ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

PHR: PROJECT NARRATIVE Cytoplasmic dynein is vital to various eukaryotic activities, and mutations in dynein and its largest regulatory complex dynactin, cause human neurological disease. We are studying the molecular mechanisms that underlie the function and dysfunction of the dynein-dynactin complex.

PI_NAMEs: GENNERICH, ARNE  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Affect;Amino Acids;ATP phosphohydrolase;base;Behavior;Binding;Biological Assay;Brain;brain malformation;Cell Physiology;Cerebral cortex;Child;cofactor;Color;Complex;Congenital Abnormality;Cytoplasm;Data;Defect;Degenerative Disorder;Development;developmental disease;Dimerization;Disease;Dissociation;dynactin;Dynein ATPase;Embryonic Development;Engineering;Epilepsy;Etiology;Fluorescence;Fluorescence Microscopy;Functional disorder;Future;Generations;genetic regulatory protein;Goals;Homologous Gene;Human;human disease;improved;Infant;innovation;insight;Intracellular Transport;laser tweezer;Life;Link;lissencephaly;Measurement;Mediating;Microtubules;migration;Molecular;Molecular Conformation;Molecular Target;Motility;Motion;Motor;Movement;Mutagenesis;Mutation;nanoscale;nerve stem cell;Nervous System Disorder;Neurons;novel;optic tweezer;Output;Pattern;Process;Proliferating;Protein Engineering;recruit;Registries;Regulation;Reporting;Saccharomyces cerevisiae;single molecule;Slide;stem cell division;System;Tail;Testing;Therapeutic Intervention;therapy development;Time;Variant;Visualization

PROJECT_TITLE: Molecular Mechanism of the Cytoplasmic Dynein-Dynactin Motor Complex

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Schizophrenia;Serious Mental Illness

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: PROJECT NARRATIVE Africa, the birthplace of modern humans, is the single most informative continent for understanding the human genome and human disorders with worldwide impact. Since most genomic research has not involved African populations, generations of human genetic history are missing from our understanding of human genetics and complex disease. In this study, we will use novel whole genome sequencing strategies to characterize the genetic bases of schizophrenia in the Xhosa population of South Africa.

PI_NAMEs: STEIN, DAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Africa;African;African ancestry;Age;Alleles;base;Binding;Blood;Brain;Cell Line;Code;Complex;Consent;Copy Number Polymorphism;Custom;Detection;Diagnosis;Disease;DNA Transposable Elements;Enhancers;Enrollment;experience;Gender;Generations;Genes;Genetic;genetic architecture;Genetic Diseases;Genetic study;Genetic Variation;genome sequencing;Genomic DNA;Genomics;Genotype;Goals;Grant;Human;Human Genetics;Human Genome;human genomics;human reference genome;Human Resources;Individual;Infrastructure;insertion/deletion mutation;International;international partnership;Link;Location;lymphoblast;Modeling;Modernization;Mutation;New York;novel;Participant;Phase;Phenotype;Point Mutation;Population;Privatization;Productivity;promoter;Protocols documentation;Recording of previous events;recruit;Regulatory Element;Research;Research Personnel;response;risk variant;Role;Sample Size;Sampling;Schizophrenia;Science;screening;Signal Transduction;Site;SNP array;South Africa;South African;Structure;study population;Synapses;synaptic function;Technology;Testing;transcription factor;Universities;Untranslated RNA;Variant;Washington;whole genome

PROJECT_TITLE: 3/3 Genomics of Schizophrenia in the South African Xhosa


ADMINISTERING_IC: NS

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: CAMBRIDGE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PI_NAMEs: FEDORENKO, EVELINA  (contact);RICHARDSON, ROBERT MARK

PROGRAM_OFFICER_NAME: GEBREHIWET, HERMON RUSSOM

PROJECT_TERMS: Architecture;Area;artificial neural network;Brain;Brain Injuries;Charge;Code;Cognition;Complement;Complex;computational neuroscience;Computer Models;Data;Data Set;design;Disease;Foundations;Functional Magnetic Resonance Imaging;Human;human data;human model;Influentials;Investigation;Language;Language Development;language impairment;language processing;Left;lens;Lesion;lexical;Linguistics;Machine Learning;Modeling;network models;neural;neural network;Neural Network Simulation;neuroimaging;Noise;Patients;Performance;phrases;Population;Psycholinguistics;Research;response;Sampling;Science;semantic processing;Semantics;Stimulus;Structure;synergism;syntax;System;Testing;Time;Training;Variant;Word Processing;Work

PROJECT_TITLE: Computational Neuroscience of Language Processing in the Human Brain


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: CHESTNUT HILL

ORG_DEPT: BIOLOGY

ORG_NAME: BOSTON COLLEGE

PHR: PROJECT NARRATIVE Maintenance of cell shape and growth pattern is necessary for proper function, development and differentiation for most organisms. This project will investigate how cells modulate their shape and growth pattern in response to its corresponding cell-cycle stage. In the long term, understanding how cell-cycle cues regulate cell shape can potentially lead to novel therapeutic and diagnostic targets for diseases such as cancer and neuronal disorders.

PI_NAMEs: DAS, MAITREYI  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Biological Models;Cell Cycle;Cell Cycle Stage;Cell division;cell growth;Cell Maintenance;Cell Polarity;Cell Shape;Cells;Cellular biology;Chemicals;Complex;Cues;Cyclin B;Cytokinesis;Data;Development;Diagnostic;Disease;Eukaryota;Fission Yeast;G1 Arrest;G2 Phase;Generations;Genetic;Growth;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;insight;Investigation;live cell imaging;Malignant Neoplasms;mathematical model;Membrane Proteins;Memory;Metabolic Diseases;Mitosis;Mitotic;Nature;Neurons;next generation;Normal Cell;novel diagnostics;novel therapeutics;Oranges;Organism;Pattern;Phase;polarized cell;preservation;Property;Proteins;recruit;Recurrence;Regulation;response;Rod;S phase;Shapes;Signal Transduction;Site;System;Testing;Therapeutic;Tissues;tool;yeast genetics

PROJECT_TITLE: Cell-cycle-dependent cell polarity control

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Despite recent advances, lung cancer five-year survival rates remain dismal. One barrier to progress is the identification of new treatment strategies for specific genotype-defined subsets of lung cancer. In this work, we characterize the mechanism of a little-studied new cancer oncogene, RIT1, and test two new therapeutic strategies for the treatment of RIT1-mutant lung cancer.

PI_NAMEs: BERGER, ALICE  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Antimitotic Agents;aurora kinase;aurora kinase A;Biochemical;Biological;BRAF gene;cancer cell;Cancer cell line;cancer subtypes;cancer therapy;Cells;Chromosomal Rearrangement;clinical practice;Clinical Trials;Complex;Coupled;CRISPR screen;Data;Development;Disease;driver mutation;Drug resistance;Drug Screening;efficacy testing;Epidermal Growth Factor Receptor;Epithelial Cells;Event;experimental study;Family;FDA approved;functional genomics;gain of function mutation;Genes;Genetic;Genetically Engineered Mouse;genome-wide;Genomics;Genotype;Germ Lines;Goals;Human;Impairment;improved;improved outcome;Individual;inhibitor;insight;kinase inhibitor;KRAS2 gene;Laboratories;Lung;Lung Adenocarcinoma;lung cancer cell;Lung Neoplasms;lung tumorigenesis;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Mediating;metaplastic cell transformation;Mitotic Checkpoint;Molecular;Monomeric GTP-Binding Proteins;mutant;Mutate;Mutation;Myeloid Leukemia;Nature;Noonan Syndrome;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;Oncogenic;overexpression;Pathogenicity;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pattern;Play;Postdoctoral Fellow;pre-clinical;precision oncology;Precision therapeutics;preclinical study;protein complex;Proteins;Proteomics;ras Proteins;Receptor Protein-Tyrosine Kinases;Regulation;Resistance;Role;Signal Transduction;small molecule;Structure;Survival Rate;synergism;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;Translating;translational potential;Translations;treatment strategy;tumor;tumorigenesis;tumorigenic;United States;Variant;Work

PROJECT_TITLE: Understanding and exploiting novel therapeutic vulnerabilities of RIT1-driven lung cancer

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Nanotechnology;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: ARLINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

ORG_STATE: TX

PHR: Project Narrative: The benefits of this research to the general public include the development of biomaterials that can be used as effective therapies in promoting faster or more improved methods of healing bone. This could potentially lead to improved healing, shortened healing times, and reduce health care costs associated with bone healing.

PI_NAMEs: VARANASI, VENU GOPAL (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: 3-Dimensional;Acceleration;angiogenesis;Angiopoietins;ANGPT1 gene;Antioxidants;Autologous;Autologous Transplantation;Biocompatible Materials;Biological Assay;biomaterial development;Biomaterials Research;Biomedical Engineering;Biopolymers;Blood Vessels;bone;Bone Density;Bone Growth;bone healing;Bone Matrix;Bone Morphogenetic Proteins;Bone Regeneration;bone repair;Bone Tissue;cell motility;Cells;Cephalic;Chemicals;Chemistry;Clinical;Clinical Trials;clinically relevant;Collagen;Complex;craniofacial;craniofacial bone;Cysteine;Data;Defect;density;Deposition;Development;Devices;Economic Burden;effective therapy;Electrons;Emergency department visit;Endothelial Cells;Environment;Enzyme-Linked Immunosorbent Assay;Excision;fabrication;FDA approved;Fracture;Future;GATA1 gene;Gelatin;General Population;Goals;Growth Factor;Harvest;healing;Health Care Costs;Histology;Human;hypoxia inducible factor 1;Implant;improved;In Vitro;in vivo;Inflammation;Injury;innovation;Ions;Lead;Lesion;Medical Care Costs;Mesenchymal Stem Cells;Methods;migration;Mission;Morbidity - disease rate;Morphology;Musculoskeletal;nanocomposite;nanoparticle;Natural regeneration;Nitrogen;nuclear factor-erythroid 2;Operative Surgical Procedures;Osteocalcin;Osteogenesis;osteogenic;Paste substance;Pathologic;Patients;Phosphorus;Polymers;preclinical study;Process;promoter;Proteins;Rattus;Reaction;Recombinants;reconstruction;Rehabilitation therapy;repaired;Research;Research Personnel;Roentgen Rays;sample fixation;scaffold;Scientist;Semiconductors;Signal Transduction;Silicon;Site;socioeconomics;Speed;stem cell differentiation;Stimulus;Structure;Swelling;Testing;Time;Tissues;Titanium;Translating;Translations;Trauma;United States National Institutes of Health;vapor;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Vascularization

PROJECT_TITLE: Semiconductor Biomaterials to Speed Bone Healing: A Bioengineering-Driven Approach

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_CITY: DURHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: RELEVANCE The goal of this project is to analyze the cell-type specific proteomes of presynaptic terminals and analyze how specific actin modulatory pathways within govern transmitter release and plasticity. In particular this grant focuses on the roles of Trio, a Rho-family GEF strongly implicated in human brain disorders. Uncovering these molecular mechanisms of presynaptic physiology can be expected to lead to better insights of disorder etiology and potential therapeutic approaches- both major goals of the NIH.

PI_NAMEs: SODERLING, SCOTT H (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Actins;Action Potentials;Basic Science;Behavior;behavior test;Biotin;Biotinylation;Brain Diseases;cell type;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Coupled;Coupling;CRISPR/Cas technology;cytomatrix;Cytoskeleton;Data;Development;Disease;Electrophysiology (science);Elements;Etiology;Event;Family;follow-up;Fractionation;functional plasticity;Future;Gene Mutation;Genetic;genome editing;Genome engineering;Goals;Grant;Hippocampus;Human;Image;In Vitro;in vivo;innovation;insight;Knowledge;Label;Learning;Link;Mass Spectrum Analysis;Mediating;Memory;Methods;Molecular;Mus;mutant;Mutation;Nature;Neurodevelopmental Disorder;Neurons;novel strategies;optogenetics;Pathway interactions;pharmacologic;Physiology;postsynaptic;presynaptic;Presynaptic Terminals;Process;Property;protein complex;Proteins;Proteome;Proteomics;Regulation;response;rho;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Structure;Synapses;Synapsins;synaptic function;Synaptic plasticity;Synaptic Transmission;Synaptic Vesicles;Synaptosomes;Testing;Therapeutic;Time;time use;tool;Transgenic Mice;two-photon;United States National Institutes of Health;Vertebral column;Vesicle

PROJECT_TITLE: Proteomic and Functional Analysis of Presynaptic Physiology and Plasticity

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: TR

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: The Harold and Muriel Block Institute for Clinical and Translational Research (ICTR), a partnership between the Albert Einstein College of Medicine and Montefiore Medical Center, aims to create a robust and collaborative research enterprise that is committed to advancing clinical and translational science and promoting health equity. The ICTR will catalyze innovations to overcome research roadblocks across the translational spectrum, and will create and maintain a skilled and diverse research workforce, to accelerate the process of turning discoveries in the laboratory, clinic, and community, into health benefits for all.

PI_NAMEs: KAHN, JESSICA  (contact);KIM, MIMI Y

PROGRAM_OFFICER_NAME: GANNOT, GALLYA

PROJECT_TERMS: Abbreviations;Acceleration;Biomedical Research;Cessation of life;Clinic;Clinical;Clinical and Translational Science Awards;Clinical Engineering;Clinical Informatics;Clinical Research;Clinical Sciences;clinical trial recruitment;college;Communication;Communities;community engagement;community partnership;County;COVID-19 pandemic;COVID-19 vaccination;Data Science;data sharing;Discipline of Nursing;disorder prevention;Dissemination and Implementation;Effectiveness;Electronic Health Record;Ensure;Environment;ethnic minority;Ethnic Origin;Evaluation;Evidence based program;Exclusion;Funding;Goals;Health;Health Benefit;health care quality;health disparity;health equity;health equity promotion;health inequalities;Health Professional;Health system;Healthcare;Hispanic-serving Institution;Home;implementation strategy;improved;inequitable distribution;Informatics;Infrastructure;innovation;Institution;Laboratories;large datasets;Lead;Leadership;Learning;Life Cycle Stages;Medical center;Medicine;member;Mentors;Methodology;multidisciplinary;novel;open data;Operations Research;Participant;Pathway interactions;patient population;Patients;population health;Population Research;Post-Acute Sequelae of SARS-CoV-2 Infection;premature;Prevention strategy;Process;process improvement;programs;Protocols documentation;Public Health;Race;racial minority;Reduce health disparities;Research;Research Design;Research Personnel;Resource Informatics;Resources;Safety;Science;Services;skills;social health determinants;socioeconomics;study population;Target Populations;Technology;Therapeutic;Training;Training Programs;Translation Process;translational pipeline;Translational Research;Translations;treatment strategy;uptake;vaccine acceptance;Vision;Woman

PROJECT_TITLE: Einstein-Montefiore Clinical and Translational Science Award Hub


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Acne vulgaris affects nearly every human being and costs the United states approximately $1.3 billion/year, yet most acne treatments are temporary and kill a microbe that is sensitive to light from the sun. The microbial biology leading to this susceptibility is poorly understood, but recent work indicates that acne can be cured using a non-antimicrobial drug that favors microbes with specific differences in this biology. Using samples from this recent work, we will identify which microbial metabolic pathways associate with acne remission and if the biology of light susceptibility can be targeted to cure acne rather than temporarily clear it.

PI_NAMEs: MCCOY IV, WILLIAM HOWARD (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Acne;Acne Vulgaris;Affect;Anaerobic Bacteria;Antibiotics;Award;Binding;Biochemical;Biological Process;Biology;career;career development;Chelating Agents;chelation;Clinical;commensal bacteria;Communities;consumer product;cost;Dairy Products;Dermatology;Disease;Disease remission;Doctor of Medicine;Doctor of Philosophy;Dryness;Environment;Exanthema;experience;Faculty;Foundations;Funding;gene synthesis;Genes;Genome;Genomics;Goals;Grant;Growth;Heme;heme-binding protein;Hemolysin;high school;Human;human pathogen;human study;Immune system;Immunology;improved;Infection;Infection prevention;Inflammation;Inflammatory;Institution;Investigation;Iron;Isotretinoin;Leukocyte L1 Antigen Complex;Light;Mass Spectrum Analysis;Medical Research;medical schools;meetings;Mentors;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Metagenomics;metal chelator;Metal exposure;metal metabolism;Metals;Microbe;microbial;Micronutrients;microorganism growth;Modeling;novel;novel therapeutics;Nutritional Immunity;oxidation;pathogen;Pathway interactions;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Phototherapy;Physicians;Porphyrins;Positioning Attribute;Predisposition;pressure;Propionibacterium;Propionibacterium acnes;Protein Secretion;Proteins;psoriasin;Publishing;Research;Research Design;Research Personnel;Resource Development;response;Role;Running;Sampling;Scientist;Secure;skills;Skin;Skin colonization;skin disorder;skin microbiome;skin microbiota;Structure;Sunlight;Swab;System;Techniques;tenure track;Testing;Trace metal;Training;transcriptome sequencing;Transition Elements;Translational Research;United States;United States National Institutes of Health;Universities;Virulence Factors;Virulent;Washington;water conservation;Wood material;Work

PROJECT_TITLE: Mechanistic Investigations of Sebaceous Skin Microbial Community Remodeling in Acne Remission

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cystic Fibrosis;Lung;Rare Diseases

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Muco-obstructive airway diseases, including chronic obstructive pulmonary disease (COPD), asthma, cystic fibrosis (CF), and non-CF bronchiectasis are punctuated by exacerbations that lead to mucous hypersecretion by secretory cells and mucous plugging of the airways. Little is known about how the airway epithelial cells returns to normal during resolution. In this application, we propose that resolution of airway exacerbations occurs by degradation of the mucin granule in secretory cells by the autophagy pathway.

PI_NAMEs: DICKINSON, JOHN DAVID (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Acceleration;Airway Disease;airway epithelium;Apical;Asthma;Autophagocytosis;Autophagosome;Biogenesis;Bronchiectasis;Cell Culture Techniques;Cell Differentiation process;Cells;Cellular Morphology;Chronic Obstructive Pulmonary Disease;Conceptions;Cystic Fibrosis;Cytoplasm;Cytoplasmic Granules;Data;data centers;Degradation Pathway;Disease;Epithelial Cells;Epithelium;Equilibrium;FRAP1 gene;Genes;Genetic;Goblet Cells;Homeostasis;Hospitalization;Human;in vivo;Infection;Inflammation;inhibition of autophagy;Kinetics;Knowledge;Lysosomes;Measures;Mediating;Membrane;Metabolism;Metaplasia;Modeling;mortality risk;mTOR inhibition;mTOR Inhibitor;MUC5AC gene;MUC5B gene;Mucins;muco-obstructive airway diseases;Mucous body substance;Mus;novel therapeutic intervention;Nutrient;nutrient deprivation;Organelles;Pathologic;Pathway interactions;Patients;pharmacologic;Process;Production;programs;protein degradation;Proteins;pulmonary function;Recycling;Regulator Genes;Research;Resolution;response;Role;Route;Secretory Cell;sensor;Signal Pathway;Signal Transduction;System;Testing;Therapeutic;trafficking;Vesicle

PROJECT_TITLE: Autophagy-mediated mucin degradation is necessary for resolution of mucous metaplasia

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Sleep Research;Substance Misuse;Underage Drinking

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PUBLIC HEALTH NARRATIVE This study seeks to better characterize the longitudinal variability in heavy drinking and alcohol use disorder risk in young adults via a multimethod approach that takes advantage of the latest innovations in web-based neuropsychological assessment, smartphone sensing, and machine learning and statistical modeling. The results will help advance alcohol use disorder precision medicine initiatives targeting this vulnerable developmental transition from adolescence to adulthood.

PI_NAMEs: DEMARTINI, KELLY S;FUCITO, LISA M (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: addiction;Address;Adult;Age;Alcohol consumption;alcohol misuse;Alcohol Phenotype;alcohol related consequences;alcohol research;alcohol risk;alcohol use disorder;Alcohols;Behavior;Behavioral;Biological;Brain;Cellular Phone;Characteristics;Chronic;circadian;Circadian Rhythms;Classification;Clinical;clinical heterogeneity;college;Communication;Computers;cost;Cost Analysis;Dairying;Data;Data Collection;deter alcohol use;Development;Diagnosis;diagnostic strategy;diaries;digital;Digital biomarker;digital data;Dimensions;Disease;disorder risk;Distal;drinking;emotional functioning;Environment;Equation;Ethnic Origin;executive function;Factor Analysis;follow-up;Functional disorder;Goals;Heavy Drinking;Heterogeneity;Hour;improved;incentive salience;Incidence;Individual Differences;innovation;Intervention;Longitudinal Studies;Machine Learning;Maps;Measurement;Measures;Mental disorders;Methods;Modeling;National Institute of Mental Health;National Institute on Alcohol Abuse and Alcoholism;neurobehavioral;Neurobiology;Neuropsychology;novel;Online Systems;Outcome;Participant;Patient Self-Report;Persons;Phenotype;Population;precision medicine;Precision Medicine Initiative;Prediction of Response to Therapy;Psychiatry;psychologic;Public Health;Questionnaires;Race;Recommendation;Reporting;Research;Research Domain Criteria;Risk;Science;sensor;sensor technology;sex;Sleep;social;Social Processes;Statistical Models;Surveys;Symptoms;System;Targeted Research;Telephone;Testing;time use;transition to adulthood;Translating;Treatment outcome;treatment response;validation studies;Work;World Health Organization;young adult;young adult alcohol use

PROJECT_TITLE: Deep Phenotyping of Heavy Drinking in Young Adults with Behavioral Scales, Neuropsychological Tasks, and Smartphone Sensing Technology

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ORG_CITY: ATLANTA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative Intervertebral disc diseases (IDD) continue to be major clinical dilemmas in orthopedics. IDD and associated back pain are significant public health as well as a substantial economic burdens on our society. The proposed work will establish the ability and underlying mechanisms of local delivery of PDGF, as a potential therapeutic strategy to inhibit the progression of IDD.

PI_NAMEs: DRISSI, MOULAY HICHAM (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Aftercare;Apoptosis;Apoptotic;Autophagocytosis;Autopsy;Back Pain;Becaplermin;Biocompatible Materials;Biological Assay;Biological Response Modifier Therapy;Biomechanics;Blood Platelets;cell growth;Cells;Chondrocytes;Clinical;Collagen;Complementary DNA;Cytokeratin;Data;Data Analyses;Databases;defined contribution;density;disability;Disease;Dose;Drug Delivery Systems;Economic Burden;Encapsulated;Engineering;Exposure to;FGF2 gene;GAG Gene;gain of function;Gene Expression;Generations;Genes;Genetic Transcription;global health;Goals;Growth Factor;Height;Histologic;Histology;Homeostasis;Human;human disease;Hydrogels;Image;improved;In Vitro;in vivo;Induction of Apoptosis;inhibitor;Injectable;Insulin-Like Growth Factor I;Intervertebral disc structure;intervertebral disk degeneration;knock-down;laser capture microdissection;Lasers;Light;Link;Literature;Low Back Pain;LoxP-flanked allele;Magnetic Resonance Imaging;Measures;mechanical properties;Mediating;Messenger RNA;Microscopy;Modality;Modeling;Molecular;monolayer;mouse model;Mus;Neck Pain;new therapeutic target;novel;nucleus pulposus;Operative Surgical Procedures;Orthopedics;Oryctolagus cuniculus;Outcome;Outcome Measure;overexpression;Pathway Analysis;Plasma;Platelet-Derived Growth Factor;platelet-derived growth factor AB;Platelet-Derived Growth Factor alpha Receptor;platelet-derived growth factor BB;Platelet-Derived Growth Factor beta Receptor;Pre-Clinical Model;preclinical study;Prevalence;Process;Production;promoter;Public Health;Publishing;Puncture procedure;Reporting;Repression;Research;response;Role;RUNX1 gene;second harmonic;Seminal;senescence;Serum;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;small hairpin RNA;societal costs;Societies;Starvation;Sulfate;Symptoms;Tail;Testing;Therapeutic;Therapeutic Effect;Tissues;transcription factor;transcriptomics;Transforming Growth Factor beta;Transgenic Organisms;Treatment Efficacy;Validation;Work

PROJECT_TITLE: Control of intervertebral disc degeneration via matrix-mediated delivery of platelet-derived growth factors


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Injury - Accidents and Adverse Effects;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Unintentional Childhood Injury

ORG_CITY: HOUSTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE The project is relevant to public health because Hypoxic-Ischemic Encephalopathy (HIE) is a type of brain injury that occurs in 1-3 per 1000 births. There is a great need to develop a bedside test in neonates with HIE to accurately predict which babies may have brain injury. Thus the proposed research is relevant to the part of the NIH’s mission that pertains to developing therapies that will help reduce the burden of human disability.

PI_NAMEs: GOETZL, LAURA  (contact);WEISS, MICHAEL D

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Acute;Acute Brain Injuries;adverse outcome;Affect;anti-depressive agents;Anti-Inflammatory Agents;Antioxidants;assay development;Astrocytes;Basal Ganglia;Bedside Testings;Biological Assay;Biological Markers;biomarker development;biomarker panel;Birth;Blood;Blood - brain barrier anatomy;Blood Volume;blood-brain barrier crossing;Brain Injuries;Brain region;cell type;Cells;Central Nervous System;Clinical;clinical predictors;Clinical Research;clinically relevant;contactin;cytokine;Data;Development;disability;Dose;Drug Targeting;Electroencephalography;Evaluation;Event;exosome;experience;Future;Goals;Human;improved;Incidence;Individual;Infant;infant brain injury;Inflammatory;inflammatory marker;infliximab;Injury;LCN2 gene;Live Birth;Magnetic Resonance;Magnetic Resonance Imaging;Managed Care;Measures;Melatonin;Melatonin Receptors;Mental Depression;Methods;Mission;Monitor;Morbidity - disease rate;nanovesicle;National Institute of Child Health and Human Development;natural hypothermia;Nature;Neonatal;neonatal encephalopathy;neonatal hypoxic-ischemic brain injury;neonate;neuroinflammation;Neurologic;Neurological outcome;neuronal survival;Neurons;neuroprotection;Neuroprotective Agents;novel;Organ;Outcome;Oxidative Stress;Pathologic;Pathologic Processes;Performance;Perinatal Brain Injury;Peripheral;peripheral blood;Pharmacology Study;Phase;Phase 0/1 Clinical Trial;Population;predict clinical outcome;Prognosis;prognostic;Proteins;Public Health;Recording of previous events;recruit;Research;Residual state;response;Risk;Sampling;Seizures;Sentinel;Serum;Severities;Source;standard of care;Surface;synaptopodin;Testing;Therapeutic;Therapeutic Effect;therapy development;Time;TNFRSF1A gene;Translating;treatment response;ultrasound;United States National Institutes of Health

PROJECT_TITLE: Central Nervous System Derived Exosomes: A Novel Source of Biomarkers for Neonatal Hypoxic Ischemic Encephalopathy

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

ORG_STATE: RI

PHR: NARRATIVE Emotion regulation (ER) problems are prevalent in young children living in poverty, and while high quality early care and education (ECE) programs are positioned to prevent child ER difficulties, they often fail to do so because teachers lack internal support to help them sustain evidence-based teaching practices and skills. Training ECE directors to provide enhanced supervision to their teachers may promote positive effects of ECE programming and adaptive ER in children. This study aims to refine and then test an intervention focused on training and supporting ECE directors in Reflective Practice and Supervision to dually target teaching and child outcomes.

PI_NAMEs: HUFFHINES, LINDSAY  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: acceptability and feasibility;Achievement;adolescent health;Age;Buffers;burnout;Businesses;career;Caring;catalyst;Child;Child Health;Clinical;Clinical Trials;Collaborations;Communities;community setting;Data;design;Development;Disease;early life adversity;Ecosystem;Education;Educational Curriculum;Educational process of instructing;Effectiveness;effectiveness/implementation trial;efficacy trial;emotion dysregulation;emotion regulation;Emotional;Emotions;empowerment;Ensure;Environment;Evaluation;evidence base;Evidence based practice;Exposure to;follow-up;Funding;Future;Goals;Head Start Program;high risk;Home visitation;Hospitals;implementation barriers;implementation facilitation;implementation facilitators;improved;Infant;innovation;interest;Intervention;Interview;knowledge base;Label;Leadership;Learning;Left;life span;Link;Measures;Mediator;medical schools;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Modeling;multilevel analysis;National Institute of Child Health and Human Development;novel;Nursery Schools;Outcome;Parents;peer;Phase;physical conditioning;Positioning Attribute;post intervention;Poverty;prevent;Prevention;Prevention approach;preventive intervention;Primary Prevention;programs;Psychological reinforcement;Psychopathology;Public Health;Randomized;Randomized, Controlled Trials;Records;Research;Resources;Rhode Island;Risk;Scientist;skills;Source;Stress;stressor;Structure;Supervision;Surveys;System;Systems Theory;teacher;Teacher Professional Development;Testing;Time;Training;transition to adulthood;Validation;Waiting Lists

PROJECT_TITLE: Enhancing early care and education through reflective supervision to promote adaptive emotion regulation in young children

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Mental Health;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative Despite expected exponential increases in Alzheimer’s disease (AD) and related dementias, and an overabundance of research indicating that preoperative cognitive impairment is a major risk factor for negative post-operative outcome, we know very little of AD cognitive, biomarker, and anesthesia/surgical interactions and have little to no evidence-based perioperative medical care strategies for AD patients. Via the K07 mechanism and institutional support, the applicant will leverage novel perioperative clinical and state-of-the-art institutional facilities to develop an institutional wide research and training program addressing these problems. The proposed program will result in improved awareness of cognition and memory status in older adults prior to surgical procedures with anesthesia, intensify collaborative research addressing brain-behavior-anesthesia interactions through both animal and human research approaches, and promote translation of research findings to clinical care.

PI_NAMEs: PRICE, CATHERINE E (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Academic/Teacher Award;Address;Adult;Advisory Committees;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Anesthesia procedures;Anesthesiology;Animal Experimentation;Animals;Awareness;Biological Markers;Blood - brain barrier anatomy;Board Certification;Brain;brain behavior;brain health;Capsicum;Cardiac;Caring;Case Study;Center for Translational Science Activities;certificate program;Clinical;clinical care;Clinical Sciences;Clinical Services;Cognition;Cognitive;cognitive change;cognitive function;cognitive reserve;Collaborations;Colonoscopy;Communities;curriculum development;Data Science Core;Data Sources;Databases;deep learning;Delirium;Dementia;Development;Diagnosis;Disease;Education;Electroencephalography;evidence base;Face;Florida;Funding;Grant;Health;Health system;Healthcare;Healthcare Systems;Human;human old age (65+);Impaired cognition;improved;Individual;Inflammation;Infrastructure;innovation;Institution;Intervention;Investigation;Lead;Leadership;longitudinal human study;Medical;Medicine;meetings;Memory;Mentorship;Methods;mild cognitive impairment;mortality;multidisciplinary;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroimaging;neuroimaging marker;Neurons;Neuropsychology;non-demented;novel;older adult;older patient;Operative Surgical Procedures;Outcome;Parkinson Disease;Pathway interactions;Patients;Pecans;Perioperative;Perioperative Care;Persons;Population;postoperative delirium;Postoperative Period;pre-doctoral;Procedures;programs;prospective;Quality of life;Records;recruit;Replacement Arthroplasty;Research;Research Personnel;research study;Resources;response;Retrospective Studies;Risk;Risk Factors;Science;Scientist;screening;Statistical Models;success;symposium;Thick;Time;Training;Training Programs;Translational Research;trend;United States National Institutes of Health;Universities;Vascular Dementia;Ventricular;White Matter Disease

PROJECT_TITLE: Perioperative Cognitive Anesthesia Network (PeCAN) Program for Alzheimer’s Disease and Related Dementias

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


NIH_SPENDING_CATS: Aging;Arthritis;Assistive Technology;Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Disability Research;Osteoarthritis;Pain Research;Physical Rehabilitation;Rehabilitation

ORG_CITY: Aurora

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE  Osseointegrated prostheses are a novel alternative to a socket that directly mount the prosthesis to the residual limb via a bone anchored implant providing more normative load transmission between the ground and residual limb; yet its effect on the mechanical environment of the joint remains unknown. This project will be the first to rigorously investigate the longitudinal effects of osseointegrated prostheses across multiple biomechanical domains using medical imaging and computational modeling. By quantifying its effect on muscle composition, cartilage loading mechanics, and cartilage health, we can begin to determine if prosthesis osseointegration plays a positive role of osteoarthritis progression in this population differently than a socket, which has vast clinical implications including informing targeted rehabilitation and patient eligibility criteria.

PI_NAMEs: GAFFNEY, BRECCA  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Adopted;Affect;Algorithms;Amputation;Area;arthropathies;articular cartilage;Atrophic;Bilateral;Biochemical;biomechanical model;Biomechanics;Biomedical Engineering;bone;bone health;career;Cartilage;Cartilage Matrix;Case Series;Chronic;Client satisfaction;Clinical;Collagen;Computer Models;Control Groups;Data;Degenerative polyarthritis;design;Development;disability;Disease Progression;Distal;Eligibility Determination;Engineering;Ensure;Environment;Etiology;Fascia;Fatty acid glycerol esters;Femur;Geometry;Goals;Health;hip bone;Hip Osteoarthritis;Hip region structure;Image;Implant;improved;improved outcome;in vivo;Individual;Infiltration;Intervention;joint biomechanics;joint injury;joint loading;Joints;limb amputation;limb loss;Link;Longitudinal Studies;Lower Extremity;Magnetic Resonance Imaging;Maps;mechanical load;Mechanics;Medical Imaging;Mentors;Methodology;Modeling;Motion;Movement;Muscle;Muscle Weakness;Musculoskeletal;novel;Orthopedics;osseointegrated implant;Osseointegration;Outcome;Pathogenesis;Pathologic;Pathology;pathomechanics;patient population;Patients;Pattern;physical therapist;Play;Population;Prosthesis;prosthetic socket;radiologist;Rehabilitation therapy;Relaxation;Reporting;Research;Research Design;residual limb;Role;Secondary pain;Secondary to;skills;Skin;Surgeon;tool;Training;Translating;transmission process;treatment optimization;treatment strategy;Ulcer;Vacuum;Walking;Water

PROJECT_TITLE: Effect of Osseointegrated Prostheses on the Pathogenesis of Hip Osteoarthritis in Patients with Lower Limb Loss


NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Intellectual Disability (ID) and Autism Spectrum Disorders (ASD) are the most common developmental disorders, affecting ~3-4% of children in the U.S. Human genetics studies have revealed that mutations in subunits of the SWI/SNF chromatin remodeling complex are recurrently mutated in individuals with ID/ASD. The proposed study will develop new model systems and experimental tools to study the function of SWI/SNF chromatin remodeling complexes during normal brain development to help understand the specific changes that occur during brain development in children with ID/ASD and to inform development of new therapeutic approaches.

PI_NAMEs: VIERBUCHEN, THOMAS S (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Adopted;Affect;Alleles;ARID1A gene;autism spectrum disorder;Biological Models;Brain;Cell Fate Control;cell fate specification;Cell Proliferation;cell type;Cerebral cortex;chemical genetics;Child;Chromatin Remodeling Factor;Complement;Complex;Data;Defect;Development;developmental disease;Developmental Process;Disease;Dissection;Embryo;Environment;epigenomics;Exhibits;experimental study;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;genetic approach;Genetic study;Genetic Transcription;Genomic approach;Goals;Human Genetics;In Vitro;in vivo;Individual;insight;Intellectual functioning disability;interest;Knowledge;Link;loss of function;loss of function mutation;Loss of Heterozygosity;Measures;Meta-Analysis;Methods;Modeling;Molecular;mouse model;Mus;Mutate;Mutation;Neurodevelopmental Disorder;neurogenesis;Neuronal Differentiation;Neurons;novel;novel therapeutic intervention;novel therapeutics;Nucleosomes;Organoids;Phenocopy;Pluripotent Stem Cells;postmitotic;Predisposition;Prosencephalon;protein degradation;Protocols documentation;rapid technique;Recurrence;Regulatory Element;Reproducibility;Research Personnel;Resolution;Role;single cell ATAC-seq;single cell genomics;stem cell model;temporal measurement;Therapeutic;Time;tool;Transcription Regulatory Protein;transcriptomics

PROJECT_TITLE: Chemical Genetic Dissection of SWI/SNF Chromatin Remodeling Complex Functions in Cerebral Cortex Development

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: The major goals of the Overview are to build upon the leads using cleavage-independent, NFL trimer-liposomes and heterologous prime:boosting that generated bNAbs in a subset of rabbits to translate this remarkable progress at multiple sites of HIV Env vulnerability into non-human primates (NHPs). We propose to use negative stain EM Polyclonal Fab:trimer Epitope Mapping (EMPEM) to better guide boost selection in NHPs from both trimer-liposomes and lipid particle encapsulated mRNA expressing membrane-bound trimers (Projects 1 and Core C, Core B and Projects2) followed by structural analysis of cross-neutralizing antibodies in complex with trimer (Core C), administered by Core A in a multi-faceted approach. The efficient elicitation of tier 2 cross- antibodies in either adult or juvenile NHPs would be a significant step forward toward the goal of generating an effective HIV-1 vaccine to have a substantial impact on improving human public health.

PI_NAMEs: WYATT, RICHARD THOMAS (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: Adolescent;Adult;Affinity;Alleles;Animals;Antibodies;Antibody Formation;Antigens;B cell repertoire;B-Cell Activation;B-Lymphocytes;Binding;Binding Sites;biophysical techniques;Cavia;Cell Separation;Cell surface;Clonal Expansion;Cloning;Collaborations;Complement;Complex;Coupled;Cryoelectron Microscopy;Crystallography;density;design;Encapsulated;Epitope Mapping;Epitopes;Evaluation;Evolution;experimental study;follow-up;Frequencies;Germ Lines;glycosylation;Goals;HIV;HIV Envelope Protein gp120;HIV-1 vaccine;Human;Immune;Immune response;Immunity;Immunization;Immunodominant Epitopes;Immunoglobulin G;improved;In Vitro;in vivo;Infection;Link;lipid nanoparticle;Lipids;Liposomes;lymph nodes;Macaca;Masks;Membrane;Memory B-Lymphocyte;Messenger RNA;Methods;Modification;Molecular Sieve Chromatography;Monoclonal Antibodies;mRNA Expression;Negative Staining;neutralizing antibody;neutralizing monoclonal antibodies;neutralizing vaccine;nonhuman primate;novel;Oryctolagus cuniculus;Outcome;particle;Particulate;Penetration;Peptides;Polysaccharides;Process;Property;Public Health;Publications;Resolution;response;screening;Serum;Site;Specific qualifier value;Specificity;Structure;success;Tail;Technology;Time;Tissues;Translating;Vaccination;vaccine candidate;vaccine development;Viral;ward;working group

PROJECT_TITLE: Eliciting neutralizing antibodies and B cell responses using novel HIV Env immunogens in non-human primates


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Diabetes;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Kidney Disease;Lung;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project narrative: This proposal will study the effect of cytokine storm, released during COVID-19 infection, in worsening pre- existing glomerular disease in animal models of focal segmental glomerulosclerosis and diabetic nephropathy, with the goal of developing novel therapeutic strategy.

PI_NAMEs: MACE, CAMILLE EMILIE ADELINE (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: 2019-nCoV;Acute;acute liver injury;Acute Renal Failure with Renal Papillary Necrosis;Adriamycin PFS;Albuminuria;Animal Model;Antibodies;chemokine;Chronic Kidney Failure;Clinical Research;Complex;COVID-19;COVID-19 complications;COVID-19 cytokine storm;COVID-19 diagnosis;COVID-19 impact;COVID-19 patient;COVID-19 risk;COVID-19 treatment;Creatinine;CXCL5 gene;cytokine;cytokine release syndrome;Data;db/db mouse;Diabetes Mellitus;Diabetic Nephropathy;diabetic rat;Disease;Disease Outcome;Dose;Endothelium;Focal and Segmental Glomerulosclerosis;Goals;Heart Injuries;Histology;Hospitalization;Human;Hypersensitivity;IL-13Ralpha1;IL8RB gene;improved;improved outcome;Infection;Inflammatory;Injections;Injury;Injury to Kidney;Interleukin-13;Interleukin-4;Kidney;Kidney Diseases;Knock-out;Mediating;Modeling;Morphology;mortality;Mus;novel therapeutic intervention;Obesity;older patient;pandemic disease;Pathway interactions;Patients;Persons;Plasma;podocyte;post SARS-CoV-2 infection;prevent;Proteins;Proteinuria;Rattus;receptor;Renal function;Renal glomerular disease;Respiratory Tract Infections;Risk Factors;Rodent;Role;SARS-CoV-2 infection;Sepsis;Serum;severe COVID-19;Signal Pathway;System;Systemic disease;Therapeutic;TNF gene;TNFRSF1A gene;tumor;Vascular Endothelial Growth Factors;World Health Organization

PROJECT_TITLE: Covid-19 induced worsening of glomerular diseases

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Data Science;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Networking and Information Technology R&D (NITRD);Substance Misuse

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Narrative The purpose of the HIV and Substance Use Cohort Coordinating Center for Emerging and High Impact Scientific Cross Cohort Studies: HIV SUCCESS for the HIV/AIDS and Substance Use Cohorts Program is to coordinate and support a collaboration of longitudinal cohorts to address emerging and high priority research in the setting of substance use and HIV. We are well-positioned to provide operational support for cohorts and a platform for harmonizing data to address important research questions as we supply infrastructure and resources matched with innovative methodological approaches, scientific leadership including substance use and HIV research expertise, administrative support for protocol development, implementation and dissemination, development of future HIV and substance use research through mentorship, and most importantly a multi-disciplinary team with expertise in substance use treatment and research, clinical HIV, data integration, substance use intervention implementation, epidemiology, biostatistics, and clinical informatics. As the HIV SUCCESS coordinating center, we will bring our vast experience with cohort collaborations such as CNICS, STTR, ROI, ARCH, and NA-ACCORD and with harmonizing HIV data across cohorts which will allow us to generate new knowledge at the intersection of HIV and substance use to inform future research and clinical care in the US.

PI_NAMEs: CHANDER, GEETANJALI ;CRANE, HEIDI M. (contact);DELANEY, JOSEPH AUSTIN;DRUMRIGHT, LYDIA NICOLE

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Abbreviations;Acceleration;Acquired Immunodeficiency Syndrome;Address;Adherence;adjudication;Aging;American;antiretroviral therapy;Area;Award;Biological Markers;Biological Specimen Banks;Biometry;Caring;Clinical;clinical care;clinical epidemiology;Clinical Informatics;clinical research site;Code;cohort;Cohort Studies;Collaborations;Communities;comorbidity;Complex;COVID-19 risk;Data;Data Analyses;Data Collection;data harmonization;data integration;Data Linkages;data management;data platform;data repository;Data Science;Data Sources;data tools;design;Development;Disparate;Disparity;Dissemination and Implementation;Documentation;Drug usage;Ensure;Epidemic;Epidemiologist;Epidemiology;Evaluation;experience;Funding;Future;Future Generations;Generations;Genetic;Health;health data;HIV;HIV/AIDS;implementation intervention;improved;Individual;informatics infrastructure;Infrastructure;Infusion procedures;innovation;Intervention;Knowledge;Leadership;Learning;Link;Longitudinal cohort;Mentors;Mentorship;Methamphetamine;method development;Methodology;Molecular Epidemiology;multidisciplinary;National Institute of Drug Abuse;North America;Opioid;opioid epidemic;opioid use;Outcome;Patient Outcomes Assessments;Pattern;Persons;Population;Population Heterogeneity;Positioning Attribute;pre-exposure prophylaxis;Prevalence;programs;protocol development;Provider;Public Health;Public Health Informatics;Publications;Publishing;Regimen;Research;Research Personnel;Research Priority;Resources;Risk;Risk Factors;Running;Rural;Scientist;Site;social health determinants;spelling;Statistical Methods;Stimulant;Subgroup;substance use;substance use treatment;syndemic;System;Target Populations;Testing;tool;tool development;Training;Translations;transmission process;United States;uptake;web site;Work;working group


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Endocannabinoid System Research;Mental Health;Mental Illness;Neurosciences;Physical Activity;Post-Traumatic Stress Disorder (PTSD);Therapeutic Cannabinoid Research

ORG_CITY: TUSCALOOSA

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

ORG_STATE: AL

PHR: PROJECT NARRATIVE The goal of the current project is to use advanced cognitive, physiological, and neuroimaging techniques to critically evaluate whether aerobic exercise boosts fear extinction learning processes and thus, reduces subsequent fear responding (when tested 24hrs later) in trauma-exposed adult men and women with and without Posttraumatic Stress Disorder (PTSD). This research has the potential to inform the neurobiological mechanisms responsible for reducing the return of fear in adults with PTSD, and thereby could lead to improved treatment approaches for the millions of Americans currently diagnosed with PTSD.

PI_NAMEs: CROMBIE, KEVIN M (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Adult;Aerobic Exercise;Agonist;American;Amygdaloid structure;anandamide;Animal Model;Anxiety Disorders;anxiety reduction;Biometry;career development;Clinical;clinical anxiety;Clinical Psychology;Clinical Trials;Cognitive;cognitive enhancement;Collaborations;computational neuroscience;Computer Models;Control Groups;Dangerousness;Data;design;Diagnosis;Disease remission;Dose;Endocannabinoids;endogenous cannabinoid system;Enzymes;Exercise;exercise intensity;Exhibits;Expectancy;experience;Extinction;FAAH inhibitor;fatty acid amide hydrolase;Fostering;Fright;Functional Magnetic Resonance Imaging;Galvanic Skin Response;Goals;Hippocampus;Image;improved;indexing;Individual;Interdisciplinary Study;International;Knowledge;Laboratories;Laboratory Study;Learning;learning extinction;lens;Light;Mediating;Memory;memory consolidation;memory encoding;men;Mental Health;Mentored Research Scientist Development Award;Mentorship;Methodology;Modeling;multidisciplinary;neural;neural circuit;neural patterning;neurobiological mechanism;neuroimaging;notch protein;Outcome;Participant;Pathway interactions;Pattern;Peripheral;pharmacologic;Pharmacology;Physiological;Pilot Projects;Population;Post-Traumatic Stress Disorders;Prefrontal Cortex;Process;Psychiatry;Psychophysiology;Psychotherapy;Randomized;Regulation;Research;Research Personnel;response;Retrieval;Role;Safety;Sampling;scaffold;Signal Transduction;Techniques;Testing;Texas;theories;Therapeutic;Training;Trauma;trauma exposure;Treatment Efficacy;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: The influence of aerobic exercise on consolidation of fear extinction learning in PTSD


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: FARGO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTH DAKOTA STATE UNIVERSITY

ORG_STATE: ND

PHR: The prevalence rate of asthma is higher in pre-pubescent and aging males, and in post-pubertal females, suggesting a role for female sex steroids such as estrogens in modulating this disease. However, studies suggest a possible role of other signaling mechanisms interplaying with estrogens. Kisspeptin is a crucial regulatory protein involved in female puberty as well as a modulator of sex steroids. In this context, we propose that a decrease in expression of kisspeptin and their function in asthmatics compared to non-asthmatics (specifically females) conveys a possible sex specific role of kisspeptin in asthma. Our studies use human airway smooth muscles from both male and female asthmatics vs. non-asthmatics, along with animal studies where we control estrogen levels. These studies will substantially enhance our understanding of how and why kisspeptin signaling influences the asthmatic airway. This is a necessary and clinically important step if we are to develop novel therapeutic strategies for asthma, possibly in a gender/sex specific fashion.

PI_NAMEs: VENKATACHALEM, SATHISH  (contact)

PROJECT_TERMS: Aging;Agonist;airway hyperresponsiveness;airway remodeling;Allergens;Animals;Asthma;asthma model;asthmatic;asthmatic airway;asthmatic airway smooth muscle;autocrine;Biology;Bronchodilation;cancer cell;Cell Proliferation;cell type;Cells;Clinical;clinically significant;cytokine;Data;Disease;Elements;epidemiologic data;Epithelium;Estradiol;Estrogens;Extracellular Matrix;Extrinsic asthma;Female;Fibroblasts;Fibrosis;G-Protein-Coupled Receptors;Gender;genetic regulatory protein;GNRH1 gene;Goals;Gonadal Steroid Hormones;Gonadotropins;Human;Immunofluorescence Immunologic;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inhibition of Cell Proliferation;inhibitor;KISS1 gene;KISS1R gene;Knockout Mice;laser capture microdissection;Lung;male;MAP Kinase Gene;migration;Modeling;Molecular;mouse allergen;mouse model;Mus;Muscle;Muscle function;muscular structure;Neoplasm Metastasis;novel;novel therapeutic intervention;Ovariectomy;p38 Mitogen Activated Protein Kinase;Peptides;Physiological;Play;Prevalence;Production;Proliferating;protective effect;protective pathway;Proteins;Puberty;receptor;Resistance;respiratory smooth muscle;Role;sex;Signal Transduction;Slice;Smooth Muscle Myocytes;Source;Structure;System;Trifluoroacetate;Uncertainty;Woman;Women's Role

PROJECT_TITLE: Kisspeptins in the Airway

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-N(03)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Mental Health;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The hypomorphic E4 allele of APOE is the strongest genetic risk for Alzheimer's Disease, yet it is unclear how it contributes to AD etiology. We propose to investigate the molecular consequences of APOE deficiency on the HPA axis and their interaction on learning and memory.

PI_NAMEs: LEE, RICHARD S;TAMASHIRO, KELLIE L. K. (contact)

PROJECT_TERMS: Acute;acute stress;Age;Age Months;Aging;Alleles;allostasis;allostatic load;Alzheimer's Disease;Alzheimer's disease risk;Animal Model;Animals;antagonist;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Apolipoproteins;Atherosclerosis;behavior test;biological adaptation to stress;Biology;Blood;Brain region;brain volume;burden of chronic illness;burden of illness;Cardiovascular system;Cells;Cholesterol;Chronic;Chronic stress;Cognition;Cognitive deficits;cohort;Corticosterone;CRISPR/Cas technology;Custom;Dementia;design;differential expression;Disproportionately impacts women;DNA Methylation;DNA methylation profiling;environmental stressor;Epigenetic Process;Etiology;Exhibits;Exposure to;Failure;Female;fighting;FK506 binding protein 5;Functional disorder;gene editing technology;Gene Expression Profile;gene function;Genes;Genetic Risk;genetic risk factor;genetic signature;Genetic Transcription;Genotype;Glucocorticoid Receptor;Glucocorticoids;Hippocampus;Homeostasis;hormonal signals;Hormones;Human;Hydrocortisone;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Impaired cognition;Impairment;Individual;inhibitor;insight;Knock-out;Knockout Mice;Late Onset Alzheimer Disease;Lead;Learning;Linear Regressions;Link;lipid metabolism;lipid transport;Lipids;male;Measures;Mediating;Memory;Mental disorders;Methylation;Modeling;Modification;Molecular;Mus;Neuroglia;Neurons;novel therapeutic intervention;NR3C1 gene;older adult;pharmacologic;Plasma;Play;Predisposition;Prevalence;Prevention;protective allele;Proteins;Reporting;response;risk variant;Role;Sampling;segregation;sex;Signal Transduction;Stress;stressor;Symptoms;Testing;tool;transcriptome sequencing;young adult

PROJECT_TITLE: Impact of APOE deficiency on HPA axis function and cognition

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Rheumatoid Arthritis

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Despite advances in understanding the immuno-pathogenesis of RA, disability remains high due to persistent inflammation and joint damage from increased osteoclast (OC)-mediated bone erosion and decreased osteoblast (OB)-mediated bone formation. Remissions are rare. We will evaluate how a novel subset of B cells, expressing the transcription factor T-bet, contribute to ongoing disease activity and inhibit bone-forming OBs and activate bone-eroding OCs, thus contributing to inflammation and joint destruction. This research is important because a better understanding of disease pathogenesis will ultimately lead to new therapies and allow patient- tailored treatment strategies.

PI_NAMEs: ANOLIK, JENNIFER HOWITT (contact);XING, LIANPING

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Abnormal Cell;Acceleration;Affect;aggressive therapy;Animal Model;Arthritis;arthropathies;Automobile Driving;autoreactivity;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;Blood;bone;bone erosion;CCL3 gene;cell injury;Cell Lineage;cell motility;Cell Physiology;Cells;chemokine;chemokine receptor;Chronic;Clinical;clinical remission;Coculture Techniques;cohort;Cohort Studies;Collagen Arthritis;CXC chemokine receptor 3;CXCL9 gene;CXCR3 gene;cytokine;Data;defined contribution;disability;Disease;Disease remission;Effector Cell;Family member;Future;Genetic Transcription;Genomic approach;Goals;Immune;improved outcome;In Vitro;individualized medicine;Inflammation;Inflammatory;Inflammatory Response;innovation;Interferons;joint destruction;joint inflammation;joint injury;Joints;Kinetics;Knock-out;Knockout Mice;Knowledge;Ligands;Link;Location;Longitudinal cohort;Lupus;Mediating;Medicine;migration;Modeling;monocyte;Morbidity - disease rate;mortality;Mus;novel;novel therapeutics;Osteoblasts;Osteoclasts;Osteogenesis;Pathogenesis;Pathogenicity;Patients;Phenotype;Population;pre-clinical;preclinical study;prevent;Production;programs;Regulation;Reporter;Reporting;Research;Resolution;response;Rheumatoid Arthritis;Role;role model;Severity of illness;single-cell RNA sequencing;SLAM protein;Synovial Membrane;Synovitis;Systemic Lupus Erythematosus;T-bet protein;T-Lymphocyte;Therapeutic;Time;Tissues;TNF gene;TNFSF11 gene;transcriptomics;translational study;treatment strategy;United States National Institutes of Health;Virulence Factors;virulence gene

PROJECT_TITLE: Role of T-bet B cells in  rheumatoid  arthritis

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: PA

PHR: Traumatic brain injury (TBI) affects more than 2.5 million (US civilian and veterans) annually and accounts for 30% of all injury-related fatalities, with ~75% of these categorized as mild TBI (mTBI) or concussion. Repetitive mTBI injuries induce cumulative adverse effects which may continue for many years after the original injury, with trauma representing one of the strongest environmental risk factors for developing neurodegenerative disorders. This proposal will investigate the underlying mechanisms and explore therapeutic strategies for treating repetitive mTBI.

PI_NAMEs: SUN, DANDAN  (contact)

PROJECT_TERMS: Actins;Adverse effects;Affect;Alzheimer's Disease;Amyloid beta-Protein Precursor;Astrocytes;astrogliosis;Attenuated;axon injury;Axonal Transport;Behavioral;Brain;brain cell;Brain Concussion;Brain Injuries;Categories;Clinical Research;cofilin;Cognitive;cognitive function;Complex;contact sports;controlled cortical impact;Corpus Callosum;cranium;cytokine;Data;effective therapy;Environmental Risk Factor;Enzyme-Linked Immunosorbent Assay;Event;Flow Cytometry;functional decline;Gene Deletion;Gene Expression Profile;Gliosis;Hippocampus;Immunofluorescence Immunologic;Impaired cognition;Impairment;improved;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;Interruption;Knowledge;Mediating;Microglia;mild traumatic brain injury;Military Personnel;Modeling;Molecular;Motor;mouse model;Mus;Myelin Sheath;NADPH Oxidase;Nervous System Physiology;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurologic;Neurons;new therapeutic target;Oligodendroglia;Oxidative Stress;Pathogenesis;Pathologic;pharmacologic;Play;Production;protein activation;protein function;Protein Isoforms;Proteins;Reactive Oxygen Species;Recovery of Function;Rod;Role;Stains;TBI Patients;Therapeutic;Time;Trauma;Traumatic Brain Injury;United States;Up-Regulation;Veterans;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Identify Novel Therapeutic Targets for Repetitive Mild TBI

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURC-H (01)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: NARRATIVE. Pregnant females with severe obesity are more likely to experience adverse perinatal health events including gestational diabetes, preeclampsia and preterm labor as well as birth babies with discordant growth patterns. Rigorous interventions targeting gestational weight gain and dietary quality have not translated to markedly improved perinatal health among this population suggesting a need for innovation. This pilot study aims to test the safety, acceptability and preliminary efficacy of time-restricted eating on weight, cardiometabolic risk markers and perinatal health outcomes among pregnant Black females given they suffer disproportionately from both severe obesity and adverse health events in the perinatal period.

PI_NAMEs: KOENIG, MARY DAWN ;TUSSING-HUMPHREYS, LISA  (contact);VARADY, KRISTA AMY

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: 37 weeks gestation;Acceleration;acceptability and feasibility;Adherence;Admission activity;Adoption;adult obesity;Adverse event;Affect;Age;arm;Birth;Black race;black women;Blood Glucose;Blood Pressure;Body fat;Body mass index;Body Weight;C-reactive protein;Caloric Restriction;Calories;cardiometabolic risk;Cesarean section;Clinic;Clinical;Clinical Data;Clinical Trials;Congenital Abnormality;Consumption;Data;Data Collection;Diet;dietary;Dietary Practices;Disease;Eating;efficacy trial;Electronic Health Record;Eligibility Determination;Enrollment;Ethnic Origin;Event;excessive weight gain;Fasting;Female;fetal;Fetal Death;Fetal Growth;Fetal health;Financial Hardship;Food;food restriction;food surveillance;Funding;Gestational Age;Gestational Diabetes;gestational weight gain;Glucose;Goals;Growth;Health;Health Food;High Prevalence;Hispanic Women;improved;Individual;innovation;Insulin;interest;Intermittent fasting;Intervention;Intervention Studies;Interview;Isoprostanes;lifestyle intervention;Lipids;Maternal Health;Maternal Mortality;maternal risk;Medical;meetings;member;Metabolic;Mission;Monitor;Morbid Obesity;National Institute of Diabetes and Digestive and Kidney Diseases;neonatal health;Not Hispanic or Latino;Nutritionist;Obesity;Observational Study;Outcome;Oxidative Stress;Participant;Patients;Pattern;Perinatal;perinatal health;perinatal outcomes;perinatal period;Personal Satisfaction;Persons;Physical activity;Pilot Projects;Population;Pre-Eclampsia;Pregnancy;pregnancy hypertension;pregnant;Premature Birth;Premature Labor;Prenatal care;prevent;programs;Public Health;Race;Regimen;reproductive;Research;Research Infrastructure;response;Risk;Risk Marker;Safety;safety testing;Second Pregnancy Trimester;standard care;Subgroup;Third Pregnancy Trimester;Time-restricted feeding;Translating;United States;United States National Institutes of Health;Veins;Visit;Weight;weight maintenance;Weight maintenance regimen;White Women;Work

PROJECT_TITLE: A pilot study of time-restricted eating among pregnant females with severe obesity

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Immunologic memory, by which the immune system “remembers” previous exposures to pathogens by responding faster and better, is critical to health, including vaccination responses. After initial exposure to a pathogen, some B lymphocytes that can make antibodies also change to become longer-lived and to respond differently than they did originally, becoming “memory B cells”. We are trying to understand the molecular basis of these changes and the types of memory B cells that are generated, which will in turn help understand resistance to pathogens, vaccine responses, and possibly some autoimmune diseases.

PI_NAMEs: SHLOMCHIK, MARK J (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Address;Aging;Antibodies;Antigens;Autoimmune Diseases;Autoimmunity;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;Biological Models;Cell Count;Cell Physiology;Cells;Chromatin;Data;Databases;Development;differential expression;Elements;Engineering;epigenetic memory;Epigenetic Process;exhaustion;Exposure to;Gene Expression;gene regulatory network;Generations;Genes;genetic approach;Genetic Engineering;genome-wide;Health;Heterogeneity;Human;Humoral Immunities;Immune;Immune response;Immune system;Immunization;Immunologic Memory;imprint;in vivo;inducible Cre;Infection;LoxP-flanked allele;Maps;member;Memory;Memory B-Lymphocyte;Molecular;Mus;Mutation;Natural regeneration;pathogen;pathogen exposure;Pathway interactions;Phase;Phenotype;Positioning Attribute;precursor cell;prevent;Process;programs;Property;Recurrence;Resistance;response;Rest;Role;Signal Transduction;Specificity;stem;stem-like cell;Surface;System;T memory cell;Testing;Time;tool;Vaccination;Vaccine Design;vaccine efficacy;vaccine response;Vaccines;Work

PROJECT_TITLE: Murine Memory B cell Development and Function

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Current retinal prostheses for treating blindness caused by photoreceptor degeneration lack the necessary spatial resolution to provide high acuity vision. Intraretinal stimulation achieved by ultrasmall carbon fiber electrodes can elicit responses from single retinal ganglion cells without inadvertently activating nearby axons. The project will investigate basic mechanisms of intraretinal stimulation, optimize stimulation parameters, and assess functionality and biocompatiblity of an intraretinal stimulation array in a large-eye animal model.

PI_NAMEs: WEILAND, JAMES D. (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Age related macular degeneration;Algorithms;Animal Model;Animals;Autopsy;Axon;biomaterial compatibility;biophysical model;Blindness;carbon fiber;Cells;Charge;Choroid;Chronic;Cicatrix;Clinical;Clinical Research;Compensation;cost;density;design;Devices;Diameter;Effectiveness;Electric Stimulation;Electrodes;Electronics;Engineering;Eye;Fiber;Goals;Image;Immunohistochemistry;Implant;implantation;improved;Individual;Inner Nuclear Layer;innovation;Iridium;Legal Blindness;legally blind;Measurement;Measures;meter;Miniature Swine;Modeling;Mus;neural;Neurobiology;neurosurgery;neurotechnology;novel;Operative Surgical Procedures;Optical Coherence Tomography;Patients;Pattern;Peripheral;Persons;photoreceptor degeneration;Photoreceptors;Physiologic pulse;Physiological;Platinum;Positioning Attribute;Prosthesis;Quality of life;receptive field;Reporting;Research;Resolution;response;Retina;Retinal Degeneration;Retinal Detachment;Retinal Ganglion Cells;retinal neuron;retinal prosthesis;retinal stimulation;Retinitis Pigmentosa;scaffold;Shapes;Site;Specificity;Stimulus;Surface;Surgical complication;System;Technology;Testing;Time;time use;Tissues;Update;Variant;Vision;Visual Acuity;Visual Fields;Visual Perception;Whole-Cell Recordings;Work

PROJECT_TITLE: Intraretinal stimulation for high acuity artificial vision

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Depression;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: Narrative The continuing need for additional therapeutic drugs to treat mental health disorders involving monoamine signaling provides a compelling reason to further our understanding of how monoamine signaling is regulated. In this proposal we intend to employ novel transporter interacting molecules and identify structural elements within the dopamine transporters that determine transporter function and regulation. This will enable a systematic evaluation of the therapeutic potential of these activities in preclinical animal models for a broad spectrum of disorders involving aberrant monoaminergic signaling including ADHD, depression, anxiety, schizophrenia and drug and alcohol abuse.

PI_NAMEs: MORTENSEN, OLE VALENTE (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: abuse liability;Addictive Behavior;Address;Adopted;Affect;Alcohol abuse;Allosteric Site;Amphetamines;analog;Animal Behavior;Animal Model;Animals;Anxiety;Attention deficit hyperactivity disorder;Attenuated;Behavior;Behavioral;behavioral study;Bilateral;Binding;Binding Sites;Biochemical;Brain Diseases;Cell membrane;Clinical;Cocaine;cocaine prevention;Computer Models;Computer Simulation;computer studies;conditioning;Coupled;Data;design;Development;Disease;Dopamine;dopamine transporter;dopaminergic neuron;Dose;Drug abuse;drug candidate;drug of abuse;Elements;Evaluation;Event;Exclusion;experimental study;extracellular;Family;Functional disorder;Goals;improved;in vivo;Knowledge;Learning;Ligands;Locomotion;Mediating;Mental Depression;Mental disorders;Methods;Modeling;Molecular;monoamine;Nervous System Disorder;Neurologic;neurotransmission;Neurotransmitters;noradrenaline transporter;Norepinephrine;novel;novel strategies;novel therapeutics;Nucleus Accumbens;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;pharmacophore;Phenotype;pre-clinical;Property;Proteins;psychostimulant;Rattus;Regulation;reuptake;Rewards;Rodent;Role;Schizophrenia;Selective Serotonin Reuptake Inhibitor;Serotonin;serotonin transporter;Signal Transduction;simulation;Site;small molecule;stimulant use;stimulant use disorder;Structure;Synapses;Therapeutic;therapeutic candidate;therapeutic evaluation;Therapeutic Studies;tool;Transport Process

PROJECT_TITLE: Regulating dopamine transport through allosteric modulation - Functional and Behavioral Studies

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: TUCSON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: This work will clarify a critical control mechanism that maintains synaptic structure and function. The protein we are investigating is directly impaired in a poorly understood pediatric nervous system disorder. Our project will determine the underlying causes of disruption at the biochemical, cellular, and functional levels, which will ultimately inform how we might correct the neurological deficits in patients.

PI_NAMEs: BHATTACHARYA, MARTHA RUTH CHASE (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Affect;Amino Acids;Behavior;behavioral phenotyping;Bile Acids;Biochemical;Biological Assay;Catabolism;Cells;Cellular Assay;Childhood;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;Corpus Callosum;Data;Defect;Development;Diagnosis;Disease;Drosophila genus;Electrophysiology (science);endosome membrane;Endosomes;Ensure;Epilepsy;Etiology;fly;FRAP1 gene;Genes;Genetic;Glutamates;Goals;Growth;Human;human disease;human model;Hyperactivity;Impairment;improved;in silico;in vivo;in vivo evaluation;insight;Intellectual functioning disability;Intracellular Membranes;Knowledge;Life;Link;lipidomics;Lipids;Maintenance;malformation;Mediating;Membrane Proteins;Microcephaly;Modeling;Molecular;Morphology;Mus;Mutant Strains Mice;Mutation;Nerve;Nervous System;Nervous System Disorder;neurodevelopment;Neurologic;Neurologic Deficit;Neuromuscular Junction;neuronal growth;Neuronal Plasticity;Neurons;novel;Pathway interactions;Patients;Phenotype;phosphoproteomics;Process;protein structure;Proteins;Proteomics;Publishing;Regulation;restoration;Role;Signal Pathway;Signal Transduction;Sterols;Structure;Swelling;Synapses;Synaptic Transmission;Synaptic Vesicles;synaptogenesis;Syndrome;Testing;Thermodynamics;thermostability;tool;tumor;Variant;Work

PROJECT_TITLE: Establishing the Function of TMEM184B in mTORC1 Regulation and Synaptic Maintenance

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Liver Disease

ORG_CITY: CLEVELAND

ORG_DEPT: SURGERY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Over 80% of patients with metastatic colorectal cancer (mCRC) develop metastases in the liver and have worse outcomes than those with primary tumors. This proposal focuses on determining the role of liver endothelium-secreted LRG1 in promoting mCRC tumorigenesis, and elucidating the involved mechanisms. This project will identify a new signaling pathway by which the liver endothelium microenvironment promotes mCRC development and will identify potential targets for developing new therapies to treat patients with mCRC.

PI_NAMEs: WANG, RUI  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Affinity;angiogenesis;Archives;Attenuated;Award;Binding;Binding Proteins;Biological Assay;cancer cell;Cancer Cell Growth;cancer initiation;Cancer Model;cancer type;career;Cell Physiology;Cell secretion;Clinical Data;clinically relevant;colon cancer patients;Colorectal Cancer;colorectal cancer metastasis;colorectal cancer progression;Data;Development;Dimerization;Endothelial Cells;Endothelium;Epidermal Growth Factor Receptor;ERBB3 gene;Foundations;Glycoproteins;Goals;Growth;Human;Implant;Injections;innovation;Kinetics;Knock-out;Knockout Mice;Leucine;Ligands;Liver;Mediating;Mediator;metastatic colorectal;Metastatic Neoplasm to the Liver;Mus;Neoplasm Metastasis;Neuregulins;neutralizing antibody;novel;novel therapeutic intervention;novel therapeutics;Null Lymphocytes;Organoids;Outcome;PAR-2 Receptor;paracrine;patient biomarkers;patient derived xenograft model;Patient-Focused Outcomes;Patients;Phosphorylation;Phosphotransferases;Play;Primary Neoplasm;Prognostic Marker;Protein Binding Domain;Protein Tyrosine Kinase;Proteomics;Role;Sampling;Signal Pathway;Signal Transduction;Site;Stromal Cells;subcutaneous;survival outcome;Survival Rate;targeted treatment;Testing;Time;transcriptomics;Treatment Failure;tumor;tumor growth;Tumor Promotion;tumorigenesis;Vascular remodeling;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Role of LRG1 in colorectal cancer tumorigenesis

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative Understanding of how H2-O, a non-classical Major Histocompatibility Class II (MHCII)-like molecule, H2-O, negatively regulates MHCII antigen presentation will undoubtedly improve current vaccination protocols and may facilitate vaccination against pathogens for which vaccines are not currently available.

PI_NAMEs: GOLOVKINA, TATYANA V (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immune response;Affinity;Alleles;Amino Acid Substitution;Animals;Antibodies;Antibody Response;Antigen Presentation;Antigen Presentation Pathway;Antigen-Presenting Cells;antiviral immunity;Apolipoproteins;Binding;Biochemical;Bioinformatics;Bone Morphogenetic Proteins;C57BL/6N Mouse;CD4 Positive T Lymphocytes;Cells;Development;fodrin;gain of function;Genes;Genetic;Hepatitis B;Hepatitis C;Histocompatibility;Histocompatibility Antigens Class II;Homologous Gene;Human;I/LnJ Mouse;Immune response;Immunoglobulin Domain;improved;in vivo;Infection;Inherited;insight;Knowledge;Lead;Link;loss of function;mammary tumor virus;Mediating;Membrane;Mouse Mammary Tumor Virus;Murine leukemia virus;Mus;mutant;Mutant Strains Mice;neutralizing antibody;novel;Outcome;pathogen;Pathway interactions;Peptides;positional cloning;Predisposition;Process;Production;Proteins;receptor;Recessive Genes;Regulation;Resistance;response;Retroviridae;Role;United States National Institutes of Health;Vaccination;vaccination protocol;Vaccines;vacuolar H+-ATPase;Variant;Viral;viral resistance;Virus;Virus Diseases

PROJECT_TITLE: Retroviral infection and new modulators of the MHCII pathway

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Mental Health;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

ORG_CITY: NEW HAVEN

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Agitation frequently occurs when patients experience mental health crises, and use of invasive measures like physical restraints to manage agitation are disproportionately used on racial/ethnic minorities and socioeconomically disadvantaged individuals in the emergency setting. This study will use system dynamics modeling, a rigorous simulation modeling and systems science method, to describe, measure, and reduce disparities in agitation care by developing mental health interventions and assessing their potential benefits and costs on key equity outcomes through partnerships with patients, clinicians, and healthcare administrators.

PI_NAMEs: HECKMANN, REBEKAH ;WONG, AMBROSE H (contact)

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Accident and Emergency department;Address;Administrator;Aggressive behavior;Agitation;Apnea;Area;Arousal;assault;Attitude;Behavior;Behavioral;black patient;Black race;burnout;Calibration;Caring;Cessation of life;Chemicals;community based participatory approach;Complex;Computer Simulation;Costs and Benefits;Cross-Sectional Studies;Crowding;Data;Data Set;Decision Making;design;Development;Differential Equation;Discrimination;Disparate;Disparity;Disparity population;disparity reduction;dynamic system;Economically Deprived Population;Electronic Health Record;Emergency Care;emergency settings;Ensure;Environment;Equation;Equity;ethnic minority;Event;experience;Exposure disparity;Feedback;Focus Groups;Fright;Frontline worker;Future;Goals;Health;health care disparity;health disparity;health equity;health equity promotion;Health Personnel;health record;Healthcare;heuristics;Homelessness;hospital services;Hospitals;improved;Individual;Injury;innovation;insight;Insurance;Intervention;Knowledge;Leadership;lens;Link;Literature;low socioeconomic status;marginalization;marginalized population;mathematical model;Mathematics;Measures;member;Mental Health;Methodology;Methods;Minority;Minority Groups;minority patient;model building;Modeling;models and simulation;Negative Reinforcements;Outcome;Patient advocacy;patient safety;Patient-Focused Outcomes;Patients;Physical Restraint;Police;Policies;Population;Population Group;Population Heterogeneity;Prevalence;Process;prospective;prototype;psychiatric emergency;public health insurance;racial minority;Records;recruit;Reduce health disparities;Research;Resources;response;restraint;Risk;Safety;Science;Security;sedative;Series;severe mental illness;simulation;Site;socioeconomic disadvantage;Stress;Structure;Study models;Substance Use Disorder;Surveys;System;Techniques;Testing;Time;tool;Translating;Trauma;trend;Underserved Population;Validation;Violence;Visit;web based interface;Work;worker safety;Workplace;workplace violence

PROJECT_TITLE: System Dynamics Modeling to Promote Health Equity in Management of Agitation

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Opioids;Pain Research;Substance Misuse

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: PROJECT NARRATIVE Medical marijuana use among adults 50 and older has more than doubled in the past decade with exponential increases projected in this demographic by 2050, and prescription opioids are one of the most common treatments for pain management in this population. The current proposal seeks to examine effects of daily medical marijuana use for 12 months or greater and the combined effect of prescription opioid use to identify whether medical marijuana and/or prescription opioid use affects performance on an open-road driving task in adults 50 and older who endorse chronic or severe non-malignant pain.

PI_NAMEs: CLASSEN, SHERRILENE ;ENNIS, NICOLE  (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Adult;Affect;Age;aged;Aging;Automobile Driving;Cannabis policy;Chronic;chronic pain;chronic pain management;Classification;Cognitive;common treatment;Computerized Medical Record;Data;Devices;disability;District of Columbia;driving performance;driving under influence;Explosion;Florida;Flowers;Goals;Guidelines;Health;improved;Informal Social Control;Inhalators;International;Intervention;Legal;Long-Term Effects;Marijuana;marijuana use;marijuana user;Matched Group;Measures;Medical;medical examination;Medical Marijuana;milligram;Modeling;Motor;National Institute of Drug Abuse;Non-Malignant;Opioid;opioid use;Outcome;Pain;Pain management;Participant;Patients;Performance;Population;prescription opioid;primary outcome;Proliferating;prospective;Race;Recording of previous events;recruit;Research;Research Infrastructure;Risk;screening;sex;social;standardize measure;Sum;Target Populations;Task Performances;Testing;Tetrahydrocannabinol;THC exposure;theories;Time;Urinalysis;Urine;Vehicle crash;Work;young adult

PROJECT_TITLE: An open road driving performance task to examine long-term medical marijuana use and prescription opioid positivity in adults 50 and older

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-Y (02)]


NIH_SPENDING_CATS: Infectious Diseases;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Women's Health Research

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE Adverse morbidity Streptococcus inflammation  pregnancy outcomes, including premature birth and stillbirth, are the leading causes of neonatal and mortality. A frequent cause is Intrauterine infection, which occurs when bacteria like Group B (GBS) ascend from the vagina into the uterus and invade the amniotic cavity, leading to and tissue damage. As maternal GBS colonization of the female genital tract (FGT) represents the major risk factor for adverse pregnancy outcomes my research seeks to elucidate the molecular mechanisms that govern the dynamic aspects of GBS vaginal carriage and ascension to the FGT.

PI_NAMEs: DORAN, KELLY S (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Acute suppurative arthritis due to bacteria;Address;Adherence;Adult;adverse pregnancy outcome;amniotic cavity;antagonist;anti-toxin;Antigens;aspirate;Bacteria;Bacterial Adhesins;Bioinformatics;Birth;Cell Communication;Cells;commensal microbes;Complex;Contracts;Development;Diabetes Mellitus;Disease;Elderly;epithelial to mesenchymal transition;Epithelium;female reproductive tract;Fetus;Gastrointestinal tract structure;Group B Streptococcus colonization;HIV;Host Defense;host microbiota;IL17 gene;Immune;immune activation;Immune response;Immunity;immunodeficiency;In Vitro;in vivo Model;Infant;Infection;Inflammation;Integration Host Factors;Intermediate Filaments;intrauterine infection;Invaded;Keratin-19;Malignant Neoplasms;Mediating;Meningitis;Microbe;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Neonatal;neonatal infection;neonate;normal microbiota;Osteomyelitis;pathobiont;Pathogenesis;placental infection;placental membrane;Play;Pneumonia;Population;Pregnancy;Pregnancy Outcome;Pregnant Women;Premature Birth;Process;Production;Reporter;reproductive tract;Research;response;Risk Factors;Role;Sepsis;Signal Transduction;stillbirth;Streptococcal Infections;Streptococcus;Streptococcus Group B;Surface;System;T-Lymphocyte;Tertiary Protein Structure;Tissues;Toxin;Uterus;Vagina;vaginal fluid;vaginal microbiota;Vimentin;Woman

PROJECT_TITLE: Host and bacterial mechanisms governing Group B streptococcal persistence in the female genital tract

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Narrative  Hundreds of drugs have failed in clinical trials to treat acute ischemic stroke (disease that affects 600,000 Americans annually) due to the inability of concentrating the drug in the brain tissue without causing non-tolerable side effects. To overcome these failures, we will develop a new nanotechnology, in which we package drugs into 100-nanometer drug carriers that are targeted to the key cells in the injured area of the brain (endothelial cells). Using these targeted nanocarriers (that concentrates the drug 200 times in the injured site), we will answer fundamental questions in pharmacology and biology of acute ischemic stroke, while at the same time finding a new treatment approach.

PI_NAMEs: MARCOS-CONTRERAS, OSCAR A. (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acute;Affect;Affinity;Aftercare;Albumins;American;Anatomy;Animal Model;Animals;Anti-Inflammatory Agents;Antibodies;Area;Autoradiography;Behavioral;Binding;Biodistribution;Biology;Blood;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier function;blood-brain barrier permeabilization;Brain;brain cell;Brain Edema;Brain imaging;Brain Injuries;brain parenchyma;Brain region;brain tissue;Cell Adhesion;Cell Adhesion Molecules;cell type;Cells;Cellular Infiltration;cellular targeting;Chemistry;Clinical Trials;Coagulation Process;Complement Activation;Complete Blood Count;cytokine;Data;Disease;Drug Carriers;Drug Delivery Systems;drug development;Drug Kinetics;Drug Packaging;Drug Targeting;Encapsulated;Encephalitis;Endothelial Cells;Endothelium;Enzyme-Linked Immunosorbent Assay;Epitopes;experience;Failure;Flow Cytometry;Functional disorder;Gatekeeping;Goals;Hepatotoxicity;Histology;Home;Homeostasis;Hour;Immunophenotyping;Immunosuppression;improved;Inflammation;Inflammatory;inflammatory milieu;Infrastructure;Injections;injured;Injury;Insulin Receptor;intercellular cell adhesion molecule;Interleukin-10;Intravenous;intravenous administration;Investigation;Ischemia;Ischemic Penumbra;Ischemic Stroke;Leucocytic infiltrate;Leukocytes;Magnetic Resonance Imaging;Maps;Mass Spectrum Analysis;Membrane Proteins;Messenger RNA;Middle Cerebral Artery Occlusion;Molecular Profiling;Monoclonal Antibodies;mortality risk;Mus;nanocarrier;nanomedicine;nanometer;Nanotechnology;Neurons;new technology;novel strategies;novel therapeutic intervention;Organ;overexpression;Pathway interactions;Pharmaceutical Preparations;Pharmacological Treatment;Pharmacology;Phase;Pilot Projects;Plasma Proteins;Pneumonia;Proteins;Publications;Radioisotopes;Radiolabeled;Research Personnel;RNA;Running;seal;Serum;Severities;side effect;Site;Small Interfering RNA;spatiotemporal;Stroke;stroke therapy;Stroke Volume;success;Surface;targeted treatment;Techniques;technology platform;TFRC gene;Therapeutic;Therapeutic Index;therapeutic RNA;Thrombomodulin;Thrombosis;Time;TNF gene;Toxic effect;Transferrin;Treatment Efficacy;uptake;Variant;Vascular Endothelium;Weight;Work

PROJECT_TITLE: Targeting the gatekeepers: Bolstering blood-brain barrier function using targeted nanomedicine in acute ischemic stroke

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-V (91)]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Dietary Supplements;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE The 2020 Dietary Guidelines have highlighted vitamin D as a nutrient of concern; increased risk of vitamin D3 deficiency is observed in Black individuals, individuals with obesity and in pregnant women. The proposed project will use an innovative, trideuterated vitamin D3 approach to obtain the first kinetic data on D3 and 25(OH)D3 dynamics in non-pregnant and pregnant White women and Black women with and without obesity. Findings obtained will identify non-modifiable (genetic ancestry and functional consequences of vitamin D metabolism genes) and modifiable factors (maternal vitamin D status and BMI) that influence vitamin D utilization across gestation.

PI_NAMEs: O'BRIEN, KIMBERLY O (contact);PRESSMAN, EVA KAREN

PROGRAM_OFFICER_NAME: CLARK, DAVID

PROJECT_TERMS: abdominal fat;absorption;Address;Adipose tissue;Adult;adverse birth outcomes;Affect;African ancestry;Age;aged;Appearance;Awareness;Binding;Binding Proteins;Black Populations;Black race;black women;Body Composition;Body fat;Body mass index;Calcitriol;Categories;Cholecalciferol;Data;dietary guidelines;early pregnancy;Educational workshop;Environment;European ancestry;Exhibits;fetal;Gene Proteins;Genes;Genetic;Genetic Markers;genetic variant;Genotype;Gestational Diabetes;Half-Life;Health;healthy pregnancy;High Pressure Liquid Chromatography;High Prevalence;Homeostasis;Hormones;Human;improved;Individual;innovation;insight;Institute of Medicine (U.S.);Kinetics;Knowledge;Life;Low Birth Weight Infant;Low Prevalence;maternal risk;mathematical model;Measures;Metabolic;Metabolic Pathway;Metabolism;Methodology;Methods;Morbid Obesity;National Institute of Child Health and Human Development;Neonatal;Not Hispanic or Latino;novel;Nutrient;Obesity;obesity risk;Oral Ingestion;Outcome;Pathway interactions;personalized strategies;Physiological;Postpartum Hemorrhage;Pre-Eclampsia;Pregnancy;pregnant;Pregnant Women;prenatal;Production;prohormone;Proteins;Recommendation;recruit;Regulation;Reporting;reproductive;Research;Research Support;Risk;Risk Factors;Risk Reduction;Role;Serum;Shapes;Skin Pigmentation;stable isotope;Strategic Planning;subcutaneous;Supplementation;tandem mass spectrometry;Time;United States National Academy of Sciences;Vitamin D;Vitamin D Deficiency;Vitamin D-Binding Protein;Weight;White Women;Woman

PROJECT_TITLE: Impact of Pregnancy, Obesity, and Vitamin D Binding Protein on Vitamin D Kinetics

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Alcohol use disorder (AUD) affects approximately 14.1 million people in the United States. Despite the prevalence of this disorder, we lack a thorough understanding of its underlying neurobiological mechanisms. Here, we propose to use a multi-faceted approach to explore how serotonin signaling can modulate motivation to consume alcohol.

PI_NAMEs: KASH, THOMAS L. (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Affect;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Amygdaloid structure;Anatomy;antagonist;Arousal;Automobile Driving;Behavior;Biological;Brain region;Cell Nucleus;Corticotropin-Releasing Hormone;Corticotropin-Releasing Hormone Receptors;Coupled;Data;Disease;Dorsal;Ethanol;Exhibits;Fiber;Functional disorder;Funding;gamma-Aminobutyric Acid;Genetic;genetic approach;Glutamates;Habenula;Home;Hyperactivity;In Situ;in vivo;Infusion procedures;insight;Intervention;Knowledge;Lateral;Midbrain structure;Modeling;Motivation;Mus;neurobiological mechanism;Neurons;neuroregulation;optogenetics;Output;Pathway interactions;Persons;pharmacologic;Photometry;Physiological Adaptation;Physiology;Prevalence;Public Health;receptor;Receptor Activation;Receptor Signaling;Recording of previous events;Regulation;Resistance;response;Role;Self Administration;Serotonin;Signal Transduction;Slice;Social Behavior;Structure of terminal stria nuclei of preoptic region;System;Testing;Therapeutic Intervention;Transcript;United States;Up-Regulation;Viral;Work

PROJECT_TITLE: Extended Amygdala Regulation of Dorsal Raphe Function in Ethanol Self-Administration

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]