ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Recovery Support Services;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Targeting the intersection of justice and community-based care had substantial potential for addressing the opioid crisis. The unprecedented public health opioid crisis among justice-involved individuals necessitates rigorous and well-designed studies to inform interventions and implementation frameworks that produce sustained public health impact. We propose a type 1 hybrid implementation-effectiveness trial targeting the community supervision setting using 7 performance sites in Rhode Island, North Carolina, and Pennsylvania to test probationer/parolee client engagement in MOUD.

PI_NAMEs: BRINKLEY-RUBINSTEIN, LAUREN ;MARTIN, ROSEMARIE A (contact);ROHSENOW, DAMARIS J.

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Address;Adoption;Caring;Client;Communities;community based care;Community Services;community setting;correctional system;cost;Country;Drops;effectiveness outcome;effectiveness/implementation design;effectiveness/implementation trial;Eligibility Determination;evidence base;Exploration, Preparation, Implementation, and Sustainment;FDA approved;follow-up;Foundations;Geography;high risk;implementation evaluation;implementation framework;implementation intervention;implementation outcomes;implementation science;implementation strategy;Imprisonment;improved;Individual;Intervention;Jail;Justice;medication for opioid use disorder;North Carolina;Opioid;opioid epidemic;opioid overdose;opioid use;Overdose;overdose death;parole;parolee;peer recovery;peer support;Penetration;Pennsylvania;performance site;Persons;Pharmaceutical Preparations;Prisons;probation;probationer;Program Acceptability;programs;Public Health;Randomized;recidivism;recovery services;Recovery Support;Relapse;Research;Research Design;Rhode Island;satisfaction;service delivery;service providers;Services;Site;Specialist;substance abuse treatment;Substance Use Disorder;Supervision;sustainability framework;System;Testing;Treatment outcome;Work

PROJECT_TITLE: Using Implementation Interventions and Peer Recovery Support to Improve Opioid Treatment Outcomes in Community Supervision


ADMINISTERING_IC: HS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: TUCSON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Necrotizing enterocolitis (NEC) disproportionately affects people of color and is a significant cause of emergency surgery and death among fragile infants. This project, using a telehealth-delivered mentoring intervention called "NeoECHO," aims to provide evidence of its effectiveness in adopting NEC prevention measures and gather information on structural differences in neonatal intensive care units (NICUs) to ultimately eliminate NEC disparities.

PI_NAMEs: GEPHART, SHEILA MARIA (contact)

PROGRAM_OFFICER_NAME: SAGATOV, ROBYN

PROJECT_TITLE: Reducing Necrotizing Enterocolitis Disparities with a Neonatal Project ECHO

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: SEATTLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative RAS is a central component of many intracellular signaling networks in eukaryotes. Despite the role of mis- regulated RAS in numerous cancers, many fundamental aspects of RAS-mediated signaling are still poorly understood. Here, we will quantitatively characterize the dynamics of RAS-driven signaling in different cellular environments and explore the effects of signaling crosstalk.

PI_NAMEs: MALY, DUSTIN J (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Address;Affect;Behavior;Behavior Control;Binding;Biology;Cancer cell line;Cell Physiology;Cells;chemical genetics;Chemicals;Clinical;Complex;Development;dimer;Dimerization;Dose;Environment;Enzymes;Eukaryota;Feedback;Generations;genetic analysis;GTP Binding;Guanosine Triphosphate Phosphohydrolases;inhibitor;inhibitor therapy;insight;interest;Investigation;kinase inhibitor;KRAS oncogenesis;Location;Malignant Neoplasms;Mammalian Cell;Mediating;MEKs;Methods;migration;Molecular;mutant;novel;Oncogenic;Output;Pathway interactions;Permeability;phosphoproteomics;Phosphotransferases;Play;Process;Proliferating;Protein Isoforms;Proteins;Proteomics;RAS genes;RAS inhibition;Ras Inhibitor;recruit;Resistance;response;Role;Signal Pathway;Signal Transduction;small molecule;spatiotemporal;System;T-Cell Development;Technology;technology platform;Time;tool;trafficking;transcriptomics;Work

PROJECT_TITLE: Chemical Genetic Analysis of RAS Signaling

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Social Determinants of Health

ORG_CITY: MOSCOW

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PI_NAMEs: BOHACH, CAROLYN HOVDE (contact)

PROGRAM_OFFICER_NAME: ARORA, KRISHAN

PROJECT_TERMS: Address;Advisory Committees;Articulation;Bioinformatics;Biomedical Research;built environment;Businesses;career;Centers of Research Excellence;Charge;Climate;Collaborations;Committee Members;Communication;Communities;community college;conflict resolution;Curiosities;Degree Completion;Degree program;Development;Diverse Workforce;doctoral student;Education;education research;education resources;Educational Curriculum;Educational process of instructing;Eligibility Determination;Ensure;Environment;Evaluation;experience;Face;Faculty;faculty mentor;faculty research;formative assessment;Fostering;Funding;Goals;Grant;Health;higher education;Idaho;improved;Individual;Industrialization;Industry;Influentials;Infrastructure;innovation;Institution;interdisciplinary collaboration;interest;International;Internships;Knowledge;Leadership;Link;Medical Education;Medical Students;member;Mentors;Modification;Monitor;Montana;multidisciplinary;New Mexico;Outcome;Persons;Positioning Attribute;Postdoctoral Fellow;Process;Program Research Project Grants;programs;Qualifying;recruit;Rejuvenation;Research;Research Activity;research facility;Research Infrastructure;Research Personnel;Research Support;Resources;Rural;Science;science education;Science, Technology, Engineering and Mathematics Education;Scientist;Series;Signal Transduction;skills;Structure;student training;Students;success;symposium;System;Talents;Teacher Professional Development;Training;Training and Education;undergraduate research;undergraduate student;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities;Vision

PROJECT_TITLE: Idaho INBRE Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research

PI_NAMEs: CORNELL, KENNETH A (contact)

PROJECT_TERMS: Address;Area;Assessment tool;Binding;Bioinformatics;bioinformatics resource;bioinformatics tool;Biomedical Research;Biometry;career development;Centers of Research Excellence;Collaborations;college;community college;Computational Biology;computing resources;Core Facility;cyber infrastructure;Data;data management;Data Storage and Retrieval;Dedications;Degree program;Development;DNA sequencing;Doctor of Philosophy;Education;education resources;Educational Curriculum;Educational process of instructing;Educational workshop;Environment;equipment acquisition;experience;Faculty;faculty mentor;Flow Cytometry;Funding;genome resource;graduate student;Grant;Idaho;Image;Image Cytometry;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;knowledge network;Laboratories;laboratory experiment;Learning;lectures;Life Cycle Stages;Location;member;Mentors;metabolomics;Molecular;Montana;New Mexico;online resource;operation;optical imaging;Pilot Projects;Positioning Attribute;programs;Proteins;Proteomics;Qualifying;repository;Research;Research Personnel;Research Project Grants;Resources;Role;Running;Science;Secure;Services;Signal Transduction;Site;skills;Specialized Center;Stream;student training;Students;Technology;Time;tool;Training;Training and Education;transcriptome sequencing;undergraduate research experience;undergraduate student;United States Department of Agriculture;United States National Institutes of Health;Universities;web site

PROJECT_TITLE: Idaho INBRE Bioinformatics Core


PI_NAMEs: MINNICH, SCOTT A (contact)

PROJECT_TERMS: Abbreviations;Address;Advisory Committees;Appointment;Area;Award;Biomedical Research;Budgets;career;career development;Committee Members;Communities;community college;community engagement;Core Facility;Development;Doctor of Philosophy;Educational process of instructing;Eligibility Determination;Ensure;Environment;Equilibrium;Evaluation;experience;Faculty;faculty mentor;faculty research;Feedback;flexibility;Foundations;Funding;Funding Opportunities;Goals;Grant;health disparity;high standard;Idaho;Infrastructure;innovation;insight;Institution;Interdisciplinary Study;interest;Investments;Lead;Measures;Medical Education;medical schools;Mentors;Montana;multidisciplinary;National Institute of General Medical Sciences;New Mexico;novel;Outcome;Participant;Pathogenesis;Pilot Projects;Policies;Population;Process;Productivity;Program Research Project Grants;programs;Publications;Qualifying;Ramp;Recommendation;Recording of previous events;recruit;Research;Research Personnel;Resource Sharing;Resources;Review Committee;Science;Scientist;Secure;Selection Criteria;Signal Transduction;skills training;Students;success;Talents;Training;undergraduate student;Underrepresented Students;underserved students;United States National Institutes of Health;Universities;Washington;Work

PROJECT_TITLE: Developmental Research Project Program


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: FAIRBANKS

ORG_NAME: UNIVERSITY OF ALASKA FAIRBANKS

ORG_STATE: AK

PI_NAMEs: BARNES, BRIAN M (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Address;Administrator;Advisory Committees;Advocate;Alaska;Alaska Native;Alaska Native population;Alaskan;Animals;Award;Behavior;behavioral health;Behavioral Research;Benchmarking;Biomedical Research;career;Clinical Research;Collaborations;Communication;Communities;conflict resolution;Databases;Decision Making;design;Development;Doctor of Philosophy;Education;effectiveness evaluation;Eligibility Determination;Ensure;Environmental Science;Evaluation;experience;Faculty;Failure;Family;Feedback;Fostering;Foundations;Goals;Grant;Health;health disparity;health organization;Health system;Human;Individual;Infrastructure;Institution;Interdisciplinary Study;Investments;Lead;Leadership;Life Cycle Stages;Logistics;meeting reports;meetings;member;Modification;Newsletter;Organizational Productivity;Outcome;outreach;patient engagement;Personal Satisfaction;Process;programs;Recommendation;recruit;Reporting;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resource Sharing;social media;Students;success;systems research;Training;Translational Research;tribal health;United States National Institutes of Health;Universities;Wages;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research

PI_NAMEs: BURKHEAD, JASON L (contact)

PROJECT_TERMS: Address;Alaska;Alaska Native;Alaska Native population;Alaskan;Animals;Award;behavioral health;Bioinformatics;bioinformatics resource;Biomedical Research;Biometry;career;career development;Clinical Research;Collaborations;Communities;Consultations;curriculum development;data acquisition;Data Analyses;Development;distributed model;Education;Educational Curriculum;Educational workshop;Enhancement Technology;Environment;Environmental Science;Equipment;experience;Experimental Designs;Faculty;Family;Foundations;Funding;Genes;genome resource;Goals;Health;health disparity;health organization;High Performance Computing;Human;Individual;Infrastructure;Institution;instrumentation;Interdisciplinary Study;Investments;Leadership;Methodology;Methods;Microbe;Modeling;Modernization;nanopore;next generation sequencing;Personal Satisfaction;Persons;Plants;Postdoctoral Fellow;programs;Proteins;Proteomics;recruit;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Scientist;Services;Sorting;student training;Students;System;Technology;tool;Training;Translational Research;Travel;tribal health;United States National Institutes of Health;Universities

PROJECT_TITLE: Bioinformatics Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: O'BRIEN, KRISTIN  (contact)

PROJECT_TERMS: Achievement;Address;Alaska;Alaska Native;Alaska Native population;Alaskan;Animals;Assistantship;Award;base;Basic Science;behavioral health;Behavioral Research;Biomedical Research;career;Clinical Research;Collaborations;Communities;curriculum development;Development;Education;Educational Curriculum;Educational workshop;Engineering;Environmental Science;experience;Faculty;Family;Fostering;Foundations;frontier;Future;Goals;graduate student;Health;health disparity;health knowledge;health organization;Healthcare;Human;improved;Individual;Infrastructure;Institution;Interdisciplinary Study;interest;Investments;Knowledge;knowledge base;Leadership;learning community;Medical;Personal Satisfaction;programs;recruit;Research;Research Infrastructure;Research Personnel;Research Support;Research Training;Resource Sharing;Rural;Science;student participation;Students;success;Support System;System;Technology;Training;Training in Biomedical and Behavioral Research;Translational Research;Travel;tribal health;undergraduate research experience;undergraduate student;Underserved Population;underserved students;United States National Institutes of Health;Universities

PROJECT_TITLE: Research Experiences Core


PI_NAMEs: SHELBY, JOANNE  (contact)

PROJECT_TERMS: Achievement;Address;Alaska;Alaska Native;Alaska Native population;Alaskan;Animals;Award;Behavioral;behavioral health;Behavioral Research;Biomedical Research;career;career development;Clinical Research;Collaborations;Communication;Communities;Development;Education;Educational process of instructing;Eligibility Determination;Environmental Science;Equipment;experience;Faculty;faculty support;Family;Foundations;Funding;Goals;graduate student;Grant;Health;health disparity;health organization;Human;Incentives;Individual;Infrastructure;Institution;Interdisciplinary Study;International;Investments;Knowledge;Laboratory Technicians;Lead;Leadership;Personal Satisfaction;Pilot Projects;Postdoctoral Fellow;Program Research Project Grants;programs;Publications;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Proposals;Resource Sharing;Resources;Science;Scientist;Students;success;Training;Translational Research;Travel;tribal health;undergraduate student;United States National Institutes of Health;Universities;Wages

PROJECT_TITLE: Sustaining Research Excellence Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Address;Advisory Committees;Agreement;Alaska;Alaska Native;Alaska Native population;Alaskan;Animals;Appointment;Award;Basic Science;behavioral health;Behavioral Research;Biomedical Research;career;career development;Clinical Research;Collaborations;Communities;design;Development;Direct Costs;Education;Educational workshop;Eligibility Determination;Environment;Environmental Science;expectation;experience;Faculty;Family;Foundations;Funding;Goals;Grant;Growth;Health;health disparity;health organization;Human;improved;Incentives;Individual;Infrastructure;Institution;interdisciplinary collaboration;Interdisciplinary Study;Investments;Laboratories;Lead;Leadership;Letters;meetings;multidisciplinary;National Institute of General Medical Sciences;Participant;Personal Satisfaction;Pilot Projects;Principal Investigator;Productivity;Program Research Project Grants;programs;Publishing;Recommendation;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Proposals;Resource Sharing;responsible research conduct;Safety;Science;Site;student training;Students;success;Time;Training;Training Programs;Translational Research;tribal health;undergraduate student;United States National Institutes of Health;Work

PROJECT_TITLE: Developmental Research Pilot Project


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PI_NAMEs: DUNCAN, MELINDA K (contact)

PROJECT_TERMS: Advisory Committees;American Association for the Advancement of Science;Bioinformatics;Biomedical Research;career;Collaborations;Communities;Critiques;Delaware;Development;Disease;Economics;Education;Educational workshop;effectiveness evaluation;Evaluation;experience;Faculty;Funding;Future;Goals;graduate student;Grant;Heart;Human Resources;Impact evaluation;improved outcome;Institution;Leadership;meeting abstracts;Mentors;Mission;Occupations;Pilot Projects;Policies;Principal Investigator;Procedures;Process;Program Development;Program Evaluation;Program Research Project Grants;programs;Publications;Recommendation;Research;Research Activity;research and development;Research Personnel;Resource Sharing;Resources;Services;Strategic Planning;Students;success;symposium;undergraduate student

PROJECT_TITLE: Delaware INBRE


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Regenerative Medicine

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Heart disease is a leading cause of death in the U.S., partly due to the inability of muscle cells in the adult heart to divide. In sharp contrast, muscle cells in young mice divide robustly after a heart attack and can regenerate. Completion of the proposed studies will identify proteins in the young mouse heart that promote cardiac cell division, with the hope of applying these findings to treat human cardiovascular diseases.

PI_NAMEs: ALI, SHAH RUKH (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Academic Medical Centers;Address;Administrative Supplement;Adult;Advisory Committees;Age;Apical;Award;Beta Cell;Binding;Biology;Blood Vessels;California;Candidate Disease Gene;Cardiac;Cardiac Myocytes;cardiac regeneration;Cardiology;Cardiovascular Diseases;career development;Cause of Death;Cell Count;Cell Cycle Arrest;Cell Death;Cell division;Cell Lineage;Cell secretion;Cell Transplantation;cell type;Cells;Cessation of life;Cicatrix;conditional knockout;Data;defined contribution;Deterioration;Development;Endothelial Cells;Endothelium;Excision;Exhibits;experience;experimental study;Failure;Fellowship;Fibroblasts;Genetic Models;healthcare burden;Healthcare Systems;Heart;Heart Diseases;Heart failure;heart function;Heart Transplantation;Human;IGF2 gene;Impairment;improved;Injury;insight;Insulin Receptor;Insulin-Like Growth Factor Binding Protein 3;Insulin-Like Growth-Factor-Binding Proteins;Internal Medicine;Ion Channel;ischemic cardiomyopathy;Knockout Mice;Knowledge;Laboratories;Laboratory Study;Life;Maps;Mechanics;Mediating;Mentors;Micro Array Data;Mitogens;Mitosis;Mitotic;Molecular;mouse model;Mus;Muscle Cells;mutant;Myocardial Infarction;Myocardial Ischemia;Natural regeneration;Neonatal;neonatal injury;neonatal mice;neonate;novel;novel therapeutics;old mice;Operative Surgical Procedures;Organ;Output;overexpression;paracrine;Patients;Pharmaceutical Preparations;Physicians;professor;Proliferating;Protein Family;Protein Secretion;Proteins;Receptor Signaling;Recombinant Insulin-Like Growth Factor;Recombinants;regenerative;regenerative therapy;Research;Residencies;response to injury;Role;San Francisco;Scientist;Serum;Signal Induction;Signal Pathway;Signal Transduction;Source;therapeutic candidate;Tissues;Training;Translating;Universities;Ventricular;Vocational Guidance;Writing

PROJECT_TITLE: Role of IGFBP3 in Neonatal Heart Regeneration

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE FROM PARENT GRANT Guaranteed Basic Income (GBI) could address deep systemic social and structural inequities that lead to health disparities in Black youth, with potential to improve the financial, mental and physical well-being of Black emerging adults during their critical period of transition to independence. This study includes implementation and evaluation of an innovative, multilevel intervention to address grave inequities in health by providing GBI and access to financial coaching, peer-support, and real-time monitoring of needs and referral to services. The project will provide critical data needed to understand the potential of GBI for Black youth and how to maximize its impact on health with targeted programming at a time when multiple municipalities are considering GBI legislation.

PI_NAMEs: LIBBY, MARGARET ;LIGHTFOOT, MARGUERITA A.;LIPPMAN, SHERI ANN (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;Administrative Supplement;Adult;Affect;Age;aged;Agreement;Anxiety;Area;arm;Black race;Cellular Phone;Censuses;Cities;cohort;Communities;community partners;comparison group;Coupled;critical period;Cross-Over Trials;Data;depressive symptoms;design;Development;Discrimination;Disparity;Distal;Economics;Education;Effectiveness;Eligibility Determination;Emergency Situation;emerging adult;Employment;Enrollment;Ensure;Equity;Evaluation;Exclusion;experience;Exposure to;Family;Family Planning;financial literacy;follow up assessment;follow-up;food insecurity;Future;Goals;Health;health disparity;health equity;health inequalities;Health Services Needs;Home;Homelessness;Hypertension;improved;Income;Individual;Inequity;innovation;Intervention;Interview;Investments;Knowledge;Literature;Low income;Maternal Health;meetings;Mental Health;Mental Health Services;Mentors;Modeling;Monitor;Movement;multidisciplinary;Municipalities;Obesity;Outcome;outcome disparities;Ownership;parent grant;Participant;Pathological anxiety;payment;peer learning;peer support;Personal Satisfaction;Persons;Phase;physical conditioning;Policies;Policy Maker;Population;Poverty;programs;prospective;Protocols documentation;Psyche structure;racism;Randomized;real time monitoring;repaired;Reporting;Research;response;Savings;scaffold;Security;service gap;Service provision;service utilization;Services;sexual and reproductive health;Sexually Transmitted Diseases;social;social determinants;Statutes and Laws;Stress;Structural Racism;System;Time;Training;Transcend;transition to adulthood;Trauma;violence exposure;Waiting Lists;Work;working group;young adult;Youth

PROJECT_TITLE: Increasing financial and health equity among low income black youth and young adults - Supplement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)-R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Genetics;Hypertension;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: The aging human brain is highly vulnerable to accumulating damage over time from diseases that affect the smallest vessels in the brain, which then contributes to poor thinking and dementia. Our project aims to understand how and why this happens by taking advantage of new state-of-the-art technologies and important research resources that we have collected over time, including 1) the measurement of thousands of proteins from cerebrospinal fluid, 2) measurement of gene expression in specific cells and locations of the human brain, and 3) examining rodent models of human disease. With these data we hope to better understand the aging brain and discover new ways to prevent dementia.

PI_NAMEs: CRUCHAGA, CARLOS ;GOYAL, MANU S;LEE, JIN-MOO  (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Affect;Aging;aging brain;aging population;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Anti-Hypertensive Agents;Arterioloscleroses;Arteriosclerosis;Autopsy;Biological Markers;Body Fluids;Brain;Brain region;brain tissue;Cells;Cerebral Amyloid Angiopathy;Cerebral small vessel disease;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Cerebrovascular Disorders;Cerebrovascular system;Cognitive;cohort;Collection;comorbidity;Complex;Data;Data Set;Dementia;Development;Diabetes Mellitus;Disease;druggable target;Gene Expression;Genes;Genetic Transcription;healthy aging;Hemorrhage;Histopathology;Human;human data;human disease;human model;Hypertension;Image;imaging biomarker;Impaired cognition;in vivo;in vivo Model;Inbred SHR Rats;Institution;interest;Intervention;Investigation;Liquid substance;Location;Measurement;Measures;Mental Health;metabolomics;Minocycline;Modeling;Molecular;Multiomic Data;multiple omics;Mus;neuroimaging;new technology;novel;open data;Parietal;Pathogenesis;Pathology;Pathway interactions;Pattern;pharmacologic;Phenotype;potential biomarker;prevent;Proteins;Proteomics;Research;Resolution;Resources;Risk;Risk Factors;Rodent;Rodent Model;Sampling;Specimen;Stroke;targeted treatment;Techniques;Technology;Thinking;Time;Tissues;transcriptome;transcriptomics;Universities;Vascular Dementia;vascular risk factor;Ventricular;Washington;white matter;White Matter Disease;White Matter Hyperintensity

PROJECT_TITLE: VCID Center Without Walls for Understanding and Leveraging Small Vessel Cerebrovascular Disease Mechanisms in ADRD

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-M (21)]


NIH_SPENDING_CATS: Genetics;Prevention

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Here we are requesting an equipment supplement to purchase a new ultra-low freezer to use in performance of the projects described in the parent grant. Use of this new freezer is essential to our ability to work in an efficient manner. This work is relevant to NIGMS’s mission to support basic research that increases our understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention.

PI_NAMEs: RANKIN, SUSANNAH  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Basic Science;Biological Process;Cell division;Cell Line;Cells;Chromosome Segregation;Chromosomes;cohesin;cohesion;Development;disease diagnosis;DNA biosynthesis;DNA Repair;Ensure;Equipment;Foundations;Funding;genetic approach;Genetic Transcription;Mediating;Mission;Molecular;Molecular Genetics;National Institute of General Medical Sciences;Nuclear Structure;Outcome;parent grant;Parents;Performance;Play;Prevention;protein complex;Proteins;Regulation;repaired;Request for Applications;Role;Sister Chromatid;System;Testing;Vertebrates;Work

PROJECT_TITLE: Mechanisms of cohesin regulation in vertebrates

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Congenital Heart Disease;Genetics;Heart Disease;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MADISON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE Disease of the heart is the leading cause of death in the United States. The proposed research will help us better understand how a protein contributing to proper heart rhythm is produced in cardiac cells, while defects in its formation can lead to abnormal heart beating and sudden death.

PI_NAMEs: FLORES ALDAMA, LISANDRA  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Action Potentials;Affect;Affinity;Arrhythmia;Behavior;Biogenesis;Biophysics;Calorimetry;Cardiac;Cardiac Myocytes;Cardiovascular system;career;Cause of Death;Cells;Complex;Defect;design;disease model;Electrophysiology (science);Ethers;experimental study;Fluorescent in Situ Hybridization;Genes;Goals;Grant;Half-Life;Health;Heart Abnormalities;Heart Diseases;heart rhythm;Human;human induced pluripotent stem cells;hybrid protein;Immunoprecipitation;Impairment;In Vitro;Ion Channel;Link;live cell imaging;Long QT Syndrome;Mediating;Messenger RNA;Molecular;mRNA Stability;Mutagenesis;Myocardium;Phase;posttranscriptional;Potassium;Proteins;reconstitution;Research;ribosome profiling;RNA;RNA-Binding Proteins;Shapes;single molecule;skills;Specificity;Structure;Sudden Death;System;Transcript;Translations;Type 2 Long QT syndrome;United States;Ventricular;Western Blotting

PROJECT_TITLE: Biogenesis of hERG1a/1b ion channels in health and disease model cardiomyocytes


NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Primary Health Care;Social Determinants of Health

PHR: PROJECT NARRATIVE - PARENT AWARD Asthma affects 25 million patients in the United States; however, the effects of asthma are inequitably experienced with asthma disproportionately burdening patients living in lower-resource communities. In this career development award, the candidate and his mentoring team will partner with a network of federally qualified health centers in St. Louis, Missouri to assess if the single maintenance and reliever therapy (SMART) implementation bundle improves providers’ prescription of guideline-recommend SMART (Aim 1, 1° effectiveness outcome) while concomitantly using the RE-AIM framework to evaluate implementation outcomes including adoption (Aim 2, 1° implementation outcome). The potential impact of this study is high for the scientific community, local community health centers, and the applicant as it provides the mentored training needed to prepare him to subsequently lead an R01-level hybrid effectiveness-implementation trial for guideline-recommend SMART therapy.

PI_NAMEs: KRINGS, JAMES  (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Address;Adoption;Affect;American Lung Association;Area;Asthma;asthma exacerbation;asthmatic patient;Award;Black race;career;career development;Caring;Cessation of life;Cities;Clinic;Clinical;cluster randomized design;Cluster randomized trial;Communities;community academic partnership;community based participatory research;cost;Critical Care;design;Development Plans;didactic education;disadvantaged background;Education;Educational Status;effectiveness evaluation;effectiveness outcome;effectiveness/implementation trial;Electronics;Emergency Care;Emergency department visit;Equity;evidence base;experience;Faculty;Federally Qualified Health Center;Feedback;Fostering;Funding;Future;Goals;Guidelines;Health;health care disparity;Household;Hybrids;implementation evaluation;implementation framework;implementation outcomes;implementation science;improved;improved outcome;Individual;Inequity;Inhalators;innovation;Institution;K-Series Research Career Programs;Knowledge;Lead;long-standing disparities;low socioeconomic status;Lung;Maintenance;medical schools;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;Missouri;National Heart, Lung, and Blood Institute;Neighborhood Health Center;Outcome;Outcome Assessment;parent project;patient oriented;Patient risk;Patients;Pattern;Persons;Physicians;Population;Prevention education;Prevention program;professor;programs;Provider;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Relative Risks;Research;Research Methodology;Research Personnel;Research Project Grants;Resource Development;Resource-limited setting;Respiratory Disease;Risk;Schools;Scientist;Supervision;tool;Training;United States;United States National Institutes of Health;Universities;Update;Washington;Work

PROJECT_TITLE: Implementation of SMART therapy for asthma patients in low-resource community health centers


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Infectious Diseases;Lung;Pediatric;Pneumonia;Pneumonia and Influenza;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: From Parent Agreement PROJECT NARRATIVE Pneumonia is the leading infectious cause of death among children living in low-income countries, and those who survive pneumonia are at higher risk of developing chronic lung disease. Nearly 3 billion people worldwide cook with biomass fuels, and breathing smoke from biomass cookstoves may affect lung development in children, particularly in children recovering from pneumonia. This project will study how pneumonia and cookstove smoke affect lung development of children in Uganda, and whether an intervention to reduce cookstove smoke exposure in order to improve lung development is feasible in this population.

PI_NAMEs: MOSCHOVIS, PETER P (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Affect;Africa South of the Sahara;Agreement;biomass fuel;biomass smoke;Breathing;career;Cause of Death;Child;Child Development;Child Health;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;Clinical;Clinical Trials Design;Cohort Studies;Collaborations;cooking;Cookstove;Data;Development;early childhood;Educational workshop;Epidemiology;Exposure to;Family;fine particles;Foundations;General Hospitals;Goals;Growth;health difference;high risk;Household Air Pollution;Impairment;improved;Infant;International;Intervention;Intervention Trial;K-Series Research Career Programs;low and middle-income countries;low income country;Lung;lung development;Massachusetts;Measures;medical schools;Mentors;National Heart, Lung, and Blood Institute;Observational Study;Parents;Particulate Matter;patient oriented;Persons;Physiology;Pneumonia;Population;prevent;Primary Prevention;pulmonary function;Qualitative Research;Research;Research Methodology;Research Personnel;Resource-limited setting;Resources;respiratory;respiratory health;Respiratory Signs and Symptoms;Risk;Science;skills;Smoke;Strategic vision;Technology;Testing;Training;Uganda;Universities

PROJECT_TITLE: The effect of household air pollution on lung function growth in infants with pneumonia in sub-Saharan Africa.


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative This application addresses critical needs in the management of patients suffering from knee osteoarthritis (OA). The main goal of this proposal is to develop sPLA2 inhibitor-loaded micellar nanoparticles (sPLA2i-NPs) for knee osteoarthritis therapy.

PI_NAMEs: CHENG, ZHILIANG  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Address;Animal Model;Anti-Inflammatory Agents;Arthralgia;arthropathies;articular cartilage;Cartilage;chronic inflammatory disease;Clinical;clinical application;Clinical Research;clinical translation;clinically relevant;Data;Degenerative polyarthritis;Disease;Drug Delivery Systems;drug development;efficacy evaluation;Engineering;Enzymes;Esters;Goals;guinea pig model;Human;Inflammation;Inflammation Mediators;Inflammatory;Injury;joint function;joint inflammation;Joints;Knee Osteoarthritis;knee replacement arthroplasty;Life;Lysophospholipids;meter;Modeling;Mus;nanoparticle;Nanotechnology;new therapeutic target;Nonesterified Fatty Acids;Pain;Pathogenesis;Pathway interactions;Patients;Penetration;Pharmaceutical Preparations;Phospholipase A2;phospholipase A2 inhibitor;Phospholipids;preclinical study;prevent;Role;standard of care;Testing;Thick;Tissues;Up-Regulation;Work

PROJECT_TITLE: Treating knee osteoarthritis by sPLA2 inhibitor-loaded micellar nanoparticles


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative/Public Health Relevance The “UCLA-UCI Center for Eliminating Cardiometabolic Disparities in Multi-Ethnic Populations” (UC END- DISPARITIES) will address the inequitable multilevel factors, including structural disadvantage, that accelerate the development and progression of cardiometabolic disease and disproportionately affect low- income and minority groups. The center will function across the highly diverse communities that comprise Los Angeles County and Orange County (combined population of over 13 million, more than 46 states). UC END- DISPARITIES will work to prevent cardiometabolic disease, reduce its harmful impact in minority communities, and develop equitable community-partnered research approaches to meet these objectives via three integrated cores, three center research projects, and training programs for new investigators, all working to develop innovative community-relevant approaches to cardiometabolic disease prevention and treatment for southern California's vulnerable communities and at-risk patient populations.

PI_NAMEs: BODEN-ALBALA, BERNADETTE MARIE;BROWN, ARLEEN F. (contact);NORRIS, KEITH C

PROGRAM_OFFICER_NAME: HUELSNITZ, CHLOE OLIVIA

PROJECT_TERMS: Acceleration;acute care;Address;Adult;adverse outcome;Affect;Ambulatory Care;American Indian community;Asian;Atherosclerosis;Behavioral;beneficiary;Biometry;Black race;built environment;California;Cardiology;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular system;care costs;care outcomes;career;Caring;Chronic Disease;Chronic Kidney Failure;Clinical;Clinical Sciences;Collaborations;Communities;community engaged research;community engagement;Community Health Systems;Complex;County;design;Development;Diabetes Mellitus;Disadvantaged;disease disparity;disorder prevention;Disparity;disparity reduction;Drug Prescriptions;Economics;effectiveness evaluation;Emergency department visit;Enrollment;Epidemic;Equity;Ethnic Population;Evaluation;experience;Family;Funding;Future;Goals;Guidelines;Health;health care availability;health care service;health disparity;health equity;Health equity research;Health Expenditures;health information technology;Health Policy;health record;Health Services;Health system;Heart failure;Homelessness;hospital readmission;Hospitalization;hospitalization rates;Housing;Hypertension;implementation science;improved;Individual;Inequity;innovation;interest;Intervention;Investments;Latino;Length of Stay;Los Angeles;Low income;marginalized population;Measures;Medicaid;Medical;Mentorship;Methodology;Minority;minority communities;Minority Groups;Minority-Serving Institution;Morbidity - disease rate;mortality;multi-ethnic;National Institute on Minority Health and Health Disparities;Neighborhoods;Oranges;Outcome;Pacific Islander;parent grant;Participant;patient oriented;patient population;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pilot Projects;Policy Maker;Population;Postdoctoral Fellow;premature;prevent;Primary Care;primary care provider;primary health service;programs;public health relevance;Quasi-experiment;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;residence;Risk;Risk Factors;screening;Self Care;social;Social Conditions;social health determinants;social vulnerability;Social Work;Standardization;synergism;tool;Training;Training Programs;Translational Research;United States;Visit;vulnerable community;waiver;Work

PROJECT_TITLE: UCLA-UCI Center for Eliminating Cardiometabolic Disparities in Multi-Ethnic Populations (UC END DISPARITIES)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: Vascular contributions to cognitive impairment and dementia are driven by a spectrum of cerebral small vessel disease ranging from vessel injury to widespread brain changes. White matter vascular lesions that result from cerebral small vessel disease are triggered by defined and druggable molecular pathways in brain blood vessels and the neurons and networks that define this spectrum. This proposal will establish a translational framework for understanding these mechanisms of cerebral small vessel disease, share this understanding and the tools developed with the VCID community and the public, and advance new therapeutic strategies for VCID.

PI_NAMEs: CARMICHAEL, STANLEY THOMAS;HINMAN, JASON D (contact)

PROJECT_TERMS: Acceleration;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Animal Model;Automobile Driving;Autopsy;axon injury;Behavior;Blood Vessels;Brain;brain dysfunction;BRAIN initiative;Brain region;brain repair;Calcium;Cell Communication;cell injury;cell repository;Cells;Cerebral small vessel disease;Cerebrovascular system;Cerebrovascular Trauma;Cerebrum;Characteristics;Chronic;Clinical;clinical translation;cognitive task;Communication;Communities;comorbidity;Data;Data Set;Dementia;Diabetes Mellitus;diagnostic strategy;Disease;disease model;disease phenotype;Drug Targeting;Early identification;Edema;efficacy testing;Endothelial Cells;Endothelium;Environment;frontal lobe;Functional disorder;Genetic;Goals;Homeostasis;Human;human subject;Hypertension;Image;image translation;imaging biomarker;Imaging technology;Impaired cognition;Impairment;Inbred SHR Rats;Infarction;Inflammation;Inflammatory;Injury;intercellular communication;Ischemia;Knowledge;Lesion;Link;Location;Magnetic Resonance Imaging;Measures;Mediating;Modeling;Molecular;Molecular Target;Mus;Nerve Degeneration;network dysfunction;neuroinflammation;Neuronal Dysfunction;Neurons;neuropathology;neurovascular;new therapeutic target;novel;novel therapeutic intervention;Nuclear RNA;Obese Mice;Obesity;Pathogenesis;Pathologic;Pathology;Pathway interactions;Pattern;Performance;Permeability;Phenotype;Physiological;Rattus;Recurrence;regional difference;Research;Research Personnel;Research Proposals;resilience;Resolution;response;Rodent;Rodent Model;Role;Running;Series;Severities;Short-Term Memory;Signal Transduction;single cell sequencing;Synapses;System;Task Performances;tau Proteins;Tauopathies;Technical Expertise;Techniques;Temporal Lobe;Testing;Therapeutic;therapeutic candidate;therapeutic target;Therapeutic Uses;Tissues;tool;tractography;trait;transcriptome sequencing;Transgenic Organisms;translational framework;Treatment Efficacy;two-photon;vascular cognitive impairment and dementia;vascular inflammation;Viral;Viral Genes;Water;web site;webinar;white matter;Work

PROJECT_TITLE: Defining the molecular spectrum of white matter vascular lesions


ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative Recently, it has been realized that bacterial sensing and adaptation to environmental fluctuations is promoted by condensates, which are structures that concentrate proteins and nucleic acids. However, due to their extremely small size and dynamic interactions, current methods are unable to provide insights into the exact workings of condensates in bacteria. This proposal aims to observe the structure, dynamics, and interactions of bacterial condensates at utmost resolution, ultimately shedding light on their role in the adaptation of both free-living and host-associated bacteria.

PI_NAMEs: SAURABH, SAUMYA  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TITLE: Exploring the function of bacterial condensates in adaptation and evolution

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WINSTON-SALEM

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE First generation Mexican immigrants often experience psychological distress, as evident in suicide behaviors and depression and stress related to undocumented status while second generation Mexican immigrants also experience discrimination and financial stressors. Although these stressors may increase need for mental health services, these immigrants often do not receive appropriate services. This study will address unmet needs among 1st and 2nd generation Mexican immigrants, and factors that may limit their interest in or access to mental health services.

PI_NAMEs: HOWARD, TIMOTHY D;SANDBERG, JOANNE CHRISTINE (contact)

PROGRAM_OFFICER_NAME: MARTIN, IMAN

PROJECT_TERMS: Address;Anxiety;barrier to care;Behavioral;behavioral health;Caring;caucasian American;Communities;Data;Data Collection;data dissemination;Development;Epigenetic Process;Equity;experience;Exposure to;Future;Generations;Goals;Health;health care service;health equity;Health Insurance;Health Professional;help-seeking behavior;Immigrant;Immigration;Individual;interest;Intervention;Interview;Latinx;Literature;Manuscripts;Medical;medical specialties;Mental Depression;Mental Health;Mental Health Services;Mexican;Migrant;National Institute on Minority Health and Health Disparities;North Carolina;Outcome;parent grant;parent project;Participant;participant enrollment;Pattern;perceived discrimination;Personal Satisfaction;Persons;physical conditioning;Population;post-traumatic stress;Post-Traumatic Stress Disorders;psychological distress;Questionnaires;Religion;Research;research and development;Research Methodology;Research Personnel;Sampling;Science;Services;social stigma;Stress;stressor;Structure;success;suicidal behavior;symposium;Testing;Training;training opportunity;Trauma;trauma exposure;Violence;Work

PROJECT_TITLE: Migrant and Multi-generational Immigrant Experiences: The Effects of Stressors on Epigenetic, Behavioral, and Health-related Outcomes - Diversity Supplement

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: AMES

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE In contrast to major food-producing species such as cattle and swine, for which many antimicrobials are labeled for treatment of respiratory disease, there is currently only a single antibiotic (ceftiofur) approved by the FDA for treatment of respiratory disease in goats. Ceftiofur sodium requires daily administration which may decrease efficacy in situations where owner compliance with labeled instructions is lacking. Therefore, there is an urgent need for additional FDA-approved products for treatment of respiratory disease in goats.

PI_NAMEs: GORDEN, PATRICK J (contact)

PROGRAM_OFFICER_NAME: MARESCA, JANAH

PROJECT_TITLE: Concentration Determination of Tulathromycin Residues (CP-60,300) in Liver and Injection Site Tissues of Goats Receiving One Subcutaneous Injection of DRAXXIN 25 (25 mg/mL) at 2.5 mg/kg Bodyweight

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CVM-T (03)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cardiovascular;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Heart Disease;Infectious Diseases;Lung;Physical Activity;Rare Diseases;Tuberculosis

PHR: NARRATIVE: Heart and Lung Outcomes Post-Tuberculosis (HALO Post-TB) Half of people who complete treatment for pulmonary tuberculosis continue to have heart and lung symptoms with lower rates reported among people with HIV. Heart and lung function after completion of treatment for pulmonary tuberculosis and whether they vary by HIV status remain unknown. This project will determine the impact of HIV coinfection on heart and lung function at the end of treatment for tuberculosis using lung, heart, and exercise tests among a cohort of individuals in Kampala, Uganda and explore potential reasons for different post-TB heart and lung outcomes.

PI_NAMEs: HSUE, PRISCILLA Y. (contact);HUANG, LAURENCE ;SSINABULYA, ISAAC ;WORODRIA, WILLIAM

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acute;Age;Biological Markers;Biological Specimen Banks;Blood Vessels;candidate identification;Carbon Monoxide;Cardiac;Cardiopulmonary;cardiorespiratory fitness;Cardiovascular system;Categories;Chronic;Chronic lung disease;Classification;Clinical;clinical care;clinical predictors;co-infection;cohort;Collaborations;Country;Diffusion;Disease;Echocardiography;Enrollment;Event;Exercise;Exercise Test;Fibrosis;follow-up;Funding;Future;Goals;Heart;Heart failure;heart function;High Prevalence;HIV;HIV/TB;immunoreaction;improved;indexing;Individual;inflammatory marker;Infrastructure;International;Intervention;Longitudinal cohort study;Low Prevalence;Lung;Lung Diseases;lung volume;Machine Learning;Measures;Methods;Morbidity - disease rate;mortality;Outcome;Outcome Study;Participant;Pathway interactions;Pattern;persistent symptom;Persons;Phenotype;Plasma;Pleural;Prevalence;Productivity;pulmonary arterial pressure;pulmonary function;Pulmonary function tests;Pulmonary Heart Disease;Pulmonary Hypertension;pulmonary symptom;Pulmonary Tuberculosis;Questionnaires;Reporting;Research;Right ventricular structure;Risk Factors;Role;Sampling;sex;Spirometry;Stress;Structure;Survivors;Testing;Therapeutic;Tuberculosis;tuberculosis treatment;Uganda;United States National Institutes of Health;Walking

PROJECT_TITLE: Heart and Lung Outcomes Post-TB (HALO Post-TB)

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Pannexins are membrane channels widely distributed throughout the human body and play important roles in inflammation and neurotransmission. Our research objective is to understand mechanisms of how pannexins function at a molecular level, which may lead to the design of novel pharmacological agents to treat inflammatory and neurological diseases.

PI_NAMEs: KAWATE, TOSHIMITSU  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Biological Assay;Cell Membrane Permeability;Cells;chronic pain;Cryoelectron Microscopy;design;Disease;Electrophysiology (science);Family;Foundations;Goals;Human body;Hypertension;Inflammation;Inflammatory;inhibitor;innovation;insight;Ion Channel;Ion Channel Gating;Ligands;Link;Molecular;N-terminal;Nervous System Disorder;neurotransmission;novel;novel therapeutics;pharmacologic;Physiological;Play;Post-Translational Protein Processing;receptor;reconstitution;Regulation;Research;Role;screening;Signal Pathway;Signal Transduction;Signaling Molecule;Stimulus;Structure;tool;Tumor Necrosis Factor Receptor

PROJECT_TITLE: Structure and Function of Pannexins: Activation Mechanism

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: IRVINE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE A common feature across all living organisms is the central goal to maintain homeostasis and as a result the cell devotes significant energy to the regulation of protein lifespan. Lysosomes are specialized compartments in every eukaryotic cell that are essential for protein breakdown, yet major gaps in knowledge remain in our understanding of the mechanisms underlying protein delivery and trafficking to lysosomes. The proposed research investigates the molecular pathways, enzymes, and regulatory factors by leveraging a new protein tag for lysosomal delivery, which could contribute a fundamental aspect of cellular homeostasis and for developing tools to control protein levels in biological research. 12

PI_NAMEs: ALBRECHT, LAUREN VERONICA (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Address;Amino Acid Sequence;Area;Arginine;biological research;Biology;Cells;Communities;Complex;Cytosol;Enzymes;Eukaryotic Cell;field study;Goals;Growth;Homeostasis;improved;innovation;insight;Knowledge;life span;lysosomal proteins;Lysosomes;Metabolic Pathway;Methylation;Modeling;Molecular;multicatalytic endopeptidase complex;novel;Organism;Pathway interactions;Peptides;Post-Translational Protein Processing;prevent;Process;Proliferating;Protein Biosynthesis;protein degradation;Proteins;Proteolysis;Proteome;public database;Regulation;Research;Research Personnel;Resources;response;Signaling Protein;spatiotemporal;Stimulus;Substrate Specificity;System;Testing;tool;trafficking;Ubiquitin;ubiquitin-protein ligase;Work

PROJECT_TITLE: Deciphering Novel Principles of Rapid Proteostatic Control and Innovating Spatiotemporal Lysosomal Tools

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Radiation Oncology;Rare Diseases;Rehabilitation

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE (PARENT GRANT) This study will develop and validate novel cardiovascular disease risk prediction models that incorporate cardiac substructure doses. By translating this work to the clinic, we can optimize radiotherapy planning for newly diagnosed children and recommend risk profile-based counseling for survivors of childhood cancers.

PI_NAMEs: HOWELL, REBECCA MAUREEN (contact);MULROONEY, DANIEL A.;YASUI, YUTAKA

PROGRAM_OFFICER_NAME: SHELBURNE, NONNIEKAYE F

PROJECT_TERMS: adolescent patient;Aftercare;Anthracycline;Cancer Survivor;Cardiac;Cardiomyopathies;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;care providers;Cessation of life;chemotherapy;Chest;Child;Childhood;childhood cancer survivor;Chronic;Clinic;Clinical;clinical care;clinical practice;Coronary Arteriosclerosis;Counseling;Data Reporting;demographics;Disease Outcome;Dose;evidence base;Foundations;Future;Goals;Health;Heart;Heart Valve Diseases;Heterogeneity;in silico;Investigation;Life;Long-Term Survivors;Malignant Neoplasms;Modeling;Newly Diagnosed;novel;Organ;parent grant;Patients;personalized medicine;personalized risk prediction;Population;predictive modeling;premature;prospective;Radiation;Radiation therapy;Radiation Tolerance;Recommendation;Reporting;Research;response;Risk;Risk Assessment;risk mitigation;risk prediction;risk prediction model;Survivors;System;tool;Translating;treatment planning;web app;Work

PROJECT_TITLE: Research Supplements to Promote Diversity in Health-Related Research: Personalized Risk Prediction to Reduce Cardiovascular Disease in Childhood Cancer Survivors


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Prevention;Rehabilitation;Serious Mental Illness;Telehealth

ORG_CITY: ORLANDO

ORG_NAME: ADVENTHEALTH ORLANDO

ORG_STATE: FL

PHR: PROJECT NARRATIVE The proposed study will integrate a customized cognitive intervention with rigorous sample population phenotyping to target a distinct and prominent subgroup of apathetic depressed older adults at high risk of poor clinical and functional outcomes. In this K23 application, we will examine engagement of salience processing and executive control networks with digital cognitive training in older adults with apathy of late-life depression. This will provide preliminary data regarding brain network targets of a digital cognitive training program that may translate to mood and cognitive benefits, and may guide future development of non-pharmacologic treatments for apathy in older adulthood.

PI_NAMEs: OBERLIN, LAUREN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: affective disturbance;Aging;alternative treatment;anti-depressive agents;arm;Attention;attentional control;Behavior;Behavioral;Brain;career;Caregiver Burden;Caring;chronic depression;Clinical;clinical efficacy;Clinical Trials;clinically significant;Cognitive;cognitive benefits;cognitive control;Cognitive deficits;cognitive process;cognitive training;computerized;Consultations;Control Groups;Data;Depressed mood;depressed patient;depressive symptoms;design;Development;digital;digital delivery;digital treatment;disability;Disabling;Disease;Disease remission;Educational Intervention;efficacious treatment;Emotional;Evaluation;executive function;Exercise;Expectancy;functional decline;Functional disorder;Functional impairment;Functional Magnetic Resonance Imaging;functional outcomes;Future;Generations;geriatric depression;Goals;Health;high risk;Home;hospitalization rates;Impaired cognition;Impairment;improved;innovation;Insula of Reil;Intervention;Investigational Therapies;K-Series Research Career Programs;Knowledge;late life;Major Depressive Disorder;Medical;Mental Depression;Modeling;Mood Disorders;Moods;Morbidity - disease rate;motivated behavior;Motivation;National Institute of Mental Health;neglect;network dysfunction;Network-based;neuroimaging;Neurosciences;non-demented;Nonpharmacologic Therapy;novel;novel therapeutics;Nucleus Accumbens;older adult;Outcome;Participant;patient engagement;Patients;Performance;personalized medicine;Persons;Phenotype;Population;post intervention;predicting response;Prefrontal Cortex;primary outcome;Process;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;reduce symptoms;remote delivery;Research;Research Personnel;response;Rest;Rewards;Sampling;secondary outcome;sedentary lifestyle;Series;Severities;skills;social;Structure;Subgroup;support network;sustained attention;Symptoms;Syndrome;Technical Expertise;theories;therapeutic target;Training;Training Programs;training project;Translating;treatment strategy;Video Games;virtual delivery;web platform;white matter;Withdrawal

PROJECT_TITLE: Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE Plastic pollution and the breakdown of plastic materials primarily into micron-sized microplastic particles (MP) have contaminated our food and water sources, raising ecological and public health concerns. MP ingestion by humans is now an inevitable consequence of global plastic pollution and there is a critical gap in knowledge regarding how MP affects the gastrointestinal (GI) tract. The studies proposed in this NIEHS Diversity supplement grant application seek to understand how MP influence enteroendocrine cells and how the gut barrier sterilizes MP before entering into the body.

PI_NAMEs: CASTILLO, ELISEO F (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Address;Affect;Applications Grants;Area;Award;Biochemical;Bioinformatics;Biology;career;career development;Cell Lineage;Cells;Communication;design;Development;Development Plans;doctoral student;Enteroendocrine Cell;Environmental Health;Epithelium;experience;Food;Funding;Gastrointestinal tract structure;Gene Expression;General Population;Goals;gut health;gut inflammation;Health;health knowledge;Human;in vivo;Individual;Ingestion;insight;intestinal barrier;Intestines;Knowledge;Lamina Propria;Mentors;Molecular;Mus;National Institute of Environmental Health Sciences;New Mexico;Organoids;particle;Plastics;Pollution;Positioning Attribute;Predisposition;Public Health;Publications;Research;Research Project Grants;Research Training;response;Risk;Science;single-cell RNA sequencing;Source;stem cell differentiation;success;Tissues;Training;undergraduate research;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Water

PROJECT_TITLE: Diversity Supplement - Diego Ruiz

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(05)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: The proposed research focuses on understanding cerebral amyloid angiopathy (CAA), a condition common in Alzheimer's disease that affects the brain’s blood vessels. By combining advanced techniques that have only recently become available—such as human brain single-cell genomics and reversible mouse models of CAA— we will elucidate how dysfunction of specific immune and vascular cells in the brain regulates the formation and clearance of CAA. Because neurodegenerative and vascular pathologies often co-exist in the aged brain, our findings may guide the development of new biomarkers and therapeutic targets for Alzheimer’s disease, CAA, and mixed pathology dementias.

PI_NAMEs: ARFANAKIS, KONSTANTINOS ;BLURTON-JONES, MATHEW MARK;HUANG, YADONG ;SCHNEIDER, JULIE A.;YANG, ANDREW CHRIS (contact)

PROJECT_TERMS: abeta accumulation;Abeta clearance;abeta deposition;Address;Affect;Age;aging brain;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein;Animal Model;Antibody Therapy;Apolipoprotein E;apolipoprotein E-4;Autopsy;Biological Markers;Biology;Blood;Blood Vessels;Brain;brain cell;case control;Cell Physiology;cell type;Cells;Cerebral Amyloid Angiopathy;cerebrovascular;Cerebrovascular Disorders;cerebrovascular pathology;Cerebrovascular system;clinical imaging;Code;Cognitive;combinatorial;Data;Data Set;Dementia;design;Development;Disease;Equilibrium;experimental study;frontal lobe;Functional disorder;gain of function;Gene Expression;Gene Expression Profile;Generations;Genetic;Genomic approach;Genomics;Genotype;healthy aging;Hemorrhage;Human;human tissue;Image;Immune;Immunotherapy;Impaired cognition;Impairment;insight;loss of function;Macrophage;Magnetic Resonance Imaging;Mediating;Microglia;mixed dementia;Modeling;Molecular;Molecular Analysis;Molecular Profiling;mouse model;multidisciplinary;Mus;Nerve Degeneration;Nervous System Disorder;neuroinflammation;Neurons;neuropathology;neurovascular unit;novel strategies;Pathologic;Pathology;Pathway interactions;Plasma;prevent;Process;Protocols documentation;Publications;Research;Risk Factors;Route;Safety;Sampling;Senile Plaques;sex;single cell genomics;single nucleus RNA-sequencing;Structure;synergism;Techniques;therapeutic target;Toxic effect;translational potential;Vascular Diseases

PROJECT_TITLE: Vascular-immune mechanisms of cerebral amyloid angiopathy and Alzheimer's pathology


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Pediatric;Pediatric - AIDS

ORG_CITY: DAVIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: We are seeking a safe and effective agent to combat human immunodeficiency virus (HIV), which has killed about 35 million people. We are developing a treatment that removes HIV-infected cells from the bodies of infected infants, in hopes of achieving durable remission of the infection. In this grant we will rigorously and separately test the potential of the treatment to remove reservoir cells and to induce remission, and test if its efficacy can be further improved by addition of a broadly neutralizing antibody.

PI_NAMEs: HARTIGAN-O'CONNOR, DENNIS J. (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: Address;Animals;Antibody Therapy;arm;Binding;Biological Assay;Bispecific Antibodies;CCR5 gene;CD3 Antigens;Cells;clinical development;combat;Cytotoxic T-Lymphocytes;Data;Disease remission;early screening;Excision;experimental study;Gene Expression;Goals;Grant;HIV;Human;Immune;Immunity;improved;Infant;infant animal;infant infection;Infection;innovation;interest;Interruption;large scale production;latent HIV reservoir;Lymphopenia;Macaca;manufacture;mathematical model;Measurable;Measures;Membrane Proteins;Modality;Monoclonal Antibody HuM291;neutralizing antibody;neutralizing monoclonal antibodies;Persons;pharmacokinetics and pharmacodynamics;Play;preclinical study;Preparation;Randomized;reactivation from latency;Regimen;Remission Induction;Reporting;Research;Role;Safety;side effect;simian human immunodeficiency virus;SIV;success;T cell therapy;T-Lymphocyte;Testing;therapeutic vaccine;Time;Vaccines;Viral Load result;Viral reservoir;Virus Replication;Work

PROJECT_TITLE: Understanding reservoir effects and curative potential of a CD3/CCR5 bispecific antibody in infant macaques

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-X (03)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Complementary and Integrative Health;Dietary Supplements;Nutrition;Prevention

ORG_DEPT: ZOOLOGY

PHR: Narrative Effective meta-analysis improves precision of estimates of effect of the biomarkers studied, reveals data pattern and generalizability of biomarkers not identified through individual studies, addresses contradictions found in multiple individual studies, and generates new hypotheses. We will leverage the published results and raw data of oxylipins in both human subjects and animal models studies from the last 2 decades to evaluate and re-assess the role oxylipins play in disorders of human health. Our comparative study design will also enable inferences on the effects nutritional interventions have on clinical phenotypes and oxylipin cascade.

PI_NAMEs: HAMMOCK, BRUCE D (contact);SHIH, PEI-AN (BETTY)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Address;Affect;analytical method;Animal Model;Animals;Anorexia Nervosa;Biological Assay;Biological Markers;candidate selection;Categories;Chemicals;Chronic Disease;Clinical;clinical biomarkers;clinical phenotype;Comparative Study;Cytochrome P450;Data;data modeling;dietary;Dietary Intervention;Disease;Environmental Exposure;Epidemiologist;epidemiology study;Fatty Acids;Glycols;Goals;Health;Human;human disease;human subject;hydroxy fatty acid;improved;Individual;Inflammation;Inflammatory;Intervention;Knowledge;Laboratories;Link;Lipids;Lipoxygenase;Literature;Mass Spectrum Analysis;Meta-Analysis;metabolomics;Mission;Modeling;National Institute of Environmental Health Sciences;nutrition;Omega-3 Fatty Acids;Organ;Paper;parent grant;Pathway interactions;Patients;Pattern;pharmacologic;Phenotype;Play;Prevention strategy;Process;Prostaglandin-Endoperoxide Synthase;Prostaglandins;Publishing;Regulation;Reproducibility;Research;Research Design;Resolution;Review Literature;Risk;Rodent;Role;sample collection;Severities;Signal Transduction;Study models;Study Subject;Supplementation;Symptoms;targeted treatment;Technology;Testing;Tissues;Toxic effect;treatment strategy;Work;Xenobiotics

PROJECT_TITLE: Supplement for bioactive lipids as effectors and indicators of the deleterious effects of human health


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: SCOTTSDALE

ORG_NAME: VITALANT

ORG_STATE: AZ

PHR: PROJECT NARRATIVE While the advent of antiretroviral therapy (ART) has significantly decreased the morbidity and mortality associated with HIV infection, the virus is never completely eliminated from the body of the infected individual, necessitating lifelong drug treatment. In this study, we will comprehensively examine the impact of modulating galectin-9 (Gal-9), an immunoregulatory β-galactoside-binding lectin, as a therapeutic approach to accelerate clearance of the latent HIV reservoir, resolve HIV-associated inflammation, and prevent viral rebound following ART discontinuation. Our findings will guide the development of novel HIV cure strategies that leverage the immunomodulatory activities of host galectins.

PI_NAMEs: NDHLOVU, LISHOMWA C;PILLAI, SATISH KUMAR (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Acceleration;age acceleration;antagonist;antiretroviral therapy;antiviral immunity;Attenuated;Binding;CD4 Positive T Lymphocytes;Cell Compartmentation;Cell Proliferation;Cell surface;Cells;Chronic;Clinical;Data;design;Development;Disease remission;DNA;Epithelial Cells;Epithelium;experience;Galactose Binding Lectin;Genetic Transcription;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;HIV;HIV Infections;Human;humanized mouse;Immune;Immunologics;immunoregulation;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Integration Host Factors;interest;Interleukin-15;intestinal epithelium;intestinal injury;Kinetics;latent HIV reservoir;Maintenance;Mediating;Medicine;Modeling;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Mus;Myelogenous;novel;Pathogenesis;Persons;Pharmacotherapy;Plasma;Polysaccharides;prevent;Recombinants;Research Institute;RNA;Role;Sampling;Signal Transduction;Site;Supplementation;Systems Biology;T-Lymphocyte;Therapeutic;Time;Tissue Sample;Tissues;tool;Universities;Viral;viral rebound;Virus;Work

PROJECT_TITLE: Modulation of Galectin-9 to Target HIV Persistence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-D (02)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: PHOENIX

ORG_NAME: TRANSLATIONAL GENOMICS RESEARCH INST

PHR: PROJECT NARRATIVE The longevity consortium will seek to integrate data and findings across 5 projects with different approaches to identifying factors influencing human longevity (studies of different species, drug testing, cell models, human association studies, and human studies of exceptional longevity and Alzheimer’s disease and related dementias). An integrated analysis and administrative core will facilitate appropriate interactions. The proposed level of integration is rarely seen in the biomedical sciences and will result in more reliable longevity-enhancing drug targets, candidate interventions, clinically useful biomarkers, and prediction models of health and longevity.

PI_NAMEs: GIRKE, THOMAS ;SCHORK, NICHOLAS JOSEPH (contact)

PROGRAM_OFFICER_NAME: DUTTA, CHHANDA

PROJECT_TERMS: Address;advanced analytics;Affect;age related;age-related disease;Aging;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;analytical method;Assessment tool;Behavioral;Biological;Biological Assay;Biological Factors;Biological Markers;Biology;canine model;Cell Line;Cell model;Cells;Centenarian;Clinical;clinical biomarkers;Cognitive;cognitive function;cohort;Collaborations;comparative;Complement;Complex;Data;Data Analytics;Data Collection;Data Coordinating Center;data harmonization;data integration;data portal;Data Set;data sharing;design;Disease;diverse data;DNA Repair;drug development;drug repurposing;Drug Screening;Drug Targeting;drug testing;Exhibits;extreme human longevity;follow-up;Funding;Genetic;Genetic Transcription;Genome;genome wide association study;genomic data;Genomics;geroprotector;Health;healthspan;Human;human disease;Human Genome;human old age (65+);improved;Individual;Induced Neurons;induced pluripotent stem cell;Informatics;Infrastructure;insight;interoperability;Intervention;Life;life span;Light;Literature;Longevity;Mediating;Methods;Methylation;Molecular;Monitor;Multiomic Data;multiple data sources;Mus;Neurons;novel;online resource;Outcome;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phenotype;physical conditioning;Population;pre-clinical;Predictive Factor;predictive modeling;Predictive Value;Process;rate of aging;Recording of previous events;Research;Research Design;Research Personnel;resilience;Resources;response;Risk;Risk Assessment;Science;Severities;sex;species difference;success;System;Systems Biology;Techniques;Test Result;Testing;Therapeutic;therapy development;tool;Training;Validation;Variant;Work;working group

PROJECT_TITLE: Longevity Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (A1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

PI_NAMEs: SCHORK, NICHOLAS JOSEPH (contact)

PROJECT_TERMS: Academia;Budgets;cheminformatics;Collaborations;Communication;Communication Programs;Communities;Consensus;Contracts;Data;data sharing;Educational workshop;experience;experimental study;Fostering;Foundations;Funding;Funding Opportunities;Goals;Industry;Laboratories;Lead;Leadership;Longevity;meetings;member;Monitor;Observational Study;operation;organizational structure;Outcomes Research;outreach;Persons;Pharmacologic Substance;Procedures;programs;Progress Reports;Publications;Quality Control;Reporting;Research;Research Personnel;Resource Sharing;Resources;Role;Schedule;Scientist;symposium;Synapses;Time;timeline;tool;translational approach;translational potential;Trust;U-Series Cooperative Agreements;United States National Institutes of Health;video chat;web site;Work;working group

PROJECT_TITLE: Longevity Consortium Administrative Core


PI_NAMEs: LAPIDUS, JODI A (contact)

PROJECT_TERMS: Address;Age;age related;age-related disease;Aging;aging related;aging related disease;Attention;biobank;Biological;Biological Aging;Biological Factors;Biological Markers;biomarker identification;Blood;Body Composition;cardiovascular health;Chronic;Clinical;Cognitive;cohort;Cohort Studies;Collaborations;comorbidity;Data;Data Analyses;data harmonization;data resource;Data Set;Data Sources;Dependence;design;Diagnosis;Disease Resistance;Drug Targeting;Elderly;Environmental Risk Factor;Exhibits;frailty;Genetic;Genetic Variation;genome wide association study;genome-wide;Genomics;Genotype;geroprotector;Goals;Health;Health and Retirement Study;health assessment;Health Benefit;healthspan;Human;Human Characteristics;International;Intervention;Life Expectancy;Light;Longevity;Machine Learning;Measures;men;metabolomics;Methodology;Methods;Modeling;mortality;multiple chronic conditions;Muscle;Nature;non-genetic;osteoporosis with pathological fracture;Outcome;Pathway interactions;Performance;Persons;Phenotype;phenotypic data;Population;Population Heterogeneity;predictive marker;predictive modeling;Predictive Value;Predisposition;programs;Proteomics;Public Health;Registries;Research;resilience;Resources;Sampling;Scheme;Serum;sex;Social Environment;Statistical Data Interpretation;Subgroup;Techniques;translational potential;Underrepresented Populations;United States Centers for Medicare and Medicaid Services;Update;validation studies;Variant;whole genome;Work

PROJECT_TITLE: Human Longevity Associations, Trajectories and Predictions


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PI_NAMEs: TEWHEY, RYAN  (contact)

PROJECT_TERMS: Address;age-related disease;Aging;Algorithms;Balaena;Biocompatible Materials;Biological;Biological Assay;Biological Models;Biological Process;Biology;Cell Differentiation process;cell type;Cells;Chiroptera;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;Collection;comparative;comparative genomics;CRISPR screen;Data;data modeling;Databases;deep learning model;DNA Repair;drug development;Elements;Elephants;Evolution;experimental study;Fibroblasts;functional genomics;gene regulatory network;Genes;Genetic;Genetic Transcription;genetic variant;Genetic Variation;Genome;genomic data;genomic signature;genomic tools;Genomics;geroprotector;Health;Human;in silico;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;innovation;insight;Intervention;lens;Life;life span;Link;Longevity;longevity gene;mammalian genome;Mammals;member;Methodology;Methods;model building;model organism;Modeling;Mole Rats;Molecular;molecular phenotype;Multiomic Data;multiple omics;Mutagenesis;network architecture;Neurons;Pathway interactions;Phenotype;Phylogenetic Analysis;Population;Regulatory Element;Reporter;Research;Resources;species difference;Surveys;Taxonomy;Testing;Time;tool;trait;translational potential;Translations;Untranslated RNA;Variant;vertebrate genome

PROJECT_TITLE: Cross-Species and Evolutionary Biology


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PI_NAMEs: SEBASTIANI, PAOLA  (contact)

PROJECT_TERMS: Address;African ancestry;Age;Age of Onset;Aging;Alleles;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Biological Markers;Black Populations;Blood;Centenarian;cognitive function;cohort;Collection;Data;data harmonization;Data Linkages;Data Set;Disease;Enrollment;Environment;Ethnic Origin;exome;extreme human longevity;follow-up;Gene Combinations;Generations;Genes;Genetic;genetic analysis;Genetic Fingerprintings;genetic signature;genetic variant;Genetic Variation;Genome;genome-wide;genomic signature;Genomics;Genotype;Germ-Line Mutation;healthy aging;Human;human old age (65+);Impaired cognition;Individual;Investigation;Longevity;Medical History;metabolomics;Molecular;Multiomic Data;multiple omics;Not Hispanic or Latino;offspring;Participant;Phenotype;predictive marker;Predisposition;Productivity;Proteomics;Race;racial diversity;racial identity;Risk;risk prediction;Serum;Severities;sex;Somatic Mutation;synergism;Therapeutic;transcriptomics;translational potential;United States Centers for Medicare and Medicaid Services;Validation;Variant;Work

PROJECT_TITLE: Extreme Longevity, Cognitive Impairment, Alzheimer's Disease and Related Dementias


PI_NAMEs: MILLER, RICHARD A (contact)

PROJECT_TERMS: Adipose tissue;Adult;Age;Age Months;age related;age related changes;age related decline;aged;Aging;aging biomarker;aging population;Algorithms;Animals;anti aging drug;Award;biological age;Biological Assay;Biopsy;Brain;Brain region;Breeding;candidate validation;Canis familiaris;Cellular biology;Cephalic;Cessation of life;cheminformatics;Cognitive;cognitive ability;cognitive function;cognitive testing;cohort;Data;Data Sources;Development;Disease;disease model;drug candidate;Drug Exposure;Drug Targeting;drug testing;Elements;experimental study;extend lifespan;Failure;Fatty acid glycerol esters;fitness;Funding;Future;Genetic;genetic analysis;geroprotector;Goals;Health;healthspan;Heart;Histocytochemistry;Human;human old age (65+);human tissue;Impaired health;improved;in silico;Informatics;Intervention;Lead;life span;Liver;Longevity;Measures;Medical;member;Messenger RNA;metabolomics;Methods;middle age;Modeling;Molecular;Mus;Muscle;New Agents;new therapeutic target;novel;Outcome;Pathology;Pharmaceutical Preparations;Pharmacologic Substance;Physiological;Plasma;preservation;Procedures;Process;Property;Protocols documentation;Public Domains;rate of aging;Research;Resources;Safety;Sampling;Septuagenarian;Specimen;Testing;Therapeutic;Time;Tissue Sample;Tissues;Translating;translation to humans;Universities;volunteer;Work;young adult

PROJECT_TITLE: Drug Targeting, Testing, and Development


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: GAGE, FRED H (contact)

PROJECT_TERMS: Address;Aging;aging related;aging related disease;aging reversal;Alzheimer's disease related dementia;biological adaptation to stress;Biological Assay;Biological Models;biomarker identification;Cell model;Cell Physiology;Cells;Cellular biology;Clinical;combinatorial;Development;Disease;DNA Repair;Electrophysiology (science);Epigenetic Process;experience;Fibroblasts;flexibility;Genes;genetic variant;geroprotector;Geroscience;Human;Human Development;human induced pluripotent stem cells;human model;human old age (65+);In Vitro;Individual;Induced Neurons;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;innovation;Laboratories;Link;Longevity;Metabolic;Methodology;mild cognitive impairment;Modality;Modeling;Molecular;Neurons;next generation;novel;Pathway interactions;Peripheral Blood Mononuclear Cell;personalized therapeutic;Population;Prevention;Process;Productivity;Property;Proteins;Regenerative Medicine;resilience;resilience biomarker;Resistance;Signal Pathway;skills;Source;stem cell model;System;Testing;transcription factor;Validation;validation studies;virtual intervention;Work

PROJECT_TITLE: Cell Biology and Functional Analysis


PROJECT_TERMS: Address;age related;Alzheimer's disease related dementia;analytical method;Biological Markers;Cells;Clinical;Collaborations;Complex;Data;data access;Data Coordinating Center;data harmonization;Data Set;Disease;diverse data;Drug Targeting;Exhibits;Funding;Genetic;genetic association;genomic data;Genomics;geroprotector;Health;healthspan;heterogenous data;Human;Individual;Infrastructure;life span;Longevity;Mediating;Methods;Mus;non-genetic;novel;Pharmaceutical Preparations;Phenotype;Physiology;Population;predictive modeling;Process;rate of aging;Research;Research Personnel;Research Project Grants;Resources;response;Source;System;Systems Biology;trait;Work

PROJECT_TITLE: Integrative Analysis Core


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: The Veterans Benefits Administration (VBA) reports that, in Fiscal Year 2018, tinnitus was the most prevalent service-connected (SC) disability for all compensation recipients (1,971,201 Veterans), as well as the most prevalent SC disability among new compensation recipients (157,152 Veterans). Treatments claiming to reduce the sound of tinnitus show promise, but they need reliable measures of tinnitus features such as its loudness, pitch, and maskability. The previous study found age-specific standard ranges for these measurements using our computer-automated Tinnitus Evaluation System (TES). The new study will expand the previous study to: represent all age groups equally, obtain test-retest data over an extended period of time, test a pre-test training program for tinnitus pitch matching, and update the TES for ease of use in VA Audiology clinics. This project will result in more complete standards of tinnitus measurements and state-of-the-art equipment that will promote valid and reliable measurement of how tinnitus sounds to Veterans.

PI_NAMEs: FOLMER, ROBERT  (contact)

PROJECT_TITLE: Validation and Expansion of Established Norms for Measures of Tinnitus Perception

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]


ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PHR: Addiction continues to be a serious problem among Veterans and more treatment options are required. Promising new evidence suggests that stimulating the brain using electricity may be a new approach to treating mental health issues including addiction, but brain changes specific to some forms of addiction may limit the utility of this approach. A related approach of stimulating brain circuits using magnets may yield similar results and circumvent the addiction-specific issues. This project aims to test the feasibility and acceptability of synchronized Transcranial Magnetic Stimulation as a treatment for substance use disorders.

PI_NAMEs: MCGEARY, JOHN E (contact)

PROJECT_TERMS: acceptability and feasibility;addiction;Alcohol withdrawal syndrome;Alcohols;Behavior Therapy;Biological;Brain;Calibration;Clinical Trials;Cocaine;craving;cue reactivity;Cues;design;Devices;Disease;Dropout;Electricity;Feasibility Studies;feasibility testing;Future;Genetic;genome sciences;Goals;Impairment;improved;improved outcome;Infrastructure;Intervention;Measures;Mental Health;Modality;neural circuit;neuroregulation;neurorestoration;neurotechnology;noninvasive brain stimulation;novel strategies;Opioid;Participant;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Pilot Projects;Population;Protocols documentation;Psychotherapy;Quality of life;reduced substance use;rehabilitation research;Rehabilitation therapy;Relapse;repetitive transcranial magnetic stimulation;Research Proposals;response;Risk;Safety;Standardization;stimulant dependence;substance use;Substance Use Disorder;substance use treatment;success;Techniques;Testing;Transcranial magnetic stimulation;Treatment Cost;Treatment outcome;United States;Veterans;Work

PROJECT_TITLE: sTMS for Substance Use-disordered Veterans

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: Studies examining the relationship between psychiatric illness and suicide from the Department of Veterans Affairs indicate that individuals with bipolar disorder have the highest rate of suicide, which is even greater compared to post-traumatic stress disorder, schizophrenia and major depression. When left untreated, bipolar disorder has a 5-15% risk of death by suicide making it a top priority in Veterans' mental health care. Individuals with bipolar disorder behave impulsively – even during euthymic periods and understanding the relationship between impulsivity and suicidal behavior in bipolar disorder may assist in the identification of individuals at greatest risk for a future suicide attempt. We propose assessing both trait and state measures of impulsivity using self-report measures and functional magnetic resonance imaging to predict the occurrence of suicidal behavior longitudinally over 1 year in Veterans with bipolar disorder.

PI_NAMEs: SZESZKO, PHILIP R (contact)

PROJECT_TERMS: Accounting;Adult;Age;Aggressive behavior;Area;Behavioral;Behavioral Paradigm;Bipolar Disorder;blood oxygen level dependent;Brain region;causal model;Chlorpromazine;Clinical;Clinical assessments;density;discounting;Emotional;environmental change;Exanthema;experience;Fiber;follow-up;frontal lobe;functional disability;Functional Magnetic Resonance Imaging;Future;gray matter;Image;Impaired cognition;Impulsive Behavior;Impulsivity;Individual;Inferior frontal gyrus;Interruption;Left;Lithium;Machine Learning;Major Depressive Disorder;Measures;Medical Records;Meditation;Mental disorders;Mental Health Services;Modeling;Moods;mortality risk;Motor;negative affect;neural circuit;Neurites;Neurobiology;Neurocognitive;neuroimaging;Neuropsychology;novel;Outcome Measure;Patient Self-Report;Patients;Persons;Phenotype;Population;Post-Traumatic Stress Disorders;Psychoses;Recording of previous events;response;Rewards;Risk;Schizophrenia;Severities;sex;Signal Transduction;social;social cognition;suicidal act;suicidal behavior;suicidal morbidity;Suicide;Suicide attempt;suicide rate;Testing;trait;trait impulsivity;United States Department of Veterans Affairs;Ventral Striatum;Veterans;white matter;Work

PROJECT_TITLE: Predicting Suicidal Behavior in Veterans with Bipolar Disorder using Behavioral and Neuroimaging Based Impulsivity Phenotypes


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: Aurora

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The behavioral flexibility required to learn a new skill or to live in society is supported by an increase in neuronal activity within neuronal circuits. This neuronal activity induces structural changes in myelin and these changes in turn facilitate signal transmission, however, the cellular and molecular mechanisms underlying myelin plasticity are not well-understood. The experiments outlined in this proposal will capture the kinetics of RNA translation in vivo to determine if resident mRNAs contribute to myelin plasticity.

PI_NAMEs: ADULA, KADIDIA PEMBA (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;Action Potentials;Axon;Behavioral;Binding;Biological Assay;Brain;Cells;Central Nervous System;Co-Immunoprecipitations;Code;Communication;Complex;Data;Dendrites;developmental neurobiology;Diameter;electrical potential;Environment;experimental study;flexibility;Genes;Genetic;graduate student;Image;in vivo;Individual;insight;Instruction;Kinetics;Larva;Lasers;Learning;Length;Link;Lived experience;Location;loss of function;loss of function mutation;member;Messenger RNA;Molecular;motor learning;Mus;Mutate;Myelin;Myelin Sheath;myelination;Nature;Needs Assessment;neural circuit;neuronal circuitry;Neurons;neurotransmission;Oligodendroglia;paralogous gene;Pharmacogenetics;Positioning Attribute;Postdoctoral Fellow;postsynaptic;precursor cell;Process;Production;Protein Biosynthesis;Proteins;Proxy;Regulation;response;Ribosomes;RNA;RNA-Binding Proteins;Sensory;Signal Transduction;Site;skills;social;Societies;Stimulus;Structure;Synapses;Synaptic plasticity;System;Technology;Testing;Thick;Tongue;tool;Training;Transcript;transgene expression;Translations;transmission process;two-photon;vesicular release;Visualization;white matter;Work;Zebrafish

PROJECT_TITLE: Examining the regulation of resident mRNAs in myelinplasticity

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: Chronic ischemic wounds don't heal normally, causing significant pain and disability for many Veterans. Electrical stimulation (ES) is the only adjunctive treatment recommended for these severe ischemic wounds but has variable outcomes. We have developed and systematically tested a wearable untethered bandage enabling ES therapy to be delivered safely outside the clinic. We identified effective ES therapeutic paradigms to enhance healing and decrease wound infection. The next step, proposed in the current study, is to carry out preclinical translational development and testing of the Smart Modular Adaptive Electrotherapy Delivery System (SmartMAEDS) to concurrently treat and monitor chronic ischemic wounds. SmartMAEDS enables real-time remote monitoring of wound status, minimizing unnecessary dressing changes and wound bed disruption, improving healing outcomes and increasing patient safety. SmartMAEDS will reduce the burden of clinic attendance and the costs of delivering excellence in care to Veterans with chronic ischemic wounds.

PI_NAMEs: BOGIE, KATH  (contact)

PROJECT_TERMS: 3-Dimensional;Acute;Animal Model;Animals;Bacterial Infections;Bandage;battery life;biomaterial compatibility;Biomedical Technology;Blood gas;Caring;Chronic;chronic wound;Clinic;Clinical;clinical care;Clinical Practice Guideline;clinically relevant;Collaborations;Communication;Computer software;cost;cost outcomes;Curettage procedure;Custom;Data;decubitus ulcer;design;Development;Devices;Digital Photography;disability;Dryness;effective therapy;electric impedance;Electric Stimulation;Electric Stimulation Therapy;electronic stimulator;Electronics;encryption;Ensure;Face;Family suidae;Feedback;flexibility;Foundations;Frequencies;Genes;Granulation Tissue;healing;Healthcare;high standard;Histology;Immunohistochemistry;improved;improved outcome;in vivo;Infection;innovation;Instruction;integrated circuit;International;Intervention;Ischemia;Legal patent;Liquid substance;Long-Term Care;manufacture;Marketing;Methodology;Microbial Biofilms;microbial community;military veteran;Modification;Monitor;multidisciplinary;novel strategies;Outcome;Pain;patient safety;Patients;personalized care;personalized therapeutic;physical impairment;physically handicapped;porcine model;Positioning Attribute;Power Sources;pre-clinical;Pre-Clinical Model;preclinical development;preclinical evaluation;pressure;Process;programs;Protocols documentation;prototype;Rattus;real time monitoring;Recommendation;Recording of previous events;remote monitoring;research clinical testing;Risk;Running;safety testing;Secure;software development;Sterile coverings;Surface;Swab;System;Systems Development;Technology;technology platform;Temperature;Testing;theranostics;Time;Tissues;Translations;trend;Update;user-friendly;Veterans;wearable device;wireless;wireless communication;Work;wound;wound bed;wound care;wound dressing;wound healing;Wound healing therapy;Wound Infection;Wound models;wound treatment

PROJECT_TITLE: Toward smart personalized electrotherapy for enhanced healing of ischemic wounds

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences;Schizophrenia

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BARNARD COLLEGE

ORG_STATE: NY

PHR: Project Narrative A distorted sense of time and diminished capacity to anticipate the future are associated with a number of psychiatric disorders including substance abuse disorder, schizophrenia and depression. Distortions in timing and anticipation are both a symptom of the disorders as well as a source of additional problems. The purpose of this grant is to understand the basic brain mechanisms that underlie these capacities in order to discover new treatments.

PI_NAMEs: BALSAM, PETER D. (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Adaptive Behaviors;Animal Model;Association Learning;Attention deficit hyperactivity disorder;Behavior;Behavioral;Biological;Brain;Brain imaging;Cognitive;Conditioned Stimulus;Corpus striatum structure;designer receptors exclusively activated by designer drugs;Disease;Dopamine;drug of abuse;Event;Expectancy;experience;experimental study;Extinction;Foundations;Future;Grant;Hour;Human;information framework;information processing;Information Theory;interest;Knowledge;Learning;Maps;Measures;member;Memory;Mental Depression;Mental disorders;Modeling;motor behavior;novel therapeutic intervention;Performance;Process;psychologic;Research;response;reward expectancy;Rewards;Schizophrenia;sensor;Signal Transduction;Source;Speed;Stimulus;Substance abuse problem;Symptoms;Testing;Time;time interval;Time Perception;time use;Uncertainty;Work

PROJECT_TITLE: Timing & Associative Learning

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]