ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Prevention;Rheumatoid Arthritis

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Rheumatoid arthritis (RA), one of the most common rheumatic conditions, is characterized by chronic inflammation. We will examine the role of lipid mediators (products of omega-3 and omega-6 fatty acids that are known to regulate inflammation) in the development of RA, focusing on the preclinical period prior to the onset of RA. Results from this work will provide the foundation for designing future prevention approaches and studies by identifying the combinations of lipid mediators that play a role in inflammation resolution in preclinical RA.

PI_NAMEs: NORRIS, JILL M (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Affect;Anti-citrullinated peptide antibody;Appearance;Autoimmune;Autoimmune Diseases;Autoimmunity;Biological Markers;Chronic;Classification;clinical diagnosis;cohort;comorbidity;cytokine;Data;design;Development;Disease;Disease Progression;disorder prevention;disorder risk;DNA Methylation;Elements;Environment;Enzymes;Etiology;Failure;Fatty Acids;follow-up;Foundations;Future;Gene Expression;Genes;Genetic;Genetic Predisposition to Disease;Health Expenditures;Homeostasis;Hydroxyeicosatetraenoic Acids;Immune response;Immune Targeting;improved;Individual;Inflammation;Inflammatory;Inflammatory Arthritis;inflammatory marker;innovation;Intervention;joint injury;lipid mediator;Longitudinal cohort;Lung;Measures;Mediating;Metabolism;Modeling;mucosal site;Mucous Membrane;novel;Omega-3 Fatty Acids;Omega-6 Fatty Acids;Pathogenesis;Pathogenicity;Pathway interactions;physically handicapped;Plasma;polygenic risk score;Polyunsaturated Fatty Acids;pre-clinical;prevent;Prevention;Prevention approach;preventive intervention;Principal Component Analysis;Process;progression risk;Publishing;Resolution;Rheumatoid Arthritis;Risk;Role;Serum;Site;Sputum;Testing;Time;Work

PROJECT_TITLE: The roles and mechanisms of inflammation resolution in the development of Rheumatoid Arthritis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: OD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE This project will identify early life environmental factors that contribute to neurodevelopmental impairments among children in the United State. These research findings can guide public health efforts to improve child health outcomes in the United States.

PI_NAMEs: FRY, REBECCA ;O'SHEA, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: MASH, CLAY

PROJECT_TERMS: 21 year old;Address;Advisory Committees;Area;Biological;Biological Markers;Chemicals;Child;Child Health;Childhood;cohort;Collaborations;Collection;Conceptions;Data;Data Collection;data harmonization;data platform;data sharing;Development;early childhood;Early identification;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Risk Factor;environmental stressor;epigenetic marker;Epigenetic Process;equity, diversity, and inclusion;Evidence based practice;Exposure to;extreme prematurity;Extremely low gestational age newborn;Family;follow-up;Generations;Genomics;Goals;Health;improved;Individual;Inflammation;inflammatory marker;innovation;Institutional Review Boards;Lead;Life;Longitudinal cohort;Manuscripts;Measures;medical specialties;Mentors;Metals;Nature;Neighborhoods;neurodevelopment;Neurodevelopmental Impairment;novel;Outcome;Participant;participant retention;Perinatal;Phase;Placenta;Policies;Population Heterogeneity;Pregnancy;Premature Birth;Production;programs;Proteomics;Protocols documentation;Public Health;Publications;Publishing;recruit;Research;Research Personnel;retention rate;Sample Size;Science;Scientist;Sex Differences;social;Specific qualifier value;stressor;System;United States;United States National Institutes of Health;working group;young adult

PROJECT_TITLE: Environment, Epigenetics, Neurodevelopment & Health of Extremely Preterm Children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Pediatric

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

PHR: NARRATIVE Due to an expansion in pediatric drug development research, there is an increasing need to train researchers with expertise in pediatric clinical pharmacology. This new application seeks to establish a “National Career Development Program for Researchers in Pediatric Clinical Pharmacology,” combining faculty expertise and resources across leading academic institutions with programs in pediatric clinical pharmacology. Upon completion of the career development training, scholars will be exceptionally well positioned to pursue impactful careers focused on promoting the safe and effective use of medications in children.

PI_NAMEs: BENJAMIN, DANIEL K.;GONZALEZ, DANIEL  (contact);JONES, BRIDGETTE L.;TREMOULET, ADRIANA H

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TERMS: Area;career;career development;Child;Childhood;Clinical;Clinical Pharmacology;Clinical Research;Clinical Trials;Data;Data Science;Development;Environment;Evaluation;experience;Faculty;faculty mentor;Future;Goals;Institution;Investments;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methods;National Institute of Child Health and Human Development;next generation;oral communication;Pharmaceutical Preparations;Pharmacoepidemiology;pharmacokinetics and pharmacodynamics;Pharmacology;Positioning Attribute;Program Development;programs;Publications;Reproducibility;Research;Research Ethics;Research Personnel;Research Project Grants;Resources;skills;Structure;Therapeutic;Training;training opportunity;Translational Research;Writing


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Depression;Genetics;Mental Health;Mental Illness;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Pregnancy;Social Determinants of Health;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: TUCSON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Intimate partner violence includes assault to the head, neck, and face, with approximately 90% of survivors reporting symptoms concordant with persistent post-concussion symptoms, wherein pregnancy is associated with increased intensity and frequency of physical assault. Like stress, drugs, and inflammation, traumatic brain injury (TBI) during pregnancy can increase the environmental risk for neurodevelopmental disorders in the children. The proposal extends strong proof-of-principle results to explore the outcomes of gravida TBI in mice on the neurobehavioral, neurocircuitry, and molecular phenotypes of offspring to better inform science, education, and policy making.

PI_NAMEs: LIFSHITZ, JONATHAN  (contact);QIU, SHENFENG

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Address;Adopted;Adult;Adult Children;Advocacy;Affect;Anxiety;anxiety reduction;assault;autism spectrum disorder;Behavior;behavioral outcome;behavioral phenotyping;Birth;Brain;brain circuitry;cell cortex;cell type;Cells;Child;Cognition;comparison control;Darkness;Data;Databases;density;depressive symptoms;Development;developmental disease;Diffuse;Disease;Education;Electrophysiology (science);Environmental Risk Factor;Epidemiology;experimental study;Face;Female;fetal;Frequencies;Gene Expression;Glutamates;Goals;Head;Health;Hippocampus;Immune;immune activation;Immune response;Infection;Inflammation;Intervention;intimate partner violence;Investigation;Knowledge;Laboratory Study;Lasers;Life;Light;Liquid substance;Live Birth;male;Maps;Marble;Measures;men;Mental Depression;Molecular;molecular marker;molecular phenotype;Morphology;morphometry;mouse model;Mus;Neck;neural circuit;neurobehavioral;neurodevelopment;Neurodevelopmental Disorder;Neuroimmune;Neurons;neuropsychiatry;Neurotransmitter Receptor;offspring;Outcome;Outcome Measure;patch clamp;Pathology;Percussion;Performance;Persons;Pharmaceutical Preparations;Phenotype;physical assault;Physiology;Policy Making;Post-Concussion Syndrome;postnatal;postsynaptic;Prefrontal Cortex;Pregnancy;pregnant;prepulse inhibition;presynaptic;Prevalence;protein expression;Proteins;Race;Reciprocal Social Interaction;Reporting;Research;response;Risk;Scanning;Schizophrenia;Science;Sex Bias;single-cell RNA sequencing;Sleep;social;Social Behavior;socioeconomics;Standard Model;Stress;Survivors;Symptoms;Synapses;synaptic pruning;Tail Suspension;Testing;transcriptome;transcriptomics;Traumatic Brain Injury;Ultrasonics;vocalization;Vulnerable Populations;Weaning;Weight;Western Blotting;Woman;young adult

PROJECT_TITLE: Gravida traumatic brain injury (TBI) impacts neurodevelopment of the offspring

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: OVERALL: NARRATIVE This is a new application for the DC-IDDRC, the District of Columbia Intellectual and Developmental Disabilities Research Center. The DC-IDDRC is dedicated to improving the lives of individuals with intellectual and developmental disabilities (IDDs) and their families by creating a strong translational research environment optimized for studying and defining the basic causes and mechanisms underlying IDDs, and designing new effective treatments and prevention strategies. To realize this mission, we provide a rich environment for performing fully translational IDD research in the four collaborating DC academic medical centers (Children’s National Hospital (lead), George Washington University, Howard University, and Georgetown University).

PI_NAMEs: GAILLARD, WILLIAM DAVIS (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Academic Medical Centers;Address;animal imaging;Animal Model;Animals;Area;Attenuated;autism spectrum disorder;Basic Science;Behavioral;behavioral phenotyping;bench to bedside;Bioinformatics;Biological Markers;Brain;Brain imaging;Caring;Cells;cellular imaging;Child;Clinical;clinical development;clinical outcome measures;Clinical Research;clinical translation;Cognitive;Collaborations;Communication;Communities;community research;comorbidity;Companions;Core Facility;cost effective;Dedications;design;Development;Developmental Disabilities;Disability research;Disease;District of Columbia;DNA analysis;DNA sequencing;Doctor of Philosophy;effective therapy;Enhancement Technology;Environment;Evaluation;Family;fetal;flexibility;fundamental research;Future;Genetic Diseases;Genomics;Goals;Grant;Growth;health disparity;Home;Hospitals;Human;human imaging;Image Analysis;image processing;Imaging Device;Imaging technology;improved;in vivo;Individual;innovation;Innovative Therapy;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Interdisciplinary Study;International;Intervention;Investigation;investigator training;Laboratories;Lead;Learning;Link;Maps;Mental Health;Messenger RNA;Microscopy;Mission;Molecular;molecular imaging;multidisciplinary;Neonatal Brain Injury;neurobehavioral;Neurobehavioral Manifestations;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;Neurosciences;novel;novel diagnostics;novel therapeutics;Optics;Outcome Measure;Pathology;Pilot Projects;Play;Postdoctoral Fellow;pre-clinical;prevent;Prevention approach;Prevention strategy;programs;quality assurance;recruit;Research;research data dissemination;Research Personnel;Research Project Grants;Research Support;Resources;response;Role;Science;Scientist;Statistical Data Interpretation;Strategic Planning;Structure;success;Sum;supportive environment;synergism;Technology;Testing;Therapeutic;Tissues;tool;Training;Training and Education;training opportunity;Translating;Translational Research;treatment strategy;Universities;Washington;Youth

PROJECT_TITLE: District of Columbia Intellectual and Developmental Disabilities Research Center (DC-IDDRC)


NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

PI_NAMEs: VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO (contact)

PROJECT_TERMS: Academic Medical Centers;Advisory Committees;Advocacy;Advocate;Applications Grants;Archives;Behavioral;bench to bedside;career;Charge;Child;Child Health;clinical investigation;Clinical Research;Clinical Trials;cohort;Collaborations;commercialization;Communication;Communities;Core Facility;cost;cost effective;Development;Developmental Disabilities;Devices;Disability research;District of Columbia;Education;Educational Activities;Effectiveness;Ensure;Fellowship;fetal;Fostering;Foundations;Future;Goals;Grant;high school;Home;Hospitals;Incubators;Infrastructure;innovation;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interdisciplinary collaboration;interest;investigator training;Knowledge;Laboratories;Leadership;lectures;Link;meetings;member;Mentors;Mission;Monitor;multidisciplinary;National Institute of Child Health and Human Development;Neonatal Brain Injury;neurodevelopment;Neurodevelopmental Disorder;new technology;open data;Participant;patient advocacy group;patient population;Play;programs;Public Relations;Publications;Quality Control;rare genetic disorder;recruit;Research;research and development;Research Personnel;Research Project Grants;Research Support;Resources;Role;Schedule;Series;Services;Site Visit;social media;Strategic Planning;Supervision;Surveys;Therapeutic Trials;Training;Training Activity;Training and Education;training opportunity;Training Programs;Training Support;Translational Research;Universities;Vision;Washington;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Brain Disorders;Data Science;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric

PI_NAMEs: GROPMAN, ANDREA LYNNE (contact)

PROJECT_TERMS: animal imaging;Area;autism spectrum disorder;bench-to-bedside translation;biobank;Bioinformatics;Biological Assay;biomarker development;Biometry;Cells;Characteristics;Child;Clinical;Clinical and Translational Science Awards;clinical practice;Clinical Research;clinical translation;Clinical Trials;Cognitive deficits;Collaborations;commercialization;Communities;Companions;complex data;cost effective;Country;COVID-19 pandemic;Data;data lake;data mining;Data Sources;data warehouse;design;Development;Diagnosis;digital health;digital platform;digital tool;Dimensions;Disability research;Disease;Disease Progression;District of Columbia;E-learning;Epidemiology;ethnic diversity;Evaluation;experience;Friends;Future;Genetic Variation;Genomics;Genotype;Goals;Health Technology;Healthcare;Hospitals;Human;human imaging;Incubators;Individual;Informatics;Infrastructure;innovation;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interest;Intervention Studies;Knowledge;Knowledge acquisition;Machine Learning;Managed Care;Mentors;Methods;Microscopy;motor deficit;National Center for Advancing Translational Sciences;neurobehavioral;neuroimaging;Neuropsychology;Nursing Faculty;Observational Study;Online Systems;open data;patient advocacy group;Patient Recruitments;Performance;phenomics;Phenotype;Population Heterogeneity;Practice Guidelines;Process;programs;Publications;racial diversity;Rare Diseases;recruit;Registries;Reporting;Research;Research Design;Research Personnel;research study;Resources;response;Sampling Studies;Science;Sensory;Services;skills;social media;Special Education;Structure;Technology Transfer;telehealth;Testing;text searching;Tissues;tool;Training;Translational Research;Translations;Vulnerable Populations;Washington;web site;Work

PROJECT_TITLE: Clinical Translation Core


ADMINISTERING_IC: MH

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: HONOLULU

ORG_NAME: EXPERIAD, LLC

ORG_STATE: HI

PHR: This Fast-Track SBIR will result in a new type of software system, called Goalspace, which will enable Behavior Analysts (BAs) to better incorporate parents and other caregivers into Applied Behavior Analysis (ABA), which is the primary behavioral intervention for children with autism. Goalspace will address critical shortfalls in current practice, and has the potential to have a major impact on autism treatment worldwide by increasing the amount of parent engagement in ABA therapy.

PI_NAMEs: JAKOBOVITS, REX M (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: applied behavior analysis;autism spectrum disorder;autistic children;Awareness;Behavior;Behavior Therapy;behavioral construct;Bundling;Caregivers;Cellular Phone;Child;Child Behavior;Child Rearing;Clinic;Complex;dashboard;Data;Data Aggregation;Data Collection;data visualization;design;Development;dosage;Electronics;evidence base;Face;Friends;Funding;improved;instrument;Intervention;Language;Location;Measures;Modeling;Monitor;neglect;Paper;Parents;Phase;Pilot Projects;pressure;Problem behavior;programs;Protocols documentation;prototype;Provider;Randomized, Controlled Trials;recruit;Research;Resources;Running;service providers;Services;skills;Small Business Innovation Research Grant;social skills;software systems;System;task analysis;Time;Training;United States National Institutes of Health;usability;Waiting Lists

PROJECT_TITLE: Goalspace: A Platform for Parent-Assisted Behavioral Interventions


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: NOTRE DAME

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: NARRATIVE Mechanical properties and forces the body are often modulated during disease initiation and progression. However, little is known about the response of immune cells to these mechanical cues, particularly at the tissue- length scale, and even in normal physiological settings. Establishing an omics-based understanding of functional immunological changes in response to mechanical perturbations will broaden our knowledge of “mechano- immunology” – a burgeoning subfield in basic biomedical sciences that in the near future will reveal new pathophysiological insights and targetable vulnerabilities for human disease.

PI_NAMEs: DATTA, MEENAL  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Affect;Animal Model;Antigens;Artificial Intelligence;Behavior;Biophysics;cell behavior;Cell Communication;Cells;cellular engineering;Disease;Disease Progression;Engineering;Future;Generations;Genetically Engineered Mouse;human disease;Image;Immune;Immune response;Immunocompetent;immunogenic;Immunologics;Immunology;in vivo;Inflammatory Response;insight;Knowledge;Laboratories;Length;mechanical force;mechanical properties;mechanical signal;Mechanics;Mediating;Motility;multiphoton microscopy;National Institute of General Medical Sciences;Organ;Pathologic;Phenotype;Physiological;programs;Research;Research Personnel;response;Science;single-cell RNA sequencing;Site;System;Testing;therapy resistant;Tissues;tool;trafficking;Transgenic Organisms;Translational Research;wound

PROJECT_TITLE: Establishing an immune mechanome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pain Research

ORG_CITY: BALTIMORE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative: The purpose of this study is to improve the assessment, diagnosis, and management of pain among residents living with dementia in nursing homes by testing the use of the new Pain Management Clinical Practice Guideline and compare differences in assessment, diagnosis and treatment of pain among male and female and Black versus White residents living with dementia.

PI_NAMEs: RESNICK, BARBARA  (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Acute;Address;Affect;Aggressive behavior;Aging;Agitation;Analgesics;associated symptom;Behavior;Behavioral Symptoms;Belief;Black race;Caring;Clinical;Clinical Practice Guideline;clinical translation;common symptom;Communities;Dementia;Diagnosis;Education;Effectiveness;effectiveness testing;Ethnic Origin;Ethnic Population;Evaluation;evidence base;Evidence based practice;experience;Facial Expression;Feedback;Female;Future;Gender;Goals;health disparity;health equity;home test;improved;Individual;innovation;Intervention;Knowledge;Long-Term Care;male;Measurement;Medicine;meetings;Mental Depression;Mentors;Modeling;Monitor;Nonpharmacologic Therapy;Nursing Homes;Nursing Research;older adult;Opioid;Pain;Pain intensity;Pain management;Pain Measurement;pain outcome;pain relief;pain sensitivity;Pharmaceutical Preparations;pharmacologic;Physical activity;Population;Positioning Attribute;Prevention;Process Assessment;psychological symptom;Quality of life;Race;racial population;Randomized;Recommendation;recruit;Reporting;response;sex;Sex Differences;Sleep disturbances;social;social cognitive theory;Societies;Techniques;Testing;Translating;Translations;treatment response;Use Effectiveness;verbal;vocalization;Withdrawal;Work

PROJECT_TITLE: Testing the Pain-CPG-EIT

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

PI_NAMEs: VILAIN, ERIC J. (contact)

PROJECT_TERMS: Adopted;base;Behavioral;bench to bedside;Bioinformatics;biomedical data science;Categories;Cell Physiology;Cells;ChIP-seq;Clinical;Clinical Data;clinical phenotype;Clinical Research;Collaborations;Complex;computerized tools;cost effective;Data;Dedications;design;Development;Diagnosis;Diagnostic;diagnostic development;Dimensions;Disability research;District of Columbia;DNA sequencing;early-career faculty;epigenetic regulation;epigenome;Equipment;Etiology;experience;Experimental Designs;fetal brain injury;Gene Expression;Genes;Genetic;Genetic Diseases;Genome;genome sequencing;genomic data;genomic signature;Genomics;improved;Individual;insight;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Interdisciplinary Study;International;Knowledge;large datasets;Maps;Methods;Methylation;Microanatomy;Mission;Molecular;molecular marker;Monitor;multidisciplinary;Neonatal Brain Injury;neurodevelopment;Neurodevelopmental Disorder;novel;Optics;Outcome;patient subsets;Pattern;Phenotype;Physiology;Population;Prevention;Productivity;Research Design;Research Personnel;Resolution;Role;single cell genomics;Technology;technology/technique;Therapeutic Intervention;Training;Training and Education;Training Support;transcriptomics;Translational Research;Translations;Variant

PROJECT_TITLE: Genomics and Bioinformatics Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Photoreceptors with Rhodopsin mutations can activate the Unfolded Protein Response (UPR) and cause retinal degeneration in Retinitis Pigmentosa. Here, I propose to identify and characterize new UPR pathways relevant to retinal degeneration in Drosophila models of Retinitis Pigmentosa.

PI_NAMEs: RYOO, HYUNG D (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Address;Adult;Affect;age acceleration;age related;Alleles;Arrestins;ATF6 gene;autosome;Binding;bZIP Protein;CCAAT-Enhancer-Binding Proteins;cell type;Cells;chromophore;Complex;Coupled;Data;Dimerization;Drosophila genus;Drosophila melanogaster;Endocytosis;Endoplasmic Reticulum;endoplasmic reticulum stress;Endosomes;experimental study;Eye;Family;Feedback;fly;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genetic Diseases;Genetic Models;genomic tools;Goals;GTP-Binding Proteins;Heterodimerization;Heterozygote;Homeostasis;Homologous Gene;Human;Impairment;interest;Laboratories;Light;Link;Mammals;Mediating;Membrane;misfolded protein;model organism;Modeling;mutant;Mutation;Organelles;Outcome;Pathologic;Pathway interactions;Patients;Photoreceptors;Physiological;Play;Property;protein folding;Proteins;proteostasis;Quality Control;response;Retina;Retinal Degeneration;Retinitis Pigmentosa;Rhodopsin;Role;sensor;Signal Induction;Signal Pathway;Signal Transduction;Site;Stress;Testing;trafficking;transcription factor

PROJECT_TITLE: Unfolded Protein Response in Drosophila models of Retinitis Pigmentosa

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PI_NAMEs: JAISWAL, JYOTI K (contact)

PROJECT_TERMS: 3-Dimensional;analytical tool;animal imaging;Area;Bioinformatics;Biomedical Engineering;Brain;Brain Mapping;Cell Communication;Cells;Cellular Structures;Child;Childhood;clinical translation;Collaborations;Color;Computer software;Conceptions;Confocal Microscopy;cost effective;Data;Data Analyses;Dedications;Defect;design;Development;digital pathology;Disability research;Disease;District of Columbia;Doctor of Philosophy;Educational workshop;Electron Microscopy;Electrons;Embryo;Ensure;Equipment;experience;Farm;fetal brain injury;Functional Imaging;Funding;Genetic;Genetic Diseases;Genomics;Goals;Hospitals;human imaging;Image;image visualization;imaging approach;Imaging Device;imaging platform;In Situ;in vivo;in vivo imaging;Individual;industry partner;Injury;innovation;instrument;instrumentation;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Intervention;investigator training;Ions;Laboratories;Light;light microscopy;loss of function;Maps;Metabolic;Microscope;Microscopic;microscopic imaging;Microscopy;Mission;Molecular Abnormality;Monitor;multi-photon;multiphoton microscopy;nanoscale;Neonatal Brain Injury;neural circuit;neural network;neurobehavioral;Neurodevelopmental Disorder;neuroregulation;new technology;next generation;Noise;Optics;optogenetics;Organ;Organism;Phenotype;Postdoctoral Fellow;Process;Quality Control;quantitative imaging;recruit;Research;Research Personnel;research study;Research Support;Resolution;Scanning;Scanning Electron Microscopy;Services;Signal Transduction;Structural defect;structural imaging;Structure;superresolution imaging;superresolution microscopy;symposium;Techniques;Technology;technology development;temporal measurement;three-dimensional visualization;tissue fixing;Tissues;tool;Training;Training Programs;ultra high resolution;United States National Institutes of Health;Universities;Validation;Visualization;Washington;Work

PROJECT_TITLE: Cell and Tissue Microscopy Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: NARRATIVE Acute respiratory distress syndrome (ARDS) has a highly detrimental impact on morbidity and mortality in surgical patients or following infections with pathogens, such as during the recent COVID-19 pandemic. Studies from our laboratory revealed that alveolar epithelial hypoxia-inducible factor HIF1A stabilization provides lung protection and is controlled by HIF-prolylhydroxylases (three isoforms exist, PHD1-3). We provide evidence that alveolar-epithelial PHD1 selectively controls HIF responses during ARDS and our proposed treatment approaches will enhance levels of HIF1A with concomitant lung protection during conventional ARDS or ARDS caused by SARS-CoV-2 infections.

PI_NAMEs: ELTZSCHIG, HOLGER K. (contact);YUAN, XIAOYI

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: 2019-nCoV;ACE2;Acute Respiratory Distress Syndrome;Address;Adenosine;Alveolar;alveolar epithelium;Anti-Inflammatory Agents;Attenuated;Binding Sites;carbohydrate metabolism;Clinical Trials;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19/ARDS;design;Doctor of Philosophy;experience;Exposure to;Feedback;Foundations;Genetic;genetic approach;Genetic Models;Genetic Transcription;Goals;HIF1A gene;Human;Hypoxia;Hypoxia Inducible Factor;In Vitro;in vivo;in vivo Model;Individual;Infection;Inflammation;Inflammatory Response;Injury;K-18 conjugate;Laboratories;Lung;lung development;Lung infections;lung injury;Mechanical ventilation;Mediating;MicroRNAs;Minor;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;Operative Surgical Procedures;Outcome;overexpression;pathogen;Pathway interactions;Patients;Perioperative;pharmacologic;Prevention;protective effect;Protein Isoforms;Pseudomonas aeruginosa;Regulation;Repression;response;Role;Sampling;SARS-CoV-2 infection;Sepsis;Signal Transduction;stressor;Therapeutic;transcription factor;Untranslated Regions;ventilation;Virus

PROJECT_TITLE: Functional Role of HIF-PHDs in ARDS

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Dietary Supplements;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE The proposed research is relevant to public health because the discovery of the mechanisms by which prematurity alters muscle growth and the identification of nutritional interventions to improve lean growth brings basic research closer to the translational level of improving the nutritional support of preterm infants. Thus, the proposed research that will use the preterm piglet as a model of the human preterm infant is relevant to the mission of the NIH as it will provide fundamental new knowledge on how the nutritional management of preterm infants can be optimized to improve their short- and long-term health.

PI_NAMEs: DAVIS, TERESA A (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Acute;Age;Amino Acids;Anabolism;Arginine;Attenuated;Basic Science;Birth;Blood flow;Body Composition;Cell Physiology;cell type;Childhood;Citrulline;Closure by clamp;Complex;Data;Deposition;Development;dietary;Dietary Intervention;Dietary Supplementation;Dose;effectiveness evaluation;Energy Metabolism;experience;Family suidae;feeding;Fetal Growth;FRAP1 gene;Generations;Goals;Growth;Health;Hormones;Human;Impairment;improved;improved outcome;in vivo;infancy;Infant;innovation;Insulin;Insulin Signaling Pathway;Knowledge;Laboratories;Leucine;Literature;Liver;liver metabolism;Mediating;Metabolic;metabolome;metabolomics;Methods;Mission;Modeling;Muscle;Muscle Proteins;Muscle satellite cell;Neonatal;neonate;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Nutrient availability;nutrition;Nutritional;Nutritional Support;obesity risk;Outcome;Pancreas;Peptide Initiation Factors;postnatal;premature;Premature Birth;Premature Infant;Process;Production;Proliferating;Protein Biosynthesis;protein degradation;protein intake;Proteins;Public Health;Publishing;Regulation;Research;Resistance;response;sensor;Signal Pathway;Signal Transduction;Skeletal Muscle;skeletal muscle growth;Supplementation;Term Birth;Testing;Thinness;transcriptome;transcriptomics;Translation Initiation;United States;United States National Institutes of Health;Uterus;Work

PROJECT_TITLE: REGULATION OF NEONATAL MUSCLE PROTEIN SYNTHESIS

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Childhood Injury;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PROJECT_TERMS: Affect;Algorithms;analytical method;Anatomy;animal imaging;Animal Model;Animals;autism spectrum disorder;Biochemical;Bioinformatics;Biological Markers;Brain;Brain Diseases;Brain imaging;Brain Injuries;career;Cells;Child;Clinical;Clinical Research;clinical translation;Cognitive;Collaborations;Computer software;congenital heart abnormality;cost;cost effective;Data;data integrity;data standards;Dedications;design;Development;Discipline;Disease;disease model;District of Columbia;Dyslexia;Education;Epilepsy;Evaluation;Faculty;fetal;flexibility;Fostering;Functional Imaging;Genomics;Hospitals;Human;human imaging;human model;Human Resources;hypoxic ischemic injury;Image;Imaging Device;imaging facilities;imaging modality;Imaging Techniques;Imaging technology;improved;in vivo;Inborn Errors of Metabolism;Individual;Infant;Infrastructure;Injury;innovation;Inpatients;Institution;instrument;instrumentation;Intellectual and Developmental Disabilities Research Centers;Intervention;Investments;Laboratories;Learning;Machine Learning;Magnetic Resonance Imaging;Measurement;Methods;Microscopy;Mission;Molecular;molecular imaging;Monitor;Motion;Neonatal;neonate;neural;neural circuit;neurobehavioral;neuroimaging;Neuronal Plasticity;neuroprotection;novel;novel imaging technology;Outcome;Pathway Analysis;Performance;perinatal stroke;Play;Population;Positron-Emission Tomography;pre-clinical;preclinical study;Protocols documentation;Quality Control;Research;Research Personnel;Research Project Grants;Resources;response;Risk;Role;Services;single photon emission computed tomography;Site;skills;Spectrum Analysis;structural imaging;Structure;Supervision;Targeted Research;Technical Expertise;Techniques;Technology;Time;Tissues;Training;Universities;Work

PROJECT_TITLE: Human and Animal Imaging Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Anorexia;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Depression;Eating Disorders;Mental Health;Mental Illness;Nutrition;Precision Medicine;Prevention;Serious Mental Illness;Suicide;Suicide Prevention;Violence Research

ORG_CITY: LOUISVILLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE This project will identify dynamic risk factors for suicidal ideation and behaviors within individuals with anorexia nervosa. The proposed research has significant public health relevance, as it will lead to personalized, novel, preventative efforts that disrupt suicidal behaviors before they occur in an extremely high-risk population. The proposed research is relevant to NIH’s precision medicine initiative, as it will identify within-person, risk factors, across multiple levels of analysis, leading to user-friendly personalized prevention programs and treatments, which incorporate dynamic interactions among core dimensions, symptoms, and physiology of individuals.

PI_NAMEs: LEVINSON, CHERI ALICIA (contact);SMITH, APRIL ROSE

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Acceleration;Accelerometer;Adult;Affect;Agitation;Algorithms;Anorexia Nervosa;Anxiety;Arousal;Behavioral;biological adaptation to stress;Cause of Death;Clinical;comorbidity;Computer software;Data;Data Collection;Death Rate;Devices;Diagnosis;Diagnostic;Dimensions;Distal;dynamic system;Eating Disorders;Ecological momentary assessment;emotion dysregulation;emotion regulation;Feeling suicidal;Female;follow-up;Friends;General Population;Goals;handheld mobile device;heart rate variability;high risk;high risk population;Hour;ideation;improved;indexing;Individual;individualized prevention;innovation;Intervention;Interview;Life;Link;Measurement;Mediator;Mental disorders;Mental Health;Methodology;Methods;mobile computing;mobile sensing;Modeling;Movement;Negative Valence;network models;novel;Outcome;Participant;Pathology;Pathway Analysis;Pathway interactions;Pattern;personalized medicine;Persons;Physiological;Physiology;Population;Precision Medicine Initiative;Precision therapeutics;prediction algorithm;Predictive Factor;prevent;Prevention;Prevention program;Process;Psychiatry;psychologic;Psychophysiology;public health relevance;Reporting;Research;Resistance;restrictive eating;Risk;Risk Factors;Science;severe mental illness;Shapes;Skin;Sleep disturbances;Sleep Wake Cycle;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Symptoms;Testing;theories;Thinking;Time;United States National Institutes of Health;user-friendly;Variant;wearable device;wearable sensor technology;Weight;Work

PROJECT_TITLE: Longitudinal Personalized Dynamics Among Anorexia Nervosa Symptoms, Core Dimensions, and Physiology Predicting Suicide Risk

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: Project Narrative: The Flow and Image Cytometry Shared Resource is an integral part of the Roswell Park Comprehensive Cancer Center (Roswell Park) Cancer Center Support Grant (CCSG) program (P30CA016056, PI Johnson). As the Associate Director of the Flow and Image Cytometry Shared Resource with over 35 years of relevant experience, Dr Minderman’s efforts are solely dedicated to supporting all 5 CCSG research programs with regards to developing, validating and optimizing flow and image cytometry-based assays, consultation on experimental design, data analysis, interpretation, reporting, education and oversight of maintenance/QC of the equipment in the Resource. His insightful intellectual and practical contributions on how cutting edge flow and image cytometry applications can aid the many NCI-funded projects at the cancer center and that of the CCSG program members in particular are invaluable. Continued funding of Dr Minderman as NCI Core-based Research Specialist will ensure the stability of an essential resource to Roswell Park’s CCSG program.

PI_NAMEs: MINDERMAN, HANS  (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Applications Grants;Area;Award;base;Biological Assay;Cancer Center;Cancer Center Support Grant;cancer research center director;career;Clinical;Collaborations;Comprehensive Cancer Center;Consult;Consultations;Data Analyses;Dedications;Doctor of Philosophy;Education;Ensure;Equipment;experience;Experimental Designs;Extramural Activities;Faculty;Flow Cytometry;Funding;Funding Opportunities;Grant;Image;Image Cytometry;Infrastructure;Investments;Laboratories;live cell imaging;Maintenance;member;Microscope;neoplasm immunotherapy;Positioning Attribute;Principal Investigator;programs;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Scientist;Specialist;tumor immunology;United States National Institutes of Health;Wages

PROJECT_TITLE: Associate-Director Flow and Image Cytometry Roswell Park ComprehensiveCancer Center


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PI_NAMEs: BERL, MADISON MEHALANI (contact)

PROJECT_TERMS: Adult;Anatomy;Animal Behavior;animal imaging;Animal Model;Animals;Anxiety;Assessment tool;Attention;autism spectrum disorder;awake;Behavior;Behavior assessment;behavior test;Behavioral;Behavioral Assay;bench to bedside;Bioinformatics;Biological;Biometry;Birth;Brain;Brain Diseases;catalyst;Cells;Child;Circadian Rhythms;Clinical Research;clinical translation;Clinical Trials;Cognition;Cognitive;cognitive function;Collaborations;Collection;Communities;comorbidity;Complement;Complex;Computer software;cost effective;data reduction;Data Storage and Retrieval;Database Management Systems;deep learning;Development;Diagnosis;digital;Disease;District of Columbia;Doctor of Philosophy;efficacy evaluation;emotional functioning;Epilepsy;Evaluation;executive function;Face;fetal;Fetal Alcohol Syndrome;Fiber;Fostering;Functional disorder;Functional Magnetic Resonance Imaging;gene therapy;Genes;Genetic;Genomics;Genotype;Goals;Human;human imaging;human model;Human Resources;Hypoxia;Image;in vivo;in vivo monitoring;Individual;innovation;Intellectual and Developmental Disabilities Research Centers;International;Intervention;Intervention Studies;Investigation;Knowledge;Language;Learning;Link;Measures;Memory;Methods;Microscopy;Mission;Modeling;Molecular;Monitor;Moods;Motor;Motor Activity;multiphoton imaging;Mus;Myelin;Neonatal Brain Injury;neural circuit;neural correlate;neurobehavior;neurobehavioral;neurobiological mechanism;Neurobiology;Neurodevelopmental Disorder;Neurons;Neuropsychology;Neurosciences;novel;optogenetics;Outcome;pharmacologic;Phenotype;Photometry;Physiological;Play;porcine model;pre-clinical;preclinical study;Prevention;Protocols documentation;Publications;Quality Control;Reproducibility;Research Personnel;Resources;Role;Sensory;social;social communication;Study models;success;symposium;System;Technology;Testing;Therapeutic;Tissues;tool;Training;Translating;translational approach;translational potential;Treatment Efficacy;Vision;Visuospatial

PROJECT_TITLE: Neurobehavioral Evaluation Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Transplantation

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE APOLLO-CPCC (CC05) comprises 11 clinical centers in the Northeastern United States. To support the APOLLO Consortium’s goal of enrolling all US kidney transplant recipients who received kidneys from African American donors as well as all African American living donors, we will build upon the infrastructure and collaboration we created in Phase 1. In Phase 2 we will leverage these relationships and resources to ensure continued recruitment of African American living donors, clinical data capture, and collection of urine albumin- to-creatinine ratio, biopsy slides and biospecimens (blood and urine) in accordance with the goals of the Consortium during the proposed follow up period.

PI_NAMEs: MOHAN, SUMIT  (contact);SAWINSKI, DEIRDRE

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Acceleration;Acute;Address;African American;African ancestry;Albumins;Allografting;American;Antibodies;APOL1 gene;Apolipoproteins;Bacterial Infections;Biopsy;Black race;Blood;Clinical;clinical center;Clinical Data;Clinical Investigator;cohort;Collaborations;Collection;Consent;Cost Savings;Counseling;Creatinine;Data;data registry;Data Set;digital pathology;Disparity;DNA;Donor person;Education;Enrollment;Ensure;Environmental Risk Factor;Epidemiology;ethnic difference;European;Evaluation;experience;Face;Failure;follow-up;Future;gene interaction;Genes;Genetic;genetic risk factor;Genotype;Geography;Goals;graft failure;Graft Survival;Health;Health Care Costs;Healthcare;high risk;Hispanic;HLA Antigens;Immunology;Immunosuppression;improved;Individual;Infrastructure;Kidney;kidney biopsy;Kidney Failure;Kidney Transplantation;Lesion;Living Donors;living kidney donor;Longterm Follow-up;Measures;Medical;Medical center;member;Meridians;multidisciplinary;New England;novel;Organ;Outcome;Outcomes Research;Participant;patient retention;Pattern;Pediatric Hospitals;Pennsylvania;Phase;Phenotype;Philadelphia;Policies;post-transplant;Prevalence;primary outcome;programs;prospective;Proteinuria;Quality of life;racial difference;Recording of previous events;recruit;Recurrent disease;Registries;Renal function;Reporting;repository;Research;Resources;Risk;risk variant;Role;Safety;secondary outcome;Serum;Site;Slide;Time;transplant centers;Transplant Recipients;Transplantation;United Network for Organ Sharing;United States National Institutes of Health;Universities;Urine;Variant;Virus Diseases

PROJECT_TITLE: 5/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Obesity

ORG_CITY: BIRMINGHAM

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Obesity is a highly prevalent condition that exacts a high price in suffering for afflicted individuals and economically for society. Causes are complex, manifold, and only partially understood and available treatments are only modest in efficacy. New scientific insights are badly needed and training a new generation of multidisciplinary obesity researchers is essential to meet that objective.

PI_NAMEs: GOWER, BARBARA A (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TITLE: UAB Pre-Doctoral Training Program in Obesity-Related Research

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative:Hypertension (HTN) accounts for the greatest portion of racial disparities in mortality between blacks and whites, and despite the proven benefits of optimal HTN treatment, too few Black patients achieve optimal blood pressure (BP) control due to barriers at the patient, physician, health systems, and community- levels of care. This application provides a unique opportunity to address this public health challenge by using practice facilitation as a practical and sustainable implementation strategy to support the implementation and evaluation of three multi-level evidence-based interventions (nurse case management, home BP monitoring, and use of Community Health Workers) delivered as an integrated community-clinic linkage model [Practice support And Community Engagement (PACE) across 20 primary practices within NYU Langone Health in NYC and, in partnership with an established Community-Clinic-Academic Advisory Board and HealthFirst (NYC's largest Medicaid payer). The study's findings will provide a practical and sustainable system of hypertension management that harnesses existing clinical and community resources to build capacity for primary care practices to effectively address poor hypertension control in vulnerable populations.

PI_NAMEs: ISLAM, NADIA S;OGEDEGBE, OLUGBENGA G. (contact);SCHOENTHALER, ANTOINETTE M

PROGRAM_OFFICER_NAME: ILIAS, MALIHA R

PROJECT_TERMS: Address;Adherence;Adoption;Behavioral;black patient;Black Populations;Black race;Blood Pressure;blood pressure control;Blood Pressure Monitors;care coordination;Caring;Case Management Nurse;Clinic;Clinical;Clinical effectiveness;Communication;Communities;community barrier;community based participatory research;community clinic;community clinical linkage;community engaged intervention;community engagement;community engagement process;Community Health Aides;Consolidated Framework for Implementation Research;cost effectiveness;Counseling;Data;Decision Making;design;disparity reduction;Dissemination and Implementation;Effectiveness;electronic health record system;Evaluation;evidence base;Evidence based intervention;Exhibits;experience;food insecurity;Goals;Guidelines;Health;Health system;Home;Home Blood Pressure Monitoring;housing instability;Hypertension;hypertension control;hypertension treatment;implementation evaluation;implementation fidelity;implementation framework;implementation outcomes;implementation process;implementation protocol;implementation research;implementation strategy;implementation/effectiveness;improved;Infrastructure;Insurance Carriers;Intervention;Medicaid;Methods;Minority Groups;minority patient;Modeling;Monitor;mortality disparity;Names;New York City;Nurses;patient navigation;Patients;Pharmaceutical Preparations;Phase;Physicians;pilot test;Primary Care;primary care practice;primary care setting;primary outcome;Process;Proctor framework;Provider;provider factors;Public Health;racial disparity;recruit;Resources;Risk;routine care;secondary outcome;Site;Social support;sound;System;telemonitoring;Testing;Titrations;Training;Training Support;Transportation;treatment as usual;Vulnerable Populations;Work

PROJECT_TITLE: Actions to Decrease Disparities in Risk and Engage in Shared Support for Blood Pressure Control (ADDRESS-BP) in Blacks


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

PHR: Project Narrative The proposed research is relevant to public health because it will aid in the transition to comfort-oriented care for patients with advanced cancer who are nearing the end of life and, in doing so, improve patient quality of life while reducing use of low-value, aggressive end-of-life care. Thus, the proposed research aligns with the mission of Agency for Healthcare Quality and Research to produce evidence to make health care higher quality and affordable.

PI_NAMEs: RAY, EMILY MILLER (contact)

PROGRAM_OFFICER_NAME: WYATT, DERRICK

PROJECT_TITLE: Evaluation of end-of-life best practices and implementation of a tool to predict near-term death among patients with metastatic breast cancer in an oncology clinic

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PI_NAMEs: KENWORTHY, LAUREN  (contact)

PROJECT_TERMS: 18 year old;Adaptive Behaviors;Address;Adolescence;adolescent with autism spectrum disorder;Attention;autism spectrum disorder;autistic children;Behavior;behavior measurement;behavior prediction;Behavioral;behavioral response;bench to bedside;Biological Markers;Brain;Canis familiaris;case control;Categories;Child;clinical translation;Cognitive;Cognitive Therapy;comorbidity;Computer Models;Coupled;design;Development;District of Columbia;Effectiveness of Interventions;Enrollment;Environment;Executive Dysfunction;executive function;Exhibits;experience;Feedback;flexibility;Functional Magnetic Resonance Imaging;Generations;Heterogeneity;Impairment;improved;Individual;Individual Differences;individual variation;Infrastructure;Intellectual and Developmental Disabilities Research Centers;Intelligence;Intervention;intervention effect;Investigation;Knowledge;Learning;Learning Skill;Light;Link;Medial;medial temporal lobe;Memory;Mental Health;Methodology;Modeling;neural;neural correlate;neurobehavioral;neuroimaging;neuromechanism;novel;Outcome;Outcome Measure;Performance;personalized medicine;Prediction of Response to Therapy;Prefrontal Cortex;prototype;Recording of previous events;Research Personnel;Resources;response;Rest;skills;social;social skills;Specificity;success;Testing;Time;transfer learning;Treatment outcome;treatment response;Universities;wasting;Youth

PROJECT_TITLE: Intervention-induced plasticity of flexibility and learning mechanisms in ASD


NIH_SPENDING_CATS: Aging;Chronic Obstructive Pulmonary Disease;Clinical Research;Lung;Physical Rehabilitation;Prevention;Rehabilitation

PHR: PROJECT NARRATIVE Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a major public health problem particularly in older American adults. Current treatments are not effective at preventing AECOPD. I will utilize pulmonary rehabilitation, a safe and effective treatment for prevention of AECOPD, as a model to identify modifiable biologic targets to inform future therapeutic drug development.

PI_NAMEs: MOSHER, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;Active Learning;Acute;Address;Adult;age related decline;American;Award;biobank;Biological;Biological Markers;Biology of Aging;Capsicum;career;career development;Caring;CD28 gene;CDKN2A gene;Characteristics;Chronic Obstructive Pulmonary Disease;Clinical Trials;Collaborations;Communities;Core Facility;cytokine;Data;design;Development;disorder prevention;disorder risk;drug development;Educational Intervention;effective therapy;Elderly;Enrollment;Event;exercise intervention;exercise training;experience;Fostering;Frequencies;Funding;Future;Geriatrics;Goals;health related quality of life;Hospitalization;human old age (65+);immune system function;Immunity;Immunology;immunosenescence;Impairment;improved;ineffective therapies;Intervention;Investigation;K-Series Research Career Programs;Knowledge;Laboratories;Manuscripts;Measurement;Measures;Methodology;Modeling;Molecular;older adult;older patient;Patients;pharmacologic;Pharmacological Treatment;phenotypic biomarker;physical conditioning;Physical Performance;Physicians;Plasma;Play;Preparation;prevent;Prevention;programmed cell death protein 1;programs;promote resilience;Property;Public Health;Publishing;pulmonary rehabilitation;Pulmonology;Recovery;Research;Respiratory Tract Infections;Role;Scientist;senescence;senescence associated secretory phenotype;senescent cell;senolytics;skill acquisition;Standardization;Structure;symposium;T-Cell Proliferation;T-Lymphocyte;Testing;Therapeutic;translational scientist;Viral Respiratory Tract Infection;Vulnerable Populations

PROJECT_TITLE: GEMSSTAR PERSPIRE-COPD


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Patient Safety;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Substance Misuse;Violence Research

ORG_NAME: HUNTER COLLEGE

PHR: Project Narrative Despite the high incidence of posttraumatic stress disorder (PTSD), substance use disorders (SUD), and chronic physical health problems among transgender and gender diverse (TGD) populations, research that can inform the development of transdiagnostic, integrated PTSD-SUD interventions for this population is lacking. The proposed dissertation study will address this clinical science gap by utilizing ecological momentary assessment to identify transdiagnostic mechanisms of co-occurrence among gender minority stress (e.g., TGD-based discrimination), susbtance use, and PTSD symptoms in a sample of trauma-exposed TGD adults, and will be among the first to utilize measures of neuroendocrine stress reactivity to examine physiological and physical health consequences of PTSD-SUD co-occurrence in a high-risk population. This study is consistent with NIDA priorities for research on social determinants of health and will inform the development of patient-centered models of care for minoritized populations more broadly by identifying specific and modifiable clinical targets that cut across experiences of chronic stigma-related stress, PTSD, and SUD in a vulnerable population.

PI_NAMEs: LIAUTAUD, MADALYN MICHELE (contact)

PROGRAM_OFFICER_NAME: COLLIER KIDEMU, KEVA WONTORIA

PROJECT_TERMS: Adult;Behavior;Biological;biological adaptation to stress;biopsychosocial;Cannabis;Caring;Chronic;Chronic Disease;cisgender;Client;Clinical;clinical center;clinical decision-making;clinical diagnostics;clinical risk;Clinical Sciences;Clinical Treatment;Collection;comorbidity;cost;Criminal Justice;Data;design;Development;Diagnostic;Discrimination;Disease;disorder risk;Disparity;Drug Addiction;Drug usage;drug use behavior;Ecological momentary assessment;emotion dysregulation;emotion regulation;Empirical Research;epidemiological model;Evaluation;evidence base;experience;Exposure to;Funding;Future;gender diverse;Gender Identity;gender minority group;gender minority stress;Goals;Health;health equity;Healthcare;high risk population;Hormones;Hydrocortisone;Illicit Drugs;impaired productivity;Incidence;Individual;Individual Differences;innovation;internalized stigma;Interpersonal Violence;Intervention;Interview;Life;Link;Measures;Mediating;Mediator;Methods;Minority;Minority Groups;minority stress;Modeling;modifiable risk;Morbidity - disease rate;mortality;multiple chronic conditions;National Institute of Drug Abuse;Neurosecretory Systems;Nicotine;novel;Parents;Participant;Pathway interactions;patient oriented;Patient Self-Report;Pattern;Persons;Pharmaceutical Preparations;physical conditioning;Physiological;Population;Population Heterogeneity;Population Intervention;Post-Traumatic Stress Disorders;Prevalence;prospective;psychobiologic;psychologic;psychosocial;Public Health;Quality of life;Recording of previous events;recruit;Research;Research Priority;Resources;Risk;Risk Factors;Salivary;salivary immunoassay;Sampling;Severities;Shame;Shapes;social;Social Environment;social health determinants;social stigma;Source;Stress;stress reactivity;Structure;substance use;Substance Use Disorder;Surveys;Symptoms;syndemic;System;theories;transgender;trauma exposure;United States National Institutes of Health;Violence;violence exposure;virtual;Vulnerable Populations;Work

PROJECT_TITLE: Identifying Transdiagnostic Intervention Targets for PTSD-SUD Comorbidity in a Vulnerable Population: A Mixed-Method Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)]


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Individuals with inherited platelet disorders can have frequent and sometime lethal episodes of uncontrolled bleeding, and an early genetic diagnosis can benefit clinical management. However, genetic diagnosis is often not possible without studies that define how the genetic change affects platelets, which have been historically challenging. This project implements a new, faster, and more disease relevant approach to test how a panel of genetic changes affect a specific inherited platelet disease.

PI_NAMEs: ROWLEY, JESSE  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Adult;Affect;Agonist;Alpha Granule;Amino Acids;Applied Genetics;Binding;Blood Coagulation Disorders;Blood Platelet Disorders;Blood Platelets;CD34 gene;Cell Differentiation process;Cell Line;Cells;Classification;Clinical;clinical application;Clinical Management;clinically relevant;Cloning;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;CRISPR/Cas technology;Data;Databases;Decision Making;Diagnosis;Diagnostic;Disease;disease classification;DNA;Evaluation;exome sequencing;Fibrinogen;functional mimics;Future;Gene Expression;gene function;Gene Modified;Generations;Genes;Genetic;genetic disorder diagnosis;genetic variant;Genetic Variation;genome sequencing;genomic locus;Goals;Hamsters;Hemorrhage;high throughput screening;High-Throughput DNA Sequencing;High-Throughput Nucleotide Sequencing;Human;human DNA;Immunodeficient Mouse;in vivo;indexing;Individual;Inherited;innovation;Insertion Mutation;insight;Integrins;Investigation;Libraries;loss of function;Measures;Mediating;Megakaryocytes;Methods;Missense Mutation;Modeling;Modification;mouse model;Mus;Mutagenesis;mutant;Mutation;novel;Ovary;overexpression;PAC1 phosphatase;Pathogenicity;Patients;Phenotype;Physiological;Physiology;platelet function;platelet phenotype;Point Mutation;Positioning Attribute;precision medicine;Production;Proteins;repaired;Reporting;Research;response;Single-Stranded DNA;Sorting;Specific qualifier value;Surveys;targeted sequencing;Testing;Thrombasthenia;Time;tool;Umbilical Cord Blood;Validation;Variant;variant of unknown significance;virulence gene;Virus;Work

PROJECT_TITLE: Evaluation of genetic variants affecting platelet function with CRISPR HDR in human megakaryocytes

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: Project Narrative This project will delineate a novel clock-Akt-mTOR regulatory axis involved in temporal modulation of skeletal muscle nutrient metabolism and muscle mass regulation. The outcome of this proposal may uncover a circadian etiology underlying muscle anabolic and metabolic defects in sarcopenia and provide the mechanistic basis for clock-targeting interventions.

PI_NAMEs: MA, KE  (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: Ablation;Aging;ARNTL gene;Atrophic;Attenuated;Automobile Driving;Autophagocytosis;Cells;ChIP-seq;circadian;Circadian desynchrony;Circadian Dysregulation;circadian pacemaker;circadian regulation;Coupled;Defect;Etiology;feeding;FRAP1 gene;Functional disorder;gain of function;Genetic;Genetic Models;genetic testing;Genetic Transcription;Glucose;glucose metabolism;Goals;Growth;Homeostasis;Impairment;improved;Insulin;Insulin Resistance;insulin sensitivity;Intervention;Knowledge;Label;Life Style;Link;lipid metabolism;Lipids;loss of function;Maintenance;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Modeling;Modernization;Molecular;mouse model;mTOR Signaling Pathway;multiple omics;Muscle;Muscle Development;Muscle Fibers;muscle form;Muscle Proteins;Muscular Atrophy;nobiletin;novel;Nutrient;nutrient metabolism;Obesity;Outcome;Output;Pathway interactions;Periodicity;pharmacologic;Physiological;PIK3CG gene;Play;Prevalence;prevent;Protein Biosynthesis;protein degradation;protein metabolism;Proteins;Proteomics;proteostasis;Regulation;Research;Research Support;Resistance;response;Role;sarcopenia;sarcopenic obesity;sensor;shift work;Signal Transduction;Skeletal Muscle;Stimulus;Testing;Therapeutic;Time;Transcription Coactivator;Transcriptional Regulation;transcriptomics;Translations;Wasting Syndrome

PROJECT_TITLE: Circadian clock and temporal control in nutrient metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-L(02)M]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative Epilepsy (recurrent seizures) is a serious neurological disorder that can develop as consequence of viral infection and inflammation in brain. Expanding our understanding on the mechanism of how inflammation leads to seizures, will allow for the development of novel therapeutical treatments to prevent or even cure epilepsy.

PI_NAMEs: DE PAULA E SILVA, ANA BEATRIZ  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: acquired epilepsy;Acute;acute infection;Address;Adult;Affect;Animal Model;Anti-Inflammatory Agents;astrogliosis;Attention;Automobile Driving;Biological Assay;Biotinylation;Blood;Brain;brain parenchyma;career;Cells;Central Nervous System;Central Nervous System Infections;Central Nervous System Viral Diseases;Chronic;cytokine;Data;Development;Disease;Down-Regulation;Encephalitis;Epilepsy;experimental study;Flow Cytometry;GABA Receptor;Generations;Genetic;Gliosis;Grant;Hippocampus;Homeostasis;improved;Infection;Infiltration;Inflammation;Inflammatory;Interleukin-10;Interleukin-6;Interleukins;Intervention;Knowledge;Laboratories;Lead;Learning;Macrophage;Measures;Mentors;Microglia;MicroRNAs;Modeling;Motor Seizures;mouse model;Mus;Myeloid Cells;Nervous System Disorder;neuroinflammation;neuron loss;Neurons;new therapeutic target;novel;novel therapeutics;Pathogenesis;Pathologic;Pathway interactions;Patients;peripheral blood;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Play;Population;Positioning Attribute;prevent;receptor;receptor expression;Recombinant Proteins;Recurrence;Refractory;Research;response;Role;Seizures;Severities;Severity of illness;Signal Pathway;Signal Transduction;skills;Source;Stimulus;Techniques;Temporal Lobe Epilepsy;Testing;therapeutic target;Time;tissue repair;Tissues;TMEV;TNF gene;trafficking;Training;transcriptome sequencing;Transforming Growth Factors;Viral;Viral Encephalitis;Virus;Virus Diseases;Work

PROJECT_TITLE: The role of Infiltrating Macrophages in Seizure Generation Following CNS Infection


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Precision Medicine;Rheumatoid Arthritis

PHR: PROJECT NARRATIVE Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood and requires long-term treatment to prevent pain, physical limitations, and permanent impairment. Due to uncertainty around best medication choices and treatment options, shared decision making (SDM) is recommended for treatment decisions, but a tool to assess patient preferences and incorporate SDM into routine clinical care does not exist. Through this project and training plan, I will gain expertise in medical decision methodology by comparing preference priorities between adolescents with JIA and their parents, developing a decision aid, and then pilot test the decision aid to facilitate shared decision making between adolescents, parents, and providers.

PI_NAMEs: MANNION, MELISSA  (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Achievement;adherence rate;Adolescent;adolescent patient;Adoption;Affect;arm;Asthma;care providers;career;Caregivers;Caring;Characteristics;Child;Childhood;Chronic Childhood Arthritis;Chronic Disease;Clinic;Clinic Visits;Clinical;clinical care;Conflict (Psychology);Decision Aid;Decision Making;disability;Disease;Disease Outcome;Disease-Modifying Second-Line Drugs;Drug Prescriptions;Epidemiology;evidence based guidelines;experience;experimental study;feasibility trial;Frequencies;Goals;Impairment;improved;improved outcome;Individual;Insulin-Dependent Diabetes Mellitus;Knowledge;learning network;Medical;medication compliance;Mental Depression;Mentors;Methodology;Methods;multidisciplinary;Outcome;Pain;parental influence;Parents;Patient Outcomes Assessments;Patient Preferences;Patient-Focused Outcomes;Patients;Pediatrics;Personal Satisfaction;personalized decision;personalized medicine;Pharmaceutical Preparations;Phenotype;Physical Function;pilot test;Positioning Attribute;preference;prevent;Process;Provider;Qualitative Methods;Qualitative Research;Quality of life;Randomized, Controlled Trials;Recommendation;reduce symptoms;Reporting;Research;Research Personnel;Rheumatism;rheumatologist;Rheumatology;Risk;Route;satisfaction;Science;shared decision making;side effect;Site;skills;Social Functioning;symposium;Symptoms;Techniques;Time;tool;Training;treatment and outcome;treatment effect;Treatment Step;Uncertainty;user centered design

PROJECT_TITLE: Developing a tool to support shared decision making in JIA between adolescents, parents, and providers

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: NARRATIVE Persons with HIV (PWH) on anti-retroviral therapy can have near-normal lifespan, but many suffer greatly from HIV-related non-aids conditions (HANA) that manifest themselves as accentuated aging and limited evidence suggests that this happens only in those PHW infected with cytomegalovirus (CMV). We have discovered new biomarkers of CMV infection and propose to use them to test whether and how CMV may be driving accentuated aging in PWH. Results should help to set future CMV-specific treatments to achieve successful aging with HIV.

PI_NAMEs: NIKOLICH, JANKO Z. (contact);TOOSIZADEH, NIMA

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Acute;Adult;Age;age acceleration;Age related comorbidities;Aging;aging related;Antigens;antiretroviral therapy;Automobile Driving;Autonomic Dysfunction;B-Lymphocytes;Biological Markers;Biological Response Modifiers;Cardiac;Cardiovascular Physiology;CD28 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Chronic;Chronic Disease;Chronic Kidney Failure;Clinical Trials;Cognitive;cognitive ability;Cognitive deficits;cognitive function;cognitive testing;cohort;Collaborations;comorbidity;Coupled;cytokine;Cytomegalovirus;Cytomegalovirus Infections;Data;disability;Disease;DNA;Elderly;exhaustion;Exhibits;experience;experimental study;falls;fitness;frailty;functional decline;functional status;Future;Geriatric Assessment;healthspan;HIV;HIV Infections;HIV Seronegativity;Hyperlipidemia;Hypertension;Immune;immune function;Immune response;Immunity;Immunologic Markers;Impaired cognition;Impairment;improved;Individual;Industrialization;Inflammaging;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;insight;Lead;Life;Life Expectancy;life span;Link;Malignant Neoplasms;Measures;Mediating;Mental Depression;mortality;Motility;Motor;multimodality;multiple chronic conditions;Multivariate Analysis;Natural Killer Cells;Neutralization Tests;neutralizing antibody;NK Cell Activation;Non-Insulin-Dependent Diabetes Mellitus;older adult;Older Population;Participant;Persons;Pharmacotherapy;Phenotype;Predictive Value;premature;Premature aging syndrome;Production;prospective;Publications;Quality of life;Questionnaires;Recording of previous events;response;Role;Sampling;sensor;seropositive;sex;SF-36;Syndrome;systemic inflammatory response;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Tissues;tool;Upper Extremity;Variant;vascular inflammation;Viral;Viral Load result;Work

PROJECT_TITLE: The role of CMV in HIV-associated accentuated aging

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Transplantation

PHR: Project Narrative Specific variants in the gene encoding apolipoprotein L1 (APOL1), which are generally restricted to persons with recent African ancestry, have been associated in retrospective analyses with an increased risk of end- stage native-kidney disease and shorter survival of kidney transplants. The proposed study will increase the number of living kidney donors and extend the follow-up of recipients of kidneys from deceased or living donors enrolled in the prospective APOLLO study that is examining the impact of APOL1 variants on kidney function while considering various environmental or comorbid conditions that can damage kidneys. The findings from this study have the potential to transform allocation of kidneys for transplantation, improve survival of transplanted kidneys, better inform potential kidney donors with recent African ancestry of the risks of donation, and provide a better understanding of the mechanisms whereby these genetic variants produce kidney disease.

PI_NAMEs: AGARWAL, GAURAV  (contact);MANNON, ROSLYN B

PROJECT_TERMS: Acceleration;Acute;Address;African American;African American population;African ancestry;Alabama;Albumins;Allografting;American;Antibodies;Apolipoproteins;Arkansas;Bacterial Infections;Biopsy;Blood;Child;Clinical;clinical center;Clinical Data;cohort;comorbidity;Consent;Cost Savings;Counseling;Creatinine;Data;digital pathology;Disparity;DNA;Donor person;Education;Enrollment;Ensure;Environmental Risk Factor;ethnic difference;European;Evaluation;Face;Failure;follow-up;Foundations;gene interaction;Genes;Genetic;genetic risk factor;genetic variant;Genotype;Geography;graft failure;Graft Survival;Health Care Costs;high risk;HLA Antigens;Immunosuppression;improved;Individual;Informed Consent;Kidney;kidney allograft;kidney biopsy;Kidney Diseases;Kidney Failure;Kidney Transplantation;Lead;Lesion;Living Donors;living kidney donor;Longterm Follow-up;Measures;Medical;Medical center;Mississippi;novel;Organ;organ allocation;Outcome;Outcome Assessment;Outcome Study;Participant;Pattern;Persons;Phase;phase 2 study;Phenotype;Policies;post-transplant;Prevalence;primary outcome;Process;programs;prospective;Proteinuria;Quality of life;racial difference;recruit;Recurrent disease;Registries;renal damage;Renal function;Reporting;repository;Research;Risk;risk variant;Role;Safety;Science;secondary outcome;Serum;Site;Slide;South Carolina;Time;Transplant Recipients;Transplantation;United Network for Organ Sharing;United States National Institutes of Health;Universities;Urine;Variant;Virus Diseases

PROJECT_TITLE: 4/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetic Testing;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: PROJECT NARRATIVE Liquid biopsy is a useful clinical diagnostic in cancers where known simple mutations can be identified and monitored, but current liquid biopsy techniques are less effective in cancers with few recurrent simple mutations, such as osteosarcoma (OS) and rhabdomyosarcoma. The studies in this proposal will comprehensively interrogate a mutation independent cell-free DNA and RNA (cfDNA/cfRNA) multi-parameter liquid biopsy approach in a spontaneous canine cancer model. This methodology aims to improve the sensitivity of cancer detection using liquid biopsy and enable rapid detection of early drug resistance across a wide range of genomically complex sarcomas.

PI_NAMEs: GARDNER, HEATHER LYNN (contact)

PROGRAM_OFFICER_NAME: VONKOLLMAR, DESIREE

PROJECT_TERMS: Aftercare;Algorithms;Animal Disease Models;Animal Model;biobank;Biological Assay;Biological Models;Biopsy;Blood;cancer cell;Cancer Detection;cancer diagnosis;cancer genome;Cancer Model;Canis familiaris;cell free DNA;Cells;Characteristics;circulating DNA;Circulation;Clinical;clinical decision-making;clinical diagnostics;Combined Modality Therapy;Complex;Copy Number Polymorphism;Data;data integration;Data Set;design;Detection;Development;Diagnosis;differential expression;Disease;Disease Progression;DNA;DNA Methylation;DNA methylation profiling;Drug Exposure;Drug resistance;Early Diagnosis;Early identification;Early Intervention;Enrollment;Epigenetic Process;Evaluation;Ewings sarcoma;Excision;experience;FDA approved;Gene Expression;Gene Expression Alteration;Gene Expression Profile;Genes;Genome;genome sequencing;Genomics;Goals;Histologic;Human;human model;Image;immunoregulation;implementation facilitation;improved;Incidence;Individual;individualized medicine;liquid biopsy;lung metastatic;Machine Learning;machine learning algorithm;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Methodology;Methods;Methylation;methylation pattern;molecular marker;Monitor;MPP2 gene;Mutation;Nature;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;novel;Osteosarcoma;Outcome;Patient Care;Patients;Pattern;Plasma;Primary Neoplasm;Prior Therapy;prospective;Prospective Studies;rapid detection;Recurrence;Regimen;Relapse;Resistance;response;Rhabdomyosarcoma;RNA;Sampling;Sarcoma;Scientist;Sensitivity and Specificity;skills;Somatic Mutation;Techniques;Testing;Therapeutic;therapy resistant;Time;Tissues;tool;Transcript;transcriptome sequencing;transcriptomics;translational medicine;treatment optimization;Treatment Protocols;treatment response;tumor;Tumor Burden;tumor DNA;tumor microenvironment;Tumor Tissue;Variant;whole genome;Work

PROJECT_TITLE: Optimizing blood biopsy in cancers with low mutation burden and high structural complexity


NIH_SPENDING_CATS: Bioengineering;Contraception/Reproduction;Infertility;Networking and Information Technology R&D (NITRD);Women's Health Research

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative Mechanistic understanding of developmental abnormalities and fertility defects can be greatly assisted by computational models of dynamics in animal eggs and early embryos. The proposed work will establish broadly applicable tools for data-driven computational modeling of critical processes in oocyte development and primordial germ cell formation.

PI_NAMEs: SHVARTSMAN, STANISLAV Y. (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 3-Dimensional;Active Biological Transport;Address;Animals;Biology;biophysical model;Cell Count;Cell Cycle Arrest;Cell Lineage;Cells;Clinical;Computer Models;computer studies;computerized tools;Coupling;Cytoplasm;Cytoplasmic streaming;Cytoskeleton;Data;data tools;Deposition;design;Development;Diffusion;Drosophila genus;egg;Embryo;Embryonic Development;End Point Assay;Experimental Models;experimental study;Fertility;Fertility Disorders;Filament;fluid flow;Funding;Future;Gametogenesis;Genetic;Genetic Models;Genetic Transcription;Germ;Germ Cells;Germ Lines;Growth;Human;hydrodynamic flow;Image;image processing;imaging study;insight;Interdisciplinary Study;Joints;Kinesin;Mediating;Microtubules;Mitotic;model organism;Modeling;Motor;Nature;Oocytes;Oogenesis;Process;Proteins;Regulation;Relaxation;Reproduction;Reproductive Biology;Research;Research Personnel;Research Support;Resources;scientific computing;Signal Transduction;Somatic Cell;Speed;statistics;Structure of primordial sex cell;Study models;Supporting Cell;System;Testing;Theoretical Studies;theories;Training;tumor;Walking;Work

PROJECT_TITLE: Collective dynamics in cell clusters

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ORG_CITY: ATLANTA

ORG_DEPT: SURGERY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative This study will contribute to public health by determining if the apolipoprotein L1 (called APOL1) genotype of kidney donors impacts the function and survival of transplanted kidneys. Results of this study may also allow the quality of kidneys from deceased organ donors to be more accurately assessed which in turn will aid transplant professionals and patients in making decisions about whether or not to accept a given kidney. This study will also determine whether the APOL1 genotype of otherwise healthy African Americans influences their future health and kidney function.

PI_NAMEs: NEWELL, KENNETH A.;PASTAN, STEPHEN  (contact)

PROJECT_TERMS: Acceleration;Acute;Address;African American;African American population;African ancestry;Albumins;Allografting;American;Antibodies;Apolipoproteins;Award;Bacterial Infections;Biopsy;Blood;Caring;Child health care;Clinical;clinical center;Clinical Data;cohort;Collection;Consent;Cost Savings;Counseling;Creatinine;Data;Decision Making;digital pathology;Disparity;DNA;Donor person;Education;End stage renal failure;Enrollment;Ensure;Environmental Risk Factor;ethnic difference;European;Evaluation;Face;Failure;follow-up;Future;gene interaction;Genes;Genetic;genetic risk factor;genetic variant;Genotype;Geography;graft failure;Graft Survival;Health;Health Care Costs;high risk;HLA Antigens;Hospitals;Immunosuppression;improved;Individual;Kidney;kidney biopsy;Kidney Failure;Kidney Transplantation;Lesion;Living Donors;living kidney donor;Longterm Follow-up;Measurement;Measures;Medical;Medical center;medical schools;novel;Observational Study;Organ;Organ Donor;Outcome;Outcome Study;Participant;Patients;Pattern;Phase;Phenotype;Policies;post-transplant;Prevalence;primary outcome;programs;prospective;Proteinuria;Public Health;Quality of life;racial difference;recruit;Recurrent disease;Registries;Renal function;Reporting;repository;Research;Risk;risk variant;Role;Safety;Sampling;secondary outcome;Serum;Site;Slide;Specific qualifier value;Specimen;Texas;Time;transplant centers;Transplant Recipients;Transplantation;United Network for Organ Sharing;United States National Institutes of Health;Universities;Urine;Variant;Virus Diseases;Waiting Lists

PROJECT_TITLE: 8/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center


NIH_SPENDING_CATS: Clinical Research;Data Science;Digestive Diseases;Genetics;Hematology;Human Genome;Infant Mortality;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Microbiome;Neonatal Respiratory Distress;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Sepsis

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as prematurity is a major problem globally and the results of this research have the potential to improve preterm survival and decrease morbidity. We propose to predict survival and morbidity, reliably and early in preterm infants using clinical and multi-omics data, which will enable us to intervene early, improve survival and decrease complications of prematurity (targeted precision medicine).

PI_NAMEs: PAMMI, MOHAN  (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Adolescent;Age;Artificial Intelligence;Bioinformatics;Biological Markers;biomarker discovery;Blood specimen;Bronchopulmonary Dysplasia;Child;Clinical;Clinical Data;clinical predictive model;cohort;Collaborations;Collection;college;Data Set;Databases;Digestive System Disorders;disability;Disease;dysbiosis;Early Intervention;Enrollment;Feces;Functional disorder;Future;Genetic Transcription;Goals;Health;high risk;Histone Deacetylation;host microbiome;Immunity;improved;Infant;Inflammation;innovation;Intervention;intraventricular hemorrhage;Knowledge;knowledge base;knowledgebase;late onset sepsis;Life;Machine Learning;Mediating;medical schools;Medicine;Metabolic;Metabolic Pathway;Metabolism;metabolome;microbial;microbial disease;microbiome;Mission;Modeling;Monitor;Morbidity - disease rate;mortality;Multiomic Data;multiple omics;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;Necrotizing Enterocolitis;Neonatal;Neonatology;novel;Outcome;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Pediatric Hospitals;precision medicine;predictive marker;predictive modeling;premature;Premature Infant;prognostication;prospective;Prospective cohort;Prospective Studies;Public Health;Research;Research Design;Retinopathy of Prematurity;Retrospective cohort;Sampling;Science;Sepsis;survival prediction;Survivors;Techniques;Testing;Texas;tool;Traditional Medicine;United States National Institutes of Health;Universities;Urine;Validation;Vermont;Very Low Birth Weight Infant;Volatile Fatty Acids

PROJECT_TITLE: Machine Learning and Multiomics for Predictive Models and Biomarker Discovery in Preterm Infants.

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE / RELEVANCE Children’s exposure to intimate partner violence (IPV), often perpetrated by fathers, poses serious risk to children, including child maltreatment and mental health impairment. Lacking are interventions that address the complex nature of IPV, including fatherhood and coparenting. The proposed project will compare Fathers for Change, a novel intervention for fathers with IPV, to an active control with a randomized sample of child welfare referred fathers of 4- to 7-year-olds to grow the F4C evidence-base, and advance knowledge of therapeutic mechanisms through which F4C exerts its effects.

PI_NAMEs: GRASSO, DAMION JOSEPH;STOVER, CARLA S (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: 7 year old;active control;Address;Affect;Aftercare;Aggressive behavior;associated symptom;Behavior;care systems;Caregivers;Child;Child Abuse and Neglect;Child Mental Health;child protective service;Child Rearing;Child Welfare;Code;Complex;Data;design;Development;Diagnostic Factor;effective intervention;efficacy evaluation;emotion regulation;Emotional;Emotions;evidence base;Exclusion;experience;Exposure to;Family;Family Violence;father child interaction;father role;Father-Child Relations;fatherhood;Fathers;Home;Impaired health;Impairment;improved;Intervention;intervention program;intimate partner violence;Knowledge;Masks;Mediating;men;Mental Health;Mental Health Associations;Meta-Analysis;Methods;Modeling;Motivation;multimodality;Nature;novel;Outcome;Parent-Child Relations;Parents;Patient Self-Report;physical abuse;pilot trial;Post-Traumatic Stress Disorders;Process;Psychopathology;psychosocial;Randomized;Randomized, Controlled Trials;Reaction;Recovery;Regulation;Research;Risk;Role;Sampling;Site;Source;Stress;Symptoms;Therapeutic;therapeutic target;Time;treatment effect;Violence;violence exposure;Work

PROJECT_TITLE: Examining Therapeutic Change Mechanisms in an Affect Regulation, Father-Focused Intervention for Reducing Family Violence and Associated Symptoms in Children

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;HIV/AIDS;Hematology;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Organ Transplantation;Pediatric;Pediatric Cancer;Rare Diseases;Transplantation

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE Post-transplant lymphoproliferative disease (PTLD) is a group of rare malignant complications of solid organ transplant that include Hodgkin disease and non-Hodgkin lymphoma. About 50-80% are associated with Epstein-Barr virus (EBV) infection, yet the T cell and Natural Killer cell immune responses in primary EBV infection in children or during progression to PTLD are not well characterized. By performing detailed prospective immunological phenotyping through the first year after 278 pediatric organ transplants, we will unearth pathways that may inform EBV oncogenesis progression in immunocompromised populations.

PI_NAMEs: DHARNIDHARKA, VIKAS R. (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Abdomen;Activities of Daily Living;Address;Adult;Allografting;Biological Assay;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;chemokine;Chest;Child;Childhood;Chronic;Clinical;co-infection;Communicable Diseases;Complication;cytokine;Data;Detection;Development;DNA;Elements;Epstein-Barr Virus Infections;Epstein-Barr Virus-Related Malignant Neoplasm;Evaluation;exhaust;exhaustion;experimental study;Exposure to;Flow Cytometry;Functional disorder;functional status;Generations;Goals;Heart;high risk;Hodgkin Disease;Human;Human Herpesvirus 4;Immune;immune function;Immune response;Immunocompetent;Immunocompromised Host;Immunologics;Immunology;Immunosuppression;Immunotherapy;Individual;Inflammatory;Intervention;Intestines;Kidney;Knowledge;Liver;Lung;Lymphoma;Lymphoproliferative Disorders;Malignant - descriptor;member;Memory;Natural Killer Cells;NK Cell Activation;Non-Hodgkin's Lymphoma;Normal Statistical Distribution;Nucleic Acid Amplification Tests;Oncology;organ transplant recipient;Organ Transplantation;Outcome;Pathway interactions;patient subsets;Patients;Pediatric Hospitals;peripheral blood;Phase;Phenotype;Plasma;Population;post-transplant;prevent;Primary Infection;programs;prospective;Prospective cohort;Publishing;receptor;Recovery;response;rituximab;Sampling;Solid;Standardization;T cell therapy;T memory cell;T-Lymphocyte;Time;translational approach;transplant centers;tumorigenesis;Viral;viral DNA;Viral load measurement;Viral Load result;Virus;Virus Replication;Whole Blood;young adult

PROJECT_TITLE: Understanding the immune response changes to clinical interventions for Epstein-Barr virus infection prior to lymphoma development in children after organ transplants (UNEARTH)


NIH_SPENDING_CATS: Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Pediatric;Rare Diseases

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Defects affecting tissues of the anterior segment lead to a group of highly debilitating eye disorders referred to as anterior segment dysgenesis (ASD), which represents one of the leading causes of congenital corneal opacity and congenital glaucoma. This study will elucidate signaling pathways required for proper anterior segment development in a complex group of diseases called ciliopathies. This knowledge could help identify and rationalize novel therapeutic targets for cilia-related disorders of the anterior segment, including ASD, congenital glaucoma, and myopia, and may also have wider implications for understanding complex morphogenetic events in other tissues.

PI_NAMEs: IOMINI, CARLO  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Ablation;Address;Adult;Affect;Anterior;Anterior segment dysgenesis;Cartilage;Cataract;cell behavior;Cells;Cilia;Ciliary Body;ciliopathy;Coloboma;Complex;computerized tools;Cornea;Corneal Opacity;Corneal Stroma;Cues;Defect;Development;Diagnosis;Disease;Drainage procedure;Embryo;Erinaceidae;Event;Eye;Eye Development;Eye diseases;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic;Glaucoma;Heterogeneity;Human;Hydrophthalmos;imaging approach;in vivo imaging;Iris;Joubert syndrome;Keratoconus;Knowledge;Lead;lens;Lesion;Link;malformation;Meckel-Gruber syndrome;Mediating;Mesenchyme;Molecular;Morphogenesis;mouse model;Mus;mutant;Mutation;Myopia;Neural Crest;Neural Crest Cell;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Outcome;Pathway interactions;Patients;Pharmacological Treatment;Phenotype;Play;Population;Proteins;Rationalization;repaired;Reporting;Role;Sclera;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Structure;Structure of retinal pigment epithelium;Testing;Tissue-Specific Gene Expression;Tissues;transcription factor;Trauma;Vision;Work

PROJECT_TITLE: Elucidating signaling networks in Anterior Segment development, repair and diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-F(02)M]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: ELLICOTT CITY

ORG_NAME: REMBAC ENVIRONMENTAL, LLC

PHR: PROJECT NARRATIVE Polychlorinated biphenyls (PCBs) dominate the ecological and human health risk associated with contaminated sediments in the United States and is a frequent cause of fish consumption advisories worldwide. Effective in situ treatments that can be rapidly deployed with minimal disruption in environmentally sensitive sites such as tidal marshes is a sustainable, minimally invasive and relatively low cost technology that is critically needed to help reduce the vast inventory of PCB contaminated sediments, particularly in former industrial areas that frequently impact underrepresented communities. The proposed research will advance towards commercialization a novel in-situ bioremediation technology that employs microbes and activated carbon to treat PCB impacted sediments at the New Bedford Harbor Superfund Site.

PI_NAMEs: AMOS, CRAIG BENNETT (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: Address;Aerobic;Amendment;Anaerobic Bacteria;Area;Bacteria;bioaccumulation;Biological Assay;Biological Availability;Bioreactors;Bioremediations;Carbon;Cell Count;Cells;Collaborations;commercialization;commercially viable technology;Communities;Complex;Consumption;contaminated sediment;cost;Cost Analysis;cost effective;cost effective treatment;Coupled;Data;dechlorination;density;Development;effectiveness analysis;effectiveness evaluation;efficacy evaluation;Engineering;Ensure;Environment;Environmental Impact;Equipment and supply inventories;Excision;field study;Fishes;Food Webs;Freeze Drying;fundamental research;Goals;Growth;Growth Factor;Habitats;Health;Human;improved;In Situ;Industrialization;innovation;interest;landfill;Legal patent;manufacturing scale-up;Methodology;Methods;Microbe;microbial;microorganism;minimally invasive;Monitor;Municipalities;National Research Council;novel;Oxidation-Reduction;Performance;Phase;pollutant;Polychlorinated Biphenyls;preservation;Privatization;Process;Production;receptor;remediation;Reporting;Reproducibility;Research;Research Personnel;restoration;Risk;scale up;Scientist;Shipping;Site;Small Business Innovation Research Grant;Sodium Chloride;Source;success;Superfund;superfund site;Surface;System;Techniques;Technology;Technology Transfer;Testing;Toxic effect;treatment site;United States;United States Environmental Protection Agency;Universities;Water

PROJECT_TITLE: Development of an innovative approach for in situ treatment of PCB impacted sediments by microbial bioremediation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-E(13)]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND STATE DEPT OF HEALTH

ORG_STATE: RI

PHR: Project Narrative Title: Rhode Island’s Maintenance of Human Food Rapid Response Team Funding Opportunity Number (FOA) : RFA-FD-23-019 This grant will support the efforts to maintain the Rhode Island Rapid Response Teams (RI RRT) to facilitate long-term improvements and innovation to the national integrated food safety system by unifying and coordinating federal/state/local human and animal food (HAF) emergency response efforts including: 1) Strengthening the link among epidemiology, lab and environmental health/regulatory components; 2) Improving States' regulatory and surveillance HAF protection programs to include using Incident Command System (ICS)/National Incident Management System (NIMS) principles and a Unified Command structure to conduct integrated responses to all-hazards HAF emergencies, rapidly identifying and removing tainted food from commerce, and conducting root cause investigations to inform future prevention efforts; and 3) Addressing supporting components, such as training, data sharing, data analysis, communications, continuous process improvement, and development of best practices and other resources to support national response capacity/capability development.

PI_NAMEs: VIVEIROS, BRENDALEE  (contact)

PROGRAM_OFFICER_NAME: ANDREWS, THANH

PROJECT_TITLE: Rhode Island Human Food Rapid Response Teams


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Machine Learning and Artificial Intelligence;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Exposure to environmental chemicals, such as phthalates and organophosphate flame retardants (OPFRs), during pregnancy can impact the developing fetal brain. Existing studies focus on the effects of isolated exposure to these compounds rather than the multiple exposures common in real-world settings, and we know very little about potential protective factors that can help like mothers’ prenatal nutrition and cognitively stimulating interactions between parents and young children. This study will be the first to examine several child neurobehavioral outcomes associated with combined exposure to phthalates and OPFRs, and the potential for maternal nutrition and parental cognitive stimulation to improve outcomes.

PI_NAMEs: COLLETT, BRENT RUSSELL;SATHYANARAYANA, SHEELA  (contact)

PROGRAM_OFFICER_NAME: LAESSIG, SUSAN ALISON

PROJECT_TERMS: Address;Affect;Attenuated;Brain;Chemicals;Child;Child Health;Childhood;Clinical;clinically significant;Cognitive;cognitive ability;cohort;Communities;community partnership;Consent;Data;Development;Diet;dietary;dietary guidelines;Disease;DNA Methylation;early childhood;Early identification;Environment;environmental chemical;Environmental Exposure;Epigenetic Process;Equilibrium;ethnic diversity;Exposure to;Family;fetal;fetal programming;Flame Retardants;Future;Geography;Goals;Government Agencies;Harm Reduction;Hispanic;Home environment;improved;improved outcome;Individual;Informal Social Control;innovation;Intervention;Life;low socioeconomic status;Machine Learning;machine learning model;Mediating;Mediator;Mentorship;Methods;Methylation;Mission;Molecular Target;mother nutrition;Mothers;multidisciplinary;neural network;neurobehavior;neurobehavioral;neurodevelopment;Neurologic;neurotoxic;neurotoxicity;Neurotoxins;novel;novel strategies;Organophosphates;Outcome;Oxidative Stress;Parents;Participant;Pathway interactions;Patient Recruitments;Phenotype;phthalates;Policies;Pregnancy;Pregnant Women;prenatal;prenatal environmental exposure;prenatal exposure;Prenatal Nutrition;prospective;protective factors;Protocols documentation;Publishing;Qualifying;racial diversity;recruit;Research;Research Personnel;Risk;Rural;Rural Community;Sampling;Science;Scientist;Site;Socioeconomic Status;Toxic effect;Umbilical Cord Blood;Underrepresented Minority;United States National Institutes of Health;Urban Community;Visit;Washington

PROJECT_TITLE: Mediators and Modifiers of Prenatal Environmental Exposures and Child Neurodevelopment: DNA methylation, Prenatal Diet, and Cognitive Stimulation (MEND)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]