ORG_CITY: WASHINGTON

ORG_NAME: NATIONAL FARMERS UNION FOUNDATION

ORG_STATE: DC

PHR: U.S. Food and Drug Administration (FDA) Center for Food Safety and Applied Nutrition (CFSAN) RFA-FD-23-031: Renewal - Local Food Producer Outreach, Education, and Training to Enhance Food Safety and FDA Food Safety Modernization Act (FSMA) Compliance (U01) Local Food Safety Collaborative | National Farmers Union Foundation July 11, 2023 Project Narrative This project is dedicated to helping local food producer audiences who have a unique place within Food Safety Modernization Act (FSMA) regulations. Local food producers experience challenges as they attempt to understand and satisfy food safety requirements. The Local Food Safety Collaborative (LFSC), remains dedicated to helping local farmers and processors advance their food safety knowledge and capacity to increase compliance, enhance the economic viability of their operations, and enable them to continue providing consumers with safe, healthy local food.

PI_NAMEs: MCCARTHY, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: ALLEN, MARION

PROJECT_TITLE: Local Food Safety Collaborative


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Clinical Research;Complementary and Integrative Health;Dietary Supplements;Microbiome;Nutrition;Obesity;Osteoarthritis

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ORTHOPEDICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE This project aims to 1) definitively establish that a pro-inflammatory dysbiotic gut microbiome is causal in the OA of obesity, and 2) demonstrate that correction of this dysbiosis using strategies to expand B. pseudolongum will decelerate the progression of OA in the obese context.

PI_NAMEs: GILL, STEVEN R.;ZUSCIK, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Ablation;Acceleration;Actinobacteria class;Address;Arthritis;B-Lymphocytes;Bifidobacterium;Blood;Cells;Circulation;Colon;Communication;Communities;comorbidity;cytokine;Data;Deceleration;Degenerative polyarthritis;Development;diet-induced obesity;Dietary Supplementation;Disease;dysbiosis;Epithelium;Experimental Designs;experimental study;Family member;Fiber;gut dysbiosis;gut microbiome;Health;High Fat Diet;Human;Immune;Inflammation;Inflammatory;Intestines;joint destruction;joint loading;Joints;Knee;Knee joint;Link;Macrophage;Mechanics;Medial meniscus structure;Messenger RNA;Metabolic;Metabolism;metabolome;metagenome;metatranscriptome;Methods;microbial;microbiome composition;microbiota;Modeling;mouse model;Movement;multiple omics;multiplex assay;Mus;nano-string;novel therapeutic intervention;Obese Mice;Obesity;Operative Surgical Procedures;Oral;Organoids;palliative;Pathogenicity;Peptococcaceae;prebiotics;Probiotics;Process;resident commensals;Role;Serum;Supplementation;Synovial Membrane;systemic inflammatory response;Taxonomy;Testing;Thinness;Time;Tissue Harvesting;Tissues;transcriptomics;Transgenic Mice;Transplantation;Up-Regulation;Work

PROJECT_TITLE: Studies on gut microbiome-joint connections in arthritis

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Aging;Complementary and Integrative Health;Data Science;Genetics;Human Genome

ORG_CITY: ROUND ROCK

ORG_NAME: DELL FEDERAL SYSTEMS L.P.

ORG_STATE: TX

PI_NAMEs: HAMMONDODWYER, AMY K (contact);SIDDIQUI, ERUM

PROGRAM_OFFICER_NAME: WEBER, MICHAEL NICHOLAS N

PROJECT_TERMS: Acceleration;Address;Biomedical Research;Cloud Computing;Cloud Service;cloud storage;Communities;computerized tools;Data;Data Commons;data ecosystem;data repository;Data Science;Data Set;Economics;FAIR principles;Funding;Goals;Image;Individual;large datasets;Modeling;Modernization;Phase;Policies;Procedures;Process;programs;Research Infrastructure;Research Personnel;Science;Series;service providers;Services;Strategic Planning;Technology;Testing;Training;United States National Institutes of Health;Work

PROJECT_TITLE: NIH STRIDES - Azure and Associated Services and Training.

SUFFIX: SA


ADMINISTERING_IC: HG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: GAINESVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE This research will develop the means to build a pangenomic reference genome, which will be applied in order to construct a novel human reference genome that encapsulates variation within the population. This will, in turn, facilitate the study of complex traits and diseases that require the use of a multifactorial, high-quality reference genome. Examples of such diseases and traits include cancer sub-types, autism, schizophrenia, and Parkinson’s disease.

PI_NAMEs: BOUCHER, CHRISTINA  (contact);LANGMEAD, BENJAMIN THOMAS

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TERMS: Achievement;Address;Adopted;Algorithms;Area;autism spectrum disorder;Bioinformatics;Biology;cancer subtypes;Collaborations;Collection;Complex;Computer software;cost;Data;data structure;Development;Disease;effectiveness evaluation;Encapsulated;Ensure;Feedback;Genetic study;genetic variant;Genetic Variation;Genome;Goals;Human Genome;human reference genome;improved;indexing;interest;Licensing;Maintenance;Methods;Monitor;novel;open source;pan-genome;Parkinson Disease;Performance;Population;prevent;public database;reference genome;Reference Standards;Research;Research Personnel;Scheme;Schizophrenia;Scoring Method;Sequence Alignment;Statistical Models;Structure;telomere;Time;trait;Update;usability;user-friendly;Variant;variant detection;Work

PROJECT_TITLE: Fully Realizing Pangenomics Alignment


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PI_NAMEs: ALLEN, MICHELE L (contact);HARDEMAN, RACHEL R;PATTEN, CHRISTI A

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TITLE: Understanding facilitators and barriers for the utilization of an Indigenized meal kit amongst urban Minnesota Native American youth and families


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative Statement We propose continuation of M-CERSI that fosters FDA-oriented research, as well as regulatory science information sharing opportunities. The Center's mission is to foster the development of regulatory science – the science of developing new tools, standards and approaches to assess the safety, efficacy, quality and performance of FDA-regulated products. Activities leverage the close geographic proximity between University of Maryland and FDA's main campus.

PI_NAMEs: BENTLEY, WILLIAM E.;POLLI, JAMES E (contact)

PROGRAM_OFFICER_NAME: SEPULVEDA, KRISTIN

PROJECT_TITLE: University of Maryland Center of Excellence in Regulatory Science and Innovation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: AMHERST

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative This study seeks to use novel methods and data to address the following aims: 1) Examine the relationship between regional exposure to structural racism and the propensity of hospital and clinic closures; 2) examine the relationship between hospital and clinic closures and community assets (pertaining to employment, income, and education) and community health outcomes (across mortality, disability, and chronic disease burden); 3) predict risk of closure among urban hospitals and clinics that are disproportionately serving racial/ethnic minorities from neighborhoods with exposure to structural racism (defined as historic redlining); 4) undertake stakeholder engagement to address prevention of future closures and/or examine ways to decrease the potential adverse community impact of hospital and clinic closures.

PI_NAMEs: EGEDE, LEONARD E. (contact);LINDE, SEBASTIAN

PROJECT_TERMS: Acute;Address;Affect;Area;Attention;burden of chronic illness;Caring;Clinic;Clinics and Hospitals;Code;Communities;Community Health;COVID-19 pandemic;Crows;Data;Diabetes Mellitus;differences in access;disability;Discrimination;disparity gap;econometrics;Economics;Education;Employment;ethnic health disparity;ethnic minority;ethnic minority population;Ethnic Origin;Event;explainable machine learning;Exposure to;Fostering;Future;gaps in access;Goals;Health;health care availability;health disparity;Hospital Closures;Hospitals;Housing;Income;Individual;Inequity;inner city;innovation;Insurance;intergenerational;Investments;Knowledge;Laws;Legal;Link;Literature;machine learning method;Measures;Methodology;Methods;mortality;Myocardial;Neighborhoods;novel;Outcome;Pathway interactions;Policies;poor health outcome;Prevention;Primary Care;Quality of Care;Race;racial health disparity;racial minority;racial minority population;Resources;Risk;Risk Factors;risk prediction;Rural;Rural Hospitals;Schools;segregation;Services;Shock;social;Societies;Structural Racism;System;trend;United States Agency for Healthcare Research and Quality;Urban Community;Urban Hospitals;urban setting;Work

PROJECT_TITLE: Impact of structural racism on hospital/clinic closures, community assets, and health outcomes in urban communities

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SEATTLE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE This research seeks to develop models for predicting how genetic variation affects mRNA stability and translation efficiency. To train these models, we will collect data from massively parallel reporter assays in multiple cell lines targeting the UTR and CDS mRNA regions. We will also develop a new technology for characterizing protein expression levels using high-throughput nanopore sequencing of barcoded protein reporters, which will allow us to improve the sensitivity and accuracy of our protein measurements by surpassing the limitations of current methods such as ribosome loading.

PI_NAMEs: NIVALA, JEFFREY MATTHEW (contact);SEELIG, GEORG

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;Address;Affect;Amino Acid Sequence;Bar Codes;Behavior;Biological;Biological Assay;Catalogs;Cell Line;cell type;ClinVar;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complement;Conserved Sequence;CRISPR interference;Data;Data Set;Databases;de novo mutation;deep learning;deep learning model;design;Development;disease phenotype;experimental study;falls;Gene Expression;gene function;Genes;Genetic Transcription;genetic variant;Genetic Variation;genome sequencing;genome wide association study;Goals;Human;Human Genome;improved;insight;Investigation;knock-down;Learning;Length;Libraries;Link;Location;Machine Learning;Measurement;Measures;Messenger RNA;Methods;Modeling;Molecular;molecular phenotype;mRNA Stability;mRNA Translation;nanopore;new technology;novel;novel strategies;Pathogenicity;Peptide Sequence Determination;Phenotype;Polyadenylation;polysome profiling;Positioning Attribute;predictive modeling;pressure;Process;Production;protein expression;Proteins;Proxy;rare variant;recurrent neural network;Regulation;Regulatory Element;Reporter;Research;Resolution;ribosome profiling;Ribosomes;RNA Splicing;RNA-Binding Proteins;screening;sensor;sequence learning;Signal Transduction;Specificity;Statistical Methods;Stratification;synthetic biology;Technology;Testing;Tissues;Training;training data;Transcript;transcriptome;translational model;Translations;Untranslated Regions;Untranslated RNA;Variant;variant detection;Work

PROJECT_TITLE: Integrating the impacts of genetic variation with massively parallel mRNA and protein barcoding

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homicide and Legal Interventions;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence;Youth Violence Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

PHR: This cooperative agreement project entails formative research to finalize intervention elements and data collection protocols, followed by the implementation and evaluation of a unique community-level intervention to prevent firearm violence among youth in a Washington, DC community.

PI_NAMEs: EDBERG, MARK  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Academic support;Address;Affect;African American;Age;Area;Attitude;authority;Baseline Surveys;Behavior;Behavioral;Cause of Death;Cities;cohort;Collaborations;Collection;Communication;Communities;community center;community collaboration;Community Health;community intervention;community organizations;community partners;Data;Data Analyses;Data Collection;data sharing;design;Development;District of Columbia;Elements;Ethnic Population;Evaluation;expectation;Female;Firearms;follow-up;Gender;Genus Mentha;gun violence;health disparity;Health Service Area;Homicide;Housing;Information Dissemination;instrument;Intervention;intervention effect;journal article;Lawyers;Life;Life Cycle Stages;Link;male;Manuals;marginalization;Mediator;meetings;Mentors;metropolitan;minority children;Outcome;Parents;Pathway interactions;Pattern;Persons;Phase;pilot test;Police;positive youth development;Poverty;prevent;Prevention;preventive intervention;Process;programs;Protocols documentation;Public Health;Public Health Schools;Quasi-experiment;racial population;racism;recruit;Research;Sampling;Shotguns;social media;social norm;socioeconomics;study population;Surveys;theories;Time;Training;U-Series Cooperative Agreements;Universities;Violence;violence prevention;violent crime;Washington;web site;Youth

PROJECT_TITLE: Changing the Narrative on Firearms Violence: A Community Collaborative Intervention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CCHI-B(50)]


PHR: Project Narrative This study will use novel methods and extensive data sources to: 1) Examine the relationship between regional exposure to structural racism (defined as: historic redlining) and present-day social risk factors, human capital, and health care resources; 2) examine the direct and indirect effects of regional exposure to structural racism on health outcomes via social risk, human capital, and healthcare resources; 3) assess policy levers of federal, state, and local governments that can be used to reduce area vulnerabilities to historic structural racism, and that can reduce present-day racial/ethnic disparity gaps in health outcomes; and 4) Engage a diverse set of key stakeholders to identify and prioritize strategies for mitigating social risk, building human capital, and improving health care resources and outcomes for regions exposed to structural racism through historical redlining.

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TITLE: Structural Racism and Disparities in Social Risk, Human Capital, Health Care Resources, and Health Outcomes: A Multi-level Analysis of Pathways and Policy Levers for Change


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease;Prevention;Substance Misuse

ORG_CITY: SHREVEPORT

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PI_NAMEs: BHUIYAN, MOHAMMAD ALFRAD NOBEL  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: 8-hydroxy-2'-deoxyguanosine;Applications Grants;Biological Markers;Biology;biomarker identification;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;central database;Clinical Data;clinically significant;Data;data repository;Disease;Environmental Exposure;epidemiologic data;Equilibrium;Individual;Information Management;Intervention;Link;Measures;metabolomics;novel strategies;Oxidation-Reduction;oxidative damage;Oxidative Stress;Oxidative Stress Induction;Participant;Patients;Plasma;potential biomarker;Proteins;Public Health;Research;Sampling;Science;substance use;Substance Use Disorder;therapeutic target;United States National Center for Health Statistics;volatile organic compound;Work

PROJECT_TITLE: Redox, Environmental, and Metabolomics: investigating Disease Yield (REMEDY)


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Pediatric

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE – Overall. People with Down syndrome are strongly predisposed to develop a wide range of comorbidities that shorten their lifespan and decrease their quality of life, such as Alzheimer’s disease, congenital heart disease, leukemias, autoimmune disorders, and diverse neurological conditions. The proposed activities under this project seek to create a world-class resource for collaborative discovery, data sharing, data access, and integrative analysis that would enable novel investigations into all DS comorbidities across the lifespan and further integrating across datasets for related diseases occurring in the general population, thus paving the way for a precision medicine approach to DS. Furthermore, this resource and associated platforms will also have broader impacts by empowering physicians, educators, government officials, and advocates with the tools required to elicit evidence- based transformative action in the clinic, the classroom, the government, and society at large.

PI_NAMEs: CARROLL, ROBERT J;DIGIOVANNA, JACK ;ESPINOSA, JOAQUIN M.;FERRETTI, VINCENT ;HAENDEL, MELISSA A;RESNICK, ADAM CAIN (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Acceleration;Advocacy;Advocate;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid Beta A4 Precursor Protein;Area;autism spectrum disorder;Autoimmune Diseases;Automobile Driving;bench to bedside;biobank;Biomedical Research;Child;Chromosome 21;Chromosomes;Clinic;Clinical;Cohort Studies;Collaborations;Communities;community empowerment;comorbidity;Complex;congenital heart abnormality;Data;data access;Data Coordinating Center;data ecosystem;data hub;data integration;data management;data modalities;data portal;data resource;Data Set;data sharing;data sharing networks;design;Development;Discipline;Disease;diverse data;Down's Syndrome;Ecosystem;Education;empowerment;Ensure;Environmental Risk Factor;epidemiology study;Epigenetic Process;Epilepsy;evidence base;Family;General Population;Genetic Diseases;Genetic Variation;Goals;Government;Government Officials;Human;Human Biology;Image;Individual;Infrastructure;innovation;interoperability;Intuition;Investigation;leukemia;Life Cycle Stages;Life Expectancy;life span;lifestyle factors;Link;Malignant Neoplasms;metabolome;Methods;microbiome;Mission;Multiomic Data;Neurologic;novel;novel diagnostics;novel therapeutics;outreach;Participant;Pathogenicity;Persons;Phenotype;Physicians;Population;precision medicine;prenatal;Proteome;Quality of life;Research;Resources;Risk;Schools;Scientist;Societies;Solid;Surveys;synergism;Technology;Time;timeline;tool;Training;transcriptome;United States National Institutes of Health;Variant;virtual

PROJECT_TITLE: Integrating Imaging-based Infrastructure into the INCLUDE Data Hub


NIH_SPENDING_CATS: Back Pain;Bioengineering;Chronic Pain;Pain Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Discogenic back pain, is a leading cause of disability, and involves degenerative changes of the intervertebral disc. Only a small subset of patients responds favorably to existing treatments, and there is a need for alternative options, including regenerative therapies. We are developing and optimizing use of anti-inflammatory cells for disc repair in hope that it improves outcomes for patients with back pain and degeneration.

PI_NAMEs: CHAHINE, NADEEN O. (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Address;Animal Model;Animals;Anti-Inflammatory Agents;Architecture;Area;Back Pain;Biochemistry;Biological;Biomechanics;bone marrow mesenchymal stem cell;Cell Transplantation;Cells;clinical efficacy;Clinical Research;Coculture Techniques;combat;Consensus;conventional therapy;Custom;cytokine;Data;disability;discogenic pain;Disease;Economic Burden;enhancing factor;Environment;Extracellular Matrix;Extracellular Matrix Degradation;Frequencies;Future;Goals;Height;Human;Hydrostatic Pressure;Immobilization;immunoregulation;improved;improved outcome;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;injured;Injury;innovation;Intervertebral disc structure;intervertebral disk degeneration;Label;Low Back Pain;Macrophage;mechanical load;Mediating;Mesenchymal Stem Cell Transplantation;Mesenchymal Stem Cells;Methods;migration;Modeling;Motion;Nitric Oxide;Operative Surgical Procedures;Opiate Addiction;Organ Culture Techniques;Outcome;pain behavior;Pain management;pain outcome;Paracrine Communication;patient subsets;Patient-Focused Outcomes;Physical therapy;Physiological;pre-clinical;Pre-Clinical Model;Production;Puncture procedure;Rattus;regenerative therapy;repaired;Research;response;Role;Severities;Signal Transduction;socioeconomics;Stem cell transplant;stem cells;Stimulus;Structural defect;Symptoms;System;Therapeutic;Tissues;TNF gene;Transforming Growth Factor beta;Transplantation;Treatment Efficacy;Up-Regulation

PROJECT_TITLE: Anti-inflammatory Cell Based Repair of Intervertebral Disc Degeneration

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Coronaviruses;Coronaviruses Diagnostics and Prognostics;Data Science;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: NATIONAL CANCER INSTITUTE

PROJECT_TERMS: 2019-nCoV;Address;Award;Cellular Phone;Common Data Element;Communities;Computer Analysis;Computerized Medical Record;computerized tools;conditioning;Contracts;COVID-19;COVID-19 pandemic;Data;Data Analyses;data de-identification;Data Discovery;data hub;data integration;data management;data modeling;data pipeline;data repository;Data Set;Deposition;Development;digital health;digital repositories;future pandemic;Goals;Institution;insurance claims;Laboratories;Learning;Link;machine learning model;Modeling;multiple data sources;National Cancer Institute;National Institute of Biomedical Imaging and Bioengineering;pandemic disease;population health;predictive modeling;privacy preservation;programs;quality assurance;Quality Control;RADx;Research;Research Personnel;response;Source;Standardization;Surveys;Technology;tool;United States National Institutes of Health;Virus;wearable sensor technology

PROJECT_TITLE: CSSI MIT/LL Digital Health Solutions (DHS) for COVID-19


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Substance Misuse

ORG_CITY: RESTON

ORG_NAME: CARAHSOFT TECHNOLOGY CORPORATION

ORG_STATE: VA

PI_NAMEs: DRINKWINE, TERRY  (contact)

PROJECT_TERMS: Acceleration;Address;Biomedical Research;Cloud Computing;Cloud Service;cloud storage;Communities;computerized tools;Data;Data Commons;data ecosystem;data repository;Data Science;Data Set;Economics;FAIR principles;Funding;Goals;Image;Individual;large datasets;Modeling;Modernization;Phase;Policies;Procedures;Process;programs;Research Infrastructure;Research Personnel;Science;Series;service providers;Services;Strategic Planning;Technology;Testing;United States National Institutes of Health;Work

PROJECT_TITLE: STRIDES


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

PHR: PROJECT NARRATIVE Dysregulation of inhibitory synapses, specifically GABAARs, alters excitatory-inhibitory balance and has been implicated in a number of neurological disorders, including ischemia. GABAAR trafficking regulates overall inhibitory synaptic strength and is influenced by phosphorylation status of the receptor. Here, I propose to test the hypothesis that GABAAR trafficking during OGD is differentially regulated based on neuronal populations, and this contributes to defined synaptic and cellular alterations based on the susceptibility of these neuronal populations.

PI_NAMEs: GARCIA, JOSHUA DAYLON (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TITLE: The role of dendritic excitability in controlling GABAergic synapse maturation


ACTIVITY: ZIA

ADMINISTERING_IC: AI

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Arthritis;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Zika Virus

PI_NAMEs: PIERSON, THEODORE  (contact)

PROJECT_TERMS: Acceleration;Adult;Antibodies;Antibody Repertoire;Antibody Response;Arboviruses;Area;Arthralgia;Arthritis;Binding;Biology;Breathing;Characteristics;Complex;Conjunctivitis;Country;Coupled;Culicidae;Data;Defect;Degree requirements;Development;diagnostic strategy;diagnostic value;Disease;Disease Outbreaks;env Gene Products;Epidemic;Epitopes;Evaluation;Exanthema;Fever;Flavivirus;Flavivirus Infections;Goals;Guillain Barré Syndrome;human disease;Humoral Immunities;Immune;Immune Sera;immunogenicity;in vivo;Infant;Infection;insight;Intervention;Island;Laboratories;Lead;Learning;Microcephaly;Micronesia;Molecular Conformation;Monoclonal Antibodies;National Institute of Allergy and Infectious Disease;Neurologic;neutralizing antibody;novel diagnostics;Pacific Islands;Pathogenesis;polyclonal antibody;Population;pregnant;Public Health;rational design;Reporting;Research;Resolution;response;RNA Viruses;Sampling;Source;South America;Structural Models;Structure;Surface;System;tool;translational impact;transmission process;United States;Vaccination;vaccine development;Vaccines;Viral;Viral Antigens;Viral Envelope Proteins;viral transmission;Virion;Virus;Virus Diseases;Woman;Work;Zika Virus;Zika virus vaccine;ZIKV infection

PROJECT_TITLE: The humoral response to Zika virus infection and vaccination


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PROJECT_TERMS: adverse pregnancy outcome;Africa;Antibodies;Arboviruses;Biology;Bunyamwera virus;Canada;Caribbean region;Central America;Childhood;Dengue;Development;Disease;Disease Outbreaks;Fever;Human;Immune response;Immunity;Immunization;Infection;La Crosse virus;Monoclonal Antibodies;mouse model;Nervous System Disorder;Oropouche virus;Orthobunyavirus;Prevention;programs;Research;South America;Therapeutic;Vaccination;Vaccine Antigen;Vaccine Design;Vaccines;Viral Hemorrhagic Fevers;Virus;Virus Diseases;Work

PROJECT_TITLE: Bunyavirus biology, immunity, and countermeasure development


ADMINISTERING_IC: CL

IC_NAME: CLINICAL CENTER

ORG_NAME: CLINICAL CENTER

PI_NAMEs: CHAN, LEIGHTON  (contact)

PROJECT_TERMS: Activities of Daily Living;Address;adjudication;Agreement;Algorithms;analytical tool;Area;Articulation;Assessment tool;beneficiary;Boston;career development;Characteristics;Classification;Clinical;Cognition;Collaborations;collected works;Communication;Communities;comparative;Computer software;Computerized Medical Record;Computers;Data;Decision Making;Development;Device or Instrument Development;Diagnosis;diagnostic tool;disability;Disability Evaluation;disability payment;Disabled Persons;Documentation;Emotions;Ensure;Equity;functional disability;Health;Health Personnel;Impairment;Individual;Informal Social Control;innovation;instrument;International;Interpersonal Relations;Language;Life;Longitudinal Studies;Machine Learning;Measures;Medical;Medical Electronics;Medical Records;Mental Health;mental representation;Methods;Modeling;Moods;Motor;Natural Language Processing;new technology;novel;Occupations;Patient Self-Report;Persons;Physical Function;Pilot Projects;pressure;Process;programs;Records;Regulation;Reporting;Research;Research Project Grants;research study;resilience;Respondent;response;safety net;Sampling;Science;Security;Self Assessment;Self Care;Social Functioning;Source;Statutes and Laws;Strategic Planning;Structure;Supported Employment;System;Technology;Testing;Text;theories;Time;timeline;Translating;United States National Institutes of Health;United States Social Security Administration;Universities;Update;Validity and Reliability;Work;Workplace

PROJECT_TITLE: Analyzing the SSA Disability Evaluation Process


PROJECT_TERMS: Aerobic;Aerobic Exercise;Algorithms;American;arm;Behavioral;Cardiac Output;Cardiology;cardiorespiratory fitness;Cell Respiration;Chronic Obstructive Pulmonary Disease;Chronic pulmonary heart disease;Clinical Research;Clinical Trials;college;Congestive Heart Failure;Consensus;Data;Data Analyses;Disease Management;Drops;Education;Effectiveness;Energy Metabolism;Enrollment;evidence based guidelines;Exercise;exercise intensity;exercise rehabilitation;Exercise Test;exercise training;exhaustion;Fatigue;follow-up;Gases;health related quality of life;improved;indexing;International;Interstitial Lung Diseases;Level of Evidence;Lung;Manuscripts;Measurement;Measures;Medical;Metabolic;Modality;Moods;Muscle;open data;Outcome;Oxygen;Oxygen Consumption;Participant;Patient Education;Patient Self-Report;Patients;Performance;Phase II Clinical Trials;Physical activity;Physical Performance;Physicians;Physiological;Preparation;Protocols documentation;psychosocial;Publishing;Pulmonary Hypertension;pulmonary rehabilitation;Qualifying;Quality of life;Questionnaires;Randomized;randomized trial;Readiness;Recommendation;recruit;Regimen;Rehabilitation therapy;Reporting;Research;response;Rest;Safety;Sample Size;screening;sedentary;Severities;Strenuous Exercise;symposium;Symptoms;Test Result;Testing;Time;Training;Training and Education;Training Programs;treadmill;Treadmill Tests;Update;Walking;Work

PROJECT_TITLE: Response to Aerobic Exercise in Patients with Pulmonary Hypertension


PROJECT_TERMS: Address;Affect;Age;Agreement;Amendment;arm;Auditory;Behavior;biobank;Biological Markers;Blood;Case Study;Cells;Clinical;clinical phenotype;Cognitive;cohort;Common Data Element;Communities;comorbidity;Contrast Media;Control Groups;Data;data dissemination;Data Set;Databases;demographics;diagnostic biomarker;Diagnostic Imaging;Discourse analysis;Educational Status;Employee;Energy-Generating Resources;Enrollment;Exposure to;flexibility;Future;Gender;Generations;Grant;healthy volunteer;Hematology;Image;inclusion criteria;Individual;Injury;Institutional Review Boards;interest;Language;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Medical History;Natural History;non-verbal;novel diagnostics;Outcome;Outcome Measure;outcome prediction;Participant;Pathology;patient population;Patient Recruitments;Patients;Peer Review;Persons;PET/CT scan;Phenotype;Population;Population Control;Positron-Emission Tomography;Prospective, cohort study;Protocols documentation;Publications;Publishing;Records;recruit;Recruitment Activity;Research;Research Personnel;Resources;Saliva;Sampling;Scanning;Schedule;Series;Serum;Severities;social cognition;study population;Taxonomy;TBI Patients;Techniques;Testing;Time;tomography;Traumatic Brain Injury;Travel;United States National Institutes of Health;vestibular system;Video Recording

PROJECT_TITLE: Long Term Clinical Correlates of TBI: Imaging, Biomarkers, Clinical Phenotyping


PROJECT_TERMS: Aerobic;Aerobic Exercise;Affect;Behavioral;Cell Respiration;Chronic Obstructive Pulmonary Disease;COVID-19 pandemic;Data;Data Analyses;efficacy evaluation;Energy Metabolism;Enrollment;Etiology;Exercise;exercise rehabilitation;Exercise Test;Exercise Therapy;exercise training;Fatigue;Guidelines;health related quality of life;Health Status;Health Surveys;Human Activities;improved;indexing;Interstitial Lung Diseases;Intervention;Life;Lung;Lung Diseases;Manuscripts;Measures;Medical;Metabolic;Modality;Moods;Muscle;Outcome;Outcome Measure;participant enrollment;Patient Care;patient safety;Patients;Pharmaceutical Preparations;Physical activity;Preparation;primary outcome;Protocols documentation;psychosocial;Public Health;Pulmonary Gas Exchange;Pulmonary Hypertension;pulmonary rehabilitation;Questionnaires;recruit;Regimen;Registries;Rehabilitation therapy;Reporting;Research;Research Activity;respiratory;response;Safety;SARS-CoV-2 exposure;secondary outcome;Serious Adverse Event;Severities;standard of care;Suspensions;Symptoms;Test Result;Testing;Time;Training;Training Programs;treadmill;Uncontrolled Study;Walking;Work

PROJECT_TITLE: Exercise Therapy for Advanced Lung Disease Trials: Response and Adaptation to Aerobic Exercise in Patients with Interstitial Lung Disease


PROJECT_TERMS: Adult;Aerobic Exercise;Anaerobic Threshold;Blood flow;Cardiac;Cardiopulmonary;Clinic;Clinical;clinical center;COVID-19 pandemic;Data;Data Analyses;debilitating symptom;Disease;Enrollment;Evaluable Disease;Exercise;Exercise Test;exercise training;Fatigue;Goals;heart function;Heart Rate;Impairment;improved;Information Systems;life span;Lung;Lupus;Manuscripts;Measurement;Measures;Mediating;Motivation;Muscle;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Outcome Measure;Patient Outcomes Assessments;Patients;Perception;Performance;peripheral blood;Physical activity;Physical Function;Pilot Projects;Preparation;primary outcome;Protocols documentation;Pulmonary Gas Exchange;Questionnaires;Recommendation;recruit;Registries;Reporting;Research;Research Activity;Review Committee;secondary outcome;sedentary;Severities;Severity of illness;Sex Bias;social;Stable Disease;Systemic Lupus Erythematosus;Testing;Time;treadmill;United States National Institutes of Health;Visit;Walking;Woman

PROJECT_TITLE: Pilot Study Characterizing Aerobic Exercise in Women with Systemic Lupus Erythematosus (Exercise SLE Pilot)


PROJECT_TERMS: 2019-nCoV;Accelerometer;Aerobic Exercise;Affect;Anxiety;arm;Attention;Biological Markers;Blood;Blood Vessels;Caring;Chest Pain;Chronic;Clinical;Cognition;Cognitive;cognitive testing;Collaborations;Collection;Control Groups;COVID-19;COVID-19 long hauler;COVID-19 survivors;Critical Illness;daily functioning;Dyspnea;Education;Enrollment;Exercise;Exercise Test;exercise training;experience;Failure;Fatigue;follow-up;Functional disorder;functional improvement;Goals;health related quality of life;Hospitalization;improved outcome;Intervention;Length;Long COVID;long term recovery;Measurement;Measures;Mental Depression;metabolomics;Monitor;Muscle;novel coronavirus;Outcome;Outcome Measure;pandemic disease;Participant;participant enrollment;Patient Education;Patient Outcomes Assessments;Patients;persistent symptom;Persons;Phase;Physical activity;Physical Function;physical symptom;Post-Acute Sequelae of SARS-CoV-2 Infection;primary outcome;Procedures;Protocols documentation;psychological symptom;Public Health;Pulmonary Gas Exchange;Quality of life;Randomized;Randomized, Controlled Trials;Recovery;Recovery of Function;recruit;Recruitment Activity;Rehabilitation therapy;Reporting;Research;Research Design;Resources;response;SARS-CoV-2 infection;Scientist;secondary outcome;Serious Adverse Event;Site;sleep health;sleep quality;Symptoms;System;Testing;Time;Training Programs;ultrasound;United States National Institutes of Health;Visit;Waiting Lists;Walking

PROJECT_TITLE: COVID-19, Chronic Adaptation and Response to Exercise (COVID-CARE): A Randomized Controlled Trial


PROJECT_TERMS: Address;Adult;Affect;Age;All of Us Research Program;Ancillary Study;barrier to care;Calibration;cohort;Communities;community engaged approach;community engagement;Community Participation;comorbidity;Data;Development;Disabilities experience;disability;Disabled Persons;evidence base;experience;Family;Feedback;functional disability;functional improvement;General Population;Health;health care availability;Health Care Costs;health care delivery;health data;health disparity populations;Health Status;Healthcare;Healthcare Systems;Income;Individual;information gathering;Insurance Coverage;Intervention;Life;Lived experience;Longitudinal Studies;longitudinal, prospective study;Measures;member;Mental Health;Modification;Outcome;participant enrollment;patient oriented;Patient Self-Report;peer;Phase;Population;Population Group;precision medicine;Process;Research Infrastructure;Self-Help Devices;Shapes;social health determinants;Societies;sociodemographics;Spanish;Surveys;System;therapy development;Translations;Uninsured Medical Expense;Work

PROJECT_TITLE: Longitudinal study of health and functioning among adults with disabilities in All of Us


ACTIVITY: ZIC

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related

PI_NAMEs: KONG, WING PUI  (contact)

PROJECT_TERMS: Animals;Antibodies;Antigens;Autologous;betacoronavirus;Binding;Collaborations;Coronavirus;Coronavirus Infections;Coronavirus spike protein;coronavirus vaccine;Coupling;COVID-19 vaccine;design;Emerging Communicable Diseases;Epitopes;Human;Hybrids;Immunization;Immunize;mosaic;Mus;Mutation;nanoparticle;National Institute of Allergy and Infectious Disease;next generation;pathogen;pre-clinical;Proteins;Sarbecovirus;SARS coronavirus;SARS-CoV-2 spike protein;SARS-CoV-2 variant;self assembly;Self Assessment;Subunit Vaccines;System;vaccine development;vaccine platform;Variant;virology

PROJECT_TITLE: Pre-clinical Vaccine Development for Emerging and Re-emerging Infectious Diseases


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Immunization;Infectious Diseases;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

PROJECT_TERMS: Animals;Antigens;burden of illness;Chimeric Proteins;Cryoelectron Microscopy;design;Discrimination;disulfide bond;Disulfides;Elderly;Engineering;flexibility;Generations;Glycoproteins;Human;human pathogen;Immune response;Immunization;Immunocompromised Host;immunogenicity;improved;Individual;Infection;Macaca mulatta;Modification;mosaic;Mus;Mutation;nanoparticle;Newborn Infant;nonhuman primate;novel;Para-Influenza Virus Type 1;Paramyxovirus;pathogen;Pneumovirus;pre-clinical;Proteins;Publishing;respiratory;respiratory virus;response;Rhesus;self assembly;Site;Structure;Surface;Vaccine Antigen;vaccine candidate;vaccine development;vaccine immunogenicity;vaccine response;Vaccines;Virus

PROJECT_TITLE: Pre-clinical Vaccine Development for Respiratory Viruses


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: DORIA-ROSE, NICOLE  (contact)

PROJECT_TERMS: 2019-nCoV;Animals;Basic Science;Biological Assay;Blood;Clinical Trials;Collaborations;Computer software;COVID-19;cross reactivity;Disease;Dose;Government;Human;human subject;Immunity;Immunize;Immunology procedure;Individual;Laboratories;lonely individuals;Measures;Moderna COVID-19 vaccine;Monoclonal Antibodies;National Institute of Allergy and Infectious Disease;neutralizing antibody;pre-clinical;Prevention;Procedures;Reagent;Research;RNA vaccine;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Serum;Therapeutic;Vaccinated;vaccine candidate;vaccine evaluation;Vaccines;Variant;Viral;virology;Virus;volunteer

PROJECT_TITLE: Quantitative Immunological Assays to Assess SARS-CoV-2 Antibodies and Vaccines


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PI_NAMEs: VANCOTT, THOMAS  (contact)

PROJECT_TERMS: Antigens;Chemistry;Clinical Trials;Contractor;Contracts;Databases;Development;Documentation;Dosage Forms;efficacy study;Equipment and supply inventories;Formulation;Glycopeptides;HIV vaccine;HIV-1;Human;immunogenicity;In Vitro;Investigational Drugs;Laboratories;Laboratory Animals;manufacture;nanoparticle;National Institute of Allergy and Infectious Disease;particle;Phase;plasmid DNA;preclinical development;Preclinical Testing;Preventive vaccine;Process;product development;Production;programs;Proteins;Protocols documentation;prototype;Qualifying;quality assurance;Quality Control;research clinical testing;Running;scale up;stability testing;Sterility;Technology Transfer;Testing;Toxicology;Translations;Vaccines;Viral Vector

PROJECT_TITLE: Synthesize and Produce HIV-1 Envelope Glycopeptide Immunogen Nanoparticle Vaccine(s)


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Patient Safety

ORG_CITY: Durham

ORG_NAME: RHO FEDERAL SYSTEMS DIVISION, INC.

ORG_STATE: NC

PI_NAMEs: YOVETICH, NANCY  (contact)

PROJECT_TERMS: Adverse event;central database;Clinical;Clinical Research;clinical research site;Clinical Trials;Collaborations;Collection;Computers;Consult;Contractor;Contracts;Data;Data Analyses;Data Collection;data management;Data Reporting;design;Development;Devices;experience;Extramural Activities;Human Resources;Intramural Research;Investigational Drugs;Investigational New Drug Application;Knowledge;Laboratory Research;Management Information Systems;Monitor;National Institute of Dental and Craniofacial Research;Operations Research;pharmacovigilance;Phase;Preparation;Procedures;programs;protocol development;Protocols documentation;Quality Control;Reporting;Research;Research Contracts;Research Design;Research Personnel;research study;Resources;Role;Safety;Secure;Serious Adverse Event;Services;Site;sound;Statistical Data Interpretation;System;tool;Training;Update;web site;Work

PROJECT_TITLE: Clinical Research Operations and Management Support (CROMS)


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_NAME: NATIONAL INSTITUTE ON AGING

PROJECT_TERMS: Aging;Censuses

PROJECT_TITLE: Census - Aging


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Physical Injury - Accidents and Adverse Effects

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

ORG_STATE: CA

PI_NAMEs: CHANG, POLLY YEE (contact)

PROJECT_TERMS: animal efficacy;Animal Model;biodosimetry;Contracts;Development;efficacy study;Exposure to;Injury;medical countermeasure;Radiation exposure;Radiation Injuries;Recurrence;Sampling;Services;Testing;Work

PROJECT_TITLE: NON-CLINICAL STUDIES IN SUPPORT OF IND/NDA/BLA SUBMISSIONS


NIH_SPENDING_CATS: Aging;Complementary and Integrative Health;Data Science;Drug Abuse (NIDA only);Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Substance Misuse

ORG_CITY: CHANTILLY

ORG_NAME: FOUR POINTS TECHNOLOGY, LLC

PI_NAMEs: LIPKIN, JOEL A (contact)

PROJECT_TERMS: Acceleration;Address;Biomedical Research;Cloud Computing;Cloud Service;cloud storage;Communities;computerized tools;Data;Data Commons;data ecosystem;data repository;Data Science;Data Set;Economics;FAIR principles;Funding;Goals;Image;Individual;large datasets;Modeling;Modernization;Phase;Policies;Procedures;Process;programs;Research Infrastructure;Research Personnel;Science;Series;service providers;Services;Strategic Planning;Technology;Testing;United States National Institutes of Health;Work

PROJECT_TITLE: STRIDES


NIH_SPENDING_CATS: Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Precision Medicine;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PI_NAMEs: CHUTE, CHRISTOPHER G;HAENDEL, MELISSA A (contact);MOFFITT, RICHARD AUSTIN;PFAFF, EMILY ROSE

PROGRAM_OFFICER_NAME: MCCLAIN, JAMES J

PROJECT_TERMS: Address;Affect;African American population;All of Us Research Program;analytical method;Back;Bayesian Modeling;Biomedical Research;Caring;Classification;Clinical;Clinical Data;cloud based;Collaborations;Communicable Diseases;community intervention;dashboard;Data;data acquisition;Data Collection;data de-identification;data integration;Data Linkages;data pipeline;data quality;Data Set;Data Sources;data streams;design;Diabetes Mellitus;Diagnosis;Disclosure;Electronic Health Record;Enhancement Technology;Ensure;environmental justice;Environmental Risk Factor;experience;Expert Opinion;Federally Qualified Health Center;Foundations;General Population;Genes;Genetic;Genomics;Goals;Health;health data;Health system;Heart Diseases;Hispanic Populations;improved;indexing;Individual;Ingestion;insight;interoperability;Intervention;Iron;Life;Link;Malignant Neoplasms;Measurement;Medicaid;Methods;Modeling;mortality;novel;Opiate Addiction;Outcome;Participant;patient stratification;Patients;Patterns of Care;Persons;Phenotype;precision medicine;Prevention strategy;Privacy;privacy preservation;Process;Prognosis;quality assurance;Recontacts;Recording of previous events;remediation;repaired;Reporting;Research;Research Personnel;Risk;Risk Assessment;Secure;Security;sexual minority;Site;social factors;Source;Standardization;Statistical Models;Stroke;Surveys;Terminology;tool;treatment strategy;Underrepresented Populations;Underserved Population;Uninsured;United States National Institutes of Health;Variant;wearable device

PROJECT_TITLE: Iron-CLAD: securely advancing AoU participant characterization with proven platforms and collaborations


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunotherapy;Lung;Lung Cancer;Precision Medicine;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Lung cancer is the leading cause of cancer mortality in the United States. Targeted therapies, such as growth  factor receptor (EGFR) inhibitors, and immunotherapy have improved survival outcomes, but require genetic  testing as a basis for treatment, which may not be performed equally across patients. We propose to study  disparities in access to genetic testing as one of the ways to explain existing gaps in non-small cell lung cancer  (NSCLC) prognosis between Black and White patients, as well as rural and urban patients.

PI_NAMEs: BENN, EMMA KATHERINE TARA (contact)

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TERMS: access disparities;Address;Adjuvant;anaplastic lymphoma kinase;anti-cancer research;Area;beneficiary;black patient;Black race;BRAF gene;Cancer Etiology;cancer genomics;cancer health disparity;Cancer Patient;Cancer Prognosis;cancer therapy;chemotherapy;clinical practice;Complement;Data;Data Set;design;Disparity;druggable target;education research;Eligibility Determination;Epidermal Growth Factor Receptor;Ethnic Origin;Genetic;genetic testing;Growth Factor Receptors;Health Disparities Research;Hispanic;Histology;Hospitals;Immunotherapy;improved;Incidence;Income;inhibitor;KRAS2 gene;large datasets;Life;Low income;Malignant neoplasm of lung;Malignant Neoplasms;Medicaid;Medicare;Medicare claim;Methods;Minority;Mission;Molecular;mortality;Mutation;Neoplasm Metastasis;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Oncogenic;Operative Surgical Procedures;Outcome;parent grant;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;population based;precision medicine;Prevalence;Procedures;programmed cell death ligand 1;programmed cell death protein 1;programs;Proteins;Quality of Care;Race;Receptor Protein-Tyrosine Kinases;Recommendation;Research;Rural;rural area;Socioeconomic Status;Statistical Data Interpretation;survival disparity;survival outcome;Survival Rate;Systemic Therapy;targeted treatment;Testing;Training;training opportunity;tumor;United States;urban area;Work

PROJECT_TITLE: Cancer research education program (C-REP)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: NARRATIVE The proposed studies are in the area of electrical microstimulation for neuroprostheses, which has potential applications in many human diseases or injuries. Our work will further advance research by generating transformative and efficacious software and hardware technology that will be used widely throughout the research community. Thus, the proposed research is relevant to the translational focus of the NIH's mission and will potentially help to reduce the burdens of human disability.

PI_NAMEs: ORAZEM, MARK E.;OTTO, KEVIN J. (contact)

PROGRAM_OFFICER_NAME: HWANG, GRACE MEI-HUA

PROJECT_TERMS: Address;Area;Charge;Communities;Computer Models;Computer software;design;disability;Electric Stimulation;electrical microstimulation;Elements;Engineering;Evaluation;Goals;Human;human disease;in vivo;Injury;innovation;Measurement;Microelectrodes;microstimulation;Mission;Modeling;Nervous System;neural;Neurons;neuroprosthesis;neuroregulation;Neurosciences;Outcome Assessment;Performance;Research;Resolution;response;Technology;temporal measurement;Testing;tool;United States National Institutes of Health;user-friendly;Work

PROJECT_TITLE: Engineering the Neuronal Response to Electrical Microstimulation


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative In this proposal, our interdisciplinary team proposes to develop and validate innovative methods to advance personalized risk prediction models in the presence of missing and biased EHR data We propose to develop: 1) effective sample-weighting method to correct biases in risk factor selection and estimation for population inferences (Aim 1), 2) flexible deep learning method for EHR personalized risk prediction with fairness criteria (Aim 2); and 3) innovative calibration method to improve reproducibility of EHR-based risk models between institutions (Aim 3). We will assess and validate the developed methods on the New York City Clinical Data Research Network (NYC-CDRN).

PI_NAMEs: SMYTH, PADHRAIC ;ZHONG, HUA JUDY (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TITLE: Personalized Risk Predictions with Deep Learning Methods in the Presence of Missing and Biased Electronic Health Record Data

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse;Vaccine Related

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The combination of COVID-19 and alcohol/substance use disorders exacerbates a wide range of existing problems, including the likelihood of contracting COVID and the severity of consequences, pandemic-related stresses that trigger alcohol and substance use, loss of jobs and healthcare access, and increased interpersonal violence, to name a few. This project will test whether an evidence-based smartphone app that is developed for heavy drinkers plus a family member partner and that offers services related to alcohol/substance use, COVID, and couple behavioral therapy will improve multiple quality of life and drinking measures in comparison to 1) the evidence-based app for heavy drinkers alone minus the couple therapy services and 2) smartphones alone. The proposed study has the potential to impact outcomes for millions of American adults with alcohol and substance use problems, whether in treatment or not, at a time when effective, affordable, accessible interventions are needed more than ever to address the many serious problems likely to persist even after widespread availability of COVID vaccines.

PI_NAMEs: GUSTAFSON, DAVID H (contact);MARES, MARIE-LOUISE

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: addiction;Address;Adult;Adult Children;Al-Anon;Alcohol consumption;alcohol intervention;Alcoholic beverage heavy drinker;Alcohols;American;arm;behavior change;Behavior Therapy;Behavioral;Cellular Phone;Communication;comorbidity;Competence;Conflict (Psychology);Contracts;Control Groups;Couples Therapy;COVID-19;COVID-19 impact;COVID-19 risk;COVID-19 stress;COVID-19 vaccination;COVID-19 vaccine;Data;design;digital health;digital intervention;Disease;drinking;Drug usage;effectiveness testing;evidence base;Evidence based intervention;Family;Family member;Feedback;follow up assessment;follow-up;formative assessment;Funding;Health;health care availability;health disparity;Health Insurance;Healthcare;Heavy Drinking;high risk drinking;Hybrids;implementation science;implementation study;improved;Inequity;Interpersonal Violence;Intervention;Job loss;Measures;Mediating;Mediation;Mediator;member;Modeling;Motivation;Names;National Institute on Alcohol Abuse and Alcoholism;Outcome;pandemic impact;pandemic stress;Perception;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;primary outcome;psychoeducation;psychologic;Quality of life;Randomized;randomized trial;Recovery;recruit;relapse prevention;Resources;response;Risk;risk mitigation;satisfaction;secondary outcome;Service delivery model;Services;Severities;sex;smartphone application;social;Spouses;Stress and Coping;substance use;Substance Use Disorder;Support System;Technology;Telephone;Testing;theories;Time;tool;United States National Institutes of Health;usability

PROJECT_TITLE: Family-focused vs. Drinker-focused Smartphone Interventions to Reduce Drinking-related Consequences of COVID-19

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-M(54)R]


ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Approximately 77,200 Americans will be diagnosed with non-Hodgkin’s lymphoma in 2020 and fewer than half will be cured with conventional treatments. Lymphomas are exquisitely sensitive to radiation and radiolabeled monoclonal antibodies can be very effective at inducing remission in most lymphoma patients, but the disease frequently recurs. This grant proposal describes the development of several innovations that combine radiolabeled antibodies with each other, or with other drugs, to prevent relapse by comprehensively eliminating every lymphoma cell.

PI_NAMEs: GREEN, DAMIAN J. (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: 90Y;absorption;Alpha Particles;American;anti-CD20;anti-tumor immune response;Apoptotic;Applications Grants;Astatine;B lymphoid malignancy;B-Cell Lymphomas;BCL1 Oncogene;BCL2L1 gene;Beta Particle;Biotin;cancer cell;Cancer Vaccines;CAR T cell therapy;Cell Death;cell injury;Characteristics;chimeric antigen receptor T cells;Clinical;clinical translation;Clone Cells;Combination Drug Therapy;combinatorial;Complement;conventional therapy;Deposition;Development;Diagnosis;Disease;Disease remission;Dose;Electromagnetic Energy;experience;Funding;Goals;Grant;Head;Hematologic Neoplasms;Heterogeneity;high risk;human model;Immune;Immune checkpoint inhibitor;Immune response;Immunocompetent;immunogenicity;Immunotherapy;improved;In complete remission;Indolent;inhibitor;innovation;Intervention;Isotopes;large cell Diffuse non-Hodgkin's lymphoma;Length;Linear Energy Transfer;Lymphoma;Lymphoma cell;MCL1 gene;Methods;mimetics;Modeling;Molecular;Monoclonal Antibodies;Monoclonal Antibody CD20;mouse model;Myeloablative Chemotherapy;neoplastic cell;Non-Hodgkin's Lymphoma;novel;Organ;Outcome;particle;particle therapy;Patients;Peptides;peptidomimetics;Pharmaceutical Preparations;programs;Radiation;Radiation Dose Unit;Radiation therapy;Radioimmunoconjugate;Radioimmunotherapy;Radioisotopes;Radiolabeled;Radionuclide therapy;Recurrence;Refractory;Relapse;relapse prevention;Remission Induction;Reporting;Research Proposals;Reserve Cell;Residual Neoplasm;Residual state;Resistance;response;Site;stem cells;Streptavidin;success;Supporting Cell;synergism;Testing;Therapeutic Index;tositumomab;Toxic effect;transcriptome sequencing;Translations;Treatment Efficacy;tumor;Tumor Antigens;Tumor Debulking;tumor xenograft;United States;virtual;Visualization;Work

PROJECT_TITLE: Radioimmunotherapy Combinations for B-cell Malignancy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: No PHR

PI_NAMEs: GROSS, RACHEL SHARON;HORWITZ, LEORA ;KATZ, STUART D (contact);TROXEL, ANDREA B

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: biobank;Bioinformatics;Biometry;Clinical Sciences;Communication;Data Collection;data infrastructure;Data Management Resources;data portal;Data Science;Data Science Core;Epidemiology;Health;open data;Post-Acute Sequelae of SARS-CoV-2 Infection;Quality Control

PROJECT_TITLE: OTA-21-015A Post-Acute Sequelae of SARS-CoV-2 Infection Initiative: NYU Langone Health Clinical Science Core, Data Resource Core, and PASC Biorepository Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: North Bethesda

ORG_NAME: FOUNDATION FOR THE NIH

PI_NAMEs: ADAM, STACEY  (contact)

PROGRAM_OFFICER_NAME: BREEN, JOSEPH J

PROJECT_TERMS: Acceleration;Address;Agreement;Categories;Clinical;Clinical Research;Collaborations;Communication;Communities;community engagement;Congresses;Contracts;design;Educational workshop;effective therapy;Ensure;Evaluation;Feedback;Fostering;Future;Goals;Industry;industry partner;Intellectual Property;Lead;Leadership;Legal;Letters;Long COVID;Mediation;meetings;member;Mission;Modeling;Nonprofit Organizations;Patients;Policies;Privatization;Protocols documentation;public-private partnership;Recovery;Recovery Support;research clinical testing;Research Personnel;Researching COVID to Enhance Recovery;Role;Sampling;Scientist;Selection for Treatments;Structure;Subgroup;Surveys;symposium;Testing;Therapeutic;therapeutic development;United States Food and Drug Administration;United States National Institutes of Health;Universities;volunteer;working group

PROJECT_TITLE: Establishment of a Public-Private Partnership (PPP) to Support Therapy Selection and Testing within RECOVER-TLC


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Data Science;Hematology;Networking and Information Technology R&D (NITRD);Orphan Drug;Rare Diseases;Sickle Cell Disease

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PI_NAMEs: KRONER, BARBARA L (contact)

PROGRAM_OFFICER_NAME: MONDORO, TRACI

PROJECT_TERMS: Advanced Development;Area;Clinical Trials;Common Data Element;Data;Data Collection;data harmonization;data interoperability;data management;data registry;data repository;data resource;data sharing;Data Sources;data standards;Dedications;Development;experience;federated data;gene therapy;Goals;Human;Human Resources;improved;Individual;Infant;innovation;Interdisciplinary Study;International;Knowledge;Leadership;National Heart, Lung, and Blood Institute;patient registry;Patients;programs;Provider;Registries;repository;Research Institute;Research Personnel;Resources;Sickle Cell;Sickle Cell Anemia;United States

PROJECT_TITLE: CURE SICKLE CELL INITIATIVE DATA STRATEGY AND DATA RESOURCES PROGRAM


NIH_SPENDING_CATS: Biotechnology;Hematology;Rare Diseases;Sickle Cell Disease

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PI_NAMEs: CARDOSO, ANGELO A. (contact)

PROJECT_TERMS: Address;Agreement;Annual Reports;assay development;Award;Biotechnology;CD34 gene;cell community;Cells;Cities;Clinical Trials;Communities;cost;Doctor of Philosophy;Ensure;Evaluation;expectation;experience;Funding;gene therapy;Goals;Gold;Human Resources;Infrastructure;interest;Leadership;Lentivirus;manufacture;Manufacturer;Measures;meetings;member;Modification;National Heart, Lung, and Blood Institute;Needs Assessment;Participant;Persons;Process;Production;programs;prospective;Reagent;Research Personnel;Resources;Role;Science;Sickle Cell;Site;Site Visit;Structure;Surveys;symposium;Time;Travel;Treatment Efficacy;United States Food and Drug Administration;vector;Work

PROJECT_TITLE: CureSC Manufacturing Resource Platform


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Uterine Cancer;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PI_NAMEs: BENBROOK, DORIS MANGIARACINA;LESLIE, KIMBERLY K.;MUTCH, DAVID G (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Advocacy;Advocate;Amendment;Bioinformatics;Biometry;Biostatistics Core;Body System;Budgets;career;Caring;Clinical Trials;Collaborations;Committee Members;Communication;Conduct Clinical Trials;Contracts;Decision Making;Development;Documentation;Electronics;Endometrial;Endometrial Carcinoma;Enrollment;Ensure;Equity;Ethics;Fostering;Goals;Grant;Human Resources;innovation;Institution;Institutional Review Boards;Instruction;Malignant Neoplasms;meetings;metabolomics;mindfulness;Mission;National Cancer Institute;New Mexico;Newsletter;next generation;Oklahoma;operation;Participant;Pathology;Patients;payment;programs;Progress Reports;Publications;Reporting;Research;Research Personnel;Route;Services;Site;Specialized Program of Research Excellence;success;Sum;Time;Underrepresented Minority;Universities;Washington;web site


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Rare Diseases;Sickle Cell Disease

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PI_NAMEs: EAPEN, MARY  (contact);HOROWITZ, MARY MARESCA

PROJECT_TERMS: Advocate;biopharmaceutical industry;Caregivers;Collaborations;Communities;Family member;gene therapy;Government Agencies;improved;Individual;innovation;National Heart, Lung, and Blood Institute;Patients;public-private partnership;Research Personnel;Sickle Cell;Sickle Cell Anemia;Technology;Work

PROJECT_TITLE: Cure Sickle Cell


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Complementary and Integrative Health;Genetics;Neurosciences;Pain Research

PI_NAMEs: CHESLER, ALEXANDER  (contact)

PROJECT_TERMS: afferent nerve;Afferent Neurons;Alleles;allodynia;Architecture;Biological Models;Biology;Brain;Brain region;Cell Line;Cells;Collaborations;Detection;detection platform;Development;Disease;exome sequencing;Frequencies;Functional Imaging;Genes;Genetic;Goals;Hair;Human;Hyperalgesia;Image;in vivo;Inflammation;Inherited;Injury;insight;Interoception;Ion Channel;Ion Channel Gating;Life;Link;Maps;mechanical stimulus;Mechanics;millimeter;model organism;Molecular;Monitor;Morphology;mouse genetics;Movement;Mus;Muscle;Mutation;National Institute of Neurological Disorders and Stroke;neurochemistry;Neuromuscular Diseases;Neurons;Nociception;Organ;Pain;patient screening;Patients;Peripheral;Physiological;Physiology;Piezo 2 ion channel;Play;Proprioception;Proprioceptor;receptor;Research;Role;Sensory;sensory stimulus;Skin;somatosensory;Stimulus;Stretching;Temperature;Tendon structure;Testing;Tissues;Touch sensation;Translating;Well in self

PROJECT_TITLE: Studies on the molecular, cells, and circuit that underlie somatosensation and pain


NIH_SPENDING_CATS: Chronic Pain;Complementary and Integrative Health;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

PI_NAMEs: CARRASQUILLO, YARIMAR  (contact)

PROJECT_TERMS: Absence of pain sensation;Acute Pain;Address;Affective;affective disturbance;Amygdaloid structure;Analgesics;Anatomy;Automobile Driving;Behavior;Behavioral;Behavioral Model;behavioral response;Brain;Brain region;cell type;Cells;chronic neuropathic pain;chronic pain;chronic pain patient;Colitis;Collaborations;comorbidity;Computer Models;Dimensions;Disease Progression;Electrophysiology (science);expectation;experience;experimental study;Goals;Hypersensitivity;Image;in vivo;Inflammation;Injury;Intestines;Link;Maintenance;Modeling;Molecular;Molecular Genetics;Morphology;Mus;nerve injury;Neurons;Nociception;novel;Pain;pain chronification;Pain management;pain processing;parabrachial nucleus;Pathology;Pathway interactions;Peripheral;Population;Population Decreases;Positioning Attribute;programs;Prosencephalon;Publishing;Reducing Agents;Reporting;Research;response;severe injury;sex;sex as a biological variable;Sex Differences;Signal Transduction;simulation;Site;Solid;somatosensory;Stimulus;Stress;Structure;Subthalamic structure;Synapses;System;Texas;Tobacco;Visceral;Work;zona incerta

PROJECT_TITLE: Molecular and cellular mechanisms for bidirectional control of pain in the brain


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Complementary and Integrative Health;Mental Health;Neurosciences;Pain Research

PI_NAMEs: ATLAS, LAUREN  (contact)

PROJECT_TERMS: Acute Pain;Affective;affective neuroscience;Animal Model;Atlases;Attention;Brain;Calibration;Central Nervous System;Clinical;Cognitive;Computer Models;contextual factors;Cues;Data Collection;Decision Making;design;Dissociation;Eligibility Determination;emotional experience;Emotions;Enhancing Lesion;Expectancy;expectation;experience;Experimental Psychology;experimental study;Feedback;Female;Functional Magnetic Resonance Imaging;Goals;heat stimulus;hedonic;Human;human model;human subject;Individual;Instruction;interest;Journals;Learning;Lesion;Link;male;Manuscripts;matriculation;Measures;Mediating;Modality;Nervous System;neural;neurobiological mechanism;Neurobiology;neuroimaging;neuromechanism;Neurosciences;Organism;Outcome;Pain;Pain management;pain perception;pain processing;pain relief;pain sensitivity;Pain Threshold;Paper;Participant;Pathway interactions;Patient Self-Report;Patient-Focused Outcomes;Physiological;Pilot Projects;placebo analgesia;Placebo Effect;Placebos;Population;Postbaccalaureate;Postdoctoral Fellow;pre-doctoral;Prefrontal Cortex;Procedures;Progress Reports;Protocols documentation;psychologic;Psychological Factors;Psychophysiology;Publishing;Questionnaires;recruit;Reporting;Research;Research Design;response;screening;Sex Differences;Shapes;Shock;Signal Transduction;Stimulus;Taste Perception;Temperature;Testing;verbal;Visit;Work

PROJECT_TITLE: Neural and psychological mechanisms of pain perception


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Complementary and Integrative Health;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pain Research;Social Determinants of Health

PROJECT_TERMS: American;Atlases;Belief;Clinic;contextual factors;COVID-19 pandemic effects;Cues;Data;Environment;Ethnic Origin;expectation;Geography;health disparity;Healthcare;Image;Inequity;Laboratories;Manuscripts;Measures;Mental Health;National Institute of Mental Health;Pain;Pain Measurement;pain outcome;pain relief;pandemic disease;Paper;Patients;Perception;Persons;physical conditioning;Placebo Effect;Population Heterogeneity;Process;Protocols documentation;Provider;Research Activity;Research Design;Sampling;Social Environment;social influence;Social isolation;socioeconomics;Stereotyping;Stimulus;Survey Methodology;Surveys;Testing;Visual;Work

PROJECT_TITLE: Large-Scale Online stimulus Norming and Surveys about Perceptions in Healthcare


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pain Research;Social Determinants of Health

PROJECT_TERMS: Address;adverse outcome;Affect;Algorithmic Software;Amendment;Arousal;Attention;Behavioral;biobehavior;Biological;Biological Factors;Biological Process;Black Populations;Computer Models;Data;Data Analyses;Data Collection;Databases;directed attention;Disease;Disparity;Disparity population;doctoral student;efficacy testing;Empathy;Environment;experience;Face;Feedback;Fellowship;forging;Foundations;Functional Magnetic Resonance Imaging;Galvanic Skin Response;gaze;Health;health disparity;Health Personnel;healthy volunteer;Image;improved;Individual;insight;Institutional Review Boards;Instruction;Intervention;Learning;Link;Manuscripts;Measures;Medical;minority patient;Movement;Mydriasis;non-verbal;outcome disparities;Pain;Pain intensity;Pain management;Pain Measurement;pain perception;pain reduction;Pain Research;Pain Threshold;Participant;Physiological;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;Process;programs;Protocols documentation;Provider;Psychophysiology;psychosocial;public database;Reporting;Research;Research Design;response;Role;Series;Shapes;social;social culture;social factors;social neuroscience;Social Processes;sociocultural determinant;Stimulus;Symptoms;Testing;therapy design;Visual attention;visual tracking;volunteer;Work

PROJECT_TITLE: Sociocultural & biobehavioral influences on pain expression and assessment


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pain Research;Social Determinants of Health

PROJECT_TERMS: Affect;Benchmarking;biobehavior;computer generated;Data;Data Set;Databases;Demographic Factors;Disparity;diverse data;Emotions;experience;Facial Expression;Facial Pain;Future;Goals;health disparity;Image;Individual;Institutional Review Boards;Judgment;Laboratories;Learning;Literature;Mechanics;Modality;Pain;Pain Measurement;pain perception;Painless;Participant;Perception;Persons;Pilot Projects;Process;programs;Protocols documentation;psychologic;Publishing;Research;showing emotion;social;social culture;social factors;Social Processes;sociocultural determinant;sociodemographic factors;Stimulus;Surveys;Testing

PROJECT_TITLE: Evaluating perception of pain-related social stimuli


ORG_NAME: CLINICAL CENTER

PI_NAMEs: BIASSOU, NADIA  (contact)

PROJECT_TERMS: Adult;Age;American;Attention;Auditory;auditory processing;Automobile Driving;Bilateral;Brain;Brain Mapping;brain size;brain tissue;central nervous system injury;Cerebral hemisphere;Clinical;Cognitive;cohort;computational network modeling;Computer Models;connectome;Contralateral;Data;Data Set;Databases;Educational Status;Elderly;Epilepsy;Gender;Goals;healthy volunteer;Hearing;Human;imaging modality;Individual;Injury;Institutional Review Boards;interest;Intervention;Journals;Language;language processing;Legal patent;Machine Learning;Manuscripts;mental state;National Institute of Neurological Disorders and Stroke;neural network;neuromechanism;Neurons;Neurosciences;Operative Surgical Procedures;Outcome;Pathway Analysis;Patients;Performance;Protocols documentation;Recovery;recruit;Rest;Risk;Seizures;Side;simulation game;Speech;Statistical Data Interpretation;surgical risk;symposium;Testing;Time;Work

PROJECT_TITLE: Using Static and Dynamic connectivity analyses of Eloquent brain tissue to assess surgical risk in patients with intractable seizures


PI_NAMEs: BULEA, THOMAS  (contact)

PROJECT_TERMS: Amendment;Ankle;Architecture;biomechanical test;Biomechanics;Bionics;Brain;Canada;Cerebral Palsy;Child;Childhood;Clinical;cohort;Cohort Studies;Cooperative Research and Development Agreement;crouch gait;Custom;Data Collection;design;Devices;direct application;Electroencephalography;Evaluation;Excision;exoskeleton;Extensor;Flexor;foot;Future;Gait;gait rehabilitation;Gait speed;Generations;improved;Intervention Trial;Knee;Knee joint;Length;Marketing;Movement Disorders;Muscle;Muscular Dystrophies;neuromuscular;novel;novel strategies;operation;Orthotic Devices;Outcome Measure;pandemic disease;Participant;Phase;Population;primary outcome;Protocols documentation;prototype;recruit;Research;research clinical testing;Research Design;Resistance;resistance exercise;response;Risk;Risk Assessment;robot exoskeleton;robotic device;Robotics;Scheme;secondary outcome;sensor;Spinal cord injury;Spinal Dysraphism;Technology;Time;Torque;United States National Institutes of Health;Visit;Walking

PROJECT_TITLE: Evaluating a pediatric exoskeleton to improve walking function in children with movement disorders


PROJECT_TERMS: Adult;Articular Range of Motion;Biomechanics;Categories;Cerebral Palsy;Child;Childhood;Classification;Clinic;Clinical;clinical center;Communities;Computers;Cross-Over Studies;Cross-Over Trials;crouch gait;design;Devices;Diagnosis;Disability Evaluation;Disease;dosage;Educational Intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Electronics;Enrollment;Equipment and supply inventories;exoskeleton;Extensor;Flexor;Freedom;functional improvement;Gait;gait rehabilitation;Gait speed;Genetic Crossing Over;Goals;Home;Hour;improved;Intervention;Isometric Exercise;Knee;Knee joint;laboratory experience;Length;Limb structure;Measures;Monitor;Motor;Movement Disorders;Muscle;Muscle Spasticity;muscle strength;Muscular Dystrophies;neurological rehabilitation;neuromuscular activity;Neuromuscular Diseases;novel;Orthotic Devices;Outcome Assessment;Outpatients;Participant;patient population;Patients;Phase;Phase I/II Trial;Physical Medicine;post intervention;Posture;primary endpoint;Procedures;Protocols documentation;Randomized;recruit;rectus femoris;Rehabilitation therapy;Research Design;robot exoskeleton;Robotics;Safety;safety and feasibility;sensor;Site;Spinal cord injury;Spinal Dysraphism;strength training;Structure;System;Target Populations;Technology;Testing;Time;Torque;Training;United States National Institutes of Health;vastus lateralis;Visit;Walking;Withdrawal

PROJECT_TITLE: A phase I/II trial evaluating long-term use of a Pediatric Robotic Exoskeleton (P.REX/Agilik) to improve gait in children with movement disorders


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

PI_NAMEs: NEWMAN, AMY HAUCK (contact)

PROJECT_TERMS: abuse liability;Affect;Affinity;analog;Animal Model;associated symptom;Attention;Attention deficit hyperactivity disorder;Axon;Behavior;Behavioral;Benztropine;Binding;Brain;brain tissue;Cardiotoxicity;Carrier Proteins;Cells;Citalopram;Clinic;Clinical Treatment;Cocaine;Cocaine Abuse;Cocaine Dependence;Cocaine misuse;Cocaine use disorder;Computer Models;computer studies;design;Detection;Development;Disabling;Disease;DNA Sequence Alteration;Dopamine;dopamine transporter;Dopamine Uptake Inhibitors;Drug Design;drug discovery;Drug Kinetics;Effectiveness;Electrophysiology (science);Endoplasmic Reticulum;Exhibits;experimental study;Flow Cytometry;fluorophore;Food;Human;Human Genetics;Ibogaine;improved;in vivo;inhibitor;insight;Intake;Label;Lead;Ligands;Macaca mulatta;Measures;Membrane;Metabolic;Metabolism;Methamphetamine;methamphetamine abuse;Methamphetamine dependence;Modafinil;Modeling;Modification;Molecular;Molecular Conformation;Monkeys;monoamine;monocyte;motor disorder;Movement Disorders;Mus;mutant;neurochemistry;Neurons;neuropsychiatric disorder;nisoxetine;nonhuman primate;noradrenaline transporter;Norepinephrine;novel;novel therapeutics;off-label use;Oregon;Parents;patch clamp;Patients;peripheral blood;Pharmaceutical Preparations;pharmacologic;Pharmacology;pharmacophore;Procedures;Property;Proteins;psychostimulant;Publishing;Rattus;reduce symptoms;reuptake;Rhodamine;Rodent;Rodent Model;Role;scaffold;screening;Selective Serotonin Reuptake Inhibitor;Series;Serotonin;serotonin transporter;Sleep Disorders;Slice;small molecule;Stimulant;stimulant use disorder;Structure;Structure-Activity Relationship;Study models;success;superresolution imaging;superresolution microscopy;tool;trafficking;Translations;Tropanes;Visualization;Work

PROJECT_TITLE: Novel Probes for the Monoamine Transporters


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

PROJECT_TERMS: Absence of pain sensation;addiction liability;Affinity;Agonist;Amides;Amino Acids;Analgesics;analog;antagonist;Attention;Behavioral;Binding;Binding Sites;Biological Assay;Biological Availability;Bipolar Disorder;blood-brain barrier penetration;Brain;Brain region;Cells;Chimera organism;Chromatography;Cocaine;cocaine seeking;cocaine self-administration;comorbidity;Computer Models;Coupled;Cryoelectron Microscopy;Data;design;Development;Diagnosis;Disorientation;Dopamine;Dopamine D2 Receptor;Dopamine Receptor;DRD2 gene;Drug Design;drug discovery;Drug Kinetics;Effectiveness;enantiomer;eticlopride;Evaluation;extracellular;Family;Future;Goals;GTP-Binding Proteins;improved;in vivo;in vivo Model;Indoles;interest;Investigation;Investigational New Drug Application;Ion Channel;Kinetics;Lead;Learning;Ligand Binding;Ligands;Link;Loperamide;member;Mental disorders;Metabolic;Methamphetamine;Microsomes;Modeling;Modification;Mood Disorders;Motor;mu opioid receptors;neuropsychiatric disorder;Neurotransmitters;new therapeutic target;next generation;nonhuman primate;novel;Opiate Addiction;Opioid;Opioid Antagonist;opioid misuse;opioid use disorder;oxycodone self-administration;Parents;patient population;Patients;Penetrance;Penetration;Pharmaceutical Preparations;pharmacologic;Pharmacology;pharmacophore;phenylpiperazine;Physiological;Piperazines;Play;pre-clinical;preference;prescription opioid addiction;prevent;Property;Proteins;Publishing;Rattus;receptor;Reporting;Rewards;Risk;Rodent Model;Role;scaffold;Schizophrenia;Series;side effect;Site;Site-Directed Mutagenesis;small molecule;Stimulant;stimulant use disorder;Structure;Substance Use Disorder;substance use treatment;Sumanirole;Testing;Therapeutic;therapy development;tool;Translations;Transmembrane Domain;Treatment Efficacy;Withdrawal;Work

PROJECT_TITLE: Novel Dopamine D3/D2 Receptor Ligands


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Digestive Diseases;Kidney Disease;Osteoporosis;Rare Diseases;Women's Health Research

PI_NAMEs: TEN HAGEN, KELLY G (contact)

PROJECT_TERMS: 25-hydroxyvitamin D;absorption;Acetylgalactosamine;activation-induced cytidine deaminase;Adaptor Signaling Protein;Affect;American;Anabolism;Animals;Behavior;Binding;Binding Proteins;Biochemistry;Biological;Blood;bone;Bone Density;Bone Development;Bone Diseases;Bone remodeling;C-terminal;calcification;Calcium;Calcium ion;Cells;Chronic Kidney Failure;Colon Carcinoma;Congenital Heart Defects;cortical bone;Cysteine;Cysteine-Rich Domain;Cystic Fibrosis;Cytoplasmic Granules;Defect;Development;Dihydroxycholecalciferols;Disease;Disease Progression;Disease susceptibility;Drosophila genus;egg;Enzymes;Epithelium;Extracellular Matrix Proteins;Familial tumoral calcinosis;Family;Female;female reproductive system;female reproductive tract;functional decline;GALNT3 gene;Gastrointestinal tract structure;Genes;genome wide association study;Gland;glycosylation;glycosyltransferase;High Density Lipoprotein Cholesterol;Homeostasis;Hormones;human disease;hydroxyl group;in vivo;Inflammatory Bowel Diseases;inorganic phosphate;insight;Journals;Kidney;Kidney Diseases;LDL-Receptor Related Protein 2;Lectin;Ligands;Link;male;Mammals;Maps;mating behavior;Mediating;member;Membrane;Minerals;model organism;Modeling;Molecular Weight;Morphology;mouse model;Mucins;Mus;Mutation;Neoplasm Metastasis;novel;Organ;organ growth;Osteogenesis;Osteomalacia;Osteoporosis;Partner in relationship;Physiological;Play;Polysaccharides;Population;Post-Translational Protein Processing;Production;Proteins;Proteinuria;PTH gene;Publishing;receptor;reproductive tract;Research;Respiratory Disease;Respiratory Tract Diseases;response;Rickets;Role;role model;Salivary Glands;Science;Secretory Vesicles;Seminal;Seminal fluid;Serine;Serum;skeletal;Skeletal system;small molecule;sperm cell;Sperm Tail;substantia spongiosa;sugar;Surface;Syndrome;Text;Threonine;Tissues;treatment strategy;Triglycerides;tumor progression;Vitamin D;Vitamin D-Binding Protein;Work

PROJECT_TITLE: Role of O-glycosylation in Animal Development


NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

PI_NAMEs: MOUTSOPOULOS, NIKI  (contact)

PROJECT_TERMS: Adverse effects;Autoimmune Diseases;Clinical;clinical center;clinical phenotype;Clinical Research;cohort;Collaborations;Color;congenital immunodeficiency;CXCL9 gene;Defect;Dental Clinics;Disease;disease phenotype;Disease remission;Disease susceptibility;early onset;Environment;Evaluation;Genes;Health;Human;Immune;Immune response;Immune System Diseases;Immunity;Immunologics;Immunophenotyping;interest;Interferon Type II;ITGB2 gene;Janus kinase;kinase inhibitor;Laboratories;Link;loss of function mutation;microbial;Mouth Diseases;Mucosal Immune Responses;Mucositis;Mucous Membrane;Mutation;Mycoses;National Institute of Allergy and Infectious Disease;neutrophil;Oral;Oral cavity;Oral Characters;oral fungal;oral microbiome;Oral mucous membrane structure;oral tissue;Oral Ulcer;Pathogenicity;Pathway interactions;patient population;Patients;Periodontal Diseases;Periodontitis;Phenotype;Polyglandular Autoimmune Syndrome Type I;Predisposition;Research Personnel;Role;Science;single cell sequencing;T-Lymphocyte;therapeutic target;Tissues;translational study;United States National Institutes of Health;Virus Diseases;Work

PROJECT_TITLE: Oral Microbial and Immunological Characterization of Patients with Immune Dysfun


NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Primary Immunodeficiencies;Rare Diseases

PROJECT_TERMS: Affect;American;bench to bedside;bone;Cells;Chronic;Clinical Trials;Connective Tissue;cytokine;Dentition;Disease;Distal;dysbiosis;Elements;Epithelial Cells;Epithelium;Flagellin;Gene Mutation;General Population;Gingiva;Health;Health Care Costs;Human;IL17 gene;Immune;Immunity;Impairment;Individual;Inflammation;Inflammatory;Inflammatory Response;insight;interest;interleukin-23;Interleukin-6;ITGB2 gene;Leukocyte Adhesion Deficiency;Link;Mediating;Microbe;microbial;microbiome;microbiota;migration;Modeling;Molecular;Mucous Membrane;neutrophil;Oral;oral immunity;oral microbiome;Oral mucous membrane structure;Pathogenesis;Pathogenicity;Pathology;Periodontitis;Population;Predisposition;programs;Quality of life;Research;response;Role;Site;Source;Structure;Testing;Therapeutic;Tissues;Tooth Loss;Tooth structure;Virulence Factors;Work

PROJECT_TITLE: Mechanisms of Chronic Inflammation in Periodontitis


NIH_SPENDING_CATS: Cancer;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Neuroblastoma;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: KEROSUO, LAURA  (contact)

PROJECT_TERMS: Biochemical;Biological Assay;Cell Maintenance;Cells;Cellular biology;Chick;Chick Embryo;Communication;Congenital Abnormality;Cytoskeleton;Development;Developmental Process;DiGeorge Syndrome;Disease;Ectoderm;Embryo;Event;gastrulation;gene regulatory network;Genes;Genotype;Germ Layers;Goals;Heterogeneity;Human;Human Development;human embryonic stem cell;Image;In Vitro;in vivo Model;induced pluripotent stem cell;interest;knock-down;Knowledge;Malignant Neoplasms;Methodology;Modernization;Molecular;Molecular Biology;Molecular Biology Techniques;Mus;Nature;Neural Crest;Neural Crest Cell;Neuroblastoma;novel;Pathology;Pathway interactions;Patients;Pattern;pluripotency;Process;Publishing;Research;Role;Signal Transduction;stem cells;Technology;transcriptomics;Ubiquitin;Work

PROJECT_TITLE: Neural Crest Development and Disease


NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human

PI_NAMEs: TUSSIWAND, ROXANE  (contact)

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;Antigen Presentation;Antigen-Presenting Cells;Antigens;Autoimmune Diseases;Autoimmunity;Bone Marrow;Cells;Cellular biology;clinical practice;Complex;Cues;cytokine;Dendritic Cells;Development;draining lymph node;Effector Cell;Ensure;Epithelial Cells;Equilibrium;frontier;Gene Expression Profile;Genetic Transcription;Hematopoietic;Heterogeneity;Human;human disease;Immune;Immune response;Immune system;Immune Targeting;Immunity;Immunologics;immunoregulation;Immunotherapy;improved;in vivo;inflammatory milieu;Inflammatory Response;interest;Interferon Type I;Knowledge;Link;Macrophage Colony-Stimulating Factor;Maintenance;mouse model;Mus;Natural Immunity;novel;pathogen;Pathway interactions;Pattern recognition receptor;personalized medicine;Phase;Play;Production;progenitor;Property;Psoriasis;recruit;Research;response;Role;self-renewal;Site;Skin;Source;Specific qualifier value;Specificity;stem cells;T-Lymphocyte;Tissues;transcription factor;Transcriptional Regulation;Translating;tumor;Tumor Immunity;uptake;vaccine strategy;Viral;Virus Diseases

PROJECT_TITLE: Dendritic cells heterogeneity and function


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Disability Research;Pediatric;Prevention;Rare Diseases

PI_NAMEs: BOYCE, ALISON  (contact)

PROJECT_TERMS: Adult;Antibodies;Biological Models;Blood;bone;Bone Diseases;Caring;Cell Proliferation;Child;Child Welfare;Childhood;Clinical;Clinical Trials;Complex;Cyclic AMP;Development;disability;Disease;Endocrine System Diseases;Enrollment;Fibrous Dysplasia;G-Protein-Coupled Receptors;gain of function mutation;Goals;Health;Hormones;Hypercalcemia;Hypophosphatemia;improved;Individual;Knowledge;Lead;Lesion;Ligands;McCune-Albright Syndrome;Medical;Metabolic Bone Diseases;Mission;Morbidity - disease rate;Mosaicism;Natural History;novel;novel therapeutic intervention;Osteoclasts;osteoprogenitor cell;Pathogenesis;Patients;phase II trial;Phosphorus;Physiological;Physiology;prevent;Proliferating;Quality of life;Rare Diseases;Retrospective Studies;Role;Signal Pathway;skeletal;skeletal disorder;TNFSF11 gene;tool;translational study;Variant;Work

PROJECT_TITLE: Metabolic Bone Disorders Unit


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Estrogen;Health Services;Hypertension;Infectious Diseases;Machine Learning and Artificial Intelligence;Menopause;Osteoporosis;Patient Safety;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Urologic Diseases;Women's Health Research

ORG_NAME: NATIONAL LIBRARY OF MEDICINE

PI_NAMEs: MCDONALD, CLEMENT  (contact)

PROJECT_TERMS: Address;Adrenergic alpha-Antagonists;Adrenergic beta-Antagonists;Adult;Adverse drug effect;Adverse effects;alfuzosin;Alzheimer's Disease;Ambulatory Care;Angiotensin-Converting Enzyme Inhibitors;Anti-Hypertensive Agents;Anticoagulants;Antiplatelet Drugs;beneficiary;Benefits and Risks;Benign Prostatic Hypertrophy;Big Data;bisphosphonate;Bone Density;Bone structure;Breast;Calcium Channel Blockers;Cardiovascular Diseases;Cessation of life;Chronic;Chronic Disease;Clinical;clinical database;Clinical Trials;cognitive function;Cohort Studies;comparative effectiveness;Consensus;COVID-19;COVID-19 severity;Cox Models;Cox Proportional Hazards Models;Data;Data Analyses;Deterioration;Diagnosis;Disease;disease diagnosis;Diuretics;drug maintenance;Drug usage;effective therapy;Elderly;Elderly woman;Enrollment;Epidemiology;Estrogens;Event;Female;Femoral Fractures;flu;follow-up;Fracture;fracture risk;frailty;Goals;Guidelines;hazard;Health;health care service utilization;Hip region structure;Hormone replacement therapy;Hot flushes;human old age (65+);Hyperlipidemia;Hypertension;Hypogonadism;Incidence;indexing;Informatics;informatics infrastructure;Life;Lipids;Long COVID;Longevity;lower urinary tract symptoms;machine learning method;male;Malignant neoplasm of prostate;Malignant Neoplasms;Masks;Medicare;medication safety;men;Menopause;Methodology;Methods;molnupiravir;Moods;mortality;mortality risk;muscle form;muscle strength;Myocardial Ischemia;neural network;Neurodegenerative Disorders;Night Sweating;nirmatrelvir;older patient;Osteoporosis;Outcome;Parkinson Disease;Pathogenesis;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;Pharmacotherapy;post-COVID-19;Postmenopausal Osteoporosis;Prevention;Progestins;Prostatic hypertrophy;Publishing;Pythons;Raloxifene;Recommendation;Reference Values;Regression Analysis;Reporting;Research;Rheumatism;Risk;Risk Estimate;rituximab;SARS-CoV-2 infection;Sex Functioning;Stroke;Survival Analysis;symptomatic improvement;symptomatology;Symptoms;Syndrome;tamsulosin;terazosine;Testing;Testosterone;testosterone replacement therapy;Thinness;Time;tocilizumab;United States Food and Drug Administration;Update;Urology;venous thromboembolism;women's treatment

PROJECT_TITLE: Clinical and Informatics Research on Large Clinical Databases


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Cancer;Data Science;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases;Sickle Cell Disease;Tuberculosis

PI_NAMEs: ANTANI, SAMEER  (contact)

PROJECT_TERMS: Address;Adult;Affect;Anatomy;Appearance;Architecture;Area;Artificial Intelligence;artificial intelligence algorithm;automated segmentation;biomedical imaging;Biomedical Research;Biopsy;Cancerous;Cardiac;Cardiovascular Diseases;Characteristics;Child;Childhood;Classification;Clinical;clinical decision-making;Code;Collaborations;Communicable Diseases;comorbidity;Complex;computer-assisted diagnostics;COVID-19 detection;Darkness;Data;data quality;Data Set;Decision Making;deep learning;deep learning model;Dentists;design;Detection;Devices;Diagnosis;Diagnostic;diagnostic tool;Disease;Echocardiography;Entropy;Evaluation;forgetting;General Population;generative artificial intelligence;global health;Goals;health application;Histopathology;HIV;Human;Image;Image Analysis;Image Enhancement;image processing;Imaging Device;Impairment;improved;indexing;innovation;insight;interest;International;Kaposi Sarcoma;Lateral;Learning;learning network;Legal patent;Lesion;Literature;Location;Lung;Machine Learning;machine learning method;Malignant - descriptor;malignant mouth neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Medical Imaging;Metadata;Methods;Modality;model generalizability;Modeling;mortality;multidimensional data;multimodality;National Institute of Allergy and Infectious Disease;National Institute of Dental and Craniofacial Research;novel;Oncology;Oral;Oral cavity;Outcome;Patients;Performance;Population;Population Heterogeneity;portability;pre-trained model;premalignant;Process;Property;Pulmonary Edema;Quality Control;radiologist;Real-Time Systems;Research;Resource-limited setting;Role;Running;Sampling;self supervised learning;Semantics;Sickle Cell Anemia;Skin;Source;synthetic data;task analysis;Techniques;Testing;Text;Thoracic Radiography;Tissues;Training;training data;treatment planning;Tuberculosis;Ultrasonography;United States National Institutes of Health;Update;Variant;Visualization;Weight;Woman;Work;X-Ray Medical Imaging

PROJECT_TITLE: Machine learning and artificial intelligence research for clinical medical image processing


NIH_SPENDING_CATS: Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: DEMNER-FUSHMAN, DINA  (contact)

PROJECT_TERMS: Abbreviations;Access to Information;Address;Administrator;Affect;Anatomy;breast exam;California;Characteristics;Child;Clinical;clinical decision support;clinical decision-making;clinically relevant;Clip;Collaborations;Collection;Communities;Computational Linguistics;Data;Data Analyses;Databases;deep learning;Disease;Education;Educational process of instructing;Educational workshop;Emotional;Evaluation;Evidence Based Medicine;Eye;Family;Formulation;Foundations;Generations;Goals;Growth;Health;History of Medicine;Home;Hybrids;Image;improved;Indiana;Instruction;interest;International;Intervention;Knowledge;Label;Language;language processing;large language model;Lead;Literature;Location;machine learning method;Malignant Breast Neoplasm;Medical;Medical Libraries;Medicine;MedlinePlus;Methods;model organism;Modeling;Names;Natural Language Processing;neural;novel strategies;Orthopedics;Outcome;Paper;Patients;Persons;Pharmaceutical Preparations;prototype;Publications;PubMed;radiological imaging;Radiology Specialty;Reporting;repository;Research;Resources;Retrieval;Role;search engine;Services;Social support;Source;spelling;Study Subject;supervised learning;support network;System;systematic review;Techniques;Testing;Text;Thoracic Radiography;tool;Training;Translating;Translations;United States National Institutes of Health;United States National Library of Medicine;Universities;Update;Visual;Writing

PROJECT_TITLE: Providing timely and effortless access to reliable health-related information for decision support and education


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

PI_NAMEs: WEISS, JEREMY  (contact)

PROJECT_TERMS: Accounting;Active Learning;Address;Agreement;Algorithms;Artificial Intelligence;censorship;Classification;Clinical;clinical care;Clinical Data;clinical predictors;clinical risk;Collection;Critical Care;Data;Data Element;data quality;Data Science;Data Set;Dependence;Disease;Disease Progression;Dropout;Electronic Health Record;Environment;Equity;Event;follow-up;Goals;graph neural network;Healthcare;human-in-the-loop;improved;Individual;inpatient service;large language model;Machine Learning;machine learning method;machine learning model;Measures;Methodology;Modeling;multimodal learning;opioid abuse;Outcome;Patients;Performance;pharmacovigilance;Pilot Projects;prediction algorithm;prevent;Process;Research;Research Personnel;Resources;Risk;risk prediction;Sepsis;Survival Analysis;Text;Time;Training;Translations;Variant;Visualization;Work

PROJECT_TITLE: Machine learning methods in data science for clinical prediction and characterization


NIH_SPENDING_CATS: Bioengineering;Data Science;Infectious Diseases;Networking and Information Technology R&D (NITRD)

PI_NAMEs: YU, YI-KUO  (contact)

PROJECT_TERMS: Address;Agreement;Algorithms;American;Antibiotic Resistance;Antibiotics;Area;Back;Berlin;Biological;Biological Markers;Biomass;Biomedical Research;clinical center;clinical diagnosis;Collaborations;Committee Members;Computational algorithm;Computational Biology;Computer software;Data;Data Analyses;data visualization;Databases;deep learning;design;Evaluation;expectation;experimental study;Feedback;Forensic Medicine;Goals;graphical user interface;improved;Information Retrieval;instrument;International;Ions;Isotopes;Journals;Label;Maps;mass spectrometer;Mass Spectrum Analysis;Mathematics;Measures;member;Metadata;metaproteomics;Methods;Microbe;microbial;microorganism;microorganism classification;National Heart, Lung, and Blood Institute;National Security;Pacific Northwest;Paris, France;pathogen;Peptide Fragments;Peptides;Performance;Phase;Posttranslational Amino Acid Modification;prevent;programs;Proteins;Proteome;Proteomics;Public Health;Publications;Publishing;Reporter;Reporting;Reproducibility;Research;Safety;Sampling;Scientist;Sensitivity and Specificity;Signal Transduction;Societies;Speed;Standardization;statistics;Sum;Sweden;Systems Biology;tandem mass spectrometry;Textbooks;Time;tool;United States National Institutes of Health;Universities;usability;Weight;Work;Writing

PROJECT_TITLE: Robust Accurate Identification of peptides from tandem mass spectrometry data


NIH_SPENDING_CATS: Bioengineering

PROJECT_TITLE: Physical Foundation of Biomolecular Interactions