NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Neurosciences;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE  Spinal cord injury (SCI) disrupts sensory and motor pathways, resulting in motor impairments of the lower limb that negatively impact mobility. Mild breathing bouts of low oxygen (acute intermittent hypoxia, AIH) is a promising intervention that induces spinal plasticity, leading to improvements in both breathing and locomotion in rats and humans with SCI. However, the neural mechanisms that underlie functional improvements in humans with SCI are poorly understood. This proposal will quantify AIH induced changes in the synthesis of key neural substrates that support plasticity as well as examine predictive biomarkers to identify who optimally responds to AIH. Elucidating factors that facilitate and inhibit AIH responsiveness may significantly impact the lives of persons with paralysis.

PI_NAMEs: TAN, ANDREW QUESADA (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Acute;Address;Adjuvant;Ankle;Anterior;Biological Assay;Biological Markers;Biomechanics;Brain-Derived Neurotrophic Factor;Breathing;Chronic;Clinical;clinical translation;Corticospinal Tracts;Detection;Dose;Early Diagnosis;Enzyme-Linked Immunosorbent Assay;functional improvement;functional independence;functional loss;Goals;Hospitals;Human;Hypoxia;Immobilization;improved;indexing;Individual;individual response;insight;Intervention;Joints;Knowledge;Lateral;Locomotion;Lower Extremity;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Mediating;Mobility decline;Motor;motor impairment;Motor Pathways;motor recovery;Muscle;neural;neural circuit;neurochemistry;neuromechanism;Neuromodulator;Neuronal Plasticity;neurophysiology;neuroregulation;Oxygen;Paralysed;Participant;patient prognosis;Patients;Performance;Persons;potential biomarker;predictive marker;Rattus;Recovery;Recovery of Function;Rehabilitation therapy;Residual state;Resolution;respiratory;response;restoration;Rodent;Rodent Model;Sensory;Serotonin;Serum;service member;Spinal;Spinal cord damage;Spinal cord injury;Spinal Injuries;Structure-Activity Relationship;Testing;Training;Transcranial magnetic stimulation;Upper Extremity;Veterans;Walking;walking performance;walking rehabilitation;Work

PROJECT_TITLE: Identifying predictive biomarkers for acute intermittent hypoxia induced motor recovery in persons with incomplete spinal cord injury

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE This proposal will test the accuracy and reliability of autonomic measurements in bvFTD patients. Measurements will be collected both with established equipment and via at-home devices to assess the validity of the latter. Finally, autonomic measurements will be correlated to socioemotional dysfunction in patients.

PI_NAMEs: ELDAIEF, MARK CHRISTIAN (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Age;Arousal;Autonomic Dysfunction;Awareness;behavioral variant frontotemporal dementia;Biological Markers;Biometry;Blood Pressure;Cardiovascular system;Caregiver Burden;Caregivers;Caring;Clinical Trials;comparison control;Data;Development;Devices;Disease;Disinhibition;Dysautonomias;Emotional;emotional functioning;emotional symptom;Empathy;Environment;Equipment;Exhibits;Frontotemporal Dementia;Functional disorder;Functional impairment;functional MRI scan;Future;Gender;Genetic;Germination;Heart Rate;heart rate variability;Home;Home environment;Impaired cognition;Impairment;Impedance Cardiography;improved;Impulsivity;Laboratories;Link;Measurement;Measures;Monitor;Morbidity - disease rate;motor impairment;Nerve Degeneration;Neurobiology;new technology;novel;Outcome Measure;pain sensation;Patients;Perception;Performance;Phase;predictive marker;Pupil;Questionnaires;Recurrence;regional atrophy;Research;Sampling;Severities;Signal Transduction;Site;Skin Temperature;smart watch;social;Social Behavior;standard measure;Stimulus;Structure;Technology;Testing;Time;Visceral;wearable device;Work

PROJECT_TITLE: Characterizing autonomic impairments in Frontotemporal Dementia

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Opioids;Substance Misuse;Wound Healing and Care

ORG_CITY: MACON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: MERCER UNIVERSITY MACON

ORG_STATE: GA

PHR: PROJECT NARRATIVE NIDA recognizes the need for basic research on the pharmacology of xylazine to unravel the mechanisms that lead to its harmful effects associated with chronic co-intravenous (IV) administration of fentanyl, including necrotic skin lesions. This project will elucidate xylazine’s agonist affinity and its G protein-biased signaling properties at each of the adrenoceptor subtypes and will test the hypothesis that IV xylazine elicits necrotic skin lesions via a peripherally mediated α-adrenoceptor mechanism, laying the foundation for discovering the specific receptor and G protein mechanisms underlying IV xylazine’s toxic skin necrosis-inducing effects.

PI_NAMEs: CANAL, CLINTON E (contact);MONIRI, NADER H

PROGRAM_OFFICER_NAME: DRGONOVA, JANA

PROJECT_TERMS: Acute;Address;Adrenergic Agonists;Adrenergic Antagonists;Adrenergic Receptor;Adult;Adverse effects;Affinity;Agonist;Analgesics;Anesthetics;Animals;antagonist;antinociception;Appearance;Area;Arteries;Basic Science;Binding;Bioluminescence;Biopsy;Biosensor;Bradycardia;Chronic;Clonidine;constriction;Coupled;Cutaneous;Cyclic AMP;Disinhibition;Distal;Dose;Energy Transfer;Epinephrine;Etiology;Exhibits;Female;Fentanyl;Foundations;GTP-Binding Proteins;Hour;Human;Human Cloning;hypoperfusion;Hypotension;Hypoxia;in vivo;Individual;Injections;interest;Intravenous;intravenous administration;intravenous drug user;intravenous injection;Label;Lactic acid;Ligands;Link;link protein;Literature;male;Measures;Mediating;meter;Modeling;Molecular;Molecular Conformation;Muscle relaxants;Myosin Light Chain Kinase;National Institute of Drug Abuse;Necrosis;Necrosis Induction;Necrotic Lesion;novel;Opioid;opioid use disorder;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phospholipase C;Plasmids;Prazosin;pre-clinical;prevent;Property;Proteins;Radiolabeled;Randomized;Rattus;receptor;Receptor Signaling;Saline;Sampling;Sedation procedure;Signal Transduction;Signaling Protein;Site;Skin;skin lesion;skin ulcer;Smooth Muscle Myocytes;Sprague-Dawley Rats;Structure of umbilical artery;Technology;Testing;Transfection;treatment group;Umbilical vein;vascular bed;Vascular Smooth Muscle;vasoconstriction;Veins;Venous;Ventilatory Depression;Veterinary Medicine;Xylazine;Yohimbine

PROJECT_TITLE: Molecular pharmacology of xylazine at adrenoceptors: Relation to necrotic skin lesions associated with chronic intravenous administration

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative To form the brain circuits that will eventually carry out all neural functions, different types of neurons must precisely wire together. But the specific molecules that are responsible for forming connections between some cells and not others have not yet been identified due to a lack of scalable tools. In this proposal, I will uncover the molecular logic of cell type-specific connectivity by using efficient and state-of-the-art tools for screening the role of individual molecules, and visualizing both neuronal connectivity and cell type identity at scale.

PI_NAMEs: MOYA, MARIA VICTORIA (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Address;Adult;Advisory Committees;Anatomy;Animals;Applied Genetics;Area;Axon;Biological Assay;Boston;Brain;BRAIN initiative;Brain region;career;Cell Adhesion Molecules;Cell Communication;cell cortex;Cell Culture Techniques;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;connectome;CRISPR/Cas technology;Cues;design;Development;differential expression;experimental study;Fluorescent in Situ Hybridization;Foundations;Genes;Genetic;Goals;Guide RNA;In Situ;in vivo;Individual;innovation;Knock-out;Libraries;Logic;Maps;Measures;member;Mentors;Methodology;Methods;Molecular;Motor;motor control;Motor Cortex;Mus;Nerve Degeneration;nerve supply;neural circuit;neurodevelopment;Neurons;Neurophysiology - biologic function;Neurosciences;Optics;Pathway interactions;Pattern;Phase;Population;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;postnatal development;postsynaptic;presynaptic;programs;Proteins;Protocols documentation;Reagent;Research;Resources;response;Role;role model;Scientist;screening;Screening procedure;single cell sequencing;Specific qualifier value;Specificity;Stereotyping;Synapses;Technology;Testing;Thalamic structure;Time;Tissues;tool;Training;transcriptomics;Universities;Validation;Viral;Visualization;Work

PROJECT_TITLE: Uncovering the Molecular Determinants of Cell Type-Specific Connectivity

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (03)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: GALVESTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: Rift Valley fever virus causes an endemic disease in humans and livestock in sub-Saharan Africa, and there is serious concern about the possible introduction of this virus into North America. This research program seeks to clarify the fundamental mechanisms that control viral RNA packaging in RVFV. Our study will provide vital information for the development of a new vaccine platform and a live-attenuated RVFV vaccine.

PI_NAMEs: MAKINO, SHINJI  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Africa;Africa South of the Sahara;Agriculture;Animals;Anti-viral Response;Attenuated;Attenuated Vaccines;Binding;Binding Sites;Biological;Bioterrorism;Bypass;Categories;Cells;cis acting element;Code;Country;Culicidae;Data;Development;Disease;Disease Outbreaks;DNA-Directed RNA Polymerase;Domestic Animals;Economics;Encephalitis;Endemic Diseases;Ensure;experimental study;expression vector;Genetic Transcription;Genome;genomic RNA;Glycoproteins;Goals;Human;improved;Infection;Innate Immune Response;insight;interferon antagonist;Interferon-beta;Interferons;Knowledge;Licensing;Life Cycle Stages;Livestock;Location;macula;Mediating;Medical;Messenger RNA;Modeling;Molecular;Movement;National Institute of Allergy and Infectious Disease;North America;novel;novel strategies;novel vaccines;Orthobunyavirus;particle;pathogen;pathogenic virus;Patients;Population;pressure;Production;programs;Property;Proteins;Public Health;rational design;Reagent;Research;Retina;Rift Valley fever virus;RNA;RNA replication;RNA Viruses;RNA-Directed RNA Polymerase;Ruminants;Safety;Signal Transduction;Testing;Trans-Activators;transmission process;Untranslated RNA;vaccine platform;vaccine safety;Vaccines;Viral;Viral Genome;Viral Hemorrhagic Fevers;Viral Packaging;Viral Pathogenesis;viral RNA;Virion;Virus;Virus Diseases;virus envelope;Virus Replication;Visual impairment

PROJECT_TITLE: Modulation of viral genome packaging in Rift Valley fever virus

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Mental Health;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Women's Health Research

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: REALIST WOMEN STUDY The research project aims to address the higher cardiovascular disease (CVD) risk markers in Black women, inﬂuenced by factors such as insuﬃcient sleep and cumula�ve intersec�onal stress. To tackle this, the project proposes u�lizing innova�ve and accessible virtual reality (VR) technology for stress reduc�on and resilience s�mula�on, with a speciﬁc focus on Black women in South Florida. The ul�mate goal is to provide training in culturally tailored interven�ons for the researcher to address the unique stress-related health challenges faced by Black women, including cardiovascular issues, poor sleep, and psychological resilience.

PI_NAMEs: BLANC, JUDITE  (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: 20 year old;actigraphy;Address;Adherence;aged;American Heart Association;Area;arm;Back;Behavior Therapy;Behavioral;behavioral health;biobehavior;biological adaptation to stress;black women;Blood Pressure;blood pressure control;blood pressure reduction;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Caregiver Burden;Client satisfaction;Clinical Trials;Cognitive;Communities;comparison control;Competence;Complex;Control Groups;coping;Creativeness;Data;Diet;digital health;digital solutions;Distress;dosage;Ecological momentary assessment;Economics;Ensure;experience;Exposure to;Face;Family;Feedback;Florida;Focus Groups;follow-up;Gender;Goals;Health;Health Benefit;high risk;Hour;Hypertension;hypertensive;improved;Individual;innovation;Intervention;Interview;Life Style;Literature;Lived experience;marginalized population;Medicine;Mental Health;Mentored Research Scientist Development Award;Methods;mHealth;mindfulness;Minority;Morbidity - disease rate;mortality;novel;Outcome;Pamphlets;Participant;Partner in relationship;Persons;pilot test;poor sleep;portability;programs;promote resilience;psychologic;psychological trauma;Psychophysiologic Disorders;Race;randomized, clinical trials;Randomized, Controlled Trials;Reporting;Research;Research Design;Research Personnel;Research Project Grants;resilience;resilience scale;Risk;Risk Marker;Role;Sex Discrimination;skills;Sleep;Sleep Deprivation;Sleep Disorders;sleep health;sleep quality;statistics;Stress;stress management;stress reduction;stress resilience;stressor;success;Technology;Therapeutic;Time;Training;Trauma Research;virtual reality;virtual reality exposure;virtual reality intervention;White Women;Women's study

PROJECT_TITLE: Virtual Reality Intervention for Stress, Resilience, and Blood Pressure Management in Black Women

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-A (M1)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Pediatric;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative. Rates of cannabis use and disorders are high among young adults experiencing psychosis. Research indicates that continued cannabis use among this population is associated with a range of deleterious outcomes including decreased mental health engagement and medication management, increased rates of hospitalization, relapse and positive and negative psychotic symptoms. Given there are no identified evidence-based interventions to serve cannabis using young adults with psychosis, early intervention efforts with this population becomes an important public health objective.

PI_NAMEs: WALKER, DENISE D (contact)

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Abstinence;Active Listening;Address;Adherence;Aftercare;Age;Agreement;Ally;Antipsychotic Agents;arm;Cannabis;Caregiver Burden;Caregivers;Child;Client;Communication;Communities;Conflict (Psychology);Coordinated Specialty Care;Country;Creativeness;Data;Development;Disease;Dose;Dropout;DSM-V;Early Intervention;Education;Educational Intervention;Educational process of instructing;effective intervention;Effectiveness;Elements;Enrollment;Evidence based intervention;Evidence based practice;experience;Expressed Emotion;Family;Family member;Feedback;Feeling;Feeling hopeless;fighting;first episode psychosis;Focus Groups;follow-up;functional outcomes;Future;Glean;Goals;hospital readmission;hospitalization rates;Hour;improved;Individual;Influentials;insight;interpersonal conflict;Intervention;Interview;Knowledge;loved ones;marijuana legalization;marijuana use;marijuana use disorder;Medical;Medication Management;meetings;Mental Health;Modeling;Motivation;motivational enhancement therapy;Outcome;Participant;Patients;Pharmaceutical Preparations;Phase;pilot test;pilot trial;Population;post intervention;Process;Professional counselor;psychoeducation;Psychological reinforcement;Psychoses;psychotic;Psychotic Disorders;psychotic symptoms;Public Health;Randomized;randomized trial;Recovery;Recreation;recruit;Relapse;Reporting;Research;Risk;satisfaction;schizophrenia spectrum disorder;Self Efficacy;skills;Specific qualifier value;substance use;Substance Use Disorder;Suggestion;Symptoms;Testing;therapy development;Time;tool;Training;treatment as usual;Treatment Efficacy;Work;young adult

PROJECT_TITLE: Talking about Cannabis: Developing an Intervention for Family Members of Young Adults with FEP to Support Reduced Cannabis Use

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Sleep Research

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE Individuals who have insomnia with short sleep duration (ISS) differ from individuals who have insomnia with normal sleep duration (INS) in terms of health risks and treatment response. This study will examine whether patients with ISS and INS demonstrate a differential response to two common insomnia treatments, cognitive- behavioral treatment of insomnia (CBT-I) and trazodone. Our findings could lead to evidence-based treatment guidelines that help clinicians more effectively match treatments to insomnia patients and reduce associated health problems.

PI_NAMEs: BUYSSE, DANIEL J.;FERNANDEZ-MENDOZA, JULIO ;MORIN, CHARLES M.;SMITH, ELIZABETH DEVON;TAYLOR COUSAR, JENNIFER LYNN;VGONTZAS, ALEXANDROS N (contact)

PROGRAM_OFFICER_NAME: BROWN, MARISHKA

PROJECT_TERMS: actigraphy;Adult;Age;base;blind;Blood Pressure;blood pressure elevation;blood pressure reduction;cardiovascular disorder risk;Cardiovascular system;Characteristics;Classification;Clinical;clinical phenotype;clinical practice;Clinical Trials;Cognitive Therapy;cohort;Cohort Studies;Collaborations;comparative efficacy;Data;Decision Making;diaries;Disease;Disease remission;Double-Blind Method;Down-Regulation;Drug Prescriptions;efficacy evaluation;Evidence based treatment;Functional disorder;Funding;Genetic;Goals;Guidelines;Health;Health Care Costs;Home Blood Pressure Monitoring;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Impairment;improved;indexing;Individual;Knowledge;Measures;Mediating;Mental Health;Metabolic;Occupational Health;off-label use;Outcome;Participant;Patient Self-Report;Patients;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;Placebo Control;Placebos;Polysomnography;precision medicine;predicting response;primary outcome;Quebec;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Recommendation;Recording of previous events;Research Personnel;response;Risk;Salivary;Sampling;secondary outcome;Severities;sex;Side;side effect;Site;Sleep;Sleeplessness;Symptoms;Testing;Time;Trazodone;treatment effect;treatment guidelines;treatment response;trial design;United States National Institutes of Health;Validity and Reliability

PROJECT_TITLE: 1/2 Cognitive Behavioral Therapy and Trazodone Effects on Sleep and Blood Pressure in Insomnia Phenotypes Based on Objective Sleep Duration: A Sequential Cohort/Randomized Controlled Trial


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health

ORG_CITY: TALLAHASSEE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: Project Narrative The purpose of this project is to (1) systematically build the Settlement Abandonment Database, a comprehensive database of population counts for settlements both occupied and abandoned between 1890 and 2020 and (2) to leverage this new database with individuals in the Social Security Administration’s Death File matched to the 1940 Census to estimate the causal effect of settlement abandonment on human longevity. This project will build a new, comprehensive database of the life course of places in the US and leverage NIA- funded datasets within a causal design. The project will directly inform the long-term health consequences of ongoing federal policy concerning managed retreat, a form of managed, settlement abandonment.

PI_NAMEs: HAUER, MATHEW  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Acute;American;Area;Case Study;Censuses;Cessation of life;Cicatrix;Cities;Climate;climate change;Cognitive;Communities;Data;data resource;Data Set;Databases;design;Disadvantaged;Disparity population;Droughts;Dust;Economics;Ensure;Environment;environmental change;Event;evidence base;experience;Exposure to;federal policy;Florida;Funding;Health;health disparity;high risk;Human;Hurricane;improved;Individual;insight;Lead;Left;Life Cycle Stages;life span;Link;Longevity;Longitudinal Studies;Mental disorders;Migrant;migration;mortality;older adult;Outcome;Personal Satisfaction;Persons;Policies;poor health outcome;Population Database;Post-Traumatic Stress Disorders;Premature Mortality;pressure;Process;psychologic;Public Health;Quality of life;Race;racism;Research;Resources;Risk;Running;Sea;Shock;Social Change;Stressful Event;Terrorism;Testing;Time;Translating;United States;United States National Institutes of Health;United States Social Security Administration;Work

PROJECT_TITLE: Abandoned Settlements, Abandoned Health

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Muscle stem cells (MuSCs) have cellular projections that are hypothesized to be morphologically dynamic at quiescence, providing a surveillance function for muscle damage. MuSC niche factors which promote projection outgrowth are further hypothesized to promote quiescence but such factors are largely unknown. We have developed an ex vivo, live imaging assay to identify netrin-1 as a candidate factor of this type and propose research that will test its role in MuSC quiescence and the quiescence-activation transition in response to injury.

PI_NAMEs: KRAUSS, ROBERT S. (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Adult;Axon;Biological Assay;Cell Cycle;Cell Cycle Arrest;cell type;Cellular Morphology;Chemotactic Factors;Cues;Environment;Equilibrium;Event;Excision;Exploratory/Developmental Grant;Future;Genetic;high reward;high risk;Homeostasis;Image;Immunofluorescence Immunologic;in vivo;in vivo evaluation;injured;Injury;Lead;Maintenance;member;Morphology;Muscle;Muscle function;muscle progenitor cell;Mutant Strains Mice;Myoblasts;neogenin;netrin receptor;novel strategies;NTN1 gene;Preparation;Process;Proliferating;Property;Recombinants;regeneration following injury;Regulation;repaired;Research;response;response to injury;rho;rho GTP-Binding Proteins;Role;sensor;Series;Signal Transduction;Skeletal Muscle;Source;stem cell niche;Techniques;Testing;Tissues;Visualization;Work

PROJECT_TITLE: Regulation of Muscle Stem Cells by Netrin Signaling

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Prevention

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: The aging of the eyes is a phenomenon that many of us take as a given as we age, but indicators of mitochondrial function and genetics may provide a way to distinguish between individuals along the continuum from normal age-related vision changes to overt pathology. Mitochondrial damage is a major contributor to age-related diseases through cell apoptosis, dysregulated energy production, and inflammation, and is increasingly thought to be an important indicator of systemic aging. This project will evaluate the value of mitochondrial function and genetics as a marker of the biological aging of the eyes and susceptibility to pathologic damage leading to disease.

PI_NAMEs: ABRAHAM, ALISON G (contact);SUN, JING

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: Adenosine Triphosphate;Adult;Affect;Age;age related;age related changes;age-related disease;Aging;aging biomarker;aging process;aging related;aging related disease;Apoptosis;base;Bioenergetics;Biological Markers;Blindness;Cardiovascular Diseases;Caring;Cataract;Categories;Cells;Chronic Disease;Chronic progressive external ophthalmoplegia;Chronology;Clinical;clinical development;Clinical Trials Cooperative Group;cognitive function;Collaborations;Communities;Contrast Sensitivity;Data;Deterioration;Development;Diabetes Mellitus;Diagnostic Imaging;Disease;Dry Eye Syndromes;Environmental Exposure;Etiology;Evolution;experience;Eye;Eye diseases;fall risk;Fostering;Genetic;Genetic Risk;Genetic Variation;genome sequencing;genome wide association study;Glaucoma;Haplogroup;Haplotypes;Health;heteroplasmy;high risk;high risk population;Human;human old age (65+);Hypertension;Impaired cognition;improved;Individual;Inflammation;Intervention;Knowledge;Life;Literature;loss of function;Macular degeneration;Measures;Mental Depression;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial dysfunction;mutant;Mutation;Nuclear;nutrition;ophthalmic examination;optic nerve disorder;Oxidative Phosphorylation;Oxidative Stress;Pathologic;Pathologic Processes;Pathology;Pathway interactions;Physical activity;Play;polygenic risk score;Predisposition;Process;Production;Publishing;Regulation;Research Personnel;Retinal Diseases;retinal nerve fiber layer;Risk;risk prediction model;Role;Sampling;screening;Signal Pathway;Smoking;statistics;Suspect Glaucomas;systemic inflammatory response;Thinness;Tissues;Uveitis;Vision;Vision Tests;Visual Acuity;Visual impairment;whole genome

PROJECT_TITLE: The Aging Eyes Study: mitochondrial dysfunction as a driver of age-related vision loss

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (02)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposal develops a new type of x-ray detector with an improved ability to distinguish small features (on the order of 100 µm) compared to the currently available devices. This novel technology will benefit many applications in radiology where very fine organ structures and medical instruments need to be examined – for example small lung airways, bone trabeculae, vascular stents, and brain electrodes. The validation studies in this project will focus on bone imaging to better assess trabecular changes due to osteoporosis and osteoarthritis.

PI_NAMEs: ZBIJEWSKI, WOJCIECH BARTOSZ (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: 3-Dimensional;Ablation;absorption;Adult;Angiography;atomic layer deposition;attenuation;Biocompatible Coated Materials;Blood Vessels;Body Size;bone;bone imaging;Brain;Breast;burden of illness;Clinical;clinical translation;comparative;cone-beam computed tomography;Coupled;Degenerative polyarthritis;density;Deposition;design;Detection;detector;Development;Devices;Diagnosis;Diameter;Dose;Electrodes;Electronics;experimental study;Film;Frequencies;Future;healthcare burden;Human;Image;improved;in vivo;innovation;instrument;Interventional radiology;Lasers;Lateral;Light;Lung;lung imaging;Measurement;Medical;meter;Modernization;Morphology;new technology;Noise;novel;Optics;Organ;Orthopedics;Osteoporosis;Otolaryngology;Output;Oxides;Patients;Performance;potential biomarker;Procedures;Process;prototype;Pulmonology;quantum;radiological imaging;Radiology Specialty;Resolution;Roentgen Rays;sensor;Signal Transduction;Silicon;Site;Staging;Stents;Structure;substantia spongiosa;Techniques;Technology;Thick;Thinness;ultra high resolution;Validation;validation studies;vapor;Visualization;Work;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: Pixelated scintillators for ultra-high resolution cone-beam CT

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Diabetes;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_DEPT: PEDIATRICS

PHR: PUBLIC HEALTH RELEVANCE STATEMENT It is well known and accepted that type 2 diabetes significantly increases a person’s risk for cognitive issues including Alzheimer’s Disease and its related dementias. However, very little is known about how to identify individual people with type 2 diabetes who are at the greatest risk of developing cognitive issues and dementia. This study seeks to identify unique proteins from blood where higher or lower levels may indicate greater risk for cognitive issues in people with type 2 diabetes. Identifying unique proteins in blood will help to inform new screening tests for cognitive issues and dementia in people with type 2 diabetes.

PI_NAMEs: SHAPIRO, ALLISON LIVIA BUTI (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: adjudication;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;apolipoprotein E-4;Automobile Driving;Biological Markers;biomarker discovery;biomarker identification;Blood;Blood Proteins;Cognitive;cognitive testing;Dementia;Development;Diabetes Mellitus;diabetes prevention program;Diagnosis;Disease;drug development;drug discovery;endothelial dysfunction;Genotype;Glial Fibrillary Acidic Protein;glucose metabolism;Goals;high risk;Human;Impaired cognition;Individual;Inflammation;insight;insulin signaling;Intervention;Light;Link;link protein;lipid metabolism;mild cognitive impairment;Molecular;Nested Case-Control Study;Neurodegenerative Disorders;neurofilament;neuropathology;new therapeutic target;Newly Diagnosed;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;observational cohort study;Oxidative Stress;Persons;Pilot Projects;Plasma;Plasma Proteins;pre-clinical;prevent;protein biomarkers;Proteins;Proteome;Proteomics;public health relevance;Risk;Risk Marker;risk mitigation;risk prediction;risk stratification;Sampling;screening;Syndrome;tau-1;Time;treatment strategy;Visit

PROJECT_TITLE: Proteomic markers of risk for cognitive impairment in people with type 2 diabetes

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: AMHERST

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE Although remote trial designs have emerged as an approach for enhancing clinical trial efficiency and inclusiveness, the evidence base regarding the benefits and limitations of remote trials is weak. The proposed translational science project, a collaboration among four CTSA hubs, will evaluate the impact of remote methods on trial efficiency (accrual) and quality (retention, treatment adherence, bio-specimen completion rates), across 3 different use cases (a larger, multi-site demonstration trial and two smaller, single-site dissemination projects) and will explore the specific impact on under-represented patient groups facing health inequities. The proposed work will be widely disseminated, providing a critical foundation for evidence-based disease- and treatment-agnostic best practices in clinical trial methodology.

PI_NAMEs: HAWK, LARRY W (contact);MAHONEY, MARTIN CHRISTOPHER

PROGRAM_OFFICER_NAME: LEYVA, FRANCISCO

PROJECT_TERMS: Address;Age;age difference;Characteristics;cigarette smoking;Clinic;Clinical;Clinical Trials;Collaborations;Communities;Consent;cost;Cost Analysis;COVID-19 pandemic;Data;Decentralization;depressive symptoms;design;Development;Disease;Education;Educational workshop;Eligibility Determination;eligible participant;Ensure;Equity;ethnic difference;Ethnic Origin;Evaluation;evidence base;experience;Expert Opinion;follow-up;forging;Foundations;Future;Goals;health disparity;health equity;health inequalities;Hybrids;improved;innovation;Institution;Intake;interest;Intervention;Interview;Knowledge;Link;Medical center;Mental Depression;Methodology;Methods;mhealth interventions;Modality;multi-site trial;Naloxone;National Center for Advancing Translational Sciences;Newsletter;novel;opioid overdose;Outcome;overdose education;overdose prevention;Participant;patient screening;Patients;Persons;Pharmacotherapy;Phase;Press Releases;program dissemination;Public Health;Publications;Race;racial difference;Randomized;Randomized, Controlled Trials;recruit;remote assessment;remote therapy;Reporting;retention rate;Role;Savings;Series;Site;smoking cessation;social health determinants;Subgroup;symposium;Technology;Testing;therapy development;Translational Research;Travel;treatment adherence;treatment comparison;trial design;Uncontrolled Study;Underrepresented Populations;virtual;Visit;web site;webinar;Work

PROJECT_TITLE: Improving Efficiency, Quality, and Equity: Randomized Controlled Evaluations of Remote vs. In-Person Clinical Trial Methods

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-4 (02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Data Science;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE The “Clinical High Risk” (CHR) for psychosis syndrome in young people represents an opportune window for early intervention to prevent the onset of psychosis and other disorders, and to forestall disability; however, clinical heterogeneity and the paucity of biomarkers have hampered the development of effective intervention. To address these challenges, working with NIMH and key stakeholders, we will leverage our experience in the current observational study, the Accelerated Medicines Partnership® Schizophrenia (AMP® SCZ) Project, to validate potential drug development tools including biomarkers, digital measures, clinical outcome measures and predictive algorithms to refine and adapt these tools in the proposed clinical trial data processing, analysis, and coordination center (CT-DPACC), to support the Clinical Trial Network in a 12-16 week Proof of Principle trial(s) that will utilize a phase 2 ready compound.

PI_NAMEs: BOUIX, SYLVAIN ;KAHN, RENE S.;PASTERNAK, OFER ;SHENTON, MARTHA E. (contact)

PROGRAM_OFFICER_NAME: GARCIA, SUZANNE TYDLACKA

PROJECT_TERMS: Accelerated Phase;Acceleration;Address;Adverse event;Algorithms;Antipsychotic Agents;Attenuated;attenuated psychosis syndrome;Award;Big Data;Bioinformatics;Biological;Biological Markers;biomarker validation;Biometry;Brain;Clinical;Clinical Data;clinical heterogeneity;clinical high risk for psychosis;clinical outcome measures;Clinical Treatment;Clinical Trials;Clinical Trials Network;Cognition;Cognitive;cognitive testing;Communication;Communities;Community Outreach;computerized data processing;critical period;Custom;Data;data access;Data Analyses;data archive;Data Collection;data infrastructure;data management;data sharing;data standards;demographics;design;Development;Diagnosis;digital;digital measure;digital phenotyping;disability;Disease;drug development;Dyslipidemias;Early Intervention;effective intervention;Event;experience;Feeling suicidal;first episode psychosis;functional decline;Future;Genetic Predisposition to Disease;Glucose;Goals;hedonic;high risk;high risk population;improved;informatics infrastructure;Investigation;Investigational Drugs;Leadership;Liquid substance;Machine Learning;magnetic resonance imaging/electroencephalography;Measures;Medicine;meetings;Monitor;Moods;Morbidity - disease rate;Motivation;Multi-Institutional Clinical Trial;multidisciplinary;National Institute of Mental Health;Observational Study;operation;organizational structure;Outcome;outcome prediction;Participant;Perception;Persons;Pharmaceutical Preparations;Pharmacodynamics;Phase;predict clinical outcome;prediction algorithm;prevent;Procedures;Process;Protocols documentation;Psychoses;psychosis risk;Psychotic Disorders;psychotic symptoms;quality assurance;recruit;Reporting;Research;research clinical testing;Research Contracts;Research Design;Research Personnel;Resources;response;retention rate;Risk;Safety;Sampling;Schizophrenia;side effect;Signal Transduction;Site;Social Functioning;Source;Speech;Stratification;Structure;Subgroup;success;suicidal behavior;Symptoms;Syndrome;Tardive Dyskinesia;Testing;Thinking;Time;tool;tool development;Training;treatment effect;treatment response;United States;Validation;web site;Weight Gain

PROJECT_TITLE: Clinical Trial Data Processing, Analysis, and Coordination Center (CT-DPACC) for Accelerating Medicines Partnership Schizophrenia (AMP SCZ) Project

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-S (04)]


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Our research team has a unique opportunity to assess the impact of a transformative neighborhood level sanitation improvement intervention – the World Bank-funded Mozambique Urban Sanitation Project – construction on which will be completed in the city of Quelimane, Mozambique by December 2026. The goal of this study is to analyze previously collected baseline data and samples that will serve as critical preliminary data to enable a future evaluation of how the neighborhood wide sanitation improvements impact environmental contamination and acute and long-term child health outcomes. We will analyze current associations between living conditions, exposure risks, and infection rates of the population living in low-income neighborhoods in Quelimane; assess balance between intervention and comparison groups; and analyze samples using state-of- the-art molecular assays.

PI_NAMEs: CAPONE, DREW  (contact);FREEMAN, MATTHEW C;LEVY, KAREN

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: 5 year old;Achievement;Acute;Acute Disease;Anthropometry;Area;arm;Behavior;Biological;Biological Assay;Brazil;built environment;burden of illness;Child;Child Development;Child Health;Cholera;Chronic;Cities;Climate;climate change;Collection;Communities;comparison group;Controlled Study;Costs and Benefits;Data;Data Collection;Defecation;demographics;Development;Diarrhea;Disease;disease transmission;Drainage procedure;Enteral;enteric pathogen;Environment;Environmental Exposure;Environmental Impact;Environmental Pollution;Environmental sludge;Equilibrium;Evaluation;experience;Exposure to;extreme weather;Feces;field study;fly;Frequencies;Functional disorder;Funding;Future;Goals;Growth;Health;health assessment;Household;Impact evaluation;improved;Individual;Infection;infection rate;Infrastructure;Interdisciplinary Study;Intervention;Investments;Latrine;Low income;Maps;Marketing;Measures;Methods;microbial;Modeling;Molecular;Mozambique;Municipalities;Natural experiment;Neighborhoods;Outcome;Parasites;pathogen;Pathway interactions;Persons;Pilot Projects;Plants;Population;population based;Predisposition;Prevalence;Public Health;Randomized;Research;resilience;Reverse Transcription;Risk;Sampling;Sanitation;Schedule;Schools;Severities;Site;Soil;Specimen;stool sample;Surveys;System;Time;Toilet Facilities;urban setting;Urbanization;wasting;Water;Work;World Bank

PROJECT_TITLE: Determining the health and environmental impacts of a neighborhood-wide sanitation intervention in Quelimane, Mozambique

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The purpose of this project is to learn whether an intervention that provides households with home-delivered healthy, frozen meals tailored to illness-related conditions for 12 weeks during a child’s treatment for serious illness is feasible and acceptable to the child and the parent mainly responsible for the child’s care.

PI_NAMEs: SANTACROCE, SHEILA JUDGE (contact)

PROGRAM_OFFICER_NAME: LONG, SYLVIA ELISABETH

PROJECT_TERMS: acceptability and feasibility;active method;Address;Adult;Affect;Age;age acceleration;arm;Businesses;Cancer Survivor;cancer therapy;Cardiovascular system;care delivery;Caregivers;caregiving;Caring;chemotherapy;Child;Child Care;Child health care;Childhood;clinical care;Clinical Sciences;clinically relevant;Collaborations;Complex;Conscious;coping;cost;cost effectiveness;daily functioning;Data;delivered meals;Diet Habits;Dietary Intervention;Disparity;Drug Prescriptions;effectiveness study;efficacy trial;Equity;experience;Feasibility Studies;Feedback;Financial Hardship;Flavoring;Food;food insecurity;Freezing;Funding;Future;Gifts;Goals;Health;health care cost/financing;health care settings;health disparity;health equity;Health Food;health inequalities;Health Insurance;Health Promotion;Healthcare;High-Risk Cancer;Home;Household;Immunotherapy;improved;Individual;Inequity;infection risk;Insulin;Intervention;Learning;Legal;lens;Life;Link;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical;Medicine;meetings;Methods;Modeling;National Institute of Nursing Research;National Institute on Minority Health and Health Disparities;nutrition;Nutritional;Outcome;outcome disparities;Outpatients;Parents;Patients;Policies;Population;Populations at Risk;Poverty;Price;primary caregiver;Process;Protocols documentation;Quality of life;Randomized;Regimen;Research;Risk;Role;Security;Siblings;Signal Transduction;social;Strategic Planning;Stretching;survivorship;Symptoms;Taste Perception;Taxes;Time;treatment response;Uncertainty;United States Department of Agriculture;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Feasibility of Medically Tailored Meals for Pediatric Populations at Risk for Disparities in Serious Illness Outcomes due to Inequities in Food-Related Social Drivers of Health

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: ROCHESTER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Our proposal investigates the concept of the human spleen as an evolving and complex archive of antigen- specific memory B cells (MBCs), rather than simply an MBC reservoir. Findings supporting this idea would suggest that the spleen plays an unappreciated role in MBC maintenance and is potentially a key determinant of an individual’s MBC response potential. Results could be important for a full appreciation of the consequences of splenectomy, disease states associated with hyposplenism, B cell depletion therapies, and splenic changes associated with infections.

PI_NAMEs: SANGSTER, MARK Y (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Adult;Affinity;Age;Antibodies;Antibody Formation;Antibody Response;Antigens;Archives;B cell therapy;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;Back;Binding;Biological Assay;Blood;Callback;Cell Count;Cell Maintenance;Cells;Cellular Immunity;Cellularity;Childhood;Chronology;Circulation;Clone Cells;Collaborations;Collection;Complement;Complex;Cross Reactions;cross reactivity;Data Analyses;Destinations;Disease;Epitopes;Evaluation;Exhibits;experimental study;Exposure to;Family;Flow Cytometry;flu;fluorophore;Frequencies;Genes;Heavy-Chain Immunoglobulins;Hemagglutinin;high throughput screening;Homeostasis;Human;Immune;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;Immunoglobulin-Secreting Cells;Immunophenotyping;imprint;In Vitro;Incidence;indexing;Individual;Infection;Influenza;Influenza A virus;Influenza Hemagglutinin;influenza infection;influenza virus strain;influenza virus vaccine;Investigation;Length;Life;Linear Models;Literature;Longevity;Lymphoid Tissue;Maps;Measurement;Measures;Medicine;Memory B-Lymphocyte;Methods;Modeling;Mutation;New York;novel;Operative Surgical Procedures;pathogen;Pattern;Phenotype;Play;Population;response;Role;Sampling;Seasons;Signal Transduction;single cell analysis;Site;Sorting;Spleen;Splenectomy;Splenocyte;Surface;Testing;timeline;trafficking;Trauma;Trees;unsupervised clustering;Vaccination;Variant;Viral;Viral Antigens;Virus

PROJECT_TITLE: Investigating the human spleen as an archive of memory B cells reactive to the influenza virus hemagglutinin

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer

ORG_CITY: STRATFORD

ORG_NAME: ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED

ORG_STATE: NJ

PHR: Project narrative This research project aims to investigate the impact of oxidative stress on RNA modifications in cancer, specifically focusing on lung cancer cells. By studying these oxidative modifications and the proteins interacting with them, the project seeks to enhance our understanding of deregulated gene expression in cancer cells, potentially leading to new insights into cancer development and treatment.

PI_NAMEs: PESTOV, DIMITRI G (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Address;Affect;antioxidant enzyme;Area;Binding Proteins;Biochemical;Cancer Biology;cancer cell;Cancer cell line;Cell Compartmentation;Cell Nucleus;Cells;Chemicals;Client;Cytoplasm;Development;Disease;Exhibits;Family;Gene Expression;Gene Expression Alteration;Gene Expression Regulation;gene function;Heterogeneous-Nuclear Ribonucleoproteins;innovation;insight;Knowledge;KRAS oncogenesis;KRAS2 gene;KRASG12D;lung cancer cell;Malignant Neoplasms;Maps;Messenger RNA;Metabolic;Methods;Modification;Molecular;next generation sequencing;Non-Small-Cell Lung Carcinoma;nucleobase;Outcome;Outcome Study;oxidation;Oxidation-Reduction;Oxidative Stress;Pathogenesis;Pathologic;Pattern;Physiological;Play;Proteins;RAS driven cancer;RAS genes;Reader;Regulation;Research;Research Priority;Research Project Grants;Resolution;response;RNA;RNA Splicing;Role;superoxide dismutase 1;System;Techniques;Technology;Testing;Therapeutic Intervention;transcriptome;United States National Institutes of Health

PROJECT_TITLE: RNA oxidation in RAS-driven cancer

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE  This project responds to the research need of more rigorous evaluation of unmeasured confounding in epidemiological analyses of environmental mixtures. We will develop advanced models for causal inference based on Bayesian probabilistic sensitivity analyses and negative control exposures approaches along with computationally efficient and user-friendly R packages to evaluate the impact of unmeasured confounding when causal inferences on multiple continuous exposures are sought. The proposed approaches will enable causal inference on joint exposure effects to inform policy for environmental exposures and child development.

PI_NAMEs: VALERI, LINDA  (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Accounting;Adopted;Affect;Arsenic;Bangladesh;Bangladeshi;Bayesian Method;Biology;Birth;Birth length;Characteristics;Chemicals;Child;Child Development;Clinical;Cognition;cohort;Cohort Studies;community engagement;Complex;cooking;data access;Development;dimension reduction;Environmental Epidemiology;Environmental Exposure;Environmental Policy;Epidemiology;epidemiology study;Etiology;Evaluation;Exposure to;Face;Funding;Genetic;Genetic Complementation Test;Goals;Grant;Health;high dimensionality;Human;indexing;Individual;Infant;interactive visualization;interest;Intervention;Investigation;Joints;Lead;lead exposure;Machine Learning;Manganese;Metal exposure;Metals;Methodology;Methods;micronutrient deficiency;Modeling;Mothers;National Institute of Environmental Health Sciences;neurodevelopment;novel;Outcome;Policies;policy recommendation;pollutant;Pollution;prenatal;programs;Recommendation;Reporting;Research;Research Personnel;Residual state;response;Science;Signal Transduction;software development;Source;Specific qualifier value;Statistical Methods;Structure;Time;Translating;translational study;Translations;Uncertainty;user friendly software;user-friendly;Work

PROJECT_TITLE: Machine Learning remedies to unmeasured confounding biases in environmental mixture studies

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Heart Disease;Palliative Care;Patient Safety

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narra�ve This project will develop and test a novel clinical decision support tool that encourages timely referral to palliative care for people hospitalized with heart failure. This clinical decision support intervention will deliver prognostic information and evidence-based decision support at the point of care. Thus, this research may lead to improved care-concordant and goal-directed care for people with heart failure.

PI_NAMEs: FEDER, SHELLI LEORE (contact)

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: Address;Advance Care Planning;Affect;American;American Heart Association;behavior change;Cardiology;care delivery;care outcomes;Caring;clinical decision support;Clinical Trials;cognitive load;college;Consolidated Framework for Implementation Research;Data;Decision Making;design;Development;Documentation;Effectiveness;effectiveness clinical trial;Electronic Health Record;end of life;Engineering;Evaluation;evidence base;Feedback;Focus Groups;Goals;Guidelines;health care availability;health care service utilization;Health Personnel;Health system;Heart failure;hospice environment;hospice utilization;hospital readmission;Hospitalization;Hospitals;Human;Hybrids;implementation strategy;improved;innovation;Intervention;Interview;iterative design;Length of Stay;Modality;Modeling;Morbidity - disease rate;mortality;mortality risk;multi-site trial;novel;Palliative Care;Patient Care;patient prognosis;Patient-Focused Outcomes;Patients;Performance;Persons;Pilot Projects;pilot test;pilot trial;point of care;Population;preference;primary outcome;Procedures;Process;Prognosis;prognostic;prototype;provider behavior;Quality of life;Randomized;Recommendation;Research;secondary outcome;Services;Site;Societies;Specialist;support tools;Surveys;Symptoms;Testing;theories;Time;tool;treatment as usual;Update;usability;user centered design

PROJECT_TITLE: Promoting Palliative Care for People with Heart Failure: The P3HF Pilot Study

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT (MA)]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Skin Cancer

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Immunotherapies have significantly improved melanoma treatment, but drug resistance has limited their therapeutic efficacy. Emerging evidence suggests a fundamental link between vascular abnormalities and immune evasion in the tumor microenvironment whereby vascular destabilization impairs the tumor infiltration of immune cells. In this project, we propose to study the vascular determinants of immune exclusion from the tumor core and the underlying mechanisms in melanoma.

PI_NAMEs: KIM, MINAH  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Address;Affect;Angiopoietin-2;Biological Markers;Biology;Blocking Antibodies;Blood Vessels;Cells;Cessation of life;Cytotoxic T-Lymphocytes;Development;Disease Progression;Drug resistance;Effectiveness;Effector Cell;Endothelial Cells;Exclusion;experience;Foundations;Human;imaging approach;Immune;Immune checkpoint inhibitor;Immune Evasion;Immunosuppression;Immunotherapy;Impairment;improved;Infiltration;Inflammation;insight;Link;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Melanoma;Melanoma patient;Methodology;Methods;Modeling;Molecular;multiple omics;Mus;neoplastic cell;novel;optical imaging;Pathway interactions;Patients;Pattern;Positioning Attribute;prevent;programs;Proteomics;Publishing;Receptor Protein-Tyrosine Kinases;Regulation;Research;Resistance;response;Signal Transduction;Signaling Molecule;Skin Cancer;success;T cell infiltration;T-Lymphocyte;TEK gene;therapeutic target;TIE-2 Receptor;Tissues;transcriptome sequencing;transcriptomics;Treatment Efficacy;tumor;tumor microenvironment;tumor progression;Tumor-infiltrating immune cells;vascular abnormality;Vascular remodeling;Work

PROJECT_TITLE: Unraveling Vascular Mediated Immune Exclusion in Melanoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-S (M2)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: RICHMOND

ORG_DEPT: GENETICS

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: There is a pressing need to make the biomedical research enterprise in the US more inclusive. With our dedicated team of teaching and research mentors, comprehensive and rigorous career development regimen, and talented pool of postdoctoral scholars, VCU IRACDA is making significant contributions to this effort.

PI_NAMEs: BULLARD, DANIEL C (contact);RYAN, JOHN J

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Address;Biomedical Research;career;career development;Collaborations;Creativeness;design;Educational Curriculum;Educational process of instructing;Environment;Evaluation;experience;Face;Faculty;follow-up;Foundations;Future;Goals;Health Priorities;Historically Black Colleges and Universities;Institution;medical schools;member;Mentors;Methodology;pedagogy;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;programs;Qualifying;recruit;Research;Scientist;skills;Students;System;Training;trend;Universities;university student;Virginia

PROJECT_TITLE: Virginia Commonwealth University IRACDA

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-B (MS)]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Heart Disease;Heart Disease - Coronary Heart Disease;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative Since there is a lack of evidence for treatment in this population, this proposal will fill an unmet need in managing women with angina with nonobstructive coronary artery disease (ANOCA) and microvascular disease. Our proposal will significantly advance our understanding of SGLT2 inhibitors' potential benefits in coronary microvascular disease. Knowing SGLT2i's effect on inflammation pathways and markers of systemic Inflammation will allow for the discovery of a potential mechanism of SGLT2i's cardioprotective effects and allow us to design more targeted studies, such as those that assess the drug's impact on specific cytokines.

PI_NAMEs: RODRIGUEZ LOZANO, PATRICIA FIORELLA (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Advanced Glycosylation End Products;Aftercare;Animal Model;atherogenesis;Atherosclerosis;Attention;Attenuated;Biological Availability;Biological Process;Blood flow;Blood Vessels;calcification;Cardiac;Cardiac Output;cardioprotection;Cardiovascular system;Cause of Death;CCL2 gene;Cell Adhesion;Cellular Metabolic Process;Chronic Kidney Failure;Clinical;Clinical Trials;Communities;Complement Activation;Congestive Heart Failure;Coronary;Coronary Angiography;Coronary Arteriosclerosis;cytokine;Data;design;Diabetes Mellitus;Disease;Dyspnea;efficacy evaluation;efficacy testing;Endothelium;Energy Metabolism;Equipment and supply inventories;EuroQOL;Event;Fatty acid glycerol esters;Feasibility Studies;Functional disorder;functional status;Glucose;glycemic control;Heart Diseases;Heart failure;heart failure with reduced ejection fraction;High Prevalence;Hospitalization;IL6 gene;Immune response;improved;Individual;Inflammation;Inflammatory;inflammatory marker;inhibitor;inhibitor therapy;Innovative Therapy;Interleukin-1 beta;Investigation;Ischemia;Isoprostanes;Knowledge;Lesion;Magnetic Resonance;Measures;Medicine;men;Microvascular Dysfunction;Modeling;mortality;mouse model;Myocardial Infarction;Myocardial Ischemia;Myocardial perfusion;Nitric Oxide;Non-Insulin-Dependent Diabetes Mellitus;Outcome Assessment;Oxidative Stress;Participant;Pathway interactions;Patients;Pattern;Perfusion;persistent symptom;Pharmaceutical Preparations;Phenotype;Placebos;Plasma;Population;pre-clinical;Pre-Clinical Model;Process;prospective;Proteins;Quality of life;Questionnaires;randomized trial;Randomized, Controlled Trials;Recommendation;recruit;reduce symptoms;Regulation;Risk;sex;Sex Differences;Signal Transduction;Sodium;Stenosis;Stress;symporter;Symptom Burden;Symptoms;systemic inflammatory response;Tissues;trend;Vascular Endothelium;Woman;Women's mortality;women's treatment;young woman

PROJECT_TITLE: Innovative Therapy to Treat Women with Angina with Nonobstructive CAD (ANOCA) and Coronary Microvascular Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-A (M1)]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE People with malaria are more susceptible to invasive bacterial infections due to neutrophil dysfunction which can persist for weeks following malaria infection. This project aims to determine the signaling mechanism by which a secreted malaria virulence factor, HRPII, causes neutrophil dysfunction. The pathways identified can help guide the development of new therapies to restore neutrophil function and prevent this severe consequence of malaria infection.

PI_NAMEs: GOLDBERG, DANIEL E. (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acute;Affect;antagonist;Bacterial Infections;Binding;Biological Assay;Blood;Blood Circulation;Blood Vessels;Cancer cell line;Candidate Disease Gene;Cell Culture Techniques;Cell Line;Cell surface;cell type;Cells;Chemicals;Chemotaxis;Child;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;CRISPR/Cas technology;Defect;Development;dihydrorhodamine 123;Dimethyl Sulfoxide;Endocytosis;Endothelial Cells;Endothelium;Enzymes;Etiology;experimental study;Exposure to;Extravasation;Falciparum Malaria;Family;Flow Cytometry;follow-up;Functional disorder;G-Protein-Coupled Receptors;Genes;Genetic Transcription;genome-wide;Genomic Library;Goals;Half-Life;Heme;heme oxygenase-1;histidine-rich proteins;HL60;Hour;Human;human model;Immune response;Immune System Diseases;Immunofluorescence Immunologic;Impairment;Incubated;Infection;Inflammation;inhibitor;insight;Investigation;Knock-out;knockout gene;Malaria;malaria infection;Measures;Mediator;Modeling;Molecular;Molecular Target;mortality;mouse model;Mus;NADPH Oxidase;nanoparticle;neutralizing antibody;neutrophil;novel therapeutics;Oxygenases;Parasites;Pathway interactions;Patients;Persons;Pertussis Toxin;Phagocytosis;Plasma;Plasmodium falciparum;polypeptide;Predisposition;prevent;preventive intervention;Production;Proteins;Protoporphyrins;Reactive Oxygen Species;receptor;Reporting;Research;Respiratory Burst;response;Role;Salmonella;Salmonella infections;screening;Severities;Signal Pathway;Signal Transduction;Therapeutic;Time;TLR4 gene;transcriptome sequencing;transcriptomic profiling;transcriptomics;Transfection;Up-Regulation;Vascular Endothelial Cell;Virulence Factors;Work

PROJECT_TITLE: Mechanism of neutrophil dysfunction by Plasmodium falciparum secreted histidine-rich protein II

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (09)]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The core function of immunity is to distinguish self from non-self, yet in the process of sterile immunogenic cell death, our immune system recognizes our own dead cells as foreign. This process can thus lead to autoimmunity, though it can also be useful in cancer treatment if induced in the right time and place. This proposal seeks to apply breakthrough functional genomic technologies to interrogate the molecular basis of immunogenic cell death and potentiate new treatments in autoimmunity, cancer, and other diseases of the immune system.

PI_NAMEs: KAMBER, ROARKE ALEXANDER (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immune response;Adjuvant;Adjuvanticity;Advanced Development;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Antigens;Apoptotic;Autoantigens;Autoimmune Diseases;Autoimmunity;Binding;blocking factor;calreticulin;cancer cell;cancer immunotherapy;cancer therapy;Cell Death;Cell Death Induction;Cells;Cellular biology;Communicable Diseases;Complex;Consumption;Data;Decision Making;Dendritic Cells;design;Development;Disease;experience;functional genomics;Genes;Genetic;Genetic Screening;Health;Human;Immune;Immune response;Immune system;Immune System Diseases;Immunity;immunogenic;immunogenic cell death;immunogenicity;Immunologics;improved;Infection;insight;Investigation;Knowledge;Lead;Ligands;Link;Lysosomes;Macrophage;Malignant Neoplasms;Mediating;Methodology;Modernization;Molecular;Myeloid Cells;new technology;pathogen;Pathogen detection;pathogenic virus;Pathway interactions;Pattern;Pattern recognition receptor;Permeability;Phagocytes;Phagocytosis;Phagolysosome;Phagosomes;Play;Positioning Attribute;Postdoctoral Fellow;preservation;prevent;Process;Quantitative Genetics;Regulation;response;Retinal blind spot;Role;screening;Self Tolerance;Signal Pathway;Signal Transduction;Sterility;Stress;System;T-Cell Activation;Technology;Therapeutic;therapeutic target;therapy design;therapy development;Time;TLR4 gene;tool;tool development;tumor;uptake;Validation;Vision

PROJECT_TITLE: Deciphering the immunogenicity of cell death using systematic genetic tools

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 VSR-D (M1)]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Lung;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Project Narrative We have developed novel and innovative techniques for lung organoid cultures that more closely mimic the in vivo airway environment. The goal of the current proposal is to utilize these to study the effect of the extracellular matrix on normal airway basal stem cell homeostasis and how this is disrupted in chronic obstructive airways disease (COPD).

PI_NAMEs: REN, XI ;WEISS, DANIEL J (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Address;Affect;Airway Disease;airway epithelium;Alveolar;alveolar epithelium;Apical;Behavior;Biological Models;Blood Vessels;cell behavior;Cell Communication;Cell Differentiation process;cell growth;Cell Maintenance;Cell surface;Cell Therapy;cell type;Cells;Chronic Obstructive Airway Disease;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;Cystic Fibrosis;Data;Development;Disease;Environment;Epithelial Cells;Epithelium;Extracellular Matrix;GAG Gene;Gel;Genetic Transcription;Glycosaminoglycans;Goals;Homeostasis;Human;Hydrogels;idiopathic pulmonary fibrosis;in vitro Model;in vivo;Individual;Injury;injury and repair;innovation;insight;Iowa;Knowledge;Link;Lung;Lung Diseases;lung injury;lung repair;Maintenance;matrigel;Mucins;novel;novel therapeutics;Organoids;particle;Pathogenesis;Pathway interactions;Physical environment;Play;Population;Proliferating;Property;Proteins;Proteoglycan;Regulation;Role;self-renewal;Series;Signal Transduction;Source;spheroids;stem cell homeostasis;stem cells;Structure;Suspensions;System;Techniques;tool;Transplantation;Universities

PROJECT_TITLE: Extracellular Matrix Regulation of Airway Epithelial Homeostasis

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: Project Narrative The resolution of inflammation is a critical mechanism leading to the healing of damaged tissue and a restoration of homeostasis. Failure of resolution is now considered a primary driver of chronic inflammatory disease in many different tissues, yet we understand little about the regulation of resolution mechanisms. In this proposal we will examine the role of reverse transendothelial migration (rTEM) of neutrophils on resolution of Lyme arthritis.

PI_NAMEs: BROWN, CHARLES R. (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Anti-Inflammatory Agents;Antibiotic Therapy;Apoptosis;Arachidonate 15-Lipoxygenase;Arachidonate 5-Lipoxygenase;Arthralgia;Arthritis;Asthma;Atherosclerosis;Bacteria;Biochemical Pathway;Biological Models;Bone Marrow;Borrelia burgdorferi;Cells;Characteristics;chemokine;Chronic;chronic inflammatory disease;Complex;cyclooxygenase 1;cytokine;Data;Development;Dinoprostone;Disease;Eicosanoids;Endothelium;Excision;Experimental Models;Failure;Genetic;healing;Homeostasis;Immune;in vivo;in vivo Model;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Arthritis;Inflammatory Response;Invaded;joint inflammation;Joints;Kinetics;Knockout Mice;Knowledge;Leukotriene B4;Lipids;lipoxin A4;Lung;Lyme Arthritis;Lyme Disease;Macrophage;Mediating;Mediator;Metabolic Pathway;Microbe;microbial;microorganism;migration;mouse model;Mus;neutrophil;Neutrophil Infiltration;Non-Steroidal Anti-Inflammatory Agents;novel therapeutics;Order Spirochaetales;pathogenic bacteria;pathogenic microbe;Pathology;Pathway interactions;Patients;Pharmacological Treatment;Play;prevent;Process;Production;programs;Prostaglandin-Endoperoxide Synthase;Proteins;PTGS2 gene;recruit;Regulation;repaired;Reporting;Resolution;response;restoration;Risk;Role;Signal Transduction;Site;Sterility;Syndrome;Synovitis;Therapeutic;tick borne spirochete;tissue injury;Tissues;trafficking;Travel;Treatment Efficacy;Work;Zebrafish

PROJECT_TITLE: Mechanisms of Reverse Transendothelial Migration in Arthritis Resolution

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Autoimmune Disease;Psoriasis

ORG_CITY: SUNNYVALE

ORG_NAME: MOLECULAR MEDICINE RESEARCH INSTITUTE

PHR: Project Narrative  This proposal seeks to understand how fatty acid synthesis in immune cells or skin tissues contributes to the development of skin inflammation. We will elucidate the previously unidentified mechanism that is regulated by fatty acid synthesis in the development of inflammatory skin disease using a mouse model of psoriasis. The outcome of this study will guide us to develop novel targeted therapies for the treatment of inflammatory diseases.

PI_NAMEs: KANG, YOUNG JUN (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Active immunity;Affect;Anti-Inflammatory Agents;Applications Grants;Arthritis;Autoimmune Diseases;CD8-Positive T-Lymphocytes;Cell Physiology;Cell Reprogramming;cell type;Cells;Cellular Metabolic Process;Cerulenin;Colitis;Data;Development;Disease;Enzymes;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Fatty-acid synthase;Future;Gene Expression;Generations;Genes;Glycolysis;Host Defense;Imiquimod;Immune;immune activation;immune function;Immune response;Immunity;immunodeficiency;immunoregulation;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;inhibitor;insight;keratinocyte;Knowledge;liver inflammation;Macrophage;Membrane;Memory;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;metabolomics;microbial;Modification;mouse model;Multiple Sclerosis;Mus;new therapeutic target;novel;novel therapeutic intervention;Outcome Study;Oxidative Phosphorylation;Pathology;Pathway interactions;Patients;Phenotype;Play;primary outcome;programs;Psoriasis;Regulation;Research;Research Project Grants;Resources;Role;Signal Transduction;Skin;skin disorder;skin organogenesis;Skin Tissue;Specificity;T-Lymphocyte;Testing;Therapeutic;Time;Tissues;transcriptome sequencing;transcriptomics;treatment strategy

PROJECT_TITLE: Metabolomics and transcriptomics analyses of cell-specific regulation of fatty acid synthesis and metabolic reprogramming in skin inflammation

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative N/A – this section is not applicable.

PI_NAMEs: LOOMIS, JOSEPH F (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TITLE: Identifying Novel Signaling Mechanisms Downstream of Cardiac Gq-Coupled Receptors


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: NEW YORK

PHR: PROJECT NARRATIVE Prelamin A is protein that is processed by an enzyme called ZMPSTE24 into to lamin A, a structural component of the cell nucleus. Alterations in prelamin A and ZMPSTE24 have been implicated in accelerated aging syndromes and possibly normal aging. This project will dissect their roles in accelerated aging.

PI_NAMEs: WORMAN, HOWARD J (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Acceleration;age acceleration;Aging;aging related disease;Amino Acid Substitution;Amino Acids;Arginine;Automobile Driving;Cell Nucleus;Cellular Structures;Data;Defect;Disease;Dysplasia;Enzymes;farnesylation;Future;Genes;Grant;Human;insight;Intermediate Filament Proteins;Lamin Type A;Lead;Learning;Length;Leucine;life span;Longevity;loss of function;Mediating;Metalloproteases;Modeling;mouse model;Mus;Mutant Strains Mice;Mutation;Neonatal;normal aging;Nuclear Lamina;Outcome;Pathogenicity;Patients;Phenotype;Physiological;Point Mutation;prelamin A;Process;Progeria;Proteins;Reaction;Research Project Grants;Residual state;Resources;Role;Severities;Site;Syndrome;Testing;Time;Variant;Zinc

PROJECT_TITLE: Using mouse models to dissect the roles of ZMPSTE24 and prelamin A in accelerated aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

PHR: Project Narrative The exploratory studies will benefit the underserved rural areas and pediatric population. We will use the volumetric absorptive microsampling technique for dried blood spot sample collection combined with the highly sensitive ultra-performance liquid chromatography tandem mass spectrometry for drug quantitation to build a platform for pharmacokinetic/pharmacodynamic studies of antimalarial drugs including lumefantrine, amodiaquine, and piperaquine in rural areas. The patient-centered, field-friendly dried blood spot method will help to expand clinical studies to underserved rural area in Africa and facilitate studies in the pediatric population.

PI_NAMEs: HUANG, LIUSHENG  (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Accounting;Achievement;Adherence;Africa;Amodiaquine;Anti-malarials;Artemisinins;benflumetol;Binding Proteins;Biological Assay;Blood;Blood Cells;Blood specimen;Blood Volume;chemical property;Chemoprevention;Childhood;Clinical;Clinical Research;Clinical Trials;clinically relevant;Collection;Combined Modality Therapy;Communicable Diseases;cost;Coupled;Cryopreservation;Data;Development;Devices;drug distribution;Drug Exposure;Drug Kinetics;Drug resistance;Drug toxicity;Drug usage;Dryness;Enrollment;Equation;Erythrocytes;Evaluation;Friends;Future;Goals;Guidelines;Hematocrit procedure;improved;Infection;Investigation;Knowledge;Link;Liquid Chromatography;Malaria;Measurement;Measures;Methods;Modeling;Modernization;novel;Outcome;patient oriented;Patients;pediatric patients;Performance;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Plasma;Population;Prediction of Response to Therapy;Preparation;Prevention;Prevention trial;Recovery;Recrudescences;Reproducibility;Research;Resistance;Risk;rural area;sample collection;Sampling;Spottings;success;Support Groups;System;tandem mass spectrometry;Techniques;Temperature;Testing;Uganda;underserved rural area;Validation

PROJECT_TITLE: Precise field-friendly methods for quantification of antimalarial drugs in dried blood spots

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Immunotherapy;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE This project studies host defense against tuberculosis. Based on promising early evidence, we will test the role of an immune cell factor called NR4A1 in the response to tuberculosis infection, and the effect of NR4A1 inhibition on tuberculosis outcomes. Results from this study will shed light on protective immunity and could result in the development of new treatments for this important disease.

PI_NAMEs: KORNFELD, HARDY  (contact);SINGHAL, AMIT

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Abbreviations;Adoptive Transfer;Aerosols;alternative treatment;antagonist;antimicrobial;Antimycobacterial Agents;Bacillus;base;Binding;CD3 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cells;Cellular Immunity;Coculture Techniques;Colony-forming units;cytokine;Cytoprotection;cytotoxicity;Data;Development;digital;Disease;Effector Cell;efficacy testing;Ensure;Environment;exhaustion;experimental study;Funding;Future;Gene Expression;Gene Expression Regulation;Generations;Goals;Granzyme;Harvest;Host Defense;Immune;Immunity;Immunoglobulins;Immunohistochemistry;In Vitro;Infection;Infiltration;inhibitor;insight;IRF4 gene;Knock-out;Knockout Mice;Lesion;Leukocytes;Link;Lung;Lung infections;Mediating;Messenger RNA;Modeling;Mouse Strains;Mus;Mycobacterium tuberculosis;novel;NR4A1 gene;Outcome;Outcome Measure;pathogen;Pathway interactions;Peritoneal Macrophages;permissiveness;Pharmaceutical Preparations;Phenotype;Production;promoter;protective efficacy;Publications;Pulmonary Tuberculosis;Rag1 Mouse;Receptor Signaling;Regulation;Regulatory T-Lymphocyte;Repression;Reproducibility;Research;Resistance;response;restraint;Role;sex;Signal Transduction;single-cell RNA sequencing;T-Cell Receptor;T-Lymphocyte;Testing;Thioglycolates;transcription factor;Transcription Factor AP-1;transcriptome sequencing;transcriptomics;translational potential;Treatment Protocols;Tuberculosis;tuberculosis immunity;tuberculosis treatment;Up-Regulation;Wild Type Mouse

PROJECT_TITLE: Unleashing CD8+ T Cells for TB Defense

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Disability Research;Fetal Alcohol Spectrum Disorders (FASD);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative This project aims to test the feasibility and initial effectiveness of the Families Moving Forward Bridges early intervention model developed for caregivers of infants and toddlers with prenatal alcohol exposure. Phase 1 will be a feasibility study and Phase 2 will be a pilot randomized controlled trial to lay groundwork for a larger clinical trial. In both studies the intervention will be tested in community-based early intervention settings.

PI_NAMEs: JIRIKOWIC, TRACY L (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: Address;Affect;Age;Birth;Brain;Brain Injuries;Caregivers;Caring;Child;Child Development;Child Rearing;Clinical Trials;Communities;community partners;community setting;Community Trial;Complex;Data;design;Development;Diagnosis;disability;disability risk;dyadic interaction;early childhood;Early Intervention;Effectiveness;efficacy evaluation;Elements;Enrollment;evidence base;Evidence based practice;experience;Family;Family Study;family support;Feasibility Studies;feasibility testing;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;follow-up;foster care;Future;General Population;Goals;implementation intervention;Individual;Individuals with Disabilities Education Act;Infant;innovation;Intervention;intervention program;intervention refinement;Intervention Studies;Learning;Life;Manuals;Measures;Methods;Modeling;Neurodevelopmental Disability;Neurodevelopmental Problem;Nursery Schools;Outcome;Parent-Child Relations;parenting intervention;Parents;Participant;Phase;Prevalence;primary caregiver;Problem behavior;programs;protective factors;provider intervention;psychosocial;Public Health;Randomized;Randomized, Controlled Trials;Reporting;Research;Research Design;Resources;Risk;satisfaction;School-Age Population;service intervention;Services;Site;Social outcome;Specialist;Stress;Teratogenic effects;Testing;therapy design;Time;Toddler;Training;treatment as usual;trend;Underserved Population;United States;Vulnerable Populations;Waiting Lists

PROJECT_TITLE: Families Moving Forward Bridges: An Early Intervention Enhancement for Infants and Toddlers with Prenatal Alcohol Exposure with or at-risk for Fetal Alcohol Spectrum Disorders

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2 (AA)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking

PHR: PROJECT NARRATIVE The parent application involves secondary analyses of accelerated longitudinal cohort sequential data (collected from 2015–2021) from the Washington State Young Adult Health Study to examine changes in young adult substance use, related risk behaviors, and substance use related risk factors from before to during the COVID-19 pandemic among young adults in a state where alcohol, tobacco, and cannabis sales and use are legal for adults age 21 and over. This supplement will build on the parent grant by adding a new wave of data that was collected from this sample in the summer and fall of 2022, thereby allowing us to examine longer-term changes in these outcomes. Findings from this supplement will bolster the original aims of the parent study and inform tailoring and development of prevention and intervention efforts aimed at reducing problem behaviors and improving public health after situations that pose serious challenges for effective long-term planning of such efforts.

PI_NAMEs: GUTTMANNOVA, KATARINA  (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: 21 year old;Acceleration;Administrative Supplement;Adult;Age;Alcohol consumption;Alcohols;Automobile Driving;behavioral health;Cannabis;cannabis use behavior;Characteristics;Clinical;cohort;community-level factor;comparison group;COVID-19 pandemic;Data;Data Collection;Development;Driving While Intoxicated;Ethnic Origin;falls;Frequencies;Funding;gender minority status;Health;health disparity;health equity;Health Surveys;improved;Individual;Intervention;Legal;Lifting;long term COVID-19 pandemic impacts;Longitudinal cohort;marginalized population;marijuana use;Masks;Mental Health;Methodology;National Institute of Drug Abuse;neighborhood disadvantage;Outcome;pandemic disease;parent grant;Parents;Pattern;Persons;Policies;Prevalence;Prevention;Problem behavior;Productivity;Property;protective factors;Psychometrics;Public Health;Race;Recording of previous events;Recovery;Risk;Risk Behaviors;Risk Factors;Role;Sales;Sample Size;Sampling;secondary analysis;sex;Sexual and Gender Minorities;Societies;sociodemographics;Source;substance use;Time;Tobacco;Tobacco use;university student;Washington;Work;young adult

PROJECT_TITLE: Covid-19 pandemic and changes in the prevalence, patterns, and trajectories of substance use and related health risk outcomes among young adults in WA State: Administrative supplement.


PHR: PROJECT NARRATIVE In response to the pressing need for improved vaccination effectiveness, this proposal sets out to unlock the potential of the microbiota-stromal cell axis, a relatively uncharted territory due to stromal cell complexity and research limitations. Recent evidence highlights the critical role of stromal cells in shaping the local immune environment through the release of chemokines and cytokines. Building upon a groundbreaking prior study by the Principal Investigator demonstrating stromal cells' unique ability to recognize bacterial signals and trigger distinct immune responses, this proposal aims to harness this axis to develop microbiota-targeted therapies, promising a transformative approach to enhancing vaccine-induced immunity and ultimately advancing global health.

PI_NAMEs: WU, MENG  (contact)

PROJECT_TERMS: Achievement;Affect;Age;Animal Model;Antibodies;Antibody Formation;B-Cell Activation;B-Cell Development;B-Lymphocytes;Bacterial Genes;cancer immunotherapy;Cell Physiology;Cell Therapy;Cells;chemokine;Cholera Vaccine;Clinical Research;Communities;Complex;cost effective;cost effective intervention;COVID-19 pandemic;cytokine;Development;Diet Modification;Effectiveness;Elderly;Environment;Exhibits;experience;Future;Gastrointestinal tract structure;Genetic;Germ-Free;global health;Gnotobiotic;Growth;gut microbiota;Heterogeneity;Human;Immune;Immune response;Immune system;Immune System Diseases;Immunity;Immunization;Immunocompromised Host;Immunologic Factors;Immunology;immunoregulation;improved;Individual;infancy;Infant;Inflammatory Bowel Diseases;innovation;insight;interdisciplinary approach;interest;Intervention;Intestines;Lead;low and middle-income countries;Mediating;Mediator;medical schools;Medicine;microbial;microbiota;microbiota composition;microorganism;Molecular;mortality;mouse model;Mus;novel;Oral;Plasma Cells;Play;Population;Populations at Risk;Positioning Attribute;prebiotics;Principal Investigator;Probiotics;Proteomics;Public Health;Research;Resources;response;Role;Sampling;Shapes;Signal Transduction;single-cell RNA sequencing;Site;skills;Stromal Cells;System;Systems Biology;targeted treatment;Testing;Therapeutic;tool;translational medicine;transmission process;Universities;Vaccination;vaccine effectiveness;vaccine efficacy;vaccine immunogenicity;vaccine response;vaccine-induced immunity;Vaccines;vaccinology;Vulnerable Populations;Washington

PROJECT_TITLE: Exploiting the microbiota-stromal cell axis for microbiota-targeted medicine


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dystonia;Eye Disease and Disorders of Vision;Natural Products;Neurodegenerative;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Blepharospasm is a rare but debilitating neurologic disorder that produces involuntary abnormal facial expressions and eye closures. Many patients do not get satisfactory benefit from current treatment options, and the conventional methods for evaluating the impact of new treatments have several limitations. This project will evaluate new methods for measuring treatment impact based on computer analyses of video recordings of patients, thereby optimizing the potential for evaluating the outcome of multi-site clinical trials of future treatments.

PI_NAMEs: PETERSON, DAVID A (contact)

PROGRAM_OFFICER_NAME: CHEN, ALICE

PROJECT_TERMS: Acceleration;analog;Anxiety;Blepharospasm;Blinking;botulinum neurotoxin injection;botulinum toxin treatment;Botulinum Toxins;Clinical;clinical care;clinical outcome assessment;Clinical Trials;Computer Analysis;Computer Vision Systems;Data Set;Disease;Dose Limiting;Dystonia;Exhibits;Eye;Face;Facial Expression;Facial Muscles;Fatigue;Focal Dystonias;Future;Image;impression;improved;Intervention;Measurement;Measures;Mental Depression;Methods;Motor;motor impairment;motor symptom;Multi-Institutional Clinical Trial;Nervous System Disorder;non-motor symptom;Oral;Outcome;Outcome Assessment;participant enrollment;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Reporting;response;Sample Size;Self Assessment;Self Perception;Severities;side effect;software development;Spasm;System;Technology;Testing;Time;treatment choice;treatment effect;treatment response;Validation;Video Recording;Visual

PROJECT_TITLE: Triangulating outcome assessments for blepharospasm

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-3 (02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Electronic Nicotine Delivery Systems;Mental Health;Pediatric;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

PHR: PROJECT NARRATIVE Over 2 million adolescents use e-cigarettes, and it is important to develop interventions to help them quit. This proposal will test the use of a novel smartphone app that uses a multi-media and interactive format to teach coping and refusal skills and help adolescents quit using e-cigarettes.

PI_NAMEs: KRISHNAN-SARIN, SUCHITRA  (contact)

PROGRAM_OFFICER_NAME: MAYNE, RACHEL G

PROJECT_TERMS: Abstinence;addiction;Address;Administrator;Adolescence;Adolescent;adolescent substance use;Anxiety;Biochemical;cannabis use behavior;Cigar;Cigarette;Cognitive Therapy;comparison control;Computers;coping;Coping Skills;Cotinine;Cues;Decision Making;Dependence;design;Devices;digital applications;digital intervention;digital platform;Dissemination and Implementation;dissemination strategy;e-cigarette cessation;Education;Educational process of instructing;efficacy evaluation;Electronic cigarette;electronic cigarette use;electronic cigarette user;Emotions;Enrollment;Exercise;experience;Feedback;Focus Groups;Frequencies;Future;Health;high school;Individual;innovation;Intervention;Interview;Knowledge;Learning;marijuana use;Mental Depression;Methods;model design;Modeling;Motivation;Multimedia;Narration;Nicotine;Nicotine Dependence;nicotine use;novel;open label;Operating System;Outcome;Patient Self-Report;Pattern;peer coaching;Persons;Preparation;Prevalence;primary outcome;Randomized;Randomized, Controlled Trials;retention rate;Role playing therapy;Salivary;Schools;secondary outcome;sex;skills;smartphone application;Smoke;Smokeless;smoking cessation;Smoking Cessation Intervention;Structure;Testing;Text;Text Messaging;Therapeutic Intervention;Tobacco;Tobacco use;user-friendly;vaping;virtual;web page;Withdrawal;Work;young adult;Youth

PROJECT_TITLE: Vaping Cessation among youth: Evaluating the feasibility and efficacy of a virtual in-person CBT and an app-based CBT4CBT

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-6 (M2)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Congenital Structural Anomalies;Estrogen;Genetics;Mental Health;Neurosciences;Nutrition;Obesity;Pediatric;Rare Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Narrative: As MAGEL2 in hypothalamic POMC neurons plays a crucial role in the development and maintenance of central melanocortin circuits, elucidating the cellular mechanisms by which MAGEL2 in hypothalamic POMC neurons innervating the medial amygdala controls body weight and anxiety-like behavior will pave the way for novel therapeutic interventions for the treatment of obesity and mental illness in individuals with PWS.

PI_NAMEs: JO, YOUNG-HWAN  (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Adult;Affect;Aggressive behavior;Amygdaloid structure;Anti-Anxiety Agents;Anxiety;anxiety-like behavior;Behavior;behavior test;Body Weight;Body Weight decreased;Brain;Cell Physiology;Characteristics;Child;Control Groups;Darkness;Desire for food;Development;diet-induced obesity;Disease;emotional behavior;Energy Metabolism;ESR1 gene;Estrogen Nuclear Receptor;Estrogen Therapy;Estrogens;Etiology;excessive weight gain;Exhibits;experimental study;Female;Fertility;Food;Gene Cluster;Genes;Goals;Gonadal Steroid Hormones;GPER gene;Growth;High Fat Diet;Home;Human;Hyperphagia;Hypothalamic structure;Impairment;Individual;Investigation;knock-down;Knockout Mice;Light;loss of function;Maintenance;male;Medial;Melanocyte stimulating hormone;Mental disorders;Messenger RNA;Metabolic;metabolic phenotype;Metabolism;Motivation;mouse model;Mus;neural circuit;neurogenetics;Neurons;Neuropeptides;novel;novel therapeutic intervention;Obesity;obesity treatment;Obsessive compulsive behavior;Overweight;Pathology;Pathway interactions;Phenotype;Pilot Projects;Plasma;Play;Prader-Willi Syndrome;Predisposition;Pro-Opiomelanocortin;Production;Publishing;Research;Rodent;Role;Secretory Vesicles;Social Behavior;social cognition;Social Controls;Structure;Structure of nucleus infundibularis hypothalami;System;Testing;Weight Gain;α-Melanocyte stimulating hormone

PROJECT_TITLE: Role of hypothalamic MAGEL2 in motivation

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-8 (01)]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Cardiovascular;Complementary and Integrative Health;Diabetes;Nanotechnology;Nutrition;Prevention;Transplantation

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE Islet transplantation is a promising treatment for patients with type 1 diabetes and late-stage chronic pancreatitis. However, severe inflammation occurs during the process of islet infusion into the liver, leading to islet death. The goal of the proposed work is to develop a therapeutic to combat inflammation and preserve islet viability.

PI_NAMEs: BURKE, JACQUELINE ALEXIS (contact)

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: Address;Adverse effects;Antigen-Presenting Cells;Antiinflammatory Effect;Antioxidants;Aortitis;Apolipoprotein E;Apoptosis;Arterial Fatty Streak;Biocompatible Materials;Biological Availability;biomaterial compatibility;Blood;Blood Platelets;CD80 gene;Cell Aggregation;Cell Membrane Permeability;cell type;Cells;Cessation of life;Characteristics;Cholecalciferol;Chronic;chronic pancreatitis;Clinical;Coagulation Process;combat;Complement Activation;cytokine;Dendritic Cells;Devices;Dextran Sulfate;dihydroxy-vitamin D3;Down-Regulation;Drug Delivery Systems;Drug Targeting;Encapsulated;Endocytosis;Endothelial Cells;Engraftment;ethylene glycol;Event;Fibrinolytic Agents;Generations;Glucose;Goals;Hematology;Hemorrhage;Hemostatic function;Heparin;Hepatic;High Fat Diet;Hour;Human;hydrophilicity;Hydrophobicity;Hypoxia;immunoregulation;in vivo;Inflammation;Inflammatory;inflammatory marker;inflammatory modulation;Infusion procedures;inhibitor;Insulin;Insulin-Dependent Diabetes Mellitus;intravenous administration;intravenous injection;islet;Islets of Langerhans Transplantation;Leukocytes;Lipids;Liver;Macrophage;Mediating;minimally invasive;Modeling;Modification;Molecular Weight;monocyte;Mus;nanocapsule;nanocarrier;nanoparticle;nanopolymer;nanoscale;nanotherapeutic;Nature;Necrosis;NF-kappa B;nuclear factor-erythroid 2;Nutrient;oxidation;Oxidative Stress;Oxygen;Pathway interactions;Patients;Phagocytes;Pharmaceutical Preparations;Phenotype;Population;Portal vein structure;preservation;pressure;prevent;Procedures;Process;Production;propylene;Publishing;Reaction;Reactive Oxygen Species;response;Risk;Route;Safety;Signal Transduction;Site;Spleen;Stress;Sulfides;Surface;targeted delivery;Therapeutic;thromboinflammation;Thromboplastin;Thrombosis;Tissues;Toxic effect;transplant model;Transplantation;Treatment Efficacy;Tube;Vitamin D;Vitamin D3 Receptor;Work

PROJECT_TITLE: Intracellular Vitamin D to Combat Instant Blood-Mediated Inflammatory Reaction

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]