NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: GRUSKY, DAVID B (contact)

PROJECT_TERMS: Address;Affect;Attitude;Behavior;Body Weight;California;Cancer Etiology;cancer prevention;cancer risk;cancer type;Censuses;Collaborations;Communities;community engaged intervention;Community Participation;cost;cost effective;cost effective intervention;cost effectiveness;Country;Data;design;Diet;Employment;evidence base;experimental study;Exposure to;falls;Floor;follow-up;Formulation;Funding;Government;health care quality;Incidence;Income;indexing;Inequity;Influentials;Intervention;Interview;Link;Low income;Malignant Neoplasms;Measures;Methods;mortality;novel;novel strategies;Outcome;Participant;Pathway interactions;Play;Policies;Poverty;Poverty Areas;Predictive Value;Prevention approach;Preventive service;program costs;programs;Quality of Care;Randomized;Research;Research Methodology;Research Project Grants;Rest;Risk Factors;Service delivery model;Services;Site;Smoking;smoking cessation;Social Work;Socioeconomic Status;Stress;Supplementation;Surveys;synergism;Testing;Tobacco use;Training;Update;vaping;Work

PROJECT_TITLE: Project 1


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Electronic Nicotine Delivery Systems;Harm Reduction for Substance Misuse;Lung;Lung Cancer;Precision Medicine;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: CHARLESTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative Most smokers want to quit smoking, and most smokers try to quit smoking each year, but the vast majority of quit attempts end in failure, even when FDA-approved pharmacotherapies are used. The proposed study will investigate the best course of action when following an unsuccessful quit attempt with pharmacotherapy. Results will guide clinical decision making for smoking cessation treatment.

PI_NAMEs: CARPENTER, MATTHEW J;SMITH, TRACY TAYLOR (contact)

PROGRAM_OFFICER_NAME: CICCOLO, JOSEPH THOMAS

PROJECT_TERMS: Abstinence;Adult;Alabama;behavior change;Biochemical;Centers for Disease Control and Prevention (U.S.);Cigarette;Cigarette Smoker;clinical decision-making;clinical practice;Clinical Trials;clinically relevant;Communities;Coping Skills;Data;Decision Making;Dependence;design;Early treatment;Electronic cigarette;evidence base;exhaust;experience;Failure;FDA approved;follow-up;Frequencies;Frustration;Goals;Guidelines;Harm Reduction;Health Benefit;Health Personnel;Individual;innovation;Instruction;interest;Intervention;Learning Skill;Measures;Methodology;Methods;Modality;Nicotine;nicotine patch;nicotine replacement;non-smoking;Oral;Outcome;Participant;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Positioning Attribute;preempt;Prevalence;Randomized;randomized, clinical trials;Recommendation;recruit;Relapse;remote delivery;Research;Research Personnel;Seasons;secondary outcome;Selection Bias;Selection for Treatments;skill acquisition;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;Smoking treatment;South Carolina;success;Testing;Time;Tobacco;tobacco products;treatment responders;treatment trial;varenicline

PROJECT_TITLE: A clinical trial of adaptive treatment for early smoking cessation relapse

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Nutrition

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Food intake can be triggered not only by hunger for calories, but also by deficiencies for specific nutrients, or by need-independent mechanisms. In this proposed study, I will characterize the molecular and cellular mechanisms underlying protein specific appetite, and elucidate how environmental blue light drives eating. This study will thus provide novel insights into the fundamental principles for the organization and modulation of feeding behaviors.

PI_NAMEs: LIU, QILI  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: behavior measurement;Biological Models;Calories;Consumption;Desire for food;Dissection;Drosophila genus;Eating;Electrophysiology (science);feeding;Feeding behaviors;Functional Imaging;Future;Genetic;genetic analysis;Goals;Homeostasis;Hunger;Immunohistochemistry;insight;interdisciplinary approach;Investigation;Light;Mediating;metabolomics;Molecular;Motivation;neural circuit;Neural Pathways;novel;Nutrient;Nutritional;patch clamp;Proteins;Regulation

PROJECT_TITLE: Genetic dissection of motivational drive to eat

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PI_NAMEs: REHKOPF, DAVID H (contact)

PROJECT_TERMS: Address;Advocacy;Agriculture;Behavior;Behavioral;behavioral outcome;California;Cancer Burden;Cancer Control;Cancer Etiology;cancer prevention;cancer risk;Collaborations;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;colorectal cancer screening;Communities;community collaboration;community engagement;community partners;Country;County;design;Diet;Eligibility Determination;Evaluation;evidence base;experience;Family;Food;Healthcare;Home;Household;Housing;Immigrant;improved;Incidence;Income;Income Tax;Individual;Inequality;Inequity;Institution;Interdisciplinary Study;interest;Intervention;Latino;Low Income Population;Persons;Physical activity;Policies;poor communities;Population;Poverty;Poverty Areas;Preventive screening;programs;Qualifying;Quasi-experiment;Research;Research Project Grants;Risk Factors;Risk Reduction Behavior;screening;social health determinants;Social Security Number;stress reduction;structural determinants;success;synergism;Transportation;Universities;urban area;Vietnamese;Work

PROJECT_TITLE: Project 2


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Narrative The proposed request for resource support is to allow continued access for thousands of users to the state-of- the-art technologies important in defining protein-glycan interactions, which are necessary for understanding the expression and functions of glycans in biological systems in health and disease, and glycan recognition by antibodies, glycan-binding proteins (GBPs), and lectins. To date, over 7,000 users and hundreds of laboratories have utilized the NCFG databases and resources, seeking information and assistance related to Functional Glycomics and our Resource research data has led them to explore glycosciences. This Resource provides unique and necessary capabilities in technology, teaching, and service related to understanding protein-glycan interactions to a broad swath of researchers that are experts and non-experts in the field of glycosciences.

PI_NAMEs: CUMMINGS, RICHARD D (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: animal data;Animals;Antibodies;Area;Autoimmunity;Bacteria;base;Binding;Binding Proteins;biological systems;Biomedical Research;cell type;Cells;Collaborations;Communicable Diseases;Communities;Complex Mixtures;Coupling;Data;Databases;density;Derivation procedure;Development;Disease;DNA Library;Educational process of instructing;Ensure;Fluorescence;Funding;Generations;Glycobiology;Glycoconjugates;Glycolipids;Glycopeptides;Glycoproteins;Glycosaminoglycans;glycosylation;gut microbiome;Health;High Pressure Liquid Chromatography;Human;Human Development;Immunology;Improve Access;improved;Individual;innovation;inorganic phosphate;Journals;Label;Laboratories;Lead;Lectin;Libraries;Malignant Neoplasms;Manuscripts;Microarray Analysis;Microbe;microbial;Modification;Molecular Conformation;Monitor;National Institute of General Medical Sciences;Natural Resources;Natural Source;new technology;novel;Oligosaccharides;Organism;Outcome;outreach;pathogenic microbe;Peer Review;Peptide Library;Polysaccharides;Post-Translational Protein Processing;preservation;Printing;Production;programs;Proteins;Publications;Publishing;R24;Recombinants;Research;Research Personnel;Resources;RNA library;Services;Shotguns;Source;success;Sulfate;System;Technology;Tissues;tool;underserved area;Virus;web site

PROJECT_TITLE: Protein-Glycan Interaction Resource at the National Center for Functional Glycomics (NCFG)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative The scientific community has struggled to keep pace with the impact of the changing landscape of cannabis use and policy in the U.S. An important barrier to progress is the lack of adequate measures of cannabis consumption that can be used to identify low vs. high risk use patterns. We propose to address this challenge via a rigorous cannabis measure development / validation project that will enhance the capacities of clinical, epidemiologic and policy studies and lead to more informed communication about cannabis and its risks to clinicians, health educators and policy makers.

PI_NAMEs: BORODOVSKY, JACOB T (contact);HASIN, DEBORAH S

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: Accidents;Address;Adult;age group;Alcohol consumption;Alcohols;American;Benefits and Risks;Biological;Blood specimen;Cannabis;cannabis administration;Cannabis policy;cannabis use behavior;Categories;Clinical;Clinical Research;Clinical Trials;Cognitive deficits;cognitive interview;cognitive testing;Communication;Communities;Community Health;Consumption;cost effective;daily functioning;Data;Data Collection;Development;Dose;drinking;DSM-V;Epidemiology;epidemiology study;Equipment and supply inventories;Ethnic Origin;Face;Family;Family history of;Frequencies;Gender;Geography;Guidelines;handheld mobile device;Health;Health Educators;Health Policy;high risk;Hour;Image;improved;indexing;Industry;Legal;Light;marijuana legalization;marijuana use;marijuana use disorder;marijuana user;Measurement;Measures;Medical;Methods;Modeling;Moods;motor deficit;novel;novel therapeutics;Outcome;Outcome Measure;Participant;Patient Self-Report;Pattern;Policies;Policy Maker;Preparation;Prevalence;Procedures;programs;Public Health;Race;recruit;Reporting;Research;Research Methodology;response;Risk;Route;Sampling;Severities;social media;standardize measure;Statistical Methods;Subgroup;Survey Methodology;Surveys;Terminology;Testing;Therapeutic;Time;Validation;validation studies;Variant;Visual;Work

PROJECT_TITLE: Leveraging Social Media to Develop the Cannabis Exposure Index (CEI), A Standardized Measure of Cannabis Use

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Although anti-Disialoganglioside (anti-GD2) therapy is standard of care for High-Risk Neuroblastoma, it is associated with a highly variable treatment response and life-threatening side effects. The proposed research is relevant to public health because it seeks to identify and characterize novel biomarkers that predict anti- GD2 response in High-Risk Neuroblastoma. The proposed research pertains to the NCI’s mission of improving cancer treatment because there are currently no predictive biomarkers for anti-GD2 response in High-Risk Neuroblastoma and little mechanistic insight into why children fail to respond to treatment.

PI_NAMEs: REBERNICK, RYAN  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: 11q;Address;Affect;Age;Antibodies;antibody-dependent cell cytotoxicity;Biological Markers;biomarker identification;Cancer Model;cancer therapy;CD44 gene;cell type;Cells;Child;Chromosomal Instability;Chromosome Arm;chromosome loss;Clinical;cohort;Data;Data Set;del(11q);Diagnostic;Disease;Dryness;Effectiveness;exome sequencing;experience;fetal;Genes;genetic signature;Genomic Instability;Genomics;Glycolipids;Goals;high risk;Immune;immune cell infiltrate;immune checkpoint;immunohistochemical markers;immunoregulation;Immunotherapy;improved;innovation;insight;Institution;Knowledge;Life;Link;Mediating;Mission;Modeling;Molecular;mouse model;MYCN gene;Natural Killer Cells;neoplastic cell;Neural Crest;Neuroblastoma;new therapeutic target;novel;novel marker;Patient Selection;Patients;precursor cell;predicting response;predictive marker;Process;prognostic signature;Public Health;Research;responders and non-responders;response;response biomarker;risk prediction;Role;Sampling;sialogangliosides;side effect;single cell sequencing;single-cell RNA sequencing;skills;standard of care;Statistical Models;statistics;Surface;Survival Rate;System;Techniques;Testing;Tissues;Toxic effect;Training;transcriptome sequencing;transcriptomics;treatment response;treatment stratification;tumor;tumor microenvironment

PROJECT_TITLE: Dissecting the mechanisms by which chromosomal instability impacts anti-Disialoganglioside responses in neuroblastoma


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: THOMAS, REENA PARADA (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;anti-cancer research;Cancer Etiology;cancer health disparity;Cancer health equity;career;Career Choice;career development;community based participatory research;community engagement;community living;Complement;Comprehensive Cancer Center;Consultations;Data;design;Development;didactic education;Education;Educational Curriculum;Educational workshop;Environment;Evaluation;experience;Faculty;Family;Feedback;flexibility;Funding;Goals;Health Disparities Research;health equity;Healthcare;improved;Income;Inequity;Institution;Intervention;Journals;Malignant Neoplasms;Medical Education;member;Mentors;Participant;peer networks;post-doctoral training;Poverty;Poverty Areas;Program Development;programs;recruit;Research;Research Methodology;Resources;Series;social determinants;social health determinants;synergism;Training;Training and Education;Training and Infrastructure;Training Programs;Universities

PROJECT_TITLE: Career Enhancement Core


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Substance Misuse

ORG_CITY: Boston

ORG_NAME: PASCALL SYSTEMS, INCORPORATED

PHR: PROJECT NARRATIVE Effective nociception monitoring and control during surgery can minimize post-operative pain and reduce post- operative opioid requirements among surgical patients, thereby decreasing their chances of opioid dependency, but existing nociception monitoring tools are imperfect in that they monitor markers such as heart rate and blood pressure that are inherently influenced by various intraoperative factors. This leads to suboptimal opioid administration for nociception control. This project proposes to develop a novel surgical nociception monitor that comprises of an integrated measure of nociceptive control based on neurophysiological (EEG) and autonomic (EDA) markers of arousal and nociception that aren’t susceptible to intraoperative factors.

PI_NAMEs: LE MAU, TUAN  (contact);PURDON, PATRICK L.

PROGRAM_OFFICER_NAME: SABIRZHANOV, BORIS YEVGENYEVICH

PROJECT_TERMS: activity marker;Algorithms;Anesthesia procedures;Anesthetics;Anti-Hypertensive Agents;Applications Grants;Arousal;Blood Pressure;Calibration;Caring;central sensitization;Chronic;Clinical;Clinical Data;cognitive recovery;Data;demographics;design;Dose;Electroencephalography;feature extraction;Galvanic Skin Response;General Anesthesia;Heart Rate;Hemorrhage;improved;Incidence;indexing;Length of Stay;Light;Measures;Methods;Monitor;Morphine;neurophysiology;new technology;Nociception;Nociceptive Stimulus;novel;Operative Surgical Procedures;Opiate Addiction;Opioid;Opioid Analgesics;opioid epidemic;opioid overdose;Outcome;pain score;Patients;Pharmaceutical Preparations;Phase;Physiological;Postoperative Pain;Postoperative Period;Predisposition;prescription opioid;Process;product development;prospective;Public Health;Regulatory Pathway;response;Risk Factors;sensor;signal processing;Small Business Technology Transfer Research;Surgeon;System;Time;Titrations;tool;Uncertainty;Ventilatory Depression;wireless sensor

PROJECT_TITLE: Developing novel technologies to monitor nociception and opioid administration during surgery and general anesthesia in order to minimize post-operative opioid requirements


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: ADAMS, ALYCE SOPHIA (contact)

PROJECT_TERMS: Achievement;Address;Award;broadening participation research;California;Cancer Control;Cancer Etiology;cancer prevention;career;Career Choice;career development;Centers for Population Health;Communities;community engagement;community partners;Comprehensive Cancer Center;Data;Development;Equity;experience;Extramural Activities;Family;Fostering;Funding;Goals;Grant;Health Sciences;Income;Income Tax;Inequality;Inequity;innovation;interdisciplinary collaboration;Intervention;Leadership;Link;Malignant Neoplasms;Mentors;Mission;novel;Pathway interactions;Peer Review Grants;Pilot Projects;Play;Policies;poor communities;Poverty;Poverty Areas;programs;Research;Research Methodology;Research Personnel;San Francisco;Secure;social determinants;synergism;Universities;Work

PROJECT_TITLE: Developmental Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Data Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Infant health and neurodevelopment in early life may be impaired by a wide range of both prenatal and postnatal factors including maternal infection and the socio-behavioral postnatal environment, however research is rarely able to simultaneously measure the impact of each of these factors. In this study, I will use novel multidisciplinary methods to produce estimates of the independent effects of in utero exposure to HIV infection, HIV-related immune perturbations and post-natal environment in HIV-exposed uninfected infants at birth. This project will provide me with training in incorporating multidisciplinary methods in infectious disease research while informing the design and implementation of effective interventions to improve health and development among HIV-exposed uninfected children.

PI_NAMEs: BUCHWALD, ANDREA G. (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: 5 year old;Accounting;Address;Africa South of the Sahara;Age;Area;arm;Bioinformatics;Biological;Biostatistical Methods;Birth;Blood specimen;career;career development;causal model;Child;Child Development;Child Health;Childhood;Clinic;cohort;Cohort Studies;Communicable Diseases;Complex;complex data;Data;data integration;Data Set;Data Sources;design;Development;Development Plans;dimension reduction;disease transmission;diverse data;early childhood;effective intervention;efficacious intervention;Enrollment;Environment;Environmental Risk Factor;Epidemiologist;Equation;Etiology;Evaluation;examination questions;executive function;Exposure to;Faculty;Flow Cytometry;follow-up;Frequencies;global health;Goals;Growth;Health;HIV;HIV Infections;HIV-exposed uninfected infant;Home environment;Immune;Immunity;Immunologic Markers;immunological status;Immunologics;Immunology;Impairment;improved;Infant;Infant Development;Infant Health;Infection;Infectious Disease Epidemiology;Infectious Diseases Research;Inflammation;Inflammatory;innovation;interdisciplinary approach;Interdisciplinary Study;Intervention;Language Development;large datasets;Leadership;Life;Machine Learning;Malawi;Maryland;Maternal and Child Health;maternal wellbeing;Measures;medical schools;Mental Health;Mentors;Methodological Studies;Methodology;Methods;Modeling;Mother-Child Relations;Mothers;Motor;multidisciplinary;Nature;Neonatal;neonatal immunity;Neurocognitive;Neurocognitive Deficit;neurodevelopment;novel;Outcome;postnatal;Pregnancy;prenatal;prenatal exposure;Principal Investigator;Productivity;psychosocial;Public Health;Research;Research Methodology;Research Personnel;Risk;Second Pregnancy Trimester;Severity of illness;skills;Social Behavior;Socioeconomic Status;T-Lymphocyte;Techniques;Testing;therapy design;Training;transmission process;Umbilical Cord Blood;Universities;unsupervised clustering

PROJECT_TITLE: Dissecting the causal impact of prenatal HIV exposure and the postnatal environment on development in Malawian Infants

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Organ Transplantation;Transplantation

ORG_CITY: NEW YORK

ORG_DEPT: SURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE Our overarching aim of this application is to accelerate the discovery of MHC and KIR genetic variants underpinning transplant-related phenotypes/outcomes. To achieve this aim, we will use complementary genomic approaches (short-read and amplicon-based HLA Class I/II second generation sequencing, and long-read sequencing approaches). We will also employ a number of innovative analyses pipelines to maximize the associative potential of very large genetic (genotyping and sequencing) and phenotypic datasets that are derived from well-curated solid organ samples.

PI_NAMEs: KAMOUN, MALEK ;KEATING, BRENDAN JAMES (contact);KIRYLUK, KRZYSZTOF ;SHAKED, ABRAHAM NA

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;Address;Algorithms;Allografting;Amino Acid Motifs;Amino Acids;analysis pipeline;Antigens;Categories;clinically relevant;cohort;Collaborations;Computerized Medical Record;Data;Data Set;Databases;delayed graft function;Disparity;DNA;Electrostatics;end stage disease;Epitopes;Exclusion;exome sequencing;Failure;Generations;Genetic;genetic architecture;genetic association;Genetic Polymorphism;Genetic Research;genetic variant;genome wide association study;genome-wide;Genomic approach;genomic data;Genotype;Haplotypes;Heart;Heart Transplantation;Hematopoietic Stem Cell Transplantation;human leukocyte antigen testing;human subject;improved;Individual;Informed Consent;innovation;International;Kidney;Kidney Transplantation;Life;Ligands;Linkage Disequilibrium;liver transplantation;Lung;Lung Transplantation;Maps;Measures;Methods;Modeling;Natural Killer Cells;Nomenclature;novel;Organ;Organ Transplantation;Outcome;Pathway interactions;Patients;Peptides;Phase;Phenotype;phenotypic data;Pilot Projects;Play;Population;Procedures;Registries;Resolution;Retrospective Studies;risk stratification;Role;Sampling;scaffold;scale up;Serology;SNP genotyping;Solid;Structure;Surface;Training;Translational Research;Transplantation;Variant;Viral

PROJECT_TITLE: MHC and KIR Sequencing and Association Analyses in the iGeneTRAiN Studies


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative The proposed research is relevant to public health, because African Americans/Blacks suffer with higher obesity rates and have more trouble losing weight loss than others. Trained Community Health Workers will deliver the Diabetes Prevention Program (DPP); early during the program, the researchers will identify participants who are not losing weight and the Community Health Workers will offer these participants extra support to help them overcome weight loss barriers. If this extra support works, the National DPP and others can adopt it to achieve better weight loss outcomes among DPP participants, thereby having a significant public health impact.

PI_NAMEs: WILLIAMS, LOVORIA B (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: active control;active control group;Adherence;Adopted;Adult;African American population;Aftercare;Age;arm;Behavior;Black Populations;Black race;Blood Pressure;Body Weight decreased;Centers for Disease Control and Prevention (U.S.);Church;Clinical;clinically significant;Communities;Community Health Aides;cost;Cost Analysis;cost effective;diabetes prevention program;Diet;dietary;Disparity;Disparity population;Early Intervention;Equilibrium;Ethnic Population;Expenditure;experience;Future;Gender;Goals;group intervention;human old age (65+);improved;incremental cost;Individual;Intervention;intervention effect;intervention program;Intervention Studies;Life Style;lifestyle intervention;male;Mediating;Mediation;Mediator;meetings;Mission;Modeling;Morbidity - disease rate;mortality risk;Motivation;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Obesity;Outcome;Outcome Measure;overweight adults;Participant;Pattern;payment;personalized medicine;personalized strategies;Persons;Phase;Physical activity;Population;Prevalence;primary outcome;programs;Psychosocial Factor;Public Health;racial population;Randomized, Controlled Trials;Research;Research Personnel;response;Risk Factors;secondary outcome;Self Efficacy;sex;Site;Social support;sociodemographic variables;Socioeconomic Status;standard care;Standardization;Stress;Structure;success;Telephone;Time;Training;Translations;treatment arm;treatment group;Treatment outcome;United States Centers for Medicare and Medicaid Services;Variant;Weight;weight loss intervention;Work

PROJECT_TITLE: Enhancing the Diabetes Prevention Program to promote weight loss among non-responders in a community based lifestyle intervention

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Our R21/R33 phased innovation proposal aims to build capacity that will fill critical research and practice gaps in cancer, exercise and aging. Our R21 project will develop consensus-based guidelines for exercise in older (65+) cancer survivors that will, in turn, inform the protocol and practices for our R33 project that will establish the feasibility and safety of resistance training in older, functionally limited cancer survivors – a rapidly growing demographic of the cancer survivor population in which we have little specific guidance for using lifestyle-based approaches to preserve their functioning and quality of life.

PI_NAMEs: WINTERS-STONE, KERRI M (contact)

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: Accidents;Activities of Daily Living;Adverse event;Aerobic;Aerobic Exercise;Age;age related;Aging;American;American Society of Clinical Oncology;Cancer Science;Cancer Survivor;cancer therapy;Caring;Cessation of life;Chemotherapy-induced peripheral neuropathy;Clinical;Clinical Oncology;clinical practice;Clinical Trials;Cognitive;college;community advisory board;comorbidity;comparison group;Complex;Consensus;cost;Data Reporting;Delphi Study;Dependence;depressive symptoms;design;Development;disability;Disease;Dose;efficacy trial;Exclusion;Exercise;experience;fall injury;falls;Family;Fatigue;feasibility trial;functional decline;functional improvement;functional outcomes;Funding;Future;Geriatrics;Guidelines;Health;Healthcare Systems;human old age (65+);Impaired cognition;improved;improved outcome;Infrastructure;infrastructure development;Injury;innovation;interdisciplinary collaboration;Intervention;Knowledge;Life Style;Malignant Neoplasms;Medical Oncology;mode of exercise;Modification;novel;older adult;older patient;Older Population;Oncology;oncology trial;Outcome;Pain;Patient Education;Patients;Pharmaceutical Preparations;Phase;phase 1 designs;phase 1 study;phase I trial;Physical Function;Population;Positioning Attribute;Practice Guidelines;preservation;Protocols documentation;Publishing;Quality of life;Recommendation;Research;research in practice;Research Infrastructure;Resistance;resistance exercise;Resources;Risk;Safety;safety and feasibility;scale up;social;Societies;Sports Medicine;Survivors;survivorship;systematic review;Treatment Efficacy;United States National Institutes of Health;Update;Vestibular dysfunction;virtual;working group

PROJECT_TITLE: Advancing Capacity to Integrate Exercise into the Care of Older Cancer Survivors: The ACES initiative to establish guidelines, feasibility and best practices for research in cancer and aging

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PUBLIC HEALTH RELEVANCE STATEMENT: Sepsis is a common and deadly syndrome for which there is no specific treatment other than antibiotics and advanced support. In this project, we will characterize a novel population of neutrophils, assess how the inflammatory mediator eCIRP induces them, investigate how these cells worsen sepsis and the post-sepsis dysfunction, and evaluate the benefit of a new eCIRP inhibitor, A12, on acute sepsis, sepsis survival, and post-sepsis dysfunction. This project will establish the importance of these newly discovered cells for sepsis severity, mortality and late sequelae, and explore a new way to treat septic patients.

PI_NAMEs: WANG, PING  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acute;Acute Lung Injury;Adoptive Transfer;Affect;Affinity;aged;American;Animals;Antibiotics;Antigen Presentation;Attenuated;Binding;Cause of Death;Cells;Cessation of life;Characteristics;effective therapy;Endothelial Cells;extracellular;Functional disorder;Funding;Hospitals;Immune System Diseases;Impaired cognition;in silico;In Vitro;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;innovation;insight;Interferons;Interleukin-12;Lung;migration;Molecular;Morbidity - disease rate;mortality;Names;neutrophil;Neutrophil Activation;Neutrophil Infiltration;novel;novel strategies;Organ;organ injury;Patients;Pattern;Phenotype;Play;Population;prevent;programs;public health relevance;receptor;Reporting;Research;RNA Stability;RNA-Binding Proteins;Role;Sepsis;septic;septic patients;Septic Shock;Severities;Survivors;Syndrome;T-Cell Activation;Th1 Cells;Therapeutic;tissue injury

PROJECT_TITLE: Novel Approaches to Maintaining Organ Function in Sepsis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ORG_CITY: SEATTLE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Due to the high prevalence of obesity and obesity-associated co-morbidities in the United States and globally, there is an ongoing need to identify effective and safe long-term treatment options for obese patients. We seek to improve public health by exploring ALDH1A1 as a new target for obesity therapy. Successful completion of our studies will validate this new target and provide new drugs to treat obesity.

PI_NAMEs: PAIK, JISUN  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Acceleration;Adipocytes;Adipose tissue;Adult;Affect;Agreement;Alcohols;aldehyde dehydrogenases;ALDH1A2 gene;American;Animals;Attenuated;Biological Assay;Biological Markers;Biology;biomarker identification;Birth;Body Temperature;Body Weight decreased;Calories;Clinical;Clinical Pathology;Clinical Protocols;comorbidity;Complement;Contraceptive Usage;Data;Desire for food;Development;Diet;diet-induced obesity;dietary;efficacy evaluation;efficacy testing;Embryo;Energy consumption;Energy Metabolism;Enzyme Inhibitor Drugs;Enzymes;Fatty acid glycerol esters;Fatty Acids;feeding;Female;Future;Gene Expression;Glucose;glucose metabolism;Goals;Health;Hepatic;High Fat Diet;High Prevalence;Histopathology;Human;Hypertrophy;Immunity;improved;in vivo;inhibitor;innovation;insight;Knowledge;Label;lipid biosynthesis;lipid metabolism;Lipoidosis;Liver;male;Male Contraceptive Agents;Mediating;Metabolic;metabolic profile;metabolomics;Methods;Modeling;mouse model;Mus;Muscle;new therapeutic target;novel;novel therapeutics;Obese Mice;obese patients;Obesity;obesity treatment;Oral;Organ;Pathology;Pattern;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacological Treatment;Phenotype;Physiology;potential biomarker;prototype;Public Health;Pyruvate;Regression Analysis;Regulation;Reporter;Reproduction;Resistance;response;Retinoids;Role;Safety;sex;side effect;small molecule;Specificity;Spermatogenesis;Statistical Models;Systems Biology;Testing;Testis;Tissue Differentiation;Tissues;Toxic effect;translational potential;Treatment Efficacy;Treatment-related toxicity;Tretinoin;United States;Validation;Visceral;Vitamin A;Weight;Weight Gain

PROJECT_TITLE: Validation of ALDH1A1 as a target for the treatment of obesity: effects of ALDH1A1 inhibition on energy metabolism

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROGRAM NARRATIVE Protein-protein and protein-DNA interaction (PPI and PDI) networks control virtually all cellular processes, and they are commonly perturbed by devastating human diseases. To overcome key challenges in interaction network analysis, we will develop novel, transformative bioanalytical methods to quantify cellular PPI and PDI networks and their dynamic perturbation in disease, thereby enabling groundbreaking, broadly relevant discoveries of disease mechanisms and drug targets. We will apply our methods to unravel the interaction networks that control cellular plasticity, a biological process driving diverse pathological processes, including cancer metastasis, organ fibrosis, viral infection, drug resistance, and immune escape.

PI_NAMEs: GOLKOWSKI, MARTIN  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Affinity;Automobile Driving;Biological Process;Biology;Cell Nucleus;Cell Physiology;Cells;Chemicals;chemoproteomics;Chromatin;Creativeness;crosslink;Development;Disease;disease phenotype;Disease Progression;DNA-Protein Interaction;Drug resistance;Drug Targeting;epigenomics;Fibrosis;Fostering;Genetic Transcription;Genomics;Goals;Human;human disease;Immune;In Situ;inhibitor;insight;Label;Link;Maps;Mass Spectrum Analysis;Methods;Molecular;Neoplasm Metastasis;next generation;novel;Nuclear;Organ;Pathologic;Pathologic Processes;Pathway Analysis;Pathway interactions;Permeability;Phosphotransferases;Physiological;Post-Translational Protein Processing;Productivity;programs;Protein Kinase;Proteins;Proteomics;Research;Resistance;Signal Transduction;spatiotemporal;Technology;tissue repair;Training;transcription factor;transcriptomics;transdifferentiation;virtual;Virus Diseases

PROJECT_TITLE: Integrated mass spectrometry-based chemoproteomic and genomic technologies for studying dynamic kinase interactomes


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Depression is one of the most debilitating psychiatric illnesses to emerge during adolescence, a period of critical brain development and transition towards adulthood. Cognitive and motivational deficits are prominent symptoms and the associated neural systems undergo adolescent-specific development, making understanding cognitive and motivational neurobehavioral interactions in adolescent depression crucial to designing future treatments and prevention strategies. This study proposes complementary approaches to examine cognitive-motivational neurobehavioral interactions, using: an incentivized spatial working memory neuroimaging paradigm in adolescents with depression, with longitudinal re-examination, and data-driven approaches applied to a large-scale dataset in typical children aimed at characterizing cognitive-motivational phenotypes as a platform for future studies to examine depression risk in adolescence.

PI_NAMEs: CHO, YOUNGSUN T (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 14 year old;Accidents;Adaptive Behaviors;Adolescence;Adolescent;Adolescent Psychiatry;Adult;adverse outcome;Behavior;Behavioral;blood oxygen level dependent;Brain;career;Cause of Death;Child;child depression;Child Psychiatry;Cognition;Cognitive;Cognitive deficits;cognitive development;cognitive process;cohort;Communities;Complement;Corpus striatum structure;critical period;Cross-Sectional Studies;Data;design;Development;diagnostic criteria;Dopamine;Emotions;Exhibits;experience;financial incentive;Functional Magnetic Resonance Imaging;Future;Goals;Heterogeneity;Homicide;Image;Impairment;improved;Incentives;innovation;Knowledge;large scale data;Longitudinal Studies;Maps;Measures;Mental Depression;Mental disorders;Mentors;Mentorship;Methodology;Methods;Motivation;motivational processes;multidisciplinary;myelination;neural;neural circuit;neurobehavioral;Neurobiology;neuroimaging;nonhuman primate;Outcome;Participant;Pediatric cohort;peer;Performance;Phenotype;Physicians;Positioning Attribute;Prevention strategy;Psychopathology;Publishing;rate of change;Relapse;Research;Research Design;Research Personnel;response;reward anticipation;Rewards;Risk;Sampling;Scientist;Shapes;Short-Term Memory;Signal Transduction;Site;Specificity;Suicide;Symptoms;System;Techniques;Testing;Thinness;Training;transition to adulthood;Translating;treatment strategy;Variant;Ventral Striatum;Visit;young adult

PROJECT_TITLE: Examining Longitudinal Cognitive-Motivational Interactions in Adolescents with Depression

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: GALVESTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Emerging and tropical infectious diseases are an important public health concern. Yet, there are insufficient numbers of trained investigators to undertake related research, especially for vector-borne diseases. This program will address this shortage by training future outstanding investigators in a dynamic environment.

PI_NAMEs: SOONG, LYNN  (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: emerging tropical infectious disease

PROJECT_TITLE: Emerging and Tropical Infectious Diseases

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Diabetes;Eye Disease and Disorders of Vision;Hematology;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE  We identified that the bone marrow of the skull bone (calvarium) unlike other bone marrow compartments is protected from the adverse impact of diabetes and supplies vascular reparative cells to the retinal until the late-stage diabetes occurs. We postulate that this protection is due to the direct connection between the calvarium and the cerebral spinal fluid (CSF) as the CSF provides the calvarium with brain- derived protective hematopoietic factors. We will identify these protective factors in the CSF and also deliver a drug to the calvarium of late stage diabetic mice to determine if we can restore levels of bone marrow-derived vascular reparative cells back to normal.

PI_NAMEs: BUSIK, JULIA V;GRANT, MARIA BARTOLOMEO (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Adrenergic Agents;Age;Agonist;Autonomic nervous system;Back;Blood capillaries;Blood Vessels;bone;Bone Marrow;Bone Marrow Cells;Brain;Calvaria;Cell membrane;cell motility;Cell Separation;Cells;Cerebrospinal Fluid;Cholesterol;Chronic;Complications of Diabetes Mellitus;cranium;db/db mouse;Denervation;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Retinopathy;Disease;Disease Progression;Dura Mater;Endothelium;Equilibrium;Fatty acid glycerol esters;Flow Cytometry;Functional disorder;Generations;Growth Factor;Hematopoiesis;Hematopoietic;Human;Hydrogels;Immune;Immunohistochemistry;immunoregulation;improved;Inflammation;Inflammatory;injured;Injury;Insulin-Dependent Diabetes Mellitus;Intraventricular;Ligands;Liver X Receptor;long bone;Macrophage;mad itch virus;Membrane Fluidity;Metabolic;Metabolic stress;Microscopic;Modeling;monocyte;Mus;Myelogenous;Myeloid Cells;Myelopoiesis;nerve supply;neurogenesis;Neurons;neurotrophic factor;neurotropic;Non-Insulin-Dependent Diabetes Mellitus;novel;Pathogenesis;Pathologic;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Physiological;Population;postnatal development;prevent;progenitor;Proliferating;protective factors;Proteins;Rattus;Receptor Activation;recruit;Red Marrow;repair function;repaired;Reporter;resilience;Resistance;response;Retina;Rodent Model;Role;single-cell RNA sequencing;Source;stem;Streptozocin;Stromal Cells;Sympathetic Nervous System;systemic inflammatory response;targeted delivery;Testing;Therapeutic;Time;Tissues;Tyrosine 3-Monooxygenase;Vascular blood supply;Yellow Marrow

PROJECT_TITLE: Hematopoietic cell mobilization from distinct bone marrow compartments following retinal injury

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Project Narrative Infections with Mycobacterium tuberculosis remain a worldwide public health concern causing over 1.5 million deaths annually. We found that the glycerol synthase kinase 3a and 3b (GSK3a/b) are required for host responses by controlling the activation of macrophages by the essential cytokine Interferon-gamma (IFNγ). Here, we will understand the mechanisms of GSK3a/b control of IFNγ signaling and dissect the contribution of GSK3a/b to IFNγ-mediated control of M. tuberculosis growth, inflammation and T cell responses.

PI_NAMEs: OLIVE, ANDREW  (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: adaptive immune response;Address;Antigen Presentation;Antigen-Presenting Cells;Automobile Driving;Bacterial Model;Cause of Death;CD4 Positive T Lymphocytes;Cell Communication;Cell Physiology;Cells;Cessation of life;Chemicals;Chronic;Communicable Diseases;Complex;Coupled;CRISPR screen;cytokine;Data;Development;Disease;Disease Progression;Disputes;effective therapy;effector T cell;engineered T cells;Epidemic;Equilibrium;Genes;genetic approach;Genetic Screening;genome-wide;Glycerol;Glycogen Synthase Kinases;Goals;Growth;Immune;Immune Evasion;Immune response;Immunity;in vivo;in vivo Model;Infection;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;interdisciplinary approach;Interferon Type II;Kinetics;Knowledge;Lead;Lung;Lung Diseases;Macrophage;Macrophage Activation;Mediating;Mediator;Metabolic;Mus;Mycobacterium tuberculosis;Myelogenous;novel therapeutics;Outcome;paralogous gene;pathogen;Pathogenesis;Pathologic;Pathway interactions;Phosphotransferases;Play;prevent;Production;protective pathway;Public Health;Regulation;response;Role;Shapes;Signal Transduction;Structure of parenchyma of lung;Surface;T cell response;T-Cell Activation;targeted treatment;Testing;Time;Tissues;transcriptome;Tuberculosis;Vaccines;Virulence

PROJECT_TITLE: Regulators of IFN-gamma responses during Mycobacterium tuberculosis infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


PHR: PROJECT NARRATIVE β-Cell dysfunction and depletion are pathologic features of type 1 diabetes. A method for β-cell-targeted drug delivery is required to realize the goal of developing a regenerative therapeutic for diabetes. The extraordinary power of medicinal chemistry and the unique biology of β-cells will be combined to generate novel β-cell-targeted regenerative compounds; the underlying technology may be applied to nearly any small molecule.

PI_NAMEs: ANNES, JUSTIN PIERCE (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Antibodies;Autonomous Replication;Beta Cell;Biochemical;Biological;Biological Assay;Biology;biophysical properties;blood glucose regulation;Cell Lineage;Cell membrane;Cell Membrane Permeability;Cell Proliferation;Cell surface;cell type;Cells;Cellular Assay;cellular targeting;Chemicals;Coculture Techniques;Data;Daughter;Dependence;design;Diabetes Mellitus;Diabetic mouse;Dose;Drug Delivery Systems;Drug Kinetics;Drug Targeting;Endosomes;Ensure;extracellular;Functional disorder;Generations;glucose tolerance;Goals;growth promoting activity;Histology;Human;Human Cell Line;humanized mouse;Impairment;In Vitro;in vivo;innovation;Insulin;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans Transplantation;Lead;Measures;Mediating;Membrane;Methods;Modeling;Molecular;Mus;Natural regeneration;Neuroendocrine Cell;next generation;novel;Pathologic;peptidylglycine alpha-amidating monooxygenase;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;pre-clinical;Pre-Clinical Model;prevent;Prodrugs;Production;Protein Isoforms;Recombinants;regenerative;regenerative therapy;regenerative treatment;restoration;screening;Secretory Vesicles;small molecule;Specificity;Structure-Activity Relationship;success;targeted delivery;targeted treatment;Technology;technology platform;Therapeutic;Tissues;trafficking;Transplantation;Treatment Efficacy;Work

PROJECT_TITLE: Developing A Platform Technology For β-Cell-Targeted Drug Delivery


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PUBLIC HEALTH RELEVANCE: Telomeres are specialized structures located at the ends of chromosomes that fulfill an essential role in maintaining genetic integrity and cancer prevention. However, cancer causing mutations can bypass this arrest in cell division and re-initiate cellular division. These cells must also re-activate a mechanism that ensures that telomeres once again maintain the structural integrity of chromosomes but are no longer capable of blocking cell division. This is achieved by activating one of two different telomere maintenance mechanisms. One of these mechanisms is known as alternative lengthening of telomeres, or simply ALT. Cancers that rely on ALT tend to be among the most aggressive and patients often have a poor prognosis. Therefore, understanding the molecular basis for the activation and maintenance of the ALT pathway and identifying the key regulators of ALT is critically important for improving the detection and treatment of this devastating disease.

PI_NAMEs: O'SULLIVAN, RODERICK  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Address;Adenosine Diphosphate Ribose;ADP ribosylation;Affect;ATRX gene;Biochemical;Biological Assay;Bypass;cancer cell;Cancer Etiology;cancer prevention;cancer therapy;Cancerous;Cell division;Cell Survival;Cells;cellular targeting;Chromatin;Chromatin Modeling;chromatin modification;chromatin remodeling;Chromatin Remodeling Factor;Chromosomes;Complex;DAXX gene;defined contribution;Deposition;Detection;Disease;Dissection;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Sequence Alteration;Ensure;Enzymes;Genes;Genetic;Genetic Transcription;Genome;Glycoside Hydrolases;Goals;Histone H3.3;histone modification;Histones;Homeostasis;Impairment;improved;Individual;innovation;Knowledge;Length;Licensing;Maintenance;Malignant Neoplasms;Measures;Mediator;Metabolism;Molecular;Molecular Chaperones;mutant;Mutate;Mutation;novel strategies;Nucleosomes;Optics;Pathway interactions;Patients;Phase;Poly Adenosine Diphosphate Ribose;poly ADPR glycohydrolase inhib;preservation;Process;Prognosis;Proteomics;public health relevance;recruit;Recurrence;Regulation;Repair Complex;repaired;Repression;Research;response;Role;sensor;Serine;Stress;Structure;synergism;targeted cancer therapy;telomere;Telomere Maintenance;Telomere Pathway;therapeutic target;therapy development;Untranslated RNA

PROJECT_TITLE: Inhibition of the ALT pathway by interfering with Poly-ADP-Ribose metabolism

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Relevance: More than 40% of HIV-1 infected people on anti-retroviral drug (ARD) therapies have early-onset diastolic heart failure (dHF), a harbinger for adverse clinical outcomes including frequent hospitalizations and sudden death. To date, the molecular reasons for the development of dHF remain poorly understood. This multi-PI project brings together the expertise of Drs. Keshore R. Bidasee (cardiovascular diseases including heart failure) and Santhi Gorantla (humanized mice and HIV-1 infection) with assistance from Dr. Prasanta Dash (HIV-1 eradication and cardiovascular complications), to characterize novel link between glycolysis and heart failure in the setting of HIV infection and ARD, paving the way for the development of urgently needed drugs to attenuate dHF in people living with HIV infection.

PI_NAMEs: BIDASEE, KESHORE R (contact);GORANTLA, SANTHI

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: Anti-Retroviral Agents;Area;Arteriosclerosis;Attenuated;Autopsy;Biochemical;Biological Assay;Blood Vessels;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;Cell Culture Techniques;Cells;Chronic;chrysin;Clinical;Coronary;cytotoxic;Data;Development;Diabetes Mellitus;Diastolic heart failure;Disease;early onset;emtricitabine;Endothelial Cells;Endothelium;Enzymes;Extravasation;Fibrosis;Fumarates;Functional disorder;Gene Transfer;Genus Hippocampus;Glycolysis;Health Care Costs;Heart;Heart Diseases;Heart failure;Hemoglobin;HIV;HIV Infections;HIV-1;Homeostasis;Hospitalization;Hospitals;humanized mouse;Hypoxia;Hypoxia Inducible Factor;Impairment;in vivo;Individual;Infection;Inflammation;inhibitor;innovation;Ischemia;Kinetics;Lactoylglutathione Lyase;Link;Lung;Macrophage;MAP Kinase Gene;Measures;Mediator;Modeling;Molecular;mouse model;Mus;Muscle Cells;Myocardial Infarction;Myocarditis;Nitric Oxide;normal aging;novel;novel therapeutics;Outcome;Oxidative Stress;Oxygen;p38 Mitogen Activated Protein Kinase;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;photoacoustic imaging;Plasma;prevent;Production;Publishing;Pulmonary Hypertension;Pyruvaldehyde;Recommendation;Regimen;Research;seropositive;sex;Smooth Muscle Myocytes;Sudden Death;systemic inflammatory response;Tenofovir;Therapeutic;Time;Tissues;tool;transcription factor;Triose-Phosphate Isomerase;Up-Regulation;Viral;Viremia;Virus;Virus Replication;Visit

PROJECT_TITLE: Diastolic Heart Failure in HIV-1 infection


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE_OVERALL The goal of this Center is to validate and optimize the use of botanical dietary supplements that are reputed to enhance resilience to loss of function that can occur during aging.

PI_NAMEs: SOUMYANATH, AMALA  (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Achievement;Age;age group;Aging;aging related;Alzheimer's Disease;analytical method;Ashwagandha;Biological;Biological Markers;Botanical dietary supplements;Botanicals;Brain;brain tissue;career development;Clinical Research;Clinical Trials;Clinical Trials Design;Cognition;Coupled;Crude Extracts;Data;data management;design;Dose;Drosophila melanogaster;Education;efficacy testing;Elderly;Ensure;faculty mentor;Funding;Future;Gender;Goals;Gotu kola;graduate student;Grant;Health;Impaired cognition;In Vitro;in vivo;Infrastructure;Lead;Link;Liquid Chromatography;loss of function;Mass Spectrum Analysis;Measures;metabolomics;Methods;Modeling;Moods;Mus;Neurologic;Neurons;novel;Oregon;Participant;Perfusion;Phase;Phase III Clinical Trials;Phytochemical;Plant Extracts;Plasma;Population;Positioning Attribute;Postdoctoral Fellow;pre-clinical research;preclinical study;Preparation;Process;programs;promote resilience;Quality of life;Quinic Acid;Reporting;Research;Research Activity;Research Institute;Research Personnel;Research Project Grants;Research Training;resilience in aging;Resolution;response;Scientist;Sleep;Sleep Deprivation;Sleep disturbances;Slice;sound;Source;Target Populations;targeted biomarker;Techniques;Testing;Tissues;transcriptomics;Translational Research;translational study;Triterpenes;United States National Institutes of Health;web site;Work

PROJECT_TITLE: Botanicals enhancing neurological and functional resilience in aging (BENFRA)


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Complementary and Integrative Health;Depression;Dietary Supplements;Mental Health;Natural Products;Neurosciences;Nutrition;Sleep Research

PI_NAMEs: GRAY, NORA  (contact)

PROJECT_TERMS: Acids;Affect;affective disturbance;Age;age related;age related changes;Age-associated memory impairment;Aging;aging related;Alzheimer's Disease;animal old age;Animals;Anti-Anxiety Agents;Antioxidants;Anxiety;arterial spin labeling;Ayurvedic Medicine;Behavior;Behavior assessment;Behavioral;Biological Markers;Blood;blood perfusion;Botanicals;Brain;Brain imaging;Chinese Traditional Medicine;Chronic;clinical development;Clinical Trials;Clinical Trials Design;Cognition;Cognitive;cognitive change;cognitive enhancement;cognitive function;cognitive performance;Data;density;depressive symptoms;DNA Methylation;Dopamine;dosage;Dose;Drug Kinetics;efficacy evaluation;Elderly;Electroencephalography;executive function;experimental study;F2-Isoprostanes;Failure;Food;Formulation;Future;gamma-Aminobutyric Acid;Goals;Gotu kola;Health;healthy aging;Herb;Hormones;Human;human subject;Hydrocortisone;Impaired cognition;improved;improvement on sleep;In Vitro;in vivo;in vivo evaluation;juvenile animal;Knowledge;Learning;Life;Magnetic Resonance Spectroscopy;Measures;Memory;Mental Depression;metabolomics;Methodology;Methods;methylation pattern;Mitochondria;Moods;mouse model;Mus;Nerve;Neurologic;Neurons;Neurotransmitters;old mice;older adult;Oral Administration;Pathway interactions;Pattern;Perfusion;peripheral blood;Phenotype;Plant Extracts;Plants;Plasma;Population;pre-clinical;pre-clinical research;preclinical study;Prevalence;promote resilience;Psyche structure;Quality of life;Rapid screening;Reporting;research clinical testing;resilience;resilience in aging;response;Rodent Model;Serotonin;Sleep;Sleep Deprivation;Sleep disturbances;sleep spindle;Sleeplessness;Synapses;System;targeted biomarker;Testing;Traditional Medicine;Translations;Water

PROJECT_TITLE: Botanicals for functional resilience to aging: identifying in vivo biomarkers of the effects of Centella asiatica (Project 1)


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Complementary and Integrative Health;Dietary Supplements;Natural Products;Neurosciences;Nutrition;Sleep Research

PI_NAMEs: KRETZSCHMAR, DORIS  (contact)

PROJECT_TERMS: Acetylcholine;Acids;Address;Affect;Age;age related changes;age related decline;age related neurodegeneration;Aging;Antioxidants;Arylalkylamine N-Acetyltransferase;Ashwagandha;Attention;Ayurvedic Medicine;Biological Assay;Blood Vessels;Botanical dietary supplements;Botanicals;Brain;Chemicals;Choline O-Acetyltransferase;Clinical Trials;Cognition;Cognitive;constriction;Coupled;Courtship;Crude Extracts;design;Dose;Drosophila genus;Drosophila inturned protein;Drosophila melanogaster;Elderly;Electron Transport;Evaluation;experimental study;Fingerprint;fly;Future;GABA Receptor;gamma-Aminobutyric Acid;Gene Expression;Glycosides;Goals;Gotu kola;Head;Health;Herb;Hippocampus;Human;Immunohistochemistry;improved;In Vitro;in vivo;in vivo Model;Individual;inhibitor;insight;Invertebrates;Lactones;Liquid Chromatography;Locomotion;madecassic acid;Mammals;Mass Spectrum Analysis;Materials Testing;mating behavior;Measures;Mediating;Mental Depression;Mitochondria;Modeling;Molecular;Moods;mouse model;Mus;neural;Neurologic;Neurons;Neurotransmitters;neurotropic;Oxidative Stress;Parents;Pathway interactions;Population;promote resilience;Proteins;Reactive Oxygen Species;resilience;resilience in aging;Resolution;response;Response Elements;Rodent Model;Role;Serotonin;Signal Transduction;Sleep;sleep pattern;sleep regulation;Slice;Statistical Methods;Symptoms;Synapses;Testing;Triterpenes;vasoconstriction;vibration;Water

PROJECT_TITLE: Mechanism based evaluation of botanical bioactive compounds enhancing neurological resilience (Project 2)


NIH_SPENDING_CATS: Aging;Complementary and Integrative Health;Dietary Supplements;Natural Products;Neurosciences;Nutrition

PI_NAMEs: MAIER, CLAUDIA S (contact)

PROJECT_TERMS: Acids;Aging;aging population;analytical method;animal tissue;Animals;Ashwagandha;Attention;Bar Codes;Biological;Biological Assay;Biological Availability;Botanical dietary supplements;Botanicals;Brain;chemical fingerprinting;Chemicals;Chemistry;Chromatography;Clinical Trials;Cognition;Collaborations;Coupled;Data;Drug Kinetics;Fingerprint;Funding;Future;Gene Expression;Genes;Gotu kola;Harvest;Herb;High Pressure Liquid Chromatography;in vivo;interest;Liquid Chromatography;Literature;Mass Spectrum Analysis;Materials Testing;metabolomics;Methodology;Methods;Monitor;Moods;Neurologic;Neurons;NMR Spectroscopy;Oregon;Outcome;Pathway interactions;Phytochemical;Plant Sources;Plasma;Preparation;public health relevance;Reaction;Reference Standards;Research;Research Project Grants;resilience in aging;Resolution;Role;sleep quality;Spectroscopy, Fourier Transform Infrared;Testing;Thin Layer Chromatography;Triterpenes;United States National Institutes of Health;Visual;Work

PROJECT_TITLE: Botanical Core


NIH_SPENDING_CATS: Aging;Complementary and Integrative Health;Dietary Supplements;Natural Products;Nutrition

PROJECT_TERMS: Achievement;Address;Administrator;Advisory Committees;Biometry;Botanical dietary supplements;Botanicals;Clinical Trials;Collaborations;Communication;cost;Data;data exchange;data management;Database Management Systems;Dedications;design;Discipline;Ensure;faculty mentor;Fees;Fostering;Funding;Goals;graduate student;Grant;Harvest;Health;Information Dissemination;Institution;International;Journals;Manufacturer;meetings;member;Mentors;Mission;Mississippi;multidisciplinary;Natural Products;Naturopathy;Neurologic;Oregon;Postdoctoral Fellow;Principal Investigator;Productivity;Protocols documentation;Publications;quality assurance;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Research Training;resilience in aging;Resources;Role;Science;Services;Shipping;Statistical Data Interpretation;Structure;success;symposium;System;Training Activity;training opportunity;Training Programs;Travel;United States National Institutes of Health;Universities;Update;web site;Work

PROJECT_TITLE: Administrative Core/Structure


NIH_SPENDING_CATS: Cystic Fibrosis;Genetics;Lung;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE This project explores a new hypothesis related to progressive lung inflammation in patients with cystic fibrosis (CF). We will focus on the role of extracellular vesicles as drivers of chronic lung neutrophil reprogramming and investigate newly discovered upstream causative processes and downstream effector pathways. This study will inform therapies for CF and other human diseases associated with intractable neutrophilic lung inflammation.

PI_NAMEs: TIROUVANZIAM, RABINDRA MARIE-JEAN (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Adult;airway inflammation;Animals;autosome;Biogenesis;Bioinformatics;Biology;c-myc Genes;Cells;Chemotactic Factors;Child;Chromatin;Chronic;Citric Acid Cycle;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis infection;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Cytoplasmic Granules;Data;Disease;Drug usage;Epithelium;European;Exocytosis;extracellular vesicles;Functional disorder;Genetic Transcription;Genomics;Goals;HDAC11 gene;Histone Deacetylase Inhibitor;Human;human disease;human model;Hyperactivity;Immunology;immunoregulation;In Vitro;in vivo;Inflammation;inhibitor;innovation;Intervention;Knowledge;large scale production;Leukocytes;Licensing;life span;Link;Liquid substance;Lung;Medicine;Messenger RNA;Metabolic;Methods;Microbe;migration;Mitochondria;Modeling;Mucous body substance;Mus;Mutation;neutrophil;Neutrophil Infiltration;novel;Obstruction;Opportunistic Infections;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Play;Process;Production;Property;Proteins;Proteomics;Publishing;Pulmonary Cystic Fibrosis;Pulmonary Inflammation;Reaction;recruit;Reporting;Research;RNA;Role;Small Interfering RNA;small molecule;Sputum;stem;Surface;targeted treatment;Testing;Therapeutic Intervention;Tissues;tool;transcription factor;transcriptomics;Transfection;Transfer RNA;Untranslated RNA

PROJECT_TITLE: Extracellular vesicle-driven neutrophilic inflammation in cystic fibrosis lungs

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biotechnology;Clinical Research;Infectious Diseases;Nanotechnology;Prevention;Wound Healing and Care

PHR: Surgical site infections (SSIs) alone account for 20% of all healthcare-associated infections (HAIs) and approximately 160,000-300,000 SSIs occur each year in the United States. These infections account for about 8200 death and nearly $3.5-10 billion annually in additional healthcare costs. The application outlines a strategy to develop therapeutic anti-infective wound dressings that improve the host immune response to attack the pathogen on numerous fronts rather than a single front like traditional antibiotics.

PI_NAMEs: XIE, JINGWEI  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: 3-Dimensional;Address;Anti-Infective Agents;Antibiotic Resistance;Antibiotics;antimicrobial;Award;Bacteria;biomaterial compatibility;cathelicidin antimicrobial peptide;Cell Culture Techniques;Cell Proliferation;Cells;Cessation of life;Clinical;Collagen;combat injury;conventional therapy;cost;cytokine;cytotoxicity;Data;Deposition;Development;effective therapy;Encapsulated;Engraftment;ESKAPE pathogens;exosome;Foundations;Funding;Gases;Genes;Goals;Grant;healing;Health Care Costs;healthcare-associated infections;Human;Immune;immune cell infiltrate;Immune response;Immune system;Immunity;immunoregulation;improved;Infection;Infection prevention;Inflammation;Inflammatory;Infrastructure;innovation;Inpatients;Intervention;Investments;keratinocyte;Knowledge;Life;Mass Spectrum Analysis;Measures;Mechanics;Membrane;Mesenchymal;Methods;MicroRNAs;migration;miRNA expression profiling;Modeling;Morphology;mouse model;Multi-Drug Resistance;Mus;nanofiber;Nanofiber Scaffold;nanomaterials;Natural Immunity;neovascularization;next generation;novel;novel strategies;novel therapeutics;Operating Rooms;Operative Surgical Procedures;overexpression;Paper;pathogen;Patients;Peptides;Play;Postoperative Period;preclinical study;prevent;Primates;Productivity;Property;Proteins;Proteomics;Publishing;readmission rates;Resistance development;response;risk minimization;scaffold;Skin;skin wound;Speed;Staphylococcus aureus;Sterile coverings;Sterility;Structure;Surgical incisions;Surgical Wound Infection;Techniques;Testing;Therapeutic;Topical application;Transfection;Transgenic Mice;two-dimensional;United States;Virulence;Vitamin D;Work;wound dressing;wound healing;Wound Infection;Wound models

PROJECT_TITLE: Nanofiber-based Delivery of Combined Immune-modulating Compounds to Minimize Infection and Enhance Wound Healing

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Many female and gender diverse autistic people are late-, mis- or never diagnosed, putting them at greater risk for depression, anxiety and self-harm. We will tackle this problem and develop a tool to speed up diagnosis. This will help autistic people to get the right help at the right time, and improve quality of life.

PI_NAMEs: JACK, ALLISON ELIZABETH;KENWORTHY, LAUREN ;PELPHREY, KEVIN A (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Acceleration;Adolescent;adolescent with autism spectrum disorder;Adult;adult with autism spectrum disorder;Advocate;Age;Anxiety;Area;Artificial Intelligence;artificial intelligence method;assigned female at birth;Autism Diagnosis;autism spectrum disorder;autism symptoms;autistic;Behavioral;biobehavior;Biological Markers;biomarker identification;Characteristics;cisgender;Classification;clinical diagnosis;clinical practice;Cognitive;cohort;Collaborations;Communities;community engagement;comorbidity;contextual factors;Data;Data Set;Databases;deep learning;Development;Diagnosis;Diagnostic;Early Diagnosis;Elements;Equity;ethnoracial;Examinations and Diagnoses;executive function;Exhibits;experience;Female;Gender;gender diverse;gender diversity;Gender Identity;General Population;Goals;imaging modality;improved;improved outcome;indexing;Individual;individuals with autism spectrum disorder;innovation;Intelligence;interest;Intervention;Interview;Investigation;Learning;Link;Lived experience;Longitudinal cohort;Magnetic Resonance Imaging;male;Measures;Mental Depression;Mental Health;Methods;Modeling;Moods;Motivation;multimodal neuroimaging;neuroimaging;nonbinary;novel;Outcome;Parents;Participant;Patient Self-Report;Pattern;Performance;Personal Satisfaction;personalized approach;Persons;Phenotype;Play;Population;Populations at Risk;Post-Traumatic Stress Disorders;Prevention;Process;psychiatric comorbidity;Quality of life;recruit;repetitive behavior;Reporting;Research;Research Personnel;Rest;Risk;Risk Factors;Sampling;screening;Screening procedure;Self Assessment;Self-Injurious Behavior;sex;sex assigned;Sex Differences;social;spatiotemporal;Speed;Subgroup;suicidal;Symptoms;theories;Time;tool;Training;trend;Validation;women versus men;women's diagnosis;Work;young adult;Youth

PROJECT_TITLE: Autism Center of Excellence Network: Neurodevelopmental Biomarkers of Late Diagnosis in Female and Gender Diverse Autism


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative The development of ligands that modify epigenetic marks has become an active area of investigation within academia and industry across diverse therapy areas. However, the great promise of this effort has yet to be fully realized due to the complexity of the epigenetic chromatin landscape. In this proposal we describe proximity proteomics methods for mechanism of action elucidation within epigenetic drug discovery, providing a new vector for small molecule screening and analysis.

PI_NAMEs: SEATH, CIARAN  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Academia;Area;Binding Proteins;Biology;Biotin;c-myc Genes;carbene;catalyst;cell type;Chromatin;chromatin remodeling;demethylation;design;Development;Diazomethane;Disease;Dissociation;drug candidate;drug development;drug discovery;drug market;Energy Transfer;epigenetic drug;Epigenetic Process;epigenetic regulation;Gene Expression;Gene Expression Regulation;Genetic Transcription;Health;Human;Hydrogen Bonding;improved;Incubated;Industry;inhibitor;intein;Investigation;Investments;Iridium;irradiation;Label;Ligands;Lysine;Measures;Methods;Molecular;Monitor;Nitrogen;Nuclear;Phenotype;Population;Post-Translational Protein Processing;Process;Protein Isoforms;Proteins;Proteomics;Radial;Regulation;research clinical testing;RNA Splicing;Role;screening;small molecule;success;Therapeutic Intervention;Time;tool;vector;Visible Radiation

PROJECT_TITLE: Photoproximity labeling as a tool for epigenetic drug discovery

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PHR: NARRATIVE The sequencing of the human genome was heralded as the end of the search for genes; however, the discovery of thousands of microproteins in the last decade revealed a blind spot for our smallest proteins. This application focuses on characterizing the biological roles of microproteins in cells and in vivo and developing approaches for regulating them that can be utilized to develop new drugs that target microproteins.

PI_NAMEs: O'SHEA, CLODAGH ;SAGHATELIAN, ALAN  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Acceleration;Adopted;Agonist;Algorithms;Amino Acid Sequence;Amino Acids;Antibodies;Area;Base Pairing;Biochemical;Biological;biological adaptation to stress;Biological Process;Biological Products;Biology;Catalogs;Cell Line;Cells;cis acting element;Code;Disease;DNA;DNA Repair;DNA Sequence;drug development;Ecosystem;endoplasmic reticulum stress;Essential Genes;frontier;G-Protein-Coupled Receptors;gene discovery;Gene Family;Generations;Genes;Genetically Engineered Mouse;Genome;genomic platform;Goals;Human;human disease;Human Genome;Human Genome Project;human genome sequencing;improved;in vivo;Insulin;Knowledge;Learning;Length;Link;Malignant Neoplasms;mammalian genome;Medicine;Messenger RNA;Mitochondria;Molecular Biology;Molecular Medicine;new therapeutic target;novel;Open Reading Frames;Peptides;Physiology;Protein Databases;protein protein interaction;Protein Secretion;Proteins;Proteolysis;Proteomics;Protocols documentation;Reagent;receptor;Retinal blind spot;Ribosomes;RNA Sequences;Role;Scientist;small molecule;small molecule inhibitor;Structure;Syndrome;Technology;Therapeutic;therapeutic development;Tissues;Translating;Translational Regulation;Translations;Work

PROJECT_TITLE: The Discovery of Human Peptide Encoding Genes

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Aging;Cancer;Genetics;Hematology;Infectious Diseases;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Inflammation is important for innate immune responses to infection but also can cause blood disorders including bone marrow failure, aplastic anemia, myelodysplastic syndrome, and clonal hematopoiesis. The goal of this project is to delineate the mechanisms by which inflammatory cytokine signaling drives hematopoietic stem cell differentiation, depletion, clonal competition, and immunologic reprogramming with the long-term goal of revealing therapeutic targets to support healthy blood production throughout life.

PI_NAMEs: KING, KATHERINE YUDEH (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: age-related disease;aging population;Aplastic Anemia;Bacterial Adhesins;Blood;Blood Cells;Bone Marrow;Bone marrow failure;bone marrow failure syndrome;Cardiovascular Diseases;Cell Communication;Cell surface;Cells;Chronic;Cytokine Signaling;Disease;DNMT3a;Dysmyelopoietic Syndromes;Effector Cell;Elderly;Epigenetic Process;Explosion;Exposure to;Genetic Transcription;Goals;Heart Diseases;Hematologic Neoplasms;Hematological Disease;Hematology;Hematopoiesis;hematopoietic differentiation;hematopoietic stem cell differentiation;hematopoietic stem cell quiescence;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Immune;immune function;Immune system;Immunity;Immunologics;Impairment;Infection;Inflammation;Inflammation Mediators;Inflammatory;Innate Immune Response;insight;Interferon Type II;Knowledge;leukemia;Life;Link;Longevity;Malignant Neoplasms;Mediating;Molecular;mortality;Mutation;Mycobacterium Infections;Pancytopenia;Patients;Physiological;Play;preservation;Production;Productivity;programs;Regulation;Research;Risk Factors;Role;stem cell exhaustion;stem cell function;Stem cell transplant;Stress;Stroke;therapeutic target;Time;transcription factor;Work

PROJECT_TITLE: Impact of Infection and Inflammation on Primitive Hematopoiesis


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biomedical Imaging;Cancer;Emerging Infectious Diseases;Infectious Diseases;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Project Narrative  A cell is not a static bag of molecules. By “watching the orchestra of molecules” in real space and time inside a living system, this proposal aims to push the boundary of nonlinear vibrational spectroscopic imaging platforms in order to unveil the hidden signatures that underlie initiation or progression of human diseases.

PI_NAMEs: CHENG, JI-XIN  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Action Potentials;Antimicrobial Resistance;Anus;Biological;Biology;cancer cell;cell behavior;Cells;Cellular Metabolic Process;Chemicals;Chemistry;chromophore;Collaborations;Communicable Diseases;detection sensitivity;Development;Diagnosis;Disseminated Malignant Neoplasm;drug resistant bacteria;Engineering;Entrepreneurship;Exposure to;Goals;human disease;Image;imaging platform;Imaging technology;in vivo;invention;Label;Life;Malignant Neoplasms;Maps;Medicine;Membrane;Metabolic;Metabolism;microorganism;Microscopy;Mission;molecular assembly/self assembly;Molecular Profiling;neural;Neurons;Optics;Organism;Penetration;Pharmacotherapy;photolysis;Photons;Physics;programs;Property;Research;Resolution;response;Science;single molecule;spectroscopic imaging;Speed;stem cells;stemness;Stress;Technology;Time;Tissues;tumor progression;voltage

PROJECT_TITLE: Vibrational Spectroscopic Imaging to Unveil Hidden Signatures in Living Systems

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Obesity;Pediatric;Prevention;Social Determinants of Health;Violence Research

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE Adverse childhood experiences (ACEs) are a risk factor for childhood obesity, though the ACEs-obesity relationship is not well understood. The impact of neighborhood environment is particularly understudied, despite its influence on both ACEs and obesity risk. This study will examine the relationship between neighborhood environment, ACEs, and childhood obesity in order to inform targeted approaches to reducing obesity for the millions of children who experience ACEs.

PI_NAMEs: SCHROEDER, KRISTA  (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: adult obesity;adverse childhood events;American;Behavior;Behavioral;career;career development;Caregivers;Child;Child Abuse and Neglect;Child Health;Childhood;Chronic;clinical practice;Collaborations;Complex;Crime;Data;Development;Development Plans;Disparity;Domestic Violence;Education;Environment;ethnic minority;Exercise;experience;Family;Family member;foster care;Functional disorder;Funding;Geography;Goals;Health;Health behavior change;health care availability;health disparity;Health Personnel;Health Policy;Household;Imprisonment;improved;Incidence;indexing;Individual;Intervention;K-Series Research Career Programs;Knowledge;Low income;Low Income Population;Mentorship;Methodology;Methods;National Institute of Child Health and Human Development;Neighborhoods;New York City;novel;novel strategies;Nurses;obese person;Obesity;Obesity Epidemic;obesity in children;obesity risk;obesity treatment;Outcome;Pathway interactions;Philadelphia;physical conditioning;Physiological;Policies;Population;Poverty;Prevalence;programs;psychologic;Psychometrics;psychosocial;racial minority;Racial Segregation;Randomized;Research;Risk;Risk Factors;Schools;Science;Scientist;screening;Sexual abuse;skills;social;social health determinants;Statistical Methods;statistics;Stress;success;Sum;System;Teacher Professional Development;Testing;Training;United States;United States National Institutes of Health;Universities;Validation;violent crime

PROJECT_TITLE: A Novel Approach to Disentangling the Relationship Between Neighborhood Environment, Adverse Childhood Experiences, and Childhood Obesity

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Data Science;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_NAME: ALLEN INSTITUTE

PHR: Project Narrative The development of a systematic census of cell types in mammalian species is a critical priority for the BRAIN Initiative Cell Atlas Network Program (BICAN) towards understanding human brain function in health and disease. BICAN scientists will need to collaboratively share, curate, and annotate brain cell types taxonomies produced from their data, and public researchers will be eager to understand BICAN findings, map their data against BICAN taxonomies, and contribute their own findings to the bolas of community knowledge. This proposal is to develop an extensible Brain Cell Knowledge Base (BCKB) to support BICAN’s development of a multimodal, multi-species brain cell atlas and utilization of that atlas as an open community resource for advancing knowledge of the brain.

PI_NAMEs: GHOSH, SATRAJIT SUJIT;HAWRYLYCZ, MICHAEL ;MUFTI, SHOAIB  (contact);NG, LYDIA LUP-MING

PROGRAM_OFFICER_NAME: YAO, YONG

PROJECT_TERMS: 3-Dimensional;Acceleration;Adult;Anatomy;Atlases;Brain;brain cell;BRAIN initiative;cell type;Cells;Censuses;Classification;Communities;community research;Data;data archive;data integration;data modeling;Data Set;data visualization;Derivation procedure;Development;Dimensions;Disease;Disparate;Ecosystem;Educational workshop;epigenomics;Event;Evolution;FAIR principles;Feedback;flexibility;Fostering;Generations;Germ Cells;Goals;Graph;Health;Human;improved;Information Resources;Infrastructure;Ingestion;Knowledge;knowledge base;knowledge graph;knowledge integration;Libraries;life span;Link;Machine Learning;Maps;Modality;Molecular;Morphology;Motor Cortex;multimodal data;multimodality;Mus;Neurosciences;nonhuman primate;Ontology;programs;Protocols documentation;prototype;Publications;Pythons;Research Personnel;Resources;Science;Scientist;Source;Standardization;Structure;Taxonomy;tool;Training;transcriptomics;Transgenic Organisms;trustworthiness;Update;Viral;Visualization;web app;Work

PROJECT_TITLE: An extensible brain knowledge base and toolset spanning modalities for multi-species data-driven cell types


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: This project aims to make a broad impact upon the neuroimaging community by extending, solidifying and disseminating a set of universal JSON-based neuroimaging data exchange format specifications, and readily enable the ability in both local and cloud-based data analysis pipelines to handle large, complex neuroimaging datasets via widely used NoSQL database technology. The success of this project is expected to greatly improve our ability to integrate, manipulate, reuse and disseminate existing public and NIH-funded neuroimaging datasets, accommodate fast-growing neuroimaging data in both size and complexity, and modernize widely used neuroimaging data analysis pipelines to be ready for automation, large-scale data processing, easy data exchange, and backward-compatible future extensions.

PI_NAMEs: FANG, QIANQIAN  (contact)

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TERMS: Address;Adopted;Adoption;Archives;Automation;Back;cloud based;Collaborations;Communities;Complex;Computer software;computerized data processing;Data;Data Analyses;data analysis pipeline;data dissemination;data exchange;Data Files;data format;data integration;data management;data platform;data resource;Data Set;data sharing;Data Storage and Retrieval;Databases;Documentation;Educational workshop;Electroencephalography;file format;flexibility;forging;Foundations;functional near infrared spectroscopy;Funding;Future;Growth;hackathon;Human;Image;improved;Industry;Information Technology;large datasets;large scale data;Letters;Libraries;light weight;Linux;Magnetic Resonance Imaging;Maintenance;Modernization;multimodality;neuroimaging;Neurosciences;next generation;Online Systems;open source;open source tool;Output;Performance;Privatization;prototype;Publishing;Readability;Records;Reproducibility;Research;response;scale up;Series;software development;Solid;Specific qualifier value;Standardization;success;Technology;Text;tool;Training;United States National Institutes of Health;Validation;Vision;Writing

PROJECT_TITLE: NeuroJSON - A Scalable, Searchable and Verifiable Neuroimaging Data Platform


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Hematology;Nanotechnology;Regenerative Medicine;Wound Healing and Care

ORG_CITY: ARKADELPHIA

ORG_DEPT: CHEMISTRY

ORG_NAME: OUACHITA BAPTIST UNIVERSITY

ORG_STATE: AR

PHR: PROJECT NARRATIVE The goal of this proposal is to develop degradable, biomimetic fiber mats that help stop bleeding. Successful completion of this project may provide new affordable and effective material to be used in emergency settings.

PI_NAMEs: HAMILTON, SHARON K (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: 3T3 Cells;Address;Amides;analog;Architecture;Biocompatible Materials;Biological Assay;biomaterial compatibility;Biomimetics;Biopolymers;caprolactone;career;Cell Culture Techniques;Chitosan;Coagulation Process;Collagen;Complement;Complex;cost;Coupled;Coupling;Debridement;Development;Electrospinning;emergency settings;Environment;Enzymes;Evaluation;Evolution;Excision;Exhibits;experience;Fiber;functional group;Future;Goals;graduate school;Hemorrhage;Hemostatic Agents;Hemostatic function;Histologic;Image;In Vitro;in vivo;in vivo evaluation;innovation;Internet;Knowledge;Laboratories;light weight;liver injury;macromolecule;Modeling;Modernization;monomer;Mus;nanofiber;Nanofiber Scaffold;NIH 3T3 Cells;novel;Organic Chemistry;Patients;Physiological;polycaprolactone;Polyesters;Polymers;prevent;Property;Publishing;Reaction;regenerative;regenerative treatment;Research;response;scaffold;Second Look Surgery;skills;Students;subcutaneous;symposium;Testing;Thrombin;Time;tissue regeneration;Tissues;undergraduate student;Work;wound dressing;wound healing;Wound models

PROJECT_TITLE: Development of Degradable Fibers with Hemostatic Properties


NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Following traumatic brain injury (TBI), patients often develop persistent disabilities, and specific problems with memory underlie much of the long-term adverse outcomes associated with serious brain injury. We have recently demonstrated that the some of the spontaneous recovery that occurs after TBI is due to generation of new neurons within the hippocampus, the part of the brain that mediates memory formation. We have also demonstrated that ApoE, a gene long associated with outcome following TBI, directs hippocampal development and the purpose of this project is to determine how ApoE regulates injury-induced neurogenesis.

PI_NAMEs: KERNIE, STEVEN GERARD (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Activities of Daily Living;Address;Adult;adverse outcome;Affect;Alzheimer's Disease;American;ApoE knockout mouse;Apolipoprotein E;apolipoprotein E-4;Area;Astrocytes;Attenuated;Behavioral;Behavioral Assay;Binding;Brain;brain dysfunction;Brain Injuries;Cells;Chronic disability;Cognition;cognitive function;cognitive recovery;Communication;Confusion;Contralateral;cost;Cues;dentate gyrus;Development;disability;Dominant-Negative Mutation;Emotional Stability;Gene Activation;Generations;Genes;Genetic;genetic signature;Goals;Headache;Hippocampus;Human;Immediate-Early Genes;Impaired cognition;Impairment;Induced Neurons;injured;Injury;injury recovery;Ipsilateral;Knock-in Mouse;Maps;Mediating;Memory;memory acquisition;Memory Loss;Methods;Microglia;Morbidity - disease rate;mouse model;Mus;Mutation;Neurodegenerative Disorders;neurogenesis;neuron development;Neurons;newborn neuron;Outcome;outcome prediction;Pattern;Population;Process;Protein Isoforms;Public Health;Publishing;Recovery;Regulation;Reporter;response to injury;Rest;Role;Severities;Side;Signal Transduction;TBI Patients;Testing;therapeutic target;Time;transcriptome sequencing;translational study;Traumatic Brain Injury;TREM2 gene;United States;Variant;Viral

PROJECT_TITLE: The Role of ApoE in Injury-Induced Neurogenesis

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Cancer

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Advances in cancer medicine rely on innovative basic, translational and clinical research. This University of Pennsylvania Cancer Research Training Program strives to recruit and train the next generation of clinician scientists, providing them with the skills to make discoveries with potential for direct translation to patient care.

PI_NAMEs: HUNGER, STEPHEN PATRICK (contact);MAILLARD, IVAN

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: NCI Center for Cancer Research;Training Programs

PROJECT_TITLE: Cancer Center Research Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The Hippo pathway plays a major role in cell growth, tissue homeostasis, and organ size, and is frequently altered in human cancer. The main goal of this proposal is to elucidate the molecular mechanisms of Hippo pathway regulation, particularly the role of phosphoinositides. Completion of this project will not only address fundamental questions in Hippo regulation, but also provide valuable leads for therapeutic intervention of the Hippo pathway for cancer treatment.

PI_NAMEs: BROWN, JOAN HELLER (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Address;Binding;cancer therapy;cell growth;Cell membrane;Cells;Data;Development;G-Protein-Coupled Receptors;Genetic Transcription;Goals;Growth Factor;Homeostasis;Human;human disease;Malignant Neoplasms;Mediating;Membrane;Modeling;Molecular;Natural Compound;Neurofibromin 2;novel;Organ Size;Osmosis;Pathway interactions;Phosphatidylinositol Phosphates;Phosphatidylinositol Transfer Protein;Phosphatidylinositols;Phosphorylation;Phosphotransferases;Play;protein function;Regulation;Role;Sampling;screening;sensor;Signal Pathway;Signal Transduction;Site;small molecule;Stress;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Intervention;Tissues;tumor

PROJECT_TITLE: Protein phosphorylation and growth factor function

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Most colorectal cancer patients have microsatellite stable phenotype (immune cold) tumors with poor T cell infiltration. This pilot study will establish that tumor-enriched metabolites influence immunosuppressive macrophage abundance in colorectal cancer. The results from this study will provide insights into metabolites that can be targeted to improve anti-tumor immune responses in colorectal cancer.

PI_NAMEs: SUBRAMANIAN, SUBBAYA  (contact)

PROGRAM_OFFICER_NAME: DUGLAS TABOR, YVONNE

PROJECT_TERMS: Accounting;Affect;anti-tumor immune response;Aryl Hydrocarbon Receptor;Biological Assay;cancer type;Cessation of life;Characteristics;checkpoint therapy;Clinical;Coculture Techniques;Colon;colon cancer patients;Colorectal Cancer;Complex;Culture Media;cytokine;Environment;Essential Amino Acids;Exposure to;Flow Cytometry;Homeostasis;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;immunogenic;immunosuppressive macrophages;improved;In Vitro;Infiltration;insight;interest;Intervention;Investigation;Kynurenine;Macrophage;Malignant Neoplasms;Measures;Metabolic;metabolomics;microbial;microbiome;microbiota;Microsatellite Instability;Microsatellite Repeats;Modeling;monocyte;Myeloid Cells;Normal tissue morphology;novel;Organoids;pathogenic bacteria;Pathologic;patient population;Patient-Focused Outcomes;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Phenylalanine;Pilot Projects;Prognostic Marker;Receptor Signaling;Regulation;Sampling;screening;T cell infiltration;Tissues;TNF gene;Transforming Growth Factor beta;Tryptophan;tumor;tumor microenvironment;Tumor Tissue;Undifferentiated;United States

PROJECT_TITLE: Metabolites regulating macrophage function in colorectal cancer


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Social learning is the foundation for speech, music and athletics but full mastery of these complex behaviors requires the fluent coordination of learned and innate motor programs. The goal of this proposal is to test the hypothesis that a neural circuit comprising a midbrain dopamine cell group and its cortical and subcortical projections is crucial to social learning and the coordination of learned and innate motor programs.

PI_NAMEs: MOONEY, RICHARD D (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TITLE: Mechanisms for internally and externally guided sensorimotor learning

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

ORG_STATE: NJ

PHR: Candida glabrata is a major fungal pathogen causing opportunistic, life-threatening infections in individuals with reduced immunity, such as transplant patients, those with HIV, premature infants, and, recently, COVID-19 patients. Among fungi causing invasive fungal infections, C. glabrata accounts for the greatest total incidence of drug resistance, with the highest resistance to echinocandins, a first-line antifungal drug class. In this proposal we will elucidate the determinants of C. glabrata echinocandin tolerance and resistance specifically in the physiologically relevant host niches, such as macrophages and the gastrointestinal tract.

PI_NAMEs: PERLIN, DAVID S (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Anabolism;anti-fungal agents;Azoles;Candida;Candida albicans;Candida auris;Candida glabrata;Candidate Disease Gene;Candidiasis;Caspofungin;Cells;Cessation of life;Clinical;clinically relevant;Comet Assay;Complex;COVID-19 patient;design;DNA;Dose;drug action;Drug Exposure;Drug Metabolic Detoxication;Drug resistance;Drug Targeting;Drug Tolerance;echinocandin resistance;Electron Spin Resonance Spectroscopy;Electrons;Environment;Epidemiology;Evolution;experimental study;Exposure to;fitness;fungus;gastrointestinal;Gastrointestinal tract structure;Genes;Genetic;Genetic Determinism;glucan synthase;Grant;Health;Heritability;HIV;Immunity;In Vitro;in vivo;Incidence;Individual;Infection;inhibitor;insight;Intervention;Knowledge;Libraries;Life;Light;Macrophage;Malaria;Mass Spectrum Analysis;Measures;Modeling;multidisciplinary;Mus;mutant;Mutation;Mycoses;next generation;Oxidants;pathogen;pathogenic fungus;Pathway interactions;Patients;Pharmaceutical Preparations;Physiological;Population;Predisposition;Premature Infant;prevent;Proteins;Reactive Oxygen Species;Reporter;Resistance;resistance mutation;Resistant candida;response;Role;Route;screening;Source;Sphingolipids;Survivors;Transplant Recipients

PROJECT_TITLE: Critical Factors Influencing Echinocandin Resistance in Candida glabrata

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIRT-J(01)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: This project will investigate the role of noise in the vestibular system, and in particular its effects on the variability (precision) of vestibular-mediated behaviors. We will study vestibular precision in normal subjects and patients with peripheral vestibular damage, and will investigate its potential plasticity. The goals are to develop a better understanding of the role played by noise in the vestibular system in normal and pathologic populations, and to determine if the brain can learn to improve signal recognition within its inherently noisy neural environment, which would result in improved behavioral precision.

PI_NAMEs: KARMALI, FAISAL  (contact);LEWIS, RICHARD F

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Ablation;Acoustic Neuroma;Affect;Age;Attention;Bayesian Modeling;Bayesian Prediction;Behavior;Behavioral;behavioral response;Biological Assay;Brain;Characteristics;Clinical;Compensation;Cues;Data;disability;Dizziness;Ear;Environment;Excision;experience;Exposure to;Eye Movements;Fatigue;Fiber;Functional disorder;Goals;Head;human subject;improved;Learning;Lesion;Measurement;Measures;Mediating;Methods;Modality;Morbidity - disease rate;Motion;Motor;Motor Pathways;Nerve;nerve damage;neural;Noise;novel;oculomotor;Operative Surgical Procedures;otoconia;Outcome;Outcome Measure;Pathologic;Pathway interactions;Patient Education;Patients;Perception;Peripheral;Physiology;Play;Population;Postoperative Period;predict clinical outcome;Predictive Value;Process;Research;Residual state;response;Role;Rotation;secondary outcome;sensor;Sensory;Signal Transduction;Source;Stimulus;symptomatology;Symptoms;Testing;Theoretical model;Time;Training;Translations;tumor;Validation;Variant;Vestibular function;Vestibular Nerve;vestibular system;vestibulo-ocular reflex;Visual;Work

PROJECT_TITLE: Vestibular Precision: Physiology and Pathophysiology

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]