ACTIVITY: ZIH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PROJECT_TERMS: Address;Aging;Algorithms;Alzheimer's Disease;Area;Biological Assay;Biology;Clinical;Cognition;Communication;Data;data archive;data curation;data dictionary;data infrastructure;data ingestion;data management;Data Management Resources;data pipeline;data platform;data quality;Data Science;data sharing;Dedications;Dementia;design;Documentation;Electronic Mail;Electronics;epidemiologic data;experience;Extramural Activities;Feedback;Genetic;Grant;Health Sciences;Human;Human Resources;image archival system;imaging study;Impaired cognition;Improve Access;improved;Individual;Information Systems;Infrastructure;interest;Knowledge;Laboratories;Leadership;Link;Medicine;metabolomics;Methods;Mission;Modernization;Monitor;multidisciplinary;neuroimaging;Occupations;Oral;Persons;Positioning Attribute;Process;Productivity;quality assurance;Quality Control;Reporting;Research;Research Personnel;Research Project Grants;research study;Resources;response;skills;Source;Specimen;System;systems research;Training;Update;web site;Work;Writing

PROJECT_TITLE: ALZHEIMER'S RESEARCH PROJECT: Building the Infrastructure for BLSA Data Management, Documentation, and Sharing


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;HIV/AIDS;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_NAME: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS

PI_NAMEs: TOBIAS, GEOFFREY  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Biological Assay;Biomedical Computing;cancer prevention;Computer software;cost;Data Analytics;data management;Data Reporting;Development;Division of Cancer Epidemiology and Genetics;Documentation;Ensure;Epidemiology;Family;flexibility;Genetic;Laboratories;Malignant Neoplasms;Mission;novel strategies;Population;Population Sciences;Research;Research Activity;Resource Development;Resource Sharing;Resources;response;scientific computing;Support Contracts;System

PROJECT_TITLE: Scientific Computing


ACTIVITY: ZIJ

NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: career development;Communication;Communities;Congresses;design;Development;Division of Cancer Epidemiology and Genetics;editorial;Education;Education and Outreach;Fellowship;Human Resources;Internships;Leadership;lectures;National Cancer Advisory Board;Newsletter;Policies;post-doctoral training;Postdoctoral Fellow;Preparation;Professional counselor;programs;Publishing;Report (document);Reporting;Research;Research Activity;Research Personnel;response;Site Visit;Students;summer student;Training;Training and Education;training opportunity;United States National Institutes of Health

PROJECT_TITLE: Communications, Education and Outreach


NIH_SPENDING_CATS: Cancer;Patient Safety;Prevention

PI_NAMEs: YANG, HANNAH  (contact)

PROJECT_TERMS: Applied Research;Area;authority;Behavior Therapy;Behavioral;cancer epidemiology;clinical center;Ethical Review;Ethics;Genetic study;Health Services Research;human subject;Information Systems;Institutional Review Boards;Iris;Molecular;National Cancer Institute;Persons;Policies;Prevention;Protocols documentation;psychosocial;Research;Research Project Grants;response;Risk Assessment;Scientist;Social Aspects of Cancer;Support Contracts;System;United States National Institutes of Health;Work

PROJECT_TITLE: IRB and NCI Ethical Review Panel (ERP) Support


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: ROCKVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BIOQUAL, INC.

ORG_STATE: MD

PI_NAMEs: LEWIS, MARK  (contact)

PROJECT_TERMS: Advanced Development;AIDS Vaccines;Award;Clinical;Complement;Contracts;Development;DNA;Evaluation Studies;Funding;Grant;HIV;HIV envelope protein;HIV vaccine;immunogenicity;Immunotherapy;Investigator-Initiated Research;Local Microbicides;Modality;Modeling;Mucous Membrane;National Institute of Allergy and Infectious Disease;nonhuman primate;pre-clinical;preclinical evaluation;preclinical study;Prevention;Prevention strategy;programs;Regimen;Research Personnel;Resources;simian human immunodeficiency virus;Vaccination;vaccine candidate;Vaccine Design;vaccine development;vaccine evaluation;Vaccine Research;Vaccines

PROJECT_TITLE: Study to investigate the immunogenicity and efficacy of a rVSV-HIVenv Prime, HIV envelope protein boost vaccination regimen and DNA-HIV Prime, rVSV-HIVenv boost vaccination regimen


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Women's Health Research

ORG_NAME: FISHER BIOSERVICES, INC.

PI_NAMEs: MARTIN, BRITTANY  (contact)

PROJECT_TERMS: 18 year old;Adolescent;Age;Bar Codes;Biological Specimen Banks;Cataloging;Child;Childhood;Clinical;Clinical Research;Cohort Studies;Communicable Diseases;computerized;Contracts;Data;Database Management Systems;Eligibility Determination;Enrollment;Ensure;Equipment;Equipment and supply inventories;experience;Exposure to;Family;Future;Health;HIV;HIV-exposed uninfected infant;HIV/AIDS;Human;Human Resources;improved;Individual;Infant;Monitor;National Institute of Child Health and Human Development;Online Systems;operation;Outcome;pediatric human immunodeficiency virus;Perinatal;perinatal HIV;Pregnancy;pregnant;programs;Protocols documentation;quality assurance;Regulation;repository;reproductive;Reproductive Health;Research;Research Activity;Sampling;Secure;Services;Shipping;Site;Specimen;Support System;System;Toxic effect;Tube;United States;Woman;young woman;Youth

PROJECT_TITLE: NICHD HUMAN BIOSPECIMEN REPOSITORY – MPIDB PHACS HOPE SPECIMEN


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

ORG_STATE: MA

PI_NAMEs: BERRETTA, SABINA  (contact)

PROJECT_TERMS: Advocacy;Alzheimer's Disease;Autopsy;Brain;brain control;brain tissue;Collection;Communities;Contracts;cost;Disease;Goals;Human;human disease;Mental disorders;National Institute of Child Health and Human Development;National Institute of Drug Abuse;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;National Institute on Aging;Nervous System Disorder;Neurodevelopmental Disorder;Patients;Performance;Process;Research;Resources;Site;Tissue Banks;Tissues;United States National Institutes of Health

PROJECT_TITLE: NIH NEUROBIOBANK BRAIN AND TISSUE REPOSITORYCONTRACT TYPE: COST, OPTIONPERIOD OF PERFORMANCE: 09/01/2019 TO 08/31/2020


NIH_SPENDING_CATS: Mental Health;Neurosciences

PHR: This contract is for post-mortem human brain collection sites (i.e. the NIH Brain and Tissue Repositories [NBTR]) for the NIH NeuroBioBank. This contract is part of a strategy by the NIH to maximize availability of post-mortem human biospecimens to the research community while simultaneously achieving greater efficiency and better coordination of brain and tissue repository resources through a centralized approach to brain banking."

PROJECT_TERMS: Autopsy;Brain;Collection;Communities;Contracts;Human;Research;Resources;Site;Tissue Banks;United States National Institutes of Health

PROJECT_TITLE: NIH NATIONAL BRAIN AND TISSUE REPOSITORY


NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: LORTON

ORG_NAME: ARSERVICES, LTD

ORG_STATE: VA

PI_NAMEs: BRYANT, WANDA  (contact)

PROJECT_TERMS: Area;Clinical Research;clinical trial protocol;Clinical Trials;Clinical Trials Database;Data;Elements;Human;Performance;Persons;Protocols documentation;Research Personnel;research study;Services

PROJECT_TITLE: PROTOCOL INFORMATION OFFICE (PIO) SUPPORT SERVICES FOR THE PROCESSING OF CLINICAL TRIAL PROTOCOL DOCUMENTS AND TRACKING THE IMPLEMENTATION AND COMPLETION OF HUMAN CLINICAL RESEARCH STUDIES. PERFORMANC


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Health Services;Mental Health;Natural Products;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: The purpose of the NIMH PDSP is to provide screening of novel synthetic compounds and natural products for potential use as research tools or probes for basic and clinical research, as therapeutic agents for mental disorders, and as positron emission tomography (PET), single photon emission computed tomography (SPECT), and functional magnetic resonance imaging (fMRI) ligands for functional brain imaging.

PI_NAMEs: ROTH, BRYAN  (contact)

PROJECT_TERMS: Award;base;Basic Science;Brain imaging;Clinical Research;Functional Magnetic Resonance Imaging;Imaging ligands;Mental disorders;National Institute of Mental Health;Natural Products;novel;Positron-Emission Tomography;Psychotropic Drugs;Research;screening;screening program;single photon emission computed tomography;Therapeutic Agents;tool

PROJECT_TITLE: TO AWARD THE BASE PERIOD FOR NIMH PSYCHOACTIVE DRUG SCREENING PROGRAM (PDSP). BASE POP: 08/30/2023-08/29/2024.


ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PI_NAMEs: MOISE, JESSICA  (contact)

PROJECT_TERMS: Advocacy;Alzheimer's Disease;Autopsy;Brain;brain control;brain tissue;Collection;Communities;Contracts;Disease;Goals;Human;human disease;Mental disorders;National Institute of Child Health and Human Development;National Institute of Drug Abuse;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;National Institute on Aging;Nervous System Disorder;Neurodevelopmental Disorder;Patients;preservation;Process;Research;Resources;Services;Site;Tissue Banks;Tissues;United States National Institutes of Health

PROJECT_TITLE: THE NIH NEUROBIOBANK BRAIN AND TISSUE REPOSITORY (NBTR) TO PROVIDE SERVICES THAT WILL ACTIVELY ACQUIRE, RECEIVE, STORE, CURATE, PRESERVE, AND DISTRIBU


ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PI_NAMEs: BOGGS, ABBEY  (contact)

PROJECT_TERMS: cohort;Data;design;Methodology;National Cancer Institute;SEER Program

PROJECT_TITLE: SPECIALIZED ANALYTIC DATA SUPPORT for SEER-MHOS DATA EXPANSIONS


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: NATICK

ORG_NAME: PACDNA LLC

PHR: Project Narrative Mutated KRAS is a highly prevalent oncoprotein driving a number of cancers, but pharmacological inhibition is  limited to only the G12C mutant despite over thirty years of research. Here, we propose to develop an  antisense oligonucleotide-based therapeutic agent which takes advantage of our proprietary delivery  technology. Building upon strong efficacy indication in non-small cell carcinoma mouse models, we will perform  additional structure optimizations, conduct toxicology/pharmacology studies in both mice and non-human  primates, and obtain additional indications in advanced preclinical animal models.

PI_NAMEs: ZHANG, KE  (contact)

PROGRAM_OFFICER_NAME: FRANCA-KOH, JONATHAN C

PROJECT_TERMS: Acceleration;acute toxicity;Address;alternative treatment;Animal Model;Anti-Inflammatory Agents;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Area Under Curve;Automobile Driving;Binding;Biological Availability;Biological Products;Blood;Blood Coagulation Disorders;Body Weight;cancer cell;Cells;Characteristics;Chemicals;Clinic;Clinical;Clinical Chemistry;clinical development;Coagulation Process;Complement;cytokine;Data;Deoxyribonucleases;Development;dosage;Drug Kinetics;Exhibits;Gene Expression Regulation;Genes;Goals;Half-Life;Human;Immune system;Immunity;Immunocompetent;Immunologic Stimulation;immunotoxicity;improved;In Vitro;in vivo;Inflammation;inhibitor;Injections;intravenous administration;Kidney;knock-down;KRAS2 gene;Libraries;Liver;Lung;Macaca fascicularis;Malignant Epithelial Cell;Malignant Neoplasms;Marketing;Measurement;Mediating;MEKs;Messenger RNA;Methods;Modality;Modeling;Modification;Molecular;Monitor;Monkeys;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutate;Mutation;nanoparticle;neglect;Non-Small-Cell Lung Carcinoma;nonhuman primate;novel;nucleic acid-based therapeutics;Nucleic Acids;Oligonucleotides;Oncogenes;Oncoproteins;patient derived xenograft model;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Pharmacology and Toxicology;Pharmacology Study;Phase;phosphodiester;Plasma;Polyethylene Glycols;Polymers;pre-clinical;Pre-Clinical Model;preclinical toxicity;Property;Proteins;Publishing;Refractory;Research;response;Ribonuclease H;Safety;safety assessment;Side;side effect;Signal Pathway;single molecule;Single-Stranded DNA;small molecule;small molecule inhibitor;stem;Structure;subcutaneous;Technology;Therapeutic;Therapeutic Agents;Therapeutic Intervention;Toll-like receptors;Toxic effect;Translating;Translational Repression;Translations;treatment strategy;tumor;Tumor Suppression;uptake;Urine;Vertebral column;Xenograft Model

PROJECT_TITLE: Molecular brush-conjugated antisense oligonucleotide as a pan-KRAS depletion agent

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-S(12)B]


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: ITHACA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative  In the present project we propose to address critical gaps in our understanding of the risk posed by Highly pathogenic avian influenza (HPAI) circulation in dairy cattle and its shedding in milk from affected animals. Our team will investigate the efficacy of raw milk cheese aging- and will determine the kinetics of virus inactivation in several dairy products. Additionally, we will identify products that can inactivate the virus in raw milk, so that these products can be used to mitigate the risks posed by raw milk to other animals and to humans. .

PI_NAMEs: ALCAINE, SAMUEL DAVID;DIEL, DIEGO G (contact);MARTIN, NICOLE

PROGRAM_OFFICER_NAME: BUTLER, KRISTIN

PROJECT_TITLE: Mitigation of Highly pathogenic influenza (HPAI) in milk and dairy products

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CFSN-T (05)]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: UNIVERSITY OF MASSACHUSETTS BOSTON

PI_NAMEs: ESCALERA, LIYA  (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Address;American;Area;behavioral and social science;Behavioral Sciences;Black Populations;Boston;Cancer Center;cancer health disparity;career;career development;Color;Communication;Communities;COVID-19 pandemic;Dana-Farber Cancer Institute;design;Development;Disabled Persons;Discipline;Discipline of Nursing;Disparity;Doctor of Philosophy;Education;education research;Educational Status;Enrollment;Ethnic Population;evidence base;experience;Faculty;Fellowship;Fostering;Genomics;Graduate Degree;graduate school;graduate student;Grant;Group Affiliation;Growth;Health;health communication;Health Disparities Research;health disparity;Healthcare;improved;Individual;Infrastructure;innovation;Institutional Racism;interest;Intervention;Investments;Knowledge;Latinx;Low Income Population;Malignant Neoplasms;Manuscripts;Massachusetts;Mentors;Methods;multidisciplinary;Native Americans;NCI Center for Cancer Research;outreach;Peer Review;personalized cancer therapy;Phase;physical science;Population;Population Heterogeneity;Postbaccalaureate;Postdoctoral Fellow;Preparation;Process;Productivity;programs;Publications;racial population;Research;research and development;Research Design;Research Personnel;Research Project Grants;research study;Science;Science Enrichment;Scientific Advances and Accomplishments;Scientist;skills;Students;success;Training;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Work

PROJECT_TITLE: Research Education Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Mental Health;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: THE EMMES COMPANY, LLC

PI_NAMEs: SHERMAN, SETH  (contact)

PROJECT_TERMS: 18 year old;Address;Affect;Age Months;Beginning of Life;Behavior;Biological;Birth;Characteristics;Child Development;Child Rearing;Childhood;childhood adversity;Clinical;clinical research site;cohort;Collection;COVID-19 pandemic;Data;Data Collection;Data Coordinating Center;data platform;Data Set;Development;Discrimination;Disease;Disparity;economic disparity;Eligibility Determination;Enrollment;Environment;ethnic diversity;Ethnic Origin;Etiology;Family;Fathers;fetal;First Pregnancy Trimester;follow up assessment;follow-up;Generations;Gestational Age;Health;health disparity;improved;Individual;Inequality;Infant;Infant Development;Infant Health;Intervention Studies;Interview;Interviewer;Knowledge;knowledge base;Life;Life Cycle Stages;Link;Literature;Maternal Health;Measurement;Measures;Mediating;Medical Records;Mental Health;Methods;Monitor;Names;Neighborhoods;Neonatal;neurodevelopment;observational cohort study;offspring;Outcome;outcome disparities;pandemic disease;Parents;Participant;participant retention;Patient Self-Report;perceived stress;Performance;Persons;Phenotype;physical conditioning;Play;Population;population health;postnatal;Poverty;Pregnancy;Pregnant Women;prenatal;prospective;protective factors;Psychiatric Diagnosis;Psychopathology;Race;racial disparity;racial diversity;recruit;Research;Research Design;research study;Risk Factors;Role;Sampling;social disparities;Social support;Socioeconomic Status;socioeconomics;Source;Spanish;Strategic Planning;Stressful Event;substance use;System;Testing;theories;Training;Translations;transmission process;Umbilical Cord Blood;United States;United States National Institutes of Health;Update;Woman

PROJECT_TITLE: DATA COORDINATING CENTER FOR THE PRENATAL AND CHILDHOOD MECHANISMS OF HEALTH DISPARITIES:  RECRUITMENT AND FOLLOW-UP OF SECOND SUBCOHORT OF PREGNANT WOMEN AND THEIR PARTNERS


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Pediatric;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: SALT LAKE CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Diarrheal diseases are a leading cause of morbidity and mortality in children worldwide. Appropriate management of childhood diarrhea depends on the type of pathogen responsible, but in many cases testing is not affordable or feasible. We propose to develop and validate a tool for rural healthcare workers that predicts etiology for pediatric diarrhea, and supports clinical decision making.

PI_NAMEs: KHAN, ASHRAFUL ISLAM;LEUNG, DANIEL TED (contact);NELSON, ERIC JORGE

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: 5 year old;acceptability and feasibility;Accounting;Acute Diarrhea;Age;Antibiotics;antimicrobial;Antimicrobial Resistance;Bangladesh;Blood;Breast Feeding;care costs;Caregivers;Cause of Death;Cellular Phone;Cessation of life;Child;Childhood;Climate;Clinical;clinical application;clinical decision support;clinical decision-making;Clinical Management;clinical predictive model;Collaborations;cost;Cross-Over Trials;Data;Development;Diagnosis;Diagnostic;Diarrhea;diarrheal disease;Drug Prescriptions;Electronics;Etiology;evidence base;Feasibility Studies;feasibility trial;Feces;Fever;Fostering;Goals;Habits;Health;Health Personnel;health training;Healthcare;Hydration status;implementation strategy;improved;Individual;innovation;Knowledge;Laboratories;Location;low and middle-income countries;Maps;Measures;Medical;Methods;mHealth;Mobile Health Application;Modeling;Modification;Morbidity - disease rate;mortality;pathogen;Patient Care;Patients;Performance;Phase;Physicians;Population;predictive tools;Prevalence;Primary Care;Provider;Randomized;Randomized, Controlled Trials;research and development;respiratory;Rural;rural area;rural healthcare;rural setting;Seasons;Site;support tools;Syndrome;Testing;tool;Toxic effect;Training;Trust;Viral;Vomiting;Work

PROJECT_TITLE: A mobile health tool to improve antibiotic stewardship among village doctors in Bangladesh

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Contraception/Reproduction;Prevention

ORG_CITY: PHOENIX

ORG_STATE: AZ

PROJECT_TERMS: Applications Grants;Biological;Contraceptive Agents;Contraceptive methods;Contractor;Contracts;Critiques;experience;Funding;Goals;Grant;Intellectual Property;Laws;Legal patent;men;Methods;Mission;National Institute of Child Health and Human Development;Pharmacologic Substance;prevent;programs;Research;Research Activity;research and development;Services;small molecule;Staff Development;unintended pregnancy;Woman

PROJECT_TITLE: INTELLECTUAL PROPERTY CONSULTING SERVICE for Contraception Research


ORG_CITY: VIENNA

PI_NAMEs: GAMERMAN, GARY  (contact)

PROJECT_TERMS: Anti-Infective Agents;Antibodies;Authorization documentation;Award;Biological;Biological Products;Biological Sciences;Characteristics;Contraceptive Agents;Contraceptive methods;Contracts;design;Development;Devices;experience;Female;Funding;Gel;Goals;Government;Grant;Human;insight;Investigational New Drug Application;Knowledge;Logistics;male;manufacture;men;National Institute of Child Health and Human Development;novel therapeutics;Pharmaceutical Preparations;Pharmacologic Substance;Polymers;pre-clinical;Preclinical Testing;Prevention;Process;programs;Property;Published Comment;Recommendation;Regulatory Pathway;Reproductive Health;Research;research and development;Services;small molecule;Technology;Testing;Woman

PROJECT_TITLE: AD HOC CONSULTING AND OPINIONS FOR REGULATORY RELATED SERVICES FOR CONTRACEPTIVE RESEARCH


ORG_CITY: DURHAM

ORG_NAME: LEADING EDGE PHARMTOX, LLC

PI_NAMEs: KELCE, WILLIAM  (contact)

PROJECT_TERMS: Award;clinical development;Consultations;Contraceptive Agents;Contraceptive methods;Contracts;Data;design;Development Plans;drug development;drug discovery;Ensure;experience;Experimental Designs;Funding;Grant;Knowledge;men;Monitor;National Institute of Child Health and Human Development;participant safety;Pharmacology and Toxicology;Procedures;Program Development;Protocols documentation;Recommendation;Reporting;reproductive;Reproductive Sciences;Research;research facility;Research Personnel;Risk Assessment;Safety;Services;Technology;Toxicology;U-Series Cooperative Agreements;Woman

PROJECT_TITLE: TOXICOLOGY CONSULTING FOR REPRODUCTIVE SCIENCE and Contraception Research


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Prevention;Women's Health Research

ORG_CITY: SAN DIEGO

ORG_NAME: POLYPEPTIDE LABORATORIES SAN DIEGO

ORG_STATE: CA

PI_NAMEs: SCANO, BERNADETTE  (contact)

PROJECT_TERMS: Address;Adolescent;Child Development;Clinical;Clinical Research;Clinical Trials;Collaborations;Contraceptive Agents;Contraceptive methods;Contractor;Contracts;cost;Development;Ethics;Failure;Government;Growth and Development function;Health;Infant;innovation;Investigational Drugs;KISS1 gene;Laboratories;life span;men;Mentors;Methods;Mission;National Institute of Child Health and Human Development;novel;Peptide Synthesis;Peptides;Personal Satisfaction;Pharmaceutical Preparations;Population;population health;Pregnant Women;Program Development;Protocols documentation;Reproduction;Research;research and development;research clinical testing;Research Personnel;Services;Shipping;stability testing;Translating;Translational Research;Vendor;Vial device;Woman

PROJECT_TITLE: STORAGE AND STABILITY STUDY OF DRUG SUBSTANCES AND PRODUCTS FOR CONTRACEPTIVE DEVELOPMENT


ORG_NAME: GARDNER PHARMACOLOGY LLC

PI_NAMEs: GARDNER, ERIN  (contact)

PROJECT_TERMS: clinical development;Clinical Trials;Collaborations;Computer software;Consultations;Contraceptive Agents;Contraceptive methods;Contractor;Contracts;Data;Data Analyses;data modeling;design;Development Plans;Dose;drug development;drug discovery;Drug Kinetics;Ensure;Essential Drugs;Experimental Designs;experimental study;Feedback;Frequencies;Funding;Goals;Grant;improved;men;Methodology;Mission;Monitor;National Institute of Child Health and Human Development;Outcome;participant safety;Pharmaceutical Preparations;pharmacologic;Pharmacology;Plasma;pre-clinical;prevent;Procedures;programs;Protocols documentation;Recommendation;Reporting;Research;research and development;research facility;Research Personnel;Risk Assessment;Route;Safety;Sampling;Services;Staff Development;Time;Toxicology;U-Series Cooperative Agreements;unintended pregnancy;Woman

PROJECT_TITLE: PHARMACOLOGY CONSULTING SERVICES for Contraception Research


PROJECT_TERMS: Address;Adolescent;Child Development;Clinical;Clinical Research;Clinical Trials;Collaborations;Contraceptive Agents;Contraceptive methods;Contractor;Contracts;cost;Development;Ethics;Failure;Government;Growth and Development function;Health;Infant;innovation;Investigational Drugs;KISS1 gene;Laboratories;life span;men;Mentors;Methods;Mission;National Institute of Child Health and Human Development;novel;Peptide Synthesis;Personal Satisfaction;Pharmaceutical Preparations;Population;population health;Pregnant Women;Program Development;Protocols documentation;Reproduction;Research;research and development;research clinical testing;Research Personnel;Shipping;stability testing;Translating;Translational Research;Vendor;Vial device;Woman

PROJECT_TITLE: STORAGE AND STABILITY TEST ON GMP GRADE ACYLINE AND OTHER DRUG SUBSTANCES FOR CONTRACEPTIVE DEVELOPMENT


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Opioid Misuse and Addiction;Opioids;Patient Safety;Prevention;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PI_NAMEs: MARSCH, LISA A. (contact)

PROGRAM_OFFICER_NAME: DOBBINS, RONALD

PROJECT_TERMS: Alcohols;Artificial Intelligence;Behavior Therapy;behavioral health;Bioinformatics;Cannabis;Caring;chronic pain;Clinical Treatment;Clinical Trials;Clinical Trials Network;Communication;Communities;Community Healthcare;Community Networks;community organizations;comorbidity;Complement;Data Analytics;data privacy;Data Science;design;digital data;digital health;digital technology;digital treatment;disorder prevention;Drug abuse;experience;Experimental Designs;Funding;Health Services Accessibility;Healthcare;Helping to End Addiction Long-term;implementation science;improved;Individual;Infrastructure;innovation;Lead;Maine;marijuana use;Medical;Mental disorders;National Clinical Trials Network;National Institute of Drug Abuse;New Hampshire;Opiate Addiction;Opioid;opioid misuse;opioid use;opioid use disorder;Pharmaceutical Preparations;Pharmacy facility;Policies;predictive modeling;Pregnant Women;Productivity;Protocols documentation;Public Health;randomized trial;Research;Research Personnel;Resources;Rural;Rural Community;scale up;Science;Security;social media;Speed;Stimulant;substance use;Substance Use Disorder;substance use treatment;System;Technology;Time;Tobacco;treatment disparity;Treatment Effectiveness;United States National Institutes of Health;Vermont;Youth


FUNDING_MECHANISM: SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: LUNA LABS USA, LLC

PI_NAMEs: WRIGHT, MELISSA  (contact)

PROJECT_TERMS: Acceleration;acquired factor;Age;Aggressive course;Anti-viral Agents;antiretroviral therapy;burden of illness;Complex;Contracts;Death Rate;Development;drug action;Goals;Hepatitis C Acquisition;Hepatitis C Therapy;Hepatitis C virus;HIV;HIV Seronegativity;HIV/HCV;Hydrogels;Implant;Individual;Liver diseases;Liver Fibrosis;Morbidity - disease rate;mortality;Persons;Pharmaceutical Preparations;Polymers;Primary carcinoma of the liver cells;Risk Factors;Subcutaneous Injections;tumor;United States;Viral;Viral hepatitis

PROJECT_TITLE: Long-Acting Antiviral Implant for the Treatment of HCV


NIH_SPENDING_CATS: HIV/AIDS;Pediatric;Pediatric - AIDS

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PROJECT_TITLE: Expertise in the Product Development Lifecycle


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: Project Narrative Cardiovascular and kidney disease frequently co-exist for reasons that are poorly understood. Soluble urokinase plasminogen active receptor (suPAR) is a recently discovered cause of kidney disease and a strong marker of cardiovascular risk, and we propose studying the role for suPAR in cardiovascular disease and testing the hypothesis that people with high suPAR levels have early and progressive atherosclerosis, independently of its known impact on the kidneys. Understanding the role of suPAR as a novel pathogenic factor of CVD and biomarker of risk will lead to the design and study of therapeutic and preventive interventions with wide reaching impact.

PI_NAMEs: HAYEK, SALIM  (contact)

PROGRAM_OFFICER_NAME: PUGGAL, MONA A

PROJECT_TERMS: Acceleration;Address;Arterial Fatty Streak;arterial stiffness;Atherosclerosis;Binding;biobank;Biological Markers;Bone Marrow;Brain natriuretic peptide;C-reactive protein;Calcium;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cause of Death;Chronic;Chronic Kidney Failure;Circulation;clinical practice;cohort;coronary artery calcium;coronary calcium scoring;cytokine;Data;data repository;Data Set;design;Development;Diffuse;Discrimination;Disease;Disease Outcome;disorder risk;Endothelium;Enrollment;Environmental Exposure;Epidemiology;Etiology;experience;Experimental Models;experimental study;follow-up;Foundations;Functional disorder;Funding;Genes;Genetic;Genetic Determinism;genetic variant;genome wide association study;Glycoproteins;Goals;healthy volunteer;high risk;individualized medicine;Inflammation;Inflammatory;Injections;Injury;Injury to Kidney;Innate Immune System;insight;Kidney;Kidney Diseases;kidney dysfunction;Knowledge;Link;Measurement;Measures;Membrane;Mendelian randomization;Meta-Analysis;modifiable risk;Multi-Ethnic Study of Atherosclerosis;multidisciplinary;Myeloid Cells;novel;Outcome;overexpression;Participant;Pathogenicity;Pathway interactions;Patients;Persons;pharmacologic;Placebos;Plasminogen;PLAU gene;PLAUR gene;Population;prevent;preventive intervention;Process;Prospective cohort;Prospective Studies;Randomized;randomized trial;receptor;Recombinant Proteins;Renal function;Research;response;Risk;Risk Factors;Role;rosuvastatin;Sampling;Science;Secure;Signaling Molecule;Surface;Testing;Therapeutic Intervention;Therapeutic Studies;therapeutic target;Troponin I;Tubular formation;United States;United States National Institutes of Health;Urokinase;Urokinase Plasminogen Activator Receptor;Virulence Factors;volunteer;Work

PROJECT_TITLE: Role of SuPAR in the Intersection between Cardiovascular and Kidney Disease

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ORG_CITY: MORGANTOWN

ORG_DEPT: PEDIATRICS

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Project Narrative We seek to understand why some children with single ventricle heart disease fail after surgical procedures. Currently, images from echocardiography, catheterizations, and cardiovascular magnetic resonance are being used to qualitatively choose the best surgical approach for these patients. In this project, we aim to quantitatively determine the most optimal surgical repair for each patient by simulating different surgical repairs and comparing the post-surgical hemodynamics.

PI_NAMEs: HEDJAZI MOGHARI, MEHDI  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;Algorithms;Anastomosis - action;Anatomy;Anesthesia procedures;Applications Grants;automated segmentation;Blood;Blood flow;blood flow measurement;Blood Pressure;Breathing;Cardiac;Cardiac Surgery procedures;Cardiovascular system;Catheterization;Cessation of life;Child;Circulation;Compensation;Complex;Congenital Abnormality;congenital heart abnormality;convolutional neural network;Data;Data Set;Decision Making;design;Echocardiography;Elasticity;Elements;expiration;Friction;Heart;heart function;heart imaging;heart motion;hemodynamics;Image;image registration;imaging modality;improved;Lead;Life;Liquid substance;Lung;Magnetic Resonance;Magnetic Resonance Imaging;mathematical methods;Measures;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;Motion;Myocardium;Newborn Infant;Operative Surgical Procedures;Outcome;Palliative Surgery;Patient Outcomes Assessments;Patients;Phase;Positioning Attribute;Property;Radial;Rationalization;reconstruction;repaired;Research;respiratory;segmentation algorithm;simulation;Single ventricle congenital heart disease;spatial relationship;Surface;Surgeon;Surgical Models;Survival Rate;System;three-dimensional modeling;Time;two-dimensional;United States;vector;Venous system;virtual surgery;viscoelasticity

PROJECT_TITLE: Simulating Cardiac Surgery for Children with Severe Congenital Heart Disease

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: There is a fundamental gap in understanding the early origins of Chronic Obstructive Pulmonary Disease. Our long term goal is to arrest COPD progression by under- standing its earliest stages. We will recruit a new cohort of younger at-risk individuals to link chest imaging and pathologic abnormality with longitudinal disease progression and thus define potentially targetable mechanisms laying the foundation for developing disease-modifying therapies.

PI_NAMEs: CURTIS, JEFFREY LOUIS;HAN, MEILAN K;MARTINEZ, FERNANDO J (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Activities of Daily Living;Age;Age Years;aged;airway epithelium;airway obstruction;airway remodeling;airway surface liquid;Anatomy;Biological;Biological Markers;Biological Process;Bronchoalveolar Lavage;Bronchodilator Agents;Bronchoscopy;Cell Physiology;cell type;chest computed tomography;Chest imaging;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Data;cohort;Cross-Sectional Studies;Data;Data Collection;Dendritic Cells;detector;Development;Diagnosis;Disease;Disease Progression;Distal;early detection biomarkers;Early identification;Enrollment;Epithelium;Exhalation;follow-up;former smoker;Foundations;Funding;genetic signature;Goals;Growth;Histologic;Host Defense;Human;IL17 gene;Image;imaging approach;Immune;Immune response;immunoreaction;Individual;Industry;Infrastructure;innovation;insight;Knowledge;Lead;Leukocytes;Life;Link;Lung;Maps;Measures;Mucins;National Heart, Lung, and Blood Institute;never smoker;novel;Pathologic;Pathology;Phase;Physical condensation;Positioning Attribute;Predisposition;primary outcome;Process;programs;Pulmonary Emphysema;pulmonary function decline;Pulmonary Function Test/Forced Expiratory Volume 1;radiological imaging;recruit;Research;Resolution;Respiratory Signs and Symptoms;response;Risk;secondary analysis;Site;small airways disease;Smoker;Smoking;Smoking History;Spirometry;Sputum;Symptoms;Testing;therapeutic target;Tissues;Visit;X-Ray Computed Tomography

PROJECT_TITLE: Understanding the Origins of Early COPD

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ACTIVITY: ZIA

ADMINISTERING_IC: CL

IC_NAME: CLINICAL CENTER

ORG_NAME: CLINICAL CENTER

PI_NAMEs: WALLEN, GWENYTH R (contact)

PROJECT_TERMS: 18 year old;acceptability and feasibility;actigraphy;Admission activity;Adult;alcohol abuse therapy;Alcohol dependence;alcohol rehabilitation;alcohol use disorder;Alcohols;behavioral sleep intervention;Chronic Insomnia;Clinic;clinical center;Cognitive Therapy;comparative efficacy;Control Groups;cost;Data Collection;data quality;diaries;drinking;Drug Metabolic Detoxication;Education;Effectiveness;Effectiveness of Interventions;Electronics;experience;Goals;group intervention;improved;improved outcome;Individual;Inpatients;Internet;Intervention;Manuscripts;Methods;National Institute on Alcohol Abuse and Alcoholism;Nonpharmacologic Therapy;Online Systems;Outcome;Outcome Measure;Outpatients;Participant;participant enrollment;Persons;Phase;Phase I Clinical Trials;Play;Population;Preparation;Prevalence;primary outcome;Process;Program Effectiveness;programs;Protocols documentation;Randomized;Randomized, Controlled Trials;Recommendation;Recovery;Rehabilitation therapy;Research;response;Rest;screening;secondary outcome;Severities;Sleep;Sleep Disorders;Sleeplessness;sound;Testing;Time;Training;United States National Institutes of Health

PROJECT_TITLE: Pilot RCT of web-based behavioral sleep intervention for individuals with alcohol use disorder


PI_NAMEs: LEE, LENA  (contact)

PROJECT_TERMS: 18 year old;Address;Aging;Allogenic;American;Anxiety;arm;Behavior Therapy;care giving burden;Caregivers;caregiving;Caring;clinical center;Control Groups;Data Analyses;Data Collection;design;Development;Disease;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness study;Eligibility Determination;Enrollment;experience;Family member;Friends;group intervention;Head;Health;Hematopoietic Stem Cell Transplantation;Home;improved;Individual;Intervention;Intervention Studies;Malignant Neoplasms;Meditation;Mental Depression;mindfulness;Nature;open data;Outcome;Pain;Patients;perceived stress;Personal Satisfaction;Population;primary caregiver;prospective;Protocols documentation;Questionnaires;Randomized;recruit;Research;Sampling;skills;Sleep disturbances;Stem cell transplant;Stress;Stress and Coping;stress reduction;Study Subject;Symptoms;Techniques;Testing;Time;Translations;Transplant Recipients;Transplantation Conditioning;treatment arm;United States National Institutes of Health;Yoga

PROJECT_TITLE: Effectiveness of a Stress Reduction Intervention in Caregivers of Allogeneic Hematopoietic Stem Cell Transplant (HSCT) Recipients


PROJECT_TERMS: 18 year old;Abstinence;addiction;Admission activity;Adrenal Cortex Hormones;Adult;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol use disorder;Alcohols;analysis pipeline;Antibiotics;Biological;Characteristics;Clinic;clinical center;comorbidity;Compensation;Complex;Consent;Data;Decision Making;Dental Hygiene;Diet;Diet Records;Dietary History;Disease;drinking;Drug Metabolic Detoxication;Enrollment;Evaluation;Exclusion Criteria;Feces;Gastrointestinal Diseases;Guidelines;gut microbiome;gut-brain axis;healthy volunteer;Human;Human Microbiome;Immunosuppressive Agents;Impairment;Individual;Inflammation Mediators;Informed Consent;Inpatients;interest;Intervention;Liver diseases;Manuscripts;Measures;Mental disorders;Metabolic;microbial;microbiome;microbiome research;next generation sequencing;Oral;oral microbiome;Participant;Patients;Policies;Population;Preparation;Probiotics;Protocols documentation;psychosocial;Publishing;Research;Ribosomal RNA;Sampling;Scientist;screening;Severities;Shotgun Sequencing;Specimen;theories;Tongue;Treatment Protocols;United States National Institutes of Health

PROJECT_TITLE: Longitudinal Changes in the Oral and Gut Microbiome of Individuals with Alcohol Dependence


PROJECT_TERMS: Abstinence;Accelerometer;Alcohol consumption;Alcohol dependence;alcohol misuse;alcohol rehabilitation;alcohol use disorder;Alcoholism;alcoholism therapy;Back;Behavior;Behavioral;Belief;Cessation of life;Clinical Research;Communities;Complex;craving;Data;Data Analyses;Development;drinking;Expectancy;experience;Home;Individual;Inpatients;Interview;Investigation;Literature;Maintenance;Manuscripts;Measures;Methods;Modeling;National Institute on Alcohol Abuse and Alcoholism;open data;Outcome;Outpatients;Participant;Patients;Perception;Personal Satisfaction;Physical Dependence;Problem behavior;Process;Public Health;Qualitative Methods;Recovery;Rehabilitation therapy;Relapse;relapse prediction;Research;research facility;Schedule;Self Efficacy;Sleep;Sleep disturbances;sleep pattern;sleep quality;social cognitive theory;Structure

PROJECT_TITLE: Sleep Disturbance and Relapse in Individuals with Alcohol Dependence: An Exploratory Mixed Methods Study


PI_NAMEs: DE GIORGI, VALERIA  (contact)

PROJECT_TERMS: Acute Hepatitis C;acute infection;Aging;Antibodies;Antibody Response;Autobiography;autocrine;CCL2 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell mediated immune response;chemokine;CHI3L1 gene;Chitinase;Chronic;Chronic Disease;Chronic Hepatitis C;chronic infection;chronic liver disease;circulating microRNA;Cirrhosis;cohort;Collaborations;Collagen;Containment;curative treatments;cytokine;cytotoxic;Disease Outcome;Disease Progression;Dreams;Escape Mutant;Evolution;extracellular vesicles;Fibrosis;Genotype;Goals;Helper-Inducer T-Lymphocyte;Hepatic;Hepatic Stellate Cell;Hepatitis;Hepatitis C;Hepatitis C virus;Heterogeneity;Immune;Immune Evasion;Immune response;Immune system;Immunologic Factors;Immunologics;Impairment;Indolent;Infection;Interferons;lectures;Liver;Liver Fibrosis;liver stiffness;Measurement;Measures;MicroRNAs;Mutation;National Institute of Allergy and Infectious Disease;National Institute of Diabetes and Digestive and Kidney Diseases;neutralizing antibody;next generation sequencing;Nobel Prize;Outcome;outcome prediction;Patients;Plasma;Population;predictive marker;pressure;Process;Publishing;Recovery;Research;response;Science;Serum;Specimen;stellate cell;Testing;Therapeutic;Time;Transforming Growth Factor beta;Variant;Viral;Viral Antigens;Viral Load result;Virus

PROJECT_TITLE: Viral And Immune Factors That Influence Recovery Or Progression Of Hepatitis C


PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Adult;Alloimmunization;American;Antibodies;antibody detection;Appearance;Area;Biological Assay;Blood;Blood Banks;Blood donor;Blood donor screening;blood product;Blood Tests;Blood Transfusion;California;Caribbean region;Chikungunya virus;Child;Childhood;chronic liver disease;Clinical;Cohort Studies;Collaborations;COVID-19 pandemic;Cytomegalovirus;Cytomegalovirus Infections;Data;Dengue;Detection;detection assay;Developed Countries;Development;DNA;Enrollment;Epidemic;Epitopes;Female;follow-up;Gene Chips;Hepatitis;Hepatitis B Transmission;Hepatitis B Virus;Hepatitis C Transmission;Hepatitis C virus;Hepatitis E virus;High Prevalence;high risk behavior;HIV;HIV/HCV;HLA Antigens;Hospitals;Human Herpesvirus 4;Human Herpesvirus 8;Human Parvovirus B19;Immunoglobulin G;Immunoglobulin M;improved;Infection;Infectious Agent;Investigation;Journals;Leukocytes;Light;Link;Lymphocyte;Measures;Medical center;meetings;Methods;Microchimerism;Molecular;Monitor;multiplex assay;Nucleic Acids;Operative Surgical Procedures;Outcome;Parvovirus;pathogen;patient safety;Patients;Phylogenetic Analysis;Population;Prevalence;Process;prospective;Prospective Studies;Prospective, cohort study;Publishing;real time monitoring;Reporting;repository;Reproducibility;Research Institute;Risk;Safety;Sampling;San Francisco;screening;seroconversion;Serology;Seroprevalences;South America;Specimen;suburb;systems research;Techniques;Technology;Testing;Time;Transfusion;Transfusion-Transmitted Virus;transmission process;Trauma;Travel;United States National Institutes of Health;Vascular blood supply;vigilance;Viral;viral detection;Viral Genome;viral RNA;viral transmission;Virus;Virus Diseases;Y Chromosome;Zika Virus

PROJECT_TITLE: Transfusion-related Infections Prospectively Studied (TRIPS)


PROJECT_TERMS: anergy;Antibodies;Antigen-Antibody Complex;Autoimmune Diseases;Autoimmunity;B Cell Proliferation;B-Cell Development;B-Cell NonHodgkins Lymphoma;B-Lymphocyte Subsets;B-Lymphocytes;Binding;Biogenesis;cancer cell;CD19 gene;CD81 gene;Cell Communication;Cell surface;Cells;Chromosomal Duplication;Chromosome Deletion;Chronic;Chronic Hepatitis C;chronic infection;Clinical;Clonal Expansion;co-infection;Collecting Cell;Complement;Complement 3d Receptors;Complement Activation;complement system;Complex;Data;Detection;Development;Disease;Epidemiology;Epigenetic Process;Erythrocytes;Event;Extrahepatic;Fluorescent in Situ Hybridization;Gene Expression;Gene Fusion;gene translocation;Genetic;genetic signature;global health;Grant;Hepatic;Hepatitis B Virus;Hepatitis C;Hepatitis C Therapy;Hepatitis C virus;Hepatology;Host Defense;Immunoglobulin Genes;Immunosuppression;Infection;Innate Immune Response;insight;Interferon Type I;Intervention;Investigation;Link;Liver diseases;Lymphoid Tissue;Lymphoma;Lymphomagenesis;Lymphoproliferative Disorders;Manuscripts;Mediating;Messenger RNA;Molecular;Mongolia;monocyte;MS4A1 gene;Mutation;National Institute of Allergy and Infectious Disease;Natural Immunity;non-Hodgkin's lymphoma patients;Oncogenic;overexpression;Paraffin Embedding;Pathogenesis;Pathway interactions;Patients;Pattern;Peripheral;Peripheral Blood Mononuclear Cell;Plasma;programs;Proliferating;protein expression;Regulation;Regulator Genes;response;Ribosomes;Risk;RNA;RNA Probes;Role;Sampling;Signal Transduction;Small Nucleolar RNA;transcriptome sequencing;Viral;Viral Proteins;Virus;Virus Diseases;Virus Replication;Visualization;Whole Blood

PROJECT_TITLE: HCV Infection and Innate Immunity


PI_NAMEs: SOLOMON, MICHAEL  (contact)

PROJECT_TERMS: Admission activity;Adult;Aging;Arrhythmia;Blood;Body System;Boston;Cardiac;cardiac intensive care unit;Cardiogenic Shock;Cardiology;Cardiovascular Diseases;Caring;Clinical;clinical care;clinical center;Collection;comorbidity;Complex;Coronary Care Units;Critical Care;Critical Illness;Data;Data Collection;Data Coordinating Center;data de-identification;Decision Making;Detection;Diagnostic;Disease;Eligibility Determination;Environment;Evaluation;Functional disorder;Health;Heart;Heart failure;Heart Transplantation;hemodynamics;Hospitals;immunosuppressed;Institutional Review Boards;Intensive Care;Intensive Care Units;Intervention;Ischemia;Laboratories;Length of Stay;Life;Lung;Managed Care;Medical;Medical Records;medical schools;Modernization;Multicenter Studies;multidisciplinary;Myocardial Infarction;Observational Study;Participant;participant enrollment;Patient Care;patient population;Patient-Focused Outcomes;Patients;Privacy;Procedures;Process;prognostication;Protocols documentation;Records;Refractory;Registries;Reporting;Resources;Risk;secondary outcome;Selection for Treatments;Septic Shock;Site;Specimen;Therapeutic;Transplant Recipients;Triage;United States National Institutes of Health;Woman

PROJECT_TITLE: An Observational Study of Cardiac Critical Care Management in Multidisciplinary and Cardiac Intensive Care Units


PROJECT_TERMS: Adult;American;American Heart Association;Antiphospholipid Antibodies;Arteriosclerosis;Ascorbic Acid;assay development;B-Lymphocytes;Basic Science;Bioenergetics;Biological Assay;Biology;Blood;Blood specimen;Blood Vessels;Cardiology;cell free DNA;Cell Line;Cell Physiology;Cell Separation;Cells;clinical center;Clinical Research;Coagulation Process;Collaborations;Collection;college;Communicable Diseases;convalescent plasma;COVID-19;COVID-19 patient;Critical Care;density;Development;DNA;Ebola virus;endothelial dysfunction;Enrollment;Enzymes;Evaluation;extracellular;Fibrinolysis;Flow Cytometry;Generations;Genes;Genetic;Glycoproteins;granulocyte;Guidelines;healthy volunteer;Heart;Human;human subject;Immune;Immunophenotyping;In Vitro;induced pluripotent stem cell;Inflammation;Inflammatory;inflammatory marker;Institution;Institutional Review Boards;Journals;Kinetics;Laboratories;Life;Lipopolysaccharides;Lung;Lymphocyte;Maintenance;Medicine;member;Molecular;Natural Killer Cells;neutrophil;Neutrophil Activation;new therapeutic target;novel marker;operation;Paper;Patients;Peripheral Blood Mononuclear Cell;Plasma;Plasma Cells;Printing;Protocols documentation;Publishing;pulmonary arterial hypertension;Pulmonary Heart Disease;Relapsing polychondritis;Renal Replacement Therapy;Reporting;Research;Research Personnel;research study;Research Subjects;response;RNA;Role;Sampling;Sepsis;Severity of illness;SYK gene;symposium;Therapeutic;Thrombelastography;Thrombosis;Translational Research;Ultrafiltration;United States National Institutes of Health;Urine;Vascular Diseases;Viral Proteins;Virus Shedding;Western Blotting;Whole Blood

PROJECT_TITLE: Obtaining Samples from Human Subjects to Facilitate Basic, Translational and Clinical Research


PI_NAMEs: ROSENZWEIG, SERGIO  (contact)

PROJECT_TERMS: Address;Clinical Research Protocols;congenital immunodeficiency;cost effective;Data;Defect;Dideoxy Chain Termination DNA Sequencing;Disease;DNA Resequencing;exome sequencing;experience;Fluorescent Probes;FOXP3 gene;Future;Genes;genome sequencing;Genomic DNA;Host Defense;Hyperimmunoglobulin M Syndrome;IFNGR1 gene;IL7R gene;Immune System Diseases;immunodeficiency;Immunologic Deficiency Syndromes;Interleukin 2 Receptor Gamma;interleukin-12 receptor;Ions;JAK3 gene;Lymphoid;Methods;Mutation;Mutation Analysis;mutation screening;National Human Genome Research Institute;next generation sequencing;novel;Organism;patient screening;Patients;Receptors, Adrenergic, beta-1;recurrent infection;screening;Series;Techniques;Testing;TNFSF5 gene;United States National Institutes of Health;web site;whole genome;Wiskott-Aldrich syndrome protein;Work

PROJECT_TITLE: Mutation Analysis Of Selected Lymphoid Immune Disorders


PI_NAMEs: LAU, ANNA  (contact)

PROJECT_TERMS: Adopted;Awareness;Biological Products;Cell Therapy;Clinical;Clinical Microbiology;Collaborations;comparative;Cyclic GMP;Data;Dental;Detection;diagnostic platform;Dialysis procedure;Disease;Ensure;Environmental Monitoring;Equipment;Evaluation;Event;Faculty;falls;Goals;Industry;Infusion procedures;International;Laboratories;Letters;Light;Manuscripts;Maryland;Methods;Mucor;Multicenter Studies;Mycoplasma;novel diagnostics;novel therapeutics;Patients;Pharmaceutical Preparations;Pharmacy facility;programs;Qualifying;Regulation;Ribosomal DNA;Safety;Sampling;sterility testing;symposium;T-Lymphocyte;Testing;United States National Institutes of Health;Universities;water testing

PROJECT_TITLE: Novel Diagnostic Platforms for Sterility Testing of Cellular Therapies and Biopharmaceutical Products


PI_NAMEs: SACKS, DAVID  (contact)

PROJECT_TERMS: Address;Algorithms;alpha helix;Amino Acids;Area;Back;Binding;Biological;Branched-Chain Amino Acids;Breast;Calmodulin;Calmodulin-Binding Proteins;Cancerous;Cell Adhesion;cell motility;Cell Physiology;Cell Proliferation;Cells;Cirrhosis;clinical diagnosis;Compensation;Complex;Data Set;Degradation Pathway;Development;Down-Regulation;Eating;EGF gene;Electrostatics;Epidermal Growth Factor Receptor;ERBB2 gene;Evaluation;expectation;experimental study;Extracellular Signal Regulated Kinases;Fibrosis;Goals;Growth Factor;Hepatic;Hepatitis C virus;Homeostasis;Hydrophobic Interactions;Impairment;in silico;insight;instrument;Ions;KSR gene;Label;Laboratories;Liquid Chromatography;Liver;liver biopsy;Liver diseases;liver function;Malignant - descriptor;mass spectrometer;Measures;Mediating;Metabolic;Methods;microbial;microorganism;migration;Mitogen-Activated Protein Kinases;Modeling;Molecular;Molecular Conformation;molecular modeling;Multiprotein Complexes;Muscle;mutant;Mutation;Neoplastic Cell Transformation;Neurites;Normal Cell;Organ Size;overexpression;pathogen;Pathogenesis;Pathway interactions;Patients;Peripheral;Play;Process;Proteins;Proteomics;Public Health;Publishing;Regulation;Reporter;Research;Role;Running;Safety;Sampling;sarcopenia;Scaffolding Protein;Second Messenger Systems;Sensitivity and Specificity;Shunt Device;Signal Pathway;Signal Transduction;Site-Directed Mutagenesis;Specificity;stressor;structural determinants;Surgical Portosystemic Shunt;tandem mass spectrometry;Time;Tissues;tool;transcriptome;tumor;tumorigenesis;Urinary tract;Veins;Work

PROJECT_TITLE: IQGAP1 in tumorigenesis


PROJECT_TERMS: Activities of Daily Living;Adult;Age;Algorithms;American;Angiography;antagonist;Antiinflammatory Effect;Apoptotic;Autoimmune Diseases;Biological;Biological Markers;biomarker identification;bisulfite sequencing;Blood;Blood specimen;Blood Vessels;Bone Marrow;Breast;Cardiac;Cardiac Catheterization Procedures;cell free DNA;Cells;Cessation of life;Chest;Chronic;circulating biomarkers;Circulation;Clinical;clinical center;Clinical Data;clinical predictors;clinical translation;clinically relevant;Coagulation Process;cohort;Collaborations;comparison control;congenital heart abnormality;Control Groups;Coronary Arteriosclerosis;Coronary artery;Creatinine;Data;Data Analyses;Diagnosis;Diagnostic;differential expression;Disease;Disease Marker;disease prognosis;Disease Progression;DNA Methylation;Double-Blind Method;Echocardiography;Endothelial Cells;endothelial dysfunction;Endothelium;Enrollment;Epigenetic Process;Evolution;exercise capacity;Expression Profiling;extracellular;Fibrinolysis;Fibrosis;Flow Cytometry;follow up assessment;Functional disorder;Functional impairment;Future;Gender;Gene Expression Profile;Generations;Genes;Genetic;genetic signature;genome-wide;Goals;Gynecomastia;healthy volunteer;Heart failure;heart imaging;Hematology;Hematopoietic stem cells;hemodynamics;Histopathology;HIV Infections;Hospitalization;hyperkalemia;Hypoxemia;Imaging Techniques;improved;Incidence;Individual;Inflammation;Inflammation Mediators;Injury;injury and repair;innovation;interest;International;Intervention Trial;Kidney Failure;Kinetics;Left;Liver diseases;Lung;Lung Diseases;lung pressure;lung vascular injury;Magnetic Resonance Imaging;Manuscripts;material transfer agreement;Measurement;Measures;Medical;Meta-Analysis;Metabolic;Methodology;Mineralocorticoid Receptor;Mixed Connective Tissue Disease;mortality;National Heart, Lung, and Blood Institute;Natural History;neutrophil;new therapeutic target;novel;novel marker;novel therapeutics;open data;Outcome;Oxygen Consumption;Pain;Pathogenesis;patient oriented;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phase;Phenotype;Pilot Projects;Placebo Control;Placebos;Plasma;Plasma Cells;Population;Portal Hypertension;Potassium;primary endpoint;primary pulmonary hypertension;pro-brain natriuretic peptide (1-76);Process;prognostic value;programs;Protocols documentation;Publishing;pulmonary arterial hypertension;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular remodeling;Pulmonary veins;Randomized;Reporting;research clinical testing;Resolution;right ventricular failure;Right Ventricular Function;Right ventricular strain;Risk Factors;risk prediction;risk stratification;RNA;Safety;Sampling;secondary endpoint;Series;Serum;Severity of illness;Side;side effect;Societies;Source;Spironolactone;stem cells;study population;Surrogate Markers;symposium;Symptoms;systemic inflammatory response;Systemic Lupus Erythematosus;Systemic Scleroderma;T-Lymphocyte;Testing;therapeutic target;Thrombelastography;Thrombosis;Time;tissue mapping;Tissues;transcriptomics;translational research program;Transplantation;Treatment Efficacy;treatment group;treatment response;trend;United States National Institutes of Health;Validation;vascular inflammation;Vascular remodeling;Ventricular;VO2max;Walking;X-Ray Computed Tomography

PROJECT_TITLE: Clinical Translational Research Program in Pulmonary Arterial Hypertension (PAH): Disease Mechanisms, Biomarkers, and Novel Therapeutic Targets


PROJECT_TERMS: Accounting;Acute;Adoptive Transfer;Alloantigen;allograft rejection;Allograft Tolerance;Allografting;Animal Model;Animals;antibody-mediated rejection;base;biobank;Biological Markers;biomarker discovery;biomarker identification;Biopsy;Blood;Blood Vessels;candidate marker;Cardiac Catheterization Procedures;cell free DNA;Cell Therapy;Cells;Cessation of life;chromatin immunoprecipitation;Chronic;Clinical;clinical phenotype;cohort;Collaborations;computerized data processing;Consensus;Cyclosporine;cytokine;Data;Data Analyses;Data Set;Databases;Derivation procedure;design;Detection;diagnosis standard;diagnostic biomarker;Diagnostic tests;diagnostic tool;Disease;Dose;drug development;Dyspnea;Energy Metabolism;Enrollment;Escherichia coli;Fatigue;follow-up;functional genomics;Future;Gene Expression;Genes;genetic signature;Genomic approach;Genomics;Genotype;Goals;Harvest;healthy volunteer;Heart;heart allograft;Heart failure;Heart Transplantation;Histocompatibility Antigens;Histologic;histological slides;Histopathology;human study;Image;Immune system;Immune Tolerance;Immunologics;Immunosuppression;Immunosuppressive Agents;Inbred BN Rats;Incidence;Infection;Inflammation;Inflammatory;Injections;Injury;Investigation;Libraries;Life;Liver;Low Grade Fever;Lung;Lymphocyte;Lymphoid Cell;Maintenance;Malignant Neoplasms;Manuscripts;Metabolic;Methods;methylation pattern;Microarray Analysis;Modeling;Morbidity - disease rate;mortality;nanotechnique;National Heart, Lung, and Blood Institute;novel;open data;Operative Surgical Procedures;Organ Donor;Organ Survival;Organ Transplantation;participant enrollment;Pathogenesis;Pathologist;Pathway interactions;Patients;Pattern;Peptides;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phenotype;physical property;Plasma;pneumonia model;post-transplant;predictive marker;preservation;Preventive therapy;Procedures;Process;programs;Proteins;Proteomics;protocol development;Protocols documentation;Publishing;Randomized;Rattus;Regulatory Pathway;Regulatory T-Lymphocyte;Reporting;Research;Research Design;Risk;RNA;Saline;sample collection;Sample Size;Sampling;Scheme;Series;Serum;Sirolimus;Solid;Source;Specificity;Specimen;Spleen;Splenocyte;sudden cardiac death;Symptoms;T-Lymphocyte;Techniques;Testing;Th2 Cells;Therapeutic immunosuppression;Thymus Gland;Time;Tissues;Training;transplant model;Transplant Recipients;Transplantation;ultrasound;United States National Institutes of Health;Urine;Validation;Vascular Diseases;Ventricular

PROJECT_TITLE: Heart Transplantation Research:  Investigation into Cardiac Allograft Rejection


PI_NAMEs: FRANK, KAREN  (contact)

PROJECT_TERMS: Adherence;Adult;Age;Agreement;arm;Automobile Driving;Behavior;Biochemical;Biological;Biological Assay;Biological Markers;Blood;Blood specimen;clinical center;cohort;Consumption;cooking;Cross-Over Studies;data submission;Diet;dietary;dietary adherence;Dietary History;Dietary Intervention;Disease;Eating;Electronics;Feces;Female;Food;Gender;Geographic Locations;gut microbiome;gut microbiota;Health;Health Benefit;healthy volunteer;inclusion criteria;Individual;Intake;Intervention;Intervention Studies;Interview;Longitudinal cohort;Longitudinal Studies;male;Measures;Medical History;Mediterranean Diet;meetings;Metabolic;microbiota composition;nutrition;Outpatients;Paper;Participant;Perceived quality of life;Periodicals;Personal Satisfaction;Persons;Phase;primary endpoint;Psychosocial Factor;Questionnaires;Randomized;recruit;Research Design;Ribosomal RNA;Role;Sample Size;Sampling;Schedule;screening;secondary endpoint;Shotgun Sequencing;Specimen;stool sample;Surveys;telehealth;Telephone;tool;United States National Institutes of Health;Urine;Visit;volunteer;western diet

PROJECT_TITLE: Mediterranean-like Unprocessed (CLEAN-MED) Diet Intervention Study of the Gut Microbiome of Healthy Adults


PROJECT_TERMS: acceptability and feasibility;Adult;Aging;Allogenic;alpha-amylase;American;Anxiety;Area;arm;Biological Markers;cardiometabolism;care recipients;Caregivers;caregiving;Caring;Clinical;clinical center;design;effectiveness evaluation;Emerging Technologies;Enrollment;experience;Family Caregiver;Family member;Fatigue;follow-up;Friends;Health;health care settings;Hematopoietic Stem Cell Transplantation;Hydrocortisone;Impaired cognition;Inflammatory;Institutional Review Boards;Intervention Studies;Interview;Malignant Neoplasms;Mental Depression;Nature;Osteocalcin;Oxytocin;Participant;Patients;perceived stress;Persons;Phase;phase 1 study;phase 2 study;Pilot Projects;Population;primary caregiver;primary outcome;prospective;Psychological Stress;Publishing;Randomized;recruit;Reporting;Role;secondary outcome;Sleep disturbances;sound;Stress;stress management;Symptoms;Therapeutic;Transplant Recipients;Transplantation Conditioning;United States National Institutes of Health;virtual reality;virtual reality headset;virtual reality intervention

PROJECT_TITLE: A pilot study of a nature-based virtual reality (VR) intervention in family caregivers of allogeneic hematopoietic stem cell transplant (HSCT) recipients


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

PI_NAMEs: KACHAR, BECHARA  (contact)

PROJECT_TERMS: 3-Dimensional;Actins;Adult;Affect;Aging;Anatomy;Antibodies;Architecture;arm;Auditory;Automobile Driving;Binding;Biogenesis;Biological Assay;Biological Models;CBA/J Mouse;Cell Nucleus;Cell Separation;cell type;Cells;Cellular Structures;Characteristics;Cilia;cilium biogenesis;cilium motility;Cochlea;Collaborations;comparative;Complex;COS-7 Cell;Cryo-electron tomography;Cryoelectron Microscopy;Cytoskeleton;Data;deafness;density;design;Development;differential expression;Disease;Dynein ATPase;Electron Microscopy;Encapsulated;Ependymal Cell;Epidermal Growth Factor Receptor Pathway Substrate 8;Epithelium;Exhibits;Family;Filopodia;Flagella;Generations;Genes;genetic regulatory protein;Goals;Hair;Hair Cells;hearing impairment;Homeostasis;Image;Immunofluorescence Immunologic;immunoreactivity;In Situ;information gathering;inner ear diseases;Inner Hair Cells;innovation;Investigation;Kinocilium;Label;Laboratories;Labyrinth;Length;lens;Life;light microscopy;Link;Lipids;Location;Maintenance;Mammalian Cell;Maps;mechanotransduction;member;Membrane;Messenger RNA;Methodology;Methods;Microscopy;Microtubules;Modeling;Molecular;Morphology;Motility;Multivesicular Body;Mus;Mutation;nanoDroplet;Nature;nexin;normal hearing;old mice;Organ;Organ of Corti;Organelles;Organism;Outer Hair Cells;particle;Phase;Physical condensation;Point Mutation;Positioning Attribute;preventive intervention;Process;programs;Property;Protein Databases;Proteins;Proteolipids;Radial;Rattus;Recycling;Regulation;Reporting;Research;residence;Resolution;Respiratory Diaphragm;RFX3;Role;self organization;Semicircular canal structure;Sensory;Sensory Hair;Series;Shapes;Sorting;Source;spatiotemporal;sperm cell;Stereocilium;Structure;Testing;Therapeutic Intervention;Tissues;Tomogram;Trachea;Transcript;Transcriptional Regulation;transcriptome;transcriptomics;Type I Hair Cell;Type II Hair Cell;Universities;Variant;Vesicle;Vestibular Hair Cells;vestibular system;virtual;Visualization;ward

PROJECT_TITLE: Structural and Molecular Basis of Transduction in Auditory Sensory Organs


ORG_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

PI_NAMEs: MORELL, ROBERT J (contact)

PROJECT_TERMS: Alternative Splicing;causal variant;cell type;Cells;Cochlea;Code;Collection;Data Set;deafness;Disease;DNA sequencing;Elements;Epigenetic Process;Exons;Family;Gene Expression Regulation;Genes;Genomics;Goals;Hair Cells;hearing impairment;hereditary hearing loss;Human;interest;Labyrinth;Mammals;Molecular;Mus;Mutation;mutation screening;National Institute on Deafness and Other Communication Disorders;novel;Pattern;protein function;Protein Isoforms;Proteins;Research;Research Personnel;RNA;RNA Splicing;Role;Sampling;segregation;Sorting;Specificity;spiral ganglion;Stria Vascularis;Techniques;Tissues;Transcript;transcriptome;Untranslated Regions;Utricle structure;validation studies

PROJECT_TITLE: Molecular and Epigenetic Mechanisms of Hereditary Hearing Loss


NIH_SPENDING_CATS: Neurosciences

PI_NAMEs: WEISZ, CATHERINE  (contact)

PROJECT_TERMS: Acoustic Trauma;Acoustics;Afferent Neurons;Anatomy;Animal Model;Aromatase;Auditory;auditory pathway;Auditory Perception;Auditory system;Automobile Driving;Back;Basilar Membrane;Brain;brain pathway;Brain Stem;Categories;Cell Nucleus;Cells;cholinergic;Cochlea;Cochlear Nerve;Cochlear nucleus;Communication;Complement;Complex;Computer Models;Computing Methodologies;Coupling;Data;Dendrites;Detection;Ear;Efferent Neurons;Electric Conductivity;electrical property;Electrophysiology (science);experimental study;falls;Fluorescence;Genetic;Genetic Techniques;Goals;Hair Cells;Hearing;Histological Techniques;Hyperactivity;Hyperacusis;Imaging Techniques;Immunohistochemistry;improved;In Vitro;in vivo;Internal Ribosome Entry Site;Journals;Knowledge;knowledge integration;Laboratories;Lateral;live cell imaging;Manuscripts;Measures;Mechanics;Medial;Medical;Medical Records;meetings;Methods;Modeling;Molecular Biology;Morphology;Movement;Mus;Nervous System;neural circuit;neuronal circuitry;Neurons;neurotransmitter release;Neurotransmitters;Noise;novel;Optics;optogenetics;Output;patch clamp;Pathologic;Pathway interactions;Perception;Physiology;postsynaptic;Potassium;Preparation;Printing;Property;Proteins;Publications;Publishing;Reporting;Research;response;Role;Serotonergic System;Serotonin;Shapes;Signal Transduction;Slice;sound;Speech;spiral ganglion;Synapses;Synaptic plasticity;Synaptic Potentials;Synaptic Transmission;System;Techniques;Testing;Tinnitus;tool;transcriptomics;trapezoid body;Trauma;Work

PROJECT_TITLE: Synaptic Circuitry of Auditory Neurons


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Transplantation

PI_NAMEs: ROBEY, PAMELA G (contact)

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Address;Adipocytes;Adoptive Transfer;Affect;articular cartilage;Behavior;Biological;Biological Assay;Biology;Bioreactors;Blood Cells;blood formation;BMP2 gene;bone;Bone Marrow;Bone Regeneration;bone resorbing activity;bone turnover;burden of illness;Cartilage;Cartilage Diseases;cartilage regeneration;cartilage repair;CD34 gene;cell type;Cells;Cephalic;Characteristics;Chondrocytes;Chondrogenesis;circulating biomarkers;Clinical;Clinical Trials;Coculture Techniques;Collection;Complement;Connective Tissue;craniofacial;Culture Media;Cyclic AMP;cytokine;Cytokine Signaling;Data;Defect;Deposition;Diameter;Dinoprostone;Disease;Embryo;Enzyme-Linked Immunosorbent Assay;Epiphysial cartilage;Exhibits;Exogenous Factors;experimental study;Extracellular Matrix;face bone structure;Fibrin;Fibrous Dysplasia;GDF5 gene;Gene Expression;Gene Modified;Gene Silencing;Genetic Diseases;Genetic Markers;genetic signature;Glycosaminoglycans;Goals;growth differentiation factor 5;Growth Factor;Health;healthy volunteer;Hematopoietic;hematopoietic stem cell formation;Hematopoietic stem cells;Hip region structure;Homeostasis;Human;human embryonic stem cell;human induced pluripotent stem cells;Hyaline Cartilage;Hyaluronic Acid;Hypertrophy;IGFBP5 gene;IL6 gene;Immune;Immunocompromised Host;immunoregulation;Immunosuppression;Impairment;In Vitro;in vivo;Inflammatory;Interleukin-10;Intrinsic factor;Lateral;Lesion;Lipids;long bone;Macrophage;Maintenance;Marrow;Measures;Mediator;member;Mesenchymal Stem Cells;Mesoderm;Metabolism;Microspheres;mineralization;Mixed Lymphocyte Culture Test;Monitor;monocyte;Monocytic leukemia;monolayer;mosaic;mouse model;Mus;Mutation;Myelogenous;Neural Crest;Neuroectoderm;Organ;Organoids;Osteitis Fibrosa Disseminata;Osteoblasts;Osteoclasts;Osteogenesis;osteogenic;Outcome;Paraxial Mesoderm;Pathway interactions;Patients;Periosteum;Phenotype;Plasma;Play;Population;postnatal;preclinical study;Preparation;Process;Production;programmed cell death ligand 1;reconstruction;Regenerative Medicine;Reporting;response;restoration;restraint;Rodent;Role;Sampling;Sclerotome;Signal Transduction;skeletal;skeletal abnormality;skeletal disorder;skeletal stem cell;Skeleton;small hairpin RNA;Source;spheroids;stem cell therapy;stem cells;Stromal Cells;Structure;Study Section;Surgical sutures;T-Cell Proliferation;targeted biomarker;Techniques;TGFB1 gene;therapeutic target;Time;Tissue Engineering;Tissues;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;Transplantation;Vacuole;Variant;Yolk Sac

PROJECT_TITLE: The role of stem cells in skeletal health and disease


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Genetics;Immunotherapy

ORG_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

PI_NAMEs: WARNER, BLAKE  (contact)

PROJECT_TERMS: Acinar Cell;Address;Affect;Agonist;Area;Autoimmune Diseases;Autoimmunity;Autonomic nervous system;Biological;Biology;biomarker identification;Biopsy;Body System;Calcium;cancer therapy;candidate marker;Cell Physiology;cell type;Cell Volumes;Cells;checkpoint inhibition;Classification;Clinic;Clinical;Clinical Data;clinical phenotype;Clinical Research;Collaborations;Collection;Complex;Confocal Microscopy;COVID-19 pathogenesis;Data;Defect;design;Development;Diagnosis;Disease;Drug Targeting;Ductal Epithelial Cell;Endocrinology;Epithelial Cells;experience;Fluids and Secretions;Functional disorder;Functional Imaging;Future;Gene Modified;Genetic;genetic analysis;Genetic Materials;Genetic Transcription;Gland;Goals;Health;healthy volunteer;High-Throughput Nucleotide Sequencing;Iatrogenesis;immune activation;Immune checkpoint inhibitor;Immune system;immune-related adverse events;Immunology;immunopathology;Immunotherapy;improved;Individual;Inflammation;insight;interest;Investigation;Laboratories;Laboratory Study;laser capture microdissection;Lymphocyte;Malignant Neoplasms;Masks;Measures;medical specialties;Medicine;Methods;Minor salivary gland structure;molecular imaging;Molecular Profiling;Mutation;Natural History;Nature;novel;novel marker;novel therapeutics;Oral cavity;Organ;Outcome;Parotid Gland;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;patient subsets;Patients;PD-1/PD-L1;Phenocopy;Phenotype;Prevention;Prognosis;Proteins;Rare Diseases;receptor;Research;research clinical testing;Research Project Grants;Role;Salivary;salivary cell;Salivary Gland Diseases;Salivary Glands;Sampling;Scientist;Severities;single-cell RNA sequencing;Sjogren's Syndrome;Source;Specimen;Structure;Syndrome;T-Lymphocyte Subsets;Therapeutic;Time;Tissue Sample;Tissues;transcriptome;transcriptome sequencing;tumor;Variant;Xerostomia

PROJECT_TITLE: Clinical and Mechanistic Investigations of Salivary Gland Dysfunction


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Diabetes;Genetics;Human Genome;Obesity;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: COLLINS, FRANCIS S. (contact)

PROJECT_TERMS: Adipose tissue;Adult;Affect;Alleles;ATAC-seq;Beta Cell;Biological Assay;Biopsy;Blood Pressure;Brain;Cadaver;candidate identification;Cell Differentiation process;Cell Line;Cell Physiology;Cell Survival;cell type;Cells;Cessation of life;Chromatin;Chronic Disease;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;Collaborations;comparison control;Complement;Complex;cytokine;Data;data integration;Data Set;Development;Diabetes Mellitus;diabetes mellitus genetics;diabetes risk;diabetic;Diagnosis;Diet;Disease;disorder risk;DNA Integration;DNA Methylation;endocrine pancreas development;Enhancers;Environmental Risk Factor;Epigenetic Process;epigenome;epitranscriptome;exome sequencing;experimental study;fasting glucose;Foundations;Gene Expression;Gene Mutation;Genes;Genetic;genetic analysis;genetic association;Genetic Identity;Genetic Transcription;genome sequencing;genome wide association study;genomic data;Genomics;Genotype;Glucose;glucose tolerance;Goals;Height;Heterozygote;High Density Lipoprotein Cholesterol;high-throughput drug screening;HNF4A gene;Homeostasis;Human;human embryonic stem cell line;Hypothalamic structure;Immunofluorescence Immunologic;impaired glucose tolerance;In Vitro;Individual;induced pluripotent stem cell;Inflammatory;Inherited;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans;Knock-out;Laboratories;LDL Cholesterol Lipoproteins;Link;Lipids;Liver;Machine Learning;Measures;Medicine;men;Meta-Analysis;Metabolic;Metabolism;metabolomics;MicroRNAs;Modeling;Modification;Molecular;multiple omics;Muscle;Mutation;nanopore;National Center for Advancing Translational Sciences;Neuronal Differentiation;Neurons;New York;Non-Insulin-Dependent Diabetes Mellitus;Nucleic Acid Regulatory Sequences;Obesity;OGTT;Paint;Pancreas;pancreas development;Phenotype;Physiological;Plasma;Play;Population;preservation;Prevention;prime editing;Process;Production;progenitor;Proinsulin;promoter;Proteomics;Protocols documentation;Quantitative Trait Loci;rare variant;Reading;Research;response;Risk;risk variant;RNA;Role;Sampling;Series;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Site;Skeletal Muscle;Skin;Stains;stem cells;Stress;Structure of beta Cell of islet;Technology;Testing;Time;Tissue-Specific Gene Expression;Tissues;trait;Transcript;transcriptome sequencing;transcriptomics;Triglycerides;Untranslated RNA;Validation;Variant;Viral;whole genome

PROJECT_TITLE: Genetic analysis of type II diabetes


NIH_SPENDING_CATS: Aging;Biotechnology;Cardiovascular;Clinical Research;Gene Therapy;Genetics;Heart Disease;Human Genome;Orphan Drug;Pediatric;Rare Diseases

ORG_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

PROJECT_TERMS: 5' Splice Site;Adenine;adeno-associated virus 9 delivery;Age;Age Months;Aging;aging process;Amino Acids;Antisense Oligonucleotides;Aorta;Arterial Fatty Streak;ATAC-seq;base;base editing;base editor;beta-Galactosidase;Biological Assay;Biological Markers;Biological Sciences;Birth;Blood Vessels;bone;Bone remodeling;Bulla;Bystander Effect;C10;Cardiac;Cardiovascular system;Cell Culture Techniques;Cell Cycle;cell free DNA;Cell Line;cell type;Cells;Cessation of life;Child;Chimeric Proteins;Chromatin;Chromosome Segregation;Chromosome Structures;clinical biomarkers;Clinical Trials;clinically relevant;Clone Cells;Code;Collaborations;comparative;Complementary DNA;Critical Pathways;Deaminase;Defect;Deposition;Dermis;Development;Developmental Bone Diseases;disease phenotype;Disease Progression;DNA;DNA Sequence;DNA sequencing;Doctor of Philosophy;Dominant-Negative Mutation;Dose;Echocardiography;Ectopic Expression;Elements;Engineering;Epigenetic Process;Exhibits;Exons;extend lifespan;Extracellular Matrix;Family;Farnesyl Transferase Inhibitor;farnesylation;Fibroblasts;first-in-human;Formulation;Foundations;Functional disorder;Future;gene correction;Gene Delivery;gene editing technology;Gene Expression Profiling;gene product;gene therapy;gene-targeted therapy;Genes;Genetic;Genetic Models;Genetic Transcription;genetic variant;Growth;Heart Abnormalities;Heart failure;heart function;Hela Cells;Heterozygote;Histones;Human;Impairment;improved;In Vitro;in vivo;induced pluripotent stem cell;Injections;intein;intravenous injection;Investigation;Laboratories;Lamin Type A;Left ventricular structure;Lentivirus Vector;life span;Liver;Lonafarnib;Mechanics;medical schools;Messenger RNA;methylation pattern;mineralization;Molecular;mortality;mouse model;Mus;Muscle Cells;mutant;Mutation;mutation correction;Myocardial Infarction;Myocardium;Names;nanopore;next generation;novel;novel therapeutic intervention;Nuclear;Nuclear Lamina;Nuclear Matrix;Nucleotides;Oligonucleotides;Organism;Osteoblasts;Pathology;Patients;Pediatric Hospitals;Pennsylvania;Peptides;Pharmacologic Substance;Phenotype;Philadelphia;Plasma;potential biomarker;pre-clinical;preclinical trial;Premature aging syndrome;Production;Progeria;programs;Proliferating;promoter;Protein Truncation;Proteins;rare condition;Rare Diseases;Research;response;RNA;RNA Splicing;Sampling;Severity of illness;Signal Pathway;Signal Recognition Particle;Site;Skeletal Muscle;Smooth Muscle Myocytes;Solid;Stains;standard of care;Stroke;Structure;Subcutaneous Injections;Syndrome;System;Testing;Therapeutic;therapeutic gene;therapeutic genome editing;Therapeutic Intervention;Tissues;Toxic effect;transcriptome;transcriptome sequencing;Transfection;Transgenes;Transgenic Mice;Translating;Translations;treatment response;United States National Institutes of Health;Universities;Up-Regulation;Validation;Vascular Smooth Muscle;vector;Viral;Viral Genome;working group

PROJECT_TITLE: Hutchinson-Gilford Progeria syndrome--a model for the genetics of aging.


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Neurosciences;Pediatric

PROJECT_TERMS: abducens nerve;Affect;affection;Age;Amygdaloid structure;Area;Atrophic;Autopsy;autosome;Award;Bilateral;Binding;Biological Models;Birth;Blood;Boston;Brain;brain control;Brain imaging;brain magnetic resonance imaging;Brain Stem;calcification;Candidate Disease Gene;Carey-Fineman-Ziter syndrome;Caring;Case Study;Cell Line;Cell Nucleus;cell type;Cephalic;CHD7 gene;Child;Chromatin;clinical database;clinical phenotype;Code;cohort;Collaborations;Communication;comparison control;Complex;Cranial Nerves;craniofacial;Data;Data Analyses;de novo mutation;Dedications;Deformity;Dental;Deubiquitinating Enzyme;Development;Diagnosis;diagnostic criteria;Disease;disease-causing mutation;DNA;DNA Sequencing Facility;Efferent Neurons;Electrophysiology (science);Embryonic Development;Emotions;Enhancers;Enrollment;Environmental Risk Factor;ethnic diversity;Ethnic Population;Etiology;exome;exome sequencing;Eye;Face;Facial Muscles;Facial nerve structure;Facial paralysis;Facial Paresis;Family;Family history of;Family member;follow-up;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Gender;Gene Frequency;Genes;Genetic;Genetic study;genetic variant;Genome;genome analysis;genome sequencing;Germ Lines;Germ-Line Mutation;Gliosis;Goals;Grant;Heterogeneity;Heterozygote;Horizontal Disease Transmission;horizontal gaze;Human;Impairment;Incidence;Individual;Inherited;insertion/deletion mutation;interdisciplinary approach;Ipsilateral;Labyrinth;Limb structure;Location;Manuscripts;Mechanics;MEPE gene;morphometry;Motor;Motor Neurons;mouse model;Movement;multimodality;Mus;Mutate;Mutation;Myoblasts;Myopathy;National Human Genome Research Institute;National Institute of Biomedical Imaging and Bioengineering;National Institute of Dental and Craniofacial Research;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;Nature;nerve stem cell;Netherlands;neuroblastoma cell;neuronal circuitry;New Zealand;Nuclear Import;offspring;Oral health;Organ;Parents;Participant;Pathogenesis;Pathology;Pathway interactions;patient registry;Patients;Pediatric Research;Phenotype;Piezo 2 ion channel;POU2F1 gene;prenatal environmental exposure;proband;programs;Protocols documentation;Public Health;Publishing;Quality of life;Regulatory Element;Reporting;Research;Research Project Grants;Resources;Role;Sampling;segregation;Sensory;Shapes;Siblings;Side;Single Nucleotide Polymorphism;Site;Skeletal Development;social;Somatic Mutation;Somatosensory Evoked Potentials;Standardization;Structure;Susceptibility Gene;Syndrome;System;Texas;ubiquitin isopeptidase;United States National Institutes of Health;Universities;Untranslated RNA;Utah;Variant;variant of unknown significance;Vascular blood supply;Vibrissae;whole genome;Work;Zebrafish

PROJECT_TITLE: Genetics of Moebius syndrome and other congenital facial weakness disorders


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PI_NAMEs: SADHU, MERU  (contact)

PROJECT_TERMS: Arkansas;Binding;Biology;Catalytic Domain;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;CRISPR/Cas technology;Genes;Genetic;genetic information;Genetic study;genetic variant;Genetic Variation;Genome engineering;Genomics;Genotype;Goals;Human;Immune;Individual;interest;Learning;Link;Medicine;Methods;Mutagenesis;Mutation;mutation screening;novel;Oligonucleotides;Phenotype;Printing;Proteins;Reporting;resilience;System;Systems Biology;Universities;Variant;vector;Virus Inhibitors;Work;Yeast Model System;Yeasts

PROJECT_TITLE: High-throughput genome engineering


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

PI_NAMEs: GUNTER, CHRISTIE  (contact)

PROJECT_TERMS: Ableist;adult with autism spectrum disorder;Affect;Applied Genetics;autism spectrum disorder;autistic;autistic children;Behavioral Research;Communication;Communities;Complex;Comprehension;Critiques;Decision Making;design;Development;Diagnosis;Diagnostic tests;disability;disabled;Disabled Persons;Education;Effectiveness;Elements;Environment;Ethics;experience;Exposure to;Face;Familiarity;Feedback;Funding;General Population;Genetic;genetic information;genetic testing;Genomics;Grant;Individual;individuals with autism spectrum disorder;interest;Intervention;Knowledge;Language;Life;literacy;mathematical ability;Measurement;Measures;Medical;member;Methods;Morbidity - disease rate;mortality;National Human Genome Research Institute;Pain;Participant;Pathology;Personal Satisfaction;Persons;Population;Population Genetics;preference;Prevalence;Provider;Psychometrics;Published Comment;Reporting;Research;Research Personnel;research study;Respondent;Rural;Sampling;Science;Secondary Schools;Series;skills;social;social expectations;social stigma;Societies;Stigmatization;Surveys;United States National Institutes of Health;Update;Validation;Work

PROJECT_TITLE: Genetics and Autism Literacy Survey (GALS)


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Human Genome;Nutrition;Patient Safety;Pediatric;Precision Medicine;Rare Diseases;Sickle Cell Disease

PI_NAMEs: HANCHARD, NEIL  (contact)

PROJECT_TERMS: Acute;Africa;African;African ancestry;Agreement;Annual Reports;Antibodies;beta Globin;Birth History;bisulfite;Blood specimen;Carbon;Cell model;Cells;Child;Childhood;Chromosomes;clinical center;clinical phenotype;Clinical Protocols;Clinical Research;cohort;Collaborations;Complex;Computational Biology;Country;Data;Data Collection;design;Development;Disease;DNA;DNA Methylation;DNA sequencing;electronic data;Epidemiology;Erythrocytes;exome;Fatty acid glycerol esters;Fatty Liver;Forms Controls;Functional disorder;Funding;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic epidemiology;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome sequencing;genome wide association study;genome-wide;genomic locus;Genomic Segment;Genomics;Hemoglobin;High Prevalence;Human;Human Genetics;Human Genome;human genomics;human reference genome;Immune response;Income;Individual;Institutional Review Boards;International;Knowledge;Kwashiorkor;LGR5 gene;Linguistics;Malnutrition;Manuscripts;meetings;Metabolic;Metabolism;metabolomics;Modernization;Molecular;molecular phenotype;multiple omics;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;novel;organizational structure;Participant;Pathway interactions;Patients;Persons;Phenotype;Population;population based;Population Genetics;Population Heterogeneity;Process;Proteins;Publications;Publishing;Reaction;Recontacts;recruit;Reporting;repository;Research;Research Personnel;research study;Risk;risk variant;RNA;Sampling;Schedule;Sickle Cell Anemia;single cell sequencing;Single Nucleotide Polymorphism;Site;Spleen;Starvation;Statistical Data Interpretation;Sterile coverings;Technology;telomere;Testing;Therapeutic;Time;tool;trait;Transfusion;Uganda;United States National Institutes of Health;Variant;Vendor;whole genome;Work

PROJECT_TITLE: Multi-omics Studies of Childhood Complex Traits in Diverse Populations


PROJECT_TERMS: Adolescent;African;Blood Pressure;blood pressure elevation;Candidate Disease Gene;Cell model;Child;Childhood;Clinical;cohort;Collaborations;Communities;comorbidity;Data;Disease;DNA sequencing;Essential Hypertension;Ethics;Etiology;Family;Gene Expression;Genes;Genetic;genetic variant;Genetic Variation;Genome;genome analysis;genome sequencing;Goals;Heritability;high risk;Hypertension;in vivo Model;Individual;Inherited;Kidney Failure;Low Prevalence;Measures;Molecular;Natural History;Parents;Pathogenesis;Pathway interactions;Phenotype;Proteins;Protocols documentation;recruit;Reporting;Risk;Sampling;Stroke;Testing;Therapeutic Intervention;Variant

PROJECT_TITLE: Genetics of childhood-onset hypertension


NIH_SPENDING_CATS: Cardiovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Human Genome;Hypertension;Infectious Diseases;Lung;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

PI_NAMEs: DENNY, JOSHUA  (contact)

PROJECT_TERMS: adverse event risk;African;African American population;African ancestry;All of Us Research Program;ancestry analysis;androgen deprivation therapy;Anti-Hypertensive Agents;Anticoagulants;APBA1 gene;APOL1 gene;arthropathies;Atrial Fibrillation;Benign;biobank;Bioinformatics;Biomedical Research;Black race;Blood Platelets;Blood Pressure;Body mass index;burden of illness;Cardiac;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cause of Death;Classification;Clinical;Clinical Pharmacology;Clinics and Hospitals;clopidogrel;Code;cohort;Communicable Diseases;Coronary;cost effective;COVID-19;CYP2C19 gene;Cystic Fibrosis;Data;data format;data integration;data modeling;Data Set;data standards;Diagnosis;Disease;disease diagnosis;disease phenotype;disorder risk;Disparity;drug discovery;drug repurposing;Effectiveness;Electronic Health Record;End stage renal failure;endometriosis;Environment;Ethnic Origin;Etiology;European;Evaluation;Event;Fibroid Tumor;follow-up;Gene Frequency;General Population;Genes;Genetic;genetic analysis;genetic architecture;genetic association;Genetic Diseases;Genetic Predisposition to Disease;Genetic Research;genetic variant;Genome;genome wide association study;Genotype;Goals;Graves' Disease;Guillain Barré Syndrome;health disparity;Heterozygote;high risk;Hispanic;Homozygote;Hypertension;Hypothyroidism;improved;Individual;individual variation;Investigation;Laboratories;Life Style;Link;loss of function;loss of function mutation;Malignant neoplasm of prostate;Manuals;Manuscripts;Maps;Mendelian randomization;Meniere's Disease;Meta-Analysis;Methods;Morbidity - disease rate;mortality;multimodality;Myocardial Infarction;Nature;Not Hispanic or Latino;novel;Paper;Participant;Pathogenicity;Patient Self-Report;Patients;Performance;personalized medicine;Pharmaceutical Preparations;Pharmacogenomics;phenome;Phenotype;phenotypic data;polygenic risk score;Population;Population Heterogeneity;Precision Health;precision medicine;Preparation;Prevalence;prevent;Procedures;programs;Provider;Publishing;Pulmonary Hypertension;Pythons;Race;Rare Diseases;rare variant;Recurrence;Regression Analysis;Report (document);Research;Resources;Respiratory Tract Infections;response;Risk;risk variant;Running;Sample Size;Seasons;Source;Surveys;Temporomandibular Joint Disorders;Test Result;Testing;Therapeutic;Time;Tissues;tool development;trait;translational study;trend;tumor;Uterine Fibroids;Uterus;Variant;variant of unknown significance;Viral Respiratory Tract Infection;Work

PROJECT_TITLE: Improving precision health approaches through large-scale EHRs and biobanks


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: NATIONAL LIBRARY OF MEDICINE

PI_NAMEs: KOONIN, EUGENE V (contact)

PROJECT_TERMS: adaptive immunity;Amino Acid Motifs;Amino Acid Sequence;Archaea;Architecture;Artificial Intelligence;ATP phosphohydrolase;Bacteria;Binding;Binding Proteins;Carrier Proteins;Case Study;Cell division;Censuses;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Complex;computational pipelines;Computing Methodologies;Custom;Cyclic Nucleotides;database structure;deep learning;Detection;Development;Dissection;Distant;DNA;Endosomes;Eukaryota;Eukaryotic Cell;Evolution;Genome;Genomics;Goals;Helix-Turn-Helix Motifs;Homologous Gene;Homologous Protein;Homology Modeling;Immune response;Infection;Investigation;Libraries;Life;markov model;Membrane;Messenger RNA;Methods;Methylation;Modeling;Molecular Chaperones;molecular sequence database;novel;nuclease;Pattern;Periodicity;Phylogenetic Analysis;Play;Positioning Attribute;Prokaryotic Cells;Protein Analysis;Protein Sequence Analysis;Protein Sortings;protein structure;protein structure prediction;Proteins;Resolution;response;Ribonucleases;Ribosomal RNA;RNA;RNA Binding;Running;scaffold;Sequence Analysis;SmpB protein;Sorting;Structural Models;Structure;System;Tertiary Protein Structure;Thermoproteales;Transfer RNA;Translations;Trees;Ubiquitin;viral DNA;Viral Genome;Viral Proteins;viral RNA;Virus;Winged Helix;Work

PROJECT_TITLE: Finding Protein Sequence Motifs--Methods And Applications


NIH_SPENDING_CATS: Genetics

PI_NAMEs: LANDSMAN, DAVID  (contact)

PROJECT_TERMS: Amino Acid Sequence;analytical tool;Binding;Binding Proteins;Binding Sites;Cell Nucleus;Chemicals;Chromatin;Chromatin Structure;Chromosome Structures;Classification;Competitive Binding;Complex;Consensus Sequence;crosslink;Data;Databases;Defect;DNA;driver mutation;Ensure;epigenetic regulation;Family;Genes;genetic regulatory protein;histone-binding proteins;Histones;HMGN Proteins;Human;Laws;Lead;Linker DNA;Location;Maintenance;Malignant Neoplasms;Maps;Measurement;Mediating;Modification;Molecular;Molecular Conformation;molecular recognition;Mutation;Non-Histone Chromosomal Proteins;Nuclear Proteins;Nucleosomes;Pathway interactions;Play;Post-Translational Protein Processing;Property;protein protein interaction;Proteins;public database;Radial;Regulation;Role;Running;Sequence Alignment;Signal Pathway;simulation;Structural Protein;Structure;Surface;Tail;Technology;Time;Transcription Regulatory Protein;Update;Variant

PROJECT_TITLE: Structural and Functional Analysis of Gene and Protein Sequence Families


PROJECT_TERMS: adaptive immunity;Affect;Affinity;Algorithms;Amoeba genus;anti-toxin;Archaea;Archaeal Genome;Archaeal Viruses;ATP phosphohydrolase;Bacteria;Bacterial Genome;Base Sequence;Biochemical;Biogenesis;Biological;biological systems;Biotechnology;Capsid;Capsid Proteins;Catalytic Domain;Cell Nucleus;Censuses;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;comparative;Computing Methodologies;Consensus Sequence;Coupled;Cysteine;Cytoplasm;Data;Data Set;Databases;DNA biosynthesis;DNA Packaging;DNA Transposable Elements;DNA-Directed DNA Polymerase;DNA-Directed RNA Polymerase;Dreams;ds-DNA;endonuclease;Engineering;Environment;Enzymes;Eukaryota;Evolution;Family;Family member;Gene Combinations;Genes;genetic regulatory protein;Genetic Transcription;Genome;genome editing;genome-wide;Genomics;Goals;Growth;Guide RNA;Guilt;Horizontal Gene Transfer;Immune system;in silico;inhibitor;insight;Laboratories;Life Cycle Stages;Link;Maps;mathematical methods;mathematical model;Medical;member;metagenome;Metagenomics;metatranscriptome;Methods;microbial;Mining;Modeling;molecular sequence database;N-terminal;Names;novel;novel virus;nuclease;Organism;Orthologous Gene;ovarian neoplasm;paralogous gene;Phylogenetic Analysis;Phylogeny;Plasmids;polypeptide;Probability;Process;professor;Prokaryotic Cells;promoter;protein structure;Proteins;recruit;Replication Initiation;Research;Rest;RNA;scaffold;Sequence Analysis;Specific qualifier value;System;Time;Toxin;Trees;trend;Validation;Variant;Viral;viral DNA;Virus;Virus Diseases;whole genome;Work

PROJECT_TITLE: Comparative Analysis Of Completely Sequenced Genomes


PROJECT_TERMS: Albumins;analysis pipeline;ATAC-seq;Binding;Binding Proteins;Bioinformatics;Cell Nucleus;cell type;Cells;ChIP-seq;Chromatin;cofactor;Collaborations;Data;DNA;DNA Binding;DNA Sequence;DNA-Binding Proteins;DNase I hypersensitive sites sequencing;Enhancers;Environment;Epigenetic Process;Exhibits;Family;GATA4 gene;Gene Expression Regulation;Genes;Genetic Recombination;Genetic Transcription;Genome;Genomics;Hepatocyte;HepG2;Higher Order Chromatin Structure;Histones;HMGN Proteins;Housekeeping Gene;interest;K562 Cells;Liver;Micrococcal nuclease digestion of chromatin followed by sequencing;Modeling;multidimensional data;National Cancer Institute;Non-Histone Chromosomal Proteins;Nucleic Acid Regulatory Sequences;Nucleosomes;Pattern;Play;Post-Translational Protein Processing;preference;promoter;Proteins;Role;Saccharomyces cerevisiae;Site;Specificity;Structure;transcription factor;Transcription Initiation;Transcriptional Regulation;transcriptome sequencing

PROJECT_TITLE: Gene Regulatory Sequences And Protein Binding in Genome Sequences


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza;Rural Health

PI_NAMEs: NELSON, MARTHA  (contact)

PROJECT_TERMS: 2019-nCoV;Agriculture;Animals;Back;Birds;Cattle;Chile;Circulation;Colorado;Dairying;Deer;Disease Outbreaks;Ecology;Emerging Communicable Diseases;emerging pathogen;Evolution;Farm;farm worker;Funding;Future;genomic data;Goals;High Prevalence;Human;Infectious disease threat;Influenza;Influenza A virus;Influenza A Virus, H5N1 Subtype;International;Knowledge;Length;Mammals;marine;Methodology;Michigan;Mink;Mirounga;Monitor;Mutation;next generation sequencing;Ohio;pandemic potential;pathogen;Pathogenicity;Pennsylvania;Peru;Polymerase Gene;pressure;Production;Research;Research Project Grants;Risk;RNA Viruses;Sampling;Sea Lions;South America;South American;Tail;Texas;Time;trend;United States National Institutes of Health;Variant;Viral Genome;Virus;wild bird

PROJECT_TITLE: Phylodynamics of emerging infectious disease threats


NIH_SPENDING_CATS: Genetics;Human Genome

PROJECT_TITLE: Genome Assemblies, Analyses, and Comparisons


ACTIVITY: ZIB

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza

PI_NAMEs: NAWROCKI, ERIC  (contact)

PROJECT_TERMS: 2019-nCoV;Algorithmic Software;Base Sequence;Biological;Biotechnology;Code;Computer software;cytochrome c oxidase;Databases;Dengue Virus;Detection;Genbank;Genes;Genome;Goals;improved;Influenza;Introns;Journals;Manuals;Modeling;Monkeypox;Norovirus;Paper;Performance;Proteins;Publications;Publishing;Quality Control;RNA Splicing;Sequence Analysis;Site;Software Tools;tool;Validation;Viral;Viral Genome

PROJECT_TITLE: Biological Sequence Quality Control and Organization


ACTIVITY: ZIC

NIH_SPENDING_CATS: Bioengineering;Genetics;Neurosciences

PI_NAMEs: WINKLER, DENNIS  (contact)

PROJECT_TERMS: 3-Dimensional;Achievement;Actins;Address;Amber;Auditory;Autophagocytosis;Autophagosome;Biological;Biophysics;Calendar;Calibration;Cells;Cellular biology;Cellular Structures;Chills;Cochlea;Collaborations;Communication;Computer software;Core Facility;Cryo-electron tomography;Cryoelectron Microscopy;Cultured Cells;Cytoskeleton;Data;data acquisition;Dedications;Development;Electron Microscope;Electron Microscopy;Endolymphatic Hydrops;Equipment;Event;experimental study;F-Actin;Freeze Substitution;Freezing;Genetic;Goals;Grant;Hair Cells;Human Resources;Humulus;Image;Immune;immunocytochemistry;Inner Hair Cells;instrument;instrumentation;interest;Intramural Research;Ion Channel;Ions;Journals;Kinesin;Kinocilium;Knockout Mice;Laboratories;Labyrinth;Lacrimal gland structure;Letters;Lipids;Liposomes;Manuscripts;Mediating;Methodology;Microscope;Microtubules;Molecular;Molecular Genetics;mouse model;Mus;mutant;Mutant Strains Mice;National Institute on Deafness and Other Communication Disorders;Nature;Negative Staining;new technology;Organ of Corti;Outer Hair Cells;Performance;Phase;Phenotype;Physiology;Plastic Embedding;Population;posters;Preparation;preservation;pressure;Presynaptic Terminals;programs;Proteins;Publications;Recommendation;reconstruction;Research;Research Personnel;Research Support;Resources;restoration;ribbon synapse;Sampling;Scanning;Scanning Electron Microscopy;Scientist;Sensory;Sensory Physiology;Series;Services;Site;Specialist;Specimen;Structure;Synaptic Vesicles;System;Techniques;Tissues;Titan;tomography;Training;Transducers;Transmission Electron Microscopy;transmission process;United States National Institutes of Health;Visualization;Water;Wild Type Mouse;Work;Writing;Zebrafish

PROJECT_TITLE: Advanced Imaging Core


PROJECT_TERMS: Bioinformatics;Cells;Computational Biology;Computer Analysis;Data;Data Analyses;Databases;Deposition;design;Epigenetic Process;exome;Experimental Designs;experimental study;genomic data;Genomics;Infrastructure;Intramural Research;Labyrinth;Libraries;Mission;Molecular Biology;National Institute of Dental and Craniofacial Research;National Institute on Deafness and Other Communication Disorders;Principal Investigator;Production;public repository;Reagent;Research Personnel;Tissues;Training;transcriptome sequencing;variant detection;whole genome;Work

PROJECT_TITLE: Genomic and Computational Biology Support for NIDCD Intramural Research