ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Advances in human genomics are transforming the diagnosis, treatment, and prevention of disease. However, there are too few clinical geneticists and counselors to meet rising demand and non-geneticist clinicians feel under-prepared to incorporate genetics into their medical practice, highlighting the need to produce more genomically-literate clinicians. To help meet this need, we plan to develop an innovative one-year Master of Science (MS) program in Genomic Medicine for UCSF medical students.

PI_NAMEs: HYLAND, KATHERINE ;RISCH, NEIL J. (contact)

PROGRAM_OFFICER_NAME: COLLEY, HEATHER

PROJECT_TERMS: Active Learning;African American;Budgets;California;cancer genomics;Cardiovascular Diseases;Clinical;clinical application;Clinical Clerkship;clinical practice;clinical translation;Cognitive;Collaborations;Communication;Communities;Competence;Course Content;curriculum development;Degree program;Diagnosis;disorder prevention;diversity and inclusion;Education;education resources;educational atmosphere;Educational Curriculum;Educational Materials;Educational process of instructing;Effectiveness;Enrollment;Environment;equity, diversity, and inclusion;Ethical Issues;ethical, legal, and social implication;experience;Faculty;Feedback;Funding;Future;Genetic;genetic counselor;genetic information;genetic risk assessment;genetic testing;Genomic medicine;Genomics;Goals;Grant;Health Personnel;Human Genetics;human genomics;improved;Informatics;Informed Consent;innovation;interest;Laboratories;learning materials;literate;Literature;Master of Science;matriculation;Medical;Medical Education;Medical Genetics;medical schools;medical specialties;Medical Students;Medicine;meetings;member;Mental disorders;Modality;Molecular Genetics;Needs Assessment;neurogenetics;novel;Nursing Faculty;outreach;Patients;Persons;Physicians;Policies;Population;Preventive care;Principal Investigator;Process;Professional counselor;Program Development;programs;Provider;Publishing;recruit;reproductive;Research;Research Methodology;Research Personnel;Rotation;Science;simulation;Structure;Student recruitment;Students;success;Surveys;symposium;System;Technology;Testing;Time;tool;Training;Training Activity;trend;United States National Institutes of Health;Universities;Variant;web site

PROJECT_TITLE: Genomic Medicine Master's Degree Program for Medical Students

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (O1)]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Pediatric

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Narrative Research advances in the field of Pediatric Cardiology have led to both improved clinical outcomes and major scientific insights. Research training through this NHLBI program will continue to build on this success by constantly incorporating new discoveries into the individual training curricula of our mentees. Our NHLBI training program, now in its 24th year, has demonstrated that our trainees contribute strongly to advances in the field, while establishing their own independent, productive careers.

PI_NAMEs: LEVY, ROBERT J (contact);ROSSANO, JOSEPH W

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TITLE: Training in Molecular Therapeutics for Pediatric Cardiology

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM (OA)]


ADMINISTERING_IC: HD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative This project will develop an integrated set of data enhancements and user education tools and activities to ex- pand researchers’ use of data from the Panel Study of Income Dynamics (PSID), the PSID Child Development Supplement (CDS), and the PSID Transition into Adulthood Supplement (TAS).

PI_NAMEs: INSOLERA, NOURA ELISE (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Acceleration;aged;Behavior;Charge;Child;child bearing;Child Development;cohort;college;Communities;Complex;Consumption;Contracts;Data;Data Analyses;data archive;data centers;Data Collection;Data Set;design;Development;Documentation;Economics;Education;Educational process of instructing;Educational workshop;Enrollment;Ensure;Exercise;experience;Family;Family dynamics;Feedback;follow-up;Fostering;Funding;Generations;Goals;graduate student;Health;Health behavior;health disparity;Health Status;Household;Income;innovation;interest;intergenerational;Investments;lectures;Life;Life Cycle Stages;Link;Location;Longitudinal Surveys;Marriage;Measurement;meetings;member;migration;National Institute of Child Health and Human Development;Neighborhoods;Obesity;online version;Outcome;outreach;panel study of income dynamics;Personal Satisfaction;Policies;Postdoctoral Fellow;Poverty;Process;Productivity;Professional Organizations;professor;Research;Research Personnel;Research Support;Resources;response;Sampling;Savings;Schools;Series;Services;Slide;Smoking;social;Social Sciences;Socioeconomic Status;Surveys;symposium;Teenagers;Time;time use;tool;Training;transition to adulthood;transmission process;Video Recording;Wages;web site;webinar;young adult

PROJECT_TITLE: PSID, CDS, and TA: Data Enhancements and User Training, Support, and Outreach

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: NEUROSURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: Our active, engaged commitment to increasing the diversity of Neurosurgery and Neurology (NSci) residents well prepared for independent research careers, directly benefits the trainees, patients, and scientific communities we serve. We will focus on early engagement in research training, individualized and enduring mentorship of the R25 scholars, and iterative program design to foster the strongest, most diverse pool of NSci physician scientists.

PI_NAMEs: HAYDEN GEPHART, MELANIE  (contact);PORTER, BRENDA ELAINE

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Accountability;Address;Advisory Committees;Architecture;Award;career;Cementation;clinical training;cohort;Collaborations;Communities;community college;Community Networks;Complex;design;Dimensions;diversity and equity;diversity and inclusion;Education;Education Projects;education research;Enrollment;Ensure;Environment;Equity;equity, diversity, and inclusion;experience;Feedback;Fostering;Goals;Grant;implicit bias;improved;Individual;Inequity;innovation;Institution;Leadership;marginalized community;medical schools;Medical Students;Medicine;Mentored Clinical Scientist Development Program;Mentors;Mentorship;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurologic;Neurology;Neurosciences;neurosurgery;outreach;outreach program;Participant;Pathway interactions;Patients;Physicians;Preparation;prevent;Productivity;programs;recruit;Reproducibility;Research;Research Ethics;Research Training;Residencies;Resource Allocation;role model;Science;Scientific Advances and Accomplishments;Scientist;skills;social exclusion;Structure;Students;success;Time;timeline;Training;Training Programs;translational impact;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;virtual;Vision;Visit;Woman;Work;Writing

PROJECT_TITLE: Stanford Neurosurgery and Neurology Resident Research Education Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-B (03)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative The goal of this training grant is to provide students who 1) are well trained in the study of mechanisms of viral replication, 2) can investigate human viruses causing disease, such as the human immunodeficiency virus and herpes viruses, 3) can investigate new antiviral compounds and vaccines to prevent or treat viral diseases, 4) can study viruses that are emerging threats to human health, and 5) can use viruses to probe the cellular and molecular biology of prokaryotic and eukaryotic cells.

PI_NAMEs: KNIPE, DAVID M. (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Molecular;Viral

PROJECT_TITLE: Molecular Basis of Viral Infectivity

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: DALLAS

ORG_DEPT: NEUROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE The development of clinician-scientists in the neurosciences is critical for future advances in the care of patients with neurological disorders. The UT Southwestern Advancement of Neuroscience Research Careers (UT SWANS) research training program provides the infrastructure, support, training, and mentorship for neurologists and neurosurgeons in clinical training to excel in neuroscience research as future independent physician scientists.

PI_NAMEs: LOUIS, ELAN D (contact);POURATIAN, NADER

PROJECT_TERMS: academic preparation;Academic Training;Acceleration;Appointment;Automobile Driving;Brain;career;career development;Clinical;clinical training;clinically relevant;Collection;Communication;Communities;Data;Dedications;Development;Discipline;Ensure;Environment;Equilibrium;experience;Faculty;faculty mentor;Fostering;Foundations;Funding;Future;Generations;Goals;Grant;Infrastructure;innovation;Institution;Investments;K-Series Research Career Programs;Leadership;Mentors;Mentorship;mid-career faculty;multidisciplinary;Nervous System Disorder;Neurologist;Neurology;Neurosciences;Neurosciences Research;Neurosurgeon;neurosurgery;Neurosurgical Procedures;Patient Care;Physicians;Positioning Attribute;prevent;Process;Productivity;programs;Records;recruit;Research;research and development;Research Methodology;Research Training;Residencies;Resources;responsible research conduct;Rewards;Role;role model;Scientist;skills;Structure;success;symposium;synergism;Talents;Trainers Training;Training;Training Activity;training opportunity;Training Programs;Uncertainty;United States National Institutes of Health;Visit;Writing

PROJECT_TITLE: UT Southwestern Advancement of Neuroscience Research Careers (UTSWANS)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Chronic Pain;Drug Abuse (NIDA only);Pain Research;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Our proposed training program, “BUilding an InterprofessionaL and Diverse workforce in substance Use and Pain” (BUILD-UP), will train the next generation of researchers at the intersection of substance use and chronic pain, a cutting-edge field with few current training options. BUILD-UP will prioritize recruitment of postdoctoral fellows from diverse groups including individuals who identify as being from a group excluded based on ethnicity and race, being from a disadvantaged background, having a disability, or being LGBT+, and will reduce barriers and promote equity in participation by allowing fully remote training. Therefore, BUILD- UP will have the important public health impact of both expanding and diversifying the workforce in this critical area.

PI_NAMEs: MERLIN, JESSICA S (contact);WINSTANLEY, ERIN L

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Diverse Workforce;Pain;substance use

PROJECT_TITLE: Building an interprofessional and diverse workforce in substance use and pain

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Anesthesiologists are medical specialists that lead care teams managing a wide range of patients undergoing procedures, in critical care units, and suffering from pain. This project will train selected anesthesiologists to perform scientific research, so that they may become future leaders whose research efforts will improve the practice of anesthesiology, resulting in better patient care.

PI_NAMEs: FORMAN, STUART A (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Research Training

PROJECT_TITLE: Research Training for Anesthetists

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-A (PD)]


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: The goal of this research training program is to train outstanding academic physician-scientists in Neurological Surgery and Neurology. The program combines longitudinal interdisciplinary neuroscience instruction with strong faculty mentorship throughout their residency, and a structured resident research experience. Participants will complete the program with the necessary skills and experience to design and perform high- quality collaborative neuroscience research, acquire independent funding, and attain academic faculty physician-scientists appointments.

PI_NAMEs: LEVITT, MICHAEL ROBERT (contact);WEINSTEIN, JONATHAN R

PROJECT_TERMS: Acute;Appointment;Authorship;career;Communities;Conflict of Interest;Dedications;design;Development;Education Projects;Educational Curriculum;Ensure;Environment;Ethics;experience;Experimental Designs;Faculty;faculty mentor;Fellowship;Funding;Future;Goals;Instruction;interest;K-Series Research Career Programs;knowledge base;Leadership;Medicine;Mentors;Mentorship;multidisciplinary;Nerve Degeneration;nerve injury;neuro-oncology;Neurodegenerative Disorders;neurogenetics;Neurology;neurorestoration;Neurosciences;Neurosciences Research;neurosurgery;Neurosurgical Procedures;new technology;next generation;Participant;Physicians;Preparation;Process;programs;recruit;Research;Research Ethics;Research Infrastructure;Research Personnel;Research Training;Residencies;Resources;responsible research conduct;Scientist;skills;statistics;Structure;success;Supervision;symposium;Training;Training Programs;United States National Institutes of Health;Universities;Vocational Guidance;Washington

PROJECT_TITLE: Neurological Surgery and Neurology research training in interdisciplinary neuroscience


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE The Vanderbilt University Cardiovascular Medicine T32 (VUCM-T32) aims to train the next generation of cardiovascular scientists and mentors with expertise in adult heart and vascular disease. Post-doctoral trainees will make discoveries during and after their training that will improve our understanding of heart and vascular disease and lead to new treatments, approaches to screening, and mechanisms.

PI_NAMEs: FREEDMAN, JANE E (contact);SHAH, RAVI

PROJECT_TITLE: Vanderbilt University Cardiovascular Medicine Training Program


NIH_SPENDING_CATS: Hematology

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Research in hemostasis, thrombosis, and vascular biology addresses fundamental mechanisms underlying bleeding, thrombotic disorders, and diseases of the blood vessels. Taken together, these pathologies account for more than half of all morbidity and mortality among U.S. citizens. This Program in Blood Coagulation and Vascular Biology will train the next generation of scientists to study problems related to hemostasis, thrombosis, and vascular biology.

PI_NAMEs: FLAUMENHAFT, ROBERT C (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: NARRATIVE – OVERALL Stem cells, which are present in most tissues, are responsible for maintaining tissue structure and function during normal activity and for repairing tissues in response to injury. One of the hallmarks of aging is the decline in the ability of tissues to perform these functions due at least in part to the decline in stem cell function with age. The studies of this proposal are designed to examine why stem cell function declines with age and how to restore youthful function to aged stem cells.

PI_NAMEs: RANDO, THOMAS A. (contact)

PROGRAM_OFFICER_NAME: COGLIATI, TIZIANA PAOLA

PROJECT_TERMS: adult stem cell;Age;age related;age related changes;age related decline;aged;Aging;aging clocks;aging process;Area;Bioinformatics;Biological Assay;Biology of Aging;Blood;Brain;Cells;Chromatin;Chronology;Creativeness;CRISPR/Cas technology;Cytometry;Data;data sharing;design;dietary;dietary restriction;Elderly;Epigenetic Process;epigenomics;Exercise;Flow Cytometry;Foundations;Functional disorder;Genetic;Genetic Determinism;Genetic Screening;Genetic Transcription;genome sequencing;Goals;Grant;hallmarks of aging;Health;healthspan;Hematopoiesis;Hematopoietic stem cells;Heterogeneity;Homeostasis;Human;improved;Individual;innovation;International;Intervention;Intervention Studies;Laboratories;Laboratory Study;Leadership;Mediating;Mediator;Metabolic;metabolomics;Molecular;Molecular Analysis;Muscle;muscle progenitor cell;Mutation;nerve stem cell;Parabiosis;Pharmaceutical Preparations;Plasma;Population;Program Research Project Grants;programs;Property;Proteomics;Records;regenerative;Regenerative capacity;Regulation;Rejuvenation;repaired;Research Personnel;response to injury;Role;single-cell RNA sequencing;stem cell aging;stem cell biology;stem cell function;stem cell population;stem cells;Structure;success;Technology;Therapeutic;Time;tissue repair;Tissues;transcriptomics;Visualization;Work

PROJECT_TITLE: Molecular Regulation of Stem Cell Aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-P (O3)]


NIH_SPENDING_CATS: Aging


NIH_SPENDING_CATS: Aging;Biotechnology

PI_NAMEs: BENDALL, SEAN CURTIS (contact)

PROJECT_TERMS: Age;age related changes;Aging;aging related;Antibodies;Atlases;Bioinformatics;Biological Assay;Bone Marrow;Brain;Cell Cycle;Cells;Cellular Assay;Central Nervous System;Chromatin;chromatin modification;Computing Methodologies;Cytometry;Data;Data Collection;density;Elements;Ensure;Epigenetic Process;Event;experience;experimental study;Functional disorder;Funding;Grant;Graph;Hematopoietic;Hematopoietic stem cells;Image;Immune;Inflammatory;innovative technologies;invention;Isotopes;Link;Maps;Metabolic;Metabolism;Molecular;Multiplexed Ion Beam Imaging;Mus;Muscle;muscle progenitor cell;Myelogenous;nanoscale;Neighborhoods;nerve stem cell;next generation;novel;Organizational Change;Phenotype;Play;programs;Property;Proteomics;Regulation;Rejuvenation;Reporter;Research Project Grants;Role;Signal Transduction;single cell analysis;stem cell aging;stem cell population;stem cells;Suspensions;System;Techniques;Technology;Tissue atlas;Tissue imaging;tissue/cell preparation;Tissues;tool;Trees;Work


NIH_SPENDING_CATS: Aging;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: PELLEGRINI, MATTEO  (contact)

PROJECT_TERMS: Age;age related;age related changes;Aging;aging clocks;ATAC-seq;Bioinformatics;Biology;bisulfite;bisulfite sequencing;cell age;cell type;Cells;ChIP-seq;Chromatin;Complex;Custom;Cytosine;Data;Data Analyses;data analysis pipeline;Data Display;data hub;data integration;data quality;Data Set;data standards;data visualization;Databases;Dedications;Development;DNA Methylation;Ensure;epigenetic clock;Epigenetic Process;epigenome;epigenomics;experience;Familiarity;file format;Genetic Transcription;Genomic approach;genomic data;Genomics;histone modification;Individual;life span;machine learning method;Measurement;Measures;member;Methodology;Methods;Methylation;Modeling;Molecular;Molecular Profiling;next generation sequence data;next generation sequencing;Non-linear Models;Pacemakers;Process;programs;Regulation;Research;Research Personnel;Sampling;Scientist;Sequence Alignment;Services;single cell genomics;single-cell RNA sequencing;stem cell aging;stem cells;Techniques;Technology;Tissues;tool;transcriptome;transcriptome sequencing;transcriptomics;Visualization;web site


NIH_SPENDING_CATS: Aging;Genetics;Human Genome;Nutrition;Regenerative Medicine;Sarcopenia;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PROJECT_TERMS: Age;age effect;age related;age related changes;age related decline;aged;Aging;aging population;Architecture;Area;ATAC-seq;Attention;Bioinformatics;bioinformatics resource;Cell Count;Cell Physiology;Cells;Characteristics;ChIP-seq;Chromatin;cofactor;Collaborations;Cytometry;Data;Diet;diet and exercise;Dietary Intervention;Epigenetic Process;epigenome;epigenomics;Exercise;Fasting;Foundations;Genetic;Genetic Transcription;genome-wide;Glutathione;Goals;Grant;Heterochromatin;Heterogeneity;histone methylation;histone methyltransferase;Homeostasis;In Situ;Intervention;intervention effect;Laboratories;Lysine;Maintenance;Maps;Mediating;Mediator;Metabolic;Metabolism;metabolomics;Modality;Molecular;Multiplexed Ion Beam Imaging;Muscle;muscle aging;muscle progenitor cell;Older Population;Parabiosis;Pathway interactions;pharmacologic;Polyamine Synthesis Inhibition;Polyamines;programs;Property;Proteomics;Reaction;Regenerative capacity;Regulation;Rejuvenation;repaired;Reporting;response;response to injury;restoration;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Skeletal Muscle;stem cell aging;stem cell niche;stem cell population;stem cells;synergism;Technology;Testing;Time;tissue regeneration;tissue repair;Tissues;tool;TP53 gene;transcription factor;transcriptomics;Variant;Work


NIH_SPENDING_CATS: Aging;Genetics;Human Genome;Neurosciences;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: BRUNET, ANNE  (contact)

PROJECT_TERMS: Adult;Affect;Age;aged;Aging;aging brain;aging clocks;Alzheimer's Disease;animal old age;Astrocytes;Blood;Brain;cell type;Cells;Cerebrospinal Fluid;Chromatin;Collaborations;CRISPR screen;CRISPR/Cas technology;design;Deterioration;diet and exercise;dietary restriction;Disease;Endothelial Cells;Environment;epigenome;Exercise;Exhibits;experimental study;functional restoration;Genetic Transcription;genome-wide;glucose metabolism;Goals;In Vitro;in vivo;Individual;injury and repair;Intervention;Learning;Lipids;Liquid substance;machine learning model;Maps;Mass Spectrum Analysis;Memory;Metabolic;Metabolism;metabolome;metabolomics;Molecular;Neighborhoods;nerve stem cell;Nervous System;Neurodegenerative Disorders;neurogenesis;Neurons;old mice;Oligodendroglia;programs;Proteomics;regenerative;Regimen;Regulation;Rejuvenation;repaired;Resolution;response;sensor;single-cell RNA sequencing;spatial relationship;stem cell aging;stem cell function;stem cell niche;stem cells;subventricular zone;synergism;Technology;Testing;Tissues;transcriptome;transcriptomics;Work


NIH_SPENDING_CATS: Aging;Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: GOODELL, MARGARET A. (contact)

PROJECT_TERMS: 2 year old;Ablation;Acceleration;Affect;Age;age acceleration;age-related disease;aged;Aging;aging related;aging related disease;Animal Model;Atherosclerosis;Biological Assay;Blood Cells;cancer risk;Candidate Disease Gene;cell type;Cells;Chronic Obstructive Pulmonary Disease;Clonal Evolution;Clonal Hematopoietic Stem Cell;Collaborations;Data;deep sequencing;Development;Disease;Distal;DNA Modification Methylases;DNMT3a;Engraftment;Environment;experience;Experimental Models;experimental study;Genes;Genetic Variation;Gout;healthspan;Heart failure;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;hematopoietic differentiation;Hematopoietic stem cells;Hematopoietic System;Human;human tissue;improved;Infiltration;Kinetics;Loss of Heterozygosity;Macrophage;Mediating;Mediator;Modeling;Molecular;Mouse Strains;multiple omics;Mus;mutant;Myelogenous;Myeloid Cells;normal aging;novel therapeutic intervention;Obesity;old mice;Osteoporosis;Pancreas;Phenotype;Prevalence;Proteomics;regeneration potential;Regulation;Risk;Sampling;single cell sequencing;Somatic Mutation;stem cell aging;stem cell population;stem cells;Stroke;Testing;tissue stem cells;Tissues;Transplantation;Variant


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Neurosciences;Prevention;Rare Diseases;Rehabilitation;Sleep Research;Uterine Cancer;Vaginal Cancer;Women's Health Research

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE  Sleep disturbance is a prominent concern among gynecologic cancer survivors with severe and negative implications for health-related quality of life (HRQOL); however, leading non-pharmacologic sleep interventions often do not maximally benefit this population, possibly due to high treatment burden. The proposed study will identify barriers and facilitators of treatment adherence, and optimize a behavioral intervention to diminish sleep disturbance, increase HRQOL, and reduce symptom burden among gynecologic cancer survivors. This study will yield an improved treatment package to address the prevalent and impactful concern of sleep disturbance among gynecologic cancer survivors.

PI_NAMEs: FOX, RINA S (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: actigraphy;Address;Adherence;Affect;Aftercare;Automobile Driving;Beds;Behavior Therapy;Behavioral;behavioral sleep intervention;biobehavior;Biometry;Cancer Control;Cancer Survivor;Cancer Survivorship;career development;circadian;circadian biology;Circadian Dysregulation;Circadian Rhythms;Clinical;Clinical Investigator Award;Cognitive;Cognitive Therapy;Data;Depressed mood;design;Development Plans;Disease;efficacy evaluation;Elements;Eligibility Determination;experience;Fatigue;Feedback;follow-up;Foundations;Funding;Future;Goals;Gynecologic Oncology;health related quality of life;High Prevalence;Homeostasis;Impaired cognition;improved;improvement on sleep;Individual;innovation;Interdisciplinary Study;Intervention;intervention delivery;intervention effect;Interview;Israel;Light;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;Measures;Mediating;Medicine;Melatonin;Mentors;Mentorship;Methodology;Modeling;multidisciplinary;multiphase optimization strategy;Nature;Nonpharmacologic Therapy;Outcome;Outcome Study;Pain;Participant;Patient Self-Report;Patients;Periodicity;personalized intervention;Phase;phase 1 study;Population;post intervention;primary outcome;Procedures;Process;programs;Protocols documentation;psychosocial;Qualitative Methods;Qualitative Research;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;recruit;reduce symptoms;Relaxation Therapy;Reporting;Research;Research Methodology;Research Personnel;retention rate;Role;Sampling;secondary outcome;Sleep;sleep difficulty;Sleep disturbances;sleep health;sleep quality;sleep regulation;Sleeplessness;standard care;Stimulus;Structure;Survivors;Symptom Burden;Testing;therapy development;Time;Training;treatment adherence;treatment effect;Treatment Efficacy;trial design;urinary;Urine;Work;Wrist

PROJECT_TITLE: Improving sleep in gynecologic cancer survivors

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Prevention;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Worldwide there are estimated to be 2.9 million cholera cases annually and 95,000 deaths in cholera-endemic countries. The risk for cholera is 30 times higher for individuals living in close proximity to cholera patients during one week period after the index patient seeks care at a health facility. Given these findings, effective targeted water, sanitation, and hygiene (WASH) interventions are urgently needed to reduce cholera for this high risk population; this study will design, implement, and evaluate a scalable, theory and evidence based ring WASH intervention to reduce cholera infections and increase sustained WASH behaviors in transmission hotspots around cholera cases in Bangladesh.

PI_NAMEs: GEORGE, CHRISTINE MARIE (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Area;arm;Bangladesh;Bangladeshi;Behavior;care seeking;Cessation of life;Chlorine;Cholera;Clinical;Country;Dehydration;design;Diarrhea;Disease Outbreaks;disorder control;drinking water;Educational workshop;effectiveness evaluation;Effectiveness of Interventions;Evaluation;evidence base;Family;Focus Groups;General Population;Genetic;genome sequencing;Government;Government Officials;Handwashing;Health;Health care facility;high risk;high risk population;Home visitation;Hospitalization;Hospitals;Household;Hygiene;implementation intervention;improved;indexing;Individual;Intervention;Interview;Learning Module;Letters;member;meter;mHealth;Oral;Participant;Patient-Focused Outcomes;Patients;Perception;Phase;Policies;post intervention;Prevention;primary outcome;programs;prospective;Psychosocial Factor;Publishing;Randomized;Randomized, Controlled Trials;Recommendation;Rehydration Solutions;Research;Resource-limited setting;Risk;Sanitation;secondary outcome;Soaps;spatiotemporal;Standardization;Text Messaging;theories;therapy development;Time;transmission process;two-arm study;Vibrio cholerae;Vibrio cholerae infection;Visit;Voice;Water;water quality;water treatment;welfare;whole genome;Work

PROJECT_TITLE: A Ring Water, Sanitation, and Hygiene Intervention to Reduce Cholera in Hotspots in Bangladesh

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention

PHR: Project Narrative PUBLIC HEALTH RELEVANCE: Annually around the world, millions of old (and even young) people cared for in Intensive Care Units (ICUs) suffer through a period of confusion or delirium. These ICU survivors have new life-altering, long-lasting, and often permanent cognitive impairment, which looks like Alzheimer’s disease and/or related dementias. This BRAIN-ICU-2 Study [Bringing to light the Risk factors And Incidence of Neuropsychological dysfunction (dementia) in ICU Survivors, 2nd Study] will define the relationship between ICU delirium and dementia, will explain this unfortunate and life-changing brain damage in ICU survivors, and will pave the way for preventive programs, strategic rehabilitation, and targeted future interventions.

PI_NAMEs: ELY, E WESLEY (contact);JEFFERSON, ANGELA L.;PATEL, MAYUR B

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acute;Address;Admission activity;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Apolipoprotein E;Atrophic;Autopsy;Axon;Biological Markers;Brain;brain abnormalities;Brain Diseases;Brain Injuries;Caring;cerebral atrophy;Cerebrospinal Fluid;Cerebrovascular Disorders;Cessation of life;Climacteric;Clinical;clinical risk;Cognitive;cognitive recovery;cognitive rehabilitation;cognitive reserve;cognitive testing;cohort;comorbidity;Confusion;confusion assessment method;Consensus;Consent;cost;Data;Delirium;Dementia;Development;Diagnosis;Diagnostic;diagnostic tool;Disease;Drug Exposure;Education;Endothelium;Enrollment;executive function;Family;follow-up;frailty;frontal lobe;Functional disorder;functional outcomes;Funding;Future;health care settings;Healthcare;Hippocampus;Histopathology;HMGB1 gene;Hospitals;imaging biomarker;Immobilization;Impaired cognition;Incidence;Infarction;Inflammation;Injury;Intensive Care Units;Intervention;Investigation;Knowledge;Leadership;Learning;Length of Stay;Life;Link;Location;Magnetic Resonance Imaging;Maintenance;Measures;Mediating;Medical;Memory;microvascular pathology;modifiable risk;mortality;Nerve Degeneration;Neurofibrillary Tangles;neuroimaging;neuroinflammation;neuropathology;Neuropsychology;Occupations;Outcome;participant enrollment;Pathologic;Pathology;Pathway interactions;Patients;Perfusion;Persons;Phenotype;Plasma;Plasminogen Activator Inhibitor 1;Population;Preventive;programs;protein TDP-43;Proteins;public health relevance;Publishing;Quality of life;Recovery;Rehabilitation therapy;repository;Research;resilience;Respiratory Failure;response;Risk;Risk Factors;Sampling;Science;secondary analysis;Sepsis;Shock;Structure;Surgical Intensive Care;Survivors;survivorship;Synapses;tau Proteins;Testing;Time;Universities;vascular injury;Ventilator;white matter;White Matter Disease;Work

PROJECT_TITLE: BRAIN-ICU-2 Study: Bringing to Light the Risk Factors And Incidence of Neuropsychological Dysfunction (Dementia) in ICU Survivors, 2nd Study


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: HOUSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: RICE UNIVERSITY

PHR: The proposed research is relevant to public health because it will result in the development of a serological test for accurate detection of Chagas infection. Existing Chagas serological tests are prone to inconclusive or false- negative test results, which can lead to increased disease transmission and life-threatening illness due to misdiagnosis. Thus, the proposed research is relevant to NIAID’s mission by advancing neglected tropical disease research through the development of new diagnostics to improve the diagnosis of individuals with Chagas disease, which will ultimately improve patient outcomes.

PI_NAMEs: LILLEHOJ, PETER B (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: accurate diagnostics;Acute;acute infection;Antibodies;antigen detection;Antigens;Argentina;Biological Assay;Blood;Blood donor;Blood Transfusion;Cardiomyopathies;Chagas Disease;Chronic;chronic infection;Chronic Phase;Collection;Colombia;Country;cross reactivity;Data;design;Detection;detection limit;detection method;detection sensitivity;Development;Diagnosis;Diagnostic;diagnostic assay;Disease;disease transmission;Drops;Ecuador;effectiveness evaluation;Enzyme-Linked Immunosorbent Assay;Enzymes;Equipment;Exhibits;Generations;Geography;Goals;Guatemala;Healthcare Systems;Heart Arrest;Heart failure;Honduras;Human;Immobilization;Immunoassay;Immunoglobulin G;improved;Individual;Infection;innovation;Laboratories;Latin America;Leishmania;Libraries;Life;Magnetism;Measurement;Mexico;Microscopy;Mission;Morbidity - disease rate;mortality;nano;National Institute of Allergy and Infectious Disease;neglected tropical diseases;novel diagnostics;Outcome;Pan American Health Organization;Parasitemia;Parasites;pathogen;Patient-Focused Outcomes;Patients;Performance;Persons;Phase;Process;Proteins;Protocols documentation;prototype;Public Health;Reader;Recombinants;Recommendation;Reporter;Research;Resources;Sampling;screening;Sensitivity and Specificity;Serology;Serology test;Serum;Source;Specificity;Symptoms;Techniques;Test Result;Testing;Time;Trypanosoma cruzi;United States

PROJECT_TITLE: Serological test for detecting all geographical variances of Trypanosoma cruzi infection

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BIRMINGHAM

ORG_NAME: BIRMINGHAM VA MEDICAL CENTER

ORG_STATE: AL

PHR: Hypertension afflicts more than 30% of the adult population and is one of the most common causes of progressive chronic kidney disease (CKD) in the US. There is a disproportionate increased prevalence of CKD in veterans compared with the general population and nearly half have hypertension. The percentage of hypertensive patients who ultimately develop ESKD has remained constant despite treatment. The present application proposes to fill gaps in understanding how the microvasculature of the kidney is predisposed to hypertension-induced changes that lead to detrimental arteriolar remodeling, accompanying glomerular injury, and development of progressive CKD.

PI_NAMEs: SANDERS, PAUL W. (contact)

PROJECT_TERMS: Adult;Albuminuria;Angiotensin II;Animal Model;arteriole;Attention;Behavior;Birds;blood pressure elevation;Blood Pressure Monitors;Blood Vessels;CCL2 gene;Cell Differentiation process;cell growth;chemokine;Chronic Kidney Failure;Dahl Hypertensive Rats;Defect;Development;End stage renal failure;Endothelial Cells;Event;Extracellular Matrix;Family;Fibrosis;Functional disorder;Gelatinase B;General Population;Glomerular Filtration Rate;glomerulosclerosis;Homeostasis;Homologous Gene;Human;Hypertension;hypertension treatment;hypertensive;Hypoxia;Impairment;improved;Inflammation;Inflammatory;Injury;insight;Investigation;Kidney;Kidney Diseases;Kidney Transplantation;kidney vascular structure;Ligands;Macrophage;Mediating;member;military veteran;Modeling;Molecular;Mutation;novel;novel strategies;Oncogenes;Pathogenesis;Patients;Perivascular Fibrosis;Play;podocyte;Population;Predisposition;Prevalence;Process;Production;Publishing;Rattus;Renal function;Renal Hypertension;response;Role;Series;Smooth Muscle;Smooth Muscle Myocytes;Telemetry;Time;Tissues;transcription factor;transplant model;vascular inflammation;Vascular remodeling;Vascular Smooth Muscle;Veterans;Virus

PROJECT_TITLE: Vascular Mechanisms of Hypertensive Nephropathy


ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

PHR: Narrative Statement To date, few clinical trials for tauopathy have specifically targeted pathological tau, yet neurofibrillary tangles are the diagnostic neuropathological hallmark of AD that is most closely associated with cognitive decline. To help fill this gap, we propose to develop novel neuroprotective strategies that target pathological tau in AD and related dementias. Specifically, we propose to develop biological lead molecules antagonizing MSUT2 binding to RNA. These novel tool agents will provide a proof-of- concept demonstration that inhibiting MSUT2 can reverse pathological tau deposition, and they will support mechanistic investigation of MSUT2 as a critical modulator of pathological tau.

PI_NAMEs: KRAEMER, BRIAN C. (contact)

PROJECT_TERMS: adeno-associated viral vector;Affinity;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;antagonist;Antibodies;Binding;Biological;Biological Products;Biological Response Modifier Therapy;biophysical properties;Brain;Brain Diseases;brain tissue;Caenorhabditis elegans;Cell model;Cells;Clinical Trials;Dementia;Deposition;Development;Diagnostic;Disease;Epitopes;Exhibits;Future;gene conservation;gene therapy;Goals;High-Throughput Nucleotide Sequencing;Human;Immunization;Impaired cognition;Intervention;Intrabody;Investigation;Knowledge;Lead;lead candidate;Lesion;Measurement;Measures;Memory;mouse model;Mus;nanobodies;Nerve Degeneration;Neurofibrillary Tangles;neuroinflammation;Neurons;neuropathology;neuroprotection;neurotoxicity;novel;Pathologic;Pathology;Peptide Mapping;Phenotype;Poly(A)+ RNA;Predisposition;Production;Proteins;RNA;RNA Binding;RNA Recognition Motif;RNA-Binding Proteins;Severities;symptom treatment;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic;therapeutic candidate;therapeutic target;tool;Toxic effect;translational study;Validation;Viral Vector;Work

PROJECT_TITLE: Developing MSUT2 Nanobodies for Targeting Pathological Tau in Alzheimer's Disease


ORG_CITY: MOUNTAIN HOME

ORG_NAME: JAMES H QUILLEN VA MEDICAL CENTER

PHR: PTSD has a greater incidence rate in Veterans compared to the general population. Furthermore, Veterans with PTSD are almost twice as likely to develop issues with alcohol abuse and alcohol use disorder (AUD). Recent evidence indicates that the brain areas associated with PTSD and drug addiction have many common characteristics. As a result, there is evidence that PTSD symptoms contribute to the development of alcoholism, and alcohol interferes with the treatment of PTSD. Unfortunately, the treatments that are currently being used to treat individuals with PTSD and AUD are not effective. Thus, there is a great need to better understand how the brain is changed in this disorder. In doing so, we can develop new treatment drugs that can help these individuals manage their symptoms and lead a normal life despite having experienced a traumatic event.

PI_NAMEs: GASS, JUSTIN T (contact)

PROJECT_TERMS: Acute;Alcohol abuse;alcohol behavior;alcohol comorbidity;Alcohol consumption;alcohol exposure;alcohol seeking behavior;alcohol use disorder;Alcoholism;Alcohols;Amygdaloid structure;Animal Model;Anxiety Disorders;Area;Attenuated;Behavior;Behavior Control;Behavioral;Behavioral Mechanisms;behavioral pharmacology;Biological Assay;Brain;Brain region;Characteristics;Chemosensitization;Chronic;Clinical;Cognitive;Cognitive deficits;cognitive function;cognitive process;comorbidity;Complex;coping;Data;Decision Making;Development;Disease;Drug abuse;Drug Addiction;Drug usage;executive function;experience;experimental study;Exposure to;Extinction;flexibility;Foundations;Fright;Functional impairment;Future;General Population;glutamatergic signaling;Glutamates;Goals;GRM5 gene;heart rate variability;high risk sexual behavior;Human;Impaired cognition;Implant;improved;Incidence;Individual;Inflammation;Inflammatory;innovation;Intake;Intervention;Investigation;Lead;Learning;learning extinction;Life;Link;Measurement;Measures;Mediating;Memory;Mental disorders;military veteran;Modeling;Monitor;neural circuit;neuroinflammation;Neurologic;neuromechanism;Neurons;new therapeutic target;novel;optogenetics;Pharmaceutical Preparations;pharmacologic;Physiological;Population;Post-Traumatic Stress Disorders;Prefrontal Cortex;prevent;problem drinker;Process;Prognosis;Rattus;Recovery;Relapse;Risk Behaviors;Risk Factors;Self-Injurious Behavior;sensor;Severities;Stress;stress reduction;stressor;substance use;Symptoms;targeted treatment;Techniques;Technology;Telemetry;Testing;Training;Trauma;traumatic event;Veterans

PROJECT_TITLE: mGlu5 modulation prevents and attenuates deficits in a model of PTSD/AUD comorbidity


ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Narrative: Immunotherapy is changing cancer care. There is tremendous hope that it will cure cancer in Veterans even when the cancer has spread or metastasized. Unfortunately, most Veterans do not respond to immunotherapy. Therefore, we aim to design more effective treatments by combining radiotherapy, and immunotherapy. These therapies interact in the tumor because of tumor cell death. The immune system reacts differently to dead cells based on how they died, which makes it important to understand how best to kill a tumor cell. With this information, we hope to make immunotherapy work better and improve the lives of Veterans with cancer.

PI_NAMEs: GREEN, MICHAEL DANIEL (contact)

PROJECT_TERMS: Abscopal effect;adaptive immune response;Agonist;antagonist;anti-tumor immune response;Antigen-Presenting Cells;Binding;calreticulin;cancer care;Cancer Model;cancer therapy;Cause of Death;CD8B1 gene;Cell Count;Cell Death;Cell Death Induction;Cell Line;Cell Physiology;Cells;Colorectal Cancer;combinatorial;Combined Modality Therapy;cytotoxic;Data;Dendritic Cells;design;Disease;effective therapy;effector T cell;genetic manipulation;Goals;Heat shock proteins;Immune;immune checkpoint blockade;Immune response;Immune system;immunogenic;immunogenic cell death;immunogenicity;Immunologic Stimulation;Immunologics;immunoregulation;Immunotherapy;improved;Inflammation;Inflammatory;innate immune sensing;innovation;Lesion;Link;Lipid Peroxidation;Lipids;Macrophage;Malignant Neoplasms;Mediating;Mediator;Melanoma;Melanoma Cell;Melanoma Tumor;Metastatic Melanoma;Modality;Modeling;Molecular;Motility;Natural Immunity;Neoplasm Metastasis;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;oxidation;oxidized lipid;Pattern;pharmacodynamic biomarker;pharmacologic;Publishing;Radiation;Radiation therapy;radio observations;rational design;Reaction;Renal Cell Carcinoma;Research;response;Shapes;Signal Pathway;subcutaneous;synergism;T cell response;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Toll-like receptors;trafficking;Treatment Efficacy;treatment strategy;tumor;Tumor Immunity;Tumor Promotion;Veterans;Work

PROJECT_TITLE: Enhancing Ferroptosis to Augment Responses to Immune Checkpoint Blockade


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The molecular mechanisms underlying the pathogenic nature of APOE4 in Alzheimer’s disease (AD) are not fully elucidated. In previous funding period, we have uncovered a novel regulatory mechanism of miR-195 targeted at APOE4-associated cognitive deficits and lysosomal defects in AD. Our preliminary results further support the role of miR-195 as an anti-inflammatory miRNA in regulating microglial function. Therefore, we will characterize in this renewal application, the regulation of microglial function in AD by miR-195 with in vivo studies of humanized APOE mouse models, ex vivo microglial culture and 3-D co-culture system, and validation studies of human brain samples. The scRNA-seq data from mouse brains and RNA-seq/miRNA-seq data from mouse microglial and 3-D co-culture will be integrated to perform high resolution multiscale network modeling and to elucidate novel molecular signatures driven by miR-195 protective against APOE4-induced neuro-inflammation.

PI_NAMEs: CAI, DONGMING  (contact)

PROJECT_TERMS: 3-Dimensional;Age Months;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Animals;Anti-Inflammatory Agents;Antiinflammatory Effect;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Attenuated;Autopsy;Axon;Behavioral;Brain;brain cell;Brain region;Cells;Chelating Agents;Chronic;Coculture Techniques;Cognitive;Cognitive deficits;cognitive performance;cohort;Complex;Copper;Cuprizone;cytokine;Data;Data Set;Defect;Demyelinations;Development;dietary control;Disease;Disease Progression;Down-Regulation;Enzymes;Etiology;Exhibits;exosome;Experimental Models;Female;follow-up;Functional disorder;Funding;Gene Expression;Genes;genetic risk factor;glial activation;Goals;Hippocampus;Homeostasis;Human;Impairment;in vivo;induced pluripotent stem cell;Inflammation;Inflammatory;Inflammatory Response;Injections;inorganic phosphate;knock-down;Knock-in;Knock-in Mouse;Ligands;Lipopolysaccharides;male;Micro Array Data;Microglia;MicroRNAs;miRNA expression profiling;Modeling;Molecular;Molecular Profiling;Morphology;motor deficit;mouse model;Mus;Myelin;Nature;network models;neuroinflammation;Neurons;novel;overexpression;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Phagocytes;Phenotype;Phospholipids;Pilot Projects;prevent;protein expression;recruit;Regulation;Resolution;response;Role;Sampling;Senile Plaques;single-cell RNA sequencing;SYNJ1 gene;System;targeted treatment;tau Proteins;Testing;Time;transcriptome sequencing;TREM2 gene;uptake;validation studies;vector;Viral;Women's study

PROJECT_TITLE: MicroRNA Regulation of Phospholipid Homeostasis in Alzheimer's Disease Pathogenesis


ORG_CITY: MATHER

ORG_NAME: VA NORTHERN CALIFORNIA HEALTH CARE SYS

PHR: Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are common problems among U.S. Veterans. People with PTSD are more likely to develop AUD, and it is often harder to treat someone with both PTSD and AUD than with either illness alone. In fact, people with both PTSD and AUD generally have more severe symptoms and higher risk of suicide. Current treatments for PTSD and AUD are not helpful for many people, and more work is needed to find the causes of these illnesses, especially those that contribute to both. In our proposal, we will build upon the tremendous strides in understanding the genetic causes of these illnesses to identify novel treatment targets for them. Furthermore, by studying both conditions at the same time we are more likely to identify common contributors to both illnesses that could be used to tailor treatment for each illness alone and both illnesses when they occur together.

PI_NAMEs: WINGO, ALIZA PHAM (contact)

PROJECT_TERMS: Address;alcohol use disorder;Alleles;Amygdaloid structure;Anterior;Brain;Brain region;causal variant;cingulate cortex;Clinical Trials;Code;comorbidity;Complex;Data;Data Set;Development;Disease;disease model;Drug Targeting;Finding by Cause;Funding;Gene Frequency;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;Genetic study;genetic variant;genome wide association study;genome-wide;genomic locus;Goals;high risk;Hippocampus;Human;Human Genetics;Individual;individualized medicine;insight;Major Depressive Disorder;Mediating;Mediation;Mendelian randomization;Mental Depression;Mental disorders;Mental Health;Messenger RNA;mRNA Expression;Nature;Neurosciences;novel;novel therapeutics;Nucleus Accumbens;Outcome;Participant;Patients;Personal Satisfaction;Persons;Post-Translational Regulation;Post-Traumatic Stress Disorders;posttranscriptional;precision medicine;Prefrontal Cortex;Prognosis;programs;protein biomarkers;protein expression;Proteins;Proteome;Proteomics;psychiatric genomics;Publishing;Quantitative Trait Loci;regional difference;Regulation;Research Personnel;Role;Single Nucleotide Polymorphism;Site;statistics;suicidal risk;Susceptibility Gene;Symptoms;Techniques;Testing;therapeutic development;therapeutic target;Time;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Variant;Veterans;Weight;Work

PROJECT_TITLE: Identifying Novel Brain Proteins Contributing to PTSD and Alcohol Use Disorder


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Microbiome;Natural Products;Neurosciences;Substance Misuse

ORG_CITY: FORT COLLINS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative Cannabis is the most commonly used drug among people who drink alcohol, and conflicting evidence suggests that cannabinoids (the chemical constituents of the cannabis plant, including delta-9-tetrahydrocannabinol [THC]) may confer both harms and benefits on the symptoms of alcohol use disorder (AUD). Animal studies suggest the effects of cannabis among heavy drinkers may be partially due to the impact of THC on the microbiota-gut-brain axis (MGBA; which refers to the bidirectional communication between the digestive, immune, and central nervous systems), however no human studies have explicitly explored this question. This observational study will inform our understanding of the risks and potential harm-reduction benefits of cannabis among heavy drinkers by investigating the effects of THC in legal-market cannabis on acute and daily alcohol consumption, AUD symptoms, and MGBA function among heavy drinking, regular cannabis users.

PI_NAMEs: KAROLY, HOLLIS C (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Acute;Agonist;Alcohol consumption;alcohol craving;alcohol effect;alcohol exposure;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;Animals;Applications Grants;Area;Attenuated;Bacteria;Bifidobacterium;Biological;Biological Markers;Biometry;Blood;Brain;Brain region;Cannabinoids;Cannabis;Cannabis policy;Cannabis retail;career;Cell Culture Techniques;Central Nervous System;Chemicals;CNR1 gene;Cognition;Cognitive;cognitive function;Communication;Consumption;craving;cytokine;Data;Data Set;Dependence;design;diaries;Dose;drinking;Drug usage;endogenous cannabinoid system;Ethanol;Etiology;Future;Goals;gut microbes;gut microbiota;gut-brain axis;Harm Reduction;Heavy Drinking;Home;Human;human data;Immune;immune function;Immune system;Immune System Diseases;Impaired cognition;Impairment;Impulsivity;Individual;Inflammation;Inflammatory;innovation;Institutional Review Boards;Intestinal permeability;Legal;Link;Literature;liver inflammation;Maintenance;marijuana use;marijuana user;Marketing;Measures;Mediating;Medical;Medical Marijuana;Mentors;Mentorship;Methods;microbiota;microbiota-gut-brain axis;Mus;National Institute on Alcohol Abuse and Alcoholism;neurobehavioral;neurobehavioral test;novel;Observational Study;Outcome;patient oriented;Patients;Pattern;Performance;Persons;pharmacologic;Pharmacology;Phase;Phenotype;Physiological;Plants;pre-clinical;Proteobacteria;Rattus;Recreation;recruit;Reporting;Research;Risk;Rodent;Role;sample collection;Sampling;Self Administration;Signal Transduction;skills;Smoke;Strategic Planning;Symptoms;System;Testing;Tetrahydrocannabinol;Time;Training;translational research program;United States National Institutes of Health;Visit;Work;zonulin

PROJECT_TITLE: Exploring the Effects of Cannabinoids on Alcohol Consumption and the Microbiota-Gut-Brain Axis

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Down Syndrome;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Lung;Pediatric

PHR: Project Narrative Children with Down syndrome (DS), irrespective of having other risk factors, are at increased risk for respiratory syncytial virus (RSV) infection. Whether children with DS benefit from RSV immunoprophylaxis, the only currently available preventive therapy for RSV, is not known. This study, the largest study ever conducted, is adequately powered and aims to determine the short- and long-term effectiveness of RSV immunoprophylaxis in children with DS; it will provide necessary information regarding effectiveness of RSV immunoprophylaxis that will impact policy and potentially improve health in children with DS.

PI_NAMEs: WU, PINGSHENG  (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: 6 year old;Academy;Adaptive Immune System;Adherence;Adverse event;American;Anatomy;Asthma;Birth;Child;Childhood;Chromosome 21;Chronic lung disease;Clinical;clinical care;cohort;Cohort Studies;Congenital chromosomal disease;congenital heart abnormality;cost;cost effectiveness;Costs and Benefits;Data;Death Rate;demographics;Department of Defense;Disease;Down's Syndrome;Effectiveness;efficacy evaluation;Eligibility Determination;Enrollment;Guidelines;Health;Health Care Visit;Healthcare Systems;hemodynamics;high risk population;Hospitalization;Human;Immune system;immunoprophylaxis;improved;infancy;Infant;Infection;infection rate;Innate Immune System;Knowledge;Lead;Life;Lower Respiratory Tract Infection;Lung;Medicaid;Military Personnel;Morbidity - disease rate;mortality;Observational Study;Outcome;Patients;Pediatrics;pharmacologic;Physiological;Policies;Policy Maker;Population;population based;post-market;Premature Birth;Prevalence;prevent;Preventive therapy;programs;Qualifying;randomized, clinical trials;Research;Research Design;respiratory;Respiratory Disease;respiratory morbidity;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;response;Risk;Risk Factors;Safety;Socioeconomic Factors;Tennessee;Testing;Variant;Viral;Vulnerable Populations;Wheezing

PROJECT_TITLE: The effectiveness of RSV immunoprophylaxis on the short- and long- term respiratory morbidity in children with Down syndrome


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Influenza;Nanotechnology;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: AMES

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE Age-related impairments of immune responsiveness result in reduced efficacy of influenza vaccination in older adults. The overall objective of this project is to develop an efficacious influenza nanovaccine for older populations, and to understand the mechanisms by which rational selection of biomaterials and co-adjuvants in vaccines can enhance immune capabilities of aged individuals.

PI_NAMEs: KOHUT, MARIAN L (contact);NARASIMHAN, BALAJI

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: adaptive immunity;Adjuvant;Adult;age related;age-related disease;aged;Aging;aging population;amphiphilicity;Antibodies;Antibody Formation;Antibody Response;Antibody titer measurement;Antigen Presentation;Antigens;arm;B-Cell Activation;B-Lymphocytes;Biocompatible Materials;Biology of Aging;Blood;CD8-Positive T-Lymphocytes;cell age;cell motility;Cell Physiology;Cellular Immunity;Cellular Metabolic Process;Cessation of life;Characteristics;Clinical Trials;copolymer;Data;Defect;Dendritic Cells;design;Development;Dose;draining lymph node;flexibility;Formulation;Goals;Health;Helper-Inducer T-Lymphocyte;Hemagglutinin;hospitalization rates;Human;human old age (65+);Immune;Immune response;Immune system;Immunity;Immunization;immunogenicity;Impairment;improved;In Vitro;Infection;Inflammation;Inflammatory;Influenza;Influenza A virus;influenza infection;Influenza vaccination;influenza virus vaccine;influenzavirus;insight;Lead;Lung;lymph nodes;Measures;Memory;Metabolic;metabolic profile;Micelles;Mitochondria;Modeling;mortality;nanoparticle;nanopolymer;nanovaccine;nonhuman primate;novel;novel strategies;Nucleoproteins;old mice;older adult;Older Population;Outcome;Outcome Measure;Oxidative Phosphorylation;peripheral blood;Phenotype;Polyanhydrides;Population;preservation;primary outcome;Public Health;Publishing;rational design;Recombinants;Research;Respiration;respiratory;response;Risk;Role;Route;safety study;self assembly;Serum;Spleen;T cell response;T memory cell;T-Cell Activation;T-Lymphocyte;Testing;Underserved Population;vaccine delivery;vaccine efficacy;vaccine formulation;vaccine platform;vaccine response;vaccine-induced immunity;Vaccines;Viral Load result;Virus Diseases;young adult

PROJECT_TITLE: Combination nanovaccine-based immunization against influenza virus in the aged: immunity and protection

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


FUNDING_MECHANISM: OTHERS

ORG_CITY: Decatur

ORG_STATE: GA

PHR: S. pneumoniae is the leading cause of community acquired pneumonia, the most common infectious cause of death among the veteran population. Despite a rigorous pneumococcal vaccination program, S. pneumoniae remains a major health threat to veterans. The severity of pneumococcal infection depends on the interaction between bacterial and host factors. S. pneumoniae infection induces oxidative stress in the host and leads to epithelial dysfunction, tissue injury and a dysregulated inflammatory response. Preliminary research included in this grant suggests that oxidative mitochondrial DNA damage may play a role in mediating the pathogenicity of pneumococcal infection. This project proposes to investigate the bacterial and host factors that mediate mitochondrial DNA damage and repair. These translational studies will determine if therapies targeting enhancement of mitochondrial DNA repair can improve the host response to pneumococcal infection, thereby leading to clinical trials of this novel therapeutic strategy in veterans suffering from pneumococcal infection.

PI_NAMEs: MAURICE, NICHOLAS MICHAEL (contact)

PROJECT_TERMS: 8-Oxoguanine DNA Glycosylase;Antioxidants;Area;Attenuated;attenuation;Award;Bacteria;base;Base Excision Repairs;Bioenergetics;Biogenesis;Biology;career;career development;Cause of Death;Cell Death;cell injury;cell type;Cells;Chimeric Proteins;Cholesterol;Clinical;Clinical Research;Clinical Trials;Communicable Diseases;community acquired pneumonia;comorbidity;Critical Illness;Cytolysins;Data;Disease;DNA;DNA Damage;DNA glycosylase;DNA Repair;DNA Repair Enzymes;efficacious treatment;Elderly;Environment;Enzymes;Epithelial Cells;epithelial injury;Epithelium;Event;Faculty;Functional disorder;Funding;gain of function;Gene Delivery;Generations;Genetic;Goals;Grant;Guanine;Health;Host Defense;Human;Hydrogen Peroxide;Immune;immune function;Immune response;Immunization Programs;Impairment;improved;improved outcome;in vivo;in vivo Model;Infection;Inflammatory;Inflammatory Response;Injury;Innate Immune Response;insight;Integration Host Factors;International;knock-down;Life;Lipids;Lung;lung injury;Measures;Mediating;Medical center;medical schools;Mentors;Mentorship;Microbiology;migration;military veteran;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial genome;Morbidity - disease rate;mortality;multidisciplinary;Mus;mutant;Natural Immunity;new therapeutic target;novel;novel therapeutic intervention;Nuclear;Nucleotides;overexpression;Oxidation-Reduction;oxidative damage;oxidative DNA damage;Oxidative Stress;Oxidative Stress Induction;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;pharmacologic;Physicians;Pneumococcal Infections;Pneumococcal Pneumonia;Pneumonia;pneumonia model;Populations at Risk;pre-clinical;Predisposition;Process;Proteins;Pseudomonas aeruginosa;Publishing;Pyruvate Oxidase;Quality Control;Reactive Oxygen Species;repaired;Research;research and development;Research Personnel;Resistance;Respiratory System;response;Role;Scientist;Sepsis;septic patients;Severities;Severity of illness;Signal Transduction;skills;Streptococcus pneumoniae;Streptococcus pneumoniae plY protein;success;targeted treatment;Testing;tissue injury;Training;Training Programs;translational potential;translational study;treatment strategy;Universities;vaccine development;Veterans;Virulence;Virulence Factors;Work

PROJECT_TITLE: Novel Therapies Targeting Mitochondrial Pathways in Lung Epithelial Response to S. Pneumoniae Infection


ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

ORG_STATE: NY

PHR: Salt sensitive hypertension, a subset of essential hypertension, affects more than 15% of the adult U.S. population. Epidemiologic evidence suggests salt sensitive hypertension has a worse cardiovascular prognosis than salt resistant hypertension, but the mechanism underlying the poor prognosis is unknown. This difference in clinical outcome imply differences in the pathophysiology of hypertension. Investigations have suggested that elevated tissue cholesterol may contribute to activated Na transport in the kidney and reduced release of natriuretic molecules, raising systemic blood pressure. Tissue cholesterol also stimulates inflammation which may explain the excess mortality observed with sodium sensitivity. In this research application, we develop a novel mouse model where ABCA1, a tissue cholesterol efflux protein, is ablated from sodium transporting tubular cells to determine whether high cholesterol content in tubular cells leads to salt sensitive hypertension, inflammation and apoptosis.

PI_NAMEs: ROHATGI, RAJEEV  (contact)

PROJECT_TERMS: Ablation;absorption;Active Biological Transport;Adult;Affect;Amino Acids;Apolipoprotein E;Apolipoproteins;Apoptosis;Atherosclerosis;ATP-Binding Cassette Transporters;autocrine;Automobile Driving;Avidity;Blood Pressure;Cardiovascular system;Cell Nucleus;Cells;Ceramides;Cholesterol;Cilia;Clinical;Complex;Consensus Sequence;cyclooxygenase 2;Data;density;design;Development;Diet;dietary;Dinoprostone;Disease;Distal;Duct (organ) structure;Electrophysiology (science);Environmental Risk Factor;Epidemiology;epithelial Na+ channel;Epithelium;Essential Hypertension;Excess Mortality;Excretory function;Functional disorder;Genetic;Genetic Polymorphism;High Density Lipoproteins;Human;Hypertension;Inflammation;Inflammatory;inflammatory marker;Investigation;Kidney;Kidney Diseases;knock-down;Knock-out;Lead;Length;Ligands;Link;Lipid Peroxidation;Lipid Peroxides;Liquid substance;Low-Density Lipoproteins;Mediating;Membrane Microdomains;Methods;Mitochondria;Molecular;mortality;mouse model;Mus;Mutation;Natriuresis;Natriuretic Factors;Nephrons;NOS1 gene;NOS3 gene;novel;Organ;Outcome;Oxidative Stress;P2Y2 receptor;paracrine;Pathway interactions;pharmacologic;Phenotype;Physiological;Population;Pre-Eclampsia;premature atherosclerosis;Prognosis;Proteins;recruit;Repression;Research;Resistance;Resistant Hypertension;Respiration;response;Risk;Risk Factors;risk variant;salt sensitive hypertension;saluretic;Serum;shear stress;Signal Transduction;Sodium;Sodium Chloride;Sphingomyelinase;Sphingomyelins;SR-BI receptor;Stress;symporter;Systemic blood pressure;Systemic hypertension;Tangier Disease;Testing;Tissues;TLR2 gene;TLR4 gene;transcriptome sequencing;Tubular formation;urinary;Variant

PROJECT_TITLE: Lipid Rafts: Mechanosensors of the distal nephron


ORG_NAME: BALTIMORE VA MEDICAL CENTER

PHR: Venous thrombus embolism (VTE) which includes deep venous thrombosis (DVT) is a common and serious clinical problem. Despite standard anticoagulant therapy, 25%-50% of patients with clots in the deep veins of the arms and legs progress to chronic post-clot problems resulting in significant disability, loss of productivity, and healthcare costs. DVT and its complications have increased in the Veteran population over the last decade. A recent study of almost 500,000 surgeries performed at the Department of Veterans Affairs Medical Centers found that over half of the surgical patients developed VTE after surgery within 90 days. Patients who display faster thrombus resolution have a lower risk of complications and better prognosis than those patients whose thrombus resolves much slower. The goal of this research is to better understand the inflammatory processes that regulate venous thrombus resolution, and to develop specific therapies to accelerate the resolution process for clinical management of DVT.

PI_NAMEs: ANTALIS, TONI M (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;Adjuvant Therapy;Adoptive Transfer;Affect;Agonist;Air;American;antagonist;Anti-Inflammatory Agents;Anticoagulant therapy;Anticoagulants;Anticoagulation;arm;Award;Biological Assay;Blood;Blood coagulation;Calibration;candidate marker;Cardiovascular Diseases;Cell Survival;Cells;Cessation of life;chemokine;Chronic;Clinical;Clinical Management;Clinical Research;clinically relevant;Coagulation Process;Competence;Complication;Constitution;cytokine;Data;deep vein;Deep Vein Thrombosis;Dehydration;disability;Disease;effective therapy;Embolism;Environment;Event;Experimental Models;experimental study;Fibrinolysis;Fibrosis;Foundations;Gene Expression;gene network;Genes;Genetic;genetic signature;Goals;Health;Health Care Costs;Hospitalization;Human;human old age (65+);Immobilization;Immune;Immune response;immunoregulation;improved;Inflammation;Inflammatory;inflammatory modulation;inhibitor;insight;Knowledge;Leg;Leukocytes;Longitudinal Studies;Macrophage;Malignant Neoplasms;Measurement;Mediating;Medical center;Methods;Migration Assay;Military Personnel;military veteran;Molecular;molecular marker;Morbidity - disease rate;mortality;mouse model;Mus;neutrophil;Neutrophil Activation;novel;novel therapeutics;Obstruction;Operative Surgical Procedures;Pain;Paralysed;Pathogenesis;Pathway interactions;Patients;Pattern;Peptide Hydrolases;Peptides;peripheral blood;Phenotype;Plasminogen Activator Inhibitor 2;Play;Postphlebitic Syndrome;potential biomarker;Pre-Clinical Model;premature;prevent;Process;productivity loss;Prognosis;prognostic value;programs;Property;Pulmonary Embolism;Recurrence;Regulation;Research;Resolution;Risk;Risk Factors;RNA Interference;Serine Proteinase Inhibitors;Serpins;Serum;severe injury;Signal Pathway;Skin;skin ulcer;Source;Swelling;Testing;Therapeutic;therapeutic evaluation;thrombolysis;thrombotic complications;Thrombus;Time;Tobacco use;transcriptome;translational potential;Trauma;Treatment Efficacy;United States Department of Veterans Affairs;Urokinase;urokinase inhibitor;Vascular remodeling;Venous;venous thromboembolism;Venous Thrombosis;Veterans

PROJECT_TITLE: Proteolytic Pathways in Venous Thrombus Resolution


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Social Determinants of Health;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Involvement with the criminal justice system, substance use, and infection with HIV and hepatitis C virus are syndemic in the United States. Despite this public health crisis, there is a relative dearth of clinical research aimed at improving treatment outcomes among CJ populations. To address this gap and increase the number and capacity of clinical scientists working with criminal justice-involved populations, we have established this clinical research training program based at the Providence-Boston Center for AIDS Research (CFAR) and in collaboration with the Brown University and Boston University Schools of Public Health.

PI_NAMEs: BECKWITH, CURT G (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Academic Medical Centers;Acquired Immunodeficiency Syndrome;Active Learning;addiction;Address;Advisory Committees;alcohol research;Alcohols;Area;Behavioral Medicine;Boston;career;Career Mobility;career networking;Clinical;Clinical Research;cohort;Collaborations;comorbidity;Criminal Justice;Data;didactic education;Disparity;Distance Learning;economic disparity;Education;education research;Educational workshop;educationally disadvantaged;Enrollment;Environment;Epidemic;Ethics;ethnic minority;Evidence based intervention;experience;Faculty;falls;Feedback;Fostering;Foundations;Funding;Future;General Population;Grant;Growth;Health;health care availability;Health Insurance;Health Policy;Hepatitis C;Hepatitis C virus;HIV;HIV/HCV;Home;Hospitals;Human Rights;implementation science;Imprisonment;improved;Individual;Infection;innovation;Institution;International;life span;Medical center;meetings;Mental Health;Mentors;Mentorship;Mission;National Institute of Drug Abuse;opioid epidemic;opioid overdose;Outcome;outreach;Pathway interactions;Peer Review;Persons;Pilot Projects;Population;Postdoctoral Fellow;pre-doctoral;Preventive Medicine;Prisoner;Professional Organizations;Program Evaluation;programs;Public Health;Public Health Schools;Qualifying;racial minority;recruit;Research;Research Methodology;Research Personnel;Research Training;response;Review Literature;Rhode Island;Scientist;skills;Solid;substance use;symposium;syndemic;System;Training;Training Programs;Treatment outcome;United States;United States National Institutes of Health;Universities;Vulnerable Populations;webinar;Writing

PROJECT_TITLE: The Lifespan/Brown Criminal Justice Research Program on Substance Use and HIV


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE This project seeks to generate a new strategy to stop development of Plasmodium falciparum in the Anopheles gambiae mosquito, the most important malaria vector. In this strategy Plasmodium parasites are killed with antimalarial drugs during their development in the mosquito by exposing female Anopheles to drug-treated surfaces such as mosquito nets. These studies will provide new effective tools to aid future malaria elimination efforts.

PI_NAMEs: CATTERUCCIA, FLAMINIA  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: absorption;Accounting;Affect;Africa South of the Sahara;Anopheles gambiae;Anopheles Genus;Anti-malarials;Artemisinins;asexual;atovaquone;Beds;Biological Assay;Bite;Blood;Burkina Faso;Cessation of life;Collaborations;Combined Modality Therapy;Culicidae;Cytochrome a;Cytochromes b;Deposition;design;Development;Disease;Drug Kinetics;Drug resistance;Effectiveness;empowerment;Exposure to;Feeds;Female;field study;fitness;Foundations;Future;Generations;Genotype;Glass;Goals;Hour;Human;Infection;inhibitor;innovation;Insecticide Resistance;Insecticides;Intervention;Laboratories;Lead;lead candidate;Leg;Libraries;Malaria;Malaria prevention;malaria transmission;Medicine;Methods;Modeling;Mole the mammal;Molecular Target;Multi-Drug Resistance;mutant;novel;Parasite resistance;Parasites;Persons;Pharmaceutical Preparations;Phenotype;Plasmodium;Plasmodium falciparum;Play;Population;Prevalence;prevent;Reproduction;Residual state;Resistance;resistance mechanism;resistant Plasmodium falciparum;Rest;Schools;screening;Stress;Surface;System;Testing;Therapeutic;tool;transmission blocking;transmission process;Treatment Failure;Tropical Medicine;uptake;Validation;vector;vector mosquito

PROJECT_TITLE: Malaria transmission blocking through mosquito contact with treated surfaces

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-S(02)M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dissemination and Implementation Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Primary Health Care

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Dementia is a long term, incurable condition characterized by progressive loss in cognition and function, with many patients receiving intensive medical interventions within the last year of life, despite it being unclear if these intensive measures of care actually benefit the patients’ quality of life or survival. Advance Care Planning (ACP) provides patients and their caregivers the opportunity to discuss their goals, values, and priorities for healthcare – particularly in the context of end-of-life care. This Mentored Career Development Award (K23) will launch my independent investigator career devoted to advance effective ways to improve ACP among community-dwelling cognitively impaired older adults.

PI_NAMEs: GABBARD, JENNIFER LYNN (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Adoption;Advance Care Planning;Affect;Alzheimer's disease related dementia;Award;care preference;career;Caregivers;Caring;catalyst;Clinical;Clinical Informatics;clinical practice;Cluster randomized trial;Cognition;cognitive interview;collaboratory;Communities;Community Healthcare;Coupled;Data Analyses;Data Collection;decision-making capacity;Dementia;design;disability;Disease;Documentation;Electronic Health Record;Electronics;Eligibility Determination;end of life;end of life care;Ensure;Environment;experience;feasibility testing;Funding;Goals;Health;Health Priorities;Healthcare;Healthcare Systems;high risk;Home;Impaired cognition;implementation barriers;implementation science;implementation strategy;improved;innovation;Intervention;Interview;K-Series Research Career Programs;Knowledge;Life;loved ones;Measures;Medical;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;mild cognitive impairment;mortality;Motivation;Nurses;older adult;Outcome;Outpatients;patient engagement;patient portal;Patients;Persons;pilot test;Population;primary care practice;primary care visit;Protocols documentation;Qualitative Methods;Qualitative Research;Quality of Care;Quality of life;Research;Research Design;Research Personnel;Research Proposals;Scientist;Site;Structure;Surveys;Symptom Burden;Technology;Telephone;Testing;tool;Training;translational physician;translational scientist;Translations;treatment as usual;Uncertainty;usability;user centered design;user-friendly;Visit;Work

PROJECT_TITLE: Implementation Strategies to Promote Advance Care Planning among Persons Living with ADRD and those with Mild Cognitive Impairment in Outpatient Primary Care Practices

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ORG_CITY: ATLANTA

ORG_DEPT: SURGERY

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative The overarching goal of this translational research project is to develop a new targeted cancer immunotherapy using a biocompatible and bioactive nanoparticle drug delivery system for the treatment of cancer patients with comorbid atherosclerosis or at a high risk of developing atherosclerosis. The proposed research project aims to develop a multifunctional immunomodulatory nanoparticle with the ability of targeted delivery into tumors and atherosclerotic plaques, inhibition of tumor cell growth, activation of anti-tumor immune responses and cytotoxic T cell function, and reduction of cholesterol-rich macrophages and effector T cells in atherosclerotic plaques. The effects of the targeted nanoparticle/drug on the inhibition of progression of metastatic colon cancer and atherosclerosis and the improvement of overall survival will be evaluated in mouse colon tumor models, dual mouse colon and atherosclerosis models, and human colon cancer patient derived xenograft models for feasibility of future clinical translation.

PI_NAMEs: YANG, LILY  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: activating transcription factor;Acyl Coenzyme A;Address;Adverse effects;Affect;anti-PD-L1 antibodies;anti-PD1 antibodies;anti-tumor immune response;Aorta;Apolipoprotein E;Area;Arterial Fatty Streak;Atherosclerosis;Binding;Binding Proteins;Biocompatible Materials;Biodistribution;Biological Process;biomaterial compatibility;biophysical properties;cancer immunotherapy;Cancer Model;Cancer Patient;cancer therapy;Cardiology;Cardiovascular Diseases;Cardiovascular system;Cause of Death;CD44 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;cell growth;Cell Physiology;Cell Proliferation;cell type;Cells;checkpoint therapy;chemotherapy;Cholesterol;Clinical;clinical development;clinical translation;Colon;colon cancer patients;Colon Carcinoma;Colonic Neoplasms;comorbidity;CT26;cytotoxic;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;design;Development;Disease;Dose;Drug Delivery Systems;Drug Kinetics;Drug Targeting;effector T cell;Encapsulated;Engineering;Future;Goals;High Fat Diet;high risk;Human;Hyaluronic Acid;Immune;immune activation;immune cell infiltrate;immune checkpoint;Immune response;Immunologics;Immunomodulators;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;Incidence;Infiltration;Inflammatory;Inflammatory Response;inhibitor;Investigation;irinotecan;Lesion;Macrophage;Malignant Neoplasms;MC38;metastatic colorectal;Microsatellite Instability;Modeling;mouse model;Mus;Nanoimmunotherapy;nanoparticle;nanoparticle delivery;nanoparticle drug;nanotherapeutic;neoantigens;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;Organ;Outcome;patient derived xenograft model;Patients;Peptides;Pharmaceutical Preparations;Phase I Clinical Trials;phase I trial;Play;pre-clinical;preclinical study;prevent;programmed cell death ligand 1;programmed cell death protein 1;Property;Proteins;Research;Research Project Grants;Resistance;response;Role;side effect;Signal Transduction;Solid Neoplasm;Sterol O-Acyltransferase;Symptoms;System;systemic toxicity;T-Lymphocyte;targeted delivery;targeted treatment;Therapeutic;Thrombosis;Tissues;Toxic effect;translational goal;Translations;Treatment Efficacy;treatment response;tumor;tumor growth;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;United States;Urokinase Plasminogen Activator Receptor;viscoelasticity;wound healing

PROJECT_TITLE: Development of multifunctional drug and immune modulator delivery nanoparticles for the treatment of cancer patients with comorbid atherosclerosis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative:  Sleep is essential for healthy brain function, and neurodegenerative diseases such as Alzheimer’s disease are associated with disrupted sleep. This project will use new imaging approaches to identify how neural activity, blood flow, and cerebrospinal fluid flow are jointly regulated in the brain during sleep and wakefulness. We will identify how sleep-dependent brain physiology changes in healthy aging and in individuals with genetic risk for Alzheimer’s disease, to advance our understanding of the biological mechanisms underlying the link between sleep and neurodegeneration.

PI_NAMEs: LEWIS, LAURA DIANE (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Age;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Auditory;Automobile Driving;Biological;Biological Markers;Blood;Blood flow;Blood Vessels;Blood Volume;Brain;brain based;brain health;cerebral blood volume;Cerebrospinal Fluid;cerebrospinal fluid flow;Cognition;cohort;Coupled;Coupling;Data;Development;Electroencephalography;Exhibits;fluid flow;Foundations;functional magnetic resonance imaging/electroencephalography;Future;Genetic Risk;genetic risk factor;Genotype;Health;healthy aging;Hearing Tests;hemodynamics;Human;Image;imaging approach;Individual;Intervention;Knowledge;life span;Link;Liquid substance;Measurement;Measures;Mediating;Memory;Multimodal Imaging;multimodality;Nerve Degeneration;neural;Neurodegenerative Disorders;Neurons;neurovascular coupling;non rapid eye movement;older adult;Onset of illness;Pathway interactions;Pattern;Physiology;potential biomarker;Process;protein aggregation;Proteins;response;Signal Transduction;Sleep;Sleep Deprivation;Sleep disturbances;sleep pattern;Slow-Wave Sleep;Stimulus;Symptoms;tau Proteins;Techniques;Testing;Time;Wakefulness;wasting;Work;young adult

PROJECT_TITLE: Sleep-dependent modulation of cerebrospinal fluid flow in aging

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative Deeply conserved human genes are strongly linked to diverse diseases, from cancer to neurodegeneration to cardiovascular disease. We propose to study these critical human genes by (1) using a comparative proteomics approach to biochemically define how the encoded proteins physically organize into multiprotein assemblies, which will help us better understand a variety of human genetic diseases, (2) systematically replacing yeast genes with their human equivalents, using the humanized yeast to directly experimentally measure the effects of human genetic variation and gene-drug interactions, and (3) advancing new proteomics technologies that would have broad applications across biology and medicine. Success of these efforts will provide new insights into basic human cell biology and biochemistry, laying the foundation for future attempts to intervene, chemically or genetically, with proteins critical to human cell health and disease.

PI_NAMEs: MARCOTTE, EDWARD M (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Amyotrophic Lateral Sclerosis;Antibodies;Area;Biochemical;Biochemistry;Biological;Biological Assay;Biology;biomarker discovery;Cardiovascular Diseases;Cell Physiology;Cells;Cellular biology;Chemicals;comparative;Congenital Abnormality;Defect;Disease;DNA biosynthesis;Drug Interactions;drug repurposing;Drug resistance;Electron Microscopy;Eukaryota;Foundations;Future;gene function;Genes;Genetic Diseases;Genetic Transcription;Genetic Variation;Health;high throughput screening;Human;human disease;Human Genetics;Human Genome;Huntington Disease;insight;large scale data;Link;macromolecule;Malignant Neoplasms;Mammalian Cell;Mass Spectrum Analysis;Measures;Medical;Medicine;Metabolic Diseases;Mitochondria;model organism;Molecular Machines;Nerve Degeneration;Parkinson Disease;Peptide Sequence Determination;protein complex;protein expression;Proteins;Proteome;Proteomics;Reagent;repaired;Research;RNA Splicing;Role;screening;Shotguns;single molecule;Structure of ciliary processes;success;Supporting Cell;Surveys;System;Techniques;Technology;trafficking;Work;Yeasts

PROJECT_TITLE: Proteomics and model organism humanization to decode human genetics

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Digestive Diseases;Food Allergies;Health Effects of Indoor Air Pollution;Nutrition;Prevention

ORG_CITY: NOTRE DAME

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project Narrative: Allergies are a major cause of illness in the US. Currently, there are no cures for allergies and the available therapies involve non-specific suppression of the immune system. The goal of this project is to establish a detailed understanding of IgE/allergen interactions in mast cell degranulation, and to engineer allergen specific molecules to inhibit allergic responses without non-specific suppression of the immune system.

PI_NAMEs: BILGICER, ZIHNI BASAR (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Absenteeism at work;Accidents;acute symptom;Address;Allergens;Allergic;Allergic Disease;Allergic Reaction;allergic response;Allergy to peanuts;alternative treatment;Anaphylaxis;Antibodies;Asthma;Binding;Cell Degranulation;Cell surface;Cessation of life;Chronic;Clinic;clinical application;Complex;design;Developed Countries;Development;Diet;dietary restriction;Drug Hypersensitivity;dust mite allergy;Effector Cell;Engineering;environmental allergen;environmental allergy;Epitopes;Evaluation;Event;Fishes;food allergen;Food Hypersensitivity;food restriction;Funding;Goals;Haptens;Hazelnuts;Health;Healthcare;Human;humanized mouse;Hypersensitivity;IgE;Immediate hypersensitivity;Immune response;Immune system;Immunodominant Epitopes;immunogenicity;Immunosuppression;In Vitro;in vivo;Individual;inhibiting antibody;inhibitor;innovation;Life;Liposomes;mast cell;Mediating;Metabolic;Methods;Molecular;mouse model;Names;next generation;novel;Patients;Penicillins;Pharmaceutical Preparations;Physiological;prevent;Preventive measure;Proteins;Pruritus;pyroglyphid;Reaction;Reproducibility;response;Risk;Sampling;Schools;screening;Severities;Shellfish;Shrimp;side effect;Signal Transduction;Specificity;Surface;System;Testing;translational potential;Validation;Work

PROJECT_TITLE: Designer covalent heterobivalent inhibitors to prevent IgE-dependent allergic reactions

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: One of the basic goals of doing research in health care is to make health better. This is done by moving the best research out of the lab, and bringing it to doctors so they can make care less expensive, more effective, or both. We generally call this process translational research, and years of experience has shown it can be very difficult. Fortunately, experts in translational research can teach the necessary skills so researchers can try to solve the many translational research problems earlier and faster. The VA-TEAM Center brings a team of experts, a series of online workshops, and a focused mentoring plan to the VA so we can change how the VA research community approaches the problems of translational research.

PI_NAMEs: BONOMO, ROBERT A.;CORNWELL, ANDREW ;KIRSCH, ROBERT F. (contact)

PROJECT_TERMS: Address;Area;Businesses;Capital;Caring;Clinical;clinical care;Collaborations;Communication;Communities;cost;Country;Critical Pathways;design;Disclosure;Ecosystem;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Effectiveness;experience;Funding;Funding Agency;Funding Mechanisms;Funding Opportunities;Future;Goals;Grant;Health;health care economics;Healthcare;improved;Industry Collaboration;Infrastructure;innovation;Intellectual Property;invention;Investments;Knowledge;knowledge translation;Learning;lectures;Licensing;Marketing;Measures;Medical Research;meetings;Mentors;Mission;Nature;Nuts;online course;Participant;Pathway interactions;Phase;pressure;Process;programs;Research;Research Personnel;Research Project Grants;Resources;Risk;Role;Series;Services;skills;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Students;symposium;teacher community;Technology;Technology Transfer;Testing;Training;Translating;Translation Process;Translational Research;translational scientist;United States Department of Veterans Affairs;United States National Institutes of Health;Veterans;Walking;Work;Writing

PROJECT_TITLE: Veterans Affairs - Translational Education and Mentoring (VA-TEAM) Center


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Alcohol is the 3rd leading cause of preventable death in the US, and binge drinking has an economic burden of $186 billion/year. Binge drinking is highly prevalent in active military duty personnel and veterans. More than 40% of military veterans have a lifetime history of alcohol use disorder (AUD). Thus, alcohol misuse exerts a large burden, especially within the VA. How individuals respond to their first experiences with alcohol is related to their risk for developing an AUD, including frequent early adult binge drinking (King et al., 2011; McCarty et al., 2004). Understanding the brain circuitry that underlies this dangerous pattern of drinking is an important first step in learning about vulnerability factors for AUD. We propose to identify brain regions engaged during binge drinking and manipulate specific brain circuits to determine what role they play in binge drinking. We will learn which circuits are engaged early, and this informs us of mechanisms that are involved in risk for AUD. If we can block them, then we are interfering with a mechanism important for risk for AUD.

PI_NAMEs: OZBURN, ANGELA RENEE (contact)

PROJECT_TERMS: Acute;Adult;Affective;Alcohol consumption;Alcohol dependence;alcohol misuse;alcohol risk;alcohol use disorder;Alcohols;Amygdaloid structure;Animal Model;Animals;antagonist;Behavior;Behavioral;binge drinking;Blood;Blood alcohol level measurement;Brain;brain circuitry;Brain region;Cell Nucleus;Cessation of life;Chronic;Consumption;Corticotropin-Releasing Hormone;Corticotropin-Releasing Hormone Receptors;cost;craving;Dangerousness;Darkness;Data;Deep Brain Stimulation;designer receptors exclusively activated by designer drugs;Diagnosis;directed attention;drinking;drinking water;Economic Burden;Economics;Ethanol;Ethanol dependence;Exhibits;experience;Female;FOS gene;Genetic;genetic manipulation;Genetic Models;Health;high risk;Hippocampus;Human;Human Resources;Immunohistochemistry;immunoreactivity;Individual;Insula of Reil;Intoxication;Learning;Literature;Maintenance;male;Medial;Mediating;Military Personnel;military veteran;Modeling;Mouse Strains;Mus;National Institute on Alcohol Abuse and Alcoholism;Nature;neural;Neurons;Neuropeptides;Neurotransmitters;Nucleus Accumbens;Pattern;Peptides;pharmacologic;Pharmacology;Play;preference;preventable death;Procedures;Recording of previous events;Relapse;Resistance;Risk;Role;Saccharin;sex;Signaling Molecule;social;Testing;Tracer;United States Department of Veterans Affairs;vapor;Ventral Tegmental Area;Veterans;Virus;Work

PROJECT_TITLE: Neural Substrates of Binge Drinking


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Complementary and Integrative Health;Neurosciences;Nutrition

ORG_CITY: WELLESLEY

ORG_DEPT: CHEMISTRY

ORG_NAME: WELLESLEY COLLEGE

ORG_STATE: MA

PHR: Project Narrative Purinergic signaling is a type of cell-to-cell communication that occurs in all organs. Extracellular ATP and ADP are important purinergic signals, but we lack methods to accurately measure them in biological samples. We are developing sensors to address this need, and they will be used to understand everything from brain function to our immune responses and pain.

PI_NAMEs: TANTAMA, MATHEW  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Acetoacetates;Acute;Address;Affect;Affinity;Astrocytes;autocrine;Biochemical;Biological;Biosensor;Blood Vessels;Brain;brain metabolism;brain tissue;Cell Communication;Cell Physiology;Cell surface;cell type;Cell Volumes;Cells;Chemotaxis;childhood epilepsy;Chronic;Coculture Techniques;Communication;Complex;Coupling;Cyclic AMP;design,build,test;Disease;Drug resistance;ecto-nucleotidase;effective therapy;Elements;Energy Metabolism;Ensure;Event;experimental study;extracellular;Fasting;Genetic Engineering;Goals;Health;Hydroxybutyrates;Hyperactivity;Image;imaging study;Immune;Immune response;In Vitro;Infection;Injury;insight;interest;ketogenic diet;Ketone Bodies;Kinetics;Knowledge;Learning;Length;Ligands;Lipids;live cell imaging;Long-Term Effects;Measurement;Measures;Mediating;Mediator;Metabolic;Metabolism;Methods;Microglia;Mitochondria;model organism;Molecular;Monitor;multiplexed imaging;nanomolar;neural network;Neuroglia;Neurons;neuroprotection;novel;Nucleotides;Optics;Organ;Organism;Pain;paracrine;Pathology;Pharmaceutical Preparations;Pharmacology;Phenotype;Physiological;Platelet Aggregation Inhibitors;Plavix;Preparation;Protein Engineering;Purinergic P1 Receptors;Purinoceptor;Receptor Activation;Regulation;Resolution;Sampling;Seizures;sensor;Sepsis;Series;Signal Transduction;small molecule;Specificity;Specimen;Stroke;Structure;success;Surface;Synaptic Transmission;System;Technology;Testing;Therapeutic;Tissues;tool;Traumatic Brain Injury;virtual;Visualization;Work

PROJECT_TITLE: Optical Tools to Study Purinergic Signaling

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Physical Injury - Accidents and Adverse Effects;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE We have developed a high-throughput biodosimetry device, the FAST-DOSE (Fluorescent Automated Screening Tool for Dosimetry) assay system to measure radiation-responsive proteins in human blood leukocytes for retrospective estimation of radiation dose. Studies are designed to validate and test the performance of the blood protein biomarker panel to accurately predict absorbed dose after ionizing radiation exposure. We will correlate biomarker expression levels and time kinetics with hematopoietic injury, based on peripheral blood leukocyte counts and bone marrow toxicity in humanized mice.

PI_NAMEs: TURNER, HELEN C (contact)

PROGRAM_OFFICER_NAME: VEDAMONY, MERRILINE M

PROJECT_TERMS: absorption;Academic Medical Centers;Acute;Age;Algorithms;Benchmarking;biodosimetry;Biological Assay;Biological Markers;biomarker identification;biomarker panel;biomarker performance;biomarker validation;Blood;Blood Proteins;Blood specimen;Bone Marrow;Bone Marrow Stem Cell;brca gene;Burn injury;Cell Culture Techniques;Cellular Structures;Color;Computer software;Confidence Intervals;Data;Data Analyses;data exploration;design;Detection;Development;Devices;Diagnostic Equipment;dirty bomb;disease-causing mutation;Dose;dosimetry;Exposure to;FDA approved;Flow Cytometry;Fluorescence;Future;Germ Lines;Hematology;Hematopoietic;Human;humanized mouse;Image;Imagery;Immune;Immunoassay;In Vitro;in vitro testing;in vivo;in-vitro diagnostics;Individual;Industrial Accidents;Inflammation;Inherited;Injury;ionization;Ionizing radiation;irradiation;Kinetics;Laboratories;Leukocytes;Linear Regressions;Lymphocyte;Machine Learning;machine learning algorithm;Mass Screening;mathematical model;Measures;Medical;Medical center;medical countermeasure;micronucleus;Modeling;Mus;Noise;nonhuman primate;nonlinear regression;Nuclear Accidents;Patients;Performance;performance tests;peripheral blood;Persons;Physiological;point of care;Population;predictive modeling;Process;protein biomarkers;Proteins;Protocols documentation;Radiation;Radiation Accidents;Radiation Dose Unit;Radiation exposure;Radiation Tolerance;Reproducibility;Research Design;response;response biomarker;Roentgen Rays;Saliva;Screening procedure;sex;stem;stem cells;Surface Antigens;System;Techniques;Testing;Time;Toxic effect;Trauma;Triage;Uncertainty;Urine;Variant;Vision;White Blood Cell Count procedure

PROJECT_TITLE: Development of FAST-DOSE assay system for the rapid assessment of acute radiation exposure, individual radiosensitivity and injury in victims for a large-scale radiological incident