NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Eye Disease and Disorders of Vision;Mental Health;Neurosciences;Pediatric

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Early adolescence represents a time in which many youth first join social media. This use may occur in concert with negative changes in body image perceptions, which social media is also known to detrimentally influence. This study will examine bidirectional, longitudinal linkages between early adolescent social media use and body image concerns, with a special focus on the role of parents and an emphasis on self-focused visual attention biases to digital content.

PI_NAMEs: BURNELL, KAITLYN  (contact);TELZER, EVA HAIMO

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Adolescence;Adolescent;Adolescent Development;Adult;Affect;Age;Appearance;Attention;attentional bias;Attitude;Behavior;body dissatisfaction;Body Image;boys;Child;Child Rearing;Code;Cognitive;Communication;Conscious;Consumption;Data;Dedications;design;Development;digital;early adolescence;Eating;Eating Disorders;Elements;Environment;experience;Exposure to;girls;Habits;indexing;Influentials;innovation;intergenerational;Intervention;Investments;Link;Longitudinal Studies;Measures;media use;Mental Depression;Mental Health;Methods;novel;Outcome;parental role;Parents;Patient Self-Report;Perception;Persons;Play;Prevention;prospective;Psychopathology;Public Health;Reporting;Research;Risk;Risk Factors;Sampling;Self Assessment;Self Perception;seventh grade;Shapes;sixth grade;smartphone application;social;Social Development;social media;Source;stem;Stimulus;Symptoms;Technology;Testing;Time;transmission process;video chat;Visual;Visual Accommodation;Visual attention;visual processing;visual tracking;Work;Youth

PROJECT_TITLE: Social Media Use in Early Adolescence: Implications for Body Image


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Atherosclerosis;Biotechnology;Cardiovascular;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Liver Disease

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The gene tribbles pseudokinase 1 (TRIB1) has been repeatedly identified by human genome-wide associations studies as a key regulator of cardiometabolic health in human, and in vivo mouse studies have highlighted the importance of hepatic Trib1 in these associations. However, despite the overwhelming human and experimental evidence of the importance of TRIB1, very little is known about its effects on human physiology and health. The proposed studies in this diversity supplement application have leveraged a unique human genetics data set to identify rare DNA variants in CEBPA, the direct target of TRIB1 function, and the functional consequences of these variants will be tested in vitro and in vivo in hopes of identifying humans with loss of function in the TRIB1- C/EBPɑ regulatory axis.

PI_NAMEs: BAUER, ROBERT CLAYTON (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: 8q24;Address;adeno-associated viral vector;adiponectin;Animal Model;Binding Sites;Biological Assay;C57BL/6 Mouse;Cardiometabolic Disease;cardiometabolism;CEBPA gene;Cells;Cholesterol;chronic liver disease;Cloning;Complementary DNA;Complex;computerized tools;Coronary Arteriosclerosis;Custom;Data;Data Set;Disease;DNA;Dyslipidemias;Enzymes;exome sequencing;experimental study;factor C;Fatty Liver;Genes;Genetic;genetic association;genetic manipulation;Genetic Transcription;Genetically Modified Animals;genome resource;genome wide association study;genomic locus;Glycosylated hemoglobin A;Goals;Health;Hepatic;Hepatocyte;hepatoma cell;High Density Lipoprotein Cholesterol;Human;human disease;Human Genetics;Human Genome;In Vitro;in vitro testing;in vivo;Injections;Investigation;Knock-out;Knowledge;LDL Cholesterol Lipoproteins;Link;Lipids;Liver;liver metabolism;Location;loss of function;loss of function mutation;Luciferases;Measurement;Mediating;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolic syndrome;Molecular;Molecular Conformation;mortality;Mus;mutant;Mutation;non-alcoholic fatty liver disease;novel;overexpression;Pakistan;parent project;Parents;Pathway interactions;Phenotype;Physiology;Plasma;Plasmids;Population;Pre-Clinical Model;preclinical study;Process;protein function;Proteins;Proteomics;Recombinants;Regulation;Reporter;Research;Role;Site-Directed Mutagenesis;Specificity;structural biology;Techniques;Testing;Therapeutic;therapeutic evaluation;trait;transcription factor;transcriptome sequencing;translational potential;Triglycerides;Ubiquitination;Untranslated RNA;Validation;Variant;Western World;Wild Type Mouse;Work

PROJECT_TITLE: Molecular Mechanisms of TRIB1 Regulation of Hepatic Metabolism

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: FAYETTEVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: PROJECT NARRATIVE The overall goal of this administrative supplement is to explore the potential of a novel artificially designed hybrid growth factor to regulate the metabolism of fat and cancer cells. The collaborative efforts of the COBRE investigators at AIMRC and MHIR are expected to yield valuable clues in the rational design of therapeutics against metabolic dysfunction leading to the onset of cancers.

PI_NAMEs: QUINN, KYLE PATRICK (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: adipocyte differentiation;Adipocytes;Adipose tissue;Administrative Supplement;Advanced Development;Arkansas;Binding;Bioenergetics;Biogenesis;Biology;Biomedical Research;biophysical properties;C-terminal;cancer cell;cancer risk;carbohydrate metabolism;Cell Line;Cell model;Cell Proliferation;Cells;Centers of Research Excellence;Chimera organism;Chimeric Proteins;Collaborations;comparative;Complex;Confocal Microscopy;Consumption;CRISPR/Cas technology;cytokine;Data;Data Science;design;Development;Diabetes Mellitus;Diamond-Blackfan anemia;Diffuse;Disease;Distant;early onset;Endocrine;Exhibits;Extracellular Matrix;Fatty acid glycerol esters;FGF1 gene;FGF21 gene;Fibroblast Growth Factor;fibroblast growth factor 21;Fibroblast Growth Factor Receptors;Fluorescence;Foundations;FRAP1 gene;Future;Genus Hippocampus;Glucose;Glycerol;Goals;Growth;Growth Factor;Health;Hela Cells;Heparin;High-Risk Cancer;Hormones;Human;Hybrids;Image;Immunofluorescence Microscopy;in vivo;Individual;insulin sensitivity;Interdisciplinary Study;knock-down;Knock-out;Label;Lipase;lipid biosynthesis;lipid metabolism;Lipids;Lipolysis;Maine;Malignant Neoplasms;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic Pathway;Metabolism;Mitochondria;Modeling;Monitor;Morphology;mTOR Signaling Pathway;multidisciplinary;Mutation;N-terminal;NADH;Names;Nonesterified Fatty Acids;novel;novel therapeutic intervention;Obesity;Oils;Organ;overexpression;oxidation;Oxidation-Reduction;Oxidative Stress;Patients;Phase;Phenotype;Phosphorylation;Pilot Projects;polysome profiling;Positioning Attribute;PPAR alpha;Predisposition;Production;Proliferating;Property;Protein Biosynthesis;Protein Isoforms;protein metabolism;Proteins;Proteome;Proteomics;rational design;receptor binding;Recombinants;Regulation;Research;Research Institute;Research Personnel;Respiration;restoration;Ribosomal Proteins;ribosome profiling;Ribosomes;ribosomopathy;risk mitigation;Role;Signal Transduction;Signaling Protein;Small Interfering RNA;Spectrum Analysis;Stains;structural biology;Tail;Testing;Therapeutic;Therapeutic Intervention;Tissues;Transcript;transcription factor;Translating;two photon microscopy;two-photon;Universities;Variant

PROJECT_TITLE: Arkansas Integrative Metabolic Research Center


ADMINISTERING_IC: DP

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: IOWA CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Working with other funded Cancer Prevention and Control Research Network collaborating centers, UI CPCRN will conduct research to reduce the burden of cancer in rural areas through evidence-based prevention and control interventions. The proposed research studies focus on the public health problem of cancer, particularly the prevention of cancers caused by the human papillomavirus (HPV).

PI_NAMEs: AFIFI, RIMA ;ASKELSON, NATOSHIA M. (contact)

PROGRAM_OFFICER_NAME: DARLING, NATALIE

PROJECT_TITLE: UI Cancer Prevention and Control Research Network Collaborating Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 FMC (04)]


ORG_DEPT: NUTRITION

PHR: PROJECT NARRATIVE We will study why some parents opt out of school vaccine requirements. We will work with school communities on new ways to support parents to get required vaccines. Our goal is to protect individuals and communities from measles and other diseases that vaccines can prevent.

PI_NAMEs: AMMERMAN, ALICE S (contact);GILKEY, MELISSA B

PROJECT_TITLE: Engaging school communities to prevent exemptions to kindergarten vaccination mandates

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 OHI (09)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Rural Health

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: West Virginia has the lowest life expectancy in the nation and ranks at or near the bottom in many chronic disease categories. The overarching goal of the West Virginia Clinical and Translational Science Institute is to grow research that accelerates delivery of solutions to health disparities in West Virginia.

PI_NAMEs: HODDER, SALLY LYNN (contact)

PROGRAM_OFFICER_NAME: BISSONETTE, GREG

PROJECT_TERMS: 2019-nCoV;Academic Medical Centers;Acceleration;addiction;Address;Alzheimer's Disease;Appalachian Region;Award;Cardiovascular Diseases;Categories;Chronic Disease;Chronic lung disease;Clinical;Clinical Research;Clinical Sciences;cohort;Cohort Studies;Collaborations;Color;Communication;Communities;community engagement;Community Outreach;County;COVID-19;COVID-19 pandemic;COVID-19 patient;Death Rate;Development;Environmental Hazards;equity, diversity, and inclusion;Exposure to;Funding;Goals;Grant;Health;health care service organization;health disparity;Health Resources;HIV;Human;Human Resources;improved;Incidence;Institution;Lead;Leadership;Life Expectancy;Malignant Neoplasms;Medical center;medical schools;National Institute for Occupational Safety and Health;new epidemic;next generation;Osteopathic Medicine;Outcome;Policies;Positioning Attribute;Post-Acute Sequelae of SARS-CoV-2 Infection;practice-based research network;predictive modeling;Primary Care;Productivity;programs;Public Health;Publications;Registries;reproductive;Research;Research Infrastructure;Research Personnel;Rural Community;Rural Health;Rural Population;Science;Scientist;Site;substance use;Substance Use Disorder;success;Testing;Training;Translational Research;translational scientist;Trust;United States;United States Department of Veterans Affairs;United States National Institutes of Health;West Virginia;Work

PROJECT_TITLE: West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cannabinoid Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Depression;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Mental Illness;Neurosciences;Pain Research;Prevention;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE We propose to investigate reward and pain circuitry in cannabis use and depression comorbidity in young people (ages 18-34) living with HIV (PLWH) in the Bronx, New York in light of the high rates of substance use, reduced adherence to HIV treatment, and suboptimal viral suppression in this population. This collaborative proposal bridges disciplines of depression, neuroimaging, HIV, and addiction in an effort to improve our understanding of neural mechanisms underlying co-occurring cannabis use and depression in young PLWH and has the potential to improve HIV, substance use, and mental health outcomes. This research is expected to facilitate the identification of specific biomarkers to serve as key diagnostic features and may result in new treatment strategies suggested by improved understanding of mechanisms of disease.

PI_NAMEs: GABBAY, VILMA  (contact);SHARMA, ANJALI ;STARRELS, JOANNA L.

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: addiction;Adherence;Age;age group;Amygdaloid structure;Analgesics;Anhedonia;Anterior;Anxiety;Appointment;behavioral construct;Binding;Blood Tests;Brain;Cannabis;causal model;CD4 Lymphocyte Count;Chronic;Clinic;CNR1 gene;cognitive function;cognitive testing;cohort;comorbid depression;comorbidity;Complex;computerized;Corpus striatum structure;Data;Depressed mood;depressive symptoms;design;Development;Diagnosis;Diagnostic;Discipline;Disease;disorder control;Epidemic;Evaluation;Expectancy;follow-up;Functional Magnetic Resonance Imaging;Future;Gender;Goals;graph theory;Habenula;Health;health disparity;Health system;HIV;HIV/AIDS;Hypersensitivity;Image;imaging modality;improved;indexing;Insula of Reil;Learning;Light;Machine Learning;machine learning classification;Maps;marijuana use;marijuana use disorder;marijuana user;Measures;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;midbrain central gray substance;Modeling;mood symptom;Morbidity - disease rate;neural;neural circuit;neuroimaging;neuromechanism;Neurons;New York;nicotine use;novel;novel therapeutic intervention;Nucleus Accumbens;Outcome;Pain;pain processing;pain scale;pain sensitivity;pain symptom;Participant;Pattern;Persons;Play;Population;Poverty;Process;Research;research clinical testing;Resolution;response;Rest;reward anticipation;reward circuitry;reward dysfunction;reward processing;Rewards;Risk Behaviors;Role;Self Assessment;Serum;Severities;Severity of illness;Sex Orientation;Signal Transduction;Sleep;specific biomarkers;Structure;substance use;Substance Use Disorder;subthreshold depression;suicidal;System;Testing;Tetrahydrocannabinol;Thalamic structure;Trauma;Ventral Tegmental Area;Viral;Viral Load result;Work;young adult

PROJECT_TITLE: The Neural Underpinnings of Depression and Cannabis Use in Young PLWH


ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The University of Arizona and the University of Texas, Houston research teams will collaborate in this innovative study that looks to perform intervention implementation costing and cost-effectiveness analyses (CEA) (cost- benefit, -utility, and -effectiveness) of the evidence-based Managing Epilepsy Well network self-management program, MINDSET, in community and clinical settings, using retrospective and prospective data. This project is significant in providing data for decision-makers regarding the economic feasibility of implementing an ESM evidence-based program (MINDSET) in clinic and community settings.

PI_NAMEs: CARVAJAL, SCOTT CARTER;LABINER, DAVID M (contact);SEPULVEDA, REFUGIO UNITED STATES

PROJECT_TITLE: SIP24-008 Economic analysis of an evidence-based MEW epilepsy self-management intervention (MINDSET) in community and healthcare settings.

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 OHI (08)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Microbiome;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PI_NAMEs: CAO, YIN  (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Address;adenoma;Adenomatous Polyps;Age;Alcohols;Animal Model;anti-cancer research;Biochemical;Biological;Biological Factors;Biological Models;biological specimen archives;Birth;Blood;cancer initiation;Cells;Characteristics;Chemicals;cohort;Collaborations;Colon;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;Computational Biology;Data;data harmonization;Development;Diet;Dimensions;Discipline;DNA Methylation;early onset;early onset colorectal adenoma;early onset colorectal cancer;Ecosystem;Electronic Health Record;Environment;Environmental Risk Factor;Epidemiologic Factors;Epidemiology;Epigenetic Process;epigenome;Ethnic Origin;Etiology;Exposure to;Feces;Future;Generations;Genetic Transcription;Genomics;Geography;Goals;gut microbiome;high risk;Homeostasis;human data;Immunology;imprint;Incidence;Individual;individualized prevention;innovation;Intervention;Investigation;Lesion;Life Cycle Stages;life span;Life Style;lifestyle intervention;Link;Location;Malignant Neoplasms;Mediating;Metagenomics;microbial signature;microbiome;Mind;Modeling;Modification;Molecular;novel;obesogenic;pharmacologic;Phase;Physiological;Population;Positioning Attribute;Predisposition;Prevention;Prevention strategy;Process;Prospective Studies;Questionnaires;Race;Research;Research Activity;Resolution;response;Risk;Risk Assessment;Risk Factors;Role;small molecule;social;social determinants;stem cell biology;Technology;Tissues;Translating;transmission process;tumor initiation;tumor progression;tumorigenesis;Universities;Vision;Washington;Work

PROJECT_TITLE: PROSPECT-Global Consortium and Risk Factor Discovery


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The Texas Developmental Center for AIDS Research (Texas D-CFAR) will facilitate collaborative and multidisciplinary HIV research. The Texas D-CFAR will align with NIH HIV research priorities to foster synergy, promote efficiency, and support coordinated research between its home institutions - Baylor College of Medicine (Houston), University of Texas Health Science Center at Houston, and the Texas Biomedical Research Institute (San Antonio). The Texas D-CFAR will build research capacity to achieve its goal: End HIV and Optimizing Health in Texas.

PI_NAMEs: GIORDANO, THOMAS P (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Area;Award;Basic Science;Biomedical Research;Biometry;Biostatistics Core;Black Populations;California;Caring;Censuses;Clinical;Clinical Trials;Collaborations;college;combat;Communication;community advisory board;Community Outreach;County;Coupled;Development;Disparity;Environment;Epidemic;epidemic preparedness;Event;federal policy;Fostering;Funding;Funding Opportunities;Goals;Health;health determinants;Health Disparities Research;Health Insurance;Health Sciences;Health Services;HIV;HIV diagnosis;Home;Human Resources;improved;innovation;Institution;interest;Knowledge;Latinx population;Leadership;Learning;Medicaid;Medicine;member;Mentors;Mission;multidisciplinary;next generation;nonhuman primate;Occupational activity of managing finances;Outcome;Persons;Pilot Projects;Policies;Population;Population Heterogeneity;Prevention;Procedures;Process;Program Development;programs;Public Health;recruit;Request for Applications;Research;Research Infrastructure;Research Institute;Research Personnel;Research Priority;Research Project Grants;Research Support;Resource-limited setting;Resources;Risk;Scientist;Services;Strategic Planning;substance use;symposium;synergism;Texas;Training;Training Support;transmission process;Treatment outcome;United States National Institutes of Health;Universities;US State;Viral;virology;working group

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SA-A (S1)]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PI_NAMEs: NEWELL, ALANA D (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Age;Area;Attention;Award;Basic Science;biomedical informatics;Biomedical Research;Biostatistics Core;Budgets;career;Career Choice;career development;Clinical;co-infection;Collaborations;college;Communicable Diseases;Communities;comorbidity;Development;Discipline of Nursing;early-career faculty;Educational workshop;Eligibility Determination;Environment;equity, diversity, and inclusion;Evaluation;Exposure to;Faculty;faculty support;Fostering;Funding;Funding Opportunities;Future;Grant;Growth;Health;health disparity;Health Sciences;high school;High School Student;HIV;Home;Infrastructure;Institution;interest;Interest Group;Intervention;Investments;Knowledge;Letters;Link;Medical;Medicine;member;Mentors;Mission;Modeling;Outcome;Outcome Measure;outreach;outreach program;peer;peer coaching;Peer Review;Persons;Pilot Projects;Process;programs;Public Health;Publications;Research;Research Institute;Research Personnel;Research Priority;Research Project Grants;Research Support;Resources;response;Rest;Review Committee;Science;Series;Services;skills;Students;substance use;symposium;System;Texas;United States National Institutes of Health;Universities;Work;working group;Writing

PROJECT_TITLE: Texas Developmental Center for AIDS Research


ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative Our work and that of others implicate a type of white blood cell, macrophages, in the activation and maintenance of fibrosis, a pathological condition that accounts for up to 45% of all deaths annually in the United States. The studies we propose will target macrophages using a novel cellular therapeutic approach that has been used with success in the treatment of cancer, in which we will engineer T cells to attack macrophages directly and secrete anti-fibrotic molecules. We will use multiomic and spatial transcriptomic approaches to investigate the pathological relationship between macrophages, fibroblasts, and other cells that contribute to fibrosis, and will determine how these interactions are altered by our novel therapeutic intervention.

PI_NAMEs: WHITFIELD, MICHAEL L (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Address;Affect;Antigen Targeting;Antigens;Autoimmune Diseases;Award;Binding;Bioinformatics;Biological;Biology;biomarker validation;cancer therapy;CAR T cell therapy;Case Fatality Rates;Cell Therapy;Cells;Cellular immunotherapy;Centers of Research Excellence;Cessation of life;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;chronic autoimmune disease;Cicatrix;Clinical Trials;Coculture Techniques;Collagen;combat;curative treatments;cytokine;Cytolysis;Cytoplasm;Data;Deposition;design;design and construction;Development;Disease;Dose;engineered T cells;Engineering;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Fibronectins;Fibrosis;Functional disorder;Future;Goals;Grant;Heterogeneity;Immune;Immune System Diseases;Immunotherapy;in vivo;Inflammation;Inflammatory;insight;Killer Cells;Leukocytes;Link;Lymphocyte;Macrophage;Maintenance;Malignant Neoplasms;Mediating;Mediator;Mission;Modification;Molecular;monocyte;mouse model;multiple omics;Normal tissue morphology;novel;novel therapeutic intervention;Organ;Organism;parent project;Parents;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Peptides;preclinical study;Process;profibrotic cytokine;Pulmonary Fibrosis;reparative process;Resolution;Resources;response;Signal Transduction;single cell analysis;skin fibrosis;Small Business Innovation Research Grant;Specificity;success;Surface;systemic autoimmune disease;Systemic Lupus Erythematosus;Systemic Scleroderma;T-Cell Activation;Technology;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic target;therapeutically effective;therapy development;tissue injury;tissue repair;Tissues;transcriptomics;Translations;Treatment Efficacy;United States;United States National Institutes of Health;Work;wound healing

PROJECT_TITLE: Center for Quantitative Biology: a focus on “omics”, from organisms to single cells Supplement 4


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The Emory CFAR will contribute to ending the HIV epidemic by accelerating the highest caliber translational research — fostering team science, equity, and multidirectional stakeholder engagement. We will strive to build community trust in research through the intentional inclusion of key stakeholders at all stages of the research pipeline. We will achieve our goals by providing innovative services, tools, expertise, and access to state-of- the-art equipment through an Administrative Core, including the Adelante Research Capacity Program, a Developmental Core, five Science Cores (Biostatistics and Bioinformatics; Clinical Research; Prevention and Implementation Sciences; Systems Immunology; and Virology and Molecular Biomarkers); and two Scientific Working Groups (SWGs) - Health Equity and Next Generation Therapeutics.

PI_NAMEs: CHAHROUDI, ANN M;DEL RIO, CARLOS  (contact);KELLEY, COLLEEN F

PROJECT_TERMS: Acceleration;access disparities;Acquired Immunodeficiency Syndrome;Address;African American;Area;Basic Science;bench to bedside;Bioinformatics;Biometry;Caliber;career;career development;Clinical Research;Collaborations;Communities;community academic partnership;community building;community engagement;community organizations;County;Coupled;cultural competence;Data;Development;early-career faculty;Epidemic;Equipment;Equity;Faculty;Fostering;Funding;Funding Mechanisms;Geographic Locations;Geography;Goals;health care availability;health disparity;health equity;health equity promotion;Hispanic;HIV;Home;Immunology;implementation science;improved;Infrastructure;innovation;Latina;Latino;Latinx;Latinx population;life span;Location;member;Mentors;Mission;molecular marker;Morehouse School of Medicine;Newly Diagnosed;next generation;novel therapeutics;Personal Satisfaction;Persons;Phase;Population;pre-clinical research;Prevention;programs;Public Health;recruit;Research;research and development;Research Personnel;Research Priority;Risk;Role;Science;Services;skills;success;System;Teacher Professional Development;tool;Training;Translating;Translational Research;Trust;United States National Institutes of Health;Universities;virology;working group

PROJECT_TITLE: Center for AIDS Research at Emory University


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases

PI_NAMEs: DEL RIO, CARLOS  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Area;Award;Basic Science;Biomedical Research;career;career development;Clinical Sciences;cohort;Collaborations;Communication;Communities;community academic partnership;community engagement;design;Development;dissemination strategy;diversity and inclusion;Ensure;Epidemic;Equity;Funding;Funding Mechanisms;Goals;Grant;Growth;health disparity;health equity promotion;Hispanic;HIV;innovation;Investments;Latina;Latino;Latinx;Leadership;leadership development;member;Mentors;Mentorship;Mission;multidisciplinary;next generation;Participant;peer;Population;Prevention;programs;recruit;Research;research and development;Research Personnel;Research Priority;Resource Allocation;Resources;Science;Services;skills;success;Teacher Professional Development;tool;Training Programs;Underrepresented Minority;United States National Institutes of Health;Universities;Woman;working group

PROJECT_TITLE: Core A: Administrative


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Biotechnology;Cancer;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: RICHMOND

ORG_DEPT: DENTISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative The oncogenic transcription factor MYCN drives a subset of deadly neuroblastoma and remains undruggable; therefore, finding synthetic lethal relationships that may result in new treatments is one of the “holy grails” of pediatric cancer therapy. In the parent grant proposal, we provide evidence that amplified MYCN orchestrates a complex and intricate re-wiring of the neuroblastoma cell to 1) increase iron metabolism, 2) increase cysteine and selenocysteine biosynthesis to counteract reactive oxygen species created from iron metabolism-related Fenton reactions and 3) increase synthesis of pantothenate kinase 3 (PANK3) to subsequently increase coA levels; the result of which is the creation of a synthetic lethality and therapeutic vulnerability to ferroptosis induction which we aim to explore, clarify and translate to new therapeutic options for this recalcitrant pediatric tumor. In this diversity supplement, we will expand our investigations based on newly published data that telomerase inhibitors are potent ferroptosis inducers, and further rooted in the understanding that telomerase is a key MYCN-driven dysfunctional pathway in neuroblastoma, we will determine the efficacy of clinically- advanced telomerase inhibitors in combination with canonical Ferroptosis inducers.

PI_NAMEs: FABER, ANTHONY CHARLES (contact);OLZMANN, JAMES A

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Anabolism;Antioxidants;Apoptosis;Apoptotic;Applications Grants;BCL1 Oncogene;cancer cell;cancer therapy;Cell Culture Techniques;Cell Death;Cell Line;Clinic;Clinical;clinical efficacy;Clinical Investigator;Coenzyme A;Combined Modality Therapy;Complex;Cysteine;Data;Dependence;Drug Metabolic Detoxication;Drug Targeting;efficacy evaluation;experimental study;FDA approved;Genetic;Genomics;Glutathione;glutathione peroxidase;Goals;Grant;improved;inhibitor;Investigation;Iron;iron metabolism;kinase inhibitor;Malignant Childhood Neoplasm;Malignant Neoplasms;mouse model;MYCN gene;Neuroblastoma;neuroblastoma cell;novel;novel therapeutics;Oncogenes;Oncogenic;Pantothenate kinase;parent grant;Pathway interactions;patient derived xenograft model;Patients;Pediatric Neoplasm;Pharmacologic Substance;Phenotype;pre-clinical;Production;programs;Publishing;Reaction;Reactive Oxygen Species;Refractory;Research Design;resistance mechanism;screening;Selenocysteine;Telomerase;Telomerase inhibition;Telomerase Inhibitor;Therapeutic;Time;transcription factor;Translating;treatment response;tumor;Work

PROJECT_TITLE: MYCN drives a ferroptotic vulnerability in neuroblastoma


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: Project Narrative We confirm that the scope of the parent grant (R01AI168163) will remain unchanged, and the proposed research will provide insights into the molecular mechanisms of drug resistance in Plasmodium vivax. The study will assess parasite invasion, survival, and development during reticulocyte maturation, assessing whether parasites in younger reticulocytes have reduced susceptibility to drugs. We will identify the corresponding host receptors essential for the invasion of P. vivax into reticulocytes of different ages, and these studies will inform P. vivax drug treatment policy and resistance mitigation.

PI_NAMEs: DURAISINGH, MANOJ T (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Affect;African ancestry;Age;Anti-malarial drug resistance;Anti-malarials;Antigen Receptors;Antigens;Binding;Binding Proteins;Blood Group Antigens;Cell surface;Cells;chemokine receptor;CRISPR/Cas technology;Development;Disease;Drug resistance;Erythrocytes;Genetic Variation;Growth;Immune system;insight;Invaded;Knock-out;Knowledge;Ligands;Malaria;Membrane;Metabolic;Molecular;novel;Organelles;parasite invasion;Parasites;parent grant;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;Plasmodium vivax;Policies;Population;Predisposition;programs;Proliferating;Proteins;Public Health;receptor;Reporting;Research;Resistance;resistance mechanism;Reticulocytes;Surface;Work

PROJECT_TITLE: Molecular basis of antimalarial drug resistance in Plasmodium vivax


PHR: Project Narrative In response to SIP-24-009, this proposal establishes an Arthritis Management and Wellbeing Research Network (AMWRN) Collaborating (Component A) and the Coordinating (Component B) Center embedded within the infrastructure of the Osteoarthritis Action Alliance (OAAA), a national public health coalition focused on the OA Public Health Agenda. The Collaborating Center will address a stated research priority to pilot test, evaluate, and translate OACareTools+, an innovative and efficient intervention developed by the OAAA, that represents an HCP-informed and inexpensive solution for integrating HCP screening, counseling, and referral to increase engagement of diverse patients with arthritis in Arthritis-Appropriate, Evidence-Based Interventions. Together, the efforts from these Components will support the work of the AMWRN to identify and promote awareness of arthritis-related research priorities and findings, conduct and disseminate research, and translate science into actionable, scalable public health practices to benefit diverse adults with arthritis.

PI_NAMEs: AMMERMAN, ALICE S (contact);CALLAHAN, LEIGH FLEMING

PROJECT_TITLE: Establishing a Collaborating Center for OACareTools PLUS (OACareTools Primary care-Led Usability & Scalability Study) and a Coordinating Center for an Arthritis Management & Wellbeing Research Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 FMC (10)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Microbiome;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: CAMBRIDGE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD UNIVERSITY

PI_NAMEs: BALSKUS, EMILY PATRICIA (contact);BUENROSTRO, JASON DANIEL

PROJECT_TERMS: Address;adenoma;Adenomatous Polyps;Age;Alcohols;Animal Model;anti-cancer research;Biochemical;Biological;Biological Factors;Biological Models;cancer initiation;Cells;Chemicals;cohort;Collaborations;Colon;Colorectal Cancer;colorectal cancer risk;Colorectal Neoplasms;Computational Biology;Data;Development;Diet;Dimensions;Discipline;Disease;early onset;early onset colorectal cancer;Ecosystem;Environment;Environmental Risk Factor;Epidemiologic Factors;Epidemiology;Epigenetic Process;epigenome;Etiology;Experimental Models;falls;follow-up;Genetic Transcription;Genomics;Goals;gut microbiome;high risk;Homeostasis;Immunology;imprint;Incidence;Individual;innovation;Lesion;Life Cycle Stages;life span;lifestyle intervention;Link;Malignant Neoplasms;Mediator;microbial;microbiome;Mind;Modeling;Modification;Molecular;mouse model;multiple omics;novel;obesogenic;Pathway interactions;pharmacologic;Physiological;Population;Positioning Attribute;Predisposition;prevent;Prevention;Process;Research;Resolution;response;Risk Assessment;Risk Factors;Sampling;screening;small molecule;social determinants;stem cell biology;Technology;Tissues;transcriptomics;Translating;tumor progression;tumorigenesis;Vision;Work

PROJECT_TITLE: PROSPECT: Pathways, Risk factors, and mOleculeS to Prevent Early-onset Colorectal Tumors


ORG_CITY: BALTIMORE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

ORG_STATE: MD

PHR: Adoptive T cell therapy has offered remarkable treatment successes for several cancers but the clinical implementation of this promising therapy has been hampered by the development of life-threatening immunotoxicities, such as cytokine-release-syndrome (CRS). We recently identified that catecholamines produced by macrophages contribute to the development of CRS. The proposed research aims to determine how catecholamines modulate macrophage function and cytokine release induced by CART cells in mice and human. !

PI_NAMEs: BAI, RENYUAN ;STAEDTKE, VERENA  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Adrenergic Agents;Adrenergic Receptor;alpha-Methyltyrosine;anakinra;antagonist;Antitumor Response;B lymphoid malignancy;Biological Assay;Cancer Patient;cancer therapy;Catecholamines;CD14 gene;CD19 gene;Cell Therapy;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical implementation;Coculture Techniques;CRISPR/Cas technology;cytokine;cytokine release syndrome;Data;data sharing;Dedications;Development;effective intervention;Epinephrine;Functional disorder;Genetic;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Hematologic Neoplasms;Human;IL6 gene;Immune;immune activation;immune function;Immune response;immune-related adverse events;Immunosuppression;Immunotherapy;immunotoxicity;improved;In Vitro;in vivo;in vivo evaluation;indexing;Individual;Inflammatory;inhibitor;Institution;Interleukin-6;knock-down;Knock-out;Knockout Mice;Laboratories;leukemia;Life;Macrophage;Macrophage Activation;Malignant Neoplasms;Measures;Mediating;Mediator;Modeling;Molecular;mortality;mouse model;Mus;Myelogenous;Myeloid Cells;neoplastic cell;NOS2A gene;novel;Pathogenesis;Patient Monitoring;Patient-Focused Outcomes;Patients;Pennsylvania;Peripheral Blood Mononuclear Cell;pharmacologic;Prazosin;prevent;Production;Productivity;receptor;Receptor Signaling;Research;response;Role;Safety;Sampling;Scientist;Serum;Severities;Shapes;small hairpin RNA;Solid Neoplasm;success;Supportive care;Symptoms;T cell response;T cell therapy;T-Lymphocyte;Therapeutic;therapy outcome;TNFSF5 gene;tool;Toxic effect;translational potential;tumor;tumor eradication;Tyrosine 3-Monooxygenase;United States National Institutes of Health

PROJECT_TITLE: Adrenergic modulation of cellular immune functions in CAR T cell-induced cytokine release syndrome


ADMINISTERING_IC: DC

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ATHENS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Project Narrative Taste bud cell differentiation from progenitors is essential for the homeostasis of taste buds and intact taste sensation that is important for life and quality of life as it guides nutritional choices and motivates food intake. Prior studies on the regulation in taste cell differentiation have focused on the molecular signals in epithelium. Proposed studies on the effects of cell products of connective tissue on taste cell differentiation will generate data to fill the significant knowledge gaps of whether the underlying connective tissue plays essential roles in regulating the cell renewal of mature taste buds in adult animals, which will bring forward better understanding of molecular regulation in taste cell differentiation in the context of all surrounding tissue compartments.

PI_NAMEs: LIU, HONGXIANG  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: 3-Dimensional;Adult;Apical;appendage;Basal Cell;Cell Differentiation process;Cells;Cellular Structures;Circumvallate Papilla;Conditioned Culture Media;Connective Tissue;Connective Tissue Cells;Data;Eating;Embryo;Embryonic Development;Epithelial Cells;epithelial stem cell;Epithelium;Esthesia;Fungiform Papilla;Gene Modified;Homeostasis;Hydrogels;in vivo;in vivo evaluation;Individual;Injections;Knowledge;Lamina Propria;Life;life span;Mammals;mature animal;Mesenchymal;Mesenchyme;Modeling;Molecular;Molecular Weight;Mus;Neural Crest;neurotransmission;novel;Nuclear;Nutritional;Oral;Organoids;Pattern;Play;pleiotrophin;Population;Production;progenitor;Protein Secretion;Proteins;Quality of life;Regulation;Reporter;Research;Rodent;Role;SHH gene;Side;Signal Transduction;Signaling Molecule;Signaling Protein;Solid;Sorting;Specialized Epithelial Cell;stem cell differentiation;Stereotyping;Structure;System;Tamoxifen;Taste Bud Cell;Taste Buds;Taste Disorders;Taste Perception;Testing;therapeutically effective;Time;Tissues;Tongue;tongue apex;tongue papilla;Transgenic Mice

PROJECT_TITLE: Regulation of connective tissue in the cell renewal of mature taste buds

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: BLOOMINGTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE The development of effective disease-modifying interventions for Alzheimer’s disease and related dementias (ADRD) that preserve cognitive function, prolong independence, and delay custodial care would improve quality of life for millions of people and save the U.S. billions of dollars per year. The proposed research examines social, cognitive, and biological mechanisms underlying relationships between personal social networks and neurodegeneration and cognitive decline. By increasing our understanding of biosocial processes in the neurology of aging, this project is intended to help identify novel targets for intervention that prevent or slow the trajectory of cognitive decline in ADRD, reducing the burden of ADRD and age-related cognitive impairment on individuals, caregivers and families, and the healthcare system.

PI_NAMEs: PERRY, BREA LOUISE (contact)

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: Acceleration;acute stress;Adult;adverse childhood events;Age;Age-associated memory impairment;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Attenuated;Biological;Biological Process;Biosocial;Black race;Brain;Brain Mapping;Brain Pathology;Brain region;brain volume;Buffers;Caregivers;cerebral atrophy;Characteristics;Chronic stress;Clinical;Cognitive;Cognitive aging;cognitive function;cognitive reserve;cognitive testing;cohort;Communities;Consensus;Custodial Care;Data;Data Collection;data integration;Data Reporting;Data Set;Development;Diagnosis;Disease;Education;Eligibility Determination;Environment;ethnic discrimination;Ethnic Origin;Etiology;Event;Exposure to;Family;follow-up;Funding;Genotype;Goals;Healthcare Systems;high dimensionality;high risk;high school;Home;Impaired cognition;improved;Indiana;Individual;insight;Intervention;Interview;Knowledge;Life;Life Cycle Stages;Link;Longitudinal Studies;Mediating;Medical;Methods;mild cognitive impairment;Modeling;Nerve Degeneration;neuroimaging;Neurologic;Neurology;neuropathology;novel;older adult;Outcome;Participant;Pathology;Pathway interactions;Patient Self-Report;peer;perceived stress;Persons;Phase;Population;preservation;prevent;Process;protective effect;Quality of life;Race;recruit;Research;resilience;Resources;Role;Sample Size;Sampling;Science;social;social attachment;Social Network;Social Processes;Social support;socioeconomic diversity;socioeconomics;Stress;Testing;Variant

PROJECT_TITLE: Social Networks in Alzheimer Disease 2.0.

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Prevention;Social Determinants of Health

ORG_NAME: BROAD INSTITUTE, INC.

PI_NAMEs: HUTTENHOWER, CURTIS  (contact)

PROJECT_TERMS: Address;adenoma;Adenomatous Polyps;Age;Alcohols;Animal Model;anti-cancer research;Biochemical;Biological;Biological Factors;Biological Models;cancer initiation;Cells;Chemicals;cohort;Collaborations;Colon;Colorectal Cancer;colorectal cancer risk;Colorectal Neoplasms;Computational Biology;Data;Development;Diet;Dimensions;Discipline;early onset;early onset colorectal cancer;Ecosystem;Environment;Environmental Risk Factor;Epidemiologic Factors;Epidemiology;Epigenetic Process;Etiology;Genetic Transcription;Genomics;Goals;high risk;Homeostasis;Immunology;Incidence;Individual;innovation;Lesion;Life Cycle Stages;life span;lifestyle intervention;Link;Malignant Neoplasms;microbiome;Mind;Modeling;Modification;Molecular;novel;obesogenic;Pathway interactions;pharmacologic;Population;Positioning Attribute;Predisposition;prevent;Prevention;Process;Research;Resolution;Risk Assessment;Risk Factors;small molecule;social determinants;stem cell biology;Technology;Tissues;Translating;tumor progression;tumorigenesis;Vision;Work


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Hypertension;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative Blood pressure is a key risk factor for many cardiovascular diseases, and hypertension was primarily responsible for about 7.8 million world-wide deaths in 2015 alone. The rapidly accumulating genomic data are crucial for understanding the disease mechanism of hypertension, including its racial differences. The proposed study will not only help advance precision medicine by identifying the causative genomic variants of hypertension for each individual, but also help predict, intervene and prevent hypertension via developing advanced machine learning predictive models for hypertension.

PI_NAMEs: LIU, JINLING  (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Address;African American population;American;Appointment;Automobile Driving;Biological Sciences;biomedical informatics;Blood Pressure;blood pressure regulation;Cardiovascular Diseases;cardiovascular risk factor;career development;catalyst;causal model;causal variant;Cessation of life;Clinical Data;cloud based;cohort;Complex;Data;data integration;Data Set;deep learning;Development;Development Plans;Disease;Ecosystem;Engineering;Environmental Risk Factor;Ethnic Origin;European;Extramural Activities;feature selection;Fellowship;Frequencies;genetic architecture;genetic variant;Genome;genome sequencing;Genome Stability;genome wide association study;genomic data;Genomics;Genotype;Goals;high dimensionality;Hypertension;Individual;Institution;Intervention;Joints;Learning;life span;machine learning model;machine learning prediction;Malignant Neoplasms;member;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Missouri;Modeling;Multiomic Data;multiple omics;National Heart, Lung, and Blood Institute;novel;Parents;Patients;Performance;personalized genomics;Phenotype;Play;Population;population based;Population Sizes;Postdoctoral Fellow;precision medicine;predictive modeling;Prevalence;prevent;Prevention;professor;programs;racial difference;racial disparity;Research;Research Personnel;Research Support;Risk;Risk Factors;Role;Science;Signal Pathway;Single Nucleotide Polymorphism;skills;social determinants;success;System;Technology;theories;Time;Training;Trans-Omics for Precision Medicine;tumor;United States National Library of Medicine;Universities;Variant;variant detection;whole genome

PROJECT_TITLE: A novel framework for estimating personalized genomic variants of hypertension for precision medicine

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: OMAHA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Narrative Recently-developed human bone marrow organoid (hBMO) systems can mimic the biology of normal and diseased hematopoietic niches. Our goal is to build robust genetic and computational tools using hBMOs for disease modeling and drug screening. A team science approach is needed to generate reproducible hBMOs in vitro, test physiological and stress hematopoietic models, establish engraftment protocols for human leukemia, and build machine learning tools to map developmental trajectories and disease-induced changes in organoids.

PI_NAMEs: SORGEN, PAUL L (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Acute Myelocytic Leukemia;acute stress;Address;Administrative Supplement;Amino Acid Motifs;Architecture;Area;Artificial Intelligence;Assistantship;Award;Bioinformatics;Biological Assay;Biological Models;Biology;Biomedical Research;Black race;Blood Cells;Blood Platelets;bone;Bone Marrow;cancer cell;Candidate Disease Gene;Cell Separation;Cell surface;Cell Survival;cell type;Cells;Cellularity;Chronic stress;Collaborations;Communicable Diseases;Communities;Complex;computer framework;computerized tools;Core Facility;Data;data integration;Data Set;Defect;Development;differentiation in vitro;Disease;disease model;Disease Progression;Disparate;Doctor of Philosophy;Drug Screening;Dysplasia;education resources;Embryoid bodies;Engraftment;Environment;Erythropoiesis;Exhibits;Extramural Activities;Faculty;faculty research;faculty support;Failure;falls;Feedback;Functional disorder;functional genomics;Funding;Gene Expression;Gene Expression Profile;Genetic;Genetic Transcription;Genomics;Goals;Growth;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Hematopoietic System;Heterogeneity;high-throughput drug screening;higher education;Human;Image;In Vitro;induced pluripotent stem cell;Infrastructure;insight;Institution;inter-individual variation;interest;knockout gene;Knowledge;leukemia;Leukemic Cell;leukemogenesis;Link;Machine Learning;machine learning model;Malignant - descriptor;Malignant Neoplasms;Maps;Marrow;matriculation;Medical center;Metastatic Neoplasm to the Bone;Methods;Modeling;Molecular;mouse model;Mus;Nebraska;Neoplasm Metastasis;Network-based;novel;Organoids;parent project;Parents;Patients;Pattern;Pharmacotherapy;Physiological;Play;Privatization;Production;Productivity;programs;Proliferating;Protocols documentation;Publishing;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;response;Role;SAM Domain;Scholars Program;Science;Signal Transduction;single-cell RNA sequencing;Solid Neoplasm;species difference;stem cell differentiation;stem cell fate;stem cell function;Stress;Structure;student training;Students;System;Techniques;Technology;Testing;Time;tool;Training Programs;transcription factor;Transcription Repressor;transcriptome sequencing;transcriptomics;undergraduate research;undergraduate student;Universities;Vascularization;Work

PROJECT_TITLE: Nebraska Research Network in Functional Genomics


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: DURHAM

ORG_NAME: UNIVERSITY OF NEW HAMPSHIRE

PHR: The University of New Hampshire’s first COBRE: Center of Integrated Biomedical and Bioengineering Research (CIBBR) has substantially improved the biomedical and bioengineering research environment during Phase 1, as evidenced by the number of research project grant awards and publications by CIBBR investigators, the career advancement of CIBBR faculty, and major investments in biomedical research infrastructure. Building upon these accomplishments, the overall goal of CIBBR in Phase 2 is to expand the Center’s research portfolio through continued hiring of new biomedical and bioengineering faculty, creation of a new Data Science Core, acquisition of new instruments in conjunction with a business plan, and enhancements to the mentoring program and administrative operations. These actions will have a powerful and sustained impact on biomedical and bioengineering research at UNH by increasing our knowledge of basic biomedical science and bioengineering, expediting the development of clinically relevant diagnostic tools and treatments, and advancing biomedical workforce training capacity in the state of New Hampshire.

PI_NAMEs: COTE, RICK H (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Acceleration;Administrative Supplement;Advisory Committees;Advocate;Area;Award;Biomedical Engineering;Biomedical Research;Businesses;career;career development;Career Mobility;Centers of Research Excellence;clinical development;clinically relevant;Collaborations;Communication;Computational Biology;Core Facility;Data Science Core;Dedications;Development;diagnostic tool;early-career faculty;Ecosystem;Educational workshop;Effectiveness;effectiveness research;Environment;Evaluation;Faculty;faculty mentor;Faculty Recruitment;Funding;Goals;Grant;Health;Human;improved;Infrastructure;innovation;Institution;instrument;instrumentation;Interdisciplinary Study;Investments;Knowledge;Leadership;Measurement;Mentors;model design;Molecular;multidisciplinary;multiple omics;New Hampshire;operation;Operations Research;Outcome;Performance;Phase;Phenotype;Pilot Projects;Program Development;Program Evaluation;programs;Publications;recruit;Research;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Science;Services;Technology;Training;Translations;United States National Institutes of Health;Universities

PROJECT_TITLE: Team Science Administrative Supplement to Center of Integrated Biomedical and Bioengineering Research (CIBBR)


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Hepatitis;Liver Disease

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: PROJECT NARRATIVE Type 1 (T1D) and Type 2 (T2D) diabetes are associated with serious health complications, one of which is non- alcoholic fatty liver disease (NAFLD) where hepatic stellate cells, endothelial, and immune cells interact and cause a self-perpetuating pro-inflammatory and pro-fibrogenic network that can eventually progress into liver cirrhosis. However, the true extent of the cell-specific contributions, and how these cells orchestrate the propagation of liver damage are not known, as previous studies mainly focused on the role of individual cell types rather than their interactions. Therefore, given the PI’s combined expertise on different cell types and experimental approaches, our research will focus on examining the cell type-specific changes underlying T1D- and T2D-induced NAFLD in an in vivo setting, which is expected to uncover novel mechanisms that may lead to more effective therapies for NAFLD.

PI_NAMEs: XIA, LIJUN  (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Affect;Affinity Chromatography;American;Area;Award;Benign;Beta Cell;Biochemical;Biological Assay;Cell Communication;cell type;Cells;Centers of Research Excellence;Chronic;chronic liver disease;Collaborations;comorbidity;Complication;Data;Development;Diabetes Mellitus;diabetic;Disease;Disease Progression;DNA Sequence Alteration;effective therapy;Endothelial Cells;Endothelium;Evaluation;Fibrosis;Fluorescence-Activated Cell Sorting;Gene Expression Profile;Genetic Transcription;Goals;Health;Health Care Costs;Healthcare Systems;Hepatic;Hepatic Stellate Cell;Histologic;Immune;immune cell infiltrate;in vivo;Inbred NOD Mice;Individual;Inflammation;Inflammatory;insight;interest;Knowledge;Liver;Liver Cirrhosis;Liver diseases;Liver Fibrosis;liver injury;Mediating;Medical Care Costs;men;Metabolic dysfunction;Metabolic stress;Metabolism;Modeling;Molecular;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Oklahoma;Outcome;parent project;Parents;pathogen;Pathogenesis;Pathology;Patients;Pharmacological Treatment;Phenotype;Research;Research Project Grants;Research Support;Resources;response;Ribosomes;Risk;Role;single cell sequencing;single-cell RNA sequencing;Technology;Testing;therapeutic target;transcriptomics;Translating;type I and type II diabetes;western diet

PROJECT_TITLE: Center for Cellular Metabolism Research in Oklahoma


ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

PHR: Project Narrative The University of Iowa Advancing Research on Immunization Services Network Center (UI-ARISe) will serve as an ARISe collaborating and coordinating center. We propose a new theoretical framework, “Vaccination as Motivation Social Cognition”, for understanding how people think, feel, and behave regarding vaccines and will develop and evaluate a new intervention target based on this framework, which we call “motivational fit”, to improve vaccine outcomes. Specifically, we will identify psychological drivers of specific dimensions of vaccine hesitancy for US adults living in metropolitan and non-metropolitan areas and develop vaccination promotion strategies that refocus the psychological driver for each vaccine hesitancy dimension to align with vaccine confidence and immunization service utilization.

PI_NAMEs: AFIFI, RIMA ;ASKELSON, NATOSHIA M. (contact);SCHERER, AARON MICHAEL

PROJECT_TITLE: UI Advancing Research in Immunization Services Network Coordinating Center


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK GENOME CENTER

PI_NAMEs: ROBINE, NICOLAS  (contact)

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: Address;Africa;African;African ancestry;anti-cancer research;Area;Benchmarking;biobank;Bioinformatics;Biological;Biological Factors;Biopsy Specimen;black patient;Cancer Center;cancer health disparity;Characteristics;Chromosome Mapping;clinically relevant;cloud based;cohort;Collaborations;Complex;computer framework;Data;Data Element;data repository;Databases;Dedications;Detection;early onset;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;epigenome;Equity;experimental study;Feedback;Genes;Genetic;Genetic study;Genetic Variation;Genome;genome sequencing;Genomics;Geography;Germ Lines;Goals;Human Genome;human pangenome;human reference genome;Immune;Immunoassay;Immunologic Factors;Immunologics;improved;Incidence;Inequality;Inequity;innovation;Intervention;Link;Lived experience;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;marginalized population;Mass Spectrum Analysis;Measurement;Measures;member;Methodology;Methods;Molecular;Molecular Biology;nanopore;New York;novel;outcome disparities;pan-genome;Participant;Patient advocacy;Patient Self-Report;Patients;Phenotype;Plasma;Policies;Population;precision oncology;Predisposition;Primary Neoplasm;profiles in patients;racism;rare variant;recruit;reference genome;Research;Research Personnel;Resources;response;Sampling;Science;Scientist;sequencing platform;Shotguns;single molecule;Site;social;social determinants;Surveys;sustainability framework;Technology;Testing;tool;transcriptome sequencing;transcriptomics;treatment and outcome;trial design;tumor;Tumor Tissue;Underserved Population;United Kingdom;United States;Variant;Vertebral column;virtual;whole genome;Work;working group

PROJECT_TITLE: SAMBAI - Social, Ancestry, Molecular Biology analyses of Inequities


NIH_SPENDING_CATS: Genetics

ORG_CITY: PITTSBURGH

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Activation of nuclear receptors, a family of ligand-dependent transcription factors, is used extensively in pharmacology to develop drug targets for diverse medical conditions, including metabolic disease and cancer. I will use experimental and computational approaches to investigate the role of pioneer factor Foxa2 in modulating chromatin accessibility to enable binding of nuclear receptor LXRα upon ligand activation.

PI_NAMEs: BOCHKIS, IRINA  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Adverse effects;Affect;aged;Agonist;antagonist;Atherosclerosis;Bile Acids;Binding;Binding Sites;Cell Nucleus;Central Nervous System;Cholesterol Homeostasis;Chromatin;Clinical;Clinical Trials;Complex;Congestive Heart Failure;Data;Dependence;Development;Diabetes Mellitus;Disease;Distal;DNA;DNA Binding;Drug Targeting;Dyslipidemias;Family;Fatty Acids;Fracture;Future;Gene Expression;Gene Expression Regulation;Genes;genetic corepressor;Genomic approach;Genomics;glucose metabolism;in vivo;Ligand Binding;Ligand Binding Domain;Ligands;lipid metabolism;Liquid substance;Liver;Liver diseases;LXRalpha protein;Malignant Neoplasms;Medical;Metabolic Diseases;Metabolism;Molecular Conformation;mutant;Nuclear Receptors;Nucleosomes;Patients;Peroxisome Proliferator-Activated Receptors;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physiological;Play;Positioning Attribute;PPAR alpha;PPAR gamma;Predisposition;Process;receptor;receptor binding;reduce symptoms;Role;segregation;Severities;side effect;Site;Testing;Thiazolidinediones;Thinking;transcription factor;Transcription Initiation;Up-Regulation;Weight Gain

PROJECT_TITLE: Role of Foxa2 in ligand-dependent activation of nuclear receptors

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

PHR: NARRATVIE OVERALL Developmental Biology research is fundamental to progress in determining the molecular basis of many diseases, as well as for the rapidly emerging field of regenerative medicine. Our goals in this Phase III COBRE are to consolidate the progress we have made in Phases I and II by welcoming new Developmental Biologists into our community through the support of Pilot Projects and to expand the services offered by our Imaging and Bioinformatics and Pathways Cores, while at the same time positioning them for sustainability when COBRE funding ends.

PI_NAMEs: THOMPSON, LINDA F (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Address;Advisory Committees;Age;Appointment;Area;Bioinformatics;Biomedical Research;Caenorhabditis elegans;Cardiovascular system;career;Cell Culture Techniques;Cell model;Centers of Research Excellence;Communities;competitive environment;Core Facility;Development;Developmental Biology;Disease;Doctor of Philosophy;Dropout;Drosophila genus;Environment;Epigenetic Process;Faculty;Fertilization;functional genomics;Funding;Future;Genome;Genomic approach;Goals;Hematopoietic stem cells;Hereditary Disease;Human;human disease;human model;Image;Immune system;Infrastructure;Institution;Interdisciplinary Study;International;Journals;Laboratories;member;men;Mentors;model organism;Molecular;Mus;Mutation;novel therapeutic intervention;Oklahoma;operation;Pathway interactions;Phase;Physiological Processes;Pilot Projects;Planarians;Positioning Attribute;Productivity;programs;Publishing;Regenerative Medicine;Research;Research Personnel;Research Support;Resources;Scientist;Senior Scientist;Services;System;Systems Development;Time;Training;trend;United States National Institutes of Health;Universities;Woman;Work;Zebrafish

PROJECT_TITLE: Expanding Excellence in Developmental Biology in Oklahoma


ORG_NAME: GEORGIA STATE UNIVERSITY

PHR: NARRATIVE Hispanic/Latinx (“H/L”) communities experience unique barriers to smoking cessation, contributing to cancer- related inequities. This project will culturally and linguistically adapt an evidence-based digital health smoking cessation intervention for H/L, leveraging community engagement and implementation science to optimize the benefits and reach of the intervention through healthcare and community settings. The Georgia State University Cancer Prevention and Control Research Network (CPCRN) Collaborating Center will engage in large-scale network efforts to increase the impact of this project and others on cancer health equity.

PI_NAMEs: ERIKSEN, MICHAEL PAUL;SPEARS, CLAIRE ADAMS (contact)

PROGRAM_OFFICER_NAME: DARLING, NATALIE

PROJECT_TITLE: Implementing a culturally appropriate digital health intervention to reduce tobacco-related cancer disparities among Hispanic/Latinx Communities


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rare Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative/Public Health Significance Colorectal cancer (CRC) is the second leading cause of cancer-related deaths and the third most commonly diagnosed cancer worldwide. Regular use of colonoscopy contributes to a decrease in CRC incidence rates, but one-third of eligible Americans have not undergone CRC screening and missed screening accounts for 28-44% of CRC-related deaths. The primary goal of the proposed research is to optimize colorectal cancer surveillance for early-onset CRC by personalizing it according to each individual's estimated CRC risk for both incidence and mortality.

PI_NAMEs: HUR, CHIN  (contact);KASTRINOS, FAY

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Adherence;advanced disease;Age;aged;American;Attitude;Black Populations;cancer diagnosis;Cancer Etiology;cancer health disparity;Cessation of life;Colonoscopy;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;colorectal cancer screening;comorbidity;Cost Savings;Deimplementation;Diagnosis;Disparity;DNA;early onset colorectal cancer;early screening;Effectiveness;Eligibility Determination;Feces;Focus Groups;Fostering;Funding;Gender;Genes;Genotype;Goals;Grant;Health;Health Personnel;Hereditary Nonpolyposis Colorectal Neoplasms;Hybrids;improved;improved outcome;Incidence;Individual;innovation;lifetime risk;Malignant Neoplasms;Modality;Modeling;models and simulation;Morbidity - disease rate;mortality;MSH6 gene;mutation carrier;novel;Outcome;Patient risk;Patients;Personal Satisfaction;Persons;Play;PMS2 gene;population health;Procedures;Provider;Public Health;Regimen;Research;Resource Allocation;Resources;Risk;Risk Estimate;Risk Factors;risk stratification;Role;screening;Source;surveillance strategy;Surveys;Testing;United States

PROJECT_TITLE: Optimal Colorectal Cancer Surveillance Strategy for Lynch Syndrome by Genotype

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Kidney Disease;Organ Transplantation;Orphan Drug;Prevention;Rare Diseases;Transplantation

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Summary Kidney fibrosis, or scarring of the kidney, is a strong predictor of loss of kidney function as well as kidney transplant rejection. However the only way to detect kidney fibrosis is with invasive biopsy which only samples a tiny fraction of the kidney. In this application we will develop a noninvasive imaging method to detect scarred kidneys.

PI_NAMEs: CARAVAN, PETER D (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Abbreviations;Acceleration;Adenine;Adult;Affect;Aging;Allografting;Amino Acids;analytical method;Animal Model;antibody-mediated rejection;Binding;Biochemical;Biodistribution;Biological Markers;Biopsy;Biopsy Specimen;Blood specimen;Cardiovascular Diseases;cardiovascular risk factor;Chronic;Chronic Kidney Failure;Chronic rejection of renal transplant;Cicatrix;Clinical;clinical translation;Clinical Trials;Collagen;Creatinine;crosslink;diagnostic tool;Dialysis procedure;Diet;Disease;Drug Kinetics;Early Diagnosis;End stage renal failure;Enzyme Inhibition;Enzymes;Etiology;fibrogenesis;Fibrosis;Functional disorder;Goals;good laboratory practice;Graft Rejection;Graft Survival;Hereditary nephritis;High Pressure Liquid Chromatography;high risk;Histologic;Human;Image;imaging modality;imaging probe;Inflammation;Injections;interstitial;Ions;Kidney;kidney biopsy;kidney fibrosis;kidney imaging;Kidney Transplantation;Label;Libraries;Macaca;Magnetic Resonance;Magnetic Resonance Imaging;manufacture;manufacturing process;Measures;Metals;Modeling;Monitor;Monkeys;mouse model;Mus;Natural History;Nephritis;nephrotoxicity;Non-Invasive Detection;non-invasive imaging;nonhuman primate;novel therapeutics;Output;Pathology;Pathway interactions;Patients;Peptidyl-Dipeptidase A;Plasma;Positron-Emission Tomography;predict clinical outcome;Predictive Value;prevent;Process;Prognostic Marker;programs;Protein-Lysine 6-Oxidase;Protocols documentation;Public Health;Radiolabeled;Radiometry;Rattus;Recovery;Renal function;renal ischemia;Renal Replacement Therapy;Renal Tissue;Reperfusion Injury;Reporting;Research;Residencies;response;Risk;Rodent;Rodent Model;Safety;Sampling;Sampling Errors;Scanning;Serum;success;Surrogate Endpoint;Technology;Time;Tissue Donors;Tissues;tool;Toxic effect;Toxicology;Translations;Transplant Recipients;Transplantation;treatment response;uptake

PROJECT_TITLE: PET Imaging of Renal Fibrosis

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PI_NAMEs: ELEMENTO, OLIVIER  (contact)

PROJECT_TERMS: admixture mapping;Africa;African;African ancestry;Alternative Splicing;anti-cancer research;Automobile Driving;biobank;Biological;black patient;Blood;cancer health disparity;cancer type;Carcinogens;CCND1 gene;CDK4 gene;cell type;Cells;cloud based;cohort;Collaborations;computer framework;Data;Data Element;data repository;Databases;Defect;Diet;DNA Methylation;DNA Repair;early onset;Environment;Environmental Carcinogens;Environmental Exposure;Epigenetic Process;Equity;ERBB2 gene;Event;Evolution;Exposure to;Gene Frequency;Genes;Genetic;genetic analysis;genetic signature;genetic variant;Genetic Variation;genome sequencing;Genomic Instability;Genomics;Genotype;Geography;Germ Lines;Germ-Line Mutation;Housing;Immunoassay;Immunologic Factors;Immunologics;improved;Incidence;Inequality;Inherited;insertion/deletion mutation;Link;Lived experience;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;marginalized population;Mass Spectrum Analysis;Measurement;Measures;member;Mendelian randomization;Menthol;Methods;Molecular;Molecular Biology;mRNA Expression;Mutagenesis;Mutation;novel;outcome disparities;Output;Patient advocacy;Patient Self-Report;Patients;Pattern;Phenotype;PIK3CA gene;Plasma;Population;precision oncology;Predisposition;Primary Neoplasm;profiles in patients;PTEN gene;Quantitative Trait Loci;racism;Regulatory Element;Research;Research Personnel;Resources;response;Sampling;Science;Scientist;Signal Transduction;social;social determinants;social health determinants;Somatic Mutation;Stromal Cells;Surveys;sustainability framework;Technology;TMPRSS2 gene;Tobacco;TP53 gene;trait;transcriptomics;treatment and outcome;trial design;tumor;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;Underserved Population;Variant;virtual;whole genome;Work

PROJECT_TITLE: SAMBAI: Societal, Ancestry and Molecular Biology Analyses of Inequalities


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE This proposed research aims to understand the role of cancer survivorship care plans (SCP) on mortality. The research will use novel machine learning technologies to determine the heterogeneity in risk factors associated with mortality in cancer survivors. With the number of cancer survivors exceeding 18 million, prioritizing the mitigation of late health complications, addressing the knowledge gap in the use of SCPs and understanding the role of SCPs is critical in reducing mortality and enhancing outcomes for cancer survivors nationwide.

PI_NAMEs: BLAES, ANNE H. (contact);LASKA, MELISSA N.;MARMOR, SCHELOMO

PROJECT_TITLE: Understanding the impact of survivorship care plans on health outcomes in cancer survivors

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 OHI (03)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_DEPT: NEUROLOGY

ORG_STATE: IA

PHR: Project Narrative Alzheimer’s disease causes incredibly morbidity and mortality and have few truly effective treatments. This proposal explores the fundamental mechanisms of glucose metabolism in Alzheimer’s with the hope of generating new biomarkers and treatments.

PI_NAMEs: ZHANG, QIANG  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Acceleration;aerobic glycolysis;Affect;Age Months;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapy;American;Amyloid;Animal Model;antagonist;Automobile Driving;Binding;Biochemistry;Biogenesis;Biological Markers;Biology;Brain;brain dysfunction;Caloric Restriction;Citric Acid Cycle;Clinical Trials;cognitive function;cognitive performance;Control Groups;cytokine;Data;Data Set;Diabetes Mellitus;Disease;Disease Progression;effective therapy;Enzyme-Linked Immunosorbent Assay;Exercise;Female;fluorodeoxyglucose positron emission tomography;Functional disorder;Future;Gas Chromatography;Gene Expression;glucose metabolism;Glycolysis;human data;Image;Immunohistochemistry;Immunotherapy;Impaired cognition;Impairment;improved;in vivo;in vivo imaging;Interdisciplinary Study;Intervention;Magnetic Resonance Spectroscopy;male;Mass Spectrum Analysis;Measures;Metabolic Diseases;Metabolism;metabolomics;Mitochondria;Morbidity - disease rate;mortality;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;neuron loss;Neuronal Dysfunction;novel;Obesity;Patients;Pharmaceutical Preparations;Phosphoglycerate Kinase;Physiology;Positioning Attribute;Positron-Emission Tomography;Process;Production;protein aggregation;proteostasis;Resolution;Risk Factors;risk mitigation;RNA Interference;Rodent;Rodent Model;side effect;tamsulosin;tau Proteins;Techniques;terazosine;Testing;transcriptome sequencing;transcriptomics;Western Blotting;Work

PROJECT_TITLE: Glycolysis and rodent models of Alzheimer's disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The Mountain West Arthritis Secondary Prevention Program will to investigate scalable strategies to improve the reach of evidence-based interventions for persons with osteoarthritis who in rural, low income and ethnically diverse communities. The research in this proposal will result in generalizable translational tools and scalable strategies that can benefit other communities, health systems and persons with arthritis.

PI_NAMEs: ESTABROOKS, PAUL ;FRITZ, JULIE M (contact)


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dietary Supplements;Digestive Diseases;Genetics;Human Genome;Microbiome;Nutrition;Precision Medicine;Prevention

ORG_CITY: SEATTLE

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

ORG_STATE: WA

PHR: PROJECT NARRATIVE The ecological structure of the human gut microbiome helps determine nutritional and phenotypic responses to diet. However, a clear mapping does not yet exist between diet, gut microbial ecology, gut microbial community metabolism, and human metabolic phenotypes. In this proposal, we design and test an integrated host- microbiome-diet metabolic model for rapidly and accurately predicting personalized responses to dietary inputs.

PI_NAMEs: GIBBONS, SEAN MICHAEL (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: absorption;Adult;Algorithms;Bile Acids;Biological;Biological Assay;Blood;blood lipid;Body Weight decreased;cell type;cohort;commensal microbes;Communities;Complex;Data;design;Diet;dietary;Dietary intake;Dietary Intervention;Digestion;Ecology;experimental study;fecal metabolome;fecal microbiome;Feces;gastrointestinal epithelium;Growth;gut microbiome;gut microbiota;Health;Heterogeneity;host microbiome;Human;Human Microbiome;improved;in silico;In Vitro;innovation;Intervention;Maps;Measurement;Metabolic;metabolic phenotype;Metabolism;metabolome;metabolomics;metagenome;Metagenomics;microbial;microbial community;microbiome;microbiome research;Modeling;Multiomic Data;novel;nutrition;Nutritional;Participant;personalized predictions;Persons;Pharmaceutical Preparations;Phenotype;Physiology;Polysaccharides;Precision Health;precision nutrition;reconstruction;Resources;response;Sampling;Structure;Testing;Tissues;Training;Validation;Variant;Vitamins;Work

PROJECT_TITLE: CyberGut: towards personalized human-microbiome metabolic modeling for precision health and nutrition


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: Project Narrative The Department of Veterans Affairs is the largest provider of medical care to people with HIV in the U.S. While effective in extending survival in Veterans with HIV, the success of antiretroviral therapy (ART) is offset by the rising burden of obesity. Our data shows obesity in Veterans with HIV is a heterogeneous condition, with 36% having myosteatostic or myosteatostic + sarcopenic type obesity. The interaction of HIV, ART, and obesity, yield changes in adipose tissue function impairing ability to store energy, and thus, lipid infiltrates organs and skeletal muscle. Accumulation of this “ectopic” fat may be driven by mitochondrial dysfunction which promotes insulin resistance, risk for cardiometabolic disease, and loss of muscle physical function. This study will test co- administration of L-carnitine to promote oxidation of fatty acids, n-3 fatty acids to reduce muscle fat infiltration, and resistance exercise to promote muscle protein synthesis.

PI_NAMEs: KOETHE, JOHN ;SILVER, HEIDI JAYE (contact)

PROJECT_TERMS: Acceleration;acylcarnitine;Adipose tissue;Affect;antiretroviral therapy;Attention;Award;Bioenergetics;Cardiometabolic Disease;cardiometabolic risk;Cardiopulmonary;Cardiovascular Diseases;Caring;Central obesity;Clinical;cohort;Collaborations;Cross-Over Trials;cytokine;Data;Defect;density;Deposition;design;Diabetes Mellitus;dietary;Dietary Intervention;disability;Endocrinology;evidence base;Evidence based intervention;exercise intervention;Exercise Test;Exercise Tolerance;exercise training;experience;Fatty acid glycerol esters;fatty acid oxidation;fatty acid supplementation;Fatty Acids;Foundations;frailty;functional decline;Funding;glucose tolerance;Glucose tolerance test;glucose uptake;Goals;Health behavior;HIV;Human;Image;imaging science;Immunology;Impairment;improved;Indirect Calorimetry;Infiltration;Inflammation;Inflammatory;Insulin;Insulin Resistance;insulin sensitivity;Interleukin-1 beta;Interleukin-12;Interleukin-6;Intervention;Levocarnitine;Lipids;long chain fatty acid;Magnetic Resonance Imaging;Medical;Metabolism;Mitochondria;mitochondrial dysfunction;Muscle;muscle form;Muscle Mitochondria;muscle physiology;Muscle Proteins;Muscular Atrophy;novel;nutrition;Obesity;Omega-3 Fatty Acids;Organ;oxidation;Oxidative Phosphorylation;personalized care;Persons;Physical Function;Placebos;Plasma;preservation;Protein Biosynthesis;Proteolysis;Protocols documentation;Provider;Radiology Specialty;Randomized;randomized trial;Regimen;Regulation;Research;Research Personnel;resistance exercise;Risk;Sampling;sarcopenia;sarcopenic obesity;Skeletal Muscle;skeletal preservation;success;Testing;Thinness;Tissues;trial design;United States;United States Department of Veterans Affairs;Unsaturated Fats;Veterans;VO2max;Work;X-Ray Computed Tomography

PROJECT_TITLE: A Randomized Trial to Optimize Skeletal Muscle while Reducing Adiposity in Veterans with HIV.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 INFA-K (01)]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative Family caregivers are responsible for managing behavioral symptoms of dementia. This project will describe how family caregivers use medications to manage behavioral symptoms, and the consequences of medication management.

PI_NAMEs: PICKERING, CAROLYN E ZIMINSKI (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Address;Adverse effects;adverse outcome;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Behavioral Symptoms;biological adaptation to stress;care recipients;caregiver education;caregiver stress;Caregivers;caregiving;Caring;Characteristics;Chemicals;Classification;Clinical;Clinical assessments;Congresses;contextual factors;Data;Dementia;Dementia caregivers;diaries;disorder prevention;Distress;Dose;Elder Abuse;Enrollment;evidence base;experience;Family Caregiver;family caregiving;Family Practice;Foundations;Frequencies;Future;Geriatric Assessment;Goals;Health Professional;High Prevalence;high risk;Incidence;innovation;Intervention;Knowledge;Licensing;Longitudinal Studies;Measurement;Medical;medication administration;Medication Management;Meta-Analysis;Morbidity - disease rate;mortality;optimism;Outcome;Patients;Pattern;Persons;Pharmaceutical Preparations;Public Health;Randomized;Recommendation;Records;Reporting;Research;Research Priority;response;restraint;Role;Safety;screening;Surveys;symposium;symptom management;Symptoms;therapy design;Typology;United States National Institutes of Health;United States Preventative Services Task Force;Work

PROJECT_TITLE: Medication Administration and Chemical Restraints in Family Caregiving for Alzheimer's Disease and Related Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(02)]


ORG_CITY: PROVIDENCE

ORG_NAME: OCEAN STATE RESEARCH INSTITUTE, INC.

ORG_STATE: RI

PHR: PROJECT NARRATIVE: As people get older, they lose the ability to grow new blood vessels to help with healing particularly as cholesterol builds up in the blood vessels throughout the body. Our blood cells have the ability to activate the growth of new blood vessels, but the pathways involved and the impact of aging on this ability are not fully understood. This grant seeks to understand the age-acquired changes in certain genes that might influence the signals required for new blood vessel growth. This study will lead to new medicines that can improve blood vessel growth where needed for more rapid healing in older patients.

PI_NAMEs: MORRISON, ALAN ROSS (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: 3' Untranslated Regions;Acute;adhesion receptor;Age;age effect;age related;age-related disease;aged;Aging;aging related;angiogenesis;Angioplasty;Atherosclerosis;Binding;Binding Sites;Biogenesis;Blood Cells;Blood flow;Blood Vessels;Bypass;chemokine receptor;Cholesterol;Chronic;Clinical;CpG Islands;cytokine;Data;demethylation;Diabetes Mellitus;Disease;DNA;DNA Methylation;Dose;femoral artery;Genes;Grant;Growth;Half-Life;healing;Homeostasis;Impairment;improved;Infiltration;Inflammatory;inhibitor;Injury;Integrins;Interleukin-1 beta;Ischemia;Lead;Lesion;Ligation;limb ischemia;Macrophage;Mechanics;Mediating;Medicine;Messenger RNA;Methylation;MicroRNAs;Modeling;Molecular;Morbidity - disease rate;mortality;mRNA Instability;mRNA Stability;Mus;Muscle;Myelogenous;new growth;novel;old mice;older patient;Operative Surgical Procedures;Outcome;Pathway interactions;Perception;Peripheral arterial disease;Persons;Phenotype;Play;posttranscriptional;promoter;Protein Isoforms;Proteins;Recovery;response to injury;revascularization;Role;Signal Pathway;Signal Transduction;Site;Source;synergism;Therapeutic;therapy development;Tissue Preservation;Tissues;Transcript;Transcription Coactivator;Transfection;translational potential;Translations;treatment strategy;Untranslated RNA;Vascular Diseases;Vascular Endothelial Growth Factors;VEGFA gene

PROJECT_TITLE: Combining Targeted Demethylation with Noncoding RNA-mediated mRNA Stabilization as a Strategy for Therapeutic Arteriogenesis in the Aged

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: The original Project Narrative document has not changed as a result of the proposed supplement activities.

PI_NAMEs: KAISER, PETER  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Signal Transduction;Ubiquitin

PROJECT_TITLE: Ubiquitin and Metabolite Signaling


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

ORG_NAME: UNIVERSITY OF GEORGIA

PI_NAMEs: RIDELL, ANDREW  (contact)

PROJECT_TERMS: Animal Model;Animals;Basic Science;Brugia malayi;Contracts;Development;Evaluation;Genus Wuchereria;Production;Reagent;Research

PROJECT_TITLE: Task C13: Production and Distribution of Filarial Research Reagents


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Neurodevelopmental disorders (NDDs) effect up to 3% of the population by age 18, but there are very few effective treatments to address the root causes or alleviate symptoms of these disorders. Scientific advancements have led to clinical identification of various mutations associated with NDDs, but in many instances our understanding of the connections between these mutations and disease is far from complete. This project will address fundamental gaps in our understanding of one such protein complex with mutations tied to NDDs, in line with the goal of NINDS to understand basic mechanisms of neurological disorders.

PI_NAMEs: WECHSLER, THERESA FAITH (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Address;Affect;Age;Biological Models;Biology;career;Cell Physiology;Cells;Clinical;Complex;Data;Development;Disease;disease model;effective therapy;Event;Family;Foundations;Gene Deletion;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genome Stability;Goals;Health;Healthcare Systems;Human;imaging approach;Imaging Techniques;Impairment;Individual;innovation;Knowledge;Lead;Link;live cell imaging;messenger ribonucleoprotein;Messenger RNA;Metabolism;Methodology;Methods;Modeling;Molecular;mutant;Mutation;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Nervous System Disorder;Neurodevelopmental Disorder;Neurons;novel;Nuclear;Nuclear Export;Outcome;Pathology;Pathway interactions;Patients;Phase;Point Mutation;Population;programs;protein complex;Protein Dynamics;protein function;recruit;reduce symptoms;Regulation;RNA metabolism;RNA-Binding Proteins;Role;Saccharomyces cerevisiae;Saccharomycetales;Scientific Advances and Accomplishments;Shapes;skills;spatiotemporal;System;Techniques;Time;tool;Training;Transcript;Transcription Elongation;transcriptome;transcriptome sequencing;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Modeling THO complex neurodevelopmental disorder mutations in gene expression regulation using budding yeast

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-A(20)L]


ORG_CITY: ROCKVILLE

ORG_NAME: THE EMMES COMPANY, LLC

PI_NAMEs: STABLIN, DON  (contact)

PROJECT_TERMS: Adult;Age;Biological Specimen Banks;Case Report Form;Clinical;clinical center;clinical research site;Collaborations;Communication;Contracts;Data;Data Coordinating Center;data exchange;data integration;data management;data repository;Data Set;Dysmyelopoietic Syndromes;Funding;Information Systems;Link;Logistics;Manuals;Monitor;multiple data sources;National Heart, Lung, and Blood Institute;Natural History;Newly Diagnosed;Observational Study;operation;Participant;Procedures;programs;Protocols documentation;Publications;Qualifying;quality assurance;Reporting;Research Personnel;Research Priority;research study;Resources;Sampling;Secure;success;Syndrome;Training;Writing

PROJECT_TITLE: IGF::OT::IGF THE NATIONAL MYELODYSPLASTIC SYNDROMES (MDS) NATURAL HISTORY STUDY, DATA COORDINATING CENTER (DCC), TASK ORDER 03, SEPTEMBER 1, 2016-FEBRUARY 28, 2018


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: SAN MATEO

ORG_NAME: REVAGENIX, INC.

PI_NAMEs: CIRZ, RYAN  (contact)

PROJECT_TERMS: Advanced Development;antimicrobial resistant infection;Bacterial Drug Resistance;bacterial resistance;biodefense;candidate selection;Chemistry;Clinical assessments;Combating Antibiotic Resistant Bacteria;efficacy evaluation;Emerging Communicable Diseases;lead optimization;manufacture;pathogen;pre-clinical;product development;Pseudomonas aeruginosa;research and development;Research Support;safety assessment;Therapeutic;therapeutic candidate;therapeutic development

PROJECT_TITLE: Development of Therapeutic Products for Biodefense, Anti-Microbial Resistant (AMR) Infections and Emerging Infectious Diseases


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: LOGAN

ORG_NAME: UTAH STATE UNIVERSITY

PI_NAMEs: JULANDER, JUSTIN  (contact)

PROJECT_TERMS: Advanced Development;Anti-viral Agents;Biological Assay;Cell Line;Contracts;Development;In Vitro;in vitro testing;Lead;Maintenance;NPM1 gene;pandemic disease;pandemic potential;pandemic virus;programs;screening;therapeutic development;Viral;Virus

PROJECT_TITLE: Task B23: Comprehensive In Vitro Antiviral Screening Against Viruses of Pandemic Potential Under the Antiviral Program for Pandemics (APP) to Support Hit-to-Lead Studies


NIH_SPENDING_CATS: Infectious Diseases

PROJECT_TERMS: Advanced Development;Anti-viral Agents;Biological Assay;Cell Line;Contracts;Development;in vitro testing;Maintenance;screening panel;therapeutic development;Viral;Virus;Virus Diseases

PROJECT_TITLE: Task B21: Comprehensive Viral Screening Panel


NIH_SPENDING_CATS: Pediatric;Prevention;Rare Diseases

ORG_CITY: OKEMOS

ORG_NAME: MICHIGAN PUBLIC HEALTH INSTITUTE

ORG_STATE: MI

PI_NAMEs: FAULKNER, MEGHAN  (contact)

PROJECT_TERMS: Address;adjudication;Age;Algorithms;Autopsy;Bereavement;biobank;Blood specimen;Case Report Form;Categories;Centers for Disease Control and Prevention (U.S.);Cessation of life;Child;Childhood;Classification;Collaborations;Collection;Communities;Consent;Contracts;Data;Data Coordinating Center;Data Element;data registry;design;DNA;Ensure;Epidemiology;Evaluation;Event;evidence base;Family;Family member;family support;Funding;Genomics;Geographic Locations;Goals;improved;Incidence;Informed Consent;Investigation;Knowledge;Link;loved ones;Medical;National Heart, Lung, and Blood Institute;National Institute of Neurological Disorders and Stroke;Neurologist;Pathologist;phenotypic data;Population;population based;prevent;Prevention;Process;programs;prospective;Public Health;Registries;Research;research and development;Resource Development;Resources;Risk Factors;Sampling;Services;Standardization;sudden cardiac death;Sudden Death;Sudden infant death syndrome;sudden unexpected death in epilepsy;Surveillance Program;Tissues;United States;United States National Institutes of Health

PROJECT_TITLE: SUDDEN DEATH IN THE YOUNG CASE REGISTRY (SDY) - DATA COORDINATING CENTER BIOSPECIMEN AND CONSENT ACTIVITIES (DCC)


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PI_NAMEs: NORTON, ELIZABETH  (contact)

PROJECT_TERMS: Advanced Development;Animal Model;Antibiotic Resistance;Bacterial Drug Resistance;bacterial resistance;biodefense;Clinical;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Contracts;Disease Outbreaks;efficacy evaluation;efficacy testing;Emerging Communicable Diseases;Formulation;immunogenicity;Individual;manufacture;response;Safety;stability testing;Toxicology;vaccine candidate;vaccine development;Vaccines

PROJECT_TITLE: Advanced Development of Vaccine Candidates for Biodefense and Emerging Antibiotic-Resistant Infectious Diseases


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The number of physician-scientists in the United States has been steadily declining, and there is a major need for more basic and translational researchers focused on digestive, pancreatic, and liver related research. The Training Program in Gastrointestinal Sciences at the University of Pennsylvania Perelman School of Medicine has had historic success and remains at the leading edge in nurturing young researchers and ensuring their maturation into independent investigators in digestive, pancreatic, and liver diseases.

PI_NAMEs: KATZ, JONATHAN P (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

PHR: PROJECT NARRATIVE This project will test an intervention that uses electronic health tools, such as a website and text messages, combined with Community Health Workers to provide counseling on the weight-related behaviors of diet and physical activity among residents living in public housing developments. We will compare this intervention with electronic health tools only and a control group to better understand whether the addition of Community Health Workers contributes to better outcomes for weight loss.

PI_NAMEs: QUINTILIANI, LISA M. (contact)

PROGRAM_OFFICER_NAME: DEAN, DAVID WORTH

PROJECT_TERMS: Adoption;Behavior;behavior change;Behavioral;Body Weight decreased;Boston;cancer risk;care delivery;Cellular Phone;Cessation of life;Characteristics;Chronic Disease;Cluster randomized trial;Communities;Community Health Aides;comorbidity;comparison intervention;Control Groups;cost;Cost Effectiveness Analysis;Counseling;Coupled;design;Development;Devices;Diet;Diet Monitoring;digital;digital health;digital technology;Disease;Disparity;Education;Educational Materials;effective therapy;efficacy evaluation;eHealth;Environment;ethnic minority;ethnic minority population;Ethnic Origin;evidence base;expectation;Face;Feedback;fruits and vegetables;Health;Health behavior change;health disparity;Health Priorities;Health Promotion;High Prevalence;Housing;implementation fidelity;improved;Incidence;Income;incremental cost-effectiveness;insight;Institute of Medicine (U.S.);Intervention;intervention effect;knowledge base;Link;Low income;Low Income Population;low socioeconomic status;Malignant Neoplasms;Measures;Mediating;Mental Depression;mHealth;Minority Groups;Modeling;Monitor;mortality;Motivation;motivational enhancement therapy;nutrition;Obesity;Obesity associated cancer;Outcome;Overweight;Ownership;Participant;Persons;Physical activity;Pilot Projects;Policies;Population;Positioning Attribute;programs;Public Housing;Quality-Adjusted Life Years;Race;racial minority;racial minority population;Reporting;Research;research study;Resources;Risk Behaviors;Role;secondary outcome;Self Efficacy;social;social cognitive theory;Social Environment;Social support;sociodemographics;sugar;sweetened beverage;Technology;telephone based;telephone coaching;Testing;Text Messaging;tool;Treatment Efficacy;web site;Weight;Weight maintenance regimen

PROJECT_TITLE: Digital Health Supported Weight Management Intervention Delivered by Community Health Workers Among Public Housing Residents

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]