NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Microbiome;Sexually Transmitted Infections;Social Determinants of Health;Topical Microbicides;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE: Transgender men (TGM) taking testosterone as gender-affirming hormone therapy often experience changes affecting their vaginal health such as thinning of the vaginal epithelium, inflammation, and unfavorable shifts in the vaginal microbiota which can lead to bacterial vaginosis. Such changes, in conjunction with sexual behaviors of TGM, are associated with negative sexual health outcomes such as increased risk of HIV and sexually transmitted infection (STI) acquisition and symptoms such as irritation, discharge, and dyspareunia. The proposed research in this K23 proposal aims to utilize community-engaged mixed methods research to develop culturally relevant clinical tools that can be used by healthcare providers to collect both vaginal history data (via a vaginal health survey instrument) and clinical specimen data (via self-collected vaginal swabs) to better assess and manage vaginal symptoms that TGM experience and, ultimately, improve their sexual health outcomes.

PI_NAMEs: VAN GERWEN, OLIVIA TELLE (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: acceptability and feasibility;Active Learning;Adult;Advisory Committees;Affect;Alabama;Atopobium vaginae;Atrophic;bacterial community;Bacterial Vaginosis;career development;Caring;Clinical;clinical development;clinically relevant;Cognitive;Collaborations;Collection;Communicable Diseases;Communities;community engagement;Cross-Sectional Studies;Data;Development Plans;Discrimination;dysbiosis;Dyspareunia;dysphoria;Enrollment;Epithelium;experience;Frequencies;Fright;Future;Gender;gender affirming hormone therapy;gender diverse;gender dysphoria;gender minority health disparity;gender transition;Goals;Guidelines;Health;Health Disparities Research;health disparity;Health Personnel;Health Services;Health Surveys;Healthcare;HIV;improved;Individual;Infection;Inflammation;informant;instrument;Intervention;Interview;irritation;Knowledge;Lactobacillus;Language;Longitudinal Studies;Measures;Medical;Medicine;Mentorship;Methods;metoidioplasty;National Institute on Minority Health and Health Disparities;Needs Assessment;nonbinary;Nucleic Acid Amplification Tests;Odors;Operative Surgical Procedures;Outcome;Outcomes Research;Pain;Participant;Patients;Persons;phalloplasty;Population;population health;Population Heterogeneity;Positioning Attribute;Prevalence;Property;Provider;Psychometrics;Recording of previous events;recruit;Reporting;Reproductive History;Research;Research Methodology;Research Personnel;Risk;Risk Factors;Risk Reduction;sample collection;Sampling;Sex Behavior;Sexual and Gender Minorities;Sexual Health;Sexually Transmitted Diseases;skills;sociodemographics;Specimen;Speculums;Standardization;Surveys;Swab;Symptoms;Testosterone;Thinness;tool;Training;transgender;transgender men;transmasculine;usability;Vagina;vaginal infection;vaginal microbiota;Vaginitis;Visit;Work

PROJECT_TITLE: Assessing and Promoting Vaginal Health for Transgender Men on Testosterone: A Mixed Methods Study

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Congenital Structural Anomalies;Genetics;Neurosciences;Nutrition;Obesity;Pediatric;Rare Diseases

ORG_CITY: TUCSON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Prader-Willi Syndrome and Shafer-Young Syndrome are serious developmental genetic disorders that are associated with insatiable appetite and the development of morbid obesity later in childhood. The proposed research will determine the neural mechanism underlying the impaired satiation. The results will suggest novel strategies to control appetite in these diseases and improve quality of life.

PI_NAMEs: CAI, HAIJIANG  (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Accounting;Adult;Affect;Amygdaloid structure;Animal Model;Animals;Brain;Cell Nucleus;Childhood;Cholecystokinin;Chromosomes;comparison control;Comprehension;Consumption;Desire for food;Development;developmental genetics;Disease;Dose;Eating;Eating Behavior;effective therapy;Electrophysiology (science);excessive weight gain;feeding;Food;food consumption;FOS gene;Gastrointestinal tract structure;Gene Mutation;Genes;Genetic;Genetic Diseases;Genetic Markers;Human;Hyperphagia;Image;Impairment;improved;in vivo;in vivo calcium imaging;Individual;Injections;insight;Interoception;Intraperitoneal Injections;Investigation;Knockout Mice;Knowledge;Label;loss of function;Mediating;Membrane Potentials;Metabolism;microendoscope;Modification;Morbid Obesity;Mus;Mutation;Nausea;neural circuit;neuromechanism;neuronal circuitry;neuronal excitability;Neurons;new therapeutic target;novel;novel strategies;Obesity;optogenetics;Outcome;Patients;Peripheral;Phenotype;Plasma;Play;Population;Prader-Willi Syndrome;prevent;Property;protein expression;protein kinase C-delta;Quality of life;Rattus;Research;Resistance;response;Rest;Role;Satiation;Signal Transduction;Slice;stem;Syndrome;Testing;Translating;Weaning;Work

PROJECT_TITLE: Neural Mechanism of Impaired Satiation After Magel2 Mutation

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Genetics;Human Genome

ORG_CITY: BOSTON

ORG_NAME: JOSLIN DIABETES CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Failure of pancreatic β-cells to secrete sufficient insulin hormone to regulate blood glucose is a hallmark of diabetes. Early during the development of diabetes, prolonged high glucose levels reduce insulin protein synthesis and may also adversely impact the quality of protein produced. By revealing novel mechanisms through which high glucose regulates insulin protein production and affects quality control during protein synthesis, this study has the potential to identify new targets for treating or slowing down the progression of diabetes.

PI_NAMEs: CHERUIYOT, ABIGAEL  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Acute;Affect;Alternative Splicing;autoimmune pathogenesis;Autoimmunity;Beta Cell;Blood Glucose;Cell Line;Cell Physiology;cell replacement therapy;Cell Survival;Cells;Chronic;Collection;Coupled;cytokine;Darkness;Data;Development;Diabetes Mellitus;diabetes pathogenesis;Dissociation;Down-Regulation;endoplasmic reticulum stress;Environment;Evaluation;Exocytosis;Failure;Functional disorder;Genes;genome-wide;genome-wide analysis;Glucose;Government;Hormones;Human;Hyperglycemia;IGF2 gene;Impairment;improved;In Vitro;in vivo;Incubated;Initiator Codon;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;insulinoma;islet;Left;Mass Spectrum Analysis;Mediating;Messenger RNA;Metabolism;Modeling;mRNA Surveillance;mRNA Translation;mutant;neoantigens;new therapeutic target;Nonsense Codon;novel;Nutrient;Open Reading Frames;Oxidative Stress;Pancreatectomy;Pathway interactions;Patients;Persons;Phosphorylation;Prevention;Process;Production;Protein Biosynthesis;Proteins;Proteomics;Quality Control;Rattus;Reporter;Research;response;Ribosomal Proteins;ribosome profiling;Ribosomes;RNA;RNA Decay;Rodent;Role;Sampling;Secretory Vesicles;Structure of beta Cell of islet;T-Lymphocyte;Testing;Toxic effect;Translating;Translation Initiation;Translational Regulation;Translations;Up-Regulation

PROJECT_TITLE: Pancreatic beta-cell glucose toxicity and mRNA translation

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurosciences;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Problematic alcohol use unfolds dynamically across development with important contributions from impulsive personality traits. This proposal will characterize the longitudinal interplay between impulsive personality traits and alcohol involvement from childhood to middle adulthood and their relation to genetic and neurobiological sources of vulnerability. By informing how genetic and neurobiological influences are associated with distinct impulsive personality trait and alcohol involvement pathways across development, this proposal may provide critical etiological insights that could ultimately improve the prevention and treatment of alcohol use disorder.

PI_NAMEs: MILLER, ALEX PARKER (contact)

PROGRAM_OFFICER_NAME: PARSIAN, ABBAS

PROJECT_TERMS: addiction;Address;Adolescence;Adult;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol exposure;alcohol involvement;alcohol use disorder;Alcohols;Amygdaloid structure;Anterior;Behavior;Biological;Brain;Brain region;career;career development;Childhood;cingulate cortex;Clinical;Complex;Corpus striatum structure;Data;Data Analyses;Data Analytics;data harmonization;Data Set;Development;disorder prevention;disorder risk;Economics;emerging adulthood;Esthesia;Etiology;European ancestry;Genetic;genetic architecture;Genetic Predisposition to Disease;genome wide association study;genome-wide;genomic data;Genomics;global health;Goals;Health Care Costs;health care disparity;health disparity;Heavy Drinking;improved;Impulsivity;Individual;innovation;insight;Intervention;Knowledge;knowledge base;Lead;life span;Link;Longitudinal cohort;Longitudinal Studies;Mediating;Methodology;middle age;Neuroanatomy;Neurobiology;neurogenetics;neuroimaging;Neurosciences;novel;older adult;Pathway interactions;Pattern;Personality Traits;Phenotype;Play;Population;Prefrontal Cortex;Prevention;Process;programs;Public Health;Research;Research Personnel;Risk Factors;Role;Sample Size;Sampling;Sampling Studies;skills;social;social factors;Source;Structure;Study models;Testing;theories;Training;Training Activity;Variant;Ventral Striatum;Work;young adult

PROJECT_TITLE: Neurogenetic influences linking impulsive personality traits and alcohol use disorder progression across development

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2 (AA)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative

ORG_CITY: STANFORD

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Many complex diseases are thought to be related with mutations in the DNA that alter the state of nearby genes. This project will develop a new strategy based on the cutting-edge AI technology to determine the functional impact of the mutations and help us to understand how DNA sequence regulates the expression of genes, and aims to apply this knowledge to investigate how mutations change gene state and contribute to disease. This project will help discover the gene regulation mechanism for complex disease and may eventually lead to the development of precise medicines.

PI_NAMEs: LIU, QIAO  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: 3-Dimensional;Acceleration;Advisory Committees;Affect;Alzheimer's Disease;Alzheimer's disease diagnosis;Artificial Intelligence;Basic Science;Biological;Biological Models;Biology;career;career development;cell type;Chromatin;Clinical;clinical care;clinical decision-making;clinical diagnostics;Clinical Pathways;Code;collaborative environment;Communities;Complex;Data;Development;Development Plans;Diagnosis;diagnostic tool;Disease;Disease Outcome;Disease susceptibility;Dissection;DNA;DNA Binding;DNA Sequence;driving force;Environment;epigenomics;Foundations;Functional Imaging;gene discovery;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic study;Genetic Transcription;genetic variant;Genome;genome wide association study;genomic data;Genomics;Genotype;Health;Human;human disease;Human Genome;Image;imaging genetics;improved;innovation;insight;interest;Knowledge;large language model;Lead;Learning;Link;Machine Learning;Mediation;Medical;Medical Imaging;Medicine;Mentors;Modernization;Mutation;Natural Language Processing;neuroimaging;novel;Nucleic Acid Regulatory Sequences;Pathway interactions;Performance;Phase;Phenotype;Professional Competence;radiomics;Research;Research Training;Resources;Scanning;self supervised learning;Signal Transduction;Site;skills;Solid;structural imaging;success;Sum;Susceptibility Gene;syntax;System;Techniques;Technology;Training;trait;transcription factor;Translating;Translations;Universities;Untranslated RNA;Validation;Variant

PROJECT_TITLE: Bridging the gap between genetic variants and radiomic phenotypes via genomic large language models

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative Understanding how inhibitory and excitation synapses function in the brain is a major first step in determining how these synapses are disrupted in neurodevelopmental disorders such as autism and schizophrenia. A better understanding of the synaptic mechanisms regulating excitatory/inhibitory balance will have the potential to direct new therapeutic strategies for management of these conditions.

PI_NAMEs: OH, WON CHAN  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Address;Affect;age related;Animal Behavior;Applications Grants;autism spectrum disorder;Brain;Calcium;Calcium Signaling;Cerebral cortex;Cognition;Communication;Data;Dendrites;Development;Disease;Down's Syndrome;Equilibrium;Excitatory Synapse;Foundations;Future;GABA Receptor;gamma-Aminobutyric Acid;Genetic;Glutamates;Goals;hippocampal pyramidal neuron;Human;Image;Impairment;in vivo;Inhibitory Synapse;insight;Interneurons;Knowledge;Long-Term Potentiation;Mediating;Modification;Molecular;Monitor;neural circuit;Neurodevelopmental Disorder;Neuronal Plasticity;Neurons;Neurotransmitters;novel;novel therapeutic intervention;Optics;optogenetics;pharmacologic;Prefrontal Cortex;Receptor Signaling;Research;Resolution;Role;Schizophrenia;Signal Transduction;Structure;Synapses;synaptic function;Synaptic plasticity;synaptic pruning;synaptogenesis;Techniques;Testing;therapeutic development;Time;two photon microscopy;two-photon;Vertebral column;Work

PROJECT_TITLE: The dual roles of GABA in excitatory synaptic plasticity

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Telehealth;Women's Health Research

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative Fear of cancer progression (FOP) is the most common concern and unmet need in patients with advanced cancer. The “Day by Day” is a blended e-Health intervention for managing FOP, consisting of group and on-line self-study sessions. The intervention is tailored to patients with advanced cancer. Use of a videoconferencing approach is scalable and can increase access to psychosocial support services, especially in community and underserved settings.

PI_NAMEs: REB, ANNE  (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: acceptability and feasibility;Address;Advanced Malignant Neoplasm;Anxiety;Belief;biological adaptation to stress;Cancer Patient;Cancer Survivor;Clinic Visits;Clinical Trials;Collaborations;Communities;community organizations;Data;design;Disease;Distress;Dropout;Education;Educational process of instructing;Effectiveness;eHealth;Eligibility Determination;Emotional;Enrollment;Evaluation;experience;feasibility testing;flexibility;Fostering;Fright;Future;Goals;Gynecologic;Health Care Costs;Health Personnel;Health Services Accessibility;healthy lifestyle;interdisciplinary approach;Intervention;Learning;Lung;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Mental Depression;Mental Health;metacognition;mindfulness;Modeling;Monitor;new therapeutic target;novel;Nurses;Online Systems;Participant;participant enrollment;Patients;peer support;Physically Challenged;Pilot Projects;post-traumatic symptoms;primary outcome;Problem Solving;Provider;Psychologist;psychosocial;Psychosocial Assessment and Care;Questionnaires;Randomized;randomized trial;Recurrence;Reporting;Research;Research Priority;Resources;response;rural setting;Services;Site;skills;Social Workers;Structure;Support Groups;Surveys;Survival Rate;Survivors;symptom management;Symptoms;Technology;Testing;Therapeutic;Time;Training;treatment arm;treatment as usual;treatment duration;Treatment/Psychosocial Effects;tumor progression;Uncertainty;underserved community;uptake;urban setting;usability;usual care arm;Videoconferencing;Visit;web site;Well in self;Woman;Work

PROJECT_TITLE: A Blended e-Health Intervention for Fear of Progression in Advanced GYN Cancer

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Acute respiratory distress syndrome (ARDS) is present in over 10% of all patients admitted to intensive care units worldwide and is associated with high mortality (30-40%). Despite the absence of effective pharmacotherapies addressing underlying mechanisms of ARDS, findings from the COVID-19 research landscape suggest treatment strategies that merit deeper exploration. CD14-blockade with the monoclonal antibody IC14 demonstrated on target bio-efficacy signals in severe COVID-19, and further study of CD14 blockade in ARDS is warranted to understand the potential of this treatment strategy for mitigating lung and systemic immunopathology and improving patient outcomes in ARDS.

PI_NAMEs: MABREY, FRANCES LINZEE (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Address;Affect;Alveolar;Applications Grants;Biological;Biological Markers;Biological Response Modifiers;biomarker driven;biomarker evaluation;biomarker identification;Biostatistical Methods;Blood;Bronchoalveolar Lavage Fluid;career development;Cell membrane;cell type;Cells;cellular targeting;Clinical;clinical biomarkers;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;Complement;Conduct Clinical Trials;COVID-19;COVID-19 pneumonia;COVID-19/ARDS;Critical Illness;Data;Data Set;design;Development;Development Plans;differential expression;Elements;Enrollment;Epidemiology;Evaluation;Exhibits;feasibility testing;Functional disorder;Funding;Future;Genes;Goals;high dimensionality;Hypoxemic Respiratory Failure;Immune;immune modulating agents;Immune response;immunopathology;improved;improved outcome;indexing;Infection;Inflammation;inflammatory marker;inflammatory milieu;Inflammatory Response;Infrastructure;Innate Immune Response;instrument;Intensive Care Units;Intervention;Intervention Trial;Investigation;Lead;Leukocytes;Liquid substance;Lung;lung injury;Measurement;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Molecular;Monoclonal Antibodies;mortality;Natural Immunity;novel;novel marker;novel therapeutic intervention;Observational Study;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Patient Admission;patient subsets;Patient-Focused Outcomes;Patients;Permeability;Pharmacodynamics;pharmacologic;Pharmacotherapy;Phase;Phase II Clinical Trials;pilot trial;Plasma;Play;Population;precision medicine;Prediction of Response to Therapy;Process;prognostic;prognostic value;programs;randomized trial;Randomized, Controlled Trials;Research;Research Personnel;respiratory;Respiratory System;response;Role;Sampling;Scientist;secondary endpoint;severe COVID-19;Severities;Signal Transduction;single-cell RNA sequencing;skills;Stratification;Subgroup;Testing;Therapeutic;Therapeutic Effect;Therapeutic Studies;therapeutic target;tissue injury;TNF gene;Training;transcriptome sequencing;translational approach;translational physician;Translational Research;treatment response;treatment strategy;trend

PROJECT_TITLE: Targeting CD14: A Novel Therapeutic Approach for Acute Respiratory Distress Syndrome

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (MA)]


ORG_CITY: HOUSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Hypertension is the major clinical problem in the US and worldwide with kidneys playing a central role in regulation of systemic sodium balance and blood pressure control. In this proposal, we identified a novel signaling factors, specifically Epac1 and Epac2, determining how kidneys regulate sodium balance. We further provided initial experimental support that our recently developed blockers of Epacs could be beneficial in reducing blood pressure and promoting sodium excretion in animal models of hypertension.

PI_NAMEs: CHENG, XIAODONG ;POCHYNYUK, OLEH  (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: absorption;Address;Adverse effects;Animal Model;Anti-Hypertensive Agents;Automobile Driving;Binding;Biological Availability;Biology;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure reduction;Body Water;Clinical;clinically significant;Collaborations;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Development;Diet;dietary;dietary salt;Diuretics;drug discovery;Duct (organ) structure;Electrolytes;Electrophysiology (science);epithelial Na+ channel;Epithelium;Equilibrium;Excretory function;Exhibits;fighting;G-Protein-Coupled Receptors;Genes;Genetic Models;Homeostasis;Hormones;Human;Hydrogen;hyperkalemia;Hypertension;hypertension treatment;hypertensive;Hypotension;Hypotensives;Hypovolemia;Hypovolemics;Imaging Device;Impairment;improved;in vivo;Individual;inhibitor;Intake;Kidney;Laboratories;Link;membrane activity;Mitochondria;Molecular;Molecular Target;mouse model;Mus;Natriuresis;Nephrons;novel;Ontology;Oxidative Stress;Pathology;Pathway interactions;Pattern;pharmacologic;Pharmacology;Phenotype;Physiological;Physiology;Pilot Projects;Play;Preparation;Process;Production;Protein Isoforms;Proteins;Publishing;Reactive Oxygen Species;Regulation;Renal function;Renal tubule structure;response;Rodent;Rodent Model;Role;salt balance;salt intake;saluretic;Scheme;Signal Transduction;small molecule;Sodium;Sodium Chloride;sodium-hydrogen exchanger 3;synergism;System;Testing;therapeutic target;therapeutically effective;tool;Toxic effect;transcriptome sequencing;Tubular formation;urinary;Variant;Water

PROJECT_TITLE: Significance of Epac signaling in renal Na+handling and hypertension

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

PHR: Patients with respiratory disease are frequently referred for pulmonary consultation, but access to pulmonologists is often insufficient to meet demand. To address this challenge, the VA uses “e-consults” which allow primary care providers to get rapid advice from pulmonologists through the electronic health record. This approach to coordinating patient care can improve timeliness and efficiency, though there are also concerns that it could adversely affect patient and provider relationships and the quality of communication. In the proposed research, I will explore these potential unintended consequences and identify best practices to support high quality e-consult coordination. I will use this information to design, implement, and test an E- consult First intervention, in which all pulmonary consult requests are first entered as e-consults. I will assess the impact of the intervention on diverse outcome measures. This research has the potential to improve the quality of e-consult coordination, which could lead to systems that offer more timely specialty care.

PI_NAMEs: RINNE, SEPPO T (contact)

PROJECT_TERMS: Address;Affect;Applied Research;Board Certification;care delivery;career;career development;Caring;Chronic Obstructive Pulmonary Disease;Cladribine;Clinical;Communication;Consensus;Consult;Consultations;Deimplementation;Delphi Technique;design;Development Plans;Doctor of Philosophy;effectiveness/implementation hybrid;Electronic Health Record;Electronics;Elements;Environment;Evidence based practice;experience;Focus Groups;Goals;health care delivery;health care service organization;health communication;Health Services;Health system;Homogeneously Staining Region;implementation efforts;implementation evaluation;implementation framework;implementation outcomes;implementation research;implementation science;implementation strategy;improved;Individual;Influentials;Informatics;insight;Interpersonal Relations;Interruption;Intervention;intervention effect;Interview;Knowledge;Lung;medical specialties;Mentors;Methods;Modeling;multidisciplinary;novel;Outcome;Outcome Measure;Pathway Analysis;Patient Care;Patients;Pharmaceutical Preparations;Positioning Attribute;primary care provider;Process;programs;Provider;provider communication;Published Comment;Quality of Care;Recommendation;Research;Research Personnel;Resources;Respiratory Disease;Role;satisfaction;Scientific Advances and Accomplishments;Site;skills;Social Network;Specialist;Structure;Surveys;System;Testing;theories;Time Series Analysis;Training;Update;Veterans;Visit;Wait Time;Work;Writing

PROJECT_TITLE: Applying Relational Coordination to Implement a Pulmonary E-consult Intervention

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE  Breast cancer is the most diagnosed cancer in the world and imposes a large public health burden, where much of this burden can be attributed to metastasis. The experiments described herein will elucidate the roles of coamplified genes in HER2+ breast cancer metastasis. Results from this proposal will provide a greater mechanistic understanding of the metastatic cascade, prognostic indicators of metastasis, and determination of genes that are necessary or sufficient to increase metastasis.

PI_NAMEs: BROEKER, CARSON DENNIS (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: 17q21;Address;Affect;arm;Automobile Driving;Binding;Biological Assay;breast cancer metastasis;Breast Cancer Patient;cancer diagnosis;Candidate Disease Gene;Cause of Death;Cell Line;cell motility;Cell Survival;Cells;chemotherapy;Chromosome 17;Chromosomes;Clinical;Co-Immunoprecipitations;Collagen;Collagen Gene;Collagen Type I;Data;Dependence;Distant;driving force;Epidermal Growth Factor Receptor;Epithelial Cells;ERBB2 gene;Evaluation;Event;Exhibits;experimental study;extracellular;Extracellular Matrix;Extravasation;Failure;Family;Future;Gene Dosage;Gene Expression;Gene Expression Profiling;Gene set enrichment analysis;Genes;Genetic;genome sequencing;genomic data;Genomics;Goals;Human;Human Cell Line;Human Characteristics;Human Chromosomes;Immunocompromised Host;Immunohistochemistry;Immunoprecipitation;improved;In Situ Nick-End Labeling;in vivo;Individual;Injections;Integrins;knock-down;Knock-out;Knowledge;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;mammary tumor virus;MAP Kinase Gene;Measures;Mediating;MEKs;Methods;migration;Modeling;Molecular;Monoclonal Antibodies;mortality;Mouse Cell Line;Mouse Mammary Tumor Virus;mouse model;Mus;Neoplasm Metastasis;Oncogenic;Outcome;overexpression;Paper;Pathway interactions;Patients;Phenotype;Preclinical Testing;Primary Neoplasm;prognosis biomarker;prognostic indicator;prohibitin;Proliferating;promoter;Protein Isoforms;protein protein interaction;Proteins;Public Health;Ras/Raf;Rattus;Receptor Protein-Tyrosine Kinases;relapse risk;Research;Role;Sampling;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Stains;targeted treatment;Testing;The Cancer Genome Atlas;transcriptomics;Transgenic Mice;tumor;tumor microenvironment;Tyrosine Kinase Inhibitor;Up-Regulation;whole genome;women's diagnosis;Women's mortality

PROJECT_TITLE: Conserved coamplification event in HER2+ breast cancer increases metastasis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative  Over 40% of adults in the USA are classified as overweight or obese and there is currently a shortage of effective treatments to reduce the excessive food intake that can lead to obesity. Novel and effective obesity prevention and treatment strategies are aided by basic science research identifying specific brain chemical systems that reduce food intake. A novel approach is taken here; we are investigating the extent to which factors including sex and social context modulate the effects of oxytocin, a neuropeptide with clinical relevance to human obesity treatment, on food intake regulation.

PI_NAMEs: REA, JESSICA  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Adult;Affect;Animal Model;Animals;Basic Science;Behavior;Behavioral;Behavioral Mechanisms;Body Weight decreased;Brain;brain pathway;Brain region;Chemicals;Classification;Clinical;Clinical Trials;clinically relevant;Consumption;Cues;Data;Development;Dopamine;dopamine system;Dorsal;Eating;Eating Behavior;effective therapy;experimental study;Exposure to;Familiarity;feeding;Feeding behaviors;Female;Fiber;Food;food consumption;food environment;Food Intake Regulation;Food Preferences;G-Protein-Coupled Receptors;Hippocampus;Home;Human;Hypothalamic structure;Image;in vivo imaging;Individual;Intake;interest;Intranasal Administration;Investigation;knock-down;Knowledge;lateral ventricle;Learning;Link;Literature;male;Maternal Behavior;Mediating;Memory;Modeling;motivated behavior;neural;Neural Pathways;Neuroanatomy;neuromechanism;Neuropeptides;Neurotransmitters;novel;novel strategies;Obesity;obesity prevention;obesity treatment;Overweight;Oxytocin;Oxytocin Receptor;Paper;paraventricular nucleus;Participant;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Photometry;Physiological;Play;Prevention strategy;Procedures;Process;Rattus;Receptor Signaling;reduced food intake;Regulation;Research;reward circuitry;Rodent;Rodent Model;Role;sensor;sex;sexual dimorphism;Signal Transduction;Site;skills;social;Social Behavior;Social Controls;Social Environment;social factors;social influence;social learning;supraoptic nucleus;System;Therapeutic;transmission process;treatment strategy;Viral;Weight;Work

PROJECT_TITLE: Investigating the role of oxytocin signaling in the social regulation of eating


NIH_SPENDING_CATS: Breast Cancer;Cancer;Hematology;Immunotherapy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Altered hematopoiesis and myeloid biased skewing promotes the expansion of immune suppressive myeloid populations, a phenomenon that is observed in cancer patients regardless of the tumor type and/or dissemination to bone. Currently, the impact of a primary tumor on bone marrow hematopoietic stem and progenitor cells (HSPCs), as well as the factors involved in changing their frequency and/or functionality, remain unclear. The aims proposed here will broaden our understanding of the effects of tumor progression on hematopoiesis and, importantly, the role of the bone in generating the immune suppressive environment.

PI_NAMEs: EUL, EMILY M (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: 4T1;anti-tumor immune response;beta catenin;Bioinformatics;Biological Assay;Biology;bone;bone cell;Bone Marrow;Bone Marrow Transplantation;Bone neoplasms;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;Breeding;Bypass;Cancer Patient;cancer type;career;Cell Separation;Cells;Circulation;Colony-Forming Units Assay;Color;Communication;Complex;Development;Disease Progression;effective therapy;Environment;EO771;experience;experimental study;Female;Flow Cytometry;Fostering;Frequencies;Generations;Genetic;Goals;Grant;granulocyte;Hematology;Hematopoiesis;hematopoietic stem cell self-renewal;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Human;Immune;Immune Evasion;Immune response;Immune system;Immunoglobulin G;Immunologic Surveillance;Immunology;immunoregulation;Immunotherapy;improved;inhibitor;Injections;interest;irradiation;Knowledge;Laboratories;Lymphopoiesis;Malignant Breast Neoplasm;Modeling;monocyte;Mouse Mammary Tumor Virus;mouse model;Mus;Myelogenous;Myelopoiesis;Natural Killer Cells;neoplastic cell;neutralizing antibody;novel;Osteoblasts;Output;overexpression;Play;polyoma middle tumor antigen;Population;Primary Neoplasm;Prognosis;Proliferating;Property;Proteins;reconstitution;Regulation;Research;Role;Sampling;single-cell RNA sequencing;Site;skills;Source;stem cell exhaustion;T-Lymphocyte;Testing;Time;Training;training opportunity;transcriptome;transplant model;tumor;tumor growth;tumor immunology;tumor progression;Tumor Promotion;Tumor stage

PROJECT_TITLE: Regulation of hematopoiesis during tumor progression


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Microbiome

ORG_CITY: IOWA CITY

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The oral cavity is a complex environment where a diverse array of organisms coexists in dynamic interplay with the human immune system. While bacteria and fungi have traditionally been the focus of research on the human microbiome, recent studies have highlighted the significant role of phages (viruses infecting bacteria) in shaping the oral microenvironment. Our proposal aims to re-examine the large set of existing metagenomic data to comprehensively investigate the role of the oral virome and its interactions with the microbiome which will help us to understand the intricate dynamics of the oral microenvironment; ultimately inspiring new approaches to promote oral health and prevent/manage oral diseases more effectively.

PI_NAMEs: DABDOUB, SHAREEF MAJED (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: 16S ribosomal RNA sequencing;Affect;Algorithms;Antibiotics;Archaea;Area;Bacteria;Bacteriophages;Behavior;cancer therapy;Carbon;Cells;co-infection;Collaborations;Communities;Complex;cost;Cytolysis;Cytomegalovirus;Data;data mining;Data Set;Development;Disease;DNA;DNA Databases;Ecology;Environment;Exhibits;Foundations;fungus;Future;Gene Transfer;Genes;Health;Health Status;Herpesviridae;High Performance Computing;High-Throughput Nucleotide Sequencing;Human;Human Herpesvirus 4;Human Microbiome;Human Papillomavirus;Immune system;Infection;Inflammatory;innovation;Light;Maintenance;malignant mouth neoplasm;member;Metabolic;Metabolism;Metadata;Metagenomics;metatranscriptome;metatranscriptomics;microbial;microbial composition;microbial genome;microbiome;microbiome research;Modernization;Mouth Diseases;Mucositis;multiple omics;neglect;Nitrogen;novel strategies;oceanic research;Oceans;Oral;Oral cavity;Oral Examination;Oral health;oral microbiome;Organism;pathogenic virus;Pathway Analysis;Periodontal Diseases;Photosynthesis;Planet Earth;Play;Population;Positioning Attribute;prevent;Process;Publications;Publishing;PubMed;Research;Research Personnel;Resources;RNA;Role;secondary analysis;Shapes;Soil;Statistical Data Interpretation;System;Technology;tool;transcriptomics;Viral;Viral Genome;virome;Virus

PROJECT_TITLE: Integrated computational approaches to determine contributions of the oral virome

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 CC (13)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PHILADELPHIA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative  This research will focus on studying the dynamic behavior of the alkyl radical generated via CN bond breaking of a pyridinium salt and using this information to develop new nickel-catalyzed transformations utilizing alkyl radicals in three-component reactions. Multicomponent reactions can rapidly build a complex molecular scaffold with applications in optimizing organic syntheses for drug discovery. The streamlining of organic syntheses from multistep processes to shorter, nickel-catalyzed reactions will lead to lower drug cost and an increase in the accessibility of these compounds for the public.

PI_NAMEs: ROTELLA, MADELINE  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Molecular Dynamics Investigation of the Reactivity of Alkyl Radicals in Transition Metal-Catalyzed Transformations

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-A (KR)]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: WASHINGTON

ORG_NAME: ASSOCIATION/OCCUPATIONAL & ENVIR CLINICS

ORG_STATE: DC

PHR: The primary goal of the OHIP program is to identify and provide training for the next generation of occupational health professionals. The second goal of OHIP is to increase diversity in the occupational health disciplines by aggressively recruiting and mentoring students from minority and immigrant backgrounds.

PI_NAMEs: HARRISON, ROBERT J (contact)

PROGRAM_OFFICER_NAME: MAPLES, ELIZABETH

PROJECT_TITLE: Occupational Health Internship Program (OHIP)

STUDY_SECTION_NAME: Special Emphasis Panel[ZOH1 DVN (03)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health and to NIAID’s mission to support basic and applied research to better understand and treat infectious, immunologic, and allergic diseases because it will elucidate new fundamental human immunobiology that is likely to inform the development of immune therapies to combat HIV persistence. The results also have potential to inform immune therapies for other persistent infections, cancers, transplantation, and autoimmunity that affect millions of individuals worldwide.

PI_NAMEs: COLLINS, DAVID RANDOLPH (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Adherence;Affect;Allergic Disease;Antigens;antiretroviral therapy;Applied Research;Area;Autoimmunity;Autologous;Basic Science;Biology;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cell Physiology;Cell surface;Cell Surface Receptors;Cells;Cellular Immunity;Cellular Immunology;chronic infection;Circulation;Clinical;Collaborations;combat;Communicable Diseases;Data;Defect;defined contribution;Detection;Development;Disease Progression;disease transmission;Epigenetic Process;Epitopes;exhaustion;Failure;Frequencies;Functional disorder;Functional impairment;Genes;Goals;HIV;HIV Infections;Human;human disease;Immune;immune clearance;Immune Evasion;Immune response;Immune System Diseases;Immunobiology;Immunotherapy;Impairment;improved;Individual;Infection;innovation;Knowledge;Laboratories;Lymphoid Tissue;Maintenance;Malignant Neoplasms;Mediating;Mission;Modality;Molecular;Molecular Virology;monocyte;multiple omics;Mutation;National Institute of Allergy and Infectious Disease;novel;Pathway interactions;Peripheral;Persons;Phorbol Esters;Postdoctoral Fellow;prevent;Process;Public Health;receptor;receptor expression;Receptor Signaling;Refractory;Research;Resolution;Role;Specimen;T-Cell Activation;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Techniques;Training;Transplantation;Viral;Viral reservoir;Viremia;Virus;Virus Latency

PROJECT_TITLE: Modulating T Cell Activation to Combat HIV Persistence

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 VSR-D (M1)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biotechnology;Neurosciences

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE  It is known that blood-brain barrier function declines with aging, but the effects of aging on the choroid plexus, a key component of the blood-brain barrier that transports molecules between the blood and cerebrospinal fluid, are largely unknown. Measuring the extent to which blood-to-brain protein transport in the choroid plexus is altered in aging would reveal which transporters are best targeted as drivers of brain aging or as drug delivery vehicles. This proposal describes using novel mass spectrometry-based proteomic technologies to measure how the kinetics of translocation of transporters and cargo in the choroid plexus change with aging.

PI_NAMEs: SHUKEN, STEVEN ROBERT (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Acids;Age;age effect;age-related disease;aged;Aging;aging brain;aging related;aging related disease;anti aging drug;Bar Codes;Behavior;Biological;Biology;Biotin;Blood;Blood - brain barrier anatomy;blood cerebrospinal fluid barrier;Blood Circulation;Blood Proteins;blood-brain barrier function;Brain;career;Carrier Proteins;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Chemicals;Chemistry;Choroid Plexus Epithelium;Data;data library;deep learning;delivery vehicle;Detection;Diffusion;Drug Delivery Systems;Ensure;Epithelial Cells;Event;experimental study;flexibility;Foundations;Functional disorder;functional group;Future;Goals;in vivo;innovation;interest;Investigation;Journals;Kinetics;Label;Libraries;Lipoproteins;Manuals;Manuscripts;Mass Spectrum Analysis;Measures;Membrane Proteins;Methods;Modification;Monitor;Movement;Mus;Neurodegenerative Disorders;new therapeutic target;next generation;novel;old mice;Pathway interactions;Penetration;Peptides;Performance;Pharmaceutical Preparations;Plasma;Plasma Proteins;Protein translocation;protein transport;Proteins;Proteome;Proteomics;Publishing;Reaction;Reagent;Recombinant Proteins;Recombinants;Reproducibility;Research;Research Personnel;Running;Sampling;Somatomedins;Streptavidin;Structure of choroid plexus;Structure of choroid plexus of lateral ventricle;success;Surface;Technology;Testing;therapeutic candidate;therapeutic target;Time;transcytosis;Transferrin;Transport Process;Validation;Work

PROJECT_TITLE: Validation and Kinetic Characterization of Blood-Cerebrospinal Fluid Barrier-Traversing Proteins in Aging With Library-Free Multiplexed Targeted Proteomics

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PHR: PROJECT NARRATIVE Although medications such as buprenorphine and methadone are known to be effective at treating opioid use disorder (OUD), segregation and structural racism are likely to influence treatment outcomes among pregnant people with OUD in the United States. In the proposed study, I will link administrative claims data from pregnant patients prescribed these drugs to individual area-based data and investigate how social structures affect OUD treatment outcomes. Consistent with the NIDA Racial Equity Initiative Action Plan’s goals of advancing understanding of social determinants of health to guide future intervention development, this work has high potential for impact by generating novel data on the influence of structural racism on treatment outcomes and informing policymakers aiming to develop data-driven interventions to reduce overdose in locations of greatest risk.

PI_NAMEs: XU, KEVIN YOUNG (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: addiction;Address;Affect;Area;Award;Big Data;black patient;Black Populations;Black race;Buprenorphine;buprenorphine treatment;career;career development;Characteristics;Clinical;Communities;compare effectiveness;Data;Data Science;Dedications;deprivation;Disadvantaged;Disparity;drug abuse prevention;Drug Prescriptions;Effectiveness;Equity;experience;Funding;Future;Geography;Goals;health equity;Health equity research;improved;indexing;Individual;interest;intersectionality;Intervention;Knowledge;Link;Location;Measures;Mediating;Mediation;Medicaid;Medicaid services;Mentorship;Methadone;methadone clinic/center;methadone treatment;Methods;National Institute of Drug Abuse;Nature;Neighborhoods;Not Hispanic or Latino;novel;opioid epidemic;opioid overdose;opioid use disorder;outcome disparities;outreach;Overdose;overdose death;Overdose reduction;overdose risk;Patients;Pattern;peer;Perinatal;personalized approach;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Physicians;Policy Maker;Poverty;Pregnancy;Pregnancy Complications;pregnant;prevent;preventable death;protective effect;Proxy;Psychiatry;psychosocial;Public Health;Race;racial disparity;Racial Equity;racial population;Racial Segregation;Research;Research Personnel;research study;residential segregation;Risk;segregation;social;social deprivation;social health determinants;social structure;socioeconomics;Structural Racism;System;Testing;Theoretical model;therapy development;tool;Training;Treatment Effectiveness;treatment optimization;Treatment outcome;Underrepresented Populations;United States;United States Centers for Medicare and Medicaid Services;uptake;waiver;Work

PROJECT_TITLE: Using Big Data to Optimize Treatment of Opioid Use Disorder in Pregnancy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE Anthropogenic climate change is expected to have significant consequences for the health and wellbeing of affected populations, especially in lower- and middle-income settings. We use demographic and health surveys from Indonesia and Mexico, combined with high-resolution climate records, to measure the effects of climate exposures during early childhood and adolescence on the fertility, health, migration, and socioeconomic statuses of working-age adults.

PI_NAMEs: THIEDE, BRIAN  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Affect;Age;age difference;aged;anthropogenesis;Area;Attention;Biological Factors;Birth;Body mass index;Characteristics;Child;Childhood;Climate;climate change;climate data;climate impact;climate variability;climate-related exposures;cohort;Consumption;cost;Country;critical period;Data;Data Set;Demographic and Health Surveys;Development;diarrheal disease;Dimensions;Droughts;early adolescence;early childhood;Economic Conditions;economic outcome;Education;environmental stressor;expectation;Expenditure;Exposure to;Family Life Surveys;Fertility;Floods;Future;Genetic Complementation Test;global health;Health;health determinants;health economics;Heterogeneity;Human;in utero;Income;Individual;Indonesia;Inequality;insight;Interview;Knowledge;late life;Life;Life Cycle Stages;Link;Literature;Long-Term Effects;Malnutrition;Measures;Mexican;Mexico;migration;Modeling;mortality;older adult;Older Population;Outcome;Pattern;Personal Satisfaction;Phase;Population;Poverty;Precipitation;Recording of previous events;Records;Research;residence;Resolution;Resources;Rural;rural area;Sampling;Series;sex;Shapes;Shock;skills;social;social factors;social vulnerability;Socioeconomic Status;socioeconomics;Statistical Data Interpretation;Stress;Temperature;Testing;Time;urban area;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Demographic and Health Effects of Climate Exposures Across the Life Course

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Cardiovascular;Emerging Infectious Diseases;Heart Disease;Infectious Diseases;Prevention

PHR: PROJECT NARRATIVE Infections following the implantation of cardiac implantable electronic devices (CIEDs) are major complications associated with significant morbidity, mortality, rehospitalizations, and increased medical costs. These infections persist despite current antibiotic treatments and preventive measures, primarily due to biofilm formation on CIEDs and the increasing prevalence of multidrug-resistant bacteria. In this application, we aim to investigate the potential of a cutting-edge antimicrobial blue light (aBL) emitting envelope (aBL-ENV) to reduce the risk of CIED infections. aBL-ENV emits aBL uniformly across its entire surface to prevent biofilm formation and eradicate existing biofilm on aBL-ENV/CIED. Successful execution of the studies detailed in this application will provide the preclinical evidence required to evaluate the effectiveness and safety of aBL-ENV, and will showcase the functionality of a prototype system of aBL-ENV.

PI_NAMEs: DAI, TIANHONG  (contact);MELA, THEOFANIE

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Adverse effects;Affect;Aftercare;Animals;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Resistance;Arrhythmia;Attention;Bacteria;Bacterial Infections;Biocompatible Materials;carcinogenicity;cardiac implant;Clinical;Colony-forming units;combat;cytokine;cytotoxic;Development;dysbiosis;Effectiveness;effectiveness evaluation;Electronics;Electrons;Escherichia coli;Euthanasia;Exhibits;field study;Growth;Heart failure;Histology;hospital readmission;implantation;improved;In Vitro;in vivo;Incidence;Infection;Inflammatory;Inflammatory Response;innovation;Laboratories;Life;Light;light emission;Measures;Medical Care Costs;Microbial Biofilms;microscopic imaging;Modeling;Morbidity - disease rate;mortality;Multiple Bacterial Drug Resistance;Nonpharmacologic Therapy;novel;operation;Optics;Oryctolagus cuniculus;pathogen;Patients;Phototherapy;Porphyrins;pre-clinical;Prevalence;prevent;Preventive measure;Protocols documentation;prototype;Pseudomonas aeruginosa;Reactive Oxygen Species;Reporting;Resistance development;Resistance profile;Risk Reduction;Safety;safety assessment;Scanning;Staphylococcus aureus;Staphylococcus epidermidis;Surface;Suspensions;System;Technology;Testing;Time;Tissues;wireless

PROJECT_TITLE: Antimicrobial Blue Light Emitting Envelope for the Control of Cardiac Implantable Electronic Device Infections

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE The development of strong writing skills is critical for early-stage investigators is vital for successful careers in biomedical science, however, evidence-based training and mentoring models to develop these skills are absent in the scientific literature. We propose to conduct randomized controlled trial with120 early-stage investigators from backgrounds underrepresented in biomedical science to test the efficacy of refined, mentored scientific manuscript writing interventions on manuscript submission, publications, and persistence.

PI_NAMEs: BEECH, BETTINA M. (contact);BRUCE, MARINO A;THORPE, ROLAND J.

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Academia;Acceleration;Accountability;Achievement;Applications Grants;Authorship;Biomedical Research;Black race;career;Development;Disparity;efficacy evaluation;efficacy testing;evidence base;expectation;Extramural Activities;Faculty;Funding;gender disparity;Goals;Graduate Education;Habits;Health;improved;Individual;Institution;Intervention;intervention cost;Journals;Knowledge;Learning;Literature;Manuscripts;Measures;Mentors;Modeling;Motivation;Outcome;Outcome Assessment;Participant;peer;Peer Review;phrases;Pilot Projects;Positioning Attribute;primary endpoint;Productivity;programs;Publications;Publishing;racial disparity;Randomized;randomized trial;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Respondent;response;satisfaction;Schools;Science;Scientist;secondary endpoint;Self Efficacy;skills;Structure;success;Testing;theories;therapy design;Training;Underrepresented Populations;United States National Institutes of Health;virtual;virtual group;Writing

PROJECT_TITLE: Write From The Start

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-W (RI)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Kidney Disease;Patient Safety;Precision Medicine

ORG_CITY: SAN FRANCISCO

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

PHR: PROJECT NARRATIVE Kidney complications occur commonly during heart failure treatment and strongly influence treatment decisions. However, current methods for monitoring kidney health are suboptimal. This proposal will develop a panel of kidney health biomarkers that could enable kidney-safe, effective treatment of heart failure.

PI_NAMEs: ESTRELLA, MICHELLE M (contact);TESTANI, JEFFREY M

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute;Address;Adult;Adverse event;adverse outcome;Affect;Albuminuria;Biological Markers;biomarker panel;Body Weight Changes;cardiovascular health;Caring;Clinical;clinical care;Clinical Data;clinical decision-making;clinical prognostic;Clinical Trials;cohort;Collection;common treatment;Congestive Heart Failure;cost;Creatinine;diagnostic strategy;Dimensions;Discharge Plannings;Diuresis;Diuretics;Dose;effective therapy;effectiveness evaluation;Fibrosis;follow-up;Foundations;Fright;Goals;Guidelines;Health;Health Status;Heart failure;hemodynamics;high risk;HIV Infections;hospital readmission;Hospitalization;Hospitals;Hour;Hypertension;Impairment;improved;Individual;individual patient;individualized medicine;Inflammation;Injury;Injury to Kidney;Kidney;Left;Life;Measures;Medical;Methods;Monitor;mortality;mortality risk;Natriuresis;Natriuretic Peptides;Nephrons;novel diagnostics;Oral;Outcome;Patient Discharge;patient response;Patients;Pattern;Persons;Pharmacological Treatment;Physiological;predicting response;Prediction of Response to Therapy;Prognosis;prognostic tool;prognostication;Readiness;reduce symptoms;renal damage;Renal function;Renal tubule structure;reparative capacity;Residual state;Resistance;Resort;response;Risk;risk minimization;Role;Safety;saluretic;Selection for Treatments;Serum;Severities;Testing;Therapeutic;Thiazide Diuretics;tissue injury;tool;Treatment Efficacy;Treatment Failure;treatment response;treatment strategy;Tubular formation;Visit;Work

PROJECT_TITLE: Advanced Kidney Health Monitoring in Persons Hospitalized with Heart Failure

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Genetics;Kidney Disease

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Injury to the kidneys due to a short-term loss of blood supply is a common problem affecting hospitalized patients, but it lacks any specific treatment. The goal of this project is to better understand how the genes that determine the ways kidney cells use energy are controlled because these processes make the kidney vulnerable to injury. This understanding may lead to ways to prevent and treat kidney injury.

PI_NAMEs: BEAMISH, JEFFREY ALAN (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Affect;Award;Binding;Carbon;Cell Respiration;Cells;Chromatin;Clinical;clinical practice;cost;Data;Development;DNA Binding;Epithelium;experimental study;fatty acid metabolism;Foundations;Freezing;Genes;Genetic;Genetic Determinism;Genetic Enhancer Element;Genetic Transcription;Goals;Hemorrhage;HNF4A gene;Hospitalization;in vivo;Injury;Injury to Kidney;Ischemia;ischemic injury;Kidney;kidney cell;kidney cortex;Measures;Mediating;Metabolic;Metabolic Pathway;metabolic profile;Metabolism;metabolomics;Michigan;mitochondrial dysfunction;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;mutant;Nephrons;new therapeutic target;novel;Pathogenesis;Pathway interactions;Patients;Pattern;Population;prevent;Process;programs;Recommendation;Regulation;renal ischemia;Reperfusion Injury;Research;Research Support;Resistance;response;Risk;risk stratification;Role;Sampling;Site;solute;Specificity;Syndrome;Testing;Text;Tissue Sample;tool;Toxic effect;transcription factor;transcriptome;transcriptomics;Universities;Vascular blood supply

PROJECT_TITLE: Pax8-Hnf4a co-regulation in ischemic kidney injury

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BOSTON

PHR: This project explores the underlying mechanisms of Frontotemporal Dementia (FTD) by employing advanced technology for neuronal activity monitoring and manipulation. These experiments will determine how different neuron-type-specific interventions affect the progression of FTD pathology and behavioral deficits. This insight will inform the development of therapies to modulate neuronal excitability, potentially leading to the discovery of new therapeutic strategies.

PI_NAMEs: ALGAMAL, MOUSTAFA  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Address;Affect;Age;age effect;Aging;ALS pathology;ALS patients;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Anesthesia procedures;Animal Model;Appearance;Applications Grants;awake;Award;Behavior;behavior change;Behavioral;behavioral phenotyping;brain tissue;C9ORF72;Calcium;career;career development;cell type;Chronic;Cognitive deficits;collaborative environment;comorbidity;Complement;Cytoplasmic Inclusion;Data;design;Development;Development Plans;Dipeptides;Disease Progression;Educational workshop;effective therapy;electrical measurement;Electrophysiology (science);Ensure;Environment;Equilibrium;experimental study;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;General Hospitals;Genes;Genetic;genetic approach;Goals;Grant;Hyperactivity;Image;imaging study;in vivo;Individual;insight;Intervention;Knowledge;Knowledge acquisition;Laboratories;Leadership;Learning;Manuscripts;Massachusetts;Measures;medical schools;meetings;Mentors;Mentorship;Modeling;Monitor;Motor Neuron Disease;mouse model;multi-photon;multiphoton imaging;multiphoton microscopy;Mus;Neurodegenerative Disorders;neuron loss;neuronal excitability;Neurons;neuropathology;novel therapeutic intervention;Nuclear RNA;old mice;Onset of illness;optogenetics;Pathologic;Pathology;Patients;Personality;Phenotype;Placebos;programs;protein TDP-43;Proteins;Proxy;Reporting;Research;Research Personnel;Research Project Grants;Resources;RNA;serial imaging;skill acquisition;skills;symposium;Teaching Hospitals;Technology;Testing;therapy development;tool;Training;Validation

PROJECT_TITLE: Understanding the relationship between cortical hyperexcitability and the progression of FTD/ALS pathology and behavioral deficits in mice


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Diabetes;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Nutrition;Obesity;Prevention

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Erythritol, an artificial sweetener that is also endogenously produced, has been linked to heart disease. This proposal seeks to determine the association of erythritol and its metabolites to vascular disease and heart failure risk in a multi-ethnic population and assess erythritol and erythronate production in people with and without type 2 diabetes and/or obesity when fasting and in response to oral glucose and erythritol.

PI_NAMEs: ABUSHAMAT, LAYLA A (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, JEAN M

PROJECT_TERMS: Adult;Advisory Committees;Artificial Sweeteners;Atherosclerosis;Atherosclerosis Risk in Communities;Biological;Biological Markers;Biometry;Board Certification;Body mass index;Cardiometabolic Disease;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;career development;Cessation of life;clinical investigation;clinical predictors;Clinical Research;college;Coronary heart disease;Data;Diabetes Mellitus;Diagnosis;dietary;Dietary intake;Educational Status;Endocrinologist;enhancing factor;Environment;enzyme pathway;Enzymes;Epidemic;Ethnic Origin;Ethnic Population;Etiology;Event;Fasting;Food production;Funding;Genes;Genetic;genetic variant;Genetic Variation;genome wide association study;Genomic approach;Gluconeogenesis;Glucose;Glycolysis;Goals;Heart Diseases;Heart failure;Hispanic Community Health Study/Study of Latinos;Hospitalization;Hyperglycemia;Incidence;Infusion procedures;Ingestion;inorganic phosphate;Intake;Link;macrovascular disease;Medicine;Mendelian randomization;Mentors;Meta-Analysis;Metabolic Pathway;Metabolism;metabolomics;Microvascular Dysfunction;mortality;multi-ethnic;multiple omics;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Observational Study;Oral;Outcome;pandemic disease;Pathway interactions;Pentosephosphate Pathway;personalized approach;Persons;Physicians;Plasma;Population Heterogeneity;Prevalence;Prevention approach;Primary Prevention;Production;professor;Proteomics;Research;Research Proposals;Research Training;response;Risk;Risk Assessment;Risk Factors;Role;Safety;Sampling;Sampling Studies;Scientist;Serum;skills;stable isotope;tenure track;Testing;Tracer;Training;Transketolase;United States National Institutes of Health;Vascular Diseases;Visit

PROJECT_TITLE: Mechanisms and consequences of erythritol and erythronate excess in cardiometabolic disease

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: LEXINGTON

ORG_NAME: NAPROGENIX, INC

ORG_STATE: KY

PHR: Project Narrative Dependence on alcohol is a very serious problem in the US with a huge medical and financial burden. Current treatments are unsatisfactory and new medications are required. The applicants have synthesized a novel drug that has shown great promise in preclinical development, and this proposal is to obtain the data necessary before investigation of the drug in the human.

PI_NAMEs: BURKLOW, CINDY ANN (contact)

PROGRAM_OFFICER_NAME: SENEVIRATNE, CHAMINDI

PROJECT_TERMS: Administrative Supplement;alcohol abuse therapy;Alcohol dependence;alcohol use disorder;Alcohols;Authorization documentation;Canis familiaris;capsule;Clinical;Clinical Trials;cost;Cyclic GMP;Data;Dependence;Development;Dose;Drug Kinetics;Evaluation;Feedback;Financial Hardship;Formulation;Funding;Goals;Guanidines;Hour;Human;Investigation;Laboratories;manufacture;Medical;Methods;Modification;National Institute on Alcohol Abuse and Alcoholism;neurotoxicity;novel therapeutics;Oral;Parents;Pharmaceutical Preparations;Phase;phase 1 study;pre-Investigational New Drug meeting;preclinical development;Rattus;Recommendation;research clinical testing;response;Safety;safety study;Series;Toxicology;U-Series Cooperative Agreements;validation studies

PROJECT_TITLE: Development of JR-220 (4-Chlorobenzylidenamino-guanidine hydrochloride) as a medication for alcohol dependence


NIH_SPENDING_CATS: Autism;Bioengineering;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences

PHR: Narrative Neuropsychiatric disorders (NPDs), including autism spectrum disorder, epilepsy, and schizophrenia, are collectively common conditions in the human population that have a significant genetic component that remains mostly unexplained. Genetic studies to date have focused on the contribution of variant classes in isolation, and therefore hampers our understanding of overall architecture. This study will combine cutting- edge genetic variation detection algorithms, novel statistical methods, and large cross-disorder NPD datasets to jointly evaluate the contribution of the full range of human variation, from common to rare, coding to noncoding, and single-nucleotide to large structural, on NPD risk.

PI_NAMEs: FU, JACK MINYANG (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Advisory Committees;aggregation database;Algorithms;Architecture;autism spectrum disorder;Awareness;Biology;Biometry;career;case control;Categories;Code;cohort;Communication;comorbidity;Complex;Copy Number Polymorphism;Data;Data Set;Databases;Detection;Development;Developmental Delay Disorders;Diagnostic;Disease;disorder risk;Doctor of Philosophy;Environment;Epilepsy;Evaluation;exome;exome sequencing;experience;Family;family burden;Future;gene discovery;General Hospitals;Genes;Genetic;genetic architecture;genetic association;Genetic Diseases;Genetic Predisposition to Disease;Genetic study;genetic variant;Genetic Variation;Genome;Genomic medicine;Genomics;Goals;Grant;Heritability;Human;Human Genetics;improved;Individual;innovation;insertion/deletion mutation;insight;interest;Joints;Jordan;Learning;Massachusetts;Mentors;Mentorship;Methods;Modeling;Nature;Neurodevelopmental Disorder;Neurologic;Neurology;neuropsychiatric disorder;neuropsychiatry;novel;Nucleotides;Phenotype;Population;post-doctoral training;programs;rare variant;Research;Resolution;responsible research conduct;Risk;risk variant;Role;Sample Size;Schizophrenia;Single Nucleotide Polymorphism;skill acquisition;skills;Slice;Statistical Data Interpretation;Statistical Methods;statistics;Structure;success;Technology;Therapeutic;Time;Training;undergraduate student;Universities;Untranslated RNA;Variant;Work;Writing

PROJECT_TITLE: Integration of common, rare, and structural variation to define the genetic architecture of neuropsychiatric disorders

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Epilepsy;Health Services;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Telehealth

ORG_CITY: Berkeley

ORG_NAME: EYSZ, INC.

PHR: Narrative Childhood absence epilepsy (CAE) is the most common pediatric epilepsy syndrome, affecting 10–17% of all children with epilepsy. Those with CAE often experience significant diagnostic delay and limited monitoring due to the difficulty in detecting absence seizures, which also limits clinical studies of new anti-epileptic drugs in this patient population. An in-clinic diagnostic method would reduce the wait times associated with in-clinic VEEG appointments, potentially reducing time-to-diagnosis and improving access, especially in rural and low-income areas.

PI_NAMEs: KUPERMAN, RACHEL  (contact)

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Absence Epilepsy;Acceleration;Accelerometer;Accidental Injury;Address;Adoption;Adult;Advocacy;Affect;Agreement;Algorithmic Analysis;Algorithms;animation;anti-epileptic agents;Anticonvulsants;Anxiety;Appointment;Area;Automatism;Award;Awareness;Bachelor's Degree;behavioral health;Biological Sciences;Biometry;Blinking;Brain;burden of illness;Businesses;California;Cardiovascular system;care costs;career;Caregivers;Cellular Phone;Certification;Charge;Child;Childhood;childhood epilepsy;Chronic;Clinic;Clinical;clinical care;Clinical Research;Clinical Trials;Code;Collaborations;college;commercialization;commercialization readiness;comorbidity;Convulsions;cost;COVID-19;Current Procedural Terminology Codes;Data;Data Reporting;Decision Making;Degree program;Detection;detection method;detector;Development;Devices;Diagnosis;Diagnostic;Diagnostic Procedure;diaries;digital health;Direct Costs;disability;Disease remission;Documentation;drug development;Ecosystem;Educational process of instructing;Effectiveness;effectiveness measure;efficacy evaluation;Electrical Engineering;Electroencephalography;Electromyography;Emergency department visit;Engineering;Enrollment;Ensure;epidemiology study;Epilepsy;Esthetics;Excision;Exhalation;experience;Eye Movements;Face;falls;Family member;Fee-for-Service Plans;Fees;Fellowship;Foundations;Freedom;Frequencies;Funding;Generalized Epilepsy;Glass;global health;Goals;Government;Grant;Growth;handheld mobile device;Health Personnel;Healthcare;Healthcare Market;Heart Rate;Home;Home environment;Hospital Costs;Hospitalization;Hospitals;Hour;Hyperventilation;Impairment;Improve Access;improved;improved outcome;Industry;Influentials;Injury;innovation;Innovation Corps;Inpatients;Institution;Institutional Review Boards;interest;Intervention;Interview;Investments;Laws;Leadership;Learning;Legal;Legal patent;Length;Limb structure;Long term disability;Low income;Manufacturer;Marketing;Measures;Medical;Medical Device;Medicine;meetings;member;Mental Depression;Mentors;Methods;mHealth;mobile computing;Mobile Health Application;Modeling;Monitor;Morbidity - disease rate;mortality;mortality risk;Motion;motion sensor;Motor;Motor Seizures;Movement;Muscle;Names;Neurologic Dysfunctions;Neurologist;Neurology;neurophysiology;novel therapeutics;optimal treatments;Outcome;Outpatients;Patient advocacy;patient advocacy group;patient population;Patient Self-Report;Patients;payment;Pediatric Hospitals;pediatrician;Performance;Periodicity;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Physician's Role;Physicians;Physics;Population;population based;Positioning Attribute;Predisposition;Price;primary care provider;Process;product development;programs;Prospective, cohort study;psychologic;Quality of life;Readiness;Reading;Recommendation;Regimen;remote diagnosis;remote monitoring;Reporting;Reproducibility;Research;Research Personnel;respiratory;Risk;risk mitigation;Role;Rural;Sales;satisfaction;Schedule;Science;Seizures;Sensitivity and Specificity;Services;signal processing;Signal Transduction;Sleep Deprivation;Small Business Innovation Research Grant;smartphone application;social stigma;sound;Source;spelling;standard of care;Standardization;Structure;success;Symptoms;Syndrome;System;Techniques;Technology;telehealth;Testing;therapeutic development;Thinness;Time;Titrations;Tonic - clonic seizures;tool;Training;Translating;Treatment Efficacy;Treatment outcome;Treatment Protocols;treatment response;Unconscious State;United States National Institutes of Health;Universities;usability;Validation;Vision;visual tracking;volunteer;Wait Time;Washington;wearable device;Work;years of life lost;years of life lost to disability;young adult

PROJECT_TITLE: A Mobile Health Application to Detect Absence Seizures using Hyperventilation and Eye-Movement Recordings


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Hypertension is a leading risk factor for cardiovascular disease, with disproportionate burden in non-Hispanic Black individuals that is in part due to implicit bias in clinical care (unconscious stereotypes that affect clinician attitudes and behavior towards Black individuals). The proposed research will refine and standardize a racial implicit bias mitigation intervention and pilot test it in primary care, providing all necessary and sufficient information for a full-scale randomized clinical trial. The ultimate goal of this research is to promote racial equity in hypertension treatment and control.

PI_NAMEs: SVETKEY, LAURA P;WILSON, SARAH MOSHER (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Age;Attitude;Awareness;Behavior;Behavioral;black patient;Black Populations;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Caring;Cessation of life;Clinical;clinical care;clinical encounter;clinical practice;clinical research site;Clinical Services;Clinical Skills;Clinical Trials;Code;Collaborations;Data;Data Analyses;data management;design;Disparity;E-learning;Educational Curriculum;Educational process of instructing;electronic health data;Electronic Health Record;Enrollment;Ensure;Equity;evidence base;Exposure to;feasibility testing;Feedback;Goals;Grant;Health;health disparity;health equity;health equity promotion;Health Service Area;Health Services Accessibility;Health system;Healthcare;Heart failure;high risk;human centered design;Human Resources;Hypertension;hypertension control;hypertension treatment;implicit bias;Individual;Inequity;Intervention;Kidney Diseases;Knowledge;Learning;Logistics;Measures;Methods;Modeling;mortality;Not Hispanic or Latino;Outcome;participant enrollment;patient engagement;patient-clinician communication;Patients;Physicians;pilot test;Play;Population;practice-based research network;Prevalence;Primary Care;primary care clinic;primary care clinician;primary care practice;Procedures;Protocols documentation;Quality of Care;Race;racial disparity;Racial Equity;racial health disparity;randomized effectiveness trial;randomized trial;randomized, clinical trials;Research;Risk Factors;Role;Severities;skills;social health determinants;Standardization;Stereotyping;Stroke;Structural Racism;Surgeon;Technology;Testing;Training;Unconscious State;United States;virtual;virtual technology;Work

PROJECT_TITLE: Planning grant for clinical trial of implicit bias mitigation training for clinicians

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT (MA)]


ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE/PUBLIC HEALTH SIGNIFICANCE The proposed research is relevant to public health because it proposes applying human-centered design, an established approach that has been successfully applied to implementation problems in other domains of technology, to the challenge of incorporating patient/user perspectives in the design of novel neurotechnologies. Human-centered design in neurotechnology holds potential to address key neuroethical problems and also to enhance the usability and feasibility of new treatments based on BRAIN Initiative-supported research. Thus, the proposed research is relevant to the NIH’s mission of applying knowledge to enhance health and to reduce illness and disability.

PI_NAMEs: CHIONG, WINSTON  (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Achievement;Address;Adopted;Adoption;Anthropology;Articulation;Attitude;BRAIN initiative;Conceptions;Data;design;Development;Devices;Diamond;digital technology;disability;Disabling;Engineering;Ethics;experience;Failure;Familiarity;Focus Groups;Future;Goals;Health;Health system;Healthcare;Human;human centered design;Implant;implantable device;improved;innovation;insight;interdisciplinary approach;Intervention;Interview;Knowledge;Lived experience;Manufacturer;Measures;Methodology;Methods;Mission;motor disorder;nervous system disorder therapy;neural;neuroethics;neuropsychiatric disorder;Neurosciences;neurotechnology;novel;Outcome;Patients;Persons;Play;prevent;Process;prospective;Psychology;Public Health;Published Comment;Qualitative Methods;Research;Research Personnel;Research Support;Resources;retina implantation;Risk;Role;Sensory Disorders;Social Sciences;sound;success;System;Technology;technology platform;tool;Trust;United States National Institutes of Health;usability;Visually Impaired Persons;Work

PROJECT_TITLE: Neuroethics and human-centered design in neurotechnology

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-S (03)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Palliative Care

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: PROJECT NARRATIVE The development of novel neurotechnologies has not only expanded the range of treatment options available to patients, but also increased the complexity around ethical decision-making, in particular, when these interventions are considered earlier in the disease progression. This study will provide in-depth new knowledge regarding neuroethical issues around shared-decision making and decisional needs of patients and clinicians associated with the early use of neurotechnology, and address these issues by developing and testing a patient-centered decision aid (PtDA) for advanced neurotechnology. Responding to the BRAIN Initiative imperatives, our resulting PtDA will enhance shared decision-making and guide ethical choices surrounding the early use of neurotechnology.

PI_NAMEs: CABRERA TRUJILLO, LAURA YENISA (contact)

PROJECT_TERMS: Address;advanced disease;Attitude;Benefits and Risks;Brain;BRAIN initiative;brain surgery;Caregivers;Caring;Case Study;Clinical;Clinical Ethicists;clinical research site;Collaborations;Complex;Conflict (Psychology);Data;Decision Aid;Decision Making;Deep Brain Stimulation;design;Development;Disease;Disease Progression;Early treatment;efficacy evaluation;Ethical Issues;Ethics;experience;field study;Goals;Guidelines;Hospital Administration;improved;Informed Consent;instrument;International;Intervention;Interview;Knowledge;Literature;Mental disorders;Methods;Modeling;Motor;Movement Disorders;neuroethics;Neurologic;Neurologist;Neurosurgeon;neurotechnology;novel;Nurses;Parkinson Disease;patient navigation;patient oriented;Patients;preference;prototype;Provider;Regrets;Research;satisfaction;shared decision making;Social Workers;standard of care;Structure;Testing;Therapeutic;tool;Uncertainty;Work

PROJECT_TITLE: Improving Shared Decision Making in Early use of Neurotechnologies Across Different Disease Stages


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

PHR: Youth in the United States are at increased risk of poor mental health, sadness, hopelessness, and suicide ideation, and despite need, access to mental health care and prevention may be inadequate. Globally, task-shifting—training non-mental health providers to deliver mental health interventions in community settings—has shown promise in reducing depression symptoms and increasing access to care. However, its application as a suicide prevention strategy within the United States remains understudied. This proposal seeks to rigorously evaluate the feasibility and acceptability of an adapted evidence-based mental health intervention, delivered by trained mentors, to mitigate key risk factors for passive suicide ideation among youth in community centers. This upstream approach aims to prevent the onset of suicide behaviors, thereby addressing a critical public health need.

PI_NAMEs: VÉLEZ-GRAU, CAROLINA  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;Adult;Age;aged;Area;Boston;career development;Clinical;Clinical Investigator;Clinical Trials Design;Collaborations;Communities;community building;community center;community partners;community setting;contextual factors;Country;Depressed mood;depressive symptoms;Development Plans;disadvantaged background;disparity reduction;Effectiveness;Elements;empowerment;Equity;ethnic minority population;Ethnic Origin;evidence base;Evidence based intervention;feasibility testing;Feeling;Feeling hopeless;Feeling suicidal;gaps in access;Gender;Generations;Goals;health care disparity;health disparity;health equity;Health Personnel;Health Services;Health Services Accessibility;health training;high risk;Hispanic;implementation determinants;implementation science;implementation strategy;improved;Incidence;innovation;interpersonal therapy;Intervention;Language;Latina;Latino;Latinx;Learning;Manuals;Mental Depression;Mental Health;Mental Health Services;Mentors;mortality;National Institute of Mental Health;Play;Population;population based;post intervention;post-COVID-19;Pragmatic clinical trial;pragmatic randomized trial;prevent;Prevention program;Prevention strategy;Preventive;preventive intervention;primary care setting;Process;Protocols documentation;Provider;Public Health;randomized trial;Reporting;Research;Research Project Grants;Resources;Risk;Risk Factors;Schools;Self-Injurious Behavior;skills;Strategic Planning;structural determinants;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Support System;Testing;Training;Training Support;Trust;Uninsured;United States;willingness;Youth

PROJECT_TITLE: Task-Shifting: Brief Interpersonal Psychotherapy by Youth Mentors for Latinx Youth Suicide Prevention

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE PIEZOs are mechanosensitive ion channels that convert force into an electrical signal, and they play critical roles in diverse physiological processes including respiration, touch, proprioception, and vascular development. The goal of this proposal is to determine the fundamental structural mechanics underlying PIEZO ion channel function. This research will advance our understanding of the molecular mechanisms of PIEZO ion channel activation and provide insights into how channel dysfunction causes disease.

PI_NAMEs: MULHALL, ERIC MICHAEL (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Actins;Address;Architecture;Arthrogryposis;Binding;Biophysical Process;Blood Vessels;Breathing;Cations;Cell membrane;Cells;Cysteine;Cytochalasin D;Cytoskeleton;Defect;Development;Disease;Distal;disulfide bond;E-Cadherin;Elasticity;Electrophysiology (science);Environment;Etiology;experimental study;flexibility;Fluorescence;fluorescence imaging;Foundations;Functional disorder;gain of function;gain of function mutation;Genetic Diseases;Goals;imaging approach;In Vitro;insight;Ion Channel;Ions;jasplakinolide;Kinetics;knock-down;Knowledge;Laboratories;Lipids;Mammals;Measures;mechanical force;mechanical properties;Mechanics;Mediating;Membrane;Modality;Molecular;Molecular Conformation;Movement;Mutagenesis;mutant;Mutation;nano;nanometer resolution;nanoscale;Nanoscopy;Nature;Nervous System Disorder;Osmosis;Output;Pathogenicity;Physiological;Physiological Processes;Piezo 1 ion channel;Piezo 2 ion channel;Piezo ion channels;Play;Property;Proprioception;Proprioceptor;Proteins;Research;Resolution;Respiration;Rest;Role;scaffold;sensor;Sensory;Sensory Process;Shapes;Signal Transduction;single molecule;Site;Stimulus;Structural Models;Structure;System;Touch sensation;Transducers;Transmembrane Domain;Work

PROJECT_TITLE: The Molecular Basis of PIEZO Ion Channel Function


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PHR: PROJECT NARRATIVE  HIV evolves to escape the human immune system and drug therapies, but it is constrained by the need to interface with host cell components that allow for infection. This proposal will take an innovative high- throughput approach to comprehensively parse the functional and innate immune-imposed evolutionary constraints on the HIV capsid protein, a critical immune and therapeutic target. These results will reveal how HIV structurally interfaces with and escapes from human innate immunity, and they will allow us to identify viral Achille's heels that can be synergistically constrained by native human immunity and capsid-targeting drugs to limit viral escape, which is a major barrier to effective antiviral therapy.

PI_NAMEs: TENTHOREY, JEANNETTE  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Affect;Anti-viral Therapy;Basic Science;Binding;Biochemical;Biochemistry;Biology;Capsid;Capsid Proteins;Cells;Cellular Structures;Complex;Data;design;Drug Design;Drug Targeting;effective therapy;Evolution;experimental study;fitness;Focus Groups;Genomics;global health;Goals;Heel;HIV;HIV Infections;HIV therapy;HIV-1;Human;Immune;Immune system;Immune Targeting;Immunity;Immunotherapeutic agent;In Vitro;Individual;Infection;Innate Immune Response;innovation;insight;Integration Host Factors;Knowledge;lens;Libraries;Life Cycle Stages;Location;Maps;Masks;Measurement;Measures;Methods;Missense Mutation;Modeling;Molecular;Mutagenesis;Mutation;Natural Immunity;new therapeutic target;novel therapeutics;pathogenic virus;Pharmaceutical Preparations;Pharmacotherapy;Positioning Attribute;post-doctoral training;pressure;prevent;Production;Proteins;Resolution;Resources;Sampling;Site;Source;success;Surface;targeted treatment;Technology;Therapeutic;therapeutic target;tool;TRIM5 gene;usability;Viral;Viral Proteins;virology;Virus;Vulnerable Populations;Work

PROJECT_TITLE: Defining HIV evolution at the innate immune interface


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Climate-Related Exposures and Conditions;Foodborne Illness;Lung

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Harmful algal blooms (HABs) are most commonly known to make animals and people sick through contaminated food and water. We now know that HABs can also can become aerosolized and inhaled but the associated health effects are not well understood. Defining a role for HAB aerosols in the protection of human health by advancing our understanding of inhalation exposures and novel health outcomes is critical to inform management programs and health risk.

PI_NAMEs: SABO-ATTWOOD, TARA L (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Acute;Address;aerosolized;Aerosols;Affect;aged;Aging;Air;Algae;Algal Blooms;animal data;Animals;aquatic organism;Atmosphere;Biological;Cell Culture Techniques;Cell model;cell type;Cells;chemical reaction;Chemicals;Climate;coastal water;Collaborations;Communication;Complex;Coughing;Cyanobacterium;cyanoginosin LR;cylindrospermopsin;Cylindrospermopsis;Data;Dendritic Cells;Development;economic cost;Ecosystem;Environment;Epithelial Cells;Epithelium;Event;exposure route;Exposure to;extracellular;extracellular vesicles;Fishes;Food Contamination;Fresh Water;Gene Expression Profile;Genes;Goals;harmful algal blooms;Health;Hepatotoxicity;Human;Immune;Immune response;in vivo;Ingestion;Inhalation;Inhalation Exposure;innovation;Investigation;Kidney;Knowledge;Link;Liquid substance;Literature;Liver;Lung;lung health;marine;Medicine;Microbiology;Microcystis;MicroRNAs;mortality;nephrotoxicity;Nose;novel;Outcome;Oxidants;oxidation;Persons;photolysis;Pollution;Population;Process;Production;programs;red tide;Reporting;Research;Research Personnel;Respiratory Signs and Symptoms;response;Risk;Role;Science;Sea;Series;severe weather;Signal Transduction;social;Source;Sunlight;Supporting Cell;System;Temperature;Testing;Time;Toxic effect;Toxicology;Toxin;Transcription Initiation;transcriptome;Translating;United States;Variant;Water;water testing;Work

PROJECT_TITLE: Atmospheric transformation of harmful cyanobacterial algae and novel mechanisms of pulmonary toxicity

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Pediatric;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE A growing concern among researchers and clinicians is of frequent and high-intensity cannabis use (e.g., daily/near daily use, use multiple times a day, and use of higher potency THC products). Mobile health (mHealth) technology may help address gaps between clinical need and formal clinical services, particularly for non-collegiate young adults. The proposed R34 application uses a multi-method user-informed approach to develop a novel brief motivational mHealth intervention that incorporates cutting-edge cannabis intervention research and emphasizes YAs’ autonomy.

PI_NAMEs: LEE, CHRISTINE M. (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Age;Area;attentional control;Behavioral;brief intervention;brief motivational intervention;Cannabis;Cellular Phone;Clinical;Clinical Services;Cognitive;cognitive function;college;Coping Skills;design;Development;District of Columbia;Drug usage;Education;Effectiveness of Interventions;Emotions;Ensure;Evaluation;experience;Feedback;Focus Groups;Frequencies;Future;Goals;Guidelines;Health Technology;high risk;innovation;interest;Intervention;Intervention Studies;Interview;Language;Legal;Life;marijuana use;marijuana use disorder;Measures;Methods;mHealth;mhealth interventions;Military Personnel;Motivation;motivational enhancement therapy;National Institute of Drug Abuse;negative mood;novel;Occupational;Online Systems;Pattern;peer;Personal Satisfaction;personalized intervention;Pilot Projects;post intervention;Prevalence;Process;Program Acceptability;programs;psychoeducation;Publishing;Randomized;Readiness;Recreation;Reporting;Research;Research Personnel;Risk;Schools;Self Determination;Self Efficacy;Services;skills;skills training;social;social skills;Strategic Planning;success;tailored text messaging;Technology;Text Messaging;theories;therapy development;time use;trend;underserved community;Unemployment;usability;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Feasibility/Acceptability of a Brief Motivational Intervention Integrating Online Personalized Feedback & Tailored Text Messages for Frequent/High-Intensity Cannabis Use in Post-Legalization Landscape

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

PHR: NARRATIVE. Novel vaccination strategies are necessary to contain TB, as the currently licensed anti-TB vaccine, Bacille Calmette-Guerin (BCG), has limited efficacy. We have developed a strain of Mycobacterium tuberculosis which effectively protects against TB prior to granuloma formation with strong early responses. We will study how these very early immune responses generate protection from TB before granulomas are formed.

PI_NAMEs: KAUSHAL, DEEPAK  (contact);KHADER, SHABAANA A.

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Ablation;adaptive immunity;Address;Adverse event;Aerosols;Alleles;Animals;Antibody Repertoire;Antigens;Attenuated;B-Lymphocytes;BCG Live;biological adaptation to stress;Biology;Bronchi;Bronchus-Associated Lymphoid Tissue;CD8-Positive T-Lymphocytes;Cells;cellular imaging;clinical development;co-infection;Complement;Data;Development;Disease;Dose;Environment;Event;experimental study;Exposure to;Generations;Genetic Transcription;Granuloma;HIV;HIV/TB;Human;Immune;Immune response;Immunity;immunological status;Infection;Innate Immune Response;Interferons;Intervention;Intravenous;Knowledge;lead candidate;Lesion;Licensing;Lung;lymphoid structures;Macaca fascicularis;Macaca mulatta;Maps;Mediating;Modeling;MS4A1 gene;Mucous Membrane;mutant;Mycobacterium tuberculosis;Natural Immunity;novel;pandemic disease;pathogen;Peripheral;PET/CT scan;pre-clinical;preclinical development;prevent;recruit;Resistance;Resolution;Respiratory Burst;response;Role;Serology;Signal Transduction;single-cell RNA sequencing;Stimulus;Stress;System;T cell response;T-Lymphocyte;Techniques;Technology;Testing;transcription factor;Tuberculosis;Tuberculosis Vaccines;Vaccinated;Vaccination;vaccination against tuberculosis;vaccination strategy;vaccine candidate;vaccine platform;Vaccines;Work

PROJECT_TITLE: Mechanisms of efficient control of Mycobacterium tuberculosis in the lungs prior to granuloma

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 RCU-A (M1)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Sepsis

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Vancomycin-resistant Enterococcus faecium has become a concerning opportunistic pathogen known to cause recurrent infections in high-risk patients, and few antibiotics are available to treat this organism. We have limited knowledge regarding the bacterial genomic and phenotypic adaptations that arise within the human host during infection that lead to persistent and recurrent disease. This proposal outlines a training program designed to equip Dr. Stellfox with the essential skills in comparative genomics, evolutionary biology, phage biology, and pharmacology that are necessary to discover new bacterial cellular pathways associated with recurrent enterococcal bacteremia and evaluate the potential of bacteriophage-antibiotic combinations to combat challenging enterococcal infections.

PI_NAMEs: STELLFOX, MADISON ELAINE (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;Antibiotic Therapy;antibiotic tolerance;Antibiotics;antimicrobial;aspirate;Bacteremia;bactericide;Bacteriophages;Biology;Blood Circulation;career development;Case Study;Clinical;clinical practice;clinically relevant;cohort;Collection;combat;Combined Antibiotics;Communicable Diseases;Comparative Genomic Analysis;comparative genomics;Complex;Daptomycin;Data;Dedications;design;Disease;Doctor of Philosophy;Dose;Drug Kinetics;educational atmosphere;Enterococcus;Enterococcus faecium;Evolution;experience;experimental study;Future;gastrointestinal;Genetic;Genetic Markers;genetic signature;genome wide association study;Genomic approach;genomic signature;Genomics;Genotype;Gram-Positive Bacteria;Growth;high risk;Human;human microbiota;Immunocompromised Host;improved;In Vitro;in vivo;indexing;Infection;insight;Instruction;Kinetics;Knowledge;Laboratories;Linezolid;Mainstreaming;Medical center;member;Mentors;Mentorship;microbial genome;Modeling;novel;opportunistic pathogen;Organism;oritavancin;Outcome;pathogen;Pathway interactions;Patients;pharmacokinetic model;Pharmacology;Phenotype;Physicians;Postdoctoral Fellow;practical application;pre-clinical;preclinical study;predictive marker;Prevalence;prevent;Program Development;programs;prospective;Recurrence;Recurrent disease;recurrent infection;Regimen;Relapse;Research;Research Personnel;Research Training;Resistance;Resources;Role;Sampling;Scientist;Sepsis;Serum;skills;synergism;Techniques;Testing;Therapeutic;Time;tool;Training;Training Programs;Treatment Protocols;Universities;Vancomycin Resistance;Vancomycin resistant enterococcus;Vulnerable Populations

PROJECT_TITLE: Genetic and phenotypic adaptations of vancomycin-resistant Enterococcus faecium during recurrent bloodstream infection

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]