NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: Project Narrative RNA interference has an ancient role in epigenetic silencing and chromosome stability, independent of its well-known function in post-transcriptional gene regulation through microRNA. We are investigating mechanisms underlying this role in yeast and mammalian cells, and we have discovered deeply conserved pathways that link RNA interference with transcription, replication and quiescence. Interaction with the transcriptional co-activator BRD4, and with other epigenetic regulators, leads to genome instability with implications for targeted therapies in cancer and autoimmune disease.

PI_NAMEs: MARTIENSSEN, ROBERT A (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Autoimmune Diseases;Biological Models;Bromodomain;Caenorhabditis elegans;Cell Cycle;Chromosomal Stability;Chromosome Segregation;Chromosomes;Disease;DNA;DNA Damage;DNA Repair;DNA replication fork;Drosophila genus;Epigenetic Process;epigenetic silencing;Event;Fission Yeast;Gene Expression Regulation;Gene Silencing;Genetic Screening;Genetic Transcription;genome integrity;Genome Stability;Genomic Instability;Germ Lines;Goals;Health;Heterochromatin;heterochromatin-specific nonhistone chromosomal protein HP-1;histone methylation;histone modification;homologous recombination;Hybrids;Link;Liquid substance;Malignant Neoplasms;Mammalian Cell;Mediating;MicroRNAs;Mouse Embryonic Stem Cells;mutant;Mutant Strains Mice;novel;Pathway interactions;Phase;Phase Transition;piRNA;Polymerase;Post-Transcriptional Regulation;prevent;Property;recruit;repaired;Repetitive Sequence;Research;Ribonuclease H;RNA;RNA Interference;RNA Polymerase II;Role;S phase;stem cell model;Structure;System;targeted treatment;Transcription Coactivator;Ubiquitin;ubiquitin ligase;Untranslated RNA;Work;Yeasts

PROJECT_TITLE: RNA Interference and Heterochromatic Silencing in Replication and Quiescence

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: EB

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Women's Health Research

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Narrative: Breast cancer is identified in ultrasound scans on the basis of telltale image features, including the presence of “shadows” behind lesions due to their ultrasound absorption. This shadowing can be difficult to detect and obscured by variations in image brightness from benign causes. We propose to construct and test a new ultrasound system to robustly image ultrasound absorption for better classification of breast lesions. This system will be evaluated in tissue-like materials and in mastectomy breast tissue samples.

PI_NAMEs: MCALEAVEY, STEPHEN A (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: absorption;acoustic imaging;Acoustics;Area;attenuation;Benign;Biopsy;Breast biopsy;breast imaging;breast lesion;Breast Microcalcification;Categories;Classification;Computer Models;contrast imaging;Data;Descriptor;design;Development;Diagnostic;Distal;Elasticity;elastography;electric impedance;Equipment;Focused Ultrasound;Geometry;Goals;Human;Image;imaging system;improved;in vivo;Lesion;Location;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Ultrasonography;Maps;Mastectomy;Measurement;Measures;Mechanics;Methods;Modulus;Morphologic artifacts;Parameter Estimation;parametric imaging;Patients;Performance;Physicians;Predictive Value;Property;Radiation;Research;Resolution;Shapes;simulation;sound;Source;Speed;success;System;Testing;Tissue imaging;Tissue Sample;Tissues;transmission process;Ultrasonics;Ultrasonography;ultrasound;Variant;women's diagnosis

PROJECT_TITLE: Shear Wave Reciprocity for Breast Imaging

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cachexia;Cancer;Clinical Research;Digestive Diseases;Liver Disease;Nutrition;Pancreatic Cancer;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The wasting syndrome cachexia is a major determinant of mortality in pancreatic cancer. We have found that pancreatic cancer markedly alters liver metabolism. We will investigate the deregulation of hepatic metabolism by PDAC, its role in cancer cachexia, and the circulating signals that mediate these changes.

PI_NAMEs: GROSSBERG, AARON  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Adaptor Signaling Protein;Adipose tissue;Biochemical;Blood Glucose;Cachexia;Cancer Cachexia;Cancer Patient;carbohydrate metabolism;Carbohydrates;Caring;Catabolism;Cells;circadian;circadian biology;Circadian Dysregulation;Circadian gene expression;circadian regulation;Complication;Critical Pathways;Darkness;Data;design;detection of nutrient;Disease;Dissociation;Distant;effective therapy;energy balance;Excision;Fasting;feeding;Feeding behaviors;FRAP1 gene;Functional impairment;Gastrointestinal tract structure;Gene Expression;Genes;Goals;Hepatic;Hepatocyte;Homeostasis;Human;Immune;improved;inhibitor;insight;Intervention;K-Series Research Career Programs;ketogenesis;ketogentic;Ketones;life span;Link;lipid biosynthesis;lipid metabolism;Lipids;Liver;liver metabolism;Macronutrients Nutrition;Malignant neoplasm of pancreas;Malignant Neoplasms;Malnutrition;Measures;Mediating;Mentors;Mentorship;Metabolic;metabolic phenotype;Modification;molecular marker;Monitor;mortality;Mortality Determinants;Mus;Muscle;muscle form;new therapeutic target;Nutrient availability;Nutritional;nutritional supplementation;Organ;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;Patients;Periodicals;Peripheral;Phenotype;Phosphotransferases;Physicians;Physiology;prevent;programs;Quality of life;Regulation;Research Personnel;Resistance;response;Role;Sampling;Scientist;Signal Transduction;Sirolimus;Site;Skeletal Muscle;targeted treatment;Testing;therapeutically effective;Thinness;Time-restricted feeding;Tissues;Training;transcriptome sequencing;translational approach;TSC1 gene;tumor;Tumor Biology;tumor growth;tumor metabolism;Venous;wasting;Wasting Syndrome

PROJECT_TITLE: Hepatic metabolic reprogramming drives pancreatic cancer cachexia

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AI

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Infectious Diseases;Lyme Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: TEMPE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative A novel antigen discovery approach will be applied for comprehensive profiling of temporal evolution of the humoral immune response in patients with Lyme disease differentiating between two treatment outcomes: return to health/show minor symptoms or Post Treatment Lyme Disease Syndrome (PTLDS) - a poorly understood condition with a clinical presentation affecting 10-15% of Lyme disease patients. Here, a longitudinal, prospectively collected patient cohort will be utilized to predict and validate which Borrelia burgdorferi and human protein antigens are associated with the progression from confirmed acute disease, through treatment to PTLDS. By identifying which antigens are immunogenic, it is sought to develop a set of immunologic biomarkers for predicting progression to PTLDS early in the acute phase of the disease thus providing a window of opportunity for early intervention and symptom management.

PI_NAMEs: WOODBURY, NEAL WALTER (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Acute;Acute Disease;Affect;Aftercare;Algorithms;Amino Acids;Antibiotic Therapy;Antibodies;Antibody Repertoire;Antibody Response;Antigens;Arthralgia;Autoimmune;Autoimmune biomarker;Autoimmune Diseases;Autoimmune Responses;Binding;Biological;Biological Assay;Biological Markers;biomarker identification;biomarker panel;Borrelia;Borrelia burgdorferi;candidate identification;candidate marker;Centers for Disease Control and Prevention (U.S.);Chronic Disease;Clinical;Clinical Treatment;cohort;combinatorial;cross reactivity;Data;Development;Diagnosis;Diagnostic;diagnostic tool;Disease;disease model;Disease Outcome;Disease Progression;early detection biomarkers;Early Intervention;Epitopes;Evolution;experience;Fatigue;Financial Hardship;Future;Generations;Goals;Health;Healthcare Systems;Heterogeneity;high risk;Human;Immune response;Immunoassay;immunogenic;Immunologic Markers;Immunologics;Impaired cognition;improved;in silico;Incidence;interest;Knowledge;Length;Libraries;Link;long-term sequelae;Longitudinal cohort;Lyme Disease;Machine Learning;machine learning model;machine learning prediction;Minor;Molecular;Molecular Diagnostic Testing;molecular diagnostics;novel;Outcome;Outcome Study;pathogen;Pathology;patient stratification;Patients;Pattern;Peptides;Performance;Phase;Physicians;Post Treatment Lyme Disease Syndrome;prediction algorithm;predictive marker;predictive modeling;predictive panel;Predisposition;Prevalence;profiles in patients;progression risk;prospective;protein biomarkers;Proteins;Proteome;Quality of life;Research;response;Risk;Risk Assessment;risk prediction;Sampling;Serum;symptom management;symptom treatment;Symptoms;System;Targeted Research;targeted treatment;Testing;Therapeutic;Tick-Borne Diseases;Time;Training;Treatment outcome;United States;Validation;Work

PROJECT_TITLE: Discovery of early immunologic biomarkers for risk of PTLDS through machine learning-assisted broad temporal profiling of humoral immune response


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Human herpes simplex virus 2 (HSV-2) is an extremely common, incurable sexually transmitted infection that causes genital ulcers. For unclear reasons, some chronically infected individuals experience frequently recurrent symptoms while others experience no symptoms. This project will investigate the role of the virus in determining the symptomatic severity of HSV-2 infection, information that can ultimately be used to improve treatments for viral infection and to reduce viral transmission.

PI_NAMEs: CASTO, AMANDA  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Affect;Animal Model;Animals;Area;Award;Bioinformatics;Biological Models;Biometry;Biopsy;career development;Cavia;Chronic;chronic infection;Clinical;Code;Communicable Diseases;Communication;Data;Data Analyses;Data Set;Dedications;Development Plans;differential expression;Disease;ds-DNA;Educational workshop;Equilibrium;experience;experimental study;Frequencies;Future;Gene Expression;Genes;Genetic study;genetic variant;Genetic Variation;genital herpes;Genitalia;Genome;genome sequencing;genome wide association study;Genotype;Goals;guinea pig model;Herpesvirus 1;Heterogeneity;Human;human DNA;Human Herpesvirus 2;Hypersensitivity;Immune;Immune Evasion;Immune response;Immune system;immunodeficiency;Immunosuppression;improved;In Vitro;in vivo;in vivo Model;Individual;Infection;insight;instructor;Integration Host Factors;International;Investigation;keratinocyte;Laboratories;Lesion;Mediating;Mediator;meetings;Mentors;Methods;microbial genome;Mutation;Nucleic Acid Regulatory Sequences;pathogen;Pathogenesis;Persons;Phenotype;Physicians;Play;Poly A;Recurrence;reproductive tract;Research;Research Personnel;RNA Viruses;Role;Running;Sampling;Scanning;Scientist;Severities;Severity of illness;Sexual Transmission;Sexually Transmitted Diseases;Simplexvirus;skill acquisition;skills;Skin;stem;Subcutaneous Tissue;Swab;symposium;Symptoms;trait;Transcript;transcriptome sequencing;Twin Studies;Ulcer;Universities;Variant;Viral;Viral Genes;viral genomics;viral transmission;Virus;Virus Diseases;Virus Replication;Washington;whole genome;Work

PROJECT_TITLE: Investigation of the impact of viral factors on the severity of chronic HSV-2 infection

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: GALVESTON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: Project Narrative Spotted fever rickettsioses are potentially life-threatening diseases. Since no licensed vaccine is available, we aim to develop vaccine candidates and investigate how a vaccine protects spotted fever rickettsioses using animal models. This research will to help us to prevent these tick-transmitted diseases.

PI_NAMEs: FANG, RONG MEGAN (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Animal Model;Animals;anti-tick vaccine;Antibodies;Arthropods;Attenuated;Attenuated Vaccines;Bacteria;Bacteriophages;Brazil;Bypass;Case Fatality Rates;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Immunity;cross immunity;Development;Diagnostic Procedure;Disease;disease transmission;Dose;efficacy evaluation;Elements;Ensure;Evaluation;Experimental Models;Genes;Genetic Engineering;Goals;Gram-Negative Bacteria;Hand;Health;Human;Humoral Immunities;Immune;Immune signaling;Immunity;Immunization;Immunize;immunogenicity;Immunoglobulin G;Immunologics;immunoprophylaxis;In Vitro;Incidence;Infection;innovation;insight;Integrase;Interferon Type II;Interferons;Intravenous;Left;Lesion;Licensing;Life;Memory;Modeling;mouse model;Mus;Mutagens;mutant;Needles;neutralizing antibody;novel;novel strategies;novel vaccines;pathogen;Pathogenicity;Pathologic;Phenotype;Pilot Projects;Polyvalent Vaccine;prevent;Prevention;protective efficacy;Proteins;Public Health;Publishing;rational design;Reporting;Research;Resources;Rickettsia;Rickettsia Infections;Rickettsia parkeri;Rifampicin resistance;Rocky Mountain Spotted Fever;Role;Safety;Signal Transduction;spotted fever;T memory cell;Testing;tick bite;tick transmission;tick-borne;Ticks;TLR4 gene;transmission process;United States;Vaccination;vaccine access;vaccine candidate;Vaccine Design;vaccine development;vaccine efficacy;vaccine trial;vaccine-induced immunity;Vaccines;Virulence;virulence gene;Virulent

PROJECT_TITLE: Rational development of a vaccine against tick-borne rickettsioses

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative Dysregulation of myelopoiesis can be either cell-intrinsic or cell-extrinsic, however, these two mechanisms are not necessarily mutually exclusive and the cause of aberrant myelopoiesis in certain diseases is not always clear. Interestingly, we show that a cell-extrinsic emergency myelopoiesis progressively develops when the inner mitochondrial membrane transporter ABCB7 is conditionally deleted in differentiating B cells in the bone marrow. As ABCB7 levels are decreased due to mis-splicing when the splicing factor SF3B1 is mutated, we hypothesize that patients with SF3B1-mutated myelodysplastic disease may not be strictly cell-intrinsic, but instead is mediated by decreased expression of ABCB7 in B-lineage precursor cells.

PI_NAMEs: MEDINA, KAY LYNN;SHAPIRO, VIRGINIA SMITH (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Address;Alleles;Anemia;Autoimmune Diseases;B cell differentiation;B-Cell Development;B-Lymphocytes;bone loss;Bone Marrow;CD34 gene;Cell Lineage;Cells;Chronic;Compensation;Data;Defect;Development;Disease;DNA Damage;Dysmyelopoietic Syndromes;Emergency Situation;Engineering;Erythropoiesis;Exhibits;Exons;Generations;Grant;Hematology;Hematopoiesis;Hematopoietic;Human;humoral immunity deficiency;Inflammation;Inflammation Mediators;Inner mitochondrial membrane;Iron Overload;Knock-out;Marrow;Mediating;Membrane Transport Proteins;mouse model;Mus;Mutate;Mutation;Myelogenous;Myeloid Cells;Myelopoiesis;Myeloproliferative disease;Nonsense Codon;Nonsense-Mediated Decay;novel;old mice;Patients;Population;precursor cell;progenitor;Reporter;Risk;RNA;RNA Splicing;Role;Site;Spleen;Spliced Genes;stem cells;Stimulus;Stress;systemic inflammatory response;Testing;Therapeutic;Transcript;Xenograft Model

PROJECT_TITLE: Cell-extrinsic emergency myelopoiesis regulated by ABCB7

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Women in South Asia, including India, often migrate from their husbands’ home back to their parents’ home in pregnancy and for delivery, which may have implications for maternal and child heath, yet this phenomenon is understudied. We will conduct a multisite longitudinal study in India to understand and describe this phenomenon (which we call temporary childbirth migration) and measure its impact on infant and maternal health, with a primary outcome of preterm birth.

PI_NAMEs: DIAMOND-SMITH, NADIA GRIFFI (contact);EL AYADI, ALISON M

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: affection;Area;Asia;Asian Women;Back;Birth;Breast Feeding;care outcomes;Caring;Cellular Phone;Cessation of life;Child;Child health care;Childbirth;Coin;Communities;Comprehensive Health Care;Continuity of Patient Care;Contraceptive Agents;cost;Data;Data Collection;data collection site;Dimensions;Disadvantaged;Dose;early pregnancy;Economics;Emotional;Empathy;Ensure;family support;Geographic Distribution;Geography;Health;health care availability;health care delivery;Health Policy;health practice;health record;Healthcare;Heterogeneity;Home;Household;Housekeeping;Husband;improved;India;Infant;Infant Care;Infant Health;infant outcome;Interview;Laws;Left;Literature;Longitudinal cohort;Longitudinal Studies;Maternal and Child Health;Maternal Health;maternal morbidity;maternal outcome;Measurement;Measures;Mediator;Medical Records;member;Migrant;migration;Modeling;mortality;Mothers;National Institute of Child Health and Human Development;neonatal health;Neonatal Mortality;Newborn Infant;Outcome;Parents;Pathway interactions;Pattern;Perinatal Care;perinatal health;perinatal outcomes;perinatal period;perinatal women;Personal Satisfaction;Phase;Policies;postnatal;Postpartum Period;Postpartum Women;Pregnancy;Pregnancy Outcome;Pregnant Women;Premature Birth;Prenatal care;Prevalence;primary outcome;programs;Public Health;recruit;Risk;secondary outcome;Site;Social support;sociodemographic factors;sociodemographics;South Asian;Surveys;Telephone;time use;uptake;Vaccination;Visit;Woman;Women Status

PROJECT_TITLE: Temporary childbirth migration: understanding the magnitude and implications for maternal and infant health

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE The glycosylated hemoglobin (HbA1c) test is considered highly valuable for early detection of diabetes but is currently not recommended for use among persons living with HIV (PLHIV) due to their lower hemoglobin levels. This study will identify appropriate HbA1c diagnostic thresholds for strata of hemoglobin and markers of inflammation, insulin resistance, and immuno-virologic status, in addition to evaluating an alternative glycated test, fructosamine, with no hemoglobin limitation. Findings will inform the development of guidelines for the optimal use of glycated testing tools among PLHIV and others with low hemoglobin in the general population.

PI_NAMEs: JUMARE, JIBREEL  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Adopted;Age;Algorithms;Area Under Curve;Biological Markers;Blood specimen;C-reactive protein;CD4 Lymphocyte Count;clinical care;clinical center;Clinical Chemistry;clinical practice;cohort;Collaborations;Data;design;Development;Diabetes Mellitus;diabetic;Diagnosis;Diagnostic;diagnostic accuracy;Disease;Early Diagnosis;Endocrinology;Evaluation;Fasting;Fructosamine;General Population;Glucose;Glucose tolerance test;glycation;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;Guidelines;Hemoglobin;Hemoglobin concentration result;HIV;Human;improved;Individual;Infectious Disease Epidemiology;inflammatory marker;instrument;Insulin;Insulin Resistance;International;Kidney Diseases;low and middle-income countries;Maryland;Measures;Microvascular Dysfunction;Modality;Monitor;multidisciplinary;Newly Diagnosed;Nigeria;OGTT;Outcome;Performance;Persons;Population;Prediabetes syndrome;Predictive Value;Questionnaires;Recommendation;recruit;Reporting;Research Personnel;Retinal Diseases;Risk;RNA;ROC Curve;screening;Sensitivity and Specificity;Serum Proteins;sex;Specificity;systemic inflammatory response;Teaching Hospitals;Testing;tool;trend;Universities;virology;World Health Organization

PROJECT_TITLE: Biomarker-Guided Evaluation of Glycated Testing Modalities for Dysglycemia among Persons Living with HIV (BEGET)

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Telehealth

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The proposed research will focus on developing a chatbot that using artificial intelligence to promote HIV testing among men who have sex with men (MSM) in Kuala Lumpur, Malaysia (My). Once developed and adequately tested, the new chatbot (named MyTestBot?) will be embedded into a social networking app selected by MSM to create an mHealth intervention to provide MSM with real-time HIV testing-related information, motivation, and behavioral skills. MyTestBot? will provide culturally tailored messages to promote HIV testing in MSM that does not rely on intensive human resources to develop and maintain.

PI_NAMEs: ALTICE, FREDERICK LEWIS;NI, ZHAO  (contact)

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Acceleration;acceptability and feasibility;AIDS prevention;Algorithms;Artificial Intelligence;Automation;Behavioral;biobehavior;Cellular Phone;Charge;chatbot;China;Clinic;clinical care;Communities;computer program;Computer Systems;Continuity of Patient Care;cost effective;Country;criminal behavior;Data;Data Analyses;Decision Making;design;Disclosure;Discrimination;Early Diagnosis;Early treatment;efficacy evaluation;efficacy outcomes;Epidemic;experience;Facebook;Frequencies;General Population;Guidelines;health management;Health Personnel;Health Services Accessibility;high risk behavior;high risk men;HIV;HIV/STD;Human;Human immunodeficiency virus test;Human Resources;humiliation;Hybrids;implementation outcomes;implementation science;Income;Individual;Infection;Injecting drug user;innovation;Intelligence;Intervention;Learning;low and middle-income countries;Machine Learning;machine learning algorithm;Malaysia;Malaysian;Manuals;Measures;Medical Students;member;men who have sex with men;Methods;mHealth;mhealth interventions;mobile application;model building;Modeling;Motivation;Names;new epidemic;next generation;Output;overtreatment;Participant;Patient Self-Report;Patients;Pattern;Persons;Peru;Phase;Physicians;pilot test;Police;Policies;Population;pre-exposure prophylaxis;Prevalence;Prevention strategy;Process;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Research Methodology;Research Personnel;response;Risk;same sex behavior;Same-sex;scale up;Sex Behavior;Sexual Partners;Sexual Transmission;simulation;skills;Social Network;social stigma;sodomy;South Africa;stem;Stigmatization;Subgroup;Substance Use Disorder;Surveys;tailored messaging;Target Populations;Television;Testing;theories;Time;Training;transmission process;treatment as usual;Universities;Viral;Volatilization;web site

PROJECT_TITLE: Developing an artificial intelligence-based mHealth intervention to increase HIV testing in Malaysia


NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Genetics;Rare Diseases;Skin Cancer

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative  Merkel cell carcinoma (MCC) is a primary neuroendocrine carcinoma of the skin; a highly aggressive cancer with a 40% 2-year mortality rate. Virus-negative MCC is caused by excessive sunlight exposure resulting in ultraviolet induced damage to the genome while virus-positive MCC is caused by integration of the MCPyV viral DNA into the host cell genome with expression of a truncated form of Large T antigen and an intact Small T antigen. We propose that the distinct mechanisms of oncogenesis in virus-negative-MCC and virus-positive-MCC provides us with the unique opportunity to use orthogonal methodologies to gain a clearer insight into the oncogenesis of MCC and other cancer types.

PI_NAMEs: DECAPRIO, JAMES A. (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Basal cell carcinoma;cancer type;Cause of Death;Cells;Child;Chromatin;Complex;Death Rate;Disease;Etiology;Gene Expression;Genes;Genome;immune checkpoint blockade;Incidence;insight;Large T Antigen;Learning;Lysine;Malignant Epithelial Cell;Malignant Neoplasms;Melanoma;Merkel cell carcinoma;Methodology;Mutation;MYCL1 gene;novel;Oncogenic;Pathway interactions;Pattern;Phenotype;posters;programs;RB1 gene;recruit;Signal Pathway;Skin Cancer;Small T Antigen;Squamous cell carcinoma;success;Sun Exposure;Time;tool;TP53 gene;Transferase;tumor;Tumor Suppressor Genes;tumorigenesis;ultraviolet;UV induced;Viral;viral DNA;Virus

PROJECT_TITLE: Identification of Novel Oncogenic Signaling Pathways using Viral Perturbations


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE This study employs a participatory systems science approach to increase organizational readiness, strengthen collaborations, and enhance efficacy to implement a cardiovascular disease risk reduction evidence-based program, Heart Matters, in rural North Carolina. Prior feasibility and efficacy testing of Heart Matters demonstrated improved blood pressure, physical activity, and social support for African American adults at risk for cardiovascular disease in this setting. The overall objective of this study is to train 18 organizations and establish a tested evidence-based program implementation blueprint that is sustainable beyond external funding and transferable to end-users.

PI_NAMEs: DAVE, GAURAV J (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Address;Adoption;Adult;Affect;African American;African American population;Behavior;behavioral outcome;Biological Markers;Blood Pressure;burden of illness;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Cholesterol;Clinic;Clinical;Collaborations;Communities;community academic partnership;comparison control;concept mapping;Consolidated Framework for Implementation Research;cost effective;cost effectiveness;County;dietary;disease disparity;Disease Outcome;Disparity;Effectiveness;effectiveness evaluation;effectiveness/implementation design;effectiveness/implementation study;efficacy testing;Eligibility Determination;Enrollment;Evidence based program;Faith;Faith-based organization;feasibility testing;feasibility trial;Feedback;Funding;Goals;Heart;high risk;Hybrids;implementation barriers;implementation context;implementation determinants;implementation evaluation;implementation outcomes;implementation strategy;improved;Individual;innovation;Knowledge;Learning;Maps;Methods;model building;Morbidity - disease rate;mortality;North Carolina;organizational readiness;Outcome;Participant;Patient Self-Report;Penetration;Physical activity;Protocols documentation;Randomized;Randomized, Controlled Trials;Readiness;recruit;Research;Risk Reduction;Rural;rural African American;Rural Community;rural counties;rural setting;Science;Site;Social support;stakeholder perspectives;success;System;Testing;Training;Translations;treatment arm;trial design;United States;uptake

PROJECT_TITLE: Heart Matters: Collaborate and Leverage Evidence in an African American Rural Network to Implement Risk Reduction Strategies for CVD (Heart Matters: Co-Learn to Reduce CVD)

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Precision Medicine

ORG_CITY: ITHACA

ORG_DEPT: NUTRITION

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative Precision nutrition approaches aim to move away from a one-size fits all approach to identify individual-level dietary and nutritional intake for optimal health by accounting for individual variability in genes, phenotype, environment, and lifestyle for each person (NIH) – i.e., tailoring nutrition interventions and/or recommendations to individuals by accounting for the complex nutritional ecology reflecting the interaction of a complex system. The 2020-30 Strategic Plan for NIH Nutrition Research, developed by the NIH Nutrition Research Task Force, identifies a key need to produce a nutrition workforce that is trained in Artificial Intelligence (AI) and machine learning (ML) to solve the most pressing problems in nutrition and health, by applying novel methods and working in multidisciplinary teams. We propose to leverage our existing strengths and initiatives at Cornell to implement a novel program to train the next generation of scientists in the domains of AI and precision nutrition to address the future needs for the nutrition workforce.

PI_NAMEs: ERICKSON, DAVID CARL;ESTRIN, DEBORAH ;JOACHIMS, THORSTEN ;MEHTA, SAURABH  (contact);TAMIMI, RULLA M;THOMAS, DIANA MARIA;WELLS, MARTIN TIMOTHY

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Artificial Intelligence;precision nutrition;Training Programs

PROJECT_TITLE: Artificial Intelligence and Precision Nutrition Training Program


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Complementary and Integrative Health;Dementia;Natural Products;Neurodegenerative

ORG_CITY: WINSTON-SALEM

ORG_DEPT: CHEMISTRY

ORG_NAME: WINSTON-SALEM STATE UNIVERSITY

PHR: NIH SuRE Project Narrative  This NIH SuRE proposal aims to develop highly selective metal catalyzed carbon carbon bond formation reactions that will lead to efficient synthesis of novel selenium, sulfur, and oxygen-containing heterocycles with rich biological activities. Further elaboration of this chemistry will likely allow the first enantioselective synthesis of very important classes of heterocycles such as biselenoflavonoids, bithioflavonoids and bioactive biflavonoids, potential small molecule therapeutics for Alzheimer’s disease. This SuRE project is expected to significantly enhance and expand the research capacity towards a sustainable research excellence that actively involves underrepresented minority students in funded research at WSSU, a HBCU.

PI_NAMEs: GUO, FENGHAI  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acylation;Alzheimer's disease therapeutic;analog;Bioflavonoid;Biological;biological systems;Carbon;catalyst;Chemistry;Communication;Complex;Coupling;Development;drug discovery;enolate;Funding;Generations;Heterocyclic Compounds;In Situ;innovation;Metals;Methods;Names;Natural Products;Nature;novel;novel strategies;nucleophilic addition;oxidation;Oxygen;Pharmaceutical Preparations;Pharmacologic Substance;Process;Reaction;Reproduction;Research;Selenium;small molecule therapeutics;Sulfur;Synthesis Chemistry;Therapeutic;underrepresented minority student;United States National Institutes of Health

PROJECT_TITLE: Development of Efficient Carbon Carbon Bond Formations for Novel Se-, S-, and O-Heterocycle Synthesis


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Complementary and Integrative Health;Genetics;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: COLUMBIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Anxiety and mood disorders are the most common mental health problem in adolescents, and are often associated with disruptions in both emotional processing and decision making. Widespread exposure to light from electronic devices before bedtime is a possible risk factor for developing psychiatric disorders. Using a translational mouse model, this project will explore the effects of altered patterns of light exposure on amygdala plasticity and emotion-related behavior in adolescent mice, which will potentially lead to new complementary strategies to advance health and well-being in human adolescents.

PI_NAMEs: PORCU, ALESSANDRA  (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affect;Amygdaloid structure;Anatomy;Anxiety;Anxiety Disorders;anxiety-like behavior;Award;Behavior;behavior test;Behavioral;Biological Assay;Brain;Brain region;Calcium;Calcium Signaling;Cells;Cellular Phone;Choice Behavior;Chronic;Complex;Computers;Confusion;Coupled;critical period;Data;Decision Making;design;Development;Electronics;Emotional;emotional behavior;Emotional disorder;Emotions;environmental change;experimental study;Exposure to;Feeling suicidal;Fiber;Gambling;gamma-Aminobutyric Acid;Gene Expression;Gene Expression Profile;Genes;genetic approach;Health;Human;Hypothalamic structure;Immunohistochemistry;Impairment;In Situ Hybridization;in vivo;Individual;Integrative Therapy;Iowa;Knowledge;Label;Light;light effects;Lighting;Link;Medial;Mediating;Mental disorders;Mental Health;Mentorship;Modernization;Mood Disorders;Moods;mouse model;Mus;neural;neural circuit;Neurobiology;Neuronal Plasticity;Neurons;Neurosciences;Neurotransmitters;Output;Pathway interactions;Pattern;Personal Satisfaction;pharmacologic;Phase;Photometry;Play;Population;Positioning Attribute;postsynaptic;Predisposition;Process;Property;Protocols documentation;Puberty;Recording of previous events;Reporting;Research;response;Risk;Risk Behaviors;Risk Factors;Risk Taking;RNA;Rodent;Role;screening;Signal Transduction;single-cell RNA sequencing;Societies;Somatostatin;Structure;Structure of terminal stria nuclei of preoptic region;Supervision;Tablets;Testing;transcriptome sequencing;Well in self;Youth

PROJECT_TITLE: Effects of light exposure on amygdala plasticity during adolescence: implications for anxiety and well-being


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative To stem increasing rates of HIV among gay and bisexual men in Central-Eastern Europe, we will establish the feasibility, acceptability, and early efficacy of a culturally adapted evidence-based program to introduce pre- exposure prophylaxis (PrEP) into Romania’s healthcare practice. PrEP Romania, a hybrid in-person + mHealth PrEP uptake and adherence program, aims to empower gay and bisexual men and their healthcare system to adopt PrEP and support adherence. Findings can inform evidence-based PrEP rollout in other Central-Eastern European countries with similar levels of unpreparedness for biomedical prevention.

PI_NAMEs: LELUTIU-WEINBERGER, CORINA  (contact);PACHANKIS, JOHN EDWARD

PROJECT_TERMS: acceptability and feasibility;Accountability;Acquired Immunodeficiency Syndrome;Address;Adherence;Administrator;Adopted;AIDS prevention;Alcohol abuse;arm;Attitude;Automobile Driving;Behavioral;Biological Markers;Bisexual;Blood;Cities;Clinic;Communicable Diseases;community organizations;condoms;Counseling;Country;Data;Dryness;Eastern Europe;Education;Effectiveness;effectiveness trial;effectiveness/implementation trial;Elements;Eligibility Determination;empowerment;Enrollment;Epidemic;European;evidence base;Evidence based program;experience;Feedback;Foundations;Future;Gays;Health;Health Personnel;Healthcare;Healthcare Systems;HIV;HIV/STD;Homophobia;Hybrids;implementation framework;implementation outcomes;Incidence;Individual;Institution;Intervention;Interview;Knowledge;live text;Locales;Mediator;Medical;men;Mental Depression;Mental Health;mHealth;mhealth interventions;Mobile Health Application;Modeling;Motivation;motivational intervention;Patient Self-Report;Persons;Physicians;pilot test;Population;Positioning Attribute;pre-exposure prophylaxis;prevent;Prevention;Prevention strategy;preventive intervention;Privatization;Professional counselor;programs;Protocols documentation;Provider;Randomized;Randomized, Controlled Trials;Reporting;Research;Risk;Romania;scale up;Self Direction;Self Efficacy;sex;Sexual Health;social engagement;Social Network;Spottings;staff intervention;stem;Stigmatization;Testing;Text;tool;Training;Unsafe Sex;uptake;usability;Visit;Work;working group

PROJECT_TITLE: Preparing for pre-exposure prophylaxis implementation in Central-Eastern European Countries with low access to biomedical prevention


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease;Urologic Diseases

ORG_CITY: SALSBURY COVE

ORG_NAME: MOUNT DESERT ISLAND BIOLOGICAL LAB

ORG_STATE: ME

PHR: Relevance The course Origins of Renal Physiology is highly relevant to biomedical research and the advancement of human health. The number of annual participants (up to 36; 25 of whom will be funded through this grant) represents approximately 10% of the annual “class” of renal fellows in the United States, permitting the course to have a significant impact on the training of fellows nationally. Course faculty include clinical nephrologists and investigators who guide participants in performing experiments to elucidate kidney function including glomerular filtration, proximal tubule, thick ascending limb, and collecting duct transport, water homeostasis, cellular trafficking of transporter proteins, and the structure-function of transporter proteins such as aquaporins, urea carriers, renal stone disease, ENaC and the Na/K/2Cl cotransporter, and participants will also receive relevant case study-based training in Responsible Conduct in Research.

PI_NAMEs: ZEIDEL, MARK L. (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acids;Address;base;Biological;Biomedical Research;Bladder;career;Carrier Proteins;Case/Control Studies;Clinical;clinical training;Confocal Microscopy;cost;course module;Cultured Cells;Disease;Duct (organ) structure;editorial;education research;Educational process of instructing;Electrodes;epithelial Na+ channel;Equilibrium;experimental study;Faculty;Fees;Foundations;Funding;Future;Genetic;glomerular filtration;Grant;hands on research;Health;Homeostasis;Human;Human Resources;improved;insight;Instruction;Kidney;Kidney Calculi;Kidney Diseases;Laboratories;Lead;Limb structure;Link;Maine;Medical;Methods;Modernization;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;Outcome;Participant;physiologic model;Physiology;Process;programs;Recording of previous events;Renal function;Research;Research Personnel;Rotation;Running;Schedule;Services;single molecule;Sodium;Sodium Chloride;Structure;symporter;Thick;toad;tool;Touch sensation;trafficking;Training;Translating;Travel;United States;Urea;voltage clamp;Water;water channel;web site;Work;Xenopus oocyte

PROJECT_TITLE: Origins of Renal Physiology

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Hematology;Orphan Drug;Rare Diseases;Sickle Cell Disease

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: The objective of this work is to understand the diversity of clinical presentation in sickle cell disease by studying how heterogeneity propagates from molecules to cells to systemic blood flow. Additionally, we will develop models, tools, and assays that will enable clinical management and therapeutic development.

PI_NAMEs: WOOD, DAVID KEVIN (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: 3-Dimensional;acute chest syndrome;Aneurysm;Behavior;Biological Assay;Biophysical Process;Biophysics;Blood;Blood flow;blood rheology;Blood Vessels;Cells;Chronic;Circulation;Clinic;Clinical;Clinical Management;Communities;Development;Endothelium;Fiber;Functional disorder;Funding;gene therapy;Growth;Hematocrit procedure;Hemoglobin;hemoglobin polymer;Heterogeneity;hydroxyurea;Image;Individual;Injury;insight;Kinetics;Label;Link;Liquid substance;Measurement;mechanical properties;Microscopy;Modeling;Molecular;multi-scale modeling;novel therapeutics;Oxygen;Pathology;Patients;Physiological;polymerization;Polymers;Population;Population Heterogeneity;Property;Resolution;Role;self assembly;shear stress;Sickle Cell Anemia;Sickle Hemoglobin;sickling;spatiotemporal;Stroke;Structure;submicron;System;Technology;Testing;therapeutic development;Therapeutic Intervention;tool;Transfusion;Translating;viscoelasticity;Whole Blood;Work

PROJECT_TITLE: Developing a multiscale understanding of biophysical processes in sickle cell disease

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: PROJECT NARRATIVE:  Viruses have been engineered into invaluable tools for research and vehicles for therapeutics, but none effectively reach neuroimmune cells. The Zika virus offers a host of mechanisms to selectively target and suppress the intrinsic and innate immune responses of microglia, the predominant immune cell. We propose the domestication of Zika into a neuroimmune selective vector and a platform for tailored immunomodulation. The bioactivity can be harnessed into root cause therapies for the treatment of neuroinflammatory and degenerative diseases.

PI_NAMEs: BARTELLE, BENJAMIN B (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Address;Alzheimer's Disease;Animal Model;Anti-Inflammatory Agents;Astrocytes;Autophagocytosis;Biomedical Engineering;Blood - brain barrier anatomy;Brain;Cell Culture System;Cell Culture Techniques;Cell Line;cell type;Cells;clinical development;Clinical Trials;clinically relevant;Degenerative Disorder;Directed Molecular Evolution;Disease;Engineering;Enzyme-Linked Immunosorbent Assay;Evolution;gene therapy;Gene Transduction Agent;Genes;Genome Stability;Harvest;Helper-Inducer T-Lymphocyte;Human;Human Biology;human embryonic stem cell;human induced pluripotent stem cells;Immune;immunoregulation;Immunosuppression;Infection;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Innate Immune Response;Mediating;Medical;Medicine;Mental Depression;Methods;Microglia;Modeling;mutant;Natural regeneration;Nature;Neurodegenerative Disorders;Neuroimmune;neuroinflammation;Neuronal Differentiation;Neurons;neuropsychiatric disorder;NF-kappa B;novel strategies;Parkinson Disease;particle;Pathogenicity;Pathologic;Pathology;Pathway interactions;Pharmaceutical Preparations;pleiotropism;pre-clinical therapy;preclinical development;pressure;programs;Property;Recombinants;Research;Resistance;RNA;RNA Stability;Sampling;Shapes;Signal Pathway;single-cell RNA sequencing;small molecule;Source;STAT1 gene;Structural Genes;suicide gene;synthetic biology;targeted treatment;Technology;Therapeutic;Titrations;tool;transcriptome sequencing;transcriptomics;Transduction Gene;Tropism;Vaccine Therapy;vector;Viral;Viral Genome;Viral Vector;Virus;virus tropism;whole genome;Work;ZIKA;Zika Virus

PROJECT_TITLE: Engineering a human neuroimmune specific viral vector from Zika virus

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE  The gallbladder is the bacterial reservoir for enteric pathogens such as Listeria monocytogenes and Salmonella Typhi, which are responsible for significant morbidity and mortality worldwide. However, very little is known about how enteric pathogens colonize the gallbladder. Experiments in this proposal will define the gallbladder as a replicative niche and identify the bacterial genes required for replication in this organ, which will uncover potential therapeutic targets to reduce colonization and transmission of enteric pathogens.

PI_NAMEs: WOODWARD, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Adult;Attenuated;Bacteria;Bacterial Genes;Bacterial Infections;Biochemical;biological adaptation to stress;Campylobacter;cell growth;Cells;Columnar Epithelium;Critical Pathways;Data;Disease;Engineering;enteric infection;enteric pathogen;Environment;Epithelial Cells;Epithelium;Exhibits;experimental study;extracellular;Flow Cytometry;foodborne pathogen;Fractionation;Gallbladder;Gastrointestinal tract structure;Genes;Growth;Histology;Immune;immune clearance;Immune response;Immunohistochemistry;in vivo;Infection;Infiltration;innate immune pathways;innovation;insight;Interferons;Intestines;Invaded;Investigation;Listeria monocytogenes;Liver;Metabolic;Metabolic Pathway;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mucous body substance;Mus;mutant;Nature;new therapeutic target;nonhuman primate;novel;Nutrient;Nutrient availability;Oral;Organ;Oxidation-Reduction;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Pattern;Persons;Proliferating;Regulation;Reporter;Role;Salmonella;Salmonella typhi;Signal Pathway;Source;Spleen;stressor;Testing;therapeutic target;Time;Tissues;transmission process;transposon sequencing;Virulence

PROJECT_TITLE: The role of redox sensing in Listeria monocytogenes pathogenesis

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Complementary and Integrative Health;Dementia;Genetics;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: PROJECT NARRATIVE A low-carbohydrate ketogenic diet replicates some of the biological features of fasting or dietary restriction, and like these has recently been shown to improve lifespan and age-related memory decline in laboratory mice. Ketogenic diets are also being investigated in the treatment of Alzheimer's disease, although the mechanism by which it might work is unclear. This project will determine the specific mechanisms of ketogenic diet that improve memory both in normal aging and in Alzheimer's disease models, in order to create new therapies that target both the features of Alzheimer's disease and of the aging brain in which it occurs.

PI_NAMEs: NEWMAN, JOHN C (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Acetoacetates;Acetylation;Acute;age related;age related decline;Age-associated memory impairment;Aging;aging brain;aging mechanism;aging related disease;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid beta-Protein;beta-Hydroxybutyrate;Binding;Biological;Biological Assay;Biological Markers;Biology;Brain;brain dysfunction;brain health;C57BL/6 Mouse;Carbohydrates;Cell Physiology;Cells;Chemicals;Clinical Trials;Cognitive;combinatorial;Complex;Data;design;Diet;dietary;dietary restriction;Disease;effective intervention;effective therapy;Electrophysiology (science);Elements;enantiomer;Energy Metabolism;Enzyme Inhibition;Enzymes;Epigenetic Process;Epilepsy;epileptiform;Esters;Exercise;Fasting;feeding;functional decline;Functional disorder;gamma-Aminobutyric Acid;Gene Expression;Genetic;Geroscience;Glucose;Glutamates;Hippocampus;Histone Deacetylase Inhibitor;Histones;human old age (65+);improved;in vitro Assay;in vivo;Individual;Inflammasome;Inflammation;inhibitor;innovation;Intervention;Intraperitoneal Injections;Investigation;ketogenesis;ketogenic diet;Ketone Bodies;Ketones;Knock-out;Laboratories;Laboratory mice;life span;Link;Lipids;Macronutrients Nutrition;Maps;Mass Spectrum Analysis;Memory;Memory impairment;Memory Loss;Metabolic;Metabolism;Molecular;Molecular Target;mouse model;Mus;Neurons;neuroprotection;new therapeutic target;normal aging;nutrition;Oral;oxidation;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Phenotype;Post-Translational Protein Processing;prevent;Prevention;Production;protein function;Proteins;Proteome;Proteomics;receptor;resilience in aging;response;Science;senescence;Signal Transduction;Site;small molecule;System;targeted agent;targeted treatment;tau Proteins;Testing;Time;Tissues;tool;translational study;Visuospatial;Wild Type Mouse;Work

PROJECT_TITLE: Mechanisms of the signaling metabolite β-hydroxybutyrate in Alzheimer's disease and the aging brain


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: Project Narrative NICHD established the Global Network for Women’s and Children’s Health Research to improve health outcomes for women and children in low- and lower middle-income countries (LMICs) by researching sustainable, cost-effective health interventions and strengthening research infrastructure and public health intervention capabilities in LMICs. A Data Coordinating Center (DCC) provides essential expertise for a large multi-country research network by ensuring rigorous, harmonized standards for study design, development, data collection, and data analyses and high-quality implementation across a range of diverse settings. The DCC also coordinates communications, supports the regulatory approval process, procures study equipment and supplies and provides logistical support across diverse research sites, both inside and outside the Global Network.

PI_NAMEs: MCCLURE, ELIZABETH M (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Affect;Biometry;Budgets;Child;Child Health;Child Mortality;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Common Data Element;Communication;Communities;Community Health;computer program;cost effective;Country;Data;Data Analyses;Data Collection;Data Coordinating Center;data management;Data Management Resources;data quality;data sharing;design;Developing Countries;Development;Ensure;Epidemiology;Equipment and Supplies;evidence base;experience;flexibility;Funding;global health;Goals;Government;Grant;Health;health economics;Health Policy;Human Resources;improved;improved outcome;Infant;Infant Development;infant morbidity/mortality;Information Systems;International;Intervention;Investigational Drugs;Knowledge;Lactation;low and middle-income countries;Manuals;Maternal and Child Health;Maternal Health;maternal morbidity;Maternal Mortality;meetings;Monitor;multidisciplinary;National Institute of Child Health and Human Development;neonatal health;Neonatal Mortality;Network Infrastructure;Newborn Infant;nutrition;Online Systems;operation;outreach;participant safety;Peer Review;Perinatal;Persons;Phase;Policies;Population Heterogeneity;pregnant;Principal Investigator;Process;Productivity;Protocols documentation;Public Health;public health intervention;Publications;Qualifying;recruit;Research;Research Design;Research Infrastructure;Research Personnel;Research Support;Resources;Role;Services;Site;Statistical Data Interpretation;stillbirth;Structure;Sustainable Development;System;Telecommunications;Training;United States Food and Drug Administration;United States National Institutes of Health;usability;vision development;Woman;women's outcomes

PROJECT_TITLE: Global Network for Women's and Children's Health Research Data Coordinating Center


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Neisseria gonorrhoeae causes the common STI gonorrhea, for which there are dwindling treatment options and no protective vaccine. N. gonorrhoeae has the striking ability to co-opt human metal-binding proteins, normally meant to restrict bacterial growth, as a source of essential metals. This project seeks to understand the structure and function relationships in four outer membrane transporters produced by N. gonorrhoeae during infection of relevant host cells, to determine the metal environment sensed by N. gonorrhoeae during infection of these cells, and to explore whether inhibitory compounds or monoclonal antibodies block these critical metal acquisition functions, which can point to new therapies against this common infectious disease.

PI_NAMEs: CORNELISSEN, CYNTHIA N (contact);CRISS, ALISON K

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Address;Affect;Affinity;antibiotic resistant infections;Antibodies;Antibody Binding Sites;Area;Bacteria;Bacterial Antibiotic Resistance;Bacteriology;Binding;Binding Proteins;Binding Sites;Biochemical;Biological;Biological Process;Blocking Antibodies;Calgranulin A;Cell Culture Techniques;Cell Survival;cell type;Cells;Cervical;chelation;Communicable Diseases;Culture Media;Data;Dedications;Drug-resistant Neisseria Gonorrhoeae;Environment;Epithelial Cells;Epitopes;experience;extracellular;female reproductive tract infection;Funding;Gene Expression;Genetic;Gonorrhea;Growth;Health;Hemoglobin;Homeostasis;Human;immune clearance;In Vitro;in vitro testing;in vivo;Infection;Inflammation;Inflammatory;inhibitor;innovation;insight;Interdisciplinary Study;Invaded;Investigation;Iron;Knowledge;Lactoferrin;Leukocyte L1 Antigen Complex;Ligand Binding;Ligands;Maps;Mass Spectrum Analysis;Mediating;Membrane;Membrane Transport Proteins;Metals;microbial;Monoclonal Antibodies;Mutagenesis;mutant;Natural Immunity;Neisseria gonorrhoeae;neutrophil;novel therapeutics;Nutrient;Nutritional Immunity;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Persons;Physiological;prevent;Process;promoter;protein expression;protein protein interaction;Proteins;psoriasin;receptor;Reporter;Reporting;Repression;response;S100 Proteins;S100A7;Sexually Transmitted Diseases;Siderophores;Signal Transduction;Site;Site-Directed Mutagenesis;small molecule inhibitor;Source;structural biology;Structural Protein;Structure;Structure-Activity Relationship;Superbug;Surface;System;Techniques;Technology;Testing;Therapeutic Intervention;Time;transcriptome;transcriptome sequencing;Transferrin;Transition Elements;uptake;Vaccines;Zinc

PROJECT_TITLE: Neisseria gonorrhoeae metal transporters that subvert nutritional immunity


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Atrial fibrillation (AF) is the most common cardiac arrhythmia, affecting 2-3% of the US population, and existing therapies focus on management of AF, without addressing underlying causes. Inflammation, vascular leak, and consequent tissue edema are widely associated with AF; yet their role in precipitation atrial arrhythmias remains unclear. In this proposal, we will employ a cutting edge experimental toolkit ranging from the single molecule scale to the whole animal to investigate the mechanisms by which inflammation-induced vascular leak elevates AF risk and develop novel antiarrhythmic drugs that target the mechanistic roots of AF.

PI_NAMEs: VEERARAGHAVAN, RENGASAYEE  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: 3-Dimensional;Acute;Address;Adherens Junction;Adhesions;Adhesives;AF2;Affect;Animals;Anti-Arrhythmia Agents;Arrhythmia;Atrial Fibrillation;Atrial Function;Biochemical;Blood Vessels;Calsequestrin;Cardiac;Cardiac Edema;Cardiovascular Diseases;clinically relevant;Connexin 43;Coupling;cytokine;Data;Defect;Dependence;desmoglein;Desmosomes;Dose;Drug Targeting;Edema;efficacy testing;Electron Microscopy;Electrophysiology (science);Endothelial Growth Factors Receptor;experimental study;Gap Junctions;Heart;Heart Atrium;Human;IL2 gene;Image;Impairment;in vivo;in vivo Model;Inflammation;Inflammatory;inhibitor;innovation;Intercalated disc;KDR gene;Knock-out;Knockout Mice;Link;Modeling;Molecular;monolayer;Mus;Muscle Cells;Myocardial;N-Cadherin;nano;nanoscale;Neonatal;novel;novel therapeutics;patch clamp;Pathology;Patients;Peptides;peptidomimetics;Population;Precipitation;preservation;prevent;Risk;Role;Serum;single molecule;Site;Sodium Channel;stem;stroke risk;Structure;Structure-Activity Relationship;superresolution microscopy;Swelling;Techniques;Testing;thrombogenesis;Tissues;tool;Transgenic Mice;vascular contributions;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factors;Wild Type Mouse;Work

PROJECT_TITLE: Targeting Vascular Leak and Intercalated Disk Nanodomains to Prevent Atrial Fibrillation

STUDY_SECTION: ESTA

STUDY_SECTION_NAME: Electrical Signaling, Ion Transport, and Arrhythmias Study Section[ESTA]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: The emergence of resistance to multiple antimicrobial agents by pathogenic bacteria has become a significant global public health threat. The Gram-negative bacterium Acinetobacter baumannii has evolved in the last 40 years from being a low-virulence pathogen of modest significance to become a leading cause of antibiotic- resistant infections worldwide, causing life-threatening infections of multiple tissues. The bacterium is a scourge of intensive care units and is responsible for about a million infections per year globally. Clinical outcomes are poor, with mortality rates as high as 70% reported. Therefore, multi-drug resistant A. baumannii infections present an enormous ongoing challenge and the development of novel approaches to treat these pathogens is an area of acute medical need.

PI_NAMEs: MELANDER, CHRISTIAN COREY (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acinetobacter baumannii;Acute;Address;Adjuvant;Adjuvant Study;alternative treatment;Anabolism;analog;Animals;anti-microbial drug;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;Area;Bacteria;Bacterial Infections;Baltimore;beta-Lactams;Binding Proteins;Biogenesis;Biological Assay;carbapenem resistance;Carbapenems;Clarithromycin;Clinical;clinically relevant;Colistin;colistin resistance;combat;Consensus;Coupled;Data;Death Rate;design;Development;Dose;Drug Interactions;Drug Kinetics;Evaluation;Goals;Gram-Negative Bacteria;Health care facility;In Vitro;in vitro activity;in vivo;Infection;Intensive Care Units;Lead;lead optimization;Life;Lipid A;lipooligosaccharide;Lung;Macrolides;Maryland;Measures;Medical;member;Membrane;Membrane Proteins;Metabolic;Metabolism;Minimum Inhibitory Concentration measurement;Modeling;Molecular Target;mouse model;Multi-Drug Resistance;Multidrug-resistant Acinetobacter;Multiple Bacterial Drug Resistance;novel strategies;novel therapeutics;O Antigens;optimal treatments;Outcome;outcome prediction;pathogen;pathogenic bacteria;Permeability;Pharmaceutical Preparations;Plasma;Plasma Proteins;Predisposition;Production;programs;Proteins;Protocols documentation;Public Health;Reporting;Research;Research Institute;Resistance;resistance frequency;resistance gene;resistance mechanism;Scourge;side effect;small molecule;Structure;Structure-Activity Relationship;Testing;Therapeutic;Tissues;Toxic effect;treatment choice;Universities;Vancomycin;Virulence;Work

PROJECT_TITLE: Repurposing Gram-positive Antibiotics for Gram-Negative Bacteria using Antibiotic Adjuvants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DDR-C(01)]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_DEPT: DENTISTRY

PHR: Rationale Significant knowledge gaps remain regarding a thorough understanding of HIV replication. Many fundamental aspects of this process, including virus particle assembly, remain understudied, and will be investigated in this study using sophisticated, cutting-edge biophysical technologies. The basic science investigations of virus assembly will aid in addressing crucial knowledge gaps as well as help inform efforts toward next-generation HIV therapies.

PI_NAMEs: MANSKY, LOUIS M. (contact);MUELLER, JOACHIM D

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: 3-Dimensional;Acquired Immunodeficiency Syndrome;Actins;Address;Anti-Retroviral Agents;antiretroviral therapy;Appearance;Basic Science;Behavior;Binding;Biogenesis;Biophysics;Capsid;Capsid Proteins;Cell membrane;cell type;Cells;Color;comparative;Complex;Cryoelectron Microscopy;Cytoplasm;Development;Environment;Event;Exclusion;experimental study;flexibility;Fluorescence;fluorescence imaging;Fluorescence Microscopy;gag Gene Products;genomic RNA;HIV;HIV therapy;HIV-1;HIV-2;Human;Image;improved;Infection;innovation;innovative technologies;insight;Integrase;Investigation;Knowledge;Lentivirus;Life Cycle Stages;Measurement;Membrane;meter;Microscopy;Modeling;Morphogenesis;Morphology;Nature;next generation;novel;particle;Pathway interactions;Peptide Hydrolases;prevent;Process;protein distribution;recruit;Research;Resolution;Retroviridae;Retrovirology;Reverse Transcriptase Inhibitors;Ribonucleoproteins;Role;Site;SP1 gene;Stress;Structure;superresolution imaging;targeted treatment;Techniques;Technology;Therapeutic Intervention;Thick;tomography;two-photon;Viral;Virion;Virus Assembly

PROJECT_TITLE: HIV particle morphology and biogenesis

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Immunization;Infectious Diseases;Nanotechnology;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE After an initial infection with many pathogens, the immune system provides protection against re-infection with the same pathogen. However, infection of the human female reproductive tract with Chlamydia trachomatis provides limited protection against reinfection, and reoccurring infections can cause permanent damage and infertility. The goal of this proposal is to 1) determine why the cells of the immune system fail to provide protection against C. trachomatis, and 2) reprogram these faulty cells using new vaccine approaches to provide protection.

PI_NAMEs: STARNBACH, MICHAEL N (contact)

PROJECT_TERMS: Adaptive Immune System;Adjuvant;Affect;Antigens;Artificial nanoparticles;Automobile Driving;Binding;Biological Response Modifiers;Bypass;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Cellular Immunity;Cellular Immunology;Cellular Structures;Chlamydia;Chlamydia trachomatis;Chronic;Cytosol;Cytotoxic T-Lymphocytes;Development;Effectiveness;Encapsulated;Epithelial Cells;Failure;female reproductive tract;Formulation;Goals;Health Care Costs;Human;human female;Immune system;Immunity;Immunize;Impairment;Individual;Infection;Infertility;Mediating;Membrane;Memory;Methods;Molecular;Morbidity - disease rate;Mus;nanoparticle;novel vaccines;Organism;pathogen;Pathology;Persons;Phenotype;prevent;Primary Infection;programs;Proteins;Reagent;reproductive tract;response;Route;secondary infection;Secondary to;Sexually Transmitted Diseases;success;synergism;T cell response;T memory cell;T-Lymphocyte;Testing;Vaccine Design;vaccine development;vaccine formulation;vaccine strategy;Vaccines;Vaccinia virus;Work

PROJECT_TITLE: Cytotoxic T Cell Mediated Immunity to Chlamydia

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Social Determinants of Health;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed research directly addresses a long-acknowledged scientific gap: the absence of rigorous evidence regarding the causal relationship between unintended pregnancy and childbirth and adverse maternal health outcomes in the US. This longitudinal observational study will utilize a prospective design, novel comparison groups, and a new validated prospective pregnancy preferences measure that moves beyond conceptually limited “unintended” or “intended” labels, to rigorously address issues of confounding, recall bias, and measurement misclassification that have undermined the validity of prior investigations. Evidence to establish whether adverse maternal health outcomes stem from the intention status of pregnancies – independent of underlying social and contextual factors – can facilitate the development of appropriately focused efforts to reduce maternal morbidity and mortality and promote reproductive autonomy.

PI_NAMEs: ROCCA, CORINNE H. (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Accounting;Address;adverse outcome;Affect;Affective;Attitude;avoid pregnancy;Birth;Characteristics;Child;child bearing;Childbirth;Cognitive;cohort;Cohort Studies;community advisory board;comparison group;Conceptions;contextual factors;Contraceptive Agents;Couples;Data;design;Development;Enrollment;Ethnic Origin;experience;follow-up;Funding;Health;health assessment;Health Status;Human Rights;improved;Individual;innovation;insight;instrument;Intention;Intervention;Investigation;Knowledge;Label;Link;longitudinal analysis;Longitudinal, observational study;Maternal and Child Health;Maternal Health;maternal morbidity;Maternal Mortality;maternal outcome;Measurement;Measures;Mental Health;Methods;Morbidity - disease rate;mortality;novel;Outcome;Parents;Participant;Persons;physical conditioning;Positioning Attribute;post pregnancy;preference;Pregnancy;Pregnancy Outcome;Pregnancy Tests;pregnant;Pregnant Women;Prevention;prospective;Prospective Studies;Prospective, cohort study;Psychometrics;racial disparity;Randomized;recruit;reproductive;Research;Research Project Summaries;Residual state;Risk;Sampling;Shapes;Social Desirability;social factors;Socioeconomic Status;stem;Testing;theories;Time;Uncertainty;unintended pregnancy;United States;Woman

PROJECT_TITLE: Pregnancy preferences, reproductive autonomy, and maternal health: A novel prospective study


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Narrative The goal of this project is to develop a new technology platform to measure tens to potentially hundreds of different cancer biomarkers from a single fingerstick of blood collected by patients at home as they begin a new treatment. Our team succeeded in quantifying two distinct nucleic acid targets in such specimens for patients beginning treatment for metastatic castrate resistant prostate cancer. A substantial increase in the number of targets is now needed to validate measurements and to address the diverse genetic landscape of the disease, and could enable the prediction of drug response so that treatment regimens can be rapidly and finely tuned to enhance efficacy and increase survival.

PI_NAMEs: KOHLI, MANISH ;SMITH, ANDREW MICHAEL (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, KRISTIN HEDGEPATH

PROJECT_TERMS: Address;advanced prostate cancer;Agreement;androgen independent prostate cancer;Bar Codes;Base Sequence;Biological Assay;Biological Markers;biomarker discovery;biomarker panel;Biometry;Blood;Blood specimen;Blood Volume;cancer biomarkers;Cancer Patient;Caring;Cessation of life;chemotherapy;Clinic;Clinic Visits;Clinical;Clinical Oncology;clinical translation;Clinical Trials;Code;Collection;Color;companion diagnostics;Complex;cost effective;detection limit;Devices;digital;Disease;docetaxel;Drops;drug response prediction;Evaluation;exosome;Failure;Fingers;Fluorescence;fluorophore;Frequencies;Genetic;Goals;high dimensionality;Home;Hospitals;improved;individual patient;instrument;instrumentation;Label;longitudinal analysis;Longitudinal cohort;Measurement;Measures;Messenger RNA;Microfluidic Microchips;Microfluidics;MicroRNAs;Molecular;Molecular Probes;multiplex assay;Mutation;Neoplasm Metastasis;new technology;Nucleic Acids;Oncologist;Oncology;Optics;Outcome;pandemic disease;participant enrollment;patient response;Patients;performance tests;Pharmaceutical Preparations;photomultiplier;Plasma;Prediction of Response to Therapy;predictive modeling;prevent;prognostic;prognostic model;prospective;Prostate Cancer therapy;Quantitative Reverse Transcriptase PCR;Quantum Dots;rapid test;ratiometric;Reagent;Regimen;Reporting;Reproducibility;response;RNA;Sampling;Scheme;Selection for Treatments;Silicon;single molecule;Source;Specialist;Specimen;Stream;success;survival prediction;System;Technology;technology platform;Testing;Therapeutic;Time;Translational Research;Treatment Protocols;treatment response;Tumor Biology;Validation;Visit;Work

PROJECT_TITLE: Digital Multiplexed Analysis of Circulating Nucleic Acids in Small-Volume Blood Specimens

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: NORTH CHICAGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI

PHR: PROJECT NARRATIVE Prevalence of menthol cigarette (MC) use in the U.S. has reached an all-time high and directly contributes to furthering tobacco-related health disparities. The proposed research will be the first to focus on examining the potential impact of menthol flavoring in cigarettes on biomarkers of systemic inflammation as a subclinical indicator of CVD risk – directly targeting the FDA Center for Tobacco Products (CTP) research priority to understand the cardiovascular and inflammatory health effects of tobacco additives. Research findings are expected to provide the FDA with comprehensive scientific evidence for the development of MC regulations.

PI_NAMEs: JAO, NANCY CHIA LEI (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Accounting;Adult;Affect;Area;Award;Basic Science;biobehavior;Biological Markers;Blood specimen;C-reactive protein;Carbon Monoxide;Cardiovascular Diagnostic Techniques;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;career;Cause of Death;Cessation of life;Cigarette;Cigarette Smoker;cigarette smoking;Clinical;Clinical Trials;combustible cigarette;Confounding Factors (Epidemiology);Cotinine;craving;cytokine;Data;Data Collection;Data Set;design;Development;Disease;Doctor of Philosophy;Early Diagnosis;Ecological momentary assessment;Evaluation;Fibrinogen;Flavoring;follow-up;Functional disorder;Goals;Health;health disparity;Health Hazards;Human;improved;Individual;Inflammation;Inflammatory;Inflammatory Response;Intake;interest;Interleukins;Measures;Menthol;Mentors;Mentorship;Methodology;Methods;Morbidity - disease rate;mortality;non-cigarette tobacco product;Outcome;Participant;Pathway interactions;Pattern;Phase;Policies;Population;Population Assessment of Tobacco and Health;Prevalence;programs;recruit;Regulation;Research;Research Methodology;Research Priority;response;Role;Scientist;Smoker;Smoking;Smoking Behavior;smoking cessation;Statistical Data Interpretation;Stress;Structure;systemic inflammatory response;Time;Tobacco;tobacco exposure;tobacco flavor;tobacco products;tobacco regulatory science;Tobacco use;Training;Translational Research;United States Food and Drug Administration

PROJECT_TITLE: Effect of Menthol to Non-Menthol Cigarette Switching on Subclinical Inflammatory Biomarkers of Cardiovascular Health: Simulating a Menthol Cigarette Ban

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-K(90)S]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Gene Therapy;Genetics;Human Genome

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Relevance to Public Health This project aims to develop a tool that expresses specific proteins in cells in response to the presence of specific RNAs. A molecular tool like this will give us unprecedented specificity, if we want to specifically detect cancer cells and destroy them. The impact will be felt not only in cancer therapies but also other biomedical fields that require the observation/manipulation of specific cells.

PI_NAMEs: GAO, XIAOJING J (contact)

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: Ablation;Adenosine;Affect;Basic Science;Binding;Biological Assay;Biomedical Research;cancer biomarkers;cancer cell;Cancer cell line;cancer classification;Cancer Detection;Cancer Model;cancer therapy;cell type;Cells;clinically relevant;Collection;conventional therapy;delivery vehicle;design;design,build,test;Detection;differential expression;DNA;Double-Stranded RNA;dsRNA adenosine deaminase;Engineering;Enzymes;Exhibits;Future;Genes;Genetic Transcription;Genetic Vectors;Goals;Guanine;Health Benefit;Human;Immune;Immune system;Immunology;improved;In Vitro;in vivo;Inosine;Intervention;Libraries;Logic;Malignant Neoplasms;Mammalian Cell;Medicine;Messenger RNA;Metaphor;Methods;Modification;Molecular;mouse model;Mus;Mutation;Names;Nature;Neurosciences;Nucleic Acids;Oncolytic;oncolytic virotherapy;Oncolytic viruses;operation;Organism;Organoids;Outcome;Output;overexpression;Pathway interactions;Patients;Performance;pharmacologic;posttranscriptional;Printing;Process;Protein Secretion;Proteins;Public Health;Reporter;Reporting;response;RNA;RNA Viruses;RNA-Protein Interaction;senescent cell;sensor;signal processing;Signal Transduction;single-cell RNA sequencing;Specificity;Testing;Therapeutic;tool;Transcript;transcriptome;transcriptomics;Translations;Variant;vector;vector vaccine;Vesicular stomatitis Indiana virus;Viral;Viral Proteins;Viral Vector;Virus Diseases;Virus Replication

PROJECT_TITLE: Cancer Classifiers Based on RNA Sensors in Living Cells


ADMINISTERING_IC: MD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Black women are 2 to 3 times more likely to have pregnancy-related complications leading to maternal death compared to white women nationwide. In response, the State of California passed two bills requiring that all clinicians receive continuing education courses that address implicit bias and mistreatment in effort to improve the quality of care provided to Black women during pregnancy and delivery. This research will be among the first to refine and pilot test a racial equity training intervention for prenatal care clinicians in effort to improve their implicit racial attitudes and beliefs, increase their awareness of causes of racism and health disparities, and enhance their motivation and self-efficacy to use tools and strategies, thereby shifting the healthcare culture and environment.

PI_NAMEs: CHAMBERS, BRITTANY D. (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Accountability;Address;adverse maternal outcomes;adverse pregnancy outcome;Attention;Attitude;Awareness;Behavior;Belief;Biometry;Black race;black women;California;care delivery;career;Caring;Clinical;Clinical Research;cluster randomized design;Communities;Continuing Education;Data;diabetes risk;Discrimination;disparities in women;disparity reduction;Doctor of Philosophy;Ecology;Educational Intervention;efficacy evaluation;Electronic Health Record;Environment;Epidemiology;Evaluation;Evidence based intervention;experience;Face;Faculty;Feedback;Fellowship;Funding;Future;General Hospitals;Goals;Health;Health behavior;health care delivery;health care settings;health disparities in women;health disparity;Health education;Healthcare;High Risk Woman;human centered design;Hypertension;Implementation readiness;implementation science;implicit bias;improved;Individual;infant outcome;Infrastructure;Institution;Intervention;Justice;Lead;Leadership;maltreatment;maternal morbidity;Maternal Mortality;maternal outcome;Measures;Medical;Mentored Clinical Scientist Development Program;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Modeling;Motivation;obesity in pregnancy;obstetric care;online intervention;Outcome;Patient-Focused Outcomes;peer;Perinatal Care;Personal Satisfaction;Persons;pilot test;Positioning Attribute;post intervention;Pregnancy;Pregnancy Complications;prenatal;Prenatal care;Quality of Care;Quasi-experiment;Race;racial bias;racial discrimination;racial disparity;Racial Equity;racism;recruit;reproductive;Reproductive Health;Research;Research Activity;Research Design;Research Personnel;Research Support;Resources;response;Risk;risk mitigation;San Francisco;Self Efficacy;sexual and reproductive health;shared decision making;skills;social;Strategic Planning;structural determinants;success;System;Testing;therapy development;Time;tool;Training;Training Activity;United States;United States National Institutes of Health;Universities;White Women;Woman;women of color;Women's Health

PROJECT_TITLE: Community Racial Equity Training And Evaluation of Current and Future Health Care Clinicians (CREATE) Study


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Infectious Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Reactivation of a persistent infection caused by the protozoan parasite Toxoplasma gondii can result in fatal toxoplasmosis in immune-compromised patients and recurrent ocular disease in otherwise healthy people. Persistent Toxoplasma infection has defied elimination with current treatments. This project will identify new parasite components that are critical for long term persistence of the parasite and thus uncover novel targets for preventing systemic and ocular toxoplasmosis in at-risk individuals.

PI_NAMEs: CARRUTHERS, VERNON BRUCE (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affinity;Amino Acids;Autophagocytosis;Autophagosome;Biogenesis;Biological Models;Cells;Cellular biology;Chronic;chronic infection;Complex;Cyst;Cytoplasm;defined contribution;Development;Disease;Early identification;Eating;Eukaryota;Event;Evolution;experience;Eye diseases;Genes;Goals;Health;Heart Diseases;HIV/AIDS;Homeostasis;Immune;immunodeficiency;In Vitro;in vivo;Individual;Infection;innovation;insight;Literature;Measures;Mediating;Membrane;Mitochondria;Molecular;Molecular Genetics;Mus;mutant;nanobodies;Nervous System Disorder;novel;Ocular Toxoplasmosis;organ transplant recipient;Parasites;pathogen;Pathway interactions;Patients;Persons;Play;postmitotic;prevent;Property;Publishing;Reactive Oxygen Species;recruit;Recurrence;Respiratory Disease;Risk;Role;Sampling;Shapes;spatiotemporal;Structure;Testing;Tissues;Toxoplasma;Toxoplasma gondii;toxoplasmic encephalitis;Toxoplasmosis;virtual;Vision;Work

PROJECT_TITLE: Parasite autophagy as a key survival mechanism for the AIDS-associated pathogen Toxoplasma gondii


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Chromatin remodeling complexes are dysregulated in more than 20% of human malignancies, including adult and pediatric cancers. In this study, we will leverage the low somatic mutation frequencies in rhabdoid tumor and alveolar rhabdomyosarcoma to mechanistically interrogate how chromatin remodeling drives both therapeutic sensitivity and resistance. We will use the information to identify novel therapeutic vulnerabilities that increase the penetrance of therapeutic response and restore chemotherapeutic sensitivity.

PI_NAMEs: CHASSE, MAGGIE  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;Adult;Alveolar Rhabdomyosarcoma;Automobile Driving;Biochemical;Biochemistry;candidate identification;career;Cells;Chemoresistance;chemotherapeutic agent;chemotherapy;childhood sarcoma;Childhood Solid Neoplasm;Chimeric Proteins;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;Cleavage Under Targets and Release Using Nuclease;Clinical;Colorectal Cancer;Combination Drug Therapy;Combined Modality Therapy;Complex;crosslink;Data;Disease;DNA Binding Domain;DNA Damage;DNA Minor Groove Binding;Drug Screening;effective therapy;Epigenetic Process;epigenome;epigenomic profiling;epigenomics;Fellowship;FOXO1A gene;Frequencies;Genetic Transcription;Genome;Genomic approach;Goals;High-Throughput Nucleotide Sequencing;histone demethylase;Human;in vivo;in vivo Model;inhibitor;Investigation;Malignant Childhood Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mass Spectrum Analysis;mouse model;Mutation;new therapeutic target;novel;novel therapeutics;Oncogenes;Oncogenic;Pathway interactions;PAX3 gene;Penetrance;Pharmacology;Phase;Play;Plicamycin;Population;Postdoctoral Fellow;programs;Refractory;Relapse;Research;Residual state;Resistance;resistance mechanism;Resistance profile;response;restoration;Rhabdoid Tumor;Rhabdomyosarcoma;Role;single cell genomics;small molecule;SMARCB1 gene;Solid Neoplasm;Somatic Mutation;synergism;Therapeutic;therapeutic target;Therapeutically Targetable;therapy resistant;Training;transcription factor;transcriptomics;Transgenic Model;treatment response;tumor

PROJECT_TITLE: Characterizing Chromatin Remodeling Mechanisms of Chemo-Sensitivity and Resistance in Pediatric Solid Tumors


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE Lyme disease is a tick transmitted infection with upwards of 470,000 people diagnosed each year in the United States. If untreated or misdiagnosed, the agent of Lyme disease, Borrelia burgdorferi, can persist for long periods of time and can be difficult to treat; thus, understanding how initial infection is regulated may yield better therapeutic or preventative strategies. In this application, we will study how a regulatory protein, important for infection in mammals, directly regulates both DNA and RNA to augment the infectious and pathogenic potential of B. burgdorferi.

PI_NAMEs: HYDE, JENNY A.;SKARE, JON T (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Address;Adhesions;Affect;Arbovirus Infections;Arthropod Vectors;arthropod-borne;Attenuated;Bacteria sigma factor KatF protein;Binding;Binding Sites;Biochemical;Borrelia;Borrelia burgdorferi;Borrelia oxidative stress regulator;ChIP-seq;Complement;Complex;Consensus Sequence;crosslinking and immunoprecipitation sequencing;Cysteine;Data;Diagnosis;dimer;DNA;DNA Binding;DNA Sequence;Etiology;Event;Exhibits;experience;experimental study;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;genetic regulatory protein;Genetic Transcription;Goals;Homologous Gene;Infection;Infectious Agent;innovation;insight;interest;Life Cycle Stages;Link;Lyme Disease;Mammals;Mediating;metalloregulatory protein;Metals;Methodology;Molecular Chaperones;Mus;mutant;novel;Nucleic Acid Binding;Oxidation-Reduction;Oxidative Stress;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Phenotype;Post-Transcriptional Regulation;Prevention;Prevention strategy;Production;Promoter Regions;Proteins;Public Health;Publications;Recording of previous events;Regulation;Regulator Genes;Regulatory Pathway;Regulon;Research;RNA;RNA Binding;Role;Scheme;skills;stem;Structure;Testing;Therapeutic;tick transmission;Time;Transcript;Transcriptional Regulation;transcriptome;transcriptome sequencing;Translations;transmission process;Uncertainty;United States;Untranslated RNA;Virulence;virulence gene;Work

PROJECT_TITLE: Regulatory Pathways in Borrelial Pathogenesis


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE Chronic non-healing skin ulcers are a source of considerable suffering worldwide, particularly in rapidly growing aging populations. Why skin becomes fragile and heals poorly as we age remains unclear, although current research indicates that a major reason may reside in defective “stem cells” in skin that normally fuel its renewal and regeneration in order to maintain healthful and youthful function and appearance. Our findings indicate that stem cell pathways involving cell metabolism, DNA regulation, and cell-cell communication may underlie defective wound healing. Our research proposal is designed to explore this hypothesis with the overarching goal of developing new approaches that will pave the way for stem cell-directed combined therapies that will accelerate wound healing and potentially even repair and restore age-damaged skin.

PI_NAMEs: FRANK, MARKUS H.;MURPHY, GEORGE F (contact)

PROGRAM_OFFICER_NAME: KATIYAR, PRAGATI

PROJECT_TERMS: Acceleration;Address;Affect;Age;age effect;age related;age related changes;aged;Aging;Animals;Appearance;Atrophic;authority;Bioinformatics;Biology;biomarker discovery;Cell Communication;Cells;Cellular Metabolic Process;Chronic;chronic ulcer;Clinical;cofactor;combinatorial;Combined Modality Therapy;comorbidity;COVID-19;Cutaneous;Data;decubitus ulcer;Defect;Dermal;design;Detection;Development;DNA;editorial;Elderly;Epidemic;epidermal stem cell;Epigenetic Process;epigenomics;Evaluation;Evolution;Functional disorder;Generations;Genomics;Goals;healing;Health;health care service utilization;Human;Human Resources;in vivo;Individual;Institution;Left;Maintenance;Maps;Membrane Transport Proteins;Metabolic;metabolomics;Methods;middle age;mouse model;multidisciplinary;Natural regeneration;neglect;Normal tissue morphology;novel;novel strategies;Pathology;Pathway interactions;Phenotype;Physiological;pluripotency;Population;Premature aging syndrome;Prevention;Productivity;psychosocial;receptor;Receptor Cell;Records;regeneration potential;regenerative;regenerative cell;Regenerative response;Regulation;repaired;Research;Research Personnel;Research Proposals;Resources;response;restoration;Role;Severities;Skin;skin damage;Skin injury;skin ulcer;Societies;Source;stem cell biology;stem cell fate;stem cell function;Stem cell pluripotency;stem cells;success;synergism;targeted treatment;Technology;Therapeutic;Therapeutically Targetable;Thinness;tissue injury;tissue repair;United States;wound;wound healing;wound treatment;Youth

PROJECT_TITLE: Multicomponent Therapy for Age-related Skin Stem Cell Deficiency


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Mental Health;Mental Illness;Social Determinants of Health;Telehealth;Violence Research

ORG_DEPT: PSYCHIATRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Considering the rates of elder abuse in the Unites States are growing and many victims have depression and are not receiving care, we propose a randomized controlled trial (N=140) of Tele-PROTECT compared to a video-delivered depression education (DepEd) intervention to test the effectiveness of our behavioral therapy (Tele-PROTECT) specifically targeting older adult victims of abuse. The goal of Tele-PROTECT is to reduce symptoms of depression and support empowerment to take steps to ensure safety for older adults living with abuse and depression, to be delivered via video in English and Spanish, in tandem with the participant’s elder abuse services. The proposal will identify potential barriers and supports for implementation, with the ultimate goal of disseminating Tele-PROTECT nationally to address the widespread needs of this vulnerable older adult population.

PI_NAMEs: SIREY, JO ANNE  (contact)

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: abuse victim;Address;Adopted;Adult;Affect;Age;Aging;Agreement;attentional control;Behavior Therapy;Behavioral;Blinded;Caring;Characteristics;Client;Clinical;clinical practice;clinically significant;Collaborations;Communities;community collaboration;community partners;Consent;Consolidated Framework for Implementation Research;Criminal Justice;Data;Death Rate;Depressed mood;depression education;depressive symptoms;design;Educational Intervention;Effectiveness;effectiveness testing;effectiveness trial;Elder Abuse;Elderly;Eligibility Determination;Emotional;empowerment;Ensure;Ethnic Origin;experience;Feeling suicidal;follow up assessment;future implementation;Gender;Goals;hybrid type 1 trial;implementation facilitators;implementation outcomes;inclusion criteria;Injury;Intervention;Language;Legal;Manipulative Therapies;Manuals;Mediating;Mediator;men;Mental Depression;Methods;Modeling;National Institute of Mental Health;New York City;older adult;Outcome;pandemic disease;Participant;Pilot Projects;Population;practice setting;Premature Mortality;Process;Race;Randomized;Randomized, Controlled Trials;recruit;reduce symptoms;Research;Research Assistant;Research Training;Resolution;Rewards;Safety;Sampling;Services;Severities;Social isolation;Spanish/English;Strategic Planning;synergism;Testing;Time;Translations;underserved community;United States;Victimization;video delivery;virtual;virtual delivery;virtual therapy;Vulnerable Populations;Woman;women of color;Work;World Health Organization

PROJECT_TITLE: Intervention to Reduce Depression Among Elder Abuse Victims: Type 1 Hybrid Trial of Tele-PROTECT

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Aging

PI_NAMEs: MURPHY, GEORGE F (contact)

PROJECT_TITLE: Core A Administrative Core


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

PI_NAMEs: HO SUI, SHANNAN J (contact)

PROJECT_TERMS: Achievement;Address;age related;ATAC-seq;Bioinformatics;bioinformatics pipeline;Biological Models;Chromatin;Clinical;Collaborations;Computer software;Data;Data Analyses;data exploration;data integration;Data Management Resources;Data Set;Deposition;design;DNA Methylation;Epigenetic Process;Event;Experimental Designs;Experimental Models;experimental study;Formulation;Functional disorder;Gene Expression;Genes;Genomic Segment;Goals;Infrastructure;insight;interactive visualization;Intuition;Investigation;Link;Maps;member;Metabolic;Methods;Molecular;multidisciplinary;multiple omics;next generation sequencing;novel;Online Systems;Organism;Pathway interactions;programs;Public Health Schools;Quality Control;Receptor Cell;regenerative healing;Research;Research Personnel;Resources;Retrieval;Role;Sampling;Signal Transduction;Skin;skin regeneration;Software Engineering;statistics;stem cells;System;Testing;transcriptome sequencing;transcriptomics;Visual;Visualization;Visualization software;web portal;Work;wound healing

PROJECT_TITLE: Core B Bioinformatics Core


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Lung;Networking and Information Technology R&D (NITRD);Pediatric;Telehealth

ORG_CITY: GAINESVILLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Early adolescents diagnosed with asthma have difficulties consistently performing disease self-management behaviors, placing them at elevated risk for morbidity and impaired quality of life. The goal of this project is to address the critical need for improving health outcomes in early adolescents with poorly controlled asthma by conducting a randomized controlled trial of a novel intervention, delivered via smartphones, that aims to facilitate helpful caregiver support as early adolescents develop and master asthma self-management behaviors. If successful, our smartphone-based intervention has long-term potential in improving health outcomes for a large number of early adolescents diagnosed with asthma.

PI_NAMEs: FEDELE, DAVID A;PRABHAKARAN, SREEKALA SPRABHAKARAN (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: 15 year old;acceptability and feasibility;Address;Adherence;Adolescent;Adrenal Cortex Hormones;Affect;Age;Asthma;Attention;attentional control;Behavior;Behavior Control;Behavioral;Caregiver support;Caregivers;Cellular Phone;Childhood;Chronic Disease;clinically significant;Communication;comparison control;Conflict (Psychology);cost;design;Development;Diagnosis;Disease;Dissemination and Implementation;early adolescence;Ecological momentary assessment;Education;efficacy testing;Ethnic Origin;evidence base;Evidence based intervention;Family;Feedback;follow-up;Frequencies;Funding;Goals;Guidelines;Health;Impaired health;Impairment;implementation strategy;improved;improved outcome;individualized medicine;Inhalation;innovation;interest;Intervention;intervention effect;Maintenance;Mediating;medication compliance;mHealth;mhealth interventions;Modeling;Monitor;Morbidity - disease rate;novel;Outcome;Participant;Patients;pilot trial;post intervention;prevent;primary outcome;Problem Solving;Protocols documentation;Public Health;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Quality of life;Race;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Risk;satisfaction;secondary outcome;Self Efficacy;Self Management;sex;skills training;Spirometry;success;Symptoms;Techniques;technology intervention;Testing;therapy development;Time;tool;treatment effect;Treatment Protocols;trend;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: AIM2ACT: A Mobile Health Tool to Facilitate Asthma Self-Management during Early Adolescence

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]