NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Lymphatic Research;Regenerative Medicine

PHR: Thorp Narrative Lay Suboptimal inflammatory responses in the heart are characteristic of a diverse array of pathologies, including cardiac injury and cardiometabolic heart failure. Common to these pathologies is activation of myeloid phagocytes, which due to their heterogeneity and plasticity, have the capacity to either promote or resolve inflammation through cellular crosstalk. This proposal will identify novel regulatory pathways in macrophage subsets that causally modify cardiac inflammation.

PI_NAMEs: THORP, EDWARD BENJAMIN (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Acute;Affect;Age;Anti-Inflammatory Agents;Area;Basic Science;Bioenergetics;Biological Markers;Biology;Cardiac;cardiac repair;cardiometabolism;cardioprotection;Caring;Cells;Cellular Metabolic Process;Characteristics;Clinical;clinically relevant;Complement;coronary fibrosis;cytokine;Data;Diet;Disease Outcome;Disease Progression;Grant;healing;Health;Heart;heart cell;Heart failure;Heart Injuries;Heterogeneity;Hypertension;Hypoxia;Immune;immune function;Immune response;Impairment;improved;in vivo;Inflammation;Inflammatory Response;injured;Innate Immune System;insight;Intervention;Ischemia;Knock-out;Knowledge;Laboratories;Learning;Link;Lymphangiogenesis;Lymphatic;Macrophage;Metabolic;Metabolism;Mitochondria;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;Myelogenous;Myocardial;myocardial hypoxia;Myocardial Infarction;myocardial injury;Myocarditis;Nature;novel;Outcome;Pathology;Pathway interactions;percutaneous coronary intervention;Performance;Phagocytes;Phenotype;Precision therapeutics;receptor;recruit;Regulatory Pathway;repaired;Reperfusion Therapy;Resolution;Respiration;respiratory;response;Risk Factors;Role;Sampling;selective expression;sex;Signal Induction;Signal Pathway;Signal Transduction;Signaling Molecule;Stress;Testing;Therapeutic;tissue repair;Tissues;transcription factor;Transforming Growth Factor beta;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factor Receptor-3;Vascular Endothelial Growth Factors

PROJECT_TITLE: Efferocytosis-Directed Inflammation Resolution and Repair in the Hypoxic Heart

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE / RELEVANCE Intimate partner violence (IPV) and child maltreatment (CM) commonly co-occur with substance use (SU) and this trifecta of problems represents significant and preventable public health issues impacting millions of families each year in the United States. This randomized trial will provide evidence for the efficacy of an integrated fatherhood focused approach to SU, IPV and CM that can be delivered in outpatient substance use treatment settings. An integrated approach that can reduce SU, IPV and CM in one model that is easily exportable to SU treatment facilities will improve physical and mental health outcomes for fathers, mothers and children.

PI_NAMEs: STOVER, CARLA S (contact)

PROGRAM_OFFICER_NAME: AKLIN, WILL

PROJECT_TERMS: Address;Aftercare;Behavior;Child;Child Abuse and Neglect;Childhood;Client;Communication;Communities;community setting;comparative efficacy;Counseling;court;Criminal Justice;design;Development;Dose;effective intervention;effectiveness testing;efficacy testing;emotion dysregulation;emotion regulation;emotional experience;Emotions;Enrollment;evidence base;experience;Exposure to;Failure;Family;Family Violence;father child interaction;Father-Child Relations;fatherhood;Fathers;follow-up;improved;improved outcome;Individual;Intervention;intimate partner violence;Learning;male;Manuals;Mediating;men;Men's Role;Mental Health;Modeling;Mothers;Motivation;novel;Outcome;Outpatients;Parents;Participant;Persons;Pharmaceutical Preparations;physical conditioning;post intervention;Preparation;Principal Investigator;programs;Psychotherapy;Public Health;randomized trial;Recording of previous events;reduced substance use;Relapse;Reporting;Research;Risk;Role;Sampling;Site;skills;substance misuse;substance use;Substance Use Disorder;substance use treatment;success;Testing;treatment center;Treatment Efficacy;treatment group;Treatment outcome;treatment program;United States;Veterans;Violence;Woman

PROJECT_TITLE: Substance Misuse and Family Violence Treatment for Fathers

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative The Gordon Research Conference on Endothelial Cell Phenotypes in Health and Disease, and its associated Gordon Research Seminar for trainees, will facilitate knowledge sharing on basic mechanisms of endothelial cell heterogeneity and new approaches for vascular repair and regeneration. This relatively small meeting with about 140 attendees is designed to foster networking and exchange of unpublished data to jump-start collaborations that can move the field forward, with a focus on important basic science questions and tackling urgent health issues related to vascular biology.

PI_NAMEs: HLA, TIMOTHY TUN (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Academia;Acceleration;Address;Affect;Aging;Area;Basic Science;bioimaging;Biological;Biology;Biomedical Engineering;Biotechnology;Blood;Blood Vessels;career;Cells;Cellular biology;Clinical;clinical practice;Collaborations;Collection;Communication;Data;demographics;design;Development;Discipline;Disease;Disease Progression;Endothelial Cells;Ensure;Equilibrium;experience;Exposure to;Extracellular Matrix;Female;Fostering;Funding;Future;Gender;Genomic approach;Geography;Goals;Government;Health;healthspan;Heterogeneity;Homeostasis;Human;Image;improved;Industry;Institution;interdisciplinary collaboration;International;Joints;Knowledge;knowledge integration;life span;Lymphatic;lymphatic vessel;mechanical force;mechanical stimulus;meetings;Minority;Modeling;Molecular;Molecular Biology;Natural regeneration;novel;novel strategies;Organ;Participant;Pathology;Peer Group;Phenotype;Physiology;Postdoctoral Fellow;pre-doctoral;regeneration potential;regenerative;Regenerative Medicine;Regulation;repaired;Research;Research Personnel;response;Scientist;Signal Pathway;Signal Transduction;Site;social;sound;Spain;Specific qualifier value;Structure;Students;symposium;Technology;Therapeutic;Tissue Engineering;tissue regeneration;tissue repair;Tissues;tool;Translations;United States National Institutes of Health;Vascular Diseases;Vascular Endothelial Cell;Vascular regeneration;Vascularization;willingness

PROJECT_TITLE: 2024 Endothelial Cell Phenotypes in Health and Disease Gordon Research Conferences

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (J2)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics

PHR: Project Narrative This proposal seeks funding for the 2024 Gordon Research Conference on Meiosis and the associated Gordon Research Seminar on Meiosis. Meiosis is the specialized cell division used to make gametes, like oocytes and sperm. Errors in meiosis are responsible for the high levels of miscarriage and chromosomal disorders (e.g., Down syndrome) in humans.

PI_NAMEs: SEKELSKY, JEFF J. (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Acceleration;Address;Architecture;Biological;Biological Models;biophysical analysis;career;catalyst;Cell Cycle;Cell Cycle Checkpoint;Cell Cycle Regulation;Cell division;Cells;Cellular biology;Chromatin;chromosome movement;Chromosome Pairing;Chromosomes;Collaborations;college;Communities;comparative;Congenital Abnormality;Congenital chromosomal disease;Data;Dedications;Defect;Discipline;DNA Repair;Down's Syndrome;Edward's syndrome;Ensure;Environment;Epigenetic Process;Ethnic Origin;Eukaryota;Europe;Event;experience;faculty mentor;fascinate;Fostering;Functional disorder;Funding;Gender;Gene Expression;Gene Expression Regulation;Genetic Recombination;genome editing;Germ Cells;Goals;graduate student;Growth;Haploidy;Hi-C;Hour;Human;improved;Infertility;Institution;International;Investigation;Learning;London;Malignant Neoplasms;mathematical model;meetings;Meiosis;Meiotic Recombination;member;Mentors;Mentorship;Minority;model organism;Modeling;Molecular;Nature;North America;novel;Oocytes;Participant;peer;Postdoctoral Fellow;posters;Process;Production;professor;programs;Race;Regulation;Research;Research Personnel;Running;Science;segregation;Sexual Reproduction;sperm cell;Spontaneous abortion;success;superresolution microscopy;symposium;Technology;theories;Time;trend;undergraduate student;Underrepresented Minority;Underrepresented Populations;Variant;Woman;Work

PROJECT_TITLE: 2024 Meiosis Gordon Research Conference and Seminar

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Dissemination and Implementation Research;Infectious Diseases;Prevention;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Research Training in Integration of Epidemiology and Implementation  Science for Neglected Zoonotic Disease Control in Peru NARRATIVE Neglected Zoonotic Diseases (NZDs) disproportionately affect poor communities, are still frequent in most of the world, and have a catastrophic impact on the affected individuals and their families. Even though NZDs are frequently introduced into high-income countries representing a significant cost for their health systems, this group of diseases does not represent an important market for pharma and does not attract the same attention as emerging diseases, resulting in few training programs devoted to their study. This D43 application will develop and establish an innovative training program in implementation science applied to NZDs in Peru that is focused on selecting trainees from underserved areas, leveraging existing coursework, providing networking opportunities and hands-on training through identified research projects related to implementation science and NZDs, and applying our training philosophy to build a new cadre of young, committed, and talented researchers to get us closer to the targets established by the WHO Road Map for ending Neglected Tropical Diseases.

PI_NAMEs: BUSTOS, JAVIER A;CASTILLO NEYRA, RICARDO  (contact);PAZ-SOLDAN, VALERIE ANDREA

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Affect;Area;Clinical;Collaborations;Communicable Diseases;Communities;Country;Disadvantaged;Disease;disorder control;Doctor of Philosophy;Epidemiologist;Epidemiology;experience;Faculty;Family;Goals;Grant;Health;health inequalities;Health system;implementation science;improved;Income;Individual;innovation;Institution;Intervention;Latin America;medical schools;migration;Mission;neglect;neglected tropical diseases;Pennsylvania;Peru;Peruvian;Philosophy;Policies;Principal Investigator;programs;Public Health Schools;Research;Research Design;Research Project Grants;Research Training;Scientist;skills;Students;tool;Training;Training Programs;Travel;Tropical Disease;Tropical Medicine;Universities;Zoonoses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-D (55)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

ORG_STATE: NY

PHR: The goals of this R01 are to elucidate the neural circuitry mechanisms underlying lost empathy, arguably the most distressing and defining feature of frontotemporal dementia (FTD), a leading form of presenile dementia, using newly established behavioral paradigms and bvFTD mouse models. Successful completion of the proposed experiments will fill a longstanding and critical gap in our understanding of the neural basis of empathy loss associated with behavioral variant FTD and uncover novel therapeutic strategies for FTD and related dementia.

PI_NAMEs: YAO, WEI-DONG  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Accounting;Adopted;Affect;Afferent Pathways;Age;aged;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Anterior;Atrophic;Attenuated;Behavior;Behavioral;behavioral impairment;Behavioral Mechanisms;Behavioral Paradigm;Behavioral Symptoms;behavioral variant frontotemporal dementia;C9FTD;C9ORF72;calmodulin-dependent protein kinase II;Cell Physiology;cerebral atrophy;Dementia;Distress;Efferent Pathways;Elderly;Electrophysiology (science);Emotions;Empathy;excitatory neuron;Exhibits;experimental study;family burden;FDA approved;frontal lobe;Frontotemporal Dementia;Genes;Genetic;Genetic Heterogeneity;Goals;hippocampal pyramidal neuron;Homologous Gene;Human;Hypothalamic structure;Impairment;in vivo;insight;interdisciplinary approach;Judgment;Link;Maps;Mediating;Membrane;Mental disorders;Modeling;Molecular;mouse model;Mus;Mutant Strains Mice;Mutation;Nature;Nervous System Disorder;neural;neural circuit;Neurodegenerative Disorders;neuromechanism;neuronal excitability;Neurons;neuropathology;neurophysiology;novel;novel therapeutic intervention;Onset of illness;optogenetics;Oxytocin;paraventricular nucleus;Pathogenicity;Pathology;Personality;Pharmacology;Play;Prefrontal Cortex;Presenile Dementia;prevent;psychiatric symptom;social;Structure of paraventricular nucleus of thalamus;Synapses;Temporal Lobe;Testing;Therapeutic;Touch sensation;Transgenic Mice;Transgenic Organisms;treatment strategy;Variant;Wild Type Mouse

PROJECT_TITLE: Neural Mechanisms of Empathy Loss in Frontotemporal Dementia

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Atherosclerosis;Kidney Disease

ORG_CITY: CORAL GABLES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE The accumulation of fat inside of podocytes, which are key cells of the kidney filter, is an important event that contributes to progression of kidney disease. With this application, we propose to investigate how deficiency of a protein named Apolipoprotein M (APOM) affects fat content and utilization in podocytes, contributes to the leakage of protein into the urine and we aim at understanding if patients with deficiency of APOM are at higher risk for the progression of kidney disease. The strength of this proposal lies in the innovative idea on how this protein modulates fat content in the kidney, how it can be utilized to identify patients at risk, and how replacement of the deficient protein can cure kidney disease in experimental models

PI_NAMEs: TOLERICO, MATTHEW ROBERT (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Address;Affect;Albumins;antagonist;Apolipoproteins;Apoptosis;Binding;Biological Markers;Biology;career;career development;Cell Survival;Cholesterol;Circulation;clinical application;clinical development;cohort;Complex;Data;Development Plans;Devices;disease model;Enrollment;Ensure;Enzymes;Event;Exhibits;Experimental Models;Extravasation;Fatty acid glycerol esters;Gene Expression Profile;Genotype;Goals;Grant;Hereditary nephritis;High Density Lipoproteins;high risk;Human;Impairment;In Vitro;Injections;Injury;innovation;interest;Kidney;kidney cell;Kidney Diseases;Kidney Failure;Knockout Mice;Knowledge;lipid metabolism;lipidomics;Lipids;Lipoproteins;Liquid substance;Mentors;Metabolic Diseases;Metabolism;migration;Molecular;Molecular Chaperones;mouse model;mRNA Expression;Mus;Mutation;Names;Nephrotic Syndrome;novel therapeutics;outcome prediction;overexpression;particle;Pathway interactions;Patients;Pattern;Phenotype;Physiological Processes;Plasma;podocyte;prevent;progression risk;Proliferating;Protein Deficiency;Proteins;Proteinuria;Proteomics;Recombinants;Renal glomerular disease;Research;Research Proposals;reverse cholesterol transport;Risk;Role;Signal Transduction;Sphingolipids;Sphingosine;sphingosine 1-phosphate;sphingosine-1-phosphate lyase;Sphingosine-1-Phosphate Receptor;SPHK1 enzyme;success;Therapeutic;Therapeutic Effect;translational approach;translational study;United States;Urine

PROJECT_TITLE: The contribution of the APOM/S1P signaling axis to podocyte injury

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Kidney, Urology, and Hematology[DDK-G]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: MEMPHIS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MEMPHIS

ORG_STATE: TN

PHR: 8. Project Narrative Transgender and gender diverse (TGD) individuals experience disproportionate rates of trauma and mental health problems, including risky alcohol use and alcohol use disorders. Relatively little work has been done to adapt, evaluate, or implement evidence-based interventions with TGD populations. The proposed mixed methods study will identify key preferences of TGD individuals with risky alcohol use to inform future efforts to adapt evidence-based interventions and increase help-seeking and treatment efficacy in this population.

PI_NAMEs: COLGONIS, HANNAH ELISABETH (contact)

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: acceptability and feasibility;Adaptation research;Address;Adult;aged;alcohol abuse therapy;alcohol consequences;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol research;alcohol use disorder;Area;binge drinking;Buffers;cisgender;Communities;Coping Skills;culturally appropriate intervention;Data;design;Discrimination;Disparity;distrust;diversity and inclusion;Dropout;evidence base;Evidence based intervention;experience;experimental study;Fellowship;Focus Groups;Funding;Future;gender diverse;Goals;Health;health disparity;Health Personnel;Health Services Accessibility;Healthcare;help-seeking behavior;improved;Individual;interest;Intervention;Knowledge;Length;Lesbian Gay Bisexual Transgender Queer;Life Experience;Literature;Location;marginalized population;meetings;member;Mental Health;Mentorship;Methodology;Methods;minority stress;minority stressor;National Institute on Alcohol Abuse and Alcoholism;National Research Service Awards;Outcome;Participant;Pathway interactions;peer;people of color;Persons;Phase;physical conditioning;Population;Population Heterogeneity;pre-doctoral;preference;prospective;Provider;Recommendation;recruit;Reporting;Research;Research Methodology;Research Priority;resilience factor;Sampling;service providers;Services;skill acquisition;skills;social;Stress;substance use;Suggestion;Surveys;System;Techniques;theories;Training;transgender;transphobia;Trauma;Treatment Efficacy;uptake;Work

PROJECT_TITLE: A Mixed Methods Study to Enhance Alcohol Treatment Help-seeking and Engagement Among Gender Diverse Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


ORG_CITY: STANFORD

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative: Microbial metabolites have shown promise in the treatment of immune system disorders. I propose to use cutting- edge technologies to identify novel microbial metabolites and understand their mechanism of action within the host, which will shepherd the development of new medicines.

PI_NAMEs: ROBINSON, ELEKTRA KANTZARI (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: 5-hydroxy-tryptophan;absorption;Acids;Acute;Acute Disease;Address;Affect;Animal Model;Anti-Inflammatory Agents;Biochemical Pathway;Biochemistry;Biology;Calibration;career;Cell Line;cell type;Cells;Chemical Structure;chemically induced colitis;Chemicals;Chronic;Circulation;Colonic inflammation;comparative genomics;CRISPR interference;CRISPR/Cas technology;Cues;Data;Development;Diabetes Mellitus;Dietary Fiber;Dietary Intervention;Disease;DNA Sequence Alteration;Ecosystem;Enzyme-Linked Immunosorbent Assay;experience;experimental study;Fermentation;Fluorescence;G-Protein-Coupled Receptors;gain of function;Genes;Genetic;Genomic approach;Gnotobiotic;gut dysbiosis;gut inflammation;gut microbiota;Health;Histology;Homeostasis;host microbiota;host-microbe interactions;Human;Human Biology;humanized mouse;Immune;Immune response;Immune system;Immune System Diseases;Immunologics;immunoregulation;In Vitro;in vivo;Individuality;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inflammatory marker;interdisciplinary approach;Interleukin-1 beta;Intervention Studies;Intestines;Knock-in;Knock-out;Knowledge;Learning Skill;Libraries;Location;Macrophage;Malignant Neoplasms;Measures;Medicine;Mentors;Metabolic Pathway;metabolomics;Microbe;microbial;Microbial Genetics;microbial host;microbiota;microorganism;Modeling;Molecular;Molecular Genetics;mouse model;Mus;non-alcoholic fatty liver disease;novel;Nutrient;Pathway interactions;Persons;Precision therapeutics;prevent;Production;Property;Proteins;Publishing;receptor;Regulatory Pathway;Reporter;Research;Research Personnel;Role;Series;Signal Transduction;Signaling Molecule;small molecule;Syndrome;System;Technology;Testing;Tissues;TNF gene;tool;Training;translational pipeline;Universities;Volatile Fatty Acids;Work

PROJECT_TITLE: Understanding mechanisms by which microbially derived metabolites regulate host gut inflammation.

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The relationships between the words that toddlers know predict later language outcomes including vocabulary size and speed of word recognition. The proposed project will advance our understanding of how toddlers use environmental context as a cue to establish these semantic relationships between words and examine how individual differences in this process might be related to differences in toddlers’ vocabularies. Findings will inform theories of word learning and semantic development as well as provide insights into possible intervention targets to improve language development outcomes.

PI_NAMEs: BREITFELD, ELISE C (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TITLE: The Role of Environmental Context in Early Semantic Network Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_DEPT: VETERINARY SCIENCES

PHR: PROJECT NARRATIVE Frontotemporal dementia (FTD) is an Alzheimer’s disease-related dementia that has been linked to mutations in the gene encoding for the neuronal protein tau (MAPT). This project will study this disease in stem cell-derived neurons from skin cells of patients and rhesus monkeys carrying the same naturally-occurring FTD-related mutation (MAPT R406W). The direct comparison of human and monkey cells will allow us to validate the monkey cells as an in vitro model of FTD, understand pathological mechanisms across primate species, identify disease biomarkers, and ultimately, test potential new treatments before preclinical testing in the valuable monkeys for studies aimed at human clinical trials.

PI_NAMEs: COLWELL, JULIA CLAIRE (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Affect;Age;Age Years;aged;Alzheimer's disease related dementia;Animal Experimentation;Animal Model;Animals;Atrophic;autosome;Axon;Behavioral;Binding;Biological Assay;Biological Markers;biomarker identification;Brain;brain volume;Calcium;Cell Line;Cells;Clinical Trials;CRISPR/Cas technology;Dementia;Development;differential expression;Disease;Ethics;Evaluation;Family;Female;Fibroblasts;frontal lobe;Frontotemporal Dementia;Future;Gene Expression Profile;Gene Expression Regulation;gene repression;Genes;Gliosis;Heterozygote;Homeostasis;Human;Human Cell Line;human disease;Image;Impairment;In Vitro;in vitro Model;in vivo;in vivo Model;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;innovation;insight;Intracellular Transport;Language Disorders;Letters;Link;link protein;Lobe;Macaca mulatta;Magnetic Resonance Imaging;male;MAPT gene;member;Memory Loss;Methods;Microtubule Stabilization;Microtubules;Missense Mutation;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Monkeys;mood symptom;motor symptom;mutant;Mutation;mutation carrier;Nerve Degeneration;nerve stem cell;Neurobehavioral Manifestations;neuron development;neuron loss;Neuronal Differentiation;Neurons;neuropathology;nonhuman primate;novel therapeutics;Organism;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Personality;Phenotype;Point Mutation;Positron-Emission Tomography;Preclinical Testing;Primates;Process;Prosencephalon;Protein Isoforms;Proteins;Research;Resources;Rhesus;Role;screening;Sequence Homology;sex;Signal Transduction;Skin;stem cells;Symptoms;Synapses;synaptic function;tau aggregation;tau mutation;tau Proteins;tau-1;Tauopathies;Temporal Lobe;Testing;therapeutic target;Transcript;transcriptome sequencing;transcriptomics;Translational Research;Up-Regulation;Vesicle;Wisconsin

PROJECT_TITLE: In vitro nonhuman primate model of frontotemporal dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


ADMINISTERING_IC: AI

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE Human cytomegalovirus (HCMV) is a ubiquitous human pathogen for which there remains no fully approved vaccine. We have identified a new host factor, stem-loop binding protein, required for infectivity of this virus. The proposed work will determine why this protein is important for HCMV infectivity and how it facilitates viral infection, with the ultimate goal of understanding the virus lifecycle fully to develop better therapeutic interventions.

PI_NAMEs: MORRISON, KYLEE MARIE (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: 3' Untranslated Regions;Affect;Binding;Binding Proteins;Biology;Candidate Disease Gene;candidate identification;Cell Nucleus;cell type;Cells;Chromatin;Cytomegalovirus;Cytomegalovirus Infections;Cytoplasm;Data;Defect;Disease;DNA;DNA biosynthesis;Doxycycline;experimental study;Fibroblasts;Gene Expression;Genetic Transcription;Genome;Goals;Growth;Histones;Human;human pathogen;Immune signaling;In Vitro;Infection;Integration Host Factors;knock-down;Lead;Life Cycle Stages;loss of function;Mass Spectrum Analysis;Measures;Mediating;Messenger RNA;mutant;novel;nuclease;particle;Plaque Assay;Poly(A) Tail;Process;Production;Productivity;Protein Deficiency;Proteins;Publishing;Reporting;Resistance;RNA;RNA Binding;Role;small hairpin RNA;stem;Testing;Therapeutic Intervention;transcriptome sequencing;Translating;Translations;Vaccines;Viral;Virion;Virus;Virus Diseases;Work

PROJECT_TITLE: Defining how SLBP promotes infectivity of HCMV

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Compulsive use despite adverse consequences is a hallmark of alcohol use disorder, a symptom that is commonly modeled preclinically through “aversion resistance”. Evidence suggests that neural inputs to the lateral habenula may play a role in aversion-resistant alcohol consumption, yet the underlying mechanisms of this phenomenon remain undefined. Here, we will examine excitatory and inhibitory inputs to the lateral habenula in a model of aversion-resistant drinking to elucidate a putative molecular basis for aversion dysregulation in alcohol use disorder.

PI_NAMEs: KERMOADE, KLAITEN E (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: addiction;Address;adverse outcome;Affect;alcohol availability;Alcohol consumption;alcohol misuse;alcohol use disorder;Alcohols;Animal Model;Animals;Aversive Stimulus;Behavior;behavior influence;Behavioral;Brain region;career;Cell Nucleus;Consumption;Development;Down-Regulation;drinking;drinking behavior;Elements;Ethanol;Exhibits;experimental study;Fiber;Foundations;gamma-Aminobutyric Acid;Globus Pallidus;Glutamates;Goals;Habenula;Histologic;Histological Techniques;Immunohistochemistry;improved;In Situ Hybridization;in vivo;insight;interest;Knowledge;Laboratories;Lateral;Measurement;Measures;Methods;Modeling;Molecular;neural;neural circuit;Neurobiology;neurochemistry;neuromechanism;Neurons;Neurosciences;neurotransmission;Neurotransmitters;Optics;optogenetics;Pattern;Pharmaceutical Preparations;Photometry;Physiological;Pre-Clinical Model;pre-clinical research;prevent;psychologic;Quinine;Rattus;real time monitoring;receptor;Recording of previous events;Research;Research Personnel;Resistance;response;Rewards;sensor;Signal Transduction;Site;substance use;Substance Use Disorder;Symptoms;Taste Perception;Techniques;Testing;Training;trait;Transferable Skills;Up-Regulation;Viral;Work

PROJECT_TITLE: Illuminating Neurobiological Adaptations of Afferent Projections to the Lateral Habenula During Aversion-Resistant Alcohol Consumption


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Human Genome;Hypertension;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Social determinants of health (SDOH) in childhood may contribute to increased blood pressure in young adults, leading to earlier development of hypertension and cardiovascular disease risk later in life that cannot be fully mitigated by optimal blood pressure reduction. Adverse early life SDOH have also been linked to epigenetic alterations in DNA methylation, therefore we hypothesize that early life SDOH are associated with young adult blood pressure, and that DNA methylation statistically mediates these associations. The proposed research, utilizing high-quality prospectively-collected longitudinal birth cohort data from >1400 participants and their parents in the Future of Families and Child Wellbeing study, will provide long-term insight into the complex interplay between SDOH factors, epigenetics, and blood pressure, adding to our understanding of primordial risk factor prevention in public health as well as tailored interventions to prevent hypertension.

PI_NAMEs: SZETO, MINDY  (contact)

PROGRAM_OFFICER_NAME: PURKISER, KEVIN

PROJECT_TERMS: Acceleration;Address;Adult;Age;age acceleration;aging related;analytical method;Anti-Hypertensive Agents;Award;biomedical informatics;Birth;Blood Pressure;blood pressure elevation;blood pressure reduction;built environment;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;career;Cause of Death;Child;Child Welfare;Childhood;Chronic Disease;Clinical;clinical development;cohort;Communities;Competence;Complex;Coronary Artery Risk Development in Young Adults Study;critical period;Data;Data Science;Development;Disease;Disparity;DNA Methylation;economic disparity;Economics;Education;Encapsulated;Environment;Epidemiology;epigenetic clock;Epigenetic Process;epigenome;epigenome-wide association studies;Ethnic Origin;Ethnic Population;Exposure to;Family;Fellowship;Future;Gene Expression;genome-wide;Genomics;Genotype;Goals;Health behavior;health care availability;high dimensionality;Hypertension;hypertension control;Immigrant;improved;Individual;informatics tool;insight;interest;Intervention;Investigation;Learning;Life;Life Cycle Stages;Linear Regressions;Link;Low income;Measures;Mediating;Mediation;Mediator;Mentorship;Methodology;Methods;Methylation;middle age;Modeling;modifiable risk;Modification;Molecular;Morbidity - disease rate;mortality;Myocardial Infarction;Nature;Neighborhoods;Normal Range;novel;Outcome;Parents;Participant;Pathway interactions;Pattern;personalized medicine;Persons;Phenotype;Physiological Processes;predictive tools;Prevalence;prevent;Prevention;prospective;Prospective, cohort study;Public Health;racial difference;racial diversity;racial population;Research;Research Personnel;Risk Factors;Sampling;Site;skills;social;social adversity;social determinants;social health determinants;socioeconomics;Stroke;Time;Training;United States;Unmarried;Work;Writing;young adult

PROJECT_TITLE: Social Determinants and Epigenetic Mediators of Hypertension in the Future of Families and Child Wellbeing Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

PHR: Overall Project Narrative: The proposed Center for Latino Health Research Opportunities (CLaRO) will conduct and promote community- engaged equitable implementation science career development to prepare Latino and non-Latino early-stage investigators (ESI) to conduct research on substance abuse, violence, HIV/AIDS, and mental health (SAVA+MH) in vulnerable Latino communities in the Miami-Dade County (MDC). CLaRO will contribute to the reduction and eventual elimination of Latino health disparities in MDC by training, mentoring, and supporting the next generation of health disparities scientists.

PI_NAMEs: DE LA ROSA, MARIO R;PRADO, GUILLERMO  (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Acceleration;Address;Affect;American;Applications Grants;Articulation;Attention;Award;career;career development;cohort;Collaborations;Communities;community collaboration;community engagement;County;Dedications;Development;Disparity;dissemination strategy;effectiveness research;Environment;Equity;Evidence based intervention;experience;farm worker;Florida;Funding;Goals;Grant;Health;Health Disparities Research;health disparity;health equity;health inequalities;Hispanic-serving Institution;HIV/AIDS;implementation efforts;implementation science;Individual;Infrastructure;inner city;innovation;Institution;International;Intervention;Knowledge;Latino;Latino Population;Lesbian Gay Bisexual Transgender Queer;Link;meetings;member;Mental Health;Mentors;Mentorship;Minority Groups;multidisciplinary;next generation;Pathway interactions;Pilot Projects;prevent;Privatization;Process;program dissemination;programs;Public Health;Research;research and development;research data dissemination;Research Personnel;Research Training;Resources;Role;Scientist;Seasons;Series;service providers;skills;Subgroup;Substance abuse problem;syndemic;Training;Translating;Underrepresented Minority;underserved community;United States National Institutes of Health;Universities;uptake;Violence;Work

PROJECT_TITLE: Center for Latino Health Research Opportunities-CLaRO

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 ML (J1)]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: PRADO, GUILLERMO  (contact)

PROJECT_TERMS: Address;Affect;American;Articulation;Automobile Driving;Award;career;career development;clinical translation;Collaborations;Communication;Communities;community engaged research;community engagement;Community Outreach;community partners;Consent;Consultations;County;Databases;Development;Ensure;Environment;Equity;Feedback;Florida;Fortification;Funding;Goals;Health;health disparity;health training;Hispanic-serving Institution;HIV;HIV/AIDS;implementation science;improved;Individual;Infrastructure;innovation;Institution;International;Latino;Latino Population;Lead;Libraries;Maintenance;Measures;meetings;member;Mental Health;National Institute of Mental Health;National Institute on Minority Health and Health Disparities;Participant;Pilot Projects;Positioning Attribute;Preparation;Privatization;Productivity;programs;recruit;Reduce health disparities;reduced substance abuse;Registries;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Role;Scientist;service providers;social media;Study Subject;Substance abuse problem;success;syndemic;Training Activity;Training and Infrastructure;training opportunity;Translational Research;Trauma;United States National Institutes of Health;Universities;Violence

PROJECT_TITLE: Center for Latino Health Research Opportunities-CLaRO - Administrative Core


NIH_SPENDING_CATS: Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BEHAR-ZUSMAN, VICTORIA  (contact)

PROJECT_TERMS: Academy;Acceleration;Address;Affect;Applications Grants;Award;Behavioral;career;career development;Characteristics;Collaborations;Communication;Communities;community collaboration;community engagement;Community Practice;Dedications;Development;Disparity;Eligibility Determination;Ensure;Equity;Evidence based intervention;experience;Faculty;Florida;Funding;Grant;Health;Health Disparities Research;health disparity;Healthcare Systems;HIV/AIDS;Home;implementation efforts;implementation intervention;implementation research;implementation science;Individual;Infrastructure;Institution;International;Intervention Studies;Latina;Latino;Latino Population;Lead;Link;Medicine;member;Mental disorders;Mental Health;Mentors;Mentorship;Minority Groups;minority health;minority health disparity;Mission;multidisciplinary;National Institute on Minority Health and Health Disparities;next generation;Participant;peer;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;Preparation;Process;programs;Recording of previous events;Records;Research;Research Infrastructure;Research Personnel;Resources;Scientist;Series;Speed;Substance abuse problem;success;Training;Training and Infrastructure;Translating;Underrepresented Minority;United States National Institutes of Health;Universities;Violence;virtual;Work

PROJECT_TITLE: Center for Latino Health Research Opportunities-CLaRO - Investigator Development Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

PI_NAMEs: ROJAS, PATRIA  (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Area;Caribbean region;Collaborations;college;Communities;community based participatory research;community engaged approach;community engaged research;community engagement;Community Health;Community Networks;community partners;Community Practice;Community Services;community setting;County;Development;Discipline of Nursing;dissemination strategy;Equity;Ethnic Origin;Evidence based intervention;experience;Faculty;Family;Florida;gender minority group;Goals;Health;health care availability;Health Disparities Research;health disparity;health inequalities;HIV;HIV/AIDS;Home;implementation intervention;implementation science;improved;innovation;International;Intervention;Knowledge;Latino;Latino Population;member;Mental Health;Mentors;metropolitan;mid-career faculty;multidisciplinary;next generation;Outcome;Pilot Projects;Positioning Attribute;Poverty;professor;programs;Public Health;Race;Reduce health disparities;Research;Research Assistant;Research Personnel;research to practice;Research Training;service providers;Sexual and Gender Minorities;Social Work;Subgroup;Substance abuse problem;substance use;syndemic;tool;Training;Translating;Translations;Trauma;Underserved Population;Universities;uptake;Violence;vulnerable community;Vulnerable Populations;Work

PROJECT_TITLE: Center for Latino Health Research Opportunities-CLaRO - Community Engagement & Dissemination Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SEATTLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE  Phosphofructokinase is a critical regulator of energy production during glycolysis. While activity of phosphofructokinase is tightly controlled to adapt to changing cellular energetic needs, the mechanisms underlying this tight control are not fully defined. Understanding the mechanisms of phosphofructokinase regulation is essential to advance our understanding of allosteric control of proteins, to define related disease pathologies, and to provide a foundation for the design of therapeutics and research tools.

PI_NAMEs: SALAY, LAUREN  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TITLE: Investigating the Structure and Regulation of PFK

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Immunotherapy;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE We will develop imaging and blood-based biomarkers to predict immunotherapy response and clinical benefit in lung cancer. Successful completion of the project will afford a noninvasive approach to accurate prediction of immunotherapy response. This may lead to personalized treatment strategies and improve outcomes for lung cancer patients.

PI_NAMEs: DIEHN, MAXIMILIAN ;LI, RUIJIANG  (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Address;Architecture;Biological Markers;Biology;Blood;Blood specimen;blood-based biomarker;cancer care;Cancer Etiology;cancer immunotherapy;Cancer Patient;Cells;Cessation of life;Characteristics;Clinical;clinical translation;cohort;Combined Modality Therapy;Data;Data Set;deep learning;deep learning model;design;Diagnosis;Evaluation;Evolution;experience;Financial Hardship;Habitats;Heterogeneity;Histology;Image;imaging biomarker;imaging modality;Immune;Immune checkpoint inhibitor;Immunologic Markers;Immunotherapy;improved;improved outcome;individual patient;individual response;innovation;Institution;Knowledge;Machine Learning;Malignant neoplasm of lung;Measurement;Medical Imaging;Methods;Modeling;Morphology;multimodal data;multitask;Mutation;non-invasive imaging;Non-Small-Cell Lung Carcinoma;novel;Oncogenes;Outcome;outcome prediction;patient population;Patients;Performance;performance tests;personalized biomarkers;personalized medicine;Phenotype;precision oncology;predicting response;Prediction of Response to Therapy;predictive marker;prognostic;programmed cell death ligand 1;prospective;Prospective cohort;Protocols documentation;Radiology Specialty;radiomics;response;Retrospective cohort;Sampling;serial imaging;standard care;standard of care;Statistical Models;success;survival outcome;Systemic disease;Techniques;Testing;Texture;Tissues;Toxic effect;Training;Treatment outcome;treatment strategy;tumor;tumor DNA;tumor heterogeneity;tumor microenvironment;Tumor-Associated Vasculature;United States;Validation;Variant;visual information;Work;X-Ray Computed Tomography

PROJECT_TITLE: Noninvasive imaging and blood biomarkers for personalized lung cancer immunotherapy

STUDY_SECTION: TIO

STUDY_SECTION_NAME: Translational Immuno-oncology Study Section[TIO]


ADMINISTERING_IC: IP

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Vaccination rates among adults are low, especially among vulnerable populations, such as pregnant women, infants, persons with chronic medical conditions, historically marginalized populations, and persons with low income. Increased efforts to vaccinate adults have not been successful. Opportunities for healthcare providers, a trusted source for vaccine information, to educated and immunize their patients are limited by (1) time, (2) possible lack of information on recommendations, efficacy and safety and (3) effective communication approaches. The goal of this project is to develop, evaluate and disseminate an evidence-based Adult Immunization Quality Improvement Program – Adult IQIP - that integrates adult-specific strategies across healthcare provider settings to increase coverage for adults as similar programs have for childhood immunization coverage. To accomplish Aim 1, systematic reviews of the published and grey literature will be conducted; 64 federally funded state, territorial, and local public health immunization programs (IPs) will be surveyed; and site visits will be conducted including Root Cause Analysis. This information will be synthesized to create an Adult IQIP program (Aim 2). To accomplish Aim 3, our Adult IQIP program will be implemented, supported and monitored in 20 adult immunization practices (FQHC/RHC, Free Clinics, Family Medicine) in Virginia and Washington state. Changes in adult immunization coverage, before and after implementation will be determined and compared to control practices. A decision-tree model will be employed to examine longer-term cost effectiveness from a societal, immunization program and practice perspective. Broad dissemination will be accomplished by the Association of Immunization Programs (AIM) and through our professional network of Advisory Committee stakeholders.

PI_NAMEs: SALMON, DANIEL A (contact)

PROJECT_TITLE: RFA-IP23-002 Adult Immunization Quality Improvement for Providers (IQIP)


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE This study will generate robust evidence for the impact of minimum wage increases on community violence victimization (including robberies, sexual assaults, and IPV victimization), assault injuries, and homicide deaths; will evaluate how minimum wage increases impacted community violence; will assess how the COVID- 19 pandemic affected community violence and is potentially moderated by economic impact payments; will examine the racial/ethnic, gender, age, and geographic disparities among these associations; and will evaluate the joint impact of the COVD-19 pandemic and minimum wage increases on community violence.

PI_NAMEs: RANAPURWALA, SHABBAR I (contact);SANTAULARIA, N. JEANIE

PROJECT_TITLE: RFA-CE-23-004: Structural factors Impacting community Violence (STRIVE): The Role of Minimum Wage, COVID-19, and Discrimination


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

PHR: Project Narrative The overall goals of the proposed Career Development Award (K01) are relevant to public health because it evaluates the relationship between community conditions and multiple forms of violence against children, an area with limited research but a strong scientific premise. Rigorous evidence regarding this relationship can be instrumental to better understanding violence against children and in the development of effective prevention strategies. Thus, the proposed project is relevant to the CDC Injury Center’s Research Priority of reducing and preventing the interpersonal violence that impacts children and youth.

PI_NAMEs: REBBE, REBECCA  (contact)

PROJECT_TITLE: CE23-003 - A multi-level examination of social safety net accessibility as a modifiable structural condition contributing to violence against children


ADMINISTERING_IC: OH

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative At the Fire Department of the City of New York (FDNY) World Trade Center Health Program (WTCHP), 36% of participants in our low dose computed tomography (LDCT) lung cancer screening program are current smokers, despite referral to the free FDNY Tobacco Cessation Program (Standard Care). We propose to test an Enhanced Care program which includes opt-out enrollment in our quit smoking program; tobacco cessation counseling individually tailored to LDCT results and treatment with varenicline starting 4 weeks prior to their target quit date. The proposed randomized trial will compare enrollment and cessation outcomes in Standard Care vs. Enhanced Care groups of challenging-to-treat, high-risk smokers.

PI_NAMEs: GOLDFARB, DAVID G (contact)

PROJECT_TITLE: Preventing Lung Cancer through Tobacco Cessation at FDNY


ORG_DEPT: CHEMISTRY

PHR: Project Narrative The focus of this application is on organic transformations facilitated by catalysts based on nickel, an inexpensive and abundant metal, which have the potential to provide new synthetic methods to construct bonds that are difficult or impossible to form using traditional methods. At this stage, the development of nickel catalysts is limited by our lack of fundamental understanding of their properties and through careful mechanistic studies this work will fill that void and apply the knowledge acquired to rationally design new systems for reactions such as cross-electrophile coupling. Overall, the project aligns with the NIH's mission to improve human health because it will develop more efficient methods for discovering and synthesizing pharmaceuticals.

PI_NAMEs: HAZARI, NILAY  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Catalysis;catalyst;Chemistry;Chlorides;Collaborations;Complex;Computational Technique;Coupling;design;Development;Esters;experimental study;Generations;Guidelines;Health;Human;improved;In Situ;Investigation;Kinetics;Knowledge acquisition;Libraries;Ligands;Metals;Methods;Mission;Mole the mammal;nano;next generation;Nickel;Nitrogen;novel;novel strategies;Pathway interactions;Pharmaceutical Chemistry;Pharmacologic Substance;Process;Property;rational design;Reaction;Reducing Agents;Salts;scale up;Series;System;Transition Elements;United States National Institutes of Health;Work

PROJECT_TITLE: Fundamental Studies of Ni-Catalyzed Organic Reactions


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Nanotechnology;Prevention

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: PUBLIC HEALTH RELEVANCE We propose to implement and test a structure-informed platform for developing novel designer camelid antibody multimers as next-generation antitoxin and antiviral products, likely delivered as RNA nanoparticles, which possess excellent potencies in treating poisoning or viral infections and are effective against a broad range of natural pathogen variants. Our research will focus on two pathogens that are major current threats for which a standard of care exists but would benefit from next-generation therapeutics, botulinum neurotoxin (BoNT) and SARS-CoV-2. If successful, this approach could become a paradigm platform for rapid and responsive future development of therapeutic or prophylactic products for a wide variety of microbial threats including bioterror threat agents and emerging viruses.

PI_NAMEs: JIN, RONGSHENG ;SHOEMAKER, CHARLES BIX (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Affinity;Animal Disease Models;Animal Model;Animals;anti-toxin;Anti-viral Agents;Antibodies;Antibody Therapy;Area;Autoimmune;Binding;Biological Assay;Bioterrorism;Botulinum Toxins;Botulism;Cell Culture Techniques;Characteristics;Clinical;clinically relevant;Clostridium difficile;Communicable Diseases;Complex;cost;COVID-19 pandemic;COVID-19 patient;Dangerousness;Data;design;Development;Disease;disorder prevention;emerging virus;Epitopes;Equus caballus;Evolution;Family;Funding;Future;Goals;High Prevalence;Human;human disease;Immune;Immune Sera;improved;in vivo;Infection;Intoxication;Intramuscular;Lead;Length;Life;Link;Malignant Neoplasms;manufacture;Mediating;Messenger RNA;microbial;Modeling;Monoclonal Antibodies;Mus;nanobodies;nanoparticle;neutralizing antibody;next generation;novel;novel therapeutics;pandemic potential;Passive Immunotherapy;pathogen;Pathology;Poisoning;porcine model;prevent;product development;Production;Property;prophylactic;Prophylactic treatment;Proteins;public health relevance;receptor binding;Research;risk minimization;RNA;Route;SARS coronavirus;SARS-CoV-2 variant;Serotyping;Specificity;standard of care;Structure;technology platform;Testing;Therapeutic;Therapeutic Agents;Therapeutic antibodies;therapeutic development;Therapeutic Effect;Therapeutic Monoclonal Antibodies;Toxin;transmission process;United States National Institutes of Health;Vaccinated;vaccine efficacy;Variant;variants of concern;Viral;virtual;Virus;Virus Diseases;Work

PROJECT_TITLE: A versatile structure-based therapeutic platform for development of VHH-based antitoxin and antiviral agents

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(82)]


ORG_DEPT: UROLOGY

PHR: NARRATIVE Prostate cancer is the most common cancer in men and a source of significant morbidity and mortality (>30,000 deaths annually). This project will combine our cutting-edge basic science discoveries with clinical (surgical, medical and radiation oncologists) expertise to exploit novel observations that will improve outcomes and quality of life for patients with this disease. Using state-of-the-art imaging, bioinformatics and novel pathology resources we will develop new and exploit new diagnostic approaches and treatments that will change the way prostate cancer is managed.

PI_NAMEs: JARRARD, DAVID F. (contact);MCNEEL, DOUGLAS G.

PROGRAM_OFFICER_NAME: SCROGGINS, BRADLEY TODD

PROJECT_TERMS: 3-Dimensional;abiraterone;Ablation;Address;Adjuvant Study;Advanced Malignant Neoplasm;advanced prostate cancer;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;anti-cancer research;Area;Basic Science;biochip;Bioinformatics;Biological;Biomedical Engineering;Biometry;Cancer Patient;cancer therapy;career;Castration;Cessation of life;Clinical;clinical care;Clinical Trials;Combined Vaccines;Data;deprivation;Development;diagnostic strategy;Disease;Disease Progression;docetaxel;Environment;Feasibility Studies;Generations;Goals;high risk;Human;Image;immune checkpoint blockade;Immune response;Immunology;immunomodulatory therapies;Immunotherapy;improved;improved outcome;Individual;inhibitor;Institution;Knowledge;Lesion;Link;Local Therapy;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Medical Oncologist;men;Metastatic Prostate Cancer;Modeling;Molds;molecular imaging;Morbidity - disease rate;mortality;multidisciplinary;Neoadjuvant Therapy;next generation;novel;novel diagnostics;novel strategies;Outcome;Pathology;patient response;Patient-Focused Outcomes;Patients;pharmacologic;Phase I Clinical Trials;phase I trial;Positron-Emission Tomography;potential biomarker;Preclinical Testing;programs;Prostate;prostate cancer risk;Prostatectomy;Quality of life;Radiation Oncologist;Radiology Specialty;receptor vaccine;Research;Research Personnel;Research Project Grants;Research Proposals;Research Support;Resistance;Resources;response;Scientist;Signal Transduction;Source;Specimen;success;Surgical Oncologist;Therapeutic;therapeutic target;therapy resistant;Time;Tissues;Translating;translational goal;Translational Research;Treatment outcome;treatment response;treatment strategy;tumor;tumor heterogeneity;tumor microenvironment;Universities;vaccine evaluation;Wisconsin

PROJECT_TITLE: University of Wisconsin Prostate SPORE


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE The ultimate goal of the Administrative Core is to provide the operational structure necessary to support the UW Prostate Cancer SPORE Executive Leadership, Project Leaders and Development and Core Directors for the successful conduct of this grant. This grant is directly relevant to the mission of the National Cancer Institute as it is aimed at developing new treatments, and improving existing treatments, for prostate cancer.

PI_NAMEs: JARRARD, DAVID F. (contact)

PROJECT_TERMS: Administrative Coordination;Bioinformatics;Biometry;Cancer Center;cancer clinical trial;Clinical;Clinical Research;cohort;Collaborations;Communication;Communication Tools;Communities;Complex;Data Analyses;Data Collection;data management;data quality;Databases;design;Development;Electronic Mail;Ensure;Evaluation;Event;Fostering;Foundations;Funding;Goals;Grant;Human;improved;Information Dissemination;Infrastructure;Institution;Leadership;Malignant neoplasm of prostate;medical schools;meetings;Mission;Monitor;National Cancer Institute;news;Office of Administrative Management;Oncology;Participant;patient population;Patients;Population;Process;Productivity;Program Development;programs;Prostate;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Services;Structure;Supervision;Translation Process;Translational Research;Universities;web site;Wisconsin

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Lymphatic Research;Prevention;Prostate Cancer;Urologic Diseases

PHR: Project Narrative There is a critical need to understand the initial biologic steps that lead to invasive and metastases in locally advanced prostate cancer, a disease state which accounts for >60% of men who die from the disease. We have developed complementary technologies to identify and analyze patient tumors using a new microphysiologic system of lympho-vascular invasion. These tools are deployed in two prospective patient cohorts to study underlying mechanisms of metastases, identify new biomarkers and develop new therapeutic strategies for this patient population.

PI_NAMEs: LANG, JOSHUA MICHAEL (contact)

PROJECT_TERMS: 3-Dimensional;abiraterone;Adjuvant Study;advanced prostate cancer;Androgen Receptor;arm;Biological;Biological Markers;Biological Models;biomarker development;biomarker identification;Cancer and Leukemia Group B;Cell Differentiation process;Cell Proliferation;cell type;Cells;Clinical Trials;cohort;Combined Modality Therapy;Complex;Data;Data Set;digital;Disease;Dissection;DNA Sequence Alteration;docetaxel;drug development;Early Diagnosis;Engineering;Evaluation;exome sequencing;Failure;Fibroblasts;FOLH1 gene;Genetic Transcription;Genomics;Goals;Heterogeneity;high risk;hormone therapy;Image;Immune;immune cell infiltrate;In complete remission;Incidence;inhibitor;Invaded;Lesion;Lymphatic;lymphatic Invasion;lymphatic vessel;Lymphovascular;Macrophage;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;men;Metabolism;Metastatic/Recurrent;microphysiology system;migration;Modeling;Molds;Molecular;Molecular Analysis;molecular phenotype;MRI Scans;Multifocal Lesion;Mutation;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;Newly Diagnosed;novel;novel therapeutic intervention;Operative Surgical Procedures;Outcome;Pathologic;patient population;Patients;Permeability;phase II trial;phase III trial;Phenotype;Population;Positron-Emission Tomography;potential biomarker;Pre-Clinical Model;prospective;Prostate;prostate cancer cell;prostate cancer metastasis;prostate cancer risk;Prostatectomy;Prostatic Neoplasms;PTEN gene;radiological imaging;Randomized;Receptor Signaling;Resistance;response;Sampling;Scanning;Slice;Specimen;Stromal Cells;success;Technology;technology platform;Testing;therapeutic target;therapy resistant;tool;TP53 gene;transcriptome sequencing;transcriptomics;tumor;Tumor Cell Invasion;tumor DNA;tumor growth;tumor microenvironment;Universities;Wisconsin;Work

PROJECT_TITLE: Project 1: Tumor Microenvironment Initiators of the Metastatic Cascade in High-Risk Prostate Cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Immunotherapy;Prevention;Prostate Cancer;Urologic Diseases;Vaccine Related

PHR: PROJECT NARRATIVE The ultimate goal of our research has been to develop effective anti-tumor vaccines as treatments for cancer, and prostate cancer in particular. We have studied the androgen receptor (AR) as a target for vaccination, and recently completed a phase I trial evaluating an AR-targeted vaccine. We have also recently identified that androgen deprivation, the cornerstone of therapy for men with recurrent prostate cancer, results in AR overexpression in prostate cancer cells, and this makes them more amenable to recognition by AR-specific CD8+ T cells. Combining these treatments results in a greater anti-tumor response in murine models. We have further found, in preclinical studies and clinical trials, that T-cell checkpoint blockade (notably targeting PD-1) with vaccination leads to greater anti-tumor effects. Together these findings form the basis for the current proposal using murine models and a pilot clinical trial to evaluate AR-targeted vaccination in combination with androgen deprivation and T-cell checkpoint blockade for their anti-tumor efficacy and establishment of immune memory. Thus, this application is directly relevant to the mission of the National Cancer Institute.

PI_NAMEs: MCNEEL, DOUGLAS G. (contact)

PROJECT_TERMS: advanced prostate cancer;Affect;androgen deprivation therapy;Androgen Receptor;Androgens;anti-tumor immune response;Antigen Targeting;Antigens;antitumor effect;Antitumor Response;arm;biomarker driven;cancer infiltrating T cells;cancer therapy;Cancer Vaccines;Castration;CD8-Positive T-Lymphocytes;Cell Line;Cells;checkpoint receptors;Clinical;clinical development;Clinical Trials;Combined Modality Therapy;deprivation;design;Development;Disease;Disease Resistance;DNA Vaccines;Epitope spreading;Epitopes;Evaluation;Goals;Health;high risk;HLA-A2 Antigen;Human;Immune;immune cell checkpoints;immune checkpoint;immune checkpoint blockade;immune function;Immune response;Immunization;Immunologic Memory;Immunologics;immunomodulatory therapies;Immunotherapy;improved;Infiltration;inhibitor;Interferon Type II;Laboratories;Ligand Binding Domain;Malignant neoplasm of prostate;Malignant Neoplasms;Memory;men;Metastatic Prostate Cancer;Methods;Mission;Modification;mouse model;Mus;Myeloid Cells;National Cancer Institute;Neoadjuvant Therapy;neoplastic cell;Newly Diagnosed;novel;Outcome;overexpression;Pathway interactions;Patients;Phase I Clinical Trials;phase I trial;Population;Pre-Clinical Model;preclinical study;Production;programmed cell death ligand 1;programmed cell death protein 1;Prostate;prostate cancer cell;prostate cancer model;prostate cancer risk;Prostate Cancer therapy;Prostatectomy;Prostatic Neoplasms;Proteins;receptor;receptor vaccine;recruit;Recurrence;Regulatory T-Lymphocyte;Research;Research Personnel;Resistance;resistance mechanism;response;T cell infiltration;T memory cell;T-Cell Activation;T-Cell Development;T-Lymphocyte;Testing;Therapeutic Effect;therapy development;Thymus Gland;Time;Tissues;Transgenic Mice;tumor;tumor DNA;tumor eradication;Universities;Vaccination;vaccination outcome;Vaccines;Wisconsin

PROJECT_TITLE: Project 2: Androgen deprivation as an immune modulating therapy in combination with targeted immunotherapy of prostate cancer


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Radiation Oncology;Urologic Diseases

PHR: PROJECT NARRATIVE The goal of this proposal is to leverage advantages of molecular imaging combined with advanced image analytics in order to identify individual patients with metastatic prostate cancer that may benefit from targeted ablation of individual resistant lesions in order to extend treatment benefit. The main outcome of our effort is optimization of the entire patient care continuum with existing treatment options.

PI_NAMEs: JERAJ, ROBERT  (contact)

PROJECT_TERMS: Ablation;Androgen Receptor;Androgens;Anxiety;Area;bone;Castration;chemotherapy;Clinical;Continuity of Patient Care;Data;Deterioration;Disease;Disease Progression;disorder control;Enrollment;experience;Feasibility Studies;fluorodeoxyglucose positron emission tomography;FOLH1 gene;Generations;Goals;Heterogeneity;Image;imaging study;improved;Individual;individual patient;inhibitor;innovation;Lesion;Location;Medical Imaging;men;Metastatic Prostate Cancer;Methodology;Modeling;molecular imaging;Neoplasm Metastasis;new technology;Outcome;Pathway interactions;Patient Care;Patients;personalized approach;PET/CT scan;Phase Ib Trial;Positron-Emission Tomography;Progression-Free Survivals;prospective;Prostate;Provider;quantitative imaging;Radiation;Radiation therapy;Radio;radioligand;radiological imaging;Resistance;response;safety and feasibility;Signal Transduction;Site;Spinal Cord;Systemic Therapy;Technology;Testing;Therapeutic Clinical Trial;therapy development;therapy resistant;Time;Tracer;treatment response;Tumor Burden;Universities;virtual;virtual clinical trial;Weight;Wisconsin;Work;X-Ray Computed Tomography

PROJECT_TITLE: Project 3: Extending Clinical Benefit by Selective Treatment of Resistant Lesions in mCRPC


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Urologic Diseases

PI_NAMEs: HUANG, WEI  (contact)

PROJECT_TERMS: 3-Dimensional;Address;androgen independent prostate cancer;anti-cancer research;Bioinformatics;Biological Markers;Body Fluids;Cancer Center;cancer imaging;Cancer Patient;Cancer Research Project;Clinical;Clinical Trials;clinically significant;Collaborations;Communities;Consultations;Correlation Studies;Data;Databases;Dedications;design;digital;FOLH1 gene;Formalin;Freezing;Future;Goals;Hematoxylin and Eosin Staining Method;Histologic;Histology;Histopathology;Image;image archival system;image translation;Immunofluorescence Immunologic;Immunohistochemistry;Infrastructure;Lesion;Link;Localized Lesion;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Mission;Molds;Neoplasm Circulating Cells;Neoplasm Metastasis;Organoids;Paraffin Embedding;Pathology;pathology imaging;patient derived xenograft model;Peripheral Blood Mononuclear Cell;Plasma;Positron-Emission Tomography;preservation;Process;Prostate;prostate cancer cell;Prostatectomy;quantitative imaging;Radiation therapy;radiological imaging;Radiology Specialty;repository;Reproducibility;Research Personnel;Resistance;Resources;Services;Stains;Technology;Tissue Embedding;Tissue Microarray;Tissues;Treatment outcome;treatment response;tumor;Tumor Pathology;Universities;whole slide imaging;Wisconsin

PROJECT_TITLE: Core 1: Integrated Pathology and Radiology Core (iPRC)


PI_NAMEs: ZHAO, SHUANG  (contact)

PROJECT_TERMS: archive data;Archives;Area;Basic Science;Bioinformatics;Biometry;Biostatistics Shared Resource;Cancer Center;career;career development;Clinical;Clinical Research;Clinical Sciences;Collaborations;Consultations;Data;Data Analyses;data archive;Data Collection;data management;data sharing;data standards;Dedications;design;Development;Doctor of Philosophy;Ensure;experience;Experimental Designs;experimental study;Formulation;Head and neck structure;Human;Human Resources;Individual;Information Dissemination;Laboratories;Laboratory Study;Malignant neoplasm of prostate;Manuscripts;Medical Informatics;Methods;multidisciplinary;Neck Cancer;neoplasm resource;Office of Administrative Management;Oncology;Pathology;Physicians;professor;Program Development;programs;Prostate;Publications;quality assurance;Quality Control;Radiology Specialty;Research;Research Design;Research Personnel;research study;Resource Sharing;Resources;Role;Scientist;Secure;Senior Scientist;Standardization;success;translational cancer research;Translations;Universities;Validation;Wisconsin;Writing

PROJECT_TITLE: Core 2: Biostatistics and Bioinformatics Core (BBC)


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Prostate Cancer;Urologic Diseases

PI_NAMEs: LIU, GLENN  (contact)

PROJECT_TERMS: Area;Basic Science;Budgets;Caliber;Cancer Biology;Cancer Center;career;Clinical;Clinical Trials;Collaborations;Communities;Development;Direct Costs;Disease Outcome;Early Diagnosis;Ensure;Faculty;Feedback;Funding;Future;Grant;Guidelines;high reward;high risk;improved outcome;innovation;insight;Institution;Investigator-Initiated Research;Laboratories;Malignant neoplasm of prostate;meetings;Minority Groups;Mission;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Patients;Peer Review;Phase;Population;predictive marker;Prevention;Process;Prognostic Marker;Program Research Project Grants;programs;Prostate;Publications;Recommendation;Research;Research Personnel;research study;Resources;Rewards;Schools;Stream;survivorship;Thinking;translational goal;Translational Research;Treatment outcome;Underrepresented Minority;United States National Institutes of Health;Universities;Update;Wisconsin;Work

PROJECT_TITLE: Developmental Research Program


PROJECT_TERMS: Achievement;anti-cancer research;Attitude;Award;bench to bedside;Biomedical Engineering;career;Clinical;Clinical and Translational Science Awards;Communities;Development;Discipline;Discipline of Nursing;Educational Curriculum;Environment;Evaluation;experience;Faculty;Fostering;Funding;Future;Goals;innovation;Institution;interest;Interview;Knowledge;Laboratory Research;Leadership;Malignant neoplasm of prostate;Marketing;McArdle Laboratory for Cancer Research;Medical;member;Mentors;Methods;next generation;Pharmacy facility;Physicians;Physics;prevent;Process;programs;Progress Reports;Prostate;prostate oncology;recruit;Research;Research Personnel;Resources;Schools;Scientist;skills;Solid;Structure;Time;Training;translational cancer research;Translational Research;translational scientist;undergraduate research;undergraduate student;United States National Institutes of Health;Universities;Wisconsin;Woman

PROJECT_TITLE: Career Enhancement Program


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: GAINESVILLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE A number of transformative advances have recently occurred at the intersection of type 1 diabetes (T1D) and biomedical engineering (BME), including the development of technology-based strategies for disease management as well as progress towards the first T1D immunotherapy, an effort currently under review by United States Food and Drug Administration (FDA). To address the rapidly growing need for individuals cross-trained in these arenas, we established this interdisciplinary graduate program to facilitate co-mentoring of pre-doctoral students in BME and T1D. Given our program’s 100% retention of graduates in science careers to date, alongside prioritization to those with underrepresented minority or disability designations, we are confident that the training environment supported by this T32 will continue to prepare the next generation of researchers for careers seeking to develop new strategies for the management, prevention and reversal of T1D.

PI_NAMEs: ATKINSON, MARK A. (contact);KESELOWSKY, BENJAMIN GEORGE

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Biomedical Engineering;Insulin-Dependent Diabetes Mellitus;programs

PROJECT_TITLE: Interdisciplinary Graduate Program in Type 1 Diabetes and Biomedical Engineering

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Digestive Diseases;Neurodegenerative;Neurosciences

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE Oropharyngeal dysphagia (OD), a devastating syndrome that affects nearly 90% of hospitalized patients with Alzheimer’s disease (AD) and AD-related dementias (AD/ADRD), is a significant predictor of care-partner burden. Indeed, upon hospital discharge, care partners of patients with AD/ADRD face dramatic and persistent OD-related unmet caregiving needs, which lead to higher care-partner burden. The Web-based Care Partner Tool for Feeding in Dysphagia (WeCareToFeedDysphagia) addresses OD-related caregiving needs, which will reduce care partner burden and improve outcomes for patients with AD/ADRD and their care partners.

PI_NAMEs: DIEFENBACH, MICHAEL A;MAKHNEVICH, ALEX  ;SINVANI, LIRON DANAY (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Address;Affect;age-related disease;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Behavioral;caregiving;Caring;Cellular Phone;community partners;Competence;Consent;coping;Data;Deglutition Disorders;Dementia;design;Diagnosis;Diet;Eating;effective intervention;efficacy evaluation;expectation;experience;Face;Feedback;feeding;Feeling;Female;Frustration;Gender;Genetic Transcription;Goals;Health;Home Page;hospital care;Hospitalization;Hospitals;human old age (65+);improved;improved outcome;Informal Social Control;Intervention;intervention effect;Interview;Knowledge;Lead;Link;Liquid substance;Malignant neoplasm of urinary bladder;Mediating;Mediator;Medical Care Team;Methods;multidisciplinary;Online Systems;Oropharyngeal Dysphagia;Outcome;Participant;Patient-Focused Outcomes;Patients;Persons;Phase;pilot test;primary outcome;Quality of life;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Resources;secondary outcome;Self Efficacy;Severities;skills;stress management;Structure;success;Syndrome;System;Technology;Testing;tool;treatment as usual;Treatment Efficacy;United States National Institutes of Health;usability;web-based tool;Writing

PROJECT_TITLE: Reducing Burden in Care Partners of Community-Dwelling Persons with Dementia and Oropharyngeal Dysphagia


NIH_SPENDING_CATS: Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: NARRATIVE Health disparities in our nation are acute and increasing the diversity of biomedical research scientists is one key strategy to address this crisis. With the current deluge of health-related data and a projected 34% growth in the job market for statisticians from 2019 to 2029 (Bureau of Labor Statistics), now is the time to diversify our workforce in the specialties of biostatistics and data science. Herein, we plan to expand the pool of students from underrepresented groups in these disciplines by developing, conducting, and evaluating a summer course that teaches skills in biostatistics and data science, LA’s Biostatistics and Data Science Summer Training program at the University of Southern California (LA’s BeST @USC), with a focus on current research challenges in the study of heart and lung disease.

PI_NAMEs: LEWINGER, JUAN PABLO ;SIEGMUND, KIMBERLY D (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Acute;Address;Alaska;Alaskan;American Indians;Artificial Intelligence;Automobile Driving;Bachelor's Degree;Big Data;Biomedical Research;Biometry;Black race;built environment;California;career;Chronic;Clinical;Clinical Trials;Collaborations;college;Computers;Computing Methodologies;Conscious;Data;Data Science;Data Scientist;Development;Diagnostic;Discipline;Diverse Workforce;Education;Educational Curriculum;Educational process of instructing;Educational Status;Educational workshop;Electronic Health Record;Employment;Enrollment;Epidemiologic Methods;Epidemiology;ethnic diversity;Faculty;faculty mentor;Family;Female;follow-up;Funding;Generations;Genetic;Genomics;Goals;graduate school preparation;graduate student;Growth;hands on research;Health;health data;health determinants;health disparity;Heart Diseases;Historically Black Colleges and Universities;holistic approach;Individual;interdisciplinary approach;Interdisciplinary Study;Interview;Japanese American;job market;Latino;Latinx;Leadership;Learning;lectures;Life;Location;Lung Diseases;Machine Learning;medical specialties;Mentors;Mentorship;mindfulness;Monitor;multidisciplinary;National Heart, Lung, and Blood Institute;National Institute of Environmental Health Sciences;novel;Oral;Play;Population;Population Heterogeneity;Positioning Attribute;postgraduate education;Prevention;Preventive Medicine;professional atmosphere;programs;prospective;recruit;Research;Research Design;Research Project Grants;Role;Schools;Scientist;sensor;skills;Statistical Methods;statistics;student mentoring;Students;success;summer research;System;Talents;Time;Training;Training Programs;unconscious bias;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;wearable device;Woman;working group;Writing

PROJECT_TITLE: LA’s Biostatistics and Data Science Training Program (LA’s BeST)


ED_INST_TYPE: OVERALL MEDICAL

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE - OVERALL HCMV remains a significant cause of morbidity and mortality after Solid Organ Transplantation (SOT) and Hematopoietic Stem Cell Transplantation (HSCT), and myelosuppression is a common clinical manifestation of HCMV infection in these patients. The goal of our program is to elucidate the molecular mechanisms of HCMV regulation of host signaling in the establishment and maintenance of viral latency and reactivation, and how these processes control myeloid cell differentiation.

PI_NAMEs: STREBLOW, DANIEL N (contact);YUROCHKO, ANDREW D

PROJECT_TERMS: Address;Apoptosis;Bioinformatics;Biological Assay;Biometry;Black Box;Bone Marrow;CD34 gene;Cell Differentiation process;Cells;chemokine;Clinical;Collaborations;Complex;cytokine;Cytomegalovirus;Cytomegalovirus Infections;Environment;Epidermal Growth Factor Receptor;Event;Exhibits;Funding;gene interaction;Goals;Growth Factor;Growth Factor Receptors;Guanosine Triphosphate Phosphohydrolases;Hematopoiesis;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Human;humanized mouse;insight;Knowledge;Life Cycle Stages;Ligand Binding;Ligands;Link;Macrophage;Maintenance;Mediator;MEKs;MicroRNAs;Molecular;monocyte;Morbidity - disease rate;mortality;mutant;Myeloid Cells;Myelopoiesis;Myelosuppression;novel virus;Organ Transplantation;Pathway interactions;Patients;permissiveness;Process;Production;Productivity;programs;Proteins;Proto-Oncogene Proteins c-akt;reactivation from latency;Receptor Signaling;Regulation;Research Design;Research Project Grants;response;rho GTP-Binding Proteins;Role;Services;Shapes;Signal Induction;Signal Pathway;Signal Transduction;Solid;STAT1 gene;stem cell homeostasis;stem cell proliferation;Stem cell transplant;stem cells;synergism;Testing;Time;Tissues;transcriptome;Transplant Recipients;Viral;Viral Proteins;Virus;Virus Diseases;virus host interaction;Virus Latency;Virus Replication;Work

PROJECT_TITLE: Human Cytomegalovirus dysregulation of host hematopoietic progenitor cell signaling pathways to modulate latency and reactivation


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: BROOKLYN COLLEGE

PHR: PROJECT NARRATIVE The work proposed is relevant to public health, since it will help advance the development of metal-based cancer chemotherapeutics for ovarian cancer with improved pharmacological and clinical profiles than drugs currently used. Thus, the findings are ultimately expected to be applicable to the health of human beings.

PI_NAMEs: CONTEL, MARIA  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Advanced Development;Affect;Aftercare;angiogenesis;anti-cancer;anti-PD1 antibodies;Antibody-drug conjugates;Antineoplastic Agents;Biological;Biological Availability;cancer cell;Cancer cell line;Carboplatin;carboxylate;Cell Cycle;Cell Death;cell growth;Cell Line;chemotherapy;Cisplatin;Clinic;Clinical;Coupling;cytotoxic;cytotoxicity;Diagnosis;Disease;DNA;docetaxel;Dose Limiting;drug development;Encapsulated;Epidermal Growth Factor Receptor;Epithelial ovarian cancer;Evaluation;expectation;FDA approved;Formulation;Genetic;Geometry;Glutathione S-Transferase;Gold;Gold Compounds;Grant;Health;Human;immunogenic cell death;Immunoliposome;improved;In Vitro;in vivo;innovation;insight;intravenous administration;Invaded;Investigation;KDR gene;Ligands;Lip structure;Liposomes;Maintenance Therapy;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Metals;Methods;migration;Modeling;Monoclonal Antibodies;Mus;neoplastic cell;Newly Diagnosed;Operative Surgical Procedures;Ovarian;oxaliplatin;Paclitaxel;Parents;Patients;Pharmaceutical Preparations;pharmacologic;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Positioning Attribute;Postmenopause;Property;Public Health;Recurrence;Research;Research Training;Resistance;Solubility;standard of care;Students;Survival Rate;System;targeted agent;targeted delivery;targeted treatment;Therapeutic;thioredoxin reductase;Time;Trastuzumab;tumor;Tumor Debulking;United States;vector;Woman;Women's mortality;Work

PROJECT_TITLE: Platinum-Gold Compounds as Potential Chemo- and Targeted Agents for Ovarian Cancer


ORG_CITY: TUCSON

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Non-melanoma skin cancer, including cutaneous squamous cell carcinoma (cSCC), is the most common cancer. This proposal uses a novel physiologic cSCC murine model to address the critical need to understand the role of CD8 and CD4 T cells, especially the role of neoantigen-specific T cells, in controlling cSCC growth. Completion of this proposal will determine the features of neoantigen-specific T cell responses that constrain cSCC growth and identify features of cancer vaccination strategies that improve outcomes in cSCC and enhance response to anti-PD-1.

PI_NAMEs: ADAMS, ANNGELA CHRISTINA (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Address;Adoptive Transfer;Affinity;anti-PD-1;anti-PD1 therapy;Antibodies;antigen-specific T cells;Binding;Bioinformatics;Cancer Patient;cancer type;cancer vaccination;CD4 Positive T Lymphocytes;CD8B1 gene;Cells;Characteristics;comparative efficacy;Complex;cytotoxic CD8 T cells;Data;Dendritic Cells;Dermatologist;Development;Diagnosis;exome sequencing;Flow Cytometry;Foundations;Generations;Goals;Growth;Immune;Immune checkpoint inhibitor;Immunocompetent;immunogenic;immunogenicity;Immunologics;Immunotherapeutic agent;improved;improved outcome;in vitro testing;in vivo;Inbred BALB C Mice;Injections;innovation;Irradiated tumor;Laboratories;Light;Malignant Neoplasms;Mature T-Lymphocyte;Mediating;Melanoma;Melanoma patient;MHC antigen;MHC Class I Genes;MHC Class II Genes;Modeling;mouse model;Mus;Mutation;neoantigen vaccine;neoantigens;Neoplasm Metastasis;neoplastic cell;novel;novel drug class;Nude Mice;Outcome;Pathway interactions;Patients;Persons;Physiological;prevent;programmed cell death protein 1;receptor;Research;response;Role;Skin Cancer;Skin Carcinoma;skin squamous cell carcinoma;Stains;success;T cell response;T-Lymphocyte;Techniques;transcriptome sequencing;transplant model;Transplantation;treatment response;tumor;tumor growth;Vaccinated;Vaccination;vaccination strategy;vaccine strategy;Wild Type Mouse

PROJECT_TITLE: Neoantigen-specific T cells in a novel cutaneous squamous cell carcinoma model


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: NELSON, JAY A (contact)

PROJECT_TERMS: Adjuvant;Binding;biodefense;cell growth regulation;Collaborations;collaborative environment;Communication;Complex;Contracts;Cytomegalovirus;data dissemination;data sharing;Decision Making;Doctor of Philosophy;Emerging Communicable Diseases;Ensure;Environment;experience;Fostering;Goals;Grant;Hematopoietic stem cells;Human;Institution;International;Maintenance;meetings;member;Molecular;Monitor;National Institute of Allergy and Infectious Disease;Office of Administrative Management;Pacific Northwest;Pathogenesis;Principal Investigator;programs;reactivation from latency;Reporting;Research;Resources;Signal Pathway;Signal Transduction;United States National Institutes of Health;Viral;Virus Latency

PROJECT_TITLE: The Administrative Core


NIH_SPENDING_CATS: Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

PI_NAMEs: CAPOSIO, PATRIZIA  (contact)

PROJECT_TERMS: AMD3100;Animal Model;CD34 gene;cell type;Cells;Chemicals;Clinical;Collaborations;CSF3 gene;Cytomegalovirus;design;Engraftment;Exhibits;experimental study;Fetal Liver;Fetal Tissue Research;gene therapy;Generations;Genes;Goals;Growth;Health;Hematopoietic Stem Cell Mobilization;Hematopoietic stem cells;Human;Human Biology;human fetus tissue;human tissue;humanized mouse;immunodeficiency;In Vitro;in vivo;Infection;Infrastructure;inhibitor;Investigation;Knowledge;Latent virus infection phase;Macrophage;Modeling;Molecular;mouse model;Mus;mutant;Oregon;programs;Protein Isoforms;Publishing;reactivation from latency;Reporting;Research;Research Project Grants;Role;Science;Signal Pathway;Signal Transduction;small hairpin RNA;Source;Standardization;stem cell engraftment;Stem Cell Mobilization;stem cells;Supervision;Supporting Cell;System;Testing;Tissues;Umbilical Cord Blood;Universities;Vaccine Therapy;Viral;Virus;Virus Latency;Virus Replication;Work

PROJECT_TITLE: Humanized Mouse Core


PI_NAMEs: MCWEENEY, SHANNON K. (contact)

PROJECT_TERMS: Bioinformatics;Biological;Biology;Biometry;candidate validation;catalyst;Collaborations;Complex;Computing Methodologies;cost effective;Cytomegalovirus;Data;data management;data standards;Development;Ensure;Event;experimental study;FAIR principles;Generations;Genomics;Goals;Hematopoietic stem cells;Human;Infrastructure;insight;Intervention;Knowledge Extraction;Life Cycle Stages;mathematical model;method development;Methodology;Methods;MicroRNAs;Modeling;Molecular;Molecular Profiling;multiple omics;novel;outreach;Pathology;Pathway interactions;Phase;phenotypic data;Play;predictive modeling;programs;Protocols documentation;reactivation from latency;Regulation;Reproducibility;Research Design;Research Project Grants;Role;Secure;Security;Signal Pathway;Signal Transduction;Standardization;System;Technology;Technology Assessment;Viral;Virus;virus virus interaction;Visualization;Visualization software;Work

PROJECT_TITLE: Biostatistics and Bioinformatics Core


PI_NAMEs: GOODRUM, FELICIA D (contact)

PROJECT_TERMS: Address;Amino Acids;attenuation;CD34 gene;Cells;cofactor;Collaborations;collaborative approach;Complex;Cytomegalovirus;Cytomegalovirus Infections;Data;Defective Viruses;Dependence;Diagnostic;DNA Damage;Epidermal Growth Factor Receptor;Event;Genome;Goals;Growth;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Human;humanized mouse;In Vitro;in vitro Model;in vivo Model;Individual;Infection;insight;Integration Host Factors;Interferons;knock-down;Ligands;Maintenance;Maps;MEKs;MicroRNAs;Molecular;Morbidity - disease rate;mortality;mouse model;mutant;novel;novel virus;Organ;Outcome;Pathway interactions;PI3K/AKT;Play;Positioning Attribute;programs;Proteins;Proto-Oncogene Proteins c-akt;reactivation from latency;Receptor Signaling;recombinant virus;Regulation;Reporting;response;Role;scaffold;Signal Pathway;Signal Transduction;Solid;STAT1 gene;Switching Complex;synergism;Therapeutic;trafficking;transcription factor;ubiquitin-specific protease;Undifferentiated;Viral;Viral Proteins;Virus;Virus Activation;virus host interaction;Virus Latency;Virus Replication

PROJECT_TITLE: HCMV UL133/8 regulation of host cell signaling in viral latency and reactivation


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Human Genome;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Angiotensin inhibitors are guideline-recommended first-line treatment for all heart failure patients with reduced ejection fraction (HFrEF). Although these drugs contribute to the advancements in HFrEF patient outcomes over the last three decades, disparities in the response and effectiveness of these drugs halt the progression of heart failure hospitalization benefit and survival improvements. This research is relevant to the mission of the NIH because it innovatively incorporates pharmacogenomic and health services research to address the significant racial disparities in HFrEF hospitalizations of Black and White patients taking angiotensin inhibitors, therefore building upon previous research to help improve health outcomes of current and future HFrEF patients.

PI_NAMEs: LITTLETON, SHANA DENISE (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Address;Affect;African;American;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Angiotensins;Black Populations;Black race;career;Censuses;Clinical;Clinical Data;cohort;Complex;Computerized Medical Record;cost;Cox Proportional Hazards Models;Data;Data Set;dimension reduction;Disparity;Education;Effectiveness;EFRAC;experience;Fellowship;follow-up;Frequencies;Future;genetic variant;genomic data;Genomics;Goals;Guidelines;Health;health care availability;health care disparity;Health Insurance;Health Services Accessibility;Health Services Research;Health system;Heart failure;heart failure with reduced ejection fraction;Heritability;Hospitalization;hospitalization rates;improved;Individual;inhibitor;innovation;insurance claims;Knowledge;Learning;Methods;Michigan;Mission;Neprilysin;Outcome;Outcomes Research;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacogenomics;post-doctoral training;pre-doctoral;prevent;primary outcome;prospective;Race;racial disparity;Recommendation;Registries;Reporting;Research;Research Personnel;Resources;response;Risk;Role;skills;social;social factors;social health determinants;Social Interaction;Social support;Social Work;Socioeconomic Status;Surveys;System;Testing;Time;Training;Treatment outcome;United States National Institutes of Health;Universities;Validation;whole genome

PROJECT_TITLE: Addressing the Racial Disparity of Angiotensin Inhibitor Benefit in HFrEF Hospitalizations: Distinguishing Genomic and Social Factors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-D(20)L]


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

PROJECT_TERMS: Address;Apoptosis;Attenuated;CD34 gene;CDC42 gene;Cells;Chemicals;collaborative approach;Complex;Complication;Cytokinesis;Cytomegalovirus;defined contribution;Epidermal Growth Factor Receptor;Event;experimental study;G-Protein-Coupled Receptors;Goals;Guanosine Triphosphate Phosphohydrolases;Hematopoietic stem cells;Human;Immunosuppression;Infection;insight;Label;latent infection;Life;Ligand Binding;Ligands;Mediating;MEKs;MicroRNAs;migration;mutant;Mutation;Outcome;Pathway interactions;Play;Process;Proliferating;Proteins;reactivation from latency;Regulation;rho;rho GTP-Binding Proteins;Risk;Role;Shapes;Signal Pathway;Signal Transduction;stem cell homeostasis;Time;Transplant Recipients;Untranslated RNA;Viral;Viral Proteins;Virus;Virus Latency

PROJECT_TITLE: HCMV miRNA regulation of host cell signaling in viral latency and reactivation


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Social Determinants of Health

PHR: Project Narrative The purpose of this work is to understand if and how the quality of data collected during health care, especially from vulnerable patients and patients with less access to health care, may differ from one patient to another. We believe that these differences in data quality may make common and important medical predictions – like those about future heart health – less accurate and reliable for some patients. We will develop and test methods to identify these data quality differences and make medical predictions equally accurate for all patients.

PI_NAMEs: WEISKOPF, NICOLE GRAY (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Algorithm Design;Algorithms;Assessment tool;Automobile Driving;black patient;Cardiac health;Caring;Characteristics;Clinical;clinical decision-making;clinical predictors;clinical risk;community based practice;COVID-19 pandemic;Data;data quality;Data Reporting;Data Set;demographics;Development;Disparity;Documentation;Electronic Health Record;Ensure;Equitable healthcare;Equity;ethnic bias;Ethnic Origin;Failure;Future;Goals;Health;health care availability;Health Care Costs;health care delivery;health care disparity;health care service utilization;health difference;health equity;health inequalities;Health system;Healthcare;Healthcare Activity;Healthcare Systems;improved;Individual;Inequity;Ingestion;Intervention;Lead;Learning;Measures;Mediator;Medical;Methodology;Methods;Modeling;novel;Outcome;Patient Care;patient health information;patient population;Patient risk;Patient-Focused Outcomes;Patients;Pattern;perceived discrimination;Performance;point of care;predict clinical outcome;prediction algorithm;predictive tools;Provider;Race;racial bias;Research;Resources;Risk;Risk Assessment;Risk Estimate;risk prediction;risk prediction model;Security;Severity of illness;social determinants;social health determinants;Structural Models;Techniques;Testing;Time;tool;United States;Work

PROJECT_TITLE: Health equity and the impacts of EHR data bias associated with social determinants