ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: HOBOKEN

ORG_NAME: THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY

PHR: NARRATIVE The key to successfully treat prevalent skeletal disorders such as osteoporosis relies on understanding changes in the tissue associated with the observed reduced bone quality and increased fracture risk. Here, we propose a unique approach to investigate in clinical biopsies the complex relationship between multiple bone nanoscale compositional properties and typical histopathological and morphometric findings of osteoporotic bones. This innovative project will reveal valuable insights into the nanoscale origins of impaired bone health, contributing to elucidating osteoporosis pathogenesis and to inform future clinical studies into new therapeutic tissue targets to improve bone quality.

PI_NAMEs: QUERIDO, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: 3-Dimensional;Address;age related changes;aging population;artificial neural network;Biopsy;bone;Bone Density;bone fragility;bone health;bone quality;bone strength;Bone Tissue;Clinical;Clinical assessments;Clinical Management;Clinical Research;Collagen;Collagen Fibril;Complex;crystallinity;Data;Data Set;deep learning;Diagnosis;Disease;Elements;Evaluation;Fracture;fracture risk;Future;Goals;Heterogeneity;Histologic;Image;imaging system;Impairment;improved;Incidence;Individual;infrared spectroscopy;innovation;insight;Knowledge;Least-Squares Analysis;Machine Learning;machine learning method;markov model;meter;microCT;mineralization;Minerals;Modeling;Morphology;morphometry;nanoscale;Nature;novel therapeutics;Optics;Osteon;Osteoporosis;osteoporotic bone;Outcome;Outcomes Research;Pathogenesis;Performance;Persons;Pharmacotherapy;Play;Polishes;Polymethyl Methacrylate;Property;Public Health;recurrent neural network;Research;research study;Resolution;Role;Sampling;Scanning Electron Microscopy;skeletal disorder;Specificity;Spectroscopy, Fourier Transform Infrared;Standard Preparations;stoichiometry;Structure;submicron;Techniques;Tissues;Validation;X ray spectroscopy

PROJECT_TITLE: Multifactorial contribution of bone nanoscale composition to tissue quality in osteoporosis

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: NEW YORK GENOME CENTER

ORG_STATE: NY

PI_NAMEs: RIZAJ, KHULANGOO  (contact)

PROJECT_TERMS: Area;Atlases;Award;Biological Assay;Biomedical Research;BRAIN initiative;Cancer Center;cancer genomics;Cell Nucleus;Cells;Contracts;Data;deep sequencing;DNA Methylation;DNA Sequencing Facility;experience;Funding;Genetic Diseases;Genome;genome sequencing;genome wide methylation;genomic data;Genomics;Grant;Heart Diseases;Hematological Disease;human tissue;Libraries;Lung Diseases;Mosaicism;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;New York;Process;programs;Resources;Risk Factors;RNA;Sampling;single cell genomics;Sleep Disorders;Somatic Mutation;Technology;Trans-Omics for Precision Medicine;transcriptome sequencing;transcriptomics;tumor;United States National Institutes of Health;whole genome

PROJECT_TITLE: NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED) FOR THE CENTRALIZED OMICS RESOURCE (CORE) - RNA-SEQ - 2024 TASK ORDER


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PI_NAMEs: ECONOMY, IRENE  (contact)

PROJECT_TERMS: absorption;Acceleration;Affinity;Antibodies;Area;ATAC-seq;Biological Assay;Biological Process;Biological Sciences;Cardiovascular Diseases;Cell Nucleus;Cells;cost;Cost Savings;cytokine;Data;Detection;Drug Targeting;Epitopes;Excision;Exhibits;falls;Funding;genome-wide;Inflammation;instrument;large scale data;Mass Spectrum Analysis;Measurement;Measures;Methods;multiple omics;National Heart, Lung, and Blood Institute;Peptides;Phenotype;Plasma;Plasma Proteins;Post-Translational Protein Processing;protein complex;Protein Databases;protein profiling;Proteins;Proteome;Proteomics;Resources;RNA;Sampling;Signal Transduction;single nucleus RNA-sequencing;Small Nuclear RNA;Specificity;Technology;Therapeutic;Trans-Omics for Precision Medicine;transcriptome sequencing;Trypsin

PROJECT_TITLE: NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED) FOR THE CENTRALIZED OMICS RESOURCE (CORE) - TASK AREAS 4 AND 5 - 2024 TASK ORDER


ADMINISTERING_IC: MD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Project Narrative The goal is to understand how social media can be used as tool to promote minority youth mental health and resilience in the context of climate change. We will explore minority youth experiences with climate activism on social media and co-design a climate social media campaign to build capacity and resilience of minority youth.

PI_NAMEs: PARNES, MCKENNA  (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TITLE: Youth climate activism on social media: Building psychosocial resilienceamong minority youth


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: COLUMBUS

ORG_NAME: BATTELLE CENTERS/PUB HLTH RES & EVALUATN

ORG_STATE: OH

PI_NAMEs: PANG, KAITLIN  (contact)

PROJECT_TERMS: assay development;Biological;biological development;Biological Products;Biological Response Modifier Therapy;Contracts;Development;Dose;Drug Interactions;Drug Kinetics;Formulation;Funding;In Vitro;Industry;Investigational Drugs;manufacture;Nervous System Disorder;Neurosciences;Peptides;Pharmaceutical Preparations;Phase I Clinical Trials;programs;Research Personnel;Services;Toxic effect;Toxicology;United States National Institutes of Health

PROJECT_TITLE: NON-GLP DOSE-RANGE FINDING AND GLP TOXICITY STUDIES AND IN VITRO DRUG-DRUG INTERACTION STUDIES FOR A SMALL PEPTIDE


NIH_SPENDING_CATS: Neurosciences

PI_NAMEs: GRIDLEY, JAMES  (contact)

PROJECT_TERMS: Biologic Development;Biological Assay;Contracts;Development;Dose;drug development;Funding;Industry;Investigational Drugs;Nervous System Disorder;Neurosciences;Phase I Clinical Trials;programs;Research Personnel;Services;therapeutic development;Toxicology;United States National Institutes of Health;Validation

PROJECT_TITLE: VALIDATION OF BIOANALYTICAL ASSAYS AND IND- ENABLING GLP PD/PK TOXICOLOGY STUDIES


NIH_SPENDING_CATS: Biotechnology;Duchenne/ Becker Muscular Dystrophy;Muscular Dystrophy;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

ORG_STATE: MD

PI_NAMEs: REDDY, KUMAR  (contact)

PROJECT_TERMS: Antibodies;Biological Products;candidate identification;Drug Kinetics;Duchenne muscular dystrophy;Funding;Investigational Drugs;lead candidate;manufacture;Monoclonal Antibodies;National Institute of Neurological Disorders and Stroke;programs;Toxicology

PROJECT_TITLE: LEAD CANDIDATE IDENTIFICATION PK AND TOXICOLOGY STUDIES FOR ANTIBODY PROJECT IN BLUEPRINT NEUROTHERAPEUTICS (BPN) BIOLOGICS PROGRAM


NIH_SPENDING_CATS: Clinical Research;Tobacco;Tobacco Smoke and Health

ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

PI_NAMEs: CARUSI, CHARLES  (contact)

PROJECT_TERMS: Country;Food;Health;Longitudinal Studies;Performance;Persons;Pharmaceutical Preparations;Population Assessment of Tobacco and Health;Research;Tobacco;Tobacco use;United States;United States National Institutes of Health

PROJECT_TITLE: POPULATION ASSESSMENT OF TOBACCO AND HEALTH (PATH) STUDY PERIOD OF PERFORMANCE: 02/01/2024 - 01/31/2029


ORG_NAME: UNIVERSITY OF WASHINGTON

PI_NAMEs: RHODES, CAROL  (contact)

PROJECT_TERMS: catalyst;Cells;Contractor;Data;database of Genotypes and Phenotypes;Databases;Development;Disease;DNA Methylation;functional genomics;Funding;genome sequencing;genomic data;Goals;Heart;Hematological Disease;Lung;Multiomic Data;National Heart, Lung, and Blood Institute;Phase;precision medicine;Process;programs;Research Personnel;Resolution;Resources;Sleep Disorders;Trans-Omics for Precision Medicine;whole genome

PROJECT_TITLE: NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED) FOR THE CENTRALIZED OMICS RESOURCE (CORE) - DNA METHYLATION - 2024 TASK ORDER


ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PI_NAMEs: MURPHY, BRIDGET  (contact)

PROJECT_TERMS: Alleles;Alternative Splicing;Area;cohort;Communities;CpG Islands;Data;data repository;DNA Methylation;Enhancers;experience;Genes;genome sequencing;Genomics;Genotype;improved;Individual;instrument;Laboratories;Learning;Measures;member;Metabolic;metabolomics;Methods;Methylation;National Heart, Lung, and Blood Institute;next generation sequencing;novel;Pattern;Process;Productivity;programs;Proteomics;Quality Control;Research Personnel;Resources;response;RNA Sequences;Sampling;Science;Specificity;Trans-Omics for Precision Medicine;Transcript;transcriptome;transcriptome sequencing;whole genome

PROJECT_TITLE: NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED) FOR THE CENTRALIZED OMICS RESOURCE (CORE) - TASK AREAS 2, 3, AND 4 - 2024 TASK ORDER


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative In this proposal, our interdisciplinary team proposes to use novel approaches and innovative combinations of data to galvanize the use of EHR networks and population based cohorts to advance EHR-based risk predictions for 1) population level inference; 2) making individualized predictions of absolute risk, and 3) improving reproducibility and cross-site validation. We will predict risk of subsequent incident cardiovascular disease (CVD) in older patients (age 50 and older) with type 2 diabetes (T2DM).

PI_NAMEs: ZHONG, HUA JUDY (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TITLE: EHR-based vs population-based CVD risk predictions for older patients with diabetes

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_NAME: NATIONAL CANCER INSTITUTE

PROJECT_TERMS: Agreement;cancer survival;Cessation of life;Consultations;Contractor;Databases;Epidemiology;Health;Human;Individual;interest;neoplasm registry;Participant;Persons;Registries;Reporting;Research;SEER Program;Services;statistics;Study Subject;Update;Vital Status;Writing

PROJECT_TITLE: SSA: SEER Related Vital Status


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Agreement;cancer health disparity;Cities;Country;Data;Data Linkages;Immigration;Individual;Monitor;National Cancer Institute;Records;Research;Security;statistics;United States;United States National Institutes of Health;United States Social Security Administration

PROJECT_TITLE: SSA SEER Birthplace Data Linkage


PROJECT_TITLE: Technical Support for Surveillance, Epidemiology, and End Results (SEER)-Medicare Health Outcomes Survey (MHOS) Data Set


NIH_SPENDING_CATS: Cancer;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PROJECT_TITLE: Census Bureau:  Estimates of Resident Population for Counties


PROJECT_TERMS: Architecture;Caliber;Contractor;Contracts;Databases;Development;Division of Cancer Control and Population Sciences;Grant;Informatics;Information Systems;Information Technology;Maintenance;operation;Research;Services;Strategic Planning

PROJECT_TITLE: DOI: Calibre Database Support/Information Technology Services and Support (ITSS)


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Project Narrative My major research focus is to understand the fundamental mechanisms of gene regulation and function in the development of cardiovascular disease, a major health burden for our veterans. Our overarching goals are to translate the findings into identification of novel molecular targets and strategies for prevention and intervention of cardiovascular disease. With the ongoing collaboration with physician scientists and basic scientists at the Birmingham VA medical center and UAB, our ongoing investigations will not only elucidate the precise molecular and cellular mechanisms governing vascular smooth muscle cell reprograming in the pathogenesis of vascular disease and aging; but also provide novel molecular insights facilitating further studies to translate these findings into therapeutic strategies for patient care, so as to improve the veterans’ health, life span and quality of life, and reduce health care costs.

PI_NAMEs: CHEN, YABING  (contact)

PROJECT_TERMS: Aging;Alabama;Animal Model;Atherosclerosis;Award;Blood Vessels;bone;calcification;Cardiovascular Diseases;cardiovascular health;career;Cell Physiology;Cell Reprogramming;Cells;Circadian Dysregulation;circadian pacemaker;Collaborations;Development;Diabetes Mellitus;diabetic;Funding;Gene Expression Regulation;gene function;General Population;Goals;graduate student;Grant;Health;Health Care Costs;Hyperglycemia;improved;innovation;insight;Intervention;Investigation;knockout gene;Knockout Mice;life span;Macrophage;Medical center;Mentors;Military Personnel;Mission;Molecular;Molecular Target;mouse model;new therapeutic target;next generation;novel;osteogenic;Oxidative Stress;Pathogenesis;Patient Care;Phenotype;Physicians;Postdoctoral Fellow;Prevention strategy;programs;Quality of life;Regulation;Research;Research Personnel;Research Project Grants;Role;Scientist;Services;Smooth Muscle Myocytes;stem cells;Therapeutic;Tissues;Training;transcription factor;Translating;United States National Institutes of Health;Universities;Up-Regulation;Vascular calcification;Vascular Diseases;Vascular Smooth Muscle;Veterans

PROJECT_TITLE: BLRD Research Career Scientist Award Renewal


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Schizophrenia is a highly heritable neuropsychiatric disorder for which diagnostic and treatment options are limited. Advances in genetics have started to reveal pathways underlying the disorder, including synaptic biology and enzymes of glycosylation. In this study, I will investigate synaptic alterations caused by the schizophrenia-associated missense variant in SLC39A8, providing mechanistic insights to pathophysiology with clear potential for developing of novel therapeutics.

PI_NAMEs: MEALER, ROBERT G (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TITLE: Synaptic dysglycosylation caused by the schizophrenia-risk variant in SLC39A8


ORG_CITY: SILVER SPRING

ORG_NAME: AUTONOMOUS THERAPEUTICS, INC.

PHR: PROJECT NARRATIVE Persons who inject drugs (PWID) represent a key `superspreader' population for HIV/AIDS that drives the epidemic in the US and other countries and it is exceptionally difficult to identify and reach these high-risk populations with existing intervention strategies (e.g., ART and PrEP). This proposal will develop and test a novel gene-drive concept to target the high-risk superspreaders who most need therapy. Gene drives would be particularly useful for treating PWID and those who engage in injection drug use in resource-limited settings, including the rural US.

PI_NAMEs: WEINBERGER, LEOR S (contact)

PROGRAM_OFFICER_NAME: MANDLER, RAUL N

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Animals;Biological Assay;Brazil;Burkina Faso;Cells;Clinical;Clinical Trials;cohort;Communicable Diseases;Complement;cost;Country;County;Data;Development;Disease;Disease Outbreaks;disorder control;Drug usage;end of life;Engineering;Epidemic;Epidemiologist;Epidemiology;Failure;female sex worker;gene drive system;gene therapy;Genes;genotoxicity;Gifts;high risk;high risk behavior;high risk population;HIV;HIV Infections;HIV therapy;HIV/AIDS;humanized mouse;immunogenicity;In Vitro;Incidence;Indiana;Injecting drug user;injection drug use;Intervention;Intervention Trial;Location;Malaria;Measures;Modeling;Modernization;Nature;nonhuman primate;novel;pathogen;Patients;Phase;Population;pre-exposure prophylaxis;prototype;Reporting;Resistance;Resource-limited setting;Risk Factors;RNA Interference;Rural;Safety;safety testing;synthetic construct;Testing;transmission process;United States National Academy of Sciences;Update;Variant;Viremia

PROJECT_TITLE: A Gene Drive Therapy for HIV: Single-Administration Intervention for High-RiskGroups


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LEWES

ORG_NAME: JOHN SNOW LABS INC

ORG_STATE: DE

PI_NAMEs: UL HAQ, HASHAM  (contact)

PROJECT_TERMS: artificial intelligence model;base;Benchmarking;biomedical ontology;Biomedical Research;Clinical;Code;Data;data management;Data Set;data sharing;Disease;Immune;improved;Information Retrieval;interoperability;knowledge graph;large language model;Mediating;Medical;Metadata;Modeling;Names;Natural Language Processing;novel strategies;Ontology;Phase;Process;Production;Research;Research Personnel;Resolution;Small Business Innovation Research Grant;Standardization;Technology;Text;Time;Training;unstructured data

PROJECT_TITLE: SBIR TOPIC 135:Applying Large Language Models for Automated Entity Recognition, Relation Extraction/Ontology Metadata Enrichment from Free-Text Clinical Notes in Infectious/Immune-Mediated Diseases


NIH_SPENDING_CATS: Data Science

ORG_CITY: MIAMI

ORG_NAME: INFOTECH SOFT, INC.

ORG_STATE: FL

PI_NAMEs: SABATINO, SAMANTHA  (contact)

PROJECT_TERMS: Big Data;biomedical ontology;Biomedical Research;Collection;Communities;Data;Data Aggregation;Data Set;data streams;Disease;Ensure;Generations;Immune;Immunologics;Immunology;Knowledge;knowledge graph;knowledge integration;Mediating;Modeling;multiple data sources;Phase;Productivity;Publishing;Research;Semantics;Small Business Innovation Research Grant;Technology;time use;usability;user centered design

PROJECT_TITLE: SBIR 136 - INFOTECH: Integrated Knowledge Spaces for Infectious and Immune-mediated Disease Research


ORG_CITY: TALLAHASSEE

ORG_NAME: INSILICOM, LLC

PI_NAMEs: ZHANG, JINFENG  (contact)

PROJECT_TERMS: Address;complex data;Coupled;Data;Disease;Evolution;Future;Growth;high throughput technology;Immune;improved;Information Retrieval;Knowledge;Knowledge Discovery;knowledge graph;Literature;Manuals;Mediating;Modeling;National Institute of Allergy and Infectious Disease;Ontology;open source;public database;Publishing;PubMed;Research;Research Personnel;Small Business Innovation Research Grant;Structure;success;Techniques;Text;Training;Update

PROJECT_TITLE: "SBIR TOPIC 136 - INSILICOM: Enhancing a large-scale biomedical knowledge graph for infectious- and immune-mediated disease  research"


NIH_SPENDING_CATS: Bioengineering;Data Science;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CLIFTON PARK

ORG_NAME: KITWARE, INC.

PI_NAMEs: BAUMES, JEFF  (contact)

PROJECT_TERMS: artificial intelligence model;Communicable Diseases;Data;Feedback;graph database;Human;interactive visualization;Intuition;Knowledge;knowledge curation;knowledge graph;large language model;Link;Literature;metabolomics;novel;Ontology;Paper;prompt engineering;prototype;Research;Small Business Innovation Research Grant;structured data;System;Time;tool;Validation;web app

PROJECT_TITLE: SBIR 136 - KITWARE:  Viime Extract: An AI-powered Knowledge Graph Extraction System for Metabolomics


ORG_CITY: CHEVY CHASE

ORG_NAME: MY OWN MED, INC.

PI_NAMEs: SEYFERT-MARGOLIS, VICKI  (contact)

PROJECT_TERMS: Algorithms;Artificial Intelligence;Basic Science;Biomedical Research;Clinical;Clinical Research;Communities;Computer software;Data;Data Reporting;Data Set;design;Development;Disease;Ensure;Immune;Infection;Knowledge;Knowledge Extraction;knowledge graph;large language model;Learning;Literature;Mediating;Medical;Natural Language Processing pipeline;Patients;Phase;Process;programs;prototype;Psychological reinforcement;Publications;Publishing;Research Personnel;Small Business Innovation Research Grant;Students;teacher;web services

PROJECT_TITLE: SBIR 136 - MY OWN MED: Development of automated LLM KG extraction to inform clinical research of infectious & immune mediated diseases


NIH_SPENDING_CATS: Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAN DIEGO

ORG_NAME: OMNISYNC INCORPORATED

PI_NAMEs: HUANG, NORMAN  (contact)

PROJECT_TERMS: Communities;Computer software;Data;Data Compromising;data integrity;Databases;effectiveness evaluation;Generations;Graph;indexing;innovation;insight;Intuition;Journals;Knowledge;knowledge graph;knowledge integration;large language model;machine learning model;Maps;Methodology;Modernization;Nature;Paper;Performance;Publications;Research;Science;Small Business Innovation Research Grant;Source;Standardization;Structure;success;Techniques;Technology;Time;training data;Triplet Multiple Birth;vector;Visual;Work

PROJECT_TITLE: SBIR 136 - OMNISYNC: A Real-Time Comprehensive Knowledge Graph for the Biomedical Science Community


NIH_SPENDING_CATS: Data Science;Infectious Diseases

ORG_CITY: RALEIGH

ORG_NAME: PREDICTIVE, LLC

PI_NAMEs: TROPSHA, ALEX  (contact)

PROJECT_TERMS: Address;Biological;Chemicals;Clinical;Communicable Diseases;Data;diverse data;drug discovery;emerging pathogen;Genomics;Knowledge;knowledge base;knowledge graph;Maps;Mining;Modernization;novel;Pathway interactions;Pharmaceutical Preparations;Pilot Projects;Small Business Innovation Research Grant;Structure;Technology;tool;web portal

PROJECT_TITLE: SBIR 136 - PREDICTIVE: Knowledge Graphs for Infectious Diseases


NIH_SPENDING_CATS: Aging;Congenital Structural Anomalies;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Osteogenesis Imperfecta;Osteoporosis;Pediatric;Prevention;Rare Diseases

ORG_NAME: IQ SOLUTIONS, INC.

PI_NAMEs: ROBINSON, NATE  (contact)

PROJECT_TERMS: Adolescent;Asian;Asian Women;Awareness;Bone Diseases;bone health;Communication;Dedications;Early Diagnosis;Early treatment;Education;General Population;Health Professional;Hispanic Women;Hyperparathyroidism;Individual;Information Dissemination;Knowledge;Language;Link;Low Literacy Population;men;Metabolic Bone Diseases;Osteitis Deformans;Osteogenesis Imperfecta;Osteoporosis;outreach;Pamphlets;Patients;Physicians;Populations at Risk;Prevention;Resources;Spanish;United States Dept. of Health and Human Services;United States National Institutes of Health;Visual impairment

PROJECT_TITLE: PROFESSIONAL COMMUNICATIONS AND OUTREACH SUPPORT


NIH_SPENDING_CATS: Nutrition

PI_NAMEs: MILLER, AMY  (contact)

PROJECT_TITLE: THE CONTRACTOR SHALL PROVIDE SERVICES TO SUPPORT, UPDATE, MAINTAIN, FURTHER DEVELOP AND REFINE THE EXISTING AUTOMATED SELF-ADMINISTERED 24-HOUR DIETARY ASSESSMENT SYSTEM (HENCEFORTH REFERRED TO AS THE


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: MINNEAPOLIS

ORG_NAME: HENNEPIN HEALTHCARE RESEARCH INSTITUTE

ORG_STATE: MN

PI_NAMEs: JOHANSEN, KIRSTEN  (contact)

PROJECT_TERMS: Contracts;Modification

PROJECT_TITLE: MODIFICATION TO THE CONTRACT TO REVISE SECTION J ATTACHMENTS


ORG_NAME: UNIVERSITY OF MINNESOTA

PI_NAMEs: GRZYWACZ, BARTOSZ J (contact)

PROJECT_TERMS: Minnesota;Universities

PROJECT_TITLE: REGENTS OF THE UNIVERSITY OF MINNESOTA:1107499 [24-002026]


ORG_CITY: BETHESDA

ORG_NAME: HILL GROUP THE

PI_NAMEs: SEHHAT, BEVERLY  (contact)

PROJECT_TERMS: National Institute of Diabetes and Digestive and Kidney Diseases;Services

PROJECT_TITLE: NIDDK EPOD ACTIVITIES ADMINISTRATIVE SUPPORT SERVICES TASK ORDER


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: EAGLE BUTTE

ORG_NAME: MISSOURI BREAKS RESEARCH, INC.

ORG_STATE: SD

PROJECT_TITLE: STRONG HEART STUDY (SHS)-MISSOURI BREAKS INDUSTRIES RESEARCH, INC.- FIELD CENTER (FC), TASK AREA B.3, YEAR 3


NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PI_NAMEs: ALI, TAUQEER  (contact)

PROJECT_TERMS: American Indians;Area;Collaborations;Communities;Contractor;Data;Disabled Persons;disadvantaged background;Disparity population;Ethnic Population;experience;follow-up;Funding;Funding Opportunities;Health;Heart;Investigation;Investigator-Initiated Research;member;Mentors;Mission;National Heart, Lung, and Blood Institute;Oklahoma;Pilot Projects;Postdoctoral Fellow;programs;racial population;Research;Research Personnel;Research Project Grants;tribal college;tribal community;Tribes;Universities;university student

PROJECT_TITLE: STRONG HEART STUDY (SHS)- UNIVERSITY OF OKLAHOMA-FIELD CENTER (FC), TASK AREA B.3, YEAR 3


NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

PI_NAMEs: ZHANG, YING  (contact)

PROJECT_TERMS: American Indians;Area;Collaborations;Communities;Contractor;Data;Disabled Persons;disadvantaged background;Disparity population;Ethnic Population;experience;follow-up;Funding;Funding Opportunities;Health;Heart;Investigation;Investigator-Initiated Research;member;Mentors;Mission;National Heart, Lung, and Blood Institute;Pilot Projects;Postdoctoral Fellow;programs;racial population;Research;Research Personnel;Research Project Grants;tribal college;tribal community;Tribes;university student

PROJECT_TITLE: STRONG HEART STUDY (SHS)- COORDINATING CENTER (CC)- TASK AREA B.3, YEAR 3


ORG_CITY: HYATTSVILLE

ORG_NAME: MEDSTAR HEALTH RESEARCH INSTITUTE

PROJECT_TITLE: STRONG HEART STUDY (SHS)-MEDSTAR HEALTH RESEARCH INSTITUTE- FIELD CENTER (FC), TASK AREA B.3, YEAR 3


ORG_CITY: WINSTON-SALEM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative – Public Health Relevance Peripheral arterial disease (PAD) is caused by atherosclerosis in the legs where blood flow is restricted. The central focus of PAD research for decades has been to understand and alter endothelial cell biology, yet no progress has been made towards effective therapeutic design. We will combine our use of innovative mouse genetic models, established PAD relevant laboratory models, innovative tools (gene therapy designed expression viruses), and a heterogeneous PAD patient population to fully interrogate the role of BAG3 as both a potential cause of pathology (in the case of the variants pre-disposing African Americans to severe disease outcomes) and as a potential target for therapeutic development.

PI_NAMEs: MCCLUNG, JOSEPH MATTHEW (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Adenoviruses;Affect;African American;African American population;African ancestry;Amino Acids;Amputation;angiogenesis;Apoptosis;Arteries;Atherosclerosis;Automobile Driving;BCL2 gene;biobank;Bioenergetics;Biological;Blood flow;Blood Vessels;Cardiac;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;Cell Separation;cell type;Cells;Cellular biology;Cessation of life;Clinical;Code;cohort;Communication;complex IV;critical limb Ischemia;cytochrome c oxidase;Data;demographics;density;design;Dilated Cardiomyopathy;Disease;Disease Outcome;Disparity;Endothelial Cells;Environment;Exertion;Gangrene;gene therapy;Genes;Genetic;Genetic Models;genetic variant;Glycolysis;Hindlimb;Histologic;Human;improved;In Vitro;in vivo;Inbred BALB C Mice;Incidence;Individual;Injury;innovation;Intermittent Claudication;Ischemia;Laboratories;Leg;limb ischemia;Limb structure;Link;Lower Extremity;Mediating;Medical;Metabolic;Mitochondria;mitochondrial dysfunction;Modeling;Molecular Chaperones;Morbidity - disease rate;mortality;mouse genetics;Mus;Muscle;Muscle Cells;Muscle Fibers;Muscle Mitochondria;muscle regeneration;Mutation;Myocardium;myogenesis;Myopathy;Natural regeneration;necrotic tissue;neovascularization;novel;Outcome;Outcome Measure;overexpression;Pain;paracrine;Pathology;patient population;Patient-Focused Outcomes;Patients;Perfusion;Peripheral;Peripheral arterial disease;Pharmaceutical Preparations;Phenotype;Physiological;pleiotropism;Pre-Clinical Model;preclinical study;Preclinical Testing;Prevention;Procedures;Process;Proliferating;Proteins;public health relevance;Quantitative Trait Loci;Race;racial disparity;Recovery;Research;Research Personnel;Rest;restoration;revascularization;Risk;Role;Scaffolding Protein;screening;skeletal;Skeletal Muscle;Striated Muscles;Surgeon;targeted treatment;Testing;Therapeutic;therapeutic candidate;therapeutic development;Therapeutic Effect;therapeutically effective;therapy design;Tissues;tool;Transgenic Organisms;translational scientist;Variant;Virus;Work

PROJECT_TITLE: Variant Determinants of African American Limb Pathology in Peripheral Arterial Disease

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer;Tobacco;Tobacco Smoke and Health

ORG_NAME: NATIONAL CANCER INSTITUTE

PROJECT_TERMS: American;Censuses;Cessation of life;Data;data access;data registry;Data Set;Databases;Development;Evaluation;Funding;indexing;Link;Malignant Neoplasms;Morbidity - disease rate;mortality;National Cancer Institute;National Heart, Lung, and Blood Institute;neoplasm registry;Policies;population survey;Process;Research;Research Personnel;Tobacco;Tobacco use;United States National Center for Health Statistics;United States National Institutes of Health

PROJECT_TITLE: Tobacco Longitudinal Mortality Study (TLMS)


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Dissemination and Implementation Research;Genetics;Health Services;Human Genome;Precision Medicine;Prevention

PROJECT_TERMS: Agreement;Applied Research;Awareness;Benchmarking;Cancer Burden;Cancer Control;cancer genomics;cancer prevention;career;Clinical;Collaborations;Communication;Community Practice;Consultations;Data Set;Division of Cancer Control and Population Sciences;Division of Cancer Prevention;Evaluation;evidence base;Fellowship;Foundations;General Population;Genome;Genomics;Health;health application;Health Personnel;Healthcare;Hereditary Malignant Neoplasm;implementation science;implementation strategy;Knowledge;knowledge base;Malignant Neoplasms;online course;Pilot Projects;population health;Population Surveillance;Precision Health;programs;Provider;Public Health;public health research;Publishing;Research;Research Personnel;Research Training;Resources;Scanning;social media;symposium;Testing;tool;Training;Translating;Translations;United States;Update;web page;webinar

PROJECT_TITLE: A Public Health Foundation for Translating Genomics and Precision Health Applications into Cancer Control and Prevention - 2024 TIDIRC Genomics


NIH_SPENDING_CATS: Bioengineering;Lung

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PI_NAMEs: SEVERYNSE-STEVENS, DIANA M (contact)

PROJECT_TERMS: Agreement;Airway Disease;Analytical Chemistry;Animals;Blood;Canis familiaris;Cardiac;Catheters;Certification;clinical candidate;Contractor;Cyclic GMP;Cystic Fibrosis Transmembrane Conductance Regulator;Development;Devices;Documentation;Dose;drug candidate;Ensure;Formulation;Goals;hemoglobin polymer;Human;inhibitor;Integrins;Liver Microsomes;Lung;manufacture;manufacturing scale-up;Mediation;metabolic abnormality assessment;method development;Methods;Monkeys;National Heart, Lung, and Blood Institute;next generation;novel;Pharmaceutical Preparations;Phase;Plasma;Polychlorinated Biphenyls;Polymers;pre-clinical;Process;programs;prototype;Public Health;Rattus;Recovery;Regenerative Medicine;respiratory;Respiratory Mucosa;Robotics;Safety;safety study;Services;Sickle Cell Anemia;Site;Site Visit;small molecule;Source;Technology Transfer;Testing;Toxicology;Umbilical Cord Blood Transplantation;Update;Validation;Work

PROJECT_TITLE: NHLBI CATALYZE PROGRAM - PRECLINICAL SERVICES COMPONENT - PROJECTS YEAR 3


PROJECT_TERMS: Award;collaborative environment;commercialization;Contracts;Development;Development Plans;Future;Goals;National Heart, Lung, and Blood Institute;Play;preclinical development;product development;programs;Regulatory Affairs;Research;Research Personnel;Role;Services;Source

PROJECT_TITLE: NHLBI CATALYZE COORDINATING CENTER - PRODUCT DEVELOPMENT SUPPORT SERVICES YEAR 2


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Age Years;Area;base;Behavior;Behavioral Risk Factor Surveillance System;cancer risk;Censuses;County;Hispanic;Population;Race;Risk Factors;screening;sex;Sum

PROJECT_TITLE: Estimates of Resident Population for Counties - Small Area Estimation for Cancer Risk Factors and Screening Behaviors by Combining NHIS and BRFSS for 2021 to 2022


ORG_CITY: FAIRFAX

ORG_STATE: VA

PI_NAMEs: ROBINSON, MINDY  (contact)

PROJECT_TERMS: Link;National Institute of Diabetes and Digestive and Kidney Diseases

PROJECT_TITLE: NIDDK / HALO LINK 1-YEAR SMS  POP: 9/1/2024 THRU 8/31/2025


ORG_CITY: GAITHERSBURG

ORG_NAME: SCIENTIFIC CONSULTING GRO

PI_NAMEs: NA, NA  (contact)

PROJECT_TERMS: Logistics;National Institute of Diabetes and Digestive and Kidney Diseases;symposium

PROJECT_TITLE: NIDDK - ACQUISITION OF SCIENTIFIC CONFERENCE AND LOGISTICS SUPPORT FOR THE NIDDK


PROJECT_TERMS: Agreement;cancer care;care delivery;care outcomes;care systems;Data;data exchange;Data Linkages;Data Protection;data registry;Data Set;Data Storage and Retrieval;Documentation;end of life;Enrollment;Health;health assessment;health care delivery;Health Personnel;Healthcare;Individual;insight;Institutional Review Boards;Link;Malignant Neoplasms;Medicaid;Medicare;Medicare/Medicaid;National Cancer Institute;neoplasm registry;Outcome;Persons;Policies;Population;Population Research;Process;Recording of previous events;Research;Role;screening;Screening for cancer;service programs;surveillance data;Surveys;System;trend;United States;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health

PROJECT_TITLE: Centers for Medicare & Medicaid Services (CMS) Data Linkages


NIH_SPENDING_CATS: Urologic Diseases

ORG_CITY: BURLINGAME

ORG_NAME: ACUMEN, LLC

PI_NAMEs: YE, LEI SANDY  (contact)

PROJECT_TERMS: National Institute of Diabetes and Digestive and Kidney Diseases;Services;Urologic Diseases

PROJECT_TITLE: NIDDK: SERVICES: UROLOGICAL DISEASES IN AMERICA (UDA) COMPENDIUM.


NIH_SPENDING_CATS: Clinical Research;Health Services;Patient Safety;Social Determinants of Health

ORG_CITY: LINCOLN

ORG_NAME: QUALITYMETRIC, INC.

ORG_STATE: RI

PI_NAMEs: GREENING, TANYA  (contact)

PROJECT_TERMS: Data;Disease;Electronic Health Record;health care availability;Research Support;trend

PROJECT_TITLE: THE PURPOSE OF THIS REQUIREMENT IS TO PROVIDE ACCESS TO HEALTHCARE CLAIMS DATA AND ELECTRONIC HEALTH RECORDS (EHR) TO SUPPORT THE RESEARCH AND ANALYSIS OF NATIONAL DISEASE AND CONDITION TRENDS THAT RE


NIH_SPENDING_CATS: Cancer;Cannabinoid Research;Natural Products;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

PROJECT_TERMS: Acetaldehyde;Adult;aged;Agreement;Aromatic Polycyclic Hydrocarbons;behavioral study;Cancer Etiology;Cannabinoids;Cannabis;Carbon Monoxide;Carcinogen exposure;carcinogenicity;Carcinogens;Characteristics;Cigar;Cigarette;Data;Data Collection;Disease Outbreaks;District of Columbia;Dryness;epidemiology study;Etiology;experimental study;Filler;Flowers;Formaldehyde;Funding;Future;Health;Hemp;Individual;Investments;Journals;Laboratories;Legal;Length;Licensure;Long-Term Effects;Malignant Neoplasms;Manuscripts;marijuana smoke;Marijuana Smoking;marijuana use;Marketing;Medical Marijuana;Mercury;Metals;Methodology;Molecular;Nicotine;Peer Review;Pharmaceutical Preparations;Plants;Play;Publications;Publishing;Recording of previous events;Recreation;Reporting;Research;Role;Science;Smoke;Source;symposium;Tars;Testing;Tetrahydrocannabinol;Tobacco;tobacco products;Tobacco smoke;toxicant;United States;United States Substance Abuse and Mental Health Services Administration;volatile organic compound;Volatilization;Weight;Writing

PROJECT_TITLE: CDC Examination of Cannabis Smoke for Carcinogens


NIH_SPENDING_CATS: Cancer;Prevention

PROJECT_TERMS: Agreement;authority;Cancer Control;Censuses;Chronic Disease;Collaborations;Computer Security;Consultations;cost;Data;data centers;Data Collection;data exchange;Data Files;data integrity;data quality;Data Security;data sharing;design;disorder prevention;Ensure;Funding;Grant;Health Promotion;Institutional Review Boards;instrument;Interviewer;Maintenance;Malignant Neoplasms;National Health Interview Survey;operation;Preparation;Publications;quality assurance;Questionnaire Designs;Research;Sampling;Security;Surveys;Testing;Training;Travel;United States National Center for Health Statistics;web site

PROJECT_TITLE: Cancer Questions on the 2025 National Health Interview Survey


NIH_SPENDING_CATS: Mental Health

ORG_CITY: HORSHAM

ORG_NAME: NATIONAL MEDICAL SERVICES, INC.

ORG_STATE: PA

PI_NAMEs: BLUM, LEE  (contact)

PROJECT_TERMS: Autopsy;Blood;Brain;Databases;drug of abuse;Human;Pharmaceutical Preparations;Sampling;screening;Secure;Test Result;Testing;testing services;Therapeutic;Tissues;Toxic Environmental Substances;Toxicology;United States National Institutes of Health

PROJECT_TITLE: UNSPECIFIED [24-000022]


ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE. Alzheimer's disease (AD) is the sixth leading cause of death in the United States, affecting almost 6 million people which is expected to more than double by mid-century. The neuropathologic hallmarks of AD including β-amyloid (Aβ) plaques and tau neurofibrillary tangles accumulate in the brain decades before symptom onset, and drive downstream neurodegeneration, cognitive impairment, and death. Identifying genetic drivers of early neuropathologic changes like conversion to Aβ positivity (Aβ+) may lead to novel therapeutic targets useful earlier in the disease cascade when treatment is most effective.

PI_NAMEs: KORAN, MARY ELLEN IRENE (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TITLE: Genetic architecture of age of onset of amyloid positivity: Integrating imaging and genetic tools to identify novel drivers of disease


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Osteoporosis

ORG_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

PROJECT_TERMS: Dual-Energy X-Ray Absorptiometry;Hip region structure;National Health and Nutrition Examination Survey;Osteoporosis;United States National Center for Health Statistics;Vertebral column

PROJECT_TITLE: FY2024 NHANES DXA Osteoporosis  Assessment Component/Study


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: GRADIENT HEALTH INC

PI_NAMEs: HUANG, OUWEN  (contact)

PROJECT_TERMS: Algorithms;artificial intelligence algorithm;Breast Cancer Detection;breast density;Characteristics;Cone;Data;Data Set;Databases;demographics;diversity and equity;Ethnic Origin;Ethnic Population;Exhibits;Genotype;Goals;Health system;Impairment;indexing;Ingestion;Mammary Neoplasms;Mammography;Manufacturer;Medical Device;Medical Imaging;Metadata;Modeling;Multimodal Imaging;Pathology;Performance;Physiological;Race;racial population;Reporting;screening;software as a medical device;systems research;tool development;Training;training data;Tumor Markers;Variant;vector

PROJECT_TITLE: ADVANCING EQUITY AND DIVERSITY IN BREAST CANCER SCREENING: CREATING A FOUNDATIONAL DATASET AND TOOLSET.


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Congenital Structural Anomalies;Gene Therapy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: BATTELLE CENTERS/PUB HLTH RES & EVALUATN

PHR: VIRAL GENE THERAPY FOR MENKES DISEASE

PI_NAMEs: BURNAUGH, AMANDA  (contact)

PROJECT_TERMS: animal safety;Disease;Funding;gene therapy;Menkes Kinky Hair Syndrome;National Institute of Neurological Disorders and Stroke;pre-clinical;Toxicology;U-Series Cooperative Agreements;Viral Genes

PROJECT_TITLE: VIRAL GENE THERAPY FOR MENKES DISEASE


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHICAGO

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Pannexin (PANX1-3) are important ATP-release channels playing critically physiological roles ranging from blood pressure regulation, glucose uptake, apoptotic cell clearance, tumor metastasis, ischemia-reperfusion, human oocyte development to skin/skeleton development. The proposed study focuses on untangling the oligomeric state, channel assembly, molecular structure, gating mechanism, and pharmacology of the PANX1-3, taking advantage of single-particle cryo-EM, electrophysiology, and other functional approaches. The proposed research is relevant to public health and NIH’s mission because this work will provide a deep understanding and broaden our knowledge of the relationships between atomic structures and the complex biological and pathological functions of PANXs, paving the way for the development of therapeutics to treat pannexin-related diseases.

PI_NAMEs: LU, WEI  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TITLE: Elucidating structures and molecular mechanisms of Pannexin channels

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: MENANDS

ORG_NAME: NYSDOH/HEALTH RESEARCH, INC.

ORG_STATE: NY

PI_NAMEs: MANTIS, NICHOLAS  (contact)

PROJECT_TERMS: Advanced Development;Antigens;B-Lymphocyte Epitopes;Borrelia burgdorferi;decorin binding protein B;Diagnostic;Epitope Mapping;Epitopes;Goals;Human;human monoclonal antibodies;Immunity;In Vitro;in vivo;Infection;innovation;Lipoproteins;Lyme Disease;Lyme Disease Vaccines;Modeling;novel;OspC protein;Patients;Resolution;Sampling;Serum;Surface;Surface Antigens;Techniques;Testing;Therapeutic;transmission process;United States;vector-borne infection

PROJECT_TITLE: Innovations in Functional B Cell Epitope Discovery for Lyme Disease


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_NAME: DUKE UNIVERSITY

PI_NAMEs: KELSOE, GARNETT  (contact)

PROJECT_TERMS: Animals;Antibodies;B-Lymphocyte Epitopes;Binding;Clone Cells;Crystallography;Epidemic;Epitopes;Goals;Hemagglutinin;Human;Immunologic Memory;In Vitro;Influenza;Influenza A virus;Influenza B Virus;influenza infection;influenza virus strain;influenzavirus;innovation;Location;Memory B-Lymphocyte;Monoclonal Antibodies;Mus;Neuraminidase;novel;pandemic influenza;protective efficacy;Recombinant Antibody;Site;Structure;transmission process;Virus

PROJECT_TITLE: Innovations in Functional B Cell Epitope Discovery for Influenza


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Endocrine Disruptors

ORG_NAME: BATTELLE MEMORIAL INSTITU

PI_NAMEs: FALLACARA, DAWN  (contact)

PROJECT_TERMS: Address;Adverse effects;Alkanesulfonates;animal data;carboxylate;carcinogenicity;Chemicals;Complex Mixtures;Data;Dose;Environment;epidemiologic data;exposed human population;Exposure to;Female;Foundations;Future;in vivo;Individual;Joints;Liver;male;Modeling;Poly-fluoroalkyl substances;Rattus;Risk;Risk Assessment;System;Testing;Thyroid Gland;Thyroxine;Toxic effect;Toxicokinetics;Weight

PROJECT_TITLE: In Vivo Assessment of an Equimolar or Environmentally Relevant Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) Mixture


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Endocrine Disruptors;Genetics;Human Genome;Prevention;Rare Diseases

PROJECT_TERMS: Address;Benchmarking;Biological;Biological Assay;Chemicals;Collaborations;Communities;Data;Data Collection;Decision Making;Deodorants;developmental toxicity;Dose;Evaluation;genomic data;Genomics;hazard;high dimensionality;in vivo;Inhalation;Inhalation Exposure;Link;malignant mouth neoplasm;member;Methodology;Moths;Mus;National Toxicology Program;Oral;Property;Rattus;reproductive toxicity;Research;response;Risk;Risk Assessment;Testing;Toxic effect;Toxicology;transcriptomics;United States Environmental Protection Agency

PROJECT_TITLE: Short-term Transcriptomic Studies of 1,2-Dichlorobenzene and 1,4-Dichlorobenzene following Whole-body Inhalation Exposure in Rats and Mice


NIH_SPENDING_CATS: Data Science;Genetics;Human Genome

ORG_CITY: MIDDLETON

ORG_NAME: BIOTEAM, INC.

PI_NAMEs: JESSEL, CINDY  (contact)

PROJECT_TERMS: Address;Assessment tool;Characteristics;Collaborations;Communities;Computer software;Data;data ecosystem;data repository;Ecosystem;Educational workshop;Evaluation;Evaluation Reports;Extramural Activities;FAIR principles;Funding;genome resource;genomic data;Institution;Interview;National Human Genome Research Institute;Phase;public health relevance;Recommendation;Research;Research Personnel;Resources;Self Assessment;United States National Institutes of Health

PROJECT_TITLE: DATA AND SOFTWARE RESOURCES ECOSYSTEM


ORG_CITY: MINNEAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE Acute lung injury as a result of the systemic inflammatory response (SIRS) is a common cause of complications in patients following severe injury. Unfortunately, therapeutics that limit SIRS after injury are lacking, with poor translation of therapeutics from animal models into patients in the clinical setting. Here, we will identify the function and mechanism of action of uniquely human genes that are highly expressed in monocytes/macrophages, define their contribution to human SIRS, and understand how these genes effect therapeutics that target anti-inflammatory signaling pathways.

PI_NAMEs: COSTANTINI, TODD W (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TITLE: Mechanism of action of uniquely human genes in the injury response


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Cardiovascular;HIV/AIDS;Heart Disease;Infectious Diseases

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adult;Affect;Animal Model;antiretroviral therapy;Biochemical;cardiometabolism;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;Chronic;Data;Diagnosis;Disease;Dose;Echocardiography;embryo/fetus;Exposure to;Fetus;Functional disorder;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;Immunocompromised Host;Individual;Infection;Inflammation;Lactation;Lamivudine;Modeling;Mothers;Myocarditis;Oral;Persons;Pharmaceutical Preparations;Phenotype;Population;Pregnancy;Rattus;Risk;Therapeutic;Toxic effect;Virus;Virus Diseases

PROJECT_TITLE: STUDIES TO EVALUATE THE CARDIOVASCULAR TOXICITY OF AN HIV TRICOMBO THERAPY (ABC/DTG/3TC) IN SPRAGUE DAWLEY (HSD: SPRAGUE DAWLEY® SD®) RATS (F0 DOSED BY ORAL GAVAGE


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PI_NAMEs: DOHENY, KIM  (contact)

PROJECT_TERMS: Adult Children;Age;Benchmarking;biobank;Bioinformatics;bioinformatics tool;Biology;Blood;Blood specimen;Blood Tests;Cell Line;Child;Clinic;Communities;Consent;Data;database of Genotypes and Phenotypes;de novo mutation;Development;Disease;DNA;DNA Insertion Elements;DNA sequencing;empowerment;Enrollment;Event;Family;Family member;Generations;Genes;Genetic;Genetic Recombination;Genetic study;Genetic Variation;Genome;genome sequencing;Genomic DNA;genomic variation;Genomics;Genotype;Germ Lines;Germ-Line Mutation;grandparent;Health;Hereditary Disease;Human;Human Genome;Human Resources;Individual;Joints;kindred;Longevity;Lymphocyte Activation;Maps;Measurement;Medical Research;member;Menopause;method development;Methods;Morphologic artifacts;Mutation;National Human Genome Research Institute;neuronal cell body;Nucleotides;offspring;Parents;Participant;Personality Tests;Phenotype;phenotypic data;Platinum;Publications;Questionnaires;Research;Resources;Saliva;Sampling;segregation;Sensory;Short Tandem Repeat;Software Tools;Technology;Testing;tool;trait;transmission process;Universities;Utah;Variant;whole genome

PROJECT_TITLE: HIGH THROUGHPUT GENOTYPING AND DNA SEQUENCING FOR STUDYING THE GENETIC CONTRIBUTIONS TO HUMAN HEALTH AND DISEASE -WHOLE GENOME SEQUENCING (30X) FOR NHGRI (QUINLAN)


NIH_SPENDING_CATS: Prevention

PROJECT_TERMS: Adverse effects;Benzene;carcinogenicity;Chemicals;Data;design;Development;disorder prevention;Environmental Exposure;ethylbenzene;exposure route;Exposure to;Goals;Hazard Identification;Hazardous Chemicals;Health;Histopathology;Human;Inhalation;Laboratory Animals;Lung;Mission;Mus;public health research;Rattus;Reporting;Risk;Risk Assessment;sound;Toluene;Toxic effect;Toxicity Tests;Toxicology;Xylene

PROJECT_TITLE: Conduct of studies to evaluate the toxic potential of mixed xylenes in laboratory animals


NIH_SPENDING_CATS: Cancer;Lung;Prevention

PROJECT_TERMS: Adverse effects;Amphiboles;Asbestos;carcinogenicity;Chemicals;Chronic;Data;design;Development;disorder prevention;Environmental Exposure;Exposure to;Fiber;Goals;Hazard Identification;Hazardous Chemicals;Health;Histopathology;Human;Inhalation;Inhalation Exposure;Laboratory Animals;Lung;lung development;method development;Methods;Mineral Fibers;Mission;Nose;Phase;Preparation;public health research;Rattus;Reporting;Risk Assessment;Risk Factors;sound;Source;Tissues;Toxic effect;Toxicity Tests;Toxicology;Work

PROJECT_TITLE: Conduct of studies to evaluate the toxic and carcinogenic potential of naturally occurring asbestos and related mineral fibers in laboratory animals


NIH_SPENDING_CATS: Endocrine Disruptors;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

PROJECT_TERMS: Adverse effects;Chemicals;consumer product;Data;design;Development;developmental neurotoxicity;developmental toxicity;disorder prevention;Dose;Environment;Environmental Exposure;Evaluation;Exposure to;Flame Retardants;General Population;Goals;Hazard Identification;Hazardous Chemicals;Health;Human;inorganic phosphate;Lactation;Mission;Perinatal Exposure;Phenols;Pregnancy;public health research;Rattus;Risk Assessment;sound;Toxic effect;Toxicity Tests;Toxicology;Weaning

PROJECT_TITLE: Conduct of studies to evaluate the subchronic and developmental neurotoxicity of isopropylated phenol phosphate (IPP) and triphenyl phosphate (TPHP)in rats (after perinatal exposure)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_NAME: FAST TRACK DRUGS AND BIOL

PI_NAMEs: RIGGS, KATRINA  (contact)

PROJECT_TERMS: alcohol abuse therapy;alcohol use disorder;Contractor;drug testing;Preparation;Protocols documentation

PROJECT_TITLE: CONTRACTOR WILL ASSIST WITH PREPARATION OF FDA INFORMATION PACKAGE AND DISCUSSION OF THE PROTOCOL SYNOPSIS FOR DRUG TESTING FOR THE TREATMENT OF ALCOHOL USE DISORDER.


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Aerosols;Air;Air Pollutants;Animals;Cells;Complex Mixtures;Data;Data Correlations;design;Dryness;Evaluation;exposure route;Fiber;Goals;Government;Health Hazards;Human;In Vitro;in vitro testing;in vivo;Industrialization;Inhalation;Inhalation Exposure;Liquid substance;Lung;pilot test;Population;Powder dose form;programs;Rattus;System;Testing;Tissues;toxicant;Toxicity Tests;Toxicology;vapor

PROJECT_TITLE: Establish and Characterize an Air Liquid Interface In Vitro Exposure System


PROJECT_TERMS: Animals;Apical;Blood Pressure;Case Study;Chemicals;design;Early Intervention;Euthanasia;Evaluation;Exposure to;Health;Heart Rate;heart rate variability;Histopathology;Human;Implant;Inhalation;Laboratory Animal Medicine;Outcome;Physiologic Monitoring;Telemetry;Testing;Toxic effect;Toxicology

PROJECT_TITLE: Evaluation of Physiological Monitoring in Toxicology using 2-Ethyltoluene as a case study


NIH_SPENDING_CATS: Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Rare Diseases

ORG_CITY: COLUMBIA

PI_NAMEs: MILSTEAD, KERRY  (contact)

PROJECT_TERMS: Advocacy;Clinical Research;Communities;Disease;experience;Family;genetic counselor;Genetic Diseases;Hand;Health Professional;Information Centers;Information Specialists;member;National Center for Advancing Translational Sciences;National Human Genome Research Institute;Nurses;Occupational Therapist;Patients;Persons;physical therapist;Physicians;programs;Rare Diseases;Research;Research Support;Resources;Scientist;Social Workers;Spanish/English;teacher;United States National Institutes of Health;virtual;Work;Writing

PROJECT_TITLE: MANAGEMENT AND RESEARCH SUPPORT FOR THE GENETIC AND RARE DISEASES (GARD) INFORMATION CENTER AND RELATED PROGRAMS


ORG_CITY: NORTH BETHESDA

ORG_NAME: AXLE INFORMATICS, LLC

PI_NAMEs: MAYS, GARY  (contact)

PROJECT_TERMS: National Institute on Alcohol Abuse and Alcoholism;System

PROJECT_TITLE: NIAAA PAY PLAN SOLUTION SYSTEM AND MICROSOFT AZURE CLOUD SUPPORT


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Social Determinants of Health;Substance Misuse

ORG_CITY: SILVER SPRING

ORG_NAME: SYNERGY ENTERPRISES, INC.

PI_NAMEs: SPARKS, ALICIA  (contact)

PROJECT_TERMS: alcohol policy information system;National Institute on Alcohol Abuse and Alcoholism

PROJECT_TITLE: NIAAA ALCOHOL POLICY INFORMATION SYSTEM APIS


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

PI_NAMEs: OLIVO, VANESSA  (contact)

PROJECT_TERMS: Clinical Research;Contractor;Contracts;Epidemiology;Equipment;Future;Government;Government Agencies;Human Resources;Immunologic Epidemiology;Infection;Performance;Progress Reports;Qualifying;Reporting;Services;study population;tumor;Work

PROJECT_TITLE: INFECTIONS AND IMMUNOEPIDEMIOLOGY BRANCH (IIB) & INTEGRATIVE TUMOR EPIDEMIOLOGY BRANCH (ITEB) SUPPORT SERVICES


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections

ORG_CITY: BETHESDA

ORG_NAME: TECHNICAL RESOURCES INTERNATIONAL, INC.

PI_NAMEs: KESSLAR, TIMOTHY  (contact)

PROJECT_TERMS: Archives;Caribbean region;Clinic;Clinical Trials;Clinical Trials Network;Collection;Data;Division of Cancer Prevention;HIV;Human Papillomavirus;improved;Information Technology;Language;Latin American;Maintenance;Persons;Portuguese;prevention clinical trial;programs;Reporting;Site;Spanish

PROJECT_TITLE: CLINICAL TRIALS ACCRUAL QUALITY IMPROVEMENT PROGRAM (AQUIP) DATA AND INFORMATION TECHNOLOGY SUPPORT FOR THE US-LATIN AMERICAN-CARIBBEAN HIV/HPV PREVENTION CLINICAL TRIALS NETWORK (ULACNET)


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Eye Disease and Disorders of Vision;Neurosciences;Substance Misuse

ORG_CITY: WASHINGTON

ORG_NAME: NATIONAL ACADEMY OF SCIENCES

ORG_STATE: DC

PI_NAMEs: DAY, ROBERT  (contact)

PROJECT_TERMS: Neurosciences

PROJECT_TITLE: FY24 IC SUPPORT FOR THE NEUROSCIENCE FORUM


ORG_NAME: IQ SOLUTIONS, INC.

PI_NAMEs: STEARMAN, KATHLEEN  (contact)

PROJECT_TERMS: alcohol research;Publications

PROJECT_TITLE: MANAGING, EDITING, AND PUBLICATION OF ALCOHOL RESEARCH: CURRENT REVIEWS


PI_NAMEs: BRACKETT, THOMAS  (contact)

PROJECT_TERMS: improved;web site

PROJECT_TITLE: TO SUPPORT AND IMPROVE THE INSTITUTE'S ABILITY TO PROVIDE ACCURATE, RELEVANT, AND UP-TO-DATE INFORMATION ON ITS PUBLIC WEBSITES.


ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PI_NAMEs: TISCHFIELD, JAY  (contact)

PROJECT_TERMS: DNA

PROJECT_TITLE: NESARC-III DNA STORAGE


ORG_STATE: MD

PI_NAMEs: STRAIN, ERIC  (contact)

PROJECT_TITLE: CORE FUNCTION ACTIVITIES TASK ORDER FOR ADVISORY SERVICES AND ADMINISTRATIVE REPORTING


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PI_NAMEs: HUTCHISON, KENT  (contact)

PROJECT_TITLE: CORE FUNCTION ACTIVITIES TASK ORDER FOR ADVISORY SERVICES AND ADMINISTRATIVE REPORTING.  TASK ORDER NUMBER 75N94021D00016 75N94021F00001 ADMINISTRATIVELY REPLACES TASK ORDER NUMBER 75N94021D00009 75N9


NIH_SPENDING_CATS: Aging;Neurosciences

PROJECT_TERMS: Aging;Neurosciences

PROJECT_TITLE: FY24 IC SUPPORT FOR THE NEUROSCIENCE FORUM - Aging


NIH_SPENDING_CATS: Aging;Regenerative Medicine

PROJECT_TERMS: Aging;Regenerative Medicine

PROJECT_TITLE: FORUM ON REGENERATIVE MEDICINE - Aging


NIH_SPENDING_CATS: Aging;Disability Research

PROJECT_TERMS: Aging;disability

PROJECT_TITLE: IFG::OT::IFG: FORUM ON AGING, DISABILITY, AND INDEPENDENCE - Aging


NIH_SPENDING_CATS: Aging;Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PROJECT_TERMS: Aging;Traumatic Brain Injury

PROJECT_TITLE: FORUM ON TRAUMATIC BRAIN INJURY - Aging


NIH_SPENDING_CATS: Aging

PI_NAMEs: ROBINSON, NATE  (contact)

PROJECT_TERMS: Aging;Communication;outreach

PROJECT_TITLE: PROFESSIONAL COMMUNICATIONS AND OUTREACH SUPPORT - Aging


ORG_CITY: WILMINGTON

ORG_NAME: CHARLES RIVER LABORATORIES INTNTL, INC.

ORG_STATE: MA

PI_NAMEs: URIAS, SERGIO  (contact)

PROJECT_TERMS: Aging;Development;Maintenance;old mice

PROJECT_TITLE: DEVELOPMENT AND MAINTENANCE OF A MULTIGENOTYPIC AGED MOUSE COLONY - Aging


PROJECT_TITLE: DEVELOPMENT AND MAINTENANCE OF A MULTIGENOTYPIC AGED RAT COLONY


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Regulation of residue-specific protein ADP-ribosylations by ADP-ribosyl-acceptor hydrolases (ARHs) is important for cellular responses to DNA damage and the uncontrolled accumulation of ADP-ribosylations causes genomic instability, often leading to diseases. We aim to develop new quantitative tools that selectively monitor the reversal of different residue-specific ADP-ribosylations by ARHs and to elucidate the mechanisms of substrate selectivity and cleavage of ARHs. Our studies will overcome the existing technical hurdles in selective and quantitative measurement of site-specific ADP-ribosylations and will provide in-depth understanding of the roles of each enzymatic activity of ARHs in maintaining genomic integrity.

PI_NAMEs: KIM, IN-KWON  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TITLE: Reversal of residue-specicific ADP-ribosylations by ADP-ribosyl-acceptor hydrolases

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Regenerative Medicine

PI_NAMEs: BEACHY, SARAH H (contact)

PROJECT_TERMS: Development;Educational workshop;effective therapy;ethical, legal, and social implication;Fostering;information gathering;interest;Marketing;meetings;Patients;Policies;Regenerative Medicine;Science;Therapeutic;Translations;Work

PROJECT_TITLE: FORUM ON REGENERATIVE MEDICINE


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PROJECT_TITLE: GINV: 75090421: CENTERS FOR DI


ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PI_NAMEs: DMITROVSKY, ETHAN  (contact)

PROJECT_TITLE: NCI FY25 OPERATIONAL TASK ORDER


ORG_CITY: FAIRFAX

PI_NAMEs: KHOSLA, MRINAL  (contact)

PROJECT_TERMS: Logistics;National Institute of Child Health and Human Development;Services

PROJECT_TITLE: NICHD SERVICES: FIC LOGISTICS SUPPORT


ORG_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


NIH_SPENDING_CATS: Diabetes

PROJECT_TERMS: Diabetes Mellitus;National Health and Nutrition Examination Survey

PROJECT_TITLE: National Health and Nutrition Examination Survey 2019-2020 Diabetes Component


ORG_CITY: Rockville

ORG_NAME: DIGITAL INFUZION, INC.

PI_NAMEs: GOLTZ, BRETT  (contact)

PROJECT_TITLE: DESIGN/ADAPT, DEVELOP, MAINTAIN, AND OPERATE A UNIFIED CROMS THAT SUPPORTS THE UNIQUE DATA AND CLINICAL RESEARCH PROCESS - Aging


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: ZHOU, YVONNE  (contact)

PROJECT_TERMS: Alzheimer's Disease;Data;Database Management Systems;Maintenance;Performance;Services;Systems Integration;website development

PROJECT_TITLE: PROVIDE SERVICES AND DELIVERABLES THROUGH PERFORMANCE OF TECHNICAL SERVICES SPECIFICALLY FOCUSED ON WEBSITE DEVELOPMENT, DATA/DATABASE MANAGEMENT, AND SYSTEM INTEGRATION AND MAINTENANCE


ORG_NAME: SOCIAL AND SCIENTIFIC SYSTEMS,  INC.

PI_NAMEs: BYRD-CLARK, DANITA  (contact)

PROJECT_TERMS: base;Epidemiology;Performance;Services

PROJECT_TITLE: EPIDEMIOLOGY SUPPORT TASK ORDER  - BASE YEAR  PERIOD OF PERFORMANCE, APRIL 17, 2023 - APRIL 16, 2024 AND FOUR OPTIONAL PERIODS. PROFESSIONAL SERVICES


PROJECT_TERMS: Aging

PROJECT_TITLE: NIA START-UP CHALLENGE AND ACCELERATOR INITIAL OBLIGATION


ORG_CITY: ALBUQUERQUE

ORG_NAME: LOVELACE BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: NM

PI_NAMEs: ROBERTSON, MIKE  (contact)

PROJECT_TERMS: Animals;bone;Complex;Contractor;Defect;efficacy evaluation;Fracture;Government;healing;Health Care Costs;Hospitalization;Investigation;Lower Extremity;Medical;Modeling;Morbidity - disease rate;Operative Surgical Procedures;Orthopedics;Osteogenesis;Pain;Pharmacotherapy;pre-clinical;pre-clinical research;Quality of life;Research;Research Design;sheep model;Time;United States;Upper Extremity

PROJECT_TITLE: CHARACTERIZATION OF SPONTANEOUS OSTEOGENESIS AFTER SURGICAL SEGMENTAL BONE DEFECT IN A LARGE ANIMAL


ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PI_NAMEs: BOOK, SARAH  (contact)

PROJECT_TITLE: CORE FUNCTION ACTIVITIES TASK ORDER FOR ADVISORY SERVICES AND ADMINISTRATIVE REPORTING


PI_NAMEs: DAY, ROBERT  (contact)

PROJECT_TERMS: Aging;Genomics;Precision Health

PROJECT_TITLE: ROUNDTABLE ON GENOMICS AND PRECISION HEALTH - Aging


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PI_NAMEs: SHOPTAW, STEVEN  (contact)

PROJECT_TITLE: CORE FUNCTION ACTIVITIES TASK ORDER FOR ADVISORY SERVICES AND ADMINISTRATIVE REPORTING.


ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PI_NAMEs: BRUNETTE, MARY  (contact)


ORG_CITY: WESTBROOK

ORG_STATE: ME

PI_NAMEs: COLE, JIM  (contact)

PROJECT_TERMS: aged;Aging;Monitor;Pathology;Rodent

PROJECT_TITLE: PATHOLOGY MONITORING OF AGED RODENT COLONIES


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PI_NAMEs: TIOURIRINE, NASSIMA  (contact)

PROJECT_TITLE: CORE FUNCTION ACTIVITY TASK ORDER FOR ADVISORY SERVICES AND ADMINISTRATIVE REPORTING.


PI_NAMEs: ESCOBAR URIAS, SERGIO  (contact)

PROJECT_TITLE: DEVELOPMENT AND MAINTENANCE OF A MULTIGENOTYPIC AGED MOUSE COLONY


ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

PI_NAMEs: DEVINE, ERIC  (contact)


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PI_NAMEs: BROWN, E. SHERWOOD  (contact)

PROJECT_TERMS: Advisory Services;Reporting


NIH_SPENDING_CATS: Patient Safety

ORG_CITY: NORTH BETHESDA

ORG_NAME: AXLE INFORMATICS, LLC

PI_NAMEs: MAYS, GARY  (contact)

PROJECT_TERMS: Acceleration;Clinical and Translational Science Awards;Ethical Review;Ethics;flexibility;Goals;Institutional Review Boards;Modeling;Multi-site clinical study;National Center for Advancing Translational Sciences;Process;programs;Research Personnel;Resources;Site

PROJECT_TITLE: SMARTIRB 2.0


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PI_NAMEs: HADIJAH, VACTOR  (contact)

PROJECT_TERMS: Alzheimer's Disease;clinical research site;neuroAIDS;Tissues

PROJECT_TITLE: NATIONAL NEUROHIV TISSUE CONSORTIUM (NNTC) - CLINICAL SITE - Alzheimer's disease


ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PI_NAMEs: GELMAN, BENJAMIN  (contact)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_CITY: GAITHERSBURG

ORG_NAME: FAST TRACK DRUGS AND BIOL

PI_NAMEs: RICKMAN, WILLIAM  (contact)

PROJECT_TERMS: Clinical Data;data management;Data Management Resources;Security;Update

PROJECT_TITLE: IT SECURITY UPDATE TO CLINICAL DATA MANAGEMENT SYSTEM -- CRO STUDY AND DATA MANAGEMENT


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: HYPERTHESIS, LLC

PI_NAMEs: POL, GRATIANA  (contact)

PROJECT_TERMS: Alzheimer's Disease;behavioral and social science;Small Business Innovation Research Grant;social science research;Visualization software

PROJECT_TITLE: SBIR - TOPIC 009 - AI/ML TOOL FOR VISUALIZING BEHAVIORAL AND SOCIAL SCIENCE RESEARCH


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PI_NAMEs: SIMMONS, HEATHER  (contact)

PROJECT_TITLE: DEVELOPMENT AND MAINTENANCE OF A NON-HUMAN PRIMATE TISSUE BANK


ORG_CITY: WILMINGTON

ORG_NAME: CHARLES RIVER LABORATORIES INTNTL, INC.

PI_NAMEs: URIAS, SERGIO  (contact)

PROJECT_TITLE: DEVELOPMENT AND MAINTENANCE OF A MULTIGENOTYPIC AGED RAT COLONY


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: MOUNTAIN VIEW

ORG_NAME: NEUCYTE, INC.

PI_NAMEs: POON, WAYNE  (contact)

PROJECT_TERMS: Alzheimer's Disease;high-throughput drug screening;miniaturize

PROJECT_TITLE: A MINIATURIZED AD MPS PLATFORM FOR HIGH-THROUGHPUT DRUG SCREENING


NIH_SPENDING_CATS: Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: INDIANAPOLIS

ORG_NAME: REGENSTRIEF INSTITUTE, INC.

ORG_STATE: IN

PI_NAMEs: GRANNIS, SHAUN  (contact)

PROJECT_TITLE: LINKAGE HONEST BROKER SERVICES FOR THE N3C DATA ENCLAVE


NIH_SPENDING_CATS: Clinical Research;Coronaviruses

ORG_CITY: DENVER

ORG_NAME: PALANTIR TECHNOLOGIES, INC.

PI_NAMEs: ZAVERTNIK, BRIAN  (contact)

PROJECT_TERMS: Address;Clinical;cohort;COVID-19;COVID-19 pandemic;Data;data enclave;data harmonization;Data Set;Electronic Health Record;Health;Infrastructure;Institution;Medical Research;National Center for Advancing Translational Sciences;National Security;Outcome;patient privacy;Persons;Research;Research Personnel;Resources;response;Speed;Work

PROJECT_TITLE: National Clinical Cohort Collaborative (N3C)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: HOUSTON

ORG_DEPT: CHEMISTRY

ORG_NAME: RICE UNIVERSITY

PHR: PROJECT NARRATIVE  Natural products hold a crucial role in developing novel molecular tools, such as pharmaceutical agents and probes. Specifically, they provide a major driving force for discovering new chemotherapeutics and are the primary source of compounds for the effective treatment of cancer and infectious diseases. The proposed research aims to develop new strategies and methods to prepare and study promising small bioactive molecules based on complex natural products that are not readily accessible yet would be highly desirable if brought within the realm of medicinal chemistry.

PI_NAMEs: SARLAH, DAVID  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Synthesis of Biologically Active Terpenoids

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ORG_CITY: FAIRFAX

ORG_NAME: ICF, INC., LLC

ORG_STATE: VA

PI_NAMEs: MOYER, MELINDA MOYER  (contact)

PROJECT_TERMS: Exhibits;National Institute on Alcohol Abuse and Alcoholism;Publications

PROJECT_TITLE: NIAAA PUBLICATIONS AND EXHIBITS SUPPORT


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Social Determinants of Health;Substance Misuse

ORG_CITY: BETHESDA

ORG_NAME: CDM GROUP, INC.

PI_NAMEs: HERRON, KATHERYN  (contact)

PROJECT_TERMS: alcohol policy information system;Data;Maintenance;National Institute on Alcohol Abuse and Alcoholism;Research;System;Update;web site

PROJECT_TITLE: NIAAA ALCOHOL POLICY INFORMATION SYSTEM (APIS) SYSTEM/WEBSITE MAINTENANCE AND UPDATING OF RESEARCH DATA


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Autism;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Substance Misuse

PI_NAMEs: SCHULMAN, SAMARA  (contact)

PROJECT_TERMS: Acceleration;Affect;Archives;autism spectrum disorder;biomedical informatics;Brain Diseases;Communication;Data;data archive;Data Collection;data platform;Databases;Diagnosis;flexibility;Genetic;interest;National Institute of Mental Health;Persons;Prevention;repository;Research;Retrieval;Series;System;United States National Institutes of Health;Work

PROJECT_TITLE: THE PURPOSE OF THIS TASK ORDER IS TO SUPPORT THE NATIONAL INSTITUTE OF MENTAL HEALTH (NIMH) DATA ARCHIVE (NDA) IN ACCORDANCE WITH THE INCORPORATED ATTACHMENT 1: STATEMENT OF WORK.


ORG_CITY: SEATTLE

ORG_NAME: SEABRIGHT LLC

ORG_STATE: WA

PI_NAMEs: THONGPANG, SANITTA  (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Population;Resources;Small Business Innovation Research Grant;Technology

PROJECT_TITLE: SBIR TOPIC 010 - TECHNOLOGY TO FACILITATE CHARACTERIZATION OF THE EXPOSOME IN UNDER-RESOURCED POPULATIONS FOR AD/ADRD STUDIES


ORG_CITY: Rockville

ORG_NAME: DIGITAL INFUZION, INC.

PI_NAMEs: APPELMANS, ELINE  (contact)

PROJECT_TERMS: Alzheimer's Disease

PROJECT_TITLE: TASK ORDER 1 - OCR PROJECT MANAGEMENT, DSMB AND CROMS-RELATED SUPPORT


ORG_CITY: EXETER

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY OF EXETER

ORG_ZIPCODE: EX4 4QJ

PI_NAMEs: BALLARD, CLIVE  (contact)

PROJECT_TERMS: Alzheimer's Disease;controlled release;phenserine;research clinical testing;tablet formulation;Tartrates

PROJECT_TITLE: CLINICAL EVALUATION OF PHENSERINE TARTRATE EXTENDED CONTROLLED RELEASE TABLET (ECRT) FORMULATION - Alzheimer's disease


ORG_CITY: ROCKVILLE

ORG_NAME: IQ SOLUTIONS, INC.

PI_NAMEs: BRACKETT, THOMAS  (contact)

PROJECT_TERMS: Alzheimer's Disease;Information Resources;National Institute on Aging

PROJECT_TITLE: TASK ORDER 1: NATIONAL INSTITUTE ON AGING (NIA) INFORMATION RESOURCE CENTER


ADMINISTERING_IC: AA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative Astrocytes modulate neuronal function and current evidence indicates that alcohol dependence is associated with neuronal hyperexcitability. This project will examine how ethanol impacts astrocyte regulation of neuronal excitability using a novel cell culture model of in vitro, intermittent ethanol exposure with different molecular approaches. The goal of these experiments is to identify potential drug targets for the treatment of alcohol use disorder.

PI_NAMEs: EZERSKIY, LUBOV  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Abstinence;Acute;Agonist;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol research;alcohol response;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Amyotrophic Lateral Sclerosis;Astrocytes;Automobile Driving;Brain;Buffers;candidate identification;Cell Culture Techniques;Cells;central nervous system injury;Chronic;Clinical;Coculture Techniques;Communities;Dependence;Development;Diabetic Neuropathies;differential expression;Disease;drinking;Ethanol;excitotoxicity;experimental study;Exposure to;extracellular;FOLH1 gene;Gene Expression;gene network;Genes;glutamate carboxypeptidase;Glutamate Transporter;Glutamates;Goals;Homeostasis;in vitro Model;in vivo;Induced Neurons;innovation;interest;Mediating;Mediator;Medical;Messenger RNA;metabotropic glutamate receptor 2;Microelectrodes;Modeling;Molecular;Mus;N-acetylaspartate;N-acetylaspartylglutamate;negative affect;Neuroimmune system;neuronal excitability;Neurons;Neuropeptides;neuropsychiatry;neurotransmitter release;novel;pain model;Pathway Analysis;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacologic;pinacolyl methylphosphonic acid;Play;presynaptic;Procedures;protein transport;Proteins;receptor;Regulation;Relapse;Research;Rodent;Role;Schizophrenia;Signal Transduction;social;Substance Withdrawal Syndrome;Synapses;Syndrome;targeted treatment;Testing;Therapeutic;Time;tool;Transcript;transcriptomics;treatment strategy;United States Food and Drug Administration;Withdrawal

PROJECT_TITLE: Mechanisms by which alcohol disrupts astrocytic control of neuronal excitability


ORG_CITY: MC LEAN

ORG_NAME: MITRE CORPORATION

PI_NAMEs: KUNZMAN, JON  (contact)

PROJECT_TERMS: Alzheimer's Disease;cloud based;data infrastructure;Research

PROJECT_TITLE: CLOUD-BASED RESEARCH DATA INFRASTRUCTURE - Alzheimer's disease


NIH_SPENDING_CATS: Aging;Networking and Information Technology R&D (NITRD)

PROJECT_TITLE: CLOUD-BASED RESEARCH DATA INFRASTRUCTURE - Aging


ORG_NAME: NATIONAL INSTITUTE ON AGING

PROJECT_TERMS: Alzheimer's Disease;Censuses

PROJECT_TITLE: Census - Alzheimer's disease


PROJECT_TERMS: Alzheimer's Disease;Data

PROJECT_TITLE: NIA-CMS IAA to Purchase CMS Data for NIA Grantees - Alzheimer's disease


PROJECT_TERMS: Aging;Data

PROJECT_TITLE: NIA-CMS IAA to Purchase CMS Data for NIA Grantees - Aging


PROJECT_TERMS: Alzheimer's Disease;statistics

PROJECT_TITLE: Department of Labor - Bureau of Labor Statistics NLSY


PROJECT_TERMS: Aging;aging related;statistics;United States National Center for Health Statistics

PROJECT_TITLE: CDC/NCHS - Federal Interagency Forum on Aging-Related Statistics


NIH_SPENDING_CATS: Asthma;Cardiovascular;Chronic Obstructive Pulmonary Disease;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Lung;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PI_NAMEs: CAI, JIANWEN  (contact)

PROJECT_TERMS: Accident and Emergency department;Acute myocardial infarction;Adult;aged;Ancillary Study;Asthma;asthma exacerbation;Back;Cardiovascular Diseases;Cardiovascular system;Central American;Certification;Cessation of life;Chicago;Chronic;Chronic Disease;Chronic Obstructive Pulmonary Disease;Cities;cohort;Community Participation;Contracts;Cross-Sectional Studies;Cuban;Diabetes Mellitus;Disease;Dominican;Echocardiography;Event;follow-up;Funding;Future;Goals;Health;health care service utilization;Health Status;hearing impairment;Heart Diseases;Heart failure;Hispanic;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;Hospitalization;Human Resources;Hypertension;Interview;Journals;Latino;Latino Population;Longitudinal Studies;Lung;Lung Diseases;Medical History;meetings;Mexican;mortality;neurocognitive disorder;Newly Diagnosed Disease;Obesity;Observational Study;Participant;Performance;Periodontal Diseases;Pregnancy Histories;Prevalence;prospective;protective factors;Publishing;Puerto Rican;recruit;Reproductive History;Risk;Risk Factors;Sampling;Sleep Disorders;South American;Stroke;Time;Tooth Diseases;Training;United States;Update;Visit;Woman

PROJECT_TITLE: HISPANIC COMMUNITY HEALTH STUDY-STUDY OF LATINOS (HCHS-SOL)- COORDINATING CENTER


NIH_SPENDING_CATS: Complementary and Integrative Health

ORG_CITY: WASHINGTON

ORG_NAME: NATIONAL ACADEMY OF SCIENCES

PROJECT_TITLE: FY24 IC SUPPORT FOR THE NEUROSCIENCE FORUM


PI_NAMEs: SLAUGHTER, SAMANTHA  (contact)

PROJECT_TERMS: Communication;Marketing;National Institute on Alcohol Abuse and Alcoholism;outreach;programs;Small Business Innovation Research Grant;Small Business Technology Transfer Research

PROJECT_TITLE: TO PROVIDE MARKETING AND OUTREACH FOR THE NIAAA SBIR/STTR PROGRAM TO HELP COMMUNICATE THE OBJECTIVES OF THE PROGRAM.


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_NAME: WESTAT, INC.

PI_NAMEs: CARUSI, CHARLES  (contact)

PROJECT_TERMS: Country;Health;Longitudinal Studies;Performance;Persons;Population Assessment of Tobacco and Health;Research;Tobacco;Tobacco use;United States;United States Food and Drug Administration;United States National Institutes of Health

PROJECT_TITLE: POPULATION ASSESSMENT OF TOBACCO AND HEALTH (PATH) STUDY PERIOD OF PERFORMANCE: 02/01/2024 - 01/31/2029


ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PI_NAMEs: BECKER, PH.D., HOWARD C.  (contact)

PROJECT_TERMS: alcohol use disorder;Dependence;Modeling;Pharmaceutical Preparations;pre-clinical;screening

PROJECT_TITLE: PRECLINICAL MEDICATIONS SCREENING IN DEPENDENCE MODELS OF ALCOHOL USE DISORDER


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Primary Health Care;Substance Misuse

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PI_NAMEs: WEISNER, DR.PH., MSW, CONSTANCE  (contact)

PROJECT_TERMS: Affect;Alcohol consumption;alcohol use disorder;Alcohols;California;comorbidity;Data;demographics;Development;Health;Healthcare;Pharmacy facility;Primary Care;Recovery;Registries;screening;Substance abuse problem;success

PROJECT_TITLE: KAISER PERMANENTE OF NORTHERN CALIFORNIA (KPNC) ALCOHOL REGISTRY


ORG_CITY: GAITHERSBURG

ORG_NAME: FAST TRACK DRUGS AND BIOL

PI_NAMEs: RANSOM, JANET  (contact)

PROJECT_TERMS: alcohol abuse therapy;alcohol use disorder;Clinical;Clinical Research;clinical research site;Clinical Trials;Contractor;Contracts;Data Analyses;data management;Development;electronic data;Extramural Activities;Good Clinical Practice;meetings;Monitor;National Institute on Alcohol Abuse and Alcoholism;Pharmaceutical Preparations;Preparation;Reporting;Research Contracts;Services;Shipping;Statistical Data Interpretation;treatment program;Work

PROJECT_TITLE: APREMILAST FOR THE TREATMENT OF ALCOHOL USE DISORDER -- CONTRACT RESEARCH ORGANIZATION STUDY AND DATA MANAGEMENT


PI_NAMEs: MOYER, MELINDA  (contact)

PROJECT_TERMS: Communication;National Institute on Alcohol Abuse and Alcoholism;outreach

PROJECT_TITLE: NIAAA OUTREACH AND COMMUNICATIONS SUPPORT


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Pain Research;Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PI_NAMEs: EDWARDS, SCOTT  (contact)

PROJECT_TITLE: PRECLINICAL MEDICATIONS SCREENING IN DEPENDENCE, AFFECT AND PAIN MODELS OF ALCOHOLISM


ORG_CITY: ARLINGTON

ORG_NAME: CSR, INC.

PI_NAMEs: SLATER, MEGAN  (contact)

PROJECT_TERMS: alcohol epidemiology;Information Systems;National Institute on Alcohol Abuse and Alcoholism

PROJECT_TITLE: NIAAA ALCOHOL EPIDEMIOLOGIC DATA SYSTEM (AEDS)


NIH_SPENDING_CATS: Cancer

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PI_NAMEs: BRISCOE, LYNN  (contact)

PROJECT_TERMS: anti-cancer research;Funding;Industry;Laboratories;Medical center;National Cancer Institute;National Institute of Allergy and Infectious Disease;research and development

PROJECT_TITLE: FFRDC TASK ORDER - LEASES


NIH_SPENDING_CATS: Cancer;Clinical Research

PROJECT_TITLE: FY24 FACILITIES TO A - 126615 CONVERSION OF ANIMAL ROOM


PROJECT_TITLE: FY24 FACILITIES TO C - 126610 B555 CHILLER VFD INSTALL


PROJECT_TERMS: Ensure;Location;Vestibule

PROJECT_TITLE: FY24 FACILITIES TO D - 126629 B322 INSTALL VESTIBULE AND COVERED WALKWAY


ACTIVITY: ZIA

ADMINISTERING_IC: NS

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: KHALIQ, ZAYD M (contact)

PROJECT_TERMS: Automation;Basal Ganglia;Brain;Cell Nucleus;Cells;Computer software;connectome;Custom;data acquisition;dopamine system;dopaminergic neuron;Engineering;Equipment;experimental study;Future;Goals;Grant;Intramural Research Program;Laboratories;Midbrain structure;Morphology;National Institute of Neurological Disorders and Stroke;Neurons;neurophysiology;patch sequencing;Physiology;Population;Postdoctoral Fellow;Procedures;Property;Reagent;Site;Substantia nigra structure;Testing;tool;Training;transcriptome;transcriptomics;Ventral Tegmental Area

PROJECT_TITLE: BRAIN CONNECTS: PatchLink, scalable tools for integrating connectomes, projectomes, and transcriptomes


ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Narrative Leveraging discoveries emerging from our previous R35, this proposal extends findings relevant to rewired UPR signaling affecting tumor-intrinsic (ATF4 pro- and anti-apoptotic signaling) and -extrinsic (microbiota composition and anti-tumor immunity) pathways. We propose to study these processes during aging, which provide unprecedented opportunity to study melanoma metastasis, thus offering novel paradigms to address fundamental unanswered questions in cancer biology.

PI_NAMEs: RONAI, ZEEV A. (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TITLE: Rewired Signaling at the Nexus of Melanoma Metastasis and Resistance


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PROJECT_TITLE: STRONG HEART STUDY (SHS) - COORDINATING CENTER (CC) - TASK AREA B.2 - YEAR 2


NIH_SPENDING_CATS: American Indian or Alaska Native;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Patient Safety;Racial and Ethnic Minority Health Research

ORG_CITY: HYATTSVILLE

ORG_NAME: MEDSTAR HEALTH RESEARCH INSTITUTE

PI_NAMEs: UMANS, JASON  (contact)

PROJECT_TERMS: Adverse event;American Indian community;Ancillary Study;Area;blind;Blood;Blood Volume;Cardiovascular Diseases;cardiovascular disorder epidemiology;Centrifugation;Certification;Clinic;Clinical;clinically relevant;clinically significant;cold temperature;community based research;Community Relations;Computers;Consent;Consultations;Contractor;Data;Data Analyses;data cleaning;Data Collection;data exchange;data management;Dry Ice;epidemiology study;Event;experience;follow-up;Funding;Health;Health Personnel;Heart;Human Resources;human subject;Informed Consent;Institutional Review Boards;Interview;Investigation;Laboratories;Laboratory Procedures;Lead;Measurement;Measures;Medical Staff;National Heart, Lung, and Blood Institute;operation;Participant;participant retention;Performance;Phase;Policies;Preparation;Principal Investigator;Procedures;protocol development;Protocols documentation;Qualifying;quality assurance;Quality Control;Recommendation;recruit;Refrigeration;Reporting;Research;Research Design;Research Institute;Research Personnel;Sampling;Schedule;Serious Adverse Event;Shipping;skills;Software Design;Specific qualifier value;Specimen;Training;transmission process;tribal community;Urine;Work

PROJECT_TITLE: STRONG HEART STUDY (SHS)-MEDSTAR HEALTH RESEARCH INSTITUTE- FIELD CENTER (FC), TASK AREA B.2, YEAR 2


ORG_CITY: EAGLE BUTTE

ORG_NAME: MISSOURI BREAKS RESEARCH, INC.

ORG_STATE: SD

PROJECT_TITLE: STRONG HEART STUDY (SHS)-MISSOURI BREAKS INDUSTRIES RESEARCH, INC.- FIELD CENTER (FC), TASK AREA B.2, YEAR 2


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: SCIOME, LLC

PI_NAMEs: SHAH, RUCHIR  (contact)

PROJECT_TERMS: Bioinformatics;Biometry;Contractor;Data;Data Analyses;Development;epigenomics;Experimental Designs;experimental study;Genomics;Image;In Vitro;in vivo;Informatics;Methods;National Institute of Environmental Health Sciences;Quality Control;Quantitative Structure-Activity Relationship;Review Literature;screening;Support Contracts;text searching;Toxicogenomics;transcriptomics

PROJECT_TITLE: BIOINFORMATICS SUPPORT FOR DNTP & DIR


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PROJECT_TERMS: Bioinformatics;Biometry;Chemicals;Contractor;Data;Development;epigenomics;Experimental Designs;Genomics;high throughput screening;Image;In Vitro;Informatics;Methods;model building;National Institute of Environmental Health Sciences;predictive modeling;Quantitative Structure-Activity Relationship;Review Literature;Support Contracts;Testing;text searching;tool;Toxicogenomics;Toxicology;transcriptomics;user-friendly;Validation


NIH_SPENDING_CATS: Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Bioinformatics;Biometry;Cells;Classification;Collaborations;Contractor;Data;Development;epigenomics;Experimental Designs;Genomics;Hazard Assessment;Image;Image Analysis;Informatics;Machine Learning;Methods;Morphology;National Institute of Environmental Health Sciences;Quantitative Structure-Activity Relationship;Review Literature;Support Contracts;text searching;Toxic effect;Toxicogenomics;transcriptomics;Whole Organism;Zebrafish


NIH_SPENDING_CATS: Clinical Research;Pediatric;Pregnancy

ORG_CITY: SILVER SPRING

ORG_NAME: SOCIAL AND SCIENTIFIC SYSTEMS,  INC.

ORG_STATE: MD

PI_NAMEs: JACKSON, BRAXTON  (contact)

PROJECT_TERMS: Age;Biological Markers;Chemical Exposure;Child;Childhood;cohort;Data;fetal;First Pregnancy Trimester;follow-up;Generations;Growth;Growth and Development function;Individual;Inflammation;insight;Longterm Follow-up;Measurement;Measures;metabolome;metabolomics;National Institute of Environmental Health Sciences;Outcome;Participant;Pathway interactions;Pattern;Physiological;Plasma;Pregnancy;prenatal;prospective;research and development;Sampling;Second Pregnancy Trimester;Time;Umbilical Cord Blood

PROJECT_TITLE: TASK ORDER NO.: 75N96024F00024 RESEARCH DEVELOPMENT - GENR METABOLOMICS STUDY DATA SUPPORT


PROJECT_TERMS: Bioinformatics;Biometry;Carcinogens;Data;Development;epigenomics;Experimental Designs;Genomics;Image;Informatics;Maps;Methods;National Institute of Environmental Health Sciences;Quantitative Structure-Activity Relationship;Reporting;Review Literature;Support Contracts;systematic review;text searching;tool;Toxicogenomics;transcriptomics


PROJECT_TERMS: Bioinformatics;Biometry;Contractor;Data;Databases;Development;epigenomics;Experimental Designs;Genomics;Image;Informatics;Methods;National Institute of Environmental Health Sciences;Quantitative Structure-Activity Relationship;Resources;Review Literature;Support Contracts;text searching;tool;Toxicogenomics;transcriptomics;Update


PROJECT_TERMS: Amendment;Animal Experiments;Authorization documentation;clinical translation;data submission;Development;Education;Engineering;experimental study;Future;Human;neuroregulation;novel;Peripheral;Phase;Prize;Rewards;Science;Scientist;Technology;United States National Institutes of Health

PROJECT_TITLE: OD SPARC NEUROMOD CHALLENGE PRIZE PHASE 3 OBLIG


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Burden of Illness;Cancer;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Services;Infectious Diseases;Orphan Drug;Ovarian Cancer;Palliative Care;Prevention;Prostate Cancer;Radiation Oncology;Rare Diseases;Urologic Diseases;Women's Health Research

ORG_CITY: HARTFORD

ORG_NAME: CONNECTICUT STATE DEPT OF PUBLIC HEALTH

ORG_STATE: CT

PI_NAMEs: GONSALVES, MARYLOU  (contact)

PROJECT_TERMS: 20 year old;Adjuvant Therapy;Adopted;Affect;Age;American Cancer Society;Area;Beds;Biological Markers;cancer care;cancer diagnosis;Cancer Patient;cancer recurrence;cancer therapy;Characteristics;chemotherapy;clinical practice;Communities;comorbidity;Congresses;Consensus;COVID-19 pandemic;COVID-19 pandemic effects;Data;Diagnosis;Diagnostic tests;Division of Cancer Control and Population Sciences;Documentation;Educational process of instructing;Ethnic Origin;Geographic Locations;Guidelines;Healthcare Systems;hormone therapy;Hospitals;Immunotherapy;Incidence;Individual;Inpatients;Insurance Coverage;Knowledge;Laws;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;Medical Records;National Cancer Institute;Neoplasm Metastasis;Newly Diagnosed;Operative Surgical Procedures;Outpatients;Palliative Care;pandemic potential;Patient Care;Patients;Pattern;Patterns of Care;Physicians;Physicians' Offices;Race;Radiation therapy;Recommendation;Records;Reporting;Screening for cancer;sex;Systemic Therapy;targeted treatment;Testing;Time;treatment pattern;United States;Update;working group

PROJECT_TITLE: NCI PATTERNS OF CARE STUDY- DIAGNOSIS YEAR 2021 (PROSTATE CANCER AND OVARIAN CANCER)


PI_NAMEs: MANISCALCO, LAUREN  (contact)

PROJECT_TITLE: NCI PATTERNS OF CARE STUDY FY24 - DIAGNOSIS YEAR 2021 (PROSTATE CANCER AND OVARIAN CANCER)


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PI_NAMEs: DOHERTY, JENNIFER A. (contact)

PROJECT_TITLE: NCI PATTERNS OF CARE STUDY FOR DIAGNOSIS YEAR 2021 (PROSTATE CANCER AND OVARIAN CANCER)


ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PI_NAMEs: WEST, MICHELE  (contact)

PROJECT_TITLE: NCI PATTERNS OF CARE STUDY - DIAGNOSIS YEAR 2021 (PROSTATE CANCER AND OVARIAN CANCER)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PI_NAMEs: MIRANDA, ROBERT  (contact)

PROJECT_TITLE: CORE FUNCTION ACTIVITIES TASK ORDER FOR ADVISORY SERVICES AND ADMINISTRATIVE REPORTING


ORG_CITY: OAKLAND

ORG_NAME: PUBLIC HEALTH INSTITUTE

ORG_STATE: CA

PI_NAMEs: SHRESTHA, ANSHU  (contact)

PROJECT_TITLE: NCI PATTERNS OF CARE STUDY-DIAGNOSIS YEAR 2021 (PROSTATE CANCER AND OVARIAN CANCER)


ORG_CITY: BIRMINGHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Latinas suffer more perioperative complications that their non-Hispanic peers when undergoing urogynecologic surgery, in part, because of lower surgical preparedness. Prior studies to increase surgical preparedness have been conducted mostly on White women, excluded non-English speakers, and not cost-effective nor practical. The proposed research will use human centered design and dissemination and implementation methods to center stakeholder input to develop a usable and sustainable intervention that considers the cultural and societal needs of Latina patients and their clinical environments, an approach not used thus far in the development and testing of other surgical preparedness interventions.

PI_NAMEs: HALDER, GABRIELA E. (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TITLE: A Telehealth Intervention to Increase Patient Preparedness for Surgery in Latinas

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PI_NAMEs: SCHWARTZ, STEPHEN M (contact)


ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PI_NAMEs: DURBIN, ERIC  (contact)


NIH_SPENDING_CATS: Aging;Cancer;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Ovarian Cancer;Palliative Care;Prevention;Prostate Cancer;Rare Diseases;Urologic Diseases;Women's Health Research

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PI_NAMEs: WIGGINS, CHARLES  (contact)

PROJECT_TITLE: NCI PATTERNS OF CARE (POC) STUDY: DIAGNOSIS YEAR 2021 (PROSTATE CANCER AND OVARIAN CANCER)


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Microbiome;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_NAME: MIDWEST RESEARCH INSTITUTE

ORG_STATE: MO

PI_NAMEs: WHITE, JON  (contact)

PROJECT_TERMS: Atopobium vaginae;Bacterial Vaginosis;Biological Response Modifier Therapy;Cervical dysplasia;Clinical;Clinical Trials;dysbiosis;Lactobacillus;Malignant neoplasm of cervix uteri;microbiota;Pharmaceutical Preparations;Placebos;Production;Risk;Vagina;vaginal microbiota;Woman

PROJECT_TITLE: THE SCOPE OF THIS TASK ORDER IS (1). PRODUCTION OF A DRUG SUBSTANCE, (2) CONVERSION OF DRUG SUBSTANCE TO DRUG PRODUCT, (3) FILLING DRUG PRODUCT INTO APPLICATORS TO BE USED IN THE CLINICAL TRIALS, AND


NIH_SPENDING_CATS: Cancer;Immunization;Vaccine Related

PI_NAMEs: GINTHER, RACHEL  (contact)

PROJECT_TERMS: Antigens;Buffers;cell bank;Cells;Cyclic GMP;Development;DNA Vaccines;drug production;Elements;Engineering;Environment;Fermentation;follow-up;Guidelines;Human;manufacture;next generation sequencing;Pharmaceutical Preparations;plasmid DNA;Plasmids;Process;research and development;Running;screening;System;Vaccine Production;Work

PROJECT_TITLE: MANUFACTURE OF PLASMID DNA DRUG SUBSTANCE AND DRUG PRODUCT


ORG_CITY: WASHINGTON

ORG_STATE: DC

PI_NAMEs: KLEIN, AMANDA  (contact)

PROJECT_TERMS: Cancer health equity;design;Educational workshop;meetings;Persons;Series;service coordination;virtual

PROJECT_TITLE: COORDINATION FOR THE CANCER HEALTH EQUITY DESIGN LAB WORKSHOP


NIH_SPENDING_CATS: Cancer;Clinical Research;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MADISON

ORG_NAME: WISCONSIN DEPARTMENT OF HEALTH SERVICES

ORG_STATE: WI

PI_NAMEs: WERNER, MARK ALLAN (contact)

PROJECT_TERMS: Area;Data;data exchange;Data Linkages;data management;Malignant Childhood Neoplasm;Malignant Neoplasms;neoplasm registry;programs;Registries;Research;Research Activity;Research Support;SEER Program;surveillance data;trend;virtual;young adult

PROJECT_TITLE: SEER RESEARCH SUPPORT REGISTRIES PROGRAM LINKAGES AND DATA MANAGEMENT SUPPORT


ORG_CITY: DENVER

ORG_NAME: COLORADO STATE DEPT/PUB HLTH & ENVIRONMT

ORG_STATE: CO

PI_NAMEs: AREND, JOHN  (contact)


ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PI_NAMEs: BRISCOE, LYNN  (contact)

PROJECT_TITLE: ARPA-H BIOMEDICAL DATA FABRIC TOOLBOX PROGRAM


ORG_CITY: NASHVILLE

ORG_NAME: TENNESSEE STATE DEPARTMENT OF HEALTH

ORG_STATE: TN

PI_NAMEs: WHITESIDE, MARTIN  (contact)

PROJECT_TITLE: SEER RESEARCH SUPPORT REGISTRIES PROGRAM AND LINKAGES AND DATA MANAGEMENT SUPPORT


PROJECT_TERMS: anti-cancer research;Funding;Industry;Laboratories;National Cancer Institute;National Institute of Allergy and Infectious Disease;research and development

PROJECT_TITLE: FY24/FY25 FFRDC LEASES OPERATIONAL TASK ORDER


NIH_SPENDING_CATS: Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

PROJECT_TERMS: Biological Assay;Biological Products;cell bank;Chemistry;Clinical Research;Development;Engineering;Evaluation;GMP lots;Human;Logistics;manufacture;Pharmaceutical Preparations;Process;Qualifying;Records;Spinal cord injury;System;Vial device;Work

PROJECT_TITLE: NEURESTA DRUG SUBSTANCE MANUFACTURING


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research

PROJECT_TERMS: Affinity;Antibodies;Antibody Formation;base;Biological Assay;cancer type;Clinical Trials;Communities;Complement;cost;Data;Deposition;Development;Ensure;Generations;Guidelines;Hybridomas;Individual;Length;Measurement;metabolomics;Methodology;Methods;Modification;Monoclonal Antibodies;Mus;Oryctolagus cuniculus;Peptides;pre-clinical research;Production;Proteins;Proteomics;Reagent;Reproducibility;Research;Sampling;Specific qualifier value;Standardization;Ubiquitin;United States National Institutes of Health;Work

PROJECT_TITLE: PROTEOMIC AND ANTIBODY PRODUCTION AND CHARACTERIZATION


PROJECT_TITLE: FY24 FACILITIES TO B - 126598 B560 DRAIN DOWN TANK REPLACEMENT


PROJECT_TERMS: Equipment;Immunocompromised Host;Work

PROJECT_TITLE: WORK ORDER 126643 B539 EXPAND IC SUITE


PROJECT_TITLE: FY24 FACILITIES TO E - W2F2 CCR AQUATICS FACILITY EXPANSION AND OFFICES ROOMS


PROJECT_TERMS: Biology;Chemicals;Laboratories

PROJECT_TITLE: FY24 FACILITIES TASK ORDER G B376 RENOVATE ROOMS 204-207


PROJECT_TITLE: FACILITIES TASK ORDER F - BUILDING 539 ROOMS 49-51 RENOVATIONS.


PROJECT_TERMS: Air;Floor

PROJECT_TITLE: TO-I BUILDING 1021 2ND FLOOR AHU REPLACEMENT


PROJECT_TERMS: Biological Assay;Clinical;clinical development;Clinical Trials;complex data;Data;data centers;Data Commons;data harmonization;data infrastructure;data ingestion;data integrity;data modeling;Data Set;data sharing;data tools;Development;diverse data;Ensure;Immunologic Monitoring;Immunologics;Immunooncology;improved;Maintenance;Malignant Neoplasms;Maps;operation;outreach;Preparation;Publishing;Research Personnel;Specimen;Standardization;Validation

PROJECT_TITLE: CLINICAL AND TRANSLATIONAL DATA COMMONS (CTDC) AND IMMUNE ONCOLOGY DATA HARMONIZATION/MAPPING (IODH/M)


PROJECT_TITLE: FY24 FACILITIES TO J  ATRF BDP FACILITY IMPROVEMENTS


NIH_SPENDING_CATS: Cancer

ORG_STATE: WA

PI_NAMEs: SCHWARTZ, STEPHEN  (contact)

PROJECT_TERMS: abstracting;Area;Award;base;Cancer Hospital;cancer registrars;Code;college;Contracts;Data Collection;Educational Curriculum;Exercise;Forms Controls;Guidelines;Hospital Registrar;improved;Logic;Maintenance;Mentors;Mentorship;National Cancer Program;neoplasm registry;programs;Registries;Reporting;Resources;response;SEER Program;Services;Students;Support Contracts;teacher;Testing;Training;Update

PROJECT_TITLE: SEER*EDUCATE BASE AWARD