ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative Lung cancer is the most commonly diagnosed and deadliest cancer in the world, accounting for over nearly one-fifth of all cancer deaths in 2018 and the 5-year survival rate for non-small cell lung cancer (NSCLC) is only 18.1%. The current proposal will focus on the link between cancer redox metabolism and DNA damage repair/signaling as a means to provide a mechanistic understanding of metabolic vulnerabilities of tumors with the goal of enhancing tumor cell responses to radio-chemotherapies. Overall, I believe that this F99/K00 award will provide the means for me to utilize my skills as a redox biologist in order to establish a research career focused on cancer cell redox metabolism and DNA damage repair/signaling in tumor cell responses to radio- chemotherapies.

PI_NAMEs: HEER, COLLIN DAVID (contact)

PROJECT_TERMS: Accounting;Adenosine;antioxidant enzyme;ataxia telangiectasia mutated protein;Award;Biology;Biomedical Research;cancer cell;career;Cell Death;Cells;Cessation of life;chemoradiation;chemosensitizing agent;chemotherapy;Complex;cytotoxic;Data;Defect;Diagnosis;DNA;DNA Damage;DNA Repair;Doctor of Philosophy;Effectiveness;Enzymes;Exhibits;experience;Faculty;Glucose;glucose uptake;Glutathione;Goals;Hydrogen Peroxide;inhibitor;inorganic phosphate;Institution;interest;Investigation;Knowledge;Link;lung cancer cell;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Metabolic;metabolic phenotype;Metabolism;Modality;NADP;neoplastic cell;nicotinamide phosphoribosyltransferase;Non-Small-Cell Lung Carcinoma;Normal Cell;novel therapeutic intervention;Operative Surgical Procedures;Outcome;overexpression;Oxidation-Reduction;Oxidative Stress;Pathway interactions;Pentosephosphate Pathway;pharmacologic;Phase;Poly(ADP-ribose) Polymerases;Polymers;Positioning Attribute;Postdoctoral Fellow;Pre-Clinical Model;Property;Radiation therapy;Radio;Radiosensitization;Reactive Oxygen Species;repaired;Research;Research Personnel;Research Project Grants;response;Ribose;Role;Signal Pathway;Signal Transduction;skills;Source;Survival Rate;System;Toxic effect;Training;tumor;tumor metabolism;TXN gene;Work

PROJECT_TITLE: Elucidating and exploiting NAD metabolic defects in cancer


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: AUSTIN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Public health relevance Human birth defects and many cancer types originate from failure of cells to establish proper polarity. Results from this proposal will address how cell cycle kinases couple the cell cycle with polarity establishment, which is crucial in asymmetric cell division and ultimately development. Additionally, this work will also provide information that might be co-opted to develop therapeutic strategies to treat birth defects.

PI_NAMEs: MANZI, NADIA INGABIRE (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Affect;Apical;Arthropods;Binding;Biochemical;Caenorhabditis elegans;cancer type;Cell Cycle;Cell Cycle Stage;Cell division;Cell Polarity;Cell Separation;cell type;Cells;Centrosome;Complex;Congenital Abnormality;Coupled;Data;daughter cell;Defect;Development;dimer;Embryo;Ensure;Event;Exhibits;experimental study;Failure;genome editing;Human;Image;inhibitor;insight;Knowledge;Light;Location;Malignant Neoplasms;Measures;Meiosis;Microscopy;mimetics;Mitosis;Modeling;Molecular;Mouse Embryonic Stem Cells;mutant;Mutation;Nematoda;optogenetics;Organism;Phenotype;Phosphorylation;Phosphorylation Site;Phosphotransferases;Photoreceptors;polarized cell;Positioning Attribute;protein complex;Protein Dynamics;protein protein interaction;Proteins;public health relevance;recruit;Regulation;Resolution;RNA Interference;Role;segregation;Signal Transduction;single molecule;Site;stem cells;System;Testing;Therapeutic;Tissues;transmission process;Work;zygote

PROJECT_TITLE: How a cell cycle kinase, Aurora A, regulates polarity proteins organization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-U(20)L]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Autophagy-mediated host defenses are important for controlling viral replication and virus- induced pathogenesis. This study will provide new molecular insight into the mechanisms by which autophagy controls viral infection, which may catalyze the design of broad-spectrum antiviral agents.

PI_NAMEs: GACK, MICHAELA ULRIKE (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Amino Acid Motifs;Anti-viral Agents;Anti-viral Response;antimicrobial;antiviral drug development;antiviral immunity;Autophagocytosis;Autophagosome;Binding;Biochemical;Biological;Biological Process;C-terminal;Cell Culture System;cell type;Cells;cytokine;Cytokine Signaling;Data;Defense Mechanisms;design;Development;Family member;Foundations;Gene Targeting;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Herpesvirus 1;Host Defense;Host resistance;Hydrolysis;Immune;Immune signaling;Immunity;In Vitro;in vivo;Infection;insight;Interferons;Knockout Mice;Knowledge;Laboratories;Link;Lysosomes;Mediating;Microbiology;Molecular;mouse model;mutant;N-terminal;Natural Immunity;Nature;Nerve Degeneration;Organelles;pathogen;Pathogenesis;pathogenic virus;Pathway interactions;Phosphorylation;Phosphotransferases;Physiological;Play;Polyubiquitin;Process;Protein Family;Proteins;rational design;receptor;Regulation;response;Role;Series;TBK1 gene;Testing;TRIM Motif;Ubiquitin C;ubiquitin-protein ligase;Ubiquitination;upstream kinase;Viral;Viral Pathogenesis;Viral Physiology;viral resistance;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: The Role of TRIM23 in Autophagy Mediated Antiviral Defenses

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Infectious Diseases;Pediatric

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: NARRATIVE Academic researchers with a focus on infectious diseases have contributed to the elimination, prevention and control of diverse infections that cause substantial morbidity and mortality in children, including smallpox, polio, meningitis, measles, malaria, diarrhea, and AIDS. Despite substantial progress, both long-standing (e.g., diarrheal illnesses) and emerging infectious diseases (e.g., SARS-CoV-2) continue as leading causes of death and disability to children in the US and globally, especially among children under 5 years of age. The goal of this proposal is to train committed individuals to perform needed and groundbreaking research on the prevention and treatment of infections that afflict children, and to enable these researchers to focus their careers on improving the health of children everywhere.

PI_NAMEs: URDAHL, KEVIN B (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Childhood;Communicable Diseases

PROJECT_TITLE: Academic Pediatric Infectious Disease


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative There is a critical need for safe and effective therapies to stimulate bone formation in diabetic patients with osteoporosis. This proposal builds upon recent discoveries by us and others about bone cell metabolism, and will examine in detail the potential dysregulation of cellular metabolism caused by diabetes. Promising results from this study may open a new avenue for developing bone-enhancing drugs.

PI_NAMEs: LONG, FANXIN  (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Adult;Anabolic Agents;Apoptosis;Area;Biochemical Markers;bisphosphonate;Black Box;bone;bone cell;Bone Formation Stimulation;bone fracture repair;bone fragility;Bone Growth;bone healing;bone mass;bone quality;bone turnover;Carbon;cardiovascular risk factor;Cell Lineage;Cells;Cellular Metabolic Process;Child;Childhood;Childhood diabetes;Citric Acid Cycle;Clinical;Consumption;Coupled;Data;Defect;design;Deterioration;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;differentiation in vitro;disease model;Down-Regulation;Doxycycline;effective therapy;Energy Metabolism;Energy-Generating Resources;fatty acid metabolism;Fatty Acids;Forteo;Foundations;fracture risk;Galactose;Genes;Glucose;glucose metabolism;Glutamine;Glycolysis;Impairment;In Vitro;in vivo;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Knowledge;Label;Link;long bone;Metabolic;metabolic profile;Metabolism;Modeling;mouse model;Mus;Newly Diagnosed;next generation;novel;Oleates;osteoblast differentiation;Osteoblasts;Osteoclasts;Osteogenesis;Osteoporosis;Osteosarcoma;Oxidative Phosphorylation;Patients;pediatric patients;Periosteal Cell;Periosteum;Pharmaceutical Preparations;Phenotype;Point Mutation;Positioning Attribute;postnatal;Potential Energy;Predisposition;Prevention;rational design;Regulation;Research;Role;Serum;single-cell RNA sequencing;Solid;stem cell differentiation;Structure of beta Cell of islet;Testing;type I and type II diabetes;warning label

PROJECT_TITLE: The cell metabolism basis for bone complications in type I diabetes


ADMINISTERING_IC: MD

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: 8. Project Narrative  Despite two decades of improvement in quality of end of life care, racial and ethnic disparities remain. Implicit, or unconscious racial bias may influence how physicians communicate with patients about their end of life care preferences, and thus effect quality of end of life care. Understanding how to mitigate the effects of physician implicit bias is critical to reduce racial and ethnic disparities in end of life care, and this knowledge is likely to have implications in other clinical settings.

PI_NAMEs: CHUANG, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Address;Adult;Affect;Applications Grants;Area;arm;Asian;Attitude;Award;Belief;Black American;black patient;Black race;care preference;career;Caregivers;Caring;Clinical;clinical care;clinical investigation;Clinical Trials;Code;Communication;communication behavior;community engaged research;Critical Illness;design;Disparity;disparity reduction;distrust;Educational Intervention;Effectiveness of Interventions;effectiveness testing;Elements;end of life;end of life care;end-of-life communication;Enrollment;ethnic disparity;ethnic diversity;evidence base;experience;Failure;Family;Family Caregiver;Family Study;feasibility testing;Feedback;Focus Groups;Foundations;Funding;Goals;Group Interviews;health care disparity;health care service utilization;health care settings;health disparity;Healthcare;Hospice Care;hospice environment;Implicit Association Test;implicit bias;improved;Instruction;Intervention;Investigation;Knowledge;Link;marginalization;Measures;Mentors;Methods;Minority Groups;Modeling;Needs Assessment;Nonverbal Communication;Outcome;Palliative Care;Participant;patient oriented;Patient Preferences;patient-clinician communication;Patients;Pattern;Physicians;Population;preference;Prognosis;provider communication;Questionnaires;Race;racial bias;racial disparity;racial diversity;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Regrets;Reporting;Research;Research Personnel;Research Training;Resistance;Services;simulation;Site;skills;skills training;Stereotyping;Techniques;Testing;tool;Training;Trauma;Trust;Unconscious State;United States;Urban Community;Urban Hospitals;verbal;Videotape;Work

PROJECT_TITLE: Targeting Bias to Reduce Disparities in End of Life Care (BRiDgE)


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: Public Health Statement Vision science seeks to understand how the visual system functions and aims to develop treatments for visual pathologies. The proposed studies to investigate the processing of visual uncertainty in cortex and its role in perception will provide rigorous steps towards those goals. The obtained knowledge may help to advance the treatment of cortical-based visual pathologies such as agnosia, dyslexia, and amblyopia.

PI_NAMEs: GORIS, ROBBE L (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Afferent Neurons;Agnosia;Amblyopia;Animals;Area;area striata;area V1;autism spectrum disorder;awake;Bayesian Analysis;Behavior;Behavioral;Behavioral Paradigm;Brain;Code;Cognition;Communication;computerized tools;Cues;Data;Decision Making;Development;Dyslexia;Environment;experience;Foundations;Goals;Human;Knowledge;Macaca;Measures;Memory;Modeling;Monkeys;Nature;neural;neural circuit;neural correlate;Neurons;Noise;novel;orientation selectivity;Outcome;Pathology;Perception;Population;Prefrontal Cortex;Primates;Probability;Process;Property;Public Health;Reporting;response;Role;Saccades;sample fixation;Sampling;Schizophrenia;Sensory;sensory input;sensory integration;Sensory Process;Shapes;Signal Transduction;Stimulus;Surveys;System;Testing;theories;Uncertainty;V1 neuron;vision science;Visual;Visual Cortex;visual information;visual processing;Visual System;Volatilization;willingness;Work

PROJECT_TITLE: Uncertainty, inference, and introspection in the primate visual system

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Emerging adults have particularly unhealthy dietary habits, increasing their risk for obesity and cardiovascular disease. Communicating about the health and environmental impacts of food could motivate emerging adults to adopt healthier diets, but this promising and highly scalable strategy has not been rigorously evaluated. The proposed research will develop health and environmental messages about food and evaluate messages’ impacts on the healthfulness of emerging adults’ food purchases.

PI_NAMEs: GRUMMON, ANNA H (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Address;Adopted;Adult;advanced analytics;Age;age group;Animals;Area;Award;bean;beef;Behavioral Sciences;carbon emissions;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;career;Cessation of life;Communication;Communication Research;Consumption;Data;Databases;design;Development;Diet;Diet Habits;dietary;Dietary intake;Dietary Practices;Eating Behavior;Educational workshop;Effectiveness;emerging adult;emerging adulthood;Environmental Health;Environmental Impact;Environmental Risk Factor;experience;experimental study;Fabaceae;Focus Groups;Food;food consumption;Fruit;Funding;Future;Goals;good diet;greenhouse gases;hands on research;Health;health communication;Healthy Eating;improved;indexing;Individual;interest;Intervention;Link;Longitudinal Studies;Mentors;Mentorship;Methods;mortality;National Health and Nutrition Examination Survey;National Heart, Lung, and Blood Institute;novel;Nutrition Policy;Nutritional Study;Obesity;obesity risk;older adult;Outcome;Participant;Plants;prevent;preventive intervention;Processed Meats;Product Labeling;Public Health Schools;Quasi-experiment;Randomized;randomized trial;Randomized, Controlled Trials;rapid weight gain;Reaction;Recommendation;Reporting;Research;Research Activity;Research Personnel;Risk;social media;social norm;symposium;Techniques;Testing;Time;Training;Translating;Unhealthy Diet;United States National Institutes of Health;Universities;Vegetables;Workplace

PROJECT_TITLE: Developing and Evaluating Health and Environmental Messages to Improve Diet in Emerging Adults

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative Increases in computational power and data availability have facilitated development of advanced statistical methods and artificial intelligence (AI) technologies, powerful tools for knowledge discovery and facilitating clinical decision making, but have also made evident the existence of biases and blind spots, both implicit and explicit, in both data and models. As such, fairness, interpretability, and reproducibility are among several emerging areas in need of research both in computer science and biomedical informatics. This project will focus on developing a novel fairness metric and new machine learning techniques for real-time clinical decision support in the critical care and ICU settings to address issues of health diversity, equity, and inclusion through the use of fair machine learning algorithms to appropriately handle missingness and bias in clinical data.

PI_NAMEs: HONG, PENGYU ;ZHOU, LI  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Address;Advanced Development;Algorithms;Area;Artificial Intelligence;Attention;Awareness;Big Data;biomedical informatics;Characteristics;Chronic;Clinical Data;clinical decision support;clinical decision-making;clinical practice;Collaborations;Complex;computer science;Critical Care;Data;Data Set;Decision Making;deep learning;design;Development;Effectiveness;Electronic Health Record;Ensure;equity, diversity, and inclusion;Evaluation;Evaluation Methodology;explainable machine learning;Gender;Goals;Health;health care delivery;health data;health equity;Health Personnel;Healthcare;Healthcare Systems;Hospitals;improved;innovation;Insurance;Intensive Care Units;Knowledge Discovery;large datasets;Life;Machine Learning;machine learning algorithm;machine learning method;machine learning model;Massachusetts;Measurement;Medical Informatics;Medicine;Methods;Modeling;multimodality;novel;open source;outcome prediction;Patients;Performance;predict clinical outcome;predictive modeling;Prevalence;Process;Race;Reproducibility;Research;Retinal blind spot;Risk Factors;Statistical Methods;success;Techniques;Technology;Time;tool;Training;Training Technics;Visualization;Work

PROJECT_TITLE: Identifying and addressing missingness and bias to enhance discovery from multimodal health data

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Natural Products

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PI_NAMEs: VAN DER DONK, WILFRED A. (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Amino Acids;Anabolism;anti-fungal agents;Antibiotic Resistance;Antibiotics;antimicrobial;Biological;crosslink;Cyclic Peptides;Engineering;Enzymes;Etiology;Family;fighting;Future;Gene Cluster;Generations;Genome;genome sequencing;Goals;human disease;Human Microbiome;improved;Individual;Instruction;Investigation;Libraries;Life;Methods;Mining;Multienzyme Complexes;Natural Products;novel;Pathway interactions;peptide A;Peptides;Post-Translational Protein Processing;Prevention;Process;protein protein interaction;Research;Ribosomes;Route;Technology;thioether;tool;Viral;Work

PROJECT_TITLE: Posttranslational Modifications during Natural Product Biosynthesis

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: COLLEGE PARK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE Protein synthesis is a major pathway targeted by antibiotics, and the rise of multi-drug resistant bacteria calls for further understanding of the translational machinery to improve current antimicrobial treatment. Escherichia coli and Salmonella enterica cause over a million illnesses and tens of thousands of hospitalizations annually in the United States alone. Our work will provide insights into adaptation of such bacterial pathogens during stress conditions and facilitate development of novel antimicrobial strategies.

PI_NAMEs: LING, JIQIANG  (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Affect;Amino Acids;Antibiotics;antimicrobial;Bacteria;Behavior;Cells;Cues;Defect;Development;environmental change;Escherichia coli;fitness;Genetic;genetic information;Growth;Hospitalization;Impairment;improved;Individual;insight;interest;Laboratories;Mammals;Messenger RNA;Motility;Multiple Bacterial Drug Resistance;Nerve Degeneration;new technology;novel;pathogenic bacteria;Pathway interactions;Physiological;Population;Process;Protein Biosynthesis;Proteins;Quality Control;Regulation;Reporter;Research;response;Role;Salmonella;Salmonella enterica;Stress;System;Terminator Codon;translational genetics;United States;virulence gene;Work

PROJECT_TITLE: Regulation and Physiological Roles of Translational Fidelity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Health Services;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: PROJECT NARRATIVE This study will provide experimental evidence about the indirect and long run effects of maternal incentives.

PI_NAMEs: OKEKE, EDWARD N (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Age;Area;arm;Behavior;Birth;Budgets;Censuses;Cessation of life;Child;Child Health;Child health care;Child Mortality;Childhood;Cluster randomized trial;Communities;Country;Data;design;Developing Countries;Enrollment;fetal loss;financial incentive;follow-up;Friends;Future;Gifts;Health;Health Benefit;Health care facility;health care service;health service use;Health Services;Healthcare;improved;Incentives;indexing;Individual;innovation;interest;Intervention;intervention effect;Investments;Lead;Literature;Long-Term Effects;low and middle-income countries;Maternal and Child Health;Maternal Behavior;Maternal Mortality;Measures;mortality;Mothers;Neonatal Mortality;Nigeria;Outcome;payment;Perinatal Care;perinatal period;Play;Policies;Policy Maker;Population;postnatal;Postnatal Care;pregnant;Pregnant Women;prenatal;Prenatal care;programs;Quality of Care;Randomized;randomized trial;recruit;response;Role;Running;Side;stillbirth;Time;treatment arm;uptake;Visit;Woman;World Health Organization

PROJECT_TITLE: Long Term Effects of an Intervention on maternal behavior, child health, and community influence

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TAMPA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The proposed research will characterize genome-scale patterns of DNA methylation and gene expression in blood samples from African American participants in the Detroit Neighborhood Health Study, a population-based study of mental disorders among adult Detroit residents. Analyses will target brain-related epigenetic variation, measured in blood, and will test the effects of social context, both positive and negative, on DNA methylation and gene expression levels, and their relation to risk for post-traumatic stress disorder. Results from this study will provide a deeper characterization of how social exposures, both positive and negative, influence brain-related epigenomic processes to impact stress-related psychopathology among Africa Americans, an under-studied U.S. minority group with substantial health disparities in traumatic-stress related psychopathology.

PI_NAMEs: AIELLO, ALLISON E;UDDIN, MONICA  (contact);WILDMAN, DEREK

PROGRAM_OFFICER_NAME: MARTIN, IMAN

PROJECT_TERMS: Address;Adult;Affect;Africa;African American;African American population;age acceleration;American;Autopsy;Award;Biological;Biological Models;Blood;Blood specimen;Brain;Buffers;caucasian American;Cell Line;Central Nervous System;cohort;Cohort Studies;Communities;Data;Data Set;Discrimination;Disease Outcome;DNA Methylation;Emotional;Environment;Epigenetic Process;epigenetic variation;epigenomics;ethnic disparity;Exposure to;Funding;Gene Expression;gene regulatory network;genome-wide;genomic data;Glucocorticoid Receptor;Goals;Health;health disparity;high risk;insight;interest;Joints;Link;Loneliness;maltreatment;Measures;Mediating;Mental disorders;Mental Health;MicroRNAs;Minority Groups;mortality risk;Neighborhoods;Organ;Participant;Patients;Pattern;perceived discrimination;Peripheral;Play;Population Study;Post-Traumatic Stress Disorders;Process;prospective;Psychopathology;psychosocial;psychosocial resources;racial disparity;Research;response;Risk;risk mitigation;Role;Sampling;Science;Severities;Shapes;social;social adversity;social cohesion;Social Environment;social stress;Social support;socioenvironmental factor;Stress;Surveys;Symptoms;Testing;Tissues;Trauma;trauma exposure;traumatic stress;urban dwelling;Variant;Whole Blood;Work

PROJECT_TITLE: Epigenomic Predictors of PTSD and Traumatic Stress in an African American Cohort


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: CORVALLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Our training program has an exemplary record of accomplishment for training the next generation of scientists for impactful careers in environmental health sciences and public health. Trainees completing our transdisciplinary program are employed in academic, regulatory, commercial, and non-profit sectors to address current and emerging NIEHS research priorities and solve complex, real-world environmental problems to improve human and environmental health.

PI_NAMEs: KOLLURI, SIVA KUMAR;MARCUS, CRAIG B (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Environmental Health;Training Programs

PROJECT_TITLE: Integrated Regional Training Program in Environmental Health Sciences

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(T)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Depression causes serious difficulties with everyday functioning. For the 20 to 50% of depressed patients who fail to respond adequately to medications and psychotherapy, repetitive pulse transcranial magnetic stimulation (rTMS) is an important treatment alternative. RTMS benefit depends on placing the TMS coil in the correct place on the head to reach critical brain regions below. Several researchers, including our lab, showed that for a third of patients, the standard clinical practice used to determine coil placement location did not position it above the correct brain region, and patients failed to respond. We propose to test the accuracy of a different method of locating the coil placement on the head, called Beam F3. We will use functional MRI to identify brain regions predicted to improve functional outcomes in depressed Veterans (at Palo Alto VA) and also test whether accurate stimulation leads to better functional outcomes in patients undergoing rTMS therapy (at Providence VA). If successful, results will support improved patient outcomes.

PI_NAMEs: ROSEN, ALLYSON C (contact)

PROJECT_TERMS: Address;Adopted;alternative treatment;Area;Autopsy;biomarker identification;Brain;Brain region;Clinic;Clinical;clinical practice;Clinical Trials;clinically significant;cognitive control;Collaborations;cost;Cranial Nerves;Data;Depressed mood;depressed patient;detection limit;Diagnosis;Disease remission;distraction;Effectiveness;Electrodes;Electroencephalography;Emotional;Equipment;experimental study;Face;Facial Muscles;Facial nerve structure;FDA approved;feasibility testing;Functional disorder;functional improvement;Functional Magnetic Resonance Imaging;functional outcomes;Head;Health Surveys;Histology;image guided;improved;Individual;innovation;Left;Location;Magnetic Resonance Imaging;Major Depressive Disorder;Measures;Mental Depression;Methods;model development;Outcome;Outcome Measure;Outcome Study;Pain;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Physiologic pulse;Prefrontal Cortex;Process;psychosocial;Psychotherapy;Publishing;Quality of life;Recovery;repetitive transcranial magnetic stimulation;Reporting;Research Personnel;Resistance;Resolution;response;Rest;Sampling;Scalp structure;Severities;standard of care;System;Testing;Therapeutic;tool;Training;Training Programs;Transcranial magnetic stimulation;Treatment Failure;Validation;Veterans;virtual;Vision;World Health Organization Disability Assessment Schedule

PROJECT_TITLE: Targeting Functional Improvement in rTMS Therapy

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: RICHMOND

ORG_NAME: INTERSTATE SHELLFISH SANITATION CONF

ORG_STATE: VA

PHR: Project Narrative This project will enhance both the effectiveness and uniformity of the National Molluscan Shellfish Safety Program by improving the flow of information between federal and state regulatory agencies, industry, and consumers. The project will strengthen state activities by providing assistance in such areas as procedural and policy guidance, technical training, research, consumer education, and conformity with requirements of the National Shellfish Sanitation Program (NSSP) Model Ordinance. The project provides for research opportunities related to shellfish safety which is used by state authorities to assist in the development and implementation of effective biotoxin management and Vibrio risk control plans for implementation by states and industry that area consistent with current science, epidemiology, and HACCP based food safety measures. _____________________________________________________________________________________________ Appendix A Grant Application RFA-FD-11-023 Page 1 of 1

PI_NAMEs: SKILES, BRIAN KEITH (contact)

PROGRAM_OFFICER_NAME: ABBOTT, MELISSA

PROJECT_TITLE: Shellfish Safety Assistance Project


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Immunotherapy;Infectious Diseases;Nanotechnology;Neurosciences;Substance Misuse

ORG_NAME: WISTAR INSTITUTE

PHR: Narrative The inability of antiretroviral therapy (ART) to clear HIV infection and the observation that a sterilizing cure and/or stable remission can be achieved by a subset of ART-treated persons has galvanized interest to advance clinical strategies towards a cure and/or stable remission. Including scientists from 12 institutions and 9 industry partners, the BEAT-HIV Delaney Collaboratory will seek to develop and test innovative combined immunotherapy strategies to permanently suppress and/or eradicate HIV in the absence of ART.

PI_NAMEs: MONTANER, LUIS J (contact);RILEY, JAMES L.;SILICIANO, ROBERT F

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Achievement;Address;Adoptive Transfer;Affect;Aftercare;AIDS clinical trial group;antiretroviral therapy;Area;Basic Science;Behavioral Sciences;Binding;biobank;Blood;cancer therapy;CCR5 gene;CD34 gene;CD8-Positive T-Lymphocytes;Cells;chimeric antigen receptor;Clinical;Clinical Data;Clinical Trials;Collaborations;collaboratory;Combination immunotherapy;Communication;Communities;community engagement;COVID-19;delivery vehicle;design;Development;Disease remission;DNA;Education;Ensure;Epigenetic Process;Ethics;Foundations;Future;Goals;HIV;HIV Infections;HIV-1;humanized mouse;Immune;Immunotherapeutic agent;Immunotherapy;in vivo;Industry;industry partner;Infection;innovation;insight;Institution;Integration Host Factors;interest;Interruption;Intervention;Intrinsic factor;Knowledge;knowledge base;latent HIV reservoir;Lead;Link;Maintenance;Mediating;Mission;Modeling;nanotherapy;Natural Killer Cells;nonhuman primate;novel;novel strategies;patient derived xenograft model;Persons;pressure;prevent;Proviruses;reactivation from latency;Reproducibility;Research;Research Personnel;Resource Allocation;Resources;response;Scientist;Series;simian human immunodeficiency virus;Social Behavior;Testing;Therapeutic;therapeutic nanoparticles;therapy development;Tissues;Viral;viral rebound;Viral reservoir;Viremia;Virus Integration

PROJECT_TITLE: BEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination Immunotherapy


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: DAVIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Musculoskeletal disease affects more than half of people aged 18 and over, and nearly three out of four aged 65 and over. There remains a disconnect between the needs of mechanistic researchers and clinicians who treat musculoskeletal trauma, disease and associated sequelae in the patients of today. We propose that a training program designed for co-mentoring of predoctoral students in an environment and culture providing strong transdisciplinary support for clinical and mechanistic research in musculoskeletal health will result in a new generation of researchers who can develop and implement novel strategies to describe and combat diseases of the musculoskeletal system in the near and far term.

PI_NAMEs: LEACH, J. KENT (contact);RANDALL, ROBERT L.

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TITLE: MUSCLE: MUsculoSkeletal Clinical Learning Experience Transdisciplinary Musculoskeletal Research Training Program


NIH_SPENDING_CATS: Infectious Diseases;Lyme Disease;Prevention;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: This proposal address one of the specific Focus Areas listed in the RFA “Targeted Prevention for Tickborne Diseases”: reservoir-targeted approaches to interrupt the natural history of infection. The proposed research is relevant to public health because it develops a strategy to eliminate the Lyme disease pathogen in its enzootic cycle. Outcome of the study will have significant impact on combating Lyme disease.

PI_NAMEs: SINTIM, HERMAN O;YANG, X. FRANK  (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: acaricide;Address;Animal Experimentation;Animals;Antibiotics;Area;Bacteria;Bacterial Physiology;Black-legged Tick;Borrelia burgdorferi;Chemicals;Chemistry;Data;diguanylate cyclase;Dinucleoside Phosphates;Doxycycline;drug discovery;Drug Targeting;enzootic;experimental study;Foundations;Health;Human;Incidence;Infection;infection rate;infection risk;inhibitor;Interruption;Lyme Disease;Mammals;Mus;Natural History;Nature;Order Spirochaetales;Outcome;Outcome Study;pathogen;Pathway interactions;Patients;Periodicity;Prevention;professor;Public Health;Radioactivity;Reactive Oxygen Species;Reporting;Research;Risk Reduction;Rodent;screening;Second Messenger Systems;Signal Pathway;Signal Transduction;small molecule inhibitor;System;Testing;tick population;Tick-Borne Diseases;Ticks;Vaccines;vector tick;Work

PROJECT_TITLE: Targeting Cyclic Dinucleotide Signaling Pathways to Interrupt the Nature Cycle of Borrelia burgdorferi


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: WASHINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Blood flow is critical to the function of every organ yet the fundamental mechanisms regulating blood flow remain unclear. We have mapped the arterial system of the mouse and identified specific expression of the ion channel TRPV1 in the vascular smooth muscle that encircles the small arterioles of the heart, skeletal muscle, and adipose tissue. We will test the hypotheses that TRPV1 regulates rapid changes in arterial caliber, that the underlying mechanism involves a temperature and phospholipase C dependent pathway, and that adaptations to TRPV1 in arteries enable the persistent activation required for tone.

PI_NAMEs: AHERN, GERARD P (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Adipose tissue;Affect;Afferent Neurons;Aging;Agonist;Arteries;arteriole;Binding;Binding Sites;Blood;Blood flow;Blood Pressure;Caliber;Cardiac Output;Cells;Data;density;desensitization;Diabetes Mellitus;Exercise;Feedback;G-Protein-Coupled Receptors;Genetic;Heart;Heart Diseases;hemodynamics;Hindlimb;Homeostasis;Hyperemia;Impairment;in vivo;innovation;intravital imaging;Ion Channel;Ion Channel Gating;Ischemia;Knock-in;Knockout Mice;Limb structure;Maps;mechanical stimulus;mechanotransduction;Mediating;Mus;Muscle;Muscle Cells;Muscle Contraction;mutant;Myocardium;optogenetics;Organ;Pathology;Pathway interactions;Performance;Perfusion;Peripheral;pharmacologic;Phosphatidylinositols;Phospholipase C;Phosphorylation;Physiological;pressure;prevent;Process;Property;Protons;reactive hyperemia;Regulation;Reporter;Resistance;response;Rest;Role;Sepsis;Signal Transduction;Site;Skeletal Muscle;skeletal tissue;Smooth Muscle;Smooth Muscle Myocytes;spatiotemporal;Speed;stoichiometry;Stretching;System;Temperature;Testing;Tissues;TRPV1 gene;Vascular Smooth Muscle;vasoconstriction;Vasodilation;voltage clamp

PROJECT_TITLE: TRPV1 and the regulation of arterial tone

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: RALEIGH

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: PROJECT NARRATIVE Pulmonary fibrosis is characterized by formation of fibrotic lesions in the lung, eventually resulting in scarring and progressive loss of lung function, and despite some newer treatments patients still have a median survival rate of only 3-5 years once diagnosed. Inhalation of exosomes derived from stem cells offers a promising therapeutic strategy by promoting endogenous repair and mitigating pulmonary fibrosis. Here in this proposed study, we plan to establish the therapeutic role of lung stem cell-derived exosomes in treating pulmonary fibrosis and determine the active principal microRNA contents in the exosomes that responsible for the regenerative activities.

PI_NAMEs: DINH, PHUONG-UYEN C (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: adult stem cell;Allogenic;antifibrotic treatment;Apoptosis;Autologous;Bleomycin;Cell Communication;Cell secretion;Cell Therapy;Cell Transplantation;cell type;Cells;cellular targeting;Cicatrix;Clinical;clinical translation;Clinical Trials;Connective Tissue;Coupled;COVID-19/ARDS;curative treatments;Data;Development;Diagnosis;differential expression;Disease;disease model;Disease Progression;Dose;Down-Regulation;Electroporation;engineered exosomes;exosome;extracellular vesicles;Face;Fibroblasts;Fibrosis;fibrotic lung;first-in-human;Future;Gene Expression;Gene Expression Profiling;Genes;Genomic approach;idiopathic pulmonary fibrosis;immunogenicity;in vivo;Infiltration;Infusion procedures;Inhalation;inhibitor;knock-down;Label;loss of function;Lung;lung injury;lung repair;Lung Transplantation;Macrophage;Maps;Mediating;Mediator;MicroRNAs;Modeling;Molecular;Molecular Target;Nanostructures;non-genetic;novel;novel therapeutic intervention;Ontology;Pathway Analysis;Pathway interactions;Patients;Play;Population;preclinical efficacy;preclinical safety;preservation;Process;Pulmonary Fibrosis;pulmonary function;Rattus;Recombinant Proteins;Recovery;regenerative;Regenerative Medicine;repaired;Resolution;response;Risk;Rodent Model;Role;Route;Safety;Severities;Severity of illness;single cell sequencing;single-cell RNA sequencing;Small Interfering RNA;Source;spheroids;stem cell exosomes;stem cell therapy;stem cells;Survival Rate;Testing;TGF Beta Signaling Pathway;Therapeutic;Therapeutic Effect;therapeutic miRNA;tissue repair;Transforming Growth Factor beta;Tumorigenicity;uptake;Vesicle;Visualization;Work

PROJECT_TITLE: Inhalation Delivery of Exosome and microRNA Therapy for Lung Fibrosis

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Radiation Oncology;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative: The proposed research is relevant to public health because automating high quality brachytherapy treatment planning for cervical cancer will improve the efficiency and reduce the complexity of brachytherapy. These tools could lead to improved patient outcomes by enabling more centers to offer the standard of care, decreasing sedation time, and reducing plan quality variations. This approach has the potential to automate brachytherapy planning for all types of cancer, beyond cervical cancer.

PI_NAMEs: MEYERS, SANDRA MICHELLE (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: 3-Dimensional;Affect;Algorithms;Anatomy;automated treatment planning;Automation;Blinded;Brachytherapy;cancer therapy;cancer type;career development;Cervical;Cessation of life;Clinical;clinical efficacy;clinical implementation;Clinical Treatment;Clinical Trials;Clinical Trials Design;combat;Complex;computer program;computerized tools;Consumption;convolutional neural network;Country;Data;Decision Making;deep learning;Dose;efficacy evaluation;Ethics;Evaluation;experience;Foundations;Future;Goals;Grant;Human;Image;image processing;implementation barriers;implementation science;improved;Inferior;innovation;Institution;Knowledge;Label;Link;Machine Learning;machine learning model;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of prostate;Malignant Neoplasms;Manuals;Measures;Medical;Mentors;Mentorship;Methods;Modeling;Modernization;optimal treatments;Organ;Output;Patient imaging;Patient-Focused Outcomes;Patients;Physicians;Positioning Attribute;predictive modeling;pressure;Process;prospective;Public Health;Radiation;Radiation Dose Unit;Radiation therapy;Radioactive;Radiotherapy Research;Research;Research Personnel;Resources;Sedation procedure;skills;Source;standard of care;Standardization;Statistical Data Interpretation;Statistical Models;statistics;System;Techniques;Technology;technology validation;Testing;three-dimensional modeling;Time;tool;Toxic effect;Training;Training Programs;treatment planning;tumor;Validation;Variant;Woman;Work

PROJECT_TITLE: Optimizing Efficiency and Quality of Brachytherapy for Cervical Cancer using Machine Learning Based Automation

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Digestive Diseases - (Gallbladder);Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: Typhoid fever is an infectious disease caused by Salmonella Typhi (S. Typhi), a bacterium that causes as many as 20 million new infections and 600,000 deaths annually. Asymptomatic chronic carriers of S. Typhi play a major role in the transmission of typhoid fever, as they intermittently shed the bacteria and can unknowingly infect surrounding individuals. This study aims to characterize novel compounds that target biofilm formation, a process utilized by S. Typhi to establish and maintain chronic carriage in the gallbladder, so that they may be eventually used to prevent and/or cure chronic infections more efficiently than ineffective single antibiotics.

PI_NAMEs: GUNN, JOHN S (contact);MELANDER, CHRISTIAN COREY

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: acute infection;Affinity;alternative treatment;analog;Animals;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antibodies;Bacteria;bacterial lysate;Biological;Biological Assay;Cessation of life;Cholelithiasis;Chronic;chronic infection;Ciprofloxacin;Clinical Trials;Communicable Diseases;Data;detection limit;Development;Disease;Dose;drug discovery;Drug Kinetics;effective therapy;efficacy evaluation;Enteral;Enterobacteriaceae;Exhibits;Fever;Future;Gallbladder;Gastroenteritis;Goals;Human;immune clearance;Immune response;In Vitro;in vivo;Individual;Infection;innovation;interest;Intervention;Investigation;Life;Location;Maintenance;Measures;Medical;Methods;Microbial Biofilms;Modeling;Molecular Target;Monitor;Morbidity - disease rate;mortality;mouse model;Mus;mutant;next generation;novel;novel therapeutics;Operative Surgical Procedures;Outcome Study;pathogen;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;prevent;Process;Property;Research;Resistance;Role;Safety;Salmonella;Salmonella typhi;Salmonella typhimurium;Site;small molecule;small molecule inhibitor;Solubility;Structure-Activity Relationship;Systemic disease;Therapeutic Intervention;Time;transmission process;Treatment Efficacy;Typhoid Fever;Work

PROJECT_TITLE: Mechanisms of the Development and Maintenance of Salmonella Gallbladder Carriage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-U(02)M]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative The proposed research is relevant to public health because it will equip me with the necessary skills to examine the underuse of genetic services among African American women at high risk for breast cancer and to identify tools that may increase diffusion of knowledge of genetic counseling among high-risk populations. This project is relevant to NCI's goal of ensuring that a diverse pool of highly trained scientists is available in appropriate scientific disciplines to address biomedical, behavioral, social and clinical research needs in the United States. Moreover, this project is relevant to NCI's mission of launching independent research careers and preparing early investigators to compete for federal grant funding through career development and training.

PI_NAMEs: HENDERSON, VIDA ANN (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Address;Advisory Committees;Affect;African American Women;Applications Grants;Award;Awareness;Behavioral;Behavioral Model;BRCA1 gene;Breast Cancer Risk Factor;Cancer Center;cancer genetics;cancer health disparity;cancer prevention;career;career development;cascade genetic testing;Chicago;Clinical Research;cost;Counseling;Coupled;Data;Decision Aid;Decision Making;design;Development;Development Plans;Diffusion;Discipline;disease-causing mutation;Disparity;Distress;DNA Sequence Alteration;Early Diagnosis;Educational workshop;effectiveness testing;emotional distress;Ensure;Epigenetic Process;ethnic minority;Family member;Federally Qualified Health Center;Funding;General Population;Genes;Genetic;Genetic Counseling;genetic risk assessment;Genetic Services;genetic testing;Goals;Grant;Guidelines;health service use;hereditary risk;high risk;high risk population;High Risk Woman;hormone receptor-negative;Illinois;improved;Individual;Inequity;Inherited;Intervention;intrinsic motivation;Knowledge;Lead;Malignant Breast Neoplasm;Malignant Neoplasms;meetings;Mentors;Mentorship;Methods;minority communities;Minority Women;Mission;mortality;multidisciplinary;Multimedia;Neighborhood Health Center;Not Hispanic or Latino;Pamphlets;Participant;Pathway Analysis;Physicians;Population Heterogeneity;Positioning Attribute;precision medicine;Preventive service;Primary Health Care;Productivity;Provider;Psychosocial Factor;Public Health;Public Health Schools;Race;racial minority;Randomized, Controlled Trials;Recommendation;Research;Research Activity;Research Personnel;Risk;risk perception;Scientist;Self Determination;Services;skill acquisition;skills;social;Social Network;social relationships;socioeconomics;Structure;systemic barrier;Testing;theories;Time;tool;Training;Training Activity;Translational Research;tumor;underserved minority;United States;Universities;uptake;video coaching;White Women;Woman;Work;Writing

PROJECT_TITLE: Promoting Genetic Counseling among African American Women with Hereditary Risk for Breast Cancer


NIH_SPENDING_CATS: Clinical Research;Diabetes

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: The fact that therapies based on the Glucagon-Like Peptide-1 (GLP-1) pathway and that genetic variation in the GLP-1 receptor lower both fasting and postprandial glucose concentrations has been relatively overlooked. In addition, there is increasing evidence that GLP-1 is synthesized in the endocrine pancreas and supports islet function. We propose a novel series of experiments to understand how endogenous fasting GLP-1 secretion could influence subsequent responses to hyperglycemia in the presence and absence of diabetes.

PI_NAMEs: VELLA, ADRIAN  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Alpha Cell;antagonist;Arginine;Beta Cell;Bolus Infusion;Cell Communication;Cell Physiology;Cellular Stress;Circulation;Data;Diabetes Mellitus;Dipeptidyl Peptidases;Dose;Enteroendocrine Cell;Enzymes;Exhibits;experimental study;exposed human population;Exposure to;Fasting;fasting glucose;Functional disorder;Gastrectomy;Gastric Bypass;Genetic;Genetic Variation;Genotype;GLP-I receptor;Glucagon;glucagon-like peptide 1;Glucose;Glutamine;Human;Hyperglycemia;Impairment;in vivo;Ingestion;inhibitor;Insulin;insulin secretagogues;insulin secretion;Intravenous;islet;Islet Cell;Islets of Langerhans;Mediating;Metabolic;Metabolic stress;Mus;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;Obesity;Pancreas;paracrine;Pathway interactions;peptide hormone;Peptide Hydrolases;Persons;Physiological;Physiology;Production;proglucagon;Prohormone Convertase;Receptor Signaling;response;Rodent;Role;Series;Signal Transduction;Single Nucleotide Polymorphism;Site;Stimulus;stressor;Therapeutic Agents;Variant

PROJECT_TITLE: The effect of endogenous GLP-1 secretion on islet function in vivo


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: College Station

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

PHR: The National Institutes of Health and National Research Council recognize that veterinarians are broadly trained health professionals who are uniquely qualified to lead biomedical research, having an understanding of disease in the context of the whole organism. Veterinary scientists play critical roles in combating disease and safeguarding public health. With this competitive training grant renewal proposal, we hope to help address the national shortage of these highly trained and valuable individuals.

PI_NAMEs: MULENGA, ALBERT  (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TITLE: Comparative Biomedical Research Training for Veterinarians


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative ADPKD, caused primarily due to PKD1 mutations, is a common genetic disorder. We will test if improving the translation of mRNAs produced by the non-mutated PKD1 copy is a new therapeutic opportunity for ADPKD. Our studies will also provide a scientific roadmap to develop PKD1-boosting drugs for ADPKD treatment.

PI_NAMEs: PATEL, VISHAL  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Ablation;Address;Adult;Affect;Alleles;Attenuated;Autosomal Dominant Polycystic Kidney;Base Sequence;Binding;c-myc Genes;Cells;Chemicals;Chronic;clinical investigation;Clinical Research;Cyclic AMP;Cyst;derepression;design;Disease;disease model;dosage;Drug Targeting;early onset;End stage renal failure;Epigenetic Process;Epithelial cyst;Evolution;Exhibits;feasibility testing;FRAP1 gene;Gene Dosage;Genetic;Genetic Diseases;Germ-Line Mutation;Goals;Growth;Human;human disease;human model;improved;In Vitro;Individual;Inflammation;Inherited;Mediating;Messenger RNA;Metabolism;MicroRNAs;Modeling;Modification;mouse model;mRNA Translation;Mus;Mutate;Mutation;Names;novel;novel therapeutics;Oligonucleotides;Pathogenicity;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phase Ib Trial;PKD1 gene;Polycystic Kidney Diseases;pre-clinical;Prevalence;prevent;programs;Proprotein Convertase 1;Publishing;Repression;Safety;Testing;Therapeutic;tolvaptan;transcriptomics;Treatment Efficacy;Tubular formation;Untranslated Regions;urinary;Variant;Work

PROJECT_TITLE: PKD1 derepression as a potential therapy for Polycystic Kidney Disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Levothyroxine is widely prescribed to treat hypothyroidism, though no clinical trials have been performed to assess treatment goals in older people. The proposed clinical trial will examine the clinical consequences of allowing greater flexibility in levothyroxine dosing in older people.

PI_NAMEs: CAPPOLA, ANNE R (contact)

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: Adult;Age;Atrial Fibrillation;blood pressure control;bone turnover;C-telopeptide;Cardiovascular system;Clinical;clinical practice;Clinical Treatment;Clinical Trials;clinically relevant;Cognitive;cognitive function;cognitive testing;Confidence Intervals;cost;Data;Diabetes Mellitus;Disease;Dose;Double-Blind Method;Drug Prescriptions;evidence base;executive function;flexibility;Frequencies;Functional disorder;glycemic control;Goals;Guidelines;Health;Health Expenditures;Health Status;Hip Fractures;human old age (65+);Hypertension;Hypoglycemia;Hypotension;Hypothyroidism;Individual;Laboratories;LDL Cholesterol Lipoproteins;Left;Lipids;Measures;Medicare;Memory;Monitor;Moods;Musculoskeletal;Observational Study;older adult;Older Population;Outcome;overtreatment;Patient Outcomes Assessments;Patients;peer;Persons;pharmacologic;Physiological;Population;Population Distributions;primary outcome;Quality of life;Questionnaires;Randomized;randomized placebo-controlled clinical trial;Reference Values;Risk;Risk Reduction;Risk-Benefit Assessment;secondary outcome;Sleep;Symptoms;Testing;Therapeutic Index;Thyroid Diseases;Thyroid Function Tests;Thyroid Gland;Thyroid Hormones;Thyrotropin;Thyroxine;Titrations;Weight

PROJECT_TITLE: Levothyroxine Dosing in Older Individuals

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative The visual system has a remarkable ability to adapt to altered environments, not only sudden changes in light intensity but also the long-term changes in seasonal light periods. Such adaption is supported by structural plasticity of photoreceptors that involves two important cellular stress pathways, the Unfolded Protein Response and autophagy, with both of them linked to numerous diseases ranging from neurodegeneration to cancer. This proposal combines biochemical and genetic approaches to define the role of a candidate regulatory kinase that potentially reveals a novel layer of regulation in the maintenance of visual processing in health and disease.

PI_NAMEs: KRAMER, HELMUT J (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Addictive Behavior;Amaze;arm;Automobile Driving;Autophagocytosis;Biochemical;biological adaptation to stress;Biological Models;Blindness;Cell membrane;cell type;Cells;cellular microvillus;Cellular Stress;circadian;Darkness;Data;Deterioration;Disease;Down-Regulation;Drosophila genus;Elements;Environment;Exhibits;Experimental Genetics;experimental study;fly;Genes;Genetic;genetic approach;Goals;Health;Light;light intensity;Link;Maintenance;Malignant Neoplasms;Measures;Membrane Proteins;Molecular;Morphology;mutant;Nerve Degeneration;Nervous System Disorder;Neurons;neurotransmission;novel;Organelles;Pathology;Pathway interactions;Personal Satisfaction;Phenocopy;Phenotype;Phosphotransferases;Photoreceptors;Phototransduction;Physiological;Play;Process;Proteins;Regulation;response;Role;screening;Seasons;sleep regulation;Stress;Synapses;System;Testing;Time;tool;Traumatic Brain Injury;Vertebrates;Visual;Visual Acuity;visual processing;Visual System

PROJECT_TITLE: Role of stress responses in regulating photoreceptor structural plasticity

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Cancer;Radiation Oncology

ORG_CITY: RESTON

ORG_NAME: AMERICAN COLLEGE OF RADIOLOGY

PHR: Today’s cancer trials frequently require the use of imaging and/or radiation therapy to achieve the most effective treatment. Rigorous QA of these methodologies secures consistency across participating sites by managing potential variability which would otherwise obscure true therapeutic outcomes.

PI_NAMEs: KNOPP, MICHAEL V;KRY, STEPHEN F (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Aftercare;American College of Radiology;cancer clinical trial;clinical imaging;Clinical Management;clinical trial analysis;Clinical Trials;Clinical Trials Cooperative Group;Clinical Trials Design;Collaborations;Communication;Communication Programs;Consultations;Credentialing;Data;data acquisition;Data Collection;Data Coordinating Center;data management;Data Set;Development;Digital Imaging and Communications in Medicine;Disease;Early Therapeutic-Clinical Trials Network;effective therapy;Ensure;Funding;Grant;Image;imaging facilities;Information Systems;Information Technology;Infrastructure;Leadership;Location;Malignant Neoplasms;member;Methodology;Modality;Modernization;National Cancer Institute;National Clinical Trials Network;Ohio;Oncology Group;oncology service;operation;organizational structure;Outcome;Patient imaging;Patients;Philadelphia;Principal Investigator;Procedures;Process;programs;prospective;protocol development;Qualifying;quality assurance;Radiation Oncology;Radiation therapy;Recommendation;Rhode Island;Secure;Services;Site;Specific qualifier value;Subgroup;synergism;Technical Expertise;Technology;therapy outcome;tool;trial design;Uncertainty;Universities;Vision;Washington;Work

PROJECT_TITLE: Imaging and Radiation Oncology Core (IROC) Group


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pneumonia;Pneumonia and Influenza;Precision Medicine

PHR: PROJECT NARRATIVE Pneumonia remains the leading infectious cause of death. Presently doctors do not know which patients can benefit from steroids, when to give steroids, or how much steroid to give. In this application, we propose an approach to steroid use in pneumonia that considers an individual’s unique features, seeking to give the right dose of steroid to the right patient and at the right time.

PI_NAMEs: ODEYEMI, YEWANDE  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: acute COVID-19;acute hypoxemic respiratory failure;Acute Respiratory Distress Syndrome;Adoption;Adrenal Cortex Hormones;Adult;Anti-Inflammatory Agents;Biological Markers;Biometry;C-reactive protein;Cause of Death;Characteristics;Clinic;Clinical;clinical practice;clinical predictors;Clinical Trials;Clinical Trials Design;community acquired pneumonia;Complication;Coupled;COVID-19 pandemic;COVID-19 patient;COVID-19 pneumonia;Critical Care;Critical Illness;Data;Data Science;Demographic Analyses;demographics;Deterioration;Disease Progression;Dose;effectiveness testing;electronic health data;Electronic Health Record;evidence base;experience;Future;Goals;Grant;Guidelines;Hospitalization;Hospitals;Hypoxemia;implementation science;improved;Individual;individualized medicine;Inflammation;Inflammatory Response;Investigation;K-Series Research Career Programs;Knowledge;Laboratories;machine learning method;machine learning prediction;Methodology;multidisciplinary;Outcome;Outcomes Research;Oxygen;Pathologic;patient response;Patient Selection;Patient-Focused Outcomes;Patients;personalized approach;Physiological;Pneumonia;Population;Population Heterogeneity;Pragmatic clinical trial;predictive tools;primary outcome;prognostic;prognostic tool;Recovery;Research;Research Personnel;Resolution;Retrospective cohort;Risk;risk prediction;Sample Size;skills;statistical and machine learning;Steroids;success;Testing;Time;Training;treatment as usual;trial comparing

PROJECT_TITLE: Individualizing Steroid Use in Pneumonia


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE Mycobacterium tuberculosis (Mtb) is the number one infectious disease killer in the world. Altering mitochondrial homeostasis has been repeatedly associated with susceptibility to Mtb and exacerbation of Mtb pathogenesis. By understanding how crosstalk between Mtb virulence factors and mitochondria influences immune outcomes, we might one day be able to therapeutically target mitochondria as part of tuberculosis patient treatment plans.

PI_NAMEs: PATRICK, KRISTIN LEIGH;WATSON, ROBERT OWEN (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Aerosols;Automobile Driving;Bacteria;Bacterial Infections;Biology;Cell Death;Chronic;Chronic Disease;Communicable Diseases;Crohn's disease;Curiosities;Cytosol;Data;Defect;design;Disease;Disease Outcome;Dose;ds-DNA;Ectopic Expression;ELF3 gene;Environment;Equilibrium;experimental study;Genes;Genetic Predisposition to Disease;genome wide association study;Guanosine Triphosphate Phosphohydrolases;Health;Homeostasis;Human;human disease;human model;Immune;Immune response;improved;in vivo;Infection;Inflammasome;Inflammation;Inflammatory;innate immune pathways;Innate Immune Response;innovation;insight;interest;Interferon Type I;IRF3 gene;Knock-in Mouse;Knowledge;leucine-rich repeat protein;Ligands;Link;LRRK2 gene;Macrophage;Mediating;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial therapeutics;Modeling;Molecular;mouse model;Mus;mutant;Mutation;mycobacterial;Mycobacterium Infections;Mycobacterium tuberculosis;Natural Immunity;Nature;novel;Outcome;Outer Mitochondrial Membrane;PARK2 gene;Parkinson Disease;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Permeability;permissiveness;Phagosomes;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;PINK1 gene;Play;Population;Predisposition;Production;Proteins;Research;Role;sensor;Severities;Severity of illness;Side;Stimulator of Interferon Genes;synergism;System;Technology;Therapeutic;Therapeutic Intervention;treatment planning;Tuberculosis;Virulence Factors

PROJECT_TITLE: Mitochondria as crucial regulators of innate immune outcomes during Mycobacterium tuberculosis infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Dysfunctions of decision making are core characteristics of various mental illnesses such as addiction, major depression and eating disorder. Here, we seek to develop and apply novel technologies in spatial single-cell omics and in vivo tracing and imaging to determine the neural basis of decision making. These studies will uncover fundamental insights into the brain mechanisms underlying the debilitating cognitive impairments associated with mental disorders and provide translational inroad for the intervention and treatment of these disorders.

PI_NAMEs: WU, ZHENG HERBERT (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: addiction;Address;Amygdaloid structure;Anterolateral;Architecture;Area;Atlases;Behavior;Behavioral;Behavioral Paradigm;Biological;Brain;brain pathway;Calcium;cell cortex;cell type;Cells;Censuses;Characteristics;Cognition;Cognitive;Cognitive deficits;cognitive function;Complex;Coupling;Data;data to knowledge;Decision Making;Disease;Dissection;Eating Disorders;endophenotype;excitatory neuron;Exhibits;expectation;experimental study;Functional disorder;Genes;Genome;Goals;hippocampal pyramidal neuron;Human;Image;Impaired cognition;in vivo;in vivo imaging;individual response;inhibitory neuron;innovation;insight;Interneurons;Interoception;Intervention;Knowledge;Link;Location;Major Depressive Disorder;Maps;Mediating;Mental disorders;Methods;Molecular;Molecular Profiling;Motor;motor control;Motor Cortex;Movement;Mus;neural;neural circuit;neuromechanism;Neurons;new technology;nonhuman primate;novel;Odors;optogenetics;Parietal Lobe;Parvalbumins;Pathology;Pathway interactions;Pattern;Population Dynamics;Post-Traumatic Stress Disorders;Prefrontal Cortex;Preparation;Primates;Process;Research;response;Rewards;Role;Sampling;sensory stimulus;Short-Term Memory;single-cell RNA sequencing;Somatostatin;Source;Stimulus;Structure;System;Taxonomy;Testing;tool;Tracer;transcriptomics;Translating;Transplantation;Vasoactive Intestinal Peptide;Work

PROJECT_TITLE: Molecular and functional architecture of a premotor circuit for decision making


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE My career goal is to become a cancer researcher leading a program focused on the translation of evidence- based genetics applications such as family cancer history (FCH) collection to improve risk-stratified cancer prevention and early-detection in low-resource settings. In the F99 phase, I will complete my dissertation research focused on identifying factors influencing collection of FCH, while gaining skills in social network data analysis. During the K00 phase, I will extend this research and training by: 1) building knowledge of human centered design to incorporate F99 findings about determinants of FCH collection into an updated FCH tool, 2) becoming an expert in implementation science through the deployment and evaluation of a FCH intervention in community health settings, and 3) enhancing skills to prepare for an academic research position.

PI_NAMEs: ALLEN, CAITLIN GLOECKNER (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: academic preparation;Adult;African American;African American population;Award;Belief;Cancer Burden;cancer care;cancer genetics;cancer prevention;cancer risk;career;career development;Clinic;Clinical;clinical decision-making;Collection;Color;Communication;Communities;Community Clinical Oncology Program;Community Health;Complex;Continuity of Patient Care;Data Analyses;Death Rate;design;Development;Disparity;Early Diagnosis;Effectiveness of Interventions;effectiveness outcome;Environment;Ethnic Population;Evaluation;evidence base;Family;Family Cancer History;Family dynamics;Family health status;family influence;Family member;Fellowship;follow-up;Genetic;genetic information;Genetic Research;Genetic Risk;Goals;Health;Health Technology;human centered design;implementation outcomes;implementation research;implementation science;improved;Individual;innovation;Intervention;Interview;Knowledge;Learning;Link;Literature;Malignant Neoplasms;Maps;marginalized population;Medical;member;Mentors;Mentorship;Methodology;Methods;Minority Groups;NCI-Designated Cancer Center;Network-based;novel;Outcome;Participant;Pathway Analysis;Patients;Personal Behavior;Phase;population health;Positioning Attribute;Postdoctoral Fellow;pragmatic trial;Prevention strategy;primary care setting;programs;Provider;Public Health Schools;racial population;Recording of previous events;Reporting;Research;research and development;research data dissemination;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Project Summaries;Resource-limited setting;Resources;Risk;Risk Reduction;risk stratification;screening;Site;skills;Social Network;systematic review;Techniques;Technology Assessment;tool;Training;training opportunity;Translating;Translational Research;Translations;Underrepresented Populations;underserved minority;Universities;Update;uptake;Work;Writing

PROJECT_TITLE: Improving Family Cancer History Collection using Social Network, Human Centered Design, and Implementation Science Approaches


NIH_SPENDING_CATS: Cancer;Hematology;Immunotherapy;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Narrative This project is highly relevant to public health as its main objective is to lead to better treatments for cancer. As the current cancer therapeutics have low efficacy particularly for relapsed, refractory disease, there is a significant need for new strategies such as improved NK cell therapies.

PI_NAMEs: WALD, DAVID  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Activated Natural Killer Cell;Acute Myelocytic Leukemia;Address;Adverse event;Antigens;Biological;Biological Assay;cancer cell;Cancer cell line;Cancer Etiology;Cancer Patient;cancer therapy;cell killing;Cell Surface Receptors;Cellular immunotherapy;Cessation of life;Chemicals;circulating leukemia cell;Clinical;clinical efficacy;Clinical Trials;Collection;Cytolysis;cytotoxic;cytotoxicity;Development;Dose;Enhancers;Epithelial ovarian cancer;Future;Hematologic Neoplasms;human cancer mouse model;human model;Immunodeficient Mouse;Immunotherapy;improved;In Vitro;in vivo;insight;Lead;Libraries;Ligands;Lymphocyte;Lymphocyte Subset;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Mediator;metastatic colorectal;Molecular;Natural Killer Cells;neoplastic cell;NK Cell Activation;NK cell therapy;Normal Cell;novel;Patients;Phenotype;Predisposition;Property;Public Health;receptor;Refractory;Refractory Disease;Relapse;safety testing;Series;small molecule;Solid Neoplasm;success;System;Testing;Therapeutic;Woman;Work

PROJECT_TITLE: HTS for the discovery of activators of NK cell cytotoxicity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-F(55)R]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Rare Diseases

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative Cyclic nucleotide-gated (CNG) channels are essential for vision and olfaction. Numerous genetic mutations in these channels cause debilitating visual disorders such as retinitis pigmentosa and achromatopsia. Obtaining high-resolution structures of wild-type and mutant CNG channels in different states and carrying out structure- guided functional studies is crucial for understanding how these channels are controlled by cyclic nucleotides and how disease-associated mutations disrupt channel function, and for developing appropriate treatments for patients.

PI_NAMEs: YANG, JIAN  (contact)

PROJECT_TERMS: achromatopsia;Binding;Biophysics;Brain;Caenorhabditis elegans;Cations;Cells;Charge;Chemicals;Complex;Cone;Cryoelectron Microscopy;Cyclic AMP;Cyclic GMP;Cyclic Nucleotides;cyclic-nucleotide gated ion channels;Cytoplasm;dimer;Disease;DNA Sequence Alteration;Floods;gain of function mutation;Genes;Human;Ions;Knowledge;Length;Ligands;Link;loss of function;Missense Mutation;Molecular;Molecular Conformation;mutant;Mutate;Mutation;Neurons;Olfactory Receptor Cells;Patients;Photoreceptors;Physiology;Play;Property;Reporting;Resolution;Retinal Cone;retinal rods;Retinitis Pigmentosa;Role;Sensory;Signal Transduction;Smell Perception;Sodium Chloride;Structure;Testing;therapeutic development;Vestibule;Vision;Vision Disorders

PROJECT_TITLE: Molecular physiology and biophysics of cyclic nucleotide-gated channels

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology;Prevention;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative Crimean-Congo hemorrhagic fever is the most widespread tick-borne viral disease in humans with case- fatality rates of 10–40%. Here we propose to employ structure-based vaccine design principles to engineer immunogens that induce cross-reactive protective antibodies. Our studies will provide insight into the structures and antigenicity of CCHFV glycoproteins and will deliver a bona fide vaccine candidate against a NIAID Category A pathogen.

PI_NAMEs: CHANDRAN, KARTIK ;MCLELLAN, JASON SCOTT (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acute;Africa;Animal Model;Antibodies;Antibody Response;Antibody Therapy;Antigens;Case Fatality Rates;Categories;Category A pathogen;Cells;Central Asia;Chimeric Proteins;Classification;clinical development;Complex;Coronavirus;Crimean Hemorrhagic Fever;Crimean-Congo Hemorrhagic Fever Virus;cross reactivity;Data;Data Protection;design;Disease;Disease Outbreaks;disorder prevention;Dyes;Engineering;Epitope Mapping;Epitopes;Evaluation;experience;Family;Filovirus;Funding;Genome;Geographic Locations;global temperature;Glycoproteins;Goals;Human;IFNAR1 gene;Immune response;Immunocompromised Host;immunogenicity;Immunologics;improved;in vivo;Incidence;insight;interest;International;Laboratories;lead candidate;Licensing;Life;Livestock;medical countermeasure;Membrane Fusion;Middle East;migratory bird;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;Mucins;Mus;Nairovirus;nanoparticle;National Institute of Allergy and Infectious Disease;neutralizing antibody;novel;novel vaccines;Pathogenesis;Patients;prevent;Process;Proteins;Public Health;Reagent;Respiratory syncytial virus;RNA Viruses;Sampling;self assembly;Site;Southern Europe;structural glycoprotein;Structure;Subunit Vaccines;synergism;Technology;Therapeutic antibodies;tick-borne;Tick-Borne Diseases;tick-borne pathogen;Ticks;tool;type I interferon receptor;Vaccine Antigen;vaccine candidate;Vaccine Design;vaccine development;Vaccines;vector;Viral;Viral Envelope Proteins;Viral Genome;Viral Hemorrhagic Fevers;Virus;Virus Diseases;Western Asia;Work

PROJECT_TITLE: Structure-based Vaccine Design for CCHFV


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: NOVOBIOTIC PHARMACEUTICALS, LLC

PHR: NARRATIVE The fungal pathogen Candida auris is a major public health concern, particularly in healthcare facilities and nursing homes. The focus of this project is to screen our unique microbial culture collection for new drugs to combat C. auris.

PI_NAMEs: SPOERING, AMY LYNN (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acute;Address;Amphotericin B;analog;animal efficacy;Anti-Bacterial Agents;anti-fungal agents;Antibiotics;Antitubercular Agents;Bacteria;Bacterial Infections;Biological Assay;Bioreactors;Candida auris;Categories;Cell Line;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chemical Structure;Chemicals;Classification;Clinical;Collection;combat;COVID-19;Crude Extracts;cytotoxicity;cytotoxicity test;Databases;Death Rate;Development;Disseminated candidiasis;Dose;Droughts;drug discovery;Drug Kinetics;Drug resistance;efficacy study;Environment;falls;Fermentation;Fractionation;fungicide;fungus;Goals;Growth;Growth Factor;Health care facility;Hospitalization;Hospitals;Immunocompromised Host;In Vitro;in vivo;in vivo evaluation;Infection;Laboratories;Lead;Liquid substance;Mammalian Cell;Maximum Tolerated Dose;Microbe;microbial;microorganism;milligram;minimal inhibitory concentration;Modeling;mouse model;Multi-Drug Resistance;Mus;mutant;Mycoses;Natural Compound;Natural Resources;novel;novel antibiotic class;novel lead compound;novel therapeutics;Nursing Homes;Nystatin;pathogen;pathogenic fungus;Patients;Phase;Phenotype;pre-clinical research;preclinical development;Production;programs;Public Health;Qualifying;Reporter;Resistance;resistance frequency;resistant strain;Safety;scale up;screening;screening program;secondary metabolite;Skin;Soil;Source;Staphylococcus aureus;Structure;Technology;Testing;Validation;Yeasts

PROJECT_TITLE: Antifungal discovery from previously uncultivated bacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: TEMPE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Large segments of current US middle-aged adults are suffering and doing more poorly than earlier-born cohorts and these trends are distinct to the US, compared to other Asian and European nations. Despite known differences between the US and other nations, little research has examined the mechanisms underlying diversity in midlife development and individual-level characteristics that either magnify or mitigate differences. Our objective is to use the HRS family of studies to identify the intergenerational, financial, and health behavior mechanisms driving diversity in midlife development of health, well-being, and cognition and shed light on individual-level characteristics that can promote resilient outcomes and inform future prevention, policy, and intervention efforts.

PI_NAMEs: GERSTORF, DENIS ;INFURNA, FRANK JOHN (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Address;Adult;Adult Children;Age;aged;Aging;Area;Asia;Asian;Automobile Driving;Behavioral Mechanisms;Belief;caregiving;Caring;Characteristics;Chronic Disease;Cognition;cohort;Comprehensive Health Care;Data;Data Set;Deaths of despair;Dependence;Development;disability;Disparity;Disparity population;driving force;Drug usage;economic value;Education;Empirical Research;Europe;European;Exhibits;Face;Family;Family member;Family Study;Future;Gender;Generations;Germany;Health;Health behavior;health care service utilization;health difference;Healthcare Systems;Hour;human old age (65+);improved;Income;Individual;informal care;insight;intergenerational;Intervention;Life Expectancy;Mediation;Mexico;middle age;Modeling;multilevel analysis;North America;novel;Outcome;Parents;peer;Personal Satisfaction;Physical activity;physical conditioning;Policies;Population;Prevention;Process;Productivity;promote resilience;psychosocial;psychosocial resources;Public Health;Race;Reporting;Research;resilience;resilience factor;Resources;Risk;Risk Factors;Role;safety net;Sampling;Savings;Social Controls;social factors;Social support;Societies;sociodemographics;South Korea;trend;Vertebral column;Work

PROJECT_TITLE: Psychosocial Risk and Resilience Mechanisms Underlying Diversity in Midlife Health, Well-Being, and Cognition

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-J(02)]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: With ~560,000 Alzheimer’s disease (AD) patients and >4 million residents >65 years old, Florida is, and will continue to be, an epicenter of the AD epidemic in the United States. Notably, impressive gains in our understanding of AD pathogenesis have not yet translated into disease-modifying therapies that benefit patients; thus there is huge unmet medical need. The 1Florida ADRC’s global mission is to work with other ADRCs and stakeholders in the AD field to help change the understanding of AD and related dementias (ADRDs) to a new reality in which ADRDs are more facilely and accurately diagnosed, more effectively treated and ultimately preventable or curable.

PI_NAMEs: DUARA, RANJAN ;LOEWENSTEIN, DAVID ;SMITH, GLENN E. (contact)

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: accurate diagnosis;African American population;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid;Autopsy;Biological Markers;Brain;career development;Caring;Caucasians;Classification;Cognitive;cognitive change;cohort;Collaborations;Communities;comorbidity;Cultural Diversity;Data;Data Analyses;data portal;Data Set;data sharing;Databases;Dementia;Diagnosis;Disease;disease heterogeneity;Early Diagnosis;Educational Activities;Enrollment;Environment;Epidemic;ethnic diversity;Ethnic Origin;Etiology;European;Evaluation;Family;Florida;follow-up;Fostering;Funding;Future;Genetic Variation;Goals;Grant;Health Professional;Hispanic;Hispanic Populations;human old age (65+);imaging study;Impaired cognition;improved;Incidence;Individual;innovation;Institution;inter-institutional;International;Intervention;Knowledge;Language;Lewy Body Dementia;Linguistics;Longitudinal cohort;Longitudinal cohort study;Magnetic Resonance Imaging;Medical;Medical center;member;Minority Groups;Mission;Natural History;neuropathology;Neuropsychological Tests;Not Hispanic or Latino;novel;novel marker;Participant;Pathogenesis;Patients;Pilot Projects;Population;Population Heterogeneity;Positron-Emission Tomography;Publications;Race;racial diversity;recruit;Research;Research Personnel;Resources;response;retention rate;Risk Factors;Scanning;Science;Scientist;skills;Spanish;Specialized Center;tool;Training;training opportunity;Translating;Underrepresented Minority;United States;United States National Institutes of Health;Universities;Vascular Diseases;web portal;Work

PROJECT_TITLE: 1Florida Alzheimer's Disease Research Center


ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Narrative The innate immune system restricts the growth of invading bacteria by limiting access to essential nutrient metal ions (nutritional immunity) and by production of antimicrobial peptides and enzymes that attack the cell envelope. Using Bacillus subtilis as a model system, we characterize the bacterial stress responses elicited by metal ion limitation and excess, and by antibiotics that interfere with integrity of the cell envelope. The resulting insights are relevant for understanding the mechanisms that allow bacterial cells (both beneficial and harmful) to adapt to the host environment.

PI_NAMEs: HELMANN, JOHN D (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Address;Affect;Anti-Bacterial Agents;anti-microbial peptide;Antibiotic Resistance;antibiotic tolerance;Antibiotics;Bacillus subtilis;Bacteria;beta-Lactams;biological adaptation to stress;Biological Models;cell envelope;cell killing;Cell Wall;Cells;Clinical;Complex;Environment;Enzymes;Genes;Gram-Positive Bacteria;Growth;Homeostasis;Human;human pathogen;Immune system;Innate Immune System;insight;Intoxication;Invaded;Ions;Iron;Leukocyte L1 Antigen Complex;LytA enzyme;Manganese;Metabolic Pathway;Metals;Modeling;Morbidity - disease rate;mortality;mutant;Nutrient;Nutritional Immunity;Organism;pathogen;pathogenic bacteria;Pathway interactions;Peptides;Phagocytes;Phagocytosis;Physiological;Production;response;Role;Sigma Factor;Stress;synergism;System;Tissues;transcription factor;Virulence;Work;Zinc

PROJECT_TITLE: Bacillus subtilis stress responses

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: SMITH, GLENN E. (contact)

PROJECT_TERMS: African American population;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Appointment;Autopsy;Award;Brain;Budgets;Clinical;clinical research site;Clinical Sciences;cohort;Collaborations;Complex;Consensus;Consent;data management;data sharing;design;Development;diverse data;Doctor of Philosophy;Education;education research;Educational Activities;Ensure;experience;Extramural Activities;Fellowship;Fellowship Program;Florida;Foundations;Funding;Funding Mechanisms;Generations;Goals;Grant;Hispanic Americans;Human Resources;Infrastructure;Institution;interest;Leadership;Letters;Link;Longitudinal Studies;meetings;Pamphlets;Pathologic;Population Heterogeneity;Positioning Attribute;Positron-Emission Tomography;Privatization;Process;programs;Publications;Request for Applications;Research;Research Activity;Research Personnel;Research Support;Resources;Science;Scientist;Site;Source;Spanish/English;Structure;success;symposium;Training;Training and Education;Translational Research;Vision;web site;Work

PROJECT_TITLE: 1Florida Alzheimer's Disease Research Center Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lewy Body Dementia;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: ARMSTRONG, MELISSA JO (contact)

PROJECT_TERMS: Acculturation;Affect;African American;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Amyloid beta-42;Autopsy;bilingualism;Biological Markers;Blood Vessels;blood-based biomarker;Brain;Brain Pathology;Brain region;cerebrovascular;Classification;Clinical;clinical center;clinical research site;Clinical Trials;Cognition;Cognitive;cognitive change;cohort;Collaborations;Communities;comorbidity;Complement;Consent;Data;Dementia;Diagnosis;Diagnostic;Disease;disparity reduction;Early Diagnosis;Education;Elderly;Elements;Enrollment;Ensure;Epidemiology;ethnic diversity;Evaluation;Florida;follow-up;Funding;Genetic;Genotype;Goals;Hispanic;Hispanic Populations;Image;Impaired cognition;improved;Individual;instrument;Investigation;Language;Lewy Body Disease;Longitudinal Studies;Magnetic Resonance Imaging;Medical center;Methodology;Methods;mild cognitive impairment;Minority Groups;Monitor;MRI Scans;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;neuroimaging;neuropathology;Neuropsychological Tests;Neuropsychology;Not Hispanic or Latino;novel;older adult;Parkinson Disease;Parkinsonian Disorders;Participant;Pathology;Performance;Phenotype;Positron-Emission Tomography;preclinical study;Protocols documentation;Qualifying;racial diversity;recruit;Research;Research Activity;Research Personnel;Research Project Grants;research study;retention rate;Site;Spanish/English;Standardization;success;tau Proteins;Training;Underrepresented Minority;Universities;Vascular Dementia;Vascular Diseases

PROJECT_TITLE: 1Florida Alzheimer's Disease Research Center Clinical Core


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because up to sixty percent of arteriovenous fistulas created in hemodialysis patients in the United States fail to mature for successful dialysis use. This project aims to improve the understanding of the mechanisms of arteriovenous fistula maturation failure and develop nanomedicine to treat this important clinical problem. Thus, the proposed research is relevant to the NIH’s mission that pertains to developing fundamental knowledge to help reduce morbidity and mortality for patients on hemodialysis requiring a vascular access.

PI_NAMEs: JAIMES, EDGAR A;SHIU, YAN-TING E. (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Affinity;Animals;Area;Arteriovenous fistula;Binding;Biocompatible Materials;Blood flow;Blood Vessels;Cardiovascular Diseases;Cell Culture System;chemical property;Chronic Kidney Failure;Circulation;Clinical;Data;Development;Dialysis procedure;Disease;Dose Limiting;Drug Delivery Systems;Drug Kinetics;Drug Targeting;effective therapy;Effectiveness;Encapsulated;Endothelial Cells;Engineering;Exhibits;Exposure to;Failure;fucoidan;Gelatinase A;Gelatinase B;Gene set enrichment analysis;Generations;genetic approach;Goals;Half-Life;Hemodialysis;Human;Hyperplasia;improved;In Vitro;inhibitor;injured;innovation;intravenous administration;intravenous injection;Knock-out;Knockout Mice;Knowledge;Ligands;Liposomes;Malignant Neoplasms;Mediator;Mission;Modification;Molecular;Morbidity - disease rate;mortality;Mus;NADPH Oxidase;nanomedicine;nanomolar;nanoparticle;nanoparticle delivery;nanoparticle drug;Nanotechnology;novel;novel therapeutic intervention;Operative Surgical Procedures;P-Selectin;Pathologic;Pathway interactions;patient population;Patients;Peptides;Pharmaceutical Preparations;Phosphorylation;Polysaccharides;posttranscriptional;prevent;Prevention strategy;promoter;Proto-Oncogenes;Public Health;Rattus;Reactive Oxygen Species;Renal function;Research;Rodent;Role;Serum;Site;small molecule inhibitor;targeted delivery;Testing;Therapeutic;Tissues;Toxic effect;transcription factor;transcriptome sequencing;treatment strategy;Ubiquitination;United States;United States National Institutes of Health;Veins;Work

PROJECT_TITLE: Nanotechnology as a therapeutic approach in arteriovenous fistula maturation

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Data Science;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: MARSISKE, MICHAEL  (contact)

PROJECT_TERMS: Algorithms;Alzheimer's Disease;Big Data;Biological Markers;biomedical informatics;Biometry;career;Catalogs;Clinical;Clinical Trials;Code;Collaborations;Communities;Competence;Computer software;Consultations;Data;data acquisition;Data Analyses;Data Collection;data collection site;Data Coordinating Center;data exchange;data handling;data management;Data Management Resources;data repository;Data Security;Data Set;Database Management Systems;Dementia;Development;Diagnosis;distributed data;Documentation;education research;eHealth;Ensure;Equation;Equipment and supply inventories;Fiber;Florida;Geography;Growth;Language;Leadership;Link;Logistic Regressions;longitudinal analysis;machine learning algorithm;Maintenance;Manuscripts;Measures;Methods;Modeling;multilevel analysis;neuroimaging;novel;open data;open source;operation;Participant;Peer Review;phenotypic data;power analysis;Printing;Process;Publications;Pythons;Quality Control;repository;Reproducibility;Research;Research Design;Research Personnel;Research Support;Secure;sound;Source Code;Statistical Data Interpretation;Statistical Methods;statistics;System;tool;Training Activity;Trust;Validation;Work

PROJECT_TITLE: 1Florida Alzheimer's Disease Research Center Data Management and Statistical (DMS) Core


PI_NAMEs: PROKOP, STEFAN  (contact)

PROJECT_TERMS: Agreement;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid;Archives;Autopsy;Biological Markers;Brain;Central Nervous System;Cerebrospinal Fluid;Clinical;clinical diagnosis;Clinical Research;Cognitive;cohort;Consensus;Consent;Consultations;Data;data management;Databases;Diagnosis;Diagnostic;Disease;Disease Progression;DNA;Education;education research;Ensure;Evaluation;Experimental Designs;Freezing;Frontotemporal Lobar Degenerations;Gene Mutation;genetic risk factor;Goals;Guidelines;Human;Individual;Lewy Bodies;mouse model;National Institute on Aging;Needs Assessment;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;Neurofibrillary Tangles;neuropathology;Onset of illness;Pathologic;Pathology;patient subsets;Patients;Plasma;Procedures;protein aggregation;protein TDP-43;Proteins;Qualifying;Research;Research Personnel;Research Support;Resources;response;Sampling;Senile Plaques;Serum;symposium;tau Proteins;Testing;tissue fixing;Tissues;Training Activity

PROJECT_TITLE: 1Florida Alzheimer's Disease Research Center Neuropathology Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Infectious Diseases;Social Determinants of Health;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE In this proposed study, we will use longitudinal data from rural Malawi to examine the effect of marriage on mental and physical health and test whether differences exist by sex and age, i.e., across the life course. We will account for selection into (re)marriage and dissolution by controlling for unobserved characteristics that likely affect both marital status and health and will also consider how marriage patterns, customs, and norms in this context affect this relationship. Ultimately, we will create the first population-based longitudinal dataset on marriage and health in sub-Saharan Africa, which will be the first to include complete marriage histories, detailed measures of health, information for spouses, migration history, HIV/AIDS infection, gender attitudes, and women’s autonomy.

PI_NAMEs: ANGLEWICZ, PHILIP ANTHONY (contact);CHAE, SOPHIA

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Address;Affect;Africa South of the Sahara;African;Age;age difference;aged;Anxiety;Area;Attitude;Behavior;Cessation of life;Characteristics;Communicable Diseases;Couples;Custom;Data;Data Set;Dimensions;Disease;Divorce;divorce/separation;Eastern Africa;Epidemic;Europe;experience;Family;Future;Gender;Health;Health Status;HIV;HIV Infections;HIV Seropositivity;HIV/AIDS;Husband;Individual;Infection;instrument;Left;Life;Life Cycle Stages;Link;longitudinal dataset;Longitudinal Surveys;Malawi;male health;Marital Status;Marriage;Marriage Pattern;Measures;Mediating;Mental Depression;Mental Health;Methodology;Migrant;migration;neglect;North America;Outcome;Perception;physical conditioning;Physical Function;Polygyny;population based;Recording of previous events;Research;Role;Rural;sex;Sex Differences;SF-12;social;social norm;Southern Africa;Spouses;stem;Surveys;Testing;Widow;Wife;Woman

PROJECT_TITLE: Marriage and Health in Malawi