ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Having health workers assist HIV-infected persons with the recruitment and testing of their sexual contacts and biological children is an effective and efficient way of identifying persons in need of HIV treatment and prevention. However, in Malawi, a country with a generalized HIV epidemic, health workers lack the counseling and coordination skills to routinely assist their HIV-infected clients with these services. This study will determine how to help health workers in Malawi to provide these services through a set of digital capacity-building tools.

PI_NAMEs: ROSENBERG, NORA  (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adopted;Adoption;Africa South of the Sahara;AIDS prevention;arm;Biological;budget impact;Caring;Characteristics;Child;Client;Clinical;Collaborations;condoms;Contact Tracing;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;Counseling;Country;Data;Decision Trees;Diagnosis;digital;disability-adjusted life years;E-learning;effectiveness outcome;Emergency Situation;Epidemic;epidemic response;evidence base;Feedback;field study;Goals;Guidelines;Health;Health care facility;health organization;HIV;HIV Seronegativity;HIV Seropositivity;human centered design;Human immunodeficiency virus test;Hybrids;implementation outcomes;implementation research;implementation science;implementation strategy;implementation trial;improved;incremental cost;indexing;innovation;Inservice Training;insight;Institution;Intervention;Knowledge;Lead;Learning;Link;low and middle-income countries;Malawi;markov model;Methods;Modality;Modeling;Outcome;Patient Recruitments;Patients;Persons;pilot test;Play;Policies;Population;Prevention;primary outcome;Principal Investigator;Problem Solving;Procedures;Process;process improvement;programs;prospective;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Research;Research Design;Research Methodology;Role;secondary outcome;service uptake;Services;Sexual Partners;skills;social cognitive theory;Structure;Tablets;technology intervention;Testing;theories;Thinking;tool;Training;Viral;Work;World Health Organization

PROJECT_TITLE: Enhancing HIV assisted contact tracing in Malawi through blended learning: An Implementation Science Study

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Human Genome;Microbiome;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative In recent years it has become increasingly evident that the gut microbiome, the resident population of bacteria in the intestines, plays a key role in health and homeostasis throughout the body including the brain. Our laboratory has found that changes in the gut microbiome can alter the development of drug craving in animal models of relapse and affect how genes are expressed in the brain. These studies will identify how specific manipulations of the microbiome and its molecular byproducts affect brain and behavior, and will provide strategies for targeting the gut microbiome to reduce substance use disorders.

PI_NAMEs: KIRALY, DREW  (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: Abstinence;Acute;Affect;Animal Model;Animals;Antibiotics;Automobile Driving;Bacteria;Behavior;Behavioral;behavioral study;Brain;brain shape;Chromatin Structure;Cocaine;cocaine seeking;cocaine use;Cocaine use disorder;Complex;Corpus striatum structure;cost;Coupled;Development;Disease;drug craving;drug development;drug relapse;drug seeking behavior;Epigenetic Process;Family;FDA approved;Foundations;Gene Expression;gene network;Genes;Genetic Transcription;genome-wide;Grant;gut microbiome;gut-brain axis;Health;Homeostasis;Individual;insight;Intestines;Laboratories;loved ones;microbiome;microbiome analysis;microbiome composition;Modeling;Molecular;Molecular Analysis;Morbidity - disease rate;mortality;Neurobiology;Pathologic;Patients;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Phase;Play;Population;prevent;psychostimulant;Publishing;reconstitution;reduced substance use;Relapse;Research;Rewards;Role;small molecule;Societies;Specificity;stimulant use;stimulant use disorder;substance use;Substance Use Disorder;Synaptic plasticity;System;transcriptome sequencing;Translational Research;Work

PROJECT_TITLE: Targeting gut brain-signaling to reduce cocaine seeking behaviors

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Microbiome

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Mucins are a protein found in natural saliva that provide lubrication, create a protective shield against harmful acids, and play a role in maintaining the balance of the oral microbiome. This project aims to produce artificial mucins that emulate the physicochemical properties and functions of their natural counterparts found in human saliva, which can offer relief to patients afflicted with dry mouth disease. The materials will be optimized to prevent acid erosion of tooth enamel and promote beneficial microbial colonization to promote healthy oral environment.

PI_NAMEs: GODULA, KAMIL  (contact);RUHL, STEFAN HANS-KLAUS

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: 3-Dimensional;Acids;Adhesions;Adsorption;Affect;analog;Animal Model;Area;Artificial Saliva;Bacteria;Biological;Biological Models;chemical group;chemical property;chemical synthesis;commensal bacteria;crosslink;Custom;Deglutition;demineralization;density;Dental Enamel;design;dietary;Dryness;Engineering;Ensure;Environment;Equilibrium;Eye;Feeling;Food;Formulation;fungus;Future;Gel;glycomimetics;glycosylation;Goals;Growth;Human;Hydroxyapatites;improved;Individual;Inflammation;insight;Knowledge;Length;Liquid substance;Lubrication;Marketing;Mastication;Microbe;microbial;microbial colonization;mimetics;Molecular Weight;Mouth Diseases;MUC5B gene;Mucins;mucosal site;Mucous Membrane;Nature;Nose;Oral;Oral cavity;oral microbial community;oral microbiome;Oral mucous membrane structure;Outcome;pathogen;Patients;Pattern;Peptides;Physiological;Play;Polysaccharides;prevent;Property;Protein Glycosylation;Proteins;prototype;Research;Research Personnel;Risk;Role;Saliva;saliva function;Salivary;salivary mucins;Side;stem;Structure;Test Result;Testing;Therapeutic;Time;Tissues;Tooth Demineralization;Tooth Erosion;Tooth structure;Vagina;Vertebral column;Viscosity;Vision;Xerostomia

PROJECT_TITLE: Engineering Mucin Analogues to Benefit the Mouth Environment


ADMINISTERING_IC: AI

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Burden of Illness;Cancer;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Title: Barriers and facilitators of cancer care and financial burden of cancer care in Kinshasa, the Democratic Republic of the Congo PROJECT NARRATIVE Growing cancer morbidity and mortality is a major public health problem in the Democratic Republic of Congo, yet there is lack of data on barriers to cancer care and its cost for cancer patients. This mixed- method study will identify factors associated with access to and adherence to cancer care and the economic burden of care for patients living with and without HIV. Title: Leveraging Existing Infrastructures and Expertise to Enhance Cancer Control in sub-Saharan Africa PROJECT NARRATIVE Sub-Saharan Africa faces a critical lack of reliable cancer data, despite a concerning shift in cancer profiles mirroring trends observed in high-income nations. This supplement seeks to address this significant gap by establishing cancer registries in the Democratic Republic of Congo, Burundi, and Cameroon. These registries will provide governments with essential data, crucial for informed decision-making in cancer control. Additionally, they will facilitate the tracking of adverse clinical outcomes in people living with HIV, a challenge with current data limitations.

PI_NAMEs: ANASTOS, KATHRYN M. (contact);NASH, DENIS ;YOTEBIENG, MARCEL

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adoption;Affect;Africa South of the Sahara;anti-cancer research;Area;Assessment tool;burden of illness;Burundi;Cameroon;Cancer Burden;cancer care;Cancer Center;Cancer Control;cancer diagnosis;Cancer Patient;cancer registrars;cancer statistics;cancer therapy;care burden;care outcomes;Caring;Categories;Central Africa;Cervix Carcinoma;Cessation of life;Chemotherapy and/or radiation;Classification;Clinic;Clinical;Code;cognitive interview;Collaborations;Collection;comorbidity;Comprehensive Cancer Center;Continuity of Patient Care;cost;Cost Analysis;Country;Data;data registry;Data Storage and Retrieval;Databases;Decision Making;Democratic Republic of the Congo;design;Development;Diagnosis;Disease;Economic Burden;Economics;Educational Status;Electronics;Ensure;Epidemic;Epidemiology;epidemiology study;Equipment;Equity;Ethics;experience;Face;fighting;Financial cost;Financial Hardship;Fostering;Foundations;Funding;Future;Government;Health;Health Services;Health Services Accessibility;HIV;HIV Infections;Hospitals;Human Papilloma Virus-Related Malignant Neoplasm;Immunosuppression;improved;Incidence;Income;Individual;Inequity;infection burden;infection related cancer;Infrastructure;International;International Classification of Diseases;Interview;Kaposi Sarcoma;Knowledge;Laboratories;Left;Life Style;low and middle-income countries;Low income;low income country;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medical Records;member;Methods;Monitor;Morbidity - disease rate;mortality;National Cancer Program;neoplasm registry;Non-Hodgkin's Lymphoma;Oncology;operation;Outcome;Palliative Care;parent grant;Participant;Pathology;Patient Care;Patients;Pattern;Persons;Population;population based;Poverty;premature;Prevention;Procedures;Prognosis;programs;Protocols documentation;Public Health;Publications;Quality of life;Quality of Life Assessment;Questionnaires;Radiation therapy;Recommendation;Registries;Reporting;Research;Research Activity;Research Infrastructure;Resource-limited setting;response;Rest;Risk;Rwanda;scale up;screening;Secure;Services;socioeconomics;Software Design;Source;Standardization;Surveillance Program;Surveys;Survival Rate;System;Testing;tool;Training;Training Programs;Transportation;trend;tumor;user friendly software;Vulnerable Populations;western diet;World Health Organization

PROJECT_TITLE: "Enhancing Cancer Research in Central Africa IeDEA"


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Genetic Testing;Genetics;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: MEDELLIN

ORG_COUNTRY: COLOMBIA

ORG_FIPS: CO

ORG_NAME: UNIVERSITY OF ANTIOQUIA

PHR: PROJECT NARRATIVE The principal aim of this administrative supplement is to complete the analysis by SIMOA biofluid markers and compare with lipidome signature in a transversal case-control study of Alzheimer's disease. It will allow to successfully validate and broaden the understanding of early biomarkers in individuals with Alzheimer's disease (AD), focusing on those carrying genetic mutations with high penetrance and susceptibility gene variants and the common pattern with sporadic cases, for future clinical research studies about early detection, pronostic, diagnosis, prevention and treatment of AD and other neurodegenerative diseases at the LatinAmerican region.

PI_NAMEs: CARDONA-GÓMEZ, GLORIA PATRICIA (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: 8 year old;Administrative Supplement;Age;Alzheimer disease detection;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid;Applications Grants;Area;Biological Markers;Blood;Blood Tests;Case/Control Studies;Categories;clinical practice;Clinical Research;Clinical stratification;Clinical Trials;Collaborations;Colombia;Colombian;cost effective;Detection;detection sensitivity;Development;Diagnosis;Diagnostic;diagnostic biomarker;DNA Sequence Alteration;early detection biomarkers;Early Diagnosis;Equipment;Future;Genes;Genetic;genetic variant;Genotype;Healthcare;in vivo;Individual;Infrastructure;Latin American;lipidome;Lipids;Liquid substance;Measurement;Memory Loss;men;Methods;Nerve Degeneration;Neurodegenerative Disorders;Neurosciences;noninvasive diagnosis;Pathology;Pattern;Penetrance;Plasma;Population;Prevention;Prevention program;Primary Prevention;Productivity;prognostic;Prognostic Marker;Protein Isoforms;Proteins;Recording of previous events;Reproducibility;Research;Research Personnel;Research Project Grants;research study;Rest;Serum;sex;Site;Spain;Specificity;Standardization;study population;Susceptibility Gene;tau Proteins;Technology;Time;Training;treatment program;Universities;Variant;Woman

PROJECT_TITLE: IMPLEMENTATION OF BIOFLUID MARKERS FOR EARLY DETECTION OF ALZHEIMER'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES IN COLOMBIA


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: BRAIN GLUCOSE DEFICIENCY: MECHANISMS AND MODULATION. PUBLIC HEALTH RELEVANCE. Pathogenic mutations of the brain glucose transporter type I lead to glucose transporter deficiency syndrome (G1D), which is most often associated with medication-refractory epilepsy and movement dysfunction. At present, G1D is only alleviated by interventions such as the ketogenic diet, which can be poorly tolerated and afford only an incomplete restoration of neural function. A better understanding of G1D fulfills the NIH mission by uncovering new fundamental aspects of brain function while facilitating the development of new therapies aimed to restore brain metabolism and excitability.

PI_NAMEs: COGAN, STUART F;PANCRAZIO, JOSEPH J.;PASCUAL, JUAN M. (contact);SUN, RAMON C.

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Area;Benchmarking;beta-Hydroxybutyrate;Biochemical;Biological;Biological Models;Blood;blood fractionation;Blood Glucose;Brain;brain endothelial cell;Brain imaging;brain metabolism;Categories;Cells;Citric Acid Cycle;Clinical;clinical investigation;Clinical Trials;Clinical Trials Design;Cognition;Cognitive;comparative;Data;data sharing;Dementia;Deoxyglucose;Development;Diagnostic;Disease;Electrocorticogram;Electroencephalography;Epilepsy;Equilibrium;Erythrocytes;Evaluation;Exhibits;experimental study;Failure;Florida;Foundations;Frequencies;Functional disorder;gamma-Aminobutyric Acid;Generations;Genetic Models;Glucose;glucose metabolism;glucose transport;Glucose Transporter;Glutamates;Glycogen;Glycoproteins;Health;Human;In Vitro;in vivo;indexing;inhibitory neuron;Inhibitory Synapse;Institution;Intervention;Intractable Epilepsy;ketogenic diet;Ketone Bodies;Laboratories;Legal patent;Locomotion;Magnetic Resonance Imaging;Mass Spectrum Analysis;Measurement;Measures;Metabolic;Metabolic Brain Diseases;metabolic depression;Metabolic Pathway;Metabolism;method development;Methodology;Methods;Mission;Molecular;Motor;mouse model;Movement;multidisciplinary;Mus;Mutation;Nervous System Disorder;neural;neural circuit;Neuronal Dysfunction;Neurons;neurophysiology;Neurophysiology - biologic function;Neurotransmitters;novel;novel therapeutics;Nuclear Magnetic Resonance;Outcome;oxidation;Pathogenicity;Patient Care;Persons;Pharmaceutical Preparations;Play;Polysaccharides;Positron-Emission Tomography;public health relevance;Resources;Rest;restoration;Schizophrenia;Seizures;Severities;Severity of illness;Slice;Structure;synaptic failure;Syndrome;Testing;Therapeutic;therapeutic development;Translations;treadmill;United States National Institutes of Health;Work

PROJECT_TITLE: Brain glucose deficiency: mechanisms and modulation


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Depression;Drug Abuse (NIDA only);Genetics;Human Genome;Major Depressive Disorder;Mental Health;Mental Illness;Natural Products;Prevention;Schizophrenia;Serious Mental Illness;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Administrative Supplement to Genetic Basis of Cannabis Use Disorder and Cannabinoid Response in Humans Cannabis use (CanUD) and major depressive disorder (MDD) frequently co-occur and have negative consequences including lost productivity, functional impairment, and suicide risk. We propose a carefully- designed training plan that incorporates translational research to study the genetic underpinnings of CanUD and MDD and learn how genetic risk for MDD may predict response to laboratory administration of cannabis, cannabis derivatives, and CanUD treatments.

PI_NAMEs: D'SOUZA, DEEPAK CYRIL (contact);GELERNTER, JOEL

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Acute;addiction;Administrative Supplement;Affect;African;African ancestry;Alcoholism;American;Anhedonia;Anxiety;anxiety symptoms;Applications Grants;Attention;Behavioral;Biological;Cannabidiol;Cannabinoids;Cannabis;cannabis administration;Clinical;Clinical Trials;cohort;Complement;Data Pooling;Data Set;Depressed mood;depressive symptoms;design;Development;disorder risk;Double-Blind Method;Drug Addiction;East Asian;Environmental Risk Factor;Etiology;European;experience;FAAH inhibitor;Functional impairment;Funding;Genetic;genetic analysis;Genetic Risk;Genetic study;genetic variant;Genetic Variation;Genets;Genome;genome wide association study;genome-wide;Genomics;Genotype;Grant;Hallucinations;Human;human subject;Impairment;Individual;individual response;Infusion procedures;interest;Investigation;Laboratories;Laboratory Study;Latino;Learning;Link;Linkage Disequilibrium;London;Long-Term Effects;Major Depressive Disorder;marijuana legalization;marijuana use;marijuana use disorder;Measures;Medical;Memory;Mendelian randomization;Mental Depression;Mental disorders;Meta-Analysis;Methods;modifiable risk;Mood Disorders;Motivation;Outcome;painful neuropathy;Paranoia;parent grant;Persons;Pharmacology;Phenotype;Placebo Control;pleiotropism;polygenic risk score;Population;predicting response;Prevalence;Productivity;psychiatric symptom;Psychiatry;Publishing;Recreation;recruit;Reporting;Research;response;Rewards;Risk;Risk Factors;Role;Safety;Sampling;Schizophrenia;Severities;statistics;Structure;suicidal risk;Symptoms;Testing;Tetrahydrocannabinol;Training;trait;translation to humans;Translational Research;translational research program;United States;Veterans;Work

PROJECT_TITLE: Genetic Basis of the Risk and Consequences of Cannabis Exposure in Humans

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Hypertension;Prevention

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: High blood pressure is the most prevalent modifiable risk factor for dementia and cardiovascular disease among older adults in the United States; however, clinic-based blood pressure measurement is inaccessible to many older adults, especially in the COVID-19 era, often delaying hypertension diagnosis and treatment. While home- based blood pressure measures show promise for overcoming access barriers and promoting more timely treatment, there is a dearth of evidence informing the clinical interpretation of these measurements inolder adults in the United States, a population characterized by high blood pressure variability and discordance from clinic- based blood pressure. Our proposal will perform home blood pressure monitoring and 24-hour ambulatory blood pressure monitoring assessments in over 2,100 community-dwelling adults, aged 80-100 years, establishing the measurement performance, prognostic utility (for dementia and cardiovascular disease), and clinical interpretation of home-based blood pressure measurements in this vulnerable population in the United States.

PI_NAMEs: JURASCHEK, STEPHEN P (contact)

PROGRAM_OFFICER_NAME: REIS, JARED P

PROJECT_TERMS: Address;Adoption;Adult;Affect;Age;Age Years;aged;Aged, 80 and over;aggressive therapy;aging population;Ambulatory Blood Pressure Monitoring;American;Atherosclerosis Risk in Communities;Biosensor;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure intervention;Blood Pressure Monitors;blood pressure variability;Cardiovascular Diseases;Caring;Cessation of life;Clinic;Clinic Visits;Clinical;clinical practice;cohort;Cohort Studies;Collection;Communities;Coronavirus Infections;COVID-19;COVID-19 pandemic;current pandemic;Data;Dementia;dementia risk;design;Devices;Diagnosis;digital monitoring;Elderly;Event;Foundations;Frequencies;Funding;Goals;Health;Home;Home Blood Pressure Monitoring;Hour;human old age (65+);Hypertension;Impaired cognition;Improve Access;improved;innovative technologies;Intervention Trial;Investments;Joints;Knowledge;Machine Learning;Measurement;Measures;Modeling;modifiable risk;Morbidity - disease rate;National Heart, Lung, and Blood Institute;Neurocognitive;older adult;Outcome;outcome prediction;Participant;Performance;Population;Population Heterogeneity;Practice Guidelines;Predisposition;prevent;prognostic;prognostic performance;prognostic value;Prospective Studies;Protocols documentation;racial diversity;Research;Research Personnel;Risk;Risk Factors;risk prediction;risk prediction model;Role;screening;tool;Translations;Transportation;transportation access;trend;United States;virtual;Visit;Vulnerable Populations

PROJECT_TITLE: Prognostic Implications of Home-Based Blood Pressure Monitoring in Older Adults

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: GRAND FORKS

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

ORG_STATE: ND

PI_NAMEs: SCHWARTZ, GARY G (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-3 (CD)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Lung;Rare Diseases;Scleroderma

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative NIAMS Diversity Supplement 2024-2026 The Molecular Basis of Altered Natural Kill Cells in Systemic Sclerosis-associated Interstitial Lung Disease Scleroderma is a devastating autoimmune disease with interstitial lung disease, a leading cause of death in patients and for which limited, effective therapies are available. This project will study natural killer (NK) cells, an immune cell that may be contributing to scleroderma associated- interstitial lung disease (SSc-ILD). By studying how genes of interest from NK cells turn on in scleroderma lung tissue compared to healthy control lung, we will gain further understanding about how NK cells cause lung damage and scarring in scleroderma as well as discover potential molecules to target for new treatment in SSc-ILD.

PI_NAMEs: LAFYATIS, ROBERT A. (contact)

PROGRAM_OFFICER_NAME: GARCIA-CAZARIN, MARY

PROJECT_TERMS: Amphiregulin;AREG gene;Autoimmune Diseases;Blood;Cause of Death;cell killing;Cells;Chromatin;Computer Analysis;cytokine;cytotoxic;effective therapy;experimental study;fibrotic lung;Genes;Genome;Granzyme;Immune;In Vitro;interest;Interferon Type II;Interstitial Lung Diseases;Lung;Lung Diseases;lung injury;Molecular;multiple omics;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural Killer Cells;NK Cell Activation;Nuclear RNA;Pathogenicity;Pathway interactions;Patients;Play;Population;Process;Role;Scleroderma;simulation;single cell ATAC-seq;single cell technology;Structure of parenchyma of lung;Systemic Scleroderma;Transcription Alteration;transcription factor;transcriptome sequencing;Up-Regulation

PROJECT_TITLE: Molecular Basis for Altered Natural Killer Cells in Systemic Sclerosis associated-Interstitial Lung Disease


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE The CHAMPS study seeks to address a critical gap in cancer care delivery for people living with HIV/AIDS (PLWH) in Botswana, a country facing significant burdens of both cancer and HIV/AIDS. By investigating barriers and facilitators in the cancer care cascade and assessing the acceptability and feasibility of peer support intervention using expert clients, this research aims to improve access to cancer care for PLWH, ultimately reducing morbidity and mortality in this population. The findings will inform evidence-based interventions and policies, contributing to improved health outcomes and quality of life for PLWH co-diagnosed with cancer in Botswana and similar resource-limited settings.

PI_NAMEs: CHARURAT, MANHATTAN E (contact);HIMELHOCH, SETH S;MBONGWE, BONTLE

PROGRAM_OFFICER_NAME: ALARO, JAMES R

PROJECT_TERMS: acceptability and feasibility;Address;Africa;anti-cancer research;Applications Grants;Botswana;Cancer Burden;cancer care;care delivery;career development;career networking;Caring;Centers for Disease Control and Prevention (U.S.);Client;Clinical;Communicable Diseases;Comprehensive Cancer Center;Country;design;Development;Diagnosis;Effectiveness;epidemiology study;Evidence based intervention;experience;Grant;Health;Health Personnel;HIV;HIV/AIDS;implementation science;Improve Access;improved;Institution;interest;Intervention;Letters;low and middle-income countries;Malignant Neoplasms;Maryland;medical schools;Mentors;Mentorship;Methods;Mission;Monitor;Morbidity - disease rate;mortality;Oncology;Outcome;peer;peer support;Persons;Policies;Population;Public Health;Publications;Qualitative Research;Quality of life;randomized trial;Research;Research Methodology;Research Personnel;Resource-limited setting;Resources;response;skills;Techniques;Training;Universities;Writing

PROJECT_TITLE: The Botswana Cancer-HIV Care Assistance and Monitoring using Peers (CHAMPS)


FUNDING_MECHANISM: OTHERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Primary Health Care;Social Determinants of Health;Women's Health Research

ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

PI_NAMEs: BAYTOP, CHANZA  (contact)

PROGRAM_OFFICER_NAME: STONEY, CATHERINE

PROJECT_TERMS: Address;Affect;antenatal;Area;Behavior;Behavioral;Biological;Black race;Cardiomyopathies;Cardiovascular system;caregiving;Caring;Cause of Death;Clinical;Communities;community engagement;community organizations;community partnership;Complex;Conceptions;Coping Behavior;Development;Discrimination;Eclampsia;Embolism;Ensure;Environmental Risk Factor;Ethnic Origin;evidence base;experience;Exposure to;Family;Funding Opportunities;Future;Gestational Diabetes;Goals;Health;Health Disparities Research;Health Priorities;Health Sciences;Health Status;Healthcare Systems;Hemorrhage;Hypertension;implicit bias;improved;Infection;Infrastructure;insight;intrapartum;Life Cycle Stages;life span;Maternal Health;maternal morbidity;Maternal Mortality;Mental Health;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Needs Assessment;Not Hispanic or Latino;Obesity;opioid use;Outcome;Play;Population Heterogeneity;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Primary Care;programs;protective factors;Psyche structure;psychologic;Race;Research;Risk Factors;Role;Scientist;Sleep Disorders;Smoking;social;social determinants;Strategic Planning;Strategic vision;Stress;Support Groups;Testing;theories;trend;United States;United States National Institutes of Health;Woman;Women's Health;Work

PROJECT_TITLE: NHLBI Community Engagement Technical Assistance Center (CETAC)

SUFFIX: SD


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The Enhancing Real-World Data with Measures of Social Determinants of Health project will facilitate the use of real-world data (RWD) across NCI Persistent Poverty Initiative Centers, encouraging collaborative initiatives that harness RWD to understand and address structural and social determinants of health that drive cancer inequalities in persistent poverty areas. First, we will create measures of the most commonly used social deprivation indexes, and area-based measures of structural racism, and make these measures publicly available with code and documentation for how they are created. Next, we will use new artificial intelligence approaches to create synthetic versions of SEER-Medicare data, and make this available to researchers at NCI Persistent Poverty Initiative Centers.

PI_NAMEs: BONDY, MELISSA L.;CARVAJAL CARMONA, LUIS GUILLERMO;GRUSKY, DAVID B;HIATT, ROBERT A;REHKOPF, DAVID H (contact)

PROGRAM_OFFICER_NAME: HARDESTY, REBECCA ANNE

PROJECT_TERMS: Address;Area;Artificial Intelligence;Automobile Driving;Cancer Burden;Cancer Etiology;Code;Complex;Data;Data Sources;deprivation;Documentation;Geography;Goals;Incidence;Income;indexing;Inequality;Inequity;Intervention;Link;Malignant Neoplasms;Measures;Medicare;mortality;Population Heterogeneity;Poverty;Poverty Areas;Process;Research;Research Personnel;social;social deprivation;social health determinants;Social Impacts;Source;structural determinants;Structural Racism;synthetic data;timeline;Work

PROJECT_TITLE: The Upstream Center: Income Interventions to Address the Fundamental Causes of Cancer Inequities


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: MADISON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The National Magnetic Resonance Facility at Madison (NMRFAM) research resource provides access to state- of-the-art solution and solid-state NMR technology to the biomedical research community, enabling facility users to leverage the power and diversity of NMR methods to study the structure, dynamics, function and interactions of large and small biomolecules. NMRFAM will continue to provide reliable and timely access to NMR instrumentation with excellent staff support for all phases of the NMR experience, in order to engage actively in experiment design well aligned with user objectives, to obtain the highest quality data possible and to commit to interpreting results to solve highly significant biomedical research problems that are best addressed by NMR.

PI_NAMEs: BUTCHER, SAMUEL E;HENZLER-WILDMAN, KATHERINE ANNE (contact);RIENSTRA, CHAD M

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Address;Administrative Supplement;Adopted;Advisory Committees;Area;Automation;base;Biological;Biomedical Research;Biophysics;Calibration;Capital;Cell Nucleus;Collaborations;Communication;Communities;community engagement;Complex;Computer software;computerized data processing;Consult;Cryoelectron Microscopy;cryogenics;cyber security;Data;Data Analyses;Data Collection;data quality;Data Security;data sharing;Detection;Development;Doctor of Philosophy;Educational process of instructing;Educational workshop;Emerging Technologies;Ensure;experience;Experimental Designs;experimental study;FAIR principles;Goals;Helium;Home;Human Resources;Hybrids;improved;Individual;Infrastructure;Institution;instrument;instrumentation;interest;Isotopes;Knowledge;Ligands;Liquid substance;Magic;Magnetic Resonance;Maintenance;Membrane Proteins;metabolomics;Methods;Mission;Molecular Weight;National Center for Research Resources;National Institute of General Medical Sciences;Natural Products;next generation;NMR Spectroscopy;Nucleic Acids;operation;outreach;Performance;Pharmaceutical Preparations;Phase;Physiologic pulse;Procedures;programs;protein structure;Proteins;Protocols documentation;Quality Control;R24;Recovery;recruit;Recycling;repaired;Reproducibility;Research Support;Resources;Sampling;Schedule;Scientist;screening;Services;Site;solid state nuclear magnetic resonance;Standardization;structural biology;Structure;Surveys;System;Technology;Testing;Time;tool;Training;training opportunity;Tube;web server;Work;Writing

PROJECT_TITLE: Administrative Supplement: NMR User Program at NMRFAM


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cocaine;Genetics;Human Genome;Mental Health;Neurosciences;Stimulant Use and Misuse;Substance Misuse;Women's Health Research

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Individuals suffering from substance use disorders are susceptible to relapse when presented with  contextual cues, suggesting that contextual memories associated with drugs of abuse impede abstinence  success. Developing effective treatments to assist with maintaining abstinence is a significant challenge,  complicated by unique, sex-dependent responses to drugs of abuse in women compared to men. Thus,  understanding sex differences in neural circuitry driving contextual drug memories is critical to the

PI_NAMEs: KOHTZ, AMY  (contact)

PROJECT_TERMS: Abstinence;addiction;Animal Model;Area;Automobile Driving;Behavior;Behavioral;Behavioral Model;Biological;Clinical Research;Cocaine;cocaine seeking;craving;Cues;Data;Dependence;designer receptors exclusively activated by designer drugs;Development;Disease;Dorsal;drug abstinence;Drug Addiction;drug of abuse;drug seeking behavior;drug standard;Drug usage;effective therapy;Extinction;Female;functional genomics;Genetic;Health;Hippocampus;Individual;Intervention;Maintenance Therapy;male;Memory;men;Methods;Molecular;Molecular Profiling;neural circuit;novel;Pharmaceutical Preparations;Predisposition;psychologic;Rattus;Relapse;relapse prediction;relapse risk;Reporting;Research;response;sex;Sex Differences;single-cell RNA sequencing;substance abuse treatment;Substance Use Disorder;success;System;Testing;Trademark;transcriptome sequencing;Viral;Woman;women versus men

PROJECT_TITLE: Sex differences in operant cocaine memories


NIH_SPENDING_CATS: Allergic Rhinitis (Hay Fever);Asthma;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Infectious Diseases;Lung;Pediatric;Prevention

PHR: Contact PD/PI: Jackson, Daniel J. PROJECT NARRATIVE Asthma disproportionately affects children in urban communities in the United States and imposes a great personal and health care burden. Despite treatment advances, a significant proportion of patients do not achieve disease control and continue to have high levels of morbidity and currently no intervention has proven to either prevent or cure this disease. By identifying and addressing these unmet needs in this application, we propose to improve current asthma care in urban children, pursue disease modification, and ultimately develop effective strategies to prevent asthma.

PI_NAMEs: GERN, JAMES E.;JACKSON, DANIEL J (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Acetone;adaptive immune response;Address;Administrative Supplement;Affect;Age Years;airborne allergen;Allergic;Allergic rhinitis;Anti-Bacterial Agents;Asthma;Bacterial Infections;Birth;Caring;CD19 gene;Cells;Child;Childhood;Childhood Asthma;Chronic Rhinitis;cohort;Cohort Studies;Collection;comparison group;Complement;COVID-19 pandemic;Custom;Data;Depressed mood;detection assay;differential expression;Disease;disorder control;DNA;DNA Methylation;Down-Regulation;Enrollment;Environmental Exposure;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Experimental Designs;Exposure to;Extrinsic asthma;follow-up;Gene Chips;Gene Expression;gene network;Genes;Genetic;Granzyme;Haemophilus influenzae;healthcare burden;high risk;Hypersensitivity;IgE;IgG2;Immune Response Genes;Immunoglobulin A;Immunoglobulin M;Immunoglobulins;improved;infection risk;Inflammation;Innate Immune Response;Intervention;IRF1 gene;Leadership;Life;liquid chromatography mass spectrometry;Mass Spectrum Analysis;Mediating;Modification;Moraxella catarrhalis;Morbidity - disease rate;Mucosal Immune Responses;Mucosal Immunity;Nasal Epithelium;Nose;novel;pathogenic bacteria;Patients;Phenotype;Pilot Projects;Predisposition;prevent;protein expression;Proteins;Proteomics;RANTES;Recording of previous events;Reporting;respiratory;Respiratory Mucosa;response;Rhinitis;RNA;Sampling;Self Care;Sinusitis;Specimen;STAT1 gene;Symptoms;Testing;Time;United States;urban children;Urban Community;urban setting;Viral;Viral Genes;Virus Diseases

PROJECT_TITLE: Childhood Asthma in Urban Settings Leadership Center Administrative Supplement for URECA Yr4


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

ORG_CITY: SAN DIEGO

ORG_NAME: IRISYS, INC.

PI_NAMEs: GIANNINI, ROBERT  (contact)

PROJECT_TERMS: analytical method;Businesses;Contracts;Development;Dosage Forms;Formulation;Guidelines;manufacture;Oral;Pharmaceutical Preparations;Phase I Clinical Trials;Solid;Tablets;Validation

PROJECT_TITLE: SOCIETAL IS A SMALL BUSINESS CONCERN FOR DOSAGE FORM DEVELOPMENT, MANUFACTURE, AND STABILITY STUDIES OF NCGC72


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_NAME: FISHER BIOSERVICES, INC.

PI_NAMEs: MANDACI, OGUZ  (contact)

PROJECT_TERMS: Adolescent;Adolescent Medicine Trials Network;antiretroviral therapy;Bar Codes;Biological Specimen Banks;Brazil;Child;Childhood;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;Cohort Studies;Collaborations;Communicable Diseases;Contractor;Contracts;Data;Data Coordinating Center;data management;Dose;Drug Kinetics;Electronic Mail;Equipment and supply inventories;Exercise;Foundations;frontier;Funding;Guidelines;HIV;HIV Infections;HIV therapy;HIV-exposed uninfected infant;HIV/AIDS;Infant;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Intervention;Label;Laboratories;Management Information Systems;Monitor;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;Notification;operation;pediatric human immunodeficiency virus;Performance;perinatal HIV;Policies;Population;pregnant;Pregnant Women;preventive intervention;Procedures;Process;programs;Protocols documentation;Public Health Schools;repository;Research;Research Activity;Safety;sample collection;Sampling;Science;Services;Shipping;Site;Specimen;Symptoms;System;Technology;Teleconferences;Telephone;Toxic effect;United States;United States National Institutes of Health;Update;Vertical Disease Transmission;Woman;Youth

PROJECT_TITLE: REPOSITORY SERVICES FOR THE MATERNAL AND PEDIATRIC INFECTIOUS DISEASE BRANCH (MPIDB) SPECIMENS


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PI_NAMEs: FOUTS, TIM  (contact)

PROJECT_TERMS: Adjuvant;Bacterial Drug Resistance;Biological Products;Clinical Research;Communicable Diseases;Contracts;Cyclic GMP;Development;Development Plans;fungus;manufacture;novel vaccines;pathogen;Phase;Process;product development;Services;System;United States Food and Drug Administration;vaccine delivery;vaccine development;Vaccines

PROJECT_TITLE: Task V31: Process Development for Panfungal Vaccine


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: RICHMOND

ORG_NAME: VA VETERANS ADMINISTRATION HOSPITAL

ORG_STATE: VA

PHR: Project Narrative: Multiple sclerosis is a devastating disease that inflicts sensory, motor and cognitive deficits on thousands of US veterans. Currently, there is no cure and the available therapies have variable results. MS is classically described as a demyelinating disease; However, more recent work has demonstrated that much of the irre- versible functional loss associated with this disease results from pathology of the nerve cell. Although nerve cell damage is now being investigated, it is being studied strictly as a consequence of chronic demyelination. Our previous work showed that the nerve cell is a primary target of attack and implicated the resident brain immune cells known as microglia as the facilitator of the attack. Here, we will investigate a novel factor that is may be critical for this attack and determine if this factor can be a therapeutic target for disease amelioration.

PI_NAMEs: DUPREE, JEFFREY L. (contact)

PROJECT_TERMS: Ablation;Actins;Action Potentials;Anti-Inflammatory Agents;Attenuated;Axon;axon injury;Brain;Cell Adhesion Molecules;cell injury;cell type;Cells;Chronic;chronic demyelination;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive deficits;Cre-LoxP;Cues;cytokine;Data;Demyelinating Diseases;Demyelinations;density;disabling disease;Disease;effective therapy;Ensure;Event;Experimental Autoimmune Encephalomyelitis;Experimental Models;Factor V;functional loss;Goals;gray matter;Health system;Immune;Impaired cognition;In Vitro;in vivo;Inflammatory;Injury;Knock-out;LoxP-flanked allele;Mediating;Microglia;migration;Modeling;Morphology;Motor;motor deficit;mouse model;Multiple Sclerosis;Mus;Myelin;neurofascin;Neurologic Dysfunctions;Neurons;novel;Pathologic;Pathology;Play;preservation;Process;Production;Protein Isoforms;repaired;response;restoration;Role;Sensory;Severity of illness;Site;Structure;Swelling;System;Testing;therapeutic target;Veterans;white matter;Work

PROJECT_TITLE: Attenuating microglial-dependent axonal pathology in EAE


ORG_CITY: GAINESVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: FL

PHR: This study is intended to correct an important systemic deficit in the care of chronic kidney disease (CKD), VHA’s fourth most common healthcare condition with high mortality and healthcare burden. Currently, many Veterans with CKD have poor awareness of their condition. This leads to suboptimal care. We anticipate that our proposed comprehensive pre-end stage renal disease (ESRD) education (CPE) will enhance Veterans’ CKD knowledge and their confidence in making an informed selection of an appropriate dialysis modality, and lead to an increase in the use of home dialysis (HoD) – an evidence-based, yet underutilized dialysis modality. Further, this study will allow us to examine whether such Veteran-informed dialysis choice can improve Veteran and health services outcomes. If successful, this study may deliver a ready to roll-out strategy to meet the CKD care needs of the Veterans and reduce VHA healthcare costs.

PI_NAMEs: JIA, HUANGUANG ;SHUKLA, ASHUTOSH M (contact)

PROJECT_TERMS: 18 year old;Address;Advocate;Arkansas;Awareness;Blood Vessels;Canada;care costs;Caring;Chronic Care;Chronic Kidney Failure;Clinical;Clinical Services;cohort;Consent;cost;Cost of Illness;Data;Decision Making;Diagnosis;Dialysis procedure;Disease;Disease Outcome;Education;Educational Models;Effectiveness;empowerment;End stage renal failure;Enrollment;Europe;European;evidence base;Fees;Florida;Glomerular Filtration Rate;Goals;Health Care Costs;Health Promotion;health related quality of life;health service use;Health Services;Health Services Accessibility;Health system;Healthcare;healthcare burden;Healthcare Systems;Home;Improve Access;improved;Inpatients;Intervention;Interview;Kidney;Kidney Diseases;Knowledge;Learning;Logistic Regressions;Managed Care;meetings;Methods;Modality;Modeling;mortality;Outcome;Outpatients;Outsourcing;Patient Education;patient oriented;Patient Outcomes Assessments;Patient-Centered Care;Patients;Persons;Pilot Projects;pilot test;Policy Maker;post intervention;preference;Preparation;primary outcome;programs;prospective;Protocols documentation;Random Allocation;Regression Analysis;Reporting;Research Priority;Risk Adjustment;rural area;satisfaction;secondary outcome;Services;Societies;Structure;System;Telemedicine;Time;treatment as usual;Universities;urban area;Veterans;Visit

PROJECT_TITLE: A Patient-centered, System-based Approach to Improve Informed Dialysis Choice and Outcomes in Veterans with CKD

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: Narrative The focus of this Collaborative MERIT Application is to better understand how environmental toxins veterans were exposed to during the Gulf War (GW) may have uniquely sensitized the neuroimmune system to subsequent insults, rendering them at risk for eliciting amplified or persistent neuroinflammatory or immune responses when subjected to psychological stressors. Through this project, we plan to execute experiments that will investigate if GW toxins amplify immune responses to psychological stressors, if this process is a function of transcriptional priming of the NLRP3 inflammasome, and if we can selectively target the activation of the NLRP3 inflammasome to attenuate neuroinflammatory responses. By investigating these mechanisms, we hope to identify novel therapeutic methods that may provide veterans of the Gulf War both interventional and preventative options to help manage GWVI symptoms.

PI_NAMEs: PASINETTI, GIULIO MARIA (contact)

PROJECT_TERMS: Animal Model;arm;Attenuated;Autoimmune Diseases;Award;Biological Availability;Biological Models;Brain;Brain Pathology;Bromine;Chemistry;Clinical;Collaborations;Complex;cytokine;design;Diagnosis;Disease;Education;Etiology;Event;Experimental Models;experimental study;Exposure to;Fatigue;fluorophosphate;Future;Genetic Polymorphism;Genetic Transcription;Genetic Variation;Goals;Gulf War;Gulf War veteran;gut dysbiosis;Health Promotion;Immune;immune activation;immune cell infiltrate;Immune response;Immune system;Immunity;Immunologic Tests;Immunologics;Immunotherapeutic agent;Impaired cognition;improved;Individual;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Innate Immune Response;innovation;innovative technologies;insight;Interdisciplinary Study;interest;Interleukin-1 beta;Intervention;Joints;Knock-out;Link;Mediating;Medical center;Mental Depression;Methods;Microbiology;Microglia;Modeling;Molecular;Mood Disorders;mouse model;mRNA Expression;multidisciplinary;Mus;Neuroimmune system;neuroinflammation;Neurosciences;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Organ failure;Outcome Study;Pain;Pathologic;Pathology;Pathway interactions;Peripheral;Permethrin;Pesticides;pharmacologic;Pharmacology;Phenotype;Plasma;pre-clinical;pre-clinical research;Predisposition;Probiotics;Process;programs;Proteins;Psychological Stress;psychological stressor;Public Health Schools;pyridostigmine;Quality of life;Reaction;Research;Research Personnel;Research Project Grants;response;Risk;Risk Factors;Role;Science;Septic Toxemia;social defeat;Stimulus;Stress;stressor;Symptoms;synergism;Testing;Therapeutic;therapeutic target;tissue degeneration;Toxic Environmental Substances;Toxin;Translating;translational study;Uranium;Vaccination;Vaccines;Veterans;Veterans Health Administration;Vision;Work

PROJECT_TITLE: CMA: Immune/inflammatory priming in exacerbating responses to GWVI stressors: implications for GWVI treatments


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Up to 1 in 5 US children experiences a communication disorder before age 6, causing long-term social, emotional, behavioral, academic, physical health, and mental health risks. Early Intervention improves outcomes; however, children from racial, ethnic, and/or linguistic minority populations, including those living in rural areas and/or poverty, have less access to timely, accurate identification and high-quality communication disorder treatment. Using stakeholder engagement methods and data from over 100,000 children in five states, we will identify key sources of structural racism and discrimination for children with communication disorders in the Early Intervention system and use findings to develop actionable practice and policy recommendations.

PI_NAMEs: CYCYK, LAUREN M.;ZUCKERMAN, KATHARINE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Administrator;Adult;Advocate;Affect;Age;Attitude;autism spectrum disorder;Behavioral;Belief;Big Data;Caring;Characteristics;Child;Child Care;Child health equity;child services;Child Support;Childhood;children of color;Clinical;Color;Communication;Communication impairment;Communities;community-level factor;Complex;Consensus;Criminal Justice;Data;Development;disability;Discrimination;Disparity;early childhood;Early identification;Early Intervention;early satiety;Early treatment;Education;Eligibility Determination;Emotional;Equity;Ethnic Origin;Evaluation;Evidence based intervention;Exclusion;experience;Face;Family;Family Characteristics;Focus Groups;Foundations;Funding;Goals;Health;Health Care Costs;Health Disparities Research;health disparity;health inequalities;Health Services Accessibility;hearing impairment;Home;Human;improved;improved outcome;Individual;Individuals with Disabilities Education Act;inequitable distribution;Information Systems;innovation;Intervention;Interview;Language;Language Disorders;Leadership;Linguistics;Locales;marginalized population;member;Mental Health;Methods;Minority Groups;National Institute on Deafness and Other Communication Disorders;Organizational Policy;Outcome;Parents;Pathologist;Personal Satisfaction;physical conditioning;Policies;policy recommendation;Population;Poverty;Poverty Areas;Primary Care Physician;Process;programs;Provider;provider intervention;Race;Recommendation;Regulation;Reproducibility;Research;Resources;Risk;Rural;rural area;rural poverty;School-Age Population;service intervention;service providers;Services;social;Source;Specialist;Speech;Speech Disorders;stakeholder perspectives;structural determinants;Structural Racism;Structure;Surveys;Symptoms;System;Techniques;US State;Variant

PROJECT_TITLE: Addressing Structural Disparities for Children with Early Communication Disorders (ASCEND)


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: PROJECT NARRATIVE This proposal seeks the establishment of the Puerto Rico Racial & Ethnic Minority Acceleration Consortium for Health Equity (PR-REACH) to support the advancement of Hispanic Puerto Ricans health equity, this is a first step in a research agenda to collaborate with the Food and Drug Administration (FDA) Office of Minority Health and Health Equity (OMHHE) across REACH research projects and activities by first building an administrative research and communication infrastructure; leadership team, three EQUITY research cores (Clinical Trials, Voices and Data), a training and mentoring core, and an advisory team. A pilot study under this consortium will be conducted to advance the understanding of substance use disorder patients’ journey as perspectives, preferences and unmet needs regarding substance use disorder (SUD) treatment with FDA approved medications in PR to be able to improve its outcomes and launch PR-REACH in PR. The PR-REACH will initiate with Hispanics living in Puerto Rico as a model than can inform and guide subsequent extrapolation to Hispanics in the US in collaboration with the FDA.

PI_NAMEs: MARTINEZ GONZALEZ, KAREN G.;SANTIAGO, DARLENE I (contact)

PROGRAM_OFFICER_NAME: LEE, CHRISTINE


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide, and rurality is associated with worse COPD prevalence and outcomes. This application aims to test the uptake, effectiveness, and patient-caregiver-provider experience of a crucial treatment not provided in rural areas: pulmonary rehabilitation. The proposed intervention will provide home-based pulmonary rehabilitation to every patient recruited and will address access to care as SDOH and two aspects of social injustice in COPD: inadequate COPD care and lack of support for rural patients.

PI_NAMEs: BENZO, ROBERTO PABLO (contact)

PROGRAM_OFFICER_NAME: AKUBU-ODERO, MAUREEN KALAMBU

PROJECT_TERMS: actigraphy;Acute;Address;Age;Air Pollution;Anxiety;barrier to care;Caregivers;Caring;Cause of Death;Chronic;Chronic Obstructive Pulmonary Disease;clinical practice;Clinical Trials;Communities;Data;Diabetes Mellitus;Disease Outcome;disparity reduction;Dyspnea;Education;effective intervention;Effectiveness;Emotional;Environmental Exposure;Equitable healthcare;evidence base;experience;formative assessment;Funding;geographic barrier;geographic disparity;Health;health care availability;health care service utilization;Health Personnel;health related quality of life;Health Services Accessibility;Heart failure;Home;Hypertension;implementation barriers;improved;Income;Inequality;insight;Intervention;Intervention Trial;Knowledge;Literature;Loneliness;Lung Diseases;Measures;Mental Depression;Methods;Morbidity - disease rate;mortality;Obesity;Outcome;participant interview;Patient Recruitments;Patients;Perception;personalized approach;Physical activity;Physical Exercise;preference;Prevalence;programs;prospective;Provider;pulmonary rehabilitation;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;Rehabilitation therapy;remote health care;Reporting;Research;respiratory;Risk;Rural;rural America;rural area;Rural Community;rural dwellers;rural patients;Rural Population;rural setting;rurality;Scientific Advances and Accomplishments;sedentary;social;social health determinants;Social isolation;Social support;Testing;testing uptake;Time;treatment as usual;United States;United States National Institutes of Health;uptake;urban area

PROJECT_TITLE: Decreasing Disparity in Lung Disease: Pulmonary Rehabilitation for Rural Patients with COPD

STUDY_SECTION_NAME: Special Emphasis Panel[ZNR1 REV-M (44)]


ORG_CITY: ALBUQUERQUE

ORG_NAME: AMERICANS FOR INDIAN OPPORTUNITY

ORG_STATE: NM

PHR: Project Narrative Three sentences   With a collaborative approach grounded in Indigenous core cultural values, the Indigenous Innovators Collaborative (IIC) team will engage in community-based participatory research study to address the FDA priorities as outlined in FDA OMHHE Health Equity Innovation Award: Racial and Ethnic Minority Acceleration Consortium for Health Equity (REACH) funding opportunity. The IIC seeks to engage American Indian and Alaska Native (AIAN) communities, stakeholders, researchers in an exploration of clinical trials and promote cultural knowledge in understanding clinical trials in Indian Country. One of the fundamental goals of this study is to aid in identifying perceptions of clinical trials and gene therapy within the Native American population.

PI_NAMEs: KIPP, BILLIE ;PARKER, MYRA ELIZABETH;POSTON, STEPHINE  (contact)

PROJECT_TITLE: Racial & Ethnic minority Acceleration Consortium for Health Equity (REACH) Response from Indigenous Innovators Collaborative


ORG_CITY: SOUTH SAN FRANCISCO

ORG_NAME: PERSPECTUM DIAGNOSTICS, INC.

PHR: Project Narrative Primary Sclerosing Cholangitis (PSC), a heterogenous cholestatic condition often leading to multi-focal stricturing due to progressive constriction and blockage of the intrahepatic and/or extrahepatic bile ducts, is an autoimmune liver disease characterized by slow but persistent inflammation and fibrosis surrounding the bile ducts which can result in the development of malignancy in up to 20% of cases. Although there are some pharmacotherapies being used to support PSC management, there are no regulatory approved therapies for the disease which has resulted in PSC having the highest rate of liver transplantation amongst all autoimmune liver diseases. In this project, Perspectum seeks to complete the necessary evidence to qualify the MRCP+ biomarker number of strictures as a monitoring biomarker, used in conjunction with clinical risk factors, by evaluating disease progression in a PSC population.

PI_NAMEs: PANDYA, PRASHANT K (contact)

PROGRAM_OFFICER_NAME: TOMITA, YORK

PROJECT_TITLE: DDT-BMQ-000146 Assessing clinically meaningful change in PSC as determined by quantitative MRCP (MRCP+) measured number of strictures

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CDER-T (19)]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Recovery Support Services;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative This administrative supplement will provide Dr. Felecia Pullen with a half-time fellowship to provide her with the experience, training, mentoring, and networking to enable her to conduct NIH-funded research, while continuing to lead her own recovery community center. By training with Dr. Bettina Hoeppner within the context of this R34, she will expand her professional network, gain applied research skills, and receive mentoring to advance her scientific career.

PI_NAMEs: HOEPPNER, BETTINA B. (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: addiction;Address;Administrative Supplement;Applications Grants;Applied Research;Area;Assessment tool;Black American;Black race;Capital;career;career development;career networking;Clinic;Collaborations;Communities;community engaged research;Data;Death Rate;Decision Making;design;Doctor of Philosophy;effectiveness testing;effectiveness trial;Environment;experience;Fellowship;Funding;General Hospitals;Goals;Grant;Growth;Heart;improved;Inequality;Institutional Racism;interest;Investments;Journals;Lead;Leadership;Learning;Logistics;Manuscripts;Massachusetts;medication for opioid use disorder;meetings;Mentors;Mentorship;Methods;National Institute of Drug Abuse;New York;New York City;Ohio;Outcome;Paper;parent grant;peer;peer recovery;Peer Review;people of color;Persons;Policies;Preparation;Procedures;Process;programs;Publishing;R24;Recovery;recovery community organization;recovery services;Recovery Support;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Role;Science;Scientific Advances and Accomplishments;Services;skills;Social Work;symposium;Testing;Time;Training;Training Activity;Underserved Population;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Research supplement to promote diversity within the context of research involving recovery community centers


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: MANASSAS

ORG_NAME: AMERICAN TYPE CULTURE COLLECTION

PI_NAMEs: COUCH, HEATHER  (contact)

PROJECT_TERMS: Advanced Development;Anti-viral Agents;Basic Science;Biological Assay;Cell Line;Contracts;Development;in vitro testing;Maintenance;pathogenic virus;Production;Venezuelan Equine Encephalitis Virus;Viral;Virus

PROJECT_TITLE: Task B24: Production of Well Characterized Challenge Material (WCCM) of High Priority Viral Pathogens


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Depression;Mental Health;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Pregnancy;Social Determinants of Health;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Intimate partner violence (IPV) includes assault to the head, neck, and face, with approximately 90% of survivors reporting symptoms concordant with persistent post-concussion symptoms, wherein pregnancy is associated with increased intensity and frequency of physical assault. Like stress, drugs, and inflammation, traumatic brain injury (TBI) during pregnancy, from IPV, falls, motor vehicle accidents, can increase the environmental risk for neurodevelopmental disorders in the children. The proposal extends strong proof-of-principle results to explore the outcomes of gravida TBI – TBI during pregnancy – in mice on the neurobehavioral, neurocircuitry, and molecular phenotypes of offspring to better inform science, education, and policy making.

PI_NAMEs: LIFSHITZ, JONATHAN  (contact);QIU, SHENFENG

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Adult Children;Anxiety;anxiety reduction;assault;automobile accident;Behavior;behavioral phenotyping;Birth;Brain;cell cortex;cell type;Cells;Child;Cognition;Data;Databases;depressive symptoms;Development;developmental disease;Diffuse;Education;Electrophysiology (science);Environmental Risk Factor;Face;falls;Female;fetal;Frequencies;Gene Expression;Goals;Head;Hippocampus;immune activation;Immune response;Inflammation;intimate partner violence;Investigation;Laboratory Study;Lasers;Life;Live Birth;male;men;Mental Depression;Molecular;molecular phenotype;Morphology;Mus;Neck;neural circuit;neurobehavioral;neurodevelopment;Neurodevelopmental Disorder;Neurons;neuropsychiatry;offspring;Outcome;Performance;Persons;Pharmaceutical Preparations;Phenotype;physical assault;Physiology;Policy Making;Post-Concussion Syndrome;postnatal;Pregnancy;pregnant;protein expression;Proteins;Race;Reporting;Research;Risk;Scanning;Science;Social Behavior;socioeconomics;Standard Model;Stress;Survivors;Symptoms;Synapses;Testing;transcriptomics;Traumatic Brain Injury;vehicular accident;Weaning;Weight;Western Blotting;Woman;young adult

PROJECT_TITLE: Gravida traumatic brain injury (TBI) impacts neurodevelopment of the offspring

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Cardiovascular;Clinical Research;Genetics;Kidney Disease;Lupus

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: NARRATIVE Up to 60% of African Americans, who are at heightened risk for kidney and cardiovascular disease (CVD), carry at least one Apolipoprotein L1 (APOL1) coding change variant allele. These variants associate with adverse renal and CVD outcomes—particularly in chronic inflammatory disease such as SLE. By leveraging SLE monocyte transcriptional profiles validated by primary cell culture models, this study will test the overall hypothesis that immune activation and resultant increased APOL1 expression synergizes with APOL1 genotype to precipitate human disease.

PI_NAMEs: BLAZER, ASHIRA DESHON (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;African American;African American population;Animal Model;Apolipoproteins;Atherosclerosis;Autoimmune Diseases;Awareness;Binding;Biological Response Modifier Therapy;Biological Response Modifiers;Biology;Blood Vessels;candidate identification;Cardiology;Cardiovascular Diseases;Cardiovascular system;career;career development;Cell Culture Techniques;Cell Death;Chronic;chronic inflammatory disease;Clinical;Code;cohort;collaborative environment;comorbidity;Complex;Computational Technique;cytokine;cytotoxicity;Data;Defect;Disease;Disease Outcome;disease phenotype;End stage renal failure;Endothelial Cells;Exhibits;experience;Foundations;functional genomics;Future;gene environment interaction;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;Genetic Models;Genetic Transcription;genetic variant;Genome;Genotype;genotyped patients;Goals;high risk;HIV;Human;human disease;Hypersensitivity;Hypertension;Immune;immune activation;Immune system;Immunologics;Immunology;immunoregulation;In Vitro;Individual;Inflammation;Inflammation Mediators;Inflammatory;Injury;Injury to Kidney;innovation;Interferons;Kidney;Kidney Diseases;kidney dysfunction;knock-down;Laboratories;Lupus Nephritis;Mediating;Mediator;Mentors;Methods;Mitochondria;mitochondrial dysfunction;Modeling;monocyte;mortality;Necrosis;novel;Organ;Outcome;Pathway interactions;Patients;Penetrance;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;population based;Positioning Attribute;Primary Cell Cultures;promoter;Proteins;Regulation;Regulatory Element;Reproducibility;Research Design;Resources;Respiration;response;Rheumatology;Risk;risk stratification;risk variant;Stimulus;success;Surveys;synergism;Systemic Lupus Erythematosus;Testing;therapeutic evaluation;therapeutic target;tissue injury;Training;trait;transcription factor;transcriptome sequencing;Translating;translational scientist;Variant

PROJECT_TITLE: SLE-AWARE: SLE-- A Window into APOL1 Regulation and Expression

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: No PHR

PI_NAMEs: MAZUMDER, RAJA  (contact);RANZINGER, RENE ;TIEMEYER, MICHAEL

PROGRAM_OFFICER_NAME: KINSINGER, CHRISTOPHER

PROJECT_TITLE: Harmonization of GlyGen glycoconjugate and glycan array data for integration into CFDE


NIH_SPENDING_CATS: Genetics;Hearing Loss;Neurosciences

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE  Filaments made of beta and gamma actin are proteins that provide the shape and stability of structures known as stereocilia within the inner ear. Stereocilia detect vibrations and convert them into electrical signals that the brain eventually comprehends as sound or head movement. This project centers around how a specific gamma actin mutation alters the structure and stability of the stereocilia to understand its associated hearing loss.

PI_NAMEs: VELEZ ORTEGA, ALEJANDRA CATALINA (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Actins;Affect;Antibodies;Apical;Auditory;beta Actin;Brain;Buffers;Calcium;cell motility;cellular microvillus;Cellular Morphology;channel blockers;Confocal Microscopy;crosslink;Cytoskeleton;Data;depolymerization;Development;Exhibits;F-Actin;Filament;gamma Actin;Genes;Genets;Hair;Hair Cells;Head;Head Movements;hearing impairment;Height;Heterozygote;human model;Immunohistochemistry;Impairment;Inner Hair Cells;Kinetics;Labyrinth;Lead;Link;Maintenance;mechanotransduction;Microfilaments;Molecular;Morphology;Motion;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Natural regeneration;Noise;Organelles;Pharmaceutical Preparations;Phenocopy;Phenotype;Play;polymerization;Polymers;Predisposition;premature;progressive hearing loss;Protein Isoforms;Proteins;repaired;Resolution;Rest;Role;Scanning Electron Microscopy;Sensory;Shapes;Signal Transduction;sound;Stereocilium;Structure;Surface;Testing;Thinness;vibration

PROJECT_TITLE: Impact of a DFNA20 Gamma Actin Mutation on Mechanotransduction-Dependent Stereocilia Remodeling


NIH_SPENDING_CATS: Cannabidiol Research;Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Genetics;HIV/AIDS;Infectious Diseases;Natural Products;Neurosciences;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: ATLANTA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Myeloid cells promote chronic inflammation during HIV, that is not suppressed by antiviral therapies, and is a major risk factor for the development of comorbid diseases. We propose to evaluate the anti-inflammatory potential of the phytocannabinoid cannabidiol (CBD) in a rhesus macaque animal model of HIV infection. We anticipate our work will increase understanding of the biological mechanisms by which chronic CBD affects persistent inflammation and the endocannabinoid system in the context of antiretroviral therapy.

PI_NAMEs: WILLIAMS, DIONNA WHITNEY (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Affect;Agonist;Animal Model;Anti-Inflammatory Agents;Anti-viral Response;Anti-viral Therapy;Antiinflammatory Effect;antiretroviral therapy;Anxiety;anxiety symptoms;Biological;Blood;Brain;Cannabidiol;Cannabinoids;Cannabis;CCL2 gene;Cell Lineage;Cells;Central Nervous System;Chronic;CNR1 gene;CNR2 gene;comorbidity;cytokine;daily functioning;Data;depressive symptoms;Development;Disease;Effectiveness;endogenous cannabinoid system;Exposure to;Functional disorder;Genes;genetic signature;Goals;GPR55 receptor;HIV;HIV Infections;immune activation;immunoregulation;Impaired cognition;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;insight;interest;Interferon Activation;Interferon-beta;Interferons;Interleukin-10;Interleukin-12;Interleukin-6;Knowledge;Macaca;Macaca mulatta;Macrophage;Mediating;Mediator;Medical;Mental Depression;Microglia;Modeling;Modernization;monocyte;Myelogenous;Myeloid Cells;Nausea;Nervous System Physiology;neuroAIDS;Neurodegenerative Disorders;neuroinflammation;neuroprotection;NF-kappa B;novel;Oral Administration;Organ;Pain;Pathway interactions;Peripheral;Peripheral Nervous System;Persons;Pharmaceutical Preparations;phytocannabinoid;Population;Prevalence;Process;Property;receptor;Receptor Inhibition;Recreation;reduce symptoms;Regulator Genes;Risk Factors;Role;Signal Transduction;SIV;Source;Therapeutic;Tissues;TNF gene;TNFSF10 gene;transcriptome;transcriptome sequencing;transcriptomics;Viral;Viral Genes;Virus Replication;wasting;Work

PROJECT_TITLE: Cannabidiol and Macrophage Chronic Inflammation in a Virally Suppressed Rhesus Macaque Model


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Social Determinants of Health;Substance Misuse

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Human socioeconomic status is one of the strongest predictors of health and mortality, however little is known regarding the neurobiological mechanisms predisposing individuals of low social status to neuropsychiatric disorders such as alcohol use disorder. This proposal will determine if social anxiety underlies social rank and social isolation-associated alcohol drinking and if amygdala or cortical glial activation is predictive of this behavior. The findings will advance our conceptual framework for neuroimmune regulation of circuits and behavioral factors underlying social rank and isolation-associated alcohol drinking.

PI_NAMEs: PATEL, REESHA  (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: addiction;Alcohol consumption;alcohol use disorder;Alcohols;Amygdaloid structure;Award;behavior prediction;Behavioral;Brain region;Communities;Data;Doctor of Philosophy;drinking;Emotions;Environment;Foundations;Funding;glial activation;Goals;Health;Human;Immune signaling;Individual;Individual Differences;insight;Knowledge;Link;Medial;Mediating;meetings;Mentorship;Microglia;mortality;Motivation;Mus;National Institute on Alcohol Abuse and Alcoholism;neurobiological mechanism;Neuroimmune;neuropsychiatric disorder;Neurosciences;nonhuman primate;parent grant;Pathologic;Pattern;Peer Review;Pharmaceutical Preparations;Prefrontal Cortex;programs;Publications;Regulation;response;Risk Factors;Rodent;Role;Science;Signal Transduction;skill acquisition;social;social anxiety;social determinants;Social Hierarchy;Social isolation;Social status;social stress;Socioeconomic Status;Stress;stressor;Techniques;Training;Underrepresented Populations;virtual

PROJECT_TITLE: Corticolimbic Neuroimmune Determinants of Social Stress-Associated Alcohol Drinking

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_NAME: CRITICAL PATH INSTITUTE

PHR: NARRATIVE Alzheimer’s disease (AD) is a progressive disease of increasing cognitive impairment leading to dementia that impacts the ability of people living with AD to function independently and carry out activities of daily living (e.g., household chores and personal care); however, current endpoint measures in AD clinical trials are not sensitive at early stages of the disease and provide inadequate measurement of cognition-dependent day-to-day functioning. The overall objective of this project is to prepare and submit a Qualification Plan to support the qualification of the Virtual Reality Functional Capacity Assessment Tool – Short List for use as a performance outcome measure of day-to-day functioning (based on evaluation of cognition-dependent instrumental activities of daily living) among individuals diagnosed with Stage 2 and Stage 3 AD. The impact of this work will be the advancement of a publicly available, psychometrically sound measure of cognition-dependent day-to-day functioning that can be used in AD treatment trials to better assess and understand the impact of new treatments on performance of tasks that reflect essential aspects of day-to-day functioning in individuals with Stage 2 and Stage 3 biomarker-positive AD.

PI_NAMEs: EREMENCO, SONYA  (contact)

PROJECT_TITLE: Development of a Qualification Plan for the Virtual Reality Functional Capacity Assessment Tool - Short List (VRFCAT-SLx) (DDT COA #000004)

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CDER-T (18)]


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Racial and Ethnic Minority Health Research;Rehabilitation

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

PHR: Project Narrative Although bilingualism is common among children in the U.S., there is little research examining the language development of bilingual children with hearing loss. This Administrative Diversity Supplement will train a Latina, bilingual post-baccalaureate researcher to transcribe the content of preschool children’s English and Spanish language use, assess the reliability of automated methods of transcription, and assist in interpreting project analyses to characterize the content of bilingual language of preschoolers with and without hearing loss. These efforts will pave the way for classroom-based interventions to enhance the language development of bilingual children with hearing loss.

PI_NAMEs: MESSINGER, DANIEL S (contact);PERRY, LYNN K

PROJECT_TERMS: Administrative Supplement;automated speech recognition;bilingualism;Child;Child Development;Computer Models;Data;deep neural network;Development;experience;Exposure to;Genetic Transcription;Goals;Hearing;hearing impairment;Intervention;knowledge base;Language;Language Development;Latina;Leadership;Length;lexical;Location;Manuals;Measures;Mentors;Methods;Noise;Nursery Schools;Parents;peer;Population Heterogeneity;Postbaccalaureate;Preschool Child;privacy preservation;Production;Research;Research Personnel;Research Training;response;skills;social contact;Spanish/English;Speech;Statistical Study;teacher;tool;Training;vocalization;Writing

PROJECT_TITLE: Characterizing the content of bilingual language in preschoolers with HL


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PI_NAMEs: MILOSAVLJEVIC, ALEKSANDAR  (contact)

PROGRAM_OFFICER_NAME: KANO, KRISTIN KATHLEEN

PROJECT_TERMS: Acceleration;Address;Alleles;Area;Authorization documentation;Binding;Child;Chromatin;Clinical;clinical diagnostics;Code;Collaborations;Communication;Data;data modeling;data portal;Data Set;design;DNA Methylation;Environment;epigenome;extracellular;Funding;Genetic Transcription;genetic variant;genome resource;Genomics;Genotype-Tissue Expression Project;Glean;Haplotypes;improved;indexing;Individual;infrastructure development;Internet;interoperability;Letters;multiple datasets;multiple omics;National Human Genome Research Institute;Participant;Phase;privacy protection;Regulatory Element;Research;Resources;RNA;System;Tissues;transcription factor;United States National Institutes of Health;Untranslated RNA;Validation;Variant

PROJECT_TITLE: GENOMIC INDEXING OF COMMON FUND DATASETS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN ANTONIO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: This study extends an existing national longitudinal study of aging and health in Mexico, with two additional waves of core data collection and one more wave of its ancillary study on cognitive aging, The resulting public use databases will extend over twenty-six years. Highly comparable to similar studies in the U.S. and other countries, the study will allow enhanced research on aging, Alzheimer's disease and related dementias, health, and mortality in a rapidly aging developing country with limited institutional support for the elderly, and with long-lived health, economic, and social ties to the U.S.

PI_NAMEs: WONG, REBECA  (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Address;Adult;aged;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Ancillary Study;bilingualism;Blood;Cognitive;Cognitive aging;cognitive function;Cohort Analysis;Collaborations;Communities;Country;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Collection;data enclave;data platform;Databases;design;Developing Countries;Dimensions;Discrimination;DNA Methylation;Documentation;Economics;Elderly;empowerment;Environmental Risk Factor;Epigenetic Process;Equity;experience;Family;family support;follow-up;Fostering;Funding;Genetic;Geography;Geriatrics;Goals;Health;Health and Retirement Study;Health behavior;health care availability;Health Technology;Healthcare;human old age (65+);improved;Income;Individual;Inequity;Institution;instrument;Interdisciplinary Study;Knowledge;Language;Latin America;Lead;Length;Life Cycle Stages;Link;Longitudinal Studies;Mental Health;Mexican;Mexico;migration;mobile computing;mortality;older adult;outreach;Participant;Peer Review;perceived discrimination;physical conditioning;Physical Function;Population;population based;Positioning Attribute;preservation;programs;Protocols documentation;Research;Research Personnel;Research Support;response;Retirement;Running;Rural;rural area;Saliva;saliva sample;Sampling;social;Social Protection;Spanish/English;statistics;Structure;Surveys;trend;United States;United States National Institutes of Health;usability;user-friendly;Venous;virtual;web platform;web site;Work

PROJECT_TITLE: The Mexican Health Aging Study (MHAS)

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


PHR: NARRATIVE Heart failure is a major worldwide health problem associated with signs and symptoms such as breathlessness with exertion, shortness of breath, fatigue, tiredness or weakness, difficulty breathing when lying down, sleeping problems, swollen legs or ankles, and weight gain, which can negatively impact health-related quality of life and physical function. The ability to properly assess symptoms in persons with heart failure is important in order to evaluate the effectiveness of therapies, inform clinical decision-making, and improve patient-centered outcomes beyond the more traditional measures of hospitalization and mortality; therefore, the overall objective of this project is to conduct quantitative analyses of an existing cross-sectional dataset and prepare a quantitative study report to support the qualification of the Chronic Heart Failure Symptom Scale (CHF-SS) as a patient-reported outcome (PRO) measure of chronic heart failure (CHF) symptom severity in individuals diagnosed with CHF. Although multiple clinical outcome assessments (COAs), specifically PRO measures, have been developed and tested against the scientific processes of their time and widely used in evaluating heart failure interventions, they each present their own limitations with respect to the recent FDA COA-related guidances; given these limitations, qualifying the CHF-SS will fill a critical gap as a publicly available, psychometrically sound measure of symptom severity in CHF treatment trials according to the most recent, rigorous standards and best practices for developing fit-for-purpose COAs for regulatory decision making.

PI_NAMEs: MATTERA, MARIA  (contact)

PROJECT_TITLE: Psychometric Analyses and Quantitative Study Report for Qualification of the Chronic Heart Failure Symptom Scale (CHF-SS) (DDT COA #000112)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This diversity supplement to the parent grant, the National Consortium on Alcohol and Neurodevelopment in Adolescence - Adulthood (NCANDA-A): Administrative Resource (U24 AA021695), will extend analyses to patterns and predictors of abstinence and changes in behavior within minority adolescents and young adults participating in the four-week monitored abstinence Recovery protocol. Analysis of social determinants of behavioral and mental health outcomes for young adults able to abstain from alcohol for a month will assist in understanding potential differences across socioeconomic status and race/ ethnic groups.

PI_NAMEs: BROWN, SANDRA A;TAPERT, SUSAN F (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: Abstinence;Acceleration;Acute;Adolescence;Adolescent;Adolescent and Young Adult;Adolescent Behavior;adolescent substance use;Adult;Affect;alcohol abstinence;alcohol consequences;Alcohol consumption;alcohol cue;alcohol risk;alcohol use disorder;Alcohols;Anxiety;Behavior;behavioral health;binge drinking;Black race;Brain;Caucasians;Cognition;Communities;community-level factor;cue reactivity;Data Analyses;data collection site;Development;disadvantaged background;economic indicator;ethnic difference;ethnic minority;Ethnic Origin;Ethnic Population;Etiology;Evaluation;Future;Goals;graduate school preparation;gray matter;Health;Heart Rate;Heavy Drinking;Hispanic;Household;improved;Individual;Latinx;Learning;Low income;medical specialties;meetings;member;Memory;Mental Depression;Mental Health;Mentors;Mentorship;minority children;Minority Groups;Monitor;Neighborhoods;neurodevelopment;Neuropsychology;Not Hispanic or Latino;Outcome;parent grant;Patient Self-Report;Pattern;Physical activity;Postbaccalaureate;Process;prolonged abstinence;protective factors;Protocols documentation;Psychosocial Factor;racial difference;racial population;Radial;Recording of previous events;Recovery;Research;Research Personnel;Research Project Grants;Research Support;resilience;Resources;responsible research conduct;Rest;Risk Factors;Sex Differences;Sex Differentiation;Shapes;Site;skills;Sleep;social contact;social determinants;social health determinants;Social Interaction;Socioeconomic Status;socioeconomics;substance use;Testing;Time;Training;underage drinking;Work;Writing;young adult

PROJECT_TITLE: National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA): Administrative Resource


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Following guidance from the FDA for biomarker development we aim to qualify the change in bone mineral density (BMD) as a surrogate endpoint for osteoporotic fractures in future drug development, thereby facilitating smaller and shorter trials, greatly decreasing drug development costs. We have compiled individual patient data from >50 clinical trials in osteoporosis, and to date, our analyses reveal a strong relationship between larger increases in BMD and greater fracture reductions. Working with the FDA, we have submitted our Full Qualification Package, the final step in the biomarker qualification process, with the goal to obtain the first-ever formal approval of a surrogate endpoint marker under the new FDA guidelines.

PI_NAMEs: BLACK, DENNIS M (contact)

PROJECT_TITLE: DDT-BMQ-000054: Planning for biomarker qualification, implementation and dissemination for BMD as a surrogate biomarker in future osteoporosis treatment trials: the SABRE project


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Sleep Research

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Despite the importance of sleep for health and the prevalence of sleep disorders, the regulation of sleep remains poorly understood. We will use zebrafish to explore the potential role of astrocytes in regulating sleep homeostasis. These studies may identify new mechanisms that regulate sleep that may eventually lead to new therapies for sleep disorders.

PI_NAMEs: PROBER, DAVID AARON (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Ablation;Address;Astrocytes;Bachelor's Degree;Behavioral;Behavioral Assay;Biological Models;Brain;Calcium;career;career development;Cells;Communities;Complement;computerized tools;cost;Cues;Custom;Data;Data Analyses;Development;Development Plans;direct application;disability;Doctor of Philosophy;Drosophila genus;Economic Burden;Education;Ensure;experience;experimental study;Feedback;Fellowship;Genetic;Genetic Research;Goals;graduate student;Grant;Health;Homeostasis;Image;improved;Individual;Journals;Learning;Lighting;Link;loss of function;Mental disorders;Mentors;Microscope;Modeling;Molecular and Cellular Biology;Morbidity - disease rate;Mus;Nematoda;Neuroglia;Neurons;Neurosciences;novel therapeutics;optogenetics;Oral;parent grant;Parents;poor sleep;Population;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Prevalence;Process;Publishing;Research;Resolution;Role;Scientific Advances and Accomplishments;Scientist;Series;skills;Sleep;sleep abnormalities;Sleep Disorders;Sleep Disorders Therapy;sleep health;sleep regulation;Societies;student training;success;symposium;synergism;Techniques;Testing;Training;two-photon;United States National Institutes of Health;Writing;Zebrafish

PROJECT_TITLE: Genetic and Neuronal Mechanisms that Regulate Zebrafish Sleep - DIVERSITY SUPPLEMENT


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Complementary and Integrative Health;Prevention

ORG_CITY: MONROVIA

ORG_NAME: CHROMOLOGIC, LLC

PI_NAMEs: ROGERS, CLAUDE  (contact)

PROJECT_TERMS: Acute;Animal Model;Animals;Biological Markers;cytokine;design and construction;Development;efficacy testing;gastrointestinal;Generations;In Vitro;Interferon-beta;interleukin-22;Lactobacillus reuteri;Licensing;Mus;prevent;Probiotics;radiation mitigator;Radiation Syndromes;Safety;Technology;Universities;Wisconsin

PROJECT_TITLE: Development of second-generation probiotics as radiation mitigators


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: NARRATIVE Pulmonary arterial hypertension (PAH) is a progressive disease caused by functional and structural changes in the pulmonary vasculature, which lead to increased pulmonary vascular resistance and eventually right ventricular failure and death. Despite recent advances, there remains a need for improved understanding of PAH pathophysiology and a need for improved therapeutic options for these patients, as current therapies are severely limited. The cytokine/enzyme, nicotinamide phosphoribosyl-transferase (NAMPT) binds to TLR4 to promote vascular cell resistance to apoptosis, cell proliferation, and smooth muscle cell survival, all processes implicated in pulmonary vascular remodeling; therefore, we hypothesize that eNAMPT is an important therapeutic target in PAH pathobiology.

PI_NAMEs: RODRIGUEZ, MARISELA  (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Address;Antioxidants;Apoptosis;ATP-Binding Cassette Transporters;Binding;Blood Vessels;Cell membrane;Cell Proliferation;Cell Separation;Cell Survival;Cells;Cessation of life;curative treatments;cytokine;Dimerization;Disease;Endothelial Cells;Endothelin-1;Endothelium;Enzymes;Epithelium;extracellular;extracellular vesicles;Functional disorder;Generations;Genetic Transcription;Genomics;Human;Hypertrophy;Hypoxia;improved;Inflammasome;Inflammatory;Inflammatory Response;inhibitor;insight;Laboratories;Leukocytes;Ligation;Luciferases;Lung;Lymphocyte;Medial;Mesenchymal;Molecular;mutant;Natural Immunity;neutralizing monoclonal antibodies;Nicotinamide adenine dinucleotide;nicotinamide phosphoribosyltransferase;novel;Pathway interactions;Patients;Pattern;pharmacologic;Plasma;Platelet-Derived Growth Factor;pre-clinical;Predisposition;Process;Procollagen-Proline Dioxygenase;Progressive Disease;Proliferating;promoter;Proteins;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary artery structure;Pulmonary Circulation;Pulmonary Fibrosis;pulmonary vascular remodeling;Pulmonary Vascular Resistance;Reporter;Resistance;response;Response Elements;Right Ventricular Dysfunction;right ventricular failure;Right Ventricular Function;Rodent;Role;Severities;Signal Transduction;Smooth Muscle Myocytes;Stimulus;Tertiary Protein Structure;Therapeutic;therapeutic target;Tissues;TLR4 gene;Training;transcription factor;Transcriptional Regulation;Translations;Vascular Endothelial Growth Factors;Vascular remodeling

PROJECT_TITLE: Novel mechanism for eNAMPT secretion in PAH vascular remodeling


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD)

ORG_CITY: PROVO

ORG_DEPT: BIOLOGY

ORG_NAME: BRIGHAM YOUNG UNIVERSITY

ORG_STATE: UT

PHR: Single-cell proteomics (SCP) has potential to revolutionize biologist’s understanding of how individual cells function in complex systems. SCP in its current state provides a shallow profile of cellular proteins and quantitative values with high variance. This proposal describes the first ever dedicated software for SCP analysis and should greatly improve sensitivity for peptide detection and improve accuracy for quantification.

PI_NAMEs: PAYNE, SAMUEL H (contact);SHORTREED, MICHAEL R

PROGRAM_OFFICER_NAME: YUAN, JEAN

PROJECT_TERMS: Algorithms;Atlases;Benchmarking;Biological Process;Categories;Cell Physiology;cell type;Cells;Characteristics;Complex;computational atlas;Computer software;computerized tools;cost;Coupled;Data;data acquisition;data archive;Dedications;design;Detection;Environment;expectation;Feedback;Goals;Heterogeneity;improved;Individual;instrumentation;Ions;Label;Laboratories;Libraries;Life;Link;mass spectrometer;Mass Spectrum Analysis;Metabolic;Nature;Neurons;Noise;novel;Peptides;Performance;Preparation;Proteins;Proteome;Proteomics;Proxy;Research;RNA;Sampling;Signal Transduction;single cell analysis;single-cell RNA sequencing;software development;Software Tools;Spinal Cord;supervised learning;System;Technology;Tissues;Transcript;transfer learning;Work

PROJECT_TITLE: Enhanced Sensitivity and Quantitative Precision for Single Cell Proteomics

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: NARRATIVE Heart disease is the leading cause of death in the United States and worldwide. This proposal seeks to understand how key proteins in the heart normally function, and how their altered behavior contributes to heart disease. The results will increase our understanding of molecular mechanisms of heart disease, and lay the foundation for the development of effective new treatments.

PI_NAMEs: COLECRAFT, HENRY M. (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Address;Adrenergic Agents;Affect;Aging;Animal Model;Behavior;Calcium;Calcium Channel;Calcium Signaling;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cause of Death;Cells;Chronic stress;cohort;Collaborations;combat;Complex;Consanguinity;Coupling;Data;Development;Disease;Disease Progression;Dissection;DNA Sequence Alteration;effective therapy;experimental study;fighting;foot;Foundations;Functional disorder;genetic regulatory protein;genome resource;Genotype;Goals;Health;Heart;Heart Diseases;Heart failure;heart function;Human;Individual;innovation;insight;Knock-out;Knowledge;Link;loss of function mutation;Mediating;Missense Mutation;Molecular;Mus;Mutation;Myocardial dysfunction;Myocardium;nanobodies;nanoengineering;new therapeutic target;novel therapeutics;Pakistan;Pathology;Pathway interactions;Phenotype;phenotypic data;Physiological;Physiology;Population;Post-Translational Protein Processing;Prevalence;prevent;Program Research Project Grants;Proteins;receptor function;Recording of previous events;Regulation;Regulatory Pathway;Research;response;Role;Ryanodine Receptor Calcium Release Channel;Signal Transduction;single molecule;Stress;structural biology;Structure;Surface;therapeutic target;tool;trafficking;United States;Variant

PROJECT_TITLE: Structure-Function of Calcium Channel Complexes in Cardiac Physiology and Disease

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(JA)]