of Philosophy;Dose;Dose Rate;dosimetry;Frequencies;Goals;Image;International;irradiation;Measurement;Measures;nanosecond;Normal tissue morphology;novel;optical fiber;Physiologic pulse;preclinical study;Principal Investigator;prototype;radiation detector;Radiation therapy;Reporting;Resolution;response;Structure;System;Technology;Testing;Time;Tissues;tumor;University of Texas M D Anderson Cancer Center

PROJECT_TITLE: TOPIC 461: A NOVEL SCINTILLATION DETECTOR SYSTEM FOR FLASH RADIATION THERAPY


ORG_CITY: LEBANON

ORG_NAME: DOSEOPTICS, LLC

ORG_STATE: NH

PI_NAMEs: BRUZA, PETR  (contact)

PROJECT_TITLE: PHASE I FAST TRACK TOPIC 461 CONFORMABLE SCINTILLATOR ARRAY FOR IN VIVO DOSIMETRY DURING RT


ORG_NAME: PRECISION BIOSERVICES, INC.

PI_NAMEs: LANGENBACH, KURT  (contact)

PROJECT_TERMS: Aliquot;Area;biobank;Biocompatible Materials;Biological;Biological Specimen Banks;Collaborations;Collection;Contractor;Contracts;data repository;Electronics;Equipment and supply inventories;Guidelines;Maintenance;National Heart, Lung, and Blood Institute;programs;quality assurance;Quality Control;Research;Resources;Retrieval;Sampling;Site;Specimen

PROJECT_TITLE: MAINTENANCE OF THE NHLBI BIOLOGIC SPECIMEN REPOSITORYTASK AREA B AND TASK AREA C


PROJECT_TERMS: biobank;Biocompatible Materials;Biological Specimen Banks;Collaborations;Collection;Contractor;Contracts;data repository;Electronics;Equipment and supply inventories;Guidelines;National Heart, Lung, and Blood Institute;programs;quality assurance;Quality Control;Research;Resources;Retrieval

PROJECT_TITLE: NHLBI BIOLOGIC SPECIMEN REPOSITORY


NIH_SPENDING_CATS: Cancer

PI_NAMEs: FINE, JASON  (contact)

PROJECT_TITLE: PREDICTION ERROR MEASURES FOR CONTINUOUS TIME COMPETING RISK MODEL


ORG_CITY: STERLING

ORG_NAME: EXPERIMENTAL PATHOLOGY LABORATORIES

PI_NAMEs: STEINBACH, THOMAS  (contact)

PROJECT_TERMS: analog;Archives;Biological;Biological Specimen Banks;Blood;blood fractionation;Collection;Contractor;Contracts;Data;data repository;digital;digital imaging;DNA;Dust;electronic data;Equipment;Film;Formalin;Freezing;Glass;Hair;Histologic;Human Resources;Intramural Research;Microfilm;Nail plate;National Institute of Environmental Health Sciences;National Toxicology Program;nutrition;Paper;Paraffin Embedding;programs;Qualifying;Records;repository;Research;Research Design;RNA;Sampling;Secure;Services;Slide;Soil;Source;Specimen;Tissue Banks;Tissue Embedding;Tissues;Toxicology;Water

PROJECT_TITLE: MANAGEMENT AND SUPPORT OF AN ARCHIVES AND REPOSITORY CONTRACT FOR THE NATIONAL TOXICOLOGY PROGRAM (NTP) AND THE NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES (NIEHS) DIVISIONS OF TRANSLATIONAL T


ORG_CITY: NEWARK

ORG_STATE: DE

PROJECT_TERMS: clinical pain;Helping to End Addiction Long-term;Pain;Pain management;Speed;testing services;United States National Institutes of Health

PROJECT_TITLE: QPS - PTTP HEAL PK TESTING SERVICES


ORG_CITY: CLIFTON

PROJECT_TERMS: clinical pain;Helping to End Addiction Long-term;Pain;Pain management;Services;Speed;United States National Institutes of Health

PROJECT_TITLE: CMC SME CONSULTING SERVICES


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: HIV/AIDS;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

ORG_CITY: ROCKVILLE

ORG_NAME: FISHER BIOSERVICES, INC.

PI_NAMEs: MARTIN, BRITTANY  (contact)

PROJECT_TERMS: Biological Specimen Banks;Child Development;Child Health;Childhood;Climate;Collection;Contractor;Contracts;cost;Data;Data Collection;Development;Disease;grandchild;Health;Human Development;Maintenance;National Institute of Child Health and Human Development;offspring;Participant;Perinatal;Perinatal Exposure;Process;Research;Research Activity;research study;Resources;sample collection;Sampling;secondary analysis;Services;Shipping;Specimen;Temperature;Time

PROJECT_TITLE: NICHD BIOSPECIMEN REPOSITORY FOR THE LEGACY COLLECTION


ORG_CITY: BETHESDA

ORG_NAME: NOVA RESEARCH COMPANY

PI_NAMEs: EWING, AMY  (contact)

PROJECT_TITLE: SCIENTIFIC MEETINGS AND WORKING GROUP SUPPORT FOR NCI.


ORG_CITY: Paramus

ORG_NAME: PSYCHOGENICS, INC.

ORG_STATE: NJ

PI_NAMEs: HANANIA, TALEEN  (contact)

PROJECT_TERMS: clinical pain;Helping to End Addiction Long-term;National Institute of Neurological Disorders and Stroke;Pain;Pain management;pre-clinical;screening;Speed;United States National Institutes of Health

PROJECT_TITLE: SCREENING OF INVESTIGATIONAL AGENTS THROUGH THE NINDS PRECLINICAL SCREENING PLATFORM FOR PAIN (PSPP)


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

ORG_NAME: THE EMMES COMPANY, LLC

PI_NAMEs: MCCORMACK, JENNIFER  (contact)

PROJECT_TERMS: Helping to End Addiction Long-term;improved;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid use disorder;Prevention trial;Public Health;Research;Speed;Support Contracts;United States National Institutes of Health;Work

PROJECT_TITLE: SUBTHRESHOLD OPIOID USE DISORDER PREVENTION TRIAL (CTN-0101). AUGUST 1, 2024 TO MARCH 31, 2026. N01DA-22-2253. TASK ORDER NO. 75N95024F00004 (TO20).


ORG_CITY: KANSAS CITY

ORG_NAME: MIDWEST RESEARCH INSTITUTE

ORG_STATE: MO

PI_NAMEs: TOMBAUGH, JEANETTE  (contact)

PROJECT_TERMS: clinical pain;Helping to End Addiction Long-term;Pain;Pain management;Speed;United States National Institutes of Health

PROJECT_TITLE: HEAL PROJECT-IHP-102


ORG_CITY: POWAY

ORG_STATE: CA

PHR: This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to understand the basis of pain and enhance clinical pain management.

PROJECT_TERMS: Biological Products;clinical pain;Helping to End Addiction Long-term;Pain;Pain management;Pharmaceutical Chemistry;Speed;United States National Institutes of Health

PROJECT_TITLE: SUBJECT MATTER EXPERT CONSULTANT FOR MEDICINAL CHEMISTRY. NIH BLUEPRINT NEUROTHERAPEUTICS NETWORK(BPN) AND BPN HEAL, BIOLOGICS.


ORG_CITY: LITHIA SPRINGS

ORG_STATE: GA


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pain Research

ORG_CITY: WILMINGTON

ORG_NAME: PPD DEVELOPMENT LP

ORG_STATE: NC

PI_NAMEs: BOYLE, CRAIG  (contact)

PROJECT_TERMS: clinical pain;Dose;Helping to End Addiction Long-term;Pain;Pain management;phase 1 study;Speed;United States National Institutes of Health

PROJECT_TITLE: \SINGLE ASCENDING DOSE (SAD) PHASE I STUDY


ORG_CITY: FRISCO

ORG_STATE: TX

PROJECT_TERMS: Biological Products;Biological Response Modifier Therapy;Chemistry;Clinical Chemistry;Contracts;Development;drug development;drug discovery;Electronic Mail;Feedback;gene therapy;manufacture;member;National Institute of Neurological Disorders and Stroke;novel therapeutics;Phase;pre-clinical;Program Development;Recommendation;Services;symposium;therapeutic development;United States National Institutes of Health

PROJECT_TITLE: This is for Consulting services. POP 10/24/2023 to 10/23/2024


NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Pain Research;Regenerative Medicine

ORG_CITY: MOUNT PLEASANT

ORG_STATE: SC

PROJECT_TERMS: Biological Response Modifier Therapy;Cell Therapy;clinical pain;Development;gene therapy;Helping to End Addiction Long-term;Pain;Pain management;product development;Services;Speed;United States National Institutes of Health

PROJECT_TITLE: BIOLOGICAL THERAPEUTICS PRODUCT DEVELOPMENT SUBJECT MATTER EXPERT CONSULTING SERVICES TO SUPPORT THE DEVELOPMENT OF CELL AND GENE THERAPY PRODUCTS


ORG_CITY: SANBORNTON

PROJECT_TERMS: Address;Chemical Structure;Chemistry;clinical pain;Clinical Research;Collaborations;Contractor;Data;design;Development;drug development;drug discovery;Electronic Mail;Feedback;Helping to End Addiction Long-term;Individual;Lead;lead optimization;member;Methodology;Pain;Pain management;Pharmaceutical Chemistry;Principal Investigator;Process;programs;Reporting;Research;Research Contracts;Role;Services;Speed;Strategic Planning;symposium;Telephone;Testing;United States National Institutes of Health;Visit

PROJECT_TITLE: MEDICINAL CHEMISTRY CONSULTING SUPPORT SERVICES


ORG_CITY: LYME

PROJECT_TERMS: Address;assay development;Biochemical;Biological Assay;Biological Products;Biological Testing;Cells;Clinical;clinical pain;Clinical Research;Collaborations;Consultations;Contractor;design;Development;Development Plans;Electronic Mail;evaluation/testing;experimental study;Helping to End Addiction Long-term;in vitro Assay;Individual;Investigational Drugs;Lead;lead optimization;Logistics;manufacture;Measures;member;Pain;Pain management;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pre-clinical;preclinical evaluation;Principal Investigator;product development;programs;Published Comment;Qualifying;Recommendation;Resources;Role;safety study;safety testing;Serum;Services;Speed;Strategic Planning;Telephone;therapeutic development;timeline;Tissue Sample;Toxicology;United States National Institutes of Health;Validation;validation studies

PROJECT_TITLE: BIOACTIVITY ASSAY DEVELOPMENT CONSULTING SERVICES


ORG_CITY: BOULDER

ORG_STATE: CO

PROJECT_TERMS: Address;assay development;Chemistry;clinical pain;Clinical Research;Contractor;Data;Data Analyses;design;Development;drug development;drug discovery;Drug Kinetics;drug metabolism;Electronic Mail;Experimental Designs;Formulation;Helping to End Addiction Long-term;Investigational Drugs;Lead;lead optimization;Pain;Pain management;programs;Protocols documentation;Recommendation;Reporting;Services;Speed;Telephone;United States National Institutes of Health

PROJECT_TITLE: DRUG METABOLISM PHARMACOKINETICS (DMPK) CONSULTING SUPPORT SERVICES


ORG_CITY: BROOKEVILLE

ORG_STATE: MD

PROJECT_TERMS: assay development;Biological Assay;Biological Products;Biological Response Modifier Therapy;Biotechnology;Cell Therapy;Contracts;Development;drug development;drug discovery;Lentivirus;Modality;Monoclonal Antibodies;National Institute of Neurological Disorders and Stroke;novel therapeutics;Nucleic Acids;peptide drug;Peptides;Program Development;Proteins;Qualifying;Recommendation;Services;Therapeutic;therapeutic development;United States National Institutes of Health;Validation;Viral Vector

PROJECT_TITLE: Biological Therapeutics Bioassay Subject Matter Expert Consulting Services to Support the Development of Therapeutic Biotechnology Products (Biologics)


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CARY

ORG_NAME: ALLUCENT GOVERNMENT SERVICES (US) LLC

PROJECT_TERMS: Address;assay development;Chemistry;Clinical Research;Contractor;Data;Data Analyses;design;Development;drug development;drug discovery;Drug Kinetics;drug metabolism;Electronic Mail;Experimental Designs;Formulation;Investigational Drugs;Lead;lead optimization;programs;Protocols documentation;Recommendation;Reporting;Services;Telephone;United States National Institutes of Health

PROJECT_TITLE: DRUG METABOLISM AND PHARMACOKINETICS (DMPK) CONSULTING SUPPORT SERVICES


PROJECT_TERMS: assay development;Biological Assay;Biological Products;Biological Response Modifier Therapy;Cell Therapy;Contracts;Development;drug development;drug discovery;Lentivirus;Modality;Monoclonal Antibodies;National Institute of Neurological Disorders and Stroke;novel therapeutics;Nucleic Acids;peptide drug;Peptides;product development;Program Development;Proteins;Qualifying;Recommendation;Services;Therapeutic;United States National Institutes of Health;Validation;Viral Vector

PROJECT_TITLE: BIOLOGICAL THERAPEUTICS PRODUCT DEVELOPMENT SUBJECT MATTER EXPERT CONSULTING SERVICES


NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Pain Research

PROJECT_TERMS: assay development;Biological Assay;Biological Products;Biological Response Modifier Therapy;Cell Therapy;clinical pain;Contracts;Development;drug development;drug discovery;Helping to End Addiction Long-term;Lentivirus;Modality;Monoclonal Antibodies;National Institute of Neurological Disorders and Stroke;novel therapeutics;Nucleic Acids;Pain;Pain management;peptide drug;Peptides;product development;Program Development;Proteins;Qualifying;Recommendation;Services;Speed;Therapeutic;United States National Institutes of Health;Validation;Viral Vector


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: CHICAGO

ORG_NAME: IIT RESEARCH INSTITUTE

ORG_STATE: IL

PI_NAMEs: O'RYAN, MICHAEL  (contact)

PROJECT_TERMS: Area;clinical candidate;Communication;Consultations;Contracts;data management;Development;drug development;Drug Kinetics;infrastructure development;Investigational New Drug Application;Lead;Maintenance;Nervous System Disorder;operation;Performance;Pharmacology and Toxicology;pre-clinical;Preparation;programs;research clinical testing;Safety;Stroke;technical report;Testing;Therapeutic;Toxicology;United States National Institutes of Health

PROJECT_TITLE: IITRI - PERFORMANCE AREA 1 TO2


PROJECT_TERMS: base;Biological Response Modifier Therapy;Body System;Development;Dose;drug development;drug discovery;Evaluation;Histology;In Vitro;in vivo;in vivo evaluation;lead optimization;Maximum Tolerated Dose;Microscopic;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Pain;pre-clinical;Preparation;Process;programs;Series;small molecule;therapeutic candidate;Toxic effect

PROJECT_TITLE: MTD-DRF STUDIES-TO 4


ORG_CITY: Waltham

ORG_NAME: PYRAMID TECHNICAL CONSULTANTS, INC.

ORG_STATE: MA

PI_NAMEs: BOISSEAU, RAYMOND P (contact)

PROJECT_TERMS: Ablation;Address;Amplifiers;analog;Animals;Architecture;Area;beamline;Charge;Clinical;clinical application;clinical development;Clinical Research;Collaborations;commercialization;conventional therapy;design;Detection;detector;Development;Devices;Diagnostic Equipment;Dimensions;Dose;Dose Rate;Electric Capacitance;electric impedance;Electrodes;Electron Beam;Electronics;Electrons;Electrostatics;Elements;External Beam Radiation Therapy;fabrication;Failure;Feedback;ferrite;Film;Gases;Goals;improved;innovation;innovative technologies;interest;Ionizing radiation;Ions;irradiation;Lasers;magnetic dipole;Magnetism;Maps;Measures;Medical;Monitor;Nature;Operating System;outreach;Overdose;Patients;Performance;Phase;Photons;Physiologic pulse;Positioning Attribute;Preparation;Process;proton beam;proton therapy;prototype;radiation detector;radiation resistance;Radiation therapy;Reaction Time;Reading;Recording of previous events;Research;Resolution;response;Roentgen Rays;Running;Safety;Scanning;Side;signal processing;Signal Transduction;Small Business Innovation Research Grant;Speed;Structure;System;Techniques;Technology;Testing;Thinness;Time;time interval;transmission process;two-dimensional;Update;Vendor;Work;Writing

PROJECT_TITLE: SBIR TOPIC 434 PHASE II: ULTRA-FAST DOSE RATE (FLASH) RADIATION DETECTORS AND SAFETY SYSTEMSPERIOD OF PERFORMANCE: 16 SEPTEMBER 2024 - 15 SEPTEMBER 2026FIRM FIXED PRICE


NIH_SPENDING_CATS: Bioengineering;Cancer;Networking and Information Technology R&D (NITRD);Radiation Oncology

ORG_CITY: SAINT LOUIS

ORG_NAME: TETRAIMAGING, LLC

PI_NAMEs: JIANG, HAO  (contact)

PROJECT_TERMS: 3-Dimensional;Algorithms;Clinic;Computer software;Data;data acquisition;Development;Devices;Dose;Dose Rate;Electron Beam;Electrons;Goals;Investigation;Ions;Measurement;Measures;Methodology;Modality;Patients;Performance;Phase;Protons;quality assurance;Race;Radiation Oncology;Radiation therapy;reconstruction;Reporting;side effect;Small Business Innovation Research Grant;System;Translating;user friendly software;Validation

PROJECT_TITLE: SBIR TOPIC 434 PHASE II: DEVELOPMENT OF MULTILAYER STRIP ION CHAMBER DEVICE FOR THE MEASUREMENT OF FLASH-RT BEAMSPERIOD OF PERFORMANCE: 9/16/24-9/15/26


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Prevention

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;active duty;Acute;Agreement;Antimicrobial Resistance;Area;beneficiary;Clinical Research;Clinical Trials;Collaborations;Communicable Diseases;COVID-19;design;Disease;Evaluation;HIV;Infection;Infectious disease threat;Infectious Skin Diseases;Influenza;Intervention;Measurement;methicillin resistant Staphylococcus aureus;Military Personnel;Multi-Drug Resistance;multi-drug resistant pathogen;National Institute of Allergy and Infectious Disease;Natural History;Outcome;prevent;Prevention;programs;Publishing;randomized trial;Recording of previous events;Research;Resources;Respiratory Disease;Respiratory Tract Diseases;Services;Sexually Transmitted Diseases;STI prevention;Trauma;Travel;Traveler's diarrhea;Universities;Wound Infection

PROJECT_TITLE: The Infectious Diseases Clinical Research Program (IDCRP)


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: NEW YORK

PROJECT_TITLE: A MONOGRAPH ON SEXUAL ORIENTATION AND GENDER IDENTITY (SOGI) DATA


ORG_CITY: NORTHFIELD

ORG_NAME: COLLEGE OF AMERICAN PATHOLOGISTS

PI_NAMEs: MOLDWIN, RICHARD  (contact)

PROJECT_TITLE: CANCER PATHCHART DATABASE DEVELOPER SUPPORT SERVICES FOR UNIFIED TUMOR SITE- HISTOLOGY STANDARDS.


PROJECT_TERMS: base;Biological Response Modifier Therapy;Contractor;Data;Development;Dose;drug development;drug discovery;Equipment;Generations;Government;Helping to End Addiction Long-term;Human Resources;In Vitro;in vivo;in vivo evaluation;lead optimization;Maximum Tolerated Dose;Nervous System Disorder;Pain;Pathology;pre-clinical;Process;programs;Qualifying;Rodent;Series;Services;small molecule;therapeutic candidate;Toxic effect;Work

PROJECT_TITLE: IITRI - PTTP DRF BPN STUDY - TO3


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PI_NAMEs: MONTGOMERY, RUTH R (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Address;Advisory Committees;Communication;Consultations;cost effective;Data;data repository;data sharing;Data Storage and Retrieval;Decision Making;Ensure;Goals;Human;Immune;Immunology;Institution;Intellectual Property;meetings;Monitor;Publications;Research;Research Project Grants;Resources;success;Technology;vaccine response;Vulnerable Populations

PROJECT_TITLE: Administrative Core


ORG_CITY: WASHINGTON

ORG_STATE: DC

PI_NAMEs: KLEIN, AMANDA  (contact)

PROJECT_TERMS: cancer genome;genome sequencing;Logistics;meetings;patient engagement

PROJECT_TITLE: LOGISTICS AND NETWORK COORDINATION FOR THE PATIENT ENGAGEMENT AND CANCER GENOME SEQUENCING (PE-CGS) NETWORK


ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PI_NAMEs: RETTERER, CARY  (contact)

PROJECT_TERMS: analytical method;cell bank;Cyclic GMP;Development;document outlines;Filtration;Formulation;manufacture;manufacturing test;method development;Nature;Oligonucleotides;Pharmaceutical Preparations;Preclinical Testing;Procedures;Process;Production;Qualifying;Reference Standards;Research;scale up;Site;stability testing;Sterility;Testing;vector;Viral;Work

PROJECT_TITLE: MANUFACTURE AND PRECLINICAL TESTING OF SITE BLOCKING OLIGONUCLEOTIDES (SBO)


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Patient Safety

ORG_CITY: ROCKVILLE

PI_NAMEs: VALMONTE, CLAUDINE  (contact)

PROJECT_TERMS: cancer clinical trial;Clinical Trials;Country;Dedications;Ethics;Human;Individual;Institution;Institutional Review Boards;Methods;Participant;participant enrollment;Research;Research Personnel;Rights;Site;welfare

PROJECT_TITLE: LOGISTICAL AND IT SUPPORT FOR THE NCI CENTRAL INDIVIDUAL REVIEW BOARD (CIRB)


PROJECT_TERMS: Area;Biological;Communication;Communities;Consultations;Contract Services;Contracts;data management;Development;Dose;experience;Goals;indexing;Industry;Infrastructure;Maintenance;National Institute of Neurological Disorders and Stroke;operation;Peptides;Performance;Pharmaceutical Chemistry;Phase;Phase I Clinical Trials;Preparation;programs;Research;research clinical testing;Research Personnel;service providers;Services;small molecule;technical report;Therapeutic;therapeutic development;United States National Institutes of Health;virtual

PROJECT_TITLE: IITRI - NON-GLP DOSE RANGE FINDING (DRF) STUDIES-DEC. 2023 #2