ORG_CITY: TUCSON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE CD4+ T cells survey the body for evidence of microbial infection or altered self and then orchestrate long-lived protective immune responses when a problem is encountered. How they collect the relevant information from an antigen presenting cell (APC) and relay it across their cell membranes to direct their response is a matter of intense interest as this process is fundamental to their role in the immune system. This proposal will shed important new light on how CD4+ T cells relay information across their cell membrane to initiate intracellular signaling events and, in so doing, will serve as a guide for efforts to engineer synthetic receptors that mimic the form and function of their natural counterparts for therapeutic purposes. 1

PI_NAMEs: KUHNS, MICHAEL S (contact);VAN DOORSLAER, KOENRAAD

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: adaptive immune response;Advocate;Antigen Presentation;Antigen-Presenting Cells;Antigens;Architecture;Automobile Driving;base;Basic Science;Biology;Biomimetics;CAR T cell therapy;CD3 Antigens;CD4 Positive T Lymphocytes;CD8B1 gene;Cell membrane;Cellular biology;chimeric antigen receptor;Complex;Computer Analysis;cost;Cytoplasm;Data;design;Disease;Docking;Educational process of instructing;Engineering;Event;Evolution;experimental study;extracellular;fitness;Generations;Goals;Health;Human;Immune response;Immune system;Immunity;improved;in vivo;Infection;interest;ITAM;Knowledge;Light;Maps;Mediating;Membrane;microbial;Modeling;Molecular;mutant;Mutate;Negative Staining;novel;Orthologous Gene;Peptides;Phosphorylation;placental mammal;Process;Productivity;Protein Analysis;receptor;receptor function;Receptor Signaling;recruit;Regulation;Regulatory T-Lymphocyte;response;Role;Signal Transduction;Site;Structure;Surveys;T cell response;T-Cell Activation;T-Cell Development;T-Cell Immunologic Specificity;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Work

PROJECT_TITLE: Evolution-guided analysis of extracellular and intracellular mechanisms driving T cell activation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (02)]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Neurosciences;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SURGERY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project narrative This study is to test small molecule inhibitors of the type I IFN pathway for the treatment of Aicardi- Goutiéres syndrome (AGS), a severe genetic brain disease that often leads to physical and mental disabilities with a high rate of death. Findings from this study will eventually lead to the discovery of an effective drug for AGS treatment and likely also for other type I IFN associated diseases.

PI_NAMEs: WANG, QINGDE  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Animal Model;autoinflammatory;Blood;Brain;brain cell;Brain Diseases;Brain Injuries;Cerebrospinal Fluid;Chronic small plaque psoriasis;Clinical;Clinical Trials;clinically relevant;cognitive disability;comparative efficacy;Controlled Clinical Trials;CRISPR/Cas technology;Data;Death Rate;Development;Disease;Disease Outcome;Double-Blind Method;drug candidate;drug efficacy;effective therapy;efficacy evaluation;efficacy testing;Encephalitis;Encephalopathies;Enrollment;Exhibits;FDA approved;Gene Expression;Genes;Genetic;Immune;immune activation;improved;improved outcome;in vivo;infancy;Inflammatory;Inflammatory Response;inhibitor;insight;Interferon Activation;Interferon Type I;Interferon Type II;Interferons;JAK1 gene;Janus kinase;kinase inhibitor;Medicine;Mental disability;Methods;Modeling;Molecular;Morphology;mouse genome;mouse model;Mus;Mutant Strains Mice;Mutation;neural;neuroinflammation;new therapeutic target;novel therapeutics;Nucleic Acids;open label;Outcome;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;Phenotype;physically handicapped;Placebo Control;Placebos;pre-clinical;preclinical study;prevent;Production;Protein Tyrosine Kinase;pseudotoxoplasmosis syndrome;Publications;Rare Diseases;Reporting;response;Series;Signal Pathway;Signal Transduction;Site;small molecule inhibitor;STAT protein;STAT1 gene;TANK-binding kinase 1;Testing;Therapeutic;Therapeutic Studies;therapy development;Time;Tissues;upstream kinase

PROJECT_TITLE: Efficacy and mechanisms of anti-IFN drugs in AGS treatment

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: GM

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: HOUSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: HLA genes are key mediators of the immune response in humans and have been linked to several hundred autoimmune disorders, inflammatory conditions, infectious diseases, and neurological disorders that can have significant consequences for patients. Despite rapidly amassing sequencing data on millions of people, scientists are limited in their ability to gain clinically meaningful insights about the role of HLA genes in disease due to the lack of appropriate computational tools. We will address this gap by developing a robust and well-supported HLA analysis toolkit that can scale to millions of individuals, thereby enabling researchers to discover novel HLA-disease associations that will drive the development of new preventive and therapeutic approaches.

PI_NAMEs: SHUKLA, SACHET ASHOK (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Acute;Adoption;age related;Alleles;Architecture;Autoimmune Diseases;Autoimmunity;Benchmarking;Biological Response Modifiers;Blood Cells;Cardiovascular Diseases;Cell Line;Clinical;clinically relevant;Communicable Diseases;Communities;Computational algorithm;Computer software;computerized tools;Data;data curation;data format;Data Set;Detection;Development;Disease;Ensure;Ethnic Population;exome sequencing;Family;Genes;genetic variant;Genetic Variation;Genome;genome analysis;genome sequencing;genome wide association study;genomic data;genomic locus;genomic variation;Genomics;Germ Lines;Germ-Line Mutation;Goals;Health;Hematopoiesis;HLA Antigens;Human;Immune;Immune response;Immune System Diseases;Immunity;improved;Individual;Infection;Inflammatory;Infrastructure;insertion/deletion mutation;insight;interoperability;Language;large datasets;Lead;Libraries;Link;Linkage Disequilibrium;mortality;Mutation;Mutation Detection;Myeloid Leukemia;Nature;Nervous System Disorder;next generation sequencing;novel;organ transplant rejection;Patients;Performance;Persons;Pharmaceutical Preparations;Population;Preventive;Process;progression risk;Publications;Reference Standards;reproductive;Research;Research Personnel;Resolution;response;Role;Running;Sampling;Scientist;Somatic Mutation;Testing;Therapeutic;tool;Validation;Variant;variant detection

PROJECT_TITLE: Computational toolkit for robust detection of genomic variation in human leukocyte antigen genes

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Pregnancy;Prevention;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Rates of severe maternal morbidity are rising in the U.S. and disparities in these outcomes are worsening. Telehealth utilization increased dramatically in response to the COVID-19 pandemic and has great potential to reduce severe maternal morbidity and disparities in severe maternal morbidity through increasing prenatal and postpartum care access and utilization. This community engaged mixed methods project will determine the impact of telehealth on severe maternal morbidity and disparities in severe maternal morbidity, and identify best practices for implementation of telehealth to reduce these outcomes.

PI_NAMEs: CANIGLIA, ELLEN CHRISTINA (contact);MATONE, MEREDITH

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Accidents;Address;Age;Birth;Black Populations;Black race;candidate identification;care delivery;Caring;Child Care;Cities;Clinical;Code;Communities;community advisory board;community engagement;Complex;Computer software;Consensus;Country;COVID-19 pandemic;Data;Databases;Death Rate;Detection;Disability status;disparities in morbidity;Disparity;disparity reduction;Early Diagnosis;Eclampsia;effective intervention;Effectiveness;Environment;Equity;Ethnic Origin;Event;experience;Feeling suicidal;First Pregnancy Trimester;flexibility;Geography;Goals;Guidelines;health care availability;health care service utilization;health disparity;Health Insurance;Health Services Accessibility;high risk;Hybrids;improved;Income;Individual;innovation;Intervention;Interview;Knowledge;Lived experience;marginalized population;Maternal Health;Maternal Health Services;maternal morbidity;Maternal Mortality;maternal safety;Medicaid;Medical;Mental Health;Mental Health Services;Methodology;Methods;Modality;Morbidity - disease rate;multidisciplinary;novel;Outcome;Overdose;patient subsets;Patients;Persons;Pharmaceutical Preparations;Philadelphia;physical conditioning;Policies;post pregnancy;postpartum care;Postpartum Period;Pregnancy;pregnancy related death;pregnant;prenatal;Prenatal care;programs;Provider;Quality of Care;Race;racism;Recommendation;Research;Research Methodology;Resources;response;Review Committee;Risk;Risk Reduction;Role;Safety;safety outcomes;satisfaction;Schedule;screening;Self-Injurious Behavior;severe maternal morbidity;social;social health determinants;suicidal;Survivors;telehealth;telehealthcare;transportation access;United States;uptake;Visit;Work

PROJECT_TITLE: The impact of and path forward for telehealth on reducing disparities in severe maternal morbidity: A community engaged mixed-methods study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Patient Safety;Prevention;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Men who have sex with men (MSM) are at high risk for gonorrhea and chlamydia in Kenya, where nucleic acid amplification testing is not feasible and most infections therefore go undiagnosed. We propose an open-label randomized clinical trial with 2900 participants assigned to WHO-recommended periodic presumptive treatment (PPT) or doxycycline post-exposure prophylaxis (doxyPEP), compared to standard syndromic treatment, with 18 months of follow-up and rigorous culture-based and molecular analysis of antimicrobial resistance in Neisseria gonorrhoeae. This work will provide critical data needed to inform guidelines and improve STI control among MSM in sub-Saharan Africa and other resource-limited settings, including modelled estimates of the health and economic impact of scaling up these two interventions on STI control among MSM and their partners in Kenya.

PI_NAMEs: GRAHAM, SUSAN MARIE (contact);SANDERS, EDUARD

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: acceptability and feasibility;Adherence;Adverse event;Africa;Africa South of the Sahara;African;Anal Sex;Antimicrobial Resistance;Bisexual;Caring;Chlamydia;Chlamydia trachomatis;cis-male;Clinic;Clinical;Clinical Trials;Clinical Trials Design;condomless anal sex;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;Data;Development;Diagnosis;Doxycycline;economic impact;Effectiveness;effectiveness evaluation;efficacy evaluation;Epidemiology;experience;follow-up;France;Friends;Gays;Gonorrhea;Guidelines;Health;high risk men;HIV;HIV Infections;Hour;implementation framework;implementation science;improved;Infection;infection burden;Infection Control;infectious disease model;Intervention;intervention cost;Intervention Trial;Kenya;Laboratories;Lead;Measures;men who have sex with men;Modeling;Molecular Analysis;Morbidity - disease rate;multidisciplinary;Mutation;Neisseria gonorrhoeae;Nucleic Acid Amplification Tests;open label;Outcome;Participant;Patients;Periodicals;Pharyngeal structure;point of care;point-of-care diagnostics;Population;pressure;Prevalence;Proctor framework;Productivity;Prophylactic treatment;Provider;Public Health;Publishing;randomized, clinical trials;Recommendation;Rectum;Reporting;Reproductive Health;Research;Research Methodology;Resource-limited setting;Resources;Risk;Safety;Sampling;scale up;Science;Sexual Health;Sexual Partners;Sexually Transmitted Diseases;Societies;standard care;standard of care;Study models;Syphilis;Target Populations;Technology;Testing;transmission process;Treponema pallidum;tv watching;United States;Universities;Unsafe Sex;Update;Urethra;Washington;Work

PROJECT_TITLE: WHO-recommended Periodic Presumptive Treatment versus Doxycycline Post-Exposure Prophylaxis for STI Control among Cisgender Men Who Have Sex with Men in Kenya

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Pediatric;Prevention;Screening and Brief Intervention for Substance Misuse;Substance Misuse;Underage Drinking

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Emerging adults (age 18-25) who frequently use cannabis are at an increased risk for cannabis-related problems and developing cannabis use disorder (CUD). Brief interventions (BIs) have been the gold-standard for heavy and problematic alcohol use in emerging adults; however, evidence is mixed, and the quality of studies is low for similar brief interventions targeting frequent cannabis use, suggesting additional rigor is needed to develop and test potentially efficacious cannabis brief interventions. The goal of the proposed study is to develop and evaluate the feasibility, acceptability, and preliminary efficacy of a novel cannabis brief intervention targeting theory- and empirically-based mechanisms associated with frequent cannabis use in emerging adults.

PI_NAMEs: GEX, KATHRYN  (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: active control;addiction;Address;Age;age group;Alcohol abuse;Alcohol consumption;behavior change;Behavior Therapy;Behavioral;Behavioral Mechanisms;Behavioral Model;brief alcohol intervention;brief intervention;Cannabis;career;career development;clinical implementation;Data;design;Development;DSM-V;Early Intervention;efficacious intervention;Eligibility Determination;emerging adult;Empirical Research;Enrollment;Evaluation;experience;feasibility testing;feasibility trial;Feedback;follow-up;Future;Glean;Goals;Grant;Heavy Drinking;high risk;improved;Individual;innovation;Intervention;intervention delivery;intervention refinement;Intervention Trial;Interview;Legal;Link;Logistics;Manuals;marijuana use;marijuana use disorder;Medical;meetings;Mentored Patient-Oriented Research Career Development Award;Mentorship;Meta-Analysis;multidisciplinary;National Institute of Drug Abuse;novel;Outcome;Participant;patient oriented research;peer;Persons;Population;Positioning Attribute;post intervention;prevent;Prevention;preventive intervention;Procedures;Process;programs;protocol development;Protocols documentation;psychologic;Psychological reinforcement;Qualitative Research;Randomized;randomized trial;recruit;Reporting;Research;Research Activity;Research Methodology;Research Personnel;Risk;Risk Factors;Sampling;Science;secondary analysis;secondary outcome;Series;skills;social;Social Problems;South Carolina;Strategic Planning;Structure;substance use;Substance Use Disorder;Testing;theories;therapy development;Training;Training Activity;Translating;trial design;United States National Institutes of Health;Universities;university student;uptake;Washington;Writing

PROJECT_TITLE: Development of a Novel Cannabis Brief Intervention for Frequently-Using Emerging Adults

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: ALBANY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ALBANY MEDICAL COLLEGE

ORG_STATE: NY

PHR: NARRATIVE. Inhalation of Francisella tularensis causes significant morbidity and mortality in humans. We have used mouse and rabbit models to identify the single most effective tularemia vaccine (S4ΔaroD). In this application we extend these efforts to a non-human primate model against pneumonic tularemia. We expect the results to support advancement of this vaccine and to set the stage for human clinical trials

PI_NAMEs: BARRY, EILEEN M.;HAZLETT, KARSTEN R.O. (contact);REED, DOUGLAS SCOTT

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Advanced Development;aerosolized;Aerosols;animal rule;Attenuated Vaccines;Bacteriology;Biometry;clinical translation;Clinical Trials;Data;Data Correlations;Dose;efficacy evaluation;efficacy trial;Engineering;experimental study;Fever;Fostering;Francisella tularensis;Frustration;Future;Goals;head-to-head comparison;Human;human pathogen;Immunization Programs;Inbreeding;Individual;Laboratories;Lead;Macaca;Mediating;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;mutant;nonhuman primate;Oryctolagus cuniculus;Outcome;Plasma;Positioning Attribute;Productivity;Publications;Pulmonary tularemia;Resources;response;Rodent;Rodent Model;Sampling;Secure;Surrogate Markers;Testing;Translating;Translations;Tularemia;Vaccinated;Vaccination;vaccine candidate;vaccine efficacy;vaccine evaluation;Vaccine Research;Vaccines;vaccinology;Virulent;Zoonoses

PROJECT_TITLE: Translation of a highly protective tularemia vaccine to the NHP model

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ORG_CITY: MILWAUKEE

ORG_DEPT: NEUROSURGERY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Degenerative cervical myelopathy (DCM) is a widespread and debilitating condition and decompressive surgery, the standard treatment for DCM, fails to provide any meaningful clinical recovery in over 30% of patients while over 40% have a residual disability. This proposal is important and impactful because it uses a unique model of DCM in combination with our team's expertise in dissecting neural networks to delineate for the first time the neural basis of forelimb deficits and recovery in DCM. This proposal will determine if targeted neuromodulation of spinal interneurons will enhance neurological recovery after decompressive surgery.

PI_NAMEs: SATKUNENDRARAJAH, KAJANA  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;Adult;Affect;Anatomy;Animal Model;behavior test;Cervical;Cervical spinal cord structure;Chronic;Clinical;clinically relevant;Compensation;Cutaneous;Data;design;Development;dexterity;disability;Disabling;Dorsal;efficacy evaluation;Electrophysiology (science);Equilibrium;Forelimb;Functional disorder;functional improvement;functional outcomes;functional plasticity;Gait abnormality;Genetic;genetic approach;Goals;grasp;Hand;hand dysfunction;Hand functions;Hindlimb;Impairment;improved;Individual;Interneurons;kinematics;Knowledge;Manuals;Maps;Modeling;Molecular Genetics;Motor;motor control;Motor Cortex;motor disorder;motor function recovery;Motor Neurons;motor recovery;mouse model;Mus;Neonatal;neural;neural circuit;neural network;Neuroanatomy;neurological recovery;Neuronal Plasticity;Neurons;neuroregulation;novel;novel therapeutic intervention;older adult;Operative Surgical Procedures;optogenetics;Outcome;Output;Pain;Patient-Focused Outcomes;Patients;Peripheral;Play;Population;postoperative recovery;presynaptic;Quality of life;Recovery;Recovery of Function;Reporting;Residual state;Role;Sensorimotor functions;Sensory;sensory input;Spinal;Spinal Cord;spinal cord compression;Spinal Cord Diseases;Spinal cord injury;spinal cord surgery;standard care;surgery outcome;Surgical Decompression;Testing;Therapeutic;therapy development;Time;Transgenic Mice;treatment strategy;Upper Extremity;Vertebral column;Viral;Work

PROJECT_TITLE: Dissecting spinal interneuron circuits to augment neurological recovery in Degenerative Cervical Myelopathy (DCM)

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative:  Preclinical models of lung cancer are essential tools for researchers to understand cancer biology and develop therapeutic strategies, but how they compare with each other and align with human tumors remains elusive. This study proposes to collect and harmonize molecular and pathology data from a wide range of lung cancer preclinical models. These data will be used to generate a user-friendly web application with a myriad of informatics tools for the broad lung cancer community to explore and assess whether preclinical models faithfully represent patient tumors in multiple aspects.

PI_NAMEs: CAI, LING  (contact)

PROGRAM_OFFICER_NAME: BENAVIDEZ, JUSTIN MICHAEL

PROJECT_TERMS: Address;Agreement;Algorithmic Analysis;Algorithms;analysis pipeline;analytical tool;anti-cancer research;Biological Process;Cancer Biology;Cancer Patient;Cell Communication;Cell Extracts;Cell Line;Cell Nucleus;Cells;Chemicals;Classification;Clinical Data;cohort;Communities;comparative;cost effective;Data;Data Analyses;data exploration;data integration;data resource;Data Set;Databases;Deposition;digital;Ensure;experimental study;feature extraction;Feedback;Gene Expression;Genes;Genetic Engineering;Goals;Growth;Histopathology;Human;Image;Image Analysis;image archival system;improved;in vivo Model;Individual;Informatics;informatics tool;Lung;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Modeling;Molecular;Molecular Profiling;mouse model;Mutate;outcome prediction;Pathologic;Pathology;pathology imaging;patient derived xenograft model;Patients;Pattern;Phenotype;pre-clinical assessment;Pre-Clinical Model;Process;public repository;Publishing;Quality Control;Research Personnel;Resource Sharing;Resources;response;Sampling;small cell lung carcinoma;Stains;Standardization;Statistical Methods;targeted treatment;Therapeutic;Tissue-Specific Gene Expression;tool;transcriptomic profiling;transcriptomics;Translations;tumor;tumor heterogeneity;tumor microenvironment;user-friendly;validation studies;web app

PROJECT_TITLE: Construction of A Lung Cancer Preclinical Model Cross-comparison Platform

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-E (55)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: IRVINE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Cell-cell communication is one of the most fundamental, yet poorly understood problems in modern biology. The proposed work will combine mathematical modeling and machine learning to develop analysis tools for systematic screening of cell-cell communication using spatial transcriptomic data. The results will be directly relevant to understanding of tissue organization in space, the mechanisms of microenvironment for tumors, developmental processes, and cell fate decision.

PI_NAMEs: CANG, ZIXUAN ;NIE, QING  (contact)

PROJECT_TERMS: Accounting;Address;Agonist;antagonist;Area;Awareness;Benchmarking;Biological;Biological Process;Biology;Cell Communication;Cell model;Cell Size;Cells;Cellular Structures;Characteristics;Classification;cofactor;Communication;Complex;computer framework;computerized tools;Computing Methodologies;Data;Data Analyses;deep learning;Developmental Process;Dimensions;Gene Expression;Generations;Genes;genomic data;genomic profiles;Graph;graph neural network;Group Processes;Heterogeneity;Human;improved;Individual;innovation;insight;Knowledge;Ligands;Link;Location;Machine Learning;Maps;mathematical methods;mathematical model;Measures;Mediating;Methods;Modeling;Modernization;Molecular;multi-scale modeling;Mus;neglect;novel;open source;Output;Pathway Analysis;Pattern;Pattern Recognition;physical model;Preservation Technique;Process;Proteins;rapid growth;receptor;Regulation;Resolution;screening;Signal Transduction;single cell genomics;single-cell RNA sequencing;Spatial Distribution;Spottings;success;System;Systems Biology;Techniques;Technology;Tissues;tool;tool development;transcriptome;transcriptomics;tumor microenvironment;Work

PROJECT_TITLE: Development of tools for analyzing cell-cell communication using spatial transcriptomic data

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Narrative This project investigates rapid plasticity of interneuron intrinsic excitability as an important mechanism for experience-dependent plasticity and homeostasis in cerebral cortex. It will identify the molecular mechanisms for plasticity of intrinsic excitability in two interneuron classes, PV and SST cells, and will test whether deficits in this process contribute to inhibitory deficits in autism. This basic research could identify novel therapeutic targets for restoring cortical circuit function in severe genetic forms of autism.

PI_NAMEs: FELDMAN, DANIEL  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Affect;autism spectrum disorder;Basic Science;Brain-Derived Neurotrophic Factor;Cell Nucleus;Cells;Cerebral cortex;Code;critical period;D Cells;Data;Dependence;deprivation;Disease;ErbB4 gene;experience;Failure;FMR1 gene;Functional disorder;Gene Expression;Gene Expression Regulation;Gene Mutation;Genes;Genetic;Grant;Homeostasis;Immunohistochemistry;Impairment;Induced Neurons;Interneurons;Learning;Mediating;Messenger RNA;model of autism spectrum disorder;Molecular;molecular marker;mouse model;Mus;neural;Neurons;new therapeutic target;novel;novel therapeutic intervention;NRG1 gene;NRG3 gene;Output;Parvalbumins;Pathway interactions;pharmacologic;Pharmacology;Physiology;Play;Potassium;Prevalence;Process;Property;protein expression;Proteins;Pyramidal Cells;Regulation;response;restoration;Role;selective expression;Sensory;sensory cortex;Sensory Deprivation;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Somatosensory Cortex;Somatostatin;Structure;Techniques;Testing;tool;Transcriptional Regulation;transcriptome sequencing;Transgenic Mice;Vibrissae;voltage;voltage clamp;Work

PROJECT_TITLE: Sensory regulation of interneuron intrinsic excitability in sensorycortex

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Emerging Infectious Diseases;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vaccine Related - AIDS;Vector-Borne Diseases

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: RELEVANCE (See instructions): Genetically diverse pathogens including HIV-1, dengue virus, Plasmodium falciparum (malaria), and SARS-CoV-2 incur large economic and health burdens that can be majorly ameliorated by preventive vaccines and broadly neutralizing monoclonal antibodies. This project develops innovative statistical methods for randomized efficacy trials of vaccines and monoclonal antibodies, for understanding how the protection of these modalities depends on immunological biomarkers and pathogen features.

PI_NAMEs: GILBERT, PETER B. (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: 2019-nCoV;Accounting;Acquired Immunodeficiency Syndrome;Address;Advanced Development;Amino Acid Sequence;Amino Acids;Antibodies;Automobile Driving;Biological Markers;Blood;causal model;circumsporozoite protein;Clinical;Clinical Trials;COVID-19;COVID-19 vaccine;Data;Data Analyses;deep sequencing;Dengue;Dengue Vaccine;Dengue Virus;design;Development;Disease;Drug Kinetics;Dryness;Economics;efficacy evaluation;efficacy study;efficacy trial;Etiology;Event;Failure;Genetic;Genetic Variation;Goals;Health;Health Care Costs;HIV Vaccine Trials Network;HIV-1;HIV-1 vaccine;Human;Immune;Immune response;Immunity;Immunologic Markers;Immunologics;Immunophenotyping;improved;Individual;Infection;Infection prevention;innovation;insight;Instruction;interest;Intervention;Investigation;Joints;Limes;Malaria;malaria infection;Malaria Vaccines;Measurement;Measures;Mediating;Methods;Modality;Modeling;Monoclonal Antibodies;neutralizing monoclonal antibodies;Outcome;pathogen;Pattern;Phenotype;Plasmodium falciparum;Population;pre-exposure prophylaxis;prevent;Prevention;prevention efficacy trial;Preventive vaccine;process improvement;Proportional Hazards Models;protein aminoacid sequence;Protein C;Randomized;Randomized, Controlled Trials;Recurrence;Regimen;Research;response biomarker;Risk;Sampling;Serum;Spottings;Statistical Methods;Stratification;study population;Surrogate Endpoint;Time;tool;Vaccination;vaccine candidate;vaccine development;vaccine efficacy;vaccine immunogenicity;vaccine trial;vaccine-induced antibodies;Vaccines;Viral;Virus

PROJECT_TITLE: Statistical Methods for Efficacy Trials of Vaccines and Monoclonal Antibodies Against Genetically-Diverse Pathogens

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biotechnology;Cancer;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Standard cancer cell lines have had an important impact on cancer research and greatly facilitated development of a variety of cancer treatments. However, new mammalian cancer culture models are difficult to establish. We developed a new cell culture system that allows us to establish cancer cell cultures that retain the accurate molecular features and patient outcome and drug response profile; in this application we propose to implement this technology and compare monolayer and organoid models and PDX from the same patient to establish best practices in the use of these models.

PI_NAMEs: INCE, TAN A. (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Achievement;Address;Adherent Culture;anti-cancer research;Antibiotics;Antineoplastic Agents;Biochemical Reaction;Breast;cancer cell;Cancer cell line;Cancer Model;cancer therapy;cancer type;Capital;Cardiac Glycosides;Cell Culture System;Cell Culture Techniques;cell growth;Cell Line;Cell model;Cell Proliferation;Cells;chemotherapy;Clinic;Coculture Techniques;Combined Modality Therapy;Communicable Diseases;cost;Credentialing;Culture Media;cytokine;Data;Data Set;Development;Disease;drug development;drug discovery;Epithelium;expectation;experimental study;Fibroblasts;fighting;Fine needle aspiration biopsy;Genome;Genotype;Goals;Growth;Growth Factor;Histologic;Human;improved;Individual;Infectious Agent;innovation;Institution;Investments;Kidney;leukemia;Life;Liquid substance;longitudinal analysis;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Mammalian Cell;Manuscripts;Metabolic;Methods;Modeling;Molecular;Molecular Profiling;monolayer;Muscarinic Agonists;Mutation;neoplastic cell;Normal Cell;Nutrient;Organoids;Outcome;Ovarian Adenocarcinoma;Ovary;pathogen;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phenotype;precision oncology;Preparation;Proliferating;Prostate;Proteome;Publishing;Reagent;Renal Carcinoma;repository;Research;Research Personnel;Residual Neoplasm;response;Sampling;Serum;Solid Neoplasm;Stromal Cells;success;System;targeted treatment;Techniques;Technology;Testing;Time;Tissues;transcriptome;treatment response;tumor;Tumor Tissue;Valine;Visceral metastasis;Vitamin A;Xenograft procedure

PROJECT_TITLE: Culture of tumor versus normal cells


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_NAME: ALLEN INSTITUTE

PHR: Project Narrative This project aims to build a structure-function taxonomy of two key groups of neuromodulatory neuron types in the brain: neurons that release serotonin and those that release norepinephrine. Our co-laboratory will combine molecular, genetic, electrophysiological, morphological, and behavioral measurements to classify subtypes of serotonin and norepinephrine neurons and map their functions across the brain.

PI_NAMEs: CHANDRASHEKAR, JAYARAM ;COHEN, JEREMIAH YAACOV (contact);LEE, BRIAN ROBERT

PROGRAM_OFFICER_NAME: YAO, YONG

PROJECT_TERMS: Amygdaloid structure;Anatomy;Area;Atlases;Axon;Bar Codes;Basal Ganglia;Behavior;behavior measurement;Behavioral;biophysical properties;Brain;Cell Physiology;cell type;Cells;Cerebellum;Characteristics;Classification;clinical application;Data;Decision Making;Dorsal;Drug usage;electrical property;Electrophysiology (science);Engineering;Enhancers;Equipment and supply inventories;experimental study;extracellular;falls;Fiber;frontal lobe;Gene Expression;Genetic;Goals;in vivo;Individual;Laboratories;Learning;Link;Location;locus ceruleus structure;Maps;Measurement;Measures;Membrane Potentials;Methods;Molecular;molecular marker;Morphology;multimodality;multiscale data;Mus;nerve supply;neural;neural circuit;Neurons;neuropsychiatric disorder;neuroregulation;neurotransmitter release;Norepinephrine;patch sequencing;Pattern;Photometry;Physiological;Positioning Attribute;Reagent;reconstruction;Rewards;Serotonergic System;Serotonin;serotonin receptor;Signal Transduction;single-cell RNA sequencing;Site;Structure;System;Taxonomy;Techniques;Testing;Thalamic structure;tool;transcriptomics;Uncertainty;Virus;Work

PROJECT_TITLE: Structure-function cell atlas for norepinephrine and serotonin neurons

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (06)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative We propose a novel joint parametric reconstruction framework to improve the estimation of drug receptor occupancy and half-maximum blocking effect from PET receptor occupancy studies. The goal is to reduce the sample size required to characterize central nervous system drugs and therefore facilitate drug development.

PI_NAMEs: MARIN, THIBAULT  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Address;Anatomy;Animals;Binding;Brain;Central Nervous System Agents;Central Nervous System Diseases;CHRM4 gene;Clinical Trials;cohort;cost;Data;deep learning;denoising;denoising deep learning;Development;Dose;drug development;drug efficacy;Drug Evaluation;Drug Receptors;Drug Targeting;efficacy evaluation;Ensure;Exhibits;Goals;Image;image reconstruction;Imaging Device;improved;in vivo;Injections;Joints;kinetic model;Kinetics;Ligands;Link;Logistic Models;Logistics;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methods;Modeling;Motion;Noise;nonhuman primate;novel;Performance;Pharmaceutical Preparations;Pharmacologic Substance;Phase;positive allosteric modulator;Positron-Emission Tomography;Primates;Process;receptor;reconstruction;response;Sample Size;Scanning;Series;simulation;Spatial Distribution;tool;Tracer

PROJECT_TITLE: Improved drug efficacy assessment using joint Bayesian estimation framework

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases;West Nile Virus;Zika Virus

ORG_CITY: ATLANTA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative The overarching goal of this application is to develop mRNA-encoded Cas13 based drugs for treating flaviviruses, with a focus on dengue and West Nile virus, but including screens against yellow fever, Powassan and Zika viruses. Multiple Cas13 nucleases will be evaluated, and mechanisms of action investigated; efficacy will be demonstrated with dengue (serotypes 1-4) and West Nile virus in rodent infection models. Overall, we feel this approach and the RNA-based platform have the potential to alter the paradigm for how viral infections are treated.

PI_NAMEs: BRINTON, MARGO A;SANTANGELO, PHILIP J (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: 2019-nCoV;Address;Anti-viral Agents;antiviral drug development;Binding;Biotechnology;Blood Vessels;Cells;Chemistry;compare effectiveness;Congenital Abnormality;Data;Dengue;Dengue Virus;Dengvaxia;Development;Disease;Dose;Down-Regulation;Drug Delivery Systems;drug efficacy;emerging virus;Encephalitis;Enzymes;epidemic virus;FDA approved;Flavivirus;Flavivirus Infections;Formulation;functional outcomes;Gene Transduction Agent;Goals;Guide RNA;Hepatitis;Immunofluorescence Immunologic;improved;In Vitro;in vivo;in vivo Model;Infection;Influenza;innovation;Japanese encephalitis virus;Life Cycle Stages;lipid nanoparticle;Messenger RNA;Modeling;mouse model;mRNA delivery;Mus;Myelogenous;Nature;neurotropic;neutralizing antibody;nuclease;Paralysed;pathogen;Pathogenicity;Persons;Pharmaceutical Preparations;Population;Powassan virus;prevent;Publications;Qualifying;Research;Resistance;response;Ribonucleases;RNA;RNA Degradation;RNA Viruses;Rodent;Safety;Seasons;Serotyping;Shock;single molecule;small molecule;solid state;superresolution imaging;Syndrome;Tick-Borne Encephalitis Virus;Time;transcriptome sequencing;Universities;Vaccination;Vaccines;Variant;vector-borne;Viral;viral RNA;virology;Virus;Virus Diseases;Visceral;West Nile viral infection;West Nile virus;Work;Yellow Fever;Yellow fever virus;Zika Virus

PROJECT_TITLE: Treating flaviviruses with mRNA-encoded Cas13

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AIRT-J (01)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

PHR: Public Health Relevance. While CT remains the most highly utilized diagnostic tool in clinical practice, its technology still calls for research and development along the entire imaging chain to improve diagnostic accuracy and patient outcomes. The clinical translation of such developments must be safe, efficient, and timely; however, it remains a challenge to the community how to precisely predict performance during and after the development phase. Our proposal aims to develop 3D printing hardware and software that will be capable of creating patient-based phantoms with accurate spectral x-ray characteristics and a natural look and feel of anatomical and pathological structures.

PI_NAMEs: NOËL, PETER B (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TITLE: PixelPrint: a 3D printing platform for creating lifelike patient-based CT phantoms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-C (03)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Clinical Research;Lung;Machine Learning and Artificial Intelligence;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury that allows fluid to leak into the lungs and makes breathing difficult, killing 74,000 people each year in the United States. In this project, a highly interdisciplinary team of engineers, clinicians, and data scientists is developing a portable, non-invasive breathalyzer-type device and corresponding algorithm to quickly diagnose ARDS, and the device can be attached to ventilators so a patient can be continuously monitored even if they cannot breathe on their own. Because the device will detect ARDS much more accurately than is currently possible and will help determine if patients are getting better or worse, it is expected to improve clinical decision making and enable earlier treatment, thus improving outcomes for those suffering from ARDS.

PI_NAMEs: FAN, XUDONG  (contact);SJODING, MICHAEL WILLIAM;WARD, KEVIN

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: acute hypoxemic respiratory failure;Acute Respiratory Distress Syndrome;Address;adjudication;Adult;Algorithms;Artificial Intelligence;Berlin;Biological Markers;biomarker signature;Biomedical Engineering;Breathing;Clinical;clinical decision-making;clinical diagnosis;Clinical Markers;clinical predictors;Complex;cost;Critical Care;Data;Data Science;Data Scientist;Decision Making;density;Detection;Development;Devices;Diagnosis;Disease;Early treatment;Engineering;Ensure;Evidence based treatment;Exhalation;Exhibits;Functional disorder;gas analyzer;Gas Chromatography;Goals;Hypoxemic Respiratory Failure;improved;improved outcome;Inflammatory;inflammatory marker;innovation;insight;Intubation;Life;Liquid substance;longitudinal, prospective study;Lower respiratory tract structure;Lung;Lung Diseases;lung injury;Machine Learning;Measurement;Measures;Metabolic Marker;Metabolism;metabolomics;molecular diagnostics;Monitor;Morbidity - disease rate;mortality;Nitric Oxide;novel;Organ;Outcome;Patient Recruitments;Patient-Focused Outcomes;Patients;Pattern;Performance;Persons;Physicians;Physiological;point of care;portability;Predisposition;Process;Prognosis;prognostic;prospective;prototype;recruit;Resolution;Sampling;Series;Signal Transduction;System;Technology;Testing;Time;treatment response;United States;vapor;Ventilator;Volatilization;Work

PROJECT_TITLE: Point-of-care micro-gas chromatography device for diagnosis and monitoring of acute respiratory distress syndrome using exhaled breath signatures

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Hematology

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Project Narrative: The training of future researchers in hematology is tremendously important to the development of the next generation of treatments for blood diseases. This training grant is especially important for training physicians and scientists that will study clinical problems related to bleeding, abnormal blood clot formation (deep vein clots, heart attacks, and strokes), low blood counts and bone marrow failure, inflammation, immune therapy of blood-based cancers and stem-cell based therapies.

PI_NAMEs: SHEEHAN, JOHN PATRICK (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Hematology;Research Training

PROJECT_TITLE: Research Training in Hematology

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM (OA)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Complementary and Integrative Health;Lymphatic Research;Mental Health;Neurosciences;Pain Research;Prevention

PHR: Chronic stress, the consistent sense of feeling pressured and overwhelmed, is pervasive in our society and has been linked to increased risk of cardiovascular diseases, mental health problems, neuropathic pain and shorter life expectancy. Current treatment options include changes in lifestyle, exercise, anxiolytics, improved sleep and more, but these options are clearly not sufficient, since chronic stress contributes to the increasing societal burden of alcohol and drug abuse, unemployment and collapse of family structures. In this application we test the idea that chronic stress impairs several cellular restorative processes that normally allow our brain to be ready for the daily challenges of our waking life. These restorative processes involve the two major types of brain cells, astrocytes and neurons, and together allow to remove metabolic toxic products and to maintain the high energy costs of brain activity under control. In the proposed experiments we will study astrocytes and neurons in parallel to understand how the normal brain recovers from the wear and tear of our waking activities, and how chronic stress impairs this recovery process.

PI_NAMEs: CIRELLI, CHIARA  (contact);NEDERGAARD, MAIKEN

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Acoustic Stimulation;Acute;Alcohol abuse;Animals;Anti-Anxiety Agents;Astrocytes;behavior measurement;Behavioral;Biological;Biological Markers;Biology;Blood Vessels;Brain;brain cell;cardiovascular disorder risk;Cell Physiology;cell type;cellular targeting;Chronic Disease;Chronic stress;Clinical Research;Complex;cost;Darkness;Drug abuse;Electroencephalography;Electron Microscopy;Exercise;experimental study;Face;family structure;Feeling;Functional disorder;Future;Glycogen;glymphatic clearance;glymphatic dysfunction;glymphatic system;Heart Rate;Homeostasis;Hour;Human;Hypersensitivity;Impairment;improved;improvement on sleep;insight;Learning;Life;Life Expectancy;Life Style;Light;Link;Liquid substance;locus ceruleus structure;Lymphatic;Measures;Mechanics;Memory;Mental Health;Metabolic;Modeling;mouse model;Mus;Neuroglia;Neuromodulator;Neurons;Nonpharmacologic Therapy;noradrenergic;Norepinephrine;novel;optogenetics;Output;Pain;pain sensitivity;Pain Threshold;painful neuropathy;Pattern;Performance;Phase;Physiological;pressure;prevent;Process;Quality of life;Recovery;restoration;Risk;Risk Reduction;Rodent;Scanning Electron Microscopy;sensor;Sleep;social defeat;Societies;Structure;Synapses;Testing;tool;Unemployment;vasomotion;Wakefulness;wasting

PROJECT_TITLE: Disruption of restorative processes in chronic stress: An integrated cellular approach

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative The intracellular pathogen Shigella flexneri is the causative agent of Bacillary dysentery, a severe form of diarrheal disease associated with massive destruction of the intestinal mucosa and presence of blood in stool. In this proposal, we present our plans to uncover the role of host factors in the infant rabbit model of shigellosis recently developed by our laboratory. The proposed approach will contribute to our general understanding of the mechanisms underlying microbial pathogenesis and may constitute the foundation for the rational design of preventive and therapeutic interventions.

PI_NAMEs: AGAISSE, HERVE F (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Actins;Acute;acute infection;Adult;Affect;Age;Animal Model;Antibiotic Therapy;Antimicrobial Resistance;Back;Bacteria;Blood;Blood Vessels;Cell Death Inhibition;cell type;Cells;Cellular biology;Cessation of life;Child;Colon;Cytoskeleton;Cytosol;Data;Dendritic Cells;design;Development;diarrheal disease;Disease;Dose;Dysentery;enteric pathogen;Epithelial Cells;Epithelium;experience;Feces;Foundations;Gene Expression Profile;Hemorrhagic colitis;Human;Human Volunteers;Immune;immune cell infiltrate;Immune response;In Vitro;Individual;Infant;Infection;Infection Control;Integration Host Factors;Intestinal Mucosa;Intestines;Invaded;Knowledge;Laboratories;Lamina Propria;Lesion;M cell;Macrophage;Mainstreaming;Mediating;microbial;Modeling;Molecular;Motility;Mucous Membrane;neutrophil;Neutrophil Infiltration;nonhuman primate;Oral;Oryctolagus cuniculus;pathogen;Pathogenesis;pathogenic bacteria;Patients;Phagocytes;Pharmaceutical Preparations;Phase;Population;preventive intervention;Process;Publishing;rational design;resistant strain;Resolution;response;Risk;Role;Route;Seminal;Shigella flexneri;Shigella Infections;Side;Small Intestines;Supporting Cell;Symptoms;System;Therapeutic Intervention;tissue culture;tissue regeneration;Tissues;transcriptome sequencing;transmission process;Type III Secretion System Pathway;Ulcer;unpublished works

PROJECT_TITLE: Host factors in shigellosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-U (90)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Palliative Care;Rehabilitation

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE The increasingly crucial role played by family and friend caregivers of patients with advanced cancer is complicated by existential distress, but to date, current psychosocial interventions fail to address such distress. This project is relevant to NIH’s mission as it represents a critical step in the refinement of a targeted intervention–Meaning-Centered Psychotherapy for Cancer Caregivers (MCP-C)–that has shown encouraging results in improving caregivers’ sense of meaning in life and spiritual wellbeing and ameliorating anxiety and depression. If successful, MCP-C holds significant promise to not only improve the quality of life for caregivers across the caregiving trajectory from diagnosis through bereavement, but also to yield downstream benefits to the patients for whom they provide care.

PI_NAMEs: APPLEBAUM, ALLISON  (contact)

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: Address;Advance Care Planning;Advanced Malignant Neoplasm;Aftercare;American;Anxiety;Bereavement;cancer care;Caregiver Burden;caregiver quality of life;Caregiver support;Caregivers;caregiving;Caring;Cessation of life;Child Care;Communication;Communities;COVID-19 pandemic;Critical Care;Data;depressive symptoms;Diagnosis;disabled;Discipline of Nursing;Disease;Distress;effective intervention;efficacy evaluation;Emotional;Employment;end of life;experience;Face;Family;Family Caregiver;Family member;Feeling hopeless;follow up assessment;follow-up;Friends;Goals;Grief reaction;healing;Health;Healthcare;high risk;improved;injured;innovation;Intervention;Left;Life;life-limiting cancer;Long-Term Care for Elderly;loved ones;Maintenance;Malignant Neoplasms;Manuals;Meaning and purpose;Mediating;Mediator;Medical;Memorial Sloan-Kettering Cancer Center;Mental Depression;Mental Health;Mission;Outcome;Palliative Care;Participant;Patient Care;Patients;Personal Satisfaction;Persons;Play;Post-Traumatic Stress Disorders;primary endpoint;primary outcome;Proxy;Psychopathology;psychosocial;psychosocial outcome;Psychotherapy;Quality of life;Randomized;Randomized, Controlled Trials;Readiness;Regrets;Reporting;Research;resilience;Risk;Role;screening;secondary outcome;Shoulder;Social support;Solid Neoplasm;Spiritual well-being;success;telehealth;therapy design;Time;treatment arm;treatment as usual;treatment effect;United States;United States National Institutes of Health;Vulnerable Populations;Well in self

PROJECT_TITLE: Meaning-Centered Psychotherapy to Meet Palliative Care Needs of Cancer Caregivers

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Gene Therapy;Genetics;Immunization;Immunotherapy;Prevention;Vaccine Related

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Our study expected to validate novel vaccine in dogs with spontaneous oral melanoma and gain better understanding towards possible use of viral-based immunotherapy in human patients, which has direct relevance to public health.

PI_NAMEs: ASLANIDI, GEORGE V (contact);BORGATTI, ANTONELLA M

PROGRAM_OFFICER_NAME: SALOMON, RACHELLE

PROJECT_TERMS: Achievement;Active Immunization;adaptive immune response;Address;adeno-associated viral vector;Adjuvant;Age;Animal Model;Antigen Presentation Pathway;antigen processing;Antigen Targeting;Antigen-Presenting Cells;Antigens;Basic Science;Biological Assay;Biological Response Modifiers;Biomedical Engineering;cancer immunotherapy;cancer therapy;Cancer Vaccines;Canis familiaris;Capsid;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;chemokine;chemotherapy;clinically relevant;Clone Cells;combinatorial;companion animal;Complex;Cross Presentation;Cutaneous Melanoma;cytokine;Cytomegalovirus;Data;Dendritic Cells;Dependovirus;design;Development;Disease Progression;Dissection;Disseminated Malignant Neoplasm;DNA biosynthesis;DNA cassette;Dopachrome isomerase;dosage;Dose;Dose Limiting;Engineering;Environmental Exposure;Enzyme-Linked Immunosorbent Assay;Equilibrium;experimental study;Flow Cytometry;Functional impairment;Gene Expression Profile;Gene Transduction Agent;Genes;Genetic;Genetic Markers;Heterogeneity;Histocompatibility Antigens Class I;Human;Immune;Immune response;Immune system;immunogenic;immunogenicity;Immunologic Stimulation;immunoregulation;Immunotherapy;improved;in vivo;Individual;Inflammatory Response;Injections;Interferon Type II;Intramuscular;Kinetics;Local Therapy;Malignant Neoplasms;Measures;Melanoma;Melanoma Tumor;Methods;Modeling;Modification;Molecular;Monophenol Monooxygenase;Mouth Neoplasms;mucosal melanoma;Mucous Membrane;multiplex assay;Mutagens;Neoplasm Metastasis;next generation;novel;novel therapeutic intervention;novel vaccines;Nuclear Translocation;Oncologist;Operative Surgical Procedures;Oral;Oral Melanoma;Patients;Persons;Population;pre-clinical;Pre-Clinical Model;preclinical study;Prevalence;Production;programs;Proliferating;promoter;Property;Public Health;Recurrent tumor;Reporting;Research;Resistance;response;Safety;Serine;Serotyping;side effect;Signal Transduction;SILV gene;Site;Surface;T-Cell Proliferation;T-Lymphocyte;Testing;Therapeutic;therapeutic development;Threonine;TNF gene;Toxic effect;trafficking;transduction efficiency;Treatment Failure;Treatment outcome;tumor;Tumor Antigens;tumor diagnosis;Tumor Immunity;Tyrosinase related protein-1;Vaccination;vaccine development;vaccine platform;vaccine strategy;Vaccine Therapy;Vaccines;Valine;vector;Viral;viral DNA;Viral Genome;Virus

PROJECT_TITLE: Development of novel AAV vaccine strategy in a pre-clinical model of oral melanoma.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 TIO-D (01)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE COUNTY

ORG_STATE: MD

PHR: Project Narrative The kappa opioid receptor (KOR) system is a prominent neuromodulatory system that controls various physiological functions such as antinociception and mood perception. The KOR system represents a potential alternative to current opioid analgesics, but aversive side effects of KOR activation have hindered its drug development. The experiments proposed will help identify intracellular signaling events activated by KOR that modulate aversion, which may reveal strategies to separate therapeutic from aversive effects of KOR agonists, potentially leading to novel treatments for pain and affective disorders.

PI_NAMEs: SUTTON, LAURIE  (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Absence of pain sensation;Address;Affect;Agonist;Analgesics;Anhedonia;antagonist G;antinociception;Arrestins;Aversive Stimulus;Behavior;Behavior Control;behavior test;behavioral outcome;behavioral response;Binding;Binding Proteins;Cells;conditional knockout;Data;Desire for food;Development;dopaminergic neuron;drug development;Dynorphins;dysphoria;Enterobacteria phage P1 Cre recombinase;Environment;Equilibrium;Event;Exhibits;experimental study;Family;Future;G Protein-Coupled Receptor Signaling;G-Protein Signaling Pathway;G-Protein-Coupled Receptors;genetic approach;Goals;GTP-Binding Protein Regulators;GTP-Binding Proteins;GTPase-Activating Proteins;Guanosine Triphosphate;Heterotrimeric GTP-Binding Proteins;Home;in vivo evaluation;innovation;invention;kappa opioid receptors;Knock-out;Knockout Mice;Knowledge;Long-Term Effects;Mediating;member;Membrane;Mission;Mood Disorders;Moods;mouse model;Mus;mutant;Names;National Institute of Drug Abuse;negative affect;Neuromodulator;Neurons;neuroregulation;novel;Opioid;Opioid agonist;Opioid Analgesics;Opioid Peptide;Opioid Receptor;Outcome;Pain;Pain Disorder;Pain management;Pathway interactions;Perception;Phosphorylation;Phosphorylation Site;Physiological;platelet protein P47;Population;Property;protein activation;Proteins;Pruritus;Psychoses;Receptor Activation;Receptor Signaling;receptor-mediated signaling;Regulation;Research;response;RGS Proteins;Role;Sedation procedure;sedative;side effect;Signal Induction;Signal Pathway;Signal Transduction;Signaling Protein;System;Testing;theories;Therapeutic;therapeutic development;Therapeutic Uses;Transgenic Mice;Ventral Tegmental Area;Viral;Work

PROJECT_TITLE: Rgs7 regulation of the Kappa Opioid Receptor

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Public Health Relevance Statement: Neuronal communication is largely mediated through the release of small-molecules called neurotransmitters which bind to and activate receptors on neighboring nerve cells. Neurotransmitter molecules are stored into small vesicles at high concentrations by transport proteins which are also targets of therapeutic drugs for neuropsychiatric disorders including hyperkinetic movement disorders such as tardive dyskinesia, Tourette’s syndrome, and Huntington’s disease. The proposed research focuses on how these neurotransmitter transport proteins work and how therapeutic and addictive drugs bind to and modify their activities.

PI_NAMEs: COLEMAN, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: addiction;Affinity;Amphetamines;Anxiety;Architecture;Attention Deficit Disorder;autism spectrum disorder;Behavior;Binding;Binding Sites;Biochemical;Biogenic Amines;biophysical properties;Bipolar Disorder;burden of illness;Carrier Proteins;Cell membrane;Central Nervous System;combat;Communication;Complex;Coupled;Coupling;Cryoelectron Microscopy;Cytosol;Development;Disease;Dopamine;Drug Addiction;Drug Binding Site;drug development;Drug Interactions;Drug Modulation;Drug usage;experimental study;Gilles de la Tourette syndrome;Head;Histamine;Human;Huntington Disease;Hypertension;improved;inhibitor;insight;Investigation;Knowledge;Lead;Ligands;Link;Major Depressive Disorder;Mediating;Medicine;Membrane Transport Proteins;Methodology;Molecular;Molecular Conformation;Movement Disorders;Mutagenesis;Nervous System Disorder;Neuroendocrine Cell;Neurons;neuropsychiatric disorder;neurotransmission;neurotransmitter release;neurotransmitter reuptake;neurotransmitter transport;Neurotransmitters;next generation;Norepinephrine;Outcome;Parkinson Disease;particle;Patients;Peripheral;Peripheral Nervous System;Persons;Pharmaceutical Preparations;Predisposition;presynaptic neurons;prevent;Process;Productivity;Protein Family;Proteins;Protons;public health relevance;receptor;Receptor Signaling;Recycling;Regulation;Research;research and development;Reserpine;Resolution;response;Rewards;Schizophrenia;Serotonin;side effect;Signal Transduction;small molecule;Spasm;Specificity;Structure;Structure-Activity Relationship;Synapses;Synaptic Vesicles;Tardive Dyskinesia;targeted treatment;Tetrabenazine;Therapeutic;Transmembrane Transport;vacuolar H+-ATPase;Variant;Vesicle;vesicle transport;vesicular monoamine transporter 2;Visualization;Work

PROJECT_TITLE: Deciphering the Molecular Mechanisms of Neurotransmitter Transport

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: AG

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Heart Disease;Physical Activity;Physical Rehabilitation;Rehabilitation

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE  Hospitalization and treatment for cardiovascular disease is one of the main contributors to disability in older adults. Moderate intensity continuous aerobic and resistance training have been the cornerstone of cardiac rehabilitation (CR) for decades to remediate hospital-acquired functional deficits, but some groups receive less or minimal functional benefit from this training. The proposed studies seek to optimize recovery of aerobic fitness and physical function among older cardiac patients using a novel high intensity training regimen with the long-term goal of reducing subsequent disability and improving clinical outcomes.

PI_NAMEs: KHADANGA, SHERRIE  (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Acquired disability;Activities of Daily Living;Address;Adult women;Aerobic Exercise;Age;age related;Aging;Alternative Therapies;Atrophic;Attention;Cardiac;Cardiac rehabilitation;Cardiovascular Diseases;Clinical;clinical practice;Data;design;disability;Disabling;Disease;Effectiveness;efficacy evaluation;efficacy testing;Eligibility Determination;Enrollment;Event;Exercise;exercise intensity;exercise intervention;exercise prescription;exercise program;exercise rehabilitation;exercise training;Foundations;functional disability;Functional disorder;functional gain;functional improvement;Gait speed;Goals;Guidelines;Hospitalization;Hospitals;improved;individual patient;innovation;Intervention;Knowledge;Measures;Mediating;Mediator;mode of exercise;multimodality;Muscle;Muscle Fibers;Muscle Weakness;novel;older adult;older men;older patient;older women;Organ;Outcome;Oxygen;participant enrollment;patient population;patient response;patient subsets;Patients;Phase;Physical Function;physically handicapped;Physiological;primary outcome;programs;Protocols documentation;Publishing;Randomized, Controlled Trials;Recovery;Recovery of Function;Regimen;Rehabilitation therapy;remediation;resistance exercise;response;Role;sex;Site;Skeletal Muscle;skeletal muscle wasting;standard of care;Structure;System;Testing;Tissues;Training;Training Programs;trial design;uptake;Woman;Work

PROJECT_TITLE: Optimizing Aerobic Fitness and Functional Response to Exercise in Older Adults.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-D (02)]


NIH_SPENDING_CATS: Asthma;Clinical Research;Complementary and Integrative Health;Dietary Supplements;Genetics;Human Genome;Lung;Nutrition;Pediatric;Precision Medicine;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative The disruption of fetal developmental processes is hypothesized to give rise to asthma; therefore, prenatal interventions may help reduce its burden. While emerging evidence suggests that maternal vitamin D supplementation during pregnancy can help prevent asthma in the offspring, the molecular mechanisms of this potential protective effect are far from well-understood. Our aim is to identify the molecular determinants that modulate the effect of maternal vitamin D supplementation on childhood asthma by using statistical and network-based computational methods and multi-omic data from randomized clinical trials, with the long-term goal of enabling the precision prevention of childhood asthma.

PI_NAMEs: HALU, ARDA  (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: 25-hydroxyvitamin D;Address;antenatal;Asthma;ATAC-seq;Bayesian Network;Binding Proteins;Biology;Biometry;burden of illness;Cells;Child;Childhood;Childhood Asthma;ChIP-seq;Chronic Disease;Clinical Trials;cohort;Complex;Computational Biology;Computing Methodologies;Conduct Clinical Trials;Data;Developmental Process;DNA Methylation;Dose;Environmental Epidemiology;epigenetic marker;Epigenetic Process;epigenetic regulation;epigenome-wide association studies;epigenomics;Etiology;fetal;Fetal Development;GC gene;gene repression;Genes;Genetic;Genetic Polymorphism;genome wide association study;Genomics;Genotype;Goals;health disparity;Healthcare;Heterogeneity;histone modification;Immune;immunoregulation;Individual;Individual Differences;individualized prevention;innovation;Intake;inter-individual variation;Joints;Ligands;Link;Measures;Mediating;Mediation;Medicine;Meta-Analysis;Metabolism;Methods;Methylation;Microsomes;Mixed Function Oxygenases;Modality;Modeling;Modification;Molecular;Mothers;Multiomic Data;multiple omics;Network-based;Observational Study;offspring;Outcome;Participant;Pathway interactions;Pharmacogenomics;Phenotype;Population;Positioning Attribute;Pregnancy;prenatal intervention;prevent;Prevention;Process;Prospective Studies;protective effect;Quantitative Trait Loci;randomized, clinical trials;Research;Resources;response;Risk;risk prediction;Role;Savings;Serum;Signal Transduction;Statistical Methods;study population;System;Systems Biology;Testing;Time;transcriptomics;translational potential;Umbilical Cord Blood;Vitamin D;Vitamin D supplementation;Vitamin D-Binding Protein;Vitamin D3 Receptor;Wheezing

PROJECT_TITLE: Using statistical network methods to elucidate the multi-omic modulators of the effect of maternal vitamin D levels on childhood asthma

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Glutamate excitotoxicity contributes to the pathogenesis of many different psychiatric disorders and is the primary mechanism for neuronal injury in neurological diseases. Currently, there is no medicine that can suppress glutamate excitotoxicity without inhibiting cognitive functions. Success of this application will open up a new avenue for the development of therapeutic long-lasting autoantibodies that specifically suppress glutamate excitotoxicity and enhance cognitive functions in many neurological diseases and psychiatric disorders including TBI, PTSD, and schizophrenia.

PI_NAMEs: RISBROUGH, VICTORIA B;ZHOU, XIANJIN  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Active Immunization;Address;Antibodies;associated symptom;Autoantibodies;Back;Behavior;Binding;Blood;Blood - brain barrier anatomy;Blood Banks;Blood specimen;blood-brain barrier crossing;Brain;Chronic;Cognition;Cognitive;cognitive enhancement;cognitive function;combat;comparison control;Data;Detection;Development;Diameter;Electron Microscopy;Encephalitis;Epilepsy;Epitopes;excitotoxicity;Exhibits;Glutamates;Human;IgG autoantibodies;Immunoassay;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Impairment;Legal patent;Letters;Locomotion;marine;Marines;Mediating;Medicine;Memory;Memory impairment;Mental Depression;Mental disorders;Methods;monomer;Mus;Mutant Strains Mice;Nervous System Disorder;Neurologic Symptoms;Neuronal Injury;neuronal survival;Neurons;neuroprotection;neurotransmission;NMDA receptor A1;novel;P2 peptide;Pathogenesis;Patients;Performance;Phenotype;Plasma;Population;Post-Traumatic Stress Disorders;psychiatric symptom;Psychoses;Reaction Time;Reporting;resilience;Schizophrenia;Short-Term Memory;Stroke;success;Symptoms;Synapses;Synaptic Cleft;Testing;therapeutic development;Time;Traumatic Brain Injury;Validation;Width

PROJECT_TITLE: Effects of Different Isotypes of Anti-NMDAR1 Autoantibodies on Cognitive Function and Neuroprotection

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Immunization;Immunotherapy;Nanotechnology;Vaccine Related;Women's Health Research

ORG_DEPT: PHARMACOLOGY

PHR: NARRATIVE This grant proposal is to develop a novel cancer vaccine, called VAM-B/CD4, that promotes B/CD4 T cell crosstalk to achieve long-term durable anticancer efficacy. This novel vaccine design strategy will have significantly positive impact to achieve long-term durable anticancer efficacy in many types of cancers.

PI_NAMEs: GAO, WEI ;SUN, DUXIN  (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: anti-cancer;anti-PD-1;Antibody Formation;Antigen Mimicry;Antigen Presentation;Antigen-Presenting Cells;Antigens;Applications Grants;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocyte Epitopes;B-Lymphocytes;Binding;Cancer Model;cancer type;Cancer Vaccines;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Clinical Research;Colon Carcinoma;crosslink;Data;Dendritic Cells;density;design;Disease remission;Epitopes;ERBB2 gene;Immunity;Immunologic Memory;Immunotherapy;In complete remission;innovation;long term memory;lymph nodes;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Melanoma;Memory;Memory B-Lymphocyte;mimicry;Mus;Nanodelivery;nanovaccine;neoantigen vaccine;neoantigens;novel;novel vaccines;Peptides;preclinical study;Role;Structure;System;T cell response;T memory cell;T-Lymphocyte;T-Lymphocyte Epitopes;Therapeutic;therapeutic vaccine;trafficking;tumor;uptake;Vaccine Design;Vaccines;Viral;Viral Antigens

PROJECT_TITLE: Therapeutic Cancer NanoVaccine Promotes B/CD 4 T Cell Crosstalk for Durable Anticancer Efficacy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (81)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Primary Immunodeficiencies;Psychosis;Rare Diseases;Serious Mental Illness;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Neuropsychiatric manifestations are common in 22q11.2 deletion syndrome (22qDS), affecting brain development and functioning with marked heterogeneity. We propose to examine developmental trajectories in a cohort of adolescents and young adults and their parents, integrating prospective dimensional and categorical phenotyping of psychopathology, neurobehavioral, environmental exposures, and medical burden. This work will identify convergent risk mechanisms for developmental neuropsychiatric disorders that have relevance to the broader population.

PI_NAMEs: GUR, RAQUEL E (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: 22q;22q11.2;Acceleration;Address;Adolescence;Adolescent and Young Adult;Affect;Age;Algorithms;Anxiety;Architecture;Attention deficit hyperactivity disorder;Authorization documentation;autism spectrum disorder;Behavior;Behavioral;Brain;brain behavior;case control;Cell Line;Clinical;Clinical Data;Cognitive deficits;cohort;Collaborations;comorbidity;computerized;critical period;Data;data sharing;Development;Developmental Course;Developmental Delay Disorders;DiGeorge Syndrome;Dimensions;Disease;DNA;Early identification;Electronic Health Record;emerging adult;emerging adulthood;Environmental Exposure;Environmental Impact;Environmental Risk Factor;Evaluation;executive function;externalizing behavior;Family;Female;functional outcomes;General Population;Genes;Genetic;Genetic Risk;genetic variant;Genetic Variation;Genome;genome resource;Genomics;Goals;Grain;Heterogeneity;high risk;Home;Individual;insight;Institution;Intellectual functioning disability;intergenerational;International;Investigation;Knowledge;Laboratories;Language;Language Development;Lead;life span;Link;Literature;longitudinal design;male;Measures;Medical;Mental Health;Methods;model building;multimodality;National Institute of Mental Health;Nature;Neighborhoods;neurobehavioral;Neurocognition;Neurocognitive;Neurocognitive Deficit;neuropsychiatric disorder;neuropsychiatry;novel;offspring;Outcome;Parents;Pediatric Hospitals;Performance;Persons;Pharmaceutical Preparations;phenome;phenomics;Phenotype;phenotypic data;Philadelphia;Play;polygenic risk score;Population;Positioning Attribute;precision medicine;prenatal;proband;prospective;Psychiatry;Psychopathology;Psychoses;psychotic symptoms;Public Domains;Recontacts;Recording of previous events;recruit;Research;research clinical testing;resilience;resilience factor;Resources;response;Risk;Risk Factors;risk prediction model;Role;Sampling;severe mental illness;Short-Term Memory;Stress;Syndrome;Testing;Variant;Work;young adult;Youth

PROJECT_TITLE: 1/2: Neurodevelopmental Trajectories in 22q11.2 Deletion Syndrome in Adolescence and Young Adulthood

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-D (65)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative The ultimate goal is to discover kinase inhibitors that could be developed as an oral multi parasite effective therapeutic against cryptosporidiosis and giardiasis diarrhea with potential usefulness in other intestinal parasitic diseases. We have demonstrated that kinase inhibitors from two chemotypes have selective inhibition of the parasites with one shown to be therapeutically effective in mouse infection models of Giardia lamblia and Cryptosporidium parvum. The common anatomical infection site of these etiological agents and symptomatic presentations should aid in finding a dual use drug because of similar pharmacokinetic (PK) and pharmacodynamic (PD) requirements for a syndromic treatment of the diseases.

PI_NAMEs: FAN, ERKANG ;OJO, KAYODE K (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: 3-Dimensional;Affect;Ames Assay;Aminopyridines;analog;Anatomy;Animals;Attention;bioimaging;Biological Assay;candidate selection;Cell Line;Cells;cellular microvillus;Chemicals;Child;Chronic diarrhea;Clinical;Clinical Trials;clinically relevant;Collection;Computer software;Country;Cryptosporidiosis;Cryptosporidium;Cryptosporidium parvum;Cytochrome P450;cytotoxicity;Data;Derivation procedure;design;Development;Diagnosis;Diarrhea;Disease;Dose;drug discovery;Drug Kinetics;Drug usage;effective therapy;efficacy study;efficacy testing;Enzymes;Epithelial Cells;Etiology;experimental study;follow-up;Funding;Giardia;Giardia lamblia;Giardiasis;global health;Goals;Growth;Hand;Health Benefit;high throughput screening;Human;Immunocompromised Host;improved;In Vitro;in vitro Assay;in vitro testing;in vivo;Infection;Intestines;Ion Channel;Isoenzymes;kinase inhibitor;Lead;lead optimization;Libraries;Link;Liquid substance;Malnutrition;Mammalian Cell;Measurement;Metabolism;meter;Metronidazole;Micronucleus Tests;Microsomes;Modeling;mouse model;Mus;novel;Oral;Parasites;Parasitic infection;Parasitic Intestinal Diseases;patch clamp;pathogen;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phase;Phenotype;Phosphotransferases;Population;pre-clinical;preclinical development;programs;Promega;Property;protein kinase inhibitor;Proteomics;Public Health;Pyrimidine;Rattus;receptor;Research Contracts;Research Proposals;research study;Resistance;resistance frequency;resistant strain;Resources;Safety;safety testing;scaffold;scale up;screening;Series;Site;Small Intestines;Solubility;Stomach;Structure-Activity Relationship;System;Testing;Therapeutic;therapeutic evaluation;Therapeutic Uses;therapeutically effective;Toxic effect;Toxicology;Work

PROJECT_TITLE: Development of dual effective kinase inhibitors as syndromic treatment of Giardiasis and Cryptosporidiosis

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Cancer immunotherapy resistance in squamous cell carcinomas is found to be orchestrated by a special group of tumor-initiating cells. This project aims to uncover novel mechanisms activated by Sox2 to reprogram the immune suppressive microenvironment and intrinsic resistance of tumor- initiating cells. The ultimate goal of this project is to leverage the findings from this study for more effective immunotherapies that can overcome cancer recurrence.

PI_NAMEs: MIAO, YUXUAN PHOENIX (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Adult;Antigen Presentation;Automobile Driving;cancer cell;cancer immunotherapy;cancer recurrence;Cancer Relapse;cancer therapy;Cell Survival;Cells;Clinical;Complex;Development;Endowment;enhancing factor;exhaustion;experience;experimental study;Gene Delivery;gene network;Gene Silencing;Genes;genetic manipulation;Genetic Transcription;Genetically Engineered Mouse;Goals;Head and Neck Squamous Cell Carcinoma;Head and neck structure;humanized mouse;Immune;immune checkpoint blockade;Immune Evasion;immune resistance;Immunity;Immunotherapy;improved;in utero;Malignant Neoplasms;Mediating;Microinjections;Modeling;Molecular;Molecular Profiling;Mus;Myeloid-derived suppressor cells;Nature;neoplastic cell;novel;novel strategies;Outcome;Patients;Pilot Projects;Population;Positioning Attribute;prevent;Process;programs;recruit;Recurrence;Refractory;Relapse;Research;Resistance;resistance mechanism;response;Role;Shapes;Site;Skin;Solid Neoplasm;Squamous cell carcinoma;stemness;success;T-Lymphocyte;Techniques;Technology;Testing;Therapeutic;tissue stem cells;Tissues;transcription factor;Transforming Growth Factor beta;tumor;Tumor Escape;Tumor Immunity;tumor initiation;ultrasound

PROJECT_TITLE: Dissecting the Sox2-orchestrated transcriptional network that governs immune resistance in tumor initiating cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Q (80)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: NARRATIVE This study addresses a high-priority public health need by using technology to examine an intervention to help family care partners address behavioral symptoms for individuals with frontotemporal dementia. The proposed study tests the preliminary efficacy and analyzes the mechanism of action of an intervention using the well- known “ABC” problem solving approach to behavior change, with results informing long-term health and burden in care-givers. Upon completion we will have reliable data to sufficiently understand the underlying principles of STELLA-FTD, in order to test them in an NIH Stage 2 study, with the ultimate goal of making STELLA-FTD scalable for implementation in the community.

PI_NAMEs: LINDAUER, ALLISON  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: acceptability and feasibility;Address;Advanced Development;Age;Agitation;Alzheimer's disease related dementia;Attention;Behavior;behavior change;Behavior Therapy;Behavioral;Behavioral Symptoms;caregiving;Caring;Clinical Trials;Communities;Control Groups;Data;Data Analyses;Dementia;dementia care;design;Diagnosis;Discipline of Nursing;Disease;Disinhibition;Distress;Dose;Education;Educational Curriculum;Family;Family member;Foundations;frontotemporal degeneration;Frontotemporal Dementia;Future;Goals;Health;Individual;Instruction;Intervention;Language;Learning;Literature;Lobe;Measures;Mediating;Memory;Mental Health;misfolded protein;neuropathology;Outcome;Outcome Measure;Participant;peer;peer support;Persons;physical conditioning;primary outcome;Problem behavior;Problem Solving;Process Assessment;Protocols documentation;psychoeducation;public health priorities;Randomized;Rehabilitation therapy;Research;Science;Self Efficacy;Standardization;Symptoms;Techniques;Technology;Testing;theories;therapy development;Training;trial comparing;United States National Institutes of Health;Videoconferencing;Work

PROJECT_TITLE: STELLA-FTD: Examination of a Behavior Change Intervention for FTD Family Care Partners

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-S (O1)]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Fibromyalgia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pain Research;Rehabilitation;Sleep Research;Social Determinants of Health

PHR: NARRATIVE Novel adjunctive treatments for fibromyalgia (FM) that have optimal treatment effects, minimal side effects, and are easy to implement and readily accessible for all are needed. Morning bright light treatment is an accessible and scalable non-pharmacological treatment for FM, and can lead to significant improvements in function and pain. This large clinical trial will determine the active elements of morning bright light treatment for FM, the impact of social determinants of health on symptom burden and treatment, and explore mechanisms of action to assist in developing morning bright light treatment as a treatment for chronic pain.

PI_NAMEs: BURGESS, HELEN JULIA (contact);HASSETT, AFTON L

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Adherence;Adverse effects;Affect;affective disturbance;Aftercare;Age;American;Area;Chronic;chronic pain;chronic pain management;chronic widespread pain;circadian;Clinical;Clinical Trials;Cognitive Therapy;Communities;depressive symptoms;deprivation;Development;Devices;disability;Education;Elements;Employment;Enrollment;Ethnic Origin;Exercise;Fatigue;Fibromyalgia;fibromyalgia pain;follow-up;functional improvement;Guidelines;Home;Hour;Impaired cognition;improved;improved outcome;improvement on sleep;Income;indexing;Individual;Insurance;Light;Mediating;Medical;Mental Depression;Meta-Analysis;Nonpharmacologic Therapy;novel;optimal treatments;Outcome;Pain;Pain intensity;pain outcome;Participant;Patient Outcomes Assessments;perceived discrimination;Persons;Pharmacological Treatment;Phototherapy;Physical therapy;primary outcome;Productivity;Quality of life;Race;Randomized;Research;Resources;Risk;Sampling;Self Administration;sex;side effect;Sleep;Sleep disturbances;sleep quality;social health determinants;social influence;Social support;social vulnerability;sociocultural determinant;sociodemographic group;sociodemographics;Symptom Burden;symptom treatment;Symptoms;Testing;treatment adherence;treatment as usual;treatment effect;treatment group;treatment response;Underserved Population;virtual assessment;wearable device

PROJECT_TITLE: At Home Morning Bright Light Treatment For Chronic Nociplastic Pain Amongst Sociodemographically Diverse Individuals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-X (02)]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Substance Misuse;Suicide

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Project Narrative The proposed research is relevant to public health because understanding how social and environmental factors influence the substance use, mental health, and suicidality of non-prescriber/non-executive healthcare workers can inform more practical and effective prevention and intervention efforts that address drivers of health that exist beyond the individual level for an at-risk and growing population. This proposal aligns with NIDA’s strategic plan for 2022 – 2026, which specifically calls to enhance the knowledge of the contextual landscape of drug use and to determine individual and population-level risk and protective factors for drug use and addiction across the lifespan. Additionally, this proposal is relevant to NIH’s mission to “foster fundamental creative discoveries, innovative research strategies, and their applications as a basis for ultimately protecting and improving health.”

PI_NAMEs: HOMISH, GREGORY G.;HOOPSICK, RACHEL  (contact)

PROGRAM_OFFICER_NAME: COLLIER KIDEMU, KEVA WONTORIA

PROJECT_TERMS: Address;Administrator;Adult;Affect;Alcohol consumption;Ambulatory Care Facilities;Anger;Anxiety;Attention;Behavior;Behavioral;Belief;burnout;community-level factor;Computer Assisted;COVID-19;COVID-19 pandemic;Creativeness;Data;design;Development;dietary;Discipline of Nursing;disease transmission;Drug Addiction;Drug usage;effective intervention;Environment;Environmental Risk Factor;Event;expectation;experience;Feeling suicidal;follow-up;Fostering;Functional disorder;hazardous drinking;Health;Health Personnel;Healthcare;Healthcare Systems;Home Care Services;Hospitals;Hour;illicit drug use;Illicit Drugs;improved;Individual;innovation;Intervention;Interview;Job Satisfaction;Knowledge;life span;Life Stress;Literature;longitudinal analysis;Low income;male health;marijuana use;Medical Occupation;Medical Waste;Mental Depression;Mental Health;Methods;Military Personnel;military service;Mission;misuse of prescription only drugs;model building;Modeling;Moral injury;Morals;National Institute of Drug Abuse;Occupational;occupational hazard;Occupations;Outcome;pandemic disease;Patients;peer networks;Personal Satisfaction;Persons;Physicians;Policies;Population;post-traumatic stress;Post-Traumatic Stress Disorders;Predisposition;prevent;Prevention;programs;protective factors;psychologic;psychosocial;Public Health;Publishing;Quality of life;Recording of previous events;recruit;Research;Residential Facilities;resilience;resilience factor;Resources;Risk;Risk Factors;Role;Sampling;Schedule;service member;sleep quality;social;social factors;social health determinants;social media;Social support;Societal Factors;Socioeconomic Status;Strategic Planning;Stress;stressor;substance misuse;substance use;Substance Use Disorder;suicidal;suicidal behavior;Surgeon;symptomatology;Theoretical model;Time;Tobacco use;Trauma;United States;United States National Institutes of Health;Wages;Work;worker safety;Workload;Workplace

PROJECT_TITLE: A Longitudinal Examination of the Social and Environmental Influences on Substance Use among Non-Prescriber/Non-Executive Healthcare Workers in the United States


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Nutrition;Obesity

PHR: NARRATIVE The cerebellum, a brain region traditionally associated with sensorimotor control, has been shown to be involved in reward-related satiety in an appetitive state-specific manner in animal models and in observational data in humans. However, validation of this circuit using an integrated neuromodulation and neuroimaging approach has not been examined, and data on causal mechanisms in humans are lacking. This project will provide mechanistic insight into the role of the cerebellar-ventral striatal circuit as a critical regulator of reward-related satiety and food intake in humans, thereby informing the potential neurobiological pathways to target in the development of obesity therapeutics.

PI_NAMEs: BRADY, ROSCOE O.;HALKO, MARK A;HOLSEN, LAURA MCGRATH (contact)

PROGRAM_OFFICER_NAME: WOO, THERESA TESLOVICH

PROJECT_TERMS: Acute;addiction;Adult;advanced system;Affect;animal data;Animal Feed;Animal Model;Animals;Appetitive Behavior;Attention;Attenuated;attenuation;Behavior;behavior measurement;Behavioral;behavioral response;Biological;blood oxygen level dependent;Body mass index;Brain;brain behavior;brain circuitry;Brain region;Cerebellar Cortex;Cerebellum;Clinical Trials;Complex;computerized;Corpus striatum structure;craving;Cues;Data;design;Desire for food;Development;Double-Blind Method;Eating;effective therapy;experimental study;Fasting;Feeding behaviors;Food;food consumption;food craving;Food deprivation (experimental);Functional Magnetic Resonance Imaging;Future;Goals;healthy weight;Human;Human Characteristics;human data;Hypothalamic structure;Individual;innovation;insight;Intake;Intervention;Link;Measures;Mental Depression;Morbidity - disease rate;mortality;Mus;network dysfunction;neural;neural circuit;neurobehavioral;Neurobiology;neuroimaging;neuropsychiatry;neuroregulation;Neurosciences;novel;Obesity;obesity development;obesity risk;obesity treatment;Participant;Pathway interactions;patient population;Population;Prader-Willi Syndrome;pre-clinical;Prevalence;Protocols documentation;Public Health;Randomized;reduce symptoms;Regulation;response;Rewards;Role;Satiation;Satiety Response;Severities;Source;Specificity;success;Symptoms;System;Task Performances;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;tool;Transcranial magnetic stimulation;Translating;translational approach;Translations;trend;Validation;Ventral Striatum

PROJECT_TITLE: Validation of a novel cerebellar-striatal satiety circuit in human

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: BLACKSBURG

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: PROJECT NARRATIVE Low level lead (Pb) exposure via drinking water is an everyday problem of high prevalence and is unavoidable for many individuals worldwide. Little is known about how Pb alters the composition of gut microbiota and the secondary impacts on brain development in children, which are more vulnerable than adults. Here, we propose to dissect out the causal role of Pb-induced gut dysbiosis on the central and enteric nervous systems.

PI_NAMEs: MORTON, PAUL DAVID (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: absorption;Acceleration;Adult;Affect;American;Animal Model;Animals;Attention;autism spectrum disorder;bacterial resistance;Binding;Biological Assay;Blood;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;Brain Diseases;Calcium;Calcium-Binding Proteins;cell type;Cells;Central Nervous System;Chemicals;Child;Child Nutrition;Clinical;Colitis;Communication;Confocal Microscopy;Congresses;Development;developmental disease;Disease;Dose;drinking water;Electron Microscopy;Enteral;Enteric Nervous System;Environmental Exposure;Evaluation;Exocytosis;experience;experimental study;Exposure to;Family suidae;Feces;Funding;Gastrointestinal tract structure;General Population;Genes;Germ-Free;Growth;gut dysbiosis;gut microbiome;gut microbiota;gut-brain axis;Heavy Metals;High Prevalence;Histology;Human;Image;Imaging Techniques;Immune system;impaired brain development;Impaired cognition;improved;In Vitro;in vivo;Individual;Infant;Infrastructure;Ingestion;insight;Interneurons;Intestinal permeability;Intestines;Knowledge;Lead;lead contamination;lead exposure;Lead levels;Link;loss of function mutation;Magnetic Resonance Imaging;Michigan;microbial;microbiome;microbiome alteration;microbiota;microorganism;model organism;Modeling;multiple omics;Mus;Neocortex;nervous system development;Nervous System Disorder;neurodevelopment;Neurodevelopmental Disorder;Neurological outcome;Neurons;Neurosecretory Systems;neurotoxic;novel;novel strategies;Nutritional Study;Oligodendroglia;Oral;Organ;Parkinson Disease;Physiology;Play;Policies;porcine model;pre-clinical;Pre-Clinical Model;Predisposition;Proteins;Reporting;Rodent;Role;Series;Services;Sex Differences;Signal Transduction;Source;Stream;System;targeted treatment;Techniques;Teratogens;Testing;Therapeutic Intervention;Training;Water;Water consumption;Water Supply;white matter;Work;Zebrafish

PROJECT_TITLE: Evaluation of Pb-induced perturbations in the central and enteric nervous system

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Companion animals, such as horses and dogs, display highly variable mammary cancer incidence and are sentinels for human health as they share comparable habitats and are exposed to similar environmental risk factors. We will use our newly established mammary xenograft mouse model to identify responses to 7,12- dimethylbenz[a]-anthracene (DMBA), a synthetic carcinogen belonging to the polycyclic aromatic hydrocarbon (PAH) environmental pollutant family, in these sentinel mammals that are either resistant (horse) or susceptible (dog) to mammary cancer. The knowledge gained from these studies will increase our understanding on the effects of environmental pollutants on mammary gland health and will help define important regulatory mechanisms that can ultimately result in the identification of biomarkers of exposure and breast cancer risk.

PI_NAMEs: HARMAN, REBECCA M (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Address;Air Pollution;Animals;Anthracenes;Apoptosis;Apoptotic;Architecture;Aromatic Polycyclic Hydrocarbons;Attenuated;Automobile Driving;biomarker identification;Breast Cancer Risk Factor;cancer type;Canis familiaris;Carcinogens;cell injury;Cells;Characteristics;companion animal;comparative;Complementary DNA;cost;Data;Derivation procedure;Development;dimethylbenzanthracene;DNA Damage;Domestic Animals;Dose;Environmental Carcinogens;Environmental Pollutants;Environmental Risk Factor;Equus caballus;Euthanasia;Evaluation;exposed human population;Exposure to;Family;Fatty acid glycerol esters;Gene Expression;Genes;Genetic;Genomics;Gland;Goals;Habitats;Health;Histologic;Hormone Responsive;Human;Image;Immunodeficient Mouse;Immunohistochemistry;improved;In Vitro;in vivo;Incidence;innovation;insight;Isogenic transplantation;knock-down;Knowledge;Label;Link;Malignant - descriptor;Malignant Neoplasms;Mammals;mammary;Mammary gland;Mammary Neoplasms;Mediating;Messenger RNA;Methods;Mitotic;Modeling;mouse model;Mus;Mutation;Necrosis;neoplastic;Neoplastic Cell Transformation;NF-kappa B;novel;Outcome;Pathway interactions;Permeability;Pesticides;Populations at Risk;Predisposition;Proliferating;Public Health;public health research;Publishing;repaired;Research;Resistance;resistance mechanism;response;Risk;Rodent;Sentinel;Slide;stem;Testing;Tissue Transplantation;Tissues;tool;Transcript;transcriptomics;Transplantation;Treatment Protocols;tumor;tumorigenesis;tumorigenic;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Environmental mammary carcinogen evaluation in a xenotransplantation mouse model

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]