ORG_STATE: MI

PI_NAMEs: SUN, DUXIN  (contact)

PROJECT_TERMS: absorption;anti-cancer therapeutic;Antineoplastic Agents;Binding Proteins;Biological Assay;Biological Markers;Blood;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;cancer heterogeneity;Chemical Structure;Clinical;Clinical Research;clinical translation;Clinical Trials Design;Collaborations;cost;Cytochrome P450;design;Developmental Therapeutics Program;dosage;Dose;drug development;drug discovery;Drug Kinetics;Drug Stability;Excretory function;Funding;Glossary;Goals;Grant;Hematopoiesis;Hepatocyte;image visualization;Immunology;In Vitro;in vivo;instrument;intravenous administration;Investigation;Joints;Knowledge;Label;Lead;Legal patent;liquid chromatography mass spectrometry;Malignant Neoplasms;mass spectrometric imaging;Mass Spectrum Analysis;member;Metabolism;Michigan;Microsomes;models and simulation;Names;novel;Oral Administration;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetic model;Phase;Phase I/II Clinical Trial;Phenotype;Plasma;Play;Population;Population Sciences;pre-clinical;programs;Property;Publications;Reaction;Regimen;Research;Research Personnel;Resolution;Resource Sharing;Resources;response;Role;Sampling;Scientific Advances and Accomplishments;Signal Transduction;small molecule;Spottings;Techniques;Tissues;tool;Toxic effect;Translational Research;tumor microenvironment;Universities

PROJECT_TITLE: Pharmacokinetics (PK)


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Boulder

ORG_COUNTRY: UNITED STATES

ORG_DEPT: CHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: NARRATIVE The goal of this training program is to prepare exceptional, rigorous and collaborative PhD graduates for productive, science-related careers in Biophysics or other fields. Well-trained biophysicists play essential roles in elucidating the molecular basis of human health and disease. Such researchers investigate the structures, mechanisms, and functions of crucial cellular components, thereby providing the information needed to (i) understand disease on a molecular level and (ii) design new treatments targeting diseases including cancer, diabetes, inflammation, heart disease, immune and neurological disorders.

PI_NAMEs: FALKE, JOSEPH J (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TITLE: Interdisciplinary Predoctoral Training in Molecular Biophysics

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PI_NAMEs: ROSS, BRIAN D. (contact)

PROJECT_TERMS: 3-Dimensional;Anatomy;Animals;Applications Grants;Basic Science;Biological;Biological Process;Bioluminescence;burden of illness;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;cancer initiation;Cell Physiology;Cells;Clinical Research;clinical translation;companion diagnostics;Computed Tomography Scanners;Computer Analysis;Data;data acquisition;Developmental Therapeutics Program;diagnostic biomarker;digital imaging;Fluorescence;Funding;Glossary;Growth and Development function;Hematopoiesis;Human;Image;Image Analysis;Immunology;in vivo imaging system;innovation;insight;instrumentation;Magnetic Resonance;Malignant Neoplasms;member;Methodology;Michigan;Molecular;molecular imaging;mouse model;Names;Population Sciences;Positron-Emission Tomography;pre-clinical;preclinical imaging;predictive marker;Preparation;programs;Protocols documentation;Publications;Research;Research Design;Research Personnel;Resistance;Resource Sharing;Resources;Sampling;Signal Transduction;Specimen;Therapeutic;Tissues;Translational Research;translational study;treatment response;tumor;tumor initiation;tumor microenvironment;Universities;Validation;Visualization

PROJECT_TITLE: Preclinical Molecular Imaging (PMI)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative The development of alternatives therapies for myocardial infarction is a major unmet clinical need. This proposal seeks to develop a new minimally invasive, biomaterial-based therapy for treating acute myocardial infarction.

PI_NAMEs: CHRISTMAN, KAREN L (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: Acute myocardial infarction;aged;Aging;Alternative Therapies;Animals;Apoptosis;Arrhythmia;Balloon Angioplasty;Binding;Biocompatible Materials;Cardiac;Cardiac Myocytes;cardiac repair;Catheters;Cause of Death;Cell Survival;Cell Therapy;Cells;Chronic;Clinical;cost;cytokine;Development;Echocardiography;Eligibility Determination;Endothelial Cells;Endothelium;Extracellular Matrix;Family suidae;Fibrosis;Functional disorder;Geometry;Germ Cells;Goals;healing;Heart;Heart failure;heart function;Histologic;Histology;Holter Electrocardiography;Hydrogels;Immune;immune cell infiltrate;Immunohistochemistry;immunoregulation;improved;Infiltration;Infusion procedures;Injectable;Injections;Intervention;Intravenous;Knowledge;Lead;Left;Left Ventricular Function;Liquid substance;Magnetic Resonance Imaging;Mediating;Meta-Analysis;Metabolism;minimally invasive;Modeling;Myocardial;Myocardial Infarction;Myocardium;neovascularization;novel therapeutics;Patients;Phase I Clinical Trials;Phenotype;polarized cell;Porosity;Pre-Clinical Model;Rattus;receptor;regeneration potential;Regenerative Medicine;repaired;Reperfusion Therapy;response;Rest;Route;Safety;scaffold;sex;single-cell RNA sequencing;Technology;Temperature;Therapy trial;Tissue Engineering;Tissues;transcriptomics;translational study;Treatment Efficacy;Vascular Permeabilities;Ventricular;Western World;Work

PROJECT_TITLE: Infusible Extracellular Matrix for Treating Myocardial Infarction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Precision Medicine

PI_NAMEs: SMITH, JANET L. (contact)

PROJECT_TERMS: Academia;Antineoplastic Agents;assay development;Basic Science;Binding;Biological;Biological Assay;Biophysics;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;Cancer Patient;Cell Culture System;Cell Physiology;Cellular Morphology;Chemicals;Clinical Research;Cloning;Collaborations;Consultations;Development;Developmental Therapeutics Program;Drug Design;drug development;drug discovery;drug related cancer;Drug Screening;Drug Targeting;Elements;Ensure;Equipment;Glossary;Goals;Hematopoiesis;high throughput screening;Image;Immunology;Industry;Institution;lead optimization;Libraries;Malignant Neoplasms;Measures;Medicine;member;Metabolic;Michigan;miniaturize;Molecular Target;mutant;Names;novel;Pathway interactions;Pharmaceutical Chemistry;Phenotype;Population Sciences;precision medicine;precision oncology;Process;programs;Proteins;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;response;RNA;screening;Services;Signal Transduction;structural biology;Structure;Therapeutic;three dimensional cell culture;tool;Training;translational pipeline;Translational Research;tumor microenvironment;Universities;Variant;Vendor;Work;X-Ray Crystallography

PROJECT_TITLE: Structural and Drug Screening (SDS)


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Orphan Drug;Rare Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PUBLIC HEALTH RELEVANCE This proposal is relevant to the public health because it will introduce novel, nonperturbative, nondestructive, elasticity-based metrics and finite element modeling to the evaluation of corneal cross-linking procedures, which are the current first line treatment for corneal ectatic disorders such as keratoconus. This approach will allow for the first in vivo analysis of the cross-linking procedure and facilitate new protocol development to individualize treatment parameters resulting in improved efficacy and safety and provide the first step necessary towards visual improvement for patients with keratoconus.

PI_NAMEs: DUPPS, WILLIAM JOSEPH;RANDLEMAN, JAMES BRADLEY (contact);SCARCELLI, GIULIANO

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3-Dimensional;Ablation;Acceleration;Accounting;Address;Affect;Animals;Behavior;Biomechanics;Clinic;Clinical;Clinical Research;clinical translation;cohort;Cornea;Corneal Stroma;crosslink;Data;Development;Diffusion;Disease;efficacy evaluation;Elasticity;Elements;Epithelium;Evaluation;Evolution;Excision;experimental study;Eye;FDA approved;Future;Goals;Human;human subject;Hydration status;Image;improved;In Situ;in vivo;in vivo evaluation;individualized medicine;Keratoconus;Keratoplasty;Lasers;Link;Longitudinal Studies;Maps;Measurement;Measures;Mechanical Stress;Mechanics;Methods;Microscopy;Modeling;Modulus;Morphology;novel;Optics;Oryctolagus cuniculus;Outcome;patient tolerability;Patients;Photorefractive Keratectomy;Photosensitizing Agents;predict clinical outcome;predictive modeling;Procedures;Process;programs;protocol development;Protocols documentation;Public Health;public health relevance;Quality of life;rational design;Recovery;Research;research clinical testing;Resistance;Resolution;response;Riboflavin;Safety;Shapes;Spatial Distribution;Speed;Techniques;Technology;Testing;Thick;Time;time use;Tissues;tomography;Translating;treatment planning;Treatment Protocols;Ultraviolet A radiation;Vision;Visual;Visual Acuity;Work

PROJECT_TITLE: Determining the Efficacy of Corneal Cross-Linking Protocols using Brillouin Microscopy


NIH_SPENDING_CATS: Biotechnology;Cancer;Prevention

PI_NAMEs: GIORDANO, THOMAS JAMES (contact)

PROJECT_TERMS: anti-cancer research;Basic Cancer Research;Biological Assay;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;Clinical Research;Consultations;Data;Developmental Therapeutics Program;Disease;Early Diagnosis;Ensure;Ethics;Evaluation;Excision;Fluorescence;Freezing;Fresh Tissue;Glossary;Hematopoiesis;Histology;Human;human tissue;Immunohistochemistry;Immunology;improved;Individual;Informed Consent;Institution;instrumentation;Investigation;Laboratory Research;liquid crystal polymer;Malignant Neoplasms;member;Michigan;Molecular;molecular pathology;Names;Neoplasm Metastasis;Normal tissue morphology;Operative Surgical Procedures;Paraffin;Paraffin Tissue;Pathologic;Pathology;Population Sciences;Prevention;Primary Neoplasm;Production;programs;Publications;repository;Research;Research Personnel;Resource Sharing;Safety;Sampling;Services;Signal Transduction;Slide;Specimen;Tissue Microarray;Tissue Procurements;Tissue Sample;Tissues;translational cancer research;Translational Research;tumor;Tumor Bank;tumor microenvironment;Tumor Tissue;Universities;whole slide imaging

PROJECT_TITLE: Tissue and Molecular Pathology (TMP)


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative  Chlamydia is a major cause of sexually transmitted infections in the U.S., and more cases of chlamydial genital infections are reported to the CDC than any other infectious disease. This project will investigate two new effects of Chlamydia on a differentiated host cell: primary cilia loss and cell cycle re-entry. The project will study the mechanisms by which Chlamydia infection induces these effects on its host cell and will test if these two host-pathogen interactions are functionally linked. Interventions to prevent Chlamydia-induced primary cilia loss and cell cycle re-entry may lead to a novel therapeutic strategy against Chlamydia infections.

PI_NAMEs: SUETTERLIN, CHRISTINE  (contact);TAN, MING

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Antibodies;aurora kinase A;Bacteria;Biology;Cell Culture Techniques;Cell Cycle;Cell Cycle Progression;Cell Differentiation process;Cell Line;Cell Surface Extensions;Cells;Centrosome;Chlamydia;Chlamydia Infections;Chlamydia trachomatis;Cilia;Communicable Diseases;Country;Data;Development;Disease Notification;Environment;Epithelial Cells;Flow Cytometry;G1/S Transition;genital infection;Goals;Growth;HDAC6 gene;human pathogen;Infection;inhibitor;Intervention;Knowledge;Learning;Link;Malignant Neoplasms;Measures;metaplastic cell transformation;Methods;Microbe;Microscopy;Modeling;Molecular;novel;novel therapeutic intervention;Organelles;pathogen;Pathway interactions;Phenotype;Physicians;Physiological;prevent;Proliferating;Reader;Regulatory Pathway;Reporter;Reporting;reproductive tract;Research Personnel;response;S phase;Scientist;Sexually Transmitted Diseases;Signal Transduction;Small Interfering RNA;Surface;Testing;Time;Virus

PROJECT_TITLE: Primary cilia loss and cell cycle re-entry in Chlamydia-infected cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-V(02)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PI_NAMEs: SAUNDERS, THOMAS LEE (contact)

PROJECT_TERMS: Animal Model;Animals;Bacterial Artificial Chromosomes;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;Cell Culture Techniques;Clinical Research;Complement;cost;cost effective;CRISPR/Cas technology;Developmental Therapeutics Program;Educational Status;Embryo;embryonic stem cell;Equipment;ES Cell Line;Faculty;Funding;gene function;Gene Modified;Gene Targeting;Gene Transfer Techniques;Genes;Genetic;Genetic Engineering;Genetically Engineered Mouse;Genome;genome editing;Genome engineering;Genotype;Glossary;Hematopoiesis;Immunology;Individual;Institution;interest;Intervention;Investments;Knock-in;knockout gene;Laboratories;LoxP-flanked allele;Malignant Neoplasms;medical schools;member;Michigan;Microinjections;Micromanipulation;Modeling;Mouse Embryonic Stem Cells;mouse model;Mus;Mutation;Names;Nature;Pathogenesis;Population Sciences;Production;programs;Rattus;Reagent;Reporter;Research;Research Personnel;Resource Sharing;Resources;Signal Transduction;stem cell genes;stem cell technology;Students;Technology;Testing;tool;Training;Transgenes;Transgenic Animals;Transgenic Organisms;Translational Research;tumor microenvironment;Universities;Validation;Work

PROJECT_TITLE: Transgenic Animal Models (TAM)


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Digestive Diseases;Genetics;Human Genome;Liver Cancer;Liver Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Rare Diseases

ORG_CITY: Ota

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: COVENANT UNIVERSITY

PHR: Project Narrative Aflatoxin B1 (AFB1) is a liver carcinogen that is a common contaminant of foods in sub- Saharan Africa where exposure starts very early in life during pregnancy. This study aims to find out if early life AFB1 exposure is associated with altered regulation of tumor suppressor genes in Nigerian newborns. The findings of this research could provide an understanding of how early- in-life AFB1 exposure increases the risk of early-onset liver cancer.

PI_NAMEs: ROTIMI, OLUWAKEMI ANUOLUWAPO (contact)

PROGRAM_OFFICER_NAME: POVLICH, LAURA

PROJECT_TERMS: adduct;Adolescence;Aflatoxin B1;Aflatoxins;Africa;Africa South of the Sahara;African;Animal Feed;Area;Aspergillus;Binding;Biological Products;Birth;bisulfite;Blood;Blood specimen;Breast Feeding;Cancer Etiology;carcinogenesis;Carcinogens;Cessation of life;Chemical Agents;Child;cohort;Country;Cytochrome P450;Data;Development;Diagnosis;Disease;Disease susceptibility;DNA;DNA Methylation;early childhood;early experience;early life exposure;early onset;Environment;Environmental Exposure;Environmental Pollutants;Enzymes;epigenetic marker;Epigenetic Process;epigenome;Exposure to;First Pregnancy Trimester;Food;Food Contamination;Gene Expression;Gene Expression Profiling;Goals;Grain;Hepatotoxicity;Heritability;High Pressure Liquid Chromatography;Hospitals;Human;in utero;Incidence;infancy;insight;Life;Link;Liver;liver development;Lysine;Malignant neoplasm of liver;Malignant Neoplasms;Methylation;Modification;Molds;Molecular;Mothers;Mutation;Newborn Infant;Nigeria;Nigerian;Nucleic Acids;Nutrient;Onset of illness;Organ;placental membrane;Plasma;Play;Poison;Polymerase Chain Reaction;Population;Predisposition;Pregnancy;Pregnant Women;prenatal exposure;Primary carcinoma of the liver cells;Process;Public Health;pyrosequencing;recruit;Regulation;Research;Research Personnel;Risk;RNA;Rodent;Role;Route;Rural;Testing;Third Pregnancy Trimester;Time;Toxic Environmental Substances;Tumor Suppressor Genes;Umbilical Cord Blood;urban area;Weaning;Woman

PROJECT_TITLE: Early life aflatoxin B1 exposure and epigenetic programming in Nigerian Newborns

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-L(57)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Estrogen;Neurodegenerative;Neurosciences;Women's Health Research

ORG_CITY: MORGANTOWN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: NARRATIVE: There is increasing evidence that there are clear differences between men and women in cognitive impairment particularly Alzheimer’s Disease. Mid-life levels of obesity, diabetes, hypertension, and particularly high cholesterol are risk factors for cognitive impairment and dementia in old age, and they may even cause cognitive decline in young adults. We will feed a high-cholesterol diet to male and female animals as an unconventional, but promising model of late-onset Alzheimer’s Disease, and determine how estrogen and estrogen receptors affect learning and memory and the underlying molecular pathways and brain pathology.

PI_NAMEs: COMBS, COLIN K;SCHREURS, BERNARD G. (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: 27-hydroxycholesterol;Adult;Affect;Agonist;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;anastrozole;Animals;ATP binding cassette transporter 1;Behavioral;beta amyloid pathology;Biological;biological research;Brain Pathology;Cholesterol;Clinical Trials;clinically relevant;Cognition;cognitive performance;Data;Dementia;density;Deposition;Diabetes Mellitus;Diet;dietary;Disease;Electrophysiology (science);ESR1 gene;Estrogen Receptor 2;Estrogen Receptors;Estrogens;experimental study;Female;Genes;Genetic Transcription;GPER gene;Hippocampus;human old age (65+);hypercholesterolemia;Hypertension;Impaired cognition;improved;Incidence;indexing;Infusion procedures;inhibitor;Knowledge;Late Onset Alzheimer Disease;Learning;male;Male Castration;Measures;member;Membrane;Memory;Memory impairment;men;middle age;mild cognitive impairment;Mitochondria;Modeling;Molecular;mouse model;Nerve Degeneration;Neuronal Plasticity;Neurophysiology - biologic function;neuroprotection;Non-Rodent Model;Obesity;Oryctolagus cuniculus;Ovariectomy;Pathology;Pathway interactions;Patients;Peripheral;Positioning Attribute;Postmenopause;postsynaptic;postsynaptic density protein;Prefrontal Cortex;presynaptic;programs;Property;protein expression;Proteins;Research;Risk;Risk Factors;Role;Selective Estrogen Receptor Modulators;Serum;Severities;Sex Differences;Signal Pathway;Symptoms;Synapses;Synaptic plasticity;tau Proteins;Techniques;Testing;Transgenic Mice;Woman;young adult

PROJECT_TITLE: Impact of sex differences on molecular determinants of AD risk and responsiveness to treatment

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

PI_NAMEs: NESVIZHSKII, ALEXEY I (contact)

PROJECT_TERMS: Address;Bioinformatics;Biological;Biological Assay;Biological Markers;Biology;cancer biomarkers;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;cancer initiation;Clinical Research;Computer software;cost efficient;crosslink;data acquisition;Development;Developmental Therapeutics Program;drug discovery;Funding;Glossary;Goals;Hematopoiesis;High Pressure Liquid Chromatography;Human Resources;Immunology;Informatics;instrumentation;Knowledge;Leadership;Malignant Neoplasms;Mass Spectrum Analysis;member;Methods;Michigan;Names;Neoplasm Metastasis;Pathway interactions;Population Sciences;Post-Translational Protein Processing;programs;protein expression;Proteins;Proteome;Proteomics;Proteomics Shared Resource;Research;Resolution;Resources;Role;Sampling;Services;Signal Transduction;System;Technical Expertise;Technology;therapeutic target;Translational Research;tumor microenvironment;Universities

PROJECT_TITLE: Proteomics (PRO)


PI_NAMEs: KELLER, EVAN T (contact)

PROJECT_TERMS: analytical method;Architecture;Bioinformatics;Biological Markers;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;Cell Nucleus;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical Research;cost effective;Developmental Therapeutics Program;Disease;DNA;DNA sequencing;Formalin;Freezing;Glossary;Goals;Hematopoiesis;Heterogeneity;Immunology;Individual;Malignant Neoplasms;member;Michigan;Monitor;multiple omics;Names;Phenotype;Population Sciences;programs;Proteins;Quality Control;Research;Resolution;Resource Sharing;response;RNA;Sampling;Services;Signal Transduction;single-cell RNA sequencing;Source;success;Therapeutic;therapy outcome;tissue fixing;Tissues;tool;transcriptome;transcriptomics;Translational Research;tumor;Tumor Biology;tumor heterogeneity;tumor microenvironment;Universities

PROJECT_TITLE: Single Cell Spatial Analysis


ADMINISTERING_IC: DC

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: MODALITY.AI , INC

PHR: PUBLIC HEALTH RELEVANCE: One of the most devastating effects of Amyotrophic Lateral Sclerosis (ALS) is the progressive loss of speech function. By creating a digital tool for assessing speech on a patient’s own computer or mobile device, Modality.AI and MGH of Health Professionals aim to develop a telehealth service to determine communication status in patients with ALS and document treatment outcomes in a real-world setting. Ultimately, this technology aims to improve diagnosis for patients with ALS, decrease costs for patients and healthcare providers, and provide access to accurate speech assessments while eliminating the need for travel.

PI_NAMEs: GREEN, JORDAN R (contact);RAMANARAYANAN, VIKRAM

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: accurate diagnosis;Address;Adoption;Adult;Adverse effects;Affect;ALS patients;Amyotrophic Lateral Sclerosis;Area;Artificial Intelligence;Assessment tool;behavioral clinical trial;Caring;Cellular Phone;Characteristics;Clinical;Clinical Trials;cohort;commercialization;Communication;Computers;cost;COVID-19 pandemic;Data;Data Analyses;Data Collection;data quality;Deglutition;Development;Devices;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic tests;diagnostic tool;digital;digital tool;Disease;Early Diagnosis;Effectiveness;Ensure;experience;Goals;handheld mobile device;Head and neck structure;health care delivery;Health Personnel;Health Professional;Health Services;Healthcare;Heterogeneity;Impairment;improved;Individual;innovative technologies;instrumentation;Internet;Intervention;Intuition;Laboratories;Language;laptop;Learning;Licensing;limb loss;Machine Learning;Marketing;Measurement;Measures;Modality;Monitor;Motor;Motor Neuron Disease;National Institute on Deafness and Other Communication Disorders;Neurodegenerative Disorders;Neurologic;novel;Online Systems;Operating System;Outcome;Palliative Care;Participant;Pathologist;Patients;Pattern;Performance;Persons;pharmacologic;Pharmacologic Substance;Phase;programs;Psychological Impact;public health relevance;Quality of Care;Quality of life;remote administration;Research;Resolution;response;Risk;risk mitigation;routine practice;Running;Sensitivity and Specificity;Severities;Small Business Technology Transfer Research;Social Impacts;Speech;speech accuracy;standard care;Strategic Planning;success;Surveys;Symptoms;System;Tablets;Target Populations;Technology;telehealth;Testing;Time;tool;Training;Travel;Treatment outcome;Underserved Population;United States National Institutes of Health;usability;Video Recording;Vulnerable Populations;Work

PROJECT_TITLE: A digital tool for monitoring speech decline in ALS


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Natural Products;Neurodegenerative;Neurosciences;Substance Misuse

ORG_CITY: EAST LANSING

ORG_DEPT: PHARMACOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: NARRATIVE This project investigates the effects of cannabis, and specifically the frequency of cannabis use, on HIV associated inflammation and how it relates to HIV-associated neurocognitive disorder.

PI_NAMEs: KAMINSKI, NORBERT E (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Agonist;AIDS dementia;Anti-Inflammatory Agents;antiretroviral therapy;Astrocytes;Automobile Driving;Autopsy;Blood - brain barrier anatomy;brain tissue;Cannabidiol;Cannabinoids;Cannabis;Cell Death;cell type;Cells;Chronic;chronic infection;CNR1 gene;CNR2 gene;Coculture Techniques;Event;Exhibits;FCGR3B gene;Frequencies;Glutamates;Health;HIV;HIV Infections;HIV-associated neurocognitive disorder;Human;IL18 gene;Immunohistocytochemistry;Impairment;in vivo;Individual;Infiltration;Inflammasome;Inflammation;Inflammatory;Interleukin-1 beta;Life Expectancy;Ligands;marijuana use;Mediating;microbial;migration;monocyte;Neurocognitive Deficit;neuroinflammation;Neurons;neurotoxic;Pathway interactions;Patients;Persons;Property;Proteins;Regulation;Reporting;response;Role;Surface;systemic inflammatory response;Testing;Tetrahydrocannabinol;transcriptomics

PROJECT_TITLE: Cannabis use frequency and its impact on monocyte-mediated inflammation in HIV patients


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Current therapies aimed at heart failure, a global health problem, have been directed mainly at end-stage disease. We seek to better understand the processes that occur early in the genesis of heart failure in order to identify new therapeutic strategies aimed at early stage disease. In this project, we will focus on the observation that the early stage failing heart becomes “energy-starved” due to abnormalities in proteins involved in converting fuels to a usable energy source.

PI_NAMEs: MUOIO, DEBORAH M (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Animal Model;aorta constriction;ascending aorta;Bypass;Carbon;Cardiac;Cardiac Myocytes;Cardiomyopathies;chromatin immunoprecipitation;Chronic;Coenzyme A;cofactor;comparative;Complex;deep sequencing;design;Development;dihydroorotate;Disease;Down-Regulation;Echocardiography;end stage disease;Energy-Generating Resources;Enzymes;Event;fatty acid oxidation;Fatty Acids;Functional disorder;Funding;Gene Deletion;Generations;Genetically Engineered Mouse;Genomics;global health;Glucose;Growth;Heart;Heart failure;heart function;Heart Hypertrophy;Homeostasis;Human;Hypertrophy;Isotopes;Ketone Bodies;Left;Link;long chain fatty acid;Maintenance;Mass Spectrum Analysis;Measures;Metabolic;metabolomics;Mitochondria;Modeling;Mus;Mutation;NADH dehydrogenase (ubiquinone);NCOR1 gene;Nodal;novel;novel therapeutic intervention;NRIP1 gene;Oxidants;oxidation;Oxidation-Reduction;Palmitates;Pathogenesis;Pathologic;Pathway interactions;Pattern;Phenotype;Physiologic intraventricular pressure;preservation;pressure;prevent;Process;Production;Proteins;Proteomics;Pyrimidine;respiratory disorder diagnosis;Respiratory physiology;response;Role;Series;Source;Starvation;Structure;Supplementation;Testing;therapeutic candidate;transcriptome sequencing;Ubiquinone;usability;Ventricular;Ventricular Dysfunction;Work

PROJECT_TITLE: Probing the Role of Mitochondrial Short-chain Carbon Homeostasis in the Hypertrophied and Failing Heart

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ORG_CITY: MINNEAPOLIS

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE The University of Minnesota Medical Scientist Training Program (MD/PhD) provides a rigorous, supportive program of study for an outstanding and diverse group of students who will become leading physician scientists. By combining medical training with research training that will lead to new scientific discoveries, this integrated training program will help meet the nation’s critical need for investigators who can successfully translate scientific discoveries into new preventive strategies and therapies that will improve the lives of patients.

PI_NAMEs: SHIMIZU, YOJI  (contact)

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Excessive use of prescribed opioids during and after major surgery is a significant contributor to persistent opioid use, misuse and ongoing opioid epidemic, which are recently worsened by the pandemic. The proposed research has significant public health relevance because it aims to reduce surgical pain and opioid use with a promising non-pharmacological tool, Auriculotherapy, that stimulates ear nerves. By proactively reducing surgical pain, postoperative opioid use and opioid-related serious adverse effects with Auriculotherapy, this research will enable the best-in-class post-surgical pain and opioid-related outcomes in millions of Americans undergoing painful surgeries every year while minimizing the nation’s opioid epidemic burden.

PI_NAMEs: CHELLY, JACQUES E. (contact);SADHASIVAM, SENTHILKUMAR

PROGRAM_OFFICER_NAME: REICHEL, CARMELA MARIE

PROJECT_TERMS: Abdominal Pain;Absence of pain sensation;Acupuncture Therapy;addiction;Adult;Adverse effects;Affect;American;Anxiety;anxiety reduction;Blinded;Cell Nucleus;Cervical;Colorectal Surgery;Conduction Anesthesia;Controlled Clinical Trials;COVID-19;Cranial Nerves;Data;Dependence;Development;Devices;Dose;Ear;Effectiveness;effectiveness evaluation;efficacy evaluation;Elderly;Face;fighting;Genetic;glossopharyngeal;Goals;Guidelines;Hospitals;Human;human old age (65+);improved;Inflammatory;insight;Knowledge;Limbic System;Mental Depression;Mental Health;Mood Disorders;multidisciplinary;Nerve;Nerve Plexus;neural;non-opioid analgesic;Nonpharmacologic Therapy;novel;older patient;Operative Surgical Procedures;Opioid;opioid epidemic;opioid mortality;opioid sparing;opioid use;opioid use disorder;opioid withdrawal;Outcome;Overdose;overdose death;Pain;pain relief;pandemic disease;Pathway interactions;Patients;Perioperative;Pilot Projects;Placebo Control;placebo controlled study;placebo group;Placebos;Play;Positioning Attribute;Postoperative Pain;Postoperative Period;prescription opioid;Property;prospective;psychologic;psychological symptom;public health relevance;Questionnaires;Randomized;randomized, clinical trials;Recommendation;Recording of previous events;Research;Risk;Risk Factors;Rodent;Role;Safety;Statutes and Laws;Surgical Oncology;surgical pain;Techniques;Testing;tool;Training;treatment duration;Trigeminal System;Withdrawal Symptom

PROJECT_TITLE: Reduction of opioid requirement associated with Auriculo-nerve stimulation following open surgery

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Cancer

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE  The Cancer Biology Training Program (CBTP) requests support to provide trainees with mentored research, research education and professional and career development. The overall goal of this T32 Cancer Biology Training Program application is to educate researchers who are prepared to advance research on the molecular and genomic causes, progression, treatment and relapse of human malignancies to reduce cancer-related disease and death.

PI_NAMEs: LEE, NORMAN H (contact);SETO, EDWARD

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Cancer Biology;Training Programs

PROJECT_TITLE: Cancer Biology Training Program (CBTP)

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Lung;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: GAINESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Cervical spinal injury leads to paralysis and possible death from respiratory failure or related comorbidities, thus our goal is to restore respiratory function in a rat model of upper cervical spinal cord injury by utilizing closed- loop cervical spinal epidural stimulation. We propose that induction of respiratory neuroplasticity may rely on activity-dependent upregulation of key neurotrophic factors (e.g. BDNF, TrkB) within phrenic motor neurons, thereby enhancing ventilatory capacity beyond the period of stimulation (i.e. plasticity). Through a detailed understanding of these mechanisms, this project may lead to novel therapies to extend and improve life for patients with cervical spinal cord injury by preserving breathing.

PI_NAMEs: DALE, ERICA ARDEN (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Acute;Address;Affinity;Animals;awake;Biological;Brain-Derived Neurotrophic Factor;Breathing;Cervical;Cervical spinal cord injury;Cervical spine;Cessation of life;Chest;Chronic;Clinical;comorbidity;Contralateral;Data;Development;Devices;Electric Stimulation;Elements;Failure;functional improvement;Future;Goals;improved;in vivo;Injury;innovation;insight;interdisciplinary approach;Investigation;Life;Literature;Modeling;mortality;Motor;motor function improvement;Motor Neurons;motor recovery;neural;neural circuit;Neuronal Plasticity;Neurons;neurotrophic factor;novel;novel therapeutics;Paralysed;Pathway interactions;Patients;Phase;Play;Plethysmography;preservation;Rattus;receptor;Recovery;Recovery of Function;Rehabilitation Outcome;Reporting;Research;Research Personnel;respiratory;Respiratory Diaphragm;Respiratory Failure;Respiratory physiology;response;Rodent;Sensory;Signal Transduction;Spinal;Spinal cord injury;Spinal Injuries;Stimulus;Synapses;Synaptic plasticity;System;Testing;Therapeutic;Up-Regulation;Ventilator

PROJECT_TITLE: Cervical Epidural Stimulation and Respiratory Motor Plasticity

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Neurosciences;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Encephalitic alphaviruses such as Eastern equine encephalitis virus (EEEV) are highly lethal pathogens with no current FDA-approved therapeutics or vaccines. Antibody-mediated neutralization and protection of EEEV has not been well defined, and we still lack fundamental knowledge of important antigenic sites that inform vaccine design. The research we are proposing will provide important information defining the humoral immune response and mechanistic correlates of protection for alphavirus infections including engineered antibodies that transport to brain.

PI_NAMEs: CROWE, JAMES E (contact);DIAMOND, MICHAEL S;KLIMSTRA, WILLIAM B

PROGRAM_OFFICER_NAME: DYALL, JULIE

PROJECT_TERMS: Active Biological Transport;Aedes;Aerosols;Affect;Affinity;Alanine;Alpha Virus;Alphavirus Infections;Animal Model;Animals;Antibodies;antibody engineering;Antigens;Arboviruses;Binding;Biological Assay;Biological Models;Biological Products;Biological Warfare;Bioterrorism;Birds;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;Brain Injuries;Brain region;Cell Culture Techniques;Cells;Central Nervous System;Characteristics;Charge;climate change;Clinical;Community Hospitals;Coupled;Culex (Genus);Culicidae;Death Rate;Development;Diagnosis;Diamond;Disease;disease transmission;Eastern Equine Encephalitis Virus;effective therapy;Engineering;env Gene Products;enzootic;Epitope Mapping;Epitopes;Equus caballus;Escape Mutant;experience;experimental study;Family;FDA approved;Frequencies;Future;Genes;Genetic;Goals;Human;human monoclonal antibodies;Imaging Techniques;Immune response;Immunity;Immunoglobulin G;Immunologics;In Vitro;in vivo;in vivo imaging;Infection;inhibiting antibody;innovation;insight;Knowledge;Laser Scanning Confocal Microscopy;Measurement;Measures;Mediating;medical countermeasure;Membrane Fusion;Molecular;Monoclonal Antibodies;Monoclonal Antibody Therapy;Morbidity - disease rate;mortality;mosquito-borne;Mutagenesis;Mutation;Nature;Neurologic;neutralizing antibody;neutralizing monoclonal antibodies;new technology;next generation sequencing;novel;pathogen;Pathogenesis;Pathogenicity;Predisposition;prevent;Prevention;Property;prophylactic;Prophylactic treatment;Proteomics;rational design;receptor;Reporting;Research;Research Personnel;Resistance;Resolution;Role;Route;rural setting;Scanning;Scientist;Secondary to;Site;Somatic Mutation;Specificity;Structure;Survivors;synergism;Testing;Therapeutic;Therapeutic Effect;Therapeutic Monoclonal Antibodies;Therapeutic Uses;Togaviridae;Translating;transmission process;Treatment Efficacy;United States;Vaccine Design;Vaccines;Variant;vector;Viral;viral fitness;viral resistance;Virus;Virus Diseases;virus testing;Work

PROJECT_TITLE: Human Monoclonal Antibodies for Encephalitic Alphaviruses


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Organ Transplantation;Pneumonia and Influenza;Prevention;Transplantation;Vaccine Related

PHR: Narrative Influenza virus is a significant pathogen in solid organ transplant (SOT) patients, but these individuals respond poorly to standard-dose (SD) inactivated influenza vaccine (IIV). Studies suggest that two doses of SD-IIV or one dose of high-dose (HD-IIV) is superior to one dose of SD-IIV; however, this has not been tested in the early post-transplantation period when SOT recipients are at highest risk of severe influenza disease and complications. This study aims to find the optimal influenza vaccine strategy by comparing one dose of HD-IIV, two doses of SD-IIV, or two doses of HD-IIV over one influenza season in adult, kidney, heart, and/or liver SOT recipients in the early transplant period.

PI_NAMEs: HALASA, NATASHA BASSAM (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Ache;Address;Adult;Adverse event;Alabama;Antigens;B-Lymphocyte Subsets;B-Lymphocytes;CD4 Positive T Lymphocytes;Cellular Assay;Cytometry;Disease;Dose;Enrollment;Evaluation;Event;exhaustion;Fatigue;Fever;Frequencies;Headache;Heart;Hemagglutination;high risk;human old age (65+);immune activation;Immune response;Immunocompromised Host;immunogenicity;Immunologics;Immunophenotyping;immunosenescence;Immunosuppression;Impairment;Individual;Induration;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;influenza virus vaccine;influenzavirus;Injections;Kidney;Knowledge;Lead;Licensing;Liver;Malaise;Measures;Medical center;medical schools;Myalgia;Nausea;organ transplant recipient;Organ Transplantation;Pain;pathogen;Phase;phase II trial;Phenotype;Placebos;Population;post-transplant;Prevention strategy;primary endpoint;Randomized;Recommendation;Redness;Reporting;response;Safety;seasonal influenza;Seasons;secondary endpoint;seroconversion;Severities;Site;Solid;standard measure;Swelling;T-Lymphocyte;Testing;Time;Transplantation;trial comparing;Universities;Vaccination;vaccination strategy;vaccine immunogenicity;vaccine response;vaccine strategy;Vaccines;Vomiting;Vulnerable Populations;Washington

PROJECT_TITLE: Comparison of High vs. Standard Dose Influenza Vaccines in Adult Solid Organ Transplant Recipients


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Public Health Relevance: This study will determine preliminary efficacy of a multi-level intervention to improve HIV outcomes among transgender women by reducing stigma and increasing cohesion. Study findings will also provide insights into the relative contributions of each intervention component to address stigma and develop social cohesion.

PI_NAMEs: BARRINGTON, CLARE L (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Address;Adherence;Adult;Affect;Appointment;Area;arm;Behavior Therapy;Belief;Buffers;care outcomes;Caribbean region;Caring;cisgender;Clinic;cohesion;Communities;comparison intervention;Consultations;Continuity of Patient Care;Control Groups;Counseling;Discrimination;Dominican Republic;Dose;Education;Emotional;Exclusion;experience;Feeling;female sex worker;Focus Groups;Fright;gender affirmation;Health;Health education;HIV;improved;Individual;insight;internalized stigma;Interruption;Intervention;intervention participants;Interview;Latin America;maltreatment;Modeling;Modification;Outcome;Participant;Pathway interactions;peer;Population;Prevalence;Process;Provider;public health relevance;Randomized;randomized trial;Recommendation;Reporting;Resources;response;scale up;self esteem;sex;Site;social cohesion;social determinants;social stigma;staff intervention;substance use;Surveys;Training;transgender;transgender women;Treatment outcome;trend;Trust;Viral;Viral Load result;Woman;Work

PROJECT_TITLE: Piloting a multi-level intervention to promote viral suppression among transgender women living with HIV

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: CHICAGO

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Based at the University of Chicago, this cross-disciplinary T32 program leverages the intellectually rich environment on campus and its resources in immunology, medicine, molecular engineering, and data science to train postdoctoral fellows in the rapidly emerging field of Immunoengineering. Designed for early postdoctoral bioengineers or immunologists, the training plan funds participation in an immersive short course in each other's fields, as well as elective workshops and outreach opportunities to improve teaching & science communications skills, and grant- and proposal-writing abilities. Postdoctoral fellows will be mentored by a panel of immunologists and bioengineers to develop novel collaborative projects that address today's biggest unanswered questions at the interface and translate these insights into new solutions that improve health, lengthen life, and reduce illness and disability.

PI_NAMEs: ALEGRE, MARIA-LUISA ;SWARTZ, MELODY ANN (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TITLE: Immunoengineering Postdoctoral Training Program - Resubmission - 1

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Nerve signals originating in the rod and cone photoreceptors are processed by circuits in the inner retina to give rise to separate visual streams that carry information about, for example, object motion and color. These circuits become disrupted following photoreceptor degeneration in both genetic and age-onset disease. Our work will help to define the wiring and functions of these circuits in the healthy retina and will provide the background for understanding circuit changes in the diseased state.

PI_NAMEs: DEVRIES, STEVEN H (contact);ZHU, YONGLING

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Age of Onset;Amacrine Cells;Anatomy;Attention;cell type;Cells;Characteristics;Code;Color;Color Visions;Complex;Cone;Cre driver;Dendrites;Disease;Electrophysiology (science);experimental study;Functional Imaging;ganglion cell;Genetic;Goals;HDAC1 gene;Health;Image;Individual;Label;Light;Light Cell;Maps;Monitor;Mus;neural circuit;neuronal cell body;neurotransmission;object motion;Onset of illness;Pattern;photoreceptor degeneration;postsynaptic;presynaptic;presynaptic neurons;Presynaptic Terminals;Process;Property;Proteins;rabies viral tracing;Rabies virus;receptive field;response;Retina;Retinal Cone;Retinal Ganglion Cells;Rod;Role;signal processing;Signal Transduction;spatiotemporal;Spermophilus;Stimulus;Stream;superior colliculus Corpora quadrigemina;superresolution microscopy;Surface;Synapses;System;Techniques;Time Study;transmission process;uptake;Vertebrate Photoreceptors;Viral;Virus;Vision;Visual;visual stimulus;Work

PROJECT_TITLE: Signal Processing in the Inner Retina

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


ORG_CITY: ROCHESTER

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project narrative Lipid droplets are cellular organelles that store fat and are misregulated in many human diseases. They also have a major function in protein handling, including for certain viral and nuclear proteins. This project analyzes how lipid droplets exchange proteins between each other, how cells turn this exchange on and off, and how it affects cellular function, potentially uncovering new principles of how lipid droplets promote health and disease.

PI_NAMEs: WELTE, MICHAEL ANDREAS (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Affect;Affinity;Binding;Biological;blastocyst;CDC2 gene;Cell Cycle;Cell Nucleus;Cell Physiology;Cells;Chromatin;Chromatin Modeling;Cytoplasm;Cytosol;Data;Defect;Development;Disease;dosage;Drosophila genus;Embryo;Embryonic Development;Fatty acid glycerol esters;Fertilization;Future;Gene Expression Regulation;Generations;Genetic Transcription;Goals;Grant;Health;Health Promotion;Histone H2A;Histones;Homeostasis;human disease;Importins;In Vitro;in vivo;insight;Laboratories;Life Cycle Stages;lipid metabolism;Lipids;Measures;Mediating;Membrane;Metabolism;Modeling;Molecular Chaperones;mutant;Nuclear;Nuclear Import;Nuclear Proteins;Nurses;Oocytes;Oogenesis;Organelles;Ovary;Phosphorylation;Physiological;Play;premature;prevent;Process;Protein Dephosphorylation;Protein Dynamics;Proteins;Quantitative Reverse Transcriptase PCR;recruit;Regulation;Role;Signal Transduction;Site;Testing;Time;Transcript;transcription factor;transcriptome;transcriptome sequencing;Viral;Viral Proteins;Work

PROJECT_TITLE: Lipid droplets as protein sequestration sites

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ORG_CITY: CLEMSON

ORG_DEPT: PHYSICS

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Aggregation of human islet amyloid polypeptide (hIAPP) is associated with type-2 diabetes (T2D). We propose to uncover mechanisms of hIAPP aggregation and cross-interactions with other amyloid proteins, and design engineered nanoparticles to mitigate aggregation and the associated toxicity. Outcome of the proposed research will help better understand disease mechanisms of T2D and pathological correlations with other amyloid diseases, and aid in the design of anti-amyloid nanomedicine against T2D. 1

PI_NAMEs: DING, FENG  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Alzheimer's Disease;Amyloid;Amyloid Fibrils;Amyloid Proteins;Amyloidosis;Artificial nanoparticles;Bacterial Infections;base;Beta Cell;beta pleated sheet;Biological;Cell Death;Cell membrane;Computer Models;Cryoelectron Microscopy;cytotoxicity;design;Development;Diabetes Mellitus;diabetic;Disease;dysbiosis;Engineering;Environment;Goals;Human;Immune response;improved;In Vitro;inhibitor;insight;Insulin;islet amyloid polypeptide;Length;Mediating;Membrane;Molecular;monomer;nanomedicine;nanoparticle;nanotoxicity;Nature;Neurodegenerative Disorders;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Outcome;Parkinson Disease;Pathologic;peptide hormone;prevent;Process;Proteins;Research;Risk Factors;Specificity;structural biology;Structure;System;Therapeutic;Time;Toxic effect;Validation

PROJECT_TITLE: Inhibition of Human Islet Amyloid Polypeptide Aggregation

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative  Protein ADP-ribosylation plays important roles in a variety of biological processes and is associated with many human diseases. We are aimed to develop innovative chemical tools to determine the functions and roles of this key type of post-translational modification in physiology and pathophysiology.

PI_NAMEs: ZHANG, YONG  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Address;Adenosine Diphosphate Ribose;ADP Ribose Transferases;ADP ribosylation;Area;Biological Process;Biology;Cell Physiology;Chemicals;Chemistry;Complex;Development;Disease;Dissection;Event;Functional disorder;Goals;Health;Human;human disease;Individual;innovation;Maps;Mediating;new therapeutic target;Nicotinamide adenine dinucleotide;novel;novel diagnostics;Pathogenesis;Pathway interactions;Physiological;Physiology;Play;Post-Translational Protein Processing;Process;Proteins;Reader;Research;Role;Signal Transduction;Technology;tool;Work

PROJECT_TITLE: Chemistry and Biology of ADP-Ribosylation-Dependent Signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ORG_CITY: WORCESTER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative This application seeks to discover and characterize the molecular mechanisms controlling the synthesis and remodeling of bacterial cell envelope polymers called teichoic acids and define how this regulation is corrupted by antibiotics to trigger cell lysis using the pathogen Streptococcus pneumoniae as a model system. The research proposed here will yield a mechanistic understanding of how these cell envelope biogenesis and remodeling systems affect bacterial physiology and uncover new ways to inhibit these processes for the development of therapeutics against infections caused by S. pneumoniae and related pathogens. Since many virulence determinants are embedded within or secreted across the cell envelope, our results will also impact pathogenesis research.

PI_NAMEs: FLORES-KIM, JOSUE  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Affect;antibiotic tolerance;Antibiotics;Bacteria;Bacterial Physiology;Biogenesis;Biological Models;Cell division;Cell Enlargement;cell envelope;cell growth;Cell Shape;Cell Wall;Cells;Cellular Morphology;Complex;Cytolysis;Enzymes;Equilibrium;Goals;Growth;Health;Human;Infection;insight;Laboratories;Link;lipoteichoic acid;Maintenance;Membrane;model organism;Molecular;Multi-Drug Resistance;N-Acetylmuramoyl-L-alanine Amidase;new therapeutic target;novel;Osmosis;pathogen;Pathogenesis;Pathway interactions;Peptide Hydrolases;Peptidoglycan;Physiological;Polymers;Post-Translational Protein Processing;Process;Proteolysis;Regulation;Research;respiratory pathogen;Role;Signal Transduction;Streptococcus pneumoniae;Structure;System;Teichoic Acids;therapeutic development;Therapeutic Intervention;Virulence

PROJECT_TITLE: Discovery and characterization of bacterial cell envelope assembly and remodeling networks that modulate tolerance to antibiotics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_DEPT: PEDIATRICS

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Narrative Cervical injury to the spinal cord results in dimished forelimb function. We have recently identified that the C3-C4 propriospinal neurons, which connect to the lateral reticular nucleus, can promote recovery of forelimb function after cervical lesions and rehabilitative training. We hypothesize that rehabilitation promotes recovery by inducing sprouting along the propriospinal- lateral reticular formation-cerebellar-brainstem loop and important pathway that normal functions to correct forelimb-patterning errors during the movement.

PI_NAMEs: SMITH, GEORGE M (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Ablation;Affect;Animals;Automobile Driving;Autonomic Dysfunction;Axon;Back;Behavior;Brain Stem;Cell Nucleus;Cerebellar Nuclei;Cerebellum;Cervical;Cervical spinal cord injury;Chest;Compensation;Conscious;Corticospinal Tracts;Data;Digit structure;Dorsal;dorsal column;Efferent Pathways;Food;Forelimb;Genetic;Goals;grasp;Hand;Human;improved;Injury;injury recovery;Instruction;Lateral;Lesion;Life Style;Limb structure;Locomotion;Maps;Mediating;Memory;Motor;motor control;Motor Cortex;motor learning;Motor Neurons;motor skill learning;Movement;Muscle;Neurons;Pathway interactions;Patients;Pattern;Population;preservation;Rattus;Recovery;Recovery of Function;Recovery Support;Red nucleus structure;Rehabilitation therapy;Reticular Formation;Retrieval;Role;Sensory;sensory feedback;Severities;Signal Transduction;skills;Spinal Cord;Spinal cord injury;Structure of rubrospinal tract;Study models;success;System;Tactile;Time;Tracer;Training;Training Support;Unconscious State

PROJECT_TITLE: Adaptation of internal motor copy circuits in recovery after spinal cord injury.

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. It will also investigate the specific dynamic interactions among these phenomena in daily life and how they, as well as the neurobehavioral predictors, are linked to day-to-day functioning. The findings of this project could provide novel targets for therapeutics aimed at improving functioning and overall quality of life in individuals with serious mental illnesses, as well as quantitative phenotypes for use in genetic investigations and early detection efforts.

PI_NAMEs: FULFORD, DANIEL C;HOLT, DAPHNE J (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Address;Affect;Amygdaloid structure;Basal Ganglia;Behavior;behavior prediction;Behavioral;Cellular Phone;design;digital assessment;disability;Disease;Early Diagnosis;Ecological momentary assessment;experience;Face;follow-up;functional disability;functional improvement;Functional Magnetic Resonance Imaging;General Population;Genetic;Hippocampus;Impairment;improved;in vivo;Individual;Individual Differences;insight;Intervention;intimate behavior;Investigation;Knowledge;Life;Link;Loneliness;longitudinal design;Measurement;Measures;medial temporal lobe;mobile computing;Modeling;Monitor;Mood Disorders;mortality;Motivation;neural;neural correlate;neural model;neurobehavioral;neurobiological mechanism;neuroimaging;Neurophysiology - biologic function;new therapeutic target;novel;novel strategies;Participant;Personal Space;personalized intervention;Persons;Phenotype;Play;predicting response;prevent;Process;psychologic;psychosocial;Psychotic Disorders;Quality of life;Reporting;Research;response;Rewards;Schizophrenia;severe mental illness;smartphone based assessment;social;Social Behavior;social contact;social determinants;Social Interaction;Social isolation;Social Network;Social Perception;Stimulus;System;Testing;Thalamic structure;Time;trait;Variant;Work

PROJECT_TITLE: Neurobehavioral mechanisms of social isolation and loneliness in serious mental illness


NIH_SPENDING_CATS: Bipolar Disorder;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences

ORG_DEPT: PSYCHIATRY

PHR: PUBLIC HEALTH RELEVANCE Bipolar disorder is a devastating disease that impacts the lives of millions of people. The identification of more targeted treatments will help to minimize side effects and improve efficacy of therapeutic results. These studies will help pave the way towards the identification and development of these targeted treatments to stabilize mood and improve the lives of those suffering from this disease.

PI_NAMEs: MCCLUNG, COLLEEN A (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Acute;Animal Model;Animals;Antibodies;Anticonvulsants;Behavior;Behavioral;behavioral phenotyping;Binding;Bipolar Disorder;bipolar mania;Brain;Cell Separation;Cells;chromatin immunoprecipitation;Corpus striatum structure;deep sequencing;Development;Disease;Dopamine;dopaminergic neuron;Drug Prescriptions;efficacious treatment;Electrodes;Electrophysiology (science);Funding;Future;gamma-Aminobutyric Acid;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Goals;Grant;HDAC1 gene;Histone Acetylation;Histone Deacetylase;histone deacetylase 2;Histone Deacetylase Inhibitor;Human;improved;in vivo;inhibitor;knock-down;Location;Malignant Neoplasms;Manic;Measures;Mental disorders;Molecular;Molecular Target;Moods;mouse model;Mus;Mutation;Names;Neurons;new therapeutic target;overexpression;patch clamp;Persons;Pharmaceutical Preparations;Pharmacology Study;Phase;Phenotype;prevent;protein expression;Protein Inhibition;Proteins;Proteomics;public health relevance;Regulation;response;Rest;RNA Viruses;Series;side effect;Signal Transduction;small hairpin RNA;System;targeted treatment;Therapeutic;therapeutic candidate;Therapeutic Effect;Therapeutic Studies;therapeutic target;Therapeutic Uses;transcriptome sequencing;transmission process;Treatment Efficacy;treatment response;valproate;Valproic Acid;Ventral Tegmental Area

PROJECT_TITLE: Consequences of HDAC2 inhibition in VTA-NAc circuitry

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE The goal of the proposed research is to explain the underlying mechanisms for a fundamental feature of intelligent behavior, compositionality, or the brain’s remarkable ability to solve new problems by actively creating new cognitive strategies based on combining simpler previously learned strategies in new ways. This research is relevant for understanding what goes wrong in cognitive disorders of planning and decision-making.

PI_NAMEs: TIAN, LUCAS Y. (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TITLE: Investigating Symbolic Computation in the Brain: Neural Mechanisms of Compositionality

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: We proposal to use fertilization in the unicellular green alga Chlamydomonas as a model system to study conserved mechanism of ciliary signaling and the gamete membrane fusion reaction. We will determine the cellular and molecular mechanisms that underlie coupling between the cilium and the cytoplasm cilium generated signaling. And, we will use our recent discovery that gamete lipid bilayer merger depends on an ancient class II fusion protein as the foundation for a more complete molecular understanding of gamete fusion.

PI_NAMEs: SNELL, WILLIAM J (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Adenylate Cyclase;adhesion receptor;Adhesions;Affect;Africa;Apical;Automobile Driving;Binding;Binding Proteins;Biochemical;Biological;Biological Models;Body System;Cell Adhesion Molecules;Cell Communication;Cell Fractionation;Cell fusion;Cell membrane;Cell Wall;Cell-Cell Adhesion;Cells;Chimeric Proteins;Chlamydomonas;Chlamydomonas reinhardtii;Cilia;ciliopathy;Communication;Complement;Concentration Camps;Coupling;Culicidae;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cyclic Nucleotides;Cytoplasm;Dengue;Development;Disease;Dissection;erection;Erinaceidae;Event;Evolution;Fertilization;field study;Foundations;G-Protein-Coupled Receptors;Germ Cells;Green Algae;Hand;Homologous Gene;Human;Huntingtin-Associated protein 1;Image;Immunofluorescence Immunologic;Laboratory Study;Learning;Ligands;Link;Lipid Bilayers;Location;Malaria;malaria transmission;malaria transmission-blocking vaccine;male;Mating Types;Mediating;Membrane;Membrane Fusion;Membrane Proteins;Methods;Microtubules;Modeling;Molecular;Organelles;Organism;Partner in relationship;patched protein;Pathway interactions;PDAP2 Gene;Peptides;Phosphorylation;Plasmodium;Process;Property;Protein Family;protein function;Protein Kinase;Protein S;Proteins;Reaction;receptor;Regulation;response;Rest;restraint;Signal Pathway;Signal Transduction;Site;Sperm-Ovum Interactions;Structure;System;Time;trafficking;transmission process;Vertebrates;Vesicle;Virus;ZIKA

PROJECT_TITLE: Conserved mechanisms of ciliary signaling and cell-cell fusion


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Addressing a paucity of training in multilingual research methods, we propose a unique, short-term education program to provide child health researchers with the sensitivity, skills, and knowledge to recruit and engage Limited English Proficiency (LEP) children and families in research. In the US there are approximately 7.8 million children and adolescents with no English-proficient parents, and these children and youth are disproportionately excluded from child health research because of language barriers. By training and supporting a cohort of investigators specializing in multilingual research methods, we hope to enhance the rigor, validity, and generalizability of child health research by making inclusion of LEP children and families the norm rather than the exception.

PI_NAMEs: YUN, KATHERINE M (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Address;Adherence;Adolescent;Advisory Committees;Affect;Anthropology;Asian;Attention;Awareness;Behavioral Research;bilingualism;Biomedical Research;Budgets;career development;Caregivers;Child;Child Health;Civil Rights;Clinical Research;Clinical Trials;cohort;Collaborations;Communication;Communities;Consent;Demography;design;Development;Discipline;Discipline of Nursing;Education;Educational workshop;Enrollment;Environment;Equity;Ethics;Exclusion;Exclusion Criteria;experience;Faculty;Family;Funding;Grant;Health;Individual;instrument;Interview;Justice;Knowledge;Language;Latino;life span;Limited English Proficiency;Linguistics;Maternal and Child Health;Measures;Mediating;Medical;Methods;mid-career faculty;Minority;Monitor;Multilingualism;oral communication;Outcome;Parents;Participant;Pediatric Hospitals;Pediatrics;Peer Review;Pennsylvania;Philadelphia;Policies;Population;Postdoctoral Fellow;Preparation;programs;Protocols documentation;Psychology;recruit;Reproducibility;Research;Research Methodology;Research Personnel;Resources;Sampling;satisfaction;Seasons;skills;Spanish;success;Surveys;symposium;theories;tool;Training;Training Programs;Translations;United States National Institutes of Health;Universities;Video Recording;virtual;webinar;Woman;Work;Writing;Youth

PROJECT_TITLE: Short Course in Multilingual Research Methods

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: NARRATIVE  Exposure to elevated manganese (Mn) induces incurable neurotoxicity in humans that manifests as parkinsonism in adults, and motor and executive function deficits in children. This study will determine the role of Mn excretion in regulating the risks and outcomes of Mn neurotoxicity. Proposed work will also determine whether increasing Mn excretion is a therapeutically-viable strategy for the management of Mn-induced neurological disease.

PI_NAMEs: MUKHOPADHYAY, SOMSHUVRA  (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Address;Adult;Affect;Bile fluid;Biological Assay;Blood;Body Burden;Brain;brain control;Child;Clinical;Clinical Trials;Development;Disease;Dose;drinking water;epidemiology study;Excretory function;Executive Dysfunction;Exhibits;exposed human population;Exposure to;Feces;Future;gastrointestinal system;General Population;Genetic Polymorphism;Genetic Transcription;Genetic Variation;Hepatic;HIF1A gene;High Prevalence;Human;human model;Individual;Inherited;insight;Intestines;Knock-in;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Life;Liver;Liver diseases;loss of function;loss of function mutation;Manganese;Mediating;Metals;Microscopy;Modeling;Molecular;Motor;motor disorder;National Institute of Environmental Health Sciences;Nervous System Disorder;neurobehavioral;neurotoxic;neurotoxicity;Neurotransmitters;novel;novel therapeutic intervention;Occupational Exposure;Oral;Organ;Organism;Outcome;Parkinsonian Disorders;Pathway interactions;Patients;Phase;Play;Population;prevent;protective effect;Regimen;Reporting;Research;response;Risk;Role;Single Nucleotide Polymorphism;Source;Testing;Therapeutic;therapeutically effective;Tissues;Toxic effect;Up-Regulation;Variant;Work

PROJECT_TITLE: Role and mechanisms of excretion in manganese neurotoxicity

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Lung;Sepsis

PHR: Project Narrative Sepsis is a common and life-threatening response to infection that commonly leads to severe injury to the lung and other vital organs. This proposal will define the mechanisms of treatment effect for two therapies for sepsis (acetaminophen and vitamin C) that are being tested in a new clinical trial.

PI_NAMEs: WARE, LORRAINE B (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acetaminophen;Acute;Acute Renal Failure with Renal Papillary Necrosis;Acute Respiratory Distress Syndrome;Affect;Alveolar;Angiopoietin-2;Antibiotics;antimicrobial;ascorbate;Ascorbic Acid;Bicarbonates;Biological;Biological Markers;Blood capillaries;Cardiovascular system;Cells;Cessation of life;Classification;Clinical;clinical efficacy;Clinical Trials;COVID-19;cytokine;Data;design;Distal;Double-Blind Method;Endothelium;Epithelium;F2-Isoprostanes;Functional disorder;Funding;Future;Health Expenditures;Hemeproteins;Hemodialysis;Hemoglobin;Hemoglobin concentration result;Heterogeneity;Human;IL18 gene;IL8 gene;improved;In Vitro;Incidence;Infection;Inflammation;Inflammatory;Injury;Injury to Kidney;Interleukin-1 beta;Interleukin-10;Interleukin-6;Intravenous;kidney dysfunction;LCN2 gene;Life;Lipid Peroxidation;Liquid substance;Lung;Measures;Mechanical ventilation;Mechanical Ventilators;Methods;Modeling;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;novel;Organ;Outcome;Oxidants;oxidation;oxidative damage;Patients;Permeability;Phase;phase 3 study;Phase III Clinical Trials;phase III trial;Phenotype;Placebos;Plasma;Plasma Cells;precision medicine;Predictive Value;prospective;Protein C;Proteins;Pulmonary Inflammation;Randomized;Recovery;Reducing Agents;Regional Perfusion;Research;response;Rest;Sampling;Sepsis;septic patients;severe injury;Site;Subgroup;Supportive care;targeted treatment;Testing;Therapeutic Effect;treatment comparison;treatment effect;treatment group;Tubular formation;urinary;Urine;Vascular Endothelium;Vasoconstrictor Agents;ventilation

PROJECT_TITLE: Mechanisms of organ dysfunction and recovery in the Acetaminophen and Ascorbate Trial in Sepsis


NIH_SPENDING_CATS: Genetics;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE: Our studies are relevant to the development of so-called adipose tissue fibrosis, which is a severe complication that occurs in the fat tissue in obesity and diabetes and interferes with their treatment. The goal is to understand how the factor known as Matrix Gla Protein (MGP) can prevent and limit adipose fibrosis. Such understanding may be used to develop new strategies to specifically target the fat tissue and treat adipose fibrosis.

PI_NAMEs: BOSTROM, KRISTINA I (contact)

PROGRAM_OFFICER_NAME: JAQUISH, CASHELL E

PROJECT_TERMS: Abnormal Endothelial Cell;activin receptor-like kinase 1;Address;adipose derived stem cell;Adipose tissue;Area;Binding Proteins;Blood Vessels;BMP4;BMP7 gene;bone loss;bone morphogenetic protein 4;bone morphogenetic protein receptors;Bone Morphogenetic Proteins;Brown Fat;Cell Culture Techniques;Cell Separation;Cells;Chronic Disease;Complication;Development;Diabetes Mellitus;Disease;Dissection;Endothelial Cells;endothelial stem cell;Endothelium;Excision;experimental study;extracellular;Extracellular Protein;F3 gene;Failure;Fatty acid glycerol esters;Fibrosis;Functional disorder;GDF10 gene;Gene Deletion;Gene Expression Profile;Gene Mutation;Goals;growth differentiation factor 10;Hyperglycemia;Hyperlipidemia;ICAM1 gene;In Vitro;Inflammation;Inflammatory;inhibitor;Knockout Mice;Label;Ligands;Link;lipid biosynthesis;Location;matrix Gla protein;Mediating;Mediator;Mesenchymal;MGP gene;Modeling;Molecular;multipotent cell;Mus;Mutate;Myofibroblast;Normal tissue morphology;novel therapeutic intervention;Obesity;Pathway interactions;Patients;Pattern;Phenotype;Platelet-Derived Growth Factor alpha Receptor;Play;Population;prevent;Process;progenitor;Protein Deficiency;protein expression;Proteins;receptor;Regulation;repaired;Role;Signal Transduction;single-cell RNA sequencing;Sorting;Source;stem cells;Testing;TGF-beta type I receptor;Thermogenesis;Tissues;Transforming Growth Factor beta;Vascularization

PROJECT_TITLE: Mechanism of Matrix Gla Protein (MGP); Adipose Fibrosis

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Urologic Diseases;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Symptomatic pelvic floor disorders occur in 25% of women in the United States. Given their high prevalence, impact on quality of life, and substantial economic costs, well-designed and well-executed clinical trials focused on prevention or evidence-based treatments are desperately needed. The Duke University Medical Center is committed to actively participating in innovative multicenter trials to achieve this goal.

PI_NAMEs: SIDDIQUI, NAZEMA Y (contact)

PROGRAM_OFFICER_NAME: TEPEDE, ABISOLA KAFAYAT

PROJECT_TERMS: Academic Medical Centers;Adverse event;African American;American Indians;Asian;Basic Science;bilingualism;biomedical referral center;Bladder;Botox;Caring;Clinical;clinical care;clinical practice;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;cognitive function;Collaborations;Colorectal Surgery;Communities;Core Facility;County;Cystoscopy;Data Analyses;Data Coordinating Center;Dedications;Defecography;design;Diagnostic;Disease;economic cost;electronic health system;Electronics;Environment;Epigenetic Process;Evaluation;evidence base;Evidence based treatment;experience;Faculty;feasibility research;Fecal Incontinence;Fellowship;follow-up;Frequencies;Gastroenterology;Goals;Health;Health care facility;High Prevalence;improved;Infrastructure;Injections;innovation;Institution;Interdisciplinary Study;Laboratory Research;Latina;Leadership;Magnetic Resonance Imaging;medical schools;Methodology;Methods;microbiome research;micturition urgency;Multicenter Trials;multidisciplinary;Operative Surgical Procedures;Overactive Bladder;Participant;participant retention;patient population;Patient Recruitments;patient retention;Patients;Pattern;Peer Review;Pelvic Floor Disorders;pelvic organ prolapse;Pelvis;Physical therapy;Population;Population Heterogeneity;predictive modeling;Prevention;Procedures;Productivity;Professional Organizations;programs;Protocols documentation;Quality of life;Radiology Specialty;randomized, clinical trials;Reapplication;Recording of previous events;recruit;Reporting;Research;Research Design;Research Personnel;research study;Resources;Review Literature;Rural Community;Site;statistics;Structure of tibial nerve;suburban communities;success;systems research;Testing;Training;Translational Research;Transportation;trial design;ultrasound;Underrepresented Minority;United States;Urinary Incontinence;Urodynamics;Urology;Woman;Work

PROJECT_TITLE: Duke University Medical Center (DUMC) Pelvic Floor Disorders Network (PFDN) Clinical Site


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative This project investigates the basic mechanisms of how lipids are stored and released in tissues that are important for metabolic health. The processes of lipid synthesis and mobilization involve the assembly and interactions of protein complexes on the surface of specific intracellular organelles. This work will determine the composition of these protein complexes in liver and fat tissue and examine their function in response to physiological and pharmacological challenges, thereby clarifying how lipid levels in fat and liver are controlled and identifying novel points for therapeutic intervention.

PI_NAMEs: MOTTILLO, EMILIO  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Affinity;Animal Model;Binding;Binding Sites;Biological Assay;Cell Physiology;cell type;Cells;Chemicals;Complex;Coupled;Data;Diabetes Mellitus;Disease;Disease Progression;disease-causing mutation;Enzymes;Equilibrium;Esterification;Family member;Fatty acid glycerol esters;Fatty Acids;fatty liver disease;Fluorescence;Foundations;gain of function;Genetic;Genetic Models;genetic risk factor;genetic variant;Goals;Health;Hepatocyte;high resolution imaging;Homeostasis;Human;Hydrolase;Imaging Techniques;Immunoprecipitation;improved;Insulin Resistance;Isotopes;Knock-out;Label;Ligands;Lipase;lipid metabolism;lipidomics;Lipids;Lipolysis;Liver;Location;loss of function;Malignant Neoplasms;Maps;Metabolic;Metabolism;Mission;Modeling;Molecular;molecular imaging;Monitor;Muscle;mutant;Nature;novel;novel therapeutics;Obesity;Obesity associated disease;obesity treatment;Organelles;Pathologic;Pathway interactions;pharmacologic;Pharmacology;Phospholipase;Physiological;Play;Primary carcinoma of the liver cells;Process;protein complex;protein protein interaction;Proteins;Proteomics;Publishing;Regulation;Resolution;response;Risk Factors;Role;Surface;Techniques;Therapeutic Intervention;Tissues;tool;Tracer;trafficking;Transmission Electron Microscopy;Triglycerides;United States National Institutes of Health;Variant;Very low density lipoprotein;Work

PROJECT_TITLE: Molecular and cellular analysis of the ABHD5/PNPLA3 metabolon in lipid homeostasis

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Genetics

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE By revealing the mechanism through which the DNA replication machinery coordinates its functions at active and stalled replication forks, this study will provide new insight into how disruption of the replisome activity is linked to the perturbation of DNA replication fork integrity and genome instability. Gaining fundamental knowledge on how DNA replication process is kept in check against genotoxic stress will facilitate our effort to harness aberrant DNA replication problems of tumor cells for therapeutic intervention.

PI_NAMEs: KIM, HYUNGJIN  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Acute;Attention;Auxins;Binding;Biochemical;biological adaptation to stress;BRCA deficient;brca gene;Cell Line;Cells;Chromosome abnormality;Clinical;Collaborations;Complex;Data;Defect;Development;DNA;DNA biosynthesis;DNA Maintenance;DNA Repair;DNA Repair Enzymes;DNA replication fork;DNA-Directed DNA Polymerase;Event;Foundations;genetic approach;Genome;Genome Stability;Genomic Instability;Genotoxic Stress;helicase;Human;Human Cell Line;human disease;Human Engineering;Impairment;insight;Knowledge;Link;Maintenance;Malignant Neoplasms;Mediating;Molecular;Movement;Names;Nature;neoplastic cell;novel;Okazaki fragments;Pathologic;Pathway interactions;Poly Adenosine Diphosphate Ribose;Poly(ADP-ribose) Polymerases;Polymerase;Predisposition;preservation;prevent;Process;Proteins;Proteolysis;Regulation;replication stress;Replication-Associated Process;Role;scaffold;Scheme;Signal Transduction;Single-Stranded DNA;Source;Specific qualifier value;Stress;Stress Response Signaling;Structure;synthetic lethal interaction;System;targeted cancer therapy;targeted treatment;Therapeutic Intervention;treatment strategy;tumorigenesis;Ubiquitin;Work

PROJECT_TITLE: The interplay of TIMELESS and PARP1 in DNA replication fork stability

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Dietary Supplements;Eye Disease and Disorders of Vision;Neurosciences;Nutrition

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PUBLIC HEALTH NARRATIVE In humans, either prolonged dietary vitamin A deficiency (VAD) or inherited mutations in retinoid/visual cycle genes manifests in similar retinal degenerative phenotypes, eventually leading to vision loss and blindness. This study proposes to test the novel hypothesis that the retinol binding protein receptor 2 (RBPR2) facilitates and regulates dietary vitamin A transport and hence physiologically plays an important role in photoreceptor health and vision. At the completion of this project, a mechanistic understanding of RBPR2 function for ocular vitamin A homeostasis will help design strategies aimed at modulation of such eye-related ROL transporters for improving vision in humans with inherited retinal diseases.

PI_NAMEs: LOBO, GLENN P (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: absorption;Acceleration;Affect;Affinity;All-Trans-Retinol;Anabolism;Animal Model;Attenuated;Back;Binding;Binding Proteins;Binding Sites;Biochemistry;Biogenesis;Biological;Biological Assay;Blindness;Blood;Cell Culture Techniques;Cell Death;Cellular biology;Circulation;Co-Immunoprecipitations;cytotoxic;deprivation;design;dietary;Dietary Carotenoid;dietary excess;Disease;Docking;Ensure;extracellular;Extrahepatic;Eye;Fasting;gene product;Genes;Goals;Health;Hepatic Tissue;High Pressure Liquid Chromatography;Homeostasis;Human;human disease;Impairment;improved;In Vitro;in vivo;Inherited;innovation;Intestines;Kinetics;Knockout Mice;Knowledge;Ligands;Lipofuscin;Literature;Liver;Measures;Mediating;Mus;Mutation;novel;Ocular Pathology;old mice;Organ;Outcome;Patients;Peripheral;Phenotype;Photoreceptors;Physiological;Physiology;Play;prevent;Prevention;Process;Proteins;Public Health;RBP4 gene;receptor;Receptor-Interacting Serine/Threonine Protein Kinase 2;Recycling;Regulation;Reporting;Research;Retina;Retinal Degeneration;Retinal Diseases;Retinoids;retinol binding protein receptor;Role;Serum;Signal Transduction;Site-Directed Mutagenesis;Small Intestines;Spectrum Analysis;Structural Models;Supplementation;Surface Plasmon Resonance;System;Testing;Time;Tissues;Toxic effect;Tretinoin;uptake;Vision;visual cycle;Vitamin A;Vitamin A Deficiency;Zebrafish

PROJECT_TITLE: Physiological Role of the Vitamin A Transporter RBPR2 for Vision

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative While it is known that CD4 T cells protect against active tuberculosis, the M. tuberculosis antigens that are recognized by the CD4 T cells that provide protection remain to be identified. We identified a small set of M. tuberculosis antigens that are unusual for their evidence of evolutionary selection pressure and recognition by human and mouse CD4 T cells. In this proposed work, we will extend our discovery that human T cells that recognize these antigens exhibit distinct properties, and we will determine if CD4 T cells that recognize these antigens are associated with protection from active TB.

PI_NAMEs: ERNST, JOEL D. (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: active method;Adult;Aftercare;Antibodies;Antigen Presentation;Antigenic Variation;Antigens;Bar Codes;Biological Assay;CD4 Positive T Lymphocytes;Cell Physiology;Characteristics;comparative genomics;Cytoprotection;Defect;Development;Disease;disorder prevention;DNA;Elements;Epitopes;Exhibits;Frequencies;Gene Expression Profile;Genome;genomic locus;Goals;Human;human morbidity;human mortality;IL17 gene;Immune;Immune response;Immunity;Immunology;Individual;Infection;innovation;insight;Interferon Type II;Knowledge;M. tuberculosis genome;Memory;Modeling;Mus;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;neoplastic cell;new technology;next generation sequencing;novel;Open Reading Frames;Participant;pathogen;Peptide Library;Peptides;Phenotype;Phylogenetic Analysis;Population;pressure;prevent;Property;Proteome;receptor expression;response;Specificity;T cell response;T memory cell;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;transcription factor;transmission process;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;vaccine development;Work

PROJECT_TITLE: Functionally distinct human CD4 T cell responses to novel evolutionarily selected M. tuberculosis antigens

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE Understanding how healthy interactions between intestinal bacteria and the immune system are established and maintained is important for developing treatments for intestinal inflammation diseases like inflammatory bowel diseases and colorectal cancers. Akkermansia muciniphila is a human intestinal bacterium that produces anti-inflammatory factors in response to the diverse sugars that line the gut. This project will explore how Akkermansia senses and binds to sugars on the gut lining and on other gut bacteria and determine how these pathways shape intestinal health.

PI_NAMEs: SMITH, TIMOTHY JARROD (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Aeromonas;Anti-Inflammatory Agents;Bacteria;Bacterial Adhesins;Binding;Biochemical;Butyrates;Cell surface;Cells;Chronic;chronic inflammatory disease;Clinical;Colorectal Cancer;Communities;Cues;design;Disease;endoplasmic reticulum stress;Engineering;enteric infection;enteric pathogen;Environment;Epithelium;Evolution;Exhibits;experimental study;Fermentation;Genetic;Genetic Variation;Goals;gut bacteria;gut health;gut inflammation;gut microbes;gut microbiota;Health;Health Promotion;Home;Human;Immune response;Immune system;Immunologics;immunoregulation;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;innate immune pathways;insight;interest;intestinal epithelium;Intestines;Knowledge;knowledge translation;Laboratory Research;Learning;Mediating;member;Membrane;Metabolic Diseases;Microbe;microbial;microbial community;microbiome;microbiota;Modeling;Molecular;Mucins;Mucous body substance;Non-Insulin-Dependent Diabetes Mellitus;pathogen;Pathway interactions;Polysaccharides;Positioning Attribute;Probiotics;Process;Production;Property;Reagent;Regulation;Research;response;Role;Ruminococcus;Shapes;Signal Transduction;skills;Spatial Distribution;Structure;sugar;Surface;symbiont;Testing;Therapeutic;therapeutic development;therapy development;trait;Vesicle;Work;Zebrafish

PROJECT_TITLE: Understanding the molecular mechanisms of Akkermansia glycan-binding adhesins in shaping microbial communities and balancing intestinal inflammation in response to host signals

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Overall Component: Project Narrative Addressing a problem as daunting as persistent poverty and cancer requires approaches with a focus on changing the hazardous conditions in which people live, learn, work and play. The UPSTREAM Research Center, working with policy makers and community partners, will advance the science and practice of anti- poverty policies to prevent cancer in persistent poverty communities. Results from this work will lay the foundation for transformative approaches to address cancer prevention and control programs in the face of severe economic and social disadvantage through capacity building and sustainable partnerships with policymakers, state and local agencies and community partners.

PI_NAMEs: BONDY, MELISSA L.;CARVAJAL CARMONA, LUIS GUILLERMO;GRUSKY, DAVID B;HIATT, ROBERT A;REHKOPF, DAVID H (contact)

PROGRAM_OFFICER_NAME: HARDESTY, REBECCA ANNE

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Affect;Area;Behavior;Behavioral;California;Cancer Burden;Cancer Control;Cancer Etiology;Cancer health equity;cancer prevention;cancer risk;Cancer Science;career;career development;Catchment Area;Cause of Death;Cessation of life;Collaborations;Communities;community partners;Complex;Data Scientist;deprivation;Development;Diet;economic disparity;Environment;evidence base;Food;Foundations;Health;Health behavior;Health Services Accessibility;Health system;Healthcare;Housing;improved;Incidence;Income;Income Tax;Individual;Inequity;innovation;Intervention;Learning;Low income;Malignant Neoplasms;mathematical model;Mediating;member;Methodology;mortality;novel;Outcome;Personal Satisfaction;Persons;Physical activity;Pilot Projects;Play;Policies;Policy Developments;Policy Maker;poor communities;Population;Poverty;Poverty Areas;prevent;Process;programs;Research;research and development;Research Personnel;Research Project Grants;Resources;Risk Factors;San Francisco;Science;screening;social;Social Change;social determinants;social disparities;social health determinants;Social Sciences;Social Work;stress reduction;structural determinants;Supplementation;Testing;Training;Transportation;Universities;Wages;Work

PROJECT_TITLE: The Upstream Center: Income Interventions to Address the Fundamental Causes of Cancer Inequities


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: BONDY, MELISSA L. (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Applications Grants;Area;California;Cancer Control;Cancer Etiology;Cancer health equity;cancer prevention;Collaborations;Communication;Communities;community advisory board;community engaged research;community organizations;community partners;community partnership;Comprehensive Cancer Center;cost effectiveness;data resource;data sharing networks;Dedications;Department chair;Development;Ensure;Epidemiology;experience;Fostering;Future;Goals;health care delivery;Income;Inequality;Inequity;Information Dissemination;Information Systems;Infrastructure;Institution;Intervention;Knowledge;Leadership;lectures;Local Government;Malignant Neoplasms;meetings;member;Mentorship;Modeling;Monitor;Neighborhoods;Occupational activity of managing finances;operation;outreach;Performance;Pilot Projects;Play;Policies;population health;Positioning Attribute;Poverty;Poverty Areas;Productivity;professor;programs;Publications;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Role;San Francisco;Services;social media;sound;State Government;Subgroup;symposium;synergism;System;Training;Training Activity;Training Programs;United States National Institutes of Health;Universities;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Contemporary research on schizophrenia and other psychotic disorders reflects the general consensus that these are neurodevelopmental disorders. In parallel, in the past few decades, there has been a burgeoning body of research showing various environmental exposures during childhood to be associated with risk for psychosis. The proposed research will test the novel hypothesis that neighborhood residential instability (defined as the percentage of people in a neighborhood living in a different house in the past year) leads to psychosocial deprivation, which in turn contributes to reduction in corticolimbic gray matter volume, and ultimately increases risk for psychosis in at-risk youth.

PI_NAMEs: KU, BENSON  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Age;Air Pollution;American;Anterior;Area;Behavior;Brain;Brain region;Censuses;Characteristics;Child Abuse;Child Sexual Abuse;Childhood;cingulate cortex;Cities;clinical high risk for psychosis;Computer software;Consensus;County;Data;design;Development;Early Intervention;Elements;emotional neglect;Environmental Exposure;Environmental Impact;Environmental Risk Factor;Equation;Ethnic Origin;experience;Family history of;first episode psychosis;follow-up;Geography;Goals;gray matter;Health Resources;high risk population;Hippocampus;Human;Individual;Insula of Reil;Intervention;Interview;Investigation;Longitudinal Studies;low socioeconomic status;Magnetic Resonance Imaging;Measures;Mediating;Mediator;Mental disorders;Mental Health;Mentors;Methodology;Modeling;Neighborhoods;Neurobiology;Neurodevelopmental Disorder;novel;Outcome;Patients;peer;Persons;physical abuse;Population Density;Populations at Risk;Poverty;predictive test;Prevalence;prevent;Proxy;Psychoses;psychosis risk;psychosocial;Psychosocial Deprivation;Psychotic Disorders;Public Health;Publishing;Qualitative Methods;Race;Research;Research Design;Research Personnel;Risk;Risk Factors;rural area;Schizophrenia;sex;Sexual abuse;Site;social;Social isolation;social relationships;social stress;Subgroup;Testing;Thalamic structure;Training;Urbanicity;Work;Youth

PROJECT_TITLE: Impact of Neighborhood Characteristics on Conversion to Psychosis among Youth at Clinical High Risk for Psychosis

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: REHKOPF, DAVID H (contact)

PROJECT_TERMS: Address;Area;Behavioral;Cancer Burden;Cancer Etiology;cancer prevention;career;Categories;Centers for Population Health;Collaborations;Collection;Colorectal Cancer;Communities;community partners;County;Data;Data Collection;data curation;data dashboard;data resource;Dedications;Development;Disease;Doctor of Philosophy;Ensure;Environmental Risk Factor;experimental study;Funding;Health Sciences;Incidence;Income;Individual;Inequity;insight;interoperability;Intervention;intervention program;Latino;Leadership;Long-Term Effects;Malignant Neoplasms;mathematical model;Measures;Methodology;Methods;Mission;Modeling;Natural experiment;Pilot Projects;Play;poor communities;Population;Poverty Areas;prevent;Prevention;Prevention Research;Process;Productivity;Reproducibility;Research;Research Methodology;Research Personnel;Research Project Grants;Role;social factors;social health determinants;Surveys;synergism;Training;Universities;Vietnamese;Work

PROJECT_TITLE: Research and Methods Core


NIH_SPENDING_CATS: Autism;Biomedical Imaging;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Characterizing the contributions of high-dimensional biomarkers to susceptibility of neuropsychiatric disorders such as autism is critically important for advancing our understanding of their etiology and for developing new treatments. The fraction of variance explained (FVE) by a set of biomarkers is a measure of the total amount of information for an outcome contained in the predictor variables. In this project, we propose a general framework for FVE estimation, applicable to high-dimensional data including both GWAS and brain imaging settings, and apply these methods to the NIH-funded Adolescent Brain Cognitive Development (ABCD) Study, comprising longitudinal, multi-modal brain imaging, GWAS SNPs, and autism-related assessments for 11,875 participants aged 9-10 at baseline and continuing into early adulthood. 1

PI_NAMEs: SCHWARTZMAN, ARMIN  (contact);THOMPSON, WESLEY KURT

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Adolescent;aged;Alleles;Anatomy;autism spectrum disorder;Biological;Biological Markers;Brain;Brain imaging;Brain region;cognitive development;Complex;Computer software;Data;design;Diagnosis;Diffuse;Disease;emerging adult;Etiology;experience;Financial cost;Funding;Gene Expression;Genetic;Genome;genome wide association study;health assessment;Heritability;high dimensionality;Human Microbiome;interest;Laboratories;Maps;Measures;Mental disorders;Mental Health;Methodology;Methods;Modeling;multidimensional data;multimodality;Neuroanatomy;Neurobiology;neuroimaging;neuropsychiatric disorder;neuropsychiatry;novel;Outcome;Participant;Population;Predisposition;Prognosis;Proteomics;Regional Anatomy;Research;simulation;Single Nucleotide Polymorphism;Statistical Methods;statistics;Testing;theories;tool;United States National Institutes of Health;Validation;Variant;Work

PROJECT_TITLE: Estimating The Fraction of Variance Explained by Genetics and Neuroanatomy in Neuropsychiatric Conditions

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]