NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Hematology;Hodgkin's Disease;Immunization;Infectious Diseases;Lymphatic Research;Lymphoma;Nanotechnology;Prevention;Rare Diseases;Vaccine Related

PROJECT_TERMS: Adopted;Adult;Animal Model;Animals;Antibodies;B-Cell Receptor Binding;B-Lymphocytes;Binding;Biological Assay;Burkitt Lymphoma;cancer cell;Cell fusion;Cells;Clinic;clinical center;Complex;Congenital Abnormality;Control Animal;Crystallography;Cytomegalovirus;Cytomegalovirus Infections;design;Disease;Electron Microscopy;Epithelial Cells;Epstein-Barr Virus Infections;Epstein-Barr Virus-Related Lymphoma;Epstein-Barr Virus-Related Malignant Neoplasm;Ferrets;Ferritin;Globulins;Glycoproteins;Goals;Herpesviridae;Herpesvirus Vaccines;Hodgkin Disease;Human;Human Herpesvirus 4;humanized mouse;Immune;Immune response;Immunoglobulin G;in vivo;Infection;Infectious Mononucleosis;Knowledge;Licensing;Lymphoproliferative Disorders;Mediating;Membrane Fusion;Minnesota;Molecular Conformation;Monoclonal Antibodies;Mus;nanoparticle;Nasopharynx Carcinoma;neutralizing antibody;nonhuman primate;Pathogenesis;Patients;phase I trial;Phase I/II Trial;Population;post-transplant;prevent;Prophylactic treatment;receptor binding;Reporting;self assembly;Site;Stomach Carcinoma;Structure;Testing;Therapeutic;Therapeutic antibodies;United States National Institutes of Health;Universities;Vaccinated;vaccine candidate;vaccine development;Vaccines;Viral;Viremia;Virus;Virus Diseases;X-Linked lymphoproliferative disorders

PROJECT_TITLE: Herpesvirus Pathogenesis and Vaccine Development


ACTIVITY: ZIA

ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

PI_NAMEs: CHESEBRO, BRUCE  (contact)

PROJECT_TERMS: Address;Affect;Animals;Biochemical;Biological Assay;Brain;cervid;Chronic Wasting Disease;Clinical;cross-species transmission;Deer;Disease;disease transmission;experimental study;Failure;False Positive Reactions;Genes;Genetic Polymorphism;Geographic Locations;Human;Infection;insight;Macaca;Macaca fascicularis;Modeling;Mus;Nature;Nervous System Disorder;Neurologic Signs;neuropathology;nonhuman primate;Oral;overexpression;Pathologic;Predisposition;prevent;Prion Diseases;prion seeds;Prions;Property;PrP;Reaction;Reindeer;Relative Risks;Residual state;Route;Saimiri;Sampling;Testing;Tissues;Transgenic Mice;transmission process;United States;Zoonoses

PROJECT_TITLE: Study of CWD Deer and Elk Prion Disease in Nonhuman Primates and transgenic mice


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Influenza;Lung;Orphan Drug;Orthopoxviruses;Pneumonia and Influenza;Prevention;Rare Diseases;Vaccine Related

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PI_NAMEs: DAVEY, RICHARD  (contact)

PROJECT_TERMS: 2019-nCoV;Acute;Adrenal Cortex Hormones;Adult;Africa;African;anti-influenza;Anti-viral Agents;Antibodies;Antibody Response;Antibody titer measurement;arm;Avidity;B-Lymphocytes;Birds;booster vaccine;care systems;Caring;Childhood;Clinical;clinical center;Clinical Research;Clinical Trials;Cohort Analysis;Collaborations;Communicable Diseases;Communities;Consensus;Containment;Coronavirus;Country;COVID-19;COVID-19 patient;COVID-19 therapeutics;COVID-19 treatment;Democratic Republic of the Congo;design;Development;Dexamethasone;Disease Outbreaks;Disease Outcome;Dose;Double-Blind Method;double-blind placebo controlled trial;Ebola;Ebola Hemorrhagic Fever;Ebola virus;effective therapy;Emergency Situation;Emerging Communicable Diseases;Enrollment;epidemic potential;epidemic virus;Exposure to;Funding;Goals;Harvest;Health Personnel;Healthcare;high risk;Hospitalization;Human;Human Resources;Immunization;Immunize;immunogenicity;Immunologics;Immunotherapeutic agent;improved;Infection;Infectious Agent;Influenza;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H5N1 Subtype;Influenza A Virus, H7N9 Subtype;Influenza B Virus;influenza virus strain;influenzavirus;Inpatients;insight;interest;International;Intervention;Intravenous Immunoglobulins;Investigation;Investigational Therapies;Laboratories;Lead;Leadership;lectures;Licensing;Licensure;Medical;medical countermeasure;meetings;men who have sex with men;Methods;Microbiology;Middle East Respiratory Syndrome Coronavirus;Monkeypox;Monoclonal Antibodies;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;Nebraska;novel;novel coronavirus;Outcome;pandemic coronavirus;pandemic disease;Participant;participant enrollment;pathogen;Patient Care;Patients;pediatric patients;Performance;Pharmaceutical Preparations;Phase;Phase II/III Trial;Placebo Control;Placebos;Plasma;Population;Poxviridae;pre-clinical;pre-exposure prophylaxis;pre-pandemic;prevent;Preventive vaccine;Process;Prophylactic treatment;Protocols documentation;Public Health;Publications;Publishing;Randomized;Randomized Controlled Clinical Trials;randomized placebo controlled trial;randomized, clinical trials;Recombinants;Recording of previous events;remdesivir;Research;respiratory;respiratory pathogen;Respiratory Tract Infections;response;Risk;Role;Route;Safety;Sampling;Schedule;seasonal influenza;Seasons;Secondary Immunization;Severe Acute Respiratory Syndrome;Sudan;Surface;SYK gene;symposium;Testing;Therapeutic;Time;Training;Training and Education;treatment center;treatment strategy;treatment trial;Tyrosine Kinase Inhibitor;United States;United States National Institutes of Health;Universities;Vaccinated;Vaccination;vaccination protocol;vaccine evaluation;Vaccines;Validation;Variant;Vertebral column;Vesicular stomatitis Indiana virus;Viral;Virus;Virus Diseases;Zaire Ebola virus

PROJECT_TITLE: Influenza and Emerging Infectious Diseases


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

PI_NAMEs: TAUBENBERGER, JEFFERY  (contact)

PROJECT_TERMS: 1918 influenza pandemic;Animal Experiments;Annual Reports;Avian Influenza;B-Lymphocytes;Birds;Cattle;Cessation of life;clinical development;Country;Dairying;Disease Progression;Domestic Fowls;enzootic;Epidemic;epizootic;Family suidae;future pandemic;Goals;Hemagglutinin;Human;human pathogen;Infection;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H5N1 Subtype;Influenza A Virus, H7N9 Subtype;influenza epidemic;influenza infection;Influenza prevention;influenza virus vaccine;insight;Integration Host Factors;Mammals;Maps;Modeling;Morbidity - disease rate;mortality;new pandemic;novel;novel therapeutic intervention;novel therapeutics;novel vaccines;pandemic disease;pandemic influenza;pandemic potential;pandemic virus;Pathogenesis;pathogenic virus;Pathogenicity;Persons;prevent;previous pandemic;protective efficacy;Public Health;Reporting;T-Lymphocyte Epitopes;universal influenza vaccine;universal vaccine;vaccine strategy;Vaccines;Viral;Viral Genome;Viral Pathogenesis;Virulence Factors;Virus;Virus Diseases;wild bird;Work

PROJECT_TITLE: Influenza Viral Pathogenesis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Zika Virus

PI_NAMEs: WHITEHEAD, STEPHEN  (contact)

PROJECT_TERMS: Admixture;Age;age group;Anti-viral Agents;Area;Attenuated;Attenuated Vaccines;Bangladesh;biodefense;Biological Assay;Brazil;CD8-Positive T-Lymphocytes;Cells;Child;Clinical;clinical development;Clinical Research;clinical research site;Clinical Trials;Contracts;Cooperative Research and Development Agreement;cross immunity;cross reactivity;Culicidae;Cyclic GMP;Dengue;Dengue Vaccine;Dengue Virus;Development;Dose;effectiveness evaluation;Ensure;Evaluation;Exposure to;feeding;Flavivirus;Formulation;Goals;Human;Immune response;Immunization;immunogenic;immunogenicity;improved;India;Infant;Infection;Innate Immune Response;Intention;Intervention;Laboratories;Manufacturer;Medical;men;MicroRNAs;Modeling;Mus;National Institute of Allergy and Infectious Disease;Neurologic;neutralizing antibody;Nicaragua;novel;older adult;panacea;Participant;pathogen;Phase;phase 3 testing;Phenotype;Placenta;Preparation;Publications;reproductive;Research;research clinical testing;response;Risk;Safety;Sampling;seropositive;Serotyping;Serum;T cell response;Taiwan;Technology;Testing;Tissues;transmission process;Tropism;United States;Vaccination;vaccine candidate;vaccine development;vaccine evaluation;vaccine response;Vaccines;Vietnam;Virus;Virus Replication;Woman;Zika Virus;Zika virus vaccine

PROJECT_TITLE: Clinical Trials of  Biodefense Vaccines (Dengue)


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Gene Therapy;Genetics;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: KANG, ELIZABETH  (contact)

PROJECT_TERMS: adverse outcome;Agreement;Allogenic;Amendment;Antibodies;autoinflammatory;Autologous;Autologous Transplantation;autosome;Biological Products;Blood;Bone Marrow;Bone Marrow Transplantation;Busulfan;Cells;Cerebral hemisphere hemorrhage;Characteristics;chemotherapeutic agent;Chimerism;Clinical;clinical application;Clinical Immunology;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Complication;conditioning;congenital immunodeficiency;curative treatments;Cyclophosphamide;cytokine;Data;Development;Disease;Dose;Eligibility Determination;Engraftment;Enrollment;Evaluation;Exclusion;follow-up;Future;Gene Modified;gene therapy;gene therapy clinical trial;Genetic;genetically modified cells;Goals;graduate school;Graft Rejection;graft vs host disease;Heart;Hematopoietic;Hematopoietic stem cells;high risk;Homologous Transplantation;Hypersensitivity;Idiopathic Thrombocytopenic Purpura;immunodeficiency;improved;improved outcome;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inflammatory milieu;Institutional Review Boards;Interferon Type II;Journals;Laboratories;Lentivirus Vector;London;Lung;MabCampath;Malignant - descriptor;Malignant Neoplasms;Medical;medical schools;Medicine;meetings;member;Methods;microbiome analysis;Modification;mortality;mortality risk;mouse model;Mucositis;Mus;Mycoses;Nature;Non-Malignant;North America;novel;Outcome;Oxidases;Pathway interactions;patient subsets;Patients;post-transplant;Postdoctoral Fellow;Protocols documentation;Publications;Publishing;Radiation Dose Unit;Refractory;Regimen;Resolution;Risk;RNA;RNA Sequence Analysis;Sampling;Site;stem cell gene therapy;stem cell therapy;Stem cell transplant;Syndrome;Techniques;Testing;tocilizumab;Toxic effect;transduction efficiency;transplant model;Transplant Recipients;Transplantation;United States National Institutes of Health;vector;Work;Zea

PROJECT_TITLE: Development and conduct of allogeneic stem cell transplant and autologous stem cell gene therapy for inherited immune deficiencies


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Genetics;Hepatitis;Hepatitis - B;Immunotherapy;Infectious Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases;Transplantation

PI_NAMEs: FARCI, PATRIZIA  (contact)

PROJECT_TERMS: Accounting;Acute;Acute Hepatitis;acute infection;acute liver disease;Acute Liver Failure;Affect;Age;Allografting;Animal Model;Antigen Presentation;Apoptosis;B-Lymphocytes;Basic Science;Biological Markers;Biology;burden of illness;Cancer Etiology;carcinogenesis;Caucasians;Cause of Death;Cessation of life;Chronic;Chronic Hepatitis;Chronic Hepatitis B;Chronic Hepatitis D;chronic infection;chronic liver disease;Chronic viral hepatitis;Cirrhosis;Clinical;Clinical Research;Cohort Studies;Collaborations;Communicable Diseases;Comparative Study;Complex;Complication;CTLA4 gene;CTNNB1 gene;cytokine;Data;Death Rate;Development;Diagnosis;Disease Progression;Early identification;Etiology;exome sequencing;Functional disorder;Future;Genes;Genotype;Gerbils;Goals;HBV Genotype;Hepatic;Hepatitis;Hepatitis A;Hepatitis B;Hepatitis B e Antigens;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Vaccines;Hepatitis B Virus;Hepatitis C virus;Hepatitis Delta Virus;Hepatitis E virus;Hepatitis Viruses;Hepatocarcinogenesis;Hepatocyte;high risk;Human;Immune;Immune checkpoint inhibitor;Immune response;Immunocompetent;Immunocompromised Host;Immunoglobulin M;Immunohistochemistry;Immunophenotyping;immunosuppressed;Immunosuppression;Immunotherapy;Implant;In Vitro;Individual;Infection;Infiltration;Inflammation;innovation;insight;Integration Host Factors;Knowledge;Liver;Liver Cirrhosis;Liver diseases;Liver Failure;Liver Fibrosis;liver injury;long-term sequelae;Lymphocytic Infiltrate;Mediating;Medical center;Missense Mutation;Modeling;Molecular;mutant;Mutation;Nature;novel strategies;Nucleotides;Oncogenic;organ transplant recipient;Outcome;Pathogenesis;Pathogenicity;Patients;Persons;Pharmaceutical Preparations;Phenotype;Play;Population;Population Heterogeneity;predictive marker;Prevention strategy;Primary carcinoma of the liver cells;programmed cell death ligand 1;programmed cell death protein 1;programs;Public Health;Reporting;Research;response;Risk Factors;Role;Sampling;Series;Serology;Serum;Solid;Specimen;subcutaneous;Symbiosis;System;T-Lymphocyte;Tacrolimus;Tissues;transcriptomics;Transplantation;Tuberculosis;tumor;tumor microenvironment;Tumor Subtype;Universities;Viral;viral DNA;Viral hepatitis;Viral Pathogenesis;viral RNA;Viremia;Virus;Virus Diseases;virus infection mechanism;Virus Replication;Virus Shedding;World Health Organization

PROJECT_TITLE: Molecular Mechanisms of Pathogenesis of Acute and Chronic Liver Diseases


NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: DUFFY, PATRICK  (contact)

PROJECT_TERMS: Adjuvant;Alhydrogel;Antibodies;Antigens;Area;Binding;Blocking Antibodies;burden of illness;candidate identification;cohort;Culicidae;Exposure to;Expression Library;Formulation;Frequencies;Genes;Germ Lines;Goals;Human;human monoclonal antibodies;Immunity;Immunization;Immunize;Individual;interest;Investigation;Legal patent;Malaria;malaria transmission;malaria transmission-blocking vaccine;Malaria Vaccines;Methods;Monoclonal Antibodies;novel;Parasites;Participant;Plasmodium;Plasmodium falciparum;prevent;Proteins;Publications;Recombinant Proteins;Recombinants;Reporting;Sampling;screening;Serum;Testing;tool;transmission blocking;transmission process;transmission-blocking vaccine;Vaccination;Vaccine Antigen;vaccine candidate;vaccine discovery;Vaccines;Work

PROJECT_TITLE: Malaria Transmission Blocking Vaccine Discovery


NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PROJECT_TERMS: Adjuvant;Aluminum;aluminum sulfate;Antigens;Area;burden of illness;Carrier Proteins;Collaborations;Communicable Diseases;controlled release;cross reacting material 197;Dedications;Development;Effectiveness;Evaluation;Failure;Formulation;Future;Goals;Human;Immune response;improved;In Vitro;Infection;Interruption;Liposomes;Malaria;malaria transmission;malaria transmission-blocking vaccine;Malaria Vaccines;Membrane;Membrane Proteins;Messenger RNA;Microbiology;Mus;Nature;Needles;Neisseria meningitidis;novel;novel vaccines;Parasites;Parasitic Diseases;Peptide Signal Sequences;Plasmodium;Plasmodium vivax;Polysaccharides;protein complex;Proteins;Publications;Recombinant Proteins;Reporting;RNA vaccine;Salmonella typhi;Sexual Development;success;Surface;Surveys;System;Technology;Testing;Tetanus Toxoid;Transmembrane Domain;transmission blocking;transmission process;transmission-blocking vaccine;vaccine delivery;vaccine development;vaccine platform;Vaccines

PROJECT_TITLE: Optimizing malaria transmission-blocking vaccines with improved platforms


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Rural Health;Vaccine Related;Vector-Borne Diseases

PROJECT_TERMS: Abnormal Hemoglobins;Abnormal Neutrophil;Adjuvant;Adult;Age;aged;Alanine Transaminase;Alhydrogel;Antibody Response;Area;Blood specimen;burden of illness;Carrier Proteins;Child;Clinical;clinical care;Clinical Chemistry;Complete Blood Count;cooking;Creatinine;Databases;Dose;Double-Blind Method;Family;Feeds;Formulation;Hematology;Hemoglobin concentration result;immunogenicity;Individual;Laboratories;Malaria;malaria transmission;Malaria Vaccines;Mali;Manufacturer;Manuscripts;Measurable;mutant;National Institute of Allergy and Infectious Disease;Older Population;Outcome;Parasites;Phase;Plasmodium falciparum;Population;Proteins;Protocols documentation;Pseudomonas aeruginosa;Publications;Randomized;Recombinants;Reference Values;Rural;Safety;screening;sex;Sex Differences;Site;Skin;Surface;Test Result;Toxin;transmission blocking;transmission process;transmission-blocking vaccine;vaccine development;vaccine trial;Vaccines;zygote

PROJECT_TITLE: Malaria Vaccines:  Pfs25-rEPA and Pfs230-rEPA


PI_NAMEs: RIBEIRO, JOSE  (contact)

PROJECT_TERMS: Aedes;Affect;Alternative Complement Pathway;Anaphylatoxins;Anti-Bacterial Agents;Arthropods;assay development;Atlases;Binding;Biochemistry;Bioinformatics;Biological;Biological Assay;biophysical analysis;Blood;Blood Coagulation Factor VII;cancer procoagulant;Clustered Regularly Interspaced Short Palindromic Repeats;Coagulation Process;Collaborations;Complement;Complement 3 Convertase;Complement 3b;Complement Activation;complement C3 precursor;Complement Inactivators;complement system;Complex;Cryoelectron Microscopy;Crystallography;Culicidae;Data;Data Analyses;dimer;Dimerization;disease transmission;Disease Vectors;Dose;Environment;Eukaryotic Cell;Factor VIIa;Factor X;Factor Xa;Fat Body;feeding;Gel Chromatography;Goals;Gram-Negative Bacteria;Hemolymph;Hemostatic Agents;Hemostatic function;hormone binding protein;human tissue;Image;Immune response;Immunity;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Insect Vectors;Insecta;Juvenile Hormones;Knock-out;Link;Lipids;Membrane;Methodology;Methods;microorganism;Molecular;Molecular Mechanisms of Action;mutant;novel;particle;pathogen;Pathogenicity;Pathway interactions;Pharmacologic Actions;Physiology;Preparation;Process;Production;protein purification;Proteins;Proteome;Proteomics;Publishing;Recombinant Proteins;Research;Resolution;response;Role;Saliva;Salivary;Salivary Proteins;Sequence Analysis;Simuliidae;small molecule;Structure;Surface;System;Techniques;Testing;Thromboplastin;tick saliva;Ticks;Tissues;Transcript;transcriptome;transcriptomics;transmission process;vector;Vector-transmitted infectious disease;Work

PROJECT_TITLE: Vector-Borne Diseases: Molecular Mechanisms in Vector-Host Interactions


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: BOSIO, CATHARINE  (contact)

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;Age;Anti-Inflammatory Agents;Attenuated;Attenuated Vaccines;Bacteria;Bordetella pertussis;capsule;Cause of Death;Cell Death;cell type;Cells;Cessation of life;Child;Data;Development;Dose;Early identification;effector T cell;Elements;Francisella;Francisella tularensis;Generations;Genomics;Goals;Image;Imaging technology;Immune response;Immunity;Immunosuppression;Impairment;in vivo;Individual;Infection;Infection prevention;Infectious Agent;Inflammation;Inflammatory Response;Innate Immune Response;insight;Klebsiella pneumoniae;Lipid Synthesis Pathway;lipidomics;Lipids;Location;Lower Respiratory Tract Infection;Lung;Lung infections;lung pathogen;Macrophage;Mediating;Metabolic;Metabolic syndrome;Metabolism;metabolomics;microbial;microorganism;Mitochondria;Modeling;mouse model;multiple omics;Mutation;novel therapeutics;novel vaccines;Obesity;Organ;Outcome;pathogen;Pathogenesis;Pathway interactions;Pattern;Peripheral;Phase;Play;Population;Primary Infection;Production;programs;protective efficacy;Pulmonary tularemia;Recording of previous events;Reproducibility;Resolution;response;Role;Route;secondary infection;Structure;Surface;T cell response;T-Lymphocyte;Tissues;tool;Tularemia;Vaccination;vaccination strategy;Vaccines;Virulent

PROJECT_TITLE: Immunity to Pulmonary Infections


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

PI_NAMEs: GRIGG, MICHAEL  (contact)

PROJECT_TERMS: Acute;Alleles;Animals;Antibodies;Antigens;Attenuated;B-Lymphocytes;Bacterial Adhesins;Binding;Biochemical;CASP1 gene;Categories;Cells;chronic infection;Clinical;Competence;Complement;Complement Factor H;Data;Defect;Deposition;Development;Disease;Disease Outbreaks;Endocrine;Evolution;falls;Female;forward genetics;Foundations;GDF15 gene;genetic approach;Genetic Determinism;Germ Cells;Glycosaminoglycans;Goals;gut microbiome;Heparitin Sulfate;Human;IL18 gene;Ileitis;Immune;Immune signaling;Immunity;Immunologics;immunoregulation;in vivo;Infection;Inflammasome;Inflammatory;Interferon Type II;Interleukin-1 beta;Interleukin-12;Interruption;Invaded;Investigation;knockout gene;Lectin;Life Cycle Stages;male;Mediating;Molecular;mouse model;mucosal site;Mus;mutant;NF-kappa B;Nuclear Translocation;Outcome;overexpression;Parasites;Parasitic infection;Partner in relationship;pathogen;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Pharmaceutical Preparations;Polysaccharides;Predisposition;Production;Proliferating;prophylactic;protein protein interaction;Proteins;recruit;Regulation;Regulatory T-Lymphocyte;response;reverse genetics;Role;sensor;Series;Serology test;Serum;sex;Signal Pathway;Site;Stimulus;Structure;Surface;Surface Antigens;Testing;Therapeutic Intervention;TLR2 gene;TLR4 gene;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;Transgenic Organisms;transmission process;transmission-blocking vaccine;unpublished works;Vaccines;virtual;Virulence;Virulence Factors;Virulent;Work;Zoonoses

PROJECT_TITLE: Toxoplasma Surface Antigens and Immunity


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome;Vector-Borne Diseases

PROJECT_TERMS: Admixture;Animals;Apicomplexa;Area;B-Cell Activation;Biochemical Epidemiology;Birds;Blastocystis;Blood;CD4 Positive T Lymphocytes;Cells;Chronic;Clinical;Communities;Complex;Data;Data Set;Dendritic Cells;Development;diagnostic tool;Disease;Disease Outbreaks;Eimeria;Elements;Entamoeba;Enteral;Environment;Epidemic;Epidemiology;Evolution;fungus;Genetic;Genetic Determinism;genetic epidemiology;Genetic Polymorphism;Genetic Recombination;genetic variant;Genome;genome sequencing;genome wide association study;Genotype;Geography;Giardia;Goals;Growth;gut dysbiosis;gut inflammation;gut microbiota;Homeostasis;host-microbe interactions;Human;Immune;immune function;Immunological Models;Infection;Inflammasome;Inflammation;Inflammatory;insight;interest;Isospora;Leishmania;Life Cycle Stages;Mammals;Metabolic;Metagenomics;microbial;microbial host;microorganism interaction;Modeling;Molecular;Molecular Epidemiology;Nature;Neospora;new therapeutic target;novel diagnostics;Parasites;Parasitic Diseases;Parasitology;Partner in relationship;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Periodicals;Phylogenetic Analysis;Population;population genetic structure;Population Genetics;Prevalence;Protozoa;reconstruction;Recording of previous events;Regulation;Research;response;reverse genetics;Route;Sampling;Sarcocystis;Severity of illness;Sexual Reproduction;Site;Stimulus;Testing;Therapeutic Intervention;Tissues;Toxoplasma;Toxoplasma gondii;transmission process;Trichomonas;Trypanosoma;Variant;Virulence;Virulent;whole genome;Work;Zoonoses

PROJECT_TITLE: Parasite Population Genetics and Inflammation


PI_NAMEs: LONG, CAROLE  (contact)

PROJECT_TERMS: Address;Adjuvant;Adult;African;Anopheles Genus;Antibodies;Antigens;Area;asexual;Attention;B-Lymphocytes;Biological;Biological Assay;Biology;Blood;Blood Tests;Bone Marrow;Burkina Faso;Cells;Characteristics;Child;Clinical;Clinical Trials;Clone Cells;Coculture Techniques;Collaborations;Combined Vaccines;Complex;Culicidae;Cysteine;Data;Development;differentiation in vitro;Disease;efficacy trial;Enzyme-Linked Immunosorbent Assay;Epitopes;Erythrocytes;Evaluation;feeding;Ferritin;first-in-human;Formulation;Future;Generations;Genes;Germ Lines;Goals;Growth;Hepatitis;Human;Immune response;Immune system;Immunity;Immunization;Immunize;immunogenicity;Immunoglobulin G;Immunology;improved;In Vitro;in vivo;Infant;Infection;Interferons;Invaded;Investigation;Investments;Laboratories;Malaria;malaria infection;malaria transmission;Malaria Vaccines;Manuscripts;Mass Spectrum Analysis;Measurement;member;Membrane;Methods;Monoclonal Antibodies;Myeloid Cells;nanoparticle;novel;Oocysts;Parasites;Phase;Phase II Clinical Trials;Plasmodium falciparum;Plasmodium vivax;polyclonal antibody;Preparation;Process;Production;protein complex;Proteins;Recombinants;Reporting;Research;Research Personnel;Resistance development;response;Rodent;Role;Safety;Sampling;Serum;Silk;Standardization;Surface Antigens;System;Testing;Time;tool;Transcript;transcriptome sequencing;transmission process;transmission-blocking vaccine;Universities;vaccine candidate;Vaccines;vector;vector mosquito;Virus-like particle;volunteer;Weight;Work

PROJECT_TITLE: Host Immune Responses to Antigens of Malaria Parasites


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Urologic Diseases;Women's Health Research

PI_NAMEs: LOBANENKOV, VICTOR  (contact)

PROJECT_TERMS: 3-Dimensional;4T1;Adenoviruses;Affect;Alpha Virus;Animals;Antigens;ATAC-seq;Attention;Autologous;Binding;Binding Sites;Breast Cancer Model;Brothers;cancer cell;Cancer cell line;cancer immunotherapy;Cancer Patient;cancer site;cancer stem cell;cancer survival;cancer therapy;Cell Maintenance;cell type;Cells;Cessation of life;chemotherapy;ChIP-seq;Chromatin;chromatin immunoprecipitation;Chromatin Loop;chromatin remodeling;Chromatin Remodeling Factor;Clinic;clinical application;clinical trial protocol;Control Animal;Coupled;CRISPR/Cas technology;Data;Defect;Dendritic Cells;Dependence;Disease;disease diagnosis;Distant;DNA;DNA Binding;DNA Binding Domain;driving force;Elements;Embryo;Endogenous Retroviruses;Epigenetic Process;ERBB2 gene;Experimental Designs;Family;FDA approved;Gametogenesis;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;gene product;Generations;Genes;Genetic;Genetic Transcription;Genome;genome-wide;Genomic Segment;Germ Cells;Germ Lines;Goals;Hi-C;Homologous Gene;Housekeeping;Human;human model;humanized mouse;Immune;Immunize;Immunodiagnostics;immunogenic;Immunotherapeutic agent;Immunotherapy;imprint;improved;In Vitro;in vivo;inhibitor;Journals;K-562;K562 Cells;knock-down;Knock-out;knockout animal;Knockout Mice;Lead;Link;Malignant Breast Neoplasm;Malignant Epithelial Cell;Malignant Neoplasms;Maps;MCF7 cell;Mediating;Meiosis;Methods;Mitotic;Modeling;Molecular;mouse model;Mus;Mutate;MYCN gene;Names;Nature;Neoplasm Metastasis;Neuroblastoma;next generation sequencing;NIH 3T3 Cells;NIH Mouse;Oncogenic;Organ;Outcome;overexpression;paralogous gene;Pathologic;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Play;Population;pre-clinical;Primates;programs;Proliferating;promoter;Protein Isoforms;Proteins;Protocols documentation;Rattus;Recombinants;recruit;Recurrence;refractory cancer;Regulation;Regulatory Element;Reporting;Research;Resistance;Retrotransposon;Role;senescence;Side;Site;Somatic Cell;Specificity;Spermatids;Spermatocytes;Spermatogenesis;stemness;Structure;subfertility;Tandem Repeat Sequences;Testing;Testis;therapy resistant;tissue culture;Tissues;tool;Transcript;Transcription Initiation;Transcription Initiation Site;Transcriptional Activation;transcriptome sequencing;Transfection;Translating;Translational Research;treatment site;tumor;tumor growth;Tumor Suppressor Genes;Ukraine;Undifferentiated;Up-Regulation;Vaccines;virtual;working group;zinc finger nuclease

PROJECT_TITLE: Regulation of CTCF Functions and Target Sites by Cancer/Testis-specific CTCF Like BORIS Factor


NIH_SPENDING_CATS: Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Vaccine Related

PI_NAMEs: MARGULIES, DAVID  (contact)

PROJECT_TERMS: 2019-nCoV;Adaptive Immune System;Address;Amino Acids;Antibodies;Antibody Binding Sites;Antigen Presentation;Antigen Presentation Pathway;Antigens;Benign;Binding;Biochemical;Biochemistry;Biophysics;Cell Communication;Cell surface;Cells;Communicable Diseases;Complement;Complex;complex IV;Coronavirus;Cytomegalovirus;Databases;Degradation Pathway;DNA Viruses;Endoplasmic Reticulum;Engineering;Evolution;experimental study;Family;Frequencies;Functional disorder;Goals;Herpesviridae;Homologous Gene;I-antigen;Immune Evasion;Immune response;Immune system;immunodeficiency;improved;Innate Immune System;Insecta;insight;interest;Intervention;Knowledge;Lead;Major Histocompatibility Complex;Malignant Neoplasms;Mammals;member;Methods;Molecular;molecular dynamics;Molecular Structure;Molluscum Contagiosum;Molluscum contagiosum virus;Murid herpesvirus 1;nanobodies;Natural Killer Cells;Nature;Neoplasms;novel;pathogen;Pathway interactions;Peptides;Poxviridae;Procedures;Proteins;receptor;receptor binding;Recombinants;Role;SARS-CoV-2 spike protein;Site;Structure;Surface;System;T-Cell Receptor;T-Lymphocyte;tapasin;Vaccine Design;vaccine strategy;Vaccine Therapy;Viral;Viral Physiology;Virus;Virus Diseases;Work

PROJECT_TITLE: Structure and Function of Viral Immunoevasins


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PI_NAMEs: BRENCHLEY, JASON  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Address;African;African Green Monkey;Animal Model;Animals;Architecture;arm;Asian;ATAC-seq;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;cell type;Chronic;Chronic Phase;Circulation;Clinical;Data;design;Disease;Disease Progression;Down-Regulation;Elements;Epigenetic Process;Evolution;experience;Gastrointestinal tract structure;Genetic Transcription;High Prevalence;HIV;Human;immune activation;immune function;Immune system;Immune System Diseases;Immunity;immunodeficiency;Immunologics;improved;In Vitro;in vivo;Individual;Infection;Inflammation;interest;Knowledge;Laboratories;Lamina Propria;Lead;Lymphoid Tissue;Macaca;Maintenance;Measures;member;microbial;microbial products;microbiome;Modification;Monkeys;Nature;nonhuman primate;novel therapeutic intervention;Outcome;Pathogenesis;Peripheral;Phase;Philosophy;Population;Primate Lentiviruses;Primates;Productivity;Prognosis;Recording of previous events;Reporting;Research;Resistance;Role;Simian Acquired Immunodeficiency Syndrome;SIV;Study Section;Supporting Cell;Technology;Time;Tissue Sample;Tissues;United States National Institutes of Health;Virus;Virus Replication;Work

PROJECT_TITLE: Mechanisms of Immune Activation and Disease Progression in Animal Models


NIH_SPENDING_CATS: Anthrax;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases

PI_NAMEs: LEPPLA, STEPHEN  (contact)

PROJECT_TERMS: Affect;Animals;Anthrax disease;anthrax toxin;Anthrax Vaccines;Antigens;aptamer;ATP phosphohydrolase;attenuation;Bacillus;Bacillus anthracis;Bacillus subtilis;Bacteria;Bicarbonates;Binding;Binding Sites;Biochemical;candidate identification;capsule;Carbon Dioxide;Cell Death;Cells;Chromosomes;Complex;Consensus;Cysteine;Data;Defect;Development;Disease;DNA Sequence;DNA-Directed RNA Polymerase;edema factor;Electrophoretic Mobility Shift Assay;Enzymes;Escherichia coli;Exclusion;Gene Deletion;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic;genetic manipulation;Genetic Transcription;genome sequencing;Genomics;Glucose;glucose permease;Goals;Growth;Helix-Turn-Helix Motifs;Histidine;Homologous Gene;Human;in silico;In Vitro;in vivo evaluation;Individual;Infection;Learning;lethal factor;Life;Life Cycle Stages;Mediating;Metabolic;Methods;Modification;Molecular Genetics;mouse model;mutant;Mutation Analysis;Nature;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Peptide Hydrolases;permease;peroxiredoxin I;Phosphoenolpyruvate;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Plasmids;Play;Polymerase;Positioning Attribute;Post-Translational Protein Processing;Probability;Process;Production;promoter;Promoter Regions;protein degradation;Protein Kinase;Protein Secretion;Protein-Serine-Threonine Kinases;Proteins;Proteomics;Pyruvate Carboxylase;Regulation;Reporter;Reporting;Reproduction spores;response;RNA;RNA Polymerase II;Role;Sequence Alignment;Serine;Serine Protease;Signal Transduction;Small RNA;Stimulus;sugar;System;Threonine;tool;Toxin;Transcription Coactivator;transcription factor;Transcriptional Regulation;vaccine candidate;Vegetative States;Virulence;Virulence Factors;virulence gene;Virulent;Work

PROJECT_TITLE: Molecular Genetics and Pathogenesis of Anthrax


NIH_SPENDING_CATS: Anthrax;Biodefense and Related Countermeasures;Breast Cancer;Cancer;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention;Rare Diseases;Women's Health Research

PROJECT_TERMS: Adenocarcinoma;adenoma;Adenylate Cyclase;Animal Model;Animals;Anthrax disease;anthrax toxin;antigen binding;Antigens;Area;Bacterial Toxins;Blood Vessels;Breast Epithelial Cells;Breeding;Canis familiaris;Cell Death;Cell model;cell type;Cells;Cessation of life;Chromosome Mapping;Collection;Cyclic AMP;cytokine;Cytoplasm;Development;Disease;disorder control;Dose;edema factor;efficacy testing;Eicosanoids;Engineering;Enterobacteria phage P1 Cre recombinase;enzyme substrate;Event;Extravasation;Family;Future;Genetic Predisposition to Disease;genetic resistance;Goals;Hour;Inbred Strains Mice;Inflammasome;inhibitor;Injections;Innate Immune Response;insight;Intoxication;Laboratories;Learning;lethal factor;Link;Malignant Neoplasms;Mammary Neoplasms;MEKs;Methods;Modification;mouse model;Mus;mutant;Mutation;neoplastic cell;novel;novel strategies;Organ;Outcome;overexpression;Pathogenesis;Pathologic;Pathway interactions;Peptide Hydrolases;pharmacologic;Phenotype;Phosphotransferases;Physiological;PIK3CG gene;Play;prevent;Prevention approach;Proteins;Publishing;Rattus;receptor;recombinase;Reporter;Reporting;Resistance;response;Role;sensor;Signal Pathway;Site;Substrate Specificity;System;Targeted Toxins;Therapeutic;Tissues;tool;Toxic effect;Toxin;tumor;Tumor Cell Line;Universities;uptake;Virulence;Visualization

PROJECT_TITLE: Pathophysiological Actions of Anthrax Virulence Determinants


NIH_SPENDING_CATS: Burden of Illness;Cystic Fibrosis;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

PI_NAMEs: PREVOTS, D. REBECCA  (contact)

PROJECT_TERMS: 12 year old;Acid Fast Bacillae Staining Method;Age;age group;aged;Agreement;Antibiotic Resistance;Antibiotics;Area;Asian population;Automobile Driving;Bacillus;beneficiary;Biological;Black Populations;burden of illness;Case/Control Studies;Centers for Disease Control and Prevention (U.S.);climatic factors;Clinical;clinical care;clinical epidemiology;clinically relevant;cohort;County;Cystic Fibrosis;cystic fibrosis patients;Data;Data Set;data sharing;Data Sources;Demographic Factors;Development;Diagnosis;Disease;Disinfectants;disorder risk;drinking water;Enrollment;Epidemiology;epidemiology study;Ethnic Origin;Ethnic Population;Future;Geography;Goals;ground water;High Prevalence;high risk population;Hispanic Populations;human old age (65+);ICD-9;improved;Incidence;Individual;Infection;infection risk;insight;interest;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Laboratories;Link;Logistic Regressions;Lung;Lung Diseases;Lung infections;Medicare;men;Metal exposure;Methods;Midwestern United States;Modeling;Molybdenum;Monitor;Municipalities;Mycobacterium abscessus;Mycobacterium avium;Mycobacterium avium Complex;Mycobacterium bovis;Mycobacterium gordonae;Mycobacterium Infections;Natural History;non-tuberculosis mycobacteria;non-tuberculous mycobacterial infection;novel therapeutics;Outcome;patient registry;Patients;Pattern;Persons;Population;population based;Population Study;Predisposition;Prevalence;Prevention strategy;Race;racial population;Regimen;Reporting;residence;respiratory;Risk;Risk Factors;Sampling;sex;sociodemographics;Source;Southeastern United States;Surface;System;Testing;Time;Trace metal;Treatment Effectiveness;trend;United States;United States Centers for Medicare and Medicaid Services;United States Environmental Protection Agency;United States National Institutes of Health;Vanadium;Water;Woman;Women's prevalence

PROJECT_TITLE: Epidemiology of Mycobacterial Infections


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Women's Health Research

PI_NAMEs: QUINN, THOMAS  (contact)

PROJECT_TERMS: 6 year old;Address;Adherence;Africa;Africa South of the Sahara;Age;age related;aged;AIDS prevention;Alcohol consumption;Anti-Retroviral Agents;antiretroviral therapy;Appointment;Area;Automobile Driving;Burkitt Lymphoma;care delivery;Caring;Client;Clinical;cohort;Cohort Studies;Communities;Continuity of Patient Care;Counseling;Couples;Data;dietary requirement;Disclosure;Eastern Africa;Eligibility Determination;Enrollment;Epidemic;epidemic response;Female Adolescents;flexibility;follow-up;Frequencies;Gender;General Population;genetic risk factor;girls;Goals;Herpesviridae;high risk;HIV;HIV anti-retroviral;HIV risk;HIV Seronegativity;immune activation;Immunologics;implementation barriers;improved;Incidence;Individual;Infection;infection burden;Injectable;Injections;interest;international center;Intervention;Investments;latent HIV reservoir;Malaria;male;male health;men;migration;Modeling;Monitor;Morbidity - disease rate;mortality;older men;Oral;Participant;person centered;Persons;Pharmaceutical Preparations;Phase;Phylogenetic Analysis;pill;Population;population based;Population Group;pre-exposure prophylaxis;Prevention;Prevention strategy;Privacy;programs;Prostitution;Public Health;Quality of Care;Reaction;Reporting;reproductive;Research;Resources;Rural;Rural Community;scale up;Schedule;Services;social stigma;Southern Africa;success;System;Testing;therapy adherence;tool;transmission process;Travel;treatment as prevention;Uganda;uptake;Viral;Viral Load result;viral rebound;Viremia;Woman

PROJECT_TITLE: International Center for Excellence in Research (ICER) in Uganda: Impact of ARVs


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

PI_NAMEs: KWON-CHUNG, KYUNG  (contact)

PROJECT_TERMS: ABCB1 gene;Acquired Immunodeficiency Syndrome;Aerobic Bacteria;Affect;Africa South of the Sahara;Aneuploidy;anti-fungal agents;Atmosphere;ATP-Binding Cassette Transporters;Azole resistance;Azoles;Behavior;Binding Proteins;Brain;Bypass;Carbon Dioxide;Categories;cell behavior;Cell Nucleus;Cells;Cellular Stress;Chemical Agents;Chromosome 1;Chromosome 4;chromosome missegregation;Chromosomes;Collaborations;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus;Cryptococcus gattii;Cryptococcus neoformans;Cytosine;DNA Sequence Rearrangement;Drug resistance;Endoplasmic Reticulum;Environment;Ergosterol;Etiology;Fluconazole;Fluconazole resistance;Flucytosine;Frequencies;fungus;gene function;Gene Mutation;Genes;Goals;Growth;Habitats;Histones;HIV Seropositivity;Human;Hypersensitivity;Hypoxia;Immunity;In Vitro;Individual;Infection;Intermediate resistance;Libraries;Link;London;Maintenance Therapy;man;Meningoencephalitis;minimal inhibitory concentration;Molecular;Monitor;Mus;mutant;Mutation;Neoadjuvant Therapy;neurotropic;Nitrogen;Nuclear;Nuclear Fusion;Organism;Oxygen;pathogen;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Phosphorylation;Polyenes;Predisposition;Pump;Reactive Nitrogen Species;Reactive Oxygen Species;Regulatory Element;Research Personnel;Resistance;resistance mechanism;Role;Serotyping;Signal Pathway;Sister;Source;Sterol Biosynthesis Pathway;Sterols;Stress;stress management;Substrate Specificity;System;T-Lymphocyte;Time;Treatment Failure;Universities;Virulence

PROJECT_TITLE: Stress Management of Cryptococcal Pathogens


NIH_SPENDING_CATS: Clinical Research;Eczema / Atopic Dermatitis;Infectious Diseases

PI_NAMEs: MYLES, IAN  (contact)

PROJECT_TERMS: Acute;adaptive immune response;adaptive immunity;Atopic Dermatitis;Autoimmunity;Back;Bacteria;Bacterial Infections;Chronic;Clinical Research;Development;Disease;Eczema;Formulation;Genetic;Goals;Host Defense;host-microbe interactions;Human;human pathogen;Hypersensitivity;Immune;Immune response;Immunity;Immunologics;improved;Infection;Innate Immune Response;interest;Knowledge;Licensing;Longevity;Lotion;Malignant Neoplasms;Mediating;mouse model;Mucous Membrane;Mus;Natural Immunity;Participant;Pathogenesis;pathogenic bacteria;Pathologic;Pathway interactions;Patients;Phase;placebo group;Placebos;prebiotics;Predisposition;response;Role;Shapes;Skin;Staphylococcus aureus;Symptoms;T cell differentiation;T memory cell;tool;vaccine efficacy

PROJECT_TITLE: Host Immunity Against Bacteria


PI_NAMEs: SHEVACH, ETHAN  (contact)

PROJECT_TERMS: Activated Natural Killer Cell;Adaptive Immune System;adaptive immunity;Amino Acids;Antigen-Presenting Cells;antigen-specific T cells;Antitumor Response;Area;Autoimmune Diseases;Binding;Binding Sites;Biological;Biological Assay;Biological Products;cancer therapy;CD8-Positive T-Lymphocytes;Cell Line;Cell Physiology;Cell Proliferation;Cells;checkpoint inhibition;Complex;Cooperative Research and Development Agreement;Cytolysis;Development;differential expression;effector T cell;Engineering;Equilibrium;Fab Immunoglobulins;Family;Globulins;Graft Rejection;Growth;HLA Antigens;HLA-A gene;Homeostasis;Human;humanized mouse;Hybridomas;IL2RA gene;Immune;Immune checkpoint inhibitor;Immune response;Immunize;immunodeficiency;Immunodeficient Mouse;Immunoglobulins;immunoregulation;In Vitro;in vivo;inhibitor;Innate Immune System;Interferon Type II;Interleukin-15;Interleukin-2;Killer Cells;Leukocytes;Light;Malignant Neoplasms;man;Measures;Mediating;Melanoma;member;Membrane;Memory;Monoclonal Antibodies;mouse model;Mus;Myeloid Cells;Natural Immunity;Natural Killer Cells;neoplastic cell;NK Cell Activation;novel therapeutic intervention;Pancreatic Adenocarcinoma;pathogen;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Pharmacologic Substance;Phenotype;Phosphorylation;Play;prevent;Prevention;Production;programs;Proliferating;Property;Reaction;receptor;reconstitution;Regulatory T-Lymphocyte;Resistance;Role;Signal Transduction;Stat5 protein;Structure;Suppressor-Effector T-Lymphocytes;Surface Antigens;T cell regulation;T-Cell Activation;T-Lymphocyte;Therapeutic Effect;Transgenes;Translating;tumor;Tumor Antigens;tumor growth;Tumor Immunity;tumor microenvironment

PROJECT_TITLE: Studies of Human T Regulatory Cells


PROJECT_TERMS: Benchmarking;Biological Assay;Communities;Culicidae;design;Development;epidemiology study;Failure;feeding;Future;Human;improved;Life Cycle Stages;Malaria;malaria transmission;malaria transmission-blocking vaccine;Malaria Vaccines;Measures;Microbiology;Modeling;Nature;Parasitemia;Parasites;Parasitic Diseases;Plasmodium;Population;Publishing;Skin;Standardization;success;Surveys;tool;transmission blocking;transmission process;transmission-blocking vaccine;vaccine candidate;vaccine trial;Vaccines

PROJECT_TITLE: Assays to Support Development of Malaria Transmission Blocking Vaccines


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Human Genome;Infectious Diseases;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: SU, HELEN  (contact)

PROJECT_TERMS: Apoptosis;Autoimmune;autoimmune lymphoproliferative syndrome;Autoimmunity;B-Lymphocytes;Bacterial Infections;Biochemical;Brain;Candidate Disease Gene;CASP8 gene;Cells;cellular longevity;Ceramides;Clinical;Common Variable Immunodeficiency;comparative genomic hybridization;CTLA4 haploinsufficiency;Defect;Development;Diagnosis;Disease;Endocrine;Epstein-Barr Virus Infections;Evaluation;Evans Syndrome;exome sequencing;experimental study;Genes;Genetic;genome sequencing;Genomics;GTP-Binding Proteins;Human;Human Herpesvirus 4;Hybridization Array;Hyper-IgE Syndrome;Hypersensitivity;Immune;Immune system;Immune System Diseases;immunodeficiency;immunoregulation;improved;In Vitro;Infection;Infiltration;Inflammation;influenzavirus;Inherited;Intake;Knowledge;Link;Liver diseases;lymphadenopathy;Lymphocyte;Lymphocyte Activation;Lymphoid;Lymphopenia;Magnesium;Molecular;Molecular Target;Mutation;Mycoses;Natural History;Natural Immunity;Neoplasms;NF-kappa B;optimal treatments;Organ;Pathogenesis;patient subsets;Patients;Play;Predisposition;prevent;Rare Diseases;Reporting;Research;Respiratory syncytial virus;respiratory virus;Rhinovirus;Role;Scientific Advances and Accomplishments;screening;senescence;Signaling Protein;skeletal;Stimulus;Syndrome;System;T cell anergy;T-Lymphocyte;Technology;Testing;Tissues;transcriptome sequencing;Variant;Virus Diseases;whole genome;Work

PROJECT_TITLE: Defining New Human Immunodeficiency and Immunodysregulation Disorders


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Infant Mortality;Infectious Diseases;Pediatric;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: LETO, THOMAS  (contact)

PROJECT_TERMS: Actins;Adaptive Immune System;Arthritis;Autoimmune Diseases;B-Lymphocytes;Bacterial Infections;Binding;Biological;Biological Models;Blood;Blood specimen;Case Study;Cells;Chronic;Chronic Granulomatous Disease;Clinical;Clinical Data;Clinical Management;cohort;Confocal Microscopy;Cytoskeleton;Defect;Dendritic Cells;Development;Disease;disease phenotype;Dominant-Negative Mutation;early onset;Enzymes;Exhibits;Family;Functional disorder;Generations;Genetic;genetic manipulation;genetic variant;Goals;Human;Hydrogen Peroxide;Immune System Diseases;Immunity;immunodeficiency;Immunoglobulins;Impairment;In Vitro;in vitro Assay;infancy;Inflammatory;Inflammatory Bowel Diseases;Inherited;insight;Leukocyte Adhesion Deficiency;Link;Location;Lower Respiratory Tract Infection;Lupus;Lymphocyte;Lymphopenia;Mediating;Membrane;migration;Molecular;mouse model;Multicenter Studies;mutant;Mutation;Myelogenous;NADP;NADPH Oxidase;Natural History;Neonatal;Neutropenia;neutrophil;novel;Nox enzyme;Oncogenic;Oxidases;Oxidation-Reduction;Oxidative Stress;Oxygen;Pathologic Processes;Patients;Predisposition;Process;Production;programs;Property;Proteins;Proto-Oncogene Proteins c-akt;Publishing;Reactive Oxygen Species;reconstitution;Regulation;Reporting;Research;Respiratory Burst;Role;Severe Combined Immunodeficiency;Severity of illness;Signal Transduction;Signaling Molecule;Superoxides;System;T-Lymphocyte;Testing;tumor microenvironment;Variant;Virus Diseases;Work

PROJECT_TITLE: Role of Reactive Oxygen Species in Lymphocyte Development and Function


NIH_SPENDING_CATS: Biotechnology;Climate-Related Exposures and Conditions;Clinical Research;Emerging Infectious Diseases;Genetics;Hematology;Immunization;Infectious Diseases;Malaria;Microbiome;Prevention;Rare Diseases;Sickle Cell Disease;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: LEHMANN, TOVI  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Adult;Affect;Affinity Chromatography;Africa;Africa South of the Sahara;African;Age;age group;alpha-Thalassemia;Altitude;Animals;Anopheles gambiae;Anopheles Genus;Antibodies;Antigens;Arboviruses;Area;arm;avian plasmodia;Avidity;Bacteria;beta Globin;Binding Sites;Biological Assay;Biology;Blood;Caring;Cells;Centers of Research Excellence;Characteristics;Child;climate change;Clinic;Clinical;Clinical Research;Clinical Trials;Collaborations;Collection;Communicable Diseases;Complex;Culicidae;Cutaneous Leishmaniasis;Dengue;Dengue Virus;Detection;Disease;Disease Outbreaks;disease transmission;Disease Vectors;Distant;DNA;DNA sequencing;Dryness;Ecology;efficacy study;Endothelium;Enrollment;enzootic;Epidemiology;epizootic;Female;filaria;forest;frontier;Functional disorder;Funding;Genetic;genetic variant;Genotype;Goals;ground water;Growth;gut microbiota;Hemoglobin;Hemoglobinopathies;Human;human monoclonal antibodies;immunogenic;Immunoglobulin G;Immunology;Individual;Infection;infection rate;Insecticide Resistance;Institutional Review Boards;international center;Intervention;Invaded;Investigation;Investments;iron deficiency;Knowledge;Laboratory Research;Leishmania;Length of Stay;Lesion;Malaria;malaria infection;malaria mosquito;malaria transmission;Malaria Vaccines;male;Mali;Manuscripts;Measures;Medical;Metagenomics;Methods;microbial community;microbiota;microbiota composition;migration;Molecular;Morbidity - disease rate;mortality;Movement;National Institute of Allergy and Infectious Disease;Natural History;Natural Selections;Nature;Nitric Oxide;novel;Observational Study;Parasites;Participant;pathogen;Pathology;Phlebotominae;Phlebotomus;Plasmodium;Plasmodium falciparum;polyclonal antibody;Preparation;Prevalence;Process;programs;Proteins;Protocols documentation;Rain;Reporting;Research;Research Personnel;Rift Valley Fever;Risk;Role;Route;Sampling;Science;Scientist;Seasons;Senegal;Serology;Severities;Sickle Cell;Sickle Cell Anemia;sickling;Signal Transduction;Site;Skin;skin microbiota;Source;Specificity;Specimen;Sporozoites;Structure;Surveillance Program;Swab;symptomatic improvement;Techniques;Technology;Testing;Time;tool;Training;transmission process;transmission-blocking vaccine;Travel;United States National Institutes of Health;Universities;Vaccination;vaccine candidate;vaccine-induced antibodies;Vaccines;Vascular Endothelium;Vascular System;vector;vector competence;vector mosquito;Vector-transmitted infectious disease;Virus;Visual System;volunteer;West Nile;Work;Zoonoses

PROJECT_TITLE: Mali International Center for Excellence in Research: Vectors and Hosts of Parasitic Infectious Diseases


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lymphatic Research;Lymphedema;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: NUTMAN, THOMAS  (contact)

PROJECT_TERMS: Acute;Affect;Area;burden of illness;Caring;Child;Clinical;Clinical Trials;Communicable Diseases;cost;Cost Savings;Data;Dentistry;Dipetalonema Infections;Disease;economic impact;effective intervention;Eosinophilic Esophagitis;Faculty;Filaria bancrofti;Filarial Elephantiases;Filariasis;Frequencies;Goals;Health;Hygiene;Immune;Infection;international center;Interruption;laboratory facility;Limb structure;Lymphedema;Mali;Medicine;Molecular;Monitor;neglected tropical diseases;novel diagnostics;novel strategies;novel therapeutic intervention;Onchocerciasis;Participant;Pathogenesis;Patients;Pharmacy facility;Physicians;Pilot Projects;Prevalence;programs;Quality of life;Research;Research Design;rural area;Schistosomiasis;Scientist;socioeconomics;transmission process;Universities

PROJECT_TITLE: Mali International Center for Excellence in Research: Filariasis


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Malaria;Neurosciences;Pediatric;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: PIERCE, SUSAN  (contact)

PROJECT_TERMS: Adult;Africa;African;antagonist;Anti-malarials;Antigens;arm;Authorization documentation;Blood brain barrier dysfunction;Blood Vessels;Brain;Brain Edema;Brain Stem;CD3 Antigens;CD8-Positive T-Lymphocytes;Cerebral Malaria;Cerebrovascular system;Cessation of life;Child;Childhood;Clinical;Clinical Protocols;Clinical Trials;co-infection;Communicable Diseases;Complication;Cross Presentation;Culicidae;Data;Development;Disease;Dose;Endothelium;Falciparum Malaria;Funding;Glutamine;Goals;Grant;hearing impairment;Hemorrhage;HIV;human disease;Immune;immune cell infiltrate;Immunology;Impaired cognition;Impairment;Infection;Inflammation;Institutional Review Boards;Knowledge;Life;Magnetic Resonance Imaging;Malaria;Malawi;Mechanics;medical schools;Molecular;Morbidity - disease rate;mortality;mouse model;National Institute of Allergy and Infectious Disease;Nature;Obstruction;Parasites;Pathology;Pattern;Pediatric Hospitals;Phase;Placebo Control;Plasmodium falciparum;Public Health;recruit;Research;Safety;safety study;safety testing;Senior Scientist;Side;Site;Syndrome;T cell therapy;Time;transmission process;Venous;Visual impairment

PROJECT_TITLE: Malaria immunology


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Diabetes;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Pediatric;Prevention;Rare Diseases;Tuberculosis;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Acute-Phase Proteins;Address;adipokines;adiponectin;Adult;Advocate;age group;Anthelmintics;Antigens;Antitubercular Agents;Area;Bilateral;Biochemical;Biological Markers;biomarker discovery;Biotechnology;Blood Glucose;burden of illness;C-Peptide;C3bi;CCL11 gene;CCL2 gene;Characteristics;chemokine;Child;Childhood;Clinical;clinical research site;co-infection;cohort;Collaborations;Communicable Diseases;comorbidity;Complement;Complement 1q;Complement 3b;Complement 4b;Complement 5a;Complement Activation;Complement Factor B;Complement Factor D;Complex;Country;COVID-19;COVID-19 vaccination;CSF3 gene;CXCL1 gene;CXCL10 gene;cyber infrastructure;cytokine;Dengue;Developing Countries;diabetes management;Diabetes Mellitus;Disease;drug-sensitive;EGF gene;Elderly;Emerging Communicable Diseases;Endemic Diseases;Enzyme-Linked Immunosorbent Assay;Epidemiology;Exhibits;Family;Female;FGF2 gene;Filariasis;Fostering;Future;Gelatinase B;genetic regulatory protein;Glucagon;Glycosylated Hemoglobin;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Growth Factor;Health;Healthcare;helminth infection;Helminths;Hemoglobin concentration result;HIV;Homeostasis;Hookworm Infections;Hookworms;Hospitals;IL17 gene;IL18 gene;IL8 gene;Immune;Immune response;Immune system;Immunologic Markers;Immunologics;Immunology;immunoregulation;improved;India;Individual;Infection;Inflammation;Inflammatory;insight;Institution;Insulin;Interferon alpha;Interferon Type II;Interleukin-1 alpha;Interleukin-1 beta;Interleukin-10;Interleukin-12;Interleukin-13;Interleukin-2;Interleukin-4;Interleukin-5;Interleukin-6;International;international center;Intervention Studies;Lectin;Link;Lung;Lung Diseases;lung lesion;Malaria;male;Malnutrition;Matrix Metalloproteinases;Medical Research;Metabolic Diseases;microbial;Morbidity - disease rate;mortality;Multisystem Inflammatory Syndrome in Children;National Institute of Allergy and Infectious Disease;Neutrophil Collagenase;Newly Diagnosed;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Obesity;Odds Ratio;Outcome;Pancreatic Hormones;Pathogenesis;Patient Care;Patient Recruitments;Patient-Focused Outcomes;Patients;Physicians;platelet-derived growth factor AB;Play;Population;Postdoctoral Fellow;predictive marker;Process;Profibrotic signal;programs;protective effect;Pulmonary Pathology;Pulmonary Tuberculosis;Regional Disease;Regulation;Research;Research Institute;Research Personnel;Resources;Risk;Role;Rural;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;Scientist;seropositive;Severities;Severity of illness;sex;Sex Differences;Site;Sputum;Strongyloides stercoralis;Strongyloidiasis;student mentoring;Thoracic Radiography;Tissues;TNF gene;Training;Transforming Growth Factor alpha;Treatment outcome;Tuberculosis;tuberculosis diagnostics;tuberculosis immunity;tuberculosis treatment;United States National Institutes of Health;Vaccination;vaccine immunogenicity;Vascular Endothelial Growth Factors;Virus;Virus Diseases;welfare;Work;working group

PROJECT_TITLE: India International Center for Excellence in Research


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Malaria;Pediatric;Prevention;Rare Diseases;Vector-Borne Diseases;Zika Virus

PI_NAMEs: YEK, CHRISTINA  (contact)

PROJECT_TERMS: 2019-nCoV;Acinetobacter;Acinetobacter baumannii;Acute;Adult;Aedes;Age Years;aged;Agriculture;Animal Husbandry;Animals;Antibodies;Antibody-Dependent Enhancement;Antigens;Antimicrobial Resistance;Arboviruses;betacoronavirus;Biological Assay;Biology;biomarker identification;Birds;Burkholderia pseudomallei;Cambodia;Cambodian;carbapenem resistant Enterobacterales;Categories;Cells;chikungunya;Chikungunya virus;Child;Chiroptera;Climate;Clinical;clinical center;Clinical Research;clinical sequencing;cohort;community transmission;Country;COVID-19 pandemic;cross reactivity;Culicidae;Data;Dengue;Dengue Infection;Dengue Virus;design;Detection;Development;diagnostic algorithm;diagnostic development;Disease;Disease Outbreaks;disorder risk;Distant;Drug resistance;Emerging infection;Environment;Enzyme-Linked Immunosorbent Assay;Epidemic;Epidemiology;Escherichia coli;Evolution;Exposure to;Extramural Activities;Fever;Flavivirus;follow-up;forest;Forestry;Genes;Genetic Markers;genomic biomarker;Genomics;Genotype;Geography;Goals;healthy volunteer;Helminths;Henipavirus;HIV;Home;Human;human disease;Humoral Immunities;Immune;Immunity;Immunoglobulin G;Immunology;Immunotherapy;Incidence;Infection;Infrastructure;International;international center;Intervention;Intramural Research;Laboratory Research;Leptospirosis;Low Prevalence;Malaria;man;Manuscripts;metagenomic sequencing;Microbiology;Molecular Weight;Monitor;national surveillance;Nature;Neutralization Tests;novel;observational cohort study;Organism;pandemic disease;Participant;pathogen;Pathogenesis;pathogenic bacteria;Patients;Pattern;Pediatric cohort;peri-urban;Persons;Phylogenetic Analysis;Pilot Projects;Plasmodium falciparum;Plasmodium knowlesi;Plasmodium vivax;Population;programs;Proteins;Publishing;rapid test;Recombinant Proteins;Reporting;Research;research clinical testing;Research Personnel;Research Priority;Rickettsia;Risk;Salivary;Salivary Glands;Salmonella;Sampling;Sanitation;Sarbecovirus;SARS-CoV-2 immunity;Scrub Typhus;Seasons;secondary infection;Seroprevalences;Serotyping;Specificity;Streptococcus suis;surveillance network;Surveys;System;Testing;transmission process;Tropical Medicine;Typhoid Fever;United States National Institutes of Health;vector;vector control;vector-borne;vector-borne pathogen;Vector-transmitted infectious disease;Viral;Viral Genome;virology;Virus;West Nile virus;Western Blotting;whole genome;Zika Virus;Zoonoses

PROJECT_TITLE: International Research in Cambodia: Tropical Medicine and Vector Research


NIH_SPENDING_CATS: Infectious Diseases

PI_NAMEs: MCBRIDE, ALISON  (contact)

PROJECT_TERMS: Acceleration;Amino Acid Sequence;bioinformatics resource;Clinical;Communities;Country;Databases;Detection;Diagnosis;Disease;Family;functional genomics;Genes;Genome;Genomics;Goals;Image;Information Resources;Link;National Institute of Allergy and Infectious Disease;Papillomavirus;protein structure;relational database;Research;Research Personnel;Resources;Sequence Alignment;tool;United States National Institutes of Health;Update;Viral;Viral Genome;Virus;Virus Diseases;Visualization;web app;web site

PROJECT_TITLE: Papillomavirus Bioinformatics Resource


NIH_SPENDING_CATS: Bioengineering;Infectious Diseases;Networking and Information Technology R&D (NITRD)

PI_NAMEs: MEIER-SCHELLERSHEIM, MARTIN  (contact)

PROJECT_TERMS: Address;Affect;Algorithms;Amino Acids;Antibodies;Behavior;Binding;Binding Sites;Biochemical;Biological;Biological Models;Biological Process;biophysical properties;cell behavior;Cell model;Cells;Cellular biology;Cellular Membrane;Cellular Morphology;Classification;Collaborations;Complex;Computational Biology;Computational Technique;Computer Models;Computer Simulation;Computer software;cross reactivity;cytokine;Cytokine Receptors;Data;Data Set;Databases;Development;Diffusion;Dose;Engineering;Formulation;Geometry;Goals;graphical user interface;Immune;Immune response;Immune signaling;Immune system;Immunologic Receptors;Immunology;improved;Individual;infectious disease model;information display;information organization;interactive visualization;intercellular communication;interest;Intervention;Intuition;Laboratories;Language;Ligands;Link;Macrophage;Mathematics;Measurement;Measures;Mediating;Membrane;Methods;model building;Modeling;Modernization;Modification;Molecular;Molecular Target;Morphology;Motion;Organ;particle;pathogen;Pathway interactions;Peptides;Persons;Phosphorylation;Phosphotransferases;Physiological;Process;Proteomics;Pythons;Reaction;receptor;recruit;Research;Resolution;response;Risk Reduction;Shapes;Signal Pathway;Signal Transduction;Signaling Molecule;simulation;simulation software;Specific qualifier value;Stimulus;Surface;System;Systems Biology;T-Cell Receptor;T-Lymphocyte;Techniques;Technology;Tertiary Protein Structure;Testing;Time;Tissues;Toll-like receptors;tool;transcription factor;Translating;Translations;Whole Organism;Work

PROJECT_TITLE: Computational Biology in Systems Immunology and Infectious Disease Modeling


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Patient Safety

PI_NAMEs: DELEO, FRANK  (contact)

PROJECT_TERMS: Antibiotic Resistance;Area;Bacteria;Biology;Blood Circulation;Development;Diagnostic;Disease;Goals;healthcare-associated infections;human disease;Infection;Innate Immune Response;Lower Respiratory Tract Infection;methicillin resistant Staphylococcus aureus;Modeling;Multi-Drug Resistance;neutrophil;pathogen;Pathogenesis;pathogenic bacteria;Predisposition;prophylactic;Research;Skin Tissue;soft tissue;Staphylococcus aureus;Staphylococcus aureus infection;Testing;United States;Vancomycin;Virulence

PROJECT_TITLE: Mechanisms of Staphylococcus aureus virulence


NIH_SPENDING_CATS: Complementary and Integrative Health;Infectious Diseases;Microbiome

PI_NAMEs: OTTO, MICHAEL  (contact)

PROJECT_TITLE: Role of the human microbiota and probiotics


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

PI_NAMEs: BARRY, CLIFTON  (contact)

PROJECT_TERMS: Aminoglycosides;Antitubercular Agents;Applied Research;Area;arm;Award;bactericide;Biological Markers;Cause of Death;Characteristics;China;Chinese;Classification;Clinical;clinical candidate;clinical development;clinical diagnostics;Clinical Research;Clinical Trials;Collaborations;Conduct Clinical Trials;COVID-19 complications;COVID-19 pandemic;Cross-Sectional Studies;cytokine;Data;Data Analyses;Developing Countries;Diagnostic tests;Diagnostics Research;Disease;disease diagnosis;disorder risk;drug candidate;Drug Combinations;Drug resistance;Drug resistant Mycobacteria Tuberculosis;drug testing;drug-sensitive;effective therapy;Enrollment;European;Extreme drug resistant tuberculosis;Failure;Fluoroquinolones;follow-up;Foundations;Funding;Future;Goals;Immunologic Markers;improved;Infectious Agent;International;Intervention;Isoniazid resistance;Journals;Lesion;Lung;Manuscripts;Measurement;Medical;medication compliance;Medicine;Meropenem;Methodology;Methods;Microbiology;Molecular;Monobactams;Multidrug-Resistant Tuberculosis;Mutation;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;Natural Sciences;New England;novel;novel diagnostics;novel therapeutics;Participant;Patients;Pattern;PET/CT scan;Pharmaceutical Preparations;Phase;prospective;Protocols documentation;Province;Public Health;Publishing;radiological imaging;Radiology Specialty;rate of change;Regimen;Relapse;Reporting;Research;Research Personnel;Residual state;Resource-limited setting;Resources;Risk;Sampling;Sampling Studies;Science;secondary analysis;South Africa;South African;South Carolina;South Korea;Sputum;standard care;success;Technology;Testing;Thoracic Radiography;Translational Research;treatment duration;Treatment Protocols;treatment response;treatment strategy;Tuberculosis;tuberculosis chemotherapy;Tuberculosis diagnosis;tuberculosis drugs;tuberculosis treatment;United States National Institutes of Health;Universities;week trial

PROJECT_TITLE: International Tuberculosis Clinical Research


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Hematology;Human Genome;Rare Diseases

PI_NAMEs: DRUEY, KIRK M (contact)

PROJECT_TERMS: Actins;Acute;Address;Adherens Junction;Adult;Alleles;Anaphylaxis;anasarca;angiogenesis;Angiogenic Proteins;Angioneurotic Edema;Angiopoietin-2;Antigen Targeting;arginine methyl ester;attenuation;Biological;Biological Assay;biomedical referral center;Blood;Blood capillaries;Blood Cells;Blood Vessels;cadherin 5;Capillary Leak Syndrome;CCL2 gene;chemotherapy;Child;clinical center;Clinical Protocols;cohort;CXCL10 gene;cytokine;Death Rate;Defect;density;Diagnosis;Disease;disease model;Disease remission;DNA sequencing;Edema;Endothelial Cells;Endothelial Growth Factors;Endothelium;Etiology;Event;exome sequencing;experience;Extravasation;Flare;Functional disorder;Genes;Genetic;genetic association;genome sequencing;genome-wide;Goals;Growth and Development function;Hematopoietic;Histamine;Human;Hypotension;Hypotensives;Hypovolemia;Hypovolemics;Immune;Immunoglobulin G;Immunoglobulins;immunoregulation;Inflammation Mediators;Inflammatory;influenza infection;insight;Interleukin-6;Intravenous Immunoglobulins;Link;Liquid substance;Literature;macromolecule;Mediator;Medical;Modeling;Monoclonal Antibodies;Monoclonal Gammapathies;Monoclonal gammopathy of uncertain significance;Morbidity - disease rate;mortality;mouse model;Multiple Myeloma;Mutation;Nature;NOS3 gene;novel therapeutic intervention;Odds Ratio;Oliguria;Paraproteins;Parents;Pathogenesis;Patient Admission;Patients;Penetrance;Permeability;Plasma;Plasma Cells;Plasmacytic Leukemia;Polymorphism Analysis;Population;Predisposition;premalignant;Process;Property;Protein Array;Protein phosphatase;Proteins;Proteome;Protocols documentation;Rare Diseases;Receptor Protein-Tyrosine Kinases;Reporting;Research;response;RNA;Role;Sample Size;Sepsis;Serum;Shock;Signs and Symptoms;Single Nucleotide Polymorphism;Single Nucleotide Polymorphism Map;SJL/J Mouse;solute;Source;specific biomarkers;Stimulus;Stress Fibers;stressor;Susceptibility Gene;Symptoms;Syndrome;Testing;Therapeutic;TIE-2 Receptor;Tissues;transcriptome;United States National Institutes of Health;Variant;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Vascular Endothelium;whole genome;Xenograft Model

PROJECT_TITLE: Studies in the Pathogenesis of Systemic Capillary Leak Syndrome


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome

PI_NAMEs: NITA-LAZAR, ALEKSANDRA  (contact)

PROJECT_TERMS: adaptive immune response;Adipose tissue;ADP ribosylation;analog;Antibiotic Resistance;Antibiotic Therapy;Autoimmune Diseases;Biological;Biological Assay;Biopsy;Cell Line;Cell Physiology;cell type;Cells;Child;chronic inflammatory disease;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;Computational Biology;Computer Models;CRISPR/Cas technology;cytokine;Data;Data Correlations;Data Set;design;Diet;dietary;Disease;Disease Progression;Distal part of ileum;dosage;Elements;Endotoxins;Enzyme-Linked Immunosorbent Assay;Eosinophilic Esophagitis;Esophagus;Event;exhaustion;experimental study;Exposure to;Family;Flow Cytometry;follow-up;Gastrointestinal tract structure;Gene Expression;Genes;Germ-Free;Goals;gut bacteria;Homologous Gene;Host Defense;host-microbe interactions;Human;Hydrolase;ileum;Immune;Immune signaling;Immune system;Individual;Infection;Inflammasome;Inflammatory;Inflammatory Response;Innate Immune Response;insight;Integral Membrane Protein;interest;Interleukin-1 Receptors;Intervention;Kinetics;knock-down;Knock-out;Legionella pneumophila;Legionnaires' Disease;Ligands;Literature;Lupus;Lymphocyte Biology;Macrophage;Maryland;Mass Spectrum Analysis;Measures;Mediating;Meta-Analysis;Metabolic;Metabolic Diseases;Metabolism;microbiota;Mitochondria;MME gene;Modeling;Modification;Molecular;Molecular Profiling;molecular recognition;Mucous Membrane;Mus;mutant;Myelogenous;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;Nuclear;Nucleic Acids;Oregon;pathogen;pathogen exposure;Pathogenesis;Pathway interactions;Patients;Pattern;pharmacologic;Phosphoproteins;phosphoproteomics;Phosphorylation;Phosphotransferases;Population;Post-Translational Protein Processing;Process;Production;protein complex;protein expression;Protein Secretion;Proteins;Proteolysis;Proteome;Proteomics;Protocols documentation;receptor;Receptor Signaling;Regulation;Reporting;Resolution;response;RNA;RNA Interference;Role;Roseomonas;Sampling;sensor;Sepsis;Serine;Signal Pathway;Signal Transduction;Site;Site-Directed Mutagenesis;Small Interfering RNA;Staphylococcus aureus;Staphylococcus aureus infection;Structure;System;Thailand;therapy development;Threonine;Time;Tissues;TLR2 gene;TLR4 gene;TLR7 gene;TNF Receptor-Associated Factors;Toll-Like Receptor Pathway;Toll-like receptors;Toxoplasma;transcriptome;Tyrosine;Ubiquitination;Universities;Western Blotting

PROJECT_TITLE: Protein Modifications Involved in Cell Signaling


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: 3-Dimensional;Affinity;Behavior;Binding;Bioinformatics;Biological;Biological Assay;Biological Models;bone;Cell Line;Cells;chemokine;Chemotaxis;Collaborations;Complex;Computational Biology;Computer Models;Coupled;Data;Data Set;deamidation;design;differential expression;Exposure to;Freedom;G Protein-Coupled Receptor Signaling;Geometry;Immune signaling;Immune system;in silico;In Vitro;Inflammasome;insight;Label;Length;Ligands;Liquid Chromatography;Literature;Macrophage;Mammalian Cell;mass spectrometer;Mass Spectrum Analysis;mathematical model;Measurement;Measures;Mediating;Methodology;Methods;model building;Modeling;Modification;Molecular;Monitor;monocyte;Mouse Protein;Mus;Mutation;nano;network models;Osteoclasts;oxidation;pathogen;Pathway interactions;Peptides;Phosphorylated Peptide;predictive modeling;protein expression;protein structure;Proteins;Proteome;Proteomics;PubMed;Qi;Reaction;receptor;Receptor Signaling;response;RNA;Sampling;Set protein;Shotguns;Signal Pathway;Signal Transduction;Signaling Molecule;simulation;Site;software development;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;Stimulus;Study models;success;synthetic peptide;System;Testing;text searching;TLR4 gene;Transcript;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: Absolute Quantification of Molecular Representation and Interaction


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Dementia;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lewy Body Dementia;Neurodegenerative;Neurosciences;Prevention;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

PI_NAMEs: CAUGHEY, BYRON  (contact)

PROJECT_TERMS: Acceleration;Adopted;Affect;Age;alpha synuclein;ALS patients;Alzheimer's Disease;Alzheimer's disease brain;Amyloid;Amyloid Fibrils;Amyotrophic Lateral Sclerosis;Animals;Antibodies;Apical;Area;Astrocytes;Autopsy;Back;Binding;Biological Assay;Biological Markers;Blood Vessels;Bovine Spongiform Encephalopathy;Brain;brain control;brain tissue;C9ORF72;Cattle;Cells;Cerebellar Cortex;Cerebellum;Cerebrospinal Fluid;Cerebrum;cervid;Characteristics;chronic traumatic encephalopathy;Chronic Wasting Disease;Clinical;cofactor;cohort;Collaborations;conditional knockout;Cortical Cord;Creutzfeldt-Jakob Syndrome;Deacetylase;Dedications;Dementia with Lewy Bodies;Deposition;dermatome;Detection;detection assay;Development;Diagnosis;diagnostic value;Diamond;Disease;disorder control;Drainage procedure;Dryness;Ear;Early Diagnosis;Enzymes;Etiology;Exposure to;extracellular;Extracellular Matrix;Extracellular Space;familial amyotrophic lateral sclerosis;Frontotemporal Dementia;Gene Mutation;Genes;Genetic;Genetic Polymorphism;genetic testing;Growth;Head;Heparitin Sulfate;Human;illness length;In Vitro;Infection;Knock-in Mouse;Knockout Mice;Laboratories;Lewy Bodies;Lewy Body Dementia;Link;Measures;Methionine;Molecular Conformation;Monoclonal Antibodies;Motor Cortex;Mus;Mutation;Nerve Degeneration;neural;Neurodegenerative Disorders;Neurons;neuropathology;novel;Parietal Lobe;Parkinson Disease;Pathologic;Pathology;Patients;Persons;pharmacodynamic biomarker;Physiological;polymerization;Polymers;Prion Diseases;prion seeds;prion-like;Prions;Prognostic Marker;protein aggregation;protein misfolding;Protocols documentation;prototype;PrP;PrP gene;PrPSc Proteins;Recombinants;Role;Sampling;Scrapie;Sheep;Skin;Solid;Source;Specificity;Specimen;Spinal Cord;sporadic amyotrophic lateral sclerosis;Stainless Steel;Steel;Sterilization;Sulfate;sulfotransferase;sulfurtransferase;superoxide dismutase 1;Surface;Surgical Instruments;tau aggregation;tau function;tau Proteins;Tauopathies;Testing;therapeutic development;Time;Tissues;Transgenic Mice;Universities;validation studies;Valine

PROJECT_TITLE: Detection of Prions


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Brain Disorders;Dementia;Emerging Infectious Diseases;Infectious Diseases;Lewy Body Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Orphan Drug;Parkinson's Disease;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

PROJECT_TERMS: Address;alpha synuclein;Binding;Biological Assay;Catalytic Domain;cost;Dementia with Lewy Bodies;Development;Disease;drug discovery;effective therapy;Failure;Goals;inhibitor;Lead;Machine Learning;machine learning method;Multiple System Atrophy;Neurodegenerative Disorders;Parkinson Disease;Pathologic;Pharmaceutical Preparations;Prion Diseases;Process;Proliferating;protein aggregation;Reporting;small molecule inhibitor;Structure;Surface;synuclein;synucleinopathy;Testing;Therapeutic;Toxic effect;Universities

PROJECT_TITLE: Prion Disease Therapeutics


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Orphan Drug;Pneumonia and Influenza;Prevention;Rare Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: FELDMANN, HEINRICH  (contact)

PROJECT_TERMS: Alpha Virus;Andes Virus;Animal Model;Animals;Anti-viral Agents;Antigen Presentation;Area;Arenavirus;Avian Influenza;Avian Influenza A Virus;Biology;Breeding;Cattle;Cells;Chiroptera;Communicable Diseases;Containment;Coronavirus;COVID-19 pandemic;Crimean-Congo Hemorrhagic Fever Virus;Data;Diagnostic;Diagnostic tests;disease model;Disease Outbreaks;disease transmission;Domestic Fowls;drug repurposing;Ebola;Ebola Vaccines;Ebola virus;Ecology;efficacy testing;Emergency Situation;emerging virus;Encephalitis;Enterovirus;Enterovirus 68;epidemiology study;Evaluation;Family suidae;Ferrets;Filovirus;Flavivirus;Fostering;Functional disorder;Generations;Genome;Glycoproteins;Goat;Health;Heartland virus;Human;Immune;Immune response;Immunization;In Vitro;in vivo;Infection;Influenza A Virus, H5N1 Subtype;innovation;Intervention;Lassa virus;Learning;Licensing;Life Cycle Stages;Livestock;Mastomys;Mission;Modeling;Molecular;Monkeypox;Monoclonal Antibodies;Mus;Nanostructures;neglect;Nipah Virus;nonhuman primate;novel vaccines;Orthobunyavirus;Orthomyxoviridae;pathogen;Pathogenesis;pathogenic virus;Pathogenicity;Pathology;Pattern;Play;Prevention Measures;Prophylactic treatment;Public Health;Rattus;Recombinants;remdesivir;Replicon;Research;Research Activity;research clinical testing;research facility;Respiratory distress;response;reverse genetics;Ribavirin;RNA;RNA amplification;Rodent;Role;SARS-CoV-2 antibody;Severe Fever with Thrombocytopenia Syndrome Virus;Sheep;structured lipid;Sudan Ebola virus;System;Technology;Therapeutic;transmission process;Vaccination;vaccine candidate;vaccine development;vaccine platform;Vaccines;vector;vector vaccine;Vesicular stomatitis Indiana virus;Viral;Viral Hemorrhagic Fevers;Viral reservoir;Virus;Virus Diseases;Visit;wild bird;Work

PROJECT_TITLE: Viral Hemorrhagic Fevers: Disease Modeling and Transmission


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: CONNORS, MARK  (contact)

PROJECT_TERMS: Address;Antibodies;Antibody Binding Sites;Antibody Response;Antigen Presentation;Antigen-Presenting Cells;Antigens;B Cell Proliferation;B-Lymphocytes;Binding;CD28 gene;CD3 Antigens;CD4 Positive T Lymphocytes;CD40 Ligand;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cell Line;Cell Separation;Cells;Characteristics;Chronic;Clinical;clinical development;Clone Cells;cohort;Collaborations;Coupled;Cultured Cells;cytokine;Data;design;Development;Dose;egg;Epitopes;Exhibits;experience;Exposure to;Genetic;Glycoproteins;glycosylation;Goals;HIV;HIV envelope protein;HIV Infections;HIV vaccine;HIV-1;Human;human monoclonal antibodies;Immune response;Immunity;immunogenic;Immunoglobulin Genes;Immunoglobulins;Immunotherapy;Individual;Infection;Inflammation;Inflammatory;Interleukin-2;interleukin-21;Knowledge;lead candidate;Macaca mulatta;manufacturability;Mediating;member;Membrane;Membrane Glycoproteins;Memory B-Lymphocyte;Molecular Conformation;Monoclonal Antibodies;Mucous Membrane;neutralizing antibody;neutralizing monoclonal antibodies;novel;Nucleic Acids;Participant;patient response;Patient Selection;patient subsets;Patients;peripheral blood;Phenotype;preclinical development;Prophylactic treatment;recruit;Research;research and development;Research Personnel;Resistance;response;Route;Site;SIV;Specificity;Techniques;Testing;Therapeutic;therapy development;Time;Toll-like receptors;Vaccination;vaccine access;vaccine platform;Vaccine Production;Vaccine Research;Vaccinee;Vaccines;vector;Viral;Virus;Virus Diseases;virus testing;Work

PROJECT_TITLE: Mechanisms of Effective Humoral Immune Responses to HIV-1


NIH_SPENDING_CATS: Clinical Research;Food Allergies;Rare Diseases

PI_NAMEs: CARTER, MELODY C (contact)

PROJECT_TERMS: Adverse reactions;alpha-gal syndrome;Anaphylaxis;Antigens;Basophils;Biopsy;Bone Marrow;Bone Marrow Aspiration;Clinical;clinical center;clinical phenotype;cohort;Collaborations;Core Facility;Data;Diagnosis;Disease;Drug Hypersensitivity;Etiology;European;experience;Food;High Prevalence;Idiopathic anaphylaxis;Immunotherapy;Inherited;Inpatients;Insect Sting;Investigation;Legal patent;Manuscripts;mast cell;mastocytosis;Mediator;Mutation;Myelogenous;participant enrollment;Pathogenesis;Pathway interactions;Patient Admission;patient population;Patients;Pharmaceutical Preparations;pharmacologic;Prevalence;Procedures;Prospective Studies;Proto-Oncogene Protein c-kit;Protocols documentation;Reaction;Recurrence;Reporting;Risk;Safety;Serum;Severities;Syndrome;Systemic Mastocytosis;targeted treatment;trait;Tryptase;Uncertainty;United States National Institutes of Health;Validation;Venoms

PROJECT_TITLE: Pathogenesis and Treatment of Anaphylaxis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

PI_NAMEs: BOSIO, CATHARINE  (contact)

PROJECT_TERMS: Acellular Vaccines;Acute;adaptive immunity;Aerosols;Anti-Inflammatory Agents;Bacteria;Bacterial Infections;bioweapon;capsule;carbohydrate structure;Carbohydrates;cell killing;Cells;cytokine;Dangerousness;Data;Death Rate;Defect;Dendritic Cells;Dengue Virus;Development;Disease;Francisella;Francisella tularensis;Goals;Health;Human;Immune response;Immune system;Immunosuppression;Impairment;In Vitro;in vivo;Incubated;Individual;Infection;Infectious Agent;Inflammation;Inflammatory;Inflammatory Response;Inhalation;Invaded;Laboratories;Legal patent;Lipid Synthesis Pathway;Lipids;Liposomes;Macrophage;Mediating;Membrane;Metabolic;Metabolic Pathway;Metabolism;Microbe;Mus;mutant;Natural Immunity;novel;novel therapeutics;novel vaccines;O Antigens;pathogen;pathogenic bacteria;Pathogenicity;Play;Predisposition;prevent;programs;Proteins;Pulmonary tularemia;receptor;Research;response;Role;Route;Secondary to;Sentinel;Signal Pathway;Signaling Molecule;Stimulus;Structure;Surface;Symptoms;Testing;Therapeutic;Time;transmission process;Tularemia;United States;USSR;vector-borne;Virulence;Virulent;weapons

PROJECT_TITLE: Modulation of Human Cells by Virulent Francisella tularensis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Pediatric;Rare Diseases;Vector-Borne Diseases;Zika Virus

PI_NAMEs: PETERSON, KARIN  (contact)

PROJECT_TERMS: Address;Affect;Alpha Virus;Animal Model;Apoptosis;Apoptotic;Arboviruses;Blood;Blood - brain barrier anatomy;Bone Marrow;Brain;cell type;Cells;Central Nervous System;Childhood;Clinical;Disease;Disease Outcome;Elements;emerging pathogen;fetal;Fetus;Fibroblasts;Flavivirus;Functional disorder;genomic variation;Goals;Golgi Apparatus;Human;Immune;Immune response;In Vitro;in vivo;Infection;Infectious Skin Diseases;Inflammatory;Innate Immune Response;Jamestown Canyon virus;keratinocyte;La Crosse virus;Ligands;Mammals;Mediating;Modeling;monocyte;mosquito-borne;Mus;Muscle Cells;Neck;Nervous System;Nervous System Disorder;Neurons;Neuropathogenesis;novel;Pathogenesis;Pathway interactions;Phagocytes;Phenotype;Placenta;Population;receptor;recruit;response;Signal Transduction;Signs and Symptoms;Simplexvirus;Skin;Specificity;Tahyna virus;Technetium Tc 99m ciprofloxacin;Therapeutic;Time;Tissues;transmission process;United States;vector;Vertical Transmission;Viral;Viral Encephalitis;Viral Pathogenesis;viral transmission;Virus;Virus Diseases;virus-induced neurologic disease;Zika Virus;ZIKV infection

PROJECT_TITLE: Mechanisms of Viral Pathogenesis in the Central Nervous System


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Brain Disorders;Dementia;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

PI_NAMEs: PRIOLA, SUZETTE ALISE (contact)

PROJECT_TERMS: Affect;alpha synuclein;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;amyloid formation;Amyloid Proteins;Annual Reports;Biochemistry;Biological Assay;Biological Models;Bovine Spongiform Encephalopathy;Brain;Cell Physiology;cell type;Cells;Chronic Wasting Disease;Collaborations;Complex;Creutzfeldt-Jakob Syndrome;Data;Deer;Deposition;Diffuse;dimer;Disease;Environment;Equine mule;Exposure to;Familial Creutzfeldt-Jakob Disease;Human;Iatrogenesis;In Vitro;in vivo Model;Incidence;Individual;Infection;Infectious Agent;insight;instrument;interest;Journals;Laboratories;Manuscripts;Medical;misfolded protein;Modeling;Molecular;Molecular Chaperones;Monitor;mouse model;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Parkinson Disease;particle;Pathogenesis;Pathogenicity;Pathway interactions;Peptide Hydrolases;Persons;Physiological;Preparation;Prion Diseases;prion-like;Prions;Process;protein aggregation;protein misfolding;Proteins;PrP;PrP amyloid;PrP gene;PrPSc Proteins;Publications;Publishing;Research;Resistance;Science;Scrapie;Sheep;Structure;tau Proteins;Time;Transgenic Mice;uptake;Work

PROJECT_TITLE: Molecular Mechanisms of Prion Protein Amyloid Formation


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Human Genome;Immunotherapy;Infectious Diseases

PI_NAMEs: FRASER, IAIN  (contact)

PROJECT_TERMS: Acetylation;Address;Adopted;analytical method;ATAC-seq;Behavior;beta-Glucans;Bioinformatics;Biological;Biological Assay;Biology;biomaterial compatibility;Cell Line;Cell Lineage;Cell membrane;Cell Membrane Permeability;Cell model;Cell Survival;Cell Therapy;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chromatin;clinical center;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Computer software;Control Groups;Coronavirus;COVID-19;COVID-19 patient;CRISPR screen;CRISPR/Cas technology;cytokine;cytotoxic CD8 T cells;Data;Development;Devices;Dose;Doxycycline;Drug Delivery Systems;electric field;Electrochemistry;Electrodes;Electroporation;Enhancers;epigenetic memory;Exhibits;Face;FDA approved;Gene Expression Profile;gene function;Genes;Genetic Materials;Genetic Screening;Genome;genome editing;genome wide screen;genome-wide;Goals;Hematopoietic;Heterogeneity;histone modification;Human;Image;Immune;immune activation;Immune response;Immunity;Immunology;immunosuppressive macrophages;improved;In Vitro;Inflammatory;Inflammatory Response Pathway;Influenza;information processing;inhibitor;innate immune mechanisms;Innate Immune Response;insight;Interleukin-12;Knock-out;Lentivirus;Ligands;Macrophage;Mammalian Cell;Mediating;Membrane;Metabolic;Methodology;Methylation;microbial;Microfluidics;Modeling;Molecular;Mus;Natural Immunity;Nuclear;nucleic acid delivery;Nucleic Acids;Outcome;Output;Oxidation-Reduction;particle;pathogen;pathogenic bacteria;pathogenic virus;Pathogenicity;Patients;Peripheral Blood Mononuclear Cell;personalized medicine;Phosphotransferases;Physiologic pulse;Poison;Polymers;Positioning Attribute;progenitor;programs;promoter;Property;Protocols documentation;Reaction;Reporter;Research;Research Personnel;Resistance;response;Rest;RNA Interference;RNA interference screen;Running;SARS-CoV-2 variant;screening;Screening Result;Secondary to;small molecule;Statistical Data Interpretation;Stimulus;Surface;System;systemic toxicity;T cell response;Technology;TNF gene;tool;Toxic effect;Training;transduction efficiency;Transfection;tumor;tumor microenvironment;United States National Institutes of Health;Up-Regulation;Validation;Variant;Viral;Virus Diseases;voltage;Work

PROJECT_TITLE: RNAi Screening in Hematopoietic Cells


PROJECT_TERMS: Acids;Acute;American;Antibiotic Therapy;Antibiotics;Arachidonic Acids;Attenuated;Bacteremia;Bacteria;Bacterial DNA;Bacterial Infections;bactericide;Biochemical;Biosensor;C-terminal;Calcium;Caspase;Categories;cell behavior;Cell model;Cells;Chemicals;chemotherapy;Clinical;clinically relevant;combinatorial;Communicable Diseases;Complex;Coupled;cytokine;Cytosol;Data;Data Set;Development;Disease;DNA;Event;Exposure to;Fasting;Fatty Acids;Gene Expression Profiling;Genes;Genetic;genetic approach;Genetic Transcription;Goals;Growth;Human;Immune;Immune response;Immune signaling;Immune system;Immunologics;Individual;Infection;Infection Control;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Innate Immune Response;insight;Intervention;Investigation;Laboratories;Life Style;Ligands;Literature;Macrophage;MAP3K7 gene;MAPK8 gene;MAPK9 gene;Mediating;Microbe;microbial;Mitochondria;Mitogen-Activated Protein Kinases;Modeling;Modern Medicine;Modernization;mouse model;Mus;N-terminal;Non-Steroidal Anti-Inflammatory Agents;novel;Nuclear;Operative Surgical Procedures;Outcome;Output;p38 Mitogen Activated Protein Kinase;Palmitic Acids;pathogen;Pathogenicity;Pathway interactions;Pattern recognition receptor;Pharmaceutical Preparations;pharmacologic;Pharmacy facility;Phosphorylation;Phosphotransferases;Post-Translational Protein Processing;Protein translocation;Reactive Oxygen Species;Regulation;Reporter;Reporting;Research;response;Role;Saturated Fatty Acids;screening;Second Messenger Systems;Sepsis;Signal Pathway;Signal Transduction;Sterility;Stimulant;Stimulus;Stress;survival outcome;Systems Biology;Technology;Therapeutic Intervention;Time;Tissues;Transplantation;Unsaturated Fatty Acids;Work;Xanthine Oxidase

PROJECT_TITLE: Analysis of Innate Immune Signaling Networks


PI_NAMEs: BELKAID, YASMINE  (contact)

PROJECT_TITLE: Role of the microbiota in immunity


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Maternal Health;Pediatric;Pregnancy;Women's Health Research

PI_NAMEs: LONG, ERIC O (contact)

PROJECT_TERMS: Agonist;Allogenic;Amino Acids;antimicrobial;Binding;CD94 Antigen;Cell Separation;cell type;Cells;Cysteine;disulfide bond;Disulfides;early pregnancy;Endosomes;fetal;Fetal Development;Fetal Tissues;Fetus;Gatekeeping;Genes;genetic association;genetic signature;Genetic Transcription;Histocompatibility Antigens Class I;HLA G antigen;Impairment;Interferons;Invaded;Isomerase;Killer Cells;Ligand Binding;Mass Spectrum Analysis;maternal immune system;Maternal-Fetal Exchange;Molecular;Monoclonal Antibodies;Mutagenesis;mutant;Natural Killer Cells;NF-kappa B;NK Cell Activation;Nuclear Translocation;Oxidation-Reduction;Phenotype;Phosphorylation;Placenta;Placentation;Pre-Eclampsia;Pregnancy;programs;Protein Disulfide Isomerase;Protein Inhibition;receptor;Regulation;Reporter;response;Risk;Role;senescence;Signal Transduction;single-cell RNA sequencing;Structure;Sulfhydryl Compounds;Tissues;transcription factor USF;Transfection;trophoblast;Uterus;Vascular remodeling

PROJECT_TITLE: Natural Killer Cells in Pregnancy


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Hematology;Infectious Diseases;Microbiome

PI_NAMEs: SERETI, IRINI  (contact)

PROJECT_TERMS: Acute;Affect;Africa;Age;Aging;Antibodies;antiretroviral therapy;Autoantibodies;Autoimmune;belimumab;Binding;Biological Markers;biomarker validation;Blood Coagulation Disorders;Body mass index;C-reactive protein;Cardiovascular Diseases;Case Series;CD4 Lymphocyte Count;CD4 Positive T Lymphocytes;Cell Count;Cell Survival;Cells;Central America;Cessation of life;Chronic;Classification;Clinical;clinical predictors;Clinical Research;cohort;comorbidity;Complement;Complement Activation;Country;Cryptococcus;Cryptococcus neoformans;CXCL9 gene;cytokine;cytotoxicity;Defect;Depressed mood;Development;Disease;disease prognosis;Disease remission;dysbiosis;Etiology;Event;Feces;Ferritin;Fiber;Fibrin fragment D;fluorodeoxyglucose positron emission tomography;Glucose Transporter;glucose uptake;Glycolysis;Goals;gut microbiome;Hematopoiesis;Hematopoietic;Hemoglobin;Hemoglobin concentration result;Hemophagocytic Lymphohistiocytoses;Heterogeneity;High Prevalence;high risk;Histoplasma;Histoplasmosis;HIV;HIV diagnosis;HIV Infections;Human;humanized mouse;Immigration;Immune;immune reconstitution;Immune response;immunodeficiency;Immunosuppression;Impairment;improved;Incidence;Infection;Inflammasome;Inflammation;Inflammatory;interest;Interleukin-6;International;Intervention;Link;Lymphocyte;Lymphopenia;Malignant Neoplasms;Measurement;Measures;Mediating;Metabolism;microbial;microbiome;microbiome alteration;Minority;monocyte;Morbidity - disease rate;mortality;mortality risk;mouse model;Mucous Membrane;Mus;Mutation;mycobacterial;Mycobacterium avium Complex;Mycobacterium tuberculosis;new therapeutic target;novel therapeutic intervention;Opportunistic Infections;opportunistic pathogen;Participant;Pathogenesis;pathogenic fungus;pathogenic virus;Patients;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Phenotype;pilot trial;Plasma;Play;Population;Positron-Emission Tomography;Predisposition;Prevalence;Prognosis;Propionates;prospective;Reaction;reconstitution;Regulatory T-Lymphocyte;Reporting;Research;Residual state;response;restoration;Risk;Risk Factors;Role;Sampling;Seminal;Serum;Site;Somatic Mutation;Standardization;Symptoms;Syndrome;System;T-Cell Development;T-Lymphocyte;targeted treatment;Time;tool;uptake;Viral reservoir;Virus Diseases;Work

PROJECT_TITLE: Immunopathogenic Mechanisms of Human Immunodeficiency Virus (HIV) Disease


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Infectious Diseases;Pediatric;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: ROSENZWEIG, SERGIO  (contact)

PROJECT_TERMS: Adult;Antibodies;Antigens;Aspergillus;Autoimmune;Autoimmune Polyendocrinopathies;Autoimmunity;autosome;Blood;Candida;Candidiasis;Case Study;Childhood;Chromosomes;Chronic Mucocutaneous Candidiasis;Clinical;Clinical Immunology;Clinical Research;Communicable Diseases;Complex;congenital immunodeficiency;Consultations;curative treatments;cytokine;dectin 1;Dendritic Cells;design;diabetic;Diagnosis;Diagnostic;Disease;Dominant-Negative Mutation;Ectopic Expression;Enrollment;Evaluation;Exhibits;Failure;gain of function;gain of function mutation;Gene Expression;Gene Mutation;Genes;Genetic;Genetic Diseases;genetic immunotherapy;Genotype;Heterozygote;Human;Hypersensitivity;Hypersensitivity skin testing;Hypoparathyroidism;Immune system;immunodeficiency;Immunologic Deficiency Syndromes;Immunologics;Individual;infancy;Infection;Inflammatory;Inheritance Patterns;Inherited;Intercellular adhesion molecule 1;interest;Interferons;Investments;IRF4 gene;Laboratories;Longterm Follow-up;Medical;Microbiology;monocyte;Mucocutaneous Candidiasis;Mus;Mutation;Mycoses;Nature;novel;Online Mendelian Inheritance In Man;Paper;Pathway interactions;Patients;Phenotype;Pneumocystis carinii;Polyglandular Autoimmune Syndrome Type I;Predisposition;Prevalence;Production;programs;Protocols documentation;Publishing;Recommendation;Recurrence;Regulator Genes;response;Role;Sampling;Signal Pathway;Source;Specialist;STAT1 gene;Subjects Selections;Syndrome;TCF3 gene;Testing;Thymic epithelial cell;Tissues;trait;United States National Institutes of Health;volunteer

PROJECT_TITLE: Studies of Inherited Causes of Fungal Susceptability


PI_NAMEs: WILLIAMSON, PETER  (contact)

PROJECT_TERMS: Affect;Amphotericin;Amphotericin B;Antifungal Therapy;attributable mortality;Autoimmunity;Binding;Biological Markers;Blood;Blood - brain barrier anatomy;Brain;Candida;Candida albicans;candidemia;Cessation of life;Clinical Research;cohort;cost;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus;Cryptococcus neoformans;Disease;Endothelial Cells;Event;Flucytosine;fungus;Gene Expression;Genes;Genetic Transcription;HIV;Human;human disease;Hyphae;improved;Individual;Infection;Inflammatory Response;inhibitor;Intravenous;Invaded;Lung Diseases;Meningitis;Methods;migration;Modernization;Molecular;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;neuroinflammation;novel;novel therapeutics;Oral;Outcome;overexpression;pathogen;Pathway interactions;Patient-Focused Outcomes;Patients;preclinical study;Predisposition;Preparation;prevent;Process;Recombinants;Role;Safety;Series;Signal Pathway;Source;Stream;Surface;Syndrome;Therapeutic;Toxic effect;Transplant Recipients;Uganda;Validation;Viral;Virulence;Work

PROJECT_TITLE: Molecular Pathobiology of Cryptococcus neoformans


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases

PROJECT_TERMS: Acute;Adrenal Cortex Hormones;Amphotericin;Amphotericin B;Animal Model;anti-fungal agents;Antigens;attributable mortality;Autoantibodies;Autophagocytosis;bench to bedside;clinical efficacy;Clinical Treatment;cohort;Collaborations;Consumption;Convalescence;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus;Cryptococcus gattii;cytokine;Developing Countries;Disease;Evaluation;exome sequencing;Flucytosine;Funding;Genes;Genetic;granulocyte;Granulocyte-Macrophage Colony-Stimulating Factor;Human;Immunologics;Immunosuppressive Agents;improved;improved outcome;Individual;ineffective therapies;Inflammasome;Inflammatory Response;inhibitor;Intervention;Intravenous;Janus kinase;Laboratories;Lung Diseases;Macrophage;Magnetic Resonance Imaging;Meningitis;Meningoencephalitis;Methods;Monitor;monocyte;mortality;mouse model;Mutation;Mycoses;nano-string;novel;novel therapeutics;Oral;pathogen;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Physiologic pulse;Play;preclinical study;preclinical trial;Predisposition;Preparation;Protocols documentation;recruit;Refractory;Regimen;Regulatory Pathway;Reporting;Risk Factors;Role;Route;Safety;Signal Transduction;STAT protein;Steroids;Susceptibility Gene;Syndrome;Testing;Therapeutic;Therapeutic Trials;Time;tocilizumab;Toxic effect;Translating;Translational Research;Translations;Uganda;Virulence

PROJECT_TITLE: Translational Research: Host-Pathogen Interactions in Patient Fungal Diseases