NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Women's Health Research

PROJECT_TERMS: Algorithms;Binding;Bioinformatics;Biological;Biology;breast cancer metastasis;Breast Cancer Model;cancer cell;Cell Communication;cell type;Cells;Cellular biology;Chromatin;Clinical;Colorectal Cancer;colorectal cancer metastasis;Computational algorithm;Computational Biology;Computing Methodologies;Data;Data Set;Disease;Distal;DNA;Elements;empowerment;experimental study;Fire - disasters;Gene Expression;Gene Expression Profiling;gene network;Generations;Genes;Genetic Transcription;Glean;innovation;insight;Interruption;Malignant Breast Neoplasm;Malignant Neoplasms;Metabolic;metabolic abnormality assessment;Metabolite Interaction;metabolomics;metastasis prevention;Metastatic to;Methodology;Methods;Modeling;Molecular;mRNA sequencing;Neoplasm Metastasis;novel;Organ;Pathway Analysis;Pathway interactions;pharmacologic;Phenotype;prevent;Primary Neoplasm;programs;Proteomics;Regulatory Element;Regulon;Reporter;Research Personnel;ribosome profiling;RNA;RNA-Binding Proteins;Series;single cell sequencing;Site;sound;System;Systems Biology;technology development;therapeutic target;transcription factor;transcriptome;transcriptomics;Universities

PROJECT_TITLE: Single-Cell & Computational Biology Core


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Pediatric;Prevention;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE. We propose two aims to conclude a series of 4 consecutive, separately funded studies, which enabled the gathering of decades of longitudinal data on young patients with juvenile-onset depression (JOD) from childhood until young adulthood. Aim 1 proposes to preserve and share the data (gathered across the first three studies) on these subjects, their full biological siblings, and controls, by depositing the data in the National Data Archives while Aim 2 involves the novel application of analytic tools from the machine learning toolbox to generate new, development-stage sensitive information about predictors of clinical and functional outcomes of JOD. Our project will preserve and make accessible unique longitudinal data on a particularly severe depression phenotype and yield developmentally informed knowledge about outcome predictors that can facilitate the prevention and treatment of JOD.

PI_NAMEs: KOVACS, MARIA  (contact)

PROGRAM_OFFICER_NAME: KIM, EUNYOUNG

PROJECT_TERMS: 14 year old;Adolescence;Adolescent;Affect;analytical tool;archive data;Archives;biobehavior;Biological;child depression;Childhood;Clinical;clinical predictors;Code;Collection;Communities;Competence;Complement;Data;data archive;Data Collection;data preservation;Data Set;data sharing;Databases;Deposition;Depressed mood;depressed patient;Depressive disorder;Development;Diagnosis;diverse data;DSM-IV;Early Intervention;Elements;emerging adulthood;emotion regulation;Enrollment;Family;follow-up;functional outcomes;Funding;Future;Goals;Grant;Hungary;Individual;Knowledge;Learning;learning strategy;Life;Link;longitudinal dataset;Machine Learning;Measures;Mental Depression;Modeling;novel;Outcome;outcome prediction;Participant;Patients;Persons;Phase;Phenotype;Policies;preservation;prevent;Prevention;preventive intervention;proband;Procedures;Process;programs;Psychiatric Hospitals;Psychopathology;Pythons;recruit;recurrent depression;Research Personnel;Risk;Risk Factors;Sample Size;Sampling;Series;Siblings;Specific qualifier value;Structure;United States National Institutes of Health;young adult

PROJECT_TITLE: Biobehavioral Inflexibility and Risk for Juvenile-Onset Depression

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Disease;Organ Transplantation;Social Determinants of Health;Substance Misuse;Transplantation

ORG_CITY: MADISON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Alcohol-associated liver disease (ALD) is a major cause of acute and chronic liver failure and is now the most common reason for liver transplantation in the U.S. Historically, transplant centers have required at least 6 months of alcohol abstinence before considering patients with ALD for liver transplant; however early liver transplant for patients with severe ALD with less than 6 months of alcohol abstinence can save lives. This multi- center study will examine the patient selection process for early liver transplantation, identify strategies most helpful to prevent return to alcohol use and to optimize long-term health after transplant.

PI_NAMEs: LUCEY, MICHAEL RONAN (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Abstinence;Acceleration;access disparities;Accounting;Acute;addiction;Address;Adult;alcohol abstinence;Alcohol consumption;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;American;Ancillary Study;Behavior Therapy;Behavioral;biobank;Blood;candidate selection;Cardiovascular system;Caring;Cessation of life;Chronic;Cirrhosis;Clinical;Clinical Pathways;clinical predictors;cohort;community-level factor;comorbidity;Consensus;Continuity of Patient Care;Data;data repository;deprivation;disorder control;drinking;effective therapy;effectiveness evaluation;efficacy evaluation;Eligibility Determination;end stage liver disease;Enrollment;Evaluation;Event;Exclusion;experience;Failure;Future;Geography;graft function;Graft Rejection;Health;health care disparity;Health Status;Heavy Drinking;Hepatitis;Heterogeneity;high risk;Hospital Costs;Hospitalization;implicit bias;improved;Incidence;Individual;Interview;Knowledge;Life;Link;Liver;Liver diseases;Liver Failure;liver transplantation;Longitudinal cohort;Malignant Neoplasms;Medical;medication-assisted treatment;meetings;Mental Health;Methods;Midwestern United States;Modeling;mortality;mortality risk;Multicenter Studies;multilevel analysis;Natural History;Neighborhoods;Organ;organ allocation;Outcome;Patient Outcomes Assessments;Patient Selection;Patient-Focused Outcomes;Patients;Peripheral Blood Mononuclear Cell;Pharmacotherapy;Phenotype;Policies;prevent;Procedures;Process;Prognosis;Prognostic Factor;prolonged abstinence;prospective;psychosocial;Psychosocial Factor;Quality of life;radiological imaging;recruit;Risk;risk prediction;Safety;Sample Size;Selection Criteria;Site;sobriety;social health determinants;Social support;sociodemographics;Sodium Chloride;Source;Standardization;Substance Use Disorder;Systematic Bias;Tissue Donors;Tissues;transplant centers;Transplant Recipients;Transplantation;Transplanted Liver Complication;treatment program;Urine;Waiting Lists

PROJECT_TITLE: 3/4-American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: TUCSON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Theoretical and computational methods are now central to understanding basic mechanisms in biological systems. Promoting vibrations in enzymes were discovered by our computational methods. We now propose to expand these studies to all timescales appropriate to enzyme turnover and eventually to the field of artificial enzyme design.

PI_NAMEs: SCHWARTZ, STEVEN D (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TITLE: Protein dynamics from femtoseconds to milliseconds as crafted by natural and laboratory evolution: towards enzyme design

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Despite robust CD8 T cell reinvigoration by PD-1 blockade in the majority of melanoma patients, only a minority gain clinical responses. The goal of this proposal is to understand why robust reinvigoration of exhausted CD8 T cells by αPD-1 does not necessarily translate to clinical efficacy. We test whether loss of progenitor exhausted CD8 T cells after PD-1 blockade is associated with clinical failure, and whether a tumor- related niche is important in maintaining the pool of progenitor exhausted CD8 T cells.

PI_NAMEs: HUANG, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Acceleration;Address;Aftercare;anti-PD-1;anti-PD1 therapy;anti-tumor immune response;Antigens;Biometry;Blood;Cancer Patient;CD8-Positive T-Lymphocytes;cell type;Cells;Chronic;Clinical;clinical efficacy;Clinical Trials;clinically relevant;Clone Cells;Collection;combinatorial;cytokine;Data;Dendritic Cells;Development;Dose;Equilibrium;exhaust;experience;Failure;Frequencies;Genetic Transcription;Goals;Homeostasis;Human;human stem cells;immune checkpoint blockade;Immunofluorescence Immunologic;Immunology;Impairment;improved;Inflammation;Knowledge;lymphoid structures;Malignant Neoplasms;Melanoma;Melanoma patient;Melanoma Tumor;Minority;Modeling;Neoadjuvant Therapy;neoplastic cell;novel therapeutics;Outcome;Participant;Pathology;Patients;PD-1 blockade;Population;Positioning Attribute;preclinical study;preservation;prevent;Production;progenitor;programs;Proliferating;Research Personnel;Resolution;response;RNA;Role;self-renewal;Signal Transduction;stem cell differentiation;stem cell niche;stem cells;Stress;Structure;Study Subject;Supporting Cell;T cell differentiation;T cell infiltration;T cell receptor repertoire sequencing;T cell response;T-Cell Depletion;T-Lymphocyte;T-Lymphocyte Subsets;tertiary lymphoid organ;Testing;Time;transcriptomics;Translating;tumor;tumor eradication;Viral Cancer;Virus Diseases

PROJECT_TITLE: Role of progenitor exhausted CD8 T cells and the progenitor niche in anti-PD1 efficacy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: Los Angeles

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative This project will expand the currently limited utility of otoacoustic emissions (OAE) in the audiology clinic. It will refine, test, and validate an OAE profile that includes the rapid and simultaneous recording of two types of emissions for the detection, differential diagnosis, and monitoring of hearing loss. Translating this profile into the hearing clinic will facilitate targeted and personalized intervention in individuals with hearing impairment.

PI_NAMEs: ABDALA, CAROLINA  (contact);SHERA, CHRISTOPHER A

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Abbreviations;Audiology;Auditory;Calibration;Clinic;Clinical;Cochlea;cohort;Computer software;Decision Theory;Detection;detection test;Diagnosis;Diagnostic;Diagnostic Specificity;Diagnostic tests;Differential Diagnosis;Etiology;External auditory canal;Factor Analysis;Frequencies;Functional disorder;Goals;Health;Hearing;hearing impairment;Hearing Tests;improved;Individual;innovation;Intervention;Joints;Laboratories;Learning;Least-Squares Analysis;Measurement;Measures;Methods;Modernization;Monitor;Morphologic artifacts;neural;normal hearing;otoacoustic emission;Outcome;Participant;Pathology;Performance;personalized intervention;preservation;pressure;Procedures;programs;Property;Protocols documentation;Research;research clinical testing;Resolution;Sensorineural Hearing Loss;Sensory;Source;Speed;Stimulus;System;Techniques;Test Result;Testing;Time;Translating;user friendly software;user-friendly

PROJECT_TITLE: Advanced Detection and Differential Diagnosis of Hearing Loss Using Otoacoustic Emissions


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE This research proposal is relevant to public health because it aims to maximize utility of a scare resource – organs donated for the purpose of life-saving transplantation. Our work aims to provide fundamental knowledge of mechanisms underlying rejection of the transplanted organs. Upon conclusion, this knowledge will enhance transplant allograft survival, reduce medical and financial ramifications associated with the need to treat rejection, and will improve transplant recipients' quality of life.

PI_NAMEs: TAMBUR, ANAT R. (contact)

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: Address;Adsorption;Affect;Algorithms;Alleles;allograft rejection;Allografting;allotransplant;Amino Acids;Antibodies;Antibody Formation;antibody-mediated rejection;Antigen Presentation Pathway;Applied Research;B-Lymphocytes;Categories;Cell Line;Cell surface;cell type;Cells;Characteristics;cohort;Color;comparative;Computer software;CRISPR/Cas technology;Development;donor-specific antibody;drug development;Endothelial Cells;Epitopes;Event;Exhibits;experience;experimental study;Frequencies;Generations;Genes;glomerular endothelium;glycosylation;Goals;graft dysfunction;Graft Rejection;Graft Survival;Histocompatibility Antigens;HLA Antigens;HLA-DP Antigens;HLA-DQ Antigens;human leukocyte antigen testing;human monoclonal antibodies;Immune;immune activation;Immune response;Immune Targeting;immunogenicity;Immunologics;Immunology;Immunosuppression;improved;in silico;Individual;innovation;knockout gene;Knowledge;Lead;Life;Ligation;Mass Spectrum Analysis;Measures;Mediating;Medical;Mission;Modeling;Molecular;Mutagenesis;National Institute of Allergy and Infectious Disease;novel;novel therapeutics;Organ;organ allocation;Organ failure;organ transplant rejection;Organ Transplantation;Outcome;pathogenic isoform;Pathogenicity;Pathway interactions;patient stratification;Patients;personalized medicine;Positioning Attribute;pressure;prevent;prognostication;Protein Isoforms;Proteins;Proteomics;Public Health;Quality of life;Reagent;Research;Research Proposals;Resources;response;Retinal Cone;Risk;risk stratification;Signal Pathway;Site-Directed Mutagenesis;Solid;standard of care;stem;symposium;T-Cell Receptor;T-Lymphocyte;Techniques;Technology;Testing;Time;tool;Transplant Recipients;Transplantation;Transplantation Immunology;Visualization;Work

PROJECT_TITLE: The immunogenicity and pathogenicity of HLA-DQ in solid organ transplantation


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE We show that the endoplasmic reticulum (ER) is structurally and functionally remodeled with age, and this remodeling requires an intact autophagy network, suggesting ER-phagy may drive these effects. Impairing ER tubulation suppresses age-onset mitochondrial fragmentation, which demonstrates ER morphology is a key determinant of organelle homeostasis in aging contexts. Indeed, longevity interventions such as dietary restriction preserve ER morphology, implicating ER dynamics as a novel driver of aging and establishing ER morphology as a new target for the prevention of age-related disease.

PI_NAMEs: DONAHUE, ERIC KF (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Adult;Advisory Committees;Age;Age of Onset;age related;age related changes;age related decline;age-related disease;Aging;aging mechanism;aging process;Automobile Driving;Autophagocytosis;Biological Aging;burden of chronic illness;Caenorhabditis elegans;Calcium;Caloric Restriction;Cell Physiology;Cellular biology;Child;Chronic;Communication;Complement;Cytoprotection;Cytoskeleton;Data;detection of nutrient;Developmental Biology;dietary restriction;disability;Disease;drivers of aging;Electron Microscopy;Endoplasmic Reticulum;Environment;Environmental Risk Factor;Equilibrium;Eukaryota;Event;experience;experimental study;extend lifespan;Family member;Feedback;Foundations;gain of function;Genes;Genetic;Genetic Engineering;hallmarks of aging;healthspan;healthy aging;Homeostasis;Human;Impairment;in vivo imaging;Intervention;knock-down;Laboratories;Laboratory Study;late life;Licensing;life span;Lipids;Longevity;loss of function;Mediating;Mediator;Membrane;Metabolism;Mitochondria;Molecular;Morbidity - disease rate;Morphology;mortality;mutant;Nature;Neurodegenerative Disorders;normal aging;novel;Nutrient;Organelles;Pathologic;Pathway interactions;Physiological;Physiology;Play;Population;preservation;Prevalence;prevent;Prevention;Process;professor;protective effect;Proteins;Proteome;proteostasis;Public Health;receptor;Recording of previous events;Recycling;Regulation;Reporter;Ribosomes;RNA Interference;Role;Rough endoplasmic reticulum;Shapes;Signal Transduction;Site;Smooth Endoplasmic Reticulum;Stress;Structure;Supervision;Techniques;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Time;tomography;Tubular formation;United States;Universities;Work

PROJECT_TITLE: Elucidating the role of ER remodeling in aging of C. elegans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Disability Research;Mental Health;Microbiome;Multiple Sclerosis;Neurodegenerative;Neurosciences;Nutrition;Obesity;Prevention;Rehabilitation;Sleep Research

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Cognitive and sensorimotor decline are common in multiple sclerosis (MS) and driven by cerebral gray matter atrophy. Building on our prior research on “reserve” against disability, we will investigate a novel dynamic model of reserve in the Reserve against Disability in Early MS (RADIEMS) cohort whereby candidate risk and protective factors modulate maintenance of cerebral gray matter to preserve function over time (MIND diet, obesity; Aim 1), or impact compensation for disease to maintain function (depression, sleep; Aim 2). This model will be tested and updated over time to understand mechanistic mediators of risk and protective factors, which will inform the development of interventions to preserve gray matter and improve functional outcomes.

PI_NAMEs: SUMOWSKI, JAMES FRANCIS (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: actigraphy;Atrophic;Berry;Biolectric Impedance;Biological Specimen Banks;Blood specimen;Body fat;Body mass index;Brain;Cerebrum;chronic neurologic disease;Cognitive;cognitive function;cohort;Cohort Studies;Compensation;Consent;Consumption;Data;Demyelinations;Depressed mood;depressive symptoms;Diagnosis;Diet;dietary;disability;Disease;disease diagnosis;emerging adult;Enrollment;Environment;Evaluation;Fishes;follow-up;functional decline;functional improvement;functional outcomes;Gait speed;Genes;gray matter;gut microbiota;Inflammatory;Lesion;Link;Literature;Longitudinal cohort study;Magnetic Resonance Imaging;Maintenance;Measurable;Measures;Mediating;Mediator;Memory;Mental Depression;metabolomics;microbiome sequencing;mind/body;Modeling;modifiable risk;Moods;Morbidity - disease rate;Multiple Sclerosis;multiple sclerosis patient;Nerve Degeneration;Nerve Regeneration;Neurons;neuropathology;novel;Nutrient;Nuts;Obesity;Outcome;Patients;Phenotype;Polysomnography;Positive Valence;preservation;protective factors;Proxy;psychologic;radiological imaging;REM Sleep;Reporting;Reproducibility;Research;resilience;Resolution;Resources;restorative treatment;reward processing;Risk Factors;Schedule;Sensorimotor functions;Sleep;Sleep Architecture;Sleep disturbances;Sleep Fragmentations;sleep quality;Speed;stool sample;Synapses;Testing;therapy development;Time;Update;Work

PROJECT_TITLE: Reserve against Disability in Early Multiple Sclerosis (RADIEMS) Longitudinal Cohort Study


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: BOSTON

ORG_NAME: BOSTON VA RESEARCH INSTITUTE, INC.

ORG_STATE: MA

PHR: This application proposes to examine whether rt-fMRI neurofeedback (rt-NFB), combined with mindful meditation (rt-NFB+M), and directed at the default mode network (DMN) in clinical high-risk individuals can reduce DMN connectivity (between posterior cingulate cortex (PCC) and the medial prefrontal cortex (MPFC)) and increase anticorrelations between MPFC (a hub of DMN) and dorsolateral prefrontal cortex (DLPFC; a hub of central executive network). In the R61, we will use rt-fMRI NFB+M to demonstrate brain target engagement: DMN connectivity reduction, MPFC-DLPC anti-correlation increase, post-rt-NFB+M, and assess GABA, glutamate, and other magnetic resonance spectroscopy (MRS) neurochemicals in the MPFC and DLPFC using resting state fMRI localization. In the R33, we will 1) replicate the R61 results in a larger sample; 2) examine dose-response over four sessions of rt-NFB +M; 3) test four sessions of NFB +M against four sessions of mindfulness only; 4) show cognitive and clinical improvement, post- rt-NFB +M; 5) relate the clinical and neuropsychological changes to brain changes at both cellular and network levels, post-rt-fMRI, in rt-NFB +M group and in meditation only group, co-localize resting state and neurochemical data to relate cellular and network-level processes, pre- and post-rt-NFB.

PI_NAMEs: LIN, ALEXANDER PETER;NIZNIKIEWICZ, MARGARET A (contact);WHITFIELD-GABRIELI, SUSAN

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Adopted;Attention;Attenuated;Auditory Hallucination;behavior measurement;Behavior Therapy;Behavioral;Benchmarking;Brain;brain abnormalities;brain dysfunction;Chronic Schizophrenia;cingulate cortex;Clinical;clinical high risk for psychosis;Cognition;Cognitive;cognitive change;comparison group;Control Groups;Crossover Design;Data;Development;Disease;Dose;effective therapy;efficacy evaluation;efficacy testing;experience;first episode schizophrenia;Functional Magnetic Resonance Imaging;Future;gamma-Aminobutyric Acid;Glutamates;Goals;Grant;high risk;high risk population;Impairment;improved;Individual;Intervention;Magnetic Resonance Spectroscopy;Measures;Medial;Meditation;Meta-Analysis;mindfulness;mindfulness meditation;Motor Cortex;Names;neural network;neurochemistry;Neurocognitive;neurofeedback;Neuropsychology;Neurotransmitters;Outcome;Patients;Pattern;pharmacologic;Phase;post intervention;Prefrontal Cortex;prevent;Process;prodromal psychosis;Psychoses;psychotic;psychotic symptoms;Randomized;reduce symptoms;Research;response;Rest;Risk;Sampling;Scanning;Schizophrenia;Short-Term Memory;Source;Superior temporal gyrus;Symptoms;Testing;Therapeutic Effect;Time;Work

PROJECT_TITLE: Real time neurofeedback, its neurotransmitter underpinnings, and therapeutic effects, in clinical high risk individuals


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Chronic Obstructive Pulmonary Disease;Clinical Research;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Accurate diagnosis is critical for patients hospitalized with acute dyspnea (shortness of breath), since depending on the cause (e.g., pneumonia versus congestive heart failure) treatment may vary. Artificial intelligence (AI) tools can be trained to analyze clinical and imaging data to determine the diagnosis but are susceptible to bias that results in poor generalization performance. Creating an environment where clinicians collaborate with AI to solve clinical challenges may realize the promise of AI in improving patient care.

PI_NAMEs: SJODING, MICHAEL WILLIAM (contact);WIENS, JENNA

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: accurate diagnosis;Acute;adversarial learning;Algorithms;Artificial Intelligence;artificial intelligence model;Caring;Chronic Obstructive Pulmonary Disease;Clinical;clinical decision support;Clinical Medicine;Clinical/Radiologic;clinically relevant;Collaborations;comorbidity;Complex;computer human interaction;Computer Vision Systems;Congestive Heart Failure;Controlled Environment;Data;Decision Making;Development;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Errors;diagnostic tool;Disadvantaged minority;Disease;Dyspnea;Elderly;Electronic Health Record;Emergency department visit;Environment;Etiology;Evaluation;Feedback;Female;health care settings;Healthcare;Heart failure;Hospitalization;Human;Hybrids;Image;improved;Institution;Intelligence;Knowledge;Laboratories;Learning;Machine Learning;male;Minority Groups;Modeling;multidisciplinary;multitask;Patient Care;patient population;patient subsets;Patient-Focused Outcomes;Patients;Performance;Physicians;Pneumonia;Positioning Attribute;Predisposition;Prevalence;Process;prospective;prospective test;Provider;Retinal blind spot;sex;Shortness of Breath;Symptoms;Techniques;Testing;tool;Training;training data;Trust;Uncertainty;Vision;Work

PROJECT_TITLE: Human-AI Collaborations to Improve Accuracy and Mitigate Bias in Acute Dyspnea Diagnosis

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Kidney Disease

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Variants in the Apolipoprotein 1 (APOL1) gene are major contributors to the increased burden of kidney disease in people of recent African ancestry; despite significant previous work investigating the pathogenesis of APOL1-associated kidney disease, basic questions regarding the APOL1 protein itself remain unanswered. In preliminary work, I have purified eukaryotically-expressed, recombinant APOL1 proteins and shown that they function as ion channels. I propose to determine the structure of the APOL1 protein and to determine how the high-risk variants functionally differ from the low-risk variant in vitro; these studies will improve our understanding of the mechanisms that cause APOL1-associated kidney disease and will help us develop new assays to identify drugs that specifically target APOL1.

PI_NAMEs: WAITZMAN, JOSHUA SAMUEL (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: African ancestry;African Trypanosomiasis;Age;Apolipoproteins;Biochemical Process;Biological Assay;Biophysical Process;biophysical properties;Biophysics;career;career development;Cations;Cell membrane;Characteristics;Chronic Kidney Failure;Complex;Cryoelectron Microscopy;Cytolysis;cytotoxic;Dedications;Development Plans;Disease;disease diagnosis;Disease Progression;Disputes;drug development;Electron Microscopy;Electrophysiology (science);End stage renal failure;Environment;Focal and Segmental Glomerulosclerosis;Funding;Future;Genes;Genetic;Genotype;Goals;Health Services Accessibility;high risk;improved;In Vitro;in vitro Assay;inhibitor;innovation;Ion Channel;Ions;Kidney;Kidney Diseases;Laboratories;Link;Lipoproteins;Liposomes;Membrane;Membrane Proteins;Mentors;Mentorship;Modeling;Molecular;monomer;Negative Staining;Not Hispanic or Latino;novel therapeutics;Outcome;pathogen;Pathogenesis;Pathologic;Patients;Persons;Pharmaceutical Preparations;Physicians;Physiology;podocyte;Positioning Attribute;prevent;Property;Proteins;Recombinants;reconstitution;Renal glomerular disease;Reporting;Research;Research Personnel;Resistance;Resolution;Resource Sharing;Risk;risk variant;Scientist;Serum;skills;social health determinants;structural biology;structural determinants;Structure;targeted treatment;Techniques;Testing;Toxic effect;Training;Trypanosoma;Trypanosoma brucei brucei;United States;Variant;Work

PROJECT_TITLE: Structure and mechanism of the kidney disease-causing protein APOL1

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK(M1)-1-D]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NATICK

ORG_NAME: INSTITUTE FOR FUTURE INTELLIGENCE, INC.

PHR: Artificial intelligence promises to accelerate the process and lower the cost of drug discovery. Integrating data science into high school chemistry and biology will prepare students with data and computing skills needed in this vital frontier of biomedical research while enhancing their learning of science and engineering expected by the Next Generation Science Standards. This project will combine culturally responsive teaching and inquiry‐based learning to promote equity and diversity.

PI_NAMEs: BULSECO, DYLAN ;CRIPPEN, KENT ;XIE, CHARLES  (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: academic standard;Acceleration;Address;Artificial Intelligence;Biology;Biomedical Research;Chemistry;citizen science;Collaborations;Complex;cost;Data;data integration;Data Science;design;Development;diversity and equity;Docking;Drug Costs;drug development;drug discovery;Drug Screening;Educational Curriculum;Educational process of instructing;Educational Technology;Educational workshop;Engineering;Equity;Ethics;falls;Feedback;Florida;frontier;Funding;Future;General Population;Hawaii;high school;improved;innovation;inquiry-based learning;Intelligence;interest;iterative design;Knowledge;Learning;learning community;Machine Learning;Maryland;medical schools;Methods;Mission;Molecular;National Center for Advancing Translational Sciences;Next Generation Science Standards;novel;novel therapeutics;Ohio;Procedures;Process;programs;Rare Diseases;Research;Research Personnel;Rhode Island;Schools;Science;skills;South Carolina;South Dakota;Students;teacher;Technology;Testing;United States National Institutes of Health;Universities;Visual

PROJECT_TITLE: Adventures in Drug Discovery: Integrating Data Science into the Science Curriculum

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Mental Health;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE Physical and emotional trauma are linked to numerous negative health effects, including a nearly three-fold increase in the odds of reporting chronic pain. Although social, psychological, and neurobiological factors have been linked to both the experience of trauma and pain, few studies have explored these potential mechanistic associations in the development of pain vulnerability following trauma. Understanding trauma-related prodromal factors may prove critical for developing models of post-traumatic pain vulnerability that can be used to identify patients at risk and tailor treatments to prevent the development of chronic pain following trauma.

PI_NAMEs: PIERCE, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Accident and Emergency department;Accidental Injury;Acute;Address;Affect;Affective;American;Area;Award;Characteristics;chronic pain;clinical pain;cohort;Computers;Data;Data Analyses;Data Set;Dedications;Development;Distress;Early identification;Emergency department visit;Emotional;emotional trauma;Emotions;Environment;Evaluation;experience;experimental study;falls;Funding;Future;Goals;Health;individualized medicine;Intentional injury;Knowledge;Leadership;lens;Link;Longitudinal Studies;Measures;Mediator;Mentored Research Scientist Development Award;Mentorship;Methodology;Methods;Michigan;Modeling;National Institute of Mental Health;Neurobiology;Outcome;Pain;pain chronification;pain outcome;pain sensitivity;pain symptom;Participant;Patient Self-Report;Patients;Perception;perspective taking;Phenotype;Post-Traumatic Stress Disorders;prevent;programs;psychologic;psychological symptom;Psychophysics;Reaction;Recording of previous events;Recovery;Reporting;Research;Research Design;Research Domain Criteria;Research Personnel;Research Proposals;response;Risk;Risk Factors;Role;Sensory;Series;sexual assault;skill acquisition;skills;social;Social Perception;Social Processes;Statistical Data Interpretation;Stimulus;Surveys;Survivors;Symptoms;Testing;Time;Training;Trauma;trauma exposure;trauma symptom;traumatic event;Universities;Vehicle crash;Vulnerable Populations

PROJECT_TITLE: Examining domains of trauma response and their link to chronic pain


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_DEPT: BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Epigenetic mechanisms (e.g. DNA methylation, histone post-translational modifications, histone variants) guide cell-fate determination, giving rise to different cell types in genetically homogenous multicellular organisms. Disruption of epigenetic signatures in asymmetrically dividing stem cells results in loss of stem cell homeostasis and is a common feature among diseases including infertility, muscular dystrophy, and many types of cancer. Thus, elucidating the mechanisms maintaining and regulating epigenetic memory through asymmetric cell division is essential for our understanding of normal development and the onset of diseased states.

PI_NAMEs: PALLADINO, JASON THOMAS (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: adult stem cell;age related;Aging;Biological;Biological Models;cancer cell;cancer type;Cancerous;cell age;cell behavior;Cell Cycle Progression;Cell Differentiation process;Cell division;Cell Lineage;Cell Nucleus;Cell Physiology;cell type;Cells;Chromatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Cues;Daughter;design;Detection;Deterioration;Development;Developmental Biology;Disease;Dissection;DNA;DNA Methylation;DNA Sequence;Drosophila genus;epigenetic memory;Epigenetic Process;epigenetic regulation;epigenomics;experimental study;Female;Fluorescent in Situ Hybridization;Ganglia;Gene Expression;genetic information;Genetic Variation;Genome;genomic locus;germline stem cells;Guide RNA;Health;Histones;Homeostasis;Human;in vivo;Infertility;Inheritance Patterns;Inherited;Intestines;Intrinsic factor;Knowledge;Label;Light;male;Malignant Neoplasms;Methodology;Methods;Mitosis;Mitotic;Molecular;Mothers;Mouse Embryonic Stem Cells;Muscular Dystrophies;nerve stem cell;neuroblast;Normal Cell;novel;Onset of illness;Organelles;Organism;Pattern;Phenotype;Play;Post-Translational Protein Processing;Process;Proliferating;Proteins;Research;Resolution;RNA;RNA library;Role;S phase;segregation;self-renewal;Spermatocytes;stem cell differentiation;stem cell homeostasis;stem cell model;stem cells;Structure;Technology;Testing;Time;tissue degeneration;Tissues;tool;Transgenic Organisms;Variant;Work

PROJECT_TITLE: Development and Application of a Novel Method to Study Histone Inheritance in Asymmetrically Dividing Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Despite the fact that T1D is one of the most studied organ-specific autoimmune diseases, the various strategies aimed at intervention, prevention, or reversal of this disease have failed to succeed. The proposed in vitro platform has the potential to bridge the current knowledge gap of the T1D immunopathology through the 3-D investigation of key cellular players and mechanisms of immune activation and progression, which will permit for improved targeted interventions that can delay disease progression or elevate the efficacy of cell replacement therapies.

PI_NAMEs: SAMOJLIK, MAGDALENA M (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: 3-Dimensional;Address;Adhesions;Affect;Animals;Anoikis;Antigens;Autoimmune Diseases;Beta Cell;Binding;Biocompatible Materials;Biological;Biological Assay;Biomimetics;blood glucose regulation;Blood Vessels;C-Peptide;CD8-Positive T-Lymphocytes;cell behavior;Cell Communication;cell injury;cell killing;Cell model;cell motility;Cell Physiology;cell replacement therapy;Cell surface;Cell Surface Receptors;Cells;Cellular Structures;chemokine;Clinical;Clinical Trials;Coculture Techniques;comorbidity;Complex;confocal imaging;Controlled Environment;cost;CRISPR/Cas technology;CXCL10 gene;cytokine;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;cytotoxicity;Data;diabetes pathogenesis;Dimensions;Disease;Disease Progression;Distress;Encapsulated;endocrine pancreas development;Engineering;Environmental Risk Factor;experimental study;Extracellular Matrix;Family suidae;Functional disorder;G6PC2 gene;Genes;Goals;Hemorrhage;histological specimens;Homing;Human;Hydrogels;Image;Image Analysis;Immune;immune activation;immunopathology;improved;In Situ;in situ imaging;In Vitro;in vitro Model;Induction of Apoptosis;innovation;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Intervention;Invaded;Investigation;islet;Islets of Langerhans;Knowledge;Macrophage;Mediating;Mediator;Membrane;Microfluidic Microchips;Microfluidics;microphysiology system;migration;mouse model;Mus;Neuropathy;Nutrient;Organ;Ovalbumin;Pancreas;Pathogenesis;Pathway interactions;Pattern;Peripheral;Pharmaceutical Preparations;prevent;Prevention;Protocols documentation;Risk;Role;screening;Signal Transduction;Source;spatial integration;Stimulus;System;T-Cell Receptor;T-Lymphocyte;Technology;Testing;Therapeutic;Therapeutic Intervention;therapy outcome;Time;tool;Translating;Work

PROJECT_TITLE: Engineering a dynamic three-dimensional in vitro platform for the investigation of human Type 1 Diabetes immunopathogenesis


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: DREXEL UNIVERSITY

PHR: Autistic persons experience health inequities throughout the life course, which result in preventable adverse outcomes disproportionally affecting minority and economically disadvantaged autistic individuals. The Public Health and Autism Science advancing Equitable Strategies across the life course (PHASES) Center uses an integrated public health research framework to characterize and mitigate health inequities in vulnerable subgroups on the autism spectrum.

PI_NAMEs: ROBINS, DIANA L (contact);SCHENDEL, DIANA

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: access disparities;Address;Adolescence;Adolescent;Adolescent and Young Adult;adolescent with autism spectrum disorder;Adult;adult with autism spectrum disorder;adverse outcome;Affect;Age;Aging;autism spectrum disorder;autistic;autistic children;Back;Basic Science;Biological Factors;Child;Childhood;Clinical Sciences;Cognitive;Collaborations;Communication;Communities;Community Networks;Complex;Data;data integration;Data Security;Detection;Deterioration;Diagnosis;Diagnostic Services;diverse data;early childhood;Early Diagnosis;economic disparity;Economically Deprived Population;Electronic Health Record;Ensure;Environmental Risk Factor;Equity;ethnic diversity;evidence base;experience;Feeds;Future;Goals;Health;health care delivery;health care service;health determinants;health inequalities;health service use;Health Services;Healthcare;improved;Individual;individuals with autism spectrum disorder;Inequity;innovation;Knowledge;Life;Life Cycle Stages;life span;Link;Medicaid;Medicare;middle age;minimally verbal;Minority;older adult;Outcome;outreach;Personal Satisfaction;Population;Population Heterogeneity;Populations at Risk;pressure;Prevalence;Prevention;Preventive;primary care visit;programs;Public Health;public health research;Quality of life;racial diversity;Research;Research Project Grants;Risk;Science;screening;Security;service delivery;social factors;Source;Strategic Planning;Structure;Subgroup;synergism;System;Testing;Toddler;tool;transition to adulthood;Underrepresented Minority;United States National Institutes of Health;Vulnerable Populations;young adult


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Heart Disease;Pediatric;Physical Activity;Prevention

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE / RELEVANCE TO PUBLIC HEALTH Cardiovascular disease is the nation’s leading cause of death. This project will develop evidence to bridge the knowledge gaps identified by the 2018 Physical Activity Guidelines for Americans by describing independent effects of sedentary behavior and the potential offsetting effects of physical activity during adolescence and young adulthood on the prevention of later-life cardiovascular disease. The results are aimed at informing the next version of the national physical activity guidelines specifically for adolescents and young adults, which can be promoted using targeted implementation science and modeling approaches, thereby contributing to the National Heart, Lung, and Blood Institute’s (NHLBI) strategic vision of reducing heart disease nationwide.

PI_NAMEs: NAGATA, JASON M (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Accounting;Adolescence;Adolescent;Adolescent and Young Adult;Adult;Age;age group;age related;American;Area;Articulation;Behavior;Biometry;Brain;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;career;career development;Cause of Death;Cessation of life;Clinical Trials;cognitive development;cohort;Coronary Artery Risk Development in Young Adults Study;COVID-19 pandemic;Data;Data Science;Development;Development Plans;Diabetes Mellitus;Dose;Early Intervention;Epidemiologist;Event;evidence base;experience;Exposure to;Future;Grant;Growth and Development function;Guidelines;Health;Health Benefit;Heart Diseases;Human;Hyperlipidemia;Hypertension;implementation science;Incidence;Intervention;Knowledge;late life;Life;Link;longitudinal analysis;Longitudinal cohort;Longitudinal Studies;markov model;Measurement;Medicine;meetings;Mentors;Mentorship;Methods;Modeling;Modification;mortality;Myocardial Infarction;National Heart, Lung, and Blood Institute;National Longitudinal Survey of Adolescent to Adult Health;Pattern;Physical activity;physical inactivity;Physicians;Population;Premature Mortality;prevent;Prevention;Public Health;Recommendation;Research Priority;Resource Allocation;Rest;Risk;Risk Factors;sedentary;sedentary lifestyle;Services;skills;social media;Specific qualifier value;Strategic vision;Stroke;symposium;Testing;Text Messaging;Time;Training;tv watching;United States;United States Dept. of Health and Human Services;video chat;Video Games;Visual impairment;young adult

PROJECT_TITLE: Informing national guidelines on adolescent and young adult physical activity and sedentary behavior to prevent cardiovascular disease

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Autism;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health

PI_NAMEs: ROBINS, DIANA L (contact)

PROJECT_TERMS: 3-Dimensional;Accounting;Address;Advisory Committees;Archives;Authorship;autism spectrum disorder;cohesion;Collaborations;Committee Members;Communication;Communities;Communities That Care;community based participatory research;community engagement;community partners;Data;design;Doctor of Philosophy;Ensure;Equity;Evaluation;experience;Fertilization;Fostering;Goals;Grant;Guidelines;Human Resources;human subject;Infrastructure;insight;Institutional Review Boards;Leadership;Life Cycle Stages;Manuscripts;meetings;member;Methodology;mid-career faculty;Mission;Monitor;operation;outreach;Pathway interactions;Policies;Principal Investigator;Procedures;Process;programs;Progress Reports;Public Health;Publications;Recording of previous events;Reporting;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Science;Scientific Inquiry;senior faculty;stakeholder perspectives;Strategic Planning;Structure;success;Sum;symposium;synergism;Training;transmission process;United States National Institutes of Health;Vision

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-T]


NIH_SPENDING_CATS: Aging;Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

PI_NAMEs: PLUMB, JENNIFER  (contact)

PROJECT_TERMS: Address;Adolescent and Young Adult;Adult;autism spectrum disorder;Childhood;college;Communication;Communities;community based participatory research;community engagement;Country;Coupled;Data Collection;design;Diagnosis;Discipline of Nursing;Dissemination and Implementation;Economically Deprived Population;Educational Curriculum;Epidemiology;Equity;evidence base;experience;Family;graduate student;Health;health care delivery;health determinants;health inequalities;Health Occupations;Healthcare;Impaired cognition;implementation strategy;improved;individuals with autism spectrum disorder;Inequity;Infrastructure;innovation;lectures;Life Cycle Stages;life span;Medicine;member;Mental Health;Methodology;Methods;minimally verbal;Modeling;Newsletter;next generation;older adult;Outcome;outreach;Pediatric Hospitals;Pennsylvania;Philadelphia;Policies;Positioning Attribute;Postdoctoral Fellow;Process;Psychology;Public Health;public health research;Public Health Schools;Reporting;Research;Research Design;Research Personnel;Resources;Science;Scientist;Services;social media;Sociology;Strategic Planning;Subgroup;Toddler;Training;training opportunity;Translations;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;Work;young adult

PROJECT_TITLE: Dissemination and Outreach Core


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PUBLIC HEALTH RELEVANCE: The proposed research is relevant to public health because elucidation of the fundamental mechanisms in genomic imprinting will lead to better understanding of the causes and pathogenesis of infertility, molar pregnancy, imprinting diseases, and cancer. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to developing fundamental knowledge for ultimately protecting and improving health.

PI_NAMEs: CHEN, TAIPING  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Ablation;Adult;Alleles;Arginine;arginine methyltransferase;Classification;Development;Disease;DNA Methylation;DNA Modification Methylases;DNMT3a;Embryonic Development;Enzymes;Epigenetic Process;Exhibits;experimental study;Female;Fertilization;Gametogenesis;Gene Expression;Gene Order;Genes;Genetic study;Genome;genome-wide;Genomic DNA;Genomic Imprinting;Genomic Segment;Germ Cells;Germ Lines;H19 gene;Health;Hydatidiform Mole;Impairment;imprint;improved;Infertility;Inherited;innovation;insight;Knowledge;Laboratories;Maintenance;male;Malignant Neoplasms;Mediating;Methylation;Mission;Molecular;Mouse Embryonic Stem Cells;Mus;mutant;N-terminal;novel;Occupations;offspring;paternal imprint;Pathogenesis;Pattern;Play;Public Health;public health relevance;Regulation;Repression;Research;Role;sexual dimorphism;Signal Transduction;Specificity;sperm cell;Spermatocytes;Testing;Tissues;United States National Institutes of Health;Work

PROJECT_TITLE: Role of PRMT7 in Genomic Imprinting

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Prevention

ORG_DEPT: PSYCHOLOGY

ORG_NAME: HUNTER COLLEGE

PHR: PROJECT NARRATIVE Despite decades of research on behavioral aspects of cancer prevention and control (BCPC), many individuals continue to engage in risky behaviors, and many continue to bear the considerable psychological burdens associated with cancer risk, diagnosis, treatment and survival. BCPC research is the key to moving this critical field forward, but there remains a significant shortage of talented BCPC researchers. The proposed program aims to have a significant impact on the field by giving outstanding undergraduate students immersive exposure to rigorous BCPC summer research and career development experiences, yielding a pool of highly advanced candidates uniquely prepared for graduate training and impactful employment in the future BCPC workforce.

PI_NAMEs: ERBLICH, JOEL  (contact);FORD, JENNIFER S

PROGRAM_OFFICER_NAME: ZAHIR, NASTARAN

PROJECT_TERMS: Acceleration;Address;Affect;Alcohol consumption;Area;Awareness;Behavioral;Cancer Control;Cancer Control Research;cancer health disparity;cancer prevention;cancer risk;cancer therapy;career;career development;Career Mobility;Cities;cohort;Collaborations;college;Communication;Competence;Dedications;Development;Diagnosis;Diet;Education;effectiveness evaluation;Employment;Evaluation;Exercise;experience;Exposure to;First Generation College Students;Funding;Future;Generations;Graduate Education;Heightened Cancer Risk;Individual;Infrastructure;Knowledge;laboratory experience;Malignant Neoplasms;medical schools;meetings;member;Mentors;Mentorship;Methodology;Minority-Serving Institution;Modeling;multidisciplinary;New York;New York City;next generation;Oncology;Online Systems;Outcome;Population Heterogeneity;Process;Productivity;Program Effectiveness;programs;psychologic;Quality of life;recruit;relapse risk;Research;research and development;Research Personnel;Research Training;Resources;responsible research conduct;Risk Behaviors;satisfaction;scaffold;Scientist;skills;student training;Students;summer research;Sun Exposure;symposium;System;Talents;Time;Tobacco use;Training;Training Activity;Training Programs;treatment response;undergraduate research;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;university student;urban minority;verbal;Work;Writing

PROJECT_TITLE: STANDOUT in Behavioral Cancer Prevention and Control Research: Summer Training Accelerating and Nurturing the Development of Outstanding Undergraduate Trainees

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Autism;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

PI_NAMEs: SHEA, LINDSAY LAWER (contact)

PROJECT_TERMS: Address;Adolescent;Age;Area;Autism Diagnosis;autism spectrum disorder;Caring;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;Clinical;Code;cohesion;Collaborations;Communication;Communities;Complex;complex data;Data;data acquisition;Data Analyses;Data Collection;Data Linkages;data management;Data Security;Data Set;Data Sources;data structure;data visualization;data warehouse;design;Development;Doctor of Philosophy;Electronic Health Record;Ensure;Equity;experience;Faculty;Goals;Health;health data;health inequalities;Health Policy;Human Resources;improved;indexing;Individual;Information Systems;Infrastructure;innovation;Institution;Joints;Knowledge;large scale data;Leadership;Life Cycle Stages;Managed Care;marginalized population;Medicare claim;Medicare/Medicaid;Mental Health;mortality;novel;older adult;operation;Outcome;outreach;Patients;pediatrician;Policies;Population;Population Heterogeneity;Process;programs;Provider;Public Health;Research;Research Project Grants;Resources;Risk;Safety;Science;screening;service utilization;Services;Shapes;Site;Source;Staff Development;Standardization;Statistical Data Interpretation;Strategic Planning;Structure;success;synergism;System;Toddler;tool;United States Centers for Medicare and Medicaid Services;United States Health Resources and Services Administration;United States National Institutes of Health;Universities;young adult

PROJECT_TITLE: Data Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hypertension;Neurosciences;Precision Medicine;Prevention;Rehabilitation;Stroke

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative Project Narrative/Public Health Relevance: Stroke is the leading cause of disability in the United States, and this research proposal addresses the NIH mission to reduce the burden of neurological disorders and enhance the quality of life of people with disability. Current stroke treatments are primarily aimed at treating blockage of blood vessels but are only partially effective, leaving a great need for additional adjunctive therapies. Effective blood pressure management tailored to individual patients, with the aim of maintaining optimal brain blood flow, may prevent additional brain injury, and is an important first-step towards personalized medicine in stroke.

PI_NAMEs: PETERSEN, NILS H. (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acute;acute stroke;Address;Algorithms;Area;Award;biomedical informatics;Blood Pressure;blood pressure control;blood pressure intervention;blood pressure reduction;Blood Vessels;Brain Injuries;career;Caring;cerebral autoregulation;Cerebral Edema;cerebral hemodynamics;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Clinical;clinical center;clinical investigation;Clinical Management;Clinical Trials;Clinical Trials Design;Collaborations;Complex;computerized data processing;Data;Data Analyses;Data Science;Dedications;diagnostic strategy;disability;Disabled Persons;Early Intervention;effectiveness evaluation;endovascular thrombectomy;Enrollment;Environment;feasibility testing;Fostering;Frequencies;functional outcomes;Funding;Goals;Guidelines;hemodynamics;Hemorrhage;Homeostasis;Hospitals;Hour;Human;hypoperfusion;improved;improved outcome;individual patient;individualized medicine;Infarction;Informatics;insight;inter-institutional;Intervention;Ischemic Stroke;K-Series Research Career Programs;Knowledge;Machine Learning;Measurement;Medical Informatics;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;Mission;modifiable risk;Monitor;Morbidity - disease rate;Near-Infrared Spectroscopy;Nervous System Disorder;Neurologic;Neurologist;neuroprotection;Observational Study;Outcome;Patient Care;Patients;personalized medicine;pharmacologic;Phase;Physician Executives;Physicians;Physiological;Physiology;Positioning Attribute;post stroke;preservation;pressure;prevent;professor;Protocols documentation;public health relevance;Quality of life;radiological imaging;randomized trial;Recommendation;Recovery;Reperfusion Injury;Reperfusion Therapy;Research;research clinical testing;Research Personnel;Research Proposals;Resources;Risk;Risk Factors;Scientist;Secondary to;signal processing;skill acquisition;standard of care;Step Tests;Stroke;stroke therapy;Technology;Testing;therapeutic effectiveness;Time;Training;treatment strategy;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: Precision blood pressure management after endovascular stroke therapy based on real-time autoregulation measurements


PHR: Narrative The research we propose will identify for the first time key characteristics of donor-specific B cell responses in kidney transplant recipients to determine what properties associate with and potentially contribute to stable graft function, as opposed to rejection. The research might reveal novel approaches to assessing risk, new targets for biological intervention. The research might also inspire rational approaches to modifying B cell responses in transplant recipients in a personalized manner with the goal of promoting protective responses and antagonizing pathogenic ones.

PI_NAMEs: CASCALHO, MARILIA ISABEL (contact);PLATT, JEFFREY L

PROJECT_TERMS: Affinity;Allogenic;Antibodies;antibody-mediated rejection;Antigens;Avidity;B cell repertoire;B-Lymphocytes;Binding;Biological;Blood;Cells;Characteristics;Chronic;Clone Cells;Complement Activation;cytokine;Diagnostic;Donor person;donor-specific antibody;Evolution;Exhibits;Frequencies;Glycocalyx;Goals;graft function;Graft Survival;Immune;Immunoglobulin Genes;Immunoglobulin Somatic Hypermutation;Immunoglobulins;immunoregulation;indexing;interest;Intervention;Investigation;isoimmunity;Kidney Transplantation;Light;longitudinal analysis;Mediating;Methods;Mutation;novel strategies;Outcome;Pathogenicity;personalized therapeutic;Phenotype;Production;Property;Prospective Studies;Recombinants;Recovery;Research;response;Risk;Risk Assessment;sample fixation;Serum;Signal Transduction;single cell sequencing;Somatic Mutation;Specificity;T-Lymphocyte;Testing;therapeutic development;Time;Tissue Grafts;transcriptome sequencing;Transplant Recipients;Transplantation

PROJECT_TITLE: Donor-specific B cells in Transplantation

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Academic Medical Centers;Academy;access disparities;Address;Age;Age disparity;American;Asian;Attitude;autism spectrum disorder;autistic children;Belief;Black race;checkup examination;Child;Child Care;Childhood;Collection;Communities;Detection;Diagnosis;disadvantaged background;disparity reduction;Early Diagnosis;Early Intervention;economic disparity;Effectiveness;Electronic Health Record;Eligibility Determination;Enrollment;Equity;ethnic diversity;ethnic minority;Ethnic Origin;Evaluation;Evidence based practice;Future;future implementation;Health;health care delivery;health determinants;health inequalities;Health Personnel;Health Services;Healthcare Systems;Hispanic;implementation fidelity;implementation trial;improved;improved outcome;individuals with autism spectrum disorder;Inequity;Insurance Coverage;interest;Interview;Investigation;Knowledge;Life Cycle Stages;life span;Literature;Location;Machine Learning;machine learning algorithm;Methods;multi-racial;Not Hispanic or Latino;Outcome;outcome prediction;pediatrician;Pediatrics;peer;practice factors;practice setting;Predictive Factor;Primary Care;primary care practice;primary outcome;Provider;provider factors;Public Health;Race;racial diversity;racial minority;random forest;Randomized, Controlled Trials;Readiness;Recommendation;Research Design;Resources;Risk;Rural;Sample Size;Sampling;scale up;Science;screening;sex;sociodemographics;Socioeconomic Status;socioeconomics;Structure;suburb;supervised learning;Surveys;Testing;Time;Toddler;trial design;Underrepresented Minority;Visit;Well Child Visits

PROJECT_TITLE: Strategies to Facilitate Early Detection of Autism in Primary Care


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

PHR: Project Narrative The Training Program in Cancer Epidemiology, Prevention, and Control prepares pre- and postdoctoral trainees to be the next generation of population-based researchers who will set and address the nation's cancer research agenda with the goal of reducing cancer incidence, morbidity, recurrence, and mortality, and the disparities in cancer.

PI_NAMEs: JOSHU, CORINNE E.;MORAN, MEGHAN BRIDGID;PLATZ, ELIZABETH A. (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: Institutional Research Cancer Epidemiology Fellowship


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SCHENDEL, DIANA  (contact)

PROJECT_TERMS: Accidental Injury;Address;Adolescence;Adolescent;Adolescent and Young Adult;adolescent with autism spectrum disorder;Adult;Advocate;Age;age group;age related;aged;Aging;Ambulatory Care;autism spectrum disorder;autistic;Behavioral;behavioral health;Biological;Brain;burden of illness;Categories;Cessation of life;Child;Childhood;Communities;community engagement;contextual factors;Data;Development;Diagnosis;disability-adjusted life years;Disparity;Emergency Care;Emergency medical service;Emergency Situation;Enrollment;Equity;ethnic disparity;ethnic diversity;Ethnic Origin;Ethnic Population;Event;experience;follow-up;Future;Goals;Health;health inequalities;health knowledge;Health Services;Health system;Healthcare;Heterogeneity;implementation efforts;improved;Individual;individuals with autism spectrum disorder;innovation;Inpatients;Intervention;Knowledge;Life;Life Cycle Stages;Literature;Medicaid;Methods;Modeling;mortality;multimodality;novel;Outcome;Outpatients;Participant;Pathway interactions;Pattern;Persons;Pharmaceutical Preparations;Phase;Population;Population Heterogeneity;premature;pressure;Prevalence;prevent;Process;Public Health;public health research;Quality of life;Race;racial disparity;racial diversity;racial population;Recording of previous events;Research;Risk;Sampling Studies;Science;service delivery;service utilization;Services;sex;Social Change;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Status;socioeconomics;study population;Subgroup;Suicide;System;Vulnerable Populations;Work;World Health;years lived with disability;years of life lost;young adult

PROJECT_TITLE: Leveraging Trajectories of Health and Services Use to Improve the Health of Autistic Young Persons


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Dystonia;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Rare Diseases;Rehabilitation

ORG_DEPT: PATHOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Deep brain stimulation (DBS) is an effective intervention for treating a wide range of brain diseases; DBS is successful when traditional medicines fail and when patients become drug resistant. Even though current DBS methods have reduced the burden of disease symptoms, there is a large number of people in the US, and worldwide, that do not respond to the treatment. Therefore, it is important to develop additional DBS strategies, such as the one we tested in this project, to benefit more patients.

PI_NAMEs: SILLITOE, ROY VINCENT (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Address;Affect;Anatomy;Animal Behavior;Animal Model;Ataxia;Behavior;behavioral outcome;behavioral response;Biological;Biological Markers;Brain;Brain Diseases;Brain region;brain repair;burden of illness;Cell Nucleus;Cerebellar Cortex;Cerebellar Diseases;Cerebellar Nuclei;Cerebellum;Cerebral Palsy;Chronic;Code;cognitive function;Deep Brain Stimulation;Defect;Dentate nucleus;design;Development;Disease;disease model;Disease Outcome;Drug resistance;drug resistance development;Dystonia;Eating Disorders;effective intervention;effective therapy;Electrophysiology (science);Epilepsy;Equilibrium;experimental study;feasibility testing;Feedback;Fiber;Foundations;Frequencies;Functional disorder;Genetic;Genetic Models;Gilles de la Tourette syndrome;Globus Pallidus;Goals;Healthcare;human disease;human model;improved;in vivo;insight;Learning;Link;Location;Locomotion;Measures;Mental disorders;Methods;Molecular;Motor;motor behavior;motor deficit;motor disorder;mouse genetics;mouse model;Movement;Mus;Muscle;Nervous System Disorder;neural;neural circuit;neuronal patterning;Neurons;Neurophysiology - biologic function;neuropsychiatric disorder;neurosurgery;neurotransmission;Obsessive-Compulsive Disorder;optogenetics;Output;Pain;Parkinson Disease;Patients;Pattern;Persons;Pharmaceutical Preparations;Population;Posture;Predisposition;Proxy;Purkinje Cells;Quality of life;Recovery of Function;Research;Resolution;Rest;Role;Schizophrenia;Signal Transduction;Site;spasticity;Spinal Cord;stroke therapy;Structure;Structure of subthalamic nucleus;Symptoms;Synapses;System;Testing;Thalamic structure;Therapeutic;Traditional Medicine;Tremor;Work

PROJECT_TITLE: Cerebellar Deep Brain Stimulation

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Autism;Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

PROJECT_TERMS: Acute;adolescent with autism spectrum disorder;Adult;adult with autism spectrum disorder;advanced system;Adverse effects;Age;aged;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;autism spectrum disorder;autistic;care costs;care outcomes;care systems;Caregivers;Caring;Characteristics;Child;Chronic;Clinical;cohort;Communities;community advisory board;comparative;comparison group;cost;cost estimate;Data;Data Linkages;Data Set;Dementia;Diagnosis;early onset;Economically Deprived Population;Emergency Care;end of life;Epilepsy;Equity;Ethnic Population;experience;Family;Funding;General Population;Goals;Health;Health Care Costs;health difference;health inequalities;Health Services Accessibility;Healthcare;high risk;Hospitalization;human old age (65+);Hypertension;improved;Individual;individuals with autism spectrum disorder;Inequity;innovation;insight;Insurance Carriers;International;Interview;Investments;Life Cycle Stages;life span;life time cost;Link;Lived experience;Machine Learning;Medicaid;Medical;Medical Care Costs;Medicare/Medicaid;meetings;Mental Depression;Mental Health;Mental Health Services;Methods;middle age;mortality;Neurologic;older adult;Outcome;Parkinson Disease;Parkinsonian Disorders;Participant;patient oriented;peer;Policies;Prevalence;prevent;Preventive screening;Public Health;Quality of life;racial diversity;racial population;Records;recruit;Research;Resources;Risk;Risk Assessment;Sample Size;Sampling;Science;service delivery;Services;Source;Stroke;suicide rate;Surveys;System;young adult;Youth

PROJECT_TITLE: Advancing the System of Care for Autistic Older Adults


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Lead Poisoning;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative This proposal aims to define the epigenetic mechanism contributing to altered synaptic plasticity arising from developmental lead (Pb) exposure and when coupled with a genetic risk factor of Alzheimer's disease, SORL1, to assess gene-by-environment (GxE) interaction. We will reveal molecular and cellular features that drive the acceleration of Alzheimer's disease onset and progression induced by Pb neurotoxicity via a combination of state-of-the-art sequencing and imaging tools.

PI_NAMEs: FREEMAN, JENNIFER L. (contact);YUAN, CHONGLI

PROGRAM_OFFICER_NAME: DHRUV, NEEL TUSHAR

PROJECT_TERMS: abeta accumulation;Acceleration;Address;Adopted;Affect;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;Amyloid Fibrils;Animal Model;antagonist;Attenuated;Automobile Driving;Behavioral;Biological;bisulfite sequencing;Calcium;Cells;Central Nervous System;Coupled;CRISPR interference;Data;Data Set;design;Development;disease phenotype;Disease Progression;DNA Methylation;Dose;Early Onset Alzheimer Disease;Embryo;Endosomes;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Etiology;Event;Exhibits;experimental group;experimental study;Exposure to;gene environment interaction;Gene Expression Regulation;Genes;Genetic;genetic risk factor;Genetic Transcription;Glutamate Receptor;Glutamates;Goals;Heavy Metals;Heritability;Heterogeneity;Human;Imaging Device;Impairment;Induced pluripotent stem cell derived human neuron;Knowledge;Late Onset Alzheimer Disease;Lead;lead exposure;Learning;Life;Literature;Long-Term Potentiation;Lysosomes;Mediating;Memory;Mental Depression;Methylation;Mining;Modeling;Molecular;Morphology;Mutation;Nerve Degeneration;nerve stem cell;Neurologic;Neurons;neurotoxicity;novel;Onset of illness;Pathway interactions;Phenotype;Play;postsynaptic;Predisposition;progression risk;protein aggregation;Receptor Gene;receptor recycling;Research;Resolution;Risk;Risk Factors;RNA;RNA Interference;Role;Route;Series;Spatial Distribution;Structure;Study models;success;superresolution imaging;Symptoms;Synapses;Synaptic Cleft;synaptic function;Synaptic plasticity;tau aggregation;Testing;Time;time use;tool;trafficking;transcriptome;transcriptome sequencing;transcriptomics;transmission process;Vertebral column;Zebrafish

PROJECT_TITLE: Mechanisms of gene-environment interaction in developmental lead exposure leading to Alzheimer's disease phenotypes

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Neurosciences;Nutrition;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative IDH mutant gliomas are slowly progressive primary brain tumors that are diagnosed in young and middle- adulthood and lead to untimely death despite aggressive treatment with surgery, radiation and chemotherapy. We propose to explore how metabolic differences between tumor and healthy tissue can be exploited for use as a treatment strategy in clinically relevant tumor models of IDH mutant glioma. The overarching goal of this research is to determine the effectiveness and mechanism of Sirt1 activation, by small molecules or diet, in preclinical models of IDH mutant glioma to provide a rationale for translating this strategy into human clinical trials.

PI_NAMEs: MILLER, JULIE JOANN (contact)

PROJECT_TERMS: Adult;Adult Glioma;Affect;aggressive therapy;anti-cancer research;Award;Biology;Brain Neoplasms;Caloric Restriction;cancer cell;cancer therapy;career development;CDK4 gene;CDKN2A gene;Cell Cycle;Cell Cycle Inhibition;Cell Physiology;Cell Proliferation;Cells;Cessation of life;Characteristics;chemotherapy;Chemotherapy and/or radiation;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Coenzymes;Collaborations;Communities;Cyclin-Dependent Kinase Inhibitor 2A;cytotoxicity;Data;Deacetylase;Dementia;design;Diabetes Mellitus;Diet;Diet Modification;Dietary Intervention;dietary restriction;Disease;DNA Damage;Effectiveness;effectiveness evaluation;efficacy evaluation;Environment;Enzymes;Epigenetic Process;epigenomics;Exhibits;experience;Frequencies;Funding;Future;gain of function mutation;General Hospitals;Generations;Genes;Genetic;Genetic Transcription;genotoxicity;Glioblastoma;Glioma;Glucose;Goals;Grant;Growth;Hallmark Cell;Heterogeneity;Human;Implant;In Vitro;in vitro Model;in vivo;inhibitor;Institution;instructor;interest;Intermittent fasting;Investigation;Isocitrate Dehydrogenase;Longevity;Malignant - descriptor;Malignant Neoplasms;Massachusetts;medical schools;Mentors;Metabolic;Metabolism;metabolomics;Methods;middle age;Modeling;mouse model;mutant;Mutation;neoplastic cell;neuro-oncology;Neurologic;Neurology;Neurons;novel therapeutics;Nutrient availability;Operative Surgical Procedures;overexpression;Pathway interactions;Patients;Phenotype;Physicians;Population;Positioning Attribute;Pre-Clinical Model;premature;prevent;Primary Brain Neoplasms;Process;Production;Prognosis;programs;protective effect;Publishing;Radiation;Recurrence;Recurrent disease;Reporting;Research;Research Personnel;Resistance;response;Scientist;side effect;Signal Transduction;SIRT1 gene;small molecule;Techniques;Testing;Time;Tissues;Training;trait;transcriptome sequencing;transcriptomics;Translating;translational research program;treatment strategy;tumor;tumor diagnosis;tumor eradication;tumor growth;tumor metabolism;Tumor Promotion;Up-Regulation;Work;Xenograft procedure;young adult

PROJECT_TITLE: Investigation of Sirt1 activation to target IDH mutant glioma

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEWARK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS THE STATE UNIV OF NJ NEWARK

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because African Americans, particularly those with lower income, have more than two times the risk of Alzheimer’s disease (AD), the most expensive medical condition in the US. Although regular exercise is one way to potentially reduce AD risk, not everyone gains the same degree of neuroprotection from exercise. The proposed research will examine the effects of Cardio-Dance Fitness (as compared with Strength, Flexibility & Balance) on brain health and whether these effects are influenced by AD genetic risk in older African Americans with the goal of ultimately reducing AD risk and burden and potentially enhancing general health and longevity in this population.

PI_NAMEs: GLUCK, MARK A (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: active control;Aerobic Exercise;African American population;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Area;Behavior Therapy;behavioral clinical trial;Biological Markers;Biometry;Blood;brain health;Brain imaging;Brain region;burden of illness;caucasian American;Church;Clinic;Clinical Trials;Cognitive;cognitive benefits;cognitive testing;Communities;community engaged research;cost;Dancing;Data Analyses;dementia risk;Disparity;Dose;Education;Enrollment;Equilibrium;Exercise;exercise intervention;exercise prescription;exercise program;experience;fitness;fitness intervention;flexibility;Foundations;Frequencies;Functional Magnetic Resonance Imaging;Future;General Population;Genes;Genetic Determinism;Genetic Risk;Genotype;Goals;group intervention;Health;health assessment;health determinants;health disparity;Hematological Disease;Heterogeneity;high risk;Impairment;improved;Individual Differences;Intervention;intervention effect;Kinesiology;Knowledge;Learning;Light;Longevity;Low income;Magnetic Resonance Imaging;Measures;medial temporal lobe;Mediating;Medical;Memory impairment;Neighborhoods;neural;neurofilament;Neurology;neuroprotection;novel;older adult;Participant;Phase;Physicians;Population;post intervention;power analysis;pre-clinical;Prevalence;primary medical care;primary outcome;Privatization;programs;Public Health;Public Housing;Ramp;Randomized;Recommendation;recruit;Research;response;Rest;Risk;Risk Reduction;risk variant;Running;Safety;Sample Size;Scientist;sedentary;social;social determinants;Source;Symptoms;tau Proteins;Testing;Time;Variant;Work

PROJECT_TITLE: Determinants of Individual Differences in the Efficacy of Aerobic Exercise to Improve Brain Health and Reduce Alzheimer Disease Risk in Older African Americans


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative The goal of this project is to evaluate a data and knowledge-driven, AI-based clinical alerting system. The system generates alerts in real-time on unusual clinical orders that could be medical errors. A clinical trial will be conducted to evaluate whether such AI-based alerting modifies the behavior of caregivers in the intensive care unit.

PI_NAMEs: CLERMONT, GILLES ;HAUSKRECHT, MILOS  (contact);HUANG, DAVID TOM

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Address;adjudication;Area;Automobile Driving;Behavior;Caregivers;Cause of Death;Clinical;clinical care;Clinical Management;clinical practice;Clinical Trials;Complication;Computerized Medical Record;Computers;Conduct Clinical Trials;Data;data archive;data integration;Decision Support Model;Development;electronic medical record system;Evaluation;Evaluation Studies;Event;Funding;Generations;Goals;Growth;Healthcare;Human;human-in-the-loop;Hybrids;Immunosuppressive Agents;Impact evaluation;improved;Individual;Information Resources;Inpatients;Intensive Care Units;Intervention;Knowledge;knowledge base;knowledgebase;Learning;Literature;liver transplantation;Machine Learning;machine learning model;machine learning prediction;Medical Errors;Methodology;Methods;Modeling;Monitor;Operative Surgical Procedures;Outcome;Outpatients;Output;Patient-Focused Outcomes;Patients;Pattern;Performance;Pharmaceutical Preparations;Physicians;Pilot Projects;Play;Practice Management;Process;process improvement;Production;programs;prospective;Research;Resolution;Resources;Role;Running;secondary endpoint;System;Tacrolimus;Time;tool;Training;Work

PROJECT_TITLE: Learning alerting models for clinical care from EMR data and human knowledge


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: Chicago

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Chronically elevated VEGF, which promotes leakage of blood vessels, underlies numerous vision-robbing diseases. Anti-VEGF lowers the level of VEGF and thereby calms pathological blood vessels, resolves macular edema and restores vision. Identification of the molecular mediators of anti-VEGF’s beneficial effect is a largely unexplored opportunity, and the focus of this research proposal.

PI_NAMEs: KAZLAUSKAS, ANDRIUS  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Acute;Address;Adult;Basic Science;Biological Markers;Blood Vessels;Candidate Disease Gene;Cell Separation;cell type;Cells;Chronic;Clinical;clinically relevant;Data;design;Diabetes Mellitus;diabetic;differential expression;Disease;end stage disease;Endothelial Cells;Endothelium;Enzyme-Linked Immunosorbent Assay;experimental study;Exposure to;Extravasation;Exudative age-related macular degeneration;Fibrosis;fluorescein isothiocyanate dextran;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Glucose;Goals;Hour;Human;Immunofluorescence Immunologic;improved;In Vitro;in vitro Model;Invaded;Learning;macular edema;Mediating;Mediator;member;Modeling;Molecular;Monitor;Operative Surgical Procedures;Ophthalmologist;Pathologic;Patient Care;Patients;Permeability;Phase;Process;proliferative diabetic retinopathy;Quality of life;Quantitative Reverse Transcriptase PCR;recruit;Relaxation;Research Proposals;Retina;Retinal Detachment;Risk;sight restoration;standard of care;surgery outcome;System;Testing;Therapeutic;tissue culture;Traction;transcriptome sequencing;Treatment Factor;Vascular Endothelial Growth Factors;Vision;Vitrectomy;Work

PROJECT_TITLE: Anti-VEGF-mediated barrier closure

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Disability Research;Dissemination and Implementation Research;Health Services;Hypertension;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

PHR: Our objective for this research is to determine the efficacy of the polypill (one pill that contains fixed doses of antihypertensives, statin and aspirin) compared with usual care in reducing overall vascular risk among recent Ghanaian stroke survivors over 24 months. Participants in this trial will be enrolled from 12 hospitals including primary, district/regional, and tertiary levels across 6 regions (states) in Ghana to broadly capture patient and clinician experiences with the polypill and enhance the generalization of study findings. We also seek to develop an implementation strategy using a consultative, multi-stake holder engagement for routine integration and policy adoption of the polypill as a viable approach for post-stroke cardiovascular risk reduction in a resource-limited setting.

PI_NAMEs: OVBIAGELE, BRUCE  (contact);SARFO, FRED STEPHEN

PROGRAM_OFFICER_NAME: BENSON, RICHARD T

PROJECT_TERMS: Acute;Adherence;adjudication;Adoption;adverse outcome;Africa;Africa South of the Sahara;African;Age;Anti-Hypertensive Agents;arm;Aspirin;Blood Platelets;Blood Pressure;Blood Vessels;Brain Diseases;capsule;Cardiac Death;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;care coordination;Caring;carotid intima-media thickness;Cessation of life;Cholesterol;Chronic Disease;clinical care;clinical outcome assessment;Clinical Trials;cost;Country;Data;Death Rate;disability;Dose;Dyslipidemias;effectiveness evaluation;efficacy evaluation;Enrollment;Event;evidence base;experience;Formulation;Generic Drugs;Ghana;Goals;Grant;Guidelines;health care settings;Health Expenditures;Health system;Healthcare;high risk;Hospitals;Human Resources;Hybrids;Hypertension;implementation barriers;implementation evaluation;implementation facilitators;implementation outcomes;implementation strategy;improved;Incidence;International;Ischemic Stroke;Knowledge;LDL Cholesterol Lipoproteins;low and middle-income countries;Measures;Medical;Medical center;medication compliance;modifiable risk;mortality;Myocardial Infarction;Neurologist;Oral;Outcome;Outcome Measure;Participant;Patients;Persons;Pharmaceutical Preparations;Phase;pill;Policies;Population;Population Attributable Risks;Positioning Attribute;post stroke;Prevalence;Prevention;Prevention Guidelines;Prevention therapy;primary outcome;programs;Quality of life;randomized, clinical trials;Recommendation;Recurrence;Regimen;Research;Research Design;Resource-limited setting;Resources;Risk;Risk Factors;Risk Reduction;routine care;Safety;safety and feasibility;Sampling;Secondary Prevention;Serum;Site;Standardization;Stroke;stroke incidence;stroke outcome;stroke patient;stroke survivor;survival outcome;System;Testing;treatment as usual;United States National Institutes of Health;uptake;usual care arm;vascular risk factor;World Health Organization

PROJECT_TITLE: Stroke Minimization through Additive Anti-atherosclerotic Agents in Routine Treatment II Study


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD);Nutrition

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE  The gut microbiome plays roles in nutrition, immunity, metabolism, and several poorly understood neurological disorders. Suitable tools, however, do not yet exist for engineering the microbial communities that constitute the human microbiome. The proposed research introduces the first molecular tools to precisely understand the functions of microbiome communities in our health and disease in order to then delineate therapeutic interventions for diseases mediated by the gut microbiota, thereby addressing NIH's public health mission.

PI_NAMEs: DE LA FUENTE, CESAR  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;anti-microbial peptide;Antibiotics;Bacteria;Biochemical Pathway;Biological Markers;Bioreactors;Biosensing Techniques;Biosensor;Cardiovascular Diseases;Cells;chemical synthesis;Chemicals;Communities;computer science;computerized tools;design;Devices;Diabetes Mellitus;Disease;Electrical Engineering;Encyclopedias;Engineering;Etiology;experimental study;fecal transplantation;Foundations;fundamental research;Goals;gut bacteria;gut microbes;gut microbiome;gut microbiota;Health;Human;Human Microbiome;Hybrids;Immunity;in vivo evaluation;Individual;Inflammatory Bowel Diseases;Machine Learning;Mediating;Metabolism;Methodology;microbial community;Microbiology;microbiome;microbiome composition;microbiota;Mission;Molecular;molecular dynamics;Monitor;Nervous System Disorder;network models;novel therapeutics;nutrition;Obesity;pathogenic bacteria;Peptides;Play;Population;predictive modeling;Property;Public Health;Quantum Mechanics;real time monitoring;Research;Role;scaffold;screening;Source;synthetic biology;Systems Biology;targeted agent;temporal measurement;Testing;Therapeutic Intervention;tool;United States National Institutes of Health;Work

PROJECT_TITLE: Combining chemical and computational tools for predictive models of microbiome communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: KOTA KINABALU

ORG_COUNTRY: MALAYSIA

ORG_FIPS: MY

ORG_NAME: INFECTIOUS DISEASE SOCIETY KOTA KINABALU

PHR: Project Narrative The zoonotic malaria species P. knowlesi has emerged as a major public health problem across Southeast Asia, highlighted by the increasing number of reported cases in the epicentre of Malaysian Borneo, and threatens regional malaria elimination goals. In this state-wide malaria surveillance study in Sabah, Malaysia, we will evaluate these changing malaria trends using improved integrated molecular and serological detection platforms, and develop novel genomic based tools for P. knowlesi to look at how parasite population structure impacts on transmission and disease severity, including in the context of potential adaption to human-human transmission. Finally, we will use cutting-edge predictive geospatial risk mapping of P. knowlesi occurrence data and environmental and biological covariates in order to inform malaria control programs in Malaysia and other endemic countries in the region; promoting an improved targeted regional surveillance strategy and ability to prepare for and address the risk of increasing P. knowlesi transmission.

PI_NAMEs: RAJAHRAM, GIRI  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: 2019-nCoV;Address;anthropogenesis;Antigen Targeting;authority;Biodiversity;Biological;Borneo;burden of illness;Case Study;Cessation of life;Clinical;clinical phenotype;Communicable Diseases;Country;Culicidae;Data;Data Set;Databases;Detection;detection method;detection platform;Diagnosis;Diagnostic;Disease;disease transmission;Epidemiological trend;Epidemiology;Evaluation;Fever;forest;Genetic;Genome;Genomics;Genotype;Goals;Government;Health;Health care facility;Hospitals;Human;Immunity;improved;Incidence;Indonesia;Infection;land use;Malaria;Malaysia;Malaysian;Maps;Methods;Microscopy;Molecular;Monitor;Monkeys;novel;Outcome Study;Parasites;pathogen;Pattern;Plasmodium falciparum;Plasmodium knowlesi;Plasmodium vivax;Population;Population Distributions;population genetic structure;predictive tools;Pregnancy;Prevalence;Prevention;programs;Public Health;public health priorities;remote sensing;Reporting;Resolution;Risk;risk prediction;Sabah;Sampling;screening;Serology;Seroprevalences;Severity of illness;Southeastern Asia;Spatial Distribution;spatiotemporal;Structure;surveillance strategy;surveillance study;Surveys;targeted sequencing;Time;tool;training data;transmission process;trend;Update;Zoonoses

PROJECT_TITLE: Emerging zoonotic malaria in Malaysia: strengthening surveillance and evaluating population genetic structure to improve regional risk prediction tools

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative for the Center for Molecular Imaging Technology and Translation (CMITT) The Center for Molecular Imaging Technology and Translation (CMITT) is a National Center for Biomedical Imaging and Bioengineering located within the Gordon Center for Medical Imaging at the Massachusetts General Hospital. CMITT advances the methodology of PET/MR and covers the entire range of radiochemistry/radiopharmacy to image formation and processing including tomographic reconstruction and estimation/quantitation, paving the way for research applications and clinical translation.

PI_NAMEs: EL FAKHRI, GEORGES  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Acceleration;Adoption;Affect;Anatomy;Animal Model;Artificial Intelligence;attenuation;Australia;Award;B-Lymphocytes;Biochemical;Biochemical Reaction;Biological Markers;Biomedical Engineering;biomedical imaging;Brain;Canada;Cellular Membrane;chemical reaction;clinical translation;collaborative environment;Communities;Country;Data;data analysis pipeline;Data Science;deep learning;Demyelinations;design;Development;Direct Costs;Discipline;Disease;Drug Kinetics;Educational workshop;Electrophysiology (science);Endowment;Engineering;Environment;Evolution;Faculty;first-in-human;Funding;General Hospitals;Geography;Goals;Growth;Heart;Hospitals;Human;Image;image reconstruction;image translation;imaging agent;imaging facilities;imaging modality;imaging scientist;Imaging technology;Immune response;innovation;Institution;interest;International;Joints;kinetic model;Kinetics;Knowledge;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Malignant Neoplasms;Manufacturer;Maps;Massachusetts;Measurement;Measures;Medical center;Medical Imaging;Membrane Potentials;Methodology;Methods;mitochondrial membrane;Modality;Modeling;Molecular;molecular imaging;Molecular Probes;monocyte;Motion;nanoparticle;National Institute of Biomedical Imaging and Bioengineering;Normal tissue morphology;novel;Organ;Pathway interactions;Photons;Physicians;Physics;Physiological;Physiology;Positioning Attribute;Positron-Emission Tomography;Postdoctoral Fellow;Potassium Channel;Property;Radiochemistry;Radiolabeled;radioligand;Radiology Specialty;radiotracer;reconstruction;Research;Resources;Science;Scientist;Services;Signal Transduction;Site;Skeletal Muscle;skills;soft tissue;spectroscopic imaging;Students;System;T-Lymphocyte;Technology;technology development;temporal measurement;tomography;trafficking;Training;training opportunity;transfer learning;Translating;translational approach;Translations;Uncertainty;Vision;Visualization;Work

PROJECT_TITLE: Center for Molecular Imaging Technology & Translation (CMITT)


PROJECT_TERMS: Advisory Committees;Area;Biomedical Engineering;biomedical imaging;Clinical;Collaborations;Communication;Complex;course development;data sharing;Decision Making;Dedications;Development;Diagnosis;Disease;Ensure;Evaluation;expectation;experience;Feedback;follow-up;Funding;Goals;Grant;image translation;Imaging technology;improved;Individual;Infrastructure;Leadership;lectures;Location;Logistics;Medical Research;medical specialties;meetings;member;Mission;molecular imaging;Outcome;Phase;Positron-Emission Tomography;Procedures;programs;Progress Reports;Publications;quality assurance;Research;Research Personnel;Research Priority;Research Project Grants;Resources;Running;Science;Scientist;Sensitivity and Specificity;Services;Shapes;sound;Specific qualifier value;Structure;success;Supervision;synergism;Technology;technology development;timeline;Training;Training Programs;Translational Research;United States National Institutes of Health;Vision;willingness;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Algorithms;attenuation;Biological Markers;Cardiac;cardiac magnetic resonance imaging;Cardiotoxicity;Characteristics;Clinical;clinical practice;Collaborations;Compensation;Complex;computerized data processing;Computing Methodologies;CYP1A1 gene;CYP1A2 gene;Data;data acquisition;data framework;data space;deep learning;Degenerative polyarthritis;Demyelinations;Disease;extracellular;Family suidae;ferumoxytol;Fibrosis;Functional Imaging;Funding;Heart;Heart failure;human data;human subject;Image;image reconstruction;image translation;imaging biomarker;imaging modality;Imaging Techniques;Imaging technology;Immune response;improved;Individual;Inflammation;Label;Lipids;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Malignant Neoplasms;Maps;Measures;Membrane Potentials;Metabolic;Metabolism;Methodology;Methods;Modeling;Molecular;molecular imaging;monocyte;Morphologic artifacts;Motion;multimodality;Multiple Sclerosis;Myelin Water Imaging;Myocardial;Necrosis;new technology;Noise;novel;Pathogenesis;Performance;Physics;Physiological;Positron-Emission Tomography;Radiation therapy;reconstruction;remyelination;Research;Resolution;respiratory;Running;Sampling;Sarcoma;sequence learning;Software Tools;Structure;Techniques;Technology;Time;Tissue Model;Tissues;trafficking;transmission process;tumor;Water;Work

PROJECT_TITLE: TR&D1: Ultra-Fast Multiparametric MR Imaging Methods for Quantitative PET/MR


NIH_SPENDING_CATS: Cancer;Clinical Research;Pediatric

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Roadmap for America's Cancer Explorers for the 21st Century (RACE21) is an interdisciplinary program to expand the pipeline to a diverse 21st century cancer research workforce for the US. RACE21 will test an innovative pathway leading high school students to increased interest in cancer research, completion of a new Undergraduate Cancer Biology Major and careers in cancer research. RACE21 will simultaneously work to improve communication about health, especially cancer within minority communities.

PI_NAMEs: SHEVDE, LALITA A.;WYSS, J. MICHAEL (contact)

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Abbreviations;Adult;Advanced Malignant Neoplasm;Africa;African American;Alabama;American;anti-cancer research;Area;Awareness;Biology;Cancer Biology;Cancer Death Rates;Cancer Etiology;cancer health disparity;career;Clinical Trials;cohort;Communication;community center;Community Outreach;Comprehensive Cancer Center;Development;Disparity;Early Diagnosis;Early treatment;Education;experience;Exposure to;Family;Fellowship;Foundations;Future Generations;General Population;Goals;graduate school;Health;high school;High School Faculty;High School Student;improved;Individual;innovation;interest;Internships;Knowledge;Mainstreaming;male;Malignant Neoplasms;Mentors;Methods;Minority;minority communities;minority student;Modeling;Morbidity - disease rate;mortality;NCI Center for Cancer Research;next generation;Next Generation Science Standards;outreach;Parents;Pathway interactions;Phase;Positioning Attribute;Prevention;Program Development;programs;Race;Research;Research Personnel;Research Training;Resources;Schools;Science;science teacher;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;Secondary Schools;skills;Students;summer internship;summer research;teacher;Teacher Professional Development;Testing;Text;Training;twelfth grade;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;university student;Work;Youth

PROJECT_TITLE: Roadmap for America's Cancer Explorers for the 21st Century (Race 21)