NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Vaccines;Drug Abuse (NIDA only);Emerging Infectious Diseases;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Substance Misuse;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE. Almost nothing is known about innate memory in human patients living with HIV, or in HIV+ patients who are vaccinated. These studies will apply EpiTOF and CITE-seq to characterize blood cells from subjects enrolled in the ACTG A5369 DNA vaccine trial of HIV+ individuals to characterize innate immunity.

PI_NAMEs: UTZ, PAUL JOSEPH (contact)

PROGRAM_OFFICER_NAME: DANG, QUE

PROJECT_TERMS: 2019-nCoV;active method;Adjuvant;AIDS clinical trial group;Antigens;antiviral immunity;arm;ATAC-seq;Attenuated;Autoimmune Diseases;Bacteria;BCG Live;Blood Cells;booster vaccine;CD14 gene;CD34 gene;Cell Differentiation process;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;ChIP-seq;Chromatin;Chronic;Color;Communicable Diseases;COVID-19 vaccination;COVID-19 vaccine;Cryopreservation;cytokine;Cytometry;Data;Data Set;Dendritic Cells;Dengue;DNA;DNA Vaccines;Elements;Enrollment;Epigenetic Process;epigenomics;Evolution;FCGR3B gene;Frequencies;Future;Gene Expression Profile;Genes;Genetic Transcription;Goals;Hematopoietic stem cells;Histone Deacetylation;histone methylation;Histones;HIV;HIV Infections;HIV prevention trial;Human;Immune;Immunity;Immunization;Immunize;Immunoglobulin G;Immunologic Memory;Immunology;Impairment;Individual;Inflammatory;Influenza;Influenza vaccination;influenza virus vaccine;Innate Immune Response;innovation;Interferon Type II;Interferons;Leukapheresis;Link;Macaca;Maps;Measurement;Measures;Memory;Messenger RNA;Methods;monocyte;Myelogenous;Myeloid Cells;Natural History;Natural Immunity;Natural Killer Cells;novel;Outcome;Paper;Participant;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Persons;Pfizer-BioNTech COVID-19 vaccine;Placebos;Plasma;Population;Post-Translational Protein Processing;preservation;Production;Research Personnel;Resistance to infection;Resolution;response;Sampling;seasonal influenza;simian human immunodeficiency virus;single cell analysis;SIV;Stains;System;T cell response;T-Lymphocyte;Testing;Time;Toll-like receptors;Training;Transcript;Transcription Factor AP-1;transcriptomics;treatment arm;Vaccinated;Vaccination;vaccine platform;vaccine trial;Vaccinee;Vaccines;Validation;Viral Genes;Virus;ZIKA

PROJECT_TITLE: Epigenetic Histone Landscape Profiles in HIV


ADMINISTERING_IC: EB

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Social Determinants of Health

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE The proposed Enhancing Science, Technology, EnginEering, and Math Educational Diversity research education program seeks to recruit, retain, and graduate underrepresented minority students that are community college transfers into a bachelor's degree in bioengineering and prepare them for the pursuit of a Ph.D. or M.D./Ph.D. degree and research career. The proposed research is relevant to the part of NIH's mission that pertains to developing the human resources that will ensure the Nation's capability to prevent disease.

PI_NAMEs: NEEVES, KEITH B (contact);WALKER, TARIK DOBBS

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Academic Medical Centers;Accreditation;apprenticeship;Associate Degree;Bachelor's Degree;Biomedical Engineering;Biomedical Research;bridge program;broadening participation research;career;Colorado;community college;computational reasoning;Credentialing;Data;Degree program;demographics;design;Disease;Doctor of Medicine;Doctor of Philosophy;Education;Education Projects;education research;Educational workshop;Employment;Engineering;Enrollment;Ensure;Ethnic Origin;experience;Faculty;Familiarity;Foundations;Goals;Graduate Degree;graduate school;Hispanic;Home;Human Resources;improved;Individual;innovation;Institution;Latino;Lead;Leadership;Learning;Life;Low income;matriculation;Medical;medical schools;Medicine;Mentors;Minority Groups;Minority-Serving Institution;Mission;Modeling;neglect;novel;Outcome;Performance;Population;Postbaccalaureate;Preparation;prevent;Professional Competence;programs;recruit;Research;Research Personnel;Research Training;Scholars Program;Scholarship;Science;Science, Technology, Engineering and Mathematics Education;Services;skills;socioeconomics;STEM program;Structure;student mentoring;Students;summer research;Support Groups;Talents;Thinking;Training;transfer student;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;university student

PROJECT_TITLE: ESTEEMED Scholars Program in Bioengineering at the University of Colorado Denver


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetics;Hematology;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE (from the parent grant application) T-cell lymphomas (TCL), comprising 10-15% of non-Hodgkin lymphomas (NHL) in North America, are molecularly heterogeneous, poorly understood, and are associated with poor clinical outcomes. Most patients will develop recurrent or refractory disease that is resistant to currently available therapies. In an effort to better understand mechanisms that promote TCL pathogenesis and identify rational and clinically translatable therapeutic strategies, we will investigate the role of the T-cell receptor and the transcription factor GATA-3 in a genetically engineered TCL model and primary patient specimens using complementary genetic and pharmacologic approaches.

PI_NAMEs: WILCOX, RYAN A (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Address;Antigen Presentation;Antigen-Presenting Cells;Antigens;Applications Grants;Automobile Driving;Characteristics;Chemoresistance;chemotherapy;chromatin remodeling;Chromosome Deletion;Clinical;clinical translation;Clinical Trials Design;Cytokine Receptors;Data;Disease;Disease Progression;Disease Resistance;engineered T cells;experience;experimental study;Family;gain of function;GATA3 gene;Gene Expression;Genetic;genetic evolution;genetic manipulation;Genetic Transcription;Goals;Growth;host microbiome;Human;improved outcome;In Vitro;in vivo;loss of function;Lymphoma;Lymphoma cell;Lymphomagenesis;Macrophage;Major Histocompatibility Complex;Malignant - descriptor;Modeling;Molecular;Mus;Mutate;Non-Hodgkin's Lymphoma;North America;novel;novel therapeutic intervention;Outcome;Ovalbumin;parent grant;Pathogenesis;patient derived xenograft model;Patient-Focused Outcomes;Patients;pharmacologic;Phosphotransferases;programs;Proliferating;Receptor Activation;Receptor Signaling;Recurrence;Recurrent disease;Refractory Disease;Regulation;Research;Resistance;Role;SMARCB1 gene;Specimen;SWI/SNF Family Complex;T-Cell Activation;T-Cell Antigen Receptor Specificity;T-Cell Development;T-Cell Lymphoma;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;TP53 gene;transcription factor;tumor microenvironment;Up-Regulation;Zinc Fingers

PROJECT_TITLE: THE T-CELL RECEPTOR'S ROLE IN T-CELL LYMPHOMA PATHOGENESIS


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

ORG_STATE: PA

PHR: Back pain is frequently associated with degeneration of the intervertebral discs (IVDs) of the spine and represents a significant health and economic burden, particularly to our active duty military and Veteran populations. Current treatments for disc degeneration, such as spinal fusion, are limited in that they do not restore healthy disc structure or function. The purpose of this supplemental award is to provide a more detailed analysis of the inflammatory milieu of the degenerating IVD and evaluate the immunomodulatory potential of a novel tissue engineered IVD replacement. This will be achieved via long term studies in a large animal model under clinically relevant conditions. Immunophenotyping of cells within the degenerated IVDs and engineered disc replacements will be used to evaluate the immunomodulatory effect of the engineered replacements and how loading impacts these features. This work will drive clinical translation of our tissue engineered disc, significantly improving treatment options for Veterans suffering from disc degeneration and back pain.

PI_NAMEs: MAUCK, ROBERT L (contact)

PROJECT_TERMS: active duty;Animal Model;Animals;Award;Back Pain;Biological Process;Cells;Cervical;Cervical spine;Chondroitin ABC Lyase;Chronic;chronic pain;Clinical;clinical translation;Clinical Treatment;clinically relevant;Economic Burden;Engineering;Environment;Euthanasia;Evaluation;Future;Goals;Goat;Grant;Health;Human;Immobilization;Immune;immunohistochemical markers;Immunophenotyping;immunoregulation;Implant;implantation;improved;Inflammation;Inflammatory;inflammatory milieu;inflammatory modulation;Inflammatory Response;Injections;Injury;insight;Intervertebral disc structure;intervertebral disk degeneration;Invaded;Longitudinal Studies;Low Back Pain;Macrophage;mechanical load;Mechanics;Mediating;Mediation;Mentorship;Metals;Military Personnel;military veteran;Modeling;Motion;Natural regeneration;next generation sequencing;novel;nucleus pulposus;Operative Surgical Procedures;Parents;Pathology;Phagocytes;restoration;sample fixation;single cell sequencing;skills;Source;Spinal;Spinal Fusion;Structure;Therapeutic;Tissue Engineering;Translations;Validation;Vertebral column;Veterans;Work

PROJECT_TITLE: Tissue Engineered Total Disc Replacement in a Large Animal Model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 DEIR-N (01)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: Chicago

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: We propose a novel integrative approach that targets the 3 main morphological changes that underlie erectile dysfunction (ED), which are cavernous nerve (CN) degeneration, smooth muscle apoptosis, and penile fibrosis. This application is innovative because we are developing two novel peptide amphiphile nanofiber hydrogels for delivery of sonic hedgehog (SHH) protein to the CN and to the penis to promote regeneration and prevent penile apoptosis. These studies will have broad clinical application and impact since SHH nanofibers can be used to regenerate any peripheral nerve that SHH plays a role in maintaining nerve integrity including the CN, sciatic and facial nerves and because the SHH nanofibers are highly translatable for treatment of ED in prostatectomy and diabetic patients.

PI_NAMEs: PODLASEK, CAROL ANN (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: Acceleration;Adult;Affect;aged;antagonist;Apoptosis;Apoptotic;Architecture;axonal degeneration;Binding;BMP4;Brain-Derived Neurotrophic Factor;Cells;Cholesterol;Clinical;clinical application;clinical translation;Collagen;Corpora Cavernosa;Data;Demyelinations;Denervation;design;Development;diabetic;diabetic patient;Disease;Effectiveness;effectiveness evaluation;Endosomes;Endothelium;Erectile dysfunction;Facial nerve structure;Fatty Acids;Fibrosis;Growth Factor;Half-Life;Human;Hydrogels;improved;in vivo;ineffective therapies;inhibitor;Injury;innovation;interest;Intervention;Kinetics;Limb Bud;Link;male health;men;Modeling;Morphology;nanofiber;Nanotechnology;Natural regeneration;Nerve;Nerve Crush;Nerve Degeneration;Nerve Fibers;nerve injury;Nerve Regeneration;nerve supply;Neurites;novel;novel therapeutics;Operative Surgical Procedures;Organ Culture Techniques;Pathway interactions;Patients;penis;peptide amphiphiles;Peptides;Peripheral Nerves;Preparation;preservation;prevent;Prevention;Prevention strategy;Process;Prostatectomy;Proteins;prototype;Pulmonary Fibrosis;Quality of life;Rat Protein;Rattus;response;retrograde transport;sciatic nerve;SHH gene;Smooth Muscle;smoothened signaling pathway;Sonic Hedgehog Pathway;treatment strategy;Vascular Endothelial Growth Factors

PROJECT_TITLE: 3-Way Approach for ED Prevention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(90)]


NIH_SPENDING_CATS: Aging;Cancer;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: SHREVEPORT

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: Narrative The molecular mechanisms responsible for the higher incidence of developing early and more aggressive prostate cancer (PCa) in African American (AA) men are still unknown. We aim to investigate the functional consequences of common genetic alterations affecting the tumor microenvironment (TME) associated with increased risk. In addition, we will evaluate the clinical utility with emphasis on developing potential new therapies.

PI_NAMEs: FRANCO CORONEL, OMAR  (contact)

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: Address;Affect;African American;anti-cancer research;Area;Behavior;Binding;Biological;Biological Factors;Cancer Biology;cancer cell;carcinogenesis;Caucasians;Cells;Cellular biology;chemokine;Clinical;colon cancer progression;Colon Carcinoma;Data;Development;Diagnosis;Disease;Disease Progression;Disparate;Down-Regulation;Eph Family Receptors;EPHB2 gene;Ephrins;Epithelial-Stromal Communication;Epithelium;Experimental Models;experimental study;Family;Fibroblasts;Genes;Goals;High Prevalence;high risk;Human;Impairment;improved;In Vitro;in vivo;in vivo Model;Incidence;Inflammatory;Inherited;innovation;Intervention;Ligands;Link;Malignant neoplasm of prostate;Malignant Neoplasms;Mediator;Medical;member;men;Molecular;Molecular Target;mortality;Motility;multidisciplinary;Mutation;Nature;neglect;neoplastic cell;next generation sequencing;novel;novel therapeutics;Oncogenic;Outcome;Pathogenicity;Pathway interactions;Patients;Penetrance;Population;Proliferating;Prostate;prostate cancer cell;prostate cancer cell line;prostate cancer model;prostate cancer prevention;prostate cancer progression;prostate cancer risk;Prostate Cancer therapy;Prostatic Neoplasms;Protein Tyrosine Kinase;Race;racial disparity;racial diversity;receptor;receptor binding;Regulation;Reporting;Research;Risk;Role;Sampling;Signal Transduction;Single Nucleotide Polymorphism;Socioeconomic Factors;Stromal Cells;Testing;Tissues;tumor;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenesis;Tumorigenicity;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Functional Consequences of Racially Associated Ephrin Alterations on the Prostate Tumor Microenvironment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-B(55)R]


ADMINISTERING_IC: TR

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Genetics

ORG_CITY: MADISON

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: ! Narrative Naturally occurring (spontaneous) diseases in companion animals, such as epilepsy, glaucoma, or hemophilia, can advance our understanding of similar diseases in human patients. This proposal will support the inclusion of veterinary clinician-scientists, who have expertise in these animal diseases, in interdisciplinary research teams that can address human health problems from multiple perspectives.

PI_NAMEs: TREPANIER, LAUREN A (contact)

PROGRAM_OFFICER_NAME: MERCHANT, CAROL

PROJECT_TERMS: Acceleration;Address;Animal Disease Models;Animal Diseases;Animal Model;Animals;Award;Biomedical Research;biomedical scientist;Breeding;Canis familiaris;Cardiomyopathies;career;Chronic Disease;Clinical;Collaborations;Communication;companion animal;Companions;comparative;Complement;Complex Genetic Trait;Controlled Study;cost;Degenerative polyarthritis;Development;Disease;disease phenotype;Disease Progression;Doctor of Philosophy;Domestic Animals;early-career faculty;Educational workshop;Engineering;Environmental Exposure;Epilepsy;evidence base;experience;Faculty;Family suidae;Felis catus;Fellowship;flexibility;Funding;gene interaction;Genetic Engineering;genomic locus;Glaucoma;Grant;Health;Health Professional;Hemophilia A;Heterogeneity;Human;human disease;Immersion;Inbreeding;Infrastructure;Interdisciplinary Study;interest;Knowledge;Laboratories;Life;Medical;medical specialties;member;Mentors;Mentorship;model generalizability;Modeling;National Center for Advancing Translational Sciences;Nursing Faculty;Pathogenesis;Patients;Physicians;Positioning Attribute;preclinical trial;Productivity;programs;recruit;Reporting;Research;Research Personnel;Research Training;Residencies;response;Rodent;Rodent Model;role model;Sampling;Science;Scientist;skills;Specialist;symposium;Teaching Hospitals;Testing;Thinness;Training;Translating;translational goal;translational medicine;Translational Research;United States National Institutes of Health;Veterinarians;Walking;working group;Writing

PROJECT_TITLE: Translational Research Workforce Training: Leveraging the Veterinary Specialist


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Primary progressive aphasia (PPA) is a degenerative condition of language loss that affects many patients with frontotemporal dementia (FTD) and Alzheimer's disease (AD), and for which effective treatments are currently lacking. While recent evidence suggests that noninvasive neuromodulation techniques like transcranial direct current stimulation (tDCS) may be helpful, a critical barrier to further progress in this field is the absence of research that: 1) examines the role of neuroplasticity in the language system in persons with PPA, 2) reveals how neuromodulation alters the dynamics of the language network in this disorder, and 3) uses advances in clinical and neuroscientific understanding of PPA to determine which individuals are most likely to respond to treatment. This project addresses these knowledge gaps by combining a sham-controlled treatment trial of high-definition tDCS (HD-tDCS) and concurrent behavioral language therapy with advanced neuroimaging network analysis, in order to determine where in the brain and when in the course of disease to stimulate in PPA, and to elucidate which patients neuromodulation interventions can be applied to most effectively.

PI_NAMEs: HAMILTON, ROY H (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Address;Advanced Development;Affect;Age-associated memory impairment;Alzheimer's Disease;Alzheimer's disease patient;Anodes;Anterior;Area;Behavioral;behavioral response;Brain;Brain region;cerebral atrophy;Clinical;clinical phenotype;Clinical Trials;Cross-Over Studies;Data;Degenerative Disorder;density;Disease;Disease Progression;Double-Blind Method;effective therapy;frontal lobe;frontotemporal degeneration;Frontotemporal Dementia;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Graph;Image;improved;indexing;Individual;Injury;insight;Intervention;Intervention Trial;Investigation;Knowledge;Language;language impairment;Language Therapy;Left;Location;Measures;meetings;Methods;Modeling;multimodal data;Nature;Nerve Degeneration;neural;neurodegenerative dementia;Neurodegenerative Disorders;neuroimaging;Neuronal Plasticity;neuroregulation;noninvasive brain stimulation;novel;Participant;Pathway Analysis;Patients;Pattern;Performance;Persons;predicting response;Primary Progressive Aphasia;Production;Progressive Aphasias;Property;Quality of life;Randomized;Research;response;Role;Semantics;Site;Speech;Statistical Data Interpretation;Statistical Models;statistics;stroke-induced aphasia;Syndrome;System;Techniques;Testing;Therapeutic;transcranial direct current stimulation;treatment effect;treatment trial;Variant;Work

PROJECT_TITLE: Treating primary progressive aphasia and elucidating neurodegeneration in the language network using transcranial direct current stimulation


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Vaccine Related

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Modified Narrative Section  People with HIV (PWH) are almost always co-infected with CMV, and CMV can hijack the human immune system in ways that allows HIV to persist in the setting of modern antiretroviral therapy. Leveraging clinical trials to collect appropriate samples and data we will test a new CMV drug in PWH, and we will rigorously elucidate the mechanisms of how CMV helps HIV persist, like clonal expansion of CD4+ T cells carrying HIV and exhausting immune responses. By understanding exactly how CMV promotes HIV persistence, we can develop better HIV cure strategies.

PI_NAMEs: GIANELLA WEIBEL, SARA  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Affect;AIDS clinical trial group;Antigens;antiretroviral therapy;Biological Assay;Blood specimen;Bystander Effect;CCR5 gene;CD4 Positive T Lymphocytes;CD8B1 gene;Cells;Chronic;Clinical Trials;Clonal Expansion;Clonality;co-infection;Collecting Cell;Complement;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Vaccines;Data;design;DNA;DNA Integration;Enzyme-Linked Immunosorbent Assay;Event;exhaust;Flow Cytometry;Frequencies;Funding;Future;Gene Expression Profile;Genes;Genomic DNA;Granzyme;Health;HIV;HLA-DR Antigens;Human;Human Herpesvirus 4;Immune;immune checkpoint;Immune response;Immune system;Immune System Diseases;Immunologics;Impairment;in vivo;Individual;Inflammation;Inflammatory;Influenza;integration site;Interleukin-1 beta;Interleukin-10;Interleukin-6;Intervention;Investments;Knowledge;Leukapheresis;Measures;memory CD4 T lymphocyte;Methods;Modernization;monocyte;Morbidity - disease rate;Natural Killer Cells;novel;Participant;pathogen;Pathway interactions;perforin;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Placebos;Plasma;Play;prevent;programmed cell death protein 1;Proviruses;randomized trial;Research;Research Design;RNA;Role;Sampling;single-cell RNA sequencing;Sorting;success;T cell receptor repertoire sequencing;T-Lymphocyte;Testing;Time;TNF gene;TRIM Gene;United States National Institutes of Health;vaccine trial;Vaccines;Variant;Viral;Viral Antigens;Virus;Virus Activation;Virus Replication

PROJECT_TITLE: Mechanisms of CMV Replication on HIV Persistence

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: The objective of this technology optimization is to enable broad adoption of flexible polymer neural interface technology by engaging the neuroscience user community and developing designs that can be used across species from mouse to nonhuman primate. This work will result in library of different designs that target multiple brain regions from cortical to sub-cortical to deep brain as well as the specialized methods to enable accurate implantation to these targets. This collaborative effort advances polymer microelectrode array technologies to meet the large scale, high density goals of the BRAIN Initiative and establishes a dissemination path to make them widely available to the neuroscience and neuroengineering community.

PI_NAMEs: MENG, ELLIS  (contact);SONG, DONG

PROGRAM_OFFICER_NAME: HWANG, GRACE MEI-HUA

PROJECT_TITLE: Optimization of Flexible Neural Probe Arrays for Multi-Region Recordings in Rodents and Nonhuman Primates


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurosciences;Pain Research;Racial and Ethnic Minority Health Research;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed study will begin the development of a culturally adapted psychosocial intervention for chronic pain for American Indian/Alaska Native (AI/AN) individuals at the Portland Area Indian Health Service – Yakama Service Unit. In the short-term, the study will provide the information necessary for adapting interventions (e.g., AI/AN pain beliefs, treatment preferences, perspectives on chronic pain measures) as well as information on whether it is feasible to conduct a fully-powered randomized controlled trial. In the long-term, the study will provide an evidence-based process for culturally adapting chronic pain interventions for tribal communities and potentially decrease pain disparities by providing effective psychosocial techniques for pain management that decrease pain intensity, decrease pain interference, and increase quality of life.

PI_NAMEs: NEWMAN, ANDREA K (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, ANGELA R

PROJECT_TERMS: adherence rate;Adult;Affect;Aftercare;Alabama;Alaska Native;Alaska Native population;American;American Indian Population;American Indians;Anxiety;Area;Award;Behavioral;Belief;Caring;Chronic intense pain;chronic pain;chronic pain management;Clinical;Clinical Trials;Cognitive;Cognitive Therapy;Communities;community based participatory research;community based research;community partners;community setting;cost;Country;cultural competence;culturally appropriate intervention;Dancing;Data;Development;disability;Disparity;Education;Educational process of instructing;efficacy evaluation;Environment;Evaluation;evidence base;feasibility testing;Feedback;Focus Groups;follow-up;Fostering;Future;Goals;Guidelines;Health Personnel;health training;improved;Indigenous;Individual;Inequality;Institutional Racism;interest;Intervention;Intervention Studies;Knowledge;Learning;Low income;Manuals;Medical;medical specialties;Medicine;member;Mental Depression;Mentors;mindfulness;mindfulness-based stress reduction;Music;Native-Born;neglect;Nonpharmacologic Therapy;Nurses;Operative Surgical Procedures;Opiate Addiction;Pacific Northwest;Pain;Pain intensity;Pain interference;Pain management;Pain Measurement;pain reduction;Participant;Pathway interactions;peer;perceived discrimination;Persons;Phase;pilot trial;Population;preference;Prevalence;Procedures;Process;programs;prototype;Psychologist;psychosocial;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Research Activity;Research Methodology;Resources;Risk;Sampling;satisfaction;Scientist;Sedation procedure;Series;Services;side effect;skill acquisition;skills;Social Workers;Spirituality;standard of care;Suicide;Surveys;Techniques;telehealth;Testing;therapy development;Training;Training Activity;Trauma;treatment adherence;treatment as usual;tribal community;Tribes;Unemployment;United States;United States Indian Health Service;United States National Institutes of Health;Universities;Washington;Yakama Indian

PROJECT_TITLE: Culturally Adapted Pain Management for Indigenous Peoples in the Pacific Northwest (CAP-I)


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: COLUMBIA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Autism affects up to 1.6% of the pediatric population, and can result in significant long term impairments. Autism is typically diagnosed after 2 to 3 years of age and there is a great need for improved early screening. This research is highly relevant to both early identification and intervention for children with autism. By utilizing state of the art methods for the assessment of infant cry and neurobehavior, this project seeks to develop a screening tool/process that can be used in the first year of life. This research work has the potential to open new doors for early intervention and will lead to an improved understanding of the early developmental course of autism.

PI_NAMEs: SHEINKOPF, STEPHEN J (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: 2 year old;3 year old;Acoustics;Address;Affect;Age Months;Arousal;Autism Diagnosis;autism spectrum disorder;autism symptoms;autistic children;biobehavior;Birth;Characteristics;Child;Child Development;Childhood;Classification;cohort;Complex;computerized;Crying;Data;detection method;Development;Developmental Course;Diagnosis;Diagnostic;Disease Progression;early childhood;Early identification;Early Intervention;early screening;Enrollment;Evaluation;Family;Family member;follow-up;Functional disorder;Genetic;high risk infant;Hospitals;Impairment;improved;infancy;Infant;Life;Link;Long-Term Effects;Measures;Methods;model building;Modeling;Modernization;Movement;Neonatal;neonatal period;neurobehavior;neurobehavioral;Neurodevelopmental Deficit;Newborn Infant;novel;Outcome;Outcome Assessment;Parents;Population;predictive modeling;Predictive Value;Pregnancy;Prevention;Procedures;Process;Production;Property;Public Health;Publishing;Recording of previous events;recruit;Registries;Regulation;Research;response;Rhode Island;Risk;Risk Marker;Sampling;screening;Screening procedure;Series;Siblings;signal processing;Signal Transduction;Statistical Models;Stress;success;Systems Analysis;Technology;Testing;tool development;Validation;Woman;Work

PROJECT_TITLE: Neonatal Cry Acoustics and Neurobehavioral Characteristics as Early Markers of Risk for Autism Spectrum Disorder


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Epilepsy;Health Services;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Stroke

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Anticonvulsants are commonly prescribed to older adults after stroke to prevent seizures, but these drugs may not be necessary or the harms could outweigh the benefits. There is limited rigorous evidence guiding when and how physicians should prescribe this type of treatment. This project will use the real-world experience of millions of Medicare beneficiaries to generate this evidence and inform both policy and future clinical decisions.

PI_NAMEs: MOURA, LIDIA MARIA VERAS ROCHA DE (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Academy;Acute;acute stroke;Address;adjudication;Adverse effects;Adverse event;adverse event risk;Advisory Committees;aged;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;American;American Heart Association;analytical tool;Anticonvulsants;beneficiary;Case Series;Clinical;clinical care;Clinical Management;Clinical Trials;Communities;comorbidity;comparative safety;Complex;Complication;cost;Cox Proportional Hazards Models;Data;Data Set;dementia care;Detection;Diagnosis;Drug Labeling;Drug usage;Electroencephalography;electronic health data;Electronic Health Record;Eligibility Determination;Emergency department visit;Enrollment;Epilepsy;epileptiform;Etiology;Event;experience;fall injury;falls;Family;Fee-for-Service Plans;follow-up;Foundations;Future;Guidelines;high risk;Hospitalization;human old age (65+);improved;Incentives;Individual;individualized medicine;Ischemic Stroke;Life;Link;Literature;machine learning method;Measures;Medicare;Medicare claim;Medicare Part A;Methods;Modeling;multidisciplinary;Names;National Committee for Quality Assurance;Neurology;novel;Observational Study;older adult;Outcome;Outpatients;Patient Care;Patients;Pattern;Pharmaceutical Preparations;Physicians;Policies;Policy Maker;population based;Positioning Attribute;post stroke;predictive modeling;Predisposition;prevent;programs;Prophylactic treatment;Provider;randomized trial;recruit;Registries;Relative Risks;Risk;Safety;safety study;Sampling;Scoring Method;Seizures;Serious Adverse Event;Severities;Stroke;stroke event;stroke risk;stroke survivor;Symptoms;Therapeutic;Time;treatment duration;trial comparing;Uninsured Medical Expense;Validation;validation studies

PROJECT_TITLE: Comparative Safety of Seizure Prophylaxis within the Medicare Program

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Organ Transplantation;Transplantation

PHR: Project narrative Demand for heart transplant in the United States far exceeds the supply of donor organs and as a result, nearly 500 patients die annually while awaiting a donor heart. The proposed study will establish the feasibility and benefits of strategies to narrow the gap between donor heart supply and demand, thereby reducing waiting times and improving survival. Such strategies will include 1) reducing the discard of sub-optimal but still viable donor hearts and 2) identifying and removing from the waitlist patients who would fare better with alternative treatments (in lieu of transplant).

PI_NAMEs: WAYDA, BRIAN  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Adopted;alternative treatment;Antibodies;Behavior;Blood;career;Career Mobility;Characteristics;Clinical;cohort;Country;data registry;design;Disparity;disparity reduction;Europe;European;experience;Geographic Locations;Grant;Heart;Heart failure;Heart Transplantation;high risk;Home;improved;improved outcome;Institution;interest;Logistic Regressions;Measures;mechanical device;Medical;Medical Device;Mentorship;Modeling;models and simulation;mortality;Organ;Organ Donor;Outcome;patient subsets;Patients;Phenotype;Physicians;Population;post-transplant;Research;Research Personnel;Resources;Risk;Scheme;Series;simulation;skills;Testing;Training;Training Activity;Translating;transplant centers;Transplantation;United States;Universities;validation studies;Variant;Wait Time;Waiting Lists;Work

PROJECT_TITLE: Narrowing the gap between supply and demand in heart transplantation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-A(20)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative The proposed research is highly relevant to public health because it addresses the critical challenge of reducing therapeutic resistance in breast cancer. This study is expected to advance the mechanistic understanding on the IFN1-induced cancer cell resistance to therapy, as well as identify a potential novel therapeutic target, ARID4B. This knowledge will inform the development of new medical interventions to treat breast cancer.

PI_NAMEs: WU, MEI-YI  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Ablation;Address;Adjuvant Radiotherapy;Affect;antitumor effect;ARID Domain;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;breast cancer progression;breast cancer survival;Breast Cancer Treatment;cancer cell;cancer therapy;cancer type;carcinogenesis;CEB1 Gene;Cells;chemotherapy;Chemotherapy and/or radiation;chromatin remodeling;Clinical;clinical efficacy;Data;Development;DNA Damage;DNA Repair;Excision;Family;Genes;genetic signature;hormone therapy;Human;Immune;immunoregulation;improved;in vivo;innovation;Interferon Activation;Interferon Type I;Interferons;Intervention;irradiation;ISG15 gene;Knock-in Mouse;Knock-out;Knowledge;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Medical;mouse model;new therapeutic target;novel therapeutic intervention;Oncogenic;Operative Surgical Procedures;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;pre-clinical;Proteins;Public Health;Regulation;Regulatory Pathway;Relapse;Research;Resistance;Resistance development;response;restraint;Role;Signal Pathway;Signal Transduction;standard care;STAT1 gene;Testing;theories;Therapeutic;therapy development;therapy resistant;Treatment Efficacy;tumor;tumor progression;tumorigenesis

PROJECT_TITLE: Regulation of Type I Interferon Pro-tumor Effects in Breast Cancer

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Lung;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Sleep Research;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The proposed study provides an unprecedented opportunity to expand a study of sleep to include important clinical and geriatric outcomes of falls and fractures. A simple home-based approach for identifying modifiable sleep characteristics was implemented in 4959 women who are already being followed for cardiovascular, cancer and cognitive outcomes. Extension of the study to include additional outcomes of falls and fractures is a cost-efficient opportunity to substantially expand our understanding of the impact of sleep disturbance on the health of older persons.

PI_NAMEs: CAULEY, JANE ANN (contact);CRANDALL, CAROLYN JANET

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: actigraphy;adjudication;Age;age related decline;Attention;Biological;Cardiovascular Diseases;Cardiovascular system;Characteristics;Circadian Dysregulation;Circadian Rhythms;Clinical;clinically relevant;Cognitive;cost;cost efficient;Data;Death Rate;Diet;Elderly;Enrollment;experience;fall risk;falls;follow-up;Fracture;gender difference;Goals;Health;healthy aging;High Prevalence;Hip region structure;Home;humerus;hypnotic;Hypoxemia;Hypoxia;Impaired cognition;improvement on sleep;Intervention;Malignant Neoplasms;Measures;Medicare;meetings;men;Minority;modifiable risk;nocturnal Hypoxemia;Observational Study;Obstructive Sleep Apnea;older adult;older men;Older Population;older women;osteoporosis with pathological fracture;Outcome;Oxygen;Oxygen saturation measurement;Participant;Pharmaceutical Preparations;Physical activity;Polysomnography;poor health outcome;poor sleep;Prevalence;primary outcome;prospective;Prospective Studies;recruit;Recurrence;Reporting;resilience;Rest;Risk;Risk Factors;Role;Safety;secondary outcome;sex;Sex Differences;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;Sleeplessness;Testing;Time;Vertebral column;Woman;women versus men;Women's Health;Wrist

PROJECT_TITLE: Sleep, Falls and Fractures in men and women:  Role of nocturnal hypoxia

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Social Determinants of Health

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE In the U.S., heat is responsible for more fatalities than all other weather events and the burden of morbidity and mortality attributable to heat is expected to grow in coming decades, particularly in Southern communities, such as New Orleans. The relationship between heat and health is context-specific and local data can be used to inform heat preparedness activities. The proposed project will estimate the health burden of heat in New Orleans and identify individual and neighborhood characteristics, as well as behavior patterns, that increase vulnerability to heat.

PI_NAMEs: MADRIGANO, JAIME  (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Adult;Attention;attributable mortality;Behavior;Behavioral;Cessation of life;Characteristics;Child;Cities;Climate;climate adaptation;climate data;Collaborations;Color;Communities;community advisory board;community engagement;community intervention;community research;Consultations;Data;Data Sources;Dedications;Development;Ecological momentary assessment;Effectiveness;Elderly;Environment;Epidemiology;Evaluation;Event;experience;Exposure to;extreme heat;Face;Fatigue;hazard;Health;Health Care Costs;health equity;Health Personnel;Healthcare;Heat Stress;Home;Hospitalization;Hot Spot;Housing;Human;Humidity;improved;indexing;Individual;indoor concentrations;Infrastructure;innovation;Insurance Claim Review;Intervention;Life;Life Cycle Stages;Louisiana;Low income;Measurement;Measures;Methods;Microclimate;Morbidity - disease rate;mortality;Neighborhoods;novel;Outcome;Pattern;Persons;Play;Policies;Policy Maker;Population;Poverty;Prevalence;Procedures;Process;Production;Public Health;public health intervention;Readiness;Recommendation;Research;Resource Allocation;Resources;response;Risk;risk perception;Role;sleep quality;social media;Source;Symptoms;System;Temperature;Time;Translating;Translational Research;trend;United States;Walking;Weather;Work

PROJECT_TITLE: NOLA HEAT-MAP: New Orleans Home, Environment, and Ambient Temperature: Measurements and Analysis for Preparedness

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ORG_CITY: MATHER

ORG_NAME: VA NORTHERN CALIFORNIA HEALTH CARE SYS

PHR: Record numbers of Veterans are pursuing higher education. However, difficulties with attention, memory, irritability, and self-regulation often ‘derail’ Veterans with traumatic brain injury, post-traumatic stress and related issues as they pursue academic and life goals. Increasing engagement with rehabilitation amongststudent Veterans is a top priority, as access, stigma, and competing life demands often limit their use of traditional VA services. Innovations in treatment formulation and delivery that cross gaps between healthcare and education may be required to betterengage these Veterans. In this project, we will (a) assess the feasibility and acceptability of delivering remote cognitive interventions to improve cognitive-emotional regulation or education to optimize brain functioning for student Veterans; (b) characterize critical aspects of the training process, and (c) explore student insights on ways to further improve cognitive trainings to best meet their needs. This project will inform Veteran-centered care by tailoring interventions to the specific needs of student Veterans in a larger study.

PI_NAMEs: CHEN, ANTHONY  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Admission activity;Age;Attention;Award;Behavior;Behavioral;beneficiary;Brain;brain health;Caring;Chronic;Clinical Trials;Cognitive;cognitive rehabilitation;cognitive training;Collaborations;college;community reintegration;comorbidity;Data;design;digital;digital applications;Education;Educational Intervention;emotion dysregulation;emotion regulation;Emotional;emotional functioning;emotional symptom;Empirical Research;Enrollment;expectation;experience;Faculty;falls;Family;Feedback;Formulation;Foundations;Frustration;Future;Goals;Health education;health knowledge;Health Services Accessibility;Healthcare;higher education;implementation intervention;improved;Informal Social Control;innovation;insight;interest;Intervention;Interview;Investigation;K-Series Research Career Programs;Label;Learning;learning engagement;Learning Skill;Life;lifestyle factors;Location;Memory;mental health counseling;Modification;Nervous System Trauma;Neurobehavioral Manifestations;Neurocognitive;neurological rehabilitation;novel;novel strategies;online course;online resource;Parents;Participant;Pathologic;Patients;post 9/11;post-traumatic stress;Post-Traumatic Stress Disorders;preference;Process;programs;Provider;psychoeducation;Recording of previous events;recruit;Regulation;Rehabilitation therapy;remote delivery;Research;Schools;Secondary Schools;Services;skills;skills training;social stigma;Special Population;statistics;Structure;Students;success;Surveys;System;Task Performances;Technology;telecoaching;telerehabilitation;Testing;theories;therapy design;therapy development;Time;tool;Training;Traumatic Brain Injury;Veterans;Work

PROJECT_TITLE: Strengthening neuro-cognitive skills for success in school, work and beyond


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Nutrition;Obesity;Uterine Cancer;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Obesity is associated with increased risk of developing and succumbing to endometrial cancer (EC), with ~60% of EC patients being obese. We hypothesize that gyn-onocologists may be under-dosing obese EC patients treated with monoclonal antibodies (mAbs), such as atezolizumab, inadvertently decreasing their potential treatment efficacy in this obesity-modulated cancer, due to differences in the mononuclear phagocyte system (MPS) between obese and non-obese women. Thus, our goals are 1) to establish in this phase 1 trial the pharmacokinetics/pharmacodynamics (PK/PD) and the safe maximum tolerated dose (MTD) of atezolizumab + ONC201 in combination as an innovative promising treatment for EC, with expectation that higher dosing of atezolizumab will be required for obese women; 2) use the results and MTDs of these phase 1 trials to design future phase 2 clinical trials; and 3) create new biomarkers and strategies to individualize therapy of this unique atezolizumab/ONC201 combination that could be expanded in application to other immuno-oncology agents used to treat obese patients with EC or other cancer types.

PI_NAMEs: BAE-JUMP, VICTORIA LIN (contact);ZAMBONI, WILLIAM C

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: antagonist;Antigen-Presenting Cells;antitumor effect;Biological Markers;Blood;cancer cell;Cancer Patient;cancer type;CCL2 gene;CD32 Antigens;Cells;Cessation of life;chemokine;Clinical;Clinical Trials;clinically relevant;cohort;cytokine;design;Dopamine Receptor;dosage;Dose;Drug Kinetics;Endocrine system;Endometrial Carcinoma;Enrollment;Environment;expectation;Fatty Acids;FCGR3B gene;Funding;Future;Generations;Goals;Hormonal;Hormones;IgG Receptors;Immune;immune checkpoint;Immunooncology;individualized medicine;Induction of Apoptosis;Inflammatory;inhibitor;Innate Immune System;innovation;Institution;Ligands;Link;lipid metabolism;Malignant Neoplasms;Maximum Tolerated Dose;Measures;Mediator;Metabolic;Metastatic/Recurrent;Microsatellite Instability;Molecular;Monoclonal Antibodies;monocyte;Mononuclear;mouse model;Mus;Natural Killer Cells;Non obese;novel;obese patients;Obesity;obesity treatment;Pathway interactions;Patients;Phagocytes;Phagocytosis;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Pharmacology Study;phase 1 study;phase 2 designs;phase 2 study;Phase I Clinical Trials;phase I trial;Phase II Clinical Trials;Plasma;Predisposition;programmed cell death ligand 1;programmed cell death protein 1;Progression-Free Survivals;Proteins;RANTES;Reactive Oxygen Species;Regimen;response;Risk;Safety;Serum;small molecule;System;T-Cell Activation;Testing;Therapeutic;Thinness;TNF gene;TNFSF10 gene;Treatment Efficacy;tumor;tumor microenvironment;Up-Regulation;uptake;Uterine Neoplasms;Woman

PROJECT_TITLE: Impact of Obesity on Immuno-Oncology Agents in Endometrial Cancer


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative Hypoxia, a stress factor is commonly associated with poor prognosis of solid tumors, such as breast cancer. Our striking observation revealed that tumor cells in chronic hypoxia show a remarkably active RNA Pol I and ERK signaling. Our studies will investigate a novel strategy to debilitate the stress response of the nucleolus in hypoxia to curb metastatic progression of breast cancer.

PI_NAMEs: SAMANT, RAJEEV S (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Adopted;Animal Experiments;Binding;Biogenesis;biological adaptation to stress;Breast Cancer Cell;breast cancer metastasis;breast cancer progression;cancer cell;cancer survival;Cell Hypoxia;Cell Nucleolus;Cell Survival;Cells;Chronic;Dependence;design;Disease;Disease Progression;Dominant-Negative Mutation;Drug resistance;Ensure;Event;experience;Extracellular Signal Regulated Kinases;FDA approved;Genetic Transcription;Homeostasis;Hypoxia;Hypoxia Inducible Factor;In Vitro;in vivo evaluation;innovation;Invaded;kinase inhibitor;Licensing;Literature;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Messenger RNA;Metastatic breast cancer;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;Outcome;Oxygen;Phosphorylation;Pol1 Transcription Initiation Complex Proteins;pre-clinical;Process;Prognosis;programs;Proliferating;Proteins;Proteome;Publications;Publishing;Reaction;Research Project Grants;Resistance;response;Ribosomal DNA;Ribosomal Proteins;Ribosomal RNA;Ribosomes;RNA Polymerase I;RNA, Ribosomal, 28S;Signal Transduction;Site;Solid Neoplasm;sound;Stress;stressor;Supporting Cell;Testing;therapeutic target;therapy resistant;tool;Transcription Coactivator;Translating;Translations;tumor;Tumor Expansion;tumor growth;tumor hypoxia;tumor progression;Tumor Tissue;Work

PROJECT_TITLE: A novel strategy to debilitate breast cancer metastasis


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: ROOTSTOWN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NORTHEAST OHIO MEDICAL UNIVERSITY

ORG_STATE: OH

PHR: Osteoporosis is a major health care problem since approximately 10 million people over the age of 50 have been diagnosed with the disease and 33.6 million more are estimated to have low bone mass (osteopenia). TRAPPC9 is a novel protein in bone and the proposed studies will generate new information regarding its effects and mechanisms of action on bone cell development and function. Once we understand its full effects on bone and how it works to promote bone formation, this information will be helpful in developing new therapeutic strategies to selectively enhance bone formation in patients with clinically significant bone loss.

PI_NAMEs: SAFADI, FAYEZ F (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Actins;Adaptive Behaviors;Age;Albers-Schonberg disease;Appearance;autosome;Binding;Binding Proteins;bone;bone cell;Bone Diseases;bone loss;bone mass;Bone Resorption;Brain;brain abnormalities;cathepsin K;clinically significant;Complex;conditional knockout;cytokine;Data;Development;Diagnosis;diagnostic development;diagnostic tool;Disease;experimental study;Face;Family;General Population;Genes;Healthcare;In Vitro;in vivo;Intellectual functioning disability;knock-down;Knockout Mice;Knowledge;L-Plastin;Link;LoxP-flanked allele;Mediating;Mediator;Modality;Molecular;Mus;Muscle hypotonia;Mutation;Myelogenous;NF-kappa B;Nonsense Mutation;novel;novel therapeutic intervention;Osteitis;osteoclastogenesis;Osteoclasts;Osteogenesis;Osteolysis;Osteopenia;Osteoporosis;particle;Pathway interactions;Patients;Persons;Phenotype;Phosphotransferases;Physiological;Physiology;Play;Prevalence;protein transport;Proteins;Role;severe intellectual disability;Signal Pathway;Signal Transduction;skeletal;skeletal abnormality;Skeletal Development;skeletogenesis;Testing;therapeutic development;therapeutic target;trafficking;Transgenic Mice;Vesicle;Work

PROJECT_TITLE: The Role of TRAPPC9 in Osteoclast Differentiation and Function

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative The proposed research is relevant to public health because it will not only reveal critical molecular insights into the role of ARID1A mutation in cancer and particularly ovarian cancer, but also provide a scientific rationale for developing urgently needed new pre-clinical therapeutic strategies for this disease. These studies will also serve as a prototype for other epigenetic therapeutic strategies for cancers with genetic alterations in other regulators of chromatin structure, a well-recognized feature of many cancer types. Therefore, the proposed research is relevant to NIH’s mission in terms of developing fundamental knowledge that will reduce the burden of human illness.

PI_NAMEs: ZHANG, RUGANG  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: anti-PD-L1;anti-PD-L1 antibodies;anti-PD-L1 therapy;ARID1A gene;Aspartate;cancer cell;Cancer Model;cancer subtypes;cancer type;Catalytic Domain;Cells;chemotherapy;Chromatin Remodeling Factor;Chromatin Structure;Clinical;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;cytotoxic CD8 T cells;Data;Dependence;Diagnosis;Disease;DNA biosynthesis;effective therapy;Epigenetic Process;Epithelial ovarian cancer;experimental study;FDA approved;feature detection;Genetic;Genetic Transcription;Glutaminase;Glutamine;Goals;Granzyme;Growth;Human;human model;immune cell infiltrate;immune checkpoint blockade;Immunocompetent;Immunocompromised Host;in vivo;inhibitor;innovation;insight;Intervention;Knock-out;Knowledge;LoxP-flanked allele;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Methods;Mission;Modality;Molecular;mouse model;Mus;mutant;Mutate;Mutation;novel therapeutic intervention;Nucleotide Biosynthesis;nucleotide metabolism;Ovarian Clear Cell Tumor;Ovarian Endometrioid Adenocarcinoma;patient derived xenograft model;Platinum;pre-clinical;Prognosis;prototype;PTPRC gene;Public Health;Refractory;Repression;Research;Role;SMARCA4 gene;T-Cell Proliferation;Testing;Therapeutic;tumor;tumor microenvironment;Tumor Suppressor Proteins;United States National Institutes of Health;Up-Regulation;Xenograft Model

PROJECT_TITLE: Metabolic basis of ARID1A-mutated ovarian cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: Veterans who experience a significant cardiac event (surgery, stent placement, heart attack) qualify for cardiac rehabilitation, which is associated with clear benefits in improving health and survival. Unfortunately, enrollment and participation in cardiac rehabilitation is approximately 10%. Many VA sites use home-based cardiac rehabilitation in order to provide greater access to Veterans. There is major potential to improve Veteran engagement in home-based cardiac rehabilitation by using digital health technology in order to provide social support, which is a critical component for engagement. In our clinical trial, we will compare home-based cardiac rehabilitation alone (usual care) versus home-based cardiac rehabilitation plus digital coaching. Digital coaching is considered as providing social support, education, feedback, and motivation through a private social networking group and text messaging. We will examine group differences in cardiac rehabilitation participation, functional capacity, physical activity, psychosocial, clinical, and social cognitive outcomes.

PI_NAMEs: PARK, LINDA GRACE (contact)

PROJECT_TERMS: acceptability and feasibility;Activities of Daily Living;Address;Adherence;Adult;Behavioral;beneficiary;Cardiac;Cardiac rehabilitation;Cardiology;Cardiovascular system;Clinical;Clinical Trials;Cognitive;Collaborations;comparative efficacy;comparison control;connected care;Control Groups;Coronary;cost;depressive symptoms;Devices;digital;digital delivery;digital health;digital technology;Education;Eligibility Determination;Enrollment;Event;exercise training;experience;Feedback;fitbit;functional status;Funding;Future;Glycosylated hemoglobin A;Goals;group intervention;Health;Health Services Accessibility;Health Technology;Heart Diseases;Home;hospital readmission;improved;Individual;Informal Social Control;innovation;Intervention;intervention effect;Learning;Lipids;Mediating;Medicare;mental function;Methodology;mobile application;Modeling;Modernization;Modification;Morbidity - disease rate;mortality;Motivation;Multimedia;Myocardial Infarction;new technology;novel;Operative Surgical Procedures;Outcome;Outcome Assessment;Outcome Measure;participant enrollment;Patients;peer;Performance;Physical activity;Physical Function;Physical Performance;prevent;Prevention program;Privatization;programs;psychosocial;Psychosocial Assessment and Care;psychosocial outcome;Qualifying;Quality of life;Randomized;randomized, clinical trials;Recommendation;Rehabilitation Centers;rehabilitation service;revascularization;Risk;Rural;Rural Health;Secondary Prevention;sedentary;Self Efficacy;Self Management;Services;Site;social;Social Functioning;Social Network;Social support;Stents;tailored messaging;Technology;technology intervention;telehealth;telephone based;Testing;Text Messaging;theories;Time;Training;treatment as usual;valve replacement;Veterans;virtual;virtual healthcare;Walking;wearable device;Work

PROJECT_TITLE: Virtual Care Strategies to Improve Participation in Cardiac Rehabilitation among Veterans

STUDY_SECTION_NAME: HSR-3 Healthcare Informatics[HSR3]


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: Suicide is a national public health problem that disproportionately affects Veterans. However, the toll associated with suicide goes way beyond the death of an individual. This study addresses the problems that it is unknown how many Veterans need intervention following exposure to suicide, what types of problems should be addressed and what intervention approaches might be most beneficial. The primary objective of this study is to describe the health and functional outcomes of suicide exposure among a cohort of Veterans at particularly high risk for suicide and of priority for VA suicide prevention strategies – post-9/11 Veterans transitioning to civilian life. Our second objective is to elucidate the reasons some Veterans develop persistent problems following suicide exposure while others do not. This study starts with quantitative (which is the priority of the study) followed by qualitative data collection and analysis to explain and expand the quantitative findings. Findings can inform strategies to support Veterans affected by a suicide loss.

PI_NAMEs: SAYER, NINA A. (contact)

PROJECT_TERMS: Address;Affect;Alaska Native;American Indians;Attention;Buffers;Cessation of life;Characteristics;cohort;combat;comparison group;Data;Data Analyses;Data Collection;Death Rate;Diagnosis;Disease;effective therapy;Enrollment;Ethnic Origin;experience;Exposure to;Feeling suicidal;Foundations;functional outcomes;Grief reaction;healing;Health;health assessment;health care service;health care service utilization;Healthcare;high risk;Impairment;Individual;informal support;innovation;interest;Intervention;Interview;Knowledge;Lead;Life;Mental disorders;Mental Health;Methodology;Methods;Military Personnel;Outcome;Outcome Assessment;Pattern;Persons;Population;post 9/11;Post-Traumatic Stress Disorders;Prevalence;prevent;Prevention strategy;primary outcome;Probability;Probability Samples;Public Health;Race;racial diversity;racial minority;racial population;Recording of previous events;reducing suicide;Reporting;Research;research and development;Respondent;Risk;Risk Factors;Sample Size;Sampling;service member;service utilization;sex;Sex Differences;Social Functioning;social stigma;Social support;Sudden Death;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;Surveys;Target Populations;therapy development;Time;Trauma;Veterans;virtual;Woman;Work

PROJECT_TITLE: Exposure to Suicide Among Post 9/11 Veterans: Prevalence, Correlates and Treatment Needs

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


FUNDING_MECHANISM: OTHERS

ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

PHR: Dr. Kirsch’s research activities focus on restoring shoulder, arm, and hand movements to individuals with extensive paralysis due to spinal cord injury (SCI). SCI is a devastating condition that often causes significant disability and loss of independence. There are approximately 296,000 individuals in the United States with a SCI, at least 42,000 of whom are Veterans eligible for VA care. Dr. Kirsch has used functional electrical stimulation to elicit contractions in paralyzed muscles that can power movements, and novel control methods to coordinate these muscle contractions to generate functional movements. He has also examined cutting edge “brain computer interface” techniques to give the users of such a system the ability to intuitively command the desired movements of the upper limb. Dr. Kirsch is also very active in “translational research” programs that assist researchers in developing their laboratory discoveries into products that improve the independence and overall health of Veterans.

PI_NAMEs: KIRSCH, ROBERT F. (contact)

PROJECT_TERMS: Academia;Activities of Daily Living;Address;Algorithms;American;Amputees;Anatomy;Area;arm;arm movement;artificial intelligence method;Biomedical Engineering;Brain;brain computer interface;brain health;career;Caring;Cervical;Cervical spinal cord injury;Characteristics;Clinical;combat injury;Communities;design;Development;disability;Doctor of Philosophy;Education;Elbow;Electrodes;Eligibility Determination;Engineering;Faculty;first-in-human;functional electrical stimulation;functional restoration;Funding;Hand;Health;Healthcare;Human;Human Resources;improved;Incidence;Individual;Injury;Intervention;Intuition;Journals;K-Series Research Career Programs;Laboratories;Leadership;Learning;Medical;member;Mentors;Methods;Military Personnel;Modeling;Movement;Muscle;Muscle Contraction;Muscle function;Musculoskeletal;Neck;Nerve;Nervous System Disorder;neural;neural implant;neural network;neuroregulation;neurorestoration;neurotechnology;novel;Orthotic Devices;Pain;Paralysed;Participant;Pattern;Persons;Population;programs;Prosthesis;prosthesis control;Proxy;Psychological reinforcement;Publications;Quadriplegia;rehabilitation research;Rehabilitation therapy;Research;Research Activity;research and development;Research Personnel;Research Project Grants;restoration;Role;Scientist;Seminal;Series;Services;Shoulder;Signal Transduction;simulation;Skeletal Muscle;Spinal Cord;Spinal cord injury;Study Section;symposium;System;Techniques;Training;Translational Research;translational research program;Translations;undergraduate student;United States;United States National Institutes of Health;Universities;Upper Extremity;Upper limb movement;Veterans;Work

PROJECT_TITLE: RR&D Research Career Scientist Application

STUDY_SECTION_NAME: Research Career Scientist[RRD7]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Pediatric;Primary Immunodeficiencies;Psychosis;Rare Diseases;Schizophrenia;Serious Mental Illness

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: RELEVANCE: Psychosis is a debilitating psychiatric condition. Greater understanding of how abnormalities in neural development lead to dysfunction during youth and produce symptoms of psychosis or psychosis risk may be critical for the conceptualization of earlier and more effective treatments. This would benefit public health by reducing the great costs of psychosis to individuals and society at large.

PI_NAMEs: ROALF, DAVID R (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: 22q11.2;3-Dimensional;Acoustic Rhinometry;associated symptom;behavior measurement;Behavioral;Biometry;Body part;brain dysfunction;Brain region;Characteristics;Classification;clinical high risk for psychosis;clinically relevant;cohort;cost;Craniofacial Abnormalities;Data;Development;DiGeorge Syndrome;Dimensions;Distress;Dysmorphology;Ear;effective therapy;Etiology;Event;Exhibits;Eye;Face;feature selection;Functional disorder;functional outcomes;Genetic Diseases;genetic disorder diagnosis;Genetic Risk;Geometry;Head;Human;Image;Impaired cognition;Impairment;improved;Individual;innovation;Lead;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Mandible;Measures;medial temporal lobe;Mental disorders;microdeletion;Minor;Modeling;Monosomy 21;Morphology;multilevel analysis;Nasal cavity;Neurobiology;neurodevelopment;neuromechanism;neuropathology;Nose;Odors;olfactory bulb;Olfactory Cortex;Olfactory Pathways;olfactory sulcus;Oral cavity;Patients;Performance;Peripheral;Phenotype;precision medicine;Process;Psychiatry;Psychophysics;Psychoses;psychosis risk;Psychotic Disorders;psychotic symptoms;Public Health;Research;resilience;Risk;Sampling;Schizophrenia;Severities;Smell Perception;Societies;Structural defect;structural imaging;Structure;Symptoms;Syndrome;Techniques;Testing;Three-Dimensional Imaging;trait;Work;Youth

PROJECT_TITLE: Olfactory and facial markers of developmental risk for psychosis in 22q11 deletion syndrome

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE The DIAN-TU Primary Prevention Trial is a clinical trial that will test if Alzheimer's disease can be prevented by starting an anti-amyloid therapy at the earliest stages of the disease. It is a 4 year double blind, randomized placebo-controlled study of anti-amyloid based therapies in individuals at risk of dominantly inherited Alzheimer's disease that are enrolled at a point when they have evidence of little to no amyloid plaques as measured by PET scan. The results of this study will have substantial public health benefits by testing if Alzheimer disease can be prevented by stopping amyloid pathology from developing.

PI_NAMEs: MCDADE, ERIC MARTIN (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: abeta accumulation;abeta deposition;Abeta synthesis;Address;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Amyloid deposition;amyloid pathology;Amyloidosis;arm;beta amyloid pathology;Biological Markers;blind;Blinded;cerebral atrophy;Clinical;Clinical Trials;Cognitive;cognitive benefits;comorbidity;Consensus;Country;Dementia;design;Detection;Development;Disease;Disease Progression;Double-Blind Method;Down's Syndrome;Early Onset Alzheimer Disease;effective intervention;effective therapy;Enrollment;Evolution;Foundations;Funding;Future;Gene Proteins;Goals;Grant;Health;Health Benefit;Impaired cognition;Individual;Infrastructure;Inherited;Intervention;Language;Measures;Mutation;mutation carrier;neuron loss;Neuronal Dysfunction;operation;Outcome Study;Participant;Pathologic;Pathology;Pharmaceutical Preparations;Phase;Placebo Control;Placebos;Population;Positioning Attribute;Positron-Emission Tomography;prevent;Prevention;prevention clinical trial;Prevention trial;Primary Prevention;Prior Therapy;Production;Public Health;Randomized;randomized placebo controlled study;Risk;Role;Secondary Prevention;Senile Plaques;Site;success;Symptoms;tau Proteins;tau-1;Testing;Therapeutic;Therapeutic Intervention;Therapeutic Trials;Time;treatment arm;Uncertainty;Vulnerable Populations;Work

PROJECT_TITLE: DIAN-TU Primary Prevention Trial


NIH_SPENDING_CATS: Digestive Diseases;Nutrition;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE The goal of this project is to identify how the nutrient-sensing cell of the intestine, the enteroendocrine cell, may signal changes in nutrient availability to other cells within the gut. This has significant implications for how changes in dietary intake or pharmacological manipulation of enteroendocrine peptides may influence the capacity for regeneration, nutrient absorption, and overall metabolic health. With the staggering rates of metabolic and digestive disease in the United States, understanding how enteroendocrine cells regulate gut function is a pressing public health concern.

PI_NAMEs: MCCAULEY, HEATHER A (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: 5'-AMP-activated protein kinase;Affect;Biochemistry;Biological Assay;Biological Models;blood glucose regulation;Brain;Carbon Dioxide;Cell Communication;Cell Line;cell type;Cells;Communities;Community Physician;Coupled;Data;detection of nutrient;Development;Developmental Biology;Diarrhea;dietary;Dietary intake;Digestion;Digestive System Disorders;Distress;Electrophysiology (science);Endocrinology;Ensure;Enterocytes;Enteroendocrine Cell;Environment;Epithelial Cells;Epithelium;Exhibits;experimental study;Fluorescence;FRAP1 gene;G-Protein-Coupled Receptors;Gastroenterology;gastrointestinal;Genetic Transcription;Genus Hippocampus;Goals;gut health;Health;Home;hormonal signals;Hormones;Human;human model;Hunger;Image;Individual;Ingestion;innovation;Institution;insulin secretion;International;intestinal epithelium;intestinal homeostasis;Intestines;Ions;large scale production;Link;Mass Spectrum Analysis;Measures;Medical center;Medicine;Mentors;Metabolic;Metabolic Diseases;metabolic rate;Metabolism;metabolomics;Mitochondria;Motility;mouse model;Mus;Mutation;National Institute of Diabetes and Digestive and Kidney Diseases;Nausea;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nutrient;nutrient absorption;Nutrient availability;nutrition;Organ;Organoids;Pancreas;Paneth Cells;paracrine;Parenteral Nutrition;Pathway interactions;Patients;Pediatric Hospitals;Pediatric Research;Peptide Signal Sequences;Peptides;pharmacologic;Physiology;Play;Pluripotent Stem Cells;Production;Proliferating;Public Health;Receptor Cell;Regenerative capacity;Regulation;Reporter;Research;Research Personnel;Respiration;response;Role;Satiation;Schedule;Scientist;Second Messenger Systems;Signal Transduction;single cell analysis;single-cell RNA sequencing;Small Intestines;stem cell function;stem cell niche;stem cells;success;System;Testing;Time;Tissues;Training;training opportunity;transcription factor;United States;United States National Institutes of Health;uptake;Vomiting;Work

PROJECT_TITLE: Enteroendocrine Regulation of Intestinal Metabolism

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Comparative Effectiveness Research;Disability Research;Neurosciences;Physical Rehabilitation;Precision Medicine;Rehabilitation;Stroke

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Arm strength is important for taking care one’s self. Predicting whether arm weakness due to a stroke will or will not improve would allow for more efficient and effective testing of new treatments, and more individualized treatment decisions. The VERIFY study will establish the ability of noninvasive transcranial magnetic stimulation and MRI to reliably predict patient outcomes in the important, early period of stroke recovery.

PI_NAMEs: CRAMER, STEVEN C.;KHATRI, POOJA  (contact);STINEAR, CATHY ;VAGAL, ACHALA SAMEER

PROGRAM_OFFICER_NAME: AFZAL, MARIAM MASHEEB

PROJECT_TERMS: Action Research;Acute;acute stroke;Address;Affect;arm;Biological Markers;biomarker validation;Caring;Categories;Cerebral hemisphere hemorrhage;Classification;Clinical;clinical practice;Clinical Treatment;clinically relevant;cohort;Corticospinal Tracts;cost;Data;Data Set;Decision Making;Dimensions;disability;Enrollment;Fiber;functional outcomes;Future;Health;Hospitalization;Impairment;improved;Individual;individual patient;individualized medicine;Injury;innovation;International;international health organization;Ischemic Stroke;Lesion;Location;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Motor;Motor Activity;Motor Cortex;motor deficit;Motor Evoked Potentials;motor impairment;motor recovery;neuroimaging;neurophysiology;Outcome;outcome prediction;Patient Selection;patient stratification;patient subsets;Patient-Focused Outcomes;Patients;Performance;Physiological;post stroke;predictive tools;prevent;primary outcome;Process;prognostic;prospective;Randomized, Controlled Trials;Recommendation;Recovery;Rehabilitation therapy;Reperfusion Therapy;Reporting;Research;Residual state;response;Sampling;Severities;Site;Stroke;stroke recovery;stroke rehabilitation;stroke survivor;System;Testing;Transcranial magnetic stimulation;treatment effect;Triage;Upper Extremity;Validation;World Health Organization

PROJECT_TITLE: Validation of Early Prognostic Data for Recovery Outcomes after Stroke for Future, Higher Yield Trials (VERIFY)


NIH_SPENDING_CATS: Aging;Anxiety Disorders;Brain Disorders;Cardiovascular;Clinical Research;Heart Disease;Hypertension;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Post-Traumatic Stress Disorder (PTSD);Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Adverse pregnancy outcomes and mental health conditions, such as posttraumatic stress disorder and depression, increase the risk of for cardiovascular disease in women. For some women, acute APOs (preeclampsia and preterm delivery) are also traumatic events that may precipitate the development of posttraumatic stress disorder (PTSD) and depression after pregnancy, but existing studies are limited. This research will utilize complementary data sources (prospective cohort studies, electronic health records, and qualitative interviews) to disentangle the complex relationships between APOs, mental health conditions, and cardiovascular disease across the life course, characterize the mental health sequelae following pregnancies complicated by preeclampsia or preterm delivery, and inform future strategies to reduce cardiovascular risk in women.

PI_NAMEs: STUART, JENNIFER JACQUELINE (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: 37 weeks gestation;Acute;Address;Admission activity;adverse pregnancy outcome;Articulation;barrier to care;Black race;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cessation of life;Chronic;Clinical Data;clinically relevant;Complex;Coronary heart disease;Cox Proportional Hazards Models;Data;Data Sources;Development;Diabetes Mellitus;Diagnosis;Electronic Health Record;Enrollment;Epidemiologist;epidemiology study;ethnic diversity;Event;experience;Female;Fetal Growth;follow-up;Foundations;Future;Goals;health care service utilization;Health system;healthy lifestyle;Hemorrhage;hypercholesterolemia;Hypertension;improved;infant outcome;insight;Interview;Joints;K-Series Research Career Programs;Life;Life Cycle Stages;Link;Literature;Machine Learning;machine learning method;Mediating;men;Mental Depression;mental development;Mental Health;Mentors;Mentorship;Methodology;National Heart, Lung, and Blood Institute;Neonatal Intensive Care Units;Non-Insulin-Dependent Diabetes Mellitus;normotensive;novel;Nurses' Health Study;Observational epidemiology;obstetrical complication;parous;Pathway interactions;Patient Recruitments;Patients;Population;Population Heterogeneity;Positioning Attribute;post pregnancy;Post-Traumatic Stress Disorders;Postpartum Period;Pre-Eclampsia;Predictive Factor;predictive modeling;Pregnancy;Pregnancy Complications;Premature Birth;prepregnancy;prevent;prospective;Prospective, cohort study;Psychiatric epidemiology;Qualitative Research;Questionnaires;Race;racial diversity;Recording of previous events;reproductive;reproductive epidemiology;Research;Research Personnel;resilience factor;Risk;Risk Factors;Risk Marker;risk prediction model;risk sharing;Role;Sampling;Science;screening;Secondary to;skills;Strategic vision;Stress Tests;Stroke;Structure;Techniques;Time;Training;Translating;Trauma;traumatic event;Woman;Women's cohort;Women's Health

PROJECT_TITLE: Female-Specific Risk Factors for CVD: The Impact of Adverse Pregnancy Outcomes on Subsequent Mental Health and CVD Risk

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Radiation Oncology;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative 90Y radiation lobectomy (90Y-RL) is a novel treatment paradigm for patients with unresectable HCC enabling both locoregional control of disease and may achieve adequate FLR hypertrophy for resection. The proposed project investigates the underlying mechanisms of the liver atrophy/hypertrophy complex following 90Y-RL using quantitative MR imaging and investigates the influence of radiation dose and glass bead embolic load on parenchymal dosimetry using non-FDG PET/CT. We hypothesize that 90Y-RL patient recurrence free survival will be similar to that of patients with HCC deemed to be surgical candidates at presentation.

PI_NAMEs: COLLINS, JEREMY DOUGLAS;LEWANDOWSKI, ROBERT J (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: 4D MRI;90Y;Acceleration;Angiography;Atrophic;Automobile Driving;Biodistribution;Biological Markers;Blood;Blood flow;Catheters;Cirrhosis;Clinical;Complex;contrast enhanced;curative treatments;Data;Diagnosis;disorder control;Dose;dosimetry;early detection biomarkers;efficacy evaluation;elastography;Excision;Fibrosis;Future;Glass;hemodynamics;Hepatic;Hepatic Tissue;Hepatology;Hypertrophy;Image Enhancement;imaging biomarker;improved;in vivo;Individual Adjustment;individual patient;Infusion procedures;innovation;Intervention;Lesion;Life;Literature;Liver;Liver diseases;Liver Failure;Liver Fibrosis;liver function;Liver parenchyma;liver stiffness;liver transplantation;Lobar;Lobectomy;Magnetic Resonance Imaging;Measurement;Methods;Microspheres;Multi-Institutional Clinical Trial;Multi-site clinical study;multidisciplinary;Nature;Neoplasm Metastasis;novel;Oncology;Operative Surgical Procedures;Organ;Outcome;patient population;Patients;Perfusion;PET/CT scan;Play;Portal Hypertension;Portal vein structure;Prediction of Response to Therapy;predictive marker;Primary carcinoma of the liver cells;Procedures;Prospective Studies;Radiation;Radiation Dose Unit;Radiation Fibrosis;Radiation Injuries;Radioembolization;recruit;Recurrence;response;risk minimization;Role;symposium;Techniques;Therapeutic Embolization;Time;Transplantation Surgery;treatment strategy;tumor;Tumor Tissue;Unresectable;Visualization

PROJECT_TITLE: Yittrium-90 radiation lobectomy: Dose optimization and prediction of FLR hypertrophy to enable resection of HCC

STUDY_SECTION: CMIP

STUDY_SECTION_NAME: Clinical Molecular Imaging and Probe Development[CMIP]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Limb malformations are the second most common congenital abnormality and are becoming increasingly linked to rare noncoding variants in transcriptional enhancers, short DNA sequences that activate gene expression. Yet, the disease mechanisms by which these rare noncoding variants disrupt normal limb development remain unclear. In this proposal, I will use novel transgenic mouse technology and single-cell epigenomics to determine the genetic factors mediating the unique susceptibility of limb-specific enhancers to pathogenic noncoding variants.

PI_NAMEs: HOLLINGSWORTH, ETHAN W (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: 3-Dimensional;Address;Affect;Anterior;Architecture;Binding;Biological Assay;Biological Models;Birth;Cell Culture Techniques;cell type;Cells;Chromatin;Chromatin Loop;Chromatin Structure;clinical predictors;clinically significant;cohesin;Competence;Congenital Abnormality;Data;Defect;Detection;developmental disease;Disease;disease phenotype;DNA;DNA Sequence;Ectopic Expression;Enhancers;epigenomics;gain of function;Gene Expression;Genes;Genetic;genetic risk factor;Genetic Transcription;Genomics;Germ Lines;Germ-Line Mutation;Goals;Higher Order Chromatin Structure;human disease;In Vitro;in vivo;insight;Knock-in Mouse;Lead;Limb Bud;Limb Development;Limb structure;Link;Live Birth;malformation;Maps;Mediating;Modeling;multiple omics;Mus;Mutation;novel;Nucleic Acid Regulatory Sequences;Organoids;Pathogenesis;Pathogenicity;Patients;Phenotype;Predisposition;promoter;rare variant;Reporter;Reporting;Reproducibility;Resolution;Role;SHH gene;superresolution microscopy;System;Technology;Testing;Tissues;transcription factor;Transgenic Mice;Untranslated RNA;Variant;Visualization

PROJECT_TITLE: Deciphering Mechanisms of Limb Malformations Caused by Noncoding Variants In Vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Nanotechnology;Ovarian Cancer;Radiation Oncology;Rare Diseases;Women's Health Research

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: NARRATIVE Ovarian cancer remains the most lethal gynecologic malignancy. The quality of surgery remains a primary predictor of survival. We propose a nanoparticle strategy to enable presurgical imaging, surgical imaging and surgical resection/destruction of ovarian tumors.

PI_NAMEs: KUNDRA, VIKAS  (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Abdomen;absorption;Animal Model;Cancer Model;chelation;chemotherapy;Clinical;clinical translation;Contrast Media;Data;Detection;detection method;Diagnosis;Dimensions;Disease;Dose;Excision;Eye;FDA approved;fluorophore;folate-binding protein;Gadolinium;Goals;Human;Image;Image-Guided Surgery;Immunotherapy;Implant;improved;In Vitro;in vivo imaging;Indocyanine Green;Injections;Integrin alphaVbeta3;intraperitoneal;Lesion;Light;Liposomes;Location;Magnetic Resonance Imaging;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Methods;Modeling;Multimodal Imaging;nanoparticle;nanoscale;Near-infrared optical imaging;Nodule;non-invasive imaging;novel;Operative Surgical Procedures;optical imaging;Ovarian;ovarian neoplasm;particle;Patients;Peritoneal Diseases;Permeability;phantom model;photodestruction;Photons;photothermal therapy;Prognosis;Publishing;PUVA Photochemotherapy;Qualifying;Radiation;Radiation therapy;Reactive Oxygen Species;Resected;residence;Resolution;Sensitivity and Specificity;Shapes;Signal Transduction;Staging;survival prediction;targeted imaging;Technology;Testing;theranostics;Time;Tissues;tumor;Visualization;Woman

PROJECT_TITLE: Multimodal Imaging and Therapy of Ovarian Cancer

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: NARRATIVE Breast cancer (BC) is the most commonly diagnosed cancer and cause of cancer mortality in Asian/Pacific Islander (API) and Hispanic women; BC mortality varies substantially by immigrant status but factors underlying these disparities are unknown. This study will examine the multilevel (neighborhood and individual) influence of social networks on health behaviors and BC outcomes in diverse women, focusing on immigrant API and Hispanic women. Evaluating the influence of social networks on health behaviors and BC survival is central to identifying factors underlying BC disparities in ethnically diverse immigrant women, particularly those factors underlying favorable BC outcomes despite socioeconomic disadvantage.

PI_NAMEs: KROENKE, CANDYCE H (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Affect;Alcohol consumption;Asian;Behavior;behavior change;behavior measurement;Behavioral;breast cancer diagnosis;Breast Cancer Risk Factor;breast cancer survival;California;cancer diagnosis;cancer epidemiology;Cancer Etiology;Characteristics;Chinese;cigarette smoking;Clinical;cohort;Complex;constriction;Consumption;Country;Dairying;Data;Death Rate;Diagnosis;Disparate;Disparity;ethnic disparity;ethnic diversity;ethnic minority;ethnic minority population;Ethnic Origin;Ethnic Population;Family;Frequencies;Friends;hazard;Health;Health behavior;health disparity;Heterogeneity;Hispanic;Hispanic Populations;Hispanic Women;Hour;Household;Immigrant;Immigration;improved;improved outcome;Individual;insight;Institution;Intake;Internet;Intervention;Lead;Life;Linguistics;Logistics;Malignant Breast Neoplasm;Mediating;Mexican;Modeling;mortality;mortality risk;Neighborhoods;Not Hispanic or Latino;Obesity;Outcome;Pacific Islander;Pathway interactions;Patient Self-Report;Pattern;Physical activity;Play;Population;Quality of life;Race;Recommendation;Recurrence;Research;Research Personnel;residence;resilience factor;Resources;Risk Behaviors;Risk Factors;Role;Smoking;Smoking History;social;social culture;social disparities;social factors;social influence;Social Network;Social Obligations;Social Processes;social relationships;socioeconomic disadvantage;soy;Stage at Diagnosis;Structure;survivorship;Techniques;tumor;western diet;White Women;Woman;women's diagnosis;Work

PROJECT_TITLE: Social networks and disparities in health behaviors and breast cancer outcomes in immigrant women

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Patient Safety

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE While individuals ≥65 years and older makeup 40% of all inpatient surgeries and suffer from significantly increased risk of morbidity and mortality, there are no specific strategies in place to optimize their surgical care to improve outcomes. The American College of Surgeons (ACS) Geriatric Surgery Verification Program (GSV) introduced 30 evidence-based standards to systematically improve surgical care and outcomes. This proposal will develop guided implementation science approaches to develop strategies to increase the systematic uptake of ACS GSV program to (1) guide successful implementation of GSV program that will improve the patient outcomes significantly while reducing costs and (2) support the further training of Dr. Sevdenur Cizginer in dissemination and implementation science to become an independent researcher in aging research to enhance the surgical care of older adults.

PI_NAMEs: CIZGINER, SEVDENUR  (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Address;Adoption;Aging;American College of Surgeons;Area;Arrhythmia;Award;career;career development;Caring;Clinical;clinical outcome measures;clinical practice;Clinical Research;Clinical Trials Design;clinically relevant;Cognition;Computerized Medical Record;Consolidated Framework for Implementation Research;cost;Data;data integration;Delirium;design;Development;dissemination science;effectiveness testing;effectiveness/implementation trial;Elderly;Enrollment;Epidemiology;evidence base;Evidence based practice;experience;falls;Feasibility Studies;Geriatric Assessment;Goals;Grant;Health Care Costs;Health Services Research;Hospital Costs;hospital readmission;Hospitals;human old age (65+);implementation evaluation;implementation outcomes;implementation science;implementation strategy;implementation trial;implementation/effectiveness;improved;improved outcome;Individual;Infrastructure;inpatient surgery;interdisciplinary collaboration;interest;Interview;Knowledge;Lead;Leadership;Length of Stay;Maintenance;medical complication;Methods;Morbidity - disease rate;mortality;multidisciplinary;novel;nutrition;older adult;older patient;Older Population;Operative Surgical Procedures;Orthopedics;Outcome;Outcome Measure;Patient Care;Patient-Centered Care;Patient-Focused Outcomes;Patients;Peer Review;Perioperative;Persons;Phase;Physician Executives;Pilot Projects;Population;post implementation;Postoperative Period;Prevention;Process;programs;prospective;Protocols documentation;Qualifying;Qualitative Research;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recovery;Research;Research Personnel;response;Rhode Island;Risk;Role;routine practice;Secure;skills;Specific qualifier value;Standardization;success;Surgical complication;Surgical Models;surgical research;Testing;theories;tool;Training;Universities;uptake;Urology;Work;young adult

PROJECT_TITLE: Optimizing care for older surgical patients: atheory-guided implementation science approach


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Prostate Cancer;Urologic Diseases

PHR: Project Narrative Magnetic resonance imaging plays an important role for staging of prostate cancer. We propose advances that permit quantitative and a more reliable assessment of prostate cancer. Potentially this will permit better diﬀerentiation of disease that is aggressive from disease that poses low risk of spreading.

PI_NAMEs: MAIER, STEPHAN E (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: Area;Biological Markers;Biopsy;cancer diagnosis;Clinical;Complex;contrast imaging;cost;Data;Development;Diagnosis;Diagnostic Imaging;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Economics;Exhibits;Fingerprint;Image;imaging modality;improved;Indolent;International;Investigation;Joints;Lesion;Link;Machine Learning;magnetic field;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Maps;Measurement;Measures;method development;Microscopic;Monitor;Nature;neural network;Noise;novel;novel strategies;Operative Surgical Procedures;participant enrollment;Patients;Performance;Physiologic pulse;Play;Process;Prostate;Protocols documentation;Qualitative Evaluations;Quality of life;quantitative imaging;Radical Prostatectomy;radio frequency;Recommendation;Relaxation;Reproducibility;Research;Resolution;Risk;Role;Scanning;Sensitivity and Specificity;Signal Transduction;Staging;System;Techniques;Testing;Time;Tissues;Training;Translating;Variant

PROJECT_TITLE: Development of Methods for a Simplified and Reliable Prostate Cancer MRI Exam

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Narrative Title: Infant atlas of brain perfusion This proposal will establish new age-specific population-averaged infant brain perfusion atlases and delineate the infant brain physiology-function and physiology-behavior correlations by optimizing a novel arterial spin labelling MR imaging technique. These atlases will serve as a clinical reference by providing normal distribution and variability of regional cerebral blood flow at multiple critical infant developmental stages as well as fill the knowledge gap of lacking fundamental infant brain physiological properties. The proposed project has a broad impact on detecting abnormality of brain disorders and conducting targeted early intervention to ameliorate functional or behavioral alteration related to perfusion changes.

PI_NAMEs: HUANG, HAO  (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;age related;Area;arterial spin labeling;Atlases;Behavior;Behavior assessment;behavior prediction;Behavioral;Blood;Blood flow;blood flow measurement;Brain;brain abnormalities;Brain Diseases;Brain Injuries;Brain region;Calibration;Cerebral Ischemia;Cerebrovascular Circulation;Clinical;cohort;Collaborations;cost;Cost Sharing;Data;Data Set;Dedications;Development;diagnostic screening;Disease;Early Intervention;Functional Magnetic Resonance Imaging;Funding;Goals;Growth;Human;Image;Imaging Techniques;Individual;infancy;Infant;interest;Knowledge;Label;Letters;life span;Magnetic Resonance Imaging;Magnetism;Maps;Measures;Metabolic;Methods;neonate;neuroimaging;Normal Statistical Distribution;novel;Pediatric Hospitals;Pediatric Research;Perfusion;Phase;Philadelphia;Physiological;Physiology;Population;predictive marker;prisma;Process;Prognostic Marker;Property;Protons;rate of change;recruit;Reproducibility;Research Personnel;Resolution;Resource Sharing;Resources;Rest;Sampling;Screening procedure;Site;Standardization;Stroke;Structure;System;Techniques;Testing;Time;Tracer;Water

PROJECT_TITLE: Infant Atlas of Brain Perfusion

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Nanotechnology;Pediatric;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: WINSTON-SALEM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Although young infants are highly susceptible to serious influenza disease, development of vaccines that can protect this population remains an unrealized goal. The objective of the current application is to identify a strategy that can improve the quality of the vaccine elicited immune response in this vulnerable population, especially with regard to the generation of antibody that can recognize multiple influenza strains.

PI_NAMEs: ALEXANDER-MILLER, MARTHA ANN (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 1 year old;adaptive immune response;Address;Adjuvant;Adult;Affinity;African Green Monkey;age group;Age Months;Agonist;Animal Model;Antibodies;Antibody Formation;Antibody Response;Antigens;Area;B cell differentiation;B-Lymphocytes;Biological Assay;booster vaccine;Cells;Child;Data;Development;Disease;Dose;Effectiveness;Generations;Goals;Hospitalization;Human;Immune;Immune response;Immune system;immunogenicity;Immunoglobulin G;improved;Individual;infancy;Infant;infant animal;Influenza;influenza infection;Influenza vaccination;influenza virus strain;influenza virus vaccine;influenzavirus;Interferon Type II;Investigation;Life;Ligands;Lower Respiratory Tract Infection;Maintenance;Marketing;Maternal antibody;Measures;Memory B-Lymphocyte;MF59;Modeling;Mus;nanoparticle;National Institute of Allergy and Infectious Disease;neonate;Newborn Infant;nonhuman primate;OX40;Population;Positioning Attribute;pre-clinical;Predisposition;Research;response;Risk;Role;Signal Transduction;Specificity;stem;Structure of germinal center of lymph node;T cell response;Testing;TLR7 gene;universal influenza vaccine;universal vaccine;Vaccinated;Vaccination;vaccine access;vaccine candidate;Vaccine Design;vaccine development;vaccine response;vaccine safety;vaccine strategy;Vaccines;Virus;Vulnerable Populations;Work

PROJECT_TITLE: Development of vaccine approaches to elicit broadly protective influenza-specific immune responses in infants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-C(02)]