FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: COLUMBIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Children’s mental, emotional, and behavioral disorders, as well as childhood obesity, occur at alarmingly high levels and constitute major public health concerns. The Research Center for Child Well-Being focuses on prevention of both mental health and obesity-related problems in children ages 2-10, emphasizing the promotion of self-regulation and the fostering of nurturing environments for healthy child development. The Center seeks to add to the nation’s scientific workforce for the next generation of prevention research towards greater child well-being.

PI_NAMEs: PRINZ, RONALD J (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Acceleration;Address;Adolescence;Adolescent obesity;Adult;adult obesity;adverse outcome;Affect;Age;Aggressive behavior;Area;Behavior;Behavior Disorders;Behavioral;Cardiovascular Diseases;Centers of Research Excellence;Child;Child Behavior;Child Development;Child Mental Disorders;Child Welfare;Childhood;Clinical Trials;Communities;community advisory board;community engagement;Core Facility;data management;Dedications;Devices;Diabetes Mellitus;dietary;Discipline;Dropout;emotion dysregulation;Emotional;Emotional disorder;Ensure;Environment;evidence base;Faculty;Family;Fostering;Goals;Habits;Health;Health Promotion;High Prevalence;Impairment;implementation intervention;improved;Informal Social Control;Infrastructure;infrastructure development;innovation;Institution;Intervention;Intervention Studies;Joints;Life Style;Link;Logistics;Low income;low socioeconomic status;Mental Depression;mental development;Mental disorders;Mental Health;Mentors;middle childhood;Mission;next generation;Obesity;obesity in children;obesogenic;Outcome;Phase;Physical activity;physical inactivity;poor sleep;Population;Prevalence;prevent;Prevention;Prevention Research;preventive intervention;Problem behavior;programs;Psyche structure;Public Health;recruit;Research;Research Personnel;Research Project Grants;Research Support;Risk;Risk Factors;Risk Reduction;School Drop-Outs;Schools;Scientist;Sleep;social;South Carolina;Stigmatization;Student Dropouts;substance use;success;suicidal;Teenagers;unhealthy lifestyle;Universities;Work

PROJECT_TITLE: Research Center for Child Well-Being


ADMINISTERING_IC: GM

ARRA_FUNDED: N

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Childhood Obesity;Mental Health;Obesity;Pediatric;Prevention

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PROJECT_TERMS: Acceleration;Address;adult obesity;adverse outcome;Age;Area;Behavior;Behavior Disorders;Behavioral;behavioral health;Cardiovascular system;career;Centers of Research Excellence;Child;Child Care;Child Mental Health;Child Welfare;Childhood;clinical center;Clinical Trials;Communities;community advisory board;Complex;Consumption;Core Facility;Data Collection;data management;design;Development;Development Plans;Diabetes Mellitus;elementary school;Emotional;Emotional disorder;Ensure;Environment;experience;Faculty;Family;Fostering;Funding;Goals;Health;High Prevalence;improved;Infrastructure;innovation;Institution;Intervention;Intervention Studies;Intervention Trial;Lead;Leadership;Life Style;Logistics;member;Mental disorders;Mentors;Mission;Nursery Schools;Obesity;obesity in children;obesity treatment;obesogenic;operation;Outcome;Personal Satisfaction;Phase;Postdoctoral Fellow;Prevention;Prevention Research;Prevention trial;preventive intervention;Problem behavior;Procedures;programs;Psyche structure;Public Health;Records;recruit;Reporting;Research;research facility;Research Personnel;Research Project Grants;Resources;Risk Factors;Risk Reduction;Schools;Science;Scientist;Seasons;skills;South Carolina;Statistical Data Interpretation;Substance abuse problem;success;synergism;Teacher Professional Development;Testing;Time;unhealthy lifestyle;Universities

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Immunotherapy;Nanotechnology;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Biomarkers that reliably inform the selection of therapy or prognosis for patients with head and neck squamous cell carcinoma (HNSCC) are lacking. Emerging data suggest that analysis of the profiles of small (30-150 nm) extracellular vesicles (sEV), also known as exosomes, in body fluids is a promising approach to the detection of non-invasive biomarkers in cancer, including HNSCC. This project will simultaneously assess the utility of sEV produced by tumor cells (TEX) and sEV produced by non-malignant cells (NTEX) in HNSCC patients’ plasma as biomarkers of prognosis and/or response to therapy.

PI_NAMEs: DIERGAARDE, BRENDA B.;WHITESIDE, THERESA L. (contact);ZANDBERG, DAN PAUL

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: advanced disease;Aftercare;aggressive therapy;anti-PD-1;Antibodies;Biogenesis;Biological Assay;Biological Markers;Body Fluids;cancer biomarkers;Cancer Patient;cancer therapy;carcinogenesis;Cell Separation;Cells;Characteristics;Clinical;clinical development;clinically relevant;Combined Modality Therapy;Data;Defect;Development;Diagnosis;Disease;Disease Progression;disorder control;Effector Cell;exosome;extracellular vesicles;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;HPV positive;HPV-negative head and neck cancer;Immune;Immune checkpoint inhibitor;Immune System Diseases;Immunocompetence;Immunologics;Immunosuppression;Immunotherapy;improved;improved outcome;Individual;ineffective therapies;Leukocytes;Ligands;Link;Malignant Neoplasms;Mediating;Metastatic/Recurrent;Minority;Molecular;Monoclonal Antibodies;Monoclonal Antibody Therapy;Morbidity - disease rate;mortality;nanoflow cytometry;neoplastic cell;Non-Invasive Detection;Non-Malignant;novel;Outcome;Parents;patient prognosis;Patient Selection;patient subsets;Patients;pembrolizumab;Performance;Phenotype;Plasma;Plasma Cells;potential biomarker;Prediction of Response to Therapy;predictive marker;Prognosis;prognosis biomarker;Prognostic Marker;programs;Proteins;Quality of life;Regulatory T-Lymphocyte;Reporting;Resistance;Resolution;response biomarker;Role;Sampling;Selection for Treatments;standard care;standard of care;T-Lymphocyte;Technology;Testing;therapy resistant;Toxic effect;treatment response;Tumor-Derived;Vesicle;Western Blotting

PROJECT_TITLE: Small extracellular vesicles as biomarkers of prognosis and response to therapy in head and neck cancer

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Mental Health;Pediatric;Prevention

PI_NAMEs: BEETS, MICHAEL W (contact)

PROJECT_TERMS: Address;Adult;Applications Grants;Attention;Behavior Disorders;Behavior Therapy;Behavioral;career;Child;Child Mental Disorders;Child Welfare;Childhood;clinical center;clinical practice;clinical trial protocol;Clinical Trials;Communities;community advisory board;community engagement;Community Participation;Data;Data Collection;data management;design;Educational workshop;Emotional;Emotional disorder;Enrollment;Ensure;Equipment;Evaluation;experience;Faculty;Funding;Goals;Health;high standard;Human;human subject;implementation intervention;implementation process;improved;Informed Consent;Infrastructure;innovation;Institutional Review Boards;instrumentation;Intervention;Intervention Studies;Intervention Trial;Life Style;Logistics;Measurement;Measures;meetings;Mission;Monitor;obesity in children;Outcome;Outcome Study;Participant;Policies;Preparation;Prevalence;Prevention;Prevention strategy;Prevention trial;preventive intervention;primary outcome;Process;prospective;protocol development;Protocols documentation;Psyche structure;recruit;Reporting;Reproducibility;Research;research clinical testing;research facility;Research Personnel;Research Project Grants;Risk Factors;Schools;Scientist;secondary endpoint;secondary outcome;Secure;Services;Specific qualifier value;Statistical Data Interpretation;statistics;success;Technical Expertise;tool;Training;unhealthy lifestyle;United States National Institutes of Health;Universities;Work;Youth

PROJECT_TITLE: Clinical Trials Logistics Core


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE  Wnt/beta-catenin pathway and adenosine monophosphate-activated kinase (AMPK) pathway play crucial roles in regulation of hepatic metabolism. The proposed studies will develop novel small molecules that possess dual activities of Wnt/beta-catenin inhibition and AMPK activation, delineate their molecular mechanism of action, and assess their efficacy and safety for treatment of non-alcoholic steatohepatitis (NASH) which afflicts 12% of US population. The findings are expected to be of great impact as they lead to pharmacological agents for a highly unmet medical need with no approved drugs.

PI_NAMEs: SHU, YAN  (contact);XUE, FENGTIAN

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Address;Adenosine Monophosphate;Adherence;Affect;American;analog;Animal Model;Attention;Azoles;Benign;beta catenin;Biguanides;Binding;Binding Proteins;Biological Assay;Biotinylation;Cells;Chemical Structure;Chemicals;Cicatrix;Clinical;design;Diabetes Mellitus;diet and exercise;dietary control;DNA Sequence Alteration;Down-Regulation;drinking water;drug candidate;drug development;drug discovery;Drug Kinetics;Drug or chemical Tissue Distribution;efficacy evaluation;Evaluation;Exhibits;experimental study;Fatty Liver;Fibrosis;functional decline;Generations;Genetic;genetic manipulation;Goals;Hepatic;Hepatocyte;Hybrids;In Vitro;in vivo;Incidence;Individual;innovation;knock-down;Knowledge;Lead;lead optimization;Life Style;Ligand Binding;Liver;Liver Fibrosis;liver metabolism;liver transplantation;Medical;Metabolic;Metabolic Diseases;Metabolic syndrome;Molecular Mechanisms of Action;mouse model;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutic intervention;novel therapeutics;Obesity;Organic Cation Transporter 1;Outcomes Research;Overnutrition;Pathogenesis;Pathway interactions;Patient Care;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phosphotransferases;Play;Population;Process;Property;Proteomics;Regulation;Research;Resource Development;Role;Safety;sensor;Signal Transduction;small molecule;success;sugar;Swelling;Synthesis Chemistry;Tankyrase;Testing;Therapeutic;therapeutically effective;Toxic effect;transgene expression;western diet;Wettability

PROJECT_TITLE: Axin Stabilization by Novel Small Molecules to Treat Non-alcoholic Steatohepatitis

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Pediatric;Prevention

PI_NAMEs: GERACI, MARCO  (contact)

PROJECT_TERMS: Address;Adherence;Adolescence;Adult;Age;Behavior;Behavioral;Cardiovascular Diseases;career;Child;Child Welfare;Childhood;Clinical Trials;cohort;Complex;Consultations;Core Facility;Data;Data Collection;data management;design;Development;Disease;Educational workshop;Emotional;Environment;experience;Faculty;Feasibility Studies;Foundations;Health;Hospitals;Human Resources;implementation intervention;Individual;Institution;institutional capacity;Intervention;Intervention Studies;Intervention Trial;Laboratories;Leadership;Mediation;member;Mental disorders;Mentors;Methodology;Methods;Mission;Obesity;Outcome;Outcome Study;Personnel Staffing;Phase;Pilot Projects;Prevention;Prevention Research;Prevention trial;preventive intervention;Problem behavior;Procedures;Psyche structure;Public Health;Randomized;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Resources;response;Risk;Risk Reduction;Scientist;Senior Scientist;Services;Statistical Data Interpretation;statistical service;statistics;Structure;Substance abuse problem;Time;Training;unhealthy lifestyle;Universities;Update;Vision

PROJECT_TITLE: Statistical and Data Management Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Infection with bacteria triggers specific responses from the human immune system that help clear the infection. We discovered a protein (NLRP11) that is key to this response in human macrophages. Our goals are to generate insights into how NLRP11 contributes to macrophage responses that facilitate control of infection with certain human bacterial pathogens.

PI_NAMEs: GOLDBERG, MARCIA B (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Adaptor Signaling Protein;Bacteria;Binding;CASP1 gene;CASP4 gene;CASP5 gene;Caspase;Cell Death;Cell Death Induction;Cell surface;Cells;Communities;Complex;Cytosol;cytosolic receptor;Data;Dependence;Dimerization;Family;genome wide screen;Glycolipids;Goals;Human;Immune system;In Vitro;Infection;Infection Control;Inflammasome;Innate Immune System;insight;interest;Ligands;Lipopolysaccharides;Listeria monocytogenes;Macrophage;Mediating;member;Membrane;Micelles;microbial;Modification;Molecular;molecular domain;Mus;mutant;Mutation;Myelogenous;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Pattern recognition receptor;Physiological;Positioning Attribute;Primates;Process;Proteins;response;Rest;Role;sensor;Shigella flexneri;Signal Transduction;Specificity;Testing;TLR4 gene;Transfection;Variant

PROJECT_TITLE: Human NLRP11 function in non-canonical inflammasome activation by bacterial pathogen LPS

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Precision Medicine;Prevention;Stroke

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: NARRATIVE This study will discover plasma protein biomarkers associated with delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH). The aims of this study are consistent with the goals of the NIH and NIND’s R61/R3 PAR-19-315 and it will have a significant impact on public health and will improve SAH care.

PI_NAMEs: CHOI, HUIMAHN ALEX (contact);SAVARRAJ, JUDE PJ

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: Address;Affect;Area;Binding Proteins;Biological Assay;Biological Markers;Biological Process;biomarker identification;biomarker signature;biomarker validation;Blinded;Blood;Blood Tests;Brain;Brain Aneurysms;Brain hemorrhage;candidate identification;candidate marker;candidate validation;Caring;Cerebral Aneurysm;Cerebral hemisphere hemorrhage;Cerebral Ischemia;Characteristics;Clinical;Clinical Research;Clinical stratification;Clinical Trials Design;cohort;Complex;Complication;Data;Detection;detection assay;detection method;Development;effective therapy;Exposure to;Focal Neurologic Deficits;Functional disorder;GDF8 gene;Glycoproteins;Goals;growth differentiation factor 5;guanylate;Health;Hemorrhage;high risk;Hospital complications;Hospitals;Hour;improved;Individual;individualized medicine;innovation;Intensive Care Units;Interferon Type II;Intervention;Intervention Studies;Investigation;Lead;Leucine;Logistic Regressions;machine learning model;Measures;member;minimally invasive;Morbidity - disease rate;neurexophilin;Neurologic Deficit;novel;patient stratification;Patients;Pattern;Performance;Phase;Plasma;Plasma Proteins;Population;Preparation;prevent;Process;prognostic;prognostic assays;prognostic performance;prognostic value;prognostication;prospective;Prospective cohort;protein biomarkers;Proteins;Proteomics;Public Health;randomized, clinical trials;Reproducibility;Research;Resource Allocation;Resources;response;Risk;risk stratification;Rupture;Sampling;scavenger receptor;screening;Sensitivity and Specificity;Series;Specificity;statistical and machine learning;Subarachnoid Hemorrhage;Subarachnoid Space;Technology;Testing;Treatment Side Effects;United States National Institutes of Health;validation studies

PROJECT_TITLE: Discovery of Plasma Biomarkers of Delayed Cerebral Ischemia after Subarachnoid Hemorrhage

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

PHR: PROJECT NARRATIVE Extending heart preservation will overcome critical bottlenecks in transplantation by increasing the availability of hearts, improving long-term patient outcomes, reducing the cost of transplantation, and provide an untapped resource of hearts for research. This project aims to systematically address cell-specific responses and functional consequences of extended preservation and develop targeted strategies to deal with multiple modes of injury, including ischemia and temperature-related stressors.

PI_NAMEs: TESSIER, SHANNON NOELLA (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: 3-Dimensional;Address;Adult;Animal Experimentation;Animal Model;Animals;ANXA5 gene;Apoptosis;Architecture;Biological Assay;Calcium;Cardiac;Cardiac Myocytes;Cell model;Cell Survival;cell type;Cells;Cessation of life;Chemicals;Clinical;clinically relevant;Complex;cost;cryogenics;Dependence;design;Development;Emergency Situation;Endothelial Cells;experimental study;Exposure to;Freezing;functional outcomes;Generations;Heart;Heart Diseases;heart function;heart preservation;Heart Research;Heart Transplantation;Heat-Shock Proteins 70;Homeostasis;Hour;Hypoxia;Hypoxia Inducible Factor;Ice;improved;In Vitro;Injury;Ischemia;ischemic injury;Larva;Length;Libraries;Life;Life Expectancy;Literature;Location;Mammals;Metabolic;Methods;model organism;Modeling;Molecular;mutant;Myocardial Ischemia;Myofibrils;natural hypothermia;Nature;novel;Operative Surgical Procedures;Organ;Organ Donor;Outcome;Outcome Assessment;Patient-Focused Outcomes;Patients;Perfusion;preconditioning;preservation;Procedures;Protective Agents;Proteins;Protocols documentation;Rana;Rattus;Reporter;Research;Resources;response;Risk;scale up;Signal Transduction;Solid;stressor;Structure;success;surgery outcome;Suspensions;System;Technology;Temperature;Time;Tissues;tool;transcription factor;Transgenic Organisms;Translations;Transplantation;United States;usability;Waiting Lists;Wood material;Work;Zebrafish

PROJECT_TITLE: High subzero heart preservation: from zebrafish to mammals

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Research narrative The goal of the proposed research is an understanding of how action selection for goal-directed behavior is implemented in the frontal cortex, basal ganglia, and superior colliculus network. Malfunctions of this multi- regional network lead to repetitive and maladaptive behavior that affect a wide range of normal functions such as learning, motor skills, as well as social psychological well-beings. An understanding of the neural circuits that implement action selection could begin to outline a roadmap that informs treatments of these disease states.

PI_NAMEs: LI, NUO  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Affect;Anterior;Attention deficit hyperactivity disorder;Basal Ganglia;Behavior;Brain;Brain region;central pattern generator;Choices and Control;Complex;Corpus striatum structure;Data;Decision Making;Disease;Drug Addiction;Exhibits;frontal lobe;Ganglia;Goals;Home;insight;Knowledge;Lateral;Lead;Learning;Literature;maladaptive behavior;Maps;Mediating;Modeling;Motor;motor control;Motor Cortex;Motor Pathways;Motor Skills;Movement;Mus;neural circuit;neural network;neuronal circuitry;Neurons;neuropsychiatric disorder;Normal Range;novel;Obsessive-Compulsive Disorder;optogenetics;Outcome;Output;Pathway Analysis;Pathway interactions;Population;Process;Recovery;repetitive behavior;Research;response;social;Source;Standardization;superior colliculus Corpora quadrigemina;Surveys;Synapses;Technology;Testing;Thalamic structure;theories;Time;Well in self;Work

PROJECT_TITLE: Opponent control of action selection in the cortico-basal-ganglia-colliculus loop

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: ATLANTA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Viral evolution presents a major challenge to public health efforts designed to limit the health and economic impacts of seasonal influenza epidemics and pandemics. Our research seeks to address this challenge by elucidating the mechanisms that shape influenza A virus evolution.

PI_NAMEs: LOWEN, ANICE C (contact);WANG, ZHONGDE

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Ablation;Address;Aerosols;Affect;airway epithelium;Anti-viral Response;Bar Codes;Biological;Cavia;Cells;CRISPR/Cas technology;cytokine;deep sequencing;design;economic impact;Environmental Risk Factor;Epithelium;Evolution;fitness;flu transmission;Genetic;Genetic Drift;Genetic Structures;Genetic Variation;Genome;Health;IFNAR1 gene;Individual;Infection;Influenza A virus;Influenza A Virus, H3N2 Subtype;influenza epidemic;influenza virus strain;influenzavirus;Integration Host Factors;Interferon alpha;Interferon Type I;Interferon-beta;Interferons;Kinetics;Knock-out;Lead;Modeling;Molecular;Monitor;Mus;Natural Selections;Panama;pandemic disease;particle;Population;Population Dynamics;Population Genetics;Population Sizes;Positioning Attribute;Predisposition;Process;Property;Proteins;Public Health;receptor;Research;response;reverse genetics;RNA Viruses;Role;Route;seasonal influenza;Seasons;Shapes;Signal Transduction;Site;Spatial Distribution;Testing;tool;transmission process;type I interferon receptor;Variant;Viral;Viral Load result;viral transmission;Virus;virus genetics;Work

PROJECT_TITLE: Role of Type I and III Interferons in Shaping Influenza A Virus Dynamics Within and Between Hosts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-S(90)]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Pediatric;Prevention;Sleep Research;Social Determinants of Health

PI_NAMEs: ADAMS, ELIZABETH  (contact)

PROJECT_TERMS: actigraphy;Address;adequate sleep;Age;Attention;Behavior;behavioral sleep intervention;Child;Child Welfare;Chronic Disease;Communities;community engaged approach;Control Groups;design;Development;Diagnosis;Diet;Disparity;economic disparity;Emotional;emotional functioning;Ensure;experience;Family;follow-up;Future;Goals;group intervention;improved;Intervention;Link;Low income;Low Income Population;meetings;Obesity;obesogenic;parenting intervention;Parents;Personal Satisfaction;Physical activity;physical conditioning;pilot test;Population;Poverty;Prevention;primary caregiver;Problem behavior;Randomized;Randomized, Controlled Trials;recruit;Research;Resources;Risk;Sleep;sleep behavior;social;trial design;tv watching;virtual;Waiting Lists;Well in self;Work

PROJECT_TITLE: Parenting Intervention to Improve Young Children's Sleep in Families with Low Income


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Biotechnology;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Prevention;Rare Diseases;Social Determinants of Health;Tuberculosis

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Individuals residing in prisons have among the highest rates of tuberculosis worldwide, and this risk remains elevated for years following release from prison. How to effectively and screen for and diagnose tuberculosis in resource-constrained settings remains unclear. This project aims to investigate novel strategies for tuberculosis case finding and monitoring of transmission in high tuberculosis-burden prisons in Brazil, with a goal of identifying scalable strategies to protect the health of incarcerated people and their communities.

PI_NAMEs: ANDREWS, JASON RANDOLPH (contact);CRODA, JULIO

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Acceleration;Address;Algorithms;Americas;Benchmarking;Biological Markers;Blood;Brazil;case finding;Cause of Death;Cessation of life;cohort;Cohort Studies;Communicable Diseases;Communities;Conscious;cost;cost effective;cost effectiveness;Country;COVID-19;COVID-19 pandemic;Data;deep learning;deep learning algorithm;density;Detection;diagnostic accuracy;Digital Radiography;Digital X-Ray;Disease;effective therapy;Electricity;Enrollment;Epidemic;Future;Gene Expression Profiling;genome sequencing;genomic data;Genomics;Goals;Haplotypes;Health;Health protection;high risk;high risk population;Image;Immune response;Imprisonment;improved;Incidence;Individual;Infection;Longitudinal cohort;Longitudinal trends;low and middle-income countries;Low Dose Radiation;Mass Screening;mathematical model;Measures;Methods;Molecular;Monitor;mortality;Mycobacterium tuberculosis;new technology;Notification;novel;novel strategies;Participant;Persons;Population;Population Sizes;portability;Prevalence;prevent;Prevention;Prevention Measures;Preventive therapy;Prisons;progression risk;Recommendation;Resource-limited setting;Risk;Roentgen Rays;Sampling;screening;sobriety;Specificity;Sputum;success;System;Testing;Thoracic Radiography;Time;tool;transmission process;trend;Tuberculosis;Tuberculosis diagnosis;Validation;virtual;whole genome;Work

PROJECT_TITLE: Strategies for tuberculosis control in prisons

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Physical Activity;Prevention;Social Determinants of Health;Substance Misuse

PI_NAMEs: GOODRUM, NADA MUSSAD (contact)

PROJECT_TERMS: Address;aged;Behavior;Child;Child Rearing;Child Welfare;Chronic;Coping Skills;Economics;effective intervention;Emotional;emotional behavior;emotional functioning;experience;Face;Family;Feasibility Studies;Financial Hardship;Health;Health behavior;healthy lifestyle;HIV;implementation process;improved;Informal Social Control;innovation;Intervention;Life Style;Mental disorders;Mental Health;Methods;Moods;Outcome;Parents;Physical activity;Prevalence;Prevention;preventive intervention;programs;protective factors;racial discrimination;Randomized;Recording of previous events;Research;Risk Factors;Sampling;skills;Sleep;social;social skills;Stress;Stress and Coping;stress reduction;stressor;substance misuse;Substance Use Disorder;Trauma;tv watching;unhealthy lifestyle;Waiting Lists

PROJECT_TITLE: Strengthening Child Social-Emotional Functioning and Healthy Lifestyle Behaviors Through Parent-Based Prevention in Families Experiencing Major Stressors


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: ANN ARBOR

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The proposed research is highly relevant to public health because of the need for modeling tools to guide more effective, rapid responses to emerging outbreaks and future pandemics. We propose to develop models that place social and epidemiological determinants of infection on equal footing and that integrate data and models from the individual to the population level using highly-detailed information from longitudinal cohort and clinical data. These models will evaluate disparities in incidence and burden of emerging pathogens as well as vaccination coverage and effectiveness to promote equitable mitigation of future outbreaks at the population level. This research is relevant to the mission of the NIMHD in that it will inform future modeling efforts to guide vaccination and other public health approaches that will reduce disparities in outbreaks of emerging infections.

PI_NAMEs: ZELNER, JONATHAN L (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: 2019-nCoV;Address;Attitude;Automobile Driving;Base Ratios;Behavior;Behavioral;Biological;Biological Models;Childhood;Clinical Data;Clinical effectiveness;Communicable Diseases;COVID-19;COVID-19 incidence;COVID-19 mortality;COVID-19 pandemic;COVID-19 vaccination;Data;Data Analyses;Data Collection;data integration;design;Dimensions;Disease;Disease Outbreaks;Disease Progression;disease transmission;Disparity;disparity reduction;Dose;dynamic system;Effectiveness;effectiveness evaluation;Emerging Communicable Diseases;Emerging infection;emerging pathogen;Ensure;Epidemic;epidemic response;Epidemiologic Factors;Epidemiology;Equity;Ethnic Origin;Etiology;Evaluation;foot;Foundations;Frequencies;Future;future epidemic;future outbreak;future pandemic;geographic disparity;Geography;Goals;health care availability;Herd Immunity;Immunity;Incidence;Individual;Inequality;Inequity;Infection;infection risk;infectious disease model;Intervention;intervention effect;Intervention Studies;Joints;lens;Limb structure;Long-Term Effects;Longitudinal cohort;low socioeconomic status;Masks;Measles;Measures;Medical Sociology;Methods;Mission;Modeling;models and simulation;Morbidity - disease rate;mortality;mortality risk;National Institute on Minority Health and Health Disparities;Nature;Neighborhoods;new outbreak;Observational Study;Outcome;outcome disparities;pandemic disease;pandemic potential;pandemic response;pathogen;Phase;Policies;Population;population based;Population Surveillance;Predisposition;prevent;prospective;Prospective Studies;protective effect;Public Health;Race;racial disparity;racial minority;Readiness;Research;Research Design;residential segregation;response;Risk;Series;simulation;social;social contact;social determinants;social disparities;social epidemiology;social factors;Social Interaction;socioeconomic disparity;Socioeconomic Status;socioeconomics;Sociology;Statistical Models;surveillance data;surveillance study;Surveys;therapy design;Thinking;Time;tool;transmission process;Vaccination;vaccine access;vaccine hesitancy;Vaccines;Work;Yawning

PROJECT_TITLE: Systems modeling to address the social and biological drivers of disparities in infection and mortality from emerging infectious diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: COOPER, DANIEL KABAT (contact)

PROJECT_TERMS: Address;Age;Behavior;Black race;Child;Child Health;Child Rearing;Child Welfare;cost effective;Educational process of instructing;Effectiveness of Interventions;effectiveness/implementation design;Emotional;emotional functioning;Ethnic Origin;Family;future implementation;Health;healthy lifestyle;implementation trial;improved;information gathering;Intervention;intervention delivery;intervention effect;Knowledge;Latinx;Minority;minority children;minority health disparity;novel;Nursery Schools;Outcome;parenting intervention;Pilot Projects;Play;Prevention;Prevention approach;Prevention program;preventive intervention;Race;racial population;racism;Reduce health disparities;Research;School-Age Population;social;Socialization;Testing;universal prevention

PROJECT_TITLE: Family-Based Prevention to Promote the Social-Emotional Functioning and Healthy Lifestyle Behaviors of Black & Latinx Children


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Pediatric;Prevention;Sleep Research;Social Determinants of Health

PI_NAMEs: BURKART, SARAH  (contact)

PROJECT_TERMS: 6 year old;Accelerometer;acceptability and feasibility;Attention;Behavior;Behavioral;Child;Child Development;Child Welfare;Data;design;Development;elementary school;feasibility testing;Focus Groups;Home;Impaired cognition;improved;innovation;Intervention;kindergarten;Modeling;Nursery Schools;Obesity;Parents;Patient Self-Report;Performance;pilot test;prevent;Prevention strategy;Randomized, Controlled Trials;Reporting;Research;Risk;school environment;Schools;Signal Transduction;Sleep;sleep behavior;Sleep Deprivation;Sleep Disorders;sleep pattern;social;Structure;teacher;Testing;therapy development;Time;trial design;Well in self;Wrist

PROJECT_TITLE: Prevention Strategies to Enhance Young Children's Sleep Development


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Social Determinants of Health

ORG_CITY: BEIRUT

ORG_COUNTRY: LEBANON

ORG_FIPS: LE

ORG_NAME: AMERICAN UNIVERSITY OF BEIRUT

PHR: Project Narrative (3 sentences) The Middle East and North Africa (MENA) region faces a myriad of environmental and occupational health (EOH) challenges in a context of dynamic political changes and multiple concurrent humanitarian crises. The proposed collaborative U01 (led by the American University of Beirut, Lebanon) and U2R (led by Yale University in collaboration with the University of Iowa in the US) applications aim to establish a Global Environmental and Occupational Health Research and Training Hub for the MENA region (GEOHealth MENA) with the goal to build and strengthen EOH research capacity at academic/research institutions and relevant NGOs in the region. With the purpose of informing policy and practice guidelines, the U01 research project will evaluate pathways of pesticide exposure among Syrian refugee agricultural workers, investigate its association with neurobehavioral performance, and explore the role of social factors in this association, while providing a platform for short-term (workshops, courses) and long-term training (MPH, PhD) to health professionals from the MENA region supported by the U2R.

PI_NAMEs: HABIB, RIMA ;MOWAFI, HANI ;NUWAYHID, IMAN A (contact);REDLICH, CARRIE A

PROGRAM_OFFICER_NAME: JESSUP, CHRISTINE

PROJECT_TERMS: Age;Agricultural Workers;Agriculture;American;Biological;Characteristics;Child;Chlorpyrifos;cohort;Collaborations;Communities;Conflict (Psychology);cost;Country;cypermethrin;decamethrin;Deposition;Diet;Disparity population;displaced person;Doctor of Philosophy;Dose;Economics;Educational workshop;Egypt;Environmental Exposure;Environmental Health;Epidemiology;exposure route;Exposure to;Face;Faculty;Failure;Fellowship;Female;global environment;Goals;Health;Health Professional;Health Sciences;health training;improved;Individual;Ingestion;Institution;Interdisciplinary Study;Investments;Iowa;Lead;Lebanon;low and middle-income countries;male;Measures;Medicine;Methods;Middle East;Migrant;neurobehavioral;Northern Africa;Occupational;Occupational Exposure;Occupational Health;Occupational Medicine;Organophosphates;Outcome;Pathway interactions;Performance;pesticide exposure;Pesticide Residues;Pesticides;Policies;Politics;Population;Populations at Risk;Practice Guidelines;pyrethroid;Qualifying;recruit;Refugees;Regulation;Research;Research Project Grants;Research Training;response;Risk;Role;Route;Safety;Scholarship;Seasons;sex;Sister;social factors;social stressor;socioeconomics;Sudan;Syria;Time;tool;Training;Translating;Universities;urinary;Vulnerable Populations;wearable device;Woman;Work;wristband

PROJECT_TITLE: 1/2 - The Global Environmental and Occupational Health Research and Training Hub for the Middle East and North Africa Region (GEOHealth-MENA) - Lebanon

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Q(70)R]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Substance Misuse

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

ORG_STATE: RI

PHR: 8. PROJECT NARRATIVE  Adolescent cannabis use is a significant public health concern because it predicts poor cognitive, educational, and occupational outcomes. Brain mechanisms of cognitive flexibility and reward motivation, two processes linked to functional impairment and addiction in adult substance use, have been neglected in studies of adolescent cannabis use. The proposed research and career development activities will provide the trainee with critical skills in (a) research assessment of adolescent cannabis use, (b) neuroimaging, and (c) computational modeling, facilitating her transition to an independent scientist whose work uses brain- mechanisms to identify factors explaining the transition from substance use to addiction in order to inform the design of targeted treatments.

PI_NAMEs: THOMAS, SARAH ANN (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: 17 year old;Acceleration;addiction;Address;Adolescence;Adolescent;adolescent brain development;adolescent drug use;Adolescent marijuana use;adolescent substance use;Adult;adverse outcome;Affect;Age;Area;Award;Behavior;Behavioral;Behavioral Mechanisms;Behavioral Model;biobehavior;Biological;Brain;brain based;Brain region;Cannabinoids;Cannabis;career;career development;Chronic;Cognitive;cognitive control;Computer Models;Corpus striatum structure;Data;Data Analyses;Decision Making;design;Development;Diffusion;Drug usage;Education;Educational workshop;Environment;Etiology;Exhibits;Failure;flexibility;Functional impairment;Functional Magnetic Resonance Imaging;Goals;high school;Impaired cognition;Impairment;improved;Individual;innovation;Intervention;Investigation;Knowledge;Learning;Link;longitudinal design;Magnetic Resonance Imaging;maladaptive behavior;marijuana use;marijuana user;Measures;Mediating;Mentors;Mentorship;Methodology;Methods;Modeling;Motivation;National Institute of Drug Abuse;neglect;neural;neural circuit;neural recruitment;Neuroanatomy;neurobehavioral;neuroimaging;Neurosciences;non-drug;novel;Occupational;Outcome;Pathway interactions;patient oriented;Pharmacotherapy;phenomenological models;Prefrontal Cortex;Prevention;Process;Psychiatry;Psychological reinforcement;Public Health;Publications;Punishment;receptor;Research;research and development;Research Personnel;Research Project Grants;Resources;response;Rest;Reversal Learning;Rewards;Risk;Scientist;skills;Statistical Methods;Statistical Models;Stimulus;Strategic Planning;substance use;success;symposium;Symptoms;Testing;Training;treatment response;Universities;Visit;Work

PROJECT_TITLE: Cognitive flexibility and reward motivation in adolescent cannabis use: An investigation of neurobehavioral mechanisms and intrinsic resting state connectivity.

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Prevention;Rare Diseases

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project narrative While most of the tumors in the head and neck region can be cured when discovered early, treatments are often ineffective when these tumors are discovered late. Since most head and neck cancers are found late, only when they become symptomatic, there is a need for non-invasive diagnostic tests to detect them early. We propose to develop a test able to discover the tumor from the oral rinse by checking for the presence of part of cells called myeloid derived suppressor cells that are present only in the tumor and that cancer needs to develop.

PI_NAMEs: FRANZMANN, ELIZABETH J;SERAFINI, PAOLO  (contact);WEED, DONALD TOPPING

PROJECT_TERMS: Age;Antibodies;Antigens;aptamer;Benign;Biological Assay;Biological Markers;Biopsy;Blood;Cancer Patient;Case/Control Studies;CD44 gene;Cells;chemical synthesis;Circulation;Clinic;Clinical;Clinical Research;cohort;combinatorial;Communities;cost;Data;Detection;Development;Diagnosis;diagnostic assay;Diagnostic tests;diagnostic tool;Dimensions;Disease;Early Diagnosis;Enrollment;Epitopes;experimental study;Goals;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Heterogeneity;Histologic;Human;human disease;Human Papillomavirus;hypopharynx;Immunologic Surveillance;Infiltration;Institution;Label;Larynx;Lesion;Ligands;Lipids;Liquid substance;Macrophage;Malignant - descriptor;malignant mouth neoplasm;Malignant Neoplasms;Medical;Monitor;Morbidity - disease rate;Mouth Neoplasms;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasms;neoplastic;neoplastic cell;noninvasive diagnosis;novel strategies;Oligonucleotides;Operative Surgical Procedures;Oral;Oral cavity;Oral Diagnosis;Oropharyngeal;Otolaryngology;pathogen;patient subsets;Patients;Peptides;Phenotype;Population;Prognosis;prospective;Proteins;proteomic signature;Proteomics;Recording of previous events;Recurrence;Resistance;Resolution;Ribonucleases;RNA;Role;Running;Saliva;Sampling;Sensitivity and Specificity;Side;Site;Specificity;Structure;Surface Plasmon Resonance;Survival Rate;synthetic antibodies;Techniques;Testing;Therapeutic;Time;Tissues;Toxin;tumor;Tumor Escape;tumor growth;tumor initiation;Tumor Markers;tumor microenvironment;tumor progression;Tumor Promotion;Tumor stage;tumorigenesis;Vertebral column

PROJECT_TITLE: Aptamer specific for myeloid derived suppressor cells for the diagnosis of head and neck cancer from the oral rinse


ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

PHR: PROJECT NARRATIVE  By using the novel mouse models of human hereditary pancreatitis we recently developed, we will test our novel hypothesis that, in addition to gain-of-function features of PRSS1, the expression levels of trypsinogens and the location of active enzymes determine the spontaneous initiation and severity of hereditary pancreatitis. This study will provide novel insights into the spontaneous initiation of hereditary pancreatitis and the pathogenesis of hemorrhagic pancreatitis and pave the ways for developing novel effective preventive and therapeutic interventions.

PI_NAMEs: JI, BAOAN  (contact);WANG, YING

PROGRAM_OFFICER_NAME: SERRANO, JOSE

PROJECT_TERMS: Acinar Cell;acute pancreatitis;Age;Animal Model;Automobile Driving;autosome;Birth;Blood Vessels;Bombesin;chronic pancreatitis;Development;Diet;Disease;Dose;Duct (organ) structure;Enzymes;Exposure to;extracellular;FDA approved;gain of function;gain of function mutation;Gastroenterology;Gene Expression;genetic approach;Genetic Transcription;Hemorrhage;hereditary pancreatitis;Heterozygote;Hormones;Human;human model;inhibitor;Injury;innovation;insight;interstitial;Intervention;Ischemia;Location;Malignant neoplasm of pancreas;Modeling;Molecular;mouse model;Mus;mutant;Neurotransmitters;neutralizing antibody;novel;Obstruction;Pancreas;Pancreatic duct;Pancreatitis;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;preventive intervention;Recurrence;Regulation;Risk;Role;Severities;Signal Pathway;Stimulus;targeted treatment;Testing;Therapeutic Effect;Therapeutic Intervention;transgene expression;Translating;translational potential;Trypsin;Trypsinogen;Up-Regulation;Wild Type Mouse

PROJECT_TITLE: Mechanisms of Hereditary Pancreatitis

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Prostate cancer (PCa) remains an incurable disease once progression to the metastatic castration-resistant (mCRPC) state occurs; killing >30,000 U.S. men/yr. Herein, we put forward an innovative strategy to selectively exploit selective vulnerabilities in neuroendocrine prostate cancer (NEPC), a highly aggressive variant of mCRPC, using an orally-bioavailable and highly specific LSD1 inhibitor, bomedemstat, in clinical development for unrelated indications. Furthermore, genome-scale analyses integrated with pharmacogenomics pipelines provide a rich mechanistic understanding of the genetic and epigenetic molecular features underlying the mCRPC subtype specificity to LSD1 inhibition, which will guide patient selection in future biomarker-driven clinical trials.

PI_NAMEs: BRENNEN, WILLIAM NATHANIEL (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: abiraterone;androgen independent prostate cancer;Androgen Receptor;ASCL1 gene;Biological Availability;Biological Models;biomarker driven;Cancer Patient;cancer subtypes;Castration;Cells;Clinical;clinical development;Clinical Trials;cohort;combat;Combined Modality Therapy;Data;Development;Discrimination;Disease;Dose;Drug Combinations;Drug Kinetics;Drug resistance;effective therapy;enzalutamide;Epigenetic Process;FDA approved;Frequencies;Future;Genetic;Genetic Transcription;genome-wide;Goals;Heterogeneity;Hormonal;In Vitro;in vivo;inhibitor;innovation;Innovative Therapy;insulinoma associated 1;KDM1A gene;Lesion;Malignant neoplasm of prostate;Mediator;men;Mixed Neoplasm;Modeling;Molecular;Neuroendocrine Prostate Cancer;New Agents;novel;Oral;Organoids;Pathologic;Pathway interactions;patient derived xenograft model;Patient Selection;Patients;Pharmaceutical Preparations;Pharmacogenomics;Phenotype;Pre-Clinical Model;precision medicine;predictive marker;Predisposition;Prevalence;Prognosis;programs;Proliferating;prostate cancer cell;Prostate Cancer therapy;rational design;Resistance;resistance mechanism;response;response biomarker;Safety;screening;Specificity;standard of care;synergism;targeted agent;targeted treatment;Technology;Testing;Therapeutic;therapy resistant;tumor;Variant;Work

PROJECT_TITLE: Molecular features promoting sensitivity to LSD1i in castration-resistant prostate cancer

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sleep Research;Social Determinants of Health;Sudden Infant Death Syndrome

ORG_CITY: WORCESTER

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: SMART Preemie Project Narrative Sudden and Unexpected Infant Death (SUID) occurs 2-3-fold higher among preterm infants, compared to healthy, term infants, despite prolonged hospitalization and multiple touch points with medical providers. Our R01 “Study of Attitudes and Factors Effecting PREterm infant care Practices” (SAFE PREP) found alarming rates of modifiable, unsafe sleep practices, including non-supine sleep among 51% and bedsharing among 24% of US preterm infants recruited from 30 NICUs across the US. In this renewal application, “SMART Preemie,” we proposed a hybrid type 1 implementation effectiveness, cluster randomized trial. We will study the (1) impact of safe sleep education interventions occurring in the a) hospital and b) post-discharge time periods versus an attention-matched control (shared reading) on adherence to safe sleep practices and (2) key implementation outcomes (feasibility, acceptability, fidelity, and sustainability) to inform future scale-up.

PI_NAMEs: HWANG, SUNAH S;PARKER, MARGARET GRAHAM KEMPER (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: 37 weeks gestation;Academy;Address;Adherence;American;Apnea;Attention;Attitude;Back to Sleep;Beds;Behavior;Black race;Cluster randomized trial;compare effectiveness;Data;Death Rate;Decision Making;Devices;Education;Educational Intervention;Effectiveness;effectiveness testing;effectiveness/implementation hybrid;Environment;Epidemiology;ethnic disparity;Ethnic Origin;Ethnic Population;experience;Future;gastrointestinal;General Population;Gestational Age;Health behavior;Health Personnel;high risk population;Hispanic;Hospitalization;Hospitals;Hybrids;implementation framework;implementation outcomes;implementation study;implementation/effectiveness;improved;Individual;Infant;Infant Care;Infant Mortality;Intervention;intervention delivery;intervention effect;Intervention Studies;Location;Maternal Behavior;Mediating;Medical;medical vulnerability;mHealth;mhealth interventions;Modeling;Monitor;mortality risk;Mothers;Neonatal Intensive Care Units;neurodevelopment;Not Hispanic or Latino;Pediatrics;Planning Theory;Population;Population Heterogeneity;Positioning Attribute;post intervention;postneonatal mortality;Premature Birth;Premature Infant;Prevalence;Prevalence Study;Proctor framework;Provider;Public Health;Race;racial disparity;racial population;Randomized;Reading;Recommendation;recruit;Reflux;Reporting;Research Design;Risk Reduction;Safety;scale up;Site;Sleep;sleep behavior;sleep position;social media;social norm;socioeconomics;successful intervention;Sudden infant death syndrome;Supination;Supine Position;supine sleep;Testing;Text Messaging;Time;Training;Translating;Work

PROJECT_TITLE: Social Media and Risk-reduction Training for Preterm Infant Care Practices (SMART Preemie)

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Kidney Disease;Lupus;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative Lupus nephritis is a significant burden to patients with systemic lupus erythematosus, but currently the prognostic utility of the kidney biopsy is lacking. Therefore, novel approaches are required to obtain continuous, quantitative data to improve accuracy, reproducibility, and prognostic utility. In this project we will apply detailed quantitative morphologic scoring, supervised computer-aided deep learning image analysis algorithms with morphometric analysis, and unsupervised machine learning approaches to establish improved methods of kidney biopsy interpretation in lupus nephritis.

PI_NAMEs: BUYON, JILL P;HODGIN, JEFFREY BENTON (contact);MARIANI, LAURA H;SARDER, PINAKI

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Acceleration;Adult;African ancestry;Algorithmic Analysis;Attention;Biopsy;Caring;Categories;Chronic;Classification;Clinical;clinical application;clinical care;Clinical Data;Clinical Research;Clinical Trials;clinically relevant;cohort;Collaborations;Computer Assisted;Data;data integration;data mining;Data Set;deep learning;Descriptor;Diagnosis;Dialysis procedure;Digital biomarker;digital imaging;digital pathology;Disease;disease heterogeneity;Disease Progression;Disease remission;efficacious treatment;End stage renal failure;Environment;Evaluation;Evolution;experience;explainable artificial intelligence;follow-up;General Population;Goals;High Prevalence;Histologic;Human;Image;Image Analysis;image archival system;Imaging technology;improved;improved outcome;indexing;Individual;Injury;International;Kidney;kidney biopsy;Kidney Diseases;Kidney Transplantation;Learning;Life Expectancy;light microscopy;Lupus;Lupus Nephritis;Machine Learning;machine learning algorithm;Measurable;Measures;Medicine;Methods;Michigan;Minority Groups;Morphology;mortality risk;multimodal data;multimodality;Nephrology;Nephrotic Syndrome;novel;novel strategies;Outcome;participant enrollment;Pathologist;Pathology;Patients;Pattern;peer;predict clinical outcome;Prediction of Response to Therapy;Prevention;prognostic;prognostic significance;prognostic value;progression risk;Protocols documentation;Publications;Renal function;Reproducibility;Research;response;Scanning;self-attention;Slide;Societies;System;systematic review;Systemic Lupus Erythematosus;Testing;Treatment Failure;treatment risk;Uncertainty;United States National Institutes of Health;Universities;unsupervised learning;Update;whole slide imaging;Work

PROJECT_TITLE: Digital Pathology and Computational Image Analysis for Lupus Nephritis

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Nutrition

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Insects are vectors for many pathogens that contribute to the deaths of more than a million people each year. Mosquitoes and other biting insects use a variety of gustatory cues to identify their human targets, but the molecular mechanisms underlying insect taste receptors are poorly understood. Here, we propose to elucidate the structure and function of insect taste receptors, thus providing a critical foundation for developing new strategies to limit the human and financial damage caused by insect pests.

PI_NAMEs: BUTTERWICK, JOEL ADAM (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Affect;Afferent Neurons;Amino Acids;analog;Animals;antagonist;base;Binding;Biological Assay;Biophysics;Bombyx mori;Cations;Cells;Cessation of life;chemical group;Chemicals;Chemoreceptors;Collection;Complex;Coupled;Couples;Cues;Culicidae;Data;design;Detection;detection of nutrient;Disaccharides;Discrimination;Docking;Drosophila gustatory receptor;Esthesia;experimental study;Family;Food;Foundations;Fructose;Glucose;Hexoses;Human;human pathogen;In Vitro;Insect Bites;Insect Vectors;Insecta;Ion Channel;Ions;Life;Ligand Binding;Ligands;Link;Metabolic;Methods;Modeling;Molecular;Moths;Mutagenesis;novel;Nutritional;Outcome;pathogen;Pattern;Persons;Poison;Potential Energy;receptor;receptor binding;response;Role;Route;Side;Silk;small molecule;Specificity;structural biology;Structure;Sucrose;sugar;sweet taste perception;Taste Buds;Taste Perception;taste system;tool;Trehalose

PROJECT_TITLE: Molecular Mechanisms of Sugar Sensing by Insect Gustatory Receptors

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Lung;Nutrition;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE Undernutrition is the most common cause of tuberculosis (TB) disease worldwide, but despite curative antibiotics people with undernutrition commonly suffer failure of TB treatment. We found that conventional dosing of anti-TB antibiotics led to suboptimal serum concentrations that contributed to treatment failure. However, we also found that the suboptimal serum concentrations can be approximated by measuring the amount of drug that is excreted in the urine. We propose to study the efficacy and safety of dose personalization of a common anti-TB antibiotic based on urine excretion in adults and children with TB from a region burdened by undernutrition. We will also study the reasons why undernourished people may have suboptimal drug concentrations, including the presence of gut pathogens or gastrointestinal malabsorption.

PI_NAMEs: HEYSELL, SCOTT K (contact);KAGAN, LEONID

PROGRAM_OFFICER_NAME: LAUGHON, BARBARA E

PROJECT_TERMS: Adult;Adverse event;age stratification;Antibiotics;Antitubercular Agents;Antitubercular Antibiotics;Area;Attenuated;Bacterial Drug Resistance;bactericide;Biological Assay;Biological Markers;Bypass;Cessation of life;Characteristics;Child;Clinical;clinical predictors;clinically relevant;clinically significant;cohort;Cold Chains;Collection;Colorimetry;conventional dosing;curative treatments;Diarrhea;Disease;Dose;Drug Kinetics;Drug Targeting;drug-sensitive;efficacy study;efficacy testing;Enteral;enteric pathogen;Evaluation;Excretory function;Exposure to;Failure;Feces;Functional disorder;gastrointestinal;gut inflammation;improved;Individual;Inflammation;Intervention;Intestinal Mass;Intestinal permeability;Kinetics;Knowledge;laboratory equipment;Malabsorption Syndromes;Malnutrition;Mass Spectrum Analysis;Measurement;Measures;Medicine;Morbidity - disease rate;mortality;Outcome;Participant;pathogen;Pathogen detection;Permeability;personalized strategies;Persons;Pharmaceutical Preparations;Phase;point of care;Point-of-Care Systems;Population;Predisposition;preservation;Process;Pulmonary Tuberculosis;Randomized;randomized, controlled study;Regimen;Resistance;response;Rifampin;Rifamycins;Role;Safety;Selection for Treatments;Serum;Spectrophotometry;Stains;System;Tablets;Tanzania;temporal measurement;Testing;Time;Treatment Failure;Treatment outcome;treatment response;trial design;Tuberculosis;tuberculosis drugs;tuberculosis treatment;urinary;Urine;Weight

PROJECT_TITLE: Urine Colorimetry for Tuberculosis Pharmacokinetics Evaluation in Children and Adults

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project narrative Diffuse large B cell lymphoma (DLBCL) is the most common hematologic malignancy in the United States. Approximately 40% of adult DLBCL patients relapse or are refractory to current frontline therapy, thus there is an urgent need for new effective therapies. Using chemical biology combined with a high-throughput 930 cancer cell line screen, we identified 4’-ethynyl-deoxycytidine as a unique pre-clinical therapeutic for DLBCL which we plan to further investigate and develop herein.

PI_NAMEs: EISCHEN, CHRISTINE M.;POMERANTZ, RICHARD T (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: absorption;Acute leukemia;Adult;anticancer activity;Apoptotic;BCL2 gene;Biological Markers;Biology;Body Weight decreased;cancer cell;Cancer cell line;cancer genetics;Cell Line;Cessation of life;Chemicals;Child;Cytarabine;Cytidine;Cytidine Deaminase;Data;Deoxycytidine;Disease Progression;DNA Damage;DNA replication fork;Dose;Doxorubicin;Drug resistance;effective therapy;Effectiveness;Epigenetic Process;Exhibits;experimental study;EZH2 gene;Female;gemcitabine;Genes;genetic analysis;Hematologic Neoplasms;Human;in vivo;inhibitor;large cell Diffuse non-Hodgkin's lymphoma;leukemia/lymphoma;liquid chromatography mass spectrometry;Lymphoma cell;male;Malignant Neoplasms;Metabolism;Mus;nanomolar;next generation;Non-Hodgkin's Lymphoma;novel;novel therapeutics;nucleoside analog;Nucleosides;nucleotide metabolism;overexpression;Pathway interactions;Patients;Pharmaceutical Preparations;Phosphorylation;pre-clinical;predictive marker;Predisposition;Prodrugs;Proliferating;Protein Analysis;Proteins;Refractory;Relapse;relapse patients;replication stress;Resistance;resistance mechanism;response;Sampling;scaffold;standard of care;Stress;System;Testing;Therapeutic;Toxic effect;transcriptome sequencing;tumor;United States;Xenograft procedure

PROJECT_TITLE: A Next-Generation Nucleoside Prodrug for Diffuse Large B-Cell Lymphoma

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Maternal Health;Microbiome;Nutrition;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: WASHINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE The effects of consuming non-nutritive sweeteners (NNS) during pregnancy and lactation on infant obesity and cardiometabolic disease risk are not well understood. In this project, pregnant women who frequently consume NNS will be randomly assigned to an NNS-restriction intervention (NNS restriction during pregnancy and lactation or during lactation only) or a control group (no NNS restriction) to determine whether NNS consumption during pregnancy and/or lactation affects infant body composition, maternal blood sugar during pregnancy, and the infants’ gut microbiome and metabolome. The results of this study have the potential to shape recommendations around NNS consumption during pregnancy and lactation, thereby potentially improving maternal and infant metabolic health and reducing the global burden of obesity and cardiometabolic disease.

PI_NAMEs: SYLVETSKY, ALLISON  (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Adherence;Adult;Affect;Age Months;Air;Automobile Driving;Beverages;Blood Glucose;blood glucose regulation;Body Composition;Body fat;Body mass index;Cardiometabolic Disease;cardiometabolic risk;Childhood;Chronic;Cohort Studies;Consultations;Consumption;Control Groups;Counseling;Data;Development;diabetes risk;dietary;Dietitian;Disease;disorder risk;dosage;early life exposure;Ethics;Exclusive Breastfeeding;Exposure to;Fatty acid glycerol esters;Feces;fetal;Food;Future;Gestational Diabetes;Glucose Intolerance;glucose tolerance;Growth;Guidelines;gut dysbiosis;gut microbiome;gut microbiota;Health;Home;Hour;Human;Human Characteristics;Human Milk;Hypoglycemia;improved;in utero;Infant;infant adiposity;infant gut microbiome;Infant Health;infant outcome;Inflammation;Inflammatory;insulin sensitivity;Intake;intergenerational;Intervention;Lactation;Life;Maternal Health;maternal outcome;Measures;Metabolic;metabolome;metabolomics;Metagenomics;Microbe;mother nutrition;Mothers;Mus;Obesity;Observational Study;offspring;offspring obesity;OGTT;Outcome;Pathway interactions;Physiological;Plethysmography;postnatal;Postpartum Period;Pregnancy;Pregnant Women;prenatal;prenatal exposure;Prospective, cohort study;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Risk Factors;Rodent;Rodent Model;Safety;Shapes;Solid;Sweetening Agents;Thinness;Toxicology;transmission process;United States;Urine;Uterus;Weight;Woman

PROJECT_TITLE: Effects of a non-nutritive sweetener reduction intervention in pregnancy and lactation on maternal and infant outcomes (the SWEETPEA trial)

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: GAINESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE Essential voice tremor (EVT) affects over 40% of individuals with essential tremor (ET), one of the most common movement disorders characterized primarily by upper limb tremor. Although thalamic deep brain stimulation (DBS) has become the go to treatment for severe and drug-refractory ET, we are still at the early stages of understanding its capacity to treat EVT. Here, we propose to identify thalamic targets that optimize EVT suppression in ET patients undergoing DBS treatment for upper limb tremor and determine if EVT suppression is a marker for axial tremor suppression and reduced fall risk.

PI_NAMEs: CHRISTOU, EVANGELOS A (contact);OKUN, MICHAEL S

PROJECT_TERMS: Acoustics;Address;Affect;Age;Area;Bilateral;botulinum neurotoxin injection;Case Study;Cell Nucleus;Clinical;Clinical Research;cohort;Communication;Data;Deep Brain Stimulation;Effectiveness;electric field;Employment;Equilibrium;Essential Tremor;Exhibits;fall risk;Foundations;Future;Goals;Hand;Head;improved;Individual;innovation;Knowledge;Lead;Limb Tremors;Location;Medial;Mediating;Mental Depression;motor control;Movement Disorders;multidisciplinary;Muscle;Nerve Degeneration;neural circuit;neuroimaging;novel;Outcome;Parkinson Disease;Patients;Periodicity;Persons;Pharmaceutical Preparations;Pharmacological Treatment;Physiology;Positioning Attribute;Propranolol;Protocols documentation;Quality of life;recruit;Refractory;Severity of illness;sex;Speech-Language Pathology;Techniques;Testing;Thalamic structure;theories;Tissues;treatment choice;Tremor;Upper Extremity;Voice

PROJECT_TITLE: ADVANCING THALAMIC NEUROSTIMULATION FOR SUPPRESING ESSENTIAL VOICE TREMOR

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE (Relevance) Chlamydia trachomatis is a medically relevant pathogen that depends on host for its nutritional requirements, thus placing the pathogen in a metabolic situation that demands balanced utilization of nutrient resources. Here, we investigate how the unusual means of regulating the trp operon accomplishes this balancing act to ensure that a specific substrate is available to the other metabolic pathways that requires it. Investigations will revolve around the intergenic region of the trp operon, which was previously characterized to mediate regulation by the transcriptional repressor YtgR.

PI_NAMEs: CARABEO, REY A (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Alleles;Amino Acids;Anabolism;anthranilate;antitermination;attenuation;Bacillus subtilis;Bacteria;Binding;Biological;Biology;Biosensing Techniques;Biosensor;Blindness;Cell Differentiation process;Cells;Chimeric Proteins;Chlamydia;Chlamydia trachomatis;clinically relevant;Codon Nucleotides;Compensation;Consumption;cost;Data;Dependence;derepression;Developed Countries;Developing Countries;Development;Diphosphates;Down-Regulation;driving force;Elements;Ensure;Environment;enzyme activity;Epithelial Cells;Equity;erythrose 4-phosphate;Escherichia coli;Evolution;Female;Gene Order;Generations;Genes;Genetic;Genetic Polymorphism;Genetic Transcription;Genome;genome-wide;Genus Felis;Glutamine;Growth;human pathogen;in vivo;Indoles;inhibitor;Intercistronic Region;interest;Internet;Investigation;Iron;Kynureninase;Kynurenine;laboratory experiment;Link;Location;Mediating;Medical;Metabolic;Metabolic Pathway;metabolomics;microbiome;microbiota;Modeling;Mutation;Nutrient;Nutritional;Nutritional Requirements;Open Reading Frames;Operon;particle;pathogen;Pathway interactions;Phosphatidylethanolamine;Phosphatidylserines;Phosphoenolpyruvate;Physical condensation;prevent;Process;Production;programs;Prokaryotic Cells;promoter;Property;Protein Precursors;Reaction;receptor recycling;Regulation;Reporting;reproductive tract;Resources;Ribosomes;RNA;Role;Serine;Sexually Transmitted Diseases;Squamous Epithelium;Starvation;stem;Stratified Squamous Epithelium;Structure;TF gene;TFRC gene;Tissues;Trans-Activators;Transcription Repressor;Transcriptional Regulation;Translations;TRAP Complex;Tryptophan;Tryptophan Synthase;Work

PROJECT_TITLE: Functional relevance of C. trachomatis trp operon polymorphism

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


NIH_SPENDING_CATS: Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Mutations in equilibrative nucleoside transporter 3 (encoded by SLC29A3 gene) cause an expanding spectrum of human genetic disorders (e.g., H syndrome, PHID syndrome, and SHML/RDD syndrome) with anemia as a characteristic sign. In the present proposal we seek to determine the molecular disease pathogenesis and treatment options for anemia and related pathologies observed in SLC29A3-mutated disorders. The proposed research is relevant to public health because we anticipate that this project will uncover treatment options for several SLC29A3 mutated human disorders and improve the understanding of occurrence of anemias in humans.

PI_NAMEs: GOVINDARAJAN, RAJGOPAL  (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: 3-Dimensional;Acute;Address;Aftercare;Anemia;bile acid transporter;Bile Acids;biological adaptation to stress;Biological Models;Bone Marrow;Butyric Acids;Characteristics;Chemicals;Clinical;Cytoprotection;cytotoxic;Data;Defense Mechanisms;Disease;drug disposition;Drug Kinetics;dysosteosclerosis;endoplasmic reticulum stress;Erythroid;Functional disorder;functional improvement;Genes;Genetic;Genetic Diseases;Goals;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hepatosplenomegaly;Homeostasis;Homing;Human;Human Genetics;Image;improved;Induction of Apoptosis;Inflammasome;innovation;insight;irradiation;Knockout Mice;Lead;Link;Lysosomes;Maintenance;Mass Spectrum Analysis;Membrane;metabolic abnormality assessment;Modeling;Molecular;Molecular Chaperones;Molecular Disease;Molecular Probes;mouse model;Mus;Mutate;Mutation;Myelogenous;novel;Nucleoside Transporter;Organelles;Pathogenesis;Pathology;Pathway interactions;Patients;pharmacologic;Physiological;Property;Proteins;Public Health;Quantitative Structure-Activity Relationship;Regulation;Research;response;Role;Signal Transduction;solute;stem cell homeostasis;Stress;Structure;Syndrome;Testing;Therapeutic;Time;trafficking;Transplantation;Vesicle;Xenopus oocyte

PROJECT_TITLE: SLC29A3 lysosomal transporter in hematopoietic homeostasis and disease

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE Because social anxiety that persists into mid-adolescence predicts lifelong negative mental, social, and economic outcomes, there is a critical need to identify the behavioral and neural mechanisms by which youth remit vs. persist in symptoms. The goal of this longitudinal project is to characterize the brain-based mechanisms by which biased memory for negative social experiences contribute to adolescent social anxiety persistence and remittance. Given gold standard treatment rarely results in remission, these results will pave the way to develop much-needed novel interventions, tailored to a key period of development, that prevent devastating lifelong consequences.

PI_NAMEs: JARCHO, JOHANNA MOLLY (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Adolescence;Adolescent;Adult;Age;anxiety symptoms;Behavior;Behavioral Mechanisms;biobehavior;Brain;brain based;Brain Mapping;comorbidity;Corpus striatum structure;Coupling;critical developmental period;critical period;Data;Development;Disease remission;Dopamine;dopamine system;early adolescence;economic outcome;Event;experience;Failure;Feedback;Female;Functional Magnetic Resonance Imaging;Goals;Hippocampus;imaging modality;innovation;Intervention;Investigation;Link;Longitudinal Studies;Magnetic Resonance Imaging;Maps;Measures;Medial;Mediating;Memory;memory process;Methods;Modeling;Motivation;MRI Scans;multimodal neuroimaging;neural correlate;Neurocognitive;neuromechanism;neuromelanin;novel;Participant;Pathway interactions;peer;Persons;Phase;Play;Prefrontal Cortex;prevent;Process;Proxy;Psyche structure;Psychopathology;Quality of life;Remittance;Research;response;Role;Severities;Signal Transduction;social;social anxiety;Social Anxiety Disorder;Social outcome;standard care;Symptoms;System;Testing;theories;Time;Work;Youth

PROJECT_TITLE: Neural mechanisms of memory bias in adolescent social anxiety persistence and remittance

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Back Pain;Clinical Research;Pain Research

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative The long-term goal of this proposal is to understand better the process of intervertebral disc (IVD) maintenance to identify new strategies to prevent or treat low back pain and degenerative disc diseases. This study will characterize the putative role of TonEBP in the secretory machinery of cells forming and maintaining the different compartments of the IVDs, and define the cross-talk between these different IVD compartments required for IVD maintenance.

PI_NAMEs: ELEFTERIOU, FLORENT  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Ablation;Age;Alleles;Autocrine Communication;Autophagocytosis;Biological Assay;Breeding;Cartilage;cell behavior;Cell Enlargement;cell growth regulation;Cell Proliferation;Cell secretion;Cell Survival;Cells;Chondrocytes;Communication;comparative;Cytoplasm;Defect;Disease;Epiphysial cartilage;Equilibrium;Etiology;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Fibrocartilages;Genes;Goals;Homeostasis;Hydration status;improved;in vivo;insight;Intervertebral disc structure;intervertebral disk degeneration;Investigation;Isotonic Exercise;Knowledge;KRT19 gene;liquid chromatography mass spectrometry;loss of function;Low Back Pain;LoxP-flanked allele;Maintenance;mouse model;Mus;mutant;Mutant Strains Mice;Nature;notochord;novel;Nuclear Translocation;nucleus pulposus;Osmolar Concentration;Osmoregulation;paracrine;Paracrine Communication;Pathway interactions;Permeability;postnatal;prevent;Process;Proliferating;Protein Secretion;protein transport;Proteins;Proteoglycan;Recycling;Repression;Role;Sclerotome;Series;Signal Transduction;Signaling Molecule;Signaling Protein;solute;spine bone structure;stem;Structure;Sum;Therapeutic;Time;Tissues;trafficking;transcription factor;Trauma;Vertebral column;Vesicle;Vesicular Transport Proteins

PROJECT_TITLE: TonEBP/Nfat5, vesicular trafficking and intervertebral disc maintenance

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative This study will be the first of its kind to explore the impact of continuous theta burst stimulation (cTBS) to the intraparietal sulcus (IPS) on arousal symptoms among patients with posttraumatic stress disorder (PTSD). We will demonstrate that IPS cTBS results in significant reduction in arousal (measured by startle response) compared to sham cTBS, that IPS cTBS interacts with extinction training to further improve arousal, and that there is a dose/response effect of cTBS on arousal. We will also demonstrate that IPS cTBS significantly improves retention of extinction learning, the experimental analogue of exposure therapy.

PI_NAMEs: BROWN, LILY A (contact)

PROGRAM_OFFICER_NAME: TUMA, FARRIS KEITH

PROJECT_TERMS: active control;Address;analog;Arousal;Attenuated;attenuation;Clinical Trials;Cognitive;Cues;Data;design;Distress;Dose;efficacy evaluation;Emotional;evidence base;Evidence based practice;Expectancy;experimental study;Extinction;Failure;falls;functional MRI scan;Future;Goals;improved;intraparietal sulcus;Lead;Learning;learning extinction;Measures;Mediating;neural;Neurobiology;neuromechanism;neuroregulation;new therapeutic target;Outcome;Parietal;Participant;Patient Education;Patients;Persons;Pharmaceutical Preparations;Physiologic pulse;Population;Post-Traumatic Stress Disorders;prevent;Psychotherapy;randomized controlled design;Research;Resistance;response;Rest;Risk;Startle Reaction;stem;Stimulus;Symptoms;synergism;Testing;Training;Transcranial magnetic stimulation;Translating;Trauma;United States;Visit

PROJECT_TITLE: A mechanistic trial of the neurobiology of extinction learning and intraparietal sulcus stimulation


NIH_SPENDING_CATS: Biotechnology;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: 8. Project Narrative Genetic variants in a single gene, APOL1, contribute to the very high rate of kidney disease in African Americans and others of recent African ancestry, and also confer resistance to Sleeping Sickness in Africa. We want to understand precisely how these genetic variants lead to this major disparity in kidney disease at a biological level. Understanding how these differences in the APOL1 gene cause kidney disease will have direct implications for improving all aspects of care for the growing number people with this serious public health problem and ultimately removing a major racial health disparity.

PI_NAMEs: FRIEDMAN, DAVID J;POLLAK, MARTIN R. (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: 3' Untranslated Regions;Accounting;Africa;African American population;African ancestry;African Trypanosomiasis;AIDS-Associated Nephropathy;Alleles;American;Bacterial Artificial Chromosomes;Binding;Binding Proteins;Biological;Biological Models;Caring;Cells;Code;counterscreen;COVID-19;cytokine;Development;Disparity;Double-Stranded RNA;End stage renal failure;Endogenous Factors;Environmental Risk Factor;Enzymes;experimental study;Focal and Segmental Glomerulosclerosis;Frequencies;Gene Expression;Genes;Genetic Diseases;Genetic Polymorphism;genetic variant;Genotype;glomerulosclerosis;Health;high risk;high throughput screening;HIV;Human;Hypertension;Immune signaling;Immunity;Immunologic Factors;improved;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Response;Injury;Interferon Activation;Interferons;Kidney;Kidney Diseases;Kidney Failure;Label;Lead;Membrane;Messenger RNA;MicroRNAs;mouse model;Names;Patients;Pattern Recognition;Pattern recognition receptor;Persons;Phenotype;podocyte;prevent;Prevention;Production;protein function;Proteins;Proteinuria;Public Health;racial disparity;racial health disparity;receptor binding;Reporter;Repression;Resistance;Risk;Risk Factors;risk variant;Role;Seminal;Signal Transduction;Signaling Molecule;Stimulus;System;Testing;Therapeutic;Toxic effect;Transcript;Transgenic Mice;Untranslated Regions;Up-Regulation;Variant;Viral;Virus;Work

PROJECT_TITLE: Integrating signals that control APOL1 gene expression and drive kidney disease


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Neurosciences;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative The adult enteric nervous system contains neuronal progenitors that can be leveraged for regenerative cell therapy to treat neurointestinal diseases, but the pathways that mediate the neurogenic response in the postnatal intestine are unknown. Based on our preliminary data, we hypothesize that inflammatory mediators released by intestinal macrophages act on specific populations of enteric glial cells to activate their differentiation to a neuronal lineage. In this proposal, we will determine the role of activated macrophages and their inflammatory cytokines in glial-derived neurogenesis, examine the role of Sox2 and Sox10 transcription factors in this process, and characterize the phenotypic diversity of the glial-derived neurons that are generated.

PI_NAMEs: GOLDSTEIN, ALLAN M (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Acquired Abnormality;Acute;Adult;Affect;American;Bioinformatics;Cell Therapy;Cell Transplantation;Cells;cholinergic;Chromatin;chromatin remodeling;Chronic;Cleavage Under Targets and Release Using Nuclease;Clinical;Colitis;Congenital Abnormality;Congenital Megacolon;Constipation;cytokine;Data;Development;dextran sulfate sodium induced colitis;Disease;Enteral;Enteric Nervous System;enteric neuropathy;Environment;Epigenetic Process;epigenomic profiling;Esophageal achalasia;experimental study;Extracellular Matrix;Family;Functional Gastrointestinal Disorders;Ganglia;gastrointestinal;Gastrointestinal Diseases;gastrointestinal function;Gastrointestinal tract structure;Gastroparesis;Gene Expression;Gene Expression Profile;Gene Expression Profiling;gene repression;Gene Silencing;Genes;Genetic;genomic locus;Glial Differentiation;gut homeostasis;gut inflammation;Health;Health Care Costs;Human;Immunity;Immunologic Tests;implementation barriers;improved;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Bowel Diseases;innovation;Intestinal Pseudo-Obstruction;Intestines;Irritable Bowel Syndrome;Knowledge;Lead;Macrophage;Mediating;Methods;Molecular;Morbidity - disease rate;Motility;motility disorder;multiple omics;Mus;nerve stem cell;nerve supply;nervous system development;neurogenesis;Neuroglia;Neuronal Differentiation;Neurons;Neuropathy;Neurosphere;new therapeutic target;Pathway interactions;Patients;Phenotype;Population;postnatal;prevent;Process;Production;progenitor;programs;protein expression;Quality of life;receptor;regeneration potential;regenerative cell;Regulation;Regulatory Element;Repression;response;restraint;Role;Signal Transduction;stem cell biology;Stimulus;Techniques;Testing;transcription factor;Transplantation;transplantation therapy;Up-Regulation

PROJECT_TITLE: Characterizing neurogenic progenitors in the adult intestine


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative This project is aimed to explore the mechanisms underlying increased risk of atherothrombosis driven by LNKW262R, a common genetic polymorphism that is associated with increased cardiovascular events, using both animal models and human blood cells.

PI_NAMEs: WANG, NAN  (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Acceleration;Address;African American population;Alleles;Animal Model;Antibodies;Atherosclerosis;atherothrombosis;Blood;Blood Cells;Blood Platelets;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cells;Cholesterol;Cytokine Signaling;Data;Dendritic Cells;Development;eosinophil;Eosinophilia;European;Event;extracellular;Genetic;Genetic Polymorphism;genome wide association study;Goals;Hematopoietic;Human;human induced pluripotent stem cells;hypercholesterolemia;improved;In Vitro;Latin American;Leukocytes;LoxP-flanked allele;Macrophage;Mediating;metabolic phenotype;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;Mus;Myelopoiesis;neutrophil;Neutrophil Activation;novel;novel therapeutic intervention;Phospholipids;Play;Population;Probability;Production;progenitor;Risk;Risk Factors;Role;Thrombosis;Thrombus;Variant;Venous Thrombosis

PROJECT_TITLE: The role of eosinophil in thrombosis and atherosclerosis in LNK deficiency

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: INDIANAPOLIS

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE This proposed research is relevant to public health because understanding the mechanisms by which microbiota impact mucosal immune function in a highly prevalent disease such as chronic rhinosinusitis (CRS) will lead to: (1) more judicious use of antibiotics, (2) clarity of microbial targets for sinus health and disease, (3) better understanding of therapeutic interventions as they relate to the microbiome, and (4) elucidation of how airway surface microbiota are regulated. Incorporation of these findings into clinical management paradigms will result in well-defined CRS endotypes, improve prognostic abilities for existing interventions, and direct development of novel therapeutics. The proposed research is relevant to NIH's mission for fundamental knowledge that enhances health, reduces illness and disability, and enhances quality of life.

PI_NAMEs: FRANK, DANIEL N;RAMAKRISHNAN, VIJAY  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Activities of Daily Living;Address;Affect;Algorithms;Anti-Inflammatory Agents;Antibiotics;antimicrobial;Attenuated;Cell Culture Techniques;cell type;Chronic;Chronic Disease;Chronic Obstructive Pulmonary Disease;chronic rhinosinusitis;Clinical;Clinical Management;clinical phenotype;clinical practice;Communicable Diseases;Communities;Congestive Heart Failure;conventional therapy;cost;Data;Development;disability;Disease;Disease Management;Disease Outcome;dysbiosis;End stage renal failure;Epithelial Cells;Epithelium;Etiology;Functional disorder;Goals;Health;High Prevalence;Homeostasis;host microbiome;host-microbe interactions;Human;human tissue;Immune;immune function;Immunologics;Impairment;improved;In Vitro;Inflammation;Inflammatory;innovative technologies;insight;Institution;Integration Host Factors;Intervention;Intervention Studies;Kidney Diseases;Knowledge;Laboratories;lipidome;Lipids;Lipoxins;Measures;Mediating;Mediator;Medical Care Costs;metabolome;Microbe;microbial;microbial host;microbiome;microbiome alteration;microbiome research;microbiota;Mission;Molecular;Molecular Disease;Mucosal Immunity;Mucositis;Mucous Membrane;multiple omics;nasal microbiota;Nature;novel;novel therapeutics;Onset of illness;Operative Surgical Procedures;Organism;Outcome;pathogen;Patients;Phenotype;Population;Process;Prognosis;prognostic value;programs;Pseudomonas aeruginosa;Public Health;Publications;Publishing;Quality of life;Refractory;Research;Resolution;respiratory microbiota;response;restoration;Role;Sampling;Science;Severities;Severity of illness;Sinus;Specimen;Staphylococcus aureus;Surface;Systems Biology;Testing;Therapeutic;Therapeutic Intervention;therapy outcome;Tissues;transcriptome;Translating;treatment response;treatment strategy;United States National Institutes of Health

PROJECT_TITLE: CRS Microbiome: Multi-omic Integrative Longitudinal Experimental (CRS-MILE) study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-U (90)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_NAME: BOSTON VA RESEARCH INSTITUTE, INC.

PHR: PROJECT NARRATIVE Frailty is a syndrome increasingly common in older adults that makes it difficult to recover from a stressful event, such as an infection or fall, and increases the need for more help at home or long-term institutionalization. We believe that statins, one of the most common medications to lower cholesterol and prevent heart disease and strokes, may have a role in lowering frailty by lowering inflammation. In this study we will test whether statins can lower the risk of frailty, measured according to several physical function parameters such as walk speed and grip strength, common blood tests, and other health variables.

PI_NAMEs: ORKABY, ARIELA R (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Adult;Affect;Age;age group;age related chronic disease;aged;Aging;aging related;Ancillary Study;atorvastatin;Basic Science;Biological Aging;Biological Markers;Blood;Blood specimen;Blood Tests;Body Weight decreased;Cardiovascular Diseases;cardiovascular disorder prevention;Cessation of life;Cholesterol;Chronic Disease;Clinical;Clinical Trials;Cognition;Complement;cost effective;Data;Dementia;Development;disability;Disability outcome;Elderly;Evaluation;Event;exhaustion;falls;Fatigue;follow-up;frailty;FRAP1 gene;Functional disorder;Funding;Gait speed;Geroscience;hallmarks of aging;Hand Strength;Health;healthy lifestyle;heart disease prevention;Home;human old age (65+);indexing;Infection;Inflammation;inflammatory marker;Infrastructure;Institutionalization;Intervention;Laboratories;Lipids;Measures;Mediating;Molecular;Morbidity - disease rate;Nerve Degeneration;older adult;Paint;Parents;Participant;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Physical activity;Physical Function;Physical Performance;Physiological;Placebos;Population;prevent;Prevention;primary outcome;Process;prospective;Protocols documentation;Questionnaires;Randomized;Recommendation;Records;Resources;Risk;Role;senescence;Stressful Event;Stroke;Subgroup;survival outcome;Syndrome;Testing;theories;Time;trend;Veterans;Visit;Walking;walking speed;Woman;Women's Health;Work

PROJECT_TITLE: PREVENTABLE Frailty Ancillary Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ASG-B (90)]


NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases;Liver Disease;Organ Transplantation;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation;Wound Healing and Care

ORG_CITY: BALTIMORE

ORG_DEPT: SURGERY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: A breakthrough to achieve regeneration of perfect skin has become a major aim in wound healing especially for large burns. The goal of this proposal is to understand the mechanisms of skin regeneration through repopulation of skin allografts in small animal models and to demonstrate the efficacy and feasibility of our novel stem cell mobilizing therapy in repopulation of skin allografts in a preclinical large animal (swine) model of full thickness burns. The translational outcome of this proposal will be a simple, safe and clinically pertinent protocol using FDA approved drugs to induce skin regeneration and to improve the treatment of victims of severe burns.

PI_NAMEs: SUN, ZHAOLI  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Acceleration;Affect;Age;allograft rejection;Allografting;AMD3100;analog;Animal Model;Animals;antagonist;Architecture;Binding;Biological;Blood Cells;Bone Marrow;Bone Marrow Stem Cell;Burn injury;burn model;burn therapy;burn wound;Cells;Child;Chimerism;Cicatrix;Clinical;clinical trial protocol;Combined Modality Therapy;Contracture;conventional therapy;Cosmetics;Critical Illness;CXCR4 gene;Defect;design;donor stem cell;dosage;Dose;Down-Regulation;Drug Combinations;efficacy testing;Engineering;Environment;Family suidae;FDA approved;FK506;Freedom;Gene Modified;Gene set enrichment analysis;genome-wide;Goals;Hair follicle structure;healing;HIV;HLA Antigens;Hospitalization;Human;Immune response;immune tolerance/unresponsiveness;Immunologics;Immunosuppression;Immunosuppressive Agents;improved;In Situ;Infection;infection risk;Injury;Kidney;kidney allograft;Legal patent;Liver;liver allograft;Macrophage;Medicine;Metabolic stress;Miniature Swine;Modeling;Modernization;Molecular;Morbidity - disease rate;mortality;Mus;Natural regeneration;novel;novel therapeutics;organ transplant recipient;organ transplant rejection;Organ Transplantation;Outcome;Pain;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase I Clinical Trials;Physiological;Pilot Projects;Population;porcine model;pre-clinical;Predisposition;prevent;Process;Protocols documentation;psychologic;Quality of life;Rattus;recruit;Repeat Surgery;response;restoration;Rodent;Safety;scaffold;severe burns;Site;Skin;skin allograft;Skin graft;skin healing;skin regeneration;Skin Transplantation;Skin wound healing;Solid;Source;Stem Cell Mobilization;stem cells;Stromal Cell-Derived Factor 1;synergism;Testing;third degree burn;Time;transcriptome;transcriptome sequencing;transplant model;Work;wound;wound closure;wound healing;Wound Infection

PROJECT_TITLE: In Situ Skin Regeneration through Induction of Skin Allograft Chimerism for Treatment of Severe Burn Wounds

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: Brain injury caused by blast waves from IEDs (improvised explosive devices) and other explosions is a signature injury of Veterans serving in Iraq and Afghanistan over the past 20 years. This form of brain injury can result in mental health problems such as PTSD-like symptoms and impairments in brain function (memory loss and/or difficulty making appropriate decisions). These consequences of blast wave injury to the brain seem to result from low-grade chronic inflammation and progressive injury to brain cells. The research described in this application will test whether inhibitors of inflammation can prevent behavioral changes resulting from blast exposure in a well-established a rat model of the anxiety-like traits and brain dysfunction typical of brain injury caused by exposure to blast waves. The treatment being tested can be taken by mouth, is present in nutritional supplements, and is thus thought to be safe. Thus, if successful, this research could be rapidly translated to Veterans to attempt to reduce neuropsychiatric complication of blast exposures.

PI_NAMEs: CARDOZO, CHRISTOPHER P (contact)

PROJECT_TERMS: Acceleration;Acoustics;Address;Afghanistan;Alkaloids;Animals;Anti-Inflammatory Agents;Antioxidants;Anxiety;Appearance;Astrocytes;Behavior;Behavioral;behavioral phenotyping;Binding;blast exposure;Blast Injuries;Blood Vessels;Brain;brain cell;brain dysfunction;Brain Injuries;Cell membrane;Cell surface;Cells;Central Nervous System;channel blockers;Chilean;Chronic;clinically relevant;Cognition;Cognitive;cognitive change;cohort;Complication;Connexin 43;Connexins;Cues;Data;decubitus ulcer;Development;Devices;dietary supplements;differential expression;Elderly;Experimental Models;Explosion;Exposure to;Fright;Functional disorder;Gap Junctions;Genes;Glutamates;Goals;Herbal remedies;Impaired cognition;Impairment;improved;Inflammasome;Inflammation;Inflammatory;inhibitor;Injury;Ion Channel;Iraq;Learning;Link;Long-Evans Rats;Membrane;Memory Loss;Mental Depression;Mental disorders;Mental Health;Microglia;mild traumatic brain injury;Modeling;Modernization;Molecular;motor function improvement;Mus;Nerve Degeneration;neurobehavioral;neuropsychiatric symptom;neuropsychiatry;NF-kappa B;novel;novel therapeutics;object recognition;operation;Oral;Oral Administration;Oral cavity;Pathology;Peumus boldus;pharmacologic;Phenotype;Post-Traumatic Stress Disorders;prevent;Property;Randomized;Rattus;Research;Risk;RNA;Signal Transduction;Spinal cord injury;stress related disorder;suicidal risk;Supportive care;Symptoms;Syndrome;Testing;Time;Tissues;TNF gene;trait;transcriptomics;Translating;Translations;Traumatic Brain Injury;Trees;United States Department of Agriculture;vascular inflammation;Veterans

PROJECT_TITLE: Non-selective membrane channel blockers for mTBI

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]