NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: MOBILE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF SOUTH ALABAMA

PHR: PROJECT NARRATIVE Pseudomonas aeruginosa is an antibiotic resistant ESKAPE pathogen, and an etiological agent of nosocomial pneumonia, sepsis, and acute lung injury (ALI). Despite the severity and prevalence of these debilitating conditions, there are currently no specific therapies available to facilitate treatment and augment patient recovery. This proposal will test the transformative concept that the P. aeruginosa T3SS effector ExoU induces an indirect cell lysis pathway via activation of gasdermin D-mediated pyroptosis – this novel pathway represents a potential target for the development of therapeutics to treat pneumonia, sepsis, and ALI.

PI_NAMEs: AUDIA, JONATHON PETER (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Active Sites;Acute Lung Injury;adverse outcome;Antibiotic Resistance;Aspartate;Bacterial Toxins;Bypass;Calpain;CASP1 gene;Caspase;Cell Culture Techniques;Cell Death;cell injury;Cell model;cell type;Cells;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Combined Modality Therapy;Critical Illness;Cysteine;Cystic Fibrosis;Cytolysis;Cytoskeleton;cytotoxicity;Data;Endothelial Cells;Endothelium;Epithelial Cells;ESKAPE pathogens;Etiology;exoenzyme;experimental study;Functional disorder;gene-editing approach;Genes;Heart;Human;human old age (65+);immune cell infiltrate;Immunocompromised Host;inducible gene expression;Infection;Inflammasome;Inflammation;Inflammatory;innovation;Intensive Care Units;Intoxication;Knowledge;Lead;Lipopolysaccharides;Lung;lung injury;Macrophage;Mediating;Mediator;Membrane;Modeling;Morbidity - disease rate;mortality;Nosocomial pneumonia;novel;opportunistic pathogen;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Peptide Hydrolases;Permeability;pharmacologic;Phospholipase A2;Phospholipases A;Physiology;Pneumonia;pneumonia treatment;Positioning Attribute;Prevalence;Process;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pseudomonas aeruginosa pneumonia;Publications;Publishing;Recovery;Respiratory Failure;response;Role;Sepsis;Severities;Signal Transduction;targeted treatment;Technology;Testing;therapeutic development;Type III Secretion System Pathway;Ubiquitin;Virulence;Virulence Factors;Virulent;Work;World Health Organization

PROJECT_TITLE: The Pseudomonas aeruginosa virulence factor ExoU activates pyroptosis

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Vaccine Related

ORG_CITY: WORCESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: What Precursors Become Lung-Resident CD4 Memory that Protect Against Respiratory Infections or Cause Lung Pathology? Respiratory infections, which include the major SARS and influenza pandemics of the 21st century as well as yearly influenza outbreaks, are a leading cause of mortality and morbidity across the world. This grant will define the pathway of development of an immune T cell type known as CD4 TRM that become resident in the lung where they can rapidly protect against respiratory infections but may also cause lung damage, so we will explore their mechanisms of protection and damage. The results will give us new insights into how to develop vaccines that efficiently induce protection in the lung and treatments that minimize lung damage during an immune response to respiratory infection.

PI_NAMEs: DEVARAJAN, PRIYADHARSHINI  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: 2019-nCoV;Acute respiratory infection;adaptive immune response;Automobile Driving;B-Lymphocytes;Bacterial Infections;Bordetella pertussis;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;cell type;Cells;Cessation of life;Circulation;Compensation;COVID-19;COVID-19 patient;Cytolysis;cytotoxic;cytotoxicity;Data;design;Deterioration;Development;Disease Outbreaks;Down-Regulation;Epithelial Cells;experimental study;fighting;Future;Gene Expression Profile;Generations;Genetic Transcription;Grant;helminth infection;Human;Immune;Immune response;Immunity;immunopathology;Immunotherapeutic agent;Immunotherapy;Infection;Inflammation;Influenza;influenza infection;influenza outbreak;insight;Interleukin-15;Interleukin-2;Knowledge;Learning;Location;Longevity;Lung;Lung immune response;lung injury;Maintenance;Mediating;Memory;Memory Loss;MHC Class I Genes;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;mutant;Mutate;pandemic disease;pandemic influenza;pathogen;Pathogenicity;Pathologic;Pathology;Pathway interactions;Pattern;Phenotype;Play;Pneumococcal Pneumonia;Population;preservation;pressure;Prognosis;Proliferating;pulmonary function;Pulmonary Pathology;recruit;Respiratory distress;Respiratory physiology;Respiratory Tract Infections;respiratory virus;response;Risk;Role;SARS coronavirus;Severe Acute Respiratory Syndrome;Signal Transduction;Site;Structure of parenchyma of lung;T memory cell;T-Lymphocyte;therapy design;tissue resident memory T cell;Tissues;Tuberculosis;Vaccination;vaccine development;Vaccines;Viral;Viral Proteins;Virus Diseases

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Narrative The exacerbation of rising temperatures and urbanization poses an increased risk to vulnerable urban populations from heat exposure at night, as urban heat islands release heat slowly during summer nighttime. Although adaptation planning for high temperatures during the day has been developed and implemented at the city-wide or governmental levels, heat adaptation behaviors in individual households are less understood, particularly during nighttime hours. To gain insight into the combined effects of individual behaviors, built environment, and nighttime heat exposure on heat adaptation behavior in residential houses, we propose to (1) establish a Community Advisory Board, comprising local residents and academic researchers and (2) examine the collective impact of indoor home heat exposure, individual attributes, and built environment factors on individual-level heat adaptation behavior and provide guidance on effective heat adaptation strategies to community leaders and vulnerable residents.

PI_NAMEs: HAN, INKYU  (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Adaptive Behaviors;Affect;Age;Air;Air Conditioning;Award;Behavior;behavior influence;Behavioral;built environment;Characteristics;Cities;Climate;climate change;climate impact;Cognitive;Communities;community advisory board;community engaged approach;community organizations;Complex;data to knowledge;Decision Modeling;Devices;Disparity;Education;Elderly;Environmental Health;Environmental Risk Factor;European;evidence base;experience;Exposure to;extreme heat;Frequencies;Future;Goals;Green space;hazard;Health;health belief;Heat Exhaustion;heat island;Heat Waves;Helping Behavior;High temperature of physical object;Home;Hour;Household;human old age (65+);improved;Income;Individual;insight;Knowledge;Language;Low income;member;Modeling;Morbidity - disease rate;mortality;Motivation;National Institute of Environmental Health Sciences;Outcome;people of color;Philadelphia;Planning Theory;Population;Poverty;Predisposition;Preparation;promote resilience;Protocols documentation;Recommendation;recruit;Reporting;Research Personnel;Risk;risk perception;Role;Seasons;Severities;Sleep disturbances;social;Social Network;Stimulus;Stroke;Structure;Surface;Surveys;Temperature;theories;Translations;trend;urban area;Urban Community;Urban Population;urban underserved;Urbanization;Vulnerable Populations

PROJECT_TITLE: Adaptation to nighttime indoor heat exposure: the role of the built environment and behavioral factors

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Microbiome;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE The FAMiLI is a state-of-the-art nationwide cohort research infrastructure to serve as the platform to collaborate and implement innovative environmental epidemiology research, addressing health disparities for Asian Americans and immigrant health outcomes.

PI_NAMEs: AHN, JIYOUNG  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Acculturation;Address;Adult;aged;Air Pollution;Asia;Asian;Asian Americans;Asian ancestry;Behavioral;Big Data;biobank;Biological;Chinese;Chinese American;cohort;Cohort Studies;Collaborations;Collection;Communities;Community Participation;community partners;Country;Data;Data Collection;Data Element;Data Linkages;data management;Data Science;data sharing;Databases;Diet;Disparity;Enrollment;Environment;environmental change;Environmental Epidemiology;Environmental Health;Environmental Risk Factor;epidemiology study;equity, diversity, and inclusion;Ethnic Origin;experience;Feces;follow-up;Food;Fostering;Foundations;Generations;Goals;gut microbiome;Health;health disparity;Healthcare;human genomics;Immigrant;Immigration;improved;Incidence;Individual;innovation;insight;Investigation;Knowledge;Korean American;Koreans;Life Style;Maintenance;marginalized population;member;Metabolic Diseases;metabolomics;microbiome;migration;Monitor;National Institute of Environmental Health Sciences;Non-Insulin-Dependent Diabetes Mellitus;novel marker;oral microbiome;Outcome;Participant;participant enrollment;Predisposition;Preventive;prospective;Race;racial disparity;racial population;Recording of previous events;recruit;Research;Research Infrastructure;Research Personnel;Resources;Risk;risk prediction;Sampling;social culture;sociocultural determinant;socioeconomic diversity;socioeconomics;stool sample;Strategic Planning;Structural Racism;student mentoring;Surveys;Time;Training;Translating;Underserved Population;Update;validation studies;wearable device;wristband

PROJECT_TITLE: Maintenance and Enhancement of the Asian American enriched Cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LKB-D (U2)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: NARRATIVE - Enriching a Diverse Pregnancy Cohort from the San Francisco Bay Area to Expand Data Access and Individual Results Return on Environmental Exposures to Participant Communities We propose to enrich our existing Chemicals in our Body (CIOB) cohort of primarily Latina, White and Asian as well as Black mothers and children, by recruiting additional Black pregnant participants from Oakland, CA to improve our ability to address environmental contributors to health inequities. We will enhance the scope and methods of prenatal chemical measurements that integrate new neighborhood measures of structural racism and socioeconomic marginalization and facilitate analyses of multiple chemical and social stressor exposures on perinatal and maternal health. We will make our data available to the broader research community via an online repository, and report back individual-level chemical exposures to our participants to advance research, inform clinical practice, and elucidate opportunities for intervention and policy change to address the double jeopardy of environmental and social stressor exposures on maternal and perinatal health.

PI_NAMEs: MORELLO-FROSCH, RACHEL ADELE;PADULA, AMY MICHELLE;WOODRUFF, TRACEY J. (contact)

PROJECT_TERMS: 7 year old;9 year old;Address;adverse pregnancy outcome;Affect;Area;Aromatic Amines;Asian;Back;Behavior;biobank;Biological Specimen Banks;Black race;Blood;California;Cellular Phone;Chemical Exposure;Chemicals;Child;Child Health;clinical practice;cohort;Collaborations;Collection;Color;Communication;Communities;Complex;consumer product;Data;data access;data repository;data sharing;Dedications;demographics;Development;digital;Endocrine Disruptors;environmental chemical;environmental chemical exposure;Environmental Exposure;Environmental Health;Environmental Policy;environmental stressor;Equipment and supply inventories;Exposure to;Feedback;follow-up;Geography;Grant;health inequalities;health literacy;Health system;Hospitals;Illinois;improved;Income;Individual;Inequality;Infant Health;Intervention;Joints;Latina;Link;marginalization;Maternal and Child Health;Maternal Health;Measurement;Measures;Medical Records;Methods;Mothers;National Institute of Environmental Health Sciences;Neighborhoods;offspring;online repository;Outcome;Participant;Peer Review;Perinatal;perinatal health;Pesticides;phthalates;Plasticizers;Policies;Predisposition;Pregnancy;pregnant;prenatal;prenatal exposure;programs;psychosocial stressors;Publishing;recruit;Reporting;repository;Research;Research Personnel;safety net;Sampling;San Francisco;Scientific Advances and Accomplishments;Second Pregnancy Trimester;segregation;social;social media;Social Policies;social stressor;socioeconomics;Source;Spottings;Structural Racism;study population;Surveys;Techniques;Testing;Translating;United States National Institutes of Health;Universities;Urine;usability


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Cerebral Palsy;Clinical Research;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Physical Rehabilitation;Rehabilitation

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Public Health Impact The current proposal is relevant to public health because discovering the variation of real world post-surgical physical therapy frequency and intervention type and effects on meaningful gait outcomes in children with cerebral palsy (CP) after orthopedic multi-level surgery (MLS) will inform future work to determine the most effective strategies to improve health and motor outcomes for children with CP after MLS. Thus, the proposed R03 application is relevant to the NCMRR and NICHD mission to 1) improve child and adolescent health in the context of disability, 2) examine frequency and intensity of specific intervention types during a sensitive period of rehabilitation, 3) examine person centered real world outcomes, and 4) address the need for innovative methods in research design by harnessing the power of electronic health record data to determine real world application of treatments and outcomes.

PI_NAMEs: BAILES, AMY  (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Activities of Daily Living;Address;adolescent health;Ambulatory Surgical Procedures;Ankle;Automobile Driving;Body Weight;Caregivers;Caring;Cerebral Palsy;Child;Child Care;Child Health;Clinic;Clinical Data;clinical practice;Communities;Data;Deformity;design;Development;disability;Documentation;Dose;Electronic Health Record;evidence base;experience;fitness;foot;Frequencies;Future;Gait;gait rehabilitation;Goals;Health;Impairment;improved;innovation;interest;Intervention;intervention mapping;Knowledge;Level of Evidence;Link;Literature;Lower Extremity;Measures;Medical center;Methodology;Methods;Mission;Motor;National Institute of Child Health and Human Development;Operative Surgical Procedures;Orthopedics;Orthotic Devices;Outcome;Outpatients;Participant;Pediatric Hospitals;person centered;Physical therapy;Pilot Projects;Population;Procedures;programs;Public Health;Publishing;Quality of life;real world application;Recovery;recruit;Rehabilitation therapy;Reporting;Research;Research Design;Site;soft tissue;standard of care;Standardization;Study models;Surveys;Testing;Theoretical model;Therapeutic;Therapeutic Intervention;Training;treadmill training;treatment and outcome;treatment as usual;Variant;Visit;walking performance;walking speed;Work

PROJECT_TITLE: Capturing and characterizing the variability in physical therapy dose after orthopedic multi-level surgery in ambulatory children with Cerebral Palsy

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-H (02)]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Pediatric

ORG_CITY: Nashville

ORG_DEPT: PSYCHOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Secure attachment relationships set the foundation for later functioning, including social relationships, health, and well-being; yet, we know little about the daily contexts that foster attachment relationships between infants and those who care for them. Addressing the need for more ecologically-valid approaches to our understanding of children’s early caregiving experiences, this study uses the TotTag—a wearable device that can dynamically and unobtrusively measure patterns of physical proximity between children and caregivers continuously, regardless of location—to allow for assessments of time children spend in proximity to their caregiver in addition to caregiver sensitivity. The insights gained regarding the association between attachment security from two aspects of caregiving will help set the foundation for a better understanding of how caregiving behavior may promote attachment security.

PI_NAMEs: HUMPHREYS, KATHRYN LEIGH (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Address;Adverse effects;Age;base;Behavior;Birth;Caregivers;caregiving;Caring;Child;Collection;Coupled;Cross-Sectional Studies;Data;Data Collection;Dependence;Development;Devices;early experience;Emotional;Employment;Ethnic Origin;experience;Family;Family member;family structure;Fathers;Fostering;Foundations;Future;Health;Home;Home visitation;Hour;Housekeeping;infancy;Infant;innovation;insight;interest;Laboratories;late life;life span;Location;Measurement;Measures;Modeling;Morbidity - disease rate;mortality;Mothers;new technology;Outcome;Pattern;Personal Satisfaction;Play;primary caregiver;Procedures;programs;racial diversity;recruit;Research;Research Project Grants;research study;Risk;Role;Safety;Secure;Security;social;social relationships;socioeconomics;theories;Time;tool;Trauma;Trust;United States National Institutes of Health;wearable device;Work

PROJECT_TITLE: Caregiver–Child Proximity and Attachment Security

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Mutations in gene regulatory proteins during human development are a common cause of debilitating human disorders. The aim of this proposal is to implement a novel and highly tractable experimental platform to characterize the molecular functions of an understudied regulator of human peripheral nervous system development. Our work will yield novel insight into how molecular abnormalities that affect the nervous system arise and how they potentially can be reversed by targeted therapeutic interventions.

PI_NAMEs: STADTFELD, MATTHIAS  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Acute;Address;Affect;Alleles;Animal Model;Bioinformatics;Biological;Body System;candidate identification;Case Study;cell type;cellular pathology;Central Nervous System;Cephalic;Chromatin;chromatin immunoprecipitation;Chromatin Remodeling Factor;Clinical;Complex;Congenital Disorders;Custom;design;Development;directed differentiation;Disease;Distal;DNA Binding;dosage;Ectoderm;Embryo;Endocrine;Engineering;Enhancers;epigenomic profiling;Epitopes;experimental study;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;gene regulatory network;Genes;Genetic Engineering;Genetic Enhancer Element;genetic regulatory protein;Genetic Transcription;genomic locus;Goals;Health;Homeobox;hormone deficiency;Human;Human Development;human disease;human embryonic stem cell;Human Engineering;human pluripotent stem cell;Immunoprecipitation;in vivo;Influenza Hemagglutinin;insight;Knock-in Mouse;Knockout Mice;Label;Ligation;Literature;loss of function mutation;Microphthalmos;Modeling;Modification;Molecular;Molecular Abnormality;molecular pathology;Mutation;Nature;Nervous System;nervous system development;Nervous System Disorder;Neuroglia;Neurons;novel;Organ;Pathologic;Pathology;Patients;Pattern;Peripheral Nervous System;Phenotype;Physiological;Pituitary Hormones;Property;protein complex;Proteins;Proteomics;Publishing;RANK protein;Rare Diseases;Regulatory Element;Resolution;Retinal Dystrophy;Role;Sensory;Series;Specific qualifier value;targeted treatment;Technology;Therapeutic;therapeutic development;Therapeutic Intervention;Tissues;tool;transcription factor;Transgenic Organisms;Visualization;Work

PROJECT_TITLE: A transgenic toolbox to dissect molecular pathologies caused by OTX2 deficiency during ex vivo human ectoderm development

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-1 (01)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LARAMIE

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: Project Narrative A growing body of research shows that autism screening tools are not as accurate for identifying autism in Black and Hispanic children compared to White children. The current project uses rigorous methodologies to determine the sources of psychometric scoring inequities across Black, Hispanic, and White children on two popular autism screening tools, and quantify the impact on overall screener performance for Black and Hispanic children.

PI_NAMEs: MOODY, ERIC J (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: 4 year old;5 year old;Age;Algorithms;Assessment tool;autism spectrum disorder;autistic children;Awareness;Black Populations;Black race;California;Case/Control Studies;Child;Colorado;comparative;Data;Data Analyses;Development;Diagnosis;diagnostic accuracy;Dimensions;Disparity;Disparity population;Early identification;Early Intervention;Education;English Language;Epidemiology;Equity;ethnic difference;Ethnic Origin;Ethnic Population;Event;Factor Analysis;Family;Health Care Costs;health disparity;Hispanic;Hispanic Populations;improved;Income;Inequity;instrument;Intellectual functioning disability;Literature;Logistics;Low Prevalence;Maryland;Measurement;Measures;Methodology;Methods;multidisciplinary;North Carolina;Outcome;outcome disparities;Pennsylvania;Performance;Process;Psychometrics;Public Health;Publishing;Questionnaires;Race;racial difference;racial population;Research;Residual state;response;Risk Factors;Sampling;screening;Screening procedure;secondary analysis;Sensitivity and Specificity;sex;simulation;social;social communication;Social Development;Socioeconomic Status;Source;Specificity;Structure;systemic barrier;Testing;theories;tool;Translating;Variant;verbal

PROJECT_TITLE: The practical impact of inequitable item responding on the diagnostic accuracy of screening tools for identifying Black and Hispanic children with autism.

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Machine Learning and Artificial Intelligence;Skin Cancer

ORG_CITY: DURHAM

ORG_DEPT: CHEMISTRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative We propose to use a novel type of microscopy (pump-probe imaging) to image the aggressiveness (metastatic potential) in melanomas. This is important because the current diagnostic standard in humans has serious defects; for example, it misses many “thin lethal” cancers which are undertreated. Success will provide a simple method to improve patient outcome by identifying patients who were initially misdiagnosed as not having metastic cancer, and could significantly decrease treatment costs.

PI_NAMEs: WARREN, WARREN S (contact)

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: absorption;Adjuvant;Adjuvant Therapy;Adverse event;biobank;Biological;Biological Models;Biopsy;Caring;Cells;Chemicals;Classification;Clinical;clinically relevant;Complex;cost;Data;Defect;Dependence;design;Detection;Diagnosis;Diagnostic;diagnostic biomarker;diagnostic value;Disease Progression;disorder control;Disseminated Malignant Neoplasm;Environment;Excision;FDA approved;Foundations;Goals;Health Care Costs;Histopathology;Human;Image;imaging probe;improved;Incidence;Interruption;Laboratories;Lesion;Lesion by Stage;Machine Learning;machine learning algorithm;Malignant Neoplasms;Melanins;Melanoma;Melanoma Cell;Metastatic Melanoma;Methods;Microscope;Microscopy;Multi-Institutional Clinical Trial;Neoplasm Metastasis;next generation;Noise;Nonmetastatic;novel;Pathology;Patient observation;Patient-Focused Outcomes;Patients;performance tests;Persons;Physiologic pulse;Play;Population;Predictive Value;Primary Lesion;Probability;Protocols documentation;Publishing;Pump;quantitative imaging;Recurrence;Resolution;Role;Scheme;Sentinel Lymph Node Biopsy;side effect;Signal Transduction;Specificity;Staging;success;Technology;Testing;Thinness;Time;Toxic effect;Translations;Treatment Cost;Treatment-related toxicity;tumor;tumor diagnosis;Tumor stage;Visualization;Work

PROJECT_TITLE: Improving Accuracy of Next-Generation Microscopy for Early Stage Metastatic Melanoma Detection

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Project Narrative With the strong overlapping macromolecule signal and its low concentration, lactate measurement is subject to low reliability with existing techniques either on 3 T or 7 T. HOPE (Half-intensity with macrOmolecule- suPprEssion) is the short-TE proton MRS we developed to suppress macromolecule signal and achieve substantial improvement of lactate measurements with significant higher reliability and usable data rate. We propose to measure lactate and other metabolites (e.g. glutamate, glutathione) in brain regions of white matter, gray matter and CSF in first episode and chronic schizophrenia in order to better understand the dynamic progression of lactate abnormalities in schizophrenia.

PI_NAMEs: CHEN, XI  (contact);ONGUR, DOST

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Antipsychotic Agents;Astrocytes;Attention;Behavior assessment;Binding;Biochemistry;Bioenergetics;Biological Process;Biology;Bipolar Disorder;Brain;brain abnormalities;Brain region;brain tissue;Cell Respiration;Chronic Schizophrenia;Clinical;Clinical assessments;Cognition;cognitive function;cognitive task;Communities;comparison group;Data;Defect;Delusions;design;Development;Emotional;Energy Metabolism;Exclusion;experience;Extracellular Space;first episode psychosis;Glutamates;Glutathione;Glycolysis;gray matter;Hallucinations;Impaired cognition;Impairment;improved;insight;Link;macromolecule;Magnetic Resonance Spectroscopy;Measurement;Measures;memory consolidation;Metabolic;Methods;Mitochondria;motivational processes;Myelin;Neuroglia;neuronal cell body;Neurons;novel;Participant;Patients;Pharmaceutical Preparations;Phase;Play;Prefrontal Cortex;Protons;Reporting;Role;Scanning;Schizophrenia;Series;severe mental illness;Signal Transduction;Signaling Molecule;Symptoms;Synaptic Transmission;Techniques;Time;usability;Waste Products;white matter;Work

PROJECT_TITLE: Measuring brain lactate and other metabolites in schizophrenia at 3T using an enhanced MR spectroscopy approach

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative: Affinity enhanced pMHCII-4E reagents will be tried in proof of principle experiments to assess their therapeutic potentials in activating or deleting antigen specific CD4 T cells.

PI_NAMEs: DILEEPAN, THAMOTHARAMPILLAI  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Acute;acute infection;Address;Adjuvant;Affinity;Antibodies;antigen detection;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Autoimmunity;autoreactivity;Bacterial Infections;Binding;CD4 Positive T Lymphocytes;Cell Death;Cells;Chronic;Clinical;cytokine;Cytotoxic T-Lymphocytes;design;detection limit;Development;dimer;Directed Molecular Evolution;efficacy evaluation;Engineering;Epitope spreading;Epitopes;exhaustion;Experimental Autoimmune Encephalomyelitis;experimental study;Functional impairment;Goals;Histocompatibility Antigens Class II;IL17 gene;Immune response;Immunotherapy;improved;In Vitro;in vivo;Infection;innovation;Interferon Type II;Label;Link;magnetic beads;Mediating;Modeling;mouse model;Multiple Sclerosis;Mus;Mutation;new technology;novel;oligodendrocyte-myelin glycoprotein;pathogenic microbe;Pathway interactions;Peptide Receptor;Peptide/MHC Complex;Peptides;persistent bacterial infection;Play;Population;prevent;Proliferating;Protein Inhibition;Proteins;Reagent;receptor;recruit;response;Ribosomes;Salmonella;Source;Specificity;Streptavidin;Streptococcal Infections;Streptococcus pyogenes;T-Cell Receptor;T-Lymphocyte;targeted agent;Techniques;Technology;Testing;Therapeutic;Tumor Immunity;Vaccines

PROJECT_TITLE: Therapeutic potential of affinity enhanced pMHCII-4E reagents

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Fetal growth restriction raises the risk of stillbirth and neonatal death. Currently, no effective therapeutic strategies exist to prevent or treat fetal growth restriction due, in part, to an incomplete understanding of the mechanisms regulating uteroplacental blood flow and fetal growth. This project will accelerate our understanding of the role of circulating metabolites in the regulation of uteroplacental blood flow and, in turn, fetal growth.

PI_NAMEs: JULIAN, COLLEEN GLYDE (contact);LORCA, RAMON A

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Acceleration;Address;Adenosine;Affect;Agonist;Altitude;Arteries;Biometry;Biopsy;Birth Weight;Blood;Blood flow;Blood Vessels;Bolivia;Cardiometabolic Disease;Cesarean section;chorionic plate;Circulation;Code;cohort;Cohort Studies;Collaborations;Colorado;Data;Doppler Ultrasound;ecto-nucleotidase;Endothelium;Enzymes;experimental study;extracellular;fetal;Fetal Growth;Fetal Growth Retardation;Frequencies;Glucose;Growth;high reward;high risk;Hour;Human;Hypoxia;Incidence;indexing;Knowledge;life span;Linear Regressions;Mass Spectrum Analysis;Measures;Metabolism;metabolome;metabolomics;Methods;Molecular;Mus;Myography;Myometrial;Neonatal Mortality;Nerve;novel;novel therapeutics;Nucleotides;Oxygen;Pathologic;Pathway interactions;patient subsets;Perfusion;Perinatal mortality demographics;Physiological;Placenta;Plasma;Pregnancy;pregnant;Pregnant Women;prevent;Prevention therapy;protein expression;Protocols documentation;Purinoceptor;Recording of previous events;recruit;reduced uteroplacental blood flow;Regulation;Research;residence;Resistance;response;Risk;Role;Sample Size;Signal Pathway;Signal Transduction;Site;small molecule;Smooth Muscle;stillbirth;success;Testing;therapeutically effective;Time;Tissues;Ultrasonography;ultrasound;Umbilicus;Uterus;vasoconstriction;Vasodilation;Venous;Woman

PROJECT_TITLE: Novel roles of purinergic signaling for altitude-associated fetal growth restriction

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Pediatric;Prevention;Primary Health Care;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Parents can help protect their adolescent children from experiencing adolescent relationship abuse (ARA), especially through parental monitoring. Parents accompany adolescents to well-child visits; therefore, the pediatric primary care setting is an ideal location to deliver an ARA prevention intervention. In this proposal, we will create and pilot test an ARA prevention intervention for middle school age adolescents and their parents, which can be delivered by healthcare providers in pediatric primary care settings.

PI_NAMEs: RAGAVAN, MAYA  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Administrator;Adolescent;adolescent substance use;Age;Behavior;behavior change;Behavior Control;Behavioral;Behavioral Model;brief intervention;Caregivers;Centers for Disease Control and Prevention (U.S.);Child;Child Behavior;Childhood;Childhood Injury;Clinical;clinical research site;Communities;community intervention;Data;design;Development;Dimensions;Disclosure;Educational Assessment;Effectiveness of Interventions;effectiveness testing;effectiveness/implementation trial;Evaluation;evidence base;experience;Family;feasibility testing;feasibility trial;Foundations;Future;Goals;Health;Health Personnel;Healthcare;Home;human centered design;hybrid type 1 trial;Hybrids;implementation barriers;implementation facilitators;implementation outcomes;improved;interest;Interpersonal Relations;Intervention;intervention mapping;Interview;junior high school;Knowledge;Location;Longitudinal Studies;Mental Depression;Methods;Modeling;Motivation;multidisciplinary;National Institute of Child Health and Human Development;Needs Assessment;Outcome;Outcome Assessment;parent-adolescent communication;parental monitoring;Parents;Participant;pilot test;pilot trial;prevent;Prevention;Prevention strategy;preventive intervention;Primary Care;primary care clinic;primary care setting;primary outcome;Proctor framework;Production;programs;protective factors;Provider;psychologic;recruit;relationship abuse;Resources;response;retention rate;satisfaction;school based health center;School-Age Population;secondary outcome;Self Efficacy;Sexual abuse;Sexual Health;Site;Strategic Planning;Surveys;systematic review;Teenagers;Testing;theories;therapy design;therapy development;Time;tool;Translating;Trauma;treatment strategy;Victimization;Violence;violence prevention;Well Child Visits;wellness visit;Work;Youth

PROJECT_TITLE: Developing a parent-adolescent relationship abuse prevention intervention for pediatric primary care


NIH_SPENDING_CATS: Infectious Diseases;Prevention

ORG_DEPT: SURGERY

PHR: There is a paramount need for clinician scientists who are skilled in modern scientific methods and have the background to develop novel approaches to the diagnosis, treatment, and prevention of infectious, immunologic, and allergic diseases in children and adults. The Duke NIAID Scientist-Clinician-Investigator Stimulating access to Research in Residency (Duke NIAID SCI-StARR) Program will continue the successful approach of providing dedicated research time and training to Resident-Investigators from the Departments of Medicine, Pediatrics, and Surgery to foster their maturation into independent physician-scientists who use cutting-edge methods of laboratory and clinical research to pursue long-term academic careers investigating important issues related to human health. Project Narrative Page 7

PI_NAMEs: GREENBERG, RACHEL G;HARPOLE, DAVID H. (contact);PALMER, SCOTT M

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Achievement;Address;Adult;Affect;Allergic Disease;Applications Grants;Area;Autoimmunity;Award;Basic Science;Biomedical Research;Board Certification;career;career development;Caring;Child;Clinic;Clinical;Clinical Research;clinical training;clinical translation;Clinical Trials;Communicable Diseases;Communication;Communities;Country;Critiques;Dedications;Development;Development Plans;Diagnosis;Diagnostic;Doctor of Philosophy;Drug Kinetics;early phase clinical trial;Education;Educational workshop;Eligibility Determination;Ensure;Evaluation;experience;Extramural Activities;Faculty;Fellowship;Fostering;Foundations;Functional disorder;Funding;Goals;Grant;Health;Healthcare;Human;Hypersensitivity;Immune response;Immune System Diseases;Immunology;Immunosuppression;improved;Individual;Infection prevention;Infrastructure;innovation;Institution;Investments;Journals;Laboratory Research;Leadership;Life Cycle Stages;Manuscripts;Medical;medical schools;Medicine;meetings;Mentors;Mentorship;Methods;Mission;Modality;Modernization;multidisciplinary;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;next generation;novel strategies;Operative Surgical Procedures;Outcome;patient oriented;Pediatrics;Peer Review;Phase;Physicians;Physicians' Offices;Positioning Attribute;preference;prevent;Prevention;Productivity;programs;Public Health;Recording of previous events;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;Research Training;Residencies;Resources;response;Scholarship;Scientist;Signal Transduction;skills;Societies;Structure;Study Section;success;Therapeutic;Time;tool;Training;Training Programs;Translational Research;Transplantation;United States National Institutes of Health;Universities;vaccine development;Work;Writing

PROJECT_TITLE: Stimulating Access to Research in Residency (StARR) - NIAID

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 RCU-Z (S1)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Mental Health;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: LAS VEGAS

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: PROJECT NARRATIVE Although shift workers, particularly those who work at night, are at a higher risk of severe cognitive impairment such as Alzheimer’s disease (AD), we do not have a biomarker sensitive enough to reflect the level of adaptation to shift work and predict the risk of future cognitive impairment. The proposed study aims to examine the feasibility of establishing a cohort of active and retired shift workers and generate preliminary data on whether objective sleep quality measures and/or epigenetic changes in circadian genes are associated with variation in symptoms related to shift work tolerance and cognitive function. Research findings will significantly impact public health by informing personalized, optimized biobehavioral strategies to prevent AD in the early stage of life.

PI_NAMEs: KIM, JINYOUNG  (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: actigraphy;Age;aged;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;ARNTL gene;biobehavior;Biological Markers;biomarker identification;Blood;Blood Tests;Brain;circadian;Circadian Dysregulation;Circadian Rhythms;Cities;Cognitive;cognitive function;cohort;Collection;Data;Demographic Factors;Diagnosis;Disease Marker;DNA Methylation;Drowsiness;Electroencephalography;Epigenetic Process;experience;Fatigue;Functional disorder;Future;Genes;Glial Fibrillary Acidic Protein;Goals;Grant;high risk;Home;Hour;human old age (65+);Impaired cognition;Incidence;indexing;Individual;Individual Differences;inflammatory marker;innovation;Intervention;Investigation;Life;lifestyle factors;Link;Malignant Neoplasms;Measures;Mediating;Medical;Melatonin;Mental disorders;Methylation;mild cognitive impairment;neurotoxic;Odds Ratio;Older Population;Onset of illness;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Physiological;Plasma;Play;poor sleep;pre-clinical;pre-clinical assessment;prevent;Procedures;programs;prospective;Prospective Studies;Public Health;Recording of previous events;recruit;Research;resilience;response;Risk;Risk Factors;risk prediction;Role;Schedule;shift work;Shift-Work Sleep Disorder;Signal Transduction;Site;Sleep;Sleep Disorders;Sleep disturbances;sleep onset;sleep pattern;sleep quality;Sleeplessness;Slow-Wave Sleep;Solid;Surveys;Symptoms;Testing;Time;Urine;Variant;Wakefulness;Waste Products;Work;young adult

PROJECT_TITLE: Sleep depth and circadian genes as potential markers to reflect symptom variation and early risk of Alzheimer's disease in shift workers

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Health Services

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Patient activation, cognition, and self-management for LVADs Left-ventricular assist devices (LVADs) are the most complex machines ever designed for home use with difficult self-management (SM) and high health care use (HCU) but little is known about the factors influencing patient outcomes. Patient activation (PA) is the willingness and ability to manage a health condition and may offer unique opportunities for improving LVAD SM and HCU. We seek to understand the relationships between cognition, PA, LVAD SM, and HCU, and to explore PA as a mediator of the influence of cognition on outcomes, by studying patients prior to and within 12-months after LVAD surgery.

PI_NAMEs: CASIDA, JESUS ;PAVOL, MARYKATHRYN A (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Address;Adherence;Affect;Anticoagulation;Attention;blood pump;Caregivers;Caring;Cessation of life;Characteristics;Chronic;Chronic Care;Chronic Disease;Clinical Research;Cognition;Cognitive;cognitive skill;combat;comorbidity;Complex;cost;Dependence;design;Destinations;Devices;Diagnosis;emotional distress;Ethnic Origin;Explosion;Future;Gastrointestinal Hemorrhage;gender diverse;Goals;Health;Health Care Costs;health care service utilization;health literacy;Healthcare;Heart;Heart failure;Heart Transplantation;Heart-Assist Devices;Hemorrhage;Home;Hospitalization;Hospitals;Impaired cognition;Implant;implantable device;implantation;improved;improved outcome;Infection;infection risk;innovation;insight;Interdisciplinary Study;Intervention;Intervention Trial;Investigation;Knowledge;left ventricular assist device;Life;Managed Care;Mediating;Mediator;Medical;medical complication;Modeling;novel;Operative Surgical Procedures;Outcome;Patient Selection;Patient-Focused Outcomes;Patients;Persons;Physiological;Psychosocial Factor;Quality of life;Race;Reporting;Research;Sample Size;Sampling;Science;Self Care;Self Efficacy;Self Management;Site;Stroke;System;Telephone;Time;time use;Transplantation;Vulnerable Populations;willingness

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Lung;Methamphetamine;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Relevance to Public Health. Opioid and methamphetamine drugs are responsible for an ever increasing number of drug overdose deaths in the United States. Our studies will provide a better understanding of how and why these drugs cause illness and death; and, in the long- term, may lead to improved therapies for preventing and treating overdose.

PI_NAMEs: COTTEN, JOSEPH F (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Adrenergic Agents;Adult;Aftercare;analog;Animals;Autopsy;Blood Gas Analysis;Breathing;Cause of Death;Cessation of life;Clinical;Conscious;Dexmedetomidine;Dose;Dryness;Electromyography;Female;Fentanyl;Gastrocnemius Muscle;genioglossus muscle;glottis;Histopathology;improved;Intubation;Legal patent;Lung;lung pressure;male;Medical;Metabolic;Methamphetamine;methamphetamine effect;Methodology;Morphine;Muscle Rigidity;Naloxone;Nature;Nose;Opiate Addiction;Opioid;Overdose;overdose death;Pharmaceutical Preparations;Plethysmography;prevent;Public Health;Pulmonary Edema;Pulse Oximetry;Rattus;receptor;Skeletal Muscle;Stimulant;Sufentanil;synthetic opioid;Testing;Toxic effect;United States;Ventilatory Depression;vocal cord;Weight

PROJECT_TITLE: Airway compromise and skeletal muscle rigidity as toxicity contributors in synthetic opioid and methamphetamine co-administered rats

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Autoimmune Disease;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative This research addresses neuromyelitis optica spectrum disorder (NMOSD), a disabling autoimmune neurological illness that can result in blindness and paralysis. The purpose of the research is to develop an improved animal model suitable to test new therapies for NMOSD. Successful completion of this research project is expected to make a positive impact by contributing to the discovery of a cure for NMOSD.

PI_NAMEs: OH, UNSONG  (contact)

PROJECT_TERMS: Ablation;Address;adeno-associated viral vector;Adoptive Transfer;Animal Model;animal model development;Animals;Antigen Targeting;antigen test;Antigens;aquaporin 4;Autoantigens;Autoimmune;Autoimmunity;barrier to testing;Blindness;Confounding Factors (Epidemiology);Dependovirus;Development;Disabling;Disease;Dose;Enterobacteria phage P1 Cre recombinase;Functional disorder;Glial Fibrillary Acidic Protein;Immune response;Immune Tolerance;Immunization;Immunoglobulin G;improved;Infection;innovation;Knockout Mice;Knowledge;LacZ Genes;Mediating;Methods;Modeling;Mus;Neurologic;Neuromyelitis Optica;novel therapeutics;Paralysed;Pathogenicity;Pathology;preclinical study;Preclinical Testing;Predisposition;Prognosis;promoter;relapse prevention;Research;Research Project Grants;Risk;Scheme;seropositive;System;Tamoxifen;Testing;tool;Wild Type Mouse

PROJECT_TITLE: An animal model of anti-AQP4 autoimmunity

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health;Substance Misuse

PHR: PROJECT NARRATIVE While people required to register as sex offenders (PRR) under sex offender registration and notification (SORN) policies struggle with substance use at higher rates than the general population and have limited access to substance use treatment and other social services, no research has explored or addressed how the SORN policy context influences individual and macro-level substance use risk environments. This study will qualitatively explore how SORN policies influence PRR experiences with substance use, risk of substance use related harms, and access to treatment and harm reduction services, from the perspectives of PRR and stakeholders. Results from this proposed research will inform important future multi-level interventions that address policy and social determinants of substance use and co-occurring health issues for PRR.

PI_NAMEs: SHEFNER, RUTH  (contact)

PROGRAM_OFFICER_NAME: MULFORD, CARRIE FRIED

PROJECT_TERMS: Address;Advisory Committees;alcohol use disorder;Area;Award;Behavioral;black men;Black race;career;Caring;Case Manager;Categories;Charge;Cities;Collaborations;Communities;contextual factors;convict;Data;design;Diagnosis;Disadvantaged;Discrimination;Disparity;Drug Use Disorder;Economics;Educational Status;Eligibility Determination;Environment;Exclusion;experience;Exposure to;Face;Feedback;Foundations;Future;General Population;Goals;Growth;harassment;Harm Reduction;Health;Health Personnel;Health Sciences;Health Services Accessibility;high risk population;Home;Housing;housing instability;improved;Individual;Inpatients;Intervention;Interview;Investigation;Knowledge;Laws;Lawyers;Legal;Legal system;Literature;Lived experience;male;marginalization;men;Mental Health;Mentorship;National Institute of Drug Abuse;Neighborhoods;Notification;offender;Pattern;Persons;Philadelphia;Police;Policies;Population;probation;Procedures;programs;Provider;psychosocial;Public Health;Publishing;Punishment;Qualitative Methods;recruit;Reduce health disparities;reduced substance use;Reporting;Research;Research Personnel;Research Project Grants;Residencies;Resources;Risk;Safety;Schools;Services;sex;sexual predators;Shapes;social;social determinants;Social Environment;Social Network;Social Sciences;social stigma;Social Work;Stigmatization;structural determinants;Structure;Subgroup;substance use;Substance Use Disorder;substance use treatment;theories;Therapeutic;Unemployment;Vocational Education;Work

PROJECT_TITLE: Policy determinants of substance use and treatment access for individuals registered as sex offenders in Philadelphia: a Qualitative investigation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


ADMINISTERING_IC: OH

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative No studies have taken a systematic mechanistic approach to investigate how occupational exposure to tungsten affects the heart or cardiovascular disease risk factors, despite compelling epidemiological data linking tungsten exposure to increased cardiovascular disease risk. This project will investigate the effects of inhaled tungsten particulates on NRLP3 inflammasome activation of IL-1β signaling pathways, leading to cardiac remodeling and cardiovascular disease development. Discoveries from these studies with impact Research to Practice initiatives to inform identification of at-risk occupational populations, development of monitoring programs, and identification of effective counter measures to block immune fibroblast crosstalk, which could mitigate cardiovascular disease risk.

PI_NAMEs: BOLT, ALICIA M. (contact)

PROGRAM_OFFICER_NAME: GARRETT, BRIDGETTE E

PROJECT_TITLE: Defining the Role of IL-1? in Tungsten-Mediated Cardiovascular Disease

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Evidence suggests, that endosomal microautophagy (eMi), a protein degradation pathway distinct from macro- and chaperone mediated autophagy, is impaired in Alzheimer’s disease. In the proposed experiments we will determine the impact of pathological tau on mitochondrial function and on various microautophagy pathway proteins. Further, we will directly stimulate eMi to determine if it can prevent or rescue tau induced dysfunction in vivo.

PI_NAMEs: CONGDON, ERIN  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Affect;Age;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Animal Model;Animals;Area;ATP phosphohydrolase;Autophagocytosis;Binding;Biological Assay;Brain;Calcium;Calcium Signaling;Carrier Proteins;Cells;Charge;combat;Complex;Data;Degradation Pathway;Development;Digestion;endosome membrane;Endosomes;Ensure;examination questions;experimental study;Exposure to;Feedback;Functional disorder;Future;Health;Heat-Shock Response;Human;human data;Image;Impairment;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;inhibitor;Intervention;Link;live cell imaging;Measures;Mediating;Microscopy;Mitochondria;Modeling;Molecular Chaperones;Monitor;Multivesicular Body;Mus;mutant;Mutate;Mutation;Neurodegenerative Disorders;Neurons;neurotransmission;new therapeutic target;overexpression;Pathologic;Pathology;Pathway interactions;Patients;Play;prevent;Process;Production;protein degradation;protein expression;Proteins;Public Health;Publishing;Quality Control;Reporting;Research;Role;Signal Induction;Sorting;Synaptic Transmission;System;tau aggregation;tau mutation;tau Proteins;Tauopathies;Testing;therapeutic evaluation;Therapeutic Intervention;two-photon;Vacuolar Protein Sorting;Western Blotting;Wild Type Mouse;Work

PROJECT_TITLE: Disruption of Endosomal Microautophagy by Pathological Tau Protein

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Burden of Illness;Clinical Research;Digestive Diseases;Health Services;Infectious Diseases;Neurosciences;Prevention;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Neurocysticercosis (NCC) causes significant disability in regions of the world where populations are exposed to pigs and is increasingly reported, albeit typically at advanced stage, in the United States. No guidelines for early detection of NCC exist. This research will contribute to the fundamental knowledge of NCC prevalence in an at-risk US population (the household contacts of NCC patients) and identify an effective NCC screening approach that will detect and prevent future NCC cases, thereby reducing disability due to NCC.

PI_NAMEs: CLARK, EVA H (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: active method;Algorithms;Area;Biological Assay;Biological Markers;Biological Testing;Blood;Blood specimen;Body System;Brain;Brain imaging;Chronic;Clinical;Communities;Consensus;Consumption;cost;cost effective;Country;County;Cyst;Cysticercosis;Data;Detection;Development;Diagnosis;disability;disability-adjusted life years;Disease;Early Diagnosis;Early treatment;egg;Eligibility Determination;Embryo;Enrollment;Epidemiology;Epilepsy;Exposure to;Family suidae;Feces;Focal Neurologic Deficits;Frequencies;Future;gastrointestinal symptom;Goals;Guidelines;hatching;Head;Headache;Health system;Healthcare Systems;Household;Household and Family;Human;Immigration;improved;Income;indexing;Individual;Infection;Ingestion;innovation;Intestinal Diseases;Intestines;Knowledge;Laboratories;Larva;low and middle-income countries;Magnetic Resonance Imaging;member;metropolitan;Microscopy;migration;Molecular;Monitor;Morbidity - disease rate;national surveillance;Neurocysticercosis;neuroimaging;Neurologic;Oral;Ovum;Parasites;Participant;Patients;Performance;Persons;Peruvian;Pilot Projects;Population;Populations at Risk;Prevalence;prevent;Protocols documentation;Provider;Public Health;Questionnaires;recruit;Reporting;Research;research clinical testing;Research Project Grants;Research Proposals;Risk;Route;safety net;Sanitation;screening;screening guidelines;Screening procedure;Seizures;Serology;Specimen;stool sample;surveillance study;Symptoms;Taenia solium;Teniasis;Testing;Texas;Tissues;transmission process;United States;United States National Institutes of Health;Urine;Validation;X-Ray Computed Tomography

PROJECT_TITLE: EVALUATING NEUROCYSTICERCOSIS SCREENING PRACTICES AND EPIDEMIOLOGY.

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PHR: Project Narrative Due to the rapid nature of innovation in cancer research, challenges exist in training and retaining physician- scientists conducting rigorous translational research. The Columbia Cancer Research Training Program for Resident-Investigators (CAPRI) addresses the critical shortage of well-trained cancer physicians from multiple disciplines. The continuation of CAPRI, which provides comprehensive research training, will ensure a cadre of future clinical investigators who will conduct high-impact research spanning the cancer care continuum.

PI_NAMEs: CREW, KATHERINE D (contact);KACHNIC, LISA A.

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Acceleration;Address;Admission activity;anti-cancer research;Area;Basic Science;Biological;Biomedical Research;cancer care;Cancer Center;cancer clinical trial;cancer health disparity;cancer research center director;career;career development;Catchment Area;Clinical;clinical care;clinical development;Clinical Investigator;Clinical Sciences;Collaborations;Communities;Continuity of Patient Care;Dedications;Department chair;design;Development;Diagnosis;Discipline;Disease;Doctor of Philosophy;Education;Ensure;Environment;Ethnic Origin;Faculty;Fellowship;Fellowship Program;Fostering;Funding;Future;Gifts;Goals;Health;health equity;Health Promotion;Herbert Irving Comprehensive Cancer Center;Human;improved;innovation;Institution;interest;investigator training;Leadership;Letters;Malignant Neoplasms;Medical center;medical specialties;Medicine;member;Mentors;Morbidity - disease rate;mortality;multidisciplinary;National Cancer Institute;Nature;NCI Center for Cancer Research;New York City;next generation;Oncology;Operative Surgical Procedures;Outcome;Palliative Care;Participant;Pathology;Pathway interactions;patient population;Pediatrics;peer;Physicians;Population;Population Sciences;Positioning Attribute;post-doctoral training;pre-clinical;precision medicine;Prevention;programs;prospective;Race;Radiation Oncology;recruit;Reduce health disparities;Research;Research Personnel;Research Project Grants;Research Training;Residencies;Resources;response;Science;Scientist;screening;skills;socioeconomics;Supervision;survivorship;symposium;Technology;Training;Training and Education;training opportunity;Training Programs;Translating;Translational Research;translational scientist;tumor;Underrepresented Minority;United States National Institutes of Health;Universities

PROJECT_TITLE: CAPRI: Columbia Cancer Research Training Program for Resident-Investigators

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-Z (O1)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE  Though, several studies including our own have demonstrated that RNAs are targeted to synapses and that these RNAs play a critical role in memory storage, we do not know much about RNAs localized to specific synapses in vivo. In this proposal, by characterizing RNAs associated with a GFP tagged molecular motor protein KIF5C, we will isolate and characterize KIF5C targeted RNAs in ventral hippocampus-medial prefrontal cortical and ventral hippocampus-basolateral amygdala synapses. Successful completion of these studies will assess whether populations of RNAs become selectively enriched in specific synapses in vivo and their significance in the consolidation of contextual fear memory.

PI_NAMEs: PUTHANVEETTIL, SATHYA  (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Address;Affinity Chromatography;Amygdaloid structure;Anatomy;Animals;Aplysia;Applications Grants;Area;Axonal Transport;Behavior Control;Biology;Brain;Cells;Clinical;Code;Complex;conditioned fear;Dendrites;Development;Distal;Dorsal;experimental study;Exploratory/Developmental Grant;Failure;Family;fear memory;Hippocampus;Hypothalamic structure;Immunoprecipitation;Impairment;in vivo;in vivo evaluation;Individual;insight;Interneurons;Kinesin;knock-down;Knowledge;laser capture microdissection;Learning;lentiviral-mediated;long term memory;Maps;Medial;Mediating;Memory;Memory Disorders;Methodology;Microdissection;Modification;Molecular Analysis;Molecular Motors;Mus;neural circuit;Neuroglia;Neurons;Nucleus Accumbens;Organism;particle;Physiological;Play;Population;postsynaptic;Prefrontal Cortex;presynaptic;prevent;Process;promoter;Proteins;Rattus;Regulation;Reporting;Research;Ribosomes;RNA;RNA analysis;RNA Transport;Role;sea slug;Shock;Slice;spatial memory;Synapses;Synapsins;Target Populations;Testing;transcriptome sequencing;Translating;Translations;Untranslated RNA;Work

PROJECT_TITLE: Analysis of RNAs targeted to the long-distance projections of ventral hippocampus

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: NARRATIVE A parent's history of adverse childhood experiences (ACEs) can increase their child's obesity risk, though this association is not well understood. The impact of neighborhood environment is particularly understudied, despite its influence on both ACEs and obesity risk. This study will examine the relationship between a parent's history of ACEs, their child's obesity, and the family's neighborhood environment, in order to inform targeted place-based approaches to reducing obesity for millions of individuals affected by ACEs and obesity.

PI_NAMEs: SCHROEDER, KRISTA  (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Address;Adult;adverse childhood events;Affect;American;analytical method;Asthma;Behavior;Biology;Cardiovascular Diseases;Characteristics;Child;Childhood;Collection;Complex;Crime;Data;Data Set;Development;Economics;Elements;Environment;experience;Family;Food Access;Future;Geographic Locations;Goals;Green space;Health;health care availability;Health Promotion;Home;Hospitals;indexing;Individual;interest;Intervention;method development;Methods;Needles;Neighborhoods;novel;Obesity;obesity in children;obesity risk;obesogenic;Overweight;Parents;Philadelphia;Police;Policies;Population;Positioning Attribute;Poverty;Proxy;Race;Recording of previous events;Research;Risk;Role;Sampling;segregation;Source;Stress;Substance Use Disorder;Supermarket;Surveys;Testing;tool;Trauma;Work

PROJECT_TITLE: Illuminating associations between parent's adverse childhood experiences, children's obesity, and neighborhood environment

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: NARRATIVE The Boston University-Boston Medical Center (BU-BMC) Multi-Disciplinary Program for Promoting Research In MEdical Residency (PRIMER) will provide comprehensive ~2-year (contiguous 22 months of protected research time at 80% effort; 17.6 months of exclusive research time) transdisciplinary training for two internal medicine residents every year for the duration of the grant to pursue research in heart, lung, blood and sleep (HLBS) diseases, while ensuring their clinical training and medicine board eligibility, and transition to a K38 award as part of a clinical HLBS fellowship. The goals of PRIMER include mentored research under the guidance of a well-funded senior BU-BMC faculty member in one of four HLBS training tracks, career guidance by a senior mentor, professional development, and acquisition of key competencies for clinical research.

PI_NAMEs: KOTTON, DARRELL N.;NAYOR, MATTHEW G.;XANTHAKIS, VANESSA  (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Active Learning;Award;Bioinformatics;Blood;Boston;cardiovascular disorder epidemiology;career;Certification;Clinical;Clinical Competence;Clinical Medicine;Clinical Research;clinical training;Communication;Communities;Competence;Competency-Based Education;Computational Biology;Dedications;Development;Development Plans;Education;Educational Activities;Educational Curriculum;Eligibility Determination;Enrollment;Ensure;Environment;epidemiology study;Ethics;Evaluation;experience;Faculty;Fellowship;Fostering;Funding;Future;Genomics;Goals;Grant;Health system;Heart;Heart Diseases;Hematological Disease;Hospitals;implementation science;improved;Individual;Infrastructure;inner city;innovation;Institution;Institutional Review Boards;Internal Medicine;Internships;Journals;Leadership;leadership development;learning outcome;Lung;Lung Diseases;Manuscripts;Maps;Medical;Medical center;Medical Residency;Medicine;meetings;member;Mentors;Mentorship;Methods;Monitor;multi-ethnic;multidisciplinary;new technology;Outcome;patient oriented research;peer;peer coaching;Peer Review;Physicians;Positioning Attribute;Process;programs;Publications;Publishing;recruit;Regenerative Medicine;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Support;Research Training;Residencies;responsible research conduct;safety net;Scholarship;Science;Scientist;skills;Sleep;Sleep Disorders;Structure;success;Support Groups;systems research;Talents;technology platform;Therapeutic Equivalency;Time;Training;training opportunity;Training Programs;Translational Research;Underrepresented Populations;United States National Institutes of Health;Universities;Vocational Guidance;Woman;Writing

PROJECT_TITLE: PRIMER: Promoting Research In MEdical Residency

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (O2)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it is aimed at 1) increasing knowledge of the impacts of exposure to humanitarian emergencies on substance use and the development of substance use disorders and 2) informing methods of preventing substance use disorders among people affected by humanitarian emergencies. This project will evaluate the prevalence of substance use among internally displaced persons in Ukraine and adapt a substance use prevention intervention, likely Acceptance and Commitment Therapy-based sessions, specifically for use among this population. The proposed research is directly relevant to NIDA’s 2022-2026 Strategic Plan for Research via its focus on testing innovative approaches to prevent substance use disorders in real-world settings and has specific relevance for domestic populations in the United States, particularly the rising numbers of refugees and other individuals migrating due to the increasing number of global humanitarian crises.

PI_NAMEs: HOOK, KIMBERLY MICHELLE;KANE, JEREMY CALVIN;LUNZE, KARSTEN  (contact)

PROGRAM_OFFICER_NAME: COLLIER KIDEMU, KEVA WONTORIA

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Affect;Award;behavior change;Behavior Therapy;Behavioral;behavioral clinical trial;Communities;community engaged approach;community engagement;community partners;community setting;comorbidity;Conflict (Psychology);Control Groups;Country;Data;design;Development;Disparity population;displaced person;Eastern Europe;effective intervention;Effectiveness of Interventions;effectiveness-implementation RCT;Emergency Situation;epidemiologic data;Epidemiology;epidemiology study;Evaluation;evidence base;Exploration, Preparation, Implementation, and Sustainment;Exposure to;flexibility;Focus Groups;follow-up;Grant;group intervention;Health;Health behavior;Health Services Accessibility;Home;improved;Incidence;Income;Individual;innovation;Intervention;intervention refinement;Interview;Invaded;Knowledge;Learning Skill;Measures;Medical;member;Mental Health;Methods;migration;mindfulness;Modality;multidisciplinary;National Institute of Drug Abuse;Nongovernmental Organizations;Outcome;Participant;Pattern;Persons;Phase;Population;Population Intervention;Populations at Risk;post intervention;preference;Prevalence;prevent;Prevention strategy;Preventive;preventive intervention;primary outcome;Process;psychologic;Public Health;Qualitative Methods;Randomized;Randomized, Controlled Trials;Readiness;reduced substance use;Refugees;Reporting;Research;Risk;Risk Factors;Scientist;Services;Severities;shared decision making;Strategic Planning;substance use;Substance Use Disorder;substance use prevention;Suggestion;Surveys;Target Populations;Testing;Therapeutic Intervention;Training;treatment as usual;Ukraine;United States;Vulnerable Populations;War;Work

PROJECT_TITLE: Substance Use Prevention for Recently displaced Adults (SUPRA)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 MXS-E (O1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative The infectious disease tuberculosis (TB) is spread primarily through the air and kills over a million people every year. This proposal uses a new technique to better understand how subsets of the bacteria that cause TB, Mycobacterium tuberculosis, can survive stresses such as drying out and being exposed to antibiotics. Eventually, this may aid in finding methods of curing TB patients more quickly as well as preventing spread of the disease.

PI_NAMEs: BROWN, CHRISTOPHER DAVID;SAITO, KOHTA  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: aerosolized;Aerosols;Air;Antibiotics;Bacillus;Back;Bacteria;Bar Codes;Behavior;Biochemical Reaction;Biological;Biological Assay;Biology;Cell Separation;Cell Wall;Cells;Cellular biology;Characteristics;Clinical;Colony-forming units;combinatorial;Communicable Diseases;Complement;Complex;COVID-19;Data;Desiccation;design;Detection;Disease;Dryness;Ensure;Enzymes;Epigenetic Process;Event;Exposure to;Face;Foundations;Future;Genes;Genetic Transcription;Genome;Genus Mycobacterium;Goals;Grant;Growth;Guanine + Cytosine Composition;Heritability;Heterogeneity;Human;In Situ;In Vitro;indexing;Infection;insight;Liquid substance;logarithm;Measurable;Methods;Microfluidics;Minority;Minority Groups;Modeling;mycobacterial;Mycobacterium tuberculosis;Mycolic Acid;Nature;Nutrient;Outcome;pandemic disease;Patients;Pattern;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiological;Plasmids;Population;Population Dynamics;Positioning Attribute;Predisposition;prevent;Probability;Prokaryotic Cells;Protocols documentation;Publishing;Relapse;relapse risk;Resistance;Resolution;response;Reverse Transcription;Rifampicin resistance;Rifampin;Sampling;single-cell RNA sequencing;Solid;standard of care;Standardization;Starvation;Stress;Structure;Subgroup;Survivors;System;Techniques;Technology;Testing;Time;Transcript;transcriptome;transcriptome sequencing;transcriptomics;transmission process;treatment duration;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Work

PROJECT_TITLE: Interrogating complex mycobacterial population structures using single-cell RNA sequencing

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Antimicrobial Resistance;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Infectious Diseases;Microbiome

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: NARRATIVE  Interactions between the pathogenic Porphyromonas gingivalis and Fusobacterium nucleatum in the oral cavity exacerbates periodontal disease. There is a critical need for narrow spectrum antibacterials that selectively eliminate these bacteria, while sparing the beneficial bacteria in the mouth. This research proposes to characterize and advance a key enzyme in the bacterial fatty acid synthesis pathway, enoyl-ACP reductase II (FabK), as a narrow spectrum target for antibacterial therapy of periodontal disease.

PI_NAMEs: CHUKKAPALLI, SASANKA S;HEVENER, KIRK EDWARD;HURDLE, JULIAN G (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acceleration;Active Sites;Acyl Carrier Protein;Affect;alveolar bone;analog;Animal Model;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteria;Benchmarking;Binding;Biochemical;Biological;Biophysics;bone loss;Bone Resorption;Catalysis;Characteristics;Chemicals;Chronic;Clostridium difficile;cofactor;Colorimetry;Connective Tissue;craniofacial;Data;Debridement;Dental;Disease;drug candidate;drug discovery;Drug Targeting;dysbiosis;efficacy testing;Environment;Enzymatic Biochemistry;Enzymes;Epithelial Cells;Evaluation;Excision;Fatty Acids;Flavin Mononucleotide;Fusobacterium;Fusobacterium nucleatum;Future;Genetic;Genome;Gingiva;Goals;Growth;improved;in vivo;in vivo evaluation;Inflammation;inhibitor;insight;Intestines;Invaded;Isoenzymes;Knowledge;lipid metabolism;Lipids;malignant mouth neoplasm;Mechanics;Membrane;Membrane Lipids;Membrane Proteins;Messenger RNA;Metronidazole;Microbe;Microbial Biofilms;Microbiology;microbiota;microorganism interaction;Molecular Genetics;Mouth Diseases;Mus;National Institute of Dental and Craniofacial Research;Oral;oral bacteria;Oral cavity;Organism;Outcomes Research;Oxidoreductase;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Periodontal Diseases;Physiological;polymicrobial biofilm;Porphyromonas;Porphyromonas gingivalis;preference;prevent;programs;Publishing;Research;Risk Factors;Streptococcus;Streptococcus gordonii;structural biology;Structure;Systemic disease;Technology;Testing;Tetracyclines;Therapeutic;Thermodynamics;Tooth Loss;Translational Research;Vesicle;Virulence;Work

PROJECT_TITLE: Evaluation of a microbiota-sparing therapeutic concept for periodontal disease, involving removal of pathogenic Porphyromonas and Fusobacterium

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative Physician scientists and surgeon scientists are critical to research, innovations and novel therapeutics that improve the health and wellness of our nation. Research today provides hope and the foundation for new treatments and cures for tomorrow. The Ohio State University (OSU) R38 StARR Program aims to train Resident-Investigators in clinical training programs at the OSU Wexner Medical Center to pursue research relevant to immune mediated diseases, infections and novel immunotherapeutics.

PI_NAMEs: BUMGARDNER, GINNY L (contact)

PROJECT_TERMS: Address;Adult;Appointment;Awareness;biomedical informatics;Biometry;career;career development;Clinical;Clinical Services;clinical training;Clinical Trials;college;Communicable Diseases;Communication;Communities;Community Physician;Competence;Computational Biology;Databases;design;Development;Disease;Doctor of Philosophy;Education;education research;Educational Curriculum;Educational workshop;Environment;experience;Exposure to;Faculty;faculty mentor;Fortification;Fostering;Foundations;Funding;graduate medical education;Health;Health Services Research;Host Defense;Immune;Immune System Diseases;Immunology;Immunotherapeutic agent;improved;Individual;Infection;infectious disease treatment;innovation;Institution;Interdisciplinary Study;Internal Medicine;Knowledge;Leadership;Mediating;Medical;Medical center;Medical Residency;medical schools;Medicine;Mentors;Mentorship;Mind;multidisciplinary;Neurology;novel;novel strategies;novel therapeutics;Ohio;Operative Surgical Procedures;Oral;Pathogenesis;Pathology;Pathway interactions;peer coaching;peer networks;Pharmacogenomics;physician-scientist training program;Physicians;Physicians' Offices;Plastic Surgical Procedures;Postdoctoral Fellow;Preparation;Prevention;Productivity;Program Evaluation;programs;recruit;Reporting;Research;Research Design;Research Ethics;Research Personnel;Research Project Grants;Research Training;Residencies;Resources;responsible research conduct;Science;Scientific Advances and Accomplishments;Scientist;Series;skills;Students;success;Surgeon;surgical research;symposium;Talents;tool;Training;Training and Education;training opportunity;Training Programs;translational immunology;translational scientist;undergraduate student;Undifferentiated;United States;United States National Institutes of Health;Universities;Woman;working group;Writing

PROJECT_TITLE: The Ohio State University Research in Residency Physician Scientist Initiative


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: U24 Narrative The childhood physical and social home environment is critical for development, as children and adolescents are uniquely sensitive to environmental exposures and the home represents a large portion of their exposome. We have collected prospective data starting in pregnancy for 650 participants now entering adolescence and now seek to characterize their home exposome, including racism experienced, economic factors, as well as chemical exposures to conduct exposomic research that robustly informs how environment influences health in adolescence and into adulthood.

PI_NAMEs: HORTON, MEGAN K;ROSA, MARIA JOSE (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 16 year old;Address;Adolescence;Adolescent;adolescent health;Adult;Affect;Age;Air;Air Pollution;Award;Back;Big Data;Biological Sciences;Biometry;Birth;Blood Pressure;Body fat;Body mass index;Body System;Characteristics;Chemical Exposure;Chemicals;Child;Child Health;Childhood;Climate;Cognitive;cohort;Collaborations;Collection;community engagement;Complement;cost effective;critical period;Crows;Data;Data Collection;data dictionary;data harmonization;Data Linkages;data repository;Dedications;Development;Devices;Dose;Economic Factors;Educational Materials;Emotional;Environment;environmental chemical;Environmental Exposure;Environmental Health;Epidemiologist;Ethnography;experience;Exposure to;fine particles;follow-up;food insecurity;Fostering;Funding;Future;Grant;Growth;Health;health data;health determinants;health economics;Health protection;Home;Home environment;Household;immune function;Incubators;indoor air;Infrastructure;Intake;intergenerational;Internet;Intervention;Interview;Investments;K-Series Research Career Programs;Knowledge;Leadership;Life;Life Cycle Stages;Link;Longitudinal Studies;Maintenance;Measures;media use;medical schools;Medicine;Mental Health;Metabolic;Metal exposure;Metals;Methods;Mexico;Modeling;Modernization;molecular marker;Mothers;Nature;Neighborhoods;next generation;novel;novel strategies;Nutrient;Nutritional;Obesity;Organic Chemicals;Outcome;Paper;Participant;participant retention;pediatrician;Perinatal;perinatal environment;personalized nutrition;Phenotype;Physiological;pollutant;Positioning Attribute;Pregnancy;Prejudice;prenatal;programs;prospective;Public Health;Public Health Schools;Publishing;pulmonary function;racism;Recording of previous events;remote sensing;Reporting;Research;Research Personnel;Resources;respiratory;retention rate;Role;Sampling;Science;Scientist;sensor;Silicones;skills;Sleep;social;social factors;social media;Social Sciences;social stress;social stressor;socioeconomic disadvantage;Socioeconomic Status;socioeconomics;Standardization;Stress;stressor;success;Talents;Teenagers;Testing;Time;Tooth structure;transmission process;United States National Institutes of Health;Universities;Update;Walking;wearable device;Work;wristband

PROJECT_TITLE: The Programming Research in Obesity, GRowth, Environment and Social Stress (PROGRESS) Cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LKB-D (U2)]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The proposed summer program (Engaging Multidisciplinary Professional Opportunities for Women in Environmental Research) EMPOWER 2.0 will create research educational activities centered on the four steps of risk assessment—hazard characterization, dose-response relationships, exposure assessment, and risk characterization—to assess environmental contaminants in air and water found in Atlanta neighborhoods. We will provide hands-on training for high school students and teachers in air quality monitoring, environmental sampling, and toxicological assessment of model compounds to simulate exposure of ambient particulate matter, and bacteria commonly found in contaminated water.

PI_NAMEs: KING, ADRIENNE LESTER (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Address;Affect;African American;African American population;African American Women;Air;Area;Asian population;Award;Bachelor's Degree;Bacteria;built environment;career;Chemicals;Cities;college;combat;Communities;Compensation;Competence;contaminated water;Critical Thinking;Data;design;Disabled Persons;disparity gap;Dose;Education;education research;education resources;Educational Activities;Educational Curriculum;Educational process of instructing;eleventh grade;empowerment;Engineering;Enrollment;Ensure;environmental disparity;Environmental Health;Environmental Pollutants;Equity;Ethics;Evaluation;experience;faculty mentor;Failure;formative assessment;Foundations;Goals;graduate school;hazard;Hazard Assessment;Health;high school;High School Faculty;High School Student;higher education;Hispanic Women;Human;Inequality;innovation;Institution;Institutional Racism;Instruction;interest;Intervention;Investments;Knowledge;Learning;learning materials;Location;Mathematics;Mentorship;Minority;Modeling;Monitor;multidisciplinary;Nature;Neighborhoods;Outcome;Particulate Matter;Pathway interactions;Prevalence;prevent;Problem Solving;Process;Process Assessment;programs;Psyche structure;Public Health Schools;racial disparity;racial population;racism;Reporting;Research;Research Personnel;Research Training;response;Risk;Risk Assessment;risk selection;Safety;Sampling;Schools;Science;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;Scientific Inquiry;Secondary Schools;Sexism;Shapes;skills;Source;STEM field;Structure;student mentoring;student participation;Students;success;summer program;summer research;teacher;teacher mentor;Techniques;Technology;Testing;theories;Thinking;tool;toxicant;Toxicology;Training;Training and Education;trend;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Universities;vulnerable community;Water;White Women;Woman;Work

PROJECT_TITLE: EMPOWER 2.0 (Engaging Multi-Disciplinary Professional Opportunities for Women in Environmental Research)

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 BWD-W (25)]


NIH_SPENDING_CATS: Clinical Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_NAME: EMORY UNIVERSITY

PHR: NARRATIVE Fifty years ago, Michigan residents were exposed to polybrominated biphenyls (PBBs), a persistent endocrine- disrupting chemical through their food and work. The Michigan PBB environmental epidemiology cohort (EEC) now includes over 7500 individuals and three generations but lacks representation from Michigan’s urban residents and younger people who were exposed to PBB in childhood or in utero, both of whom may have unique exposures and health concerns. The diversification of the Michigan PBB EEC and expansion of data sharing will allow future researchers to address health disparities, particularly within the context of the exposome.

PI_NAMEs: MARCUS, MICHELE  (contact);PEARSON, MELANIE ALICE

PROJECT_TERMS: Address;Adult;Advisory Committees;Age;Biological;black women;Blood;Chemical Exposure;Chemicals;Childhood;cohort;Collaborations;college;Common Data Element;Communication;Communities;community engaged research;community engagement;Community Participation;community partners;community partnership;contaminated water;continuing medical education;Country;Data;data harmonization;Data Set;data sharing;Daughter;Development;diphenyl;Disasters;Doctor of Philosophy;doctoral student;Documentation;Dose;Endocrine Disruptors;Enrollment;Ensure;Environmental Epidemiology;Environmental Exposure;Environmental Health;Environmental Impact;Epidemiologist;Epidemiology;Epigenetic Process;estrogenic;experience;Exposure to;Family;family building;Flame Retardants;Focus Groups;Food;Food Contamination;Funding;Future;Generations;genetic pedigree;Germ Cells;Grant;Health;health disparity;Health Personnel;Health Status;Historically Black Colleges and Universities;Humanities;improved;in utero;Individual;Infrastructure;innovation;Institution;Joints;Knowledge;Language;Learning;Life;Life Cycle Stages;Link;meetings;metabolomics;Metadata;Methods;Michigan;Minority;National Institute of Environmental Health Sciences;neoplasm registry;next generation;pandemic disease;Paper;Participant;Peer Review;Persons;Poly-fluoroalkyl substances;Polybrominated Biphenyls;Population;Positioning Attribute;Postdoctoral Fellow;Pregnancy loss;Property;Puberty;Publications;R24;Recording of previous events;recruit;Registries;Reporting;reproductive;Research;Research Personnel;Role;Running;Rural;Sampling;Scientist;Signal Transduction;social factors;Somatic Cell;Structural Racism;student mentoring;Students;Superfund;symposium;Testing;Training;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities;Update;Urban Community;virtual;Water Supply;Woman;Work

PROJECT_TITLE: The Michigan PBB Cohort: A unique, highly exposed community followed for 50 years and three generations


ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Relevance HIV/AIDS remains an important threat to global public health; at least 38 million people are currently infected with HIV-1 and only ~68% are being treated with anti-retroviral drugs. A vaccine to protect against HIV-1/AIDS is urgently needed, especially in the developing world. Here, we will use novel mouse and primate animal models to decipher the developmental pathways of protective neutralizing antibodies and use this information to improve our immunization regimens, concentrating on developing sequential priming and boosting immunogens that prevent elicitation of off-target antibodies.

PI_NAMEs: BJORKMAN, PAMELA J (contact);HAHN, BEATRICE H;NUSSENZWEIG, MICHEL C

PROGRAM_OFFICER_NAME: DANG, QUE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Affinity;Animal Model;Animals;Anti-Retroviral Agents;Antibodies;Antibody Repertoire;Antibody Response;Antibody titer measurement;Antigens;Attenuated;B-Lymphocytes;Binding Sites;Bioinformatics;Biological Assay;biophysical analysis;booster vaccine;Collaborations;Data;design;Development;Electron Microscopy;Engineering;Enzyme-Linked Immunosorbent Assay;Epitope Mapping;Epitopes;Event;Evolution;experimental study;Failure;Feedback;Funding;Germ Lines;Goals;Helper-Inducer T-Lymphocyte;HIV vaccine;HIV-1;HIV-1 vaccine;HIV/AIDS;Human;Immune Sera;Immunization;immunogenicity;Immunologics;Impairment;improved;Laboratories;Left;Macaca mulatta;Membrane;Memory B-Lymphocyte;Messenger RNA;Modeling;Molecular;Monoclonal Antibodies;mRNA lipid nano particle vaccine;Mus;Mutation;nanoparticle;neutralizing antibody;next generation;novel;Oryctolagus cuniculus;Outcome;Pathway interactions;Persons;Pharmaceutical Preparations;Phylogenetic Analysis;polyclonal antibody;Polysaccharides;pressure;prevent;Primates;protective pathway;protein expression;Proteins;Public Health;Publications;recruit;Regimen;Research;response;RNA vaccine;scaffold;Scientific Advances and Accomplishments;screening;simian human immunodeficiency virus;Structure of germinal center of lymph node;synergism;Testing;tool;Transgenic Mice;Vaccination;Vaccine Design;vaccine platform;Vaccine Research;Vaccines;Viral;Virus

PROJECT_TITLE: Developing Immunogens to Elicit Broadly Neutralizing anti-HIV-1 Antibodies

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 VS-A (S1)]


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: BJORKMAN, PAMELA J (contact)

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Administrative Personnel;animal care;Antibodies;Antigens;Award;Budgets;cloud based;Collaborations;Communication;Communities;Consult;Data;data management;data sharing;Databases;Dedications;design;Electronics;Ensure;experience;experimental study;Funding;Goals;Grant;Guidelines;HIV Antibodies;HIV-1;Human Resources;IACUC;Information Technology;Infrastructure;Institution;Lead;Leadership;Manuscripts;material transfer agreement;Measures;meetings;member;Monitor;Occupational activity of managing finances;Pennsylvania;prevent;programs;Protocols documentation;Reporting;Research;Research Personnel;Resources;Science;success;symposium;United States National Institutes of Health;Universities;Vaccines;videoconference;web page;web site;Work


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Abbreviations;Affinity;Affinity Chromatography;AIDS Vaccines;Animals;Antibodies;Antibody Affinity;Antigens;assay development;B-Lymphocytes;Binding;Biochemical;Biological Assay;Cells;Cellular Assay;cloud based;Collaborations;Complex;Cross Reactions;cross reactivity;Custom;data access;Data Analyses;data management;design;Endotoxins;env Gene Products;Enzyme-Linked Immunosorbent Assay;Escherichia coli;Evaluation;Experimental Models;experimental study;Freedom;Germ Lines;gp160;HIV envelope protein;HIV Envelope Protein gp120;HIV-1;Human Resources;Immunization;Immunize;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;In Vitro;instrument;Kinetics;Libraries;Light;Liquid substance;Macaca mulatta;Mammalian Cell;Measures;Membrane;Methodology;Methods;Molecular Sieve Chromatography;Monitor;Monoclonal Antibodies;Mus;nanomaterials;nanoparticle;neutralizing antibody;Oryctolagus cuniculus;Polysaccharides;Postdoctoral Fellow;Procedures;Production;Property;protein expression;Proteins;Protocols documentation;receptor binding;Recombinant Proteins;Recovery;Regimen;Research Assistant;Research Personnel;Robot;Scheme;screening;Serum;simian human immunodeficiency virus;Students;Surface;Surface Plasmon Resonance;System;Testing;Time;Training;Vaccinated;Vaccination;vaccine discovery;vaccine trial;Yeasts


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Abbreviations;Affect;Animal Model;Animals;Antibodies;Antibody Formation;Antigens;Binding;Binding Sites;Biological Assay;Collaborations;Data;design;Development;Engineering;Enzyme-Linked Immunosorbent Assay;Epitope Mapping;Epitopes;Evolution;experimental study;Germ Lines;HIV;HIV envelope protein;HIV Envelope Protein gp120;HIV-1;HIV-1 vaccine;Immunization;Immunize;Immunoglobulin G;Impairment;improved;In Vitro;in vivo;Infection;Infection prevention;Macaca mulatta;Maps;Memory B-Lymphocyte;Molecular Sieve Chromatography;Monoclonal Antibodies;Mutation;nanoparticle;neutralizing antibody;particle;Polysaccharides;Preparation;pressure;prevent;protein expression;Proteins;recruit;Regimen;response;scaffold;Serum;Shapes;simian human immunodeficiency virus;Structure of germinal center of lymph node;Surface Plasmon Resonance;Transgenic Mice;Vaccination;vaccine candidate;Vaccines;Viral;Wild Type Mouse;Work


PROJECT_TERMS: Abbreviations;Affinity;Animal Model;Animals;Antibodies;Antibody Affinity;Antibody Response;Antigens;Apical;Autologous;Automobile Driving;B-Lymphocytes;Binding;Binding Sites;CD4 Positive T Lymphocytes;Cell Lineage;Clinical;Collaborations;design;Development;Dose;env Gene Products;Epitope Mapping;Epitopes;Event;Feedback;Frequencies;Generations;Germ Lines;HIV;HIV-1;Human;Immunization;Immunogenetics;immunogenicity;improved;Infection;Laboratories;lipid nanoparticle;Macaca mulatta;Maps;Membrane;Messenger RNA;Modeling;Molecular;Monkeys;Monoclonal Antibodies;mRNA lipid nano particle vaccine;Mutation;nanoparticle;neutralizing antibody;novel;Pathway interactions;Pattern;Peptides;Polysaccharides;preclinical trial;Process;protective efficacy;Proteins;Rectum;Regimen;response;Rhesus;simian human immunodeficiency virus;Specificity;success;Testing;Translating;Vaccinated;Vaccination;Vaccines;Variant;vector;Viral;Work


PROJECT_TERMS: Abbreviations;Acquired Immunodeficiency Syndrome;Adoptive Transfer;Affect;Affinity;Animal Experiments;Antibodies;Antibody Repertoire;Antibody Response;Antigens;B-Cell Development;B-Lymphocytes;base;Binding;Binding Sites;biochemical tools;Cells;Complementarity Determining Regions;Data;design;Development;Disease;Epitopes;Evolution;experimental study;Feedback;Frequencies;Genes;genetic element;Germ Lines;Goals;Helper-Inducer T-Lymphocyte;HIV vaccine;HIV-1;HIV-1 vaccine;Human;IGH@ gene cluster;Immune response;Immune system;Immunization;Immunoglobulin Somatic Hypermutation;Immunologics;improved;in vivo;Infection;Intervention;Knock-in;Knock-in Mouse;Knowledge;Laboratories;Major Histocompatibility Complex;Masks;Membrane;Memory B-Lymphocyte;Modeling;Monoclonal Antibodies;mouse model;Mus;mutant;neutralizing antibody;novel;Outcome;Peptide/MHC Complex;Peptides;Persons;Physiological;polyclonal antibody;Publishing;Reaction;Recombinants;recruit;Regimen;Reporting;Reproducibility;response;Specificity;Structure of germinal center of lymph node;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;Time;Transgenic Mice;V3 Loop;vaccination strategy;vaccine development;Vaccines;Wild Type Mouse