ADMINISTERING_IC: DE

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Newark

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF DELAWARE

PHR: Project Narrative This project seeks to develop an alternative treatment method for xerostomia or dry mouth, a devastating side effect of radiation therapy that affects 68-85% of head and neck cancer patients. We will develop a bottom-up approach to recreate a functional salivary gland using patient-derived cells with regenerative potential and artificial extracellular matrices that recapitulate the native microenvironments of the developing organ. The goal is to produce an engineered construct with branched architecture consisting of secretory acini and connected ducts.

PI_NAMEs: JIA, XINQIAO  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: 3-Dimensional;Ablation;Acinar Cell;Acinus organ component;Affect;Alkenes;alternative treatment;analog;Animal Model;Architecture;Basement membrane;Beds;Biochemical;biochip;Biological Markers;biomaterial compatibility;Biomechanics;Blood Vessels;Body Weight decreased;Carbachol;career networking;Cell Communication;Cell Differentiation process;Cell Lineage;Cell Polarity;Cells;Cellular Spheroids;Chemicals;Coculture Techniques;Communication;Communities;Complex;Cues;cycloaddition;Deglutition;Dental;Development;Development Plans;Dimensions;Doctor of Philosophy;Duct (organ) structure;Ductal Epithelial Cell;Eating;Encapsulated;Endothelial Cells;Endothelium;Engineering;Environment;Epithelial Cells;Epithelium;Exhibits;Extracellular Matrix;Foundations;Funding;Future;Gel;Gene Expression Profile;Gland;Goals;graduate student;Growth;Growth Factor;Head and Neck Cancer;head and neck cancer patient;Health;Heterogeneity;Homeostasis;Human;Human Engineering;Hydrogels;Immunocompetent;Implant;implantation;In Vitro;in vivo;Individual;innovation;interfacial;interstitial;Intraperitoneal Injections;Investigation;Ligation;low socioeconomic status;Maintenance;Measures;Mediating;meetings;Mentors;Mesenchymal;Mesenchymal Stem Cells;Methods;Microfluidics;microphysiology system;mimetics;Morphogenesis;morphogens;Morphology;Motility;Natural regeneration;Nerve;Neurons;Neurotransmitters;neurotrophic factor;neurturin;Nude Rats;Oral;Oral cavity;Organ;Outcome Measure;parent grant;parent project;Parotid Gland;Patients;Pattern;Peptide Hydrolases;Peptides;Phenotype;Pilocarpine;polarized cell;progenitor;programs;Property;Proteomics;Radiation therapy;Rattus;Reaction;reconstitution;recruit;regeneration potential;Research;Resected;response;restoration;Saliva;Salivary duct structure;Salivary Gland Tissue;Salivary Glands;Scientist;Sepharose;side effect;Signal Transduction;skills;spheroids;stem;stem cell biomarkers;stem cell expansion;stem cells;Structure;subcutaneous;Symptoms;Time;Tissue Engineering;Tissue Expansion;Tissue Model;Tissues;Training and Education;transcriptome;transcriptome sequencing;transplant model;Treatment Efficacy;Trees;vascular factor;Vascularization;Work;Xerostomia

PROJECT_TITLE: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp)

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Rockville

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

ORG_STATE: MD

PHR: DNA forms a variety of non-canonical structures that are important for the proper regulation of molecular processes such as replication, recombination, and transcription, but these structures can also promote mutagenesis, driving disease states. This conference will focus on the mechanisms by which DNA structures form, mutate, and resolve, with emphasis on new technologies that can analyze the effects of cellular and environmental factors on different DNA structures. In addition, the conference will provide a supportive and interdisciplinary environment in which new investigators and trainees can interact with field leaders to share their findings and develop collaborations, leading to new therapeutic approaches.

PI_NAMEs: MCVEY, MITCH  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Automobile Driving;Biology;biophysical analysis;career;career development;Cell Physiology;Chromosomes;Collaborations;collaborative environment;Data;Development;developmental disease;Disease;DNA;DNA biosynthesis;DNA Sequence;DNA Structure;DNA Transposable Elements;Environmental Risk Factor;Etiology;Feedback;Florida;Funding;G-Quartets;Generations;Genetic Recombination;Genetic Transcription;Genomic Instability;Genomics;Goals;Hereditary Disease;Human;human disease;Individual;Industry;Inherited;insight;Malignant Neoplasms;Molecular;Mutagenesis;Mutate;Mutation;Nervous System Disorder;new technology;novel therapeutic intervention;nuclease;Parasites;Participant;Pathologic;posters;preference;Process;programs;Property;recruit;Regulation;repaired;Repetitive Sequence;Request for Proposals;Research;Research Personnel;Resolution;response;Role;Science;Scientist;single molecule;Single-Stranded DNA;Structure;summer research;supportive environment;symposium;Tandem Repeat Sequences;Technology;Telomere Maintenance;Therapeutic;Time;transcription termination;translational approach;Trinucleotide Repeats;Virus

PROJECT_TITLE: Dynamic DNA Structures in Biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 BWD-W (R3)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE We propose a 2024 conference for brain tumor epidemiologists and clinicians that will focus on survivorship issues for brain tumor patients. This conference will facilitate collaborative interactions among epidemiologists and clinicians, support development of trainees, and provide educational opportunities for all attendees.

PI_NAMEs: OSTROM, QUINN T (contact)

PROGRAM_OFFICER_NAME: BURNETT, ANDREA NICOLE

PROJECT_TERMS: Address;Adolescent and Young Adult;Adult;Advocate;Affect;Age;American;Benign;Brain Neoplasms;Cancer Etiology;career development;Central Nervous System Neoplasms;Cessation of life;Child;Childhood;Clinical Oncology;Collaborations;Communication;Communities;Continuance of life;Data;Dedications;Development;Diagnosis;Diffuse intrinsic pontine glioma;Discipline;Education;Environment;Epidemiologist;Epidemiology;Etiology;experience;field study;Fostering;Foundations;Funding;Germany;Glioblastoma;Glioma;Goals;Immunotherapy;improved;Individual;innovation;interest;International;Long-Term Survivors;low and middle-income countries;Malignant - descriptor;Malignant Neoplasms;Medicine;Medulloblastoma;meetings;Mentors;Mentorship;Morbidity - disease rate;mortality;multidisciplinary;mutant;neuro-oncology;neurosurgery;Non-Malignant;novel;novel therapeutics;Outcome;Participant;Pathology;patient population;Patients;Persons;Population;Primary Brain Neoplasms;Psychology;Quality of life;Research;Research Activity;Research Personnel;Risk;Self Care;Site;Source;survival outcome;Survivors;survivorship;symposium;targeted treatment;Technology;Time;tumor;Tumor Burden;Underrepresented Minority;United States;United States National Institutes of Health;working group

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (J1)]


ADMINISTERING_IC: AI

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: Princeton

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative Hepatitis B virus (HBV) causes chronic infections in over 250 million patients worldwide who risk developing severe liver disease, including liver cancer. The development of curative therapies has been significantly hampered by the lack of small animal models that support HBV infection and recapitulate disease. Building on exciting new data from our lab, we aim to investigate why HBV does not infect other species, in particular mice, with the goal of creating a mouse model for HBV infection.

PI_NAMEs: IJOMA, JENNY NNEKA (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Academia;Address;Agreement;alpha Karyopherins;Animal Model;Binding;Biomedical Research;Capsid;career;Cell Nucleus;Cells;Cessation of life;Chimera organism;Chronic;Chronic Hepatitis B;chronic infection;Circular DNA;Complex;confocal imaging;Confocal Microscopy;Contracts;Core Protein;Credentialing;curative treatments;Data;Dedications;Dependence;Development;Disease;end stage liver disease;experience;experimental study;gain of function;Goals;Hepatic;Hepatitis B Infection;Hepatitis B Vaccines;Hepatitis B Virus;Hepatitis Viruses;Hepatocyte;hepatoma cell;heterokaryon;Human;Importins;improved;Individual;Industry;Infection;Inherited;insight;Karyopherins;Lead;Life Cycle Stages;Liver Cirrhosis;Liver diseases;Malignant neoplasm of liver;Maps;Medical;Mentors;Molecular Virology;mouse model;Mus;Mutation;Na(+)-taurocholate-cotransporting peptide;Nuclear Import;Nucleocapsid;Pan Genus;Pathogenesis;pathogenic virus;Patients;permissiveness;Persons;Pongidae;Population;Predisposition;Preventive vaccine;Primary carcinoma of the liver cells;Process;protein expression;Protein Import;protein purification;Proteins;Relaxation;Resistance;Rest;Risk;Role;Techniques;Testing;therapy development;Transfection;Transmission Electron Microscopy;Tropism;uptake;Vaccinated;Viral;Viral Genome;Viral Pathogenesis;Virion;Virus;Virus Diseases;Virus Receptors;Visualization;Work

PROJECT_TITLE: Delineating the impact of human karyopherins on hepatitis B virus species tropism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BALTIMORE

ORG_DEPT: GENETICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Mitochondria play a key role in sudden cardiac arrest (SCA) risk and recovery. We will leverage data from a total of ~5000 SCA cases to identify, validate, and functionally characterize mitochondrial genetic variants associated with SCA risk and resuscitation outcomes. These investigations ultimately will lead to innovative approaches to prevent SCA and improve resuscitation outcomes.

PI_NAMEs: ARKING, DAN E (contact);REA, THOMAS D;SOTOODEHNIA, NONA

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Accounting;Address;Alleles;Apoptosis;Arrhythmia;Autopsy;base editing;Biochemical;Biocompatible Materials;Brain;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;Cardiopulmonary Resuscitation;Case/Control Studies;Cell Respiration;Cells;Cessation of life;Characteristics;Circulation;Clinical;clinical material;Cohort Studies;Communities;Complement;computerized tools;Coronary Arteriosclerosis;Data;Deaminase;density;Development;Discipline;DNA copy number;Dose;Electrophysiology (science);Etiology;Functional disorder;Genetic;genetic association;genetic variant;Genetic Variation;Genome;Haplotypes;Heart;Heart Arrest;heart electrical activity;heteroplasmy;high risk;Human;human induced pluripotent stem cells;Hydrogen Peroxide;improved;Inherited;Injury;innovation;Investigation;Leigh Disease;Link;Mitochondria;Mitochondrial DNA;mitochondrial genome;model organism;modifiable risk;mortality;multidisciplinary;mutant;Myocardial Ischemia;National Heart, Lung, and Blood Institute;Neurological status;novel;Outcome;Oxidative Stress;Pathologic;Phenotype;Play;Population;population based;prevent;Prevention;prospective;Prospective cohort;Public Health;Rare Diseases;rare variant;Recovery;Reperfusion Injury;response;restoration;Resuscitation;Risk;Risk Factors;Role;Series;Somatic Mutation;Superoxides;Surveys;Survivors;Technology;Testing;therapeutic target;Trans-Omics for Precision Medicine;Variant;Ventricular Fibrillation;Work

PROJECT_TITLE: Human Mitochondrial Variation and Sudden Cardiac Arrest Risk and Resuscitation

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: NARRATIVE This study will examine the function of a population of spinal deep dorsal inhibitory interneurons that inhibit locomotor circuit interneurons, and the plasticity of afferent pathways to this population after spinal cord injury. The findings from this proposal will reveal potential neurons and pathways to serve as therapeutic targets for the restoration of locomotion after spinal cord injury.

PI_NAMEs: MCGRATH, JENNA  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Acute;Adult;Affect;Afferent Pathways;Behavior;Cells;Cervical;Chest;Cholera Toxin;Chronic;combinatorial;Data;designer receptors exclusively activated by designer drugs;Dorsal;dorsal horn;Electrophysiology (science);experimental study;Feedback;Future;Goals;Hindlimb;Histology;Immunohistochemistry;improved;inhibitory neuron;Injections;Injury;insight;interest;Interneurons;Joints;Knowledge;Lesion;Locomotion;locomotor control;Locomotor Recovery;locomotor tasks;Maintenance;Medial;Modeling;Molecular;Motor;Motor output;Movement;Mus;Muscle;neural;Neurons;new therapeutic target;novel;patch clamp;Pathway interactions;Pattern;Pharmacology;placebo group;Population;prevent;Prevention;Property;Proprioception;Rehabilitation therapy;restoration;Role;Sensory;sensory input;skills;Slice;Spinal;Spinal Cord;Spinal cord injury;Spinal cord posterior horn;Spinal Cord transection injury;spinal nerve posterior root;Structure;Subgroup;Synapses;targeted treatment;Testing;therapeutic target;transcription factor;transmission process;Work

PROJECT_TITLE: Medial deep dorsal glycinergic interneurons as a target for improving locomotion following spinal cord injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


ORG_CITY: COLLEGE STATION

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Mitochondrial diseases are a group of clinically variable disorders caused by the malfunction of cellular components called mitochondria, which are responsible for generating energy that powers vital body processes. This proposal will utilize cell and animal models to investigate why patients with with mitochondrial disease are more susceptible to lung injury and inflammation after infection with opportunistic bacterial pathogens. This research will have a positive impact on public health because it will enhance our understanding of immune dysfunction in mitochondrial disease and may lead to innovative treatments that alleviate inflammatory and infectious pathology in patients with these disorders.

PI_NAMEs: VAN PORTFLIET, JORDYN  (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acute Lung Injury;Animal Model;Animals;Anti-Bacterial Agents;Anti-Inflammatory Agents;Antioxidants;Binding Proteins;Biological Assay;Caspase;Cell Death;Cell model;Cells;Clinical;cytokine;Defect;Detection;Development;Disease;DNA Maintenance;Environmental Exposure;Enzyme-Linked Immunosorbent Assay;Erythroid;Exhibits;experimental study;Exposure to;Failure;FDA approved;Fumarates;Functional disorder;gene function;gene repression;Genes;guanylate;Immune;Immune signaling;Immune System Diseases;Immunofluorescence Microscopy;immunopathology;Impairment;In Vitro;in vivo;in vivo Model;Infection;Infiltration;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;innovation;Interferon Type I;intraperitoneal;Knowledge;Lipopolysaccharides;Lung;lung injury;Macrophage;Metabolic;microbial;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;Modeling;Morbidity - disease rate;mortality;mouse model;mutant;Mutant Strains Mice;Mutation;Myelogenous;Myeloid Cells;Natural Immunity;Neutrophil Infiltration;novel;Nuclear;nuclear factor-erythroid 2;Opportunistic Infections;Oxidative Phosphorylation;pathogenic bacteria;Pathogenicity;Pathology;Pathway interactions;Patients;Permeability;Phagolysosome;Pharmaceutical Preparations;Polymerase;Predisposition;Process;Production;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Public Health;Pulmonary Inflammation;Pulmonary Pathology;recurrent infection;Research;Respiratory Chain;respiratory pathogen;Respiratory Tract Infections;Sepsis;Serum;Signal Transduction;Testing;Western Blotting

PROJECT_TITLE: Targeting the Nrf2 axis to reduce lung immunopathology in PolG-related mitochondrial disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE  Outgrowth of a large variety of pathogenic bacteria contributes to the progression of periodontal disease. The proposed research will provide insight into how an otherwise unstudied pathogen, Selenomonas sputigena, invades into the cells of the gingival tissue where the organism then disrupts host biology. This research is among the first ever investigations into how this organism interacts with the host and will help elucidate the collective knowledge of how bacteria in the complex plaque biofilm cause periodontal disease.

PI_NAMEs: HAWKES, COLIN G (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: 3-Dimensional;Actins;Antibiotics;Attenuated;Bacteria;bacterial community;Basal Cell;Binding;Biochemical;Biogenesis;Biological Assay;Biology;Cells;Characteristics;Chemotaxis;Chronic;Clathrin;Communities;Complex;Cytoskeleton;Data;Data Reporting;dental biofilm;Disease;DNA;Dyes;Early Endosome;Early identification;Encapsulated;Endocytosis;Endosomes;Epithelial Cells;Epithelium;Etiology;Exocytosis;exosome;experimental study;Fluorescence Microscopy;Fluorescent Antibody Technique;Foundations;Gingiva;Hour;Immune;Immunofluorescence Microscopy;Immunologic Stimulation;Infection;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;insight;Invaded;Investigation;keratinocyte;Knowledge;late endosome;Life Cycle Stages;Mediating;member;Microscopic;Modeling;Molecular;monocyte;Multivesicular Body;neutrophil;new therapeutic target;Nuclear Envelope;Organism;pathobiont;pathogen;pathogenic bacteria;Pathway interactions;Periodontal Diseases;periodontopathogen;pharmacologic;Porphyromonas gingivalis;Process;Production;Proliferating;Proteins;Publishing;recruit;Reporter;Reporting;Research;Selenomonas sputigena;Testing;Time;Tissue Model;Tissues;Toxic effect;trafficking;Transmission Electron Microscopy;Vesicle;Work

PROJECT_TITLE: Characterization of Selenomonas sputigena invasion, intracellular life cycle, and exocytosis in gingival epithelial cells.

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Women's Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Major depressive disorder (MDD) disproportionately affects women, but the biological basis of this sex difference is not understood, and stress vulnerability is emerging as a critical risk factor of MDD. Studies have implicated the ventral hippocampal (vHPC) projections to the nucleus accumbens (NAc; vHPC-NAc) in stress-induced susceptibility, and this circuit excitability is reduced by adult testosterone in mice. This research plan will investigate the role of androgen receptors, the signaling pathways involved, and the molecular mechanisms underlying vHPC-NAc circuit excitability which will elucidate how adult testosterone regulates vHPC-NAc circuit function to drive sex-specific behaviors and vulnerability to stress and may lead to specific novel pharmacological therapeutic targets that could be used to treat female patients for MDD.

PI_NAMEs: SUGIMOTO, CHIHO  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Adult;Androgen Receptor;androgen sensitive;Anhedonia;Automobile Driving;Behavior;Binding;Biological;brain abnormalities;career;Cell Nucleus;Cells;Complex;conditional knockout;Cytosol;Data;Depressive disorder;Development;disability;Disproportionately impacts women;DNA;DNA Binding;Electrophysiology (science);Etiology;experimental study;Female;Gene Expression;Gene Targeting;Genes;Goals;High Prevalence;Hippocampus;Investigation;Ion Channel;Knock-out;Knowledge;Major Depressive Disorder;male;Mediating;Membrane;men;Mental disorders;Molecular;Motivation;mouse model;Mus;neuronal excitability;Neurons;Neuropharmacology;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Nucleus Accumbens;Operative Surgical Procedures;Orchiectomy;Patients;pharmacologic;Pharmacology;Phenotype;Positioning Attribute;Postdoctoral Fellow;Potassium Channel;Predisposition;Receptor Activation;Receptor Signaling;Regulation;Research;Research Personnel;resilience;reward circuitry;Risk Factors;Role;sex;sex development disorder;Sex Differences;Signal Pathway;Signal Transduction;Slice;Stimulus;Stream;Stress;Testing;Testosterone;Therapeutic Intervention;therapeutic target;Time;tool;Training;Viral Vector;Wild Type Mouse;women patients;women subjects;Women's prevalence;Women's study;women's treatment

PROJECT_TITLE: Circuit-specific androgen receptor regulation of hippocampal neuronal excitability

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE TH17 cells play a pivotal role in inflammatory bowel disease (IBD) pathogenesis through secretion of many pro- inflammatory cytokines and chemokines. The nuclear receptor NR2F6 is reported to act as a negative transcriptional regulator of TH17 cells making its agonism a promising target for IBD therapy. The proposed studies will address fundamental questions regarding the transcriptional role of NR2F6, insights which will be particularly valuable understanding TH17-mediated chronic inflammation and whether targeting this nuclear receptor may be therapeutically relevant.

PI_NAMEs: WILSON, ADRIANNA NICOLE (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Affect;ATAC-seq;Autoimmune;Autoimmunity;Automobile Driving;Binding;Biology;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Physiology;Cell secretion;Cells;Cellular biology;chemokine;Chromatin;chromatin remodeling;Chronic;chronic inflammatory disease;Cleavage Under Targets and Release Using Nuclease;Clinical;Co-Immunoprecipitations;cofactor;Colitis;Crohn's disease;cytokine;Data;Development;Disease;Effector Cell;effector T cell;Experimental Genetics;extracellular;Flow Cytometry;fungus;Gastrointestinal tract structure;gene repression;Genes;Genetic study;Genetic Transcription;Genome;genome wide association study;Genomic approach;genomic locus;Goals;high throughput screening;IL17 gene;Immune response;Immunomodulators;In Vitro;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;insight;interleukin-21;interleukin-22;interleukin-23;Intrinsic factor;Knock-out;Knockout Mice;Ligand Binding;Ligands;Literature;LoxP-flanked allele;Mediating;Modeling;Molecular;Molecular Biology;Molecular Mechanisms of Action;Multiomic Data;Mus;neutralizing antibody;NR2F6 gene;Nuclear Orphan Receptor;Nuclear Receptors;orphan nuclear receptor ROR-gamma;overexpression;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Play;Production;Proteomics;Publishing;recruit;Reporting;Research;response;Role;small molecule;Structure-Activity Relationship;success;T-Lymphocyte;targeted treatment;Therapeutic;therapeutically effective;Time;Tissues;TNF gene;transcription factor;Transcriptional Regulation;transcriptome sequencing;treatment effect;Ulcerative Colitis

PROJECT_TITLE: Defining the Transcriptional Activity of NR2F6 in TH17 cells

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE Chronic kidney disease of unknown etiology (CKDu) is a global public health crisis with high morbidity and mortality in Central America, and Nicaraguan youth in regions with high adult CKDu prevalence have shown evidence of kidney injury. Nephrotoxic metals have been associated with CKDu in adults and are arguably more toxic to youth given ongoing development of organ systems, though no prior studies have assessed environmental exposures in this high-risk group of young people. While changes in the human microbiome have been associated with both metal exposure and renal health in other populations, we propose the first study to consider metal exposure, the urinary microbiome, and renal function in Central American youth, results of which may inform early CKDu detection and intervention efforts.

PI_NAMEs: HALL, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: 16S ribosomal RNA sequencing;18 year old;Adolescence;Adolescent;Adult;Affect;Age;Agricultural Workers;Agrochemicals;analytical method;Arsenic;Biological;Biological Markers;Biometry;Body System;Cadmium;Central America;Central American;Characteristics;Childhood;Chronic Kidney Failure;cohort;Communities;Data;Dedications;Detection;Development;Developmental Process;Disease;Disease Marker;Disease Pathway;Disease Progression;dysbiosis;early life exposure;Enrollment;Environmental Epidemiology;Environmental Exposure;Etiology;Exposure to;extreme heat;flexibility;Fluorescence;follow-up;Glomerular Filtration Rate;Health;Health Status;Health Surveys;Heavy Metals;high dimensionality;high risk;high risk population;Human Microbiome;human microbiota;indexing;Individual;Industrialization;Injury to Kidney;interest;Intervention;Joints;Kidney;Kidney Diseases;Lead;Life;Life Cycle Stages;Linear Models;Linear Regressions;Literature;Longitudinal cohort;Machine Learning;male;Measures;Mentorship;Mercury;Metal exposure;Metals;Methods;microbial;microbiome;microbiome analysis;Modeling;Morbidity - disease rate;mortality;nephrotoxicity;network models;Nicaragua;Nicaraguan;novel;Occupational;Occupational Exposure;Onset of illness;Organ;organ growth;Outcome;Participant;Persons;Population;portability;predictive modeling;Prevalence;Principal Component Analysis;Process;Public Health;renal damage;Renal function;Research;Research Activity;Risk;Risk Factors;Roentgen Rays;Role;Saccharum;Sampling;sex;skills;Staphylococcaceae;Structure of nail of toe;System;Techniques;Training;urinary;Urinary Microbiome;Urine;Work;Youth

PROJECT_TITLE: Metals, the Microbiome, and Kidney Health Among Adolescents in Central America

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative The 2024 Gordon Research Conference on Bioinspired Materials will be held June 16-21, 2024 in Les Diablerets, Switzerland, and will be preceded by an accompanying Gordon Research Seminar (June 15-16, 2024). The program focuses on current, cutting-edge advances in the area of bioinspired materials, with a specific emphasis on the delivery of therapeutics, tissue engineering, and living materials. As a GRC conference, the meeting will emphasize unpublished work, provide a setting for personal scientific exchanges, and accommodate a diverse group of speakers and attendees.

PI_NAMEs: DEFOREST, COLE A (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: analog;Area;Attention;Biocompatible Materials;Biological;Biological Process;Budgets;Cells;cellular targeting;Communities;community building;Complex;Data;design;Development;Discipline;diversity and inclusion;Drug Delivery Systems;Educational Status;Elements;Engineering;Environment;experience;Exposure to;Fertilization;Future;Goals;graduate student;Health;Hour;Human;Immunotherapy;interest;International;materials science;Mechanics;meetings;member;Minority Groups;National Institute of Biomedical Imaging and Bioengineering;novel;Oral;Polymers;Postdoctoral Fellow;posters;Process;programs;Research;Research Personnel;scaffold;Scientist;self assembly;social;Students;Switzerland;symposium;System;Therapeutic;Tissue Engineering;Tissues;Travel;Underrepresented Minority;United States National Institutes of Health;unpublished works;Vaccines;virtual;virucide;Woman;Work

PROJECT_TITLE: 2024 Bioinspired Materials Gordon Research Conference and Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-F (J1)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative: Obesity in the United States has become a grave public health threat, highlighting the need for the development of more effective obesity treatments. Understanding how gastrointestinal-derived satiation signals, such as amylin, affect neuronal activity to control feeding behavior is necessary for the development of novel pharmacotherapies to combat obesity. The proposed work will evaluate the role of amylin receptor signaling in a novel mesopontine-limbic pathway in the regulation of food intake and motivation to seek palatable food rewards.

PI_NAMEs: SANCHEZ-NAVARRO, MARCOS J (contact)

PROJECT_TERMS: Adult;Affect;amylin receptor;analog;Anatomy;Animal Feed;Animals;Appetite Depressants;Behavior;Binding;Biological Assay;Body Weight;Body Weight Changes;Calcitonin;Calcitonin Receptor;Cardiovascular Diseases;Cell Nucleus;combat;comorbidity;Data;designer receptors exclusively activated by designer drugs;Development;diabetes risk;Diet;diet-induced obesity;Dopamine;dopaminergic neuron;Eating;energy balance;Energy consumption;Energy Intake;experimental study;feeding;Feeding behaviors;Female;Fiber;Food;Food Intake Regulation;Gastric Emptying;gastrointestinal;Genetic;Heterodimerization;High Fat Diet;hindbrain;Hormones;Human;Hypothalamic structure;Immunohistochemistry;Impaired cognition;Impairment;Impulsivity;in vivo;Intake;islet amyloid polypeptide;knock-down;Knowledge;Malaise;male;Mediating;Metabolic;Monitor;motivated behavior;Motivation;Nature;Neurons;Neurosecretory Systems;novel;Nutrient;Obesity;obesity treatment;Overweight;Pathway interactions;Pattern;Pharmacotherapy;Photometry;Physiological;Proteins;Public Health;RAMP1;Rattus;receptor;Receptor Signaling;reduced food intake;Regulation;Research;response;Rewards;Rodent;Role;Salmon;Satiation;Signal Pathway;Signal Transduction;Structure;Symptoms;Synaptic Transmission;System;Testing;Thinness;United States;Ventral Tegmental Area;Viral;Viral Vector;Weight Gain;western diet;Work

PROJECT_TITLE: The role of LDTg to VTA calcitonin receptor signaling in the control of food reward

STUDY_SECTION_NAME: Fellowships in Diabetes Endocrinology and Metabolic Diseases [DDK-E]


NIH_SPENDING_CATS: Genetics;Hematology;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE My research will elucidate molecular mechanisms by which GATA2 deficiency elevates innate immune signaling in fetal progenitor cells and determine the resulting functional consequences. My studies with cultured cells and an innovative mouse model utilize multidisciplinary approaches to test hypotheses that will advance and potentially transform the paradigm linking GATA2 to innate immune signaling, which has important implications for hematologic pathologies.

PI_NAMEs: TRAN, VU LE-HUY (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: Ablation;active control;Acute Myelocytic Leukemia;Address;Adult;Agonist;B-Lymphocytes;Behavior;Biological Assay;Biological Process;bone marrow failure syndrome;Cell Lineage;Cell Separation;Cells;chemokine;Chromatin;Code;Critical Thinking;Cultured Cells;cytokine;Data;Defect;derepression;Distal;Dysmyelopoietic Syndromes;Embryo;Enhancers;Erythroid;Exhibits;Fetal Liver;fetal stem cell;Fostering;GATA2 deficiency;gene editing technology;Gene Expression;Gene Expression Regulation;Gene Proteins;Generations;Genes;Genetic;Genetic Transcription;genome-wide;granulocyte;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Immune;Immune signaling;immunodeficiency;Impairment;Inherited;innovation;interdisciplinary approach;Interferon Type II;Interleukin-6;Link;Lymphoid;Mediating;Mentorship;Mitogen-Activated Protein Kinases;Modeling;Molecular;monocyte;mouse model;Mus;Mutation;Myelogenous;Myeloid Cells;Pathology;Pathway interactions;Phase;Positioning Attribute;Production;progenitor;promoter;proto-oncogene protein Spi-1;Quantitative Reverse Transcriptase PCR;Receptor Signaling;Regulatory Element;Research;response;Scientist;Signal Pathway;Signal Transduction;Site;stem cell differentiation;stem cell function;stem cells;Syndrome;Testing;TLR1 gene;TLR2 gene;Toll-Like Receptor Pathway;Toll-like receptors;Training;transcription factor;Transcription Factor AP-1;Transcription Initiation Site;transcriptome sequencing;Transplantation;Untranslated RNA

PROJECT_TITLE: Linking GATA2 deficiency to innate immune signaling

STUDY_SECTION_NAME: Fellowships in Kidney, Urology, and Hematology[DDK-G]


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative: Proper T cell signaling is required for effective immunity, while aberrant T cell activation is associated with autoimmunity, immunodeficiency, and increased susceptibility to infections and cancer. Our lab has observed that membrane proximal T cell signaling involves physical and functional coupling between membrane domains and protein condensates. The proposed project studies the mutual regulation between membrane rafts and protein condensates in vitro and in live cells and how they affect T cell signaling to advance understanding of spatiotemporal regulation of signal transduction in activated T cells.

PI_NAMEs: CHAN, SZE HAM  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immunity;Adaptor Signaling Protein;Affect;Agonist;Attention;Autoimmune Diseases;Autoimmunity;Biochemical;biophysical properties;Biophysics;Biosensor;Cell membrane;Cell Nucleus;cell type;Cells;Cellular Membrane;Cholesterol;Coupled;Coupling;cytokine;Cytoplasm;Cytosol;Data;density;Dietary Fats;engineered T cells;Environment;experimental study;Fluorescence;fluorescence lifetime imaging;Genetic;Goals;Growth Factor Receptors;Immune;Immune response;Immunity;immunodeficiency;Immunologic Deficiency Syndromes;immunological synapse;Immunotherapy;improved;In Vitro;Infection;insight;Intake;Jurkat Cells;Lateral;Ligation;Link;lipidomics;Lipids;Liquid substance;Malignant Neoplasms;Measures;Mediating;Membrane;membrane assembly;Membrane Lipids;Membrane Microdomains;membrane model;membrane reconstitution;Microscopy;Monitor;novel therapeutic intervention;Nucleoplasm;Organism;Peptide/MHC Complex;pharmacologic;Phase;Phosphorylation;Physical condensation;physical property;Predisposition;Production;Proliferating;Property;Proteins;receptor binding;reconstitution;recruit;Regulation;Reporter;Reporting;Research;response;Role;Scaffolding Protein;sensor;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;Site;Son;spatiotemporal;Stimulus;Supplementation;System;T cell regulation;T-Cell Activation;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Techniques;Temperature;temporal measurement;Testing;Time;Total Internal Reflection Fluorescent;Variant;Work

PROJECT_TITLE: Mutual regulation between membrane rafts and protein condensates in T cell activation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biotechnology;Neurosciences

ORG_CITY: CORAL GABLES

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

PHR: Project Narrative- Stephanie Dancausse Neurotransmitters, like dopamine, play essential roles in carrying out appropriate behaviors in response to an organism’s environment. In order to understand how dopamine in the central brain functions as a neuromodulator and the subsequent impact on locomotive behavior, one must identify the sensitive neurons and their role in behavioral output. Utilizing an invertebrate model to elucidate neural pathways that underlie locomotion and motor control can be yield applicable information in higher order organisms to comprehend disease states associated with these behaviors.

PI_NAMEs: DANCAUSSE RODRIGUEZ, STEPHANIE MARIE (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Adult;Aggressive behavior;Behavior;Behavioral;Behavioral Assay;behavioral response;Biological Models;Brain;Brain region;Calcium;calcium indicator;Cells;Central Nervous System;Characteristics;cholinergic neuron;Complex;Confocal Microscopy;Data;Disease;Dissection;Dopamine;Dopamine Receptor;dopaminergic neuron;Drosophila genus;Drosophila melanogaster;Embryo;Environment;experience;experimental study;Exploratory Behavior;Fluorescent Probes;fly;Frequencies;Gene Expression;Genes;Genetic;genetic manipulation;Hour;Human;Hyperactivity;Image;in vivo;Invertebrates;Larva;larval control;Learning;Life;Life Cycle Stages;Locomotion;locomotor control;Mammals;Mediating;Memory;Methods;Modeling;Motion;motor control;Motor output;Movement;Mushroom Bodies;Nervous System;neural;neural circuit;Neural Pathways;neuromechanism;Neuromodulator;Neurons;neuroregulation;Neurotransmitters;novel;novel strategies;Organism;Output;Pathway interactions;Peripheral Nervous System;pharmacologic;Play;prospective;receptor;response;robotic system;Robotics;Role;Second Messenger Systems;Sensory;Signal Pathway;Signal Transduction;Speed;Stereotyped Behavior;System;Time;tool;transmission process

PROJECT_TITLE: The neuromodulatory role of dopamine signaling on locomotion of Drosophila Larvae


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Deciphering the cryptic patterns of protein recognition sites within cis-regulatory elements along DNA is fundamental to understanding the transcriptional regulation of genes. Deep neural networks applied to this task have demonstrated impressive performance; however, because of their complex nature, it remains difficult to determine how these networks form their decisions. This project will develop a new surrogate modeling framework for interpreting the cis-regulatory syntax learned by deep neural networks, providing a software suite of computational tools for the biomedical community that will have direct applications for understanding complex biological systems and treatment of human disease.

PI_NAMEs: SEITZ, EVAN ELLIOTT (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Address;Area;Benchmarking;Binding Proteins;Biological;Biological Assay;Biological Response Modifier Therapy;Biological Sciences;Black Box;career development;Communities;Complex;complex biological systems;computational suite;Computer software;computerized tools;Computing Methodologies;Cryoelectron Microscopy;Data;Data Set;deep learning;deep neural network;design;Development;direct application;DNA;Educational workshop;Effectiveness;Entropy;Environment;Equilibrium;Essential Genes;experience;experimental study;Exposure to;Foundations;functional genomics;Future;Gene Expression;Gene Expression Regulation;generative models;genomic data;genomic predictors;Genomics;Goals;human disease;improved;in silico;insight;interest;Joints;Laboratories;Learning;lens;Libraries;machine learning method;mathematical model;Mathematics;Measures;meetings;Mentorship;Methods;Modeling;Modernization;multiplex assay;Mutagenesis;Nature;neural network architecture;Non-linear Models;Pattern;Performance;Phenotype;Positioning Attribute;Postdoctoral Fellow;programs;Proteins;Regulatory Element;Research;Research Project Grants;Research Training;Resources;Retinal blind spot;RNA;Schools;Science;Site;skills;Solid;syntax;synthetic data;Technology;tool;Training;Transcriptional Regulation;user-friendly;Variant;Work

PROJECT_TITLE: A surrogate modeling framework for interpreting deep neural networks in functional genomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Precision Medicine;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Anti-tumor adaptive immune system activity is crucial for good prognosis in triple-negative breast cancer (TNBC) patients, but tumors can evolve to escape immune detection, likely leading to worse outcomes. This proposal will characterize one cause of immune evasion–the loss of tumor antigen presentation–and test two potential treatment strategies to overcome this process in breast tumors. This work will be highly relevant to clinical practice and may inform the development and implementation of new therapeutic approaches in TNBC patients.

PI_NAMEs: O'CONNELL, DINA  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;adaptive immunity;Address;Affect;aggressive breast cancer;Agonist;American;Antigen Presentation;Antigen-Presenting Cells;Antigens;B-Lymphocytes;Breast Cancer cell line;breast cancer metastasis;Breast Cancer Patient;cancer diagnosis;cancer subtypes;cancer type;Cell Surface Receptors;Cells;Cessation of life;Characteristics;chemotherapy;Clinic;Clinical;Clinical Data;clinical implementation;clinical practice;Combination immunotherapy;Computer Analysis;CRISPR/Cas technology;cytotoxic CD8 T cells;Data;Data Set;Decitabine;demethylation;Dendritic Cells;Detection;Development;DNA Methylation;Down-Regulation;effective therapy;ERBB2 gene;Exhibits;experimental study;Face;FDA approved;Female;Gene Expression;Growth;Histocompatibility Antigens Class I;HLA Antigens;Human;Hypermethylation;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune Evasion;Immunocompetent;Immunotherapy;improved;in vivo;Infiltration;Knock-out;knockout gene;Macrophage;Major Histocompatibility Complex;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Methylation;MHC Class I Genes;Modality;Molecular;molecular subtypes;mouse model;Mus;Mutate;neoantigens;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Outcome;Pathway interactions;patient prognosis;Patient-Focused Outcomes;Patients;personalized immunotherapy;pharmacologic;Phenotype;Physiology;Population;Prediction of Response to Therapy;predictive marker;Process;Prognosis;prognostic;prognostic indicator;Prognostic Marker;Proteins;Research;response;Role;single-cell RNA sequencing;Surface;targeted treatment;Testing;Therapeutic;TNFRSF5 gene;transcriptome;transcriptomics;translational potential;Treatment Efficacy;treatment strategy;triple-negative invasive breast carcinoma;tumor;Tumor Antigens;Tumor Biology;Tumor Cell Line;Tumor Escape;tumor growth;tumor microenvironment;tumor progression;Tumor-infiltrating immune cells;Woman;Work

PROJECT_TITLE: Characterizing and Overcoming MHC-I-Mediated Immune Evasion in Triple-Negative Breast Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (20)]


PHR: PROJECT NARRATIVE The Protein Processing, Trafficking, and Secretion Gordon Research Conference and Seminar is an extraordinary research conference that brings together scientists with shared interests in the synthesis, trafficking, processing, secretion, and the role of the secretory pathway in human diseases. The purpose of this application is to request financial support for young faculty, postdoctoral fellows, and graduate students to attend this conference.

PI_NAMEs: VON BLUME, JULIA  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Acceleration;Address;Affect;African American;alpha 1-Antitrypsin Deficiency;Alzheimer's Disease;autism spectrum disorder;Autonomic nervous system;Autophagocytosis;Behavior Disorders;Biochemistry;career;Cell Physiology;Cell Surface Proteins;Cellular biology;clinical application;Collaborations;college;Communication;Congenital disorders of glycosylation;cost;Cystic Fibrosis;Dedications;Defect;Development;Diabetes Mellitus;Disease;distraction;diversity and inclusion;Educational workshop;Endocrine System Diseases;Ensure;Environment;Faculty;Familial Hypercholesterolemia;Female;Financial Support;Fostering;Gaucher Disease;Gender;Genes;Genetic;glycosylation;graduate student;Growth;Health;Heart;Hepatolenticular Degeneration;hereditary angioneurotic edema;Hermanski-Pudlak Syndrome;Hispanic Americans;Homeostasis;Human;human disease;Immunity;improved;Individual;Inherited;innovation;insight;interdisciplinary collaboration;Interdisciplinary Study;interest;Knowledge;lectures;Link;lipid transport;London;male;Malignant Neoplasms;Mentorship;Metabolism;Modernization;multidisciplinary;Mutation;Nature;Nervous System Disorder;Neurosciences;neurotransmission;next generation;Niemann-Pick Diseases;novel;novel therapeutic intervention;Obesity;Oral;Organism;Parkinson Disease;Participant;Pathology;Pathway interactions;Patients;Physical condensation;Postdoctoral Fellow;posters;practical application;protein degradation;protein folding;protein misfolding;Protein Secretion;protein transport;Proteins;Quality Control;rare genetic disorder;Research;Research Personnel;Research Project Grants;Research Support;Role;Schizophrenia;Scholarship;Science;Scientific Advances and Accomplishments;Scientist;secretory protein;senior faculty;Series;Signal Transduction;Strategic Planning;Students;symposium;synergism;Talents;Technology;Therapeutic;therapeutic development;therapeutic target;Time;Tissues;tomography;trafficking;Transcend;Translational Research;Translations;Travel;Underrepresented Populations;urban setting;Woman;Zellweger Syndrome

PROJECT_TITLE: 2024 Protein Processing, Secretion, and Trafficking Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (J3)]


NIH_SPENDING_CATS: Brain Disorders;Breast Cancer;Cancer;Estrogen;Neurosciences;Radiation Oncology;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE While endocrine therapy is emerging as a promising strategy for modulating the tumor immune microenvironment, its effectiveness in the context of radiotherapy remains unknown. This proposal will reveal how endocrine therapies synergize with radiotherapy to treat brain metastases in young women at high risk.

PI_NAMEs: CITTELLY, DIANA M. (contact)

PROGRAM_OFFICER_NAME: ARYANKALAYIL, MOLYKUTTY J

PROJECT_TERMS: Age;aggressive breast cancer;anti-tumor immune response;Antigen-Presenting Cells;Antitumor Response;Aromatase Inhibitors;Astrocytes;B-Lymphocytes;bench to bedside;Biology;Brain;Breast Oncology;cancer cell;cancer subtypes;Cell Physiology;Cells;Clinical;clinical practice;Clinical Trials;clinically relevant;Data;Dose;Effectiveness;Effector Cell;ESR1 gene;Estradiol;Estradiol Receptors;Estrogen Receptors;extracellular;FDA approved;Fractionated radiotherapy;Frequencies;Fulvestrant;Future;Genetically Engineered Mouse;Goals;High Risk Woman;hormone therapy;Hormones;Immunocompetent;Immunooncology;immunoregulation;Immunosuppression;In Vitro;innovation;Letrozole;Life;Macrophage;Macrophage Activation;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Metastatic breast cancer;Metastatic malignant neoplasm to brain;Microglia;Modeling;multidisciplinary;Myeloid Cells;Myeloid-derived suppressor cells;Natural Killer Cells;Neoplasm Metastasis;novel;Ovarian;Ovariectomy;Peripheral;pharmacologic;Postmenopause;Pre-Clinical Model;Premenopause;prognostic value;Property;Radiation;radiation resistance;Radiation therapy;Radiation Tolerance;recruit;release factor;Repression;Risk;Role;S100A4 gene;Sampling;Schedule;Scheme;Selective Estrogen Receptor Modulators;Signal Transduction;synergism;T-Lymphocyte;targeted treatment;Testing;Transgenic Model;Translating;Translations;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;Tumor Promotion;Tumor Subtype;tumor-immune system interactions;tumorigenic;Up-Regulation;Woman;women's diagnosis;young woman

PROJECT_TITLE: Mechanisms of endocrine therapy and radiation synergism to decrease brain metastases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-B (02)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Lupus;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Systemic lupus erythematosus (SLE) and associated comorbidities, namely cardiovascular disease (CVD), disproportionately burden Black women and the study of self-management behavioral mechanisms in the specific socio-cultural context of Black women are underexplored. This proposal describes a multi-level, intersectional investigation into these socio-behavioral mechanisms, as influenced by macro-level context, through proposing pathways by which self-management behaviors influence CVD risk in the context of the Superwoman Schema (SWS) among a longitudinal cohort of Black women with SLE. This proposal will advance the knowledge of how to address inequities in SLE by providing a foundation on which to design future disease management interventions and by supporting a junior investigator devoted to a research career in developing and testing multi-level intervention for chronic diseases such as SLE.

PI_NAMEs: LEUNG, JERIK  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Address;Affect;African American Women;Area;Behavior;behavior influence;Behavioral;Behavioral Mechanisms;Behavioral Sciences;biological adaptation to stress;Black American;black men;Black Populations;black women;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;career;caregiving;Chronic Disease;Clinical;cohort;comorbidity;contextual factors;coping;Coping Behavior;Data;Data Analyses;Data Linkages;design;Development;Dimensions;Disease;Disease Management;Disease Resistance;Economics;Environment;Equation;experience;Fellowship;Female;Foundations;Funding;Future;Gender;General Population;Goals;Health;health equity;health inequalities;Health Promotion;Heterogeneity;Household Heads;Hypertension;Image;improved;Individual;Inequity;Infrastructure;instrument;interest;intersectionality;Intervention;Investigation;Knowledge;lens;Lived experience;Longitudinal cohort;Lupus;marginalized population;Mediating;medical schools;Mentors;Mentorship;Methods;Mission;Modeling;Modification;multilevel analysis;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Nature;Neighborhoods;novel;Outcome;outcome disparities;Pathway interactions;Patient Outcomes Assessments;Perception;Persons;population based;Process;programs;promote resilience;prospective;psychologic;Psychometrics;psychosocial;psychosocial stressors;Public Health Schools;Quality of life;Race;racial disparity;Reporting;Research;Research Personnel;resilience;Resources;response;Risk;Risk Factors;Role;Self Efficacy;Self Management;self-management program;Shapes;Smoking;social;Social Behavior;social culture;social health determinants;Social Impacts;Social Processes;Social Responsibility;Social status;Source;Stereotyping;Stress;stressor;Subgroup;Symptoms;Systemic Lupus Erythematosus;Techniques;Testing;theories;Training;Training Support;United States;United States National Institutes of Health;Universities;White Women;Woman;Women's Health;Work

PROJECT_TITLE: Superwoman Coping: A multi-level analysis of self-management behaviors and cardiovascular disease risk among Black women with systemic lupus erythematosus


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Chronic Pain;Neurosciences;Pain Research;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Pain is a hallmark symptom in nearly 75% of individuals with AUD, however, the underlying mechanisms of chronic alcohol withdrawal induced pain (CAWIP) are not known. The parabrachial nucleus of the brainstem controls both behavioral reflexive and affective components of pain. This proposal will investigate changes in Y1 neuron activity and function in the parabrachial nucleus as a result of chronic alcohol exposure.

PI_NAMEs: BRANDNER, ADAM JOSEPH (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Affective;Agonist;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;allodynia;Amygdaloid structure;Area;Attenuated;Behavior;Behavioral;Brain;Brain region;Brain Stem;Bypass;calcium indicator;Cannulations;Chronic;chronic pain;comorbidity;Conflict (Psychology);coping;Coupled;Data;Data Analyses;designer receptors exclusively activated by designer drugs;Development;Disease;Emotional;Ethanol;experience;Experimental Designs;experimental study;Exposure to;Fiber;Frequencies;Genetic;genetic approach;Glutamates;Goals;Halorhodopsins;Hyperalgesia;Hypersensitivity;Immunohistochemistry;Impairment;Implant;Individual;Intake;Ion Channel;Laboratories;Light;Maintenance;Measures;Mechanics;Methods;Modeling;Molecular;Morphine;mRNA Expression;Mus;negative affect;neural;Neurons;neuropeptide Y;Neuropeptide Y Receptor;Nociception;Optics;optogenetics;Pain;pain behavior;pain processing;painful neuropathy;parabrachial nucleus;Pathway interactions;Patients;pharmacologic;Photometry;Physiological;Population;Process;Publications;Publishing;Rattus;receptor;Reporting;Research Personnel;Rodent;Sensory;sex;Signal Transduction;Spinal Cord;Stimulus;Symptoms;System;temporal measurement;Testing;Training;vapor;Virus;Withdrawal;Work

PROJECT_TITLE: Neural intersection of chronic alcohol exposure and pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research;Stroke

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE  Reading impairment is a devastating and nearly ubiquitous consequence of post-stroke aphasia that results in increased processing time for text-based information and the potential abandonment of hobbies and activities (i.e., reading novels or newspaper articles) due to comprehension difficulties. Currently, our clinical understanding of reading deficits relies on behavioral testing which does not provide adequate insight into the underlying breakdowns in written language processing, especially for bilinguals with aphasia who may present with reading difficulties in one or both languages. This project will examine real-time reading comprehension in bilinguals with aphasia to determine how this population navigates literacy post-stroke and to evaluate whether eye tracking measures may inform clinical approaches to bilingual reading assessment.

PI_NAMEs: SCIMECA, MICHAEL DAVID (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TITLE: Assessment of real-time reading comprehension in bilinguals with aphasia

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (32)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHARLESTOWN

ORG_NAME: SPAULDING REHABILITATION HOSPITAL

PHR: PROJECT NARRATIVE  A muscle injury often results in persistent functional declines and impaired mobility in older individuals owing in large part to impaired regenerative responses. With the goal of better understanding the mechanisms underlying these declines over time, we will: 1) investigate how aging of the skeletal muscle extracellular matrix (i.e., the scaffolding material that surrounds all cells) alters the ability of extracellular vesicles to promote functional muscle regeneration, and 2) evaluate whether and how muscle contractile activity reverses these changes. Our long-term goal is to develop novel therapeutics to enhance tissue healing in a geriatric population

PI_NAMEs: AMBROSIO, FABRISIA  (contact);LEDUC, PHILIP R

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acute;Adverse effects;age effect;age related;age related changes;aged;Aging;Architecture;Biogenesis;Biological Models;biophysical properties;Biophysics;Cartilage;Cell Aging;Cell Lineage;Cell Separation;Cells;Characteristics;Collagen;Communication;crosslink;Cues;Data;Defect;design;Distal;Elastic Tissue;Elasticity;Elderly;Engineering;Event;Exercise;Experimental Models;Extracellular Matrix;extracellular vesicles;Fibrosis;functional decline;Functional impairment;Functional Regeneration;Goals;healing;Health;Human;Impairment;improved;In Vitro;in vivo;in vivo Model;Injury;injury recovery;Intramuscular;Investigation;Lipids;loss of function;mechanical load;Mediating;Medicine;Minor;Mitochondria;Mobility decline;Molecular;mouse model;Muscle;muscle aging;Muscle Fibers;muscle progenitor cell;muscle regeneration;nano;Natural regeneration;neuromuscular stimulation;novel;novel therapeutics;Nucleic Acids;older adult;Older Population;osteogenic;Pathogenicity;Pathway Analysis;Physical activity;physical impairment;Physiological;Play;Population;Printing;Process;Property;Proteins;Protocols documentation;Publishing;Recovery of Function;regeneration function;regeneration potential;Regenerative response;Rejuvenation;repaired;Reproducibility;Reserve Cell;resilience;response;Role;scaffold;Signal Pathway;Signal Transduction;Skeletal Muscle;Skeletal muscle injury;Small RNA;Specific qualifier value;stem cell fate;stem cell function;stem cells;Testing;therapeutic development;Time;tissue regeneration;Tissues;transcriptome sequencing;uptake;vesicular release;viscoelasticity;Work

PROJECT_TITLE: The opposing effects of matrix aging and muscle activity on extracellular vesicle promotion of muscle regeneration

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Lung;Microbiome

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Wood smoke exposure has become a growing concern worldwide and has been linked to various respiratory adverse health outcomes, including airway inflammation and disease; however, the mechanism by which this occurs remains unknown. Given that changes in the respiratory microbiome have also been associated with airway inflammation and respiratory disease, investigating its role in the host’s response to wood smoke is significantly relevant to public health, as it offers potential therapeutic and preventive strategies against wood smoke’s adverse effects on respiratory health.

PI_NAMEs: COBOS-URIBE, CATALINA  (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Adverse effects;Air Pollutants;Airway Disease;airway inflammation;Allergic rhinitis;Asthma;Bacteria;Biological Markers;bronchial epithelium;Cell Communication;Cell Survival;climate change;climate impact;Computer Analysis;Data;data integration;Development;Disease;dysbiosis;Environmental and Occupational Exposure;Environmental Exposure;Epithelial Cells;Event;Exposure to;Fellowship;fine particles;Future;Goals;Health;host microbiome;host microbiota;Hour;Human;Human Volunteers;Immune response;In Vitro;in vivo;Individual;Inflammation;Inflammation Mediators;Inflammatory;Inhalation;Inhalation Toxicology;innovation;Knowledge;Learning;Link;liquid chromatography mass spectrometry;Machine Learning;Mediating;Mediation;Medical;metabolome;metabolomics;Microbe;microbiome;microbiome analysis;microbiome components;microbiome composition;microbiome therapeutics;microorganism;Multiomic Data;multiple omics;Outcome;particle;Particulate Matter;pollutant;Prevention strategy;Property;prophylactic;Public Health;pulmonary function;Reporting;Research;Research Personnel;Resolution;respiratory;Respiratory Disease;respiratory health;respiratory microbiome;respiratory microbiota;Respiratory System;response;Role;Scientist;skill acquisition;Source;Staphylococcus aureus;Testing;Therapeutic;Time;Toxicology;Training;training opportunity;Virulence Factors;Wildfire;wood smoke;Work

PROJECT_TITLE: The respiratory microbiome and its role in the host response to wood smoke

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE  By 2050, Alzheimer’s disease and related dementias (ADRD) are estimated to cost the US 1.6 trillion dollars, emphasizing the need to understand their contributing factors. Life course stress has been linked to an increased risk of cardiovascular disease, anxiety, and elevated levels of inflammation which have long-lasting negative effects on an individual’s health, but there is limited research on associations between lifespan stress and ADRD. The overarching goal of this proposal is to examine the associations of early and later-life stress on later-life cognition and plasma biomarkers of ADRD pathology and whether associations differ by sex, in an effort to provide insights for targeted interventions to mitigate ADRD risk.

PI_NAMEs: LEE, JILLIAN  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: adjudication;adverse childhood events;Affect;Age;Ageism;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-42;Amyloid beta-Protein;Anxiety;biobehavior;Biological;Biological Assay;Biological Markers;Biometry;Black race;Blood specimen;Cardiovascular Diseases;cardiovascular disorder risk;caregiving;Chronic stress;Clinical;clinical diagnosis;Cognition;Cognitive;cognitive performance;cohort;Communities;Consensus;cost;cost estimate;Data;Data Analyses;Data Collection;Dementia;dementia risk;Development;Dimensions;disorder risk;Epidemiology;Equilibrium;Ethnic Origin;Event;experience;Exposure to;Family;Feedback;Female;fighting;Financial Hardship;Foundations;Future;Glial Fibrillary Acidic Protein;Goals;Health;healthcare burden;Healthcare Systems;high risk;Impaired cognition;Individual;Inflammation;insight;Intervention;Investigation;late life;Life;Life Cycle Stages;life span;Life Stress;Light;Link;male;Manuscripts;Measures;medical schools;men;Mentorship;Methods;mild cognitive impairment;multidisciplinary;Nerve Degeneration;neurofilament;Outcome;Participant;Pathology;Perception;Personal Satisfaction;Persons;Phosphorylation;Physicians;Plasma;Preparation;prevent;Prevention strategy;prognostic;Psychological Stress;Questionnaires;Race;recruit;Research;Research Personnel;response;Risk;Risk Factors;Role;sex;Sex Differences;skills;Social isolation;Stress;Stressful Event;stressor;Time;Training;Underrepresented Minority;Universities;Woman;Work

PROJECT_TITLE: The Impact of Early and Later-life Stress on Later-life Cognition and Plasma Biomarkers of Alzheimer's Disease and Related Dementias


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative This research fellowship aims to design a useful tool for both gaining fundamental knowledge of viral protein-cell membrane interactions and addressing current challenges in targeted drug- delivery, especially those associated with carrier (delivery vehicle) -cell receptor specificity. By developing adapted cell-free protein synthesis techniques, we intend to construct user-defined proteoliposomes whose composition can mirror an exterior viral surface, used towards either furthering our understanding of virus ligand-host cell interactions or repurposed for targeted therapies exploiting the native fidelity of virus membrane proteins and for their respective cellular receptors.

PI_NAMEs: SELIVANOVITCH, EKATERINA  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: Address;Agriculture;Binding;Biocompatible Materials;Biodistribution;Biological;Biomimetics;Cell Communication;Cell membrane;Cell Membrane Proteins;Cells;Chimeric Proteins;Circulation;Communities;Cytosol;Data;delivery vehicle;design;Doxorubicin;drug candidate;Drug Delivery Systems;Drug Targeting;Elements;Encapsulated;Environment;Event;extracellular;Fellowship;Financial Support;Future;Gene Delivery;Genes;Genetic;glycoprotein G;Glycoproteins;Goals;Health;Hemagglutinin;Human;Human body;improved;In Vitro;Influenza Hemagglutinin;Integral Membrane Protein;Knowledge;Ligands;Lipid Bilayers;Lipids;Liposomes;Location;Mammalian Cell;Measurable;Medicine;Membrane;Membrane Lipids;Membrane Proteins;Methodology;Methods;Modeling;Molecular;nanoparticle;Nipah Virus;Organism;Outcome;particle;pathogenic virus;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Substance;Production;programs;Protein Biosynthesis;Proteins;proteoliposomes;Publishing;Reaction;receptor;Receptor Cell;Recurrence;Research;response;SARS-CoV-2 spike protein;Signal Recognition Particle;Specificity;Structure;Surface;System;targeted treatment;Techniques;Technology;Temperature;Testing;Therapeutic;Tissues;tool;uptake;Vesicle;Viral;Viral Fusion Proteins;Viral Genome;viral genomics;Viral Matrix Proteins;Viral Proteins;Virion;Virus;Work;Zoonoses

PROJECT_TITLE: Designing addressable proteoliposomes by using viral transmembrane proteins and biomimetic cell-free synthesis techniques.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebral Palsy;Clinical Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rehabilitation

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Due to abnormal responses to both expected and unexpected balance challenges, children with cerebral palsy are at an increased risk of falls and resulting injuries. This study will investigate how children with cerebral palsy respond to expected and unexpected balance challenges which mimic functional, daily-life scenarios, and how these responses change with the addition of a secondary, cognitive task. The findings from this study will inform the development of future research studies and facilitate the translation of intervention strategies to clinical practice, improving mobility-based participation and function for children with cerebral palsy.

PI_NAMEs: RUBSAM, MEAGHAN  (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TITLE: The Impact of Cognitive-Motor Interference on Balance Control in Children with Cerebral Palsy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness

ORG_CITY: BINGHAMTON

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: PROJECT NARRATIVE This proposed study seeks to understand how neural reward processing, an important biomarker of depression risk, relates to real-world experiences of pleasure and affect among adolescents at heightened risk of developing major depressive disorder (MDD). The results of this study could further our understanding on how measures of depression risk that are typically studied in the laboratory relate to adolescents’ daily experiences and could help to identify malleable markers of risk that can be targeted in interventions aimed at decreasing risk for MDD.

PI_NAMEs: ISRAEL, ELANA  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Affect;Age;age group;Anhedonia;Biological Markers;Child;child depression;clinically significant;Communities;Data;Data Analyses;depressive symptoms;design;Development;Diagnosis;disability;Ecological momentary assessment;Electroencephalography;Ensure;epidemiology study;Event-Related Potentials;experience;Feedback;FUBP3 gene;Future;Goals;high risk;high risk population;indexing;interest;Intervention;Knowledge;Laboratories;Link;Literature;Major Depressive Disorder;Measures;Mental Depression;modifiable risk;Mothers;Motivation;negative affect;neural;Neurobiology;offspring;Onset of illness;Outcome;Participant;peer;pleasure;Populations at Risk;Process;psychosocial;Public Health;Recording of previous events;Reporting;Research;Research Personnel;response;reward processing;Rewards;Risk;Risk Factors;Risk Marker;Sampling;Series;sex;single episode major depressive disorder;skills;social;suicidal risk;Surveys;Time;Training;Translating;Youth

PROJECT_TITLE: Neural Indices of Social and Monetary Reward Processing as Predictors of Real-World Pleasure and Affect in Adolescents at Risk for Depression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


NIH_SPENDING_CATS: Cystic Fibrosis;Digestive Diseases;Genetics;Lung;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The small intestine has dedicated cell types specialized for its role in nutrient absorption and fluid secretion. The proposed research focuses on the mechanisms driving the fate specification of a unique cell type that expresses very high levels of CFTR (cystic fibrosis transmembrane conductance regulator). This work will contribute to the identification of novel therapeutic targets for intestinal disease associated with CFTR dysregulation, including cystic fibrosis and secretory diarrheal diseases.

PI_NAMEs: ZAGOREN, ELEANOR  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Automobile Driving;Binding Sites;Biological Assay;Cell Count;Cell Differentiation process;Cell Fate Control;cell fate specification;cell type;Cells;ChIP-seq;Colon;Complex;Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Dedications;diarrheal disease;Disease;DNA Binding;effective therapy;Ensure;Enteroendocrine Cell;Epithelial Cells;Epithelium;Fluids and Secretions;Foundations;Gene Expression Profile;Genes;Genetic;genetic manipulation;Genetic Transcription;Germ Cells;Goals;Health;Homeostasis;Human;In Vitro;insight;Intestinal Diseases;intestinal epithelium;intestinal homeostasis;Intestines;knock-down;Knock-out;Knowledge;Mediating;MEIS1 gene;Modeling;Mucous body substance;Mus;new therapeutic target;notch protein;novel;nutrient absorption;Organoids;overexpression;Pathologic;Phenotype;Physiological;Physiology;Population;progenitor;Rattus;receptor;Regulation;Research;Role;Secretory Cell;Signal Transduction;single-cell RNA sequencing;Small Intestines;Sorting;Specific qualifier value;Stains;stem cell differentiation;stem cells;Swelling;System;Testing;Tissues;tool;Training;transcription factor;transcription regulatory network;Work

PROJECT_TITLE: Fate Specification of CFTR High Expresser Cells in the Intestine

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Individuals with autism spectrum disorders have persistent deficits in social communication, but prospective studies indicate disruptions in communication are difficult to detect in early infancy. Infants initiate their first social interactions through cry and previous research supports cry acoustics as an early marker of autism. The proposed study utilizes existing longitudinal data to replicate and extend prior findings of caregiver perception differences of cries from infants later diagnosed with autism and investigate patterns of caregiver- infant interactions involving cry to advance understanding of early social communication development in infants with and without autism.

PI_NAMEs: ANDRES, ERIN MARIE (contact)

PROJECT_TERMS: 1 year old;Acoustics;Address;Adult;Age;Age Months;Area;autism biomarker;Autism Diagnosis;autism spectrum disorder;autism symptoms;autistic;autistic children;Automobile Driving;Behavioral;Brain;career;Caregivers;Characteristics;Child;Clinical;Collection;Communication;Crying;Data;Data Analyses;Development;developmental disease;Diagnosis;Dimensions;Discipline;dyadic interaction;Early Intervention;early screening;experience;Female;Foundations;Frequencies;Functional Magnetic Resonance Imaging;Goals;Grant;Heterogeneity;high risk;Human;Impairment;individuals with autism spectrum disorder;infancy;Infant;Interdisciplinary Study;Intervention;Knowledge;Language;Language Delays;Language Development;language outcome;Lead;Learning;Libraries;Life;longitudinal analysis;longitudinal, prospective study;male;Measurement;Measures;Mediating;Mentors;Modeling;neurobehavioral;Outcome;Pain;Parents;Pattern;Perception;Phenotype;Play;Population;Process;Prospective Studies;Research;Research Personnel;Research Project Grants;Research Support;Research Training;response;Risk;Risk Marker;Role;Sampling;skills;social;social communication;Social Interaction;Source;Special Population;Speech;Statistical Data Interpretation;Structure;Testing;Time;Training;trend;verbal;vocalization;Writing

PROJECT_TITLE: Caregiver Cry Perception and Developmental Trajectories of Infant-Caregiver Interactions Involving Cry as an Early Marker of Autism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


NIH_SPENDING_CATS: Cardiovascular;Neurosciences;Nutrition

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Hypertension and cardiovascular disorders are major contributors to premature death worldwide and their prevalence and severity are exacerbated by excess salt intake. The steroid hormone aldosterone induces sodium intake, but we have a poor understanding of how this occurs. The proposed study will investigate the molecular and genetic changes that occur in specialized aldosterone-sensing neurons after aldosterone treatment which may allow for the future development of therapies to reduce excess salt intake.

PI_NAMEs: MCDONOUGH, MIRIAM  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Ablation;Address;Adult;Aldosterone;Automobile Driving;Brain;Candidate Disease Gene;candidate identification;Cardiac;Cardiovascular Diseases;Cardiovascular Physiology;Cell Nucleus;Central Nervous System;Cessation of life;Chronic;Consumption;CRISPR/Cas technology;Data;Desire for food;Development;epigenomics;Excess Dietary Salt;Excretory function;experimental study;Extracellular Fluid;Fiber;Future;gene discovery;Gene Expression;Genes;Genetic Transcription;Genomics;Glucocorticoids;Goals;Growth;hindbrain;Hormone secretion;Hydroxysteroid Dehydrogenases;Hypertension;in vivo;Intake;Knock-out;loss of function;Measures;Mediating;Mineralocorticoid Receptor;Mineralocorticoids;Molecular;Mus;Mutation;Neurons;non-genomic;optogenetics;Photometry;Physiological Processes;Play;Population;premature;Prevalence;prevent;programs;Receptor Signaling;Recommendation;Regulation;response;Risk;Rodent;Role;salt intake;Severities;Signal Transduction;Sodium;Sodium Channel;Sodium Chloride;steroid hormone;Testing;therapeutic target;therapy development;tool;transcriptomics;Work;World Health Organization

PROJECT_TITLE: Investigating the molecular mechanisms underlying aldosterone-mediated sodium appetite

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F06-L (20)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_DEPT: ADMINISTRATION

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: PROJECT NARRATIVE. The expansion of Medicaid increases health care access for patients experiencing critical illness, half of whom will experience new or worsening physical, mental health or cognitive function after an intensive care unit stay. The proposed work leverages complementary methods and data to understand how sociocultural environments, built environments and health systems influence Medicaid members’ recovery after an intensive care unit stay. By combining Medicaid claims, hospital & community-level public health, interviews and electronic health records datawith health services, qualitative, and machine learning research methods, this project will provide much-needed information to state Medicaid agencies formulating policies to improve the health outcomes of seriously ill patients and advance health equity.

PI_NAMEs: MARKS, SARAH JULIA (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Acceleration;Address;Adult;Affect;American;Area;Award;Beds;Binomial Model;built environment;care seeking;Career Choice;Caring;Censuses;clinical training;Cognitive;cognitive function;Communities;community engaged research;Complex;Critical Care;Critical Illness;Data;Data Set;Data Sources;Dedications;Disparity;disparity reduction;Electronic Health Record;Environment;ethnic minority;Ethnic Origin;experience;Face;Faculty;federal policy;Health;health care availability;health determinants;health disparity;health equity;Health Policy;Health Services;Health Services Accessibility;Health system;hospital readmission;Hospital Units;Hospitals;Housing;improved;Intensive Care Units;Interview;Knowledge;Learning;Link;Low income;Machine Learning;machine learning method;machine learning model;machine learning prediction;Medicaid;Medicaid services;Medical;Medicine;member;Mental Health;Mentorship;Methods;minority health;minority health disparity;Modeling;multidisciplinary;National Institute on Minority Health and Health Disparities;Neural Network Simulation;novel;Outcome;Patient-Focused Outcomes;Patients;perceived discrimination;Performance;physical conditioning;Physical Function;Physicians;Policies;Policy Maker;poor health outcome;Positioning Attribute;predictive modeling;Primary Care;Productivity;Provider;Public Health;Qualitative Methods;Qualitative Research;Race;racial minority;Racial Segregation;racism;Recovery;recurrent neural network;Research;Research Methodology;Research Training;Resources;Risk;Rural Population;rural underserved;rurality;safety net;Scientist;Security;segregation;Shapes;skills;social culture;social deprivation;Social Work;Societies;socioeconomics;Structure;Survivors;survivorship;System;Testing;Time;Training;Translating;Translations;Universities;Virginia;Work

PROJECT_TITLE: Understanding how health determinants shape recovery after critical illness among Virginia Medicaid patients


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Digestive Diseases;Digestive Diseases - (Gallbladder);Liver Cancer;Liver Disease;Precision Medicine;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Relevance to public health Intrahepatic cholangiocarcinoma is a deadly liver cancer with limited treatment options. Recent progress in developing subtype specific treatments have shown the promise of precision medicine for improving outcomes, emphasizing the need for noninvasive diagnosis of thesesubtypes. Leveraging the high sensitivity of hyperpolarized imaging, the proposed work aims to optimize and validate a new approach to bring accurate and rapid diagnostics to patients.

PI_NAMEs: ZAVRIYEV, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: accurate diagnosis;accurate diagnostics;Address;alpha ketoglutarate;behavior in vitro;Biopsy;Carbon;cell type;Cells;Characteristics;Cholangiocarcinoma;Cirrhosis;Clinical;contrast enhanced;Detection;Development;Diagnosis;diagnosis standard;diagnostic strategy;diagnostic value;Disease;Exhibits;experimental study;gain of function;Generations;Goals;Image;Imaging Device;Imaging Techniques;improved outcome;In Vitro;in vivo;Incidence;inhibitor;Intrahepatic Cholangiocarcinoma;Isocitrate Dehydrogenase;Label;Liver Cirrhosis;Magnetic Resonance Imaging;Malignant neoplasm of liver;Measures;Metabolism;minimally invasive;Molecular;Molecular Analysis;Monitor;mouse model;mutant;Mutate;Mutation;mutational status;non-invasive imaging;noninvasive diagnosis;novel;novel diagnostics;novel strategies;novel therapeutics;patient derived xenograft model;patient population;Patients;Perfusion;phantom model;Phase;phase III trial;Physiologic pulse;precision medicine;Prediction of Response to Therapy;preservation;Primary carcinoma of the liver cells;Procedures;Production;Prognosis;protein expression;Public Health;Rapid diagnostics;Reporting;Reproducibility;response;Risk Factors;Signal Transduction;small molecule inhibitor;Specificity;Surrogate Markers;Survival Rate;System;Techniques;Time;treatment duration;treatment response;treatment strategy;tumor;ultrasound;United States;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Noninvasive assessment of IDH mutation status in intrahepatic cholangiocarcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-D (20)]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: NEW YORK

ORG_DEPT: CHEMISTRY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE  Cancer cells rely on non-canonical DNA damage repair mechanisms to stabilize their genomes, and these pathways are often non-essential in healthy tissues and thus represent therapeutic opportunities. In this proposal, a multidisciplinary approach will be leveraged to develop a covalent inhibitor for a recently discovered genome maintenance pathway dependent on the protein cancerous inhibitor of protein phosphatase 2A (CIP2A). Proposal success will both provide valuable chemical tools to understand CIP2A function and lay the foundation for therapeutics to inhibit this protein and its role across various cancer types.

PI_NAMEs: HEISS, TYLER  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Address;analog;Animals;anti-cancer research;azetidine;Binding;Binding Sites;Biological Assay;Biology;brca gene;BRCA mutations;Cancer Biology;cancer cell;cancer type;Cancerous;Cell Cycle;Cell division;Cell Line;Cell Survival;Cells;Centromere;Chemicals;chemoproteomics;Chromosomes;chromothripsis;Collection;Communities;Complex;computational chemistry;Computer Analysis;Cysteine;Data;Dependence;design;Development;Disease;DNA Damage;DNA Maintenance;DNA Repair;DNA Sequence Rearrangement;drug discovery;drug standard;Ensure;Exhibits;Fellowship;Foundations;Future;Generations;Genome;Genome Stability;genome-wide;Goals;homologous recombination;homologous recombination deficiency;improved;In Vitro;in vivo;Incubated;inhibitor;innovation;interdisciplinary approach;knock-down;Label;Lead;Letters;Ligands;loss of function;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mentors;Mentorship;Methods;micronucleus;Microscopy;Mitosis;Oncogenic;Oncoproteins;Pathway interactions;Phenotype;prevent;Process;professor;Property;Protac;Protein phosphatase;Protein Phosphatase Inhibitor;protein protein interaction;Proteins;Proteomics;Reaction;Recombinant Proteins;recruit;Research;Role;Route;scaffold;segregation;Site;small molecule;Structure;success;Surface;Testing;Therapeutic;therapeutically effective;Tissues;tool;TOPBP1 Gene;Toxic effect;Training;tumorigenesis;ubiquitin-protein ligase;Universities;Work

PROJECT_TITLE: Chemoproteomic discovery and characterization of covalent ligands for the oncoprotein CIP2A, a unique vulnerability in BRCA1/2-deficient cancers


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Infectious Diseases;Prevention;Rare Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Project Narrative Enterococci cause as much as 26% of all cases of infective endocarditis (IE), a disease among the most challenging to treat with mortality rates often exceeding 30%. To date, there is a dearth of evidence to explain patient and bacterial factors most important for the transition from enterococcal bacteremia to IE. The proposed research will use genomics, proteomics, dense and well-integrated patient health data, and follow up in vitro studies to disentangle factors associated with enterococcal IE to inform diagnostic, therapeutic and intervention strategies to curb these infections.

PI_NAMEs: SMITH, JOSHUA THOMAS (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: acute infection;Address;Adherence;Age;Alberta province;Animal Model;Antibiotics;Automobile Driving;Bacteremia;Bacteria;bacterial genetics;bactericide;Biological Models;Blood;Blood Circulation;Canada;Cells;Characteristics;Clinical;Clinical Treatment;Collection;Communities;Community-Acquired Infections;comorbidity;Complement;Cues;Data;Data Scientist;Data Set;Death Rate;demographics;Development;Diagnostic;differential expression;Disease;Enterococcus;Enterococcus faecalis;Environment;epidemiology study;Exhibits;follow-up;Future;Gene Expression;Genes;Genetic;genetic variant;Genetic Variation;genome wide association study;genomic data;Genomics;Goals;Health;health data;Health system;Healthcare;Heart;Heart Valve Prosthesis;Heart Valves;Human;Human Resources;Immune;improved;In Vitro;Infection;infection risk;Infective endocarditis;innovation;insight;Integration Host Factors;Intervention;Invaded;Link;Maps;medical schools;Metadata;microbial;Microbial Biofilms;Microbial Genetics;microbial genome;Modeling;Molecular;multiple omics;pathogen;pathogen genome;Pathogenesis;Pathogenicity;Pathway interactions;patient health information;Patient risk;Patients;Pattern;Phenotype;Phylogenetic Analysis;Pilum;Population;Population Dynamics;Postdoctoral Fellow;Predisposing Factor;Prognosis;progression risk;Proliferating;Prosthesis;protein expression;Proteins;Proteome;Proteomics;Publications;Publishing;Research;Research Personnel;Resistance;Resources;Risk;Risk Assessment;Risk Factors;Role;Route;skills;Structure;Study models;Systemic infection;Talents;Technical Expertise;Therapeutic;Tissues;Training;transcriptome;Translations;urban area;Validation;Variant;Virulence Factors;whole genome;Work

PROJECT_TITLE: Deep integration of multi-omics and patient health data to clarify risk factors of enterococcal infective endocarditis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Data Science

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The development of general single-atom skeletal editing reactions enables the rapid synthesis and evaluation of a broader scope of core-modified derivatives of bioactive compounds during medicinal and agrochemical discovery campaigns. The photomediated ring contraction of saturated heterocycles exemplifies a highly enabling reaction of this class, but is currently difficult to apply in a real-world context due to limitations in scope, lack of understanding of the most efficient wavelength to use, and variability in enantioselectivity. Expansion of the scope by leveraging peripheral functionalization chemistry, characterization of mechanism and wavelength- dependent reactivity, and data science driven rationalization of enantioselectivity trends will elucidate fundamental understanding and enable application of this knowledge to the optimization of the ring contraction for more general and highly enantioselective applications in health-related industries.

PI_NAMEs: KIM, SOJUNG FRANCES (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TITLE: Photomediated ring contractions of N-Aryl azacycles: Mechanistic insights and characterization of wavelength dependent reactivity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


NIH_SPENDING_CATS: Aging;Genetics;Neurosciences;Sarcopenia

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative The decline of physical function with aging is a critical public health concern, given the strong association between frailty, muscle weakness, and adverse health outcomes in the elderly. This project aims to investigate the role of L-kynurenine (L-Kyn) and the aryl hydrocarbon receptor (AHR) in exacerbating physical function deterioration during aging. Understanding the mechanisms underlying age-related physical decline could lead to the development of novel interventions to attenuate frailty and muscle weakness and improve the quality of life for the elderly.

PI_NAMEs: WIMBERLY, KEON  (contact)

PROJECT_TERMS: Academia;Acute;Age;age acceleration;age related;age related decline;Aging;aging process;Animals;Area;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Atrophic;Attention;Attenuated;Biology;Biology of Aging;Body Weight;career development;Catabolism;Cells;Cessation of life;Characteristics;Chronic;clinical practice;Communication;Control Groups;Coupled;Cytochrome P450;Cytosol;Data;decrease resilience;Deterioration;Development;Diet;disability;Disease;Drug Metabolic Detoxication;drug testing;Elderly;Enzymes;Event;FDA approved;Fellowship;Foundations;frailty;functional decline;Gene Expression;gene function;Genes;Genetic;Genome;GOT2 gene;Hand Strength;Health;Healthcare Systems;healthy aging;high risk;Histones;Human;improved;In Situ;Individual;Institution;Intervention;Knockout Mice;Kynurenic Acid;Kynurenine;Kynurenine-oxoglutarate aminotransferase;Leadership;Learning;Life Expectancy;Ligands;Link;Measures;Metabolic Biotransformation;Mitochondria;mitochondrial dysfunction;Molecular Biology;mortality;Motor Neurons;mouse model;multiple omics;Mus;Muscle;muscle aging;muscle form;Muscle function;muscle physiology;Muscle Weakness;Muscular Atrophy;neuromuscular;Neuromuscular Junction;neuron loss;neuroprotection;novel;Organism;Outcome;overexpression;Oxidative Phosphorylation;Pathway interactions;Phenotype;Physical Function;Physiological;Physiology;Play;Positioning Attribute;Program Development;Protein Isoforms;Proteolysis;Proteome;Public Health;Quality of life;Receptor Activation;Reporting;Research;Research Training;Risk;Risk Factors;Role;sarcopenia;Scientist;Skeletal Muscle;skeletal muscle wasting;stressor;System;Talents;Techniques;tenure track;Testing;Tissues;Toxic effect;Training;transcription factor;transcriptome;Tryptophan;Ubiquitin;ubiquitin-protein ligase;vector;walking speed

PROJECT_TITLE: Targeting muscle kynurenine aminotransferases and the AHR pathway to mitigate age-related physical decline


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Nutrition;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Pancreatic ductal adenocarcinoma (PDAC) is characterized by RAS and autophagy-dependent growth, and dual inhibition of the RAS-ERK MAPK and autophagy pathways is a potential treatment strategy for PDAC. One aim of this study will assess whether prolonged inhibition of the RAS-ERK MAPK pathway results in compensatory upregulation of another nutrient scavenging pathway, macropinocytosis, and whether this process mediates resistance to dual RAS-ERK MAPK and autophagy pathway inhibition. Additionally, I demonstrate that ERK inhibition results in increased macropinocytosis and hypothesize that this could be exploited to increase delivery of albumin-bound therapeutics such as nab-paclitaxel, which is currently second-line treatment for PDAC.

PI_NAMEs: ROBB, RYAN  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Affect;Albumins;anti-cancer therapeutic;Automobile Driving;Autophagocytosis;Binding;Biogenesis;Biological Assay;Biology;Cancer Etiology;career development;Cell Line;Cells;Cessation of life;Chloroquine;Cholesterol;Chronic;Clinical Data;Combined Modality Therapy;Compensation;Confocal Microscopy;cytotoxicity;Data;Dedications;Dependence;design;Development;Down-Regulation;Drug Delivery Systems;Evaluation;Extracellular Protein;Fatty Acids;Flow Cytometry;Fostering;Future;Genetic;glucose uptake;Glycolysis;Growth;Growth and Development function;In Vitro;in vivo;inhibition of autophagy;inhibitor;KRAS oncogenesis;KRAS2 gene;Left;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;MEKs;Metabolic;Metabolic Pathway;Metabolism;Microscopy;Mitogen-Activated Protein Kinases;Monitor;Mutation;Necrosis;Nutrient;nutrient deprivation;Oncoproteins;Paclitaxel;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathway interactions;Patients;pharmacologic;Physiologic pulse;pre-clinical;Process;Proliferating;Proteins;RAS inhibition;Ras/Raf;Regulation;Research Personnel;Resistance;Role;Signal Transduction;Survival Rate;targeted treatment;Testing;Therapeutic;therapeutic development;therapeutic target;therapy development;Time;treatment strategy;tumor;tumor growth;Tumor Promotion;tumor specificity;tumor xenograft;tumorigenic;Up-Regulation;uptake;Western Blotting;Work

PROJECT_TITLE: Mechanistic examination and inhibitor targeting of nutrient scavenging for the treatment of pancreatic cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-Z (20)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE The mesolimbic dopamine system is at the core of stimulus processing, and its dysregulation by cocaine use results in deficits in the ability to appropriately respond to biologically important information outside of the drug context. In order to identify potential therapies targeting these systems, it is paramount to fully understand how dopamine signaling is involved in basic neural functions that support adaptive learning and motivation. In this proposal, I will define how dopamine release in the nucleus accumbens organizes local neural activity around interaction with salient stimuli, and identify how dopamine's capacity to modulate striatal function changes as a consequence of chronic cocaine use.

PI_NAMEs: LEONARD, MICHAEL Z. (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Action Potentials;Acute;Adaptive Behaviors;adaptive learning;addiction;Affect;Animal Model;Animals;Aversive Stimulus;awake;Behavior;Behavioral;Brain;Calcium;cell type;Cells;Chronic;Cocaine;cocaine self-administration;cocaine use;Cocaine use disorder;comparative efficacy;Corpus striatum structure;Data;design;Desire for food;Dopamine;Dopamine Receptor;Drug usage;Environment;experience;Functional disorder;Goals;Halorhodopsins;Home;Human;human model;Image;Impairment;Individual;Investigation;Lead;Maps;mesolimbic system;Midbrain structure;Modeling;Motivation;Mus;neural;Neuromodulator;Neuronal Dysfunction;Neurons;Neurophysiology - biologic function;Neurotransmitters;non-drug;Nucleus Accumbens;Optics;optogenetics;Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;Population;population based;postsynaptic neurons;Pre-Clinical Model;Preparation;Process;Recording of previous events;recruit;Research;response;Response to stimulus physiology;Saline;segregation;Self Administration;Services;Shock;Signal Transduction;Slice;stimulant exposure;Stimulus;stimulus processing;System;targeted treatment;Testing;Time;tool;Training;Treatment outcome;Update

PROJECT_TITLE: Defining Disruptions to Dopaminergic Control of Striatal Activity after Chronic Cocaine Use

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]