NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: Project Narrative Acute Graft-versus-Host Disease (aGVHD) is a common and frequently lethal complication, occurring in >50% of allogeneic stem cell transplants, limiting survival and the success of a curative therapy for hematologic diseases. The proposed study will examine the underlying effects of Bromodomain and Extraterminal (BET) domain inhibition on T cell and dendritic cell immunobiology both in preclinical and clinical studies and assess synergy of dual BET/JAK1/2 inhibition for treatment of aGVHD. Our studies will determine the safety and feasibility of a novel therapy for steroid-refractory aGVHD and establish the biological rationale for single agent and combination therapy for future clinical studies.

PI_NAMEs: CHOE, HANNAH  (contact);RANGANATHAN, PARVATHI

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Acetylation;Acute Graft Versus Host Disease;Adrenal Cortex Hormones;Affect;Allogenic;BCL2 gene;Benzodiazepines;Biological;Biology;Bromodomain;Bromodomains and extra-terminal domain inhibitor;Calcineurin;CD80 gene;CD86 gene;Cell Cycle;Cell Physiology;Cell Survival;chromatin modification;Clinical;clinical efficacy;Clinical Research;Clinical Trials;combat;combinatorial;Combined Modality Therapy;Complication;Correlative Study;curative treatments;cytokine;Cytokine Receptors;cytotoxic CD8 T cells;Data;Death Rate;Dendritic Cells;design;Development;Disease;disease model;disorder prevention;Drug Kinetics;effective therapy;effector T cell;Epigenetic Process;epigenetic regulation;experimental study;FDA approved;Future;Gene Expression;Genes;Genetic Transcription;Goals;graft vs host disease;graft vs leukemia effect;Hematological Disease;Histone Acetylation;Homologous Transplantation;Human;IL17 gene;immune reconstitution;Immunobiology;improved;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;innovation;Interferon Type II;Interleukin-2;Interleukin-6;Investigation;JAK1 gene;Life;Mediating;Mediator;Molecular;mortality;mouse model;Mus;NF-kappa B;novel;novel therapeutics;Pathogenesis;Pathogenicity;Pathway interactions;Patient-Focused Outcomes;Patients;Phase;Phenotype;pre-clinical;Pre-Clinical Model;pre-clinical research;preclinical study;prevent;Prophylactic treatment;Proteins;Quality of life;Reader;Refractory;Regulatory T-Lymphocyte;Research;response;Risk;Safety;safety and feasibility;scaffold;Severity of illness;small molecule inhibitor;Stem cell transplant;Steroid therapy;Steroids;Structure;success;synergism;T cell differentiation;T cell response;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Tissues;TNF gene;TNFRSF5 gene;TNFSF5 gene;Toxic effect;Transcriptional Regulation;Translating;translational approach;Transplant Recipients;treatment duration;treatment response

PROJECT_TITLE: Targeting epigenetic regulation via Bromodomain and Extraterminal (BET) domain inhibition for treatment of GVHD

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Iron deficiency is the most common nutritional deficit worldwide and the #1 cause of anemia. The primary goal of this proposal is to define mechanisms by which iron modulates the activity of a family of RNA binding proteins which double as intracellular iron chaperones. This research program is highly relevant to public health because it will uncover basic mechanisms that become dysregulated with iron deficiency.

PI_NAMEs: ALEMAN, MARIA M. (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Address;Affinity;alpha Globin;Alternative Splicing;Anemia;Animals;Binding;Binding Proteins;Biological Assay;Biological Models;Biophysics;Cell Differentiation process;Cell Physiology;cell type;Cells;cofactor;Complex;Cord Blood Hematopoietic stem cells;Coupled;Data;Development;Disease;Erythrocytes;erythroid differentiation;Erythropoiesis;Event;Exhibits;experimental study;Family;Ferritin;Gene Expression;Gene Expression Regulation;Gene Proteins;Goals;Health;Hematopoietic;Hematopoietic stem cells;heme oxygenase-1;Hemoglobin;Human;in vitro Assay;in vivo;Ions;Iron;Iron Chelating Agents;Iron Chelation;iron deficiency;Life;Mediating;member;Messenger RNA;Metals;Molecular;Molecular Chaperones;mouse model;mRNA Precursor;Mus;Nutritional;overexpression;Pattern;peripheral blood;Poly C;Polyadenylation;Post-Transcriptional Regulation;posttranscriptional;Process;Production;progenitor;programs;Protein Biosynthesis;Protein Family;protein protein interaction;Public Health;Regulation;Regulatory Pathway;Research;response;Reticulocytes;RNA;RNA Binding;RNA Processing;RNA Sequences;RNA Splicing;RNA-Binding Proteins;RNA-Protein Interaction;Role;RUNX1 gene;Sampling;SLC11A2 gene;Specific qualifier value;Specificity;Spliced Genes;stem;stem cell model;stem cells;Tissues;Transcript;transcription factor;transcriptome;Work

PROJECT_TITLE: Iron-sensitive RNA regulation during erythropoiesis

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BIRMINGHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal fibrotic lung disease. Currently there is no effective therapy available to limit the progression of fibrosis for IPF patients. The knowledge gained in these studies can help us to achieve our long-term goal to develop novel therapy to limit lung fibrosis in IPF patients.

PI_NAMEs: DING, QIANG  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Adaptor Signaling Protein;Adhesions;Apoptosis;Apoptotic;BCAR1 gene;Biological Process;Cells;Cytoplasm;Data;Down-Regulation;effective therapy;Fibroblasts;fibrogenesis;Fibrosis;fibrotic lung disease;Focal Adhesion Kinase 1;Focal Adhesions;gain of function;genetic regulatory protein;Goals;Head;Human;idiopathic pulmonary fibrosis;Impairment;in vivo;indium-bleomycin;Induction of Apoptosis;Integrins;Joints;Knowledge;Link;Lung fibrogenesis;mechanotransduction;Mediating;Microfilaments;Microtubules;Molecular;Motility;mRNA Decay;Mus;Myofibroblast;novel;novel therapeutic intervention;novel therapeutics;Pathologic;Patients;Phenotype;Play;Publishing;Pulmonary Fibrosis;Regulation;repaired;Resistance;response;RNA Splicing;Rod;Role;S100A4 gene;Signal Transduction;Structure of parenchyma of lung;Talin;Tertiary Protein Structure;TGFB1 gene

PROJECT_TITLE: The Impaired FRNK in IPF

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Aging;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Environmental health has been recognized as one of the most pressing problems of our time because pollution and environmental degradation has an immense impact on human health, especially in developing countries. This program will build on existing strengths at the Icahn School of Medicine and at the National University of Costa Rica to improve opportunities for research and collaboration. The training program will have impacts at the individual, institutional, national and regional levels by building on evidence gathered from previous experiences in research training programs by both institutions.

PI_NAMEs: CLAUDIO, LUZ  (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Brain Drains;Cessation of life;Child;Collaborations;Communities;Costa Rica;Costa Rican;Country;design;Disease;Educational process of instructing;Ensure;Environmental Exposure;Environmental Health;Environmental Pollution;experience;Funding;global environment;Health;Health Professional;Health Resources;Individual;Institution;International;Intervention;Latin America;life span;low and middle-income countries;Malaria;Mentors;Mission;Occupational Health;Participant;Pollution;prevent;programs;Publications;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;Scholarship;Scientist;Short-Term Course;skills;Time;Training;Training Programs;Tuberculosis;underserved community;United States National Institutes of Health;Universities;Vulnerable Populations

PROJECT_TITLE: International Training in Environmental Health over the Lifespan


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Immunotherapy;Ovarian Cancer;Prostate Cancer;Rare Diseases;Urologic Diseases;Women's Health Research

ORG_CITY: QUEENS

ORG_DEPT: BIOLOGY

ORG_NAME: ST. JOHN'S UNIVERSITY

PHR: Public Health Relevance Statement The goal of this project is to identify mechanisms by which immune checkpoint programmed death ligand 1 (PD-L1) regulates mRNA homeostasis of anti-apoptotic genes. Immunotherapies targeting surface PD-L1 expression have shown impressive clinical results in many cancers, but only a fraction of patients achieve durable responses, highlighting our incomplete understanding of the mechanisms of PD-L1 functions. This project will advance our understanding of the immune-independent, intracellular PD-L1 functions by identifying mechanisms by which it regulates mRNA homeostasis, and may lead to the development of novel therapies that target PD-L1 anti-apoptotic functions in cancer cells.

PI_NAMEs: VANCUROVA, IVANA  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Acetylation;actinomycin;Affect;Apoptosis;Apoptotic;Binding;Biomedical Research;cancer cell;cancer therapy;Cell surface;Cell Surface Proteins;Cells;chemokine;chromatin immunoprecipitation;Clinical;cytokine;Data;Development;DNA Binding;Environment;EP300 gene;experimental study;Genes;Genetic Transcription;Goals;histone acetyltransferase;Homeostasis;IL8 gene;Immune;immune checkpoint;immune checkpoint blockade;Immune response;Immunotherapy;in vivo;Inflammatory;Interferon Type II;Label;Learning;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Messenger RNA;Metabolic;mRNA Stability;mRNA Transcript Degradation;new therapeutic target;Nuclear Translocation;Outcome;Ovarian Stimulations;p65;Patients;PC3 cell line;programmed cell death ligand 1;promoter;prostate cancer cell;Proto-Oncogenes;public health relevance;radiation response;Radiation therapy;recruit;Regulation;Research;response;RNA;RNA analysis;RNA Polymerase II;RNA-Binding Proteins;SKOV3 cells;Surface;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Thiouridine;undergraduate research experience;Underrepresented Students;Universities

PROJECT_TITLE: Regulation of mRNA homeostasis by PD-L1


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Mental Health;Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Sexual and gender minority (SGM) youth in the United States are disproportionately affected by HIV. As HIV vaccines are in development, understanding biomedical HIV prevention concerns and misinformation among SGM youth can inform messaging interventions that proactively address such issues and increase awareness, intentions, and uptake. This proposal aims to develop youth-centered video messages that preemptively debunk misinformation regarding multiple biomedical HIV prevention methods (e.g., vaccines, PrEP) and to test them in an online randomized trial versus an information only control (e.g., CDC consumer-oriented information about vaccines and PrEP) on outcomes such as vaccine knowledge, intentions, and attitudes.

PI_NAMEs: HILL, BRANDON J;MACAPAGAL, KATHRYN ROSE (contact);WALTER, NATHAN

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Accounting;Address;Adolescent;Adolescent and Young Adult;adolescent HIV prevention;Adult;Affect;Age;age group;AIDS prevention;Area;Attitude;Awareness;Behavior;behavior change;Behavioral;Belief;Bisexual;Black, Indigenous, People of Color;boys;burden of illness;Chicago;Clinic;Clinical;Communities;condoms;COVID-19 pandemic;COVID-19 vaccine;design;Development;Education;Effectiveness;effectiveness testing;effectiveness/implementation design;Ensure;Epidemic;Exposure to;Face;Feedback;Focus Groups;Fostering;Friends;Future;Gays;gender minority youth;girls;Health;health communication;HIV;HIV vaccine;HIV/STD;Human Papilloma Virus Vaccine;Hybrids;implementation intervention;improved;Industry;Infection;Injectable;insight;Intervention;Interview;Knowledge;Media Campaign;Medical;Methods;Misinformation;Modeling;Motivation;novel;Oral;Outcome;Participant;peer;Perception;Persons;phase I trial;post intervention;pre-exposure prophylaxis;Predisposition;preference;Prevention;Prevention approach;Prevention strategy;preventive intervention;Primary Prevention;Production;Proxy;Public Health;randomized trial;Randomized, Controlled Trials;recruit;Research;Safety;Sampling;Sexual and Gender Minorities;sexual minority youth;social media;social norm;social stigma;Source;Stream;success;Surveys;Teenagers;Testing;therapy development;Time;transgender;Trust;truvada;United States;uptake;vaccine acceptance;vaccine distribution;vaccine efficacy;vaccine refusal;Vaccines;Work;Youth

PROJECT_TITLE: Reducing HIV vaccine and prevention hesitancy among sexual and gender minority adolescents


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE The “Clinical High Risk” (CHR) for psychosis syndrome in young people represents an opportune window for early intervention to prevent the onset of psychosis and other disorders, and to forestall disability; however, clinical heterogeneity and the paucity of biomarkers have hampered the development of effective intervention. To address these challenges, working with NIMH and key stakeholders, we will harmonize and aggregate existing “legacy” CHR data, and guide and coordinate the collection of new data across a network of sites, to develop biomarker algorithms that can predict individual trajectories for diverse outcomes. This proposal leverages a multidisciplinary team with broad and CHR-specific experience in large-scale multisite and multimodal studies (including clinical trials), along with expertise in data type-specific processing, coordination, analysis, and computational analyses (e.g., machine and deep learning tools from artificial intelligence, and advanced statistical approaches), ethics, community outreach, and data dissemination, all of which will ensure the success of this project.

PI_NAMEs: KAHN, RENE S.;SHENTON, MARTHA E. (contact)

PROGRAM_OFFICER_NAME: GARCIA, SUZANNE TYDLACKA

PROJECT_TERMS: Address;Adolescent;adverse outcome;Affect;Algorithms;analytical tool;Anxiety Disorders;Artificial Intelligence;Attenuated;attenuated psychosis syndrome;Behavior;Big Data;bioinformatics infrastructure;Biological Markers;biomarker identification;biomarker validation;candidate identification;candidate marker;Child;Clinical;clinical heterogeneity;clinical high risk for psychosis;clinical predictive model;clinical risk;Clinical stratification;clinical subtypes;Clinical Trials;clinically relevant;cloud based;cohort;Collection;Common Data Element;Communities;Community Outreach;Computer Analysis;computer scientist;Computer software;computerized data processing;Data;data acquisition;Data Aggregation;Data Analyses;data archive;Data Collection;data dictionary;data dissemination;data harmonization;data infrastructure;data integration;data repository;Data Set;data tools;Databases;deep learning;demographics;design;Development;disability;Disease;Disease remission;Early identification;Early Intervention;effective intervention;Enrollment;Ensure;Ethics;Evaluation;experience;FAIR principles;flexibility;Follow-Up Studies;functional decline;Functional impairment;Funding;Future;Goals;Heterogeneity;high risk;high risk population;Human Resources;Impaired cognition;improved;inclusion criteria;Individual;Informatics;Infrastructure;innovation;Instruction;Intervention;Lead;Leadership;Longterm Follow-up;Machine Learning;Measures;meetings;member;Mental disorders;Meta-Analysis;Methods;Monitor;Moods;Motivation;multidisciplinary;multimodal data;multimodality;multiple data types;National Institute of Mental Health;Online Systems;Outcome;outcome prediction;Output;Perception;persistent symptom;Persons;prediction algorithm;predictive marker;prevent;Procedures;Process;prospective;Protocols documentation;Psychoses;psychosis risk;psychotic;psychotic symptoms;quality assurance;Quality Control;Recommendation;Recovery;recruit;Research;Research Personnel;research study;resilience;response;Risk;risk prediction;risk stratification;Safety;Sampling;Schizophrenia;schizophrenia risk;Secure;Site;Social Functioning;Standardization;Substance Use Disorder;success;Symptoms;Technology;therapy development;Thinking;Time;tool;Training;United States;Validation;Visualization software;working group

PROJECT_TITLE: Psychosis Risk Evaluation, Data Integration and Computational Technologies (PREDICT): Data Processing, Analysis, and Coordination Center


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE The nucleus accumbens is an essential hub in the reward system integrating cognitive, contextual, sensory and affective information into behavioral outcomes. The proposed work will test the hypothesis that feed forward microcircuits within the nucleus accumbens regulate reinforcement behavior and are hijacked by drugs of abuse. By defining circuits and synaptic mechanisms necessary for reward processing, the proposed research is relevant to the NIH and NIDA's mission that pertains to developing fundamental knowledge that will help reduce the burdens of addiction.

PI_NAMEs: GRUETER, BRAD ALAN (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Abstinence;Acute;addiction;Affect;Affective;AMPA Receptors;Automobile Driving;Behavior;Behavioral;behavioral outcome;cell type;Cells;Chemosensitization;Cocaine;Cognitive;combinatorial;Data;design;Development;Drug Exposure;drug of abuse;Drug Receptors;Electrophysiology (science);excitatory neuron;Excitatory Synapse;Exhibits;experience;Generations;glutamatergic signaling;Glutamates;Goals;Illicit Drugs;in vivo;inhibitor;innovation;Interneurons;Knowledge;Learning;Long-Term Depression;Mediating;Medical;Memory;Mission;Molecular;National Institute of Drug Abuse;Neurons;novel strategies;Nucleus Accumbens;Opsin;optogenetics;Organizational Productivity;Output;Parvalbumins;patch clamp;Pathology;Pharmaceutical Preparations;Pharmacology;prevent;Prevention;Property;Psychological reinforcement;recruit;reinforced behavior;Research;reward processing;Rewards;Role;Self Stimulation;Sensory;Specificity;Stimulus;Substance Use Disorder;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;System;Techniques;Testing;Thalamic structure;Transgenic Mice;translational impact;transmission process;United States National Institutes of Health;Work

PROJECT_TITLE: Parvalbumin interneurons regulate nucleus accumbens synapses and behavior

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Patient Safety

ORG_CITY: BALTIMORE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE We propose a program to establish novel EEG biomarkers and computational tools that will enable rapid and accurate diagnosis of epilepsy followed by a rapid path to an effective treatment. Such a program entails major advances in conceptual knowledge of how epileptic cortical networks behave and change during drug and stimulation treatment, gleaned from dynamic network models (DNMs). Our lab has pioneered derivation of novel EEG biomarkers for epileptogenicity from DNMs and is well positioned to address major pain points in the workflow of diagnosing and treating epilepsy.

PI_NAMEs: SARMA, SRIDEVI V. (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: accurate diagnosis;Address;alternative treatment;anti-epileptic agents;Biological Markers;Brain;burden of illness;Clinical;cohort;computerized tools;Derivation procedure;design;Devices;Diagnosis;Disease;drug efficacy;Drug resistance;effective therapy;Electric Stimulation Therapy;Electrical Stimulation of the Brain;Electroencephalography;Epilepsy;Excision;Family;FDA approved;Glean;Hospital Costs;improved;indexing;Knowledge;Length of Stay;Malignant Breast Neoplasm;Malignant neoplasm of lung;Measures;men;Nervous System Disorder;network models;novel;Operative Surgical Procedures;optimal treatments;Outcome;Pain;Pathologic;patient population;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Positioning Attribute;programs;Property;rapid diagnosis;Recurrence;Scalp structure;Seizures;side effect;social stigma;Source;stem;success;Technology;vagus nerve stimulation;Woman;Work

PROJECT_TITLE: EEG Biomarkers Derived from Dynamical Network Models Enable Rapid Paths to Accurate Diagnosis and Effective Treatment of Epilepsy


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: The Loneliness Pandemic began decades ago due to changes in social lifestyle, dramatically accelerated during the COVID-19 pandemic, and threatens to propagate in the future. Feeling lonely slowly kills people, by increasing chronic disorders, the risk for depression and for suicidal ideation; consistently, people with autism die much younger than the average population. We propose to investigate brain mechanisms for voluntarily engaging in positive social interactions, with the focus on oxytocin circuits, and with the aim of refining their therapeutic potential.

PI_NAMEs: CARCEA, IOANA  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Acceleration;Address;Adult;affiliative behavior;Amygdaloid structure;Animals;autism spectrum disorder;Automobile Driving;base;Behavior;Behavior Therapy;Behavioral;Behavioral Paradigm;Biological;Biology;Brain;Cells;Cessation of life;Child;Chronic Disease;Clinical Trials;computerized tools;COVID-19 pandemic;Cues;Data;design;Electrophysiology (science);environmental change;Ethology;experimental study;Feeling;Feeling suicidal;Female;Future;General Population;Genetic;global health;Goals;Grant;Habitats;Health;Hormones;Housing;Human;Hypothalamic structure;Impairment;Incentives;individuals with autism spectrum disorder;innovation;Investigation;Life Style;Loneliness;Longevity;mature animal;Mediating;Mental Depression;Mental Health;Modeling;Monitor;Mus;neural;neural circuit;Neurons;Neuropeptides;Neurosecretory Systems;novel;Optics;optogenetics;Output;Oxytocin;Oxytocin Receptor;pandemic disease;paraventricular nucleus;Pattern;Peripheral;Persons;Pharmaceutical Preparations;Play;Population;premature;prevent;Primates;Psychological reinforcement;pup;Research;response;Rewards;Risk;Role;Signal Transduction;social;Social Behavior;Social Conditions;social engagement;Social Interaction;Social isolation;Social outcome;Social Reinforcement;social structure;Stimulus;Stress;stress management;Structure;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;tool;Ventral Tegmental Area;Video Recording;Work

PROJECT_TITLE: Neuroendocrine circuits for engagement in affiliative social interactions

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: DE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative In this proposal, we seek to fit the Nr2f family of nuclear receptors into the role of differentiating the cranial neural crest into facial ectomesenchyme. We also study their conservation as an inhibitor of the Edn1 pathway later in vertebrate jaw formation. Completion of the proposed studies will deepen our understanding of cranial neural crest development, contributing to the pool of knowledge needed to develop non-surgical therapies for craniofacial birth defects.

PI_NAMEs: PAULDING, DAVID  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Ablation;Afferent Neurons;Alleles;Animal Model;Animals;apoAI regulatory protein-1;Automobile Driving;base;Biological Assay;Bone structure;Branchial arch structure;Cell Culture Techniques;Cell Death;Cell Proliferation;Cell Survival;Cells;Cephalic;Characteristics;Clinic;conditional mutant;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;Cre driver;Data;Development;differential expression;Dorsal;Embryo;experience;experimental study;Face;Family;Family member;Fellowship;Fishes;Future;Gene Family;Genes;Genetic;genetic variant;Histology;Human;Imaging Techniques;Immunofluorescence Immunologic;In Situ;Individual;inhibitor;insight;Jaw;Knock-out;Knowledge;Laboratories;loss of function;Mandible;Maxilla;member;Mesenchymal;migration;Mission;Modeling;Modernization;Molecular;Morphology;mouse genetics;Mus;mutant;Mutant Strains Mice;Mutation;National Institute of Dental and Craniofacial Research;Nature;Neural Crest;Neural Crest Cell;Nuclear Family;Nuclear Receptors;Pathway interactions;Patients;Pattern;Phenotype;Pigments;Play;Population;Publishing;Reporter;Role;Severities;skeletal;Skeleton;skills;Sorting;Specific qualifier value;Structure;System;Techniques;Testing;Thinking;Training;transcriptome sequencing;Transgenic Organisms;Variant;Work;Zebrafish

PROJECT_TITLE: Developmental roles of Nr2f1 and Nr2f2 in the vertebrate cranial neural crest

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Genetics

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative A number of viruses like hepatitis B virus (HPB), herpes simplex virus-1 (HSV-1) and Thogoto virus (THOV) target the general transcription factor TFIIB to regulate expression of viral-specific genes during pathogenicity. TFIIB has also been implicated in neurodegenerative disorder, spinocerebellar ataxia, and cardiac hypertrophy. With a view to understand functioning of TFIIB in a cell, our focus in this grant proposal is elucidation of the overall role of TFIIB in transcriptional regulation in the cell.

PI_NAMEs: ANSARI, ATHAR IMTIAZ (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Affect;Affinity;Applications Grants;Binding;Cell Proliferation;Cells;ChIP-seq;Complex;crosslink;Defect;Development;Disease;Distal;Eukaryota;Exhibits;experimental study;Gene Chips;Genes;Genetic Transcription;genome-wide;global run on sequencing;Goals;Heart Hypertrophy;Hepatitis B Virus;Herpesvirus 1;Investigation;Label;Laboratories;Mass Spectrum Analysis;Mediating;Molecular;Molecular Sieve Chromatography;Monitor;mutant;Names;Neurodegenerative Disorders;novel;Outcome;Pathogenicity;Peptide Initiation Factors;Peroxidases;Play;Prevalence;Process;promoter;protein protein interaction;Rattus;recruit;Role;Signal Transduction;Spinocerebellar Ataxias;System;termination factor;Testing;Thogoto virus;transcription factor;Transcription Factor TFIIB;Transcription Initiation;transcription termination;Transcriptional Regulation;Viral;Virus;Yeasts

PROJECT_TITLE: A new paradigm of general transcription factor TFIIB functionality in termination and promoter directionality

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative There is a critical need for oral healthcare among Medicare-eligible older adults, particularly those from underserved groups who experience oral health disparities. In this exploratory study, we will evaluate whether Medicare Advantage is facilitating equitable access to and utilization of oral health services among all demographics of enrollees. We will examine utilization of dental services by individual-level demographics, and identify community-level factors associated disparities to help inform future research and policies to achieve health equity in the Medicare population.

PI_NAMEs: WEATHERSPOON, DARIEN JEROME (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Accounting;African American;Age;Alternative Health;Behavioral Model;beneficiary;Black race;Characteristics;Chronic Disease;community intervention;community-level factor;Congresses;County;Data;demographics;Dental;Dental Care;Dental caries;Dentition;Disparity;economic disparity;edentulism;Eligibility Determination;Emergency Situation;Enrollment;Equity;ethnic minority;Ethnic Origin;experience;Face;Fee-for-Service Plans;Goals;Health;health care availability;health care service;health disparity;health equity;health plan;health service use;Health Services;Health trends;Healthcare;Hearing;High Prevalence;Hispanic;Hospitals;human old age (65+);improved;Income;Individual;Insurance;Intervention;Low income;low socioeconomic status;Marketing;Measures;Medical;Medicare;Minority;Mouth Diseases;novel;older adult;Oral health;Penetration;Periodontal Diseases;Personal Satisfaction;Pharmaceutical Preparations;Policies;Population;Predisposition;Preventive;Privatization;programs;Provider;Race;racial minority;Research;Retirement;satisfaction;socioeconomic disadvantage;Socioeconomic Status;Time;Tooth Loss;Tooth structure;Underserved Population;United States;Vision;Xerostomia

PROJECT_TITLE: Medicare Advantage and its Impact on Oral Health Equity among Older Adults

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: WORCESTER

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Narrative. This proposal seeks to elucidate how many cancers evade control by the immune system and thereby arise, progress, and become resistant to immunotherapy. The information gained from the proposed studies may lead to a better ability to predict and/or manipulate immune responses to tumors and ultimately aid in the immunotherapy of cancers.

PI_NAMEs: ROCK, KENNETH L (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Affect;Antigen Presentation;Basic Science;Bioinformatics;Biological Markers;cancer cell;cancer immunotherapy;Cancer Patient;cancer type;CD8-Positive T-Lymphocytes;Cells;Clinical;clinical predictors;Clinical Trials;cytokine;Data;Development;Epigenetic Process;epigenetic silencing;experimental study;Failure;FDA approved;Future;gain of function;Genetic Screening;Goals;Human;I-antigen;Immune;immune checkpoint blockade;immune clearance;Immune Evasion;Immune response;Immune system;immunogenic;Immunologic Surveillance;Immunotherapy;Impairment;improved;improved outcome;inhibitor;insight;IRF1 gene;Knockout Mice;loss of function;lung sarcoma;Malignant Neoplasms;Melanoma;Modeling;Molecular;Mus;mutant;Non-Small-Cell Lung Carcinoma;novel marker;novel therapeutics;Outcome;Patients;Peptides;Phenotype;pre-clinical;Process;Prognosis;programmed cell death ligand 1;Resistance;response;Role;Sarcoma;success;T cell response;T-Lymphocyte;Techniques;Testing;Therapeutic Agents;Therapeutic Uses;transcription factor;Translating;Translational Research;translational study;treatment and outcome;tumor;Tumor Escape;tumor progression;Viral;Virus

PROJECT_TITLE: Role of IRF2 in cancer immune evasion and immunotherapy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Nanotechnology;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Glioblastoma (GBM) is a highly aggressive, common malignant brain tumor that has a dismal prognosis of only 14 months despite aggressive standard treatment with radiation and temozolomide chemotherapy. Pharmacological ascorbate (IV vitamin C reaching ≈ 20 mM in plasma) is a novel, redox active iron dependent therapy that safely complements and potentially enhances GBM standard therapy. Therefore, due to the iron dependence of ascorbate, supplementation of pharmacological ascorbate with redox active iron (ferumoxytol) may further enhance the observed ascorbate response; this idea will be investigated in a phase 1 clinical trial.

PI_NAMEs: ALLEN, BRYAN  (contact);BUATTI, JOHN M

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: anti-cancer research;ascorbate;Ascorbic Acid;Astrocytes;Biochemical;Biological Markers;Brain;cancer cell;cancer imaging;cancer therapy;Cell Death;Chemistry;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Clinical;Clinical Trials;Data;Dependence;Deposition;Development;Diagnosis;DNA;DNA Damage;Dose;Dose Limiting;early phase clinical trial;Edema;efficacy evaluation;Electrons;Enrollment;Excision;FDA approved;ferumoxytol;first-in-human;Future;Glioblastoma;Glioma;Hour;Human;Hydrogen Peroxide;Hydroxyl Radical;Image;imaging biomarker;Imaging Techniques;improved;In Vitro;in vivo;Incidence;individual patient;Infusion procedures;innovation;Intervention;Intravenous infusion procedures;Ionizing radiation;Iron;Iron deficiency anemia;Iron Overload;iron oxide;iron oxide nanoparticle;iron supplementation;Lipids;liver injury;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Mediating;Metabolism;Metals;Methylation;MGMT gene;Molecular;mutational status;nanoparticle;No Evidence of Disease;non-invasive imaging;Non-Small-Cell Lung Carcinoma;Normal Cell;Normal tissue morphology;novel;novel strategies;Operative Surgical Procedures;Outcome;Ovarian;oxidation;Oxidation-Reduction;Oxygen;Patients;Pharmacologic Ascorbate;Phase;phase 2 study;Phase I Clinical Trials;phase I trial;Phase II Clinical Trials;phase II trial;Plasma;pre-clinical;Pre-Clinical Model;Predisposition;Prognosis;Prognostic Marker;Progression-Free Survivals;promoter;Proteins;Radiation;Radiation therapy;Reaction;Recurrence;Relaxation;Research;Research Project Grants;response;standard care;standard of care;Superoxides;superparamagnetism;Supplementation;synergism;T2 weighted imaging;temozolomide;Testing;Therapeutic;Time;Toxic effect;Treatment Protocols;treatment response;tumor;Tumor Tissue;United States

PROJECT_TITLE: Redox manipulation of iron to improve glioblastoma therapy: A phase 1 trial


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Heart Disease;Mental Health;Mental Illness;Patient Safety;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: This study will develop valid, actionable evidence about which drugs, when given together with second-generation antipsychotic agents, lead to an increased rate of out-of-hospital sudden cardiac arrest and ventricular arrhythmia. This evidence will improve the safety of drug therapy for millions of persons with mental health conditions who take second generation antipsychotic agents.

PI_NAMEs: HENNESSY, SEAN  (contact)

PROGRAM_OFFICER_NAME: DAVIS, BESHAUN JAMAAL

PROJECT_TERMS: Address;Adult;Adverse drug event;Adverse Drug Experience Report;Affect;Agitation;American;Antipsychotic Agents;Arrhythmia;Bipolar Disorder;Case Study;Cessation of life;Classification;Clozapine;common treatment;computerized;Controlled Study;Decision Support Systems;Dementia;Dose;Drug Combinations;Drug Interactions;Drug Kinetics;Drug usage;Etiology;evidence base;Fatigue;General Population;Generations;Health;Heart Arrest;High Prevalence;improved;Knowledge;Lead;Life;Life Expectancy;Longevity;Major Depressive Disorder;medication safety;Mental Health;Meta-Analysis;Nature;Newsletter;Odds Ratio;out-of-hospital cardiac arrest;Outcome;Patients;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacotherapy;Polypharmacy;Population;Population Research;Positioning Attribute;Prevalence;prevent;Psychoses;Psychotropic Drugs;Publishing;quetiapine;Research;Risk;Risk Factors;Safety;Sample Size;Schizophrenia;screening;Series;Source;Study of serum;support tools;systematic review;Torsades de Pointes;Translating;Validation;Ventricular Arrhythmia;webinar

PROJECT_TITLE: Drug Interactions Involving Second-generation Antipsychotic Agents Leading to Sudden Cardiac Arrest

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Burden of Illness;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Prevention;Rural Health;Social Determinants of Health

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE  There is mounting concern that the cardiovascular health of working-age adults (18 to 64 years) may be worsening in the United States. We will combine multiple sources of information, including national surveys from the Centers for Disease Control and Prevention, health care data from Medicaid and other insurers, and population-level death data to 1) characterize the epidemiology of cardiovascular risk factors, acute cardiovascular events (heart attack, heart failure, stroke), and cardiovascular deaths in low-income working-age adults on a national scale, 2) evaluate changes in health care coverage, access, and affordability, as well as cardiovascular morbidity and mortality, in the years that follow the Covid-19 pandemic, and 3) determine the potential effects of expanding the Medicare program on the cardiovascular health of this population. This research will provide critical information that informs public health and policy strategies to improve cardiovascular outcomes nationwide.

PI_NAMEs: WADHERA, RISHI KUMAR (contact)

PROGRAM_OFFICER_NAME: ANAYA, GABRIEL

PROJECT_TERMS: Acute;Adult;Age;Behavioral Risk Factor Surveillance System;Black race;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Caring;Cause of Death;Centers for Disease Control and Prevention (U.S.);Cessation of life;COVID-19 pandemic;Data;Data Set;Death Rate;Disease;econometrics;Eligibility Determination;Enrollment;epidemiologic data;Epidemiology;Equity;Evaluation;Event;experience;falls;Financial Hardship;Goals;Health;health care availability;health equity;health inequalities;Health Insurance;Health Policy;Health Services Accessibility;Healthcare;Heart failure;Hospitalization;improved;Incidence;Income;Inequity;insight;Insurance Carriers;Insurance Coverage;Interruption;large datasets;Left;Link;Low income;Low Income Population;Medicaid;Medical;Medicare;Methods;Morbidity - disease rate;mortality;Myocardial Infarction;National Health and Nutrition Examination Survey;Outcome;pandemic disease;pandemic impact;Patient Self-Report;Pattern;Policies;Policy Maker;Population;population health;Prevalence;programs;Public Health;public health insurance;Public Policy;Publishing;Quasi-experiment;Research;response;Risk Factors;Rural Community;screening;social health determinants;socioeconomics;Source;Stroke;Subgroup;Surveys;Time;Time Series Analysis;trend;Unemployment;United States;Vulnerable Populations;Work

PROJECT_TITLE: Cardiovascular Health of Low-Income Working-Age Adults in the US: Health Care Access, Policy, and the Pandemic


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Infectious Diseases;Microbiome

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative Bacterial communities react to environmental stressors, the presence of oxygen in the gut, for example, by changing their transcriptional landscapes, and these responses underlie microbiome-related disorders such as inflammatory bowel disease (IBD), and colorectal cancer (CRC). Although RNAseq has been used to profile community function to obtain dynamic functional information not captured by metagenomic DNA sequencing alone, RNAseq is unable to capture real-time dynamics due to the varying stability of RNA, requires additional steps to remove ribosomal RNA, and isoften insensitive to short non-coding or modified RNA. We propose the development of Precision Run-On and SEQuencing (PRO-seq) as a promising method to capture transcriptional dynamics in cultured prokaryotes and in complex microbial communities, such as the human microbiome.

PI_NAMEs: BRITO, ILANA LAUREN (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Activities of Daily Living;Acute;Address;Adopted;Antibiotic Resistance;Antibiotics;Antibodies;Bacteria;bacterial community;Bacterial Genome;Base Pairing;Benchmarking;biological adaptation to stress;Cells;Chemistry;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Colorectal Cancer;Communities;Complex;computational suite;computerized tools;cost;cost effective;Cytolysis;Data;Data Set;Development;Diet;Disease;diverse data;DNA Damage;DNA sequencing;DNA-Directed RNA Polymerase;Environment;environmental stressor;Escherichia coli;Eukaryota;Excision;Exercise;experimental study;feasibility testing;Fusobacterium nucleatum;Gene Expression Profile;genetic manipulation;Genetic Transcription;Genus Vanilla;Goals;Growth;Health;Heat-Shock Response;Homeostasis;Human;Human Microbiome;human microbiota;Immunoprecipitation;improved;Inflammatory;Inflammatory Bowel Diseases;insight;Laboratories;Laboratory culture;Libraries;Maps;Metabolic;metagenomic sequencing;Metagenomics;Methods;Microbe;microbial;microbial community;microbiome;microbiome sequencing;Modification;Noise;Operon;Organism;Output;Oxygen;pathogen;Pathway interactions;Periodontal Diseases;polymerization;Polymers;Positioning Attribute;posttranscriptional;Precision Run-On Sequencing;Prokaryotic Cells;Protocols documentation;Proxy;quorum sensing;Reaction;Regulation;Research Personnel;resilience;resistance gene;Resolution;response;Ribosomal RNA;RNA;RNA Decay;RNA Stability;Role;Sampling;Shotgun Sequencing;Signal Transduction;Site;Stimulus;Stress;stressor;Structure;success;Taxonomy;Technology;Testing;Time;tool;Transcript;Transcription Elongation;Transcription Initiation;Transcription Initiation Site;Transcriptional Regulation;transcriptome sequencing;transcriptomics;tripolyphosphate;Untranslated RNA;Virulence Factors;Xenobiotics

PROJECT_TITLE: High-Resolution Mapping of Bacterial Transcriptional Responses in Human-Associated Microbiota

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Natural Products;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Rehabilitation

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: TITLE: CAFFEINE AND POSTOPERATIVE NEUROCOGNITIVE RECOVERY PUBLIC HEALTH RELEVANCE The proposed project is relevant to public health because delirium is a common complication of surgery for older adults that is distressing for patients and their families. The proposal will determine whether caffeine helps reduce risk of delirium and related complications after surgery. The analysis of brain activity during impaired cognition is also relevant to public health because results may provide insight into the mechanism of delirium and Mild Cognitive Impairment, which are syndromes that increase risk of future Alzheimer’s Disease- Related Dementias.

PI_NAMEs: VLISIDES, PHILLIP ELEAS (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acetylcholine;Acute;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Anesthesia procedures;Anesthetics;antagonist;Area;arm;Arousal;Awareness;Blinded;Brain;Caffeine;Caring;Characteristics;Clinical;Clinical Trials;Cognition;Cognitive;cognitive function;cognitive testing;Consumption;Data;Delirium;Dementia;density;design;Diagnostic;Distress;Dose;effective intervention;effective therapy;Electroencephalography;experience;Failure;falls;Family;flexibility;functional decline;Future;Goals;Health Expenditures;Hospitalization;Hour;Impaired cognition;improved;Incidence;insight;Intervention;Intravenous;Length of Stay;Measures;meetings;Memory;mild cognitive impairment;mortality;neural;Neurobiology;Neurocognitive;neurocognitive disorder;novel;older adult;Operative Surgical Procedures;Outcome;Participant;Patients;pharmacologic;Placebo Control;Placebos;postoperative delirium;Postoperative Period;prevent;primary outcome;Process;Public Health;public health relevance;Purinergic P1 Receptors;Randomized;randomized placebo controlled trial;randomized, clinical trials;Recovery;recruit;Reporting;Research;Risk;Risk Reduction;Scalp structure;secondary analysis;secondary outcome;segregation;Severities;Subgroup;Surgical complication;Syndrome;System;Techniques;Testing;Therapeutic;Time;Wakefulness;wireless

PROJECT_TITLE: Caffeine and Postoperative Neurocognitive Recovery

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: JOHNSON CITY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: EAST TENNESSEE STATE UNIVERSITY

PHR: Project Narrative This grant examines the roles of ciliary neurotrophic factor (CNTF) and focal adhesion kinase (FAK) inhibition on olfactory neuroplasticity and function. We will use behavioral, genetic and pharmacological approaches to define the roles of CNTF and FAK inhibition-induced CNTF expression in regulating olfactory neuroplasticity and function following acute and chronic olfactory epithelium injury. We expect to identify a novel target, FAK, for injury-related loss of the sense of smell.

PI_NAMEs: JIA, CUIHONG  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: 2019-nCoV;Acute;Adult;Aging;Anosmia;Autocrine Communication;Axon;axon growth;Basal Cell;behavior test;Behavioral;Blunt Head Injuries;cancer clinical trial;Cell Proliferation;Cell Separation;Cells;Chronic;chronic rhinosinusitis;Ciliary Neurotrophic Factor;Ciliary Neurotrophic Factor Receptor;Clinical;COVID-19;Craniocerebral Trauma;cytokine;Data;Dose;epithelial injury;Failure;Female;Focal Adhesion Kinase 1;Genetic;Genetic Transcription;Goals;Grant;Health;Human;hyposmia;IL6ST gene;improved;In Vitro;in vivo;Infection;Inflammation;inhibitor;Injury;Integrins;Intranasal Administration;JNK-activating protein kinase;kinase inhibitor;Knockout Mice;male;MAPK8 gene;Measures;Mediating;Methimazole;Methods;Modeling;Molecular;mouse model;Mus;nerve stem cell;Nervous System;neurogenesis;Neuronal Plasticity;neutralizing antibody;new therapeutic target;novel;olfactory bulb;Olfactory dysfunction;Olfactory Epithelium;Olfactory Nerve;olfactory neurogenesis;olfactory sensory neurons;Paracrine Communication;Pathway interactions;pharmacologic;Production;Proliferating;Quality of life;receptor;reconstitution;Recovery;Recovery of Function;reinnervation;Reporter;Repression;response;Role;Safety;side effect;Signal Transduction;Smell Perception;stem cells;Testing;Therapeutic;TNF gene;Virus Diseases

PROJECT_TITLE: Improving olfactory neuroplasticity through FAK/CNTF signaling


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences

ORG_DEPT: PSYCHOLOGY

PHR: Project Narrative Compared to healthy controls, patients with various mental disorders (e.g., schizophrenia, ADHD, etc) show slower improvement and worse peak performance during the learning of new tasks. Declines in task learning may reflect disruptions in long-term memory and executive control, but little is known about the neurocognitive mechanisms underlying the roles of the hippocampal memory system in the encoding of new task information. Using a combination of advanced behavioral methods and brain imaging in healthy young adults, the proposed research program will advance understanding of how the hippocampal memory system supports task learning and will provide valuable new insights into how decreased task learning in mental disorders may be linked to previous findings of hippocampal abnormalities in these disorders, which will further inform us how to better detect and restore declines in task learning and improve quality of life in patients.

PI_NAMEs: JIANG, JIEFENG  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Acceleration;Adaptive Behaviors;Affect;Animals;Artificial Intelligence;Attention deficit hyperactivity disorder;Behavior;Behavioral;Brain;Brain imaging;Clinical;Cognitive;cognitive control;Collection;Complex;Data;data visualization;Disease;executive function;experience;experimental study;flexibility;Functional Magnetic Resonance Imaging;Goals;Hippocampus;Human;Human Characteristics;improved;information processing;insight;Intelligence;intelligent agent;Knowledge;Learning;learning ability;Link;long term memory;Maps;Measures;member;Memory;Mental disorders;Methods;Modeling;neural;Neurocognitive;neuroimaging;Participant;Patients;Pattern;Performance;procedural memory;Process;programs;Psyche structure;Quality of life;relational memory;Research;response;Response to stimulus physiology;Retrieval;Role;Schizophrenia;Shapes;Specific qualifier value;Statistical Data Interpretation;Structure;Support System;System;Task Performances;Testing;Thinking;Work;young adult

PROJECT_TITLE: Neurocognitive mechanisms of task representation reorganization during task learning

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Kidney Disease;Pediatric;Urologic Diseases

ORG_NAME: BOSTON MEDICAL CENTER

PHR: Modified Public Health Relevance Section  Proteinuric kidney disease is one of the most common non-communicable diseases that cause substantial morbidity and mortality worldwide. Many patients with proteinuric kidney disease will eventually have kidney failure and need dialysis or kidney transplantation to survive. Successful development of kidney podocyte-specific anti-proteinuric novel therapeutics will delay or halt the progression of proteinuric kidney diseases and kidney failure in patients and change the current standard of medical care.

PI_NAMEs: LU, WEINING  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Actins;Adhesions;Adult;Affect;Albumins;Albuminuria;Animal Model;Biological Response Modifier Therapy;Biopsy Specimen;Birth;Boston;Caring;Chimeric Proteins;Chronic Kidney Failure;Cohort Studies;Collaborations;congenital anomalies of the kidney;cost;Data;density;Dialysis procedure;Disease;Disease Progression;Dominant-Negative Mutation;drug development;early detection biomarkers;efficacy testing;Embryo;Focal Adhesions;Focal and Segmental Glomerulosclerosis;Foot Process;Gel;Genes;glomerular basement membrane;glomerular filtration;Goals;Human;inhibitor;Injury;innovation;Kidney;kidney biopsy;Kidney Diseases;Kidney Failure;Kidney Transplantation;Lead;Length;Ligands;Medical;Metanephric Diverticulum;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mus;Mutation;National Institute of Diabetes and Digestive and Kidney Diseases;nephrin;nephrogenesis;new therapeutic target;non-muscle myosin;Nonmuscle Myosin Type IIA;novel;novel therapeutics;Outcome;Pathway interactions;Patients;Permeability;Persons;Phase II Clinical Trials;phase II trial;Play;podocyte;polymerization;Polymers;Population;Positioning Attribute;pre-clinical;prevent;protein expression;Proteins;Proteinuria;public health relevance;receptor;Reflux;Resistance;Risk Factors;Role;Safety;safety testing;Serum Albumin;Side;Signal Pathway;Signal Transduction;slit diaphragm;Steroids;Structure;Therapeutic;Toxic effect;Transcript;Urinary tract;Urine;Validation;Vascularization;Vesico-Ureteral Reflux

PROJECT_TITLE: New Therapeutic Leads for Proteinuric Kidney Diseases


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE (Overall) The proposed “Center for Team Effectiveness to Accelerate EBP Implementation in Children’s Mental Health Services (TEAMS)” will leverage organizational team effectiveness research (TER) to develop and test novel team-based implementation strategies, methods, and tools to improve the reach, quality, and effectiveness of care delivered in public systems serving children with mental health needs - specialty mental health, schools, pediatric healthcare, and child welfare. The TEAMS Center will create the essential administrative and scientific infrastructure to conduct team-based implementation research to improve children’s mental health outcomes. It will bring together experts in children’s mental health implementation research, EBPs for children and adolescents, implementation strategies, models, and methods, TER, and computer science.

PI_NAMEs: AARONS, GREGORY ;BROOKMAN-FRAZEE, LAUREN  (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;Age;Algorithms;Attention deficit hyperactivity disorder;autism spectrum disorder;Businesses;care systems;career;Caring;Child;Child Care;Child health care;Child Mental Health;child mental health service;child services;Child Welfare;Childhood;Clinical;Communication;Communities;community center;community partners;Community Services;Complex;computer science;cost;data submission;Decision Making;Depression screen;design;design,build,test;Development;Disabling;Early Intervention;Effectiveness;effectiveness research;Ensure;Epidemiology;ethnic disparity;evidence base;Evidence based practice;experience;falls;Family;Fostering;Funding;Health Expenditures;Health Services Accessibility;Healthcare;Healthcare Systems;implementation research;implementation science;implementation strategy;Improve Access;improved;Individual;Infrastructure;interdisciplinary collaboration;Investments;Life;life span;Measures;medical specialties;Mental disorders;Mental Health;Mental Health Services;Methods;Military Personnel;Mission;Modeling;Monitor;Natural Language Processing;novel;operation;Outcome;Parents;Performance;Physicians;Pilot Projects;Prevention;programs;Protocols documentation;Provider;Psyche structure;Quality of Care;Race;Regulation;Research;Research Personnel;Research Project Grants;Research Support;Resources;routine care;Schools;Secondary Prevention;service gap;service organization;Services;shared decision making;skills;Special Education;suicidal risk;System;teacher;Testing;therapy development;tool;Training;Transcript;Work;Youth

PROJECT_TITLE: Center for Team Effectiveness to Accelerate EBP Implementation in Children's Mental Health Services


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Mental Health;Pediatric;Primary Health Care

PI_NAMEs: BROOKMAN-FRAZEE, LAUREN  (contact)

PROJECT_TERMS: Acceleration;Accountability;Area;Awareness;care systems;career;Charge;Child Care;Child health care;Child Mental Health;child mental health service;Child Welfare;cohesion;Communication;Communities;community academic partnership;community collaboration;community engaged research;community partners;community partnership;Community Services;conflict resolution;Data;Decision Making;Development;Effectiveness;effectiveness research;effectiveness/implementation trial;Ensure;Evidence based practice;Exploration, Preparation, Implementation, and Sustainment;Goals;Health Services Research;implementation research;implementation science;Individual;Infrastructure;innovation;Institutional Review Boards;Leadership;medical specialties;member;Mental Health;Mentors;Modeling;Monitor;Operations Research;organizational structure;Pilot Projects;Productivity;Psyche structure;Recording of previous events;Research;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;Resource Sharing;Resources;Safety;Schools;service organization;Services;Site;synergism;System;Team Process;therapy development;Training;Trust

PROJECT_TITLE: Center for Team Effectiveness to Accelerate EBP Implementation in Children's Mental Health Services: Admin Core


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: SAO PAULO

ORG_COUNTRY: BRAZIL

ORG_FIPS: BR

ORG_NAME: UNIVERSITY OF SAO PAULO

PHR: PROJECT NARRATIVE Attention-deficit/hyperactivity disorder (ADHD) is a worldwide prevalent neurodevelopmental condition causing impairments in several life contexts. People with ADHD are at increased risk for poor school performance, educational underachievement, and unemployment, which is related to the elevated economic burden of ADHD. The proposed research is relevant to public health because it will help to disentangle the biological mechanisms involved in the interplay between ADHD and educational attainment, and it was designed to decrease the Eurocentric bias seen in genomic and epigenomic studies in mental health.

PI_NAMEs: ROVARIS, DIEGO LUIZ (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Accidental Injury;Address;Admixture;Adult;Affect;Age;Area;Attention deficit hyperactivity disorder;biobank;Bioinformatics;Biological;Brazil;Characteristics;Childhood;Clinical;Clinical Research;Cognitive;college;Communities;Complex;Country;Cross-Sectional Studies;Data;design;Disease;DNA Methylation;Economic Burden;Education;Enrollment;Environment;Epidemiology;epidemiology study;epigenetic marker;epigenome;epigenomics;ethnic disparity;Ethnic Origin;European;Failure;Future;Gambling;Genetic;genetic association;genome wide association study;genome-wide;Genomics;Goals;Grant;Health;Heritability;High-Income Populations;Hyperactivity;illiteracy;Impairment;Impulsivity;inattention;Income;Individual;instrument;interest;Latin America;Life;Life Expectancy;Link;Literature;Mental disorders;Mental Health;methylation biomarker;Minority;multi-ethnic;Outcome;Performance;Performance at work;Persons;Phenotype;Play;Policy Maker;Population;Population Heterogeneity;Predisposition;Pregnancy in Adolescence;prevent;Psyche structure;Public Health;Public Policy;Quality of life;Reporting;Research;Risk;Role;Sampling;Schools;Science;social;social disparities;Social Environment;Social Impacts;Socialization;Societies;socioeconomics;Substance Use Disorder;success;Suicide;Symptoms;Testing;Translating;Underachievement;Unemployment;Work

PROJECT_TITLE: The biological connection between educational attainment and attention-deficit/hyperactivity disorder in contrasting environments


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Pediatric;Primary Health Care

PI_NAMEs: AARONS, GREGORY  (contact)

PROJECT_TERMS: Acceleration;Address;Area;care systems;Child Care;child health care service;Child Mental Health;child mental health service;child services;Clinical;Code;Collaborations;Communication;Communities;Community Services;Complex;Data;data communication;design;Development;Effectiveness;effectiveness research;Ensure;Evaluation;Evidence based practice;Future;Goals;Health;implementation barriers;implementation research;implementation science;implementation strategy;improved;Incubators;Individual;Industry;innovation;insight;Intervention;Language;Lead;Literature;machine learning classifier;Measurement;Measures;member;Mental Health;Mental Health Services;Methodology;Methods;Military Personnel;Modeling;Natural Language Processing;novel;open source;Organizational Objectives;Performance;Process;Publications;Qualitative Methods;Research;Research Activity;Research Design;Research Personnel;Science;Services;Shapes;Space Explorations;System;Team Process;Technology;Testing;tool;Training;Work

PROJECT_TITLE: Center for Team Effectiveness to Accelerate EBP Implementation in Children's Mental Health Services: Methods Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative The proposed research is relevant to public health because understanding the mechanism of Embryonal Rhabdomyosarcoma progression is expected to deepen our understanding of how developmental transcription factors are reactivated in disease, and to provide evidence that targeting these developmental genes (which are no longer required in most differentiated cells) may be a novel means to inhibit RMS without the associated toxicities of most therapies. Such toxicities can be particularly devastating to children, and thus novel therapies, developed through the generation of unique animal models such as human xenograft into mice and zebrafish models, are clearly needed to identify new means to treat the disease. Thus, the proposed research is relevant to the NCI mission that pertains to advancing scientific knowledge and helping all people to live longer, healthier lives.

PI_NAMEs: ARTINGER, KRISTIN ;FORD, HEIDE L. (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Adult;Animal Model;Animals;ATAC-seq;Automobile Driving;Binding;Biological Assay;Biological Models;cancer cell;Cancer Patient;Cell Differentiation process;Cells;Chemoresistance;Child;Childhood;childhood cancer survivor;Chromatin;chromosome fusion;Cleavage Under Targets and Release Using Nuclease;cofactor;Coupling;Data;design;Development;Developmental Gene;Diagnosis;Disabling;Disease;DNA Binding;Drug Targeting;Embryo;Embryonal Rhabdomyosarcoma;Embryonic Development;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;epigenomics;experience;experimental study;gain of function;Generations;Genes;Genetic;Genome engineering;genome-wide;Genomics;Growth;Human;human model;Individual;insight;Invaded;knock-down;Knock-out;knockout gene;Knowledge;Lead;Life;Maintenance;Malignant Childhood Neoplasm;Malignant Neoplasms;malignant phenotype;Mass Spectrum Analysis;Mesoderm Cell;migration;Mission;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Muscle;Muscle Development;muscle progenitor cell;Myoblasts;Myogenic Regulatory Factors;Neoplasm Metastasis;new therapeutic target;Normal Cell;novel;novel therapeutic intervention;novel therapeutics;overexpression;Patients;Pediatric Neoplasm;Pediatric Oncology;Persons;pharmacologic;Phenotype;Physicians;Play;pre-clinical;precursor cell;progenitor;programs;Proliferating;Proteins;Public Health;Research;Rhabdomyosarcoma;Role;Sarcoma;Scientific Advances and Accomplishments;Scientist;side effect;small molecule inhibitor;Soft Tissue Neoplasms;stem;stem cell expansion;Survival Rate;System;targeted treatment;Techniques;Testing;therapeutic development;Tissue Differentiation;Tissues;tool;Toxic effect;transcription factor;transcriptomics;treatment strategy;Treatment-related toxicity;tumor;tumor growth;tumor progression;Tumor stage;Undifferentiated;Work;Xenograft procedure;Zebrafish

PROJECT_TITLE: Reprogramming myogenic regulatory factors in RMS to promote differentiation and halt growth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-W(02)M]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Mental Health;Pediatric

PROJECT_TERMS: Acceleration;Adherence;Adult;Affective;Agreement;Attention deficit hyperactivity disorder;Attenuated;Awareness;Behavior;Behavior Therapy;Behavioral;Child;child mental health service;child services;Child Support;Clinical Trials;Cluster randomized trial;Cognitive;cohesion;Communication;Conflict (Psychology);Data;data communication;Data Sources;Development;Effectiveness;effectiveness evaluation;effectiveness research;effectiveness trial;Ensure;Event;evidence base;Evidence based intervention;expectation;Feedback;Focus Groups;Goals;Health Personnel;Home;Hybrids;Impairment;implementation outcomes;implementation protocol;implementation strategy;improved;Impulsivity;Intervention;Life;Measurement;Mediating;Medical;meetings;member;Mental Health;Methods;Modeling;Monitor;Motivation;Natural Language Processing;Neurodevelopmental Disorder;operation;Outcome;parenting intervention;Parents;Patient Care;peer;Perception;Performance;Policies;Procedures;Process;programs;Protocols documentation;Psyche structure;Randomized;Reporting;Research;Resources;Role;school district;School Health Services;School Teachers;Schools;skills;skills training;social;Specific qualifier value;Students;success;Symptoms;teacher;Team Process;Testing;therapy development;tool;Training;Trust;urban school;web site;Work;Writing

PROJECT_TITLE: Enhancing team effectiveness for a collaborative school-based intervention for ADHD


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: CHAMPAIGN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: This is a competing continuation application to renew the Research Training Program in Toxicology and Environmental Health at the University of Illinois at Urbana-Champaign. The Program, established in 2000, educates pre-and postdoctoral trainees in reproductive/endocrine toxicology, neurotoxicology, nutritional toxicology, and nanotoxicology.

PI_NAMEs: FLAWS, JODI A. (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Environmental Health;Research Training;Toxicology;Training Programs

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(T)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: PEDIATRICS

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: Project Narrative This study will evaluate the long-term effectiveness of an economic intervention designed to facilitate maternal adherence to pumping and providing mother’s own milk to very preterm infants by covering the costs that serve as barriers to sustained mother’s own milk feedings during the neonatal intensive care unit hospitalization. Additionally, the study will assess the relationship between the total duration mother’s own milk is received during the first year of life and early childhood outcomes in this population of vulnerable infants.

PI_NAMEs: JOHNSON, TRICIA J.;PATEL, ALOKA LAHOTI (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Adherence;Age;Age Months;Brain;breast pump;cardiometabolism;care costs;Caring;Cognitive;cohort;Collection;comparison control;Control Groups;cost;cost comparison;cost effective;cost effectiveness;Data;Data Collection;design;Development;disparity reduction;Dose;early childhood;economic outcome;Economics;Effectiveness;effectiveness testing;Ethics;Event;extreme prematurity;Face;family burden;feeding;Funding;group intervention;Health;Health Care Costs;high risk infant;Home;Hospitalization;Hospitals;Impairment;improved;improved outcome;indexing;Inequity;Infant;Intake;Intelligence quotient;Intervention;Intervention Trial;Investments;Lactation;Language;Life;life span;Measures;Milk;milk intake;Mothers;Motor;Neonatal Intensive Care Units;neurodevelopment;Nutritional;Obesity;obesity risk;Observational Study;opportunity cost;Outcome;payment;Pregnancy;Premature Infant;primary outcome;Pump;Randomized;Randomized, Controlled Trials;Recommendation;Residual state;Risk;Risk Reduction;therapy design;Translating;treatment group;United States National Institutes of Health;Very Low Birth Weight Infant;Vulnerable Populations

PROJECT_TITLE: Early Childhood Neurodevelopmental, Economic and Nutritional Outcomes among Former Very Low Birth Weight Infants from the Reducing Disparity in Mother's Own Milk (ReDiMOM) Trial

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The COVID-19 pandemic significantly impacted the United States’ health care system and disproportionately affected vulnerable populations (i.e., elderly people of color and rural). Home healthcare agencies (HHAs) and nursing homes (NHs) provide essential care for a large number of elderly patients post hospital discharge. This study will examine the impact of COVID-19 pandemic on care transitions between hospitals, HHAs and NHs as well as patient outcomes. The study also examines the effectiveness of infection prevention and control practices in HHA and NHs in reducing the impact of COVID-19.

PI_NAMEs: SHANG, JINGJING  (contact);STONE, PATRICIA W.

PROGRAM_OFFICER_NAME: DUAN, LEWEI

PROJECT_TERMS: access disparities;Acute;acute care;Acute myocardial infarction;Administrator;Admission activity;Affect;beneficiary;burden of illness;Caring;Cessation of life;Communicable Diseases;comorbidity;Core Facility;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 risk;Crowding;Data;Data Sources;design;Diagnosis;Effectiveness;effectiveness evaluation;Elderly;Emergency Situation;Environment;ethnic minority;experience;Future;Health;Health Care Surveys;health disparity;Health Services Accessibility;Healthcare;Healthcare Systems;High Prevalence;high risk;high risk population;Home Health Care Agencies;Home Nursing Care;hospital readmission;Hospitalization;Hospitals;improve minority health;improved;Individual;Infection;Infection Control;Infection prevention;Infrastructure;innovation;Inpatients;Interview;Knowledge;Link;Medicare;Medicare/Medicaid;Methods;Mission;Modeling;mortality;National Institute on Minority Health and Health Disparities;nosocomial infection control;Nosocomial Infections;novel;Nursing Homes;older patient;Outcome;pandemic disease;pandemic impact;Patient-Focused Outcomes;Patients;people of color;Policies;Policy Maker;Population;post-COVID-19;programs;Public Health;Quality of Care;racial minority;Recommendation;Reduce health disparities;Replacement Arthroplasty;Research;response;Risk Reduction;Rural;Rural Community;rural dwellers;rural setting;Sampling;Sepsis;Services;social health determinants;Stroke;Surveys;Time;United States;United States Centers for Medicare and Medicaid Services;Visiting Nurse;Vulnerable Populations;Work

PROJECT_TITLE: ImpAct of COVID-19 on CaRe TransitOns and Health OutcomeS for Vulnerable PopulationS in Nursing Homes and Home HealthCARE Agencies (ACROSS-CARE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(58)R]


ORG_CITY: MADISON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE – OVERALL Genome editors make targeted changes in the genome and hold great promise in translational research but moving them into investigational new drugs has been slow and challenging. The majority of products in development target the liver or utilize viral vectors. Because these strategies are limiting for many diseases, especially those that affect post-mitotic cells in complex tissues like the eye, the CRISPR Vision Program seeks to develop novel human genome editing therapeutic platforms for transient, localized, and nonviral treatment of multiple inherited retinal disorders, specifically channelopathies affecting the retinal pigment epithelium.

PI_NAMEs: SAHA, KRISHANU  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Academia;Address;Adverse event;Affect;Animal Model;Animals;Anniversary;base editor;Blindness;Cell Culture Techniques;Cells;Cellular Assay;Clinic;clinic ready;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;CRISPR/Cas technology;Data;Dependovirus;Development;Disease;Dose;Elements;European;experience;Eye;Eye diseases;Face;Genes;Genome;genome editing;genome editor;Genotype;Good Manufacturing Process;Guide RNA;Human;Human Genome;Immune response;Immunosuppression;in vivo;induced pluripotent stem cell;Industry;Inherited;innovation;interest;Investigational Drugs;Investments;Ion Channel;Knowledge;Lead;Learning;Leber's amaurosis;Liver;manufacture;Medicine;Modeling;mouse model;mRNA delivery;Mutation;nanocapsule;next generation;Nobel Prize;Nonhomologous DNA End Joining;nonhuman primate;novel;nuclease;Organoids;Palpable;Paper;Pathologic;patient derived induced pluripotent stem cells;Patients;Pharmaceutical Preparations;Photoreceptors;postmitotic;pre-clinical;Preclinical Testing;programs;Proteins;Publishing;Rare Diseases;Recombinant adeno-associated virus (rAAV);repaired;Research;response;Retina;Retinal Diseases;Ribonucleoproteins;Safety;Silicon Dioxide;Somatic Cell;Specificity;Structure of retinal pigment epithelium;supply chain;synergism;System;Technology;Testing;Therapeutic;Therapeutic Effect;therapeutic genome editing;Time;Tissues;TP53 gene;Translating;Translational Research;Translations;vector;Viral;Viral Vector;Vision;Vitelliform macular dystrophy

PROJECT_TITLE: The CRISPR Vision Program: Nonviral Genome Editing Platforms to Treat Inherited Retinal Channelopathies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-G(70)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurosciences

PROJECT_TERMS: Administrator;Adopted;Animal Model;Area;Biology;Brain;Cell model;Cells;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communication;Computer software;cost effective;Data;Data Reporting;Data Set;data sharing;Engineering;Ensure;experience;Extramural Activities;Foundations;gene editing technology;genome editing;Goals;Grant;Human Resources;industry partner;Infrastructure;Inherited;innovation;Institution;Lead;Leadership;Logistics;manufacturing facility;manufacturing technology;meetings;member;nanoparticle delivery;Occupational activity of managing finances;Patients;Personnel Management;Phase;Policies;pre-clinical;Process;programs;Protocols documentation;Publications;Reporting;Research;Research Personnel;Resources;Retina;Retinal Diseases;Science;Software Tools;somatic cell gene editing;Staff Work Load;synergism;Technology;therapeutic candidate;therapeutic genome editing;timeline;Translations;United States Food and Drug Administration;United States National Institutes of Health;Universities;Validation;Vision;Wisconsin;Work

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-G]


ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The mechanisms bacteria use to sense and respond to environmental signals are crucial for maintaining symbiotic associations with host cells. The proposed project will increase understanding of the proteins and small molecules that bacteria use to adapt to oxidizing conditions in the host, with the long-term goal of identifying pathways that can be targeted to support the diagnosis, treatment, and prevention of bacterial diseases.

PI_NAMEs: HATZIOS, STAVROULA  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Anabolism;Animal Model;animal tissue;Anti-Infective Agents;Antioxidants;Bacteria;Bacterial Infections;Bacterial Model;Bacterial Proteins;Biology;Cells;Chemicals;Chronic;Coculture Techniques;commensal microbes;Diagnosis;Drug Metabolic Detoxication;Environment;environmental adaptation;Enzymes;Epithelial Cells;Epithelium;Equilibrium;Eukaryotic Cell;Event;Exposure to;gastrointestinal;Gene Expression;Genetic;Goals;gut colonization;gut microbiota;Helicobacter pylori;Homeostasis;host colonization;host-microbe interactions;Immune response;in vivo;Life;Mediating;member;Metabolism;Methods;Microbe;microbial;microbial colonization;Modification;Molecular;Molecular Weight;novel;oxidation;Oxidation-Reduction;Oxidative Stress;Pathway interactions;Physiological;Prevention;Process;Property;Proteins;Proteomics;rational design;Reactive Oxygen Species;Regulation;response;Role;Shapes;Signal Pathway;Signal Transduction;small molecule;Stomach;Stress;Sulfhydryl Compounds;symbiont;tool;uptake;Work

PROJECT_TITLE: Understanding redox-regulated mechanisms of environmental adaptation in gastrointestinal symbionts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurosciences;Orphan Drug;Rare Diseases

PI_NAMEs: GAMM, DAVID M (contact)

PROJECT_TERMS: Acceleration;Adverse event;Affect;Aftercare;Alleles;Animal Model;autosome;Biological Assay;Biological Markers;Biological Models;biological systems;biomarker identification;biomarker panel;Biomedical Engineering;Blood;Calcium;Cell Physiology;cell type;Cells;Cellular Assay;cellular targeting;Chloride Channels;CLCA2 gene;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;cost;Data;Disease;DNA Sequence;Dose;Electrophysiology (science);Epigenetic Process;Epithelial Cells;Exposure to;Eye;first-in-human;Frequencies;gene regulatory network;gene therapy;Gene therapy trial;Genes;Genetic Transcription;genome editing;genome editor;genome integrity;Genomics;Genotype;Goals;Guide RNA;Human;human induced pluripotent stem cells;human pluripotent stem cell;Image;in vivo;induced pluripotent stem cell;Inherited;Innate Immune Response;insight;Investigational Drugs;Ion Channel;Knock-in;Lead;Leber's amaurosis;Libraries;Measurement;metabolic imaging;Modification;mutant;Mutation;next generation sequencing;off-target site;Optics;Organoids;Outcome;Pathogenicity;Patients;Phase;Phenotype;Photoreceptors;Phototransduction;pre-clinical;Preparation;programs;Publishing;Reproducibility;response;Retina;retinal progenitor cell;Route;Safety;skin biopsy;Source;stem cell biology;stem cell model;Structure of retinal pigment epithelium;Testing;Therapeutic;therapeutic candidate;Time;Tissues;tool;TP53 gene;transcriptomics;Translations;Universities;Vision;Vitelliform macular dystrophy;Wisconsin;Work

PROJECT_TITLE: Human Cell Assay Core


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Narrative Lung inflammation in response to pulmonary infectious agents is characterized by an acute potentially damaging phase and a resolution phase. Extension of the acute phase may lead to pulmonary tissue injury and acute respiratory distress syndrome, a highly lethal condition. This proposal seeks to test the idea that reactive oxygen species (ROS) produced in the nucleus of macrophages prevent the transition of inflammation from the acute to the resolution phase increasing the risk of ARDS in patients prone to develop oxidative stress (i.e. elderly, smokers, patients with underlying metabolic conditions). It also advances the idea that targeted antioxidants may be used as therapeutics in these patients to prevent ARDS.

PI_NAMEs: BONINI, MARCELO G. (contact);GANTNER, BENJAMIN N.

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Affect;Alveolar;Anti-Inflammatory Agents;Antioxidants;Autoimmunity;Bacteria;Bacterial Pneumonia;bactericide;Binding Proteins;catalase;Cell Nucleus;Cells;ChIP-seq;CISH gene;Clinical;Confocal Microscopy;Critical Illness;Cysteine;Data;Deposition;Development;Diffuse;Elderly;Environment;Epigenetic Process;Equilibrium;experience;fighting;gene network;Gene Targeting;Genes;Genetic Engineering;Genetic Transcription;genomic locus;Goals;healing;Homeostasis;human old age (65+);Hydrogen Peroxide;Immune;Immune response;Immunosuppressive Agents;Infection;Infectious Agent;Inflammation;Inflammatory;inhibitor;Injury;Klebsiella pneumoniae;Knock-in Mouse;knockout animal;Licensing;Lung;Lung infections;lung injury;Macrophage;Mediating;Metabolic;Metabolic syndrome;Modeling;Modification;Molecular;monocyte;mortality;mouse model;Mus;neutrophil;Neutrophil Activation;Nitric Oxide;Nitric Oxide Synthase Type I;Nitrogen;novel;Nuclear;Nucleic Acid Regulatory Sequences;Output;Overweight;Oxidants;oxidation;Oxidation-Reduction;Oxidative Stress;Oxygen;p65;pathogenic microbe;Pathway interactions;Patients;Phase;Phenotype;Pneumonia;Population;Predisposition;preservation;Prevalence;prevent;Prevention;Production;promoter;Promoter Regions;Publishing;Pulmonary Inflammation;Pulmonology;Reactive Oxygen Species;recruit;Regulatory Element;Research;Resolution;response;Risk;Role;Signal Transduction;Smoker;Smoking;Specific qualifier value;Speed;Sterility;Structure of parenchyma of lung;surfactant production;SWI1;Testing;Therapeutic;tissue injury;tissue repair;Tissues;TNFRSF5 gene;transcription factor;ubiquitin-protein ligase

PROJECT_TITLE: A redox-sensitive switch in the macrophage nucleus regulates acute phase inflammatory injury

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

PHR: PROJECT NARRATIVE In principle, stem cells can be directed to produce desired cell types for transplantation, disease modeling, and drug testing, which is the basis for their tremendous scientific and therapeutic potential. However, we have not yet realized this potential because we do not fully understand the regulatory mechanisms that maintain stem cells and instruct their differentiation. The research outlined in this proposal will define the regulatory role of methylation at two key histone residues, H3K9 and H3K36, in directing differentiation, both in vitro and in vivo.

PI_NAMEs: BRUMBAUGH, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Adult;Basic Science;Cell Culture System;cell type;Cells;Chromatin;Development;directed differentiation;disease model;Dominant-Negative Mutation;Doxycycline;drug testing;Embryo;Enzymes;Epigenetic Process;Gene Expression;Genes;Goals;Grant;Histone H3;histone modification;Histones;In Vitro;in vivo;Individual;inhibitor;innovation;insight;Lysine;mammalian genome;Medicine;Methionine;Methylation;Molecular;Mutagenesis;mutant;Mutation;Physiological;Pluripotent Stem Cells;Research;Role;Site;stem cell function;stem cells;System;Testing;Therapeutic;Time;tissue culture;Tissues;tool;Transplantation;Withdrawal;Work

PROJECT_TITLE: DEFINING REGULATORY ROLES FOR HISTONE H3 METHYLATION IN DEVELOPMENT

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurosciences

PI_NAMEs: NORK, T MICHAEL (contact)

PROJECT_TERMS: Acceleration;Adverse effects;Affect;Age related macular degeneration;Animals;Autopsy;Behavior monitoring;Bulla;Clinical;clinical examination;Clustered Regularly Interspaced Short Palindromic Repeats;Color;Communication;Cone;Data;Distal;dosage;Dose;drug distribution;drug testing;Drug toxicity;Electrophysiology (science);Electroretinography;Ensure;Equipment;Evaluation;Evolution;experience;Eye;Feedback;Fluorescein Angiography;Formulation;fovea centralis;Fundus;fundus imaging;genome editing;genome editor;Goals;good laboratory practice;Health;health assessment;Human;in vivo;in vivo evaluation;Individual;Industry;industry partner;Inherited;Injections;Injury;innovation;insight;Investigational Drugs;Laboratories;Lead;Leber's amaurosis;Life;macula;Mammals;Methods;minimally invasive;Monitor;Morphology;nonhuman primate;Operative Surgical Procedures;Optical Coherence Tomography;Pathologic;Patients;pre-clinical;Predisposition;Primates;Principal Investigator;Procedures;programs;Protocols documentation;Recording of previous events;Research;Research Personnel;Retina;Retinal Cone;retinal toxicity;Retrieval;Route;safety assessment;Scanning;Services;Standardization;Sterility;subretinal injection;Surgeon;synergism;systemic toxicity;Techniques;Testing;Therapeutic;therapeutic candidate;Time;tissue preparation;Toxic effect;Toxicity Tests;Toxicology;Universities;Veterinary Medicine;Veterinary Schools;Vision;Visual evoked cortical potential;Vitrectomy;Wisconsin

PROJECT_TITLE: Large Animal Core


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Cell growth triggers human cell division at the G1/S transition before DNA is replicated, but our molecular understanding of this process is poor. Here, we propose to definitively test molecular models for how cell growth triggers division both in cell culture and in vivo in mouse epidermal stem cells. Determining how cell growth triggers cell division will impact our understanding of developmental biology and cancer, where it is misregulated.

PI_NAMEs: SKOTHEIM, JAN M (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;Address;Anabolism;Animals;B-Lymphocytes;Biological Assay;Blood capillaries;Cell Aging;Cell Culture Techniques;Cell Cycle;Cell Cycle Proteins;Cell division;cell growth;Cell Physiology;Cell Proliferation;Cell Size;cell type;Cells;Cellular biology;Chemicals;Code;Coupling;Cultured Cells;Cyclin D1;Data;Dependence;Developmental Biology;DNA;DNA Sequence;Elements;epidermal stem cell;Epidermis;Erythrocytes;expectation;experimental study;G1/S Transition;G2 Phase;Gene Family;Genetic;genetic regulatory protein;Grant;Growth;Human;in vivo;in vivo imaging;inhibitor;keratinocyte;Knowledge;Laboratories;Link;link protein;live cell imaging;live cell microscopy;Macrophage;Malignant Neoplasms;Mammalian Cell;Mammals;Mass Spectrum Analysis;Measures;Messenger RNA;Modeling;Molecular;molecular modeling;molecular size;mouse genetics;Mus;Nuclear Proteins;Outcome;overexpression;p38 Mitogen Activated Protein Kinase;pathogen;Pathology;Phase;Phenotype;Physiological;Pilot Projects;Population;Process;Proteins;Proteome;Reporter;Reporting;Retinoblastoma Protein;S phase;senescence;Series;Sorting;stem cell proliferation;stem cells;stress activated protein kinase;Testing;Translations;two photon microscopy;two-photon;Work

PROJECT_TITLE: Determining how cell growth triggers cell division in epidermal stem cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-C(02)M]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurosciences;Orphan Drug;Rare Diseases;Regenerative Medicine

PI_NAMEs: RASMUSSEN, CATHY  (contact)

PROJECT_TERMS: Address;Animal Model;Animals;authority;Biological Products;Cell Therapy;Cellular Assay;Clinical assessments;clinical translation;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communication;Consensus;Data;Development;Documentation;Elements;Eligibility Determination;Ensure;experience;Feedback;first-in-human;Foundations;gene therapy;Generations;genome editing;genome editor;Goals;Human;human pluripotent stem cell;Immune response;improved;Individual;Inherited;Knowledge;Measures;Medical;meetings;Monitor;Outcome;Pharmacologic Substance;pre-clinical;pre-Investigational New Drug meeting;preclinical development;Preclinical Testing;product development;programs;Rare Diseases;Recommendation;Regenerative Medicine;Regulatory Affairs;Reporting;research clinical testing;Research Project Grants;Resources;Retina;Risk;risk mitigation;Safety;small molecule;Somatic Cell;Standardization;stem cell model;Strategic Planning;success;synergism;System;Technology;Testing;Therapeutic;therapeutic development;therapy development;timeline;Toxicology;Translational Research;Vision;Work

PROJECT_TITLE: Regulatory Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The goal of the Summer Research Program for Diversity Students in PharmacoNeuroImmunology is to increase the participation of underrepresented individuals in interdisciplinary biomedical research. This goal will be accomplished by structured research experiences in the area of drug abuse by providing skill sets for careers in biomedical sciences.

PI_NAMEs: CARROLL, DANA MOWLS;CHEERAN, MAXIM CHACKO-JOSEPH;MOLITOR, THOMAS WILLIAM (contact)

PROGRAM_OFFICER_NAME: FRIEND, LINDSEY NICOLE

PROJECT_TERMS: Advisory Committees;Area;Behavior;Behavioral;Biological Sciences;Biomedical Research;biomedical scientist;career;Career Choice;Communities;Data;Development;disability;Disadvantaged;Doctor of Philosophy;Drug abuse;drug of abuse;Economics;Educational Curriculum;Enrollment;Ensure;Ethics;Ethnic Origin;Evaluation;experience;Faculty;faculty mentor;Funding;Future;Gender;Goals;Immune system;Individual;innovation;Institution;interest;Joints;Journals;Laboratories;Learning Module;Measures;medical schools;meetings;member;Mentors;Mentorship;Minnesota;Mission;National Institute of Drug Abuse;Nervous System;Outcome Assessment;Participant;Phase;Physiological;Positioning Attribute;Postdoctoral Fellow;posters;pre-doctoral;programs;Puerto Rico;Qualifying;Quality of life;Race;recruit;Research;role model;Safety;Science;Series;skills;Social Interaction;stem;Structure;Students;summer program;summer research;summer student;Surveys;symposium;Training;Training and Infrastructure;training opportunity;Training Programs;undergraduate research experience;undergraduate student;Underrepresented Students;United States Department of Agriculture;United States National Institutes of Health;United States Virgin Islands;Universities;Work


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: TEMPE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project narrative relevance  Alternative polyadenylation (APA) is an elusive process observed in virtually all metazoans that produces genes with different mRNA 3’end isoforms and allows genes to escape the negative regulation exerted by miRNAs and RNA binding proteins.  Is unclear how these regulatory networks functions in cells, how APA is achieved, and which elements miRNA specifically target, but disruption in these basic processes has been implicated in a broad array of human diseases such as cancer, Alzheimer’s, and muscular dystrophies.  The experiments described in this research grant use a unique combination of genetics, biochemistry, bioinformatics and HT genomics taking advantage of the extensive genetic knowledge of the round nematode C. elegans to shed light on these important processes, produce unparalleled amount of information regarding APA reaction, and provide an unprecedented resource for the worm community. 1

PI_NAMEs: MANGONE, MARCO  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: 3' Untranslated Regions;Alzheimer's Disease;base;Biochemistry;Bioinformatics;Biological;Biological Models;Biology;Caenorhabditis elegans;Cell Lineage;Cells;cis acting element;Cloning;Communication;Communities;Complex;Coupled;Cytoplasm;Data;Data Set;Databases;Development;Disease;dosage;Elements;Event;Experimental Genetics;experimental study;Gene Expression;Gene Expression Regulation;Gene Rearrangement;Genes;Genetic;genetic manipulation;genetic signature;Genetic Transcription;Genome;Genomics;Goals;Grant;Homologous Gene;Human;human disease;Immunoprecipitation;improved;in vivo;insight;Intestines;Knowledge;Length;Malignant Neoplasms;Manuals;Maps;Mechanics;member;Messenger RNA;Methods;MicroRNAs;Modification;Molecular;mRNA Translation;Muscle;Muscular Dystrophies;N-Methylaspartate;Nematoda;Neurons;novel;Nuclear;Organism;Pattern;Pharyngeal structure;Physiological;Polyadenylation;Population;Post-Transcriptional Regulation;posttranscriptional;Process;Production;Protein Isoforms;Proteome;Reaction;Regulation;Regulatory Element;Repression;Research;Research Project Grants;Resolution;Resources;RNA Binding;RNA-Binding Proteins;Role;Signal Transduction;Site;Sorting;Subcutaneous Tissue;Tail;Terminator Codon;Testing;Tissues;tool;transcription regulatory network;transcriptome;Update;Validation;virtual

PROJECT_TITLE: Genetics and Genomics of Alternative Polyadenylation and miRNA Regulation in C. e - Renewal - 1


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Nanotechnology;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: GONG, SHAOQIN - (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Alleles;Animals;base editing;base editor;Biological Products;biological systems;Biomanufacturing;biomaterial compatibility;Blindness;cell type;Cells;Cellular Assay;cGMP production;Chemicals;Chemistry;Childhood;Clinical;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Data;Development;Dose;Drug Packaging;Engineering;Eye;FDA approved;Formulation;functional restoration;Future;gene correction;gene therapy;Genes;genome editing;genotoxicity;Good Manufacturing Process;Guide RNA;Human;human induced pluripotent stem cells;Immune;In Vitro;in vivo;induced pluripotent stem cell;Inherited;Investigational Drugs;Investigational New Drug Application;inward rectifier potassium channel;Kir7.1 channel;Knowledge;Lead;lead candidate;Leber's amaurosis;Ligands;manufacture;manufacturing facility;manufacturing scale-up;Mediating;meetings;Messenger RNA;Methods;Modality;mouse model;Mus;mutation correction;nanocapsule;nonhuman primate;novel therapeutics;Particle Size;patient derived induced pluripotent stem cells;Pharmaceutical Preparations;Point Mutation;pre-clinical;pre-Investigational New Drug meeting;preclinical study;Prevalence;Process;process optimization;Production;programs;Property;Quality Control;rare condition;Rattus;Research Contracts;Research Methodology;Retina;Retinal Diseases;Running;Safety;safety study;scale up;Silicon Dioxide;small molecule;Specificity;Structure of retinal pigment epithelium;subretinal injection;success;Surface;Technology Transfer;Testing;Therapeutic Effect;therapeutic genome editing;Toxic effect;Toxicology;Translations;Tretinoin;Validation;Vision

PROJECT_TITLE: Silica Nanocapsule-Mediated Nonviral Delivery of CRISPR Base Editor mRNA and Allele Specific sgRNA for Gene Correction in Leber Congenital Amaurosis