NIH_SPENDING_CATS: Genetics;Hematology;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Reticular Dysgenesis is a severe combined immunodeficiency syndrome caused by loss of the mitochondrial enzyme Adenylate Kinase 2 (AK2). AK2 links energy and nucleotide metabolism, and lack of AK2 causes reductive stress and defects in purine synthesis in myeloid cells, the cell type most affected in RD. Understanding the mechanisms by which AK2 deficiency undermines the proliferation of myeloid cells will allow us to identify better treatments for mitochondrial and metabolic diseases and more precise strategies for improving immunosuppression and cancer therapy by selectively manipulating purine metabolism.

PI_NAMEs: WEINACHT, KATJA GABRIELE (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Adenine Nucleotides;adenylate kinase;Adult;Affect;Alleles;Aspartate;ATP Synthesis Pathway;B-Lymphocytes;Blood;cancer therapy;Carbon;Carnitine;Catabolism;Cell Cycle;cell type;Cells;Citric Acid Cycle;Clustered Regularly Interspaced Short Palindromic Repeats;Cytoplasm;Deamination;Defect;Development;Electrons;Energy Metabolism;Enzymes;Erythroid;Excretory function;Exhibits;Failure;FRAP1 gene;Generations;Genetic Transcription;Hematological Disease;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Homeostasis;Human;Image;Impairment;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Inosine Monophosphate;insight;Isotopes;Knock-out;Life;Link;Lipids;loss of function mutation;Loss of Heterozygosity;Lymphopenia;Mass Spectrum Analysis;Mediating;Megakaryocytes;Metabolic;Metabolic Diseases;metabolomics;Mitochondria;Mitochondrial Diseases;mitochondrial metabolism;Modeling;Mus;Myeloid Cells;Myeloid Progenitor Cells;Myelopoiesis;NADH;NADH oxidase;Natural regeneration;novel;novel strategies;Nucleoside Hydrolases;nucleotide metabolism;Nucleotides;overexpression;Oxidation-Reduction;Pathology;Pathway interactions;Patients;Phenotype;Phosphorylation;progenitor;Proliferating;purine metabolism;Purines;Pyruvate;Recycling;reticular dysgenesis;Ribosomal RNA;Ribosomes;Severe Combined Immunodeficiency;Severe congenital neutropenia;Signal Transduction;stem;Stress;System;T-Lymphocyte;Testing;Therapeutic immunosuppression;Translations;Transplantation;Xenograft procedure

PROJECT_TITLE: Adenylate Kinase 2 Deficiency and the Failure of Myelopoiesis

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF EDUCATION

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: OMAHA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF NEBRASKA OMAHA

ORG_STATE: NE

PHR: PROJECT NARRATIVE Blockages of arteries in the legs are often treated with metal mesh tubes called stents to keep the arteries propped open. These stents often fail resulting in return of symptoms, repeat surgery, or amputation. We propose to develop and test an optimally-designed stent that bends and twists with the artery during walking, and we hypothesize that it will help arteries stay open longer by improving arterial healing.

PI_NAMEs: KAMENSKIY, ALEXEY  (contact);MACTAGGART, JASON

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Accounting;Age;Age Factors;Amputation;Angioplasty;Animals;Arteries;Behavior;Bilateral;Biomechanics;Blood flow;Cadaver;Cardiovascular system;Carotid Arteries;Characteristics;claudication;Clinical;comparative effectiveness study;Computer Models;cost effective;Coupled;critical limb Ischemia;Custom;Data;design;Devices;Diet;Disease;Ensure;Environment;Evaluation;Excision;experience;Failure;Family suidae;Fatty acid glycerol esters;follow-up;Fracture;Funding;Future;Geometry;healing;Heart;hemodynamics;Histologic;Human;Human Characteristics;Hyperplasia;iliac artery;Image;Implant;improved;in silico;In Vitro;in vivo;Incidence;Knee;Knowledge;Leg;Lesion;Limb structure;Location;Lower Extremity;manufacture;Manuscripts;Measures;mechanical properties;Mechanics;Metals;Methods;microCT;Modeling;Muscle Contraction;Patients;Pattern;Performance;Perfusion;Periodicals;Peripheral;Peripheral arterial disease;personalized medicine;porcine model;pre-clinical;Procedures;reconstruction;Repeat Surgery;restenosis;Risk Factors;Seminal;Severities;Side;Stents;Stress;Stretching;Structure of popliteal artery;success;sugar;Symptoms;Techniques;Testing;Tissues;Translating;Treatment Failure;Tube;Validation;Walking;Work

PROJECT_TITLE: Optimized Stents for the Femoropopliteal Artery

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE  This project will advance our understanding of how the cells that line blood vessels (endothelial cells) are formed, and how other cell types can be reprogrammed to convert into endothelial cells. This knowledge will lead to insights into vascular diseases and will enhance our ability to promote vessel development in organ re- pair and regeneration.

PI_NAMEs: MELERO-MARTIN, JUAN M;PU, WILLIAM TSWENCHING (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Biological Assay;Blood Vessels;candidate validation;Cell Communication;Cell Differentiation process;Cell Line;Cell Reprogramming;cell type;Cells;ChIP-seq;Chromatin;Co-Immunoprecipitations;Competence;Data;Development;Endothelial Cells;Endothelium;Epigenetic Process;Exhibits;Family;Foundations;Genes;Genetic Transcription;Goals;Homeostasis;Human;human induced pluripotent stem cells;Impairment;In Vitro;in vitro Assay;in vivo;induced pluripotent stem cell;insight;Knowledge;Molecular;Mus;Mutagenesis;Myeloid Cells;Natural regeneration;Nucleic Acid Regulatory Sequences;organ regeneration;organ repair;Pattern;Perfusion;Phenotype;Process;Property;protein protein interaction;Proteins;Proteomics;Regulation;Regulatory Element;repaired;single-cell RNA sequencing;Solid;Specific qualifier value;stem cell differentiation;stem cells;Supporting Cell;System;Technology;Time;transcription factor;Vascular Diseases;Vascular Graft;Vascular regeneration;Vascular System

PROJECT_TITLE: Regulation of endothelial cell specification

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: RELEVANCE: Psychosis is a debilitating psychiatric condition. Greater understanding of how abnormalities in brain development, such as disruptions in brain glutamate, during youth produce symptoms of psychosis or psychosis risk may be critical for the development of earlier and more effective treatments. This would benefit public health by reducing the great costs of psychosis to individuals and society at large.

PI_NAMEs: ROALF, DAVID R (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;Adolescent Behavior;Age;Anterior;Antipsychotic Agents;Area;Axon;Biological;Brain;Chemicals;Choline;Clinical;clinical high risk for psychosis;Cognitive deficits;cohort;Complement;Corpus Callosum;cost;Creatine;Data;Development;Diagnosis;Diagnostic;diagnostic value;Diffusion Magnetic Resonance Imaging;Disease Progression;Dopamine;early psychosis;effective therapy;emerging adult;Etiology;Exhibits;frontal lobe;Functional disorder;Funding;gamma-Aminobutyric Acid;Glutamate Receptor;Glutamates;Glutamine;Glutathione;Health;Human;Image;Impairment;in vivo;in vivo monitoring;Individual;innovation;Learning;Link;longitudinal design;Machine Learning;Magnetic Resonance;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measurable;Measures;Medial;Memory;Motor;multilevel analysis;N-Methylaspartate;neurochemistry;neurodevelopment;neuroinflammation;Neurons;neuropsychiatric disorder;neurotransmission;Neurotransmitters;nonhuman primate;novel;novel imaging technique;Parietal Lobe;Patients;Pattern;Pharmaceutical Preparations;Play;precision medicine;Prefrontal Cortex;Production;Protons;Psychiatry;Psychoses;psychosis risk;Puberty;Public Health;recruit;Research;Risk;Role;Sampling;Schizophrenia;Science;Sensory;Societies;Source;Structural defect;Structure;Symptoms;Synapses;System;Techniques;Time;trend;white matter;Work;Youth

PROJECT_TITLE: Ultra-high field GluCEST MRI and MRS in youth at risk for psychosis

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Immunotherapy;Orphan Drug;Rare Diseases;Skin Cancer;Stomach Cancer;Women's Health Research

PHR: This proposal is based on the hypothesis that cancer cells avoid triggering inflammatory death by pyroptosis, by  down- regulating  or  mutating  GSDME,  which  suppresses  effective  anti- tumor  immunity.  A  corollary  is  that  inducing  pyroptosis  in  cancer  cells  will  enhance  immune  control  and  responsiveness  to  chemotherapy  drugs.  Therapeutic strategies that induce GSDME and/or make cancer cells susceptible to pyroptosis may be effective  at activating anti- tumor immunity, controlling tumor growth and improving responses to conventional or targeted  drugs, radiation or immunotherapy.

PI_NAMEs: LIEBERMAN, JUDY  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Affect;Apoptosis;Apoptotic;Back;Brain;C-terminal;cancer cell;Cancer cell line;cancer vaccination;CASP3 gene;Caspase;CD8-Positive T-Lymphocytes;Cell Death;Cell Line;Cell membrane;Cell Survival;Cells;Cellular Stress;Cessation of life;chemotherapy;Chemotherapy and/or radiation;Cochlea;Colorectal;Colorectal Cancer;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;Data;deafness;Decitabine;Drug resistance;drug sensitivity;Drug Targeting;Effectiveness;Epidermal Growth Factor Receptor;Epigenetic Process;Etoposide;Family member;flexibility;Genes;Goals;Granzyme;Human;Immune;immune clearance;Immunity;Immunocompetent;immunodeficiency;immunogenic;Immunotherapy;improved;In Vitro;in vivo;Infection;Infiltration;Inflammation Mediators;Inflammatory;inhibitor;insight;Invertebrates;Kidney;Killer Cells;Knock-out;KRAS2 gene;Large Intestine;Lipid Binding;loss of function mutation;Lung;lung cancer cell;Lymphocyte;Malignant Breast Neoplasm;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Melanoma;Melanoma Cell;Metastatic Neoplasm to Lymph Nodes;Methylation;Mitochondria;Modeling;Mucous Membrane;Mus;Mutate;Mutation;N-terminal;Natural Killer Cells;neoplastic cell;Normal tissue morphology;overexpression;Peptide Hydrolases;perforin;Permeability;Phagocytosis;Pharmaceutical Preparations;Placenta;Predisposition;Protein Family;Radiation;recruit;Resistance;response;Role;Small Intestines;Stimulus;Stomach;Swelling;Syndrome;T-Cell Depletion;Testing;Therapeutic;Transplantation;treatment response;tumor;tumor growth;Tumor Immunity;Tumor Promotion;Tumor Suppressor Proteins;Tumor-infiltrating immune cells;tumorigenesis;VDAC1 gene;Western Blotting

PROJECT_TITLE: Gasdermin E and pyroptosis in cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Organ Transplantation;Transplantation

ORG_CITY: LOS ANGELES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The shortage and poor quality of donor organs represent major limitations facing liver transplantation, the gold standard of care in patients with end-stage liver disease and those with tumors of hepatic origin. The goal of this project is to improve long-term liver transplant outcomes as well as “rejuvenating” suboptimal hepatic tissue, and promoting homeostasis via hepatocyte – macrophage cross-regulation. Our findings should facilitate innovative interventions to improve the quality and size of the current organ supply, an absolute imperative for the full realization of success for solid organ transplantation.

PI_NAMEs: KUPIEC-WEGLINSKI, JERZY W (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Acute;Anti-Inflammatory Agents;Antigens;bench to bedside;biological adaptation to stress;Biological Markers;Biopsy Specimen;cell growth regulation;cell injury;Chronic;Clinical;clinically relevant;Coculture Techniques;cold stress;conditioning;cytokine;Cytoprotection;Deacetylase;Deacetylation;delayed graft function;Depressed mood;DNA-Binding Proteins;end stage liver disease;Enzymes;experience;experimental study;Feedback;functional improvement;Genetic Transcription;Goals;Hepatic;Hepatic Tissue;Hepatocyte;HIF1A gene;Homeostasis;Human;Hydrogen Peroxide;Hypersensitivity;Hypoxia;Hypoxia Inducible Factor;Immune;improved;in vitro Model;Inflammation;Inflammatory Response;inhibitor;innovation;Intervention;Ischemia;ITGAM gene;Laboratories;Learning;Licensing;Life;Link;Liver;liver biopsy;liver function;liver inflammation;liver injury;liver ischemia;Liver neoplasms;liver transplantation;Macrophage;Macrophage Activation;Mediating;Mediator;Messenger RNA;mouse model;Mus;Myelogenous;natural hypothermia;Natural Immunity;novel;Organ;Organ Donor;Organ Transplantation;Outcome;Oxidative Stress;Pathway interactions;Patients;Perfusion;pharmacologic;preconditioning;Predisposition;preservation;programs;Proteins;reconstitution;Recovery;Regulation;Rejuvenation;Reperfusion Injury;Reperfusion Therapy;Repression;Resistance;response;Resveratrol;retransplantation;Signal Transduction;Solid;standard of care;Sterility;Stress;success;synergism;System;Temperature;Testing;Therapeutic;Tissues;Transgenic Model;Translating;transplant model;Transplant Recipients;Transplantation

PROJECT_TITLE: HuR/HIF – SIRT1 Signaling Axis in Liver Transplant Rejuvenation

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rural Health;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: The Wright Regional Center for Clinical and Translational Science (Wright Regional CCTS) is a collaboration of partner institutions that serves regions of Virginia and North Carolina. Partners include Virginia Commonwealth University, Virginia State University, Eastern Virginia Medical School, and Old Dominion University. Our overall goal is to develop methods that overcome roadblocks in clinical and translational science (CTS) to support equitable advancement of translational science across our rural and diverse region that can be deployed throughout the CTSA network.

PI_NAMEs: MOELLER, FREDERICK GERARD (contact)

PROGRAM_OFFICER_NAME: BOUGH, KRISTOPHER J

PROJECT_TERMS: Address;Affect;Agreement;All of Us Research Program;Ambulatory Care;biomedical imaging;clinical center;Clinical Research;Clinical Sciences;Collaborations;Communities;community engaged approach;community engaged research;community engagement;COVID-19;COVID-19 pandemic;Data;data interoperability;Endowment;Epidemic;Equity;ethnic minority population;Ethnic Population;Faculty;Fostering;Funding;Goals;Health;health difference;health disparity;health equity;health equity promotion;Health Personnel;Historically Black Colleges and Universities;Housing;improved;Informatics;Infrastructure;innovation;Institution;Leadership;Low income;Machine Learning;machine learning method;Maps;medical schools;member;Methods;North Carolina;opioid overdose;Outcome;Outcomes Research;participant enrollment;patient population;Patients;Population Heterogeneity;practice-based research network;Process;programs;Protocols documentation;racial minority population;racial population;recruit;Research;Rural;rural patients;Spottings;Techniques;telehealth;timeline;tool;Training;Translational Research;United States National Institutes of Health;Universities;Virginia;vulnerable community;Work;Workforce Development


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Narrative Neuromodulators are important for normal brain function, and defects in modulatory transmission are involved in many brain disorders. We will dissect how the neuromodulator dopamine is released from somata and dendrites from midbrain dopamine neurons in the vertebrate brain. Our results will likely uncover new secretory mechanisms and general principles for neuromodulation, and may reveal cellular pathways that are affected by drugs of abuse.

PI_NAMEs: KAESER, PASCAL SIMON (contact);WILLIAMS, JOHN T

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Ablation;Affect;Architecture;Axon;Behavior;Brain;Brain Diseases;Cells;Characteristics;Cognition;Collection;conditional knockout;Data;Defect;Dendrites;Development;Disease;Dopamine;dopaminergic neuron;Drug Addiction;drug of abuse;Electrophysiology (science);Emotions;Exocytosis;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;Glutamates;Goals;Hot Spot;Image;in vivo;Kinetics;knockout gene;Knockout Mice;Knowledge;Laboratories;Location;Mediating;Membrane;Midbrain structure;Modeling;Molecular;monoamine;motor control;mouse genetics;Movement;Mus;mutant;Mutant Strains Mice;Nerve;Neuromodulator;neuronal excitability;Neurons;Neuropeptides;neuropsychiatric disorder;neuroregulation;neurotransmitter release;neurotrophic factor;Parkinson Disease;Pathway interactions;Phenotype;Protein Family;Proteins;Receptor Activation;Regulation;response;Role;scaffold;Scaffolding Protein;secretory protein;sensor;Signal Transduction;Site;Source;spatiotemporal;Specific qualifier value;Speed;superresolution microscopy;Synapses;synaptotagmin I;Testing;tool;transmission process;Vesicle;Work

PROJECT_TITLE: Mechanisms for somatodendritic dopamine release in the midbrain

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: WILMINGTON

ORG_NAME: NEMOURS CHILDREN'S HOSPITAL, DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE It is essential to address the complex social ecological factors that persistently hamper the delivery of necessary healthcare, particularly in light of pervasive documented health inequities. The REACH (Research Expanding Access to Child Health) Center will strengthen pediatric health care research infrastructure by establishing a thematic, multidisciplinary health research system, rooted in the principles and methods of pediatric healthcare delivery science, and bridging our biomedical research and health care systems to assure equitable access to high quality pediatric health care for all. The REACH Center will propel scientific knowledge, technical capabilities, and clinical practice forward to improve health and health equity for children and families across Delaware with broad implications nationally.

PI_NAMEs: ALDERFER, MELISSA A.;KAZAK, ANNE E (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: access disparities;Address;Biomedical Research;career;career development;Career Mobility;Caring;Centers of Research Excellence;cerivastatin;Characteristics;Child;Child Health;Child health care;Child health equity;Child Support;Childhood;clinical practice;Clinical Research;Clinical Trials Network;Communities;community engagement;community partners;Complex;congenital heart abnormality;Delaware;design;Development;Disadvantaged;Disparity;early life adversity;Ecology;Economic Factors;effective intervention;Enhancement Technology;Ensure;Equity;Ethnic Origin;Evaluation;evidence base;experience;Family;Family health status;Fostering;Funding;Future;Goals;Health;health care availability;health care delivery;Health Care Research;health disparity;health equity;Health equity research;health inequalities;Health system;Healthcare;Healthcare Systems;Housing;Human;improved;Inequity;Infrastructure;innovation;innovative technologies;Institution;International;Intervention;Knowledge;Lead;Leadership;Light;Link;Location;Mentors;Mentorship;Methods;Modeling;multidisciplinary;Names;Obesity;Outcome;Patient-Centered Care;Pediatric Hospitals;Pediatric Research;Personal Satisfaction;Pilot Projects;Population;Prenatal Diagnosis;Principal Investigator;programs;Qualifying;Race;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Rural;Science;Scientist;Services;social;Strategic Planning;Structure;success;System;systems research;Technology;technology intervention;Testing;Training;Translational Research;United States;United States National Institutes of Health

PROJECT_TITLE: Research Expanding Access to Child Health (REACH)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Services;Pediatric;Prevention

PI_NAMEs: KAZAK, ANNE E (contact)

PROJECT_TERMS: Accountability;Achievement;Address;Advisory Committees;Advocate;Biomedical Research;career;career development;Caring;Centers of Research Excellence;cerivastatin;Child;Child Health;Child health care;Communities;Delaware;Doctor of Philosophy;Education;Elements;Ensure;Equity;Evaluation;Event;experience;Faculty;Family;Feedback;Fostering;Funding;Future;Goals;Health;health care availability;health care delivery;Health Care Research;Health Psychology;Health system;Healthcare Systems;Hospitals;Improve Access;Inequity;Infrastructure;innovation;Institution;Intervention;Lead;Leadership;Mentors;Mentorship;Methods;Mission;Monitor;multidisciplinary;operation;Operations Research;Patients;Pediatric Hospitals;Pediatric Research;Performance;Persons;Procedures;Process;Production;Program Development;programs;Provider;recruit;Reporting;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Role;Science;Scientific Evaluation;Site;skills;sound;Strategic Planning;Structure;success;synergism;System;systems research;Technology;technology intervention;Voice


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Lung;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: ATHENS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Narrative Until the unfortunate COVID-19 development, Mycobacterium tuberculosis (Mtb) was the number one cause of death in humans due to a single infectious agent. The current tuberculosis vaccine BCG is very effective in young children, but there is a need for a generally more-effective and longer-lasting vaccine, potentially as a booster to BCG. This proposal examines a novel intranasal subunit BCG booster vaccine comprised of multiple Mtb antigens that interact with the respiratory mucosa and are adhered to nanoparticles and combined with an immune-stimulating matrix.

PI_NAMEs: QUINN, FREDERICK D (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Acceleration;adaptive immune response;Adjuvant;Adsorption;Aerosols;airway epithelium;alveolar epithelium;Animal Model;Animals;Antibodies;Antigen Targeting;Antigen-Presenting Cells;Antigens;Antimycobacterial Agents;Bacille Calmette-Guerin vaccination;Bacillus;Bacteria;Bacterial Adhesins;BCG Live;biophysical properties;Blood Circulation;Blood Screening;booster vaccine;Bronchoalveolar Lavage;C57BL/6 Mouse;Cause of Death;Cavia;CD4 Positive T Lymphocytes;CD8B1 gene;Cells;Child;Chimeric Proteins;Combined Vaccines;COVID-19;cytokine;cytotoxic;cytotoxic CD8 T cells;Dangerousness;Data;delivery vehicle;Development;Diffuse;Disease;Dose;efficacy evaluation;Epithelial Cells;Fluorescence Microscopy;Future;Genes;Glycolates;Goals;granulysin;Granzyme;guinea pig model;heparin-binding hemagglutinin;Histopathology;Human;IL17 gene;Immune;Immune response;Immune system;Immunity;Immunoglobulin A;Immunoglobulin G;Immunologic Stimulation;Immunologics;Immunotherapy;improved;Incubated;Infection;Infectious Agent;Inhalation;Innate Immune Response;Interferons;Link;Lung;Lymphatic;Membrane Microdomains;Microbe;microbial;Microscopic;mucosa-associated lymphoid tissue;Mucosal Immune Responses;Mucosal Immune System;mucosal vaccine;Mucous body substance;Mucous Membrane;Mus;mutant;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;nanoparticle;nanoparticle delivery;nonhuman primate;novel;Organ;pathogen;Pathology;Pattern recognition receptor;perforin;Phase;Predisposition;Preparation;prevent;Production;protective efficacy;protein complex;Protein Secretion;Proteins;recruit;Residual state;Respiratory Mucosa;respiratory pathogen;Respiratory System;response;Route;Safety;safety study;screening;sensor;Signal Transduction;Spleen;subcutaneous;Surface;Temperature;Testing;Th1 Cells;Toxic effect;trafficking;transmission process;Tuberculosis;Tuberculosis Vaccines;uptake;Vaccination;Vaccine Adjuvant;Vaccine Antigen;vaccine safety;Vaccines;VDAC1 gene;Viral;Waxes

PROJECT_TITLE: Novel Nanoparticle Respiratory Tract Mucosal Vaccine


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Social Determinants of Health

PI_NAMEs: CANTER, KIMBERLY  (contact)

PROJECT_TERMS: Accountability;Address;Advisory Committees;Area;Benchmarking;Big Data;Biomedical Research;career;Caring;Child;Child Health;Child health care;Child Welfare;Childhood;Clinical Research;Clinical Trials Network;Complex;Consultations;Dedications;Delaware;Development;disparity reduction;Dissemination and Implementation;effective intervention;Effectiveness;eHealth;Electronic Health Record;Enhancement Technology;Ensure;Equity;Evaluation;experience;Family;Future;Goals;Health;health care availability;health care delivery;health care disparity;health care model;health disparity;health inequalities;Health Personnel;Health Promotion;Healthcare;implementation intervention;Improve Access;improved;Inequity;Infrastructure;innovation;innovative technologies;Internet;Intervention;intervention delivery;Intervention Studies;Investments;Machine Learning;Mentorship;Methodology;Methods;mHealth;Modeling;next generation;Patients;pediatric health outcomes;Pediatric Hospitals;Personal Satisfaction;Population;Procedures;Process;programs;Research;Research Design;Research Infrastructure;Research Personnel;Research Support;research to practice;Resources;Science;social;success;System;Target Populations;Technology;technology intervention;therapy design;therapy development;tool;tool development;Training;Training and Infrastructure;training opportunity;Translational Research;uptake;virtual reality;virtual reality simulation;Youth

PROJECT_TITLE: Intervention Methods: Provision and Connection through Technology (IMPACT)


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Cystic Fibrosis;Genetics;Hematology;Infectious Diseases;Lung;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative: STAT3 mutations cause autosomal dominant hyper IgE syndrome (AD-HIES), a rare genetic disease. Recurrent pulmonary infection is the leading cause of mortality in AD-HIES, but the mechanism(s) mediating mutant STAT3-induced lung disease are unclear. This application proposes to identify the mechanisms by which STAT3 mutations cause defective mucociliary clearance in AD-HIES subjects, quantitate their mucus obstruction and ventilation defects, and provide options for new therapies for the pulmonary manifestations of AD-HIES.

PI_NAMEs: BOUCHER, RICHARD CHARLES (contact);CHEN, GANG

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Adenosine;Air;airway epithelium;Alternative Therapies;Atelectasis;Attention;autosome;Bacterial Infections;Bone Marrow;bronchial epithelium;Case Study;Cell Culture Techniques;Cell Differentiation process;Cell Physiology;Cells;Characteristics;Chlorides;Chronic;chronic infection;Cilia;cilium motility;clinical center;Clinical Trials;congenital immunodeficiency;CRISPR/Cas technology;Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Defect;defense response;Development;Dominant-Negative Mutation;Dynein ATPase;ectoATPase;Eczema;Elements;Eosinophilia;Epithelial Cells;epithelial repair;Etiology;Exhibits;Exposure to;Extramural Activities;Failure;Frequencies;Gases;Genes;Genetic Transcription;Goals;Hematopoietic Stem Cell Transplantation;High Resolution Computed Tomography;Host Defense;Human;Hydration status;Hyper-IgE Syndrome;IgE;Image;imaging modality;Imaging Techniques;immune reconstitution;Impairment;improved;In Vitro;in vitro activity;in vitro Assay;in vitro testing;in vivo;Infection;Infectious Skin Diseases;Inflammation;Inflammatory;inhibitor;injury and repair;Institution;Intramural Research Program;Ions;Job's Syndrome;Lung;Lung Diseases;Lung infections;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Medical center;Metabolic Clearance Rate;microCT;Modality;Molecular;Morbidity - disease rate;mortality;Motor Activity;Mucociliary Clearance;Mucous body substance;Mucous Membrane;mucus clearance;mutant;Mutation;Mycoses;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;Nose;novel;novel therapeutics;Obstruction;overexpression;Pathogenesis;Pathway interactions;Patients;Pattern;Performance;Phenotype;Physiological;Pneumonia;Primary Ciliary Dyskinesias;Procedures;Property;quantitative imaging;Rare Diseases;rare genetic disorder;reconstitution;Recurrence;Regulation;Resistance;respiratory imaging;Risk;Role;Saline;small molecule;STAT3 gene;Stimulus;Surface;Survivors;System;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;therapeutic evaluation;Thick;transcription factor;Transgenic Mice;ultra high resolution;United States National Institutes of Health;ventilation;Viscosity;Water;X-Ray Computed Tomography

PROJECT_TITLE: The molecular and cellular mechanisms of the STAT3 mutation-mediated pulmonary disorder in Autosomal Dominant Hyper IgE Syndrome (AD-HIES)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: CUTULI, JOSEPH J (contact)

PROJECT_TERMS: Accountability;Address;Adoption;Advisory Committees;Advocate;Area;base;Belief;Biomedical Research;career;Caring;Centers of Research Excellence;Child;Child Health;Child health care;Child Welfare;Childhood;Clinical Research;Clinical Trials Network;Collaborations;Communities;community based participatory approach;community engaged research;community engagement;Community Health;Community Outreach;Community Participation;community partnership;community research;Complex;Consultations;data repository;Data Set;Delaware;Disadvantaged;Ecology;Ensure;Equity;Family;Fostering;Funding;Generations;Goals;Health;health disparity;health inequalities;Healthcare;Healthcare Systems;improved;Income;Individual;Inequity;Infrastructure;innovation;Institution;Intervention;Investigation;Investments;Knowledge;Leadership;meetings;member;Methods;Modeling;operation;outreach;Participant;Pediatric Hospitals;Pediatric Research;Peer Review;Phase;Policies;Positioning Attribute;Process;programs;Provider;Public Policy;Publications;racial disparity;Reporting;Research;research in practice;Research Personnel;Research Priority;Research Support;Resources;response;Route;Secure;social;success;Time;tool;Training;Translating;Translational Research;Trust;Work;working group

PROJECT_TITLE: Pediatric Research Optimizing Methods in Stakeholder Engagement (PROMISE)


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The research experiences, education, and mentorship skills training of researchers from low- and middle- income countries in this program will allow them to more independently address the most important issues of global HIV prevention, and with greater effectiveness by taking into account the local context and culture. ITAPS will help address critical shortages of trained LMIC mentors and fill gaps in analytic skills required for research. Mutually beneficial research collaborations between US investigators and ITAPS trainees will be promoted.

PI_NAMEs: LINDAN, CHRISTINA P (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;AIDS prevention;Applied Research;Applied Skills;Awareness;Biometry;California;career;catalyst;Cognitive;cohort;Collaborations;Country;Data;Data Analyses;data management;Degree program;design;Development;Distance Learning;Education;education research;Educational workshop;effective intervention;Effectiveness;Elements;Enrollment;experience;Faculty;Fostering;fundamental research;Goals;HIV;HIV Infections;Home;human capital;Human immunodeficiency virus test;Incidence;Income;innovation;Institution;interdisciplinary approach;International;investigator training;Journals;Learning;low and middle-income countries;Manuscripts;Mentors;Mentorship;Modeling;National Institute of Mental Health;peer networks;Peer Review;Persons;Prevalence;prevent;Prevention;Prevention program;Prevention Research;Prevention strategy;preventive intervention;Productivity;programs;Publications;Publishing;Research;Research Methodology;Research Personnel;Research Priority;Research Proposals;Research Support;Research Training;San Francisco;Scientist;skill acquisition;skills;skills training;social;social capital;Structure;success;theories;Traineeship;Training;Training Programs;Training Support;Universities;Writing

PROJECT_TITLE: International Traineeships in AIDS Prevention Studies (ITAPS)


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Pediatric;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

PI_NAMEs: PHAN-VO, THAO-LY TAM (contact)

PROJECT_TERMS: 12 year old;Academy;Address;Affect;American;Area;Behavior;behavior change;Behavior Therapy;Body System;Cardiovascular Diseases;Caring;Child;Child Health;Childhood;Clinical;Color;Communities;Community Healthcare;Community Integration;community organizations;community partners;community-centered;community-level factor;Complex;Counseling;Diabetes Mellitus;Disparity;disparity reduction;effectiveness testing;efficacy evaluation;Electronic Health Record;empowerment;Enhancement Technology;Ensure;ethnic minority population;Ethnic Origin;evidence base;Face;Family;family management;Feedback;Food;Foundations;Friends;Health;health care quality;Healthcare;Healthcare Systems;Home environment;improved;Inequity;innovative technologies;integrated care;Intervention;intervention refinement;Life Style;Low income;low socioeconomic status;Measures;member;Mental Health;mobile application;Modeling;multi-component intervention;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;Nutritional;Obesity;obesity in children;obesity treatment;Outcome;Parents;patient centered medical home;Pediatrics;Physical activity;primary care practice;primary care provider;primary care setting;primary care visit;psychoeducation;psychosocial;Public Health;Qualitative Research;Quality of Care;Race;racial minority population;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Research;Research Methodology;Resources;Risk;Role;Rural;Rural Community;rural underserved;Self Management;Site;Social Work;Socioeconomic Status;Specialist;standard care;success;Technology;telehealth;Testing;tool;Transportation;Treatment outcome;United States;usability;Work

PROJECT_TITLE: MICCO - Mobile Integrated Care for Childhood Obesity: A technology-enhanced comprehensive approach to integrating obesity care in rural communities


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Congenital Heart Disease;Congenital Structural Anomalies;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Telehealth;Women's Health Research

PI_NAMEs: SOOD, ERICA D (contact)

PROJECT_TERMS: Address;Affect;Anxiety;Behavior Therapy;Behavioral Model;Behavioral Research;biological adaptation to stress;Birth;Black race;Brain;burden of illness;Cardiac Surgery procedures;Cardiology;Caring;Child;Child Health;Child Rearing;clinically significant;comparison intervention;Congenital Abnormality;congenital heart abnormality;Decision Making;design;Development;Developmental Delay Disorders;Disease;Distress;Education;efficacy trial;Elements;emotional distress;Ethnic Origin;Ethnic Population;Evaluation;Exhibits;Family;Feedback;fetal;Fetal Heart;Fetus;follow-up;Funding;Health system;Hispanic;hospital readmission;Hospitalization;Hospitals;improved;in utero;Infant;innovation;Intervention;intervention refinement;Low income;maternal stress;Measures;Medical;Mental Depression;Modeling;Morbidity - disease rate;Mothers;multidisciplinary;National Heart, Lung, and Blood Institute;Operative Surgical Procedures;Outcome;Outcome Assessment;Outcomes Research;Parents;Participant;Patient-Focused Outcomes;Patients;Personal Satisfaction;Phase;pilot test;Population;post intervention;postnatal;Pregnancy;Pregnant Women;prenatal;Prenatal Diagnosis;prenatal experience;provider communication;psychosocial;Race;racial population;Randomized;Randomized, Controlled Trials;recruit;Research;Self Efficacy;Severities;Site;Social isolation;socioeconomics;Spanish/English;standard care;Stress;Structure;telehealth;Testing;therapy development;Time;tool;Trauma;traumatic stress;Underserved Population;usability;virtual delivery;Vulnerable Populations;Well in self;Work

PROJECT_TITLE: HeartPREP: A virtually-delivered psychosocial intervention for mothers expecting a baby with congenital heart disease


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  Understanding the molecular mechanisms underlying the infectivity of Mycobacterium tuberculosis expands our knowledge of biochemical pathways in pathogenic bacteria and is crucial to identify novel targets with the hope of combating the increase in drug-resistant strains. We are studying unique aspects of both gene regulation and DNA repair in M. tuberculosis. In separate studies, we are using ensemble biochemistry, single-molecule biophysics, and kinetic modeling to undercover the mechanisms of transcription initiation in Eukaryotes, including yeast and humans.

PI_NAMEs: GALBURT, ERIC A (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Antibiotics;Binding Sites;Biochemical Pathway;Biochemistry;biological adaptation to stress;biophysical model;Biophysics;Cessation of life;Complex;Coupled;Dependence;Development;DNA;DNA Repair;DNA Sequence;DNA-Directed RNA Polymerase;Drug resistance;Escherichia coli;Eukaryota;experimental study;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Genus Mycobacterium;Health;Human;Human Biology;human pathogen;Infection;interest;Intuition;Investigation;Isomerism;kinetic model;Kinetics;Knowledge;Link;Magnetism;Mismatch Repair;Molecular;Mycobacterium tuberculosis;Nature;novel;Nucleotide Excision Repair;Organism;pathogenic bacteria;Pathway interactions;Phase;Process;promoter;recruit;repair enzyme;repaired;Research;resistant strain;Resolution;Role;Sigma Factor;single molecule;transcription factor;transcription factor TFIIH;Transcription Initiation;Transcription Initiation Site;Transcription-Coupled Repair;Transcriptional Regulation;Tuberculosis;Work;Yeasts

PROJECT_TITLE: Molecular Mechanisms of Transcription Initiation and DNA Repair

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: ALDERFER, MELISSA A.;ENLOW, PAUL  (contact)

PROJECT_TERMS: acceptability and feasibility;Acute;Black race;Caregivers;Case Manager;Child Health;Clinic Visits;Complex;Continuous Glucose Monitor;Diabetes Mellitus;digital;Disparity;disparity reduction;Educational Materials;efficacy testing;Enhancement Technology;Equity;experience;Family;glycemic control;Glycosylated hemoglobin A;Health;Health Personnel;Hispanic;improved;Insulin-Dependent Diabetes Mellitus;Intervention;Journals;Measurement;Mentors;Mentorship;Outcome;patient-clinician communication;Patients;peer;pilot test;primary outcome;programs;Randomized;Randomized, Controlled Trials;recruit;Reduce health disparities;Research;Schedule;screening;Site;System;Technology;Testing;Time;Training;Treatment Efficacy;Treatment Protocols;Waiting Lists;Work;Youth

PROJECT_TITLE: Tech-Ex: A Peer Mentorship Program to Increase Equitable use of Continuous Glucose Monitoring Systems


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: The purpose of this study is to test VALE+TU SALUD (Your Health is Worth More) in a cluster randomized trial in order to answer this question: Can an adapted Latino day laborer program increase adherence to mitigation practices that reduce the risk of COVID 19? We will implement, test, and evaluate this program at day labor corners and if successful, we will disseminate its results among Latino day laborers and other Latino immigrant workers.

PI_NAMEs: FERNANDEZ-ESQUER, MARIA EUGENIA (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Acute;Address;Adherence;Adopted;Adoption;base;bed capacity;Central America;Cluster randomized trial;community advisory board;community intervention;community organizations;County;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 prevention;COVID-19 risk;COVID-19 vaccine;Crowding;current pandemic;Dangerousness;Economics;Educational Curriculum;Effectiveness;Equation;Equipment;Ethnic Population;evidence base;Exposure to;Goals;Handwashing;Health;health disparity populations;Hospitalization;Immigrant;Immigrant worker;infection rate;Injury;Intervention;intervention mapping;Latino;Latino Population;Life;member;men;Mexico;Modeling;Needs Assessment;Occupations;pandemic disease;pandemic impact;pandemic stressor;Patient Recruitments;Patients;personal protective equipment;Phase;portability;post intervention;prevent;Prevention program;Problem Solving;programs;Random Allocation;randomized trial;Reporting;Research;Resources;response;Risk;Risk Reduction;SARS-CoV-2 positive;Secure;Services;Site;Social Distance;social media;socioeconomics;stressor;Surveys;Testing;Texas;Time;United States National Institutes of Health;Vulnerable Populations;Work

PROJECT_TITLE: VALE+TU SALUD: CORNER-BASED RANDOMIZED TRIAL TO TEST A LATINO DAY LABORER PROGRAM ADAPTED TO PREVENT COVID 19

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-W(56)R]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: HUMACAO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF PUERTO RICO AT HUMACAO

ORG_STATE: PR

PHR: PROJECT NARRATIVE  The Undergraduate Research Training Initiative for Student Enhancement (U-RISE) Program of the University of Puerto Rico at Humacao will increase the number of underrepresented minority students that will pursue graduate studies in the Biomedical Sciences. This will contribute to diversify the nation’s biomedical research workforce. We will accomplish our goal by providing our students with intensive research training, critical thinking development, communication skills development, interpersonal skills development, and preparation for entrance to graduate school.

PI_NAMEs: MALAVE, TANIA M (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: academic preparation;Admission activity;Advisory Committees;Area;Biochemistry;Biomedical Research;Biophysics;Cancer Biology;career;CCL7 gene;Cellular biology;Communication;Community Outreach;Competence;Computer Analysis;Critical Thinking;design;Development;Developmental Biology;Discipline;Doctor of Medicine;Doctor of Philosophy;Educational Curriculum;Educational workshop;Enrollment;Evaluation;experience;Feedback;Funding;Goals;graduate school;Grant;Journals;Measurable;Mentorship;Microbiology;minority undergraduate;Neurosciences;Organic Chemistry;Paper;Participant;peer;Peer Review;Preparation;programs;Publications;Puerto Rico;Research;Research Training;Scheme;Science;skills;Students;Suggestion;Talents;Training;undergraduate student;Universities;Work

PROJECT_TITLE: U-RISE at the University of Puerto Rico at Humacao

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Vascularization is critical to many normal (e.g., wound healing) and pathologic (e.g., tumor progression) conditions, as well as emerging therapeutic approaches to treat ischemic diseases. This proposal will determine how two key features of the microenvironment (the extracellular matrix and supporting stromal cells) regulate the quantity, functional quality, and stability of new capillary blood vessels. Results from the proposed studies will help bring cell/biomaterial-based strategies to vascularize tissues closer to a translational endpoint.

PI_NAMEs: PUTNAM, ANDREW J (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;Address;Affect;Automobile Driving;Biocompatible Materials;Biological Models;biophysical properties;Blood capillaries;Blood Vessels;Bone Marrow;Capillary Permeability;cell type;Cells;Chronic;Clinical Trials;Coculture Techniques;critical limb Ischemia;Data;Disease;Elasticity;Elements;Encapsulated;Endothelial Cells;Engineering;Extracellular Matrix;Fiber;Fibrin;Fibroblasts;Funding;Gel;Goals;Hares;Hydrogels;improved;In Vitro;in vivo;in vivo Model;insight;Intercellular Junctions;Intramuscular Injections;intravenous injection;Ischemia;Laboratories;Length;Limb Salvage;Link;Literature;Mechanics;Mediating;Microfluidics;Modeling;Modulus;Morphogenesis;neovascularization;neovasculature;Pathologic;Pathology;Peer Review;Perfusion;Permeability;Pre-Clinical Model;Predisposition;progenitor;Publications;Publishing;Regenerative Medicine;revascularization;Rheology;Role;Site;spatiotemporal;Speed;Stress;Stromal Cells;Structure;success;Therapeutic;therapeutic angiogenesis;three dimensional cell culture;Time;Tissue Engineering;Tissues;tool;tumor progression;Turtles;Vascular Permeabilities;vascular tissue engineering;Vascularization;wound healing

PROJECT_TITLE: Microenvironmental Control of Capillary Morphogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-R(02)M]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Infectious Diseases;Racial and Ethnic Minority Health Research;Rare Diseases;Sickle Cell Disease

ORG_CITY: WASHINGTON

ORG_NAME: HOWARD UNIVERSITY

ORG_STATE: DC

PHR: The proposed research is relevant to public health and specifically minority health and health disparities because it is aimed at understanding the molecular mechanism of HIV-1 infection in patients with Sickle Cell Disease. The proposed research is relevant to the NIH mission that pertains to a reduced disparities and vulnerability of the minority population to chronic diseases that include HIV-1 infection.

PI_NAMEs: NEKHAI, SERGEI  (contact)

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: Abnormal Hemoglobins;Affect;Africa South of the Sahara;African;African American population;African American Women;Alleles;Anti-viral Response;arm;Case/Control Studies;CD8B1 gene;CDK2 gene;Cells;Chronic;Chronic Disease;Clinic;cohort;Data;Development;disparity reduction;dual diagnosis;Erythrocytes;Fetal Hemoglobin;Frequencies;Gene Expression;Genes;Genetic Transcription;Globin;Grant;Hematology;Heme;Hemoglobin;Hemoglobinopathies;Hemolysis;Hemolytic Anemia;Hepatic;hepcidin;HIV;HIV-1;HLA-B Antigens;Human immunodeficiency virus test;Hypoxia;in vivo;Individual;Infection;infection rate;inflammatory marker;Inherited;Innate Immune Response;Interferon alpha;Interferon-beta;Interferons;Iron;Iron Chelation;iron metabolism;Low Prevalence;Macrophage;male;Measures;Mediating;metal transporting protein 1;Minority Groups;minority health;minority health disparity;Mission;Molecular;monocyte;mouse model;Mus;Mutation;Nigerian;novel;overexpression;Participant;Patient Recruitments;Patients;Peptides;Peripheral Blood Mononuclear Cell;Persons;Phosphorylation;Phylogeny;prevent;Production;Protein Dephosphorylation;Protein Export Pathway;Proteins;Public Health;Race;Research;Reverse Transcription;Risk;screening;Sickle Cell;Sickle Cell Anemia;Sickle Cell Trait;Sickle Hemoglobin;sickling;T-Lymphocyte;Testing;The Multicenter AIDS Cohort Study;Therapeutic;trait;transcriptome sequencing;TRIM Gene;United States National Institutes of Health;Universities;Up-Regulation;Viral;Viral Load result;Virus;Woman

PROJECT_TITLE: Sickle Cell Disease and Sickle Cell Trait Protection Against HIV-1-infection in Africans and African Americans

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Social Determinants of Health;Violence Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Prolonged social isolation can produce deleterious effects on the brain and behavior, including the promotion of interpersonal aggression and violence against others. The proposed research is relevant to public health, as we aim to achieve a circuit-based, mechanistic understanding of how the brain exerts coordinated, prefrontal control of isolation-induced aggression. These findings will transform the field by expanding our understanding of how pathological forms of aggression are encoded by the brain, and will identify targets for the treatment of isolation- related mental health disorders, particularly those that result in violence.

PI_NAMEs: ZELIKOWSKY, MORIEL  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Aggressive behavior;aging population;attenuation;Behavior;behavior test;Biological Assay;Brain;Brain region;Cells;cognitive control;Cognitive Therapy;Color;Coupled;COVID-19 pandemic;Data;Development;Domestic Violence;Endoscopy;Epidemic;gain of function;gamma-Aminobutyric Acid;gene function;hippocampal pyramidal neuron;House mice;Housing;Hypothalamic structure;Image;in vivo;Interneurons;Lead;Loneliness;loss of function;Machine Learning;Medial;Mediating;Mediator;Mental disorders;Modernization;Molecular Genetics;Mus;neural;neural patterning;Neurokinin B;Neuromedin K Receptor;Neurons;Neuropeptides;Obesity;opioid epidemic;optogenetics;Pathologic;Perception;poor health outcome;Population;Prefrontal Cortex;Public Health;Research;Risk Factors;Role;school shooting;Signal Transduction;Smoking;social;social contact;Social Controls;social deprivation;social group;Social isolation;social media;social structure;Socialization;Societies;suicide rate;System;Tachykinin;Technology;Testing;Textiles;Therapeutic Intervention;Violence

PROJECT_TITLE: Prefrontal Circuit Control of Isolation-Induced Aggression

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Rural Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: THOMPSON, HILAIRE J (contact)

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: Alaska;Area;career;career development;cohort;Collaborations;Competence;Consultations;Development;Development Plans;Discipline;Disclosure;E-learning;Education;Educational Curriculum;Educational Models;Emerging Communicable Diseases;Ensure;experience;Faculty;Funding;Hybrids;Idaho;Individual;Institution;Institutional Review Boards;Intellectual Property;Interdisciplinary Study;Joints;Learning;Link;Mentors;Montana;National Research Service Awards;next generation;Phase;pre-doctoral;predoctoral investigator;programs;Protocols documentation;real world application;Recording of previous events;Research;Research Project Grants;Resources;Rural health equity;Rural Population;Scientist;Services;Site;skills;strength training;Students;Supervision;TNFSF15 gene;Training;Training Programs;translational health science;Translational Research;translational scientist;Tribal group;Universities;virtual;Washington;Wyoming

PROJECT_TITLE: NRSA Training Core


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Narrative The objective of this proposal is to develop an efficient, non-viral CRISPR approach to generate cardiovascular progenitor cells from somatic fibroblasts. The results will reveal the mechanistic role of endogenous gene activation and long non-coding RNAs in cell reprogramming, develop new cell fate tracking system, and provide a new regeneration therapy for the infarcted myocardium.

PI_NAMEs: LIANG, JIALIANG ;WANG, YIGANG  (contact)

PROJECT_TERMS: Ablation;Address;adverse outcome;Biological;Bypass;Cardiac;Cardiac Myoblasts;cardiac regeneration;cardiac repair;Cardiovascular Diseases;Cardiovascular system;Cause of Death;cell regeneration;Cell Reprogramming;Cell Therapy;Cells;Chromatin;Cicatrix;Clinical;Clonality;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complex;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Data;design;Development;dosage;Effectiveness;Embryo;Embryonic Heart;Engraftment;Ensure;Enzymes;Epigenetic Process;experimental study;Feedback;Fibroblasts;Fostering;functional restoration;GATA4 gene;Gene Activation;gene network;Generations;Genes;Genetic;Genetic Transcription;genome editing;genomic locus;Genotype;heart function;Heterogeneity;histone methyltransferase;Histones;imaging approach;Implant;implantation;improved;in vivo imaging;induced pluripotent stem cell;Infarction;Insertional Mutagenesis;Investigation;lentivirally transduced;Mediating;Mediator;MLL gene;Modeling;Molecular;Mus;Myocardial Infarction;Myocardial Ischemia;Myocardium;Natural regeneration;neovascularization;next generation sequencing;Oncogenic;Outcome;overexpression;Phenotype;pluripotency;pre-clinical;Process;Property;regenerative;regenerative therapy;Regulation;repaired;Research;Ribonucleoproteins;RNA-Protein Interaction;Role;Safety;screening;Selection for Treatments;self-renewal;Somatic Cell;Source;Stem Cell Development;stem cell genes;stem cells;System;Techniques;Technology;Therapeutic;Tissue Engineering;tool;trait;Transcript;transcription factor;translational study;Translations;Transplantation;Treatment Efficacy;Tumorigenicity;Undifferentiated;Untranslated RNA;vector

PROJECT_TITLE: CRISPR-induced cardiovascular progenitor cells to repair myocardial infarction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MIM-R(01)]


ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Narrative The Baylor College of Medicine Short-Term Research Education Program to Enhance Diversity in Health-Related Research (BCM STREPED) will mentor undergraduates who are underrepresented (UR) in science and medicine in research-intensive biomedical training in mission areas of the National Heart, Lung, and Blood Institute, related to the causes, prevention, diagnosis, and treatment of heart, blood vessel, lung, and blood diseases, and sleep disorders. The BCM STREPED trainees will participate in the BCM SMART summer undergraduate research program to develop knowledge and skills and become better prepared to enter advanced biomedical research training and careers to enhance the diversity representation in the biomedical, behavioral, and clinical research workforce.

PI_NAMEs: BORIEK, ALADIN M (contact);PEREIRA, FRED A;RICE, ANTONIE H.

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Academia;Address;Area;base;Behavioral Research;Biomedical Research;Blood;Blood Vessels;Cancer Education Grant Program;career;Clinical Research;college;Communication;Communities;Computational Technique;Critical Thinking;Development;Diagnosis;Disease;Doctor of Philosophy;education research;Educational Curriculum;Educational workshop;Evaluation;experience;Extramural Activities;Faculty;faculty mentor;formative assessment;Fostering;Funding;Goals;graduate school;Grant;Health;Health Occupations;Health Professional;Healthcare;Heart;Hematological Disease;Hospitals;human capital;Image;improved;innovation;interest;Knowledge;Laws;Leadership;Learning;Literature;Lung;Lung Diseases;Medical;medical schools;Medicine;member;Mentors;Mentorship;Mission;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Oral;Outcome;Participant;peer;Physicians;Population;posters;Prevention;programs;recruit;Reporting;Reproducibility;Research;Research Training;responsible research conduct;role model;satisfaction;Science;Scientific Evaluation;Scientist;skills;Sleep Disorders;STEM career;Students;success;Surveys;symposium;Technology;Tissue Engineering;Training;Training Programs;Translational Research;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Vocational Guidance;volunteer;Writing

PROJECT_TITLE: Short-Term Research Education Program to Increase Diversity in Health-Related Research (STREPID)


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Contraception/Reproduction;Neurosciences;Osteoporosis;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Drugs that reduce the activity of an enzyme called phosphodiesterase 5A (PDE5A) are used worldwide as safe and efficacious agents for erectile dysfunction in older men, in men with diabetes, and in men with prostate cancer following therapy. Our recent finding in mice that the drugs also increase bone mass, particularly in females, has prompted our current investigations into their efficacy and mechanism of action. These preclinical studies, comprising both genetic and pharmacological approaches, should provide the basis for future clinical trials for osteoporosis in elderly women and men.

PI_NAMEs: KIM, SE-MIN ;YUEN, TONY  (contact);ZAIDI, MONE

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: 1 year old;Acute;aged;Aging;androgen deprivation therapy;Biological Assay;bone;bone cell;Bone Density;Bone Formation Stimulation;bone loss;bone mass;Bone remodeling;Bone Resorption;Bone Resorption Inhibition;Brain;Brain region;Cells;cellular targeting;Clinical Trials;Cyclic GMP;Cyclic GMP-Dependent Protein Kinases;Diabetes Mellitus;drug action;drug repurposing;efficacy study;Elderly;Elderly man;Elderly woman;enzyme activity;Enzymes;Erectile dysfunction;Excision;FDA approved;Female;Foundations;Future;gain of function;Genetic;genetic signature;Goals;Hormones;Human;Hypogonadism;inhibitor;Investigation;knock-down;Knockout Mice;locus ceruleus structure;loss of function;male;Malignant neoplasm of prostate;Maps;Mediating;Memory;men;mineralization;Modeling;Molecular;Monitor;Mus;nerve supply;neural;neurogenesis;Neurons;Nitric Oxide;NOS3 gene;older men;Oral;osteoblast differentiation;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis;Osteopenia;Osteoporosis;ovarian failure;Ovariectomy;overexpression;paraventricular nucleus;Pathway interactions;Peripheral;Pharmaceutical Preparations;pharmacologic;Phenocopy;Phosphodiesterase Inhibitors;phosphoric diester hydrolase;Population;Positive Lymph Node;preclinical efficacy;preclinical study;prevent;Prevention;Production;Prostate Cancer therapy;Protein Isoforms;Pulmonary Hypertension;Rattus;Reporting;Rodent Model;Role;Safety;sildenafil;Site;skeletal;small molecule inhibitor;Structure;Surface;tadalafil;Time;Tracer;Transcript;Translations;vardenafil;Virus;Wild Type Mouse;Withdrawal;Woman;Work

PROJECT_TITLE: Proof-of-Concept and Mechanistic Studies to Repurpose Erectile Dysfunction Drugs for Elderly Females

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: PROJECT NARRATIVE Declines in physical and cognitive function with aging leads to higher risk for the loss of independence in older adults. Ways to improve both physical and cognitive function would be invaluable to maintain quality of life in older adults. MitoQ treatment may represent a novel therapeutic intervention that can improve physical and cognitive performance through decreasing reactive oxygen species in older at-risk adults.

PI_NAMEs: KWON, OH SUNG  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Address;Adult;Aging;aging related;Agreement;Alzheimer's Disease;Animal Model;animal old age;Antioxidants;Atherosclerosis;Attenuated;Biological;Biological Aging;Biological Availability;Biological Markers;Blood Flow Velocity;Blood Vessels;Brain;Cardiovascular Diseases;Cardiovascular Physiology;cardiovascular risk factor;cerebral hypoperfusion;cerebrovascular;Cerebrovascular system;Cerebrum;Chronic;Chronic Disease;Clinical;Clinical Trials;Cognitive;cognitive enhancement;cognitive function;cognitive performance;Collaborations;Custom;Data;Dementia;design;disability;Disease;effective intervention;effective therapy;Elderly;Endothelium;Exercise;Exercise Physiology;experience;Frail Elderly;functional independence;functional outcomes;Funding;Future;Gait speed;Geroscience;Goals;hallmarks of aging;healthspan;high risk;Homeostasis;Human Resources;Hypertension;Impairment;improved;Individual;investigator training;Learning;Measurement;Measures;Mediating;Memory;Metabolic;middle cerebral artery;mild cognitive impairment;Mitochondria;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;multidisciplinary;Nitric Oxide;novel therapeutic intervention;older adult;Perfusion;Peripheral;peripheral blood vessel;Phase;Physical Function;Physical Performance;Physiological;Play;prevent;Quality of life;Reactive Oxygen Species;Regulation;Research;Research Design;Research Personnel;Research Training;response;Risk;Risk Factors;Role;Science;Site;skills;Source;Supplementation;Time;Training;Training and Education;Trust;United States National Institutes of Health;Vascular Dementia;Vascular Endothelium;Vasodilation;walker;Walking;walking speed

PROJECT_TITLE: The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: NARRATIVE Pulmonary nontuberculous mycobacterial disease is increasing in incidence and disproportionately affects the elderly. However, the mechanisms underlying increased vulnerability and disease severity in the elderly are unknown. Therefore, in this proposal we will identify these mechanisms by investigating age related changes in immunity and microbial communities in the lung using a translational nonhuman primate model.

PI_NAMEs: MESSAOUDI, ILHEM  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Acute Disease;Affect;Age;age difference;age effect;age related;age related changes;Age Years;Aged, 80 and over;Aging;aging population;American;Animal Diseases;Antibiotic Therapy;Antibiotics;Antibodies;Area;Biological Assay;Biology;Cells;Censuses;Chronic;Chronic Disease;Chronic lung disease;clinical care;Communities;Coupled;cytokine;Cytokine Gene;Defect;Development;Disease;disorder prevention;disorder risk;Elderly;Environment;exposed human population;Female;Genetic Transcription;genome wide association study;Genomics;Genus Mycobacterium;Health;human old age (65+);Immune;immune activation;Immune response;Immunity;Immunologics;Immunology;Immunology procedure;improved;Incidence;Individual;Infection;inflammatory marker;inhibitor;insight;Interferon Type II;Interleukin-12 Gene;juvenile animal;Kinetics;Lead;Life;Lower respiratory tract structure;Lung;Lung Diseases;Lung infections;lung microbiome;lung microbiota;Macaca mulatta;mathematical model;Mediating;microbial community;microbiome;Modeling;Morbidity - disease rate;Mucociliary Clearance;Mutation;Mycobacterium avium;Mycobacterium avium Complex;Mycobacterium avium-intracellulare Infection;Mycobacterium Infections;Mycobacterium tuberculosis;next generation sequencing;non-tuberculosis mycobacteria;nonhuman primate;novel;Older Population;Oral;pathogen;Pathogenesis;pathogenic bacteria;Patients;Peripheral Blood Mononuclear Cell;Physiological;Play;Population;Predisposition;Prevalence;probiotic therapy;Prospective Studies;pulmonary function;Pulmonology;Relapse;Research;respiratory microbiome;response;Risk;Role;Severities;Severity of illness;Statistical Models;Structure;T-Lymphocyte;Testing;TNF gene;Tuberculosis;United States;Upper respiratory tract;virtual

PROJECT_TITLE: Mechanisms of increased susceptibility to pulmonary Nontuberculous Mycobacterial disease in the elderly

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-R(03)]


PHR: PROJECT NARRATIVE This R50 Research Specialist (Clinical Scientist) proposal is to support (40% effort) Deborah Stephens, DO, to continue providing extensive support of NCI-sponsored clinical trials including: serving as a national principal investigator for the S1925 EVOLVE CLL trial; supporting SWOG Leukemia and Lymphoma Working Groups; and, providing leadership and mentorship in hematology clinical trials research at Huntsman Cancer Institute. Dr. Stephens’s work as a clinical investigator focuses on improving survival and care of patients with chronic lymphocytic leukemia and relapsed/refractory B-cell lymphoma, the most common adult blood cancers which are mostly considered incurable. This Research Specialist award would improve the survival of and care for these patients and support Dr. Stephens continued development and management of a clinical trial portfolio with significant scope at HCI including National Cancer Institute (NCI)-sponsored investigator-initiated, and industry-sponsored clinical trials.

PI_NAMEs: STEPHENS, DEBORAH  (contact)

PROGRAM_OFFICER_NAME: TAWAB-AMIRI, ABDUL

PROJECT_TERMS: Adult;Advisory Committees;Advocate;Award;B-Cell Lymphomas;Caring;Catchment Area;Chronic Lymphocytic Leukemia;Clinical;clinical investigation;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;Community Health Education;Community Outreach;Dedications;Development;Early Therapeutic-Clinical Trials Network;Fellowship;fighting;Funding;Grant;Hematological Disease;Hematology;Hematopoietic Neoplasms;improved;Industry;International;investigator-initiated trial;Kentucky;Lead;Leadership;leukemia;leukemia/lymphoma;Longterm Follow-up;Lymphoma;Malignant Neoplasms;Mantle Cell Lymphoma;meetings;member;Mentorship;National Cancer Institute;Ohio;Outcome;Patient Care;patient navigation;Patients;Phase I/II Clinical Trial;Physicians;Principal Investigator;professor;programs;Protocols documentation;Publishing;recruit;Refractory;Relapse;Research;Research Institute;Research Personnel;Research Scientist Award;Review Committee;Role;Scientist;Small-Cell Lymphoma;Southwest Oncology Group;Specialist;standard of care;Therapeutic;therapy resistant;Time;Translations;Underrepresented Minority;Universities;Woman;Work;working group

PROJECT_TITLE: Curing Through Collaboration: Utilizing Cooperative Groups in the Fight Against Chronic Lymphocytic Leukemia and B-cell Lymphomas


NIH_SPENDING_CATS: Biotechnology;Cancer;Neurosciences

ORG_NAME: GEORGETOWN UNIVERSITY

PHR: EAG channels are key regulators of neuronal excitability and tumor progression. Defects in EAG channel function are associated with neurological diseases and cancer. Our goal is to determine the mechanisms of EAG channel regulation by intracellular ligands and to test therapeutic potential of this regulation for treatment of cancer.

PI_NAMEs: BRELIDZE, TINATIN I (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Adverse effects;Affect;Antibodies;Apoptosis;Binding;Binding Sites;Brain;C-terminal;Cancer cell line;cancer therapy;Cellular biology;Chemicals;clinically relevant;Computer Simulation;Computing Methodologies;Cyclic Nucleotides;cytotoxicity;Defect;Development;Disease;drug development;Drug Targeting;Electrodes;Electrophysiology (science);Embryo;Ethers;experience;experimental study;FDA approved;Geometry;Goals;Growth;Human;Implant;Individual;inhibitor;innovation;Knock-out;Laboratories;Learning;Ligand Binding;Ligands;Link;Malignant Neoplasms;malignant neurologic neoplasms;Maps;Methods;migration;Molecular;Molecular Mechanisms of Action;Monitor;Mus;Mutation;N-terminal;Neoplasm Metastasis;neoplastic cell;Nervous System Disorder;neuronal excitability;neuronal tumor;Neurons;novel;overexpression;Patch-Clamp Techniques;Patients;Pharmaceutical Preparations;Physiological;Potassium;Proliferating;Regulation;Reporting;Roentgen Rays;Site;Small Interfering RNA;small molecule;Small Molecule Chemical Library;Structure;Subcellular structure;Surface Plasmon Resonance;Techniques;Technology;Testing;Therapeutic;therapeutic evaluation;tissue culture;tumor;tumor growth;tumor progression;tumorigenesis;voltage/patch clamp;X-Ray Crystallography;Xenograft Model;Xenograft procedure;Zebrafish

PROJECT_TITLE: Functional mechanisms and therapeutic potential of EAG channel regulators


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE The successes of antiretroviral therapy in improving and extending life for people with HIV are significantly diminished by suboptimal adherence and adherence psychosocial and structural barriers. Forty percent of Latino men who have sex with men with HIV do not achieve viral suppression, largely due to suboptimal adherence. The proposed study seeks to evaluate the efficacy of stepped care strategies in improving antiretroviral therapy adherence among Latino men who have sex with men.

PI_NAMEs: SHEEHAN, DIANA MONTSERRAT (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Address;Adherence;Adult;Advocacy;antiretroviral therapy;Area;arm;Belief;care coordination;Caring;Case Management;CD4 Lymphocyte Count;Centers for Disease Control and Prevention (U.S.);Client;cost effectiveness;COVID-19 pandemic;Data;design;Disease Progression;Drug resistance;Ecological momentary assessment;efficacy evaluation;Epidemic;Evidence based intervention;Florida;forgetting;Foundations;Geography;Health;health disparity;health disparity populations;Health education;Health Insurance;Health Services Accessibility;high risk;HIV;HIV diagnosis;HIV disparities;Homelessness;improved;improved outcome;Individual;Informal Social Control;innovation;Interpersonal Relations;Intervention;Latino;Latino Population;Length of Stay;Life;men;men who have sex with men;Mental Health;mHealth;mhealth interventions;Outcome;pandemic stressor;patient navigation;patient navigator;Patients;Persons;pill;Population;post intervention;prevent;programs;psychosocial;Randomized;Randomized, Controlled Trials;Relationship-Building;Reporting;Risk;Sampling;Self Efficacy;Self Management;Sequential Multiple Assignment Randomized Trial;social cognitive theory;Social Work;Substance Use Disorder;success;Testing;Text;therapy adherence;Time;transmission process;treatment adherence;Treatment Protocols;trial design;Trust;two way texting;Unemployment;United States;United States National Institutes of Health;Viral;Viral Load result

PROJECT_TITLE: Efficacy of an mHealth + e-Navigator stepped care intervention for ART adherence among Latino MSM

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Eukaryotic histone proteins are fundamental to all biological processes and were historically thought to be highly conserved. However, histones proteins can be subject to evolutionary turnover in the form of gene duplications and dramatic sequence divergence in multiple eukaryotic lineages suggesting adaptive advantages. This proposal uses yeast and flies to investigate the fitness advantages of unique eukaryotic histone repertoires for two crucial functions – genome regulation and DNA damage response.

PI_NAMEs: RAMAN, PRAVRUTHA  (contact)

PROJECT_TERMS: Affect;Biological;Biological Assay;Biological Process;Biology;Birth;Cell Physiology;Cells;Chromatin;Defect;Development;Disease;DNA;DNA Damage;DNA Packaging;DNA Repair;DNA Repair Gene;Drosophila genome;Drosophila genus;Engineering;Eukaryota;Event;Evolution;Fertility;fitness;flexibility;fly;Foundations;Frequencies;fungus;Future;Gene Duplication;Gene Expression;Gene Expression Regulation;Gene Fusion;gene repression;Genes;Genetic;Genetic Transcription;Genome;genomic locus;Genomics;Growth;Heterochromatin;Histone Fold;Histone H2A;Histones;improved;in vivo;innovation;insight;Learning;Length;Link;Location;Malignant Neoplasms;Mediating;Meiosis;Mitosis;model organism;Molecular Evolution;mutant;Mutate;Mutation;N-terminal;novel;Organism;Partner in relationship;Phenotype;Phylogenetic Analysis;Play;pressure;prevent;Process;programs;Protein Family;Proteins;Recording of previous events;Recurrence;Regulation;Research;response;Role;Saccharomyces cerevisiae;Saccharomycetales;skills;Specificity;Tail;Testing;tool;Training;Variant;Work;Yeasts

PROJECT_TITLE: Functional consequences of evolutionary innovation in histone repertoires


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE.  Vibrio cholerae is a gram negative bacterium and facultative human pathogen that causes the acute diarrheal disease cholera. Cholera is an epidemic disease that is estimated to affect 3-5 million people each year. The research proposed in this project focuses on defining the mechanisms used by V. cholerae to cause human disease and survive in aquatic ecosystems. Defining these mechanisms will uncover novel targets for the development of new therapeutic approaches to treat cholera.

PI_NAMEs: BINA, JAMES EDWARD (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Acute Diarrhea;Address;Adherence;Affect;aquatic organism;bile salts;Cell Density;Cell division;Cells;Cholera;combat;Consumption;contaminated water;Cues;Dehydration;Development;Diarrhea;diarrheal disease;Disease;Down-Regulation;Drug Efflux;Ecosystem;environmental adaptation;Epidemic;Feedback;Food;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Gram-Negative Bacteria;Growth;Human;human disease;human pathogen;Impairment;In Vitro;in vivo Model;Infection;Ingestion;Intestines;Iron;Life Cycle Stages;Link;Mediating;Metabolism;Microbial Biofilms;Modeling;mutant;novel;novel strategies;novel therapeutic intervention;Paper;pathogen;Pathogenesis;periplasm;Persons;Phenotype;Process;Production;Proteins;purge;quorum sensing;Regulon;Repression;Research;Resistance;Resistance to infection;response;sensor;Signal Transduction;Signaling Molecule;Small Intestines;System;Testing;Toxin;transmission process;Up-Regulation;VAI-2;Vibrio cholerae;Virulence;Virulence Factors;virulence gene

PROJECT_TITLE: Environmental adaptation by Vibrio cholerae

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: RALEIGH

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: Project Narrative  This project investigates how fundamental metabolic processes (i.e., glycolysis and mitochondrial respiration) regulate the cellular events that drive the elongation and rotation of the embryonic digestive tract. The results will provide new insight into the etiology of intestinal malrotation, a common birth defect with significant morbidity. Moreover, as the morphogenetic mechanisms regulated by metabolism -- mesenchymal- to-epithelial transitions and interkinetic nuclear migration --underlie the proper formation of many tissues and organs throughout the embryo, the findings will also reveal how abnormal maternal or fetal metabolism could contribute to a wide variety of structural birth defects.

PI_NAMEs: NASCONE-YODER, NANETTE M (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Abnormal Cell;Affect;Animal Model;Animals;Architecture;Area;Atrazine;Behavior;Biological Assay;Birth;Cell division;Cells;Chloroplasts;Complex;Congenital Abnormality;Data;Defect;Development;Disease;Electron Transport;Embryo;epithelial to mesenchymal transition;Epithelium;Etiology;Event;Exposure to;fetal;Frequencies;Gastrointestinal tract structure;Generations;Genetic;Genus Hippocampus;Glycolysis;Glycolysis Pathway;Herbicides;Human;innovation;insight;Intestines;Length;Life;mass spectrometric imaging;Mass Spectrum Analysis;Mediating;Metabolic;Metabolism;metabolomics;Methodology;migration;Mitochondria;Modeling;Morbidity - disease rate;Morphogenesis;Nuclear;nutrition;Operative Surgical Procedures;Organ;Oxidative Phosphorylation;Pathogenesis;Patients;pharmacologic;Plants;Pregnancy;Process;Reaction;Respiration;Role;Rotation;spatiotemporal;Structural Congenital Anomalies;Surface;Technology;Testing;Therapeutic;Tissues;Toxic Environmental Substances;Toxin;transcriptome sequencing;Xenopus

PROJECT_TITLE: Metabolism and Malrotation

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: IRBID

ORG_COUNTRY: JORDAN

ORG_FIPS: JO

ORG_NAME: JORDAN UNIVERSITY/SCIENCE & TECHNOLOGY

PHR: Project Narrative The GeoHealth Hub Climate Change and Health in the Middle East and North Africa (MENA), a collaborative initiative between three U.S. universities and three universities from the MENA Region, to generate evidence for policies to minimize adverse health impacts of climate change in the region through state-of-the-art approaches. It will focus on climate-sensitive environmental risks such as nitrate pollution, heat waves, desert dust pollution, and air pollution. The overall activities of the hub aim to strengthen the capacity of different stakeholders on developing and using evidence-based and cost-effective interventions.

PI_NAMEs: ABDULLA, FAYEZ AHMAD (contact);AL-DELAIMY, WAEL K

PROGRAM_OFFICER_NAME: JESSUP, CHRISTINE

PROJECT_TERMS: Address;Africa;Age;Air Pollution;Allergic Disease;Area;Asia;Atmosphere;attributable risk;Birth Weight;burden of illness;California;Cardiovascular system;Centers for Disease Control and Prevention (U.S.);Child;Chronic Disease;Climate;climate change;climate impact;climate-related health;Communicable Diseases;cost;cost effective intervention;Cost-Benefit Analysis;Country;Data;Development;Droughts;Dust;dust storms;economic impact;Economics;Environment;Environmental Epidemiology;Environmental Health;Environmental Protection;Environmental Risk Factor;Epidemiologic Methods;Event;evidence base;follow-up;Frequencies;Gender;Geographic Locations;Goals;Harm Reduction;hazard;Health;Health Sciences;Heat Waves;Human;indexing;Intervention;Jordan;Latin America;Lebanon;Maps;maternal serum;Measures;member;Middle East;Modeling;Morbidity - disease rate;Morocco;mortality;National Institute of Environmental Health Sciences;Newborn Infant;Nitrates;Northern Africa;Outcome;Particulate;Particulate Matter;Pattern;Pilot Projects;Policies;policy recommendation;Pollution;Population;Precipitation;predictive modeling;Public Health;Public Health Schools;Public Policy;Research;Research Project Grants;respiratory;response;Risk;Risk Assessment;Sampling;Science;Seasons;Skin;Techniques;Technology;tool;Training;Universities;Vulnerable Populations;Water;Water Pollution;water quality;water quality model;weather patterns;Woman;World Health Organization

PROJECT_TITLE: 1/2 GeoHealth Hub for Climate Change and Health in the Middle East and North Africa-Jordan

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Q(70)R]


ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research aims to determine the cell identity, electrophysiological properties, and functional connectivity of hippocampal long-range projecting GABAergic neurons, and examine whether this long-range inhibition coordinates and synchronizes activity between the hippocampus and subcortical regions in memory formation. Given that impairments of coordination and synchronization between the hippocampus and other brain areas have been implicated in a number of neurological and psychiatric disorders, such as Alzheimer’s disease and depression, the knowledge gained from this proposal will provide new insights into both normal functions of hippocampal-subcortical circuits and their potential involvement in diseases.

PI_NAMEs: SUN, QIAN  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Anatomy;Area;Ataxia;Axon;Behavior;Behavioral;Brain;Brain Diseases;Brain region;Cell Nucleus;cell type;Cells;cholinergic neuron;Dependovirus;Diagonal Band of Broca;Disease;Distant;electrical property;Electrophysiology (science);experimental study;FLP recombinase;Frequencies;Future;Glutamates;hippocampal pyramidal neuron;Hippocampus;Hypothalamic structure;Immunohistochemistry;in vivo;inhibitory neuron;Injections;insight;Interneurons;Knowledge;knowledge base;Label;Learning;Literature;Major Depressive Disorder;Medial;Memory;memory encoding;memory retrieval;Mental Depression;Mental disorders;Mus;Nervous System Disorder;neural;neurochemistry;Neurons;optogenetics;Pacemakers;patch clamp;Pathway interactions;Periodicity;Physiological;Population;Population Dynamics;Positioning Attribute;postsynaptic;Property;Research;Role;Schizophrenia;Slice;Somatostatin;spatial memory;Subgroup;Synapses;Testing;Viral;way finding;Whole-Cell Recordings

PROJECT_TITLE: Long-range GABAergic inhibition coordinates hippocampal-subcortical circuit activity in memory formation

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Diseases of the retina affect approximately three million Americans, about 1 million of whom are blind. In many of these conditions, including age-related macular degeneration (AMD), diabetic retinopathy and retinitis pigmentosa, blindness is caused by the loss of rod and cone photoreceptor cells. Therefore, the prospect of therapeutic treatments for a wide array of these conditions depends on scientific advances in our understanding of the biochemistry, physiology, cell biology, molecular biology and genetics of photoreceptor function. Of critical importance in accomplishing this goal is the open exchange of new research findings among the community of vision scientists and the cultivation of the next generation of researchers to study photoreceptor biology and pathobiology. The FASEB Science Research Conference on “The Biology and Chemistry of Vision” is the premier meeting in the field of photoreceptors and their supporting cells. This biennial conference attracts the leading investigators in the field and is well-attended by young investigators, postdoctoral fellows, and students. It represents unique opportunities to propel new developments in vision research, articulate pressing questions and foster new collaborations.

PI_NAMEs: ROBINSON, PHYLLIS R;SAMPATH, ALAPAKKAM P (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Address;Affect;Age related macular degeneration;American;Area;Articulation;Biochemistry;Biological;Biology;blind;Blindness;career development;Cells;Cellular biology;Chemistry;Collaborations;Communities;Data;Defect;design;Development;Diabetic Retinopathy;Discipline;Disease;Education;educational atmosphere;Educational workshop;Epithelium;Fees;Fostering;Friends;Funding;Future;Goals;graduate student;Grant;GTP-Binding Proteins;Influentials;insight;interdisciplinary approach;interest;Knowledge;lectures;Macular degeneration;meetings;Membrane Potentials;Metabolism;Molecular Biology;Molecular Genetics;multidisciplinary;Nature;neural circuit;neurophysiology;next generation;novel;Participant;Photons;photoreceptor degeneration;Photoreceptors;Physiological;Physiology;Population;Postdoctoral Fellow;posters;pre-doctoral;Productivity;professor;programs;protein function;protein structure;Published Comment;Publishing;Reporting;Request for Proposals;Research;Research Personnel;Retina;Retinal Diseases;Retinal Photoreceptors;Retinitis Pigmentosa;Role;Schedule;Science;Scientific Advances and Accomplishments;Scientist;Selection Criteria;Signaling Protein;Societies;structural biology;Structure;Structure of retinal pigment epithelium;Students;Supporting Cell;symposium;Techniques;Therapeutic;Time;Travel;trend;Underrepresented Populations;United States National Institutes of Health;Vertebrate Photoreceptors;Vision;Vision research;Visual;Work;Writing

PROJECT_TITLE: FASEB's The Biology and Chemistry of Vision Conference


ADMINISTERING_IC: NS

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Nerve pain caused by nerve injury and neuropathy remains a major clinical problem and a therapeutic challenge. In this proposal, we plan to investigate the epigenetic mechanism involved in the development of chronic nerve pain. Findings from this proposal will provide new insight into the molecular mechanisms of nerve pain and will help the development of new therapies for treating chronic nerve pain.

PI_NAMEs: CHEN, SHAO-RUI ;PAN, HUI-LIN  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Ablation;Acetylation;Address;Afferent Neurons;Analgesics;antinociception;Behavioral;Binding;casein kinase II;chemotherapy;chromatin modification;Chromatin Structure;Chronic;chronic pain;Clinical;CNR1 gene;Data;Development;Dissociation;DNA Methylation;dorsal horn;Down-Regulation;Epigenetic Process;epigenetic silencing;G9a histone methyltransferase;Gene Expression;Gene Targeting;Genes;Genetic;Genetic Transcription;genome-wide;Goals;HDAC2 gene;Histone Acetylation;Histone Deacetylase;Histones;Hypersensitivity;Individual;injured;innovation;insight;knock-down;Knock-out;Knowledge;Lysine;Malignant Neoplasms;Mediating;Molecular;Mus;N-Methyl-D-Aspartate Receptors;nerve injury;Nerve Pain;Neuronal Plasticity;Neurons;Neuropathy;NMDA receptor antagonist;Nociception;novel therapeutics;Opioid;Paclitaxel;Pain;pain chronification;pain model;painful neuropathy;Peripheral Nerves;Pharmaceutical Preparations;Phenotype;Phosphorylation;Play;Posterior Horn Cells;Potassium Channel;promoter;Protein Inhibition;Receptor Activation;Receptor Gene;Regulation;Repression;restraint;Role;Small Interfering RNA;Spinal;Spinal Cord;Spinal Ganglia;Surgical Injuries;Synapses;Synaptic plasticity;Tail;Testing;Therapeutic;Therapeutic Effect;transcriptomics;Transgenic Mice;Traumatic injury;Traumatic Nerve Injury;Up-Regulation

PROJECT_TITLE: Mechanisms of Epigenetic Plasticity in Neuropathic Pain

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Social positions within workplaces have been shown to be associated with increased morbidity and shorter life expectancy, but the causality and mechanisms behind this association remain unclear. Our proposed study will use administrative health and earnings records from millions of workers in Utah to examine the causal pathways between workplace social status and minority health disparities in a broad and diverse US population. We will extend the literature to examine the mechanisms behind persistent health disparities that operate intergenerationally or through social networks with coworkers, quantify how these channels contribute to structural racial and ethnic health disparities, and estimate how public policies might mitigate these health disparities.

PI_NAMEs: LAVETTI, KURT  (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Adult;Adult Children;Age;American Indians;Area;career;Child;Code;Data;Databases;Death Records;design;Diagnosis;disparities in morbidity;Economics;Employment;Enrollment;ethnic disparity;ethnic health disparity;ethnic minority;Ethnic Origin;Etiology;Evolution;Gender;gender disparity;Generations;Geography;hazard;Health;health care disparity;health care service utilization;health determinants;health difference;health disparity;Health Insurance;Health Status;Healthcare;Hospitalization;Household;Industry;Inequality;instrument;intergenerational;International;Life Expectancy;Link;Literature;Marketing;Measures;Medical;Methodology;Minority;minority health disparity;Morbidity - disease rate;mortality;Names;novel;Occupations;Outcome;Parents;Pathway interactions;Pattern;Persons;Play;Population;psychosocial;Psychosocial Factor;Public Policy;Quasi-experiment;Race;racial disparity;racial health disparity;racial minority;racial population;Records;Reduce health disparities;Research;Research Design;residence;Resources;Risk;Role;segregation;Shock;social health determinants;Social Network;Social status;Socioeconomic Status;socioeconomics;statistics;Structure;Techniques;Testing;Time;tribal Nation;US State;Utah;Variant;Work;Workplace

PROJECT_TITLE: The Effects of Workplace Social Status on Minority Health Disparities

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: NARRATIVE Time of flight positron emission tomography (TOF-PET) is a very effective nuclear medicine technique to diagnose cancer, cardiovascular diseases, and musculoskeletal disorders. Novel modalities of TOF-PET have emerged during the last years, such as long axial field of view (LA- FOV) TOF-PET or studies with very low dose uptake, but state-of-the-art detectors used in TOF- PET are hindering their progression due to the elevated production cost and intrinsic physical properties. In this project, we will evaluate the feasibility of using a new detector material, thallium chloride, as it offers a low production cost and very attractive physical properties that can allow for a practical adoption and spread of the most recent TOF-PET techniques.

PI_NAMEs: ARIÑO ESTRADA, GERARD  (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TITLE: TOF-PET with high-efficiency TlCl crystals

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: MERCED

ORG_NAME: UNIVERSITY OF CALIFORNIA, MERCED

PHR: U*RISE at UC Merced - Project Narrative The focus of our U*RISE proposal is to provide robust and enhanced research experiences with supplemental training in computational biology and/or systems biology including bioinformatics, multiple “-omics” approaches, and big data analytics. We propose to take a cohort, peer- mentoring approach that allows the scholars an opportunity to provide direct, hands-on peer- mentoring in conjunction with the faculty’s mentoring and supervision, and also integrate a highly innovative modular-learning approach to the training of scholars. Given UC Merced’s status as a Hispanic Serving Institution and the number of highly qualified undergraduates in Biology, Chemistry, and Math, recruiting and retaining these scholars will be easily achieved, and our history of successful training program implementation and achievements make UC Merced ideally situated to successfully implement the proposed U*RISE at UC Merced program.

PI_NAMEs: NISHIGUCHI, MICHELE KIYOKO;ORTIZ, RUDY M (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Big Data Methods;biobehavior;Bioinformatics;California;cohort;Computational Biology;Data;demographics;Discipline;Disparity;Enrollment;Ensure;Extramural Activities;Faculty;Funding;Grant;health science research;Hispanic;Hispanic ancestry;Hispanic-serving Institution;innovation;Institution;Learning Module;Mathematics;multiple omics;novel;programs;Recording of previous events;Research Institute;Research Training;Resources;skills;statistics;Students;success;Systems Biology;Training;undergraduate education;undergraduate research experience;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: U-RISE at UC Merced

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]