NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Epilepsy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: The proposed research is relevant to public health because seizures affect approximately 4 million people with epilepsy in the United States. The project is relevant to the NINDS mission of reducing the burden of neurological disease. Noninvasive forecasting of seizures could profoundly improve the quality of life, decrease injuries and decrease mortality.

PI_NAMEs: GOLDENHOLZ, DANIEL M (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acceleration;Affect;Age;aged;Applied Research;Artificial Intelligence;artificial intelligence algorithm;Automobile Driving;Biometry;Biosensor;Brain;Calibration;Cessation of life;Clinical;cohort;comorbidity;computer science;Data;Data Science;deep learning;design;Development;diaries;digital;Disease;Dose;Drug resistance;Education;Electroencephalography;Electronics;Emergency department visit;Epilepsy;Exercise;experience;follow-up;Foundations;Frequencies;Fright;Goals;Heart Rate;high risk;Hormonal;Hormones;Hospitalization;Hour;Humidity;Impact Seizures;improved;Informatics;Injury;Intractable Epilepsy;K-Series Research Career Programs;Knowledge;Laboratories;Location;longitudinal dataset;Machine Learning;machine learning algorithm;medication compliance;Menstrual cycle;Mentors;Mentorship;meteorological data;Methods;Mission;Monitor;Morbidity - disease rate;mortality;multimodality;National Institute of Neurological Disorders and Stroke;neglect;Nervous System Disorder;online course;Outcome;Outcome Study;Participant;Pathway interactions;Patients;Pattern;Persons;Pharmaceutical Preparations;Physicians;Predisposition;prospective;Public Health;Quality of life;Reporting;Research;Research Personnel;Research Project Grants;Risk;risk prediction;Running;Safety;Seizures;side effect;skills;Sleep;Sleep Deprivation;Sleep Fragmentations;Stress;System;systematic review;Techniques;Technology;Temperature;Temporal Lobe Epilepsy;Time;tool;tool development;Training;translational impact;United States;Validation;wearable device;wearable sensor technology;Weather;weather patterns;Work;Wrist

PROJECT_TITLE: Non-Invasive Seizure Forecasting System Using E-Diaries, Internal and External Factors


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: COLLEGE PARK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ZOOLOGY

ORG_FIPS: US

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative Regulatory genes that control embryonic development are shared among diverse species because changes in their basic functions are highly deleterious. Surprisingly, we found that the genes controlling a fundamental feature of the insect body plan – segmentation – have changed during insect evolution, with genes gained, lost or changed in function. We explore the evolutionary and molecular mechanisms underlying these changes, which have allowed for seamless re-wiring of regulatory interactions, and develop tools to examine a cohort of segmentation genes in new insect model systems that use different genes for early patterning than the established model Drosophila melanogaster.

PI_NAMEs: PICK, LESLIE  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Address;Alleles;Animals;Anopheles Genus;Anterior;base;Biological Models;Black Currant;Body Patterning;Butterflies;Chromatin Structure;Cis Tests;cohort;Comparative Study;CRISPR/Cas technology;Culicidae;Defect;design;Development;Drosophila genus;Drosophila melanogaster;Embryo;Embryonic Development;Evolution;experimental study;FAIRE sequencing;Family member;Gene Expression;gene function;gene network;gene regulatory network;Gene Structure;Gene Transfer Techniques;Genes;Genetic;genetic approach;genetic evolution;Genetic Screening;Genetic Variation;Genome;genome editing;genomic tools;graduate student;Hand;Health;Homozygote;Human;In Situ Hybridization;Individual;Insecta;insight;Investments;Lepidoptera;Maintenance;malaria mosquito;Modeling;Molecular;Molecular Biology;Molecular Evolution;Molecular Genetics;Morphogenesis;Morphology;mutant;Mutation;Nature;novel;Nucleic Acid Regulatory Sequences;Orthologous Gene;Pattern;Pigmentation physiologic function;post-doctoral training;Postdoctoral Fellow;Protocols documentation;Radiation;Receptor Gene;Regulator Genes;Resources;Risk;RNA Interference;Sampling;Specific qualifier value;Standardization;System;Systems Development;Techniques;Testing;tool;tool development;trait;transcription factor;transcriptome sequencing;translational study;undergraduate student;Work

PROJECT_TITLE: Functional evolution of segmentation gene regulatory networks in insects

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Neurodegenerative diseases exact a significant toll on national healthcare resources, and on the patients and caregivers directed affected by these devastating disorders. The studies proposed here will take powerful, innovative approaches to better understand how these diseases arise and progress, with the goal of developing safe and effective therapies for Parkinson's disease, Alzheimer's disease and related neurodegenerative disorders.

PI_NAMEs: FEANY, MEL B (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: Affect;Age;age related neurodegeneration;alpha synuclein;Alzheimer's Disease;Ankyrins;Autophagosome;Autopsy;beta Spectrin;Binding;Biological Models;brain tissue;Caregivers;cell type;Cells;Complement;Cytoskeleton;Disease;disease model;dopaminergic neuron;Drosophila genus;effective therapy;fly;Gene Expression;Genes;genetic analysis;genetic manipulation;Genetic Screening;Genetic Transcription;genome-wide;Goals;Healthcare;innovation;Modeling;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurons;neurotoxicity;Parkinson Disease;Pathology;Patients;Play;Population;Resources;Role;Specificity;Spectrin;synucleinopathy;System;Testing;Therapeutic;Toxic effect

PROJECT_TITLE: Genetic Analysis of Neurodegeneration


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anorexia;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Opioids;Pediatric;Precision Medicine;Serious Mental Illness

ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

ORG_STATE: MO

PHR: Project Narrative Eating disorders are common in adolescents, increase the risk of substance use, have the highest mortality rate of any psychiatric illness and are not responsive to current pharmacotherapy. The overall goal of this K23 proposal is to evaluate neuroimaging as a pharmacodynamic biomarker of opioid antagonism in adolescents with eating disorders through practical application of training in neuroimaging, pediatric randomized clinical trials and exposure-response modeling. At the completion of this proposal, Dr. Stephani Stancil will be well- positioned for an independent career as an interdisciplinary translational scientist focused on pharmacodynamic biomarker development to support early-stage drug development in pediatric neuropsychopharmacology.

PI_NAMEs: STANCIL, STEPHANI L (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Active Learning;Address;Adolescence;Adolescent;adolescent mental health;Adult;Affect;aged;alternative treatment;Anorexia Nervosa;antagonist;Anterior;Award;Binge Eating;Binge eating disorder;binge type behavior;Biological Markers;biomarker development;biomarker validation;Brain;brain reward regions;Bulimia;Cardiac;career;career development;Central Nervous System Agents;Child;Childhood;cingulate cortex;Clinical;Clinical Pharmacology;Clinical Sciences;Clinical Trials;craving;Cross-Over Studies;Cross-Over Trials;Data;Death Rate;design;Development;Development Plans;Dorsal;Dose;drug action;Drug Design;drug development;drug discovery;Drug Exposure;Drug Kinetics;drug repurposing;Eating Behavior;Eating Disorders;efficacy trial;Environment;Enzymes;Food;frontier;Functional disorder;Functional Magnetic Resonance Imaging;Future;Genetic Variation;Goals;Hour;imaging facilities;Individual;interest;Intervention;Joints;K-Series Research Career Programs;Link;male;Malnutrition;Medical center;medical schools;Mental disorders;Mental Health;Mentors;model development;Modeling;Morbidity - disease rate;Naltrexone;National Institute of Mental Health;neuroimaging;neuroimaging marker;Neuropharmacology;neuropsychopharmacology;Obesity;Opioid;Opioid Antagonist;Opioid Receptor;Pathway interactions;Patients;pediatric department;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;pharmacologic;Pharmacotherapy;Placebo Control;Plasma;Play;pleasure;Positioning Attribute;practical application;Precision therapeutics;psychopharmacologic;purge;purging behavior;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;research and development;Research Institute;Research Personnel;response;response biomarker;Rewards;Risk;Role;Sampling;Site;skill acquisition;Structure;substance use;Substance Use Disorder;System;Taste Perception;Teenagers;Therapeutic;Training;Translational Research;translational scientist;Visualization;Vomiting;Vulnerable Populations

PROJECT_TITLE: Development of a Pharmacodynamic Biomarker of Opioid Antagonism in Adolescents with Eating Disorders

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Services;Mental Health;Pediatric;Prevention

ORG_CITY: DURHAM

ORG_NAME: 3-C INSTITUTE FOR SOCIAL DEVELOPMENT

ORG_STATE: NC

PHR: Project Narrative Schools are the most common setting for mental health (MH) service delivery to children and adolescents; unfortunately, school health and MH professionals face a number of barriers to using validated MH screening tools, including lack of familiarity with and access to established measures, scoring and interpretation challenges, and limited time and resources to set up and administer MH assessment. These impediments contribute to the disturbing fact that two out of three youth with a diagnosable MH problem in the U.S. do not get the help they need, leading to heightened risk for chronic MH problems as well as school failure, family problems, and risky behaviors (e.g., substance use). The goal of this Direct to Phase II SBIR is to increase access to and use of established high quality MH and MH-related assessment measures in schools which, in turn, has the potential for broad-reaching public health impact for youth and families.

PI_NAMEs: DEROSIER, MELISSA E. (contact);HOOVER, SHARON H

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Administrator;Adolescent;Adoption;Age;Anxiety;Assessment tool;barrier to care;Child;Chronic;Clinical;Collaborations;commercial application;commercial launch;Communities;Computer software;cost;COVID-19 pandemic;dashboard;Data;Data Collection;Data Display;Data Reporting;Decision Aid;Decision Making;depressive symptoms;design;Development;Disease;Drug usage;Early identification;empowerment;Ensure;Evaluation;evidence base;experience;Face;Failure;Familiarity;Family;field study;Foundations;Fright;gaps in access;Goals;Health;health assessment;health care delivery;health data;Health Personnel;Health Professional;Health Services;improved;Infrastructure;Investments;K-12 student;Libraries;Loneliness;Marketing;Measures;Mental Depression;Mental Health;mental health personnel;Mental Health Services;mental set;novel;Performance;Phase;pilot test;Problem behavior;Provider;Public Health;public health emergency;Recommendation;Reporting;Research;Resources;response;Risk;Risk Behaviors;Schedule;school health;Schools;screening;Screening procedure;Secure;Service setting;Services;skills;Small Business Innovation Research Grant;Social isolation;social stigma;software systems;Solid;Students;substance use;support tools;Surgeon;Surveys;System;Technology;Technology Assessment;Teenagers;Testing;Time;tool;Trauma;usability;Work;Youth

PROJECT_TITLE: Integrated software platform to enhance school mental health assessment and data-driven student services


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: ITHACA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Obesity is associated with ovulation failure and negatively impacts the function of ovarian blood vessels in women; however, the mechanisms by which obesity increases the risk of ovulation failure are not fully understood, and in particular, it is not known whether obesity impedes necessary changes in ovarian vascular function leading up to ovulation. This research will produce new understanding of how ovarian vascular function is regulated at the cellular and molecular levels and how obesity impacts these processes required for ovulation. This knowledge will support the design of novel infertility treatments that can benefit millions of women.

PI_NAMEs: REN, YI  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: 3-Dimensional;Abbreviations;Ablation;Address;Affect;Age;Animals;Blood flow;Blood Vessels;CCAAT-Enhancer-Binding Protein-alpha;cell type;Chromatin;constriction;Data;data integration;Data Set;Defect;design;diet-induced obesity;effective therapy;Epigenetic Process;epigenetic regulation;Event;experimental study;Failure;female fertility;Female infertility;Fertility;Foundations;Gene Expression;Genes;genomic data;Goals;granulosa cell;Image;Impairment;improved;in vivo;Infertility;infertility treatment;innovation;insight;intravital imaging;Knowledge;Link;Luteinizing Hormone;Maps;Mediating;Mediator;Metabolism;Methodology;Methods;Molecular;Morphogenesis;mouse model;multiphoton microscopy;Mus;mutant;Mutant Strains Mice;novel;Obesity;Outcome;Ovarian;Ovary;Ovulation;Permeability;phenotypic data;Physiological Processes;Play;Process;proliferative phase Menstrual cycle;Regulation;reproductive;Research;response;Risk;Role;Rupture;Series;Signal Pathway;Signal Transduction;single cell ATAC-seq;single cell sequencing;single nucleus RNA-sequencing;Site;spatiotemporal;Technology;Testing;Time;transcription factor;Transcriptional Regulation;Transgenic Mice;United States;Vascular Endothelial Cell;Vascular Permeabilities;Vascular remodeling;Woman;women's treatment

PROJECT_TITLE: Control of ovarian vascular remodeling by CCAAT/enhancer binding proteins alpha and beta

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PUBLIC HEALTH RELEVANCE: Telomeres are specialized structures located at the ends of chromosomes that fulfill an essential role in maintaining the structural and genetic integrity of the genome. Telomeres do this by controlling the number of times each cell can divide. Once a cell becomes damaged or acquires a potentially harmful mutation, telomeres signal to other proteins that elicit a permanent cessation of cell division. This prevents the development of cancer. However, mutations can bypass this arrest in cell division and re-initiate cellular division. These cells must also re-activate a mechanism that ensures that telomeres once again maintain the structural integrity of chromosomes but are no longer capable of blocking cell division. This is achieved by activating one of two different telomere maintenance mechanisms. One of these mechanisms is known as alternative lengthening of telomeres, or simply ALT. Cancers that rely on ALT tend to be among the most aggressive and patients often have a poor prognosis. Therefore, understanding the molecular basis for the activation and maintenance of the ALT pathway and identifying the key regulators of ALT is critically important for improving the detection and treatment of this devastating disease. We have identified an essential mediator of ALT telomere maintenance named HIRA. We show that deletion of HIRA or attenuating its function is capable of killing cancer cells that rely on ALT. Developing a greater understanding of the molecular function of HIRA and evaluating its potential as a cancer therapy target is the focus of our study.

PI_NAMEs: O'SULLIVAN, RODERICK  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Acute;Adopted;ADP ribosylation;Affect;ATRX gene;Automobile Driving;Bypass;cancer cell;Cell Cycle;Cell division;Cells;Cessation of life;Chromatin;Chromatin Modeling;chromatin remodeling;Chromatin Remodeling Factor;Chromosomes;Cleavage Under Targets and Release Using Nuclease;Compensation;Complex;cytotoxicity;Data;DAXX gene;Dedications;Deposition;Detection;Development;Disease;Disseminated Malignant Neoplasm;DNA Damage;DNA Sequence Alteration;Enhancers;Ensure;Epigenetic Process;epigenome;epithelial to mesenchymal transition;Event;Exhibits;G2 Phase;gain of function;Genes;Genetic;Genetic Transcription;genome integrity;Genomic approach;genomic locus;Glioma;Histone H3.3;histone modification;improved;innovation;loss of function mutation;Maintenance;Malignant Neoplasms;Mediating;Mediator;Metabolic;Microscopy;Missense Mutation;Modeling;Molecular;Mutation;Names;Nucleosomes;Patients;prevent;Prognosis;promoter;Property;Proteins;Proteomics;public health relevance;reconstitution;recruit;Recurrence;Regulation;repaired;Reporting;response;Role;Signal Transduction;Stress;Structure;targeted cancer therapy;telomere;Telomere Maintenance;Telomere Pathway;therapeutic target;trait;tumor;tumorigenesis;ultra high resolution

PROJECT_TITLE: Co-Regulation of Alternative Lengthening of Telomeres and Chromatin Dynamics in ATRX-DAXX deficient cancer cells

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: HOUSTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative Imaging specific biological processes in cells is a fundamental capability for researchers and clinicians in the disease diagnosis and monitoring of therapeutic cells. This proposal builds on the recently introduced ultrasound- based reporter genes and aims to innovate the mechanical properties of these proteins to achieve substantially higher imaging sensitivity. The utility of these newly designed proteins will be tested in vitro and in rodent models.

PI_NAMEs: LU, GEORGE J (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Acoustics;Adoption;Alanine;Amino Acids;Animal Model;Award;Benchmarking;Biological Process;Biology;Biomedical Research;Caenorhabditis elegans;Carbamates;Cell Therapy;Cells;cellular imaging;Chemicals;Chemistry;crosslink;design;Detection;Diagnosis;Diagnostic;Disease;disease diagnosis;Elements;Engineering;Ensure;Escherichia coli;Evaluation;Exploratory/Developmental Grant;fluorescence imaging;Funding Mechanisms;Gases;Gene Expression;Generations;Genes;Genetic Code;Goals;hemodynamics;high risk;Human;Image;imaging agent;imaging biomarker;improved;in vitro testing;innovation;interdisciplinary approach;Light;Lysine;Mammalian Cell;Maps;Mass Spectrum Analysis;Measurement;Measures;mechanical properties;Mechanics;Methods;Microbe;Microbubbles;Modeling;Monitor;monomer;Movement;Mutagenesis;Names;Nanostructures;new technology;non-invasive imaging;Organism;Outcome;particle;Penetration;Phase;pressure;Process;Property;Protein Engineering;Proteins;Protocols documentation;Reporter;Reporter Genes;Research Personnel;Resistance;Rodent;Rodent Model;Rupture;Scientist;screening;Signal Pathway;simulation;Site;Solid;Stress;Structural Models;Structure;submicron;synthetic biology;targeted imaging;Technology;technology development;Tensile Strength;Therapeutic;Time;Tissues;tool;Ultrasonography;ultrasound;Vesicle;Visualization

PROJECT_TITLE: Ultrasensitive acoustic reporter proteins with engineered rupture-resistant shells

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: SAINT LOUIS UNIVERSITY

PHR: Project Narrative The proposed studies address the structural underpinnings of the activation of factor V by thrombin leading to initiation of the blood coagulation response. Progress in this area will impact basic knowledge of the pathophysiology of blood coagulation and its therapeutic control.

PI_NAMEs: DI CERA, ENRICO  (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: activated Protein C;Active Sites;Address;Architecture;Area;Autolysis;Binding;Biological;Blood coagulation;Blood Coagulation Factor;C2 Domain;Coagulation Process;cofactor;Complex;Cryoelectron Microscopy;Development;Disease;Docking;Enzymatic Biochemistry;Enzyme Interaction;Enzyme Precursors;enzyme structure;Enzymes;Epitopes;Equilibrium;Factor V;Factor Va;Factor Xa;Functional disorder;Goals;Hemostatic function;Human;Investigation;Knowledge;Kringles;Length;macromolecule;Maps;meizothrombin;Membrane;Molecular;Molecular Conformation;Mutagenesis;Mutation;novel therapeutic intervention;novel therapeutics;Pathway interactions;Peptide Hydrolases;Phase;Physiological;Positioning Attribute;Protease Domain;Proteins;Prothrombin;prothrombinase complex;Research Project Grants;Resolution;response;Site;Site-Directed Mutagenesis;structural biology;structural determinants;Structure;success;Surface;System;Tertiary Protein Structure;Testing;Therapeutic;Thrombin;Thrombosis;Time;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Structural enzymology of factor V activation


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Osteoporosis is a prevalent disease characterized by low bone mineral density, bone fragility, and fractures. Mice lacking the potassium ion channel Girk3 have elevated bone mass and reduced circulating cytokines in adulthood, making Girk3 a novel target for bone remodeling. This research will determine the physiological and cellular mechanisms by which Girk3 regulates cytokine production and bone mass and test whether Girk3 deletion prevents ovariectomy-induced osteoporosis in a cytokine-dependent manner.

PI_NAMEs: WEAVER, SAMANTHA R (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Adult;Affect;Age;aged;aging process;Applied Skills;Award;Bioinformatics;Biological Assay;Biological Markers;Biology;Blood;bone;bone cell;Bone Density;Bone Development;Bone Diseases;bone fragility;bone loss;Bone Marrow;Bone Marrow Cells;bone mass;Bone remodeling;Bone Resorption;Calvaria;career;career development;Cell Lineage;Cells;Cellularity;Clinic;Continuous Infusion;cytokine;Cytometry;Data;Development;Development Plans;Disease;Educational workshop;Endocrinology;Enzyme-Linked Immunosorbent Assay;experimental study;Female;Foundations;Fracture;Goals;GTP-Binding Proteins;Harvest;Hematopoietic;IL3 Gene;improved;In Vitro;Inflammation Process;Inflammatory;innovation;Interleukin-1;Interleukin-1 beta;inward rectifier potassium channel;Ion Channel;Ion Channel Gating;Ions;Knowledge;Laboratories;Lead;Learning;Macrophage;male;Measures;Mechanics;meetings;Membrane;men;Mentors;Mentorship;Messenger RNA;Methods;microCT;Modeling;Molecular;monocyte;mouse model;Mus;Musculoskeletal;novel;old mice;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis;Osteoporosis;osteoporosis with pathological fracture;Ovariectomy;Phase;Physiological;Physiological Processes;Population;Positioning Attribute;Postdoctoral Fellow;Postmenopausal Osteoporosis;Potassium;Potassium Channel;pre-doctoral;prevent;Production;programs;Publications;Publishing;Research;research and development;Research Personnel;Role;Safety;Serum;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skeletal;Skeleton;skills;success;symposium;synergism;Testing;Time;tool;Training;transcriptome;transcriptomics;Wild Type Mouse;Woman;Work

PROJECT_TITLE: Girk3 in bone biology and disease

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: HERSHEY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project narrative: This project will test for differences in emotion dynamics (e.g., within-day negative affect variability and emotion differentiation) across NIAAA recovery (e.g., cessation of heavy drinking and remission from DSM-5 AUD) phases examine associations between amotion dynamics and alcohol consumption between and within NIAAA recovery phases. Study findings have the potential to provide critical information that can serve to identify optimal timing of intervention and re-intervention during different recovery periods, prepare patients for affective changes that may occur during AUD recovery, and inform longitudinal studies that examine trajectories of relapse and recovery in the long-term.

PI_NAMEs: LINN, BRADEN K (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Adolescent;Affect;Affective;Alcohol consumption;alcohol use disorder;Alcohols;Borderline Personality Disorder;Categories;chronic alcohol ingestion;cohort;Consumption;Data Collection;Development;Diagnosis;Disease remission;drinking;DSM-V;emotion regulation;Emotional;emotional functioning;Emotions;Enrollment;Frequencies;Future;Health;Heavy Drinking;Impulsivity;Individual;Intervention;Knowledge;Label;Literature;Longitudinal Studies;Maintenance;Mental disorders;Methods;Moods;National Institute on Alcohol Abuse and Alcoholism;Nature;negative affect;Patients;Personal Satisfaction;Phase;Process;psychologic;Recovery;Recovery of Function;recruit;Regulation;Relapse;Reporting;response;Role;Sampling;Smoking;Stress;Substance abuse problem;substance use;Testing;text searching;theories;Time;uptake;Work

PROJECT_TITLE: Emotion dynamics and alcohol use in NIAAA-defined recovery from alcohol use disorder

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: TR

ED_INST_TYPE: SCHOOLS OF LAW OR CRIMINOLOGY

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative This project is relevant to public health because it will assess the actual level of use and ethical nature of certain techniques used to recruit human subjects in clinical trials, and, if appropriate, recommend steps to better protect participants in the process of recruitment and obtaining informed consent.

PI_NAMEs: KAPHINGST, KIMBERLY A;MEHLMAN, MAXWELL J (contact)

PROGRAM_OFFICER_NAME: COLLIER, ELAINE S

PROJECT_TERMS: Address;Adult;Architecture;arm;Attitude;Awareness;behavioral economics;Bioethics Consultants;Biomedical Research;Black race;Calories;Clinical Research;Clinical Trials;Coercion;community engagement;Consent;Consent Forms;Data;design;Educational workshop;effectiveness clinical trial;effectiveness evaluation;Empirical Research;Enrollment;Ethics;fast food;Goals;Grant;human subject;Human Subject Research;Informed Consent;insight;Institutional Review Boards;Intervention;Interview;Knowledge;Latinx;Lead;Legal;Literature;member;Methods;minimal risk;Nature;Odds Ratio;Participant;Patients;Perception;Personal Behavior;Persons;Phase;Physicians;Policies;Policy Making;policy recommendation;Population Heterogeneity;Process;Public Health;Randomized;Recommendation;recruit;Recruitment Activity;Reporting;Research;Research Personnel;research study;response;Risk;risk/benefit ratio;screening;Site;Structure;Suggestion;Support Groups;Surveys;Techniques;Testing;Translational Research;translational scientist;undue influence;Universities;Utah;volunteer

PROJECT_TITLE: Using Nudges to Recruit Human Subjects in Clinical & Translational  Research


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Depression;Mental Health;Neurosciences;Pain Research

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Narrative The goal of this project is to understand the molecular mechanisms and physiological roles of store-operated calcium channels for Ca2+ signaling in neurons and astrocytes, and examine implications for brain pathologies including inflammation-induced depression and neuropathic pain. Findings from these studies will provide new mechanistic insights into Ca2+ signaling pathways controlling neuronal and astrocyte function, and could in the long run, yield a new therapeutic target for brain diseases.

PI_NAMEs: PRAKRIYA, MURALI  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Address;Architecture;Astrocytes;Behavioral;Brain;Brain Diseases;Brain Pathology;Calcium;Calcium Channel;Cell membrane;Cells;Cognition;Communication;cytokine;Dependence;Disease;drug discovery;Electrophysiology (science);Endoplasmic Reticulum;Etiology;Exhibits;Gene Expression;Genetic Transcription;Goals;Immune;immunodeficiency;Inflammation;insight;Ion Channel;Knockout Mice;Learning;Mediating;member;Memory;Mental Depression;Metabolism;Modeling;Molecular;molecular dynamics;Myopathy;Nervous System;Nervous System Disorder;Neuroglia;Neurons;neurotransmitter release;Neurotransmitters;new therapeutic target;nuclear factors of activated T-cells;Pain;painful neuropathy;Pathway interactions;Physiological;Physiology;Process;Property;Protein Isoforms;Receptor Signaling;Regulation;Role;sensor;Signal Pathway;Signal Transduction;Site;STIM1 gene;Synapses;Synaptic plasticity;Work

PROJECT_TITLE: The Physiology of Store-Operated Channels in the Nervous System


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative CDC34 and SCF/CRL E3 ligases function together to control myriad cellular processes such as cell cycle progression, a process essential to life that when dysregulated is a defining feature of cancer cells. CRL E3 ligases are also hijacked by PROTAC molecules which harbor therapeutic potential by inducing degradation of proteins of interest that contribute to human disorders. Successful completion of the proposed studies will reveal the molecular mechanisms by which Cdc34 and SCF/CRL E3s function together as essential regulators of key cellular processes and will provide a platform for development of novel cancer therapeutics.

PI_NAMEs: OLSEN, SHAUN  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: 3-Dimensional;Active Sites;Affinity;Architecture;BCL1 Oncogene;BCL2L1 gene;Biochemical;Biological Assay;Biological Process;Biophysics;cancer cell;Cardiovascular Diseases;Catalysis;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Physiology;Cells;Cellular biology;Chemicals;Complex;crosslink;Cryoelectron Microscopy;Cullin Proteins;Data;design;Development;Disease;DNA Repair;Elements;Engineering;Enzymes;Eukaryotic Cell;experimental study;F Box Domain;Family;FDA approved;functional outcomes;genetic regulatory protein;Goals;Hand;Health;Human;Human Pathology;Immune System Diseases;Immunity;In Vitro;insight;interest;intermolecular interaction;KRAS2 gene;lens;Life;Link;Lysine;Malignant Neoplasms;Mediating;member;Methionine;Molecular;Multiple Myeloma;N-terminal;novel;novel therapeutics;Pathology;Patients;Pharmaceutical Preparations;Play;Polymers;Polyubiquitin;Positioning Attribute;Post-Translational Protein Processing;Process;Property;Protac;protein degradation;Protein Degradation Induction;Proteins;reconstitution;reconstruction;recruit;Secure;Signal Transduction;single molecule;Specificity;Structure;System;targeted treatment;Techniques;Therapeutic;therapeutic development;Therapeutic Intervention;TRAP Complex;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Variant;X-Ray Crystallography

PROJECT_TITLE: Structure and Function of the Essential Cell Cycle Regulator Cdc34

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: BALTIMORE

ORG_DEPT: BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative We have discovered that distinct PIWI-interacting RNA (piRNA) transcription complexes drive expression of male- and female-specific germline piRNAs. The goal of this proposal is to understand the mechanisms by which sex-specific piRNAs are expressed and regulate endogenous germline genes. We will characterize the distinct male and female piRNA transcription complexes and elucidate the impact that sex-specific piRNAs have on animal fertility, thus providing insights into therapeutic opportunities for human infertility.

PI_NAMEs: KIM, JOHN  (contact)

PROJECT_TITLE: Sexual dimorphism of piRNA transcription and target silencing mechanisms in C. elegans

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Regenerative Medicine;Wound Healing and Care

ORG_CITY: STANFORD

ORG_DEPT: SURGERY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: 8. Project Narrative Scarring is the end result of injury in adult human skin and results in an enormous financial and medical burden for our society, yet no molecular therapies exist that can prevent scarring or its sequelae. While dermal adipose tissue has been proposed to contribute to wound healing via adipocytes transitioning into wound fibroblasts, the role and drivers of adipocyte-to-fibroblast transition in scarring remain poorly understood. Therefore, we propose to explore the biomolecular and tissue mechanical drivers of wound adipocyte-to-fibroblast transition, in order to inform potential novel targets to minimize scarring and promote regenerative wound healing.

PI_NAMEs: LONGAKER, MICHAEL T (contact);WAN, DERRICK

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: adipocyte differentiation;Adipocytes;Adipose tissue;Adopted;Adult;Anatomy;cell type;Cells;Cicatrix;Clinical;Communication;cost;Cutaneous;Data;data integration;Deposition;Dermal;Development;Dipeptidyl-Peptidase IV;epigenomics;Extracellular Matrix;Fibroblasts;Fibrosis;Flow Cytometry;Focal Adhesion Kinase 1;functional loss;Genes;Genetic;Growth;Histologic;Histology;Human;Hypertrophic Cicatrix;image processing;Immunohistochemistry;In Situ;In Vitro;in vivo;Injury;Knockout Mice;Machine Learning;mechanical drive;mechanical force;mechanical signal;Mechanics;mechanotransduction;Medical;Modeling;Molecular;molecular dynamics;molecular phenotype;Morbidity - disease rate;mortality;mouse model;multimodal data;multiple omics;Mus;Myofibroblast;Natural regeneration;new therapeutic target;novel;novel therapeutics;Pathway interactions;Phase;Phenotype;Piezo 1 ion channel;Piezo 2 ion channel;Population;prevent;Process;profibrotic fibroblast;Proteomics;psychosocial outcome;regenerative healing;Regenerative wound healing;Reporting;response;Role;Signal Pathway;Signal Transduction;single cell ATAC-seq;Skin;skin fibrosis;skin healing;skin wound;skin xenograft;small molecule;Societies;subcutaneous;Surface;System;therapeutic target;Time;Tissues;transcriptomics;Transgenic Organisms;translational goal;treatment strategy;United States;Work;wound;wound care;wound environment;wound healing;Wound models;Xenograft Model

PROJECT_TITLE: Defining the role of mechanoresponsive adipocyte-to-fibroblast transition in wound fibrosis.

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: NARRATIVE Alternative approaches to inhibit/suppress/cure HIV-1 infection are needed. The proposed collaborative research program will provide structural details about HIV-1 protein and nucleic acid interactions, with the expectation that strategies for developing improved or new HIV-1 inhibitors will emerge.

PI_NAMEs: GRONENBORN, ANGELA M. (contact);POLENOVA, TATYANA

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;antiretroviral therapy;Area;Award;Binding;Capsid;Capsid Proteins;career;career development;Cell membrane;Cell Nucleus;Cells;Chromatin;chromatin protein;Chronic Disease;Collaborations;Communication;comorbidity;Complex;Computing Methodologies;Cryoelectron Microscopy;Cyclophilin A;Cytoplasmic Tail;Data;Dependence;design;Development;Drug resistance;Drug Targeting;Ensure;expectation;experience;Fostering;fundamental research;Generations;Genome;glycoprotein 41;Goals;graduate student;HIV;HIV-1;HIV/AIDS;Immune Evasion;Immunologic Factors;improved;In Situ;Individual;Infection;inhibitor;insight;Institution;Integrase;Integrase Inhibitors;Integration Host Factors;Knowledge;Laboratories;Length;Mentors;Methodology;Methods;Microscopy;Mission;Modeling;Molecular;Molecular Conformation;National Institute of Allergy and Infectious Disease;NMR Spectroscopy;novel;Nuclear;Nuclear Import;Nucleic Acids;Pathway interactions;Positioning Attribute;Postdoctoral Fellow;Principal Investigator;Productivity;Program Development;programs;protein complex;Proteins;Proviruses;Quality of life;Recombinants;Research;Research Personnel;Research Support;Resistance development;Resolution;Ribonucleoproteins;RNA;Role;Scientist;single molecule;small molecule inhibitor;Structural Biologist;structural biology;Structure;Technology;Time;tool;trafficking;Training;Variant;Viral;Viral Genome;Viral Reverse Transcription;Virion;virology;Virus;virus host interaction;Work

PROJECT_TITLE: Pittsburgh Center for HIV Protein Interactions (PCHPI)


NIH_SPENDING_CATS: HIV/AIDS

PI_NAMEs: GRONENBORN, ANGELA M. (contact)

PROJECT_TERMS: Address;Administrator;Area;Award;Collaborations;Communication;Communities;Data;data sharing;data submission;Databases;Development;Doctor of Philosophy;Ensure;Faculty;Feedback;Foundations;Funding;Gender;Goals;HIV;HIV-1;Human Resources;Individual;Infrastructure;Intellectual Property;Knowledge;Literature;meetings;member;Mission;Molecular;National Institute of Allergy and Infectious Disease;new technology;novel;Nuclear Import;operation;Participant;Pathway interactions;Policies;Postdoctoral Fellow;Process;programs;Proteins;public database;Recording of previous events;Reporting;repository;Research;Research Personnel;Research Priority;Resource Sharing;Sister;Strategic Planning;structural biology;Structure;Students;success;symposium;Technical Expertise;technology development;trafficking;United States National Institutes of Health;Update;Work

PROJECT_TITLE: Administrative Core


PI_NAMEs: SKOWRONSKI, JACEK  (contact)

PROJECT_TERMS: Acceleration;Applications Grants;Articulation;assessment application;Award;career;career development;Career Mobility;Collaborations;Communities;cost;design;Development;Discipline;empowerment;experience;Faculty;Fostering;Funding;Future;Goals;Grant;HIV;HIV-1;improved;Individual;Institution;inter-institutional;Knowledge;Measures;meetings;member;Mentors;Mission;National Institute of Allergy and Infectious Disease;next generation;novel;Polishes;Postdoctoral Fellow;postdoctoral investigator;pre-doctoral;programs;Proteins;Publications;Research;Research Personnel;Science;Scientist;Sister;skill acquisition;skills;Structural Biologist;structural biology;Students;success;symposium;synergism;Talents;Techniques;Training;United States National Institutes of Health;virology;Work;Writing

PROJECT_TITLE: Developmental Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Substance Misuse

ORG_CITY: GALVESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE The proposed project is to study the mechanisms of maternal opioid exposure-associated aberrant brain development and behavioral anomalies in offspring. The outcomes of this study will pave the way toward identification of innovative targets for the development of new treatments or preventive strategies to combat the health effects of opioids during pregnancy.

PI_NAMEs: CUNNINGHAM, KATHRYN A.;WU, PING  (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: Abbreviations;adolescent offspring;Affect;Animal Model;Attention deficit hyperactivity disorder;Behavior;Behavioral;Biochemical;Biological;Brain;brain abnormalities;Brain region;Buprenorphine;buprenorphine treatment;Cells;Central Nervous System;Chronology;Clinical;Clinical Management;Clozapine;cognitive control;combat;Defect;Dependovirus;designer receptors exclusively activated by designer drugs;Development;Disease Management;Dopamine;Embryo;enhanced green fluorescent protein;experience;Exposure to;fetal opioid exposure;Genetic;genetic analysis;Glucuronides;Health;health of the mother;human male;Immunohistochemistry;in utero;In Vitro;in vivo;innovation;Knowledge;Link;male;Male Adolescents;MAP Kinase Gene;Maternal-fetal medicine;Medial;medication for opioid use disorder;Medication Management;Methadone;Microdialysis;Mitogen-Activated Protein Kinases;Molecular;Mothers;Motor Activity;motor control;mouse model;Mus;neonate;nerve stem cell;neural;Neuroanatomy;Neurobiology;neurodevelopment;neurogenesis;Neuroglia;Neurons;Neurophysiology - biologic function;Newborn Infant;Nociception;novel;novel therapeutic intervention;object recognition;offspring;Opioid;Opioid agonist;opioid exposure;opioid mortality;Opioid Receptor;opioid use;opioid use disorder;opioid use in pregnancy;Outcome;Outcome Study;overdose death;Oxides;Oxycodone;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Phenotype;Polymerase Chain Reaction;pre-clinical;Prefrontal Cortex;Pregnancy;pregnant;Pregnant Women;Prevalence;Prevention strategy;Proliferating;Reaction Time;Reporting;Research Personnel;Rewards;Safety;Scientist;sex;small hairpin RNA;standard of care;stem;stem cell biology;stem cell function;stem cells;Structure;Substance Use Disorder;Testing;translational model;Tyrosine 3-Monooxygenase;United States;Ventral Tegmental Area

PROJECT_TITLE: Mechanisms of prenatal opioid exposure on brain and behavior

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


PI_NAMEs: PERILLA JIMENEZ, JUAN ROBERTO (contact)

PROJECT_TERMS: Adoption;base;Binding;Biochemical;Biological Assay;Capsid;Capsid Proteins;Collaborations;Communities;comparative;Complex;Computational Technique;computerized tools;Computing Methodologies;Crowding;Data;design;Development;Disease;Environment;Free Energy;Future;HIV;HIV-1;In Situ;inhibitor;innovation;instrumentation;Integral Membrane Protein;Integration Host Factors;lipidomics;Lipids;Liposomes;mechanical properties;Membrane;Methodology;Mission;Modeling;Molecular;Molecular Conformation;molecular dynamics;Morphology;National Institute of Allergy and Infectious Disease;new therapeutic target;novel therapeutic intervention;Nuclear Import;Nuclear Pore;Nuclear Pore Complex;Pathway interactions;Process;protein complex;Protein Region;Proteins;Replication-Associated Process;Research Personnel;Resolution;Retrovirology;RNA;Sampling;Services;simulation;small molecule;structural biology;Structure;supercomputer;System;Techniques;Time;tool;trafficking;Validation;Viral;Virion;Virus;Virus Replication

PROJECT_TITLE: Computational Core


PI_NAMEs: ZHANG, PEIJUN  (contact)

PROJECT_TERMS: Area;Attention;Capsid;Cells;Classification;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Electron Microscopy;Environment;experience;flexibility;Fluorescence Microscopy;glycoprotein 41;HIV;HIV-1;Image;In Situ;Individual;Infection;inhibitor;Integration Host Factors;Ions;Label;light microscopy;Macromolecular Complexes;Methods;nanometer resolution;new technology;Nuclear Import;Nuclear Pore;Nuclear Pore Complex;nuclear pore complex protein 96;particle;Play;Process;protein complex;Proteins;Resolution;Sampling;Scanning Electron Microscopy;single molecule;small molecule inhibitor;software development;Software Tools;Structure;superresolution microscopy;Techniques;Technology;trafficking;ultra high resolution;Viral;Virion;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Cryo EM/ET Core


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Neurosciences;Physical Activity;Physical Rehabilitation;Precision Medicine;Rehabilitation;Stroke

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE  Personalizing stroke gait rehabilitation hinges on our understanding of how neural constrains limit an individual’s ability to coordinate many muscles and joints to achieve relatively few task level goals, such moving the whole-body stably, efficiently, and quickly. This project will characterize interindividual and inter-limb differences in whole-body dynamics and joint-level strategies for achieving desired whole body dynamics during treatment. Identifying characteristic relationships between joint and whole-body dynamics may explain diverse treatment responses and provide novel metrics to characterize stroke gait rehabilitation.

PI_NAMEs: ROSENBERG, MICHAEL CHARLES (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Address;Adult;Biofeedback;Biomechanics;career;Cerebral Palsy;Characteristics;Child;Classification;Clinical;Clinical Trials;Complement;Complex;Computational Technique;Data;Data Set;data-driven model;design;Exhibits;Experimental Designs;flexibility;Gait;Gait abnormality;gait rehabilitation;Gait speed;Goals;Hemiplegia;Impairment;improved;Individual;Individual Differences;Individuality;innovation;Joints;Lead;Limb structure;Literature;Methodology;model design;Modeling;Motion;Movement;Muscle;Nervous System;Nervous System Trauma;Network-based;neural;Neuromechanics;novel;Paresis;patient population;Pattern;personalized medicine;post stroke;Prediction of Response to Therapy;recurrent neural network;rehabilitation technology;Rehabilitation therapy;Research;response;Series;skills;Speed;Stroke;stroke survivor;Subgroup;Techniques;Testing;Time;Training;treadmill;treatment responders;treatment response;Visual;Walking;walking speed;Work

PROJECT_TITLE: Modulation of gait dynamics post-stroke


PROJECT_TERMS: biophysical properties;Capsid;Cell Nucleus;cell type;Communities;Complex;data acquisition;Data Analyses;design;Detection;Disease;Environment;Equipment;experimental study;Fluorine;Frequencies;Future;Goals;HIV;HIV-1;in vivo;inhibitor;innovation;insight;Institution;instrumentation;Integrase;Integrase Inhibitors;Integration Host Factors;Magic;magnetic field;Maps;Measurement;Measures;Methodology;Methods;Molecular Conformation;Nature;new technology;NMR Spectroscopy;Nuclear;Nuclear Import;Physiological;Positioning Attribute;protein structure;Proteins;Protocols documentation;Recombinant Proteins;Research;Research Personnel;Resolution;Resources;Savings;screening;Site;solid state;solid state nuclear magnetic resonance;Spin Labels;structural biology;Structure;Technology;Time;trafficking;Work

PROJECT_TITLE: NMR Core


PI_NAMEs: AIKEN, CHRISTOPHER R (contact)

PROJECT_TERMS: Amino Acids;Award;Binding Sites;Biological Assay;Capsid;CD4 Positive T Lymphocytes;Cell Culture Techniques;cell type;Cells;Chimeric Proteins;Chromatin;Code;Collaborations;Communities;Complement;Complex;CRISPR/Cas technology;crosslinking and immunoprecipitation sequencing;Data;deep sequencing;Defect;Development;Engineering;Ensure;experience;Experimental Designs;experimental study;Genes;genetic manipulation;Goals;Histones;HIV;HIV-1;Human;Human Resources;imaging study;In Vitro;Infection;integration site;interest;knock-down;Knock-in;Knock-out;knockout gene;Lentivirus Vector;live cell imaging;Maps;member;Morphology;Mutagenesis;mutant;Mutation;Mutation Analysis;novel;Nuclear;Nuclear Import;Nuclear Pore;particle;preference;protein complex;protein transport;Proteins;Recombinants;Research;Research Personnel;Resolution;Reverse Transcription;Services;Sheep;Site;small molecule inhibitor;Staging;Structure of choroid plexus;T-Lymphocyte;Testing;tool;trafficking;transcriptional coactivator p75;Transmission Electron Microscopy;Tubular formation;Validation;Viral;Viral Genome;Virion;virology;Virus;Work

PROJECT_TITLE: HIV Virology Core


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

PI_NAMEs: GANSER-PORNILLOS, BARBIE K. (contact)

PROJECT_TERMS: Binding;Binding Proteins;Binding Sites;Biochemical;Biochemistry;Biological Assay;Biological Metamorphosis;Capsid;CASP1 gene;Complement;Complex;Computational Technique;crosslinking and immunoprecipitation sequencing;Cryoelectron Microscopy;Cytoplasmic Tail;Data;design;Development;dimer;Disulfides;drug candidate;Drug resistance;Enzymes;experimental study;Generations;Genetic Polymorphism;genomic RNA;glycoprotein 41;Goals;HIV;HIV-1;HIV-1 integrase;imaging approach;improved;Individual;inhibitor;insight;Integrase;Integrase Inhibitors;Investigation;Knowledge;Magic;Mediating;Molecular;mutant;Mutation;novel;Nucleocapsid;particle;Pathway interactions;Peptide Hydrolases;Play;pol Gene Products;prevent;Process;Protein Inhibition;Proteins;Research Personnel;Resistance;Ribonucleoproteins;RNA;RNA-Directed DNA Polymerase;RNA-Protein Interaction;Role;Series;Site;solid state nuclear magnetic resonance;Structure;superresolution microscopy;Techniques;Testing;Variant;Viral;Viral Matrix Proteins;Viral Physiology;Viral Proteins;viral resistance;Virion;virology;Virus;Virus Replication;Visualization;Work

PROJECT_TITLE: Project 1. Maturation and Assembly


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PI_NAMEs: AMBROSE, ZANDREA  (contact)

PROJECT_TERMS: Amino Acid Substitution;Anti-Retroviral Agents;Binding;Biochemical;Biological Assay;Capsid;Capsid Proteins;CD4 Positive T Lymphocytes;Cell membrane;cell motility;Cell Nucleus;Cells;clinically relevant;cofactor;Complement;Complex;Cryoelectron Microscopy;Cyclophilin A;Cytoplasm;Data;Dependence;Development;DNA;dynactin;Dynein ATPase;Enzymes;Genome;Goals;Guanine Nucleotide Exchange Factors;HIV;HIV-1;Immune;Immune Evasion;Immunologic Factors;Infection;inhibitor;Integration Host Factors;integration site;Kinesin;Knowledge;live cell microscopy;Macrophage;Mediating;Methods;Microtubule-Associated Proteins;Microtubules;molecular dynamics;Motor;Mutation;Mutation Analysis;novel strategies;Nuclear;Nuclear Import;Nuclear Pore Complex;Nuclear Pore Complex Proteins;particle;Pattern;Process;protein transport;Proteins;recruit;Research;Research Personnel;Resolution;Reverse Transcription;RNA;spatiotemporal;Structure;superresolution imaging;T-Lymphocyte;Therapeutic;trafficking;Travel;Tubulin;Viral;Viral Genome;Viral Packaging;Viral Proteins;virology;Virus;Virus Diseases;X-Ray Crystallography

PROJECT_TITLE: Project 2. Immune evasion, trafficking, and nuclear import


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Multiple lines of evidence suggest the involvement of brain and peripheral innate and adaptive immunity in Alzheimer’s disease (AD); however, the mechanisms remain unknown. The proposed studies will perform multi-tissue (brain, meninges, choroid plexus and peripheral blood) single cell multiomics and spatial transcriptomics profiling of immune cells in AD and control cases. To gain additional mechanistic insights into the interaction among the adaptive and innate immunity, we will perform parallel studies in AD mouse models.

PI_NAMEs: HAROUTUNIAN, VAHRAM ;LEE, DONGHOON ;MCALPINE, CAMERON STUART;ROUSSOS, PANAGIOTIS  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;adaptive immunity;Affect;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Antigens;Astrocytes;Automobile Driving;B-Lymphocytes;Behavioral;Biological Response Modifiers;Blood - brain barrier anatomy;Brain;brain parenchyma;brain tissue;case control;CD8-Positive T-Lymphocytes;Cell Communication;Cell Surface Proteins;cell type;Cells;Central Nervous System;Cerebrospinal Fluid;Clinical;Clonal Expansion;Communication;Communities;cytokine;Data;Disease;Disease Progression;expectation;Fresh Tissue;Future;Gene Expression;Generations;Genetic Transcription;healthy aging;Human;Image;Immune;In Situ;Innate Immune Response;Innate Immune System;insight;Interleukins;Knock-out;Ligands;Location;Mediating;Meningeal;Meninges;Microglia;Modeling;mouse model;multiple omics;Mus;Natural Immunity;Nerve Degeneration;Neurobiology;novel;Pathogenesis;Pathologic;Patients;Pattern;Peripheral;peripheral blood;Phenotype;Production;programs;Publishing;receptor;Resolution;Resources;Role;Sampling;Source;Specificity;Specimen;Structure of choroid plexus;T-Lymphocyte;T-Lymphocyte Subsets;Taxonomy;Testing;Thinking;Tissue Banks;Tissues;transcriptomic profiling;transcriptomics;Work

PROJECT_TITLE: The adaptive-innate immune interactome across multiple tissues in Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Z(55)R]


PI_NAMEs: CHEREPANOV, PETER  (contact)

PROJECT_TERMS: Active Sites;Affinity;Architecture;ATAC-seq;Binding;Biochemical;Biological;Biological Assay;CD4 Positive T Lymphocytes;Cells;Chemicals;Chromatin;Chromosomes;Code;Color;Complex;Confocal Microscopy;Creativeness;CRISPR/Cas technology;Cryoelectron Microscopy;Data;deep sequencing;DNA;DNA Footprint;DNA Integration;Enzymes;Epigenetic Process;experimental study;Fluorescence;Fluorescence Microscopy;fluorophore;Genes;Genomic DNA;Glass;Goals;graphene;Histone H3;histone methylation;HIV;HIV-1;HIV-1 integrase;Homo;Human;In Vitro;Individual;inhibitor;insight;Integrase;Integrase Inhibitors;Integration Host Factors;integration site;Knock-in;Label;laser tweezer;lentiviral integration;Lentivirus;Maps;Mediating;Medicine;Microfluidics;Microscopy;Modeling;Modification;Molecular Weight;Monoclonal Antibodies;Mutagenesis;mutant;Mutation;nanobodies;novel;Nucleoproteins;Nucleosomes;Nucleotides;optic trap;optic tweezer;particle;Persons;Polynucleosome;Positioning Attribute;Preparation;Process;Property;Proteins;PWWP Domain;Reader;Reagent;Recombinant Proteins;Recombinants;Resolution;Reverse Transcription;Role;Sheep;single molecule;SIV;Slide;Specificity;Streptavidin;Structure;suicidal;T-Lymphocyte;Techniques;Testing;Therapeutic Intervention;Time;trafficking;transcriptional coactivator p75;Viral;viral DNA;Viral Reverse Transcription;Virus Diseases;Virus Integration;Visna-maedi virus;Work

PROJECT_TITLE: Project 3. Integration


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hematology;Infant Mortality;Liver Disease;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Severe neonatal jaundice can be fatal and is a leading cause of death among newborns in many developing countries. The blood tests needed to detect severe jaundice are expensive and invasive, but non-invasive options have low accuracy in dark-skinned newborns. We propose to develop and clinically test the ability of a novel, non-invasive mobile phone-integrated device to provide accurate, point-of-care detection of jaundice in dark-skinned newborns.

PI_NAMEs: BOWDEN, AUDREY KYNSELLA (contact)

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Acute;African;Agreement;Algorithms;Bilirubin;Birth;Blood;Blood specimen;Blood Tests;Blood Vessels;Cause of Death;Cellular Phone;Chest;Clinical;clinical decision-making;Clinical Research;clinically relevant;computerized data processing;Computers;cost;Darkness;Data;design;Detection;detector;Developing Countries;Devices;experience;Forehead;Frequencies;global health;Health;Health Insurance Portability and Accountability Act;Heel;Hemoglobin;Hospitals;Hour;Hyperbilirubinemia;Icterus;Imaging Techniques;in vivo;Infection;innovation;Kernicterus;Laboratories;liver function;low and middle-income countries;low income country;Measurement;Measures;Melanins;Methods;mHealth;Miniaturization;miniaturize;mobile application;Monitor;Morbidity - disease rate;mortality;Neonatal Jaundice;Neonatal Mortality;neonate;Neonatology;Newborn Infant;Nigeria;Noise;novel;Optical Coherence Tomography;Optics;Pain;Patients;Performance;peripheral blood vessel;Photography;Phototherapy;point of care;Point of Care Technology;point-of-care detection;portability;Resolution;screening;Serum;Signal Transduction;Skin;smartphone application;Spectrum Analysis;statistics;Structure;System;Teaching Hospitals;Technology;Testing;Time;Tissues;Transfusion;transmission process;Variant;Whole Blood;Work

PROJECT_TITLE: Smart-phone-integrated, non-invasive, depth-resolved optical spectroscopy for the detection of neonatal jaundice

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: EMERGENCY MEDICINE

PHR: PROJECT NARRATIVE The proposed research aims to reduce mental health disparities in the Latinx community by enlisting  promotoras, who are trusted community voices, to collaborate in designing and later to deliver a culturally  specific intervention to improve mental health services use. We will measure the impact of this intervention at  the community, interpersonal, and individual levels. Ultimately, our goal is to create a sustainable and scalable  model and culturally specific materials to decrease disparities in mental health services use within the Latinx  community as well as to create a template for conducting similar outreach in other underserved communities.

PI_NAMEs: KAYSEN, DEBRA L;NEWBERRY, JENNIFER A (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Accountability;Address;Caring;Characteristics;Chronic;Cluster randomized trial;Collaborations;Communities;community engagement;Community Health Education;community partners;Community Services;Community Surveys;community-level factor;Cross-Sectional Studies;cultural competence;Data;Data Collection;Data Sources;design;Disparity;disparity reduction;diverse data;Educational Curriculum;efficacy evaluation;empowerment;Expectancy;Fostering;Geographic Information Systems;Goals;Health;health care delivery;health care disparity;health disparity;health empowerment;health literacy;health service use;Health Services;Health Services Accessibility;help-seeking behavior;improved;Individual;innovation;insight;Intervention;Interview;Knowledge;Latinx;Latinx population;Lead;Learning;Legal Status;Maps;Measures;Mental disorders;Mental Health;mental health education;Mental Health Services;Methods;Mission;Modeling;National Institute of Mental Health;Outcome;outreach;Pathway Analysis;Pathway interactions;patient population;Patient Self-Report;Population;post intervention;Prevalence;prevent;Provider;Public Health;Research;Role;Self Efficacy;Services;Social Characteristics;social influence;Social Network;social stigma;Spanish;Structure;Survivors;Target Populations;Testing;Training;Trauma;trend;Trust;underserved community;Underserved Population;Violence;Voice;Work

PROJECT_TITLE: A Promotora-centric Community Collaborative to Improve Connections to Mental Health Services


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project narrative: The current proposal takes a critical direction by aiming to reveal the brain- wide principles underlying the development of mnemonic and executive functions of the mammalian brain. This development is conceived as the result of age- and experience- dependent maturation of network computations within the MEC and the mPFC and of neuronal ensemble coordination between these areas and the hippocampus (e.g., memory-guided decision making). The results of these studies promise to indicate new targets for preventive and therapeutic interventions in early-onset neuropsychiatric disorders.

PI_NAMEs: DRAGOI, GEORGE  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Adult;Age;Animals;Area;Brain;Chronic;cognitive function;Communication;critical developmental period;Decision Making;Dependence;Development;early onset;Electrophysiology (science);Ensure;entorhinal cortex;Environment;Episodic memory;executive function;experience;experimental study;Hippocampus;Investigation;Life;long term memory;mature animal;Medial;Memory;memory consolidation;memory encoding;neuron development;Neurons;neuropsychiatric disorder;novel;Pattern;postnatal;postnatal development;preventive intervention;Process;Rattus;Research;Rodent;Sampling;Sleep;spatial memory;Therapeutic Intervention;way finding

PROJECT_TITLE: Development and organization of brain-wide neuronal ensemble circuits underlying memory and decision making


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE Racial disparities in maternal health in Georgia are stark and in need of systematic review, analysis, and intervention. This study will combine a statewide assessment of racial disparities in adverse maternal health outcomes with an evaluation of Georgia’s Medicaid Inter-pregnancy Care Program and a randomized trial of a comprehensive postpartum care system in an urban safety-net hospital. By studying the complex array of individual, health care system, community, and societal level factors that culminate in women’s lack of access we will fill critical gaps in knowledge regarding policy and health system approaches for reducing disparities in maternal morbidity and mortality.

PI_NAMEs: ADAMS, ESTHER KATHLEEN;DUNLOP, ANNE LANG (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Adherence;Admission activity;adverse outcome;Affect;Birth;cardiometabolism;cardiovascular risk factor;care fragmentation;care outcomes;care systems;Caring;Case Management;Case Management Nurse;Case Manager;Cessation of life;Chronic;Clinical;Collaborations;Communities;Complex;Computerized Medical Record;Contraceptive methods;Data;Death Rate;design;Developed Countries;Diabetes Mellitus;disparities in morbidity;disparities in women;Disparity;disparity reduction;Enrollment;ethnic difference;ethnic disparity;Ethnic Origin;Ethnic Population;Evaluation;experience;Familiarity;Family Planning;Family Planning Programs;follow-up;Foundations;Future;Gestational Diabetes;Guidelines;Health;health care service utilization;Health Care Visit;health disparity;Health Personnel;Health Services;Health system;Healthcare;Healthcare Systems;high risk;High Risk Woman;hospital readmission;Hospitalization;Hospitals;Hypertension;Improve Access;improved;Individual;inner city;insight;Institution;Insurance;interdisciplinary approach;Intervention;Interview;Knowledge;Link;Live Birth;Location;Low income;Managed Care;Maternal Health;maternal morbidity;Maternal Mortality;Medicaid;Medical;Methods;Mind;Minority Women;Mothers;multidisciplinary;National Institute on Minority Health and Health Disparities;Not Hispanic or Latino;Obesity;Outcome;Outcome Assessment;Outcome Measure;outreach;Participant;patient oriented;Pharmaceutical Preparations;Policies;Politics;postpartum care;Postpartum Period;Postpartum Women;pragmatic randomized trial;Pregnancy;Pregnancy Complications;pregnancy hypertension;Pregnant Women;prenatal;Prenatal care;Prevalence;preventable death;Prevention strategy;Primary Care;Process Measure;programs;Provider;Race;racial difference;racial disparity;racial population;Randomized;randomized trial;Recommendation;Records;Research;Resources;Review Committee;Risk;Risk Factors;safety net;screening;Services;severe maternal morbidity;Site;social;Social support;standard care;standard of care;success;System;systematic review;Time;Translating;Uninsured;Variant;Very Low Birth Weight Infant;Visit;White Women;Woman;Work

PROJECT_TITLE: Minding the gap: a multidisciplinary approach to reducing maternal health disparities in Georgia


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Kidney Disease;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Alport syndrome, a genetic chronic kidney disease, damages the ultrafilter causing kidney failure. We study the molecular architecture and function of the collagen scaffolds that comprise the normal filter and which are damaged by this disease. The knowledge gained provides a framework to develop new forms of therapy.

PI_NAMEs: BUDKO, SERGEY PETROVICH;HUDSON, BILLY GERALD (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: Achievement;Address;Adult;Affect;Angiotensin-Converting Enzyme Inhibitors;Animal Model;appendage;Architecture;Binding Sites;Biological;Cells;Chronic Kidney Failure;Clinical;COL4A3 gene;Collagen;collagen scaffold;Collagen Type IV;Cysteine;Defect;Deposition;Development;Disease;End stage renal failure;enzyme replacement therapy;Foundations;Functional disorder;Genes;Genetic;genetic variant;Genetic Variation;glomerular basement membrane;glomerular filtration;glomerular function;Hematuria;Hereditary nephritis;improved;Individual;insight;Investigation;Kidney Failure;kindred;Knowledge;Lead;Link;loss of function;Microscopic;Molecular;Molecular Chaperones;Morphology;mouse model;Mus;novel therapeutic intervention;novel therapeutics;Outcome;Pathogenesis;Pathogenicity;Patients;pharmacologic;Precision therapeutics;Prognosis;Proteins;Receptor Cell;Residual state;scaffold;Site;small molecule;Structure;Testing;therapy development;Translating;Ultrafiltration;Variant

PROJECT_TITLE: Molecular Pathobiology of Alport Syndrome

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: NARRATIVE Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder with a high prevalence in the USA and is found to be tightly associated with the cellular toxic effects caused by excess input of lipids in the liver. The proposed studies will investigate the knowledge gap of the fate of the cell digestion-derived lipids, and how it relates to NAFLD progression. Identification of the transport and distribution of this part of lipids and the related molecular mechanisms will deepen the understanding to NAFLD pathology and promote strategy designs for NAFLD interventions.

PI_NAMEs: PU, JING  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Cell Physiology;Cells;Cellular Metabolic Process;Cytoprotection;design;Digestion;Disease Progression;extracellular;fatty acid metabolism;fatty acid transport;Genetic Screening;Hepatocyte;High Prevalence;Homeostasis;Human;Intervention;Intracellular Membranes;Knowledge;Lipid Mobilization;lipid transport;Lipids;Liver;Lysosomes;Mediating;Membrane;Metabolic Diseases;Molecular;mouse model;Names;non-alcoholic fatty liver disease;Nonesterified Fatty Acids;Normal Cell;novel;Organelles;Pathology;Physiological;Play;prevent;Prevention;Probability;Process;protein protein interaction;Proteins;Regulation;Role;Site;Source;Testing;Tissues;Toxic effect;Work;Yeasts

PROJECT_TITLE: Lysosome‐Lipid Droplet Interactions in Fatty Acid Metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: Harrison

ORG_NAME: SAPIENCE THERAPEUTICS, INC.

PHR: NARRATIVE A protein called -catenin regulates many cell functions related to cell replication, growth and death through interaction with a vast network of many other proteins. Attempts to disrupt -catenin activity therapeutically have failed to date because previous attempts could not selectively inhibit its cancerous activity while maintaining its normal, required functions. The interaction of -catenin with a protein called BCL9 is often the cause of breast and other cancers, and represents an ideal therapeutic target. We have developed a peptide to selectively block the interaction between -catenin and BCL9, which we now propose to advance through animal testing to bring to testing in humans.

PI_NAMEs: ROTOLO, JIM  (contact)

PROGRAM_OFFICER_NAME: FRANCA-KOH, JONATHAN C

PROJECT_TERMS: Ablation;Advanced Development;Adverse effects;Affinity;Amino Acid Substitution;Amino Acids;Animal Testing;antagonist;anti-tumor immune response;BCL9 gene;beta catenin;Binding;Biological Availability;Biological Markers;Breast;Breast Cancer Model;Breast Cancer Treatment;cancer therapy;Cancerous;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Cessation of life;chemotherapy;Clinical;clinical development;clinically relevant;cytotoxicity;Data;design;Development;Dose;Drug Targeting;enantiomer;experimental study;first-in-human;Genes;Genetic;Genetic Transcription;Growth;Guidelines;Human;immunogenicity;In Vitro;in vitro activity;in vivo;Infiltration;inhibitor;inhibitor therapy;intestinal epithelium;Intravenous infusion procedures;lead candidate;Lymphocyte;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Metastatic Neoplasm to Lymph Nodes;migration;Miniature Swine;Mus;nanomolar;neoplastic cell;Oncogenic;overexpression;participant enrollment;Pathway interactions;patient derived xenograft model;Patients;Penetration;Peptide Library;Peptides;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;pharmacologic;Pharmacology and Toxicology;Pharmacology Study;Phase;Phenotype;Prognosis;programmed cell death ligand 1;Proteins;Rattus;receptor;Recurrence;Research Design;safety study;Series;Signal Pathway;Signal Transduction;Small Business Innovation Research Grant;Solubility;Sprague-Dawley Rats;standard of care;Structure-Activity Relationship;success;Testing;Therapeutic;therapeutic candidate;therapeutic target;Tissues;Toxic effect;Toxicokinetics;Toxicology;Transactivation;Transcription Coactivator;triple-negative invasive breast carcinoma;tumor;Tumor Escape;tumor growth;Tumor Immunity;tumor initiation;tumor microenvironment;tumor progression;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;WNT Signaling Pathway;Xenograft procedure

PROJECT_TITLE: Development of a cell-penetrating beta-catenin antagonist peptide as a therapeutic candidate for Wnt-driven breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-R(12)B]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative Several dementias, including Alzheimer’s disease, include deteriorations in our ability to understand and remember where we are in space. A richer cellular and circuit-level understanding of how spatial navigation is achieved may inform novel therapeutic strategies for targeting these conditions, reducing the heavy burden they place on individuals and society.

PI_NAMEs: MAIMON, GABY  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TITLE: How Brains Build Navigational Variables and Use them to Guide Behavior


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative We identified endogenous IFN-Stimulated Gene 15 (ISG15) as a negative regulator of osteoclasts, whereas cell-secreted ISG15 mediates inflammatory osteolysis. The goal of the project is to elucidate the respective mechanisms and develop strategies to combat osteolysis using modified forms of ISG15 as a therapy.

PI_NAMEs: ABU-AMER, YOUSEF  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Ablation;Acceleration;Autophagocytosis;Binding;bone loss;Bone remodeling;Bone Resorption;Calibration;Cell secretion;Cells;combat;cytokine;Data;Enzymes;Event;Extracellular Space;Family;Feedback;Genes;Goals;Homeostasis;In Vitro;in vivo;Inflammatory;Injections;Interferon alpha;Interferon Type I;Interferon-beta;Interferons;Knockout Mice;Ligands;Ligase;Mediating;member;Metabolic;Modality;Molecular;Mus;Myelogenous;Myeloid Cells;neutralizing antibody;NF-kappa B;novel;osteoclast progenitor;osteoclastogenesis;Osteoclasts;Osteolysis;Osteopenia;overexpression;paracrine;Pathologic;Pathway interactions;Physiological;Post-Translational Protein Processing;Process;Production;Proteins;Proteomics;RANK protein;receptor;Receptor Signaling;Regulation;response;Role;Secretory Vesicles;Serum;Signal Pathway;Signal Transduction;Signaling Protein;Site;small molecule;stem cell differentiation;Stimulator of Interferon Genes;Testing;TNF gene;Tumor necrosis factor receptor 11b;Ubiquitin;Virus

PROJECT_TITLE: Regulation of Osteoclastogenesis and Inflammatory Osteolysis

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Genetics;Kidney Disease

ORG_CITY: SIOUX FALLS

ORG_NAME: SANFORD RESEARCH/USD

ORG_STATE: SD

PHR: PROJECT NARRATIVE: Mutations in MYH9 that encodes for Nonmuscle Myosin IIA (NM2A), an actin associated motor protein, have been associated with kidney disease in humans, but the mechanisms by which MYH9 mutations cause kidney disease is unclear. Previous work focused on podocyte actin cytoskeleton in the Glomerulus. Our recent work established a novel function for Myh9&10 proteins in cargo transport in the thick ascending limb (TAL) epithelium, and loss of this function in mice resulted in rapidly progressing kidney disease. We propose to investigate the role of Myh9&10 in the TAL cargo transport system in the kidney. We will also test if combined loss of Myh9 protein in podocyte as well as tubular epithelium will lead to exacerbated disease due to synergistic functional loss in both cell types. Our work will directly address the loss of distinct functions of Myh9 in two different cell types within the kidney, reasonably modeling a severe form of MYH9-RD with complete loss of function.

PI_NAMEs: CHANDRASEKAR, INDRA  (contact)

PROJECT_TERMS: Actins;Address;Adult;apical membrane;Architecture;autosomal dominant mutation;Biochemical;Biological Models;Cell Culture System;Cell model;Cell Physiology;cell type;Cells;Chronic Kidney Failure;Code;comparative;Complex;conditional knockout;Cytoskeleton;Defect;Diet;dietary salt;Disease;disease phenotype;Dissection;Endoplasmic Reticulum;endoplasmic reticulum stress;Epithelial Cells;Epithelium;Epstein's syndrome;Exhibits;experimental study;Functional disorder;functional loss;Genes;glomerular function;glomerulosclerosis;high salt diet;Human;human disease;In Vitro;in vivo;in vivo Model;Individual;Injury;insight;Kidney;kidney cell;Kidney Diseases;Knockout Mice;Limb structure;loss of function;Mediating;Membrane;Membrane Proteins;Modeling;Molecular;Motor;mouse model;Mus;Mutation;Myosin Type II;non-muscle myosin;Nonmuscle Myosin Type IIA;novel;Organelles;paralogous gene;Pathologic;Pathology;Pathway interactions;Patients;Physiological;Play;podocyte;Point Mutation;Protein Isoforms;Proteins;Proteinuria;renal epithelium;Renal tubule structure;Research;response;Role;Severity of illness;sex;Sex Differences;Site;Structure;superresolution imaging;symporter;System;Testing;Thick;trafficking;Tubular formation;UMOD gene;Up-Regulation;Validation;Variant;Work

PROJECT_TITLE: Uncovering cargo and cell type specific molecular mechanisms of renal tubular epithelial transport

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Pediatric;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: IOWA CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on identifying shared experiences, opinions, advice, (mis)information, and persistent delivery features of those messages in tobacco product culture on social media, a key socio-ecological feature of the environment of adolescent and young adult (AYA) tobacco use. With this information, there is potential for significant improvement in responsiveness of research and practice to current AYA needs and authenticity of social media interventions for AYA. The project is relevant to NIDA’s mission because it will advance science on the social ecological environment and social mechanisms of nicotine addiction among adolescents and young adults.

PI_NAMEs: WATKINS, SHANNON LEA (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: addiction;Address;Adolescent and Young Adult;Affect;Algorithms;Behavior;Communication;communication theory;community based participatory research;community engaged approach;Data Collection;Dimensions;e-cigarette cessation;Electronic cigarette;electronic cigarette use;Environment;experience;Exposure to;Generations;Goals;Health behavior;health communication;improved;Industry;innovation;insight;Intervention;Investigation;Knowledge;Life;Longitudinal, observational study;Media Intervention;Methods;Misinformation;Mission;Modeling;National Institute of Drug Abuse;Nature;Nicotine Dependence;Observational Study;Outcome;Perception;Persons;Positioning Attribute;Primary Prevention;Process;programs;Public Health;public health intervention;Published Comment;Research;Research Design;Research Personnel;Risk Behaviors;Science;Shapes;Site;social;social media;substance use;Target Populations;Techniques;Teenagers;TikTok;Time;Tobacco;tobacco products;Tobacco use;Training;Work;young adult;Youth

PROJECT_TITLE: Social media as a social mechanism of non-cigarette tobacco use: Engaging young adults to examine tobacco culture online

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Biotechnology;Genetics;Kidney Disease

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative The renin-angiotensin system (RAS) plays a key role in the control of electrolyte and fluid homeostasis and blood pressure and inappropriate activation of this system leads to hypertension as well as inflammatory diseases in multiple organs. The current proposal aiming at defining PRR-24 as a new regulator of renin activity will offer new insight into the mechanism of action of the RAS in renal control of fluid homeostasis and blood pressure.

PI_NAMEs: YANG, TIANXIN  (contact)

PROJECT_TERMS: 5' Untranslated Regions;Ablation;Affect;Amino Acids;Antibodies;aquaporin-2;Binding;Blood Plasma Volume;Blood Pressure;Cell Nucleus;cis acting element;Cloning;Complementary DNA;Custom;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cytosol;Disease;Distal;Ductal Epithelial Cell;Electrolytes;Elements;Equilibrium;Event;Exons;Experimental Water Deprivation;Fluid Balance;Genetic Transcription;Hypertension;Hypotension;Inactive Renin;Inflammatory;Initiator Codon;insight;Introns;Investigation;Kidney;kidney medulla;Maps;Mediating;member;mRNA Expression;Mus;Mutagenesis;N-terminal;Nephrons;novel;Organ;Phosphorylation;Play;promoter;protein expression;Protein Isoforms;Proteins;Rattus;receptor;Regulation;Renin;Renin-Angiotensin System;response;Serine;Signal Induction;Signal Pathway;Signal Transduction;Site;System;Testing;Threonine;Tissues;trafficking;Urine;vasopressin resistant diabetes insipidus;Vasopressins;Water

PROJECT_TITLE: Cloning and characterization of PRR24 as a specific renin receptor critically involved in vasopressin signaling in the kidney


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;HIV/AIDS;Infectious Diseases;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE  This project will assemble the largest ever cohorts of persons with and without HIV infection who will be classified according to the presence of moderate-to-severe hepatic steatosis based on the application of artificial intelligence methods to clinically obtained noncontrast abdominal computed tomography (CT) scans. The proposed research will contribute to fundamental knowledge on the factors associated with hepatic steatosis and risk of liver complications associated with steatosis among persons with HIV and assess how these differ from those without HIV infection. The results of these studies will inform interventions to prevent or mitigate the development of hepatic steatosis among persons with HIV, which will help to lower the risk of liver complications and prolong survival in this population.

PI_NAMEs: TORGERSEN, JESSIE  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: abdominal CT;Address;Aging;Alcohol abuse;Alcohol consumption;Algorithms;antiretroviral therapy;Artificial Intelligence;artificial intelligence method;attenuation;Bioinformatics;Biometry;Cardiovascular system;Caring;CD4 Lymphocyte Count;Cells;Cirrhosis;Classification;Clinical;clinical care;co-infection;cohort;Cohort Studies;Computed Tomography Scanners;Computer Assisted;Computerized Medical Record;Data;deep learning;deep learning algorithm;Development;Diabetes Mellitus;Diagnosis;Dyslipidemias;elastography;Electronic Health Record;Epidemiology;Evaluation;Fatty Liver;follow-up;Future;General Population;Hepatic;Hepatocyte;Hepatology;HIV;HIV Infections;Hypertension;Image;Informatics;interest;Intervention;Knowledge;large datasets;Liver;liver biopsy;Liver diseases;liver inflammation;liver transplantation;Magnetic Resonance Imaging;Manuals;Measurement;Mediating;Medicine;Mentors;Mentorship;Metabolic dysfunction;Methodology;Methods;Morbidity - disease rate;mortality;multidisciplinary;novel;Obesity;obesogenic;Outcome;Outcome Study;Pathway interactions;Patients;Persons;Population;prevent;preventive intervention;Primary carcinoma of the liver cells;Prospective, cohort study;radiological imaging;radiologist;repository;Research;Research Personnel;Resources;Risk;Risk Factors;Risk Reduction;Sample Size;Sampling;Scanning;Science;screening;Selection Bias;Selection for Treatments;Severities;Surrogate Markers;Time;tool;Training;Triglycerides;United States;Veterans;Veterans Health Administration;Viral;Viral hepatitis;Viremia;Work;X-Ray Computed Tomography

PROJECT_TITLE: Use of Deep Learning Algorithms to Enable Evaluation of the Determinants and Outcomes of Hepatic Steatosis, by HIV Status

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK(M1)-1-C]


NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Narrative In the central nervous system, the activation of NMDA (N-methyl-D glutamate) receptors produces electrical currents that are essential for brain functions such as cognition, learning, and memory. Excess electrical currents cause cellular loss in stroke, brain and spinal cord injuries, and age-related diseases such as Alzheimer’s and Parkinson’s. In this project we will study how the internal parts of the receptor move during activation and how prospective drugs or clinically identified mutations alter these motions, to gain the basic knowledge that will enable the design of more effective therapeutic approaches for the many neurological conditions involving NMDA receptors.

PI_NAMEs: POPESCU, GABRIELA K (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Affect;age related;age-related disease;Alzheimer's Disease;atomic interactions;Brain;Calcium;causal variant;Central Nervous System;Chronic;Clinical;Cognition;Conscious;desensitization;design;Diagnosis;Disease;Genetic;genetic variant;Grain;Kinetics;Knowledge;Learning;Measurement;Mediating;Memory;Modeling;Molecular;Molecular Conformation;molecular dynamics;Motion;Mutation;N-Methyl-D-Aspartate Receptors;N-methyl-D-glutamate;N-Methylaspartate;Neurologic;Neurons;neuropsychiatric disorder;Output;Parkinson Disease;Pathology;Patients;Pattern;Pharmaceutical Preparations;Physiology;programs;prospective;Reaction;receptor;Receptor Activation;release of sequestered calcium ion into cytoplasm;Research;small molecule;spinal cord and brain injury;Stroke;Structure;Synapses;Testing;Therapeutic;therapeutic target;therapeutically effective;Thermodynamics;transmission process;Variant

PROJECT_TITLE: Molecular Physiology of NMDA Receptors


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: TUNIS

ORG_COUNTRY: TUNISIA

ORG_FIPS: TS

ORG_NAME: INSTITUT PASTEUR DE TUNIS

PHR: PROJECT NARRATIVE Tuberculous lymphadenitis (TBL), the most frequent extrapulmonary form of TB, is a serious health problem in Tunisia and throughout the developing world. Here, we propose to integrate single cell RNA-sequencing (scRNA-seq) and spatial-seq to analyze the cellular and molecular architecture of granulomas in TBL to understand host defense mechanisms to control the infection. As such, our studies of the specific immune biosignatures in TBL will expand our understanding of its immunopathogenesis, leading to improved diagnostic and therapeutic approaches.

PI_NAMEs: BENABDESSALEM, CHAOUKI  (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Acute;Affect;anti-microbial peptide;Antigens;antimicrobial;Architecture;Bacillus;Bacteria;Biological Markers;biomarker identification;Biopsy;biosignature;cell type;Chronic;Chronic Disease;Clinical;clinical care;Collaborations;Collection;cytokine;Cytotoxic T-Lymphocytes;Data;data integration;Diagnosis;Diagnostic;Disease;Ensure;Etiology;Gene Expression;Genes;Granuloma;granulysin;Health;Healthcare Systems;Histologic;Host Defense;Host Defense Mechanism;Human;Immune;Immune response;Immunocompromised Host;Immunologic Markers;improved;Individual;Infection;Infection Control;Inflammation;Inflammatory Response;insight;Interferons;Invaded;Leprosy;Ligands;Location;Lung;Lymph Node Tuberculosis;lymph nodes;Lymphocyte;Macrophage;Macrophage Activation;Maps;Measures;Mediator;microbicide;Microscopy;Modality;Molecular;molecular marker;mycobacterial;Mycobacterium bovis;Mycobacterium Infections;Mycobacterium tuberculosis;Organ;pathogen;Pathologic;Pathway interactions;Patient Care;Patients;peripheral blood;Pulmonary Tuberculosis;Pyrazinamide;radiological imaging;Research Training;Resistance;response;Scientist;single-cell RNA sequencing;Site;Spatial Distribution;Specimen;T cell response;T-Lymphocyte;technology training;Technology Transfer;Testing;Therapeutic;Tissues;transcriptomics;Tuberculosis;tuberculosis granuloma;Tunisia

PROJECT_TITLE: Cellular and molecular architecture of granulomas in human tuberculous lymphadenitis

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Transcription factors (TFs) mediate long range chromatin interactions to regulate specific gene expression; disruption of this process could lead to human diseases. The proposed research aims to develop a novel method for robust mapping of TF-mediated chromatin interactions which will help study the mechanisms of transcription regulation in physiological functions and pathological diseases.

PI_NAMEs: CHEN, LIN  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: 3-Dimensional;Adopted;Alkynes;Antibodies;Azides;base;Binding;Binding Sites;biochip;Bioinformatics;Biological Models;Biotin;Biotinylation;Cell Line;Cells;Chemistry;ChIP-seq;Chromatin;chromatin immunoprecipitation;Chromatin Interaction Analysis by Paired-End Tag Sequencing;cofactor;Communities;Complex;Computer Analysis;Data;design;differential expression;Disease;Distal;DNA;DNA Binding;DNA Ligation;DNA Modification Process;Epigenetic Process;experimental study;Feedback;FOXP3 gene;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Genome;Genome Mappings;genome-wide;genome-wide analysis;genomic tools;Hi-C;histone modification;Histones;human disease;Hybridomas;Immunoprecipitation;improved;In Situ;In Vitro;in vivo;interest;Joints;Knock-in;Label;Ligase;Ligation;Link;Locus Control Region;Maps;Mediating;Methods;model organism;Modification;Mutation;Names;novel;Nucleotides;Open Reading Frames;Pathologic;Physiological;Process;promoter;Proteins;Protocols documentation;Publishing;Reaction;Regulator Genes;Regulatory Element;Regulatory T-Lymphocyte;Reproducibility;Research;Resources;restriction enzyme;Role;Running;Series;Signal Transduction;Streptavidin;success;T-Lymphocyte;Techniques;Technology;Testing;three dimensional structure;tool;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;Transgenic Model;Untranslated RNA;Work

PROJECT_TITLE: Developing a robust method for analyzing transcription factor mediated chromatin interactions

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cardiovascular;Pediatric

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE This integrated pediatric research program will train physicians, surgeons, and basic scientists to perform collaborative basic, translational, and clinical research that will impact the care of infants and children with heart and lung diseases.

PI_NAMEs: BACKES, CARL ;GARG, VIDU  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Childhood;Pulmonary Heart Disease;Research Training;Training Programs

PROJECT_TITLE: Integrative Research Training Program in Pediatric Cardiopulmonary Disease

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Disability Research;Genetics;Neurodegenerative;Neurosciences;Rehabilitation;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: HERSHEY

ORG_DEPT: NEUROSURGERY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE Post-stroke cognitive impairment (PSCI) is a major sequela of stroke in both young and old stroke patients, with no FDA approved treatment. In this application, we propose to identify DKK3 as novel therapeutic target for the treatment of cognitive impairment induced by ischemic stroke. The proposed studies may reveal previously unappreciated mechanisms underlying PSCI and provide a novel therapeutic approach to improve cognitive outcomes following stroke.

PI_NAMEs: LI, GUOHONG  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;acute stroke;AD transgenic mice;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;beta amyloid pathology;Brain;Brain Injuries;Brain Ischemia;brain tissue;Clinical Research;Cognitive;Cognitive deficits;cognitive function;cognitive recovery;Data;Deposition;Down-Regulation;Drug Delivery Systems;Early treatment;efficacy evaluation;endoplasmic reticulum stress;experience;experimental study;FDA approved;gain of function;Gene Expression;hippocampal pyramidal neuron;Hippocampus;Hour;Human;Impaired cognition;Impairment;improved;Infarction;inhibitor;Injury;Intranasal Administration;Intravenous;intravenous administration;Ischemic Brain Injury;Ischemic Stroke;Knockout Mice;Link;Long term disability;loss of function;MicroRNAs;Middle Cerebral Artery Occlusion;Molecular Target;mouse model;Mus;Neurologic;Neurologic Deficit;Neurons;neuropathology;new therapeutic target;novel;novel therapeutic intervention;old mice;Outcome;Pathology;Patients;Phase;Play;post stroke;post stroke cognitive impairment;post stroke dementia;Proteins;Quality of life;Recombinants;reconstitution;Recovery;Regulation;Regulator Genes;Reperfusion Therapy;Role;Secondary to;Serum;Small Interfering RNA;Stroke;stroke cognitive outcome;stroke model;stroke patient;stroke survivor;Synaptic plasticity;Testing;Therapeutic;Therapeutic Effect;therapeutic target;thrombolysis;Time;Tissues;Untranslated Regions;Wild Type Mouse;young adult

PROJECT_TITLE: A New Molecular Target to Enhance Poststroke Cognitive Recovery

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Microbiome;Neurosciences;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Maternal obesity and consumption of high calorie diets continue to be public health concerns as the perinatal environment provides support that is critical to the proper development and health of offspring. Preliminary data suggests that maternal high fat (HF) diet during development is associated with changes in meal patterning suggesting impaired post-ingestive feedback along the gut-brain axis that may be a result of with microbiota dysbiosis. The current proposal will investigate how perinatal HF diet and dysbiosis alters gut-brain axis development and vagally- mediated controls of feeding in HF offspring and leads to increased susceptibility to obesity and other metabolic disorders.

PI_NAMEs: TAMASHIRO, KELLIE L. K. (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Adult;Affect;Afferent Neurons;Behavior;Birth;Brain;Calcium;Calories;Cell Count;Cell Physiology;Child;Cholecystokinin;combinatorial;Communication;comorbidity;Consumption;Coronary Arteriosclerosis;critical period;Data;Development;Diet;diet-induced obesity;dysbiosis;early life exposure;Eating;Energy consumption;Enteroendocrine Cell;Environment;Epidemic;experimental study;Exposure to;Fat-Restricted Diet;Fatty acid glycerol esters;Feedback;feeding;Fetus;Future;genome wide association study;genomic locus;Germ-Free;gut dysbiosis;gut microbiota;gut-brain axis;Health;High Fat Diet;Homeostasis;Hormones;Hyperphagia;Hypertension;Image;Impairment;improved;Individual;Inflammation;Inflammatory;innovation;Interdisciplinary Study;Intervention;intestinal crypt;Intestinal permeability;Intestines;Lactation;Leaky Gut;Life;Malignant Neoplasms;maternal obesity;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic syndrome;Methods;microbiota;microbiota composition;Modeling;mother nutrition;Mothers;neonate;neural;Neurobiology;Neurons;neurotransmission;Non-Insulin-Dependent Diabetes Mellitus;normal microbiota;Nutrient;nutrition;Obesity;obesity in children;offspring;Outcome;Overweight;Pattern;Perinatal;perinatal environment;Perinatal Exposure;Peripheral;Phenotype;physical inactivity;postnatal;postnatal period;prebiotics;Predisposition;Pregnancy;Prevalence;prevent;Public Health;Rattus;Regulation;Resistance;response;Risk;Role;Satiation;Sensory;Signal Transduction;skills;Starch;Stimulus;Structure;systemic inflammatory response;Testing;therapy development;Time;Tracer;translation to humans;Vagus nerve structure;Virus;Weaning;Weight Gain

PROJECT_TITLE: Maternal diet and programming of offspring gut-brain axis

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]