ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

ORG_STATE: WI

PHR: Overall - Project Narrative The ability to produce blood cells is necessary throughout life, requiring hematopoietic developmental programs guided by cell-intrinsic and -extrinsic mechanisms conveying the need for these cells. The Program seeks to yield a transformative understanding of the role of glycosylation and glycans (cell surface sugars) in regulated blood cell production, in health and in disease. This knowledge will be leveraged to find novel therapeutic targets and therapeutics to promote hematopoietic health.

PI_NAMEs: HOFFMEISTER, KARIN MARIA (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Abnormal megakaryocyte;Accidents;Address;Affect;Affinity Chromatography;Automobile Driving;Blood;Blood Cell Count;Blood Cells;Blood Platelets;Bone Marrow;Burn injury;cDNA Library;Cell surface;Cells;Cellular Structures;Clinical;cofactor;comparative;Cues;Data;Development;Dimensions;Disease;Disease Progression;Dysmyelopoietic Syndromes;Dysplastic Megakaryocyte;Environment;extracellular;Functional disorder;Galactosyltransferases;Gene Expression;Generations;Glycobiology;Glycosaminoglycans;glycosylation;glycosyltransferase;Goals;Growth Factor;Health;Hematology;Hematopoiesis;Hematopoietic;hematopoietic stem cell fate;Hematopoietic stem cells;Heparan Sulfate Proteoglycan;Human;Iatrogenesis;Individual;insight;Integrins;Joints;Knowledge;Libraries;Life;Maintenance;Marrow;Mediating;Megakaryocytes;mimetics;Molecular;mouse model;Mus;Myelodysplastic/Myeloproliferative Disease;Myeloproliferative disease;new therapeutic target;novel;Platelet Count measurement;platelet function;Polysaccharides;Population;pre-clinical;Process;Production;programs;protein expression;Proteins;Proteomics;Publishing;Radio;receptor;Regulation;restoration;RNA;Role;Sampling;sialylation;Sialyltransferases;Signal Transduction;Source;Specimen;stem cell biology;stem cells;Stress;Structure;Structure-Activity Relationship;sugar;Sulfate;Therapeutic;Therapeutic Uses;Thrombocytopenia;Thrombopoiesis;Time

PROJECT_TITLE: Molecular and Clinical Glycobiology of the Bone Marrow Environment

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(OA)]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PROJECT_TERMS: Administrative Coordination;Advisory Committees;arm;Biology;Blood;Bone Marrow;Clinical;Clinical Data;Data;Databases;Environment;Glycobiology;Human;Leadership;meetings;Molecular;Myeloproliferative disease;New York;Participant;Periodicals;Persons;Polysaccharides;Principal Investigator;programs;Research;Research Institute;Roswell Park Cancer Institute;Sampling;Schedule;Scientist;Series;Site;Supervision;symposium;United States National Institutes of Health;Universities;video chat;Virginia;Wisconsin

PROJECT_TITLE: Core A: Administrative Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: NARRATIVE Our recent discoveries suggest that the ADAMTS9 metalloproteinase and cleavage of a novel substrate TMEM67 have major roles in kidney disease related to ciliopathies. ADAMTS9 and TMEM67 mutations result in the cystic kidney disease nephronophthisis (NPHP). We propose to investigate ADAMTS9- mediated TMEM67 cleavage as a novel disease mechanism crucial for normal kidney development and ciliogenesis.

PI_NAMEs: NANDADASA, SUMEDA  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: ADAMTS1 gene;Affect;Antibodies;Appearance;base;Brain;C-terminal;Cell Culture Techniques;cell type;Cells;Child;Cilia;ciliopathy;cilium biogenesis;Coiled-Coil Domain;conditional knockout;Corpus Callosum;CRISPR/Cas technology;Cysteine-Rich Domain;Cystic kidney;Cystic Kidney Diseases;Cytoplasmic Tail;Data;Development;Diagnosis;Disease;Disintegrins;Embryo;Endocytic Vesicle;Engineering;Epithelium;experimental study;extracellular;Extracellular Domain;Extracellular Matrix;Family;fluid flow;Homeostasis;Human;in vivo Model;insight;Integral Membrane Protein;Joubert syndrome;Kidney;kidney cell;Kidney Diseases;Knockout Mice;loss of function;Mammalian Cell;Mammals;mechanotransduction;Meckel-Gruber syndrome;Mediating;Membrane;Metalloproteases;Modeling;Mus;mutant;Mutation;N-terminal;nephrogenesis;Nephronophthisis;Notoencephalocele;novel;Null Lymphocytes;Organelles;overexpression;Pathology;Pathway interactions;Patients;Peptide Hydrolases;Play;Proteins;Proteolysis;Proteolytic Processing;Proteome;Proteomics;receptor;Recycling;Renal tubule structure;Reporting;Research;Role;segregation;Signal Transduction;Site;Structural Protein;Structure;Testing;Thrombospondins;Transgenic Mice;Tubular formation;Variant;Vesicle;Western Blotting;WNT Signaling Pathway

PROJECT_TITLE: Extracellular protease modulation of the cilium transition zone in kidney development and disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PI_NAMEs: WEILER, HARTMUT KARL-HEINZ (contact)

PROJECT_TERMS: analytical tool;Biochemical;Bioinformatics;Biological;Biological Models;Bone Marrow;cDNA Library;Cells;Clinical;cloud storage;Collaborations;Consult;Consultations;cost;Cryopreservation;Data;Data Analyses;Data Set;data sharing;Data Storage and Retrieval;data submission;Dedications;Environment;Enzymes;experimental study;Gene Expression;Gene Expression Profiling;Gene set enrichment analysis;Generations;genomic platform;Genomics;Glycobiology;Glycosaminoglycans;glycosylation;Goals;Hematopoietic;indexing;Laboratories;Laboratory Procedures;Libraries;Maintenance;Methods;Microfluidics;Modeling;Molecular;Polysaccharides;Population;Process;programs;Proteoglycan;Protocols documentation;public database;Qualifying;Quality Control;repository;Resources;response to injury;RNA;Sampling;Secure;single cell analysis;single-cell RNA sequencing;Site;Statistical Data Interpretation;Structure;Techniques;Tissue-Specific Gene Expression;Transcript;user-friendly

PROJECT_TITLE: Core B: Glyco-genomics and Bioinformatics


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: Veterans with Serious Mental Illness (SMI) struggle with social integration - participation in work, housing, and citizenship - due to symptoms, stigma, and psychosocial functioning deficits. This has a tremendous impact on mortality, comparable to that of smoking and greater than obesity and alcohol abuse. While the VA has made considerable efforts to provide mental health care to Veterans with SMI, programs that promote social integration are lacking. This project targets an especially vulnerable group, Veterans with SMI experiencing psychosis, with a peer support-based group approach. This virtual innovation is based on efforts from a consumer-driven, global social movement called the Hearing Voices approach. We seek to adapt and standardize this approach within the VA context via the development of a manual, training program for VA mental health clinicians and peers, and fidelity scale, which will then be piloted with 30 Veterans in 5 groups of 6 Veterans over the course of 20 weeks. This information will support the design of a controlled efficacy study.

PI_NAMEs: KALOFONOS, IPPOLYTOS ANDREAS (contact)

PROJECT_TERMS: acceptability and feasibility;Address;adverse outcome;Alcohol abuse;Belief;Caring;cohesion;Collaborations;Collection;Communities;Country;COVID-19 pandemic;Curiosities;Data;Dedications;Delusions;design;Development;Distress;Education;efficacy study;Employment;empowerment;Enrollment;experience;Feeling suicidal;follow up assessment;Fostering;Frequencies;Friendships;Future;Geography;Goals;Grant;Guidelines;Hallucinations;health related quality of life;Health Services;Health system;Hearing;high risk;Housing;Improve Access;improved;innovation;insight;internalized stigma;Intervention;Interview;Life;Link;Loneliness;Manuals;Marriage;Measurement;Measures;member;Mental Health;Mental Health Services;Meta-Analysis;Modeling;mortality;Netherlands;Obesity;Occupations;Outcome;outcome disparities;Outcome Measure;Participant;peer;peer support;Personal Satisfaction;Phase;pilot trial;Population;post intervention;Process;programs;Property;Protocols documentation;psychiatric symptom;Psychoses;psychosocial;Psychotic Disorders;psychotic symptoms;Public Health;Quality of life;Random Allocation;Recovery;recruit;remediation;Research;Running;Safety;Self Administration;Self Efficacy;service engagement;severe mental illness;Smoking;Social Functioning;social integration;Social isolation;social movement;social stigma;Specialist;Standardization;suicidal risk;Support Groups;Surveys;symposium;Symptoms;Target Populations;telehealth;Training;Training Programs;Transportation;Trust;Veterans;videoconference;virtual;virtual platform;Vision;Voice;Vulnerable Populations;whole health;Work

PROJECT_TITLE: Impact of Veteran Voices & Visions Peer Support Groups on Social Integration for Veterans with SMI/Psychosis

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Genetics;Kidney Disease

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative  Potential kidney cell replacement therapies require a sound knowledge of the developmental processes that build the nephron. Our proposed studies aim to understand how nephron endowment is determined by Hedgehog signaling in the mammalian kidney. The proposed research is relevant to public health because it will advance our capability to increase nephron endowment.

PI_NAMEs: PARK, JOO-SEOP  (contact)

PROJECT_TERMS: attenuation;Binding;Binding Sites;Cell Maintenance;cell replacement therapy;Cells;craniofacial development;Data;Development;Developmental Process;dosage;Dose;Endowment;Erinaceidae;FOXC1 gene;gain of function;Gene Expression Profile;Gene Expression Profiling;gene regulatory network;Genes;Genetic;genetic analysis;Genetic Enhancement;Genetic Transcription;genome-wide;Goals;high risk;Hypertension;improved;In Vitro;in vivo;insight;Kidney;kidney cell;kidney cortex;Kidney Diseases;Knowledge;LacZ Genes;Ligands;loss of function;Maintenance;Maps;Mediating;Mesenchymal;Mesenchymal Differentiation;Molecular;mutant;nephrogenesis;nephron progenitor;Nephrons;Neural tube;notch protein;Notch Signaling Pathway;novel;Organoids;pharmacologic;Play;Population;premature;Process;Proteins;Public Health;receptor function;Reporter;Reporting;Repression;Research;Role;self-renewal;Signal Pathway;Signal Transduction;smoothened signaling pathway;sound;stem cell population;stem cells;Testing;transcription factor;Up-Regulation

PROJECT_TITLE: Hedgehog gene regulatory networks in the mammalian kidney

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


PI_NAMEs: HAWKRIDGE, ADAM M (contact)

PROJECT_TERMS: Address;Affinity Chromatography;Area;Binding;Biological;Biological Process;Biology;biophysical properties;Bone Marrow;Bone Marrow Aspiration;Bone Marrow Cells;Capillary Electrophoresis;carbohydrate structure;Carbohydrates;cell growth regulation;Cells;chondroitin sulfate glycosaminoglycan;Chondroitin Sulfates;Clinical;Communities;comparative;Complement;Complex;Computer software;Confusion;Coupled;Data;Data Analyses;data repository;Data Set;Dedications;Disease;Environment;extracellular;Extracellular Protein;Foundations;Genetic;Genetic Transcription;Genome;Glycobiology;glycoproteomics;Glycosaminoglycans;Glypican;Goals;Hematopoietic stem cells;Hematopoietic System;Heparin;Heparitin Sulfate;innovation;insight;instrumentation;Label;Laboratories;Link;Liquid Chromatography;Mass Spectrum Analysis;Measures;Megakaryocytes;Membrane Proteins;Modification;Molecular;Mus;Names;Patients;Performance;perlecan;Polysaccharides;polysulfated glycosaminoglycan;Preparation;programs;Protein Analysis;protein expression;Proteins;Proteomics;Publishing;Research;RNA;Roentgen Rays;RPL29 gene;Sampling;secretory protein;serglycin;Serine;Spectrum Analysis;Stable Isotope Labeling;stem cell biology;Structural Models;Structure;syndecan;System;Techniques;Technology;technology platform;tool;Universities;Virginia

PROJECT_TITLE: Core C: GAGomics and Proteomics


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Patients on hemodialysis have high rates of hospitalizations. Yet, social determinants of health (economic instability, education, neighborhood and built environment, social and community context, and health and healthcare access), which have previously been demonstrated to be associated with hospitalization in hemodialysis patients, are not easily identified and used in research. We plan to identify these factors using prospective surveys and natural language processing software on electronic health records, where these factors are routinely documented, and add these factors to standard clinical factors in complex machine learning models to identify patients at higher risk for hospitalization, and in the process train Dr. Lili Chan into an independent clinical investigator in the field of “big data” research in nephrology.

PI_NAMEs: CHAN, LILI  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: adverse outcome;Advisory Committees;Affect;Age;Alcohol abuse;Algorithms;Appointment;Area;Award;Big Data;Bioinformatics;Biometry;Blood Vessels;built environment;career development;Caring;Categories;Centers for Disease Control and Prevention (U.S.);Chronic;Chronic Disease;Classification;Clinical;Clinical Investigator;Clinical Research;Coca;Code;cohort;Communities;Complex;Computer software;Computing Methodologies;Consumption;Data;Data Analyses;Data Element;Data Reporting;Data Set;data standards;Diagnosis;discrete data;Economics;Education;Electronic Health Record;electronic structure;End stage renal failure;Environment;experience;Faculty;Family;follow-up;Foundations;Funding;Future;Goals;Health;health care availability;health data;Health Personnel;Health system;Healthcare;Hemodialysis;high risk;high risk population;hospital readmission;Hospitalization;hospitalization rates;improved;individual patient;International Classification of Disease Codes;Intervention;Intervention Trial;K-Series Research Career Programs;Kidney;Kidney Diseases;Knowledge;Lead;Link;Literature;Machine Learning;machine learning method;machine learning model;Maintenance;Manuals;Maps;Medical;medical schools;Medicine;member;Mentors;Methodology;mid-career faculty;Modeling;Morbidity - disease rate;mortality;multidimensional data;multidisciplinary;Natural Language Processing;Neighborhoods;Nephrology;New York City;novel;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;Polypharmacy;poor health outcome;Population;Process;professor;prospective;Psychosocial Factor;Quality of life;Reference Standards;Research;Research Institute;Research Methodology;Research Personnel;Resources;Risk;Risk Factors;risk mitigation;risk prediction;risk prediction model;risk stratification;Self Care;Sensitivity and Specificity;Serum Albumin;social;social health determinants;social relationships;Social support;standard measure;Standardization;Statistical Methods;Substance abuse problem;Surveys;Symptoms;Techniques;Technology;Testing;Text;Time;tool;Training;transportation access;Treatment/Psychosocial Effects;validation studies;Work

PROJECT_TITLE: Improving risk prediction of adverse outcomes in hemodialysis patients by incorporating non-traditional risk factors

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Adults with traumatic brain injury (TBI) have persistent deficits in using and processing language in context, but commonly used methods to detect these deficits in clinical and research settings lack the required sensitivity and have focused on a limited subset of discourse tasks that do not reliably predict communication outcomes. Using ecologically valid language tasks and methods sensitive enough to detect even subtle, though meaningful, disruptions in language, the proposed work endeavors to show that deficits in contextual language processing in TBI extend even to the rapid processing of individual phrases and sentences in the moment (i.e., online processing), can be captured in controlled settings, and that such deficits are a predictor of communicative outcome. This proposal is unique in the field and uniquely promising for understanding the nature of deficits in contextual language processing following TBI and, ultimately, improving rehabilitation intervention outcomes.

PI_NAMEs: BROWN-SCHMIDT, SARAH ;DUFF, MELISSA C (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Adult;Affect;Aphasia;Automobile Driving;Basic Science;behavior measurement;Brain;Characteristics;Chronic;Clinic;Clinical;clinical care;clinical prognosis;clinical translation;Clinical Trials;Cognition;Cognitive;Communication;Communication impairment;community reintegration;Comprehension;Cues;Failure;flexibility;Foundations;Future;Goals;Heart;Impairment;improved;Individual;Intervention;Investigation;Knowledge;Language;language processing;Lead;Life;Linguistics;Link;Measures;Memory;Methods;Nature;Neuroanatomy;Neuropsychology;novel;novel strategies;Outcome;Participant;Patients;Performance;phrases;Physical environment;poor communities;Production;programs;Published Comment;Questionnaires;Recording of previous events;Rehabilitation therapy;Research;Secondary to;social;social communication;Social Environment;Stretching;Structure;Survivors;System;theories;Traumatic Brain Injury;visual tracking;Vocation;Work

PROJECT_TITLE: Language Processing in Context Following Traumatic Brain Injury

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The proposed research will inform guidelines needed to promote healthy gestational weight gain (GWG) in women with severe obesity, for whom current guidelines may be inappropriate. This study will use data from a unique populations of low-income mothers and children served by community health centers across the U.S. to investigate GWG patterns, specific to the degree of maternal obesity severity, that minimize risk of adverse birth outcomes, rapid infant growth, and childhood obesity in the offspring, and reduce racial and ethnic disparities in childhood obesity. The proposed research will (1) provide evidence needed to improve strategies for early prevention of obesity and (2) generate evidence aimed at alleviating the disproportionate burden of obesity in low-income and racial/ethnic minority women and children.

PI_NAMEs: BOONE-HEINONEN, JANNE ;SNOWDEN, JONATHAN M (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 5 year old;Academy;Address;adverse birth outcomes;Age;Birth;Birth Records;Birth Weight;Black race;Body mass index;Categories;Child;clinical practice;clinically significant;cohort;Data;data infrastructure;Development;Discipline of obstetrics;Disease;Disparity;disparity reduction;Electronic Health Record;Environment;ethnic disparity;ethnic diversity;ethnic minority;ethnic minority population;Ethnic Minority Women;Ethnic Origin;Family;Foundations;Future;General Population;Gestational Age;gestational weight gain;Goals;Growth;Guidelines;Health;Health Personnel;high risk;high risk population;Hispanic;improved;Inequity;Infant;Institute of Medicine (U.S.);Interdisciplinary Study;intergenerational;Intervention;Investigation;Knowledge;Life;Link;Low income;Low Income Population;lower income families;maternal obesity;Mediating;Mediation;Mediator;Medicine;Monitor;Morbid Obesity;Mothers;Neighborhood Health Center;Obesity;obesity in children;obesity prevention;obesity risk;offspring;Oregon;Outcome;Overweight;Patients;Pattern;Perinatal Epidemiology;Population;Pregnancy;Premature Birth;Prenatal care;prepregnancy;prepregnancy obesity;Prevalence;programs;prospective;Race;racial disparity;racial diversity;racial minority;racial minority population;racial minority women;Recommendation;Reduce health disparities;reproductive;Research;Research Personnel;Risk;risk minimization;Risk Reduction;safety net;Science;Severities;socioeconomic disparity;study population;Subgroup;Testing;Uninsured;Universities;Weight;Woman;Women's Group;Women's study

PROJECT_TITLE: PROMISE: PReventing Obesity through healthy Maternal gestational weight gain In the Safety nEt

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: PULLMAN

ORG_DEPT: CHEMISTRY

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative To adequately account for the role of stereochemistry and conformational variation in biological systems and their impact on health, new high resolution, high-throughput separation modalities are necessary. Our research program develops a new tandem ion mobility platform that integrates innovative electrode arrangements and drive electronics to prepare ions for laser dissociation at elevated pressures and provide new levels of analytical detail. With a focus on cost-effective and accessible solutions to enhance analytical performance, we envision broad adoption of this co-planar, traveling wave ion mobility system due to its ultra-high resolution capabilities and integrated fragmentation stages which directly address bioanalytical challenges across disciplines.

PI_NAMEs: CLOWERS, BRIAN  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;Adoption;Biological;biological systems;biophysical properties;Carbohydrates;Characteristics;Charge;Chemicals;Clinical;Communities;comparative;cost;cost effective;Cost Savings;Coupling;Data;data acquisition;density;Diagnostic;Diffusion;Dimensions;Discipline;Disease;Dissociation;electric field;Electrodes;Electronics;Evaluation;experience;experimental study;Foundations;Gases;Goals;Health;innovation;insight;instrumentation;Ion Channel;ion mobility;ionization;Ions;irradiation;Lasers;light emission;manufacture;mass analyzer;Mass Spectrum Analysis;Measurement;Measures;metabolomics;Minor;Modality;Modernization;Molecular;Molecular Conformation;molecular dynamics;molecular shape;Multidimensional NMR Techniques;Nature;Noise;Nucleic Acids;Outcome;Peptides;Performance;Phase;Photons;Population;pressure;printed circuit board;programs;promoter;Protein Conformation;protein folding;Proteins;Proteomics;prototype;Radial;Research;Research Personnel;Resolution;Role;Sampling;Series;Signal Transduction;Spectrometry;Speed;stereochemistry;structural biology;Structure;success;System;tandem mass spectrometry;Techniques;Technology;technology development;Time;tool;Transcend;transmission process;Travel;ultra high resolution;ultraviolet;Variant

PROJECT_TITLE: Tractable Tandem Ion Mobility Technology using Structures for Lossless Ion Manipulations and Photodissociation

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PROJECT_TERMS: Abnormal megakaryocyte;Affect;Alloimmunization;Blood Platelets;Bone Marrow;Bone Marrow Cells;Bone Marrow Transplantation;Cell surface;Cells;cellular targeting;chemoradiation;chemotherapy;Clinical;Cluster Analysis;comparison control;Data;Data Analyses;Defect;Development;Environment;extracellular;Fluorouracil;Galactosyltransferases;Gene Expression Profile;genetic signature;Glycobiology;Glycosaminoglycan Degradation Pathway;Glycosaminoglycans;glycosylation;Goals;Hematopoietic;Hematopoietic stem cells;Hemorrhage;Heparan Sulfate Proteoglycan;heparanase;Heparin Lyase;heparin proteoglycan;Heterogeneity;Human;Hyperactivity;Impairment;improved;In Vitro;in vivo;Injury;Integrins;Investigation;Joints;Knowledge;Libraries;Maintenance;Mediating;Megakaryocytes;Megakaryocytopoieses;Messenger RNA;Methods;mimetics;Molecular;Molecular Target;mouse model;mRNA Expression;Mus;Myelogenous;novel;Patients;Phenotype;Platelet Transfusion;Polysaccharides;Population;prevent;Production;programs;Proteins;Proteome;Reaction;Recovery;Risk;Role;Sialic Acids;sialylation;single cell genomics;single-cell RNA sequencing;Source;stem cell population;Stem cell transplant;Stress;Structure;Structure-Activity Relationship;Sulfate;Surface;Syndrome;Testing;Therapeutic;Thrombocytopenia;Thrombopoiesis;transcriptome;Transfusion;Virus Diseases;Work

PROJECT_TITLE: Project 1: Megakaryocytes as Organizers of the Hematopoietic Environment


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE By combining cutting-edge human imaging techniques with olfactory psychophysics approaches, “virtual reality” methods, and model-based analyses in healthy human subjects, the proposed research will generate new insights into the behavioral and neural substrates of odor navigation in the human brain. By addressing the “where” question of the human sense of smell, our work will uniquely extend the limited available data on how humans can use their noses to orient and path-find within an odorous landscape. Finally, insofar as deficits in the sense of smell often emerge as an early sign in Alzheimer’s disease, and which is often accompanied by visuospatial impairments and deficits of real-world navigation, the research findings obtained here may yield novel olfactory-based mechanistic frameworks for reorienting patients to their environment.

PI_NAMEs: GOTTFRIED, JAY A (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Address;Air;Alzheimer's Disease;Animals;Basic Science;Behavior;behavior test;Behavioral;Biological Assay;Birds;Brain;Categories;cell type;Cells;Characteristics;Code;Cognitive;Computing Methodologies;Cues;Data;design;Distal;Elements;Endowment;Ensure;entorhinal cortex;Environment;experimental study;flexibility;Floor;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Goals;high risk;Human;human imaging;human subject;Imaging Techniques;Impairment;information processing;Insecta;insight;interdisciplinary approach;Learning;Location;Mammals;Maps;Memory;Methods;Modeling;Movement;Nature;neural;Neurobiology;neuromechanism;Neurons;Neurosciences Research;Nose;novel;Odors;Olfactory Pathways;Oral cavity;Organism;Pathway interactions;patient oriented;Pattern;piriform cortex;Play;Poaceae;Positioning Attribute;Predisposition;Prefrontal Cortex;programs;Property;Psychophysics;receptor;Research;response;Rewards;Rodent;Role;Route;Sensory;sensory system;Sleep;Smell Perception;Source;Space Perception;stability testing;Stimulus;System;Techniques;Testing;Travel;two-dimensional;virtual;virtual reality;Visual;Visuospatial;Volatilization;way finding;Work

PROJECT_TITLE: Behavioral and Neural Substrates of Odor-Guided Navigation in the Human Brain

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Mental Health;Mental Illness;Rural Health;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Policies and interventions that seek to reduce the incarceration of individuals with serious mental illness and reduce the role of law enforcement in responding to mental health crises are of great importance to public health. To inform and facilitate evaluation of these policies and interventions, we will further the development of a large, existing, continually-updated county-wide dataset linked across 8 public agencies in Los Angeles County, which will (a) facilitate research that can identify and evaluate strategies for improving access, continuity, and equity of mental health services among some of the most vulnerable and potentially unserved individuals with serious mental illness and (b) facilitate ongoing monitoring of access, service continuity, equity, and outcomes such as incarceration and homelessness in diverse populations and settings. We will work with partners from Los Angeles County agencies and researchers from other geographic areas to develop approaches for identifying key information in the data—individuals with serious mental illness; key events such as mental health diversion services, alternative crisis services, arrests, and incarcerations; episodes of outpatient mental health services or homelessness; and service patterns before or after key events—and we will test the use of these linked data and approaches in an evaluation of alternative mental health crisis services in Los Angeles, in preparation for future research on policies and interventions that seek to reduce incarceration and law enforcement response to individuals with serious mental illness.

PI_NAMEs: CASTILLO, ENRICO GUANZON (contact);VON WACHTER, TILL

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: administrative database;Administrator;algorithm development;Algorithms;American;anti-racism;Area;Attention;Caring;Client;Communities;Consult;Consultations;County;Criminal Justice;Crisis Intervention;Data;Data Collection;Data Set;Databases;Development;Diversion Program;Economics;Electronic Health Record;Emergency response;Ensure;Equity;Evaluation;Event;experience;Failure;feasibility research;feasibility testing;Funding;Geographic Locations;Geography;Health;Health Services;Health system;Homelessness;Hospitalization;Human Rights;Imprisonment;Improve Access;improved;Individual;Institution;Intervention;Jail;Joints;Law Enforcement;Learning;Link;Local Government;Los Angeles;Measures;men;Mental disorders;Mental Health;Mental Health Services;Methods;Monitor;National Institute of Mental Health;Outcome;Outpatients;Pattern;people of color;Play;Police;Policies;Policy Analysis;Population;Population Heterogeneity;Poverty;Preparation;pressure;Prisoner;programs;Provider;Public Health;Public Sector;Race;Research;Research Personnel;Resources;response;Role;Rural;Sampling;Services;severe mental illness;Site;Social Work;Societies;Subgroup;System;Testing;Underserved Population;United States;Update;Validation;Vulnerable Populations;Work

PROJECT_TITLE: Serious mental illness and incarceration: piloting the use of a multi sector linked administrative dataset

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative  Autism spectrum disorder is characterized by impairments in the motivation to engage in social interactions. By using novel computational tracking system with a novel rodent model of social self- administration in rats with a mutation in the Shank3 gene (a rat model for ASD), in combination with cutting- edge tools and circuitry manipulation approaches, this proposal will determine the behavioral and neural mechanisms mediating the autism-like-induced shift in social motivation. This research will provide collaborative potential and introduce new ideas and a new conceptual framework to ASD research.

PI_NAMEs: VENNIRO, MARCO  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: addiction;Adoption;Amygdaloid structure;Animal Model;Animals;autism spectrum disorder;autistic children;awake;Behavior;Behavioral;Behavioral Mechanisms;Brain region;Classification;Complex;craving;Cues;Disease;Drug Interactions;drug relapse;Electrophysiology (science);Emotional;Ethology;Event;Future;Genes;genetic manipulation;Goals;graphical user interface;Human;Impairment;individuals with autism spectrum disorder;insight;interest;Intuition;Machine Learning;Medial;Mediating;model of autism spectrum disorder;Modeling;Motivation;Mutation;neural;neurobiological mechanism;neuroethology;neuromechanism;neuropsychiatric disorder;Neurosciences;novel;open source;optogenetics;Pharmaceutical Preparations;pharmacologic;pre-clinical;Pre-Clinical Model;preclinical study;prevent;Procedures;Punishment;Pythons;Rattus;Reciprocal Social Interaction;Reporting;Research;Rewards;Rodent;Rodent Model;Role;Self Administration;social;Social Behavior;social communication impairment;social deficits;social deprivation;social engagement;social factors;Social Interaction;social model;Stimulus;Study models;supervised learning;System;temporal measurement;Testing;Time;tool;unsupervised learning

PROJECT_TITLE: Behavioral and neural mechanisms mediating social motivation in a rat model for ASD

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: LAU, JOSEPH TY (contact)

PROJECT_TERMS: Affect;Attenuated;Automobile Driving;B-Lymphocytes;Blood Cells;Blood Platelets;Bone Marrow;Bone Marrow Diseases;Catalysis;Cell Maintenance;Cell surface;Cells;Characteristics;Clinical;clinical diagnostics;Collaborations;Cues;Data;Development;diagnostic strategy;Disease;Disparate;DNA Sequence Alteration;driver mutation;Dysmyelopoietic Syndromes;Dysplastic Megakaryocyte;Environment;extracellular;Extracellular Matrix;Generations;Genetic;Glycobiology;Glycosaminoglycans;glycosylation;glycosyltransferase;Health;Hematopoiesis;Hematopoietic;hematopoietic differentiation;Hematopoietic stem cells;Heterogeneity;Homeostasis;Interphase;Investigation;Lesion;Life;Ligands;Maintenance;Marrow;Mediating;Megakaryocytes;mimetics;Modality;Molecular;mouse model;Myelodysplastic/Myeloproliferative Disease;Myelogenous;Myeloid Cells;Myeloproliferative disease;Neoplasms;novel;novel diagnostics;novel therapeutics;Patients;Physiological;Platelet Count measurement;platelet function;Polysaccharides;Process;Production;programs;Regulation;Residencies;Role;Selectins;Sialic Acids;sialyl Lewis x;sialylation;Sialyltransferases;Signal Transduction;Source;Specificity;Syndrome;Testing;Therapeutic;therapeutic development;Time Study;transcriptomics;Work

PROJECT_TITLE: Project 2: Extracellular Glycosylation and Blood Cell Production


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Wnt growth factors controls many aspects of digestive system development, stem cell homeostasis and cancer, where it is an important therapeutic target. How Wnts control different genetic programs in different cells is an important unanswered question. We will test the novel idea that SOX proteins can influence which genes are activated in response to Wnt and elucidate the molecular mechanisms, which will have implications for controlling Wnt activity therapeutically.

PI_NAMEs: ZORN, AARON M (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: ATAC-seq;beta catenin;Binding;Binding Proteins;Binding Sites;Biochemical;Biological;Biological Assay;candidate identification;Cell Nucleus;cell type;Cells;ChIP-seq;Chromatin;cofactor;Complex;Computer Analysis;Consensus;Coupled;Cytoplasm;Data;Data Set;Development;Disease;DNA;DNA Binding;Embryo;Endoderm;Enhancers;Epigenetic Process;experimental study;gastrointestinal system;Gene Expression;gene repression;Genes;Genetic;genetic corepressor;Genetic Epistasis;Genetic Transcription;genome-wide;Genomic approach;Genomics;Growth Factor;Hindgut;Histones;HMG-Box Domains;Homeostasis;Human;human pluripotent stem cell;In Vitro;in vivo;Logic;Malignant Neoplasms;Mediating;Modeling;Molecular;Mutation Analysis;novel;Pathway interactions;Primitive foregut structure;progenitor;programs;Proteins;Publishing;Recombinants;recruit;Regulation;Reporter;Reporting;Repression;response;Role;Site;SOX17 gene;Specific qualifier value;Specificity;stem cell homeostasis;Systems Development;Testing;Therapeutic;therapeutic target;Tissues;transcription factor;transcriptome sequencing;WNT Signaling Pathway;Xenopus

PROJECT_TITLE: Sox Proteins Modulate Genomic Specificity of B-catenin Regulated Transcription in the Developing Gut

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

PHR: We propose a mixed methods study to evaluate the impact of VA-financed community care for Veterans with advanced kidney disease, and to identify subgroups within this population most likely to benefit and most likely to be harmed by receipt of nephrology care in the community. These patients comprise a high-cost high-needs segment of the Veteran population facing a critical health and care transition (onset of end-stage renal disease). The work we here propose is highly relevant to the VA mission (it will directly address three VA HSR&D priority areas), timely (the VA MISSION Act recently received strong bipartisan support in both the House and the Senate), and will directly inform evolving VA policy around the provision of community care for Veterans.

PI_NAMEs: O'HARE, ANN M. (contact)

PROJECT_TERMS: Address;Area;care coordination;care fragmentation;care providers;Caring;Characteristics;Clinical;Clinical Data;Communities;Community Financing;Community Healthcare;Continuity of Patient Care;cost;design;Dialysis procedure;early experience;Eligibility Determination;End stage renal failure;Evaluation;experience;Fees;Fistula;Health;health care availability;Health Promotion;Health Services Accessibility;Healthcare Systems;Hemodialysis;Heterogeneity;Hospitalization;improved;Incidence;Intervention;Interview;Kidney;Kidney Diseases;Kidney Transplantation;Learning;Maintenance;Managed Care;Measures;Medical;Medical center;Methods;military veteran;Mission;mortality;Nephrology;Outcome;Outpatients;Patient Care;patient population;Patient-Centered Care;Patients;Peritoneal Dialysis;Policies;poor health outcome;Population;Preparation;Process;process improvement;programs;Provider;Quality of Care;Readiness;Recording of previous events;Research Personnel;Resources;Shapes;shared decision making;Specialist;Structure;Subgroup;System;Transplantation;Variant;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Optimizing the value of community care for Veterans with advanced kidney disease

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Diabetes;Emerging Infectious Diseases;Infectious Diseases;Lung;Nutrition;Obesity;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

ORG_STATE: NJ

PHR: Project Narrative About one-third of the world's population is latently infected with tuberculosis (TB), and approximately 10% will at some point develop active disease. The proposed studies will examine the role of adipose tissue in the pathogenesis of pulmonary TB infection and explore the risk factors of Type 2 diabetes mellitus and HIV/AIDS involved in TB activation.

PI_NAMEs: NAGAJYOTHI, JYOTHI FALGUNI (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Ablation;Acute;Adipocytes;adipokines;adiponectin;Adipose tissue;Affect;Animal Model;Anti-Inflammatory Agents;Apoptotic;Body fat;Cells;Chronic;Clinical;Clinical Management;Communication;comorbidity;Data;Diet;Dietary Intervention;Disease;disease model;Disease Progression;Early Intervention;Fatty acid glycerol esters;Foamy Macrophage;Functional disorder;HIV;HIV/AIDS;Homeostasis;immune activation;Immune system;immunological status;In Vitro;Individual;Infection;innovation;Link;lipid biosynthesis;Lung;Mediating;Modeling;Molecular;Mus;Mycobacterium tuberculosis;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Pathogenesis;Pathology;Persons;Physiology;Population;Populations at Risk;Publishing;Pulmonary Pathology;Pulmonary Tuberculosis;Regulation;Research;Research Design;Risk;Risk Factors;Role;Severities;Signal Transduction;Testing;therapeutic target;Tuberculosis

PROJECT_TITLE: Immunometabolic regulations of pulmonary TB pathogenesis by adiposetissue

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: Princeton

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PRINCETON UNIVERSITY

PHR: Project Narrative Human Cytomegalovirus (HCMV) is a herpesvirus that remains a significant global health problem with no permanent effective therapy. The proposed study will investigate a potential relationship between HCMV and the host enzyme telomerase, a key regulator of a cell’s chromosomes and survival. Defining the importance of telomerase in the HCMV viral life cycle will enhance understanding of HCMV and similar herpesviruses, guide development of a permanent effective anti-viral therapy, and improve clinical management of HCMV.

PI_NAMEs: CAVANAUGH, CHLOE M (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acute;Aging;Anti-viral Agents;Anti-viral Therapy;Attenuated;attenuation;Binding;Biological Assay;Biology;burden of illness;Cell Line;Cell Survival;cell type;Cells;chromatin immunoprecipitation;Chromosomes;Chronic;Clinical;Clinical Management;clinically relevant;clinically significant;Congenital Abnormality;congenital infection;Cytomegalovirus;Cytomegalovirus Infections;Data;Developing Countries;Development;Disease;DNA;Dose;ds-DNA;Ectopic Expression;effective therapy;Enzymes;experimental study;Future;Ganciclovir;gene product;Genes;genetic inhibitor;global health;Goals;Herpesviridae;Human;Hyperactivity;Immediate-Early Genes;Immediate-Early Proteins;Immunocompetence;Immunocompetent;Immunocompromised Host;Impairment;improved;in utero;Individual;Infection;inhibitor;insight;knock-down;Laboratories;Latent virus infection phase;Life;Life Cycle Stages;Link;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Medical;Methods;Molecular;Mononuclear;Morbidity - disease rate;neonatal infection;novel therapeutics;Oncogenic;Pathogenicity;Pathway interactions;Pharmacologic Substance;Play;Population;Production;promoter;Proteins;Recrudescences;Repression;response;Risk;RNA-Directed DNA Polymerase;Role;Seroprevalences;small hairpin RNA;Small Interfering RNA;Stress;System;Telomerase;Telomerase inhibition;Telomerase Inhibitor;telomere;Testing;Tetanus Helper Peptide;Therapeutic;Transcript;Up-Regulation;Vaccines;Viral;Viral Genes;Viral Proteins;viral resistance;viral RNA;Virus;Virus Replication;Work

PROJECT_TITLE: Mechanism and Therapeutic Implication of Host Cell Telomerase Modulation by Human Cytomegalovirus


PI_NAMEs: DESAI, UMESH RAMANLAL (contact)

PROJECT_TITLE: Project 3: Role of Glycosaminoglycans in Hematopoiesis


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Pediatric

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT SUMMARY / RELEVANCE In this conference, researchers from around the world present and discuss the latest advancements in our understanding of how humans learn first and subsequent languages, whether typically developing or with language disorders. They also share, discuss, and debate methodological advances and the implications of current research for our understanding of how the brain functions and develops, and for identification and treatment of children with language disorders.

PI_NAMEs: CHANG, CHARLES B. (contact);HAGSTROM, PAUL ALAN;LIEBERMAN, AMY MICHELLE

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Area;Award;bilingualism;Boston;Brain;career;Child;Communities;Development;Disabled Persons;disabled students;Educational workshop;Ensure;ethnic minority;Exhibits;Fellowship;First Generation College Students;Fostering;Funding;Health;Human;interest;International;Language;Language Development;Language Disorders;Learning;literacy;meetings;Mentors;Methodology;Minority Groups;next generation;Oral;Peer Review;Postdoctoral Fellow;posters;programs;racial minority;Research;Research Personnel;Scholarship;Scientist;student conference;student participation;student training;Students;symposium;Training Activity;Travel;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: Boston University Conference on Language Development, 2022-2026

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Depression;Mental Health;Neurosciences;Rehabilitation

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Deep brain stimulation (DBS) has the potential to impact positively the lives of individuals with intractable depression. Converging lines of theoretical evidence have identified two fiber bundles in the subcallosal cingulate (SCC) as probable therapeutic targets of SCC DBS, and this study's goal is to test this connectomic hypothesis with computational rigor and electrophysiological validation using the latest computational framework for precision DBS. Rigorous computational standards and tools that can be disseminated to other groups working on SCC DBS can help simplify and objectivity the process of parameter selection in future clinical studies.

PI_NAMEs: MCINTYRE, CAMERON  (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Anatomy;bioelectricity;Biophysics;Chronic;Clinical;clinical center;Clinical Data;clinical decision support;Clinical Research;Clinical Trials;Complex;computer framework;computerized tools;connectome;Data;Data Set;Deep Brain Stimulation;density;design;Development;Devices;disability;electric field;Electrical Stimulation of the Brain;Electrodes;Electroencephalography;Electrophysiology (science);energy efficiency;Fiber;Forcep;Frequencies;Future;Goals;Head;improved;Individual;Industry;Judgment;Lead;Mental Depression;Minor;Modeling;Nature;Neuroanatomy;neuroimaging;next generation;novel strategies;Operative Surgical Procedures;Outcome;Pathway interactions;Patients;Physiologic pulse;Physiological;precision medicine;predictive modeling;Probability;Process;prospective;Protocols documentation;Research;Resistance;response;Scalp structure;sensor;simulation;Standardization;Stimulus;success;support tools;Technology;Testing;therapeutic target;Time;tool;Translating;treatment response;Validation;Width;Work;working group

PROJECT_TITLE: Pathway-Specific Targeting in Subcallosal Cingulate Deep Brain Stimulation for Depression

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Aging;Kidney Disease;Prevention

ORG_CITY: WASHINGTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: The proposed studies will test the hypothesis that mitochondrial dysfunction and increased inflammation mediates age-related kidney disease. We propose that a) increased expression of estrogen related receptors ERRα and ERRγ improves mitochondrial function, and decreases cGAS-STING signaling, cellular senescence and inflammation, which reverses age-related kidney disease; b) the effects of ERRs on senescence, inflammation, and fibrosis are cGAS-STING dependent; c) increased expression of ERRα and ERRγ or inhibition of cGAS-STING signaling prevents acute kidney injury mediated by folic acid, LPS, or ischemia/reperfusion

PI_NAMEs: LEVI, MOSHE  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;adeno-associated viral vector;age acceleration;age group;Age Months;age related;Age related comorbidities;age related decline;age-related disease;Aging;Agonist;Albumins;Bile Acids;Caloric Restriction;Cell Aging;Cells;Chronic Kidney Failure;cytokine;Disease;Elderly;estrogen-related receptor;Excretory function;Female;Fibrosis;Folic Acid;G-Protein-Coupled Receptors;Generations;GPBAR1 gene;Human;human old age (65+);Hypertension;Image;Impairment;improved;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury to Kidney;Ischemia;Kidney;Kidney Diseases;kidney fibrosis;Knockout Mice;Knowledge;Label;LoxP-flanked allele;male;Mediating;Metabolic syndrome;Microscope;microscopic imaging;Microscopy;Mitochondria;mitochondrial dysfunction;Modeling;Monitor;Mus;novel;Nuclear Hormone Receptors;old mice;Organ;Persons;Population;prevent;Prevention strategy;receptor;Recovery;Regulation;Renal function;Renal tubule structure;Reperfusion Therapy;response;Role;second harmonic;senescence;Signal Pathway;Signal Transduction;Stimulator of Interferon Genes;Testing;Three-Dimensional Imaging;TNF gene;Transforming Growth Factor beta;treatment strategy;Tubular formation;ultra high resolution;urinary

PROJECT_TITLE: Role of Estrogen Related Receptors in Age Related Kidney Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P(03)]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Human Genome;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

PHR: PROJECT NARRATIVE  MEHMO syndrome is a recently identified X-linked intellectual disability syndrome that presents with characteristic symptoms including: Mental deficiency, Epilepsy, Hypogenitalism, Microcephaly, and Obesity. MEHMO syndrome is caused by mutations in a core member of the cellular protein synthesis machinery; however, the causal links between mis-regulated protein synthesis and human disease remain poorly understood. The successful completion of the research proposed here will provide a thorough understanding of how protein synthesis is modulated in a global and gene-specific manner by a MEHMO syndrome mutation, and identify key factors contributing to the MEHMO syndrome phenotypes that could significantly aid in the development of therapeutics and improved strategies for patient treatment.

PI_NAMEs: YOUNG-BAIRD, SARA KATHRYN (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: acronyms;Address;Affect;Automobile Driving;Award;biological adaptation to stress;Biological Assay;Biology;Candidate Disease Gene;career;Cell Line;Characteristics;CRISPR/Cas technology;Development;Diagnosis;Disease;disease-causing mutation;early childhood;effective therapy;Electrophysiology (science);Epilepsy;excitatory neuron;Exhibits;experience;experimental study;Gene Expression;Generations;Genes;genome editing;genome-wide;Goals;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate;homologous recombination;human disease;Immunohistochemistry;Impairment;improved;induced pluripotent stem cell;Informatics;Initiator Codon;Knowledge;Link;Measurement;MEHMO syndrome;member;Mental deficiency;Messenger RNA;Microcephaly;Molecular;Molecular Analysis;mRNA Translation;multidisciplinary;mutant;Mutation;Neurons;Obesity;Outcome;Pathogenesis;patient derived induced pluripotent stem cells;Patients;Peptide Initiation Factors;Phenotype;Play;polysome profiling;Positioning Attribute;postsynaptic;presynaptic;Prokaryotic Initiation Factor-2;Protein Biosynthesis;protein function;Quantitative Reverse Transcriptase PCR;Research;ribosome profiling;Role;Site;Stains;Symptoms;Syndrome;Techniques;therapeutic development;translation factor;Translation Initiation;Translational Regulation;Translations;treatment strategy;Validation;Western Blotting;white matter;White Matter Disease;X-linked intellectual disability

PROJECT_TITLE: Molecular analysis of MEHMO syndrome mutations in translation factor eIF2

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Nutrition;Prevention;Sleep Research

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE This proposal is aimed at defining how disruption of the circadian clock, both genetic and environmental, accelerates colorectal cancer pathogenesis using mouse models and patient-derived intestinal organoids. We propose that the circadian clock regulates signaling and proliferation pathways as well as rewired metabolism to drive transformation of the intestinal epithelium. Our molecular studies will provide new insight towards prevention strategies and targeted therapeutic approaches for the treatment of colorectal cancer that rely on pharmacological modulation of the circadian clock.

PI_NAMEs: MASRI, SELMA  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Acceleration;Address;Adult;Age;APC mutation;ARNTL gene;Behavioral;biobank;Biological Assay;Biological Models;c-myc Genes;cancer diagnosis;cancer prevention;cancer type;cell growth regulation;Cell Proliferation;Cells;circadian;Circadian Dysregulation;Circadian gene expression;circadian pacemaker;circadian regulation;Circadian Rhythms;Clinical;Clinical Data;Code;colon cancer patients;Colorectal Cancer;colorectal cancer prevention;colorectal cancer treatment;Colorectal Neoplasms;Complex;Computer Analysis;Coupled;Data;Death Rate;Development;Diagnostic Neoplasm Staging;Diet;dietary;dietary control;Dietary Factors;DNA Damage;Down-Regulation;driver mutation;early onset;early onset colorectal cancer;Eating;Environmental Risk Factor;Enzymes;Epithelial Cells;exome sequencing;experimental study;feeding;Genes;Genetic;Genome;Genome Stability;Genomic Instability;Goals;High Fat Diet;Hormonal;Human;human data;Incidence;insight;interdisciplinary approach;intestinal epithelium;Intestinal Polyps;Intestines;knock-down;lifestyle factors;Link;Loss of Heterozygosity;Malignant Neoplasms;Maps;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;metaplastic cell transformation;Modeling;Molecular;mouse model;Mus;Mutation;novel;nutrition;older patient;Oncogenic;Organoids;Pacemakers;Pathogenesis;Pathway interactions;Patients;Periodicity;Peroxisome Proliferator-Activated Receptors;Pharmaceutical Preparations;pharmacologic;Polyps;Prevention strategy;Proliferating;reconstitution;Reporting;Research;response;Risk Factors;Role;Sampling;Signal Transduction;Sleep Wake Cycle;stable isotope;stemness;Stress;Surveys;Survival Rate;System;targeted treatment;Testing;The Cancer Genome Atlas;therapy development;Time-restricted feeding;TP53 gene;transcription factor;transcriptome;Tumor Suppressor Proteins;tumorigenesis;United States;WNT Signaling Pathway;young adult

PROJECT_TITLE: Circadian Clock and Myc-dependent Regulation of Cellular Transformation

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative The Alzheimer's disease (AD) is a progressive neurodegenerative disease, and the age is a major factor for the most case of AD, but the mechanisms underlying the link between age and AD is still unclear. In this project we will use mouse models and human postmortem tissue to examine a novel epigenetic mechanism that effects on aging and AD, and whether changes of epigenetic regulation in aging could steer normal aging toward AD development. The information derived from the project will help to develop new prevention and treatment strategies that benefit AD patients.

PI_NAMEs: DONG, HONGXIN  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Acceleration;Adult;Affect;Age;Age Months;Age Years;aged;Aging;aging population;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's neuropathogenesis;Amyloid;Animal Model;APP-PS1;Autopsy;Behavior;Biological Assay;Biological Markers;Brain;brain tissue;chromatin immunoprecipitation;Cleavage Under Targets and Release Using Nuclease;CRISPR/Cas technology;Development;Diagnosis;Disease;DNA Methylation;Dose;drug action;Elderly;Elements;Environment;Epigenetic Process;epigenetic regulation;epigenome;Functional disorder;Gene Expression;Gene Expression Regulation;Gene Modified;Genes;Genetic;genetic approach;Genetic Transcription;genome-wide;Glutamate Receptor;Hippocampus;Histone Acetylation;histone deacetylase 2;histone methylation;histone modification;Histones;Human;human old age (65+);improved;inhibitor;knock-down;Life;Link;Maps;Mediating;Memory;Memory impairment;Memory Loss;Molecular;Molecular Target;mouse model;MS-275;Mus;Neurodegenerative Disorders;Neuronal Plasticity;Neurons;neuropathology;new therapeutic target;normal aging;novel;novel therapeutic intervention;overexpression;Pathogenesis;Pathway Analysis;Pharmacological Treatment;Play;Prefrontal Cortex;prevent;Prevention;Prevention strategy;pro-aging;promoter;Promoter Regions;protein expression;Research;response;Risk;Risk Factors;Role;Stimulus;synaptic function;Synaptic plasticity;Testing;Therapeutic;Tissues;tool;transcriptome sequencing;treatment strategy;Twin Studies;Wild Type Mouse;Work

PROJECT_TITLE: Epigenetic Regulation in Aging and Alzheimer's Disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Word finding difficulty (verbal retrieval deficit) is one major language sequela of traumatic brain injury (TBI), with effective treatment still lacking. The pre-Supplementary Motor Area (pre-SMA) has an important role in verbal retrieval and may be modulated by high-definition transcranial direct current stimulation (HD-tDCS) to remediate verbal retrieval deficits. The proposed study will use HD-tDCS to modulate the pre-SMA in order to treat TBI-related verbal retrieval deficits, and the overall aims are to 1) examine underlying mechanisms based on synchronized neuronal activity measured by electroencephalography (EEG), 2) examine how white matter integrity of two pre-SMA associated tracts important for verbal retrieval affects HD-tDCS induced improvement, and 3) develop predictive models based on mechanisms that will guide selection of better responders for HD- tDCS intervention.

PI_NAMEs: CHIANG, HSUEH-SHENG  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Advanced Development;Affect;Aftercare;aging population;Algorithms;American;Anatomy;Area;Award;axon injury;Basal Ganglia;Biological Markers;Brain region;career;career development;Chronic;Classification;clinical application;Cognitive;cognitive control;Cognitive deficits;cognitive function;cohort;Color;Communication impairment;Corpus striatum structure;Data;demographics;Detection;Diagnosis;Diffusion Magnetic Resonance Imaging;Disease;effective therapy;Electroencephalography;Electrophysiology (science);Financial Hardship;Foundations;Functional disorder;Funding;Future;Goals;Impairment;improved;Individual;individual variation;Inferior frontal gyrus;Injury;Intervention;K-Series Research Career Programs;Language;language impairment;Lead;Left;Link;Measures;middle age;Modeling;Motor;multimodality;National Institute on Deafness and Other Communication Disorders;neural circuit;neurological rehabilitation;neuromechanism;Neurons;Neuropsychology;noninvasive brain stimulation;novel;novel strategies;Outcome;outcome prediction;Pathway interactions;Performance;Phase;Pilot Projects;Population;Precision therapeutics;predicting response;predictive modeling;programs;Recording of previous events;remediation;Research;Research Project Grants;responders and non-responders;Retrieval;Role;Secondary to;semantic processing;Site;skills;Speech;Strategic Planning;Survivors;TBI treatment;Therapeutic;Therapeutic Effect;Training;transcranial direct current stimulation;Traumatic Brain Injury;Treatment Protocols;treatment response;United States National Institutes of Health;Validation;verbal;Veterans;Voice;white matter;Work

PROJECT_TITLE: Using High Definition transcranial Direct Current Stimulation Guided by Electrophysiology and Diffusion Tensor Imaging to Treat Verbal Retrieval Deficits Secondary to Chronic Traumatic Brain Injury

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: PROJECT NARRATIVE  The cochlea is the part of the inner ear that responds to sounds and is the primary organ for our sense of hearing. The proposed research program will develop a computational simulation of cochlear mechanics that addresses a fundamental question regarding amplification in the cochlea. In addition, results from cochlear models will be combined with physiological and behavioral data from human subjects to support the investigation of specific auditory phenomena, such as acoustic reflections from the cochlea, speech-consonant perception, and multi-tone loudness growth. Thus, the proposed research combines human measurements and computer simulations to address important questions about hearing processes that have both basic scientific and applied clinical relevance.

PI_NAMEs: NEELY, STEPHEN T (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acoustic Nerve;Acoustics;Address;Affect;Amplifiers;Area;Auditory;Auditory system;Auditory Threshold;Basilar Membrane;behavior measurement;Behavioral;Clinical;clinically relevant;Cochlea;Complex;Computer Models;Computer Simulation;Confusion;Dependence;Development;Diagnosis;Dimensions;Elements;Exhibits;Frequencies;Functional disorder;Goals;Growth;Hearing;Hearing Aids;hearing impairment;Human;human data;human model;human subject;Impairment;improved;Inner Hair Cells;innovation;interest;Investigation;Knowledge;Labyrinth;Liquid substance;Loudness;Measurement;mechanical properties;Mechanics;method development;Methods;middle ear;Modeling;Motion;neural;Noise;Non-linear Models;novel;Organ;otoacoustic emission;Outer Hair Cells;Pattern;Perception;Peripheral;Physiological;pressure;Process;programs;Property;Recording of previous events;remediation;Research;Residual state;Role;satisfaction;Sensorineural Hearing Loss;signal processing;Signal Transduction;simulation;sound;Speech;Statistical Data Interpretation;Stimulus;Testing;theories;transmission process

PROJECT_TITLE: COCHLEAR MECHANICS, WAVE PROPAGATION, AND COMPRESSION

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Cancer;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE The proposed research is an innovative approach to an unmet need in the treatment of hematological malignancies: the inability to target malignant stem cells, the source of relapse and disease progression. We discovered a new druggable target molecule that can specifically reduce the number of malignant stem cells in primary myelofibrosis caused by the JAK2V617F mutation. If successful, this application will address the urgent need to develop treatments that specifically target JAK2V617F stem cells to produce better long-term outcomes than current therapies.

PI_NAMEs: MATSUURA, SHINOBU  (contact)

PROGRAM_OFFICER_NAME: VONKOLLMAR, DESIREE

PROJECT_TERMS: Actins;Acute Myelocytic Leukemia;Address;Adult;Animals;Antibodies;ANXA5 gene;Apoptosis;Applications Grants;Blood;Blood Cells;Bone Marrow;cancer stem cell;cancer therapy;career;Caspase;CD29 Antigen;Cell Adhesion Molecules;Cell Cycle;Cell Death;Cell Death Induction;Cell Differentiation Induction;Cell Maintenance;Cells;Cytoskeleton;Data;Development;Disease;Disease Progression;Disease remission;driver mutation;Environment;experimental study;extracellular;Flow Cytometry;Goals;Hematologic Neoplasms;Hematopoietic;Hematopoietic stem cells;Human;improved;in vivo;Induction of Apoptosis;inhibitor;innovation;Integrin Inhibition;Integrin-mediated Cell Adhesion Pathway;Integrins;intraperitoneal;Intravenous;JAK2 gene;Laboratories;Leukemic Cell;leukemic stem cell;Maintenance;Measures;Mediator;Megakaryocyte Proliferation;Megakaryocytes;Mentored Research Scientist Development Award;Molecular Target;mouse model;Mus;Mutation;Myelofibrosis;Myeloproliferative disease;new therapeutic target;Organism;Outcome;Patients;Persons;Predisposition;Primary Myelofibrosis;Production;Proliferating;Publications;Relapse;Reporting;Research;Role;Signal Transduction;Source;Splenomegaly;Stem Cell Mobilization;stem cells;success;Symptoms;Therapeutic;therapeutic development;tositumomab;Transgenic Mice;United States;Work

PROJECT_TITLE: Targeting beta1 integrin in JAK2V617F+ stem cells


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Clinical Research;Emergency Care;Health Services;Immunotherapy

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE Immune related adverse events from immune checkpoint inhibitors (ICPIs) are particularly challenging in the Emergency Department (ED) because of atypical presentations, the absence of classic symptoms, delayed availability of diagnostic tests during the ED encounter, and the fast pace in the ED setting. This patient-cen- tered project aims to develop and prospectively validate a probability model [Immune-related Emergency Dis- position index (irEDi)] that integrates immune/inflammation markers that are readily available in the ED with demographic, biological, cancer, treatment, and clinical data at the ED to guide ED disposition (Hospital admis- sion; observation; or discharge) in a multi-center cohort study of ED patients on ICPIs.

PI_NAMEs: REYES-GIBBY, CIELITO C (contact);YEUNG, SAI-CHING JIM

PROGRAM_OFFICER_NAME: SHELBURNE, NONNIEKAYE F

PROJECT_TERMS: Accident and Emergency department;Admission activity;Age;Autoimmune Diseases;Binding Sites;Biological;Biological Factors;Biometry;Blood Platelets;Body mass index;C-reactive protein;California;Cancer Center;Cancer Patient;cancer therapy;Caring;Chronic;Clinical;Clinical Data;Cohort Studies;Colitis;Collaborations;comorbidity;Comprehensive Cancer Center;Computer software;Data;Data Collection;Data Sources;Decision Making;Development;Diagnosis;Diagnostic;Diagnostic tests;Dose;Electronic Health Record;Emergency Care;Emergency Department patient;Emergency department visit;Emergency Medicine;Emergency research;emergency settings;Emergency Situation;Epidemiologic Factors;Epidemiology;Erythrocyte Sedimentation Rate;ethnic difference;Ethnic Origin;follow-up;Future;Geography;Glucocorticoids;Goals;Guidelines;Hospitalization;Hour;Image;imaging study;Immune;Immune checkpoint inhibitor;Immune response;immune-related adverse events;Immunologic Markers;Immunooncology;improved;indexing;Inflammation;inflammatory marker;innovation;Institution;interest;Laboratories;Length of Stay;Life;Lymphocyte;Malignant Neoplasms;Morbidity - disease rate;mortality;multidisciplinary;Neoplasm Metastasis;neutrophil;Ohio;Outcome;palliating symptoms;Patient Discharge;patient oriented;patient stratification;Patients;Population Heterogeneity;predictive marker;predictive tools;Process;prospective;Prospective, cohort study;Publishing;Pulmonary Inflammation;Race;racial difference;Recommendation;recruit;Research;Resources;risk stratification;Sampling;Severities;sex;sex as a biological variable;Site;Specificity;Standardization;Statistical Models;Symptoms;Telephone;tool;Universities;Visit

PROJECT_TITLE: Improving emergency care and outcomes of immune-related adverse events: The immune-related emergency disposition index (IrEDi)

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Schizotypal personality disorder (SPD) is similar to schizophrenia (SZ), but with fewer and attenuated abnormalities, representing an important yet understudied intermediate SZ-spectrum phenotype that provides important information regarding etiology, genetics, treatment and risk factors associated with psychosis. This study utilizes a Research Domain Criteria (RDoC) approach coupled with longitudinal multimodal MR imaging and neurocognitive assessment in SZ-spectrum disorders to identify aberrant neural circuitry and cognition along a continuum from healthy controls to SPD (in the SZ spectrum but not fully psychotic) to SZ (psychosis). Changes in frontal-temporal regions/circuitry and neurocognitive measures over time will be examined together using novel approaches (e.g., machine learning) to predict diagnostic group, symptom severity, and functional outcome for the identification of key factors associated with risk and resilience in the SZ spectrum.

PI_NAMEs: HAZLETT, ERIN A. (contact);SZESZKO, PHILIP R

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Age;Antipsychotic Agents;Attenuated;Brain;Brain region;Brodmann's area;causal model;Clinical;Clinical assessments;Cognition;Cognitive deficits;Coupled;Data;Deterioration;Diagnosis;Diagnostic;Diffusion Magnetic Resonance Imaging;Disease;early onset;Etiology;Event;follow-up;frontal lobe;Functional Magnetic Resonance Imaging;functional outcomes;Genetic;Goals;Hospitalization;Impairment;improved;Individual;Investigation;Link;longitudinal course;longitudinal design;Longitudinal Studies;Machine Learning;Magnetic Resonance Imaging;Measures;Modeling;morphogens;multimodal neuroimaging;multimodality;neural circuit;Neurobiology;Neurocognition;Neurocognitive;neuroimaging;Neuropsychology;non-verbal;novel strategies;Onset of illness;Outcome;Pathogenesis;Patients;Pattern;Performance;Personality Disorders;Pharmaceutical Preparations;Phenotype;predictive modeling;Prefrontal Cortex;protective factors;Psychoses;psychotic;Research Domain Criteria;resilience;Rest;Risk;Risk Assessment;Risk Factors;Scanning;Schizophrenia;schizophrenia spectrum disorder;Schizotypal Personality Disorder;Severities;Short-Term Memory;social deficits;Structure;Symptoms;Temporal Lobe;Testing;Time;Treatment Factor;white matter

PROJECT_TITLE: Longitudinal neuroimaging and neurocognitive assessment of risk and protective factors across the schizophrenia spectrum

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research aims to determine the functional connectivity and behavioral roles of subcortical-to- hippocampal CA3 projections, including the basolateral amygdala-to-CA3 and supramammillary nucleus-to- CA3 inputs. Given the strong involvement of CA3 in a range of neurological and psychiatric disorders, such as posttraumatic stress disorders (PTSD), depression, chronic stress, and epilepsy, the knowledge gained from this proposal will provide novel insights into its normal functions and provide a foundation for future studies to explore the role of these pathways in mental disorders.

PI_NAMEs: SUN, QIAN  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Amygdaloid structure;Area;Behavioral;Brain;Cannulas;Cell Nucleus;Chronic stress;Clozapine;dentate gyrus;Dependovirus;designer receptors exclusively activated by designer drugs;Disease;Distal;entorhinal cortex;Epilepsy;experimental study;fear memory;FOS gene;Foundations;Fright;Functional disorder;Future;genetic approach;Genetic Suppression;granule cell;Heterogeneity;hippocampal pyramidal neuron;Hippocampus;Hypothalamic structure;Immunohistochemistry;Impairment;Implant;in vitro activity;in vivo;information processing;Injections;insight;Interneurons;Knowledge;knowledge base;Learning;Link;Mediating;Memory;Mental Depression;Mental disorders;mossy fiber;neglect;Nervous System Disorder;neural circuit;Neurons;neuropsychiatric disorder;novel;Output;Oxides;patch clamp;Pathway interactions;Perforant Pathway;Population;Post-Traumatic Stress Disorders;Rabies virus;Recurrence;Research;Role;Satellite Viruses;Schizophrenia;Synaptic Transmission;Testing;Viral;way finding

PROJECT_TITLE: The role of subcortical inputs to the hippocampal CA3 region in fear memory

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: NS

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Human Genome;Neurosciences;Sleep Research

ORG_DEPT: GENETICS

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative The pressing need to understand sleep is underscored by the major clinical and economic impact of sleep disorders: 10-15% of the U.S. population suffers from chronic insomnia, and nearly one hundred sleep disorders have been described, including narcolepsy, sleep apnea, and delayed and advanced sleep phase syndromes. Molecular genetic studies that began in Drosophila have already allowed mutant orthologs of Period proteins, casein kinase 1, and Cryptochromes to be connected to inborn errors of human sleep. We believe our proposed genetic, cellular, and biochemical studies of Drosophila will continue to provide insights and tools relevant to the understanding of human sleep, and will complement our deepening, direct investigations of human sleep genetics.

PI_NAMEs: YOUNG, MICHAEL WARREN (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Advanced Sleep Phase Syndrome;Affect;Age;aged;Aging;Alleles;Anxiety Disorders;Area;awake;Behavior;behavioral phenotyping;behavioral study;Biochemical;Biological;Biological Assay;biophysical properties;Blood - brain barrier anatomy;blood-brain barrier function;blood-brain barrier permeabilization;candidate identification;candidate selection;casein kinase I;Cell Culture Techniques;Cell Physiology;Chronic Disease;Chronic Insomnia;circadian;circadian pacemaker;Circadian Rhythms;Clinical;clinically significant;comorbidity;comparative;Complement;cryptochrome;Cullin Proteins;Databases;Diabetes Mellitus;Disease;Drosophila genus;economic impact;Etiology;exome;fly;Gene Expression;Gene Frequency;gene function;Genes;Genetic;Genetic Polymorphism;Genetic Screening;Genetic study;Genetic Variation;genome-wide;Hereditary Disease;Heritability;Human;human error;human subject;improved;Individual;insight;Interdisciplinary Study;Investigation;kindred;life span;Link;Longevity;Meleagris gallopavo;Molecular;Molecular Genetics;molecular sequence database;Mood Disorders;Morphology;mutant;Mutation;Narcolepsy;Neuroglia;novel strategies;Obesity;Orthologous Gene;Pathway interactions;Pattern;Periodicity;Permeability;Phase;Phenotype;Physiological;Population;prediction algorithm;preservation;Proteins;Recovery;Regulation;Research;response;RNA Interference;Role;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep Disorders;sleep pattern;Sleep Wake Cycle;Testing;tool;transcriptome sequencing;Universities;Variant

PROJECT_TITLE: Interdisciplinary Studies of Sleep and Circadian Rhythms


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: Project Narrative A diverse range of biological phenomena requires the precise and coordinated control of gene expression. We recently identified NDF, an evolutionarily conserved, novel RNA Polymerase II (Pol II) transcription factor. In this project, we will address molecular mechanisms of NDF- mediated Pol II transcription, which will increase the breadth and depth of our understanding of the regulation of eukaryotic transcription through chromatin.

PI_NAMEs: FEI, JIA  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;Affinity Chromatography;Area;Biochemical;Biochemistry;Bioinformatics;Biological Assay;Biological Phenomena;biophysical techniques;cell fate specification;Cell Nucleus;Cell Physiology;Cell Survival;Cells;Chromatin;Collaborations;CRISPR/Cas technology;Cryoelectron Microscopy;Development;Disease;DNA;Environment;Gene Expression;Genes;Genetic Transcription;genome-wide;genome-wide analysis;Genomics;Goals;Health;Histones;Homologous Gene;Human;In Vitro;insight;Knock-out;Knowledge;laser tweezer;Lethal Genes;Life;Mediating;Methods;Molecular;novel;Nucleosomes;optic tweezer;Outcome;Pathway interactions;Play;Polymerase;Positioning Attribute;Process;Proteins;recruit;Regulation;RNA Polymerase II;Role;single molecule;Somatic Cell;structural biology;Structure;Techniques;Testing;Transcription Elongation;transcription factor;ultra high resolution;Work;Yeasts

PROJECT_TITLE: Investigate the function of NDF in chromatin dynamics and gene expression

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Among all organs in the body, we understand the brain least–we still do not know how the brain controls movement. This work seeks to uncover explanations on how the brain controls voluntary movement in settings like walking and running. This new insight will be critical to developing better recovery treatments for people with movement disabilities.

PI_NAMEs: NUYUJUKIAN, PAUL  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TITLE: Motor neural dynamics of free behavior enabled through 3D computer vision

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-SMN-B(90)S]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE When a child has a stroke, the injury to the brain can cause seizures immediately and epilepsy later after the brain heals. The “Seizures and Children's Outcomes after Stroke (SCOUTS)” study will help us understand how inflammation is related to both early seizures and epilepsy, and the networks in the brain that are most vulnerable to epilepsy after a child has a stroke. We will use this knowledge to provide more accurate prognoses early after a stroke and to select promising anti-inflammatory treatments to study for prevention of post-stroke epilepsy.

PI_NAMEs: FOX, CHRISTINE K. (contact)

PROGRAM_OFFICER_NAME: HOMMER, REBECCA EVE

PROJECT_TERMS: 19 year old;Acute;acute stroke;Anatomy;Ancillary Study;Animal Model;Animals;Anti-Inflammatory Agents;Area;Biological;Biological Assay;Blood Banks;Blood Vessels;Brain;Brain Injuries;Brain region;Child;Childhood;Childhood stroke;Chronic;Clinical Data;clinical imaging;Clinical Trials;Cognitive;cognitive development;cohort;Cohort Studies;connectome data;Data;data repository;Data Set;design;Development;differential expression;Enrollment;Epilepsy;Epileptogenesis;Family;Funding;Future;healing;Health;high risk;Human;improved;Incidence;inclusion criteria;Infarction;Infection;Inflammation;Inflammatory;inflammatory marker;Information Networks;Infrastructure;Injury;Institution;Interferon Type II;Intervention;Ischemic Stroke;Knowledge;Laboratories;Lesion;Libraries;Life;Link;Location;longitudinal dataset;Machine Learning;machine learning method;Maps;Measures;Mediator;Modeling;Molecular;Motor;neuroimaging;novel;novel strategies;Outcome;Pathway interactions;Plasma;post stroke;prevent;Prevention;Preventive therapy;Prognosis;prognostication;Quality of life;Recovery;Reproducibility;Research;Risk;Risk Reduction;Role;Sampling;Seizures;Serum;Signal Pathway;Signal Transduction;Stroke;stroke outcome;stroke survivor;Study models;Symptoms;systemic inflammatory response;Techniques;Testing;Therapeutic Agents;Time;United States National Institutes of Health;Validation;Work

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Glaucoma is the second most common cause of blindness in the U.S. and the most common cause of blindness among African-Americans. An elevation in intraocular pressure caused by the restriction of aqueous humor outflow through the trabecular meshwork is a common risk factor. The goal of this project is to identify signaling pathways that contribute to the restriction in outflow facility and determine if inhibiting these mechanisms can be used as potential therapies to increase outflow facility.

PI_NAMEs: PETERS, DONNA M (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Actins;Adenovirus Vector;Affect;African American population;anterior chamber;Aqueous Humor;Binding Proteins;Biological Assay;Biological Process;Blindness;Cannulations;caveolin 1;Cell Line;Cells;Cilengitide;Complex;connective tissue growth factor;crosslink;Cyclosporine;Cytoskeleton;Deposition;Dexamethasone;Event;Extracellular Matrix;Family;Glaucoma;Glucocorticoids;Goals;Grant;Guanosine Triphosphate Phosphohydrolases;Homeostasis;Human;Immunofluorescence Microscopy;Immunoprecipitation;in vivo;inhibitor;Injections;Integrin alphaVbeta3;Integrin Binding;Integrin Signaling Pathway;Integrins;intravitreal injection;ITGB3 gene;knock-down;Ligation;LoxP-flanked allele;Measures;Mediating;Microscopy;Monitor;Mus;nerve damage;new therapeutic target;NFAT Pathway;nuclear factors of activated T-cells;Ocular Hypertension;Optic Nerve;optic nerve disorder;Persons;Phagocytosis;Phagocytosis Inhibition;Phenotype;Physiologic Intraocular Pressure;Play;prevent;Process;Production;protein expression;Recombinant Proteins;Regulation;response;Retinal Ganglion Cells;Risk Factors;Role;Signal Pathway;Signal Transduction;Sirolimus;Small Interfering RNA;Steroids;Talin;Tamoxifen;Testing;therapeutic target;Tissues;Trabecular meshwork structure;transcription factor;transcriptome;transcriptome sequencing;Transforming Growth Factor beta;Transgenes;Up-Regulation;Western Blotting

PROJECT_TITLE: Control of Trabecular Meshwork Cytoskeleton

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(02)M]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE The formin family of proteins nucleates and directs the elongation of unbranched actin filaments that are incorporated into a variety of specialized bundled actin structures, enabling cells to perform essential processes such as division, motility and transport. Mutations in formin genes are associated with a number of human diseases including neurological disorders, microcephaly, dilated cardiomyopathy, and cancer. By elucidating a detailed understanding of the relationship between the physical properties of formins and their biological functions, we seek to gain insight into the large number of cellular processes regulated by formins and establish a molecular basis for understanding formin-related diseases.

PI_NAMEs: COURTEMANCHE, NAOMI  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TITLE: Molecular mechanisms of bundled actin structure assembly by formins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(02)M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative The proposed study seeks to identify common mechanisms underlying vascular and neuro-degeneration associated with cognitive impairment and early AD pathogenesis; thus, providing insight into causal molecular processes for disease-modifying interventions.

PI_NAMEs: LIU, YONGMEI  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Acceleration;adjudication;Affect;African American;Age;Aging;aging biomarker;aging mechanism;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-42;Amyloid beta-Protein;arterial stiffness;Atherosclerosis;Autophagocytosis;Biological Markers;Blood Vessels;Brain;Brain imaging;brain magnetic resonance imaging;cardiometabolic risk;cardiometabolism;Carotid Arteries;Cells;Cerebrovascular Circulation;Chinese;Clinical;clinical imaging;Cognitive;cognitive testing;cohort;Communities;Coupled;Data;Dementia;dementia risk;Diagnosis;Disease;DNA;DNA methylation profiling;Epigenetic Process;ethnic diversity;experimental study;FOXO3A gene;gene network;genome sequencing;Genomics;Glial Fibrillary Acidic Protein;Goals;hallmarks of aging;Hippocampus;Hispanic;Human;imaging biomarker;Impaired cognition;Impairment;improved;In Vitro;in vivo;insight;Intervention;late life;Light;Link;longevity gene;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;methylomics;middle age;mild cognitive impairment;Molecular;monocyte;mRNA sequencing;Multi-Ethnic Study of Atherosclerosis;Multiomic Data;Mus;Nerve Degeneration;Neurocognitive;neurofilament;Neurons;Participant;Pathogenesis;Pathology;Permeability;Plasma;Positron-Emission Tomography;predictive modeling;Process;proteostasis;racial diversity;screening;Signal Transduction;SIRT1 gene;Structure;tau Proteins;tau-1;Testing;Thick;Thinness;Time;transcriptomics;vascular cognitive impairment and dementia;Visit;White Matter Hyperintensity;whole genome;β-amyloid burden

PROJECT_TITLE: Common mechanistic biomarkers of vascular and neuro-degeneration

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Precision Medicine;Substance Misuse

ORG_CITY: TULSA

ORG_NAME: LAUREATE INSTITUTE FOR BRAIN RESEARCH

ORG_STATE: OK

PHR: NARRATIVE Deaths linked to opioid addiction are at an all-time high in the United States, and 50% of users relapse within three months of treatment, taking drugs to avoid aversive states linked to craving, withdrawal, negative emotions, and stress. There is a crucial need to understand impairments in brain circuitry driving these states at the outset of treatment and how they track patterns of recovery (abstinence versus relapse) within users, and between users and healthy individuals, during these pivotal first three months. Research on brain mechanisms of early recovery could serve to inform future targets for intervention (e.g., novel brain neurofeedback treatments) and aid the development of a precision medicine approach to reduce drug-related deaths.

PI_NAMEs: STEWART, JENNIFER LORRAINE (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Abstinence;addiction;Affect;Age;Anterior;anxiety sensitivity;Attention;Automobile Driving;Awareness;Behavioral;behavioral phenotyping;biobehavior;Biological Process;biological sex;bodily sensation;Brain;brain based;brain circuitry;brain dysfunction;Brain region;Cardiac;Cessation of life;Chronic;cingulate cortex;Corpus striatum structure;craving;cue reactivity;Cues;Data;Data Set;depressive symptoms;Development;dimensional analysis;Dimensions;directed attention;drug craving;Drug usage;drug withdrawal;early detection biomarkers;Emotions;Esthesia;Ethics;follow-up;Functional Magnetic Resonance Imaging;Future;high risk;Impairment;improved;Individual;individualized medicine;Insula of Reil;Intervention;Knowledge;Link;longitudinal design;Measures;men;mindfulness-based stress reduction;mortality;National Institute of Drug Abuse;negative affect;Negative Reinforcements;neurofeedback;neuroimaging;novel;Opiate Addiction;Opioid;opioid use disorder;opioid user;Pain;Pain interference;Participant;Patient Self-Report;Pattern;persistent symptom;Persons;Pharmaceutical Preparations;precision medicine;Process;prolonged abstinence;prospective;Public Health;Punishment;Recording of previous events;Recovery;recruit;Relapse;relapse prevention;relapse risk;Research;Resources;response;Rewards;rumination;Sampling;Signal Transduction;stimulant use disorder;Stimulus;Stress;stress reactivity;Stressful Event;substance use;substance user;System;Testing;Time;United States;Urine;Visit;Withdrawal;Withdrawal Symptom;Woman

PROJECT_TITLE: Plasticity of Aversive Salience in Opioid Use Disorder


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: People with temporal lobe epilepsy undergoing surgical procedures targeting the medial temporal lobe are at high risk for post-surgical memory decline, yet techniques for accurately predicting memory decline are lacking. Patients implanted with intracranial electrodes during inpatient seizure monitoring present a unique opportunity to leverage neurostimulation to induce a functional lesion and map memory-critical structures. The goal of this proposal is to characterize the spatial specificity of neurostimulation for functional lesion mapping during memory testing with the ultimate goal of developing a reliable protocol for individualized prediction of memory outcomes.

PI_NAMEs: KAESTNER, ERIK JORDAN (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Ablation;Address;Amobarbital;Anatomy;Benchmarking;Biometry;Brain;California;career;Characteristics;Clinical;clinical application;Clinical Research;Cognition;Cognitive;cognitive enhancement;cognitive function;cognitive neuroscience;Data Set;Development;Diagnostic tests;Drug resistance;Electric Stimulation;Electrical Engineering;Electrodes;Electrophysiology (science);Ensure;Epilepsy;Evolution;Excision;Foundations;Frequencies;Functional Magnetic Resonance Imaging;Funding;Goals;high risk;Impaired cognition;Implant;Implanted Electrodes;improved;individual patient;Infrastructure;innovation;Inpatients;Intervention;Intracarotid;Intractable Epilepsy;Lasers;Lesion;Magnetic Resonance Imaging;Maps;Measures;Medial;medial temporal lobe;Memory;Memory Loss;Mentors;Mentorship;Methods;Monitor;multidisciplinary;National Institute of Neurological Disorders and Stroke;Neurobiology;Neurologist;Neuropsychological Tests;neuroregulation;Neurosurgeon;neurosurgery;Operative Surgical Procedures;Outcome;Patient-Focused Outcomes;Patients;Performance;personalized predictions;Persons;Pharmaceutical Preparations;Physiologic pulse;Physiological;Positioning Attribute;Postoperative Period;preservation;Procedures;Protocols documentation;Quality of life;Research;Research Design;Research Institute;Research Personnel;Research Project Grants;research study;Resolution;Risk;Risk Assessment;Risk Estimate;Scientist;Seizures;Side;Site;Spatial Distribution;Specificity;Stimulus;Structure;Targeted Research;Techniques;Temporal Lobe Epilepsy;Testing;Time;Tissues;Training;Training Activity;translational impact;Translational Research;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Development of a personalized neurostimulation protocol for memory mapping in epilepsy

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Digestive Diseases;Genetic Testing;Genetics;Prevention;Rare Diseases;Stomach Cancer;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Hereditary loss-of-function variants in the CTNNA1 gene may be associated with increased risk of gastric and/or breast cancer, however the breadth and magnitude of the cancer risks associated with this gene remain poorly understood. This study will define the cancer penetrance in CTNNA1 loss-of-function variant carriers and will develop laboratory assays to further refine these cancer risks in a variant-specific manner. The combined results from this work will enable variant-specific CTNNA1 cancer risk determination, which will lay important groundwork to allow for appropriate clinical management of cancer risk in CTNNA1 loss-of-function variant carriers as well as their family members.

PI_NAMEs: KATONA, BRYSON WILLIAM (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: 3-Dimensional;Accounting;Adhesions;Affect;alpha catenin;Architecture;beta catenin;Binding;Biological Assay;Biopsy;Breast Cancer Detection;C-terminal;Cadherins;Calcium;cancer risk;Carcinogenicity Tests;CDH1 gene;Cell membrane;Cell Physiology;Cells;Clinical Management;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;Collection;Cytoplasmic Tail;Data;data collection methodology;Development;Diffuse;Diffuse gastric cancer;disease-causing mutation;Dysplasia;E-Cadherin;Enrollment;Event;Family;Family history of;Family member;gastric organoids;Gastric Tissue;gastric tumorigenesis;Generations;Genes;genetic panel test;genetic pedigree;genomic profiles;Genotype;Germ Lines;Germ-Line Mutation;Goals;Heritability;Histology;Homeostasis;improved;indexing;Individual;Inherited;Laboratories;Lobular;loss of function;Malignant Breast Neoplasm;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Medical;Medical History;Modeling;Molecular;Morphology;N-terminal;Organoids;Participant;Patients;Penetrance;Penetrance analysis;Phenotype;Proliferation Marker;prospective;protein function;Proteins;Recording of previous events;recruit;Regulation;Reporting;Risk;Risk Estimate;Risk Management;risk variant;screening;Serial Passage;Syndrome;Time;Tissues;tool;TP53 gene;Tumor Markers;tumor progression;tumorigenic;Uncertainty;Variant;variant detection;Work

PROJECT_TITLE: Defining the phenotype and cancer penetrance of CTNNA1 loss-of-function germline variants