NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Physical Rehabilitation;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Urologic Diseases;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Our interdisciplinary team of urogynecologists, clinical psychologists, physical therapists, epidemiologists, and experts in community-health and disparities submit this application, which is an ideal response to NIDDK’s RFA for Stimulation Urologic Interdisciplinary Team Opportunity Research (SUITOR). This proposal will lead to improved treatment of urinary incontinence and lower urinary tract symptoms (common, embarrassing, costly and under-treated disorders) in minority women who face significant barriers to care and have been systematically left behind with respect to evidence-based non-surgical approaches to urinary incontinence. Given barriers to accessing physical therapy and the behavioral and mental health impacts of urinary incontinence, this project will evaluate the feasibility and efficacy of a culturally-specific, home- based, online, community health-worker supported, conservative intervention for urinary incontinence. We hypothesize that improvement in urinary incontinence symptoms of women receiving SUPPORT therapy will be non-inferior to those receiving the gold-standard treatment of in-person physical therapy and will lead to improved mental health.

PI_NAMEs: GRIFFITH, JAMES WILLIAM;KENTON, KIMBERLY SUE (contact);SIMON, MELISSA A.

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: Adherence;Anxiety;barrier to care;Behavior Therapy;Behavioral;behavioral health;Bladder Control;Body Weight decreased;care seeking;Chicago;Client satisfaction;Clinical;Cognitive Therapy;Communication;Communities;community based treatment;Community Health;Community Health Aides;copayment;cost;Data;Diet Modification;Disease;Disparity;disparity reduction;Educational Curriculum;efficacy evaluation;efficacy study;efficacy testing;efficacy trial;Epidemiologist;evidence base;feasibility testing;feasibility trial;Funding;Future;handbook;health literacy;Health Services Accessibility;healthcare burden;Home;Hospitals;Human;human centered design;improved;Incontinence;incontinence symptom;innovation;Insurance Coverage;Intervention;Interview;Knowledge;Lead;Left;lifetime risk;Low income;lower urinary tract symptoms;Manipulative Therapies;Measures;Mediating;Medicaid;Medicare;Mental Depression;Mental Health;micturition urgency;Minority;Minority Health Research;Minority Women;National Institute of Diabetes and Digestive and Kidney Diseases;Observational Study;Operative Surgical Procedures;Outcome;Participant;Patient-Focused Outcomes;Patients;Pelvic floor structure;Persons;Physical Exercise;physical therapist;Physical therapy;Physical therapy exercises;Population Study;Post-Traumatic Stress Disorders;Private Practice;Process;programs;prospective;Psychologist;Psychology;Quality of life;Questionnaires;Recommendation;Reporting;Research;Research Design;Research Personnel;response;Sampling;Self Administration;Self Direction;Self Management;sexual trauma;Spanish/English;standard care;Symptoms;Therapeutic Intervention;Time;Training;Travel;Treatment Efficacy;Treatment Protocols;Urinary Incontinence;urologic;Urology;Woman;Writing

PROJECT_TITLE: REDUCING DISPARITIES IN URINARY CONTROL SYMPTOMS FOR MINORITY WOMEN

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: TALLAHASSEE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER BASIC SCIENCES

ORG_FIPS: US

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative The goal of this project is to understand how cells build a molecular “recycling center” called the proteasome. Alterations to the assembly of the proteasome cause or exacerbate many human diseases, including some cancers and many neurodegenerative disorders. Understanding how proteasomes are assembled will help us to design new treatments for these diseases that work by restoring normal protein recycling.

PI_NAMEs: SUO, ZUCAI ;TOMKO, ROBERT JOSEPH (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: 26S proteasome;Affinity;ATP phosphohydrolase;ATP-Dependent Proteases;base;Binding;Biogenesis;Biological Assay;Biological Process;Biology;Biophysics;Cells;chemical genetics;Chemicals;Collection;Complex;design;Development;Dimensions;Disease;Dissociation;Docking;Ensure;Environment;Enzyme Kinetics;Exogenous Factors;experimental study;flexibility;Fluorescence;Genetic;genetic approach;Goals;Human;human disease;Impairment;In Vitro;in vivo;Individual;interest;Investigation;kinetic model;Kinetics;Knowledge;Ligands;Literature;macromolecular assembly;Malignant Neoplasms;Measurement;Measures;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;Monitor;multicatalytic endopeptidase complex;mutant;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;novel therapeutic intervention;novel therapeutics;Nucleosome Core Particle;Outcome Study;particle;Pathologic;Pathway interactions;Physiological;polypeptide;Proteasome Binding;protein degradation;Proteins;Recycling;response;Route;single molecule;Site;Spectrum Analysis;Speed;Stimulus;stoichiometry;Stress;targeted treatment;Testing;Thinking;Time;tool;Work;Yeasts

PROJECT_TITLE: Investigation of the proteasome assembly landscape

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Physical Rehabilitation;Prevention;Primary Health Care;Rehabilitation;Rural Health;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Chronic pain is at the heart of the opioid epidemic and back pain is the most common condition leading to chronic pain. Improving back pain management and reducing disparities are important considerations in reducing the opioid crisis and improving the lives of impacted individuals. The goal of this project to identify effective strategies for providing nonpharmacologic alternatives to opioid pain management for patients with back pain in low income and rural communities using telehealth solutions.

PI_NAMEs: FRITZ, JULIE M (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;Area;Back Pain;Behavioral;Belief;care seeking;Caring;Characteristics;Chronic;chronic back pain;chronic pain;chronic pain patient;Clinic;Clinical Practice Guideline;Clinical Trials;Cognitive;Communities;community organizations;compare effectiveness;COVID-19 pandemic;Data;Data Analyses;Data Collection;design;Diagnosis;disparity reduction;Education;effectiveness evaluation;effectiveness outcome;Electronics;evidence base;evidence based guidelines;Exercise;Face;federal poverty level;Federally Qualified Health Center;frontier;Future;Gender;Goals;Health;health care availability;health care settings;Health Resources;Health system;Healthcare Systems;Heart;hybrid type 1 design;implementation evaluation;implementation outcomes;improved;Individual;innovation;Intervention;Low income;Manuals;Methods;Neighborhood Health Center;Nonpharmacologic Therapy;Opioid;opioid abuse;opioid epidemic;opioid misuse;opioid use;opioid user;Outcome;Outcome Study;Pain;Pain interference;Pain management;pain outcome;pain reduction;Patient Care;patient subsets;Patients;Persons;Phase;Phenotype;Physical therapy;Play;poor communities;Poverty;prescription opioid;Prevalence;prevent;Primary Care;primary care clinic;primary care provider;primary health center;primary outcome;Procedures;programs;Protocols documentation;Provider;randomized, clinical trials;Recommendation;Research;Resources;Risk Factors;Role;Rural;Rural Community;rurality;safety net;secondary outcome;Self Management;Services;Site;Societies;Specific qualifier value;teleconsultation;telehealth;Telephone;Testing;Training;treatment strategy;Utah;Veterans;Work

PROJECT_TITLE: Nonpharmacologic Pain Management in FQHC primary care clinics


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Rural Health

ORG_CITY: KNOXVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: This project is relevant to the mission of the National Heart, Lung, and Blood Institute because it will drive cardiac modeling and simulation into clinical applications, promote data-driven and simulation-guided surgical planning, and develop an interdisciplinary workforce who possesses both computational skills and medical insights. The success of this project will make a lasting impact on our society and bring a heart-healthy future.

PI_NAMEs: YANG, HUI ;YAO, BING  (contact)

PROGRAM_OFFICER_NAME: LUO, JAMES

PROJECT_TERMS: Ablation;Algorithms;Arrhythmia;Artificial Intelligence enhanced;artificial intelligence model;Atrial Fibrillation;Automobile Driving;base;Black Box;Cardiac;Cardiac ablation;Cardiac Surgery procedures;Cardiology;Catheters;Clinical;clinical application;clinical practice;Computer Models;Computer Simulation;coping;Coupled;Data;data streams;data-driven model;Decision Making;deep learning;design;Developing Countries;Diagnosis;Disease;Effectiveness;Elderly;Electrophysiology (science);Environment;Evaluation;experimental study;Family;fighting;Formulation;Foundations;frontier;Future;Goals;graph neural network;Health;health care disparity;Health Professional;Healthcare Systems;Heart;Heart Diseases;Human;improved;information processing;innovation;insight;Institutional Review Boards;Investments;Knowledge;Learning;Location;Machine Learning;Maps;Medical;Medical Students;Methodology;Mission;Modeling;models and simulation;Modernization;Monitor;multiple data sources;National Heart, Lung, and Blood Institute;network models;novel;novel strategies;open source;operation;Operative Surgical Procedures;Pathway interactions;Patients;Performance;Personal Satisfaction;Physics;Physiological;Policies;Population;Postoperative Period;Procedures;Process;Protocols documentation;Publishing;Research;response;rural area;sensor;Signal Transduction;simulation;skills;Societies;Solid;Source;success;surgery outcome;Surgical incisions;Technology;Time;tool;Training;transfer learning;Translating;Trees;Uncertainty;Variant;virtual

PROJECT_TITLE: SCH: Simulation Optimization of Cardiac Surgical Planning


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Body schema, i.e the body’s configurations and positions in 3D space, is critical for self- awareness and for motor control. Yet how the brain generates and updates such representation remain largely unknown. This research will not only solve this fundamental neuroscience mystery, but also provide insights into body schema representation deficits observed in many neurological diseases.

PI_NAMEs: WANG, FAN  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: 3-Dimensional;Algorithms;Area;awake;Awareness;Back;base;Behavior;Body part;body position;Brain;Cells;Computer Analysis;Conscious;Culicidae;Data;Esthesia;Hand;Human;Individual;insight;Knowledge;Mammals;model of autism spectrum disorder;motor control;mouse model;multi-electrode arrays;Mus;Neck;Nervous System Disorder;neural;neural circuit;Neurobiology;neuromechanism;Neurosciences;Nose;Output;Positioning Attribute;presynaptic;Process;Research;Self Perception;Subconscious;Testing;Touch sensation;Update

PROJECT_TITLE: Unraveling the Neural Bases of Body Schema


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Prevention;Rehabilitation

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE  Older people with lower extremity peripheral artery disease (PAD) have greater walking impairment and faster functional decline than those without PAD. Yet few therapies have been identified that improve disability in people with PAD. This randomized clinical trial will determine whether beetroot juice, which increases nitric oxide in lower extremity arteries and skeletal muscle, significantly improves walking impairment and/or prevents walking decline in older people with PAD, compared to placebo.

PI_NAMEs: MCDERMOTT, MARY MCGRAE (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: actigraphy;Acute;angiogenesis;arterial spin labeling;Arteries;Biogenesis;Biological;Biopsy;Blood capillaries;brachial artery;Cell Nucleus;Characteristics;Chronic;Clinical Trials;Consumption;density;disability;Disabled Persons;Dose;Double-Blind Method;Environment;Fiber;follow-up;functional decline;Functional impairment;Gait abnormality;Gastrocnemius Muscle;Health;Hour;Hypoxia;improved;Ingestion;inter-individual variation;Ischemia;ischemic injury;Juice;Lower Extremity;Magnetic Resonance Imaging;Measures;Mediating;Medical;Metabolic;Mitochondria;mitochondrial dysfunction;Muscle;Muscle Mitochondria;Muscle satellite cell;Natural regeneration;Nitrates;Nitric Oxide;Nitrites;NOS3 gene;Older Population;Oral;Outcome;Oxidative Stress;Oxygen Consumption;Participant;Pathway interactions;Performance;Perfusion;Peripheral arterial disease;Persons;Physical activity;Physical Performance;Placebos;Plasma;preclinical study;prevent;primary outcome;Quality of life;Questionnaires;Randomized;randomized trial;randomized, clinical trials;repaired;Reperfusion Injury;Research Personnel;Skeletal Muscle;Source;Spirometry;Walking;walking performance;Work

PROJECT_TITLE: BEET root juice to reverse functional impairment in PAD: The BEET PAD Trial

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ORG_CITY: BIRMINGHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Despite the emergence of new antiepileptic drug options, there is a consistent proportion of epilepsy patients that remain drug-resistant. This proposal takes an innovative approach by studying the role of the gut microbiota and its metabolites on seizure occurrence and neuronal physiology. We will examine a microbial-derived metabolite as a key factor in seizure development, which will provide a basis for investigating its role as a therapeutic target in epilepsy.

PI_NAMEs: CAMPBELL, SUSAN LATOYA (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: acquired epilepsy;Action Potentials;Acute;Adult;Affect;Agreement;anti-epileptic agents;astrogliosis;Bacteria;Blood - brain barrier anatomy;Brain;C57BL/6 Mouse;Cells;Cellular Membrane;Central Nervous System;Chronic;daidzein;Data;Death Rate;Defect;design;Development;dietary;Drug resistance;Electroencephalography;Electrophysiology (science);Epilepsy;equol;Frequencies;Genetic;gut bacteria;gut microbes;gut microbiome;gut microbiota;gut-brain axis;Hippocampus;Homeostasis;Induced Neurons;Infection;Inflammation;Injections;innovation;Kainic Acid;Knowledge;large-conductance calcium-activated potassium channels;Link;Liquid Chromatography;Mass Spectrum Analysis;Metabolic;microbial;microbiome;microbiome analysis;microorganism;Modeling;Molecular;mortality;Mus;neglect;Nervous System Disorder;Nervous System Physiology;Neuronal Dysfunction;neuronal excitability;Neurons;neuroprotection;novel;novel strategies;Outcome;patch clamp;Patients;Persons;Phase;Phenotype;Physiological;Physiology;Plasma;Play;Predisposition;Prevalence;Process;Production;Proteins;Publishing;Research;Resistance;Resource-limited setting;Risk Factors;Rodent;Role;Seizures;Signal Pathway;Slice;stool sample;Supplementation;Synapses;synaptic function;Synaptic Transmission;tandem mass spectrometry;targeted treatment;Taxonomy;Temporal Lobe Epilepsy;Test Result;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;TMEV;transcriptome sequencing;Viral;Virus Diseases;voltage;Work

PROJECT_TITLE: Dissecting the role of gut microbial-derived metabolites on epilepsy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative The proposed study will develop novel methods to pinpoint the genetic variant sets associated with the disease. Compared with the existing method, the methods will have a higher power and can be easily customized to various special needs such as preserving data privacy, incorporating functional annotations, and adjusting for varying ancestry loadings for admixed populations. A successful completion of the proposal will lead to both rigorous methodology foundation and useful statistical and computational tools to identify and visualize disease-associated variants.

PI_NAMEs: XIE, JICHUN  (contact)

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: Address;Amyotrophic Lateral Sclerosis;analysis pipeline;Bioconductor;causal variant;Chromosomes;Code;Complex;computerized tools;Computing Methodologies;data preservation;data privacy;Data Protection;Data Set;data sharing;design;Disease;disease mechanisms study;Evaluation;exome sequencing;experience;Foundations;Genes;Genetic Diseases;genetic variant;Genome;Genomics;Goals;Grant;High-Throughput Nucleotide Sequencing;human disease;improved;Individual;insight;Lightning;Mathematics;Measures;Meta-Analysis;Methodology;Methods;mosaic;Mutation;Noise;novel;open source;Output;Pathogenicity;Pattern;Population;Privacy;public repository;rare variant;Research Personnel;Resolution;Secure;Signal Transduction;simulation;Site;software development;Special needs;Speed;Statistical Data Interpretation;Statistical Methods;Technology;Testing;tool;trait;translational study;Untranslated RNA;Variant;virulence gene;Visualization;Visualization software

PROJECT_TITLE: New computational methods to dynamically pinpointing the subregions carrying disease-associated rare variants

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PUBLIC HEALTH STATEMENT This K26 Midcareer Investigator Award expands the candidate’s ability to provide excellent mentoring in behavioral diabetes prevention research to diverse early career researchers. Within the context of intensive ongoing research, the award supports comprehensive mentor training and mentee training in health behaviors for diabetes prevention, health equity, maternal health, and implementation science, leveraging unique UC Davis resources and a transdisciplinary team science approach. These activities support the long-term objective of diversifying the research workforce dedicated to diabetes prevention.

PI_NAMEs: BROWN, SUSAN DENISE (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Academy;Address;Advisory Committees;Appointment;Area;Award;Awareness;Behavior;Behavior Therapy;Behavioral;Behavioral Sciences;Belief;Bioethics;Biometry;career;career development;Center for Translational Science Activities;Clinical Research;Clinical Sciences;clinical translation;Dedications;design;Development;Diabetes Mellitus;Diabetes prevention;digital health;doctoral student;efficacy research;Emotional Intelligence;empowerment;Environment;Epidemiology;Equity;ethnic disparity;evidence base;experience;Faculty;Family;Fostering;Foundations;Funding;Gestational Diabetes;Goals;Grant;Growth;Health behavior;Health Care Research;health equity;Health equity research;Health Sciences;Health Services;Health system;Healthcare Systems;high risk;implementation science;innovation;Institution;Intervention;Intervention Studies;K-Series Research Career Programs;Leadership;Life Style;Link;Maternal Health;maternal risk;Medical Students;member;Mentors;Mentorship;Minority Health Research;minority investigator;Mission;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;peer;Perinatology;Philosophy;Population;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;postpartum weight;pre-doctoral;Prevention Research;primary outcome;programs;Public Health;racial disparity;recruit;Reproducibility;Research;Research Institute;Research Methodology;Research Personnel;Research Training;Resources;responsible research conduct;Science;Scientist;Self Efficacy;skill acquisition;skills;social cognitive theory;Social Sciences;Solid;Stereotyping;success;Syndrome;Time;Training;Training Activity;Underrepresented Minority;Underrepresented Populations;Underserved Population;United States National Institutes of Health;volunteer;Weight maintenance regimen;Woman;women's prevention;Writing

PROJECT_TITLE: Mentoring Diverse Early Career Researchers in Behavioral Diabetes Prevention Research


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE The primary goal of the proposed research to investigate the genetic and environmental architecture of cardiometabolic traits across ethnic groups in the All of Us cohort. Both genetics and environment influence disparities in cardiometabolic health span and disease, thus, understanding differences between ethnic groups will be essential to realize precision medicine goals. We will implement software workflows into the All of Us Researcher Workbench to accomplish the research and make them available to the broader community.

PI_NAMEs: O'CONNELL, JEFFREY R (contact)

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: Accounting;Address;Adoption;African American population;Age;Algorithms;Alleles;APOL1 gene;Architecture;Biological;Blood Pressure;Body mass index;burden of illness;cardiometabolism;Cardiovascular Diseases;clinical phenotype;cohort;Communities;Complex;Computer software;Data;Data Set;Disease;disease disparity;Disparity;Early Intervention;Educational Activities;Environment;Environmental Exposure;Environmental Risk Factor;ethnic minority;Ethnic Origin;Ethnic Population;Evolution;Functional disorder;Gender;gene environment interaction;Genes;Genetic;Genetic Variation;genome wide association study;genome-wide;genome-wide analysis;Genotype;Glucose;Goals;health disparity;healthspan;Heritability;human disease;insight;Instruction;Investigation;Kidney Diseases;Learning;lifestyle factors;Lipids;Manuals;Modeling;non-diabetic;Physical activity;Population;precision medicine;Prevalence;Prevention;racial minority;Reliability of Results;Research;Research Personnel;Resources;Risk;Running;rural area;sex;Sexual and Gender Minorities;Shapes;Smoking;social determinants;Software Tools;Source;Testing;Therapeutic;tool;Training;trait;Treatment Factor;urban area;whole genome

PROJECT_TITLE: Elucidating the ancestry-specific genetic and environmental architecture of cardiometabolic traits across All of Us ethnic groups


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: The DPPOS AD/ADRD project will address the overarching question: What are the determinants and the nature of cognitive impairment among persons with pre-diabetes (PreD) and type 2 diabetes (T2D), who are a high-risk group for cognitive impairment and represent a large fraction of the United States (US) population? This U19 proposal addresses the National Alzheimer’s Project Act goal to “prevent, halt, or reverse AD” in the high-risk group of persons with pre-diabetes and type 2 diabetes, who represent over half of the population aged 60 years and older in the US.

PI_NAMEs: LUCHSINGER, JOSE ALEJANDRO (contact);NATHAN, DAVID M;TEMPROSA, MARINELLA

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Acceleration;Address;adjudication;Age;aged;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid;amyloid imaging;Behavioral;biobank;Biological Markers;Biometry;Blood Vessels;Brain;Brain imaging;Cerebrovascular Disorders;Clinical;Cognition Disorders;cognitive testing;cohort;Cohort Studies;Complex;data infrastructure;data management;Data Set;Dementia;dementia risk;Development;diabetes prevention program;ethnic minority;Exposure to;extracellular vesicles;frailty;Funding;Glucose;Goals;high risk;high risk population;human old age (65+);Hyperinsulinism;Impaired cognition;insulin signaling;Knowledge;Lead;life span;Life Style;macrovascular disease;Magnetic Resonance Imaging;Measurement;Measures;Metabolic;Metformin;mild cognitive impairment;Nature;Nerve Degeneration;neuroimaging;neuroinflammation;Neurons;neuropathology;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Observational Study;operation;Outcome Study;Participant;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Physical activity;Physical Function;Placebos;Plasma;Population;Positron-Emission Tomography;Prediabetes syndrome;prevent;Procedures;racial minority;Randomized Controlled Clinical Trials;Reading;Research;Role;Sampling;segregation;Site;sociodemographics;tau Proteins;Time;United States;vascular cognitive impairment and dementia;Woman

PROJECT_TITLE: Alzheimer's Disease and Alzheimer's Disease Related Dementias in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Outcomes Study AD/ADRD Project


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Diabetes;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: LUCHSINGER, JOSE ALEJANDRO (contact)

PROJECT_TERMS: Adherence;Adopted;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Ancillary Study;Budgets;career development;clinical center;clinical research site;Cognitive;Collaborations;data sharing;Development;Diabetes Mellitus;diabetes prevention program;Education;education research;Ensure;experience;Funding;Goals;Institutional Review Boards;Journals;Leadership;Ligands;Manuscripts;Measurable;meetings;Mentorship;Minority;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute on Aging;Non-Insulin-Dependent Diabetes Mellitus;Observational Study;Outcome;Outcome Study;Participant;Peer Review;Prediabetes syndrome;Preparation;Prevention Guidelines;Prevention program;Principal Investigator;Procedures;programs;Progress Reports;Protocols documentation;Publications;Reading;Reporting;Research;Research Personnel;Resources;Scientist;Site;Structure;success;Travel;United States;United States Centers for Medicare and Medicaid Services;Universities;Update;Washington;web site;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Diabetes;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: TEMPROSA, MARINELLA  (contact)

PROJECT_TERMS: adjudication;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Biochemistry;Biological Assay;Biological Markers;Biometry;Brain imaging;Cardiology;Cardiovascular Diseases;Cardiovascular system;Cerebrovascular Disorders;Certification;Cessation of life;Clinical;clinical center;clinical research site;clinically significant;Cognition;Cognitive;cognitive testing;Collection;college;Communities;Data;Data Collection;data standards;diabetes control;diabetes prevention program;Diagnostic;Disease Outcome;Electrocardiogram;Ensure;Epidemiology;Event;extracellular vesicles;Goals;Hospitalization;Laboratories;Leadership;Manuals;Measurement;Measures;Medicine;meetings;Minnesota;Monitor;National Institute on Aging;neuroimaging;Neuropathy;Non-Insulin-Dependent Diabetes Mellitus;operation;Outcome;Outcome Study;Participant;participant retention;Performance;Persons;Phase;Physical activity;Physical Function;Plasma;Prediabetes syndrome;Procedures;Process;programs;Protocols documentation;Quality Control;Reading;remote visit;Reporting;Research;Research Personnel;Risk Factors;Sampling;Schedule;Shipping;Specimen;Standardization;Stroke;success;Training;Universities;Vendor;virtual;Visit;Washington;web site;Work

PROJECT_TITLE: Clinical Operations and Procedures Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Diabetes;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: GOLDBERG, TERRY  (contact)

PROJECT_TERMS: adjudication;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Ancillary Study;Biological Markers;Biometry;Brain imaging;cerebrovascular;Certification;Classification;Clinical;Cognition;Cognition Disorders;Cognitive;cognitive testing;Collaborations;Communities;Data;Data Collection;data infrastructure;Data Set;Dedications;Dementia;diabetes prevention program;Diagnosis;Digit structure;Doctor of Philosophy;Electronic Mail;Ensure;executive function;experience;Goals;Human Resources;Impaired cognition;improved;Lead;Magnetic Resonance Imaging;Manuals;Measures;mental state;mild cognitive impairment;Mind;Multi-Ethnic Study of Atherosclerosis;Nerve Degeneration;neuroimaging;Non-Insulin-Dependent Diabetes Mellitus;operation;Outcome Study;Participant;Pathologic;Physicians;Plasma;Positron-Emission Tomography;Prediabetes syndrome;Primary Care;Procedures;Process;processing speed;quality assurance;Quality Control;Recording of previous events;Research;Resolution;Site;Smell Perception;Spanish/English;Stroke;tau Proteins;Testing;Time;Training;Update;vascular cognitive impairment and dementia;Verbal Learning;web site;Work

PROJECT_TITLE: Cognitive Assessment and Adjudication Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Complementary and Integrative Health;Dementia;Dietary Supplements;Microbiome;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: COLUMBIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Narrative Increasing evidence supports that neurodegeneration resulting in the onset of Alzheimer’s Disease could be linked to imbalances in the diversity and composition of microbes in the gut. This imbalance, or dysbiosis, has been shown to be linked to neuroinflammation resulting in neurodegeneration and impaired cognition. We propose the first study linking human and preclinical models for gut-brain axis using ultrahigh field 7 Tesla multi- modal magnetic resonance imaging with a mechanistic and interventional study design to enhance our understanding of gut-brain interactions underlying neurodegeneration in AD and pave the way for future disease- modifying interventions for AD via microbiome-gut-brain axis.

PI_NAMEs: BALCHANDANI, PRITI ;LIN, AI-LING  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: 3xTg-AD mouse;Acceleration;Adverse effects;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Animal Experiments;Animals;Area;Bacteroides;Biochemical;Biological Assay;Brain;Brain region;brain volume;Cerebrovascular Circulation;Classification;Clinical Trials;Cognition;Cognitive;cognitive function;cognitive testing;Data;Dementia;design;Diet;dietary control;Disease;Disease Progression;dysbiosis;effective intervention;Equilibrium;Escherichia coli;extracellular;fecal transplantation;Female;Future;Gene Expression;Goals;gut dysbiosis;gut microbes;gut microbiome;gut-brain axis;Hippocampus;Human;human model;human study;imaging biomarker;Impaired cognition;Individual;Inflammatory;Intervention;Intervention Studies;Inulin;Knock-out;Knockout Mice;Knowledge;Link;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Microbe;microbial community;microbiome;microbiome analysis;microbiome composition;microbiome sequencing;microbiota;mouse model;multimodality;Mus;Nerve Degeneration;Neurofibrillary Tangles;neuroimaging marker;neuroinflammation;neuropathology;neuroprotection;Nitric Oxide Synthetase Inhibitor;NOS2A gene;novel;Outcome;Participant;pathogenic bacteria;Physiology;Positioning Attribute;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;prebiotics;recruit;Research Design;Senile Plaques;Severities;sex;Stains;stool sample;success;Supplementation;tau Proteins;Testing;transcriptomics;Transgenic Organisms;translational study;Transplantation;ultra high resolution;Volatile Fatty Acids;white matter

PROJECT_TITLE: Gut-brain axis in Alzheimer's disease: translational 7T MRI markers and underlying mechanisms


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Diabetes;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: NASRALLAH, ILYA M (contact)

PROJECT_TERMS: adjudication;aged;aging brain;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;analysis pipeline;Biological Assay;Biological Markers;Biometry;Brain;Brain imaging;brain magnetic resonance imaging;cerebrovascular;Cerebrovascular Circulation;Certification;Clinical;Cognition;Cognitive;cognitive testing;Cohort Studies;Collaborations;Communities;Data;data infrastructure;Dementia;diabetes prevention program;Diffusion Magnetic Resonance Imaging;Disease;Evaluation;Feedback;Functional Magnetic Resonance Imaging;Glial Fibrillary Acidic Protein;Goals;Image;imaging biomarker;Impaired cognition;innovation;Laboratories;Lead;Light;Machine Learning;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maintenance;Manuals;Measurement;Measures;Methods;molecular array;multimodality;National Institute on Aging;Nature;Nerve Degeneration;neurofilament;neuroimaging;neuroinflammation;neuropathology;Non-Insulin-Dependent Diabetes Mellitus;operation;Outcome;Outcome Study;Participant;Pennsylvania;Peripheral Nervous System Diseases;peripherin;Persons;Plasma;Population;Positron-Emission Tomography;Prediabetes syndrome;Procedures;Protocols documentation;Qualifying;quality assurance;Quality Control;Recording of previous events;remediation;Research;Risk;Sampling;Site;Stroke;structural imaging;tau Proteins;therapeutic target;tool;Training;Universities;Update;vascular cognitive impairment and dementia;Water

PROJECT_TITLE: Neuroimaging and Plasma Biomarkers Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Data Science;Dementia;Diabetes;Neurodegenerative;Neurosciences;Prevention

PROJECT_TERMS: Address;Adherence;adjudication;Alzheimer's Disease;Alzheimer's disease related dementia;Ancillary Study;Biological Markers;Biological Specimen Banks;Biometry;Clinic;Clinical;Cognition;Cognitive;cognitive testing;Collaborations;Custom;Data;data acquisition;Data Analyses;Data Collection;data enclave;data infrastructure;data integration;data integrity;data management;data quality;data repository;Data Set;data warehouse;design;Development;diabetes prevention program;Ensure;Goals;Infrastructure;Lead;longitudinal analysis;Manuscripts;Mentors;Monitor;multimodality;National Institute on Aging;neuroimaging;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Online Systems;operation;Outcome;Outcome Study;Persons;Plasma;Play;Prediabetes syndrome;Procedures;Process;programs;Progress Reports;Protocols documentation;Publications;Quality Control;Reporting;repository;Research Design;Research Personnel;Role;Safety;Sample Size;Standardization;Statistical Data Interpretation;synergism;System;Training;United States National Institutes of Health;Universities;Validation;validation studies;Washington;web site

PROJECT_TITLE: Biostatistics and Data Infrastructure core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE Despite the allure of cancer precision medicine, at present most patients do not benefit from this approach. Only a minority of patients receive therapy that is guided by the molecular features of their tumor. This research proposal aims to open the scientific bottlenecks that currently limit the utility of cancer precision medicine.

PI_NAMEs: GOLUB, TODD R. (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Acceleration;Address;Cell model;Cell Survival;Cells;Clinical;Communities;Complex;Data Set;Diagnostic;DNA;drug action;Drug resistance;drug response prediction;drug sensitivity;Gene Expression;Genetic Predisposition to Disease;Genomics;Immune;in situ sequencing;insight;Maps;Mediating;Methods;Minority;Modeling;Molecular;neoplastic cell;Organoids;Patients;Pre-Clinical Model;precision oncology;Primary Neoplasm;public health relevance;Research;Research Proposals;RNA;Testing;tumor;tumor microenvironment

PROJECT_TITLE: Making cancer precision medicine real: bottlenecks and opportunities


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Diabetes;Mental Health;Neurodegenerative;Neurosciences;Prevention;Sleep Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: NOBLE, JAMES MCCALLUM (contact)

PROJECT_TERMS: adjudication;aged;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Amyloid beta-42;Attenuated;Behavioral;Biological Markers;Brain imaging;Categories;Cerebrovascular Disorders;Characteristics;Classification;Cognition;Cognition Disorders;cognitive testing;Cohort Studies;Collaborations;Dementia;depressive symptoms;diabetes prevention program;Education;epidemiology study;Ethnic Origin;Ethnic Population;extracellular vesicles;Female;Glial Fibrillary Acidic Protein;Goals;high risk;high risk population;imaging biomarker;Impaired cognition;Incidence;Infarction;Insulin;insulin receptor substrate 1 protein;Insulin Resistance;insulin signaling;IRS1 gene;Knowledge;Light;literacy;Measures;Metabolic;mild cognitive impairment;National Institute on Aging;Nerve Degeneration;neurofilament;neuroimaging;neuroinflammation;Neurons;neuropathology;neurophysiology;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Obstructive Sleep Apnea;Outcome Study;Participant;Pathologic;Pathology;Peripheral;Persons;Pharmaceutical Preparations;Plasma;poor sleep;Population;Positron-Emission Tomography;Prediabetes syndrome;Prevalence;Prevention;Proto-Oncogene Proteins c-akt;Race;racial population;Research;Rest;Risk;Sampling;sex;sex variable;Sleep disturbances;sleep quality;sociodemographic factors;sociodemographics;Structure;tau Proteins;Thick;Tyrosine;United States;vascular cognitive impairment and dementia;Vascular Dementia;white matter;White Matter Hyperintensity

PROJECT_TITLE: Cognitive impairment in the DPPOS cohort and its neuropathologic, neurophysiologic, sociodemographic, and behavioral correlates


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Diabetes;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: DABELEA, DANA  (contact)

PROJECT_TERMS: adjudication;Advanced Glycosylation End Products;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Amyloid beta-42;Amyloid beta-Protein;apolipoprotein E-4;Beta Cell;Biological Markers;Blood Pressure;Blood Vessels;Brain;Brain imaging;Brain Pathology;Buffers;Classification;Clinical;Cognition Disorders;Cognitive;cognitive reserve;cognitive testing;Collaborations;Coronary Arteriosclerosis;Data;Defect;Dementia;diabetes mellitus genetics;diabetes prevention program;Dyslipidemias;Education;Educational Status;endothelial dysfunction;Ethnic Origin;extracellular vesicles;Functional disorder;Genetic Risk;genetic risk factor;Glial Fibrillary Acidic Protein;Goals;high risk;imaging biomarker;Impaired cognition;Impairment;Infarction;Inflammation;Insulin Resistance;insulin signaling;Investigation;Kidney Diseases;Light;literacy;macrovascular disease;Magnetic Resonance Imaging;Measures;Mediating;Microvascular Dysfunction;mild cognitive impairment;modifiable risk;Myocardial Infarction;neurofilament;neuroimaging;Neurons;neuropathology;Neuropathy;neurophysiology;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Outcome Study;Participant;Pathologic;Peripheral;Persons;Plasma;Positron-Emission Tomography;Prediabetes syndrome;predictive modeling;Prevention strategy;Race;Recording of previous events;Retinal Diseases;Risk;Risk Factors;risk prediction;Severities;sex;sociodemographic factors;Stroke;Structure of beta Cell of islet;Syndrome;tau Proteins;Thick;Thinness;Time;treatment strategy;vascular contributions;vascular factor;White Matter Hyperintensity

PROJECT_TITLE: Association of glycemia and related factors and complications with cognitive impairment and AD/ADRD biomarkers


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: The proposed project will provide a mentorship to predoctoral and postdoctoral scholars from diverse backgrounds who are conducting research within the mission of NIDDK. The PI will provide theory-driven and evidence-based interventions that target scientific self-efficacy and identity to increase perseverance to achieve a career as a researcher. The goal of the program is for mentees to become independent investigators with a program of funded research focused on risk for type 2 diabetes and related conditions.

PI_NAMEs: FLOWERS, ELENA  (contact)

PROJECT_TERMS: Address;Affect;African American population;Area;Asian population;Award;Awareness;Biological Markers;Biology;biomarker discovery;Black Populations;career;career development;Career Mobility;Caregivers;Categories;Caucasians;Characteristics;cohort;Communities;Complex;cost;Data;demographics;Development;disability;Disadvantaged;Disease;Disparity;Doctor's Degree;Education;Educational workshop;ethnic minority population;Ethnic Origin;Etiology;evidence base;Evidence based intervention;experience;Funding;Future;Gender;Genetic;Genetic Predisposition to Disease;Goals;Grant;health equity;health science research;Health Sciences;high school;Hispanic Populations;improved;Individual;information processing;innovation;Intervention;Journals;Latinx;Lead;long-standing disparities;Mediating;men;Mentors;Mentorship;Mission;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel marker;outcome disparities;Patients;Persons;Phase;Population;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Prevalence;Prevention;Principal Investigator;Program Development;programs;psychosocial;Publishing;Qualifying;Race;racial minority population;recruit;Research;Research Personnel;Resources;response;Risk;Risk Reduction;role model;Scholars Program;Science;science, technology, engineering, mathematics, and medicine;Self Efficacy;skills;social;Social Impacts;Social support;Socioeconomic Status;Strategic Planning;success;Target Populations;theories;Training;transcriptomics;Underrepresented Populations;United States;Woman;women versus men;Writing

PROJECT_TITLE: Mentorship of Individuals from Historically Under-Represented Groups in Health Sciences Research


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Diabetes;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PROJECT_TERMS: adjudication;Advanced Glycosylation End Products;Agonist;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;apolipoprotein E-4;Atrophic;Biguanides;Biological Markers;Brain;Brain imaging;brain magnetic resonance imaging;Categories;Cerebrovascular Disorders;Classification;Cobalamin;Cognition Disorders;Cognitive;cognitive benefits;cognitive reserve;cognitive testing;Cohort Studies;Collaborations;Data;Dementia;Diabetes prevention;diabetes prevention program;Dipeptidyl Peptidases;Endothelium;Ethnic Origin;Exposure to;genomic signature;Glial Fibrillary Acidic Protein;GLP-I receptor;Glucose;Goals;Hemorrhage;Impaired cognition;Infarction;Inflammation;inhibitor;Insulin;insulin signaling;Light;Mediating;Mediator;Metformin;mild cognitive impairment;Modification;National Institute on Aging;Nerve Degeneration;neurofilament;neuroimaging;neuroinflammation;Neurons;neuropathology;neuroprotection;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Outcome Study;Participant;Peripheral;Persons;Pharmaceutical Preparations;Pharmacotherapy;Physical activity;Plasma;Positron-Emission Tomography;Prediabetes syndrome;racial population;Randomized;Research;Rest;Risk;sex;side effect;Sodium;Statistical Methods;Structure;Sulfonylurea Compounds;symporter;Syndrome;tau Proteins;Thiazolidinediones;Thick;vascular cognitive impairment and dementia;vascular risk factor;white matter;White Matter Hyperintensity

PROJECT_TITLE: Association of cumulative exposure to metformin and other T2D medications with cognitive impairment and AD/ADRD biomarkers


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Kidney Disease;Lung;Prevention

ORG_CITY: FRAMINGHAM

ORG_NAME: BESSOR PHARMA, LLC

PHR: PROJECT NARRATIVE Viral pandemics (e.g., Spanish flu, H1N1/influenza, and COVID-19) have taken a huge toll on human health and welfare. Organ injury and death from viral infections are increasingly recognized to result from an imbalance in the host immune response as well as tissue damage caused by the virus. The proposed studies will employ preclinical models to test a new therapeutic that that uses a novel mechanism to rebalance the host immune response as well as protect tissue from virus-induced damage. It has the potential to prevent deaths from COVID-19, regardless of evolving viral variants.

PI_NAMEs: BERKOWITZ, BARRY A (contact);DESIR, GARY V.

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;Active Sites;Acute;Adrenal Cortex Hormones;Agonist;Amino Acids;Animal Model;Anti-Inflammatory Agents;Antiinflammatory Effect;Apoptosis;Biological Assay;Blood;Blood Vessels;Body Weight decreased;Cell Death;cell injury;Cell Survival;Cessation of life;chemical synthesis;Chronic;COVID-19;COVID-19 complications;COVID-19 morbidity;COVID-19 mortality;COVID-19 patient;COVID-19 severity;COVID-19 therapeutics;COVID-19 treatment;cytokine;cytokine release syndrome;Data;design;Dose;Dose Limiting;Drug Kinetics;Enzyme-Linked Immunosorbent Assay;Equilibrium;Evaluation;Exposure to;Freezing;Future;Growth;Health;Heart Injuries;High Pressure Liquid Chromatography;Histopathology;Hospitalization;Hour;Human;humanized mouse;IL-6 inhibitor;IL6 gene;Immune response;Immunologics;improved;in vivo;Inflammation;Inflammatory;Inflammatory Infiltrate;Inflammatory Response;Influenza;Influenza A Virus, H1N1 Subtype;Infusion procedures;Injury;Injury to Kidney;innovation;Integration Host Factors;Interleukin-1 beta;Interleukin-6;Intravenous;Intravenous infusion procedures;Kidney;kidney cell;Length;Lung;manufacture;Measurement;Mitogen-Activated Protein Kinases;Modeling;mortality;mouse model;multiple myeloma M Protein;Mus;new therapeutic target;novel;novel therapeutics;Onset of illness;organ injury;Pancreatitis;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;Pharmacology Study;Plasma;PMCA1 protein;Poly I-C;pre-clinical;Pre-Clinical Model;preservation;prevent;Prevention;Production;protein complex;Proteins;Proto-Oncogene Proteins c-akt;Publishing;Rattus;receptor;Recombinants;response;Rodent;Route;SARS-CoV-2 immune response;SARS-CoV-2 infection;secretory protein;severe COVID-19;Severities;Severity of illness;Shapes;side effect;Signal Transduction;Site;Spanish flu;Specific qualifier value;subcutaneous;synergism;Technology;Temperature;Testing;Therapeutic;Therapeutic Index;Therapeutic Uses;therapeutically effective;Time;tissue injury;Tissues;TNF gene;Toxic effect;UV Radiation Exposure;Vaccines;Variant;Viral;Viral Load result;viral pandemic;Virus;Virus Diseases;welfare

PROJECT_TITLE: New target and new therapy for severe Covid-19 and viral hyperinflammation damage: renalase and renalase agonists

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(10)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Diabetes;Neurodegenerative;Neurosciences;Nutrition;Physical Activity;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: PALTA, PRIYA  (contact)

PROJECT_TERMS: Adult;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Amyloid beta-42;apolipoprotein E-4;Biological Markers;Blood Vessels;Body mass index;Brain;Brain imaging;Brain-Derived Neurotrophic Factor;Cerebrovascular Disorders;Cognition;Cognitive;cognitive function;cognitive reserve;comorbidity;Complex;Data;Dementia;Development;Diabetes prevention;diabetes prevention program;Educational Status;Enrollment;Ethnic Origin;Exercise;frailty;Glial Fibrillary Acidic Protein;Goals;imaging biomarker;Impaired cognition;Individual;Inflammation;Insulin-Like Growth Factor I;Joints;late life;Life Style;lifestyle intervention;Light;Lower Extremity;macrovascular disease;Measures;Mediating;Mediator;Metabolic;metabolic phenotype;middle age;mild cognitive impairment;Modeling;Muscle;Nerve Degeneration;neurofilament;neuroinflammation;neuropathology;Non-Insulin-Dependent Diabetes Mellitus;older adult;Outcome;Outcome Study;Participant;Peripheral;Persons;Phenotype;Physical activity;Physical Function;Plasma;Population;Prediabetes syndrome;preservation;prevent;Race;Randomized;Research;Risk;sex;tau Proteins;tau-1;Thick;Vascular Diseases;β-amyloid burden

PROJECT_TITLE: Physical activity, physical function, and frailty in relation to cognitive impairment and AD/ADRD biomarkers in DPPOS


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Bioengineering;Celiac Disease;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Health Services;Nutrition;Telehealth

PHR: PROJECT NARRATIVE We propose to plan for a multi-center randomized controlled trial (M-RCT) to test the effectiveness of novel gluten detection technologies as an adjunct to telemedicine to manage celiac disease in newly diagnosed adults. If successful, the proposed intervention will improve mucosal recovery, promote a shift in current practice of celiac disease management toward long-term monitoring, and represent a significant step toward reducing the severe physical and psychological consequences of celiac disease.

PI_NAMEs: LEBWOHL, BENJAMIN  (contact);WOLF, RANDI L.

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adoption;Adult;Affect;Anemia;Antibodies;antigen test;Anxiety;Autoantibodies;Awareness;Behavioral;Celiac Disease;Chemistry;Clinical;clinical development;Clinical Management;Clinical Trials;Communication;comparative cost effectiveness;Complement;Consumption;cost;cost comparison;cost effective;cost effectiveness;Country;COVID-19 pandemic;deamidation;Detection;Diagnosis;dietary;dietary adherence;Dietitian;Digestive System Disorders;Disease Management;Eating Behavior;Effectiveness;effectiveness evaluation;effectiveness testing;Evaluation;Fatigue;follow-up;Food;Gastroenterology;gastrointestinal symptom;Gliadin;Gluten;Gluten-free diet;Grant;Health;Health Professional;Height;Histology;Home;Illinois;Immune System Diseases;immunogenic;Immunoglobulin A;Immunoglobulin G;improved;Incidence;Individual;Infertility;Infrastructure;Intervention;intraepithelial;Link;Lymphocyte Count;Malignant Neoplasms;Massachusetts;Measures;Mediator;meetings;Mental Depression;Monitor;Morbidity - disease rate;mortality;Motivation;Mucous Membrane;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;New York;Newly Diagnosed;novel;Osteoporosis;Outcome;Outcome Study;pandemic disease;Participant;Pathway interactions;Patient-Focused Outcomes;Patients;Peptide antibodies;Peptides;Performance;Persons;Physicians;Pisum sativum;Population;portability;primary endpoint;primary outcome;psychologic;Quality of life;Randomized;Randomized, Controlled Trials;rapid testing;Recommendation;Recovery;recruit;Regimen;Sample Size;Sampling;SARS-CoV-2 antigen;secondary outcome;sensor;Serology;Seroprevalences;Serum;social;Social support;standard of care;Symptoms;Technology;Telemedicine;Tennessee;Testing;Tissue Transglutaminase Antibodies;tool;Translating;United States;Urine;validation studies;Videoconferencing;Villus

PROJECT_TITLE: Evaluation of Novel Technologies to Improve Clinical Management of Celiac Disease: The GLUTECH Trial


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: Project Narrative As the number of rare disorders grow each year, the need for new treatments, approaches, and understanding continues to expand. This program has a five-year track record of successfully increasing early career clinical researcher’s intent to remain in research. By continuing the successful program, expanding to a broader group of clinical researchers, and creating an alumni longitudinal component, this program will continue to support the clinical research pipeline.

PI_NAMEs: BATSHAW, MARK L.;REGIER, DEBRA S (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Address;Adult;care delivery;career;Clinical;Clinical Research;Collaborations;Communities;Creativeness;Discipline;Education;Education Projects;education research;Educational Curriculum;Educational process of instructing;Environment;experience;Family;flexibility;Future;Genetic;Goals;health equity;health equity promotion;improved;Individual;Institutional Racism;Learning Skill;lectures;Medicine;Mentors;Mentorship;Minority Groups;Modeling;multidisciplinary;next generation;non-genetic;Participant;Patients;Personal Satisfaction;Persons;Population;programs;Rare Diseases;recruit;Research;Research Personnel;Science;skills;theories;Therapeutic;Training;Training Programs;Translational Research;Underrepresented Populations;virtual

PROJECT_TITLE: Rare Disease Clinical Research Training Program

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Neuroblastoma is an aggressive pediatric cancer with a poor prognosis despite an intensive multimodal treatment regimen. This proposal aims to advance an experimental immunotherapeutic nanomedicine toward clinical translation through optimization of physiochemical and biological properties, rigorous preclinical evaluation in animal models of neuroblastoma, and optimization of combination immunoregimens.

PI_NAMEs: WILSON, JOHN TANNER (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Acceleration;Accounting;Address;Adult;advanced disease;Agonist;Animal Model;Biodistribution;Biological;cancer cell;CAR T cell therapy;Cessation of life;Child;Childhood Extracranial Solid Tumor;Childhood Solid Neoplasm;chimeric antigen receptor T cells;Clinic;Clinical;clinical translation;Combination immunotherapy;Combined Modality Therapy;Cytosol;Data;design;Development;Dinucleoside Phosphates;Disease;Drug Delivery Systems;Drug Kinetics;Enhancement Technology;experience;fabrication;Formulation;Foundations;Gene Activation;Generations;Half-Life;high risk;human disease;Immune;immune checkpoint blockade;Immune Evasion;Immunocompetent;immunoengineering;immunogenicity;Immunologic Memory;Immunologic Stimulation;Immunologics;Immunooncology;Immunotherapeutic agent;Immunotherapy;improved;Industrialization;Malignant Childhood Neoplasm;manufacturing process;materials science;Methods;Modality;Modeling;Molecular Weight;mouse model;multidisciplinary;multimodality;nano;nanofabrication;nanomedicine;nanoparticle;Nanotechnology;Natural Immunity;Neoplasm Metastasis;Neuroblastoma;next generation;novel;novel therapeutics;Outcome;Particle Size;Pathway interactions;Patients;Pediatric Oncology;Periodicity;Pharmacodynamics;Pharmacologic Substance;Plasma;Polymers;pre-clinical;Precipitation;preclinical development;preclinical evaluation;prevent;Prognosis;programs;Property;Protocols documentation;rational design;Recurrence;Recurrent disease;Regimen;Reproducibility;Research;response;Safety;Science;Signal Transduction;Site;Solid Neoplasm;Stimulator of Interferon Genes;systemic toxicity;T cell infiltration;T-cell inflamed;Therapeutic;therapeutic target;Toxic effect;Translating;Translations;Treatment Efficacy;Treatment outcome;Treatment Protocols;treatment response;tumor;tumor growth;Tumor Immunity;tumor immunology;tumor microenvironment;uptake;Vesicle;Work

PROJECT_TITLE: Toward Translation of an Immunotherapeutic Nanomedicine for Neuroblastoma


NIH_SPENDING_CATS: Aging;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PROVIDENCE

ORG_DEPT: BIOLOGY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative (NIH) We propose the Hallmarks of Aging are mediated and coordinated by the branches of methionine metabolism: the methionine cycle, the transsulfuration pathway and the polyamine/salvage pathway. Nutrient sensing, itself a Hallmark of Aging, strongly impacts methionine metabolism through signaling from the insulin/IGF receptor. We will use novel mutants of the Drosophila insulin receptor to dissect how methionine metabolism integrates the Hallmarks of Aging.

PI_NAMEs: PARKHITKO, ANDREY A;TATAR, MARC  (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Affect;Age;age related;age related changes;Aging;aging process;Consensus;detection of nutrient;Diet;Drosophila genus;Epigenetic Process;epigenome;extend lifespan;Female;fly;genetic manipulation;Genome Stability;Genotype;Germ Lines;germline stem cells;Geroscience;hallmarks of aging;healthspan;Heterochromatin;histone methylation;insight;Insulin;Insulin Receptor;Insulin Resistance;insulin sensitivity;insulin signaling;Insulin-Like Growth Factor Receptor;Intervention;Intestines;Isotope Labeling;life span;Longevity;male;Measures;Mediating;metabolomics;Methionine;Methionine Metabolism Pathway;Mitochondria;mortality;Muscle;muscle aging;mutant;Mutation;novel;Nutrient;pathogen;Pathway interactions;Phosphotransferases;Polyamines;Production;Proliferating;proteostasis;Regulation;Resistance;response;RNA;stem cell proliferation;stem cells;Stress;stress resilience;Testing;Time;Tissues;Transgenes

PROJECT_TITLE: Methionine Cycle as a Mechanistic Hub for the Hallmarks of Aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-Z(52)]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Pediatric

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative This proposal requests competitive continuation funding for renewal of a postdoctoral Ruth L. Kirschstein National Research Service Award Institutional Research Training Program (T32) at UCLA for 5 years for the funding of 6 postdoctoral positions per year. The focus of the training program is on training researchers in the area of clinical translational intervention science for child mental disorders to prepare them to become independent transdisciplinary investigators. During the 2-year training period, postdoctoral researchers will mentored independent research under the mentorship of a primary and secondary mentor, develop core competencies for clinical research, receive formal didactic and experiential training in a designated area of research, as well as training in ethical issues in research and the responsible conduct of research involving children and families.

PI_NAMEs: MCCRACKEN, JAMES T.;PIACENTINI, JOHN C. (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Child Mental Health;Science;Training

PROJECT_TITLE: Training the Science of Child Mental Health Treatment


NIH_SPENDING_CATS: Aging;Biotechnology;Gene Therapy;Genetics;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: NARRATIVE While nine hallmarks of the aging process have been described to date, little is known about their interconnectivity and the hierarchies governing these interactions. Our proposal aims to develop and utilize cellular therapy as both a somatic tool to dissect the spatial and temporal hierarchies as well as a potential therapeutic for the treatment of age-related diseases.

PI_NAMEs: AMOR VEGAS, CORINA  (contact)

PROJECT_TERMS: Affect;age acceleration;Age related pathologies;age-related disease;Aging;aging process;antagonist;Antigens;Atherosclerosis;Biology;Biology of Aging;Breeding;Categories;Cell Aging;Cell Therapy;Cells;cellular engineering;Chemicals;chimeric antigen receptor T cells;Complex;Consumption;cost;Dasatinib;Data;deregulated nutrient-sensing;design;detection of nutrient;Development;Dose;Engineering;Epigenetic Process;experimental study;flexibility;gastrointestinal system;Genomic Instability;Goals;hallmarks of aging;healthspan;improved;Individual;insight;intercellular communication;irradiation;life span;Light;Mitochondria;mitochondrial dysfunction;Modeling;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;old mice;pathological aging;Phenotype;Physiological;Process;programs;proteostasis loss;Research;Resources;response;Safety;senescence;senescent cell;senolytics;small molecule;Specificity;stem cell exhaustion;Surface;Technology;Telomere Shortening;Therapeutic;therapeutic evaluation;Therapeutic Studies;Time;Tissues;tool;Toxic effect;Use Effectiveness;Work

PROJECT_TITLE: Harnessing CAR T cells to deconstruct the interconnectivity among hallmarks of aging


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: PROJECT NARRATIVE Medulloblastoma is the most common malignant pediatric brain tumor and Group 3 medulloblastoma is the most aggressive form of this disease, which is mostly refractory to immunotherapies. This project will dissect the crosstalks between tumor and tumor microenviorment and the mechansims of immune evasion in Group 3 medulloblsatoma. We will also investigate cellular therapy strategies that will circumvent tumor-mediated immunosuppressive mechanisms and reinvigorate anti-tumor immunity in this devastating disease.

PI_NAMEs: CHI, HONGBO  (contact);YU, JIYANG

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Address;Adoptive Cell Transfers;Atlases;Biology;Brain Neoplasms;Cancer Etiology;cancer type;CAR T cell therapy;CD8-Positive T-Lymphocytes;Cell Communication;Cell Physiology;Cell Therapy;Cells;Cellular biology;Child;childhood cancer mortality;Childhood Malignant Brain Tumor;chimeric antigen receptor T cells;Classification;clinically relevant;cloud based;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;Data;data visualization;Development;Disease;disorder risk;Exclusion;Exhibits;experimental study;functional genomics;Genetic;Genetically Engineered Mouse;Genomics;Goals;Heterogeneity;high risk;high risk population;Human;Immune;Immune Evasion;Immunocompetent;Immunology;Immunotherapeutic agent;Immunotherapy;improved;in vivo;insight;Joints;Macrophage;Maps;Mediating;Medulloblastoma;Modeling;Molecular;mouse model;Multiomic Data;multiple omics;Mus;neoplastic cell;nerve stem cell;Network-based;notch protein;novel;overexpression;Patients;Phenotype;Pre-Clinical Model;Proteomics;PTPRC gene;Refractory;Resistance;Reverse engineering;Saint Jude Children's Research Hospital;Sampling;screening;Signal Transduction;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;Sorting;spatiotemporal;stemness;Subgroup;System;Systems Biology;T cell response;T cell therapy;T-Lymphocyte;TCF Transcription Factor;Technology;Testing;tool;transcriptomic profiling;transcriptomics;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Tumor stage;tumor-immune system interactions;Tumor-infiltrating immune cells;Visualization

PROJECT_TITLE: Enabling immunotherapy for high-risk Group 3 medulloblastoma via systems immunology


NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: San Francisco

ORG_NAME: SOCIETY FOR THE ADV CHICANOS/NATIVE AMER

PHR: Narrative SACNAS, the Society for Advancement of Chicanos/Hispanics and Native Americans in Science, is an inclusive, multi-disciplinary and multicultural organization with a 45+ year history of interventions toward enhancing Underrepresented Minority (URM) participation in STEM fields. The National Diversity in STEM Conference (Conference) aims at increasing preparedness of the scientific workforce by delivering a vanguard scientific program, provide a framework for research presentations, enable trans-disciplinary discussions, provide mentoring opportunities, and promote professional development of URMs in biomedically-focused and behaviorally-related STEM fields. The Conference will also encourage panel discussions on how we can best integrate and diversify biomedical research, paying particular attention to be inclusive of those most underserved and underrepresented (e.g. Native Americans).

PI_NAMEs: DAVILA-GARCIA, MARTHA ISABEL (contact);SILVEYRA, PATRICIA

PROGRAM_OFFICER_NAME: BROWN, ANISSA F

PROJECT_TERMS: Academia;Address;Administrator;Advocacy;Attention;Awareness;Behavioral;Behavioral Research;Behavioral Sciences;Biomedical Research;career;career development;Chronic;Collaborations;Communication;Communities;Country;Creativeness;Dedications;Development;Discipline;Education;Educational workshop;Ethnic Origin;Exposure to;Future;geographically distant;Goals;Government;graduate student;Growth;Health;Hispanic Americans;Human;Individual;Industry;Infrastructure;innovation;Intervention;Knowledge;Lead;Leadership;meetings;member;Mentors;Mexican Americans;Minority;Minority Participation;minority scientist;Mission;multidisciplinary;Native Americans;next generation;Organizational Culture;originality;Participant;Policies;Positioning Attribute;Postdoctoral Fellow;Program Development;programs;Readiness;Recording of previous events;Research;role model;Scholarship;Science;Science, Technology, Engineering and Mathematics;scientific organization;Scientist;Self Efficacy;Societies;STEM field;STEM research;Strategic Planning;student participation;Students;symposium;System;Talents;Travel;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underserved Population;volunteer;welfare;Work;World Health


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Underrepresented early career investigators need the opportunity to gain research knowledge coupled with quality mentorship to assist with the proper application of those skills, resulting in innovative and meaningful research. In addition to providing mentorship on research skills, it is also important to understand the circumstances, in which early career investigators have found themselves and work to develop needed soft (non- research) skills. Taken together, my philosophy as a mentor is to provide experiences for early career investigators, especially from underrepresented groups, that will help them develop into well-rounded individuals who contribute to advancing science as well as be demonstrative of reputable citizens in academe.

PI_NAMEs: SMALLS, BRITTANY L. (contact)

PROJECT_TERMS: Academia;Address;Awareness;Back;Behavior;career;career development;Career Mobility;clinical center;Clinical Sciences;community based research;Coupled;data management;Dedications;Descriptor;Development;Diverse Workforce;early experience;Educational workshop;Event;experience;Faculty;foot;Funding;Future;Goals;Grant;gratitude;Growth;Habits;health inequalities;Individual;innovation;Internships;Kentucky;knock-down;Knowledge;Leadership;Learning;man;meetings;member;Mentors;Mentorship;mid-career faculty;Minority Women;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Phase;Philosophy;Research;Research Design;Research Personnel;Resource Sharing;Resources;response;responsible research conduct;Rewards;Role;Science;Scientist;skills;social health determinants;success;Training;Translational Research;undergraduate research;Underrepresented Populations;Universities;Work

PROJECT_TITLE: Initiate Research, Opportunities, and Networks for Underrepresented Early Career Investigators (IRON)


ADMINISTERING_IC: EY

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: MADISON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE Contemporary research in visual sciences requires access to modern quantitative and analytical technologies, the use of a variety of complex animal models, and state-of-the-art imaging. This Vision Science Core proposal encompasses all of these requirements to augment the already exceptional research capabilities of investigators at the University of Wisconsin-Madison. A fundamental difference in this revised application is the expansion of our quantitative molecular biology core to include access to the “Omics” facilities that are operated by the UW campus. Our plan is to provide Core users with a subsidy to facilitate their use of these facilities, which includes modern high-throughput and multi-plexing sequencing technologies, mass spectroscopy (including lipidomics and metabolomics), and proteomics. Additionally, the core itself has added laser-capture microdissection instrumentation and plans to acquire a SeaHorse XF analyzer to augment these capabilities. The imaging core retains its services for top-tier histopathology, while including access to high resolution confocal and live-cell imaging and conventional electron microscopy. Additionally, this core has added access to a new serial block face scanning electron microscopic facility that is co-directed by Dr. Mrinalini Hoon who is also a co-director of this part of our core application. Lastly, we retain our animal model core to provide world class expertise and access to the variety of complex animal models and ex vivo systems, ranging from rodents to non-human primates, that are essential to translational discovery in vision research. As a new initiative, this core is also the center of a new biobank of human ocular tissue and fluids that is being cataloged, stored, and made available to core users for research projects.

PI_NAMEs: NICKELLS, ROBERT W (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Animal Model;biobank;Complex;Confocal Microscopy;Core Grant;Electron Microscopy;Electrons;Equipment;Eye;Eye diseases;Face;Family Felidae;Flow Cytometry;Fostering;Genus Hippocampus;Goals;Histopathology;Human;Image;Image Analysis;instrumentation;laser capture microdissection;light microscopy;lipidomics;Liquid substance;live cell imaging;Mass Spectrum Analysis;metabolomics;Methods;Microscopic;Modernization;Molecular;Molecular Biology;next generation sequencing;nonhuman primate;Organ Culture Techniques;Outcome Measure;Pathology;Proteomics;Research;Research Personnel;Research Project Grants;Resolution;Rodent;Scanning;Services;Stains;Structure;System;Technology;Tissue Stains;Tissues;transcriptome sequencing;Universities;Vision;Vision research;vision science;Visual;Wisconsin

PROJECT_TITLE: Core Grant for Vision Research


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Health Services;Neurosciences

PHR: ADMINISTRATIVE CORE NARRATIVE The goals of the Administrative Core are to provide for the smooth operation of the various cores to ensure that users receive timely and appropriate services from the Vision Research Core, to insure that users with qualifying NEI R01 grants receive priority service, to assist others carrying out vision related research, to assist vision researchers in developing preliminary data to support new applications, to enable user access to equipment in the core, to facilitate user access to other campus entities that support research (e.g. Biotechnology Center), and to adjudicate any potential disputes as to the quality and availability of services.

PROJECT_TERMS: adjudication;Biotechnology;Core Grant;Data;Disputes;Equipment;Goals;Grant;Health Services Accessibility;operation;Qualifying;Research;Research Personnel;Research Support;Services;Vision;Vision research

PROJECT_TITLE: Core Grant for Vision Research - Administrative Core


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences

PHR: CORE 1: OCULAR OMICS AND QUANTITATIVE MOLECULAR BIOLOGY NARRATIVE The goal of Core 1 is to provide the following services to users with qualifying grants and other vision researchers. The quantitative molecular biology services include providing consultation for and access to quantitative PCR, access to plate readers for quantitation of antibodies, cytokines, and other analytes, access to spectrophotometers and a bionalazyer for RNA, DNA and protein samples, a laser microdissection system to obtain material from tissue sections for transcriptomics, metabolomics, or proteomics analysis, allelic characterization of normal and genetically modified mice, nucleic acid probe design, in situ hybridization, quantitative reporter gene analysis. This core will also facilitate use of campus resources such as the Biotechnology Center (NextGen Sequencing, RNAseq, data handling and analysis, proteomics, etc.) and the Flow Cytometry Facility.

PI_NAMEs: IKEDA, AKIHIRO  (contact)

PROJECT_TERMS: Alleles;Antibodies;Biotechnology;Consultations;Core Grant;cytokine;Data Analyses;data handling;design;DNA;Flow Cytometry;Gene Modified;Goals;Grant;In Situ Hybridization;Lasers;metabolomics;Microdissection;Molecular Biology;Mus;next generation sequencing;Nucleic Acid Probes;Proteins;Proteomics;Qualifying;Reader;Reporter Genes;Research Personnel;Resources;RNA;Sampling;Services;Spectrophotometry;System;Tissues;transcriptome sequencing;transcriptomics;Vision;Vision research

PROJECT_TITLE: Core Grant for Vision Research - Core 1


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

PHR: CORE 2: PATHOLOGY AND IMAGING NARRATIVE The goal of the Pathology and Imaging core is to enable investigators to obtain state-of-the art imaging procedures to meet their research goals. Specifically, the module (1) provides tissue processing services for both light and electron microscopy, (2) provides access to state-of-the art imaging equipment located in institutional core facilities and in our Cores, (3) maintains image acquisition instruments and (4) trains eye and vision researchers on how to use and develop novel imaging technologies for their individual and collaborative research programs. It is also responsible for the collection and maintenance of tissue specimens and cell lines.

PI_NAMEs: PETERS, DONNA M (contact)

PROJECT_TERMS: Cell Line;Collection;Core Facility;Core Grant;Electron Microscopy;Equipment;equipment acquisition;Eye;Goals;Image;Imaging Techniques;Individual;Institution;light microscopy;Maintenance;novel imaging technology;Pathology;programs;Research;Research Personnel;Services;Specimen;tissue processing;Tissues;Training;Vision;Vision research

PROJECT_TITLE: Core Grant for Vision Research Core 2


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Infectious Diseases;Neurodegenerative;Neurosciences

PHR: CORE 3: ANIMAL MODELS AND EYE ORGAN CULTURE NARRATIVE The goal of the Animal Models and Eye Organ Culture Core is to facilitate the use of animals and eye organ culture to study visual function and visual diseases by qualifying NEI funded researchers. We also assist non- qualifying investigators in generating preliminary data, in support of proposals seeking NIH funding. This is accomplished by providing expertise in complementary animal models across a range of species from rodents to non-human primates (NHPs) and including spontaneous and experimental models of glaucoma, retinal degeneration, ocular vascular disease ocular pharmacology and toxicology and infectious diseases and includes animal handling and anesthesia and, importantly, provision of alternatives to live animal research including eye organ culture. We provide expertise and equipment necessary for the evaluation of visual system structure and function including ERG, multifocal and pattern ERG, VEP, OCT, retinal imaging, tonometry and outflow facility and outflow pathway determination. As a result of unique expertise and access to model species spanning the translational spectrum, this core has had a broad impact, facilitating interdisciplinary and inter-institutional vision research in support of the NEI’s mission.

PI_NAMEs: MCDOWELL, COLLEEN MARY (contact)

PROJECT_TERMS: Anesthesia procedures;Animal Experimentation;Animal Model;Animals;Communicable Diseases;Core Grant;Data;Disease;Equipment;Evaluation;Experimental Models;Eye;Eye diseases;Funding;Glaucoma;Goals;inter-institutional;Mission;Modeling;nonhuman primate;Organ Culture Techniques;Pathway interactions;Pattern;Pharmacology and Toxicology;Qualifying;Research Personnel;Retinal Degeneration;retinal imaging;Rodent;Structure;tonometry;translational pipeline;United States National Institutes of Health;Vascular Diseases;Vision;Vision research;Visual;Visual System

PROJECT_TITLE: Core Grant for Vision Research - Core 3


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: This Career Development Award (CDA)-2 proposal will offer comprehensive training in psychiatric genetics for Dr. Peter Na to advance his research skills to become an independent VA researcher. The proposed research project will investigate environmental (e.g., adverse childhood experiences), and psychosocial (e.g., purpose in life, social support) (EP) factors that moderate the genetic liability for substance use disorders (SUDs) in Veterans using polygenic risk scores derived from large genome-wide association studies (GWAS). Further, the proposed study will advance our understanding of the biopsychosocial etiology of SUDs using cutting-edge genetic research methodologies such as epigenetic, gene enrichment and drug-repositioning analyses. The moderating EP factors identified in the study will elucidate targets for clinical interventions to prevent and treat SUDs in Veterans and ultimately help guide VHA clinical practices.

PI_NAMEs: NA, PETER  (contact)

PROJECT_TERMS: addiction;Address;adverse childhood events;Affect;Alcohol consumption;alcohol use disorder;Animals;Area;Award;Biological;Biological Process;biopsychosocial;candidate identification;career;Childhood;Chronic;Clinical;clinical practice;Clinical Research;Cocaine use disorder;cohort;Data;Data Set;Disabling;Disease;disorder risk;DNA Methylation;drug repurposing;Drug usage;Drug Use Disorder;Education;Educational workshop;Environmental Risk Factor;Epidemiology;Epigenetic Process;Etiology;experience;follow-up;functional genomics;Genes;Genetic;Genetic Research;Genetic Risk;genetic variant;genome wide association study;genome-wide;Grant;Health;healthcare burden;Institution;Intervention;K-Series Research Career Programs;Knowledge;large datasets;Life;Literature;Longitudinal cohort;Machine Learning;marijuana use disorder;Measures;Mentors;Mentorship;Methods;military veteran;Molecular;novel therapeutics;opioid use disorder;optimism;Personality Character;Pharmaceutical Preparations;Phenotype;Pilot Projects;polygenic risk score;precision medicine;Predisposition;prevent;Prevention;Process;programs;protective factors;Psychiatric epidemiology;psychiatric genomics;Psychiatrist;psychogenetics;psychosocial;Psychosocial Factor;Public Health;Research;Research Methodology;Research Personnel;Research Priority;Research Project Grants;resilience;Risk;Risk Factors;Role;Sampling;skills;Social support;statistics;Structure;substance use;Substance Use Disorder;Testing;Training;training project;Transition Career Development Award (K22);Universities;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Understanding the role of modifiable environmental and psychosocial factors in moderating genetic risk for substance use disorders in Veterans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURA-U (01)]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: OXFORD

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY OF OXFORD

ORG_ZIPCODE: OX1 2JD

PHR: Title: Correlative cryoET of the HIV-1 integration targeting in native T-lymphocytes Project Narrative HIV-1 infection remains a global health concern. While the past 30 years have seen a dramatic increase in the life expectancy of individuals living with HIV, however, there is still no reliable treatment to eradicate HIV-1 from its human host and no vaccine to protect the society from new infections. One of the reasons underlying the persistence of HIV-1 is its permanent integration into the host’s genome, where the structure of chromatin plays a pivotal role. Understanding chromatin architecture of HIV-1 integration targeting and the interplay between HIV-1 and host chromatin hold the promise of informing strategies to disrupt latent infections and aid in the development of innovative therapies targeting the viral-host interface.

PI_NAMEs: ZHANG, PEIJUN  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Active Sites;Address;Architecture;Biochemical;Capsid;Capsid Proteins;Cell Line;Cell membrane;Cell Nucleus;Cells;Chromatin;Chromatin Fiber;Chromatin Structure;chronic infection;Cleavage And Polyadenylation Specificity Factor;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cofactor;Complex;Cytoplasm;Data;Development;DNA;DNA Integration;Electrons;Fluorescence;Gene Expression;Genes;Genetic;Genetic Materials;Genetic Transcription;Genome;global health;Growth Factor;HIV;HIV-1;Human;imaging study;Immune system;Immunologic Surveillance;In Situ;in situ imaging;Individual;Infection;Innovative Therapy;insight;Integrase;Integration Host Factors;integration site;Ions;Jurkat Cells;Knock-in;Knock-out;Knowledge;Label;latent infection;lens epithelium-derived growth factor;Life Expectancy;Methodology;Molecular;mutant;Mutation;novel;Nuclear;Nuclear Pore;nucleocytoplasmic transport;Nucleosomes;particle;Pathogenesis;Play;Positioning Attribute;Proteins;Quantum Dots;Research;Resolution;Retroviridae;Reverse Transcription;RNA-Directed DNA Polymerase;Role;Rupture;Signal Transduction;Site;Societies;stable cell line;structural biology;Structure;T-Lymphocyte;targeted treatment;Technology;Tetanus Helper Peptide;trafficking;transcriptional coactivator p75;Vaccines;Viral;viral DNA;Viral Genes;Viral Genome;viral RNA;Virion;Virus Integration;Virus Replication;Visualization

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Data Science;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Primary Health Care;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE The project proposes to develop an HIV risk prediction model (ACTION-HIV algorithm) that can detect women with a higher risk of HIV and translate the ACTION-HIV algorithm into a clinical decision support (CDS) platform integrated into an electronic health record (EHR) system to assess its feasibility, acceptability, and usability. This is a major step toward overcoming the gaps in existing HIV risk prediction algorithms and helping providers identify women for HIV testing and pre-exposure prophylaxis (PrEP). Our innovative EHR- based CDS tool is relevant to public health as it can have a potentially significant impact on increasing HIV testing, reducing sex disparity in PrEP uptake, and decreasing new HIV infection in Florida.

PI_NAMEs: CHO, HWAYOUNG ;LIU, YIYANG  (contact)

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: AIDS prevention;Algorithms;Ambulatory Care Facilities;Architecture;candidate identification;Caring;Classification;Clinical;Clinical assessments;clinical decision support;clinical implementation;clinical predictors;Clinical Trials;clinically relevant;Communicable Diseases;community-level factor;Data;Data Scientist;Data Set;Decision Making;design;Development;Electronic Health Record;electronic health record system;electronic structure;Eligibility Determination;Ensure;Environment;Epidemic;Epidemiologist;Florida;Focus Groups;Future;Goals;Health;Health Personnel;Health Services;high risk;High Risk Woman;HIV;HIV Infections;HIV risk;Human immunodeficiency virus test;implementation science;improved;Incidence;innovation;insight;Intervention;Link;Machine Learning;machine learning method;machine learning prediction;male;Measures;men;Modeling;Natural Language Processing;Newly Diagnosed;Outpatients;Participant;Patient-Focused Outcomes;Patients;Persons;pilot test;point of care;pre-exposure prophylaxis;predictive modeling;predictive tools;prevent;prevention service;Prevention strategy;primary care clinic;primary care provider;primary care setting;Primary Health Care;Production;Protocols documentation;prototype;Provider;Public Health;public health relevance;Reporting;repository;Research;Research Personnel;Rights;Risk;Risk Factors;risk prediction;risk prediction model;Scientist;screening;Services;sex disparity;skills;social health determinants;support tools;Surveys;System;Testing;Time;Translating;transmission process;Trust;uptake;usability;user centered design;Woman

PROJECT_TITLE: AI-based Clinical decision support to idenTify wOmeN for HIV testing and PrEP in Florida (ACTION-HIV)

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: NARRATIVE One major goal of human genetics is to understand the functional consequences of the various genetic and chromosomal variation that exists within a population. Telomeres are crucial chromosomal structures that protect chromosome ends from instability and length of the telomere can highly vary between individuals in many organisms, including humans. This proposal uses plants as a tractable model to uncover the molecular function and evolutionary significance of telomere length variation within populations.

PI_NAMEs: CHOI, JAE YOUNG  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Affect;Aging;aging related disease;Animals;Automobile Driving;Biological;cellular development;Chromosome Structures;Chromosomes;Development;Disease;DNA;Eukaryota;Evolution;fitness;Flowers;Genes;Genetic;genetic variant;Genomic Instability;Goals;Growth;Human;Human Genetics;Individual;Knowledge;Length;life history;Link;Mimulus;Modeling;Molecular;novel;Organism;Plants;Pluripotent Stem Cells;Population;Predisposition;protein complex;Regulation;reproductive;Research;Role;Shapes;stem cell differentiation;stem cells;System;telomere;Testing;Time;trait;tumorigenesis;Variant;Whole Organism;Work

PROJECT_TITLE: Molecular mechanisms and evolution of natural telomeric variation

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative This mixed-methods sequential exploratory/developmental study, which is guided by the NIMHD research framework adapted for sexual and gender minority health research, is relevant to public health for several reasons. The study will (a) describe how social ecological factors facilitate or impede sexual risk, HIV testing, and PrEP use among Latino/x sexual minority men (SMM) migrants, (b) investigate the role of social integration factors (immigration status, length of time in the U.S., language use, social connections, healthcare access and utilization) in the association between social ecological factors and sexual risk, HIV testing, and PrEP use among Latino/x SMM migrants, and (c) illustrate sexual risk, HIV testing, and PrEP decision-making processes as it relates to PrEP use disparities among Latino/x SMM migrants. This research will further establish the empirical foundation for future research with this exceptionally vulnerable subgroup of Latino/x, SMM, and migrant populations; that is, a longitudinal examination of PrEP uptake and promotion.

PI_NAMEs: ALESSI, EDWARD J (contact);ROBLES ALBERTO, GABRIEL

PROGRAM_OFFICER_NAME: GARRIDO, CARLOS OSWALDO

PROJECT_TERMS: Address;AIDS prevention;Attention;Behavior;Communities;cultural values;Data;Data Collection;Decision Making;Development;Disparity;District of Columbia;Economics;Education;Employment;Epidemic;experience;Formulation;Foundations;gender minority health research;Health;health care availability;health care service utilization;Health Disparities Research;health disparity;high risk;Hispanic;HIV;HIV Infections;Housing;Human immunodeficiency virus test;Immigration;improved;Individual;Intervention;Interview;Language;Latino;Length;Link;male;men;Methods;Migrant;migration;minority health disparity;National Institute on Minority Health and Health Disparities;neglect;Nonmigrant;Phase;pilot test;Population;pre-exposure prophylaxis;prevent;Prevention;Process;protocol development;Public Health;recruit;Research;Research Design;Research Personnel;Risk;Role;Sampling;Science;Sex Orientation;Sexual and Gender Minorities;sexual minority;sexual minority group;sexual minority men;Sexual Transmission;Shapes;social;social culture;social integration;social structure;Social support;Spanish;structural determinants;Subgroup;Surveys;therapy design;Time;transmission process;uptake;Victimization

PROJECT_TITLE: A Mixed-Methods Study of the Social Ecological and Integration Factors Associated with HIV Prevention Behaviors Among Latino/x Sexual Minority Migrant Men in the U.S.

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: NARRATIVE This study will enhance our understanding of the utilization of multiple evidence-based approaches for HIV risk reduction among rural people who inject drugs (PWID) and afford new insights about how to best meet HIV prevention needs. Our study will fill an important gap in the scientific literature as we will examine how complex patterns of initiation and sustained utilization of multiple risk reduction strategies are associated with network characteristics and change over time. This study will inform the adaptation of an evidence-based intervention for reducing HIV risks among PWID to a rural context.

PI_NAMEs: ALLEN, SEAN T (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;AIDS prevention;Area;Characteristics;cohort;Complex;County;Cross-Sectional Studies;Data Analyses;density;Disadvantaged;Disease Outbreaks;Drug usage;Equipment;evidence base;Evidence based intervention;experience;Frequencies;Glean;Goals;Harm Reduction;high risk;high risk behavior;high risk sexual behavior;HIV;HIV diagnosis;HIV risk;Incidence;Individual;Injecting drug user;injection drug use;Injections;innovation;insight;Intervention;Law Enforcement;Link;Literature;longitudinal analysis;Longitudinal cohort study;Maps;medication for opioid use disorder;National Institute of Drug Abuse;Needle Sharing;Needle-Exchange Programs;Pattern;pilot test;Population;pre-exposure prophylaxis;Prevention Research;preventive intervention;Process;Randomized, Controlled Trials;Reduce health disparities;Research;Research Design;Risk Behaviors;Risk Reduction;Rural;Rural Community;rural counties;Rural Population;Science;service programs;Sex Behavior;social influence;Social Network;social norm;social relationships;Sterility;stimulant use;Strategic Planning;substance use;therapy design;Time;transmission process;United States;Unsafe Sex;urban area;Urban Population;West Virginia

PROJECT_TITLE: Adapting a Network-Oriented HIV Prevention Intervention for Rural People Who Inject Drugs (PWID)