PI_NAMEs: ANCES, BEAU M (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Affect;Age;AIDS clinical trial group;antiretroviral therapy;Attention;Award;Biometry;Budgets;Cardiovascular Diseases;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Unit;cognitive function;Cohort Analysis;collaborative environment;Collection;Communities;comorbidity;Complex;Consultations;Consumption;Creativeness;Data;Data Collection;data management;design;Development;Diabetes Mellitus;Drug usage;Enrollment;Ensure;Environment;Epidemic;Epidemiologic Methods;Ethics;Event;experience;Exploratory/Developmental Grant;Face;Fostering;Funding;Generations;Grant;HIV;HIV Seropositivity;housing instability;Human Subject Research;Impaired cognition;improved;Infrastructure;injection drug use;innovation;insight;Institution;Instruction;Interdisciplinary Study;Investigator-Initiated Research;investigator-initiated trial;Investments;Laboratories;Leadership;Long-Term Care;Malignant Neoplasms;Measures;Mental Health;Metabolic Diseases;Methods;Midwestern United States;Missouri;Modeling;Network-based;Neurologic;Neurologist;Newly Diagnosed;novel;Pathway interactions;Persons;Population;Population Heterogeneity;Positioning Attribute;Prevention;Process;protocol development;racial minority;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;response;Services;Surveys;Survival Analysis;syndemic;synergism;Techniques;Testing;Thinking;Time;Training;Underrepresented Populations;United States National Institutes of Health;Universities;Washington;Work;years of life lost

PROJECT_TITLE: Clinical Science Core


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PI_NAMEs: MCKAY, VIRGINIA R (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adoption;AIDS prevention;Area;Award;base;Cessation of life;Cities;Collaborations;Communities;Community Health;community organizations;Consultations;County;crowdsourcing;Development;Dissemination and Implementation;dissemination science;Ecosystem;effective therapy;Epidemic;epidemic response;Etiology;Evaluation;evidence base;Evidence based intervention;Face;Fostering;Funding;Goals;Grant;Growth;Guidelines;Health system;HIV;HIV diagnosis;HIV/AIDS;implementation research;implementation science;implementation strategy;Infrastructure;innovation;Institution;interest;Intervention;Investments;Life;Methods;Midwestern United States;Missouri;Modality;Modeling;Outcome;Participant;Pathogenesis;pedagogical content;Positioning Attribute;Prevention;Process;Productivity;programs;Public Health;Publications;racial health disparity;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Personnel;Resources;response;Science;Services;Testing;theories;Training;Universities;Virginia;Washington;Work

PROJECT_TITLE: Dissemination & Implementation Science Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 KSW-A (J2)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

PI_NAMEs: DURKIN, MICHAEL JOSEPH (contact)

PROJECT_TERMS: Academic Medical Centers;Academic support;Acquired Immunodeficiency Syndrome;Address;Adult;Affect;aged;antiretroviral therapy;Area;Award;base;black men;black women;Businesses;Capital;Caring;Cause of Death;cohort;Collaborations;combat;Communities;community based research;community involvement;community organizations;community partners;Compensation;Consensus;Coupled;Decision Making;Dedications;Development;Disease Outbreaks;Disparity;Environment;Epidemic;Epidemiology;experience;Face;Feedback;forging;Fostering;Foundations;Funding;Funding Mechanisms;Goals;Group Structure;Harm Reduction;health care delivery;Health Services;Hepatitis C Therapy;High Prevalence;high risk;HIV;Homelessness;improved;Incubators;Infection;Infrastructure;Injecting drug user;injection drug use;innovation;Institution;Interdisciplinary Study;interest;Intervention;Investments;Left;Mainstreaming;Medicine;meetings;member;men;Mentors;Midwestern United States;Missouri;Morbidity - disease rate;mortality;neglect;novel;Overdose;pandemic disease;Participant;patient population;Persons;Population;Positioning Attribute;pre-exposure prophylaxis;Prevalence;Prevention;Process;programs;Public Health;Reporting;Research;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;Research Proposals;response;Risk;Rural;rural area;Rural Health;service providers;Sexually Transmitted Diseases;Shelter facility;Site Visit;stem;success;syndemic;Targeted Research;Techniques;telehealth;Time;trend;underserved community;Universities;violence prevention;Vision;White Women;Work;working group;Writing

PROJECT_TITLE: Scientific Working Group


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Obsessive compulsive disorder (OCD) is a debilitating psychiatric illness with inadequate treatment options. Negative reinforcement theories of OCD assert that compulsive behaviors are performed to avoid obsession- evoked anxiety, and clinical studies have implicated the medial orbitofrontal cortex (mOFC) as a key region mediating excessive avoidance in OCD and a potential treatment target. In this proposal, we will investigate how the mOFC encodes negative reinforcement learning in mice and dissect the relative contributions of projection- specific mOFC neural populations.

PI_NAMEs: CHAMBERLAIN, BRITTANY LYNN (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Adaptive Behaviors;Amygdaloid structure;Anxiety;avoidance behavior;Avoidance Learning;Behavior;Behavioral;Calcium;career;Cells;Chronic;Clinical Research;clinically relevant;Color;Communication;Complex;compulsion;Compulsive Behavior;Computer Analysis;Conditioned Stimulus;Cues;Data;Decision Making;Desire for food;Development;Elements;Environment;Etiology;Event;excitatory neuron;Exhibits;experience;Fellowship;Future;Goals;Image;Impairment;in vivo;in vivo calcium imaging;insight;Knowledge;Learning;Maintenance;Measures;Medial;Mediating;Mental disorders;Mentors;Mentorship;microendoscopy;Modeling;Monitor;Motivation;Mus;Negative Reinforcements;neural;neural circuit;Neurons;novel;Nucleus Accumbens;Obsession;Obsessive-Compulsive Disorder;optogenetics;Outcome;Pathway interactions;Patients;Phase;Physicians;Population;Positioning Attribute;Prediction of Response to Therapy;Prevention;Punishment;Recommendation;reduce symptoms;reinforced behavior;Research;response;Rewards;Role;Scientist;segregation;sensory stimulus;Shock;Source;Symptoms;Technical Expertise;theories;therapeutic target;Training;Transcranial magnetic stimulation;Translating;treatment response;Universities

PROJECT_TITLE: Investigating the role of the medial orbitofrontal cortex (mOFC) in negative reinforcement learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE The ACCESS implementation strategy seeks to support syringe services programs in adopting, implementing, and sustaining opt-out HIV/HCV testing through external facilitation and funding to increase the reach of HIV/HCV testing in people who inject drugs (PWID). We urgently need a strong evidence base to prove that the ACCESS strategy can help us increase diagnosis, prevention, and treatment of HIV in PWID. We seek to set the foundation to build, implement, and scale-up a new standard of care for comprehensive HIV services for PWID in non-stigmatizing settings.

PI_NAMEs: BARTHOLOMEW, TYLER SCOTT (contact);TOOKES, HANSEL EMORY

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Acute Hepatitis C;acute infection;Adopted;Adoption;AIDS prevention;Caring;Client;Cluster randomized trial;Communities;Community Health;comparison control;Comprehensive Health Care;Cost Analysis;cost effectiveness;Cost Effectiveness Analysis;Data;Diagnosis;Disease Outbreaks;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Enrollment;Environment;Epidemic;Epidemiology;Equity;evidence base;Evidence based intervention;Face;Federally Qualified Health Center;Florida;follow-up;Foundations;Funding;gender minority;Goals;health care settings;Hepatitis C;HIV;HIV Infections;HIV/HCV;Human immunodeficiency virus test;Hybrids;implementation evaluation;implementation fidelity;implementation strategy;implementation/effectiveness;Improve Access;improved;Incidence;Infection;Injecting drug user;injection drug use;Institution;Intervention;Link;Locales;meetings;Methods;Modeling;Needle-Exchange Programs;organizational readiness;Outcome Study;Overdose;Participant;peer;Persons;Phase;pilot test;Policies;Population;pre-exposure prophylaxis;prevent;Prevention;primary care clinic;primary outcome;Procedures;racial minority;Randomized;Recommendation;recruit;Reporting;Research;Resources;Role;scale up;screening;service programs;Services;Site;Site Visit;standard of care;Testing;testing access;testing services;testing uptake;Training;Trust;uptake;web site

PROJECT_TITLE: Project ACCESS: Advancing Equitable Access to HIV/HCV Testing Through Structural Transformation in Syringe Services Programs: A Cluster Randomized Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 TXT-E (J1)]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: KINGSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE Disaggregating longitudinal patterns and correlates of alcohol and cannabis (AC) co-use in young people who are already engaged in alcohol use is essential to informing potential targets for clinical and public health intervention, particularly for providers in states navigating the emergence of novel recreational cannabis laws (RCLs). The F31 applicant will identify latent profiles and transition patterns of adolescent AC co-use (e.g., additive or substitution effects) and examine how multidimensional SES (mSES) and cannabis policy context are associated with these trajectories. The training plan is designed to provide rich training in adolescent development, addiction, advanced longitudinal modeling, and an initial exploration into differential patterns for underrepresented youth, providing critical protected research time for the applicant to build and launch a career as an independent NIH-funded scientist.

PI_NAMEs: KENYON, EMILY A (contact)

PROGRAM_OFFICER_NAME: PARASURAMAN, SARIKA RANE

PROJECT_TERMS: addiction;Adolescent;Adolescent Development;Age;age group;Alcohol consumption;Alcohols;Back;Birth;Cannabis;Cannabis policy;career;Career Choice;Characteristics;Child;Clinical;clinical practice;Collaborations;Curiosities;Data;Decision Making;design;Dimensions;disadvantaged background;Doctor of Philosophy;drinking;Economics;Education;Educational process of instructing;Environment;Ethnic Origin;Evolution;Family;Female;follow-up;Frequencies;Funding;gender minority status;Health;Healthcare;Hispanic;Incidence;Income;indexing;Individual;Institution;Intervention;Latino;Legal;Literature;marijuana use;Measures;Mentors;Methods;Modeling;National Institute on Alcohol Abuse and Alcoholism;Nature;novel;Parents;Pattern;Perception;Persons;Play;Policies;Prevention;preventive intervention;Probability;programs;Provider;Public Health;public health intervention;Public Health Practice;Public Policy;Publications;Publishing;Race;Recreation;Research;Rhode Island;Role;Sampling;Scientist;sex;Sexual and Gender Minorities;skills;social;social disparities;Social Environment;sociodemographics;Socioeconomic Status;Statutes and Laws;Subgroup;Substance Addiction;substance use;Time;timeline;Training;Training Programs;underage drinking;United States National Institutes of Health;Universities;Work;Writing;Youth

PROJECT_TITLE: Adolescent alcohol and cannabis transitions: Associations with multidimensional SES and cannabis policy

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Patient Safety;Pediatric;Prescription Drug Misuse;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE There have been major changes in the landscape of prescribing controlled substances (eg, benzodiazepines, opioids, and stimulants) in the US over the past three decades including a steady increase in prescribing opioids for two decades (1990-2010) followed by sharp decreases in opioid prescribing and major increases in stimulant prescribing, especially among middle-aged and older adults. The shifts in medical use of prescription drugs have important implications for the etiology of nonmedical prescription drug misuse and associated consequences; however, there has been relatively little consideration of the developmental relationships between the initiation and discontinuation of medical use of prescription medications and subsequent substance-related adverse consequences (eg, drug overdose deaths, all-cause mortality, substance use disorder symptoms) within the same individuals. This renewal will help inform clinical, prevention, policy, and regulatory efforts by identifying trajectories of medical use of prescription medications from adolescence up to older adulthood and by examining how these trajectories are associated with other drug use and adverse consequences using US nationally longitudinal samples while considering variations by age, cohort, sex, race/ethnicity, and education.

PI_NAMEs: MCCABE, SEAN ESTEBAN (contact)

PROGRAM_OFFICER_NAME: PARKER, ERIN MARGARET

PROJECT_TERMS: Acceleration;Address;Adolescence;Adult;adverse outcome;Age;age difference;Attention deficit hyperactivity disorder;Benzodiazepines;Cessation of life;Clinical;Clinical Practice Guideline;cohort;Combined Modality Therapy;Communities;community-level factor;Data;Data Sources;Death Records;Development;Drug abuse;drug misuse;Drug Prescriptions;Drug usage;Education;Effectiveness;Ethnic Origin;Etiology;Frequencies;Future;Health;health care availability;Health Professional;high risk;indexing;Individual;innovation;Knowledge;life span;Link;Literature;Medical;middle age;misuse of prescription only drugs;Modality;Modeling;Monitor;mortality;older adult;Opioid;Overdose;overdose death;Pharmaceutical Preparations;Policies;polysubstance use;prescription opioid;prescription stimulants;Prevention;prospective;Prospective Studies;protective factors;Public Health;Race;Recording of previous events;Research;response;Risk;Risk Factors;Sampling;Schedule;secondary analysis;sedative;sex;social;Societal Factors;Source;Stimulant;stimulant exposure;substance use;Substance Use Disorder;Symptoms;Time;Tranquilizing Agents;twelfth grade;United States National Institutes of Health

PROJECT_TITLE: Trajectories of Prescription Nonmedical Drug Misuse

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 LXF-E (J1)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Patient Safety;Physical Activity;Physical Rehabilitation;Prevention;Rare Diseases;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: BOSTON

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: PROJECT NARRATIVE Exercise plays a vital role in the physical fitness and well-being of patients diagnosed with multiple myeloma. The proposed research sub-analysis will examine the effect of a prehabilitative aerobic and resistance exercise intervention in patients with multiple myeloma scheduled to receive autologous stem cell transplant, designed to assess the feasibility of exercise. This research will address the question of whether novel timing, prior to autologous stem cell transplant, is an intervention strategy that improves muscular strength in multiple myeloma patients.

PI_NAMEs: NORMANN, AMBER  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Admission activity;Adverse event;Aerobic Exercise;Age;Age related comorbidities;Autologous Stem Cell Transplantation;Biology;Body Composition;cancer prevention;cancer therapy;cardiometabolism;cardiovascular fitness;career;Certification;chemotherapy;Chronic;Clinical;Clinical Trials;clinically relevant;comorbidity;comorbidity Index;Dana-Farber Cancer Institute;deconditioning;Dedications;design;Diagnosis;Disease;Disease remission;Eligibility Determination;Exercise;exercise intervention;exercise physiologist;Exercise Physiology;exercise training;experience;extend lifespan;Fatigue;Fellowship;fitness;Foundations;frailty;functional status;Glucose;Goals;Habilitation;Health;Hematologic Neoplasms;Home;hospital readmission;Hospitalization;Immunocompromised Host;improved;Individual;Institutional Review Boards;Insulin;Insulin Resistance;Intensive Care Units;Intervention;Knowledge;Length of Stay;Mentorship;Metabolic syndrome;Multiple Myeloma;Muscle;muscle form;muscle strength;National Research Service Awards;novel;Oncology;Outcome;Patient Outcomes Assessments;patient population;Patients;Personal Satisfaction;personalized care;Phase;Physical Capacity;Physical Fitness;Physical Function;Play;Population;post-transplant;Postoperative Complications;Postoperative Period;Prognosis;programs;Progression-Free Survivals;psychologic;Quality of life;Randomized, Controlled Trials;readmission rates;reduced muscle strength;Research;Research Personnel;resistance exercise;Risk;risk minimization;Role;sarcopenia;sarcopenic obesity;Schedule;Skeletal Muscle;skills;standard of care;Supervision;survivorship;Symptom Burden;Testing;Therapeutic Intervention;Time;Training;Training Programs;Transplantation;treatment as usual;Unfavorable Clinical Outcome;virtual;virtual delivery

PROJECT_TITLE: Prehabilitation Exercise Training in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: COLD SPRING HARBOR LABORATORY CONFERENCE  MECHANISMS AND MODELS OF CANCER  August 13 - 17, 2024  Cancer is a collection of deadly diseases that will afflict one out of every two to three people in the developed world during their lifetime. In recent years, great progress has been made in understanding how cancer develops and progresses. Ever more sophisticated and elegant models of human cancer have been developed for most types of cancer, and we understand in great detail the molecular and cellular changes that promote disease development. Collectively, these advances are improving both the quality of life and overall survival of cancer patients. Yet despite these advances, huge challenges remain. While “targeted” therapies can result in dramatic clinical response, these are typically transient, necessitating that we understand resistance to develop rational drug combinations. Immune-based therapies have led to remarkable responses-including cures—in select patients, but the side effects of these therapies can be substantial and most cancers remain refractory to current agents. To stimulate innovation and cross- disciplinary interactions in this rapidly advancing field, we propose to convene a group of outstanding basic and clinical researchers studying the development and progression of cancer in a variety of model systems, in an international meeting entitled Mechanisms and Models of Cancer at Cold Spring Harbor Laboratory in August 2024.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Antibodies;Area;Biochemical;Biological;Biological Models;Cancer Biology;cancer cell;Cancer Center;cancer genome;Cancer Model;Cancer Patient;cancer prevention;cancer survival;cancer therapy;cancer type;carcinogenesis;career;Cellular biology;Clinical;Collection;Computational Biology;Data;data exchange;Development;Disease;Drug Combinations;Ensure;Environment;Epigenetic Process;epigenome;Equilibrium;Evolution;Faculty;Fostering;functional genomics;Future;Genetic;Genomics;Goals;graduate student;Heterogeneity;human model;Immune response;Immunologics;Immunotherapy;improved;In Vitro;in vivo;Individual;innovation;insight;interest;International;Investigational Therapies;Laboratories;laboratory facility;Laboratory Scientists;Lead;lectures;Length of Stay;Malignant Neoplasms;meetings;member;Metabolic;Minority;Modeling;Molecular;Monitor;NCI Center for Cancer Research;Neoplasm Metastasis;next generation;notch protein;novel therapeutic intervention;novel therapeutics;Oncogenes;Oncogenic;Oral;Organoids;Participant;Patient Selection;Patients;Persons;Postdoctoral Fellow;posters;Process;Proliferating;prospective;protein complex;Proteins;Published Comment;Quality of life;Refractory;Research;Research Institute;Research Personnel;Resistance;response;Schedule;Scientist;Series;side effect;Signal Transduction;Signs and Symptoms;small molecule inhibitor;stem cells;structural biology;success;symposium;targeted cancer therapy;targeted treatment;Technology;technology development;Testing;Therapeutic;three dimensional structure;Training;tumor;tumor heterogeneity;tumor immunology;tumor metabolism;tumor microenvironment;tumor progression;Tumor Suppressor Genes;Universities;unpublished works;Update;Woman;Work

PROJECT_TITLE: CSHL 2024 Mechanisms & Models of Cancer Conference

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (J1)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The realization of Plasmodium vivax's ability to invade red blood cells of Duffy negative individuals and occurring commonly in Africa changed the paradigm of our understanding of Plasmodium vivax biology. However, the underlying mechanisms of this phenomenon are yet to be understood. This proposal will provide career development, through didactic and mentored training, for a promising MD/PhD student to investigate potential mechanisms using a combined in vitro and in vivo approach that leverages advanced genomic and bioinformatic techniques.

PI_NAMEs: CONNELLY, SEAN  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Africa;Africa South of the Sahara;African;Antigen Receptors;Antigens;Belief;Binding;Binding Proteins;Bioinformatics;Biological Assay;Biology;Blocking Antibodies;Blood Group Antigens;Blood Vessels;career;career development;Cell Cycle Stage;Cell Line;Cell Separation;Cells;chemokine receptor;Clinical;clinical practice;Communicable Diseases;Complex;computational pipelines;computerized tools;Culicidae;Dependence;Development;differential expression;doctoral student;Education;Erythrocytes;experimental study;Fluorescence-Activated Cell Sorting;Frequencies;Gene Expression;Gene Expression Profile;Genes;genomic tools;Genomics;global health;Health;High Prevalence;Human;In Vitro;in vitro Model;in vivo;Individual;Infection;insight;Intervention;Invaded;Knowledge;Left;Ligands;Liver;Madagascar;Malaria;Maternal Health;Measures;Mentors;Methods;Modeling;Molecular;Monoclonal Antibodies;Natural Resistance;Nature;nonhuman primate;novel;novel marker;novel strategies;Parasites;Pathogenesis;Pathology;Pathway interactions;Phenotype;Physicians;Plasmodium;Plasmodium falciparum;Plasmodium knowlesi;Plasmodium vivax;Pregnancy;Prevalence;Process;programs;public health intervention;Relapse;Reporting;Research;Sampling;Scientist;Sexual Transmission;single-cell RNA sequencing;skills;Standardization;Techniques;Time;Tissue-Specific Gene Expression;Training;transmission process;United States National Institutes of Health;Whole Blood;Work

PROJECT_TITLE: Investigating the molecular mechanisms of Plasmodium vivax invasion in Duffy-negative hosts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Patients with epilepsy who continue to have seizures while on medication can benefit from surgical removal of the brain region generating these seizures. This study aims to find imaging markers to locate the seizure- generating region. This could lead to higher success rates for these surgeries and a reduced need for invasive testing for these patients.

PI_NAMEs: SAINBURG, LUCAS  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Adopted;Biological Markers;Blood;Brain;Brain region;Clinical;cognitive testing;cohort;Data;Detection;Diagnostic tests;Drug resistance;Electrodes;Electroencephalography;Electrophysiology (science);Epilepsy;epileptiform;Equipment;Evaluation;Event;Excision;fluorodeoxyglucose positron emission tomography;Freedom;Functional Magnetic Resonance Imaging;Glucose;glucose metabolism;Goals;hemodynamics;Image;imaging biomarker;implantation;improved;Inpatients;insight;Intervention;Magnetic Resonance Imaging;Measures;Metabolic;Methodology;Methods;Modality;Modeling;Monitor;neuroimaging;non-invasive imaging;noninvasive diagnosis;novel;Operative Surgical Procedures;Outcome;Partial Epilepsies;Patients;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Physiology;Positron-Emission Tomography;Recurrence;Reporting;Research;Resolution;Rest;Scalp structure;Seizures;Sensitivity and Specificity;Series;Specificity;Structure;success;Techniques;Temporal Lobe Epilepsy;Testing;Time;tool;Treatment outcome;Work

PROJECT_TITLE: Seizure onset zone localization with functional MRI correlates of interictal physiology in temporal lobe epilepsy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: Aurora

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The goal of this project is to understand the molecular mechanisms coordinating epithelial cell polarization, apical lumen formation and ciliogenesis in kidney cells. During five previous funding cycles we have demonstrated that polarized endosome transport and cell division plays key roles in targeting proteins to the apical plasma membrane and identified the proteins that are required for this process. In this study we will identify the function and regulation of these polarity organizing proteins, as well as their role in apical lumen formation and ciliogenesis during normal kidney development and disease.

PI_NAMEs: PREKERIS, RYTIS  (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Address;Affect;alpha Tubulin;Apical;Biochemistry;Biological Assay;Body System;Cell division;Cell membrane;cell type;Cells;Cellular biology;Centrosome;Cilia;ciliopathy;cilium biogenesis;Code;Complex;Cystic kidney;Data;Defect;design;Development;Disease;Dissection;Docking;Endosomes;Epithelial Cells;Epithelium;Exhibits;Family;Funding;Genes;Genetic Diseases;Goals;Homeostasis;imaging approach;In Vitro;in vivo;in vivo Model;Kidney;kidney cell;Kidney Diseases;kinetosome;Lead;MDCK cell;Mediating;Methylation;Methyltransferase;Microscopy;Microtubules;Modeling;Modification;Molecular;Mutation;nephrogenesis;Organelles;Pathology;Play;polarized cell;Polycystic Kidney Diseases;polymerization;Polymers;Process;Protein Family;Proteins;Proteomics;Regulation;renal epithelium;Renal function;Role;Sensory;Signal Pathway;Signal Transduction;Site;Structure;Testing;tissue culture;tissue/cell culture;Tissues;Tubular formation;Tubulin;tyrosyltubulin ligase;Vertebrates;Work;Zebrafish

PROJECT_TITLE: Molecular Mechanisms Regulating Epithelial Cell Apical Polarity and Ciliogenesis

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Stimulant Use and Misuse;Substance Misuse;Women's Health Research

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Up to 90% of individuals who misuse cocaine also co-use alcohol [4, 5] and this co-use may vastly influence not only vulnerability to cocaine use but also maintenance of cocaine use and responsiveness to various behavioral and pharmacological treatments [7-9]. As a result, the research proposed in this application will examine all three aspects of drug misuse to determine how ethanol self-administration influences vulnerability to initial cocaine reinforcement, maintenance of cocaine self-administration in the presence of nondrug alternative reinforcers, and responsiveness to pharmacotherapies. Results from these studies should aid in the development of personalized medicine strategies for individuals who co-use cocaine and alcohol.

PI_NAMEs: ALLEN, MIA ISABEL (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Affect;Alcohol consumption;alcohol effect;Alcohols;analog;Animal Model;Behavior Therapy;Chemosensitization;Clinical;Clinical Research;clinical translation;Cocaine;Cocaine Abuse;Cocaine Dependence;Cocaine misuse;cocaine self-administration;cocaine use;Cocaine use disorder;Collaborations;Corpus striatum structure;cost;Data;design;Development;Dopamine;Dose;drug misuse;Ethanol;experience;FDA approved;Female;Food;Health;Individual;Intervention;Justice;Left;Macaca fascicularis;Maintenance;male;Modafinil;Modeling;Monkeys;multiple drug use;Naltrexone;National Research Service Awards;Nicotine;non-drug;nonhuman primate;novel;Opioid;Oral;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacological Treatment;Pharmacology Study;Pharmacotherapy;pre-clinical research;Predisposition;psychiatric comorbidity;Psychological reinforcement;Recording of previous events;reinforcer;Research;response;Schedule;Self Administration;sex;Substance abuse problem;substance use;Substance Use Disorder;System;Testing;Time;Treatment outcome

PROJECT_TITLE: The effect of ethanol self-administration on cocaine reinforcement in male and female monkeys


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Rare Diseases

ORG_CITY: DHAKA

ORG_COUNTRY: BANGLADESH

ORG_FIPS: BG

ORG_NAME: CHILD HEALTH RESEARCH FOUNDATION

PHR: Bacteriophages are viruses that infect bacteria, and in doing so, regulate their abundance, evolution, and virulence. In this project, we want to investigate bacteriophages that infect Salmonella Typhi, the causative agent of typhoid fever, and investigate their prevalence and genetic diversity in a setting where typhoid is endemic. We will also use genetic and biochemical tools to dissect the molecular mechanisms of the ongoing arms race between different strains of the Salmonella Typhi and its circulating bacteriophages.

PI_NAMEs: SAHA, SENJUTI  (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Admission activity;Antimicrobial Resistance;arms race;Bacteria;Bacteriophages;Bangladesh;biobank;Biochemical;biochemical tools;Bioinformatics;Biological Assay;Capital;Catchment Area;Cessation of life;Cities;Classification;climate change;Communicable Diseases;Communities;comparative;comparative genomics;Country;Detection;Development;Diagnostic;Drug resistance;Environment;Evolution;Exhibits;experience;extensive drug resistance;Feces;fitness;Food Contamination;Future;Gene Cluster;Genes;Genetic;Genetic Variation;Genomics;Genotype;Global Change;Hospitals;Human;improved;Infection;insight;Libraries;Life Cycle Stages;Link;Longitudinal, observational study;low and middle-income countries;Methods;Molecular;Multi-Drug Resistance;Mutagenesis;neglect;neglected tropical diseases;Nepal;Organism;Pakistan;Pathogenicity;Patients;Pediatric Hospitals;Play;Population;Predisposition;Prevalence;Public Health;Records;Research;Resistance;resistance mechanism;Role;Salmonella Phages;Salmonella typhi;Sewage;stool sample;surveillance network;surveillance study;System;Testing;Time;Travel;Typhoid Fever;Virulence;Virus;Water;water sampling;waterborne illness

PROJECT_TITLE: Investigating the dynamics of Salmonella Typhi and bacteriophages in the environment and the human gut

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SAS-W (J1)]


NIH_SPENDING_CATS: Bioengineering;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Current malaria vaccines are largely ineffective in individuals previously infected with Plasmodium, the causative agent of malaria, compared to Plasmodium-naïve individuals. The studies outlined in this proposal will both determine how prior Plasmodium infection impacts the humoral response to a subsequent vaccination and how to modify immunization techniques to overcome impaired immunity. These studies have the potential to impact how we approach vaccination of Plasmodium-experienced individuals.

PI_NAMEs: MCDOUGAL, COURTNEY  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Age;Antibodies;Antibody Response;Area;Avidity;B cell differentiation;B-Lymphocytes;Blood;burden of illness;Cells;Cessation of life;Child;circumsporozoite protein;circumsporozoite vaccine;Clinical;Clinical Trials;Data;Direct Repeats;Erythrocytes;experience;experimental study;Human;human model;Immune;Immune Evasion;Immune response;Immunity;Immunization;Immunize;Immunologic Memory;Impairment;imprint;improved;Individual;Infection;Length;Life;Life Cycle Stages;Liver;Malaria;Malaria Vaccines;Memory;Memory B-Lymphocyte;Modeling;mouse model;Mus;nanoparticle;novel;Parasites;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Plasmablast;Plasmodium;Population;Primary Infection;Proteins;Publishing;Repetitive Sequence;Research;response;Sampling;Shapes;Structure of germinal center of lymph node;Techniques;Tertiary Protein Structure;Testing;Tissues;transmission process;Vaccination;vaccination strategy;vaccine distribution;vaccine efficacy;vaccine response;Vaccines;vector control

PROJECT_TITLE: Understanding and overcoming Plasmodium-specific immune evasion mechanisms


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: BIOCHEMISTRY

PHR: Hydrogen sulfide regulates energy metabolism by functioning as a respiratory inhibitor and a substrate. Respiratory inhibition results from sulfide binding to the heme and copper centers of complex IV in the electron transport chain. This study will elucidate an unexpected connection between sulfide and cellular copper homeostasis that is relevant to the long-term effects of sulfide on energy metabolism.

PI_NAMEs: DIESSL, JUTTA  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: absorption;Acute;Address;Adenocarcinoma Cell;aerobic glycolysis;Affect;Affinity;Antimycin A;Atmosphere;ATP Synthesis Pathway;Binding;Biochemical;Bioenergetics;Biogenesis;Carbon Dioxide;carboxylation;Cardiovascular system;career development;Cell Line;Cell membrane;Cell Physiology;Cell Survival;Cells;Central Nervous System;Chronic;Colon;Colon Adenocarcinoma;Complex;complex IV;Copper;copper-binding protein;Couples;Cuprozinc Superoxide Dismutase;Cyanides;Data;Development;Down-Regulation;Electron Transport;Electron Transport Complex III;Electrons;Endosomes;Energy Metabolism;Enzymes;Epithelial Cells;Exhibits;Exposure to;Fluorescence Microscopy;Fluorescent Probes;gastrointestinal system;Golgi Apparatus;Growth;Heme;heme a3;HepG2;Homeostasis;HT29 Cells;Human Cell Line;Hydrogen Sulfide;Image;Immunofluorescence Microscopy;In Vitro;in vivo;Inductively Coupled Plasma Mass Spectrometry;inhibitor;insight;intestinal epithelium;Intestines;Isotopes;Kinetics;Laboratories;Lead;Lipids;Long-Term Effects;Measures;Mediating;Metabolic;Metabolism;Metals;microbial;Mitochondria;Mitochondrial DNA;Molecular;Molecular Chaperones;Monitor;mouse model;Mus;novel;oxidation;Oxidoreductase;Physiological;Physiological Processes;Positioning Attribute;Proliferating;Property;protein degradation;Protein-Lysine 6-Oxidase;Proteins;Quinones;Recovery;Regulation;Reporting;Research;Research Personnel;Research Training;Resolution;Respiration;respiratory;response;Roentgen Rays;Rotenone;Signaling Molecule;Site;skills;Specificity;Spectrometry;submicron;Sulfides;Sulfur;Sulfur Metabolism Pathway;Superoxide Dismutase;Synchrotrons;Testing;Thermodynamics;Tissues;Training;transcriptomics;Transformed Cell Line;Transition Elements;Ubiquinone;Vesicle;villin;Wilson disease protein;X-Ray Emission Spectrometry

PROJECT_TITLE: Sulfide-regulated copper metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences

ORG_CITY: Los Angeles

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative The proposed research examines the role of cochlear suppression in auditory processing of complex dynamic sounds that vary in sweep rate and direction (i.e., frequency sweeps). Key insights on the mechanisms of spatiotemporal processing have come from human behavioral masking experiments and direct physiological recordings in mammals using these stimuli, but cross-species differences and the invasive nature of physiological methods make it challenging to infer function in humans. By leveraging non-invasive otoacoustic and behavioral measures to study cochlear suppression and its dependence on sweep rate and direction, the proposed study will both improve our understanding of cochlear function important for human communication and provide a foundation for understanding how this might be affected by hearing impairment.

PI_NAMEs: SALLOOM, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TITLE: Human Cochlear Masking and Suppression Measured using Dynamic Stimuli

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Y (58)]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: PROJECT NARRATIVE No effective HIV vaccine has been developed to date due to major immunological barriers to elicit broadly neutralizing antibodies. The use of mRNA technology for HIV vaccines holds promise to conquer previous barriers through novel modalities of HIV antigen delivery. This proposal will test the elicitation of protective immune responses using novel HIV mRNA vaccines.

PI_NAMEs: RAMEZANI-RAD, PARHAM  (contact)

PROGRAM_OFFICER_NAME: MALASPINA, ANGELA

PROJECT_TERMS: Affinity;AIDS prevention;Animals;Antibodies;Antibody Formation;Antibody Response;Antigen Presentation;Antigens;Autologous;B-Lymphocytes;base;Binding;Biology;clinical development;Complex;COVID-19;COVID-19 vaccine;density;design;Dose;draining lymph node;Environment;Epitopes;Fine needle aspiration biopsy;HIV;HIV Antigens;HIV envelope protein;HIV vaccine;Human;Immune response;Immune signaling;Immunity;Immunization;Immunize;Immunobiology;immunogenic;Immunologic Memory;Immunologics;Immunology;improved;innovation;Intramuscular;Kinetics;Knowledge;Membrane;Memory;Modality;Mus;nanoparticle;Nature;neglect;neutralizing antibody;nonhuman primate;novel;Output;Phase;Preventive vaccine;Process;Proteins;Regimen;response;Route;Speed;Structure of germinal center of lymph node;Study models;subcutaneous;Technology;Testing;translational approach;vaccination strategy;vaccine platform;vaccine strategy;Vaccines;Virion;virus envelope;Virus-like particle;Work

PROJECT_TITLE: HIV mRNA vaccine strategies for efficient priming, diversity and durability of immune responses

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 BJM-A (J1)]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Communication between cortical areas is thought to occur via direct and transthalamic pathways. The specific functions(s) of each pathway and their relative contributions to cortical communication are important and unresolved questions. Given the severe financial and quality-of-life consequences that follow from disruption in cortical communication and thalamic processing, such as occurs with many forms of epilepsy and illnesses affecting vision, it is important that we understand how the thalamus and cortex interact to meet the processing needs of the brain.

PI_NAMEs: SHERMAN, S. MURRAY ;USREY, W MARTIN (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Abbreviations;Affect;Animal Model;Animals;Area;area striata;Behavior;Behavioral;behavioral response;Brain;cell cortex;Cell Nucleus;Cells;Communication;Complex;Data;density;design;designer receptors exclusively activated by designer drugs;Discrimination;discrimination task;Disease;Disparate;Dorsal;Epilepsy;Evolution;experimental study;extrastriate visual cortex;Functional disorder;gamma-Aminobutyric Acid;Genetic;Geniculate body structure;Glutamates;Goals;inferotemporal cortex;insight;Investigation;Lateral Geniculate Body;Lateral posterior nucleus of thalamus;Learning;Mammals;Medial;Mediating;Modeling;Monkeys;Movement;Mus;Neurons;optogenetics;Pathway interactions;Performance;Photic Stimulation;Population;Positioning Attribute;Primates;Process;Property;Pulvinar structure;Quality of life;Reporting;Research;response;Saccades;Short-Term Memory;Signal Transduction;somatosensory;Stroke;Structure;superior colliculus Corpora quadrigemina;Synapses;Testing;Thalamic Nuclei;Thalamic structure;tool;transmission process;V2 neuron;Vision;Visual;Visual Cortex;visual discrimination;Visual System

PROJECT_TITLE: Studies of direct and transthalamic pathways in visual cortex

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-A (02)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative A vaccine for HIV/AIDS is needed which can induce antibodies that protect against all strains of HIV. We will test a vaccine platform in monkeys that presents the whole HIV spike instead of part of the spike and combine it with state-of-the-art delivery and design approaches to elicit potent antibody responses against two key regions on HIV’s spikes.

PI_NAMEs: ZWICK, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: CHAKRABARTI, BIMAL KUMAR

PROJECT_TERMS: Adjuvant;Affinity;Animal Model;Antibodies;Antibody Response;Antibody-mediated protection;Antigens;Applications Grants;B-Lymphocytes;base;Binding;Binding Sites;Biological Assay;Cell Separation;Cessation of life;crosslink;design;Development;Directed Molecular Evolution;Disease;Enzyme-Linked Immunosorbent Assay;Genomics;Germ Cells;Germ Lines;Glycoproteins;glycosylation;HIV;HIV envelope protein;HIV vaccine;HIV/AIDS;Homologous Gene;Human;human model;Immunization;Immunize;Immunogenetics;Immunoglobulin Genes;Immunoglobulin Somatic Hypermutation;Infection;innovation;Knock-in Mouse;Length;Link;Liposomes;Macaca;Macaca mulatta;Maps;Membrane;Modeling;Monkeys;Monoclonal Antibodies;Mouse Strains;Mus;Mutagenesis;mutant;Mutation;nanoparticle;neutralizing antibody;next generation;nonhuman primate;novel;Oryctolagus cuniculus;Peptide antibodies;Peptides;Phase;Polishes;pre-clinical;Pre-Clinical Model;Protocols documentation;receptor;Regimen;Reporting;Reproducibility;response;Rodent;Serum;Site;Specificity;System;T cell response;Testing;USAID;Vaccine Design;vaccine development;vaccine platform;Vaccines;Variant;Virus;Work

PROJECT_TITLE: Leveraging membrane Env liposome vaccine design to elicit multi-target cross-neutralization of HIV

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: DUKE UNIVERSITY

PHR: RELEVANCE STATEMENT This study will examine the impact of a family-based intervention to reduce acculturative stress, promote resilience, and prevent behavioral and mental health problems among Latino immigrant parents and youth in the US. The findings from this study will inform multi-level interventions aimed at improving Latino health and well-being, the largest historically marginalized racial/ethnic group in the US.

PI_NAMEs: CERVANTES, RICHARD C;GONZALEZ-GUARDA, ROSA MARIA (contact)

PROGRAM_OFFICER_NAME: MARSHALL, VANESSA J

PROJECT_TERMS: Acculturation;Address;Adult;Affect;American;Anxiety;behavioral health;Binding;binge drinking;Child;cohesion;Communication;Communities;Community Health Aides;community organizations;Conflict (Psychology);Control Groups;coping;Data;Development;Dreams;Economic Conditions;effectiveness testing;efficacy evaluation;ethnic identity;Ethnic Origin;Ethnic Population;experience;Exposure to;Family;family support;follow-up;Generations;Goals;Health;health equity;health inequalities;Health Promotion;Health Resources;Health Services;Health Services Accessibility;high risk sexual behavior;HIV;HIV risk;Immigrant;Immigrant family;Immigration;improved;Individual;Influentials;Intervention;Interview;intimate partner violence;Latino;Linguistics;Maintenance;marginalization;marginalized community;marginalized population;Measures;Mediating;Mental Depression;Mental Health;Methods;Minority Groups;North Carolina;optimism;Outcome;parent-child communication;parental monitoring;Parents;Personal Satisfaction;physical conditioning;Pilot Projects;Population;prevent;Prevention;promote resilience;racial population;racism;Randomized;Randomized, Controlled Trials;Reporting;resilience;Resources;Risk;Risk Behaviors;Science;Services;Sexually Transmitted Diseases;social;social health determinants;Social Network;Social support;Social Work;socioeconomics;Source;Stress;stress resilience;stressor;Substance abuse problem;substance use;Surveys;syndemic;therapy design;Time;United States;Work;Youth

PROJECT_TITLE: SER Familia: A Family-Based Intervention Addressing Syndemic Conditions among Latino Immigrant Families

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: DURHAM VA MEDICAL CENTER

PHR: Significance: The proposed project could rapidly accelerate a promising new treatment for chronic complex TBI that is supported by strong preliminary data and builds upon compelling research findings. If allopregnanolone (ALLO) is efficacious and well-tolerated in this population, a larger Phase 2 or Phase 3 randomized controlled trial (RCT) would be the next logical step for this molecule - which has the potential to address an urgent unmet clinical need for Veterans with chronic complex TBI and commonly co-occurring conditions such as depression and pain symptoms, and to positively impact functional outcome and quality of life in this population. A longer-acting formulation of ALLO is also a possibility and under development in our laboratory. In the interim, the proposed pilot RCT using intravenous ALLO would provide critical pharmacokinetic data in this chronic complex TBI cohort, in addition to potential initial clinical signals for therapeutic efficacy and biomarker candidate identification to inform future efforts.

PI_NAMEs: MARX, CHRISTINE E. (contact)

PROJECT_TERMS: Acceleration;Address;Aftercare;Allopregnanolone;Analgesics;anti-depressive agents;Anti-Inflammatory Agents;antidepressant effect;Antiinflammatory Effect;arm;Behavior assessment;Biological Markers;Blood;Brain;Brief Pain Inventory;C-reactive protein;candidate identification;Chronic;Clinical;Clinical Data;clinical predictors;cohort;Complex;Cyclodextrins;cytokine;Data;depressive symptoms;Development;Dimensions;Dose;Drug Kinetics;efficacy evaluation;Electrocardiogram;Exhibits;Formulation;four-arm study;functional improvement;functional outcomes;Future;Goals;gray matter;Hamilton Rating Scale for Depression;heart rate variability;Hour;human data;improved;Inflammatory;inflammatory marker;Infusion procedures;Intervention;Intravenous;Laboratories;Magnetic Resonance Imaging;Mass Spectrum Analysis;Mental Depression;mild traumatic brain injury;Monitor;Musculoskeletal Pain;nanomolar;Neurobiology;neuroimaging;neuroprotection;neurosteroids;novel;Pain;Pain Disorder;pain symptom;Participant;Patients;Phase;Placebos;Population;pre-clinical;primary endpoint;Property;Quality of life;Randomized;Randomized, Controlled Trials;Recording of previous events;regenerative;regenerative therapy;Reporting;Research;Research Personnel;response;Rodent Model;secondary endpoint;Serum;SF-36;Signal Transduction;Symptoms;Therapeutic;therapeutic biomarker;therapeutic candidate;Thick;Treatment Efficacy;Veterans

PROJECT_TITLE: Novel Regenerative Therapeutic in Chronic Complex TBI

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cardiovascular;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN DIEGO

ORG_NAME: VALA SCIENCES, INC.

PHR: FDA guidelines stipulate that all new drugs be tested for dangerous side-effects on the heart as part of preclinical research; however, the current tests are poorly predictive of both dangerous and safe drugs leading to unwarranted attrition and dangerous drugs reaching clinic. Human cardiomyocytes derived from donor tissue (iPSC-derived cardiomyocytes) are widely considered to hold great promise for clinical trial in a dish studies of drug cardiotoxicity. This STTR proposal is to commercialize a high throughput platform to accurately identify drug candidates that have cardiac side effects, in particular adding the ability to detect the type of primary heart cell damage common with anti-cancer drugs in a fully automated (high throughput) robotic assay for the first time, to improve the efficiency of preclinical research and the safety of human clinical trials, which will also likely have the added benefit of reducing animal research.

PI_NAMEs: PRICE, JEFFREY H. (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Action Potentials;Address;Aging;American;Animal Experimentation;Animal Model;Animal Testing;Animals;anti-cancer therapeutic;Antineoplastic Agents;Arrhythmia;Artificial Intelligence;Biological Assay;Calcium;calcium indicator;cancer recurrence;cancer survival;Cancer Survivor;cancer therapy;cancer type;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiotoxicity;cardiovascular risk factor;Cardiovascular system;cell injury;Cell membrane;Cell Membrane Permeability;Cells;cellular imaging;Cessation of life;chemotherapy;Clinic;Clinical;clinical predictors;clinical trial in a dish;Clinical Trials;commercialization;Complex;compound 30;Contract Services;Contractile Proteins;cost;cytotoxicity;Dangerousness;detection assay;Development;dosage;Dose;drug candidate;drug development;drug discovery;Drug Industry;drug testing;Female;Fluorescence;Goals;Growth;Guidelines;Heart;heart cell;Heart Diseases;high throughput screening;Hour;Human;human induced pluripotent stem cells;Image;Image Cytometry;Impairment;improved;In Vitro;Incubated;induced pluripotent stem cell derived cardiomyocytes;insight;instrument;Kinetics;Label;Lead;lead series;male;Malignant Neoplasms;manufacture;manufacturing scale-up;Marketing;Measures;Methods;Microscopy;Mitochondria;Motion;Myocardium;Myopathy;novel therapeutics;Outcome;Pathologic;Performance;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Population;pre-clinical;Pre-Clinical Model;pre-clinical research;Production;Protocols documentation;Publications;Publishing;Quality Control;Recording of previous events;Recurrent tumor;Reporting;Research Contracts;response;Risk Assessment;Robotics;Safety;Sales;Sarcoplasmic Reticulum;scale up;Science;screening;screening services;Sensitivity and Specificity;side effect;Small Business Technology Transfer Research;Source;Specificity;Speed;System;Technology Transfer;Testing;Therapeutic;therapeutic candidate;Time;Tissue Donors;tool;Toxic effect;Treatment Side Effects;validation studies;voltage

PROJECT_TITLE: Combined Cardiomyopathy, e.g., of Cancer Chemotherapeutics, and Proarrhythmia for Cardiotoxicity Clinical Trials-in-a-Dish (CTiD) with iPSC-Derived Cardiomyocytes


ADMINISTERING_IC: HD

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The proposed project is a randomized control trial of a novel intervention for low-income mothers and fathers of infants using remote delivery to enhance parenting and coparenting. If efficacious, this program could be used alone or with other family-based services to improve parenting, co-parenting, and father engagement.

PI_NAMEs: RYAN, REBECCA MARIE (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Address;Affect;Architecture;Birth;Brain;Buffers;caregiving;Child;Child Development;Child Rearing;Childbirth;Cognitive;cognitive development;Communication;comparative efficacy;cost effective;Custom;design;Diagnostic;digital;digital media;dosage;early childhood;Education;efficacy evaluation;Emotional;Enhancement Technology;Evidence based intervention;Exclusion;experience;Family;Fathers;Feedback;Fostering;Foundations;Funding;Goals;Head Start Program;Home visitation;Hybrids;improved;Infant;innovation;innovative technologies;Intervention;Interview;Language Development;language outcome;Low income;lower income families;Magic;Manuals;Mediator;men;Mental Depression;Mental Health;Modality;Mothers;novel;Outcome;Parent-Child Relations;parenting intervention;Parents;Patient Self-Report;Persons;Pilot Projects;Poverty;preventive intervention;programs;Randomized;Randomized, Controlled Trials;recruit;rehearsal;remote delivery;Reporting;Research;retention rate;Schedule;secondary outcome;Services;sex;Shapes;skill acquisition;skills;stem;Stress;stressor;Tablets;Technology;Testing;Trust

PROJECT_TITLE: Connect to Baby: A Pilot Study of a Parenting and Coparenting Program for New Parents

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric

PHR: Project Narrative Visual processing in infancy is a critically important aspect of healthy development, and understanding typical development of visual processing has public health benefits. By furthering our knowledge about how cortical maturation and individual differences in experience shape the development of mature looking behaviors, this project will add significant knowledge about development in typical populations. Visual impairments in infants and children are increasingly caused by prenatal cerebral damage (e.g., cortical visual impairment) that impacts higher-level visual functions such as attention and processing of cluttered scenes (Ben Itzhak et al., 2019; Chang & Borchert, 2021; Hatton et al., 2007), and research like that proposed here will be essential for future assessment and intervention efforts.

PI_NAMEs: HUNTER, BRIANNA KEENAN (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Adult;Age;Attention;attentional control;Behavior;Behavioral;Brain;Brain region;California;career;Categories;cerebral visual impairment;Cerebrum;Child;Cities;Clinical;Clutterings;Complex;Computer Models;convolutional neural network;Development;Environment;Event;experience;experimental study;Exposure to;Eye;Eye Movements;Face;Familiarity;Future;gaze;Goals;Health Benefit;Home;Human;Image;Individual;Individual Differences;infancy;Infant;Infant Development;information gathering;innovation;insight;Instruction;Intervention;Knowledge;Learning;Life;Link;Mentorship;Methodology;Methods;Modeling;movement analysis;Neural Network Simulation;Parents;Pattern;Persons;Population;prenatal;Process;Property;Proxy;Public Health;Research;Role;sample fixation;Scanning;Shapes;skills;Stimulus;Supervision;Techniques;Testing;theories;Training;Universities;Variant;ventral visual stream;Vision;vision development;Visual;Visual attention;Visual impairment;visual processing;Visual System;visual tracking;Work

PROJECT_TITLE: Eye tracking and computational approaches to understand the roles of maturation and experience in infant looking


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Time restricted feeding (TRF) in a model of diet induced obesity (DIO) significantly reduced aortic damage and improved endothelial function. Th17 cells are an inflammatory CD4+ T cell subset that are upregulated in the aorta with DIO and reduced with TRF indicating a potential role of Th17 cells in mediating the reduced damage with TRF. The main goal of this project is to identify the mechanism of the role of Th17 cells in improved aortic damage and endothelial function with TRF in DIO.

PI_NAMEs: EDELL, CLAUDIA  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Acetylcholine;Adaptive Immune System;Affect;Anti-Inflammatory Agents;Antibodies;Aorta;Apolipoprotein E;Autoimmunity;Blood Vessels;Butyrates;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career;Cause of Death;CD4 Positive T Lymphocytes;Cells;Chronic;cytokine;Darkness;Data;Diet;diet-induced obesity;dietary;Dietary Assessment;Disodium Salt Nitroprusside;Eating;endothelial dysfunction;Endothelium;experimental study;Fasting;Fatty acid glycerol esters;feeding;Fellowship;Fibrosis;Flow Cytometry;Food;Functional disorder;Future;Goals;graduate school;Health;High Fat Diet;high risk;Histologic;Histology;Hour;Hypertension;Immune;Immune system;Immunoglobulin G;Immunology;Immunophenotyping;improved;Indirect Calorimetry;Inflammation;Inflammatory;Intake;interleukin-23;Interleukins;Intervention;Knockout Mice;Lesion;Light;Magnetic Resonance;Measurement;Measures;Mediating;Metabolic;Metabolic dysfunction;microbial;Modeling;mouse model;Mus;Obesity;Organ;Pathogenesis;Pathogenicity;Pathway interactions;Physiologic pulse;Physiology;Plasma;Population;pre-doctoral;Production;Propionates;Protocols documentation;PTPRC gene;receptor;Reducing diet;Regulation;Regulatory T-Lymphocyte;Research;Research Personnel;response;Risk Factors;Role;Scientist;single-cell RNA sequencing;skills;symposium;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Th1 Cells;Thick;Thinness;Time;Time-restricted feeding;Tissues;tool development;transcriptome sequencing;transcriptomics;United States;Vasodilation;Volatile Fatty Acids;Weight;Work

PROJECT_TITLE: Time Restricted Feeding in Diet Induced Obesity Improves Aortic Damage and Endothelial Function Through Reducing Th17 Cells


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PI: Kurshan, Peri T. Project Narrative  Mutations in synaptic cell-adhesion molecules such as neurexins are highly associated with neurodevelopmental and neuropsychiatric disorders and often lead to defects in synapse formation, although the molecular mechanisms by which this occurs are still largely unknown. In this proposal, we seek to understand the cell-intrinsic mechanisms by which presynaptic cell-adhesion molecules including neurexin are localized to synapses and contribute to their maturation. As a result, this research will have the potential to reveal novel therapeutic approaches to target diseases associated with defects in this critical class of synaptic proteins.

PI_NAMEs: KURSHAN, PERI T (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Actins;Address;Affect;Alleles;autism spectrum disorder;Axon;Binding;Biological;Biological Models;Biology;Brain;Caenorhabditis elegans;Cell Adhesion;Cell Adhesion Molecules;Cells;Cues;Cytoskeleton;Data;Defect;Dependence;Development;Disease;Disparate;extracellular;Functional disorder;Genetic;genetic approach;Goals;Growth Cones;imaging approach;In Vitro;in vivo;information processing;innovation;Integral Membrane Protein;Intellectual functioning disability;Kidney;Kinesin;Knowledge;Mammals;Mediating;Modeling;Molecular;Molecular Motors;Motor;mutant;Mutation;Nematoda;nephrin;Nervous System;neural circuit;Neurodevelopmental Disorder;neuronal circuitry;neuropsychiatric disorder;new therapeutic target;novel therapeutic intervention;Optics;Phase;Physical condensation;podocyte;polymerization;Polymers;Positioning Attribute;preservation;presynaptic;Process;programs;Protein Biosynthesis;Protein Isoforms;protein transport;Proteins;Publishing;Recording of previous events;recruit;Research;Role;scaffold;Scaffolding Protein;Schizophrenia;Signal Transduction;Site;Stereotyping;Synapses;Synaptic Cleft;synaptic function;synaptogenesis;System;Testing;Therapeutic Intervention;trafficking;Translations;Vesicle

PROJECT_TITLE: Cell-intrinsic mechanisms of presynaptic assembly

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: CHARLESTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative Regionalized myocardial fibrosis is commonly observed in patients with mitral valve prolapse (MVP), and is a risk factor for postoperative left ventricular dysfunction as well as sudden cardiac death. The proposed studies aim to demonstrate a mechanistic link between a prolapsing mitral valve and abnormal mechanical forces that promote regionalized myocardial fibrosis, and will further dissect the cellular, mechanical, and molecular changes that initiate and sustain regionalized myocardial fibrosis in MVP. Completion of this proposal will identify new biological pathways that can be targeted for patient benefit, and lend support for modification of existing surgical guidelines to minimize sudden death and postoperative dysfunction in these patients.

PI_NAMEs: MORNINGSTAR, JORDAN E. (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Adherence;Affect;American;Animal Model;Aorta;Apical;ATAC-seq;Automobile Driving;Autopsy;Benign;Biological;Biopsy;Bioreactors;Cardiac;Cardiac Death;Cardiovascular system;cell type;Cells;Cellular Assay;Cessation of life;Clinical;clinical training;Collagen;Connexin 43;coronary fibrosis;Data;Data Set;Deposition;Development;Disease;Dose;early screening;Echocardiography;experience;Failure;Family;Fellowship;Fibroblasts;fibrogenesis;Fibrosis;Functional disorder;Gadolinium;Genetic;Genetic Transcription;Genomic Segment;Genomics;Germ Lines;Goals;Guidelines;Heart;Human;human model;imaging study;in vitro Assay;in vivo;Incidence;Individual;insight;Knowledge;Left;Left atrial structure;Left Ventricular Dysfunction;Left ventricular structure;Link;loss of function;Magnetic Resonance Imaging;mechanical force;Mechanical Stress;Mechanics;Mitral Valve;Mitral Valve Insufficiency;Mitral Valve Prolapse;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;mouse model;Mutation;Myocardial;Myocardium;Operative Surgical Procedures;papillary muscle;Pathogenicity;Pathologic;Pathway interactions;Patients;Pattern;pharmacologic;Physicians;Postoperative Period;pre-doctoral;prevent;Process;programs;Ptosis;repaired;Reporter;Research;Research Training;response;Risk Factors;Role;routine screening;Sampling;Scientist;Signal Transduction;Stimulus;Stress;Stretching;Structure of chordae tendineae cordis;success;sudden cardiac death;Sudden Death;Surgical Management;Systole;Testing;Therapeutic;Time;Traction;transcriptome sequencing;transcriptomics;Translating;United States;Ventricular;Work

PROJECT_TITLE: Mechanisms of Left Ventricular Fibrosis in Mitral Valve Prolapse


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Vaccine Related

ORG_CITY: COLLEGE PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). Despite growing evidence that T cells play a vital role in combatting COVID- 19, very little structural information is currently available on the interaction of SARS-CoV-2-specific T cell receptors (TCRs) with their peptide–MHC (pMHC) targets. We propose to address this knowledge gap by using X-ray crystallography to determine three-dimensional structures of TCRs from COVID-19 convalescent patients bound to selected SARS-CoV-2 T cell epitopes and HLA-A2 or HLA-B7.

PI_NAMEs: MARIUZZA, ROY A (contact);PIERCE, BRIAN G.

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Address;Agammaglobulinemia;Antibodies;Antibody Response;B-Lymphocytes;Binding;CD8-Positive T-Lymphocytes;Cellular Immunity;Complex;computerized tools;Coronavirus;COVID-19;COVID-19 pandemic;COVID-19 vaccine;cross reactivity;cytotoxic CD8 T cells;Databases;Deposition;design;Disease;Epitopes;experience;Generations;Genes;Goals;Grant;HLA-A gene;HLA-A2 Antigen;HLA-B Antigens;HLA-B7 Antigen;Immune;Immunity;Immunologic Surveillance;Individual;Infection;Influenza A virus;insight;Knowledge;long term memory;Lymphopenia;Mediating;MHC Class I Genes;Modeling;Molecular;molecular sequence database;Mutagenesis;Mutation;neutralizing antibody;novel;Nucleocapsid;Patients;Peptide/MHC Complex;Pharmacologic Substance;Play;Privatization;receptor binding;Recovery;Resolution;Respiratory syncytial virus;Respiratory System;response;Risk Assessment;Roentgen Rays;Role;SARS-CoV-2 antibody;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Severity of illness;structural biology;Structure;T cell response;T memory cell;T-Cell Activation;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;three dimensional structure;Time;tool;universal coronavirus vaccine;Vaccine Design;vaccine efficacy;Variant;Viral;Viral Respiratory Tract Infection;Virus;X-Ray Crystallography

PROJECT_TITLE: Structural Basis for T Cell Recognition of SARS-CoV-2

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-S(02)]


ORG_CITY: TAMPA

ORG_NAME: JAMES A. HALEY VA MEDICAL CENTER

PHR: Traumatic brain injury (TBI) is one of the leading causes of death and disability in the USA, where nearly 2 million individuals are diagnosed with TBI each year. Survivors of TBI experience life long disabilities which can signiﬁcantly affect their quality of life and productivity. Mild brain injuries remain difﬁcult to diagnose given the overlap in their clinical presentation with other conditions. In addition, individuals with TBI are at high risk of developing Alzheimer's disease (AD), particularly among genetically predisposed individuals with the apolipoprotein E (APOE) ε4 allele. As such, there remains a critical need for availability of non-invasive blood markers that can help diagnose and identify underlying pathology that may be indicative of their future risk of developing AD. The work proposed will apply state of the art mass spectrometry technology to identify blood lipid metabolites as biomarkers of TBI.

PI_NAMEs: ABDULLAH, LAILA  (contact);CRAWFORD, FIONA C.

PROJECT_TERMS: accurate diagnosis;Affect;Afghanistan;Alleles;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Apolipoprotein E;Apolipoproteins;biobank;Biological;Biological Assay;Biological Markers;biomarker identification;biomarker panel;Blood;blood lipid;Brain Injuries;brain tissue;candidate marker;Caring;Cause of Death;Ceramides;Chronic;Clinical;Cognition;Cognitive;Cognitive deficits;cohort;Collection;comorbidity;comparison control;Development;Diagnosis;Diagnostic;Diet;disability;Disease Management;Eicosanoids;Enrollment;Exhibits;experience;Fasting;follow-up;Freedom;Functional disorder;Future;Generations;Genetic Predisposition to Disease;Genotype;Glycerol;healthy volunteer;High Pressure Liquid Chromatography;high risk;Homeostasis;Hospitals;Hybrids;Immune response;Impaired cognition;improved;Individual;Inflammation;Inflammatory;Inflammatory Response;Injury;Iraq;Isoprostanes;Learning;Life;Life Experience;lipidomics;Lipids;Lipoxins;Longitudinal Studies;Manufactured football;mass spectrometer;Mass Spectrum Analysis;Memory;Memory impairment;Memory Loss;mild cognitive impairment;mild traumatic brain injury;Military Personnel;military veteran;nano;Nature;Nerve Degeneration;Nervous System Trauma;Neurocognitive Deficit;neuropathology;novel;Omega-3 Fatty Acids;Omega-6 Fatty Acids;operation;Outcome;Oxidative Stress;Pathogenesis;Pathology;Patients;Persons;Phospholipids;Plasma;Polyunsaturated Fatty Acids;Population;Post-Traumatic Stress Disorders;pre-clinical;Predictive Value;Process;Productivity;Prognosis;Quality of life;Resolution;Risk;Role;Sampling;Scientist;Series;Site;Soldier;Sphingomyelins;Sphingosine;sphingosine 1-phosphate;Survivors;Symptoms;System;tau Proteins;TBI Patients;Technology;Testing;Time;Tissues;Traumatic Brain Injury;ultra high pressure;Variant;War;Work

PROJECT_TITLE: Identifying APOE related lipid biomarkers for diagnosing chronic neurocognitive deficits in TBI patients


NIH_SPENDING_CATS: Genetics;Human Genome;Obesity

ORG_CITY: LOS ANGELES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The prevalence of obesogenic cardiometabolic disorders (CMDs) is increasing alarmingly worldwide. Previous large-scale genome-wide association studies (GWAS) have reliably identified CMD-associated variants; however, their cell-type-specific mechanisms have remained largely elusive. To address this scientific knowledge gap and further our understanding of gene expression at a single cell level, we will perform single nucleus RNA-sequencing in 300 subcutaneous adipose tissue samples to generate fine-scale estimates of cell-type proportions; identify study-wide and personalized cell-type-specific differences corresponding to cardiometabolic trait levels; and characterize GWAS variants that underlie CMDs by altering cell-type-specific expression.

PI_NAMEs: MOHLKE, KAREN L.;PAJUKANTA, PAIVI  (contact);SCOTT, LAURA J.

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Affect;Alleles;Automobile Driving;Biological;Biopsy;Biopsy Specimen;Cardiometabolic Disease;cardiometabolism;Cell Nucleus;Cell Physiology;cell type;Cells;cohort;Communities;Data;data repository;Data Set;Detection;Disease;disorder prevention;disorder risk;Endocrine;Exhibits;experience;Female;Freezing;Gene Expression;Genes;Genetic;Genetic Transcription;genetic variant;genome wide association study;genome-wide;genome-wide analysis;Health;Heterogeneity;Human;Hypertension;Hypertriglyceridemia;improved;Individual;Knowledge;Medical History;Metabolic;multiple omics;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Obesity Epidemic;obesogenic;Outcome;Phenotype;phenotypic data;Population;Population Heterogeneity;Predisposition;Prevalence;Quantitative Trait Loci;Research;Resolution;Resources;RNA Sequences;Sampling;Sex Differences;Signal Transduction;single nucleus RNA-sequencing;Specificity;subcutaneous;success;Testing;Tissue Sample;Tissues;trait;transcriptomics;Validation;Variant

PROJECT_TITLE: Genetics of adipose cell-type expression and cardiometabolic traits

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Human endogenous retroviruses (HERVs) are remnants of retroviruses that were integrated into human genome millions of years ago. Although HERVs are generally suppressed in the current human cells, we found that LTR5_Hs, a special HERV species that is found only in the genome of humans but not monkeys, is uniquely activated in early-stage gamete precursor cells, which release retrovirus-like particles from their surface. This project will attempt to determine possible roles of LTR5_Hs in development of the human gamete precursor cells, testing a hypothesis that production of sperm and eggs in the normal human body is dependent on reactivation of this otherwise suppressed viral DNA.

PI_NAMEs: SHIODA, TOSHIHIRO  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: access restrictions;Antigens;Cell Culture Techniques;Cell Differentiation process;Cell membrane;cell type;Cells;Cellular biology;Characteristics;Chimeric Proteins;CRISPR interference;Data;deep sequencing;demethylation;Development;DNA;egg;Electron Microscopy;Elements;Embryo;embryo cell;Endogenous Retroviruses;Engineering;Enhancers;Epigenetic Process;epigenome;Ethics;Excision;experimental study;Fluorescence;Generations;Genes;Genetic Heterogeneity;Genetic Materials;Genetic Transcription;Genome;Genomics;Germ Cells;Germ Layers;Germ Lines;Guide RNA;Health;Hi-C;high risk population;Human;Human body;Human Development;Human Genome;human induced pluripotent stem cells;human migration;human pluripotent stem cell;Immunofluorescence Immunologic;In Vitro;Individual;Infertility;Inherited;insight;Knowledge;Label;Laboratories;Life Cycle Stages;Literature;Macaca;male;Microfluidic Microchips;Microfluidics;Modeling;Monkeys;Monoclonal Antibodies;novel;Oligonucleotides;Organoids;Outcome;particle;Peptides;Physiological;Play;pluripotency;Pluripotent Stem Cells;Population;precursor cell;Pregnancy;Preparation;Production;Proteins;Protocols documentation;reconstitution;Reproduction;Reproductive Biology;Retroviridae;RNA;RNA-Directed DNA Polymerase;Rodent;Role;senescence;Serum;single-cell RNA sequencing;Somatic Cell;sperm cell;Stains;Structure of primordial sex cell;success;Surface;System;Testing;Testis;three dimensional structure;transcriptome;transcriptome sequencing;vector;Vesicular stomatitis Indiana virus;Viral;viral DNA;Viral Envelope Proteins;Virus-like particle

PROJECT_TITLE: Roles of the LTR5_Hs human-specific endogenous retroviruses in primordial germ cells

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The proposed research is relevant to public health because understanding the extent to which cognitive training is susceptible to placebo effects, and if so, whether such effects can be magnified/harnessed, would greatly aid the development and evaluation of treatment regimens for a host of disorders where deficits in cognitive function are amongst the core symptoms (e.g., ADRD in particular, as related to older adults, but also ADHD, schizophrenia, TBI, MCI, etc.). Thus, the proposed research cuts across the bounds of numerous NIH agencies, contributing to the missions of the NIA, NCI, NEI, NIMH, NIAAA, NINCD, NIDA, NINDS, in that all of these agencies work with populations who can gain direct benefits from successful approaches to mental fitness, and the NIH's greater mission to seek knowledge that will result enhanced health and a reduced burden of disabilities.

PI_NAMEs: GREEN, CHRISTOPHER S (contact);JAEGGI, SUSANNE M;SEITZ, AARON R

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Address;Adult;Age;age group;Age-associated memory impairment;Alzheimer's disease related dementia;Applied Research;Association Learning;Attention deficit hyperactivity disorder;attentional control;Automobile Driving;Basic Science;Belief;Benchmarking;Binding;blind;Blinded;Characteristics;Cognition;Cognitive;cognitive ability;cognitive benefits;cognitive enhancement;cognitive function;cognitive process;cognitive task;cognitive training;cohort;Critiques;Data;Data Set;design;Development;disability burden;Disease;Drug Controls;effective intervention;Evaluation;expectation;experience;fitness;flexibility;Foundations;Funding;Future;Health;Heterogeneity;improved;Individual;Individual Differences;Industry;Intelligence;Intervention;Journals;Knowledge;learning strategy;Liquid substance;Manuscripts;Marketing;Measures;Methods;middle age;Mission;National Institute of Drug Abuse;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;National Institute on Alcohol Abuse and Alcoholism;older adult;optimism;Outcome;Outcome Measure;Participant;Performance;Personality;Personality Traits;Persons;Pharmacologic Substance;Placebo Effect;Placebos;Play;Population;Predisposition;prevent;Process;Production;Protocols documentation;Psyche structure;Public Health;Published Comment;Research;Research Design;Research Personnel;Research Project Grants;research study;Risk;Role;Route;Running;Sample Size;Schizophrenia;selective attention;Short-Term Memory;Site;Solid;stem;Suggestion;Symptoms;Task Performances;Testing;Training;trait;Translating;Translational Regulation;Treatment Protocols;United States National Institutes of Health;verbal;Work;young adult

PROJECT_TITLE: Examining the contributions of placebo effects in cognitive training


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Pain Research;Palliative Care;Rare Diseases

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Patients with chronic, life-limiting illness and acute respiratory failure are at high risk for poor patient- and family-centered outcomes and represent a patient population in need of high-quality palliative care. This project will address our limited knowledge regarding palliative care for these patients and their family members by examining temporal trends in quality indicators of palliative care. Knowledge gained from this study will guide future research to improve palliative care delivery and outcomes for patients with acute respiratory failure and their family members.

PI_NAMEs: NOMITCH, JAMIE TREADWAY (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute respiratory failure;Adult;Biostatistical Methods;care delivery;care outcomes;Caring;Chronic;Chronic Disease;Chronically Ill;Clinical;cohort;Communication;Consensus;Consultations;COVID-19;COVID-19 pandemic;COVID-19 patient;current pandemic;Data;data platform;effective intervention;Electronic Health Record;Emotional;end of life care;Epidemiologic Methods;Evolution;experience;Face;Family;Family member;Funding;Goals;Healthcare Systems;high risk;Home;Hospital Mortality;hospital readmission;Hospitalization;Hospitals;improved;Intervention;Knowledge;Life;Malignant Neoplasms;Measurable;Mechanical ventilation;medical specialties;Mentors;Mentorship;Morbidity - disease rate;mortality;mortality risk;National Heart, Lung, and Blood Institute;Outcome;Outcomes Research;Pain Measurement;Palliative Care;pandemic disease;Patient Care;patient population;Patient-Focused Outcomes;Patients;Pattern;physical symptom;Physicians;Population;post-pandemic;pre-pandemic;primary outcome;Process;psychologic;Publications;Quality Indicator;Quality of life;Records;Research;Research Personnel;Respiratory Failure;skill acquisition;Spirituality;Stress;Structure;Survivors;Symptoms;therapy design;Time;Time trend;trend;United States;United States National Institutes of Health

PROJECT_TITLE: Temporal trends in quality indicators of palliative care for patients with chronic illness hospitalized with acute respiratory failure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: PROJECT NARRATIVE – OVERALL The Partnership to Assess Viral and Immune Landscape Intersections with Oncology for People Living with HIV Program (PAVILION) will bring together experienced research sites and world-renowned HIV, human papillomavirus, Epstein Barr Virus, and cancer researchers to offer a novel contribution to the HIV-Associated Malignancies Research Center network. The PAVILION theme is research of understudied, virus-associated tumors that disproportionately impact men and women living with HIV in sub-Saharan Africa with the overall goal of providing the data necessary to inform prevention and therapeutic strategies to reduce the burden of cancers among people living with HIV and cancer in this region. This partnership will directly address the urgent need to mitigate a rapidly rising cancer burden that is largely comprised of infection-associated cancers in two partnering low- and middle-income countries (South Africa and Zimbabwe) that have among the highest prevalence of HIV infection in Africa.

PI_NAMEs: BOROK, MARGARET ZIONA;BOTHA, MATTHYS HENDRIK;GIULIANO, ANNA R. (contact)

PROGRAM_OFFICER_NAME: KALEEBA, JOHNAN AUGUSTINE

PROJECT_TERMS: Address;Africa;Africa South of the Sahara;AIDS related cancer;Anatomy;anti-cancer research;antiretroviral therapy;Award;Cancer Burden;Cancer Control;Cancer Etiology;cancer risk;cancer therapy;Cervical;Clinical;co-infection;Collaborations;comorbidity;Conjunctival Neoplasms;Conjunctival Squamous Cell Carcinoma;Country;Data;data management;design;Detection;Development;Disease;Educational workshop;Etiology;experience;Faculty;Fostering;Future;Germany;Goals;High Prevalence;high risk;HIV;HIV Infections;HIV/AIDS;Home;HPV screening;Human Herpesvirus 4;Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immune;Immunosuppression;improved outcome;Infection;infection related cancer;Infrastructure;innovation;Institution;Intervention;Laboratories;Lead;Leadership;leadership development;lectures;Life;Life Expectancy;Longitudinal Studies;low and middle-income countries;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant neoplasm of penis;Malignant neoplasm of vulva;Malignant Neoplasms;malignant oropharynx neoplasm;Medical;men;Mentors;Mentorship;Morbidity - disease rate;mortality;novel;Oncogenic Viruses;Oncology;Outcome;Persons;Pilot Projects;Premature Mortality;prevent;Prevention;Productivity;programs;Research;Research Infrastructure;Research Personnel;Research Training;Resources;Role;Site;South Africa;statistics;success;Sustainable Development;targeted treatment;Therapeutic;Training Programs;Translations;Treatment outcome;tumor;tumor-immune system interactions;United States National Institutes of Health;Viral;Virus;virus related cancer;Woman;Zimbabwe

PROJECT_TITLE: Partnership to Assess Viral and Immune Landscape Intersections with ONcology for People Living with HIV (PAVILION)


NIH_SPENDING_CATS: Cancer;Clinical Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention

PHR: PROJECT NARRATIVE – ADMINISTRATIVE & COORDINATING CORE The Administrative & Coordinating (AC) Core for the P artnership to A ssess V iral and Immune L andscape Intersections with cology for People Living with HIV (PAVILION) is the backbone of this U54 research center and is essential for ensuring the short- and long-term success of the team by providing overall scientific leadership and operational and financial oversight of the partnership. Further, the AC Core is responsible for ensuring clear lines of communication within the partnership, overall scientific rigor and reproducibility through a robust Protocol Development & Implementation Team and planning and evaluation activities including consultation from the External Advisory Panel and the national HIV-Associated Malignancy Research Center (HAMRC) network. ON

PI_NAMEs: GIULIANO, ANNA R. (contact)

PROJECT_TERMS: Address;AIDS related cancer;Area;Award;Budgets;Cancer Center;career;Clinical Services;Communication;Communities;community advisory board;conflict resolution;Consult;Consultations;Country;Decision Making;Development;Ensure;Evaluation;experience;Funding;Future;global health;Goals;Health Policy;HIV;Immune;Individual;Information Dissemination;interest;International;international partnership;Leadership;low and middle-income countries;Maintenance;member;Mentors;Oncology;Persons;Pilot Projects;prevention service;Principal Investigator;programs;Progress Reports;protocol development;Protocols documentation;Reporting;Reproducibility;Research;Research Personnel;Resource Sharing;screening services;Site;skills;South Africa;success;training opportunity;Translating;Translations;treatment services;United States National Institutes of Health;Vertebral column;Viral;Work;Zimbabwe

PROJECT_TITLE: Administration & Coordinating Core


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE The Na-Cl cotransporter in the distal nephron is a major component of Na+ homeostasis and its dysregulation leads to salt wasting or increased blood pressure. The transporter is also highly responsive to changes in plasma K+ through a cascade of kinases which function is tightly regulated. This application describes studies designed to provide new insights into the roles of KS-WNK, Cab39, and Sall3 in modulating this kinase- mediated regulatory pathway.

PI_NAMEs: DELPIRE, ERIC J (contact);WELLING, PAUL A

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: absorption;Adaptor Signaling Protein;base;Binding;blood pressure elevation;blood pressure reduction;Cellular biology;Coin;Consumption;cullin-3;Data;Diet;Dietary Potassium;dietary salt;Distal;Distal convoluted renal tubule structure;Drops;Engineering;Epigenetic Process;Equilibrium;familial hyperkalemic hypertension;Famines;Fingerprint;Fire - disasters;Funding;gene network;gene repression;Genetic;Genetic Transcription;Genomics;Gitelman syndrome;Goals;Gordon syndrome;Homeostasis;Hyperplasia;Hypertrophy;Hypokalemia;Image;imaging approach;In Vitro;inhibitor;innovation;insight;Intake;interdisciplinary approach;Kidney;Knock-out;knockout gene;Knockout Mice;loss of function mutation;Mediating;Membrane;Methylation;Modeling;Modernization;Molecular;Molecular Genetics;mouse model;Mus;Mutation;Nephrons;novel;Online Mendelian Inheritance In Man;Pathway interactions;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Physiology;Plasma;Potassium;Potassium Channel;Protein Dephosphorylation;Protein Isoforms;Protein phosphatase;Proteins;Publishing;Regulatory Pathway;Research Design;response;Role;salt sensitive hypertension;scaffold;Shapes;Signal Pathway;Signal Transduction;SLC12A3 gene;Sodium;Sodium Chloride;Structure;symporter;System;Testing;Time;Transcript;transcription factor;Transcription Factor 3;transcriptome sequencing;Type II Pseudohypoaldosteronism;Ubiquitination;wasting;western diet

PROJECT_TITLE: WNK-SPAK signaling in the Distal Nephron

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P(03)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Public Health Relevance Statement (Program Narrative): “This training program is specifically designed to train a new cadre of researchers and leaders to address major but under-studied public health problems arising from conditions prevalent in urban and rural communities in low- and middle-income countries (LMIC). This training is relevant also to developed countries as populations face increasing barriers to stable housing and healthcare. Selected candidates will undergo field training on site in LMICs to develop new global health research skills framed within our project research theme of strengthening health systems.

PI_NAMEs: BARRY, MICHELE ;HARRIS, EVA ;KO, ALBERT ICKSANG (contact);MADHIVANAN, PURNIMA

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: Address;Africa;Arizona;Asia;California;career;Career Choice;career development;Caribbean region;Central America;Collaborations;Communicable Diseases;Communities;Country;Dedications;design;Discipline;Disease;doctoral student;Eastern Europe;Educational workshop;Environmental Health;Exposure to;Faculty;faculty mentor;global health;Health;health equity;Health equity research;HIV;Human;Inequity;Injury;Institution;Interpersonal Violence;low and middle-income countries;member;Mental Health;Mentors;Mentorship;Methods;multidisciplinary;Persons;Postdoctoral Fellow;pre-doctoral;programs;recruit;Research;Research Methodology;Research Personnel;Research Support;Research Training;Rural;Scholars Program;Site;Slum;South America;Substance abuse problem;Supervision;Time;Training;Training Programs;Universities;Vulnerable Populations;Women's Health;Work

PROJECT_TITLE: Global Health Emerging Scholars Program


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

PHR: PROJECT NARRATIVE – PROJECT 1 People living with HIV (PLWH) have significantly higher cancer incidence compared to people without HIV for cancers caused by HPV (cervical, vulvar, anal, penile, and oropharyngeal), and altered immunity, not simply immunodeficiency, is one proposed mechanism driving this excess risk. The tumor viral and immune milieu are likely major factors contributing to these cancer disparities among PLWH, but few studies have examined the factors (viral and immune) that underlie differences in the cancer burden by HIV status, which is critical information needed to develop improved cancer prevention and treatment strategies for PLWH. Project 1’s overall goal is to inform the development of effective prevention and treatment strategies for HPV-related cancers among PLWH in SSA through thorough investigation of the viral and tumor immune factors associated with HPV- cancers and treatment outcomes using viral and immune profiling tools and high-dimensional technologies.

PI_NAMEs: BOTHA, MATTHYS HENDRIK (contact)

PROJECT_TERMS: Africa South of the Sahara;Age;Anus;Automobile Driving;biobank;biological sex;Cancer Burden;cancer care;cancer diagnosis;Cancer Etiology;cancer health disparity;cancer prevention;cancer therapy;CD3 Antigens;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cervical;chemoradiation;Clinical;co-infection;cohort;Country;CTLA4 gene;Development;DNA;Enrollment;Environment;Etiology;Exclusion;exhaust;exhaustion;FOXP3 gene;Frequencies;Future;Genetic Transcription;Genotype;Goals;Grouping;high dimensionality;HIV;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immune;immune cell infiltrate;Immunity;immunodeficiency;Immunologic Factors;Immunotherapy;improved;Incidence;Individual;Infiltration;Infrastructure;innovation;Investigation;Laboratories;low and middle-income countries;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant neoplasm of penis;Malignant neoplasm of vulva;Malignant Neoplasms;malignant oropharynx neoplasm;Medical;men;Methods;mortality;novel strategies;Oncogenic;Oncology;Oropharyngeal;Outcome;Participant;Patients;Pattern;penis;Persons;Pilot Projects;Population;Population Attributable Risks;Prevalence;Prevention strategy;programmed cell death ligand 1;programmed cell death protein 1;Research;Risk;RNA;screening;Screening for cancer;Site;Spatial Distribution;Specimen;survival outcome;T-Lymphocyte;Technology;Testing;Time;Tissues;tool;Treatment outcome;treatment strategy;tumor;tumor microenvironment;Tumor-infiltrating immune cells;understudied cancer;Viral;Vital Status;Vulva;Woman

PROJECT_TITLE: Project 1: Exploring viral and immunological factors of HPV associated cancers in PLWH and its relation to survival


NIH_SPENDING_CATS: Genetics

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative- Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand sensitive nuclear receptor which functions as a master regulator of adipogenesis and has broad relevance in metabolic syndrome and type 2 diabetes. Transcriptionally activating PPARγ ligands that bind to a C-terminal structured ligand- binding domain promote insulin sensitization and have been used clinically for type 2 diabetes treatment; however, it remains poorly understood how the N-terminal intrinsically disordered AF1 region of PPARγ regulates nuclear receptor activity on a structural level. In this project I will use structural methods well suited for studying disordered proteins along with cellular studies to gain insight into how the AF1 region interacts with protein binding partners in a post translational modification-dependent fashion to tune PPARγ cellular functions.

PI_NAMEs: WILLIAMS, CHRISTOPHER CONRAD (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: 3-Dimensional;adipocyte differentiation;Adipocytes;Affect;Affinity;Agonist;antagonist;Automobile Driving;Binding;Binding Proteins;Binding Sites;Biological Assay;Biology;biophysical techniques;C-terminal;Cell Physiology;Cells;Clinical;Complex;crosslink;Cryoelectron Microscopy;Data;Data Correlations;Diabetes Mellitus;Disease;DNA Binding Domain;Enzymes;Epitopes;experimental study;FDA approved;flexibility;Gene Expression Profiling;Genes;genetic corepressor;Genetic Transcription;Glean;Human;In Vitro;insight;Insulin;insulin sensitivity;Interferometry;Isomerase;Isomerism;Isotope Labeling;Kinetics;knock-down;Label;Length;Ligand Binding;Ligand Binding Domain;Ligands;lipid biosynthesis;Lipolysis;MAPK1 gene;Mass Spectrum Analysis;Measures;Mediating;Mediator;Metabolic syndrome;Methods;Modeling;Molecular;Molecular Conformation;Monitor;Mutagenesis;N-terminal;NIMA;NMR Spectroscopy;Non-Insulin-Dependent Diabetes Mellitus;Nuclear Magnetic Resonance;Nuclear Protein;Nuclear Receptors;overexpression;Pattern;Peptides;Peptidylprolyl Isomerase;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Plasmids;Population;Post-Translational Protein Processing;PPAR gamma;programs;Proline;Protein Conformation;Protein Region;Proteins;Proteomics;Rationalization;recruit;Regulation;Reporter;Role;Site;small hairpin RNA;structural biology;Structure;Tertiary Protein Structure;Therapeutic;tool;transcription factor;Vertebral column;Visualization;X-Ray Crystallography

PROJECT_TITLE: Molecular mechanism of PIN1-mediated regulation of the nuclear receptor PPARy