NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Complementary and Integrative Health;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: BILLHEIMER, DEAN  (contact)

PROJECT_TERMS: Affect;Air Pollution;Airborne Particulate Matter;Area;Aridity;Arizona;Basic Science;beneficiary;Bioinformatics;Biometry;career development;Cell model;cellular imaging;climate change;Clinical;Clinical Research;Collaborations;Communication;Communities;community engaged research;community engagement;community partners;Consultations;Core Facility;cultural competence;data management;Data Science;data science resource;Databases;design;Development;Disease;disease model;Education;Ensure;Environment;Environmental Exposure;Environmental Health;Environmental Risk Factor;environmental stressor;Experimental Models;experimental study;exposed human population;Exposure to;Fire - disasters;Focus Groups;Fostering;Funding;Goals;Health;health literacy;Health Policy;health science research;Health Sciences;High Performance Computing;Human;Human Resources;human subject;Informatics;Inhalation Exposure;innovation;Integrative Medicine;Leadership;Lung Diseases;Measurement;Mentors;Metals;Mission;Modeling;Names;Organic solvent product;Outcome;Participant;Persons;Pilot Projects;Plasticizers;Poly-fluoroalkyl substances;Population;Population Heterogeneity;Population Research;Population Study;Program Development;programs;Public Health;public health intervention;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;response;Risk;Rodent;Rodent Model;Sampling;Scientist;Services;Smoke;Statistical Computing;Statistical Data Interpretation;Statistical Models;statistics;stem;Stress;Surveys;Technology;Toxicology;training opportunity;translational health science;Translational Research;Ultraviolet Rays;Work

PROJECT_TITLE: Integrative Health Sciences Facility Core


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurosciences;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

ORG_CITY: STORRS-MANSFIELD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: A multiphase optimization strategy (MOST) will be used to conduct an optimization trial among people who inject drugs (PWID) and are newly enrolled on medication for opioid use disorder (MOUD). We will assess the impact and cost of four promising intervention components (Attention, Executive Functioning, Memory, and Information Processing). The components are designed to accommodate cognitive dysfunction such that participants can better process and utilize intervention content, thus leading to enhanced PrEP adherence and HIV risk reduction.

PI_NAMEs: COPENHAVER, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;AIDS prevention;Alzheimer's Disease;American;Analgesics;Area;Attention;Attention deficit hyperactivity disorder;Behavior;Behavioral;Budgets;Characteristics;Cognitive;Cognitive deficits;cognitive function;cognitive testing;Communities;comorbidity;Compensation;cost;cost effectiveness;Dementia;design;Disease Outbreaks;Enrollment;evidence base;Evidence based intervention;executive function;Exhibits;experience;follow-up;Friends;frontier;Funding;Funding Opportunities;future implementation;Goals;Guidelines;Health;Health behavior;Health behavior change;Health Promotion;high risk population;HIV;HIV Infections;HIV risk;HIV/AIDS;Impaired cognition;improved;Incidence;Individual;information processing;Injectable;Injecting drug user;innovation;Intervention;Knowledge;Measurement;Measures;Mediator;medication compliance;medication for opioid use disorder;memory process;Methods;Modeling;Motivation;multiphase optimization strategy;Neurologic;Opioid;opioid epidemic;opioid use disorder;Outcome;overdose death;Participant;patient population;Patient Self-Report;Patients;Performance;Persons;Pharmaceutical Preparations;Pharmacotherapy;post intervention;pre-exposure prophylaxis;prevent;Prevention approach;primary outcome;Process;programs;Public Health;Recovery;Research;Research Priority;response;Risk Behaviors;Risk Reduction;Risk Reduction Behavior;Science;secondary outcome;sex;skills;Study models;transmission process;Traumatic Brain Injury;treatment program;treatment services;trend;United States National Institutes of Health;Update;Volatilization;Work

PROJECT_TITLE: Optimizing evidence-based HIV prevention targeting people who inject drugs on PrEP

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: PISCATAWAY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project narrative. RNA is an intermediary molecule that transmits genetic information encoded in DNA and the precise regulation of its decay is critical for normal cellular homeostasis and RNA therapeutics. Our identification of novel elements and factors that control RNA decay will be instrumental in understanding the molecular underpinnings of gene expression. This work will provide insight into a fundamentally new mode of controlling RNA metabolism and provide a framework for previously unknown approaches of modulating gene expression in normal and disease states.

PI_NAMEs: KILEDJIAN, MEGERDITCH  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Adenine;Cells;clinical phenotype;Diphosphates;Disease;DNA;Elements;Excision;Flavin-Adenine Dinucleotide;Gene Expression;Gene Silencing;genetic information;Guanosine;Homeostasis;Individual;insight;Link;Messenger RNA;Metabolism;Minor;Molecular;mRNA Stability;Niacinamide;novel;Nucleotides;Physiological;Regulation;RNA;RNA Caps;RNA Decay;RNA metabolism;RNA Stability;therapeutic RNA;Translations;transmission process;Uridine Diphosphate N-Acetylglucosamine;Work

PROJECT_TITLE: 5’ end RNA Caps in Gene Expression

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biomedical Imaging

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PI_NAMEs: CHERRINGTON, NATHAN J (contact)

PROJECT_TERMS: Address;Analytical Chemistry;animal imaging;Applications Grants;Aridity;Arizona;Biochemical;biomedical imaging;Cells;cellular imaging;climate change;Computers and Advanced Instrumentation;Consult;Core Facility;cost;cost effective;Data;data acquisition;Data Analyses;Data Collection;data submission;Disease;Educational workshop;Electrons;Ensure;Environmental Health;Equipment;experience;Experimental Designs;Exposure to;Fluorescence;Funding;Goals;histological image;Human Resources;Image;imaging facilities;Imaging Techniques;In Situ;innovation;Institution;instrument;instrumentation;Light;Manuscripts;member;Microscopic;Microscopy;Mission;Molecular;Molecular Biology;Morphology;Nomarski Interference Contrast Microscopy;novel;Pathologic;Peer Review;Persons;Phase;Preparation;Procedures;Research;Research Personnel;Resources;Risk;Secure;Services;Site;Structure;Students;Technical Expertise;Techniques;Tissues;Toxic Environmental Substances;toxicant;Training;Universities;Visualization;Writing

PROJECT_TITLE: Cellular Imaging Facility Core

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Pancreatic cancer is the third leading cause of cancer deaths in the U.S. with 57,600 new pancreatic cancer cases anticipated in 2020 resulting in a projected >$3 billion burden to the healthcare system. The dismal five year survival rate of just 10% for pancreatic cancer patients is due in large part to ineffective drug targets for highly complex and desmoplastic tumors of pancreatic cancer. This project has high translational value as it seeks to develop more effective anti-cancer agents targeting the cancer even within the protective stroma using sophisticated in vitro and in vivo model systems that will contribute to the goal of increasing pancreatic cancer patient survival.

PI_NAMEs: FISHEL, MELISSA L. (contact);HAN, BUMSOO

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: 3-Dimensional;Ablation;Acceleration;Address;Affect;analog;Antineoplastic Agents;Biological Models;cancer cell;Cancer Cell Growth;cancer clinical trial;Cancer Etiology;cell killing;Cell Survival;Cells;Cessation of life;Characteristics;Chemicals;Clinical;Coculture Techniques;Complex;Critical Pathways;Data;Desmoplastic;DNA Binding;Drug Kinetics;Drug resistance;Drug Targeting;effective therapy;Effectiveness;efficacy evaluation;efficacy validation;Evaluation;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Foundations;gemcitabine;Generations;Goals;Growth;Healthcare Systems;Heterogeneity;Human;Impairment;improved;In Vitro;in vivo;in vivo Model;inhibitor;insight;Invaded;Investigation;Liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolism;Microfluidics;Microsomes;Modeling;Molecular Target;Mus;Neoplasm Metastasis;neoplastic cell;NF-kappa B;novel;Outcome;Oxidation-Reduction;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathway interactions;Patients;Pharmacodynamics;pharmacologic;Phase;phase I trial;Proliferating;Role;screening;Signal Pathway;Signal Transduction;Signaling Protein;spheroids;STAT3 gene;Survival Rate;System;targeted agent;Therapeutic;three-dimensional modeling;Tissues;Toxic effect;transcription factor;Transcription Factor AP-1;Translating;Translations;Treatment Efficacy;Treatment outcome;treatment response;Triage;tumor;tumor growth;tumor microenvironment

PROJECT_TITLE: Investigation of novel signaling protein in 3D and in vivo PDAC models using second generation Ref-1 inhibitors

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Radiation Oncology

ORG_CITY: IOWA CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Peptide receptor radionuclide therapy (PRRT) with [177Lu]DOTATATE improves quality of life and survival in patients with advanced neuroendocrine tumors; however objective tumor regression is infrequent and complete responses are exceedingly rare. On the other hand, exciting-emerging evidence suggests that PRRT with alpha-emitters has the potential to extend PRRT to tumor regression and even complete response. In this study we propose to develop a new theranostic pair using [203Pb]PSC-TOC (imaging) / [212Pb]PSC-TOC (alpha emitter) for image-guided dosimetry based personalized therapy for neuroendocrine tumors.

PI_NAMEs: MENDA, YUSUF  (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: 90Y;Alpha Particle Emitter;Alpha Particles;Amino Acids;Animals;Biological Markers;Blood;Bone Marrow;Chelating Agents;Clinical;clinical practice;Clinical Research;Clinical Trials;cohort;Computer software;Data;Data Analyses;Dependence;Detection;Diagnosis;Dose;Dose Limiting;dosimetry;Drug toxicity;effective therapy;efficacy trial;Elements;Female;Histologic;Human;human imaging;human subject;Image;image guided;imaging study;Immunocompetent;improved;improved outcome;In complete remission;Incidence;Infusion procedures;Injury;Isotopes;Kidney;Label;Letters;Literature;male;Marrow;Measurement;Measures;Metastatic Neoplasm to the Liver;Methodology;mouse model;Multi-Institutional Clinical Trial;multi-site trial;Mus;Neuroendocrine Tumors;Organ;Outcome;Patient Selection;Patient-Focused Outcomes;Patients;Peptide Receptor;Peptides;Performance;personalized medicine;PET/CT scan;phantom model;Phase;Phase I Clinical Trials;phase III trial;Positioning Attribute;pre-clinical;preclinical toxicity;predictive modeling;Preparation;Procedures;Production;Protocols documentation;Quality of life;Radiation Dose Unit;Radiolabeled;Radiometry;Radionuclide therapy;Radiopharmaceuticals;Randomized;reduce symptoms;Refractory;Research;residence;response;Running;Safety;serial imaging;Serum;single photon emission computed tomography;standard of care;Study models;Systemic Therapy;theranostics;Therapeutic;Therapy trial;Time;Toxic effect;Translations;tumor;urinary;Validation;Work;X-Ray Computed Tomography

PROJECT_TITLE: Alpha-Particle Emitter Peptide Receptor Targeted Radionuclide Therapy for Neuroendocrine Tumors

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PI_NAMEs: WATTS, GEORGE S (contact)

PROJECT_TERMS: Address;Air;Applications Grants;Aridity;Arsenic;Awareness;Biological;Biological Markers;Budgets;Chemicals;Computers and Advanced Instrumentation;Consult;Consultations;Core Facility;cost effective;cost efficient;Data;Data Analyses;Dideoxy Chain Termination DNA Sequencing;Disease;Disulfide Linkage;DNA Methylation;DNA sequencing;Dust;Ensure;Environmental Health;epigenome;epigenomics;Equipment;equipment acquisition;exome;experience;Experimental Designs;experimental study;Genome;Genomics;Genotype;Goals;health science research;Health Sciences;Histones;Individual;Industrialization;Information Dissemination;innovation;insight;Institution;instrumentation;Investments;Laboratories;Lead;Logistics;Manuscripts;Maps;Mass Spectrum Analysis;Measurement;Measures;member;Mercury;metabolome;metabolomics;Metals;Methods;Mission;Modeling;Modernization;monomethylarsonic acid;Peptides;Persons;pilot test;Plants;Population;Post-Translational Protein Processing;Preparation;Process;Proteins;Proteome;Proteomics;Quality Control;Research;Research Design;Research Personnel;Resources;Reverse Transcriptase Polymerase Chain Reaction;Risk;Sampling;Scientist;Secure;Services;Site;Students;Teacher Professional Development;technique development;Techniques;Technology;technology/technique;Time;Tissues;Toxic Environmental Substances;toxicant;Training and Education;transcriptome;transcriptome sequencing;Trichloroethylene;Universities;Vision;Water;whole genome

PROJECT_TITLE: Integrative Omics Facility Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Hydrocephalus;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: DETROIT

ORG_DEPT: NEUROSURGERY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE  Hydrocephalus is a disorder causing excess accumulation of cerebrospinal fluid in the brain, treated by using shunts to divert cerebrospinal fluid out of the cranial cavity. Our team of bioengineers, neurosurgeons, and experts in neurophysiology and biostatistics will identify patient subpopulations which correlate with a high degree of contact between the shunt catheter and tissue; then, we identify the conditions in which cause obstruction by this tissue being mechanically pulled in or biochemically grown in. By studying correlations in the patient population and causations using a benchtop model, we embrace a multi-disciplinary approach that will provide a better understanding of the mechanisms leading to shunt failure so that we can inhibit that response from occuring.

PI_NAMEs: HARRIS, CAROLYN A (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: absorption;Address;Area;Astrocytes;Attenuated;Awareness;biobank;Biochemical;Biological Factors;Biomedical Engineering;Biometry;Brain;Caring;Catheters;Cell Culture Techniques;cell growth;Cell-Matrix Junction;Cells;Cephalic;Cerebral Ventricles;Cerebrospinal Fluid;cerebrospinal fluid flow;Chemicals;Childhood;Clinical;Clinical Data;clinically relevant;clinically significant;common treatment;Correlation Studies;cytokine;Data;design;Devices;Diagnosis;Disease;Drainage procedure;Ependyma;Etiology;Event;experience;Failure;Future;Genetic Diseases;Goals;Growth;Hydrocephalus;improved;In Vitro;in vitro Model;individualized medicine;Inflammatory;interdisciplinary approach;Liquid substance;Location;Macrophage;Magnetic Resonance Imaging;Measurement;Measures;Mechanics;Meningitis;migration;Minor;Modeling;Modification;Natural Immunity;Neuroendoscopy;Neuroglia;Neurologic;Neurologic Deficit;neurophysiology;Neurosurgeon;Obstruction;Patient Care;patient population;patient subsets;Patients;Pattern;Performance;Persons;Pharmaceutical Preparations;Physiological;pressure;prevent;Prevention strategy;Process;Production;Proliferating;Publishing;Quality of life;Records;Reporting;response;Shunt Device;Source;Stroke;Structure of choroid plexus;Subarachnoid Hemorrhage;Surface;System;Testing;Thick;Time;Tissues;TLR4 gene;Traumatic Brain Injury;Treatment Protocols;tumor;United States;Variant;Ventricular

PROJECT_TITLE: Investigating the source and the action behind shunt obstruction in the treatment of pediatric hydrocephalus

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: OVERALL – NARRATIVE This Project Program Grant proposal aims to advance our knowledge of “sex as a biological variable” in bladder cancer—globally one of the top cancers that disproportionately affects males more than females. Our proposal is the only nationwide coordinated multi-investigator effort focused on uncovering the biological mechanisms that drive sex-related biology in bladder cancer. Successful completion of the proposal will offer novel biological insights that lay the foundation for therapeutic strategies that account for a patient’s sex while improving efficacy of existing treatments such as immune checkpoint blockade therapy.

PI_NAMEs: LI, XUE SEAN (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: Affect;Anatomy;Androgen Receptor;Androgens;Applications Grants;Automobile Driving;B-Lymphocytes;Benchmarking;Biological;biological sex;Biology;Bladder;Bladder Neoplasm;Cancer Biology;Cancer Center;cancer initiation;Cancer Patient;cancer therapy;cancer type;CD8-Positive T-Lymphocytes;chromosome Y loss;Chromosomes;Clinical;clinical development;Clinical Management;Collaborations;Communication;Comprehensive Cancer Center;computerized data processing;Consultations;Data;data integration;data repository;Data Science Core;design;Development;digital pathology;Disease;Disproportionately impacts women;Doctor of Philosophy;druggable target;Environmental Risk Factor;Epigenetic Process;epigenome;Estrogens;exhaustion;expectation;experience;Experimental Designs;Female;Foundations;functional genomics;Gene Targeting;Genetic;Genetic Transcription;Goals;Gonadal Steroid Hormones;Growth;Hormonal;Image Analysis;immune checkpoint blockade;Immunity;Immunocompetent;Immunologic Monitoring;Immunologics;Immunology;improved;Incidence;Infection;innovation;insight;Institution;interest;Joints;Knowledge;Laboratories;Link;male;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Medical center;Medical Oncology;Medicine;men;Molecular;mortality;mouse model;Mus;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;novel;occupational hazard;Ohio;Paper;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Physicians;Play;Prevalence;Program Research Project Grants;programs;Publications;Publishing;Receptor Signaling;Recording of previous events;Reporting;Research;Research Personnel;Resistance;Resource Sharing;response;Risk Factors;Role;Science;Services;sex;sex as a biological variable;Sex Bias;Sex Chromosomes;Sex Differences;sex disparity;Signal Transduction;Smoking;success;symposium;System;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;Time;translational potential;treatment response;tumor;tumor growth;tumor immunology;tumor initiation;tumor microenvironment;tumor progression;Tumor Suppression;Tumor Suppressor Proteins;tumor-immune system interactions;tumorigenesis;Universities;Urology;women patients;X Chromosome;Y Chromosome

PROJECT_TITLE: Sex, Chromosomes, and Immunity in Bladder Cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Estrogen;Genetics;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Urologic Diseases

PHR: PROJECT 1 – NARRATIVE It is unclear why men develop many cancers (such as bladder cancer) more often than women, even after adjusting for known risk factors such as smoking. We discovered that dysfunction within the adaptive T cell immune response strongly contributes to male-biased tumor aggressiveness; this dysfunction is modulated by male hormones that reduce the anti-tumor response in T cells. The goal of this project is to characterize the sex- specific differences in T cell response to tumors and use this knowledge to improve cancer immunotherapy in both men and women.

PI_NAMEs: LI, ZIHAI  (contact)

PROJECT_TERMS: Adopted;Aggressive behavior;androgen deprivation therapy;Androgen Receptor;Androgens;anti-PD-1;anti-PD1 therapy;Antitumor Response;Biological;cancer immunotherapy;Cancer Model;cancer subtypes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Proliferation;Cell Survival;cell type;Cellular biology;chromosome Y loss;Chromosomes;Chronic;Collaborations;Data;effector T cell;Environment;Epigenetic Process;exhaust;exhaustion;Female;Frequencies;Functional disorder;gene network;Genes;Genetic Transcription;Goals;Gonadal Steroid Hormones;Hormones;Immune;immune checkpoint blockade;Immune Evasion;immune function;Immune response;Immunity;Immunologics;Immunology;Immunotherapy;improved;In Vitro;in vivo;Incidence;Knowledge;Link;male;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;men;Molecular;Molecular Target;Mus;nuclear factors of activated T-cells;Organ;Population;Production;progenitor;Prognosis;programs;Proteins;Publishing;Receptor Signaling;Rejuvenation;Reporting;response;Risk Factors;Role;Science;sex;Sex Bias;Sex Chromosomes;Sex Differences;sexual dimorphism;Signal Transduction;single-cell RNA sequencing;Smoking;T cell differentiation;T cell response;T-Cell Receptor;T-Lymphocyte;transcription factor;tumor;tumor microenvironment;tumor progression;Tumor-Infiltrating Lymphocytes;Woman;Work;Zinc Fingers

PROJECT_TITLE: Sexual Dimorphism in T Cell Exhaustion and Bladder Cancer


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: BEAMER, PALOMA I (contact)

PROJECT_TERMS: Address;Affect;Alcohol consumption;Aridity;Arsenic;Autoimmune Diseases;Automobile Driving;Awareness;Back;career;climate change;Communication;Communities;community engaged research;community engagement;community living;Critical Thinking;decision-making capacity;design;Diabetes Mellitus;drinking water;dust storms;Education;Educational process of instructing;Educational workshop;effectiveness evaluation;Ensure;environmental disparity;Environmental Exposure;Environmental Health;environmental health disparity;Environmental Impact;environmental justice;Evaluation;Event;experience;Exposure to;extreme heat;Feedback;forest fires;Funding;Future;Goals;Government Agencies;Health;health equity;health inequalities;health knowledge;health literacy;Health Professional;Home;Human;improved;Indigenous;information organization;interest;Internships;Journals;junior high school;Justice;Knowledge;knowledge of results;Latinx;Latinx population;Life Style;Malignant Neoplasms;meetings;member;Misinformation;Mission;Modeling;Modernization;Multilingualism;National Institute of Environmental Health Sciences;next generation;Obesity;Pesticides;Policy Maker;pollutant;Poly-fluoroalkyl substances;Population;program dissemination;programs;Public Health;Reporting;reproductive system disorder;Research;research data dissemination;Research Personnel;Research Priority;Respiratory Disease;Risk;Risk Factors;Role;Rural Community;Rural Population;Safety;Science;Scientific Advances and Accomplishments;Scientist;Self Determination;skills;Smoke;Smoking;social media;tool;toxicant;Training;Translating;tribal Nation;undergraduate student;Underserved Population;Vision;Water Pollutants;web site;Work;Youth

PROJECT_TITLE: Community Engagement Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: TUSCALOOSA

ORG_NAME: ALABAMA FIRE COLLEGE

ORG_STATE: AL

PHR: AFC Project Narrative The Workplace Safety Training Program of the Alabama Fire College proposes to provide training to Native American and public sector emergency response personnel that will prepare them to safely respond to hazardous materials releases resulting from transportation and industrial incidents, natural and manmade disasters, and illicit drug use and manufacture. Both target populations are charged with responding to such emergencies by Environmental Protection Agency, Occupational Safety and Health Administration, Department of Transportation, and Department of Homeland Security regulations, but do not have sufficient budgets and resources to provide such training. The proposed project will bring critical training to over 6,400 responders in both populations that will help them to better protect themselves and the communities they serve.

PI_NAMEs: KRAYER, THEODORE HENRY;OLDFIELD, KENNETH  (contact)

PROGRAM_OFFICER_NAME: BEARD, SHARON

PROJECT_TERMS: Accidents;Air;air monitoring;Alabama;Alaska;American;Area;Back;Budgets;Bureau of Indian Affairs;Charge;Chemicals;college;Communities;Confined Spaces;Dangerousness;Disasters;Educational process of instructing;Emergency Medical Technicians;Emergency response;Emergency Situation;Employee;Employment;empowerment;Environment;Event;Exposure to;Face;Fire - disasters;fire fighter;Fishes;Florida;Funding;Goals;hazard;hazardous materials disaster;Hazardous Substances;Hazardous Waste;Health;Hour;Human Resources;illicit drug use;Illicit Drugs;Industrialization;instructor;Law Enforcement;Leadership;Location;Louisiana;man-made disasters;manufacture;mass casualty;Measures;Medical;member;Mississippi;Modeling;National Institute of Environmental Health Sciences;Native American Tribe;Native Americans;North Carolina;Occupational;Occupations;outreach;Paramedical Personnel;peer;peer support;Police;Population;programs;Provider;Public Sector;Railroads;Readiness;Recording of previous events;Regulation;remediation;Resources;response;Rights;Risk;Running;Safety;Schedule;Security;severe weather;Societies;South Carolina;statistics;System;Target Populations;Tennessee;Terrorism;Trainers Training;Training;Training Programs;Transportation;Triage;tribal member;Tribes;United States Environmental Protection Agency;United States Occupational Safety and Health Administration;Work;Workplace

PROJECT_TITLE: AFC Hazardous Materials Worker Training


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: Nashville

ORG_DEPT: PSYCHOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE  Self-disturbances and social impairment are two core features of schizophrenia that contribute to the heavy personal and societal burden of long-term disability, but there are currently no effective interventions to ameliorate social deficits or self-disturbances of schizophrenia despite their detrimental impact on functional outcome.  We will examine a quantifiable component of self-disturbances (self-other boundary) in relation to interpersonal distance regulation by implementing multisensory integration tasks in an immersive virtual reality environment and by utilizing functional neuroimaging to characterize underlying mechanisms that may lead to anomalous self-other processing and social disconnection.  Elucidating how maladaptive social interactions may arise from basic problems of multisensory integration (i.e. disrupted self-other boundary) could lead to a more precise treatment targets, and therefore, contribute towards reducing social disability of individuals with conditions that disrupt self-other processing such as schizophrenia.

PI_NAMEs: PARK, SOHEE  (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Afferent Neurons;Awareness;Behavior;Behavioral;Buffers;Chronic;Complex;Cues;Disabled Persons;effective intervention;Emotional;Environment;functional outcomes;Goals;Homeostasis;Impairment;Individual;interest;Interpersonal Relations;Link;Loneliness;Long term disability;Measures;Mental disorders;Methodology;Methods;multisensory;National Institute of Mental Health;neural;neural correlate;Neurocognitive;neuroimaging;neurophysiology;neuropsychiatry;nonhuman primate;novel;Participant;Pattern;Personal Space;phenomenological models;Prevalence;Process;Psychoses;Psychotic Disorders;Reaction Time;Regulation;Research Domain Criteria;Rest;Role;Schizophrenia;self-disturbance;sensory integration;social;Social Behavior;social deficits;Social disability;social factors;Social Functioning;Social Interaction;Social isolation;Specific qualifier value;Tactile;Technology;Testing;tool;virtual reality;virtual reality environment

PROJECT_TITLE: Spatial Self Boundary, Interpersonal Distance and Social Impairments in Schizophrenia


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Precision Medicine;Urologic Diseases

PHR: PROJECT 2 – NARRATIVE While the incidence of bladder cancer (BC) in men is nearly 4 times greater than in women men, women present with more advanced BC at diagnosis and have worse outcomes after treatment. Interestingly, in other cancer types, loss of the Y chromosome (LOY) is associated with increased risk of death in men, suggesting that the Y chromosome suppresses tumor aggressiveness yet the roles of Y in development, growth, progression, and therapy response remains to be determined, in any cancer type. Here we build upon our discovery that BC with LOY is more aggressive in animal models and is associated with worse prognosis in BC patients, to test the hypothesis that this is because LOY allows tumors to evade the immune system, which will provide the knowledge to develop novel and more effective precision therapies against this aggressive form of the disease.

PI_NAMEs: THEODORESCU, DAN  (contact)

PROJECT_TERMS: Address;Aftercare;Aggressive behavior;Alanine;Aminopeptidase;Animal Model;anti-PD-1;anti-PD1 therapy;Antibodies;Automobile Driving;autosome;B-Lymphocytes;Biological;Bladder;Bladder Neoplasm;cancer cell;Cancer Patient;cancer risk;cancer type;Catalogs;CD8-Positive T-Lymphocytes;Cell Line;Cell model;Cells;Cessation of life;chemical carcinogen;Chromatin;chromosome Y loss;Chromosomes;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Data;Data Set;Development;Diagnosis;Diagnostic;differential expression;Disease;druggable target;effective intervention;exhaust;Exposure to;Functional disorder;functional genomics;Gene Deletion;Gene Expression Profile;Gene Expression Profiling;Gene Structure;Genes;genetic signature;Growth;histone demethylase;Immune;immune cell infiltrate;immune checkpoint blockade;Immune Evasion;Immune response;Immune system;Immunity;Immunocompetent;Immunophenotyping;in vivo;Incidence;inhibitor;intravesical;Knockout Mice;Knowledge;Libraries;loss of function;Macrophage;male;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;men;Molecular;mortality risk;mosaic analysis;Mus;Mutagenesis;mutant;Myelogenous;Myeloid Cells;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;next generation sequencing;Nitrosamines;Normal Cell;novel;Operative Surgical Procedures;Outcome;overexpression;paralogous gene;patient prognosis;patient stratification;Patient-Focused Outcomes;Patients;pharmacologic;Phenotype;Precision therapeutics;Process;Prognosis;prognostic;prognostic indicator;programmed cell death protein 1;Proteins;Proteomics;recombinase;Risk;Role;sex;Smoking;T-Lymphocyte;Technology;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Intervention;Tobacco;transcriptome sequencing;Translating;treatment response;tumor;tumor growth;tumor progression;Tumor-associated macrophages;tumor-immune system interactions;tumorigenesis;Urothelial Cell;Urothelium;Wild Type Mouse;Woman;X Chromosome;Y Chromosome

PROJECT_TITLE: The Role of the Y Chromosome in Bladder Tumor Development, Growth And Progression


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: DING, XINXIN  (contact)

PROJECT_TERMS: Address;Area;arid land;Aridity;Arizona;Award;base;Budgets;career;Center for Translational Science Activities;climate change;Collaborations;college;community collaboration;community engagement;Core Facility;Data;Decision Making;design;Direct Costs;Disease;Ensure;Environmental Health;environmental justice;Equilibrium;Extramural Activities;Faculty;Feedback;Fees;Focus Groups;Fostering;Funding;Funding Opportunities;Goals;Grant;health science research;Incentives;Individual;innovation;Institution;Investments;Latinx;Measures;member;Mentors;National Institute of Environmental Health Sciences;Native Americans;Outcome;Persons;Pilot Projects;Population;Preparation;Process;Productivity;programs;Publications;recruit;Research;Research Design;Research Personnel;Resources;Risk;Rural Community;Secure;Shapes;Source;Strategic vision;Structural Racism;success;Technology;translational study;Universities;Vision;Work

PROJECT_TITLE: Pilot Project Program


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Dissemination and Implementation Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

ORG_CITY: BOSTON

ORG_NAME: UNIVERSITY OF MASSACHUSETTS BOSTON

ORG_STATE: MA

PHR: Project Narrative Despite strong consensus that early, specialized intervention for children with Autism Spectrum Disorder (ASD) can have a dramatic impact on outcomes, the public health system’s capacity to provide such services is severely challenged by the rapid rise in ASD prevalence. The goal of this research is to increase timely and equitable access to ASD-specialized early intervention during the critical first three years of life by capitalizing on the existing infrastructure of the Part C Early Intervention (EI) system, which is publicly funded and available in all U.S. States. This project will train EI providers to use an evidence-based, inexpensive, parent-mediated intervention that can improve child and family outcomes as well as mitigate the substantial economic costs associated with ASD.

PI_NAMEs: CARTER, ALICE S. (contact)

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: acceptability and feasibility;Address;Aftercare;Age;Area;autism spectrum disorder;autism symptoms;autistic children;Behavior;Behavior Therapy;Birth;Characteristics;Child;Child Language;Child Rearing;clinically relevant;Code;Consensus;Consensus Development;Consultations;Data;data management;Development;Developmental Delay Disorders;Developmental Disabilities;dosage;Early Intervention;economic cost;Educational process of instructing;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation design;effectiveness/implementation hybrid;Equity;evidence base;Evidence based intervention;Family;Family member;follow-up;Funding;Future;Goals;Health system;Heterogeneity;Home;hybrid type 1 design;Hybrids;implementation determinants;implementation evaluation;improved;improved outcome;Individuals with Disabilities Education Act;Infrastructure;innovation;Intervention;intervention program;Interview;joint attention;Language;Language Development;language outcome;Lead;Learning;Life;Measures;Mediating;member;Methods;Modification;Motor;multi-site trial;National Institute of Mental Health;Outcome;Parents;Patient Self-Report;Personal Satisfaction;Play;Population;Prevalence;Procedures;Protocols documentation;Provider;provider intervention;Public Health;quality assurance;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Reporting;Research;Role;Sample Size;Sampling;Self Efficacy;service delivery;service intervention;Services;Site;social communication;Source;Stress;System;Technology Assessment;Testing;Training;treatment as usual;treatment effect;Variant

PROJECT_TITLE: 4/4: Improving the Part C Early Intervention Service Delivery System for Children with ASD: A Randomized Clinical Trial


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Geographic atrophy (GA) is an advanced form of nonexudative or dry AMD that is characterized by loss of retinal pigment epithelial cells (RPE) and attenuation of choriocapillaris (CC); there is currently no therapy for GA. Our studies in the past grant period document the proinflammatory nature of the GA choroid with activation of macrophages and mast cells and that the mast cell activation alone is sufficient to create a GA-like phenotype in rat. The proposed studies focus on C-reactive protein (CRP), one of the proinflammatory molecules in GA choroid, and how CRP affects mast cells, choroidal macrophages, and retinal pigment epithelial (RPE) cells and CC endothelial cells, two cells that die GA.

PI_NAMEs: EDWARDS, MALIA MICHELLE (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Acute-Phase Proteins;Advanced Glycosylation End Products;Affect;Age related macular degeneration;Aging;Atrophic;attenuation;Binding Proteins;Binding Sites;Biological Assay;Bruch's basal membrane structure;C-reactive protein;Cathepsin G;Cell Count;Cell Death;Cell Degranulation;cell motility;Cell Physiology;Cells;Cessation of life;chemokine;Choroid;Chronic;Chymase;Complement 3a;Complement 5a;Complex;cytokine;Cytoplasmic Granules;Disease;Dryness;Effector Cell;Endothelial Cells;Enzymes;Epithelial Cells;Epithelium;Event;Exhibits;exosome;extracellular vesicles;Exudative age-related macular degeneration;Functional disorder;geographic atrophy;Grant;granule cell;Histamine;Human;Immune;In Vitro;in vivo;Inflammaging;Inflammation;Inflammatory;inhibitory surface receptor;Innate Immune System;intercellular communication;loss of function;Macrophage;Macrophage Activation;mast cell;Mesenchyme;migration;Modeling;Natural Immunity;Nature;Nonexudative age-related macular degeneration;novel therapeutics;Pathologic;Pathology;pharmacologic;Phenotype;Physiological;Pilot Projects;Play;prevent;Proteins;Publishing;Rattus;receptor;Reporting;Retina;Retinal Degeneration;Risk Factors;RNA;Role;Snake Venoms;Stimulus;Structure of retinal pigment epithelium;Testing;therapeutic target;Thinness;Tissues;Tryptase;Vision

PROJECT_TITLE: Inflammatory cells of choroid: a therapeutic target in AMD

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


NIH_SPENDING_CATS: American Indian or Alaska Native;Emergency Care;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research

PHR: Component Project Summary Not Required

PI_NAMEs: OLDFIELD, KENNETH  (contact)

PROJECT_TERMS: Air;Alabama;Alaska;Area;Back;Budgets;Chemicals;college;Communities;Confined Spaces;Country;Educational Status;Emergency Medical Technicians;Emergency response;emergency service responder;Emergency Situation;Employee;Environment;Equipment;Exercise;Fire - disasters;fire fighter;first responder;Fishes;Florida;Funding;Goals;Grant;hazardous materials disaster;Hazardous Substances;Hazardous Waste;Home;Hour;Human Resources;Industrialization;innovation;instructor;Law Enforcement;Learning;Louisiana;member;Mississippi;Modeling;National Institute of Environmental Health Sciences;Native American community;Native American Tribe;Native Americans;North Carolina;operation;Paramedical Personnel;peer;Persons;Police;Population;portability;prevent;programs;Recording of previous events;remediation;remote location;Resources;response;Safety;Sampling;Site;Societies;South Carolina;Southeastern United States;System;Target Populations;Tennessee;Time;Training;Training Programs;training project;Transportation;tribal lands;tribal member;Tribes;Work;Workplace

PROJECT_TITLE: AFC-HWWT


NIH_SPENDING_CATS: American Indian or Alaska Native;Climate-Related Exposures and Conditions;Emergency Care;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research

PROJECT_TERMS: active shooter;Alabama;Alaska;Awareness;Caring;college;Communities;Country;Devices;Disasters;Educational process of instructing;Emergency Medical Technicians;Employee;Event;Fire - disasters;fire fighter;first responder;Florida;Funding;Goals;hazard;hazardous materials disaster;Hazardous Substances;Hemorrhage;Hour;Human Resources;instructor;Law Enforcement;Laws;Life;Louisiana;man;mass casualty;Measures;Medical;member;Mississippi;Modeling;National Institute of Environmental Health Sciences;Native American Tribe;Native Americans;North Carolina;operation;Paramedical Personnel;peer;perpetrators;Police;Population;prevent;programs;Readiness;Recording of previous events;Resources;response;Safety;South Carolina;Southeastern United States;Target Populations;Tennessee;Training;Training Programs;Triage;tribal community;tribal member;Tribes;U-Series Cooperative Agreements;Violence;Work;Workplace

PROJECT_TITLE: AFC-HDPTP


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: DNA methylation plays a critical role in hematopoiesis, the process leading to the production of functionally specialized blood cells and is frequently deregulated in blood cancers such as myelodysplastic syndromes; however, treatments currently available to correct abnormal DNA methylation are highly toxic and non-specific, because the molecular players controlling DNA methylation establishment during hematopoiesis are largely unknown. This proposal is relevant to Public Health because it will identify key molecular switches of DNA methylation involved in normal hematopoiesis to develop in the future a targeted and non-toxic strategy to correct abnormal DNA methylation in disease states. This highly innovative approach will be instrumental in providing the long-awaited targeted therapeutic agents for the treatment of myelodysplastic syndromes, or other disease triggered by aberrant DNA methylation.

PI_NAMEs: DI RUSCIO, ANNALISA  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Aberrant DNA Methylation;Autoimmune Diseases;Automobile Driving;Binding;Biological;Biological Assay;Blood Cells;Bone Marrow;candidate selection;CCAAT-Enhancer-Binding Protein-alpha;Cell Cycle;cell type;Cells;clinical application;Code;Data;demethylation;Development;Disease;DNA Methylation;DNA Methylation Regulation;DNA Modification Methylases;Down-Regulation;Dysmyelopoietic Syndromes;Epigenetic Process;evidence base;Foundations;Future;gain of function;gene synthesis;Generations;Genes;genome-wide;genomic locus;Goals;granulocyte;Guide RNA;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;hematopoietic differentiation;hematopoietic gene;Hematopoietic Neoplasms;Hematopoietic System;Human;In Vitro;Individual;innovation;Knowledge;loss of function;Malignant Neoplasms;Maps;Mediating;Methods;Methylation;methylation pattern;Molecular;Mononuclear;Muscle;Myelogenous;Nervous System Disorder;Neurons;Oligonucleotides;Outcome;Pathologic;Play;prevent;Process;Production;programs;Public Health;Research;RNA;Role;S phase;Sampling;Specificity;targeted treatment;Testing;Time;Tissues;tool;Toxic effect;Transcript;Transcriptional Regulation;Variant;whole genome

PROJECT_TITLE: Understanding the role of cell-cycle specific RNAs in hematopoiesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Estrogen;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Urologic Diseases;Women's Health Research

PHR: PROJECT 3 – PROJECT NARRATIVE Bladder cancer is a highly sex-biased disease that disproportionately affects males, but the underlying mechanism remains largely undefined. In this Project, we aim to uncover the overlooked epigenetic basis of observed sex differences. We expect to identify sex-biased epigenetic pathways that can be used to develop future sex-specific bladder cancer screening and treatment to ultimately mitigate existing sex disparities.

PROJECT_TERMS: 3-Dimensional;Affect;Androgen Receptor;Androgens;Automobile Driving;Biological;Bladder;Bladder Neoplasm;Bladder Urothelial Cell;Breast Cancer Cell;cancer cell;cancer initiation;Cancer Patient;cancer risk;CCL8 gene;chemokine;chromosome Y loss;Chromosomes;Clinical;conditional knockout;Data;Development;Differentiation and Growth;Disease;Disparity;Environmental Risk Factor;Epigenetic Process;epigenome;Estrogen Receptors;Estrogens;Etiology;Exhibits;Female;Four Core Genotypes;Future;Gene Expression Regulation;Gene Proteins;Genes;Genetic Transcription;genome-wide analysis;Geography;Gonadal Steroid Hormones;Growth;hazard;Histones;Human;Immune;Immunity;immunoregulation;improved;in vivo;Incidence;Interferon alpha;knock-down;Knockout Mice;Knowledge;Link;Lysine;male;Malignant neoplasm of urinary bladder;Malignant Neoplasms;men;Monocyte Chemoattractant Proteins;mortality;Mus;muscle invasive bladder cancer;mutant;Natural regeneration;neutralizing antibody;non-muscle invasive bladder cancer;novel therapeutics;Odds Ratio;Organoids;Outcome;paralogous gene;Pathway interactions;Patients;Play;prostate cancer cell;Publishing;Regulation;Reporting;Research;response;Risk Factors;Role;Screening for cancer;sex;sex as a biological variable;Sex Bias;Sex Chromosomes;Sex Differences;sex disparity;sexual dimorphism;Shapes;Smoking;socioeconomics;Somatic Mutation;stem;Testing;Tissues;TP53 gene;Translating;Transplantation;tumor progression;Tumor Suppression;Tumor Suppressor Proteins;tumor-immune system interactions;tumorigenesis;tumorigenic;Urinary tract infection;Urothelium;Woman;women's outcomes;X Chromosome;X Inactivation

PROJECT_TITLE: The Kdm6a-dependent Sex Epigenome in Bladder Tumor Suppression


ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Harnessing a patient’s immune system to attack melanoma is remarkably successful. In one promising approach T cells are harvested directly from the patient’s tumor, expanded to very high numbers in the laboratory where they can be rejuvenated, and returned to the patient to fight their cancer. As this is only effective in approximately half of patients with advanced disease, here we develop a novel, safe and efficient method to further boost these tumor-reactive T cells by mRNA reprogramming.

PI_NAMEs: HURWITZ, MICHAEL E;KATZ, SAMUEL G (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Acclimatization;Address;Adoptive Immunotherapy;advanced disease;Antitumor Response;Apoptotic;Back;Cell Differentiation process;cell mediated immune response;Cell Reprogramming;Cell Therapy;Cells;Clinical;Clinical Trials;cytokine;Cytolysis;Data;design;Dose;effector T cell;efficacy evaluation;Electroporation;Environment;experimental study;fighting;Fishes;Fluorescent in Situ Hybridization;Frequencies;Future;gene therapy;Generations;Genes;Goals;Harvest;humanized mouse;Image;Immune checkpoint inhibitor;Immune system;Immunologic Factors;Immunotherapy;improved;In complete remission;In Vitro;Individual;Infrastructure;Infusion procedures;Insertional Mutagenesis;instrument;Interleukin-2;Knowledge;Laboratories;Lesion;life span;Ligands;long term memory;Lymphocyte;Lymphocyte Activation;lymphocyte product;Malignant - descriptor;Malignant Neoplasms;manufacture;Mediating;Melanoma;Melanoma patient;Melanoma Tumor;Memory;Messenger RNA;Metastatic Melanoma;Methods;mouse model;mRNA Expression;multidisciplinary;neoplastic cell;novel;objective response rate;Outcome;OX40;Pathway interactions;patient derived xenograft model;patient population;Patients;Phenotype;Population;Population Heterogeneity;Positioning Attribute;pre-clinical;Production;programs;Property;Proteins;Protocols documentation;Rejuvenation;Research;response;RNA;Safety;Sampling;single cell analysis;single-cell RNA sequencing;success;System;T cell receptor repertoire sequencing;T cell therapy;T-Cell Receptor;T-Lymphocyte;Therapy Clinical Trials;Time;TNFSF4 gene;transcriptomics;Transfection;Treatment Efficacy;tumor;Tumor Antigens;Tumor Expansion;tumor growth;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Variant;Work

PROJECT_TITLE: Enhancing Melanoma TIL Efficacy with Multifactor mRNA-Mediated T Cell Reprogramming


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Disability Research;Physical Activity;Physical Rehabilitation;Rehabilitation

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE  The ENLIGHTEN PAD Trial will collect preliminary data to test whether daily 670 nm light treatment of the lower extremities immediately before home-based walking exercise sessions increases walking exercise intensity and improves six-minute walk at 4-month follow-up, compared to sham light, in people disabled by lower extremity peripheral artery disease.

PI_NAMEs: MCDERMOTT, MARY MCGRAE (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Accelerometer;actigraphy;Acute;Age;arterial spin labeling;Biological;Biopsy;Blood capillaries;Cell Nucleus;Chronic;Citrate (si)-Synthase;Clinical Trials;comparison control;Control Groups;cytochrome c oxidase;Data;density;design;disability;Disabled Persons;Dose;Exercise;exercise adherence;exercise intensity;exercise intervention;Exercise Therapy;follow-up;functional improvement;Gait abnormality;Gastrocnemius Muscle;Health;Home;Impairment;improved;improved mobility;Intervention;Ischemia;Isolated limb perfusion;Leg;Light;light effects;Light Exercise;Lower Extremity;Magnetic Resonance Imaging;Measures;meter;Mitochondria;Muscle;Muscle Fibers;Muscle satellite cell;Nitric Oxide;Nitrites;Older Population;Outcome;Participant;Pathology;Pathway interactions;Perfusion;Peripheral arterial disease;Persons;phase II trial;Phototherapy;Plasma;Property;Quality of life;Questionnaires;Randomized;randomized trial;Reporting;Signaling Molecule;Skeletal Muscle;Source;Symptoms;Testing;Therapeutic;Walking

PROJECT_TITLE: ENhancing exercise with LIGHT to improve functioning in PAD: the ENLIGHTEN PAD Trial

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE BRAIN pioneers are people who take on significant risk as participants in first-in-human or early neurotechnology studies for the sake of helping to further science. Their willingness to try invasive and non- medically necessary devices, their investments of significant time and energy, and their close relationships with study teams, typically built over 3-5 years of intensive experiments, make them relatively unique as research participants, yet relatively little neuroethical attention has been focused on the structures of support, from researchers and family members, that enable BRAIN pioneers to successfully participate in neural device trials. This study will identify forms of family and researcher support that are integral to the well-being of BRAIN pioneers, and produce recommendations for best practices that will help shape future trials and contribute to a smooth translation into the clinical sphere.

PI_NAMEs: GOERING, SARA  (contact);KLEIN, ERAN

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TITLE: Caring for BRAIN pioneers: Understanding and enhancing family and researcher support in neural device trials


NIH_SPENDING_CATS: Cancer;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases;Women's Health Research

PHR: ADMINISTRATIVE CORE – NARRATIVE The Administrative Core (Admin Core) will provide critical services to support the overall integration and management of this P01 Program Project Grant that is distributed among two academic research institutions. The Admin Core will oversee and manage the progression of research milestones across the three Projects and two shared resource Cores. The Admin Core will catalyze scientific collaborations among the research team members; facilitate the sharing, integration and dissemination of knowledge and data; and ensure accountability and regulatory compliance with all institutional, state, and federal requirements and laws.

PROJECT_TERMS: Accountability;Advisory Committees;Biological Process;Chromosomes;Collaborations;Communication;Data;data integrity;data management;data sharing;Direct Expenditure;Ensure;ethnic minority;Extramural Activities;Female;Gender;Goals;Grant;Immunity;Incidence;Individual;Institution;Knowledge;Laws;Leadership;male;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Medicine;member;men;Minority Health Research;Molecular;Monitor;mortality;Odds Ratio;Persons;Policies;Program Research Project Grants;programs;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk Factors;Science;Secure;Services;sex;Sex Bias;Sex Differences;sexual dimorphism;symposium;synergism;Tissues;United States National Institutes of Health;Update;virtual;web site;Woman;Work

PROJECT_TITLE: Administration Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Women's Health Research

ORG_CITY: STANFORD

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The comprehensive Women’s Reproductive Health Research at Stanford offers OB/GYN junior clinician- investigators an individually tailored program of didactic research methods and mentored career development to bridge the transition to academic independence. The primary goal is to develop diverse, highly trained, creative and productive independent investigators in reproductive science to address the increasing opportunities in this field. Having this program embedded in Stanford’s rich culture of innovation and collaboration provides an exceptional environment to empower the next generation of independent investigators who will advance reproductive health for all.

PI_NAMEs: SUBAK, LESLEE L (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, STEVEN

PROJECT_TERMS: Address;Advisory Committees;Area;Basic Science;Biology;bridge program;career;career development;clinical care;Clinical Research;Collaborations;Committee Members;Communities;Competence;didactic education;Discipline;Educational Curriculum;Environment;Epidemiology;experience;Faculty;faculty mentor;Future Generations;Gender;gender equity;global health;Growth;Gynecologic;Gynecologic Oncology;hands on research;Health;Immersion;improved;Infrastructure;innovation;innovative technologies;Interdisciplinary Study;Leadership;Lesbian Gay Bisexual Transgender Queer;life span;Maternal and Child Health;medical schools;Medicine;Mentors;Mission;multidisciplinary;Outcome;Perinatal;Physicians;Precision Health;precision medicine;Productivity;Program Development;programs;Qualifying;recruit;reproductive;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Schools;Scientist;skill acquisition;skills;Solid;stem cell biology;Structure;System;Time;Training;Training Programs;Translational Research;women's reproductive health

PROJECT_TITLE: Stanford Women's Reproductive Health Research Career Development Program


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Urologic Diseases;Women's Health Research

PHR: CORE 1, SYSTEMS PATHOLOGY – NARRATIVE The overarching goal of the Systems Pathology Core is to process and analyze high quality biospecimens, including murine and human clinical specimens, to address Program aims. The core will act as a high-quality biorepository and provide (1) multiparameter histology and pathology services and (2) provide flow cytometry and single cell analysis services. The Systems Pathology Core will work closely with the Administrative Core and the Data Science Core, which will provide robust data management and analysis of the data acquired.

PI_NAMEs: PARWANI, ANIL V (contact)

PROJECT_TERMS: Address;ATAC-seq;biobank;cancer cell;cancer risk;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chromosomes;Clinical;Collection;Comparative Pathology;Consultations;Cooperative Human Tissue Network;Cytometry;Data;Data Analyses;data integrity;data management;Data Science Core;Detection;Diagnostic;digital imaging;Ensure;Epigenetic Process;epigenomics;Female;Flow Cytometry;Genomics;Goals;Gonadal Steroid Hormones;Histology;Human;Immune;Immunity;Immunofluorescence Immunologic;Immunohistochemistry;Immunologic Monitoring;Incidence;indexing;Institution;male;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Manuscripts;Maps;Medical center;method development;Molecular Analysis;Mus;neoplastic cell;Ohio;Outcome;Pathologic;Pathologist;Pathology;pathology imaging;Process;programs;Research;Research Personnel;Resource Sharing;Resources;Risk Factors;Role;Services;sex;Sex Bias;Sex Chromosomes;Sex Differences;sex disparity;Signal Induction;single cell analysis;single-cell RNA sequencing;Site;Smoking;Sorting;Specimen;System;Techniques;therapy resistant;Translational Research;treatment response;tumor microenvironment;tumor progression;Universities;Work;Writing

PROJECT_TITLE: Core 1: Systems Pathology Core


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE Environmental cues associated with alcohol can promote problematic drinking and relapse even after treatment. We recently used a novel behavioral paradigm to successfully prevent relapse in rats with moderate-level exposure to alcohol. In the current proposal, we will test the generalizability of our procedure using rats with a history of alcohol dependence and probe the neural substrates for successful prevention of relapse.

PI_NAMEs: LEE, HONGJOO JOANNE (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Aftercare;Alcohol abuse;alcohol abuse therapy;alcohol availability;Alcohol consumption;alcohol cue;Alcohol dependence;alcohol exposure;alcohol measurement;alcohol rehabilitation;alcohol relapse;alcohol response;alcohol seeking behavior;alcohol use disorder;Alcohols;Amygdaloid structure;Animal Model;Animals;Association Learning;Attenuated;attenuation;Behavior;Behavioral;Behavioral Model;Behavioral Paradigm;Biological Factors;Cocaine;Conditioned Reflex;Conditioned Stimulus;conditioning;Consumption;Cues;Dependence;drinking;Effectiveness;Electrophysiology (science);Ensure;Ethanol;Exposure to;Extinction;Female;Fluorescent in Situ Hybridization;Fright;Heroin;Heroin Dependence;Human;human model;Immunohistochemistry;improved;in vivo;Individual;innovation;interest;Light;Link;male;Maps;memory retrieval;Messenger RNA;Methods;Modeling;Modification;Nature;neural;neural network;neuromechanism;novel;Phase;Predisposition;Prefrontal Cortex;Procedures;Process;Protocols documentation;psychologic;Rattus;Recording of previous events;Recovery;Relapse;relapse prevention;response;Retrieval;Role;sex;social;Stimulus;Testing;Time;vapor;Withdrawal;Work

PROJECT_TITLE: Reducing alcohol-seeking behavior in a rat model of alcohol dependence

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Mitral regurgitation (MR), the most frequent form of valvular heart diseases, results in depressed left ventricular (LV) systolic function, which is not responsive to medical management. In the current proposal, we developed the first mouse model of severe MR, which we will use to unravel the molecular mechanisms that mediate LV dysfunction secondary to severe MR.

PI_NAMEs: DRAKOS, STAVROS GEORGE (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Address;Adult;Age;Animals;ataxia telangiectasia mutated protein;Cardiac;Cardiac Myocytes;cell growth;Cell Nucleus;Cell Polarity;Cell Shape;Chronic;Compensation;Data;Depressed mood;Development;Dilatation - action;directional cell;Disease;DNA;DNA Damage;Echocardiography;Europe;Frequencies;Functional disorder;Genes;Genetic;Genetic Models;Goals;Growth;Heart;Heart failure;Heart Valve Diseases;hemodynamics;Human;Hypertrophy;Incidence;Intercalated disc;Iridectomy;Knockout Mice;Left;Left Ventricular Dysfunction;Left Ventricular Remodeling;Length;Link;Mediating;Mediator;Medical;Messenger RNA;Mitral Valve;Mitral Valve Insufficiency;Modeling;Molecular;Morphology;mouse model;mRNA Expression;mRNA Translation;Mus;Myocardial;Myocardial dysfunction;Myocardium;Natural History;novel therapeutic intervention;Operative Surgical Procedures;oxidative DNA damage;Pathway interactions;Patients;Pattern;Phase;Polyribosomes;Population;postnatal development;pressure;prevent;Protein Biosynthesis;Public Health;Publishing;Rattus;Regulation;Research;response;Role;Secondary to;Shapes;Stimulus;targeted treatment;Testing;Thick;tool;upstream kinase;Ventricular

PROJECT_TITLE: Mechanism of Eccentric Cardiomyocyte Hypertrophy Secondary to Mitral Regurgitation

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Chronic Pain;Digestive Diseases;Microbiome;Neurosciences;Pain Research;Women's Health Research

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Abdominal pain is a common symptom of gastrointestinal disorders and there are few effective treatments. This proposal will test how specific hormones generated by bacteria that normally live in the bowel signal to gut nerves to influence pain sensation, and whether altering this signaling could be a new strategy for treating abdominal pain.

PI_NAMEs: RAO, MEENAKSHI  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Abdominal Pain;Address;Affect;Afferent Neurons;Androgen Receptor;Androgens;Antibiotics;antinociception;Bacteria;Beta-glucuronidase;Bile fluid;cellular targeting;Central Nervous System;Chemistry;chronic abdominal pain;chronic pain;Colon;Colorectal;commensal microbes;common symptom;Communication;Data;Diagnosis;Digestive System Disorders;Disease;dysbiosis;effective therapy;enzyme activity;Enzyme Inhibitor Drugs;Enzymes;Esthesia;Excretory function;Exhibits;experience;Female;Gastrointestinal Diseases;Genetic;Germ-Free;Glucuronides;Gnotobiotic;Goals;Gonadal Steroid Hormones;gut microbes;gut microbiota;gut-brain axis;healing;High Prevalence;Homeostasis;Hormones;host-microbe interactions;Human;Hypersensitivity;In Vitro;in vivo;Individual;Inflammatory;Inflammatory Bowel Diseases;inflammatory pain;inhibitor;innovation;Intestines;Irritable Bowel Syndrome;Link;Liver;male;Mediating;Mediator;men;Microbe;microbial;microbiota;Modeling;Molecular;mouse model;Mucous Membrane;Mus;Natural regeneration;Nerve;neuronal excitability;Neurosecretory Systems;Nociceptors;normal microbiota;novel;Pain;Pain Disorder;pain sensation;pain signal;Pathway interactions;Patients;Peripheral;Population;Probiotics;programs;protective effect;Puberty;Research;Research Personnel;response;Rodent;Role;Sensory Thresholds;Severities;sex;Sex Differences;Signal Transduction;small molecule;Spinal;Stanolone;steroid hormone;Steroids;Stimulus;Symptoms;Testing;Testosterone;therapeutic target;Visceral;Visceral Afferent Neuron;Visceral Afferents;Visceral pain;Woman;Women's prevalence;Work

PROJECT_TITLE: Microbial reactivation of sex steroids and visceral pain

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Bioengineering;Cancer;Data Science;Networking and Information Technology R&D (NITRD);Urologic Diseases

PHR: CORE 2, DATA SCIENCE – NARRATIVE The Data Science Core serves as a comprehensive, multi-disciplinary resource of expertise in biostatistics and bioinformatics to assist investigators from all projects to design their experiments, manage and maintain the large volume of data, make inference regarding the stated aims, and formulate new hypotheses based on discoveries arising from exploration and visualization of the integrated data.

PROJECT_TERMS: Achievement;Address;analysis pipeline;Animal Experiments;anti-cancer research;Basic Science;Bioinformatics;Biological;Biometry;central database;Chromosomes;Collaborations;Computational Technique;Computer Analysis;Computer software;computerized data processing;computerized tools;Computers;Data;data access;Data Analyses;data analysis pipeline;data harmonization;data integration;data management;data quality;Data Science;Data Science Core;Data Storage and Retrieval;Database Management Systems;Databases;design;Development;Ensure;Experimental Designs;experimental study;Goals;Health Insurance Portability and Accountability Act;Immunity;Institutional Review Boards;Investigation;laboratory experiment;Malignant neoplasm of urinary bladder;Manuscripts;mathematical model;member;Methodology;Mining;multidisciplinary;Multiomic Data;Nature;Outcome;Participant;Pathology;Patients;preservation;Procedures;Program Research Project Grants;programs;Randomized;Regulation;relational database;Research;Research Methodology;Research Personnel;Research Project Grants;research study;Research Support;Resources;Retrieval;Role;Sample Size;sex;Specimen;Standardization;Structure;System;Testing;Translating;Translational Research;Visualization;Writing

PROJECT_TITLE: Core 2: Data Science Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE In this proposal, we aim to develop a new class of therapeutic candidates for AD based on soluble amyloid precursor alpha (sAPPα)-enhancing analogs of tropisetron (F03) that we have in-hand, as well as new optimized analogs for their ability to decrease the phospho-tau/total-tau (p-tau/t-tau) ratio in human SH-SY5Y neuroblastoma cells, primary neurons from 3xTg Alzheimer's disease (AD) model mice, and human iPSC- derived neurons; prioritized compounds would undergo ADME and oral brain permeability analyses to select lead candidates for acute and chronic efficacy studies in 3xTg-AD and ApoE4-5XFAD mice. The multifunctional properties of 5-HT3 serotonin receptors antagonism, α7 nicotinic acetylcholine receptor agonism, and binding to the extracellular domain of APP along with kinase inactivation would be evaluated. The key goal is to identify advanced lead candidates with oral brain bioavailability, sAPPα enhancement and p-tau/t-tau lowering that affect both amyloid and tau pathology and improve cognition for treatment of AD and tauopathies.

PI_NAMEs: JOHN, VARGHESE  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: 3xTg-AD mouse;Acute;ADME Study;Aducanumab;Affect;Affinity;aged;Agonist;alpha-bungarotoxin receptor;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease therapy;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;analog;antagonist;Antibodies;apolipoprotein E-4;Artificial Membranes;Behavioral;Binding;Binding Proteins;Biochemical;Biological;biological adaptation to stress;Biological Assay;Biological Availability;Brain;candidate selection;Cause of Death;Cell Membrane Permeability;Cells;Chemistry;Chronic;Cognition;Cognitive;cognitive benefits;combinatorial;Corticotropin-Releasing Hormone;Country;Data;density;design;Development;Dose;Drug Kinetics;efficacy study;Enhancers;Evaluation;Extracellular Domain;FDA approved;glycogen synthase kinase 3 beta;Goals;Hand;Hippocampus;Histopathology;Human;hyperphosphorylated tau;Impaired cognition;improved;In Vitro;in vivo;in vivo evaluation;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Injections;J20 mouse;lead candidate;Ligands;Membrane;Memory;Microsomes;mouse model;Mus;Muscarinic M1 Receptor;Muscarinic M3 Receptor;Neurites;neuroblastoma cell;neurofibrillary tangle formation;Neurofibrillary Tangles;Neurons;neuroprotection;new chemical entity;new therapeutic target;novel therapeutic intervention;novel therapeutics;Oral;Outcome;Pathology;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;phosphoproteomics;Phosphorylation Site;Phosphotransferases;Postoperative Nausea and Vomiting;presenilin-1;Property;receptor;receptor binding;Reporting;response;Running;Safety;screening;Serotonin;Serotonin Antagonists;serotonin receptor;Site;small molecule;Solubility;Structure-Activity Relationship;Synapses;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;therapeutic candidate;therapeutically effective;Tropisetron;Vertebral column

PROJECT_TITLE: Evaluating the p-Tau inhibition and neuroprotective effects of sAPPalpha using brain permeable small molecules

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


ADMINISTERING_IC: AI

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative. The proposed research will advance our understanding of how effective immune responses enable macrophages to kill M. tuberculosis. This work is relevant to public health because understanding how macrophages contribute to control M. tuberculosis infection will have significant implications for the development of novel immune based therapeutics and vaccines. Thus the proposed research will help contribute fundamental knowledge that will reduce the enormous burden that tuberculosis imposes on public health.

PI_NAMEs: STANLEY, SARAH A (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: aerobic glycolysis;Anti-Inflammatory Agents;antimicrobial;Bacteria;Bacterial Infections;bactericide;Biological Models;Carrier Proteins;CD4 Positive T Lymphocytes;Cell membrane;Cells;Cues;cytokine;Data;Development;Ensure;Equilibrium;experimental study;Feedback;Funding;Gene Expression;Genes;Goals;Growth;Hypoxia Inducible Factor;Immune;Immune response;Immunity;Immunotherapeutic agent;in vivo;Individual;Infection;Infection Control;Inflammation;Inflammatory Response;Interferon Type II;Interleukin-1 beta;Knowledge;Link;Macrophage;Macrophage Activation;Mediating;Membrane;Metabolic;Metabolic Pathway;Metabolism;microbicide;Mus;Mycobacterium tuberculosis;Myeloid Cells;Nitric Oxide;NOS2A gene;novel;novel therapeutics;novel vaccines;pathogen;pathogenic bacteria;Patients;Persons;Predisposition;Production;programs;Proteins;Public Health;Regulation;Reporting;Research;response;Role;Series;Signal Transduction;solute;System;Testing;therapeutic development;transcription factor;Tuberculosis;Vaccines;Work

PROJECT_TITLE: Metabolic regulation of macrophage function during M. tuberculosis infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Mental Health;Neurosciences;Substance Misuse

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative Perturbations within the dopamine neurotransmitter system of the brain is broadly linked to neurological disorders, mental illness, and addiction. The way distinct dopamine systems are regulated at the circuit, molecular, and pharmacological level remains poorly resolved. We will use advanced genetic and pharmacological techniques to determine how dopamine subsystems within the ventral tegmental area are regulated that will provide important insights for therapeutics development.

PI_NAMEs: ZWEIFEL, LARRY S (contact)

PROGRAM_OFFICER_NAME: MCCLURE-BEGLEY, TRISTAN DAVID

PROJECT_TERMS: addiction;Address;Affective;Association Learning;Behavior;Behavioral;Brain;Calcium;Calcium Signaling;cell type;Cells;Cholecystokinin;Clustered Regularly Interspaced Short Palindromic Repeats;Corticotropin-Releasing Hormone Receptors;Coupled;Cre driver;Cues;Decision Making;differential expression;Disease susceptibility;Dopamine;dopamine system;dopaminergic neuron;Electrophysiology (science);Endowment;Foundations;Functional disorder;Genes;Genetic;genetic approach;Genetic Heterogeneity;genetic signature;Heterogeneity;in vivo;in vivo calcium imaging;insight;Ion Channel;Learning;Link;Literature;Mental disorders;mesolimbic system;Methods;Molecular;Molecular Genetics;motivated behavior;Motivation;Mus;Mutagenesis;Nervous System Disorder;Neurokinin B;Neuromedin K Receptor;neuronal excitability;Neurons;Neuropeptide Receptor;Neuropeptides;neuropsychiatric disorder;Neurotransmitters;novel strategies;Nuclear RNA;Nucleus Accumbens;optogenetics;Pathway interactions;pharmacologic;Pharmacology;Play;Population;Property;Psychological reinforcement;receptor;receptor function;Receptor Gene;Receptor Signaling;Regulation;response;Rewards;Role;segregation;Signal Pathway;Signal Transduction;Stimulus;Symptoms;System;Techniques;Therapeutic;therapeutic development;transcriptome sequencing;Uncertainty;Ventral Tegmental Area;Viral;Voltage-Gated Potassium Channel

PROJECT_TITLE: Isolation of brain reward circuits using peptidergic systems

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Project Narrative: An in depth understanding of the novel signaling molecules and pathways in platelets will help us understand how signaling pathways are regulated in other cells. Understanding these signaling cascades in platelets will help us evaluate and predict possible implications of the therapeutic agents that could interfere with these pathways.

PI_NAMEs: KUNAPULI, SATYA P. (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Age;Applications Grants;Atherosclerosis;Blood flow;Blood Platelets;Blood Vessels;Cells;Chronic Lymphocytic Leukemia;Diabetes Mellitus;Disease;Environment;Event;Focus Groups;Funding;Genetic;Goals;Hemostatic function;Inflammation;insight;kinase inhibitor;Lesion;lymphatic vessel;Malignant Neoplasms;Mediating;MicroRNAs;new therapeutic target;novel;Paper;Pathway interactions;Platelet Activation;platelet function;Play;Predisposition;Protein Kinase;Protein Tyrosine Kinase;Publishing;Reagent;receptor;receptor-mediated signaling;Regulation;Research;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Surface;System;TEC Protein Tyrosine Kinase;Therapeutic Agents;Thrombocytopenia;Thrombosis;thrombotic;tool;Tyrosine Phosphorylation;United States National Institutes of Health;Work

PROJECT_TITLE: Novel signaling molecules regulating platelet activation


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Neurosciences;Rehabilitation;Rural Health;Telehealth;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE The proposed research will examine the efficacy of a videoconference-delivered cognitive-behavioral therapy (CBT), Memory and Attention Adaptation Training (MAAT) vs. an attention control condition (supportive therapy; ST), in a large, multi-site, randomized controlled trial (RCT) to improve subjective and objective cognitive functioning in breast cancer survivors with chemotherapy-related cognitive dysfunction (CRCD). Another goal of the research is to use functional MRI (fMRI) to evaluate underlying changes in brain activation patterns that are believed to be associated with positive effects of MAAT. If successful, results of this work will: (1) produce an evidence-based treatment that can be immediately disseminated to cancer centers and other healthcare settings to treat CRCD and (2) help inform further treatment development through improved understanding of mechanisms that promote CRCD recovery.

PI_NAMEs: FERGUSON, ROBERT J;MCDONALD, BRENNA C;POSLUSZNY, DONNA M (contact)

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: active control;active control group;Address;Aftercare;Attention;attentional control;Behavioral;Brain;Brain Injuries;Brain region;Breast Cancer survivor;Breast Cancer survivorship;cancer care;Cancer Center;Cancer Survivor;Caring;chemotherapy;Clinical;Cognitive;cognitive change;cognitive enhancement;cognitive function;cognitive performance;Cognitive Therapy;cognitive training;Compensation;computerized;control trial;coping;Data;density;design;Development;disability;effective therapy;efficacy evaluation;emotion regulation;emotional adjustment;Evidence based treatment;experience;Failure;follow up assessment;follow-up;Fostering;Foundations;frontal lobe;Functional Magnetic Resonance Imaging;Goals;gray matter;handheld mobile device;health care settings;Health Services Accessibility;Impaired cognition;improved;Individual;Intervention;Life;Link;Malignant Breast Neoplasm;Memory;Methodology;mindfulness;mobile computing;Modification;Neurobehavioral Manifestations;Neurocognitive;neuroimaging;non-drug;Nonpharmacologic Therapy;Outcome;Outcome Measure;Participant;Patient Self-Report;Patients;Pattern;Performance;Personal Satisfaction;personalized intervention;Pharmaceutical Preparations;Physical activity;pill;Pilot Projects;Placebos;Population;primary outcome;Process;processing speed;public health priorities;Publishing;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Recovery;Rehabilitation therapy;Research;Risk;Ritalin;Rural;rural area;Sample Size;Secure;Self Management;Self Perception;Short-Term Memory;Site;Supportive care;Survivors;survivorship;Task Performances;Testing;therapy development;Time;Training;translational potential;Traumatic Brain Injury;Travel;videoconference;Videoconferencing;Visit;Waiting Lists;Work

PROJECT_TITLE: Mobile Device CBT for Chemotherapy-Related Cognitive Dysfunction: A Multi-Center Randomized Controlled Trial

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: RICHARDSON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: Project Narrative Lipids are major components of bacterial membranes and help bacteria cause infectious diseases. Yet, membrane lipids remain uncharacterized for many significant bacterial pathogens. We investigate the roles of newly discovered, highly positively charged lipids in bacterial pathogenesis.

PI_NAMEs: DORAN, KELLY S;GUAN, ZIQIANG ;PALMER, KELLI LEA (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Abbreviations;Address;Anabolism;antimicrobial;Bacteria;Biochemical;Blood - brain barrier anatomy;blood-brain barrier disruption;Brain;Cell surface;Cell Wall;Charge;Chemical Structure;Chemicals;Communicable Diseases;coping;Development;Diglycerides;Dissection;Endothelial Cells;Enterococcus;Enzymes;Family;Genes;Genetic;genetic approach;glucosyl diacylglycerol;Glycerol;Glycolipids;Gram-Positive Bacteria;guided inquiry;Human;Infant;Inflammation;Inflammatory;inorganic phosphate;Invaded;Knowledge;lipidomics;Lipids;lipoteichoic acid;Lysine;Machine Learning;Mediating;Membrane;Membrane Lipids;Meningitis;model organism;Molecular;Molecular Evolution;mouse model;Neonatal meningitis;Neurologic Effect;novel;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Penetration;Peptides;Phosphatidylglycerols;Physiological;Play;Property;Research;resistance factors;Role;Statistical Models;Streptococcus Group B;Stress;Structure;Substrate Specificity;Surface;Tight Junctions;Tissues;transcytosis;Vesicle;Virulence Factors

PROJECT_TITLE: Roles of novel cationic lipids in bacterial pathogenesis

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Hypertension;Nutrition;Prevention

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE This dietary intervention study will examine the effect of a prescribed, laboratory-prepared, home-delivered Dietary Approaches to Stop Hypertension (DASH) diet intervention on novel and clinically important markers of heart failure status in older adults. Given the high human and economic costs associated with heart failure complications among older adults, the clinical testing of a nutritional intervention represents a much needed, low-cost, and prudent strategy likely to improve heart failure outcomes. This project will contribute to fundamental knowledge to advance heart failure patient care.

PI_NAMEs: SATTLER, ELISABETH LILIAN PIA (contact)

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: Acute;Address;aging related;arterial stiffness;Biological Markers;Blood Pressure;Cardiac;cardiac cachexia;Cardiology;Clinical;Clinical Nutrition;Clinical Research;Clinical Sciences;Clinical Trials;Congestive Heart Failure;Consumption;cost;Cross-Over Studies;DASH diet;Data;design;Development;Devices;Diagnosis;Diastolic blood pressure;Diet;Dietary Intervention;dietary restriction;Diuretics;Early Intervention;economic cost;Edema;EFRAC;Electrolytes;Energy Intake;Environment;experience;feeding;Functional disorder;Gastrointestinal tract structure;Health Care Costs;Health Promotion;health related quality of life;healthcare burden;Heart failure;Heart Rate;hemodynamics;Home;hospital readmission;Hospitalization;Human;human old age (65+);Implant;implantable device;improved;Infrastructure;Intake;Intervention;Intervention Studies;Knowledge;Laboratories;Length;Malnutrition;micronutrient deficiency;Modality;Monitor;monitoring device;mortality;Natriuretic Peptides;novel;nutrition;Nutritional;Nutritional Support;older adult;older patient;Operative Surgical Procedures;Outcome;Oxidative Stress;Parents;Participant;Patient Care;patient oriented research;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;Physiological;Pilot Projects;preservation;Prevention;pro-brain natriuretic peptide (1-76);Prognosis;Prognostic Marker;programs;prospective test;Public Health;pulmonary arterial pressure;Quality of life;Randomized;Recommendation;Research;research clinical testing;Research Design;Research Project Grants;response;Safety;Shortness of Breath;Sodium;Symptoms;Target Populations;telemonitoring;Therapeutic;Translational Research;treatment as usual;trend;Ventricular Function;Visit;Weight Gain;Woman

PROJECT_TITLE: Effect of Dietary Approaches to Stop Hypertension (DASH) Diet on Heart Failure Status in Older Adults

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ORG_CITY: PROVIDENCE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE The proposed research will further our understanding of SLC13A5-associated citrate transporter disorder by establishing and characterizing Drosophila and mouse models for the disease. These studies will provide evidence supporting the complexity of SLC13A5 disease mechanisms as well as designing potential therapies for this disorder. Using our novel models, our multidisciplinary approach will characterize phenotype-genotype relationships and molecular mechanisms underlying SLC13A5 disease, and use the power of Drosophila genetics to design new therapeutic strategies.

PI_NAMEs: HELFAND, STEPHEN L;LIU, JUDY SHIH-HWA (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Affect;Alleles;Animal Diseases;Animal Model;Astrocytes;autosome;Behavioral Symptoms;Biological Assay;Brain;causal variant;Cell membrane;cell type;Cells;cellular pathology;Central Nervous System;citrate carrier;Citrates;Code;Complex;Cytoplasm;Data;Defect;design;Development;developmental epileptic encephalopathy;Disease;disease model;DNA;Drosophila genus;early onset;Electroencephalography;Electrophysiology (science);Epilepsy;epileptiform;fly;gain of function;gene therapy;Genes;Genetic;genome editing;Genotype;Human;Human Genetics;Immunohistochemistry;individualized medicine;interdisciplinary approach;Knock-out;Knockout Mice;Life;loss of function;Measures;Metabolism;metabolomics;Methods;Missense Mutation;Modeling;Molecular;Molecular Genetics;motor symptom;mouse genetics;mouse model;Mus;mutant;Mutation;Nature;neural circuit;Neurobehavioral Manifestations;Neuronal Dysfunction;Neurons;neurotransmitter metabolism;Neurotransmitters;novel;novel therapeutic intervention;Oligodendroglia;Partial Epilepsies;patch clamp;Pathogenicity;Pathway interactions;Patients;Phenotype;Physiological;Physiology;Plasma;Point Mutation;preclinical study;Proteins;recessive genetic trait;Recurrence;reduce symptoms;Research;RNA Interference;Rodent;Role;Seizures;Severities;Slice;Structure;Syndrome;System;Techniques;Testing;Therapeutic;Therapeutic Intervention;Tissues;Toxic effect

PROJECT_TITLE: Genetic and Functional Mechanisms in Citrate Transporter Disorder associated with SLC13A5

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Contraception/Reproduction;Genetics;Mental Health;Neurosciences;Pediatric

ORG_CITY: Aurora

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PI_NAMEs: BALE, TRACY L (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Adolescence;Adolescent;Adverse event;Affect;allostasis;assisted reproduction;Behavioral;Biology;blood-brain barrier permeabilization;Brain;Cell Culture System;Cell Nucleus;Cells;Child;Chronic stress;Communities;Development;disorder risk;Elderly;Electrophysiology (science);Embryo;Embryo Transfer;Embryonic Development;Environment;Epididymis;Epigenetic Process;Epithelial Cells;executive function;experience;Exposure to;Extracellular Matrix;extracellular vesicles;Fertilization;fetal;Fetal Development;Fiber;Functional disorder;Future Generations;gamma-Aminobutyric Acid;gene environment interaction;Generations;Germ Cells;Germ Lines;Glucocorticoid Receptor;Glutamates;Hearing;Histones;Home;Human;Hypothalamic dysfunction;Hypothalamic structure;In Vitro;in vivo;Infection;insight;intergenerational;Intracytoplasmic Sperm Injections;juvenile animal;Link;male;Malnutrition;Microinjections;MicroRNAs;Mitochondria;Modeling;mouse model;Mus;neurodevelopment;Neurodevelopmental Disorder;Neurons;neuropsychiatric disorder;next generation;novel;offspring;Oocytes;Outcome;Performance;Phenotype;Photometry;piRNA;Pregnancy;Proteins;Reaction Time;Recovery;Regulation;Reproductive Techniques;reproductive tract;Research;response;Risk;Role;Signal Transduction;Slice;Smell Perception;Social isolation;Specificity;sperm cell;Stress;stress reactivity;Structural Protein;synaptic function;Technology;Testing;tool;transcriptome;Transfer RNA;Transgenic Mice;transmission process;zygote

PROJECT_TITLE: Paternal stress epigenetic programming of offspring neurodevelopment

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Pulmonary Fibrosis

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE This project explores the effect of chitin, a widespread environmental polysaccharide, on the post-acute sequelae (PASC) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Since chitin is normally degraded by chitinases present in the airways of mice and humans, we will characterize chitinase-producing epithelial cells in mouse models of SARS-CoV-2 infection, and test whether altering chitinase activity influences the severity and persistence of disease induced by SARS-CoV-2 infection. Understanding how environmental chitin influences long-lasting pathology after SARS-CoV-2 infection may lead to the identification of new biomarkers and therapeutic targets associated with PASC and differential COVID-19 disease outcomes.

PI_NAMEs: VAN DYKEN, STEVEN  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;ACE2;Acute;acute COVID-19;Address;Affect;age related;Air;Airborne Particulate Matter;airway epithelium;Antibodies;Area;Attenuated;Binding;biomarker identification;Cardiovascular Diseases;Cessation of life;Chitin;Chitinase;Chronic;Clinical;Coronavirus;Coughing;COVID-19;COVID-19 mortality;COVID-19 pandemic;COVID-19 severity;cytokine release syndrome;Data;demographics;Deposition;Diabetes Mellitus;Dictyoptera;Disease;Disease Outcome;Disease Progression;Dyspnea;Elderly;Environment;Environmental Exposure;Environmental Risk Factor;enzyme therapy;Epithelial Cells;epithelial injury;Epithelium;ethnic minority population;Exhibits;Exposure to;Fever;fibrotic lung disease;Functional disorder;gain of function;global health;Health;House Dust Mite Allergens;Housing;Human;Hypertension;illness length;Immune response;Impairment;improved;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inhalation;Injury;innovation;Integration Host Factors;Link;Long-Term Effects;loss of function;Lung;Lung Diseases;Lung immune response;Mediating;Molds;Molecular;mortality;mouse model;Mus;new therapeutic target;novel;novel therapeutic intervention;pandemic disease;particle;Pathologic;Pathology;Pathway interactions;patient stratification;Patients;Pattern;Phase;Physiology;Polymers;Polysaccharides;Population;post SARS-CoV-2 infection;Post-Acute Sequelae of SARS-CoV-2 Infection;predictive marker;Process;Pulmonary Fibrosis;Pulmonary Pathology;Race;receptor;Recombinants;Recovery;Reporter;Respiratory Disease;Respiratory Failure;response;restoration;Risk;Role;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;severe COVID-19;Severities;Severity of illness;Testing;Therapeutic;therapeutic target;TMPRSS2 gene;transgene expression;Translations;treatment strategy;United States;Viral;Viral Respiratory Tract Infection;Virus Diseases

PROJECT_TITLE: Chitin and chitinases in SARS-CoV-2 infection

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Machine Learning and Artificial Intelligence;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Women's Health Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Among community-living older adults, falls are a leading cause of injury, disability, injury-related death, and high medical costs. Using data from the Centers for Medicare & Medicaid Services and data collected from over 12,000 women enrolled in the Women’s Health Study who wore an accelerometer during waking hours for a week, we will evaluate if metrics of daily living gait and physical activity inform the prediction of injurious falls.

PI_NAMEs: HAUSDORFF, JEFFREY M;LEE, I-MIN ;WAYNE, PETER MICHAEL (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acceleration;Accelerometer;Activities of Daily Living;Address;Adult;Affect;Age;age related decline;Aging;Body mass index;Brain;Cardiovascular system;Characteristics;Clinic;Clinical;Clinical Management;Cognition;Cognitive;cohort;Cohort Studies;community living;Complex;cost;Data;Dementia;Developed Countries;digital assessment;Digital biomarker;digital medicine;disability;Dual-Energy X-Ray Absorptiometry;Early identification;Early Intervention;Enrollment;Event;evidence base;Exercise;fall injury;Fall prevention;fall risk;falls;Future;Gait;Gait speed;Health;high risk;Hip region structure;Hour;Human Resources;Hypertension;Individual;Injury;injury-related death;instrument;Intervention;Knowledge;Laboratories;large datasets;lifestyle factors;Link;Machine Learning;Measures;Medical Care Costs;Metabolic;mortality;Motion;Motivation;multidisciplinary;Muscle;muscle form;Musculoskeletal;Nursing Homes;Occupations;older adult;older women;Outcome;outcome prediction;Patient Self-Report;Performance;Persons;Physical activity;Physiological;Pilot Projects;Prevention strategy;Public Health;public health priorities;Recording of previous events;Records;remote monitoring;Research;respiratory;Risk;Risk Estimate;skeletal;Smoking;Societies;Speed;statistical and machine learning;System;Time;time use;tool;Training;United States Centers for Medicare and Medicaid Services;Visit;Walking;wearable device;wearable monitor;Woman;Women's Health;Women's study;Work

PROJECT_TITLE: Using instrumented everyday gait to predict falls in older adults using the WHS cohort

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative: Achieving a more complete understanding of the neural circuits, receptors and signal transduction pathways in the mammalian brain is crucial for further development of effective therapeutic treatments and the identification of novel drug targets for affective disorders including anxiety. The studies here have the potential to open new pharmacological avenues for targeting the noradrenergic system for psychiatric illnesses.

PI_NAMEs: BRUCHAS, MICHAEL R. (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: acute stress;Affect;Affective;Anatomy;Anxiety;anxiety-like behavior;Arousal;avoidance behavior;Behavior;behavior influence;behavior measurement;Behavioral;behavioral response;beta-adrenergic receptor;Biological Assay;Biosensor;Blood Pressure;Brain;Calcium;cell type;Cells;Characteristics;Control Locus;Darkness;Data;Development;differential expression;Disease;Dissociation;Electrophysiology (science);Environment;Exhibits;experimental study;Exposure to;Fiber;Frequencies;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;Gene Expression Profile;Genetic Transcription;Heart Rate;Heterogeneity;Hippocampus;Holography;Image;imaging approach;In Situ Hybridization;in vivo;Individual;interdisciplinary approach;Light;Link;Literature;Location;locus ceruleus structure;Machine Learning;Measures;Mediating;Mental disorders;Mental Health;Molecular;Molecular Profiling;Mood Disorders;National Institute of Mental Health;Nature;negative affect;neural;neural circuit;Neurons;Neuropeptides;Neuropharmacology;Neurosciences;neurotransmission;new therapeutic target;noradrenergic;Norepinephrine;operation;optogenetics;Organism;Outcome;Output;Pathway interactions;Peptides;pharmacologic;Phase;Photometry;Physiological;Play;Population;Process;Property;Publishing;receptor;Regulation;Reporting;Respiration;response;Rewards;Risk;Role;sensor;Series;Signal Transduction;Signal Transduction Pathway;single-cell RNA sequencing;Slice;Stimulus;Stress;stressor;System;Testing;therapeutically effective;therapy development

PROJECT_TITLE: Decoding Locus Coeruleus Neural Circuits and Signaling In Negative Affect