NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Structural racism drives inequitable health outcomes in chronic kidney disease (CKD) especially for African Americans in rural settings. We propose to implement Community Rx-Chronic Kidney Disease (CRx-CKD), an infrastructural intervention that integrates medical with social care to reduce the public health burden of CKD by mitigating disparities in care for African American patients. To that end, a partnership of local stakeholders with researchers will build community-to-clinic linkages and test the implementation and effectiveness of CommunityRx in attenuating kidney disease progression.

PI_NAMEs: DAVE, GAURAV J (contact);KSHIRSAGAR, ABHIJIT V;LINDAU, STACY TESSLER

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: Academy;access disparities;Address;Adult;Advocate;Affect;African American;African American population;Albuminuria;Algorithms;arm;Attenuated;Behavior;Black Populations;Black race;Blood Glucose;blood lipid;blood pressure control;Body mass index;Body Weight decreased;Cardiovascular Diseases;care coordination;care systems;Caregivers;Caring;Censuses;Chicago;Chronic Kidney Failure;Clinic;Clinical;Communities;community building;community clinic;Consolidated Framework for Implementation Research;cost effectiveness;County;Death Rate;Development;Diabetes Mellitus;disease disparity;Disease Management;Disease Progression;disparities in morbidity;Disparity;disparity reduction;Effectiveness;effectiveness testing;effectiveness/implementation study;eHealth;Electronic Health Record;Eligibility Determination;Ensure;Environmental Exposure;Equity;evidence base;experience;foot;Fortification;Fostering;glomerular filtration;Glucose;Goals;Health;health care disparity;health disparity;Health equity research;health outcome disparity;Health Personnel;High Prevalence;Home;hospitalization rates;Hyperlipidemia;Hypertension;implementation context;implementation science;improved outcome;Individual;Inequity;Infrastructure;integrated care;Intervention;Kidney;Kidney Diseases;Kidney Failure;Medical;model building;Modeling;multidisciplinary;multiple chronic conditions;North Carolina;novel;Obesity;organizational readiness;Outcome;Pathway Analysis;Patients;Persons;point of care;Policies;post intervention;Poverty;premature;Prevention;primary care clinic;primary outcome;Process;Productivity;programs;Public Health;racism;Randomized, Controlled Trials;Renal Replacement Therapy;Research;Research Personnel;Resources;Rural;Rural Community;rural health clinic;rural setting;rurality;Science;secondary outcome;segregation;Services;social;Structural Racism;Structure;Survey Methodology;System;Telephone;Testing;Text Messaging;treatment as usual;trend;Youth

PROJECT_TITLE: CommunityRx – Chronic Kidney Disease (CRx-CKD)” An EMR-integrated community resources referral intervention to address structural racism and kidney health disparities in rural North Carolina


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed project compares the stress, anthropometric, biological, and epigenetic age profiles of Black and African ancestry older adults across age cohorts (young-old and long-lived) in both the Health and Retirement Study (HRS) and the Study of Longevity and Stress in African American Families (SOLSAA). This project will improve measures of aging in Black communities and support a paradigm shift in aging research, combining medical frameworks with Black centered social frameworks to improve our understanding of the aging process.

PI_NAMEs: BROWN, LAUREN  (contact)

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: accelerated epigenetic aging;Adult;African American;African ancestry;Age;age acceleration;age related;age related changes;age-related disease;Aging;aging process;Alzheimer's Disease;American;Bioethics;Bioinformatics;Biological;biological age;Biological Process;Biosocial;Birth;Black American;Black Populations;Black race;Chronic stress;cognitive function;cohort;Communities;Complex;Data;data reduction;Data Set;Development;Disadvantaged;Disease;DNA Methylation;early onset;Ensure;environmental stressor;Epidemiology;Epigenetic age;epigenetic aging;Epigenetic Process;ethnic disparity;ethnic health disparity;ethnic minority population;Ethnic Origin;Ethnic Population;Event;experience;Family;Funding;Genetic;genetic epidemiology;Genetic Variation;genomic data;hallmarks of aging;Health;Health and Retirement Study;Health Disparities Research;health disparity;Heterogeneity;human old age (65+);improved;Individual;insight;Investments;Joints;K-Series Research Career Programs;Life;Life Cycle Stages;Life Expectancy;Link;Literature;Location;Longevity;Longitudinal cohort study;longitudinal dataset;Longitudinal Studies;Measures;Medical;Mentorship;Molecular;Molecular Biology;Morbidity - disease rate;mortality;multi-ethnic;multidisciplinary;Nature;next generation;older adult;Outcome;Pathway interactions;Pattern;Phase;Phenotype;Physical Function;Population;Process;programs;Public Health Schools;Publications;Race;racial disparity;racial health disparity;racial minority population;racial population;Research;Research Design;Research Methodology;Research Personnel;Resources;response;Sampling;Sampling Studies;skills;social;social disparities;social genomics;social stress;Stress;stressor;Time;Training;Universities;Variant;Work

PROJECT_TITLE: Measuring stress and epigenetic aging among Black older adults in community-based longitudinal studies of aging

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Emergency Care;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Screening and Brief Intervention for Substance Misuse;Substance Misuse;Telehealth;Underage Drinking

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE  Adolescent alcohol and other drug (AOD) use is a significant public health problem which contributes to high levels of mortality, morbidity and healthcare costs in young people, and identification and early intervention for these problems is critical to improving outcomes. Screening, Brief Intervention and Referral to Treatment (SBIRT) in pediatric primary care is an evidence-based strategy for addressing these problems, but has not been widely and systematically implemented, for a variety of reasons, including lack of training and staffing resources to support its implementation. This pragmatic, Type 1 Hybrid Comparative Effectiveness Implementation trial will examine whether a centralized, virtually-delivered modality of SBIRT, rapidly accessible by multiple pediatric primary care clinics, can be cost-effectively implemented to improve early identification and treatment for AOD use and comorbid mental health problems among adolescents identified as being at high or severe risk of AOD use disorder during adolescent Well Visits.

PI_NAMEs: STERLING, STACY ANN (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: 17 year old;Academy;Acceleration;Accident and Emergency department;Accidents;addiction;Address;Adolescent;adolescent alcohol and drug use;adolescent mental health;Adolescent Psychiatry;Adult;Affect;aged;alcohol and other drug;Alcohol or Other Drugs use;alcohol risk;alcohol use disorder;Alcohols;American;Anxiety;Appointment;arm;Behavioral;behavioral health;brief intervention;Child Psychiatry;Childhood;Clinic;Clinical Data;comorbidity;comparative effectiveness;computerized;cost;cost effective;cost effectiveness;depressive symptoms;Diagnosis;Drug usage;Drug Use Disorder;Early identification;Early Intervention;Early treatment;Education;effectiveness/implementation trial;Electronic Health Record;Eligibility Determination;Emergency Situation;Employment;evidence base;Family;Frequencies;Funding;Health Care Costs;Health Personnel;health service use;Health system;Hybrids;implementation cost;implementation outcomes;implementation process;improved;improved outcome;informant;Injury;Inpatients;insight;Intervention;Interview;Licensing;Marijuana;Medical;medical specialties;Medicine;Mental Depression;Mental Health;Mental Health Services;Modality;Morbidity - disease rate;mortality;older patient;Outcome;pandemic disease;Patient Self-Report;Patient-Focused Outcomes;Patients;pediatrician;Pediatrics;Persons;Population;Population Heterogeneity;Primary Care;primary care clinic;primary care patient;Process;psychiatric comorbidity;Psychiatry;Public Health;Qualifying;Quality of Care;Randomized;Reporting;Research;Resources;Risk;routine care;Sampling;screening;screening, brief intervention, referral, and treatment;service utilization;Services;Speed;Structure;suicidal;Symptoms;telehealth;Telemedicine;Telephone;Time;Tobacco;Training;treatment arm;Treatment Protocols;United States National Institutes of Health;vaping;virtual;virtual delivery;virtual screening;wellness visit;World Health

PROJECT_TITLE: Virtual SBIRT for Pediatric Primary Care: Increasing Access to Screening, Brief Intervention and Referral to Treatment for Alcohol and Other Drug Use via Telehealth

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Social Determinants of Health;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE We could recently show that an acceptance-based stigma intervention is effective in connecting people with HIV who inject drugs to care, but strategies how to best engage communities of affected people to implement it are unknown. This project uses an existing rich implementation dataset to narrow this gap by informing methods of linking people with HIV who inject drugs to care, specifically by studying implementation strategies for stigma interventions targeting this population. Results will help design subsequent effectiveness- implementation trials engaging community partners to assess how to best make stigma interventions work for people with HIV who inject drugs.

PI_NAMEs: LUNZE, KARSTEN  (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Address;adherence rate;Adoption;Affect;antiretroviral therapy;behavior change;Caring;Choice Behavior;clinical implementation;Communities;community clinic;community engaged intervention;community engagement;community involvement;community partners;coping;Data;Data Set;design;Dimensions;Dose;effectiveness/implementation trial;emotion regulation;empowerment;Epidemic;evidence base;Evidence based intervention;flexibility;Funding;Future;Goals;Harm Reduction;health care delivery;health care quality;health service use;Health Services;Health Services Accessibility;HIV;Hybrids;implementation evaluation;implementation outcomes;implementation research;implementation strategy;Improve Access;improved;injection drug use;interest;Intervention;intervention participants;Interview;Link;Lived experience;meetings;Methods;mindfulness;Modality;Modeling;Monitor;National Institute of Drug Abuse;Outcome;Overdose;Participant;Patient Recruitments;Perception;Persons;Pharmaceutical Preparations;Population;Process;Proctor framework;Protocols documentation;psychologic;Psychologist;Publishing;Quality Control;Quality of Care;Randomized, Controlled Trials;Recommendation;satisfaction;service gap;Site;social stigma;Stigmatization;Structure;substance use;Substance Use Disorder;Supervision;Surveys;Target Populations;Techniques;Testing;therapy design;Training;treatment group;treatment program;Work

PROJECT_TITLE: Community-engaged implementation strategies for acceptance interventions to improve access to care for people with HIV and injection drug use

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLLEGE PARK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE Hemorrhage is accountable for approximately 40% of deaths due to traumatic injuries worldwide as well as the leading cause of mortality in Americans 1-46 years of age. Blood pressure (BP) management is an important component of hemorrhage resuscitation due to its central role in (i) reducing the hemorrhage-induced mortality as well as in (ii) developing novel hemorrhage resuscitation protocols in clinical trials. We will develop a medical device system called the learning-enabled autonomous decision-support (LEAD) system, which can predict future BP in a patient and recommend timings and doses of resuscitation fluid administration in order to maintain the patient’s BP within a clinician-specified goal range, while continuously optimizing its accuracy by learning the patient’s response to administration of fluids.

PI_NAMEs: HAHN, JIN-OH  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Accountability;Age Years;Algorithms;American;Automated Clinical Decision Support;Awareness;Blood Pressure;blood pressure control;Caring;Cessation of life;Clinical;Clinical Data;Clinical Trials;commercialization;Data Set;Decision Support Systems;Development;Dose;Environment;experience;Failure;Fatality rate;follow-up;Future;Goals;Hemorrhage;Hospitals;innovation;Intervention;Learning;learning algorithm;Life;Liquid substance;Medical Device;mortality;novel;Operative Surgical Procedures;patient response;Patients;Physics;physiologic model;Population;Pre-hospital setting;prediction algorithm;prevent;Protocols documentation;Recommendation;Reporting;response;Resuscitation;Risk;Role;Specific qualifier value;success;System;Technology;Testing;Time;Traffic accidents;Translations;Traumatic injury;Vasoconstrictor Agents;Violence;Work

PROJECT_TITLE: Learning-Enabled Autonomous Decision-Support for Blood Pressure Management in Hemorrhage Resuscitation via Population-Informed Statistical Inference

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW HAVEN

ORG_DEPT: CHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Failure of a protein to fold or assemble properly can cause disease or be lethal, therefore, protein interactions are essential to cellular functions as well as pathological processes. While evidence that the cellular environment regulates protein folding and function emerged over a half a century ago, due to challenges associated with studying proteins inside cells we still have limited fundamental information about the effects of cellular interactions on protein properties. Leveraging recent technological advancements that overcome the limitations of past imaging approaches, the results from the proposed research will elucidate protein structural dynamics involved in processes essential to human health and disease.

PI_NAMEs: DAVIS, CAITLIN  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Acclimatization;Address;Algorithms;Behavior;Biochemical;Biological Assay;Biophysics;Cell Physiology;Cells;Development;Disease;Environment;Failure;Health;Human;imaging approach;improved;In Vitro;in vivo;Knowledge;loss of function;Metabolic;Metabolism;Methods;Molecular;molecular dynamics;Nature;Organism;Pathologic;Pathologic Processes;Process;Property;protein aggregation;protein folding;protein function;protein structure;Proteins;proteostasis;Regulation;Research;Resolution;Spatial Distribution;Spectrum Analysis;Stress;Technology;theories;Tissue Differentiation;Tissues;Translating;Visualization;Work

PROJECT_TITLE: Protein Structural Dynamics in Living Cells

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative This project seeks to understand the impact of polymorphic mobile elements on the changes to the 3D structure of the human genome. Previous work has shown that these elements account for more than 50% of chromatin contacts. Accurate mapping of these elements will improve understanding of how fixed and polymorphic mobile elements contribute to population-level variability in regulatory activity, gene expression, and disease risk.

PI_NAMEs: BOYLE, ALAN P (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: 3-Dimensional;Affect;Automobile Driving;Binding;Catalogs;Chromatin;Chromatin Conformation Capture and Sequencing;Chromatin Loop;Code;computational basis;Computer Analysis;Computing Methodologies;cost;CRISPR/Cas technology;Data;Development;disorder risk;DNA Insertion Elements;DNA Transposable Elements;Elements;Etiology;Evolution;Failure;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genome;genome sequencing;genome-wide;Genomics;Goals;Human;Human Biology;human disease;Human Genome;improved;Individual;innovation;Knowledge;Length;Location;Maps;Mediating;Methods;Molecular;Mutagenesis;nanopore;novel;Outcome;Pattern;Phenotype;Play;Population;Process;Retinal blind spot;Role;Sampling;Site;study population;Technology;three dimensional structure;Tissue-Specific Gene Expression;transcription factor;Untranslated RNA;Variant;whole genome;Work

PROJECT_TITLE: Mobile element derived chromatin looping variability in human populations

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Women's Health Research

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Approximately 80% of all breast cancers occur in women older than age 50, but the molecular and cellular processes that can start the growth of breast tumors during aging are not well known. To help answer this question, in this project we will build advanced sequencing and visualization tools that will aid researchers in determining which genes are read to produce which proteins, and where within tissues these events occur. We will then apply these tools to aging healthy breast tissues as well as breast tumors, which will provide important information that can be used to develop new approaches for early breast cancer detection, intervention, and prevention.

PI_NAMEs: ANCZUKOW-CAMARDA, OLGA  (contact);CHUANG, JEFFREY HSU-MIN

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Address;Advanced Development;Age;age related;age related changes;Aging;aging related;Alternative Splicing;Atlases;Biology of Aging;Breast;Breast Cancer Early Detection;Breast Cancer Risk Factor;Breast Epithelial Cells;Cancer Biology;cancer cell;cancer initiation;cancer subtypes;Carcinoma;Cell Communication;Cell Physiology;cell type;Cells;Code;Communities;computerized tools;Computing Methodologies;Data;Data Analyses;data infrastructure;data mining;data resource;Data Set;data sharing;data visualization;Detection;Development;Dissociation;Drug resistance;early detection biomarkers;Epithelium;Event;Evolution;Fibroblasts;Genes;Genomics;Goals;Growth;Human;human old age (65+);Immune;In Vitro;in vivo;Individual;Infrastructure;innovation;insight;Intervention;Knowledge;Length;Ligands;Link;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Gland Parenchyma;Mammary Neoplasms;Maps;Measures;Mediating;Molecular;Morphology;Mus;neoplastic;novel marker;novel strategies;old mice;older women;online resource;Pathology;Pattern;Phase;Phenotype;Population;Prevention;Protein Isoforms;Proteins;receptor;Research;Research Personnel;Resources;response;Risk Factors;RNA;RNA Splicing;Role;Sampling;Screening for cancer;Spatial Distribution;Standardization;success;Systems Biology;Technology;Tissues;tool;Transcript;transcriptome;transcriptome sequencing;transcriptomics;treatment response;tumor;tumor initiation;Tumor Subtype;tumorigenesis;Up-Regulation;Visualization;Visualization software;Woman;Work;young woman

PROJECT_TITLE: Building a spatial transcriptomics infrastructure for isoform profiling in aging pre-neoplastic tissues


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: POTOMAC

ORG_NAME: COG ANALYTICS, LLC

PHR: Project Narrative  African American caregivers of PLWHA have unique needs because they are more likely to experience stressors related to intersecting sources of stigma, discrimination, and caregiving burdens specifically associated with caregiving for PLWHA. The proposed project will enhance and finalize Phase I app development and evaluate its effectiveness in a randomized controlled trial. The project has high public health significance because of its potential to provide an accessible, easy to use mindfulness-based support tool for African American caregivers that could reduce stress, mitigate the harm of intersecting stigmas, and strengthen the caregiver-care recipient relationship.

PI_NAMEs: ALEXANDER, KAREN ;CARSWELL, STEVEN BERNARD (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: African American;African American population;anxiety symptoms;Asian Americans;Attitude;Awareness;burden of illness;burnout;care giving burden;care recipients;care systems;Caregiver Burden;caregiver stress;Caregivers;caregiving;Caring;caucasian American;Collaborations;Communities;community based research;compare effectiveness;Dementia;depressive symptoms;design;Development;Disabled Children;Discrimination;Effectiveness;effectiveness evaluation;Emotional;Evaluation;Exercise;experience;Family;feasibility trial;Feedback;Financial Support;Friends;Health;health disparity;Health Personnel;high risk;HIV/AIDS;improved;Individual;informal care;informal caregiver;informal caregiving;innovation;Intervention;Meditation;member;Mental Depression;Mental Health;mindfulness;mindfulness-based stress reduction;mobile application;online delivery;Outcome;Participant;Patient-Focused Outcomes;Patients;Personal Satisfaction;Persons;Phase;phase 1 study;physical conditioning;pilot test;Play;Population;prevent;primary outcome;promote resilience;prototype;psychoeducation;Public Health;Quality of life;Race;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Reporting;Research;Resources;Role;Sampling;satisfaction;secondary outcome;self-compassion;Services;Small Business Innovation Research Grant;Social Network;social stigma;Source;Stress;stress management;stress reduction;stressor;support tools;Testing;Time;Universities;Yoga

PROJECT_TITLE: Mindfulness Based Stress Reduction App for African American Caregivers


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Nutrition;Obesity;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Narrative The overall goal of this NCI R25 competitive renewal research education program is to offer, evaluate and disseminate a transdisciplinary research in energetics and cancer (TREC) Training Program with virtual educational programs, a 5-day in-person workshop and a year-long mentorship program for early career investigators, with the goal of enhancing the ability of participants to conduct innovative, transdisciplinary research in energetics and cancer research and clinical care. Our TREC Training Program is highly innovative in that currently no training opportunity, course or workshop exists that focuses on energetics and cancer research. The overall impact of this transdisciplinary training program will be defined by the degree to which program participants produce novel and innovative research approaches and discoveries (through funding, presentations and publications), which in turn, may improve the health of the population at risk for cancer as well as cancer survivors.

PI_NAMEs: IRWIN, MELINDA L (contact)

PROGRAM_OFFICER_NAME: ZAHIR, NASTARAN

PROJECT_TERMS: Acceleration;Address;Admission activity;Adult;anti-cancer research;Basic Science;Body mass index;Budgets;Cancer Center;Cancer Control;cancer risk;Cancer Survivor;career;career development;Categories;clinical care;Clinical Sciences;clinical training;Communities;Complex;Country;Death Rate;Development;Disease;Dissemination and Implementation;education research;Educational workshop;Elderly;energy balance;ethnic minority;evidence base;Extramural Activities;Faculty;faculty mentor;Feedback;Funding;Goals;Grant;Hybrids;immune function;Immunotherapy;improved;Incidence;Individual;innovation;Institution;Intervention;Investments;Journals;Knowledge;lifestyle intervention;Low income;Low Prevalence;Malignant Neoplasms;Manuscripts;Mentors;Mentorship;microbiome;Mission;mortality;Newsletter;next generation;novel;Obesity;Obesity associated cancer;Oncology;Participant;Patient Care;Patients;peer coaching;Peer Review;Persons;physical inactivity;Population;population health;Population Sciences;Populations at Risk;Prevalence;Principal Investigator;programs;Public Health Schools;Publications;Publishing;racial minority;recruit;Research;Research Personnel;residence;Resources;Risk Factors;Role;rural setting;Scientist;skills;Training;training opportunity;Training Programs;Unhealthy Diet;virtual;virtual education;webinar;Work;Yale Cancer Center

PROJECT_TITLE: Transdisciplinary Research in Energetics and Cancer (TREC) Training Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE African Americans are less likely to receive quality end-of-life (EoL) care. Addressing disparities in EoL care will need efforts to support a better understanding of African American patients’ EoL cultural values and preferences for EoL communication, and the impact of historical and ongoing care delivery inequities in healthcare settings. Our proposed “Caring for Older African Americans” training program is designed to empower clinicians to improve goal-concordant EoL care delivery by using community-developed storytelling videos to create empathy with experiences of racism in EoL care, guidelines for culturally concordant EoL care delivery, and an implicit bias recognition and management training to mitigate bias in goals of care communication.

PI_NAMEs: ELK, RONIT  (contact);TJIA, JENNIFER

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Address;Adult;Affect;African American;African American population;Alabama;Attitude;Awareness;care delivery;Caring;Clinical Trials;Cluster randomized trial;Communication;Communities;community advisory board;community based participatory research;comparative;Complex;Consensus;cultural values;design;Discrimination;Disparity;disparity gap;disparity reduction;efficacy evaluation;Elderly;Elements;Empathy;empowerment;end of life;end of life care;end-of-life communication;Equity;Ethnic Origin;Ethnography;experience;Failure;Family;Feeling;Focus Groups;geographic difference;Geography;Geriatrics;Goals;Guidelines;health care settings;health inequalities;Healthcare;Healthcare Systems;Hearing;Human;implicit bias;improved;Individual;Inequity;innovation;Institution;Institutional Policy;Institutional Racism;Intervention;Intervention Studies;Interview;Investments;Knowledge;Label;Life Cycle Stages;Lived experience;maltreatment;Measures;Medical Errors;Medical Sociology;member;Methods;neglect;New York;older adult;palliative;Palliative Care;Patient Care;Patient-Focused Outcomes;Patients;Perception;Persons;Policies;preference;primary outcome;Prognosis;programs;prototype;Publishing;Quality of Care;Race;racial disparity;racism;Randomized;Recommendation;Reporting;Research;Resources;Rural;secondary outcome;Shapes;social;Social Change;social culture;social health determinants;Societies;Stress;Structural Racism;Structure;systematic review;Therapeutic;Training;Training Programs;trend;urban dwelling;Voice;Work

PROJECT_TITLE: African American (AA) Communities Speak: Partnering with AAs in the North and South to Train Palliative Care Clinicians to Address Interpersonal and Systemic Racism and Provide Culturally Aligned Care

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Eczema / Atopic Dermatitis;Neurosciences

ORG_CITY: EXTON

ORG_NAME: PRAEVENTIX, LLC

ORG_STATE: PA

PHR: PROJECT NARRATIVE Chronic pruritus, a serious life-affecting disorder impacting an estimated 40 million adults globally, is the most frequent symptom in dermatology and is associated with comorbidities that impact quality of life. While patient relief in acute pruritus can be achieved with various treatments, chronic pruritus has limited, effective treatment options leading to an annual $5.3 Billion healthcare burden in the US (2015). Praeventix proposes to develop PRA-523 as a topical antipruritic agent with a novel mechanism of action.

PI_NAMEs: PIPPIN, DOUGLAS ANTHONY (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: Action Potentials;Acute;Adult;Affect;Afferent Neurons;Alkaline Single-Cell Gel Electrophoresis Assay;Ames Assay;ANK1 gene;antagonist;Antihistamines;Antipruritics;Area;Atopic Dermatitis;Behavior;Binding Proteins;Caring;Cattle;Cells;Chronic;chronic itch;chronic pain;Classification;Clinic;Clinical;comorbidity;comparative;Corneal Opacity;Coupled;Cyclic AMP;Data;Dermal;Dermatology;Dermis;Development;Diagnosis;Disease;Dosage Forms;Dose;Drug Kinetics;Eczema;effective therapy;Ensure;Epidermis;Esthesia;Evaluation;Exhibits;experience;Eye;Family suidae;Female;Formulation;Foundations;Future;genotoxicity;healthcare burden;Human;In Vitro;in vivo;Inflammatory;Ion Channel;irritation;Lead;Life;male;manufacture;Maximum Tolerated Dose;Mediating;Mediator;Medical;Metabolism;Methods;micronucleus;Modeling;Moods;Mus;Neurons;Neutral Red;novel;novel therapeutics;Pathogenesis;Pathway interactions;Patients;Penetration;Peripheral;Permeability;Personal Satisfaction;Pharmaceutical Preparations;Pharmacology Study;Phototoxicity;Plasma;Play;Program Development;programs;Pruritus;Qualifying;Quality of life;Rattus;receptor;Reporting;Research;research clinical testing;Research Contracts;Role;Route;Safety;Serotonergic System;Serotonin;serotonin 7 receptor;Serum;Signal Pathway;Signal Transduction;Skin;skin disorder;skin lesion;Sleep;Symptoms;System;Testing;Therapeutic;Topical application;Toxic effect;Toxicokinetics;Toxicology;Translating;TRPA channel;uptake;Work

PROJECT_TITLE: IND Enabling Studies for the Development of Pruritus Therapeutic PRA-523

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-S(14)B]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Staphylococcus aureus is one of the most common causes of bacterial infection in United States patients. New treatments are critically needed. The proposed work will advance our understanding of the genetic basis for susceptibility to S. aureus bloodstream infection and severity.

PI_NAMEs: FOWLER, VANCE G. (contact);SCOTT, WILLIAM K

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Admixture;African American;Alleles;American;antigen challenge;Antigen-Presenting Cells;Antigenic Variation;Bacteremia;Bacteria;Bacterial Infections;biobank;Biological;Biological Models;Biological Process;Blood Circulation;clinically relevant;cohort;Collection;deep sequencing;density;Endocarditis;Enrollment;European;European ancestry;experience;experimental study;Frequencies;Genetic;Genetic Determinism;genetic risk factor;genetic variant;Genetic Variation;genome wide association study;genome-wide;genome-wide analysis;Genotype;genotyping technology;Goals;Haplotypes;Histocompatibility Antigens Class II;HLA Antigens;Human;human DNA;Immune response;improved;In Vitro;in vivo;in vivo Model;Individual;Infection;innovation;Link;Maps;Medical;methicillin resistant Staphylococcus aureus;Modeling;Multi-Drug Resistance;multi-ethnic;multidisciplinary;Nucleotides;Osteomyelitis;Patients;Predisposition;Prevention;prospective;Prospective cohort;Proteins;Public Health;Research Personnel;Resources;Risk;Sampling;Sepsis;Severities;Soft Tissue Infections;Staphylococcus aureus;Staphylococcus aureus infection;Streptococcus pyogenes;Superantigens;T cell response;T-Lymphocyte;Testing;Transgenic Mice;United States;Variant;Work

PROJECT_TITLE: HLA Fine Mapping to Elucidate S. aureus Susceptibility

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Palliative Care;Racial and Ethnic Minority Health Research;Telehealth

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Caregiving is demanding and stressful, especially when caring for an older adult with multiple illnesses during and after a hospitalization when caregivers are often expected to follow complicated discharge plans and manage complex skilled care at home. The use of a virtual support intervention and customized information about self-care (via the web) and care transitions, may help improve a caregiver’s self-care and coping, decrease their stress and improve the hospital to home experience. The goal of the proposed study is to examine the effect of a virtual face-to-face health coach intervention compared to web-based resource information alone to determine the effectiveness of each intervention.

PI_NAMEs: HIRSCHMAN, KAREN B (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Acute;acute care;Address;African American;arm;Behavior;Black race;care episode;care recipients;Caregiver Burden;caregiver stress;Caregiver support;Caregivers;caregiving;Caring;Chronic;Chronic Disease;Communities;comparative efficacy;comparison intervention;Complex;Consent;Control Groups;coping;cost;cost estimate;COVID-19;Data Reporting;digital health;digital technology;digital tool;Discharge Plannings;Economics;Education;effectiveness evaluation;Emergency department visit;Enrollment;Event;experience;Family member;Goals;group intervention;Health;Health Status;Heart failure;Home;hospital readmission;Hospitalization;Hospitals;Household;Human;improved;improved outcome;Income;informal caregiver;informal caregiving;innovation;interest;Internet;Intervention;intervention cost;Loneliness;Measures;Medicare;Mental Health;Modeling;multiple chronic conditions;neglect;Nurses;older adult;online resource;Outcome;Participant;Patient Self-Report;Patient-Focused Outcomes;Patients;perceived stress;Persons;physical conditioning;Physical Function;Population;pre-pandemic;primary outcome;Problem Solving;Protocols documentation;Race;racial difference;Randomized;Randomized, Controlled Trials;Readiness;readmission rates;Reporting;Research;Resources;response;Risk;Role;Sampling;Self Care;Self Care outcome;Self Efficacy;sex;skills;social;social health determinants;Source;Strategic Planning;Stress;stress management;Subgroup;symposium;Technology;telephone delivery;Testing;Time;Training;Treatment Efficacy;trial design;Uncompensated Care;urgent care;Videoconferencing;virtual;virtual health;virtual healthcare;Visit;web site;Well in self;Woman;Work

PROJECT_TITLE: Improving Care Transitions and Self-care among Informal Caregivers of Hospitalized Older Adults through Digital Tools

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Eye Disease and Disorders of Vision;Immunotherapy;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative: This is a comprehensive career development and research plan centered on the discovery of how the adaptive immune system interfaces with retinal antigens to promote ocular autoimmune disease. Through this proposal the principal investigator will obtain knowledge about experimental models and molecular mechanisms of autoimmune uveitis and skills in the areas of in vivo imaging and analysis of large multiparametric data sets that will allow him to successfully establish a research program in the field of ocular autoimmunity. He will combine these new skills with advanced didactic training, mentorship from world leading experts, and a novel hypothesis to answer highly relevant questions leading to improvements in the care of patients with uveitis.

PI_NAMEs: WALSH, JAMES  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;Adoptive Transfer;Affect;Anatomy;Anterior uveitis;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Aqueous Humor;Area;Arrestins;Autoimmune Diseases;Autoimmune Process;autoimmune uveitis;Autoimmunity;Automobile Driving;autoreactive T cell;axon injury;base;Benign;Blindness;Blood Vessels;brain parenchyma;career;career development;CD4 Positive T Lymphocytes;Cell Adhesion Molecules;cell behavior;cell motility;Cells;Central Nervous System;chemokine;chemokine receptor;Choroid;Circulation;Clinical;clinical training;CNS autoimmunity;CXCR6 gene;cytokine;Data;Data Set;Development Plans;diagnostic development;Diagnostic tests;differential expression;Disease;Doctor of Philosophy;Drainage procedure;Environment;Enzyme-Linked Immunosorbent Assay;Experimental Models;Eye;Eye diseases;Flow Cytometry;Funding;Future;Gene Expression Profile;Goals;Histologic;ICAM1 gene;Image;Immune;Immune response;Immune system;Immunity;Immunohistochemistry;Immunologic Surveillance;Immunology;improved;in vivo imaging;Inflammation;Inflammatory;Institution;intravital microscopy;Knock-in;Knowledge;knowledge base;Learning;Lymphatic;Lymphocyte;Measures;Mediator;Medical;Medical Research;Memory;Meninges;Mentors;Mentorship;Methods;migration;Modeling;Molecular;monocyte;multi-photon;Mus;Nerve Degeneration;Neurosciences;novel;Operative Surgical Procedures;Ophthalmology;Outcome;Ovalbumin;Papillary;Pathogenesis;Pathogenicity;Patient Care;Peripheral;Pharmaceutical Preparations;Play;Population;Principal Investigator;Process;Productivity;programs;Recurrent disease;Research;research and development;Research Personnel;response;Retina;Role;Route;Scientist;Severities;Signal Transduction;skill acquisition;skills;Source;Structure of retinal pigment epithelium;Systemic Therapy;T cell response;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Tissues;trafficking;Training;United States;Universities;Uveitis;vision science;Washington;Work

PROJECT_TITLE: Antigen presentation to the adaptive immune system in the choroid contributes to ocular autoimmune disease


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: Project Narrative The three-dimensional (3D) structure of genome is critically important for gene regulation; and the abnormal 3D genome structures are often associated with diseases such as cancer. This proposal aims to reconstruct and analyze the 3D genome structures of thousands of individual cells, study how 3D genome structures participate in gene regulation, determine whether long noncoding RNAs (lncRNAs) are involved in the formation of genome structures, and build an online knowledge base integrating 3D genome structures with other biological information.

PI_NAMEs: WANG, ZHENG  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;Bioinformatics;Biological;Cells;chromatin remodeling;cohesin;Communities;Complex;Data;Databases;deep learning algorithm;Disease;DNA;Enhancers;Epigenetic Process;Gene Expression Regulation;Genetic;Genome;genome database;genome-wide;Goals;Hi-C;improved;Individual;knowledge base;Malignant Neoplasms;member;Neurons;Other Genetics;Play;Population;Positioning Attribute;Process;Productivity;promoter;protein complex;Proteins;recruit;Regulatory Element;Research;Resolution;Rewards;Role;scaffold;Scientist;Structure;Techniques;three dimensional structure;Untranslated RNA;whole genome;Work

PROJECT_TITLE: Advanced algorithms to infer and analyze 3D genome structures

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: ES

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Climate-Related Exposures and Conditions;Health Effects of Indoor Air Pollution;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY

ORG_STATE: NY

PHR: This proposal will expand upon the existing industrial hygiene program at the City University of New York (CUNY) School of Public Health (SPH) to: 1) revise existing industrial hygiene curriculum to include training in laboratory practices and sensor technologies, 2) fund student research projects in the evaluation and applicability low-cost sensors to quantify workers’ exposure, 3) develop an outreach and training program in industrial hygiene for Spanish speaking occupational health and safety trainers who train construction and other low wage Latinx immigrant workers. We will provide five graduate assistantships per year for students to work with faculty mentors in the research areas of sensor technologies or worker outreach programs. In addition, approximately 35 students enrolled at the CUNY SPH will be training participants per year along with 40 trainers associated with Latinx community-based organization in the New York/New Jersey region who provide training in occupational safety and health in Spanish to low wage workers.

PI_NAMEs: HARARI, HOMERO ;PAVILONIS, BRIAN THOMAS (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: Area;Assistantship;Cities;Collaborations;Collection;college;Communication;Communities;community engagement;community organizations;Community Services;cost;Data;Data Analyses;Detection;Development;Dust;education research;Educational Curriculum;Educational workshop;Emerging Technologies;Enrollment;Environmental Health;Environmental Pollutants;Evaluation;faculty mentor;Foundations;Funding;Goals;hazard;Hazard Assessment;Health Sciences;Hygiene;Immigrant worker;improved;Industrial Health;Industrialization;instrumentation;interest;Laboratories;language training;Latinx;Maps;Master of Science;Measurement;Measures;medical schools;Monitor;New Jersey;new technology;New York;Noise;Occupational;Occupational Exposure;occupational hazard;Occupational Health;occupational health/safety;Organizational Affiliation;outreach program;Participant;Particulate Matter;Performance;programs;Public Health Schools;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;sample collection;Science;sensor;sensor technology;skills;smartphone application;Spanish;student participation;student training;Students;Technology;temporal measurement;Training;training opportunity;Training Programs;Ultraviolet Rays;Universities;Update;volatile organic compound;Wages;wearable device;Work;Workplace

PROJECT_TITLE: New York Training Center for Emerging Technologies in Industrial Hygiene


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: College Station

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

ORG_STATE: TX

PHR: Fragment-based screening promised to make the discovery and development of small molecule therapeutics more efficient and effective. The inherently weak binding of fragments is unfortunately incompatible with current discovery methods. NMR spectroscopy of proteins encapsulated in reverse micelles is being developed to overcome this limitation and thereby permit a fuller realization of the potential of fragment-based drug discovery.

PI_NAMEs: WAND, A. JOSHUA (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Affinity;automated analysis;Automation;Binding;Binding Sites;Biological Assay;Biology;Catalogs;Characteristics;Chemicals;Companions;Complex;cost;cost effective;Crystallography;Data;design;Detection;detection limit;detection method;Development;Dissociation;drug development;drug discovery;drug-like compound;Elements;Eligibility Determination;Encapsulated;Entropy;Equilibrium;Ethane;experimental study;flexibility;Foundations;Goals;high throughput screening;improved;Individual;innovation;insight;Interleukin-1 beta;Lead;Libraries;Ligand Binding;Ligands;Link;Liquid substance;Membrane Proteins;meter;Methods;Micelles;Molecular Structure;nanoscale;Natural Products;NMR Spectroscopy;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Preparation;Process;Propane;Protein NMR Spectroscopy;Proteins;Resources;Sampling;screening;Site;small molecule;small molecule libraries;small molecule therapeutics;Standardization;Surface;surfactant;Technology;Testing;tool;tool development;Uncertainty;Validation;Water;Work

PROJECT_TITLE: Improving Fragment Based Drug Discovery and the Development of Tools for Chemical Biology through Nanoscale Encapsulation and NMR Spectroscopy

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: RIVERSIDE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative (Relevance) Plants and animals are constantly exposed to microbial pathogens, and have evolved sophisticated immune responses to protect themselves from their attacks. By using a plant-fungal interaction system as a model, we discovered that plants communicate with fungal pathogens using small RNAs to induce gene silencing in the counterparty, a mechanism termed Cross-Kingdom RNAi. This project aims to understand how RNAs travel between hosts and pathogens and regulate host immunity and pathogen virulence, which will pioneer advances in understanding host-pathogen communication and in developing effective strategies to control disease.

PI_NAMEs: JIN, HAILING  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Animals;anti-fungal agents;Arabidopsis;Biochemical;Biological Models;Botrytis;Cells;Communication;design;Disease;disorder control;Exposure to;extracellular vesicles;Friends;fungicide;Gene Silencing;Genes;Genetic;Genomics;Health;Host Defense;Human;Immune response;Immunity;infancy;Infection;innovation;insight;Mammals;Messenger RNA;Modeling;Molds;Molecular Biology;Parasites;pathogen;pathogenic fungus;pathogenic microbe;Plants;Production;RNA;RNA Interference;RNA Transport;Small RNA;Sorting;System;Travel;Untranslated RNA;uptake;Vesicle;Virulence

PROJECT_TITLE: Cross-kingdom RNA communications between plant and fungal pathogens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE The prevalence of short sleep duration is 35% among American preschoolers (3 to 5-year-olds) and 53% for Black-American children, a glaring health disparity associated with developmental outcomes in children. This proposed K01 research study will contribute short-term fundamental knowledge about the nature and behavior of parenting practices and behaviors related to bedtime routines to optimize children’s sleep health, by centering the voice of Black families and considering the social determinants of health that filter through Black families that affect child sleep. The application of the knowledge gained in this mixed-methods study, will contribute to the development and testing of a mobile-health, family-centered behavioral sleep intervention for Black families of preschool-aged children to enhance and optimize child sleep health outcomes.

PI_NAMEs: CHUNG, ALICIA  (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: 5 year old;Adolescence;Affect;American;arm;Behavior;Behavioral;behavioral sleep intervention;Biometry;Black American;Black race;career;career development;Child;Child Rearing;Childhood;Clinical Trials Design;Cognitive;Communities;Conduct Clinical Trials;Data;Development;Development Plans;diaries;digital;digital health;digital intervention;digital technology;Disparity;dissemination science;early childhood;evidence base;Evidence based intervention;experience;Family;Family health status;feasibility testing;Focus Groups;Goals;Health;health disparity;health equity;Health Promotion;implementation framework;implementation science;improvement on sleep;Intervention;Knowledge;Life;Link;Lived experience;medical schools;Medicine;Mental Health;Mentored Research Scientist Development Award;Mentors;Methods;mHealth;Nature;New York;Nursery Schools;obesity risk;Outcome;Parent-Child Relations;Parents;Performance;Pilot Projects;population health;Poverty;preference;Prevalence;primary outcome;Procedures;prototype;Questionnaires;randomized, clinical trials;Reduce health disparities;Reporting;Research;research and development;research study;Resistance;Resources;satisfaction;School-Age Population;Scientist;Series;skills;Sleep;Sleep Disorders;sleep health;Social Environment;social health determinants;Structural Racism;Surveys;System;Testing;Training;Universities;Voice;Walking;Work

PROJECT_TITLE: Family-Centered Digital Behavioral Sleep Intervention for Black Families of Preschool-Aged Children


NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Sleep Research;Social Determinants of Health;Violence Research

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

ORG_STATE: RI

PHR: NARRATIVE Healthy sleep is critical for optimal health and development, but there are no public health interventions to support sleep for children in foster care. This proposal will develop and implement a digital public-health-level intervention to support foster caregivers in promoting healthy sleep in the young children in their care. The digital intervention approach has the potential to maximize scalability and reach to support foster children and their caregivers on a national level.

PI_NAMEs: ROJO-WISSAR, DARLYNN MARIE (contact)

PROJECT_TERMS: Active Learning;Address;adolescent mental health;Adult;adverse childhood events;Area;Award;Behavior;behavior change;behavioral health;behavioral outcome;behavioral sleep intervention;Buffers;Cardiovascular Diseases;care systems;career;career development;Caregiver support;Caregivers;Caring;Child;Child Abuse and Neglect;Child Behavior;Child Development;Child Mental Health;Child Nutrition;Child Support;Child Welfare;Childhood;Chronic;Circadian Rhythms;Collaborations;Communities;community partnership;community setting;Conduct Clinical Trials;cost effectiveness;Data;Development;digital;digital intervention;Dissemination and Implementation;Diverse Workforce;early childhood;Early Intervention;early life adversity;early life exposure;Economic Burden;Environment;Evaluation;evidence base;evidence based guidelines;experience;Exposure to;Family;First Generation College Students;flexibility;follow-up;foster care;foster child;foster parent;Fostering;Funding;General Population;Goals;Grant;group intervention;Guidelines;Health;health disparity;health economics;health equity promotion;health service use;Health Status;high risk;Hispanic;Hospitals;implementation outcomes;implementation science;improved;innovation;Institution;Interruption;Intervention;intervention delivery;intervention mapping;Interview;Investments;Licensing;Link;Literature;maltreatment;Measures;medical schools;meetings;Mental Depression;Mental Health;Mentors;Mentorship;Mission;Modification;mortality risk;National Heart, Lung, and Blood Institute;neglect;Nursery Schools;Obesity;Parents;Participant;Patient Self-Report;Physical activity;physical conditioning;Population;Population Intervention;post intervention;Problem behavior;Process;Proctor framework;programs;psychosocial;Public Health;public health intervention;Randomized, Controlled Trials;recruit;Regulation;Reporting;Research;Research Personnel;resilience;Risk;School-Age Population;skills;Sleep;sleep difficulty;Sleep disturbances;sleep health;Stress;Stressful Event;stressor;Structure;Surveys;System;Testing;therapy development;Training;translational scientist;Trauma;trauma exposure;trial design;Underserved Population;Vulnerable Populations;Waiting Lists

PROJECT_TITLE: Development and implementation of a digital sleep intervention for preschoolers in foster care


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: The proposed research is relevant to public health, because our research may lead to development of a highly effective targeted therapy (PEPDG278D) for HER2-positive breast cancer which is resistant to FDA- approved inhibitors of HER2. Overcoming drug resistance in HER2-positive breast cancer remains a major unmet medical need. Therefore, the proposed research is relevant to the part of NCI’s mission that pertains to accelerating scientific discovery to reduce the burden of cancer and suffering of cancer patients.

PI_NAMEs: ZHANG, YUESHENG  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acceleration;acquired drug resistance;Address;advanced disease;Binding;Breast Cancer Cell;Cancer Burden;cancer cell;Cancer Patient;cell growth;Cell Line;Cells;Clinical;Clinical Research;clinically relevant;Codon Nucleotides;Collagen;Combined Modality Therapy;Development;Dipeptidases;Dipeptides;Disease;Disease Outcome;disease prognosis;Disease Progression;Drug Modelings;Drug resistance;Epidermal Growth Factor Receptor;ERBB2 gene;Extracellular Domain;Family member;FDA approved;Gene Amplification;Glycine;Goals;HER2 inhibition;Human;humanized mouse;improved;In Vitro;in vivo;inhibitor;innovation;Malignant Breast Neoplasm;Medical;Metabolism;Methods;Mission;Modeling;Molecular;Monoclonal Antibodies;multidrug resistance inhibition therapy;Mus;mutant;Normal Cell;Normal tissue morphology;novel;Oncogenic;Outcome;overexpression;Patient Selection;Patients;PIK3CG gene;Play;Point Mutation;Pre-Clinical Model;Proline;Proteins;Public Health;receptor expression;Receptor Protein-Tyrosine Kinases;Recombinants;refractory cancer;Research;research clinical testing;Resistance;resistance mechanism;Role;Safety;Signal Transduction;Specificity;targeted treatment;Testing;Therapeutic;therapeutic target;Time;Toxic effect;Trastuzumab;tumor;tumor xenograft;Work;Xaa-Pro dipeptidase

PROJECT_TITLE: Overcoming Drug Resistance in HER2-positive Breast Cancer

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Integrating Stochasticity into Biomolecular Mechanisms: A New  Direction for Biomolecular Modeling Narrative It is increasingly apparent that kinetic selection plays an important role in biology. However, we are just beginning to have the tools necessary to quantify, characterize and understand it. The proposed research aims to develop an experimentally-directed simulation framework for mapping out kinetic landscapes and mechanistic heterogeneity to understand the role of kinetic selection in biomolecular processes.

PI_NAMEs: SWANSON, JESSICA  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Active Biological Transport;Address;antiporter;ATP Hydrolysis;ATP phosphohydrolase;Binding;Biology;biophysical properties;chemical reaction;Collaborations;Data;Event;experimental study;Free Energy;Goals;Heterogeneity;Hydrolysis;innovation;kinetic model;Kinetics;machine learning method;Maps;Methods;Modeling;Molecular Conformation;molecular dynamics;Parameter Estimation;Pathway interactions;Play;Process;quantum;Reaction;Research;Role;Sampling;Secondary to;simulation;single molecule;stoichiometry;System;Testing;tool;Uncertainty;Universities;Utah

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;HIV/AIDS;Infectious Diseases;Social Determinants of Health

PHR: Project Narrative  Extreme weather events (EWEs), such as droughts, floods, and major storms are becoming more common and severe with unprecedented adverse impacts on HIV-related health and other chronic conditions. The proposed mixed methods study brings together a multidisciplinary team of HIV and climate experts for a 5- year study with more than 2 million patients across 44 countries to answer essential research questions, namely “how does exposure to EWEs influence HIV care outcomes over time?”, “which mechanisms drive these associations?”, “which groups are most vulnerable?, and “what promising adaptation and mitigation strategies are being employed at the local level?”. This work will provide critical knowledge to develop and test tailored, comprehensive intervention strategies that address the poor health impacts stemming from EWEs for vulnerable people living with HIV/AIDS.

PI_NAMEs: NASH, DENIS  (contact);WEISER, SHERI DAWN

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Address;Adolescent;advanced disease;Affect;Africa South of the Sahara;African;Age;Agriculture;antiretroviral therapy;Back;care outcomes;Caring;Cessation of life;Cholera;Chronic;Climate;climate change;climate data;climate impact;climate-related health;Clinic;Clinical;Clinical Data;cohort;Collaborations;Communicable Diseases;Communities;Country;Cross-Sectional Studies;Data;Data Analyses;Data Set;Databases;Development;Disease;Disparity;Documentation;Droughts;Enrollment;Epidemiology;Event;Exposure to;extreme weather;Floods;follow-up;Food;food insecurity;Funding;Future;Geographic Locations;Geography;global health;Health;health data;Health Services Accessibility;Heat Waves;HIV;HIV/AIDS;Household;Hurricane;implementation barriers;Incidence;Income;insight;interest;International;Intervention;Investigation;Kenya;Knowledge;Link;Literature;Malaria;Malnutrition;Mathematics;Mental Health;Methods;migration;Monitor;multidisciplinary;novel;Outcome;pandemic disease;Pathway interactions;Patients;Persons;Philippines;Policies;Policy Maker;Population;pregnant;Prevalence;Process;programs;Public Health;public repository;Quasi-experiment;Rain;Research;Research Personnel;resilience;resilience factor;Resolution;Resources;Risk;Rural;rural health clinic;Rwanda;Severities;sex;Shapes;spatiotemporal;stem;Subgroup;Temperature;Testing;therapy adherence;therapy development;Time;tool;Treatment outcome;Viral;Viral Load result;Vulnerable Populations;Work

PROJECT_TITLE: Understand and mitigating the influence of extreme weather events on HIV outcomes: A global investigation

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ORG_CITY: NORFOLK

ORG_NAME: OLD DOMINION UNIVERSITY

PHR: Project Narrative: The Virginia-UCLA-Toronto Biomarker Characterization Center will develop biomarkers for early identification of men with aggressive prostate cancer who will benefit from definitive treatment. We will develop clinically robust assays that incorporate these biomarkers for validation and quantitation of clinical performance.

PI_NAMEs: BOUTROS, PAUL CHRISTOPHER;KISLINGER, THOMAS ;SEMMES, OLIVER JOHN (contact)

PROGRAM_OFFICER_NAME: KOHAAR, INDU

PROJECT_TERMS: Acceleration;Address;algorithm development;Algorithms;assay development;Benchmarking;Biological Assay;Biological Markers;biomarker development;biomarker identification;biomarker panel;biomarker validation;Biopsy;Biopsy Specimen;BRCA2 gene;BRCA2 Mutation;Characteristics;Clinical;clinical care;Clinical Management;cohort;Communication;Data Analyses;Data Science;Data Set;Decision Making;Diagnosis;differential expression;Disease;disorder risk;early detection biomarkers;Early Detection Research Network;Early Diagnosis;Early identification;Ecosystem;Elements;Eligibility Determination;Environment;Equipoise;experience;Fostering;Gene Family;Germ Lines;Goals;Health;Heterogeneity;high risk;improved;Individual;Indolent;inter-institutional;Intervention;Laboratories;laboratory development;Lesion;Life;Liquid substance;Local Therapy;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Mass Spectrum Analysis;men;Modality;Molecular;multimodality;Neoplasm Metastasis;new growth;Newly Diagnosed;novel;Operative Surgical Procedures;Outcome;Pathologist;Patients;Performance;personalized intervention;Phase;Process;programs;Prostate;protein biomarkers;proteogenomics;Protocols documentation;Qualifying;Radiation therapy;Recommendation;Research;Research Personnel;Risk;Risk Assessment;risk stratification;Selection for Treatments;Stratification;Subcategory;Surveillance Program;Talents;tissue biomarkers;Tissues;tool;translational pipeline;tumor;Tumor Tissue;United States;Urine;Validation;Variant;Virginia


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

PI_NAMEs: SEMMES, OLIVER JOHN (contact)

PROJECT_TERMS: Algorithms;assay development;Benchmarking;Biological Assay;Biological Markers;biomarker development;biomarker discovery;biomarker panel;biomarker validation;BRCA2 gene;career;Clinical;Clinical Management;cohort;Communication;Data Analyses;Data Collection;Data Coordinating Center;Data Set;data sharing;design;Development;Disease;disorder risk;Early Detection Research Network;Early Diagnosis;Early identification;Ecosystem;Ensure;Event;experience;Feedback;Fostering;Germ Lines;Goals;Grant;Growth;improved;Indolent;Infrastructure;International;investigator training;Laboratories;laboratory development;Leadership;Lesion;Life;Liquid substance;Logistics;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;meetings;member;men;Mentorship;Molecular;new growth;Newly Diagnosed;Patients;Performance;Phase;Preparation;programs;Prostate;protein biomarkers;proteogenomics;Protocols documentation;Readiness;Reporting;Research;research and development;Research Design;Research Personnel;Resources;response;Risk;risk stratification;Role;Schedule;Site Visit;synergism;Talents;Time;Time Management;Tissues;tool;Training;Tumor Tissue;Urine;Validation;validation studies;Variant;Virginia;Vision

PROJECT_TITLE: Biomarker Discovery & Validation for Early Localized Prostate Cancer Administrative Core


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE DNA modifications such as DNA methylation carry rich information about a cell and can track its functional state in higher eukaryotes. This project aims to develop computational methods to decode cell states from single-cell DNA methylome profiling data using machine learning techniques and multi-omics integration. These methods will help dissect tissue heterogeneity in gene transcriptional regulation and uncover fundamental principles of developmental biology and human disease.

PI_NAMEs: ZHOU, WANDING  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Acceleration;assay development;Biological;Biological Assay;Catalogs;Cell Cycle Stage;Cell Lineage;cell population study;cell type;Cells;chemical stability;Chromatin;Communities;Competence;computational suite;computerized tools;Computing Methodologies;Consensus;Data;data quality;design;Developmental Biology;Disease;disease diagnosis;DNA;DNA Methylation;DNA Modification Process;Engineering;Environment;Epigenetic Process;Eukaryota;Feedback;genetic makeup;Genetic Transcription;genome-wide;Goals;Heterogeneity;High Performance Computing;Human;human disease;laptop;Link;liquid biopsy;Machine Learning;Methods;Methylation;methylome;Mitotic;Modification;multiple omics;Mus;proliferation potential;Quality Control;Recording of previous events;Research;Research Personnel;Resolution;Role;Signal Transduction;Software Tools;Techniques;Tissue Sample;Tissues;tool;trait;Transcriptional Regulation;translational applications;Visualization;Work

PROJECT_TITLE: Decoding Single-cell DNA Methylomes for Epigenetic Cell Identity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Biotechnology;Cancer;Genetic Testing;Genetics;Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

PI_NAMEs: BOUTROS, PAUL CHRISTOPHER (contact)

PROJECT_TERMS: Adoption;Age;aging population;Algorithms;American;Autopsy;Behavior;Benchmarking;Biochemical;Biological Assay;Biological Markers;biomarker development;biomarker panel;biomarker validation;Biopsy;BRCA2 gene;cancer diagnosis;Cancer Etiology;candidate marker;Cessation of life;Classification;Clinical;Clinical Management;cohort;cost;Data;Data Analyses;Data Set;Detection;Diagnosis;diagnostic biomarker;Disease;disorder risk;Distant;DNA Repair;Early Detection Research Network;Early Diagnosis;Early identification;Ecosystem;efficacy testing;Exhibits;Fostering;Gene Expression;gene repair;Genetic;genetic testing;Germ Lines;Germ-Line Mutation;improved;Incidence;Indolent;innovation;Institution;Laboratories;laboratory development;Lesion;Life;lifetime risk;Liquid substance;Local Therapy;Magnetic Resonance Imaging;male health;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Care Costs;men;MicroRNAs;Modernization;Molecular;Molecular Profiling;Monitor;Morbidity - disease rate;mutant;Neoplasm Metastasis;new growth;Newly Diagnosed;Nomograms;novel;Outcome;Pathogenicity;Pathologic;patient subsets;Patients;Performance;Population;predictive marker;premature;Prostate;Prostatic Neoplasms;protein biomarkers;Proteins;proteogenomics;Proteomics;Protocols documentation;Publishing;Quality of life;Radiology Specialty;Research Personnel;Risk;risk stratification;serum PSA;Site;Skin Cancer;standard of care;Stratification;synergism;Talents;Tissues;tool;tumor;Tumor Tissue;United States;urinary;Urine;validation studies;Variant;variant of unknown significance;Virginia

PROJECT_TITLE: Core-Biomarker Development Laboratory


NIH_SPENDING_CATS: Cancer;Machine Learning and Artificial Intelligence;Precision Medicine;Prevention

PROJECT_TERMS: Acceleration;Agreement;Algorithms;Benchmarking;Biological Assay;Biological Markers;biomarker development;biomarker discovery;biomarker panel;biomarker performance;biomarker validation;BRCA2 gene;cancer type;candidate marker;candidate selection;Certification;CLIA certified;Clinical;clinical decision support;clinical decision-making;clinical diagnostics;Clinical Management;clinical translation;cohort;Communities;Data;Data Analyses;Data Discovery;Data Set;design;Development;Diagnostic;diagnostic assay;Disease;disorder risk;Early Detection Research Network;Early Diagnosis;Early identification;Ecosystem;Ensure;Environment;Fostering;Gene Expression;Germ Lines;high dimensionality;Image;Immunoassay;improved;Individual;Indolent;Laboratories;laboratory development;Lesion;Life;Liquid substance;Literature;machine learning method;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Mass Spectrum Analysis;men;Methodology;Methods;Modernization;Molecular;molecular marker;multimodality;new growth;Newly Diagnosed;Patients;Peptides;Performance;Process;programs;Prostate;protein biomarkers;Proteins;proteogenomics;Proteomics;protocol development;Protocols documentation;Quality Control;Reproducibility;Research;Research Personnel;Resources;Risk;risk stratification;RNA;Route;Sensitivity and Specificity;Standardization;statistical and machine learning;statistical learning;Structure;success;Talents;Technical Expertise;Techniques;timeline;Tissues;tool;Translating;Translational Research;Translations;Tumor Tissue;Urine;Validation;Variant;Virginia;Work

PROJECT_TITLE: Core-Biomarker Reference Laboratory


NIH_SPENDING_CATS: Genetics

ORG_CITY: MILWAUKEE

ORG_NAME: MARQUETTE UNIVERSITY

ORG_STATE: WI

PHR: PHS relevance: Telomeres are tightly regulated to maintain chromosomal stability; misregulation of ribonucleic acid (RNA)- protein interactions at telomeres can lead to degenerative disorders and cancer. The goals of this study are to 1) understand how a telomeric structured RNA interacts with a chromatin associated protein and 2) define how these conformational transitions influence gene regulation. The results of this integrative structural and cell biology study will help in the development of therapeutics that target human disease and aberrant cellular differentiation.

PI_NAMEs: REITER, NICHOLAS J (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Acids;Address;Affect;Aging;Allosteric Regulation;Architecture;Binding;Binding Proteins;Binding Sites;Biochemical;Biochemistry;Biology;Biophysics;cancer cell;Cell Differentiation process;Cell Nucleus;Cells;Cellular biology;Cellular Stress;Chromatin;Chromatin Remodeling Factor;Chromosomal Stability;Chromosomes;Complex;conformational conversion;Data;Degenerative Disorder;demethylation;Disease;DNA;DNA Damage;Environment;Enzymes;Epigenetic Process;Excision;G-Quartets;Gene Expression;Gene Expression Regulation;genetic architecture;Genome;Genome Stability;genome-wide;Genomic approach;Goals;Guanosine;Heterochromatin;Higher Order Chromatin Structure;Histones;Homeostasis;Human;human disease;Hybrids;In Vitro;insight;KDM1A gene;Knowledge;Link;Liquid substance;live cell imaging;live cell microscopy;Lysine;Malignant Neoplasms;Mediating;Mediator;Methods;Methylation;Molecular Conformation;Monitor;Neoplasm Metastasis;neuron development;Normal Cell;Nuclear Localization Signal;Nucleic Acids;Nucleosomes;Oncogenic;optogenetics;Pathway interactions;Phase;Phosphorylation;Physical condensation;Play;Process;Property;protein complex;Protein Conformation;protein kinase A kinase;Protein Region;Proteins;recruit;Regulation;response;RNA;RNA Sequences;Role;scaffold;simulation;Site;structural biology;Structure;Telomerase;telomere;Telomere Maintenance;therapeutic development;therapeutic target;Transcript;Transcriptional Regulation;Untranslated RNA;X-Ray Crystallography

PROJECT_TITLE: Structural transitions and RNA-mediated mechanisms of LSD1

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Nanotechnology;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: ORLANCE, INC.

ORG_STATE: WA

PHR: PROJECT NARRATIVE This project will develop a clinic ready, needle-free gene gun (termed the MACH-1™) to deliver a room temperature stable universal influenza DNA vaccine. If successful, these studies will provide a high-performance clinic ready gene gun platform to deliver a universal influenza vaccine that could reduce the burden of influenza diseases worldwide and prevent the next influenza pandemic. These studies would also result in a needle-free, pain-free delivery device to efficiently deliver DNA and RNA vaccines for other infectious diseases and cancer.

PI_NAMEs: FRIZZELL, HANNAH  (contact);FULLER, DEBORAH H.

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: Acceleration;Address;Animals;Antibodies;Antibody Avidity;Antigen Presentation;Antigens;Area;CD8-Positive T-Lymphocytes;Cells;Clinic;clinic ready;Clinical;clinical trial readiness;Communicable Diseases;Conserved Sequence;Cryopreservation;Data;design;Development;Devices;Disease;DNA;DNA delivery;DNA Vaccines;Documentation;Dose;Dryness;Electroporation;Engineering;Epitopes;Exclusion;Feedback;Formulation;Friends;Funding;Future;future pandemic;Gases;gene gun;Generations;Gold;Helium;Housing;Human;human subject;Hydrogen;Immune Evasion;Immune response;Immunity;immunogenicity;improved;Influenza;influenza virus strain;innovation;Investigational Drugs;Lead;Life;lipid nanoparticle;Malignant Neoplasms;Manuals;manufacturing process;Methods;Modification;Molecular Conformation;mouse model;mRNA lipid nano particle vaccine;Mucosal Immune Responses;Mucosal Immunity;mucosal site;Needles;nonhuman primate;Pain Free;Painless;pandemic influenza;particle;Particle Size;Penetration;Performance;Phase;Phase I Clinical Trials;phase I trial;porcine model;portability;Powder dose form;Power Sources;pre-clinical;pre-Investigational New Drug meeting;pressure;prevent;Process;protective efficacy;Reproducibility;RNA;RNA vaccine;Rodent;Rotation;Safety;scale up;Skin;Small Business Innovation Research Grant;Speed;Standardization;Stream;System;T cell response;Technology;Temperature;Testing;Time;transmission process;universal influenza vaccine;vaccine delivery;Vaccine Design;vaccine formulation;vaccine immunogenicity;Vaccines;Variant;Viral;Virus

PROJECT_TITLE: Clinic-Ready MACH-1 Gene Gun for delivery of a universal influenza DNA vaccine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(10)]


NIH_SPENDING_CATS: Cancer;Skin Cancer

ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Grant: Research Specialist (PAR-19-291) Title: High dimensional digital pathology to investigate the tumor microenvironment and its impact on response to therapy This project involves developing a digital pathology platform for highly-multiplexed tissue imaging and data analysis to support NCI-funded grants, including the construction of a melanoma precancer atlas for the Cancer Moonshot Human Tumor Atlas Network. This proposal will also support original research to characterize the cutaneous immune landscape in cancer, autoimmune disease and adverse reactions to drug therapy. Finally, this grant will promote my career development as a research specialist and increase my independence as a scientist in the Laboratory of Systems Pharmacology at Harvard Medical School.

PI_NAMEs: MALIGA, ZOLTAN  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Adverse reactions;Antibodies;Atlases;Autoimmune Diseases;Biological Markers;career development;Cells;cellular imaging;Collaborations;Cutaneous;Data Analyses;Detection;Development;digital pathology;Disease;Doctor of Philosophy;Environment;Funding;Grant;high dimensionality;Human;Image;Immune;Immunofluorescence Immunologic;In Situ Hybridization;Inflammation;Laboratories;Malignant Neoplasms;Manuscripts;medical schools;Melanoma;member;Methods;multiplexed imaging;Mus;Oligonucleotides;Pathology;Periodicity;Pharmacology;Pharmacotherapy;premalignant;Process;programs;Reagent;Reporting;Research;Research Personnel;Resolution;Sampling;Scientist;Senior Scientist;Skin;skin organogenesis;Specialist;Stains;Supervision;System;Technology;Tissue imaging;Tissues;treatment response;tumor;tumor microenvironment;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: High dimensional digital pathology to investigate the tumor micro environment and its impact on response to therapy


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome;Lung;Lung Cancer;Rare Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative An outstanding question in cancer biology is the impact of aneuploidy, or incorrect chromosome number, on tumor progression. This project focuses on two specific chromosome alterations in lung squamous cell carcinoma, with the goals of understanding the dose-dependent effects of their role in cancer development and identifying possible therapeutic targets for squamous cancers.

PI_NAMEs: TAYLOR, ALISON M. (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Adenocarcinoma;Affect;Aneuploidy;arm;Biological Models;Cancer Biology;cancer cell;cancer diagnosis;cancer type;Cell Line;Cell model;Cells;Chemicals;Chromosome 3;chromosome 3q gain;Chromosome abnormality;Chromosome Arm;Chromosome Deletion;Chromosomes;Conventional (Clear Cell) Renal Cell Carcinoma;Data;Development;Disease;DNA copy number;DNA Sequence Alteration;Dose;Epithelial Cells;Esophagus;Event;Exhibits;experimental study;Future;Gene Deletion;Gene Expression;Genes;Genetic Engineering;Genetic Screening;Genetic Transcription;Genome;Genome engineering;Goals;Head and neck structure;HIF1A gene;Human;Human Characteristics;Hypoxia;Individual;insight;Invaded;Laboratories;lipidome;Lipids;Lung;Lung Adenocarcinoma;Malignant Neoplasms;Measures;Methods;migration;Mutate;Mutation;new therapeutic target;novel;Oncogenes;Oncogenic;Organoids;Oxidative Stress;Pathogenesis;Pathway interactions;Patients;Pattern;Phenotype;Phosphatidylinositols;PIK3CA gene;PIK3CG gene;Play;precision medicine;pressure;Production;response;Role;Signal Transduction;Squamous cell carcinoma;Squamous Cell Lung Carcinoma;Squamous Differentiation;stem;System;targeted treatment;therapeutic target;Tissues;tool;transcription factor;tumor;tumor progression;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;VHL gene

PROJECT_TITLE: Elucidating the Consequences of Chromosome 3 Arm Aneuploidies in Squamous Cell Carcinoma

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: GRAND ISLAND

ORG_NAME: CASTNER INCORPORATED

PHR: NARRATIVE We seek to build the nursing discipline-wide capacity and rigor for translational and clinical research methods in environmental health through the Environmental Health Research Institute for Nurse and Clinician Scientists (EHRI-NCS). The goal of this program is to enhance the discipline-wide capacity of nurse scientists and their interdisciplinary clinician scientist collaborators for advanced research methods in environmental health through a flipped classroom, train-the-trainer and mentorship program.

PI_NAMEs: CASTNER, JESSICA  (contact)

PROGRAM_OFFICER_NAME: GARTON, AMANDA E

PROJECT_TERMS: Academy;American;Applications Grants;Applied Skills;Area;asynchronous encounter;Back;Biological Markers;career;Cessation of life;Clinical;clinical practice;Clinical Research;cohort;course development;Dedications;design;Development Plans;disability;Discipline;Discipline of Nursing;Doctor's Degree;Education;education research;Educational process of instructing;Educational workshop;Enrollment;Environmental Exposure;Environmental Health;environmental intervention;Environmental Risk Factor;Environmental Science;Ethics;Faculty Recruitment;flipped classroom;follow-up;Funding;Goals;health data;health determinants;health disparity populations;Health Personnel;Hour;implementation science;Informatics;Intervention;Intervention Studies;Journals;Knowledge;Learning;lectures;Legal;life span;Manuscripts;Measurement;Measures;medical specialties;member;Mentors;Mentorship;Meta-Analysis;Methodology;Methods;Minority Groups;Modeling;Molecular;National Institute of Environmental Health Sciences;Nurses;Nursing Research;Participant;Pathway Analysis;Patient Recruitments;pedagogy;peer;Peer Review;peer support;Philosophy;Physiological;Policies;Population;pragmatic trial;Preparation;programs;Protocols documentation;Qualifying;Randomized, Controlled Trials;recruit;Registered nurse;Reporting;Research;Research Design;Research Institute;Research Methodology;research study;Resource Informatics;Science;Scientist;sensor;Specific qualifier value;Spirometry;Structure;Students;symptom science;Trainers Training;Training;Translational Research;trend;Underrepresented Minority;United States;United States National Institutes of Health;Vulnerable Populations;Work


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative: This five year SEPA project, Simulation Academy at Yale – Youth Entering Science (SAY- YES!), leverages advances in simulation training to promote informal STEM learning for underrepresented high school students in an urban environment. The four year multi-level after-school simulation program engages local public high school students in hands-on experiential learning using multiple technologies including high fidelity mannequin simulators and the opportunities for STEM learning, leadership and mentoring. A longitudinal mentoring program is designed to foster mentoring communities that value STEM engagement, performance and representation through modeling behavior and growth mindsets of our SAY-YES! students.

PI_NAMEs: EVANS, LEIGH V (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Academy;Active Learning;Anatomy;Asian;Behavior;Belief;Black race;career;Career Choice;Characteristics;child poverty;Cities;clinical practice;Clinical Skills;college;Communities;Community Outreach;Complex;Controlled Environment;design;Education;Educational Curriculum;Educational Models;Educational process of instructing;Enrollment;Environment;Ethnic Origin;expectation;experience;Family;Feeling;Fostering;Foundations;Future;Gender;Growth;Health;Healthcare;high school;High School Student;Hispanic;Individual;informal learning;Infrastructure;innovation;interest;Internships;iterative design;Latinx;Leadership;Learning;learning strategy;Link;Manikins;Marketing;mathematical learning;Mathematics;Medical;Medical center;medical schools;mentoring community;Mentors;Mentorship;Methodology;Minority Groups;Mission;Modeling;Motivation;Outcome Assessment;Parents;Participant;Pathway interactions;peer;peer coaching;Performance;Physiology;Productivity;programs;Race;Recommendation;Research;Schools;Science;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;Self Efficacy;simulation;social factors;social learning;Social Network;Socioeconomic Status;STEM career;STEM curriculum;STEM field;student participation;Students;Target Populations;Technology;tenth grade;tool;Training;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;urban setting;Work;Workplace;Youth

PROJECT_TITLE: Simulation Academy at Yale: Youth Entering Science (SAY-YES!)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE Despite advances in MR-guided adaptive radiation therapy for safer treatment of inoperable soft-tissue abdominal cancers, highly conservative organ radiation constraints are used to spare the mobile gastrointestinal organs even at the expense of not treating tumors to prescription doses due to the lack of reliably accurate organ dose accumulation methods. We address this key unmet clinical need by developing and rigorously validating novel Artificial Intelligence DIR (AI-DIR) dose accumulation methods. To test the potential clinical impact, we will use virtual digital twins to quantify actual variations in accumulated dose and the resulting opportunity for adaptive improvements.

PI_NAMEs: TYAGI, NEELAM  (contact);VEERARAGHAVAN, HARINI

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 4D MRI;Abdomen;Accounting;Address;advanced pancreatic cancer;Artificial Intelligence;Cancer Etiology;Cessation of life;Cine Magnetic Resonance Imaging;Clinical;cohort;Communities;comorbidity;Compensation;Complex;Data;Data Set;deep learning;design;Development;digital;digital twin;Disease;Dose;effective therapy;Ensure;Failure;gastrointestinal;Gastrointestinal tract structure;Geometry;Image;image guided;image registration;Imaging technology;improved;innovation;Institution;learning network;Local Therapy;Magnetic Resonance;Magnetic Resonance Imaging;Malignant neoplasm of abdomen;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Medical;Methods;Modeling;Morbidity - disease rate;Motion;Multi-Institutional Clinical Trial;novel;Organ;Palliative Care;pancreatic cancer patients;pancreatic neoplasm;Patients;Periodicity;Peristalsis;Phase;Physiological;Qualifying;Radiation;Radiation Dose Unit;Radiation therapy;Radiation Tolerance;Radiation Toxicity;reconstruction;Research;Research Infrastructure;Resected;respiratory;Risk Reduction;Safety;Shapes;soft tissue;spatiotemporal;Stomach;Survival Rate;Techniques;Testing;Time;Tissues;tool;Toxic effect;Training;Translational Research;tumor;tumor progression;Tumor Volume;Twin Multiple Birth;Unresectable;usability;Validation;Variant;virtual;Visualization

PROJECT_TITLE: Artificial Intelligence powered virtual digital twins to construct and validate AI automated tools for safer MR-guided adaptive RT of abdominal cancers

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative: Glioblastomas are the most common primary malignant brain tumors, they invariably recur even following resection, chemotherapy and radiation, highlighting the need for identifying new targets for therapy. We propose to identify pathways by which microglia, the brain's innate immune cells regulate glioblastoma growth. The proposed studies will help further understand the role of the brain's immune system in glioblastoma and provide proof of concept that microglia-specific pathways can be used as potential effective targets for therapies for this devastating tumor.

PI_NAMEs: EL-KHOURY, JOSEPH EL (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Animals;anti-microbial peptide;Antibodies;Apolipoprotein E;Binding;Bioinformatics;Biology;Brain;brain cell;cell killing;Cells;Cessation of life;chemotherapy;Chemotherapy and/or radiation;Coculture Techniques;Data Set;Diagnosis;epidermal growth factor receptor VIII;Excision;experimental study;Gene Expression;Genes;Genetic Engineering;Genetic Transcription;Glioblastoma;Growth;Human;Immune;Immune system;Immunoglobulins;In Vitro;in vivo;induced pluripotent stem cell;Infiltration;Knockout Mice;Lectin;life span;Malignant neoplasm of brain;Manuals;Measures;Microglia;Modeling;mouse model;Mus;neoplastic cell;neurosurgery;neutralizing antibody;new therapeutic target;Pathway interactions;Patients;Peptides;Phagocytosis;pre-clinical;Process;programs;Recombinants;Recurrence;Research;Role;Sialic Acids;standard of care;targeted treatment;Testing;therapeutic target;therapeutically effective;Time;Transcript;transcriptome;transcriptome sequencing;Transfection;tumor;tumor growth;Tumor Promotion

PROJECT_TITLE: Deciphering the role of Microglia in Glioblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: RELEVANCE The ultimate goal of this proposal is to uncover how pre-mRNA splicing and trafficking through nuclear speckles is controlled by the kinase TAO2, and why TAO2 is required for successful Influenza virus (IAV) replication. This work will have implications not only for viral infections but also for general mechanisms of RNA splicing and nuclear speckle function.

PI_NAMEs: COBB, MELANIE H.;FONTOURA, BEATRIZ MA;LYNCH, KRISTEN W (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Alternative Splicing;Biochemical;Biochemistry;Biological Assay;Cell Nucleus;Cells;Chemicals;Complement;Creativeness;Data;Economic Burden;Event;experience;Gene Expression;Genes;genetic manipulation;Genetic Transcription;Goals;Grant;Health;high resolution imaging;Human;Immune response;Impairment;Infection;influenza infection;Influenza Virus Infected Cells;influenzavirus;insight;Integration Host Factors;knock-down;Label;Link;Maintenance;Mass Spectrum Analysis;Mediating;Messenger RNA;Methods;Microscopy;Morphology;mRNA Precursor;Nuclear;Nuclear Proteins;Nuclear RNA;Phosphorylation;Phosphotransferases;Positioning Attribute;Process;Protein Kinase;Proteins;Regulation;RNA;RNA Processing;RNA Splicing;RNA-Binding Proteins;Role;Shapes;therapeutic target;trafficking;Transcript;transcriptome sequencing;Viral;Viral Genes;Viral Proteins;viral RNA;Virus;Virus Diseases;Virus Replication;Western Blotting;Work

PROJECT_TITLE: Kinase Regulation of Nuclear Speckle Function and Splicing during Influenza Virus Infection

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Environmental signals that influence brain function and development play critical roles in the neural basis of mental disease. Light has long been recognized as a powerful environmental influence on specific brain regions, and we have recently demonstrated that circadian photoperiodic light cycles persistently alter the function of the brain’s serotonin neurons along with depressive and anxiety-like behaviors. Here, we will combine electrophysiological, molecular, and behavioral experiments to examine how circadian photoperiodic light exposure programs serotonin/glutamate neurons of the dorsal raphe nucleus through the modulation of the ion channel TREK-1, and exerts downstream influence on dopaminergic and glutamatergic circuits in the nucleus accumbens relevant to anxiety, depression, and reward-based behaviors.

PI_NAMEs: GRUETER, BRAD ALAN;MCMAHON, DOUGLAS G (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Acute;Affective;Animal Model;anti-depressive agents;Anxiety;anxiety-like behavior;Automobile Driving;base;Behavior;Behavioral;Biological Clocks;Bipolar Disorder;Brain;Brain region;Cell Nucleus;channel blockers;circadian;circadian pacemaker;depressive symptoms;design;Development;Disease;Disproportionately impacts women;Dopamine;Dopamine D2 Receptor;Dorsal;dorsal raphe nucleus;electrical property;Electrophysiology (science);Epidemiology;Exhibits;experience;Experimental Models;experimental study;Female;Glutamates;Goals;hedonic;Human;Intervention;Ion Channel;Learning;Light;Long-Term Effects;Major Depressive Disorder;male;Measures;Mediating;Mental Depression;Mental Health;Midbrain structure;Molecular;monoamine;Mood Disorders;mood regulation;Moods;motivated behavior;Motivation;mRNA Expression;Mus;National Institute of Mental Health;neural;neural circuit;neural network;neurobehavioral disorder;neurobiological mechanism;Neurobiology;neuronal excitability;Neurons;neurophysiology;novel;Nucleus Accumbens;Output;patch clamp;Photoperiod;photoperiodicity;Play;Positive Valence;Potassium Channel;potassium channel protein TREK-1;programs;Psyche structure;Psychological reinforcement;Regulation;Reporting;reuptake;Rewards;Role;Seasonal Affective Disorder;Seasons;Serotonin;sex;Sex Bias;Shapes;Signal Transduction;Site;Synaptic plasticity;System;Transcriptional Regulation;transmission process;Twin Multiple Birth;uptake;Ventral Tegmental Area;Visual System

PROJECT_TITLE: Photoperiodic Programming of Monoamine Brain Circuits

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Membraneless organelles are an essential component of life, and are composed of many types of proteins and nucleic acids. Their function is related to the total and relative concentrations of each component, and regulated by external factors. Using computational molecular physics, we will study how interactions between molecules are predictive of compositions of membraneless organelles, and how external stimuli regulate these interactions.

PI_NAMEs: DIGNON, GREGORY  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Binding;Biological;Biological Process;Biology;Cells;Communities;Computing Methodologies;design;Development;Disease;Dissociation;Environment;Laws;Life;Membrane;Modeling;Molecular Computations;new therapeutic target;Nucleic Acids;Organelles;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Physical condensation;Physics;Process;programs;Proteins;Research;Research Personnel;small molecule;Sodium Chloride;Stimulus;System;Temperature;Theoretical model;Work

PROJECT_TITLE: Physical laws to control and regulate composition of multi-component biomolecular condensates


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Nutrition;Obesity

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Adipose tissue contains a network of immune cells that help maintain normal adipose tissue function, and obesity triggers adipose tissue inflammation that is associated with metabolic dysfunctions, such as type 2 diabetes. The signals and drivers required for the promotion of obesity-associated adipose tissue inflammation are unknown. This proposal seeks to identify the mechanisms involved in the initiation of adipose tissue T cell activation in early and late stages of obesity.

PI_NAMEs: JACKS, RAMIAH DONESHA (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Ablation;Adipocytes;adipokines;Adipose tissue;Anti-Inflammatory Agents;Antigen-Presenting Cells;Award;Bioinformatics;Biological Assay;Biopsy;Blood;career development;CD3 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Cycle Kinetics;Cell Physiology;Cells;Chronic;cytokine;Data;Dendritic Cells;Development;Diabetes Mellitus;diet-induced obesity;dietary;Disease;Ensure;experimental study;Fatty acid glycerol esters;feeding;Frequencies;Germ-Free;Goals;gut microbiota;High Fat Diet;Homeostasis;Human;Immune;immunoregulation;improved;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;inflammatory milieu;Insulin Resistance;insulin sensitivity;insulin signaling;ITGAX gene;Knowledge;Lymphoid;Macrophage;Maintenance;Mediating;Memory;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;MHC Class I Genes;microbiome;Modeling;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrient metabolism;Obese Mice;Obesity;obesity development;Ontology;Organ;Phase;Phenotype;Play;Population;Positioning Attribute;programs;Proliferating;recruit;Regulation;Regulatory T-Lymphocyte;Research;Research Training;response;Role;Signal Transduction;Spleen;T cell response;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Testing;Thinness;Time;Tissue Expansion;Training;Transforming Growth Factor beta;Translational Research;Work

PROJECT_TITLE: Regulation and Maintenance of Adipose Tissue T cells

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]